id	sid	tid	token	lemma	pos
cord-276456-oa6hh7ky	1	1	key	key	NN
cord-276456-oa6hh7ky	1	2	:	:	:
cord-276456-oa6hh7ky	2	1	cord-276456-oa6hh7ky	cord-276456-oa6hh7ky	NNS
cord-276456-oa6hh7ky	3	1	authors	author	NNS
cord-276456-oa6hh7ky	3	2	:	:	:
cord-276456-oa6hh7ky	3	3	Collins	Collins	NNP
cord-276456-oa6hh7ky	3	4	,	,	,
cord-276456-oa6hh7ky	3	5	R.N.	R.N.	NNP
cord-276456-oa6hh7ky	3	6	;	;	:
cord-276456-oa6hh7ky	3	7	Holz	Holz	NNP
cord-276456-oa6hh7ky	3	8	,	,	,
cord-276456-oa6hh7ky	3	9	R.W.	R.W.	NNP
cord-276456-oa6hh7ky	3	10	;	;	:
cord-276456-oa6hh7ky	3	11	Zimmerberg	Zimmerberg	NNP
cord-276456-oa6hh7ky	3	12	,	,	,
cord-276456-oa6hh7ky	4	1	J.	J.	NNP
cord-276456-oa6hh7ky	4	2	title	title	NN
cord-276456-oa6hh7ky	4	3	:	:	:
cord-276456-oa6hh7ky	4	4	5.14	5.14	CD
cord-276456-oa6hh7ky	5	1	The	the	DT
cord-276456-oa6hh7ky	5	2	Biophysics	Biophysics	NNP
cord-276456-oa6hh7ky	5	3	of	of	IN
cord-276456-oa6hh7ky	5	4	Membrane	Membrane	NNP
cord-276456-oa6hh7ky	5	5	Fusion	Fusion	NNP
cord-276456-oa6hh7ky	5	6	date	date	NN
cord-276456-oa6hh7ky	5	7	:	:	:
cord-276456-oa6hh7ky	5	8	2012	2012	CD
cord-276456-oa6hh7ky	5	9	-	-	HYPH
cord-276456-oa6hh7ky	5	10	05	05	CD
cord-276456-oa6hh7ky	5	11	-	-	HYPH
cord-276456-oa6hh7ky	5	12	03	03	CD
cord-276456-oa6hh7ky	5	13	journal	journal	NN
cord-276456-oa6hh7ky	5	14	:	:	:
cord-276456-oa6hh7ky	6	1	Comprehensive	Comprehensive	NNP
cord-276456-oa6hh7ky	6	2	Biophysics	Biophysics	NNP
cord-276456-oa6hh7ky	6	3	DOI	DOI	NNP
cord-276456-oa6hh7ky	6	4	:	:	:
cord-276456-oa6hh7ky	6	5	10.1016	10.1016	CD
cord-276456-oa6hh7ky	6	6	/	/	SYM
cord-276456-oa6hh7ky	6	7	b978	b978	NN
cord-276456-oa6hh7ky	6	8	-	-	HYPH
cord-276456-oa6hh7ky	6	9	0	0	CD
cord-276456-oa6hh7ky	6	10	-	-	HYPH
cord-276456-oa6hh7ky	6	11	12	12	CD
cord-276456-oa6hh7ky	6	12	-	-	HYPH
cord-276456-oa6hh7ky	6	13	374920	374920	CD
cord-276456-oa6hh7ky	6	14	-	-	HYPH
cord-276456-oa6hh7ky	6	15	8.00523	8.00523	CD
cord-276456-oa6hh7ky	6	16	-	-	SYM
cord-276456-oa6hh7ky	6	17	3	3	CD
cord-276456-oa6hh7ky	6	18	sha	sha	NN
cord-276456-oa6hh7ky	6	19	:	:	:
cord-276456-oa6hh7ky	7	1	09c47c9967e0c584c5a003d1ba3a4258a9fcaf31	09c47c9967e0c584c5a003d1ba3a4258a9fcaf31	LS
cord-276456-oa6hh7ky	7	2	doc_id	doc_id	CD
cord-276456-oa6hh7ky	7	3	:	:	:
cord-276456-oa6hh7ky	7	4	276456	276456	CD
cord-276456-oa6hh7ky	7	5	cord_uid	cord_uid	NNS
cord-276456-oa6hh7ky	7	6	:	:	:
cord-276456-oa6hh7ky	8	1	oa6hh7ky	oa6hh7ky	NN
cord-276456-oa6hh7ky	9	1	A	a	DT
cord-276456-oa6hh7ky	9	2	crucial	crucial	JJ
cord-276456-oa6hh7ky	9	3	interplay	interplay	NN
cord-276456-oa6hh7ky	9	4	between	between	IN
cord-276456-oa6hh7ky	9	5	protein	protein	NN
cord-276456-oa6hh7ky	9	6	conformations	conformation	NNS
cord-276456-oa6hh7ky	9	7	and	and	CC
cord-276456-oa6hh7ky	9	8	lipid	lipid	NN
cord-276456-oa6hh7ky	9	9	membrane	membrane	NN
cord-276456-oa6hh7ky	9	10	energetics	energetic	NNS
cord-276456-oa6hh7ky	9	11	emerges	emerge	VBZ
cord-276456-oa6hh7ky	9	12	as	as	IN
cord-276456-oa6hh7ky	9	13	the	the	DT
cord-276456-oa6hh7ky	9	14	guiding	guide	VBG
cord-276456-oa6hh7ky	9	15	principle	principle	NN
cord-276456-oa6hh7ky	9	16	for	for	IN
cord-276456-oa6hh7ky	9	17	the	the	DT
cord-276456-oa6hh7ky	9	18	regulation	regulation	NN
cord-276456-oa6hh7ky	9	19	and	and	CC
cord-276456-oa6hh7ky	9	20	mechanism	mechanism	NN
cord-276456-oa6hh7ky	9	21	of	of	IN
cord-276456-oa6hh7ky	9	22	membrane	membrane	NN
cord-276456-oa6hh7ky	9	23	fusion	fusion	NN
cord-276456-oa6hh7ky	9	24	in	in	IN
cord-276456-oa6hh7ky	9	25	biological	biological	JJ
cord-276456-oa6hh7ky	9	26	systems	system	NNS
cord-276456-oa6hh7ky	9	27	.	.	.
cord-276456-oa6hh7ky	10	1	As	as	IN
cord-276456-oa6hh7ky	10	2	some	some	DT
cord-276456-oa6hh7ky	10	3	of	of	IN
cord-276456-oa6hh7ky	10	4	the	the	DT
cord-276456-oa6hh7ky	10	5	basics	basic	NNS
cord-276456-oa6hh7ky	10	6	of	of	IN
cord-276456-oa6hh7ky	10	7	fusion	fusion	NN
cord-276456-oa6hh7ky	10	8	become	become	VBN
cord-276456-oa6hh7ky	10	9	clear	clear	JJ
cord-276456-oa6hh7ky	10	10	,	,	,
cord-276456-oa6hh7ky	10	11	a	a	DT
cord-276456-oa6hh7ky	10	12	myriad	myriad	NN
cord-276456-oa6hh7ky	10	13	of	of	IN
cord-276456-oa6hh7ky	10	14	compelling	compelling	JJ
cord-276456-oa6hh7ky	10	15	questions	question	NNS
cord-276456-oa6hh7ky	10	16	come	come	VBP
cord-276456-oa6hh7ky	10	17	to	to	IN
cord-276456-oa6hh7ky	10	18	the	the	DT
cord-276456-oa6hh7ky	10	19	fore	fore	NN
cord-276456-oa6hh7ky	10	20	.	.	.
cord-276456-oa6hh7ky	11	1	Is	be	VBZ
cord-276456-oa6hh7ky	11	2	the	the	DT
cord-276456-oa6hh7ky	11	3	interior	interior	NN
cord-276456-oa6hh7ky	11	4	of	of	IN
cord-276456-oa6hh7ky	11	5	the	the	DT
cord-276456-oa6hh7ky	11	6	fusion	fusion	NN
cord-276456-oa6hh7ky	11	7	pore	pore	NN
cord-276456-oa6hh7ky	11	8	protein	protein	NN
cord-276456-oa6hh7ky	11	9	or	or	CC
cord-276456-oa6hh7ky	11	10	lipid	lipid	NN
cord-276456-oa6hh7ky	11	11	?	?	.
cord-276456-oa6hh7ky	12	1	Why	why	WRB
cord-276456-oa6hh7ky	12	2	is	be	VBZ
cord-276456-oa6hh7ky	12	3	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	12	4	release	release	NN
cord-276456-oa6hh7ky	12	5	so	so	RB
cord-276456-oa6hh7ky	12	6	fast	fast	RB
cord-276456-oa6hh7ky	12	7	?	?	.
cord-276456-oa6hh7ky	13	1	Why	why	WRB
cord-276456-oa6hh7ky	13	2	is	be	VBZ
cord-276456-oa6hh7ky	13	3	PIP(2	PIP(2	.
cord-276456-oa6hh7ky	13	4	)	)	-RRB-
cord-276456-oa6hh7ky	13	5	needed	need	VBN
cord-276456-oa6hh7ky	13	6	for	for	IN
cord-276456-oa6hh7ky	13	7	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	13	8	?	?	.
cord-276456-oa6hh7ky	14	1	How	how	WRB
cord-276456-oa6hh7ky	14	2	does	do	VBZ
cord-276456-oa6hh7ky	14	3	fusion	fusion	NN
cord-276456-oa6hh7ky	14	4	peptide	peptide	JJ
cord-276456-oa6hh7ky	14	5	insertion	insertion	NN
cord-276456-oa6hh7ky	14	6	lead	lead	NN
cord-276456-oa6hh7ky	14	7	to	to	IN
cord-276456-oa6hh7ky	14	8	fusion	fusion	NN
cord-276456-oa6hh7ky	14	9	of	of	IN
cord-276456-oa6hh7ky	14	10	viruses	virus	NNS
cord-276456-oa6hh7ky	14	11	to	to	IN
cord-276456-oa6hh7ky	14	12	cell	cell	NN
cord-276456-oa6hh7ky	14	13	membranes	membrane	NNS
cord-276456-oa6hh7ky	14	14	?	?	.
cord-276456-oa6hh7ky	15	1	What	what	WDT
cord-276456-oa6hh7ky	15	2	role	role	NN
cord-276456-oa6hh7ky	15	3	does	do	VBZ
cord-276456-oa6hh7ky	15	4	the	the	DT
cord-276456-oa6hh7ky	15	5	TMD	TMD	NNP
cord-276456-oa6hh7ky	15	6	play	play	VB
cord-276456-oa6hh7ky	15	7	?	?	.
cord-276456-oa6hh7ky	16	1	How	how	WRB
cord-276456-oa6hh7ky	16	2	can	can	MD
cord-276456-oa6hh7ky	16	3	studies	study	NNS
cord-276456-oa6hh7ky	16	4	on	on	IN
cord-276456-oa6hh7ky	16	5	membrane	membrane	NN
cord-276456-oa6hh7ky	16	6	fission	fission	NN
cord-276456-oa6hh7ky	16	7	contribute	contribute	VBP
cord-276456-oa6hh7ky	16	8	to	to	IN
cord-276456-oa6hh7ky	16	9	our	-PRON-	PRP$
cord-276456-oa6hh7ky	16	10	understanding	understanding	NN
cord-276456-oa6hh7ky	16	11	of	of	IN
cord-276456-oa6hh7ky	16	12	membrane	membrane	NN
cord-276456-oa6hh7ky	16	13	fusion	fusion	NN
cord-276456-oa6hh7ky	16	14	?	?	.
cord-276456-oa6hh7ky	17	1	What	what	WP
cord-276456-oa6hh7ky	17	2	exactly	exactly	RB
cord-276456-oa6hh7ky	17	3	are	be	VBP
cord-276456-oa6hh7ky	17	4	SNARE	snare	NN
cord-276456-oa6hh7ky	17	5	proteins	protein	NNS
cord-276456-oa6hh7ky	17	6	doing	do	VBG
cord-276456-oa6hh7ky	17	7	?	?	.
cord-276456-oa6hh7ky	18	1	The	the	DT
cord-276456-oa6hh7ky	18	2	biological	biological	JJ
cord-276456-oa6hh7ky	18	3	membrane	membrane	NN
cord-276456-oa6hh7ky	18	4	is	be	VBZ
cord-276456-oa6hh7ky	18	5	ancient	ancient	JJ
cord-276456-oa6hh7ky	18	6	,	,	,
cord-276456-oa6hh7ky	18	7	and	and	CC
cord-276456-oa6hh7ky	18	8	crucial	crucial	JJ
cord-276456-oa6hh7ky	18	9	to	to	IN
cord-276456-oa6hh7ky	18	10	the	the	DT
cord-276456-oa6hh7ky	18	11	emergence	emergence	NN
cord-276456-oa6hh7ky	18	12	of	of	IN
cord-276456-oa6hh7ky	18	13	life	life	NN
cord-276456-oa6hh7ky	18	14	itself	-PRON-	PRP
cord-276456-oa6hh7ky	18	15	.	.	.
cord-276456-oa6hh7ky	19	1	While	while	IN
cord-276456-oa6hh7ky	19	2	a	a	DT
cord-276456-oa6hh7ky	19	3	single	single	JJ
cord-276456-oa6hh7ky	19	4	topology	topology	NN
cord-276456-oa6hh7ky	19	5	of	of	IN
cord-276456-oa6hh7ky	19	6	membrane	membrane	NN
cord-276456-oa6hh7ky	19	7	was	be	VBD
cord-276456-oa6hh7ky	19	8	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	19	9	for	for	IN
cord-276456-oa6hh7ky	19	10	bacteria	bacteria	NNS
cord-276456-oa6hh7ky	19	11	and	and	CC
cord-276456-oa6hh7ky	19	12	archebacteria	archebacteria	NN
cord-276456-oa6hh7ky	19	13	,	,	,
cord-276456-oa6hh7ky	19	14	eukaryotic	eukaryotic	JJ
cord-276456-oa6hh7ky	19	15	cells	cell	NNS
cord-276456-oa6hh7ky	19	16	contain	contain	VBP
cord-276456-oa6hh7ky	19	17	specialized	specialized	JJ
cord-276456-oa6hh7ky	19	18	subcellular	subcellular	JJ
cord-276456-oa6hh7ky	19	19	systems	system	NNS
cord-276456-oa6hh7ky	19	20	of	of	IN
cord-276456-oa6hh7ky	19	21	more	more	JJR
cord-276456-oa6hh7ky	19	22	topologies	topology	NNS
cord-276456-oa6hh7ky	19	23	,	,	,
cord-276456-oa6hh7ky	19	24	enclosing	enclose	VBG
cord-276456-oa6hh7ky	19	25	many	many	JJ
cord-276456-oa6hh7ky	19	26	discontinuous	discontinuous	JJ
cord-276456-oa6hh7ky	19	27	volumes	volume	NNS
cord-276456-oa6hh7ky	19	28	.	.	.
cord-276456-oa6hh7ky	20	1	In	in	IN
cord-276456-oa6hh7ky	20	2	order	order	NN
cord-276456-oa6hh7ky	20	3	to	to	TO
cord-276456-oa6hh7ky	20	4	mix	mix	VB
cord-276456-oa6hh7ky	20	5	these	these	DT
cord-276456-oa6hh7ky	20	6	intracellular	intracellular	JJ
cord-276456-oa6hh7ky	20	7	volumes	volume	NNS
cord-276456-oa6hh7ky	20	8	,	,	,
cord-276456-oa6hh7ky	20	9	and	and	CC
cord-276456-oa6hh7ky	20	10	to	to	TO
cord-276456-oa6hh7ky	20	11	secrete	secrete	VB
cord-276456-oa6hh7ky	20	12	such	such	JJ
cord-276456-oa6hh7ky	20	13	volumes	volume	NNS
cord-276456-oa6hh7ky	20	14	to	to	IN
cord-276456-oa6hh7ky	20	15	the	the	DT
cord-276456-oa6hh7ky	20	16	extracellular	extracellular	JJ
cord-276456-oa6hh7ky	20	17	space	space	NN
cord-276456-oa6hh7ky	20	18	,	,	,
cord-276456-oa6hh7ky	20	19	or	or	CC
cord-276456-oa6hh7ky	20	20	to	to	TO
cord-276456-oa6hh7ky	20	21	add	add	VB
cord-276456-oa6hh7ky	20	22	a	a	DT
cord-276456-oa6hh7ky	20	23	volume	volume	NN
cord-276456-oa6hh7ky	20	24	to	to	IN
cord-276456-oa6hh7ky	20	25	the	the	DT
cord-276456-oa6hh7ky	20	26	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	20	27	space	space	NN
cord-276456-oa6hh7ky	20	28	,	,	,
cord-276456-oa6hh7ky	20	29	the	the	DT
cord-276456-oa6hh7ky	20	30	membranes	membrane	NNS
cord-276456-oa6hh7ky	20	31	enclosing	enclose	VBG
cord-276456-oa6hh7ky	20	32	one	one	CD
cord-276456-oa6hh7ky	20	33	of	of	IN
cord-276456-oa6hh7ky	20	34	these	these	DT
cord-276456-oa6hh7ky	20	35	volumes	volume	NNS
cord-276456-oa6hh7ky	20	36	must	must	MD
cord-276456-oa6hh7ky	20	37	either	either	CC
cord-276456-oa6hh7ky	20	38	rupture	rupture	VB
cord-276456-oa6hh7ky	20	39	or	or	CC
cord-276456-oa6hh7ky	20	40	merge	merge	VB
cord-276456-oa6hh7ky	20	41	with	with	IN
cord-276456-oa6hh7ky	20	42	another	another	DT
cord-276456-oa6hh7ky	20	43	membrane	membrane	NN
cord-276456-oa6hh7ky	20	44	,	,	,
cord-276456-oa6hh7ky	20	45	a	a	DT
cord-276456-oa6hh7ky	20	46	process	process	NN
cord-276456-oa6hh7ky	20	47	termed	term	VBN
cord-276456-oa6hh7ky	20	48	membrane	membrane	NN
cord-276456-oa6hh7ky	20	49	fusion	fusion	NN
cord-276456-oa6hh7ky	20	50	.	.	.
cord-276456-oa6hh7ky	21	1	Topological	topological	JJ
cord-276456-oa6hh7ky	21	2	membrane	membrane	NN
cord-276456-oa6hh7ky	21	3	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	21	4	,	,	,
cord-276456-oa6hh7ky	21	5	then	then	RB
cord-276456-oa6hh7ky	21	6	,	,	,
cord-276456-oa6hh7ky	21	7	such	such	JJ
cord-276456-oa6hh7ky	21	8	as	as	IN
cord-276456-oa6hh7ky	21	9	fusion	fusion	NN
cord-276456-oa6hh7ky	21	10	,	,	,
cord-276456-oa6hh7ky	21	11	its	-PRON-	PRP$
cord-276456-oa6hh7ky	21	12	inverse	inverse	NN
cord-276456-oa6hh7ky	21	13	-fission	-fission	NN
cord-276456-oa6hh7ky	21	14	,	,	,
cord-276456-oa6hh7ky	21	15	or	or	CC
cord-276456-oa6hh7ky	21	16	formation	formation	NN
cord-276456-oa6hh7ky	21	17	of	of	IN
cord-276456-oa6hh7ky	21	18	a	a	DT
cord-276456-oa6hh7ky	21	19	membrane	membrane	NN
cord-276456-oa6hh7ky	21	20	pore	pore	NN
cord-276456-oa6hh7ky	21	21	,	,	,
cord-276456-oa6hh7ky	21	22	are	be	VBP
cord-276456-oa6hh7ky	21	23	the	the	DT
cord-276456-oa6hh7ky	21	24	most	most	RBS
cord-276456-oa6hh7ky	21	25	essential	essential	JJ
cord-276456-oa6hh7ky	21	26	ingredients	ingredient	NNS
cord-276456-oa6hh7ky	21	27	of	of	IN
cord-276456-oa6hh7ky	21	28	the	the	DT
cord-276456-oa6hh7ky	21	29	complex	complex	JJ
cord-276456-oa6hh7ky	21	30	membrane	membrane	NN
cord-276456-oa6hh7ky	21	31	dynamics	dynamic	NNS
cord-276456-oa6hh7ky	21	32	of	of	IN
cord-276456-oa6hh7ky	21	33	living	living	NN
cord-276456-oa6hh7ky	21	34	cells	cell	NNS
cord-276456-oa6hh7ky	21	35	.	.	.
cord-276456-oa6hh7ky	22	1	These	these	DT
cord-276456-oa6hh7ky	22	2	membrane	membrane	NN
cord-276456-oa6hh7ky	22	3	transformations	transformation	NNS
cord-276456-oa6hh7ky	22	4	are	be	VBP
cord-276456-oa6hh7ky	22	5	key	key	JJ
cord-276456-oa6hh7ky	22	6	elements	element	NNS
cord-276456-oa6hh7ky	22	7	of	of	IN
cord-276456-oa6hh7ky	22	8	dynamic	dynamic	JJ
cord-276456-oa6hh7ky	22	9	intracellular	intracellular	JJ
cord-276456-oa6hh7ky	22	10	trafficking	trafficking	NN
cord-276456-oa6hh7ky	22	11	networks	network	NNS
cord-276456-oa6hh7ky	22	12	;	;	:
cord-276456-oa6hh7ky	22	13	they	-PRON-	PRP
cord-276456-oa6hh7ky	22	14	are	be	VBP
cord-276456-oa6hh7ky	22	15	also	also	RB
cord-276456-oa6hh7ky	22	16	intimately	intimately	RB
cord-276456-oa6hh7ky	22	17	linked	link	VBN
cord-276456-oa6hh7ky	22	18	to	to	IN
cord-276456-oa6hh7ky	22	19	important	important	JJ
cord-276456-oa6hh7ky	22	20	pathological	pathological	JJ
cord-276456-oa6hh7ky	22	21	processes	process	NNS
cord-276456-oa6hh7ky	22	22	including	include	VBG
cord-276456-oa6hh7ky	22	23	cellular	cellular	JJ
cord-276456-oa6hh7ky	22	24	entry	entry	NN
cord-276456-oa6hh7ky	22	25	and	and	CC
cord-276456-oa6hh7ky	22	26	egression	egression	NN
cord-276456-oa6hh7ky	22	27	of	of	IN
cord-276456-oa6hh7ky	22	28	enveloped	enveloped	JJ
cord-276456-oa6hh7ky	22	29	viruses	virus	NNS
cord-276456-oa6hh7ky	22	30	and	and	CC
cord-276456-oa6hh7ky	22	31	various	various	JJ
cord-276456-oa6hh7ky	22	32	parasites	parasite	NNS
cord-276456-oa6hh7ky	22	33	,	,	,
cord-276456-oa6hh7ky	22	34	membrane	membrane	NN
cord-276456-oa6hh7ky	22	35	rupture	rupture	NN
cord-276456-oa6hh7ky	22	36	and	and	CC
cord-276456-oa6hh7ky	22	37	apoptosis	apoptosis	NN
cord-276456-oa6hh7ky	22	38	.	.	.
cord-276456-oa6hh7ky	23	1	The	the	DT
cord-276456-oa6hh7ky	23	2	topological	topological	JJ
cord-276456-oa6hh7ky	23	3	membrane	membrane	NN
cord-276456-oa6hh7ky	23	4	remodeling	remodeling	NN
cord-276456-oa6hh7ky	23	5	generally	generally	RB
cord-276456-oa6hh7ky	23	6	converges	converge	VBZ
cord-276456-oa6hh7ky	23	7	to	to	IN
cord-276456-oa6hh7ky	23	8	highly	highly	RB
cord-276456-oa6hh7ky	23	9	bent	bent	JJ
cord-276456-oa6hh7ky	23	10	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	23	11	.	.	.
cord-276456-oa6hh7ky	24	1	The	the	DT
cord-276456-oa6hh7ky	24	2	characteristic	characteristic	JJ
cord-276456-oa6hh7ky	24	3	length	length	NN
cord-276456-oa6hh7ky	24	4	scales	scale	NNS
cord-276456-oa6hh7ky	24	5	associated	associate	VBN
cord-276456-oa6hh7ky	24	6	with	with	IN
cord-276456-oa6hh7ky	24	7	key	key	JJ
cord-276456-oa6hh7ky	24	8	structural	structural	JJ
cord-276456-oa6hh7ky	24	9	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	24	10	,	,	,
cord-276456-oa6hh7ky	24	11	such	such	JJ
cord-276456-oa6hh7ky	24	12	as	as	IN
cord-276456-oa6hh7ky	24	13	fusion	fusion	NN
cord-276456-oa6hh7ky	24	14	or	or	CC
cord-276456-oa6hh7ky	24	15	fission	fission	NN
cord-276456-oa6hh7ky	24	16	pores	pore	NNS
cord-276456-oa6hh7ky	24	17	,	,	,
cord-276456-oa6hh7ky	24	18	are	be	VBP
cord-276456-oa6hh7ky	24	19	typically	typically	RB
cord-276456-oa6hh7ky	24	20	of	of	IN
cord-276456-oa6hh7ky	24	21	the	the	DT
cord-276456-oa6hh7ky	24	22	order	order	NN
cord-276456-oa6hh7ky	24	23	of	of	IN
cord-276456-oa6hh7ky	24	24	tens	ten	NNS
cord-276456-oa6hh7ky	24	25	of	of	IN
cord-276456-oa6hh7ky	24	26	nanometers	nanometer	NNS
cord-276456-oa6hh7ky	24	27	.	.	.
cord-276456-oa6hh7ky	25	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	25	2	has	have	VBZ
cord-276456-oa6hh7ky	25	3	become	become	VBN
cord-276456-oa6hh7ky	25	4	increasingly	increasingly	RB
cord-276456-oa6hh7ky	25	5	clear	clear	JJ
cord-276456-oa6hh7ky	25	6	that	that	IN
cord-276456-oa6hh7ky	25	7	critical	critical	JJ
cord-276456-oa6hh7ky	25	8	properties	property	NNS
cord-276456-oa6hh7ky	25	9	of	of	IN
cord-276456-oa6hh7ky	25	10	biological	biological	JJ
cord-276456-oa6hh7ky	25	11	material	material	NN
cord-276456-oa6hh7ky	25	12	at	at	IN
cord-276456-oa6hh7ky	25	13	this	this	DT
cord-276456-oa6hh7ky	25	14	nanoscale	nanoscale	NN
cord-276456-oa6hh7ky	25	15	can	can	MD
cord-276456-oa6hh7ky	25	16	not	not	RB
cord-276456-oa6hh7ky	25	17	be	be	VB
cord-276456-oa6hh7ky	25	18	readily	readily	RB
cord-276456-oa6hh7ky	25	19	extrapolated	extrapolate	VBN
cord-276456-oa6hh7ky	25	20	from	from	IN
cord-276456-oa6hh7ky	25	21	bulk	bulk	JJ
cord-276456-oa6hh7ky	25	22	measurements	measurement	NNS
cord-276456-oa6hh7ky	25	23	.	.	.
cord-276456-oa6hh7ky	26	1	Neither	neither	DT
cord-276456-oa6hh7ky	26	2	can	can	MD
cord-276456-oa6hh7ky	26	3	they	-PRON-	PRP
cord-276456-oa6hh7ky	26	4	be	be	VB
cord-276456-oa6hh7ky	26	5	obtained	obtain	VBN
cord-276456-oa6hh7ky	26	6	from	from	IN
cord-276456-oa6hh7ky	26	7	experiments	experiment	NNS
cord-276456-oa6hh7ky	26	8	with	with	IN
cord-276456-oa6hh7ky	26	9	individual	individual	JJ
cord-276456-oa6hh7ky	26	10	molecules	molecule	NNS
cord-276456-oa6hh7ky	26	11	,	,	,
cord-276456-oa6hh7ky	26	12	as	as	IN
cord-276456-oa6hh7ky	26	13	in	in	IN
cord-276456-oa6hh7ky	26	14	many	many	JJ
cord-276456-oa6hh7ky	26	15	cases	case	NNS
cord-276456-oa6hh7ky	26	16	,	,	,
cord-276456-oa6hh7ky	26	17	especially	especially	RB
cord-276456-oa6hh7ky	26	18	in	in	IN
cord-276456-oa6hh7ky	26	19	most	most	JJS
cord-276456-oa6hh7ky	26	20	membrane	membrane	NN
cord-276456-oa6hh7ky	26	21	processes	process	NNS
cord-276456-oa6hh7ky	26	22	,	,	,
cord-276456-oa6hh7ky	26	23	the	the	DT
cord-276456-oa6hh7ky	26	24	functional	functional	JJ
cord-276456-oa6hh7ky	26	25	unit	unit	NN
cord-276456-oa6hh7ky	26	26	is	be	VBZ
cord-276456-oa6hh7ky	26	27	not	not	RB
cord-276456-oa6hh7ky	26	28	a	a	DT
cord-276456-oa6hh7ky	26	29	single	single	JJ
cord-276456-oa6hh7ky	26	30	protein	protein	NN
cord-276456-oa6hh7ky	26	31	(	(	-LRB-
cord-276456-oa6hh7ky	26	32	e.g.	e.g.	RB
cord-276456-oa6hh7ky	26	33	,	,	,
cord-276456-oa6hh7ky	26	34	channel	channel	NNP
cord-276456-oa6hh7ky	26	35	)	)	-RRB-
cord-276456-oa6hh7ky	26	36	,	,	,
cord-276456-oa6hh7ky	26	37	but	but	CC
cord-276456-oa6hh7ky	26	38	a	a	DT
cord-276456-oa6hh7ky	26	39	selectively	selectively	RB
cord-276456-oa6hh7ky	26	40	self	self	NN
cord-276456-oa6hh7ky	26	41	-	-	HYPH
cord-276456-oa6hh7ky	26	42	assembled	assemble	VBN
cord-276456-oa6hh7ky	26	43	cluster	cluster	NN
cord-276456-oa6hh7ky	26	44	of	of	IN
cord-276456-oa6hh7ky	26	45	proteins	protein	NNS
cord-276456-oa6hh7ky	26	46	and	and	CC
cord-276456-oa6hh7ky	26	47	lipids	lipid	NNS
cord-276456-oa6hh7ky	26	48	acting	act	VBG
cord-276456-oa6hh7ky	26	49	in	in	IN
cord-276456-oa6hh7ky	26	50	a	a	DT
cord-276456-oa6hh7ky	26	51	highly	highly	RB
cord-276456-oa6hh7ky	26	52	co	co	JJ
cord-276456-oa6hh7ky	26	53	-	-	JJ
cord-276456-oa6hh7ky	26	54	operative	operative	JJ
cord-276456-oa6hh7ky	26	55	manner	manner	NN
cord-276456-oa6hh7ky	26	56	.	.	.
cord-276456-oa6hh7ky	27	1	Therefore	therefore	RB
cord-276456-oa6hh7ky	27	2	,	,	,
cord-276456-oa6hh7ky	27	3	for	for	IN
cord-276456-oa6hh7ky	27	4	intuition	intuition	NN
cord-276456-oa6hh7ky	27	5	and	and	CC
cord-276456-oa6hh7ky	27	6	information	information	NN
cord-276456-oa6hh7ky	27	7	about	about	IN
cord-276456-oa6hh7ky	27	8	the	the	DT
cord-276456-oa6hh7ky	27	9	nature	nature	NN
cord-276456-oa6hh7ky	27	10	of	of	IN
cord-276456-oa6hh7ky	27	11	these	these	DT
cord-276456-oa6hh7ky	27	12	transformations	transformation	NNS
cord-276456-oa6hh7ky	27	13	,	,	,
cord-276456-oa6hh7ky	27	14	we	-PRON-	PRP
cord-276456-oa6hh7ky	27	15	must	must	MD
cord-276456-oa6hh7ky	27	16	create	create	VB
cord-276456-oa6hh7ky	27	17	and	and	CC
cord-276456-oa6hh7ky	27	18	study	study	VB
cord-276456-oa6hh7ky	27	19	them	-PRON-	PRP
cord-276456-oa6hh7ky	27	20	where	where	WRB
cord-276456-oa6hh7ky	27	21	possible	possible	JJ
cord-276456-oa6hh7ky	27	22	.	.	.
cord-276456-oa6hh7ky	28	1	Since	since	IN
cord-276456-oa6hh7ky	28	2	the	the	DT
cord-276456-oa6hh7ky	28	3	biological	biological	JJ
cord-276456-oa6hh7ky	28	4	membrane	membrane	NN
cord-276456-oa6hh7ky	28	5	is	be	VBZ
cord-276456-oa6hh7ky	28	6	thin	thin	JJ
cord-276456-oa6hh7ky	28	7	(	(	-LRB-
cord-276456-oa6hh7ky	28	8	5	5	CD
cord-276456-oa6hh7ky	28	9	nm	nm	NN
cord-276456-oa6hh7ky	28	10	in	in	IN
cord-276456-oa6hh7ky	28	11	thickness	thickness	NN
cord-276456-oa6hh7ky	28	12	,	,	,
cord-276456-oa6hh7ky	28	13	that	that	DT
cord-276456-oa6hh7ky	28	14	of	of	IN
cord-276456-oa6hh7ky	28	15	two	two	CD
cord-276456-oa6hh7ky	28	16	lipid	lipid	NN
cord-276456-oa6hh7ky	28	17	molecules	molecule	NNS
cord-276456-oa6hh7ky	28	18	)	)	-RRB-
cord-276456-oa6hh7ky	28	19	we	-PRON-	PRP
cord-276456-oa6hh7ky	28	20	can	can	MD
cord-276456-oa6hh7ky	28	21	not	not	RB
cord-276456-oa6hh7ky	28	22	see	see	VB
cord-276456-oa6hh7ky	28	23	the	the	DT
cord-276456-oa6hh7ky	28	24	process	process	NN
cord-276456-oa6hh7ky	28	25	of	of	IN
cord-276456-oa6hh7ky	28	26	membrane	membrane	NN
cord-276456-oa6hh7ky	28	27	fusion	fusion	NN
cord-276456-oa6hh7ky	28	28	under	under	IN
cord-276456-oa6hh7ky	28	29	the	the	DT
cord-276456-oa6hh7ky	28	30	microscope	microscope	NN
cord-276456-oa6hh7ky	28	31	;	;	:
cord-276456-oa6hh7ky	28	32	we	-PRON-	PRP
cord-276456-oa6hh7ky	28	33	can	can	MD
cord-276456-oa6hh7ky	28	34	only	only	RB
cord-276456-oa6hh7ky	28	35	see	see	VB
cord-276456-oa6hh7ky	28	36	the	the	DT
cord-276456-oa6hh7ky	28	37	sequellae	sequellae	NNS
cord-276456-oa6hh7ky	28	38	of	of	IN
cord-276456-oa6hh7ky	28	39	fusion	fusion	NN
cord-276456-oa6hh7ky	28	40	as	as	IN
cord-276456-oa6hh7ky	28	41	organellar	organellar	NNP
cord-276456-oa6hh7ky	28	42	or	or	CC
cord-276456-oa6hh7ky	28	43	cellular	cellular	JJ
cord-276456-oa6hh7ky	28	44	contents	content	NNS
cord-276456-oa6hh7ky	28	45	mix	mix	NN
cord-276456-oa6hh7ky	28	46	or	or	CC
cord-276456-oa6hh7ky	28	47	are	be	VBP
cord-276456-oa6hh7ky	28	48	secreted	secrete	VBN
cord-276456-oa6hh7ky	28	49	.	.	.
cord-276456-oa6hh7ky	29	1	The	the	DT
cord-276456-oa6hh7ky	29	2	simplest	simple	JJS
cord-276456-oa6hh7ky	29	3	natural	natural	JJ
cord-276456-oa6hh7ky	29	4	occurring	occur	VBG
cord-276456-oa6hh7ky	29	5	instance	instance	NN
cord-276456-oa6hh7ky	29	6	of	of	IN
cord-276456-oa6hh7ky	29	7	fusion	fusion	NN
cord-276456-oa6hh7ky	29	8	is	be	VBZ
cord-276456-oa6hh7ky	29	9	the	the	DT
cord-276456-oa6hh7ky	29	10	coalescence	coalescence	NN
cord-276456-oa6hh7ky	29	11	of	of	IN
cord-276456-oa6hh7ky	29	12	two	two	CD
cord-276456-oa6hh7ky	29	13	miscible	miscible	JJ
cord-276456-oa6hh7ky	29	14	liquid	liquid	JJ
cord-276456-oa6hh7ky	29	15	droplets	droplet	NNS
cord-276456-oa6hh7ky	29	16	in	in	IN
cord-276456-oa6hh7ky	29	17	air	air	NN
cord-276456-oa6hh7ky	29	18	,	,	,
cord-276456-oa6hh7ky	29	19	whose	whose	WP$
cord-276456-oa6hh7ky	29	20	two	two	CD
cord-276456-oa6hh7ky	29	21	outer	outer	JJ
cord-276456-oa6hh7ky	29	22	molecular	molecular	JJ
cord-276456-oa6hh7ky	29	23	layers	layer	NNS
cord-276456-oa6hh7ky	29	24	merge	merge	VBP
cord-276456-oa6hh7ky	29	25	into	into	IN
cord-276456-oa6hh7ky	29	26	one	one	CD
cord-276456-oa6hh7ky	29	27	.	.	.
cord-276456-oa6hh7ky	30	1	But	but	CC
cord-276456-oa6hh7ky	30	2	these	these	DT
cord-276456-oa6hh7ky	30	3	layers	layer	NNS
cord-276456-oa6hh7ky	30	4	can	can	MD
cord-276456-oa6hh7ky	30	5	dive	dive	VB
cord-276456-oa6hh7ky	30	6	into	into	IN
cord-276456-oa6hh7ky	30	7	the	the	DT
cord-276456-oa6hh7ky	30	8	interior	interior	NN
cord-276456-oa6hh7ky	30	9	,	,	,
cord-276456-oa6hh7ky	30	10	any	any	DT
cord-276456-oa6hh7ky	30	11	given	give	VBN
cord-276456-oa6hh7ky	30	12	molecule	molecule	NN
cord-276456-oa6hh7ky	30	13	is	be	VBZ
cord-276456-oa6hh7ky	30	14	an	an	DT
cord-276456-oa6hh7ky	30	15	ephemeral	ephemeral	JJ
cord-276456-oa6hh7ky	30	16	rather	rather	RB
cord-276456-oa6hh7ky	30	17	than	than	IN
cord-276456-oa6hh7ky	30	18	integral	integral	JJ
cord-276456-oa6hh7ky	30	19	part	part	NN
cord-276456-oa6hh7ky	30	20	of	of	IN
cord-276456-oa6hh7ky	30	21	the	the	DT
cord-276456-oa6hh7ky	30	22	droplet	droplet	NN
cord-276456-oa6hh7ky	30	23	's	's	POS
cord-276456-oa6hh7ky	30	24	surface	surface	NN
cord-276456-oa6hh7ky	30	25	.	.	.
cord-276456-oa6hh7ky	31	1	Films	film	NNS
cord-276456-oa6hh7ky	31	2	made	make	VBN
cord-276456-oa6hh7ky	31	3	of	of	IN
cord-276456-oa6hh7ky	31	4	soap	soap	NN
cord-276456-oa6hh7ky	31	5	or	or	CC
cord-276456-oa6hh7ky	31	6	protein	protein	NN
cord-276456-oa6hh7ky	31	7	(	(	-LRB-
cord-276456-oa6hh7ky	31	8	e.g.	e.g.	RB
cord-276456-oa6hh7ky	31	9	,	,	,
cord-276456-oa6hh7ky	31	10	bubbles	bubble	NNS
cord-276456-oa6hh7ky	31	11	made	make	VBN
cord-276456-oa6hh7ky	31	12	by	by	IN
cord-276456-oa6hh7ky	31	13	children	child	NNS
cord-276456-oa6hh7ky	31	14	from	from	IN
cord-276456-oa6hh7ky	31	15	detergent	detergent	NN
cord-276456-oa6hh7ky	31	16	or	or	CC
cord-276456-oa6hh7ky	31	17	blowing	blowing	NN
cord-276456-oa6hh7ky	31	18	bubbles	bubble	NNS
cord-276456-oa6hh7ky	31	19	in	in	IN
cord-276456-oa6hh7ky	31	20	their	-PRON-	PRP$
cord-276456-oa6hh7ky	31	21	milk	milk	NN
cord-276456-oa6hh7ky	31	22	)	)	-RRB-
cord-276456-oa6hh7ky	31	23	provide	provide	VB
cord-276456-oa6hh7ky	31	24	a	a	DT
cord-276456-oa6hh7ky	31	25	better	well	JJR
cord-276456-oa6hh7ky	31	26	model	model	NN
cord-276456-oa6hh7ky	31	27	,	,	,
cord-276456-oa6hh7ky	31	28	and	and	CC
cord-276456-oa6hh7ky	31	29	we	-PRON-	PRP
cord-276456-oa6hh7ky	31	30	have	have	VBP
cord-276456-oa6hh7ky	31	31	all	all	DT
cord-276456-oa6hh7ky	31	32	seen	see	VBN
cord-276456-oa6hh7ky	31	33	them	-PRON-	PRP
cord-276456-oa6hh7ky	31	34	fuse	fuse	VB
cord-276456-oa6hh7ky	31	35	and	and	CC
cord-276456-oa6hh7ky	31	36	lyse	lyse	VB
cord-276456-oa6hh7ky	31	37	before	before	IN
cord-276456-oa6hh7ky	31	38	our	-PRON-	PRP$
cord-276456-oa6hh7ky	31	39	eyes	eye	NNS
cord-276456-oa6hh7ky	31	40	.	.	.
cord-276456-oa6hh7ky	32	1	However	however	RB
cord-276456-oa6hh7ky	32	2	,	,	,
cord-276456-oa6hh7ky	32	3	they	-PRON-	PRP
cord-276456-oa6hh7ky	32	4	also	also	RB
cord-276456-oa6hh7ky	32	5	have	have	VBP
cord-276456-oa6hh7ky	32	6	surfaces	surface	NNS
cord-276456-oa6hh7ky	32	7	that	that	WDT
cord-276456-oa6hh7ky	32	8	can	can	MD
cord-276456-oa6hh7ky	32	9	exchange	exchange	VB
cord-276456-oa6hh7ky	32	10	with	with	IN
cord-276456-oa6hh7ky	32	11	a	a	DT
cord-276456-oa6hh7ky	32	12	bulky	bulky	JJ
cord-276456-oa6hh7ky	32	13	interior	interior	NN
cord-276456-oa6hh7ky	32	14	,	,	,
cord-276456-oa6hh7ky	32	15	and	and	CC
cord-276456-oa6hh7ky	32	16	their	-PRON-	PRP$
cord-276456-oa6hh7ky	32	17	width	width	NN
cord-276456-oa6hh7ky	32	18	can	can	MD
cord-276456-oa6hh7ky	32	19	vary	vary	VB
cord-276456-oa6hh7ky	32	20	.	.	.
cord-276456-oa6hh7ky	33	1	These	these	DT
cord-276456-oa6hh7ky	33	2	films	film	NNS
cord-276456-oa6hh7ky	33	3	are	be	VBP
cord-276456-oa6hh7ky	33	4	unlike	unlike	IN
cord-276456-oa6hh7ky	33	5	the	the	DT
cord-276456-oa6hh7ky	33	6	biological	biological	JJ
cord-276456-oa6hh7ky	33	7	membrane	membrane	NN
cord-276456-oa6hh7ky	33	8	in	in	IN
cord-276456-oa6hh7ky	33	9	that	that	IN
cord-276456-oa6hh7ky	33	10	their	-PRON-	PRP$
cord-276456-oa6hh7ky	33	11	apolar	apolar	NNP
cord-276456-oa6hh7ky	33	12	moities	moitie	NNS
cord-276456-oa6hh7ky	33	13	face	face	VBP
cord-276456-oa6hh7ky	33	14	the	the	DT
cord-276456-oa6hh7ky	33	15	low	low	JJ
cord-276456-oa6hh7ky	33	16	dielectric	dielectric	NN
cord-276456-oa6hh7ky	33	17	air	air	NN
cord-276456-oa6hh7ky	33	18	rather	rather	RB
cord-276456-oa6hh7ky	33	19	than	than	IN
cord-276456-oa6hh7ky	33	20	the	the	DT
cord-276456-oa6hh7ky	33	21	high	high	JJ
cord-276456-oa6hh7ky	33	22	dielectric	dielectric	NN
cord-276456-oa6hh7ky	33	23	watery	watery	JJ
cord-276456-oa6hh7ky	33	24	interior	interior	NN
cord-276456-oa6hh7ky	33	25	of	of	IN
cord-276456-oa6hh7ky	33	26	the	the	DT
cord-276456-oa6hh7ky	33	27	film	film	NN
cord-276456-oa6hh7ky	33	28	.	.	.
cord-276456-oa6hh7ky	34	1	The	the	DT
cord-276456-oa6hh7ky	34	2	biological	biological	JJ
cord-276456-oa6hh7ky	34	3	membrane	membrane	NN
cord-276456-oa6hh7ky	34	4	is	be	VBZ
cord-276456-oa6hh7ky	34	5	composed	compose	VBN
cord-276456-oa6hh7ky	34	6	of	of	IN
cord-276456-oa6hh7ky	34	7	lipids	lipid	NNS
cord-276456-oa6hh7ky	34	8	,	,	,
cord-276456-oa6hh7ky	34	9	proteins	protein	NNS
cord-276456-oa6hh7ky	34	10	,	,	,
cord-276456-oa6hh7ky	34	11	and	and	CC
cord-276456-oa6hh7ky	34	12	carbohydrates	carbohydrate	NNS
cord-276456-oa6hh7ky	34	13	of	of	IN
cord-276456-oa6hh7ky	34	14	varying	vary	VBG
cord-276456-oa6hh7ky	34	15	chemical	chemical	NN
cord-276456-oa6hh7ky	34	16	structure	structure	NN
cord-276456-oa6hh7ky	34	17	.	.	.
cord-276456-oa6hh7ky	35	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	35	2	exists	exist	VBZ
cord-276456-oa6hh7ky	35	3	within	within	IN
cord-276456-oa6hh7ky	35	4	the	the	DT
cord-276456-oa6hh7ky	35	5	context	context	NN
cord-276456-oa6hh7ky	35	6	of	of	IN
cord-276456-oa6hh7ky	35	7	an	an	DT
cord-276456-oa6hh7ky	35	8	aqueous	aqueous	JJ
cord-276456-oa6hh7ky	35	9	cellular	cellular	JJ
cord-276456-oa6hh7ky	35	10	environment	environment	NN
cord-276456-oa6hh7ky	35	11	that	that	WDT
cord-276456-oa6hh7ky	35	12	prefers	prefer	VBZ
cord-276456-oa6hh7ky	35	13	to	to	TO
cord-276456-oa6hh7ky	35	14	avoid	avoid	VB
cord-276456-oa6hh7ky	35	15	the	the	DT
cord-276456-oa6hh7ky	35	16	interior	interior	NN
cord-276456-oa6hh7ky	35	17	of	of	IN
cord-276456-oa6hh7ky	35	18	the	the	DT
cord-276456-oa6hh7ky	35	19	membrane	membrane	NN
cord-276456-oa6hh7ky	35	20	fusion	fusion	NN
cord-276456-oa6hh7ky	35	21	.	.	.
cord-276456-oa6hh7ky	36	1	This	this	DT
cord-276456-oa6hh7ky	36	2	entropically	entropically	RB
cord-276456-oa6hh7ky	36	3	-	-	HYPH
cord-276456-oa6hh7ky	36	4	driven	drive	VBN
cord-276456-oa6hh7ky	36	5	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	36	6	effect	effect	NN
cord-276456-oa6hh7ky	36	7	leads	lead	VBZ
cord-276456-oa6hh7ky	36	8	to	to	IN
cord-276456-oa6hh7ky	36	9	two	two	CD
cord-276456-oa6hh7ky	36	10	important	important	JJ
cord-276456-oa6hh7ky	36	11	constraints	constraint	NNS
cord-276456-oa6hh7ky	36	12	on	on	IN
cord-276456-oa6hh7ky	36	13	topological	topological	JJ
cord-276456-oa6hh7ky	36	14	transformations	transformation	NNS
cord-276456-oa6hh7ky	36	15	,	,	,
cord-276456-oa6hh7ky	36	16	(	(	-LRB-
cord-276456-oa6hh7ky	36	17	1	1	LS
cord-276456-oa6hh7ky	36	18	)	)	-RRB-
cord-276456-oa6hh7ky	36	19	a	a	DT
cord-276456-oa6hh7ky	36	20	tension	tension	NN
cord-276456-oa6hh7ky	36	21	at	at	IN
cord-276456-oa6hh7ky	36	22	the	the	DT
cord-276456-oa6hh7ky	36	23	interface	interface	NN
cord-276456-oa6hh7ky	36	24	of	of	IN
cord-276456-oa6hh7ky	36	25	the	the	DT
cord-276456-oa6hh7ky	36	26	polar	polar	JJ
cord-276456-oa6hh7ky	36	27	head	head	NN
cord-276456-oa6hh7ky	36	28	groups	group	NNS
cord-276456-oa6hh7ky	36	29	of	of	IN
cord-276456-oa6hh7ky	36	30	the	the	DT
cord-276456-oa6hh7ky	36	31	lipids	lipid	NNS
cord-276456-oa6hh7ky	36	32	to	to	TO
cord-276456-oa6hh7ky	36	33	resist	resist	VB
cord-276456-oa6hh7ky	36	34	any	any	DT
cord-276456-oa6hh7ky	36	35	stretching	stretching	NN
cord-276456-oa6hh7ky	36	36	,	,	,
cord-276456-oa6hh7ky	36	37	and	and	CC
cord-276456-oa6hh7ky	36	38	(	(	-LRB-
cord-276456-oa6hh7ky	36	39	2	2	LS
cord-276456-oa6hh7ky	36	40	)	)	-RRB-
cord-276456-oa6hh7ky	36	41	a	a	DT
cord-276456-oa6hh7ky	36	42	uniform	uniform	JJ
cord-276456-oa6hh7ky	36	43	thickness	thickness	NN
cord-276456-oa6hh7ky	36	44	which	which	WDT
cord-276456-oa6hh7ky	36	45	is	be	VBZ
cord-276456-oa6hh7ky	36	46	primarily	primarily	RB
cord-276456-oa6hh7ky	36	47	determined	determine	VBN
cord-276456-oa6hh7ky	36	48	by	by	IN
cord-276456-oa6hh7ky	36	49	the	the	DT
cord-276456-oa6hh7ky	36	50	lipid	lipid	NN
cord-276456-oa6hh7ky	36	51	constituents	constituent	NNS
cord-276456-oa6hh7ky	36	52	.	.	.
cord-276456-oa6hh7ky	37	1	Bilayers	Bilayers	NNP
cord-276456-oa6hh7ky	37	2	made	make	VBN
cord-276456-oa6hh7ky	37	3	from	from	IN
cord-276456-oa6hh7ky	37	4	phospholipids	phospholipid	NNS
cord-276456-oa6hh7ky	37	5	have	have	VBP
cord-276456-oa6hh7ky	37	6	been	be	VBN
cord-276456-oa6hh7ky	37	7	used	use	VBN
cord-276456-oa6hh7ky	37	8	extensively	extensively	RB
cord-276456-oa6hh7ky	37	9	to	to	TO
cord-276456-oa6hh7ky	37	10	study	study	VB
cord-276456-oa6hh7ky	37	11	the	the	DT
cord-276456-oa6hh7ky	37	12	fusion	fusion	NN
cord-276456-oa6hh7ky	37	13	process	process	NN
cord-276456-oa6hh7ky	37	14	,	,	,
cord-276456-oa6hh7ky	37	15	and	and	CC
cord-276456-oa6hh7ky	37	16	more	more	RBR
cord-276456-oa6hh7ky	37	17	recently	recently	RB
cord-276456-oa6hh7ky	37	18	the	the	DT
cord-276456-oa6hh7ky	37	19	fission	fission	NN
cord-276456-oa6hh7ky	37	20	process	process	NN
cord-276456-oa6hh7ky	37	21	.	.	.
cord-276456-oa6hh7ky	38	1	Since	since	IN
cord-276456-oa6hh7ky	38	2	the	the	DT
cord-276456-oa6hh7ky	38	3	number	number	NN
cord-276456-oa6hh7ky	38	4	of	of	IN
cord-276456-oa6hh7ky	38	5	phospholipids	phospholipid	NNS
cord-276456-oa6hh7ky	38	6	molecules	molecule	NNS
cord-276456-oa6hh7ky	38	7	far	far	RB
cord-276456-oa6hh7ky	38	8	outnumber	outnumber	VBP
cord-276456-oa6hh7ky	38	9	the	the	DT
cord-276456-oa6hh7ky	38	10	other	other	JJ
cord-276456-oa6hh7ky	38	11	constituents	constituent	NNS
cord-276456-oa6hh7ky	38	12	,	,	,
cord-276456-oa6hh7ky	38	13	membrane	membrane	NN
cord-276456-oa6hh7ky	38	14	entropy	entropy	NN
cord-276456-oa6hh7ky	38	15	is	be	VBZ
cord-276456-oa6hh7ky	38	16	dominated	dominate	VBN
cord-276456-oa6hh7ky	38	17	by	by	IN
cord-276456-oa6hh7ky	38	18	the	the	DT
cord-276456-oa6hh7ky	38	19	thermodynamics	thermodynamic	NNS
cord-276456-oa6hh7ky	38	20	of	of	IN
cord-276456-oa6hh7ky	38	21	the	the	DT
cord-276456-oa6hh7ky	38	22	lipids	lipid	NNS
cord-276456-oa6hh7ky	38	23	themselves	-PRON-	PRP
cord-276456-oa6hh7ky	38	24	,	,	,
cord-276456-oa6hh7ky	38	25	and	and	CC
cord-276456-oa6hh7ky	38	26	thus	thus	RB
cord-276456-oa6hh7ky	38	27	it	-PRON-	PRP
cord-276456-oa6hh7ky	38	28	is	be	VBZ
cord-276456-oa6hh7ky	38	29	likely	likely	JJ
cord-276456-oa6hh7ky	38	30	that	that	IN
cord-276456-oa6hh7ky	38	31	whatever	whatever	WDT
cord-276456-oa6hh7ky	38	32	is	be	VBZ
cord-276456-oa6hh7ky	38	33	learned	learn	VBN
cord-276456-oa6hh7ky	38	34	from	from	IN
cord-276456-oa6hh7ky	38	35	investigations	investigation	NNS
cord-276456-oa6hh7ky	38	36	of	of	IN
cord-276456-oa6hh7ky	38	37	lipid	lipid	NN
cord-276456-oa6hh7ky	38	38	bilayer	bilayer	NN
cord-276456-oa6hh7ky	38	39	fusion	fusion	NN
cord-276456-oa6hh7ky	38	40	will	will	MD
cord-276456-oa6hh7ky	38	41	inform	inform	VB
cord-276456-oa6hh7ky	38	42	us	-PRON-	PRP
cord-276456-oa6hh7ky	38	43	about	about	IN
cord-276456-oa6hh7ky	38	44	biological	biological	JJ
cord-276456-oa6hh7ky	38	45	membrane	membrane	NN
cord-276456-oa6hh7ky	38	46	fusion	fusion	NN
cord-276456-oa6hh7ky	38	47	.	.	.
cord-276456-oa6hh7ky	39	1	Indeed	indeed	RB
cord-276456-oa6hh7ky	39	2	,	,	,
cord-276456-oa6hh7ky	39	3	it	-PRON-	PRP
cord-276456-oa6hh7ky	39	4	seems	seem	VBZ
cord-276456-oa6hh7ky	39	5	that	that	IN
cord-276456-oa6hh7ky	39	6	many	many	JJ
cord-276456-oa6hh7ky	39	7	of	of	IN
cord-276456-oa6hh7ky	39	8	the	the	DT
cord-276456-oa6hh7ky	39	9	key	key	JJ
cord-276456-oa6hh7ky	39	10	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	39	11	of	of	IN
cord-276456-oa6hh7ky	39	12	membrane	membrane	NN
cord-276456-oa6hh7ky	39	13	fusion	fusion	NN
cord-276456-oa6hh7ky	39	14	are	be	VBP
cord-276456-oa6hh7ky	39	15	the	the	DT
cord-276456-oa6hh7ky	39	16	same	same	JJ
cord-276456-oa6hh7ky	39	17	in	in	IN
cord-276456-oa6hh7ky	39	18	the	the	DT
cord-276456-oa6hh7ky	39	19	fusion	fusion	NN
cord-276456-oa6hh7ky	39	20	of	of	IN
cord-276456-oa6hh7ky	39	21	synthetic	synthetic	JJ
cord-276456-oa6hh7ky	39	22	and	and	CC
cord-276456-oa6hh7ky	39	23	natural	natural	JJ
cord-276456-oa6hh7ky	39	24	membranes	membrane	NNS
cord-276456-oa6hh7ky	39	25	.	.	.
cord-276456-oa6hh7ky	40	1	[	[	-LRB-
cord-276456-oa6hh7ky	40	2	1	1	CD
cord-276456-oa6hh7ky	40	3	]	]	-RRB-
cord-276456-oa6hh7ky	40	4	[	[	-LRB-
cord-276456-oa6hh7ky	40	5	2	2	CD
cord-276456-oa6hh7ky	40	6	]	]	-RRB-
cord-276456-oa6hh7ky	40	7	[	[	-LRB-
cord-276456-oa6hh7ky	40	8	3	3	LS
cord-276456-oa6hh7ky	40	9	]	]	-RRB-
cord-276456-oa6hh7ky	40	10	We	-PRON-	PRP
cord-276456-oa6hh7ky	40	11	will	will	MD
cord-276456-oa6hh7ky	40	12	not	not	RB
cord-276456-oa6hh7ky	40	13	cover	cover	VB
cord-276456-oa6hh7ky	40	14	this	this	DT
cord-276456-oa6hh7ky	40	15	ground	ground	NN
cord-276456-oa6hh7ky	40	16	,	,	,
cord-276456-oa6hh7ky	40	17	as	as	IN
cord-276456-oa6hh7ky	40	18	many	many	JJ
cord-276456-oa6hh7ky	40	19	excellent	excellent	JJ
cord-276456-oa6hh7ky	40	20	reviews	review	NNS
cord-276456-oa6hh7ky	40	21	serve	serve	VBP
cord-276456-oa6hh7ky	40	22	this	this	DT
cord-276456-oa6hh7ky	40	23	purpose	purpose	NN
cord-276456-oa6hh7ky	40	24	.	.	.
cord-276456-oa6hh7ky	41	1	[	[	-LRB-
cord-276456-oa6hh7ky	41	2	4	4	CD
cord-276456-oa6hh7ky	41	3	]	]	-RRB-
cord-276456-oa6hh7ky	41	4	[	[	-LRB-
cord-276456-oa6hh7ky	41	5	5	5	CD
cord-276456-oa6hh7ky	41	6	]	]	-RRB-
cord-276456-oa6hh7ky	41	7	[	[	-LRB-
cord-276456-oa6hh7ky	41	8	6	6	CD
cord-276456-oa6hh7ky	41	9	]	]	-RRB-
cord-276456-oa6hh7ky	41	10	[	[	-LRB-
cord-276456-oa6hh7ky	41	11	7	7	CD
cord-276456-oa6hh7ky	41	12	]	]	-RRB-
cord-276456-oa6hh7ky	42	1	[	[	-LRB-
cord-276456-oa6hh7ky	42	2	8	8	CD
cord-276456-oa6hh7ky	42	3	]	]	-RRB-
cord-276456-oa6hh7ky	42	4	[	[	-LRB-
cord-276456-oa6hh7ky	42	5	9	9	CD
cord-276456-oa6hh7ky	42	6	]	]	-RRB-
cord-276456-oa6hh7ky	42	7	[	[	-LRB-
cord-276456-oa6hh7ky	42	8	10	10	CD
cord-276456-oa6hh7ky	42	9	]	]	-RRB-
cord-276456-oa6hh7ky	43	1	Rather	rather	RB
cord-276456-oa6hh7ky	43	2	,	,	,
cord-276456-oa6hh7ky	43	3	in	in	IN
cord-276456-oa6hh7ky	43	4	this	this	DT
cord-276456-oa6hh7ky	43	5	chapter	chapter	NN
cord-276456-oa6hh7ky	43	6	we	-PRON-	PRP
cord-276456-oa6hh7ky	43	7	will	will	MD
cord-276456-oa6hh7ky	43	8	introduce	introduce	VB
cord-276456-oa6hh7ky	43	9	a	a	DT
cord-276456-oa6hh7ky	43	10	number	number	NN
cord-276456-oa6hh7ky	43	11	of	of	IN
cord-276456-oa6hh7ky	43	12	controversies	controversy	NNS
cord-276456-oa6hh7ky	43	13	that	that	WDT
cord-276456-oa6hh7ky	43	14	the	the	DT
cord-276456-oa6hh7ky	43	15	reader	reader	NN
cord-276456-oa6hh7ky	43	16	may	may	MD
cord-276456-oa6hh7ky	43	17	be	be	VB
cord-276456-oa6hh7ky	43	18	stimulated	stimulate	VBN
cord-276456-oa6hh7ky	43	19	to	to	TO
cord-276456-oa6hh7ky	43	20	solve	solve	VB
cord-276456-oa6hh7ky	43	21	.	.	.
cord-276456-oa6hh7ky	44	1	In	in	IN
cord-276456-oa6hh7ky	44	2	general	general	JJ
cord-276456-oa6hh7ky	44	3	there	there	EX
cord-276456-oa6hh7ky	44	4	are	be	VBP
cord-276456-oa6hh7ky	44	5	a	a	DT
cord-276456-oa6hh7ky	44	6	number	number	NN
cord-276456-oa6hh7ky	44	7	of	of	IN
cord-276456-oa6hh7ky	44	8	energy	energy	NN
cord-276456-oa6hh7ky	44	9	barriers	barrier	NNS
cord-276456-oa6hh7ky	44	10	that	that	WDT
cord-276456-oa6hh7ky	44	11	prevent	prevent	VBP
cord-276456-oa6hh7ky	44	12	fusion	fusion	NN
cord-276456-oa6hh7ky	44	13	from	from	IN
cord-276456-oa6hh7ky	44	14	proceeding	proceed	VBG
cord-276456-oa6hh7ky	44	15	spontaneously	spontaneously	RB
cord-276456-oa6hh7ky	44	16	.	.	.
cord-276456-oa6hh7ky	45	1	First	first	RB
cord-276456-oa6hh7ky	45	2	and	and	CC
cord-276456-oa6hh7ky	45	3	foremost	foremost	RB
cord-276456-oa6hh7ky	45	4	,	,	,
cord-276456-oa6hh7ky	45	5	there	there	EX
cord-276456-oa6hh7ky	45	6	is	be	VBZ
cord-276456-oa6hh7ky	45	7	the	the	DT
cord-276456-oa6hh7ky	45	8	fact	fact	NN
cord-276456-oa6hh7ky	45	9	that	that	IN
cord-276456-oa6hh7ky	45	10	in	in	IN
cord-276456-oa6hh7ky	45	11	distilled	distil	VBN
cord-276456-oa6hh7ky	45	12	water	water	NN
cord-276456-oa6hh7ky	45	13	and	and	CC
cord-276456-oa6hh7ky	45	14	dilute	dilute	VB
cord-276456-oa6hh7ky	45	15	solutions	solution	NNS
cord-276456-oa6hh7ky	45	16	of	of	IN
cord-276456-oa6hh7ky	45	17	monovalent	monovalent	JJ
cord-276456-oa6hh7ky	45	18	salt	salt	NN
cord-276456-oa6hh7ky	45	19	,	,	,
cord-276456-oa6hh7ky	45	20	all	all	DT
cord-276456-oa6hh7ky	45	21	lipid	lipid	NN
cord-276456-oa6hh7ky	45	22	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	45	23	resist	resist	VBP
cord-276456-oa6hh7ky	45	24	close	close	JJ
cord-276456-oa6hh7ky	45	25	approach	approach	NN
cord-276456-oa6hh7ky	45	26	with	with	IN
cord-276456-oa6hh7ky	45	27	a	a	DT
cord-276456-oa6hh7ky	45	28	force	force	NN
cord-276456-oa6hh7ky	45	29	that	that	WDT
cord-276456-oa6hh7ky	45	30	rises	rise	VBZ
cord-276456-oa6hh7ky	45	31	exponentially	exponentially	RB
cord-276456-oa6hh7ky	45	32	from	from	IN
cord-276456-oa6hh7ky	45	33	an	an	DT
cord-276456-oa6hh7ky	45	34	equilibrium	equilibrium	NN
cord-276456-oa6hh7ky	45	35	distance	distance	NN
cord-276456-oa6hh7ky	45	36	of	of	IN
cord-276456-oa6hh7ky	45	37	about	about	RB
cord-276456-oa6hh7ky	45	38	2	2	CD
cord-276456-oa6hh7ky	45	39	nm	nm	NN
cord-276456-oa6hh7ky	45	40	.	.	.
cord-276456-oa6hh7ky	46	1	With	with	IN
cord-276456-oa6hh7ky	46	2	divalent	divalent	JJ
cord-276456-oa6hh7ky	46	3	cations	cation	NNS
cord-276456-oa6hh7ky	46	4	in	in	IN
cord-276456-oa6hh7ky	46	5	the	the	DT
cord-276456-oa6hh7ky	46	6	solution	solution	NN
cord-276456-oa6hh7ky	46	7	bathing	bathe	VBG
cord-276456-oa6hh7ky	46	8	the	the	DT
cord-276456-oa6hh7ky	46	9	membranes	membrane	NNS
cord-276456-oa6hh7ky	46	10	,	,	,
cord-276456-oa6hh7ky	46	11	close	close	JJ
cord-276456-oa6hh7ky	46	12	approach	approach	NN
cord-276456-oa6hh7ky	46	13	is	be	VBZ
cord-276456-oa6hh7ky	46	14	possible	possible	JJ
cord-276456-oa6hh7ky	46	15	,	,	,
cord-276456-oa6hh7ky	46	16	depending	depend	VBG
cord-276456-oa6hh7ky	46	17	upon	upon	IN
cord-276456-oa6hh7ky	46	18	the	the	DT
cord-276456-oa6hh7ky	46	19	lipid	lipid	NN
cord-276456-oa6hh7ky	46	20	composition	composition	NN
cord-276456-oa6hh7ky	46	21	.	.	.
cord-276456-oa6hh7ky	47	1	This	this	DT
cord-276456-oa6hh7ky	47	2	is	be	VBZ
cord-276456-oa6hh7ky	47	3	readily	readily	RB
cord-276456-oa6hh7ky	47	4	seen	see	VBN
cord-276456-oa6hh7ky	47	5	as	as	IN
cord-276456-oa6hh7ky	47	6	exchange	exchange	NN
cord-276456-oa6hh7ky	47	7	of	of	IN
cord-276456-oa6hh7ky	47	8	components	component	NNS
cord-276456-oa6hh7ky	47	9	in	in	IN
cord-276456-oa6hh7ky	47	10	the	the	DT
cord-276456-oa6hh7ky	47	11	contacting	contact	VBG
cord-276456-oa6hh7ky	47	12	leaflets	leaflet	NNS
cord-276456-oa6hh7ky	47	13	.	.	.
cord-276456-oa6hh7ky	48	1	11	11	CD
cord-276456-oa6hh7ky	48	2	,	,	,
cord-276456-oa6hh7ky	48	3	12	12	CD
cord-276456-oa6hh7ky	48	4	Presumably	presumably	RB
cord-276456-oa6hh7ky	48	5	,	,	,
cord-276456-oa6hh7ky	48	6	this	this	DT
cord-276456-oa6hh7ky	48	7	occurs	occur	VBZ
cord-276456-oa6hh7ky	48	8	through	through	IN
cord-276456-oa6hh7ky	48	9	minute	minute	NN
cord-276456-oa6hh7ky	48	10	and	and	CC
cord-276456-oa6hh7ky	48	11	transient	transient	JJ
cord-276456-oa6hh7ky	48	12	contact	contact	NN
cord-276456-oa6hh7ky	48	13	sites	site	NNS
cord-276456-oa6hh7ky	48	14	in	in	IN
cord-276456-oa6hh7ky	48	15	which	which	WDT
cord-276456-oa6hh7ky	48	16	the	the	DT
cord-276456-oa6hh7ky	48	17	contacting	contact	VBG
cord-276456-oa6hh7ky	48	18	leaflets	leaflet	NNS
cord-276456-oa6hh7ky	48	19	are	be	VBP
cord-276456-oa6hh7ky	48	20	joined	join	VBN
cord-276456-oa6hh7ky	48	21	(	(	-LRB-
cord-276456-oa6hh7ky	48	22	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	48	23	)	)	-RRB-
cord-276456-oa6hh7ky	48	24	.	.	.
cord-276456-oa6hh7ky	49	1	However	however	RB
cord-276456-oa6hh7ky	49	2	,	,	,
cord-276456-oa6hh7ky	49	3	this	this	DT
cord-276456-oa6hh7ky	49	4	is	be	VBZ
cord-276456-oa6hh7ky	49	5	not	not	RB
cord-276456-oa6hh7ky	49	6	generally	generally	RB
cord-276456-oa6hh7ky	49	7	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	49	8	either	either	RB
cord-276456-oa6hh7ky	49	9	for	for	IN
cord-276456-oa6hh7ky	49	10	membrane	membrane	NN
cord-276456-oa6hh7ky	49	11	fusion	fusion	NN
cord-276456-oa6hh7ky	49	12	or	or	CC
cord-276456-oa6hh7ky	49	13	the	the	DT
cord-276456-oa6hh7ky	49	14	formation	formation	NN
cord-276456-oa6hh7ky	49	15	of	of	IN
cord-276456-oa6hh7ky	49	16	an	an	DT
cord-276456-oa6hh7ky	49	17	extended	extended	JJ
cord-276456-oa6hh7ky	49	18	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	49	19	composed	compose	VBN
cord-276456-oa6hh7ky	49	20	of	of	IN
cord-276456-oa6hh7ky	49	21	the	the	DT
cord-276456-oa6hh7ky	49	22	outer	outer	JJ
cord-276456-oa6hh7ky	49	23	,	,	,
cord-276456-oa6hh7ky	49	24	or	or	CC
cord-276456-oa6hh7ky	49	25	non	non	JJ
cord-276456-oa6hh7ky	49	26	-	-	JJ
cord-276456-oa6hh7ky	49	27	contacting	contact	VBG
cord-276456-oa6hh7ky	49	28	leaflets	leaflet	NNS
cord-276456-oa6hh7ky	49	29	of	of	IN
cord-276456-oa6hh7ky	49	30	the	the	DT
cord-276456-oa6hh7ky	49	31	joining	join	VBG
cord-276456-oa6hh7ky	49	32	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	49	33	(	(	-LRB-
cord-276456-oa6hh7ky	49	34	termed	term	VBN
cord-276456-oa6hh7ky	49	35	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	49	36	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	49	37	)	)	-RRB-
cord-276456-oa6hh7ky	49	38	,	,	,
cord-276456-oa6hh7ky	49	39	13	13	CD
cord-276456-oa6hh7ky	49	40	for	for	IN
cord-276456-oa6hh7ky	49	41	there	there	EX
cord-276456-oa6hh7ky	49	42	are	be	VBP
cord-276456-oa6hh7ky	49	43	energetic	energetic	JJ
cord-276456-oa6hh7ky	49	44	restrictions	restriction	NNS
cord-276456-oa6hh7ky	49	45	to	to	IN
cord-276456-oa6hh7ky	49	46	the	the	DT
cord-276456-oa6hh7ky	49	47	widening	widening	NN
cord-276456-oa6hh7ky	49	48	of	of	IN
cord-276456-oa6hh7ky	49	49	the	the	DT
cord-276456-oa6hh7ky	49	50	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	49	51	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	49	52	that	that	WDT
cord-276456-oa6hh7ky	49	53	joins	join	VBZ
cord-276456-oa6hh7ky	49	54	the	the	DT
cord-276456-oa6hh7ky	49	55	two	two	CD
cord-276456-oa6hh7ky	49	56	leaflets	leaflet	NNS
cord-276456-oa6hh7ky	49	57	(	(	-LRB-
cord-276456-oa6hh7ky	49	58	termed	term	VBD
cord-276456-oa6hh7ky	49	59	a	a	DT
cord-276456-oa6hh7ky	49	60	stalk	stalk	NN
cord-276456-oa6hh7ky	49	61	,	,	,
cord-276456-oa6hh7ky	49	62	[	[	-LRB-
cord-276456-oa6hh7ky	49	63	14	14	CD
cord-276456-oa6hh7ky	49	64	]	]	-RRB-
cord-276456-oa6hh7ky	49	65	[	[	-LRB-
cord-276456-oa6hh7ky	49	66	15	15	CD
cord-276456-oa6hh7ky	49	67	]	]	-RRB-
cord-276456-oa6hh7ky	49	68	[	[	-LRB-
cord-276456-oa6hh7ky	49	69	16	16	CD
cord-276456-oa6hh7ky	49	70	]	]	-RRB-
cord-276456-oa6hh7ky	49	71	.	.	.
cord-276456-oa6hh7ky	50	1	The	the	DT
cord-276456-oa6hh7ky	50	2	main	main	JJ
cord-276456-oa6hh7ky	50	3	way	way	NN
cord-276456-oa6hh7ky	50	4	to	to	TO
cord-276456-oa6hh7ky	50	5	facilitate	facilitate	VB
cord-276456-oa6hh7ky	50	6	the	the	DT
cord-276456-oa6hh7ky	50	7	formation	formation	NN
cord-276456-oa6hh7ky	50	8	of	of	IN
cord-276456-oa6hh7ky	50	9	a	a	DT
cord-276456-oa6hh7ky	50	10	stable	stable	JJ
cord-276456-oa6hh7ky	50	11	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	50	12	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	50	13	is	be	VBZ
cord-276456-oa6hh7ky	50	14	to	to	TO
cord-276456-oa6hh7ky	50	15	add	add	VB
cord-276456-oa6hh7ky	50	16	hydrocarbon	hydrocarbon	NN
cord-276456-oa6hh7ky	50	17	solvent	solvent	NN
cord-276456-oa6hh7ky	50	18	to	to	IN
cord-276456-oa6hh7ky	50	19	the	the	DT
cord-276456-oa6hh7ky	50	20	membrane	membrane	NN
cord-276456-oa6hh7ky	50	21	,	,	,
cord-276456-oa6hh7ky	50	22	so	so	IN
cord-276456-oa6hh7ky	50	23	as	as	IN
cord-276456-oa6hh7ky	50	24	to	to	TO
cord-276456-oa6hh7ky	50	25	lower	lower	VB
cord-276456-oa6hh7ky	50	26	the	the	DT
cord-276456-oa6hh7ky	50	27	energy	energy	NN
cord-276456-oa6hh7ky	50	28	of	of	IN
cord-276456-oa6hh7ky	50	29	the	the	DT
cord-276456-oa6hh7ky	50	30	three	three	CD
cord-276456-oa6hh7ky	50	31	-	-	HYPH
cord-276456-oa6hh7ky	50	32	way	way	NN
cord-276456-oa6hh7ky	50	33	junction	junction	NN
cord-276456-oa6hh7ky	50	34	between	between	IN
cord-276456-oa6hh7ky	50	35	the	the	DT
cord-276456-oa6hh7ky	50	36	two	two	CD
cord-276456-oa6hh7ky	50	37	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	50	38	and	and	CC
cord-276456-oa6hh7ky	50	39	the	the	DT
cord-276456-oa6hh7ky	50	40	joined	joined	JJ
cord-276456-oa6hh7ky	50	41	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	50	42	.	.	.
cord-276456-oa6hh7ky	51	1	17	17	CD
cord-276456-oa6hh7ky	51	2	,	,	,
cord-276456-oa6hh7ky	51	3	18	18	CD
cord-276456-oa6hh7ky	52	1	Once	once	RB
cord-276456-oa6hh7ky	52	2	there	there	EX
cord-276456-oa6hh7ky	52	3	is	be	VBZ
cord-276456-oa6hh7ky	52	4	a	a	DT
cord-276456-oa6hh7ky	52	5	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	52	6	junction	junction	NN
cord-276456-oa6hh7ky	52	7	,	,	,
cord-276456-oa6hh7ky	52	8	another	another	DT
cord-276456-oa6hh7ky	52	9	way	way	NN
cord-276456-oa6hh7ky	52	10	to	to	TO
cord-276456-oa6hh7ky	52	11	complete	complete	VB
cord-276456-oa6hh7ky	52	12	fusion	fusion	NN
cord-276456-oa6hh7ky	52	13	is	be	VBZ
cord-276456-oa6hh7ky	52	14	via	via	IN
cord-276456-oa6hh7ky	52	15	the	the	DT
cord-276456-oa6hh7ky	52	16	formation	formation	NN
cord-276456-oa6hh7ky	52	17	of	of	IN
cord-276456-oa6hh7ky	52	18	a	a	DT
cord-276456-oa6hh7ky	52	19	lipidic	lipidic	JJ
cord-276456-oa6hh7ky	52	20	pore	pore	NN
cord-276456-oa6hh7ky	52	21	within	within	IN
cord-276456-oa6hh7ky	52	22	the	the	DT
cord-276456-oa6hh7ky	52	23	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	52	24	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	52	25	.	.	.
cord-276456-oa6hh7ky	53	1	19	19	CD
cord-276456-oa6hh7ky	54	1	This	this	DT
cord-276456-oa6hh7ky	54	2	can	can	MD
cord-276456-oa6hh7ky	54	3	be	be	VB
cord-276456-oa6hh7ky	54	4	facilitated	facilitate	VBN
cord-276456-oa6hh7ky	54	5	by	by	IN
cord-276456-oa6hh7ky	54	6	either	either	CC
cord-276456-oa6hh7ky	54	7	increasing	increase	VBG
cord-276456-oa6hh7ky	54	8	membrane	membrane	NN
cord-276456-oa6hh7ky	54	9	tension	tension	NN
cord-276456-oa6hh7ky	54	10	,	,	,
cord-276456-oa6hh7ky	54	11	or	or	CC
cord-276456-oa6hh7ky	54	12	by	by	IN
cord-276456-oa6hh7ky	54	13	adding	add	VBG
cord-276456-oa6hh7ky	54	14	lipids	lipid	NNS
cord-276456-oa6hh7ky	54	15	whose	whose	WP$
cord-276456-oa6hh7ky	54	16	composition	composition	NN
cord-276456-oa6hh7ky	54	17	favors	favor	VBZ
cord-276456-oa6hh7ky	54	18	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	54	19	pore	pore	NN
cord-276456-oa6hh7ky	54	20	formation	formation	NN
cord-276456-oa6hh7ky	54	21	.	.	.
cord-276456-oa6hh7ky	55	1	20,21	20,21	CD
cord-276456-oa6hh7ky	55	2	(	(	-LRB-
cord-276456-oa6hh7ky	55	3	Formally	formally	RB
cord-276456-oa6hh7ky	55	4	,	,	,
cord-276456-oa6hh7ky	55	5	such	such	JJ
cord-276456-oa6hh7ky	55	6	lipids	lipid	NNS
cord-276456-oa6hh7ky	55	7	would	would	MD
cord-276456-oa6hh7ky	55	8	be	be	VB
cord-276456-oa6hh7ky	55	9	defined	define	VBN
cord-276456-oa6hh7ky	55	10	as	as	IN
cord-276456-oa6hh7ky	55	11	having	have	VBG
cord-276456-oa6hh7ky	55	12	positive	positive	JJ
cord-276456-oa6hh7ky	55	13	monolayer	monolayer	NN
cord-276456-oa6hh7ky	55	14	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	55	15	curvature	curvature	NN
cord-276456-oa6hh7ky	55	16	.	.	.
cord-276456-oa6hh7ky	56	1	22	22	LS
cord-276456-oa6hh7ky	56	2	)	)	-RRB-
cord-276456-oa6hh7ky	57	1	Thus	thus	RB
cord-276456-oa6hh7ky	57	2	it	-PRON-	PRP
cord-276456-oa6hh7ky	57	3	is	be	VBZ
cord-276456-oa6hh7ky	57	4	possible	possible	JJ
cord-276456-oa6hh7ky	57	5	to	to	TO
cord-276456-oa6hh7ky	57	6	set	set	VB
cord-276456-oa6hh7ky	57	7	up	up	RP
cord-276456-oa6hh7ky	57	8	ionic	ionic	JJ
cord-276456-oa6hh7ky	57	9	and	and	CC
cord-276456-oa6hh7ky	57	10	membrane	membrane	NN
cord-276456-oa6hh7ky	57	11	compositional	compositional	JJ
cord-276456-oa6hh7ky	57	12	situations	situation	NNS
cord-276456-oa6hh7ky	57	13	which	which	WDT
cord-276456-oa6hh7ky	57	14	allow	allow	VBP
cord-276456-oa6hh7ky	57	15	the	the	DT
cord-276456-oa6hh7ky	57	16	demonstration	demonstration	NN
cord-276456-oa6hh7ky	57	17	of	of	IN
cord-276456-oa6hh7ky	57	18	membrane	membrane	NN
cord-276456-oa6hh7ky	57	19	fusion	fusion	NN
cord-276456-oa6hh7ky	57	20	and	and	CC
cord-276456-oa6hh7ky	57	21	its	-PRON-	PRP$
cord-276456-oa6hh7ky	57	22	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	57	23	without	without	IN
cord-276456-oa6hh7ky	57	24	adding	add	VBG
cord-276456-oa6hh7ky	57	25	energy	energy	NN
cord-276456-oa6hh7ky	57	26	,	,	,
cord-276456-oa6hh7ky	57	27	thus	thus	RB
cord-276456-oa6hh7ky	57	28	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	57	29	fusion	fusion	NN
cord-276456-oa6hh7ky	57	30	is	be	VBZ
cord-276456-oa6hh7ky	57	31	possible	possible	JJ
cord-276456-oa6hh7ky	57	32	under	under	IN
cord-276456-oa6hh7ky	57	33	a	a	DT
cord-276456-oa6hh7ky	57	34	set	set	NN
cord-276456-oa6hh7ky	57	35	of	of	IN
cord-276456-oa6hh7ky	57	36	restricted	restricted	JJ
cord-276456-oa6hh7ky	57	37	conditions	condition	NNS
cord-276456-oa6hh7ky	57	38	.	.	.
cord-276456-oa6hh7ky	58	1	What	what	WP
cord-276456-oa6hh7ky	58	2	is	be	VBZ
cord-276456-oa6hh7ky	58	3	not	not	RB
cord-276456-oa6hh7ky	58	4	at	at	RB
cord-276456-oa6hh7ky	58	5	all	all	RB
cord-276456-oa6hh7ky	58	6	clear	clear	JJ
cord-276456-oa6hh7ky	58	7	is	be	VBZ
cord-276456-oa6hh7ky	58	8	the	the	DT
cord-276456-oa6hh7ky	58	9	favorable	favorable	JJ
cord-276456-oa6hh7ky	58	10	effect	effect	NN
cord-276456-oa6hh7ky	58	11	of	of	IN
cord-276456-oa6hh7ky	58	12	tension	tension	NN
cord-276456-oa6hh7ky	58	13	on	on	IN
cord-276456-oa6hh7ky	58	14	the	the	DT
cord-276456-oa6hh7ky	58	15	formation	formation	NN
cord-276456-oa6hh7ky	58	16	kinetics	kinetics	NN
cord-276456-oa6hh7ky	58	17	of	of	IN
cord-276456-oa6hh7ky	58	18	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	58	19	contacts	contact	NNS
cord-276456-oa6hh7ky	58	20	,	,	,
cord-276456-oa6hh7ky	58	21	and	and	CC
cord-276456-oa6hh7ky	58	22	how	how	WRB
cord-276456-oa6hh7ky	58	23	the	the	DT
cord-276456-oa6hh7ky	58	24	huge	huge	JJ
cord-276456-oa6hh7ky	58	25	hydration	hydration	NN
cord-276456-oa6hh7ky	58	26	repulsion	repulsion	NN
cord-276456-oa6hh7ky	58	27	between	between	IN
cord-276456-oa6hh7ky	58	28	contacting	contact	VBG
cord-276456-oa6hh7ky	58	29	monolayers	monolayer	NNS
cord-276456-oa6hh7ky	58	30	is	be	VBZ
cord-276456-oa6hh7ky	58	31	breached	breach	VBN
cord-276456-oa6hh7ky	58	32	during	during	IN
cord-276456-oa6hh7ky	58	33	the	the	DT
cord-276456-oa6hh7ky	58	34	tension	tension	NN
cord-276456-oa6hh7ky	58	35	-	-	HYPH
cord-276456-oa6hh7ky	58	36	driven	drive	VBN
cord-276456-oa6hh7ky	58	37	fusion	fusion	NN
cord-276456-oa6hh7ky	58	38	of	of	IN
cord-276456-oa6hh7ky	58	39	liposomes	liposome	NNS
cord-276456-oa6hh7ky	58	40	to	to	IN
cord-276456-oa6hh7ky	58	41	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	58	42	.	.	.
