id	sid	tid	token	lemma	pos
cord-258536-qnn9hp8e	1	1	key	key	JJ
cord-258536-qnn9hp8e	1	2	:	:	:
cord-258536-qnn9hp8e	1	3	cord-258536-qnn9hp8e	cord-258536-qnn9hp8e	NN
cord-258536-qnn9hp8e	1	4	authors	author	NNS
cord-258536-qnn9hp8e	1	5	:	:	:
cord-258536-qnn9hp8e	1	6	Cong	Cong	NNP
cord-258536-qnn9hp8e	1	7	,	,	,
cord-258536-qnn9hp8e	1	8	Yingying	Yingying	NNP
cord-258536-qnn9hp8e	1	9	;	;	:
cord-258536-qnn9hp8e	1	10	Verlhac	Verlhac	NNP
cord-258536-qnn9hp8e	1	11	,	,	,
cord-258536-qnn9hp8e	1	12	Pauline	Pauline	NNP
cord-258536-qnn9hp8e	1	13	;	;	:
cord-258536-qnn9hp8e	1	14	Reggiori	Reggiori	NNP
cord-258536-qnn9hp8e	1	15	,	,	,
cord-258536-qnn9hp8e	1	16	Fulvio	Fulvio	NNP
cord-258536-qnn9hp8e	1	17	title	title	NN
cord-258536-qnn9hp8e	1	18	:	:	:
cord-258536-qnn9hp8e	1	19	The	the	DT
cord-258536-qnn9hp8e	1	20	Interaction	Interaction	NNP
cord-258536-qnn9hp8e	1	21	between	between	IN
cord-258536-qnn9hp8e	1	22	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	1	23	and	and	CC
cord-258536-qnn9hp8e	1	24	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	1	25	Components	Components	NNP
cord-258536-qnn9hp8e	1	26	date	date	NN
cord-258536-qnn9hp8e	1	27	:	:	:
cord-258536-qnn9hp8e	1	28	2017	2017	CD
cord-258536-qnn9hp8e	1	29	-	-	HYPH
cord-258536-qnn9hp8e	1	30	07	07	CD
cord-258536-qnn9hp8e	1	31	-	-	HYPH
cord-258536-qnn9hp8e	1	32	11	11	CD
cord-258536-qnn9hp8e	1	33	journal	journal	NN
cord-258536-qnn9hp8e	1	34	:	:	:
cord-258536-qnn9hp8e	2	1	Viruses	virus	NNS
cord-258536-qnn9hp8e	2	2	DOI	DOI	NNP
cord-258536-qnn9hp8e	2	3	:	:	:
cord-258536-qnn9hp8e	3	1	10.3390	10.3390	CD
cord-258536-qnn9hp8e	4	1	/v9070182	/v9070182	NFP
cord-258536-qnn9hp8e	4	2	sha	sha	NNP
cord-258536-qnn9hp8e	4	3	:	:	:
cord-258536-qnn9hp8e	5	1	0d82c429737f250a7bcd230fea2e4725edc2439a	0d82c429737f250a7bcd230fea2e4725edc2439a	LS
cord-258536-qnn9hp8e	6	1	doc_id	doc_id	CD
cord-258536-qnn9hp8e	7	1	:	:	:
cord-258536-qnn9hp8e	7	2	258536	258536	CD
cord-258536-qnn9hp8e	7	3	cord_uid	cord_uid	NNS
cord-258536-qnn9hp8e	7	4	:	:	:
cord-258536-qnn9hp8e	8	1	qnn9hp8e	qnn9hp8e	NNP
cord-258536-qnn9hp8e	8	2	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	8	3	is	be	VBZ
cord-258536-qnn9hp8e	8	4	a	a	DT
cord-258536-qnn9hp8e	8	5	conserved	conserved	JJ
cord-258536-qnn9hp8e	8	6	intracellular	intracellular	JJ
cord-258536-qnn9hp8e	8	7	catabolic	catabolic	JJ
cord-258536-qnn9hp8e	8	8	pathway	pathway	NN
cord-258536-qnn9hp8e	8	9	that	that	WDT
cord-258536-qnn9hp8e	8	10	allows	allow	VBZ
cord-258536-qnn9hp8e	8	11	cells	cell	NNS
cord-258536-qnn9hp8e	8	12	to	to	TO
cord-258536-qnn9hp8e	8	13	maintain	maintain	VB
cord-258536-qnn9hp8e	8	14	homeostasis	homeostasis	NN
cord-258536-qnn9hp8e	8	15	through	through	IN
cord-258536-qnn9hp8e	8	16	the	the	DT
cord-258536-qnn9hp8e	8	17	degradation	degradation	NN
cord-258536-qnn9hp8e	8	18	of	of	IN
cord-258536-qnn9hp8e	8	19	deleterious	deleterious	JJ
cord-258536-qnn9hp8e	8	20	components	component	NNS
cord-258536-qnn9hp8e	8	21	via	via	IN
cord-258536-qnn9hp8e	8	22	specialized	specialized	JJ
cord-258536-qnn9hp8e	8	23	double	double	JJ
cord-258536-qnn9hp8e	8	24	-	-	HYPH
cord-258536-qnn9hp8e	8	25	membrane	membrane	NN
cord-258536-qnn9hp8e	8	26	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	8	27	called	call	VBN
cord-258536-qnn9hp8e	8	28	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	8	29	.	.	.
cord-258536-qnn9hp8e	9	1	During	during	IN
cord-258536-qnn9hp8e	9	2	the	the	DT
cord-258536-qnn9hp8e	9	3	past	past	JJ
cord-258536-qnn9hp8e	9	4	decades	decade	NNS
cord-258536-qnn9hp8e	9	5	,	,	,
cord-258536-qnn9hp8e	9	6	it	-PRON-	PRP
cord-258536-qnn9hp8e	9	7	has	have	VBZ
cord-258536-qnn9hp8e	9	8	been	be	VBN
cord-258536-qnn9hp8e	9	9	revealed	reveal	VBN
cord-258536-qnn9hp8e	9	10	that	that	IN
cord-258536-qnn9hp8e	9	11	numerous	numerous	JJ
cord-258536-qnn9hp8e	9	12	pathogens	pathogen	NNS
cord-258536-qnn9hp8e	9	13	,	,	,
cord-258536-qnn9hp8e	9	14	including	include	VBG
cord-258536-qnn9hp8e	9	15	viruses	virus	NNS
cord-258536-qnn9hp8e	9	16	,	,	,
cord-258536-qnn9hp8e	9	17	usurp	usurp	VB
cord-258536-qnn9hp8e	9	18	autophagy	autophagy	NN
cord-258536-qnn9hp8e	9	19	in	in	IN
cord-258536-qnn9hp8e	9	20	order	order	NN
cord-258536-qnn9hp8e	9	21	to	to	TO
cord-258536-qnn9hp8e	9	22	promote	promote	VB
cord-258536-qnn9hp8e	9	23	their	-PRON-	PRP$
cord-258536-qnn9hp8e	9	24	propagation	propagation	NN
cord-258536-qnn9hp8e	9	25	.	.	.
cord-258536-qnn9hp8e	10	1	Nidovirales	nidovirale	NNS
cord-258536-qnn9hp8e	10	2	are	be	VBP
cord-258536-qnn9hp8e	10	3	an	an	DT
cord-258536-qnn9hp8e	10	4	order	order	NN
cord-258536-qnn9hp8e	10	5	of	of	IN
cord-258536-qnn9hp8e	10	6	enveloped	envelop	VBN
cord-258536-qnn9hp8e	10	7	viruses	virus	NNS
cord-258536-qnn9hp8e	10	8	with	with	IN
cord-258536-qnn9hp8e	10	9	large	large	JJ
cord-258536-qnn9hp8e	10	10	single	single	JJ
cord-258536-qnn9hp8e	10	11	-	-	HYPH
cord-258536-qnn9hp8e	10	12	stranded	strand	VBN
cord-258536-qnn9hp8e	10	13	positive	positive	JJ
cord-258536-qnn9hp8e	10	14	RNA	RNA	NNP
cord-258536-qnn9hp8e	10	15	genomes	genome	NNS
cord-258536-qnn9hp8e	10	16	.	.	.
cord-258536-qnn9hp8e	11	1	Four	four	CD
cord-258536-qnn9hp8e	11	2	virus	virus	NN
cord-258536-qnn9hp8e	11	3	families	family	NNS
cord-258536-qnn9hp8e	11	4	(	(	-LRB-
cord-258536-qnn9hp8e	11	5	Arterividae	Arterividae	NNP
cord-258536-qnn9hp8e	11	6	,	,	,
cord-258536-qnn9hp8e	11	7	Coronaviridae	Coronaviridae	NNP
cord-258536-qnn9hp8e	11	8	,	,	,
cord-258536-qnn9hp8e	11	9	Mesoniviridae	Mesoniviridae	NNP
cord-258536-qnn9hp8e	11	10	,	,	,
cord-258536-qnn9hp8e	11	11	and	and	CC
cord-258536-qnn9hp8e	11	12	Roniviridae	Roniviridae	NNP
cord-258536-qnn9hp8e	11	13	)	)	-RRB-
cord-258536-qnn9hp8e	11	14	are	be	VBP
cord-258536-qnn9hp8e	11	15	part	part	NN
cord-258536-qnn9hp8e	11	16	of	of	IN
cord-258536-qnn9hp8e	11	17	this	this	DT
cord-258536-qnn9hp8e	11	18	order	order	NN
cord-258536-qnn9hp8e	11	19	,	,	,
cord-258536-qnn9hp8e	11	20	which	which	WDT
cord-258536-qnn9hp8e	11	21	comprises	comprise	VBZ
cord-258536-qnn9hp8e	11	22	several	several	JJ
cord-258536-qnn9hp8e	11	23	human	human	NN
cord-258536-qnn9hp8e	11	24	and	and	CC
cord-258536-qnn9hp8e	11	25	animal	animal	NN
cord-258536-qnn9hp8e	11	26	pathogens	pathogen	NNS
cord-258536-qnn9hp8e	11	27	of	of	IN
cord-258536-qnn9hp8e	11	28	medical	medical	JJ
cord-258536-qnn9hp8e	11	29	and	and	CC
cord-258536-qnn9hp8e	11	30	veterinary	veterinary	JJ
cord-258536-qnn9hp8e	11	31	importance	importance	NN
cord-258536-qnn9hp8e	11	32	.	.	.
cord-258536-qnn9hp8e	12	1	In	in	IN
cord-258536-qnn9hp8e	12	2	host	host	NN
cord-258536-qnn9hp8e	12	3	cells	cell	NNS
cord-258536-qnn9hp8e	12	4	,	,	,
cord-258536-qnn9hp8e	12	5	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	12	6	induce	induce	VBP
cord-258536-qnn9hp8e	12	7	membrane	membrane	NN
cord-258536-qnn9hp8e	12	8	rearrangements	rearrangement	NNS
cord-258536-qnn9hp8e	12	9	including	include	VBG
cord-258536-qnn9hp8e	12	10	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	12	11	formation	formation	NN
cord-258536-qnn9hp8e	12	12	.	.	.
cord-258536-qnn9hp8e	13	1	The	the	DT
cord-258536-qnn9hp8e	13	2	relevance	relevance	NN
cord-258536-qnn9hp8e	13	3	and	and	CC
cord-258536-qnn9hp8e	13	4	putative	putative	JJ
cord-258536-qnn9hp8e	13	5	mechanism	mechanism	NN
cord-258536-qnn9hp8e	13	6	of	of	IN
cord-258536-qnn9hp8e	13	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	13	8	usurpation	usurpation	NN
cord-258536-qnn9hp8e	13	9	,	,	,
cord-258536-qnn9hp8e	13	10	however	however	RB
cord-258536-qnn9hp8e	13	11	,	,	,
cord-258536-qnn9hp8e	13	12	remain	remain	VBP
cord-258536-qnn9hp8e	13	13	largely	largely	RB
cord-258536-qnn9hp8e	13	14	elusive	elusive	JJ
cord-258536-qnn9hp8e	13	15	.	.	.
cord-258536-qnn9hp8e	14	1	Here	here	RB
cord-258536-qnn9hp8e	14	2	,	,	,
cord-258536-qnn9hp8e	14	3	we	-PRON-	PRP
cord-258536-qnn9hp8e	14	4	review	review	VBP
cord-258536-qnn9hp8e	14	5	the	the	DT
cord-258536-qnn9hp8e	14	6	current	current	JJ
cord-258536-qnn9hp8e	14	7	knowledge	knowledge	NN
cord-258536-qnn9hp8e	14	8	about	about	IN
cord-258536-qnn9hp8e	14	9	the	the	DT
cord-258536-qnn9hp8e	14	10	possible	possible	JJ
cord-258536-qnn9hp8e	14	11	interplay	interplay	NN
cord-258536-qnn9hp8e	14	12	between	between	IN
cord-258536-qnn9hp8e	14	13	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	14	14	and	and	CC
cord-258536-qnn9hp8e	14	15	autophagy	autophagy	NN
cord-258536-qnn9hp8e	14	16	.	.	.
cord-258536-qnn9hp8e	15	1	Nidoviruses	Nidoviruses	NNP
cord-258536-qnn9hp8e	15	2	rank	rank	NN
cord-258536-qnn9hp8e	15	3	among	among	IN
cord-258536-qnn9hp8e	15	4	the	the	DT
cord-258536-qnn9hp8e	15	5	most	most	RBS
cord-258536-qnn9hp8e	15	6	complex	complex	JJ
cord-258536-qnn9hp8e	15	7	RNA	RNA	NNP
cord-258536-qnn9hp8e	15	8	viruses	virus	NNS
cord-258536-qnn9hp8e	15	9	and	and	CC
cord-258536-qnn9hp8e	15	10	their	-PRON-	PRP$
cord-258536-qnn9hp8e	15	11	molecular	molecular	JJ
cord-258536-qnn9hp8e	15	12	genetics	genetic	NNS
cord-258536-qnn9hp8e	15	13	clearly	clearly	RB
cord-258536-qnn9hp8e	15	14	discriminates	discriminate	VBZ
cord-258536-qnn9hp8e	15	15	them	-PRON-	PRP
cord-258536-qnn9hp8e	15	16	from	from	IN
cord-258536-qnn9hp8e	15	17	other	other	JJ
cord-258536-qnn9hp8e	15	18	RNA	RNA	NNP
cord-258536-qnn9hp8e	15	19	virus	virus	NN
cord-258536-qnn9hp8e	15	20	orders	order	NNS
cord-258536-qnn9hp8e	15	21	[	[	-LRB-
cord-258536-qnn9hp8e	15	22	1	1	CD
cord-258536-qnn9hp8e	15	23	]	]	-RRB-
cord-258536-qnn9hp8e	15	24	.	.	.
cord-258536-qnn9hp8e	16	1	Still	still	RB
cord-258536-qnn9hp8e	16	2	,	,	,
cord-258536-qnn9hp8e	16	3	our	-PRON-	PRP$
cord-258536-qnn9hp8e	16	4	knowledge	knowledge	NN
cord-258536-qnn9hp8e	16	5	about	about	IN
cord-258536-qnn9hp8e	16	6	their	-PRON-	PRP$
cord-258536-qnn9hp8e	16	7	life	life	NN
cord-258536-qnn9hp8e	16	8	cycle	cycle	NN
cord-258536-qnn9hp8e	16	9	,	,	,
cord-258536-qnn9hp8e	16	10	mostly	mostly	RB
cord-258536-qnn9hp8e	16	11	unveiled	unveil	VBN
cord-258536-qnn9hp8e	16	12	with	with	IN
cord-258536-qnn9hp8e	16	13	studies	study	NNS
cord-258536-qnn9hp8e	16	14	on	on	IN
cord-258536-qnn9hp8e	16	15	Coronaviruses	Coronaviruses	NNP
cord-258536-qnn9hp8e	16	16	(	(	-LRB-
cord-258536-qnn9hp8e	16	17	CoVs	CoVs	NNP
cord-258536-qnn9hp8e	16	18	)	)	-RRB-
cord-258536-qnn9hp8e	16	19	,	,	,
cord-258536-qnn9hp8e	16	20	is	be	VBZ
cord-258536-qnn9hp8e	16	21	very	very	RB
cord-258536-qnn9hp8e	16	22	limited	limited	JJ
cord-258536-qnn9hp8e	16	23	[	[	-LRB-
cord-258536-qnn9hp8e	16	24	1	1	CD
cord-258536-qnn9hp8e	16	25	,	,	,
cord-258536-qnn9hp8e	16	26	3	3	CD
cord-258536-qnn9hp8e	16	27	,	,	,
cord-258536-qnn9hp8e	16	28	17	17	CD
cord-258536-qnn9hp8e	16	29	,	,	,
cord-258536-qnn9hp8e	16	30	18	18	CD
cord-258536-qnn9hp8e	16	31	]	]	-RRB-
cord-258536-qnn9hp8e	16	32	.	.	.
cord-258536-qnn9hp8e	17	1	To	to	TO
cord-258536-qnn9hp8e	17	2	enter	enter	VB
cord-258536-qnn9hp8e	17	3	cells	cell	NNS
cord-258536-qnn9hp8e	17	4	,	,	,
cord-258536-qnn9hp8e	17	5	Nidoviruses	Nidoviruses	NNPS
cord-258536-qnn9hp8e	17	6	bind	bind	VBP
cord-258536-qnn9hp8e	17	7	to	to	IN
cord-258536-qnn9hp8e	17	8	cell	cell	NN
cord-258536-qnn9hp8e	17	9	surface	surface	NN
cord-258536-qnn9hp8e	17	10	receptors	receptor	NNS
cord-258536-qnn9hp8e	17	11	,	,	,
cord-258536-qnn9hp8e	17	12	an	an	DT
cord-258536-qnn9hp8e	17	13	event	event	NN
cord-258536-qnn9hp8e	17	14	that	that	WDT
cord-258536-qnn9hp8e	17	15	precedes	precede	VBZ
cord-258536-qnn9hp8e	17	16	the	the	DT
cord-258536-qnn9hp8e	17	17	fusion	fusion	NN
cord-258536-qnn9hp8e	17	18	of	of	IN
cord-258536-qnn9hp8e	17	19	the	the	DT
cord-258536-qnn9hp8e	17	20	viral	viral	JJ
cord-258536-qnn9hp8e	17	21	and	and	CC
cord-258536-qnn9hp8e	17	22	cellular	cellular	JJ
cord-258536-qnn9hp8e	17	23	membranes	membrane	NNS
cord-258536-qnn9hp8e	17	24	(	(	-LRB-
cord-258536-qnn9hp8e	17	25	Figure	figure	NN
cord-258536-qnn9hp8e	17	26	2	2	CD
cord-258536-qnn9hp8e	17	27	,	,	,
cord-258536-qnn9hp8e	17	28	step	step	NN
cord-258536-qnn9hp8e	17	29	1	1	CD
cord-258536-qnn9hp8e	17	30	)	)	-RRB-
cord-258536-qnn9hp8e	17	31	,	,	,
cord-258536-qnn9hp8e	17	32	which	which	WDT
cord-258536-qnn9hp8e	17	33	is	be	VBZ
cord-258536-qnn9hp8e	17	34	presumably	presumably	RB
cord-258536-qnn9hp8e	17	35	mediated	mediate	VBN
cord-258536-qnn9hp8e	17	36	by	by	IN
cord-258536-qnn9hp8e	17	37	one	one	CD
cord-258536-qnn9hp8e	17	38	of	of	IN
cord-258536-qnn9hp8e	17	39	the	the	DT
cord-258536-qnn9hp8e	17	40	surface	surface	NN
cord-258536-qnn9hp8e	17	41	glycoproteins	glycoprotein	NNS
cord-258536-qnn9hp8e	17	42	[	[	-LRB-
cord-258536-qnn9hp8e	17	43	19	19	CD
cord-258536-qnn9hp8e	17	44	,	,	,
cord-258536-qnn9hp8e	17	45	20	20	CD
cord-258536-qnn9hp8e	17	46	]	]	-RRB-
cord-258536-qnn9hp8e	17	47	.	.	.
