id sid tid token lemma pos cord-016652-x8t3lf1x 1 1 key key JJ cord-016652-x8t3lf1x 2 1 : : : cord-016652-x8t3lf1x 2 2 cord-016652-x8t3lf1x cord-016652-x8t3lf1x NNP cord-016652-x8t3lf1x 2 3 authors author NNS cord-016652-x8t3lf1x 2 4 : : : cord-016652-x8t3lf1x 2 5 Matthews Matthews NNP cord-016652-x8t3lf1x 2 6 , , , cord-016652-x8t3lf1x 2 7 David David NNP cord-016652-x8t3lf1x 2 8 ; ; : cord-016652-x8t3lf1x 2 9 Emmott Emmott NNP cord-016652-x8t3lf1x 2 10 , , , cord-016652-x8t3lf1x 2 11 Edward Edward NNP cord-016652-x8t3lf1x 2 12 ; ; : cord-016652-x8t3lf1x 2 13 Hiscox Hiscox NNP cord-016652-x8t3lf1x 2 14 , , , cord-016652-x8t3lf1x 2 15 Julian Julian NNP cord-016652-x8t3lf1x 2 16 title title NN cord-016652-x8t3lf1x 2 17 : : : cord-016652-x8t3lf1x 2 18 Viruses virus NNS cord-016652-x8t3lf1x 2 19 and and CC cord-016652-x8t3lf1x 2 20 the the DT cord-016652-x8t3lf1x 2 21 Nucleolus Nucleolus NNP cord-016652-x8t3lf1x 2 22 date date NN cord-016652-x8t3lf1x 2 23 : : : cord-016652-x8t3lf1x 2 24 2011 2011 CD cord-016652-x8t3lf1x 2 25 - - SYM cord-016652-x8t3lf1x 2 26 05 05 CD cord-016652-x8t3lf1x 2 27 - - HYPH cord-016652-x8t3lf1x 2 28 23 23 CD cord-016652-x8t3lf1x 2 29 journal journal NN cord-016652-x8t3lf1x 2 30 : : : cord-016652-x8t3lf1x 3 1 The the DT cord-016652-x8t3lf1x 3 2 Nucleolus Nucleolus NNP cord-016652-x8t3lf1x 3 3 DOI DOI NNP cord-016652-x8t3lf1x 3 4 : : : cord-016652-x8t3lf1x 3 5 10.1007/978 10.1007/978 CD cord-016652-x8t3lf1x 3 6 - - HYPH cord-016652-x8t3lf1x 3 7 1 1 CD cord-016652-x8t3lf1x 3 8 - - HYPH cord-016652-x8t3lf1x 3 9 4614 4614 CD cord-016652-x8t3lf1x 3 10 - - HYPH cord-016652-x8t3lf1x 3 11 0514- 0514- NNS cord-016652-x8t3lf1x 4 1 6_14 6_14 LS cord-016652-x8t3lf1x 5 1 sha sha NNP cord-016652-x8t3lf1x 5 2 : : : cord-016652-x8t3lf1x 6 1 0900622f1395027703f66ec89708c2b22a228509 0900622f1395027703f66ec89708c2b22a228509 CD cord-016652-x8t3lf1x 6 2 doc_id doc_id CD cord-016652-x8t3lf1x 6 3 : : : cord-016652-x8t3lf1x 7 1 16652 16652 CD cord-016652-x8t3lf1x 7 2 cord_uid cord_uid NNS cord-016652-x8t3lf1x 7 3 : : : cord-016652-x8t3lf1x 8 1 x8t3lf1x x8t3lf1x NNP cord-016652-x8t3lf1x 9 1 The the DT cord-016652-x8t3lf1x 9 2 nucleolus nucleolus NN cord-016652-x8t3lf1x 9 3 is be VBZ cord-016652-x8t3lf1x 9 4 a a DT cord-016652-x8t3lf1x 9 5 dynamic dynamic JJ cord-016652-x8t3lf1x 9 6 sub sub JJ cord-016652-x8t3lf1x 9 7 - - JJ cord-016652-x8t3lf1x 9 8 nuclear nuclear JJ cord-016652-x8t3lf1x 9 9 structure structure NN cord-016652-x8t3lf1x 9 10 integral integral JJ cord-016652-x8t3lf1x 9 11 to to IN cord-016652-x8t3lf1x 9 12 the the DT cord-016652-x8t3lf1x 9 13 function function NN cord-016652-x8t3lf1x 9 14 of of IN cord-016652-x8t3lf1x 9 15 a a DT cord-016652-x8t3lf1x 9 16 eukaryotic eukaryotic JJ cord-016652-x8t3lf1x 9 17 cell cell NN cord-016652-x8t3lf1x 9 18 . . . cord-016652-x8t3lf1x 10 1 Some some DT cord-016652-x8t3lf1x 10 2 of of IN cord-016652-x8t3lf1x 10 3 its -PRON- PRP$ cord-016652-x8t3lf1x 10 4 major major JJ cord-016652-x8t3lf1x 10 5 roles role NNS cord-016652-x8t3lf1x 10 6 involve involve VBP cord-016652-x8t3lf1x 10 7 ribosome ribosome NN cord-016652-x8t3lf1x 10 8 subunit subunit NN cord-016652-x8t3lf1x 10 9 biogenesis biogenesis NN cord-016652-x8t3lf1x 10 10 , , , cord-016652-x8t3lf1x 10 11 RNA RNA NNP cord-016652-x8t3lf1x 10 12 processing processing NN cord-016652-x8t3lf1x 10 13 , , , cord-016652-x8t3lf1x 10 14 cell cell NN cord-016652-x8t3lf1x 10 15 cycle cycle NN cord-016652-x8t3lf1x 10 16 control control NN cord-016652-x8t3lf1x 10 17 and and CC cord-016652-x8t3lf1x 10 18 responding respond VBG cord-016652-x8t3lf1x 10 19 to to IN cord-016652-x8t3lf1x 10 20 cellular cellular JJ cord-016652-x8t3lf1x 10 21 stress stress NN cord-016652-x8t3lf1x 10 22 , , , cord-016652-x8t3lf1x 10 23 such such JJ cord-016652-x8t3lf1x 10 24 as as IN cord-016652-x8t3lf1x 10 25 infection infection NN cord-016652-x8t3lf1x 10 26 . . . cord-016652-x8t3lf1x 11 1 Our -PRON- PRP$ cord-016652-x8t3lf1x 11 2 understanding understanding NN cord-016652-x8t3lf1x 11 3 of of IN cord-016652-x8t3lf1x 11 4 the the DT cord-016652-x8t3lf1x 11 5 relationship relationship NN cord-016652-x8t3lf1x 11 6 between between IN cord-016652-x8t3lf1x 11 7 viruses virus NNS cord-016652-x8t3lf1x 11 8 and and CC cord-016652-x8t3lf1x 11 9 the the DT cord-016652-x8t3lf1x 11 10 nucleolus nucleolus NN cord-016652-x8t3lf1x 11 11 has have VBZ cord-016652-x8t3lf1x 11 12 moved move VBN cord-016652-x8t3lf1x 11 13 from from IN cord-016652-x8t3lf1x 11 14 a a DT cord-016652-x8t3lf1x 11 15 phenomenological phenomenological JJ cord-016652-x8t3lf1x 11 16 approach approach NN cord-016652-x8t3lf1x 11 17 describing describe VBG cord-016652-x8t3lf1x 11 18 protein protein NN cord-016652-x8t3lf1x 11 19 localisation localisation NN cord-016652-x8t3lf1x 11 20 to to IN cord-016652-x8t3lf1x 11 21 functional functional JJ cord-016652-x8t3lf1x 11 22 studies study NNS cord-016652-x8t3lf1x 11 23 involving involve VBG cord-016652-x8t3lf1x 11 24 genetic genetic JJ cord-016652-x8t3lf1x 11 25 analysis analysis NN cord-016652-x8t3lf1x 11 26 and and CC cord-016652-x8t3lf1x 11 27 proteomic proteomic JJ cord-016652-x8t3lf1x 11 28 approaches approach NNS cord-016652-x8t3lf1x 11 29 . . . cord-016652-x8t3lf1x 12 1 These these DT cord-016652-x8t3lf1x 12 2 advances advance NNS cord-016652-x8t3lf1x 12 3 have have VBP cord-016652-x8t3lf1x 12 4 provided provide VBN cord-016652-x8t3lf1x 12 5 fundamental fundamental JJ cord-016652-x8t3lf1x 12 6 insights insight NNS cord-016652-x8t3lf1x 12 7 as as IN cord-016652-x8t3lf1x 12 8 to to IN cord-016652-x8t3lf1x 12 9 how how WRB cord-016652-x8t3lf1x 12 10 and and CC cord-016652-x8t3lf1x 12 11 why why WRB cord-016652-x8t3lf1x 12 12 the the DT cord-016652-x8t3lf1x 12 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 12 14 is be VBZ cord-016652-x8t3lf1x 12 15 targeted target VBN cord-016652-x8t3lf1x 12 16 by by IN cord-016652-x8t3lf1x 12 17 many many JJ cord-016652-x8t3lf1x 12 18 different different JJ cord-016652-x8t3lf1x 12 19 viruses virus NNS cord-016652-x8t3lf1x 12 20 both both DT cord-016652-x8t3lf1x 12 21 to to TO cord-016652-x8t3lf1x 12 22 usurp usurp VB cord-016652-x8t3lf1x 12 23 normal normal JJ cord-016652-x8t3lf1x 12 24 functioning functioning NN cord-016652-x8t3lf1x 12 25 and and CC cord-016652-x8t3lf1x 12 26 to to TO cord-016652-x8t3lf1x 12 27 recruit recruit VB cord-016652-x8t3lf1x 12 28 nucleolar nucleolar JJ cord-016652-x8t3lf1x 12 29 proteins protein NNS cord-016652-x8t3lf1x 12 30 to to TO cord-016652-x8t3lf1x 12 31 facilitate facilitate VB cord-016652-x8t3lf1x 12 32 virus virus NN cord-016652-x8t3lf1x 12 33 replication replication NN cord-016652-x8t3lf1x 12 34 . . . cord-016652-x8t3lf1x 13 1 This this DT cord-016652-x8t3lf1x 13 2 knowledge knowledge NN cord-016652-x8t3lf1x 13 3 has have VBZ cord-016652-x8t3lf1x 13 4 been be VBN cord-016652-x8t3lf1x 13 5 exploited exploit VBN cord-016652-x8t3lf1x 13 6 for for IN cord-016652-x8t3lf1x 13 7 therapeutic therapeutic JJ cord-016652-x8t3lf1x 13 8 strategies strategy NNS cord-016652-x8t3lf1x 13 9 involving involve VBG cord-016652-x8t3lf1x 13 10 targeted target VBN cord-016652-x8t3lf1x 13 11 inhibition inhibition NN cord-016652-x8t3lf1x 13 12 of of IN cord-016652-x8t3lf1x 13 13 virus virus NN cord-016652-x8t3lf1x 13 14 replication replication NN cord-016652-x8t3lf1x 13 15 and and CC cord-016652-x8t3lf1x 13 16 live live RB cord-016652-x8t3lf1x 13 17 - - HYPH cord-016652-x8t3lf1x 13 18 attenuated attenuate VBN cord-016652-x8t3lf1x 13 19 recombinant recombinant JJ cord-016652-x8t3lf1x 13 20 vaccines vaccine NNS cord-016652-x8t3lf1x 13 21 . . . cord-016652-x8t3lf1x 14 1 ; ; : cord-016652-x8t3lf1x 14 2 Lee Lee NNP cord-016652-x8t3lf1x 14 3 et et NNP cord-016652-x8t3lf1x 14 4 al al NNP cord-016652-x8t3lf1x 14 5 . . . cord-016652-x8t3lf1x 15 1 ( ( -LRB- cord-016652-x8t3lf1x 15 2 2003 2003 CD cord-016652-x8t3lf1x 15 3 ) ) -RRB- cord-016652-x8t3lf1x 15 4 ; ; : cord-016652-x8t3lf1x 15 5 Lutz Lutz NNP cord-016652-x8t3lf1x 15 6 and and CC cord-016652-x8t3lf1x 15 7 Kedinger Kedinger NNP cord-016652-x8t3lf1x 15 8 ( ( -LRB- cord-016652-x8t3lf1x 15 9 1996 1996 CD cord-016652-x8t3lf1x 15 10 ) ) -RRB- cord-016652-x8t3lf1x 15 11 ; ; : cord-016652-x8t3lf1x 15 12 Tollefson Tollefson NNP cord-016652-x8t3lf1x 15 13 et et NNP cord-016652-x8t3lf1x 15 14 al al NNP cord-016652-x8t3lf1x 15 15 . . . cord-016652-x8t3lf1x 16 1 ( ( -LRB- cord-016652-x8t3lf1x 16 2 2007 2007 CD cord-016652-x8t3lf1x 16 3 ) ) -RRB- cord-016652-x8t3lf1x 16 4 ; ; : cord-016652-x8t3lf1x 16 5 Matthews Matthews NNP cord-016652-x8t3lf1x 16 6 and and CC cord-016652-x8t3lf1x 16 7 Russell Russell NNP cord-016652-x8t3lf1x 16 8 ( ( -LRB- cord-016652-x8t3lf1x 16 9 1998 1998 CD cord-016652-x8t3lf1x 16 10 ) ) -RRB- cord-016652-x8t3lf1x 17 1 Asfaviridae Asfaviridae NNP cord-016652-x8t3lf1x 17 2 Lower Lower NNP cord-016652-x8t3lf1x 17 3 et et FW cord-016652-x8t3lf1x 17 4 al al NNP cord-016652-x8t3lf1x 17 5 . . . cord-016652-x8t3lf1x 18 1 ( ( -LRB- cord-016652-x8t3lf1x 18 2 1995 1995 CD cord-016652-x8t3lf1x 18 3 ) ) -RRB- cord-016652-x8t3lf1x 18 4 Many many JJ cord-016652-x8t3lf1x 18 5 of of IN cord-016652-x8t3lf1x 18 6 these these DT cord-016652-x8t3lf1x 18 7 proteins protein NNS cord-016652-x8t3lf1x 18 8 have have VBP cord-016652-x8t3lf1x 18 9 been be VBN cord-016652-x8t3lf1x 18 10 shown show VBN cord-016652-x8t3lf1x 18 11 to to TO cord-016652-x8t3lf1x 18 12 interact interact VB cord-016652-x8t3lf1x 18 13 with with IN cord-016652-x8t3lf1x 18 14 nucleolar nucleolar JJ cord-016652-x8t3lf1x 18 15 proteins protein NNS cord-016652-x8t3lf1x 19 1 The the DT cord-016652-x8t3lf1x 19 2 reason reason NN cord-016652-x8t3lf1x 19 3 why why WRB cord-016652-x8t3lf1x 19 4 RNA RNA NNP cord-016652-x8t3lf1x 19 5 viruses virus NNS cord-016652-x8t3lf1x 19 6 , , , cord-016652-x8t3lf1x 19 7 and and CC cord-016652-x8t3lf1x 19 8 positive positive JJ cord-016652-x8t3lf1x 19 9 - - HYPH cord-016652-x8t3lf1x 19 10 strand strand NN cord-016652-x8t3lf1x 19 11 RNA RNA NNP cord-016652-x8t3lf1x 19 12 viruses virus NNS cord-016652-x8t3lf1x 19 13 in in IN cord-016652-x8t3lf1x 19 14 particular particular JJ cord-016652-x8t3lf1x 19 15 , , , cord-016652-x8t3lf1x 19 16 interact interact VB cord-016652-x8t3lf1x 19 17 with with IN cord-016652-x8t3lf1x 19 18 the the DT cord-016652-x8t3lf1x 19 19 nucleolus nucleolus NN cord-016652-x8t3lf1x 19 20 when when WRB cord-016652-x8t3lf1x 19 21 the the DT cord-016652-x8t3lf1x 19 22 site site NN cord-016652-x8t3lf1x 19 23 of of IN cord-016652-x8t3lf1x 19 24 genome genome NN cord-016652-x8t3lf1x 19 25 replication replication NN cord-016652-x8t3lf1x 19 26 is be VBZ cord-016652-x8t3lf1x 19 27 in in IN cord-016652-x8t3lf1x 19 28 the the DT cord-016652-x8t3lf1x 19 29 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 19 30 is be VBZ cord-016652-x8t3lf1x 19 31 less less RBR cord-016652-x8t3lf1x 19 32 intuitive intuitive JJ cord-016652-x8t3lf1x 19 33 . . . cord-016652-x8t3lf1x 20 1 In in IN cord-016652-x8t3lf1x 20 2 this this DT cord-016652-x8t3lf1x 20 3 latter latter JJ cord-016652-x8t3lf1x 20 4 case case NN cord-016652-x8t3lf1x 20 5 , , , cord-016652-x8t3lf1x 20 6 viral viral JJ cord-016652-x8t3lf1x 20 7 proteins protein NNS cord-016652-x8t3lf1x 20 8 that that WDT cord-016652-x8t3lf1x 20 9 are be VBP cord-016652-x8t3lf1x 20 10 normally normally RB cord-016652-x8t3lf1x 20 11 required require VBN cord-016652-x8t3lf1x 20 12 in in IN cord-016652-x8t3lf1x 20 13 the the DT cord-016652-x8t3lf1x 20 14 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 20 15 must must MD cord-016652-x8t3lf1x 20 16 transit transit VB cord-016652-x8t3lf1x 20 17 through through IN cord-016652-x8t3lf1x 20 18 the the DT cord-016652-x8t3lf1x 20 19 nuclear nuclear JJ cord-016652-x8t3lf1x 20 20 pore pore NN cord-016652-x8t3lf1x 20 21 complex complex NN cord-016652-x8t3lf1x 20 22 both both DT cord-016652-x8t3lf1x 20 23 to to IN cord-016652-x8t3lf1x 20 24 and and CC cord-016652-x8t3lf1x 20 25 from from IN cord-016652-x8t3lf1x 20 26 the the DT cord-016652-x8t3lf1x 20 27 nucleus nucleus NN cord-016652-x8t3lf1x 20 28 . . . cord-016652-x8t3lf1x 21 1 This this DT cord-016652-x8t3lf1x 21 2 process process NN cord-016652-x8t3lf1x 21 3 is be VBZ cord-016652-x8t3lf1x 21 4 crucial crucial JJ cord-016652-x8t3lf1x 21 5 for for IN cord-016652-x8t3lf1x 21 6 virus virus NN cord-016652-x8t3lf1x 21 7 biology biology NN cord-016652-x8t3lf1x 21 8 because because IN cord-016652-x8t3lf1x 21 9 if if IN cord-016652-x8t3lf1x 21 10 the the DT cord-016652-x8t3lf1x 21 11 viral viral JJ cord-016652-x8t3lf1x 21 12 proteins protein NNS cord-016652-x8t3lf1x 21 13 that that WDT cord-016652-x8t3lf1x 21 14 are be VBP cord-016652-x8t3lf1x 21 15 required require VBN cord-016652-x8t3lf1x 21 16 for for IN cord-016652-x8t3lf1x 21 17 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 21 18 functions function NNS cord-016652-x8t3lf1x 21 19 such such JJ cord-016652-x8t3lf1x 21 20 as as IN cord-016652-x8t3lf1x 21 21 RNA RNA NNP cord-016652-x8t3lf1x 21 22 synthesis synthesis NN cord-016652-x8t3lf1x 21 23 and and CC cord-016652-x8t3lf1x 21 24 encapsidation encapsidation NN cord-016652-x8t3lf1x 21 25 are be VBP cord-016652-x8t3lf1x 21 26 sequestered sequester VBN cord-016652-x8t3lf1x 21 27 in in IN cord-016652-x8t3lf1x 21 28 the the DT cord-016652-x8t3lf1x 21 29 nucleolus nucleolus NN cord-016652-x8t3lf1x 21 30 or or CC cord-016652-x8t3lf1x 21 31 nucleus nucleus NN cord-016652-x8t3lf1x 21 32 , , , cord-016652-x8t3lf1x 21 33 then then RB cord-016652-x8t3lf1x 21 34 progeny progeny VB cord-016652-x8t3lf1x 21 35 virus virus NN cord-016652-x8t3lf1x 21 36 production production NN cord-016652-x8t3lf1x 21 37 will will MD cord-016652-x8t3lf1x 21 38 be be VB cord-016652-x8t3lf1x 21 39 affected affect VBN cord-016652-x8t3lf1x 21 40 as as IN cord-016652-x8t3lf1x 21 41 has have VBZ cord-016652-x8t3lf1x 21 42 been be VBN cord-016652-x8t3lf1x 21 43 revealed reveal VBN cord-016652-x8t3lf1x 21 44 by by IN cord-016652-x8t3lf1x 21 45 inhibitor inhibitor NN cord-016652-x8t3lf1x 21 46 and and CC cord-016652-x8t3lf1x 21 47 genetic genetic JJ cord-016652-x8t3lf1x 21 48 studies study NNS cord-016652-x8t3lf1x 22 1 ( ( -LRB- cord-016652-x8t3lf1x 22 2 Lee Lee NNP cord-016652-x8t3lf1x 22 3 et et NNP cord-016652-x8t3lf1x 22 4 al al NNP cord-016652-x8t3lf1x 22 5 . . . cord-016652-x8t3lf1x 23 1 2006 2006 CD cord-016652-x8t3lf1x 23 2 ; ; : cord-016652-x8t3lf1x 23 3 Tijms Tijms NNP cord-016652-x8t3lf1x 23 4 et et NNP cord-016652-x8t3lf1x 23 5 al al NNP cord-016652-x8t3lf1x 23 6 . . . cord-016652-x8t3lf1x 23 7 2002 2002 CD cord-016652-x8t3lf1x 23 8 ) ) -RRB- cord-016652-x8t3lf1x 23 9 . . . cord-016652-x8t3lf1x 24 1 Viruses virus NNS cord-016652-x8t3lf1x 24 2 may may MD cord-016652-x8t3lf1x 24 3 interact interact VB cord-016652-x8t3lf1x 24 4 with with IN cord-016652-x8t3lf1x 24 5 the the DT cord-016652-x8t3lf1x 24 6 nucleolus nucleolus NN cord-016652-x8t3lf1x 24 7 to to TO cord-016652-x8t3lf1x 24 8 usurp usurp VB cord-016652-x8t3lf1x 24 9 host host NN cord-016652-x8t3lf1x 24 10 cell cell NN cord-016652-x8t3lf1x 24 11 functions function NNS cord-016652-x8t3lf1x 24 12 and and CC cord-016652-x8t3lf1x 24 13 recruit recruit VB cord-016652-x8t3lf1x 24 14 nucleolar nucleolar JJ cord-016652-x8t3lf1x 24 15 proteins protein NNS cord-016652-x8t3lf1x 24 16 to to TO cord-016652-x8t3lf1x 24 17 facilitate facilitate VB cord-016652-x8t3lf1x 24 18 virus virus NN cord-016652-x8t3lf1x 24 19 replication replication NN cord-016652-x8t3lf1x 24 20 . . . cord-016652-x8t3lf1x 25 1 Investigating investigate VBG cord-016652-x8t3lf1x 25 2 the the DT cord-016652-x8t3lf1x 25 3 interactions interaction NNS cord-016652-x8t3lf1x 25 4 between between IN cord-016652-x8t3lf1x 25 5 viruses virus NNS cord-016652-x8t3lf1x 25 6 and and CC cord-016652-x8t3lf1x 25 7 the the DT cord-016652-x8t3lf1x 25 8 nucleolus nucleolus NN cord-016652-x8t3lf1x 25 9 may may MD cord-016652-x8t3lf1x 25 10 facilitate facilitate VB cord-016652-x8t3lf1x 25 11 the the DT cord-016652-x8t3lf1x 25 12 design design NN cord-016652-x8t3lf1x 25 13 of of IN cord-016652-x8t3lf1x 25 14 novel novel JJ cord-016652-x8t3lf1x 25 15 anti anti JJ cord-016652-x8t3lf1x 25 16 - - JJ cord-016652-x8t3lf1x 25 17 viral viral JJ cord-016652-x8t3lf1x 25 18 therapies therapy NNS cord-016652-x8t3lf1x 25 19 both both CC cord-016652-x8t3lf1x 25 20 in in IN cord-016652-x8t3lf1x 25 21 terms term NNS cord-016652-x8t3lf1x 25 22 of of IN cord-016652-x8t3lf1x 25 23 recombinant recombinant JJ cord-016652-x8t3lf1x 25 24 vaccines vaccine NNS cord-016652-x8t3lf1x 25 25 ( ( -LRB- cord-016652-x8t3lf1x 25 26 Pei Pei NNP cord-016652-x8t3lf1x 25 27 et et NNP cord-016652-x8t3lf1x 25 28 al al NNP cord-016652-x8t3lf1x 25 29 . . NNP cord-016652-x8t3lf1x 25 30 2008 2008 CD cord-016652-x8t3lf1x 25 31 ) ) -RRB- cord-016652-x8t3lf1x 25 32 and and CC cord-016652-x8t3lf1x 25 33 molecular molecular JJ cord-016652-x8t3lf1x 25 34 intervention intervention NN cord-016652-x8t3lf1x 25 35 ( ( -LRB- cord-016652-x8t3lf1x 25 36 Rossi Rossi NNP cord-016652-x8t3lf1x 25 37 et et FW cord-016652-x8t3lf1x 25 38 al al NNP cord-016652-x8t3lf1x 25 39 . . NNP cord-016652-x8t3lf1x 25 40 2007 2007 CD cord-016652-x8t3lf1x 25 41 ) ) -RRB- cord-016652-x8t3lf1x 25 42 , , , cord-016652-x8t3lf1x 25 43 and and CC cord-016652-x8t3lf1x 25 44 also also RB cord-016652-x8t3lf1x 25 45 contribute contribute VB cord-016652-x8t3lf1x 25 46 to to IN cord-016652-x8t3lf1x 25 47 a a DT cord-016652-x8t3lf1x 25 48 more more RBR cord-016652-x8t3lf1x 25 49 detailed detailed JJ cord-016652-x8t3lf1x 25 50 understanding understanding NN cord-016652-x8t3lf1x 25 51 of of IN cord-016652-x8t3lf1x 25 52 the the DT cord-016652-x8t3lf1x 25 53 cell cell NN cord-016652-x8t3lf1x 25 54 biology biology NN cord-016652-x8t3lf1x 25 55 of of IN cord-016652-x8t3lf1x 25 56 the the DT cord-016652-x8t3lf1x 25 57 nucleolus nucleolus NN cord-016652-x8t3lf1x 25 58 . . . cord-016652-x8t3lf1x 26 1 For for IN cord-016652-x8t3lf1x 26 2 many many JJ cord-016652-x8t3lf1x 26 3 years year NNS cord-016652-x8t3lf1x 26 4 our -PRON- PRP$ cord-016652-x8t3lf1x 26 5 understanding understanding NN cord-016652-x8t3lf1x 26 6 of of IN cord-016652-x8t3lf1x 26 7 the the DT cord-016652-x8t3lf1x 26 8 interaction interaction NN cord-016652-x8t3lf1x 26 9 of of IN cord-016652-x8t3lf1x 26 10 viruses virus NNS cord-016652-x8t3lf1x 26 11 and and CC cord-016652-x8t3lf1x 26 12 the the DT cord-016652-x8t3lf1x 26 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 26 14 was be VBD cord-016652-x8t3lf1x 26 15 phenomenological phenomenological JJ cord-016652-x8t3lf1x 26 16 and and CC cord-016652-x8t3lf1x 26 17 focused focus VBN cord-016652-x8t3lf1x 26 18 on on IN cord-016652-x8t3lf1x 26 19 identifying identify VBG cord-016652-x8t3lf1x 26 20 viral viral JJ cord-016652-x8t3lf1x 26 21 proteins protein NNS cord-016652-x8t3lf1x 26 22 that that WDT cord-016652-x8t3lf1x 26 23 localised localise VBD cord-016652-x8t3lf1x 26 24 to to IN cord-016652-x8t3lf1x 26 25 this this DT cord-016652-x8t3lf1x 26 26 structure structure NN cord-016652-x8t3lf1x 26 27 , , , cord-016652-x8t3lf1x 26 28 their -PRON- PRP$ cord-016652-x8t3lf1x 26 29 mechanisms mechanism NNS cord-016652-x8t3lf1x 26 30 of of IN cord-016652-x8t3lf1x 26 31 trafficking trafficking NN cord-016652-x8t3lf1x 26 32 and and CC cord-016652-x8t3lf1x 26 33 potential potential JJ cord-016652-x8t3lf1x 26 34 interaction interaction NN cord-016652-x8t3lf1x 26 35 with with IN cord-016652-x8t3lf1x 26 36 nucleolar nucleolar JJ cord-016652-x8t3lf1x 26 37 proteins protein NNS cord-016652-x8t3lf1x 26 38 ( ( -LRB- cord-016652-x8t3lf1x 26 39 e.g. e.g. RB cord-016652-x8t3lf1x 26 40 see see VBP cord-016652-x8t3lf1x 26 41 Table Table NNP cord-016652-x8t3lf1x 26 42 14 14 CD cord-016652-x8t3lf1x 26 43 .1 .1 CD cord-016652-x8t3lf1x 26 44 ) ) -RRB- cord-016652-x8t3lf1x 26 45 . . . cord-016652-x8t3lf1x 27 1 However however RB cord-016652-x8t3lf1x 27 2 , , , cord-016652-x8t3lf1x 27 3 recent recent JJ cord-016652-x8t3lf1x 27 4 research research NN cord-016652-x8t3lf1x 27 5 capitalising capitalise VBG cord-016652-x8t3lf1x 27 6 on on IN cord-016652-x8t3lf1x 27 7 advances advance NNS cord-016652-x8t3lf1x 27 8 in in IN cord-016652-x8t3lf1x 27 9 proteomics proteomic NNS cord-016652-x8t3lf1x 27 10 , , , cord-016652-x8t3lf1x 27 11 viral viral JJ cord-016652-x8t3lf1x 27 12 genetics genetic NNS cord-016652-x8t3lf1x 27 13 and and CC cord-016652-x8t3lf1x 27 14 cellular cellular JJ cord-016652-x8t3lf1x 27 15 imaging imaging NN cord-016652-x8t3lf1x 27 16 techniques technique NNS cord-016652-x8t3lf1x 27 17 are be VBP cord-016652-x8t3lf1x 27 18 beginning begin VBG cord-016652-x8t3lf1x 27 19 to to TO cord-016652-x8t3lf1x 27 20 increase increase VB cord-016652-x8t3lf1x 27 21 our -PRON- PRP$ cord-016652-x8t3lf1x 27 22 understanding understanding NN cord-016652-x8t3lf1x 27 23 of of IN cord-016652-x8t3lf1x 27 24 the the DT cord-016652-x8t3lf1x 27 25 mechanisms mechanism NNS cord-016652-x8t3lf1x 27 26 viruses virus NNS cord-016652-x8t3lf1x 27 27 use use VBP cord-016652-x8t3lf1x 27 28 to to TO cord-016652-x8t3lf1x 27 29 subvert subvert VB cord-016652-x8t3lf1x 27 30 host host NN cord-016652-x8t3lf1x 27 31 cell cell NN cord-016652-x8t3lf1x 27 32 nucleoli nucleoli NNP cord-016652-x8t3lf1x 27 33 and and CC cord-016652-x8t3lf1x 27 34 facilitate facilitate VB cord-016652-x8t3lf1x 27 35 virus virus NN cord-016652-x8t3lf1x 27 36 biology biology NN cord-016652-x8t3lf1x 27 37 . . . cord-016652-x8t3lf1x 28 1 New new JJ cord-016652-x8t3lf1x 28 2 data datum NNS cord-016652-x8t3lf1x 28 3 are be VBP cord-016652-x8t3lf1x 28 4 now now RB cord-016652-x8t3lf1x 28 5 emerging emerge VBG cord-016652-x8t3lf1x 28 6 that that WDT cord-016652-x8t3lf1x 28 7 support support VBP cord-016652-x8t3lf1x 28 8 the the DT cord-016652-x8t3lf1x 28 9 view view NN cord-016652-x8t3lf1x 28 10 that that IN cord-016652-x8t3lf1x 28 11 many many JJ cord-016652-x8t3lf1x 28 12 viruses virus NNS cord-016652-x8t3lf1x 28 13 interact interact VBP cord-016652-x8t3lf1x 28 14 with with IN cord-016652-x8t3lf1x 28 15 the the DT cord-016652-x8t3lf1x 28 16 nucleus nucleus NN cord-016652-x8t3lf1x 28 17 and and CC cord-016652-x8t3lf1x 28 18 nucleolus nucleolus NN cord-016652-x8t3lf1x 28 19 , , , cord-016652-x8t3lf1x 28 20 particularly particularly RB cord-016652-x8t3lf1x 28 21 to to TO cord-016652-x8t3lf1x 28 22 facilitate facilitate VB cord-016652-x8t3lf1x 28 23 virus virus NN cord-016652-x8t3lf1x 28 24 replication replication NN cord-016652-x8t3lf1x 28 25 . . . cord-016652-x8t3lf1x 29 1 One one CD cord-016652-x8t3lf1x 29 2 of of IN cord-016652-x8t3lf1x 29 3 the the DT cord-016652-x8t3lf1x 29 4 best well RBS cord-016652-x8t3lf1x 29 5 - - HYPH cord-016652-x8t3lf1x 29 6 studied study VBN cord-016652-x8t3lf1x 29 7 viruses virus NNS cord-016652-x8t3lf1x 29 8 in in IN cord-016652-x8t3lf1x 29 9 terms term NNS cord-016652-x8t3lf1x 29 10 of of IN cord-016652-x8t3lf1x 29 11 viral viral JJ cord-016652-x8t3lf1x 29 12 interactions interaction NNS cord-016652-x8t3lf1x 29 13 with with IN cord-016652-x8t3lf1x 29 14 the the DT cord-016652-x8t3lf1x 29 15 nucleolus nucleolus NN cord-016652-x8t3lf1x 29 16 is be VBZ cord-016652-x8t3lf1x 29 17 HIV-1 HIV-1 NNP cord-016652-x8t3lf1x 29 18 and and CC cord-016652-x8t3lf1x 29 19 is be VBZ cord-016652-x8t3lf1x 29 20 described describe VBN cord-016652-x8t3lf1x 29 21 in in IN cord-016652-x8t3lf1x 29 22 detail detail NN cord-016652-x8t3lf1x 29 23 in in IN cord-016652-x8t3lf1x 29 24 Chap Chap NNP cord-016652-x8t3lf1x 29 25 . . . cord-016652-x8t3lf1x 30 1 17 17 CD cord-016652-x8t3lf1x 30 2 . . . cord-016652-x8t3lf1x 31 1 Although although IN cord-016652-x8t3lf1x 31 2 HIV HIV NNP cord-016652-x8t3lf1x 31 3 has have VBZ cord-016652-x8t3lf1x 31 4 clearly clearly RB cord-016652-x8t3lf1x 31 5 defined define VBN cord-016652-x8t3lf1x 31 6 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 31 7 and and CC cord-016652-x8t3lf1x 31 8 nuclear nuclear JJ cord-016652-x8t3lf1x 31 9 replication replication NN cord-016652-x8t3lf1x 31 10 strategies strategy NNS cord-016652-x8t3lf1x 31 11 , , , cord-016652-x8t3lf1x 31 12 the the DT cord-016652-x8t3lf1x 31 13 virus virus NN cord-016652-x8t3lf1x 31 14 has have VBZ cord-016652-x8t3lf1x 31 15 a a DT cord-016652-x8t3lf1x 31 16 positive positive JJ cord-016652-x8t3lf1x 31 17 - - HYPH cord-016652-x8t3lf1x 31 18 sense sense NN cord-016652-x8t3lf1x 31 19 RNA RNA NNP cord-016652-x8t3lf1x 31 20 genome genome NN cord-016652-x8t3lf1x 31 21 in in IN cord-016652-x8t3lf1x 31 22 the the DT cord-016652-x8t3lf1x 31 23 sense sense NN cord-016652-x8t3lf1x 31 24 that that IN cord-016652-x8t3lf1x 31 25 the the DT cord-016652-x8t3lf1x 31 26 viral viral JJ cord-016652-x8t3lf1x 31 27 capsid capsid NN cord-016652-x8t3lf1x 31 28 contains contain VBZ cord-016652-x8t3lf1x 31 29 two two CD cord-016652-x8t3lf1x 31 30 copies copy NNS cord-016652-x8t3lf1x 31 31 of of IN cord-016652-x8t3lf1x 31 32 positive positive JJ cord-016652-x8t3lf1x 31 33 - - HYPH cord-016652-x8t3lf1x 31 34 sense sense NN cord-016652-x8t3lf1x 31 35 RNA RNA NNP cord-016652-x8t3lf1x 31 36 , , , cord-016652-x8t3lf1x 31 37 but but CC cord-016652-x8t3lf1x 31 38 these these DT cord-016652-x8t3lf1x 31 39 are be VBP cord-016652-x8t3lf1x 31 40 reverse reverse JJ cord-016652-x8t3lf1x 31 41 transcribed transcribe VBN cord-016652-x8t3lf1x 31 42 in in IN cord-016652-x8t3lf1x 31 43 the the DT cord-016652-x8t3lf1x 31 44 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 31 45 and and CC cord-016652-x8t3lf1x 31 46 then then RB cord-016652-x8t3lf1x 31 47 trafficked traffic VBN cord-016652-x8t3lf1x 31 48 to to IN cord-016652-x8t3lf1x 31 49 the the DT cord-016652-x8t3lf1x 31 50 nucleus nucleus NN cord-016652-x8t3lf1x 31 51 , , , cord-016652-x8t3lf1x 31 52 where where WRB cord-016652-x8t3lf1x 31 53 ultimately ultimately RB cord-016652-x8t3lf1x 31 54 the the DT cord-016652-x8t3lf1x 31 55 new new JJ cord-016652-x8t3lf1x 31 56 genome genome NN cord-016652-x8t3lf1x 31 57 is be VBZ cord-016652-x8t3lf1x 31 58 transcribed transcribe VBN cord-016652-x8t3lf1x 31 59 and and CC cord-016652-x8t3lf1x 31 60 trafficked traffic VBN cord-016652-x8t3lf1x 31 61 back back RB cord-016652-x8t3lf1x 31 62 to to IN cord-016652-x8t3lf1x 31 63 the the DT cord-016652-x8t3lf1x 31 64 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 31 65 . . . cord-016652-x8t3lf1x 32 1 Part part NN cord-016652-x8t3lf1x 32 2 of of IN cord-016652-x8t3lf1x 32 3 the the DT cord-016652-x8t3lf1x 32 4 reasoning reasoning NN cord-016652-x8t3lf1x 32 5 for for IN cord-016652-x8t3lf1x 32 6 the the DT cord-016652-x8t3lf1x 32 7 interaction interaction NN cord-016652-x8t3lf1x 32 8 of of IN cord-016652-x8t3lf1x 32 9 HIV-1 HIV-1 NNP cord-016652-x8t3lf1x 32 10 with with IN cord-016652-x8t3lf1x 32 11 the the DT cord-016652-x8t3lf1x 32 12 nucleolus nucleolus NN cord-016652-x8t3lf1x 32 13 is be VBZ cord-016652-x8t3lf1x 32 14 the the DT cord-016652-x8t3lf1x 32 15 trafficking trafficking NN cord-016652-x8t3lf1x 32 16 of of IN cord-016652-x8t3lf1x 32 17 intronless intronless NNP cord-016652-x8t3lf1x 32 18 mRNA mrna NN cord-016652-x8t3lf1x 32 19 from from IN cord-016652-x8t3lf1x 32 20 the the DT cord-016652-x8t3lf1x 32 21 nucleus nucleus NN cord-016652-x8t3lf1x 32 22 into into IN cord-016652-x8t3lf1x 32 23 the the DT cord-016652-x8t3lf1x 32 24 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 33 1 ( ( -LRB- cord-016652-x8t3lf1x 33 2 Michienzi Michienzi NNP cord-016652-x8t3lf1x 33 3 et et NNP cord-016652-x8t3lf1x 33 4 al al NNP cord-016652-x8t3lf1x 33 5 . . . cord-016652-x8t3lf1x 33 6 2000 2000 CD cord-016652-x8t3lf1x 33 7 ) ) -RRB- cord-016652-x8t3lf1x 33 8 . . . cord-016652-x8t3lf1x 34 1 This this DT cord-016652-x8t3lf1x 34 2 is be VBZ cord-016652-x8t3lf1x 34 3 a a DT cord-016652-x8t3lf1x 34 4 property property NN cord-016652-x8t3lf1x 34 5 shared share VBN cord-016652-x8t3lf1x 34 6 with with IN cord-016652-x8t3lf1x 34 7 herpes herpes NN cord-016652-x8t3lf1x 34 8 viruses virus NNS cord-016652-x8t3lf1x 34 9 and and CC cord-016652-x8t3lf1x 34 10 indicated indicate VBD cord-016652-x8t3lf1x 34 11 that that IN cord-016652-x8t3lf1x 34 12 different different JJ cord-016652-x8t3lf1x 34 13 viruses virus NNS cord-016652-x8t3lf1x 34 14 have have VBP cord-016652-x8t3lf1x 34 15 evolved evolve VBN cord-016652-x8t3lf1x 34 16 similar similar JJ cord-016652-x8t3lf1x 34 17 strategies strategy NNS cord-016652-x8t3lf1x 34 18 involving involve VBG cord-016652-x8t3lf1x 34 19 subversion subversion NN cord-016652-x8t3lf1x 34 20 of of IN cord-016652-x8t3lf1x 34 21 nucleolar nucleolar JJ cord-016652-x8t3lf1x 34 22 function function NN cord-016652-x8t3lf1x 34 23 for for IN cord-016652-x8t3lf1x 34 24 the the DT cord-016652-x8t3lf1x 34 25 benefit benefit NN cord-016652-x8t3lf1x 34 26 of of IN cord-016652-x8t3lf1x 34 27 virus virus NN cord-016652-x8t3lf1x 34 28 biology biology NN cord-016652-x8t3lf1x 34 29 ( ( -LRB- cord-016652-x8t3lf1x 34 30 Boyne Boyne NNP cord-016652-x8t3lf1x 34 31 and and CC cord-016652-x8t3lf1x 34 32 Whitehouse Whitehouse NNP cord-016652-x8t3lf1x 34 33 2006 2006 CD cord-016652-x8t3lf1x 34 34 ) ) -RRB- cord-016652-x8t3lf1x 34 35 . . . cord-016652-x8t3lf1x 35 1 In in IN cord-016652-x8t3lf1x 35 2 the the DT cord-016652-x8t3lf1x 35 3 case case NN cord-016652-x8t3lf1x 35 4 of of IN cord-016652-x8t3lf1x 35 5 HIV-1 HIV-1 NNP cord-016652-x8t3lf1x 35 6 , , , cord-016652-x8t3lf1x 35 7 this this DT cord-016652-x8t3lf1x 35 8 knowledge knowledge NN cord-016652-x8t3lf1x 35 9 has have VBZ cord-016652-x8t3lf1x 35 10 also also RB cord-016652-x8t3lf1x 35 11 led lead VBN cord-016652-x8t3lf1x 35 12 to to IN cord-016652-x8t3lf1x 35 13 the the DT cord-016652-x8t3lf1x 35 14 design design NN cord-016652-x8t3lf1x 35 15 and and CC cord-016652-x8t3lf1x 35 16 implementation implementation NN cord-016652-x8t3lf1x 35 17 of of IN cord-016652-x8t3lf1x 35 18 effective effective JJ cord-016652-x8t3lf1x 35 19 genetic genetic JJ cord-016652-x8t3lf1x 35 20 therapies therapy NNS cord-016652-x8t3lf1x 35 21 against against IN cord-016652-x8t3lf1x 35 22 the the DT cord-016652-x8t3lf1x 35 23 virus virus NN cord-016652-x8t3lf1x 35 24 ( ( -LRB- cord-016652-x8t3lf1x 35 25 Unwalla Unwalla NNP cord-016652-x8t3lf1x 35 26 et et NNP cord-016652-x8t3lf1x 35 27 al al NNP cord-016652-x8t3lf1x 35 28 . . NNP cord-016652-x8t3lf1x 35 29 2008 2008 CD cord-016652-x8t3lf1x 35 30 ) ) -RRB- cord-016652-x8t3lf1x 35 31 . . . cord-016652-x8t3lf1x 36 1 A a DT cord-016652-x8t3lf1x 36 2 large large JJ cord-016652-x8t3lf1x 36 3 number number NN cord-016652-x8t3lf1x 36 4 of of IN cord-016652-x8t3lf1x 36 5 viruses virus NNS cord-016652-x8t3lf1x 36 6 with with IN cord-016652-x8t3lf1x 36 7 DNA dna NN cord-016652-x8t3lf1x 36 8 genomes genome NNS cord-016652-x8t3lf1x 36 9 have have VBP cord-016652-x8t3lf1x 36 10 been be VBN cord-016652-x8t3lf1x 36 11 shown show VBN cord-016652-x8t3lf1x 36 12 to to TO cord-016652-x8t3lf1x 36 13 interact interact VB cord-016652-x8t3lf1x 36 14 with with IN cord-016652-x8t3lf1x 36 15 nucleolus nucleolus NN cord-016652-x8t3lf1x 36 16 , , , cord-016652-x8t3lf1x 36 17 and and CC cord-016652-x8t3lf1x 36 18 this this DT cord-016652-x8t3lf1x 36 19 perhaps perhaps RB cord-016652-x8t3lf1x 36 20 is be VBZ cord-016652-x8t3lf1x 36 21 not not RB cord-016652-x8t3lf1x 36 22 surprising surprising JJ cord-016652-x8t3lf1x 36 23 as as IN cord-016652-x8t3lf1x 36 24 most most JJS cord-016652-x8t3lf1x 36 25 DNA dna NN cord-016652-x8t3lf1x 36 26 viruses virus NNS cord-016652-x8t3lf1x 36 27 replicate replicate VBP cord-016652-x8t3lf1x 36 28 in in IN cord-016652-x8t3lf1x 36 29 the the DT cord-016652-x8t3lf1x 36 30 nucleus nucleus NN cord-016652-x8t3lf1x 36 31 . . . cord-016652-x8t3lf1x 37 1 A a DT cord-016652-x8t3lf1x 37 2 genome genome NN cord-016652-x8t3lf1x 37 3 - - HYPH cord-016652-x8t3lf1x 37 4 wide wide JJ cord-016652-x8t3lf1x 37 5 screen screen NN cord-016652-x8t3lf1x 37 6 of of IN cord-016652-x8t3lf1x 37 7 three three CD cord-016652-x8t3lf1x 37 8 distinct distinct JJ cord-016652-x8t3lf1x 37 9 herpesviruses herpesviruse NNS cord-016652-x8t3lf1x 37 10 , , , cord-016652-x8t3lf1x 37 11 herpes herpes NN cord-016652-x8t3lf1x 37 12 simplex simplex NNP cord-016652-x8t3lf1x 37 13 virus virus NN cord-016652-x8t3lf1x 37 14 1 1 CD cord-016652-x8t3lf1x 37 15 ( ( -LRB- cord-016652-x8t3lf1x 37 16 HSV-1 HSV-1 NNP cord-016652-x8t3lf1x 37 17 ) ) -RRB- cord-016652-x8t3lf1x 37 18 , , , cord-016652-x8t3lf1x 37 19 cytomegalovirus cytomegalovirus NNP cord-016652-x8t3lf1x 37 20 ( ( -LRB- cord-016652-x8t3lf1x 37 21 CMV CMV NNP cord-016652-x8t3lf1x 37 22 ) ) -RRB- cord-016652-x8t3lf1x 37 23 and and CC cord-016652-x8t3lf1x 37 24 Epstein Epstein NNP cord-016652-x8t3lf1x 37 25 - - HYPH cord-016652-x8t3lf1x 37 26 Barr Barr NNP cord-016652-x8t3lf1x 37 27 virus virus NN cord-016652-x8t3lf1x 37 28 ( ( -LRB- cord-016652-x8t3lf1x 37 29 EBV EBV NNP cord-016652-x8t3lf1x 37 30 ) ) -RRB- cord-016652-x8t3lf1x 37 31 , , , cord-016652-x8t3lf1x 37 32 has have VBZ cord-016652-x8t3lf1x 37 33 shown show VBN cord-016652-x8t3lf1x 37 34 that that IN cord-016652-x8t3lf1x 37 35 at at RB cord-016652-x8t3lf1x 37 36 least least RBS cord-016652-x8t3lf1x 37 37 12 12 CD cord-016652-x8t3lf1x 37 38 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 37 39 - - HYPH cord-016652-x8t3lf1x 37 40 encoded encode VBN cord-016652-x8t3lf1x 37 41 proteins protein NNS cord-016652-x8t3lf1x 37 42 specifically specifically RB cord-016652-x8t3lf1x 37 43 localise localise VBP cord-016652-x8t3lf1x 37 44 to to IN cord-016652-x8t3lf1x 37 45 the the DT cord-016652-x8t3lf1x 37 46 nucleolus nucleolus NN cord-016652-x8t3lf1x 37 47 ( ( -LRB- cord-016652-x8t3lf1x 37 48 Salsman Salsman NNP cord-016652-x8t3lf1x 37 49 et et NNP cord-016652-x8t3lf1x 37 50 al al NNP cord-016652-x8t3lf1x 37 51 . . NNP cord-016652-x8t3lf1x 37 52 2008 2008 CD cord-016652-x8t3lf1x 37 53 ) ) -RRB- cord-016652-x8t3lf1x 37 54 , , , cord-016652-x8t3lf1x 37 55 which which WDT cord-016652-x8t3lf1x 37 56 are be VBP cord-016652-x8t3lf1x 37 57 implicated implicate VBN cord-016652-x8t3lf1x 37 58 in in IN cord-016652-x8t3lf1x 37 59 many many JJ cord-016652-x8t3lf1x 37 60 aspects aspect NNS cord-016652-x8t3lf1x 37 61 of of IN cord-016652-x8t3lf1x 37 62 the the DT cord-016652-x8t3lf1x 37 63 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 37 64 life life NN cord-016652-x8t3lf1x 37 65 cycle cycle NN cord-016652-x8t3lf1x 37 66 . . . cord-016652-x8t3lf1x 38 1 Therefore therefore RB cord-016652-x8t3lf1x 38 2 , , , cord-016652-x8t3lf1x 38 3 a a DT cord-016652-x8t3lf1x 38 4 number number NN cord-016652-x8t3lf1x 38 5 of of IN cord-016652-x8t3lf1x 38 6 proteomic proteomic JJ cord-016652-x8t3lf1x 38 7 studies study NNS cord-016652-x8t3lf1x 38 8 are be VBP cord-016652-x8t3lf1x 38 9 currently currently RB cord-016652-x8t3lf1x 38 10 being be VBG cord-016652-x8t3lf1x 38 11 undertaken undertake VBN cord-016652-x8t3lf1x 38 12 to to TO cord-016652-x8t3lf1x 38 13 study study VB cord-016652-x8t3lf1x 38 14 changes change NNS cord-016652-x8t3lf1x 38 15 , , , cord-016652-x8t3lf1x 38 16 in in IN cord-016652-x8t3lf1x 38 17 a a DT cord-016652-x8t3lf1x 38 18 global global JJ cord-016652-x8t3lf1x 38 19 context context NN cord-016652-x8t3lf1x 38 20 , , , cord-016652-x8t3lf1x 38 21 within within IN cord-016652-x8t3lf1x 38 22 the the DT cord-016652-x8t3lf1x 38 23 nucleolar nucleolar JJ cord-016652-x8t3lf1x 38 24 proteome proteome NN cord-016652-x8t3lf1x 38 25 during during IN cord-016652-x8t3lf1x 38 26 virus virus NN cord-016652-x8t3lf1x 38 27 infections infection NNS cord-016652-x8t3lf1x 38 28 , , , cord-016652-x8t3lf1x 38 29 and and CC cord-016652-x8t3lf1x 38 30 are be VBP cord-016652-x8t3lf1x 38 31 discussed discuss VBN cord-016652-x8t3lf1x 38 32 later later RB cord-016652-x8t3lf1x 39 1 ( ( -LRB- cord-016652-x8t3lf1x 39 2 Lam Lam NNP cord-016652-x8t3lf1x 39 3 et et FW cord-016652-x8t3lf1x 39 4 al al NNP cord-016652-x8t3lf1x 39 5 . . NNP cord-016652-x8t3lf1x 39 6 2010 2010 CD cord-016652-x8t3lf1x 39 7 ) ) -RRB- cord-016652-x8t3lf1x 39 8 . . . cord-016652-x8t3lf1x 40 1 Several several JJ cord-016652-x8t3lf1x 40 2 different different JJ cord-016652-x8t3lf1x 40 3 herpes herpe NNS cord-016652-x8t3lf1x 40 4 virus virus NN cord-016652-x8t3lf1x 40 5 proteins protein NNS cord-016652-x8t3lf1x 40 6 have have VBP cord-016652-x8t3lf1x 40 7 been be VBN cord-016652-x8t3lf1x 40 8 shown show VBN cord-016652-x8t3lf1x 40 9 to to TO cord-016652-x8t3lf1x 40 10 cause cause VB cord-016652-x8t3lf1x 40 11 the the DT cord-016652-x8t3lf1x 40 12 redistribution redistribution NN cord-016652-x8t3lf1x 40 13 of of IN cord-016652-x8t3lf1x 40 14 nucleolar nucleolar JJ cord-016652-x8t3lf1x 40 15 proteins protein NNS cord-016652-x8t3lf1x 40 16 and and CC cord-016652-x8t3lf1x 40 17 hence hence RB cord-016652-x8t3lf1x 40 18 disruption disruption NN cord-016652-x8t3lf1x 40 19 of of IN cord-016652-x8t3lf1x 40 20 the the DT cord-016652-x8t3lf1x 40 21 nucleolus nucleolus NN cord-016652-x8t3lf1x 40 22 . . . cord-016652-x8t3lf1x 41 1 These these DT cord-016652-x8t3lf1x 41 2 include include VBP cord-016652-x8t3lf1x 41 3 herpes herpes NN cord-016652-x8t3lf1x 41 4 simplex simplex NN cord-016652-x8t3lf1x 41 5 virus virus NN cord-016652-x8t3lf1x 41 6 1 1 CD cord-016652-x8t3lf1x 41 7 , , , cord-016652-x8t3lf1x 41 8 the the DT cord-016652-x8t3lf1x 41 9 major major JJ cord-016652-x8t3lf1x 41 10 tegument tegument NNP cord-016652-x8t3lf1x 41 11 structural structural JJ cord-016652-x8t3lf1x 41 12 protein protein NN cord-016652-x8t3lf1x 42 1 VP22 VP22 NNP cord-016652-x8t3lf1x 43 1 ( ( -LRB- cord-016652-x8t3lf1x 43 2 Lopez Lopez NNP cord-016652-x8t3lf1x 43 3 et et NNP cord-016652-x8t3lf1x 43 4 al al NNP cord-016652-x8t3lf1x 43 5 . . NNP cord-016652-x8t3lf1x 43 6 2008 2008 CD cord-016652-x8t3lf1x 43 7 ) ) -RRB- cord-016652-x8t3lf1x 43 8 , , , cord-016652-x8t3lf1x 43 9 and and CC cord-016652-x8t3lf1x 43 10 the the DT cord-016652-x8t3lf1x 43 11 US11 US11 NNP cord-016652-x8t3lf1x 43 12 ( ( -LRB- cord-016652-x8t3lf1x 43 13 Xing Xing NNP cord-016652-x8t3lf1x 43 14 et et FW cord-016652-x8t3lf1x 43 15 al al NNP cord-016652-x8t3lf1x 43 16 . . NNP cord-016652-x8t3lf1x 43 17 2010 2010 CD cord-016652-x8t3lf1x 43 18 ) ) -RRB- cord-016652-x8t3lf1x 44 1 and and CC cord-016652-x8t3lf1x 44 2 UL24 UL24 NNP cord-016652-x8t3lf1x 44 3 proteins protein NNS cord-016652-x8t3lf1x 44 4 ( ( -LRB- cord-016652-x8t3lf1x 44 5 Bertrand Bertrand NNP cord-016652-x8t3lf1x 44 6 and and CC cord-016652-x8t3lf1x 44 7 Pearson Pearson NNP cord-016652-x8t3lf1x 44 8 2008 2008 CD cord-016652-x8t3lf1x 44 9 ; ; : cord-016652-x8t3lf1x 45 1 Lymberopoulos Lymberopoulos NNP cord-016652-x8t3lf1x 45 2 and and CC cord-016652-x8t3lf1x 45 3 Pearson Pearson NNP cord-016652-x8t3lf1x 45 4 2007 2007 CD cord-016652-x8t3lf1x 45 5 ) ) -RRB- cord-016652-x8t3lf1x 45 6 . . . cord-016652-x8t3lf1x 46 1 Such such JJ cord-016652-x8t3lf1x 46 2 disruption disruption NN cord-016652-x8t3lf1x 46 3 in in IN cord-016652-x8t3lf1x 46 4 many many JJ cord-016652-x8t3lf1x 46 5 cases case NNS cord-016652-x8t3lf1x 46 6 may may MD cord-016652-x8t3lf1x 46 7 have have VB cord-016652-x8t3lf1x 46 8 a a DT cord-016652-x8t3lf1x 46 9 direct direct JJ cord-016652-x8t3lf1x 46 10 effect effect NN cord-016652-x8t3lf1x 46 11 on on IN cord-016652-x8t3lf1x 46 12 nucleolar nucleolar JJ cord-016652-x8t3lf1x 46 13 function function NN cord-016652-x8t3lf1x 46 14 . . . cord-016652-x8t3lf1x 47 1 A a DT cord-016652-x8t3lf1x 47 2 significant significant JJ cord-016652-x8t3lf1x 47 3 area area NN cord-016652-x8t3lf1x 47 4 of of IN cord-016652-x8t3lf1x 47 5 virus virus NN cord-016652-x8t3lf1x 47 6 biology biology NN cord-016652-x8t3lf1x 47 7 that that WDT cord-016652-x8t3lf1x 47 8 has have VBZ cord-016652-x8t3lf1x 47 9 been be VBN cord-016652-x8t3lf1x 47 10 investigated investigate VBN cord-016652-x8t3lf1x 47 11 is be VBZ cord-016652-x8t3lf1x 47 12 the the DT cord-016652-x8t3lf1x 47 13 role role NN cord-016652-x8t3lf1x 47 14 of of IN cord-016652-x8t3lf1x 47 15 viral viral JJ cord-016652-x8t3lf1x 47 16 proteins protein NNS cord-016652-x8t3lf1x 47 17 that that WDT cord-016652-x8t3lf1x 47 18 traffic traffic NN cord-016652-x8t3lf1x 47 19 through through IN cord-016652-x8t3lf1x 47 20 the the DT cord-016652-x8t3lf1x 47 21 nucleolus nucleolus NN cord-016652-x8t3lf1x 47 22 . . . cord-016652-x8t3lf1x 48 1 For for IN cord-016652-x8t3lf1x 48 2 example example NN cord-016652-x8t3lf1x 48 3 , , , cord-016652-x8t3lf1x 48 4 a a DT cord-016652-x8t3lf1x 48 5 number number NN cord-016652-x8t3lf1x 48 6 of of IN cord-016652-x8t3lf1x 48 7 HIV HIV NNP cord-016652-x8t3lf1x 48 8 proteins protein NNS cord-016652-x8t3lf1x 48 9 that that IN cord-016652-x8t3lf1x 48 10 traffic traffic NN cord-016652-x8t3lf1x 48 11 through through IN cord-016652-x8t3lf1x 48 12 the the DT cord-016652-x8t3lf1x 48 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 48 14 have have VBP cord-016652-x8t3lf1x 48 15 been be VBN cord-016652-x8t3lf1x 48 16 implicated implicate VBN cord-016652-x8t3lf1x 48 17 in in IN cord-016652-x8t3lf1x 48 18 virus virus NN cord-016652-x8t3lf1x 48 19 mRNA mrna NN cord-016652-x8t3lf1x 48 20 processing processing NN cord-016652-x8t3lf1x 48 21 ( ( -LRB- cord-016652-x8t3lf1x 48 22 Dundr Dundr NNP cord-016652-x8t3lf1x 48 23 et et NNP cord-016652-x8t3lf1x 48 24 al al NNP cord-016652-x8t3lf1x 48 25 . . NNP cord-016652-x8t3lf1x 48 26 1995 1995 CD cord-016652-x8t3lf1x 48 27 ) ) -RRB- cord-016652-x8t3lf1x 48 28 . . . cord-016652-x8t3lf1x 49 1 Similar similar JJ cord-016652-x8t3lf1x 49 2 observations observation NNS cord-016652-x8t3lf1x 49 3 have have VBP cord-016652-x8t3lf1x 49 4 also also RB cord-016652-x8t3lf1x 49 5 been be VBN cord-016652-x8t3lf1x 49 6 made make VBN cord-016652-x8t3lf1x 49 7 in in IN cord-016652-x8t3lf1x 49 8 herpesviruses herpesviruses NNP cord-016652-x8t3lf1x 49 9 Whitehouse Whitehouse NNP cord-016652-x8t3lf1x 49 10 2006 2006 CD cord-016652-x8t3lf1x 49 11 , , , cord-016652-x8t3lf1x 49 12 2009 2009 CD cord-016652-x8t3lf1x 49 13 ; ; : cord-016652-x8t3lf1x 49 14 Leenadevi Leenadevi NNP cord-016652-x8t3lf1x 49 15 and and CC cord-016652-x8t3lf1x 49 16 Dalziel Dalziel NNP cord-016652-x8t3lf1x 49 17 2009 2009 CD cord-016652-x8t3lf1x 49 18 ) ) -RRB- cord-016652-x8t3lf1x 49 19 . . . cord-016652-x8t3lf1x 50 1 Initial initial JJ cord-016652-x8t3lf1x 50 2 studies study NNS cord-016652-x8t3lf1x 50 3 utilising utilise VBG cord-016652-x8t3lf1x 50 4 the the DT cord-016652-x8t3lf1x 50 5 prototype prototype NN cord-016652-x8t3lf1x 50 6 g-2 g-2 NN cord-016652-x8t3lf1x 50 7 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 50 8 , , , cord-016652-x8t3lf1x 50 9 herpes herpes NNP cord-016652-x8t3lf1x 50 10 virus virus NN cord-016652-x8t3lf1x 50 11 saimiri saimiri NNP cord-016652-x8t3lf1x 50 12 ( ( -LRB- cord-016652-x8t3lf1x 50 13 HVS HVS NNP cord-016652-x8t3lf1x 50 14 ) ) -RRB- cord-016652-x8t3lf1x 50 15 , , , cord-016652-x8t3lf1x 50 16 demonstrated demonstrate VBD cord-016652-x8t3lf1x 50 17 that that IN cord-016652-x8t3lf1x 50 18 the the DT cord-016652-x8t3lf1x 50 19 HVS HVS NNP cord-016652-x8t3lf1x 50 20 nucleolar nucleolar NN cord-016652-x8t3lf1x 50 21 trafficking traffic VBG cord-016652-x8t3lf1x 50 22 ORF57 ORF57 NNP cord-016652-x8t3lf1x 50 23 protein protein NN cord-016652-x8t3lf1x 50 24 induces induce VBZ cord-016652-x8t3lf1x 50 25 nucleolar nucleolar JJ cord-016652-x8t3lf1x 50 26 redistribution redistribution NN cord-016652-x8t3lf1x 50 27 of of IN cord-016652-x8t3lf1x 50 28 the the DT cord-016652-x8t3lf1x 50 29 host host NN cord-016652-x8t3lf1x 50 30 cell cell NN cord-016652-x8t3lf1x 50 31 human human JJ cord-016652-x8t3lf1x 50 32 TREX TREX NNP cord-016652-x8t3lf1x 50 33 proteins protein NNS cord-016652-x8t3lf1x 50 34 , , , cord-016652-x8t3lf1x 50 35 which which WDT cord-016652-x8t3lf1x 50 36 are be VBP cord-016652-x8t3lf1x 50 37 involved involve VBN cord-016652-x8t3lf1x 50 38 in in IN cord-016652-x8t3lf1x 50 39 mRNA mRNA NNP cord-016652-x8t3lf1x 50 40 nuclear nuclear JJ cord-016652-x8t3lf1x 50 41 export export NN cord-016652-x8t3lf1x 50 42 ( ( -LRB- cord-016652-x8t3lf1x 50 43 Boyne Boyne NNP cord-016652-x8t3lf1x 50 44 and and CC cord-016652-x8t3lf1x 50 45 Whitehouse Whitehouse NNP cord-016652-x8t3lf1x 50 46 2006 2006 CD cord-016652-x8t3lf1x 50 47 ) ) -RRB- cord-016652-x8t3lf1x 50 48 . . . cord-016652-x8t3lf1x 51 1 Intriguingly intriguingly RB cord-016652-x8t3lf1x 51 2 , , , cord-016652-x8t3lf1x 51 3 ablating ablate VBG cord-016652-x8t3lf1x 51 4 ORF57 ORF57 NNP cord-016652-x8t3lf1x 51 5 nucleolar nucleolar JJ cord-016652-x8t3lf1x 51 6 trafficking trafficking NN cord-016652-x8t3lf1x 51 7 led lead VBD cord-016652-x8t3lf1x 51 8 to to IN cord-016652-x8t3lf1x 51 9 a a DT cord-016652-x8t3lf1x 51 10 failure failure NN cord-016652-x8t3lf1x 51 11 of of IN cord-016652-x8t3lf1x 51 12 ORF57-mediated orf57-mediated JJ cord-016652-x8t3lf1x 51 13 viral viral JJ cord-016652-x8t3lf1x 51 14 mRNA mRNA NNP cord-016652-x8t3lf1x 51 15 nuclear nuclear JJ cord-016652-x8t3lf1x 51 16 export export NN cord-016652-x8t3lf1x 51 17 ( ( -LRB- cord-016652-x8t3lf1x 51 18 Boyne Boyne NNP cord-016652-x8t3lf1x 51 19 and and CC cord-016652-x8t3lf1x 51 20 Whitehouse Whitehouse NNP cord-016652-x8t3lf1x 51 21 2006 2006 CD cord-016652-x8t3lf1x 51 22 ) ) -RRB- cord-016652-x8t3lf1x 51 23 . . . cord-016652-x8t3lf1x 52 1 The the DT cord-016652-x8t3lf1x 52 2 precise precise JJ cord-016652-x8t3lf1x 52 3 role role NN cord-016652-x8t3lf1x 52 4 of of IN cord-016652-x8t3lf1x 52 5 this this DT cord-016652-x8t3lf1x 52 6 nucleolar nucleolar JJ cord-016652-x8t3lf1x 52 7 sequestration sequestration NN cord-016652-x8t3lf1x 52 8 is be VBZ cord-016652-x8t3lf1x 52 9 yet yet RB cord-016652-x8t3lf1x 52 10 to to TO cord-016652-x8t3lf1x 52 11 be be VB cord-016652-x8t3lf1x 52 12 determined determine VBN cord-016652-x8t3lf1x 52 13 , , , cord-016652-x8t3lf1x 52 14 but but CC cord-016652-x8t3lf1x 52 15 possible possible JJ cord-016652-x8t3lf1x 52 16 effects effect NNS cord-016652-x8t3lf1x 52 17 on on IN cord-016652-x8t3lf1x 52 18 viral viral JJ cord-016652-x8t3lf1x 52 19 mRNA mrna NN cord-016652-x8t3lf1x 52 20 / / SYM cord-016652-x8t3lf1x 52 21 protein protein NN cord-016652-x8t3lf1x 52 22 processing processing NN cord-016652-x8t3lf1x 52 23 and and CC cord-016652-x8t3lf1x 52 24 viral viral JJ cord-016652-x8t3lf1x 52 25 ribonucleoprotein ribonucleoprotein NN cord-016652-x8t3lf1x 52 26 particle particle NN cord-016652-x8t3lf1x 52 27 assembly assembly NN cord-016652-x8t3lf1x 52 28 are be VBP cord-016652-x8t3lf1x 52 29 currently currently RB cord-016652-x8t3lf1x 52 30 being be VBG cord-016652-x8t3lf1x 52 31 investigated investigate VBN cord-016652-x8t3lf1x 52 32 . . . cord-016652-x8t3lf1x 53 1 This this DT cord-016652-x8t3lf1x 53 2 property property NN cord-016652-x8t3lf1x 53 3 may may MD cord-016652-x8t3lf1x 53 4 also also RB cord-016652-x8t3lf1x 53 5 be be VB cord-016652-x8t3lf1x 53 6 conserved conserve VBN cord-016652-x8t3lf1x 53 7 in in IN cord-016652-x8t3lf1x 53 8 other other JJ cord-016652-x8t3lf1x 53 9 ORF57 ORF57 NNP cord-016652-x8t3lf1x 53 10 homologues homologue NNS cord-016652-x8t3lf1x 53 11 as as IN cord-016652-x8t3lf1x 53 12 recent recent JJ cord-016652-x8t3lf1x 53 13 analysis analysis NN cord-016652-x8t3lf1x 53 14 has have VBZ cord-016652-x8t3lf1x 53 15 shown show VBN cord-016652-x8t3lf1x 53 16 that that IN cord-016652-x8t3lf1x 53 17 the the DT cord-016652-x8t3lf1x 53 18 ORF57 ORF57 NNP cord-016652-x8t3lf1x 53 19 protein protein NN cord-016652-x8t3lf1x 53 20 from from IN cord-016652-x8t3lf1x 53 21 Kaposi Kaposi NNP cord-016652-x8t3lf1x 53 22 's 's POS cord-016652-x8t3lf1x 53 23 sarcoma sarcoma NN cord-016652-x8t3lf1x 53 24 associated associate VBD cord-016652-x8t3lf1x 53 25 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 53 26 ( ( -LRB- cord-016652-x8t3lf1x 53 27 KSHV KSHV NNP cord-016652-x8t3lf1x 53 28 ) ) -RRB- cord-016652-x8t3lf1x 53 29 also also RB cord-016652-x8t3lf1x 53 30 dynamically dynamically RB cord-016652-x8t3lf1x 53 31 traffics traffic VBZ cord-016652-x8t3lf1x 53 32 through through IN cord-016652-x8t3lf1x 53 33 the the DT cord-016652-x8t3lf1x 53 34 nucleolus nucleolus NN cord-016652-x8t3lf1x 53 35 ( ( -LRB- cord-016652-x8t3lf1x 53 36 Boyne Boyne NNP cord-016652-x8t3lf1x 53 37 et et NNP cord-016652-x8t3lf1x 53 38 al al NNP cord-016652-x8t3lf1x 53 39 . . NNP cord-016652-x8t3lf1x 53 40 2008b 2008b CD cord-016652-x8t3lf1x 53 41 ) ) -RRB- cord-016652-x8t3lf1x 53 42 . . . cord-016652-x8t3lf1x 54 1 Moreover moreover RB cord-016652-x8t3lf1x 54 2 , , , cord-016652-x8t3lf1x 54 3 on on IN cord-016652-x8t3lf1x 54 4 the the DT cord-016652-x8t3lf1x 54 5 rapid rapid JJ cord-016652-x8t3lf1x 54 6 disorganisation disorganisation NN cord-016652-x8t3lf1x 54 7 of of IN cord-016652-x8t3lf1x 54 8 the the DT cord-016652-x8t3lf1x 54 9 nucleolus nucleolus NN cord-016652-x8t3lf1x 54 10 a a DT cord-016652-x8t3lf1x 54 11 reduction reduction NN cord-016652-x8t3lf1x 54 12 is be VBZ cord-016652-x8t3lf1x 54 13 observed observe VBN cord-016652-x8t3lf1x 54 14 in in IN cord-016652-x8t3lf1x 54 15 virus virus NN cord-016652-x8t3lf1x 54 16 mRNA mRNA NNP cord-016652-x8t3lf1x 54 17 nuclear nuclear JJ cord-016652-x8t3lf1x 54 18 export export NN cord-016652-x8t3lf1x 54 19 ( ( -LRB- cord-016652-x8t3lf1x 54 20 Boyne Boyne NNP cord-016652-x8t3lf1x 54 21 and and CC cord-016652-x8t3lf1x 54 22 Whitehouse Whitehouse NNP cord-016652-x8t3lf1x 54 23 2009 2009 CD cord-016652-x8t3lf1x 54 24 ) ) -RRB- cord-016652-x8t3lf1x 54 25 . . . cord-016652-x8t3lf1x 55 1 The the DT cord-016652-x8t3lf1x 55 2 formation formation NN cord-016652-x8t3lf1x 55 3 of of IN cord-016652-x8t3lf1x 55 4 an an DT cord-016652-x8t3lf1x 55 5 ORF57-mediated orf57-mediated JJ cord-016652-x8t3lf1x 55 6 export export NN cord-016652-x8t3lf1x 55 7 competent competent JJ cord-016652-x8t3lf1x 55 8 ribonucleoprotein ribonucleoprotein NN cord-016652-x8t3lf1x 55 9 particle particle NN cord-016652-x8t3lf1x 55 10 within within IN cord-016652-x8t3lf1x 55 11 the the DT cord-016652-x8t3lf1x 55 12 nucleolus nucleolus NN cord-016652-x8t3lf1x 55 13 may may MD cord-016652-x8t3lf1x 55 14 also also RB cord-016652-x8t3lf1x 55 15 have have VB cord-016652-x8t3lf1x 55 16 implications implication NNS cord-016652-x8t3lf1x 55 17 for for IN cord-016652-x8t3lf1x 55 18 the the DT cord-016652-x8t3lf1x 55 19 translation translation NN cord-016652-x8t3lf1x 55 20 of of IN cord-016652-x8t3lf1x 55 21 viral viral JJ cord-016652-x8t3lf1x 55 22 mRNAs mrnas CD cord-016652-x8t3lf1x 55 23 . . . cord-016652-x8t3lf1x 56 1 For for IN cord-016652-x8t3lf1x 56 2 example example NN cord-016652-x8t3lf1x 56 3 , , , cord-016652-x8t3lf1x 56 4 it -PRON- PRP cord-016652-x8t3lf1x 56 5 has have VBZ cord-016652-x8t3lf1x 56 6 recently recently RB cord-016652-x8t3lf1x 56 7 been be VBN cord-016652-x8t3lf1x 56 8 demonstrated demonstrate VBN cord-016652-x8t3lf1x 56 9 that that IN cord-016652-x8t3lf1x 56 10 the the DT cord-016652-x8t3lf1x 56 11 cellular cellular JJ cord-016652-x8t3lf1x 56 12 nucleo nucleo JJ cord-016652-x8t3lf1x 56 13 - - JJ cord-016652-x8t3lf1x 56 14 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 56 15 shuttle shuttle NN cord-016652-x8t3lf1x 56 16 protein protein NN cord-016652-x8t3lf1x 56 17 , , , cord-016652-x8t3lf1x 56 18 PYM PYM NNP cord-016652-x8t3lf1x 56 19 , , , cord-016652-x8t3lf1x 56 20 which which WDT cord-016652-x8t3lf1x 56 21 is be VBZ cord-016652-x8t3lf1x 56 22 involved involve VBN cord-016652-x8t3lf1x 56 23 in in IN cord-016652-x8t3lf1x 56 24 translation translation NN cord-016652-x8t3lf1x 56 25 enhancement enhancement NN cord-016652-x8t3lf1x 56 26 , , , cord-016652-x8t3lf1x 56 27 is be VBZ cord-016652-x8t3lf1x 56 28 redistributed redistribute VBN cord-016652-x8t3lf1x 56 29 to to IN cord-016652-x8t3lf1x 56 30 the the DT cord-016652-x8t3lf1x 56 31 nucleolus nucleolus NN cord-016652-x8t3lf1x 56 32 in in IN cord-016652-x8t3lf1x 56 33 the the DT cord-016652-x8t3lf1x 56 34 presence presence NN cord-016652-x8t3lf1x 56 35 of of IN cord-016652-x8t3lf1x 56 36 the the DT cord-016652-x8t3lf1x 56 37 KSHV KSHV NNP cord-016652-x8t3lf1x 57 1 ORF57 ORF57 NNP cord-016652-x8t3lf1x 57 2 protein protein NN cord-016652-x8t3lf1x 57 3 ( ( -LRB- cord-016652-x8t3lf1x 57 4 Boyne Boyne NNP cord-016652-x8t3lf1x 57 5 et et NNP cord-016652-x8t3lf1x 57 6 al al NNP cord-016652-x8t3lf1x 57 7 . . NNP cord-016652-x8t3lf1x 57 8 2010 2010 CD cord-016652-x8t3lf1x 57 9 ) ) -RRB- cord-016652-x8t3lf1x 57 10 . . . cord-016652-x8t3lf1x 58 1 This this DT cord-016652-x8t3lf1x 58 2 interaction interaction NN cord-016652-x8t3lf1x 58 3 effectively effectively RB cord-016652-x8t3lf1x 58 4 enhances enhance VBZ cord-016652-x8t3lf1x 58 5 the the DT cord-016652-x8t3lf1x 58 6 translation translation NN cord-016652-x8t3lf1x 58 7 of of IN cord-016652-x8t3lf1x 58 8 the the DT cord-016652-x8t3lf1x 58 9 predominantly predominantly RB cord-016652-x8t3lf1x 58 10 intronless intronless JJ cord-016652-x8t3lf1x 58 11 transcripts transcript NNS cord-016652-x8t3lf1x 58 12 made make VBN cord-016652-x8t3lf1x 58 13 by by IN cord-016652-x8t3lf1x 58 14 KSHV KSHV NNP cord-016652-x8t3lf1x 58 15 , , , cord-016652-x8t3lf1x 58 16 and and CC cord-016652-x8t3lf1x 58 17 draws draw VBZ cord-016652-x8t3lf1x 58 18 parallels parallel NNS cord-016652-x8t3lf1x 58 19 with with IN cord-016652-x8t3lf1x 58 20 potential potential JJ cord-016652-x8t3lf1x 58 21 translation translation NN cord-016652-x8t3lf1x 58 22 enhancement enhancement NN cord-016652-x8t3lf1x 58 23 of of IN cord-016652-x8t3lf1x 58 24 positive positive JJ cord-016652-x8t3lf1x 58 25 strand strand NN cord-016652-x8t3lf1x 58 26 RNA RNA NNP cord-016652-x8t3lf1x 58 27 virus virus NN cord-016652-x8t3lf1x 58 28 genomes genome NNS cord-016652-x8t3lf1x 58 29 through through IN cord-016652-x8t3lf1x 58 30 their -PRON- PRP$ cord-016652-x8t3lf1x 58 31 interaction interaction NN cord-016652-x8t3lf1x 58 32 with with IN cord-016652-x8t3lf1x 58 33 the the DT cord-016652-x8t3lf1x 58 34 nucleolus nucleolus NN cord-016652-x8t3lf1x 58 35 ( ( -LRB- cord-016652-x8t3lf1x 58 36 discussed discuss VBN cord-016652-x8t3lf1x 58 37 later later RB cord-016652-x8t3lf1x 58 38 ) ) -RRB- cord-016652-x8t3lf1x 58 39 . . . cord-016652-x8t3lf1x 59 1 A a DT cord-016652-x8t3lf1x 59 2 second second JJ cord-016652-x8t3lf1x 59 3 area area NN cord-016652-x8t3lf1x 59 4 of of IN cord-016652-x8t3lf1x 59 5 virus virus NN cord-016652-x8t3lf1x 59 6 replication replication NN cord-016652-x8t3lf1x 59 7 where where WRB cord-016652-x8t3lf1x 59 8 nucleolar nucleolar JJ cord-016652-x8t3lf1x 59 9 proteins protein NNS cord-016652-x8t3lf1x 59 10 are be VBP cord-016652-x8t3lf1x 59 11 sequestered sequester VBN cord-016652-x8t3lf1x 59 12 involves involve VBZ cord-016652-x8t3lf1x 59 13 the the DT cord-016652-x8t3lf1x 59 14 replication replication NN cord-016652-x8t3lf1x 59 15 of of IN cord-016652-x8t3lf1x 59 16 the the DT cord-016652-x8t3lf1x 59 17 virus virus NN cord-016652-x8t3lf1x 59 18 DNA dna NN cord-016652-x8t3lf1x 59 19 genome genome NN cord-016652-x8t3lf1x 59 20 . . . cord-016652-x8t3lf1x 60 1 For for IN cord-016652-x8t3lf1x 60 2 example example NN cord-016652-x8t3lf1x 60 3 , , , cord-016652-x8t3lf1x 60 4 we -PRON- PRP cord-016652-x8t3lf1x 60 5 ( ( -LRB- cord-016652-x8t3lf1x 60 6 Matthews Matthews NNP cord-016652-x8t3lf1x 60 7 ) ) -RRB- cord-016652-x8t3lf1x 60 8 and and CC cord-016652-x8t3lf1x 60 9 others other NNS cord-016652-x8t3lf1x 60 10 have have VBP cord-016652-x8t3lf1x 60 11 observed observe VBN cord-016652-x8t3lf1x 60 12 that that IN cord-016652-x8t3lf1x 60 13 nucleolar nucleolar JJ cord-016652-x8t3lf1x 60 14 antigens antigen NNS cord-016652-x8t3lf1x 60 15 upstream upstream RB cord-016652-x8t3lf1x 60 16 binding binding NN cord-016652-x8t3lf1x 60 17 factor factor NN cord-016652-x8t3lf1x 60 18 ( ( -LRB- cord-016652-x8t3lf1x 60 19 UBF UBF NNP cord-016652-x8t3lf1x 60 20 ) ) -RRB- cord-016652-x8t3lf1x 60 21 and and CC cord-016652-x8t3lf1x 60 22 nucleophosmin nucleophosmin NNP cord-016652-x8t3lf1x 60 23 ( ( -LRB- cord-016652-x8t3lf1x 60 24 B23.1 B23.1 NNP cord-016652-x8t3lf1x 60 25 ) ) -RRB- cord-016652-x8t3lf1x 60 26 are be VBP cord-016652-x8t3lf1x 60 27 both both DT cord-016652-x8t3lf1x 60 28 sequestered sequester VBN cord-016652-x8t3lf1x 60 29 into into IN cord-016652-x8t3lf1x 60 30 adenovirus adenovirus NN cord-016652-x8t3lf1x 60 31 DNA dna NN cord-016652-x8t3lf1x 60 32 replication replication NN cord-016652-x8t3lf1x 60 33 centres centre NNS cord-016652-x8t3lf1x 60 34 where where WRB cord-016652-x8t3lf1x 60 35 they -PRON- PRP cord-016652-x8t3lf1x 60 36 promote promote VBP cord-016652-x8t3lf1x 60 37 viral viral JJ cord-016652-x8t3lf1x 60 38 DNA dna NN cord-016652-x8t3lf1x 60 39 replication replication NN cord-016652-x8t3lf1x 60 40 ( ( -LRB- cord-016652-x8t3lf1x 60 41 Hindley Hindley NNP cord-016652-x8t3lf1x 60 42 et et NNP cord-016652-x8t3lf1x 60 43 al al NNP cord-016652-x8t3lf1x 60 44 . . NNP cord-016652-x8t3lf1x 60 45 2007 2007 CD cord-016652-x8t3lf1x 60 46 ; ; : cord-016652-x8t3lf1x 60 47 Lawrence Lawrence NNP cord-016652-x8t3lf1x 60 48 et et NNP cord-016652-x8t3lf1x 60 49 al al NNP cord-016652-x8t3lf1x 60 50 . . . cord-016652-x8t3lf1x 60 51 2006 2006 CD cord-016652-x8t3lf1x 61 1 ; ; : cord-016652-x8t3lf1x 61 2 Okuwaki Okuwaki NNP cord-016652-x8t3lf1x 61 3 et et NNP cord-016652-x8t3lf1x 61 4 al al NNP cord-016652-x8t3lf1x 61 5 . . NNP cord-016652-x8t3lf1x 61 6 2001 2001 CD cord-016652-x8t3lf1x 61 7 ) ) -RRB- cord-016652-x8t3lf1x 61 8 . . . cord-016652-x8t3lf1x 62 1 Similarly similarly RB cord-016652-x8t3lf1x 62 2 , , , cord-016652-x8t3lf1x 62 3 in in IN cord-016652-x8t3lf1x 62 4 HSV-1 hsv-1 NN cord-016652-x8t3lf1x 62 5 infected infect VBN cord-016652-x8t3lf1x 62 6 cells cell NNS cord-016652-x8t3lf1x 62 7 , , , cord-016652-x8t3lf1x 62 8 a a DT cord-016652-x8t3lf1x 62 9 number number NN cord-016652-x8t3lf1x 62 10 of of IN cord-016652-x8t3lf1x 62 11 nucleolar nucleolar JJ cord-016652-x8t3lf1x 62 12 proteins protein NNS cord-016652-x8t3lf1x 62 13 including include VBG cord-016652-x8t3lf1x 62 14 nucleolin nucleolin NNP cord-016652-x8t3lf1x 62 15 and and CC cord-016652-x8t3lf1x 62 16 UBF UBF NNP cord-016652-x8t3lf1x 62 17 are be VBP cord-016652-x8t3lf1x 62 18 recruited recruit VBN cord-016652-x8t3lf1x 62 19 into into IN cord-016652-x8t3lf1x 62 20 viral viral JJ cord-016652-x8t3lf1x 62 21 DNA dna NN cord-016652-x8t3lf1x 62 22 replication replication NN cord-016652-x8t3lf1x 62 23 centres centre NNS cord-016652-x8t3lf1x 62 24 . . . cord-016652-x8t3lf1x 63 1 These these DT cord-016652-x8t3lf1x 63 2 are be VBP cord-016652-x8t3lf1x 63 3 specific specific JJ cord-016652-x8t3lf1x 63 4 sites site NNS cord-016652-x8t3lf1x 63 5 where where WRB cord-016652-x8t3lf1x 63 6 replication replication NN cord-016652-x8t3lf1x 63 7 and and CC cord-016652-x8t3lf1x 63 8 encapsidation encapsidation NN cord-016652-x8t3lf1x 63 9 of of IN cord-016652-x8t3lf1x 63 10 the the DT cord-016652-x8t3lf1x 63 11 HSV-1 HSV-1 NNP cord-016652-x8t3lf1x 63 12 genome genome NN cord-016652-x8t3lf1x 63 13 occurs occur VBZ cord-016652-x8t3lf1x 63 14 . . . cord-016652-x8t3lf1x 64 1 Evidence evidence NN cord-016652-x8t3lf1x 64 2 suggests suggest VBZ cord-016652-x8t3lf1x 64 3 that that IN cord-016652-x8t3lf1x 64 4 sequestration sequestration NN cord-016652-x8t3lf1x 64 5 of of IN cord-016652-x8t3lf1x 64 6 UBF UBF NNP cord-016652-x8t3lf1x 64 7 is be VBZ cord-016652-x8t3lf1x 64 8 essential essential JJ cord-016652-x8t3lf1x 64 9 for for IN cord-016652-x8t3lf1x 64 10 viral viral JJ cord-016652-x8t3lf1x 64 11 DNA dna NN cord-016652-x8t3lf1x 64 12 replication replication NN cord-016652-x8t3lf1x 64 13 as as IN cord-016652-x8t3lf1x 64 14 overexpression overexpression NN cord-016652-x8t3lf1x 64 15 of of IN cord-016652-x8t3lf1x 64 16 tagged tagged JJ cord-016652-x8t3lf1x 64 17 version version NN cord-016652-x8t3lf1x 64 18 of of IN cord-016652-x8t3lf1x 64 19 UBF UBF NNP cord-016652-x8t3lf1x 64 20 acts act NNS cord-016652-x8t3lf1x 64 21 in in IN cord-016652-x8t3lf1x 64 22 a a DT cord-016652-x8t3lf1x 64 23 dominant dominant JJ cord-016652-x8t3lf1x 64 24 - - HYPH cord-016652-x8t3lf1x 64 25 negative negative JJ cord-016652-x8t3lf1x 64 26 manner manner NN cord-016652-x8t3lf1x 64 27 inhibiting inhibit VBG cord-016652-x8t3lf1x 64 28 virus virus NN cord-016652-x8t3lf1x 64 29 DNA dna NN cord-016652-x8t3lf1x 64 30 replication replication NN cord-016652-x8t3lf1x 64 31 ( ( -LRB- cord-016652-x8t3lf1x 64 32 Stow Stow NNP cord-016652-x8t3lf1x 64 33 et et FW cord-016652-x8t3lf1x 64 34 al al NNP cord-016652-x8t3lf1x 64 35 . . . cord-016652-x8t3lf1x 64 36 2009 2009 CD cord-016652-x8t3lf1x 64 37 ) ) -RRB- cord-016652-x8t3lf1x 64 38 . . . cord-016652-x8t3lf1x 65 1 Moreover moreover RB cord-016652-x8t3lf1x 65 2 , , , cord-016652-x8t3lf1x 65 3 depletion depletion NN cord-016652-x8t3lf1x 65 4 of of IN cord-016652-x8t3lf1x 65 5 nucleolin nucleolin NN cord-016652-x8t3lf1x 65 6 results result NNS cord-016652-x8t3lf1x 65 7 in in IN cord-016652-x8t3lf1x 65 8 reduced reduce VBN cord-016652-x8t3lf1x 65 9 virus virus NN cord-016652-x8t3lf1x 65 10 gene gene NN cord-016652-x8t3lf1x 65 11 expression expression NN cord-016652-x8t3lf1x 65 12 and and CC cord-016652-x8t3lf1x 65 13 infectious infectious JJ cord-016652-x8t3lf1x 65 14 virion virion NN cord-016652-x8t3lf1x 65 15 production production NN cord-016652-x8t3lf1x 65 16 ( ( -LRB- cord-016652-x8t3lf1x 65 17 Calle Calle NNP cord-016652-x8t3lf1x 65 18 et et NNP cord-016652-x8t3lf1x 65 19 al al NNP cord-016652-x8t3lf1x 65 20 . . NNP cord-016652-x8t3lf1x 65 21 2008 2008 CD cord-016652-x8t3lf1x 65 22 ; ; : cord-016652-x8t3lf1x 65 23 Sagou Sagou NNP cord-016652-x8t3lf1x 65 24 et et NNP cord-016652-x8t3lf1x 65 25 al al NNP cord-016652-x8t3lf1x 65 26 . . NNP cord-016652-x8t3lf1x 65 27 2010 2010 CD cord-016652-x8t3lf1x 65 28 ) ) -RRB- cord-016652-x8t3lf1x 65 29 . . . cord-016652-x8t3lf1x 66 1 In in IN cord-016652-x8t3lf1x 66 2 addition addition NN cord-016652-x8t3lf1x 66 3 to to IN cord-016652-x8t3lf1x 66 4 enhancing enhance VBG cord-016652-x8t3lf1x 66 5 virus virus NN cord-016652-x8t3lf1x 66 6 replication replication NN cord-016652-x8t3lf1x 66 7 , , , cord-016652-x8t3lf1x 66 8 nucleolar nucleolar JJ cord-016652-x8t3lf1x 66 9 proteins protein NNS cord-016652-x8t3lf1x 66 10 are be VBP cord-016652-x8t3lf1x 66 11 redistributed redistribute VBN cord-016652-x8t3lf1x 66 12 to to TO cord-016652-x8t3lf1x 66 13 alter alter VB cord-016652-x8t3lf1x 66 14 cellular cellular JJ cord-016652-x8t3lf1x 66 15 pathways pathway NNS cord-016652-x8t3lf1x 66 16 during during IN cord-016652-x8t3lf1x 66 17 infection infection NN cord-016652-x8t3lf1x 66 18 . . . cord-016652-x8t3lf1x 67 1 For for IN cord-016652-x8t3lf1x 67 2 example example NN cord-016652-x8t3lf1x 67 3 , , , cord-016652-x8t3lf1x 67 4 the the DT cord-016652-x8t3lf1x 67 5 nucleolar nucleolar NN cord-016652-x8t3lf1x 67 6 targeted target VBN cord-016652-x8t3lf1x 68 1 HSV-1 HSV-1 NNP cord-016652-x8t3lf1x 68 2 US11 US11 NNP cord-016652-x8t3lf1x 68 3 protein protein NN cord-016652-x8t3lf1x 68 4 has have VBZ cord-016652-x8t3lf1x 68 5 been be VBN cord-016652-x8t3lf1x 68 6 shown show VBN cord-016652-x8t3lf1x 68 7 to to TO cord-016652-x8t3lf1x 68 8 interact interact VB cord-016652-x8t3lf1x 68 9 with with IN cord-016652-x8t3lf1x 68 10 homeodomain homeodomain NN cord-016652-x8t3lf1x 68 11 - - HYPH cord-016652-x8t3lf1x 68 12 interacting interact VBG cord-016652-x8t3lf1x 68 13 protein protein NN cord-016652-x8t3lf1x 68 14 kinase kinase NN cord-016652-x8t3lf1x 68 15 2 2 CD cord-016652-x8t3lf1x 68 16 ( ( -LRB- cord-016652-x8t3lf1x 68 17 HIPK2 HIPK2 NNP cord-016652-x8t3lf1x 68 18 ) ) -RRB- cord-016652-x8t3lf1x 68 19 , , , cord-016652-x8t3lf1x 68 20 which which WDT cord-016652-x8t3lf1x 68 21 plays play VBZ cord-016652-x8t3lf1x 68 22 a a DT cord-016652-x8t3lf1x 68 23 role role NN cord-016652-x8t3lf1x 68 24 in in IN cord-016652-x8t3lf1x 68 25 p53-mediated p53-mediated JJ cord-016652-x8t3lf1x 68 26 cellular cellular JJ cord-016652-x8t3lf1x 68 27 apoptosis apoptosis NN cord-016652-x8t3lf1x 68 28 and and CC cord-016652-x8t3lf1x 68 29 hypoxic hypoxic JJ cord-016652-x8t3lf1x 68 30 response response NN cord-016652-x8t3lf1x 68 31 ( ( -LRB- cord-016652-x8t3lf1x 68 32 Calzado Calzado NNP cord-016652-x8t3lf1x 68 33 et et NNP cord-016652-x8t3lf1x 68 34 al al NNP cord-016652-x8t3lf1x 68 35 . . . cord-016652-x8t3lf1x 68 36 2009 2009 CD cord-016652-x8t3lf1x 68 37 ) ) -RRB- cord-016652-x8t3lf1x 68 38 and and CC cord-016652-x8t3lf1x 68 39 also also RB cord-016652-x8t3lf1x 68 40 participates participate VBZ cord-016652-x8t3lf1x 68 41 in in IN cord-016652-x8t3lf1x 68 42 the the DT cord-016652-x8t3lf1x 68 43 regulation regulation NN cord-016652-x8t3lf1x 68 44 of of IN cord-016652-x8t3lf1x 68 45 the the DT cord-016652-x8t3lf1x 68 46 cell cell NN cord-016652-x8t3lf1x 68 47 cycle cycle NN cord-016652-x8t3lf1x 68 48 ( ( -LRB- cord-016652-x8t3lf1x 68 49 Calzado Calzado NNP cord-016652-x8t3lf1x 68 50 et et NNP cord-016652-x8t3lf1x 68 51 al al NNP cord-016652-x8t3lf1x 68 52 . . NNP cord-016652-x8t3lf1x 68 53 2007 2007 CD cord-016652-x8t3lf1x 68 54 ) ) -RRB- cord-016652-x8t3lf1x 68 55 . . . cord-016652-x8t3lf1x 69 1 This this DT cord-016652-x8t3lf1x 69 2 interaction interaction NN cord-016652-x8t3lf1x 69 3 alters alter VBZ cord-016652-x8t3lf1x 69 4 the the DT cord-016652-x8t3lf1x 69 5 sub sub JJ cord-016652-x8t3lf1x 69 6 - - JJ cord-016652-x8t3lf1x 69 7 cellular cellular JJ cord-016652-x8t3lf1x 69 8 localisation localisation NN cord-016652-x8t3lf1x 69 9 of of IN cord-016652-x8t3lf1x 69 10 HIPK2 HIPK2 NNP cord-016652-x8t3lf1x 69 11 and and CC cord-016652-x8t3lf1x 69 12 protects protect VBZ cord-016652-x8t3lf1x 69 13 against against IN cord-016652-x8t3lf1x 69 14 HIPK2-mediated HIPK2-mediated NNP cord-016652-x8t3lf1x 69 15 cell cell NN cord-016652-x8t3lf1x 69 16 cycle cycle NN cord-016652-x8t3lf1x 69 17 arrest arrest NN cord-016652-x8t3lf1x 69 18 ( ( -LRB- cord-016652-x8t3lf1x 69 19 Giraud Giraud NNP cord-016652-x8t3lf1x 69 20 et et NNP cord-016652-x8t3lf1x 69 21 al al NNP cord-016652-x8t3lf1x 69 22 . . . cord-016652-x8t3lf1x 69 23 2004 2004 CD cord-016652-x8t3lf1x 69 24 ) ) -RRB- cord-016652-x8t3lf1x 69 25 . . . cord-016652-x8t3lf1x 70 1 In in IN cord-016652-x8t3lf1x 70 2 contrast contrast NN cord-016652-x8t3lf1x 70 3 , , , cord-016652-x8t3lf1x 70 4 the the DT cord-016652-x8t3lf1x 70 5 cellular cellular JJ cord-016652-x8t3lf1x 70 6 protein protein NN cord-016652-x8t3lf1x 70 7 , , , cord-016652-x8t3lf1x 70 8 protein protein NN cord-016652-x8t3lf1x 70 9 interacting interact VBG cord-016652-x8t3lf1x 70 10 with with IN cord-016652-x8t3lf1x 70 11 the the DT cord-016652-x8t3lf1x 70 12 carboxyl carboxyl NN cord-016652-x8t3lf1x 70 13 terminus-1 terminus-1 NN cord-016652-x8t3lf1x 70 14 ( ( -LRB- cord-016652-x8t3lf1x 70 15 PICT-1 PICT-1 NNP cord-016652-x8t3lf1x 70 16 ) ) -RRB- cord-016652-x8t3lf1x 70 17 , , , cord-016652-x8t3lf1x 70 18 can can MD cord-016652-x8t3lf1x 70 19 sequester sequester VB cord-016652-x8t3lf1x 70 20 the the DT cord-016652-x8t3lf1x 70 21 virally virally RB cord-016652-x8t3lf1x 70 22 encoded encode VBN cord-016652-x8t3lf1x 70 23 apoptosis apoptosis NN cord-016652-x8t3lf1x 70 24 suppressor suppressor NN cord-016652-x8t3lf1x 70 25 protein protein NN cord-016652-x8t3lf1x 70 26 , , , cord-016652-x8t3lf1x 70 27 KS KS NNP cord-016652-x8t3lf1x 70 28 - - HYPH cord-016652-x8t3lf1x 70 29 Bcl-2 Bcl-2 NNP cord-016652-x8t3lf1x 70 30 protein protein NN cord-016652-x8t3lf1x 70 31 , , , cord-016652-x8t3lf1x 70 32 from from IN cord-016652-x8t3lf1x 70 33 the the DT cord-016652-x8t3lf1x 70 34 mitochondria mitochondrion NNS cord-016652-x8t3lf1x 70 35 into into IN cord-016652-x8t3lf1x 70 36 the the DT cord-016652-x8t3lf1x 70 37 nucleolus nucleolus NN cord-016652-x8t3lf1x 70 38 to to IN cord-016652-x8t3lf1x 70 39 down down RB cord-016652-x8t3lf1x 70 40 - - HYPH cord-016652-x8t3lf1x 70 41 regulate regulate VB cord-016652-x8t3lf1x 70 42 its -PRON- PRP$ cord-016652-x8t3lf1x 70 43 anti anti JJ cord-016652-x8t3lf1x 70 44 - - JJ cord-016652-x8t3lf1x 70 45 apoptotic apoptotic JJ cord-016652-x8t3lf1x 70 46 activity activity NN cord-016652-x8t3lf1x 70 47 ( ( -LRB- cord-016652-x8t3lf1x 70 48 Kalt Kalt NNP cord-016652-x8t3lf1x 70 49 et et NNP cord-016652-x8t3lf1x 70 50 al al NNP cord-016652-x8t3lf1x 70 51 . . NNP cord-016652-x8t3lf1x 70 52 2010 2010 CD cord-016652-x8t3lf1x 70 53 ) ) -RRB- cord-016652-x8t3lf1x 70 54 . . . cord-016652-x8t3lf1x 71 1 This this DT cord-016652-x8t3lf1x 71 2 is be VBZ cord-016652-x8t3lf1x 71 3 a a DT cord-016652-x8t3lf1x 71 4 potential potential JJ cord-016652-x8t3lf1x 71 5 interesting interesting JJ cord-016652-x8t3lf1x 71 6 interplay interplay NN cord-016652-x8t3lf1x 71 7 between between IN cord-016652-x8t3lf1x 71 8 two two CD cord-016652-x8t3lf1x 71 9 sub sub JJ cord-016652-x8t3lf1x 71 10 - - JJ cord-016652-x8t3lf1x 71 11 cellular cellular JJ cord-016652-x8t3lf1x 71 12 structures structure NNS cord-016652-x8t3lf1x 71 13 involved involve VBN cord-016652-x8t3lf1x 71 14 in in IN cord-016652-x8t3lf1x 71 15 the the DT cord-016652-x8t3lf1x 71 16 viral viral JJ cord-016652-x8t3lf1x 71 17 stress stress NN cord-016652-x8t3lf1x 71 18 response response NN cord-016652-x8t3lf1x 71 19 ( ( -LRB- cord-016652-x8t3lf1x 71 20 Olson Olson NNP cord-016652-x8t3lf1x 71 21 2009 2009 CD cord-016652-x8t3lf1x 71 22 ) ) -RRB- cord-016652-x8t3lf1x 71 23 , , , cord-016652-x8t3lf1x 71 24 and and CC cord-016652-x8t3lf1x 71 25 maybe maybe RB cord-016652-x8t3lf1x 71 26 more more RBR cord-016652-x8t3lf1x 71 27 common common JJ cord-016652-x8t3lf1x 71 28 and and CC cord-016652-x8t3lf1x 71 29 widespread widespread JJ cord-016652-x8t3lf1x 71 30 . . . cord-016652-x8t3lf1x 72 1 For for IN cord-016652-x8t3lf1x 72 2 example example NN cord-016652-x8t3lf1x 72 3 , , , cord-016652-x8t3lf1x 72 4 bacterial bacterial JJ cord-016652-x8t3lf1x 72 5 infection infection NN cord-016652-x8t3lf1x 72 6 has have VBZ cord-016652-x8t3lf1x 72 7 been be VBN cord-016652-x8t3lf1x 72 8 shown show VBN cord-016652-x8t3lf1x 72 9 to to TO cord-016652-x8t3lf1x 72 10 disrupt disrupt VB cord-016652-x8t3lf1x 72 11 the the DT cord-016652-x8t3lf1x 72 12 nucleolus nucleolus NN cord-016652-x8t3lf1x 72 13 through through IN cord-016652-x8t3lf1x 72 14 regulating regulate VBG cord-016652-x8t3lf1x 72 15 mitochondrial mitochondrial JJ cord-016652-x8t3lf1x 72 16 dysfunction dysfunction NN cord-016652-x8t3lf1x 72 17 ( ( -LRB- cord-016652-x8t3lf1x 72 18 Dean Dean NNP cord-016652-x8t3lf1x 72 19 et et NNP cord-016652-x8t3lf1x 72 20 al al NNP cord-016652-x8t3lf1x 72 21 . . NNP cord-016652-x8t3lf1x 72 22 2010 2010 CD cord-016652-x8t3lf1x 72 23 ) ) -RRB- cord-016652-x8t3lf1x 72 24 . . . cord-016652-x8t3lf1x 73 1 Although although IN cord-016652-x8t3lf1x 73 2 many many JJ cord-016652-x8t3lf1x 73 3 RNA RNA NNP cord-016652-x8t3lf1x 73 4 virus virus NN cord-016652-x8t3lf1x 73 5 proteins protein NNS cord-016652-x8t3lf1x 73 6 have have VBP cord-016652-x8t3lf1x 73 7 been be VBN cord-016652-x8t3lf1x 73 8 shown show VBN cord-016652-x8t3lf1x 73 9 to to TO cord-016652-x8t3lf1x 73 10 localise localise VB cord-016652-x8t3lf1x 73 11 to to IN cord-016652-x8t3lf1x 73 12 the the DT cord-016652-x8t3lf1x 73 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 73 14 , , , cord-016652-x8t3lf1x 73 15 most most JJS cord-016652-x8t3lf1x 73 16 attention attention NN cord-016652-x8t3lf1x 73 17 has have VBZ cord-016652-x8t3lf1x 73 18 focused focus VBN cord-016652-x8t3lf1x 73 19 on on IN cord-016652-x8t3lf1x 73 20 viral viral JJ cord-016652-x8t3lf1x 73 21 capsid capsid NN cord-016652-x8t3lf1x 73 22 proteins protein NNS cord-016652-x8t3lf1x 73 23 . . . cord-016652-x8t3lf1x 74 1 These these DT cord-016652-x8t3lf1x 74 2 are be VBP cord-016652-x8t3lf1x 74 3 proteins protein NNS cord-016652-x8t3lf1x 74 4 that that WDT cord-016652-x8t3lf1x 74 5 associate associate VBP cord-016652-x8t3lf1x 74 6 with with IN cord-016652-x8t3lf1x 74 7 the the DT cord-016652-x8t3lf1x 74 8 viral viral JJ cord-016652-x8t3lf1x 74 9 genome genome NN cord-016652-x8t3lf1x 74 10 for for IN cord-016652-x8t3lf1x 74 11 encapsidation encapsidation NN cord-016652-x8t3lf1x 74 12 and and CC cord-016652-x8t3lf1x 74 13 assembly assembly NN cord-016652-x8t3lf1x 74 14 of of IN cord-016652-x8t3lf1x 74 15 new new JJ cord-016652-x8t3lf1x 74 16 virus virus NN cord-016652-x8t3lf1x 74 17 particles particle NNS cord-016652-x8t3lf1x 74 18 . . . cord-016652-x8t3lf1x 75 1 These these DT cord-016652-x8t3lf1x 75 2 proteins protein NNS cord-016652-x8t3lf1x 75 3 may may MD cord-016652-x8t3lf1x 75 4 also also RB cord-016652-x8t3lf1x 75 5 modulate modulate VB cord-016652-x8t3lf1x 75 6 replication replication NN cord-016652-x8t3lf1x 75 7 ( ( -LRB- cord-016652-x8t3lf1x 75 8 and and CC cord-016652-x8t3lf1x 75 9 transcription transcription NN cord-016652-x8t3lf1x 75 10 , , , cord-016652-x8t3lf1x 75 11 where where WRB cord-016652-x8t3lf1x 75 12 appropriate appropriate JJ cord-016652-x8t3lf1x 75 13 ) ) -RRB- cord-016652-x8t3lf1x 75 14 of of IN cord-016652-x8t3lf1x 75 15 the the DT cord-016652-x8t3lf1x 75 16 viral viral JJ cord-016652-x8t3lf1x 75 17 genome genome NN cord-016652-x8t3lf1x 75 18 . . . cord-016652-x8t3lf1x 76 1 Increasingly increasingly RB cord-016652-x8t3lf1x 76 2 , , , cord-016652-x8t3lf1x 76 3 capsid capsid NN cord-016652-x8t3lf1x 76 4 proteins protein NNS cord-016652-x8t3lf1x 76 5 have have VBP cord-016652-x8t3lf1x 76 6 also also RB cord-016652-x8t3lf1x 76 7 been be VBN cord-016652-x8t3lf1x 76 8 shown show VBN cord-016652-x8t3lf1x 76 9 to to TO cord-016652-x8t3lf1x 76 10 have have VB cord-016652-x8t3lf1x 76 11 a a DT cord-016652-x8t3lf1x 76 12 number number NN cord-016652-x8t3lf1x 76 13 of of IN cord-016652-x8t3lf1x 76 14 roles role NNS cord-016652-x8t3lf1x 76 15 in in IN cord-016652-x8t3lf1x 76 16 modulating modulate VBG cord-016652-x8t3lf1x 76 17 host host NN cord-016652-x8t3lf1x 76 18 cell cell NN cord-016652-x8t3lf1x 76 19 signalling signal VBG cord-016652-x8t3lf1x 76 20 pathways pathway NNS cord-016652-x8t3lf1x 76 21 and and CC cord-016652-x8t3lf1x 76 22 functions function NNS cord-016652-x8t3lf1x 76 23 . . . cord-016652-x8t3lf1x 77 1 These these DT cord-016652-x8t3lf1x 77 2 capsid capsid NN cord-016652-x8t3lf1x 77 3 proteins protein NNS cord-016652-x8t3lf1x 77 4 are be VBP cord-016652-x8t3lf1x 77 5 referred refer VBN cord-016652-x8t3lf1x 77 6 to to IN cord-016652-x8t3lf1x 77 7 as as IN cord-016652-x8t3lf1x 77 8 capsid capsid NN cord-016652-x8t3lf1x 77 9 , , , cord-016652-x8t3lf1x 77 10 nucleoproteins nucleoprotein NNS cord-016652-x8t3lf1x 77 11 or or CC cord-016652-x8t3lf1x 77 12 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 77 13 proteins protein NNS cord-016652-x8t3lf1x 77 14 , , , cord-016652-x8t3lf1x 77 15 depending depend VBG cord-016652-x8t3lf1x 77 16 on on IN cord-016652-x8t3lf1x 77 17 the the DT cord-016652-x8t3lf1x 77 18 virus virus NN cord-016652-x8t3lf1x 77 19 . . . cord-016652-x8t3lf1x 78 1 In in IN cord-016652-x8t3lf1x 78 2 many many JJ cord-016652-x8t3lf1x 78 3 cases case NNS cord-016652-x8t3lf1x 78 4 , , , cord-016652-x8t3lf1x 78 5 they -PRON- PRP cord-016652-x8t3lf1x 78 6 are be VBP cord-016652-x8t3lf1x 78 7 phosphorylated phosphorylate VBN cord-016652-x8t3lf1x 78 8 ( ( -LRB- cord-016652-x8t3lf1x 78 9 Chen Chen NNP cord-016652-x8t3lf1x 78 10 et et NNP cord-016652-x8t3lf1x 78 11 al al NNP cord-016652-x8t3lf1x 78 12 . . NNP cord-016652-x8t3lf1x 78 13 2005 2005 CD cord-016652-x8t3lf1x 78 14 ) ) -RRB- cord-016652-x8t3lf1x 78 15 , , , cord-016652-x8t3lf1x 78 16 which which WDT cord-016652-x8t3lf1x 78 17 can can MD cord-016652-x8t3lf1x 78 18 modulate modulate VB cord-016652-x8t3lf1x 78 19 activity activity NN cord-016652-x8t3lf1x 79 1 ( ( -LRB- cord-016652-x8t3lf1x 79 2 Spencer Spencer NNP cord-016652-x8t3lf1x 79 3 et et NNP cord-016652-x8t3lf1x 79 4 al al NNP cord-016652-x8t3lf1x 79 5 . . NNP cord-016652-x8t3lf1x 79 6 2008 2008 CD cord-016652-x8t3lf1x 79 7 ) ) -RRB- cord-016652-x8t3lf1x 79 8 . . . cord-016652-x8t3lf1x 80 1 Many many JJ cord-016652-x8t3lf1x 80 2 examples example NNS cord-016652-x8t3lf1x 80 3 of of IN cord-016652-x8t3lf1x 80 4 these these DT cord-016652-x8t3lf1x 80 5 proteins protein NNS cord-016652-x8t3lf1x 80 6 have have VBP cord-016652-x8t3lf1x 80 7 been be VBN cord-016652-x8t3lf1x 80 8 shown show VBN cord-016652-x8t3lf1x 80 9 to to TO cord-016652-x8t3lf1x 80 10 localise localise VB cord-016652-x8t3lf1x 80 11 to to IN cord-016652-x8t3lf1x 80 12 the the DT cord-016652-x8t3lf1x 80 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 80 14 both both CC cord-016652-x8t3lf1x 80 15 when when WRB cord-016652-x8t3lf1x 80 16 over over RB cord-016652-x8t3lf1x 80 17 - - HYPH cord-016652-x8t3lf1x 80 18 expressed express VBN cord-016652-x8t3lf1x 80 19 and and CC cord-016652-x8t3lf1x 80 20 also also RB cord-016652-x8t3lf1x 80 21 in in IN cord-016652-x8t3lf1x 80 22 infected infected JJ cord-016652-x8t3lf1x 80 23 cells cell NNS cord-016652-x8t3lf1x 80 24 . . . cord-016652-x8t3lf1x 81 1 These these DT cord-016652-x8t3lf1x 81 2 include include VBP cord-016652-x8t3lf1x 81 3 proteins protein NNS cord-016652-x8t3lf1x 81 4 from from IN cord-016652-x8t3lf1x 81 5 positive positive JJ cord-016652-x8t3lf1x 81 6 - - HYPH cord-016652-x8t3lf1x 81 7 strand strand NN cord-016652-x8t3lf1x 81 8 animal animal NN cord-016652-x8t3lf1x 81 9 and and CC cord-016652-x8t3lf1x 81 10 plant plant NN cord-016652-x8t3lf1x 81 11 RNA RNA NNP cord-016652-x8t3lf1x 81 12 viruses virus NNS cord-016652-x8t3lf1x 81 13 , , , cord-016652-x8t3lf1x 81 14 including include VBG cord-016652-x8t3lf1x 81 15 the the DT cord-016652-x8t3lf1x 81 16 coronavirus coronavirus NN cord-016652-x8t3lf1x 81 17 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 81 18 protein protein NN cord-016652-x8t3lf1x 81 19 ( ( -LRB- cord-016652-x8t3lf1x 81 20 Chen Chen NNP cord-016652-x8t3lf1x 81 21 et et NNP cord-016652-x8t3lf1x 81 22 al al NNP cord-016652-x8t3lf1x 81 23 . . . cord-016652-x8t3lf1x 81 24 2002 2002 CD cord-016652-x8t3lf1x 81 25 ; ; : cord-016652-x8t3lf1x 81 26 Hiscox Hiscox NNP cord-016652-x8t3lf1x 81 27 et et NNP cord-016652-x8t3lf1x 81 28 al al NNP cord-016652-x8t3lf1x 81 29 . . NNP cord-016652-x8t3lf1x 81 30 2001 2001 CD cord-016652-x8t3lf1x 81 31 ; ; : cord-016652-x8t3lf1x 81 32 Wurm Wurm NNP cord-016652-x8t3lf1x 81 33 et et NNP cord-016652-x8t3lf1x 81 34 al al NNP cord-016652-x8t3lf1x 81 35 . . NNP cord-016652-x8t3lf1x 81 36 2001 2001 CD cord-016652-x8t3lf1x 81 37 ) ) -RRB- cord-016652-x8t3lf1x 81 38 , , , cord-016652-x8t3lf1x 81 39 the the DT cord-016652-x8t3lf1x 81 40 arterivirus arterivirus NNP cord-016652-x8t3lf1x 81 41 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 81 42 protein protein NNP cord-016652-x8t3lf1x 81 43 ( ( -LRB- cord-016652-x8t3lf1x 81 44 Rowland Rowland NNP cord-016652-x8t3lf1x 81 45 et et NNP cord-016652-x8t3lf1x 81 46 al al NNP cord-016652-x8t3lf1x 81 47 . . . cord-016652-x8t3lf1x 81 48 1999 1999 CD cord-016652-x8t3lf1x 81 49 ) ) -RRB- cord-016652-x8t3lf1x 81 50 , , , cord-016652-x8t3lf1x 81 51 the the DT cord-016652-x8t3lf1x 81 52 alphavirus alphavirus NNP cord-016652-x8t3lf1x 81 53 capsid capsid NN cord-016652-x8t3lf1x 81 54 protein protein NN cord-016652-x8t3lf1x 81 55 ( ( -LRB- cord-016652-x8t3lf1x 81 56 Jakob Jakob NNP cord-016652-x8t3lf1x 81 57 1994 1994 CD cord-016652-x8t3lf1x 81 58 ) ) -RRB- cord-016652-x8t3lf1x 81 59 and and CC cord-016652-x8t3lf1x 81 60 non non JJ cord-016652-x8t3lf1x 81 61 - - JJ cord-016652-x8t3lf1x 81 62 structural structural JJ cord-016652-x8t3lf1x 81 63 protein protein NN cord-016652-x8t3lf1x 82 1 nsP2 nsP2 . cord-016652-x8t3lf1x 83 1 ( ( -LRB- cord-016652-x8t3lf1x 83 2 Rikkonen Rikkonen NNP cord-016652-x8t3lf1x 83 3 et et FW cord-016652-x8t3lf1x 83 4 al al NNP cord-016652-x8t3lf1x 83 5 . . . cord-016652-x8t3lf1x 83 6 1992 1992 CD cord-016652-x8t3lf1x 84 1 ( ( -LRB- cord-016652-x8t3lf1x 84 2 Rikkonen Rikkonen NNP cord-016652-x8t3lf1x 84 3 et et FW cord-016652-x8t3lf1x 84 4 al al NNP cord-016652-x8t3lf1x 84 5 . . . cord-016652-x8t3lf1x 85 1 , , , cord-016652-x8t3lf1x 85 2 1994 1994 CD cord-016652-x8t3lf1x 85 3 and and CC cord-016652-x8t3lf1x 85 4 the the DT cord-016652-x8t3lf1x 85 5 umbravirus umbravirus NNP cord-016652-x8t3lf1x 85 6 ORF3 ORF3 NNP cord-016652-x8t3lf1x 85 7 protein protein NN cord-016652-x8t3lf1x 85 8 ( ( -LRB- cord-016652-x8t3lf1x 85 9 Ryabov Ryabov NNP cord-016652-x8t3lf1x 85 10 et et FW cord-016652-x8t3lf1x 85 11 al al NNP cord-016652-x8t3lf1x 85 12 . . . cord-016652-x8t3lf1x 85 13 2004 2004 CD cord-016652-x8t3lf1x 85 14 ) ) -RRB- cord-016652-x8t3lf1x 85 15 . . . cord-016652-x8t3lf1x 86 1 Capsid capsid NN cord-016652-x8t3lf1x 86 2 proteins protein NNS cord-016652-x8t3lf1x 86 3 from from IN cord-016652-x8t3lf1x 86 4 negative negative JJ cord-016652-x8t3lf1x 86 5 - - HYPH cord-016652-x8t3lf1x 86 6 strand strand NN cord-016652-x8t3lf1x 86 7 RNA RNA NNP cord-016652-x8t3lf1x 