cord-276456-oa6hh7ky	59	1	20	20	CD
cord-276456-oa6hh7ky	60	1	The	the	DT
cord-276456-oa6hh7ky	60	2	fusion	fusion	NN
cord-276456-oa6hh7ky	60	3	pore	pore	NN
cord-276456-oa6hh7ky	60	4	links	link	VBZ
cord-276456-oa6hh7ky	60	5	the	the	DT
cord-276456-oa6hh7ky	60	6	interior	interior	NN
cord-276456-oa6hh7ky	60	7	of	of	IN
cord-276456-oa6hh7ky	60	8	a	a	DT
cord-276456-oa6hh7ky	60	9	vesicle	vesicle	NN
cord-276456-oa6hh7ky	60	10	to	to	IN
cord-276456-oa6hh7ky	60	11	the	the	DT
cord-276456-oa6hh7ky	60	12	external	external	JJ
cord-276456-oa6hh7ky	60	13	space	space	NN
cord-276456-oa6hh7ky	60	14	,	,	,
cord-276456-oa6hh7ky	60	15	or	or	CC
cord-276456-oa6hh7ky	60	16	the	the	DT
cord-276456-oa6hh7ky	60	17	interior	interior	NN
cord-276456-oa6hh7ky	60	18	of	of	IN
cord-276456-oa6hh7ky	60	19	a	a	DT
cord-276456-oa6hh7ky	60	20	virus	virus	NN
cord-276456-oa6hh7ky	60	21	to	to	IN
cord-276456-oa6hh7ky	60	22	the	the	DT
cord-276456-oa6hh7ky	60	23	cytoplasm	cytoplasm	NN
cord-276456-oa6hh7ky	60	24	.	.	.
cord-276456-oa6hh7ky	61	1	A	a	DT
cord-276456-oa6hh7ky	61	2	relatively	relatively	RB
cord-276456-oa6hh7ky	61	3	long	long	RB
cord-276456-oa6hh7ky	61	4	-	-	HYPH
cord-276456-oa6hh7ky	61	5	lived	live	VBN
cord-276456-oa6hh7ky	61	6	fusion	fusion	NN
cord-276456-oa6hh7ky	61	7	pore	pore	NN
cord-276456-oa6hh7ky	61	8	is	be	VBZ
cord-276456-oa6hh7ky	61	9	universal	universal	JJ
cord-276456-oa6hh7ky	61	10	in	in	IN
cord-276456-oa6hh7ky	61	11	biological	biological	JJ
cord-276456-oa6hh7ky	61	12	fusion	fusion	NN
cord-276456-oa6hh7ky	61	13	,	,	,
cord-276456-oa6hh7ky	61	14	regardless	regardless	RB
cord-276456-oa6hh7ky	61	15	of	of	IN
cord-276456-oa6hh7ky	61	16	whether	whether	IN
cord-276456-oa6hh7ky	61	17	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	61	18	,	,	,
cord-276456-oa6hh7ky	61	19	viral	viral	JJ
cord-276456-oa6hh7ky	61	20	fusion	fusion	NN
cord-276456-oa6hh7ky	61	21	,	,	,
cord-276456-oa6hh7ky	61	22	or	or	CC
cord-276456-oa6hh7ky	61	23	cell	cell	NN
cord-276456-oa6hh7ky	61	24	-	-	HYPH
cord-276456-oa6hh7ky	61	25	cell	cell	NN
cord-276456-oa6hh7ky	61	26	fusion	fusion	NN
cord-276456-oa6hh7ky	61	27	is	be	VBZ
cord-276456-oa6hh7ky	61	28	studied	study	VBN
cord-276456-oa6hh7ky	61	29	.	.	.
cord-276456-oa6hh7ky	62	1	Since	since	IN
cord-276456-oa6hh7ky	62	2	its	-PRON-	PRP$
cord-276456-oa6hh7ky	62	3	discovery	discovery	NN
cord-276456-oa6hh7ky	62	4	as	as	IN
cord-276456-oa6hh7ky	62	5	a	a	DT
cord-276456-oa6hh7ky	62	6	sub	sub	JJ
cord-276456-oa6hh7ky	62	7	-	-	JJ
cord-276456-oa6hh7ky	62	8	ultrastructural	ultrastructural	JJ
cord-276456-oa6hh7ky	62	9	entity	entity	NN
cord-276456-oa6hh7ky	62	10	,	,	,
cord-276456-oa6hh7ky	62	11	its	-PRON-	PRP$
cord-276456-oa6hh7ky	62	12	architecture	architecture	NN
cord-276456-oa6hh7ky	62	13	and	and	CC
cord-276456-oa6hh7ky	62	14	composition	composition	NN
cord-276456-oa6hh7ky	62	15	has	have	VBZ
cord-276456-oa6hh7ky	62	16	been	be	VBN
cord-276456-oa6hh7ky	62	17	in	in	IN
cord-276456-oa6hh7ky	62	18	debate	debate	NN
cord-276456-oa6hh7ky	62	19	.	.	.
cord-276456-oa6hh7ky	63	1	In	in	IN
cord-276456-oa6hh7ky	63	2	part	part	NN
cord-276456-oa6hh7ky	63	3	,	,	,
cord-276456-oa6hh7ky	63	4	this	this	DT
cord-276456-oa6hh7ky	63	5	is	be	VBZ
cord-276456-oa6hh7ky	63	6	because	because	IN
cord-276456-oa6hh7ky	63	7	of	of	IN
cord-276456-oa6hh7ky	63	8	two	two	CD
cord-276456-oa6hh7ky	63	9	very	very	RB
cord-276456-oa6hh7ky	63	10	different	different	JJ
cord-276456-oa6hh7ky	63	11	views	view	NNS
cord-276456-oa6hh7ky	63	12	of	of	IN
cord-276456-oa6hh7ky	63	13	the	the	DT
cord-276456-oa6hh7ky	63	14	mechanism	mechanism	NN
cord-276456-oa6hh7ky	63	15	of	of	IN
cord-276456-oa6hh7ky	63	16	membrane	membrane	NN
cord-276456-oa6hh7ky	63	17	fusion	fusion	NN
cord-276456-oa6hh7ky	63	18	:	:	:
cord-276456-oa6hh7ky	63	19	lipid	lipid	NN
cord-276456-oa6hh7ky	63	20	centric	centric	NN
cord-276456-oa6hh7ky	63	21	and	and	CC
cord-276456-oa6hh7ky	63	22	protein	protein	NN
cord-276456-oa6hh7ky	63	23	centric	centric	NNP
cord-276456-oa6hh7ky	63	24	.	.	.
cord-276456-oa6hh7ky	64	1	In	in	IN
cord-276456-oa6hh7ky	64	2	the	the	DT
cord-276456-oa6hh7ky	64	3	lipid	lipid	NN
cord-276456-oa6hh7ky	64	4	centric	centric	NN
cord-276456-oa6hh7ky	64	5	view	view	NN
cord-276456-oa6hh7ky	64	6	,	,	,
cord-276456-oa6hh7ky	64	7	proteins	protein	NNS
cord-276456-oa6hh7ky	64	8	surround	surround	VBP
cord-276456-oa6hh7ky	64	9	a	a	DT
cord-276456-oa6hh7ky	64	10	fusion	fusion	NN
cord-276456-oa6hh7ky	64	11	site	site	NN
cord-276456-oa6hh7ky	64	12	,	,	,
cord-276456-oa6hh7ky	64	13	and	and	CC
cord-276456-oa6hh7ky	64	14	the	the	DT
cord-276456-oa6hh7ky	64	15	conformational	conformational	JJ
cord-276456-oa6hh7ky	64	16	energy	energy	NN
cord-276456-oa6hh7ky	64	17	of	of	IN
cord-276456-oa6hh7ky	64	18	the	the	DT
cord-276456-oa6hh7ky	64	19	protein	protein	NN
cord-276456-oa6hh7ky	64	20	(	(	-LRB-
cord-276456-oa6hh7ky	64	21	as	as	IN
cord-276456-oa6hh7ky	64	22	it	-PRON-	PRP
cord-276456-oa6hh7ky	64	23	transitions	transition	VBZ
cord-276456-oa6hh7ky	64	24	from	from	IN
cord-276456-oa6hh7ky	64	25	a	a	DT
cord-276456-oa6hh7ky	64	26	pre	pre	JJ
cord-276456-oa6hh7ky	64	27	-	-	NN
cord-276456-oa6hh7ky	64	28	fusion	fusion	NN
cord-276456-oa6hh7ky	64	29	to	to	IN
cord-276456-oa6hh7ky	64	30	a	a	DT
cord-276456-oa6hh7ky	64	31	post	post	JJ
cord-276456-oa6hh7ky	64	32	-	-	JJ
cord-276456-oa6hh7ky	64	33	fusion	fusion	JJ
cord-276456-oa6hh7ky	64	34	form	form	NN
cord-276456-oa6hh7ky	64	35	)	)	-RRB-
cord-276456-oa6hh7ky	64	36	is	be	VBZ
cord-276456-oa6hh7ky	64	37	harnessed	harness	VBN
cord-276456-oa6hh7ky	64	38	into	into	IN
cord-276456-oa6hh7ky	64	39	stressing	stress	VBG
cord-276456-oa6hh7ky	64	40	the	the	DT
cord-276456-oa6hh7ky	64	41	encircled	encircle	VBN
cord-276456-oa6hh7ky	64	42	lipids	lipid	NNS
cord-276456-oa6hh7ky	64	43	to	to	IN
cord-276456-oa6hh7ky	64	44	the	the	DT
cord-276456-oa6hh7ky	64	45	point	point	NN
cord-276456-oa6hh7ky	64	46	of	of	IN
cord-276456-oa6hh7ky	64	47	a	a	DT
cord-276456-oa6hh7ky	64	48	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	64	49	transition	transition	NN
cord-276456-oa6hh7ky	64	50	in	in	IN
cord-276456-oa6hh7ky	64	51	topology	topology	NN
cord-276456-oa6hh7ky	64	52	along	along	IN
cord-276456-oa6hh7ky	64	53	a	a	DT
cord-276456-oa6hh7ky	64	54	well	well	RB
cord-276456-oa6hh7ky	64	55	-	-	HYPH
cord-276456-oa6hh7ky	64	56	studied	study	VBN
cord-276456-oa6hh7ky	64	57	set	set	NN
cord-276456-oa6hh7ky	64	58	of	of	IN
cord-276456-oa6hh7ky	64	59	molecular	molecular	JJ
cord-276456-oa6hh7ky	64	60	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	64	61	,	,	,
cord-276456-oa6hh7ky	65	1	first	first	RB
cord-276456-oa6hh7ky	65	2	a	a	DT
cord-276456-oa6hh7ky	65	3	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	66	1	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	66	2	-the	-the	DT
cord-276456-oa6hh7ky	66	3	stalk	stalk	NN
cord-276456-oa6hh7ky	66	4	-and	-and	.
cord-276456-oa6hh7ky	67	1	then	then	RB
cord-276456-oa6hh7ky	67	2	the	the	DT
cord-276456-oa6hh7ky	67	3	fusion	fusion	NN
cord-276456-oa6hh7ky	67	4	pore	pore	NN
cord-276456-oa6hh7ky	67	5	(	(	-LRB-
cord-276456-oa6hh7ky	67	6	Figure	figure	NN
cord-276456-oa6hh7ky	67	7	1	1	CD
cord-276456-oa6hh7ky	67	8	)	)	-RRB-
cord-276456-oa6hh7ky	67	9	.	.	.
cord-276456-oa6hh7ky	68	1	21	21	CD
cord-276456-oa6hh7ky	68	2	,	,	,
cord-276456-oa6hh7ky	68	3	24	24	CD
cord-276456-oa6hh7ky	68	4	,	,	,
cord-276456-oa6hh7ky	68	5	25	25	CD
cord-276456-oa6hh7ky	69	1	The	the	DT
cord-276456-oa6hh7ky	69	2	prediction	prediction	NN
cord-276456-oa6hh7ky	69	3	of	of	IN
cord-276456-oa6hh7ky	69	4	this	this	DT
cord-276456-oa6hh7ky	69	5	hypothesis	hypothesis	NN
cord-276456-oa6hh7ky	69	6	is	be	VBZ
cord-276456-oa6hh7ky	69	7	clear	clear	JJ
cord-276456-oa6hh7ky	69	8	:	:	:
cord-276456-oa6hh7ky	69	9	the	the	DT
cord-276456-oa6hh7ky	69	10	proteins	protein	NNS
cord-276456-oa6hh7ky	69	11	should	should	MD
cord-276456-oa6hh7ky	69	12	be	be	VB
cord-276456-oa6hh7ky	69	13	outside	outside	IN
cord-276456-oa6hh7ky	69	14	of	of	IN
cord-276456-oa6hh7ky	69	15	an	an	DT
cord-276456-oa6hh7ky	69	16	hourglass	hourglass	NN
cord-276456-oa6hh7ky	69	17	-	-	HYPH
cord-276456-oa6hh7ky	69	18	shaped	shape	VBN
cord-276456-oa6hh7ky	69	19	pore	pore	NN
cord-276456-oa6hh7ky	69	20	scaffolded	scaffold	VBN
cord-276456-oa6hh7ky	69	21	by	by	IN
cord-276456-oa6hh7ky	69	22	proteins	protein	NNS
cord-276456-oa6hh7ky	69	23	.	.	.
cord-276456-oa6hh7ky	70	1	In	in	IN
cord-276456-oa6hh7ky	70	2	the	the	DT
cord-276456-oa6hh7ky	70	3	protein	protein	NN
cord-276456-oa6hh7ky	70	4	-	-	HYPH
cord-276456-oa6hh7ky	70	5	centric	centric	NN
cord-276456-oa6hh7ky	70	6	view	view	NN
cord-276456-oa6hh7ky	70	7	,	,	,
cord-276456-oa6hh7ky	70	8	proteins	protein	NNS
cord-276456-oa6hh7ky	70	9	link	link	VBP
cord-276456-oa6hh7ky	70	10	up	up	RP
cord-276456-oa6hh7ky	70	11	the	the	DT
cord-276456-oa6hh7ky	70	12	two	two	CD
cord-276456-oa6hh7ky	70	13	membranes	membrane	NNS
cord-276456-oa6hh7ky	70	14	that	that	WDT
cord-276456-oa6hh7ky	70	15	are	be	VBP
cord-276456-oa6hh7ky	70	16	to	to	TO
cord-276456-oa6hh7ky	70	17	fuse	fuse	VB
cord-276456-oa6hh7ky	70	18	and	and	CC
cord-276456-oa6hh7ky	70	19	make	make	VB
cord-276456-oa6hh7ky	70	20	a	a	DT
cord-276456-oa6hh7ky	70	21	solid	solid	JJ
cord-276456-oa6hh7ky	70	22	proteinaceous	proteinaceous	JJ
cord-276456-oa6hh7ky	70	23	connection	connection	NN
cord-276456-oa6hh7ky	70	24	,	,	,
cord-276456-oa6hh7ky	70	25	a	a	DT
cord-276456-oa6hh7ky	70	26	potential	potential	JJ
cord-276456-oa6hh7ky	70	27	channel	channel	NN
cord-276456-oa6hh7ky	70	28	that	that	WDT
cord-276456-oa6hh7ky	70	29	is	be	VBZ
cord-276456-oa6hh7ky	70	30	first	first	RB
cord-276456-oa6hh7ky	70	31	closed	closed	JJ
cord-276456-oa6hh7ky	70	32	,	,	,
cord-276456-oa6hh7ky	70	33	then	then	RB
cord-276456-oa6hh7ky	70	34	opens	open	VBZ
cord-276456-oa6hh7ky	70	35	to	to	TO
cord-276456-oa6hh7ky	70	36	form	form	VB
cord-276456-oa6hh7ky	70	37	the	the	DT
cord-276456-oa6hh7ky	70	38	initial	initial	JJ
cord-276456-oa6hh7ky	70	39	fusion	fusion	NN
cord-276456-oa6hh7ky	70	40	pore	pore	NN
cord-276456-oa6hh7ky	70	41	.	.	.
cord-276456-oa6hh7ky	71	1	3	3	LS
cord-276456-oa6hh7ky	72	1	The	the	DT
cord-276456-oa6hh7ky	72	2	prediction	prediction	NN
cord-276456-oa6hh7ky	72	3	of	of	IN
cord-276456-oa6hh7ky	72	4	this	this	DT
cord-276456-oa6hh7ky	72	5	hypothesis	hypothesis	NN
cord-276456-oa6hh7ky	72	6	is	be	VBZ
cord-276456-oa6hh7ky	72	7	also	also	RB
cord-276456-oa6hh7ky	72	8	clear	clear	JJ
cord-276456-oa6hh7ky	72	9	:	:	:
cord-276456-oa6hh7ky	72	10	the	the	DT
cord-276456-oa6hh7ky	72	11	proteins	protein	NNS
cord-276456-oa6hh7ky	72	12	should	should	MD
cord-276456-oa6hh7ky	72	13	be	be	VB
cord-276456-oa6hh7ky	72	14	at	at	IN
cord-276456-oa6hh7ky	72	15	the	the	DT
cord-276456-oa6hh7ky	72	16	center	center	NN
cord-276456-oa6hh7ky	72	17	of	of	IN
cord-276456-oa6hh7ky	72	18	the	the	DT
cord-276456-oa6hh7ky	72	19	pore	pore	NN
cord-276456-oa6hh7ky	72	20	,	,	,
cord-276456-oa6hh7ky	72	21	surrounded	surrounded	JJ
cord-276456-oa6hh7ky	72	22	and	and	CC
cord-276456-oa6hh7ky	72	23	later	later	RB
cord-276456-oa6hh7ky	72	24	infiltrated	infiltrate	VBN
cord-276456-oa6hh7ky	72	25	by	by	IN
cord-276456-oa6hh7ky	72	26	lipids	lipid	NNS
cord-276456-oa6hh7ky	72	27	as	as	IN
cord-276456-oa6hh7ky	72	28	the	the	DT
cord-276456-oa6hh7ky	72	29	proteins	protein	NNS
cord-276456-oa6hh7ky	72	30	dissociate	dissociate	VBP
cord-276456-oa6hh7ky	72	31	to	to	TO
cord-276456-oa6hh7ky	72	32	guide	guide	VB
cord-276456-oa6hh7ky	72	33	the	the	DT
cord-276456-oa6hh7ky	72	34	topological	topological	JJ
cord-276456-oa6hh7ky	72	35	change	change	NN
cord-276456-oa6hh7ky	72	36	of	of	IN
cord-276456-oa6hh7ky	72	37	the	the	DT
cord-276456-oa6hh7ky	72	38	lipids	lipid	NNS
cord-276456-oa6hh7ky	72	39	.	.	.
cord-276456-oa6hh7ky	73	1	A	a	DT
cord-276456-oa6hh7ky	73	2	direct	direct	JJ
cord-276456-oa6hh7ky	73	3	method	method	NN
cord-276456-oa6hh7ky	73	4	is	be	VBZ
cord-276456-oa6hh7ky	73	5	needed	need	VBN
cord-276456-oa6hh7ky	73	6	to	to	TO
cord-276456-oa6hh7ky	73	7	determine	determine	VB
cord-276456-oa6hh7ky	73	8	which	which	WDT
cord-276456-oa6hh7ky	73	9	of	of	IN
cord-276456-oa6hh7ky	73	10	these	these	DT
cord-276456-oa6hh7ky	73	11	predictions	prediction	NNS
cord-276456-oa6hh7ky	73	12	is	be	VBZ
cord-276456-oa6hh7ky	73	13	met	meet	VBN
cord-276456-oa6hh7ky	73	14	during	during	IN
cord-276456-oa6hh7ky	73	15	different	different	JJ
cord-276456-oa6hh7ky	73	16	instances	instance	NNS
cord-276456-oa6hh7ky	73	17	of	of	IN
cord-276456-oa6hh7ky	73	18	biological	biological	JJ
cord-276456-oa6hh7ky	73	19	fusion	fusion	NN
cord-276456-oa6hh7ky	73	20	.	.	.
cord-276456-oa6hh7ky	74	1	One	one	CD
cord-276456-oa6hh7ky	74	2	of	of	IN
cord-276456-oa6hh7ky	74	3	the	the	DT
cord-276456-oa6hh7ky	74	4	abiding	abide	VBG
cord-276456-oa6hh7ky	74	5	mysteries	mystery	NNS
cord-276456-oa6hh7ky	74	6	in	in	IN
cord-276456-oa6hh7ky	74	7	biology	biology	NN
cord-276456-oa6hh7ky	74	8	is	be	VBZ
cord-276456-oa6hh7ky	74	9	the	the	DT
cord-276456-oa6hh7ky	74	10	great	great	JJ
cord-276456-oa6hh7ky	74	11	speed	speed	NN
cord-276456-oa6hh7ky	74	12	that	that	IN
cord-276456-oa6hh7ky	74	13	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	74	14	transmission	transmission	NN
cord-276456-oa6hh7ky	74	15	is	be	VBZ
cord-276456-oa6hh7ky	74	16	capable	capable	JJ
cord-276456-oa6hh7ky	74	17	of	of	IN
cord-276456-oa6hh7ky	74	18	,	,	,
cord-276456-oa6hh7ky	74	19	with	with	IN
cord-276456-oa6hh7ky	74	20	fusion	fusion	NN
cord-276456-oa6hh7ky	74	21	of	of	IN
cord-276456-oa6hh7ky	74	22	some	some	DT
cord-276456-oa6hh7ky	74	23	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	74	24	beginning	begin	VBG
cord-276456-oa6hh7ky	74	25	some	some	DT
cord-276456-oa6hh7ky	74	26	tens	ten	NNS
cord-276456-oa6hh7ky	74	27	of	of	IN
cord-276456-oa6hh7ky	74	28	microseconds	microsecond	NNS
cord-276456-oa6hh7ky	74	29	after	after	IN
cord-276456-oa6hh7ky	74	30	Ca	Ca	NNP
cord-276456-oa6hh7ky	75	1	2	2	LS
cord-276456-oa6hh7ky	75	2	þ	þ	CD
cord-276456-oa6hh7ky	75	3	floods	flood	NNS
cord-276456-oa6hh7ky	75	4	the	the	DT
cord-276456-oa6hh7ky	75	5	presynaptic	presynaptic	JJ
cord-276456-oa6hh7ky	75	6	intracellular	intracellular	JJ
cord-276456-oa6hh7ky	75	7	release	release	NN
cord-276456-oa6hh7ky	75	8	site	site	NN
cord-276456-oa6hh7ky	75	9	.	.	.
cord-276456-oa6hh7ky	76	1	26	26	CD
cord-276456-oa6hh7ky	76	2	,	,	,
cord-276456-oa6hh7ky	76	3	27	27	CD
cord-276456-oa6hh7ky	77	1	This	this	DT
cord-276456-oa6hh7ky	77	2	finding	finding	NN
cord-276456-oa6hh7ky	77	3	leads	lead	VBZ
cord-276456-oa6hh7ky	77	4	one	one	PRP
cord-276456-oa6hh7ky	77	5	to	to	TO
cord-276456-oa6hh7ky	77	6	wonder	wonder	VB
cord-276456-oa6hh7ky	77	7	if	if	IN
cord-276456-oa6hh7ky	77	8	there	there	EX
cord-276456-oa6hh7ky	77	9	is	be	VBZ
cord-276456-oa6hh7ky	77	10	a	a	DT
cord-276456-oa6hh7ky	77	11	physical	physical	JJ
cord-276456-oa6hh7ky	77	12	state	state	NN
cord-276456-oa6hh7ky	77	13	to	to	IN
cord-276456-oa6hh7ky	77	14	a	a	DT
cord-276456-oa6hh7ky	77	15	small	small	JJ
cord-276456-oa6hh7ky	77	16	population	population	NN
cord-276456-oa6hh7ky	77	17	of	of	IN
cord-276456-oa6hh7ky	77	18	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	77	19	whose	whose	WP$
cord-276456-oa6hh7ky	77	20	fusion	fusion	NN
cord-276456-oa6hh7ky	77	21	machinery	machinery	NN
cord-276456-oa6hh7ky	77	22	is	be	VBZ
cord-276456-oa6hh7ky	77	23	beyond	beyond	IN
cord-276456-oa6hh7ky	77	24	the	the	DT
cord-276456-oa6hh7ky	77	25	stages	stage	NNS
cord-276456-oa6hh7ky	77	26	of	of	IN
cord-276456-oa6hh7ky	77	27	priming	prime	VBG
cord-276456-oa6hh7ky	77	28	and	and	CC
cord-276456-oa6hh7ky	77	29	conformational	conformational	JJ
cord-276456-oa6hh7ky	77	30	change	change	NN
cord-276456-oa6hh7ky	77	31	.	.	.
cord-276456-oa6hh7ky	78	1	3	3	CD
cord-276456-oa6hh7ky	78	2	,	,	,
cord-276456-oa6hh7ky	78	3	28	28	CD
cord-276456-oa6hh7ky	78	4	There	there	EX
cord-276456-oa6hh7ky	78	5	are	be	VBP
cord-276456-oa6hh7ky	78	6	two	two	CD
cord-276456-oa6hh7ky	78	7	main	main	JJ
cord-276456-oa6hh7ky	78	8	proposals	proposal	NNS
cord-276456-oa6hh7ky	78	9	:	:	:
cord-276456-oa6hh7ky	78	10	1	1	LS
cord-276456-oa6hh7ky	78	11	.	.	.
cord-276456-oa6hh7ky	78	12	that	that	DT
cord-276456-oa6hh7ky	78	13	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	78	14	provides	provide	VBZ
cord-276456-oa6hh7ky	78	15	positive	positive	JJ
cord-276456-oa6hh7ky	78	16	curvature	curvature	NN
cord-276456-oa6hh7ky	78	17	stress	stress	NN
cord-276456-oa6hh7ky	78	18	that	that	WDT
cord-276456-oa6hh7ky	78	19	translates	translate	VBZ
cord-276456-oa6hh7ky	78	20	into	into	IN
cord-276456-oa6hh7ky	78	21	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	78	22	at	at	IN
cord-276456-oa6hh7ky	78	23	the	the	DT
cord-276456-oa6hh7ky	78	24	center	center	NN
cord-276456-oa6hh7ky	78	25	of	of	IN
cord-276456-oa6hh7ky	78	26	a	a	DT
cord-276456-oa6hh7ky	78	27	ring	ring	NN
cord-276456-oa6hh7ky	78	28	of	of	IN
cord-276456-oa6hh7ky	78	29	protein	protein	NN
cord-276456-oa6hh7ky	78	30	at	at	IN
cord-276456-oa6hh7ky	78	31	the	the	DT
cord-276456-oa6hh7ky	78	32	base	base	NN
cord-276456-oa6hh7ky	78	33	of	of	IN
cord-276456-oa6hh7ky	78	34	a	a	DT
cord-276456-oa6hh7ky	78	35	dimple	dimple	NN
cord-276456-oa6hh7ky	78	36	,	,	,
cord-276456-oa6hh7ky	78	37	29	29	CD
cord-276456-oa6hh7ky	78	38	and	and	CC
cord-276456-oa6hh7ky	78	39	2	2	CD
cord-276456-oa6hh7ky	78	40	.	.	.
cord-276456-oa6hh7ky	79	1	that	that	DT
cord-276456-oa6hh7ky	79	2	ring	ring	NN
cord-276456-oa6hh7ky	79	3	assemblies	assembly	NNS
cord-276456-oa6hh7ky	79	4	of	of	IN
cord-276456-oa6hh7ky	79	5	SNARE	snare	NN
cord-276456-oa6hh7ky	79	6	(	(	-LRB-
cord-276456-oa6hh7ky	79	7	soluble	soluble	JJ
cord-276456-oa6hh7ky	79	8	N	n	CD
cord-276456-oa6hh7ky	79	9	-	-	HYPH
cord-276456-oa6hh7ky	79	10	ethylmaleimidesensitive	ethylmaleimidesensitive	JJ
cord-276456-oa6hh7ky	79	11	factor	factor	NN
cord-276456-oa6hh7ky	79	12	attachment	attachment	NN
cord-276456-oa6hh7ky	79	13	protein	protein	NN
cord-276456-oa6hh7ky	79	14	(	(	-LRB-
cord-276456-oa6hh7ky	79	15	SNAP	snap	VB
cord-276456-oa6hh7ky	79	16	)	)	-RRB-
cord-276456-oa6hh7ky	79	17	receptor	receptor	NN
cord-276456-oa6hh7ky	79	18	)	)	-RRB-
cord-276456-oa6hh7ky	79	19	and	and	CC
cord-276456-oa6hh7ky	79	20	synaptotagmin	synaptotagmin	JJ
cord-276456-oa6hh7ky	79	21	complexes	complex	NNS
cord-276456-oa6hh7ky	79	22	form	form	VBP
cord-276456-oa6hh7ky	79	23	to	to	TO
cord-276456-oa6hh7ky	79	24	appropriately	appropriately	RB
cord-276456-oa6hh7ky	79	25	concentrate	concentrate	VB
cord-276456-oa6hh7ky	79	26	and	and	CC
cord-276456-oa6hh7ky	79	27	orient	orient	VB
cord-276456-oa6hh7ky	79	28	C2b	C2b	NNP
cord-276456-oa6hh7ky	79	29	domains	domain	NNS
cord-276456-oa6hh7ky	79	30	of	of	IN
cord-276456-oa6hh7ky	79	31	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	79	32	.	.	.
cord-276456-oa6hh7ky	80	1	2	2	LS
cord-276456-oa6hh7ky	81	1	This	this	DT
cord-276456-oa6hh7ky	81	2	ring	ring	NN
cord-276456-oa6hh7ky	81	3	of	of	IN
cord-276456-oa6hh7ky	81	4	ordered	order	VBN
cord-276456-oa6hh7ky	81	5	domains	domain	NNS
cord-276456-oa6hh7ky	81	6	effectively	effectively	RB
cord-276456-oa6hh7ky	81	7	creates	create	VBZ
cord-276456-oa6hh7ky	81	8	a	a	DT
cord-276456-oa6hh7ky	81	9	tube	tube	NN
cord-276456-oa6hh7ky	81	10	-	-	HYPH
cord-276456-oa6hh7ky	81	11	like	like	JJ
cord-276456-oa6hh7ky	81	12	scaffold	scaffold	NN
cord-276456-oa6hh7ky	81	13	of	of	IN
cord-276456-oa6hh7ky	81	14	positively	positively	RB
cord-276456-oa6hh7ky	81	15	charged	charge	VBN
cord-276456-oa6hh7ky	81	16	protein	protein	NN
cord-276456-oa6hh7ky	81	17	residues	residue	NNS
cord-276456-oa6hh7ky	81	18	that	that	WDT
cord-276456-oa6hh7ky	81	19	span	span	VBP
cord-276456-oa6hh7ky	81	20	the	the	DT
cord-276456-oa6hh7ky	81	21	two	two	CD
cord-276456-oa6hh7ky	81	22	membranes	membrane	NNS
cord-276456-oa6hh7ky	81	23	that	that	WDT
cord-276456-oa6hh7ky	81	24	are	be	VBP
cord-276456-oa6hh7ky	81	25	to	to	TO
cord-276456-oa6hh7ky	81	26	fuse	fuse	VB
cord-276456-oa6hh7ky	81	27	,	,	,
cord-276456-oa6hh7ky	81	28	a	a	DT
cord-276456-oa6hh7ky	81	29	favorable	favorable	JJ
cord-276456-oa6hh7ky	81	30	location	location	NN
cord-276456-oa6hh7ky	81	31	for	for	IN
cord-276456-oa6hh7ky	81	32	dimples	dimple	NNS
cord-276456-oa6hh7ky	81	33	of	of	IN
cord-276456-oa6hh7ky	81	34	membrane	membrane	NN
cord-276456-oa6hh7ky	81	35	to	to	TO
cord-276456-oa6hh7ky	81	36	approach	approach	VB
cord-276456-oa6hh7ky	81	37	each	each	DT
cord-276456-oa6hh7ky	81	38	other	other	JJ
cord-276456-oa6hh7ky	81	39	.	.	.
cord-276456-oa6hh7ky	82	1	In	in	IN
cord-276456-oa6hh7ky	82	2	other	other	JJ
cord-276456-oa6hh7ky	82	3	words	word	NNS
cord-276456-oa6hh7ky	82	4	,	,	,
cord-276456-oa6hh7ky	82	5	it	-PRON-	PRP
cord-276456-oa6hh7ky	82	6	would	would	MD
cord-276456-oa6hh7ky	82	7	be	be	VB
cord-276456-oa6hh7ky	82	8	an	an	DT
cord-276456-oa6hh7ky	82	9	electrostatic	electrostatic	JJ
cord-276456-oa6hh7ky	82	10	tunnel	tunnel	NN
cord-276456-oa6hh7ky	82	11	for	for	IN
cord-276456-oa6hh7ky	82	12	membrane	membrane	NN
cord-276456-oa6hh7ky	82	13	fusion	fusion	NN
cord-276456-oa6hh7ky	82	14	that	that	WDT
cord-276456-oa6hh7ky	82	15	is	be	VBZ
cord-276456-oa6hh7ky	82	16	extended	extend	VBN
cord-276456-oa6hh7ky	82	17	by	by	IN
cord-276456-oa6hh7ky	82	18	the	the	DT
cord-276456-oa6hh7ky	82	19	polybasic	polybasic	JJ
cord-276456-oa6hh7ky	82	20	linker	linker	NN
cord-276456-oa6hh7ky	82	21	regions	region	NNS
cord-276456-oa6hh7ky	82	22	of	of	IN
cord-276456-oa6hh7ky	82	23	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	82	24	and	and	CC
cord-276456-oa6hh7ky	82	25	synaptobrevin	synaptobrevin	NNP
cord-276456-oa6hh7ky	82	26	.	.	.
cord-276456-oa6hh7ky	83	1	3	3	LS
cord-276456-oa6hh7ky	83	2	Variations	variation	NNS
cord-276456-oa6hh7ky	83	3	of	of	IN
cord-276456-oa6hh7ky	83	4	this	this	DT
cord-276456-oa6hh7ky	83	5	model	model	NN
cord-276456-oa6hh7ky	83	6	can	can	MD
cord-276456-oa6hh7ky	83	7	account	account	VB
cord-276456-oa6hh7ky	83	8	for	for	IN
cord-276456-oa6hh7ky	83	9	many	many	JJ
cord-276456-oa6hh7ky	83	10	physiological	physiological	JJ
cord-276456-oa6hh7ky	83	11	pathways	pathway	NNS
cord-276456-oa6hh7ky	83	12	,	,	,
cord-276456-oa6hh7ky	83	13	including	include	VBG
cord-276456-oa6hh7ky	83	14	a	a	DT
cord-276456-oa6hh7ky	83	15	small	small	JJ
cord-276456-oa6hh7ky	83	16	fraction	fraction	NN
cord-276456-oa6hh7ky	83	17	of	of	IN
cord-276456-oa6hh7ky	83	18	the	the	DT
cord-276456-oa6hh7ky	83	19	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	83	20	that	that	WDT
cord-276456-oa6hh7ky	83	21	may	may	MD
cord-276456-oa6hh7ky	83	22	already	already	RB
cord-276456-oa6hh7ky	83	23	interacting	interact	VBG
cord-276456-oa6hh7ky	83	24	at	at	IN
cord-276456-oa6hh7ky	83	25	the	the	DT
cord-276456-oa6hh7ky	83	26	level	level	NN
cord-276456-oa6hh7ky	83	27	of	of	IN
cord-276456-oa6hh7ky	83	28	the	the	DT
cord-276456-oa6hh7ky	83	29	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	83	30	prior	prior	RB
cord-276456-oa6hh7ky	83	31	to	to	IN
cord-276456-oa6hh7ky	83	32	the	the	DT
cord-276456-oa6hh7ky	83	33	entry	entry	NN
cord-276456-oa6hh7ky	83	34	of	of	IN
cord-276456-oa6hh7ky	83	35	calcium	calcium	NN
cord-276456-oa6hh7ky	83	36	.	.	.
cord-276456-oa6hh7ky	84	1	What	what	WP
cord-276456-oa6hh7ky	84	2	is	be	VBZ
cord-276456-oa6hh7ky	84	3	the	the	DT
cord-276456-oa6hh7ky	84	4	role	role	NN
cord-276456-oa6hh7ky	84	5	of	of	IN
cord-276456-oa6hh7ky	84	6	calcium	calcium	NN
cord-276456-oa6hh7ky	84	7	once	once	IN
cord-276456-oa6hh7ky	84	8	it	-PRON-	PRP
cord-276456-oa6hh7ky	84	9	enters	enter	VBZ
cord-276456-oa6hh7ky	84	10	?	?	.
cord-276456-oa6hh7ky	85	1	First	first	RB
cord-276456-oa6hh7ky	85	2	,	,	,
cord-276456-oa6hh7ky	85	3	Ca	Ca	NNP
cord-276456-oa6hh7ky	85	4	2	2	CD
cord-276456-oa6hh7ky	85	5	þ	þ	NNP
cord-276456-oa6hh7ky	85	6	turns	turn	VBZ
cord-276456-oa6hh7ky	85	7	on	on	RP
cord-276456-oa6hh7ky	85	8	an	an	DT
cord-276456-oa6hh7ky	85	9	'	'	``
cord-276456-oa6hh7ky	85	10	electrostatic	electrostatic	JJ
cord-276456-oa6hh7ky	85	11	switch	switch	NN
cord-276456-oa6hh7ky	85	12	'	'	''
cord-276456-oa6hh7ky	85	13	initially	initially	RB
cord-276456-oa6hh7ky	85	14	proposed	propose	VBD
cord-276456-oa6hh7ky	85	15	for	for	IN
cord-276456-oa6hh7ky	85	16	synaptotagmin	synaptotagmin	JJ
cord-276456-oa6hh7ky	85	17	-	-	HYPH
cord-276456-oa6hh7ky	85	18	syntaxin	syntaxin	JJ
cord-276456-oa6hh7ky	85	19	interaction	interaction	NN
cord-276456-oa6hh7ky	85	20	,	,	,
cord-276456-oa6hh7ky	85	21	but	but	CC
cord-276456-oa6hh7ky	85	22	better	well	RBR
cord-276456-oa6hh7ky	85	23	suited	suited	JJ
cord-276456-oa6hh7ky	85	24	to	to	IN
cord-276456-oa6hh7ky	85	25	instantaneously	instantaneously	RB
cord-276456-oa6hh7ky	85	26	stressing	stress	VBG
cord-276456-oa6hh7ky	85	27	the	the	DT
cord-276456-oa6hh7ky	85	28	phospholipid	phospholipid	NN
cord-276456-oa6hh7ky	85	29	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	85	30	of	of	IN
cord-276456-oa6hh7ky	85	31	the	the	DT
cord-276456-oa6hh7ky	85	32	presynaptic	presynaptic	JJ
cord-276456-oa6hh7ky	85	33	membrane	membrane	NN
cord-276456-oa6hh7ky	85	34	and	and	CC
cord-276456-oa6hh7ky	85	35	the	the	DT
cord-276456-oa6hh7ky	85	36	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	85	37	vesicle	vesicle	NN
cord-276456-oa6hh7ky	85	38	for	for	IN
cord-276456-oa6hh7ky	85	39	the	the	DT
cord-276456-oa6hh7ky	85	40	ultra	ultra	JJ
cord-276456-oa6hh7ky	85	41	-	-	JJ
cord-276456-oa6hh7ky	85	42	rapid	rapid	JJ
cord-276456-oa6hh7ky	85	43	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	85	44	seen	see	VBN
cord-276456-oa6hh7ky	85	45	in	in	IN
cord-276456-oa6hh7ky	85	46	the	the	DT
cord-276456-oa6hh7ky	85	47	nervous	nervous	JJ
cord-276456-oa6hh7ky	85	48	system	system	NN
cord-276456-oa6hh7ky	85	49	.	.	.
cord-276456-oa6hh7ky	86	1	Second	second	RB
cord-276456-oa6hh7ky	86	2	,	,	,
cord-276456-oa6hh7ky	86	3	even	even	RB
cord-276456-oa6hh7ky	86	4	without	without	IN
cord-276456-oa6hh7ky	86	5	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	86	6	,	,	,
cord-276456-oa6hh7ky	86	7	Ca	Ca	NNP
cord-276456-oa6hh7ky	86	8	2	2	CD
cord-276456-oa6hh7ky	86	9	þ	þ	NNP
cord-276456-oa6hh7ky	86	10	speeds	speed	VBZ
cord-276456-oa6hh7ky	86	11	up	up	RP
cord-276456-oa6hh7ky	86	12	fusion	fusion	NN
cord-276456-oa6hh7ky	86	13	of	of	IN
cord-276456-oa6hh7ky	86	14	SNARE	snare	NN
cord-276456-oa6hh7ky	86	15	-	-	HYPH
cord-276456-oa6hh7ky	86	16	reconstituted	reconstitute	VBN
cord-276456-oa6hh7ky	86	17	membranes	membrane	NNS
cord-276456-oa6hh7ky	86	18	considerably	considerably	RB
cord-276456-oa6hh7ky	86	19	.	.	.
cord-276456-oa6hh7ky	87	1	Perhaps	perhaps	RB
cord-276456-oa6hh7ky	87	2	divalent	divalent	JJ
cord-276456-oa6hh7ky	87	3	ions	ion	NNS
cord-276456-oa6hh7ky	87	4	play	play	VBP
cord-276456-oa6hh7ky	87	5	a	a	DT
cord-276456-oa6hh7ky	87	6	direct	direct	JJ
cord-276456-oa6hh7ky	87	7	role	role	NN
cord-276456-oa6hh7ky	87	8	,	,	,
cord-276456-oa6hh7ky	87	9	electrostatically	electrostatically	RB
cord-276456-oa6hh7ky	87	10	complexing	complexe	VBG
cord-276456-oa6hh7ky	87	11	PS	PS	NNP
cord-276456-oa6hh7ky	87	12	headgroups	headgroups	NNP
cord-276456-oa6hh7ky	87	13	to	to	TO
cord-276456-oa6hh7ky	87	14	promote	promote	VB
cord-276456-oa6hh7ky	87	15	fusion	fusion	NN
cord-276456-oa6hh7ky	87	16	between	between	IN
cord-276456-oa6hh7ky	87	17	negatively	negatively	RB
cord-276456-oa6hh7ky	87	18	charged	charge	VBN
cord-276456-oa6hh7ky	87	19	phospholipid	phospholipid	NN
cord-276456-oa6hh7ky	87	20	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	87	21	.	.	.
cord-276456-oa6hh7ky	88	1	Is	be	VBZ
cord-276456-oa6hh7ky	88	2	this	this	DT
cord-276456-oa6hh7ky	88	3	effect	effect	NN
cord-276456-oa6hh7ky	88	4	specific	specific	JJ
cord-276456-oa6hh7ky	88	5	for	for	IN
cord-276456-oa6hh7ky	88	6	calcium	calcium	NN
cord-276456-oa6hh7ky	88	7	over	over	IN
cord-276456-oa6hh7ky	88	8	magnesium	magnesium	NN
cord-276456-oa6hh7ky	88	9	?	?	.
cord-276456-oa6hh7ky	89	1	There	there	EX
cord-276456-oa6hh7ky	89	2	are	be	VBP
cord-276456-oa6hh7ky	89	3	indications	indication	NNS
cord-276456-oa6hh7ky	89	4	that	that	IN
cord-276456-oa6hh7ky	89	5	the	the	DT
cord-276456-oa6hh7ky	89	6	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	89	7	curvature	curvature	NN
cord-276456-oa6hh7ky	89	8	of	of	IN
cord-276456-oa6hh7ky	89	9	PS	PS	NNP
cord-276456-oa6hh7ky	89	10	in	in	IN
cord-276456-oa6hh7ky	89	11	the	the	DT
cord-276456-oa6hh7ky	89	12	presence	presence	NN
cord-276456-oa6hh7ky	89	13	of	of	IN
cord-276456-oa6hh7ky	89	14	calcium	calcium	NN
cord-276456-oa6hh7ky	89	15	,	,	,
cord-276456-oa6hh7ky	89	16	but	but	CC
cord-276456-oa6hh7ky	89	17	not	not	RB
cord-276456-oa6hh7ky	89	18	magnesium	magnesium	NN
cord-276456-oa6hh7ky	89	19	,	,	,
cord-276456-oa6hh7ky	89	20	is	be	VBZ
cord-276456-oa6hh7ky	89	21	significantly	significantly	RB
cord-276456-oa6hh7ky	89	22	more	more	RBR
cord-276456-oa6hh7ky	89	23	negative	negative	JJ
cord-276456-oa6hh7ky	89	24	with	with	IN
cord-276456-oa6hh7ky	89	25	calcium	calcium	NN
cord-276456-oa6hh7ky	89	26	than	than	IN
cord-276456-oa6hh7ky	89	27	with	with	IN
cord-276456-oa6hh7ky	89	28	magnesium	magnesium	NN
cord-276456-oa6hh7ky	89	29	.	.	.
cord-276456-oa6hh7ky	90	1	2	2	LS
cord-276456-oa6hh7ky	91	1	Ultimately	ultimately	RB
cord-276456-oa6hh7ky	91	2	,	,	,
cord-276456-oa6hh7ky	91	3	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	91	4	,	,	,
cord-276456-oa6hh7ky	91	5	SNAREs	SNAREs	NNP
cord-276456-oa6hh7ky	91	6	,	,	,
cord-276456-oa6hh7ky	91	7	and	and	CC
cord-276456-oa6hh7ky	91	8	the	the	DT
cord-276456-oa6hh7ky	91	9	other	other	JJ
cord-276456-oa6hh7ky	91	10	proteins	protein	NNS
cord-276456-oa6hh7ky	91	11	that	that	WDT
cord-276456-oa6hh7ky	91	12	comprise	comprise	VBP
cord-276456-oa6hh7ky	91	13	the	the	DT
cord-276456-oa6hh7ky	91	14	exocytotic	exocytotic	JJ
cord-276456-oa6hh7ky	91	15	fusion	fusion	NN
cord-276456-oa6hh7ky	91	16	machine	machine	NN
cord-276456-oa6hh7ky	91	17	must	must	MD
cord-276456-oa6hh7ky	91	18	cajole	cajole	VB
cord-276456-oa6hh7ky	91	19	lipids	lipid	NNS
cord-276456-oa6hh7ky	91	20	to	to	TO
cord-276456-oa6hh7ky	91	21	move	move	VB
cord-276456-oa6hh7ky	91	22	through	through	IN
cord-276456-oa6hh7ky	91	23	a	a	DT
cord-276456-oa6hh7ky	91	24	pathway	pathway	NN
cord-276456-oa6hh7ky	91	25	that	that	WDT
cord-276456-oa6hh7ky	91	26	culminates	culminate	VBZ
cord-276456-oa6hh7ky	91	27	in	in	IN
cord-276456-oa6hh7ky	91	28	fusion	fusion	NN
cord-276456-oa6hh7ky	91	29	pore	pore	NN
cord-276456-oa6hh7ky	91	30	opening	opening	NN
cord-276456-oa6hh7ky	91	31	.	.	.
cord-276456-oa6hh7ky	92	1	The	the	DT
cord-276456-oa6hh7ky	92	2	SNARE	snare	NN
cord-276456-oa6hh7ky	92	3	proteins	protein	NNS
cord-276456-oa6hh7ky	92	4	and	and	CC
cord-276456-oa6hh7ky	92	5	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	92	6	are	be	VBP
cord-276456-oa6hh7ky	92	7	the	the	DT
cord-276456-oa6hh7ky	92	8	guides	guide	NNS
cord-276456-oa6hh7ky	92	9	that	that	WDT
cord-276456-oa6hh7ky	92	10	walk	walk	VBP
cord-276456-oa6hh7ky	92	11	and	and	CC
cord-276456-oa6hh7ky	92	12	pull	pull	VB
cord-276456-oa6hh7ky	92	13	the	the	DT
cord-276456-oa6hh7ky	92	14	membrane	membrane	NN
cord-276456-oa6hh7ky	92	15	through	through	IN
cord-276456-oa6hh7ky	92	16	a	a	DT
cord-276456-oa6hh7ky	92	17	bumpy	bumpy	JJ
cord-276456-oa6hh7ky	92	18	stalk	stalk	NN
cord-276456-oa6hh7ky	92	19	-	-	HYPH
cord-276456-oa6hh7ky	92	20	pore	pore	NN
cord-276456-oa6hh7ky	92	21	path	path	NN
cord-276456-oa6hh7ky	92	22	,	,	,
cord-276456-oa6hh7ky	92	23	with	with	IN
cord-276456-oa6hh7ky	92	24	electrostatic	electrostatic	JJ
cord-276456-oa6hh7ky	92	25	interactions	interaction	NNS
cord-276456-oa6hh7ky	92	26	playing	play	VBG
cord-276456-oa6hh7ky	92	27	a	a	DT
cord-276456-oa6hh7ky	92	28	larger	large	JJR
cord-276456-oa6hh7ky	92	29	role	role	NN
cord-276456-oa6hh7ky	92	30	than	than	IN
cord-276456-oa6hh7ky	92	31	hitherto	hitherto	VBD
cord-276456-oa6hh7ky	92	32	realized	realize	VBN
cord-276456-oa6hh7ky	92	33	.	.	.
cord-276456-oa6hh7ky	93	1	20	20	CD
cord-276456-oa6hh7ky	93	2	5.14.5	5.14.5	CD
cord-276456-oa6hh7ky	94	1	Why	why	WRB
cord-276456-oa6hh7ky	94	2	Is	be	VBZ
cord-276456-oa6hh7ky	94	3	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	94	4	2	2	CD
cord-276456-oa6hh7ky	94	5	Needed	Needed	NNP
cord-276456-oa6hh7ky	94	6	for	for	IN
cord-276456-oa6hh7ky	94	7	Exocytotic	Exocytotic	NNP
cord-276456-oa6hh7ky	94	8	Fusion	Fusion	NNP
cord-276456-oa6hh7ky	94	9	?	?	.
cord-276456-oa6hh7ky	95	1	Experiments	experiment	NNS
cord-276456-oa6hh7ky	95	2	on	on	IN
cord-276456-oa6hh7ky	95	3	the	the	DT
cord-276456-oa6hh7ky	95	4	permeabilized	permeabilized	NNP
cord-276456-oa6hh7ky	95	5	chromaffin	chromaffin	NNP
cord-276456-oa6hh7ky	95	6	cell	cell	NN
cord-276456-oa6hh7ky	95	7	established	establish	VBD
cord-276456-oa6hh7ky	95	8	a	a	DT
cord-276456-oa6hh7ky	95	9	requirement	requirement	NN
cord-276456-oa6hh7ky	95	10	for	for	IN
cord-276456-oa6hh7ky	95	11	ATP	ATP	NNP
cord-276456-oa6hh7ky	95	12	in	in	IN
cord-276456-oa6hh7ky	95	13	membrane	membrane	NN
cord-276456-oa6hh7ky	95	14	fusion	fusion	NN
cord-276456-oa6hh7ky	95	15	in	in	IN
cord-276456-oa6hh7ky	95	16	exocytotic	exocytotic	JJ
cord-276456-oa6hh7ky	95	17	secretion	secretion	NN
cord-276456-oa6hh7ky	95	18	.	.	.
cord-276456-oa6hh7ky	96	1	30	30	CD
cord-276456-oa6hh7ky	96	2	,	,	,
cord-276456-oa6hh7ky	96	3	31	31	CD
cord-276456-oa6hh7ky	97	1	Further	further	JJ
cord-276456-oa6hh7ky	97	2	work	work	NN
cord-276456-oa6hh7ky	97	3	revealed	reveal	VBD
cord-276456-oa6hh7ky	97	4	the	the	DT
cord-276456-oa6hh7ky	97	5	product	product	NN
cord-276456-oa6hh7ky	97	6	of	of	IN
cord-276456-oa6hh7ky	97	7	ATP	ATP	NNP
cord-276456-oa6hh7ky	97	8	in	in	IN
cord-276456-oa6hh7ky	97	9	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	97	10	to	to	TO
cord-276456-oa6hh7ky	97	11	be	be	VB
cord-276456-oa6hh7ky	97	12	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	97	13	2	2	CD
cord-276456-oa6hh7ky	97	14	,	,	,
cord-276456-oa6hh7ky	97	15	which	which	WDT
cord-276456-oa6hh7ky	97	16	stands	stand	VBZ
cord-276456-oa6hh7ky	97	17	out	out	RP
cord-276456-oa6hh7ky	97	18	as	as	IN
cord-276456-oa6hh7ky	97	19	a	a	DT
cord-276456-oa6hh7ky	97	20	key	key	JJ
cord-276456-oa6hh7ky	97	21	player	player	NN
cord-276456-oa6hh7ky	97	22	amongst	amongst	IN
cord-276456-oa6hh7ky	97	23	bilayer	bilayer	JJ
cord-276456-oa6hh7ky	97	24	lipids	lipid	NNS
cord-276456-oa6hh7ky	97	25	.	.	.
cord-276456-oa6hh7ky	98	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	98	2	has	have	VBZ
cord-276456-oa6hh7ky	98	3	been	be	VBN
cord-276456-oa6hh7ky	98	4	almost	almost	RB
cord-276456-oa6hh7ky	98	5	20	20	CD
cord-276456-oa6hh7ky	98	6	years	year	NNS
cord-276456-oa6hh7ky	98	7	since	since	IN
cord-276456-oa6hh7ky	98	8	this	this	DT
cord-276456-oa6hh7ky	98	9	minor	minor	JJ
cord-276456-oa6hh7ky	98	10	plasma	plasma	NN
cord-276456-oa6hh7ky	98	11	membrane	membrane	NN
cord-276456-oa6hh7ky	98	12	constituent	constituent	NN
cord-276456-oa6hh7ky	98	13	was	be	VBD
cord-276456-oa6hh7ky	98	14	directly	directly	RB
cord-276456-oa6hh7ky	98	15	implicated	implicate	VBN
cord-276456-oa6hh7ky	98	16	in	in	IN
cord-276456-oa6hh7ky	98	17	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	98	18	.	.	.
cord-276456-oa6hh7ky	99	1	The	the	DT
cord-276456-oa6hh7ky	99	2	early	early	JJ
cord-276456-oa6hh7ky	99	3	studies	study	NNS
cord-276456-oa6hh7ky	99	4	used	use	VBD
cord-276456-oa6hh7ky	99	5	biochemical	biochemical	JJ
cord-276456-oa6hh7ky	99	6	approaches	approach	NNS
cord-276456-oa6hh7ky	99	7	in	in	IN
cord-276456-oa6hh7ky	99	8	permeabilized	permeabilized	JJ
cord-276456-oa6hh7ky	99	9	cells	cell	NNS
cord-276456-oa6hh7ky	99	10	that	that	WDT
cord-276456-oa6hh7ky	99	11	directly	directly	RB
cord-276456-oa6hh7ky	99	12	implicated	implicate	VBD
cord-276456-oa6hh7ky	99	13	the	the	DT
cord-276456-oa6hh7ky	99	14	polyphosphoinositides	polyphosphoinositide	NNS
cord-276456-oa6hh7ky	99	15	30	30	CD
cord-276456-oa6hh7ky	99	16	and	and	CC
cord-276456-oa6hh7ky	99	17	subsequently	subsequently	RB
cord-276456-oa6hh7ky	99	18	PIP	PIP	NNP
cord-276456-oa6hh7ky	99	19	kinase	kinase	NN
cord-276456-oa6hh7ky	99	20	and	and	CC
cord-276456-oa6hh7ky	99	21	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	99	22	2	2	CD
cord-276456-oa6hh7ky	99	23	5	5	CD
cord-276456-oa6hh7ky	99	24	as	as	IN
cord-276456-oa6hh7ky	99	25	key	key	JJ
cord-276456-oa6hh7ky	99	26	components	component	NNS
cord-276456-oa6hh7ky	99	27	late	late	RB
cord-276456-oa6hh7ky	99	28	in	in	IN
cord-276456-oa6hh7ky	99	29	the	the	DT
cord-276456-oa6hh7ky	99	30	fusion	fusion	NN
cord-276456-oa6hh7ky	99	31	pathway	pathway	NN
cord-276456-oa6hh7ky	99	32	.	.	.
cord-276456-oa6hh7ky	100	1	Imaging	Imaging	NNP
cord-276456-oa6hh7ky	100	2	of	of	IN
cord-276456-oa6hh7ky	100	3	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	100	4	2	2	CD
cord-276456-oa6hh7ky	100	5	in	in	IN
cord-276456-oa6hh7ky	100	6	secreting	secrete	VBG
cord-276456-oa6hh7ky	100	7	cells	cell	NNS
cord-276456-oa6hh7ky	100	8	demonstrates	demonstrate	VBZ
cord-276456-oa6hh7ky	100	9	that	that	IN
cord-276456-oa6hh7ky	100	10	the	the	DT
cord-276456-oa6hh7ky	100	11	lipid	lipid	NN
cord-276456-oa6hh7ky	100	12	is	be	VBZ
cord-276456-oa6hh7ky	100	13	located	locate	VBN
cord-276456-oa6hh7ky	100	14	on	on	IN
cord-276456-oa6hh7ky	100	15	the	the	DT
cord-276456-oa6hh7ky	100	16	plasma	plasma	NN
cord-276456-oa6hh7ky	100	17	membrane	membrane	NN
cord-276456-oa6hh7ky	100	18	and	and	CC
cord-276456-oa6hh7ky	100	19	not	not	RB
cord-276456-oa6hh7ky	100	20	on	on	IN
cord-276456-oa6hh7ky	100	21	the	the	DT
cord-276456-oa6hh7ky	100	22	secretory	secretory	JJ
cord-276456-oa6hh7ky	100	23	granule	granule	NN
cord-276456-oa6hh7ky	100	24	.	.	.
cord-276456-oa6hh7ky	101	1	32	32	CD
cord-276456-oa6hh7ky	101	2	,	,	,
cord-276456-oa6hh7ky	101	3	33	33	CD
cord-276456-oa6hh7ky	101	4	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	101	5	2	2	CD
cord-276456-oa6hh7ky	101	6	associates	associate	NNS
cord-276456-oa6hh7ky	101	7	with	with	IN
cord-276456-oa6hh7ky	101	8	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	101	9	puncta	puncta	NN
cord-276456-oa6hh7ky	101	10	in	in	IN
cord-276456-oa6hh7ky	101	11	plasma	plasma	NN
cord-276456-oa6hh7ky	101	12	membrane	membrane	NN
cord-276456-oa6hh7ky	101	13	lawns	lawn	NNS
cord-276456-oa6hh7ky	101	14	from	from	IN
cord-276456-oa6hh7ky	101	15	PC12	pc12	JJ
cord-276456-oa6hh7ky	101	16	cells	cell	NNS
cord-276456-oa6hh7ky	101	17	.	.	.
cord-276456-oa6hh7ky	102	1	7	7	CD
cord-276456-oa6hh7ky	103	1	The	the	DT
cord-276456-oa6hh7ky	103	2	concentration	concentration	NN
cord-276456-oa6hh7ky	103	3	of	of	IN
cord-276456-oa6hh7ky	103	4	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	103	5	2	2	CD
cord-276456-oa6hh7ky	103	6	in	in	IN
cord-276456-oa6hh7ky	103	7	the	the	DT
cord-276456-oa6hh7ky	103	8	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	103	9	leaflet	leaflet	NN
cord-276456-oa6hh7ky	103	10	of	of	IN
cord-276456-oa6hh7ky	103	11	puncta	puncta	NN
cord-276456-oa6hh7ky	103	12	is	be	VBZ
cord-276456-oa6hh7ky	103	13	surprisingly	surprisingly	RB
cord-276456-oa6hh7ky	103	14	high	high	JJ
cord-276456-oa6hh7ky	103	15	,	,	,
cord-276456-oa6hh7ky	103	16	B6	b6	NN
cord-276456-oa6hh7ky	103	17	mole%	mole%	NN
cord-276456-oa6hh7ky	103	18	.	.	.
cord-276456-oa6hh7ky	104	1	8	8	CD
cord-276456-oa6hh7ky	105	1	An	an	DT
cord-276456-oa6hh7ky	105	2	initial	initial	JJ
cord-276456-oa6hh7ky	105	3	fusion	fusion	NN
cord-276456-oa6hh7ky	105	4	pore	pore	NN
cord-276456-oa6hh7ky	105	5	of	of	IN
cord-276456-oa6hh7ky	105	6	3	3	CD
cord-276456-oa6hh7ky	105	7	nm	nm	NN
cord-276456-oa6hh7ky	105	8	diameter	diameter	NN
cord-276456-oa6hh7ky	105	9	and	and	CC
cord-276456-oa6hh7ky	105	10	10	10	CD
cord-276456-oa6hh7ky	105	11	nm	nm	NN
cord-276456-oa6hh7ky	105	12	9,10	9,10	CD
cord-276456-oa6hh7ky	105	13	would	would	MD
cord-276456-oa6hh7ky	105	14	have	have	VB
cord-276456-oa6hh7ky	105	15	room	room	NN
cord-276456-oa6hh7ky	105	16	for	for	IN
cord-276456-oa6hh7ky	105	17	approximately	approximately	RB
cord-276456-oa6hh7ky	105	18	140	140	CD
cord-276456-oa6hh7ky	105	19	phospholipid	phospholipid	NN
cord-276456-oa6hh7ky	105	20	molecules	molecule	NNS
cord-276456-oa6hh7ky	105	21	(	(	-LRB-
cord-276456-oa6hh7ky	105	22	area	area	NN
cord-276456-oa6hh7ky	105	23	¼	¼	CD
cord-276456-oa6hh7ky	105	24	70	70	CD
cord-276456-oa6hh7ky	105	25	Å	å	NN
cord-276456-oa6hh7ky	105	26	2	2	CD
cord-276456-oa6hh7ky	105	27	)	)	-RRB-
cord-276456-oa6hh7ky	105	28	facing	face	VBG
cord-276456-oa6hh7ky	105	29	the	the	DT
cord-276456-oa6hh7ky	105	30	cytosol	cytosol	NN
cord-276456-oa6hh7ky	105	31	including	include	VBG
cord-276456-oa6hh7ky	105	32	nine	nine	CD
cord-276456-oa6hh7ky	105	33	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	105	34	2	2	CD
cord-276456-oa6hh7ky	105	35	molecules	molecule	NNS
cord-276456-oa6hh7ky	105	36	at	at	IN
cord-276456-oa6hh7ky	105	37	6	6	CD
cord-276456-oa6hh7ky	105	38	mole%	mole%	NN
cord-276456-oa6hh7ky	105	39	.	.	.
cord-276456-oa6hh7ky	106	1	Clearly	clearly	RB
cord-276456-oa6hh7ky	106	2	,	,	,
cord-276456-oa6hh7ky	106	3	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	106	4	2	2	CD
cord-276456-oa6hh7ky	106	5	is	be	VBZ
cord-276456-oa6hh7ky	106	6	absolutely	absolutely	RB
cord-276456-oa6hh7ky	106	7	required	require	VBN
cord-276456-oa6hh7ky	106	8	for	for	IN
cord-276456-oa6hh7ky	106	9	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	106	10	.	.	.
cord-276456-oa6hh7ky	107	1	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	107	2	2	2	CD
cord-276456-oa6hh7ky	107	3	can	can	MD
cord-276456-oa6hh7ky	107	4	have	have	VB
cord-276456-oa6hh7ky	107	5	two	two	CD
cord-276456-oa6hh7ky	107	6	,	,	,
cord-276456-oa6hh7ky	107	7	potentially	potentially	RB
cord-276456-oa6hh7ky	107	8	interrelated	interrelated	JJ
cord-276456-oa6hh7ky	107	9	functions	function	NNS
cord-276456-oa6hh7ky	107	10	:	:	:
cord-276456-oa6hh7ky	107	11	1	1	CD
cord-276456-oa6hh7ky	107	12	.	.	.
cord-276456-oa6hh7ky	108	1	As	as	IN
cord-276456-oa6hh7ky	108	2	a	a	DT
cord-276456-oa6hh7ky	108	3	scaffold	scaffold	NN
cord-276456-oa6hh7ky	108	4	for	for	IN
cord-276456-oa6hh7ky	108	5	proteins	protein	NNS
cord-276456-oa6hh7ky	108	6	of	of	IN
cord-276456-oa6hh7ky	108	7	the	the	DT
cord-276456-oa6hh7ky	108	8	exocytotic	exocytotic	JJ
cord-276456-oa6hh7ky	108	9	and	and	CC
cord-276456-oa6hh7ky	108	10	endocytotic	endocytotic	JJ
cord-276456-oa6hh7ky	108	11	pathways	pathway	NNS
cord-276456-oa6hh7ky	108	12	,	,	,
cord-276456-oa6hh7ky	108	13	such	such	JJ
cord-276456-oa6hh7ky	108	14	as	as	IN
cord-276456-oa6hh7ky	108	15	the	the	DT
cord-276456-oa6hh7ky	108	16	exocyst	exocyst	NN
cord-276456-oa6hh7ky	108	17	and	and	CC
cord-276456-oa6hh7ky	108	18	indirect	indirect	JJ
cord-276456-oa6hh7ky	108	19	effects	effect	NNS
cord-276456-oa6hh7ky	108	20	through	through	IN
cord-276456-oa6hh7ky	108	21	the	the	DT
cord-276456-oa6hh7ky	108	22	actin	actin	NN
cord-276456-oa6hh7ky	108	23	cytoskeleton	cytoskeleton	NN
cord-276456-oa6hh7ky	108	24	.	.	.
cord-276456-oa6hh7ky	109	1	34	34	CD
cord-276456-oa6hh7ky	109	2	-	-	SYM
cord-276456-oa6hh7ky	109	3	36	36	CD
cord-276456-oa6hh7ky	109	4	2	2	CD
cord-276456-oa6hh7ky	109	5	.	.	.
cord-276456-oa6hh7ky	110	1	As	as	IN
cord-276456-oa6hh7ky	110	2	a	a	DT
cord-276456-oa6hh7ky	110	3	lipid	lipid	NN
cord-276456-oa6hh7ky	110	4	involved	involve	VBN
cord-276456-oa6hh7ky	110	5	in	in	IN
cord-276456-oa6hh7ky	110	6	the	the	DT
cord-276456-oa6hh7ky	110	7	topological	topological	JJ
cord-276456-oa6hh7ky	110	8	rearrangement	rearrangement	NN
cord-276456-oa6hh7ky	110	9	of	of	IN
cord-276456-oa6hh7ky	110	10	the	the	DT
cord-276456-oa6hh7ky	110	11	plasma	plasma	NN
cord-276456-oa6hh7ky	110	12	membrane	membrane	NN
cord-276456-oa6hh7ky	110	13	during	during	IN
cord-276456-oa6hh7ky	110	14	fusion	fusion	NN
cord-276456-oa6hh7ky	110	15	and	and	CC
cord-276456-oa6hh7ky	110	16	fission	fission	NN
cord-276456-oa6hh7ky	110	17	.	.	.
cord-276456-oa6hh7ky	111	1	A	a	DT
cord-276456-oa6hh7ky	111	2	distinguishing	distinguishing	JJ
cord-276456-oa6hh7ky	111	3	feature	feature	NN
cord-276456-oa6hh7ky	111	4	of	of	IN
cord-276456-oa6hh7ky	111	5	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	111	6	2	2	CD
cord-276456-oa6hh7ky	111	7	is	be	VBZ
cord-276456-oa6hh7ky	111	8	its	-PRON-	PRP$
cord-276456-oa6hh7ky	111	9	high	high	JJ
cord-276456-oa6hh7ky	111	10	negative	negative	JJ
cord-276456-oa6hh7ky	111	11	charge	charge	NN
cord-276456-oa6hh7ky	111	12	of	of	IN
cord-276456-oa6hh7ky	111	13	B	b	NN
cord-276456-oa6hh7ky	111	14	À	à	NN
cord-276456-oa6hh7ky	111	15	4	4	CD
cord-276456-oa6hh7ky	111	16	at	at	IN
cord-276456-oa6hh7ky	111	17	pH	pH	NNP
cord-276456-oa6hh7ky	111	18	7	7	CD
cord-276456-oa6hh7ky	111	19	.	.	.
cord-276456-oa6hh7ky	112	1	11	11	CD
cord-276456-oa6hh7ky	113	1	The	the	DT
cord-276456-oa6hh7ky	113	2	highly	highly	RB
cord-276456-oa6hh7ky	113	3	charged	charge	VBN
cord-276456-oa6hh7ky	113	4	lipid	lipid	NN
cord-276456-oa6hh7ky	113	5	creates	create	VBZ
cord-276456-oa6hh7ky	113	6	a	a	DT
cord-276456-oa6hh7ky	113	7	highly	highly	RB
cord-276456-oa6hh7ky	113	8	dynamic	dynamic	JJ
cord-276456-oa6hh7ky	113	9	electrostatic	electrostatic	JJ
cord-276456-oa6hh7ky	113	10	scaffold	scaffold	NN
cord-276456-oa6hh7ky	113	11	that	that	WDT
cord-276456-oa6hh7ky	113	12	interacts	interact	VBZ
cord-276456-oa6hh7ky	113	13	with	with	IN
cord-276456-oa6hh7ky	113	14	unstructured	unstructured	JJ
cord-276456-oa6hh7ky	113	15	(	(	-LRB-
cord-276456-oa6hh7ky	113	16	e.g.	e.g.	RB
cord-276456-oa6hh7ky	113	17	,	,	,
cord-276456-oa6hh7ky	113	18	in	in	IN
cord-276456-oa6hh7ky	113	19	MARCKS	MARCKS	NNP
cord-276456-oa6hh7ky	113	20	,	,	,
cord-276456-oa6hh7ky	113	21	GAP43	GAP43	NNP
cord-276456-oa6hh7ky	113	22	)	)	-RRB-
cord-276456-oa6hh7ky	113	23	and	and	CC
cord-276456-oa6hh7ky	113	24	structured	structure	VBN
cord-276456-oa6hh7ky	113	25	(	(	-LRB-
cord-276456-oa6hh7ky	113	26	e.g.	e.g.	RB
cord-276456-oa6hh7ky	113	27	,	,	,
cord-276456-oa6hh7ky	113	28	in	in	IN
cord-276456-oa6hh7ky	113	29	PH	PH	NNP
cord-276456-oa6hh7ky	113	30	and	and	CC
cord-276456-oa6hh7ky	113	31	C2	C2	NNP
cord-276456-oa6hh7ky	113	32	domains	domain	NNS
cord-276456-oa6hh7ky	113	33	)	)	-RRB-
cord-276456-oa6hh7ky	113	34	basic	basic	JJ
cord-276456-oa6hh7ky	113	35	moieties	moiety	NNS
cord-276456-oa6hh7ky	113	36	on	on	IN
cord-276456-oa6hh7ky	113	37	a	a	DT
cord-276456-oa6hh7ky	113	38	variety	variety	NN
cord-276456-oa6hh7ky	113	39	of	of	IN
cord-276456-oa6hh7ky	113	40	proteins	protein	NNS
cord-276456-oa6hh7ky	113	41	(	(	-LRB-
cord-276456-oa6hh7ky	113	42	for	for	IN
cord-276456-oa6hh7ky	113	43	a	a	DT
cord-276456-oa6hh7ky	113	44	review	review	NN
cord-276456-oa6hh7ky	113	45	see	see	UH
cord-276456-oa6hh7ky	113	46	Ref	Ref	NNP
cord-276456-oa6hh7ky	113	47	.	.	.
cord-276456-oa6hh7ky	113	48	12	12	CD
cord-276456-oa6hh7ky	113	49	)	)	-RRB-
cord-276456-oa6hh7ky	113	50	.	.	.
cord-276456-oa6hh7ky	114	1	Unstructured	unstructured	JJ
cord-276456-oa6hh7ky	114	2	basic	basic	JJ
cord-276456-oa6hh7ky	114	3	peptides	peptide	NNS
cord-276456-oa6hh7ky	114	4	cause	cause	VBP
cord-276456-oa6hh7ky	114	5	lateral	lateral	JJ
cord-276456-oa6hh7ky	114	6	sequestration	sequestration	NN
cord-276456-oa6hh7ky	114	7	of	of	IN
cord-276456-oa6hh7ky	114	8	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	114	9	2	2	CD
cord-276456-oa6hh7ky	114	10	on	on	IN
cord-276456-oa6hh7ky	114	11	membranes	membrane	NNS
cord-276456-oa6hh7ky	114	12	in	in	IN
cord-276456-oa6hh7ky	114	13	vitro	vitro	FW
cord-276456-oa6hh7ky	114	14	containing	contain	VBG
cord-276456-oa6hh7ky	114	15	1	1	CD
cord-276456-oa6hh7ky	114	16	mole%	mole%	NN
cord-276456-oa6hh7ky	114	17	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	114	18	2	2	CD
cord-276456-oa6hh7ky	114	19	with	with	IN
cord-276456-oa6hh7ky	114	20	as	as	RB
cord-276456-oa6hh7ky	114	21	much	much	JJ
cord-276456-oa6hh7ky	114	22	as	as	IN
cord-276456-oa6hh7ky	114	23	30	30	CD
cord-276456-oa6hh7ky	114	24	mole	mole	NN
cord-276456-oa6hh7ky	114	25	%	%	NN
cord-276456-oa6hh7ky	114	26	PS	PS	NNP
cord-276456-oa6hh7ky	114	27	13	13	CD
cord-276456-oa6hh7ky	114	28	,	,	,
cord-276456-oa6hh7ky	114	29	an	an	DT
cord-276456-oa6hh7ky	114	30	effect	effect	NN
cord-276456-oa6hh7ky	114	31	that	that	WDT
cord-276456-oa6hh7ky	114	32	is	be	VBZ
cord-276456-oa6hh7ky	114	33	explained	explain	VBN
cord-276456-oa6hh7ky	114	34	by	by	IN
cord-276456-oa6hh7ky	114	35	electrostatic	electrostatic	JJ
cord-276456-oa6hh7ky	114	36	considerations	consideration	NNS
cord-276456-oa6hh7ky	114	37	.	.	.
cord-276456-oa6hh7ky	115	1	14	14	CD
cord-276456-oa6hh7ky	115	2	Several	several	JJ
cord-276456-oa6hh7ky	115	3	proteins	protein	NNS
cord-276456-oa6hh7ky	115	4	that	that	WDT
cord-276456-oa6hh7ky	115	5	play	play	VBP
cord-276456-oa6hh7ky	115	6	important	important	JJ
cord-276456-oa6hh7ky	115	7	roles	role	NNS
cord-276456-oa6hh7ky	115	8	in	in	IN
cord-276456-oa6hh7ky	115	9	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	115	10	have	have	VBP
cord-276456-oa6hh7ky	115	11	structured	structure	VBN
cord-276456-oa6hh7ky	115	12	basic	basic	JJ
cord-276456-oa6hh7ky	115	13	moieties	moiety	NNS
cord-276456-oa6hh7ky	115	14	in	in	IN
cord-276456-oa6hh7ky	115	15	C2	C2	NNP
cord-276456-oa6hh7ky	115	16	domains	domain	NNS
cord-276456-oa6hh7ky	115	17	that	that	WDT
cord-276456-oa6hh7ky	115	18	interact	interact	VBP
cord-276456-oa6hh7ky	115	19	with	with	IN
cord-276456-oa6hh7ky	115	20	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	115	21	2	2	CD
cord-276456-oa6hh7ky	115	22	including	include	VBG
cord-276456-oa6hh7ky	115	23	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	115	24	15	15	CD
cord-276456-oa6hh7ky	115	25	and	and	CC
cord-276456-oa6hh7ky	115	26	rabphilin	rabphilin	NNP
cord-276456-oa6hh7ky	115	27	.	.	.
cord-276456-oa6hh7ky	116	1	16	16	CD
cord-276456-oa6hh7ky	116	2	Stop	stop	VB
cord-276456-oa6hh7ky	116	3	-	-	HYPH
cord-276456-oa6hh7ky	116	4	flow	flow	NN
cord-276456-oa6hh7ky	116	5	techniques	technique	NNS
cord-276456-oa6hh7ky	116	6	demonstrate	demonstrate	VBP
cord-276456-oa6hh7ky	116	7	that	that	IN
cord-276456-oa6hh7ky	116	8	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	116	9	2	2	CD
cord-276456-oa6hh7ky	116	10	greatly	greatly	RB
cord-276456-oa6hh7ky	116	11	speeds	speed	VBZ
cord-276456-oa6hh7ky	116	12	the	the	DT
cord-276456-oa6hh7ky	116	13	Ca	Ca	NNP
cord-276456-oa6hh7ky	116	14	2	2	CD
cord-276456-oa6hh7ky	116	15	þ	þ	NNP
cord-276456-oa6hh7ky	116	16	-dependent	-dependent	NNP
cord-276456-oa6hh7ky	116	17	interaction	interaction	NN
cord-276456-oa6hh7ky	116	18	of	of	IN
cord-276456-oa6hh7ky	116	19	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	116	20	with	with	IN
cord-276456-oa6hh7ky	116	21	membranes	membrane	NNS
cord-276456-oa6hh7ky	116	22	in	in	IN
cord-276456-oa6hh7ky	116	23	vitro	vitro	NNP
cord-276456-oa6hh7ky	116	24	17	17	CD
cord-276456-oa6hh7ky	116	25	,	,	,
cord-276456-oa6hh7ky	116	26	suggesting	suggest	VBG
cord-276456-oa6hh7ky	116	27	that	that	IN
cord-276456-oa6hh7ky	116	28	this	this	DT
cord-276456-oa6hh7ky	116	29	interaction	interaction	NN
cord-276456-oa6hh7ky	116	30	may	may	MD
cord-276456-oa6hh7ky	116	31	have	have	VB
cord-276456-oa6hh7ky	116	32	important	important	JJ
cord-276456-oa6hh7ky	116	33	physiological	physiological	JJ
cord-276456-oa6hh7ky	116	34	consequences	consequence	NNS
cord-276456-oa6hh7ky	116	35	.	.	.
cord-276456-oa6hh7ky	117	1	In	in	IN
cord-276456-oa6hh7ky	117	2	addition	addition	NN
cord-276456-oa6hh7ky	117	3	,	,	,
cord-276456-oa6hh7ky	117	4	FRET	FRET	NNP
cord-276456-oa6hh7ky	117	5	has	have	VBZ
cord-276456-oa6hh7ky	117	6	been	be	VBN
cord-276456-oa6hh7ky	117	7	used	use	VBN
cord-276456-oa6hh7ky	117	8	to	to	TO
cord-276456-oa6hh7ky	117	9	show	show	VB
cord-276456-oa6hh7ky	117	10	that	that	IN
cord-276456-oa6hh7ky	117	11	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	117	12	2	2	CD
cord-276456-oa6hh7ky	117	13	directly	directly	RB
cord-276456-oa6hh7ky	117	14	interacts	interact	VBZ
cord-276456-oa6hh7ky	117	15	with	with	IN
cord-276456-oa6hh7ky	117	16	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	117	17	in	in	IN
cord-276456-oa6hh7ky	117	18	vitro	vitro	NNP
cord-276456-oa6hh7ky	117	19	.	.	.
cord-276456-oa6hh7ky	118	1	37	37	CD
cord-276456-oa6hh7ky	119	1	There	there	EX
cord-276456-oa6hh7ky	119	2	are	be	VBP
cord-276456-oa6hh7ky	119	3	numerous	numerous	JJ
cord-276456-oa6hh7ky	119	4	proteins	protein	NNS
cord-276456-oa6hh7ky	119	5	involved	involve	VBN
cord-276456-oa6hh7ky	119	6	in	in	IN
cord-276456-oa6hh7ky	119	7	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	119	8	and	and	CC
cord-276456-oa6hh7ky	119	9	endocytosis	endocytosis	NN
cord-276456-oa6hh7ky	119	10	that	that	WDT
cord-276456-oa6hh7ky	119	11	contain	contain	VBP
cord-276456-oa6hh7ky	119	12	a	a	DT
cord-276456-oa6hh7ky	119	13	structured	structured	JJ
cord-276456-oa6hh7ky	119	14	basic	basic	JJ
cord-276456-oa6hh7ky	119	15	sequences	sequence	NNS
cord-276456-oa6hh7ky	119	16	in	in	IN
cord-276456-oa6hh7ky	119	17	pleckstrin	pleckstrin	NNP
cord-276456-oa6hh7ky	119	18	homology	homology	NN
cord-276456-oa6hh7ky	119	19	(	(	-LRB-
cord-276456-oa6hh7ky	119	20	PH	PH	NNP
cord-276456-oa6hh7ky	119	21	)	)	-RRB-
cord-276456-oa6hh7ky	119	22	domains	domain	NNS
cord-276456-oa6hh7ky	119	23	that	that	WDT
cord-276456-oa6hh7ky	119	24	interact	interact	VBP
cord-276456-oa6hh7ky	119	25	with	with	IN
cord-276456-oa6hh7ky	119	26	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	119	27	2	2	CD
cord-276456-oa6hh7ky	119	28	.	.	.
cord-276456-oa6hh7ky	120	1	These	these	DT
cord-276456-oa6hh7ky	120	2	include	include	VBP
cord-276456-oa6hh7ky	120	3	CAPS	cap	NNS
cord-276456-oa6hh7ky	120	4	in	in	IN
cord-276456-oa6hh7ky	120	5	the	the	DT
cord-276456-oa6hh7ky	120	6	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	120	7	pathway	pathway	NN
cord-276456-oa6hh7ky	120	8	19	19	CD
cord-276456-oa6hh7ky	120	9	and	and	CC
cord-276456-oa6hh7ky	120	10	dynamin	dynamin	NNS
cord-276456-oa6hh7ky	120	11	in	in	IN
cord-276456-oa6hh7ky	120	12	the	the	DT
cord-276456-oa6hh7ky	120	13	endocytosis	endocytosis	NN
cord-276456-oa6hh7ky	120	14	pathway	pathway	NN
cord-276456-oa6hh7ky	120	15	.	.	.
cord-276456-oa6hh7ky	121	1	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	121	2	2	2	CD
cord-276456-oa6hh7ky	121	3	also	also	RB
cord-276456-oa6hh7ky	121	4	plays	play	VBZ
cord-276456-oa6hh7ky	121	5	an	an	DT
cord-276456-oa6hh7ky	121	6	important	important	JJ
cord-276456-oa6hh7ky	121	7	regulatory	regulatory	JJ
cord-276456-oa6hh7ky	121	8	role	role	NN
cord-276456-oa6hh7ky	121	9	in	in	IN
cord-276456-oa6hh7ky	121	10	conjunction	conjunction	NN
cord-276456-oa6hh7ky	121	11	with	with	IN
cord-276456-oa6hh7ky	121	12	small	small	JJ
cord-276456-oa6hh7ky	121	13	GTPases	gtpase	NNS
cord-276456-oa6hh7ky	121	14	and	and	CC
cord-276456-oa6hh7ky	121	15	proteins	protein	NNS
cord-276456-oa6hh7ky	121	16	that	that	WDT
cord-276456-oa6hh7ky	121	17	regulate	regulate	VBP
cord-276456-oa6hh7ky	121	18	the	the	DT
cord-276456-oa6hh7ky	121	19	actin	actin	NN
cord-276456-oa6hh7ky	121	20	cytoskeleton	cytoskeleton	NN
cord-276456-oa6hh7ky	121	21	.	.	.
cord-276456-oa6hh7ky	122	1	20	20	CD
cord-276456-oa6hh7ky	123	1	These	these	DT
cord-276456-oa6hh7ky	123	2	pathways	pathway	NNS
cord-276456-oa6hh7ky	123	3	also	also	RB
cord-276456-oa6hh7ky	123	4	influence	influence	VBP
cord-276456-oa6hh7ky	123	5	fusion	fusion	NN
cord-276456-oa6hh7ky	123	6	and	and	CC
cord-276456-oa6hh7ky	123	7	fission	fission	NN
cord-276456-oa6hh7ky	123	8	.	.	.