cord-258536-qnn9hp8e	18	1	The	the	DT
cord-258536-qnn9hp8e	18	2	fusion	fusion	NN
cord-258536-qnn9hp8e	18	3	takes	take	VBZ
cord-258536-qnn9hp8e	18	4	place	place	NN
cord-258536-qnn9hp8e	18	5	either	either	CC
cord-258536-qnn9hp8e	18	6	at	at	IN
cord-258536-qnn9hp8e	18	7	the	the	DT
cord-258536-qnn9hp8e	18	8	plasma	plasma	NN
cord-258536-qnn9hp8e	18	9	membrane	membrane	NN
cord-258536-qnn9hp8e	18	10	or	or	CC
cord-258536-qnn9hp8e	18	11	in	in	IN
cord-258536-qnn9hp8e	18	12	the	the	DT
cord-258536-qnn9hp8e	18	13	endosomes	endosome	NNS
cord-258536-qnn9hp8e	18	14	and	and	CC
cord-258536-qnn9hp8e	18	15	releases	release	VBZ
cord-258536-qnn9hp8e	18	16	the	the	DT
cord-258536-qnn9hp8e	18	17	nucleocapsid	nucleocapsid	NN
cord-258536-qnn9hp8e	18	18	into	into	IN
cord-258536-qnn9hp8e	18	19	the	the	DT
cord-258536-qnn9hp8e	18	20	host	host	NN
cord-258536-qnn9hp8e	18	21	cell	cell	NN
cord-258536-qnn9hp8e	18	22	cytoplasm	cytoplasm	NN
cord-258536-qnn9hp8e	18	23	[	[	-LRB-
cord-258536-qnn9hp8e	18	24	19	19	CD
cord-258536-qnn9hp8e	18	25	]	]	-RRB-
cord-258536-qnn9hp8e	18	26	(	(	-LRB-
cord-258536-qnn9hp8e	18	27	Figure	figure	NN
cord-258536-qnn9hp8e	18	28	2	2	CD
cord-258536-qnn9hp8e	18	29	,	,	,
cord-258536-qnn9hp8e	18	30	step	step	NN
cord-258536-qnn9hp8e	18	31	1	1	CD
cord-258536-qnn9hp8e	18	32	)	)	-RRB-
cord-258536-qnn9hp8e	18	33	.	.	.
cord-258536-qnn9hp8e	19	1	After	after	IN
cord-258536-qnn9hp8e	19	2	genomic	genomic	JJ
cord-258536-qnn9hp8e	19	3	RNA	RNA	NNP
cord-258536-qnn9hp8e	19	4	uncoating	uncoate	VBG
cord-258536-qnn9hp8e	19	5	from	from	IN
cord-258536-qnn9hp8e	19	6	the	the	DT
cord-258536-qnn9hp8e	19	7	nucleocapsid	nucleocapsid	NN
cord-258536-qnn9hp8e	19	8	,	,	,
cord-258536-qnn9hp8e	19	9	two	two	CD
cord-258536-qnn9hp8e	19	10	large	large	JJ
cord-258536-qnn9hp8e	19	11	replicase	replicase	NN
cord-258536-qnn9hp8e	19	12	open	open	JJ
cord-258536-qnn9hp8e	19	13	reading	reading	NN
cord-258536-qnn9hp8e	19	14	frames	frame	NNS
cord-258536-qnn9hp8e	19	15	(	(	-LRB-
cord-258536-qnn9hp8e	19	16	ORFs	ORFs	NNP
cord-258536-qnn9hp8e	19	17	)	)	-RRB-
cord-258536-qnn9hp8e	19	18	,	,	,
cord-258536-qnn9hp8e	19	19	ORF1a	ORF1a	NNP
cord-258536-qnn9hp8e	19	20	and	and	CC
cord-258536-qnn9hp8e	19	21	ORF1b	ORF1b	NNP
cord-258536-qnn9hp8e	19	22	,	,	,
cord-258536-qnn9hp8e	19	23	are	be	VBP
cord-258536-qnn9hp8e	19	24	translated	translate	VBN
cord-258536-qnn9hp8e	19	25	by	by	IN
cord-258536-qnn9hp8e	19	26	host	host	NN
cord-258536-qnn9hp8e	19	27	ribosomes	ribosome	NNS
cord-258536-qnn9hp8e	19	28	to	to	TO
cord-258536-qnn9hp8e	19	29	yield	yield	VB
cord-258536-qnn9hp8e	19	30	two	two	CD
cord-258536-qnn9hp8e	19	31	large	large	JJ
cord-258536-qnn9hp8e	19	32	polyprotein	polyprotein	JJ
cord-258536-qnn9hp8e	19	33	precursors	precursor	NNS
cord-258536-qnn9hp8e	19	34	that	that	WDT
cord-258536-qnn9hp8e	19	35	undergo	undergo	VBP
cord-258536-qnn9hp8e	19	36	autoproteolytic	autoproteolytic	JJ
cord-258536-qnn9hp8e	19	37	processing	processing	NN
cord-258536-qnn9hp8e	19	38	to	to	TO
cord-258536-qnn9hp8e	19	39	eventually	eventually	RB
cord-258536-qnn9hp8e	19	40	produce	produce	VB
cord-258536-qnn9hp8e	19	41	the	the	DT
cord-258536-qnn9hp8e	19	42	non	non	JJ
cord-258536-qnn9hp8e	19	43	-	-	JJ
cord-258536-qnn9hp8e	19	44	structural	structural	JJ
cord-258536-qnn9hp8e	19	45	(	(	-LRB-
cord-258536-qnn9hp8e	19	46	nsp	nsp	NN
cord-258536-qnn9hp8e	19	47	)	)	-RRB-
cord-258536-qnn9hp8e	19	48	proteins	protein	NNS
cord-258536-qnn9hp8e	19	49	.	.	.
cord-258536-qnn9hp8e	20	1	The	the	DT
cord-258536-qnn9hp8e	20	2	nsp	nsp	NN
cord-258536-qnn9hp8e	20	3	proteins	protein	NNS
cord-258536-qnn9hp8e	20	4	interfere	interfere	VBP
cord-258536-qnn9hp8e	20	5	with	with	IN
cord-258536-qnn9hp8e	20	6	the	the	DT
cord-258536-qnn9hp8e	20	7	host	host	NN
cord-258536-qnn9hp8e	20	8	defenses	defense	NNS
cord-258536-qnn9hp8e	20	9	but	but	CC
cord-258536-qnn9hp8e	20	10	also	also	RB
cord-258536-qnn9hp8e	20	11	induce	induce	VBP
cord-258536-qnn9hp8e	20	12	the	the	DT
cord-258536-qnn9hp8e	20	13	formation	formation	NN
cord-258536-qnn9hp8e	20	14	of	of	IN
cord-258536-qnn9hp8e	20	15	double	double	JJ
cord-258536-qnn9hp8e	20	16	-	-	HYPH
cord-258536-qnn9hp8e	20	17	membrane	membrane	NN
cord-258536-qnn9hp8e	20	18	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	20	19	(	(	-LRB-
cord-258536-qnn9hp8e	20	20	DMVs	DMVs	NNPS
cord-258536-qnn9hp8e	20	21	)	)	-RRB-
cord-258536-qnn9hp8e	20	22	and	and	CC
cord-258536-qnn9hp8e	20	23	convoluted	convoluted	JJ
cord-258536-qnn9hp8e	20	24	membranes	membrane	NNS
cord-258536-qnn9hp8e	20	25	,	,	,
cord-258536-qnn9hp8e	20	26	on	on	IN
cord-258536-qnn9hp8e	20	27	which	which	WDT
cord-258536-qnn9hp8e	20	28	they	-PRON-	PRP
cord-258536-qnn9hp8e	20	29	collectively	collectively	RB
cord-258536-qnn9hp8e	20	30	form	form	VBP
cord-258536-qnn9hp8e	20	31	the	the	DT
cord-258536-qnn9hp8e	20	32	replication	replication	NN
cord-258536-qnn9hp8e	20	33	-	-	HYPH
cord-258536-qnn9hp8e	20	34	transcription	transcription	NN
cord-258536-qnn9hp8e	20	35	complexes	complex	NNS
cord-258536-qnn9hp8e	20	36	(	(	-LRB-
cord-258536-qnn9hp8e	20	37	RTCs	RTCs	NNP
cord-258536-qnn9hp8e	20	38	)	)	-RRB-
cord-258536-qnn9hp8e	20	39	[	[	-LRB-
cord-258536-qnn9hp8e	20	40	19	19	CD
cord-258536-qnn9hp8e	20	41	,	,	,
cord-258536-qnn9hp8e	20	42	20	20	CD
cord-258536-qnn9hp8e	20	43	]	]	-RRB-
cord-258536-qnn9hp8e	20	44	(	(	-LRB-
cord-258536-qnn9hp8e	20	45	Figure	figure	NN
cord-258536-qnn9hp8e	20	46	2	2	CD
cord-258536-qnn9hp8e	20	47	,	,	,
cord-258536-qnn9hp8e	20	48	steps	step	VBZ
cord-258536-qnn9hp8e	20	49	2	2	CD
cord-258536-qnn9hp8e	20	50	,	,	,
cord-258536-qnn9hp8e	20	51	3	3	CD
cord-258536-qnn9hp8e	20	52	,	,	,
cord-258536-qnn9hp8e	20	53	and	and	CC
cord-258536-qnn9hp8e	20	54	4	4	CD
cord-258536-qnn9hp8e	20	55	)	)	-RRB-
cord-258536-qnn9hp8e	20	56	.	.	.
cord-258536-qnn9hp8e	21	1	These	these	DT
cord-258536-qnn9hp8e	21	2	complexes	complex	NNS
cord-258536-qnn9hp8e	21	3	mediate	mediate	VBP
cord-258536-qnn9hp8e	21	4	the	the	DT
cord-258536-qnn9hp8e	21	5	synthesis	synthesis	NN
cord-258536-qnn9hp8e	21	6	of	of	IN
cord-258536-qnn9hp8e	21	7	the	the	DT
cord-258536-qnn9hp8e	21	8	genomic	genomic	JJ
cord-258536-qnn9hp8e	21	9	RNA	RNA	NNP
cord-258536-qnn9hp8e	21	10	and	and	CC
cord-258536-qnn9hp8e	21	11	a	a	DT
cord-258536-qnn9hp8e	21	12	nested	nest	VBN
cord-258536-qnn9hp8e	21	13	set	set	NN
cord-258536-qnn9hp8e	21	14	of	of	IN
cord-258536-qnn9hp8e	21	15	subgenomic	subgenomic	NNP
cord-258536-qnn9hp8e	21	16	RNAs	RNAs	NNPS
cord-258536-qnn9hp8e	21	17	that	that	WDT
cord-258536-qnn9hp8e	21	18	directs	direct	VBZ
cord-258536-qnn9hp8e	21	19	the	the	DT
cord-258536-qnn9hp8e	21	20	translation	translation	NN
cord-258536-qnn9hp8e	21	21	of	of	IN
cord-258536-qnn9hp8e	21	22	the	the	DT
cord-258536-qnn9hp8e	21	23	structural	structural	JJ
cord-258536-qnn9hp8e	21	24	proteins	protein	NNS
cord-258536-qnn9hp8e	21	25	(	(	-LRB-
cord-258536-qnn9hp8e	21	26	the	the	DT
cord-258536-qnn9hp8e	21	27	nucleocapsid	nucleocapsid	NN
cord-258536-qnn9hp8e	21	28	N	n	CD
cord-258536-qnn9hp8e	21	29	protein	protein	NN
cord-258536-qnn9hp8e	21	30	,	,	,
cord-258536-qnn9hp8e	21	31	the	the	DT
cord-258536-qnn9hp8e	21	32	membrane	membrane	NN
cord-258536-qnn9hp8e	21	33	M	M	NNP
cord-258536-qnn9hp8e	21	34	protein	protein	NN
cord-258536-qnn9hp8e	21	35	,	,	,
cord-258536-qnn9hp8e	21	36	the	the	DT
cord-258536-qnn9hp8e	21	37	envelope	envelope	NN
cord-258536-qnn9hp8e	21	38	E	e	NN
cord-258536-qnn9hp8e	21	39	protein	protein	NN
cord-258536-qnn9hp8e	21	40	and	and	CC
cord-258536-qnn9hp8e	21	41	the	the	DT
cord-258536-qnn9hp8e	21	42	spike	spike	NN
cord-258536-qnn9hp8e	21	43	S	s	NN
cord-258536-qnn9hp8e	21	44	protein	protein	NN
cord-258536-qnn9hp8e	21	45	)	)	-RRB-
cord-258536-qnn9hp8e	21	46	and	and	CC
cord-258536-qnn9hp8e	21	47	some	some	DT
cord-258536-qnn9hp8e	21	48	accessory	accessory	NN
cord-258536-qnn9hp8e	21	49	proteins	protein	NNS
cord-258536-qnn9hp8e	21	50	,	,	,
cord-258536-qnn9hp8e	21	51	like	like	IN
cord-258536-qnn9hp8e	21	52	the	the	DT
cord-258536-qnn9hp8e	21	53	hemagglutinin	hemagglutinin	NN
cord-258536-qnn9hp8e	21	54	esterase	esterase	NN
cord-258536-qnn9hp8e	21	55	in	in	IN
cord-258536-qnn9hp8e	21	56	the	the	DT
cord-258536-qnn9hp8e	21	57	case	case	NN
cord-258536-qnn9hp8e	21	58	of	of	IN
cord-258536-qnn9hp8e	21	59	Severe	severe	JJ
cord-258536-qnn9hp8e	21	60	Acute	acute	JJ
cord-258536-qnn9hp8e	21	61	Respiratory	Respiratory	NNP
cord-258536-qnn9hp8e	21	62	Syndrome	Syndrome	NNP
cord-258536-qnn9hp8e	21	63	(	(	-LRB-
cord-258536-qnn9hp8e	21	64	SARS)-CoV	SARS)-CoV	NNP
cord-258536-qnn9hp8e	21	65	or	or	CC
cord-258536-qnn9hp8e	21	66	Mouse	Mouse	NNP
cord-258536-qnn9hp8e	21	67	Hepatitis	Hepatitis	NNP
cord-258536-qnn9hp8e	21	68	Virus	Virus	NNP
cord-258536-qnn9hp8e	21	69	(	(	-LRB-
cord-258536-qnn9hp8e	21	70	MHV	MHV	NNP
cord-258536-qnn9hp8e	21	71	)	)	-RRB-
cord-258536-qnn9hp8e	21	72	[	[	-LRB-
cord-258536-qnn9hp8e	21	73	21	21	CD
cord-258536-qnn9hp8e	21	74	]	]	-RRB-
cord-258536-qnn9hp8e	21	75	[	[	-LRB-
cord-258536-qnn9hp8e	21	76	22	22	CD
cord-258536-qnn9hp8e	21	77	]	]	-RRB-
cord-258536-qnn9hp8e	21	78	[	[	-LRB-
cord-258536-qnn9hp8e	21	79	23	23	CD
cord-258536-qnn9hp8e	21	80	]	]	-RRB-
cord-258536-qnn9hp8e	21	81	(	(	-LRB-
cord-258536-qnn9hp8e	21	82	Figure	figure	NN
cord-258536-qnn9hp8e	21	83	2	2	CD
cord-258536-qnn9hp8e	21	84	,	,	,
cord-258536-qnn9hp8e	21	85	steps	step	VBZ
cord-258536-qnn9hp8e	21	86	5	5	CD
cord-258536-qnn9hp8e	21	87	and	and	CC
cord-258536-qnn9hp8e	21	88	6	6	CD
cord-258536-qnn9hp8e	21	89	)	)	-RRB-
cord-258536-qnn9hp8e	21	90	.	.	.
cord-258536-qnn9hp8e	22	1	Newly	newly	RB
cord-258536-qnn9hp8e	22	2	synthesized	synthesize	VBN
cord-258536-qnn9hp8e	22	3	genomic	genomic	JJ
cord-258536-qnn9hp8e	22	4	RNAs	rna	NNS
cord-258536-qnn9hp8e	22	5	associate	associate	VBP
cord-258536-qnn9hp8e	22	6	with	with	IN
cord-258536-qnn9hp8e	22	7	the	the	DT
cord-258536-qnn9hp8e	22	8	cytoplasmic	cytoplasmic	JJ
cord-258536-qnn9hp8e	22	9	nucleocapsid	nucleocapsid	NN
cord-258536-qnn9hp8e	22	10	proteins	protein	NNS
cord-258536-qnn9hp8e	22	11	to	to	TO
cord-258536-qnn9hp8e	22	12	generate	generate	VB
cord-258536-qnn9hp8e	22	13	the	the	DT
cord-258536-qnn9hp8e	22	14	so	so	RB
cord-258536-qnn9hp8e	22	15	-	-	HYPH
cord-258536-qnn9hp8e	22	16	called	call	VBN
cord-258536-qnn9hp8e	22	17	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	22	18	complexes	complex	NNS
cord-258536-qnn9hp8e	22	19	[	[	-LRB-
cord-258536-qnn9hp8e	22	20	20	20	CD
cord-258536-qnn9hp8e	22	21	,	,	,
cord-258536-qnn9hp8e	22	22	22	22	CD
cord-258536-qnn9hp8e	22	23	]	]	-RRB-
cord-258536-qnn9hp8e	22	24	.	.	.
