id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282242-5tkhjiwl	Gómez-Laguna, J.	Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus	2009-08-19		.txt	text/plain	3816	206	49	title: Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus The aim of the present study was to characterize the production of cytokines by subpopulations of pulmonary macrophages in pigs infected by the PRRS virus (PRRSV). Several studies have examined the role of cytokines in the pathogenesis of PRRS (Van Reeth and Nauwynck, 2000) ; however, it is not clear how cytokines participate in macrophage activation during PRRSV infection or how they regulate development of the immune response to the virus. The expression of IFN-g by macrophages and lymphocytes has been previously reported in the lung of PRRSV-infected pigs (Thanawongnuwech et al., 2003) . Therefore, the expression of IL-10 observed in the present study might be responsible for reduced expression of cytokines such as IFN-a, IFN-g, IL-12p40 and TNF-a, that in turn may impair prolonged viral replication in the lung of infected animals.	./cache/cord-282242-5tkhjiwl.txt	./txt/cord-282242-5tkhjiwl.txt