cord-276456-oa6hh7ky	124	1	While	while	IN
cord-276456-oa6hh7ky	124	2	there	there	EX
cord-276456-oa6hh7ky	124	3	is	be	VBZ
cord-276456-oa6hh7ky	124	4	strong	strong	JJ
cord-276456-oa6hh7ky	124	5	evidence	evidence	NN
cord-276456-oa6hh7ky	124	6	for	for	IN
cord-276456-oa6hh7ky	124	7	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	124	8	2	2	CD
cord-276456-oa6hh7ky	124	9	interacting	interact	VBG
cord-276456-oa6hh7ky	124	10	with	with	IN
cord-276456-oa6hh7ky	124	11	proteins	protein	NNS
cord-276456-oa6hh7ky	124	12	that	that	WDT
cord-276456-oa6hh7ky	124	13	are	be	VBP
cord-276456-oa6hh7ky	124	14	important	important	JJ
cord-276456-oa6hh7ky	124	15	for	for	IN
cord-276456-oa6hh7ky	124	16	fusion	fusion	NN
cord-276456-oa6hh7ky	124	17	and	and	CC
cord-276456-oa6hh7ky	124	18	fission	fission	NN
cord-276456-oa6hh7ky	124	19	,	,	,
cord-276456-oa6hh7ky	124	20	there	there	EX
cord-276456-oa6hh7ky	124	21	is	be	VBZ
cord-276456-oa6hh7ky	124	22	little	little	JJ
cord-276456-oa6hh7ky	124	23	direct	direct	JJ
cord-276456-oa6hh7ky	124	24	evidence	evidence	NN
cord-276456-oa6hh7ky	124	25	at	at	IN
cord-276456-oa6hh7ky	124	26	this	this	DT
cord-276456-oa6hh7ky	124	27	time	time	NN
cord-276456-oa6hh7ky	124	28	for	for	IN
cord-276456-oa6hh7ky	124	29	a	a	DT
cord-276456-oa6hh7ky	124	30	direct	direct	JJ
cord-276456-oa6hh7ky	124	31	role	role	NN
cord-276456-oa6hh7ky	124	32	of	of	IN
cord-276456-oa6hh7ky	124	33	the	the	DT
cord-276456-oa6hh7ky	124	34	lipid	lipid	NN
cord-276456-oa6hh7ky	124	35	in	in	IN
cord-276456-oa6hh7ky	124	36	the	the	DT
cord-276456-oa6hh7ky	124	37	fusion	fusion	NN
cord-276456-oa6hh7ky	124	38	or	or	CC
cord-276456-oa6hh7ky	124	39	fission	fission	NN
cord-276456-oa6hh7ky	124	40	reactions	reaction	NNS
cord-276456-oa6hh7ky	124	41	.	.	.
cord-276456-oa6hh7ky	125	1	For	for	IN
cord-276456-oa6hh7ky	125	2	example	example	NN
cord-276456-oa6hh7ky	125	3	,	,	,
cord-276456-oa6hh7ky	125	4	both	both	DT
cord-276456-oa6hh7ky	125	5	long	long	JJ
cord-276456-oa6hh7ky	125	6	term	term	NN
cord-276456-oa6hh7ky	125	7	and	and	CC
cord-276456-oa6hh7ky	125	8	acute	acute	JJ
cord-276456-oa6hh7ky	125	9	modulation	modulation	NN
cord-276456-oa6hh7ky	125	10	of	of	IN
cord-276456-oa6hh7ky	125	11	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	125	12	2	2	CD
cord-276456-oa6hh7ky	125	13	in	in	IN
cord-276456-oa6hh7ky	125	14	chromaffin	chromaffin	NNP
cord-276456-oa6hh7ky	125	15	cells	cell	NNS
cord-276456-oa6hh7ky	125	16	alter	alter	VBP
cord-276456-oa6hh7ky	125	17	the	the	DT
cord-276456-oa6hh7ky	125	18	size	size	NN
cord-276456-oa6hh7ky	125	19	of	of	IN
cord-276456-oa6hh7ky	125	20	the	the	DT
cord-276456-oa6hh7ky	125	21	releasable	releasable	JJ
cord-276456-oa6hh7ky	125	22	granule	granule	NN
cord-276456-oa6hh7ky	125	23	pools	pool	NNS
cord-276456-oa6hh7ky	125	24	but	but	CC
cord-276456-oa6hh7ky	125	25	not	not	RB
cord-276456-oa6hh7ky	125	26	the	the	DT
cord-276456-oa6hh7ky	125	27	fusion	fusion	NN
cord-276456-oa6hh7ky	125	28	kinetics	kinetic	NNS
cord-276456-oa6hh7ky	125	29	,	,	,
cord-276456-oa6hh7ky	125	30	21	21	CD
cord-276456-oa6hh7ky	125	31	consistent	consistent	JJ
cord-276456-oa6hh7ky	125	32	with	with	IN
cord-276456-oa6hh7ky	125	33	a	a	DT
cord-276456-oa6hh7ky	125	34	role	role	NN
cord-276456-oa6hh7ky	125	35	prior	prior	RB
cord-276456-oa6hh7ky	125	36	to	to	IN
cord-276456-oa6hh7ky	125	37	but	but	CC
cord-276456-oa6hh7ky	125	38	not	not	RB
cord-276456-oa6hh7ky	125	39	during	during	IN
cord-276456-oa6hh7ky	125	40	fusion	fusion	NN
cord-276456-oa6hh7ky	125	41	.	.	.
cord-276456-oa6hh7ky	126	1	Nevertheless	nevertheless	RB
cord-276456-oa6hh7ky	126	2	,	,	,
cord-276456-oa6hh7ky	126	3	it	-PRON-	PRP
cord-276456-oa6hh7ky	126	4	seems	seem	VBZ
cord-276456-oa6hh7ky	126	5	likely	likely	JJ
cord-276456-oa6hh7ky	126	6	that	that	IN
cord-276456-oa6hh7ky	126	7	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	126	8	2	2	CD
cord-276456-oa6hh7ky	126	9	molecules	molecule	NNS
cord-276456-oa6hh7ky	126	10	with	with	IN
cord-276456-oa6hh7ky	126	11	high	high	JJ
cord-276456-oa6hh7ky	126	12	charge	charge	NN
cord-276456-oa6hh7ky	126	13	and	and	CC
cord-276456-oa6hh7ky	126	14	relatively	relatively	RB
cord-276456-oa6hh7ky	126	15	high	high	JJ
cord-276456-oa6hh7ky	126	16	concentrations	concentration	NNS
cord-276456-oa6hh7ky	126	17	at	at	IN
cord-276456-oa6hh7ky	126	18	fusion	fusion	NN
cord-276456-oa6hh7ky	126	19	sites	site	NNS
cord-276456-oa6hh7ky	126	20	(	(	-LRB-
cord-276456-oa6hh7ky	126	21	as	as	RB
cord-276456-oa6hh7ky	126	22	many	many	JJ
cord-276456-oa6hh7ky	126	23	as	as	IN
cord-276456-oa6hh7ky	126	24	nine	nine	CD
cord-276456-oa6hh7ky	126	25	molecules	molecule	NNS
cord-276456-oa6hh7ky	126	26	in	in	IN
cord-276456-oa6hh7ky	126	27	the	the	DT
cord-276456-oa6hh7ky	126	28	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	126	29	leaflet	leaflet	NN
cord-276456-oa6hh7ky	126	30	of	of	IN
cord-276456-oa6hh7ky	126	31	the	the	DT
cord-276456-oa6hh7ky	126	32	fusion	fusion	NN
cord-276456-oa6hh7ky	126	33	pore	pore	NN
cord-276456-oa6hh7ky	126	34	)	)	-RRB-
cord-276456-oa6hh7ky	126	35	would	would	MD
cord-276456-oa6hh7ky	126	36	directly	directly	RB
cord-276456-oa6hh7ky	126	37	influence	influence	VB
cord-276456-oa6hh7ky	126	38	lipid	lipid	NN
cord-276456-oa6hh7ky	126	39	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	126	40	.	.	.
cord-276456-oa6hh7ky	127	1	This	this	DT
cord-276456-oa6hh7ky	127	2	is	be	VBZ
cord-276456-oa6hh7ky	127	3	an	an	DT
cord-276456-oa6hh7ky	127	4	important	important	JJ
cord-276456-oa6hh7ky	127	5	area	area	NN
cord-276456-oa6hh7ky	127	6	for	for	IN
cord-276456-oa6hh7ky	127	7	future	future	JJ
cord-276456-oa6hh7ky	127	8	investigation	investigation	NN
cord-276456-oa6hh7ky	127	9	.	.	.
cord-276456-oa6hh7ky	128	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	128	2	will	will	MD
cord-276456-oa6hh7ky	128	3	be	be	VB
cord-276456-oa6hh7ky	128	4	challenging	challenge	VBG
cord-276456-oa6hh7ky	128	5	to	to	TO
cord-276456-oa6hh7ky	128	6	distinguish	distinguish	VB
cord-276456-oa6hh7ky	128	7	between	between	IN
cord-276456-oa6hh7ky	128	8	the	the	DT
cord-276456-oa6hh7ky	128	9	lipid	lipid	NN
cord-276456-oa6hh7ky	128	10	simply	simply	RB
cord-276456-oa6hh7ky	128	11	being	be	VBG
cord-276456-oa6hh7ky	128	12	a	a	DT
cord-276456-oa6hh7ky	128	13	scaffold	scaffold	NN
cord-276456-oa6hh7ky	128	14	for	for	IN
cord-276456-oa6hh7ky	128	15	a	a	DT
cord-276456-oa6hh7ky	128	16	multitude	multitude	NN
cord-276456-oa6hh7ky	128	17	of	of	IN
cord-276456-oa6hh7ky	128	18	proteins	protein	NNS
cord-276456-oa6hh7ky	128	19	involved	involve	VBN
cord-276456-oa6hh7ky	128	20	with	with	IN
cord-276456-oa6hh7ky	128	21	trafficking	trafficking	NN
cord-276456-oa6hh7ky	128	22	at	at	IN
cord-276456-oa6hh7ky	128	23	the	the	DT
cord-276456-oa6hh7ky	128	24	plasma	plasma	NN
cord-276456-oa6hh7ky	128	25	membrane	membrane	NN
cord-276456-oa6hh7ky	128	26	,	,	,
cord-276456-oa6hh7ky	128	27	and	and	CC
cord-276456-oa6hh7ky	128	28	having	have	VBG
cord-276456-oa6hh7ky	128	29	a	a	DT
cord-276456-oa6hh7ky	128	30	direct	direct	JJ
cord-276456-oa6hh7ky	128	31	function	function	NN
cord-276456-oa6hh7ky	128	32	in	in	IN
cord-276456-oa6hh7ky	128	33	the	the	DT
cord-276456-oa6hh7ky	128	34	bilayer	bilayer	NN
cord-276456-oa6hh7ky	128	35	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	128	36	of	of	IN
cord-276456-oa6hh7ky	128	37	fusion	fusion	NN
cord-276456-oa6hh7ky	128	38	and	and	CC
cord-276456-oa6hh7ky	128	39	fission	fission	NN
cord-276456-oa6hh7ky	128	40	.	.	.
cord-276456-oa6hh7ky	129	1	In	in	IN
cord-276456-oa6hh7ky	129	2	fact	fact	NN
cord-276456-oa6hh7ky	129	3	,	,	,
cord-276456-oa6hh7ky	129	4	these	these	DT
cord-276456-oa6hh7ky	129	5	two	two	CD
cord-276456-oa6hh7ky	129	6	roles	role	NNS
cord-276456-oa6hh7ky	129	7	may	may	MD
cord-276456-oa6hh7ky	129	8	sometimes	sometimes	RB
cord-276456-oa6hh7ky	129	9	be	be	VB
cord-276456-oa6hh7ky	129	10	indistinguishable	indistinguishable	JJ
cord-276456-oa6hh7ky	129	11	,	,	,
cord-276456-oa6hh7ky	129	12	since	since	IN
cord-276456-oa6hh7ky	129	13	one	one	CD
cord-276456-oa6hh7ky	129	14	or	or	CC
cord-276456-oa6hh7ky	129	15	more	more	JJR
cord-276456-oa6hh7ky	129	16	of	of	IN
cord-276456-oa6hh7ky	129	17	the	the	DT
cord-276456-oa6hh7ky	129	18	interacting	interact	VBG
cord-276456-oa6hh7ky	129	19	proteins	protein	NNS
cord-276456-oa6hh7ky	129	20	may	may	MD
cord-276456-oa6hh7ky	129	21	have	have	VB
cord-276456-oa6hh7ky	129	22	as	as	IN
cord-276456-oa6hh7ky	129	23	its	-PRON-	PRP$
cord-276456-oa6hh7ky	129	24	primary	primary	JJ
cord-276456-oa6hh7ky	129	25	task	task	NN
cord-276456-oa6hh7ky	129	26	the	the	DT
cord-276456-oa6hh7ky	129	27	regulation	regulation	NN
cord-276456-oa6hh7ky	129	28	of	of	IN
cord-276456-oa6hh7ky	129	29	PtdIns-4,5-P	PtdIns-4,5-P	NNP
cord-276456-oa6hh7ky	129	30	2	2	CD
cord-276456-oa6hh7ky	129	31	function	function	NN
cord-276456-oa6hh7ky	129	32	in	in	IN
cord-276456-oa6hh7ky	129	33	fusion	fusion	NN
cord-276456-oa6hh7ky	129	34	or	or	CC
cord-276456-oa6hh7ky	129	35	fission	fission	NN
cord-276456-oa6hh7ky	129	36	.	.	.
cord-276456-oa6hh7ky	130	1	The	the	DT
cord-276456-oa6hh7ky	130	2	superficially	superficially	RB
cord-276456-oa6hh7ky	130	3	shared	share	VBN
cord-276456-oa6hh7ky	130	4	structural	structural	JJ
cord-276456-oa6hh7ky	130	5	features	feature	NNS
cord-276456-oa6hh7ky	130	6	of	of	IN
cord-276456-oa6hh7ky	130	7	HA	HA	NNP
cord-276456-oa6hh7ky	130	8	with	with	IN
cord-276456-oa6hh7ky	130	9	the	the	DT
cord-276456-oa6hh7ky	130	10	SNARE	snare	NN
cord-276456-oa6hh7ky	130	11	proteins	protein	NNS
cord-276456-oa6hh7ky	130	12	essential	essential	JJ
cord-276456-oa6hh7ky	130	13	for	for	IN
cord-276456-oa6hh7ky	130	14	internal	internal	JJ
cord-276456-oa6hh7ky	130	15	cellular	cellular	JJ
cord-276456-oa6hh7ky	130	16	fusion	fusion	NN
cord-276456-oa6hh7ky	130	17	have	have	VBP
cord-276456-oa6hh7ky	130	18	stimulated	stimulate	VBN
cord-276456-oa6hh7ky	130	19	the	the	DT
cord-276456-oa6hh7ky	130	20	hope	hope	NN
cord-276456-oa6hh7ky	130	21	that	that	IN
cord-276456-oa6hh7ky	130	22	there	there	EX
cord-276456-oa6hh7ky	130	23	is	be	VBZ
cord-276456-oa6hh7ky	130	24	a	a	DT
cord-276456-oa6hh7ky	130	25	universal	universal	JJ
cord-276456-oa6hh7ky	130	26	mechanism	mechanism	NN
cord-276456-oa6hh7ky	130	27	for	for	IN
cord-276456-oa6hh7ky	130	28	protein	protein	NN
cord-276456-oa6hh7ky	130	29	-	-	HYPH
cord-276456-oa6hh7ky	130	30	mediated	mediate	VBN
cord-276456-oa6hh7ky	130	31	fusion	fusion	NN
cord-276456-oa6hh7ky	130	32	.	.	.
cord-276456-oa6hh7ky	131	1	As	as	IN
cord-276456-oa6hh7ky	131	2	the	the	DT
cord-276456-oa6hh7ky	131	3	prototype	prototype	NN
cord-276456-oa6hh7ky	131	4	of	of	IN
cord-276456-oa6hh7ky	131	5	class	class	NN
cord-276456-oa6hh7ky	131	6	I	-PRON-	PRP
cord-276456-oa6hh7ky	131	7	fusion	fusion	NN
cord-276456-oa6hh7ky	131	8	proteins	protein	NNS
cord-276456-oa6hh7ky	131	9	,	,	,
cord-276456-oa6hh7ky	131	10	and	and	CC
cord-276456-oa6hh7ky	131	11	the	the	DT
cord-276456-oa6hh7ky	131	12	epitope	epitope	NN
cord-276456-oa6hh7ky	131	13	for	for	IN
cord-276456-oa6hh7ky	131	14	flu	flu	NN
cord-276456-oa6hh7ky	131	15	serotyping	serotype	VBG
cord-276456-oa6hh7ky	131	16	the	the	DT
cord-276456-oa6hh7ky	131	17	influenza	influenza	NN
cord-276456-oa6hh7ky	131	18	virus	virus	NN
cord-276456-oa6hh7ky	131	19	HA	HA	NNP
cord-276456-oa6hh7ky	131	20	has	have	VBZ
cord-276456-oa6hh7ky	131	21	been	be	VBN
cord-276456-oa6hh7ky	131	22	studied	study	VBN
cord-276456-oa6hh7ky	131	23	extensively	extensively	RB
cord-276456-oa6hh7ky	131	24	.	.	.
cord-276456-oa6hh7ky	132	1	While	while	IN
cord-276456-oa6hh7ky	132	2	the	the	DT
cord-276456-oa6hh7ky	132	3	speed	speed	NN
cord-276456-oa6hh7ky	132	4	of	of	IN
cord-276456-oa6hh7ky	132	5	lipid	lipid	NN
cord-276456-oa6hh7ky	132	6	mixing	mixing	NN
cord-276456-oa6hh7ky	132	7	of	of	IN
cord-276456-oa6hh7ky	132	8	HA	HA	NNP
cord-276456-oa6hh7ky	132	9	-	-	HYPH
cord-276456-oa6hh7ky	132	10	mediated	mediate	VBN
cord-276456-oa6hh7ky	132	11	fusion	fusion	NN
cord-276456-oa6hh7ky	132	12	is	be	VBZ
cord-276456-oa6hh7ky	132	13	rapid	rapid	JJ
cord-276456-oa6hh7ky	132	14	in	in	IN
cord-276456-oa6hh7ky	132	15	vitro	vitro	FW
cord-276456-oa6hh7ky	132	16	relative	relative	JJ
cord-276456-oa6hh7ky	132	17	to	to	IN
cord-276456-oa6hh7ky	132	18	infection	infection	NN
cord-276456-oa6hh7ky	132	19	speeds	speed	NNS
cord-276456-oa6hh7ky	132	20	(	(	-LRB-
cord-276456-oa6hh7ky	132	21	Figure	figure	NN
cord-276456-oa6hh7ky	132	22	2	2	CD
cord-276456-oa6hh7ky	132	23	)	)	-RRB-
cord-276456-oa6hh7ky	132	24	,	,	,
cord-276456-oa6hh7ky	132	25	fusion	fusion	NN
cord-276456-oa6hh7ky	132	26	pore	pore	NN
cord-276456-oa6hh7ky	132	27	formation	formation	NN
cord-276456-oa6hh7ky	132	28	has	have	VBZ
cord-276456-oa6hh7ky	132	29	not	not	RB
cord-276456-oa6hh7ky	132	30	been	be	VBN
cord-276456-oa6hh7ky	132	31	measured	measure	VBN
cord-276456-oa6hh7ky	132	32	and	and	CC
cord-276456-oa6hh7ky	132	33	thus	thus	RB
cord-276456-oa6hh7ky	132	34	we	-PRON-	PRP
cord-276456-oa6hh7ky	132	35	do	do	VBP
cord-276456-oa6hh7ky	132	36	not	not	RB
cord-276456-oa6hh7ky	132	37	know	know	VB
cord-276456-oa6hh7ky	132	38	the	the	DT
cord-276456-oa6hh7ky	132	39	kinetics	kinetic	NNS
cord-276456-oa6hh7ky	132	40	of	of	IN
cord-276456-oa6hh7ky	132	41	complete	complete	JJ
cord-276456-oa6hh7ky	132	42	fusion	fusion	NN
cord-276456-oa6hh7ky	132	43	for	for	IN
cord-276456-oa6hh7ky	132	44	HA	HA	NNP
cord-276456-oa6hh7ky	132	45	in	in	IN
cord-276456-oa6hh7ky	132	46	an	an	DT
cord-276456-oa6hh7ky	132	47	intact	intact	JJ
cord-276456-oa6hh7ky	132	48	virus	virus	NN
cord-276456-oa6hh7ky	132	49	.	.	.
cord-276456-oa6hh7ky	133	1	However	however	RB
cord-276456-oa6hh7ky	133	2	,	,	,
cord-276456-oa6hh7ky	133	3	the	the	DT
cord-276456-oa6hh7ky	133	4	accessibility	accessibility	NN
cord-276456-oa6hh7ky	133	5	of	of	IN
cord-276456-oa6hh7ky	133	6	HA	HA	NNP
cord-276456-oa6hh7ky	133	7	-	-	HYPH
cord-276456-oa6hh7ky	133	8	mediated	mediate	VBN
cord-276456-oa6hh7ky	133	9	cell	cell	NN
cord-276456-oa6hh7ky	133	10	-	-	HYPH
cord-276456-oa6hh7ky	133	11	cell	cell	NN
cord-276456-oa6hh7ky	133	12	fusion	fusion	NN
cord-276456-oa6hh7ky	133	13	,	,	,
cord-276456-oa6hh7ky	133	14	and	and	CC
cord-276456-oa6hh7ky	133	15	the	the	DT
cord-276456-oa6hh7ky	133	16	large	large	JJ
cord-276456-oa6hh7ky	133	17	body	body	NN
cord-276456-oa6hh7ky	133	18	of	of	IN
cord-276456-oa6hh7ky	133	19	investigation	investigation	NN
cord-276456-oa6hh7ky	133	20	into	into	IN
cord-276456-oa6hh7ky	133	21	HA	HA	NNP
cord-276456-oa6hh7ky	133	22	make	make	VB
cord-276456-oa6hh7ky	133	23	this	this	DT
cord-276456-oa6hh7ky	133	24	the	the	DT
cord-276456-oa6hh7ky	133	25	best	well	RBS
cord-276456-oa6hh7ky	133	26	studied	study	VBN
cord-276456-oa6hh7ky	133	27	fusion	fusion	NN
cord-276456-oa6hh7ky	133	28	protein	protein	NN
cord-276456-oa6hh7ky	133	29	that	that	WDT
cord-276456-oa6hh7ky	133	30	is	be	VBZ
cord-276456-oa6hh7ky	133	31	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	133	32	for	for	IN
cord-276456-oa6hh7ky	133	33	fusion	fusion	NN
cord-276456-oa6hh7ky	133	34	.	.	.
cord-276456-oa6hh7ky	134	1	We	-PRON-	PRP
cord-276456-oa6hh7ky	134	2	learn	learn	VBP
cord-276456-oa6hh7ky	134	3	the	the	DT
cord-276456-oa6hh7ky	134	4	importance	importance	NN
cord-276456-oa6hh7ky	134	5	of	of	IN
cord-276456-oa6hh7ky	134	6	guided	guide	VBN
cord-276456-oa6hh7ky	134	7	conformational	conformational	JJ
cord-276456-oa6hh7ky	134	8	transitions	transition	NNS
cord-276456-oa6hh7ky	134	9	together	together	RB
cord-276456-oa6hh7ky	134	10	with	with	IN
cord-276456-oa6hh7ky	134	11	protein	protein	NN
cord-276456-oa6hh7ky	134	12	-	-	HYPH
cord-276456-oa6hh7ky	134	13	protein	protein	NN
cord-276456-oa6hh7ky	134	14	interactions	interaction	NNS
cord-276456-oa6hh7ky	134	15	in	in	IN
cord-276456-oa6hh7ky	134	16	conjunction	conjunction	NN
cord-276456-oa6hh7ky	134	17	with	with	IN
cord-276456-oa6hh7ky	134	18	clear	clear	JJ
cord-276456-oa6hh7ky	134	19	phenotypic	phenotypic	JJ
cord-276456-oa6hh7ky	134	20	discrimination	discrimination	NN
cord-276456-oa6hh7ky	134	21	between	between	IN
cord-276456-oa6hh7ky	134	22	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	134	23	of	of	IN
cord-276456-oa6hh7ky	134	24	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	134	25	and	and	CC
cord-276456-oa6hh7ky	134	26	the	the	DT
cord-276456-oa6hh7ky	134	27	fusion	fusion	NN
cord-276456-oa6hh7ky	134	28	pore	pore	NN
cord-276456-oa6hh7ky	134	29	opening	opening	NN
cord-276456-oa6hh7ky	134	30	and	and	CC
cord-276456-oa6hh7ky	134	31	subsequent	subsequent	JJ
cord-276456-oa6hh7ky	134	32	widening	widening	NN
cord-276456-oa6hh7ky	134	33	.	.	.
cord-276456-oa6hh7ky	135	1	Clearly	clearly	RB
cord-276456-oa6hh7ky	135	2	there	there	EX
cord-276456-oa6hh7ky	135	3	is	be	VBZ
cord-276456-oa6hh7ky	135	4	much	much	RB
cord-276456-oa6hh7ky	135	5	more	more	JJR
cord-276456-oa6hh7ky	135	6	work	work	NN
cord-276456-oa6hh7ky	135	7	to	to	TO
cord-276456-oa6hh7ky	135	8	be	be	VB
cord-276456-oa6hh7ky	135	9	done	do	VBN
cord-276456-oa6hh7ky	135	10	,	,	,
cord-276456-oa6hh7ky	135	11	because	because	IN
cord-276456-oa6hh7ky	135	12	we	-PRON-	PRP
cord-276456-oa6hh7ky	135	13	do	do	VBP
cord-276456-oa6hh7ky	135	14	not	not	RB
cord-276456-oa6hh7ky	135	15	know	know	VB
cord-276456-oa6hh7ky	135	16	why	why	WRB
cord-276456-oa6hh7ky	135	17	changing	change	VBG
cord-276456-oa6hh7ky	135	18	a	a	DT
cord-276456-oa6hh7ky	135	19	single	single	JJ
cord-276456-oa6hh7ky	135	20	amino	amino	NN
cord-276456-oa6hh7ky	135	21	acid	acid	NN
cord-276456-oa6hh7ky	135	22	residue	residue	NN
cord-276456-oa6hh7ky	135	23	at	at	IN
cord-276456-oa6hh7ky	135	24	the	the	DT
cord-276456-oa6hh7ky	135	25	tip	tip	NN
cord-276456-oa6hh7ky	135	26	of	of	IN
cord-276456-oa6hh7ky	135	27	the	the	DT
cord-276456-oa6hh7ky	135	28	fusion	fusion	NN
cord-276456-oa6hh7ky	135	29	peptide	peptide	NN
cord-276456-oa6hh7ky	135	30	gives	give	VBZ
cord-276456-oa6hh7ky	135	31	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	135	32	instead	instead	RB
cord-276456-oa6hh7ky	135	33	of	of	IN
cord-276456-oa6hh7ky	135	34	fusion	fusion	NN
cord-276456-oa6hh7ky	135	35	.	.	.
cord-276456-oa6hh7ky	136	1	38	38	CD
cord-276456-oa6hh7ky	136	2	HA	HA	NNP
cord-276456-oa6hh7ky	136	3	is	be	VBZ
cord-276456-oa6hh7ky	136	4	the	the	DT
cord-276456-oa6hh7ky	136	5	first	first	JJ
cord-276456-oa6hh7ky	136	6	viral	viral	JJ
cord-276456-oa6hh7ky	136	7	glycoprotein	glycoprotein	NN
cord-276456-oa6hh7ky	136	8	for	for	IN
cord-276456-oa6hh7ky	136	9	which	which	WDT
cord-276456-oa6hh7ky	136	10	the	the	DT
cord-276456-oa6hh7ky	136	11	structures	structure	NNS
cord-276456-oa6hh7ky	136	12	of	of	IN
cord-276456-oa6hh7ky	136	13	both	both	DT
cord-276456-oa6hh7ky	136	14	pre	pre	VB
cord-276456-oa6hh7ky	136	15	-	-	JJ
cord-276456-oa6hh7ky	136	16	and	and	CC
cord-276456-oa6hh7ky	136	17	post	post	JJ
cord-276456-oa6hh7ky	136	18	-	-	JJ
cord-276456-oa6hh7ky	136	19	fusion	fusion	JJ
cord-276456-oa6hh7ky	136	20	forms	form	NNS
cord-276456-oa6hh7ky	136	21	were	be	VBD
cord-276456-oa6hh7ky	136	22	solved	solve	VBN
cord-276456-oa6hh7ky	136	23	at	at	IN
cord-276456-oa6hh7ky	136	24	atomic	atomic	JJ
cord-276456-oa6hh7ky	136	25	resolution	resolution	NN
cord-276456-oa6hh7ky	136	26	.	.	.
cord-276456-oa6hh7ky	137	1	39	39	CD
cord-276456-oa6hh7ky	137	2	,	,	,
cord-276456-oa6hh7ky	137	3	40	40	CD
cord-276456-oa6hh7ky	137	4	HA	HA	NNP
cord-276456-oa6hh7ky	137	5	is	be	VBZ
cord-276456-oa6hh7ky	137	6	synthesized	synthesize	VBN
cord-276456-oa6hh7ky	137	7	as	as	IN
cord-276456-oa6hh7ky	137	8	a	a	DT
cord-276456-oa6hh7ky	137	9	single	single	JJ
cord-276456-oa6hh7ky	137	10	-	-	HYPH
cord-276456-oa6hh7ky	137	11	chain	chain	NN
cord-276456-oa6hh7ky	137	12	precursor	precursor	NN
cord-276456-oa6hh7ky	137	13	protein	protein	NN
cord-276456-oa6hh7ky	137	14	HA0	HA0	NNP
cord-276456-oa6hh7ky	137	15	,	,	,
cord-276456-oa6hh7ky	137	16	which	which	WDT
cord-276456-oa6hh7ky	137	17	then	then	RB
cord-276456-oa6hh7ky	137	18	oligomerizes	oligomerize	VBZ
cord-276456-oa6hh7ky	137	19	into	into	IN
cord-276456-oa6hh7ky	137	20	a	a	DT
cord-276456-oa6hh7ky	137	21	trimer	trimer	NN
cord-276456-oa6hh7ky	137	22	during	during	IN
cord-276456-oa6hh7ky	137	23	protein	protein	NN
cord-276456-oa6hh7ky	137	24	transport	transport	NN
cord-276456-oa6hh7ky	137	25	through	through	IN
cord-276456-oa6hh7ky	137	26	the	the	DT
cord-276456-oa6hh7ky	137	27	secretory	secretory	JJ
cord-276456-oa6hh7ky	137	28	pathway	pathway	NN
cord-276456-oa6hh7ky	137	29	41	41	CD
cord-276456-oa6hh7ky	137	30	.	.	.
cord-276456-oa6hh7ky	138	1	The	the	DT
cord-276456-oa6hh7ky	138	2	precursor	precursor	NN
cord-276456-oa6hh7ky	138	3	HA0	ha0	NN
cord-276456-oa6hh7ky	138	4	(	(	-LRB-
cord-276456-oa6hh7ky	138	5	549	549	CD
cord-276456-oa6hh7ky	138	6	amino	amino	JJ
cord-276456-oa6hh7ky	138	7	acids	acid	NNS
cord-276456-oa6hh7ky	138	8	in	in	IN
cord-276456-oa6hh7ky	138	9	A	A	NNP
cord-276456-oa6hh7ky	138	10	/	/	SYM
cord-276456-oa6hh7ky	138	11	Hong	Hong	NNP
cord-276456-oa6hh7ky	138	12	Kong/68	Kong/68	NNP
cord-276456-oa6hh7ky	138	13	/	/	SYM
cord-276456-oa6hh7ky	138	14	H3N2	H3N2	NNP
cord-276456-oa6hh7ky	138	15	)	)	-RRB-
cord-276456-oa6hh7ky	138	16	then	then	RB
cord-276456-oa6hh7ky	138	17	needs	need	VBZ
cord-276456-oa6hh7ky	138	18	to	to	TO
cord-276456-oa6hh7ky	138	19	be	be	VB
cord-276456-oa6hh7ky	138	20	cleaved	cleave	VBN
cord-276456-oa6hh7ky	138	21	into	into	IN
cord-276456-oa6hh7ky	138	22	the	the	DT
cord-276456-oa6hh7ky	138	23	HA1	HA1	NNP
cord-276456-oa6hh7ky	138	24	and	and	CC
cord-276456-oa6hh7ky	138	25	the	the	DT
cord-276456-oa6hh7ky	138	26	HA2	HA2	NNP
cord-276456-oa6hh7ky	138	27	polypeptides	polypeptide	NNS
cord-276456-oa6hh7ky	138	28	after	after	IN
cord-276456-oa6hh7ky	138	29	the	the	DT
cord-276456-oa6hh7ky	138	30	conserved	conserve	VBN
cord-276456-oa6hh7ky	138	31	arginine	arginine	NN
cord-276456-oa6hh7ky	138	32	at	at	IN
cord-276456-oa6hh7ky	138	33	residue	residue	NN
cord-276456-oa6hh7ky	138	34	329	329	CD
cord-276456-oa6hh7ky	138	35	to	to	TO
cord-276456-oa6hh7ky	138	36	be	be	VB
cord-276456-oa6hh7ky	138	37	primed	prime	VBN
cord-276456-oa6hh7ky	138	38	for	for	IN
cord-276456-oa6hh7ky	138	39	the	the	DT
cord-276456-oa6hh7ky	138	40	subsequent	subsequent	JJ
cord-276456-oa6hh7ky	138	41	low	low	JJ
cord-276456-oa6hh7ky	138	42	pH	ph	NN
cord-276456-oa6hh7ky	138	43	-	-	HYPH
cord-276456-oa6hh7ky	138	44	triggered	trigger	VBN
cord-276456-oa6hh7ky	138	45	conformational	conformational	JJ
cord-276456-oa6hh7ky	138	46	changes	change	NNS
cord-276456-oa6hh7ky	138	47	(	(	-LRB-
cord-276456-oa6hh7ky	138	48	Figure	figure	NN
cord-276456-oa6hh7ky	138	49	3	3	CD
cord-276456-oa6hh7ky	138	50	)	)	-RRB-
cord-276456-oa6hh7ky	138	51	.	.	.
cord-276456-oa6hh7ky	139	1	42	42	CD
cord-276456-oa6hh7ky	140	1	Although	although	IN
cord-276456-oa6hh7ky	140	2	the	the	DT
cord-276456-oa6hh7ky	140	3	crystal	crystal	NN
cord-276456-oa6hh7ky	140	4	structures	structure	NNS
cord-276456-oa6hh7ky	140	5	of	of	IN
cord-276456-oa6hh7ky	140	6	both	both	DT
cord-276456-oa6hh7ky	140	7	pre	pre	VB
cord-276456-oa6hh7ky	140	8	-	-	JJ
cord-276456-oa6hh7ky	140	9	and	and	CC
cord-276456-oa6hh7ky	140	10	post	post	JJ
cord-276456-oa6hh7ky	140	11	-	-	JJ
cord-276456-oa6hh7ky	140	12	fusion	fusion	JJ
cord-276456-oa6hh7ky	140	13	forms	form	NNS
cord-276456-oa6hh7ky	140	14	of	of	IN
cord-276456-oa6hh7ky	140	15	HA	HA	NNP
cord-276456-oa6hh7ky	140	16	have	have	VBP
cord-276456-oa6hh7ky	140	17	been	be	VBN
cord-276456-oa6hh7ky	140	18	available	available	JJ
cord-276456-oa6hh7ky	140	19	for	for	IN
cord-276456-oa6hh7ky	140	20	more	more	JJR
cord-276456-oa6hh7ky	140	21	than	than	IN
cord-276456-oa6hh7ky	140	22	a	a	DT
cord-276456-oa6hh7ky	140	23	decade	decade	NN
cord-276456-oa6hh7ky	141	1	(	(	-LRB-
cord-276456-oa6hh7ky	141	2	Figure	figure	NN
cord-276456-oa6hh7ky	141	3	4	4	CD
cord-276456-oa6hh7ky	141	4	)	)	-RRB-
cord-276456-oa6hh7ky	141	5	,	,	,
cord-276456-oa6hh7ky	141	6	we	-PRON-	PRP
cord-276456-oa6hh7ky	141	7	still	still	RB
cord-276456-oa6hh7ky	141	8	do	do	VBP
cord-276456-oa6hh7ky	141	9	not	not	RB
cord-276456-oa6hh7ky	141	10	know	know	VB
cord-276456-oa6hh7ky	141	11	exactly	exactly	RB
cord-276456-oa6hh7ky	141	12	how	how	WRB
cord-276456-oa6hh7ky	141	13	conformational	conformational	JJ
cord-276456-oa6hh7ky	141	14	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	141	15	occur	occur	VBP
cord-276456-oa6hh7ky	141	16	step	step	NN
cord-276456-oa6hh7ky	141	17	by	by	IN
cord-276456-oa6hh7ky	141	18	step	step	NN
cord-276456-oa6hh7ky	141	19	,	,	,
cord-276456-oa6hh7ky	141	20	how	how	WRB
cord-276456-oa6hh7ky	141	21	low	low	JJ
cord-276456-oa6hh7ky	141	22	pH	pH	NNP
cord-276456-oa6hh7ky	141	23	environment	environment	NN
cord-276456-oa6hh7ky	141	24	triggers	trigger	VBZ
cord-276456-oa6hh7ky	141	25	the	the	DT
cord-276456-oa6hh7ky	141	26	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	141	27	of	of	IN
cord-276456-oa6hh7ky	141	28	the	the	DT
cord-276456-oa6hh7ky	141	29	HA	HA	NNP
cord-276456-oa6hh7ky	141	30	ectodomain	ectodomain	NN
cord-276456-oa6hh7ky	141	31	,	,	,
cord-276456-oa6hh7ky	141	32	and	and	CC
cord-276456-oa6hh7ky	141	33	which	which	WDT
cord-276456-oa6hh7ky	141	34	structural	structural	JJ
cord-276456-oa6hh7ky	141	35	elements	element	NNS
cord-276456-oa6hh7ky	141	36	are	be	VBP
cord-276456-oa6hh7ky	141	37	crucial	crucial	JJ
cord-276456-oa6hh7ky	141	38	for	for	IN
cord-276456-oa6hh7ky	141	39	HA	HA	NNP
cord-276456-oa6hh7ky	141	40	fusion	fusion	NN
cord-276456-oa6hh7ky	141	41	activity	activity	NN
cord-276456-oa6hh7ky	141	42	.	.	.
cord-276456-oa6hh7ky	142	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	142	2	has	have	VBZ
cord-276456-oa6hh7ky	142	3	been	be	VBN
cord-276456-oa6hh7ky	142	4	suggested	suggest	VBN
cord-276456-oa6hh7ky	142	5	that	that	IN
cord-276456-oa6hh7ky	142	6	the	the	DT
cord-276456-oa6hh7ky	142	7	low	low	JJ
cord-276456-oa6hh7ky	142	8	pH	ph	NN
cord-276456-oa6hh7ky	142	9	might	may	MD
cord-276456-oa6hh7ky	142	10	lead	lead	VB
cord-276456-oa6hh7ky	142	11	to	to	IN
cord-276456-oa6hh7ky	142	12	an	an	DT
cord-276456-oa6hh7ky	142	13	enhanced	enhance	VBN
cord-276456-oa6hh7ky	142	14	protonation	protonation	NN
cord-276456-oa6hh7ky	142	15	of	of	IN
cord-276456-oa6hh7ky	142	16	the	the	DT
cord-276456-oa6hh7ky	142	17	HA1	HA1	NNP
cord-276456-oa6hh7ky	142	18	domain	domain	NN
cord-276456-oa6hh7ky	142	19	,	,	,
cord-276456-oa6hh7ky	142	20	and	and	CC
cord-276456-oa6hh7ky	142	21	generate	generate	VB
cord-276456-oa6hh7ky	142	22	enough	enough	JJ
cord-276456-oa6hh7ky	142	23	electrostatic	electrostatic	JJ
cord-276456-oa6hh7ky	142	24	repulsion	repulsion	NN
cord-276456-oa6hh7ky	142	25	force	force	NN
cord-276456-oa6hh7ky	142	26	to	to	TO
cord-276456-oa6hh7ky	142	27	partially	partially	RB
cord-276456-oa6hh7ky	142	28	dissociate	dissociate	VB
cord-276456-oa6hh7ky	142	29	the	the	DT
cord-276456-oa6hh7ky	142	30	HA1	HA1	NNP
cord-276456-oa6hh7ky	142	31	domain	domain	NN
cord-276456-oa6hh7ky	142	32	from	from	IN
cord-276456-oa6hh7ky	142	33	the	the	DT
cord-276456-oa6hh7ky	142	34	HA2	HA2	NNP
cord-276456-oa6hh7ky	142	35	to	to	TO
cord-276456-oa6hh7ky	142	36	allow	allow	VB
cord-276456-oa6hh7ky	142	37	the	the	DT
cord-276456-oa6hh7ky	142	38	loop	loop	NN
cord-276456-oa6hh7ky	142	39	region	region	NN
cord-276456-oa6hh7ky	142	40	in	in	IN
cord-276456-oa6hh7ky	142	41	the	the	DT
cord-276456-oa6hh7ky	142	42	HA2	HA2	NNP
cord-276456-oa6hh7ky	142	43	to	to	TO
cord-276456-oa6hh7ky	142	44	contact	contact	VB
cord-276456-oa6hh7ky	142	45	with	with	IN
cord-276456-oa6hh7ky	142	46	water	water	NN
cord-276456-oa6hh7ky	142	47	;	;	:
cord-276456-oa6hh7ky	142	48	this	this	DT
cord-276456-oa6hh7ky	142	49	would	would	MD
cord-276456-oa6hh7ky	142	50	cause	cause	VB
cord-276456-oa6hh7ky	142	51	the	the	DT
cord-276456-oa6hh7ky	142	52	loop	loop	NN
cord-276456-oa6hh7ky	142	53	to	to	IN
cord-276456-oa6hh7ky	142	54	transition	transition	NN
cord-276456-oa6hh7ky	142	55	into	into	IN
cord-276456-oa6hh7ky	142	56	a	a	DT
cord-276456-oa6hh7ky	142	57	helix	helix	NN
cord-276456-oa6hh7ky	142	58	and	and	CC
cord-276456-oa6hh7ky	142	59	extend	extend	VB
cord-276456-oa6hh7ky	142	60	the	the	DT
cord-276456-oa6hh7ky	142	61	pre	pre	JJ
cord-276456-oa6hh7ky	142	62	-	-	JJ
cord-276456-oa6hh7ky	142	63	existing	existing	JJ
cord-276456-oa6hh7ky	142	64	central	central	JJ
cord-276456-oa6hh7ky	142	65	coiled	coiled	JJ
cord-276456-oa6hh7ky	142	66	coil	coil	NN
cord-276456-oa6hh7ky	142	67	(	(	-LRB-
cord-276456-oa6hh7ky	142	68	Figure	figure	NN
cord-276456-oa6hh7ky	142	69	5	5	CD
cord-276456-oa6hh7ky	142	70	)	)	-RRB-
cord-276456-oa6hh7ky	142	71	.	.	.
cord-276456-oa6hh7ky	143	1	[	[	-LRB-
cord-276456-oa6hh7ky	143	2	44	44	CD
cord-276456-oa6hh7ky	143	3	]	]	-RRB-
cord-276456-oa6hh7ky	143	4	[	[	-LRB-
cord-276456-oa6hh7ky	143	5	45	45	CD
cord-276456-oa6hh7ky	143	6	]	]	-RRB-
cord-276456-oa6hh7ky	144	1	[	[	-LRB-
cord-276456-oa6hh7ky	144	2	46	46	CD
cord-276456-oa6hh7ky	144	3	]	]	-RRB-
cord-276456-oa6hh7ky	145	1	In	in	IN
cord-276456-oa6hh7ky	145	2	this	this	DT
cord-276456-oa6hh7ky	145	3	model	model	NN
cord-276456-oa6hh7ky	145	4	,	,	,
cord-276456-oa6hh7ky	145	5	it	-PRON-	PRP
cord-276456-oa6hh7ky	145	6	seems	seem	VBZ
cord-276456-oa6hh7ky	145	7	that	that	IN
cord-276456-oa6hh7ky	145	8	the	the	DT
cord-276456-oa6hh7ky	145	9	only	only	JJ
cord-276456-oa6hh7ky	145	10	step	step	NN
cord-276456-oa6hh7ky	145	11	requiring	require	VBG
cord-276456-oa6hh7ky	145	12	a	a	DT
cord-276456-oa6hh7ky	145	13	low	low	JJ
cord-276456-oa6hh7ky	145	14	pH	ph	NN
cord-276456-oa6hh7ky	145	15	trigger	trigger	NN
cord-276456-oa6hh7ky	145	16	is	be	VBZ
cord-276456-oa6hh7ky	145	17	the	the	DT
cord-276456-oa6hh7ky	145	18	exposure	exposure	NN
cord-276456-oa6hh7ky	145	19	of	of	IN
cord-276456-oa6hh7ky	145	20	the	the	DT
cord-276456-oa6hh7ky	145	21	loop	loop	NN
cord-276456-oa6hh7ky	145	22	region	region	NN
cord-276456-oa6hh7ky	145	23	connecting	connect	VBG
cord-276456-oa6hh7ky	145	24	the	the	DT
cord-276456-oa6hh7ky	145	25	two	two	CD
cord-276456-oa6hh7ky	145	26	alpha	alpha	NN
cord-276456-oa6hh7ky	145	27	helices	helix	NNS
cord-276456-oa6hh7ky	145	28	in	in	IN
cord-276456-oa6hh7ky	145	29	HA2	HA2	NNP
cord-276456-oa6hh7ky	145	30	to	to	IN
cord-276456-oa6hh7ky	145	31	water	water	NN
cord-276456-oa6hh7ky	145	32	by	by	IN
cord-276456-oa6hh7ky	145	33	partial	partial	JJ
cord-276456-oa6hh7ky	145	34	disorientation	disorientation	NN
cord-276456-oa6hh7ky	145	35	of	of	IN
cord-276456-oa6hh7ky	145	36	HA1	HA1	NNP
cord-276456-oa6hh7ky	145	37	from	from	IN
cord-276456-oa6hh7ky	145	38	HA2	HA2	NNP
cord-276456-oa6hh7ky	145	39	.	.	.
cord-276456-oa6hh7ky	146	1	Consistent	consistent	JJ
cord-276456-oa6hh7ky	146	2	with	with	IN
cord-276456-oa6hh7ky	146	3	this	this	DT
cord-276456-oa6hh7ky	146	4	idea	idea	NN
cord-276456-oa6hh7ky	146	5	,	,	,
cord-276456-oa6hh7ky	146	6	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	146	7	formation	formation	NN
cord-276456-oa6hh7ky	146	8	of	of	IN
cord-276456-oa6hh7ky	146	9	extended	extended	JJ
cord-276456-oa6hh7ky	146	10	coiled	coiled	JJ
cord-276456-oa6hh7ky	146	11	coils	coil	NNS
cord-276456-oa6hh7ky	146	12	are	be	VBP
cord-276456-oa6hh7ky	146	13	observed	observe	VBN
cord-276456-oa6hh7ky	146	14	in	in	IN
cord-276456-oa6hh7ky	146	15	bacterially	bacterially	RB
cord-276456-oa6hh7ky	146	16	expressed	express	VBN
cord-276456-oa6hh7ky	146	17	HA2	HA2	NNP
cord-276456-oa6hh7ky	146	18	polypeptide	polypeptide	NN
cord-276456-oa6hh7ky	146	19	at	at	IN
cord-276456-oa6hh7ky	146	20	neutral	neutral	JJ
cord-276456-oa6hh7ky	146	21	pH	pH	NNP
cord-276456-oa6hh7ky	146	22	,	,	,
cord-276456-oa6hh7ky	146	23	indicating	indicate	VBG
cord-276456-oa6hh7ky	146	24	that	that	IN
cord-276456-oa6hh7ky	146	25	the	the	DT
cord-276456-oa6hh7ky	146	26	low	low	JJ
cord-276456-oa6hh7ky	146	27	pH	pH	NNP
cord-276456-oa6hh7ky	146	28	trigger	trigger	NN
cord-276456-oa6hh7ky	146	29	is	be	VBZ
cord-276456-oa6hh7ky	146	30	not	not	RB
cord-276456-oa6hh7ky	146	31	necessary	necessary	JJ
cord-276456-oa6hh7ky	146	32	for	for	IN
cord-276456-oa6hh7ky	146	33	the	the	DT
cord-276456-oa6hh7ky	146	34	extension	extension	NN
cord-276456-oa6hh7ky	146	35	of	of	IN
cord-276456-oa6hh7ky	146	36	coiled	coiled	JJ
cord-276456-oa6hh7ky	146	37	coils	coil	NNS
cord-276456-oa6hh7ky	146	38	.	.	.
cord-276456-oa6hh7ky	147	1	47	47	CD
cord-276456-oa6hh7ky	148	1	The	the	DT
cord-276456-oa6hh7ky	148	2	prevailing	prevail	VBG
cord-276456-oa6hh7ky	148	3	hypothesis	hypothesis	NN
cord-276456-oa6hh7ky	148	4	for	for	IN
cord-276456-oa6hh7ky	148	5	the	the	DT
cord-276456-oa6hh7ky	148	6	mechanism	mechanism	NN
cord-276456-oa6hh7ky	148	7	of	of	IN
cord-276456-oa6hh7ky	148	8	how	how	WRB
cord-276456-oa6hh7ky	148	9	conformational	conformational	JJ
cord-276456-oa6hh7ky	148	10	changes	change	NNS
cord-276456-oa6hh7ky	148	11	lead	lead	VBP
cord-276456-oa6hh7ky	148	12	to	to	IN
cord-276456-oa6hh7ky	148	13	the	the	DT
cord-276456-oa6hh7ky	148	14	fusion	fusion	NN
cord-276456-oa6hh7ky	148	15	of	of	IN
cord-276456-oa6hh7ky	148	16	two	two	CD
cord-276456-oa6hh7ky	148	17	membranes	membrane	NNS
cord-276456-oa6hh7ky	148	18	is	be	VBZ
cord-276456-oa6hh7ky	148	19	that	that	DT
cord-276456-oa6hh7ky	148	20	extension	extension	NN
cord-276456-oa6hh7ky	148	21	of	of	IN
cord-276456-oa6hh7ky	148	22	coiled	coiled	JJ
cord-276456-oa6hh7ky	148	23	coils	coil	NNS
cord-276456-oa6hh7ky	148	24	triggered	trigger	VBN
cord-276456-oa6hh7ky	148	25	by	by	IN
cord-276456-oa6hh7ky	148	26	the	the	DT
cord-276456-oa6hh7ky	148	27	low	low	JJ
cord-276456-oa6hh7ky	148	28	pH	pH	NNP
cord-276456-oa6hh7ky	148	29	directs	direct	VBZ
cord-276456-oa6hh7ky	148	30	the	the	DT
cord-276456-oa6hh7ky	148	31	fusion	fusion	NN
cord-276456-oa6hh7ky	148	32	peptide	peptide	NN
cord-276456-oa6hh7ky	148	33	to	to	TO
cord-276456-oa6hh7ky	148	34	insert	insert	VB
cord-276456-oa6hh7ky	148	35	into	into	IN
cord-276456-oa6hh7ky	148	36	the	the	DT
cord-276456-oa6hh7ky	148	37	target	target	NN
cord-276456-oa6hh7ky	148	38	membrane	membrane	NN
cord-276456-oa6hh7ky	148	39	,	,	,
cord-276456-oa6hh7ky	148	40	and	and	CC
cord-276456-oa6hh7ky	148	41	then	then	RB
cord-276456-oa6hh7ky	148	42	a	a	DT
cord-276456-oa6hh7ky	148	43	helix	helix	NN
cord-276456-oa6hh7ky	148	44	-	-	HYPH
cord-276456-oa6hh7ky	148	45	to	to	IN
cord-276456-oa6hh7ky	148	46	-	-	HYPH
cord-276456-oa6hh7ky	148	47	loop	loop	NN
cord-276456-oa6hh7ky	148	48	conformational	conformational	JJ
cord-276456-oa6hh7ky	148	49	change	change	NN
cord-276456-oa6hh7ky	148	50	reorients	reorient	VBZ
cord-276456-oa6hh7ky	148	51	the	the	DT
cord-276456-oa6hh7ky	148	52	protein	protein	NN
cord-276456-oa6hh7ky	148	53	to	to	TO
cord-276456-oa6hh7ky	148	54	pull	pull	VB
cord-276456-oa6hh7ky	148	55	the	the	DT
cord-276456-oa6hh7ky	148	56	fusion	fusion	NN
cord-276456-oa6hh7ky	148	57	peptide	peptide	NN
cord-276456-oa6hh7ky	148	58	toward	toward	IN
cord-276456-oa6hh7ky	148	59	the	the	DT
cord-276456-oa6hh7ky	148	60	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	148	61	domain	domain	NN
cord-276456-oa6hh7ky	148	62	.	.	.
cord-276456-oa6hh7ky	149	1	These	these	DT
cord-276456-oa6hh7ky	149	2	molecular	molecular	JJ
cord-276456-oa6hh7ky	149	3	transitions	transition	NNS
cord-276456-oa6hh7ky	149	4	result	result	VBP
cord-276456-oa6hh7ky	149	5	in	in	IN
cord-276456-oa6hh7ky	149	6	a	a	DT
cord-276456-oa6hh7ky	149	7	tight	tight	JJ
cord-276456-oa6hh7ky	149	8	packing	packing	NN
cord-276456-oa6hh7ky	149	9	of	of	IN
cord-276456-oa6hh7ky	149	10	the	the	DT
cord-276456-oa6hh7ky	149	11	COOH	COOH	NNP
cord-276456-oa6hh7ky	149	12	-	-	HYPH
cord-276456-oa6hh7ky	149	13	terminus	terminus	NN
cord-276456-oa6hh7ky	149	14	of	of	IN
cord-276456-oa6hh7ky	149	15	HA2	HA2	NNP
cord-276456-oa6hh7ky	149	16	against	against	IN
cord-276456-oa6hh7ky	149	17	grooves	groove	NNS
cord-276456-oa6hh7ky	149	18	of	of	IN
cord-276456-oa6hh7ky	149	19	the	the	DT
cord-276456-oa6hh7ky	149	20	NH	NH	NNP
cord-276456-oa6hh7ky	149	21	2	2	CD
cord-276456-oa6hh7ky	149	22	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	149	23	coiled	coiled	JJ
cord-276456-oa6hh7ky	149	24	coil	coil	NN
cord-276456-oa6hh7ky	149	25	,	,	,
cord-276456-oa6hh7ky	149	26	proceeding	proceed	VBG
cord-276456-oa6hh7ky	149	27	to	to	IN
cord-276456-oa6hh7ky	149	28	the	the	DT
cord-276456-oa6hh7ky	149	29	fusion	fusion	NN
cord-276456-oa6hh7ky	149	30	of	of	IN
cord-276456-oa6hh7ky	149	31	the	the	DT
cord-276456-oa6hh7ky	149	32	two	two	CD
cord-276456-oa6hh7ky	149	33	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	149	34	.	.	.
cord-276456-oa6hh7ky	150	1	[	[	-LRB-
cord-276456-oa6hh7ky	150	2	48	48	CD
cord-276456-oa6hh7ky	150	3	]	]	-RRB-
cord-276456-oa6hh7ky	150	4	[	[	-LRB-
cord-276456-oa6hh7ky	150	5	49	49	CD
cord-276456-oa6hh7ky	150	6	]	]	-RRB-
cord-276456-oa6hh7ky	151	1	[	[	-LRB-
cord-276456-oa6hh7ky	151	2	50	50	CD
cord-276456-oa6hh7ky	151	3	]	]	-RRB-
cord-276456-oa6hh7ky	152	1	This	this	DT
cord-276456-oa6hh7ky	152	2	hypothesis	hypothesis	NN
cord-276456-oa6hh7ky	152	3	emphasizes	emphasize	VBZ
cord-276456-oa6hh7ky	152	4	that	that	IN
cord-276456-oa6hh7ky	152	5	both	both	CC
cord-276456-oa6hh7ky	152	6	the	the	DT
cord-276456-oa6hh7ky	152	7	extension	extension	NN
cord-276456-oa6hh7ky	152	8	of	of	IN
cord-276456-oa6hh7ky	152	9	the	the	DT
cord-276456-oa6hh7ky	152	10	coiled	coiled	JJ
cord-276456-oa6hh7ky	152	11	coil	coil	NN
cord-276456-oa6hh7ky	152	12	and	and	CC
cord-276456-oa6hh7ky	152	13	the	the	DT
cord-276456-oa6hh7ky	152	14	bending	bending	NN
cord-276456-oa6hh7ky	152	15	of	of	IN
cord-276456-oa6hh7ky	152	16	the	the	DT
cord-276456-oa6hh7ky	152	17	protein	protein	NN
cord-276456-oa6hh7ky	152	18	resulting	result	VBG
cord-276456-oa6hh7ky	152	19	from	from	IN
cord-276456-oa6hh7ky	152	20	the	the	DT
cord-276456-oa6hh7ky	152	21	helix	helix	NN
cord-276456-oa6hh7ky	152	22	-	-	HYPH
cord-276456-oa6hh7ky	152	23	to	to	IN
cord-276456-oa6hh7ky	152	24	-	-	HYPH
cord-276456-oa6hh7ky	152	25	loop	loop	NN
cord-276456-oa6hh7ky	152	26	conformational	conformational	JJ
cord-276456-oa6hh7ky	152	27	change	change	NN
cord-276456-oa6hh7ky	152	28	are	be	VBP
cord-276456-oa6hh7ky	152	29	important	important	JJ
cord-276456-oa6hh7ky	152	30	for	for	IN
cord-276456-oa6hh7ky	152	31	fusion	fusion	NN
cord-276456-oa6hh7ky	152	32	.	.	.
cord-276456-oa6hh7ky	153	1	The	the	DT
cord-276456-oa6hh7ky	153	2	experimental	experimental	JJ
cord-276456-oa6hh7ky	153	3	results	result	NNS
cord-276456-oa6hh7ky	153	4	favoring	favor	VBG
cord-276456-oa6hh7ky	153	5	this	this	DT
cord-276456-oa6hh7ky	153	6	hypothesis	hypothesis	NN
cord-276456-oa6hh7ky	153	7	demonstrate	demonstrate	VBP
cord-276456-oa6hh7ky	153	8	that	that	IN
cord-276456-oa6hh7ky	153	9	a	a	DT
cord-276456-oa6hh7ky	153	10	double	double	JJ
cord-276456-oa6hh7ky	153	11	proline	proline	NN
cord-276456-oa6hh7ky	153	12	substitution	substitution	NN
cord-276456-oa6hh7ky	153	13	mutant	mutant	NN
cord-276456-oa6hh7ky	153	14	(	(	-LRB-
cord-276456-oa6hh7ky	153	15	F63P	F63P	NNP
cord-276456-oa6hh7ky	153	16	/	/	SYM
cord-276456-oa6hh7ky	153	17	F70P	F70P	NNP
cord-276456-oa6hh7ky	153	18	)	)	-RRB-
cord-276456-oa6hh7ky	153	19	at	at	IN
cord-276456-oa6hh7ky	153	20	the	the	DT
cord-276456-oa6hh7ky	153	21	region	region	NN
cord-276456-oa6hh7ky	153	22	supposedly	supposedly	RB
cord-276456-oa6hh7ky	153	23	undergoing	undergo	VBG
cord-276456-oa6hh7ky	153	24	loop	loop	NN
cord-276456-oa6hh7ky	153	25	-	-	HYPH
cord-276456-oa6hh7ky	153	26	to	to	IN
cord-276456-oa6hh7ky	153	27	-	-	HYPH
cord-276456-oa6hh7ky	153	28	helix	helix	NN
cord-276456-oa6hh7ky	153	29	conformational	conformational	JJ
cord-276456-oa6hh7ky	153	30	change	change	NN
cord-276456-oa6hh7ky	153	31	upon	upon	IN
cord-276456-oa6hh7ky	153	32	low	low	JJ
cord-276456-oa6hh7ky	153	33	pH	pH	NNP
cord-276456-oa6hh7ky	153	34	failed	fail	VBD
cord-276456-oa6hh7ky	153	35	to	to	TO
cord-276456-oa6hh7ky	153	36	induce	induce	VB
cord-276456-oa6hh7ky	153	37	fusion	fusion	NN
cord-276456-oa6hh7ky	153	38	,	,	,
cord-276456-oa6hh7ky	153	39	although	although	IN
cord-276456-oa6hh7ky	153	40	the	the	DT
cord-276456-oa6hh7ky	153	41	mutant	mutant	NN
cord-276456-oa6hh7ky	153	42	still	still	RB
cord-276456-oa6hh7ky	153	43	presented	present	VBN
cord-276456-oa6hh7ky	153	44	and	and	CC
cord-276456-oa6hh7ky	153	45	inserted	insert	VBD
cord-276456-oa6hh7ky	153	46	the	the	DT
cord-276456-oa6hh7ky	153	47	fusion	fusion	NN
cord-276456-oa6hh7ky	153	48	peptide	peptide	NN
cord-276456-oa6hh7ky	153	49	to	to	IN
cord-276456-oa6hh7ky	153	50	the	the	DT
cord-276456-oa6hh7ky	153	51	target	target	NN
cord-276456-oa6hh7ky	153	52	membrane	membrane	NN
cord-276456-oa6hh7ky	153	53	.	.	.
cord-276456-oa6hh7ky	154	1	50	50	CD
cord-276456-oa6hh7ky	155	1	The	the	DT
cord-276456-oa6hh7ky	155	2	block	block	NN
cord-276456-oa6hh7ky	155	3	to	to	IN
cord-276456-oa6hh7ky	155	4	fusion	fusion	NN
cord-276456-oa6hh7ky	155	5	was	be	VBD
cord-276456-oa6hh7ky	155	6	demonstrated	demonstrate	VBN
cord-276456-oa6hh7ky	155	7	to	to	TO
cord-276456-oa6hh7ky	155	8	occur	occur	VB
cord-276456-oa6hh7ky	155	9	in	in	IN
cord-276456-oa6hh7ky	155	10	the	the	DT
cord-276456-oa6hh7ky	155	11	tight	tight	JJ
cord-276456-oa6hh7ky	155	12	packing	packing	NN
cord-276456-oa6hh7ky	155	13	of	of	IN
cord-276456-oa6hh7ky	155	14	COOH	COOH	NNP
cord-276456-oa6hh7ky	155	15	-	-	HYPH
cord-276456-oa6hh7ky	155	16	terminal	terminal	NN
cord-276456-oa6hh7ky	155	17	extended	extended	JJ
cord-276456-oa6hh7ky	155	18	regions	region	NNS
cord-276456-oa6hh7ky	155	19	into	into	IN
cord-276456-oa6hh7ky	155	20	the	the	DT
cord-276456-oa6hh7ky	155	21	grooves	groove	NNS
cord-276456-oa6hh7ky	155	22	between	between	IN
cord-276456-oa6hh7ky	155	23	the	the	DT
cord-276456-oa6hh7ky	155	24	helices	helix	NNS
cord-276456-oa6hh7ky	155	25	of	of	IN
cord-276456-oa6hh7ky	155	26	the	the	DT
cord-276456-oa6hh7ky	155	27	NH	NH	NNP
cord-276456-oa6hh7ky	155	28	2	2	CD
cord-276456-oa6hh7ky	155	29	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	155	30	half	half	NN
cord-276456-oa6hh7ky	155	31	of	of	IN
cord-276456-oa6hh7ky	155	32	the	the	DT
cord-276456-oa6hh7ky	155	33	coiled	coiled	JJ
cord-276456-oa6hh7ky	155	34	coil	coil	NN
cord-276456-oa6hh7ky	155	35	due	due	IN
cord-276456-oa6hh7ky	155	36	to	to	IN
cord-276456-oa6hh7ky	155	37	the	the	DT
cord-276456-oa6hh7ky	155	38	splayed	splay	VBN
cord-276456-oa6hh7ky	155	39	NH	NH	NNP
cord-276456-oa6hh7ky	155	40	2	2	CD
cord-276456-oa6hh7ky	156	1	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	156	2	half	half	NN
cord-276456-oa6hh7ky	156	3	of	of	IN
cord-276456-oa6hh7ky	156	4	HA2	HA2	NNP
cord-276456-oa6hh7ky	156	5	,	,	,
cord-276456-oa6hh7ky	156	6	suggesting	suggest	VBG
cord-276456-oa6hh7ky	156	7	that	that	IN
cord-276456-oa6hh7ky	156	8	the	the	DT
cord-276456-oa6hh7ky	156	9	insertion	insertion	NN
cord-276456-oa6hh7ky	156	10	of	of	IN
cord-276456-oa6hh7ky	156	11	fusion	fusion	NN
cord-276456-oa6hh7ky	156	12	peptide	peptide	NN
cord-276456-oa6hh7ky	156	13	into	into	IN
cord-276456-oa6hh7ky	156	14	target	target	NN
cord-276456-oa6hh7ky	156	15	membrane	membrane	NN
cord-276456-oa6hh7ky	156	16	alone	alone	RB
cord-276456-oa6hh7ky	156	17	is	be	VBZ
cord-276456-oa6hh7ky	156	18	not	not	RB
cord-276456-oa6hh7ky	156	19	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	156	20	for	for	IN
cord-276456-oa6hh7ky	156	21	fusion	fusion	NN
cord-276456-oa6hh7ky	156	22	,	,	,
cord-276456-oa6hh7ky	156	23	and	and	CC
cord-276456-oa6hh7ky	156	24	the	the	DT
cord-276456-oa6hh7ky	156	25	tension	tension	NN
cord-276456-oa6hh7ky	156	26	caused	cause	VBN
cord-276456-oa6hh7ky	156	27	by	by	IN
cord-276456-oa6hh7ky	156	28	the	the	DT
cord-276456-oa6hh7ky	156	29	packing	packing	NN
cord-276456-oa6hh7ky	156	30	of	of	IN
cord-276456-oa6hh7ky	156	31	COOH	COOH	NNP
cord-276456-oa6hh7ky	156	32	-	-	HYPH
cord-276456-oa6hh7ky	156	33	terminus	terminus	NN
cord-276456-oa6hh7ky	156	34	against	against	IN
cord-276456-oa6hh7ky	156	35	the	the	DT
cord-276456-oa6hh7ky	156	36	NH	NH	NNP
cord-276456-oa6hh7ky	156	37	2	2	CD
cord-276456-oa6hh7ky	156	38	-terminus	-terminus	:
cord-276456-oa6hh7ky	156	39	of	of	IN
cord-276456-oa6hh7ky	156	40	HA2	HA2	NNP
cord-276456-oa6hh7ky	156	41	may	may	MD
cord-276456-oa6hh7ky	156	42	be	be	VB
cord-276456-oa6hh7ky	156	43	the	the	DT
cord-276456-oa6hh7ky	156	44	driving	drive	VBG
cord-276456-oa6hh7ky	156	45	force	force	NN
cord-276456-oa6hh7ky	156	46	for	for	IN
cord-276456-oa6hh7ky	156	47	membrane	membrane	NN
cord-276456-oa6hh7ky	156	48	merging	merging	NN
cord-276456-oa6hh7ky	156	49	.	.	.
cord-276456-oa6hh7ky	157	1	Another	another	DT
cord-276456-oa6hh7ky	157	2	piece	piece	NN
cord-276456-oa6hh7ky	157	3	of	of	IN
cord-276456-oa6hh7ky	157	4	evidence	evidence	NN
cord-276456-oa6hh7ky	157	5	for	for	IN
cord-276456-oa6hh7ky	157	6	the	the	DT
cord-276456-oa6hh7ky	157	7	role	role	NN
cord-276456-oa6hh7ky	157	8	of	of	IN
cord-276456-oa6hh7ky	157	9	the	the	DT
cord-276456-oa6hh7ky	157	10	packing	packing	NN
cord-276456-oa6hh7ky	157	11	of	of	IN
cord-276456-oa6hh7ky	157	12	the	the	DT
cord-276456-oa6hh7ky	157	13	COOH	COOH	NNP
cord-276456-oa6hh7ky	157	14	-	-	HYPH
cord-276456-oa6hh7ky	157	15	terminus	terminus	NN
cord-276456-oa6hh7ky	157	16	to	to	IN
cord-276456-oa6hh7ky	157	17	the	the	DT
cord-276456-oa6hh7ky	157	18	NH	NH	NNP
cord-276456-oa6hh7ky	157	19	2	2	CD
cord-276456-oa6hh7ky	157	20	-terminus	-terminu	VBN
cord-276456-oa6hh7ky	157	21	in	in	IN
cord-276456-oa6hh7ky	157	22	viral	viral	JJ
cord-276456-oa6hh7ky	157	23	fusion	fusion	NN
cord-276456-oa6hh7ky	157	24	is	be	VBZ
cord-276456-oa6hh7ky	157	25	that	that	IN
cord-276456-oa6hh7ky	157	26	the	the	DT
cord-276456-oa6hh7ky	157	27	alanine	alanine	JJ
cord-276456-oa6hh7ky	157	28	substitution	substitution	NN
cord-276456-oa6hh7ky	157	29	mutants	mutant	NNS
cord-276456-oa6hh7ky	157	30	at	at	IN
cord-276456-oa6hh7ky	157	31	five	five	CD
cord-276456-oa6hh7ky	157	32	apolar	apolar	NNP
cord-276456-oa6hh7ky	157	33	residues	residue	NNS
cord-276456-oa6hh7ky	157	34	after	after	IN
cord-276456-oa6hh7ky	157	35	the	the	DT
cord-276456-oa6hh7ky	157	36	short	short	JJ
cord-276456-oa6hh7ky	157	37	COOH	COOH	NNP
cord-276456-oa6hh7ky	157	38	-	-	HYPH
cord-276456-oa6hh7ky	157	39	terminus	terminus	NN
cord-276456-oa6hh7ky	157	40	of	of	IN
cord-276456-oa6hh7ky	157	41	HA2	HA2	NNP
cord-276456-oa6hh7ky	157	42	fails	fail	VBZ
cord-276456-oa6hh7ky	157	43	to	to	TO
cord-276456-oa6hh7ky	157	44	cause	cause	VB
cord-276456-oa6hh7ky	157	45	both	both	DT
cord-276456-oa6hh7ky	157	46	lipid	lipid	NN
cord-276456-oa6hh7ky	157	47	and	and	CC
cord-276456-oa6hh7ky	157	48	content	content	NN
cord-276456-oa6hh7ky	157	49	mixing	mixing	NN
cord-276456-oa6hh7ky	157	50	.	.	.
cord-276456-oa6hh7ky	158	1	51	51	CD
cord-276456-oa6hh7ky	159	1	As	as	IN
cord-276456-oa6hh7ky	159	2	a	a	DT
cord-276456-oa6hh7ky	159	3	result	result	NN
cord-276456-oa6hh7ky	159	4	of	of	IN
cord-276456-oa6hh7ky	159	5	conformational	conformational	JJ
cord-276456-oa6hh7ky	159	6	changes	change	NNS
cord-276456-oa6hh7ky	159	7	of	of	IN
cord-276456-oa6hh7ky	159	8	HA	HA	NNP
cord-276456-oa6hh7ky	159	9	upon	upon	IN
cord-276456-oa6hh7ky	159	10	low	low	JJ
cord-276456-oa6hh7ky	159	11	pH	pH	NNP
cord-276456-oa6hh7ky	159	12	exposure	exposure	NN
cord-276456-oa6hh7ky	159	13	,	,	,
cord-276456-oa6hh7ky	159	14	the	the	DT
cord-276456-oa6hh7ky	159	15	fusion	fusion	NN
cord-276456-oa6hh7ky	159	16	peptide	peptide	NN
cord-276456-oa6hh7ky	159	17	located	locate	VBN
cord-276456-oa6hh7ky	159	18	at	at	IN
cord-276456-oa6hh7ky	159	19	the	the	DT
cord-276456-oa6hh7ky	159	20	tip	tip	NN
cord-276456-oa6hh7ky	159	21	of	of	IN
cord-276456-oa6hh7ky	159	22	the	the	DT
cord-276456-oa6hh7ky	159	23	HA2	HA2	NNP
cord-276456-oa6hh7ky	159	24	molecule	molecule	NN
cord-276456-oa6hh7ky	159	25	is	be	VBZ
cord-276456-oa6hh7ky	159	26	exposed	expose	VBN
cord-276456-oa6hh7ky	159	27	to	to	IN
cord-276456-oa6hh7ky	159	28	the	the	DT
cord-276456-oa6hh7ky	159	29	close	close	JJ
cord-276456-oa6hh7ky	159	30	proximity	proximity	NN
cord-276456-oa6hh7ky	159	31	of	of	IN
cord-276456-oa6hh7ky	159	32	the	the	DT
cord-276456-oa6hh7ky	159	33	target	target	NN
cord-276456-oa6hh7ky	159	34	membrane	membrane	NN
cord-276456-oa6hh7ky	159	35	.	.	.
cord-276456-oa6hh7ky	160	1	When	when	WRB
cord-276456-oa6hh7ky	160	2	the	the	DT
cord-276456-oa6hh7ky	160	3	target	target	NN
cord-276456-oa6hh7ky	160	4	membrane	membrane	NN
cord-276456-oa6hh7ky	160	5	is	be	VBZ
cord-276456-oa6hh7ky	160	6	available	available	JJ
cord-276456-oa6hh7ky	160	7	,	,	,
cord-276456-oa6hh7ky	160	8	the	the	DT
cord-276456-oa6hh7ky	160	9	fusion	fusion	NN
cord-276456-oa6hh7ky	160	10	peptide	peptide	NN
cord-276456-oa6hh7ky	160	11	inserts	insert	VBZ
cord-276456-oa6hh7ky	160	12	into	into	IN
cord-276456-oa6hh7ky	160	13	the	the	DT
cord-276456-oa6hh7ky	160	14	lipid	lipid	NN
cord-276456-oa6hh7ky	160	15	bilayer	bilayer	NN
cord-276456-oa6hh7ky	160	16	to	to	TO
cord-276456-oa6hh7ky	160	17	induce	induce	VB
cord-276456-oa6hh7ky	160	18	lipid	lipid	NN
cord-276456-oa6hh7ky	160	19	mixing	mix	VBG
cord-276456-oa6hh7ky	160	20	between	between	IN
cord-276456-oa6hh7ky	160	21	the	the	DT
cord-276456-oa6hh7ky	160	22	target	target	NN
cord-276456-oa6hh7ky	160	23	cell	cell	NN
cord-276456-oa6hh7ky	160	24	membrane	membrane	NN
cord-276456-oa6hh7ky	160	25	and	and	CC
cord-276456-oa6hh7ky	160	26	the	the	DT
cord-276456-oa6hh7ky	160	27	viral	viral	JJ
cord-276456-oa6hh7ky	160	28	membrane	membrane	NN
cord-276456-oa6hh7ky	160	29	.	.	.
cord-276456-oa6hh7ky	161	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	161	2	has	have	VBZ
cord-276456-oa6hh7ky	161	3	been	be	VBN
cord-276456-oa6hh7ky	161	4	experimentally	experimentally	RB
cord-276456-oa6hh7ky	161	5	determined	determine	VBN
cord-276456-oa6hh7ky	161	6	that	that	IN
cord-276456-oa6hh7ky	161	7	the	the	DT
cord-276456-oa6hh7ky	161	8	free	free	JJ
cord-276456-oa6hh7ky	161	9	energy	energy	NN
cord-276456-oa6hh7ky	161	10	associated	associate	VBN
cord-276456-oa6hh7ky	161	11	with	with	IN
cord-276456-oa6hh7ky	161	12	the	the	DT
cord-276456-oa6hh7ky	161	13	insertion	insertion	NN
cord-276456-oa6hh7ky	161	14	of	of	IN
cord-276456-oa6hh7ky	161	15	full	full	JJ
cord-276456-oa6hh7ky	161	16	-	-	HYPH
cord-276456-oa6hh7ky	161	17	length	length	NN
cord-276456-oa6hh7ky	161	18	fusion	fusion	NN
cord-276456-oa6hh7ky	161	19	peptide	peptide	NN
cord-276456-oa6hh7ky	161	20	into	into	IN
cord-276456-oa6hh7ky	161	21	the	the	DT
cord-276456-oa6hh7ky	161	22	lipid	lipid	NN
cord-276456-oa6hh7ky	161	23	membrane	membrane	NN
cord-276456-oa6hh7ky	161	24	is	be	VBZ
cord-276456-oa6hh7ky	161	25	4.5	4.5	CD
cord-276456-oa6hh7ky	161	26	kBT	kBT	NNP
cord-276456-oa6hh7ky	161	27	,	,	,
cord-276456-oa6hh7ky	161	28	and	and	CC
cord-276456-oa6hh7ky	161	29	as	as	RB
cord-276456-oa6hh7ky	161	30	many	many	JJ
cord-276456-oa6hh7ky	161	31	as	as	IN
cord-276456-oa6hh7ky	161	32	18	18	CD
cord-276456-oa6hh7ky	161	33	fusion	fusion	NN
cord-276456-oa6hh7ky	161	34	peptides	peptide	NNS
cord-276456-oa6hh7ky	161	35	binding	bind	VBG
cord-276456-oa6hh7ky	161	36	to	to	IN
cord-276456-oa6hh7ky	161	37	the	the	DT
cord-276456-oa6hh7ky	161	38	target	target	NN
cord-276456-oa6hh7ky	161	39	membrane	membrane	NN
cord-276456-oa6hh7ky	161	40	might	may	MD
cord-276456-oa6hh7ky	161	41	generate	generate	VB
cord-276456-oa6hh7ky	161	42	enough	enough	JJ
cord-276456-oa6hh7ky	161	43	energy	energy	NN
cord-276456-oa6hh7ky	161	44	to	to	TO
cord-276456-oa6hh7ky	161	45	stabilize	stabilize	VB
cord-276456-oa6hh7ky	161	46	a	a	DT
cord-276456-oa6hh7ky	161	47	stalk	stalk	NN
cord-276456-oa6hh7ky	161	48	-	-	HYPH
cord-276456-oa6hh7ky	161	49	like	like	JJ
cord-276456-oa6hh7ky	161	50	fusion	fusion	NN
cord-276456-oa6hh7ky	161	51	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	161	52	,	,	,
cord-276456-oa6hh7ky	161	53	which	which	WDT
cord-276456-oa6hh7ky	161	54	has	have	VBZ
cord-276456-oa6hh7ky	161	55	high	high	JJ
cord-276456-oa6hh7ky	161	56	membrane	membrane	NN
cord-276456-oa6hh7ky	161	57	curvature	curvature	NN
cord-276456-oa6hh7ky	161	58	.	.	.
cord-276456-oa6hh7ky	162	1	52	52	CD
cord-276456-oa6hh7ky	163	1	While	while	IN
cord-276456-oa6hh7ky	163	2	necessary	necessary	JJ
cord-276456-oa6hh7ky	163	3	for	for	IN
cord-276456-oa6hh7ky	163	4	fusion	fusion	NN
cord-276456-oa6hh7ky	163	5	,	,	,
cord-276456-oa6hh7ky	163	6	the	the	DT
cord-276456-oa6hh7ky	163	7	packing	packing	NN
cord-276456-oa6hh7ky	163	8	of	of	IN
cord-276456-oa6hh7ky	163	9	fusion	fusion	NN
cord-276456-oa6hh7ky	163	10	peptides	peptide	NNS
cord-276456-oa6hh7ky	163	11	does	do	VBZ
cord-276456-oa6hh7ky	163	12	not	not	RB
cord-276456-oa6hh7ky	163	13	appear	appear	VB
cord-276456-oa6hh7ky	163	14	to	to	TO
cord-276456-oa6hh7ky	163	15	be	be	VB
cord-276456-oa6hh7ky	163	16	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	163	17	for	for	IN
cord-276456-oa6hh7ky	163	18	fusion	fusion	NN
cord-276456-oa6hh7ky	163	19	.	.	.
cord-276456-oa6hh7ky	164	1	Lipids	lipid	NNS
cord-276456-oa6hh7ky	164	2	present	present	JJ
cord-276456-oa6hh7ky	164	3	in	in	IN
cord-276456-oa6hh7ky	164	4	the	the	DT
cord-276456-oa6hh7ky	164	5	membrane	membrane	NN
cord-276456-oa6hh7ky	164	6	act	act	NN
cord-276456-oa6hh7ky	164	7	together	together	RB
cord-276456-oa6hh7ky	164	8	with	with	IN
cord-276456-oa6hh7ky	164	9	HA	HA	NNP
cord-276456-oa6hh7ky	164	10	to	to	TO
cord-276456-oa6hh7ky	164	11	cause	cause	VB
cord-276456-oa6hh7ky	164	12	fusion	fusion	NN
cord-276456-oa6hh7ky	164	13	.	.	.
cord-276456-oa6hh7ky	165	1	Changing	change	VBG
cord-276456-oa6hh7ky	165	2	membrane	membrane	NN
cord-276456-oa6hh7ky	165	3	lipid	lipid	NN
cord-276456-oa6hh7ky	165	4	physical	physical	JJ
cord-276456-oa6hh7ky	165	5	properties	property	NNS
cord-276456-oa6hh7ky	165	6	or	or	CC
cord-276456-oa6hh7ky	165	7	composition	composition	NN
cord-276456-oa6hh7ky	165	8	in	in	IN
cord-276456-oa6hh7ky	165	9	ways	way	NNS
cord-276456-oa6hh7ky	165	10	that	that	WDT
cord-276456-oa6hh7ky	165	11	well	well	RB
cord-276456-oa6hh7ky	165	12	defined	define	VBN
cord-276456-oa6hh7ky	165	13	also	also	RB
cord-276456-oa6hh7ky	165	14	blocks	block	VBZ
cord-276456-oa6hh7ky	165	15	fusion	fusion	NN
cord-276456-oa6hh7ky	165	16	,	,	,
cord-276456-oa6hh7ky	165	17	despite	despite	IN
cord-276456-oa6hh7ky	165	18	conformational	conformational	JJ
cord-276456-oa6hh7ky	165	19	-	-	HYPH
cord-276456-oa6hh7ky	165	20	specific	specific	JJ
cord-276456-oa6hh7ky	165	21	antibody	antibody	NN
cord-276456-oa6hh7ky	165	22	binding	bind	VBG
cord-276456-oa6hh7ky	165	23	indicating	indicate	VBG
cord-276456-oa6hh7ky	165	24	that	that	IN
cord-276456-oa6hh7ky	165	25	HA	HA	NNP
cord-276456-oa6hh7ky	165	26	is	be	VBZ
cord-276456-oa6hh7ky	165	27	in	in	IN
cord-276456-oa6hh7ky	165	28	the	the	DT
cord-276456-oa6hh7ky	165	29	post	post	JJ
cord-276456-oa6hh7ky	165	30	-	-	JJ
cord-276456-oa6hh7ky	165	31	fusion	fusion	JJ
cord-276456-oa6hh7ky	165	32	state	state	NN
cord-276456-oa6hh7ky	165	33	.	.	.
cord-276456-oa6hh7ky	166	1	53	53	CD
cord-276456-oa6hh7ky	167	1	In	in	IN
cord-276456-oa6hh7ky	167	2	other	other	JJ
cord-276456-oa6hh7ky	167	3	words	word	NNS
cord-276456-oa6hh7ky	167	4	the	the	DT
cord-276456-oa6hh7ky	167	5	protein	protein	NN
cord-276456-oa6hh7ky	167	6	conformational	conformational	JJ
cord-276456-oa6hh7ky	167	7	change	change	NN
cord-276456-oa6hh7ky	167	8	,	,	,
cord-276456-oa6hh7ky	167	9	while	while	IN
cord-276456-oa6hh7ky	167	10	essential	essential	JJ
cord-276456-oa6hh7ky	167	11	,	,	,
cord-276456-oa6hh7ky	167	12	is	be	VBZ
cord-276456-oa6hh7ky	167	13	not	not	RB
cord-276456-oa6hh7ky	167	14	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	167	15	,	,	,
cord-276456-oa6hh7ky	167	16	as	as	IN
cord-276456-oa6hh7ky	167	17	there	there	EX
cord-276456-oa6hh7ky	167	18	are	be	VBP
cord-276456-oa6hh7ky	167	19	post	post	JJ
cord-276456-oa6hh7ky	167	20	-	-	JJ
cord-276456-oa6hh7ky	167	21	protein	protein	JJ
cord-276456-oa6hh7ky	167	22	conformational	conformational	JJ
cord-276456-oa6hh7ky	167	23	changes	change	NNS
cord-276456-oa6hh7ky	167	24	in	in	IN
cord-276456-oa6hh7ky	167	25	lipid	lipid	NN
cord-276456-oa6hh7ky	167	26	conformation	conformation	NN
cord-276456-oa6hh7ky	167	27	that	that	WDT
cord-276456-oa6hh7ky	167	28	are	be	VBP
cord-276456-oa6hh7ky	167	29	needed	need	VBN
cord-276456-oa6hh7ky	167	30	for	for	IN
cord-276456-oa6hh7ky	167	31	fusion	fusion	NN
cord-276456-oa6hh7ky	167	32	to	to	TO
cord-276456-oa6hh7ky	167	33	continue	continue	VB
cord-276456-oa6hh7ky	167	34	along	along	IN
cord-276456-oa6hh7ky	167	35	its	-PRON-	PRP$
cord-276456-oa6hh7ky	167	36	path	path	NN
cord-276456-oa6hh7ky	167	37	.	.	.