cord-258536-qnn9hp8e	23	1	The	the	DT
cord-258536-qnn9hp8e	23	2	viral	viral	JJ
cord-258536-qnn9hp8e	23	3	structural	structural	JJ
cord-258536-qnn9hp8e	23	4	envelope	envelope	NN
cord-258536-qnn9hp8e	23	5	proteins	protein	NNS
cord-258536-qnn9hp8e	23	6	are	be	VBP
cord-258536-qnn9hp8e	23	7	inserted	insert	VBN
cord-258536-qnn9hp8e	23	8	into	into	IN
cord-258536-qnn9hp8e	23	9	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	23	10	reticulum	reticulum	NN
cord-258536-qnn9hp8e	23	11	(	(	-LRB-
cord-258536-qnn9hp8e	23	12	ER	ER	NNP
cord-258536-qnn9hp8e	23	13	)	)	-RRB-
cord-258536-qnn9hp8e	23	14	and	and	CC
cord-258536-qnn9hp8e	23	15	targeted	target	VBN
cord-258536-qnn9hp8e	23	16	to	to	IN
cord-258536-qnn9hp8e	23	17	the	the	DT
cord-258536-qnn9hp8e	23	18	site	site	NN
cord-258536-qnn9hp8e	23	19	of	of	IN
cord-258536-qnn9hp8e	23	20	virus	virus	NN
cord-258536-qnn9hp8e	23	21	assembly	assembly	NN
cord-258536-qnn9hp8e	23	22	,	,	,
cord-258536-qnn9hp8e	23	23	the	the	DT
cord-258536-qnn9hp8e	23	24	ER	ER	NNP
cord-258536-qnn9hp8e	23	25	,	,	,
cord-258536-qnn9hp8e	23	26	or	or	CC
cord-258536-qnn9hp8e	23	27	the	the	DT
cord-258536-qnn9hp8e	23	28	Golgi	Golgi	NNP
cord-258536-qnn9hp8e	23	29	,	,	,
cord-258536-qnn9hp8e	23	30	where	where	WRB
cord-258536-qnn9hp8e	23	31	they	-PRON-	PRP
cord-258536-qnn9hp8e	23	32	interact	interact	VBP
cord-258536-qnn9hp8e	23	33	with	with	IN
cord-258536-qnn9hp8e	23	34	the	the	DT
cord-258536-qnn9hp8e	23	35	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	23	36	complex	complex	NN
cord-258536-qnn9hp8e	23	37	to	to	TO
cord-258536-qnn9hp8e	23	38	initiate	initiate	VB
cord-258536-qnn9hp8e	23	39	the	the	DT
cord-258536-qnn9hp8e	23	40	budding	budding	NN
cord-258536-qnn9hp8e	23	41	of	of	IN
cord-258536-qnn9hp8e	23	42	virus	virus	NN
cord-258536-qnn9hp8e	23	43	particles	particle	NNS
cord-258536-qnn9hp8e	23	44	into	into	IN
cord-258536-qnn9hp8e	23	45	the	the	DT
cord-258536-qnn9hp8e	23	46	lumen	lumen	NN
cord-258536-qnn9hp8e	23	47	of	of	IN
cord-258536-qnn9hp8e	23	48	the	the	DT
cord-258536-qnn9hp8e	23	49	membrane	membrane	NN
cord-258536-qnn9hp8e	23	50	compartment	compartment	NN
cord-258536-qnn9hp8e	23	51	[	[	-LRB-
cord-258536-qnn9hp8e	23	52	20	20	CD
cord-258536-qnn9hp8e	23	53	,	,	,
cord-258536-qnn9hp8e	23	54	24	24	CD
cord-258536-qnn9hp8e	23	55	,	,	,
cord-258536-qnn9hp8e	23	56	25	25	CD
cord-258536-qnn9hp8e	23	57	]	]	-RRB-
cord-258536-qnn9hp8e	24	1	(	(	-LRB-
cord-258536-qnn9hp8e	24	2	Figure	figure	NN
cord-258536-qnn9hp8e	24	3	2	2	CD
cord-258536-qnn9hp8e	24	4	,	,	,
cord-258536-qnn9hp8e	24	5	steps	step	VBZ
cord-258536-qnn9hp8e	24	6	7	7	CD
cord-258536-qnn9hp8e	24	7	,	,	,
cord-258536-qnn9hp8e	24	8	8	8	CD
cord-258536-qnn9hp8e	24	9	and	and	CC
cord-258536-qnn9hp8e	24	10	9	9	CD
cord-258536-qnn9hp8e	24	11	)	)	-RRB-
cord-258536-qnn9hp8e	24	12	.	.	.
cord-258536-qnn9hp8e	25	1	Newly	newly	RB
cord-258536-qnn9hp8e	25	2	formed	form	VBN
cord-258536-qnn9hp8e	25	3	virions	virion	NNS
cord-258536-qnn9hp8e	25	4	then	then	RB
cord-258536-qnn9hp8e	25	5	egress	egress	VB
cord-258536-qnn9hp8e	25	6	the	the	DT
cord-258536-qnn9hp8e	25	7	host	host	NN
cord-258536-qnn9hp8e	25	8	cell	cell	NN
cord-258536-qnn9hp8e	25	9	through	through	IN
cord-258536-qnn9hp8e	25	10	secretion	secretion	NN
cord-258536-qnn9hp8e	25	11	via	via	IN
cord-258536-qnn9hp8e	25	12	the	the	DT
cord-258536-qnn9hp8e	25	13	exocytic	exocytic	JJ
cord-258536-qnn9hp8e	25	14	pathway	pathway	NN
cord-258536-qnn9hp8e	25	15	[	[	-LRB-
cord-258536-qnn9hp8e	25	16	20	20	CD
cord-258536-qnn9hp8e	25	17	,	,	,
cord-258536-qnn9hp8e	25	18	24	24	CD
cord-258536-qnn9hp8e	25	19	]	]	-RRB-
cord-258536-qnn9hp8e	26	1	(	(	-LRB-
cord-258536-qnn9hp8e	26	2	Figure	figure	NN
cord-258536-qnn9hp8e	26	3	2	2	CD
cord-258536-qnn9hp8e	26	4	,	,	,
cord-258536-qnn9hp8e	26	5	step	step	VB
cord-258536-qnn9hp8e	26	6	10	10	CD
cord-258536-qnn9hp8e	26	7	)	)	-RRB-
cord-258536-qnn9hp8e	26	8	.	.	.
cord-258536-qnn9hp8e	27	1	Viruses	virus	NNS
cord-258536-qnn9hp8e	27	2	2017	2017	CD
cord-258536-qnn9hp8e	27	3	,	,	,
cord-258536-qnn9hp8e	27	4	9	9	CD
cord-258536-qnn9hp8e	27	5	,	,	,
cord-258536-qnn9hp8e	27	6	182	182	CD
cord-258536-qnn9hp8e	27	7	3	3	CD
cord-258536-qnn9hp8e	27	8	of	of	IN
cord-258536-qnn9hp8e	27	9	14	14	CD
cord-258536-qnn9hp8e	27	10	they	-PRON-	PRP
cord-258536-qnn9hp8e	27	11	interact	interact	VBP
cord-258536-qnn9hp8e	27	12	with	with	IN
cord-258536-qnn9hp8e	27	13	the	the	DT
cord-258536-qnn9hp8e	27	14	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	27	15	complex	complex	NN
cord-258536-qnn9hp8e	27	16	to	to	TO
cord-258536-qnn9hp8e	27	17	initiate	initiate	VB
cord-258536-qnn9hp8e	27	18	the	the	DT
cord-258536-qnn9hp8e	27	19	budding	budding	NN
cord-258536-qnn9hp8e	27	20	of	of	IN
cord-258536-qnn9hp8e	27	21	virus	virus	NN
cord-258536-qnn9hp8e	27	22	particles	particle	NNS
cord-258536-qnn9hp8e	27	23	into	into	IN
cord-258536-qnn9hp8e	27	24	the	the	DT
cord-258536-qnn9hp8e	27	25	lumen	lumen	NN
cord-258536-qnn9hp8e	27	26	of	of	IN
cord-258536-qnn9hp8e	27	27	the	the	DT
cord-258536-qnn9hp8e	27	28	membrane	membrane	NN
cord-258536-qnn9hp8e	27	29	compartment	compartment	NN
cord-258536-qnn9hp8e	27	30	[	[	-LRB-
cord-258536-qnn9hp8e	27	31	20	20	CD
cord-258536-qnn9hp8e	27	32	,	,	,
cord-258536-qnn9hp8e	27	33	24	24	CD
cord-258536-qnn9hp8e	27	34	,	,	,
cord-258536-qnn9hp8e	27	35	25	25	CD
cord-258536-qnn9hp8e	27	36	]	]	-RRB-
cord-258536-qnn9hp8e	27	37	(	(	-LRB-
cord-258536-qnn9hp8e	27	38	Figure	figure	NN
cord-258536-qnn9hp8e	27	39	2	2	CD
cord-258536-qnn9hp8e	27	40	,	,	,
cord-258536-qnn9hp8e	27	41	steps	step	VBZ
cord-258536-qnn9hp8e	27	42	7	7	CD
cord-258536-qnn9hp8e	27	43	,	,	,
cord-258536-qnn9hp8e	27	44	8	8	CD
cord-258536-qnn9hp8e	27	45	and	and	CC
cord-258536-qnn9hp8e	27	46	9	9	CD
cord-258536-qnn9hp8e	27	47	)	)	-RRB-
cord-258536-qnn9hp8e	27	48	.	.	.
cord-258536-qnn9hp8e	28	1	Newly	newly	RB
cord-258536-qnn9hp8e	28	2	formed	form	VBN
cord-258536-qnn9hp8e	28	3	virions	virion	NNS
cord-258536-qnn9hp8e	28	4	then	then	RB
cord-258536-qnn9hp8e	28	5	egress	egress	VB
cord-258536-qnn9hp8e	28	6	the	the	DT
cord-258536-qnn9hp8e	28	7	host	host	NN
cord-258536-qnn9hp8e	28	8	cell	cell	NN
cord-258536-qnn9hp8e	28	9	through	through	IN
cord-258536-qnn9hp8e	28	10	secretion	secretion	NN
cord-258536-qnn9hp8e	28	11	via	via	IN
cord-258536-qnn9hp8e	28	12	the	the	DT
cord-258536-qnn9hp8e	28	13	exocytic	exocytic	JJ
cord-258536-qnn9hp8e	28	14	pathway	pathway	NN
cord-258536-qnn9hp8e	28	15	[	[	-LRB-
cord-258536-qnn9hp8e	28	16	20	20	CD
cord-258536-qnn9hp8e	28	17	,	,	,
cord-258536-qnn9hp8e	28	18	24	24	CD
cord-258536-qnn9hp8e	28	19	]	]	-RRB-
cord-258536-qnn9hp8e	29	1	(	(	-LRB-
cord-258536-qnn9hp8e	29	2	Figure	figure	NN
cord-258536-qnn9hp8e	29	3	2	2	CD
cord-258536-qnn9hp8e	29	4	,	,	,
cord-258536-qnn9hp8e	29	5	step	step	VB
cord-258536-qnn9hp8e	29	6	10	10	CD
cord-258536-qnn9hp8e	29	7	)	)	-RRB-
cord-258536-qnn9hp8e	29	8	.	.	.
cord-258536-qnn9hp8e	30	1	Generalization	generalization	NN
cord-258536-qnn9hp8e	30	2	of	of	IN
cord-258536-qnn9hp8e	30	3	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	30	4	life	life	NN
cord-258536-qnn9hp8e	30	5	cycle	cycle	NN
cord-258536-qnn9hp8e	30	6	,	,	,
cord-258536-qnn9hp8e	30	7	based	base	VBN
cord-258536-qnn9hp8e	30	8	on	on	IN
cord-258536-qnn9hp8e	30	9	the	the	DT
cord-258536-qnn9hp8e	30	10	information	information	NN
cord-258536-qnn9hp8e	30	11	acquired	acquire	VBD
cord-258536-qnn9hp8e	30	12	studying	study	VBG
cord-258536-qnn9hp8e	30	13	Arteriviruses	Arteriviruses	NNP
cord-258536-qnn9hp8e	30	14	and	and	CC
cord-258536-qnn9hp8e	30	15	Coronaviruses	Coronaviruses	NNP
cord-258536-qnn9hp8e	30	16	.	.	.
cord-258536-qnn9hp8e	31	1	Infection	infection	NN
cord-258536-qnn9hp8e	31	2	starts	start	VBZ
cord-258536-qnn9hp8e	31	3	with	with	IN
cord-258536-qnn9hp8e	31	4	the	the	DT
cord-258536-qnn9hp8e	31	5	binding	binding	NN
cord-258536-qnn9hp8e	31	6	of	of	IN
cord-258536-qnn9hp8e	31	7	the	the	DT
cord-258536-qnn9hp8e	31	8	viral	viral	JJ
cord-258536-qnn9hp8e	31	9	particle	particle	NN
cord-258536-qnn9hp8e	31	10	to	to	IN
cord-258536-qnn9hp8e	31	11	a	a	DT
cord-258536-qnn9hp8e	31	12	cell	cell	NN
cord-258536-qnn9hp8e	31	13	surface	surface	NN
cord-258536-qnn9hp8e	31	14	receptor	receptor	NN
cord-258536-qnn9hp8e	31	15	and	and	CC
cord-258536-qnn9hp8e	31	16	subsequent	subsequent	JJ
cord-258536-qnn9hp8e	31	17	cell	cell	NN
cord-258536-qnn9hp8e	31	18	entry	entry	NN
cord-258536-qnn9hp8e	31	19	through	through	IN
cord-258536-qnn9hp8e	31	20	membrane	membrane	NN
cord-258536-qnn9hp8e	31	21	fusion	fusion	NN
cord-258536-qnn9hp8e	31	22	in	in	IN
cord-258536-qnn9hp8e	31	23	endosomes	endosome	NNS
cord-258536-qnn9hp8e	31	24	upon	upon	IN
cord-258536-qnn9hp8e	31	25	endocytosis	endocytosis	NN
cord-258536-qnn9hp8e	31	26	(	(	-LRB-
cord-258536-qnn9hp8e	31	27	step	step	NN
cord-258536-qnn9hp8e	31	28	1	1	CD
cord-258536-qnn9hp8e	31	29	)	)	-RRB-
cord-258536-qnn9hp8e	31	30	.	.	.
cord-258536-qnn9hp8e	32	1	Translation	translation	NN
cord-258536-qnn9hp8e	32	2	of	of	IN
cord-258536-qnn9hp8e	32	3	the	the	DT
cord-258536-qnn9hp8e	32	4	released	release	VBN
cord-258536-qnn9hp8e	32	5	genomic	genomic	JJ
cord-258536-qnn9hp8e	32	6	RNA	RNA	NNP
cord-258536-qnn9hp8e	32	7	(	(	-LRB-
cord-258536-qnn9hp8e	32	8	gRNA	gRNA	NNP
cord-258536-qnn9hp8e	32	9	)	)	-RRB-
cord-258536-qnn9hp8e	32	10	yields	yield	VBZ
cord-258536-qnn9hp8e	32	11	replicase	replicase	NNP
cord-258536-qnn9hp8e	32	12	polyproteins	polyproteins	NNP
cord-258536-qnn9hp8e	32	13	(	(	-LRB-
cord-258536-qnn9hp8e	32	14	step	step	NNP
cord-258536-qnn9hp8e	32	15	2	2	CD
cord-258536-qnn9hp8e	32	16	)	)	-RRB-
cord-258536-qnn9hp8e	32	17	,	,	,
cord-258536-qnn9hp8e	32	18	i.e.	i.e.	FW
cord-258536-qnn9hp8e	32	19	,	,	,
cord-258536-qnn9hp8e	32	20	polyprotein	polyprotein	NNP
cord-258536-qnn9hp8e	32	21	1a	1a	CD
cord-258536-qnn9hp8e	32	22	(	(	-LRB-
cord-258536-qnn9hp8e	32	23	pp1a	pp1a	NNP
cord-258536-qnn9hp8e	32	24	)	)	-RRB-
cord-258536-qnn9hp8e	32	25	and	and	CC
cord-258536-qnn9hp8e	32	26	polyprotein	polyprotein	JJ
cord-258536-qnn9hp8e	32	27	1ab	1ab	NNP
cord-258536-qnn9hp8e	32	28	(	(	-LRB-
cord-258536-qnn9hp8e	32	29	pp1ab	pp1ab	NNP
cord-258536-qnn9hp8e	32	30	)	)	-RRB-
cord-258536-qnn9hp8e	32	31	,	,	,
cord-258536-qnn9hp8e	32	32	which	which	WDT
cord-258536-qnn9hp8e	32	33	undergo	undergo	VBP
cord-258536-qnn9hp8e	32	34	autoproteolytic	autoproteolytic	JJ
cord-258536-qnn9hp8e	32	35	processing	processing	NN
cord-258536-qnn9hp8e	32	36	to	to	TO
cord-258536-qnn9hp8e	32	37	generate	generate	VB
cord-258536-qnn9hp8e	32	38	nonstructural	nonstructural	JJ
cord-258536-qnn9hp8e	32	39	proteins	protein	NNS
cord-258536-qnn9hp8e	32	40	that	that	WDT
cord-258536-qnn9hp8e	32	41	assemble	assemble	VBP
cord-258536-qnn9hp8e	32	42	into	into	IN
cord-258536-qnn9hp8e	32	43	replication	replication	NN
cord-258536-qnn9hp8e	32	44	-	-	HYPH
cord-258536-qnn9hp8e	32	45	transcription	transcription	NN
cord-258536-qnn9hp8e	32	46	complexes	complex	NNS
cord-258536-qnn9hp8e	32	47	(	(	-LRB-
cord-258536-qnn9hp8e	32	48	RTCs	RTCs	NNP
cord-258536-qnn9hp8e	32	49	)	)	-RRB-
cord-258536-qnn9hp8e	32	50	.	.	.
cord-258536-qnn9hp8e	33	1	The	the	DT
cord-258536-qnn9hp8e	33	2	RTCs	rtc	NNS
cord-258536-qnn9hp8e	33	3	are	be	VBP
cord-258536-qnn9hp8e	33	4	part	part	NN
cord-258536-qnn9hp8e	33	5	of	of	IN
cord-258536-qnn9hp8e	33	6	a	a	DT
cord-258536-qnn9hp8e	33	7	complex	complex	JJ
cord-258536-qnn9hp8e	33	8	membranous	membranous	JJ
cord-258536-qnn9hp8e	33	9	network	network	NN
cord-258536-qnn9hp8e	33	10	composed	compose	VBN
cord-258536-qnn9hp8e	33	11	of	of	IN
cord-258536-qnn9hp8e	33	12	double	double	JJ
cord-258536-qnn9hp8e	33	13	membrane	membrane	NN
cord-258536-qnn9hp8e	33	14	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	33	15	(	(	-LRB-
cord-258536-qnn9hp8e	33	16	DMVs	dmv	NNS
cord-258536-qnn9hp8e	33	17	)	)	-RRB-
cord-258536-qnn9hp8e	33	18	and	and	CC
cord-258536-qnn9hp8e	33	19	convoluted	convoluted	JJ
cord-258536-qnn9hp8e	33	20	membranes	membrane	NNS
cord-258536-qnn9hp8e	33	21	(	(	-LRB-
cord-258536-qnn9hp8e	33	22	step	step	NN
cord-258536-qnn9hp8e	33	23	4	4	CD
cord-258536-qnn9hp8e	33	24	)	)	-RRB-
cord-258536-qnn9hp8e	33	25	.	.	.
cord-258536-qnn9hp8e	34	1	The	the	DT
cord-258536-qnn9hp8e	34	2	RTCs	rtc	NNS
cord-258536-qnn9hp8e	34	3	first	first	RB
cord-258536-qnn9hp8e	34	4	engage	engage	VBP
cord-258536-qnn9hp8e	34	5	in	in	IN
cord-258536-qnn9hp8e	34	6	minus	minus	JJ
cord-258536-qnn9hp8e	34	7	-	-	HYPH
cord-258536-qnn9hp8e	34	8	strand	strand	NN
cord-258536-qnn9hp8e	34	9	RNA	RNA	NNP
cord-258536-qnn9hp8e	34	10	synthesis	synthesis	NN
cord-258536-qnn9hp8e	34	11	to	to	TO
cord-258536-qnn9hp8e	34	12	produce	produce	VB
cord-258536-qnn9hp8e	34	13	both	both	DT
cord-258536-qnn9hp8e	34	14	single	single	JJ
cord-258536-qnn9hp8e	34	15	strand	strand	NN
cord-258536-qnn9hp8e	34	16	full	full	JJ
cord-258536-qnn9hp8e	34	17	-	-	HYPH
cord-258536-qnn9hp8e	34	18	length	length	NN
cord-258536-qnn9hp8e	34	19	and	and	CC
cord-258536-qnn9hp8e	34	20	subgenomic	subgenomic	NNP
cord-258536-qnn9hp8e	34	21	(	(	-LRB-
cord-258536-qnn9hp8e	34	22	sg	sg	NNP
cord-258536-qnn9hp8e	34	23	)	)	-RRB-
cord-258536-qnn9hp8e	34	24	minus	minus	JJ
cord-258536-qnn9hp8e	34	25	-	-	HYPH
cord-258536-qnn9hp8e	34	26	strand	strand	NN
cord-258536-qnn9hp8e	34	27	RNAs	rna	NNS
cord-258536-qnn9hp8e	34	28	(	(	-LRB-
cord-258536-qnn9hp8e	34	29	step	step	NN
cord-258536-qnn9hp8e	34	30	5	5	CD
cord-258536-qnn9hp8e	34	31	)	)	-RRB-
cord-258536-qnn9hp8e	34	32	.	.	.
