id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351881-qea4b0i5	Eck, Melanie	Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs	2016-02-19		.txt	text/plain	6275	329	48	title: Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs However, none of the PRRSV antigens expressed from VRP, with the exception of the N protein, did induce any detectable antibody response in pigs before challenge infection with PRRSV. These data show that the VSV replicon vector can induce immune responses to heterologous proteins in pigs, but that the PRRSV envelope proteins expressed from VSV VRP are poorly immunogenic. Again, before challenge infection, vaccination with VRP expressing the structural proteins of PRRSV did not induce any detectable antibody response against GP5, GP4 and GP3 as measured by ELISA (not shown). Following challenge infection, GP5-specific antibody responses were detected on day 7 pi in 2 out of 4 pigs, and all pigs vaccinated with VRP expressing the PRRSV proteins seroconverted to GP5 at day 11 pi (Table 3 ).	./cache/cord-351881-qea4b0i5.txt	./txt/cord-351881-qea4b0i5.txt