cord-276456-oa6hh7ky	168	1	Thus	thus	RB
cord-276456-oa6hh7ky	168	2	the	the	DT
cord-276456-oa6hh7ky	168	3	pathway	pathway	NN
cord-276456-oa6hh7ky	168	4	of	of	IN
cord-276456-oa6hh7ky	168	5	HA	HA	NNP
cord-276456-oa6hh7ky	168	6	-	-	HYPH
cord-276456-oa6hh7ky	168	7	mediated	mediate	VBN
cord-276456-oa6hh7ky	168	8	membrane	membrane	NN
cord-276456-oa6hh7ky	168	9	fusion	fusion	NN
cord-276456-oa6hh7ky	168	10	involves	involve	VBZ
cord-276456-oa6hh7ky	168	11	conformational	conformational	JJ
cord-276456-oa6hh7ky	168	12	changes	change	NNS
cord-276456-oa6hh7ky	168	13	to	to	TO
cord-276456-oa6hh7ky	168	14	induce	induce	VB
cord-276456-oa6hh7ky	168	15	lipids	lipid	NNS
cord-276456-oa6hh7ky	168	16	to	to	TO
cord-276456-oa6hh7ky	168	17	undergo	undergo	VB
cord-276456-oa6hh7ky	168	18	the	the	DT
cord-276456-oa6hh7ky	168	19	more	more	RBR
cord-276456-oa6hh7ky	168	20	general	general	JJ
cord-276456-oa6hh7ky	168	21	pathway	pathway	NN
cord-276456-oa6hh7ky	168	22	outlined	outline	VBN
cord-276456-oa6hh7ky	168	23	above	above	RB
cord-276456-oa6hh7ky	168	24	for	for	IN
cord-276456-oa6hh7ky	168	25	lipid	lipid	NN
cord-276456-oa6hh7ky	168	26	membrane	membrane	NN
cord-276456-oa6hh7ky	168	27	fusion	fusion	NN
cord-276456-oa6hh7ky	168	28	.	.	.
cord-276456-oa6hh7ky	169	1	53	53	CD
cord-276456-oa6hh7ky	170	1	The	the	DT
cord-276456-oa6hh7ky	170	2	role	role	NN
cord-276456-oa6hh7ky	170	3	of	of	IN
cord-276456-oa6hh7ky	170	4	the	the	DT
cord-276456-oa6hh7ky	170	5	fusion	fusion	NN
cord-276456-oa6hh7ky	170	6	peptide	peptide	NN
cord-276456-oa6hh7ky	170	7	domain	domain	NN
cord-276456-oa6hh7ky	170	8	for	for	IN
cord-276456-oa6hh7ky	170	9	HA	HA	NNP
cord-276456-oa6hh7ky	170	10	-	-	HYPH
cord-276456-oa6hh7ky	170	11	mediated	mediate	VBN
cord-276456-oa6hh7ky	170	12	membrane	membrane	NN
cord-276456-oa6hh7ky	170	13	fusion	fusion	NN
cord-276456-oa6hh7ky	170	14	has	have	VBZ
cord-276456-oa6hh7ky	170	15	been	be	VBN
cord-276456-oa6hh7ky	170	16	the	the	DT
cord-276456-oa6hh7ky	170	17	subject	subject	NN
cord-276456-oa6hh7ky	170	18	of	of	IN
cord-276456-oa6hh7ky	170	19	many	many	JJ
cord-276456-oa6hh7ky	170	20	biophysical	biophysical	JJ
cord-276456-oa6hh7ky	170	21	studies	study	NNS
cord-276456-oa6hh7ky	170	22	.	.	.
cord-276456-oa6hh7ky	171	1	54	54	CD
cord-276456-oa6hh7ky	172	1	The	the	DT
cord-276456-oa6hh7ky	172	2	fusion	fusion	NN
cord-276456-oa6hh7ky	172	3	peptide	peptide	NN
cord-276456-oa6hh7ky	172	4	of	of	IN
cord-276456-oa6hh7ky	172	5	HA	HA	NNP
cord-276456-oa6hh7ky	172	6	is	be	VBZ
cord-276456-oa6hh7ky	172	7	rich	rich	JJ
cord-276456-oa6hh7ky	172	8	in	in	IN
cord-276456-oa6hh7ky	172	9	glycine	glycine	NN
cord-276456-oa6hh7ky	172	10	;	;	:
cord-276456-oa6hh7ky	172	11	for	for	IN
cord-276456-oa6hh7ky	172	12	example	example	NN
cord-276456-oa6hh7ky	172	13	,	,	,
cord-276456-oa6hh7ky	172	14	influenza	influenza	NN
cord-276456-oa6hh7ky	172	15	A	A	NNP
cord-276456-oa6hh7ky	172	16	/	/	SYM
cord-276456-oa6hh7ky	172	17	X31	X31	NNP
cord-276456-oa6hh7ky	172	18	/	/	SYM
cord-276456-oa6hh7ky	172	19	H3N2	H3N2	NNP
cord-276456-oa6hh7ky	172	20	contains	contain	VBZ
cord-276456-oa6hh7ky	172	21	6	6	CD
cord-276456-oa6hh7ky	172	22	glycine	glycine	NN
cord-276456-oa6hh7ky	172	23	residues	residue	NNS
cord-276456-oa6hh7ky	172	24	in	in	IN
cord-276456-oa6hh7ky	172	25	20	20	CD
cord-276456-oa6hh7ky	172	26	residues	residue	NNS
cord-276456-oa6hh7ky	172	27	of	of	IN
cord-276456-oa6hh7ky	172	28	fusion	fusion	NN
cord-276456-oa6hh7ky	172	29	peptide	peptide	NN
cord-276456-oa6hh7ky	172	30	(	(	-LRB-
cord-276456-oa6hh7ky	172	31	GLFGAIAGFIENGWEGMIDG	GLFGAIAGFIENGWEGMIDG	NNP
cord-276456-oa6hh7ky	172	32	)	)	-RRB-
cord-276456-oa6hh7ky	172	33	.	.	.
cord-276456-oa6hh7ky	173	1	Extensive	extensive	JJ
cord-276456-oa6hh7ky	173	2	mutagenesis	mutagenesis	NN
cord-276456-oa6hh7ky	173	3	studies	study	NNS
cord-276456-oa6hh7ky	173	4	of	of	IN
cord-276456-oa6hh7ky	173	5	fusion	fusion	NN
cord-276456-oa6hh7ky	173	6	peptides	peptide	NNS
cord-276456-oa6hh7ky	173	7	have	have	VBP
cord-276456-oa6hh7ky	173	8	revealed	reveal	VBN
cord-276456-oa6hh7ky	173	9	that	that	IN
cord-276456-oa6hh7ky	173	10	both	both	CC
cord-276456-oa6hh7ky	173	11	the	the	DT
cord-276456-oa6hh7ky	173	12	primary	primary	JJ
cord-276456-oa6hh7ky	173	13	sequence	sequence	NN
cord-276456-oa6hh7ky	173	14	and	and	CC
cord-276456-oa6hh7ky	173	15	the	the	DT
cord-276456-oa6hh7ky	173	16	length	length	NN
cord-276456-oa6hh7ky	173	17	of	of	IN
cord-276456-oa6hh7ky	173	18	fusion	fusion	NN
cord-276456-oa6hh7ky	173	19	peptide	peptide	NN
cord-276456-oa6hh7ky	173	20	are	be	VBP
cord-276456-oa6hh7ky	173	21	crucial	crucial	JJ
cord-276456-oa6hh7ky	173	22	for	for	IN
cord-276456-oa6hh7ky	173	23	HA	HA	NNP
cord-276456-oa6hh7ky	173	24	fusogenic	fusogenic	JJ
cord-276456-oa6hh7ky	173	25	activity	activity	NN
cord-276456-oa6hh7ky	173	26	.	.	.
cord-276456-oa6hh7ky	174	1	55	55	CD
cord-276456-oa6hh7ky	175	1	For	for	IN
cord-276456-oa6hh7ky	175	2	example	example	NN
cord-276456-oa6hh7ky	175	3	,	,	,
cord-276456-oa6hh7ky	175	4	HA2	HA2	NNP
cord-276456-oa6hh7ky	175	5	G1E	G1E	NNP
cord-276456-oa6hh7ky	175	6	substitution	substitution	NN
cord-276456-oa6hh7ky	175	7	abolishes	abolish	VBZ
cord-276456-oa6hh7ky	175	8	cell	cell	NN
cord-276456-oa6hh7ky	175	9	-	-	HYPH
cord-276456-oa6hh7ky	175	10	cell	cell	NN
cord-276456-oa6hh7ky	175	11	and	and	CC
cord-276456-oa6hh7ky	175	12	RBC	RBC	NNP
cord-276456-oa6hh7ky	175	13	-	-	HYPH
cord-276456-oa6hh7ky	175	14	cell	cell	NN
cord-276456-oa6hh7ky	175	15	fusion	fusion	NN
cord-276456-oa6hh7ky	175	16	activity	activity	NN
cord-276456-oa6hh7ky	175	17	of	of	IN
cord-276456-oa6hh7ky	175	18	expressed	express	VBN
cord-276456-oa6hh7ky	175	19	HA	HA	NNP
cord-276456-oa6hh7ky	175	20	,	,	,
cord-276456-oa6hh7ky	175	21	while	while	IN
cord-276456-oa6hh7ky	175	22	G4E	g4e	NN
cord-276456-oa6hh7ky	175	23	substitution	substitution	NN
cord-276456-oa6hh7ky	175	24	decreases	decrease	VBZ
cord-276456-oa6hh7ky	175	25	fusion	fusion	NN
cord-276456-oa6hh7ky	175	26	efficiency	efficiency	NN
cord-276456-oa6hh7ky	175	27	and	and	CC
cord-276456-oa6hh7ky	175	28	elevated	elevate	VBD
cord-276456-oa6hh7ky	175	29	the	the	DT
cord-276456-oa6hh7ky	175	30	pH	pH	NNP
cord-276456-oa6hh7ky	175	31	threshold	threshold	NN
cord-276456-oa6hh7ky	175	32	for	for	IN
cord-276456-oa6hh7ky	175	33	activation	activation	NN
cord-276456-oa6hh7ky	175	34	.	.	.
cord-276456-oa6hh7ky	176	1	56	56	CD
cord-276456-oa6hh7ky	176	2	Alanine	Alanine	NNP
cord-276456-oa6hh7ky	176	3	can	can	MD
cord-276456-oa6hh7ky	176	4	substitute	substitute	VB
cord-276456-oa6hh7ky	176	5	for	for	IN
cord-276456-oa6hh7ky	176	6	glycine	glycine	NN
cord-276456-oa6hh7ky	176	7	at	at	IN
cord-276456-oa6hh7ky	176	8	positions	position	NNS
cord-276456-oa6hh7ky	176	9	1	1	CD
cord-276456-oa6hh7ky	176	10	and	and	CC
cord-276456-oa6hh7ky	176	11	4	4	CD
cord-276456-oa6hh7ky	176	12	without	without	IN
cord-276456-oa6hh7ky	176	13	impacting	impact	VBG
cord-276456-oa6hh7ky	176	14	HA	HA	NNP
cord-276456-oa6hh7ky	176	15	-	-	HYPH
cord-276456-oa6hh7ky	176	16	induced	induce	VBN
cord-276456-oa6hh7ky	176	17	cell	cell	NN
cord-276456-oa6hh7ky	176	18	-	-	HYPH
cord-276456-oa6hh7ky	176	19	cell	cell	NN
cord-276456-oa6hh7ky	176	20	fusion	fusion	NN
cord-276456-oa6hh7ky	176	21	;	;	:
cord-276456-oa6hh7ky	176	22	however	however	RB
cord-276456-oa6hh7ky	176	23	,	,	,
cord-276456-oa6hh7ky	176	24	the	the	DT
cord-276456-oa6hh7ky	176	25	polar	polar	JJ
cord-276456-oa6hh7ky	176	26	amino	amino	NN
cord-276456-oa6hh7ky	176	27	acid	acid	NN
cord-276456-oa6hh7ky	176	28	serine	serine	NN
cord-276456-oa6hh7ky	176	29	substitution	substitution	NN
cord-276456-oa6hh7ky	176	30	for	for	IN
cord-276456-oa6hh7ky	176	31	glycine	glycine	NN
cord-276456-oa6hh7ky	176	32	at	at	IN
cord-276456-oa6hh7ky	176	33	position	position	NN
cord-276456-oa6hh7ky	176	34	1	1	CD
cord-276456-oa6hh7ky	176	35	causes	cause	VBZ
cord-276456-oa6hh7ky	176	36	a	a	DT
cord-276456-oa6hh7ky	176	37	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	176	38	phenotype	phenotype	NN
cord-276456-oa6hh7ky	176	39	.	.	.
cord-276456-oa6hh7ky	177	1	38	38	CD
cord-276456-oa6hh7ky	178	1	The	the	DT
cord-276456-oa6hh7ky	178	2	requirements	requirement	NNS
cord-276456-oa6hh7ky	178	3	for	for	IN
cord-276456-oa6hh7ky	178	4	specific	specific	JJ
cord-276456-oa6hh7ky	178	5	amino	amino	JJ
cord-276456-oa6hh7ky	178	6	acids	acid	NNS
cord-276456-oa6hh7ky	178	7	at	at	IN
cord-276456-oa6hh7ky	178	8	certain	certain	JJ
cord-276456-oa6hh7ky	178	9	positions	position	NNS
cord-276456-oa6hh7ky	178	10	and	and	CC
cord-276456-oa6hh7ky	178	11	for	for	IN
cord-276456-oa6hh7ky	178	12	a	a	DT
cord-276456-oa6hh7ky	178	13	defined	define	VBN
cord-276456-oa6hh7ky	178	14	length	length	NN
cord-276456-oa6hh7ky	178	15	in	in	IN
cord-276456-oa6hh7ky	178	16	the	the	DT
cord-276456-oa6hh7ky	178	17	fusion	fusion	NN
cord-276456-oa6hh7ky	178	18	peptide	peptide	NN
cord-276456-oa6hh7ky	178	19	have	have	VBP
cord-276456-oa6hh7ky	178	20	been	be	VBN
cord-276456-oa6hh7ky	178	21	further	further	RB
cord-276456-oa6hh7ky	178	22	supported	support	VBN
cord-276456-oa6hh7ky	178	23	by	by	IN
cord-276456-oa6hh7ky	178	24	the	the	DT
cord-276456-oa6hh7ky	178	25	NMR	NMR	NNP
cord-276456-oa6hh7ky	178	26	-	-	HYPH
cord-276456-oa6hh7ky	178	27	solved	solve	VBN
cord-276456-oa6hh7ky	178	28	structure	structure	NN
cord-276456-oa6hh7ky	178	29	of	of	IN
cord-276456-oa6hh7ky	178	30	fusion	fusion	NN
cord-276456-oa6hh7ky	178	31	peptide	peptide	NN
cord-276456-oa6hh7ky	178	32	in	in	IN
cord-276456-oa6hh7ky	178	33	detergent	detergent	NN
cord-276456-oa6hh7ky	178	34	micelles	micelle	NNS
cord-276456-oa6hh7ky	178	35	and	and	CC
cord-276456-oa6hh7ky	178	36	in	in	IN
cord-276456-oa6hh7ky	178	37	model	model	NN
cord-276456-oa6hh7ky	178	38	lipid	lipid	NN
cord-276456-oa6hh7ky	178	39	membranes	membrane	NNS
cord-276456-oa6hh7ky	178	40	43,52	43,52	CD
cord-276456-oa6hh7ky	178	41	stabilized	stabilize	VBN
cord-276456-oa6hh7ky	178	42	by	by	IN
cord-276456-oa6hh7ky	178	43	a	a	DT
cord-276456-oa6hh7ky	178	44	charge	charge	NN
cord-276456-oa6hh7ky	178	45	-	-	HYPH
cord-276456-oa6hh7ky	178	46	dipole	dipole	NN
cord-276456-oa6hh7ky	178	47	interaction	interaction	NN
cord-276456-oa6hh7ky	178	48	between	between	IN
cord-276456-oa6hh7ky	178	49	the	the	DT
cord-276456-oa6hh7ky	178	50	N	n	CD
cord-276456-oa6hh7ky	178	51	-	-	HYPH
cord-276456-oa6hh7ky	178	52	terminal	terminal	NN
cord-276456-oa6hh7ky	178	53	Gly	Gly	NNP
cord-276456-oa6hh7ky	178	54	and	and	CC
cord-276456-oa6hh7ky	178	55	the	the	DT
cord-276456-oa6hh7ky	178	56	dipole	dipole	NN
cord-276456-oa6hh7ky	178	57	moment	moment	NN
cord-276456-oa6hh7ky	178	58	of	of	IN
cord-276456-oa6hh7ky	178	59	helix	helix	NN
cord-276456-oa6hh7ky	178	60	2	2	CD
cord-276456-oa6hh7ky	178	61	54	54	CD
cord-276456-oa6hh7ky	179	1	(	(	-LRB-
cord-276456-oa6hh7ky	179	2	Figure	figure	NN
cord-276456-oa6hh7ky	179	3	6	6	CD
cord-276456-oa6hh7ky	179	4	)	)	-RRB-
cord-276456-oa6hh7ky	179	5	.	.	.
cord-276456-oa6hh7ky	180	1	At	at	IN
cord-276456-oa6hh7ky	180	2	acidic	acidic	JJ
cord-276456-oa6hh7ky	180	3	pH	ph	NN
cord-276456-oa6hh7ky	180	4	,	,	,
cord-276456-oa6hh7ky	180	5	the	the	DT
cord-276456-oa6hh7ky	180	6	20	20	CD
cord-276456-oa6hh7ky	180	7	residues	residue	NNS
cord-276456-oa6hh7ky	180	8	of	of	IN
cord-276456-oa6hh7ky	180	9	fusion	fusion	NN
cord-276456-oa6hh7ky	180	10	peptide	peptide	NN
cord-276456-oa6hh7ky	180	11	adopt	adopt	VBP
cord-276456-oa6hh7ky	180	12	a	a	DT
cord-276456-oa6hh7ky	180	13	V	v	NN
cord-276456-oa6hh7ky	180	14	-	-	HYPH
cord-276456-oa6hh7ky	180	15	shaped	shape	VBN
cord-276456-oa6hh7ky	180	16	'	'	''
cord-276456-oa6hh7ky	180	17	boomerang	boomerang	NN
cord-276456-oa6hh7ky	180	18	'	'	''
cord-276456-oa6hh7ky	180	19	structure	structure	NN
cord-276456-oa6hh7ky	180	20	with	with	IN
cord-276456-oa6hh7ky	180	21	an	an	DT
cord-276456-oa6hh7ky	180	22	oblique	oblique	JJ
cord-276456-oa6hh7ky	180	23	NH	NH	NNP
cord-276456-oa6hh7ky	180	24	2	2	CD
cord-276456-oa6hh7ky	180	25	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	180	26	amphipathic	amphipathic	NNP
cord-276456-oa6hh7ky	180	27	helix	helix	NNP
cord-276456-oa6hh7ky	180	28	spanning	span	VBG
cord-276456-oa6hh7ky	180	29	residues	residue	NNS
cord-276456-oa6hh7ky	180	30	2	2	CD
cord-276456-oa6hh7ky	180	31	-	-	SYM
cord-276456-oa6hh7ky	180	32	10	10	CD
cord-276456-oa6hh7ky	180	33	and	and	CC
cord-276456-oa6hh7ky	180	34	a	a	DT
cord-276456-oa6hh7ky	180	35	turn	turn	NN
cord-276456-oa6hh7ky	180	36	formed	form	VBN
cord-276456-oa6hh7ky	180	37	by	by	IN
cord-276456-oa6hh7ky	180	38	residues	residue	NNS
cord-276456-oa6hh7ky	180	39	11	11	CD
cord-276456-oa6hh7ky	180	40	,	,	,
cord-276456-oa6hh7ky	180	41	12	12	CD
cord-276456-oa6hh7ky	180	42	and	and	CC
cord-276456-oa6hh7ky	180	43	13	13	CD
cord-276456-oa6hh7ky	180	44	followed	follow	VBN
cord-276456-oa6hh7ky	180	45	by	by	IN
cord-276456-oa6hh7ky	180	46	a	a	DT
cord-276456-oa6hh7ky	180	47	short	short	JJ
cord-276456-oa6hh7ky	180	48	COOH	COOH	NNP
cord-276456-oa6hh7ky	180	49	-	-	HYPH
cord-276456-oa6hh7ky	180	50	terminal	terminal	NN
cord-276456-oa6hh7ky	180	51	helix	helix	NN
cord-276456-oa6hh7ky	180	52	43	43	CD
cord-276456-oa6hh7ky	180	53	,	,	,
cord-276456-oa6hh7ky	180	54	57	57	CD
cord-276456-oa6hh7ky	180	55	stabilized	stabilize	VBN
cord-276456-oa6hh7ky	180	56	by	by	IN
cord-276456-oa6hh7ky	180	57	a	a	DT
cord-276456-oa6hh7ky	180	58	charge	charge	NN
cord-276456-oa6hh7ky	180	59	-	-	HYPH
cord-276456-oa6hh7ky	180	60	dipole	dipole	NN
cord-276456-oa6hh7ky	180	61	interaction	interaction	NN
cord-276456-oa6hh7ky	180	62	between	between	IN
cord-276456-oa6hh7ky	180	63	the	the	DT
cord-276456-oa6hh7ky	180	64	Nterminal	Nterminal	NNP
cord-276456-oa6hh7ky	180	65	Gly	Gly	NNP
cord-276456-oa6hh7ky	180	66	and	and	CC
cord-276456-oa6hh7ky	180	67	the	the	DT
cord-276456-oa6hh7ky	180	68	dipole	dipole	NN
cord-276456-oa6hh7ky	180	69	moment	moment	NN
cord-276456-oa6hh7ky	180	70	of	of	IN
cord-276456-oa6hh7ky	180	71	helix	helix	NN
cord-276456-oa6hh7ky	180	72	2	2	CD
cord-276456-oa6hh7ky	180	73	58	58	CD
cord-276456-oa6hh7ky	181	1	(	(	-LRB-
cord-276456-oa6hh7ky	181	2	Figure	figure	NN
cord-276456-oa6hh7ky	181	3	6	6	CD
cord-276456-oa6hh7ky	181	4	)	)	-RRB-
cord-276456-oa6hh7ky	181	5	.	.	.
cord-276456-oa6hh7ky	182	1	The	the	DT
cord-276456-oa6hh7ky	182	2	bent	bent	JJ
cord-276456-oa6hh7ky	182	3	fusion	fusion	NN
cord-276456-oa6hh7ky	182	4	peptide	peptide	NN
cord-276456-oa6hh7ky	182	5	then	then	RB
cord-276456-oa6hh7ky	182	6	may	may	MD
cord-276456-oa6hh7ky	182	7	insert	insert	VB
cord-276456-oa6hh7ky	182	8	B16	B16	NNP
cord-276456-oa6hh7ky	182	9	-	-	HYPH
cord-276456-oa6hh7ky	182	10	17	17	CD
cord-276456-oa6hh7ky	182	11	Å	å	NN
cord-276456-oa6hh7ky	182	12	into	into	IN
cord-276456-oa6hh7ky	182	13	the	the	DT
cord-276456-oa6hh7ky	182	14	outer	outer	JJ
cord-276456-oa6hh7ky	182	15	leaflet	leaflet	NN
cord-276456-oa6hh7ky	182	16	of	of	IN
cord-276456-oa6hh7ky	182	17	the	the	DT
cord-276456-oa6hh7ky	182	18	target	target	NN
cord-276456-oa6hh7ky	182	19	membrane	membrane	NN
cord-276456-oa6hh7ky	182	20	,	,	,
cord-276456-oa6hh7ky	182	21	almost	almost	RB
cord-276456-oa6hh7ky	182	22	to	to	IN
cord-276456-oa6hh7ky	182	23	the	the	DT
cord-276456-oa6hh7ky	182	24	mid	mid	NN
cord-276456-oa6hh7ky	182	25	-	-	NN
cord-276456-oa6hh7ky	182	26	plane	plane	NN
cord-276456-oa6hh7ky	182	27	of	of	IN
cord-276456-oa6hh7ky	182	28	the	the	DT
cord-276456-oa6hh7ky	182	29	lipid	lipid	NN
cord-276456-oa6hh7ky	182	30	bilayer	bilayer	NN
cord-276456-oa6hh7ky	182	31	with	with	IN
cord-276456-oa6hh7ky	182	32	the	the	DT
cord-276456-oa6hh7ky	182	33	residue	residue	NN
cord-276456-oa6hh7ky	182	34	Leu	Leu	NNP
cord-276456-oa6hh7ky	182	35	2	2	CD
cord-276456-oa6hh7ky	182	36	and	and	CC
cord-276456-oa6hh7ky	182	37	Phe	Phe	NNP
cord-276456-oa6hh7ky	182	38	3	3	CD
cord-276456-oa6hh7ky	182	39	penetrating	penetrate	VBG
cord-276456-oa6hh7ky	182	40	deepest	deepest	RBS
cord-276456-oa6hh7ky	182	41	into	into	IN
cord-276456-oa6hh7ky	182	42	the	the	DT
cord-276456-oa6hh7ky	182	43	membrane	membrane	NN
cord-276456-oa6hh7ky	182	44	.	.	.
cord-276456-oa6hh7ky	183	1	52	52	CD
cord-276456-oa6hh7ky	183	2	,	,	,
cord-276456-oa6hh7ky	183	3	57	57	CD
cord-276456-oa6hh7ky	184	1	In	in	IN
cord-276456-oa6hh7ky	184	2	the	the	DT
cord-276456-oa6hh7ky	184	3	solution	solution	NN
cord-276456-oa6hh7ky	184	4	structure	structure	NN
cord-276456-oa6hh7ky	184	5	,	,	,
cord-276456-oa6hh7ky	184	6	the	the	DT
cord-276456-oa6hh7ky	184	7	hemifusion	hemifusion	NNP
cord-276456-oa6hh7ky	184	8	phenotype	phenotype	NN
cord-276456-oa6hh7ky	184	9	mutant	mutant	NNP
cord-276456-oa6hh7ky	184	10	G1S	G1S	NNP
cord-276456-oa6hh7ky	184	11	has	have	VBZ
cord-276456-oa6hh7ky	184	12	a	a	DT
cord-276456-oa6hh7ky	184	13	similar	similar	JJ
cord-276456-oa6hh7ky	184	14	structure	structure	NN
cord-276456-oa6hh7ky	184	15	to	to	IN
cord-276456-oa6hh7ky	184	16	that	that	DT
cord-276456-oa6hh7ky	184	17	of	of	IN
cord-276456-oa6hh7ky	184	18	wild	wild	JJ
cord-276456-oa6hh7ky	184	19	type	type	NN
cord-276456-oa6hh7ky	184	20	,	,	,
cord-276456-oa6hh7ky	184	21	but	but	CC
cord-276456-oa6hh7ky	184	22	the	the	DT
cord-276456-oa6hh7ky	184	23	glycine	glycine	NN
cord-276456-oa6hh7ky	184	24	ridge	ridge	NN
cord-276456-oa6hh7ky	184	25	on	on	IN
cord-276456-oa6hh7ky	184	26	the	the	DT
cord-276456-oa6hh7ky	184	27	outer	outer	JJ
cord-276456-oa6hh7ky	184	28	surface	surface	NN
cord-276456-oa6hh7ky	184	29	of	of	IN
cord-276456-oa6hh7ky	184	30	the	the	DT
cord-276456-oa6hh7ky	184	31	NH	NH	NNP
cord-276456-oa6hh7ky	184	32	2	2	CD
cord-276456-oa6hh7ky	184	33	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	184	34	helical	helical	JJ
cord-276456-oa6hh7ky	184	35	arm	arm	NN
cord-276456-oa6hh7ky	184	36	is	be	VBZ
cord-276456-oa6hh7ky	184	37	disrupted	disrupt	VBN
cord-276456-oa6hh7ky	184	38	.	.	.
cord-276456-oa6hh7ky	185	1	In	in	IN
cord-276456-oa6hh7ky	185	2	contrast	contrast	NN
cord-276456-oa6hh7ky	185	3	,	,	,
cord-276456-oa6hh7ky	185	4	the	the	DT
cord-276456-oa6hh7ky	185	5	mutant	mutant	JJ
cord-276456-oa6hh7ky	185	6	G1V	g1v	NN
cord-276456-oa6hh7ky	185	7	,	,	,
cord-276456-oa6hh7ky	185	8	where	where	WRB
cord-276456-oa6hh7ky	185	9	fusion	fusion	NN
cord-276456-oa6hh7ky	185	10	is	be	VBZ
cord-276456-oa6hh7ky	185	11	completely	completely	RB
cord-276456-oa6hh7ky	185	12	abolished	abolish	VBN
cord-276456-oa6hh7ky	185	13	,	,	,
cord-276456-oa6hh7ky	185	14	has	have	VBZ
cord-276456-oa6hh7ky	185	15	a	a	DT
cord-276456-oa6hh7ky	185	16	very	very	RB
cord-276456-oa6hh7ky	185	17	irregular	irregular	JJ
cord-276456-oa6hh7ky	185	18	linear	linear	JJ
cord-276456-oa6hh7ky	185	19	amphipathic	amphipathic	JJ
cord-276456-oa6hh7ky	185	20	helix	helix	NN
cord-276456-oa6hh7ky	185	21	instead	instead	RB
cord-276456-oa6hh7ky	185	22	of	of	IN
cord-276456-oa6hh7ky	185	23	the	the	DT
cord-276456-oa6hh7ky	185	24	fixed	fixed	JJ
cord-276456-oa6hh7ky	185	25	angled	angled	JJ
cord-276456-oa6hh7ky	185	26	boomerang	boomerang	NN
cord-276456-oa6hh7ky	185	27	structure	structure	NN
cord-276456-oa6hh7ky	185	28	(	(	-LRB-
cord-276456-oa6hh7ky	185	29	Figure	Figure	NNP
cord-276456-oa6hh7ky	185	30	6	6	CD
cord-276456-oa6hh7ky	185	31	)	)	-RRB-
cord-276456-oa6hh7ky	185	32	.	.	.
cord-276456-oa6hh7ky	186	1	59,60	59,60	CD
cord-276456-oa6hh7ky	187	1	Another	another	DT
cord-276456-oa6hh7ky	187	2	fusion	fusion	NN
cord-276456-oa6hh7ky	187	3	-	-	HYPH
cord-276456-oa6hh7ky	187	4	defective	defective	JJ
cord-276456-oa6hh7ky	187	5	mutant	mutant	NN
cord-276456-oa6hh7ky	187	6	,	,	,
cord-276456-oa6hh7ky	187	7	W14A	W14A	NNP
cord-276456-oa6hh7ky	187	8	,	,	,
cord-276456-oa6hh7ky	187	9	has	have	VBZ
cord-276456-oa6hh7ky	187	10	a	a	DT
cord-276456-oa6hh7ky	187	11	more	more	RBR
cord-276456-oa6hh7ky	187	12	flexible	flexible	JJ
cord-276456-oa6hh7ky	187	13	kink	kink	NN
cord-276456-oa6hh7ky	187	14	than	than	IN
cord-276456-oa6hh7ky	187	15	that	that	DT
cord-276456-oa6hh7ky	187	16	of	of	IN
cord-276456-oa6hh7ky	187	17	the	the	DT
cord-276456-oa6hh7ky	187	18	wild	wild	JJ
cord-276456-oa6hh7ky	187	19	type	type	NN
cord-276456-oa6hh7ky	187	20	,	,	,
cord-276456-oa6hh7ky	187	21	in	in	IN
cord-276456-oa6hh7ky	187	22	contrast	contrast	NN
cord-276456-oa6hh7ky	187	23	,	,	,
cord-276456-oa6hh7ky	187	24	the	the	DT
cord-276456-oa6hh7ky	187	25	alanine	alanine	JJ
cord-276456-oa6hh7ky	187	26	substitution	substitution	NN
cord-276456-oa6hh7ky	187	27	at	at	IN
cord-276456-oa6hh7ky	187	28	phenylalanine	phenylalanine	NN
cord-276456-oa6hh7ky	187	29	residue	residue	NN
cord-276456-oa6hh7ky	187	30	9	9	CD
cord-276456-oa6hh7ky	187	31	(	(	-LRB-
cord-276456-oa6hh7ky	187	32	F9A	F9A	NNP
cord-276456-oa6hh7ky	187	33	)	)	-RRB-
cord-276456-oa6hh7ky	187	34	has	have	VBZ
cord-276456-oa6hh7ky	187	35	a	a	DT
cord-276456-oa6hh7ky	187	36	similar	similar	JJ
cord-276456-oa6hh7ky	187	37	structure	structure	NN
cord-276456-oa6hh7ky	187	38	to	to	IN
cord-276456-oa6hh7ky	187	39	that	that	DT
cord-276456-oa6hh7ky	187	40	of	of	IN
cord-276456-oa6hh7ky	187	41	the	the	DT
cord-276456-oa6hh7ky	187	42	wild	wild	JJ
cord-276456-oa6hh7ky	187	43	-	-	HYPH
cord-276456-oa6hh7ky	187	44	type	type	NN
cord-276456-oa6hh7ky	187	45	and	and	CC
cord-276456-oa6hh7ky	187	46	has	have	VBZ
cord-276456-oa6hh7ky	187	47	no	no	DT
cord-276456-oa6hh7ky	187	48	defect	defect	NN
cord-276456-oa6hh7ky	187	49	in	in	IN
cord-276456-oa6hh7ky	187	50	fusion	fusion	NN
cord-276456-oa6hh7ky	187	51	(	(	-LRB-
cord-276456-oa6hh7ky	187	52	Figure	figure	NN
cord-276456-oa6hh7ky	187	53	6	6	CD
cord-276456-oa6hh7ky	187	54	)	)	-RRB-
cord-276456-oa6hh7ky	187	55	.	.	.
cord-276456-oa6hh7ky	188	1	61	61	CD
cord-276456-oa6hh7ky	189	1	These	these	DT
cord-276456-oa6hh7ky	189	2	studies	study	NNS
cord-276456-oa6hh7ky	189	3	suggest	suggest	VBP
cord-276456-oa6hh7ky	189	4	that	that	IN
cord-276456-oa6hh7ky	189	5	both	both	PDT
cord-276456-oa6hh7ky	189	6	the	the	DT
cord-276456-oa6hh7ky	189	7	angled	angled	JJ
cord-276456-oa6hh7ky	189	8	and	and	CC
cord-276456-oa6hh7ky	189	9	deeply	deeply	RB
cord-276456-oa6hh7ky	189	10	inserted	insert	VBN
cord-276456-oa6hh7ky	189	11	structure	structure	NN
cord-276456-oa6hh7ky	189	12	as	as	RB
cord-276456-oa6hh7ky	189	13	well	well	RB
cord-276456-oa6hh7ky	189	14	as	as	IN
cord-276456-oa6hh7ky	189	15	the	the	DT
cord-276456-oa6hh7ky	189	16	glycine	glycine	NNP
cord-276456-oa6hh7ky	189	17	ridge	ridge	NNP
cord-276456-oa6hh7ky	189	18	make	make	VBP
cord-276456-oa6hh7ky	189	19	a	a	DT
cord-276456-oa6hh7ky	189	20	contribution	contribution	NN
cord-276456-oa6hh7ky	189	21	to	to	IN
cord-276456-oa6hh7ky	189	22	the	the	DT
cord-276456-oa6hh7ky	189	23	fusion	fusion	NN
cord-276456-oa6hh7ky	189	24	activity	activity	NN
cord-276456-oa6hh7ky	189	25	.	.	.
cord-276456-oa6hh7ky	190	1	Despite	despite	IN
cord-276456-oa6hh7ky	190	2	the	the	DT
cord-276456-oa6hh7ky	190	3	fact	fact	NN
cord-276456-oa6hh7ky	190	4	that	that	IN
cord-276456-oa6hh7ky	190	5	we	-PRON-	PRP
cord-276456-oa6hh7ky	190	6	have	have	VBP
cord-276456-oa6hh7ky	190	7	gained	gain	VBN
cord-276456-oa6hh7ky	190	8	a	a	DT
cord-276456-oa6hh7ky	190	9	large	large	JJ
cord-276456-oa6hh7ky	190	10	amount	amount	NN
cord-276456-oa6hh7ky	190	11	of	of	IN
cord-276456-oa6hh7ky	190	12	information	information	NN
cord-276456-oa6hh7ky	190	13	on	on	IN
cord-276456-oa6hh7ky	190	14	the	the	DT
cord-276456-oa6hh7ky	190	15	structure	structure	NN
cord-276456-oa6hh7ky	190	16	of	of	IN
cord-276456-oa6hh7ky	190	17	the	the	DT
cord-276456-oa6hh7ky	190	18	influenza	influenza	NN
cord-276456-oa6hh7ky	190	19	fusion	fusion	NN
cord-276456-oa6hh7ky	190	20	peptide	peptide	NN
cord-276456-oa6hh7ky	190	21	over	over	IN
cord-276456-oa6hh7ky	190	22	the	the	DT
cord-276456-oa6hh7ky	190	23	past	past	JJ
cord-276456-oa6hh7ky	190	24	several	several	JJ
cord-276456-oa6hh7ky	190	25	years	year	NNS
cord-276456-oa6hh7ky	190	26	,	,	,
cord-276456-oa6hh7ky	190	27	there	there	EX
cord-276456-oa6hh7ky	190	28	are	be	VBP
cord-276456-oa6hh7ky	190	29	still	still	RB
cord-276456-oa6hh7ky	190	30	open	open	JJ
cord-276456-oa6hh7ky	190	31	questions	question	NNS
cord-276456-oa6hh7ky	190	32	surrounding	surround	VBG
cord-276456-oa6hh7ky	190	33	how	how	WRB
cord-276456-oa6hh7ky	190	34	the	the	DT
cord-276456-oa6hh7ky	190	35	insertion	insertion	NN
cord-276456-oa6hh7ky	190	36	of	of	IN
cord-276456-oa6hh7ky	190	37	fusion	fusion	NN
cord-276456-oa6hh7ky	190	38	peptide	peptide	NN
cord-276456-oa6hh7ky	190	39	leads	lead	VBZ
cord-276456-oa6hh7ky	190	40	to	to	IN
cord-276456-oa6hh7ky	190	41	fusion	fusion	NN
cord-276456-oa6hh7ky	190	42	of	of	IN
cord-276456-oa6hh7ky	190	43	viral	viral	JJ
cord-276456-oa6hh7ky	190	44	membrane	membrane	NN
cord-276456-oa6hh7ky	190	45	and	and	CC
cord-276456-oa6hh7ky	190	46	target	target	NN
cord-276456-oa6hh7ky	190	47	membrane	membrane	NN
cord-276456-oa6hh7ky	190	48	and	and	CC
cord-276456-oa6hh7ky	190	49	also	also	RB
cord-276456-oa6hh7ky	190	50	with	with	IN
cord-276456-oa6hh7ky	190	51	regard	regard	NN
cord-276456-oa6hh7ky	190	52	to	to	IN
cord-276456-oa6hh7ky	190	53	the	the	DT
cord-276456-oa6hh7ky	190	54	thermodynamic	thermodynamic	JJ
cord-276456-oa6hh7ky	190	55	profile	profile	NN
cord-276456-oa6hh7ky	190	56	during	during	IN
cord-276456-oa6hh7ky	190	57	the	the	DT
cord-276456-oa6hh7ky	190	58	mixing	mixing	NN
cord-276456-oa6hh7ky	190	59	of	of	IN
cord-276456-oa6hh7ky	190	60	two	two	CD
cord-276456-oa6hh7ky	190	61	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	190	62	.	.	.
cord-276456-oa6hh7ky	191	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	191	2	has	have	VBZ
cord-276456-oa6hh7ky	191	3	been	be	VBN
cord-276456-oa6hh7ky	191	4	generally	generally	RB
cord-276456-oa6hh7ky	191	5	accepted	accept	VBN
cord-276456-oa6hh7ky	191	6	that	that	IN
cord-276456-oa6hh7ky	191	7	the	the	DT
cord-276456-oa6hh7ky	191	8	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	191	9	domain	domain	NN
cord-276456-oa6hh7ky	191	10	(	(	-LRB-
cord-276456-oa6hh7ky	191	11	TMD	TMD	NNP
cord-276456-oa6hh7ky	191	12	)	)	-RRB-
cord-276456-oa6hh7ky	191	13	of	of	IN
cord-276456-oa6hh7ky	191	14	HA2	HA2	NNP
cord-276456-oa6hh7ky	191	15	and	and	CC
cord-276456-oa6hh7ky	191	16	cooperation	cooperation	NN
cord-276456-oa6hh7ky	191	17	of	of	IN
cord-276456-oa6hh7ky	191	18	multiple	multiple	JJ
cord-276456-oa6hh7ky	191	19	HA	HA	NNP
cord-276456-oa6hh7ky	191	20	molecules	molecule	NNS
cord-276456-oa6hh7ky	191	21	are	be	VBP
cord-276456-oa6hh7ky	191	22	required	require	VBN
cord-276456-oa6hh7ky	191	23	in	in	IN
cord-276456-oa6hh7ky	191	24	the	the	DT
cord-276456-oa6hh7ky	191	25	fusion	fusion	NN
cord-276456-oa6hh7ky	191	26	pore	pore	NN
cord-276456-oa6hh7ky	191	27	initiation	initiation	NN
cord-276456-oa6hh7ky	191	28	and	and	CC
cord-276456-oa6hh7ky	191	29	fusion	fusion	NN
cord-276456-oa6hh7ky	191	30	pore	pore	NN
cord-276456-oa6hh7ky	191	31	enlargement	enlargement	NN
cord-276456-oa6hh7ky	191	32	.	.	.
cord-276456-oa6hh7ky	192	1	62	62	CD
cord-276456-oa6hh7ky	193	1	Replacing	replace	VBG
cord-276456-oa6hh7ky	193	2	the	the	DT
cord-276456-oa6hh7ky	193	3	TMD	TMD	NNP
cord-276456-oa6hh7ky	193	4	of	of	IN
cord-276456-oa6hh7ky	193	5	HA	HA	NNP
cord-276456-oa6hh7ky	193	6	with	with	IN
cord-276456-oa6hh7ky	193	7	a	a	DT
cord-276456-oa6hh7ky	193	8	glycerylphosphatidylinositol	glycerylphosphatidylinositol	NN
cord-276456-oa6hh7ky	193	9	(	(	-LRB-
cord-276456-oa6hh7ky	193	10	GPI	GPI	NNP
cord-276456-oa6hh7ky	193	11	)	)	-RRB-
cord-276456-oa6hh7ky	193	12	anchor	anchor	NN
cord-276456-oa6hh7ky	193	13	or	or	CC
cord-276456-oa6hh7ky	193	14	the	the	DT
cord-276456-oa6hh7ky	193	15	deletion	deletion	NN
cord-276456-oa6hh7ky	193	16	mutants	mutant	NNS
cord-276456-oa6hh7ky	193	17	with	with	IN
cord-276456-oa6hh7ky	193	18	less	less	JJR
cord-276456-oa6hh7ky	193	19	than	than	IN
cord-276456-oa6hh7ky	193	20	17	17	CD
cord-276456-oa6hh7ky	193	21	residues	residue	NNS
cord-276456-oa6hh7ky	193	22	in	in	IN
cord-276456-oa6hh7ky	193	23	length	length	NN
cord-276456-oa6hh7ky	193	24	cause	cause	VB
cord-276456-oa6hh7ky	193	25	a	a	DT
cord-276456-oa6hh7ky	193	26	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	193	27	phenotype	phenotype	NN
cord-276456-oa6hh7ky	193	28	,	,	,
cord-276456-oa6hh7ky	193	29	but	but	CC
cord-276456-oa6hh7ky	193	30	a	a	DT
cord-276456-oa6hh7ky	193	31	TMD	TMD	NNP
cord-276456-oa6hh7ky	193	32	with	with	IN
cord-276456-oa6hh7ky	193	33	polar	polar	JJ
cord-276456-oa6hh7ky	193	34	amino	amino	NN
cord-276456-oa6hh7ky	193	35	acids	acid	NNS
cord-276456-oa6hh7ky	193	36	at	at	IN
cord-276456-oa6hh7ky	193	37	the	the	DT
cord-276456-oa6hh7ky	193	38	COOHterminus	COOHterminus	NNP
cord-276456-oa6hh7ky	193	39	still	still	RB
cord-276456-oa6hh7ky	193	40	allows	allow	VBZ
cord-276456-oa6hh7ky	193	41	full	full	JJ
cord-276456-oa6hh7ky	193	42	fusion	fusion	NN
cord-276456-oa6hh7ky	193	43	.	.	.
cord-276456-oa6hh7ky	194	1	12,63	12,63	CD
cord-276456-oa6hh7ky	195	1	A	a	DT
cord-276456-oa6hh7ky	195	2	synthetic	synthetic	JJ
cord-276456-oa6hh7ky	195	3	peptide	peptide	NN
cord-276456-oa6hh7ky	195	4	representing	represent	VBG
cord-276456-oa6hh7ky	195	5	the	the	DT
cord-276456-oa6hh7ky	195	6	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	195	7	segment	segment	NN
cord-276456-oa6hh7ky	195	8	of	of	IN
cord-276456-oa6hh7ky	195	9	X31	X31	NNP
cord-276456-oa6hh7ky	195	10	/	/	SYM
cord-276456-oa6hh7ky	195	11	HA	HA	NNP
cord-276456-oa6hh7ky	195	12	spans	span	VBZ
cord-276456-oa6hh7ky	195	13	an	an	DT
cord-276456-oa6hh7ky	195	14	artificial	artificial	JJ
cord-276456-oa6hh7ky	195	15	DMPC	DMPC	NNP
cord-276456-oa6hh7ky	195	16	/	/	SYM
cord-276456-oa6hh7ky	195	17	DMPG	DMPG	NNP
cord-276456-oa6hh7ky	195	18	bilayer	bilayer	NN
cord-276456-oa6hh7ky	195	19	as	as	IN
cord-276456-oa6hh7ky	195	20	an	an	DT
cord-276456-oa6hh7ky	195	21	a	a	DT
cord-276456-oa6hh7ky	195	22	-	-	HYPH
cord-276456-oa6hh7ky	195	23	helix	helix	NN
cord-276456-oa6hh7ky	195	24	that	that	WDT
cord-276456-oa6hh7ky	195	25	aligns	align	VBZ
cord-276456-oa6hh7ky	195	26	roughly	roughly	RB
cord-276456-oa6hh7ky	195	27	perpendicular	perpendicular	JJ
cord-276456-oa6hh7ky	195	28	to	to	IN
cord-276456-oa6hh7ky	195	29	the	the	DT
cord-276456-oa6hh7ky	195	30	bilayer	bilayer	NN
cord-276456-oa6hh7ky	195	31	membrane	membrane	NN
cord-276456-oa6hh7ky	195	32	.	.	.
cord-276456-oa6hh7ky	196	1	The	the	DT
cord-276456-oa6hh7ky	196	2	consequences	consequence	NNS
cord-276456-oa6hh7ky	196	3	of	of	IN
cord-276456-oa6hh7ky	196	4	HA	HA	NNP
cord-276456-oa6hh7ky	196	5	fusion	fusion	NN
cord-276456-oa6hh7ky	196	6	peptide	peptide	NN
cord-276456-oa6hh7ky	196	7	insertion	insertion	NN
cord-276456-oa6hh7ky	196	8	are	be	VBP
cord-276456-oa6hh7ky	196	9	not	not	RB
cord-276456-oa6hh7ky	196	10	well	well	RB
cord-276456-oa6hh7ky	196	11	understood	understand	VBN
cord-276456-oa6hh7ky	196	12	,	,	,
cord-276456-oa6hh7ky	196	13	although	although	IN
cord-276456-oa6hh7ky	196	14	it	-PRON-	PRP
cord-276456-oa6hh7ky	196	15	is	be	VBZ
cord-276456-oa6hh7ky	196	16	clear	clear	JJ
cord-276456-oa6hh7ky	196	17	that	that	IN
cord-276456-oa6hh7ky	196	18	the	the	DT
cord-276456-oa6hh7ky	196	19	proposed	propose	VBN
cord-276456-oa6hh7ky	196	20	boomerang	boomerang	NN
cord-276456-oa6hh7ky	196	21	structure	structure	NN
cord-276456-oa6hh7ky	196	22	avoids	avoid	VBZ
cord-276456-oa6hh7ky	196	23	placing	place	VBG
cord-276456-oa6hh7ky	196	24	the	the	DT
cord-276456-oa6hh7ky	196	25	polar	polar	JJ
cord-276456-oa6hh7ky	196	26	amino	amino	NN
cord-276456-oa6hh7ky	196	27	acids	acid	NNS
cord-276456-oa6hh7ky	196	28	within	within	IN
cord-276456-oa6hh7ky	196	29	the	the	DT
cord-276456-oa6hh7ky	196	30	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	196	31	phase	phase	NN
cord-276456-oa6hh7ky	196	32	,	,	,
cord-276456-oa6hh7ky	196	33	which	which	WDT
cord-276456-oa6hh7ky	196	34	would	would	MD
cord-276456-oa6hh7ky	196	35	be	be	VB
cord-276456-oa6hh7ky	196	36	disruptive	disruptive	JJ
cord-276456-oa6hh7ky	196	37	or	or	CC
cord-276456-oa6hh7ky	196	38	structure	structure	NN
cord-276456-oa6hh7ky	196	39	-	-	HYPH
cord-276456-oa6hh7ky	196	40	forming	form	VBG
cord-276456-oa6hh7ky	196	41	.	.	.
cord-276456-oa6hh7ky	197	1	Insertion	insertion	NN
cord-276456-oa6hh7ky	197	2	of	of	IN
cord-276456-oa6hh7ky	197	3	a	a	DT
cord-276456-oa6hh7ky	197	4	charged	charge	VBN
cord-276456-oa6hh7ky	197	5	amphipathic	amphipathic	JJ
cord-276456-oa6hh7ky	197	6	helix	helix	NN
cord-276456-oa6hh7ky	197	7	per	per	FW
cord-276456-oa6hh7ky	197	8	se	se	FW
cord-276456-oa6hh7ky	197	9	would	would	MD
cord-276456-oa6hh7ky	197	10	tend	tend	VB
cord-276456-oa6hh7ky	197	11	to	to	TO
cord-276456-oa6hh7ky	197	12	promote	promote	VB
cord-276456-oa6hh7ky	197	13	positive	positive	JJ
cord-276456-oa6hh7ky	197	14	curvature	curvature	NN
cord-276456-oa6hh7ky	197	15	,	,	,
cord-276456-oa6hh7ky	197	16	and	and	CC
cord-276456-oa6hh7ky	197	17	might	may	MD
cord-276456-oa6hh7ky	197	18	aid	aid	VB
cord-276456-oa6hh7ky	197	19	in	in	IN
cord-276456-oa6hh7ky	197	20	'	'	''
cord-276456-oa6hh7ky	197	21	'	'	``
cord-276456-oa6hh7ky	197	22	nippling	nippling	NN
cord-276456-oa6hh7ky	197	23	'	'	''
cord-276456-oa6hh7ky	197	24	'	'	''
cord-276456-oa6hh7ky	197	25	the	the	DT
cord-276456-oa6hh7ky	197	26	membranes	membrane	NNS
cord-276456-oa6hh7ky	197	27	towards	towards	IN
cord-276456-oa6hh7ky	197	28	each	each	DT
cord-276456-oa6hh7ky	197	29	other	other	JJ
cord-276456-oa6hh7ky	197	30	to	to	TO
cord-276456-oa6hh7ky	197	31	contact	contact	VB
cord-276456-oa6hh7ky	197	32	prior	prior	RB
cord-276456-oa6hh7ky	197	33	to	to	IN
cord-276456-oa6hh7ky	197	34	fusion	fusion	NN
cord-276456-oa6hh7ky	197	35	,	,	,
cord-276456-oa6hh7ky	197	36	as	as	IN
cord-276456-oa6hh7ky	197	37	in	in	IN
cord-276456-oa6hh7ky	197	38	the	the	DT
cord-276456-oa6hh7ky	197	39	proposed	propose	VBN
cord-276456-oa6hh7ky	197	40	mechanism	mechanism	NN
cord-276456-oa6hh7ky	197	41	for	for	IN
cord-276456-oa6hh7ky	197	42	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	197	43	.	.	.
cord-276456-oa6hh7ky	198	1	29	29	CD
cord-276456-oa6hh7ky	198	2	WT	WT	NNP
cord-276456-oa6hh7ky	198	3	-	-	HYPH
cord-276456-oa6hh7ky	198	4	pH	pH	NNP
cord-276456-oa6hh7ky	198	5	7	7	CD
cord-276456-oa6hh7ky	198	6	.	.	.
cord-276456-oa6hh7ky	199	1	One	one	CD
cord-276456-oa6hh7ky	199	2	suggestion	suggestion	NN
cord-276456-oa6hh7ky	199	3	is	be	VBZ
cord-276456-oa6hh7ky	199	4	that	that	IN
cord-276456-oa6hh7ky	199	5	the	the	DT
cord-276456-oa6hh7ky	199	6	membrane	membrane	NN
cord-276456-oa6hh7ky	199	7	helices	helix	NNS
cord-276456-oa6hh7ky	199	8	of	of	IN
cord-276456-oa6hh7ky	199	9	the	the	DT
cord-276456-oa6hh7ky	199	10	fusion	fusion	NN
cord-276456-oa6hh7ky	199	11	peptide	peptide	NN
cord-276456-oa6hh7ky	199	12	and	and	CC
cord-276456-oa6hh7ky	199	13	the	the	DT
cord-276456-oa6hh7ky	199	14	TMD	TMD	NNP
cord-276456-oa6hh7ky	199	15	could	could	MD
cord-276456-oa6hh7ky	199	16	interact	interact	VB
cord-276456-oa6hh7ky	199	17	with	with	IN
cord-276456-oa6hh7ky	199	18	each	each	DT
cord-276456-oa6hh7ky	199	19	other	other	JJ
cord-276456-oa6hh7ky	199	20	,	,	,
cord-276456-oa6hh7ky	199	21	so	so	RB
cord-276456-oa6hh7ky	199	22	providing	provide	VBG
cord-276456-oa6hh7ky	199	23	a	a	DT
cord-276456-oa6hh7ky	199	24	driving	drive	VBG
cord-276456-oa6hh7ky	199	25	force	force	NN
cord-276456-oa6hh7ky	199	26	for	for	IN
cord-276456-oa6hh7ky	199	27	the	the	DT
cord-276456-oa6hh7ky	199	28	mixing	mixing	NN
cord-276456-oa6hh7ky	199	29	of	of	IN
cord-276456-oa6hh7ky	199	30	two	two	CD
cord-276456-oa6hh7ky	199	31	membranes	membrane	NNS
cord-276456-oa6hh7ky	199	32	.	.	.
cord-276456-oa6hh7ky	200	1	64	64	CD
cord-276456-oa6hh7ky	201	1	Other	other	JJ
cord-276456-oa6hh7ky	201	2	open	open	JJ
cord-276456-oa6hh7ky	201	3	questions	question	NNS
cord-276456-oa6hh7ky	201	4	include	include	VBP
cord-276456-oa6hh7ky	201	5	the	the	DT
cord-276456-oa6hh7ky	201	6	study	study	NN
cord-276456-oa6hh7ky	201	7	of	of	IN
cord-276456-oa6hh7ky	201	8	HA	HA	NNP
cord-276456-oa6hh7ky	201	9	fusion	fusion	NN
cord-276456-oa6hh7ky	201	10	(	(	-LRB-
cord-276456-oa6hh7ky	201	11	and	and	CC
cord-276456-oa6hh7ky	201	12	other	other	JJ
cord-276456-oa6hh7ky	201	13	enveloped	envelop	VBN
cord-276456-oa6hh7ky	201	14	viruses	virus	NNS
cord-276456-oa6hh7ky	201	15	)	)	-RRB-
cord-276456-oa6hh7ky	201	16	in	in	IN
cord-276456-oa6hh7ky	201	17	the	the	DT
cord-276456-oa6hh7ky	201	18	context	context	NN
cord-276456-oa6hh7ky	201	19	of	of	IN
cord-276456-oa6hh7ky	201	20	negative	negative	JJ
cord-276456-oa6hh7ky	201	21	membrane	membrane	NN
cord-276456-oa6hh7ky	201	22	curvatures	curvature	NNS
cord-276456-oa6hh7ky	201	23	found	find	VBN
cord-276456-oa6hh7ky	201	24	in	in	IN
cord-276456-oa6hh7ky	201	25	the	the	DT
cord-276456-oa6hh7ky	201	26	multi	multi	JJ
cord-276456-oa6hh7ky	201	27	-	-	JJ
cord-276456-oa6hh7ky	201	28	vesicular	vesicular	JJ
cord-276456-oa6hh7ky	201	29	bodies	body	NNS
cord-276456-oa6hh7ky	201	30	of	of	IN
cord-276456-oa6hh7ky	201	31	endosomal	endosomal	NNP
cord-276456-oa6hh7ky	201	32	compartments	compartment	NNS
cord-276456-oa6hh7ky	201	33	,	,	,
cord-276456-oa6hh7ky	201	34	65	65	CD
cord-276456-oa6hh7ky	201	35	and	and	CC
cord-276456-oa6hh7ky	201	36	lipids	lipid	NNS
cord-276456-oa6hh7ky	201	37	known	know	VBN
cord-276456-oa6hh7ky	201	38	to	to	TO
cord-276456-oa6hh7ky	201	39	be	be	VB
cord-276456-oa6hh7ky	201	40	enriched	enrich	VBN
cord-276456-oa6hh7ky	201	41	in	in	IN
cord-276456-oa6hh7ky	201	42	endosomes	endosome	NNS
cord-276456-oa6hh7ky	201	43	.	.	.
cord-276456-oa6hh7ky	202	1	Another	another	DT
cord-276456-oa6hh7ky	202	2	open	open	JJ
cord-276456-oa6hh7ky	202	3	question	question	NN
cord-276456-oa6hh7ky	202	4	is	be	VBZ
cord-276456-oa6hh7ky	202	5	whether	whether	IN
cord-276456-oa6hh7ky	202	6	the	the	DT
cord-276456-oa6hh7ky	202	7	HA	HA	NNP
cord-276456-oa6hh7ky	202	8	conformational	conformational	JJ
cord-276456-oa6hh7ky	202	9	changes	change	NNS
cord-276456-oa6hh7ky	202	10	are	be	VBP
cord-276456-oa6hh7ky	202	11	strictly	strictly	RB
cord-276456-oa6hh7ky	202	12	irreversible	irreversible	JJ
cord-276456-oa6hh7ky	202	13	in	in	IN
cord-276456-oa6hh7ky	202	14	the	the	DT
cord-276456-oa6hh7ky	202	15	absence	absence	NN
cord-276456-oa6hh7ky	202	16	of	of	IN
cord-276456-oa6hh7ky	202	17	a	a	DT
cord-276456-oa6hh7ky	202	18	target	target	NN
cord-276456-oa6hh7ky	202	19	membrane	membrane	NN
cord-276456-oa6hh7ky	202	20	.	.	.
cord-276456-oa6hh7ky	203	1	The	the	DT
cord-276456-oa6hh7ky	203	2	prevailing	prevailing	JJ
cord-276456-oa6hh7ky	203	3	model	model	NN
cord-276456-oa6hh7ky	203	4	that	that	IN
cord-276456-oa6hh7ky	203	5	spring	spring	NN
cord-276456-oa6hh7ky	203	6	-	-	HYPH
cord-276456-oa6hh7ky	203	7	loaded	load	VBN
cord-276456-oa6hh7ky	203	8	conformational	conformational	JJ
cord-276456-oa6hh7ky	203	9	changes	change	NNS
cord-276456-oa6hh7ky	203	10	are	be	VBP
cord-276456-oa6hh7ky	203	11	uni	uni	JJ
cord-276456-oa6hh7ky	203	12	-	-	HYPH
cord-276456-oa6hh7ky	203	13	directional	directional	JJ
cord-276456-oa6hh7ky	203	14	is	be	VBZ
cord-276456-oa6hh7ky	203	15	based	base	VBN
cord-276456-oa6hh7ky	203	16	in	in	IN
cord-276456-oa6hh7ky	203	17	part	part	NN
cord-276456-oa6hh7ky	203	18	on	on	IN
cord-276456-oa6hh7ky	203	19	the	the	DT
cord-276456-oa6hh7ky	203	20	fact	fact	NN
cord-276456-oa6hh7ky	203	21	that	that	IN
cord-276456-oa6hh7ky	203	22	pre	pre	JJ
cord-276456-oa6hh7ky	203	23	-	-	NN
cord-276456-oa6hh7ky	203	24	treatment	treatment	NN
cord-276456-oa6hh7ky	203	25	of	of	IN
cord-276456-oa6hh7ky	203	26	virus	virus	NN
cord-276456-oa6hh7ky	203	27	particles	particle	NNS
cord-276456-oa6hh7ky	203	28	from	from	IN
cord-276456-oa6hh7ky	203	29	typical	typical	JJ
cord-276456-oa6hh7ky	203	30	laboratory	laboratory	NN
cord-276456-oa6hh7ky	203	31	strains	strain	NNS
cord-276456-oa6hh7ky	203	32	(	(	-LRB-
cord-276456-oa6hh7ky	203	33	e.g.	e.g.	RB
cord-276456-oa6hh7ky	203	34	,	,	,
cord-276456-oa6hh7ky	203	35	the	the	DT
cord-276456-oa6hh7ky	203	36	H3	H3	NNP
cord-276456-oa6hh7ky	203	37	strain	strain	NN
cord-276456-oa6hh7ky	203	38	X-31	X-31	NNP
cord-276456-oa6hh7ky	203	39	)	)	-RRB-
cord-276456-oa6hh7ky	203	40	with	with	IN
cord-276456-oa6hh7ky	203	41	low	low	JJ
cord-276456-oa6hh7ky	203	42	pH	pH	NNP
cord-276456-oa6hh7ky	203	43	effectively	effectively	RB
cord-276456-oa6hh7ky	203	44	neutralizes	neutralize	VBZ
cord-276456-oa6hh7ky	203	45	infection	infection	NN
cord-276456-oa6hh7ky	203	46	.	.	.
cord-276456-oa6hh7ky	204	1	Analysis	analysis	NN
cord-276456-oa6hh7ky	204	2	of	of	IN
cord-276456-oa6hh7ky	204	3	other	other	JJ
cord-276456-oa6hh7ky	204	4	viral	viral	JJ
cord-276456-oa6hh7ky	204	5	subtypes	subtype	NNS
cord-276456-oa6hh7ky	205	1	(	(	-LRB-
cord-276456-oa6hh7ky	205	2	e.g.	e.g.	RB
cord-276456-oa6hh7ky	205	3	,	,	,
cord-276456-oa6hh7ky	205	4	H2	H2	NNP
cord-276456-oa6hh7ky	205	5	)	)	-RRB-
cord-276456-oa6hh7ky	205	6	show	show	NN
cord-276456-oa6hh7ky	205	7	features	feature	VBZ
cord-276456-oa6hh7ky	205	8	consistent	consistent	JJ
cord-276456-oa6hh7ky	205	9	with	with	IN
cord-276456-oa6hh7ky	205	10	reversible	reversible	JJ
cord-276456-oa6hh7ky	205	11	conformational	conformational	JJ
cord-276456-oa6hh7ky	205	12	changes	change	NNS
cord-276456-oa6hh7ky	205	13	66	66	CD
cord-276456-oa6hh7ky	205	14	and	and	CC
cord-276456-oa6hh7ky	206	1	many	many	JJ
cord-276456-oa6hh7ky	206	2	natural	natural	JJ
cord-276456-oa6hh7ky	206	3	isolates	isolate	NNS
cord-276456-oa6hh7ky	206	4	of	of	IN
cord-276456-oa6hh7ky	206	5	influenza	influenza	NN
cord-276456-oa6hh7ky	206	6	do	do	VBP
cord-276456-oa6hh7ky	206	7	not	not	RB
cord-276456-oa6hh7ky	206	8	show	show	VB
cord-276456-oa6hh7ky	206	9	the	the	DT
cord-276456-oa6hh7ky	206	10	irreversible	irreversible	JJ
cord-276456-oa6hh7ky	206	11	conformational	conformational	JJ
cord-276456-oa6hh7ky	206	12	changes	change	NNS
cord-276456-oa6hh7ky	206	13	associated	associate	VBN
cord-276456-oa6hh7ky	206	14	with	with	IN
cord-276456-oa6hh7ky	206	15	X-31	X-31	NNP
cord-276456-oa6hh7ky	206	16	in	in	IN
cord-276456-oa6hh7ky	206	17	the	the	DT
cord-276456-oa6hh7ky	206	18	absence	absence	NN
cord-276456-oa6hh7ky	206	19	of	of	IN
cord-276456-oa6hh7ky	206	20	a	a	DT
cord-276456-oa6hh7ky	206	21	target	target	NN
cord-276456-oa6hh7ky	206	22	membrane	membrane	NN
cord-276456-oa6hh7ky	206	23	(	(	-LRB-
cord-276456-oa6hh7ky	206	24	G.	G.	NNP
cord-276456-oa6hh7ky	206	25	Whittaker	Whittaker	NNP
cord-276456-oa6hh7ky	206	26	personal	personal	JJ
cord-276456-oa6hh7ky	206	27	communication	communication	NN
cord-276456-oa6hh7ky	206	28	)	)	-RRB-
cord-276456-oa6hh7ky	206	29	.	.	.
cord-276456-oa6hh7ky	207	1	Tatulian	Tatulian	NNP
cord-276456-oa6hh7ky	207	2	and	and	CC
cord-276456-oa6hh7ky	207	3	Tamm	Tamm	NNP
cord-276456-oa6hh7ky	207	4	67	67	CD
cord-276456-oa6hh7ky	207	5	have	have	VBP
cord-276456-oa6hh7ky	207	6	demonstrated	demonstrate	VBN
cord-276456-oa6hh7ky	207	7	that	that	IN
cord-276456-oa6hh7ky	207	8	the	the	DT
cord-276456-oa6hh7ky	207	9	conformational	conformational	JJ
cord-276456-oa6hh7ky	207	10	change	change	NN
cord-276456-oa6hh7ky	207	11	of	of	IN
cord-276456-oa6hh7ky	207	12	the	the	DT
cord-276456-oa6hh7ky	207	13	entire	entire	JJ
cord-276456-oa6hh7ky	207	14	HA	HA	NNP
cord-276456-oa6hh7ky	207	15	is	be	VBZ
cord-276456-oa6hh7ky	207	16	reversible	reversible	JJ
cord-276456-oa6hh7ky	207	17	in	in	IN
cord-276456-oa6hh7ky	207	18	the	the	DT
cord-276456-oa6hh7ky	207	19	absence	absence	NN
cord-276456-oa6hh7ky	207	20	of	of	IN
cord-276456-oa6hh7ky	207	21	bound	bind	VBN
cord-276456-oa6hh7ky	207	22	target	target	NN
cord-276456-oa6hh7ky	207	23	membranes	membrane	NNS
cord-276456-oa6hh7ky	207	24	.	.	.
cord-276456-oa6hh7ky	208	1	The	the	DT
cord-276456-oa6hh7ky	208	2	formation	formation	NN
cord-276456-oa6hh7ky	208	3	of	of	IN
cord-276456-oa6hh7ky	208	4	a	a	DT
cord-276456-oa6hh7ky	208	5	six	six	CD
cord-276456-oa6hh7ky	208	6	-	-	HYPH
cord-276456-oa6hh7ky	208	7	helix	helix	NN
cord-276456-oa6hh7ky	208	8	bundle	bundle	NN
cord-276456-oa6hh7ky	208	9	(	(	-LRB-
cord-276456-oa6hh7ky	208	10	6HB	6HB	NNP
cord-276456-oa6hh7ky	208	11	)	)	-RRB-
cord-276456-oa6hh7ky	208	12	is	be	VBZ
cord-276456-oa6hh7ky	208	13	the	the	DT
cord-276456-oa6hh7ky	208	14	structural	structural	JJ
cord-276456-oa6hh7ky	208	15	feature	feature	NN
cord-276456-oa6hh7ky	208	16	that	that	WDT
cord-276456-oa6hh7ky	208	17	characterizes	characterize	VBZ
cord-276456-oa6hh7ky	208	18	class	class	NN
cord-276456-oa6hh7ky	208	19	I	-PRON-	PRP
cord-276456-oa6hh7ky	208	20	viral	viral	JJ
cord-276456-oa6hh7ky	208	21	fusion	fusion	NN
cord-276456-oa6hh7ky	208	22	proteins	protein	NNS
cord-276456-oa6hh7ky	208	23	.	.	.
cord-276456-oa6hh7ky	209	1	Because	because	IN
cord-276456-oa6hh7ky	209	2	fusion	fusion	NN
cord-276456-oa6hh7ky	209	3	peptides	peptide	NNS
cord-276456-oa6hh7ky	209	4	insert	insert	VBP
cord-276456-oa6hh7ky	209	5	into	into	IN
cord-276456-oa6hh7ky	209	6	target	target	NN
cord-276456-oa6hh7ky	209	7	membranes	membrane	NNS
cord-276456-oa6hh7ky	209	8	and	and	CC
cord-276456-oa6hh7ky	209	9	TMDs	tmd	NNS
cord-276456-oa6hh7ky	209	10	span	span	VBP
cord-276456-oa6hh7ky	209	11	the	the	DT
cord-276456-oa6hh7ky	209	12	viral	viral	JJ
cord-276456-oa6hh7ky	209	13	envelope	envelope	NN
cord-276456-oa6hh7ky	209	14	,	,	,
cord-276456-oa6hh7ky	209	15	the	the	DT
cord-276456-oa6hh7ky	209	16	folding	folding	NN
cord-276456-oa6hh7ky	209	17	of	of	IN
cord-276456-oa6hh7ky	209	18	fusion	fusion	NN
cord-276456-oa6hh7ky	209	19	proteins	protein	NNS
cord-276456-oa6hh7ky	209	20	into	into	IN
cord-276456-oa6hh7ky	209	21	hairpins	hairpin	NNS
cord-276456-oa6hh7ky	209	22	brings	bring	VBZ
cord-276456-oa6hh7ky	209	23	the	the	DT
cord-276456-oa6hh7ky	209	24	viral	viral	JJ
cord-276456-oa6hh7ky	209	25	envelope	envelope	NN
cord-276456-oa6hh7ky	209	26	and	and	CC
cord-276456-oa6hh7ky	209	27	host	host	NN
cord-276456-oa6hh7ky	209	28	cell	cell	NN
cord-276456-oa6hh7ky	209	29	membrane	membrane	NN
cord-276456-oa6hh7ky	209	30	into	into	IN
cord-276456-oa6hh7ky	209	31	proximity	proximity	NN
cord-276456-oa6hh7ky	209	32	.	.	.
cord-276456-oa6hh7ky	210	1	Even	even	RB
cord-276456-oa6hh7ky	210	2	for	for	IN
cord-276456-oa6hh7ky	210	3	the	the	DT
cord-276456-oa6hh7ky	210	4	two	two	CD
cord-276456-oa6hh7ky	210	5	other	other	JJ
cord-276456-oa6hh7ky	210	6	classes	class	NNS
cord-276456-oa6hh7ky	210	7	of	of	IN
cord-276456-oa6hh7ky	210	8	viral	viral	JJ
cord-276456-oa6hh7ky	210	9	fusion	fusion	NN
cord-276456-oa6hh7ky	210	10	proteins	protein	NNS
cord-276456-oa6hh7ky	210	11	,	,	,
cord-276456-oa6hh7ky	210	12	which	which	WDT
cord-276456-oa6hh7ky	210	13	do	do	VBP
cord-276456-oa6hh7ky	210	14	not	not	RB
cord-276456-oa6hh7ky	210	15	exhibit	exhibit	VB
cord-276456-oa6hh7ky	210	16	6HBs	6hbs	CD
cord-276456-oa6hh7ky	210	17	and	and	CC
cord-276456-oa6hh7ky	210	18	contain	contain	VB
cord-276456-oa6hh7ky	210	19	much	much	JJ
cord-276456-oa6hh7ky	210	20	b	b	NN
cord-276456-oa6hh7ky	210	21	-	-	HYPH
cord-276456-oa6hh7ky	210	22	sheet	sheet	NN
cord-276456-oa6hh7ky	210	23	,	,	,
cord-276456-oa6hh7ky	210	24	in	in	IN
cord-276456-oa6hh7ky	210	25	the	the	DT
cord-276456-oa6hh7ky	210	26	final	final	JJ
cord-276456-oa6hh7ky	210	27	,	,	,
cord-276456-oa6hh7ky	210	28	post	post	JJ
cord-276456-oa6hh7ky	210	29	-	-	JJ
cord-276456-oa6hh7ky	210	30	fusion	fusion	JJ
cord-276456-oa6hh7ky	210	31	state	state	NN
cord-276456-oa6hh7ky	210	32	,	,	,
cord-276456-oa6hh7ky	210	33	it	-PRON-	PRP
cord-276456-oa6hh7ky	210	34	is	be	VBZ
cord-276456-oa6hh7ky	210	35	likely	likely	JJ
cord-276456-oa6hh7ky	210	36	that	that	IN
cord-276456-oa6hh7ky	210	37	fusion	fusion	NN
cord-276456-oa6hh7ky	210	38	peptides	peptide	NNS
cord-276456-oa6hh7ky	210	39	and	and	CC
cord-276456-oa6hh7ky	210	40	TMDs	tmd	NNS
cord-276456-oa6hh7ky	210	41	are	be	VBP
cord-276456-oa6hh7ky	210	42	proximal	proximal	JJ
cord-276456-oa6hh7ky	210	43	.	.	.
cord-276456-oa6hh7ky	211	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	211	2	is	be	VBZ
cord-276456-oa6hh7ky	211	3	not	not	RB
cord-276456-oa6hh7ky	211	4	experimentally	experimentally	RB
cord-276456-oa6hh7ky	211	5	certain	certain	JJ
cord-276456-oa6hh7ky	211	6	that	that	IN
cord-276456-oa6hh7ky	211	7	this	this	DT
cord-276456-oa6hh7ky	211	8	proximity	proximity	NN
cord-276456-oa6hh7ky	211	9	occurs	occur	VBZ
cord-276456-oa6hh7ky	211	10	,	,	,
cord-276456-oa6hh7ky	211	11	because	because	IN
cord-276456-oa6hh7ky	211	12	the	the	DT
cord-276456-oa6hh7ky	211	13	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	211	14	TMDs	tmd	NNS
cord-276456-oa6hh7ky	211	15	and	and	CC
cord-276456-oa6hh7ky	211	16	fusion	fusion	NN
cord-276456-oa6hh7ky	211	17	peptides	peptide	NNS
cord-276456-oa6hh7ky	211	18	themselves	-PRON-	PRP
cord-276456-oa6hh7ky	211	19	are	be	VBP
cord-276456-oa6hh7ky	211	20	not	not	RB
cord-276456-oa6hh7ky	211	21	present	present	JJ
cord-276456-oa6hh7ky	211	22	in	in	IN
cord-276456-oa6hh7ky	211	23	the	the	DT
cord-276456-oa6hh7ky	211	24	crystallized	crystallize	VBN
cord-276456-oa6hh7ky	211	25	proteins	protein	NNS
cord-276456-oa6hh7ky	211	26	.	.	.
cord-276456-oa6hh7ky	212	1	This	this	DT
cord-276456-oa6hh7ky	212	2	apposition	apposition	NN
cord-276456-oa6hh7ky	212	3	of	of	IN
cord-276456-oa6hh7ky	212	4	the	the	DT
cord-276456-oa6hh7ky	212	5	membrane	membrane	NN
cord-276456-oa6hh7ky	212	6	imbedded	imbed	VBN
cord-276456-oa6hh7ky	212	7	TMD	TMD	NNP
cord-276456-oa6hh7ky	212	8	and	and	CC
cord-276456-oa6hh7ky	212	9	fusion	fusion	NN
cord-276456-oa6hh7ky	212	10	peptides	peptide	NNS
cord-276456-oa6hh7ky	212	11	of	of	IN
cord-276456-oa6hh7ky	212	12	viral	viral	JJ
cord-276456-oa6hh7ky	212	13	fusion	fusion	NN
cord-276456-oa6hh7ky	212	14	proteins	protein	NNS
cord-276456-oa6hh7ky	212	15	is	be	VBZ
cord-276456-oa6hh7ky	212	16	similar	similar	JJ
cord-276456-oa6hh7ky	212	17	to	to	IN
cord-276456-oa6hh7ky	212	18	the	the	DT
cord-276456-oa6hh7ky	212	19	proximity	proximity	NN
cord-276456-oa6hh7ky	212	20	between	between	IN
cord-276456-oa6hh7ky	212	21	TMDs	tmd	NNS
cord-276456-oa6hh7ky	212	22	of	of	IN
cord-276456-oa6hh7ky	212	23	v	v	NN
cord-276456-oa6hh7ky	212	24	-	-	:
cord-276456-oa6hh7ky	212	25	and	and	CC
cord-276456-oa6hh7ky	212	26	t	t	NNP
cord-276456-oa6hh7ky	212	27	-	-	HYPH
cord-276456-oa6hh7ky	212	28	SNAREs	SNAREs	NNP
cord-276456-oa6hh7ky	212	29	in	in	IN
cord-276456-oa6hh7ky	212	30	their	-PRON-	PRP$
cord-276456-oa6hh7ky	212	31	tetrameric	tetrameric	JJ
cord-276456-oa6hh7ky	212	32	coiledcoil	coiledcoil	NN
cord-276456-oa6hh7ky	212	33	.	.	.
cord-276456-oa6hh7ky	213	1	When	when	WRB
cord-276456-oa6hh7ky	213	2	the	the	DT
cord-276456-oa6hh7ky	213	3	ubiquity	ubiquity	NN
cord-276456-oa6hh7ky	213	4	of	of	IN
cord-276456-oa6hh7ky	213	5	6HBs	6hbs	CD
cord-276456-oa6hh7ky	213	6	was	be	VBD
cord-276456-oa6hh7ky	213	7	first	first	RB
cord-276456-oa6hh7ky	213	8	demonstrated	demonstrate	VBN
cord-276456-oa6hh7ky	213	9	,	,	,
cord-276456-oa6hh7ky	213	10	it	-PRON-	PRP
cord-276456-oa6hh7ky	213	11	was	be	VBD
cord-276456-oa6hh7ky	213	12	assumed	assume	VBN
cord-276456-oa6hh7ky	213	13	that	that	DT
cord-276456-oa6hh7ky	213	14	bundle	bundle	NN
cord-276456-oa6hh7ky	213	15	formation	formation	NN
cord-276456-oa6hh7ky	213	16	merely	merely	RB
cord-276456-oa6hh7ky	213	17	brought	bring	VBD
cord-276456-oa6hh7ky	213	18	membranes	membrane	NNS
cord-276456-oa6hh7ky	213	19	into	into	IN
cord-276456-oa6hh7ky	213	20	close	close	JJ
cord-276456-oa6hh7ky	213	21	contact	contact	NN
cord-276456-oa6hh7ky	213	22	,	,	,
cord-276456-oa6hh7ky	213	23	and	and	CC
cord-276456-oa6hh7ky	213	24	fusion	fusion	NN
cord-276456-oa6hh7ky	213	25	then	then	RB
cord-276456-oa6hh7ky	213	26	occurred	occur	VBD
cord-276456-oa6hh7ky	213	27	.	.	.
cord-276456-oa6hh7ky	214	1	We	-PRON-	PRP
cord-276456-oa6hh7ky	214	2	now	now	RB
cord-276456-oa6hh7ky	214	3	know	know	VBP
cord-276456-oa6hh7ky	214	4	this	this	DT
cord-276456-oa6hh7ky	214	5	is	be	VBZ
cord-276456-oa6hh7ky	214	6	incorrect	incorrect	JJ
cord-276456-oa6hh7ky	214	7	.	.	.
cord-276456-oa6hh7ky	215	1	The	the	DT
cord-276456-oa6hh7ky	215	2	correlations	correlation	NNS
cord-276456-oa6hh7ky	215	3	between	between	IN
cord-276456-oa6hh7ky	215	4	bundle	bundle	NN
cord-276456-oa6hh7ky	215	5	formation	formation	NN
cord-276456-oa6hh7ky	215	6	and	and	CC
cord-276456-oa6hh7ky	215	7	steps	step	NNS
cord-276456-oa6hh7ky	215	8	in	in	IN
cord-276456-oa6hh7ky	215	9	the	the	DT
cord-276456-oa6hh7ky	215	10	fusion	fusion	NN
cord-276456-oa6hh7ky	215	11	process	process	NN
cord-276456-oa6hh7ky	215	12	have	have	VBP
cord-276456-oa6hh7ky	215	13	been	be	VBN
cord-276456-oa6hh7ky	215	14	investigated	investigate	VBN
cord-276456-oa6hh7ky	215	15	for	for	IN
cord-276456-oa6hh7ky	215	16	HIV-1	HIV-1	NNP
cord-276456-oa6hh7ky	215	17	Env	Env	NNP
cord-276456-oa6hh7ky	215	18	,	,	,
cord-276456-oa6hh7ky	215	19	Influenza	Influenza	NNP
cord-276456-oa6hh7ky	215	20	HA	HA	NNP
cord-276456-oa6hh7ky	215	21	,	,	,
cord-276456-oa6hh7ky	215	22	and	and	CC
cord-276456-oa6hh7ky	215	23	ASLV	ASLV	NNP
cord-276456-oa6hh7ky	215	24	Env	Env	NNP
cord-276456-oa6hh7ky	215	25	.	.	.
cord-276456-oa6hh7ky	216	1	The	the	DT
cord-276456-oa6hh7ky	216	2	precise	precise	JJ
cord-276456-oa6hh7ky	216	3	steps	step	NNS
cord-276456-oa6hh7ky	216	4	of	of	IN
cord-276456-oa6hh7ky	216	5	bundle	bundle	NN
cord-276456-oa6hh7ky	216	6	formation	formation	NN
cord-276456-oa6hh7ky	216	7	depend	depend	VBP
cord-276456-oa6hh7ky	216	8	on	on	IN
cord-276456-oa6hh7ky	216	9	the	the	DT
cord-276456-oa6hh7ky	216	10	precise	precise	JJ
cord-276456-oa6hh7ky	216	11	protein	protein	NN
cord-276456-oa6hh7ky	216	12	.	.	.
cord-276456-oa6hh7ky	217	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	217	2	appears	appear	VBZ
cord-276456-oa6hh7ky	217	3	that	that	IN
cord-276456-oa6hh7ky	217	4	the	the	DT
cord-276456-oa6hh7ky	217	5	longer	long	RBR
cord-276456-oa6hh7ky	217	6	the	the	DT
cord-276456-oa6hh7ky	217	7	amino	amino	NN
cord-276456-oa6hh7ky	217	8	acid	acid	NN
cord-276456-oa6hh7ky	217	9	sequence	sequence	NN
cord-276456-oa6hh7ky	217	10	that	that	WDT
cord-276456-oa6hh7ky	217	11	intervenes	intervene	VBZ
cord-276456-oa6hh7ky	217	12	between	between	IN
cord-276456-oa6hh7ky	217	13	TMDs	tmd	NNS
cord-276456-oa6hh7ky	217	14	and	and	CC
cord-276456-oa6hh7ky	217	15	the	the	DT
cord-276456-oa6hh7ky	217	16	coiled	coil	VBN
cord-276456-oa6hh7ky	217	17	-	-	HYPH
cord-276456-oa6hh7ky	217	18	coil	coil	NN
cord-276456-oa6hh7ky	217	19	,	,	,
cord-276456-oa6hh7ky	217	20	the	the	DT
cord-276456-oa6hh7ky	217	21	earlier	early	JJR
cord-276456-oa6hh7ky	217	22	the	the	DT
cord-276456-oa6hh7ky	217	23	bundle	bundle	NN
cord-276456-oa6hh7ky	217	24	can	can	MD
cord-276456-oa6hh7ky	217	25	form	form	VB
cord-276456-oa6hh7ky	217	26	.	.	.
