id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010094-t0y3t9v3	Tong, Ting	Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms	2020-02-20		.txt	text/plain	6486	344	51	[32, [36] [37] [38] [39] [40] [41] [43] [44] [45] [46] [47] In this study, a kind of highly biocompatible Gly-CDs was synthesized from active ingredient of Chinese herbal medicine, which combines the high biocompatibility of CDs with the excellent antiviral properties of glycyrrhizic acid and inhibit the proliferation of PRRSV by ≈5 orders of magnitude. According to the experimental design (Scheme S1, Supporting Information), the addition of Gly-CDs significantly reduced PRRSV titers in intracellular and cell supernatants at 12, 24, 36, and 48 h post infection (hpi), with a maximal reduction of ≈10 5 -fold by plaque assay (Figure 3a,b) , demonstrating the strong antiviral effect of Gly-CDs on PRRSV. Adsorption Assay: MARC-145 cells were precooled at 4 °C for 30 min, followed by infection with PRRSV (MOI = 0.001) for 2 h at 4 °C in the presence of 0.30 mg mL −1 Gly-CDs in DMEM (containing 2% FBS).	./cache/cord-010094-t0y3t9v3.txt	./txt/cord-010094-t0y3t9v3.txt