86 8 viruses virus NNS cord-016652-x8t3lf1x 86 9 also also RB cord-016652-x8t3lf1x 86 10 localise localise VBP cord-016652-x8t3lf1x 86 11 to to IN cord-016652-x8t3lf1x 86 12 the the DT cord-016652-x8t3lf1x 86 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 86 14 . . . cord-016652-x8t3lf1x 87 1 These these DT cord-016652-x8t3lf1x 87 2 have have VBP cord-016652-x8t3lf1x 87 3 strain strain NN cord-016652-x8t3lf1x 87 4 dependent dependent JJ cord-016652-x8t3lf1x 87 5 localisation localisation NN cord-016652-x8t3lf1x 87 6 of of IN cord-016652-x8t3lf1x 87 7 a a DT cord-016652-x8t3lf1x 87 8 number number NN cord-016652-x8t3lf1x 87 9 of of IN cord-016652-x8t3lf1x 87 10 different different JJ cord-016652-x8t3lf1x 87 11 influenza influenza NN cord-016652-x8t3lf1x 87 12 virus virus NN cord-016652-x8t3lf1x 87 13 proteins protein NNS cord-016652-x8t3lf1x 87 14 ( ( -LRB- cord-016652-x8t3lf1x 87 15 Emmott Emmott NNP cord-016652-x8t3lf1x 87 16 et et NNP cord-016652-x8t3lf1x 87 17 al al NNP cord-016652-x8t3lf1x 87 18 . . NNP cord-016652-x8t3lf1x 87 19 2010c 2010c CD cord-016652-x8t3lf1x 87 20 ; ; : cord-016652-x8t3lf1x 87 21 Han Han NNP cord-016652-x8t3lf1x 87 22 et et NNP cord-016652-x8t3lf1x 87 23 al al NNP cord-016652-x8t3lf1x 87 24 . . . cord-016652-x8t3lf1x 87 25 2010 2010 CD cord-016652-x8t3lf1x 88 1 ; ; : cord-016652-x8t3lf1x 88 2 Melen Melen NNP cord-016652-x8t3lf1x 88 3 et et NNP cord-016652-x8t3lf1x 88 4 al al NNP cord-016652-x8t3lf1x 88 5 . . . cord-016652-x8t3lf1x 89 1 2007 2007 CD cord-016652-x8t3lf1x 89 2 ; ; : cord-016652-x8t3lf1x 89 3 Volmer Volmer NNP cord-016652-x8t3lf1x 89 4 et et NNP cord-016652-x8t3lf1x 89 5 al al NNP cord-016652-x8t3lf1x 89 6 . . NNP cord-016652-x8t3lf1x 89 7 2010 2010 CD cord-016652-x8t3lf1x 89 8 ) ) -RRB- cord-016652-x8t3lf1x 89 9 . . . cord-016652-x8t3lf1x 90 1 For for IN cord-016652-x8t3lf1x 90 2 many many JJ cord-016652-x8t3lf1x 90 3 years year NNS cord-016652-x8t3lf1x 90 4 this this DT cord-016652-x8t3lf1x 90 5 has have VBZ cord-016652-x8t3lf1x 90 6 followed follow VBN cord-016652-x8t3lf1x 90 7 a a DT cord-016652-x8t3lf1x 90 8 phenomenological phenomenological JJ cord-016652-x8t3lf1x 90 9 pattern pattern NN cord-016652-x8t3lf1x 90 10 and and CC cord-016652-x8t3lf1x 90 11 viral viral JJ cord-016652-x8t3lf1x 90 12 capsid capsid NN cord-016652-x8t3lf1x 90 13 and and CC cord-016652-x8t3lf1x 90 14 RNA rna NN cord-016652-x8t3lf1x 90 15 - - HYPH cord-016652-x8t3lf1x 90 16 binding bind VBG cord-016652-x8t3lf1x 90 17 proteins protein NNS cord-016652-x8t3lf1x 90 18 might may MD cord-016652-x8t3lf1x 90 19 simply simply RB cord-016652-x8t3lf1x 90 20 localise localise VB cord-016652-x8t3lf1x 90 21 to to IN cord-016652-x8t3lf1x 90 22 the the DT cord-016652-x8t3lf1x 90 23 nucleolus nucleolus NN cord-016652-x8t3lf1x 90 24 because because IN cord-016652-x8t3lf1x 90 25 they -PRON- PRP cord-016652-x8t3lf1x 90 26 diffuse diffuse VBP cord-016652-x8t3lf1x 90 27 through through IN cord-016652-x8t3lf1x 90 28 the the DT cord-016652-x8t3lf1x 90 29 nuclear nuclear JJ cord-016652-x8t3lf1x 90 30 pore pore NN cord-016652-x8t3lf1x 90 31 complex complex NN cord-016652-x8t3lf1x 90 32 and and CC cord-016652-x8t3lf1x 90 33 associate associate JJ cord-016652-x8t3lf1x 90 34 with with IN cord-016652-x8t3lf1x 90 35 compartments compartment NNS cord-016652-x8t3lf1x 90 36 in in IN cord-016652-x8t3lf1x 90 37 the the DT cord-016652-x8t3lf1x 90 38 nucleus nucleus NN cord-016652-x8t3lf1x 90 39 that that WDT cord-016652-x8t3lf1x 90 40 have have VBP cord-016652-x8t3lf1x 90 41 high high JJ cord-016652-x8t3lf1x 90 42 RNA RNA NNP cord-016652-x8t3lf1x 90 43 contents content NNS cord-016652-x8t3lf1x 90 44 -the -the DT cord-016652-x8t3lf1x 90 45 nucleolus nucleolus NN cord-016652-x8t3lf1x 90 46 in in IN cord-016652-x8t3lf1x 90 47 particular particular JJ cord-016652-x8t3lf1x 90 48 because because IN cord-016652-x8t3lf1x 90 49 it -PRON- PRP cord-016652-x8t3lf1x 90 50 is be VBZ cord-016652-x8t3lf1x 90 51 transcriptionally transcriptionally RB cord-016652-x8t3lf1x 90 52 active active JJ cord-016652-x8t3lf1x 90 53 . . . cord-016652-x8t3lf1x 91 1 In in IN cord-016652-x8t3lf1x 91 2 this this DT cord-016652-x8t3lf1x 91 3 case case NN cord-016652-x8t3lf1x 91 4 , , , cord-016652-x8t3lf1x 91 5 sub sub JJ cord-016652-x8t3lf1x 91 6 - - JJ cord-016652-x8t3lf1x 91 7 cellular cellular JJ cord-016652-x8t3lf1x 91 8 localisation localisation NN cord-016652-x8t3lf1x 91 9 to to IN cord-016652-x8t3lf1x 91 10 the the DT cord-016652-x8t3lf1x 91 11 nucleolus nucleolus NN cord-016652-x8t3lf1x 91 12 would would MD cord-016652-x8t3lf1x 91 13 have have VB cord-016652-x8t3lf1x 91 14 no no DT cord-016652-x8t3lf1x 91 15 physiological physiological JJ cord-016652-x8t3lf1x 91 16 consequence consequence NN cord-016652-x8t3lf1x 91 17 for for IN cord-016652-x8t3lf1x 91 18 the the DT cord-016652-x8t3lf1x 91 19 virus virus NN cord-016652-x8t3lf1x 91 20 or or CC cord-016652-x8t3lf1x 91 21 the the DT cord-016652-x8t3lf1x 91 22 cell cell NN cord-016652-x8t3lf1x 91 23 . . . cord-016652-x8t3lf1x 92 1 However however RB cord-016652-x8t3lf1x 92 2 , , , cord-016652-x8t3lf1x 92 3 RNA RNA NNP cord-016652-x8t3lf1x 92 4 virus virus NN cord-016652-x8t3lf1x 92 5 replication replication NN cord-016652-x8t3lf1x 92 6 is be VBZ cord-016652-x8t3lf1x 92 7 error error NN cord-016652-x8t3lf1x 92 8 prone prone JJ cord-016652-x8t3lf1x 92 9 and and CC cord-016652-x8t3lf1x 92 10 selection selection NN cord-016652-x8t3lf1x 92 11 pressure pressure NN cord-016652-x8t3lf1x 92 12 might may MD cord-016652-x8t3lf1x 92 13 apply apply VB cord-016652-x8t3lf1x 92 14 to to IN cord-016652-x8t3lf1x 92 15 such such PDT cord-016652-x8t3lf1x 92 16 a a DT cord-016652-x8t3lf1x 92 17 fortuitous fortuitous JJ cord-016652-x8t3lf1x 92 18 localisation localisation NN cord-016652-x8t3lf1x 92 19 ( ( -LRB- cord-016652-x8t3lf1x 92 20 given give VBN cord-016652-x8t3lf1x 92 21 the the DT cord-016652-x8t3lf1x 92 22 ~4,500 ~4,500 CD cord-016652-x8t3lf1x 92 23 + + SYM cord-016652-x8t3lf1x 92 24 nucleolar nucleolar JJ cord-016652-x8t3lf1x 92 25 proteins protein NNS cord-016652-x8t3lf1x 92 26 and and CC cord-016652-x8t3lf1x 92 27 their -PRON- PRP$ cord-016652-x8t3lf1x 92 28 diverse diverse JJ cord-016652-x8t3lf1x 92 29 roles role NNS cord-016652-x8t3lf1x 92 30 ( ( -LRB- cord-016652-x8t3lf1x 92 31 Ahmad Ahmad NNP cord-016652-x8t3lf1x 92 32 et et NNP cord-016652-x8t3lf1x 92 33 al al NNP cord-016652-x8t3lf1x 92 34 . . . cord-016652-x8t3lf1x 92 35 2009 2009 CD cord-016652-x8t3lf1x 92 36 ) ) -RRB- cord-016652-x8t3lf1x 92 37 ) ) -RRB- cord-016652-x8t3lf1x 92 38 , , , cord-016652-x8t3lf1x 92 39 with with IN cord-016652-x8t3lf1x 92 40 the the DT cord-016652-x8t3lf1x 92 41 concomitant concomitant JJ cord-016652-x8t3lf1x 92 42 effect effect NN cord-016652-x8t3lf1x 92 43 that that IN cord-016652-x8t3lf1x 92 44 the the DT cord-016652-x8t3lf1x 92 45 virus virus NN cord-016652-x8t3lf1x 92 46 could could MD cord-016652-x8t3lf1x 92 47 select select VB cord-016652-x8t3lf1x 92 48 for for IN cord-016652-x8t3lf1x 92 49 changes change NNS cord-016652-x8t3lf1x 92 50 that that WDT cord-016652-x8t3lf1x 92 51 ultimately ultimately RB cord-016652-x8t3lf1x 92 52 disrupt disrupt VBP cord-016652-x8t3lf1x 92 53 nucleolar nucleolar JJ cord-016652-x8t3lf1x 92 54 function function NN cord-016652-x8t3lf1x 92 55 and/or and/or CC cord-016652-x8t3lf1x 92 56 recruit recruit VB cord-016652-x8t3lf1x 92 57 nucleolar nucleolar JJ cord-016652-x8t3lf1x 92 58 proteins protein NNS cord-016652-x8t3lf1x 92 59 to to TO cord-016652-x8t3lf1x 92 60 aid aid VB cord-016652-x8t3lf1x 92 61 virus virus NN cord-016652-x8t3lf1x 92 62 replication replication NN cord-016652-x8t3lf1x 92 63 . . . cord-016652-x8t3lf1x 93 1 There there EX cord-016652-x8t3lf1x 93 2 is be VBZ cord-016652-x8t3lf1x 93 3 a a DT cord-016652-x8t3lf1x 93 4 potential potential JJ cord-016652-x8t3lf1x 93 5 correlation correlation NN cord-016652-x8t3lf1x 93 6 between between IN cord-016652-x8t3lf1x 93 7 the the DT cord-016652-x8t3lf1x 93 8 nucleolar nucleolar JJ cord-016652-x8t3lf1x 93 9 localisation localisation NN cord-016652-x8t3lf1x 93 10 of of IN cord-016652-x8t3lf1x 93 11 a a DT cord-016652-x8t3lf1x 93 12 viral viral JJ cord-016652-x8t3lf1x 93 13 protein protein NN cord-016652-x8t3lf1x 93 14 and and CC cord-016652-x8t3lf1x 93 15 the the DT cord-016652-x8t3lf1x 93 16 loss loss NN cord-016652-x8t3lf1x 93 17 of of IN cord-016652-x8t3lf1x 93 18 an an DT cord-016652-x8t3lf1x 93 19 essential essential JJ cord-016652-x8t3lf1x 93 20 nucleolar nucleolar JJ cord-016652-x8t3lf1x 93 21 function function NN cord-016652-x8t3lf1x 93 22 . . . cord-016652-x8t3lf1x 94 1 The the DT cord-016652-x8t3lf1x 94 2 molecular molecular JJ cord-016652-x8t3lf1x 94 3 mechanisms mechanism NNS cord-016652-x8t3lf1x 94 4 responsible responsible JJ cord-016652-x8t3lf1x 94 5 for for IN cord-016652-x8t3lf1x 94 6 this this DT cord-016652-x8t3lf1x 94 7 effect effect NN cord-016652-x8t3lf1x 94 8 are be VBP cord-016652-x8t3lf1x 94 9 unknown unknown JJ cord-016652-x8t3lf1x 94 10 , , , cord-016652-x8t3lf1x 94 11 but but CC cord-016652-x8t3lf1x 94 12 the the DT cord-016652-x8t3lf1x 94 13 displacement displacement NN cord-016652-x8t3lf1x 94 14 and and CC cord-016652-x8t3lf1x 94 15 re re NN cord-016652-x8t3lf1x 94 16 - - NN cord-016652-x8t3lf1x 94 17 localisation localisation NN cord-016652-x8t3lf1x 94 18 of of IN cord-016652-x8t3lf1x 94 19 nucleolar nucleolar JJ cord-016652-x8t3lf1x 94 20 proteins protein NNS cord-016652-x8t3lf1x 94 21 by by IN cord-016652-x8t3lf1x 94 22 viral viral JJ cord-016652-x8t3lf1x 94 23 proteins protein NNS cord-016652-x8t3lf1x 94 24 could could MD cord-016652-x8t3lf1x 94 25 increase increase VB cord-016652-x8t3lf1x 94 26 or or CC cord-016652-x8t3lf1x 94 27 decrease decrease VB cord-016652-x8t3lf1x 94 28 the the DT cord-016652-x8t3lf1x 94 29 nucleolar nucleolar JJ cord-016652-x8t3lf1x 94 30 , , , cord-016652-x8t3lf1x 94 31 nuclear nuclear JJ cord-016652-x8t3lf1x 94 32 and/or and/or CC cord-016652-x8t3lf1x 94 33 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 94 34 pool pool NN cord-016652-x8t3lf1x 94 35 of of IN cord-016652-x8t3lf1x 94 36 these these DT cord-016652-x8t3lf1x 94 37 proteins protein NNS cord-016652-x8t3lf1x 94 38 . . . cord-016652-x8t3lf1x 95 1 Certainly certainly RB cord-016652-x8t3lf1x 95 2 , , , cord-016652-x8t3lf1x 95 3 the the DT cord-016652-x8t3lf1x 95 4 accumulation accumulation NN cord-016652-x8t3lf1x 95 5 of of IN cord-016652-x8t3lf1x 95 6 viral viral JJ cord-016652-x8t3lf1x 95 7 proteins protein NNS cord-016652-x8t3lf1x 95 8 in in IN cord-016652-x8t3lf1x 95 9 the the DT cord-016652-x8t3lf1x 95 10 nucleolus nucleolus NN cord-016652-x8t3lf1x 95 11 could could MD cord-016652-x8t3lf1x 95 12 potentially potentially RB cord-016652-x8t3lf1x 95 13 cause cause VB cord-016652-x8t3lf1x 95 14 volume volume NN cord-016652-x8t3lf1x 95 15 exclusion exclusion NN cord-016652-x8t3lf1x 95 16 or or CC cord-016652-x8t3lf1x 95 17 crowding crowd VBG cord-016652-x8t3lf1x 95 18 effects effect NNS cord-016652-x8t3lf1x 95 19 , , , cord-016652-x8t3lf1x 95 20 which which WDT cord-016652-x8t3lf1x 95 21 have have VBP cord-016652-x8t3lf1x 95 22 been be VBN cord-016652-x8t3lf1x 95 23 proposed propose VBN cord-016652-x8t3lf1x 95 24 to to TO cord-016652-x8t3lf1x 95 25 play play VB cord-016652-x8t3lf1x 95 26 a a DT cord-016652-x8t3lf1x 95 27 fundamental fundamental JJ cord-016652-x8t3lf1x 95 28 role role NN cord-016652-x8t3lf1x 95 29 in in IN cord-016652-x8t3lf1x 95 30 the the DT cord-016652-x8t3lf1x 95 31 formation formation NN cord-016652-x8t3lf1x 95 32 of of IN cord-016652-x8t3lf1x 95 33 nuclear nuclear JJ cord-016652-x8t3lf1x 95 34 compartments compartment NNS cord-016652-x8t3lf1x 95 35 including include VBG cord-016652-x8t3lf1x 95 36 the the DT cord-016652-x8t3lf1x 95 37 nucleolus nucleolus NN cord-016652-x8t3lf1x 95 38 , , , cord-016652-x8t3lf1x 95 39 and and CC cord-016652-x8t3lf1x 95 40 can can MD cord-016652-x8t3lf1x 95 41 be be VB cord-016652-x8t3lf1x 95 42 addressed address VBN cord-016652-x8t3lf1x 95 43 by by IN cord-016652-x8t3lf1x 95 44 proteomic proteomic JJ cord-016652-x8t3lf1x 95 45 strategies strategy NNS cord-016652-x8t3lf1x 95 46 . . . cord-016652-x8t3lf1x 96 1 Therefore therefore RB cord-016652-x8t3lf1x 96 2 , , , cord-016652-x8t3lf1x 96 3 disruption disruption NN cord-016652-x8t3lf1x 96 4 of of IN cord-016652-x8t3lf1x 96 5 nucleolar nucleolar JJ cord-016652-x8t3lf1x 96 6 architecture architecture NN cord-016652-x8t3lf1x 96 7 and and CC cord-016652-x8t3lf1x 96 8 function function NN cord-016652-x8t3lf1x 96 9 might may MD cord-016652-x8t3lf1x 96 10 be be VB cord-016652-x8t3lf1x 96 11 common common JJ cord-016652-x8t3lf1x 96 12 in in IN cord-016652-x8t3lf1x 96 13 virus virus NN cord-016652-x8t3lf1x 96 14 - - HYPH cord-016652-x8t3lf1x 96 15 infected infect VBN cord-016652-x8t3lf1x 96 16 cells cell NNS cord-016652-x8t3lf1x 96 17 if if IN cord-016652-x8t3lf1x 96 18 viral viral JJ cord-016652-x8t3lf1x 96 19 proteins protein NNS cord-016652-x8t3lf1x 96 20 target target VBP cord-016652-x8t3lf1x 96 21 the the DT cord-016652-x8t3lf1x 96 22 nucleolus nucleolus NN cord-016652-x8t3lf1x 96 23 or or CC cord-016652-x8t3lf1x 96 24 a a DT cord-016652-x8t3lf1x 96 25 stage stage NN cord-016652-x8t3lf1x 96 26 of of IN cord-016652-x8t3lf1x 96 27 the the DT cord-016652-x8t3lf1x 96 28 virus virus NN cord-016652-x8t3lf1x 96 29 lifecycle lifecycle NN cord-016652-x8t3lf1x 96 30 disrupts disrupt VBZ cord-016652-x8t3lf1x 96 31 nucleolar nucleolar JJ cord-016652-x8t3lf1x 96 32 proteins protein NNS cord-016652-x8t3lf1x 96 33 . . . cord-016652-x8t3lf1x 97 1 For for IN cord-016652-x8t3lf1x 97 2 example example NN cord-016652-x8t3lf1x 97 3 , , , cord-016652-x8t3lf1x 97 4 poliovirus poliovirus NN cord-016652-x8t3lf1x 97 5 infection infection NN cord-016652-x8t3lf1x 97 6 results result VBZ cord-016652-x8t3lf1x 97 7 in in IN cord-016652-x8t3lf1x 97 8 the the DT cord-016652-x8t3lf1x 97 9 selective selective JJ cord-016652-x8t3lf1x 97 10 redistribution redistribution NN cord-016652-x8t3lf1x 97 11 of of IN cord-016652-x8t3lf1x 97 12 nucleolin nucleolin NN cord-016652-x8t3lf1x 97 13 from from IN cord-016652-x8t3lf1x 97 14 the the DT cord-016652-x8t3lf1x 97 15 nucleolus nucleolus NN cord-016652-x8t3lf1x 97 16 to to IN cord-016652-x8t3lf1x 97 17 the the DT cord-016652-x8t3lf1x 97 18 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 97 19 ( ( -LRB- cord-016652-x8t3lf1x 97 20 Waggoner Waggoner NNP cord-016652-x8t3lf1x 97 21 and and CC cord-016652-x8t3lf1x 97 22 Sarnow Sarnow NNP cord-016652-x8t3lf1x 97 23 1998 1998 CD cord-016652-x8t3lf1x 97 24 ) ) -RRB- cord-016652-x8t3lf1x 97 25 and and CC cord-016652-x8t3lf1x 97 26 inactivation inactivation NN cord-016652-x8t3lf1x 97 27 of of IN cord-016652-x8t3lf1x 97 28 UBF UBF NNP cord-016652-x8t3lf1x 97 29 , , , cord-016652-x8t3lf1x 97 30 which which WDT cord-016652-x8t3lf1x 97 31 shuts shut VBZ cord-016652-x8t3lf1x 97 32 off off RP cord-016652-x8t3lf1x 97 33 RNA rna NN cord-016652-x8t3lf1x 97 34 polymerase polymerase NN cord-016652-x8t3lf1x 97 35 I -PRON- PRP cord-016652-x8t3lf1x 97 36 transcription transcription VBP cord-016652-x8t3lf1x 97 37 in in IN cord-016652-x8t3lf1x 97 38 the the DT cord-016652-x8t3lf1x 97 39 host host NN cord-016652-x8t3lf1x 97 40 cell cell NN cord-016652-x8t3lf1x 97 41 . . . cord-016652-x8t3lf1x 98 1 The the DT cord-016652-x8t3lf1x 98 2 infection infection NN cord-016652-x8t3lf1x 98 3 of of IN cord-016652-x8t3lf1x 98 4 cells cell NNS cord-016652-x8t3lf1x 98 5 with with IN cord-016652-x8t3lf1x 98 6 IBV IBV NNP cord-016652-x8t3lf1x 98 7 has have VBZ cord-016652-x8t3lf1x 98 8 been be VBN cord-016652-x8t3lf1x 98 9 shown show VBN cord-016652-x8t3lf1x 98 10 to to TO cord-016652-x8t3lf1x 98 11 disrupt disrupt VB cord-016652-x8t3lf1x 98 12 nucleolar nucleolar JJ cord-016652-x8t3lf1x 98 13 architecture architecture NN cord-016652-x8t3lf1x 98 14 ( ( -LRB- cord-016652-x8t3lf1x 98 15 Dove Dove NNP cord-016652-x8t3lf1x 98 16 et et FW cord-016652-x8t3lf1x 98 17 al al NNP cord-016652-x8t3lf1x 98 18 . . . cord-016652-x8t3lf1x 98 19 2006b 2006b CD cord-016652-x8t3lf1x 98 20 ) ) -RRB- cord-016652-x8t3lf1x 98 21 and and CC cord-016652-x8t3lf1x 98 22 cause cause VB cord-016652-x8t3lf1x 98 23 arrest arrest NN cord-016652-x8t3lf1x 98 24 of of IN cord-016652-x8t3lf1x 98 25 the the DT cord-016652-x8t3lf1x 98 26 cell cell NN cord-016652-x8t3lf1x 98 27 cycle cycle NN cord-016652-x8t3lf1x 98 28 in in IN cord-016652-x8t3lf1x 98 29 the the DT cord-016652-x8t3lf1x 98 30 G2 G2 NNP cord-016652-x8t3lf1x 98 31 / / SYM cord-016652-x8t3lf1x 98 32 M M NNP cord-016652-x8t3lf1x 98 33 phase phase NN cord-016652-x8t3lf1x 98 34 and and CC cord-016652-x8t3lf1x 98 35 failure failure NN cord-016652-x8t3lf1x 98 36 of of IN cord-016652-x8t3lf1x 98 37 cytokinesis cytokinesis NN cord-016652-x8t3lf1x 99 1 ( ( -LRB- cord-016652-x8t3lf1x 99 2 Dove Dove NNP cord-016652-x8t3lf1x 99 3 et et FW cord-016652-x8t3lf1x 99 4 al al NNP cord-016652-x8t3lf1x 99 5 . . NNP cord-016652-x8t3lf1x 99 6 2006a 2006a CD cord-016652-x8t3lf1x 99 7 ) ) -RRB- cord-016652-x8t3lf1x 99 8 . . . cord-016652-x8t3lf1x 100 1 The the DT cord-016652-x8t3lf1x 100 2 IBV IBV NNP cord-016652-x8t3lf1x 100 3 and and CC cord-016652-x8t3lf1x 100 4 arterivirus arterivirus NNP cord-016652-x8t3lf1x 100 5 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 100 6 proteins protein NNS cord-016652-x8t3lf1x 100 7 associate associate JJ cord-016652-x8t3lf1x 100 8 with with IN cord-016652-x8t3lf1x 100 9 nucleolin nucleolin NNP cord-016652-x8t3lf1x 100 10 and and CC cord-016652-x8t3lf1x 100 11 fibrillarin fibrillarin NNP cord-016652-x8t3lf1x 100 12 , , , cord-016652-x8t3lf1x 100 13 respectively respectively RB cord-016652-x8t3lf1x 100 14 . . . cord-016652-x8t3lf1x 101 1 Similarly similarly RB cord-016652-x8t3lf1x 101 2 , , , cord-016652-x8t3lf1x 101 3 the the DT cord-016652-x8t3lf1x 101 4 HIV-1 HIV-1 NNP cord-016652-x8t3lf1x 101 5 Rev Rev NNP cord-016652-x8t3lf1x 101 6 protein protein NN cord-016652-x8t3lf1x 101 7 has have VBZ cord-016652-x8t3lf1x 101 8 been be VBN cord-016652-x8t3lf1x 101 9 shown show VBN cord-016652-x8t3lf1x 101 10 to to TO cord-016652-x8t3lf1x 101 11 localise localise VB cord-016652-x8t3lf1x 101 12 to to IN cord-016652-x8t3lf1x 101 13 the the DT cord-016652-x8t3lf1x 101 14 DFC DFC NNP cord-016652-x8t3lf1x 101 15 and and CC cord-016652-x8t3lf1x 101 16 GC GC NNP cord-016652-x8t3lf1x 101 17 and and CC cord-016652-x8t3lf1x 101 18 over over IN cord-016652-x8t3lf1x 101 19 - - HYPH cord-016652-x8t3lf1x 101 20 expression expression NN cord-016652-x8t3lf1x 101 21 of of IN cord-016652-x8t3lf1x 101 22 Rev Rev NNP cord-016652-x8t3lf1x 101 23 protein protein NN cord-016652-x8t3lf1x 101 24 alters alter VBZ cord-016652-x8t3lf1x 101 25 the the DT cord-016652-x8t3lf1x 101 26 nucleolar nucleolar JJ cord-016652-x8t3lf1x 101 27 architecture architecture NN cord-016652-x8t3lf1x 101 28 and and CC cord-016652-x8t3lf1x 101 29 is be VBZ cord-016652-x8t3lf1x 101 30 associated associate VBN cord-016652-x8t3lf1x 101 31 with with IN cord-016652-x8t3lf1x 101 32 the the DT cord-016652-x8t3lf1x 101 33 accumulation accumulation NN cord-016652-x8t3lf1x 101 34 of of IN cord-016652-x8t3lf1x 101 35 nucleophosmin nucleophosmin NNP cord-016652-x8t3lf1x 101 36 ( ( -LRB- cord-016652-x8t3lf1x 101 37 Dundr Dundr NNP cord-016652-x8t3lf1x 101 38 et et NNP cord-016652-x8t3lf1x 101 39 al al NNP cord-016652-x8t3lf1x 101 40 . . NNP cord-016652-x8t3lf1x 101 41 1995 1995 CD cord-016652-x8t3lf1x 101 42 ) ) -RRB- cord-016652-x8t3lf1x 101 43 . . . cord-016652-x8t3lf1x 102 1 Many many JJ cord-016652-x8t3lf1x 102 2 different different JJ cord-016652-x8t3lf1x 102 3 virus virus NN cord-016652-x8t3lf1x 102 4 proteins protein NNS cord-016652-x8t3lf1x 102 5 localise localise VBP cord-016652-x8t3lf1x 102 6 to to IN cord-016652-x8t3lf1x 102 7 the the DT cord-016652-x8t3lf1x 102 8 nucleolus nucleolus NN cord-016652-x8t3lf1x 102 9 ( ( -LRB- cord-016652-x8t3lf1x 102 10 Table table NN cord-016652-x8t3lf1x 102 11 14 14 CD cord-016652-x8t3lf1x 102 12 .1 .1 CD cord-016652-x8t3lf1x 102 13 ) ) -RRB- cord-016652-x8t3lf1x 102 14 . . . cord-016652-x8t3lf1x 103 1 However however RB cord-016652-x8t3lf1x 103 2 , , , cord-016652-x8t3lf1x 103 3 predicting predict VBG cord-016652-x8t3lf1x 103 4 viral viral JJ cord-016652-x8t3lf1x 103 5 ( ( -LRB- cord-016652-x8t3lf1x 103 6 and and CC cord-016652-x8t3lf1x 103 7 cellular cellular JJ cord-016652-x8t3lf1x 103 8 ) ) -RRB- cord-016652-x8t3lf1x 104 1 nucleolar nucleolar JJ cord-016652-x8t3lf1x 104 2 targeting target VBG cord-016652-x8t3lf1x 104 3 signals signal NNS cord-016652-x8t3lf1x 104 4 has have VBZ cord-016652-x8t3lf1x 104 5 historically historically RB cord-016652-x8t3lf1x 104 6 been be VBN cord-016652-x8t3lf1x 104 7 problematic problematic JJ cord-016652-x8t3lf1x 104 8 and and CC cord-016652-x8t3lf1x 104 9 only only RB cord-016652-x8t3lf1x 104 10 recently recently RB cord-016652-x8t3lf1x 104 11 has have VBZ cord-016652-x8t3lf1x 104 12 bioinformatic bioinformatic JJ cord-016652-x8t3lf1x 104 13 software software NN cord-016652-x8t3lf1x 104 14 been be VBN cord-016652-x8t3lf1x 104 15 developed develop VBN cord-016652-x8t3lf1x 104 16 to to TO cord-016652-x8t3lf1x 104 17 fascilitate fascilitate NNP cord-016652-x8t3lf1x 104 18 this this DT cord-016652-x8t3lf1x 104 19 ( ( -LRB- cord-016652-x8t3lf1x 104 20 Scott Scott NNP cord-016652-x8t3lf1x 104 21 et et NNP cord-016652-x8t3lf1x 104 22 al al NNP cord-016652-x8t3lf1x 104 23 . . NNP cord-016652-x8t3lf1x 104 24 2011 2011 CD cord-016652-x8t3lf1x 104 25 ) ) -RRB- cord-016652-x8t3lf1x 104 26 . . . cord-016652-x8t3lf1x 105 1 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 105 2 trafficking trafficking NN cord-016652-x8t3lf1x 105 3 might may MD cord-016652-x8t3lf1x 105 4 be be VB cord-016652-x8t3lf1x 105 5 mediated mediate VBN cord-016652-x8t3lf1x 105 6 by by IN cord-016652-x8t3lf1x 105 7 virtue virtue NN cord-016652-x8t3lf1x 105 8 of of IN cord-016652-x8t3lf1x 105 9 the the DT cord-016652-x8t3lf1x 105 10 fact fact NN cord-016652-x8t3lf1x 105 11 that that IN cord-016652-x8t3lf1x 105 12 viral viral JJ cord-016652-x8t3lf1x 105 13 proteins protein NNS cord-016652-x8t3lf1x 105 14 that that WDT cord-016652-x8t3lf1x 105 15 are be VBP cord-016652-x8t3lf1x 105 16 trafficked traffic VBN cord-016652-x8t3lf1x 105 17 to to IN cord-016652-x8t3lf1x 105 18 the the DT cord-016652-x8t3lf1x 105 19 nucleolus nucleolus NN cord-016652-x8t3lf1x 105 20 contain contain VBP cord-016652-x8t3lf1x 105 21 motifs motif NNS cord-016652-x8t3lf1x 105 22 that that WDT cord-016652-x8t3lf1x 105 23 resemble resemble VBP cord-016652-x8t3lf1x 105 24 host host NN cord-016652-x8t3lf1x 105 25 nucleolar nucleolar JJ cord-016652-x8t3lf1x 105 26 targeting target VBG cord-016652-x8t3lf1x 105 27 signals signal NNS cord-016652-x8t3lf1x 105 28 , , , cord-016652-x8t3lf1x 105 29 that that RB cord-016652-x8t3lf1x 105 30 is is RB cord-016652-x8t3lf1x 105 31 , , , cord-016652-x8t3lf1x 105 32 a a DT cord-016652-x8t3lf1x 105 33 form form NN cord-016652-x8t3lf1x 105 34 of of IN cord-016652-x8t3lf1x 105 35 molecular molecular JJ cord-016652-x8t3lf1x 105 36 mimicry mimicry NN cord-016652-x8t3lf1x 105 37 is be VBZ cord-016652-x8t3lf1x 105 38 used use VBN cord-016652-x8t3lf1x 105 39 . . . cord-016652-x8t3lf1x 106 1 The the DT cord-016652-x8t3lf1x 106 2 discovery discovery NN cord-016652-x8t3lf1x 106 3 of of IN cord-016652-x8t3lf1x 106 4 specific specific JJ cord-016652-x8t3lf1x 106 5 nucleolar nucleolar JJ cord-016652-x8t3lf1x 106 6 trafficking trafficking NN cord-016652-x8t3lf1x 106 7 signals signal NNS cord-016652-x8t3lf1x 106 8 in in IN cord-016652-x8t3lf1x 106 9 viral viral JJ cord-016652-x8t3lf1x 106 10 proteins protein NNS cord-016652-x8t3lf1x 106 11 has have VBZ cord-016652-x8t3lf1x 106 12 indicated indicate VBN cord-016652-x8t3lf1x 106 13 a a DT cord-016652-x8t3lf1x 106 14 functional functional JJ cord-016652-x8t3lf1x 106 15 mechanism mechanism NN cord-016652-x8t3lf1x 106 16 behind behind IN cord-016652-x8t3lf1x 106 17 this this DT cord-016652-x8t3lf1x 106 18 observed observe VBD cord-016652-x8t3lf1x 106 19 localisation localisation NN cord-016652-x8t3lf1x 106 20 ( ( -LRB- cord-016652-x8t3lf1x 106 21 Lee Lee NNP cord-016652-x8t3lf1x 106 22 et et NNP cord-016652-x8t3lf1x 106 23 al al NNP cord-016652-x8t3lf1x 106 24 . . NNP cord-016652-x8t3lf1x 106 25 2003 2003 CD cord-016652-x8t3lf1x 106 26 ; ; : cord-016652-x8t3lf1x 106 27 Reed Reed NNP cord-016652-x8t3lf1x 106 28 et et FW cord-016652-x8t3lf1x 106 29 al al NNP cord-016652-x8t3lf1x 106 30 . . . cord-016652-x8t3lf1x 106 31 2006 2006 CD cord-016652-x8t3lf1x 106 32 ; ; : cord-016652-x8t3lf1x 106 33 . . . cord-016652-x8t3lf1x 107 1 Analysis analysis NN cord-016652-x8t3lf1x 107 2 of of IN cord-016652-x8t3lf1x 107 3 the the DT cord-016652-x8t3lf1x 107 4 different different JJ cord-016652-x8t3lf1x 107 5 nucleolar nucleolar JJ cord-016652-x8t3lf1x 107 6 trafficking trafficking NN cord-016652-x8t3lf1x 107 7 signals signal NNS cord-016652-x8t3lf1x 107 8 identified identify VBN cord-016652-x8t3lf1x 107 9 in in IN cord-016652-x8t3lf1x 107 10 viral viral JJ cord-016652-x8t3lf1x 107 11 proteins protein NNS cord-016652-x8t3lf1x 107 12 using use VBG cord-016652-x8t3lf1x 107 13 dynamic dynamic JJ cord-016652-x8t3lf1x 107 14 live live JJ cord-016652-x8t3lf1x 107 15 - - HYPH cord-016652-x8t3lf1x 107 16 cell cell NN cord-016652-x8t3lf1x 107 17 imaging imaging NN cord-016652-x8t3lf1x 107 18 has have VBZ cord-016652-x8t3lf1x 107 19 certainly certainly RB cord-016652-x8t3lf1x 107 20 demonstrated demonstrate VBN cord-016652-x8t3lf1x 107 21 that that IN cord-016652-x8t3lf1x 107 22 different different JJ cord-016652-x8t3lf1x 107 23 proteins protein NNS cord-016652-x8t3lf1x 107 24 can can MD cord-016652-x8t3lf1x 107 25 confer confer VB cord-016652-x8t3lf1x 107 26 differential differential JJ cord-016652-x8t3lf1x 107 27 trafficking trafficking NN cord-016652-x8t3lf1x 107 28 rates rate NNS cord-016652-x8t3lf1x 107 29 and and CC cord-016652-x8t3lf1x 107 30 localisation localisation NN cord-016652-x8t3lf1x 107 31 patterns pattern NNS cord-016652-x8t3lf1x 107 32 ( ( -LRB- cord-016652-x8t3lf1x 107 33 Emmott Emmott NNP cord-016652-x8t3lf1x 107 34 et et NNP cord-016652-x8t3lf1x 107 35 al al NNP cord-016652-x8t3lf1x 107 36 . . NNP cord-016652-x8t3lf1x 107 37 2008 2008 CD cord-016652-x8t3lf1x 107 38 ) ) -RRB- cord-016652-x8t3lf1x 107 39 . . . cord-016652-x8t3lf1x 108 1 This this DT cord-016652-x8t3lf1x 108 2 is be VBZ cord-016652-x8t3lf1x 108 3 very very RB cord-016652-x8t3lf1x 108 4 similar similar JJ cord-016652-x8t3lf1x 108 5 to to IN cord-016652-x8t3lf1x 108 6 cellular cellular JJ cord-016652-x8t3lf1x 108 7 nucleolar nucleolar JJ cord-016652-x8t3lf1x 108 8 proteins protein NNS cord-016652-x8t3lf1x 109 1 ( ( -LRB- cord-016652-x8t3lf1x 109 2 Lechertier Lechertier NNP cord-016652-x8t3lf1x 109 3 et et NNP cord-016652-x8t3lf1x 109 4 al al NNP cord-016652-x8t3lf1x 109 5 . . NNP cord-016652-x8t3lf1x 109 6 2007 2007 CD cord-016652-x8t3lf1x 109 7 ) ) -RRB- cord-016652-x8t3lf1x 109 8 . . . cord-016652-x8t3lf1x 110 1 In in IN cord-016652-x8t3lf1x 110 2 some some DT cord-016652-x8t3lf1x 110 3 virus virus NN cord-016652-x8t3lf1x 110 4 proteins protein NNS cord-016652-x8t3lf1x 110 5 , , , cord-016652-x8t3lf1x 110 6 both both CC cord-016652-x8t3lf1x 110 7 NLSs nls NNS cord-016652-x8t3lf1x 110 8 and and CC cord-016652-x8t3lf1x 110 9 nucleolar nucleolar NN cord-016652-x8t3lf1x 110 10 targeting target VBG cord-016652-x8t3lf1x 110 11 signals signal NNS cord-016652-x8t3lf1x 110 12 act act VBP cord-016652-x8t3lf1x 110 13 in in IN cord-016652-x8t3lf1x 110 14 concert concert NN cord-016652-x8t3lf1x 110 15 to to TO cord-016652-x8t3lf1x 110 16 direct direct VB cord-016652-x8t3lf1x 110 17 a a DT cord-016652-x8t3lf1x 110 18 protein protein NN cord-016652-x8t3lf1x 110 19 to to IN cord-016652-x8t3lf1x 110 20 the the DT cord-016652-x8t3lf1x 110 21 nucleolus nucleolus NN cord-016652-x8t3lf1x 110 22 . . . cord-016652-x8t3lf1x 111 1 The the DT cord-016652-x8t3lf1x 111 2 arterivirus arterivirus NN cord-016652-x8t3lf1x 111 3 porcine porcine JJ cord-016652-x8t3lf1x 111 4 reproductive reproductive JJ cord-016652-x8t3lf1x 111 5 and and CC cord-016652-x8t3lf1x 111 6 respiratory respiratory JJ cord-016652-x8t3lf1x 111 7 syndrome syndrome NN cord-016652-x8t3lf1x 111 8 virus virus NN cord-016652-x8t3lf1x 111 9 ( ( -LRB- cord-016652-x8t3lf1x 111 10 PRRSV PRRSV NNP cord-016652-x8t3lf1x 111 11 ) ) -RRB- cord-016652-x8t3lf1x 111 12 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 111 13 protein protein NN cord-016652-x8t3lf1x 111 14 localises localise NNS cord-016652-x8t3lf1x 111 15 to to IN cord-016652-x8t3lf1x 111 16 the the DT cord-016652-x8t3lf1x 111 17 nucleolus nucleolus NN cord-016652-x8t3lf1x 111 18 and and CC cord-016652-x8t3lf1x 111 19 has have VBZ cord-016652-x8t3lf1x 111 20 been be VBN cord-016652-x8t3lf1x 111 21 shown show VBN cord-016652-x8t3lf1x 111 22 to to TO cord-016652-x8t3lf1x 111 23 contain contain VB cord-016652-x8t3lf1x 111 24 two two CD cord-016652-x8t3lf1x 111 25 potential potential JJ cord-016652-x8t3lf1x 111 26 NLSs nls NNS cord-016652-x8t3lf1x 111 27 , , , cord-016652-x8t3lf1x 111 28 a a DT cord-016652-x8t3lf1x 111 29 pat4 pat4 NN cord-016652-x8t3lf1x 111 30 and and CC cord-016652-x8t3lf1x 111 31 a a DT cord-016652-x8t3lf1x 111 32 downstream downstream JJ cord-016652-x8t3lf1x 111 33 pat7 pat7 NN cord-016652-x8t3lf1x 111 34 motif motif NN cord-016652-x8t3lf1x 112 1 ( ( -LRB- cord-016652-x8t3lf1x 112 2 Rowland Rowland NNP cord-016652-x8t3lf1x 112 3 et et NNP cord-016652-x8t3lf1x 112 4 al al NNP cord-016652-x8t3lf1x 112 5 . . . cord-016652-x8t3lf1x 113 1 1999 1999 CD cord-016652-x8t3lf1x 113 2 . . . cord-016652-x8t3lf1x 114 1 Analysis analysis NN cord-016652-x8t3lf1x 114 2 revealed reveal VBD cord-016652-x8t3lf1x 114 3 that that IN cord-016652-x8t3lf1x 114 4 a a DT cord-016652-x8t3lf1x 114 5 31 31 CD cord-016652-x8t3lf1x 114 6 amino amino NN cord-016652-x8t3lf1x 114 7 acid acid NN cord-016652-x8t3lf1x 114 8 sequence sequence NN cord-016652-x8t3lf1x 114 9 incorporating incorporate VBG cord-016652-x8t3lf1x 114 10 the the DT cord-016652-x8t3lf1x 114 11 pat7 pat7 JJ cord-016652-x8t3lf1x 114 12 motif motif NN cord-016652-x8t3lf1x 114 13 could could MD cord-016652-x8t3lf1x 114 14 direct direct VB cord-016652-x8t3lf1x 114 15 the the DT cord-016652-x8t3lf1x 114 16 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 114 17 protein protein NN cord-016652-x8t3lf1x 114 18 to to IN cord-016652-x8t3lf1x 114 19 both both CC cord-016652-x8t3lf1x 114 20 the the DT cord-016652-x8t3lf1x 114 21 nucleus nucleus NN cord-016652-x8t3lf1x 114 22 and and CC cord-016652-x8t3lf1x 114 23 nucleolus nucleolus NN cord-016652-x8t3lf1x 114 24 . . . cord-016652-x8t3lf1x 115 1 The the DT cord-016652-x8t3lf1x 115 2 protein protein NN cord-016652-x8t3lf1x 115 3 also also RB cord-016652-x8t3lf1x 115 4 contains contain VBZ cord-016652-x8t3lf1x 115 5 a a DT cord-016652-x8t3lf1x 115 6 predicted predict VBN cord-016652-x8t3lf1x 115 7 NES NES NNP cord-016652-x8t3lf1x 115 8 , , , cord-016652-x8t3lf1x 115 9 presumably presumably RB cord-016652-x8t3lf1x 115 10 to to TO cord-016652-x8t3lf1x 115 11 allow allow VB cord-016652-x8t3lf1x 115 12 the the DT cord-016652-x8t3lf1x 115 13 protein protein NN cord-016652-x8t3lf1x 115 14 to to TO cord-016652-x8t3lf1x 115 15 traffic traffic NN cord-016652-x8t3lf1x 115 16 back back RB cord-016652-x8t3lf1x 115 17 into into IN cord-016652-x8t3lf1x 115 18 the the DT cord-016652-x8t3lf1x 115 19 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 115 20 to to TO cord-016652-x8t3lf1x 115 21 contribute contribute VB cord-016652-x8t3lf1x 115 22 to to IN cord-016652-x8t3lf1x 115 23 viral viral JJ cord-016652-x8t3lf1x 115 24 function function NN cord-016652-x8t3lf1x 115 25 in in IN cord-016652-x8t3lf1x 115 26 this this DT cord-016652-x8t3lf1x 115 27 compartment compartment NN cord-016652-x8t3lf1x 115 28 . . . cord-016652-x8t3lf1x 116 1 This this DT cord-016652-x8t3lf1x 116 2 is be VBZ cord-016652-x8t3lf1x 116 3 common common JJ cord-016652-x8t3lf1x 116 4 with with IN cord-016652-x8t3lf1x 116 5 other other JJ cord-016652-x8t3lf1x 116 6 similar similar JJ cord-016652-x8t3lf1x 116 7 related related JJ cord-016652-x8t3lf1x 116 8 proteins protein NNS cord-016652-x8t3lf1x 116 9 . . . cord-016652-x8t3lf1x 117 1 For for IN cord-016652-x8t3lf1x 117 2 example example NN cord-016652-x8t3lf1x 117 3 , , , cord-016652-x8t3lf1x 117 4 in in IN cord-016652-x8t3lf1x 117 5 the the DT cord-016652-x8t3lf1x 117 6 avian avian JJ cord-016652-x8t3lf1x 117 7 coronavirus coronavirus NN cord-016652-x8t3lf1x 117 8 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 117 9 protein protein VB cord-016652-x8t3lf1x 117 10 an an DT cord-016652-x8t3lf1x 117 11 eight eight CD cord-016652-x8t3lf1x 117 12 amino amino NN cord-016652-x8t3lf1x 117 13 acid acid NN cord-016652-x8t3lf1x 117 14 sequence sequence NN cord-016652-x8t3lf1x 117 15 is be VBZ cord-016652-x8t3lf1x 117 16 necessary necessary JJ cord-016652-x8t3lf1x 117 17 and and CC cord-016652-x8t3lf1x 117 18 sufficient sufficient JJ cord-016652-x8t3lf1x 117 19 to to TO cord-016652-x8t3lf1x 117 20 target target VB cord-016652-x8t3lf1x 117 21 the the DT cord-016652-x8t3lf1x 117 22 protein protein NN cord-016652-x8t3lf1x 117 23 to to IN cord-016652-x8t3lf1x 117 24 the the DT cord-016652-x8t3lf1x 117 25 nucleolus nucleolus NN cord-016652-x8t3lf1x 117 26 ( ( -LRB- cord-016652-x8t3lf1x 117 27 Reed Reed NNP cord-016652-x8t3lf1x 117 28 et et FW cord-016652-x8t3lf1x 117 29 al al NNP cord-016652-x8t3lf1x 117 30 . . . cord-016652-x8t3lf1x 117 31 2006 2006 CD cord-016652-x8t3lf1x 117 32 ) ) -RRB- cord-016652-x8t3lf1x 117 33 and and CC cord-016652-x8t3lf1x 117 34 contains contain VBZ cord-016652-x8t3lf1x 117 35 an an DT cord-016652-x8t3lf1x 117 36 NES NES NNP cord-016652-x8t3lf1x 117 37 ( ( -LRB- cord-016652-x8t3lf1x 117 38 Reed Reed NNP cord-016652-x8t3lf1x 117 39 et et FW cord-016652-x8t3lf1x 117 40 al al NNP cord-016652-x8t3lf1x 117 41 . . NNP cord-016652-x8t3lf1x 117 42 2007 2007 CD cord-016652-x8t3lf1x 117 43 ) ) -RRB- cord-016652-x8t3lf1x 117 44 . . . cord-016652-x8t3lf1x 118 1 Intriguingly intriguingly RB cord-016652-x8t3lf1x 118 2 , , , cord-016652-x8t3lf1x 118 3 genetic genetic JJ cord-016652-x8t3lf1x 118 4 analysis analysis NN cord-016652-x8t3lf1x 119 1 ( ( -LRB- cord-016652-x8t3lf1x 119 2 Lee Lee NNP cord-016652-x8t3lf1x 119 3 et et NNP cord-016652-x8t3lf1x 119 4 al al NNP cord-016652-x8t3lf1x 119 5 . . . cord-016652-x8t3lf1x 119 6 2006 2006 CD cord-016652-x8t3lf1x 119 7 ) ) -RRB- cord-016652-x8t3lf1x 119 8 , , , cord-016652-x8t3lf1x 119 9 dynamic dynamic JJ cord-016652-x8t3lf1x 119 10 livecell livecell NNP cord-016652-x8t3lf1x 119 11 imaging imaging NN cord-016652-x8t3lf1x 120 1 ( ( -LRB- cord-016652-x8t3lf1x 120 2 You -PRON- PRP cord-016652-x8t3lf1x 120 3 et et FW cord-016652-x8t3lf1x 120 4 al al NNP cord-016652-x8t3lf1x 120 5 . . NNP cord-016652-x8t3lf1x 120 6 2008 2008 CD cord-016652-x8t3lf1x 120 7 ) ) -RRB- cord-016652-x8t3lf1x 120 8 and and CC cord-016652-x8t3lf1x 120 9 use use NN cord-016652-x8t3lf1x 120 10 of of IN cord-016652-x8t3lf1x 120 11 trafficking traffic VBG cord-016652-x8t3lf1x 120 12 inhibitors inhibitor NNS cord-016652-x8t3lf1x 120 13 ( ( -LRB- cord-016652-x8t3lf1x 120 14 Tijms Tijms NNP cord-016652-x8t3lf1x 120 15 et et NNP cord-016652-x8t3lf1x 120 16 al al NNP cord-016652-x8t3lf1x 120 17 . . . cord-016652-x8t3lf1x 120 18 2002 2002 CD cord-016652-x8t3lf1x 120 19 ) ) -RRB- cord-016652-x8t3lf1x 120 20 paint paint VBP cord-016652-x8t3lf1x 120 21 a a DT cord-016652-x8t3lf1x 120 22 picture picture NN cord-016652-x8t3lf1x 120 23 of of IN cord-016652-x8t3lf1x 120 24 the the DT cord-016652-x8t3lf1x 120 25 requirement requirement NN cord-016652-x8t3lf1x 120 26 of of IN cord-016652-x8t3lf1x 120 27 these these DT cord-016652-x8t3lf1x 120 28 positive positive JJ cord-016652-x8t3lf1x 120 29 sense sense NN cord-016652-x8t3lf1x 121 1 RNA RNA NNP cord-016652-x8t3lf1x 121 2 virus virus NN cord-016652-x8t3lf1x 121 3 capsid capsid NN cord-016652-x8t3lf1x 121 4 proteins protein VBZ cord-016652-x8t3lf1x 121 5 localising localise VBG cord-016652-x8t3lf1x 121 6 to to IN cord-016652-x8t3lf1x 121 7 the the DT cord-016652-x8t3lf1x 121 8 nucleolus nucleolus NN cord-016652-x8t3lf1x 121 9 as as RB cord-016652-x8t3lf1x 121 10 soon soon RB cord-016652-x8t3lf1x 121 11 as as IN cord-016652-x8t3lf1x 121 12 they -PRON- PRP cord-016652-x8t3lf1x 121 13 are be VBP cord-016652-x8t3lf1x 121 14 translated translate VBN cord-016652-x8t3lf1x 121 15 , , , cord-016652-x8t3lf1x 121 16 prior prior RB cord-016652-x8t3lf1x 121 17 to to IN cord-016652-x8t3lf1x 121 18 their -PRON- PRP$ cord-016652-x8t3lf1x 121 19 involvement involvement NN cord-016652-x8t3lf1x 121 20 in in IN cord-016652-x8t3lf1x 121 21 virus virus NN cord-016652-x8t3lf1x 121 22 replication replication NN cord-016652-x8t3lf1x 121 23 or or CC cord-016652-x8t3lf1x 121 24 assembly assembly NN cord-016652-x8t3lf1x 121 25 . . . cord-016652-x8t3lf1x 122 1 This this DT cord-016652-x8t3lf1x 122 2 may may MD cord-016652-x8t3lf1x 122 3 be be VB cord-016652-x8t3lf1x 122 4 related relate VBN cord-016652-x8t3lf1x 122 5 to to IN cord-016652-x8t3lf1x 122 6 subversion subversion NN cord-016652-x8t3lf1x 122 7 of of IN cord-016652-x8t3lf1x 122 8 host host NN cord-016652-x8t3lf1x 122 9 cell cell NN cord-016652-x8t3lf1x 122 10 function function NN cord-016652-x8t3lf1x 122 11 , , , cord-016652-x8t3lf1x 122 12 protein protein NN cord-016652-x8t3lf1x 122 13 modification modification NN cord-016652-x8t3lf1x 122 14 ( ( -LRB- cord-016652-x8t3lf1x 122 15 e.g. e.g. IN cord-016652-x8t3lf1x 122 16 phosphorylation phosphorylation NN cord-016652-x8t3lf1x 122 17 ) ) -RRB- cord-016652-x8t3lf1x 122 18 or or CC cord-016652-x8t3lf1x 122 19 recruitment recruitment NN cord-016652-x8t3lf1x 122 20 of of IN cord-016652-x8t3lf1x 122 21 nucleolar nucleolar JJ cord-016652-x8t3lf1x 122 22 proteins protein NNS cord-016652-x8t3lf1x 122 23 . . . cord-016652-x8t3lf1x 123 1 Viral viral JJ cord-016652-x8t3lf1x 123 2 proteins protein NNS cord-016652-x8t3lf1x 123 3 might may MD cord-016652-x8t3lf1x 123 4 also also RB cord-016652-x8t3lf1x 123 5 traffic traffic VB cord-016652-x8t3lf1x 123 6 to to IN cord-016652-x8t3lf1x 123 7 the the DT cord-016652-x8t3lf1x 123 8 nucleolus nucleolus NN cord-016652-x8t3lf1x 123 9 through through IN cord-016652-x8t3lf1x 123 10 association association NNP cord-016652-x8t3lf1x 123 11 with with IN cord-016652-x8t3lf1x 123 12 cellular cellular JJ cord-016652-x8t3lf1x 123 13 nucleolar nucleolar JJ cord-016652-x8t3lf1x 123 14 proteins protein NNS cord-016652-x8t3lf1x 123 15 . . . cord-016652-x8t3lf1x 124 1 For for IN cord-016652-x8t3lf1x 124 2 example example NN cord-016652-x8t3lf1x 124 3 , , , cord-016652-x8t3lf1x 124 4 the the DT cord-016652-x8t3lf1x 124 5 hepatitis hepatitis NN cord-016652-x8t3lf1x 124 6 delta delta NNP cord-016652-x8t3lf1x 124 7 antigen antigen NNP cord-016652-x8t3lf1x 124 8 has have VBZ cord-016652-x8t3lf1x 124 9 been be VBN cord-016652-x8t3lf1x 124 10 shown show VBN cord-016652-x8t3lf1x 124 11 to to TO cord-016652-x8t3lf1x 124 12 contain contain VB cord-016652-x8t3lf1x 124 13 a a DT cord-016652-x8t3lf1x 124 14 nucleolar nucleolar JJ cord-016652-x8t3lf1x 124 15 targeting target VBG cord-016652-x8t3lf1x 124 16 signal signal NN cord-016652-x8t3lf1x 124 17 that that WDT cord-016652-x8t3lf1x 124 18 also also RB cord-016652-x8t3lf1x 124 19 corresponded correspond VBD cord-016652-x8t3lf1x 124 20 to to IN cord-016652-x8t3lf1x 124 21 a a DT cord-016652-x8t3lf1x 124 22 site site NN cord-016652-x8t3lf1x 124 23 that that WDT cord-016652-x8t3lf1x 124 24 promoted promote VBD cord-016652-x8t3lf1x 124 25 binding binding NN cord-016652-x8t3lf1x 124 26 to to IN cord-016652-x8t3lf1x 124 27 nucleolin nucleolin NNP cord-016652-x8t3lf1x 124 28 ( ( -LRB- cord-016652-x8t3lf1x 124 29 Lee Lee NNP cord-016652-x8t3lf1x 124 30 et et NNP cord-016652-x8t3lf1x 124 31 al al NNP cord-016652-x8t3lf1x 124 32 . . NNP cord-016652-x8t3lf1x 124 33 1998 1998 CD cord-016652-x8t3lf1x 124 34 ) ) -RRB- cord-016652-x8t3lf1x 124 35 . . . cord-016652-x8t3lf1x 125 1 Mutating mutate VBG cord-016652-x8t3lf1x 125 2 this this DT cord-016652-x8t3lf1x 125 3 region region NN cord-016652-x8t3lf1x 