id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003144-nqkw5v3w	Qu, Zehui	Label‐Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain	2017-11-24		.txt	text/plain	5514	319	51	title: Label‐Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain Significant differences exist between the highly pathogenic (HP) porcine reproductive and respiratory syndrome virus (PRRSV) and its attenuated pathogenic (AP) strain in the ability to infect host cells. This is the first attempt to explore the differential characteristics between HP‐PRRSV and its attenuated PRRSV infected PAMs focusing on membrane proteins which will be of great help to further understand the different infective mechanisms of HP‐PRRSV and AP‐PRRSV. Differentially expressed proteins between control and HP-PRRSV-infected cells (Con/HP) and the www.advancedsciencenews.com www.proteomics-journal.com p <0.01 and ratio >2 or <0.5 indicated quantitative difference between two groups. By analyzing detected proteins in HP-infected, AP-PRRSV-infected, and control group, proteins related to the immune response or virus replication were identified that may elucidate unique pathways used by different virulent PRRSVs for cell entry, virus replication, and immune escape mechanisms.	./cache/cord-003144-nqkw5v3w.txt	./txt/cord-003144-nqkw5v3w.txt