cord-276456-oa6hh7ky	218	1	For	for	IN
cord-276456-oa6hh7ky	218	2	HIV-1	HIV-1	NNP
cord-276456-oa6hh7ky	218	3	Env	Env	NNP
cord-276456-oa6hh7ky	218	4	,	,	,
cord-276456-oa6hh7ky	218	5	which	which	WDT
cord-276456-oa6hh7ky	218	6	has	have	VBZ
cord-276456-oa6hh7ky	218	7	a	a	DT
cord-276456-oa6hh7ky	218	8	relatively	relatively	RB
cord-276456-oa6hh7ky	218	9	short	short	JJ
cord-276456-oa6hh7ky	218	10	intervening	intervene	VBG
cord-276456-oa6hh7ky	218	11	sequence	sequence	NN
cord-276456-oa6hh7ky	218	12	,	,	,
cord-276456-oa6hh7ky	218	13	not	not	RB
cord-276456-oa6hh7ky	218	14	only	only	RB
cord-276456-oa6hh7ky	218	15	does	do	VBZ
cord-276456-oa6hh7ky	218	16	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	218	17	occur	occur	VB
cord-276456-oa6hh7ky	218	18	prior	prior	RB
cord-276456-oa6hh7ky	218	19	to	to	IN
cord-276456-oa6hh7ky	218	20	completion	completion	NN
cord-276456-oa6hh7ky	218	21	of	of	IN
cord-276456-oa6hh7ky	218	22	bundle	bundle	NN
cord-276456-oa6hh7ky	218	23	formation	formation	NN
cord-276456-oa6hh7ky	218	24	,	,	,
cord-276456-oa6hh7ky	218	25	but	but	CC
cord-276456-oa6hh7ky	218	26	so	so	RB
cord-276456-oa6hh7ky	218	27	does	do	VBZ
cord-276456-oa6hh7ky	218	28	the	the	DT
cord-276456-oa6hh7ky	218	29	creation	creation	NN
cord-276456-oa6hh7ky	218	30	of	of	IN
cord-276456-oa6hh7ky	218	31	the	the	DT
cord-276456-oa6hh7ky	218	32	initial	initial	JJ
cord-276456-oa6hh7ky	218	33	fusion	fusion	NN
cord-276456-oa6hh7ky	218	34	pore	pore	NN
cord-276456-oa6hh7ky	218	35	.	.	.
cord-276456-oa6hh7ky	219	1	Bundle	bundle	NN
cord-276456-oa6hh7ky	219	2	formation	formation	NN
cord-276456-oa6hh7ky	219	3	releases	release	VBZ
cord-276456-oa6hh7ky	219	4	considerable	considerable	JJ
cord-276456-oa6hh7ky	219	5	energy	energy	NN
cord-276456-oa6hh7ky	219	6	and	and	CC
cord-276456-oa6hh7ky	219	7	the	the	DT
cord-276456-oa6hh7ky	219	8	late	late	JJ
cord-276456-oa6hh7ky	219	9	occurrence	occurrence	NN
cord-276456-oa6hh7ky	219	10	of	of	IN
cord-276456-oa6hh7ky	219	11	formation	formation	NN
cord-276456-oa6hh7ky	219	12	indicates	indicate	VBZ
cord-276456-oa6hh7ky	219	13	that	that	IN
cord-276456-oa6hh7ky	219	14	considerable	considerable	JJ
cord-276456-oa6hh7ky	219	15	energy	energy	NN
cord-276456-oa6hh7ky	219	16	is	be	VBZ
cord-276456-oa6hh7ky	219	17	required	require	VBN
cord-276456-oa6hh7ky	219	18	for	for	IN
cord-276456-oa6hh7ky	219	19	pore	pore	NN
cord-276456-oa6hh7ky	219	20	enlargement	enlargement	NN
cord-276456-oa6hh7ky	219	21	-the	-the	DT
cord-276456-oa6hh7ky	219	22	last	last	JJ
cord-276456-oa6hh7ky	219	23	step	step	NN
cord-276456-oa6hh7ky	219	24	in	in	IN
cord-276456-oa6hh7ky	219	25	fusion	fusion	NN
cord-276456-oa6hh7ky	219	26	.	.	.
cord-276456-oa6hh7ky	220	1	In	in	IN
cord-276456-oa6hh7ky	220	2	fact	fact	NN
cord-276456-oa6hh7ky	220	3	,	,	,
cord-276456-oa6hh7ky	220	4	several	several	JJ
cord-276456-oa6hh7ky	220	5	lines	line	NNS
cord-276456-oa6hh7ky	220	6	of	of	IN
cord-276456-oa6hh7ky	220	7	evidence	evidence	NN
cord-276456-oa6hh7ky	220	8	lead	lead	NN
cord-276456-oa6hh7ky	220	9	to	to	IN
cord-276456-oa6hh7ky	220	10	the	the	DT
cord-276456-oa6hh7ky	220	11	picture	picture	NN
cord-276456-oa6hh7ky	220	12	that	that	WDT
cord-276456-oa6hh7ky	220	13	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	220	14	is	be	VBZ
cord-276456-oa6hh7ky	220	15	energetically	energetically	RB
cord-276456-oa6hh7ky	220	16	easy	easy	JJ
cord-276456-oa6hh7ky	220	17	to	to	TO
cord-276456-oa6hh7ky	220	18	achieve	achieve	VB
cord-276456-oa6hh7ky	220	19	,	,	,
cord-276456-oa6hh7ky	220	20	pore	pore	NN
cord-276456-oa6hh7ky	220	21	formation	formation	NN
cord-276456-oa6hh7ky	220	22	more	more	RBR
cord-276456-oa6hh7ky	220	23	difficult	difficult	JJ
cord-276456-oa6hh7ky	220	24	,	,	,
cord-276456-oa6hh7ky	220	25	and	and	CC
cord-276456-oa6hh7ky	220	26	pore	pore	NN
cord-276456-oa6hh7ky	220	27	enlargement	enlargement	NN
cord-276456-oa6hh7ky	220	28	even	even	RB
cord-276456-oa6hh7ky	220	29	more	more	RBR
cord-276456-oa6hh7ky	220	30	difficult	difficult	JJ
cord-276456-oa6hh7ky	220	31	.	.	.
cord-276456-oa6hh7ky	221	1	From	from	IN
cord-276456-oa6hh7ky	221	2	the	the	DT
cord-276456-oa6hh7ky	221	3	theoretical	theoretical	JJ
cord-276456-oa6hh7ky	221	4	point	point	NN
cord-276456-oa6hh7ky	221	5	of	of	IN
cord-276456-oa6hh7ky	221	6	view	view	NN
cord-276456-oa6hh7ky	221	7	of	of	IN
cord-276456-oa6hh7ky	221	8	membrane	membrane	NN
cord-276456-oa6hh7ky	221	9	mechanics	mechanic	NNS
cord-276456-oa6hh7ky	221	10	,	,	,
cord-276456-oa6hh7ky	221	11	considerable	considerable	JJ
cord-276456-oa6hh7ky	221	12	work	work	NN
cord-276456-oa6hh7ky	221	13	must	must	MD
cord-276456-oa6hh7ky	221	14	be	be	VB
cord-276456-oa6hh7ky	221	15	expended	expend	VBN
cord-276456-oa6hh7ky	221	16	to	to	TO
cord-276456-oa6hh7ky	221	17	enlarge	enlarge	VB
cord-276456-oa6hh7ky	221	18	a	a	DT
cord-276456-oa6hh7ky	221	19	fusion	fusion	NN
cord-276456-oa6hh7ky	221	20	pore	pore	NN
cord-276456-oa6hh7ky	221	21	because	because	IN
cord-276456-oa6hh7ky	221	22	additional	additional	JJ
cord-276456-oa6hh7ky	221	23	membrane	membrane	NN
cord-276456-oa6hh7ky	221	24	must	must	MD
cord-276456-oa6hh7ky	221	25	be	be	VB
cord-276456-oa6hh7ky	221	26	bent	bend	VBN
cord-276456-oa6hh7ky	221	27	from	from	IN
cord-276456-oa6hh7ky	221	28	its	-PRON-	PRP$
cord-276456-oa6hh7ky	221	29	relaxed	relaxed	JJ
cord-276456-oa6hh7ky	221	30	state	state	NN
cord-276456-oa6hh7ky	221	31	as	as	IN
cord-276456-oa6hh7ky	221	32	the	the	DT
cord-276456-oa6hh7ky	221	33	pore	pore	NN
cord-276456-oa6hh7ky	221	34	enlarges	enlarge	VBZ
cord-276456-oa6hh7ky	221	35	.	.	.
cord-276456-oa6hh7ky	222	1	The	the	DT
cord-276456-oa6hh7ky	222	2	requirements	requirement	NNS
cord-276456-oa6hh7ky	222	3	for	for	IN
cord-276456-oa6hh7ky	222	4	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	222	5	are	be	VBP
cord-276456-oa6hh7ky	222	6	reasonably	reasonably	RB
cord-276456-oa6hh7ky	222	7	well	well	RB
cord-276456-oa6hh7ky	222	8	understood	understand	VBN
cord-276456-oa6hh7ky	222	9	:	:	:
cord-276456-oa6hh7ky	222	10	the	the	DT
cord-276456-oa6hh7ky	222	11	standard	standard	JJ
cord-276456-oa6hh7ky	222	12	Helfrich	Helfrich	NNP
cord-276456-oa6hh7ky	222	13	concepts	concept	NNS
cord-276456-oa6hh7ky	222	14	of	of	IN
cord-276456-oa6hh7ky	222	15	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	222	16	membrane	membrane	NN
cord-276456-oa6hh7ky	222	17	curvature	curvature	NN
cord-276456-oa6hh7ky	222	18	and	and	CC
cord-276456-oa6hh7ky	222	19	bending	bend	VBG
cord-276456-oa6hh7ky	222	20	energy	energy	NN
cord-276456-oa6hh7ky	222	21	are	be	VBP
cord-276456-oa6hh7ky	222	22	sufficient	sufficient	JJ
cord-276456-oa6hh7ky	222	23	to	to	TO
cord-276456-oa6hh7ky	222	24	account	account	VB
cord-276456-oa6hh7ky	222	25	for	for	IN
cord-276456-oa6hh7ky	222	26	experimental	experimental	JJ
cord-276456-oa6hh7ky	222	27	observation	observation	NN
cord-276456-oa6hh7ky	222	28	.	.	.
cord-276456-oa6hh7ky	223	1	The	the	DT
cord-276456-oa6hh7ky	223	2	mechanisms	mechanism	NNS
cord-276456-oa6hh7ky	223	3	by	by	IN
cord-276456-oa6hh7ky	223	4	which	which	WDT
cord-276456-oa6hh7ky	223	5	fusion	fusion	NN
cord-276456-oa6hh7ky	223	6	proteins	protein	NNS
cord-276456-oa6hh7ky	223	7	create	create	VBP
cord-276456-oa6hh7ky	223	8	the	the	DT
cord-276456-oa6hh7ky	223	9	pore	pore	NN
cord-276456-oa6hh7ky	223	10	formation	formation	NN
cord-276456-oa6hh7ky	223	11	is	be	VBZ
cord-276456-oa6hh7ky	223	12	less	less	RBR
cord-276456-oa6hh7ky	223	13	understood	understand	VBN
cord-276456-oa6hh7ky	223	14	and	and	CC
cord-276456-oa6hh7ky	223	15	how	how	WRB
cord-276456-oa6hh7ky	223	16	fusion	fusion	NN
cord-276456-oa6hh7ky	223	17	proteins	protein	NNS
cord-276456-oa6hh7ky	223	18	contribute	contribute	VBP
cord-276456-oa6hh7ky	223	19	to	to	TO
cord-276456-oa6hh7ky	223	20	pore	pore	NN
cord-276456-oa6hh7ky	223	21	enlargement	enlargement	NN
cord-276456-oa6hh7ky	223	22	remains	remain	VBZ
cord-276456-oa6hh7ky	223	23	a	a	DT
cord-276456-oa6hh7ky	223	24	mystery	mystery	NN
cord-276456-oa6hh7ky	223	25	.	.	.
cord-276456-oa6hh7ky	224	1	For	for	IN
cord-276456-oa6hh7ky	224	2	topological	topological	JJ
cord-276456-oa6hh7ky	224	3	reasons	reason	NNS
cord-276456-oa6hh7ky	224	4	,	,	,
cord-276456-oa6hh7ky	224	5	TMDs	tmd	NNS
cord-276456-oa6hh7ky	224	6	can	can	MD
cord-276456-oa6hh7ky	224	7	not	not	RB
cord-276456-oa6hh7ky	224	8	span	span	VB
cord-276456-oa6hh7ky	224	9	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	224	10	diaphragms	diaphragm	NNS
cord-276456-oa6hh7ky	224	11	and	and	CC
cord-276456-oa6hh7ky	224	12	can	can	MD
cord-276456-oa6hh7ky	224	13	only	only	RB
cord-276456-oa6hh7ky	224	14	enter	enter	VB
cord-276456-oa6hh7ky	224	15	the	the	DT
cord-276456-oa6hh7ky	224	16	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	224	17	from	from	IN
cord-276456-oa6hh7ky	224	18	the	the	DT
cord-276456-oa6hh7ky	224	19	junction	junction	NN
cord-276456-oa6hh7ky	224	20	between	between	IN
cord-276456-oa6hh7ky	224	21	the	the	DT
cord-276456-oa6hh7ky	224	22	diaphragm	diaphragm	NN
cord-276456-oa6hh7ky	224	23	and	and	CC
cord-276456-oa6hh7ky	224	24	the	the	DT
cord-276456-oa6hh7ky	224	25	two	two	CD
cord-276456-oa6hh7ky	224	26	original	original	JJ
cord-276456-oa6hh7ky	224	27	membranes	membrane	NNS
cord-276456-oa6hh7ky	224	28	.	.	.
cord-276456-oa6hh7ky	225	1	Common	common	JJ
cord-276456-oa6hh7ky	225	2	sense	sense	NN
cord-276456-oa6hh7ky	225	3	suggests	suggest	VBZ
cord-276456-oa6hh7ky	225	4	that	that	IN
cord-276456-oa6hh7ky	225	5	this	this	DT
cord-276456-oa6hh7ky	225	6	entry	entry	NN
cord-276456-oa6hh7ky	225	7	of	of	IN
cord-276456-oa6hh7ky	225	8	TMDs	tmd	NNS
cord-276456-oa6hh7ky	225	9	should	should	MD
cord-276456-oa6hh7ky	225	10	destabilize	destabilize	VB
cord-276456-oa6hh7ky	225	11	the	the	DT
cord-276456-oa6hh7ky	225	12	junction	junction	NN
cord-276456-oa6hh7ky	225	13	and	and	CC
cord-276456-oa6hh7ky	225	14	thereby	thereby	RB
cord-276456-oa6hh7ky	225	15	generate	generate	VB
cord-276456-oa6hh7ky	225	16	pores	pore	NNS
cord-276456-oa6hh7ky	225	17	.	.	.
cord-276456-oa6hh7ky	226	1	This	this	DT
cord-276456-oa6hh7ky	226	2	is	be	VBZ
cord-276456-oa6hh7ky	226	3	consistent	consistent	JJ
cord-276456-oa6hh7ky	226	4	with	with	IN
cord-276456-oa6hh7ky	226	5	demonstrations	demonstration	NNS
cord-276456-oa6hh7ky	226	6	that	that	IN
cord-276456-oa6hh7ky	226	7	TMDs	tmd	NNS
cord-276456-oa6hh7ky	226	8	are	be	VBP
cord-276456-oa6hh7ky	226	9	directly	directly	RB
cord-276456-oa6hh7ky	226	10	involved	involve	VBN
cord-276456-oa6hh7ky	226	11	in	in	IN
cord-276456-oa6hh7ky	226	12	pore	pore	NN
cord-276456-oa6hh7ky	226	13	formation	formation	NN
cord-276456-oa6hh7ky	226	14	68	68	CD
cord-276456-oa6hh7ky	226	15	and	and	CC
cord-276456-oa6hh7ky	226	16	with	with	IN
cord-276456-oa6hh7ky	226	17	theory	theory	NN
cord-276456-oa6hh7ky	226	18	that	that	WDT
cord-276456-oa6hh7ky	226	19	predicts	predict	VBZ
cord-276456-oa6hh7ky	226	20	that	that	IN
cord-276456-oa6hh7ky	226	21	pores	pore	NNS
cord-276456-oa6hh7ky	226	22	form	form	NN
cord-276456-oa6hh7ky	226	23	at	at	IN
cord-276456-oa6hh7ky	226	24	the	the	DT
cord-276456-oa6hh7ky	226	25	junction	junction	NN
cord-276456-oa6hh7ky	226	26	.	.	.
cord-276456-oa6hh7ky	227	1	But	but	CC
cord-276456-oa6hh7ky	227	2	why	why	WRB
cord-276456-oa6hh7ky	227	3	TMDs	tmd	NNS
cord-276456-oa6hh7ky	227	4	are	be	VBP
cord-276456-oa6hh7ky	227	5	forced	force	VBN
cord-276456-oa6hh7ky	227	6	through	through	IN
cord-276456-oa6hh7ky	227	7	the	the	DT
cord-276456-oa6hh7ky	227	8	junction	junction	NN
cord-276456-oa6hh7ky	227	9	has	have	VBZ
cord-276456-oa6hh7ky	227	10	not	not	RB
cord-276456-oa6hh7ky	227	11	been	be	VBN
cord-276456-oa6hh7ky	227	12	addressed	address	VBN
cord-276456-oa6hh7ky	227	13	and	and	CC
cord-276456-oa6hh7ky	227	14	the	the	DT
cord-276456-oa6hh7ky	227	15	determinants	determinant	NNS
cord-276456-oa6hh7ky	227	16	of	of	IN
cord-276456-oa6hh7ky	227	17	pore	pore	NN
cord-276456-oa6hh7ky	227	18	properties	property	NNS
cord-276456-oa6hh7ky	227	19	are	be	VBP
cord-276456-oa6hh7ky	227	20	virtually	virtually	RB
cord-276456-oa6hh7ky	227	21	uncharacterized	uncharacterized	JJ
cord-276456-oa6hh7ky	227	22	.	.	.
cord-276456-oa6hh7ky	228	1	For	for	IN
cord-276456-oa6hh7ky	228	2	example	example	NN
cord-276456-oa6hh7ky	228	3	,	,	,
cord-276456-oa6hh7ky	228	4	some	some	DT
cord-276456-oa6hh7ky	228	5	viral	viral	JJ
cord-276456-oa6hh7ky	228	6	fusion	fusion	NN
cord-276456-oa6hh7ky	228	7	proteins	protein	NNS
cord-276456-oa6hh7ky	228	8	,	,	,
cord-276456-oa6hh7ky	228	9	such	such	JJ
cord-276456-oa6hh7ky	228	10	as	as	IN
cord-276456-oa6hh7ky	228	11	HIV-1	HIV-1	NNP
cord-276456-oa6hh7ky	228	12	Env	Env	NNP
cord-276456-oa6hh7ky	228	13	,	,	,
cord-276456-oa6hh7ky	228	14	generate	generate	VBP
cord-276456-oa6hh7ky	228	15	large	large	JJ
cord-276456-oa6hh7ky	228	16	initial	initial	JJ
cord-276456-oa6hh7ky	228	17	pores	pore	NNS
cord-276456-oa6hh7ky	228	18	than	than	IN
cord-276456-oa6hh7ky	228	19	readily	readily	RB
cord-276456-oa6hh7ky	228	20	open	open	JJ
cord-276456-oa6hh7ky	228	21	whereas	whereas	IN
cord-276456-oa6hh7ky	228	22	others	other	NNS
cord-276456-oa6hh7ky	228	23	,	,	,
cord-276456-oa6hh7ky	228	24	such	such	JJ
cord-276456-oa6hh7ky	228	25	as	as	IN
cord-276456-oa6hh7ky	228	26	influenza	influenza	NN
cord-276456-oa6hh7ky	228	27	HA	HA	NNP
cord-276456-oa6hh7ky	228	28	,	,	,
cord-276456-oa6hh7ky	228	29	create	create	VB
cord-276456-oa6hh7ky	228	30	small	small	JJ
cord-276456-oa6hh7ky	228	31	pores	pore	NNS
cord-276456-oa6hh7ky	228	32	that	that	WDT
cord-276456-oa6hh7ky	228	33	generally	generally	RB
cord-276456-oa6hh7ky	228	34	flicker	flicker	VBP
cord-276456-oa6hh7ky	228	35	open	open	JJ
cord-276456-oa6hh7ky	228	36	and	and	CC
cord-276456-oa6hh7ky	228	37	closed	closed	JJ
cord-276456-oa6hh7ky	228	38	before	before	IN
cord-276456-oa6hh7ky	228	39	they	-PRON-	PRP
cord-276456-oa6hh7ky	228	40	enlarge	enlarge	VBP
cord-276456-oa6hh7ky	228	41	.	.	.
cord-276456-oa6hh7ky	229	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	229	2	seems	seem	VBZ
cord-276456-oa6hh7ky	229	3	reasonable	reasonable	JJ
cord-276456-oa6hh7ky	229	4	that	that	IN
cord-276456-oa6hh7ky	229	5	differences	difference	NNS
cord-276456-oa6hh7ky	229	6	in	in	IN
cord-276456-oa6hh7ky	229	7	pores	pore	NNS
cord-276456-oa6hh7ky	229	8	are	be	VBP
cord-276456-oa6hh7ky	229	9	conferred	confer	VBN
cord-276456-oa6hh7ky	229	10	by	by	IN
cord-276456-oa6hh7ky	229	11	the	the	DT
cord-276456-oa6hh7ky	229	12	proteins	protein	NNS
cord-276456-oa6hh7ky	229	13	(	(	-LRB-
cord-276456-oa6hh7ky	229	14	rather	rather	RB
cord-276456-oa6hh7ky	229	15	than	than	IN
cord-276456-oa6hh7ky	229	16	by	by	IN
cord-276456-oa6hh7ky	229	17	the	the	DT
cord-276456-oa6hh7ky	229	18	lipids	lipid	NNS
cord-276456-oa6hh7ky	229	19	)	)	-RRB-
cord-276456-oa6hh7ky	229	20	,	,	,
cord-276456-oa6hh7ky	229	21	but	but	CC
cord-276456-oa6hh7ky	229	22	the	the	DT
cord-276456-oa6hh7ky	229	23	field	field	NN
cord-276456-oa6hh7ky	229	24	has	have	VBZ
cord-276456-oa6hh7ky	229	25	not	not	RB
cord-276456-oa6hh7ky	229	26	formulated	formulate	VBN
cord-276456-oa6hh7ky	229	27	guiding	guide	VBG
cord-276456-oa6hh7ky	229	28	principles	principle	NNS
cord-276456-oa6hh7ky	229	29	as	as	IN
cord-276456-oa6hh7ky	229	30	to	to	IN
cord-276456-oa6hh7ky	229	31	which	which	WDT
cord-276456-oa6hh7ky	229	32	structural	structural	JJ
cord-276456-oa6hh7ky	229	33	features	feature	NNS
cord-276456-oa6hh7ky	229	34	of	of	IN
cord-276456-oa6hh7ky	229	35	a	a	DT
cord-276456-oa6hh7ky	229	36	protein	protein	NN
cord-276456-oa6hh7ky	229	37	control	control	NN
cord-276456-oa6hh7ky	229	38	pore	pore	NN
cord-276456-oa6hh7ky	229	39	properties	property	NNS
cord-276456-oa6hh7ky	229	40	.	.	.
cord-276456-oa6hh7ky	230	1	Because	because	IN
cord-276456-oa6hh7ky	230	2	viral	viral	JJ
cord-276456-oa6hh7ky	230	3	nucleocapsids	nucleocapsid	NNS
cord-276456-oa6hh7ky	230	4	can	can	MD
cord-276456-oa6hh7ky	230	5	only	only	RB
cord-276456-oa6hh7ky	230	6	enter	enter	VB
cord-276456-oa6hh7ky	230	7	cytosol	cytosol	NN
cord-276456-oa6hh7ky	230	8	if	if	IN
cord-276456-oa6hh7ky	230	9	a	a	DT
cord-276456-oa6hh7ky	230	10	pore	pore	NN
cord-276456-oa6hh7ky	230	11	enlarges	enlarge	VBZ
cord-276456-oa6hh7ky	230	12	,	,	,
cord-276456-oa6hh7ky	230	13	these	these	DT
cord-276456-oa6hh7ky	230	14	questions	question	NNS
cord-276456-oa6hh7ky	230	15	are	be	VBP
cord-276456-oa6hh7ky	230	16	potentially	potentially	RB
cord-276456-oa6hh7ky	230	17	of	of	IN
cord-276456-oa6hh7ky	230	18	practical	practical	JJ
cord-276456-oa6hh7ky	230	19	,	,	,
cord-276456-oa6hh7ky	230	20	in	in	IN
cord-276456-oa6hh7ky	230	21	addition	addition	NN
cord-276456-oa6hh7ky	230	22	to	to	IN
cord-276456-oa6hh7ky	230	23	biophysical	biophysical	JJ
cord-276456-oa6hh7ky	230	24	,	,	,
cord-276456-oa6hh7ky	230	25	importance	importance	NN
cord-276456-oa6hh7ky	230	26	.	.	.
cord-276456-oa6hh7ky	231	1	The	the	DT
cord-276456-oa6hh7ky	231	2	SNARE	snare	NN
cord-276456-oa6hh7ky	231	3	complex	complex	NN
cord-276456-oa6hh7ky	231	4	formed	form	VBN
cord-276456-oa6hh7ky	231	5	between	between	IN
cord-276456-oa6hh7ky	231	6	two	two	CD
cord-276456-oa6hh7ky	231	7	fusing	fuse	VBG
cord-276456-oa6hh7ky	231	8	membranes	membrane	NNS
cord-276456-oa6hh7ky	231	9	are	be	VBP
cord-276456-oa6hh7ky	231	10	the	the	DT
cord-276456-oa6hh7ky	231	11	principal	principal	JJ
cord-276456-oa6hh7ky	231	12	fusogens	fusogen	NNS
cord-276456-oa6hh7ky	231	13	of	of	IN
cord-276456-oa6hh7ky	231	14	the	the	DT
cord-276456-oa6hh7ky	231	15	eukaryotic	eukaryotic	JJ
cord-276456-oa6hh7ky	231	16	molecular	molecular	JJ
cord-276456-oa6hh7ky	231	17	machinery	machinery	NN
cord-276456-oa6hh7ky	231	18	that	that	WDT
cord-276456-oa6hh7ky	231	19	mediates	mediate	VBZ
cord-276456-oa6hh7ky	231	20	membrane	membrane	NN
cord-276456-oa6hh7ky	231	21	fusion	fusion	NN
cord-276456-oa6hh7ky	231	22	in	in	IN
cord-276456-oa6hh7ky	231	23	intracellular	intracellular	JJ
cord-276456-oa6hh7ky	231	24	trafficking	traffic	VBG
cord-276456-oa6hh7ky	231	25	pathways	pathway	NNS
cord-276456-oa6hh7ky	231	26	.	.	.
cord-276456-oa6hh7ky	232	1	69	69	CD
cord-276456-oa6hh7ky	233	1	The	the	DT
cord-276456-oa6hh7ky	233	2	SNARE	snare	NN
cord-276456-oa6hh7ky	233	3	complex	complex	NN
cord-276456-oa6hh7ky	233	4	is	be	VBZ
cord-276456-oa6hh7ky	233	5	a	a	DT
cord-276456-oa6hh7ky	233	6	coiled	coiled	JJ
cord-276456-oa6hh7ky	233	7	bundle	bundle	NN
cord-276456-oa6hh7ky	233	8	of	of	IN
cord-276456-oa6hh7ky	233	9	four	four	CD
cord-276456-oa6hh7ky	233	10	parallel	parallel	JJ
cord-276456-oa6hh7ky	233	11	helices	helix	NNS
cord-276456-oa6hh7ky	233	12	provided	provide	VBN
cord-276456-oa6hh7ky	233	13	by	by	IN
cord-276456-oa6hh7ky	233	14	three	three	CD
cord-276456-oa6hh7ky	233	15	or	or	CC
cord-276456-oa6hh7ky	233	16	four	four	CD
cord-276456-oa6hh7ky	233	17	individual	individual	JJ
cord-276456-oa6hh7ky	233	18	SNARE	snare	VB
cord-276456-oa6hh7ky	233	19	protein	protein	NN
cord-276456-oa6hh7ky	233	20	molecules	molecule	NNS
cord-276456-oa6hh7ky	233	21	(	(	-LRB-
cord-276456-oa6hh7ky	233	22	Figure	Figure	NNP
cord-276456-oa6hh7ky	233	23	7	7	CD
cord-276456-oa6hh7ky	233	24	)	)	-RRB-
cord-276456-oa6hh7ky	233	25	.	.	.
cord-276456-oa6hh7ky	234	1	Perhaps	perhaps	RB
cord-276456-oa6hh7ky	234	2	the	the	DT
cord-276456-oa6hh7ky	234	3	best	well	RBS
cord-276456-oa6hh7ky	234	4	studied	study	VBN
cord-276456-oa6hh7ky	234	5	is	be	VBZ
cord-276456-oa6hh7ky	234	6	the	the	DT
cord-276456-oa6hh7ky	234	7	SNARE	snare	NN
cord-276456-oa6hh7ky	234	8	complex	complex	JJ
cord-276456-oa6hh7ky	234	9	mediating	mediate	VBG
cord-276456-oa6hh7ky	234	10	neuronal	neuronal	JJ
cord-276456-oa6hh7ky	234	11	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	234	12	containing	contain	VBG
cord-276456-oa6hh7ky	234	13	four	four	CD
cord-276456-oa6hh7ky	234	14	helices	helix	NNS
cord-276456-oa6hh7ky	234	15	provided	provide	VBN
cord-276456-oa6hh7ky	234	16	by	by	IN
cord-276456-oa6hh7ky	234	17	three	three	CD
cord-276456-oa6hh7ky	234	18	SNARE	snare	NN
cord-276456-oa6hh7ky	234	19	proteins	protein	NNS
cord-276456-oa6hh7ky	234	20	:	:	:
cord-276456-oa6hh7ky	235	1	SNAP-25	SNAP-25	NNS
cord-276456-oa6hh7ky	236	1	(	(	-LRB-
cord-276456-oa6hh7ky	236	2	synaptosome	synaptosome	NNP
cord-276456-oa6hh7ky	236	3	-	-	HYPH
cord-276456-oa6hh7ky	236	4	associated	associate	VBN
cord-276456-oa6hh7ky	236	5	protein	protein	NN
cord-276456-oa6hh7ky	236	6	of	of	IN
cord-276456-oa6hh7ky	236	7	25	25	CD
cord-276456-oa6hh7ky	236	8	kD	kd	JJ
cord-276456-oa6hh7ky	236	9	)	)	-RRB-
cord-276456-oa6hh7ky	236	10	,	,	,
cord-276456-oa6hh7ky	236	11	synaptobrevin-2	synaptobrevin-2	NNP
cord-276456-oa6hh7ky	236	12	,	,	,
cord-276456-oa6hh7ky	236	13	and	and	CC
cord-276456-oa6hh7ky	236	14	syntaxin-1	syntaxin-1	NNP
cord-276456-oa6hh7ky	236	15	.	.	.
cord-276456-oa6hh7ky	237	1	70	70	CD
cord-276456-oa6hh7ky	238	1	The	the	DT
cord-276456-oa6hh7ky	238	2	free	free	JJ
cord-276456-oa6hh7ky	238	3	energy	energy	NN
cord-276456-oa6hh7ky	238	4	generated	generate	VBN
cord-276456-oa6hh7ky	238	5	during	during	IN
cord-276456-oa6hh7ky	238	6	the	the	DT
cord-276456-oa6hh7ky	238	7	assembly	assembly	NN
cord-276456-oa6hh7ky	238	8	of	of	IN
cord-276456-oa6hh7ky	238	9	a	a	DT
cord-276456-oa6hh7ky	238	10	single	single	JJ
cord-276456-oa6hh7ky	238	11	ternary	ternary	JJ
cord-276456-oa6hh7ky	238	12	SNARE	snare	NN
cord-276456-oa6hh7ky	238	13	is	be	VBZ
cord-276456-oa6hh7ky	238	14	estimated	estimate	VBN
cord-276456-oa6hh7ky	238	15	to	to	TO
cord-276456-oa6hh7ky	238	16	be	be	VB
cord-276456-oa6hh7ky	238	17	20	20	CD
cord-276456-oa6hh7ky	238	18	-	-	SYM
cord-276456-oa6hh7ky	238	19	35	35	CD
cord-276456-oa6hh7ky	238	20	k	k	NN
cord-276456-oa6hh7ky	238	21	B	b	NN
cord-276456-oa6hh7ky	238	22	T.	t.	NN
cord-276456-oa6hh7ky	238	23	[	[	-LRB-
cord-276456-oa6hh7ky	238	24	71	71	CD
cord-276456-oa6hh7ky	238	25	]	]	-RRB-
cord-276456-oa6hh7ky	238	26	[	[	-LRB-
cord-276456-oa6hh7ky	238	27	72	72	CD
cord-276456-oa6hh7ky	238	28	]	]	-RRB-
cord-276456-oa6hh7ky	238	29	[	[	-LRB-
cord-276456-oa6hh7ky	238	30	73	73	CD
cord-276456-oa6hh7ky	238	31	]	]	-RRB-
cord-276456-oa6hh7ky	239	1	A	a	DT
cord-276456-oa6hh7ky	239	2	key	key	JJ
cord-276456-oa6hh7ky	239	3	question	question	NN
cord-276456-oa6hh7ky	239	4	is	be	VBZ
cord-276456-oa6hh7ky	239	5	what	what	WDT
cord-276456-oa6hh7ky	239	6	proportion	proportion	NN
cord-276456-oa6hh7ky	239	7	of	of	IN
cord-276456-oa6hh7ky	239	8	the	the	DT
cord-276456-oa6hh7ky	239	9	energy	energy	NN
cord-276456-oa6hh7ky	239	10	of	of	IN
cord-276456-oa6hh7ky	239	11	SNARE	snare	VB
cord-276456-oa6hh7ky	239	12	complex	complex	JJ
cord-276456-oa6hh7ky	239	13	formation	formation	NN
cord-276456-oa6hh7ky	239	14	is	be	VBZ
cord-276456-oa6hh7ky	239	15	directed	direct	VBN
cord-276456-oa6hh7ky	239	16	at	at	IN
cord-276456-oa6hh7ky	239	17	membrane	membrane	NN
cord-276456-oa6hh7ky	239	18	fusion	fusion	NN
cord-276456-oa6hh7ky	239	19	and	and	CC
cord-276456-oa6hh7ky	239	20	what	what	WP
cord-276456-oa6hh7ky	239	21	the	the	DT
cord-276456-oa6hh7ky	239	22	contribution	contribution	NN
cord-276456-oa6hh7ky	239	23	of	of	IN
cord-276456-oa6hh7ky	239	24	the	the	DT
cord-276456-oa6hh7ky	239	25	energetics	energetic	NNS
cord-276456-oa6hh7ky	239	26	of	of	IN
cord-276456-oa6hh7ky	239	27	this	this	DT
cord-276456-oa6hh7ky	239	28	reaction	reaction	NN
cord-276456-oa6hh7ky	239	29	,	,	,
cord-276456-oa6hh7ky	239	30	if	if	IN
cord-276456-oa6hh7ky	239	31	any	any	DT
cord-276456-oa6hh7ky	239	32	,	,	,
cord-276456-oa6hh7ky	239	33	contribute	contribute	VB
cord-276456-oa6hh7ky	239	34	to	to	IN
cord-276456-oa6hh7ky	239	35	membrane	membrane	NN
cord-276456-oa6hh7ky	239	36	docking	docking	NN
cord-276456-oa6hh7ky	239	37	and	and	CC
cord-276456-oa6hh7ky	239	38	tethering	tethering	NN
cord-276456-oa6hh7ky	239	39	.	.	.
cord-276456-oa6hh7ky	240	1	Several	several	JJ
cord-276456-oa6hh7ky	240	2	of	of	IN
cord-276456-oa6hh7ky	240	3	the	the	DT
cord-276456-oa6hh7ky	240	4	proteins	protein	NNS
cord-276456-oa6hh7ky	240	5	engaged	engage	VBN
cord-276456-oa6hh7ky	240	6	in	in	IN
cord-276456-oa6hh7ky	240	7	and/or	and/or	CC
cord-276456-oa6hh7ky	240	8	responsible	responsible	JJ
cord-276456-oa6hh7ky	240	9	for	for	IN
cord-276456-oa6hh7ky	240	10	fusion	fusion	NN
cord-276456-oa6hh7ky	240	11	have	have	VBP
cord-276456-oa6hh7ky	240	12	been	be	VBN
cord-276456-oa6hh7ky	240	13	studied	study	VBN
cord-276456-oa6hh7ky	240	14	at	at	IN
cord-276456-oa6hh7ky	240	15	atomic	atomic	JJ
cord-276456-oa6hh7ky	240	16	resolution	resolution	NN
cord-276456-oa6hh7ky	240	17	with	with	IN
cord-276456-oa6hh7ky	240	18	biophysical	biophysical	JJ
cord-276456-oa6hh7ky	240	19	structural	structural	JJ
cord-276456-oa6hh7ky	240	20	approaches	approach	NNS
cord-276456-oa6hh7ky	240	21	.	.	.
cord-276456-oa6hh7ky	241	1	These	these	DT
cord-276456-oa6hh7ky	241	2	studies	study	NNS
cord-276456-oa6hh7ky	241	3	have	have	VBP
cord-276456-oa6hh7ky	241	4	greatly	greatly	RB
cord-276456-oa6hh7ky	241	5	illuminated	illuminate	VBN
cord-276456-oa6hh7ky	241	6	our	-PRON-	PRP$
cord-276456-oa6hh7ky	241	7	understanding	understanding	NN
cord-276456-oa6hh7ky	241	8	of	of	IN
cord-276456-oa6hh7ky	241	9	the	the	DT
cord-276456-oa6hh7ky	241	10	protein	protein	NN
cord-276456-oa6hh7ky	241	11	machines	machine	NNS
cord-276456-oa6hh7ky	241	12	driving	drive	VBG
cord-276456-oa6hh7ky	241	13	membrane	membrane	NN
cord-276456-oa6hh7ky	241	14	fusion	fusion	NN
cord-276456-oa6hh7ky	241	15	reviewed	review	VBN
cord-276456-oa6hh7ky	241	16	in	in	IN
cord-276456-oa6hh7ky	241	17	Refs	ref	NNS
cord-276456-oa6hh7ky	241	18	.	.	.
cord-276456-oa6hh7ky	242	1	75	75	CD
cord-276456-oa6hh7ky	242	2	and	and	CC
cord-276456-oa6hh7ky	242	3	76	76	CD
cord-276456-oa6hh7ky	242	4	.	.	.
cord-276456-oa6hh7ky	243	1	The	the	DT
cord-276456-oa6hh7ky	243	2	minimal	minimal	JJ
cord-276456-oa6hh7ky	243	3	domains	domain	NNS
cord-276456-oa6hh7ky	243	4	of	of	IN
cord-276456-oa6hh7ky	243	5	SNARE	snare	NN
cord-276456-oa6hh7ky	243	6	proteins	protein	NNS
cord-276456-oa6hh7ky	243	7	that	that	WDT
cord-276456-oa6hh7ky	243	8	can	can	MD
cord-276456-oa6hh7ky	243	9	spontaneously	spontaneously	RB
cord-276456-oa6hh7ky	243	10	engage	engage	VB
cord-276456-oa6hh7ky	243	11	in	in	IN
cord-276456-oa6hh7ky	243	12	a	a	DT
cord-276456-oa6hh7ky	243	13	stable	stable	JJ
cord-276456-oa6hh7ky	243	14	4-helix	4-helix	CD
cord-276456-oa6hh7ky	243	15	SNARE	snare	NN
cord-276456-oa6hh7ky	243	16	complex	complex	NN
cord-276456-oa6hh7ky	243	17	revealed	reveal	VBD
cord-276456-oa6hh7ky	243	18	a	a	DT
cord-276456-oa6hh7ky	243	19	characteristic	characteristic	JJ
cord-276456-oa6hh7ky	243	20	packing	packing	NN
cord-276456-oa6hh7ky	243	21	at	at	IN
cord-276456-oa6hh7ky	243	22	the	the	DT
cord-276456-oa6hh7ky	243	23	core	core	NN
cord-276456-oa6hh7ky	243	24	of	of	IN
cord-276456-oa6hh7ky	243	25	the	the	DT
cord-276456-oa6hh7ky	243	26	SNARE	snare	NN
cord-276456-oa6hh7ky	243	27	complex	complex	NN
cord-276456-oa6hh7ky	243	28	.	.	.
cord-276456-oa6hh7ky	244	1	The	the	DT
cord-276456-oa6hh7ky	244	2	majority	majority	NN
cord-276456-oa6hh7ky	244	3	of	of	IN
cord-276456-oa6hh7ky	244	4	the	the	DT
cord-276456-oa6hh7ky	244	5	packing	packing	NN
cord-276456-oa6hh7ky	244	6	interactions	interaction	NNS
cord-276456-oa6hh7ky	244	7	are	be	VBP
cord-276456-oa6hh7ky	244	8	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	244	9	,	,	,
cord-276456-oa6hh7ky	244	10	however	however	WRB
cord-276456-oa6hh7ky	244	11	there	there	EX
cord-276456-oa6hh7ky	244	12	is	be	VBZ
cord-276456-oa6hh7ky	244	13	an	an	DT
cord-276456-oa6hh7ky	244	14	ionic	ionic	JJ
cord-276456-oa6hh7ky	244	15	layer	layer	NN
cord-276456-oa6hh7ky	244	16	typically	typically	RB
cord-276456-oa6hh7ky	244	17	consisting	consist	VBG
cord-276456-oa6hh7ky	244	18	of	of	IN
cord-276456-oa6hh7ky	244	19	a	a	DT
cord-276456-oa6hh7ky	244	20	single	single	JJ
cord-276456-oa6hh7ky	244	21	arginine	arginine	NN
cord-276456-oa6hh7ky	244	22	and	and	CC
cord-276456-oa6hh7ky	244	23	three	three	CD
cord-276456-oa6hh7ky	244	24	glutamine	glutamine	NN
cord-276456-oa6hh7ky	244	25	residues	residue	NNS
cord-276456-oa6hh7ky	244	26	.	.	.
cord-276456-oa6hh7ky	245	1	70	70	CD
cord-276456-oa6hh7ky	245	2	,	,	,
cord-276456-oa6hh7ky	245	3	74	74	CD
cord-276456-oa6hh7ky	246	1	This	this	DT
cord-276456-oa6hh7ky	246	2	ionic	ionic	JJ
cord-276456-oa6hh7ky	246	3	layer	layer	NN
cord-276456-oa6hh7ky	246	4	is	be	VBZ
cord-276456-oa6hh7ky	246	5	found	find	VBN
cord-276456-oa6hh7ky	246	6	at	at	IN
cord-276456-oa6hh7ky	246	7	the	the	DT
cord-276456-oa6hh7ky	246	8	midpoint	midpoint	NN
cord-276456-oa6hh7ky	246	9	of	of	IN
cord-276456-oa6hh7ky	246	10	the	the	DT
cord-276456-oa6hh7ky	246	11	coiled	coil	VBN
cord-276456-oa6hh7ky	246	12	-	-	HYPH
cord-276456-oa6hh7ky	246	13	coiled	coiled	JJ
cord-276456-oa6hh7ky	246	14	bundle	bundle	NN
cord-276456-oa6hh7ky	246	15	and	and	CC
cord-276456-oa6hh7ky	246	16	hence	hence	RB
cord-276456-oa6hh7ky	246	17	is	be	VBZ
cord-276456-oa6hh7ky	246	18	referred	refer	VBN
cord-276456-oa6hh7ky	246	19	to	to	IN
cord-276456-oa6hh7ky	246	20	as	as	IN
cord-276456-oa6hh7ky	246	21	the	the	DT
cord-276456-oa6hh7ky	246	22	zero	zero	CD
cord-276456-oa6hh7ky	246	23	ionic	ionic	JJ
cord-276456-oa6hh7ky	246	24	layer	layer	NN
cord-276456-oa6hh7ky	246	25	.	.	.
cord-276456-oa6hh7ky	247	1	The	the	DT
cord-276456-oa6hh7ky	247	2	zero	zero	CD
cord-276456-oa6hh7ky	247	3	ionic	ionic	JJ
cord-276456-oa6hh7ky	247	4	layer	layer	NN
cord-276456-oa6hh7ky	247	5	is	be	VBZ
cord-276456-oa6hh7ky	247	6	an	an	DT
cord-276456-oa6hh7ky	247	7	evolutionarily	evolutionarily	RB
cord-276456-oa6hh7ky	247	8	conserved	conserve	VBN
cord-276456-oa6hh7ky	247	9	feature	feature	NN
cord-276456-oa6hh7ky	247	10	of	of	IN
cord-276456-oa6hh7ky	247	11	all	all	DT
cord-276456-oa6hh7ky	247	12	SNARE	snare	NN
cord-276456-oa6hh7ky	247	13	complexes	complex	NNS
cord-276456-oa6hh7ky	247	14	examined	examine	VBN
cord-276456-oa6hh7ky	247	15	to	to	IN
cord-276456-oa6hh7ky	247	16	date	date	NN
cord-276456-oa6hh7ky	247	17	,	,	,
cord-276456-oa6hh7ky	247	18	however	however	RB
cord-276456-oa6hh7ky	247	19	the	the	DT
cord-276456-oa6hh7ky	247	20	functional	functional	JJ
cord-276456-oa6hh7ky	247	21	role	role	NN
cord-276456-oa6hh7ky	247	22	of	of	IN
cord-276456-oa6hh7ky	247	23	this	this	DT
cord-276456-oa6hh7ky	247	24	feature	feature	NN
cord-276456-oa6hh7ky	247	25	is	be	VBZ
cord-276456-oa6hh7ky	247	26	not	not	RB
cord-276456-oa6hh7ky	247	27	known	know	VBN
cord-276456-oa6hh7ky	247	28	.	.	.
cord-276456-oa6hh7ky	248	1	Biophysical	biophysical	JJ
cord-276456-oa6hh7ky	248	2	characterization	characterization	NN
cord-276456-oa6hh7ky	248	3	of	of	IN
cord-276456-oa6hh7ky	248	4	SNARE	snare	NN
cord-276456-oa6hh7ky	248	5	complexes	complex	NNS
cord-276456-oa6hh7ky	248	6	that	that	WDT
cord-276456-oa6hh7ky	248	7	perturb	perturb	VBP
cord-276456-oa6hh7ky	248	8	the	the	DT
cord-276456-oa6hh7ky	248	9	zero	zero	CD
cord-276456-oa6hh7ky	248	10	ionic	ionic	JJ
cord-276456-oa6hh7ky	248	11	layer	layer	NN
cord-276456-oa6hh7ky	248	12	suggest	suggest	VBP
cord-276456-oa6hh7ky	248	13	that	that	IN
cord-276456-oa6hh7ky	248	14	it	-PRON-	PRP
cord-276456-oa6hh7ky	248	15	may	may	MD
cord-276456-oa6hh7ky	248	16	be	be	VB
cord-276456-oa6hh7ky	248	17	important	important	JJ
cord-276456-oa6hh7ky	248	18	for	for	IN
cord-276456-oa6hh7ky	248	19	the	the	DT
cord-276456-oa6hh7ky	248	20	stability	stability	NN
cord-276456-oa6hh7ky	248	21	of	of	IN
cord-276456-oa6hh7ky	248	22	SNARE	snare	NN
cord-276456-oa6hh7ky	248	23	complexes	complex	NNS
cord-276456-oa6hh7ky	248	24	.	.	.
cord-276456-oa6hh7ky	249	1	77	77	CD
cord-276456-oa6hh7ky	250	1	One	one	CD
cord-276456-oa6hh7ky	250	2	idea	idea	NN
cord-276456-oa6hh7ky	250	3	was	be	VBD
cord-276456-oa6hh7ky	250	4	that	that	IN
cord-276456-oa6hh7ky	250	5	this	this	DT
cord-276456-oa6hh7ky	250	6	layer	layer	NN
cord-276456-oa6hh7ky	250	7	could	could	MD
cord-276456-oa6hh7ky	250	8	provide	provide	VB
cord-276456-oa6hh7ky	250	9	an	an	DT
cord-276456-oa6hh7ky	250	10	intervention	intervention	NN
cord-276456-oa6hh7ky	250	11	point	point	NN
cord-276456-oa6hh7ky	250	12	for	for	IN
cord-276456-oa6hh7ky	250	13	SNARE	snare	VB
cord-276456-oa6hh7ky	250	14	complex	complex	JJ
cord-276456-oa6hh7ky	250	15	disassembly	disassembly	NN
cord-276456-oa6hh7ky	250	16	,	,	,
cord-276456-oa6hh7ky	250	17	however	however	RB
cord-276456-oa6hh7ky	250	18	perturbation	perturbation	NN
cord-276456-oa6hh7ky	250	19	of	of	IN
cord-276456-oa6hh7ky	250	20	the	the	DT
cord-276456-oa6hh7ky	250	21	layer	layer	NN
cord-276456-oa6hh7ky	250	22	in	in	IN
cord-276456-oa6hh7ky	250	23	an	an	DT
cord-276456-oa6hh7ky	250	24	in	in	FW
cord-276456-oa6hh7ky	250	25	vitro	vitro	FW
cord-276456-oa6hh7ky	250	26	disassembly	disassembly	NN
cord-276456-oa6hh7ky	250	27	assay	assay	NN
cord-276456-oa6hh7ky	250	28	78	78	CD
cord-276456-oa6hh7ky	250	29	had	have	VBD
cord-276456-oa6hh7ky	250	30	no	no	DT
cord-276456-oa6hh7ky	250	31	discernable	discernable	JJ
cord-276456-oa6hh7ky	250	32	impact	impact	NN
cord-276456-oa6hh7ky	250	33	on	on	IN
cord-276456-oa6hh7ky	250	34	NSF	NSF	NNP
cord-276456-oa6hh7ky	250	35	/	/	SYM
cord-276456-oa6hh7ky	250	36	SNAP	snap	VB
cord-276456-oa6hh7ky	250	37	catalyzed	catalyzed	JJ
cord-276456-oa6hh7ky	250	38	SNARE	snare	NN
cord-276456-oa6hh7ky	250	39	disassembly	disassembly	NN
cord-276456-oa6hh7ky	250	40	.	.	.
cord-276456-oa6hh7ky	251	1	Current	current	JJ
cord-276456-oa6hh7ky	251	2	hypotheses	hypothesis	NNS
cord-276456-oa6hh7ky	251	3	for	for	IN
cord-276456-oa6hh7ky	251	4	how	how	WRB
cord-276456-oa6hh7ky	251	5	polar	polar	JJ
cord-276456-oa6hh7ky	251	6	zero	zero	CD
cord-276456-oa6hh7ky	251	7	layer	layer	NN
cord-276456-oa6hh7ky	251	8	residues	residue	NNS
cord-276456-oa6hh7ky	251	9	might	may	MD
cord-276456-oa6hh7ky	251	10	impact	impact	VB
cord-276456-oa6hh7ky	251	11	SNARE	snare	NN
cord-276456-oa6hh7ky	251	12	function	function	NN
cord-276456-oa6hh7ky	251	13	favor	favor	VBP
cord-276456-oa6hh7ky	251	14	potential	potential	JJ
cord-276456-oa6hh7ky	251	15	role(s	role(s	NNP
cord-276456-oa6hh7ky	251	16	)	)	-RRB-
cord-276456-oa6hh7ky	251	17	in	in	IN
cord-276456-oa6hh7ky	251	18	SNARE	snare	NN
cord-276456-oa6hh7ky	251	19	complex	complex	JJ
cord-276456-oa6hh7ky	251	20	assembly	assembly	NN
cord-276456-oa6hh7ky	251	21	,	,	,
cord-276456-oa6hh7ky	251	22	such	such	JJ
cord-276456-oa6hh7ky	251	23	as	as	IN
cord-276456-oa6hh7ky	251	24	the	the	DT
cord-276456-oa6hh7ky	251	25	suggestion	suggestion	NN
cord-276456-oa6hh7ky	251	26	that	that	IN
cord-276456-oa6hh7ky	251	27	a	a	DT
cord-276456-oa6hh7ky	251	28	polar	polar	JJ
cord-276456-oa6hh7ky	251	29	zero	zero	CD
cord-276456-oa6hh7ky	251	30	layer	layer	NN
cord-276456-oa6hh7ky	251	31	helps	help	VBZ
cord-276456-oa6hh7ky	251	32	align	align	VB
cord-276456-oa6hh7ky	251	33	assembly	assembly	NN
cord-276456-oa6hh7ky	251	34	of	of	IN
cord-276456-oa6hh7ky	251	35	the	the	DT
cord-276456-oa6hh7ky	251	36	SNARE	snare	NN
cord-276456-oa6hh7ky	251	37	helices	helix	NNS
cord-276456-oa6hh7ky	251	38	in	in	IN
cord-276456-oa6hh7ky	251	39	register	register	NN
cord-276456-oa6hh7ky	251	40	,	,	,
cord-276456-oa6hh7ky	251	41	or	or	CC
cord-276456-oa6hh7ky	251	42	in	in	IN
cord-276456-oa6hh7ky	251	43	other	other	JJ
cord-276456-oa6hh7ky	251	44	downstream	downstream	JJ
cord-276456-oa6hh7ky	251	45	functions	function	NNS
cord-276456-oa6hh7ky	251	46	of	of	IN
cord-276456-oa6hh7ky	251	47	the	the	DT
cord-276456-oa6hh7ky	251	48	SNARE	snare	NN
cord-276456-oa6hh7ky	251	49	complex	complex	NN
cord-276456-oa6hh7ky	251	50	.	.	.
cord-276456-oa6hh7ky	252	1	Mutagenesis	Mutagenesis	NNP
cord-276456-oa6hh7ky	252	2	studies	study	NNS
cord-276456-oa6hh7ky	252	3	of	of	IN
cord-276456-oa6hh7ky	252	4	the	the	DT
cord-276456-oa6hh7ky	252	5	zero	zero	CD
cord-276456-oa6hh7ky	252	6	ionic	ionic	JJ
cord-276456-oa6hh7ky	252	7	layer	layer	NN
cord-276456-oa6hh7ky	252	8	in	in	IN
cord-276456-oa6hh7ky	252	9	different	different	JJ
cord-276456-oa6hh7ky	252	10	systems	system	NNS
cord-276456-oa6hh7ky	252	11	suggest	suggest	VBP
cord-276456-oa6hh7ky	252	12	different	different	JJ
cord-276456-oa6hh7ky	252	13	effects	effect	NNS
cord-276456-oa6hh7ky	252	14	,	,	,
cord-276456-oa6hh7ky	252	15	but	but	CC
cord-276456-oa6hh7ky	252	16	they	-PRON-	PRP
cord-276456-oa6hh7ky	252	17	are	be	VBP
cord-276456-oa6hh7ky	252	18	all	all	DT
cord-276456-oa6hh7ky	252	19	relatively	relatively	RB
cord-276456-oa6hh7ky	252	20	subtle	subtle	JJ
cord-276456-oa6hh7ky	252	21	.	.	.
cord-276456-oa6hh7ky	253	1	79	79	CD
cord-276456-oa6hh7ky	254	1	,	,	,
cord-276456-oa6hh7ky	254	2	80	80	CD
cord-276456-oa6hh7ky	255	1	Clearly	clearly	RB
cord-276456-oa6hh7ky	255	2	,	,	,
cord-276456-oa6hh7ky	255	3	the	the	DT
cord-276456-oa6hh7ky	255	4	influence	influence	NN
cord-276456-oa6hh7ky	255	5	of	of	IN
cord-276456-oa6hh7ky	255	6	particular	particular	JJ
cord-276456-oa6hh7ky	255	7	residues	residue	NNS
cord-276456-oa6hh7ky	255	8	may	may	MD
cord-276456-oa6hh7ky	255	9	vary	vary	VB
cord-276456-oa6hh7ky	255	10	according	accord	VBG
cord-276456-oa6hh7ky	255	11	to	to	IN
cord-276456-oa6hh7ky	255	12	the	the	DT
cord-276456-oa6hh7ky	255	13	individual	individual	JJ
cord-276456-oa6hh7ky	255	14	SNARE	snare	VB
cord-276456-oa6hh7ky	255	15	complex	complex	JJ
cord-276456-oa6hh7ky	255	16	in	in	IN
cord-276456-oa6hh7ky	255	17	question	question	NN
cord-276456-oa6hh7ky	255	18	and	and	CC
cord-276456-oa6hh7ky	255	19	the	the	DT
cord-276456-oa6hh7ky	255	20	local	local	JJ
cord-276456-oa6hh7ky	255	21	parameters	parameter	NNS
cord-276456-oa6hh7ky	255	22	governing	govern	VBG
cord-276456-oa6hh7ky	255	23	the	the	DT
cord-276456-oa6hh7ky	255	24	assembly	assembly	NN
cord-276456-oa6hh7ky	255	25	of	of	IN
cord-276456-oa6hh7ky	255	26	a	a	DT
cord-276456-oa6hh7ky	255	27	particular	particular	JJ
cord-276456-oa6hh7ky	255	28	cognate	cognate	JJ
cord-276456-oa6hh7ky	255	29	SNARE	snare	NN
cord-276456-oa6hh7ky	255	30	complex	complex	JJ
cord-276456-oa6hh7ky	255	31	.	.	.
cord-276456-oa6hh7ky	256	1	Structures	structure	NNS
cord-276456-oa6hh7ky	256	2	of	of	IN
cord-276456-oa6hh7ky	256	3	the	the	DT
cord-276456-oa6hh7ky	256	4	individual	individual	JJ
cord-276456-oa6hh7ky	256	5	SNARE	snare	NN
cord-276456-oa6hh7ky	256	6	proteins	protein	NNS
cord-276456-oa6hh7ky	256	7	have	have	VBP
cord-276456-oa6hh7ky	256	8	been	be	VBN
cord-276456-oa6hh7ky	256	9	tremendously	tremendously	RB
cord-276456-oa6hh7ky	256	10	stimulating	stimulate	VBG
cord-276456-oa6hh7ky	256	11	in	in	IN
cord-276456-oa6hh7ky	256	12	posing	pose	VBG
cord-276456-oa6hh7ky	256	13	novel	novel	JJ
cord-276456-oa6hh7ky	256	14	questions	question	NNS
cord-276456-oa6hh7ky	256	15	.	.	.
cord-276456-oa6hh7ky	257	1	The	the	DT
cord-276456-oa6hh7ky	257	2	coiled	coiled	JJ
cord-276456-oa6hh7ky	257	3	-	-	HYPH
cord-276456-oa6hh7ky	257	4	coil	coil	NN
cord-276456-oa6hh7ky	257	5	a	a	DT
cord-276456-oa6hh7ky	257	6	-	-	HYPH
cord-276456-oa6hh7ky	257	7	helix	helix	NN
cord-276456-oa6hh7ky	257	8	of	of	IN
cord-276456-oa6hh7ky	257	9	synaptobrevin	synaptobrevin	NNP
cord-276456-oa6hh7ky	257	10	extends	extend	VBZ
cord-276456-oa6hh7ky	257	11	to	to	IN
cord-276456-oa6hh7ky	257	12	the	the	DT
cord-276456-oa6hh7ky	257	13	most	most	JJS
cord-276456-oa6hh7ky	257	14	membrane	membrane	NN
cord-276456-oa6hh7ky	257	15	proximal	proximal	JJ
cord-276456-oa6hh7ky	257	16	residue	residue	NN
cord-276456-oa6hh7ky	257	17	,	,	,
cord-276456-oa6hh7ky	257	18	lysine	lysine	NN
cord-276456-oa6hh7ky	257	19	87	87	CD
cord-276456-oa6hh7ky	258	1	and	and	CC
cord-276456-oa6hh7ky	258	2	this	this	DT
cord-276456-oa6hh7ky	258	3	residue	residue	NN
cord-276456-oa6hh7ky	258	4	is	be	VBZ
cord-276456-oa6hh7ky	258	5	also	also	RB
cord-276456-oa6hh7ky	258	6	part	part	NN
cord-276456-oa6hh7ky	258	7	of	of	IN
cord-276456-oa6hh7ky	258	8	the	the	DT
cord-276456-oa6hh7ky	258	9	extended	extended	JJ
cord-276456-oa6hh7ky	258	10	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	258	11	helix	helix	NN
cord-276456-oa6hh7ky	258	12	.	.	.
cord-276456-oa6hh7ky	259	1	The	the	DT
cord-276456-oa6hh7ky	259	2	energetics	energetic	NNS
cord-276456-oa6hh7ky	259	3	and	and	CC
cord-276456-oa6hh7ky	259	4	topology	topology	NN
cord-276456-oa6hh7ky	259	5	of	of	IN
cord-276456-oa6hh7ky	259	6	SNARE	snare	VB
cord-276456-oa6hh7ky	259	7	complex	complex	JJ
cord-276456-oa6hh7ky	259	8	formation	formation	NN
cord-276456-oa6hh7ky	259	9	may	may	MD
cord-276456-oa6hh7ky	259	10	influence	influence	VB
cord-276456-oa6hh7ky	259	11	local	local	JJ
cord-276456-oa6hh7ky	259	12	bending	bending	NN
cord-276456-oa6hh7ky	259	13	of	of	IN
cord-276456-oa6hh7ky	259	14	the	the	DT
cord-276456-oa6hh7ky	259	15	a	a	DT
cord-276456-oa6hh7ky	259	16	-	-	HYPH
cord-276456-oa6hh7ky	259	17	helix	helix	NN
cord-276456-oa6hh7ky	259	18	at	at	IN
cord-276456-oa6hh7ky	259	19	the	the	DT
cord-276456-oa6hh7ky	259	20	interfacial	interfacial	JJ
cord-276456-oa6hh7ky	259	21	region	region	NN
cord-276456-oa6hh7ky	259	22	,	,	,
cord-276456-oa6hh7ky	259	23	which	which	WDT
cord-276456-oa6hh7ky	259	24	in	in	IN
cord-276456-oa6hh7ky	259	25	turn	turn	NN
cord-276456-oa6hh7ky	259	26	could	could	MD
cord-276456-oa6hh7ky	259	27	generate	generate	VB
cord-276456-oa6hh7ky	259	28	local	local	JJ
cord-276456-oa6hh7ky	259	29	membrane	membrane	NN
cord-276456-oa6hh7ky	259	30	destabilization	destabilization	NN
cord-276456-oa6hh7ky	259	31	to	to	TO
cord-276456-oa6hh7ky	259	32	aid	aid	VB
cord-276456-oa6hh7ky	259	33	fusion	fusion	NN
cord-276456-oa6hh7ky	259	34	(	(	-LRB-
cord-276456-oa6hh7ky	259	35	Figure	figure	NN
cord-276456-oa6hh7ky	259	36	8)	8)	NN
cord-276456-oa6hh7ky	259	37	.	.	.
cord-276456-oa6hh7ky	260	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	260	2	is	be	VBZ
cord-276456-oa6hh7ky	260	3	not	not	RB
cord-276456-oa6hh7ky	260	4	known	know	VBN
cord-276456-oa6hh7ky	260	5	how	how	WRB
cord-276456-oa6hh7ky	260	6	the	the	DT
cord-276456-oa6hh7ky	260	7	membrane	membrane	NN
cord-276456-oa6hh7ky	260	8	itself	-PRON-	PRP
cord-276456-oa6hh7ky	260	9	may	may	MD
cord-276456-oa6hh7ky	260	10	locally	locally	RB
cord-276456-oa6hh7ky	260	11	influence	influence	VB
cord-276456-oa6hh7ky	260	12	the	the	DT
cord-276456-oa6hh7ky	260	13	structure	structure	NN
cord-276456-oa6hh7ky	260	14	of	of	IN
cord-276456-oa6hh7ky	260	15	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	260	16	portions	portion	NNS
cord-276456-oa6hh7ky	260	17	of	of	IN
cord-276456-oa6hh7ky	260	18	synpatobrevin	synpatobrevin	NNS
cord-276456-oa6hh7ky	260	19	or	or	CC
cord-276456-oa6hh7ky	260	20	other	other	JJ
cord-276456-oa6hh7ky	260	21	proteins	protein	NNS
cord-276456-oa6hh7ky	260	22	involved	involve	VBN
cord-276456-oa6hh7ky	260	23	in	in	IN
cord-276456-oa6hh7ky	260	24	fusion	fusion	NN
cord-276456-oa6hh7ky	260	25	.	.	.
cord-276456-oa6hh7ky	261	1	A	a	DT
cord-276456-oa6hh7ky	261	2	recent	recent	JJ
cord-276456-oa6hh7ky	261	3	structure	structure	NN
cord-276456-oa6hh7ky	261	4	of	of	IN
cord-276456-oa6hh7ky	261	5	lipid	lipid	NN
cord-276456-oa6hh7ky	261	6	-	-	HYPH
cord-276456-oa6hh7ky	261	7	bound	bind	VBN
cord-276456-oa6hh7ky	261	8	synpatobrevin	synpatobrevin	XX
cord-276456-oa6hh7ky	261	9	suggests	suggest	VBZ
cord-276456-oa6hh7ky	261	10	that	that	IN
cord-276456-oa6hh7ky	261	11	the	the	DT
cord-276456-oa6hh7ky	261	12	amphipathic	amphipathic	NNP
cord-276456-oa6hh7ky	261	13	helix	helix	NNP
cord-276456-oa6hh7ky	261	14	1	1	CD
cord-276456-oa6hh7ky	261	15	of	of	IN
cord-276456-oa6hh7ky	261	16	synpatobrevin	synpatobrevin	NNPS
cord-276456-oa6hh7ky	261	17	may	may	MD
cord-276456-oa6hh7ky	261	18	lie	lie	VB
cord-276456-oa6hh7ky	261	19	on	on	IN
cord-276456-oa6hh7ky	261	20	the	the	DT
cord-276456-oa6hh7ky	261	21	surface	surface	NN
cord-276456-oa6hh7ky	261	22	of	of	IN
cord-276456-oa6hh7ky	261	23	the	the	DT
cord-276456-oa6hh7ky	261	24	membrane	membrane	NN
cord-276456-oa6hh7ky	261	25	,	,	,
cord-276456-oa6hh7ky	261	26	81	81	CD
cord-276456-oa6hh7ky	261	27	providing	provide	VBG
cord-276456-oa6hh7ky	261	28	a	a	DT
cord-276456-oa6hh7ky	261	29	molecular	molecular	JJ
cord-276456-oa6hh7ky	261	30	explanation	explanation	NN
cord-276456-oa6hh7ky	261	31	of	of	IN
cord-276456-oa6hh7ky	261	32	the	the	DT
cord-276456-oa6hh7ky	261	33	observation	observation	NN
cord-276456-oa6hh7ky	261	34	that	that	IN
cord-276456-oa6hh7ky	261	35	the	the	DT
cord-276456-oa6hh7ky	261	36	membrane	membrane	NN
cord-276456-oa6hh7ky	261	37	may	may	MD
cord-276456-oa6hh7ky	261	38	influence	influence	VB
cord-276456-oa6hh7ky	261	39	the	the	DT
cord-276456-oa6hh7ky	261	40	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	261	41	portion	portion	NN
cord-276456-oa6hh7ky	261	42	of	of	IN
cord-276456-oa6hh7ky	261	43	synaptobrevin	synaptobrevin	NNS
cord-276456-oa6hh7ky	261	44	to	to	TO
cord-276456-oa6hh7ky	261	45	adopt	adopt	VB
cord-276456-oa6hh7ky	261	46	conformations	conformation	NNS
cord-276456-oa6hh7ky	261	47	not	not	RB
cord-276456-oa6hh7ky	261	48	observed	observe	VBN
cord-276456-oa6hh7ky	261	49	in	in	IN
cord-276456-oa6hh7ky	261	50	the	the	DT
cord-276456-oa6hh7ky	261	51	absence	absence	NN
cord-276456-oa6hh7ky	261	52	of	of	IN
cord-276456-oa6hh7ky	261	53	lipid	lipid	NN
cord-276456-oa6hh7ky	261	54	.	.	.
cord-276456-oa6hh7ky	262	1	82	82	CD
cord-276456-oa6hh7ky	263	1	Some	some	DT
cord-276456-oa6hh7ky	263	2	SNAREs	snare	NNS
cord-276456-oa6hh7ky	263	3	contain	contain	VBP
cord-276456-oa6hh7ky	263	4	independently	independently	RB
cord-276456-oa6hh7ky	263	5	folded	fold	VBN
cord-276456-oa6hh7ky	263	6	NH	NH	NNP
cord-276456-oa6hh7ky	263	7	2	2	CD
cord-276456-oa6hh7ky	263	8	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	263	9	domains	domain	NNS
cord-276456-oa6hh7ky	263	10	together	together	RB
cord-276456-oa6hh7ky	263	11	with	with	IN
cord-276456-oa6hh7ky	263	12	additional	additional	JJ
cord-276456-oa6hh7ky	263	13	unstructured	unstructured	JJ
cord-276456-oa6hh7ky	263	14	linker	linker	NN
cord-276456-oa6hh7ky	263	15	regions	region	NNS
cord-276456-oa6hh7ky	263	16	of	of	IN
cord-276456-oa6hh7ky	263	17	significant	significant	JJ
cord-276456-oa6hh7ky	263	18	length	length	NN
cord-276456-oa6hh7ky	263	19	.	.	.
cord-276456-oa6hh7ky	264	1	The	the	DT
cord-276456-oa6hh7ky	264	2	presence	presence	NN
cord-276456-oa6hh7ky	264	3	of	of	IN
cord-276456-oa6hh7ky	264	4	such	such	JJ
cord-276456-oa6hh7ky	264	5	domains	domain	NNS
cord-276456-oa6hh7ky	264	6	and	and	CC
cord-276456-oa6hh7ky	264	7	their	-PRON-	PRP$
cord-276456-oa6hh7ky	264	8	ability	ability	NN
cord-276456-oa6hh7ky	264	9	to	to	TO
cord-276456-oa6hh7ky	264	10	interact	interact	VB
cord-276456-oa6hh7ky	264	11	inter	inter	JJ
cord-276456-oa6hh7ky	264	12	-	-	JJ
cord-276456-oa6hh7ky	264	13	and	and	CC
cord-276456-oa6hh7ky	264	14	intra	intra	RB
cord-276456-oa6hh7ky	264	15	-	-	JJ
cord-276456-oa6hh7ky	264	16	molecularly	molecularly	RB
cord-276456-oa6hh7ky	264	17	significantly	significantly	RB
cord-276456-oa6hh7ky	264	18	increases	increase	VBZ
cord-276456-oa6hh7ky	264	19	the	the	DT
cord-276456-oa6hh7ky	264	20	complexity	complexity	NN
cord-276456-oa6hh7ky	264	21	of	of	IN
cord-276456-oa6hh7ky	264	22	SNARE	snare	VB
cord-276456-oa6hh7ky	264	23	complex	complex	JJ
cord-276456-oa6hh7ky	264	24	formation	formation	NN
cord-276456-oa6hh7ky	264	25	and	and	CC
cord-276456-oa6hh7ky	264	26	the	the	DT
cord-276456-oa6hh7ky	264	27	ability	ability	NN
cord-276456-oa6hh7ky	264	28	of	of	IN
cord-276456-oa6hh7ky	264	29	the	the	DT
cord-276456-oa6hh7ky	264	30	SNARE	snare	NN
cord-276456-oa6hh7ky	264	31	proteins	protein	NNS
cord-276456-oa6hh7ky	264	32	to	to	TO
cord-276456-oa6hh7ky	264	33	drive	drive	VB
cord-276456-oa6hh7ky	264	34	membrane	membrane	NN
cord-276456-oa6hh7ky	264	35	fusion	fusion	NN
cord-276456-oa6hh7ky	264	36	.	.	.
cord-276456-oa6hh7ky	265	1	Syntaxin	Syntaxin	NNP
cord-276456-oa6hh7ky	265	2	contains	contain	VBZ
cord-276456-oa6hh7ky	265	3	a	a	DT
cord-276456-oa6hh7ky	265	4	linker	linker	NN
cord-276456-oa6hh7ky	265	5	region	region	NN
cord-276456-oa6hh7ky	265	6	connecting	connect	VBG
cord-276456-oa6hh7ky	265	7	the	the	DT
cord-276456-oa6hh7ky	265	8	SNARE	snare	NN
cord-276456-oa6hh7ky	265	9	domain	domain	NN
cord-276456-oa6hh7ky	265	10	with	with	IN
cord-276456-oa6hh7ky	265	11	the	the	DT
cord-276456-oa6hh7ky	265	12	H	H	NNP
cord-276456-oa6hh7ky	265	13	ABC	ABC	NNP
cord-276456-oa6hh7ky	265	14	NH	NH	NNP
cord-276456-oa6hh7ky	265	15	2	2	CD
cord-276456-oa6hh7ky	265	16	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	265	17	domain	domain	NN
cord-276456-oa6hh7ky	265	18	.	.	.
cord-276456-oa6hh7ky	266	1	Fully	fully	RB
cord-276456-oa6hh7ky	266	2	extended	extend	VBN
cord-276456-oa6hh7ky	266	3	,	,	,
cord-276456-oa6hh7ky	266	4	this	this	DT
cord-276456-oa6hh7ky	266	5	region	region	NN
cord-276456-oa6hh7ky	266	6	may	may	MD
cord-276456-oa6hh7ky	266	7	be	be	VB
cord-276456-oa6hh7ky	266	8	up	up	IN
cord-276456-oa6hh7ky	266	9	to	to	IN
cord-276456-oa6hh7ky	266	10	approximately	approximately	RB
cord-276456-oa6hh7ky	266	11	120	120	CD
cord-276456-oa6hh7ky	266	12	Å	å	NN
cord-276456-oa6hh7ky	266	13	in	in	IN
cord-276456-oa6hh7ky	266	14	length	length	NN
cord-276456-oa6hh7ky	266	15	(	(	-LRB-
cord-276456-oa6hh7ky	266	16	Figure	figure	NN
cord-276456-oa6hh7ky	266	17	9	9	CD
cord-276456-oa6hh7ky	266	18	)	)	-RRB-
cord-276456-oa6hh7ky	266	19	.	.	.
cord-276456-oa6hh7ky	267	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	267	2	is	be	VBZ
cord-276456-oa6hh7ky	267	3	currently	currently	RB
cord-276456-oa6hh7ky	267	4	unknown	unknown	JJ
cord-276456-oa6hh7ky	267	5	whether	whether	IN
cord-276456-oa6hh7ky	267	6	there	there	EX
cord-276456-oa6hh7ky	267	7	are	be	VBP
cord-276456-oa6hh7ky	267	8	proteins	protein	NNS
cord-276456-oa6hh7ky	267	9	that	that	WDT
cord-276456-oa6hh7ky	267	10	selectively	selectively	RB
cord-276456-oa6hh7ky	267	11	bind	bind	VBP
cord-276456-oa6hh7ky	267	12	to	to	IN
cord-276456-oa6hh7ky	267	13	or	or	CC
cord-276456-oa6hh7ky	267	14	regulate	regulate	VB
cord-276456-oa6hh7ky	267	15	this	this	DT
cord-276456-oa6hh7ky	267	16	region	region	NN
cord-276456-oa6hh7ky	267	17	.	.	.
cord-276456-oa6hh7ky	268	1	In	in	IN
cord-276456-oa6hh7ky	268	2	contrast	contrast	NN
cord-276456-oa6hh7ky	268	3	to	to	IN
cord-276456-oa6hh7ky	268	4	synaptobrevin	synaptobrevin	NNP
cord-276456-oa6hh7ky	268	5	,	,	,
cord-276456-oa6hh7ky	268	6	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	268	7	has	have	VBZ
cord-276456-oa6hh7ky	268	8	an	an	DT
cord-276456-oa6hh7ky	268	9	slightly	slightly	RB
cord-276456-oa6hh7ky	268	10	extended	extended	JJ
cord-276456-oa6hh7ky	268	11	membrane	membrane	NN
cord-276456-oa6hh7ky	268	12	proximal	proximal	JJ
cord-276456-oa6hh7ky	268	13	region	region	NN
cord-276456-oa6hh7ky	268	14	that	that	WDT
cord-276456-oa6hh7ky	268	15	may	may	MD
cord-276456-oa6hh7ky	268	16	not	not	RB
cord-276456-oa6hh7ky	268	17	be	be	VB
cord-276456-oa6hh7ky	268	18	part	part	NN
cord-276456-oa6hh7ky	268	19	of	of	IN
cord-276456-oa6hh7ky	268	20	the	the	DT
cord-276456-oa6hh7ky	268	21	initial	initial	JJ
cord-276456-oa6hh7ky	268	22	core	core	NN
cord-276456-oa6hh7ky	268	23	SNARE	snare	VB
cord-276456-oa6hh7ky	268	24	complex	complex	JJ
cord-276456-oa6hh7ky	268	25	structure	structure	NN
cord-276456-oa6hh7ky	268	26	(	(	-LRB-
cord-276456-oa6hh7ky	268	27	residues	residue	NNS
cord-276456-oa6hh7ky	268	28	260	260	CD
cord-276456-oa6hh7ky	268	29	-	-	HYPH
cord-276456-oa6hh7ky	268	30	265	265	CD
cord-276456-oa6hh7ky	268	31	)	)	-RRB-
cord-276456-oa6hh7ky	268	32	.	.	.
cord-276456-oa6hh7ky	269	1	The	the	DT
cord-276456-oa6hh7ky	269	2	post	post	JJ
cord-276456-oa6hh7ky	269	3	-	-	JJ
cord-276456-oa6hh7ky	269	4	fusion	fusion	JJ
cord-276456-oa6hh7ky	269	5	SNARE	snare	NN
cord-276456-oa6hh7ky	269	6	complex	complex	NN
cord-276456-oa6hh7ky	269	7	shows	show	VBZ
cord-276456-oa6hh7ky	269	8	this	this	DT
cord-276456-oa6hh7ky	269	9	region	region	NN
cord-276456-oa6hh7ky	269	10	adopts	adopt	VBZ
cord-276456-oa6hh7ky	269	11	an	an	DT
cord-276456-oa6hh7ky	269	12	a	a	DT
cord-276456-oa6hh7ky	269	13	-	-	HYPH
cord-276456-oa6hh7ky	269	14	helical	helical	JJ
cord-276456-oa6hh7ky	269	15	structure	structure	NN
cord-276456-oa6hh7ky	269	16	that	that	WDT
cord-276456-oa6hh7ky	269	17	directly	directly	RB
cord-276456-oa6hh7ky	269	18	links	link	VBZ
cord-276456-oa6hh7ky	269	19	the	the	DT
cord-276456-oa6hh7ky	269	20	SNARE	snare	NN
cord-276456-oa6hh7ky	269	21	complex	complex	JJ
cord-276456-oa6hh7ky	269	22	a	a	DT
cord-276456-oa6hh7ky	269	23	-	-	HYPH
cord-276456-oa6hh7ky	269	24	helix	helix	NN
cord-276456-oa6hh7ky	269	25	to	to	IN
cord-276456-oa6hh7ky	269	26	the	the	DT
cord-276456-oa6hh7ky	269	27	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	269	28	a	a	DT
cord-276456-oa6hh7ky	269	29	-	-	HYPH
cord-276456-oa6hh7ky	269	30	helix	helix	NN
cord-276456-oa6hh7ky	269	31	.	.	.
cord-276456-oa6hh7ky	270	1	The	the	DT
cord-276456-oa6hh7ky	270	2	local	local	JJ
cord-276456-oa6hh7ky	270	3	secondary	secondary	JJ
cord-276456-oa6hh7ky	270	4	structure	structure	NN
cord-276456-oa6hh7ky	270	5	adopted	adopt	VBN
cord-276456-oa6hh7ky	270	6	by	by	IN
cord-276456-oa6hh7ky	270	7	these	these	DT
cord-276456-oa6hh7ky	270	8	residues	residue	NNS
cord-276456-oa6hh7ky	270	9	prior	prior	RB
cord-276456-oa6hh7ky	270	10	to	to	IN
cord-276456-oa6hh7ky	270	11	fusion	fusion	NN
cord-276456-oa6hh7ky	270	12	is	be	VBZ
cord-276456-oa6hh7ky	270	13	unknown	unknown	JJ
cord-276456-oa6hh7ky	270	14	;	;	:
cord-276456-oa6hh7ky	270	15	secondary	secondary	JJ
cord-276456-oa6hh7ky	270	16	structural	structural	JJ
cord-276456-oa6hh7ky	270	17	predictions	prediction	NNS
cord-276456-oa6hh7ky	270	18	suggest	suggest	VBP
cord-276456-oa6hh7ky	270	19	the	the	DT
cord-276456-oa6hh7ky	270	20	region	region	NN
cord-276456-oa6hh7ky	270	21	is	be	VBZ
cord-276456-oa6hh7ky	270	22	unstructured	unstructured	JJ
cord-276456-oa6hh7ky	270	23	and	and	CC
cord-276456-oa6hh7ky	270	24	could	could	MD
cord-276456-oa6hh7ky	270	25	conceivably	conceivably	RB
cord-276456-oa6hh7ky	270	26	act	act	VB
cord-276456-oa6hh7ky	270	27	as	as	IN
cord-276456-oa6hh7ky	270	28	a	a	DT
cord-276456-oa6hh7ky	270	29	hinge	hinge	NN
cord-276456-oa6hh7ky	270	30	facilitating	facilitate	VBG
cord-276456-oa6hh7ky	270	31	the	the	DT
cord-276456-oa6hh7ky	270	32	molecule	molecule	NN
cord-276456-oa6hh7ky	270	33	to	to	TO
cord-276456-oa6hh7ky	270	34	sample	sample	VB
cord-276456-oa6hh7ky	270	35	up	up	RP
cord-276456-oa6hh7ky	270	36	to	to	IN
cord-276456-oa6hh7ky	270	37	a	a	DT
cord-276456-oa6hh7ky	270	38	290	290	CD
cord-276456-oa6hh7ky	270	39	Å	å	NN
cord-276456-oa6hh7ky	270	40	radius	radius	NN
cord-276456-oa6hh7ky	270	41	of	of	IN
cord-276456-oa6hh7ky	270	42	the	the	DT
cord-276456-oa6hh7ky	270	43	membrane	membrane	NN
cord-276456-oa6hh7ky	270	44	proximal	proximal	JJ
cord-276456-oa6hh7ky	270	45	area	area	NN
cord-276456-oa6hh7ky	270	46	(	(	-LRB-
cord-276456-oa6hh7ky	270	47	Figure	figure	NN
cord-276456-oa6hh7ky	270	48	10	10	CD
cord-276456-oa6hh7ky	270	49	)	)	-RRB-
cord-276456-oa6hh7ky	270	50	.	.	.
cord-276456-oa6hh7ky	271	1	There	there	EX
cord-276456-oa6hh7ky	271	2	is	be	VBZ
cord-276456-oa6hh7ky	271	3	evidence	evidence	NN
cord-276456-oa6hh7ky	271	4	for	for	IN
cord-276456-oa6hh7ky	271	5	an	an	DT
cord-276456-oa6hh7ky	271	6	initial	initial	JJ
cord-276456-oa6hh7ky	271	7	NH	NH	NNP
cord-276456-oa6hh7ky	271	8	2	2	CD
cord-276456-oa6hh7ky	271	9	-terminal	-terminal	JJ
cord-276456-oa6hh7ky	271	10	interaction	interaction	NN
cord-276456-oa6hh7ky	271	11	between	between	IN
cord-276456-oa6hh7ky	271	12	the	the	DT
cord-276456-oa6hh7ky	271	13	SNARE	snare	NN
cord-276456-oa6hh7ky	271	14	proteins	protein	NNS
cord-276456-oa6hh7ky	271	15	,	,	,
cord-276456-oa6hh7ky	271	16	but	but	CC
cord-276456-oa6hh7ky	271	17	the	the	DT
cord-276456-oa6hh7ky	271	18	final	final	JJ
cord-276456-oa6hh7ky	271	19	low	low	JJ
cord-276456-oa6hh7ky	271	20	energy	energy	NN
cord-276456-oa6hh7ky	271	21	4-helical	4-helical	CD
cord-276456-oa6hh7ky	271	22	bundle	bundle	NN
cord-276456-oa6hh7ky	271	23	may	may	MD
cord-276456-oa6hh7ky	271	24	not	not	RB
cord-276456-oa6hh7ky	271	25	be	be	VB
cord-276456-oa6hh7ky	271	26	an	an	DT
cord-276456-oa6hh7ky	271	27	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	271	28	in	in	IN
cord-276456-oa6hh7ky	271	29	fusion	fusion	NN
cord-276456-oa6hh7ky	271	30	,	,	,
cord-276456-oa6hh7ky	271	31	but	but	CC
cord-276456-oa6hh7ky	271	32	rather	rather	RB
cord-276456-oa6hh7ky	271	33	either	either	CC
cord-276456-oa6hh7ky	271	34	a	a	DT
cord-276456-oa6hh7ky	271	35	dead	dead	JJ
cord-276456-oa6hh7ky	271	36	-	-	HYPH
cord-276456-oa6hh7ky	271	37	end	end	NN
cord-276456-oa6hh7ky	271	38	conformation	conformation	NN
cord-276456-oa6hh7ky	271	39	or	or	CC
cord-276456-oa6hh7ky	271	40	a	a	DT
cord-276456-oa6hh7ky	271	41	post	post	JJ
cord-276456-oa6hh7ky	271	42	-	-	JJ
cord-276456-oa6hh7ky	271	43	fusion	fusion	JJ
cord-276456-oa6hh7ky	271	44	conformation	conformation	NN
cord-276456-oa6hh7ky	271	45	.	.	.