125 4 prevented prevent VBD cord-016652-x8t3lf1x 125 5 nucleolin nucleolin NNP cord-016652-x8t3lf1x 125 6 binding bind VBG cord-016652-x8t3lf1x 125 7 to to IN cord-016652-x8t3lf1x 125 8 the the DT cord-016652-x8t3lf1x 125 9 delta delta NN cord-016652-x8t3lf1x 125 10 antigen antigen NN cord-016652-x8t3lf1x 125 11 and and CC cord-016652-x8t3lf1x 125 12 nucleolar nucleolar JJ cord-016652-x8t3lf1x 125 13 trafficking trafficking NN cord-016652-x8t3lf1x 125 14 . . . cord-016652-x8t3lf1x 126 1 By by IN cord-016652-x8t3lf1x 126 2 implication implication NN cord-016652-x8t3lf1x 126 3 , , , cord-016652-x8t3lf1x 126 4 this this DT cord-016652-x8t3lf1x 126 5 relates relate VBZ cord-016652-x8t3lf1x 126 6 nucleolin nucleolin NN cord-016652-x8t3lf1x 126 7 binding bind VBG cord-016652-x8t3lf1x 126 8 to to IN cord-016652-x8t3lf1x 126 9 nucleolar nucleolar JJ cord-016652-x8t3lf1x 126 10 trafficking traffic VBG cord-016652-x8t3lf1x 126 11 ( ( -LRB- cord-016652-x8t3lf1x 126 12 Lee Lee NNP cord-016652-x8t3lf1x 126 13 et et NNP cord-016652-x8t3lf1x 126 14 al al NNP cord-016652-x8t3lf1x 126 15 . . NNP cord-016652-x8t3lf1x 126 16 1998 1998 CD cord-016652-x8t3lf1x 126 17 ) ) -RRB- cord-016652-x8t3lf1x 126 18 . . . cord-016652-x8t3lf1x 127 1 Certainly certainly RB cord-016652-x8t3lf1x 127 2 , , , cord-016652-x8t3lf1x 127 3 interaction interaction NN cord-016652-x8t3lf1x 127 4 with with IN cord-016652-x8t3lf1x 127 5 nucleophosmin nucleophosmin NNP cord-016652-x8t3lf1x 127 6 and and CC cord-016652-x8t3lf1x 127 7 hepatitis hepatitis NNP cord-016652-x8t3lf1x 127 8 delta delta NNP cord-016652-x8t3lf1x 127 9 antigens antigen NNS cord-016652-x8t3lf1x 127 10 can can MD cord-016652-x8t3lf1x 127 11 modulate modulate VB cord-016652-x8t3lf1x 127 12 viral viral JJ cord-016652-x8t3lf1x 127 13 replication replication NN cord-016652-x8t3lf1x 127 14 ( ( -LRB- cord-016652-x8t3lf1x 127 15 Huang Huang NNP cord-016652-x8t3lf1x 127 16 et et NNP cord-016652-x8t3lf1x 127 17 al al NNP cord-016652-x8t3lf1x 127 18 . . NNP cord-016652-x8t3lf1x 127 19 2001 2001 CD cord-016652-x8t3lf1x 127 20 ) ) -RRB- cord-016652-x8t3lf1x 127 21 and and CC cord-016652-x8t3lf1x 127 22 more more RBR cord-016652-x8t3lf1x 127 23 recently recently RB cord-016652-x8t3lf1x 127 24 combined combine VBN cord-016652-x8t3lf1x 127 25 proteomic proteomic NN cord-016652-x8t3lf1x 127 26 - - HYPH cord-016652-x8t3lf1x 127 27 RNAi RNAi NNS cord-016652-x8t3lf1x 127 28 screens screen NNS cord-016652-x8t3lf1x 127 29 have have VBP cord-016652-x8t3lf1x 127 30 revealed reveal VBN cord-016652-x8t3lf1x 127 31 many many JJ cord-016652-x8t3lf1x 127 32 other other JJ cord-016652-x8t3lf1x 127 33 nucleolar nucleolar JJ cord-016652-x8t3lf1x 127 34 proteins protein NNS cord-016652-x8t3lf1x 127 35 that that WDT cord-016652-x8t3lf1x 127 36 can can MD cord-016652-x8t3lf1x 127 37 be be VB cord-016652-x8t3lf1x 127 38 associated associate VBN cord-016652-x8t3lf1x 127 39 with with IN cord-016652-x8t3lf1x 127 40 this this DT cord-016652-x8t3lf1x 127 41 viral viral JJ cord-016652-x8t3lf1x 127 42 protein protein NN cord-016652-x8t3lf1x 127 43 ( ( -LRB- cord-016652-x8t3lf1x 127 44 Cao Cao NNP cord-016652-x8t3lf1x 127 45 et et NNP cord-016652-x8t3lf1x 127 46 al al NNP cord-016652-x8t3lf1x 127 47 . . NNP cord-016652-x8t3lf1x 127 48 2009 2009 CD cord-016652-x8t3lf1x 127 49 ) ) -RRB- cord-016652-x8t3lf1x 127 50 . . . cord-016652-x8t3lf1x 128 1 Trafficking trafficking NN cord-016652-x8t3lf1x 128 2 and and CC cord-016652-x8t3lf1x 128 3 accumulation accumulation NN cord-016652-x8t3lf1x 128 4 of of IN cord-016652-x8t3lf1x 128 5 viral viral JJ cord-016652-x8t3lf1x 128 6 proteins protein NNS cord-016652-x8t3lf1x 128 7 to to IN cord-016652-x8t3lf1x 128 8 and and CC cord-016652-x8t3lf1x 128 9 from from IN cord-016652-x8t3lf1x 128 10 the the DT cord-016652-x8t3lf1x 128 11 nucleolus nucleolus NN cord-016652-x8t3lf1x 128 12 , , , cord-016652-x8t3lf1x 128 13 similar similar JJ cord-016652-x8t3lf1x 128 14 to to IN cord-016652-x8t3lf1x 128 15 cellular cellular JJ cord-016652-x8t3lf1x 128 16 proteins protein NNS cord-016652-x8t3lf1x 128 17 , , , cord-016652-x8t3lf1x 128 18 may may MD cord-016652-x8t3lf1x 128 19 also also RB cord-016652-x8t3lf1x 128 20 be be VB cord-016652-x8t3lf1x 128 21 cell cell NN cord-016652-x8t3lf1x 128 22 cycle cycle NN cord-016652-x8t3lf1x 128 23 related relate VBN cord-016652-x8t3lf1x 128 24 . . . cord-016652-x8t3lf1x 129 1 For for IN cord-016652-x8t3lf1x 129 2 example example NN cord-016652-x8t3lf1x 129 3 , , , cord-016652-x8t3lf1x 129 4 the the DT cord-016652-x8t3lf1x 129 5 coronavirus coronavirus NN cord-016652-x8t3lf1x 129 6 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 129 7 protein protein NN cord-016652-x8t3lf1x 129 8 localises localise NNS cord-016652-x8t3lf1x 129 9 preferentially preferentially RB cord-016652-x8t3lf1x 129 10 to to IN cord-016652-x8t3lf1x 129 11 the the DT cord-016652-x8t3lf1x 129 12 nucleolus nucleolus NN cord-016652-x8t3lf1x 129 13 in in IN cord-016652-x8t3lf1x 129 14 the the DT cord-016652-x8t3lf1x 129 15 G2 G2 NNP cord-016652-x8t3lf1x 129 16 phase phase NN cord-016652-x8t3lf1x 129 17 of of IN cord-016652-x8t3lf1x 129 18 the the DT cord-016652-x8t3lf1x 129 19 cell cell NN cord-016652-x8t3lf1x 129 20 cycle cycle NN cord-016652-x8t3lf1x 129 21 ( ( -LRB- cord-016652-x8t3lf1x 129 22 Cawood Cawood NNP cord-016652-x8t3lf1x 129 23 et et NNP cord-016652-x8t3lf1x 129 24 al al NNP cord-016652-x8t3lf1x 129 25 . . NNP cord-016652-x8t3lf1x 129 26 2007 2007 CD cord-016652-x8t3lf1x 129 27 ) ) -RRB- cord-016652-x8t3lf1x 129 28 , , , cord-016652-x8t3lf1x 129 29 as as IN cord-016652-x8t3lf1x 129 30 does do VBZ cord-016652-x8t3lf1x 129 31 the the DT cord-016652-x8t3lf1x 129 32 human human JJ cord-016652-x8t3lf1x 129 33 cytomegalovirus cytomegalovirus NN cord-016652-x8t3lf1x 129 34 protein protein NN cord-016652-x8t3lf1x 129 35 UL83 UL83 NNP cord-016652-x8t3lf1x 129 36 in in IN cord-016652-x8t3lf1x 129 37 the the DT cord-016652-x8t3lf1x 129 38 G1 G1 NNP cord-016652-x8t3lf1x 129 39 phase phase NN cord-016652-x8t3lf1x 129 40 ( ( -LRB- cord-016652-x8t3lf1x 129 41 Arcangeletti Arcangeletti NNP cord-016652-x8t3lf1x 129 42 et et NNP cord-016652-x8t3lf1x 129 43 al al NNP cord-016652-x8t3lf1x 129 44 . . NNP cord-016652-x8t3lf1x 129 45 2011 2011 CD cord-016652-x8t3lf1x 129 46 ) ) -RRB- cord-016652-x8t3lf1x 129 47 . . . cord-016652-x8t3lf1x 130 1 Again again RB cord-016652-x8t3lf1x 130 2 these these DT cord-016652-x8t3lf1x 130 3 trafficking traffic VBG cord-016652-x8t3lf1x 130 4 profiles profile NNS cord-016652-x8t3lf1x 130 5 may may MD cord-016652-x8t3lf1x 130 6 be be VB cord-016652-x8t3lf1x 130 7 related relate VBN cord-016652-x8t3lf1x 130 8 to to IN cord-016652-x8t3lf1x 130 9 the the DT cord-016652-x8t3lf1x 130 10 interaction interaction NN cord-016652-x8t3lf1x 130 11 with with IN cord-016652-x8t3lf1x 130 12 cellular cellular JJ cord-016652-x8t3lf1x 130 13 nucleolar nucleolar JJ cord-016652-x8t3lf1x 130 14 proteins protein NNS cord-016652-x8t3lf1x 130 15 ( ( -LRB- cord-016652-x8t3lf1x 130 16 Emmott Emmott NNP cord-016652-x8t3lf1x 130 17 and and CC cord-016652-x8t3lf1x 130 18 Hiscox Hiscox NNP cord-016652-x8t3lf1x 130 19 2009 2009 CD cord-016652-x8t3lf1x 130 20 ) ) -RRB- cord-016652-x8t3lf1x 130 21 . . . cord-016652-x8t3lf1x 131 1 Semliki Semliki NNP cord-016652-x8t3lf1x 131 2 Forest Forest NNP cord-016652-x8t3lf1x 131 3 virus virus NN cord-016652-x8t3lf1x 131 4 non non JJ cord-016652-x8t3lf1x 131 5 - - JJ cord-016652-x8t3lf1x 131 6 structural structural JJ cord-016652-x8t3lf1x 131 7 protein protein NN cord-016652-x8t3lf1x 131 8 nsP2 nsp2 NN cord-016652-x8t3lf1x 131 9 can can MD cord-016652-x8t3lf1x 131 10 localise localise VB cord-016652-x8t3lf1x 131 11 to to IN cord-016652-x8t3lf1x 131 12 the the DT cord-016652-x8t3lf1x 131 13 nucleolus nucleolus NN cord-016652-x8t3lf1x 132 1 ( ( -LRB- cord-016652-x8t3lf1x 132 2 Peranen Peranen NNP cord-016652-x8t3lf1x 132 3 et et NNP cord-016652-x8t3lf1x 132 4 al al NNP cord-016652-x8t3lf1x 132 5 . . . cord-016652-x8t3lf1x 132 6 1990 1990 CD cord-016652-x8t3lf1x 133 1 ; ; : cord-016652-x8t3lf1x 133 2 Rikkonen Rikkonen NNP cord-016652-x8t3lf1x 133 3 et et FW cord-016652-x8t3lf1x 133 4 al al NNP cord-016652-x8t3lf1x 133 5 . . . cord-016652-x8t3lf1x 133 6 1992 1992 CD cord-016652-x8t3lf1x 134 1 Rikkonen Rikkonen NNP cord-016652-x8t3lf1x 134 2 et et FW cord-016652-x8t3lf1x 134 3 al al NNP cord-016652-x8t3lf1x 134 4 . . . cord-016652-x8t3lf1x 135 1 , , , cord-016652-x8t3lf1x 135 2 1994 1994 CD cord-016652-x8t3lf1x 135 3 and and CC cord-016652-x8t3lf1x 135 4 disruption disruption NN cord-016652-x8t3lf1x 135 5 of of IN cord-016652-x8t3lf1x 135 6 this this DT cord-016652-x8t3lf1x 135 7 localisation localisation NN cord-016652-x8t3lf1x 135 8 through through IN cord-016652-x8t3lf1x 135 9 a a DT cord-016652-x8t3lf1x 135 10 single single JJ cord-016652-x8t3lf1x 135 11 amino amino NN cord-016652-x8t3lf1x 135 12 acid acid NN cord-016652-x8t3lf1x 135 13 change change NN cord-016652-x8t3lf1x 135 14 results result NNS cord-016652-x8t3lf1x 135 15 in in IN cord-016652-x8t3lf1x 135 16 a a DT cord-016652-x8t3lf1x 135 17 reduction reduction NN cord-016652-x8t3lf1x 135 18 in in IN cord-016652-x8t3lf1x 135 19 neurovirulence neurovirulence NNP cord-016652-x8t3lf1x 136 1 ( ( -LRB- cord-016652-x8t3lf1x 136 2 Fazakerley Fazakerley NNP cord-016652-x8t3lf1x 136 3 et et NNP cord-016652-x8t3lf1x 136 4 al al NNP cord-016652-x8t3lf1x 136 5 . . . cord-016652-x8t3lf1x 136 6 2002 2002 CD cord-016652-x8t3lf1x 136 7 ) ) -RRB- cord-016652-x8t3lf1x 136 8 . . . cord-016652-x8t3lf1x 137 1 Such such JJ cord-016652-x8t3lf1x 137 2 in in IN cord-016652-x8t3lf1x 137 3 vitro vitro FW cord-016652-x8t3lf1x 137 4 data data NN cord-016652-x8t3lf1x 137 5 has have VBZ cord-016652-x8t3lf1x 137 6 also also RB cord-016652-x8t3lf1x 137 7 been be VBN cord-016652-x8t3lf1x 137 8 backed back VBN cord-016652-x8t3lf1x 137 9 up up RP cord-016652-x8t3lf1x 137 10 by by IN cord-016652-x8t3lf1x 137 11 persuasive persuasive JJ cord-016652-x8t3lf1x 137 12 in in IN cord-016652-x8t3lf1x 137 13 vivo vivo NNP cord-016652-x8t3lf1x 137 14 data datum NNS cord-016652-x8t3lf1x 137 15 . . . cord-016652-x8t3lf1x 138 1 Mutation mutation NN cord-016652-x8t3lf1x 138 2 of of IN cord-016652-x8t3lf1x 138 3 the the DT cord-016652-x8t3lf1x 138 4 arterivirus arterivirus NNP cord-016652-x8t3lf1x 138 5 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 138 6 protein protein NNP cord-016652-x8t3lf1x 138 7 pat7 pat7 CD cord-016652-x8t3lf1x 138 8 NLS NLS NNP cord-016652-x8t3lf1x 138 9 motif motif NN cord-016652-x8t3lf1x 138 10 in in IN cord-016652-x8t3lf1x 138 11 the the DT cord-016652-x8t3lf1x 138 12 context context NN cord-016652-x8t3lf1x 138 13 of of IN cord-016652-x8t3lf1x 138 14 a a DT cord-016652-x8t3lf1x 138 15 full full JJ cord-016652-x8t3lf1x 138 16 - - HYPH cord-016652-x8t3lf1x 138 17 length length NN cord-016652-x8t3lf1x 138 18 clone clone NN cord-016652-x8t3lf1x 138 19 revealed reveal VBD cord-016652-x8t3lf1x 138 20 that that IN cord-016652-x8t3lf1x 138 21 this this DT cord-016652-x8t3lf1x 138 22 sequence sequence NN cord-016652-x8t3lf1x 138 23 could could MD cord-016652-x8t3lf1x 138 24 have have VB cord-016652-x8t3lf1x 138 25 a a DT cord-016652-x8t3lf1x 138 26 key key JJ cord-016652-x8t3lf1x 138 27 role role NN cord-016652-x8t3lf1x 138 28 in in IN cord-016652-x8t3lf1x 138 29 virus virus NN cord-016652-x8t3lf1x 138 30 pathogenesis pathogenesis NN cord-016652-x8t3lf1x 138 31 in in IN cord-016652-x8t3lf1x 138 32 vivo vivo NN cord-016652-x8t3lf1x 138 33 , , , cord-016652-x8t3lf1x 138 34 as as IN cord-016652-x8t3lf1x 138 35 animals animal NNS cord-016652-x8t3lf1x 138 36 infected infect VBN cord-016652-x8t3lf1x 138 37 with with IN cord-016652-x8t3lf1x 138 38 mutant mutant JJ cord-016652-x8t3lf1x 138 39 viruses virus NNS cord-016652-x8t3lf1x 138 40 had have VBD cord-016652-x8t3lf1x 138 41 shorter short JJR cord-016652-x8t3lf1x 138 42 viraemia viraemia NN cord-016652-x8t3lf1x 138 43 than than IN cord-016652-x8t3lf1x 138 44 wild wild JJ cord-016652-x8t3lf1x 138 45 - - HYPH cord-016652-x8t3lf1x 138 46 type type NN cord-016652-x8t3lf1x 138 47 viruses virus NNS cord-016652-x8t3lf1x 139 1 ( ( -LRB- cord-016652-x8t3lf1x 139 2 Lee Lee NNP cord-016652-x8t3lf1x 139 3 et et NNP cord-016652-x8t3lf1x 139 4 al al NNP cord-016652-x8t3lf1x 139 5 . . . cord-016652-x8t3lf1x 140 1 2006 2006 CD cord-016652-x8t3lf1x 140 2 ; ; : cord-016652-x8t3lf1x 140 3 Pei Pei NNP cord-016652-x8t3lf1x 140 4 et et NNP cord-016652-x8t3lf1x 140 5 al al NNP cord-016652-x8t3lf1x 140 6 . . NNP cord-016652-x8t3lf1x 140 7 2008 2008 CD cord-016652-x8t3lf1x 140 8 ) ) -RRB- cord-016652-x8t3lf1x 140 9 . . . cord-016652-x8t3lf1x 141 1 Interestingly interestingly RB cord-016652-x8t3lf1x 141 2 , , , cord-016652-x8t3lf1x 141 3 reversions reversion NNS cord-016652-x8t3lf1x 141 4 occurred occur VBD cord-016652-x8t3lf1x 141 5 in in IN cord-016652-x8t3lf1x 141 6 the the DT cord-016652-x8t3lf1x 141 7 mutated mutate VBN cord-016652-x8t3lf1x 141 8 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 141 9 gene gene NN cord-016652-x8t3lf1x 141 10 sequence sequence NN cord-016652-x8t3lf1x 141 11 and and CC cord-016652-x8t3lf1x 141 12 although although IN cord-016652-x8t3lf1x 141 13 the the DT cord-016652-x8t3lf1x 141 14 amino amino NN cord-016652-x8t3lf1x 141 15 acid acid NN cord-016652-x8t3lf1x 141 16 sequence sequence NN cord-016652-x8t3lf1x 141 17 of of IN cord-016652-x8t3lf1x 141 18 the the DT cord-016652-x8t3lf1x 141 19 pat7 pat7 JJ cord-016652-x8t3lf1x 141 20 motif motif NN cord-016652-x8t3lf1x 141 21 was be VBD cord-016652-x8t3lf1x 141 22 altered alter VBN cord-016652-x8t3lf1x 141 23 , , , cord-016652-x8t3lf1x 141 24 its -PRON- PRP$ cord-016652-x8t3lf1x 141 25 function function NN cord-016652-x8t3lf1x 141 26 was be VBD cord-016652-x8t3lf1x 141 27 not not RB cord-016652-x8t3lf1x 141 28 ; ; : cord-016652-x8t3lf1x 141 29 this this DT cord-016652-x8t3lf1x 141 30 new new JJ cord-016652-x8t3lf1x 141 31 signal signal NN cord-016652-x8t3lf1x 141 32 was be VBD cord-016652-x8t3lf1x 141 33 defined define VBN cord-016652-x8t3lf1x 141 34 as as IN cord-016652-x8t3lf1x 141 35 a a DT cord-016652-x8t3lf1x 141 36 pat8 pat8 JJ cord-016652-x8t3lf1x 141 37 motif motif NN cord-016652-x8t3lf1x 141 38 ( ( -LRB- cord-016652-x8t3lf1x 141 39 Lee Lee NNP cord-016652-x8t3lf1x 141 40 et et NNP cord-016652-x8t3lf1x 141 41 al al NNP cord-016652-x8t3lf1x 141 42 . . . cord-016652-x8t3lf1x 141 43 2006 2006 CD cord-016652-x8t3lf1x 141 44 ) ) -RRB- cord-016652-x8t3lf1x 141 45 . . . cord-016652-x8t3lf1x 142 1 The the DT cord-016652-x8t3lf1x 142 2 clear clear JJ cord-016652-x8t3lf1x 142 3 implications implication NNS cord-016652-x8t3lf1x 142 4 of of IN cord-016652-x8t3lf1x 142 5 this this DT cord-016652-x8t3lf1x 142 6 groundbreaking groundbreaking JJ cord-016652-x8t3lf1x 142 7 work work NN cord-016652-x8t3lf1x 142 8 is be VBZ cord-016652-x8t3lf1x 142 9 that that IN cord-016652-x8t3lf1x 142 10 disruption disruption NN cord-016652-x8t3lf1x 142 11 of of IN cord-016652-x8t3lf1x 142 12 nucleolar nucleolar JJ cord-016652-x8t3lf1x 142 13 trafficking trafficking NN cord-016652-x8t3lf1x 142 14 of of IN cord-016652-x8t3lf1x 142 15 a a DT cord-016652-x8t3lf1x 142 16 viral viral JJ cord-016652-x8t3lf1x 142 17 protein protein NN cord-016652-x8t3lf1x 142 18 proves prove VBZ cord-016652-x8t3lf1x 142 19 functional functional JJ cord-016652-x8t3lf1x 142 20 relevance relevance NN cord-016652-x8t3lf1x 142 21 and and CC cord-016652-x8t3lf1x 142 22 illustrates illustrate VBZ cord-016652-x8t3lf1x 142 23 the the DT cord-016652-x8t3lf1x 142 24 potential potential NN cord-016652-x8t3lf1x 142 25 of of IN cord-016652-x8t3lf1x 142 26 exploiting exploit VBG cord-016652-x8t3lf1x 142 27 this this DT cord-016652-x8t3lf1x 142 28 knowledge knowledge NN cord-016652-x8t3lf1x 142 29 for for IN cord-016652-x8t3lf1x 142 30 the the DT cord-016652-x8t3lf1x 142 31 generation generation NN cord-016652-x8t3lf1x 142 32 of of IN cord-016652-x8t3lf1x 142 33 growth growth NN cord-016652-x8t3lf1x 142 34 attenuated attenuate VBN cord-016652-x8t3lf1x 142 35 recombinant recombinant JJ cord-016652-x8t3lf1x 142 36 vaccines vaccine NNS cord-016652-x8t3lf1x 142 37 ( ( -LRB- cord-016652-x8t3lf1x 142 38 Pei Pei NNP cord-016652-x8t3lf1x 142 39 et et NNP cord-016652-x8t3lf1x 142 40 al al NNP cord-016652-x8t3lf1x 142 41 . . NNP cord-016652-x8t3lf1x 142 42 2008 2008 CD cord-016652-x8t3lf1x 142 43 ; ; : cord-016652-x8t3lf1x 142 44 Reed Reed NNP cord-016652-x8t3lf1x 142 45 et et FW cord-016652-x8t3lf1x 142 46 al al NNP cord-016652-x8t3lf1x 142 47 . . . cord-016652-x8t3lf1x 143 1 2006 2006 CD cord-016652-x8t3lf1x 144 1 Reed Reed NNP cord-016652-x8t3lf1x 144 2 et et FW cord-016652-x8t3lf1x 144 3 al al NNP cord-016652-x8t3lf1x 144 4 . . NNP cord-016652-x8t3lf1x 144 5 , , , cord-016652-x8t3lf1x 144 6 2007 2007 CD cord-016652-x8t3lf1x 144 7 . . . cord-016652-x8t3lf1x 145 1 Similarly similarly RB cord-016652-x8t3lf1x 145 2 , , , cord-016652-x8t3lf1x 145 3 point point NN cord-016652-x8t3lf1x 145 4 mutations mutation NNS cord-016652-x8t3lf1x 145 5 in in IN cord-016652-x8t3lf1x 145 6 the the DT cord-016652-x8t3lf1x 145 7 Japanese japanese JJ cord-016652-x8t3lf1x 145 8 encephalitis encephalitis NN cord-016652-x8t3lf1x 145 9 virus virus NN cord-016652-x8t3lf1x 145 10 ( ( -LRB- cord-016652-x8t3lf1x 145 11 JEV JEV NNP cord-016652-x8t3lf1x 145 12 ) ) -RRB- cord-016652-x8t3lf1x 145 13 core core NN cord-016652-x8t3lf1x 145 14 protein protein NN cord-016652-x8t3lf1x 145 15 that that WDT cord-016652-x8t3lf1x 145 16 abolished abolish VBD cord-016652-x8t3lf1x 145 17 nuclear nuclear JJ cord-016652-x8t3lf1x 145 18 and and CC cord-016652-x8t3lf1x 145 19 nucleolar nucleolar JJ cord-016652-x8t3lf1x 145 20 localisation localisation NN cord-016652-x8t3lf1x 145 21 resulted result VBD cord-016652-x8t3lf1x 145 22 in in IN cord-016652-x8t3lf1x 145 23 recombinant recombinant JJ cord-016652-x8t3lf1x 145 24 viruses virus NNS cord-016652-x8t3lf1x 145 25 with with IN cord-016652-x8t3lf1x 145 26 impaired impaired JJ cord-016652-x8t3lf1x 145 27 replication replication NN cord-016652-x8t3lf1x 145 28 in in IN cord-016652-x8t3lf1x 145 29 mammalian mammalian JJ cord-016652-x8t3lf1x 145 30 cells cell NNS cord-016652-x8t3lf1x 145 31 , , , cord-016652-x8t3lf1x 145 32 compared compare VBN cord-016652-x8t3lf1x 145 33 to to IN cord-016652-x8t3lf1x 145 34 wild wild JJ cord-016652-x8t3lf1x 145 35 type type NN cord-016652-x8t3lf1x 145 36 virus virus NN cord-016652-x8t3lf1x 145 37 ( ( -LRB- cord-016652-x8t3lf1x 145 38 Mori Mori NNP cord-016652-x8t3lf1x 145 39 et et FW cord-016652-x8t3lf1x 145 40 al al NNP cord-016652-x8t3lf1x 145 41 . . NNP cord-016652-x8t3lf1x 145 42 2005 2005 CD cord-016652-x8t3lf1x 145 43 ; ; . cord-016652-x8t3lf1x 146 1 Tsuda Tsuda NNP cord-016652-x8t3lf1x 146 2 et et FW cord-016652-x8t3lf1x 146 3 al al NNP cord-016652-x8t3lf1x 146 4 . . . cord-016652-x8t3lf1x 146 5 2006 2006 CD cord-016652-x8t3lf1x 146 6 ) ) -RRB- cord-016652-x8t3lf1x 146 7 . . . cord-016652-x8t3lf1x 147 1 Curiously curiously RB cord-016652-x8t3lf1x 147 2 , , , cord-016652-x8t3lf1x 147 3 replication replication NN cord-016652-x8t3lf1x 147 4 of of IN cord-016652-x8t3lf1x 147 5 recombinant recombinant JJ cord-016652-x8t3lf1x 147 6 viruses virus NNS cord-016652-x8t3lf1x 147 7 was be VBD cord-016652-x8t3lf1x 147 8 not not RB cord-016652-x8t3lf1x 147 9 impaired impair VBN cord-016652-x8t3lf1x 147 10 in in IN cord-016652-x8t3lf1x 147 11 insect insect NN cord-016652-x8t3lf1x 147 12 cells cell NNS cord-016652-x8t3lf1x 147 13 , , , cord-016652-x8t3lf1x 147 14 illustrating illustrate VBG cord-016652-x8t3lf1x 147 15 this this DT cord-016652-x8t3lf1x 147 16 could could MD cord-016652-x8t3lf1x 147 17 potentially potentially RB cord-016652-x8t3lf1x 147 18 be be VB cord-016652-x8t3lf1x 147 19 related relate VBN cord-016652-x8t3lf1x 147 20 to to IN cord-016652-x8t3lf1x 147 21 differences difference NNS cord-016652-x8t3lf1x 147 22 in in IN cord-016652-x8t3lf1x 147 23 nucleolar nucleolar JJ cord-016652-x8t3lf1x 147 24 architecture architecture NN cord-016652-x8t3lf1x 147 25 and and CC cord-016652-x8t3lf1x 147 26 proteomes proteome NNS cord-016652-x8t3lf1x 147 27 between between IN cord-016652-x8t3lf1x 147 28 these these DT cord-016652-x8t3lf1x 147 29 cell cell NN cord-016652-x8t3lf1x 147 30 types type NNS cord-016652-x8t3lf1x 147 31 ( ( -LRB- cord-016652-x8t3lf1x 147 32 Thiry Thiry NNP cord-016652-x8t3lf1x 147 33 and and CC cord-016652-x8t3lf1x 147 34 Lafontaine Lafontaine NNP cord-016652-x8t3lf1x 147 35 2005 2005 CD cord-016652-x8t3lf1x 147 36 ) ) -RRB- cord-016652-x8t3lf1x 147 37 . . . cord-016652-x8t3lf1x 148 1 The the DT cord-016652-x8t3lf1x 148 2 JEV JEV NNP cord-016652-x8t3lf1x 148 3 core core NN cord-016652-x8t3lf1x 148 4 protein protein NN cord-016652-x8t3lf1x 148 5 has have VBZ cord-016652-x8t3lf1x 148 6 been be VBN cord-016652-x8t3lf1x 148 7 shown show VBN cord-016652-x8t3lf1x 148 8 to to TO cord-016652-x8t3lf1x 148 9 interact interact VB cord-016652-x8t3lf1x 148 10 with with IN cord-016652-x8t3lf1x 148 11 nucleophosmin nucleophosmin NNP cord-016652-x8t3lf1x 148 12 and and CC cord-016652-x8t3lf1x 148 13 is be VBZ cord-016652-x8t3lf1x 148 14 translocated translocate VBN cord-016652-x8t3lf1x 148 15 from from IN cord-016652-x8t3lf1x 148 16 the the DT cord-016652-x8t3lf1x 148 17 nucleolus nucleolus NN cord-016652-x8t3lf1x 148 18 to to IN cord-016652-x8t3lf1x 148 19 the the DT cord-016652-x8t3lf1x 148 20 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 148 21 . . . cord-016652-x8t3lf1x 149 1 Flaviviruses flavivirus NNS cord-016652-x8t3lf1x 149 2 in in IN cord-016652-x8t3lf1x 149 3 general general JJ cord-016652-x8t3lf1x 149 4 ( ( -LRB- cord-016652-x8t3lf1x 149 5 JEV JEV NNP cord-016652-x8t3lf1x 149 6 , , , cord-016652-x8t3lf1x 149 7 Dengue Dengue NNP cord-016652-x8t3lf1x 149 8 virus virus NN cord-016652-x8t3lf1x 149 9 and and CC cord-016652-x8t3lf1x 149 10 West West NNP cord-016652-x8t3lf1x 149 11 Nile Nile NNP cord-016652-x8t3lf1x 149 12 virus virus NN cord-016652-x8t3lf1x 149 13 ) ) -RRB- cord-016652-x8t3lf1x 149 14 appear appear VBP cord-016652-x8t3lf1x 149 15 to to TO cord-016652-x8t3lf1x 149 16 have have VB cord-016652-x8t3lf1x 149 17 a a DT cord-016652-x8t3lf1x 149 18 part part JJ cord-016652-x8t3lf1x 149 19 - - HYPH cord-016652-x8t3lf1x 149 20 nuclear nuclear JJ cord-016652-x8t3lf1x 149 21 stage stage NN cord-016652-x8t3lf1x 149 22 to to IN cord-016652-x8t3lf1x 149 23 the the DT cord-016652-x8t3lf1x 149 24 synthesis synthesis NN cord-016652-x8t3lf1x 149 25 of of IN cord-016652-x8t3lf1x 149 26 viral viral JJ cord-016652-x8t3lf1x 149 27 RNA RNA NNP cord-016652-x8t3lf1x 149 28 and and CC cord-016652-x8t3lf1x 149 29 several several JJ cord-016652-x8t3lf1x 149 30 components component NNS cord-016652-x8t3lf1x 149 31 of of IN cord-016652-x8t3lf1x 149 32 the the DT cord-016652-x8t3lf1x 149 33 viral viral JJ cord-016652-x8t3lf1x 149 34 replicase replicase NN cord-016652-x8t3lf1x 149 35 together together RB cord-016652-x8t3lf1x 149 36 with with IN cord-016652-x8t3lf1x 149 37 newly newly RB cord-016652-x8t3lf1x 149 38 synthesised synthesise VBN cord-016652-x8t3lf1x 149 39 RNA RNA NNP cord-016652-x8t3lf1x 149 40 have have VBP cord-016652-x8t3lf1x 149 41 been be VBN cord-016652-x8t3lf1x 149 42 found find VBN cord-016652-x8t3lf1x 149 43 in in IN cord-016652-x8t3lf1x 149 44 the the DT cord-016652-x8t3lf1x 149 45 nucleus nucleus NN cord-016652-x8t3lf1x 149 46 of of IN cord-016652-x8t3lf1x 149 47 infected infected JJ cord-016652-x8t3lf1x 149 48 cells cell NNS cord-016652-x8t3lf1x 150 1 ( ( -LRB- cord-016652-x8t3lf1x 150 2 Uchil Uchil NNP cord-016652-x8t3lf1x 150 3 et et NNP cord-016652-x8t3lf1x 150 4 al al NNP cord-016652-x8t3lf1x 150 5 . . . cord-016652-x8t3lf1x 150 6 2006 2006 CD cord-016652-x8t3lf1x 150 7 ) ) -RRB- cord-016652-x8t3lf1x 150 8 . . . cord-016652-x8t3lf1x 151 1 One one CD cord-016652-x8t3lf1x 151 2 intriguing intriguing JJ cord-016652-x8t3lf1x 151 3 question question NN cord-016652-x8t3lf1x 151 4 that that WDT cord-016652-x8t3lf1x 151 5 has have VBZ cord-016652-x8t3lf1x 151 6 yet yet RB cord-016652-x8t3lf1x 151 7 to to TO cord-016652-x8t3lf1x 151 8 be be VB cord-016652-x8t3lf1x 151 9 elucidated elucidate VBN cord-016652-x8t3lf1x 151 10 is be VBZ cord-016652-x8t3lf1x 151 11 how how WRB cord-016652-x8t3lf1x 151 12 such such JJ cord-016652-x8t3lf1x 151 13 viral viral JJ cord-016652-x8t3lf1x 151 14 RNA RNA NNP cord-016652-x8t3lf1x 151 15 traffics traffic NNS cord-016652-x8t3lf1x 151 16 from from IN cord-016652-x8t3lf1x 151 17 the the DT cord-016652-x8t3lf1x 151 18 nucleus nucleus NN cord-016652-x8t3lf1x 151 19 to to IN cord-016652-x8t3lf1x 151 20 the the DT cord-016652-x8t3lf1x 151 21 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 151 22 . . . cord-016652-x8t3lf1x 152 1 Most Most JJS cord-016652-x8t3lf1x 152 2 cellular cellular JJ cord-016652-x8t3lf1x 152 3 mRNAs mrna NNS cord-016652-x8t3lf1x 152 4 are be VBP cord-016652-x8t3lf1x 152 5 spliced splice VBN cord-016652-x8t3lf1x 152 6 and and CC cord-016652-x8t3lf1x 152 7 it -PRON- PRP cord-016652-x8t3lf1x 152 8 is be VBZ cord-016652-x8t3lf1x 152 9 part part NN cord-016652-x8t3lf1x 152 10 of of IN cord-016652-x8t3lf1x 152 11 the the DT cord-016652-x8t3lf1x 152 12 splicing splicing NN cord-016652-x8t3lf1x 152 13 process process NN cord-016652-x8t3lf1x 152 14 that that WDT cord-016652-x8t3lf1x 152 15 signals signal VBZ cord-016652-x8t3lf1x 152 16 nuclear nuclear JJ cord-016652-x8t3lf1x 152 17 export export NN cord-016652-x8t3lf1x 152 18 . . . cord-016652-x8t3lf1x 153 1 Certain certain JJ cord-016652-x8t3lf1x 153 2 DNA dna NN cord-016652-x8t3lf1x 153 3 viruses virus NNS cord-016652-x8t3lf1x 153 4 , , , cord-016652-x8t3lf1x 153 5 such such JJ cord-016652-x8t3lf1x 153 6 as as IN cord-016652-x8t3lf1x 153 7 herpesvirus herpesvirus NNP cord-016652-x8t3lf1x 153 8 saimiri saimiri NNP cord-016652-x8t3lf1x 153 9 , , , cord-016652-x8t3lf1x 153 10 produce produce VB cord-016652-x8t3lf1x 153 11 intron intron NN cord-016652-x8t3lf1x 153 12 - - HYPH cord-016652-x8t3lf1x 153 13 less less JJR cord-016652-x8t3lf1x 153 14 mRNA mrna NN cord-016652-x8t3lf1x 154 1 and and CC cord-016652-x8t3lf1x 154 2 these these DT cord-016652-x8t3lf1x 154 3 viruses virus NNS cord-016652-x8t3lf1x 154 4 have have VBP cord-016652-x8t3lf1x 154 5 evolved evolve VBN cord-016652-x8t3lf1x 154 6 specific specific JJ cord-016652-x8t3lf1x 154 7 viral viral JJ cord-016652-x8t3lf1x 154 8 proteins protein NNS cord-016652-x8t3lf1x 154 9 ( ( -LRB- cord-016652-x8t3lf1x 154 10 such such JJ cord-016652-x8t3lf1x 154 11 as as IN cord-016652-x8t3lf1x 154 12 herpesvirus herpesvirus NNP cord-016652-x8t3lf1x 154 13 saimiri saimiri NNP cord-016652-x8t3lf1x 155 1 ORF57 ORF57 NNP cord-016652-x8t3lf1x 156 1 ( ( -LRB- cord-016652-x8t3lf1x 156 2 Boyne Boyne NNP cord-016652-x8t3lf1x 156 3 et et NNP cord-016652-x8t3lf1x 156 4 al al NNP cord-016652-x8t3lf1x 156 5 . . NNP cord-016652-x8t3lf1x 156 6 2008a 2008a CD cord-016652-x8t3lf1x 156 7 ) ) -RRB- cord-016652-x8t3lf1x 156 8 ) ) -RRB- cord-016652-x8t3lf1x 156 9 , , , cord-016652-x8t3lf1x 156 10 which which WDT cord-016652-x8t3lf1x 156 11 interact interact VBP cord-016652-x8t3lf1x 156 12 with with IN cord-016652-x8t3lf1x 156 13 the the DT cord-016652-x8t3lf1x 156 14 cellular cellular JJ cord-016652-x8t3lf1x 156 15 mRNA mRNA NNP cord-016652-x8t3lf1x 156 16 export export NN cord-016652-x8t3lf1x 156 17 machinery machinery NN cord-016652-x8t3lf1x 156 18 ( ( -LRB- cord-016652-x8t3lf1x 156 19 e.g. e.g. RB cord-016652-x8t3lf1x 156 20 the the DT cord-016652-x8t3lf1x 156 21 mRNA mRNA NNP cord-016652-x8t3lf1x 156 22 processing processing NN cord-016652-x8t3lf1x 156 23 and and CC cord-016652-x8t3lf1x 156 24 export export NN cord-016652-x8t3lf1x 156 25 factor factor NN cord-016652-x8t3lf1x 156 26 ALY ALY NNP cord-016652-x8t3lf1x 156 27 ) ) -RRB- cord-016652-x8t3lf1x 156 28 to to TO cord-016652-x8t3lf1x 156 29 traffic traffic NN cord-016652-x8t3lf1x 156 30 viral viral JJ cord-016652-x8t3lf1x 157 1 mRNA mrna NN cord-016652-x8t3lf1x 157 2 from from IN cord-016652-x8t3lf1x 157 3 the the DT cord-016652-x8t3lf1x 157 4 nucleus nucleus NN cord-016652-x8t3lf1x 157 5 to to IN cord-016652-x8t3lf1x 157 6 the the DT cord-016652-x8t3lf1x 157 7 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 158 1 ( ( -LRB- cord-016652-x8t3lf1x 158 2 Boyne Boyne NNP cord-016652-x8t3lf1x 158 3 et et NNP cord-016652-x8t3lf1x 158 4 al al NNP cord-016652-x8t3lf1x 158 5 . . . cord-016652-x8t3lf1x 159 1 2008b 2008b CD cord-016652-x8t3lf1x 160 1 ( ( -LRB- cord-016652-x8t3lf1x 160 2 Boyne Boyne NNP cord-016652-x8t3lf1x 160 3 et et NNP cord-016652-x8t3lf1x 160 4 al al NNP cord-016652-x8t3lf1x 160 5 . . NNP cord-016652-x8t3lf1x 160 6 , , , cord-016652-x8t3lf1x 160 7 2010 2010 CD cord-016652-x8t3lf1x 160 8 Boyne Boyne NNP cord-016652-x8t3lf1x 160 9 and and CC cord-016652-x8t3lf1x 160 10 Whitehouse Whitehouse NNP cord-016652-x8t3lf1x 160 11 2006 2006 CD cord-016652-x8t3lf1x 160 12 ) ) -RRB- cord-016652-x8t3lf1x 160 13 and and CC cord-016652-x8t3lf1x 160 14 a a DT cord-016652-x8t3lf1x 160 15 similar similar JJ cord-016652-x8t3lf1x 160 16 process process NN cord-016652-x8t3lf1x 160 17 might may MD cord-016652-x8t3lf1x 160 18 be be VB cord-016652-x8t3lf1x 160 19 required require VBN cord-016652-x8t3lf1x 160 20 by by IN cord-016652-x8t3lf1x 160 21 RNA RNA NNP cord-016652-x8t3lf1x 160 22 viruses virus NNS cord-016652-x8t3lf1x 160 23 . . . cord-016652-x8t3lf1x 161 1 For for IN cord-016652-x8t3lf1x 161 2 example example NN cord-016652-x8t3lf1x 161 3 , , , cord-016652-x8t3lf1x 161 4 tomato tomato NN cord-016652-x8t3lf1x 161 5 bushy bushy JJ cord-016652-x8t3lf1x 161 6 stunt stunt NN cord-016652-x8t3lf1x 161 7 virus virus NN cord-016652-x8t3lf1x 161 8 ( ( -LRB- cord-016652-x8t3lf1x 161 9 TBSV TBSV NNP cord-016652-x8t3lf1x 161 10 ) ) -RRB- cord-016652-x8t3lf1x 161 11 redistributes redistribute VBZ cord-016652-x8t3lf1x 161 12 ALY ALY NNP cord-016652-x8t3lf1x 161 13 from from IN cord-016652-x8t3lf1x 161 14 the the DT cord-016652-x8t3lf1x 161 15 nucleus nucleus NN cord-016652-x8t3lf1x 161 16 to to IN cord-016652-x8t3lf1x 161 17 the the DT cord-016652-x8t3lf1x 161 18 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 161 19 , , , cord-016652-x8t3lf1x 161 20 and and CC cord-016652-x8t3lf1x 161 21 this this DT cord-016652-x8t3lf1x 161 22 might may MD cord-016652-x8t3lf1x 161 23 be be VB cord-016652-x8t3lf1x 161 24 a a DT cord-016652-x8t3lf1x 161 25 way way NN cord-016652-x8t3lf1x 161 26 the the DT cord-016652-x8t3lf1x 161 27 virus virus NN cord-016652-x8t3lf1x 161 28 mediates mediate VBZ cord-016652-x8t3lf1x 161 29 host host NN cord-016652-x8t3lf1x 161 30 cell cell NN cord-016652-x8t3lf1x 161 31 protein protein NN cord-016652-x8t3lf1x 161 32 synthesis synthesis NN cord-016652-x8t3lf1x 161 33 ( ( -LRB- cord-016652-x8t3lf1x 161 34 Uhrig Uhrig NNP cord-016652-x8t3lf1x 161 35 et et NNP cord-016652-x8t3lf1x 161 36 al al NNP cord-016652-x8t3lf1x 161 37 . . . cord-016652-x8t3lf1x 161 38 2004 2004 CD cord-016652-x8t3lf1x 161 39 ) ) -RRB- cord-016652-x8t3lf1x 161 40 . . . cord-016652-x8t3lf1x 162 1 In in IN cord-016652-x8t3lf1x 162 2 plants plant NNS cord-016652-x8t3lf1x 162 3 RNA RNA NNP cord-016652-x8t3lf1x 162 4 silencing silencing NN cord-016652-x8t3lf1x 162 5 , , , cord-016652-x8t3lf1x 163 1 a a DT cord-016652-x8t3lf1x 163 2 host host NN cord-016652-x8t3lf1x 163 3 defence defence NN cord-016652-x8t3lf1x 163 4 mechanism mechanism NN cord-016652-x8t3lf1x 163 5 targets target VBZ cord-016652-x8t3lf1x 163 6 virus virus NN cord-016652-x8t3lf1x 163 7 RNAs rna NNS cord-016652-x8t3lf1x 163 8 for for IN cord-016652-x8t3lf1x 163 9 degradation degradation NN cord-016652-x8t3lf1x 163 10 in in IN cord-016652-x8t3lf1x 163 11 a a DT cord-016652-x8t3lf1x 163 12 sequence sequence NN cord-016652-x8t3lf1x 163 13 - - HYPH cord-016652-x8t3lf1x 163 14 specific specific JJ cord-016652-x8t3lf1x 163 15 manner manner NN cord-016652-x8t3lf1x 163 16 and and CC cord-016652-x8t3lf1x 163 17 viruses virus NNS cord-016652-x8t3lf1x 163 18 use use VBP cord-016652-x8t3lf1x 163 19 several several JJ cord-016652-x8t3lf1x 163 20 mechanisms mechanism NNS cord-016652-x8t3lf1x 163 21 to to TO cord-016652-x8t3lf1x 163 22 counteract counteract VB cord-016652-x8t3lf1x 163 23 this this DT cord-016652-x8t3lf1x 163 24 system system NN cord-016652-x8t3lf1x 163 25 ( ( -LRB- cord-016652-x8t3lf1x 163 26 Canto Canto NNP cord-016652-x8t3lf1x 163 27 et et FW cord-016652-x8t3lf1x 163 28 al al NNP cord-016652-x8t3lf1x 163 29 . . . cord-016652-x8t3lf1x 163 30 2006 2006 CD cord-016652-x8t3lf1x 163 31 ) ) -RRB- cord-016652-x8t3lf1x 163 32 . . . cord-016652-x8t3lf1x 164 1 TBSV TBSV NNP cord-016652-x8t3lf1x 164 2 encodes encode VBZ cord-016652-x8t3lf1x 164 3 a a DT cord-016652-x8t3lf1x 164 4 protein protein NN cord-016652-x8t3lf1x 164 5 , , , cord-016652-x8t3lf1x 164 6 P19 P19 NNP cord-016652-x8t3lf1x 164 7 , , , cord-016652-x8t3lf1x 164 8 which which WDT cord-016652-x8t3lf1x 164 9 interferes interfere VBZ cord-016652-x8t3lf1x 164 10 with with IN cord-016652-x8t3lf1x 164 11 this this DT cord-016652-x8t3lf1x 164 12 pathway pathway NN cord-016652-x8t3lf1x 164 13 . . . cord-016652-x8t3lf1x 165 1 However however RB cord-016652-x8t3lf1x 165 2 , , , cord-016652-x8t3lf1x 165 3 ALY ALY NNP cord-016652-x8t3lf1x 165 4 might may MD cord-016652-x8t3lf1x 165 5 transport transport VB cord-016652-x8t3lf1x 165 6 P19 P19 NNP cord-016652-x8t3lf1x 165 7 from from IN cord-016652-x8t3lf1x 165 8 the the DT cord-016652-x8t3lf1x 165 9 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 165 10 to to IN cord-016652-x8t3lf1x 165 11 the the DT cord-016652-x8t3lf1x 165 12 nucleus nucleus NN cord-016652-x8t3lf1x 165 13 or or CC cord-016652-x8t3lf1x 165 14 nucleolus nucleolus NN cord-016652-x8t3lf1x 165 15 and and CC cord-016652-x8t3lf1x 165 16 disrupt disrupt VB cord-016652-x8t3lf1x 165 17 its -PRON- PRP$ cord-016652-x8t3lf1x 165 18 silencing silence VBG cord-016652-x8t3lf1x 165 19 suppression suppression NN cord-016652-x8t3lf1x 165 20 activity activity NN cord-016652-x8t3lf1x 165 21 . . . cord-016652-x8t3lf1x 166 1 Nucleolin Nucleolin NNP cord-016652-x8t3lf1x 166 2 has have VBZ cord-016652-x8t3lf1x 166 3 also also RB cord-016652-x8t3lf1x 166 4 been be VBN cord-016652-x8t3lf1x 166 5 shown show VBN cord-016652-x8t3lf1x 166 6 to to TO cord-016652-x8t3lf1x 166 7 be be VB cord-016652-x8t3lf1x 166 8 involved involve VBN cord-016652-x8t3lf1x 166 9 in in IN cord-016652-x8t3lf1x 166 10 the the DT cord-016652-x8t3lf1x 166 11 trafficking trafficking NN cord-016652-x8t3lf1x 166 12 of of IN cord-016652-x8t3lf1x 166 13 herpes herpes NNP cord-016652-x8t3lf1x 166 14 simplex simplex NNP cord-016652-x8t3lf1x 166 15 virus virus NN cord-016652-x8t3lf1x 166 16 type type NN cord-016652-x8t3lf1x 166 17 1 1 CD cord-016652-x8t3lf1x 166 18 nucleocapsids nucleocapsid NNS cord-016652-x8t3lf1x 166 19 from from IN cord-016652-x8t3lf1x 166 20 the the DT cord-016652-x8t3lf1x 166 21 nucleus nucleus NN cord-016652-x8t3lf1x 166 22 to to IN cord-016652-x8t3lf1x 166 23 the the DT cord-016652-x8t3lf1x 166 24 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 167 1 ( ( -LRB- cord-016652-x8t3lf1x 167 2 Sagou Sagou NNP cord-016652-x8t3lf1x 167 3 et et NNP cord-016652-x8t3lf1x 167 4 al al NNP cord-016652-x8t3lf1x 167 5 . . NNP cord-016652-x8t3lf1x 167 6 2010 2010 CD cord-016652-x8t3lf1x 167 7 ) ) -RRB- cord-016652-x8t3lf1x 167 8 , , , cord-016652-x8t3lf1x 167 9 drawing draw VBG cord-016652-x8t3lf1x 167 10 parallels parallel NNS cord-016652-x8t3lf1x 167 11 with with IN cord-016652-x8t3lf1x 167 12 the the DT cord-016652-x8t3lf1x 167 13 involvement involvement NN cord-016652-x8t3lf1x 167 14 of of IN cord-016652-x8t3lf1x 167 15 nucleolar nucleolar JJ cord-016652-x8t3lf1x 167 16 proteins protein NNS cord-016652-x8t3lf1x 167 17 in in IN cord-016652-x8t3lf1x 167 18 the the DT cord-016652-x8t3lf1x 167 19 movement movement NN cord-016652-x8t3lf1x 167 20 of of IN cord-016652-x8t3lf1x 167 21 plant plant NN cord-016652-x8t3lf1x 167 22 viruses virus NNS cord-016652-x8t3lf1x 168 1 ( ( -LRB- cord-016652-x8t3lf1x 168 2 Kim Kim NNP cord-016652-x8t3lf1x 168 3 et et NNP cord-016652-x8t3lf1x 168 4 al al NNP cord-016652-x8t3lf1x 168 5 . . . cord-016652-x8t3lf1x 169 1 2007a 2007a CD cord-016652-x8t3lf1x 169 2 , , , cord-016652-x8t3lf1x 169 3 b b LS cord-016652-x8t3lf1x 169 4 ) ) -RRB- cord-016652-x8t3lf1x 169 5 . . . cord-016652-x8t3lf1x 170 1 Different different JJ cord-016652-x8t3lf1x 170 2 plant plant NN cord-016652-x8t3lf1x 170 3 virus virus NN cord-016652-x8t3lf1x 170 4 proteins protein NNS cord-016652-x8t3lf1x 170 5 involved involve VBN cord-016652-x8t3lf1x 170 6 in in IN cord-016652-x8t3lf1x 170 7 long long JJ cord-016652-x8t3lf1x 170 8 - - HYPH cord-016652-x8t3lf1x 170 9 distance distance NN cord-016652-x8t3lf1x 170 10 phloem phloem NNS cord-016652-x8t3lf1x 170 11 - - HYPH cord-016652-x8t3lf1x 170 12 associated associate VBN cord-016652-x8t3lf1x 170 13 movement movement NN cord-016652-x8t3lf1x 170 14 of of IN cord-016652-x8t3lf1x 170 15 virus virus NN cord-016652-x8t3lf1x 170 16 particles particle NNS cord-016652-x8t3lf1x 170 17 or or CC cord-016652-x8t3lf1x 170 18 with with IN cord-016652-x8t3lf1x 170 19 roles role NNS cord-016652-x8t3lf1x 170 20 in in IN cord-016652-x8t3lf1x 170 21 binding bind VBG cord-016652-x8t3lf1x 170 22 to to IN cord-016652-x8t3lf1x 170 23 the the DT cord-016652-x8t3lf1x 170 24 RNA RNA NNP cord-016652-x8t3lf1x 170 25 virus virus NN cord-016652-x8t3lf1x 170 26 genomes genome NNS cord-016652-x8t3lf1x 170 27 localise localise VBP cord-016652-x8t3lf1x 170 28 to to IN cord-016652-x8t3lf1x 170 29 the the DT cord-016652-x8t3lf1x 170 30 nucleolus nucleolus NN cord-016652-x8t3lf1x 170 31 and and CC cord-016652-x8t3lf1x 170 32 other other JJ cord-016652-x8t3lf1x 170 33 sub sub JJ cord-016652-x8t3lf1x 170 34 - - JJ cord-016652-x8t3lf1x 170 35 nuclear nuclear JJ cord-016652-x8t3lf1x 170 36 structures structure NNS cord-016652-x8t3lf1x 171 1 ( ( -LRB- cord-016652-x8t3lf1x 171 2 Kim Kim NNP cord-016652-x8t3lf1x 171 3 et et NNP cord-016652-x8t3lf1x 171 4 al al NNP cord-016652-x8t3lf1x 171 5 . . . cord-016652-x8t3lf1x 172 1 2007b 2007b CD cord-016652-x8t3lf1x 172 2 ; ; : cord-016652-x8t3lf1x 172 3 Ryabov Ryabov NNP cord-016652-x8t3lf1x 172 4 et et NNP cord-016652-x8t3lf1x 172 5 al al NNP cord-016652-x8t3lf1x 172 6 . . . cord-016652-x8t3lf1x 172 7 2004 2004 CD cord-016652-x8t3lf1x 172 8 ) ) -RRB- cord-016652-x8t3lf1x 172 9 . . . cord-016652-x8t3lf1x 173 1 This this DT cord-016652-x8t3lf1x 173 2 may may MD cord-016652-x8t3lf1x 173 3 be be VB cord-016652-x8t3lf1x 173 4 mediated mediate VBN cord-016652-x8t3lf1x 173 5 by by IN cord-016652-x8t3lf1x 173 6 association association NN cord-016652-x8t3lf1x 173 7 with with IN cord-016652-x8t3lf1x 173 8 nuclear nuclear JJ cord-016652-x8t3lf1x 173 9 proteins protein NNS cord-016652-x8t3lf1x 173 10 , , , cord-016652-x8t3lf1x 173 11 as as IN cord-016652-x8t3lf1x 173 12 is be VBZ cord-016652-x8t3lf1x 173 13 the the DT cord-016652-x8t3lf1x 173 14 case case NN cord-016652-x8t3lf1x 173 15 with with IN cord-016652-x8t3lf1x 173 16 fibrillarin fibrillarin NNP cord-016652-x8t3lf1x 173 17 and and CC cord-016652-x8t3lf1x 173 18 the the DT cord-016652-x8t3lf1x 173 19 ORF3 ORF3 NNP cord-016652-x8t3lf1x 173 20 protein protein NN cord-016652-x8t3lf1x 173 21 of of IN cord-016652-x8t3lf1x 173 22 plant plant NN cord-016652-x8t3lf1x 173 23 umbraviruses umbraviruse NNS cord-016652-x8t3lf1x 174 1 ( ( -LRB- cord-016652-x8t3lf1x 174 2 Kim Kim NNP cord-016652-x8t3lf1x 174 3 et et NNP cord-016652-x8t3lf1x 174 4 al al NNP cord-016652-x8t3lf1x 174 5 . . NNP cord-016652-x8t3lf1x 174 6 2007a 2007a CD cord-016652-x8t3lf1x 174 7 ) ) -RRB- cord-016652-x8t3lf1x 174 8 . . . cord-016652-x8t3lf1x 175 1 Hijacking hijack VBG cord-016652-x8t3lf1x 175 2 the the DT cord-016652-x8t3lf1x 175 3 nucleolus nucleolus NN cord-016652-x8t3lf1x 175 4 is be VBZ cord-016652-x8t3lf1x 175 5 not not RB cord-016652-x8t3lf1x 175 6 exclusive exclusive JJ cord-016652-x8t3lf1x 175 7 to to TO cord-016652-x8t3lf1x 175 8 plant plant NN cord-016652-x8t3lf1x 175 9 viruses virus NNS cord-016652-x8t3lf1x 175 10 and and CC cord-016652-x8t3lf1x 175 11 may may MD cord-016652-x8t3lf1x 175 12 also also RB cord-016652-x8t3lf1x 175 13 occur occur