cord-258536-qnn9hp8e	35	1	Subsequently	subsequently	RB
cord-258536-qnn9hp8e	35	2	,	,	,
cord-258536-qnn9hp8e	35	3	they	-PRON-	PRP
cord-258536-qnn9hp8e	35	4	use	use	VBP
cord-258536-qnn9hp8e	35	5	sg	sg	NNP
cord-258536-qnn9hp8e	35	6	mRNAs	mRNAs	NNP
cord-258536-qnn9hp8e	35	7	as	as	IN
cord-258536-qnn9hp8e	35	8	templates	template	NNS
cord-258536-qnn9hp8e	35	9	for	for	IN
cord-258536-qnn9hp8e	35	10	the	the	DT
cord-258536-qnn9hp8e	35	11	production	production	NN
cord-258536-qnn9hp8e	35	12	of	of	IN
cord-258536-qnn9hp8e	35	13	the	the	DT
cord-258536-qnn9hp8e	35	14	gRNA	gRNA	NNS
cord-258536-qnn9hp8e	35	15	and	and	CC
cord-258536-qnn9hp8e	35	16	plus	plus	JJ
cord-258536-qnn9hp8e	35	17	-	-	HYPH
cord-258536-qnn9hp8e	35	18	strand	strand	NN
cord-258536-qnn9hp8e	35	19	sg	sg	NNP
cord-258536-qnn9hp8e	35	20	mRNAs	mRNAs	NNP
cord-258536-qnn9hp8e	35	21	required	require	VBD
cord-258536-qnn9hp8e	35	22	to	to	TO
cord-258536-qnn9hp8e	35	23	express	express	VB
cord-258536-qnn9hp8e	35	24	the	the	DT
cord-258536-qnn9hp8e	35	25	structural	structural	JJ
cord-258536-qnn9hp8e	35	26	protein	protein	NN
cord-258536-qnn9hp8e	35	27	genes	gene	NNS
cord-258536-qnn9hp8e	35	28	(	(	-LRB-
cord-258536-qnn9hp8e	35	29	step	step	NNP
cord-258536-qnn9hp8e	35	30	6	6	CD
cord-258536-qnn9hp8e	35	31	)	)	-RRB-
cord-258536-qnn9hp8e	35	32	.	.	.
cord-258536-qnn9hp8e	36	1	Newly	newly	RB
cord-258536-qnn9hp8e	36	2	synthesized	synthesize	VBN
cord-258536-qnn9hp8e	36	3	S	S	NNP
cord-258536-qnn9hp8e	36	4	,	,	,
cord-258536-qnn9hp8e	36	5	E	E	NNP
cord-258536-qnn9hp8e	36	6	,	,	,
cord-258536-qnn9hp8e	36	7	and	and	CC
cord-258536-qnn9hp8e	36	8	M	M	NNP
cord-258536-qnn9hp8e	36	9	structural	structural	JJ
cord-258536-qnn9hp8e	36	10	proteins	protein	NNS
cord-258536-qnn9hp8e	36	11	are	be	VBP
cord-258536-qnn9hp8e	36	12	inserted	insert	VBN
cord-258536-qnn9hp8e	36	13	in	in	IN
cord-258536-qnn9hp8e	36	14	the	the	DT
cord-258536-qnn9hp8e	36	15	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	36	16	reticulum	reticulum	NN
cord-258536-qnn9hp8e	36	17	(	(	-LRB-
cord-258536-qnn9hp8e	36	18	ER	ER	NNP
cord-258536-qnn9hp8e	36	19	)	)	-RRB-
cord-258536-qnn9hp8e	36	20	(	(	-LRB-
cord-258536-qnn9hp8e	36	21	steps	step	VBZ
cord-258536-qnn9hp8e	36	22	7	7	CD
cord-258536-qnn9hp8e	36	23	and	and	CC
cord-258536-qnn9hp8e	36	24	8)	8)	NN
cord-258536-qnn9hp8e	36	25	,	,	,
cord-258536-qnn9hp8e	36	26	whereas	whereas	IN
cord-258536-qnn9hp8e	36	27	the	the	DT
cord-258536-qnn9hp8e	36	28	N	n	CD
cord-258536-qnn9hp8e	36	29	nucleocapsides	nucleocapside	NNS
cord-258536-qnn9hp8e	36	30	are	be	VBP
cord-258536-qnn9hp8e	36	31	translated	translate	VBN
cord-258536-qnn9hp8e	36	32	and	and	CC
cord-258536-qnn9hp8e	36	33	oligomerize	oligomerize	NN
cord-258536-qnn9hp8e	36	34	in	in	IN
cord-258536-qnn9hp8e	36	35	the	the	DT
cord-258536-qnn9hp8e	36	36	cytosol	cytosol	NN
cord-258536-qnn9hp8e	36	37	,	,	,
cord-258536-qnn9hp8e	36	38	where	where	WRB
cord-258536-qnn9hp8e	36	39	they	-PRON-	PRP
cord-258536-qnn9hp8e	36	40	interact	interact	VBP
cord-258536-qnn9hp8e	36	41	with	with	IN
cord-258536-qnn9hp8e	36	42	RTCs	rtc	NNS
cord-258536-qnn9hp8e	36	43	and	and	CC
cord-258536-qnn9hp8e	36	44	associate	associate	VB
cord-258536-qnn9hp8e	36	45	with	with	IN
cord-258536-qnn9hp8e	36	46	the	the	DT
cord-258536-qnn9hp8e	36	47	gRNA	gRNA	NNS
cord-258536-qnn9hp8e	36	48	to	to	TO
cord-258536-qnn9hp8e	36	49	form	form	VB
cord-258536-qnn9hp8e	36	50	the	the	DT
cord-258536-qnn9hp8e	36	51	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	36	52	complexes	complex	NNS
cord-258536-qnn9hp8e	36	53	(	(	-LRB-
cord-258536-qnn9hp8e	36	54	step	step	NNP
cord-258536-qnn9hp8e	36	55	7	7	CD
cord-258536-qnn9hp8e	36	56	)	)	-RRB-
cord-258536-qnn9hp8e	36	57	.	.	.
cord-258536-qnn9hp8e	37	1	Virion	virion	NN
cord-258536-qnn9hp8e	37	2	assembly	assembly	NN
cord-258536-qnn9hp8e	37	3	takes	take	VBZ
cord-258536-qnn9hp8e	37	4	place	place	NN
cord-258536-qnn9hp8e	37	5	in	in	IN
cord-258536-qnn9hp8e	37	6	the	the	DT
cord-258536-qnn9hp8e	37	7	ER	ER	NNP
cord-258536-qnn9hp8e	37	8	and/or	and/or	CC
cord-258536-qnn9hp8e	37	9	Golgi	Golgi	NNP
cord-258536-qnn9hp8e	37	10	(	(	-LRB-
cord-258536-qnn9hp8e	37	11	step	step	NN
cord-258536-qnn9hp8e	37	12	9	9	CD
cord-258536-qnn9hp8e	37	13	)	)	-RRB-
cord-258536-qnn9hp8e	37	14	,	,	,
cord-258536-qnn9hp8e	37	15	and	and	CC
cord-258536-qnn9hp8e	37	16	involves	involve	VBZ
cord-258536-qnn9hp8e	37	17	the	the	DT
cord-258536-qnn9hp8e	37	18	inward	inward	JJ
cord-258536-qnn9hp8e	37	19	budding	budding	NN
cord-258536-qnn9hp8e	37	20	of	of	IN
cord-258536-qnn9hp8e	37	21	the	the	DT
cord-258536-qnn9hp8e	37	22	limiting	limit	VBG
cord-258536-qnn9hp8e	37	23	membrane	membrane	NN
cord-258536-qnn9hp8e	37	24	of	of	IN
cord-258536-qnn9hp8e	37	25	these	these	DT
cord-258536-qnn9hp8e	37	26	compartments	compartment	NNS
cord-258536-qnn9hp8e	37	27	,	,	,
cord-258536-qnn9hp8e	37	28	which	which	WDT
cord-258536-qnn9hp8e	37	29	is	be	VBZ
cord-258536-qnn9hp8e	37	30	triggered	trigger	VBN
cord-258536-qnn9hp8e	37	31	by	by	IN
cord-258536-qnn9hp8e	37	32	the	the	DT
cord-258536-qnn9hp8e	37	33	interaction	interaction	NN
cord-258536-qnn9hp8e	37	34	between	between	IN
cord-258536-qnn9hp8e	37	35	the	the	DT
cord-258536-qnn9hp8e	37	36	structural	structural	JJ
cord-258536-qnn9hp8e	37	37	proteins	protein	NNS
cord-258536-qnn9hp8e	37	38	and	and	CC
cord-258536-qnn9hp8e	37	39	the	the	DT
cord-258536-qnn9hp8e	37	40	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	37	41	complexes	complex	NNS
cord-258536-qnn9hp8e	37	42	.	.	.
cord-258536-qnn9hp8e	38	1	Mature	mature	JJ
cord-258536-qnn9hp8e	38	2	virions	virion	NNS
cord-258536-qnn9hp8e	38	3	are	be	VBP
cord-258536-qnn9hp8e	38	4	released	release	VBN
cord-258536-qnn9hp8e	38	5	extracellularly	extracellularly	RB
cord-258536-qnn9hp8e	38	6	by	by	IN
cord-258536-qnn9hp8e	38	7	exocytosis	exocytosis	NN
cord-258536-qnn9hp8e	38	8	(	(	-LRB-
cord-258536-qnn9hp8e	38	9	step	step	NN
cord-258536-qnn9hp8e	38	10	10	10	CD
cord-258536-qnn9hp8e	38	11	)	)	-RRB-
cord-258536-qnn9hp8e	38	12	.	.	.
cord-258536-qnn9hp8e	39	1	Within	within	IN
cord-258536-qnn9hp8e	39	2	the	the	DT
cord-258536-qnn9hp8e	39	3	term	term	NN
cord-258536-qnn9hp8e	39	4	autophagy	autophagy	NN
cord-258536-qnn9hp8e	39	5	are	be	VBP
cord-258536-qnn9hp8e	39	6	grouped	group	VBN
cord-258536-qnn9hp8e	39	7	all	all	PDT
cord-258536-qnn9hp8e	39	8	those	those	DT
cord-258536-qnn9hp8e	39	9	catabolic	catabolic	JJ
cord-258536-qnn9hp8e	39	10	pathways	pathway	NNS
cord-258536-qnn9hp8e	39	11	mediating	mediate	VBG
cord-258536-qnn9hp8e	39	12	the	the	DT
cord-258536-qnn9hp8e	39	13	delivery	delivery	NN
cord-258536-qnn9hp8e	39	14	of	of	IN
cord-258536-qnn9hp8e	39	15	cytoplasmic	cytoplasmic	JJ
cord-258536-qnn9hp8e	39	16	material	material	NN
cord-258536-qnn9hp8e	39	17	into	into	IN
cord-258536-qnn9hp8e	39	18	the	the	DT
cord-258536-qnn9hp8e	39	19	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	39	20	or	or	CC
cord-258536-qnn9hp8e	39	21	plant	plant	NN
cord-258536-qnn9hp8e	39	22	/	/	SYM
cord-258536-qnn9hp8e	39	23	yeast	yeast	NN
cord-258536-qnn9hp8e	39	24	vacuole	vacuole	NN
cord-258536-qnn9hp8e	39	25	for	for	IN
cord-258536-qnn9hp8e	39	26	degradation	degradation	NN
cord-258536-qnn9hp8e	39	27	.	.	.
cord-258536-qnn9hp8e	40	1	There	there	EX
cord-258536-qnn9hp8e	40	2	are	be	VBP
cord-258536-qnn9hp8e	40	3	three	three	CD
cord-258536-qnn9hp8e	40	4	major	major	JJ
cord-258536-qnn9hp8e	40	5	types	type	NNS
cord-258536-qnn9hp8e	40	6	of	of	IN
cord-258536-qnn9hp8e	40	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	40	8	,	,	,
cord-258536-qnn9hp8e	40	9	i.e.	i.e.	FW
cord-258536-qnn9hp8e	40	10	,	,	,
cord-258536-qnn9hp8e	40	11	macroautophagy	macroautophagy	NN
cord-258536-qnn9hp8e	40	12	,	,	,
cord-258536-qnn9hp8e	40	13	microautophagy	microautophagy	NN
cord-258536-qnn9hp8e	40	14	,	,	,
cord-258536-qnn9hp8e	40	15	and	and	CC
cord-258536-qnn9hp8e	40	16	chaperone	chaperone	NN
cord-258536-qnn9hp8e	40	17	-	-	HYPH
cord-258536-qnn9hp8e	40	18	mediated	mediate	VBN
cord-258536-qnn9hp8e	40	19	autophagy	autophagy	NN
cord-258536-qnn9hp8e	40	20	[	[	-LRB-
cord-258536-qnn9hp8e	40	21	26	26	CD
cord-258536-qnn9hp8e	40	22	]	]	-RRB-
cord-258536-qnn9hp8e	40	23	.	.	.
cord-258536-qnn9hp8e	41	1	Macroautophagy	Macroautophagy	NNP
cord-258536-qnn9hp8e	41	2	(	(	-LRB-
cord-258536-qnn9hp8e	41	3	hereafter	hereafter	RB
cord-258536-qnn9hp8e	41	4	referred	refer	VBN
cord-258536-qnn9hp8e	41	5	to	to	IN
cord-258536-qnn9hp8e	41	6	as	as	IN
cord-258536-qnn9hp8e	41	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	41	8	)	)	-RRB-
cord-258536-qnn9hp8e	41	9	is	be	VBZ
cord-258536-qnn9hp8e	41	10	conserved	conserve	VBN
cord-258536-qnn9hp8e	41	11	among	among	IN
cord-258536-qnn9hp8e	41	12	eukaryotes	eukaryote	NNS
cord-258536-qnn9hp8e	41	13	that	that	WDT
cord-258536-qnn9hp8e	41	14	allows	allow	VBZ
cord-258536-qnn9hp8e	41	15	the	the	DT
cord-258536-qnn9hp8e	41	16	turnover	turnover	NN
cord-258536-qnn9hp8e	41	17	of	of	IN
cord-258536-qnn9hp8e	41	18	excess	excess	JJ
cord-258536-qnn9hp8e	41	19	or	or	CC
cord-258536-qnn9hp8e	41	20	damaged	damage	VBN
cord-258536-qnn9hp8e	41	21	cellular	cellular	JJ
cord-258536-qnn9hp8e	41	22	components	component	NNS
cord-258536-qnn9hp8e	41	23	,	,	,
cord-258536-qnn9hp8e	41	24	including	include	VBG
cord-258536-qnn9hp8e	41	25	long	long	RB
cord-258536-qnn9hp8e	41	26	-	-	HYPH
cord-258536-qnn9hp8e	41	27	lived	live	VBN
cord-258536-qnn9hp8e	41	28	Arteriviruses	Arteriviruses	NNPS
cord-258536-qnn9hp8e	41	29	and	and	CC
cord-258536-qnn9hp8e	41	30	Coronaviruses	Coronaviruses	NNP
cord-258536-qnn9hp8e	41	31	.	.	.
cord-258536-qnn9hp8e	42	1	Infection	infection	NN
cord-258536-qnn9hp8e	42	2	starts	start	VBZ
cord-258536-qnn9hp8e	42	3	with	with	IN
cord-258536-qnn9hp8e	42	4	the	the	DT
cord-258536-qnn9hp8e	42	5	binding	binding	NN
cord-258536-qnn9hp8e	42	6	of	of	IN
cord-258536-qnn9hp8e	42	7	the	the	DT
cord-258536-qnn9hp8e	42	8	viral	viral	JJ
cord-258536-qnn9hp8e	42	9	particle	particle	NN
cord-258536-qnn9hp8e	42	10	to	to	IN
cord-258536-qnn9hp8e	42	11	a	a	DT
cord-258536-qnn9hp8e	42	12	cell	cell	NN
cord-258536-qnn9hp8e	42	13	surface	surface	NN
cord-258536-qnn9hp8e	42	14	receptor	receptor	NN
cord-258536-qnn9hp8e	42	15	and	and	CC
cord-258536-qnn9hp8e	42	16	subsequent	subsequent	JJ
cord-258536-qnn9hp8e	42	17	cell	cell	NN
cord-258536-qnn9hp8e	42	18	entry	entry	NN
cord-258536-qnn9hp8e	42	19	through	through	IN
cord-258536-qnn9hp8e	42	20	membrane	membrane	NN
cord-258536-qnn9hp8e	42	21	fusion	fusion	NN
cord-258536-qnn9hp8e	42	22	in	in	IN
cord-258536-qnn9hp8e	42	23	endosomes	endosome	NNS
cord-258536-qnn9hp8e	42	24	upon	upon	IN
cord-258536-qnn9hp8e	42	25	endocytosis	endocytosis	NN
cord-258536-qnn9hp8e	42	26	(	(	-LRB-
cord-258536-qnn9hp8e	42	27	step	step	NN
cord-258536-qnn9hp8e	42	28	1	1	CD
cord-258536-qnn9hp8e	42	29	)	)	-RRB-
cord-258536-qnn9hp8e	42	30	.	.	.
cord-258536-qnn9hp8e	43	1	Translation	translation	NN
cord-258536-qnn9hp8e	43	2	of	of	IN
cord-258536-qnn9hp8e	43	3	the	the	DT
cord-258536-qnn9hp8e	43	4	released	release	VBN
cord-258536-qnn9hp8e	43	5	genomic	genomic	JJ
cord-258536-qnn9hp8e	43	6	RNA	RNA	NNP
cord-258536-qnn9hp8e	43	7	(	(	-LRB-
cord-258536-qnn9hp8e	43	8	gRNA	gRNA	NNP
cord-258536-qnn9hp8e	43	9	)	)	-RRB-
cord-258536-qnn9hp8e	43	10	yields	yield	VBZ
cord-258536-qnn9hp8e	43	11	replicase	replicase	NNP
cord-258536-qnn9hp8e	43	12	polyproteins	polyproteins	NNP
cord-258536-qnn9hp8e	43	13	(	(	-LRB-
cord-258536-qnn9hp8e	43	14	step	step	NNP
cord-258536-qnn9hp8e	43	15	2	2	CD
cord-258536-qnn9hp8e	43	16	)	)	-RRB-
cord-258536-qnn9hp8e	43	17	,	,	,
cord-258536-qnn9hp8e	43	18	i.e.	i.e.	FW
cord-258536-qnn9hp8e	43	19	,	,	,
cord-258536-qnn9hp8e	43	20	polyprotein	polyprotein	NNP
cord-258536-qnn9hp8e	43	21	1a	1a	CD
cord-258536-qnn9hp8e	43	22	(	(	-LRB-
cord-258536-qnn9hp8e	43	23	pp1a	pp1a	NNP
cord-258536-qnn9hp8e	43	24	)	)	-RRB-
cord-258536-qnn9hp8e	43	25	and	and	CC
cord-258536-qnn9hp8e	43	26	polyprotein	polyprotein	JJ
cord-258536-qnn9hp8e	43	27	1ab	1ab	NNP
cord-258536-qnn9hp8e	43	28	(	(	-LRB-
cord-258536-qnn9hp8e	43	29	pp1ab	pp1ab	NNP
cord-258536-qnn9hp8e	43	30	)	)	-RRB-
cord-258536-qnn9hp8e	43	31	,	,	,
cord-258536-qnn9hp8e	43	32	which	which	WDT
cord-258536-qnn9hp8e	43	33	undergo	undergo	VBP
cord-258536-qnn9hp8e	43	34	autoproteolytic	autoproteolytic	JJ
cord-258536-qnn9hp8e	43	35	processing	processing	NN
cord-258536-qnn9hp8e	43	36	to	to	TO
cord-258536-qnn9hp8e	43	37	generate	generate	VB
cord-258536-qnn9hp8e	43	38	nonstructural	nonstructural	JJ
cord-258536-qnn9hp8e	43	39	proteins	protein	NNS
cord-258536-qnn9hp8e	43	40	that	that	WDT
cord-258536-qnn9hp8e	43	41	assemble	assemble	VBP
cord-258536-qnn9hp8e	43	42	into	into	IN
cord-258536-qnn9hp8e	43	43	replication	replication	NN
cord-258536-qnn9hp8e	43	44	-	-	HYPH
cord-258536-qnn9hp8e	43	45	transcription	transcription	NN
cord-258536-qnn9hp8e	43	46	complexes	complex	NNS
cord-258536-qnn9hp8e	43	47	(	(	-LRB-
cord-258536-qnn9hp8e	43	48	RTCs	RTCs	NNP
cord-258536-qnn9hp8e	43	49	)	)	-RRB-
cord-258536-qnn9hp8e	43	50	.	.	.