cord-276456-oa6hh7ky	272	1	An	an	DT
cord-276456-oa6hh7ky	272	2	experiment	experiment	NN
cord-276456-oa6hh7ky	272	3	missing	miss	VBG
cord-276456-oa6hh7ky	272	4	from	from	IN
cord-276456-oa6hh7ky	272	5	the	the	DT
cord-276456-oa6hh7ky	272	6	field	field	NN
cord-276456-oa6hh7ky	272	7	is	be	VBZ
cord-276456-oa6hh7ky	272	8	a	a	DT
cord-276456-oa6hh7ky	272	9	demonstration	demonstration	NN
cord-276456-oa6hh7ky	272	10	of	of	IN
cord-276456-oa6hh7ky	272	11	helical	helical	JJ
cord-276456-oa6hh7ky	272	12	bundle	bundle	NN
cord-276456-oa6hh7ky	272	13	formation	formation	NN
cord-276456-oa6hh7ky	272	14	before	before	RB
cord-276456-oa6hh7ky	272	15	,	,	,
cord-276456-oa6hh7ky	272	16	or	or	CC
cord-276456-oa6hh7ky	272	17	simultaneous	simultaneous	JJ
cord-276456-oa6hh7ky	272	18	with	with	IN
cord-276456-oa6hh7ky	272	19	fusion	fusion	NN
cord-276456-oa6hh7ky	272	20	pore	pore	NN
cord-276456-oa6hh7ky	272	21	formation	formation	NN
cord-276456-oa6hh7ky	272	22	,	,	,
cord-276456-oa6hh7ky	272	23	as	as	IN
cord-276456-oa6hh7ky	272	24	described	describe	VBN
cord-276456-oa6hh7ky	272	25	above	above	RB
cord-276456-oa6hh7ky	272	26	for	for	IN
cord-276456-oa6hh7ky	272	27	viral	viral	JJ
cord-276456-oa6hh7ky	272	28	fusion	fusion	NN
cord-276456-oa6hh7ky	272	29	.	.	.
cord-276456-oa6hh7ky	273	1	There	there	EX
cord-276456-oa6hh7ky	273	2	is	be	VBZ
cord-276456-oa6hh7ky	273	3	strong	strong	JJ
cord-276456-oa6hh7ky	273	4	evidence	evidence	NN
cord-276456-oa6hh7ky	273	5	that	that	IN
cord-276456-oa6hh7ky	273	6	prior	prior	JJ
cord-276456-oa6hh7ky	273	7	interaction	interaction	NN
cord-276456-oa6hh7ky	273	8	between	between	IN
cord-276456-oa6hh7ky	273	9	the	the	DT
cord-276456-oa6hh7ky	273	10	plasma	plasma	NN
cord-276456-oa6hh7ky	273	11	membrane	membrane	NN
cord-276456-oa6hh7ky	273	12	SNAREs	SNAREs	NNP
cord-276456-oa6hh7ky	273	13	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	273	14	and	and	CC
cord-276456-oa6hh7ky	273	15	SNAP25	SNAP25	NNP
cord-276456-oa6hh7ky	273	16	increases	increase	VBZ
cord-276456-oa6hh7ky	273	17	rate	rate	NN
cord-276456-oa6hh7ky	273	18	of	of	IN
cord-276456-oa6hh7ky	273	19	interaction	interaction	NN
cord-276456-oa6hh7ky	273	20	with	with	IN
cord-276456-oa6hh7ky	273	21	VAMP	VAMP	NNP
cord-276456-oa6hh7ky	273	22	.	.	.
cord-276456-oa6hh7ky	274	1	83	83	CD
cord-276456-oa6hh7ky	275	1	The	the	DT
cord-276456-oa6hh7ky	275	2	relationship	relationship	NN
cord-276456-oa6hh7ky	275	3	of	of	IN
cord-276456-oa6hh7ky	275	4	the	the	DT
cord-276456-oa6hh7ky	275	5	post	post	JJ
cord-276456-oa6hh7ky	275	6	-	-	JJ
cord-276456-oa6hh7ky	275	7	fusion	fusion	JJ
cord-276456-oa6hh7ky	275	8	SNARE	snare	NN
cord-276456-oa6hh7ky	275	9	complex	complex	JJ
cord-276456-oa6hh7ky	275	10	(	(	-LRB-
cord-276456-oa6hh7ky	275	11	Figure	figure	NN
cord-276456-oa6hh7ky	275	12	11	11	CD
cord-276456-oa6hh7ky	275	13	)	)	-RRB-
cord-276456-oa6hh7ky	275	14	to	to	IN
cord-276456-oa6hh7ky	275	15	lipid	lipid	NN
cord-276456-oa6hh7ky	275	16	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	275	17	that	that	WDT
cord-276456-oa6hh7ky	275	18	occur	occur	VBP
cord-276456-oa6hh7ky	275	19	during	during	IN
cord-276456-oa6hh7ky	275	20	fusion	fusion	NN
cord-276456-oa6hh7ky	275	21	and	and	CC
cord-276456-oa6hh7ky	275	22	content	content	NN
cord-276456-oa6hh7ky	275	23	mixing	mixing	NN
cord-276456-oa6hh7ky	275	24	are	be	VBP
cord-276456-oa6hh7ky	275	25	currently	currently	RB
cord-276456-oa6hh7ky	275	26	not	not	RB
cord-276456-oa6hh7ky	275	27	known	know	VBN
cord-276456-oa6hh7ky	275	28	.	.	.
cord-276456-oa6hh7ky	276	1	One	one	CD
cord-276456-oa6hh7ky	276	2	study	study	NN
cord-276456-oa6hh7ky	276	3	has	have	VBZ
cord-276456-oa6hh7ky	276	4	placed	place	VBN
cord-276456-oa6hh7ky	276	5	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	276	6	as	as	IN
cord-276456-oa6hh7ky	276	7	a	a	DT
cord-276456-oa6hh7ky	276	8	pore	pore	NN
cord-276456-oa6hh7ky	276	9	-	-	HYPH
cord-276456-oa6hh7ky	276	10	forming	form	VBG
cord-276456-oa6hh7ky	276	11	molecule	molecule	NN
cord-276456-oa6hh7ky	276	12	with	with	IN
cord-276456-oa6hh7ky	276	13	5	5	CD
cord-276456-oa6hh7ky	276	14	-	-	SYM
cord-276456-oa6hh7ky	276	15	8	8	CD
cord-276456-oa6hh7ky	276	16	syntaxin	syntaxin	JJ
cord-276456-oa6hh7ky	276	17	molecules	molecule	NNS
cord-276456-oa6hh7ky	276	18	making	make	VBG
cord-276456-oa6hh7ky	276	19	up	up	RP
cord-276456-oa6hh7ky	276	20	a	a	DT
cord-276456-oa6hh7ky	276	21	fusion	fusion	NN
cord-276456-oa6hh7ky	276	22	pore	pore	NN
cord-276456-oa6hh7ky	276	23	.	.	.
cord-276456-oa6hh7ky	277	1	84	84	CD
cord-276456-oa6hh7ky	277	2	Assembly	Assembly	NNP
cord-276456-oa6hh7ky	277	3	of	of	IN
cord-276456-oa6hh7ky	277	4	5	5	CD
cord-276456-oa6hh7ky	277	5	-	-	SYM
cord-276456-oa6hh7ky	277	6	8	8	CD
cord-276456-oa6hh7ky	277	7	SNARE	snare	NN
cord-276456-oa6hh7ky	277	8	complexes	complex	NNS
cord-276456-oa6hh7ky	277	9	as	as	IN
cord-276456-oa6hh7ky	277	10	a	a	DT
cord-276456-oa6hh7ky	277	11	minimum	minimum	JJ
cord-276456-oa6hh7ky	277	12	number	number	NN
cord-276456-oa6hh7ky	277	13	required	require	VBN
cord-276456-oa6hh7ky	277	14	to	to	TO
cord-276456-oa6hh7ky	277	15	drive	drive	VB
cord-276456-oa6hh7ky	277	16	fusion	fusion	NN
cord-276456-oa6hh7ky	277	17	events	event	NNS
cord-276456-oa6hh7ky	277	18	is	be	VBZ
cord-276456-oa6hh7ky	277	19	in	in	IN
cord-276456-oa6hh7ky	277	20	good	good	JJ
cord-276456-oa6hh7ky	277	21	agreement	agreement	NN
cord-276456-oa6hh7ky	277	22	with	with	IN
cord-276456-oa6hh7ky	277	23	theoretical	theoretical	JJ
cord-276456-oa6hh7ky	277	24	considerations	consideration	NNS
cord-276456-oa6hh7ky	277	25	of	of	IN
cord-276456-oa6hh7ky	277	26	the	the	DT
cord-276456-oa6hh7ky	277	27	energetics	energetic	NNS
cord-276456-oa6hh7ky	277	28	of	of	IN
cord-276456-oa6hh7ky	277	29	SNARE	snare	VB
cord-276456-oa6hh7ky	277	30	complex	complex	JJ
cord-276456-oa6hh7ky	277	31	assembly	assembly	NN
cord-276456-oa6hh7ky	277	32	and	and	CC
cord-276456-oa6hh7ky	277	33	membrane	membrane	NN
cord-276456-oa6hh7ky	277	34	fusion	fusion	NN
cord-276456-oa6hh7ky	277	35	.	.	.
cord-276456-oa6hh7ky	278	1	B8	B8	NNP
cord-276456-oa6hh7ky	278	2	SNARE	snare	NN
cord-276456-oa6hh7ky	278	3	complexes	complex	NNS
cord-276456-oa6hh7ky	278	4	were	be	VBD
cord-276456-oa6hh7ky	278	5	required	require	VBN
cord-276456-oa6hh7ky	278	6	to	to	TO
cord-276456-oa6hh7ky	278	7	promote	promote	VB
cord-276456-oa6hh7ky	278	8	fast	fast	JJ
cord-276456-oa6hh7ky	278	9	fusion	fusion	NN
cord-276456-oa6hh7ky	278	10	in	in	IN
cord-276456-oa6hh7ky	278	11	supported	support	VBN
cord-276456-oa6hh7ky	278	12	bilayer	bilayer	NN
cord-276456-oa6hh7ky	278	13	experiments	experiment	NNS
cord-276456-oa6hh7ky	278	14	,	,	,
cord-276456-oa6hh7ky	278	15	85	85	CD
cord-276456-oa6hh7ky	278	16	and	and	CC
cord-276456-oa6hh7ky	278	17	fewer	few	JJR
cord-276456-oa6hh7ky	278	18	in	in	IN
cord-276456-oa6hh7ky	278	19	other	other	JJ
cord-276456-oa6hh7ky	278	20	lipid	lipid	NN
cord-276456-oa6hh7ky	278	21	mixtures	mixture	NNS
cord-276456-oa6hh7ky	278	22	including	include	VBG
cord-276456-oa6hh7ky	278	23	PE	PE	NNP
cord-276456-oa6hh7ky	278	24	,	,	,
cord-276456-oa6hh7ky	278	25	presumably	presumably	RB
cord-276456-oa6hh7ky	278	26	because	because	IN
cord-276456-oa6hh7ky	278	27	PE	PE	NNP
cord-276456-oa6hh7ky	278	28	promotes	promote	VBZ
cord-276456-oa6hh7ky	278	29	fusion	fusion	NN
cord-276456-oa6hh7ky	278	30	by	by	IN
cord-276456-oa6hh7ky	278	31	curvature	curvature	NN
cord-276456-oa6hh7ky	278	32	.	.	.
cord-276456-oa6hh7ky	279	1	86	86	CD
cord-276456-oa6hh7ky	280	1	What	what	WP
cord-276456-oa6hh7ky	280	2	is	be	VBZ
cord-276456-oa6hh7ky	280	3	enormously	enormously	RB
cord-276456-oa6hh7ky	280	4	fascinating	fascinating	JJ
cord-276456-oa6hh7ky	280	5	is	be	VBZ
cord-276456-oa6hh7ky	280	6	how	how	WRB
cord-276456-oa6hh7ky	280	7	the	the	DT
cord-276456-oa6hh7ky	280	8	protein	protein	NN
cord-276456-oa6hh7ky	280	9	fusogens	fusogens	NNP
cord-276456-oa6hh7ky	280	10	form	form	NN
cord-276456-oa6hh7ky	280	11	such	such	PDT
cord-276456-oa6hh7ky	280	12	a	a	DT
cord-276456-oa6hh7ky	280	13	pore	pore	NN
cord-276456-oa6hh7ky	280	14	,	,	,
cord-276456-oa6hh7ky	280	15	how	how	WRB
cord-276456-oa6hh7ky	280	16	the	the	DT
cord-276456-oa6hh7ky	280	17	pore	pore	NN
cord-276456-oa6hh7ky	280	18	forms	form	NNS
cord-276456-oa6hh7ky	280	19	initially	initially	RB
cord-276456-oa6hh7ky	280	20	and	and	CC
cord-276456-oa6hh7ky	280	21	how	how	WRB
cord-276456-oa6hh7ky	280	22	the	the	DT
cord-276456-oa6hh7ky	280	23	pore	pore	NN
cord-276456-oa6hh7ky	280	24	dilates	dilate	VBZ
cord-276456-oa6hh7ky	280	25	as	as	IN
cord-276456-oa6hh7ky	280	26	fusion	fusion	NN
cord-276456-oa6hh7ky	280	27	proceeds	proceed	NNS
cord-276456-oa6hh7ky	280	28	to	to	IN
cord-276456-oa6hh7ky	280	29	completion	completion	NN
cord-276456-oa6hh7ky	280	30	.	.	.
cord-276456-oa6hh7ky	281	1	These	these	DT
cord-276456-oa6hh7ky	281	2	pathways	pathway	NNS
cord-276456-oa6hh7ky	281	3	may	may	MD
cord-276456-oa6hh7ky	281	4	have	have	VB
cord-276456-oa6hh7ky	281	5	different	different	JJ
cord-276456-oa6hh7ky	281	6	kinetic	kinetic	JJ
cord-276456-oa6hh7ky	281	7	and	and	CC
cord-276456-oa6hh7ky	281	8	thermodynamic	thermodynamic	JJ
cord-276456-oa6hh7ky	281	9	parameters	parameter	NNS
cord-276456-oa6hh7ky	281	10	for	for	IN
cord-276456-oa6hh7ky	281	11	different	different	JJ
cord-276456-oa6hh7ky	281	12	types	type	NNS
cord-276456-oa6hh7ky	281	13	of	of	IN
cord-276456-oa6hh7ky	281	14	biological	biological	JJ
cord-276456-oa6hh7ky	281	15	fusion	fusion	NN
cord-276456-oa6hh7ky	281	16	,	,	,
cord-276456-oa6hh7ky	281	17	depending	depend	VBG
cord-276456-oa6hh7ky	281	18	on	on	IN
cord-276456-oa6hh7ky	281	19	the	the	DT
cord-276456-oa6hh7ky	281	20	physiological	physiological	JJ
cord-276456-oa6hh7ky	281	21	requirements	requirement	NNS
cord-276456-oa6hh7ky	281	22	of	of	IN
cord-276456-oa6hh7ky	281	23	the	the	DT
cord-276456-oa6hh7ky	281	24	particular	particular	JJ
cord-276456-oa6hh7ky	281	25	fusion	fusion	NN
cord-276456-oa6hh7ky	281	26	event	event	NN
cord-276456-oa6hh7ky	281	27	.	.	.
cord-276456-oa6hh7ky	282	1	The	the	DT
cord-276456-oa6hh7ky	282	2	SNARE	snare	NN
cord-276456-oa6hh7ky	282	3	machinery	machinery	NN
cord-276456-oa6hh7ky	282	4	certainly	certainly	RB
cord-276456-oa6hh7ky	282	5	appears	appear	VBZ
cord-276456-oa6hh7ky	282	6	to	to	TO
cord-276456-oa6hh7ky	282	7	have	have	VB
cord-276456-oa6hh7ky	282	8	the	the	DT
cord-276456-oa6hh7ky	282	9	potential	potential	NN
cord-276456-oa6hh7ky	282	10	for	for	IN
cord-276456-oa6hh7ky	282	11	adaptability	adaptability	NN
cord-276456-oa6hh7ky	282	12	,	,	,
cord-276456-oa6hh7ky	282	13	mediating	mediate	VBG
cord-276456-oa6hh7ky	282	14	types	type	NNS
cord-276456-oa6hh7ky	282	15	of	of	IN
cord-276456-oa6hh7ky	282	16	fusion	fusion	NN
cord-276456-oa6hh7ky	282	17	as	as	RB
cord-276456-oa6hh7ky	282	18	diverse	diverse	JJ
cord-276456-oa6hh7ky	282	19	as	as	IN
cord-276456-oa6hh7ky	282	20	'	'	``
cord-276456-oa6hh7ky	282	21	'	'	''
cord-276456-oa6hh7ky	282	22	kiss	kiss	VB
cord-276456-oa6hh7ky	282	23	and	and	CC
cord-276456-oa6hh7ky	282	24	run	run	VB
cord-276456-oa6hh7ky	282	25	'	'	''
cord-276456-oa6hh7ky	282	26	'	'	''
cord-276456-oa6hh7ky	282	27	,	,	,
cord-276456-oa6hh7ky	282	28	complete	complete	JJ
cord-276456-oa6hh7ky	282	29	fusion	fusion	NN
cord-276456-oa6hh7ky	282	30	during	during	IN
cord-276456-oa6hh7ky	282	31	constitutive	constitutive	JJ
cord-276456-oa6hh7ky	282	32	events	event	NNS
cord-276456-oa6hh7ky	282	33	of	of	IN
cord-276456-oa6hh7ky	282	34	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	282	35	and	and	CC
cord-276456-oa6hh7ky	282	36	homotypic	homotypic	JJ
cord-276456-oa6hh7ky	282	37	fusion	fusion	NN
cord-276456-oa6hh7ky	282	38	events	event	NNS
cord-276456-oa6hh7ky	282	39	such	such	JJ
cord-276456-oa6hh7ky	282	40	as	as	IN
cord-276456-oa6hh7ky	282	41	those	those	DT
cord-276456-oa6hh7ky	282	42	between	between	IN
cord-276456-oa6hh7ky	282	43	endosomes	endosome	NNS
cord-276456-oa6hh7ky	282	44	.	.	.
cord-276456-oa6hh7ky	283	1	87	87	CD
cord-276456-oa6hh7ky	284	1	The	the	DT
cord-276456-oa6hh7ky	284	2	SNARE	snare	NN
cord-276456-oa6hh7ky	284	3	complexes	complex	NNS
cord-276456-oa6hh7ky	284	4	for	for	IN
cord-276456-oa6hh7ky	284	5	which	which	WDT
cord-276456-oa6hh7ky	284	6	the	the	DT
cord-276456-oa6hh7ky	284	7	structures	structure	NNS
cord-276456-oa6hh7ky	284	8	have	have	VBP
cord-276456-oa6hh7ky	284	9	been	be	VBN
cord-276456-oa6hh7ky	284	10	solved	solve	VBN
cord-276456-oa6hh7ky	284	11	all	all	DT
cord-276456-oa6hh7ky	284	12	contain	contain	VBP
cord-276456-oa6hh7ky	284	13	the	the	DT
cord-276456-oa6hh7ky	284	14	four	four	CD
cord-276456-oa6hh7ky	284	15	helix	helix	NN
cord-276456-oa6hh7ky	284	16	bundle	bundle	NN
cord-276456-oa6hh7ky	284	17	in	in	IN
cord-276456-oa6hh7ky	284	18	a	a	DT
cord-276456-oa6hh7ky	284	19	parallel	parallel	JJ
cord-276456-oa6hh7ky	284	20	orientation	orientation	NN
cord-276456-oa6hh7ky	284	21	.	.	.
cord-276456-oa6hh7ky	285	1	Perhaps	perhaps	RB
cord-276456-oa6hh7ky	285	2	not	not	RB
cord-276456-oa6hh7ky	285	3	surprisingly	surprisingly	RB
cord-276456-oa6hh7ky	285	4	,	,	,
cord-276456-oa6hh7ky	285	5	given	give	VBN
cord-276456-oa6hh7ky	285	6	the	the	DT
cord-276456-oa6hh7ky	285	7	versatility	versatility	NN
cord-276456-oa6hh7ky	285	8	of	of	IN
cord-276456-oa6hh7ky	285	9	coiledcoil	coiledcoil	NNP
cord-276456-oa6hh7ky	285	10	structures	structure	NNS
cord-276456-oa6hh7ky	285	11	,	,	,
cord-276456-oa6hh7ky	285	12	the	the	DT
cord-276456-oa6hh7ky	285	13	SNARE	snare	NN
cord-276456-oa6hh7ky	285	14	domains	domain	NNS
cord-276456-oa6hh7ky	285	15	are	be	VBP
cord-276456-oa6hh7ky	285	16	also	also	RB
cord-276456-oa6hh7ky	285	17	capable	capable	JJ
cord-276456-oa6hh7ky	285	18	of	of	IN
cord-276456-oa6hh7ky	285	19	associating	associate	VBG
cord-276456-oa6hh7ky	285	20	in	in	IN
cord-276456-oa6hh7ky	285	21	anti	anti	JJ
cord-276456-oa6hh7ky	285	22	-	-	JJ
cord-276456-oa6hh7ky	285	23	parallel	parallel	JJ
cord-276456-oa6hh7ky	285	24	bundles	bundle	NNS
cord-276456-oa6hh7ky	285	25	,	,	,
cord-276456-oa6hh7ky	285	26	which	which	WDT
cord-276456-oa6hh7ky	285	27	are	be	VBP
cord-276456-oa6hh7ky	285	28	also	also	RB
cord-276456-oa6hh7ky	285	29	stable	stable	JJ
cord-276456-oa6hh7ky	285	30	,	,	,
cord-276456-oa6hh7ky	285	31	although	although	IN
cord-276456-oa6hh7ky	285	32	not	not	RB
cord-276456-oa6hh7ky	285	33	as	as	RB
cord-276456-oa6hh7ky	285	34	stable	stable	JJ
cord-276456-oa6hh7ky	285	35	as	as	IN
cord-276456-oa6hh7ky	285	36	the	the	DT
cord-276456-oa6hh7ky	285	37	parallel	parallel	JJ
cord-276456-oa6hh7ky	285	38	bundles	bundle	NNS
cord-276456-oa6hh7ky	285	39	.	.	.
cord-276456-oa6hh7ky	286	1	88	88	CD
cord-276456-oa6hh7ky	287	1	This	this	DT
cord-276456-oa6hh7ky	287	2	is	be	VBZ
cord-276456-oa6hh7ky	287	3	superficially	superficially	RB
cord-276456-oa6hh7ky	287	4	reminiscent	reminiscent	JJ
cord-276456-oa6hh7ky	287	5	of	of	IN
cord-276456-oa6hh7ky	287	6	the	the	DT
cord-276456-oa6hh7ky	287	7	anti	anti	JJ
cord-276456-oa6hh7ky	287	8	-	-	JJ
cord-276456-oa6hh7ky	287	9	parallel	parallel	JJ
cord-276456-oa6hh7ky	287	10	and	and	CC
cord-276456-oa6hh7ky	287	11	parallel	parallel	JJ
cord-276456-oa6hh7ky	287	12	coiled	coil	VBN
cord-276456-oa6hh7ky	287	13	-	-	HYPH
cord-276456-oa6hh7ky	287	14	coil	coil	NN
cord-276456-oa6hh7ky	287	15	transitions	transition	NNS
cord-276456-oa6hh7ky	287	16	experienced	experience	VBN
cord-276456-oa6hh7ky	287	17	by	by	IN
cord-276456-oa6hh7ky	287	18	different	different	JJ
cord-276456-oa6hh7ky	287	19	conformations	conformation	NNS
cord-276456-oa6hh7ky	287	20	of	of	IN
cord-276456-oa6hh7ky	287	21	HA	HA	NNP
cord-276456-oa6hh7ky	287	22	(	(	-LRB-
cord-276456-oa6hh7ky	287	23	Figures	figure	NNS
cord-276456-oa6hh7ky	287	24	4	4	CD
cord-276456-oa6hh7ky	287	25	and	and	CC
cord-276456-oa6hh7ky	287	26	5	5	CD
cord-276456-oa6hh7ky	287	27	)	)	-RRB-
cord-276456-oa6hh7ky	287	28	although	although	IN
cord-276456-oa6hh7ky	287	29	caution	caution	NN
cord-276456-oa6hh7ky	287	30	should	should	MD
cord-276456-oa6hh7ky	287	31	be	be	VB
cord-276456-oa6hh7ky	287	32	exercised	exercise	VBN
cord-276456-oa6hh7ky	287	33	in	in	IN
cord-276456-oa6hh7ky	287	34	extending	extend	VBG
cord-276456-oa6hh7ky	287	35	these	these	DT
cord-276456-oa6hh7ky	287	36	analogies	analogy	NNS
cord-276456-oa6hh7ky	287	37	given	give	VBN
cord-276456-oa6hh7ky	287	38	the	the	DT
cord-276456-oa6hh7ky	287	39	topological	topological	JJ
cord-276456-oa6hh7ky	287	40	constraints	constraint	NNS
cord-276456-oa6hh7ky	287	41	of	of	IN
cord-276456-oa6hh7ky	287	42	the	the	DT
cord-276456-oa6hh7ky	287	43	fusion	fusion	NN
cord-276456-oa6hh7ky	287	44	machinery	machinery	NN
cord-276456-oa6hh7ky	287	45	.	.	.
cord-276456-oa6hh7ky	288	1	It	-PRON-	PRP
cord-276456-oa6hh7ky	288	2	is	be	VBZ
cord-276456-oa6hh7ky	288	3	not	not	RB
cord-276456-oa6hh7ky	288	4	known	know	VBN
cord-276456-oa6hh7ky	288	5	what	what	WP
cord-276456-oa6hh7ky	288	6	such	such	JJ
cord-276456-oa6hh7ky	288	7	associations	association	NNS
cord-276456-oa6hh7ky	288	8	may	may	MD
cord-276456-oa6hh7ky	288	9	represent	represent	VB
cord-276456-oa6hh7ky	288	10	physiologically	physiologically	RB
cord-276456-oa6hh7ky	288	11	;	;	:
cord-276456-oa6hh7ky	288	12	they	-PRON-	PRP
cord-276456-oa6hh7ky	288	13	could	could	MD
cord-276456-oa6hh7ky	288	14	possibly	possibly	RB
cord-276456-oa6hh7ky	288	15	represent	represent	VB
cord-276456-oa6hh7ky	288	16	a	a	DT
cord-276456-oa6hh7ky	288	17	means	means	NN
cord-276456-oa6hh7ky	288	18	of	of	IN
cord-276456-oa6hh7ky	288	19	tethering	tether	VBG
cord-276456-oa6hh7ky	288	20	membranes	membrane	NNS
cord-276456-oa6hh7ky	288	21	independently	independently	RB
cord-276456-oa6hh7ky	288	22	of	of	IN
cord-276456-oa6hh7ky	288	23	fusion	fusion	NN
cord-276456-oa6hh7ky	288	24	,	,	,
cord-276456-oa6hh7ky	288	25	or	or	CC
cord-276456-oa6hh7ky	288	26	may	may	MD
cord-276456-oa6hh7ky	288	27	be	be	VB
cord-276456-oa6hh7ky	288	28	unproductive	unproductive	JJ
cord-276456-oa6hh7ky	288	29	molecules	molecule	NNS
cord-276456-oa6hh7ky	288	30	requiring	require	VBG
cord-276456-oa6hh7ky	288	31	reconditioning	reconditioning	NN
cord-276456-oa6hh7ky	288	32	by	by	IN
cord-276456-oa6hh7ky	288	33	accessory	accessory	NN
cord-276456-oa6hh7ky	288	34	factors	factor	NNS
cord-276456-oa6hh7ky	288	35	in	in	IN
cord-276456-oa6hh7ky	288	36	order	order	NN
cord-276456-oa6hh7ky	288	37	to	to	TO
cord-276456-oa6hh7ky	288	38	participate	participate	VB
cord-276456-oa6hh7ky	288	39	in	in	IN
cord-276456-oa6hh7ky	288	40	multiple	multiple	JJ
cord-276456-oa6hh7ky	288	41	rounds	round	NNS
cord-276456-oa6hh7ky	288	42	of	of	IN
cord-276456-oa6hh7ky	288	43	membrane	membrane	NN
cord-276456-oa6hh7ky	288	44	fusion	fusion	NN
cord-276456-oa6hh7ky	288	45	.	.	.
cord-276456-oa6hh7ky	289	1	The	the	DT
cord-276456-oa6hh7ky	289	2	profile	profile	NN
cord-276456-oa6hh7ky	289	3	of	of	IN
cord-276456-oa6hh7ky	289	4	the	the	DT
cord-276456-oa6hh7ky	289	5	energy	energy	NN
cord-276456-oa6hh7ky	289	6	landscape	landscape	NN
cord-276456-oa6hh7ky	289	7	89	89	CD
cord-276456-oa6hh7ky	289	8	traversed	traverse	VBN
cord-276456-oa6hh7ky	289	9	by	by	IN
cord-276456-oa6hh7ky	289	10	the	the	DT
cord-276456-oa6hh7ky	289	11	fusion	fusion	NN
cord-276456-oa6hh7ky	289	12	reaction	reaction	NN
cord-276456-oa6hh7ky	289	13	will	will	MD
cord-276456-oa6hh7ky	289	14	be	be	VB
cord-276456-oa6hh7ky	289	15	influenced	influence	VBN
cord-276456-oa6hh7ky	289	16	by	by	IN
cord-276456-oa6hh7ky	289	17	a	a	DT
cord-276456-oa6hh7ky	289	18	multitude	multitude	NN
cord-276456-oa6hh7ky	289	19	of	of	IN
cord-276456-oa6hh7ky	289	20	exogenous	exogenous	JJ
cord-276456-oa6hh7ky	289	21	factors	factor	NNS
cord-276456-oa6hh7ky	289	22	.	.	.
cord-276456-oa6hh7ky	290	1	Known	know	VBN
cord-276456-oa6hh7ky	290	2	factors	factor	NNS
cord-276456-oa6hh7ky	290	3	include	include	VBP
cord-276456-oa6hh7ky	290	4	the	the	DT
cord-276456-oa6hh7ky	290	5	membrane	membrane	NN
cord-276456-oa6hh7ky	290	6	lipid	lipid	NN
cord-276456-oa6hh7ky	290	7	composition	composition	NN
cord-276456-oa6hh7ky	290	8	,	,	,
cord-276456-oa6hh7ky	290	9	the	the	DT
cord-276456-oa6hh7ky	290	10	availability	availability	NN
cord-276456-oa6hh7ky	290	11	of	of	IN
cord-276456-oa6hh7ky	290	12	SNARE	snare	NN
cord-276456-oa6hh7ky	290	13	proteins	protein	NNS
cord-276456-oa6hh7ky	290	14	in	in	IN
cord-276456-oa6hh7ky	290	15	suitable	suitable	JJ
cord-276456-oa6hh7ky	290	16	pre	pre	JJ
cord-276456-oa6hh7ky	290	17	-	-	JJ
cord-276456-oa6hh7ky	290	18	fusion	fusion	JJ
cord-276456-oa6hh7ky	290	19	states	state	NNS
cord-276456-oa6hh7ky	290	20	and	and	CC
cord-276456-oa6hh7ky	290	21	the	the	DT
cord-276456-oa6hh7ky	290	22	specific	specific	JJ
cord-276456-oa6hh7ky	290	23	activity	activity	NN
cord-276456-oa6hh7ky	290	24	of	of	IN
cord-276456-oa6hh7ky	290	25	SNARE	snare	VB
cord-276456-oa6hh7ky	290	26	accessory	accessory	NN
cord-276456-oa6hh7ky	290	27	factors	factor	NNS
cord-276456-oa6hh7ky	290	28	(	(	-LRB-
cord-276456-oa6hh7ky	290	29	Table	table	NN
cord-276456-oa6hh7ky	290	30	1	1	CD
cord-276456-oa6hh7ky	290	31	)	)	-RRB-
cord-276456-oa6hh7ky	290	32	.	.	.
cord-276456-oa6hh7ky	291	1	These	these	DT
cord-276456-oa6hh7ky	291	2	factors	factor	NNS
cord-276456-oa6hh7ky	291	3	can	can	MD
cord-276456-oa6hh7ky	291	4	have	have	VB
cord-276456-oa6hh7ky	291	5	multiple	multiple	JJ
cord-276456-oa6hh7ky	291	6	influences	influence	NNS
cord-276456-oa6hh7ky	291	7	,	,	,
cord-276456-oa6hh7ky	291	8	for	for	IN
cord-276456-oa6hh7ky	291	9	example	example	NN
cord-276456-oa6hh7ky	291	10	,	,	,
cord-276456-oa6hh7ky	291	11	membrane	membrane	NN
cord-276456-oa6hh7ky	291	12	composition	composition	NN
cord-276456-oa6hh7ky	291	13	can	can	MD
cord-276456-oa6hh7ky	291	14	play	play	VB
cord-276456-oa6hh7ky	291	15	a	a	DT
cord-276456-oa6hh7ky	291	16	role	role	NN
cord-276456-oa6hh7ky	291	17	in	in	IN
cord-276456-oa6hh7ky	291	18	providing	provide	VBG
cord-276456-oa6hh7ky	291	19	molecular	molecular	JJ
cord-276456-oa6hh7ky	291	20	determinants	determinant	NNS
cord-276456-oa6hh7ky	291	21	for	for	IN
cord-276456-oa6hh7ky	291	22	protein	protein	NN
cord-276456-oa6hh7ky	291	23	assembly	assembly	NN
cord-276456-oa6hh7ky	291	24	and	and	CC
cord-276456-oa6hh7ky	291	25	will	will	MD
cord-276456-oa6hh7ky	291	26	also	also	RB
cord-276456-oa6hh7ky	291	27	determine	determine	VB
cord-276456-oa6hh7ky	291	28	membrane	membrane	NN
cord-276456-oa6hh7ky	291	29	elasticity	elasticity	NN
cord-276456-oa6hh7ky	291	30	.	.	.
cord-276456-oa6hh7ky	292	1	How	how	WRB
cord-276456-oa6hh7ky	292	2	conformational	conformational	JJ
cord-276456-oa6hh7ky	292	3	changes	change	NNS
cord-276456-oa6hh7ky	292	4	amongst	amongst	IN
cord-276456-oa6hh7ky	292	5	SNARE	snare	NN
cord-276456-oa6hh7ky	292	6	proteins	protein	NNS
cord-276456-oa6hh7ky	292	7	and	and	CC
cord-276456-oa6hh7ky	292	8	their	-PRON-	PRP$
cord-276456-oa6hh7ky	292	9	accessory	accessory	NN
cord-276456-oa6hh7ky	292	10	factors	factor	NNS
cord-276456-oa6hh7ky	292	11	control	control	VBP
cord-276456-oa6hh7ky	292	12	the	the	DT
cord-276456-oa6hh7ky	292	13	thermodynamics	thermodynamic	NNS
cord-276456-oa6hh7ky	292	14	and	and	CC
cord-276456-oa6hh7ky	292	15	kinetics	kinetic	NNS
cord-276456-oa6hh7ky	292	16	of	of	IN
cord-276456-oa6hh7ky	292	17	docking	docking	NN
cord-276456-oa6hh7ky	292	18	,	,	,
cord-276456-oa6hh7ky	292	19	lipid	lipid	NN
cord-276456-oa6hh7ky	292	20	mixing	mixing	NN
cord-276456-oa6hh7ky	292	21	and	and	CC
cord-276456-oa6hh7ky	292	22	content	content	NN
cord-276456-oa6hh7ky	292	23	mixing	mix	VBG
cord-276456-oa6hh7ky	292	24	after	after	IN
cord-276456-oa6hh7ky	292	25	membrane	membrane	NN
cord-276456-oa6hh7ky	292	26	fusion	fusion	NN
cord-276456-oa6hh7ky	292	27	remain	remain	VBP
cord-276456-oa6hh7ky	292	28	open	open	JJ
cord-276456-oa6hh7ky	292	29	questions	question	NNS
cord-276456-oa6hh7ky	292	30	.	.	.
cord-276456-oa6hh7ky	293	1	Our	-PRON-	PRP$
cord-276456-oa6hh7ky	293	2	understanding	understanding	NN
cord-276456-oa6hh7ky	293	3	of	of	IN
cord-276456-oa6hh7ky	293	4	the	the	DT
cord-276456-oa6hh7ky	293	5	conformational	conformational	JJ
cord-276456-oa6hh7ky	293	6	plasticity	plasticity	NN
cord-276456-oa6hh7ky	293	7	of	of	IN
cord-276456-oa6hh7ky	293	8	protein	protein	NN
cord-276456-oa6hh7ky	293	9	machineries	machinery	NNS
cord-276456-oa6hh7ky	293	10	and	and	CC
cord-276456-oa6hh7ky	293	11	the	the	DT
cord-276456-oa6hh7ky	293	12	hysteresis	hysteresis	NN
cord-276456-oa6hh7ky	293	13	properties	property	NNS
cord-276456-oa6hh7ky	293	14	of	of	IN
cord-276456-oa6hh7ky	293	15	biological	biological	JJ
cord-276456-oa6hh7ky	293	16	fusion	fusion	NN
cord-276456-oa6hh7ky	293	17	machines	machine	NNS
cord-276456-oa6hh7ky	293	18	lead	lead	VBP
cord-276456-oa6hh7ky	293	19	to	to	IN
cord-276456-oa6hh7ky	293	20	an	an	DT
cord-276456-oa6hh7ky	293	21	appreciation	appreciation	NN
cord-276456-oa6hh7ky	293	22	for	for	IN
cord-276456-oa6hh7ky	293	23	the	the	DT
cord-276456-oa6hh7ky	293	24	energetic	energetic	JJ
cord-276456-oa6hh7ky	293	25	complexities	complexity	NNS
cord-276456-oa6hh7ky	293	26	of	of	IN
cord-276456-oa6hh7ky	293	27	the	the	DT
cord-276456-oa6hh7ky	293	28	fusion	fusion	NN
cord-276456-oa6hh7ky	293	29	reaction	reaction	NN
cord-276456-oa6hh7ky	293	30	.	.	.
cord-276456-oa6hh7ky	294	1	The	the	DT
cord-276456-oa6hh7ky	294	2	use	use	NN
cord-276456-oa6hh7ky	294	3	of	of	IN
cord-276456-oa6hh7ky	294	4	single	single	JJ
cord-276456-oa6hh7ky	294	5	molecule	molecule	NN
cord-276456-oa6hh7ky	294	6	studies	study	NNS
cord-276456-oa6hh7ky	294	7	to	to	TO
cord-276456-oa6hh7ky	294	8	unravel	unravel	VB
cord-276456-oa6hh7ky	294	9	the	the	DT
cord-276456-oa6hh7ky	294	10	complex	complex	JJ
cord-276456-oa6hh7ky	294	11	energy	energy	NN
cord-276456-oa6hh7ky	294	12	landscape	landscape	NN
cord-276456-oa6hh7ky	294	13	of	of	IN
cord-276456-oa6hh7ky	294	14	membrane	membrane	NN
cord-276456-oa6hh7ky	294	15	fusion	fusion	NN
cord-276456-oa6hh7ky	294	16	will	will	MD
cord-276456-oa6hh7ky	294	17	be	be	VB
cord-276456-oa6hh7ky	294	18	an	an	DT
cord-276456-oa6hh7ky	294	19	important	important	JJ
cord-276456-oa6hh7ky	294	20	biophysical	biophysical	JJ
cord-276456-oa6hh7ky	294	21	approach	approach	NN
cord-276456-oa6hh7ky	294	22	with	with	IN
cord-276456-oa6hh7ky	294	23	tremendous	tremendous	JJ
cord-276456-oa6hh7ky	294	24	potential	potential	NN
cord-276456-oa6hh7ky	294	25	to	to	TO
cord-276456-oa6hh7ky	294	26	relate	relate	VB
cord-276456-oa6hh7ky	294	27	the	the	DT
cord-276456-oa6hh7ky	294	28	topography	topography	NN
cord-276456-oa6hh7ky	294	29	of	of	IN
cord-276456-oa6hh7ky	294	30	the	the	DT
cord-276456-oa6hh7ky	294	31	energy	energy	NN
cord-276456-oa6hh7ky	294	32	landscape	landscape	NN
cord-276456-oa6hh7ky	294	33	to	to	IN
cord-276456-oa6hh7ky	294	34	the	the	DT
cord-276456-oa6hh7ky	294	35	mechanism	mechanism	NN
cord-276456-oa6hh7ky	294	36	and	and	CC
cord-276456-oa6hh7ky	294	37	regulation	regulation	NN
cord-276456-oa6hh7ky	294	38	of	of	IN
cord-276456-oa6hh7ky	294	39	fusion	fusion	NN
cord-276456-oa6hh7ky	294	40	.	.	.
cord-276456-oa6hh7ky	295	1	Although	although	IN
cord-276456-oa6hh7ky	295	2	the	the	DT
cord-276456-oa6hh7ky	295	3	application	application	NN
cord-276456-oa6hh7ky	295	4	of	of	IN
cord-276456-oa6hh7ky	295	5	this	this	DT
cord-276456-oa6hh7ky	295	6	approach	approach	NN
cord-276456-oa6hh7ky	295	7	to	to	IN
cord-276456-oa6hh7ky	295	8	studying	study	VBG
cord-276456-oa6hh7ky	295	9	biological	biological	JJ
cord-276456-oa6hh7ky	295	10	fusion	fusion	NN
cord-276456-oa6hh7ky	295	11	machines	machine	NNS
cord-276456-oa6hh7ky	295	12	is	be	VBZ
cord-276456-oa6hh7ky	295	13	relatively	relatively	RB
cord-276456-oa6hh7ky	295	14	new	new	JJ
cord-276456-oa6hh7ky	295	15	,	,	,
cord-276456-oa6hh7ky	295	16	72	72	CD
cord-276456-oa6hh7ky	295	17	,	,	,
cord-276456-oa6hh7ky	295	18	[	[	-LRB-
cord-276456-oa6hh7ky	295	19	125	125	CD
cord-276456-oa6hh7ky	295	20	]	]	-RRB-
cord-276456-oa6hh7ky	295	21	[	[	-LRB-
cord-276456-oa6hh7ky	295	22	126	126	CD
cord-276456-oa6hh7ky	295	23	]	]	-RRB-
cord-276456-oa6hh7ky	295	24	[	[	-LRB-
cord-276456-oa6hh7ky	295	25	127	127	CD
cord-276456-oa6hh7ky	295	26	]	]	-RRB-
cord-276456-oa6hh7ky	295	27	[	[	-LRB-
cord-276456-oa6hh7ky	295	28	128	128	CD
cord-276456-oa6hh7ky	295	29	]	]	-RRB-
cord-276456-oa6hh7ky	295	30	[	[	-LRB-
cord-276456-oa6hh7ky	295	31	129	129	CD
cord-276456-oa6hh7ky	295	32	]	]	-RRB-
cord-276456-oa6hh7ky	295	33	[	[	-LRB-
cord-276456-oa6hh7ky	295	34	130	130	CD
cord-276456-oa6hh7ky	295	35	]	]	-RRB-
cord-276456-oa6hh7ky	296	1	such	such	JJ
cord-276456-oa6hh7ky	296	2	experiments	experiment	NNS
cord-276456-oa6hh7ky	296	3	have	have	VBP
cord-276456-oa6hh7ky	296	4	some	some	DT
cord-276456-oa6hh7ky	296	5	additional	additional	JJ
cord-276456-oa6hh7ky	296	6	advantages	advantage	NNS
cord-276456-oa6hh7ky	296	7	-such	-such	:
cord-276456-oa6hh7ky	296	8	as	as	IN
cord-276456-oa6hh7ky	296	9	being	be	VBG
cord-276456-oa6hh7ky	296	10	able	able	JJ
cord-276456-oa6hh7ky	296	11	to	to	TO
cord-276456-oa6hh7ky	296	12	distinguish	distinguish	VB
cord-276456-oa6hh7ky	296	13	fusion	fusion	NN
cord-276456-oa6hh7ky	296	14	events	event	NNS
cord-276456-oa6hh7ky	296	15	from	from	IN
cord-276456-oa6hh7ky	296	16	vesicle	vesicle	NN
cord-276456-oa6hh7ky	296	17	aggregation	aggregation	NN
cord-276456-oa6hh7ky	296	18	or	or	CC
cord-276456-oa6hh7ky	296	19	vesicle	vesicle	NN
cord-276456-oa6hh7ky	296	20	rupture	rupture	NN
cord-276456-oa6hh7ky	296	21	.	.	.
cord-276456-oa6hh7ky	297	1	Single	single	JJ
cord-276456-oa6hh7ky	297	2	molecule	molecule	NN
cord-276456-oa6hh7ky	297	3	approaches	approach	NNS
cord-276456-oa6hh7ky	297	4	of	of	IN
cord-276456-oa6hh7ky	297	5	fluorescently	fluorescently	RB
cord-276456-oa6hh7ky	297	6	-	-	HYPH
cord-276456-oa6hh7ky	297	7	labeled	label	VBN
cord-276456-oa6hh7ky	297	8	virus	virus	NN
cord-276456-oa6hh7ky	297	9	in	in	IN
cord-276456-oa6hh7ky	297	10	living	living	NN
cord-276456-oa6hh7ky	297	11	cells	cell	NNS
cord-276456-oa6hh7ky	297	12	has	have	VBZ
cord-276456-oa6hh7ky	297	13	allowed	allow	VBN
cord-276456-oa6hh7ky	297	14	visualization	visualization	NN
cord-276456-oa6hh7ky	297	15	of	of	IN
cord-276456-oa6hh7ky	297	16	influenza	influenza	NN
cord-276456-oa6hh7ky	297	17	fusion	fusion	NN
cord-276456-oa6hh7ky	297	18	with	with	IN
cord-276456-oa6hh7ky	297	19	intracellular	intracellular	JJ
cord-276456-oa6hh7ky	297	20	compartments	compartment	NNS
cord-276456-oa6hh7ky	297	21	/	/	SYM
cord-276456-oa6hh7ky	297	22	endosomes	endosome	NNS
cord-276456-oa6hh7ky	297	23	,	,	,
cord-276456-oa6hh7ky	297	24	131	131	CD
cord-276456-oa6hh7ky	297	25	and	and	CC
cord-276456-oa6hh7ky	297	26	the	the	DT
cord-276456-oa6hh7ky	297	27	use	use	NN
cord-276456-oa6hh7ky	297	28	of	of	IN
cord-276456-oa6hh7ky	297	29	solid	solid	JJ
cord-276456-oa6hh7ky	297	30	supported	support	VBN
cord-276456-oa6hh7ky	297	31	lipid	lipid	NN
cord-276456-oa6hh7ky	297	32	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	297	33	,	,	,
cord-276456-oa6hh7ky	297	34	132	132	CD
cord-276456-oa6hh7ky	297	35	facilitates	facilitate	VBZ
cord-276456-oa6hh7ky	297	36	a	a	DT
cord-276456-oa6hh7ky	297	37	more	more	RBR
cord-276456-oa6hh7ky	297	38	detailed	detailed	JJ
cord-276456-oa6hh7ky	297	39	analysis	analysis	NN
cord-276456-oa6hh7ky	297	40	of	of	IN
cord-276456-oa6hh7ky	297	41	the	the	DT
cord-276456-oa6hh7ky	297	42	single	single	JJ
cord-276456-oa6hh7ky	297	43	-	-	HYPH
cord-276456-oa6hh7ky	297	44	particle	particle	NN
cord-276456-oa6hh7ky	297	45	kinetics	kinetic	NNS
cord-276456-oa6hh7ky	297	46	of	of	IN
cord-276456-oa6hh7ky	297	47	HA	HA	NNP
cord-276456-oa6hh7ky	297	48	-	-	HYPH
cord-276456-oa6hh7ky	297	49	mediated	mediate	VBN
cord-276456-oa6hh7ky	297	50	fusion	fusion	NN
cord-276456-oa6hh7ky	297	51	as	as	RB
cord-276456-oa6hh7ky	297	52	well	well	RB
cord-276456-oa6hh7ky	297	53	as	as	IN
cord-276456-oa6hh7ky	297	54	SNARE	snare	NN
cord-276456-oa6hh7ky	297	55	-	-	HYPH
cord-276456-oa6hh7ky	297	56	mediated	mediate	VBN
cord-276456-oa6hh7ky	297	57	fusion	fusion	NN
cord-276456-oa6hh7ky	297	58	.	.	.
cord-276456-oa6hh7ky	298	1	85	85	CD
cord-276456-oa6hh7ky	299	1	In	in	IN
cord-276456-oa6hh7ky	299	2	combination	combination	NN
cord-276456-oa6hh7ky	299	3	with	with	IN
cord-276456-oa6hh7ky	299	4	assays	assay	NNS
cord-276456-oa6hh7ky	299	5	that	that	WDT
cord-276456-oa6hh7ky	299	6	reflect	reflect	VBP
cord-276456-oa6hh7ky	299	7	lipid	lipid	NN
cord-276456-oa6hh7ky	299	8	and	and	CC
cord-276456-oa6hh7ky	299	9	content	content	NN
cord-276456-oa6hh7ky	299	10	mixing	mixing	NN
cord-276456-oa6hh7ky	299	11	,	,	,
cord-276456-oa6hh7ky	299	12	together	together	RB
cord-276456-oa6hh7ky	299	13	with	with	IN
cord-276456-oa6hh7ky	299	14	pore	pore	NN
cord-276456-oa6hh7ky	299	15	formation	formation	NN
cord-276456-oa6hh7ky	299	16	and	and	CC
cord-276456-oa6hh7ky	299	17	expansion	expansion	NN
cord-276456-oa6hh7ky	299	18	,	,	,
cord-276456-oa6hh7ky	299	19	such	such	JJ
cord-276456-oa6hh7ky	299	20	approaches	approach	NNS
cord-276456-oa6hh7ky	299	21	are	be	VBP
cord-276456-oa6hh7ky	299	22	expected	expect	VBN
cord-276456-oa6hh7ky	299	23	to	to	TO
cord-276456-oa6hh7ky	299	24	contribute	contribute	VB
cord-276456-oa6hh7ky	299	25	substantially	substantially	RB
cord-276456-oa6hh7ky	299	26	towards	towards	IN
cord-276456-oa6hh7ky	299	27	providing	provide	VBG
cord-276456-oa6hh7ky	299	28	missing	miss	VBG
cord-276456-oa6hh7ky	299	29	information	information	NN
cord-276456-oa6hh7ky	299	30	regarding	regard	VBG
cord-276456-oa6hh7ky	299	31	the	the	DT
cord-276456-oa6hh7ky	299	32	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	299	33	and	and	CC
cord-276456-oa6hh7ky	299	34	pathways	pathway	NNS
cord-276456-oa6hh7ky	299	35	involved	involve	VBN
cord-276456-oa6hh7ky	299	36	in	in	IN
cord-276456-oa6hh7ky	299	37	fusion	fusion	NN
cord-276456-oa6hh7ky	299	38	.	.	.
cord-276456-oa6hh7ky	300	1	Membrane	membrane	NN
cord-276456-oa6hh7ky	300	2	Fusion	fusion	NN
cord-276456-oa6hh7ky	300	3	?	?	.
cord-276456-oa6hh7ky	301	1	Recent	recent	JJ
cord-276456-oa6hh7ky	301	2	work	work	NN
cord-276456-oa6hh7ky	301	3	has	have	VBZ
cord-276456-oa6hh7ky	301	4	shown	show	VBN
cord-276456-oa6hh7ky	301	5	that	that	IN
cord-276456-oa6hh7ky	301	6	two	two	CD
cord-276456-oa6hh7ky	301	7	rungs	rung	NNS
cord-276456-oa6hh7ky	301	8	of	of	IN
cord-276456-oa6hh7ky	301	9	a	a	DT
cord-276456-oa6hh7ky	301	10	dynamin	dynamin	NN
cord-276456-oa6hh7ky	301	11	spiral	spiral	NN
cord-276456-oa6hh7ky	301	12	is	be	VBZ
cord-276456-oa6hh7ky	301	13	the	the	DT
cord-276456-oa6hh7ky	301	14	minimal	minimal	JJ
cord-276456-oa6hh7ky	301	15	structural	structural	JJ
cord-276456-oa6hh7ky	301	16	unit	unit	NN
cord-276456-oa6hh7ky	301	17	responsible	responsible	JJ
cord-276456-oa6hh7ky	301	18	for	for	IN
cord-276456-oa6hh7ky	301	19	the	the	DT
cord-276456-oa6hh7ky	301	20	formation	formation	NN
cord-276456-oa6hh7ky	301	21	of	of	IN
cord-276456-oa6hh7ky	301	22	the	the	DT
cord-276456-oa6hh7ky	301	23	fission	fission	NN
cord-276456-oa6hh7ky	301	24	neck	neck	NN
cord-276456-oa6hh7ky	301	25	and	and	CC
cord-276456-oa6hh7ky	301	26	hemifission	hemifission	NN
cord-276456-oa6hh7ky	301	27	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	301	28	in	in	IN
cord-276456-oa6hh7ky	301	29	model	model	NN
cord-276456-oa6hh7ky	301	30	membrane	membrane	NN
cord-276456-oa6hh7ky	301	31	nanotubes	nanotube	NNS
cord-276456-oa6hh7ky	302	1	(	(	-LRB-
cord-276456-oa6hh7ky	302	2	Figure	figure	NN
cord-276456-oa6hh7ky	302	3	12	12	CD
cord-276456-oa6hh7ky	302	4	)	)	-RRB-
cord-276456-oa6hh7ky	302	5	.	.	.
cord-276456-oa6hh7ky	303	1	133	133	CD
cord-276456-oa6hh7ky	303	2	requires	require	VBZ
cord-276456-oa6hh7ky	303	3	the	the	DT
cord-276456-oa6hh7ky	303	4	same	same	JJ
cord-276456-oa6hh7ky	303	5	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	303	6	event	event	NN
cord-276456-oa6hh7ky	303	7	,	,	,
cord-276456-oa6hh7ky	303	8	but	but	CC
cord-276456-oa6hh7ky	303	9	in	in	IN
cord-276456-oa6hh7ky	303	10	a	a	DT
cord-276456-oa6hh7ky	303	11	cylindrically	cylindrically	RB
cord-276456-oa6hh7ky	303	12	symmetrical	symmetrical	JJ
cord-276456-oa6hh7ky	303	13	way	way	NN
cord-276456-oa6hh7ky	303	14	,	,	,
cord-276456-oa6hh7ky	303	15	as	as	IN
cord-276456-oa6hh7ky	303	16	the	the	DT
cord-276456-oa6hh7ky	303	17	inner	inner	JJ
cord-276456-oa6hh7ky	303	18	leaflet	leaflet	NN
cord-276456-oa6hh7ky	303	19	of	of	IN
cord-276456-oa6hh7ky	303	20	the	the	DT
cord-276456-oa6hh7ky	303	21	tube	tube	NN
cord-276456-oa6hh7ky	303	22	must	must	MD
cord-276456-oa6hh7ky	303	23	touch	touch	VB
cord-276456-oa6hh7ky	303	24	itself	-PRON-	PRP
cord-276456-oa6hh7ky	303	25	in	in	IN
cord-276456-oa6hh7ky	303	26	the	the	DT
cord-276456-oa6hh7ky	303	27	center	center	NN
cord-276456-oa6hh7ky	303	28	to	to	TO
cord-276456-oa6hh7ky	303	29	allow	allow	VB
cord-276456-oa6hh7ky	303	30	for	for	IN
cord-276456-oa6hh7ky	303	31	the	the	DT
cord-276456-oa6hh7ky	303	32	hemifission	hemifission	NN
cord-276456-oa6hh7ky	303	33	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	303	34	.	.	.
cord-276456-oa6hh7ky	304	1	Once	once	RB
cord-276456-oa6hh7ky	304	2	again	again	RB
cord-276456-oa6hh7ky	304	3	,	,	,
cord-276456-oa6hh7ky	304	4	it	-PRON-	PRP
cord-276456-oa6hh7ky	304	5	is	be	VBZ
cord-276456-oa6hh7ky	304	6	relatively	relatively	RB
cord-276456-oa6hh7ky	304	7	straightforward	straightforward	JJ
cord-276456-oa6hh7ky	304	8	to	to	TO
cord-276456-oa6hh7ky	304	9	calculate	calculate	VB
cord-276456-oa6hh7ky	304	10	the	the	DT
cord-276456-oa6hh7ky	304	11	ring	ring	NN
cord-276456-oa6hh7ky	304	12	conditions	condition	NNS
cord-276456-oa6hh7ky	304	13	that	that	WDT
cord-276456-oa6hh7ky	304	14	will	will	MD
cord-276456-oa6hh7ky	304	15	lead	lead	VB
cord-276456-oa6hh7ky	304	16	to	to	IN
cord-276456-oa6hh7ky	304	17	constriction	constriction	NN
cord-276456-oa6hh7ky	304	18	and	and	CC
cord-276456-oa6hh7ky	304	19	narrowing	narrowing	NN
cord-276456-oa6hh7ky	304	20	of	of	IN
cord-276456-oa6hh7ky	304	21	the	the	DT
cord-276456-oa6hh7ky	304	22	tube	tube	NN
cord-276456-oa6hh7ky	304	23	towards	towards	IN
cord-276456-oa6hh7ky	304	24	the	the	DT
cord-276456-oa6hh7ky	304	25	center	center	NN
cord-276456-oa6hh7ky	304	26	,	,	,
cord-276456-oa6hh7ky	304	27	as	as	RB
cord-276456-oa6hh7ky	304	28	long	long	RB
cord-276456-oa6hh7ky	304	29	as	as	IN
cord-276456-oa6hh7ky	304	30	the	the	DT
cord-276456-oa6hh7ky	304	31	distance	distance	NN
cord-276456-oa6hh7ky	304	32	between	between	IN
cord-276456-oa6hh7ky	304	33	the	the	DT
cord-276456-oa6hh7ky	304	34	two	two	CD
cord-276456-oa6hh7ky	304	35	rings	ring	NNS
cord-276456-oa6hh7ky	304	36	is	be	VBZ
cord-276456-oa6hh7ky	304	37	not	not	RB
cord-276456-oa6hh7ky	304	38	too	too	RB
cord-276456-oa6hh7ky	304	39	short	short	JJ
cord-276456-oa6hh7ky	304	40	.	.	.
cord-276456-oa6hh7ky	305	1	But	but	CC
cord-276456-oa6hh7ky	305	2	once	once	RB
cord-276456-oa6hh7ky	305	3	again	again	RB
cord-276456-oa6hh7ky	305	4	,	,	,
cord-276456-oa6hh7ky	305	5	we	-PRON-	PRP
cord-276456-oa6hh7ky	305	6	are	be	VBP
cord-276456-oa6hh7ky	305	7	faced	face	VBN
cord-276456-oa6hh7ky	305	8	with	with	IN
cord-276456-oa6hh7ky	305	9	the	the	DT
cord-276456-oa6hh7ky	305	10	hydration	hydration	NN
cord-276456-oa6hh7ky	305	11	force	force	NN
cord-276456-oa6hh7ky	305	12	resisting	resist	VBG
cord-276456-oa6hh7ky	305	13	any	any	DT
cord-276456-oa6hh7ky	305	14	further	further	JJ
cord-276456-oa6hh7ky	305	15	constriction	constriction	NN
cord-276456-oa6hh7ky	305	16	of	of	IN
cord-276456-oa6hh7ky	305	17	the	the	DT
cord-276456-oa6hh7ky	305	18	neck	neck	NN
cord-276456-oa6hh7ky	305	19	,	,	,
cord-276456-oa6hh7ky	305	20	since	since	IN
cord-276456-oa6hh7ky	305	21	the	the	DT
cord-276456-oa6hh7ky	305	22	surfaces	surface	NNS
cord-276456-oa6hh7ky	305	23	of	of	IN
cord-276456-oa6hh7ky	305	24	the	the	DT
cord-276456-oa6hh7ky	305	25	inner	inner	JJ
cord-276456-oa6hh7ky	305	26	leaflet	leaflet	NN
cord-276456-oa6hh7ky	305	27	lipids	lipid	NNS
cord-276456-oa6hh7ky	305	28	would	would	MD
cord-276456-oa6hh7ky	305	29	have	have	VB
cord-276456-oa6hh7ky	305	30	to	to	TO
cord-276456-oa6hh7ky	305	31	come	come	VB
cord-276456-oa6hh7ky	305	32	closer	close	RBR
cord-276456-oa6hh7ky	305	33	than	than	IN
cord-276456-oa6hh7ky	305	34	the	the	DT
cord-276456-oa6hh7ky	305	35	2	2	CD
cord-276456-oa6hh7ky	305	36	nm	nm	NN
cord-276456-oa6hh7ky	305	37	equilibrium	equilibrium	JJ
cord-276456-oa6hh7ky	305	38	distance	distance	NN
cord-276456-oa6hh7ky	305	39	between	between	IN
cord-276456-oa6hh7ky	305	40	attractive	attractive	JJ
cord-276456-oa6hh7ky	305	41	dispersion	dispersion	NN
cord-276456-oa6hh7ky	305	42	forces	force	NNS
cord-276456-oa6hh7ky	305	43	and	and	CC
cord-276456-oa6hh7ky	305	44	repulsive	repulsive	JJ
cord-276456-oa6hh7ky	305	45	hydration	hydration	NN
cord-276456-oa6hh7ky	305	46	forces	force	NNS
cord-276456-oa6hh7ky	305	47	.	.	.
cord-276456-oa6hh7ky	306	1	But	but	CC
cord-276456-oa6hh7ky	306	2	lo	lo	NNP
cord-276456-oa6hh7ky	306	3	,	,	,
cord-276456-oa6hh7ky	306	4	there	there	EX
cord-276456-oa6hh7ky	306	5	is	be	VBZ
cord-276456-oa6hh7ky	306	6	a	a	DT
cord-276456-oa6hh7ky	306	7	new	new	JJ
cord-276456-oa6hh7ky	306	8	modality	modality	NN
cord-276456-oa6hh7ky	306	9	for	for	IN
cord-276456-oa6hh7ky	306	10	minimizing	minimize	VBG
cord-276456-oa6hh7ky	306	11	energy	energy	NN
cord-276456-oa6hh7ky	306	12	in	in	IN
cord-276456-oa6hh7ky	306	13	this	this	DT
cord-276456-oa6hh7ky	306	14	system	system	NN
cord-276456-oa6hh7ky	306	15	;	;	:
cord-276456-oa6hh7ky	306	16	it	-PRON-	PRP
cord-276456-oa6hh7ky	306	17	is	be	VBZ
cord-276456-oa6hh7ky	306	18	the	the	DT
cord-276456-oa6hh7ky	306	19	tilt	tilt	NN
cord-276456-oa6hh7ky	306	20	-	-	HYPH
cord-276456-oa6hh7ky	306	21	like	like	JJ
cord-276456-oa6hh7ky	306	22	movement	movement	NN
cord-276456-oa6hh7ky	306	23	of	of	IN
cord-276456-oa6hh7ky	306	24	lipid	lipid	NN
cord-276456-oa6hh7ky	306	25	head	head	NN
cord-276456-oa6hh7ky	306	26	groups	group	NNS
cord-276456-oa6hh7ky	306	27	away	away	RB
cord-276456-oa6hh7ky	306	28	from	from	IN
cord-276456-oa6hh7ky	306	29	each	each	DT
cord-276456-oa6hh7ky	306	30	other	other	JJ
cord-276456-oa6hh7ky	306	31	at	at	IN
cord-276456-oa6hh7ky	306	32	the	the	DT
cord-276456-oa6hh7ky	306	33	very	very	JJ
cord-276456-oa6hh7ky	306	34	center	center	NN
cord-276456-oa6hh7ky	306	35	of	of	IN
cord-276456-oa6hh7ky	306	36	the	the	DT
cord-276456-oa6hh7ky	306	37	hourglass	hourglass	NN
cord-276456-oa6hh7ky	306	38	constriction	constriction	NN
cord-276456-oa6hh7ky	306	39	of	of	IN
cord-276456-oa6hh7ky	306	40	the	the	DT
cord-276456-oa6hh7ky	306	41	neck	neck	NN
cord-276456-oa6hh7ky	306	42	(	(	-LRB-
cord-276456-oa6hh7ky	306	43	Figure	figure	NN
cord-276456-oa6hh7ky	306	44	12	12	CD
cord-276456-oa6hh7ky	306	45	in	in	IN
cord-276456-oa6hh7ky	306	46	formation	formation	NN
cord-276456-oa6hh7ky	306	47	of	of	IN
cord-276456-oa6hh7ky	306	48	a	a	DT
cord-276456-oa6hh7ky	306	49	narrow	narrow	JJ
cord-276456-oa6hh7ky	306	50	separation	separation	NN
cord-276456-oa6hh7ky	306	51	of	of	IN
cord-276456-oa6hh7ky	306	52	heads	head	NNS
cord-276456-oa6hh7ky	306	53	exposing	expose	VBG
cord-276456-oa6hh7ky	306	54	the	the	DT
cord-276456-oa6hh7ky	306	55	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	306	56	interior	interior	NN
cord-276456-oa6hh7ky	306	57	of	of	IN
cord-276456-oa6hh7ky	306	58	the	the	DT
cord-276456-oa6hh7ky	306	59	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	306	60	,	,	,
cord-276456-oa6hh7ky	306	61	termed	term	VBD
cord-276456-oa6hh7ky	306	62	a	a	DT
cord-276456-oa6hh7ky	306	63	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	306	64	'	'	''
cord-276456-oa6hh7ky	306	65	'	'	``
cord-276456-oa6hh7ky	306	66	belt	belt	NN
cord-276456-oa6hh7ky	306	67	'	'	''
cord-276456-oa6hh7ky	306	68	'	'	''
cord-276456-oa6hh7ky	306	69	to	to	TO
cord-276456-oa6hh7ky	306	70	indicate	indicate	VB
cord-276456-oa6hh7ky	306	71	its	-PRON-	PRP$
cord-276456-oa6hh7ky	306	72	presence	presence	NN
cord-276456-oa6hh7ky	306	73	as	as	IN
cord-276456-oa6hh7ky	306	74	a	a	DT
cord-276456-oa6hh7ky	306	75	ring	ring	NN
cord-276456-oa6hh7ky	306	76	(	(	-LRB-
cord-276456-oa6hh7ky	306	77	you	-PRON-	PRP
cord-276456-oa6hh7ky	306	78	can	can	MD
cord-276456-oa6hh7ky	306	79	visualize	visualize	VB
cord-276456-oa6hh7ky	306	80	this	this	DT
cord-276456-oa6hh7ky	306	81	ring	ring	NN
cord-276456-oa6hh7ky	306	82	by	by	IN
cord-276456-oa6hh7ky	306	83	rotating	rotate	VBG
cord-276456-oa6hh7ky	306	84	the	the	DT
cord-276456-oa6hh7ky	306	85	figures	figure	NNS
cord-276456-oa6hh7ky	306	86	of	of	IN
cord-276456-oa6hh7ky	306	87	Figure	figure	NN
cord-276456-oa6hh7ky	306	88	12	12	CD
cord-276456-oa6hh7ky	306	89	(	(	-LRB-
cord-276456-oa6hh7ky	306	90	a	a	LS
cord-276456-oa6hh7ky	306	91	)	)	-RRB-
cord-276456-oa6hh7ky	306	92	around	around	IN
cord-276456-oa6hh7ky	306	93	the	the	DT
cord-276456-oa6hh7ky	306	94	axis	axis	NN
cord-276456-oa6hh7ky	306	95	of	of	IN
cord-276456-oa6hh7ky	306	96	the	the	DT
cord-276456-oa6hh7ky	306	97	horizontal	horizontal	JJ
cord-276456-oa6hh7ky	306	98	dashed	dash	VBN
cord-276456-oa6hh7ky	306	99	line	line	NN
cord-276456-oa6hh7ky	306	100	under	under	IN
cord-276456-oa6hh7ky	306	101	each	each	DT
cord-276456-oa6hh7ky	306	102	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	306	103	)	)	-RRB-
cord-276456-oa6hh7ky	306	104	.	.	.
cord-276456-oa6hh7ky	307	1	Now	now	RB
cord-276456-oa6hh7ky	307	2	the	the	DT
cord-276456-oa6hh7ky	307	3	repulsive	repulsive	JJ
cord-276456-oa6hh7ky	307	4	hydration	hydration	NN
cord-276456-oa6hh7ky	307	5	force	force	NN
cord-276456-oa6hh7ky	307	6	stabilizing	stabilize	VBG
cord-276456-oa6hh7ky	307	7	inner	inner	JJ
cord-276456-oa6hh7ky	307	8	aqueous	aqueous	JJ
cord-276456-oa6hh7ky	307	9	diameters	diameter	NNS
cord-276456-oa6hh7ky	307	10	of	of	IN
cord-276456-oa6hh7ky	307	11	2	2	CD
cord-276456-oa6hh7ky	307	12	nm	nm	NN
cord-276456-oa6hh7ky	307	13	gives	give	VBZ
cord-276456-oa6hh7ky	307	14	way	way	NN
cord-276456-oa6hh7ky	307	15	to	to	IN
cord-276456-oa6hh7ky	307	16	a	a	DT
cord-276456-oa6hh7ky	307	17	newly	newly	RB
cord-276456-oa6hh7ky	307	18	developed	develop	VBN
cord-276456-oa6hh7ky	307	19	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	307	20	attractive	attractive	JJ
cord-276456-oa6hh7ky	307	21	force	force	NN
cord-276456-oa6hh7ky	307	22	,	,	,
cord-276456-oa6hh7ky	307	23	which	which	WDT
cord-276456-oa6hh7ky	307	24	is	be	VBZ
cord-276456-oa6hh7ky	307	25	effectively	effectively	RB
cord-276456-oa6hh7ky	307	26	the	the	DT
cord-276456-oa6hh7ky	307	27	desire	desire	NN
cord-276456-oa6hh7ky	307	28	of	of	IN
cord-276456-oa6hh7ky	307	29	water	water	NN
cord-276456-oa6hh7ky	307	30	to	to	TO
cord-276456-oa6hh7ky	307	31	desolvate	desolvate	VB
cord-276456-oa6hh7ky	307	32	the	the	DT
cord-276456-oa6hh7ky	307	33	space	space	NN
cord-276456-oa6hh7ky	307	34	between	between	IN
cord-276456-oa6hh7ky	307	35	the	the	DT
cord-276456-oa6hh7ky	307	36	tilting	tilt	VBG
cord-276456-oa6hh7ky	307	37	headgroups	headgroups	NNP
cord-276456-oa6hh7ky	307	38	in	in	IN
cord-276456-oa6hh7ky	307	39	the	the	DT
cord-276456-oa6hh7ky	307	40	center	center	NN
cord-276456-oa6hh7ky	307	41	.	.	.
cord-276456-oa6hh7ky	308	1	This	this	DT
cord-276456-oa6hh7ky	308	2	water	water	NN
cord-276456-oa6hh7ky	308	3	ejection	ejection	NN
cord-276456-oa6hh7ky	308	4	leads	lead	VBZ
cord-276456-oa6hh7ky	308	5	to	to	IN
cord-276456-oa6hh7ky	308	6	the	the	DT
cord-276456-oa6hh7ky	308	7	close	close	JJ
cord-276456-oa6hh7ky	308	8	approximation	approximation	NN
cord-276456-oa6hh7ky	308	9	and	and	CC
cord-276456-oa6hh7ky	308	10	finally	finally	RB
cord-276456-oa6hh7ky	308	11	merger	merger	NN
cord-276456-oa6hh7ky	308	12	of	of	IN
cord-276456-oa6hh7ky	308	13	the	the	DT
cord-276456-oa6hh7ky	308	14	neck	neck	NN
cord-276456-oa6hh7ky	308	15	with	with	IN
cord-276456-oa6hh7ky	308	16	itself	-PRON-	PRP
cord-276456-oa6hh7ky	308	17	at	at	IN
cord-276456-oa6hh7ky	308	18	the	the	DT
cord-276456-oa6hh7ky	308	19	midpoint	midpoint	NN
cord-276456-oa6hh7ky	308	20	;	;	:
cord-276456-oa6hh7ky	308	21	that	that	RB
cord-276456-oa6hh7ky	308	22	is	is	RB
cord-276456-oa6hh7ky	308	23	,	,	,
cord-276456-oa6hh7ky	308	24	its	-PRON-	PRP$
cord-276456-oa6hh7ky	308	25	closure	closure	NN
cord-276456-oa6hh7ky	308	26	.	.	.
cord-276456-oa6hh7ky	309	1	Figure	figure	NN
cord-276456-oa6hh7ky	309	2	12	12	CD
cord-276456-oa6hh7ky	310	1	(	(	-LRB-
cord-276456-oa6hh7ky	310	2	d	d	NN
cord-276456-oa6hh7ky	310	3	)	)	-RRB-
cord-276456-oa6hh7ky	310	4	shows	show	VBZ
cord-276456-oa6hh7ky	310	5	the	the	DT
cord-276456-oa6hh7ky	310	6	calculated	calculate	VBN
cord-276456-oa6hh7ky	310	7	energy	energy	NN
cord-276456-oa6hh7ky	310	8	of	of	IN
cord-276456-oa6hh7ky	310	9	a	a	DT
cord-276456-oa6hh7ky	310	10	9-mm	9-mm	CD
cord-276456-oa6hh7ky	310	11	-	-	HYPH
cord-276456-oa6hh7ky	310	12	long	long	JJ
cord-276456-oa6hh7ky	310	13	segment	segment	NN
cord-276456-oa6hh7ky	310	14	of	of	IN
cord-276456-oa6hh7ky	310	15	neck	neck	NN
cord-276456-oa6hh7ky	310	16	,	,	,
cord-276456-oa6hh7ky	310	17	depending	depend	VBG
cord-276456-oa6hh7ky	310	18	upon	upon	IN
cord-276456-oa6hh7ky	310	19	the	the	DT
cord-276456-oa6hh7ky	310	20	width	width	NN
cord-276456-oa6hh7ky	310	21	(	(	-LRB-
cord-276456-oa6hh7ky	310	22	H	h	NN
cord-276456-oa6hh7ky	310	23	)	)	-RRB-
cord-276456-oa6hh7ky	310	24	and	and	CC
cord-276456-oa6hh7ky	310	25	radius	radius	NN
cord-276456-oa6hh7ky	310	26	(	(	-LRB-
cord-276456-oa6hh7ky	310	27	Rmid	Rmid	NNP
cord-276456-oa6hh7ky	310	28	)	)	-RRB-
cord-276456-oa6hh7ky	310	29	of	of	IN
cord-276456-oa6hh7ky	310	30	the	the	DT
cord-276456-oa6hh7ky	310	31	hydrophobic	hydrophobic	JJ
cord-276456-oa6hh7ky	310	32	belt	belt	NN
cord-276456-oa6hh7ky	310	33	discussed	discuss	VBN
cord-276456-oa6hh7ky	310	34	above	above	RB
cord-276456-oa6hh7ky	310	35	.	.	.
cord-276456-oa6hh7ky	311	1	Like	like	IN
cord-276456-oa6hh7ky	311	2	the	the	DT
cord-276456-oa6hh7ky	311	3	stalk	stalk	NN
cord-276456-oa6hh7ky	311	4	,	,	,
cord-276456-oa6hh7ky	311	5	the	the	DT
cord-276456-oa6hh7ky	311	6	belt	belt	NN
cord-276456-oa6hh7ky	311	7	width	width	NN
cord-276456-oa6hh7ky	311	8	becomes	become	VBZ
cord-276456-oa6hh7ky	311	9	that	that	DT
cord-276456-oa6hh7ky	311	10	of	of	IN
cord-276456-oa6hh7ky	311	11	a	a	DT
cord-276456-oa6hh7ky	311	12	single	single	JJ
cord-276456-oa6hh7ky	311	13	monolayer	monolayer	NN
cord-276456-oa6hh7ky	311	14	at	at	IN
cord-276456-oa6hh7ky	311	15	the	the	DT
cord-276456-oa6hh7ky	311	16	point	point	NN
cord-276456-oa6hh7ky	311	17	of	of	IN
cord-276456-oa6hh7ky	311	18	merger	merger	NN
cord-276456-oa6hh7ky	311	19	.	.	.
cord-276456-oa6hh7ky	312	1	The	the	DT
cord-276456-oa6hh7ky	312	2	energy	energy	NN
cord-276456-oa6hh7ky	312	3	barrier	barrier	NN
cord-276456-oa6hh7ky	312	4	of	of	IN
cord-276456-oa6hh7ky	312	5	35	35	CD
cord-276456-oa6hh7ky	312	6	k	k	NN
cord-276456-oa6hh7ky	312	7	B	b	NN
cord-276456-oa6hh7ky	312	8	T	T	NNP
cord-276456-oa6hh7ky	312	9	is	be	VBZ
cord-276456-oa6hh7ky	312	10	also	also	RB
cord-276456-oa6hh7ky	312	11	similar	similar	JJ
cord-276456-oa6hh7ky	312	12	to	to	IN
cord-276456-oa6hh7ky	312	13	those	those	DT
cord-276456-oa6hh7ky	312	14	calculated	calculate	VBN
cord-276456-oa6hh7ky	312	15	for	for	IN
cord-276456-oa6hh7ky	312	16	membrane	membrane	NN
cord-276456-oa6hh7ky	312	17	fusion	fusion	NN
cord-276456-oa6hh7ky	312	18	,	,	,
cord-276456-oa6hh7ky	312	19	24	24	CD
cord-276456-oa6hh7ky	312	20	so	so	IN
cord-276456-oa6hh7ky	312	21	it	-PRON-	PRP
cord-276456-oa6hh7ky	312	22	is	be	VBZ
cord-276456-oa6hh7ky	312	23	energetically	energetically	RB
cord-276456-oa6hh7ky	312	24	feasible	feasible	JJ
cord-276456-oa6hh7ky	312	25	.	.	.
cord-276456-oa6hh7ky	313	1	The	the	DT
cord-276456-oa6hh7ky	313	2	lipid	lipid	NN
cord-276456-oa6hh7ky	313	3	bending	bend	VBG
cord-276456-oa6hh7ky	313	4	and	and	CC
cord-276456-oa6hh7ky	313	5	tilting	tilt	VBG
cord-276456-oa6hh7ky	313	6	needed	need	VBN
cord-276456-oa6hh7ky	313	7	to	to	TO
cord-276456-oa6hh7ky	313	8	catalyze	catalyze	VB
cord-276456-oa6hh7ky	313	9	membrane	membrane	NN
cord-276456-oa6hh7ky	313	10	merger	merger	NN
cord-276456-oa6hh7ky	313	11	are	be	VBP
cord-276456-oa6hh7ky	313	12	mainly	mainly	RB
cord-276456-oa6hh7ky	313	13	motivated	motivate	VBN
cord-276456-oa6hh7ky	313	14	by	by	IN
cord-276456-oa6hh7ky	313	15	high	high	JJ
cord-276456-oa6hh7ky	313	16	curvature	curvature	NN
cord-276456-oa6hh7ky	313	17	stress	stress	NN
cord-276456-oa6hh7ky	313	18	in	in	IN
cord-276456-oa6hh7ky	313	19	the	the	DT
cord-276456-oa6hh7ky	313	20	neck	neck	NN
cord-276456-oa6hh7ky	313	21	inner	inner	JJ
cord-276456-oa6hh7ky	313	22	leaflet	leaflet	NN
cord-276456-oa6hh7ky	313	23	.	.	.
cord-276456-oa6hh7ky	314	1	Accordingly	accordingly	RB
cord-276456-oa6hh7ky	314	2	,	,	,
cord-276456-oa6hh7ky	314	3	the	the	DT
cord-276456-oa6hh7ky	314	4	energy	energy	NN
cord-276456-oa6hh7ky	314	5	barrier	barrier	NN
cord-276456-oa6hh7ky	314	6	depends	depend	VBZ
cord-276456-oa6hh7ky	314	7	sharply	sharply	RB
cord-276456-oa6hh7ky	314	8	on	on	IN
cord-276456-oa6hh7ky	314	9	the	the	DT
cord-276456-oa6hh7ky	314	10	minimal	minimal	JJ
cord-276456-oa6hh7ky	314	11	radius	radius	NN
cord-276456-oa6hh7ky	314	12	of	of	IN
cord-276456-oa6hh7ky	314	13	the	the	DT
cord-276456-oa6hh7ky	314	14	thinned	thin	VBN
cord-276456-oa6hh7ky	314	15	neck	neck	NN
cord-276456-oa6hh7ky	314	16	,	,	,
cord-276456-oa6hh7ky	314	17	Rmin	Rmin	NNP
cord-276456-oa6hh7ky	314	18	,	,	,
cord-276456-oa6hh7ky	314	19	which	which	WDT
cord-276456-oa6hh7ky	314	20	should	should	MD
cord-276456-oa6hh7ky	314	21	approach	approach	VB
cord-276456-oa6hh7ky	314	22	1	1	CD
cord-276456-oa6hh7ky	314	23	-	-	SYM
cord-276456-oa6hh7ky	314	24	2	2	CD
cord-276456-oa6hh7ky	314	25	nm	nm	NN
cord-276456-oa6hh7ky	314	26	for	for	IN
cord-276456-oa6hh7ky	314	27	the	the	DT
cord-276456-oa6hh7ky	314	28	fission	fission	NN
cord-276456-oa6hh7ky	314	29	to	to	TO
cord-276456-oa6hh7ky	314	30	occur	occur	VB
cord-276456-oa6hh7ky	314	31	,	,	,
cord-276456-oa6hh7ky	314	32	as	as	IN
cord-276456-oa6hh7ky	314	33	seen	see	VBN
cord-276456-oa6hh7ky	314	34	in	in	IN
cord-276456-oa6hh7ky	314	35	other	other	JJ
cord-276456-oa6hh7ky	314	36	estimations	estimation	NNS
cord-276456-oa6hh7ky	314	37	of	of	IN
cord-276456-oa6hh7ky	314	38	hemifission	hemifission	NN
cord-276456-oa6hh7ky	314	39	.	.	.
cord-276456-oa6hh7ky	315	1	135	135	CD
cord-276456-oa6hh7ky	316	1	Thus	thus	RB
cord-276456-oa6hh7ky	316	2	the	the	DT
cord-276456-oa6hh7ky	316	3	rings	ring	NNS
cord-276456-oa6hh7ky	316	4	of	of	IN
cord-276456-oa6hh7ky	316	5	protein	protein	NN
cord-276456-oa6hh7ky	316	6	acting	act	VBG
cord-276456-oa6hh7ky	316	7	on	on	IN
cord-276456-oa6hh7ky	316	8	the	the	DT
cord-276456-oa6hh7ky	316	9	outside	outside	NN
cord-276456-oa6hh7ky	316	10	of	of	IN
cord-276456-oa6hh7ky	316	11	a	a	DT
cord-276456-oa6hh7ky	316	12	12	12	CD
cord-276456-oa6hh7ky	316	13	nm	nm	NN
cord-276456-oa6hh7ky	316	14	tube	tube	NN
cord-276456-oa6hh7ky	316	15	lead	lead	NN
cord-276456-oa6hh7ky	316	16	to	to	IN
cord-276456-oa6hh7ky	316	17	boundary	boundary	JJ
cord-276456-oa6hh7ky	316	18	conditions	condition	NNS
cord-276456-oa6hh7ky	316	19	whose	whose	WP$
cord-276456-oa6hh7ky	316	20	effects	effect	NNS
cord-276456-oa6hh7ky	316	21	propagate	propagate	VBP
cord-276456-oa6hh7ky	316	22	through	through	IN
cord-276456-oa6hh7ky	316	23	the	the	DT
cord-276456-oa6hh7ky	316	24	bilayer	bilayer	NN
cord-276456-oa6hh7ky	316	25	to	to	TO
cord-276456-oa6hh7ky	316	26	influence	influence	VB
cord-276456-oa6hh7ky	316	27	and	and	CC
cord-276456-oa6hh7ky	316	28	stress	stress	NN
cord-276456-oa6hh7ky	316	29	lipids	lipid	NNS
cord-276456-oa6hh7ky	316	30	facing	face	VBG
cord-276456-oa6hh7ky	316	31	each	each	DT
cord-276456-oa6hh7ky	316	32	other	other	JJ
cord-276456-oa6hh7ky	316	33	across	across	IN
cord-276456-oa6hh7ky	316	34	water	water	NN
cord-276456-oa6hh7ky	316	35	,	,	,
cord-276456-oa6hh7ky	316	36	leading	lead	VBG
cord-276456-oa6hh7ky	316	37	to	to	IN
cord-276456-oa6hh7ky	316	38	their	-PRON-	PRP$
cord-276456-oa6hh7ky	316	39	head	head	NN
cord-276456-oa6hh7ky	316	40	groups	group	NNS
cord-276456-oa6hh7ky	316	41	parting	part	VBG
cord-276456-oa6hh7ky	316	42	and	and	CC
cord-276456-oa6hh7ky	316	43	their	-PRON-	PRP$
cord-276456-oa6hh7ky	316	44	oils	oil	NNS
cord-276456-oa6hh7ky	316	45	merging	merge	VBG
cord-276456-oa6hh7ky	316	46	in	in	IN
cord-276456-oa6hh7ky	316	47	energetically	energetically	RB
cord-276456-oa6hh7ky	316	48	feasible	feasible	JJ
cord-276456-oa6hh7ky	316	49	hemifission	hemifission	NN
cord-276456-oa6hh7ky	316	50	.	.	.