VB cord-016652-x8t3lf1x 175 14 with with IN cord-016652-x8t3lf1x 175 15 mammalian mammalian JJ cord-016652-x8t3lf1x 175 16 viruses virus NNS cord-016652-x8t3lf1x 175 17 . . . cord-016652-x8t3lf1x 176 1 Similar similar JJ cord-016652-x8t3lf1x 176 2 to to IN cord-016652-x8t3lf1x 176 3 the the DT cord-016652-x8t3lf1x 176 4 plant plant NN cord-016652-x8t3lf1x 176 5 rhabdovirus rhabdovirus NNP cord-016652-x8t3lf1x 176 6 maize maize NNP cord-016652-x8t3lf1x 176 7 fine fine JJ cord-016652-x8t3lf1x 176 8 streak streak NN cord-016652-x8t3lf1x 176 9 virus virus NN cord-016652-x8t3lf1x 176 10 ( ( -LRB- cord-016652-x8t3lf1x 176 11 MFSV MFSV NNP cord-016652-x8t3lf1x 176 12 ) ) -RRB- cord-016652-x8t3lf1x 176 13 , , , cord-016652-x8t3lf1x 176 14 whose whose WP$ cord-016652-x8t3lf1x 176 15 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 176 16 and and CC cord-016652-x8t3lf1x 176 17 phosphoproteins phosphoprotein NNS cord-016652-x8t3lf1x 176 18 localise localise VBP cord-016652-x8t3lf1x 176 19 to to IN cord-016652-x8t3lf1x 176 20 the the DT cord-016652-x8t3lf1x 176 21 nucleolus nucleolus NN cord-016652-x8t3lf1x 177 1 ( ( -LRB- cord-016652-x8t3lf1x 177 2 Tsai Tsai NNP cord-016652-x8t3lf1x 177 3 et et NNP cord-016652-x8t3lf1x 177 4 al al NNP cord-016652-x8t3lf1x 177 5 . . NNP cord-016652-x8t3lf1x 177 6 2005 2005 CD cord-016652-x8t3lf1x 177 7 ) ) -RRB- cord-016652-x8t3lf1x 178 1 , , , cord-016652-x8t3lf1x 178 2 the the DT cord-016652-x8t3lf1x 178 3 animal animal NN cord-016652-x8t3lf1x 178 4 negative negative JJ cord-016652-x8t3lf1x 178 5 - - HYPH cord-016652-x8t3lf1x 178 6 stranded strand VBN cord-016652-x8t3lf1x 178 7 RNA RNA NNP cord-016652-x8t3lf1x 178 8 virus virus NN cord-016652-x8t3lf1x 178 9 Borna Borna NNP cord-016652-x8t3lf1x 178 10 disease disease NN cord-016652-x8t3lf1x 178 11 virus virus NN cord-016652-x8t3lf1x 178 12 has have VBZ cord-016652-x8t3lf1x 178 13 been be VBN cord-016652-x8t3lf1x 178 14 reported report VBN cord-016652-x8t3lf1x 178 15 to to TO cord-016652-x8t3lf1x 178 16 use use VB cord-016652-x8t3lf1x 178 17 the the DT cord-016652-x8t3lf1x 178 18 nucleolus nucleolus NN cord-016652-x8t3lf1x 178 19 as as IN cord-016652-x8t3lf1x 178 20 a a DT cord-016652-x8t3lf1x 178 21 site site NN cord-016652-x8t3lf1x 178 22 for for IN cord-016652-x8t3lf1x 178 23 genome genome NN cord-016652-x8t3lf1x 178 24 replication replication NN cord-016652-x8t3lf1x 178 25 , , , cord-016652-x8t3lf1x 178 26 and and CC cord-016652-x8t3lf1x 178 27 its -PRON- PRP$ cord-016652-x8t3lf1x 178 28 RNA RNA NNP cord-016652-x8t3lf1x 178 29 - - HYPH cord-016652-x8t3lf1x 178 30 binding bind VBG cord-016652-x8t3lf1x 178 31 protein protein NN cord-016652-x8t3lf1x 178 32 has have VBZ cord-016652-x8t3lf1x 178 33 the the DT cord-016652-x8t3lf1x 178 34 appropriate appropriate JJ cord-016652-x8t3lf1x 178 35 trafficking trafficking NN cord-016652-x8t3lf1x 178 36 signals signal NNS cord-016652-x8t3lf1x 178 37 for for IN cord-016652-x8t3lf1x 178 38 import import NN cord-016652-x8t3lf1x 178 39 to to IN cord-016652-x8t3lf1x 178 40 and and CC cord-016652-x8t3lf1x 178 41 export export NN cord-016652-x8t3lf1x 178 42 from from IN cord-016652-x8t3lf1x 178 43 the the DT cord-016652-x8t3lf1x 178 44 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 178 45 to to IN cord-016652-x8t3lf1x 178 46 the the DT cord-016652-x8t3lf1x 178 47 nucleus nucleus NN cord-016652-x8t3lf1x 179 1 ( ( -LRB- cord-016652-x8t3lf1x 179 2 Pyper Pyper NNP cord-016652-x8t3lf1x 179 3 et et FW cord-016652-x8t3lf1x 179 4 al al NNP cord-016652-x8t3lf1x 179 5 . . NNP cord-016652-x8t3lf1x 179 6 1998 1998 CD cord-016652-x8t3lf1x 179 7 ) ) -RRB- cord-016652-x8t3lf1x 179 8 . . . cord-016652-x8t3lf1x 180 1 The the DT cord-016652-x8t3lf1x 180 2 hepatitis hepatitis NN cord-016652-x8t3lf1x 180 3 delta delta NNP cord-016652-x8t3lf1x 180 4 virus virus NN cord-016652-x8t3lf1x 180 5 genome genome NN cord-016652-x8t3lf1x 180 6 also also RB cord-016652-x8t3lf1x 180 7 has have VBZ cord-016652-x8t3lf1x 180 8 differential differential JJ cord-016652-x8t3lf1x 180 9 synthesis synthesis NN cord-016652-x8t3lf1x 180 10 in in IN cord-016652-x8t3lf1x 180 11 the the DT cord-016652-x8t3lf1x 180 12 nucleus nucleus NN cord-016652-x8t3lf1x 180 13 with with IN cord-016652-x8t3lf1x 180 14 RNA RNA NNP cord-016652-x8t3lf1x 180 15 being be VBG cord-016652-x8t3lf1x 180 16 transcribed transcribe VBN cord-016652-x8t3lf1x 180 17 in in IN cord-016652-x8t3lf1x 180 18 the the DT cord-016652-x8t3lf1x 180 19 nucleolus nucleolus NN cord-016652-x8t3lf1x 181 1 ( ( -LRB- cord-016652-x8t3lf1x 181 2 Huang Huang NNP cord-016652-x8t3lf1x 181 3 et et NNP cord-016652-x8t3lf1x 181 4 al al NNP cord-016652-x8t3lf1x 181 5 . . NNP cord-016652-x8t3lf1x 181 6 2001 2001 CD cord-016652-x8t3lf1x 181 7 ) ) -RRB- cord-016652-x8t3lf1x 182 1 ; ; : cord-016652-x8t3lf1x 182 2 this this DT cord-016652-x8t3lf1x 182 3 is be VBZ cord-016652-x8t3lf1x 182 4 similar similar JJ cord-016652-x8t3lf1x 182 5 to to IN cord-016652-x8t3lf1x 182 6 the the DT cord-016652-x8t3lf1x 182 7 potato potato NN cord-016652-x8t3lf1x 182 8 spindle spindle NN cord-016652-x8t3lf1x 182 9 tuber tuber NN cord-016652-x8t3lf1x 182 10 viroid viroid NN cord-016652-x8t3lf1x 182 11 where where WRB cord-016652-x8t3lf1x 182 12 RNAs rna NNS cord-016652-x8t3lf1x 182 13 of of IN cord-016652-x8t3lf1x 182 14 opposite opposite JJ cord-016652-x8t3lf1x 182 15 polarity polarity NN cord-016652-x8t3lf1x 182 16 are be VBP cord-016652-x8t3lf1x 182 17 sequestered sequester VBN cord-016652-x8t3lf1x 182 18 in in IN cord-016652-x8t3lf1x 182 19 different different JJ cord-016652-x8t3lf1x 182 20 nuclear nuclear JJ cord-016652-x8t3lf1x 182 21 compartments compartment NNS cord-016652-x8t3lf1x 182 22 , , , cord-016652-x8t3lf1x 182 23 with with IN cord-016652-x8t3lf1x 182 24 the the DT cord-016652-x8t3lf1x 182 25 positive positive JJ cord-016652-x8t3lf1x 182 26 - - HYPH cord-016652-x8t3lf1x 182 27 sense sense NN cord-016652-x8t3lf1x 182 28 RNA RNA NNP cord-016652-x8t3lf1x 182 29 being be VBG cord-016652-x8t3lf1x 182 30 transported transport VBN cord-016652-x8t3lf1x 182 31 to to IN cord-016652-x8t3lf1x 182 32 the the DT cord-016652-x8t3lf1x 182 33 nucleolus nucleolus NN cord-016652-x8t3lf1x 182 34 . . . cord-016652-x8t3lf1x 183 1 Again again RB cord-016652-x8t3lf1x 183 2 localisation localisation NN cord-016652-x8t3lf1x 183 3 to to IN cord-016652-x8t3lf1x 183 4 different different JJ cord-016652-x8t3lf1x 183 5 sub sub JJ cord-016652-x8t3lf1x 183 6 - - JJ cord-016652-x8t3lf1x 183 7 nuclear nuclear JJ cord-016652-x8t3lf1x 183 8 strcutures strcuture NNS cord-016652-x8t3lf1x 183 9 may may MD cord-016652-x8t3lf1x 183 10 have have VB cord-016652-x8t3lf1x 183 11 different different JJ cord-016652-x8t3lf1x 183 12 roles role NNS cord-016652-x8t3lf1x 183 13 in in IN cord-016652-x8t3lf1x 183 14 the the DT cord-016652-x8t3lf1x 183 15 virus virus NN cord-016652-x8t3lf1x 183 16 life life NN cord-016652-x8t3lf1x 183 17 cycle cycle NN cord-016652-x8t3lf1x 183 18 ( ( -LRB- cord-016652-x8t3lf1x 183 19 Li Li NNP cord-016652-x8t3lf1x 183 20 et et NNP cord-016652-x8t3lf1x 183 21 al al NNP cord-016652-x8t3lf1x 183 22 . . . cord-016652-x8t3lf1x 183 23 2006 2006 CD cord-016652-x8t3lf1x 183 24 ) ) -RRB- cord-016652-x8t3lf1x 183 25 . . . cord-016652-x8t3lf1x 184 1 An an DT cord-016652-x8t3lf1x 184 2 intriguing intriguing JJ cord-016652-x8t3lf1x 184 3 recent recent JJ cord-016652-x8t3lf1x 184 4 discovery discovery NN cord-016652-x8t3lf1x 184 5 has have VBZ cord-016652-x8t3lf1x 184 6 been be VBN cord-016652-x8t3lf1x 184 7 made make VBN cord-016652-x8t3lf1x 184 8 showing show VBG cord-016652-x8t3lf1x 184 9 that that IN cord-016652-x8t3lf1x 184 10 adenoassociated adenoassociate VBN cord-016652-x8t3lf1x 184 11 virus virus NN cord-016652-x8t3lf1x 184 12 ( ( -LRB- cord-016652-x8t3lf1x 184 13 AAV AAV NNP cord-016652-x8t3lf1x 184 14 ) ) -RRB- cord-016652-x8t3lf1x 184 15 encodes encode VBZ cord-016652-x8t3lf1x 184 16 an an DT cord-016652-x8t3lf1x 184 17 additional additional JJ cord-016652-x8t3lf1x 184 18 protein protein NN cord-016652-x8t3lf1x 184 19 called call VBN cord-016652-x8t3lf1x 184 20 assembly assembly NN cord-016652-x8t3lf1x 184 21 - - HYPH cord-016652-x8t3lf1x 184 22 activating activate VBG cord-016652-x8t3lf1x 184 23 protein protein NN cord-016652-x8t3lf1x 184 24 ( ( -LRB- cord-016652-x8t3lf1x 184 25 AAP AAP NNP cord-016652-x8t3lf1x 184 26 ) ) -RRB- cord-016652-x8t3lf1x 184 27 that that IN cord-016652-x8t3lf1x 184 28 localises localise VBZ cord-016652-x8t3lf1x 184 29 to to IN cord-016652-x8t3lf1x 184 30 the the DT cord-016652-x8t3lf1x 184 31 nucleolus nucleolus NN cord-016652-x8t3lf1x 184 32 and and CC cord-016652-x8t3lf1x 184 33 promotes promote VBZ cord-016652-x8t3lf1x 184 34 assembly assembly NN cord-016652-x8t3lf1x 184 35 of of IN cord-016652-x8t3lf1x 184 36 the the DT cord-016652-x8t3lf1x 184 37 viral viral JJ cord-016652-x8t3lf1x 184 38 capsid capsid NN cord-016652-x8t3lf1x 184 39 ( ( -LRB- cord-016652-x8t3lf1x 184 40 Sonntag Sonntag NNP cord-016652-x8t3lf1x 184 41 et et NNP cord-016652-x8t3lf1x 184 42 al al NNP cord-016652-x8t3lf1x 184 43 . . NNP cord-016652-x8t3lf1x 184 44 2010 2010 CD cord-016652-x8t3lf1x 184 45 ) ) -RRB- cord-016652-x8t3lf1x 184 46 . . . cord-016652-x8t3lf1x 185 1 As as IN cord-016652-x8t3lf1x 185 2 a a DT cord-016652-x8t3lf1x 185 3 result result NN cord-016652-x8t3lf1x 185 4 of of IN cord-016652-x8t3lf1x 185 5 their -PRON- PRP$ cord-016652-x8t3lf1x 185 6 limited limited JJ cord-016652-x8t3lf1x 185 7 genomes genome NNS cord-016652-x8t3lf1x 185 8 and and CC cord-016652-x8t3lf1x 185 9 coding code VBG cord-016652-x8t3lf1x 185 10 capacities capacity NNS cord-016652-x8t3lf1x 185 11 , , , cord-016652-x8t3lf1x 185 12 recruitment recruitment NN cord-016652-x8t3lf1x 185 13 of of IN cord-016652-x8t3lf1x 185 14 cellular cellular JJ cord-016652-x8t3lf1x 185 15 proteins protein NNS cord-016652-x8t3lf1x 185 16 with with IN cord-016652-x8t3lf1x 185 17 defined define VBN cord-016652-x8t3lf1x 185 18 functions function NNS cord-016652-x8t3lf1x 185 19 in in IN cord-016652-x8t3lf1x 185 20 RNA RNA NNP cord-016652-x8t3lf1x 185 21 metabolism metabolism NN cord-016652-x8t3lf1x 185 22 would would MD cord-016652-x8t3lf1x 185 23 be be VB cord-016652-x8t3lf1x 185 24 a a DT cord-016652-x8t3lf1x 185 25 logical logical JJ cord-016652-x8t3lf1x 185 26 step step NN cord-016652-x8t3lf1x 185 27 to to TO cord-016652-x8t3lf1x 185 28 facilitate facilitate VB cord-016652-x8t3lf1x 185 29 RNA RNA NNP cord-016652-x8t3lf1x 185 30 virus virus NN cord-016652-x8t3lf1x 185 31 infection infection NN cord-016652-x8t3lf1x 185 32 . . . cord-016652-x8t3lf1x 186 1 As as IN cord-016652-x8t3lf1x 186 2 nucleolar nucleolar JJ cord-016652-x8t3lf1x 186 3 proteins protein NNS cord-016652-x8t3lf1x 186 4 have have VBP cord-016652-x8t3lf1x 186 5 many many JJ cord-016652-x8t3lf1x 186 6 crucial crucial JJ cord-016652-x8t3lf1x 186 7 functions function NNS cord-016652-x8t3lf1x 186 8 in in IN cord-016652-x8t3lf1x 186 9 cellular cellular JJ cord-016652-x8t3lf1x 186 10 RNA RNA NNP cord-016652-x8t3lf1x 186 11 biosynthesis biosynthesis NN cord-016652-x8t3lf1x 186 12 , , , cord-016652-x8t3lf1x 186 13 processing processing NN cord-016652-x8t3lf1x 186 14 and and CC cord-016652-x8t3lf1x 186 15 translation translation NN cord-016652-x8t3lf1x 186 16 , , , cord-016652-x8t3lf1x 186 17 it -PRON- PRP cord-016652-x8t3lf1x 186 18 comes come VBZ cord-016652-x8t3lf1x 186 19 as as IN cord-016652-x8t3lf1x 186 20 no no DT cord-016652-x8t3lf1x 186 21 surprise surprise NN cord-016652-x8t3lf1x 186 22 that that IN cord-016652-x8t3lf1x 186 23 nucleolar nucleolar JJ cord-016652-x8t3lf1x 186 24 proteins protein NNS cord-016652-x8t3lf1x 186 25 are be VBP cord-016652-x8t3lf1x 186 26 incorporated incorporate VBN cord-016652-x8t3lf1x 186 27 into into IN cord-016652-x8t3lf1x 186 28 the the DT cord-016652-x8t3lf1x 186 29 replication replication NN cord-016652-x8t3lf1x 186 30 and/or and/or CC cord-016652-x8t3lf1x 186 31 translation translation NN cord-016652-x8t3lf1x 186 32 complexes complex NNS cord-016652-x8t3lf1x 186 33 formed form VBN cord-016652-x8t3lf1x 186 34 by by IN cord-016652-x8t3lf1x 186 35 RNA RNA NNP cord-016652-x8t3lf1x 186 36 viruses virus NNS cord-016652-x8t3lf1x 186 37 . . . cord-016652-x8t3lf1x 187 1 Given give VBN cord-016652-x8t3lf1x 187 2 that that IN cord-016652-x8t3lf1x 187 3 some some DT cord-016652-x8t3lf1x 187 4 nucleolar nucleolar JJ cord-016652-x8t3lf1x 187 5 proteins protein NNS cord-016652-x8t3lf1x 187 6 have have VBP cord-016652-x8t3lf1x 187 7 many many JJ cord-016652-x8t3lf1x 187 8 different different JJ cord-016652-x8t3lf1x 187 9 functions function NNS cord-016652-x8t3lf1x 187 10 , , , cord-016652-x8t3lf1x 187 11 the the DT cord-016652-x8t3lf1x 187 12 same same JJ cord-016652-x8t3lf1x 187 13 nucleolar nucleolar JJ cord-016652-x8t3lf1x 187 14 protein protein NN cord-016652-x8t3lf1x 187 15 might may MD cord-016652-x8t3lf1x 187 16 be be VB cord-016652-x8t3lf1x 187 17 used use VBN cord-016652-x8t3lf1x 187 18 by by IN cord-016652-x8t3lf1x 187 19 a a DT cord-016652-x8t3lf1x 187 20 virus virus NN cord-016652-x8t3lf1x 187 21 for for IN cord-016652-x8t3lf1x 187 22 different different JJ cord-016652-x8t3lf1x 187 23 aspects aspect NNS cord-016652-x8t3lf1x 187 24 of of IN cord-016652-x8t3lf1x 187 25 the the DT cord-016652-x8t3lf1x 187 26 replication replication NN cord-016652-x8t3lf1x 187 27 pathway pathway NN cord-016652-x8t3lf1x 187 28 . . . cord-016652-x8t3lf1x 188 1 Studies study NNS cord-016652-x8t3lf1x 188 2 suggest suggest VBP cord-016652-x8t3lf1x 188 3 that that IN cord-016652-x8t3lf1x 188 4 the the DT cord-016652-x8t3lf1x 188 5 human human JJ cord-016652-x8t3lf1x 188 6 rhinovirus rhinovirus NN cord-016652-x8t3lf1x 188 7 3 3 CD cord-016652-x8t3lf1x 188 8 C c NN cord-016652-x8t3lf1x 188 9 protease protease NN cord-016652-x8t3lf1x 188 10 ( ( -LRB- cord-016652-x8t3lf1x 188 11 3Cpro 3Cpro NNP cord-016652-x8t3lf1x 188 12 ) ) -RRB- cord-016652-x8t3lf1x 188 13 pre pre NNS cord-016652-x8t3lf1x 188 14 - - NNS cord-016652-x8t3lf1x 188 15 cursors cursor NNS cord-016652-x8t3lf1x 188 16 , , , cord-016652-x8t3lf1x 188 17 3CD 3CD NNP cord-016652-x8t3lf1x 188 18 ' ' '' cord-016652-x8t3lf1x 188 19 and/or and/or CC cord-016652-x8t3lf1x 188 20 3CD 3CD NNP cord-016652-x8t3lf1x 188 21 , , , cord-016652-x8t3lf1x 188 22 localise localise VB cord-016652-x8t3lf1x 188 23 in in IN cord-016652-x8t3lf1x 188 24 the the DT cord-016652-x8t3lf1x 188 25 nucleoli nucleoli NNP cord-016652-x8t3lf1x 188 26 of of IN cord-016652-x8t3lf1x 188 27 infected infected JJ cord-016652-x8t3lf1x 188 28 cells cell NNS cord-016652-x8t3lf1x 188 29 early early RB cord-016652-x8t3lf1x 188 30 in in IN cord-016652-x8t3lf1x 188 31 infection infection NN cord-016652-x8t3lf1x 188 32 and and CC cord-016652-x8t3lf1x 188 33 inhibit inhibit VB cord-016652-x8t3lf1x 188 34 cellular cellular JJ cord-016652-x8t3lf1x 188 35 RNA RNA NNP cord-016652-x8t3lf1x 188 36 transcription transcription NN cord-016652-x8t3lf1x 188 37 via via IN cord-016652-x8t3lf1x 188 38 proteolytic proteolytic JJ cord-016652-x8t3lf1x 188 39 mechanisms mechanism NNS cord-016652-x8t3lf1x 188 40 ( ( -LRB- cord-016652-x8t3lf1x 188 41 Amineva Amineva NNP cord-016652-x8t3lf1x 188 42 et et NNP cord-016652-x8t3lf1x 188 43 al al NNP cord-016652-x8t3lf1x 188 44 . . . cord-016652-x8t3lf1x 188 45 2004 2004 CD cord-016652-x8t3lf1x 188 46 ) ) -RRB- cord-016652-x8t3lf1x 188 47 . . . cord-016652-x8t3lf1x 189 1 This this DT cord-016652-x8t3lf1x 189 2 general general JJ cord-016652-x8t3lf1x 189 3 property property NN cord-016652-x8t3lf1x 189 4 is be VBZ cord-016652-x8t3lf1x 189 5 not not RB cord-016652-x8t3lf1x 189 6 restricted restrict VBN cord-016652-x8t3lf1x 189 7 to to IN cord-016652-x8t3lf1x 189 8 human human JJ cord-016652-x8t3lf1x 189 9 rhinovirus rhinovirus NN cord-016652-x8t3lf1x 189 10 and and CC cord-016652-x8t3lf1x 189 11 in in IN cord-016652-x8t3lf1x 189 12 terms term NNS cord-016652-x8t3lf1x 189 13 of of IN cord-016652-x8t3lf1x 189 14 the the DT cord-016652-x8t3lf1x 189 15 inhibition inhibition NN cord-016652-x8t3lf1x 189 16 of of IN cord-016652-x8t3lf1x 189 17 cellular cellular JJ cord-016652-x8t3lf1x 189 18 translation translation NN cord-016652-x8t3lf1x 189 19 has have VBZ cord-016652-x8t3lf1x 189 20 also also RB cord-016652-x8t3lf1x 189 21 been be VBN cord-016652-x8t3lf1x 189 22 described describe VBN cord-016652-x8t3lf1x 189 23 for for IN cord-016652-x8t3lf1x 189 24 encephalomyocarditis encephalomyocarditis NNP cord-016652-x8t3lf1x 189 25 virus virus NN cord-016652-x8t3lf1x 189 26 ( ( -LRB- cord-016652-x8t3lf1x 189 27 Aminev Aminev NNP cord-016652-x8t3lf1x 189 28 et et FW cord-016652-x8t3lf1x 189 29 al al NNP cord-016652-x8t3lf1x 189 30 . . . cord-016652-x8t3lf1x 190 1 2003a 2003a CD cord-016652-x8t3lf1x 190 2 , , , cord-016652-x8t3lf1x 190 3 b b LS cord-016652-x8t3lf1x 190 4 ) ) -RRB- cord-016652-x8t3lf1x 190 5 , , , cord-016652-x8t3lf1x 190 6 again again RB cord-016652-x8t3lf1x 190 7 suggesting suggest VBG cord-016652-x8t3lf1x 190 8 roles role NNS cord-016652-x8t3lf1x 190 9 in in IN cord-016652-x8t3lf1x 190 10 translational translational JJ cord-016652-x8t3lf1x 190 11 regulation regulation NN cord-016652-x8t3lf1x 190 12 . . . cord-016652-x8t3lf1x 191 1 Given give VBN cord-016652-x8t3lf1x 191 2 the the DT cord-016652-x8t3lf1x 191 3 many many JJ cord-016652-x8t3lf1x 191 4 roles role NNS cord-016652-x8t3lf1x 191 5 of of IN cord-016652-x8t3lf1x 191 6 the the DT cord-016652-x8t3lf1x 191 7 nucleolus nucleolus NN cord-016652-x8t3lf1x 191 8 in in IN cord-016652-x8t3lf1x 191 9 the the DT cord-016652-x8t3lf1x 191 10 life life NN cord-016652-x8t3lf1x 191 11 cycle cycle NN cord-016652-x8t3lf1x 191 12 of of IN cord-016652-x8t3lf1x 191 13 the the DT cord-016652-x8t3lf1x 191 14 cell cell NN cord-016652-x8t3lf1x 191 15 , , , cord-016652-x8t3lf1x 191 16 including include VBG cord-016652-x8t3lf1x 191 17 as as IN cord-016652-x8t3lf1x 191 18 stress stress NN cord-016652-x8t3lf1x 191 19 sensor sensor NN cord-016652-x8t3lf1x 191 20 ( ( -LRB- cord-016652-x8t3lf1x 191 21 Boulon Boulon NNP cord-016652-x8t3lf1x 191 22 et et NNP cord-016652-x8t3lf1x 191 23 al al NNP cord-016652-x8t3lf1x 191 24 . . NNP cord-016652-x8t3lf1x 191 25 2010 2010 CD cord-016652-x8t3lf1x 191 26 ; ; : cord-016652-x8t3lf1x 191 27 Mayer Mayer NNP cord-016652-x8t3lf1x 191 28 and and CC cord-016652-x8t3lf1x 191 29 Grummt Grummt NNP cord-016652-x8t3lf1x 191 30 2005 2005 CD cord-016652-x8t3lf1x 191 31 ) ) -RRB- cord-016652-x8t3lf1x 191 32 , , , cord-016652-x8t3lf1x 191 33 it -PRON- PRP cord-016652-x8t3lf1x 191 34 would would MD cord-016652-x8t3lf1x 191 35 seem seem VB cord-016652-x8t3lf1x 191 36 reasonable reasonable JJ cord-016652-x8t3lf1x 191 37 that that IN cord-016652-x8t3lf1x 191 38 comprehensive comprehensive JJ cord-016652-x8t3lf1x 191 39 unbiased unbiased JJ cord-016652-x8t3lf1x 191 40 analysis analysis NN cord-016652-x8t3lf1x 191 41 of of IN cord-016652-x8t3lf1x 191 42 the the DT cord-016652-x8t3lf1x 191 43 nucleolar nucleolar NNP cord-016652-x8t3lf1x 191 44 proteome proteome NN cord-016652-x8t3lf1x 191 45 would would MD cord-016652-x8t3lf1x 191 46 yield yield VB cord-016652-x8t3lf1x 191 47 interesting interesting JJ cord-016652-x8t3lf1x 191 48 data datum NNS cord-016652-x8t3lf1x 191 49 , , , cord-016652-x8t3lf1x 191 50 particularly particularly RB cord-016652-x8t3lf1x 191 51 , , , cord-016652-x8t3lf1x 191 52 with with IN cord-016652-x8t3lf1x 191 53 providing provide VBG cord-016652-x8t3lf1x 191 54 clues clue NNS cord-016652-x8t3lf1x 191 55 as as IN cord-016652-x8t3lf1x 191 56 to to IN cord-016652-x8t3lf1x 191 57 what what WP cord-016652-x8t3lf1x 191 58 cellular cellular JJ cord-016652-x8t3lf1x 191 59 nucleolar nucleolar JJ cord-016652-x8t3lf1x 191 60 functions function NNS cord-016652-x8t3lf1x 191 61 may may MD cord-016652-x8t3lf1x 191 62 be be VB cord-016652-x8t3lf1x 191 63 altered alter VBN cord-016652-x8t3lf1x 191 64 by by IN cord-016652-x8t3lf1x 191 65 virus virus NN cord-016652-x8t3lf1x 191 66 infection infection NN cord-016652-x8t3lf1x 191 67 and and CC cord-016652-x8t3lf1x 191 68 what what WP cord-016652-x8t3lf1x 191 69 mechanisms mechanism VBZ cord-016652-x8t3lf1x 191 70 the the DT cord-016652-x8t3lf1x 191 71 nucleolus nucleolus NN cord-016652-x8t3lf1x 191 72 may may MD cord-016652-x8t3lf1x 191 73 use use VB cord-016652-x8t3lf1x 191 74 to to TO cord-016652-x8t3lf1x 191 75 respond respond VB cord-016652-x8t3lf1x 191 76 to to IN cord-016652-x8t3lf1x 191 77 this this DT cord-016652-x8t3lf1x 191 78 . . . cord-016652-x8t3lf1x 192 1 How how WRB cord-016652-x8t3lf1x 192 2 the the DT cord-016652-x8t3lf1x 192 3 nucleolar nucleolar JJ cord-016652-x8t3lf1x 192 4 proteome proteome NN cord-016652-x8t3lf1x 192 5 changes change NNS cord-016652-x8t3lf1x 192 6 in in IN cord-016652-x8t3lf1x 192 7 response response NN cord-016652-x8t3lf1x 192 8 to to IN cord-016652-x8t3lf1x 192 9 virus virus NN cord-016652-x8t3lf1x 192 10 - - HYPH cord-016652-x8t3lf1x 192 11 infection infection NN cord-016652-x8t3lf1x 192 12 has have VBZ cord-016652-x8t3lf1x 192 13 been be VBN cord-016652-x8t3lf1x 192 14 investigated investigate VBN cord-016652-x8t3lf1x 192 15 using use VBG cord-016652-x8t3lf1x 192 16 stable stable JJ cord-016652-x8t3lf1x 192 17 isotope isotope NN cord-016652-x8t3lf1x 192 18 labelling labelling NN cord-016652-x8t3lf1x 192 19 with with IN cord-016652-x8t3lf1x 192 20 amino amino JJ cord-016652-x8t3lf1x 192 21 acids acid NNS cord-016652-x8t3lf1x 192 22 in in IN cord-016652-x8t3lf1x 192 23 cell cell NN cord-016652-x8t3lf1x 192 24 culture culture NN cord-016652-x8t3lf1x 192 25 ( ( -LRB- cord-016652-x8t3lf1x 192 26 SILAC SILAC NNP cord-016652-x8t3lf1x 192 27 ) ) -RRB- cord-016652-x8t3lf1x 192 28 coupled couple VBN cord-016652-x8t3lf1x 192 29 to to IN cord-016652-x8t3lf1x 192 30 LC LC NNP cord-016652-x8t3lf1x 192 31 - - HYPH cord-016652-x8t3lf1x 192 32 MS MS NNP cord-016652-x8t3lf1x 192 33 / / SYM cord-016652-x8t3lf1x 192 34 MS MS NNP cord-016652-x8t3lf1x 192 35 and and CC cord-016652-x8t3lf1x 192 36 bioinformatics bioinformatics NNP cord-016652-x8t3lf1x 192 37 ( ( -LRB- cord-016652-x8t3lf1x 192 38 Fig Fig NNP cord-016652-x8t3lf1x 192 39 . . NNP cord-016652-x8t3lf1x 192 40 14.1 14.1 CD cord-016652-x8t3lf1x 192 41 ) ) -RRB- cord-016652-x8t3lf1x 192 42 . . . cord-016652-x8t3lf1x 193 1 These these DT cord-016652-x8t3lf1x 193 2 studies study NNS cord-016652-x8t3lf1x 193 3 , , , cord-016652-x8t3lf1x 193 4 led lead VBN cord-016652-x8t3lf1x 193 5 by by IN cord-016652-x8t3lf1x 193 6 our -PRON- PRP$ cord-016652-x8t3lf1x 193 7 laboratories laboratory NNS cord-016652-x8t3lf1x 193 8 , , , cord-016652-x8t3lf1x 193 9 have have VBP cord-016652-x8t3lf1x 193 10 analysed analyse VBN cord-016652-x8t3lf1x 193 11 purified purify VBN cord-016652-x8t3lf1x 193 12 nucleoli nucleoli NNP cord-016652-x8t3lf1x 193 13 and and CC cord-016652-x8t3lf1x 193 14 the the DT cord-016652-x8t3lf1x 193 15 nucleus nucleus NN cord-016652-x8t3lf1x 193 16 , , , cord-016652-x8t3lf1x 193 17 and and CC cord-016652-x8t3lf1x 193 18 have have VBP cord-016652-x8t3lf1x 193 19 directly directly RB cord-016652-x8t3lf1x 193 20 stemmed stem VBN cord-016652-x8t3lf1x 193 21 from from IN cord-016652-x8t3lf1x 193 22 the the DT cord-016652-x8t3lf1x 193 23 pioneering pioneering JJ cord-016652-x8t3lf1x 193 24 work work NN cord-016652-x8t3lf1x 193 25 of of IN cord-016652-x8t3lf1x 193 26 the the DT cord-016652-x8t3lf1x 193 27 Lamond Lamond NNP cord-016652-x8t3lf1x 193 28 laboratory laboratory NN cord-016652-x8t3lf1x 193 29 in in IN cord-016652-x8t3lf1x 193 30 analysing analyse VBG cord-016652-x8t3lf1x 193 31 purified purify VBN cord-016652-x8t3lf1x 193 32 nucleoli nucleolus NNS cord-016652-x8t3lf1x 193 33 using use VBG cord-016652-x8t3lf1x 193 34 quantitative quantitative JJ cord-016652-x8t3lf1x 193 35 proteomics proteomic NNS cord-016652-x8t3lf1x 193 36 ( ( -LRB- cord-016652-x8t3lf1x 193 37 Andersen Andersen NNP cord-016652-x8t3lf1x 193 38 et et NNP cord-016652-x8t3lf1x 193 39 al al NNP cord-016652-x8t3lf1x 193 40 . . . cord-016652-x8t3lf1x 194 1 2005 2005 CD cord-016652-x8t3lf1x 195 1 ( ( -LRB- cord-016652-x8t3lf1x 195 2 Munday Munday NNP cord-016652-x8t3lf1x 195 3 et et NNP cord-016652-x8t3lf1x 195 4 al al NNP cord-016652-x8t3lf1x 195 5 . . NNP cord-016652-x8t3lf1x 195 6 2010 2010 CD cord-016652-x8t3lf1x 195 7 ) ) -RRB- cord-016652-x8t3lf1x 195 8 . . . cord-016652-x8t3lf1x 196 1 Overall overall RB cord-016652-x8t3lf1x 196 2 , , , cord-016652-x8t3lf1x 196 3 our -PRON- PRP$ cord-016652-x8t3lf1x 196 4 data data NN cord-016652-x8t3lf1x 196 5 indicates indicate VBZ cord-016652-x8t3lf1x 196 6 that that IN cord-016652-x8t3lf1x 196 7 only only RB cord-016652-x8t3lf1x 196 8 a a DT cord-016652-x8t3lf1x 196 9 small small JJ cord-016652-x8t3lf1x 196 10 proportion proportion NN cord-016652-x8t3lf1x 196 11 of of IN cord-016652-x8t3lf1x 196 12 nucleolar nucleolar JJ cord-016652-x8t3lf1x 196 13 proteins protein NNS cord-016652-x8t3lf1x 196 14 change change VBP cord-016652-x8t3lf1x 196 15 in in IN cord-016652-x8t3lf1x 196 16 abundance abundance NN cord-016652-x8t3lf1x 196 17 in in IN cord-016652-x8t3lf1x 196 18 virus virus NN cord-016652-x8t3lf1x 196 19 - - HYPH cord-016652-x8t3lf1x 196 20 infected infect VBN cord-016652-x8t3lf1x 196 21 cells cell NNS cord-016652-x8t3lf1x 196 22 , , , cord-016652-x8t3lf1x 196 23 Fig Fig NNP cord-016652-x8t3lf1x 196 24 . . NNP cord-016652-x8t3lf1x 196 25 14 14 CD cord-016652-x8t3lf1x 196 26 . . . cord-016652-x8t3lf1x 197 1 1 1 CD cord-016652-x8t3lf1x 197 2 Diagram Diagram NNP cord-016652-x8t3lf1x 197 3 of of IN cord-016652-x8t3lf1x 197 4 a a DT cord-016652-x8t3lf1x 197 5 " " `` cord-016652-x8t3lf1x 197 6 classic classic JJ cord-016652-x8t3lf1x 197 7 " " '' cord-016652-x8t3lf1x 197 8 SILAC silac NN cord-016652-x8t3lf1x 197 9 experiment experiment NN cord-016652-x8t3lf1x 197 10 . . . cord-016652-x8t3lf1x 198 1 This this DT cord-016652-x8t3lf1x 198 2 technology technology NN cord-016652-x8t3lf1x 198 3 allows allow VBZ cord-016652-x8t3lf1x 198 4 high high JJ cord-016652-x8t3lf1x 198 5 - - HYPH cord-016652-x8t3lf1x 198 6 throughput throughput NN cord-016652-x8t3lf1x 198 7 quantitative quantitative JJ cord-016652-x8t3lf1x 198 8 proteomics proteomic NNS cord-016652-x8t3lf1x 198 9 and and CC cord-016652-x8t3lf1x 198 10 has have VBZ cord-016652-x8t3lf1x 198 11 been be VBN cord-016652-x8t3lf1x 198 12 readily readily RB cord-016652-x8t3lf1x 198 13 applied apply VBN cord-016652-x8t3lf1x 198 14 to to IN cord-016652-x8t3lf1x 198 15 the the DT cord-016652-x8t3lf1x 198 16 nucleolus nucleolus NN cord-016652-x8t3lf1x 198 17 , , , cord-016652-x8t3lf1x 198 18 especially especially RB cord-016652-x8t3lf1x 198 19 when when WRB cord-016652-x8t3lf1x 198 20 coupled couple VBN cord-016652-x8t3lf1x 198 21 with with IN cord-016652-x8t3lf1x 198 22 dynamic dynamic JJ cord-016652-x8t3lf1x 198 23 live live JJ cord-016652-x8t3lf1x 198 24 - - HYPH cord-016652-x8t3lf1x 198 25 cell cell NN cord-016652-x8t3lf1x 198 26 imaging imaging NN cord-016652-x8t3lf1x 198 27 ( ( -LRB- cord-016652-x8t3lf1x 198 28 Andersen Andersen NNP cord-016652-x8t3lf1x 198 29 et et NNP cord-016652-x8t3lf1x 198 30 al al NNP cord-016652-x8t3lf1x 198 31 . . NNP cord-016652-x8t3lf1x 198 32 2005 2005 CD cord-016652-x8t3lf1x 198 33 ) ) -RRB- cord-016652-x8t3lf1x 198 34 . . . cord-016652-x8t3lf1x 199 1 The the DT cord-016652-x8t3lf1x 199 2 ability ability NN cord-016652-x8t3lf1x 199 3 to to TO cord-016652-x8t3lf1x 199 4 simultaneously simultaneously RB cord-016652-x8t3lf1x 199 5 compare compare VB cord-016652-x8t3lf1x 199 6 up up IN cord-016652-x8t3lf1x 199 7 to to TO cord-016652-x8t3lf1x 199 8 three three CD cord-016652-x8t3lf1x 199 9 different different JJ cord-016652-x8t3lf1x 199 10 conditions condition NNS cord-016652-x8t3lf1x 199 11 through through IN cord-016652-x8t3lf1x 199 12 selection selection NN cord-016652-x8t3lf1x 199 13 of of IN cord-016652-x8t3lf1x 199 14 the the DT cord-016652-x8t3lf1x 199 15 appropriate appropriate JJ cord-016652-x8t3lf1x 199 16 isotope isotope NN cord-016652-x8t3lf1x 199 17 label label NN cord-016652-x8t3lf1x 199 18 has have VBZ cord-016652-x8t3lf1x 199 19 enabled enable VBN cord-016652-x8t3lf1x 199 20 the the DT cord-016652-x8t3lf1x 199 21 recent recent JJ cord-016652-x8t3lf1x 199 22 studies study NNS cord-016652-x8t3lf1x 199 23 of of IN cord-016652-x8t3lf1x 199 24 how how WRB cord-016652-x8t3lf1x 199 25 the the DT cord-016652-x8t3lf1x 199 26 nucleolar nucleolar JJ cord-016652-x8t3lf1x 199 27 proteome proteome NN cord-016652-x8t3lf1x 199 28 changes change NNS cord-016652-x8t3lf1x 199 29 in in IN cord-016652-x8t3lf1x 199 30 virus virus NN cord-016652-x8t3lf1x 199 31 - - HYPH cord-016652-x8t3lf1x 199 32 infected infect VBN cord-016652-x8t3lf1x 199 33 cells cell NNS cord-016652-x8t3lf1x 200 1 ( ( -LRB- cord-016652-x8t3lf1x 200 2 Emmott Emmott NNP cord-016652-x8t3lf1x 200 3 et et NNP cord-016652-x8t3lf1x 200 4 al al NNP cord-016652-x8t3lf1x 200 5 . . . cord-016652-x8t3lf1x 201 1 2010a 2010a NNS cord-016652-x8t3lf1x 201 2 ; ; : cord-016652-x8t3lf1x 202 1 Emmott Emmott NNP cord-016652-x8t3lf1x 202 2 et et NNP cord-016652-x8t3lf1x 202 3 al al NNP cord-016652-x8t3lf1x 202 4 . . . cord-016652-x8t3lf1x 203 1 2010b 2010b CD cord-016652-x8t3lf1x 203 2 ; ; : cord-016652-x8t3lf1x 204 1 Emmott Emmott NNP cord-016652-x8t3lf1x 204 2 et et NNP cord-016652-x8t3lf1x 204 3 al al NNP cord-016652-x8t3lf1x 204 4 . . . cord-016652-x8t3lf1x 205 1 2010c 2010c CD cord-016652-x8t3lf1x 206 1 ; ; : cord-016652-x8t3lf1x 206 2 Hiscox Hiscox NNP cord-016652-x8t3lf1x 206 3 et et NNP cord-016652-x8t3lf1x 206 4 al al NNP cord-016652-x8t3lf1x 206 5 . . . cord-016652-x8t3lf1x 207 1 2010 2010 CD cord-016652-x8t3lf1x 207 2 ; ; : cord-016652-x8t3lf1x 207 3 Lam Lam NNP cord-016652-x8t3lf1x 207 4 et et NNP cord-016652-x8t3lf1x 207 5 al al NNP cord-016652-x8t3lf1x 207 6 . . NNP cord-016652-x8t3lf1x 207 7 2010 2010 CD cord-016652-x8t3lf1x 207 8 ) ) -RRB- cord-016652-x8t3lf1x 207 9 and and CC cord-016652-x8t3lf1x 207 10 these these DT cord-016652-x8t3lf1x 207 11 tend tend VBP cord-016652-x8t3lf1x 207 12 to to TO cord-016652-x8t3lf1x 207 13 be be VB cord-016652-x8t3lf1x 207 14 virus virus NN cord-016652-x8t3lf1x 207 15 - - HYPH cord-016652-x8t3lf1x 207 16 specific specific JJ cord-016652-x8t3lf1x 207 17 . . . cord-016652-x8t3lf1x 208 1 For for IN cord-016652-x8t3lf1x 208 2 example example NN cord-016652-x8t3lf1x 208 3 , , , cord-016652-x8t3lf1x 208 4 in in IN cord-016652-x8t3lf1x 208 5 adenovirus adenovirus NN cord-016652-x8t3lf1x 208 6 infected infect VBN cord-016652-x8t3lf1x 208 7 cells cell NNS cord-016652-x8t3lf1x 208 8 just just RB cord-016652-x8t3lf1x 208 9 7 7 CD cord-016652-x8t3lf1x 208 10 % % NN cord-016652-x8t3lf1x 208 11 of of IN cord-016652-x8t3lf1x 208 12 proteins protein NNS cord-016652-x8t3lf1x 208 13 identified identify VBN cord-016652-x8t3lf1x 208 14 show show VBP cord-016652-x8t3lf1x 208 15 a a DT cord-016652-x8t3lf1x 208 16 twofold twofold NN cord-016652-x8t3lf1x 208 17 or or CC cord-016652-x8t3lf1x 208 18 greater great JJR cord-016652-x8t3lf1x 208 19 change change NN cord-016652-x8t3lf1x 208 20 compared compare VBN cord-016652-x8t3lf1x 208 21 to to IN cord-016652-x8t3lf1x 208 22 almost almost RB cord-016652-x8t3lf1x 208 23 a a DT cord-016652-x8t3lf1x 208 24 third third NN cord-016652-x8t3lf1x 208 25 of of IN cord-016652-x8t3lf1x 208 26 nucleolar nucleolar JJ cord-016652-x8t3lf1x 208 27 antigens antigen NNS cord-016652-x8t3lf1x 208 28 showing show VBG cord-016652-x8t3lf1x 208 29 a a DT cord-016652-x8t3lf1x 208 30 greater great JJR cord-016652-x8t3lf1x 208 31 than than IN cord-016652-x8t3lf1x 208 32 twofold twofold JJ cord-016652-x8t3lf1x 208 33 change change NN cord-016652-x8t3lf1x 208 34 when when WRB cord-016652-x8t3lf1x 208 35 cells cell NNS cord-016652-x8t3lf1x 208 36 are be VBP cord-016652-x8t3lf1x 208 37 treated treat VBN cord-016652-x8t3lf1x 208 38 with with IN cord-016652-x8t3lf1x 208 39 ActD ActD NNP cord-016652-x8t3lf1x 208 40 which which WDT cord-016652-x8t3lf1x 208 41 inhibits inhibit VBZ cord-016652-x8t3lf1x 208 42 rRNA rrna JJ cord-016652-x8t3lf1x 208 43 synthesis synthesis NN cord-016652-x8t3lf1x 208 44 ( ( -LRB- cord-016652-x8t3lf1x 208 45 Lam Lam NNP cord-016652-x8t3lf1x 208 46 et et FW cord-016652-x8t3lf1x 208 47 al al NNP cord-016652-x8t3lf1x 208 48 . . NNP cord-016652-x8t3lf1x 208 49 2010 2010 CD cord-016652-x8t3lf1x 208 50 ) ) -RRB- cord-016652-x8t3lf1x 208 51 . . . cord-016652-x8t3lf1x 209 1 What what WP cord-016652-x8t3lf1x 209 2 is be VBZ cord-016652-x8t3lf1x 209 3 notable notable JJ cord-016652-x8t3lf1x 209 4 is be VBZ cord-016652-x8t3lf1x 209 5 that that IN cord-016652-x8t3lf1x 209 6 direct direct JJ cord-016652-x8t3lf1x 209 7 comparison comparison NN cord-016652-x8t3lf1x 209 8 between between IN cord-016652-x8t3lf1x 209 9 the the DT cord-016652-x8t3lf1x 209 10 adenovirus adenovirus NN cord-016652-x8t3lf1x 209 11 data datum NNS cord-016652-x8t3lf1x 209 12 set set VBN cord-016652-x8t3lf1x 209 13 and and CC cord-016652-x8t3lf1x 209 14 the the DT cord-016652-x8t3lf1x 209 15 ActD ActD NNP cord-016652-x8t3lf1x 209 16 dataset dataset NN cord-016652-x8t3lf1x 209 17 shows show VBZ cord-016652-x8t3lf1x 209 18 no no DT cord-016652-x8t3lf1x 209 19 clear clear JJ cord-016652-x8t3lf1x 209 20 correlation correlation NN cord-016652-x8t3lf1x 209 21 Lam Lam NNP cord-016652-x8t3lf1x 209 22 et et FW cord-016652-x8t3lf1x 209 23 al al NNP cord-016652-x8t3lf1x 209 24 . . NNP cord-016652-x8t3lf1x 209 25 2010 2010 CD cord-016652-x8t3lf1x 209 26 ) ) -RRB- cord-016652-x8t3lf1x 209 27 , , , cord-016652-x8t3lf1x 209 28 further further RB cord-016652-x8t3lf1x 209 29 supporting support VBG cord-016652-x8t3lf1x 209 30 the the DT cord-016652-x8t3lf1x 209 31 case case NN cord-016652-x8t3lf1x 209 32 that that IN cord-016652-x8t3lf1x 209 33 adenovirus adenovirus NN cord-016652-x8t3lf1x 209 34 induces induce VBZ cord-016652-x8t3lf1x 209 35 effects effect NNS cord-016652-x8t3lf1x 209 36 on on IN cord-016652-x8t3lf1x 209 37 the the DT cord-016652-x8t3lf1x 209 38 nucleolus nucleolus NN cord-016652-x8t3lf1x 209 39 distinct distinct JJ cord-016652-x8t3lf1x 209 40 from from IN cord-016652-x8t3lf1x 209 41 that that DT cord-016652-x8t3lf1x 209 42 of of IN cord-016652-x8t3lf1x 209 43 a a DT cord-016652-x8t3lf1x 209 44 generalised generalised JJ cord-016652-x8t3lf1x 209 45 , , , cord-016652-x8t3lf1x 209 46 non non JJ cord-016652-x8t3lf1x 209 47 - - JJ cord-016652-x8t3lf1x 209 48 specific specific JJ cord-016652-x8t3lf1x 209 49 shut shut NN cord-016652-x8t3lf1x 209 50 down down RP cord-016652-x8t3lf1x 209 51 of of IN cord-016652-x8t3lf1x 209 52 nucleolar nucleolar JJ cord-016652-x8t3lf1x 209 53 function function NN cord-016652-x8t3lf1x 209 54 . . . cord-016652-x8t3lf1x 210 1 This this DT cord-016652-x8t3lf1x 210 2 fits fit VBZ cord-016652-x8t3lf1x 210 3 well well RB cord-016652-x8t3lf1x 210 4 with with IN cord-016652-x8t3lf1x 210 5 a a DT cord-016652-x8t3lf1x 210 6 previous previous JJ cord-016652-x8t3lf1x 210 7 observation observation NN cord-016652-x8t3lf1x 210 8 that that IN cord-016652-x8t3lf1x 210 9 adenovirus adenovirus NN cord-016652-x8t3lf1x 210 10 infection infection NN cord-016652-x8t3lf1x 210 11 does do VBZ cord-016652-x8t3lf1x 210 12 not not RB cord-016652-x8t3lf1x 210 13 affect affect VB cord-016652-x8t3lf1x 210 14 rRNA rRNA NNP cord-016652-x8t3lf1x 210 15 synthesis synthesis NN cord-016652-x8t3lf1x 210 16 even even RB cord-016652-x8t3lf1x 210 17 36 36 CD cord-016652-x8t3lf1x 210 18 h h NN cord-016652-x8t3lf1x 210 19 post post NN cord-016652-x8t3lf1x 210 20 - - NN cord-016652-x8t3lf1x 210 21 infection infection JJ cord-016652-x8t3lf1x 211 1 ( ( -LRB- cord-016652-x8t3lf1x 211 2 Lawrence Lawrence NNP cord-016652-x8t3lf1x 211 3 et et NNP cord-016652-x8t3lf1x 211 4 al al NNP cord-016652-x8t3lf1x 211 5 . . . cord-016652-x8t3lf1x 211 6 2006 2006 CD cord-016652-x8t3lf1x 211 7 ) ) -RRB- cord-016652-x8t3lf1x 211 8 . . . cord-016652-x8t3lf1x 212 1 These these DT cord-016652-x8t3lf1x 212 2 results result NNS cord-016652-x8t3lf1x 212 3 were be VBD cord-016652-x8t3lf1x 212 4 initially initially RB cord-016652-x8t3lf1x 212 5 surprising surprising JJ cord-016652-x8t3lf1x 212 6 given give VBN cord-016652-x8t3lf1x 212 7 the the DT cord-016652-x8t3lf1x 212 8 number number NN cord-016652-x8t3lf1x 212 9 of of IN cord-016652-x8t3lf1x 212 10 different different JJ cord-016652-x8t3lf1x 212 11 viral viral JJ cord-016652-x8t3lf1x 212 12 proteins protein NNS cord-016652-x8t3lf1x 212 13 that that WDT cord-016652-x8t3lf1x 212 14 can can MD cord-016652-x8t3lf1x 212 15 localise localise VB cord-016652-x8t3lf1x 212 16 to to IN cord-016652-x8t3lf1x 212 17 this this DT cord-016652-x8t3lf1x 212 18 structure structure NN cord-016652-x8t3lf1x 212 19 and and CC cord-016652-x8t3lf1x 212 20 how how WRB cord-016652-x8t3lf1x 212 21 they -PRON- PRP cord-016652-x8t3lf1x 212 22 interact interact VBP cord-016652-x8t3lf1x 212 23 with with IN cord-016652-x8t3lf1x 212 24 nucleolar nucleolar JJ cord-016652-x8t3lf1x 212 25 proteins protein NNS cord-016652-x8t3lf1x 212 26 . . . cord-016652-x8t3lf1x 213 1 This this DT cord-016652-x8t3lf1x 213 2 suggests suggest VBZ cord-016652-x8t3lf1x 213 3 that that IN cord-016652-x8t3lf1x 213 4 the the DT cord-016652-x8t3lf1x 213 5 nucleolar nucleolar JJ cord-016652-x8t3lf1x 213 6 proteome proteome NN cord-016652-x8t3lf1x 213 7 and and CC cord-016652-x8t3lf1x 213 8 architecture architecture NN cord-016652-x8t3lf1x 213 9 is be VBZ cord-016652-x8t3lf1x 213 10 resilient resilient JJ cord-016652-x8t3lf1x 213 11 during during IN cord-016652-x8t3lf1x 213 12 early early JJ cord-016652-x8t3lf1x 213 13 stages stage NNS cord-016652-x8t3lf1x 213 14 of of IN cord-016652-x8t3lf1x 213 15 infection infection NN cord-016652-x8t3lf1x 213 16 but but CC cord-016652-x8t3lf1x 213 17 may may MD cord-016652-x8t3lf1x 213 18 become become VB cord-016652-x8t3lf1x 213 19 disrupted disrupt VBN cord-016652-x8t3lf1x 213 20 as as IN cord-016652-x8t3lf1x 213 21 more more JJR cord-016652-x8t3lf1x 213 22 and and CC cord-016652-x8t3lf1x 213 23 more more JJR cord-016652-x8t3lf1x 213 24 damage damage NN cord-016652-x8t3lf1x 213 25 accumulates accumulate VBZ cord-016652-x8t3lf1x 213 26 inside inside IN cord-016652-x8t3lf1x 213 27 cells cell NNS cord-016652-x8t3lf1x 213 28 because because IN cord-016652-x8t3lf1x 213 29 of of IN cord-016652-x8t3lf1x 213 30 virus virus NN cord-016652-x8t3lf1x 213 31 activity activity NN cord-016652-x8t3lf1x 213 32 , , , cord-016652-x8t3lf1x 213 33 as as IN cord-016652-x8t3lf1x 213 34 clearly clearly RB cord-016652-x8t3lf1x 213 35 evidenced evidence VBN cord-016652-x8t3lf1x 213 36 in in IN cord-016652-x8t3lf1x 213 37 live live JJ cord-016652-x8t3lf1x 213 38 - - HYPH cord-016652-x8t3lf1x 213 39 cell cell NN cord-016652-x8t3lf1x 213 40 imaging imaging NN cord-016652-x8t3lf1x 213 41 experiments experiment NNS cord-016652-x8t3lf1x 213 42 ( ( -LRB- cord-016652-x8t3lf1x 213 43 Bertrand Bertrand NNP cord-016652-x8t3lf1x 213 44 and and CC cord-016652-x8t3lf1x 213 45 Pearson Pearson NNP cord-016652-x8t3lf1x 213 46 2008 2008 CD cord-016652-x8t3lf1x 213 47 ; ; : cord-016652-x8t3lf1x 214 1 Dove Dove NNP cord-016652-x8t3lf1x 214 2 et et FW cord-016652-x8t3lf1x 214 3 al al NNP cord-016652-x8t3lf1x 214 4 . . . cord-016652-x8t3lf1x 215 1 2006b 2006b CD cord-016652-x8t3lf1x 215 2 ; ; : cord-016652-x8t3lf1x 215 3 ) ) -RRB- cord-016652-x8t3lf1x 215 4 . . . cord-016652-x8t3lf1x 216 1 Coupling couple VBG cord-016652-x8t3lf1x 216 2 quantitative quantitative JJ cord-016652-x8t3lf1x 216 3 proteomic proteomic JJ cord-016652-x8t3lf1x 216 4 analysis analysis NN cord-016652-x8t3lf1x 216 5 of of IN cord-016652-x8t3lf1x 216 6 the the DT cord-016652-x8t3lf1x 216 7 nucleolus nucleolus NN cord-016652-x8t3lf1x 216 8 and and CC cord-016652-x8t3lf1x 216 9 deep deep JJ cord-016652-x8t3lf1x 216 10 sequencing sequencing NN cord-016652-x8t3lf1x 216 11 throughout throughout IN cord-016652-x8t3lf1x 216 12 infection infection NN cord-016652-x8t3lf1x 216 13 in in IN cord-016652-x8t3lf1x 216 14 time time NN cord-016652-x8t3lf1x 216 15 - - HYPH cord-016652-x8t3lf1x 216 16 course course NN cord-016652-x8t3lf1x 216 17 experiments experiment NNS cord-016652-x8t3lf1x 216 18 of of IN cord-016652-x8t3lf1x 216 19 lytic lytic JJ cord-016652-x8t3lf1x 216 20 , , , cord-016652-x8t3lf1x 216 21 latent latent