cord-258536-qnn9hp8e	44	1	The	the	DT
cord-258536-qnn9hp8e	44	2	RTCs	rtc	NNS
cord-258536-qnn9hp8e	44	3	are	be	VBP
cord-258536-qnn9hp8e	44	4	part	part	NN
cord-258536-qnn9hp8e	44	5	of	of	IN
cord-258536-qnn9hp8e	44	6	a	a	DT
cord-258536-qnn9hp8e	44	7	complex	complex	JJ
cord-258536-qnn9hp8e	44	8	membranous	membranous	JJ
cord-258536-qnn9hp8e	44	9	network	network	NN
cord-258536-qnn9hp8e	44	10	composed	compose	VBN
cord-258536-qnn9hp8e	44	11	of	of	IN
cord-258536-qnn9hp8e	44	12	double	double	JJ
cord-258536-qnn9hp8e	44	13	membrane	membrane	NN
cord-258536-qnn9hp8e	44	14	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	44	15	(	(	-LRB-
cord-258536-qnn9hp8e	44	16	DMVs	dmv	NNS
cord-258536-qnn9hp8e	44	17	)	)	-RRB-
cord-258536-qnn9hp8e	44	18	and	and	CC
cord-258536-qnn9hp8e	44	19	convoluted	convoluted	JJ
cord-258536-qnn9hp8e	44	20	membranes	membrane	NNS
cord-258536-qnn9hp8e	44	21	(	(	-LRB-
cord-258536-qnn9hp8e	44	22	step	step	NN
cord-258536-qnn9hp8e	44	23	4	4	CD
cord-258536-qnn9hp8e	44	24	)	)	-RRB-
cord-258536-qnn9hp8e	44	25	.	.	.
cord-258536-qnn9hp8e	45	1	The	the	DT
cord-258536-qnn9hp8e	45	2	RTCs	rtc	NNS
cord-258536-qnn9hp8e	45	3	first	first	RB
cord-258536-qnn9hp8e	45	4	engage	engage	VBP
cord-258536-qnn9hp8e	45	5	in	in	IN
cord-258536-qnn9hp8e	45	6	minus	minus	JJ
cord-258536-qnn9hp8e	45	7	-	-	HYPH
cord-258536-qnn9hp8e	45	8	strand	strand	NN
cord-258536-qnn9hp8e	45	9	RNA	RNA	NNP
cord-258536-qnn9hp8e	45	10	synthesis	synthesis	NN
cord-258536-qnn9hp8e	45	11	to	to	TO
cord-258536-qnn9hp8e	45	12	produce	produce	VB
cord-258536-qnn9hp8e	45	13	both	both	DT
cord-258536-qnn9hp8e	45	14	single	single	JJ
cord-258536-qnn9hp8e	45	15	strand	strand	NN
cord-258536-qnn9hp8e	45	16	full	full	JJ
cord-258536-qnn9hp8e	45	17	-	-	HYPH
cord-258536-qnn9hp8e	45	18	length	length	NN
cord-258536-qnn9hp8e	45	19	and	and	CC
cord-258536-qnn9hp8e	45	20	subgenomic	subgenomic	NNP
cord-258536-qnn9hp8e	45	21	(	(	-LRB-
cord-258536-qnn9hp8e	45	22	sg	sg	NNP
cord-258536-qnn9hp8e	45	23	)	)	-RRB-
cord-258536-qnn9hp8e	45	24	minus	minus	JJ
cord-258536-qnn9hp8e	45	25	-	-	HYPH
cord-258536-qnn9hp8e	45	26	strand	strand	NN
cord-258536-qnn9hp8e	45	27	RNAs	rna	NNS
cord-258536-qnn9hp8e	45	28	(	(	-LRB-
cord-258536-qnn9hp8e	45	29	step	step	NN
cord-258536-qnn9hp8e	45	30	5	5	CD
cord-258536-qnn9hp8e	45	31	)	)	-RRB-
cord-258536-qnn9hp8e	45	32	.	.	.
cord-258536-qnn9hp8e	46	1	Subsequently	subsequently	RB
cord-258536-qnn9hp8e	46	2	,	,	,
cord-258536-qnn9hp8e	46	3	they	-PRON-	PRP
cord-258536-qnn9hp8e	46	4	use	use	VBP
cord-258536-qnn9hp8e	46	5	sg	sg	NNP
cord-258536-qnn9hp8e	46	6	mRNAs	mRNAs	NNP
cord-258536-qnn9hp8e	46	7	as	as	IN
cord-258536-qnn9hp8e	46	8	templates	template	NNS
cord-258536-qnn9hp8e	46	9	for	for	IN
cord-258536-qnn9hp8e	46	10	the	the	DT
cord-258536-qnn9hp8e	46	11	production	production	NN
cord-258536-qnn9hp8e	46	12	of	of	IN
cord-258536-qnn9hp8e	46	13	the	the	DT
cord-258536-qnn9hp8e	46	14	gRNA	gRNA	NNS
cord-258536-qnn9hp8e	46	15	and	and	CC
cord-258536-qnn9hp8e	46	16	plus	plus	JJ
cord-258536-qnn9hp8e	46	17	-	-	HYPH
cord-258536-qnn9hp8e	46	18	strand	strand	NN
cord-258536-qnn9hp8e	46	19	sg	sg	NNP
cord-258536-qnn9hp8e	46	20	mRNAs	mRNAs	NNP
cord-258536-qnn9hp8e	46	21	required	require	VBD
cord-258536-qnn9hp8e	46	22	to	to	TO
cord-258536-qnn9hp8e	46	23	express	express	VB
cord-258536-qnn9hp8e	46	24	the	the	DT
cord-258536-qnn9hp8e	46	25	structural	structural	JJ
cord-258536-qnn9hp8e	46	26	protein	protein	NN
cord-258536-qnn9hp8e	46	27	genes	gene	NNS
cord-258536-qnn9hp8e	46	28	(	(	-LRB-
cord-258536-qnn9hp8e	46	29	step	step	NNP
cord-258536-qnn9hp8e	46	30	6	6	CD
cord-258536-qnn9hp8e	46	31	)	)	-RRB-
cord-258536-qnn9hp8e	46	32	.	.	.
cord-258536-qnn9hp8e	47	1	Newly	newly	RB
cord-258536-qnn9hp8e	47	2	synthesized	synthesize	VBN
cord-258536-qnn9hp8e	47	3	S	S	NNP
cord-258536-qnn9hp8e	47	4	,	,	,
cord-258536-qnn9hp8e	47	5	E	E	NNP
cord-258536-qnn9hp8e	47	6	,	,	,
cord-258536-qnn9hp8e	47	7	and	and	CC
cord-258536-qnn9hp8e	47	8	M	M	NNP
cord-258536-qnn9hp8e	47	9	structural	structural	JJ
cord-258536-qnn9hp8e	47	10	proteins	protein	NNS
cord-258536-qnn9hp8e	47	11	are	be	VBP
cord-258536-qnn9hp8e	47	12	inserted	insert	VBN
cord-258536-qnn9hp8e	47	13	in	in	IN
cord-258536-qnn9hp8e	47	14	the	the	DT
cord-258536-qnn9hp8e	47	15	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	47	16	reticulum	reticulum	NN
cord-258536-qnn9hp8e	47	17	(	(	-LRB-
cord-258536-qnn9hp8e	47	18	ER	ER	NNP
cord-258536-qnn9hp8e	47	19	)	)	-RRB-
cord-258536-qnn9hp8e	47	20	(	(	-LRB-
cord-258536-qnn9hp8e	47	21	steps	step	VBZ
cord-258536-qnn9hp8e	47	22	7	7	CD
cord-258536-qnn9hp8e	47	23	and	and	CC
cord-258536-qnn9hp8e	47	24	8)	8)	NN
cord-258536-qnn9hp8e	47	25	,	,	,
cord-258536-qnn9hp8e	47	26	whereas	whereas	IN
cord-258536-qnn9hp8e	47	27	the	the	DT
cord-258536-qnn9hp8e	47	28	N	n	CD
cord-258536-qnn9hp8e	47	29	nucleocapsides	nucleocapside	NNS
cord-258536-qnn9hp8e	47	30	are	be	VBP
cord-258536-qnn9hp8e	47	31	translated	translate	VBN
cord-258536-qnn9hp8e	47	32	and	and	CC
cord-258536-qnn9hp8e	47	33	oligomerize	oligomerize	NN
cord-258536-qnn9hp8e	47	34	in	in	IN
cord-258536-qnn9hp8e	47	35	the	the	DT
cord-258536-qnn9hp8e	47	36	cytosol	cytosol	NN
cord-258536-qnn9hp8e	47	37	,	,	,
cord-258536-qnn9hp8e	47	38	where	where	WRB
cord-258536-qnn9hp8e	47	39	they	-PRON-	PRP
cord-258536-qnn9hp8e	47	40	interact	interact	VBP
cord-258536-qnn9hp8e	47	41	with	with	IN
cord-258536-qnn9hp8e	47	42	RTCs	rtc	NNS
cord-258536-qnn9hp8e	47	43	and	and	CC
cord-258536-qnn9hp8e	47	44	associate	associate	VB
cord-258536-qnn9hp8e	47	45	with	with	IN
cord-258536-qnn9hp8e	47	46	the	the	DT
cord-258536-qnn9hp8e	47	47	gRNA	gRNA	NNS
cord-258536-qnn9hp8e	47	48	to	to	TO
cord-258536-qnn9hp8e	47	49	form	form	VB
cord-258536-qnn9hp8e	47	50	the	the	DT
cord-258536-qnn9hp8e	47	51	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	47	52	complexes	complex	NNS
cord-258536-qnn9hp8e	47	53	(	(	-LRB-
cord-258536-qnn9hp8e	47	54	step	step	NNP
cord-258536-qnn9hp8e	47	55	7	7	CD
cord-258536-qnn9hp8e	47	56	)	)	-RRB-
cord-258536-qnn9hp8e	47	57	.	.	.
cord-258536-qnn9hp8e	48	1	Virion	virion	NN
cord-258536-qnn9hp8e	48	2	assembly	assembly	NN
cord-258536-qnn9hp8e	48	3	takes	take	VBZ
cord-258536-qnn9hp8e	48	4	place	place	NN
cord-258536-qnn9hp8e	48	5	in	in	IN
cord-258536-qnn9hp8e	48	6	the	the	DT
cord-258536-qnn9hp8e	48	7	ER	ER	NNP
cord-258536-qnn9hp8e	48	8	and/or	and/or	CC
cord-258536-qnn9hp8e	48	9	Golgi	Golgi	NNP
cord-258536-qnn9hp8e	48	10	(	(	-LRB-
cord-258536-qnn9hp8e	48	11	step	step	NN
cord-258536-qnn9hp8e	48	12	9	9	CD
cord-258536-qnn9hp8e	48	13	)	)	-RRB-
cord-258536-qnn9hp8e	48	14	,	,	,
cord-258536-qnn9hp8e	48	15	and	and	CC
cord-258536-qnn9hp8e	48	16	involves	involve	VBZ
cord-258536-qnn9hp8e	48	17	the	the	DT
cord-258536-qnn9hp8e	48	18	inward	inward	JJ
cord-258536-qnn9hp8e	48	19	budding	budding	NN
cord-258536-qnn9hp8e	48	20	of	of	IN
cord-258536-qnn9hp8e	48	21	the	the	DT
cord-258536-qnn9hp8e	48	22	limiting	limit	VBG
cord-258536-qnn9hp8e	48	23	membrane	membrane	NN
cord-258536-qnn9hp8e	48	24	of	of	IN
cord-258536-qnn9hp8e	48	25	these	these	DT
cord-258536-qnn9hp8e	48	26	compartments	compartment	NNS
cord-258536-qnn9hp8e	48	27	,	,	,
cord-258536-qnn9hp8e	48	28	which	which	WDT
cord-258536-qnn9hp8e	48	29	is	be	VBZ
cord-258536-qnn9hp8e	48	30	triggered	trigger	VBN
cord-258536-qnn9hp8e	48	31	by	by	IN
cord-258536-qnn9hp8e	48	32	the	the	DT
cord-258536-qnn9hp8e	48	33	interaction	interaction	NN
cord-258536-qnn9hp8e	48	34	between	between	IN
cord-258536-qnn9hp8e	48	35	the	the	DT
cord-258536-qnn9hp8e	48	36	structural	structural	JJ
cord-258536-qnn9hp8e	48	37	proteins	protein	NNS
cord-258536-qnn9hp8e	48	38	and	and	CC
cord-258536-qnn9hp8e	48	39	the	the	DT
cord-258536-qnn9hp8e	48	40	ribonucleoprotein	ribonucleoprotein	NN
cord-258536-qnn9hp8e	48	41	complexes	complex	NNS
cord-258536-qnn9hp8e	48	42	.	.	.
cord-258536-qnn9hp8e	49	1	Mature	mature	JJ
cord-258536-qnn9hp8e	49	2	virions	virion	NNS
cord-258536-qnn9hp8e	49	3	are	be	VBP
cord-258536-qnn9hp8e	49	4	released	release	VBN
cord-258536-qnn9hp8e	49	5	extracellularly	extracellularly	RB
cord-258536-qnn9hp8e	49	6	by	by	IN
cord-258536-qnn9hp8e	49	7	exocytosis	exocytosis	NN
cord-258536-qnn9hp8e	49	8	(	(	-LRB-
cord-258536-qnn9hp8e	49	9	step	step	NN
cord-258536-qnn9hp8e	49	10	10	10	CD
cord-258536-qnn9hp8e	49	11	)	)	-RRB-
cord-258536-qnn9hp8e	49	12	.	.	.
cord-258536-qnn9hp8e	50	1	Within	within	IN
cord-258536-qnn9hp8e	50	2	the	the	DT
cord-258536-qnn9hp8e	50	3	term	term	NN
cord-258536-qnn9hp8e	50	4	autophagy	autophagy	NN
cord-258536-qnn9hp8e	50	5	are	be	VBP
cord-258536-qnn9hp8e	50	6	grouped	group	VBN
cord-258536-qnn9hp8e	50	7	all	all	PDT
cord-258536-qnn9hp8e	50	8	those	those	DT
cord-258536-qnn9hp8e	50	9	catabolic	catabolic	JJ
cord-258536-qnn9hp8e	50	10	pathways	pathway	NNS
cord-258536-qnn9hp8e	50	11	mediating	mediate	VBG
cord-258536-qnn9hp8e	50	12	the	the	DT
cord-258536-qnn9hp8e	50	13	delivery	delivery	NN
cord-258536-qnn9hp8e	50	14	of	of	IN
cord-258536-qnn9hp8e	50	15	cytoplasmic	cytoplasmic	JJ
cord-258536-qnn9hp8e	50	16	material	material	NN
cord-258536-qnn9hp8e	50	17	into	into	IN
cord-258536-qnn9hp8e	50	18	the	the	DT
cord-258536-qnn9hp8e	50	19	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	50	20	or	or	CC
cord-258536-qnn9hp8e	50	21	plant	plant	NN
cord-258536-qnn9hp8e	50	22	/	/	SYM
cord-258536-qnn9hp8e	50	23	yeast	yeast	NN
cord-258536-qnn9hp8e	50	24	vacuole	vacuole	NN
cord-258536-qnn9hp8e	50	25	for	for	IN
cord-258536-qnn9hp8e	50	26	degradation	degradation	NN
cord-258536-qnn9hp8e	50	27	.	.	.
cord-258536-qnn9hp8e	51	1	There	there	EX
cord-258536-qnn9hp8e	51	2	are	be	VBP
cord-258536-qnn9hp8e	51	3	three	three	CD
cord-258536-qnn9hp8e	51	4	major	major	JJ
cord-258536-qnn9hp8e	51	5	types	type	NNS
cord-258536-qnn9hp8e	51	6	of	of	IN
cord-258536-qnn9hp8e	51	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	51	8	,	,	,
cord-258536-qnn9hp8e	51	9	i.e.	i.e.	FW
cord-258536-qnn9hp8e	51	10	,	,	,
cord-258536-qnn9hp8e	51	11	macroautophagy	macroautophagy	NN
cord-258536-qnn9hp8e	51	12	,	,	,
cord-258536-qnn9hp8e	51	13	microautophagy	microautophagy	NN
cord-258536-qnn9hp8e	51	14	,	,	,
cord-258536-qnn9hp8e	51	15	and	and	CC
cord-258536-qnn9hp8e	51	16	chaperone	chaperone	NN
cord-258536-qnn9hp8e	51	17	-	-	HYPH
cord-258536-qnn9hp8e	51	18	mediated	mediate	VBN
cord-258536-qnn9hp8e	51	19	autophagy	autophagy	NN
cord-258536-qnn9hp8e	51	20	[	[	-LRB-
cord-258536-qnn9hp8e	51	21	26	26	CD
cord-258536-qnn9hp8e	51	22	]	]	-RRB-
cord-258536-qnn9hp8e	51	23	.	.	.
