id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299038-e0nsol3y	Chang, Yung-Chi	Siglecs at the Host–Pathogen Interface	2020-03-10		.txt	text/plain	6878	314	34	Conversely, Siglec-1 is a macrophage phagocytic receptor that engages GBS and other sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response, whereas certain viruses and parasites use Siglec-1 to gain entry to immune cells as a proximal step in the infectious process. The interplay between a particular sialylated human pathogen, group B Streptococcus (GBS), and host immune responses serves as a good first example to illustrate the role of Siglecs and bacterial expression of Sia in the pathogenesis of infection. Importantly, in addition to Sia-dependent Siglec engagement, certain GBS strains can use the surface-anchored β protein to bind human Siglec-5, another inhibitory Siglec preferentially expressed on macrophages and neutrophils. Loss of Siglec-1 expression not only affected the macrophage sampling and trapping capabilities but also the production of anti-GBS antibodies, suggesting a key role in optimization of antigen presentation and subsequent adaptive immune response against sialylated pathogens (Chang et al.	./cache/cord-299038-e0nsol3y.txt	./txt/cord-299038-e0nsol3y.txt