JJ cord-016652-x8t3lf1x 216 22 , , , cord-016652-x8t3lf1x 216 23 acute acute JJ cord-016652-x8t3lf1x 216 24 and and CC cord-016652-x8t3lf1x 216 25 persistent persistent JJ cord-016652-x8t3lf1x 216 26 viruses virus NNS cord-016652-x8t3lf1x 216 27 would would MD cord-016652-x8t3lf1x 216 28 reveal reveal VB cord-016652-x8t3lf1x 216 29 valuable valuable JJ cord-016652-x8t3lf1x 216 30 insights insight NNS cord-016652-x8t3lf1x 216 31 into into IN cord-016652-x8t3lf1x 216 32 the the DT cord-016652-x8t3lf1x 216 33 response response NN cord-016652-x8t3lf1x 216 34 of of IN cord-016652-x8t3lf1x 216 35 the the DT cord-016652-x8t3lf1x 216 36 nucleolus nucleolus NN cord-016652-x8t3lf1x 216 37 to to IN cord-016652-x8t3lf1x 216 38 virus virus NN cord-016652-x8t3lf1x 216 39 infection infection NN cord-016652-x8t3lf1x 216 40 . . . cord-016652-x8t3lf1x 217 1 Likewise likewise RB cord-016652-x8t3lf1x 217 2 , , , cord-016652-x8t3lf1x 217 3 being be VBG cord-016652-x8t3lf1x 217 4 able able JJ cord-016652-x8t3lf1x 217 5 to to TO cord-016652-x8t3lf1x 217 6 move move VB cord-016652-x8t3lf1x 217 7 from from IN cord-016652-x8t3lf1x 217 8 studying study VBG cord-016652-x8t3lf1x 217 9 cell cell NN cord-016652-x8t3lf1x 217 10 culture culture NN cord-016652-x8t3lf1x 217 11 - - HYPH cord-016652-x8t3lf1x 217 12 adapted adapt VBN cord-016652-x8t3lf1x 217 13 laboratory laboratory NN cord-016652-x8t3lf1x 217 14 strains strain NNS cord-016652-x8t3lf1x 217 15 into into IN cord-016652-x8t3lf1x 217 16 clinical clinical JJ cord-016652-x8t3lf1x 217 17 isolates isolate NNS cord-016652-x8t3lf1x 217 18 replicating replicate VBG cord-016652-x8t3lf1x 217 19 in in IN cord-016652-x8t3lf1x 217 20 primary primary JJ cord-016652-x8t3lf1x 217 21 cells cell NNS cord-016652-x8t3lf1x 217 22 would would MD cord-016652-x8t3lf1x 217 23 yield yield VB cord-016652-x8t3lf1x 217 24 more more RBR cord-016652-x8t3lf1x 217 25 biologically biologically RB cord-016652-x8t3lf1x 217 26 relevant relevant JJ cord-016652-x8t3lf1x 217 27 information information NN cord-016652-x8t3lf1x 217 28 , , , cord-016652-x8t3lf1x 217 29 particularly particularly RB cord-016652-x8t3lf1x 217 30 with with IN cord-016652-x8t3lf1x 217 31 regard regard NN cord-016652-x8t3lf1x 217 32 to to IN cord-016652-x8t3lf1x 217 33 the the DT cord-016652-x8t3lf1x 217 34 severity severity NN cord-016652-x8t3lf1x 217 35 of of IN cord-016652-x8t3lf1x 217 36 disease disease NN cord-016652-x8t3lf1x 217 37 and and CC cord-016652-x8t3lf1x 217 38 nucleolar nucleolar JJ cord-016652-x8t3lf1x 217 39 changes change NNS cord-016652-x8t3lf1x 217 40 . . . cord-016652-x8t3lf1x 218 1 These these DT cord-016652-x8t3lf1x 218 2 technologies technology NNS cord-016652-x8t3lf1x 218 3 could could MD cord-016652-x8t3lf1x 218 4 also also RB cord-016652-x8t3lf1x 218 5 be be VB cord-016652-x8t3lf1x 218 6 applied apply VBN cord-016652-x8t3lf1x 218 7 to to IN cord-016652-x8t3lf1x 218 8 large large JJ cord-016652-x8t3lf1x 218 9 - - HYPH cord-016652-x8t3lf1x 218 10 scale scale NN cord-016652-x8t3lf1x 218 11 analysis analysis NN cord-016652-x8t3lf1x 218 12 of of IN cord-016652-x8t3lf1x 218 13 viral viral JJ cord-016652-x8t3lf1x 218 14 proteins protein NNS cord-016652-x8t3lf1x 218 15 that that WDT cord-016652-x8t3lf1x 218 16 traffic traffic NN cord-016652-x8t3lf1x 218 17 to to IN cord-016652-x8t3lf1x 218 18 the the DT cord-016652-x8t3lf1x 218 19 nucleolus nucleolus NN cord-016652-x8t3lf1x 218 20 and and CC cord-016652-x8t3lf1x 218 21 the the DT cord-016652-x8t3lf1x 218 22 cellular cellular JJ cord-016652-x8t3lf1x 218 23 nucleolar nucleolar JJ cord-016652-x8t3lf1x 218 24 proteins protein NNS cord-016652-x8t3lf1x 218 25 that that IN cord-016652-x8t3lf1x 218 26 they -PRON- PRP cord-016652-x8t3lf1x 218 27 associate associate VBP cord-016652-x8t3lf1x 218 28 with with IN cord-016652-x8t3lf1x 218 29 ( ( -LRB- cord-016652-x8t3lf1x 218 30 e.g. e.g. RB cord-016652-x8t3lf1x 218 31 using use VBG cord-016652-x8t3lf1x 218 32 SILAC SILAC NNP cord-016652-x8t3lf1x 218 33 and and CC cord-016652-x8t3lf1x 218 34 EGFP EGFP NNP cord-016652-x8t3lf1x 218 35 - - HYPH cord-016652-x8t3lf1x 218 36 traps trap NNS cord-016652-x8t3lf1x 219 1 ( ( -LRB- cord-016652-x8t3lf1x 219 2 Trinkle Trinkle NNP cord-016652-x8t3lf1x 219 3 - - HYPH cord-016652-x8t3lf1x 219 4 Mulcahy Mulcahy NNP cord-016652-x8t3lf1x 219 5 et et NNP cord-016652-x8t3lf1x 219 6 al al NNP cord-016652-x8t3lf1x 219 7 . . NNP cord-016652-x8t3lf1x 219 8 2008 2008 CD cord-016652-x8t3lf1x 219 9 ) ) -RRB- cord-016652-x8t3lf1x 219 10 ) ) -RRB- cord-016652-x8t3lf1x 219 11 , , , cord-016652-x8t3lf1x 219 12 thus thus RB cord-016652-x8t3lf1x 219 13 generating generate VBG cord-016652-x8t3lf1x 219 14 and and CC cord-016652-x8t3lf1x 219 15 integrating integrate VBG cord-016652-x8t3lf1x 219 16 interactome interactome NN cord-016652-x8t3lf1x 219 17 networks network NNS cord-016652-x8t3lf1x 219 18 with with IN cord-016652-x8t3lf1x 219 19 the the DT cord-016652-x8t3lf1x 219 20 nucleolar nucleolar JJ cord-016652-x8t3lf1x 219 21 proteome proteome NN cord-016652-x8t3lf1x 219 22 during during IN cord-016652-x8t3lf1x 219 23 infection infection NN cord-016652-x8t3lf1x 219 24 . . . cord-016652-x8t3lf1x 220 1 NOPdb nopdb NN cord-016652-x8t3lf1x 220 2 : : : cord-016652-x8t3lf1x 221 1 nucleolar nucleolar NNP cord-016652-x8t3lf1x 221 2 proteome proteome NNP cord-016652-x8t3lf1x 221 3 database-2008 database-2008 NNP cord-016652-x8t3lf1x 221 4 update update NN cord-016652-x8t3lf1x 221 5 Encephalomyocarditis Encephalomyocarditis NNP cord-016652-x8t3lf1x 221 6 viral viral JJ cord-016652-x8t3lf1x 221 7 protein protein NN cord-016652-x8t3lf1x 221 8 2A 2a CD cord-016652-x8t3lf1x 221 9 localizes localize VBZ cord-016652-x8t3lf1x 221 10 to to IN cord-016652-x8t3lf1x 221 11 nucleoli nucleoli NNP cord-016652-x8t3lf1x 221 12 and and CC cord-016652-x8t3lf1x 221 13 inhibits inhibit VBZ cord-016652-x8t3lf1x 221 14 cap cap NN cord-016652-x8t3lf1x 221 15 - - HYPH cord-016652-x8t3lf1x 221 16 dependent dependent JJ cord-016652-x8t3lf1x 222 1 mRNA mrna NN cord-016652-x8t3lf1x 222 2 translation translation NN cord-016652-x8t3lf1x 222 3 Encephalomyocarditis Encephalomyocarditis NNP cord-016652-x8t3lf1x 222 4 virus virus NN cord-016652-x8t3lf1x 222 5 ( ( -LRB- cord-016652-x8t3lf1x 222 6 EMCV EMCV NNP cord-016652-x8t3lf1x 222 7 ) ) -RRB- cord-016652-x8t3lf1x 222 8 proteins protein VBZ cord-016652-x8t3lf1x 222 9 2A 2a CD cord-016652-x8t3lf1x 222 10 and and CC cord-016652-x8t3lf1x 222 11 3BCD 3BCD NNS cord-016652-x8t3lf1x 222 12 localize localize VB cord-016652-x8t3lf1x 222 13 to to IN cord-016652-x8t3lf1x 222 14 nuclei nucleus NNS cord-016652-x8t3lf1x 222 15 and and CC cord-016652-x8t3lf1x 222 16 inhibit inhibit VB cord-016652-x8t3lf1x 222 17 cellular cellular JJ cord-016652-x8t3lf1x 222 18 mRNA mrna NN cord-016652-x8t3lf1x 222 19 transcription transcription NN cord-016652-x8t3lf1x 222 20 but but CC cord-016652-x8t3lf1x 222 21 not not RB cord-016652-x8t3lf1x 222 22 rRNA rrna NN cord-016652-x8t3lf1x 222 23 transcription transcription NN cord-016652-x8t3lf1x 222 24 Rhinovirus Rhinovirus NNP cord-016652-x8t3lf1x 222 25 3 3 CD cord-016652-x8t3lf1x 222 26 C C NNP cord-016652-x8t3lf1x 222 27 protease protease NN cord-016652-x8t3lf1x 222 28 precursors precursor NNS cord-016652-x8t3lf1x 222 29 3CD 3CD NNP cord-016652-x8t3lf1x 222 30 and and CC cord-016652-x8t3lf1x 222 31 3CD 3CD NNP cord-016652-x8t3lf1x 222 32 ' ' '' cord-016652-x8t3lf1x 222 33 localize localize NN cord-016652-x8t3lf1x 222 34 to to IN cord-016652-x8t3lf1x 222 35 the the DT cord-016652-x8t3lf1x 222 36 nuclei nucleus NNS cord-016652-x8t3lf1x 222 37 of of IN cord-016652-x8t3lf1x 222 38 infected infected JJ cord-016652-x8t3lf1x 222 39 cells cell NNS cord-016652-x8t3lf1x 223 1 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 223 2 proteome proteome NN cord-016652-x8t3lf1x 223 3 dynamics dynamic NNS cord-016652-x8t3lf1x 223 4 Human human JJ cord-016652-x8t3lf1x 223 5 cytomegalovirus cytomegalovirus NN cord-016652-x8t3lf1x 223 6 proteins protein NNS cord-016652-x8t3lf1x 223 7 PP65 PP65 NNP cord-016652-x8t3lf1x 223 8 and and CC cord-016652-x8t3lf1x 223 9 IEP72 IEP72 NNP cord-016652-x8t3lf1x 223 10 are be VBP cord-016652-x8t3lf1x 223 11 targeted target VBN cord-016652-x8t3lf1x 223 12 to to IN cord-016652-x8t3lf1x 223 13 distinct distinct JJ cord-016652-x8t3lf1x 223 14 compartments compartment NNS cord-016652-x8t3lf1x 223 15 in in IN cord-016652-x8t3lf1x 223 16 nuclei nucleus NNS cord-016652-x8t3lf1x 223 17 and and CC cord-016652-x8t3lf1x 223 18 nuclear nuclear JJ cord-016652-x8t3lf1x 223 19 matrices matrix NNS cord-016652-x8t3lf1x 223 20 of of IN cord-016652-x8t3lf1x 223 21 infected infected JJ cord-016652-x8t3lf1x 223 22 human human JJ cord-016652-x8t3lf1x 223 23 embryo embryo NN cord-016652-x8t3lf1x 223 24 fibroblasts fibroblast VBZ cord-016652-x8t3lf1x 223 25 Cell cell NN cord-016652-x8t3lf1x 223 26 - - HYPH cord-016652-x8t3lf1x 223 27 cycle cycle NN cord-016652-x8t3lf1x 223 28 - - HYPH cord-016652-x8t3lf1x 223 29 dependent dependent JJ cord-016652-x8t3lf1x 223 30 localization localization NN cord-016652-x8t3lf1x 223 31 of of IN cord-016652-x8t3lf1x 223 32 human human JJ cord-016652-x8t3lf1x 223 33 cytomegalovirus cytomegalovirus NN cord-016652-x8t3lf1x 223 34 UL83 UL83 NNP cord-016652-x8t3lf1x 223 35 phosphoprotein phosphoprotein NN cord-016652-x8t3lf1x 223 36 in in IN cord-016652-x8t3lf1x 223 37 the the DT cord-016652-x8t3lf1x 223 38 nucleolus nucleolus NN cord-016652-x8t3lf1x 223 39 and and CC cord-016652-x8t3lf1x 223 40 modulation modulation NN cord-016652-x8t3lf1x 223 41 of of IN cord-016652-x8t3lf1x 223 42 viral viral JJ cord-016652-x8t3lf1x 223 43 gene gene NN cord-016652-x8t3lf1x 223 44 expression expression NN cord-016652-x8t3lf1x 223 45 in in IN cord-016652-x8t3lf1x 223 46 human human JJ cord-016652-x8t3lf1x 223 47 embryo embryo NN cord-016652-x8t3lf1x 223 48 fibroblasts fibroblast NNS cord-016652-x8t3lf1x 223 49 in in IN cord-016652-x8t3lf1x 223 50 vitro vitro FW cord-016652-x8t3lf1x 223 51 Np9 Np9 NNP cord-016652-x8t3lf1x 223 52 protein protein NN cord-016652-x8t3lf1x 223 53 of of IN cord-016652-x8t3lf1x 223 54 human human JJ cord-016652-x8t3lf1x 223 55 endogenous endogenous JJ cord-016652-x8t3lf1x 223 56 retrovirus retrovirus NN cord-016652-x8t3lf1x 223 57 K K NNP cord-016652-x8t3lf1x 223 58 interacts interact VBZ cord-016652-x8t3lf1x 223 59 with with IN cord-016652-x8t3lf1x 223 60 ligand ligand NN cord-016652-x8t3lf1x 223 61 of of IN cord-016652-x8t3lf1x 223 62 numb numb JJ cord-016652-x8t3lf1x 223 63 protein protein NN cord-016652-x8t3lf1x 223 64 X X NNP cord-016652-x8t3lf1x 223 65 Functional functional JJ cord-016652-x8t3lf1x 223 66 role role NN cord-016652-x8t3lf1x 223 67 of of IN cord-016652-x8t3lf1x 223 68 pX px DT cord-016652-x8t3lf1x 223 69 open open JJ cord-016652-x8t3lf1x 223 70 reading reading NN cord-016652-x8t3lf1x 223 71 frame frame NN cord-016652-x8t3lf1x 223 72 II ii CD cord-016652-x8t3lf1x 223 73 of of IN cord-016652-x8t3lf1x 223 74 human human NNP cord-016652-x8t3lf1x 223 75 T T NNP cord-016652-x8t3lf1x 223 76 - - HYPH cord-016652-x8t3lf1x 223 77 lymphotropic lymphotropic NNP cord-016652-x8t3lf1x 223 78 virus virus NN cord-016652-x8t3lf1x 223 79 type type NN cord-016652-x8t3lf1x 223 80 1 1 CD cord-016652-x8t3lf1x 223 81 in in IN cord-016652-x8t3lf1x 223 82 maintenance maintenance NN cord-016652-x8t3lf1x 223 83 of of IN cord-016652-x8t3lf1x 223 84 viral viral JJ cord-016652-x8t3lf1x 223 85 loads load NNS cord-016652-x8t3lf1x 223 86 in in IN cord-016652-x8t3lf1x 223 87 vivo vivo NN cord-016652-x8t3lf1x 224 1 A a DT cord-016652-x8t3lf1x 224 2 temporal temporal JJ cord-016652-x8t3lf1x 224 3 study study NN cord-016652-x8t3lf1x 224 4 of of IN cord-016652-x8t3lf1x 224 5 the the DT cord-016652-x8t3lf1x 224 6 expression expression NN cord-016652-x8t3lf1x 224 7 of of IN cord-016652-x8t3lf1x 224 8 the the DT cord-016652-x8t3lf1x 224 9 capsid capsid JJ cord-016652-x8t3lf1x 224 10 , , , cord-016652-x8t3lf1x 224 11 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 224 12 inclusion inclusion NN cord-016652-x8t3lf1x 224 13 and and CC cord-016652-x8t3lf1x 224 14 nuclear nuclear JJ cord-016652-x8t3lf1x 224 15 inclusion inclusion NN cord-016652-x8t3lf1x 224 16 proteins protein NNS cord-016652-x8t3lf1x 224 17 of of IN cord-016652-x8t3lf1x 224 18 tobacco tobacco NN cord-016652-x8t3lf1x 224 19 etch etch NNP cord-016652-x8t3lf1x 224 20 potyvirus potyvirus NNP cord-016652-x8t3lf1x 224 21 in in IN cord-016652-x8t3lf1x 224 22 infected infected JJ cord-016652-x8t3lf1x 224 23 plants plant NNS cord-016652-x8t3lf1x 224 24 Visualization visualization NN cord-016652-x8t3lf1x 224 25 of of IN cord-016652-x8t3lf1x 224 26 the the DT cord-016652-x8t3lf1x 224 27 interaction interaction NN cord-016652-x8t3lf1x 224 28 between between IN cord-016652-x8t3lf1x 224 29 the the DT cord-016652-x8t3lf1x 224 30 precursors precursor NNS cord-016652-x8t3lf1x 224 31 of of IN cord-016652-x8t3lf1x 224 32 VPg VPg NNS cord-016652-x8t3lf1x 224 33 , , , cord-016652-x8t3lf1x 224 34 the the DT cord-016652-x8t3lf1x 224 35 viral viral JJ cord-016652-x8t3lf1x 224 36 protein protein NN cord-016652-x8t3lf1x 224 37 linked link VBN cord-016652-x8t3lf1x 224 38 to to IN cord-016652-x8t3lf1x 224 39 the the DT cord-016652-x8t3lf1x 224 40 genome genome NN cord-016652-x8t3lf1x 224 41 of of IN cord-016652-x8t3lf1x 224 42 turnip turnip NN cord-016652-x8t3lf1x 224 43 mosaic mosaic JJ cord-016652-x8t3lf1x 224 44 virus virus NN cord-016652-x8t3lf1x 224 45 , , , cord-016652-x8t3lf1x 224 46 and and CC cord-016652-x8t3lf1x 224 47 the the DT cord-016652-x8t3lf1x 224 48 translation translation NN cord-016652-x8t3lf1x 224 49 eukaryotic eukaryotic JJ cord-016652-x8t3lf1x 224 50 initiation initiation NN cord-016652-x8t3lf1x 224 51 factor factor NN cord-016652-x8t3lf1x 224 52 iso iso NNP cord-016652-x8t3lf1x 224 53 4E 4e NN cord-016652-x8t3lf1x 224 54 in in IN cord-016652-x8t3lf1x 224 55 Planta Planta NNP cord-016652-x8t3lf1x 225 1 The the DT cord-016652-x8t3lf1x 225 2 conserved conserved JJ cord-016652-x8t3lf1x 225 3 N n CD cord-016652-x8t3lf1x 225 4 - - HYPH cord-016652-x8t3lf1x 225 5 terminal terminal NN cord-016652-x8t3lf1x 225 6 domain domain NN cord-016652-x8t3lf1x 225 7 of of IN cord-016652-x8t3lf1x 225 8 herpes herpes NNP cord-016652-x8t3lf1x 225 9 simplex simplex NN cord-016652-x8t3lf1x 225 10 virus virus NN cord-016652-x8t3lf1x 225 11 1 1 CD cord-016652-x8t3lf1x 225 12 UL24 UL24 NNP cord-016652-x8t3lf1x 225 13 protein protein NN cord-016652-x8t3lf1x 225 14 is be VBZ cord-016652-x8t3lf1x 225 15 sufficient sufficient JJ cord-016652-x8t3lf1x 225 16 to to TO cord-016652-x8t3lf1x 225 17 induce induce VB cord-016652-x8t3lf1x 225 18 the the DT cord-016652-x8t3lf1x 225 19 spatial spatial JJ cord-016652-x8t3lf1x 225 20 redistribution redistribution NN cord-016652-x8t3lf1x 225 21 of of IN cord-016652-x8t3lf1x 225 22 nucleolin nucleolin NNP cord-016652-x8t3lf1x 225 23 M148R M148R NNP cord-016652-x8t3lf1x 225 24 and and CC cord-016652-x8t3lf1x 225 25 M149R M149R NNP cord-016652-x8t3lf1x 225 26 are be VBP cord-016652-x8t3lf1x 225 27 two two CD cord-016652-x8t3lf1x 225 28 virulence virulence NN cord-016652-x8t3lf1x 225 29 factors factor NNS cord-016652-x8t3lf1x 225 30 for for IN cord-016652-x8t3lf1x 225 31 myxoma myxoma NNP cord-016652-x8t3lf1x 225 32 virus virus NN cord-016652-x8t3lf1x 225 33 pathogenesis pathogenesis NN cord-016652-x8t3lf1x 225 34 in in IN cord-016652-x8t3lf1x 225 35 the the DT cord-016652-x8t3lf1x 225 36 European european JJ cord-016652-x8t3lf1x 225 37 rabbit rabbit NN cord-016652-x8t3lf1x 226 1 The the DT cord-016652-x8t3lf1x 226 2 nucleolus nucleolus NN cord-016652-x8t3lf1x 226 3 under under IN cord-016652-x8t3lf1x 226 4 stress stress NN cord-016652-x8t3lf1x 227 1 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 227 2 trafficking trafficking NN cord-016652-x8t3lf1x 227 3 is be VBZ cord-016652-x8t3lf1x 227 4 essential essential JJ cord-016652-x8t3lf1x 227 5 for for IN cord-016652-x8t3lf1x 227 6 nuclear nuclear JJ cord-016652-x8t3lf1x 227 7 export export NN cord-016652-x8t3lf1x 227 8 of of IN cord-016652-x8t3lf1x 227 9 intronless intronless NN cord-016652-x8t3lf1x 227 10 herpesvirus herpesvirus NNP cord-016652-x8t3lf1x 227 11 mRNA mRNA NNP cord-016652-x8t3lf1x 227 12 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 227 13 disruption disruption NN cord-016652-x8t3lf1x 227 14 impairs impair VBZ cord-016652-x8t3lf1x 228 1 Kaposi Kaposi NNP cord-016652-x8t3lf1x 228 2 's 's POS cord-016652-x8t3lf1x 228 3 sarcoma sarcoma NN cord-016652-x8t3lf1x 228 4 - - HYPH cord-016652-x8t3lf1x 228 5 associated associate VBN cord-016652-x8t3lf1x 228 6 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 228 7 ORF57-mediated orf57-mediate VBN cord-016652-x8t3lf1x 228 8 nuclear nuclear JJ cord-016652-x8t3lf1x 228 9 export export NN cord-016652-x8t3lf1x 228 10 of of IN cord-016652-x8t3lf1x 228 11 intronless intronless JJ cord-016652-x8t3lf1x 228 12 viral viral NN cord-016652-x8t3lf1x 228 13 mRNAs mRNAs . cord-016652-x8t3lf1x 229 1 Herpesvirus Herpesvirus NNP cord-016652-x8t3lf1x 229 2 saimiri saimiri NNP cord-016652-x8t3lf1x 230 1 ORF57 ORF57 NNP cord-016652-x8t3lf1x 230 2 : : : cord-016652-x8t3lf1x 231 1 a a DT cord-016652-x8t3lf1x 231 2 post post JJ cord-016652-x8t3lf1x 231 3 - - JJ cord-016652-x8t3lf1x 231 4 transcriptional transcriptional JJ cord-016652-x8t3lf1x 231 5 regulatory regulatory JJ cord-016652-x8t3lf1x 231 6 protein protein NN cord-016652-x8t3lf1x 231 7 Recruitment Recruitment NNP cord-016652-x8t3lf1x 231 8 of of IN cord-016652-x8t3lf1x 231 9 the the DT cord-016652-x8t3lf1x 231 10 complete complete JJ cord-016652-x8t3lf1x 231 11 hTREX htrex NN cord-016652-x8t3lf1x 231 12 complex complex NN cord-016652-x8t3lf1x 231 13 is be VBZ cord-016652-x8t3lf1x 231 14 required require VBN cord-016652-x8t3lf1x 231 15 for for IN cord-016652-x8t3lf1x 231 16 Kaposi Kaposi NNP cord-016652-x8t3lf1x 231 17 's 's POS cord-016652-x8t3lf1x 231 18 sarcoma sarcoma NN cord-016652-x8t3lf1x 231 19 - - HYPH cord-016652-x8t3lf1x 231 20 associated associate VBN cord-016652-x8t3lf1x 231 21 herpesvirus herpesvirus NNP cord-016652-x8t3lf1x 231 22 intronless intronless NNP cord-016652-x8t3lf1x 231 23 mRNA mRNA NNP cord-016652-x8t3lf1x 231 24 nuclear nuclear JJ cord-016652-x8t3lf1x 231 25 export export NN cord-016652-x8t3lf1x 231 26 and and CC cord-016652-x8t3lf1x 231 27 virus virus NN cord-016652-x8t3lf1x 231 28 replication replication NN cord-016652-x8t3lf1x 231 29 Kaposi Kaposi NNP cord-016652-x8t3lf1x 231 30 's 's POS cord-016652-x8t3lf1x 231 31 sarcoma sarcoma NN cord-016652-x8t3lf1x 231 32 - - HYPH cord-016652-x8t3lf1x 231 33 associated associate VBN cord-016652-x8t3lf1x 231 34 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 231 35 ORF57 ORF57 NNP cord-016652-x8t3lf1x 231 36 protein protein NN cord-016652-x8t3lf1x 231 37 interacts interact VBZ cord-016652-x8t3lf1x 231 38 with with IN cord-016652-x8t3lf1x 231 39 PYM PYM NNP cord-016652-x8t3lf1x 231 40 to to TO cord-016652-x8t3lf1x 231 41 enhance enhance VB cord-016652-x8t3lf1x 231 42 translation translation NN cord-016652-x8t3lf1x 231 43 of of IN cord-016652-x8t3lf1x 231 44 viral viral JJ cord-016652-x8t3lf1x 231 45 intronless intronless NN cord-016652-x8t3lf1x 231 46 mRNAs mRNAs . cord-016652-x8t3lf1x 232 1 Nucleolin Nucleolin NNP cord-016652-x8t3lf1x 232 2 is be VBZ cord-016652-x8t3lf1x 232 3 required require VBN cord-016652-x8t3lf1x 232 4 for for IN cord-016652-x8t3lf1x 232 5 an an DT cord-016652-x8t3lf1x 232 6 efficient efficient JJ cord-016652-x8t3lf1x 232 7 herpes herpes NN cord-016652-x8t3lf1x 232 8 simplex simplex NN cord-016652-x8t3lf1x 232 9 virus virus NN cord-016652-x8t3lf1x 232 10 type type NN cord-016652-x8t3lf1x 232 11 1 1 CD cord-016652-x8t3lf1x 232 12 infection infection NN cord-016652-x8t3lf1x 233 1 HIPK2 hipk2 FW cord-016652-x8t3lf1x 233 2 : : : cord-016652-x8t3lf1x 234 1 a a DT cord-016652-x8t3lf1x 234 2 versatile versatile JJ cord-016652-x8t3lf1x 234 3 switchboard switchboard NN cord-016652-x8t3lf1x 234 4 regulating regulate VBG cord-016652-x8t3lf1x 234 5 the the DT cord-016652-x8t3lf1x 234 6 transcription transcription NN cord-016652-x8t3lf1x 234 7 machinery machinery NN cord-016652-x8t3lf1x 234 8 and and CC cord-016652-x8t3lf1x 234 9 cell cell NN cord-016652-x8t3lf1x 234 10 death death NN cord-016652-x8t3lf1x 234 11 From from IN cord-016652-x8t3lf1x 234 12 top top NN cord-016652-x8t3lf1x 234 13 to to IN cord-016652-x8t3lf1x 234 14 bottom bottom NN cord-016652-x8t3lf1x 234 15 : : : cord-016652-x8t3lf1x 234 16 the the DT cord-016652-x8t3lf1x 234 17 two two CD cord-016652-x8t3lf1x 234 18 faces face NNS cord-016652-x8t3lf1x 234 19 of of IN cord-016652-x8t3lf1x 234 20 HIPK2 hipk2 NN cord-016652-x8t3lf1x 234 21 for for IN cord-016652-x8t3lf1x 234 22 regulation regulation NN cord-016652-x8t3lf1x 234 23 of of IN cord-016652-x8t3lf1x 234 24 the the DT cord-016652-x8t3lf1x 234 25 hypoxic hypoxic JJ cord-016652-x8t3lf1x 234 26 response response NN cord-016652-x8t3lf1x 234 27 Nuclear nuclear JJ cord-016652-x8t3lf1x 234 28 localization localization NN cord-016652-x8t3lf1x 234 29 of of IN cord-016652-x8t3lf1x 234 30 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 234 31 - - HYPH cord-016652-x8t3lf1x 234 32 like like JJ cord-016652-x8t3lf1x 234 33 particles particle NNS cord-016652-x8t3lf1x 234 34 and and CC cord-016652-x8t3lf1x 234 35 HCV HCV NNP cord-016652-x8t3lf1x 234 36 core core NN cord-016652-x8t3lf1x 234 37 protein protein NN cord-016652-x8t3lf1x 234 38 in in IN cord-016652-x8t3lf1x 234 39 hepatocytes hepatocyte NNS cord-016652-x8t3lf1x 234 40 of of IN cord-016652-x8t3lf1x 234 41 a a DT cord-016652-x8t3lf1x 234 42 chronically chronically RB cord-016652-x8t3lf1x 234 43 HCV HCV NNP cord-016652-x8t3lf1x 234 44 - - HYPH cord-016652-x8t3lf1x 234 45 infected infect VBN cord-016652-x8t3lf1x 234 46 patient patient NN cord-016652-x8t3lf1x 235 1 A a DT cord-016652-x8t3lf1x 235 2 single single JJ cord-016652-x8t3lf1x 235 3 amino amino NN cord-016652-x8t3lf1x 235 4 acid acid NN cord-016652-x8t3lf1x 235 5 change change NN cord-016652-x8t3lf1x 235 6 in in IN cord-016652-x8t3lf1x 235 7 the the DT cord-016652-x8t3lf1x 235 8 nuclear nuclear JJ cord-016652-x8t3lf1x 235 9 localization localization NN cord-016652-x8t3lf1x 235 10 sequence sequence NN cord-016652-x8t3lf1x 235 11 of of IN cord-016652-x8t3lf1x 235 12 the the DT cord-016652-x8t3lf1x 235 13 nsP2 nsP2 NNP cord-016652-x8t3lf1x 235 14 protein protein NN cord-016652-x8t3lf1x 235 15 affects affect VBZ cord-016652-x8t3lf1x 235 16 the the DT cord-016652-x8t3lf1x 235 17 neurovirulence neurovirulence NNP cord-016652-x8t3lf1x 235 18 of of IN cord-016652-x8t3lf1x 235 19 semliki semliki NNP cord-016652-x8t3lf1x 235 20 forest forest NNP cord-016652-x8t3lf1x 235 21 virus virus NN cord-016652-x8t3lf1x 235 22 Analysis Analysis NNP cord-016652-x8t3lf1x 235 23 of of IN cord-016652-x8t3lf1x 235 24 the the DT cord-016652-x8t3lf1x 235 25 subcellular subcellular JJ cord-016652-x8t3lf1x 235 26 localization localization NN cord-016652-x8t3lf1x 235 27 of of IN cord-016652-x8t3lf1x 235 28 the the DT cord-016652-x8t3lf1x 235 29 proteins protein NNS cord-016652-x8t3lf1x 235 30 Rep Rep NNP cord-016652-x8t3lf1x 235 31 , , , cord-016652-x8t3lf1x 235 32 Rep Rep NNP cord-016652-x8t3lf1x 235 33 ' ' POS cord-016652-x8t3lf1x 235 34 and and CC cord-016652-x8t3lf1x 235 35 Cap Cap NNP cord-016652-x8t3lf1x 235 36 of of IN cord-016652-x8t3lf1x 235 37 porcine porcine JJ cord-016652-x8t3lf1x 235 38 circovirus circovirus JJ cord-016652-x8t3lf1x 235 39 type type NN cord-016652-x8t3lf1x 235 40 1 1 CD cord-016652-x8t3lf1x 235 41 Bovine bovine JJ cord-016652-x8t3lf1x 235 42 immunodeficiency immunodeficiency NN cord-016652-x8t3lf1x 235 43 virus virus NN cord-016652-x8t3lf1x 235 44 tat tat NN cord-016652-x8t3lf1x 235 45 gene gene NN cord-016652-x8t3lf1x 235 46 : : : cord-016652-x8t3lf1x 236 1 cloning clone VBG cord-016652-x8t3lf1x 236 2 of of IN cord-016652-x8t3lf1x 236 3 two two CD cord-016652-x8t3lf1x 236 4 distinct distinct JJ cord-016652-x8t3lf1x 236 5 cDNAs cdna NNS cord-016652-x8t3lf1x 236 6 and and CC cord-016652-x8t3lf1x 236 7 identification identification NN cord-016652-x8t3lf1x 236 8 , , , cord-016652-x8t3lf1x 236 9 characterization characterization NN cord-016652-x8t3lf1x 236 10 , , , cord-016652-x8t3lf1x 236 11 and and CC cord-016652-x8t3lf1x 236 12 immunolocalization immunolocalization NN cord-016652-x8t3lf1x 236 13 of of IN cord-016652-x8t3lf1x 236 14 the the DT cord-016652-x8t3lf1x 236 15 tat tat NN cord-016652-x8t3lf1x 236 16 gene gene NN cord-016652-x8t3lf1x 236 17 products product NNS cord-016652-x8t3lf1x 236 18 Human Human NNP cord-016652-x8t3lf1x 236 19 T T NNP cord-016652-x8t3lf1x 236 20 - - HYPH cord-016652-x8t3lf1x 236 21 cell cell NN cord-016652-x8t3lf1x 236 22 leukemia leukemia NN cord-016652-x8t3lf1x 236 23 virus virus NN cord-016652-x8t3lf1x 236 24 type type NN cord-016652-x8t3lf1x 236 25 I -PRON- PRP cord-016652-x8t3lf1x 236 26 p30 p30 NNP cord-016652-x8t3lf1x 236 27 nuclear nuclear JJ cord-016652-x8t3lf1x 236 28 / / SYM cord-016652-x8t3lf1x 236 29 nucleolar nucleolar JJ cord-016652-x8t3lf1x 236 30 retention retention NN cord-016652-x8t3lf1x 236 31 is be VBZ cord-016652-x8t3lf1x 236 32 mediated mediate VBN cord-016652-x8t3lf1x 236 33 through through IN cord-016652-x8t3lf1x 236 34 interactions interaction NNS cord-016652-x8t3lf1x 236 35 with with IN cord-016652-x8t3lf1x 236 36 RNA RNA NNP cord-016652-x8t3lf1x 236 37 and and CC cord-016652-x8t3lf1x 236 38 a a DT cord-016652-x8t3lf1x 236 39 constituent constituent NN cord-016652-x8t3lf1x 236 40 of of IN cord-016652-x8t3lf1x 236 41 the the DT cord-016652-x8t3lf1x 236 42 60 60 CD cord-016652-x8t3lf1x 236 43 S S NNP cord-016652-x8t3lf1x 236 44 ribosomal ribosomal NN cord-016652-x8t3lf1x 236 45 subunit subunit NN cord-016652-x8t3lf1x 236 46 US11 US11 NNP cord-016652-x8t3lf1x 236 47 of of IN cord-016652-x8t3lf1x 236 48 herpes herpes NNP cord-016652-x8t3lf1x 236 49 simplex simplex NNP cord-016652-x8t3lf1x 236 50 virus virus NN cord-016652-x8t3lf1x 236 51 type type NN cord-016652-x8t3lf1x 236 52 1 1 CD cord-016652-x8t3lf1x 236 53 interacts interact VBZ cord-016652-x8t3lf1x 236 54 with with IN cord-016652-x8t3lf1x 236 55 HIPK2 HIPK2 NNP cord-016652-x8t3lf1x 236 56 and and CC cord-016652-x8t3lf1x 236 57 antagonizes antagonize VBZ cord-016652-x8t3lf1x 236 58 HIPK2-induced HIPK2-induced NNP cord-016652-x8t3lf1x 236 59 cell cell NN cord-016652-x8t3lf1x 236 60 growth growth NN cord-016652-x8t3lf1x 236 61 arrest arrest NN cord-016652-x8t3lf1x 236 62 Nuclear nuclear JJ cord-016652-x8t3lf1x 236 63 and and CC cord-016652-x8t3lf1x 236 64 nucleolar nucleolar JJ cord-016652-x8t3lf1x 236 65 localization localization NN cord-016652-x8t3lf1x 236 66 of of IN cord-016652-x8t3lf1x 236 67 an an DT cord-016652-x8t3lf1x 236 68 African african JJ cord-016652-x8t3lf1x 236 69 swine swine NN cord-016652-x8t3lf1x 236 70 fever fever NN cord-016652-x8t3lf1x 236 71 virus virus NN cord-016652-x8t3lf1x 236 72 protein protein NN cord-016652-x8t3lf1x 236 73 , , , cord-016652-x8t3lf1x 236 74 I14L I14L NNP cord-016652-x8t3lf1x 236 75 , , , cord-016652-x8t3lf1x 236 76 that that WDT cord-016652-x8t3lf1x 236 77 is be VBZ cord-016652-x8t3lf1x 236 78 similar similar JJ cord-016652-x8t3lf1x 236 79 to to IN cord-016652-x8t3lf1x 236 80 the the DT cord-016652-x8t3lf1x 236 81 herpes herpes NNP cord-016652-x8t3lf1x 236 82 simplex simplex NNP cord-016652-x8t3lf1x 236 83 virus virus NN cord-016652-x8t3lf1x 236 84 - - HYPH cord-016652-x8t3lf1x 236 85 encoded encode VBN cord-016652-x8t3lf1x 236 86 virulence virulence NN cord-016652-x8t3lf1x 236 87 factor factor NN cord-016652-x8t3lf1x 237 1 ICP34.5 ICP34.5 NNP cord-016652-x8t3lf1x 238 1 The the DT cord-016652-x8t3lf1x 238 2 nucleoprotein nucleoprotein NN cord-016652-x8t3lf1x 238 3 and and CC cord-016652-x8t3lf1x 238 4 the the DT cord-016652-x8t3lf1x 238 5 viral viral JJ cord-016652-x8t3lf1x 238 6 RNA RNA NNP cord-016652-x8t3lf1x 238 7 of of IN cord-016652-x8t3lf1x 238 8 infectious infectious JJ cord-016652-x8t3lf1x 238 9 salmon salmon NN cord-016652-x8t3lf1x 238 10 anemia anemia NN cord-016652-x8t3lf1x 238 11 virus virus NN cord-016652-x8t3lf1x 238 12 ( ( -LRB- cord-016652-x8t3lf1x 238 13 ISAV ISAV NNP cord-016652-x8t3lf1x 238 14 ) ) -RRB- cord-016652-x8t3lf1x 238 15 are be VBP cord-016652-x8t3lf1x 238 16 localized localize VBN cord-016652-x8t3lf1x 238 17 in in IN cord-016652-x8t3lf1x 238 18 the the DT cord-016652-x8t3lf1x 238 19 nucleolus nucleolus NN cord-016652-x8t3lf1x 238 20 of of IN cord-016652-x8t3lf1x 238 21 infected infected JJ cord-016652-x8t3lf1x 238 22 cells cell NNS cord-016652-x8t3lf1x 239 1 The the DT cord-016652-x8t3lf1x 239 2 bovine bovine JJ cord-016652-x8t3lf1x 239 3 immunodeficiency immunodeficiency NN cord-016652-x8t3lf1x 239 4 virus virus NN cord-016652-x8t3lf1x 239 5 rev rev NNP cord-016652-x8t3lf1x 239 6 protein protein NN cord-016652-x8t3lf1x 239 7 : : : cord-016652-x8t3lf1x 239 8 identification identification NN cord-016652-x8t3lf1x 239 9 of of IN cord-016652-x8t3lf1x 239 10 a a DT cord-016652-x8t3lf1x 239 11 novel novel JJ cord-016652-x8t3lf1x 239 12 lentiviral lentiviral JJ cord-016652-x8t3lf1x 239 13 bipartite bipartite JJ cord-016652-x8t3lf1x 239 14 nuclear nuclear JJ cord-016652-x8t3lf1x 239 15 localization localization NN cord-016652-x8t3lf1x 239 16 signal signal NN cord-016652-x8t3lf1x 239 17 harboring harbor VBG cord-016652-x8t3lf1x 239 18 an an DT cord-016652-x8t3lf1x 239 19 atypical atypical JJ cord-016652-x8t3lf1x 239 20 spacer spacer NN cord-016652-x8t3lf1x 239 21 sequence sequence NN cord-016652-x8t3lf1x 239 22 Cucumber Cucumber NNP cord-016652-x8t3lf1x 239 23 mosaic mosaic JJ cord-016652-x8t3lf1x 239 24 virus virus NN cord-016652-x8t3lf1x 239 25 2b 2b CD cord-016652-x8t3lf1x 239 26 protein protein NN cord-016652-x8t3lf1x 239 27 subcellular subcellular JJ cord-016652-x8t3lf1x 239 28 targets target NNS cord-016652-x8t3lf1x 239 29 and and CC cord-016652-x8t3lf1x 239 30 interactions interaction NNS cord-016652-x8t3lf1x 239 31 : : : cord-016652-x8t3lf1x 240 1 their -PRON- PRP$ cord-016652-x8t3lf1x 240 2 significance significance NN cord-016652-x8t3lf1x 240 3 to to IN cord-016652-x8t3lf1x 240 4 RNA rna NN cord-016652-x8t3lf1x 240 5 silencing silence VBG cord-016652-x8t3lf1x 240 6 suppressor suppressor NN cord-016652-x8t3lf1x 240 7 activity activity NN cord-016652-x8t3lf1x 240 8 Involvement Involvement NNP cord-016652-x8t3lf1x 240 9 of of IN cord-016652-x8t3lf1x 240 10 the the DT cord-016652-x8t3lf1x 240 11 nucleolus nucleolus NN cord-016652-x8t3lf1x 240 12 in in IN cord-016652-x8t3lf1x 240 13 replication replication NN cord-016652-x8t3lf1x 240 14 of of IN cord-016652-x8t3lf1x 240 15 human human JJ cord-016652-x8t3lf1x 240 16 viruses virus NNS cord-016652-x8t3lf1x 240 17 Identification Identification NNP cord-016652-x8t3lf1x 240 18 of of IN cord-016652-x8t3lf1x 240 19 nucleolus nucleolus NN cord-016652-x8t3lf1x 240 20 localization localization NN cord-016652-x8t3lf1x 240 21 signal signal NN cord-016652-x8t3lf1x 240 22 of of IN cord-016652-x8t3lf1x 240 23 betanodavirus betanodavirus NNP cord-016652-x8t3lf1x 240 24 GGNNV GGNNV NNP cord-016652-x8t3lf1x 240 25 protein protein NN cord-016652-x8t3lf1x 240 26 alpha alpha NN cord-016652-x8t3lf1x 240 27 Characterization characterization NN cord-016652-x8t3lf1x 240 28 of of IN cord-016652-x8t3lf1x 240 29 the the DT cord-016652-x8t3lf1x 240 30 nuclear nuclear JJ cord-016652-x8t3lf1x 240 31 and and CC cord-016652-x8t3lf1x 240 32 nucleolar nucleolar JJ cord-016652-x8t3lf1x 240 33 localization localization NN cord-016652-x8t3lf1x 240 34 signals signal NNS cord-016652-x8t3lf1x 240 35 of of IN cord-016652-x8t3lf1x 240 36 bovine bovine JJ cord-016652-x8t3lf1x 240 37 herpesvirus-1 herpesvirus-1 NNP cord-016652-x8t3lf1x 240 38 infected infect VBN cord-016652-x8t3lf1x 240 39 cell cell NN cord-016652-x8t3lf1x 240 40 protein protein NN cord-016652-x8t3lf1x 240 41 27 27 CD cord-016652-x8t3lf1x 240 42 New new JJ cord-016652-x8t3lf1x 240 43 regulatory regulatory JJ cord-016652-x8t3lf1x 240 44 mechanisms mechanism NNS cord-016652-x8t3lf1x 240 45 for for IN cord-016652-x8t3lf1x 240 46 the the DT cord-016652-x8t3lf1x 240 47 intracellular intracellular JJ cord-016652-x8t3lf1x 240 48 localization localization NN cord-016652-x8t3lf1x 240 49 and and CC cord-016652-x8t3lf1x 240 50 trafficking trafficking NN cord-016652-x8t3lf1x 240 51 of of IN cord-016652-x8t3lf1x 240 52 influenza influenza NN cord-016652-x8t3lf1x 240 53 A a DT cord-016652-x8t3lf1x 240 54 virus virus NN cord-016652-x8t3lf1x 240 55 NS1 ns1 NN cord-016652-x8t3lf1x 240 56 protein protein NN cord-016652-x8t3lf1x 240 57 revealed reveal VBN cord-016652-x8t3lf1x 240 58 by by IN cord-016652-x8t3lf1x 240 59 comparative comparative JJ cord-016652-x8t3lf1x 240 60 analysis analysis NN cord-016652-x8t3lf1x 240 61 of of IN cord-016652-x8t3lf1x 240 62 A A NNP cord-016652-x8t3lf1x 240 63 / / SYM cord-016652-x8t3lf1x 240 64 PR/8/34 PR/8/34 NNP cord-016652-x8t3lf1x 240 65 and and CC cord-016652-x8t3lf1x 240 66 A A NNP cord-016652-x8t3lf1x 240 67 / / SYM cord-016652-x8t3lf1x 240 68 Sydney/5/97 Sydney/5/97 NNP cord-016652-x8t3lf1x 240 69 Imaging Imaging NNP cord-016652-x8t3lf1x 240 70 of of IN cord-016652-x8t3lf1x 240 71 viroids viroid NNS cord-016652-x8t3lf1x 240 72 in in IN cord-016652-x8t3lf1x 240 73 nuclei nucleus NNS cord-016652-x8t3lf1x 240 74 from from IN cord-016652-x8t3lf1x 240 75 tomato tomato NN cord-016652-x8t3lf1x 240 76 leaf leaf NN cord-016652-x8t3lf1x 240 77 tissue tissue NN cord-016652-x8t3lf1x 240 78 by by IN cord-016652-x8t3lf1x 240 79 in in IN cord-016652-x8t3lf1x 240 80 situ situ NN cord-016652-x8t3lf1x 240 81 hybridization hybridization NN cord-016652-x8t3lf1x 240 82 and and CC cord-016652-x8t3lf1x 240 83 confocal confocal JJ cord-016652-x8t3lf1x 240 84 laser laser NN cord-016652-x8t3lf1x 240 85 scanning scanning NN cord-016652-x8t3lf1x 240 86 microscopy microscopy NN cord-016652-x8t3lf1x 240 87 Distinctions distinction NNS cord-016652-x8t3lf1x 240 88 between between IN cord-016652-x8t3lf1x 240 89 bovine bovine JJ cord-016652-x8t3lf1x 240 90 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 240 91 1 1 CD cord-016652-x8t3lf1x 240 92 and and CC cord-016652-x8t3lf1x 240 93 herpes herpes NNP cord-016652-x8t3lf1x 240 94 simplex simplex NNP cord-016652-x8t3lf1x 240 95 virus virus NN cord-016652-x8t3lf1x 240 96 type type NN cord-016652-x8t3lf1x 240 97 1 1 CD cord-016652-x8t3lf1x 240 98 VP22 VP22 NNP cord-016652-x8t3lf1x 240 99 tegument tegument NN cord-016652-x8t3lf1x 240 100 protein protein NN cord-016652-x8t3lf1x 240 101 subcellular subcellular JJ cord-016652-x8t3lf1x 240 102 associations association NNS cord-016652-x8t3lf1x 240 103 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 240 104 localization localization NN cord-016652-x8t3lf1x 240 105 of of IN cord-016652-x8t3lf1x 240 106 potato potato NNP cord-016652-x8t3lf1x 240 107 leafroll leafroll NNP cord-016652-x8t3lf1x 240 108 virus virus NN cord-016652-x8t3lf1x 240 109 capsid capsid NN cord-016652-x8t3lf1x 240 110 proteins protein VBZ cord-016652-x8t3lf1x 240 111 Relationship relationship NN cord-016652-x8t3lf1x 240 112 between between IN cord-016652-x8t3lf1x 240 113 adenovirus adenovirus NN cord-016652-x8t3lf1x 240 114 DNA dna NN cord-016652-x8t3lf1x 240 115 replication replication NN cord-016652-x8t3lf1x 240 116 proteins protein NNS cord-016652-x8t3lf1x 240 117 and and CC cord-016652-x8t3lf1x 240 118 nucleolar nucleolar JJ cord-016652-x8t3lf1x 240 119 proteins protein NNS cord-016652-x8t3lf1x 240 120 B23.1 b23.1 VBP cord-016652-x8t3lf1x 240 121 and and CC cord-016652-x8t3lf1x 240 122 B23.2 B23.2 NNP cord-016652-x8t3lf1x 240 123 Direct direct JJ cord-016652-x8t3lf1x 240 124 interaction interaction NN cord-016652-x8t3lf1x 240 125 between between IN cord-016652-x8t3lf1x 240 126 nucleolin nucleolin NNP cord-016652-x8t3lf1x 240 127 and and CC cord-016652-x8t3lf1x 240 128 hepatitis hepatitis NN cord-016652-x8t3lf1x 240 129 C C NNP cord-016652-x8t3lf1x 240 130 virus virus NN cord-016652-x8t3lf1x 241 1 NS5B NS5B NNP cord-016652-x8t3lf1x 241 2 Brief Brief NNP cord-016652-x8t3lf1x 241 3 review review NN cord-016652-x8t3lf1x 241 4 : : : cord-016652-x8t3lf1x 242 1 the the DT cord-016652-x8t3lf1x 242 2 nucleolus nucleolus NN cord-016652-x8t3lf1x 242 3 -a -a HYPH cord-016652-x8t3lf1x 242 4 gateway gateway NN cord-016652-x8t3lf1x 242 5 to to IN cord-016652-x8t3lf1x 242 6 viral viral JJ cord-016652-x8t3lf1x 242 7 infection infection NN cord-016652-x8t3lf1x 242 8 ? ? . cord-016652-x8t3lf1x 243 1 The the DT cord-016652-x8t3lf1x 243 2 interaction interaction NN cord-016652-x8t3lf1x 243 3 of of IN cord-016652-x8t3lf1x 243 4 animal animal NN cord-016652-x8t3lf1x 243 5 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 243 6 RNA RNA NNP cord-016652-x8t3lf1x 243 7 viruses virus NNS cord-016652-x8t3lf1x 243 8 with with IN cord-016652-x8t3lf1x 243 9 the the DT cord-016652-x8t3lf1x 243 10 nucleus nucleus NN cord-016652-x8t3lf1x 243 11 to to TO cord-016652-x8t3lf1x 243 12 facilitate facilitate VB cord-016652-x8t3lf1x 243 13 replication replication NN cord-016652-x8t3lf1x 243 14 RNA rna NN cord-016652-x8t3lf1x 243 15 viruses virus NNS cord-016652-x8t3lf1x 243 16 : : : cord-016652-x8t3lf1x 243 17 hijacking hijack VBG cord-016652-x8t3lf1x 243 18 the the DT cord-016652-x8t3lf1x 243 19 dynamic dynamic JJ cord-016652-x8t3lf1x 243 20 nucleolus nucleolus NN cord-016652-x8t3lf1x 243 21 The the DT cord-016652-x8t3lf1x 243 22 coronavirus coronavirus NN cord-016652-x8t3lf1x 243 23 infectious infectious JJ cord-016652-x8t3lf1x 243 24 bronchitis bronchitis NN cord-016652-x8t3lf1x 243 25 virus virus NN cord-016652-x8t3lf1x 243 26 nucleoprotein nucleoprotein NNP cord-016652-x8t3lf1x 243 27 localizes localize VBZ cord-016652-x8t3lf1x 243 28 to to IN cord-016652-x8t3lf1x 243 29 the the DT cord-016652-x8t3lf1x 243 30 nucleolus nucleolus NN cord-016652-x8t3lf1x 243 31 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 243 32 proteomics proteomic NNS cord-016652-x8t3lf1x 243 33 and and CC cord-016652-x8t3lf1x 243 34 viral viral JJ cord-016652-x8t3lf1x 243 35 infection infection NN cord-016652-x8t3lf1x 244 1 The the DT cord-016652-x8t3lf1x 244 2 HBZ HBZ NNP cord-016652-x8t3lf1x 244 3 - - HYPH cord-016652-x8t3lf1x 244 4 SP1 SP1 NNP cord-016652-x8t3lf1x 244 5 isoform isoform NN cord-016652-x8t3lf1x 244 6 of of IN cord-016652-x8t3lf1x 244 7 human human JJ cord-016652-x8t3lf1x 244 8 T t NN cord-016652-x8t3lf1x 244 9 - - HYPH cord-016652-x8t3lf1x 244 10 cell cell NN cord-016652-x8t3lf1x 244 11 leukemia leukemia NN cord-016652-x8t3lf1x 244 12 virus virus NN cord-016652-x8t3lf1x 244 13 type type NN cord-016652-x8t3lf1x 244 14 I -PRON- PRP cord-016652-x8t3lf1x 244 15 represses repress VBZ cord-016652-x8t3lf1x 244 16 JunB JunB NNP cord-016652-x8t3lf1x 244 17 activity activity NN cord-016652-x8t3lf1x 244 18 by by IN cord-016652-x8t3lf1x 244 19 sequestration sequestration NN cord-016652-x8t3lf1x 244 20 into into IN cord-016652-x8t3lf1x 244 21 nuclear nuclear JJ cord-016652-x8t3lf1x 244 22 bodies body NNS cord-016652-x8t3lf1x 244 23 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 244 24 localization localization NN cord-016652-x8t3lf1x 244 25 of of IN cord-016652-x8t3lf1x 244 26 mouse mouse NN cord-016652-x8t3lf1x 244 27 mammary mammary JJ cord-016652-x8t3lf1x 244 28 tumor tumor NN cord-016652-x8t3lf1x 244 29 virus virus NN cord-016652-x8t3lf1x 244 30 proteins protein NNS cord-016652-x8t3lf1x 244 31 in in IN cord-016652-x8t3lf1x 244 32 T t NN cord-016652-x8t3lf1x 244 33 - - HYPH cord-016652-x8t3lf1x 244 34 cell cell NN cord-016652-x8t3lf1x 244 35 lymphomas lymphoma NNS cord-016652-x8t3lf1x 244 36 Identification identification NN cord-016652-x8t3lf1x 244 37 and and CC cord-016652-x8t3lf1x 244 38 characterization characterization NN cord-016652-x8t3lf1x 244 39 of of IN cord-016652-x8t3lf1x 244 40 the the DT cord-016652-x8t3lf1x 244 41 UL24 UL24 NNP cord-016652-x8t3lf1x 244 42 gene gene NN cord-016652-x8t3lf1x 244 43 product product NN cord-016652-x8t3lf1x 244 44 of of IN cord-016652-x8t3lf1x 244 45 herpes herpes NNP cord-016652-x8t3lf1x 244 46 simplex simplex NNP cord-016652-x8t3lf1x 244 47 virus virus NN cord-016652-x8t3lf1x 244 48 type type NN cord-016652-x8t3lf1x 