cord-258536-qnn9hp8e	52	1	Macroautophagy	Macroautophagy	NNP
cord-258536-qnn9hp8e	52	2	(	(	-LRB-
cord-258536-qnn9hp8e	52	3	hereafter	hereafter	RB
cord-258536-qnn9hp8e	52	4	referred	refer	VBN
cord-258536-qnn9hp8e	52	5	to	to	IN
cord-258536-qnn9hp8e	52	6	as	as	IN
cord-258536-qnn9hp8e	52	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	52	8	)	)	-RRB-
cord-258536-qnn9hp8e	52	9	is	be	VBZ
cord-258536-qnn9hp8e	52	10	conserved	conserve	VBN
cord-258536-qnn9hp8e	52	11	among	among	IN
cord-258536-qnn9hp8e	52	12	eukaryotes	eukaryote	NNS
cord-258536-qnn9hp8e	52	13	that	that	WDT
cord-258536-qnn9hp8e	52	14	allows	allow	VBZ
cord-258536-qnn9hp8e	52	15	the	the	DT
cord-258536-qnn9hp8e	52	16	turnover	turnover	NN
cord-258536-qnn9hp8e	52	17	of	of	IN
cord-258536-qnn9hp8e	52	18	excess	excess	JJ
cord-258536-qnn9hp8e	52	19	or	or	CC
cord-258536-qnn9hp8e	52	20	damaged	damage	VBN
cord-258536-qnn9hp8e	52	21	cellular	cellular	JJ
cord-258536-qnn9hp8e	52	22	components	component	NNS
cord-258536-qnn9hp8e	52	23	,	,	,
cord-258536-qnn9hp8e	52	24	including	include	VBG
cord-258536-qnn9hp8e	52	25	long	long	RB
cord-258536-qnn9hp8e	52	26	-	-	HYPH
cord-258536-qnn9hp8e	52	27	lived	live	VBN
cord-258536-qnn9hp8e	52	28	proteins	protein	NNS
cord-258536-qnn9hp8e	52	29	and	and	CC
cord-258536-qnn9hp8e	52	30	organelles	organelle	NNS
cord-258536-qnn9hp8e	52	31	,	,	,
cord-258536-qnn9hp8e	52	32	to	to	TO
cord-258536-qnn9hp8e	52	33	maintain	maintain	VB
cord-258536-qnn9hp8e	52	34	cellular	cellular	JJ
cord-258536-qnn9hp8e	52	35	energy	energy	NN
cord-258536-qnn9hp8e	52	36	levels	level	NNS
cord-258536-qnn9hp8e	52	37	and	and	CC
cord-258536-qnn9hp8e	52	38	ensure	ensure	VB
cord-258536-qnn9hp8e	52	39	survival	survival	NN
cord-258536-qnn9hp8e	52	40	[	[	-LRB-
cord-258536-qnn9hp8e	52	41	27	27	CD
cord-258536-qnn9hp8e	52	42	]	]	-RRB-
cord-258536-qnn9hp8e	53	1	[	[	-LRB-
cord-258536-qnn9hp8e	53	2	28	28	CD
cord-258536-qnn9hp8e	53	3	]	]	-RRB-
cord-258536-qnn9hp8e	53	4	[	[	-LRB-
cord-258536-qnn9hp8e	53	5	29	29	CD
cord-258536-qnn9hp8e	53	6	]	]	-RRB-
cord-258536-qnn9hp8e	53	7	[	[	-LRB-
cord-258536-qnn9hp8e	53	8	30	30	CD
cord-258536-qnn9hp8e	53	9	]	]	-RRB-
cord-258536-qnn9hp8e	53	10	[	[	-LRB-
cord-258536-qnn9hp8e	53	11	31	31	CD
cord-258536-qnn9hp8e	53	12	]	]	-RRB-
cord-258536-qnn9hp8e	53	13	[	[	-LRB-
cord-258536-qnn9hp8e	53	14	32	32	CD
cord-258536-qnn9hp8e	53	15	]	]	-RRB-
cord-258536-qnn9hp8e	53	16	[	[	-LRB-
cord-258536-qnn9hp8e	53	17	33	33	CD
cord-258536-qnn9hp8e	53	18	]	]	-RRB-
cord-258536-qnn9hp8e	53	19	[	[	-LRB-
cord-258536-qnn9hp8e	53	20	34	34	CD
cord-258536-qnn9hp8e	53	21	]	]	-RRB-
cord-258536-qnn9hp8e	53	22	[	[	-LRB-
cord-258536-qnn9hp8e	53	23	35	35	CD
cord-258536-qnn9hp8e	53	24	]	]	-RRB-
cord-258536-qnn9hp8e	53	25	.	.	.
cord-258536-qnn9hp8e	54	1	This	this	DT
cord-258536-qnn9hp8e	54	2	process	process	NN
cord-258536-qnn9hp8e	54	3	is	be	VBZ
cord-258536-qnn9hp8e	54	4	characterized	characterize	VBN
cord-258536-qnn9hp8e	54	5	by	by	IN
cord-258536-qnn9hp8e	54	6	double	double	JJ
cord-258536-qnn9hp8e	54	7	-	-	HYPH
cord-258536-qnn9hp8e	54	8	membrane	membrane	NN
cord-258536-qnn9hp8e	54	9	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	54	10	called	call	VBN
cord-258536-qnn9hp8e	54	11	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	54	12	,	,	,
cord-258536-qnn9hp8e	54	13	which	which	WDT
cord-258536-qnn9hp8e	54	14	sequester	sequester	VBP
cord-258536-qnn9hp8e	54	15	the	the	DT
cord-258536-qnn9hp8e	54	16	cytoplasmic	cytoplasmic	JJ
cord-258536-qnn9hp8e	54	17	components	component	NNS
cord-258536-qnn9hp8e	54	18	targeted	target	VBN
cord-258536-qnn9hp8e	54	19	to	to	IN
cord-258536-qnn9hp8e	54	20	destruction	destruction	NN
cord-258536-qnn9hp8e	54	21	and	and	CC
cord-258536-qnn9hp8e	54	22	deliver	deliver	VB
cord-258536-qnn9hp8e	54	23	them	-PRON-	PRP
cord-258536-qnn9hp8e	54	24	into	into	IN
cord-258536-qnn9hp8e	54	25	lysosomes	lysosome	NNS
cord-258536-qnn9hp8e	54	26	for	for	IN
cord-258536-qnn9hp8e	54	27	degradation	degradation	NN
cord-258536-qnn9hp8e	54	28	[	[	-LRB-
cord-258536-qnn9hp8e	54	29	33	33	CD
cord-258536-qnn9hp8e	54	30	]	]	-RRB-
cord-258536-qnn9hp8e	54	31	[	[	-LRB-
cord-258536-qnn9hp8e	54	32	34	34	CD
cord-258536-qnn9hp8e	54	33	]	]	-RRB-
cord-258536-qnn9hp8e	54	34	[	[	-LRB-
cord-258536-qnn9hp8e	54	35	35	35	CD
cord-258536-qnn9hp8e	54	36	]	]	-RRB-
cord-258536-qnn9hp8e	54	37	[	[	-LRB-
cord-258536-qnn9hp8e	54	38	36	36	CD
cord-258536-qnn9hp8e	54	39	]	]	-RRB-
cord-258536-qnn9hp8e	55	1	[	[	-LRB-
cord-258536-qnn9hp8e	55	2	37	37	CD
cord-258536-qnn9hp8e	55	3	]	]	-RRB-
cord-258536-qnn9hp8e	55	4	(	(	-LRB-
cord-258536-qnn9hp8e	55	5	Figure	figure	NN
cord-258536-qnn9hp8e	55	6	3	3	CD
cord-258536-qnn9hp8e	55	7	)	)	-RRB-
cord-258536-qnn9hp8e	55	8	.	.	.
cord-258536-qnn9hp8e	56	1	The	the	DT
cord-258536-qnn9hp8e	56	2	process	process	NN
cord-258536-qnn9hp8e	56	3	can	can	MD
cord-258536-qnn9hp8e	56	4	be	be	VB
cord-258536-qnn9hp8e	56	5	divided	divide	VBN
cord-258536-qnn9hp8e	56	6	into	into	IN
cord-258536-qnn9hp8e	56	7	three	three	CD
cord-258536-qnn9hp8e	56	8	different	different	JJ
cord-258536-qnn9hp8e	56	9	steps	step	NNS
cord-258536-qnn9hp8e	56	10	:	:	:
cord-258536-qnn9hp8e	56	11	The	the	DT
cord-258536-qnn9hp8e	56	12	initiation	initiation	NN
cord-258536-qnn9hp8e	56	13	step	step	NN
cord-258536-qnn9hp8e	56	14	,	,	,
cord-258536-qnn9hp8e	56	15	when	when	WRB
cord-258536-qnn9hp8e	56	16	the	the	DT
cord-258536-qnn9hp8e	56	17	phagophore	phagophore	NN
cord-258536-qnn9hp8e	56	18	or	or	CC
cord-258536-qnn9hp8e	56	19	isolation	isolation	NN
cord-258536-qnn9hp8e	56	20	membrane	membrane	NN
cord-258536-qnn9hp8e	56	21	is	be	VBZ
cord-258536-qnn9hp8e	56	22	formed	form	VBN
cord-258536-qnn9hp8e	56	23	,	,	,
cord-258536-qnn9hp8e	56	24	the	the	DT
cord-258536-qnn9hp8e	56	25	elongation	elongation	NN
cord-258536-qnn9hp8e	56	26	step	step	NN
cord-258536-qnn9hp8e	56	27	,	,	,
cord-258536-qnn9hp8e	56	28	during	during	IN
cord-258536-qnn9hp8e	56	29	which	which	WDT
cord-258536-qnn9hp8e	56	30	the	the	DT
cord-258536-qnn9hp8e	56	31	phagophore	phagophore	NN
cord-258536-qnn9hp8e	56	32	expands	expand	VBZ
cord-258536-qnn9hp8e	56	33	and	and	CC
cord-258536-qnn9hp8e	56	34	close	close	JJ
cord-258536-qnn9hp8e	56	35	to	to	TO
cord-258536-qnn9hp8e	56	36	generate	generate	VB
cord-258536-qnn9hp8e	56	37	an	an	DT
cord-258536-qnn9hp8e	56	38	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	56	39	,	,	,
cord-258536-qnn9hp8e	56	40	and	and	CC
cord-258536-qnn9hp8e	56	41	the	the	DT
cord-258536-qnn9hp8e	56	42	maturation	maturation	NN
cord-258536-qnn9hp8e	56	43	step	step	NN
cord-258536-qnn9hp8e	56	44	,	,	,
cord-258536-qnn9hp8e	56	45	where	where	WRB
cord-258536-qnn9hp8e	56	46	the	the	DT
cord-258536-qnn9hp8e	56	47	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	56	48	fuses	fuse	VBZ
cord-258536-qnn9hp8e	56	49	with	with	IN
cord-258536-qnn9hp8e	56	50	the	the	DT
cord-258536-qnn9hp8e	56	51	lysosome	lysosome	NN
cord-258536-qnn9hp8e	56	52	(	(	-LRB-
cord-258536-qnn9hp8e	56	53	Figure	figure	NN
cord-258536-qnn9hp8e	56	54	3	3	CD
cord-258536-qnn9hp8e	56	55	)	)	-RRB-
cord-258536-qnn9hp8e	56	56	.	.	.
cord-258536-qnn9hp8e	57	1	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	57	2	is	be	VBZ
cord-258536-qnn9hp8e	57	3	regulated	regulate	VBN
cord-258536-qnn9hp8e	57	4	by	by	IN
cord-258536-qnn9hp8e	57	5	several	several	JJ
cord-258536-qnn9hp8e	57	6	signaling	signaling	NN
cord-258536-qnn9hp8e	57	7	cascades	cascade	NNS
cord-258536-qnn9hp8e	57	8	,	,	,
cord-258536-qnn9hp8e	57	9	including	include	VBG
cord-258536-qnn9hp8e	57	10	the	the	DT
cord-258536-qnn9hp8e	57	11	one	one	NN
cord-258536-qnn9hp8e	57	12	centered	center	VBN
cord-258536-qnn9hp8e	57	13	on	on	IN
cord-258536-qnn9hp8e	57	14	the	the	DT
cord-258536-qnn9hp8e	57	15	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	57	16	target	target	NN
cord-258536-qnn9hp8e	57	17	of	of	IN
cord-258536-qnn9hp8e	57	18	rapamycin	rapamycin	NNP
cord-258536-qnn9hp8e	57	19	(	(	-LRB-
cord-258536-qnn9hp8e	57	20	mTOR	mTOR	NNP
cord-258536-qnn9hp8e	57	21	)	)	-RRB-
cord-258536-qnn9hp8e	57	22	[	[	-LRB-
cord-258536-qnn9hp8e	57	23	34	34	CD
cord-258536-qnn9hp8e	57	24	,	,	,
cord-258536-qnn9hp8e	57	25	35	35	CD
cord-258536-qnn9hp8e	57	26	,	,	,
cord-258536-qnn9hp8e	57	27	38	38	CD
cord-258536-qnn9hp8e	57	28	]	]	-RRB-
cord-258536-qnn9hp8e	57	29	.	.	.
cord-258536-qnn9hp8e	58	1	Autophagosomes	Autophagosomes	NNP
cord-258536-qnn9hp8e	58	2	are	be	VBP
cord-258536-qnn9hp8e	58	3	formed	form	VBN
cord-258536-qnn9hp8e	58	4	through	through	IN
cord-258536-qnn9hp8e	58	5	the	the	DT
cord-258536-qnn9hp8e	58	6	concerted	concerted	JJ
cord-258536-qnn9hp8e	58	7	action	action	NN
cord-258536-qnn9hp8e	58	8	of	of	IN
cord-258536-qnn9hp8e	58	9	the	the	DT
cord-258536-qnn9hp8e	58	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	58	11	-	-	HYPH
cord-258536-qnn9hp8e	58	12	related	relate	VBN
cord-258536-qnn9hp8e	58	13	(	(	-LRB-
cord-258536-qnn9hp8e	58	14	ATG	ATG	NNP
cord-258536-qnn9hp8e	58	15	)	)	-RRB-
cord-258536-qnn9hp8e	58	16	genes	gene	NNS
cord-258536-qnn9hp8e	58	17	[	[	-LRB-
cord-258536-qnn9hp8e	58	18	29	29	CD
cord-258536-qnn9hp8e	58	19	,	,	,
cord-258536-qnn9hp8e	58	20	33	33	CD
cord-258536-qnn9hp8e	58	21	]	]	-RRB-
cord-258536-qnn9hp8e	58	22	.	.	.
cord-258536-qnn9hp8e	59	1	The	the	DT
cord-258536-qnn9hp8e	59	2	proteins	protein	NNS
cord-258536-qnn9hp8e	59	3	encoded	encode	VBN
cord-258536-qnn9hp8e	59	4	by	by	IN
cord-258536-qnn9hp8e	59	5	the	the	DT
cord-258536-qnn9hp8e	59	6	ATG	ATG	NNP
cord-258536-qnn9hp8e	59	7	genes	gene	NNS
cord-258536-qnn9hp8e	59	8	have	have	VBP
cord-258536-qnn9hp8e	59	9	been	be	VBN
cord-258536-qnn9hp8e	59	10	classified	classify	VBN
cord-258536-qnn9hp8e	59	11	in	in	IN
cord-258536-qnn9hp8e	59	12	five	five	CD
cord-258536-qnn9hp8e	59	13	functional	functional	JJ
cord-258536-qnn9hp8e	59	14	groups	group	NNS
cord-258536-qnn9hp8e	59	15	.	.	.
cord-258536-qnn9hp8e	60	1	The	the	DT
cord-258536-qnn9hp8e	60	2	unc-51	unc-51	JJ
cord-258536-qnn9hp8e	60	3	like	like	IN
cord-258536-qnn9hp8e	60	4	autophagy	autophagy	NN
cord-258536-qnn9hp8e	60	5	activating	activate	VBG
cord-258536-qnn9hp8e	60	6	kinase	kinase	NN
cord-258536-qnn9hp8e	60	7	(	(	-LRB-
cord-258536-qnn9hp8e	60	8	ULK	ULK	NNP
cord-258536-qnn9hp8e	60	9	)	)	-RRB-
cord-258536-qnn9hp8e	61	1	kinase	kinase	NN
cord-258536-qnn9hp8e	61	2	complex	complex	NN
cord-258536-qnn9hp8e	61	3	,	,	,
cord-258536-qnn9hp8e	61	4	the	the	DT
cord-258536-qnn9hp8e	61	5	class	class	NN
cord-258536-qnn9hp8e	61	6	III	iii	CD
cord-258536-qnn9hp8e	61	7	hVPS34	hVPS34	NNP
cord-258536-qnn9hp8e	61	8	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	61	9	3-kinase	3-kinase	CD
cord-258536-qnn9hp8e	61	10	complex	complex	NN
cord-258536-qnn9hp8e	61	11	,	,	,
cord-258536-qnn9hp8e	61	12	and	and	CC
cord-258536-qnn9hp8e	61	13	the	the	DT
cord-258536-qnn9hp8e	61	14	ATG9	ATG9	NNP
cord-258536-qnn9hp8e	61	15	cycling	cycling	NN
cord-258536-qnn9hp8e	61	16	system	system	NN
cord-258536-qnn9hp8e	61	17	,	,	,
cord-258536-qnn9hp8e	61	18	on	on	IN
cord-258536-qnn9hp8e	61	19	one	one	CD
cord-258536-qnn9hp8e	61	20	hand	hand	NN
cord-258536-qnn9hp8e	61	21	,	,	,
cord-258536-qnn9hp8e	61	22	play	play	VB
cord-258536-qnn9hp8e	61	23	a	a	DT
cord-258536-qnn9hp8e	61	24	key	key	JJ
cord-258536-qnn9hp8e	61	25	role	role	NN
cord-258536-qnn9hp8e	61	26	in	in	IN
cord-258536-qnn9hp8e	61	27	the	the	DT
cord-258536-qnn9hp8e	61	28	initiation	initiation	NN
cord-258536-qnn9hp8e	61	29	of	of	IN
cord-258536-qnn9hp8e	61	30	autophagy	autophagy	NN
cord-258536-qnn9hp8e	61	31	and	and	CC
cord-258536-qnn9hp8e	61	32	phagophore	phagophore	NN
cord-258536-qnn9hp8e	61	33	formation	formation	NN
cord-258536-qnn9hp8e	61	34	.	.	.
cord-258536-qnn9hp8e	62	1	The	the	DT
cord-258536-qnn9hp8e	62	2	ATG12	ATG12	NNP
cord-258536-qnn9hp8e	62	3	and	and	CC
cord-258536-qnn9hp8e	62	4	microtubule	microtubule	NN
cord-258536-qnn9hp8e	62	5	-	-	HYPH
cord-258536-qnn9hp8e	62	6	associated	associate	VBN
cord-258536-qnn9hp8e	62	7	protein	protein	NN
cord-258536-qnn9hp8e	62	8	light	light	NN
cord-258536-qnn9hp8e	62	9	chain	chain	NN
cord-258536-qnn9hp8e	62	10	3	3	CD
cord-258536-qnn9hp8e	63	1	(	(	-LRB-
cord-258536-qnn9hp8e	63	2	LC3	LC3	NNP
cord-258536-qnn9hp8e	63	3	)	)	-RRB-
cord-258536-qnn9hp8e	63	4	conjugation	conjugation	NN
cord-258536-qnn9hp8e	63	5	systems	system	NNS
cord-258536-qnn9hp8e	63	6	,	,	,
cord-258536-qnn9hp8e	63	7	on	on	IN
cord-258536-qnn9hp8e	63	8	the	the	DT
cord-258536-qnn9hp8e	63	9	other	other	JJ
cord-258536-qnn9hp8e	63	10	hand	hand	NN
cord-258536-qnn9hp8e	63	11	,	,	,
cord-258536-qnn9hp8e	63	12	mediate	mediate	VB
cord-258536-qnn9hp8e	63	13	the	the	DT
cord-258536-qnn9hp8e	63	14	elongation	elongation	NN
cord-258536-qnn9hp8e	63	15	and	and	CC
cord-258536-qnn9hp8e	63	16	closure	closure	NN
cord-258536-qnn9hp8e	63	17	of	of	IN
cord-258536-qnn9hp8e	63	18	the	the	DT
cord-258536-qnn9hp8e	63	19	phagophore	phagophore	NN
cord-258536-qnn9hp8e	63	20	.	.	.
