id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342276-zrsnahi7	Sun, Ying	Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells	2011-12-16		.txt	text/plain	3886	195	44	title: Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells In this study, the role of the plasma membrane cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection of MARC-145 cells was investigated. Previous studies demonstrated that plasma membrane cholesterol plays an important role in the entry and infection processes of many viruses, especially in some enveloped viruses [21] , including Human immunodeficiency virus type 1 (HIV-1) [22] , Poliovirus [23] , Murine coronavirus [24] , Vaccinia virus [25] , Herpes simplex virus [26] , Foot-and-mouth disease virus [27] , and Severe acute respiratory syndrome-related coronavirus (SARS-CoV) [28] . Altogether, these data indicated that cellular membrane cholesterol was required for PRRSV entry into MARC-145 cells, and its depletion by MβCD mainly affects virus attachment, rather than penetration.	./cache/cord-342276-zrsnahi7.txt	./txt/cord-342276-zrsnahi7.txt