244 49 2 2 CD cord-016652-x8t3lf1x 245 1 The the DT cord-016652-x8t3lf1x 245 2 nucleolar nucleolar JJ cord-016652-x8t3lf1x 245 3 phosphoprotein phosphoprotein NN cord-016652-x8t3lf1x 245 4 B23 B23 NNP cord-016652-x8t3lf1x 245 5 interacts interact VBZ cord-016652-x8t3lf1x 245 6 with with IN cord-016652-x8t3lf1x 245 7 hepatitis hepatitis NN cord-016652-x8t3lf1x 245 8 delta delta NNP cord-016652-x8t3lf1x 245 9 antigens antigen NNS cord-016652-x8t3lf1x 245 10 and and CC cord-016652-x8t3lf1x 245 11 modulates modulate VBZ cord-016652-x8t3lf1x 245 12 the the DT cord-016652-x8t3lf1x 245 13 hepatitis hepatitis NN cord-016652-x8t3lf1x 245 14 delta delta NNP cord-016652-x8t3lf1x 245 15 virus virus NN cord-016652-x8t3lf1x 245 16 RNA RNA NNP cord-016652-x8t3lf1x 245 17 replication replication NN cord-016652-x8t3lf1x 245 18 Expression expression NN cord-016652-x8t3lf1x 245 19 and and CC cord-016652-x8t3lf1x 245 20 processing processing NN cord-016652-x8t3lf1x 245 21 of of IN cord-016652-x8t3lf1x 245 22 a a DT cord-016652-x8t3lf1x 245 23 small small JJ cord-016652-x8t3lf1x 245 24 nucleolar nucleolar NNS cord-016652-x8t3lf1x 245 25 RNA RNA NNP cord-016652-x8t3lf1x 245 26 from from IN cord-016652-x8t3lf1x 245 27 the the DT cord-016652-x8t3lf1x 245 28 Epstein Epstein NNP cord-016652-x8t3lf1x 245 29 - - HYPH cord-016652-x8t3lf1x 245 30 Barr Barr NNP cord-016652-x8t3lf1x 245 31 virus virus NN cord-016652-x8t3lf1x 245 32 genome genome NN cord-016652-x8t3lf1x 245 33 A a DT cord-016652-x8t3lf1x 245 34 novel novel NN cord-016652-x8t3lf1x 245 35 , , , cord-016652-x8t3lf1x 245 36 mouse mouse NN cord-016652-x8t3lf1x 245 37 mammary mammary JJ cord-016652-x8t3lf1x 245 38 tumor tumor NN cord-016652-x8t3lf1x 245 39 virus virus NN cord-016652-x8t3lf1x 245 40 encoded encode VBD cord-016652-x8t3lf1x 245 41 protein protein NN cord-016652-x8t3lf1x 245 42 with with IN cord-016652-x8t3lf1x 245 43 Rev Rev NNP cord-016652-x8t3lf1x 245 44 - - HYPH cord-016652-x8t3lf1x 245 45 like like JJ cord-016652-x8t3lf1x 245 46 properties property NNS cord-016652-x8t3lf1x 245 47 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 245 48 accumulation accumulation NN cord-016652-x8t3lf1x 245 49 of of IN cord-016652-x8t3lf1x 245 50 Semliki Semliki NNP cord-016652-x8t3lf1x 245 51 Forest Forest NNP cord-016652-x8t3lf1x 245 52 virus virus NN cord-016652-x8t3lf1x 245 53 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 245 54 C C NNP cord-016652-x8t3lf1x 245 55 protein protein NN cord-016652-x8t3lf1x 245 56 : : : cord-016652-x8t3lf1x 245 57 influence influence NN cord-016652-x8t3lf1x 245 58 of of IN cord-016652-x8t3lf1x 245 59 metabolic metabolic JJ cord-016652-x8t3lf1x 245 60 status status NN cord-016652-x8t3lf1x 245 61 , , , cord-016652-x8t3lf1x 245 62 cytoskeleton cytoskeleton NN cord-016652-x8t3lf1x 245 63 and and CC cord-016652-x8t3lf1x 245 64 receptors receptor NNS cord-016652-x8t3lf1x 245 65 GLTSCR2 GLTSCR2 NNS cord-016652-x8t3lf1x 245 66 / / SYM cord-016652-x8t3lf1x 245 67 PICT-1 PICT-1 VBD cord-016652-x8t3lf1x 245 68 , , , cord-016652-x8t3lf1x 245 69 a a DT cord-016652-x8t3lf1x 245 70 putative putative JJ cord-016652-x8t3lf1x 245 71 tumor tumor NN cord-016652-x8t3lf1x 245 72 suppressor suppressor NN cord-016652-x8t3lf1x 245 73 gene gene NN cord-016652-x8t3lf1x 245 74 product product NN cord-016652-x8t3lf1x 245 75 , , , cord-016652-x8t3lf1x 245 76 induces induce VBZ cord-016652-x8t3lf1x 245 77 the the DT cord-016652-x8t3lf1x 245 78 nucleolar nucleolar JJ cord-016652-x8t3lf1x 245 79 targeting target VBG cord-016652-x8t3lf1x 245 80 of of IN cord-016652-x8t3lf1x 245 81 the the DT cord-016652-x8t3lf1x 245 82 Kaposi Kaposi NNP cord-016652-x8t3lf1x 245 83 's 's POS cord-016652-x8t3lf1x 245 84 sarcoma sarcoma NN cord-016652-x8t3lf1x 245 85 - - HYPH cord-016652-x8t3lf1x 245 86 associated associate VBN cord-016652-x8t3lf1x 245 87 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 245 88 KS KS NNP cord-016652-x8t3lf1x 245 89 - - HYPH cord-016652-x8t3lf1x 245 90 Bcl-2 Bcl-2 NNP cord-016652-x8t3lf1x 245 91 protein protein NN cord-016652-x8t3lf1x 245 92 Interaction Interaction NNP cord-016652-x8t3lf1x 245 93 of of IN cord-016652-x8t3lf1x 245 94 a a DT cord-016652-x8t3lf1x 245 95 plant plant NN cord-016652-x8t3lf1x 245 96 virus virus NN cord-016652-x8t3lf1x 245 97 - - HYPH cord-016652-x8t3lf1x 245 98 encoded encode VBN cord-016652-x8t3lf1x 245 99 protein protein NN cord-016652-x8t3lf1x 245 100 with with IN cord-016652-x8t3lf1x 245 101 the the DT cord-016652-x8t3lf1x 245 102 major major JJ cord-016652-x8t3lf1x 245 103 nucleolar nucleolar JJ cord-016652-x8t3lf1x 245 104 protein protein NN cord-016652-x8t3lf1x 245 105 fibrillarin fibrillarin NNP cord-016652-x8t3lf1x 245 106 is be VBZ cord-016652-x8t3lf1x 245 107 required require VBN cord-016652-x8t3lf1x 245 108 for for IN cord-016652-x8t3lf1x 245 109 systemic systemic JJ cord-016652-x8t3lf1x 245 110 virus virus NN cord-016652-x8t3lf1x 245 111 infection infection NN cord-016652-x8t3lf1x 245 112 Cajal Cajal NNP cord-016652-x8t3lf1x 245 113 bodies body NNS cord-016652-x8t3lf1x 245 114 and and CC cord-016652-x8t3lf1x 245 115 the the DT cord-016652-x8t3lf1x 245 116 nucleolus nucleolus NN cord-016652-x8t3lf1x 245 117 are be VBP cord-016652-x8t3lf1x 245 118 required require VBN cord-016652-x8t3lf1x 245 119 for for IN cord-016652-x8t3lf1x 245 120 a a DT cord-016652-x8t3lf1x 245 121 plant plant NN cord-016652-x8t3lf1x 245 122 virus virus NN cord-016652-x8t3lf1x 245 123 systemic systemic JJ cord-016652-x8t3lf1x 245 124 infection infection NN cord-016652-x8t3lf1x 245 125 Electron electron NN cord-016652-x8t3lf1x 245 126 microscopy microscopy NN cord-016652-x8t3lf1x 245 127 of of IN cord-016652-x8t3lf1x 245 128 ribonucleic ribonucleic JJ cord-016652-x8t3lf1x 245 129 acid acid NN cord-016652-x8t3lf1x 245 130 in in IN cord-016652-x8t3lf1x 245 131 nuclear nuclear JJ cord-016652-x8t3lf1x 245 132 particulate particulate NN cord-016652-x8t3lf1x 245 133 aggregates aggregate NNS cord-016652-x8t3lf1x 245 134 of of IN cord-016652-x8t3lf1x 245 135 hepatitis hepatitis NN cord-016652-x8t3lf1x 245 136 D D NNP cord-016652-x8t3lf1x 245 137 using use VBG cord-016652-x8t3lf1x 245 138 nuclease nuclease NN cord-016652-x8t3lf1x 245 139 - - HYPH cord-016652-x8t3lf1x 245 140 gold gold NN cord-016652-x8t3lf1x 245 141 complexes complex NNS cord-016652-x8t3lf1x 246 1 Functional functional JJ cord-016652-x8t3lf1x 246 2 similarity similarity NN cord-016652-x8t3lf1x 246 3 of of IN cord-016652-x8t3lf1x 246 4 HIV HIV NNP cord-016652-x8t3lf1x 246 5 - - : cord-016652-x8t3lf1x 246 6 I -PRON- PRP cord-016652-x8t3lf1x 246 7 rev rev VBP cord-016652-x8t3lf1x 246 8 and and CC cord-016652-x8t3lf1x 246 9 HTLV HTLV NNP cord-016652-x8t3lf1x 246 10 - - HYPH cord-016652-x8t3lf1x 246 11 I I NNP cord-016652-x8t3lf1x 246 12 rex rex NNP cord-016652-x8t3lf1x 246 13 proteins protein NNS cord-016652-x8t3lf1x 246 14 : : : cord-016652-x8t3lf1x 246 15 identification identification NN cord-016652-x8t3lf1x 246 16 of of IN cord-016652-x8t3lf1x 246 17 a a DT cord-016652-x8t3lf1x 246 18 new new JJ cord-016652-x8t3lf1x 246 19 nucleolar nucleolar NN cord-016652-x8t3lf1x 246 20 - - HYPH cord-016652-x8t3lf1x 246 21 targeting target VBG cord-016652-x8t3lf1x 246 22 signal signal NN cord-016652-x8t3lf1x 246 23 in in IN cord-016652-x8t3lf1x 246 24 rev rev NNP cord-016652-x8t3lf1x 246 25 protein protein NN cord-016652-x8t3lf1x 246 26 Nucleo nucleo JJ cord-016652-x8t3lf1x 246 27 - - HYPH cord-016652-x8t3lf1x 246 28 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 246 29 redistribution redistribution NN cord-016652-x8t3lf1x 246 30 of of IN cord-016652-x8t3lf1x 246 31 the the DT cord-016652-x8t3lf1x 246 32 HTLV HTLV NNP cord-016652-x8t3lf1x 246 33 - - HYPH cord-016652-x8t3lf1x 246 34 I I NNP cord-016652-x8t3lf1x 246 35 Rex Rex NNP cord-016652-x8t3lf1x 246 36 protein protein NN cord-016652-x8t3lf1x 246 37 : : : cord-016652-x8t3lf1x 246 38 alterations alteration NNS cord-016652-x8t3lf1x 246 39 by by IN cord-016652-x8t3lf1x 246 40 coexpression coexpression NN cord-016652-x8t3lf1x 246 41 of of IN cord-016652-x8t3lf1x 246 42 the the DT cord-016652-x8t3lf1x 246 43 HTLV- HTLV- NNS cord-016652-x8t3lf1x 247 1 I -PRON- PRP cord-016652-x8t3lf1x 248 1 p21x p21x . cord-016652-x8t3lf1x 249 1 protein protein NNP cord-016652-x8t3lf1x 249 2 Proteomics Proteomics NNP cord-016652-x8t3lf1x 249 3 analysis analysis NN cord-016652-x8t3lf1x 249 4 of of IN cord-016652-x8t3lf1x 249 5 the the DT cord-016652-x8t3lf1x 249 6 nucleolus nucleolus NN cord-016652-x8t3lf1x 249 7 in in IN cord-016652-x8t3lf1x 249 8 adenovirus adenovirus NN cord-016652-x8t3lf1x 249 9 - - HYPH cord-016652-x8t3lf1x 249 10 infected infect VBN cord-016652-x8t3lf1x 249 11 cells cell NNS cord-016652-x8t3lf1x 250 1 Immunocytology immunocytology NN cord-016652-x8t3lf1x 250 2 shows show VBZ cord-016652-x8t3lf1x 250 3 the the DT cord-016652-x8t3lf1x 250 4 presence presence NN cord-016652-x8t3lf1x 250 5 of of IN cord-016652-x8t3lf1x 250 6 tobacco tobacco NN cord-016652-x8t3lf1x 250 7 etch etch NN cord-016652-x8t3lf1x 250 8 virus virus NN cord-016652-x8t3lf1x 250 9 P3 P3 NNP cord-016652-x8t3lf1x 250 10 protein protein NN cord-016652-x8t3lf1x 250 11 in in IN cord-016652-x8t3lf1x 250 12 nuclear nuclear JJ cord-016652-x8t3lf1x 250 13 inclusions inclusion NNS cord-016652-x8t3lf1x 250 14 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 250 15 protein protein NN cord-016652-x8t3lf1x 250 16 upstream upstream RB cord-016652-x8t3lf1x 250 17 binding binding NN cord-016652-x8t3lf1x 250 18 factor factor NN cord-016652-x8t3lf1x 250 19 is be VBZ cord-016652-x8t3lf1x 250 20 sequestered sequester VBN cord-016652-x8t3lf1x 250 21 into into IN cord-016652-x8t3lf1x 250 22 adenovirus adenovirus NN cord-016652-x8t3lf1x 250 23 DNA dna NN cord-016652-x8t3lf1x 250 24 replication replication NN cord-016652-x8t3lf1x 250 25 centres centre NNS cord-016652-x8t3lf1x 250 26 during during IN cord-016652-x8t3lf1x 250 27 infection infection NN cord-016652-x8t3lf1x 250 28 without without IN cord-016652-x8t3lf1x 250 29 affecting affect VBG cord-016652-x8t3lf1x 250 30 RNA rna NN cord-016652-x8t3lf1x 250 31 polymerase polymerase NN cord-016652-x8t3lf1x 250 32 I -PRON- PRP cord-016652-x8t3lf1x 250 33 location location NN cord-016652-x8t3lf1x 250 34 or or CC cord-016652-x8t3lf1x 250 35 ablating ablate VBG cord-016652-x8t3lf1x 250 36 rRNA rRNA NNP cord-016652-x8t3lf1x 250 37 synthesis synthesis NN cord-016652-x8t3lf1x 250 38 A a DT cord-016652-x8t3lf1x 250 39 B23-interacting B23-interacting NNP cord-016652-x8t3lf1x 250 40 sequence sequence NN cord-016652-x8t3lf1x 250 41 as as IN cord-016652-x8t3lf1x 250 42 a a DT cord-016652-x8t3lf1x 250 43 tool tool NN cord-016652-x8t3lf1x 250 44 to to TO cord-016652-x8t3lf1x 250 45 visualize visualize VB cord-016652-x8t3lf1x 250 46 protein protein NN cord-016652-x8t3lf1x 250 47 interactions interaction NNS cord-016652-x8t3lf1x 250 48 in in IN cord-016652-x8t3lf1x 250 49 a a DT cord-016652-x8t3lf1x 250 50 cellular cellular JJ cord-016652-x8t3lf1x 250 51 context context NN cord-016652-x8t3lf1x 251 1 The the DT cord-016652-x8t3lf1x 251 2 nucleolin nucleolin NN cord-016652-x8t3lf1x 251 3 binding bind VBG cord-016652-x8t3lf1x 251 4 activity activity NN cord-016652-x8t3lf1x 251 5 of of IN cord-016652-x8t3lf1x 251 6 hepatitis hepatitis NN cord-016652-x8t3lf1x 251 7 delta delta NNP cord-016652-x8t3lf1x 251 8 antigen antigen NNP cord-016652-x8t3lf1x 251 9 is be VBZ cord-016652-x8t3lf1x 251 10 associated associate VBN cord-016652-x8t3lf1x 251 11 with with IN cord-016652-x8t3lf1x 251 12 nucleolus nucleolus NN cord-016652-x8t3lf1x 251 13 targeting target VBG cord-016652-x8t3lf1x 252 1 Adenovirus Adenovirus NNP cord-016652-x8t3lf1x 252 2 core core NN cord-016652-x8t3lf1x 252 3 protein protein NN cord-016652-x8t3lf1x 252 4 VII VII NNP cord-016652-x8t3lf1x 252 5 contains contain VBZ cord-016652-x8t3lf1x 252 6 distinct distinct JJ cord-016652-x8t3lf1x 252 7 sequences sequence NNS cord-016652-x8t3lf1x 252 8 that that WDT cord-016652-x8t3lf1x 252 9 mediate mediate VBP cord-016652-x8t3lf1x 252 10 targeting target VBG cord-016652-x8t3lf1x 252 11 to to IN cord-016652-x8t3lf1x 252 12 the the DT cord-016652-x8t3lf1x 252 13 nucleus nucleus NN cord-016652-x8t3lf1x 252 14 and and CC cord-016652-x8t3lf1x 252 15 nucleolus nucleolus NN cord-016652-x8t3lf1x 252 16 , , , cord-016652-x8t3lf1x 252 17 and and CC cord-016652-x8t3lf1x 252 18 colocalization colocalization NN cord-016652-x8t3lf1x 252 19 with with IN cord-016652-x8t3lf1x 252 20 human human JJ cord-016652-x8t3lf1x 252 21 chromosomes chromosome NNS cord-016652-x8t3lf1x 252 22 Precursor Precursor NNP cord-016652-x8t3lf1x 252 23 of of IN cord-016652-x8t3lf1x 252 24 human human JJ cord-016652-x8t3lf1x 252 25 adenovirus adenovirus NN cord-016652-x8t3lf1x 252 26 core core NN cord-016652-x8t3lf1x 252 27 polypeptide polypeptide NN cord-016652-x8t3lf1x 252 28 Mu Mu NNP cord-016652-x8t3lf1x 252 29 targets target VBZ cord-016652-x8t3lf1x 252 30 the the DT cord-016652-x8t3lf1x 252 31 nucleolus nucleolus NN cord-016652-x8t3lf1x 252 32 and and CC cord-016652-x8t3lf1x 252 33 modulates modulate VBZ cord-016652-x8t3lf1x 252 34 the the DT cord-016652-x8t3lf1x 252 35 expression expression NN cord-016652-x8t3lf1x 252 36 of of IN cord-016652-x8t3lf1x 252 37 E2 E2 NNP cord-016652-x8t3lf1x 252 38 proteins protein NNS cord-016652-x8t3lf1x 252 39 Mutations Mutations NNPS cord-016652-x8t3lf1x 252 40 within within IN cord-016652-x8t3lf1x 252 41 the the DT cord-016652-x8t3lf1x 252 42 nuclear nuclear JJ cord-016652-x8t3lf1x 252 43 localization localization NN cord-016652-x8t3lf1x 252 44 signal signal NN cord-016652-x8t3lf1x 252 45 of of IN cord-016652-x8t3lf1x 252 46 the the DT cord-016652-x8t3lf1x 252 47 porcine porcine JJ cord-016652-x8t3lf1x 252 48 reproductive reproductive JJ cord-016652-x8t3lf1x 252 49 and and CC cord-016652-x8t3lf1x 252 50 respiratory respiratory JJ cord-016652-x8t3lf1x 252 51 syndrome syndrome NN cord-016652-x8t3lf1x 252 52 virus virus NN cord-016652-x8t3lf1x 252 53 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 252 54 protein protein NN cord-016652-x8t3lf1x 252 55 attenuate attenuate VBP cord-016652-x8t3lf1x 252 56 virus virus NN cord-016652-x8t3lf1x 252 57 replication replication NN cord-016652-x8t3lf1x 253 1 The the DT cord-016652-x8t3lf1x 253 2 alcelaphine alcelaphine NN cord-016652-x8t3lf1x 253 3 herpesvirus-1 herpesvirus-1 NNP cord-016652-x8t3lf1x 253 4 ORF ORF NNP cord-016652-x8t3lf1x 253 5 57 57 CD cord-016652-x8t3lf1x 253 6 encodes encode VBZ cord-016652-x8t3lf1x 253 7 a a DT cord-016652-x8t3lf1x 253 8 nuclear nuclear JJ cord-016652-x8t3lf1x 253 9 shuttling shuttle VBG cord-016652-x8t3lf1x 253 10 protein protein JJ cord-016652-x8t3lf1x 253 11 Functional functional JJ cord-016652-x8t3lf1x 253 12 interaction interaction NN cord-016652-x8t3lf1x 253 13 and and CC cord-016652-x8t3lf1x 253 14 colocalization colocalization NN cord-016652-x8t3lf1x 253 15 of of IN cord-016652-x8t3lf1x 253 16 the the DT cord-016652-x8t3lf1x 253 17 herpes herpes NNP cord-016652-x8t3lf1x 253 18 simplex simplex NNP cord-016652-x8t3lf1x 253 19 virus virus NN cord-016652-x8t3lf1x 253 20 1 1 CD cord-016652-x8t3lf1x 253 21 major major JJ cord-016652-x8t3lf1x 253 22 regulatory regulatory JJ cord-016652-x8t3lf1x 253 23 protein protein NN cord-016652-x8t3lf1x 253 24 ICP4 ICP4 NNP cord-016652-x8t3lf1x 253 25 with with IN cord-016652-x8t3lf1x 253 26 EAP EAP NNP cord-016652-x8t3lf1x 253 27 , , , cord-016652-x8t3lf1x 253 28 a a DT cord-016652-x8t3lf1x 253 29 nucleolar nucleolar JJ cord-016652-x8t3lf1x 253 30 - - HYPH cord-016652-x8t3lf1x 253 31 ribosomal ribosomal JJ cord-016652-x8t3lf1x 253 32 protein protein NN cord-016652-x8t3lf1x 253 33 RNA rna NN cord-016652-x8t3lf1x 253 34 - - HYPH cord-016652-x8t3lf1x 253 35 templated templated JJ cord-016652-x8t3lf1x 253 36 replication replication NN cord-016652-x8t3lf1x 253 37 of of IN cord-016652-x8t3lf1x 253 38 hepatitis hepatitis NN cord-016652-x8t3lf1x 253 39 delta delta NNP cord-016652-x8t3lf1x 253 40 virus virus NN cord-016652-x8t3lf1x 253 41 : : : cord-016652-x8t3lf1x 253 42 genomic genomic JJ cord-016652-x8t3lf1x 253 43 and and CC cord-016652-x8t3lf1x 253 44 antigenomic antigenomic NNP cord-016652-x8t3lf1x 253 45 RNAs rna NNS cord-016652-x8t3lf1x 253 46 associate associate VBP cord-016652-x8t3lf1x 253 47 with with IN cord-016652-x8t3lf1x 253 48 different different JJ cord-016652-x8t3lf1x 253 49 nuclear nuclear JJ cord-016652-x8t3lf1x 253 50 bodies body NNS cord-016652-x8t3lf1x 254 1 Capsid capsid JJ cord-016652-x8t3lf1x 254 2 protein protein NN cord-016652-x8t3lf1x 254 3 of of IN cord-016652-x8t3lf1x 254 4 cucumber cucumber NN cord-016652-x8t3lf1x 254 5 mosaic mosaic JJ cord-016652-x8t3lf1x 254 6 virus virus NN cord-016652-x8t3lf1x 254 7 accumulates accumulate VBZ cord-016652-x8t3lf1x 254 8 in in IN cord-016652-x8t3lf1x 254 9 the the DT cord-016652-x8t3lf1x 254 10 nuclei nucleus NNS cord-016652-x8t3lf1x 254 11 and and CC cord-016652-x8t3lf1x 254 12 at at IN cord-016652-x8t3lf1x 254 13 the the DT cord-016652-x8t3lf1x 254 14 periphery periphery NN cord-016652-x8t3lf1x 254 15 of of IN cord-016652-x8t3lf1x 254 16 the the DT cord-016652-x8t3lf1x 254 17 nucleoli nucleoli NNP cord-016652-x8t3lf1x 254 18 in in IN cord-016652-x8t3lf1x 254 19 infected infected JJ cord-016652-x8t3lf1x 254 20 cells cell NNS cord-016652-x8t3lf1x 254 21 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 254 22 and and CC cord-016652-x8t3lf1x 254 23 nuclear nuclear JJ cord-016652-x8t3lf1x 254 24 localization localization NN cord-016652-x8t3lf1x 254 25 properties property NNS cord-016652-x8t3lf1x 254 26 of of IN cord-016652-x8t3lf1x 254 27 a a DT cord-016652-x8t3lf1x 254 28 herpesvirus herpesvirus NN cord-016652-x8t3lf1x 254 29 bZIP bZIP NNP cord-016652-x8t3lf1x 254 30 oncoprotein oncoprotein NNP cord-016652-x8t3lf1x 254 31 , , , cord-016652-x8t3lf1x 255 1 MEQ MEQ NNP cord-016652-x8t3lf1x 256 1 The the DT cord-016652-x8t3lf1x 256 2 major major JJ cord-016652-x8t3lf1x 256 3 tegument tegument NN cord-016652-x8t3lf1x 256 4 structural structural JJ cord-016652-x8t3lf1x 256 5 protein protein NN cord-016652-x8t3lf1x 256 6 VP22 VP22 NNP cord-016652-x8t3lf1x 256 7 targets target VBZ cord-016652-x8t3lf1x 256 8 areas area NNS cord-016652-x8t3lf1x 256 9 of of IN cord-016652-x8t3lf1x 256 10 dispersed disperse VBN cord-016652-x8t3lf1x 256 11 nucleolin nucleolin NN cord-016652-x8t3lf1x 256 12 and and CC cord-016652-x8t3lf1x 256 13 marginalized marginalize VBN cord-016652-x8t3lf1x 256 14 chromatin chromatin NN cord-016652-x8t3lf1x 256 15 during during IN cord-016652-x8t3lf1x 256 16 productive productive JJ cord-016652-x8t3lf1x 256 17 herpes herpes NN cord-016652-x8t3lf1x 256 18 simplex simplex NN cord-016652-x8t3lf1x 256 19 virus virus NN cord-016652-x8t3lf1x 256 20 1 1 CD cord-016652-x8t3lf1x 256 21 infection infection NN cord-016652-x8t3lf1x 256 22 Identification identification NN cord-016652-x8t3lf1x 256 23 of of IN cord-016652-x8t3lf1x 256 24 a a DT cord-016652-x8t3lf1x 256 25 Rev Rev NNP cord-016652-x8t3lf1x 256 26 - - HYPH cord-016652-x8t3lf1x 256 27 related relate VBN cord-016652-x8t3lf1x 256 28 protein protein NN cord-016652-x8t3lf1x 256 29 by by IN cord-016652-x8t3lf1x 256 30 analysis analysis NN cord-016652-x8t3lf1x 256 31 of of IN cord-016652-x8t3lf1x 256 32 spliced splice VBN cord-016652-x8t3lf1x 256 33 transcripts transcript NNS cord-016652-x8t3lf1x 256 34 of of IN cord-016652-x8t3lf1x 256 35 the the DT cord-016652-x8t3lf1x 256 36 human human JJ cord-016652-x8t3lf1x 256 37 endogenous endogenous JJ cord-016652-x8t3lf1x 256 38 retroviruses retrovirus NNS cord-016652-x8t3lf1x 256 39 HTDV/ HTDV/ NNP cord-016652-x8t3lf1x 256 40 HERV HERV NNP cord-016652-x8t3lf1x 256 41 - - HYPH cord-016652-x8t3lf1x 256 42 K K NNP cord-016652-x8t3lf1x 256 43 Properties Properties NNPS cord-016652-x8t3lf1x 256 44 of of IN cord-016652-x8t3lf1x 256 45 the the DT cord-016652-x8t3lf1x 256 46 adenovirus adenovirus NN cord-016652-x8t3lf1x 256 47 IVa2 IVa2 NNS cord-016652-x8t3lf1x 256 48 gene gene NN cord-016652-x8t3lf1x 256 49 product product NN cord-016652-x8t3lf1x 256 50 , , , cord-016652-x8t3lf1x 256 51 an an DT cord-016652-x8t3lf1x 256 52 effector effector NN cord-016652-x8t3lf1x 256 53 of of IN cord-016652-x8t3lf1x 256 54 late late JJ cord-016652-x8t3lf1x 256 55 - - HYPH cord-016652-x8t3lf1x 256 56 phase phase NN cord-016652-x8t3lf1x 256 57 - - HYPH cord-016652-x8t3lf1x 256 58 dependent dependent JJ cord-016652-x8t3lf1x 256 59 activation activation NN cord-016652-x8t3lf1x 256 60 of of IN cord-016652-x8t3lf1x 256 61 the the DT cord-016652-x8t3lf1x 256 62 major major JJ cord-016652-x8t3lf1x 256 63 late late JJ cord-016652-x8t3lf1x 256 64 promoter promoter NN cord-016652-x8t3lf1x 256 65 Involvement Involvement NNP cord-016652-x8t3lf1x 256 66 of of IN cord-016652-x8t3lf1x 256 67 UL24 UL24 NNP cord-016652-x8t3lf1x 256 68 in in IN cord-016652-x8t3lf1x 256 69 herpes herpes NN cord-016652-x8t3lf1x 256 70 - - HYPH cord-016652-x8t3lf1x 256 71 simplex simplex NN cord-016652-x8t3lf1x 256 72 - - HYPH cord-016652-x8t3lf1x 256 73 virus-1-induced virus-1-induced JJ cord-016652-x8t3lf1x 256 74 dispersal dispersal NN cord-016652-x8t3lf1x 256 75 of of IN cord-016652-x8t3lf1x 256 76 nucleolin nucleolin NNP cord-016652-x8t3lf1x 256 77 Relocalization Relocalization NNP cord-016652-x8t3lf1x 256 78 of of IN cord-016652-x8t3lf1x 256 79 upstream upstream JJ cord-016652-x8t3lf1x 256 80 binding binding NN cord-016652-x8t3lf1x 256 81 factor factor NN cord-016652-x8t3lf1x 256 82 to to IN cord-016652-x8t3lf1x 256 83 viral viral JJ cord-016652-x8t3lf1x 256 84 replication replication NN cord-016652-x8t3lf1x 256 85 compartments compartment NNS cord-016652-x8t3lf1x 256 86 is be VBZ cord-016652-x8t3lf1x 256 87 UL24 UL24 NNP cord-016652-x8t3lf1x 256 88 independent independent JJ cord-016652-x8t3lf1x 256 89 and and CC cord-016652-x8t3lf1x 256 90 follows follow VBZ cord-016652-x8t3lf1x 256 91 the the DT cord-016652-x8t3lf1x 256 92 onset onset NN cord-016652-x8t3lf1x 256 93 of of IN cord-016652-x8t3lf1x 256 94 herpes herpes NNP cord-016652-x8t3lf1x 256 95 simplex simplex NNP cord-016652-x8t3lf1x 256 96 virus virus NN cord-016652-x8t3lf1x 256 97 1 1 CD cord-016652-x8t3lf1x 256 98 DNA dna NN cord-016652-x8t3lf1x 256 99 synthesis synthesis NN cord-016652-x8t3lf1x 256 100 Involvement involvement NN cord-016652-x8t3lf1x 256 101 of of IN cord-016652-x8t3lf1x 256 102 the the DT cord-016652-x8t3lf1x 256 103 UL24 UL24 NNP cord-016652-x8t3lf1x 256 104 protein protein NN cord-016652-x8t3lf1x 256 105 in in IN cord-016652-x8t3lf1x 256 106 herpes herpes NNP cord-016652-x8t3lf1x 256 107 simplex simplex NNP cord-016652-x8t3lf1x 256 108 virus virus NN cord-016652-x8t3lf1x 256 109 1-induced 1-induced CD cord-016652-x8t3lf1x 256 110 dispersal dispersal NN cord-016652-x8t3lf1x 256 111 of of IN cord-016652-x8t3lf1x 256 112 B23 B23 NNP cord-016652-x8t3lf1x 256 113 and and CC cord-016652-x8t3lf1x 256 114 in in IN cord-016652-x8t3lf1x 256 115 nuclear nuclear JJ cord-016652-x8t3lf1x 256 116 egress egress NN cord-016652-x8t3lf1x 257 1 The the DT cord-016652-x8t3lf1x 257 2 products product NNS cord-016652-x8t3lf1x 257 3 of of IN cord-016652-x8t3lf1x 257 4 gene gene NN cord-016652-x8t3lf1x 257 5 US11 US11 NNP cord-016652-x8t3lf1x 257 6 of of IN cord-016652-x8t3lf1x 257 7 herpes herpes NNP cord-016652-x8t3lf1x 257 8 simplex simplex NNP cord-016652-x8t3lf1x 257 9 virus virus NN cord-016652-x8t3lf1x 257 10 type type NN cord-016652-x8t3lf1x 257 11 1 1 CD cord-016652-x8t3lf1x 257 12 are be VBP cord-016652-x8t3lf1x 257 13 DNA dna NN cord-016652-x8t3lf1x 257 14 - - HYPH cord-016652-x8t3lf1x 257 15 binding binding NN cord-016652-x8t3lf1x 257 16 and and CC cord-016652-x8t3lf1x 257 17 localize localize VB cord-016652-x8t3lf1x 257 18 to to IN cord-016652-x8t3lf1x 257 19 the the DT cord-016652-x8t3lf1x 257 20 nucleoli nucleoli NNP cord-016652-x8t3lf1x 257 21 of of IN cord-016652-x8t3lf1x 257 22 infected infected JJ cord-016652-x8t3lf1x 257 23 cells cell NNS cord-016652-x8t3lf1x 257 24 Stable stable JJ cord-016652-x8t3lf1x 257 25 expression expression NN cord-016652-x8t3lf1x 257 26 of of IN cord-016652-x8t3lf1x 257 27 hepatitis hepatitis NNP cord-016652-x8t3lf1x 257 28 delta delta NNP cord-016652-x8t3lf1x 257 29 virus virus NN cord-016652-x8t3lf1x 257 30 antigen antigen NN cord-016652-x8t3lf1x 257 31 in in IN cord-016652-x8t3lf1x 257 32 a a DT cord-016652-x8t3lf1x 257 33 eukaryotic eukaryotic JJ cord-016652-x8t3lf1x 257 34 cell cell NN cord-016652-x8t3lf1x 257 35 line line NN cord-016652-x8t3lf1x 257 36 Adenovirus Adenovirus NNP cord-016652-x8t3lf1x 257 37 core core NN cord-016652-x8t3lf1x 257 38 protein protein NN cord-016652-x8t3lf1x 257 39 V v NN cord-016652-x8t3lf1x 257 40 is be VBZ cord-016652-x8t3lf1x 257 41 delivered deliver VBN cord-016652-x8t3lf1x 257 42 by by IN cord-016652-x8t3lf1x 257 43 the the DT cord-016652-x8t3lf1x 257 44 invading invade VBG cord-016652-x8t3lf1x 257 45 virus virus NN cord-016652-x8t3lf1x 257 46 to to IN cord-016652-x8t3lf1x 257 47 the the DT cord-016652-x8t3lf1x 257 48 nucleus nucleus NN cord-016652-x8t3lf1x 257 49 of of IN cord-016652-x8t3lf1x 257 50 the the DT cord-016652-x8t3lf1x 257 51 infected infected JJ cord-016652-x8t3lf1x 257 52 cell cell NN cord-016652-x8t3lf1x 257 53 and and CC cord-016652-x8t3lf1x 257 54 later later RB cord-016652-x8t3lf1x 257 55 in in IN cord-016652-x8t3lf1x 257 56 infection infection NN cord-016652-x8t3lf1x 257 57 is be VBZ cord-016652-x8t3lf1x 257 58 associated associate VBN cord-016652-x8t3lf1x 257 59 with with IN cord-016652-x8t3lf1x 257 60 nucleoli nucleoli NNP cord-016652-x8t3lf1x 257 61 Cellular Cellular NNP cord-016652-x8t3lf1x 257 62 stress stress NN cord-016652-x8t3lf1x 257 63 and and CC cord-016652-x8t3lf1x 257 64 nucleolar nucleolar JJ cord-016652-x8t3lf1x 257 65 function function NN cord-016652-x8t3lf1x 257 66 Identification Identification NNP cord-016652-x8t3lf1x 257 67 of of IN cord-016652-x8t3lf1x 257 68 nuclear nuclear JJ cord-016652-x8t3lf1x 257 69 and and CC cord-016652-x8t3lf1x 257 70 nucleolar nucleolar JJ cord-016652-x8t3lf1x 257 71 localization localization NN cord-016652-x8t3lf1x 257 72 signals signal NNS cord-016652-x8t3lf1x 257 73 in in IN cord-016652-x8t3lf1x 257 74 the the DT cord-016652-x8t3lf1x 257 75 herpes herpes NNP cord-016652-x8t3lf1x 257 76 simplex simplex NNP cord-016652-x8t3lf1x 257 77 virus virus NN cord-016652-x8t3lf1x 257 78 regulatory regulatory JJ cord-016652-x8t3lf1x 257 79 protein protein NN cord-016652-x8t3lf1x 257 80 ICP27 ICP27 NNP cord-016652-x8t3lf1x 257 81 Nuclear Nuclear NNP cord-016652-x8t3lf1x 257 82 and and CC cord-016652-x8t3lf1x 257 83 nucleolar nucleolar JJ cord-016652-x8t3lf1x 257 84 targeting target VBG cord-016652-x8t3lf1x 257 85 of of IN cord-016652-x8t3lf1x 257 86 influenza influenza NN cord-016652-x8t3lf1x 257 87 A a DT cord-016652-x8t3lf1x 257 88 virus virus NN cord-016652-x8t3lf1x 257 89 NS1 ns1 NN cord-016652-x8t3lf1x 257 90 protein protein NN cord-016652-x8t3lf1x 257 91 : : : cord-016652-x8t3lf1x 257 92 striking strike VBG cord-016652-x8t3lf1x 257 93 differences difference NNS cord-016652-x8t3lf1x 257 94 between between IN cord-016652-x8t3lf1x 257 95 different different JJ cord-016652-x8t3lf1x 257 96 virus virus NN cord-016652-x8t3lf1x 257 97 subtypes subtypes NN cord-016652-x8t3lf1x 257 98 Karyophilic Karyophilic NNP cord-016652-x8t3lf1x 257 99 properties property NNS cord-016652-x8t3lf1x 257 100 of of IN cord-016652-x8t3lf1x 257 101 Semliki Semliki NNP cord-016652-x8t3lf1x 257 102 Forest Forest NNP cord-016652-x8t3lf1x 257 103 virus virus NN cord-016652-x8t3lf1x 257 104 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 257 105 protein protein NN cord-016652-x8t3lf1x 257 106 Ribozyme Ribozyme NNPS cord-016652-x8t3lf1x 257 107 - - HYPH cord-016652-x8t3lf1x 257 108 mediated mediate VBN cord-016652-x8t3lf1x 257 109 inhibition inhibition NN cord-016652-x8t3lf1x 257 110 of of IN cord-016652-x8t3lf1x 257 111 HIV HIV NNP cord-016652-x8t3lf1x 257 112 1 1 CD cord-016652-x8t3lf1x 257 113 suggests suggest VBZ cord-016652-x8t3lf1x 257 114 nucleolar nucleolar JJ cord-016652-x8t3lf1x 257 115 trafficking trafficking NN cord-016652-x8t3lf1x 257 116 of of IN cord-016652-x8t3lf1x 257 117 HIV-1 HIV-1 NNP cord-016652-x8t3lf1x 257 118 RNA RNA NNP cord-016652-x8t3lf1x 257 119 Localization Localization NNP cord-016652-x8t3lf1x 257 120 and and CC cord-016652-x8t3lf1x 257 121 importance importance NN cord-016652-x8t3lf1x 257 122 of of IN cord-016652-x8t3lf1x 257 123 the the DT cord-016652-x8t3lf1x 257 124 adenovirus adenovirus NN cord-016652-x8t3lf1x 258 1 E4orf4 e4orf4 NN cord-016652-x8t3lf1x 258 2 protein protein NN cord-016652-x8t3lf1x 258 3 during during IN cord-016652-x8t3lf1x 258 4 lytic lytic JJ cord-016652-x8t3lf1x 258 5 infection infection NN cord-016652-x8t3lf1x 259 1 The the DT cord-016652-x8t3lf1x 259 2 lactate lactate NN cord-016652-x8t3lf1x 259 3 dehydrogenase dehydrogenase NN cord-016652-x8t3lf1x 259 4 - - HYPH cord-016652-x8t3lf1x 259 5 elevating elevate VBG cord-016652-x8t3lf1x 259 6 virus virus NN cord-016652-x8t3lf1x 259 7 capsid capsid NN cord-016652-x8t3lf1x 259 8 protein protein NN cord-016652-x8t3lf1x 259 9 is be VBZ cord-016652-x8t3lf1x 259 10 a a DT cord-016652-x8t3lf1x 259 11 nuclear nuclear JJ cord-016652-x8t3lf1x 259 12 - - HYPH cord-016652-x8t3lf1x 259 13 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 259 14 protein protein NN cord-016652-x8t3lf1x 259 15 The the DT cord-016652-x8t3lf1x 259 16 protein protein NN cord-016652-x8t3lf1x 259 17 ICP0 ICP0 NNP cord-016652-x8t3lf1x 259 18 of of IN cord-016652-x8t3lf1x 259 19 herpes herpes NNP cord-016652-x8t3lf1x 259 20 simplex simplex NNP cord-016652-x8t3lf1x 259 21 virus virus NN cord-016652-x8t3lf1x 259 22 type type NN cord-016652-x8t3lf1x 259 23 1 1 CD cord-016652-x8t3lf1x 259 24 is be VBZ cord-016652-x8t3lf1x 259 25 targeted target VBN cord-016652-x8t3lf1x 259 26 to to IN cord-016652-x8t3lf1x 259 27 nucleoli nucleoli NNP cord-016652-x8t3lf1x 259 28 of of IN cord-016652-x8t3lf1x 259 29 infected infected JJ cord-016652-x8t3lf1x 259 30 cells cell NNS cord-016652-x8t3lf1x 259 31 Nuclear nuclear JJ cord-016652-x8t3lf1x 259 32 localization localization NN cord-016652-x8t3lf1x 259 33 of of IN cord-016652-x8t3lf1x 259 34 Japanese japanese JJ cord-016652-x8t3lf1x 259 35 encephalitis encephalitis RB cord-016652-x8t3lf1x 259 36 virus virus NN cord-016652-x8t3lf1x 259 37 core core NN cord-016652-x8t3lf1x 259 38 protein protein NN cord-016652-x8t3lf1x 259 39 enhances enhance VBZ cord-016652-x8t3lf1x 259 40 viral viral JJ cord-016652-x8t3lf1x 259 41 replication replication NN cord-016652-x8t3lf1x 259 42 Quantitative quantitative JJ cord-016652-x8t3lf1x 259 43 proteomic proteomic JJ cord-016652-x8t3lf1x 259 44 analysis analysis NN cord-016652-x8t3lf1x 259 45 of of IN cord-016652-x8t3lf1x 259 46 A549 A549 NNP cord-016652-x8t3lf1x 259 47 cells cell NNS cord-016652-x8t3lf1x 259 48 infected infect VBN cord-016652-x8t3lf1x 259 49 with with IN cord-016652-x8t3lf1x 259 50 human human JJ cord-016652-x8t3lf1x 259 51 respiratory respiratory JJ cord-016652-x8t3lf1x 259 52 syncytial syncytial JJ cord-016652-x8t3lf1x 259 53 virus virus NN cord-016652-x8t3lf1x 259 54 Functional functional JJ cord-016652-x8t3lf1x 259 55 domain domain NN cord-016652-x8t3lf1x 259 56 structure structure NN cord-016652-x8t3lf1x 259 57 of of IN cord-016652-x8t3lf1x 259 58 human human JJ cord-016652-x8t3lf1x 259 59 T t NN cord-016652-x8t3lf1x 259 60 - - HYPH cord-016652-x8t3lf1x 259 61 cell cell NN cord-016652-x8t3lf1x 259 62 leukemia leukemia NN cord-016652-x8t3lf1x 259 63 virus virus NN cord-016652-x8t3lf1x 259 64 type type NN cord-016652-x8t3lf1x 259 65 2 2 CD cord-016652-x8t3lf1x 259 66 rex rex NNP cord-016652-x8t3lf1x 259 67 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 259 68 localization localization NN cord-016652-x8t3lf1x 259 69 of of IN cord-016652-x8t3lf1x 259 70 human human JJ cord-016652-x8t3lf1x 259 71 hepatitis hepatitis NN cord-016652-x8t3lf1x 259 72 B B NNP cord-016652-x8t3lf1x 259 73 virus virus NN cord-016652-x8t3lf1x 259 74 capsid capsid NN cord-016652-x8t3lf1x 259 75 protein protein NN cord-016652-x8t3lf1x 259 76 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 259 77 targeting target VBG cord-016652-x8t3lf1x 259 78 signal signal NN cord-016652-x8t3lf1x 259 79 of of IN cord-016652-x8t3lf1x 259 80 human human JJ cord-016652-x8t3lf1x 259 81 T t NN cord-016652-x8t3lf1x 259 82 - - HYPH cord-016652-x8t3lf1x 259 83 cell cell NN cord-016652-x8t3lf1x 259 84 leukemia leukemia NN cord-016652-x8t3lf1x 259 85 virus virus NN cord-016652-x8t3lf1x 259 86 type type NN cord-016652-x8t3lf1x 260 1 I -PRON- PRP cord-016652-x8t3lf1x 260 2 rex rex NNP cord-016652-x8t3lf1x 260 3 - - HYPH cord-016652-x8t3lf1x 260 4 encoded encode VBN cord-016652-x8t3lf1x 260 5 protein protein NN cord-016652-x8t3lf1x 260 6 is be VBZ cord-016652-x8t3lf1x 260 7 essential essential JJ cord-016652-x8t3lf1x 260 8 for for IN cord-016652-x8t3lf1x 260 9 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 260 10 accumulation accumulation NN cord-016652-x8t3lf1x 260 11 of of IN cord-016652-x8t3lf1x 260 12 unspliced unsplice VBN cord-016652-x8t3lf1x 260 13 viral viral JJ cord-016652-x8t3lf1x 260 14 mRNA mRNA NNP cord-016652-x8t3lf1x 260 15 Identification Identification NNP cord-016652-x8t3lf1x 260 16 of of IN cord-016652-x8t3lf1x 260 17 nucleophosmin nucleophosmin NNP cord-016652-x8t3lf1x 260 18 / / SYM cord-016652-x8t3lf1x 260 19 B23 B23 NNP cord-016652-x8t3lf1x 260 20 , , , cord-016652-x8t3lf1x 260 21 an an DT cord-016652-x8t3lf1x 260 22 acidic acidic JJ cord-016652-x8t3lf1x 260 23 nucleolar nucleolar JJ cord-016652-x8t3lf1x 260 24 protein protein NN cord-016652-x8t3lf1x 260 25 , , , cord-016652-x8t3lf1x 260 26 as as IN cord-016652-x8t3lf1x 260 27 a a DT cord-016652-x8t3lf1x 260 28 stimulatory stimulatory JJ cord-016652-x8t3lf1x 260 29 factor factor NN cord-016652-x8t3lf1x 260 30 for for IN cord-016652-x8t3lf1x 260 31 in in IN cord-016652-x8t3lf1x 260 32 vitro vitro FW cord-016652-x8t3lf1x 260 33 replication replication NN cord-016652-x8t3lf1x 260 34 of of IN cord-016652-x8t3lf1x 260 35 adenovirus adenovirus NN cord-016652-x8t3lf1x 260 36 DNA dna NN cord-016652-x8t3lf1x 260 37 complexed complexe VBN cord-016652-x8t3lf1x 260 38 with with IN cord-016652-x8t3lf1x 260 39 viral viral JJ cord-016652-x8t3lf1x 260 40 basic basic JJ cord-016652-x8t3lf1x 260 41 core core NN cord-016652-x8t3lf1x 260 42 proteins protein NNS cord-016652-x8t3lf1x 260 43 Induction Induction NNP cord-016652-x8t3lf1x 260 44 of of IN cord-016652-x8t3lf1x 260 45 apoptosis apoptosis NN cord-016652-x8t3lf1x 260 46 by by IN cord-016652-x8t3lf1x 260 47 viruses virus NNS cord-016652-x8t3lf1x 260 48 : : : cord-016652-x8t3lf1x 260 49 what what WDT cord-016652-x8t3lf1x 260 50 role role NN cord-016652-x8t3lf1x 260 51 does do VBZ cord-016652-x8t3lf1x 260 52 the the DT cord-016652-x8t3lf1x 260 53 nucleolus nucleolus NN cord-016652-x8t3lf1x 260 54 play play VB cord-016652-x8t3lf1x 260 55 ? ? . cord-016652-x8t3lf1x 261 1 Inhibition inhibition NN cord-016652-x8t3lf1x 261 2 of of IN cord-016652-x8t3lf1x 261 3 human human JJ cord-016652-x8t3lf1x 261 4 immunodeficiency immunodeficiency NN cord-016652-x8t3lf1x 261 5 virus virus NN cord-016652-x8t3lf1x 261 6 type type NN cord-016652-x8t3lf1x 261 7 1 1 CD cord-016652-x8t3lf1x 261 8 and and CC cord-016652-x8t3lf1x 261 9 type type NN cord-016652-x8t3lf1x 261 10 2 2 CD cord-016652-x8t3lf1x 261 11 Tat tat NN cord-016652-x8t3lf1x 261 12 function function NN cord-016652-x8t3lf1x 261 13 by by IN cord-016652-x8t3lf1x 261 14 transdominant transdominant JJ cord-016652-x8t3lf1x 261 15 Tat Tat NNP cord-016652-x8t3lf1x 261 16 protein protein NN cord-016652-x8t3lf1x 261 17 localized localize VBN cord-016652-x8t3lf1x 261 18 to to IN cord-016652-x8t3lf1x 261 19 both both CC cord-016652-x8t3lf1x 261 20 the the DT cord-016652-x8t3lf1x 261 21 nucleus nucleus NN cord-016652-x8t3lf1x 261 22 and and CC cord-016652-x8t3lf1x 261 23 cytoplasm cytoplasm JJ cord-016652-x8t3lf1x 261 24 Nuclear nuclear JJ cord-016652-x8t3lf1x 261 25 entry entry NN cord-016652-x8t3lf1x 261 26 and and CC cord-016652-x8t3lf1x 261 27 nucleolar nucleolar JJ cord-016652-x8t3lf1x 261 28 localization localization NN cord-016652-x8t3lf1x 261 29 of of IN cord-016652-x8t3lf1x 261 30 the the DT cord-016652-x8t3lf1x 261 31 Newcastle Newcastle NNP cord-016652-x8t3lf1x 261 32 disease disease NN cord-016652-x8t3lf1x 261 33 virus virus NN cord-016652-x8t3lf1x 262 1 ( ( -LRB- cord-016652-x8t3lf1x 262 2 NDV NDV NNP cord-016652-x8t3lf1x 262 3 ) ) -RRB- cord-016652-x8t3lf1x 262 4 matrix matrix NN cord-016652-x8t3lf1x 262 5 protein protein NN cord-016652-x8t3lf1x 262 6 occur occur VBP cord-016652-x8t3lf1x 262 7 early early RB cord-016652-x8t3lf1x 262 8 in in IN cord-016652-x8t3lf1x 262 9 infection infection NN cord-016652-x8t3lf1x 262 10 and and CC cord-016652-x8t3lf1x 262 11 do do VBP cord-016652-x8t3lf1x 262 12 not not RB cord-016652-x8t3lf1x 262 13 require require VB cord-016652-x8t3lf1x 262 14 other other JJ cord-016652-x8t3lf1x 262 15 NDV NDV NNP cord-016652-x8t3lf1x 262 16 proteins protein NNS cord-016652-x8t3lf1x 262 17 Functional functional JJ cord-016652-x8t3lf1x 262 18 mapping mapping NN cord-016652-x8t3lf1x 262 19 of of IN cord-016652-x8t3lf1x 262 20 the the DT cord-016652-x8t3lf1x 262 21 porcine porcine JJ cord-016652-x8t3lf1x 262 22 reproductive reproductive JJ cord-016652-x8t3lf1x 262 23 and and CC cord-016652-x8t3lf1x 262 24 respiratory respiratory JJ cord-016652-x8t3lf1x 262 25 syndrome syndrome NN cord-016652-x8t3lf1x 262 26 virus virus NN cord-016652-x8t3lf1x 262 27 capsid capsid NN cord-016652-x8t3lf1x 262 28 protein protein NN cord-016652-x8t3lf1x 262 29 nuclear nuclear JJ cord-016652-x8t3lf1x 262 30 localization localization NN cord-016652-x8t3lf1x 262 31 signal signal NN cord-016652-x8t3lf1x 262 32 and and CC cord-016652-x8t3lf1x 262 33 its -PRON- PRP$ cord-016652-x8t3lf1x 262 34 pathogenic pathogenic JJ cord-016652-x8t3lf1x 262 35 association association NN cord-016652-x8t3lf1x 262 36 Nuclear nuclear JJ cord-016652-x8t3lf1x 262 37 localization localization NN cord-016652-x8t3lf1x 262 38 of of IN cord-016652-x8t3lf1x 262 39 Semliki Semliki NNP cord-016652-x8t3lf1x 262 40 Forest Forest NNP cord-016652-x8t3lf1x 262 41 virus virus NN cord-016652-x8t3lf1x 262 42 - - HYPH cord-016652-x8t3lf1x 262 43 specific specific JJ cord-016652-x8t3lf1x 262 44 nonstructural nonstructural JJ cord-016652-x8t3lf1x 262 45 protein protein NN cord-016652-x8t3lf1x 263 1 nsP2 nsP2 . cord-016652-x8t3lf1x 264 1 The the DT cord-016652-x8t3lf1x 264 2 nucleolus nucleolus NN cord-016652-x8t3lf1x 264 3 is be VBZ cord-016652-x8t3lf1x 264 4 the the DT cord-016652-x8t3lf1x 264 5 site site NN cord-016652-x8t3lf1x 264 6 of of IN cord-016652-x8t3lf1x 264 7 Borna Borna NNP cord-016652-x8t3lf1x 264 8 disease disease NN cord-016652-x8t3lf1x 264 9 virus virus NN cord-016652-x8t3lf1x 264 10 RNA rna NN cord-016652-x8t3lf1x 264 11 transcription transcription NN cord-016652-x8t3lf1x 264 12 and and CC cord-016652-x8t3lf1x 264 13 replication replication NN cord-016652-x8t3lf1x 265 1 The the DT cord-016652-x8t3lf1x 265 2 complex complex JJ cord-016652-x8t3lf1x 265 3 subcellular subcellular JJ cord-016652-x8t3lf1x 265 4 distribution distribution NN cord-016652-x8t3lf1x 265 5 of of IN cord-016652-x8t3lf1x 265 6 satellite satellite NN cord-016652-x8t3lf1x 265 7 panicum panicum NN cord-016652-x8t3lf1x 265 8 mosaic mosaic NN cord-016652-x8t3lf1x 265 9 virus virus NN cord-016652-x8t3lf1x 265 10 capsid capsid NN cord-016652-x8t3lf1x 265 11 protein protein NN cord-016652-x8t3lf1x 265 12 reflects reflect VBZ cord-016652-x8t3lf1x 265 13 its -PRON- PRP$ cord-016652-x8t3lf1x 265 14 multifunctional multifunctional JJ cord-016652-x8t3lf1x 265 15 role role NN cord-016652-x8t3lf1x 265 16 during during IN cord-016652-x8t3lf1x 265 17 infection infection NN cord-016652-x8t3lf1x 265 18 Control Control NNP cord-016652-x8t3lf1x 265 19 of of IN cord-016652-x8t3lf1x 265 20 nuclear nuclear JJ cord-016652-x8t3lf1x 265 21 and and CC cord-016652-x8t3lf1x 265 22 nucleolar nucleolar JJ cord-016652-x8t3lf1x 265 23 localization localization NN cord-016652-x8t3lf1x 265 24 of of IN cord-016652-x8t3lf1x 265 25 nuclear