cord-258536-qnn9hp8e	64	1	The	the	DT
cord-258536-qnn9hp8e	64	2	first	first	JJ
cord-258536-qnn9hp8e	64	3	of	of	IN
cord-258536-qnn9hp8e	64	4	these	these	DT
cord-258536-qnn9hp8e	64	5	ATG	ATG	NNP
cord-258536-qnn9hp8e	64	6	protein	protein	NN
cord-258536-qnn9hp8e	64	7	complexes	complex	NNS
cord-258536-qnn9hp8e	64	8	responds	respond	VBZ
cord-258536-qnn9hp8e	64	9	to	to	TO
cord-258536-qnn9hp8e	64	10	upstream	upstream	VB
cord-258536-qnn9hp8e	64	11	regulatory	regulatory	JJ
cord-258536-qnn9hp8e	64	12	signals	signal	NNS
cord-258536-qnn9hp8e	64	13	,	,	,
cord-258536-qnn9hp8e	64	14	such	such	JJ
cord-258536-qnn9hp8e	64	15	as	as	IN
cord-258536-qnn9hp8e	64	16	the	the	DT
cord-258536-qnn9hp8e	64	17	inactivation	inactivation	NN
cord-258536-qnn9hp8e	64	18	of	of	IN
cord-258536-qnn9hp8e	64	19	mTOR	mTOR	NNP
cord-258536-qnn9hp8e	64	20	,	,	,
cord-258536-qnn9hp8e	64	21	and	and	CC
cord-258536-qnn9hp8e	64	22	key	key	NN
cord-258536-qnn9hp8e	64	23	in	in	IN
cord-258536-qnn9hp8e	64	24	initiating	initiate	VBG
cord-258536-qnn9hp8e	64	25	the	the	DT
cord-258536-qnn9hp8e	64	26	formation	formation	NN
cord-258536-qnn9hp8e	64	27	of	of	IN
cord-258536-qnn9hp8e	64	28	an	an	DT
cord-258536-qnn9hp8e	64	29	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	64	30	,	,	,
cord-258536-qnn9hp8e	64	31	is	be	VBZ
cord-258536-qnn9hp8e	64	32	the	the	DT
cord-258536-qnn9hp8e	64	33	ULK	ULK	NNP
cord-258536-qnn9hp8e	64	34	kinase	kinase	NN
cord-258536-qnn9hp8e	64	35	complex	complex	NN
cord-258536-qnn9hp8e	64	36	,	,	,
cord-258536-qnn9hp8e	64	37	which	which	WDT
cord-258536-qnn9hp8e	64	38	is	be	VBZ
cord-258536-qnn9hp8e	64	39	composed	compose	VBN
cord-258536-qnn9hp8e	64	40	of	of	IN
cord-258536-qnn9hp8e	64	41	ULK1	ULK1	NNP
cord-258536-qnn9hp8e	64	42	or	or	CC
cord-258536-qnn9hp8e	64	43	ULK2	ULK2	NNP
cord-258536-qnn9hp8e	64	44	,	,	,
cord-258536-qnn9hp8e	64	45	ATG13	atg13	ADD
cord-258536-qnn9hp8e	64	46	,	,	,
cord-258536-qnn9hp8e	64	47	FAK	FAK	NNP
cord-258536-qnn9hp8e	64	48	family	family	NN
cord-258536-qnn9hp8e	64	49	kinase	kinase	NN
cord-258536-qnn9hp8e	64	50	-	-	:
cord-258536-qnn9hp8e	64	51	interacting	interact	VBG
cord-258536-qnn9hp8e	64	52	protein	protein	NN
cord-258536-qnn9hp8e	64	53	of	of	IN
cord-258536-qnn9hp8e	64	54	200	200	CD
cord-258536-qnn9hp8e	64	55	kDa	kDa	NNPS
cord-258536-qnn9hp8e	64	56	(	(	-LRB-
cord-258536-qnn9hp8e	64	57	FIP200	FIP200	NNP
cord-258536-qnn9hp8e	64	58	)	)	-RRB-
cord-258536-qnn9hp8e	64	59	,	,	,
cord-258536-qnn9hp8e	64	60	and	and	CC
cord-258536-qnn9hp8e	64	61	ATG101	ATG101	NNP
cord-258536-qnn9hp8e	64	62	[	[	-LRB-
cord-258536-qnn9hp8e	64	63	31	31	CD
cord-258536-qnn9hp8e	64	64	,	,	,
cord-258536-qnn9hp8e	64	65	39	39	CD
cord-258536-qnn9hp8e	64	66	]	]	-RRB-
cord-258536-qnn9hp8e	64	67	.	.	.
cord-258536-qnn9hp8e	65	1	The	the	DT
cord-258536-qnn9hp8e	65	2	class	class	NN
cord-258536-qnn9hp8e	66	1	III	III	NNP
cord-258536-qnn9hp8e	66	2	hVPS34	hVPS34	NNP
cord-258536-qnn9hp8e	66	3	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	66	4	3-kinase	3-kinase	CD
cord-258536-qnn9hp8e	66	5	,	,	,
cord-258536-qnn9hp8e	66	6	which	which	WDT
cord-258536-qnn9hp8e	66	7	is	be	VBZ
cord-258536-qnn9hp8e	66	8	part	part	NN
cord-258536-qnn9hp8e	66	9	of	of	IN
cord-258536-qnn9hp8e	66	10	a	a	DT
cord-258536-qnn9hp8e	66	11	complex	complex	NN
cord-258536-qnn9hp8e	66	12	including	include	VBG
cord-258536-qnn9hp8e	66	13	hVPS15	hVPS15	NNP
cord-258536-qnn9hp8e	66	14	,	,	,
cord-258536-qnn9hp8e	66	15	ATG14L1	ATG14L1	NNP
cord-258536-qnn9hp8e	66	16	,	,	,
cord-258536-qnn9hp8e	66	17	and	and	CC
cord-258536-qnn9hp8e	66	18	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	66	19	,	,	,
cord-258536-qnn9hp8e	66	20	generates	generate	VBZ
cord-258536-qnn9hp8e	66	21	the	the	DT
cord-258536-qnn9hp8e	66	22	pool	pool	NN
cord-258536-qnn9hp8e	66	23	of	of	IN
cord-258536-qnn9hp8e	66	24	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	66	25	3-phosphate	3-phosphate	CD
cord-258536-qnn9hp8e	66	26	(	(	-LRB-
cord-258536-qnn9hp8e	66	27	PtdIns3P	PtdIns3P	NNP
cord-258536-qnn9hp8e	66	28	)	)	-RRB-
cord-258536-qnn9hp8e	66	29	on	on	IN
cord-258536-qnn9hp8e	66	30	autophagosomal	autophagosomal	NNP
cord-258536-qnn9hp8e	66	31	membranes	membrane	NNS
cord-258536-qnn9hp8e	66	32	that	that	WDT
cord-258536-qnn9hp8e	66	33	facilitates	facilitate	VBZ
cord-258536-qnn9hp8e	66	34	the	the	DT
cord-258536-qnn9hp8e	66	35	recruitment	recruitment	NN
cord-258536-qnn9hp8e	66	36	of	of	IN
cord-258536-qnn9hp8e	66	37	PtdIns3P	PtdIns3P	NNS
cord-258536-qnn9hp8e	66	38	effectors	effector	NNS
cord-258536-qnn9hp8e	66	39	such	such	JJ
cord-258536-qnn9hp8e	66	40	as	as	IN
cord-258536-qnn9hp8e	66	41	double	double	JJ
cord-258536-qnn9hp8e	66	42	FYVE	FYVE	NNP
cord-258536-qnn9hp8e	66	43	-	-	HYPH
cord-258536-qnn9hp8e	66	44	containing	contain	VBG
cord-258536-qnn9hp8e	66	45	protein	protein	NN
cord-258536-qnn9hp8e	66	46	1	1	CD
cord-258536-qnn9hp8e	66	47	(	(	-LRB-
cord-258536-qnn9hp8e	66	48	DFCP1	DFCP1	NNP
cord-258536-qnn9hp8e	66	49	)	)	-RRB-
cord-258536-qnn9hp8e	66	50	and	and	CC
cord-258536-qnn9hp8e	66	51	the	the	DT
cord-258536-qnn9hp8e	66	52	human	human	JJ
cord-258536-qnn9hp8e	66	53	WD	WD	NNP
cord-258536-qnn9hp8e	66	54	-	-	HYPH
cord-258536-qnn9hp8e	66	55	repeat	repeat	NN
cord-258536-qnn9hp8e	66	56	protein	protein	NN
cord-258536-qnn9hp8e	66	57	interacting	interact	VBG
cord-258536-qnn9hp8e	66	58	with	with	IN
cord-258536-qnn9hp8e	66	59	phosphoinositides	phosphoinositide	NNS
cord-258536-qnn9hp8e	66	60	(	(	-LRB-
cord-258536-qnn9hp8e	66	61	WIPI	WIPI	NNP
cord-258536-qnn9hp8e	66	62	)	)	-RRB-
cord-258536-qnn9hp8e	66	63	proteins	protein	NNS
cord-258536-qnn9hp8e	66	64	[	[	-LRB-
cord-258536-qnn9hp8e	66	65	40	40	CD
cord-258536-qnn9hp8e	66	66	]	]	-RRB-
cord-258536-qnn9hp8e	67	1	[	[	-LRB-
cord-258536-qnn9hp8e	67	2	41	41	CD
cord-258536-qnn9hp8e	67	3	]	]	-RRB-
cord-258536-qnn9hp8e	68	1	[	[	-LRB-
cord-258536-qnn9hp8e	68	2	42	42	CD
cord-258536-qnn9hp8e	68	3	]	]	-RRB-
cord-258536-qnn9hp8e	68	4	[	[	-LRB-
cord-258536-qnn9hp8e	68	5	43	43	CD
cord-258536-qnn9hp8e	68	6	]	]	-RRB-
cord-258536-qnn9hp8e	68	7	[	[	-LRB-
cord-258536-qnn9hp8e	68	8	44	44	CD
cord-258536-qnn9hp8e	68	9	]	]	-RRB-
cord-258536-qnn9hp8e	68	10	[	[	-LRB-
cord-258536-qnn9hp8e	68	11	45	45	CD
cord-258536-qnn9hp8e	68	12	]	]	-RRB-
cord-258536-qnn9hp8e	68	13	.	.	.
cord-258536-qnn9hp8e	69	1	The	the	DT
cord-258536-qnn9hp8e	69	2	hVPS34-containing	hvps34-containe	VBG
cord-258536-qnn9hp8e	69	3	complex	complex	NN
cord-258536-qnn9hp8e	69	4	as	as	RB
cord-258536-qnn9hp8e	69	5	well	well	RB
cord-258536-qnn9hp8e	69	6	as	as	IN
cord-258536-qnn9hp8e	69	7	the	the	DT
cord-258536-qnn9hp8e	69	8	transmembrane	transmembrane	NN
cord-258536-qnn9hp8e	69	9	protein	protein	NN
cord-258536-qnn9hp8e	69	10	ATG9	ATG9	NNP
cord-258536-qnn9hp8e	69	11	,	,	,
cord-258536-qnn9hp8e	69	12	are	be	VBP
cord-258536-qnn9hp8e	69	13	two	two	CD
cord-258536-qnn9hp8e	69	14	other	other	JJ
cord-258536-qnn9hp8e	69	15	important	important	JJ
cord-258536-qnn9hp8e	69	16	factors	factor	NNS
cord-258536-qnn9hp8e	69	17	during	during	IN
cord-258536-qnn9hp8e	69	18	the	the	DT
cord-258536-qnn9hp8e	69	19	early	early	JJ
cord-258536-qnn9hp8e	69	20	stage	stage	NN
cord-258536-qnn9hp8e	69	21	of	of	IN
cord-258536-qnn9hp8e	69	22	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	69	23	biogenesis	biogenesis	NN
cord-258536-qnn9hp8e	69	24	[	[	-LRB-
cord-258536-qnn9hp8e	69	25	46	46	CD
cord-258536-qnn9hp8e	69	26	,	,	,
cord-258536-qnn9hp8e	69	27	47	47	CD
cord-258536-qnn9hp8e	69	28	]	]	-RRB-
cord-258536-qnn9hp8e	69	29	.	.	.
cord-258536-qnn9hp8e	70	1	Subsequently	subsequently	RB
cord-258536-qnn9hp8e	70	2	,	,	,
cord-258536-qnn9hp8e	70	3	two	two	CD
cord-258536-qnn9hp8e	70	4	ubiquitination	ubiquitination	NN
cord-258536-qnn9hp8e	70	5	-	-	HYPH
cord-258536-qnn9hp8e	70	6	like	like	JJ
cord-258536-qnn9hp8e	70	7	systems	system	NNS
cord-258536-qnn9hp8e	70	8	,	,	,
cord-258536-qnn9hp8e	70	9	which	which	WDT
cord-258536-qnn9hp8e	70	10	ultimately	ultimately	RB
cord-258536-qnn9hp8e	70	11	recruit	recruit	VBP
cord-258536-qnn9hp8e	70	12	members	member	NNS
cord-258536-qnn9hp8e	70	13	of	of	IN
cord-258536-qnn9hp8e	70	14	the	the	DT
cord-258536-qnn9hp8e	70	15	LC3	LC3	NNP
cord-258536-qnn9hp8e	70	16	/	/	SYM
cord-258536-qnn9hp8e	70	17	ATG8	ATG8	NNP
cord-258536-qnn9hp8e	70	18	protein	protein	NN
cord-258536-qnn9hp8e	70	19	family	family	NN
cord-258536-qnn9hp8e	70	20	onto	onto	IN
cord-258536-qnn9hp8e	70	21	autophagosomal	autophagosomal	NNP
cord-258536-qnn9hp8e	70	22	membranes	membrane	NNS
cord-258536-qnn9hp8e	70	23	through	through	IN
cord-258536-qnn9hp8e	70	24	their	-PRON-	PRP$
cord-258536-qnn9hp8e	70	25	conjugation	conjugation	NN
cord-258536-qnn9hp8e	70	26	to	to	IN
cord-258536-qnn9hp8e	70	27	phosphatidylethanolamine	phosphatidylethanolamine	NNP
cord-258536-qnn9hp8e	70	28	,	,	,
cord-258536-qnn9hp8e	70	29	are	be	VBP
cord-258536-qnn9hp8e	70	30	essential	essential	JJ
cord-258536-qnn9hp8e	70	31	for	for	IN
cord-258536-qnn9hp8e	70	32	the	the	DT
cord-258536-qnn9hp8e	70	33	completion	completion	NN
cord-258536-qnn9hp8e	70	34	of	of	IN
cord-258536-qnn9hp8e	70	35	the	the	DT
cord-258536-qnn9hp8e	70	36	forming	form	VBG
cord-258536-qnn9hp8e	70	37	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	70	38	[	[	-LRB-
cord-258536-qnn9hp8e	70	39	47	47	CD
cord-258536-qnn9hp8e	70	40	]	]	-RRB-
cord-258536-qnn9hp8e	70	41	.	.	.
cord-258536-qnn9hp8e	71	1	Finally	finally	RB
cord-258536-qnn9hp8e	71	2	,	,	,
cord-258536-qnn9hp8e	71	3	the	the	DT
cord-258536-qnn9hp8e	71	4	fusion	fusion	NN
cord-258536-qnn9hp8e	71	5	of	of	IN
cord-258536-qnn9hp8e	71	6	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	71	7	first	first	RB
cord-258536-qnn9hp8e	71	8	with	with	IN
cord-258536-qnn9hp8e	71	9	endosomes	endosome	NNS
cord-258536-qnn9hp8e	71	10	and	and	CC
cord-258536-qnn9hp8e	71	11	then	then	RB
cord-258536-qnn9hp8e	71	12	with	with	IN
cord-258536-qnn9hp8e	71	13	lysosomes	lysosome	NNS
cord-258536-qnn9hp8e	71	14	,	,	,
cord-258536-qnn9hp8e	71	15	leads	lead	VBZ
cord-258536-qnn9hp8e	71	16	to	to	IN
cord-258536-qnn9hp8e	71	17	the	the	DT
cord-258536-qnn9hp8e	71	18	formation	formation	NN
cord-258536-qnn9hp8e	71	19	of	of	IN
cord-258536-qnn9hp8e	71	20	amphisomes	amphisomes	NNP
cord-258536-qnn9hp8e	71	21	and	and	CC
cord-258536-qnn9hp8e	71	22	autolysosomes	autolysosomes	NNP
cord-258536-qnn9hp8e	71	23	,	,	,
cord-258536-qnn9hp8e	71	24	respectively	respectively	RB
cord-258536-qnn9hp8e	71	25	,	,	,
cord-258536-qnn9hp8e	71	26	where	where	WRB
cord-258536-qnn9hp8e	71	27	the	the	DT
cord-258536-qnn9hp8e	71	28	degradation	degradation	NN
cord-258536-qnn9hp8e	71	29	of	of	IN
cord-258536-qnn9hp8e	71	30	the	the	DT
cord-258536-qnn9hp8e	71	31	autophagy	autophagy	NN
cord-258536-qnn9hp8e	71	32	cargoes	cargo	NNS
cord-258536-qnn9hp8e	71	33	take	take	VBP
cord-258536-qnn9hp8e	71	34	place	place	NN
cord-258536-qnn9hp8e	71	35	[	[	-LRB-
cord-258536-qnn9hp8e	71	36	37	37	CD
cord-258536-qnn9hp8e	71	37	]	]	-RRB-
cord-258536-qnn9hp8e	71	38	.	.	.
cord-258536-qnn9hp8e	72	1	proteins	protein	NNS
cord-258536-qnn9hp8e	72	2	and	and	CC
cord-258536-qnn9hp8e	72	3	organelles	organelle	NNS
cord-258536-qnn9hp8e	72	4	,	,	,
cord-258536-qnn9hp8e	72	5	to	to	TO
cord-258536-qnn9hp8e	72	6	maintain	maintain	VB
cord-258536-qnn9hp8e	72	7	cellular	cellular	JJ
cord-258536-qnn9hp8e	72	8	energy	energy	NN
cord-258536-qnn9hp8e	72	9	levels	level	NNS
cord-258536-qnn9hp8e	72	10	and	and	CC
cord-258536-qnn9hp8e	72	11	ensure	ensure	VB
cord-258536-qnn9hp8e	72	12	survival	survival	NN
cord-258536-qnn9hp8e	72	13	[	[	-LRB-
cord-258536-qnn9hp8e	72	14	27	27	CD
cord-258536-qnn9hp8e	72	15	]	]	-RRB-
cord-258536-qnn9hp8e	72	16	[	[	-LRB-
cord-258536-qnn9hp8e	72	17	28	28	CD
cord-258536-qnn9hp8e	72	18	]	]	-RRB-
cord-258536-qnn9hp8e	72	19	[	[	-LRB-
cord-258536-qnn9hp8e	72	20	29	29	CD
cord-258536-qnn9hp8e	72	21	]	]	-RRB-
cord-258536-qnn9hp8e	72	22	[	[	-LRB-
cord-258536-qnn9hp8e	72	23	30	30	CD
cord-258536-qnn9hp8e	72	24	]	]	-RRB-
cord-258536-qnn9hp8e	72	25	[	[	-LRB-
cord-258536-qnn9hp8e	72	26	31	31	CD
cord-258536-qnn9hp8e	72	27	]	]	-RRB-
cord-258536-qnn9hp8e	73	1	[	[	-LRB-
cord-258536-qnn9hp8e	73	2	32	32	CD
cord-258536-qnn9hp8e	73	3	]	]	-RRB-
cord-258536-qnn9hp8e	73	4	[	[	-LRB-
cord-258536-qnn9hp8e	73	5	33	33	CD
cord-258536-qnn9hp8e	73	6	]	]	-RRB-
cord-258536-qnn9hp8e	73	7	[	[	-LRB-
cord-258536-qnn9hp8e	73	8	34	34	CD
cord-258536-qnn9hp8e	73	9	]	]	-RRB-
cord-258536-qnn9hp8e	73	10	[	[	-LRB-
cord-258536-qnn9hp8e	73	11	35	35	CD
cord-258536-qnn9hp8e	73	12	]	]	-RRB-
cord-258536-qnn9hp8e	73	13	.	.	.