cord-276456-oa6hh7ky	317	1	The	the	DT
cord-276456-oa6hh7ky	317	2	proteins	protein	NNS
cord-276456-oa6hh7ky	317	3	act	act	VBP
cord-276456-oa6hh7ky	317	4	at	at	IN
cord-276456-oa6hh7ky	317	5	length	length	NN
cord-276456-oa6hh7ky	317	6	scales	scale	NNS
cord-276456-oa6hh7ky	317	7	consistent	consistent	JJ
cord-276456-oa6hh7ky	317	8	with	with	IN
cord-276456-oa6hh7ky	317	9	what	what	WP
cord-276456-oa6hh7ky	317	10	we	-PRON-	PRP
cord-276456-oa6hh7ky	317	11	know	know	VBP
cord-276456-oa6hh7ky	317	12	about	about	IN
cord-276456-oa6hh7ky	317	13	protein	protein	NN
cord-276456-oa6hh7ky	317	14	structural	structural	JJ
cord-276456-oa6hh7ky	317	15	lengths	length	NNS
cord-276456-oa6hh7ky	317	16	,	,	,
cord-276456-oa6hh7ky	317	17	and	and	CC
cord-276456-oa6hh7ky	317	18	the	the	DT
cord-276456-oa6hh7ky	317	19	lipids	lipid	NNS
cord-276456-oa6hh7ky	317	20	respond	respond	VBP
cord-276456-oa6hh7ky	317	21	fluidly	fluidly	RB
cord-276456-oa6hh7ky	317	22	to	to	IN
cord-276456-oa6hh7ky	317	23	the	the	DT
cord-276456-oa6hh7ky	317	24	protein	protein	NN
cord-276456-oa6hh7ky	317	25	's	's	POS
cord-276456-oa6hh7ky	317	26	influence	influence	NN
cord-276456-oa6hh7ky	317	27	.	.	.
cord-276456-oa6hh7ky	318	1	Mechanistic	mechanistic	JJ
cord-276456-oa6hh7ky	318	2	studies	study	NNS
cord-276456-oa6hh7ky	318	3	concerning	concern	VBG
cord-276456-oa6hh7ky	318	4	dynamin	dynamin	NNP
cord-276456-oa6hh7ky	318	5	offer	offer	VBP
cord-276456-oa6hh7ky	318	6	not	not	RB
cord-276456-oa6hh7ky	318	7	only	only	RB
cord-276456-oa6hh7ky	318	8	a	a	DT
cord-276456-oa6hh7ky	318	9	static	static	JJ
cord-276456-oa6hh7ky	318	10	view	view	NN
cord-276456-oa6hh7ky	318	11	of	of	IN
cord-276456-oa6hh7ky	318	12	the	the	DT
cord-276456-oa6hh7ky	318	13	energetics	energetic	NNS
cord-276456-oa6hh7ky	318	14	of	of	IN
cord-276456-oa6hh7ky	318	15	non	non	JJ
cord-276456-oa6hh7ky	318	16	-	-	JJ
cord-276456-oa6hh7ky	318	17	leaky	leaky	JJ
cord-276456-oa6hh7ky	318	18	fission	fission	NN
cord-276456-oa6hh7ky	318	19	/	/	SYM
cord-276456-oa6hh7ky	318	20	fusion	fusion	NN
cord-276456-oa6hh7ky	318	21	reactions	reaction	NNS
cord-276456-oa6hh7ky	318	22	but	but	CC
cord-276456-oa6hh7ky	318	23	also	also	RB
cord-276456-oa6hh7ky	318	24	insights	insight	VBZ
cord-276456-oa6hh7ky	318	25	into	into	IN
cord-276456-oa6hh7ky	318	26	the	the	DT
cord-276456-oa6hh7ky	318	27	dynamics	dynamic	NNS
cord-276456-oa6hh7ky	318	28	of	of	IN
cord-276456-oa6hh7ky	318	29	the	the	DT
cord-276456-oa6hh7ky	318	30	transition	transition	NN
cord-276456-oa6hh7ky	318	31	structures	structure	NNS
cord-276456-oa6hh7ky	318	32	.	.	.
cord-276456-oa6hh7ky	319	1	Dynamin	Dynamin	NNP
cord-276456-oa6hh7ky	319	2	assembly	assembly	NN
cord-276456-oa6hh7ky	319	3	shapes	shape	NNS
cord-276456-oa6hh7ky	319	4	bilayers	bilayer	VBZ
cord-276456-oa6hh7ky	319	5	into	into	IN
cord-276456-oa6hh7ky	319	6	highly	highly	RB
cord-276456-oa6hh7ky	319	7	curved	curved	JJ
cord-276456-oa6hh7ky	319	8	structures	structure	NNS
cord-276456-oa6hh7ky	319	9	(	(	-LRB-
cord-276456-oa6hh7ky	319	10	Figure	figure	NN
cord-276456-oa6hh7ky	319	11	12	12	CD
cord-276456-oa6hh7ky	319	12	)	)	-RRB-
cord-276456-oa6hh7ky	319	13	.	.	.
cord-276456-oa6hh7ky	320	1	Assembly	assembly	NN
cord-276456-oa6hh7ky	320	2	also	also	RB
cord-276456-oa6hh7ky	320	3	greatly	greatly	RB
cord-276456-oa6hh7ky	320	4	enhances	enhance	VBZ
cord-276456-oa6hh7ky	320	5	the	the	DT
cord-276456-oa6hh7ky	320	6	rate	rate	NN
cord-276456-oa6hh7ky	320	7	of	of	IN
cord-276456-oa6hh7ky	320	8	GTP	gtp	NN
cord-276456-oa6hh7ky	320	9	hydrolysis	hydrolysis	NN
cord-276456-oa6hh7ky	320	10	(	(	-LRB-
cord-276456-oa6hh7ky	320	11	100-fold	100-fold	CD
cord-276456-oa6hh7ky	320	12	)	)	-RRB-
cord-276456-oa6hh7ky	320	13	,	,	,
cord-276456-oa6hh7ky	320	14	136	136	CD
cord-276456-oa6hh7ky	320	15	which	which	WDT
cord-276456-oa6hh7ky	320	16	in	in	IN
cord-276456-oa6hh7ky	320	17	turn	turn	NN
cord-276456-oa6hh7ky	320	18	leads	lead	VBZ
cord-276456-oa6hh7ky	320	19	to	to	IN
cord-276456-oa6hh7ky	320	20	dynamin	dynamin	NNP
cord-276456-oa6hh7ky	320	21	disassembly	disassembly	NNP
cord-276456-oa6hh7ky	320	22	.	.	.
cord-276456-oa6hh7ky	321	1	Thus	thus	RB
cord-276456-oa6hh7ky	321	2	,	,	,
cord-276456-oa6hh7ky	321	3	assembly	assembly	NN
cord-276456-oa6hh7ky	321	4	is	be	VBZ
cord-276456-oa6hh7ky	321	5	self	self	NN
cord-276456-oa6hh7ky	321	6	-	-	HYPH
cord-276456-oa6hh7ky	321	7	limited	limit	VBN
cord-276456-oa6hh7ky	321	8	in	in	IN
cord-276456-oa6hh7ky	321	9	the	the	DT
cord-276456-oa6hh7ky	321	10	presence	presence	NN
cord-276456-oa6hh7ky	321	11	of	of	IN
cord-276456-oa6hh7ky	321	12	GTP	GTP	NNP
cord-276456-oa6hh7ky	321	13	.	.	.
cord-276456-oa6hh7ky	322	1	Recent	recent	JJ
cord-276456-oa6hh7ky	322	2	experiments	experiment	NNS
cord-276456-oa6hh7ky	322	3	suggest	suggest	VBP
cord-276456-oa6hh7ky	322	4	that	that	IN
cord-276456-oa6hh7ky	322	5	assembly	assembly	NN
cord-276456-oa6hh7ky	322	6	-	-	HYPH
cord-276456-oa6hh7ky	322	7	induced	induce	VBN
cord-276456-oa6hh7ky	322	8	GTPase	GTPase	NNP
cord-276456-oa6hh7ky	322	9	activity	activity	NN
cord-276456-oa6hh7ky	322	10	reduces	reduce	VBZ
cord-276456-oa6hh7ky	322	11	the	the	DT
cord-276456-oa6hh7ky	322	12	interaction	interaction	NN
cord-276456-oa6hh7ky	322	13	of	of	IN
cord-276456-oa6hh7ky	322	14	dynamin	dynamin	NNP
cord-276456-oa6hh7ky	322	15	with	with	IN
cord-276456-oa6hh7ky	322	16	the	the	DT
cord-276456-oa6hh7ky	322	17	highly	highly	RB
cord-276456-oa6hh7ky	322	18	curved	curved	JJ
cord-276456-oa6hh7ky	322	19	lipid	lipid	NN
cord-276456-oa6hh7ky	322	20	membrane	membrane	NN
cord-276456-oa6hh7ky	322	21	even	even	RB
cord-276456-oa6hh7ky	322	22	before	before	IN
cord-276456-oa6hh7ky	322	23	disassembly	disassembly	NN
cord-276456-oa6hh7ky	322	24	.	.	.
cord-276456-oa6hh7ky	323	1	137	137	CD
cord-276456-oa6hh7ky	324	1	The	the	DT
cord-276456-oa6hh7ky	324	2	result	result	NN
cord-276456-oa6hh7ky	324	3	is	be	VBZ
cord-276456-oa6hh7ky	324	4	the	the	DT
cord-276456-oa6hh7ky	324	5	unstable	unstable	JJ
cord-276456-oa6hh7ky	324	6	,	,	,
cord-276456-oa6hh7ky	324	7	highly	highly	RB
cord-276456-oa6hh7ky	324	8	curved	curved	JJ
cord-276456-oa6hh7ky	324	9	lipid	lipid	NN
cord-276456-oa6hh7ky	324	10	neck	neck	NN
cord-276456-oa6hh7ky	324	11	described	describe	VBN
cord-276456-oa6hh7ky	324	12	above	above	IN
cord-276456-oa6hh7ky	324	13	that	that	DT
cord-276456-oa6hh7ky	324	14	resolves	resolve	VBZ
cord-276456-oa6hh7ky	324	15	either	either	CC
cord-276456-oa6hh7ky	324	16	in	in	IN
cord-276456-oa6hh7ky	324	17	membrane	membrane	NN
cord-276456-oa6hh7ky	324	18	fission	fission	NN
cord-276456-oa6hh7ky	324	19	(	(	-LRB-
cord-276456-oa6hh7ky	324	20	endocytosis	endocytosis	NN
cord-276456-oa6hh7ky	324	21	,	,	,
cord-276456-oa6hh7ky	324	22	described	describe	VBN
cord-276456-oa6hh7ky	324	23	above	above	IN
cord-276456-oa6hh7ky	324	24	)	)	-RRB-
cord-276456-oa6hh7ky	324	25	,	,	,
cord-276456-oa6hh7ky	324	26	or	or	CC
cord-276456-oa6hh7ky	324	27	reversal	reversal	NN
cord-276456-oa6hh7ky	324	28	of	of	IN
cord-276456-oa6hh7ky	324	29	high	high	JJ
cord-276456-oa6hh7ky	324	30	membrane	membrane	NN
cord-276456-oa6hh7ky	324	31	curvature	curvature	NN
cord-276456-oa6hh7ky	324	32	.	.	.
cord-276456-oa6hh7ky	325	1	From	from	IN
cord-276456-oa6hh7ky	325	2	these	these	DT
cord-276456-oa6hh7ky	325	3	studies	study	NNS
cord-276456-oa6hh7ky	325	4	,	,	,
cord-276456-oa6hh7ky	325	5	performed	perform	VBN
cord-276456-oa6hh7ky	325	6	in	in	IN
cord-276456-oa6hh7ky	325	7	model	model	NN
cord-276456-oa6hh7ky	325	8	membranes	membrane	NNS
cord-276456-oa6hh7ky	325	9	,	,	,
cord-276456-oa6hh7ky	325	10	membrane	membrane	NN
cord-276456-oa6hh7ky	325	11	fission	fission	NN
cord-276456-oa6hh7ky	325	12	may	may	MD
cord-276456-oa6hh7ky	325	13	therefore	therefore	RB
cord-276456-oa6hh7ky	325	14	be	be	VB
cord-276456-oa6hh7ky	325	15	considered	consider	VBN
cord-276456-oa6hh7ky	325	16	to	to	TO
cord-276456-oa6hh7ky	325	17	be	be	VB
cord-276456-oa6hh7ky	325	18	a	a	DT
cord-276456-oa6hh7ky	325	19	stochastic	stochastic	JJ
cord-276456-oa6hh7ky	325	20	result	result	NN
cord-276456-oa6hh7ky	325	21	of	of	IN
cord-276456-oa6hh7ky	325	22	GTP	gtp	NN
cord-276456-oa6hh7ky	325	23	hydrolysis	hydrolysis	NN
cord-276456-oa6hh7ky	325	24	.	.	.
cord-276456-oa6hh7ky	326	1	133	133	CD
cord-276456-oa6hh7ky	326	2	,	,	,
cord-276456-oa6hh7ky	326	3	139	139	CD
cord-276456-oa6hh7ky	326	4	Studies	Studies	NNPS
cord-276456-oa6hh7ky	326	5	in	in	IN
cord-276456-oa6hh7ky	326	6	adrenal	adrenal	JJ
cord-276456-oa6hh7ky	326	7	chromaffin	chromaffin	NN
cord-276456-oa6hh7ky	326	8	cells	cell	NNS
cord-276456-oa6hh7ky	326	9	suggest	suggest	VBP
cord-276456-oa6hh7ky	326	10	that	that	IN
cord-276456-oa6hh7ky	326	11	Ectopic	ectopic	JJ
cord-276456-oa6hh7ky	326	12	expression	expression	NN
cord-276456-oa6hh7ky	326	13	can	can	MD
cord-276456-oa6hh7ky	326	14	reverse	reverse	VB
cord-276456-oa6hh7ky	326	15	the	the	DT
cord-276456-oa6hh7ky	326	16	otherwise	otherwise	RB
cord-276456-oa6hh7ky	326	17	lethal	lethal	JJ
cord-276456-oa6hh7ky	326	18	neurodegeneration	neurodegeneration	NN
cord-276456-oa6hh7ky	326	19	of	of	IN
cord-276456-oa6hh7ky	326	20	cysteine	cysteine	NN
cord-276456-oa6hh7ky	326	21	string	string	NN
cord-276456-oa6hh7ky	326	22	protein	protein	NN
cord-276456-oa6hh7ky	326	23	-	-	:
cord-276456-oa6hh7ky	326	24	a	a	DT
cord-276456-oa6hh7ky	326	25	knockout	knockout	NN
cord-276456-oa6hh7ky	326	26	mice	mice	NN
cord-276456-oa6hh7ky	326	27	.	.	.
cord-276456-oa6hh7ky	327	1	(	(	-LRB-
cord-276456-oa6hh7ky	327	2	123	123	CD
cord-276456-oa6hh7ky	327	3	,	,	,
cord-276456-oa6hh7ky	327	4	124	124	CD
cord-276456-oa6hh7ky	327	5	)	)	-RRB-
cord-276456-oa6hh7ky	327	6	dynamin	dynamin	NNP
cord-276456-oa6hh7ky	327	7	functions	function	NNS
cord-276456-oa6hh7ky	327	8	in	in	IN
cord-276456-oa6hh7ky	327	9	a	a	DT
cord-276456-oa6hh7ky	327	10	similar	similar	JJ
cord-276456-oa6hh7ky	327	11	way	way	NN
cord-276456-oa6hh7ky	327	12	to	to	TO
cord-276456-oa6hh7ky	327	13	control	control	VB
cord-276456-oa6hh7ky	327	14	the	the	DT
cord-276456-oa6hh7ky	327	15	fate	fate	NN
cord-276456-oa6hh7ky	327	16	of	of	IN
cord-276456-oa6hh7ky	327	17	a	a	DT
cord-276456-oa6hh7ky	327	18	recently	recently	RB
cord-276456-oa6hh7ky	327	19	fused	fuse	VBN
cord-276456-oa6hh7ky	327	20	secretory	secretory	JJ
cord-276456-oa6hh7ky	327	21	granule	granule	NN
cord-276456-oa6hh7ky	327	22	.	.	.
cord-276456-oa6hh7ky	328	1	Increasing	increase	VBG
cord-276456-oa6hh7ky	328	2	the	the	DT
cord-276456-oa6hh7ky	328	3	dynamin	dynamin	NN
cord-276456-oa6hh7ky	329	1	GTPase	GTPase	NNP
cord-276456-oa6hh7ky	329	2	activity	activity	NN
cord-276456-oa6hh7ky	329	3	increases	increase	VBZ
cord-276456-oa6hh7ky	329	4	the	the	DT
cord-276456-oa6hh7ky	329	5	rate	rate	NN
cord-276456-oa6hh7ky	329	6	of	of	IN
cord-276456-oa6hh7ky	329	7	fusion	fusion	NN
cord-276456-oa6hh7ky	329	8	pore	pore	NN
cord-276456-oa6hh7ky	329	9	expansion	expansion	NN
cord-276456-oa6hh7ky	329	10	and	and	CC
cord-276456-oa6hh7ky	329	11	the	the	DT
cord-276456-oa6hh7ky	329	12	likelihood	likelihood	NN
cord-276456-oa6hh7ky	329	13	of	of	IN
cord-276456-oa6hh7ky	329	14	rapid	rapid	JJ
cord-276456-oa6hh7ky	329	15	endocytosis	endocytosis	NN
cord-276456-oa6hh7ky	329	16	.	.	.
cord-276456-oa6hh7ky	330	1	138	138	CD
cord-276456-oa6hh7ky	331	1	The	the	DT
cord-276456-oa6hh7ky	331	2	results	result	NNS
cord-276456-oa6hh7ky	331	3	are	be	VBP
cord-276456-oa6hh7ky	331	4	consistent	consistent	JJ
cord-276456-oa6hh7ky	331	5	with	with	IN
cord-276456-oa6hh7ky	331	6	a	a	DT
cord-276456-oa6hh7ky	331	7	function	function	NN
cord-276456-oa6hh7ky	331	8	for	for	IN
cord-276456-oa6hh7ky	331	9	dynamin	dynamin	NN
cord-276456-oa6hh7ky	331	10	in	in	IN
cord-276456-oa6hh7ky	331	11	restricting	restrict	VBG
cord-276456-oa6hh7ky	331	12	fusion	fusion	NN
cord-276456-oa6hh7ky	331	13	pore	pore	NN
cord-276456-oa6hh7ky	331	14	expansion	expansion	NN
cord-276456-oa6hh7ky	331	15	.	.	.
cord-276456-oa6hh7ky	332	1	Increased	increase	VBN
cord-276456-oa6hh7ky	332	2	GTP	gtp	NN
cord-276456-oa6hh7ky	332	3	activity	activity	NN
cord-276456-oa6hh7ky	332	4	catalyzes	catalyze	VBZ
cord-276456-oa6hh7ky	332	5	a	a	DT
cord-276456-oa6hh7ky	332	6	more	more	RBR
cord-276456-oa6hh7ky	332	7	rapid	rapid	JJ
cord-276456-oa6hh7ky	332	8	stochastic	stochastic	JJ
cord-276456-oa6hh7ky	332	9	decision	decision	NN
cord-276456-oa6hh7ky	332	10	that	that	WDT
cord-276456-oa6hh7ky	332	11	results	result	VBZ
cord-276456-oa6hh7ky	332	12	in	in	IN
cord-276456-oa6hh7ky	332	13	either	either	DT
cord-276456-oa6hh7ky	332	14	fusion	fusion	NN
cord-276456-oa6hh7ky	332	15	pore	pore	NN
cord-276456-oa6hh7ky	332	16	expansion	expansion	NN
cord-276456-oa6hh7ky	332	17	or	or	CC
cord-276456-oa6hh7ky	332	18	(	(	-LRB-
cord-276456-oa6hh7ky	332	19	less	less	RBR
cord-276456-oa6hh7ky	332	20	frequently	frequently	RB
cord-276456-oa6hh7ky	332	21	)	)	-RRB-
cord-276456-oa6hh7ky	332	22	membrane	membrane	NN
cord-276456-oa6hh7ky	332	23	fission	fission	NN
cord-276456-oa6hh7ky	332	24	and	and	CC
cord-276456-oa6hh7ky	332	25	endocytosis	endocytosis	NN
cord-276456-oa6hh7ky	332	26	.	.	.
cord-276456-oa6hh7ky	333	1	Recent	recent	JJ
cord-276456-oa6hh7ky	333	2	theoretical	theoretical	JJ
cord-276456-oa6hh7ky	333	3	and	and	CC
cord-276456-oa6hh7ky	333	4	experimental	experimental	JJ
cord-276456-oa6hh7ky	333	5	studies	study	NNS
cord-276456-oa6hh7ky	333	6	of	of	IN
cord-276456-oa6hh7ky	333	7	membrane	membrane	NN
cord-276456-oa6hh7ky	333	8	fission	fission	NN
cord-276456-oa6hh7ky	333	9	by	by	IN
cord-276456-oa6hh7ky	333	10	dynamin	dynamin	NN
cord-276456-oa6hh7ky	333	11	and	and	CC
cord-276456-oa6hh7ky	333	12	viral	viral	JJ
cord-276456-oa6hh7ky	333	13	matrix	matrix	NN
cord-276456-oa6hh7ky	333	14	protein	protein	NN
cord-276456-oa6hh7ky	333	15	reveal	reveal	VBP
cord-276456-oa6hh7ky	333	16	how	how	WRB
cord-276456-oa6hh7ky	333	17	protein	protein	NN
cord-276456-oa6hh7ky	333	18	complexes	complex	NNS
cord-276456-oa6hh7ky	333	19	are	be	VBP
cord-276456-oa6hh7ky	333	20	arranged	arrange	VBN
cord-276456-oa6hh7ky	333	21	to	to	TO
cord-276456-oa6hh7ky	333	22	effectively	effectively	RB
cord-276456-oa6hh7ky	333	23	apply	apply	VB
cord-276456-oa6hh7ky	333	24	localized	localized	JJ
cord-276456-oa6hh7ky	333	25	curvature	curvature	NN
cord-276456-oa6hh7ky	333	26	stress	stress	NN
cord-276456-oa6hh7ky	333	27	to	to	IN
cord-276456-oa6hh7ky	333	28	membranes	membrane	NNS
cord-276456-oa6hh7ky	333	29	without	without	IN
cord-276456-oa6hh7ky	333	30	perturbing	perturb	VBG
cord-276456-oa6hh7ky	333	31	lateral	lateral	JJ
cord-276456-oa6hh7ky	333	32	membrane	membrane	NN
cord-276456-oa6hh7ky	333	33	integrity	integrity	NN
cord-276456-oa6hh7ky	333	34	;	;	:
cord-276456-oa6hh7ky	333	35	that	that	RB
cord-276456-oa6hh7ky	333	36	is	is	RB
cord-276456-oa6hh7ky	333	37	,	,	,
cord-276456-oa6hh7ky	333	38	without	without	IN
cord-276456-oa6hh7ky	333	39	leakage	leakage	NN
cord-276456-oa6hh7ky	333	40	.	.	.
cord-276456-oa6hh7ky	334	1	One	one	CD
cord-276456-oa6hh7ky	334	2	conceptual	conceptual	JJ
cord-276456-oa6hh7ky	334	3	approach	approach	NN
cord-276456-oa6hh7ky	334	4	is	be	VBZ
cord-276456-oa6hh7ky	334	5	that	that	IN
cord-276456-oa6hh7ky	334	6	sites	site	NNS
cord-276456-oa6hh7ky	334	7	of	of	IN
cord-276456-oa6hh7ky	334	8	membrane	membrane	NN
cord-276456-oa6hh7ky	334	9	remodeling	remodeling	NN
cord-276456-oa6hh7ky	334	10	are	be	VBP
cord-276456-oa6hh7ky	334	11	organized	organize	VBN
cord-276456-oa6hh7ky	334	12	as	as	IN
cord-276456-oa6hh7ky	334	13	membrane	membrane	NN
cord-276456-oa6hh7ky	334	14	domains	domain	NNS
cord-276456-oa6hh7ky	334	15	,	,	,
cord-276456-oa6hh7ky	334	16	both	both	CC
cord-276456-oa6hh7ky	334	17	through	through	IN
cord-276456-oa6hh7ky	334	18	membrane	membrane	NN
cord-276456-oa6hh7ky	334	19	composition	composition	NN
cord-276456-oa6hh7ky	334	20	and	and	CC
cord-276456-oa6hh7ky	334	21	membrane	membrane	NN
cord-276456-oa6hh7ky	334	22	curvature	curvature	NN
cord-276456-oa6hh7ky	334	23	;	;	:
cord-276456-oa6hh7ky	334	24	thus	thus	RB
cord-276456-oa6hh7ky	334	25	membrane	membrane	NN
cord-276456-oa6hh7ky	334	26	remodeling	remodeling	NN
cord-276456-oa6hh7ky	334	27	is	be	VBZ
cord-276456-oa6hh7ky	334	28	a	a	DT
cord-276456-oa6hh7ky	334	29	collaborative	collaborative	JJ
cord-276456-oa6hh7ky	334	30	effort	effort	NN
cord-276456-oa6hh7ky	334	31	accomplished	accomplish	VBN
cord-276456-oa6hh7ky	334	32	by	by	IN
cord-276456-oa6hh7ky	334	33	the	the	DT
cord-276456-oa6hh7ky	334	34	entire	entire	JJ
cord-276456-oa6hh7ky	334	35	domain	domain	NN
cord-276456-oa6hh7ky	334	36	,	,	,
cord-276456-oa6hh7ky	334	37	involving	involve	VBG
cord-276456-oa6hh7ky	334	38	protein	protein	NN
cord-276456-oa6hh7ky	334	39	complexes	complex	NNS
cord-276456-oa6hh7ky	334	40	and	and	CC
cord-276456-oa6hh7ky	334	41	multiple	multiple	JJ
cord-276456-oa6hh7ky	334	42	lipids	lipid	NNS
cord-276456-oa6hh7ky	334	43	.	.	.
cord-276456-oa6hh7ky	335	1	We	-PRON-	PRP
cord-276456-oa6hh7ky	335	2	emphasize	emphasize	VBP
cord-276456-oa6hh7ky	335	3	that	that	IN
cord-276456-oa6hh7ky	335	4	despite	despite	IN
cord-276456-oa6hh7ky	335	5	decades	decade	NNS
cord-276456-oa6hh7ky	335	6	of	of	IN
cord-276456-oa6hh7ky	335	7	studies	study	NNS
cord-276456-oa6hh7ky	335	8	we	-PRON-	PRP
cord-276456-oa6hh7ky	335	9	still	still	RB
cord-276456-oa6hh7ky	335	10	know	know	VBP
cord-276456-oa6hh7ky	335	11	only	only	RB
cord-276456-oa6hh7ky	335	12	a	a	DT
cord-276456-oa6hh7ky	335	13	little	little	JJ
cord-276456-oa6hh7ky	335	14	about	about	IN
cord-276456-oa6hh7ky	335	15	fundamental	fundamental	JJ
cord-276456-oa6hh7ky	335	16	physical	physical	JJ
cord-276456-oa6hh7ky	335	17	principles	principle	NNS
cord-276456-oa6hh7ky	335	18	underlying	underlie	VBG
cord-276456-oa6hh7ky	335	19	the	the	DT
cord-276456-oa6hh7ky	335	20	spatial	spatial	JJ
cord-276456-oa6hh7ky	335	21	and	and	CC
cord-276456-oa6hh7ky	335	22	temporal	temporal	JJ
cord-276456-oa6hh7ky	335	23	organization	organization	NN
cord-276456-oa6hh7ky	335	24	of	of	IN
cord-276456-oa6hh7ky	335	25	membrane	membrane	NN
cord-276456-oa6hh7ky	335	26	domains	domain	NNS
cord-276456-oa6hh7ky	335	27	specialized	specialize	VBN
cord-276456-oa6hh7ky	335	28	in	in	IN
cord-276456-oa6hh7ky	335	29	membrane	membrane	NN
cord-276456-oa6hh7ky	335	30	remodeling	remodeling	NN
cord-276456-oa6hh7ky	335	31	.	.	.
cord-276456-oa6hh7ky	336	1	For	for	IN
cord-276456-oa6hh7ky	336	2	example	example	NN
cord-276456-oa6hh7ky	336	3	,	,	,
cord-276456-oa6hh7ky	336	4	the	the	DT
cord-276456-oa6hh7ky	336	5	structure	structure	NN
cord-276456-oa6hh7ky	336	6	and	and	CC
cord-276456-oa6hh7ky	336	7	composition	composition	NN
cord-276456-oa6hh7ky	336	8	of	of	IN
cord-276456-oa6hh7ky	336	9	the	the	DT
cord-276456-oa6hh7ky	336	10	fusion	fusion	NN
cord-276456-oa6hh7ky	336	11	pore	pore	NN
cord-276456-oa6hh7ky	336	12	are	be	VBP
cord-276456-oa6hh7ky	336	13	unknown	unknown	JJ
cord-276456-oa6hh7ky	336	14	.	.	.
cord-276456-oa6hh7ky	337	1	New	new	JJ
cord-276456-oa6hh7ky	337	2	synergistic	synergistic	JJ
cord-276456-oa6hh7ky	337	3	experimental	experimental	JJ
cord-276456-oa6hh7ky	337	4	and	and	CC
cord-276456-oa6hh7ky	337	5	theoretical	theoretical	JJ
cord-276456-oa6hh7ky	337	6	approaches	approach	NNS
cord-276456-oa6hh7ky	337	7	are	be	VBP
cord-276456-oa6hh7ky	337	8	needed	need	VBN
cord-276456-oa6hh7ky	337	9	to	to	TO
cord-276456-oa6hh7ky	337	10	resolve	resolve	VB
cord-276456-oa6hh7ky	337	11	how	how	WRB
cord-276456-oa6hh7ky	337	12	proteins	protein	NNS
cord-276456-oa6hh7ky	337	13	merge	merge	VBP
cord-276456-oa6hh7ky	337	14	and	and	CC
cord-276456-oa6hh7ky	337	15	separate	separate	JJ
cord-276456-oa6hh7ky	337	16	membranes	membrane	NNS
cord-276456-oa6hh7ky	337	17	.	.	.
cord-276456-oa6hh7ky	338	1	For	for	IN
cord-276456-oa6hh7ky	338	2	example	example	NN
cord-276456-oa6hh7ky	338	3	,	,	,
cord-276456-oa6hh7ky	338	4	the	the	DT
cord-276456-oa6hh7ky	338	5	ability	ability	NN
cord-276456-oa6hh7ky	338	6	to	to	TO
cord-276456-oa6hh7ky	338	7	detect	detect	VB
cord-276456-oa6hh7ky	338	8	submicron	submicron	JJ
cord-276456-oa6hh7ky	338	9	deformations	deformation	NNS
cord-276456-oa6hh7ky	338	10	of	of	IN
cord-276456-oa6hh7ky	338	11	the	the	DT
cord-276456-oa6hh7ky	338	12	plasma	plasma	NN
cord-276456-oa6hh7ky	338	13	membrane	membrane	NN
cord-276456-oa6hh7ky	338	14	with	with	IN
cord-276456-oa6hh7ky	338	15	the	the	DT
cord-276456-oa6hh7ky	338	16	combination	combination	NN
cord-276456-oa6hh7ky	338	17	of	of	IN
cord-276456-oa6hh7ky	338	18	polarization	polarization	NN
cord-276456-oa6hh7ky	338	19	and	and	CC
cord-276456-oa6hh7ky	338	20	TIRFM	TIRFM	NNP
cord-276456-oa6hh7ky	338	21	techniques	technique	NNS
cord-276456-oa6hh7ky	338	22	138	138	CD
cord-276456-oa6hh7ky	338	23	,	,	,
cord-276456-oa6hh7ky	338	24	139	139	CD
cord-276456-oa6hh7ky	338	25	permits	permit	VBZ
cord-276456-oa6hh7ky	338	26	detection	detection	NN
cord-276456-oa6hh7ky	338	27	of	of	IN
cord-276456-oa6hh7ky	338	28	the	the	DT
cord-276456-oa6hh7ky	338	29	expanding	expand	VBG
cord-276456-oa6hh7ky	338	30	fusion	fusion	NN
cord-276456-oa6hh7ky	338	31	pore	pore	NN
cord-276456-oa6hh7ky	338	32	and	and	CC
cord-276456-oa6hh7ky	338	33	may	may	MD
cord-276456-oa6hh7ky	338	34	enable	enable	VB
cord-276456-oa6hh7ky	338	35	investigations	investigation	NNS
cord-276456-oa6hh7ky	338	36	of	of	IN
cord-276456-oa6hh7ky	338	37	the	the	DT
cord-276456-oa6hh7ky	338	38	molecular	molecular	JJ
cord-276456-oa6hh7ky	338	39	basis	basis	NN
cord-276456-oa6hh7ky	338	40	for	for	IN
cord-276456-oa6hh7ky	338	41	membrane	membrane	NN
cord-276456-oa6hh7ky	338	42	curvature	curvature	NN
cord-276456-oa6hh7ky	338	43	changes	change	NNS
cord-276456-oa6hh7ky	338	44	in	in	IN
cord-276456-oa6hh7ky	338	45	living	living	NN
cord-276456-oa6hh7ky	338	46	cells	cell	NNS
cord-276456-oa6hh7ky	338	47	.	.	.
cord-276456-oa6hh7ky	339	1	The	the	DT
cord-276456-oa6hh7ky	339	2	key	key	NN
cord-276456-oa6hh7ky	339	3	is	be	VBZ
cord-276456-oa6hh7ky	339	4	to	to	TO
cord-276456-oa6hh7ky	339	5	study	study	VB
cord-276456-oa6hh7ky	339	6	membrane	membrane	NN
cord-276456-oa6hh7ky	339	7	remodeling	remodeling	NN
cord-276456-oa6hh7ky	339	8	in	in	IN
cord-276456-oa6hh7ky	339	9	the	the	DT
cord-276456-oa6hh7ky	339	10	context	context	NN
cord-276456-oa6hh7ky	339	11	of	of	IN
cord-276456-oa6hh7ky	339	12	concrete	concrete	JJ
cord-276456-oa6hh7ky	339	13	biological	biological	JJ
cord-276456-oa6hh7ky	339	14	processes	process	NNS
cord-276456-oa6hh7ky	339	15	,	,	,
cord-276456-oa6hh7ky	339	16	taking	take	VBG
cord-276456-oa6hh7ky	339	17	into	into	IN
cord-276456-oa6hh7ky	339	18	account	account	NN
cord-276456-oa6hh7ky	339	19	corresponding	correspond	VBG
cord-276456-oa6hh7ky	339	20	length	length	NN
cord-276456-oa6hh7ky	339	21	scales	scale	NNS
cord-276456-oa6hh7ky	339	22	for	for	IN
cord-276456-oa6hh7ky	339	23	the	the	DT
cord-276456-oa6hh7ky	339	24	key	key	JJ
cord-276456-oa6hh7ky	339	25	membrane	membrane	NN
cord-276456-oa6hh7ky	339	26	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	339	27	,	,	,
cord-276456-oa6hh7ky	339	28	dynamic	dynamic	JJ
cord-276456-oa6hh7ky	339	29	cooperation	cooperation	NN
cord-276456-oa6hh7ky	339	30	between	between	IN
cord-276456-oa6hh7ky	339	31	protein	protein	NN
cord-276456-oa6hh7ky	339	32	machineries	machinery	NNS
cord-276456-oa6hh7ky	339	33	and	and	CC
cord-276456-oa6hh7ky	339	34	lipids	lipid	NNS
cord-276456-oa6hh7ky	339	35	,	,	,
cord-276456-oa6hh7ky	339	36	component	component	NN
cord-276456-oa6hh7ky	339	37	segregation	segregation	NN
cord-276456-oa6hh7ky	339	38	and	and	CC
cord-276456-oa6hh7ky	339	39	sorting	sorting	NN
cord-276456-oa6hh7ky	339	40	and	and	CC
cord-276456-oa6hh7ky	339	41	,	,	,
cord-276456-oa6hh7ky	339	42	importantly	importantly	RB
cord-276456-oa6hh7ky	339	43	,	,	,
cord-276456-oa6hh7ky	339	44	longrange	longrange	JJ
cord-276456-oa6hh7ky	339	45	interactions	interaction	NNS
cord-276456-oa6hh7ky	339	46	which	which	WDT
cord-276456-oa6hh7ky	339	47	are	be	VBP
cord-276456-oa6hh7ky	339	48	,	,	,
cord-276456-oa6hh7ky	339	49	ultimately	ultimately	RB
cord-276456-oa6hh7ky	339	50	,	,	,
cord-276456-oa6hh7ky	339	51	of	of	IN
cord-276456-oa6hh7ky	339	52	critical	critical	JJ
cord-276456-oa6hh7ky	339	53	importance	importance	NN
cord-276456-oa6hh7ky	339	54	for	for	IN
cord-276456-oa6hh7ky	339	55	highly	highly	RB
cord-276456-oa6hh7ky	339	56	localized	localize	VBN
cord-276456-oa6hh7ky	339	57	membrane	membrane	NN
cord-276456-oa6hh7ky	339	58	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	339	59	leading	lead	VBG
cord-276456-oa6hh7ky	339	60	to	to	IN
cord-276456-oa6hh7ky	339	61	membrane	membrane	NN
cord-276456-oa6hh7ky	339	62	fusion	fusion	NN
cord-276456-oa6hh7ky	339	63	or	or	CC
cord-276456-oa6hh7ky	339	64	fission	fission	NN
cord-276456-oa6hh7ky	339	65	.	.	.
cord-276456-oa6hh7ky	340	1	Functional	functional	JJ
cord-276456-oa6hh7ky	340	2	determinants	determinant	NNS
cord-276456-oa6hh7ky	340	3	of	of	IN
cord-276456-oa6hh7ky	340	4	a	a	DT
cord-276456-oa6hh7ky	340	5	synthetic	synthetic	JJ
cord-276456-oa6hh7ky	340	6	vesicle	vesicle	NN
cord-276456-oa6hh7ky	340	7	fusion	fusion	NN
cord-276456-oa6hh7ky	340	8	system	system	NN
cord-276456-oa6hh7ky	340	9	Influence	influence	NN
cord-276456-oa6hh7ky	340	10	of	of	IN
cord-276456-oa6hh7ky	340	11	lipid	lipid	NN
cord-276456-oa6hh7ky	340	12	composition	composition	NN
cord-276456-oa6hh7ky	340	13	on	on	IN
cord-276456-oa6hh7ky	340	14	physical	physical	JJ
cord-276456-oa6hh7ky	340	15	properties	property	NNS
cord-276456-oa6hh7ky	340	16	and	and	CC
cord-276456-oa6hh7ky	340	17	peg	peg	NN
cord-276456-oa6hh7ky	340	18	-	-	HYPH
cord-276456-oa6hh7ky	340	19	mediated	mediate	VBN
cord-276456-oa6hh7ky	340	20	fusion	fusion	NN
cord-276456-oa6hh7ky	340	21	of	of	IN
cord-276456-oa6hh7ky	340	22	curved	curved	JJ
cord-276456-oa6hh7ky	340	23	and	and	CC
cord-276456-oa6hh7ky	340	24	uncurved	uncurved	JJ
cord-276456-oa6hh7ky	340	25	model	model	NN
cord-276456-oa6hh7ky	340	26	membrane	membrane	NN
cord-276456-oa6hh7ky	340	27	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	340	28	:	:	:
cord-276456-oa6hh7ky	340	29	'	'	''
cord-276456-oa6hh7ky	340	30	'	'	``
cord-276456-oa6hh7ky	340	31	nature	nature	NN
cord-276456-oa6hh7ky	340	32	'	'	''
cord-276456-oa6hh7ky	340	33	s	s	POS
cord-276456-oa6hh7ky	340	34	own	own	JJ
cord-276456-oa6hh7ky	340	35	'	'	''
cord-276456-oa6hh7ky	340	36	'	'	``
cord-276456-oa6hh7ky	340	37	fusogenic	fusogenic	JJ
cord-276456-oa6hh7ky	340	38	lipid	lipid	NN
cord-276456-oa6hh7ky	340	39	bilayer	bilayer	NN
cord-276456-oa6hh7ky	340	40	Fusion	fusion	NN
cord-276456-oa6hh7ky	340	41	pores	pore	NNS
cord-276456-oa6hh7ky	340	42	and	and	CC
cord-276456-oa6hh7ky	340	43	fusion	fusion	NN
cord-276456-oa6hh7ky	340	44	machines	machine	NNS
cord-276456-oa6hh7ky	340	45	in	in	IN
cord-276456-oa6hh7ky	340	46	Ca	Ca	NNP
cord-276456-oa6hh7ky	340	47	2	2	CD
cord-276456-oa6hh7ky	340	48	+	+	.
cord-276456-oa6hh7ky	341	1	-triggered	-triggered	CD
cord-276456-oa6hh7ky	341	2	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	342	1	The	the	DT
cord-276456-oa6hh7ky	342	2	molecular	molecular	JJ
cord-276456-oa6hh7ky	342	3	mechanism	mechanism	NN
cord-276456-oa6hh7ky	342	4	of	of	IN
cord-276456-oa6hh7ky	342	5	mitochondrial	mitochondrial	JJ
cord-276456-oa6hh7ky	342	6	fusion	fusion	NN
cord-276456-oa6hh7ky	342	7	Mitochondrial	mitochondrial	JJ
cord-276456-oa6hh7ky	342	8	fusion	fusion	NN
cord-276456-oa6hh7ky	342	9	and	and	CC
cord-276456-oa6hh7ky	342	10	fission	fission	NN
cord-276456-oa6hh7ky	342	11	in	in	IN
cord-276456-oa6hh7ky	342	12	mammals	mammal	NNS
cord-276456-oa6hh7ky	342	13	Protein	protein	NN
cord-276456-oa6hh7ky	342	14	-	-	HYPH
cord-276456-oa6hh7ky	342	15	driven	drive	VBN
cord-276456-oa6hh7ky	342	16	membrane	membrane	NN
cord-276456-oa6hh7ky	342	17	stresses	stress	NNS
cord-276456-oa6hh7ky	342	18	in	in	IN
cord-276456-oa6hh7ky	342	19	fusion	fusion	NN
cord-276456-oa6hh7ky	342	20	and	and	CC
cord-276456-oa6hh7ky	342	21	fission	fission	NN
cord-276456-oa6hh7ky	342	22	Protein	protein	NN
cord-276456-oa6hh7ky	342	23	-	-	HYPH
cord-276456-oa6hh7ky	342	24	lipid	lipid	NN
cord-276456-oa6hh7ky	342	25	interplay	interplay	NN
cord-276456-oa6hh7ky	342	26	in	in	IN
cord-276456-oa6hh7ky	342	27	fusion	fusion	NN
cord-276456-oa6hh7ky	342	28	and	and	CC
cord-276456-oa6hh7ky	342	29	fission	fission	NN
cord-276456-oa6hh7ky	342	30	of	of	IN
cord-276456-oa6hh7ky	342	31	biological	biological	JJ
cord-276456-oa6hh7ky	342	32	membranes	membrane	NNS
cord-276456-oa6hh7ky	342	33	Mechanisms	Mechanisms	NNPS
cord-276456-oa6hh7ky	342	34	of	of	IN
cord-276456-oa6hh7ky	342	35	membrane	membrane	NN
cord-276456-oa6hh7ky	342	36	fusion	fusion	NN
cord-276456-oa6hh7ky	342	37	:	:	:
cord-276456-oa6hh7ky	342	38	disparate	disparate	JJ
cord-276456-oa6hh7ky	342	39	players	player	NNS
cord-276456-oa6hh7ky	342	40	and	and	CC
cord-276456-oa6hh7ky	342	41	common	common	JJ
cord-276456-oa6hh7ky	342	42	principles	principle	NNS
cord-276456-oa6hh7ky	343	1	Conflicting	conflict	VBG
cord-276456-oa6hh7ky	343	2	views	view	NNS
cord-276456-oa6hh7ky	343	3	on	on	IN
cord-276456-oa6hh7ky	343	4	the	the	DT
cord-276456-oa6hh7ky	343	5	membrane	membrane	NN
cord-276456-oa6hh7ky	343	6	fusion	fusion	NN
cord-276456-oa6hh7ky	343	7	machinery	machinery	NN
cord-276456-oa6hh7ky	343	8	and	and	CC
cord-276456-oa6hh7ky	343	9	the	the	DT
cord-276456-oa6hh7ky	343	10	fusion	fusion	NN
cord-276456-oa6hh7ky	343	11	pore	pore	NN
cord-276456-oa6hh7ky	344	1	How	how	WRB
cord-276456-oa6hh7ky	344	2	does	do	VBZ
cord-276456-oa6hh7ky	344	3	synaptotagmin	synaptotagmin	JJ
cord-276456-oa6hh7ky	344	4	trigger	trigger	NN
cord-276456-oa6hh7ky	344	5	neurotransmitter	neurotransmitter	NN
cord-276456-oa6hh7ky	344	6	release	release	NN
cord-276456-oa6hh7ky	344	7	?	?	.
cord-276456-oa6hh7ky	345	1	Flickering	flicker	VBG
cord-276456-oa6hh7ky	345	2	fusion	fusion	NN
cord-276456-oa6hh7ky	345	3	pores	pore	NNS
cord-276456-oa6hh7ky	345	4	comparable	comparable	JJ
cord-276456-oa6hh7ky	345	5	with	with	IN
cord-276456-oa6hh7ky	345	6	initial	initial	JJ
cord-276456-oa6hh7ky	345	7	exocytotic	exocytotic	JJ
cord-276456-oa6hh7ky	345	8	pores	pore	NNS
cord-276456-oa6hh7ky	345	9	occur	occur	VBP
cord-276456-oa6hh7ky	345	10	in	in	IN
cord-276456-oa6hh7ky	345	11	protein	protein	NN
cord-276456-oa6hh7ky	345	12	-	-	HYPH
cord-276456-oa6hh7ky	345	13	free	free	JJ
cord-276456-oa6hh7ky	345	14	phospholipid	phospholipid	NN
cord-276456-oa6hh7ky	345	15	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	346	1	GPI	GPI	NNP
cord-276456-oa6hh7ky	346	2	-	-	HYPH
cord-276456-oa6hh7ky	346	3	anchored	anchor	VBN
cord-276456-oa6hh7ky	346	4	influenza	influenza	NN
cord-276456-oa6hh7ky	346	5	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	346	6	induces	induce	VBZ
cord-276456-oa6hh7ky	346	7	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	346	8	to	to	IN
cord-276456-oa6hh7ky	346	9	both	both	DT
cord-276456-oa6hh7ky	346	10	red	red	JJ
cord-276456-oa6hh7ky	346	11	blood	blood	NN
cord-276456-oa6hh7ky	346	12	cell	cell	NN
cord-276456-oa6hh7ky	346	13	and	and	CC
cord-276456-oa6hh7ky	346	14	planar	planar	JJ
cord-276456-oa6hh7ky	346	15	bilayer	bilayer	NN
cord-276456-oa6hh7ky	346	16	membranes	membrane	NNS
cord-276456-oa6hh7ky	347	1	The	the	DT
cord-276456-oa6hh7ky	347	2	pathway	pathway	NN
cord-276456-oa6hh7ky	347	3	of	of	IN
cord-276456-oa6hh7ky	347	4	membrane	membrane	NN
cord-276456-oa6hh7ky	347	5	fusion	fusion	NN
cord-276456-oa6hh7ky	347	6	catalyzed	catalyze	VBN
cord-276456-oa6hh7ky	347	7	by	by	IN
cord-276456-oa6hh7ky	347	8	influenza	influenza	NN
cord-276456-oa6hh7ky	347	9	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	347	10	:	:	:
cord-276456-oa6hh7ky	347	11	restriction	restriction	NN
cord-276456-oa6hh7ky	347	12	of	of	IN
cord-276456-oa6hh7ky	347	13	lipids	lipid	NNS
cord-276456-oa6hh7ky	347	14	,	,	,
cord-276456-oa6hh7ky	347	15	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	347	16	,	,	,
cord-276456-oa6hh7ky	347	17	and	and	CC
cord-276456-oa6hh7ky	347	18	lipidic	lipidic	NNP
cord-276456-oa6hh7ky	347	19	fusion	fusion	NN
cord-276456-oa6hh7ky	347	20	pore	pore	NN
cord-276456-oa6hh7ky	347	21	formation	formation	NN
cord-276456-oa6hh7ky	348	1	Possible	possible	JJ
cord-276456-oa6hh7ky	348	2	mechanism	mechanism	NN
cord-276456-oa6hh7ky	348	3	of	of	IN
cord-276456-oa6hh7ky	348	4	membrane	membrane	NN
cord-276456-oa6hh7ky	348	5	fusion	fusion	NN
cord-276456-oa6hh7ky	348	6	Phospholipid	phospholipid	NN
cord-276456-oa6hh7ky	348	7	surface	surface	NN
cord-276456-oa6hh7ky	348	8	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	348	9	at	at	IN
cord-276456-oa6hh7ky	348	10	the	the	DT
cord-276456-oa6hh7ky	348	11	air	air	NN
cord-276456-oa6hh7ky	348	12	-	-	HYPH
cord-276456-oa6hh7ky	348	13	water	water	NN
cord-276456-oa6hh7ky	348	14	interface	interface	NN
cord-276456-oa6hh7ky	348	15	.	.	.
cord-276456-oa6hh7ky	349	1	II	II	NNP
cord-276456-oa6hh7ky	349	2	.	.	.
cord-276456-oa6hh7ky	350	1	Water	water	NN
cord-276456-oa6hh7ky	350	2	permeability	permeability	NN
cord-276456-oa6hh7ky	350	3	of	of	IN
cord-276456-oa6hh7ky	350	4	dimyristoylphosphatidylcholine	dimyristoylphosphatidylcholine	NN
cord-276456-oa6hh7ky	350	5	surface	surface	NN
cord-276456-oa6hh7ky	350	6	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	350	7	On	on	IN
cord-276456-oa6hh7ky	350	8	the	the	DT
cord-276456-oa6hh7ky	350	9	theory	theory	NN
cord-276456-oa6hh7ky	350	10	of	of	IN
cord-276456-oa6hh7ky	350	11	membrane	membrane	NN
cord-276456-oa6hh7ky	350	12	fusion	fusion	NN
cord-276456-oa6hh7ky	350	13	.	.	.
cord-276456-oa6hh7ky	351	1	The	the	DT
cord-276456-oa6hh7ky	351	2	stalk	stalk	NN
cord-276456-oa6hh7ky	351	3	mechanism	mechanism	NN
cord-276456-oa6hh7ky	351	4	Asymmetric	asymmetric	JJ
cord-276456-oa6hh7ky	351	5	membranes	membrane	NNS
cord-276456-oa6hh7ky	351	6	resulting	result	VBG
cord-276456-oa6hh7ky	351	7	from	from	IN
cord-276456-oa6hh7ky	351	8	the	the	DT
cord-276456-oa6hh7ky	351	9	fusion	fusion	NN
cord-276456-oa6hh7ky	351	10	of	of	IN
cord-276456-oa6hh7ky	351	11	two	two	CD
cord-276456-oa6hh7ky	351	12	black	black	JJ
cord-276456-oa6hh7ky	351	13	lipid	lipid	NN
cord-276456-oa6hh7ky	351	14	bilayers	bilayer	VBZ
cord-276456-oa6hh7ky	351	15	Short	short	JJ
cord-276456-oa6hh7ky	351	16	-	-	HYPH
cord-276456-oa6hh7ky	351	17	chain	chain	NN
cord-276456-oa6hh7ky	351	18	alcohols	alcohol	NNS
cord-276456-oa6hh7ky	351	19	promote	promote	VBP
cord-276456-oa6hh7ky	351	20	an	an	DT
cord-276456-oa6hh7ky	351	21	early	early	JJ
cord-276456-oa6hh7ky	351	22	stage	stage	NN
cord-276456-oa6hh7ky	351	23	of	of	IN
cord-276456-oa6hh7ky	351	24	membrane	membrane	NN
cord-276456-oa6hh7ky	351	25	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	352	1	The	the	DT
cord-276456-oa6hh7ky	352	2	mechanisms	mechanism	NNS
cord-276456-oa6hh7ky	352	3	of	of	IN
cord-276456-oa6hh7ky	352	4	lipid	lipid	NN
cord-276456-oa6hh7ky	352	5	-	-	HYPH
cord-276456-oa6hh7ky	352	6	protein	protein	NN
cord-276456-oa6hh7ky	352	7	rearrangements	rearrangement	NNS
cord-276456-oa6hh7ky	352	8	during	during	IN
cord-276456-oa6hh7ky	352	9	viral	viral	JJ
cord-276456-oa6hh7ky	352	10	infection	infection	NN
cord-276456-oa6hh7ky	352	11	How	how	WRB
cord-276456-oa6hh7ky	352	12	proteins	protein	NNS
cord-276456-oa6hh7ky	352	13	produce	produce	VBP
cord-276456-oa6hh7ky	352	14	cellular	cellular	JJ
cord-276456-oa6hh7ky	352	15	membrane	membrane	NN
cord-276456-oa6hh7ky	352	16	curvature	curvature	NN
cord-276456-oa6hh7ky	352	17	Lipids	lipid	NNS
cord-276456-oa6hh7ky	352	18	in	in	IN
cord-276456-oa6hh7ky	352	19	biological	biological	JJ
cord-276456-oa6hh7ky	352	20	membrane	membrane	NN
cord-276456-oa6hh7ky	352	21	fusion	fusion	NN
cord-276456-oa6hh7ky	352	22	Intrinsic	intrinsic	JJ
cord-276456-oa6hh7ky	352	23	bending	bend	VBG
cord-276456-oa6hh7ky	352	24	force	force	NN
cord-276456-oa6hh7ky	352	25	in	in	IN
cord-276456-oa6hh7ky	352	26	anisotropic	anisotropic	JJ
cord-276456-oa6hh7ky	352	27	membranes	membrane	NNS
cord-276456-oa6hh7ky	352	28	made	make	VBN
cord-276456-oa6hh7ky	352	29	of	of	IN
cord-276456-oa6hh7ky	352	30	chiral	chiral	JJ
cord-276456-oa6hh7ky	352	31	molecules	molecule	NNS
cord-276456-oa6hh7ky	352	32	Parameters	parameter	NNS
cord-276456-oa6hh7ky	352	33	affecting	affect	VBG
cord-276456-oa6hh7ky	352	34	the	the	DT
cord-276456-oa6hh7ky	352	35	fusion	fusion	NN
cord-276456-oa6hh7ky	352	36	of	of	IN
cord-276456-oa6hh7ky	352	37	unilamellar	unilamellar	JJ
cord-276456-oa6hh7ky	352	38	phospholipid	phospholipid	NN
cord-276456-oa6hh7ky	352	39	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	352	40	with	with	IN
cord-276456-oa6hh7ky	352	41	planar	planar	JJ
cord-276456-oa6hh7ky	352	42	bilayer	bilayer	NN
cord-276456-oa6hh7ky	352	43	membranes	membrane	VBZ
cord-276456-oa6hh7ky	352	44	A	a	DT
cord-276456-oa6hh7ky	352	45	quantitative	quantitative	JJ
cord-276456-oa6hh7ky	352	46	model	model	NN
cord-276456-oa6hh7ky	352	47	for	for	IN
cord-276456-oa6hh7ky	352	48	membrane	membrane	NN
cord-276456-oa6hh7ky	352	49	fusion	fusion	NN
cord-276456-oa6hh7ky	352	50	based	base	VBN
cord-276456-oa6hh7ky	352	51	on	on	IN
cord-276456-oa6hh7ky	352	52	low	low	JJ
cord-276456-oa6hh7ky	352	53	-	-	HYPH
cord-276456-oa6hh7ky	352	54	energy	energy	NN
cord-276456-oa6hh7ky	352	55	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	353	1	The	the	DT
cord-276456-oa6hh7ky	353	2	exocytotic	exocytotic	JJ
cord-276456-oa6hh7ky	353	3	fusion	fusion	NN
cord-276456-oa6hh7ky	353	4	pore	pore	NN
cord-276456-oa6hh7ky	353	5	modeled	model	VBN
cord-276456-oa6hh7ky	353	6	as	as	IN
cord-276456-oa6hh7ky	353	7	a	a	DT
cord-276456-oa6hh7ky	353	8	lipidic	lipidic	JJ
cord-276456-oa6hh7ky	353	9	pore	pore	NN
cord-276456-oa6hh7ky	353	10	Calcium	calcium	NN
cord-276456-oa6hh7ky	353	11	in	in	IN
cord-276456-oa6hh7ky	353	12	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	353	13	transmission	transmission	NN
cord-276456-oa6hh7ky	353	14	Timing	timing	NN
cord-276456-oa6hh7ky	353	15	of	of	IN
cord-276456-oa6hh7ky	353	16	neurotransmission	neurotransmission	NN
cord-276456-oa6hh7ky	353	17	at	at	IN
cord-276456-oa6hh7ky	353	18	fast	fast	JJ
cord-276456-oa6hh7ky	353	19	synapses	synapsis	NNS
cord-276456-oa6hh7ky	353	20	in	in	IN
cord-276456-oa6hh7ky	353	21	the	the	DT
cord-276456-oa6hh7ky	353	22	mammalian	mammalian	JJ
cord-276456-oa6hh7ky	353	23	brain	brain	NN
cord-276456-oa6hh7ky	353	24	Emerging	emerge	VBG
cord-276456-oa6hh7ky	353	25	roles	role	NNS
cord-276456-oa6hh7ky	353	26	of	of	IN
cord-276456-oa6hh7ky	353	27	presynaptic	presynaptic	JJ
cord-276456-oa6hh7ky	353	28	proteins	protein	NNS
cord-276456-oa6hh7ky	353	29	in	in	IN
cord-276456-oa6hh7ky	353	30	Ca	Ca	NNP
cord-276456-oa6hh7ky	353	31	þ	þ	NNP
cord-276456-oa6hh7ky	353	32	þtriggered	þtriggere	VBN
cord-276456-oa6hh7ky	353	33	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	354	1	How	how	WRB
cord-276456-oa6hh7ky	354	2	synaptotagmin	synaptotagmin	NNP
cord-276456-oa6hh7ky	354	3	promotes	promote	VBZ
cord-276456-oa6hh7ky	354	4	membrane	membrane	NN
cord-276456-oa6hh7ky	354	5	fusion	fusion	NN
cord-276456-oa6hh7ky	354	6	Evidence	evidence	NN
cord-276456-oa6hh7ky	354	7	that	that	IN
cord-276456-oa6hh7ky	354	8	the	the	DT
cord-276456-oa6hh7ky	354	9	inositol	inositol	NN
cord-276456-oa6hh7ky	354	10	phospholipids	phospholipid	NNS
cord-276456-oa6hh7ky	354	11	are	be	VBP
cord-276456-oa6hh7ky	354	12	necessary	necessary	JJ
cord-276456-oa6hh7ky	354	13	for	for	IN
cord-276456-oa6hh7ky	354	14	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	354	15	.	.	.
cord-276456-oa6hh7ky	355	1	Loss	loss	NN
cord-276456-oa6hh7ky	355	2	of	of	IN
cord-276456-oa6hh7ky	355	3	inositol	inositol	NN
cord-276456-oa6hh7ky	355	4	phospholipids	phospholipid	NNS
cord-276456-oa6hh7ky	355	5	and	and	CC
cord-276456-oa6hh7ky	355	6	inhibition	inhibition	NN
cord-276456-oa6hh7ky	355	7	of	of	IN
cord-276456-oa6hh7ky	355	8	secretion	secretion	NN
cord-276456-oa6hh7ky	355	9	in	in	IN
cord-276456-oa6hh7ky	355	10	permeabilized	permeabilized	JJ
cord-276456-oa6hh7ky	355	11	cells	cell	NNS
cord-276456-oa6hh7ky	355	12	caused	cause	VBN
cord-276456-oa6hh7ky	355	13	by	by	IN
cord-276456-oa6hh7ky	355	14	a	a	DT
cord-276456-oa6hh7ky	355	15	bacterial	bacterial	JJ
cord-276456-oa6hh7ky	355	16	phospholipase	phospholipase	NN
cord-276456-oa6hh7ky	355	17	C	c	NN
cord-276456-oa6hh7ky	355	18	and	and	CC
cord-276456-oa6hh7ky	355	19	removal	removal	NN
cord-276456-oa6hh7ky	355	20	of	of	IN
cord-276456-oa6hh7ky	355	21	ATP	ATP	NNP
cord-276456-oa6hh7ky	355	22	Catecholamine	Catecholamine	NNP
cord-276456-oa6hh7ky	355	23	secretion	secretion	NN
cord-276456-oa6hh7ky	355	24	from	from	IN
cord-276456-oa6hh7ky	355	25	digitonin	digitonin	NN
cord-276456-oa6hh7ky	355	26	-	-	HYPH
cord-276456-oa6hh7ky	355	27	treated	treat	VBN
cord-276456-oa6hh7ky	355	28	PC12	pc12	JJ
cord-276456-oa6hh7ky	355	29	cells	cell	NNS
cord-276456-oa6hh7ky	355	30	.	.	.