nuclear JJ cord-016652-x8t3lf1x 265 26 inclusion inclusion NN cord-016652-x8t3lf1x 265 27 protein protein NN cord-016652-x8t3lf1x 265 28 a a DT cord-016652-x8t3lf1x 265 29 of of IN cord-016652-x8t3lf1x 265 30 picorna picorna NNP cord-016652-x8t3lf1x 265 31 - - HYPH cord-016652-x8t3lf1x 265 32 like like JJ cord-016652-x8t3lf1x 265 33 Potato Potato NNP cord-016652-x8t3lf1x 265 34 virus virus NN cord-016652-x8t3lf1x 265 35 A a NN cord-016652-x8t3lf1x 265 36 in in IN cord-016652-x8t3lf1x 265 37 Nicotiana Nicotiana NNP cord-016652-x8t3lf1x 265 38 species specie NNS cord-016652-x8t3lf1x 266 1 Proapoptotic proapoptotic JJ cord-016652-x8t3lf1x 266 2 effect effect NN cord-016652-x8t3lf1x 266 3 of of IN cord-016652-x8t3lf1x 266 4 hepatitis hepatitis NN cord-016652-x8t3lf1x 266 5 C C NNP cord-016652-x8t3lf1x 266 6 virus virus NN cord-016652-x8t3lf1x 266 7 CORE core NN cord-016652-x8t3lf1x 266 8 protein protein NN cord-016652-x8t3lf1x 266 9 in in IN cord-016652-x8t3lf1x 266 10 transiently transiently RB cord-016652-x8t3lf1x 266 11 transfected transfecte VBN cord-016652-x8t3lf1x 266 12 cells cell NNS cord-016652-x8t3lf1x 266 13 is be VBZ cord-016652-x8t3lf1x 266 14 enhanced enhance VBN cord-016652-x8t3lf1x 266 15 by by IN cord-016652-x8t3lf1x 266 16 nuclear nuclear JJ cord-016652-x8t3lf1x 266 17 localization localization NN cord-016652-x8t3lf1x 266 18 and and CC cord-016652-x8t3lf1x 266 19 is be VBZ cord-016652-x8t3lf1x 266 20 dependent dependent JJ cord-016652-x8t3lf1x 266 21 on on IN cord-016652-x8t3lf1x 266 22 PKR PKR NNP cord-016652-x8t3lf1x 266 23 activation activation NN cord-016652-x8t3lf1x 266 24 Delineation delineation NN cord-016652-x8t3lf1x 266 25 and and CC cord-016652-x8t3lf1x 266 26 modelling modelling NN cord-016652-x8t3lf1x 266 27 of of IN cord-016652-x8t3lf1x 266 28 a a DT cord-016652-x8t3lf1x 266 29 nucleolar nucleolar JJ cord-016652-x8t3lf1x 266 30 retention retention NN cord-016652-x8t3lf1x 266 31 signal signal NN cord-016652-x8t3lf1x 266 32 in in IN cord-016652-x8t3lf1x 266 33 the the DT cord-016652-x8t3lf1x 266 34 coronavirus coronavirus NN cord-016652-x8t3lf1x 266 35 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 266 36 protein protein NN cord-016652-x8t3lf1x 266 37 Characterization characterization NN cord-016652-x8t3lf1x 266 38 of of IN cord-016652-x8t3lf1x 266 39 the the DT cord-016652-x8t3lf1x 266 40 nuclear nuclear JJ cord-016652-x8t3lf1x 266 41 export export NN cord-016652-x8t3lf1x 266 42 signal signal NN cord-016652-x8t3lf1x 266 43 in in IN cord-016652-x8t3lf1x 266 44 the the DT cord-016652-x8t3lf1x 266 45 coronavirus coronavirus NN cord-016652-x8t3lf1x 266 46 infectious infectious JJ cord-016652-x8t3lf1x 266 47 bronchitis bronchitis NN cord-016652-x8t3lf1x 266 48 virus virus NN cord-016652-x8t3lf1x 266 49 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 266 50 protein protein NNP cord-016652-x8t3lf1x 266 51 Nuclear Nuclear NNP cord-016652-x8t3lf1x 266 52 and and CC cord-016652-x8t3lf1x 266 53 nucleolar nucleolar JJ cord-016652-x8t3lf1x 266 54 targeting target VBG cord-016652-x8t3lf1x 266 55 signals signal NNS cord-016652-x8t3lf1x 266 56 of of IN cord-016652-x8t3lf1x 266 57 Semliki Semliki NNP cord-016652-x8t3lf1x 266 58 Forest Forest NNP cord-016652-x8t3lf1x 266 59 virus virus NN cord-016652-x8t3lf1x 266 60 nonstructural nonstructural JJ cord-016652-x8t3lf1x 266 61 protein protein NN cord-016652-x8t3lf1x 267 1 nsP2 nsp2 LS cord-016652-x8t3lf1x 267 2 Nuclear nuclear JJ cord-016652-x8t3lf1x 267 3 targeting targeting NN cord-016652-x8t3lf1x 267 4 of of IN cord-016652-x8t3lf1x 267 5 Semliki Semliki NNP cord-016652-x8t3lf1x 267 6 Forest Forest NNP cord-016652-x8t3lf1x 267 7 virus virus NN cord-016652-x8t3lf1x 268 1 nsP2 nsP2 NNP cord-016652-x8t3lf1x 268 2 Intracellular Intracellular NNP cord-016652-x8t3lf1x 268 3 transport transport NN cord-016652-x8t3lf1x 268 4 of of IN cord-016652-x8t3lf1x 268 5 the the DT cord-016652-x8t3lf1x 268 6 murine murine JJ cord-016652-x8t3lf1x 268 7 leukemia leukemia NN cord-016652-x8t3lf1x 268 8 virus virus NN cord-016652-x8t3lf1x 268 9 during during IN cord-016652-x8t3lf1x 268 10 acute acute JJ cord-016652-x8t3lf1x 268 11 infection infection NN cord-016652-x8t3lf1x 268 12 of of IN cord-016652-x8t3lf1x 268 13 NIH NIH NNP cord-016652-x8t3lf1x 268 14 3T3 3t3 CD cord-016652-x8t3lf1x 268 15 cells cell NNS cord-016652-x8t3lf1x 268 16 : : : cord-016652-x8t3lf1x 268 17 nuclear nuclear JJ cord-016652-x8t3lf1x 268 18 import import NN cord-016652-x8t3lf1x 268 19 of of IN cord-016652-x8t3lf1x 268 20 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 268 21 protein protein NN cord-016652-x8t3lf1x 268 22 and and CC cord-016652-x8t3lf1x 268 23 integrase integrase VB cord-016652-x8t3lf1x 268 24 Functional functional JJ cord-016652-x8t3lf1x 268 25 analysis analysis NN cord-016652-x8t3lf1x 268 26 of of IN cord-016652-x8t3lf1x 268 27 proteins protein NNS cord-016652-x8t3lf1x 268 28 involved involve VBN cord-016652-x8t3lf1x 268 29 in in IN cord-016652-x8t3lf1x 268 30 movement movement NN cord-016652-x8t3lf1x 268 31 of of IN cord-016652-x8t3lf1x 268 32 the the DT cord-016652-x8t3lf1x 268 33 monopartite monopartite NNP cord-016652-x8t3lf1x 268 34 begomovirus begomovirus NNP cord-016652-x8t3lf1x 268 35 , , , cord-016652-x8t3lf1x 268 36 Tomato Tomato NNP cord-016652-x8t3lf1x 268 37 yellow yellow JJ cord-016652-x8t3lf1x 268 38 leaf leaf NN cord-016652-x8t3lf1x 268 39 curl curl NN cord-016652-x8t3lf1x 268 40 virus virus NN cord-016652-x8t3lf1x 268 41 Genetic genetic JJ cord-016652-x8t3lf1x 268 42 therapies therapy NNS cord-016652-x8t3lf1x 268 43 against against IN cord-016652-x8t3lf1x 268 44 HIV HIV NNP cord-016652-x8t3lf1x 268 45 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 268 46 - - HYPH cord-016652-x8t3lf1x 268 47 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 268 48 shuttling shuttling NN cord-016652-x8t3lf1x 268 49 of of IN cord-016652-x8t3lf1x 268 50 PRRSV PRRSV NNP cord-016652-x8t3lf1x 268 51 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 268 52 protein protein NNP cord-016652-x8t3lf1x 268 53 : : : cord-016652-x8t3lf1x 268 54 a a DT cord-016652-x8t3lf1x 268 55 simple simple JJ cord-016652-x8t3lf1x 268 56 case case NN cord-016652-x8t3lf1x 268 57 of of IN cord-016652-x8t3lf1x 268 58 molecular molecular JJ cord-016652-x8t3lf1x 268 59 mimicry mimicry NN cord-016652-x8t3lf1x 268 60 or or CC cord-016652-x8t3lf1x 268 61 the the DT cord-016652-x8t3lf1x 268 62 complex complex JJ cord-016652-x8t3lf1x 268 63 regulation regulation NN cord-016652-x8t3lf1x 268 64 by by IN cord-016652-x8t3lf1x 268 65 nuclear nuclear JJ cord-016652-x8t3lf1x 268 66 import import NN cord-016652-x8t3lf1x 268 67 , , , cord-016652-x8t3lf1x 268 68 nucleolar nucleolar JJ cord-016652-x8t3lf1x 268 69 localization localization NN cord-016652-x8t3lf1x 268 70 and and CC cord-016652-x8t3lf1x 268 71 nuclear nuclear JJ cord-016652-x8t3lf1x 268 72 export export NN cord-016652-x8t3lf1x 268 73 signal signal NN cord-016652-x8t3lf1x 268 74 sequences sequence NNS cord-016652-x8t3lf1x 269 1 The the DT cord-016652-x8t3lf1x 269 2 localisation localisation NN cord-016652-x8t3lf1x 269 3 of of IN cord-016652-x8t3lf1x 269 4 porcine porcine JJ cord-016652-x8t3lf1x 269 5 reproductive reproductive JJ cord-016652-x8t3lf1x 269 6 and and CC cord-016652-x8t3lf1x 269 7 respiratory respiratory JJ cord-016652-x8t3lf1x 269 8 syndrome syndrome NN cord-016652-x8t3lf1x 269 9 virus virus NN cord-016652-x8t3lf1x 269 10 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 269 11 protein protein NN cord-016652-x8t3lf1x 269 12 to to IN cord-016652-x8t3lf1x 269 13 the the DT cord-016652-x8t3lf1x 269 14 nucleolus nucleolus NN cord-016652-x8t3lf1x 269 15 of of IN cord-016652-x8t3lf1x 269 16 infected infected JJ cord-016652-x8t3lf1x 269 17 cells cell NNS cord-016652-x8t3lf1x 269 18 and and CC cord-016652-x8t3lf1x 269 19 identification identification NN cord-016652-x8t3lf1x 269 20 of of IN cord-016652-x8t3lf1x 269 21 a a DT cord-016652-x8t3lf1x 269 22 potential potential JJ cord-016652-x8t3lf1x 269 23 nucleolar nucleolar JJ cord-016652-x8t3lf1x 269 24 localization localization NN cord-016652-x8t3lf1x 269 25 signal signal NN cord-016652-x8t3lf1x 269 26 sequence sequence NN cord-016652-x8t3lf1x 269 27 Peptide peptide NN cord-016652-x8t3lf1x 269 28 domains domain NNS cord-016652-x8t3lf1x 269 29 involved involve VBN cord-016652-x8t3lf1x 269 30 in in IN cord-016652-x8t3lf1x 269 31 the the DT cord-016652-x8t3lf1x 269 32 localization localization NN cord-016652-x8t3lf1x 269 33 of of IN cord-016652-x8t3lf1x 269 34 the the DT cord-016652-x8t3lf1x 269 35 porcine porcine JJ cord-016652-x8t3lf1x 269 36 reproductive reproductive JJ cord-016652-x8t3lf1x 269 37 and and CC cord-016652-x8t3lf1x 269 38 respiratory respiratory JJ cord-016652-x8t3lf1x 269 39 syndrome syndrome NN cord-016652-x8t3lf1x 269 40 virus virus NN cord-016652-x8t3lf1x 269 41 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 269 42 protein protein NN cord-016652-x8t3lf1x 269 43 to to IN cord-016652-x8t3lf1x 269 44 the the DT cord-016652-x8t3lf1x 269 45 nucleolus nucleolus NN cord-016652-x8t3lf1x 269 46 Structural structural JJ cord-016652-x8t3lf1x 269 47 and and CC cord-016652-x8t3lf1x 269 48 functional functional JJ cord-016652-x8t3lf1x 269 49 characterization characterization NN cord-016652-x8t3lf1x 269 50 of of IN cord-016652-x8t3lf1x 269 51 human human JJ cord-016652-x8t3lf1x 269 52 immunodeficiency immunodeficiency NN cord-016652-x8t3lf1x 269 53 virus virus NN cord-016652-x8t3lf1x 269 54 tat tat NN cord-016652-x8t3lf1x 269 55 protein protein NN cord-016652-x8t3lf1x 269 56 Human human JJ cord-016652-x8t3lf1x 269 57 endogenous endogenous JJ cord-016652-x8t3lf1x 269 58 retrovirus retrovirus NN cord-016652-x8t3lf1x 269 59 HERV HERV NNP cord-016652-x8t3lf1x 269 60 - - HYPH cord-016652-x8t3lf1x 269 61 K(HML-2 K(HML-2 NNP cord-016652-x8t3lf1x 269 62 ) ) -RRB- cord-016652-x8t3lf1x 269 63 encodes encode VBZ cord-016652-x8t3lf1x 269 64 a a DT cord-016652-x8t3lf1x 269 65 stable stable JJ cord-016652-x8t3lf1x 269 66 signal signal NN cord-016652-x8t3lf1x 269 67 peptide peptide NN cord-016652-x8t3lf1x 269 68 with with IN cord-016652-x8t3lf1x 269 69 biological biological JJ cord-016652-x8t3lf1x 269 70 properties property NNS cord-016652-x8t3lf1x 269 71 distinct distinct JJ cord-016652-x8t3lf1x 269 72 from from IN cord-016652-x8t3lf1x 269 73 Rec Rec NNP cord-016652-x8t3lf1x 269 74 Intracellular Intracellular NNP cord-016652-x8t3lf1x 269 75 location location NN cord-016652-x8t3lf1x 269 76 of of IN cord-016652-x8t3lf1x 269 77 two two CD cord-016652-x8t3lf1x 269 78 groundnut groundnut NN cord-016652-x8t3lf1x 269 79 rosette rosette NN cord-016652-x8t3lf1x 269 80 umbravirus umbravirus NNP cord-016652-x8t3lf1x 269 81 proteins protein NNS cord-016652-x8t3lf1x 269 82 delivered deliver VBN cord-016652-x8t3lf1x 269 83 by by IN cord-016652-x8t3lf1x 269 84 PVX PVX NNP cord-016652-x8t3lf1x 269 85 and and CC cord-016652-x8t3lf1x 269 86 TMV TMV NNP cord-016652-x8t3lf1x 269 87 vectors vector NNS cord-016652-x8t3lf1x 269 88 Identification Identification NNP cord-016652-x8t3lf1x 269 89 of of IN cord-016652-x8t3lf1x 269 90 a a DT cord-016652-x8t3lf1x 269 91 nuclear nuclear JJ cord-016652-x8t3lf1x 269 92 localization localization NN cord-016652-x8t3lf1x 269 93 signal signal NN cord-016652-x8t3lf1x 269 94 and and CC cord-016652-x8t3lf1x 269 95 nuclear nuclear JJ cord-016652-x8t3lf1x 269 96 export export NN cord-016652-x8t3lf1x 269 97 signal signal NN cord-016652-x8t3lf1x 269 98 of of IN cord-016652-x8t3lf1x 269 99 the the DT cord-016652-x8t3lf1x 269 100 umbraviral umbraviral JJ cord-016652-x8t3lf1x 269 101 long long JJ cord-016652-x8t3lf1x 269 102 - - HYPH cord-016652-x8t3lf1x 269 103 distance distance NN cord-016652-x8t3lf1x 269 104 RNA RNA NNP cord-016652-x8t3lf1x 269 105 movement movement NN cord-016652-x8t3lf1x 269 106 protein protein NN cord-016652-x8t3lf1x 270 1 Nucleolin Nucleolin NNP cord-016652-x8t3lf1x 270 2 is be VBZ cord-016652-x8t3lf1x 270 3 required require VBN cord-016652-x8t3lf1x 270 4 for for IN cord-016652-x8t3lf1x 270 5 efficient efficient JJ cord-016652-x8t3lf1x 270 6 nuclear nuclear JJ cord-016652-x8t3lf1x 270 7 egress egress NN cord-016652-x8t3lf1x 270 8 of of IN cord-016652-x8t3lf1x 270 9 herpes herpes NNP cord-016652-x8t3lf1x 270 10 simplex simplex NNP cord-016652-x8t3lf1x 270 11 virus virus NN cord-016652-x8t3lf1x 270 12 type type NN cord-016652-x8t3lf1x 270 13 1 1 CD cord-016652-x8t3lf1x 270 14 nucleocapsids nucleocapsids NNP cord-016652-x8t3lf1x 270 15 Genome Genome NNP cord-016652-x8t3lf1x 270 16 - - HYPH cord-016652-x8t3lf1x 270 17 wide wide JJ cord-016652-x8t3lf1x 270 18 screen screen NN cord-016652-x8t3lf1x 270 19 of of IN cord-016652-x8t3lf1x 270 20 three three CD cord-016652-x8t3lf1x 270 21 herpesviruses herpesviruse NNS cord-016652-x8t3lf1x 270 22 for for IN cord-016652-x8t3lf1x 270 23 protein protein NN cord-016652-x8t3lf1x 270 24 subcellular subcellular JJ cord-016652-x8t3lf1x 270 25 localization localization NN cord-016652-x8t3lf1x 270 26 and and CC cord-016652-x8t3lf1x 270 27 alteration alteration NN cord-016652-x8t3lf1x 270 28 of of IN cord-016652-x8t3lf1x 270 29 PML PML NNP cord-016652-x8t3lf1x 270 30 nuclear nuclear JJ cord-016652-x8t3lf1x 270 31 bodies body NNS cord-016652-x8t3lf1x 270 32 Identification Identification NNP cord-016652-x8t3lf1x 270 33 of of IN cord-016652-x8t3lf1x 270 34 the the DT cord-016652-x8t3lf1x 270 35 caprine caprine NN cord-016652-x8t3lf1x 270 36 arthritis arthritis NN cord-016652-x8t3lf1x 270 37 encephalitis encephalitis NNP cord-016652-x8t3lf1x 270 38 virus virus NN cord-016652-x8t3lf1x 270 39 Rev Rev NNP cord-016652-x8t3lf1x 270 40 protein protein NN cord-016652-x8t3lf1x 270 41 and and CC cord-016652-x8t3lf1x 270 42 its -PRON- PRP$ cord-016652-x8t3lf1x 270 43 cis cis NNP cord-016652-x8t3lf1x 270 44 - - HYPH cord-016652-x8t3lf1x 270 45 acting act VBG cord-016652-x8t3lf1x 270 46 Rev Rev NNP cord-016652-x8t3lf1x 270 47 - - HYPH cord-016652-x8t3lf1x 270 48 responsive responsive JJ cord-016652-x8t3lf1x 270 49 element element NN cord-016652-x8t3lf1x 271 1 The the DT cord-016652-x8t3lf1x 271 2 Rev Rev NNP cord-016652-x8t3lf1x 271 3 protein protein NN cord-016652-x8t3lf1x 271 4 of of IN cord-016652-x8t3lf1x 271 5 visna visna NNP cord-016652-x8t3lf1x 271 6 virus virus NN cord-016652-x8t3lf1x 271 7 is be VBZ cord-016652-x8t3lf1x 271 8 localized localize VBN cord-016652-x8t3lf1x 271 9 to to IN cord-016652-x8t3lf1x 271 10 the the DT cord-016652-x8t3lf1x 271 11 nucleus nucleus NN cord-016652-x8t3lf1x 271 12 of of IN cord-016652-x8t3lf1x 271 13 infected infected JJ cord-016652-x8t3lf1x 271 14 cells cell NNS cord-016652-x8t3lf1x 271 15 PNAC PNAC NNP cord-016652-x8t3lf1x 271 16 : : : cord-016652-x8t3lf1x 271 17 a a DT cord-016652-x8t3lf1x 271 18 protein protein NN cord-016652-x8t3lf1x 271 19 nucleolar nucleolar NNP cord-016652-x8t3lf1x 271 20 association association NNP cord-016652-x8t3lf1x 271 21 classifier classifier NN cord-016652-x8t3lf1x 271 22 Characterization Characterization NNP cord-016652-x8t3lf1x 271 23 of of IN cord-016652-x8t3lf1x 271 24 signals signal NNS cord-016652-x8t3lf1x 271 25 that that WDT cord-016652-x8t3lf1x 271 26 dictate dictate VBP cord-016652-x8t3lf1x 271 27 nuclear nuclear JJ cord-016652-x8t3lf1x 271 28 / / SYM cord-016652-x8t3lf1x 271 29 nucleolar nucleolar JJ cord-016652-x8t3lf1x 271 30 and and CC cord-016652-x8t3lf1x 271 31 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 271 32 shuttling shuttling NN cord-016652-x8t3lf1x 271 33 of of IN cord-016652-x8t3lf1x 271 34 the the DT cord-016652-x8t3lf1x 271 35 capsid capsid JJ cord-016652-x8t3lf1x 271 36 protein protein NN cord-016652-x8t3lf1x 271 37 of of IN cord-016652-x8t3lf1x 271 38 Tomato Tomato NNP cord-016652-x8t3lf1x 271 39 leaf leaf NN cord-016652-x8t3lf1x 271 40 curl curl NN cord-016652-x8t3lf1x 271 41 Java Java NNP cord-016652-x8t3lf1x 271 42 virus virus NN cord-016652-x8t3lf1x 271 43 associated associate VBN cord-016652-x8t3lf1x 271 44 with with IN cord-016652-x8t3lf1x 271 45 DNA dna NN cord-016652-x8t3lf1x 271 46 beta beta NN cord-016652-x8t3lf1x 271 47 satellite satellite NN cord-016652-x8t3lf1x 271 48 Sequence sequence NN cord-016652-x8t3lf1x 271 49 requirements requirement NNS cord-016652-x8t3lf1x 271 50 for for IN cord-016652-x8t3lf1x 271 51 nucleolar nucleolar JJ cord-016652-x8t3lf1x 271 52 localization localization NN cord-016652-x8t3lf1x 271 53 of of IN cord-016652-x8t3lf1x 271 54 human human JJ cord-016652-x8t3lf1x 271 55 T T NNP cord-016652-x8t3lf1x 271 56 cell cell NN cord-016652-x8t3lf1x 271 57 leukemia leukemia NN cord-016652-x8t3lf1x 271 58 virus virus NN cord-016652-x8t3lf1x 271 59 type type NN cord-016652-x8t3lf1x 272 1 I -PRON- PRP cord-016652-x8t3lf1x 272 2 pX px VBP cord-016652-x8t3lf1x 272 3 protein protein NN cord-016652-x8t3lf1x 272 4 , , , cord-016652-x8t3lf1x 272 5 which which WDT cord-016652-x8t3lf1x 272 6 regulates regulate VBZ cord-016652-x8t3lf1x 272 7 viral viral JJ cord-016652-x8t3lf1x 272 8 RNA RNA NNP cord-016652-x8t3lf1x 272 9 processing process VBG cord-016652-x8t3lf1x 272 10 A a DT cord-016652-x8t3lf1x 272 11 viral viral JJ cord-016652-x8t3lf1x 272 12 assembly assembly NN cord-016652-x8t3lf1x 272 13 factor factor NN cord-016652-x8t3lf1x 272 14 promotes promote VBZ cord-016652-x8t3lf1x 272 15 AAV2 AAV2 NNP cord-016652-x8t3lf1x 272 16 capsid capsid NN cord-016652-x8t3lf1x 272 17 formation formation NN cord-016652-x8t3lf1x 272 18 in in IN cord-016652-x8t3lf1x 272 19 the the DT cord-016652-x8t3lf1x 272 20 nucleolus nucleolus NN cord-016652-x8t3lf1x 272 21 Role role NN cord-016652-x8t3lf1x 272 22 of of IN cord-016652-x8t3lf1x 272 23 phosphorylation phosphorylation NN cord-016652-x8t3lf1x 272 24 clusters cluster NNS cord-016652-x8t3lf1x 272 25 in in IN cord-016652-x8t3lf1x 272 26 the the DT cord-016652-x8t3lf1x 272 27 biology biology NN cord-016652-x8t3lf1x 272 28 of of IN cord-016652-x8t3lf1x 272 29 the the DT cord-016652-x8t3lf1x 272 30 coronavirus coronavirus NN cord-016652-x8t3lf1x 272 31 infectious infectious JJ cord-016652-x8t3lf1x 272 32 bronchitis bronchitis NN cord-016652-x8t3lf1x 272 33 virus virus NN cord-016652-x8t3lf1x 272 34 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 272 35 protein protein NN cord-016652-x8t3lf1x 272 36 Upstream Upstream NNP cord-016652-x8t3lf1x 272 37 - - HYPH cord-016652-x8t3lf1x 272 38 binding bind VBG cord-016652-x8t3lf1x 272 39 factor factor NN cord-016652-x8t3lf1x 272 40 is be VBZ cord-016652-x8t3lf1x 272 41 sequestered sequester VBN cord-016652-x8t3lf1x 272 42 into into IN cord-016652-x8t3lf1x 272 43 herpes herpes NN cord-016652-x8t3lf1x 272 44 simplex simplex NNP cord-016652-x8t3lf1x 272 45 virus virus NN cord-016652-x8t3lf1x 272 46 type type NN cord-016652-x8t3lf1x 272 47 1 1 CD cord-016652-x8t3lf1x 272 48 replication replication NN cord-016652-x8t3lf1x 272 49 compartments compartment NNS cord-016652-x8t3lf1x 272 50 Nucleolin Nucleolin NNP cord-016652-x8t3lf1x 272 51 associates associate NNS cord-016652-x8t3lf1x 272 52 with with IN cord-016652-x8t3lf1x 272 53 the the DT cord-016652-x8t3lf1x 272 54 human human JJ cord-016652-x8t3lf1x 272 55 cytomegalovirus cytomegalovirus NN cord-016652-x8t3lf1x 272 56 DNA dna NN cord-016652-x8t3lf1x 272 57 polymerase polymerase NN cord-016652-x8t3lf1x 272 58 accessory accessory NN cord-016652-x8t3lf1x 272 59 subunit subunit NN cord-016652-x8t3lf1x 272 60 UL44 UL44 NNP cord-016652-x8t3lf1x 272 61 and and CC cord-016652-x8t3lf1x 272 62 is be VBZ cord-016652-x8t3lf1x 272 63 necessary necessary JJ cord-016652-x8t3lf1x 272 64 for for IN cord-016652-x8t3lf1x 272 65 efficient efficient JJ cord-016652-x8t3lf1x 272 66 viral viral JJ cord-016652-x8t3lf1x 272 67 replication replication NN cord-016652-x8t3lf1x 272 68 Reversible reversible JJ cord-016652-x8t3lf1x 272 69 nucleolar nucleolar JJ cord-016652-x8t3lf1x 272 70 translocation translocation NN cord-016652-x8t3lf1x 272 71 of of IN cord-016652-x8t3lf1x 272 72 Epstein Epstein NNP cord-016652-x8t3lf1x 272 73 - - HYPH cord-016652-x8t3lf1x 272 74 Barr Barr NNP cord-016652-x8t3lf1x 272 75 virus virus NN cord-016652-x8t3lf1x 272 76 - - HYPH cord-016652-x8t3lf1x 272 77 encoded encode VBN cord-016652-x8t3lf1x 272 78 EBNA-5 EBNA-5 NNS cord-016652-x8t3lf1x 272 79 and and CC cord-016652-x8t3lf1x 272 80 hsp70 hsp70 NN cord-016652-x8t3lf1x 272 81 proteins protein NNS cord-016652-x8t3lf1x 272 82 after after IN cord-016652-x8t3lf1x 272 83 exposure exposure NN cord-016652-x8t3lf1x 272 84 to to IN cord-016652-x8t3lf1x 272 85 heat heat NN cord-016652-x8t3lf1x 272 86 shock shock NN cord-016652-x8t3lf1x 272 87 or or CC cord-016652-x8t3lf1x 272 88 cell cell NN cord-016652-x8t3lf1x 272 89 density density NN cord-016652-x8t3lf1x 272 90 congestion congestion NN cord-016652-x8t3lf1x 272 91 Birth birth NN cord-016652-x8t3lf1x 272 92 of of IN cord-016652-x8t3lf1x 272 93 a a DT cord-016652-x8t3lf1x 272 94 nucleolus nucleolus NN cord-016652-x8t3lf1x 272 95 : : : cord-016652-x8t3lf1x 272 96 the the DT cord-016652-x8t3lf1x 272 97 evolution evolution NN cord-016652-x8t3lf1x 272 98 of of IN cord-016652-x8t3lf1x 272 99 nucleolar nucleolar JJ cord-016652-x8t3lf1x 272 100 compartments compartment NNS cord-016652-x8t3lf1x 272 101 Nuclear nuclear JJ cord-016652-x8t3lf1x 272 102 localization localization NN cord-016652-x8t3lf1x 272 103 of of IN cord-016652-x8t3lf1x 272 104 non non JJ cord-016652-x8t3lf1x 272 105 - - JJ cord-016652-x8t3lf1x 272 106 structural structural JJ cord-016652-x8t3lf1x 272 107 protein protein NN cord-016652-x8t3lf1x 272 108 1 1 CD cord-016652-x8t3lf1x 272 109 and and CC cord-016652-x8t3lf1x 272 110 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 272 111 protein protein NN cord-016652-x8t3lf1x 272 112 of of IN cord-016652-x8t3lf1x 272 113 equine equine JJ cord-016652-x8t3lf1x 272 114 arteritis arteritis NN cord-016652-x8t3lf1x 272 115 virus virus NN cord-016652-x8t3lf1x 272 116 Identification identification NN cord-016652-x8t3lf1x 272 117 of of IN cord-016652-x8t3lf1x 272 118 a a DT cord-016652-x8t3lf1x 272 119 new new JJ cord-016652-x8t3lf1x 272 120 human human JJ cord-016652-x8t3lf1x 272 121 adenovirus adenovirus NN cord-016652-x8t3lf1x 272 122 protein protein NN cord-016652-x8t3lf1x 272 123 encoded encode VBN cord-016652-x8t3lf1x 272 124 by by IN cord-016652-x8t3lf1x 272 125 a a DT cord-016652-x8t3lf1x 272 126 novel novel NN cord-016652-x8t3lf1x 272 127 late late JJ cord-016652-x8t3lf1x 272 128 l l NN cord-016652-x8t3lf1x 272 129 - - HYPH cord-016652-x8t3lf1x 272 130 strand strand NN cord-016652-x8t3lf1x 272 131 transcription transcription NN cord-016652-x8t3lf1x 272 132 unit unit NN cord-016652-x8t3lf1x 272 133 Identifying identify VBG cord-016652-x8t3lf1x 272 134 specific specific JJ cord-016652-x8t3lf1x 272 135 protein protein NN cord-016652-x8t3lf1x 272 136 interaction interaction NN cord-016652-x8t3lf1x 272 137 partners partner NNS cord-016652-x8t3lf1x 272 138 using use VBG cord-016652-x8t3lf1x 272 139 quantitative quantitative JJ cord-016652-x8t3lf1x 272 140 mass mass NN cord-016652-x8t3lf1x 272 141 spectrometry spectrometry NN cord-016652-x8t3lf1x 272 142 and and CC cord-016652-x8t3lf1x 272 143 bead bead NN cord-016652-x8t3lf1x 272 144 proteomes proteome NNS cord-016652-x8t3lf1x 272 145 Complete Complete NNP cord-016652-x8t3lf1x 272 146 genome genome NN cord-016652-x8t3lf1x 272 147 sequence sequence NN cord-016652-x8t3lf1x 272 148 and and CC cord-016652-x8t3lf1x 272 149 in in IN cord-016652-x8t3lf1x 272 150 planta planta NN cord-016652-x8t3lf1x 272 151 subcellular subcellular JJ cord-016652-x8t3lf1x 272 152 localization localization NN cord-016652-x8t3lf1x 272 153 of of IN cord-016652-x8t3lf1x 272 154 maize maize NN cord-016652-x8t3lf1x 272 155 fine fine JJ cord-016652-x8t3lf1x 272 156 streak streak NN cord-016652-x8t3lf1x 272 157 virus virus NN cord-016652-x8t3lf1x 272 158 proteins protein NNS cord-016652-x8t3lf1x 273 1 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 273 2 protein protein NN cord-016652-x8t3lf1x 274 1 B23 B23 NNP cord-016652-x8t3lf1x 274 2 interacts interact VBZ cord-016652-x8t3lf1x 274 3 with with IN cord-016652-x8t3lf1x 274 4 Japanese japanese JJ cord-016652-x8t3lf1x 274 5 encephalitis encephalitis JJ cord-016652-x8t3lf1x 274 6 virus virus NN cord-016652-x8t3lf1x 274 7 core core NN cord-016652-x8t3lf1x 274 8 protein protein NN cord-016652-x8t3lf1x 274 9 and and CC cord-016652-x8t3lf1x 274 10 participates participate VBZ cord-016652-x8t3lf1x 274 11 in in IN cord-016652-x8t3lf1x 274 12 viral viral JJ cord-016652-x8t3lf1x 274 13 replication replication NN cord-016652-x8t3lf1x 274 14 Nuclear nuclear JJ cord-016652-x8t3lf1x 274 15 localization localization NN cord-016652-x8t3lf1x 274 16 of of IN cord-016652-x8t3lf1x 274 17 flavivirus flavivirus NNP cord-016652-x8t3lf1x 274 18 RNA RNA NNP cord-016652-x8t3lf1x 274 19 synthesis synthesis NN cord-016652-x8t3lf1x 274 20 in in IN cord-016652-x8t3lf1x 274 21 infected infected JJ cord-016652-x8t3lf1x 274 22 cells cell NNS cord-016652-x8t3lf1x 274 23 Relocalization Relocalization NNP cord-016652-x8t3lf1x 274 24 of of IN cord-016652-x8t3lf1x 274 25 nuclear nuclear JJ cord-016652-x8t3lf1x 274 26 ALY ALY NNP cord-016652-x8t3lf1x 274 27 proteins protein NNS cord-016652-x8t3lf1x 274 28 to to IN cord-016652-x8t3lf1x 274 29 the the DT cord-016652-x8t3lf1x 274 30 cytoplasm cytoplasm NN cord-016652-x8t3lf1x 274 31 by by IN cord-016652-x8t3lf1x 274 32 the the DT cord-016652-x8t3lf1x 274 33 tomato tomato NN cord-016652-x8t3lf1x 274 34 bushy bushy JJ cord-016652-x8t3lf1x 274 35 stunt stunt NN cord-016652-x8t3lf1x 274 36 virus virus NN cord-016652-x8t3lf1x 274 37 P19 p19 NN cord-016652-x8t3lf1x 274 38 pathogenicity pathogenicity NN cord-016652-x8t3lf1x 274 39 protein protein NN cord-016652-x8t3lf1x 274 40 Use Use NNP cord-016652-x8t3lf1x 274 41 of of IN cord-016652-x8t3lf1x 274 42 a a DT cord-016652-x8t3lf1x 274 43 U16 U16 NNP cord-016652-x8t3lf1x 274 44 snoRNA snorna NN cord-016652-x8t3lf1x 274 45 - - HYPH cord-016652-x8t3lf1x 274 46 containing contain VBG cord-016652-x8t3lf1x 274 47 ribozyme ribozyme NNP cord-016652-x8t3lf1x 274 48 library library NN cord-016652-x8t3lf1x 274 49 to to TO cord-016652-x8t3lf1x 274 50 identify identify VB cord-016652-x8t3lf1x 274 51 ribozyme ribozyme NN cord-016652-x8t3lf1x 274 52 targets target NNS cord-016652-x8t3lf1x 274 53 in in IN cord-016652-x8t3lf1x 274 54 HIV-1 HIV-1 NNP cord-016652-x8t3lf1x 274 55 Avian Avian NNP cord-016652-x8t3lf1x 274 56 reovirus reovirus NN cord-016652-x8t3lf1x 274 57 sigmaA sigmaA NNP cord-016652-x8t3lf1x 275 1 localizes localize VBZ cord-016652-x8t3lf1x 275 2 to to IN cord-016652-x8t3lf1x 275 3 the the DT cord-016652-x8t3lf1x 275 4 nucleolus nucleolus NN cord-016652-x8t3lf1x 275 5 and and CC cord-016652-x8t3lf1x 275 6 enters enter VBZ cord-016652-x8t3lf1x 275 7 the the DT cord-016652-x8t3lf1x 275 8 nucleus nucleus NN cord-016652-x8t3lf1x 275 9 by by IN cord-016652-x8t3lf1x 275 10 a a DT cord-016652-x8t3lf1x 275 11 nonclassical nonclassical JJ cord-016652-x8t3lf1x 275 12 energy energy NN cord-016652-x8t3lf1x 275 13 - - HYPH cord-016652-x8t3lf1x 275 14 and and CC cord-016652-x8t3lf1x 275 15 carrier carrier NN cord-016652-x8t3lf1x 275 16 - - HYPH cord-016652-x8t3lf1x 275 17 independent independent JJ cord-016652-x8t3lf1x 275 18 pathway pathway NN cord-016652-x8t3lf1x 275 19 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 275 20 localization localization NN cord-016652-x8t3lf1x 275 21 of of IN cord-016652-x8t3lf1x 275 22 influenza influenza NN cord-016652-x8t3lf1x 275 23 A a NN cord-016652-x8t3lf1x 275 24 NS1 ns1 NN cord-016652-x8t3lf1x 275 25 : : : cord-016652-x8t3lf1x 276 1 striking striking JJ cord-016652-x8t3lf1x 276 2 differences difference NNS cord-016652-x8t3lf1x 276 3 between between IN cord-016652-x8t3lf1x 276 4 mammalian mammalian JJ cord-016652-x8t3lf1x 276 5 and and CC cord-016652-x8t3lf1x 276 6 avian avian JJ cord-016652-x8t3lf1x 276 7 cells cell NNS cord-016652-x8t3lf1x 276 8 Viral viral JJ cord-016652-x8t3lf1x 276 9 ribonucleoprotein ribonucleoprotein NN cord-016652-x8t3lf1x 276 10 complex complex JJ cord-016652-x8t3lf1x 276 11 formation formation NN cord-016652-x8t3lf1x 276 12 and and CC cord-016652-x8t3lf1x 276 13 nucleolarcytoplasmic nucleolarcytoplasmic NNP cord-016652-x8t3lf1x 276 14 relocalization relocalization NNP cord-016652-x8t3lf1x 276 15 of of IN cord-016652-x8t3lf1x 276 16 nucleolin nucleolin NNP cord-016652-x8t3lf1x 276 17 in in IN cord-016652-x8t3lf1x 276 18 poliovirus poliovirus NN cord-016652-x8t3lf1x 276 19 - - HYPH cord-016652-x8t3lf1x 276 20 infected infect VBN cord-016652-x8t3lf1x 276 21 cells cell NNS cord-016652-x8t3lf1x 276 22 Interactions interaction NNS cord-016652-x8t3lf1x 276 23 of of IN cord-016652-x8t3lf1x 276 24 minute minute NN cord-016652-x8t3lf1x 276 25 virus virus NN cord-016652-x8t3lf1x 276 26 of of IN cord-016652-x8t3lf1x 276 27 mice mouse NNS cord-016652-x8t3lf1x 276 28 and and CC cord-016652-x8t3lf1x 276 29 adenovirus adenovirus NN cord-016652-x8t3lf1x 276 30 with with IN cord-016652-x8t3lf1x 276 31 host host NN cord-016652-x8t3lf1x 276 32 nucleoli nucleoli NNP cord-016652-x8t3lf1x 276 33 Intracellular Intracellular NNP cord-016652-x8t3lf1x 276 34 localization localization NN cord-016652-x8t3lf1x 276 35 and and CC cord-016652-x8t3lf1x 276 36 determination determination NN cord-016652-x8t3lf1x 276 37 of of IN cord-016652-x8t3lf1x 276 38 a a DT cord-016652-x8t3lf1x 276 39 nuclear nuclear JJ cord-016652-x8t3lf1x 276 40 localization localization NN cord-016652-x8t3lf1x 276 41 signal signal NN cord-016652-x8t3lf1x 276 42 of of IN cord-016652-x8t3lf1x 276 43 the the DT cord-016652-x8t3lf1x 276 44 core core NN cord-016652-x8t3lf1x 276 45 protein protein NN cord-016652-x8t3lf1x 276 46 of of IN cord-016652-x8t3lf1x 276 47 dengue dengue NN cord-016652-x8t3lf1x 276 48 virus virus NN cord-016652-x8t3lf1x 276 49 Proteins Proteins NNP cord-016652-x8t3lf1x 276 50 C C NNP cord-016652-x8t3lf1x 276 51 and and CC cord-016652-x8t3lf1x 276 52 NS4B NS4B NNP cord-016652-x8t3lf1x 276 53 of of IN cord-016652-x8t3lf1x 276 54 the the DT cord-016652-x8t3lf1x 276 55 flavivirus flavivirus JJ cord-016652-x8t3lf1x 276 56 Kunjin Kunjin NNP cord-016652-x8t3lf1x 276 57 translocate translocate VB cord-016652-x8t3lf1x 276 58 independently independently RB cord-016652-x8t3lf1x 276 59 into into IN cord-016652-x8t3lf1x 276 60 the the DT cord-016652-x8t3lf1x 276 61 nucleus nucleus NN cord-016652-x8t3lf1x 276 62 Subcellular Subcellular NNP cord-016652-x8t3lf1x 276 63 compartmentalization compartmentalization NN cord-016652-x8t3lf1x 276 64 of of IN cord-016652-x8t3lf1x 276 65 adeno adeno NN cord-016652-x8t3lf1x 276 66 - - HYPH cord-016652-x8t3lf1x 276 67 associated associate VBN cord-016652-x8t3lf1x 276 68 virus virus NN cord-016652-x8t3lf1x 276 69 type type NN cord-016652-x8t3lf1x 276 70 2 2 CD cord-016652-x8t3lf1x 276 71 assembly assembly NN cord-016652-x8t3lf1x 277 1 The the DT cord-016652-x8t3lf1x 277 2 N n CD cord-016652-x8t3lf1x 277 3 - - HYPH cord-016652-x8t3lf1x 277 4 terminal terminal NN cord-016652-x8t3lf1x 277 5 domain domain NN cord-016652-x8t3lf1x 277 6 of of IN cord-016652-x8t3lf1x 277 7 PMTV PMTV NNP cord-016652-x8t3lf1x 277 8 TGB1 TGB1 NNP cord-016652-x8t3lf1x 277 9 movement movement NN cord-016652-x8t3lf1x 277 10 protein protein NN cord-016652-x8t3lf1x 277 11 is be VBZ cord-016652-x8t3lf1x 277 12 required require VBN cord-016652-x8t3lf1x 277 13 for for IN cord-016652-x8t3lf1x 277 14 nucleolar nucleolar JJ cord-016652-x8t3lf1x 277 15 localization localization NN cord-016652-x8t3lf1x 277 16 , , , cord-016652-x8t3lf1x 277 17 microtubule microtubule NNP cord-016652-x8t3lf1x 277 18 association association NNP cord-016652-x8t3lf1x 277 19 , , , cord-016652-x8t3lf1x 277 20 and and CC cord-016652-x8t3lf1x 277 21 long long JJ cord-016652-x8t3lf1x 277 22 - - HYPH cord-016652-x8t3lf1x 277 23 distance distance NN cord-016652-x8t3lf1x 277 24 movement movement NN cord-016652-x8t3lf1x 277 25 Localisation Localisation NNP cord-016652-x8t3lf1x 277 26 to to IN cord-016652-x8t3lf1x 277 27 the the DT cord-016652-x8t3lf1x 277 28 nucleolus nucleolus NN cord-016652-x8t3lf1x 277 29 is be VBZ cord-016652-x8t3lf1x 277 30 a a DT cord-016652-x8t3lf1x 277 31 common common JJ cord-016652-x8t3lf1x 277 32 feature feature NN cord-016652-x8t3lf1x 277 33 of of IN cord-016652-x8t3lf1x 277 34 coronavirus coronavirus NN cord-016652-x8t3lf1x 277 35 nucleoproteins nucleoprotein NNS cord-016652-x8t3lf1x 277 36 and and CC cord-016652-x8t3lf1x 277 37 the the DT cord-016652-x8t3lf1x 277 38 protein protein NN cord-016652-x8t3lf1x 277 39 may may MD cord-016652-x8t3lf1x 277 40 disrupt disrupt VB cord-016652-x8t3lf1x 277 41 host host NN cord-016652-x8t3lf1x 277 42 cell cell NN cord-016652-x8t3lf1x 277 43 division division NN cord-016652-x8t3lf1x 277 44 Molecular molecular JJ cord-016652-x8t3lf1x 277 45 anatomy anatomy NN cord-016652-x8t3lf1x 277 46 of of IN cord-016652-x8t3lf1x 277 47 subcellular subcellular JJ cord-016652-x8t3lf1x 277 48 localization localization NN cord-016652-x8t3lf1x 277 49 of of IN cord-016652-x8t3lf1x 277 50 HSV-1 HSV-1 NNP cord-016652-x8t3lf1x 277 51 tegument tegument NN cord-016652-x8t3lf1x 277 52 protein protein NN cord-016652-x8t3lf1x 277 53 US11 US11 NNP cord-016652-x8t3lf1x 277 54 in in IN cord-016652-x8t3lf1x 277 55 living living NN cord-016652-x8t3lf1x 277 56 cells cell NNS cord-016652-x8t3lf1x 278 1 Nucleolar Nucleolar NNP cord-016652-x8t3lf1x 278 2 localization localization NN cord-016652-x8t3lf1x 278 3 of of IN cord-016652-x8t3lf1x 278 4 the the DT cord-016652-x8t3lf1x 278 5 UL3 ul3 JJ cord-016652-x8t3lf1x 278 6 protein protein NN cord-016652-x8t3lf1x 278 7 of of IN cord-016652-x8t3lf1x 278 8 herpes herpes NNP cord-016652-x8t3lf1x 278 9 simplex simplex NNP cord-016652-x8t3lf1x 278 10 virus virus NN cord-016652-x8t3lf1x 278 11 type type NN cord-016652-x8t3lf1x 278 12 2 2 CD cord-016652-x8t3lf1x 278 13 Colocalization Colocalization NNP cord-016652-x8t3lf1x 278 14 and and CC cord-016652-x8t3lf1x 278 15 interaction interaction NN cord-016652-x8t3lf1x 278 16 of of IN cord-016652-x8t3lf1x 278 17 the the DT cord-016652-x8t3lf1x 278 18 porcine porcine JJ cord-016652-x8t3lf1x 278 19 arterivirus arterivirus NNP cord-016652-x8t3lf1x 278 20 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 278 21 protein protein NNP cord-016652-x8t3lf1x 278 22 with with IN cord-016652-x8t3lf1x 278 23 the the DT cord-016652-x8t3lf1x 278 24 small small JJ cord-016652-x8t3lf1x 278 25 nucleolar nucleolar JJ cord-016652-x8t3lf1x 278 26 RNA RNA NNP cord-016652-x8t3lf1x 278 27 - - HYPH cord-016652-x8t3lf1x 278 28 associated associate VBN cord-016652-x8t3lf1x 278 29 protein protein NN cord-016652-x8t3lf1x 278 30 fibrillarin fibrillarin NNP cord-016652-x8t3lf1x 278 31 Subcellular Subcellular NNP cord-016652-x8t3lf1x 278 32 localization localization NN cord-016652-x8t3lf1x 278 33 of of IN cord-016652-x8t3lf1x 278 34 the the DT cord-016652-x8t3lf1x 278 35 severe severe JJ cord-016652-x8t3lf1x 278 36 acute acute JJ cord-016652-x8t3lf1x 278 37 respiratory respiratory JJ cord-016652-x8t3lf1x 278 38 syndrome syndrome NN cord-016652-x8t3lf1x 278 39 coronavirus coronavirus NN cord-016652-x8t3lf1x 278 40 nucleocapsid nucleocapsid NN cord-016652-x8t3lf1x 278 41 protein protein NNP cord-016652-x8t3lf1x 278 42 A a DT cord-016652-x8t3lf1x 278 43 model model NN cord-016652-x8t3lf1x 278 44 for for IN cord-016652-x8t3lf1x 278 45 the the DT cord-016652-x8t3lf1x 278 46 dynamic dynamic JJ cord-016652-x8t3lf1x 278 47 nuclear/ nuclear/ NN cord-016652-x8t3lf1x 278 48 nucleolar nucleolar JJ cord-016652-x8t3lf1x 278 49 / / SYM cord-016652-x8t3lf1x 278 50 cytoplasmic cytoplasmic JJ cord-016652-x8t3lf1x 278 51 trafficking trafficking NN cord-016652-x8t3lf1x 278 52 of of IN cord-016652-x8t3lf1x 278 53 the the DT cord-016652-x8t3lf1x 278 54 porcine porcine JJ cord-016652-x8t3lf1x 278 55 reproductive reproductive JJ cord-016652-x8t3lf1x 278 56 and and CC cord-016652-x8t3lf1x 278 57 respiratory respiratory JJ cord-016652-x8t3lf1x 278 58 syndrome syndrome NN cord-016652-x8t3lf1x 278 59 virus virus NN cord-016652-x8t3lf1x 278 60 ( ( -LRB- cord-016652-x8t3lf1x 278 61 PRRSV PRRSV NNP cord-016652-x8t3lf1x 278 62 ) ) -RRB- cord-016652-x8t3lf1x 278 63 nucleocapsid nucleocapsid NNP cord-016652-x8t3lf1x 278 64 protein protein NN cord-016652-x8t3lf1x 278 65 based base VBN cord-016652-x8t3lf1x 278 66 on on IN cord-016652-x8t3lf1x 278 67 live live JJ cord-016652-x8t3lf1x 278 68 cell cell NN cord-016652-x8t3lf1x 278 69 imaging imaging NN cord-016652-x8t3lf1x 278 70 G0 G0 NNP cord-016652-x8t3lf1x 278 71 / / SYM cord-016652-x8t3lf1x 278 72 G1 G1 NNP cord-016652-x8t3lf1x 278 73 arrest arrest NN cord-016652-x8t3lf1x 278 74 and and CC cord-016652-x8t3lf1x 278 75 apoptosis apoptosis NN cord-016652-x8t3lf1x 278 76 induced induce VBN cord-016652-x8t3lf1x 278 77 by by IN cord-016652-x8t3lf1x 278 78 SARS SARS NNP cord-016652-x8t3lf1x 278 79 - - HYPH cord-016652-x8t3lf1x 278 80 CoV CoV NNP cord-016652-x8t3lf1x 278 81 3b 3b NNP cord-016652-x8t3lf1x 278 82 protein protein NN cord-016652-x8t3lf1x 278 83 in in IN cord-016652-x8t3lf1x 278 84 transfected transfecte VBN cord-016652-x8t3lf1x 278 85 cells cell NNS cord-016652-x8t3lf1x 279 1 Intracellular Intracellular NNP cord-016652-x8t3lf1x 279 2 localization localization NN cord-016652-x8t3lf1x 279 3 of of IN cord-016652-x8t3lf1x 279 4 the the DT cord-016652-x8t3lf1x 279 5 UL31 UL31 NNP cord-016652-x8t3lf1x 279 6 protein protein NN cord-016652-x8t3lf1x 279 7 of of IN cord-016652-x8t3lf1x 279 8 herpes herpes NNP cord-016652-x8t3lf1x 279 9 simplex simplex NNP cord-016652-x8t3lf1x 279 10 virus virus NN cord-016652-x8t3lf1x 279 11 type type NN cord-016652-x8t3lf1x 279 12 2 2 CD cord-016652-x8t3lf1x 279 13 Acknowledgements Acknowledgements NNPS cord-016652-x8t3lf1x 279 14 DAM DAM NNP cord-016652-x8t3lf1x 279 15 and and CC cord-016652-x8t3lf1x 279 16 JAH JAH NNP cord-016652-x8t3lf1x 279 17 would would MD cord-016652-x8t3lf1x 279 18 like like VB cord-016652-x8t3lf1x 279 19 to to TO cord-016652-x8t3lf1x 279 20 acknowledge acknowledge VB cord-016652-x8t3lf1x 279 21 their -PRON- PRP$ cord-016652-x8t3lf1x 279 22 co co NNS cord-016652-x8t3lf1x 279 23 - - NNS cord-016652-x8t3lf1x 279 24 workers worker NNS cord-016652-x8t3lf1x 279 25 and and CC cord-016652-x8t3lf1x 279 26 collaborators collaborator NNS cord-016652-x8t3lf1x 279 27 over over IN cord-016652-x8t3lf1x 279 28 the the DT cord-016652-x8t3lf1x 279 29 years year NNS cord-016652-x8t3lf1x 279 30 for for IN cord-016652-x8t3lf1x 279 31 developing develop VBG cord-016652-x8t3lf1x 279 32 viral viral JJ cord-016652-x8t3lf1x 279 33 interactions interaction NNS cord-016652-x8t3lf1x 279 34 with with IN cord-016652-x8t3lf1x 279 35 the the DT cord-016652-x8t3lf1x 279 36 nucleolus nucleolus NN cord-016652-x8t3lf1x 279 37 . . . cord-016652-x8t3lf1x 280 1 DAM DAM NNP cord-016652-x8t3lf1x 280 2 's 's POS cord-016652-x8t3lf1x 280 3 research research NN cord-016652-x8t3lf1x 280 4 on on IN cord-016652-x8t3lf1x 280 5 the the DT cord-016652-x8t3lf1x 280 6 nucleolus nucleolus NN cord-016652-x8t3lf1x 280 7 is be VBZ cord-016652-x8t3lf1x 280 8 supported support VBN cord-016652-x8t3lf1x 280 9 by by IN cord-016652-x8t3lf1x 280 10 the the DT cord-016652-x8t3lf1x 280 11 Wellcome Wellcome NNP cord-016652-x8t3lf1x 280 12 Trust Trust NNP cord-016652-x8t3lf1x 280 13 and and CC cord-016652-x8t3lf1x 280 14 JAH JAH NNP cord-016652-x8t3lf1x 280 15 's 's POS cord-016652-x8t3lf1x 280 16 by by IN cord-016652-x8t3lf1x 280 17 the the DT cord-016652-x8t3lf1x 280 18 BBSRC BBSRC NNP cord-016652-x8t3lf1x 280 19 and and CC cord-016652-x8t3lf1x 280 20 a a DT cord-016652-x8t3lf1x 280 21 Leverhulme Leverhulme NNP cord-016652-x8t3lf1x 280 22 Trust Trust NNP cord-016652-x8t3lf1x 280 23 Research Research NNP cord-016652-x8t3lf1x 280 24 Fellowship Fellowship NNP cord-016652-x8t3lf1x 280 25 . . . cord-016652-x8t3lf1x 281 1 EE EE NNP cord-016652-x8t3lf1x 281 2 is be VBZ cord-016652-x8t3lf1x 281 3 supported support VBN cord-016652-x8t3lf1x 281 4 by by IN cord-016652-x8t3lf1x 281 5 a a DT cord-016652-x8t3lf1x 281 6 BBSRC BBSRC NNP cord-016652-x8t3lf1x 281 7 Astbury Astbury NNP cord-016652-x8t3lf1x 281 8 DTG DTG NNP cord-016652-x8t3lf1x 281 9 studentship studentship NN cord-016652-x8t3lf1x 281 10 . . .