cord-276456-oa6hh7ky	356	1	Effects	effect	NNS
cord-276456-oa6hh7ky	356	2	of	of	IN
cord-276456-oa6hh7ky	356	3	Ca	Ca	NNP
cord-276456-oa6hh7ky	356	4	2þ	2þ	CD
cord-276456-oa6hh7ky	356	5	,	,	,
cord-276456-oa6hh7ky	356	6	ATP	ATP	NNP
cord-276456-oa6hh7ky	356	7	,	,	,
cord-276456-oa6hh7ky	356	8	and	and	CC
cord-276456-oa6hh7ky	356	9	protein	protein	NN
cord-276456-oa6hh7ky	356	10	kinase	kinase	NN
cord-276456-oa6hh7ky	356	11	C	C	NNP
cord-276456-oa6hh7ky	356	12	activators	activator	NNS
cord-276456-oa6hh7ky	356	13	ARF6	ARF6	NNP
cord-276456-oa6hh7ky	356	14	regulates	regulate	VBZ
cord-276456-oa6hh7ky	356	15	a	a	DT
cord-276456-oa6hh7ky	356	16	plasma	plasma	NN
cord-276456-oa6hh7ky	356	17	membrane	membrane	NN
cord-276456-oa6hh7ky	356	18	pool	pool	NN
cord-276456-oa6hh7ky	356	19	of	of	IN
cord-276456-oa6hh7ky	356	20	phosphatidylinositol(4,5)bisphosphate	phosphatidylinositol(4,5)bisphosphate	NN
cord-276456-oa6hh7ky	356	21	required	require	VBN
cord-276456-oa6hh7ky	356	22	for	for	IN
cord-276456-oa6hh7ky	356	23	regulated	regulate	VBN
cord-276456-oa6hh7ky	356	24	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	357	1	A	a	DT
cord-276456-oa6hh7ky	357	2	pleckstrin	pleckstrin	NN
cord-276456-oa6hh7ky	357	3	homology	homology	NN
cord-276456-oa6hh7ky	357	4	domain	domain	NN
cord-276456-oa6hh7ky	357	5	specific	specific	JJ
cord-276456-oa6hh7ky	357	6	for	for	IN
cord-276456-oa6hh7ky	357	7	PtdIns-4	PtdIns-4	NNP
cord-276456-oa6hh7ky	357	8	-	-	SYM
cord-276456-oa6hh7ky	357	9	5-P	5-p	CD
cord-276456-oa6hh7ky	357	10	2	2	CD
cord-276456-oa6hh7ky	357	11	and	and	CC
cord-276456-oa6hh7ky	357	12	fused	fuse	VBN
cord-276456-oa6hh7ky	357	13	to	to	IN
cord-276456-oa6hh7ky	357	14	green	green	JJ
cord-276456-oa6hh7ky	357	15	fluorescent	fluorescent	NN
cord-276456-oa6hh7ky	357	16	protein	protein	NN
cord-276456-oa6hh7ky	357	17	identifies	identify	VBZ
cord-276456-oa6hh7ky	357	18	plasma	plasma	NN
cord-276456-oa6hh7ky	357	19	membrane	membrane	NN
cord-276456-oa6hh7ky	357	20	PtdIns-4	PtdIns-4	NNP
cord-276456-oa6hh7ky	357	21	-	-	HYPH
cord-276456-oa6hh7ky	357	22	5-P	5-p	CD
cord-276456-oa6hh7ky	357	23	2	2	CD
cord-276456-oa6hh7ky	357	24	as	as	IN
cord-276456-oa6hh7ky	357	25	being	be	VBG
cord-276456-oa6hh7ky	357	26	important	important	JJ
cord-276456-oa6hh7ky	357	27	in	in	IN
cord-276456-oa6hh7ky	357	28	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	357	29	Nonclassical	Nonclassical	NNP
cord-276456-oa6hh7ky	357	30	PITPs	PITPs	NNPS
cord-276456-oa6hh7ky	357	31	activate	activate	VBP
cord-276456-oa6hh7ky	357	32	PLD	PLD	NNP
cord-276456-oa6hh7ky	357	33	via	via	IN
cord-276456-oa6hh7ky	357	34	the	the	DT
cord-276456-oa6hh7ky	357	35	Stt4p	stt4p	NN
cord-276456-oa6hh7ky	357	36	PtdIns-4-kinase	ptdins-4-kinase	NN
cord-276456-oa6hh7ky	357	37	and	and	CC
cord-276456-oa6hh7ky	357	38	modulate	modulate	VB
cord-276456-oa6hh7ky	357	39	function	function	NN
cord-276456-oa6hh7ky	357	40	of	of	IN
cord-276456-oa6hh7ky	357	41	late	late	JJ
cord-276456-oa6hh7ky	357	42	stages	stage	NNS
cord-276456-oa6hh7ky	357	43	of	of	IN
cord-276456-oa6hh7ky	357	44	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	357	45	in	in	IN
cord-276456-oa6hh7ky	357	46	vegetative	vegetative	JJ
cord-276456-oa6hh7ky	357	47	yeast	yeast	NN
cord-276456-oa6hh7ky	357	48	Exo70	Exo70	NNP
cord-276456-oa6hh7ky	357	49	interacts	interact	VBZ
cord-276456-oa6hh7ky	357	50	with	with	IN
cord-276456-oa6hh7ky	357	51	phospholipids	phospholipid	NNS
cord-276456-oa6hh7ky	357	52	and	and	CC
cord-276456-oa6hh7ky	357	53	mediates	mediate	VBZ
cord-276456-oa6hh7ky	357	54	the	the	DT
cord-276456-oa6hh7ky	357	55	targeting	targeting	NN
cord-276456-oa6hh7ky	357	56	of	of	IN
cord-276456-oa6hh7ky	357	57	the	the	DT
cord-276456-oa6hh7ky	357	58	exocyst	exocyst	NN
cord-276456-oa6hh7ky	357	59	to	to	IN
cord-276456-oa6hh7ky	357	60	the	the	DT
cord-276456-oa6hh7ky	357	61	plasma	plasma	NN
cord-276456-oa6hh7ky	357	62	membrane	membrane	NN
cord-276456-oa6hh7ky	357	63	Phosphoinositides	Phosphoinositides	NNP
cord-276456-oa6hh7ky	357	64	in	in	IN
cord-276456-oa6hh7ky	357	65	cell	cell	NN
cord-276456-oa6hh7ky	357	66	regulation	regulation	NN
cord-276456-oa6hh7ky	357	67	and	and	CC
cord-276456-oa6hh7ky	357	68	membrane	membrane	NN
cord-276456-oa6hh7ky	357	69	dynamics	dynamic	NNS
cord-276456-oa6hh7ky	357	70	Clustering	Clustering	NNP
cord-276456-oa6hh7ky	357	71	of	of	IN
cord-276456-oa6hh7ky	357	72	syntaxin-1A	syntaxin-1A	NNP
cord-276456-oa6hh7ky	357	73	in	in	IN
cord-276456-oa6hh7ky	357	74	model	model	NN
cord-276456-oa6hh7ky	357	75	membranes	membrane	NNS
cord-276456-oa6hh7ky	357	76	is	be	VBZ
cord-276456-oa6hh7ky	357	77	modulated	modulate	VBN
cord-276456-oa6hh7ky	357	78	by	by	IN
cord-276456-oa6hh7ky	357	79	phosphatidylinositol	phosphatidylinositol	JJ
cord-276456-oa6hh7ky	357	80	4,5-bisphosphate	4,5-bisphosphate	CD
cord-276456-oa6hh7ky	357	81	and	and	CC
cord-276456-oa6hh7ky	357	82	cholesterol	cholesterol	VB
cord-276456-oa6hh7ky	357	83	A	a	DT
cord-276456-oa6hh7ky	357	84	specific	specific	JJ
cord-276456-oa6hh7ky	357	85	point	point	NN
cord-276456-oa6hh7ky	357	86	mutant	mutant	JJ
cord-276456-oa6hh7ky	357	87	at	at	IN
cord-276456-oa6hh7ky	357	88	position	position	NN
cord-276456-oa6hh7ky	357	89	1	1	CD
cord-276456-oa6hh7ky	357	90	of	of	IN
cord-276456-oa6hh7ky	357	91	the	the	DT
cord-276456-oa6hh7ky	357	92	influenza	influenza	NN
cord-276456-oa6hh7ky	357	93	hemagglutinin	hemagglutinin	NNP
cord-276456-oa6hh7ky	357	94	fusion	fusion	NNP
cord-276456-oa6hh7ky	357	95	peptide	peptide	NN
cord-276456-oa6hh7ky	357	96	displays	display	VBZ
cord-276456-oa6hh7ky	357	97	a	a	DT
cord-276456-oa6hh7ky	357	98	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	357	99	phenotype	phenotype	NN
cord-276456-oa6hh7ky	357	100	Structure	structure	NN
cord-276456-oa6hh7ky	357	101	of	of	IN
cord-276456-oa6hh7ky	357	102	the	the	DT
cord-276456-oa6hh7ky	357	103	haemagglutinin	haemagglutinin	NNP
cord-276456-oa6hh7ky	357	104	membrane	membrane	NN
cord-276456-oa6hh7ky	357	105	glycoprotein	glycoprotein	NN
cord-276456-oa6hh7ky	357	106	of	of	IN
cord-276456-oa6hh7ky	357	107	influenza	influenza	NN
cord-276456-oa6hh7ky	357	108	virus	virus	NN
cord-276456-oa6hh7ky	357	109	at	at	IN
cord-276456-oa6hh7ky	357	110	3	3	CD
cord-276456-oa6hh7ky	357	111	A	a	DT
cord-276456-oa6hh7ky	357	112	resolution	resolution	NN
cord-276456-oa6hh7ky	357	113	Structure	structure	NN
cord-276456-oa6hh7ky	357	114	of	of	IN
cord-276456-oa6hh7ky	357	115	influenza	influenza	NN
cord-276456-oa6hh7ky	357	116	haemagglutinin	haemagglutinin	NNP
cord-276456-oa6hh7ky	357	117	at	at	IN
cord-276456-oa6hh7ky	357	118	the	the	DT
cord-276456-oa6hh7ky	357	119	pH	pH	NNP
cord-276456-oa6hh7ky	357	120	of	of	IN
cord-276456-oa6hh7ky	357	121	membrane	membrane	NN
cord-276456-oa6hh7ky	357	122	fusion	fusion	NN
cord-276456-oa6hh7ky	357	123	Helenius	Helenius	NNP
cord-276456-oa6hh7ky	357	124	,	,	,
cord-276456-oa6hh7ky	357	125	A.	A.	NNP
cord-276456-oa6hh7ky	357	126	Folding	folding	NN
cord-276456-oa6hh7ky	357	127	,	,	,
cord-276456-oa6hh7ky	357	128	trimerization	trimerization	NN
cord-276456-oa6hh7ky	357	129	,	,	,
cord-276456-oa6hh7ky	357	130	and	and	CC
cord-276456-oa6hh7ky	357	131	transport	transport	NN
cord-276456-oa6hh7ky	357	132	are	be	VBP
cord-276456-oa6hh7ky	357	133	sequential	sequential	JJ
cord-276456-oa6hh7ky	357	134	events	event	NNS
cord-276456-oa6hh7ky	357	135	in	in	IN
cord-276456-oa6hh7ky	357	136	the	the	DT
cord-276456-oa6hh7ky	357	137	biogenesis	biogenesis	NN
cord-276456-oa6hh7ky	357	138	of	of	IN
cord-276456-oa6hh7ky	357	139	influenza	influenza	NN
cord-276456-oa6hh7ky	357	140	virus	virus	NN
cord-276456-oa6hh7ky	357	141	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	357	142	Receptor	Receptor	NNP
cord-276456-oa6hh7ky	357	143	binding	binding	NN
cord-276456-oa6hh7ky	357	144	and	and	CC
cord-276456-oa6hh7ky	357	145	membrane	membrane	NN
cord-276456-oa6hh7ky	357	146	fusion	fusion	NN
cord-276456-oa6hh7ky	357	147	in	in	IN
cord-276456-oa6hh7ky	357	148	virus	virus	NN
cord-276456-oa6hh7ky	357	149	entry	entry	NN
cord-276456-oa6hh7ky	357	150	:	:	:
cord-276456-oa6hh7ky	357	151	the	the	DT
cord-276456-oa6hh7ky	357	152	influenza	influenza	NN
cord-276456-oa6hh7ky	357	153	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	357	154	Membrane	Membrane	NNP
cord-276456-oa6hh7ky	357	155	structure	structure	NN
cord-276456-oa6hh7ky	357	156	and	and	CC
cord-276456-oa6hh7ky	357	157	fusion	fusion	NN
cord-276456-oa6hh7ky	357	158	-	-	HYPH
cord-276456-oa6hh7ky	357	159	triggering	trigger	VBG
cord-276456-oa6hh7ky	357	160	conformational	conformational	JJ
cord-276456-oa6hh7ky	357	161	change	change	NN
cord-276456-oa6hh7ky	357	162	of	of	IN
cord-276456-oa6hh7ky	357	163	the	the	DT
cord-276456-oa6hh7ky	357	164	fusion	fusion	NN
cord-276456-oa6hh7ky	357	165	domain	domain	NN
cord-276456-oa6hh7ky	357	166	from	from	IN
cord-276456-oa6hh7ky	357	167	influenza	influenza	NN
cord-276456-oa6hh7ky	357	168	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	357	169	Protonation	protonation	NN
cord-276456-oa6hh7ky	357	170	and	and	CC
cord-276456-oa6hh7ky	357	171	stability	stability	NN
cord-276456-oa6hh7ky	357	172	of	of	IN
cord-276456-oa6hh7ky	357	173	the	the	DT
cord-276456-oa6hh7ky	357	174	globular	globular	JJ
cord-276456-oa6hh7ky	357	175	domain	domain	NN
cord-276456-oa6hh7ky	357	176	of	of	IN
cord-276456-oa6hh7ky	357	177	influenza	influenza	NN
cord-276456-oa6hh7ky	357	178	virus	virus	NN
cord-276456-oa6hh7ky	357	179	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	357	180	Early	early	JJ
cord-276456-oa6hh7ky	357	181	steps	step	NNS
cord-276456-oa6hh7ky	357	182	of	of	IN
cord-276456-oa6hh7ky	357	183	the	the	DT
cord-276456-oa6hh7ky	357	184	conformational	conformational	JJ
cord-276456-oa6hh7ky	357	185	change	change	NN
cord-276456-oa6hh7ky	357	186	of	of	IN
cord-276456-oa6hh7ky	357	187	influenza	influenza	NN
cord-276456-oa6hh7ky	357	188	virus	virus	NN
cord-276456-oa6hh7ky	357	189	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	357	190	to	to	IN
cord-276456-oa6hh7ky	357	191	a	a	DT
cord-276456-oa6hh7ky	357	192	fusion	fusion	NN
cord-276456-oa6hh7ky	357	193	active	active	JJ
cord-276456-oa6hh7ky	357	194	state	state	NN
cord-276456-oa6hh7ky	357	195	:	:	:
cord-276456-oa6hh7ky	357	196	stability	stability	NN
cord-276456-oa6hh7ky	357	197	and	and	CC
cord-276456-oa6hh7ky	357	198	energetics	energetic	NNS
cord-276456-oa6hh7ky	357	199	of	of	IN
cord-276456-oa6hh7ky	357	200	the	the	DT
cord-276456-oa6hh7ky	357	201	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	358	1	The	the	DT
cord-276456-oa6hh7ky	358	2	relevance	relevance	NN
cord-276456-oa6hh7ky	358	3	of	of	IN
cord-276456-oa6hh7ky	358	4	salt	salt	NN
cord-276456-oa6hh7ky	358	5	bridges	bridge	NNS
cord-276456-oa6hh7ky	358	6	for	for	IN
cord-276456-oa6hh7ky	358	7	the	the	DT
cord-276456-oa6hh7ky	358	8	stability	stability	NN
cord-276456-oa6hh7ky	358	9	of	of	IN
cord-276456-oa6hh7ky	358	10	the	the	DT
cord-276456-oa6hh7ky	358	11	influenza	influenza	NN
cord-276456-oa6hh7ky	358	12	virus	virus	NN
cord-276456-oa6hh7ky	358	13	hemagglutinin	hemagglutinin	VBD
cord-276456-oa6hh7ky	358	14	A	a	DT
cord-276456-oa6hh7ky	358	15	soluble	soluble	JJ
cord-276456-oa6hh7ky	358	16	domain	domain	NN
cord-276456-oa6hh7ky	358	17	of	of	IN
cord-276456-oa6hh7ky	358	18	the	the	DT
cord-276456-oa6hh7ky	358	19	membrane	membrane	NN
cord-276456-oa6hh7ky	358	20	-	-	HYPH
cord-276456-oa6hh7ky	358	21	anchoring	anchor	VBG
cord-276456-oa6hh7ky	358	22	chain	chain	NN
cord-276456-oa6hh7ky	358	23	of	of	IN
cord-276456-oa6hh7ky	358	24	influenza	influenza	NN
cord-276456-oa6hh7ky	358	25	virus	virus	NN
cord-276456-oa6hh7ky	358	26	hemagglutinin	hemagglutinin	NNP
cord-276456-oa6hh7ky	358	27	(	(	-LRB-
cord-276456-oa6hh7ky	358	28	HA2	HA2	NNP
cord-276456-oa6hh7ky	358	29	)	)	-RRB-
cord-276456-oa6hh7ky	358	30	folds	fold	VBZ
cord-276456-oa6hh7ky	358	31	in	in	IN
cord-276456-oa6hh7ky	358	32	Escherichia	Escherichia	NNP
cord-276456-oa6hh7ky	358	33	coli	coli	NNS
cord-276456-oa6hh7ky	358	34	into	into	IN
cord-276456-oa6hh7ky	358	35	the	the	DT
cord-276456-oa6hh7ky	358	36	low	low	JJ
cord-276456-oa6hh7ky	358	37	-	-	HYPH
cord-276456-oa6hh7ky	358	38	pH	ph	NN
cord-276456-oa6hh7ky	358	39	-	-	HYPH
cord-276456-oa6hh7ky	358	40	induced	induce	VBN
cord-276456-oa6hh7ky	358	41	conformation	conformation	NN
cord-276456-oa6hh7ky	358	42	cDNA	cdna	NN
cord-276456-oa6hh7ky	358	43	cloning	cloning	NN
cord-276456-oa6hh7ky	358	44	of	of	IN
cord-276456-oa6hh7ky	358	45	component	component	NN
cord-276456-oa6hh7ky	358	46	A	a	NN
cord-276456-oa6hh7ky	358	47	of	of	IN
cord-276456-oa6hh7ky	358	48	Rab	Rab	NNP
cord-276456-oa6hh7ky	358	49	geranylgeranyl	geranylgeranyl	NNP
cord-276456-oa6hh7ky	358	50	transferase	transferase	NN
cord-276456-oa6hh7ky	358	51	and	and	CC
cord-276456-oa6hh7ky	358	52	demonstration	demonstration	NN
cord-276456-oa6hh7ky	358	53	of	of	IN
cord-276456-oa6hh7ky	358	54	its	-PRON-	PRP$
cord-276456-oa6hh7ky	358	55	role	role	NN
cord-276456-oa6hh7ky	358	56	as	as	IN
cord-276456-oa6hh7ky	358	57	a	a	DT
cord-276456-oa6hh7ky	358	58	Rab	Rab	NNP
cord-276456-oa6hh7ky	358	59	escort	escort	NN
cord-276456-oa6hh7ky	358	60	protein	protein	NN
cord-276456-oa6hh7ky	358	61	Specific	specific	JJ
cord-276456-oa6hh7ky	358	62	single	single	JJ
cord-276456-oa6hh7ky	358	63	or	or	CC
cord-276456-oa6hh7ky	358	64	double	double	JJ
cord-276456-oa6hh7ky	358	65	proline	proline	NN
cord-276456-oa6hh7ky	358	66	substitutions	substitution	NNS
cord-276456-oa6hh7ky	358	67	in	in	IN
cord-276456-oa6hh7ky	358	68	the	the	DT
cord-276456-oa6hh7ky	358	69	'	'	''
cord-276456-oa6hh7ky	358	70	'	'	``
cord-276456-oa6hh7ky	358	71	spring	spring	NN
cord-276456-oa6hh7ky	358	72	-	-	HYPH
cord-276456-oa6hh7ky	358	73	loaded	load	VBN
cord-276456-oa6hh7ky	358	74	'	'	''
cord-276456-oa6hh7ky	358	75	'	'	``
cord-276456-oa6hh7ky	358	76	coiled	coil	VBN
cord-276456-oa6hh7ky	358	77	-	-	HYPH
cord-276456-oa6hh7ky	358	78	coil	coil	NN
cord-276456-oa6hh7ky	358	79	region	region	NN
cord-276456-oa6hh7ky	358	80	of	of	IN
cord-276456-oa6hh7ky	358	81	the	the	DT
cord-276456-oa6hh7ky	358	82	influenza	influenza	NN
cord-276456-oa6hh7ky	358	83	hemagglutinin	hemagglutinin	NNS
cord-276456-oa6hh7ky	358	84	impair	impair	VB
cord-276456-oa6hh7ky	358	85	or	or	CC
cord-276456-oa6hh7ky	358	86	abolish	abolish	VB
cord-276456-oa6hh7ky	358	87	membrane	membrane	NN
cord-276456-oa6hh7ky	358	88	fusion	fusion	NN
cord-276456-oa6hh7ky	358	89	activity	activity	NN
cord-276456-oa6hh7ky	358	90	New	new	JJ
cord-276456-oa6hh7ky	358	91	insight	insight	NN
cord-276456-oa6hh7ky	358	92	into	into	IN
cord-276456-oa6hh7ky	358	93	the	the	DT
cord-276456-oa6hh7ky	358	94	spring	spring	NN
cord-276456-oa6hh7ky	358	95	-	-	HYPH
cord-276456-oa6hh7ky	358	96	loaded	load	VBN
cord-276456-oa6hh7ky	358	97	conformational	conformational	JJ
cord-276456-oa6hh7ky	358	98	change	change	NN
cord-276456-oa6hh7ky	358	99	of	of	IN
cord-276456-oa6hh7ky	358	100	influenza	influenza	NN
cord-276456-oa6hh7ky	358	101	virus	virus	NN
cord-276456-oa6hh7ky	358	102	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	358	103	Leash	Leash	NNP
cord-276456-oa6hh7ky	358	104	in	in	IN
cord-276456-oa6hh7ky	358	105	the	the	DT
cord-276456-oa6hh7ky	358	106	groove	groove	NN
cord-276456-oa6hh7ky	358	107	mechanism	mechanism	NN
cord-276456-oa6hh7ky	358	108	of	of	IN
cord-276456-oa6hh7ky	358	109	membrane	membrane	NN
cord-276456-oa6hh7ky	358	110	fusion	fusion	NN
cord-276456-oa6hh7ky	359	1	A	a	DT
cord-276456-oa6hh7ky	359	2	host	host	NN
cord-276456-oa6hh7ky	359	3	-	-	HYPH
cord-276456-oa6hh7ky	359	4	guest	guest	NN
cord-276456-oa6hh7ky	359	5	system	system	NN
cord-276456-oa6hh7ky	359	6	to	to	TO
cord-276456-oa6hh7ky	359	7	study	study	VB
cord-276456-oa6hh7ky	359	8	structure	structure	NN
cord-276456-oa6hh7ky	359	9	-	-	HYPH
cord-276456-oa6hh7ky	359	10	function	function	NN
cord-276456-oa6hh7ky	359	11	relationships	relationship	NNS
cord-276456-oa6hh7ky	359	12	of	of	IN
cord-276456-oa6hh7ky	359	13	membrane	membrane	NN
cord-276456-oa6hh7ky	359	14	fusion	fusion	NN
cord-276456-oa6hh7ky	359	15	peptides	peptide	NNS
cord-276456-oa6hh7ky	359	16	Structural	structural	JJ
cord-276456-oa6hh7ky	359	17	intermediates	intermediate	NNS
cord-276456-oa6hh7ky	359	18	in	in	IN
cord-276456-oa6hh7ky	359	19	influenza	influenza	NN
cord-276456-oa6hh7ky	359	20	haemagglutinin	haemagglutinin	NNP
cord-276456-oa6hh7ky	359	21	-	-	HYPH
cord-276456-oa6hh7ky	359	22	mediated	mediate	VBN
cord-276456-oa6hh7ky	359	23	fusion	fusion	NN
cord-276456-oa6hh7ky	359	24	Composition	composition	NN
cord-276456-oa6hh7ky	359	25	and	and	CC
cord-276456-oa6hh7ky	359	26	functions	function	NNS
cord-276456-oa6hh7ky	359	27	of	of	IN
cord-276456-oa6hh7ky	359	28	the	the	DT
cord-276456-oa6hh7ky	359	29	influenza	influenza	NN
cord-276456-oa6hh7ky	359	30	fusion	fusion	NN
cord-276456-oa6hh7ky	359	31	peptide	peptide	NN
cord-276456-oa6hh7ky	359	32	Membrane	Membrane	NNP
cord-276456-oa6hh7ky	359	33	fusion	fusion	NN
cord-276456-oa6hh7ky	359	34	by	by	IN
cord-276456-oa6hh7ky	359	35	influenza	influenza	NN
cord-276456-oa6hh7ky	359	36	hemagglutinin	hemagglutinin	NNP
cord-276456-oa6hh7ky	359	37	Studies	study	NNS
cord-276456-oa6hh7ky	359	38	on	on	IN
cord-276456-oa6hh7ky	359	39	the	the	DT
cord-276456-oa6hh7ky	359	40	mechanism	mechanism	NN
cord-276456-oa6hh7ky	359	41	of	of	IN
cord-276456-oa6hh7ky	359	42	membrane	membrane	NN
cord-276456-oa6hh7ky	359	43	fusion	fusion	NN
cord-276456-oa6hh7ky	359	44	:	:	:
cord-276456-oa6hh7ky	359	45	site	site	NN
cord-276456-oa6hh7ky	359	46	-	-	HYPH
cord-276456-oa6hh7ky	359	47	specific	specific	JJ
cord-276456-oa6hh7ky	359	48	mutagenesis	mutagenesis	NN
cord-276456-oa6hh7ky	359	49	of	of	IN
cord-276456-oa6hh7ky	359	50	the	the	DT
cord-276456-oa6hh7ky	359	51	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	359	52	of	of	IN
cord-276456-oa6hh7ky	359	53	influenza	influenza	NN
cord-276456-oa6hh7ky	359	54	virus	virus	NN
cord-276456-oa6hh7ky	359	55	Hypothesis	hypothesis	NN
cord-276456-oa6hh7ky	359	56	:	:	:
cord-276456-oa6hh7ky	359	57	spring	spring	NN
cord-276456-oa6hh7ky	359	58	-	-	HYPH
cord-276456-oa6hh7ky	359	59	loaded	load	VBN
cord-276456-oa6hh7ky	359	60	boomerang	boomerang	NN
cord-276456-oa6hh7ky	359	61	mechanism	mechanism	NN
cord-276456-oa6hh7ky	359	62	of	of	IN
cord-276456-oa6hh7ky	359	63	influenza	influenza	NN
cord-276456-oa6hh7ky	359	64	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	359	65	-	-	HYPH
cord-276456-oa6hh7ky	359	66	mediated	mediate	VBN
cord-276456-oa6hh7ky	359	67	membrane	membrane	NN
cord-276456-oa6hh7ky	359	68	fusion	fusion	NN
cord-276456-oa6hh7ky	360	1	Early	early	JJ
cord-276456-oa6hh7ky	360	2	endosomal	endosomal	JJ
cord-276456-oa6hh7ky	360	3	SNAREs	snare	NNS
cord-276456-oa6hh7ky	360	4	form	form	VBP
cord-276456-oa6hh7ky	360	5	a	a	DT
cord-276456-oa6hh7ky	360	6	structurally	structurally	RB
cord-276456-oa6hh7ky	360	7	conserved	conserved	JJ
cord-276456-oa6hh7ky	360	8	SNARE	snare	NN
cord-276456-oa6hh7ky	360	9	complex	complex	NN
cord-276456-oa6hh7ky	360	10	and	and	CC
cord-276456-oa6hh7ky	360	11	fuse	fuse	NN
cord-276456-oa6hh7ky	360	12	liposomes	liposome	NNS
cord-276456-oa6hh7ky	360	13	with	with	IN
cord-276456-oa6hh7ky	360	14	multiple	multiple	JJ
cord-276456-oa6hh7ky	360	15	topologies	topology	NNS
cord-276456-oa6hh7ky	361	1	The	the	DT
cord-276456-oa6hh7ky	361	2	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	361	3	tail	tail	NN
cord-276456-oa6hh7ky	361	4	slows	slow	VBZ
cord-276456-oa6hh7ky	361	5	the	the	DT
cord-276456-oa6hh7ky	361	6	folding	folding	NN
cord-276456-oa6hh7ky	361	7	of	of	IN
cord-276456-oa6hh7ky	361	8	human	human	JJ
cord-276456-oa6hh7ky	361	9	immunodeficiency	immunodeficiency	NN
cord-276456-oa6hh7ky	361	10	virus	virus	NN
cord-276456-oa6hh7ky	361	11	type	type	NN
cord-276456-oa6hh7ky	361	12	1	1	CD
cord-276456-oa6hh7ky	361	13	Env	Env	NNP
cord-276456-oa6hh7ky	361	14	from	from	IN
cord-276456-oa6hh7ky	361	15	a	a	DT
cord-276456-oa6hh7ky	361	16	late	late	JJ
cord-276456-oa6hh7ky	361	17	prebundle	prebundle	NN
cord-276456-oa6hh7ky	361	18	configuration	configuration	NN
cord-276456-oa6hh7ky	361	19	into	into	IN
cord-276456-oa6hh7ky	361	20	the	the	DT
cord-276456-oa6hh7ky	361	21	six	six	CD
cord-276456-oa6hh7ky	361	22	-	-	HYPH
cord-276456-oa6hh7ky	361	23	helix	helix	NN
cord-276456-oa6hh7ky	361	24	bundle	bundle	NN
cord-276456-oa6hh7ky	361	25	Fusion	Fusion	NNP
cord-276456-oa6hh7ky	361	26	peptide	peptide	NN
cord-276456-oa6hh7ky	361	27	of	of	IN
cord-276456-oa6hh7ky	361	28	influenza	influenza	NN
cord-276456-oa6hh7ky	361	29	hemagglutinin	hemagglutinin	NNP
cord-276456-oa6hh7ky	361	30	requires	require	VBZ
cord-276456-oa6hh7ky	361	31	a	a	DT
cord-276456-oa6hh7ky	361	32	fixed	fix	VBN
cord-276456-oa6hh7ky	361	33	angle	angle	NN
cord-276456-oa6hh7ky	361	34	boomerang	boomerang	NN
cord-276456-oa6hh7ky	361	35	structure	structure	NN
cord-276456-oa6hh7ky	361	36	for	for	IN
cord-276456-oa6hh7ky	361	37	activity	activity	NN
cord-276456-oa6hh7ky	361	38	Locking	lock	VBG
cord-276456-oa6hh7ky	361	39	the	the	DT
cord-276456-oa6hh7ky	361	40	kink	kink	NN
cord-276456-oa6hh7ky	361	41	in	in	IN
cord-276456-oa6hh7ky	361	42	the	the	DT
cord-276456-oa6hh7ky	361	43	influenza	influenza	NN
cord-276456-oa6hh7ky	361	44	hemagglutinin	hemagglutinin	NNP
cord-276456-oa6hh7ky	361	45	fusion	fusion	NN
cord-276456-oa6hh7ky	361	46	domain	domain	NN
cord-276456-oa6hh7ky	361	47	structure	structure	NN
cord-276456-oa6hh7ky	361	48	Membrane	Membrane	NNP
cord-276456-oa6hh7ky	361	49	fusion	fusion	NN
cord-276456-oa6hh7ky	361	50	mediated	mediate	VBN
cord-276456-oa6hh7ky	361	51	by	by	IN
cord-276456-oa6hh7ky	361	52	the	the	DT
cord-276456-oa6hh7ky	361	53	influenza	influenza	NN
cord-276456-oa6hh7ky	361	54	virus	virus	NN
cord-276456-oa6hh7ky	361	55	hemagglutinin	hemagglutinin	NNP
cord-276456-oa6hh7ky	361	56	requires	require	VBZ
cord-276456-oa6hh7ky	361	57	the	the	DT
cord-276456-oa6hh7ky	361	58	concerted	concerted	JJ
cord-276456-oa6hh7ky	361	59	action	action	NN
cord-276456-oa6hh7ky	361	60	of	of	IN
cord-276456-oa6hh7ky	361	61	at	at	RB
cord-276456-oa6hh7ky	361	62	least	least	RBS
cord-276456-oa6hh7ky	361	63	three	three	CD
cord-276456-oa6hh7ky	361	64	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	361	65	trimers	trimer	NNS
cord-276456-oa6hh7ky	362	1	Multiple	multiple	JJ
cord-276456-oa6hh7ky	362	2	local	local	JJ
cord-276456-oa6hh7ky	362	3	contact	contact	NN
cord-276456-oa6hh7ky	362	4	sites	site	NNS
cord-276456-oa6hh7ky	362	5	are	be	VBP
cord-276456-oa6hh7ky	362	6	induced	induce	VBN
cord-276456-oa6hh7ky	362	7	by	by	IN
cord-276456-oa6hh7ky	362	8	GPI	GPI	NNP
cord-276456-oa6hh7ky	362	9	-	-	HYPH
cord-276456-oa6hh7ky	362	10	linked	link	VBN
cord-276456-oa6hh7ky	362	11	influenza	influenza	NN
cord-276456-oa6hh7ky	362	12	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	362	13	during	during	IN
cord-276456-oa6hh7ky	362	14	hemifusion	hemifusion	NN
cord-276456-oa6hh7ky	362	15	and	and	CC
cord-276456-oa6hh7ky	362	16	flickering	flickering	JJ
cord-276456-oa6hh7ky	362	17	pore	pore	NN
cord-276456-oa6hh7ky	362	18	formation	formation	NN
cord-276456-oa6hh7ky	362	19	Secondary	secondary	JJ
cord-276456-oa6hh7ky	362	20	structure	structure	NN
cord-276456-oa6hh7ky	362	21	,	,	,
cord-276456-oa6hh7ky	362	22	orientation	orientation	NN
cord-276456-oa6hh7ky	362	23	,	,	,
cord-276456-oa6hh7ky	362	24	oligomerization	oligomerization	NN
cord-276456-oa6hh7ky	362	25	,	,	,
cord-276456-oa6hh7ky	362	26	and	and	CC
cord-276456-oa6hh7ky	362	27	lipid	lipid	NN
cord-276456-oa6hh7ky	362	28	interactions	interaction	NNS
cord-276456-oa6hh7ky	362	29	of	of	IN
cord-276456-oa6hh7ky	362	30	the	the	DT
cord-276456-oa6hh7ky	362	31	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	362	32	domain	domain	NN
cord-276456-oa6hh7ky	362	33	of	of	IN
cord-276456-oa6hh7ky	362	34	influenza	influenza	NN
cord-276456-oa6hh7ky	362	35	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	362	36	Endosome	Endosome	NNP
cord-276456-oa6hh7ky	362	37	-	-	HYPH
cord-276456-oa6hh7ky	362	38	to	to	IN
cord-276456-oa6hh7ky	362	39	-	-	HYPH
cord-276456-oa6hh7ky	362	40	cytosol	cytosol	NN
cord-276456-oa6hh7ky	362	41	transport	transport	NN
cord-276456-oa6hh7ky	362	42	of	of	IN
cord-276456-oa6hh7ky	362	43	viral	viral	JJ
cord-276456-oa6hh7ky	362	44	nucleocapsids	nucleocapsid	NNS
cord-276456-oa6hh7ky	362	45	Conformational	Conformational	NNP
cord-276456-oa6hh7ky	362	46	changes	change	NNS
cord-276456-oa6hh7ky	362	47	and	and	CC
cord-276456-oa6hh7ky	362	48	fusion	fusion	NN
cord-276456-oa6hh7ky	362	49	activity	activity	NN
cord-276456-oa6hh7ky	362	50	of	of	IN
cord-276456-oa6hh7ky	362	51	influenza	influenza	NN
cord-276456-oa6hh7ky	362	52	virus	virus	NN
cord-276456-oa6hh7ky	362	53	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	362	54	of	of	IN
cord-276456-oa6hh7ky	362	55	the	the	DT
cord-276456-oa6hh7ky	362	56	H2	H2	NNP
cord-276456-oa6hh7ky	362	57	and	and	CC
cord-276456-oa6hh7ky	362	58	H3	H3	NNP
cord-276456-oa6hh7ky	362	59	subtypes	subtype	NNS
cord-276456-oa6hh7ky	362	60	:	:	:
cord-276456-oa6hh7ky	362	61	effects	effect	NNS
cord-276456-oa6hh7ky	362	62	of	of	IN
cord-276456-oa6hh7ky	362	63	acid	acid	NN
cord-276456-oa6hh7ky	362	64	pretreatment	pretreatment	NN
cord-276456-oa6hh7ky	362	65	Reversible	reversible	JJ
cord-276456-oa6hh7ky	362	66	pH	ph	NN
cord-276456-oa6hh7ky	362	67	-	-	HYPH
cord-276456-oa6hh7ky	362	68	dependent	dependent	JJ
cord-276456-oa6hh7ky	362	69	conformational	conformational	JJ
cord-276456-oa6hh7ky	362	70	change	change	NN
cord-276456-oa6hh7ky	362	71	of	of	IN
cord-276456-oa6hh7ky	362	72	reconstituted	reconstitute	VBN
cord-276456-oa6hh7ky	362	73	influenza	influenza	NN
cord-276456-oa6hh7ky	362	74	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	362	75	Amino	amino	NN
cord-276456-oa6hh7ky	362	76	acid	acid	NN
cord-276456-oa6hh7ky	362	77	sequence	sequence	NN
cord-276456-oa6hh7ky	362	78	requirements	requirement	NNS
cord-276456-oa6hh7ky	362	79	of	of	IN
cord-276456-oa6hh7ky	362	80	the	the	DT
cord-276456-oa6hh7ky	362	81	transmembrane	transmembrane	NN
cord-276456-oa6hh7ky	362	82	and	and	CC
cord-276456-oa6hh7ky	362	83	cytoplasmic	cytoplasmic	JJ
cord-276456-oa6hh7ky	362	84	domains	domain	NNS
cord-276456-oa6hh7ky	362	85	of	of	IN
cord-276456-oa6hh7ky	362	86	influenza	influenza	NN
cord-276456-oa6hh7ky	362	87	virus	virus	NN
cord-276456-oa6hh7ky	362	88	hemagglutinin	hemagglutinin	NN
cord-276456-oa6hh7ky	362	89	for	for	IN
cord-276456-oa6hh7ky	362	90	viable	viable	JJ
cord-276456-oa6hh7ky	362	91	membrane	membrane	NN
cord-276456-oa6hh7ky	362	92	fusion	fusion	NN
cord-276456-oa6hh7ky	362	93	SNAREs	snare	NNS
cord-276456-oa6hh7ky	362	94	-	-	:
cord-276456-oa6hh7ky	362	95	energies	energy	NNS
cord-276456-oa6hh7ky	362	96	for	for	IN
cord-276456-oa6hh7ky	362	97	membrane	membrane	NN
cord-276456-oa6hh7ky	362	98	fusion	fusion	NN
cord-276456-oa6hh7ky	362	99	Crystal	Crystal	NNP
cord-276456-oa6hh7ky	362	100	structure	structure	NN
cord-276456-oa6hh7ky	362	101	of	of	IN
cord-276456-oa6hh7ky	362	102	a	a	DT
cord-276456-oa6hh7ky	362	103	SNARE	snare	NN
cord-276456-oa6hh7ky	362	104	complex	complex	NN
cord-276456-oa6hh7ky	362	105	involved	involve	VBN
cord-276456-oa6hh7ky	362	106	in	in	IN
cord-276456-oa6hh7ky	362	107	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	362	108	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	362	109	at	at	IN
cord-276456-oa6hh7ky	362	110	2.4	2.4	CD
cord-276456-oa6hh7ky	362	111	A	a	DT
cord-276456-oa6hh7ky	362	112	resolution	resolution	NN
cord-276456-oa6hh7ky	362	113	Energetics	energetic	NNS
cord-276456-oa6hh7ky	362	114	and	and	CC
cord-276456-oa6hh7ky	362	115	dynamics	dynamic	NNS
cord-276456-oa6hh7ky	362	116	of	of	IN
cord-276456-oa6hh7ky	362	117	SNAREpin	snarepin	NN
cord-276456-oa6hh7ky	362	118	folding	folding	NN
cord-276456-oa6hh7ky	362	119	across	across	IN
cord-276456-oa6hh7ky	362	120	lipid	lipid	NN
cord-276456-oa6hh7ky	362	121	bilayers	bilayer	NNS
cord-276456-oa6hh7ky	363	1	Single	single	JJ
cord-276456-oa6hh7ky	363	2	molecule	molecule	NN
cord-276456-oa6hh7ky	363	3	probing	probing	NN
cord-276456-oa6hh7ky	363	4	of	of	IN
cord-276456-oa6hh7ky	363	5	SNARE	snare	NN
cord-276456-oa6hh7ky	363	6	proteins	protein	NNS
cord-276456-oa6hh7ky	363	7	by	by	IN
cord-276456-oa6hh7ky	363	8	atomic	atomic	JJ
cord-276456-oa6hh7ky	363	9	force	force	NN
cord-276456-oa6hh7ky	363	10	microscopy	microscopy	NN
cord-276456-oa6hh7ky	363	11	Is	be	VBZ
cord-276456-oa6hh7ky	363	12	assembly	assembly	NN
cord-276456-oa6hh7ky	363	13	of	of	IN
cord-276456-oa6hh7ky	363	14	the	the	DT
cord-276456-oa6hh7ky	363	15	SNARE	snare	NN
cord-276456-oa6hh7ky	363	16	complex	complex	JJ
cord-276456-oa6hh7ky	363	17	enough	enough	RB
cord-276456-oa6hh7ky	363	18	to	to	TO
cord-276456-oa6hh7ky	363	19	fuel	fuel	VB
cord-276456-oa6hh7ky	363	20	membrane	membrane	NN
cord-276456-oa6hh7ky	363	21	fusion	fusion	NN
cord-276456-oa6hh7ky	363	22	Crystal	Crystal	NNP
cord-276456-oa6hh7ky	363	23	structure	structure	NN
cord-276456-oa6hh7ky	363	24	of	of	IN
cord-276456-oa6hh7ky	363	25	the	the	DT
cord-276456-oa6hh7ky	363	26	endosomal	endosomal	NNP
cord-276456-oa6hh7ky	363	27	SNARE	snare	VB
cord-276456-oa6hh7ky	363	28	complex	complex	JJ
cord-276456-oa6hh7ky	364	1	reveals	reveal	VBZ
cord-276456-oa6hh7ky	364	2	common	common	JJ
cord-276456-oa6hh7ky	364	3	structural	structural	JJ
cord-276456-oa6hh7ky	364	4	principles	principle	NNS
cord-276456-oa6hh7ky	364	5	of	of	IN
cord-276456-oa6hh7ky	364	6	all	all	DT
cord-276456-oa6hh7ky	364	7	SNAREs	SNAREs	NNP
cord-276456-oa6hh7ky	364	8	Structure	structure	NN
cord-276456-oa6hh7ky	364	9	and	and	CC
cord-276456-oa6hh7ky	364	10	function	function	NN
cord-276456-oa6hh7ky	364	11	of	of	IN
cord-276456-oa6hh7ky	364	12	SNARE	snare	NN
cord-276456-oa6hh7ky	364	13	and	and	CC
cord-276456-oa6hh7ky	364	14	SNARE	snare	NN
cord-276456-oa6hh7ky	364	15	-	-	HYPH
cord-276456-oa6hh7ky	364	16	interacting	interact	VBG
cord-276456-oa6hh7ky	364	17	proteins	protein	NNS
cord-276456-oa6hh7ky	364	18	Structure	Structure	NNP
cord-276456-oa6hh7ky	364	19	of	of	IN
cord-276456-oa6hh7ky	364	20	proteins	protein	NNS
cord-276456-oa6hh7ky	364	21	involved	involve	VBN
cord-276456-oa6hh7ky	364	22	in	in	IN
cord-276456-oa6hh7ky	364	23	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	364	24	vesicle	vesicle	NN
cord-276456-oa6hh7ky	364	25	fusion	fusion	NN
cord-276456-oa6hh7ky	364	26	in	in	IN
cord-276456-oa6hh7ky	364	27	neurons	neuron	NNS
cord-276456-oa6hh7ky	365	1	Exocytosis	Exocytosis	NNP
cord-276456-oa6hh7ky	365	2	requires	require	VBZ
cord-276456-oa6hh7ky	365	3	asymmetry	asymmetry	NN
cord-276456-oa6hh7ky	365	4	in	in	IN
cord-276456-oa6hh7ky	365	5	the	the	DT
cord-276456-oa6hh7ky	365	6	central	central	JJ
cord-276456-oa6hh7ky	365	7	layer	layer	NN
cord-276456-oa6hh7ky	365	8	of	of	IN
cord-276456-oa6hh7ky	365	9	the	the	DT
cord-276456-oa6hh7ky	365	10	SNARE	snare	NN
cord-276456-oa6hh7ky	365	11	complex	complex	JJ
cord-276456-oa6hh7ky	365	12	SNARE	snare	VBP
cord-276456-oa6hh7ky	365	13	complex	complex	JJ
cord-276456-oa6hh7ky	365	14	zero	zero	CD
cord-276456-oa6hh7ky	365	15	layer	layer	NN
cord-276456-oa6hh7ky	365	16	residues	residue	NNS
cord-276456-oa6hh7ky	365	17	are	be	VBP
cord-276456-oa6hh7ky	365	18	not	not	RB
cord-276456-oa6hh7ky	365	19	critical	critical	JJ
cord-276456-oa6hh7ky	365	20	for	for	IN
cord-276456-oa6hh7ky	365	21	N	n	CD
cord-276456-oa6hh7ky	365	22	-	-	HYPH
cord-276456-oa6hh7ky	365	23	ethylmaleimide	ethylmaleimide	NN
cord-276456-oa6hh7ky	365	24	-	-	HYPH
cord-276456-oa6hh7ky	365	25	sensitive	sensitive	JJ
cord-276456-oa6hh7ky	365	26	factor	factor	NN
cord-276456-oa6hh7ky	365	27	-	-	HYPH
cord-276456-oa6hh7ky	365	28	mediated	mediate	VBN
cord-276456-oa6hh7ky	365	29	disassembly	disassembly	NN
cord-276456-oa6hh7ky	365	30	Testing	test	VBG
cord-276456-oa6hh7ky	365	31	the	the	DT
cord-276456-oa6hh7ky	365	32	3Q:1R	3Q:1R	NNP
cord-276456-oa6hh7ky	365	33	'	'	''
cord-276456-oa6hh7ky	365	34	'	'	``
cord-276456-oa6hh7ky	365	35	rule	rule	NN
cord-276456-oa6hh7ky	365	36	'	'	''
cord-276456-oa6hh7ky	365	37	'	'	''
cord-276456-oa6hh7ky	366	1	:	:	:
cord-276456-oa6hh7ky	366	2	mutational	mutational	JJ
cord-276456-oa6hh7ky	366	3	analysis	analysis	NN
cord-276456-oa6hh7ky	366	4	of	of	IN
cord-276456-oa6hh7ky	366	5	the	the	DT
cord-276456-oa6hh7ky	366	6	ionic	ionic	NNP
cord-276456-oa6hh7ky	366	7	'	'	POS
cord-276456-oa6hh7ky	366	8	'	'	``
cord-276456-oa6hh7ky	366	9	zero	zero	CD
cord-276456-oa6hh7ky	366	10	'	'	''
cord-276456-oa6hh7ky	366	11	'	'	''
cord-276456-oa6hh7ky	366	12	layer	layer	NN
cord-276456-oa6hh7ky	366	13	in	in	IN
cord-276456-oa6hh7ky	366	14	the	the	DT
cord-276456-oa6hh7ky	366	15	yeast	yeast	NN
cord-276456-oa6hh7ky	366	16	exocytic	exocytic	NN
cord-276456-oa6hh7ky	366	17	SNARE	snare	VBP
cord-276456-oa6hh7ky	366	18	complex	complex	NN
cord-276456-oa6hh7ky	366	19	reveals	reveal	VBZ
cord-276456-oa6hh7ky	366	20	no	no	DT
cord-276456-oa6hh7ky	366	21	requirement	requirement	NN
cord-276456-oa6hh7ky	366	22	for	for	IN
cord-276456-oa6hh7ky	366	23	arginine	arginine	NN
cord-276456-oa6hh7ky	366	24	Exocytotic	Exocytotic	NNP
cord-276456-oa6hh7ky	366	25	mechanism	mechanism	NN
cord-276456-oa6hh7ky	366	26	studied	study	VBN
cord-276456-oa6hh7ky	366	27	by	by	IN
cord-276456-oa6hh7ky	366	28	truncated	truncated	JJ
cord-276456-oa6hh7ky	366	29	and	and	CC
cord-276456-oa6hh7ky	366	30	zero	zero	CD
cord-276456-oa6hh7ky	366	31	layer	layer	NN
cord-276456-oa6hh7ky	366	32	mutants	mutant	NNS
cord-276456-oa6hh7ky	366	33	of	of	IN
cord-276456-oa6hh7ky	366	34	the	the	DT
cord-276456-oa6hh7ky	366	35	C	c	NN
cord-276456-oa6hh7ky	366	36	-	-	HYPH
cord-276456-oa6hh7ky	366	37	terminus	terminus	NN
cord-276456-oa6hh7ky	366	38	of	of	IN
cord-276456-oa6hh7ky	366	39	SNAP-25	SNAP-25	NNP
cord-276456-oa6hh7ky	366	40	Dynamic	dynamic	JJ
cord-276456-oa6hh7ky	366	41	structure	structure	NN
cord-276456-oa6hh7ky	366	42	of	of	IN
cord-276456-oa6hh7ky	366	43	lipid	lipid	NN
cord-276456-oa6hh7ky	366	44	-	-	HYPH
cord-276456-oa6hh7ky	366	45	bound	bind	VBN
cord-276456-oa6hh7ky	366	46	synaptobrevin	synaptobrevin	NNP
cord-276456-oa6hh7ky	366	47	suggests	suggest	VBZ
cord-276456-oa6hh7ky	366	48	a	a	DT
cord-276456-oa6hh7ky	366	49	nucleationpropagation	nucleationpropagation	NN
cord-276456-oa6hh7ky	366	50	mechanism	mechanism	NN
cord-276456-oa6hh7ky	366	51	for	for	IN
cord-276456-oa6hh7ky	366	52	trans	trans	JJ
cord-276456-oa6hh7ky	366	53	-	-	JJ
cord-276456-oa6hh7ky	366	54	SNARE	snare	VB
cord-276456-oa6hh7ky	366	55	complex	complex	JJ
cord-276456-oa6hh7ky	366	56	formation	formation	NN
cord-276456-oa6hh7ky	367	1	The	the	DT
cord-276456-oa6hh7ky	367	2	SNARE	snare	NN
cord-276456-oa6hh7ky	367	3	complex	complex	NN
cord-276456-oa6hh7ky	367	4	from	from	IN
cord-276456-oa6hh7ky	367	5	yeast	yeast	NN
cord-276456-oa6hh7ky	367	6	is	be	VBZ
cord-276456-oa6hh7ky	367	7	partially	partially	RB
cord-276456-oa6hh7ky	367	8	unstructured	unstructured	JJ
cord-276456-oa6hh7ky	367	9	on	on	IN
cord-276456-oa6hh7ky	367	10	the	the	DT
cord-276456-oa6hh7ky	367	11	membrane	membrane	NN
cord-276456-oa6hh7ky	367	12	Structural	structural	JJ
cord-276456-oa6hh7ky	367	13	basis	basis	NN
cord-276456-oa6hh7ky	367	14	for	for	IN
cord-276456-oa6hh7ky	367	15	the	the	DT
cord-276456-oa6hh7ky	367	16	inhibitory	inhibitory	JJ
cord-276456-oa6hh7ky	367	17	role	role	NN
cord-276456-oa6hh7ky	367	18	of	of	IN
cord-276456-oa6hh7ky	367	19	tomosyn	tomosyn	NN
cord-276456-oa6hh7ky	367	20	in	in	IN
cord-276456-oa6hh7ky	367	21	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	367	22	Transmembrane	Transmembrane	NNP
cord-276456-oa6hh7ky	367	23	segments	segment	NNS
cord-276456-oa6hh7ky	367	24	of	of	IN
cord-276456-oa6hh7ky	367	25	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	367	26	line	line	NN
cord-276456-oa6hh7ky	368	1	the	the	DT
cord-276456-oa6hh7ky	368	2	fusion	fusion	NN
cord-276456-oa6hh7ky	368	3	pore	pore	NN
cord-276456-oa6hh7ky	368	4	of	of	IN
cord-276456-oa6hh7ky	368	5	Ca	Ca	NNP
cord-276456-oa6hh7ky	368	6	2	2	CD
cord-276456-oa6hh7ky	368	7	þ	þ	CD
cord-276456-oa6hh7ky	368	8	-triggered	-triggered	CD
cord-276456-oa6hh7ky	368	9	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	368	10	Single	single	JJ
cord-276456-oa6hh7ky	368	11	vesicle	vesicle	NN
cord-276456-oa6hh7ky	368	12	millisecond	millisecond	NN
cord-276456-oa6hh7ky	368	13	fusion	fusion	NN
cord-276456-oa6hh7ky	368	14	kinetics	kinetics	NN
cord-276456-oa6hh7ky	368	15	reveals	reveal	VBZ
cord-276456-oa6hh7ky	368	16	number	number	NN
cord-276456-oa6hh7ky	368	17	of	of	IN
cord-276456-oa6hh7ky	368	18	SNARE	snare	NN
cord-276456-oa6hh7ky	368	19	complexes	complex	NNS
cord-276456-oa6hh7ky	368	20	optimal	optimal	JJ
cord-276456-oa6hh7ky	368	21	for	for	IN
cord-276456-oa6hh7ky	368	22	fast	fast	JJ
cord-276456-oa6hh7ky	368	23	SNARE	snare	NN
cord-276456-oa6hh7ky	368	24	-	-	HYPH
cord-276456-oa6hh7ky	368	25	mediated	mediate	VBN
cord-276456-oa6hh7ky	368	26	membrane	membrane	NN
cord-276456-oa6hh7ky	368	27	fusion	fusion	NN
cord-276456-oa6hh7ky	368	28	Docking	docking	NN
cord-276456-oa6hh7ky	368	29	and	and	CC
cord-276456-oa6hh7ky	368	30	fast	fast	JJ
cord-276456-oa6hh7ky	368	31	fusion	fusion	NN
cord-276456-oa6hh7ky	368	32	of	of	IN
cord-276456-oa6hh7ky	368	33	synaptobrevin	synaptobrevin	NNP
cord-276456-oa6hh7ky	368	34	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	368	35	depends	depend	VBZ
cord-276456-oa6hh7ky	368	36	on	on	IN
cord-276456-oa6hh7ky	368	37	the	the	DT
cord-276456-oa6hh7ky	368	38	lipid	lipid	NN
cord-276456-oa6hh7ky	368	39	compositions	composition	NNS
cord-276456-oa6hh7ky	368	40	of	of	IN
cord-276456-oa6hh7ky	368	41	the	the	DT
cord-276456-oa6hh7ky	368	42	vesicle	vesicle	NN
cord-276456-oa6hh7ky	368	43	and	and	CC
cord-276456-oa6hh7ky	368	44	the	the	DT
cord-276456-oa6hh7ky	368	45	acceptor	acceptor	NN
cord-276456-oa6hh7ky	368	46	SNARE	snare	VB
cord-276456-oa6hh7ky	368	47	complex	complex	RB
cord-276456-oa6hh7ky	368	48	-	-	HYPH
cord-276456-oa6hh7ky	368	49	containing	contain	VBG
cord-276456-oa6hh7ky	368	50	target	target	NN
cord-276456-oa6hh7ky	368	51	membrane	membrane	NN
cord-276456-oa6hh7ky	368	52	Reconstitution	reconstitution	NN
cord-276456-oa6hh7ky	368	53	of	of	IN
cord-276456-oa6hh7ky	368	54	Rab	Rab	NNP
cord-276456-oa6hh7ky	368	55	-	-	:
cord-276456-oa6hh7ky	368	56	and	and	CC
cord-276456-oa6hh7ky	368	57	SNARE	snare	VB
cord-276456-oa6hh7ky	368	58	-	-	HYPH
cord-276456-oa6hh7ky	368	59	dependent	dependent	JJ
cord-276456-oa6hh7ky	368	60	membrane	membrane	NN
cord-276456-oa6hh7ky	368	61	fusion	fusion	NN
cord-276456-oa6hh7ky	368	62	by	by	IN
cord-276456-oa6hh7ky	368	63	synthetic	synthetic	JJ
cord-276456-oa6hh7ky	368	64	endosomes	endosome	NNS
cord-276456-oa6hh7ky	368	65	Single	single	JJ
cord-276456-oa6hh7ky	368	66	-	-	HYPH
cord-276456-oa6hh7ky	368	67	molecule	molecule	NN
cord-276456-oa6hh7ky	368	68	studies	study	NNS
cord-276456-oa6hh7ky	368	69	of	of	IN
cord-276456-oa6hh7ky	368	70	SNARE	snare	VB
cord-276456-oa6hh7ky	368	71	complex	complex	JJ
cord-276456-oa6hh7ky	368	72	assembly	assembly	NN
cord-276456-oa6hh7ky	368	73	reveal	reveal	VBP
cord-276456-oa6hh7ky	368	74	parallel	parallel	JJ
cord-276456-oa6hh7ky	368	75	and	and	CC
cord-276456-oa6hh7ky	368	76	antiparallel	antiparallel	NN
cord-276456-oa6hh7ky	368	77	configurations	configuration	NNS
cord-276456-oa6hh7ky	368	78	Structural	structural	JJ
cord-276456-oa6hh7ky	368	79	transitions	transition	NNS
cord-276456-oa6hh7ky	368	80	in	in	IN
cord-276456-oa6hh7ky	368	81	the	the	DT
cord-276456-oa6hh7ky	368	82	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	368	83	SNARE	snare	VB
cord-276456-oa6hh7ky	368	84	complex	complex	JJ
cord-276456-oa6hh7ky	368	85	during	during	IN
cord-276456-oa6hh7ky	368	86	Ca	Ca	NNP
cord-276456-oa6hh7ky	368	87	2	2	CD
cord-276456-oa6hh7ky	368	88	þ	þ	NNP
cord-276456-oa6hh7ky	368	89	-triggered	-triggered	CD
cord-276456-oa6hh7ky	368	90	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	368	91	Novel	Novel	NNP
cord-276456-oa6hh7ky	368	92	targets	target	NNS
cord-276456-oa6hh7ky	368	93	and	and	CC
cord-276456-oa6hh7ky	368	94	catalytic	catalytic	JJ
cord-276456-oa6hh7ky	368	95	activities	activity	NNS
cord-276456-oa6hh7ky	368	96	of	of	IN
cord-276456-oa6hh7ky	368	97	bacterial	bacterial	JJ
cord-276456-oa6hh7ky	368	98	protein	protein	NN
cord-276456-oa6hh7ky	368	99	toxins	toxin	NNS
cord-276456-oa6hh7ky	368	100	Receptor	receptor	NN
cord-276456-oa6hh7ky	368	101	and	and	CC
cord-276456-oa6hh7ky	368	102	substrate	substrate	NN
cord-276456-oa6hh7ky	368	103	interactions	interaction	NNS
cord-276456-oa6hh7ky	368	104	of	of	IN
cord-276456-oa6hh7ky	368	105	clostridial	clostridial	JJ
cord-276456-oa6hh7ky	368	106	neurotoxins	neurotoxin	NNS
cord-276456-oa6hh7ky	368	107	X	x	NN
cord-276456-oa6hh7ky	368	108	-	-	NN
cord-276456-oa6hh7ky	368	109	ray	ray	JJ
cord-276456-oa6hh7ky	368	110	structure	structure	NN
cord-276456-oa6hh7ky	368	111	of	of	IN
cord-276456-oa6hh7ky	368	112	a	a	DT
cord-276456-oa6hh7ky	368	113	neuronal	neuronal	JJ
cord-276456-oa6hh7ky	368	114	complexin	complexin	JJ
cord-276456-oa6hh7ky	368	115	-	-	HYPH
cord-276456-oa6hh7ky	368	116	SNARE	snare	VBP
cord-276456-oa6hh7ky	368	117	complex	complex	NN
cord-276456-oa6hh7ky	368	118	from	from	IN
cord-276456-oa6hh7ky	368	119	squid	squid	JJ
cord-276456-oa6hh7ky	368	120	Three	three	CD
cord-276456-oa6hh7ky	368	121	-	-	HYPH
cord-276456-oa6hh7ky	368	122	dimensional	dimensional	JJ
cord-276456-oa6hh7ky	368	123	structure	structure	NN
cord-276456-oa6hh7ky	368	124	of	of	IN
cord-276456-oa6hh7ky	368	125	the	the	DT
cord-276456-oa6hh7ky	368	126	complexin	complexin	JJ
cord-276456-oa6hh7ky	368	127	/	/	SYM
cord-276456-oa6hh7ky	368	128	SNARE	snare	VB
cord-276456-oa6hh7ky	368	129	complex	complex	JJ
cord-276456-oa6hh7ky	369	1	The	the	DT
cord-276456-oa6hh7ky	369	2	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	369	3	vesicle	vesicle	NN
cord-276456-oa6hh7ky	369	4	protein	protein	NN
cord-276456-oa6hh7ky	369	5	CSP	CSP	NNP
cord-276456-oa6hh7ky	369	6	alpha	alpha	NN
cord-276456-oa6hh7ky	369	7	prevents	prevent	VBZ
cord-276456-oa6hh7ky	369	8	presynaptic	presynaptic	JJ
cord-276456-oa6hh7ky	369	9	degeneration	degeneration	NN
cord-276456-oa6hh7ky	369	10	Ddi1	Ddi1	NNP
cord-276456-oa6hh7ky	369	11	,	,	,
cord-276456-oa6hh7ky	369	12	a	a	DT
cord-276456-oa6hh7ky	369	13	eukaryotic	eukaryotic	JJ
cord-276456-oa6hh7ky	369	14	protein	protein	NN
cord-276456-oa6hh7ky	369	15	with	with	IN
cord-276456-oa6hh7ky	369	16	the	the	DT
cord-276456-oa6hh7ky	369	17	retroviral	retroviral	JJ
cord-276456-oa6hh7ky	369	18	protease	protease	NN
cord-276456-oa6hh7ky	369	19	fold	fold	VBP
cord-276456-oa6hh7ky	369	20	Different	different	JJ
cord-276456-oa6hh7ky	369	21	domains	domain	NNS
cord-276456-oa6hh7ky	369	22	of	of	IN
cord-276456-oa6hh7ky	369	23	the	the	DT
cord-276456-oa6hh7ky	369	24	UBL	UBL	NNP
cord-276456-oa6hh7ky	369	25	-	-	HYPH
cord-276456-oa6hh7ky	369	26	UBA	UBA	NNP
cord-276456-oa6hh7ky	369	27	ubiquitin	ubiquitin	NN
cord-276456-oa6hh7ky	369	28	receptor	receptor	NN
cord-276456-oa6hh7ky	369	29	,	,	,
cord-276456-oa6hh7ky	369	30	Ddi1	Ddi1	NNP
cord-276456-oa6hh7ky	369	31	/	/	SYM
cord-276456-oa6hh7ky	369	32	Vsm1	Vsm1	NNP
cord-276456-oa6hh7ky	369	33	,	,	,
cord-276456-oa6hh7ky	369	34	are	be	VBP
cord-276456-oa6hh7ky	369	35	involved	involve	VBN
cord-276456-oa6hh7ky	369	36	in	in	IN
cord-276456-oa6hh7ky	369	37	its	-PRON-	PRP$
cord-276456-oa6hh7ky	369	38	multiple	multiple	JJ
cord-276456-oa6hh7ky	369	39	cellular	cellular	JJ
cord-276456-oa6hh7ky	369	40	roles	role	NNS
cord-276456-oa6hh7ky	369	41	A	a	DT
cord-276456-oa6hh7ky	369	42	structure	structure	NN
cord-276456-oa6hh7ky	369	43	-	-	HYPH
cord-276456-oa6hh7ky	369	44	based	base	VBN
cord-276456-oa6hh7ky	369	45	mechanism	mechanism	NN
cord-276456-oa6hh7ky	369	46	for	for	IN
cord-276456-oa6hh7ky	369	47	vesicle	vesicle	NN
cord-276456-oa6hh7ky	369	48	capture	capture	NN
cord-276456-oa6hh7ky	369	49	by	by	IN
cord-276456-oa6hh7ky	369	50	the	the	DT
cord-276456-oa6hh7ky	369	51	multisubunit	multisubunit	NN
cord-276456-oa6hh7ky	369	52	tethering	tethering	NN
cord-276456-oa6hh7ky	369	53	complex	complex	NNP
cord-276456-oa6hh7ky	370	1	Dsl1	dsl1	JJ
cord-276456-oa6hh7ky	371	1	The	the	DT
cord-276456-oa6hh7ky	371	2	Rab5	Rab5	NNP
cord-276456-oa6hh7ky	371	3	effector	effector	NN
cord-276456-oa6hh7ky	371	4	EEA1	EEA1	NNP
cord-276456-oa6hh7ky	371	5	interacts	interact	VBZ
cord-276456-oa6hh7ky	371	6	directly	directly	RB
cord-276456-oa6hh7ky	371	7	with	with	IN
cord-276456-oa6hh7ky	371	8	syntaxin-6	syntaxin-6	NNP
cord-276456-oa6hh7ky	371	9	Involvement	Involvement	NNP
cord-276456-oa6hh7ky	371	10	of	of	IN
cord-276456-oa6hh7ky	371	11	LMA1	LMA1	NNP
cord-276456-oa6hh7ky	371	12	and	and	CC
cord-276456-oa6hh7ky	371	13	GATE-16	GATE-16	NNP
cord-276456-oa6hh7ky	371	14	family	family	NN
cord-276456-oa6hh7ky	371	15	members	member	NNS
cord-276456-oa6hh7ky	371	16	in	in	IN
cord-276456-oa6hh7ky	371	17	intracellular	intracellular	JJ
cord-276456-oa6hh7ky	371	18	membrane	membrane	NN
cord-276456-oa6hh7ky	371	19	dynamics	dynamic	NNS
cord-276456-oa6hh7ky	371	20	Structure	Structure	NNP
cord-276456-oa6hh7ky	371	21	of	of	IN
cord-276456-oa6hh7ky	371	22	GATE-16	GATE-16	NNP
cord-276456-oa6hh7ky	371	23	,	,	,
cord-276456-oa6hh7ky	371	24	membrane	membrane	NN
cord-276456-oa6hh7ky	371	25	transport	transport	NN
cord-276456-oa6hh7ky	371	26	modulator	modulator	NN
cord-276456-oa6hh7ky	371	27	and	and	CC
cord-276456-oa6hh7ky	371	28	mammalian	mammalian	JJ
cord-276456-oa6hh7ky	371	29	ortholog	ortholog	NN
cord-276456-oa6hh7ky	371	30	of	of	IN
cord-276456-oa6hh7ky	371	31	autophagocytosis	autophagocytosis	NNP
cord-276456-oa6hh7ky	371	32	factor	factor	NN
cord-276456-oa6hh7ky	372	1	Aut7p	Aut7p	NNPS
cord-276456-oa6hh7ky	372	2	Intracellular	Intracellular	NNP
cord-276456-oa6hh7ky	372	3	bacteria	bacteria	NNS
cord-276456-oa6hh7ky	372	4	encode	encode	VB
cord-276456-oa6hh7ky	372	5	inhibitory	inhibitory	JJ
cord-276456-oa6hh7ky	372	6	SNARE	snare	NN
cord-276456-oa6hh7ky	372	7	-	-	HYPH
cord-276456-oa6hh7ky	372	8	like	like	JJ
cord-276456-oa6hh7ky	372	9	proteins	protein	NNS
cord-276456-oa6hh7ky	373	1	A	a	DT
cord-276456-oa6hh7ky	373	2	phorbol	phorbol	NNP
cord-276456-oa6hh7ky	373	3	ester	ester	NN
cord-276456-oa6hh7ky	373	4	/	/	SYM
cord-276456-oa6hh7ky	373	5	diacylglycerol	diacylglycerol	NN
cord-276456-oa6hh7ky	373	6	-	-	HYPH
cord-276456-oa6hh7ky	373	7	binding	bind	VBG
cord-276456-oa6hh7ky	373	8	protein	protein	NN
cord-276456-oa6hh7ky	373	9	encoded	encode	VBN
cord-276456-oa6hh7ky	373	10	by	by	IN
cord-276456-oa6hh7ky	373	11	the	the	DT
cord-276456-oa6hh7ky	373	12	unc-13	unc-13	NNP
cord-276456-oa6hh7ky	373	13	gene	gene	NN
cord-276456-oa6hh7ky	373	14	of	of	IN
cord-276456-oa6hh7ky	373	15	Caenorhabditis	Caenorhabditis	NNP
cord-276456-oa6hh7ky	373	16	elegans	elegan	VBZ
cord-276456-oa6hh7ky	373	17	An	an	DT
cord-276456-oa6hh7ky	373	18	open	open	JJ
cord-276456-oa6hh7ky	373	19	form	form	NN
cord-276456-oa6hh7ky	373	20	of	of	IN
cord-276456-oa6hh7ky	373	21	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	373	22	bypasses	bypass	VBZ
cord-276456-oa6hh7ky	373	23	the	the	DT
cord-276456-oa6hh7ky	373	24	requirement	requirement	NN
cord-276456-oa6hh7ky	373	25	for	for	IN
cord-276456-oa6hh7ky	373	26	UNC-13	UNC-13	NNP
cord-276456-oa6hh7ky	373	27	in	in	IN
cord-276456-oa6hh7ky	373	28	vesicle	vesicle	NN
cord-276456-oa6hh7ky	373	29	priming	prime	VBG
cord-276456-oa6hh7ky	373	30	Modular	modular	JJ
cord-276456-oa6hh7ky	373	31	architecture	architecture	NN
cord-276456-oa6hh7ky	373	32	of	of	IN
cord-276456-oa6hh7ky	373	33	Munc	Munc	NNP
cord-276456-oa6hh7ky	373	34	13	13	CD
cord-276456-oa6hh7ky	373	35	/	/	SYM
cord-276456-oa6hh7ky	373	36	calmodulin	calmodulin	NN
cord-276456-oa6hh7ky	373	37	complexes	complex	NNS
cord-276456-oa6hh7ky	373	38	:	:	:
cord-276456-oa6hh7ky	373	39	dual	dual	JJ
cord-276456-oa6hh7ky	373	40	regulation	regulation	NN
cord-276456-oa6hh7ky	373	41	by	by	IN
cord-276456-oa6hh7ky	373	42	Ca	Ca	NNP
cord-276456-oa6hh7ky	373	43	2	2	CD
cord-276456-oa6hh7ky	373	44	þ	þ	NN
cord-276456-oa6hh7ky	373	45	and	and	CC
cord-276456-oa6hh7ky	373	46	possibility	possibility	NN
cord-276456-oa6hh7ky	373	47	function	function	NN
cord-276456-oa6hh7ky	373	48	in	in	IN
cord-276456-oa6hh7ky	373	49	short	short	JJ
cord-276456-oa6hh7ky	373	50	-	-	HYPH
cord-276456-oa6hh7ky	373	51	term	term	NN
cord-276456-oa6hh7ky	373	52	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	373	53	plasticity	plasticity	NN
cord-276456-oa6hh7ky	373	54	Structural	structural	JJ
cord-276456-oa6hh7ky	373	55	basis	basis	NN
cord-276456-oa6hh7ky	373	56	for	for	IN
cord-276456-oa6hh7ky	373	57	a	a	DT
cord-276456-oa6hh7ky	373	58	Munc13	munc13	CD
cord-276456-oa6hh7ky	373	59	-	-	HYPH
cord-276456-oa6hh7ky	373	60	1	1	CD
cord-276456-oa6hh7ky	373	61	homodimer	homodimer	NN
cord-276456-oa6hh7ky	373	62	to	to	IN
cord-276456-oa6hh7ky	373	63	Munc13	munc13	CD
cord-276456-oa6hh7ky	373	64	-	-	HYPH
cord-276456-oa6hh7ky	373	65	1	1	CD
cord-276456-oa6hh7ky	373	66	/	/	SYM
cord-276456-oa6hh7ky	373	67	RIM	rim	NN
cord-276456-oa6hh7ky	373	68	heterodimer	heterodimer	NN
cord-276456-oa6hh7ky	373	69	switch	switch	VBP
cord-276456-oa6hh7ky	373	70	Cellular	cellular	JJ
cord-276456-oa6hh7ky	373	71	functions	function	NNS
cord-276456-oa6hh7ky	373	72	of	of	IN
cord-276456-oa6hh7ky	373	73	NSF	NSF	NNP
cord-276456-oa6hh7ky	373	74	:	:	:
cord-276456-oa6hh7ky	373	75	not	not	RB
cord-276456-oa6hh7ky	373	76	just	just	RB
cord-276456-oa6hh7ky	373	77	SNAPs	snaps	VB
cord-276456-oa6hh7ky	373	78	and	and	CC
cord-276456-oa6hh7ky	373	79	SNAREs	SNAREs	NNP
cord-276456-oa6hh7ky	373	80	Isolation	isolation	NN
cord-276456-oa6hh7ky	373	81	and	and	CC
cord-276456-oa6hh7ky	373	82	characterization	characterization	NN
cord-276456-oa6hh7ky	373	83	of	of	IN
cord-276456-oa6hh7ky	373	84	a	a	DT
cord-276456-oa6hh7ky	373	85	dual	dual	JJ
cord-276456-oa6hh7ky	373	86	prenylated	prenylate	VBN
cord-276456-oa6hh7ky	373	87	Rab	Rab	NNP
cord-276456-oa6hh7ky	373	88	and	and	CC
cord-276456-oa6hh7ky	373	89	VAMP2	vamp2	NN
cord-276456-oa6hh7ky	373	90	receptor	receptor	NN
cord-276456-oa6hh7ky	373	91	Structural	structural	JJ
cord-276456-oa6hh7ky	373	92	basis	basis	NN
cord-276456-oa6hh7ky	373	93	of	of	IN
cord-276456-oa6hh7ky	373	94	Rab	Rab	NNP
cord-276456-oa6hh7ky	373	95	effector	effector	NN
cord-276456-oa6hh7ky	373	96	specificity	specificity	NN
cord-276456-oa6hh7ky	373	97	:	:	:
cord-276456-oa6hh7ky	373	98	crystal	crystal	NN
cord-276456-oa6hh7ky	373	99	structure	structure	NN
cord-276456-oa6hh7ky	373	100	of	of	IN
cord-276456-oa6hh7ky	373	101	the	the	DT
cord-276456-oa6hh7ky	373	102	small	small	JJ
cord-276456-oa6hh7ky	373	103	G	G	NNP
cord-276456-oa6hh7ky	373	104	protein	protein	NN
cord-276456-oa6hh7ky	373	105	Rab3A	rab3a	NN
cord-276456-oa6hh7ky	373	106	complexed	complexe	VBN
cord-276456-oa6hh7ky	373	107	with	with	IN
cord-276456-oa6hh7ky	373	108	the	the	DT
cord-276456-oa6hh7ky	373	109	effector	effector	JJ
cord-276456-oa6hh7ky	373	110	domain	domain	NN
cord-276456-oa6hh7ky	373	111	of	of	IN
cord-276456-oa6hh7ky	373	112	rabphilin-3A	rabphilin-3A	NNP
cord-276456-oa6hh7ky	373	113	A	a	DT
cord-276456-oa6hh7ky	373	114	novel	novel	JJ
cord-276456-oa6hh7ky	373	115	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	373	116	6-interacting	6-interacting	CD
cord-276456-oa6hh7ky	374	1	protein	protein	NN
cord-276456-oa6hh7ky	374	2	,	,	,
cord-276456-oa6hh7ky	374	3	SHIP164	SHIP164	NNP
cord-276456-oa6hh7ky	374	4	,	,	,
cord-276456-oa6hh7ky	374	5	regulates	regulate	VBZ
cord-276456-oa6hh7ky	374	6	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	374	7	6-dependent	6-dependent	CD
cord-276456-oa6hh7ky	375	1	sorting	sort	VBG
cord-276456-oa6hh7ky	375	2	from	from	IN
cord-276456-oa6hh7ky	375	3	early	early	JJ
cord-276456-oa6hh7ky	375	4	endosomes	endosome	NNS
cord-276456-oa6hh7ky	376	1	Synaptic	synaptic	JJ
cord-276456-oa6hh7ky	376	2	vesicle	vesicle	NN
cord-276456-oa6hh7ky	376	3	fusion	fusion	NN
cord-276456-oa6hh7ky	376	4	complex	complex	NN
cord-276456-oa6hh7ky	376	5	contains	contain	VBZ
cord-276456-oa6hh7ky	376	6	unc-18	unc-18	NNP
cord-276456-oa6hh7ky	376	7	homologue	homologue	NN
cord-276456-oa6hh7ky	376	8	bound	bind	VBN
cord-276456-oa6hh7ky	376	9	to	to	IN
cord-276456-oa6hh7ky	376	10	syntaxin	syntaxin	NNP
cord-276456-oa6hh7ky	376	11	Specificity	Specificity	NNP
cord-276456-oa6hh7ky	376	12	and	and	CC
cord-276456-oa6hh7ky	376	13	regulation	regulation	NN
cord-276456-oa6hh7ky	376	14	of	of	IN
cord-276456-oa6hh7ky	376	15	a	a	DT
cord-276456-oa6hh7ky	376	16	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	376	17	vesicle	vesicle	NN
cord-276456-oa6hh7ky	376	18	docking	docking	NN
cord-276456-oa6hh7ky	376	19	complex	complex	NN
cord-276456-oa6hh7ky	376	20	Sec1p	Sec1p	NNP
cord-276456-oa6hh7ky	376	21	binds	bind	VBZ
cord-276456-oa6hh7ky	376	22	to	to	TO
cord-276456-oa6hh7ky	376	23	SNARE	snare	VB
cord-276456-oa6hh7ky	376	24	complexes	complex	NNS
cord-276456-oa6hh7ky	376	25	and	and	CC
cord-276456-oa6hh7ky	376	26	concentrates	concentrate	VBZ
cord-276456-oa6hh7ky	376	27	at	at	IN
cord-276456-oa6hh7ky	376	28	sites	site	NNS
cord-276456-oa6hh7ky	376	29	of	of	IN
cord-276456-oa6hh7ky	376	30	secretion	secretion	NN
cord-276456-oa6hh7ky	376	31	Tomosyn	Tomosyn	NNP
cord-276456-oa6hh7ky	376	32	:	:	:
cord-276456-oa6hh7ky	376	33	a	a	DT
cord-276456-oa6hh7ky	376	34	syntaxin-1-binding	syntaxin-1-binding	NNP
cord-276456-oa6hh7ky	376	35	protein	protein	NN
cord-276456-oa6hh7ky	376	36	that	that	WDT
cord-276456-oa6hh7ky	376	37	forms	form	VBZ
cord-276456-oa6hh7ky	376	38	a	a	DT
cord-276456-oa6hh7ky	376	39	novel	novel	NN
cord-276456-oa6hh7ky	376	40	complex	complex	NN
cord-276456-oa6hh7ky	376	41	in	in	IN
cord-276456-oa6hh7ky	376	42	the	the	DT
cord-276456-oa6hh7ky	376	43	neurotransmitter	neurotransmitter	NN
cord-276456-oa6hh7ky	376	44	release	release	NN
cord-276456-oa6hh7ky	376	45	process	process	NN
cord-276456-oa6hh7ky	376	46	Structure	Structure	NNP
cord-276456-oa6hh7ky	376	47	of	of	IN
cord-276456-oa6hh7ky	376	48	the	the	DT
cord-276456-oa6hh7ky	376	49	yeast	yeast	NN
cord-276456-oa6hh7ky	376	50	polarity	polarity	NN
cord-276456-oa6hh7ky	376	51	protein	protein	NN
cord-276456-oa6hh7ky	376	52	Sro7	Sro7	NNP
cord-276456-oa6hh7ky	376	53	reveals	reveal	VBZ
cord-276456-oa6hh7ky	376	54	a	a	DT
cord-276456-oa6hh7ky	376	55	SNARE	snare	NN
cord-276456-oa6hh7ky	376	56	regulatory	regulatory	JJ
cord-276456-oa6hh7ky	376	57	mechanism	mechanism	NN
cord-276456-oa6hh7ky	376	58	Amisyn	Amisyn	NNP
cord-276456-oa6hh7ky	376	59	,	,	,
cord-276456-oa6hh7ky	376	60	a	a	DT
cord-276456-oa6hh7ky	376	61	novel	novel	JJ
cord-276456-oa6hh7ky	376	62	syntaxin	syntaxin	NN
cord-276456-oa6hh7ky	376	63	-	-	HYPH
cord-276456-oa6hh7ky	376	64	binding	bind	VBG
cord-276456-oa6hh7ky	376	65	protein	protein	NN
cord-276456-oa6hh7ky	376	66	that	that	WDT
cord-276456-oa6hh7ky	376	67	may	may	MD
cord-276456-oa6hh7ky	376	68	regulate	regulate	VB
cord-276456-oa6hh7ky	376	69	SNARE	snare	VB
cord-276456-oa6hh7ky	376	70	complex	complex	JJ
cord-276456-oa6hh7ky	376	71	assembly	assembly	NN
cord-276456-oa6hh7ky	376	72	SNAP	snap	VBP
cord-276456-oa6hh7ky	376	73	family	family	NN
cord-276456-oa6hh7ky	376	74	of	of	IN
cord-276456-oa6hh7ky	376	75	NSF	NSF	NNP
cord-276456-oa6hh7ky	376	76	attachment	attachment	NN
cord-276456-oa6hh7ky	376	77	proteins	protein	NNS
cord-276456-oa6hh7ky	377	1	includes	include	VBZ
cord-276456-oa6hh7ky	377	2	a	a	DT
cord-276456-oa6hh7ky	377	3	brain	brain	NN
cord-276456-oa6hh7ky	377	4	-	-	HYPH
cord-276456-oa6hh7ky	377	5	specific	specific	JJ
cord-276456-oa6hh7ky	377	6	isoform	isoform	NN
cord-276456-oa6hh7ky	378	1	The	the	DT
cord-276456-oa6hh7ky	378	2	yeast	yeast	NN
cord-276456-oa6hh7ky	378	3	SEC17	sec17	JJ
cord-276456-oa6hh7ky	378	4	gene	gene	NN
cord-276456-oa6hh7ky	378	5	product	product	NN
cord-276456-oa6hh7ky	378	6	is	be	VBZ
cord-276456-oa6hh7ky	378	7	functionally	functionally	RB
cord-276456-oa6hh7ky	378	8	equivalent	equivalent	JJ
cord-276456-oa6hh7ky	378	9	to	to	IN
cord-276456-oa6hh7ky	378	10	mammalian	mammalian	JJ
cord-276456-oa6hh7ky	378	11	alpha	alpha	NN
cord-276456-oa6hh7ky	378	12	-	-	HYPH
cord-276456-oa6hh7ky	378	13	SNAP	snap	JJ
cord-276456-oa6hh7ky	378	14	protein	protein	NN
cord-276456-oa6hh7ky	378	15	Doc2b	doc2b	NN
cord-276456-oa6hh7ky	378	16	is	be	VBZ
cord-276456-oa6hh7ky	378	17	a	a	DT
cord-276456-oa6hh7ky	378	18	high	high	JJ
cord-276456-oa6hh7ky	378	19	affinity	affinity	NN
cord-276456-oa6hh7ky	379	1	Ca	ca	NN
cord-276456-oa6hh7ky	379	2	2	2	CD
cord-276456-oa6hh7ky	379	3	þ	þ	CD
cord-276456-oa6hh7ky	379	4	sensor	sensor	NN
cord-276456-oa6hh7ky	379	5	for	for	IN
cord-276456-oa6hh7ky	379	6	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	379	7	neurotransmitter	neurotransmitter	NN
cord-276456-oa6hh7ky	379	8	release	release	NN
cord-276456-oa6hh7ky	380	1	Synaptotagmin-	Synaptotagmin-	NNP
cord-276456-oa6hh7ky	381	1	Ca	ca	NN
cord-276456-oa6hh7ky	381	2	2	2	CD
cord-276456-oa6hh7ky	381	3	+	+	SYM
cord-276456-oa6hh7ky	381	4	triggers	trigger	VBZ
cord-276456-oa6hh7ky	381	5	two	two	CD
cord-276456-oa6hh7ky	381	6	sequential	sequential	JJ
cord-276456-oa6hh7ky	381	7	steps	step	NNS
cord-276456-oa6hh7ky	381	8	in	in	IN
cord-276456-oa6hh7ky	381	9	regulated	regulate	VBN
cord-276456-oa6hh7ky	381	10	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	381	11	in	in	IN
cord-276456-oa6hh7ky	381	12	rat	rat	NN
cord-276456-oa6hh7ky	381	13	PC12	PC12	NNP
cord-276456-oa6hh7ky	381	14	cells	cell	NNS
cord-276456-oa6hh7ky	381	15	:	:	:
cord-276456-oa6hh7ky	381	16	fusion	fusion	NN
cord-276456-oa6hh7ky	381	17	pore	pore	NN
cord-276456-oa6hh7ky	381	18	opening	opening	NN
cord-276456-oa6hh7ky	381	19	and	and	CC
cord-276456-oa6hh7ky	381	20	fusion	fusion	NN
cord-276456-oa6hh7ky	381	21	pore	pore	NN
cord-276456-oa6hh7ky	381	22	dilation	dilation	NN
cord-276456-oa6hh7ky	381	23	Synaptotagmin	Synaptotagmin	NNP
cord-276456-oa6hh7ky	381	24	modulation	modulation	NN
cord-276456-oa6hh7ky	381	25	of	of	IN
cord-276456-oa6hh7ky	381	26	fusion	fusion	NN
cord-276456-oa6hh7ky	381	27	pore	pore	NN
cord-276456-oa6hh7ky	381	28	kinetics	kinetic	NNS
cord-276456-oa6hh7ky	381	29	in	in	IN
cord-276456-oa6hh7ky	381	30	regulated	regulate	VBN
cord-276456-oa6hh7ky	381	31	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	381	32	of	of	IN
cord-276456-oa6hh7ky	381	33	dense	dense	JJ
cord-276456-oa6hh7ky	381	34	-	-	HYPH
cord-276456-oa6hh7ky	381	35	core	core	NN
cord-276456-oa6hh7ky	381	36	vesicles	vesicle	NNS
cord-276456-oa6hh7ky	381	37	Synaptobrevin	Synaptobrevin	NNP
cord-276456-oa6hh7ky	381	38	binding	bind	VBG
cord-276456-oa6hh7ky	381	39	to	to	IN
cord-276456-oa6hh7ky	381	40	synaptophysin	synaptophysin	NNS
cord-276456-oa6hh7ky	381	41	:	:	:
cord-276456-oa6hh7ky	381	42	a	a	DT
cord-276456-oa6hh7ky	381	43	potential	potential	JJ
cord-276456-oa6hh7ky	381	44	mechanism	mechanism	NN
cord-276456-oa6hh7ky	381	45	for	for	IN
cord-276456-oa6hh7ky	381	46	controlling	control	VBG
cord-276456-oa6hh7ky	381	47	the	the	DT
cord-276456-oa6hh7ky	381	48	exocytotic	exocytotic	JJ
cord-276456-oa6hh7ky	381	49	fusion	fusion	NN
cord-276456-oa6hh7ky	381	50	machine	machine	NN
cord-276456-oa6hh7ky	381	51	Vesicle	Vesicle	NNP
cord-276456-oa6hh7ky	381	52	-	-	HYPH
cord-276456-oa6hh7ky	381	53	associated	associate	VBN
cord-276456-oa6hh7ky	381	54	membrane	membrane	NN
cord-276456-oa6hh7ky	381	55	protein	protein	NN
cord-276456-oa6hh7ky	381	56	and	and	CC
cord-276456-oa6hh7ky	381	57	synaptophysin	synaptophysin	NNS
cord-276456-oa6hh7ky	381	58	are	be	VBP
cord-276456-oa6hh7ky	381	59	associated	associate	VBN
cord-276456-oa6hh7ky	381	60	on	on	IN
cord-276456-oa6hh7ky	381	61	the	the	DT
cord-276456-oa6hh7ky	381	62	synaptic	synaptic	JJ
cord-276456-oa6hh7ky	381	63	vesicle	vesicle	NN
cord-276456-oa6hh7ky	381	64	Alpha	Alpha	NNP
cord-276456-oa6hh7ky	381	65	-	-	HYPH
cord-276456-oa6hh7ky	381	66	synuclein	synuclein	NNP
cord-276456-oa6hh7ky	381	67	promotes	promote	VBZ
cord-276456-oa6hh7ky	381	68	SNARE	snare	VB
cord-276456-oa6hh7ky	381	69	-	-	HYPH
cord-276456-oa6hh7ky	381	70	complex	complex	JJ
cord-276456-oa6hh7ky	381	71	assembly	assembly	NN
cord-276456-oa6hh7ky	381	72	in	in	IN
cord-276456-oa6hh7ky	381	73	vivo	vivo	NN
cord-276456-oa6hh7ky	381	74	and	and	CC
cord-276456-oa6hh7ky	382	1	in	in	IN
cord-276456-oa6hh7ky	382	2	vitro	vitro	FW
cord-276456-oa6hh7ky	382	3	Alpha	Alpha	NNP
cord-276456-oa6hh7ky	382	4	-	-	HYPH
cord-276456-oa6hh7ky	382	5	synuclein	synuclein	NNP
cord-276456-oa6hh7ky	382	6	cooperates	cooperate	VBZ
cord-276456-oa6hh7ky	382	7	with	with	IN
cord-276456-oa6hh7ky	382	8	CSPalpha	CSPalpha	NNP
cord-276456-oa6hh7ky	382	9	in	in	IN
cord-276456-oa6hh7ky	382	10	preventing	prevent	VBG
cord-276456-oa6hh7ky	382	11	neurodegeneration	neurodegeneration	NN
cord-276456-oa6hh7ky	383	1	A	a	DT
cord-276456-oa6hh7ky	383	2	single	single	JJ
cord-276456-oa6hh7ky	383	3	-	-	HYPH
cord-276456-oa6hh7ky	383	4	vesicle	vesicle	NN
cord-276456-oa6hh7ky	383	5	content	content	NN
cord-276456-oa6hh7ky	383	6	mixing	mix	VBG
cord-276456-oa6hh7ky	383	7	assay	assay	NN
cord-276456-oa6hh7ky	383	8	for	for	IN
cord-276456-oa6hh7ky	383	9	SNARE	snare	NN
cord-276456-oa6hh7ky	383	10	-	-	HYPH
cord-276456-oa6hh7ky	383	11	mediated	mediate	VBN
cord-276456-oa6hh7ky	383	12	membrane	membrane	NN
cord-276456-oa6hh7ky	383	13	fusion	fusion	NN
cord-276456-oa6hh7ky	383	14	Discrimination	discrimination	NN
cord-276456-oa6hh7ky	383	15	between	between	IN
cord-276456-oa6hh7ky	383	16	docking	docking	NN
cord-276456-oa6hh7ky	383	17	and	and	CC
cord-276456-oa6hh7ky	383	18	fusion	fusion	NN
cord-276456-oa6hh7ky	383	19	of	of	IN
cord-276456-oa6hh7ky	383	20	liposomes	liposome	NNS
cord-276456-oa6hh7ky	383	21	reconstituted	reconstitute	VBN
cord-276456-oa6hh7ky	383	22	with	with	IN
cord-276456-oa6hh7ky	383	23	neuronal	neuronal	JJ
cord-276456-oa6hh7ky	383	24	SNARE	snare	NN
cord-276456-oa6hh7ky	383	25	-	-	HYPH
cord-276456-oa6hh7ky	383	26	proteins	protein	NNS
cord-276456-oa6hh7ky	383	27	using	use	VBG
cord-276456-oa6hh7ky	383	28	FCS	FCS	NNP
cord-276456-oa6hh7ky	383	29	Single	Single	NNP
cord-276456-oa6hh7ky	383	30	-	-	HYPH
cord-276456-oa6hh7ky	383	31	molecule	molecule	NN
cord-276456-oa6hh7ky	383	32	studies	study	NNS
cord-276456-oa6hh7ky	383	33	of	of	IN
cord-276456-oa6hh7ky	383	34	the	the	DT
cord-276456-oa6hh7ky	383	35	neuronal	neuronal	JJ
cord-276456-oa6hh7ky	383	36	SNARE	snare	NN
cord-276456-oa6hh7ky	383	37	fusion	fusion	NN
cord-276456-oa6hh7ky	383	38	machinery	machinery	NN
cord-276456-oa6hh7ky	383	39	Single	single	JJ
cord-276456-oa6hh7ky	383	40	molecule	molecule	NN
cord-276456-oa6hh7ky	383	41	measurements	measurement	NNS
cord-276456-oa6hh7ky	383	42	of	of	IN
cord-276456-oa6hh7ky	383	43	mechanical	mechanical	JJ
cord-276456-oa6hh7ky	383	44	interactions	interaction	NNS
cord-276456-oa6hh7ky	383	45	within	within	IN
cord-276456-oa6hh7ky	383	46	ternary	ternary	JJ
cord-276456-oa6hh7ky	383	47	SNARE	snare	NN
cord-276456-oa6hh7ky	383	48	complexes	complex	NNS
cord-276456-oa6hh7ky	383	49	and	and	CC
cord-276456-oa6hh7ky	383	50	dynamics	dynamic	NNS
cord-276456-oa6hh7ky	383	51	of	of	IN
cord-276456-oa6hh7ky	383	52	their	-PRON-	PRP$
cord-276456-oa6hh7ky	383	53	disassembly	disassembly	NN
cord-276456-oa6hh7ky	383	54	:	:	:
cord-276456-oa6hh7ky	383	55	SNAP25	SNAP25	NNP
cord-276456-oa6hh7ky	383	56	vs.	vs.	FW
cord-276456-oa6hh7ky	383	57	SNAP23	snap23	XX
cord-276456-oa6hh7ky	384	1	Single	single	JJ
cord-276456-oa6hh7ky	384	2	molecule	molecule	NN
cord-276456-oa6hh7ky	384	3	mechanical	mechanical	JJ
cord-276456-oa6hh7ky	384	4	probing	probing	NN
cord-276456-oa6hh7ky	384	5	of	of	IN
cord-276456-oa6hh7ky	384	6	the	the	DT
cord-276456-oa6hh7ky	384	7	SNARE	snare	NN
cord-276456-oa6hh7ky	384	8	protein	protein	NN
cord-276456-oa6hh7ky	384	9	interactions	interaction	NNS
cord-276456-oa6hh7ky	384	10	Single	single	JJ
cord-276456-oa6hh7ky	384	11	molecule	molecule	NN
cord-276456-oa6hh7ky	384	12	observation	observation	NN
cord-276456-oa6hh7ky	384	13	of	of	IN
cord-276456-oa6hh7ky	384	14	liposome	liposome	NN
cord-276456-oa6hh7ky	384	15	-	-	HYPH
cord-276456-oa6hh7ky	384	16	bilayer	bilayer	NN
cord-276456-oa6hh7ky	384	17	fusion	fusion	NN
cord-276456-oa6hh7ky	384	18	thermally	thermally	RB
cord-276456-oa6hh7ky	384	19	induced	induce	VBN
cord-276456-oa6hh7ky	384	20	by	by	IN
cord-276456-oa6hh7ky	384	21	soluble	soluble	JJ
cord-276456-oa6hh7ky	384	22	N	n	CD
cord-276456-oa6hh7ky	384	23	-	-	HYPH
cord-276456-oa6hh7ky	384	24	ethyl	ethyl	NN
cord-276456-oa6hh7ky	384	25	maleimide	maleimide	NN
cord-276456-oa6hh7ky	384	26	sensitive	sensitive	JJ
cord-276456-oa6hh7ky	384	27	-	-	HYPH
cord-276456-oa6hh7ky	384	28	factor	factor	NN
cord-276456-oa6hh7ky	384	29	attachment	attachment	NN
cord-276456-oa6hh7ky	384	30	protein	protein	NN
cord-276456-oa6hh7ky	384	31	receptors	receptor	NNS
cord-276456-oa6hh7ky	384	32	(	(	-LRB-
cord-276456-oa6hh7ky	384	33	SNAREs	SNAREs	NNP
cord-276456-oa6hh7ky	384	34	)	)	-RRB-
cord-276456-oa6hh7ky	385	1	Visualizing	visualize	VBG
cord-276456-oa6hh7ky	385	2	infection	infection	NN
cord-276456-oa6hh7ky	385	3	of	of	IN
cord-276456-oa6hh7ky	385	4	individual	individual	JJ
cord-276456-oa6hh7ky	385	5	influenza	influenza	NN
cord-276456-oa6hh7ky	385	6	viruses	viruse	VBZ
cord-276456-oa6hh7ky	385	7	Single	single	JJ
cord-276456-oa6hh7ky	385	8	-	-	HYPH
cord-276456-oa6hh7ky	385	9	particle	particle	NN
cord-276456-oa6hh7ky	385	10	kinetics	kinetic	NNS
cord-276456-oa6hh7ky	385	11	of	of	IN
cord-276456-oa6hh7ky	385	12	influenza	influenza	NN
cord-276456-oa6hh7ky	385	13	virus	virus	NN
cord-276456-oa6hh7ky	385	14	membrane	membrane	NN
cord-276456-oa6hh7ky	385	15	fusion	fusion	NN
cord-276456-oa6hh7ky	386	1	GTPase	GTPase	NNP
cord-276456-oa6hh7ky	386	2	cycle	cycle	NN
cord-276456-oa6hh7ky	386	3	of	of	IN
cord-276456-oa6hh7ky	386	4	dynamin	dynamin	NN
cord-276456-oa6hh7ky	386	5	is	be	VBZ
cord-276456-oa6hh7ky	386	6	coupled	couple	VBN
cord-276456-oa6hh7ky	386	7	to	to	IN
cord-276456-oa6hh7ky	386	8	membrane	membrane	NN
cord-276456-oa6hh7ky	386	9	squeeze	squeeze	NN
cord-276456-oa6hh7ky	386	10	and	and	CC
cord-276456-oa6hh7ky	386	11	release	release	NN
cord-276456-oa6hh7ky	386	12	,	,	,
cord-276456-oa6hh7ky	386	13	leading	lead	VBG
cord-276456-oa6hh7ky	386	14	to	to	IN
cord-276456-oa6hh7ky	386	15	spontaneous	spontaneous	JJ
cord-276456-oa6hh7ky	386	16	fission	fission	NN
cord-276456-oa6hh7ky	386	17	Real	real	JJ
cord-276456-oa6hh7ky	386	18	-	-	HYPH
cord-276456-oa6hh7ky	386	19	time	time	NN
cord-276456-oa6hh7ky	386	20	visualization	visualization	NN
cord-276456-oa6hh7ky	386	21	of	of	IN
cord-276456-oa6hh7ky	386	22	dynamin	dynamin	NN
cord-276456-oa6hh7ky	386	23	-	-	HYPH
cord-276456-oa6hh7ky	386	24	catalyzed	catalyze	VBN
cord-276456-oa6hh7ky	386	25	membrane	membrane	NN
cord-276456-oa6hh7ky	386	26	fission	fission	NN
cord-276456-oa6hh7ky	386	27	and	and	CC
cord-276456-oa6hh7ky	386	28	vesicle	vesicle	NN
cord-276456-oa6hh7ky	386	29	release	release	NN
cord-276456-oa6hh7ky	386	30	Membrane	Membrane	NNP
cord-276456-oa6hh7ky	386	31	fission	fission	NN
cord-276456-oa6hh7ky	386	32	:	:	:
cord-276456-oa6hh7ky	386	33	model	model	NN
cord-276456-oa6hh7ky	386	34	for	for	IN
cord-276456-oa6hh7ky	386	35	intermediate	intermediate	JJ
cord-276456-oa6hh7ky	386	36	structures	structure	NNS
cord-276456-oa6hh7ky	387	1	Dynamin	Dynamin	NNP
cord-276456-oa6hh7ky	387	2	self	self	NN
cord-276456-oa6hh7ky	387	3	-	-	HYPH
cord-276456-oa6hh7ky	387	4	assembly	assembly	NN
cord-276456-oa6hh7ky	387	5	stimulates	stimulate	VBZ
cord-276456-oa6hh7ky	387	6	its	-PRON-	PRP$
cord-276456-oa6hh7ky	387	7	GTPase	GTPase	NNP
cord-276456-oa6hh7ky	387	8	activity	activity	NN
cord-276456-oa6hh7ky	387	9	Real	real	JJ
cord-276456-oa6hh7ky	387	10	-	-	HYPH
cord-276456-oa6hh7ky	387	11	time	time	NN
cord-276456-oa6hh7ky	387	12	detection	detection	NN
cord-276456-oa6hh7ky	387	13	reveals	reveal	VBZ
cord-276456-oa6hh7ky	387	14	that	that	IN
cord-276456-oa6hh7ky	387	15	effectors	effector	NNS
cord-276456-oa6hh7ky	387	16	couple	couple	NN
cord-276456-oa6hh7ky	387	17	dynamin	dynamin	NNP
cord-276456-oa6hh7ky	387	18	's	's	POS
cord-276456-oa6hh7ky	387	19	GTP	gtp	NN
cord-276456-oa6hh7ky	387	20	-	-	HYPH
cord-276456-oa6hh7ky	387	21	dependent	dependent	JJ
cord-276456-oa6hh7ky	387	22	conformational	conformational	JJ
cord-276456-oa6hh7ky	387	23	changes	change	NNS
cord-276456-oa6hh7ky	387	24	to	to	IN
cord-276456-oa6hh7ky	387	25	the	the	DT
cord-276456-oa6hh7ky	387	26	membrane	membrane	NN
cord-276456-oa6hh7ky	387	27	A	a	DT
cord-276456-oa6hh7ky	387	28	new	new	JJ
cord-276456-oa6hh7ky	387	29	role	role	NN
cord-276456-oa6hh7ky	387	30	for	for	IN
cord-276456-oa6hh7ky	387	31	the	the	DT
cord-276456-oa6hh7ky	387	32	dynamin	dynamin	NN
cord-276456-oa6hh7ky	387	33	GTPase	GTPase	NNP
cord-276456-oa6hh7ky	387	34	in	in	IN
cord-276456-oa6hh7ky	387	35	the	the	DT
cord-276456-oa6hh7ky	387	36	regulation	regulation	NN
cord-276456-oa6hh7ky	387	37	of	of	IN
cord-276456-oa6hh7ky	387	38	fusion	fusion	NN
cord-276456-oa6hh7ky	387	39	pore	pore	NN
cord-276456-oa6hh7ky	387	40	expansion	expansion	NN
cord-276456-oa6hh7ky	388	1	Localized	localized	JJ
cord-276456-oa6hh7ky	388	2	topological	topological	JJ
cord-276456-oa6hh7ky	388	3	changes	change	NNS
cord-276456-oa6hh7ky	388	4	of	of	IN
cord-276456-oa6hh7ky	388	5	the	the	DT
cord-276456-oa6hh7ky	388	6	plasma	plasma	NN
cord-276456-oa6hh7ky	388	7	membrane	membrane	NN
cord-276456-oa6hh7ky	388	8	upon	upon	IN
cord-276456-oa6hh7ky	388	9	exocytosis	exocytosis	NN
cord-276456-oa6hh7ky	388	10	visualized	visualize	VBN
cord-276456-oa6hh7ky	388	11	by	by	IN
cord-276456-oa6hh7ky	388	12	polarized	polarized	JJ
cord-276456-oa6hh7ky	388	13	TIRFM	TIRFM	NNP
cord-276456-oa6hh7ky	388	14	This	this	DT
cord-276456-oa6hh7ky	388	15	work	work	NN
cord-276456-oa6hh7ky	388	16	was	be	VBD
cord-276456-oa6hh7ky	388	17	supported	support	VBN
cord-276456-oa6hh7ky	388	18	by	by	IN
cord-276456-oa6hh7ky	388	19	NIH	NIH	NNP
cord-276456-oa6hh7ky	388	20	Grant	Grant	NNP
cord-276456-oa6hh7ky	388	21	no	no	NN
cord-276456-oa6hh7ky	388	22	.	.	.
cord-276456-oa6hh7ky	389	1	5R01GM069596	5R01GM069596	NNP
cord-276456-oa6hh7ky	389	2	to	to	IN
cord-276456-oa6hh7ky	389	3	R.	R.	NNP
cord-276456-oa6hh7ky	389	4	Collins	Collins	NNP
cord-276456-oa6hh7ky	389	5	,	,	,
cord-276456-oa6hh7ky	389	6	R56-NS38129	R56-NS38129	NNP
cord-276456-oa6hh7ky	389	7	to	to	IN
cord-276456-oa6hh7ky	389	8	RWH	RWH	NNP
cord-276456-oa6hh7ky	389	9	,	,	,
cord-276456-oa6hh7ky	389	10	and	and	CC
cord-276456-oa6hh7ky	389	11	the	the	DT
cord-276456-oa6hh7ky	389	12	Intramural	Intramural	NNP
cord-276456-oa6hh7ky	389	13	Program	Program	NNP
cord-276456-oa6hh7ky	389	14	of	of	IN
cord-276456-oa6hh7ky	389	15	the	the	DT
cord-276456-oa6hh7ky	389	16	NICHD	NICHD	NNP
cord-276456-oa6hh7ky	389	17	,	,	,
cord-276456-oa6hh7ky	389	18	NIH	NIH	NNP
cord-276456-oa6hh7ky	389	19	.	.	.
cord-276456-oa6hh7ky	390	1	Many	many	JJ
cord-276456-oa6hh7ky	390	2	thanks	thank	NNS
cord-276456-oa6hh7ky	390	3	to	to	IN
cord-276456-oa6hh7ky	390	4	Fabio	Fabio	NNP
cord-276456-oa6hh7ky	390	5	Rinaldi	Rinaldi	NNP
cord-276456-oa6hh7ky	390	6	for	for	IN
cord-276456-oa6hh7ky	390	7	help	help	NN
cord-276456-oa6hh7ky	390	8	with	with	IN
cord-276456-oa6hh7ky	390	9	figure	figure	NN
cord-276456-oa6hh7ky	390	10	preparation	preparation	NN
cord-276456-oa6hh7ky	390	11	,	,	,
cord-276456-oa6hh7ky	390	12	Fred	Fred	NNP
cord-276456-oa6hh7ky	390	13	Cohen	Cohen	NNP
cord-276456-oa6hh7ky	390	14	for	for	IN
cord-276456-oa6hh7ky	390	15	his	-PRON-	PRP$
cord-276456-oa6hh7ky	390	16	discussion	discussion	NN
cord-276456-oa6hh7ky	390	17	of	of	IN
cord-276456-oa6hh7ky	390	18	the	the	DT
cord-276456-oa6hh7ky	390	19	viral	viral	JJ
cord-276456-oa6hh7ky	390	20	helical	helical	JJ
cord-276456-oa6hh7ky	390	21	bundle	bundle	NN
cord-276456-oa6hh7ky	390	22	timing	timing	NN
cord-276456-oa6hh7ky	390	23	experiments	experiment	NNS
cord-276456-oa6hh7ky	390	24	,	,	,
cord-276456-oa6hh7ky	390	25	and	and	CC
cord-276456-oa6hh7ky	390	26	Gary	Gary	NNP
cord-276456-oa6hh7ky	390	27	Whittaker	Whittaker	NNP
cord-276456-oa6hh7ky	390	28	for	for	IN
cord-276456-oa6hh7ky	390	29	helpful	helpful	JJ
cord-276456-oa6hh7ky	390	30	discussions	discussion	NNS
cord-276456-oa6hh7ky	390	31	.	.	.