cord-258536-qnn9hp8e	74	1	This	this	DT
cord-258536-qnn9hp8e	74	2	process	process	NN
cord-258536-qnn9hp8e	74	3	is	be	VBZ
cord-258536-qnn9hp8e	74	4	characterized	characterize	VBN
cord-258536-qnn9hp8e	74	5	by	by	IN
cord-258536-qnn9hp8e	74	6	double	double	JJ
cord-258536-qnn9hp8e	74	7	-	-	HYPH
cord-258536-qnn9hp8e	74	8	membrane	membrane	NN
cord-258536-qnn9hp8e	74	9	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	74	10	called	call	VBN
cord-258536-qnn9hp8e	74	11	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	74	12	,	,	,
cord-258536-qnn9hp8e	74	13	which	which	WDT
cord-258536-qnn9hp8e	74	14	sequester	sequester	VBP
cord-258536-qnn9hp8e	74	15	the	the	DT
cord-258536-qnn9hp8e	74	16	cytoplasmic	cytoplasmic	JJ
cord-258536-qnn9hp8e	74	17	components	component	NNS
cord-258536-qnn9hp8e	74	18	targeted	target	VBN
cord-258536-qnn9hp8e	74	19	to	to	IN
cord-258536-qnn9hp8e	74	20	destruction	destruction	NN
cord-258536-qnn9hp8e	74	21	and	and	CC
cord-258536-qnn9hp8e	74	22	deliver	deliver	VB
cord-258536-qnn9hp8e	74	23	them	-PRON-	PRP
cord-258536-qnn9hp8e	74	24	into	into	IN
cord-258536-qnn9hp8e	74	25	lysosomes	lysosome	NNS
cord-258536-qnn9hp8e	74	26	for	for	IN
cord-258536-qnn9hp8e	74	27	degradation	degradation	NN
cord-258536-qnn9hp8e	74	28	[	[	-LRB-
cord-258536-qnn9hp8e	74	29	33	33	CD
cord-258536-qnn9hp8e	74	30	]	]	-RRB-
cord-258536-qnn9hp8e	74	31	[	[	-LRB-
cord-258536-qnn9hp8e	74	32	34	34	CD
cord-258536-qnn9hp8e	74	33	]	]	-RRB-
cord-258536-qnn9hp8e	74	34	[	[	-LRB-
cord-258536-qnn9hp8e	74	35	35	35	CD
cord-258536-qnn9hp8e	74	36	]	]	-RRB-
cord-258536-qnn9hp8e	74	37	[	[	-LRB-
cord-258536-qnn9hp8e	74	38	36	36	CD
cord-258536-qnn9hp8e	74	39	]	]	-RRB-
cord-258536-qnn9hp8e	75	1	[	[	-LRB-
cord-258536-qnn9hp8e	75	2	37	37	CD
cord-258536-qnn9hp8e	75	3	]	]	-RRB-
cord-258536-qnn9hp8e	75	4	(	(	-LRB-
cord-258536-qnn9hp8e	75	5	Figure	figure	NN
cord-258536-qnn9hp8e	75	6	3	3	CD
cord-258536-qnn9hp8e	75	7	)	)	-RRB-
cord-258536-qnn9hp8e	75	8	.	.	.
cord-258536-qnn9hp8e	76	1	The	the	DT
cord-258536-qnn9hp8e	76	2	process	process	NN
cord-258536-qnn9hp8e	76	3	can	can	MD
cord-258536-qnn9hp8e	76	4	be	be	VB
cord-258536-qnn9hp8e	76	5	divided	divide	VBN
cord-258536-qnn9hp8e	76	6	into	into	IN
cord-258536-qnn9hp8e	76	7	three	three	CD
cord-258536-qnn9hp8e	76	8	different	different	JJ
cord-258536-qnn9hp8e	76	9	steps	step	NNS
cord-258536-qnn9hp8e	76	10	:	:	:
cord-258536-qnn9hp8e	76	11	The	the	DT
cord-258536-qnn9hp8e	76	12	initiation	initiation	NN
cord-258536-qnn9hp8e	76	13	step	step	NN
cord-258536-qnn9hp8e	76	14	,	,	,
cord-258536-qnn9hp8e	76	15	when	when	WRB
cord-258536-qnn9hp8e	76	16	the	the	DT
cord-258536-qnn9hp8e	76	17	phagophore	phagophore	NN
cord-258536-qnn9hp8e	76	18	or	or	CC
cord-258536-qnn9hp8e	76	19	isolation	isolation	NN
cord-258536-qnn9hp8e	76	20	membrane	membrane	NN
cord-258536-qnn9hp8e	76	21	is	be	VBZ
cord-258536-qnn9hp8e	76	22	formed	form	VBN
cord-258536-qnn9hp8e	76	23	,	,	,
cord-258536-qnn9hp8e	76	24	the	the	DT
cord-258536-qnn9hp8e	76	25	elongation	elongation	NN
cord-258536-qnn9hp8e	76	26	step	step	NN
cord-258536-qnn9hp8e	76	27	,	,	,
cord-258536-qnn9hp8e	76	28	during	during	IN
cord-258536-qnn9hp8e	76	29	which	which	WDT
cord-258536-qnn9hp8e	76	30	the	the	DT
cord-258536-qnn9hp8e	76	31	phagophore	phagophore	NN
cord-258536-qnn9hp8e	76	32	expands	expand	VBZ
cord-258536-qnn9hp8e	76	33	and	and	CC
cord-258536-qnn9hp8e	76	34	close	close	JJ
cord-258536-qnn9hp8e	76	35	to	to	TO
cord-258536-qnn9hp8e	76	36	generate	generate	VB
cord-258536-qnn9hp8e	76	37	an	an	DT
cord-258536-qnn9hp8e	76	38	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	76	39	,	,	,
cord-258536-qnn9hp8e	76	40	and	and	CC
cord-258536-qnn9hp8e	76	41	the	the	DT
cord-258536-qnn9hp8e	76	42	maturation	maturation	NN
cord-258536-qnn9hp8e	76	43	step	step	NN
cord-258536-qnn9hp8e	76	44	,	,	,
cord-258536-qnn9hp8e	76	45	where	where	WRB
cord-258536-qnn9hp8e	76	46	the	the	DT
cord-258536-qnn9hp8e	76	47	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	76	48	fuses	fuse	VBZ
cord-258536-qnn9hp8e	76	49	with	with	IN
cord-258536-qnn9hp8e	76	50	the	the	DT
cord-258536-qnn9hp8e	76	51	lysosome	lysosome	NN
cord-258536-qnn9hp8e	76	52	(	(	-LRB-
cord-258536-qnn9hp8e	76	53	Figure	figure	NN
cord-258536-qnn9hp8e	76	54	3	3	CD
cord-258536-qnn9hp8e	76	55	)	)	-RRB-
cord-258536-qnn9hp8e	76	56	.	.	.
cord-258536-qnn9hp8e	77	1	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	77	2	is	be	VBZ
cord-258536-qnn9hp8e	77	3	regulated	regulate	VBN
cord-258536-qnn9hp8e	77	4	by	by	IN
cord-258536-qnn9hp8e	77	5	several	several	JJ
cord-258536-qnn9hp8e	77	6	signaling	signaling	NN
cord-258536-qnn9hp8e	77	7	cascades	cascade	NNS
cord-258536-qnn9hp8e	77	8	,	,	,
cord-258536-qnn9hp8e	77	9	including	include	VBG
cord-258536-qnn9hp8e	77	10	the	the	DT
cord-258536-qnn9hp8e	77	11	one	one	NN
cord-258536-qnn9hp8e	77	12	centered	center	VBN
cord-258536-qnn9hp8e	77	13	on	on	IN
cord-258536-qnn9hp8e	77	14	the	the	DT
cord-258536-qnn9hp8e	77	15	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	77	16	target	target	NN
cord-258536-qnn9hp8e	77	17	of	of	IN
cord-258536-qnn9hp8e	77	18	rapamycin	rapamycin	NNP
cord-258536-qnn9hp8e	77	19	(	(	-LRB-
cord-258536-qnn9hp8e	77	20	mTOR	mTOR	NNP
cord-258536-qnn9hp8e	77	21	)	)	-RRB-
cord-258536-qnn9hp8e	77	22	[	[	-LRB-
cord-258536-qnn9hp8e	77	23	34	34	CD
cord-258536-qnn9hp8e	77	24	,	,	,
cord-258536-qnn9hp8e	77	25	35	35	CD
cord-258536-qnn9hp8e	77	26	,	,	,
cord-258536-qnn9hp8e	77	27	38	38	CD
cord-258536-qnn9hp8e	77	28	]	]	-RRB-
cord-258536-qnn9hp8e	77	29	.	.	.
cord-258536-qnn9hp8e	78	1	Autophagosomes	Autophagosomes	NNP
cord-258536-qnn9hp8e	78	2	are	be	VBP
cord-258536-qnn9hp8e	78	3	formed	form	VBN
cord-258536-qnn9hp8e	78	4	through	through	IN
cord-258536-qnn9hp8e	78	5	the	the	DT
cord-258536-qnn9hp8e	78	6	concerted	concerted	JJ
cord-258536-qnn9hp8e	78	7	action	action	NN
cord-258536-qnn9hp8e	78	8	of	of	IN
cord-258536-qnn9hp8e	78	9	the	the	DT
cord-258536-qnn9hp8e	78	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	78	11	-	-	HYPH
cord-258536-qnn9hp8e	78	12	related	relate	VBN
cord-258536-qnn9hp8e	78	13	(	(	-LRB-
cord-258536-qnn9hp8e	78	14	ATG	ATG	NNP
cord-258536-qnn9hp8e	78	15	)	)	-RRB-
cord-258536-qnn9hp8e	78	16	genes	gene	NNS
cord-258536-qnn9hp8e	78	17	[	[	-LRB-
cord-258536-qnn9hp8e	78	18	29	29	CD
cord-258536-qnn9hp8e	78	19	,	,	,
cord-258536-qnn9hp8e	78	20	33	33	CD
cord-258536-qnn9hp8e	78	21	]	]	-RRB-
cord-258536-qnn9hp8e	78	22	.	.	.
cord-258536-qnn9hp8e	79	1	The	the	DT
cord-258536-qnn9hp8e	79	2	proteins	protein	NNS
cord-258536-qnn9hp8e	79	3	encoded	encode	VBN
cord-258536-qnn9hp8e	79	4	by	by	IN
cord-258536-qnn9hp8e	79	5	the	the	DT
cord-258536-qnn9hp8e	79	6	ATG	ATG	NNP
cord-258536-qnn9hp8e	79	7	genes	gene	NNS
cord-258536-qnn9hp8e	79	8	have	have	VBP
cord-258536-qnn9hp8e	79	9	been	be	VBN
cord-258536-qnn9hp8e	79	10	classified	classify	VBN
cord-258536-qnn9hp8e	79	11	in	in	IN
cord-258536-qnn9hp8e	79	12	five	five	CD
cord-258536-qnn9hp8e	79	13	functional	functional	JJ
cord-258536-qnn9hp8e	79	14	groups	group	NNS
cord-258536-qnn9hp8e	79	15	.	.	.
cord-258536-qnn9hp8e	80	1	The	the	DT
cord-258536-qnn9hp8e	80	2	unc-51	unc-51	JJ
cord-258536-qnn9hp8e	80	3	like	like	IN
cord-258536-qnn9hp8e	80	4	autophagy	autophagy	NN
cord-258536-qnn9hp8e	80	5	activating	activate	VBG
cord-258536-qnn9hp8e	80	6	kinase	kinase	NN
cord-258536-qnn9hp8e	80	7	(	(	-LRB-
cord-258536-qnn9hp8e	80	8	ULK	ULK	NNP
cord-258536-qnn9hp8e	80	9	)	)	-RRB-
cord-258536-qnn9hp8e	81	1	kinase	kinase	NN
cord-258536-qnn9hp8e	81	2	complex	complex	NN
cord-258536-qnn9hp8e	81	3	,	,	,
cord-258536-qnn9hp8e	81	4	the	the	DT
cord-258536-qnn9hp8e	81	5	class	class	NN
cord-258536-qnn9hp8e	81	6	III	iii	CD
cord-258536-qnn9hp8e	81	7	hVPS34	hVPS34	NNP
cord-258536-qnn9hp8e	81	8	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	81	9	3-kinase	3-kinase	CD
cord-258536-qnn9hp8e	81	10	complex	complex	NN
cord-258536-qnn9hp8e	81	11	,	,	,
cord-258536-qnn9hp8e	81	12	and	and	CC
cord-258536-qnn9hp8e	81	13	the	the	DT
cord-258536-qnn9hp8e	81	14	ATG9	ATG9	NNP
cord-258536-qnn9hp8e	81	15	cycling	cycling	NN
cord-258536-qnn9hp8e	81	16	system	system	NN
cord-258536-qnn9hp8e	81	17	,	,	,
cord-258536-qnn9hp8e	81	18	on	on	IN
cord-258536-qnn9hp8e	81	19	one	one	CD
cord-258536-qnn9hp8e	81	20	hand	hand	NN
cord-258536-qnn9hp8e	81	21	,	,	,
cord-258536-qnn9hp8e	81	22	play	play	VB
cord-258536-qnn9hp8e	81	23	a	a	DT
cord-258536-qnn9hp8e	81	24	key	key	JJ
cord-258536-qnn9hp8e	81	25	role	role	NN
cord-258536-qnn9hp8e	81	26	in	in	IN
cord-258536-qnn9hp8e	81	27	the	the	DT
cord-258536-qnn9hp8e	81	28	initiation	initiation	NN
cord-258536-qnn9hp8e	81	29	of	of	IN
cord-258536-qnn9hp8e	81	30	autophagy	autophagy	NN
cord-258536-qnn9hp8e	81	31	and	and	CC
cord-258536-qnn9hp8e	81	32	phagophore	phagophore	NN
cord-258536-qnn9hp8e	81	33	formation	formation	NN
cord-258536-qnn9hp8e	81	34	.	.	.
cord-258536-qnn9hp8e	82	1	The	the	DT
cord-258536-qnn9hp8e	82	2	ATG12	ATG12	NNP
cord-258536-qnn9hp8e	82	3	and	and	CC
cord-258536-qnn9hp8e	82	4	microtubule	microtubule	NN
cord-258536-qnn9hp8e	82	5	-	-	HYPH
cord-258536-qnn9hp8e	82	6	associated	associate	VBN
cord-258536-qnn9hp8e	82	7	protein	protein	NN
cord-258536-qnn9hp8e	82	8	light	light	NN
cord-258536-qnn9hp8e	82	9	chain	chain	NN
cord-258536-qnn9hp8e	82	10	3	3	CD
cord-258536-qnn9hp8e	83	1	(	(	-LRB-
cord-258536-qnn9hp8e	83	2	LC3	LC3	NNP
cord-258536-qnn9hp8e	83	3	)	)	-RRB-
cord-258536-qnn9hp8e	83	4	conjugation	conjugation	NN
cord-258536-qnn9hp8e	83	5	systems	system	NNS
cord-258536-qnn9hp8e	83	6	,	,	,
cord-258536-qnn9hp8e	83	7	on	on	IN
cord-258536-qnn9hp8e	83	8	the	the	DT
cord-258536-qnn9hp8e	83	9	other	other	JJ
cord-258536-qnn9hp8e	83	10	hand	hand	NN
cord-258536-qnn9hp8e	83	11	,	,	,
cord-258536-qnn9hp8e	83	12	mediate	mediate	VB
cord-258536-qnn9hp8e	83	13	the	the	DT
cord-258536-qnn9hp8e	83	14	elongation	elongation	NN
cord-258536-qnn9hp8e	83	15	and	and	CC
cord-258536-qnn9hp8e	83	16	closure	closure	NN
cord-258536-qnn9hp8e	83	17	of	of	IN
cord-258536-qnn9hp8e	83	18	the	the	DT
cord-258536-qnn9hp8e	83	19	phagophore	phagophore	NN
cord-258536-qnn9hp8e	83	20	.	.	.
cord-258536-qnn9hp8e	84	1	The	the	DT
cord-258536-qnn9hp8e	84	2	first	first	JJ
cord-258536-qnn9hp8e	84	3	of	of	IN
cord-258536-qnn9hp8e	84	4	these	these	DT
cord-258536-qnn9hp8e	84	5	ATG	ATG	NNP
cord-258536-qnn9hp8e	84	6	protein	protein	NN
cord-258536-qnn9hp8e	84	7	complexes	complex	NNS
cord-258536-qnn9hp8e	84	8	responds	respond	VBZ
cord-258536-qnn9hp8e	84	9	to	to	TO
cord-258536-qnn9hp8e	84	10	upstream	upstream	VB
cord-258536-qnn9hp8e	84	11	regulatory	regulatory	JJ
cord-258536-qnn9hp8e	84	12	signals	signal	NNS
cord-258536-qnn9hp8e	84	13	,	,	,
cord-258536-qnn9hp8e	84	14	such	such	JJ
cord-258536-qnn9hp8e	84	15	as	as	IN
cord-258536-qnn9hp8e	84	16	the	the	DT
cord-258536-qnn9hp8e	84	17	inactivation	inactivation	NN
cord-258536-qnn9hp8e	84	18	of	of	IN
cord-258536-qnn9hp8e	84	19	mTOR	mTOR	NNP
cord-258536-qnn9hp8e	84	20	,	,	,
cord-258536-qnn9hp8e	84	21	and	and	CC
cord-258536-qnn9hp8e	84	22	key	key	NN
cord-258536-qnn9hp8e	84	23	in	in	IN
cord-258536-qnn9hp8e	84	24	initiating	initiate	VBG
cord-258536-qnn9hp8e	84	25	the	the	DT
cord-258536-qnn9hp8e	84	26	formation	formation	NN
cord-258536-qnn9hp8e	84	27	of	of	IN
cord-258536-qnn9hp8e	84	28	an	an	DT
cord-258536-qnn9hp8e	84	29	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	84	30	,	,	,
cord-258536-qnn9hp8e	84	31	is	be	VBZ
cord-258536-qnn9hp8e	84	32	the	the	DT
cord-258536-qnn9hp8e	84	33	ULK	ULK	NNP
cord-258536-qnn9hp8e	84	34	kinase	kinase	NN
cord-258536-qnn9hp8e	84	35	complex	complex	NN
cord-258536-qnn9hp8e	84	36	,	,	,
cord-258536-qnn9hp8e	84	37	which	which	WDT
cord-258536-qnn9hp8e	84	38	is	be	VBZ
cord-258536-qnn9hp8e	84	39	composed	compose	VBN
cord-258536-qnn9hp8e	84	40	of	of	IN
cord-258536-qnn9hp8e	84	41	ULK1	ULK1	NNP
cord-258536-qnn9hp8e	84	42	or	or	CC
cord-258536-qnn9hp8e	84	43	ULK2	ULK2	NNP
cord-258536-qnn9hp8e	84	44	,	,	,
cord-258536-qnn9hp8e	84	45	ATG13	atg13	ADD
cord-258536-qnn9hp8e	84	46	,	,	,
cord-258536-qnn9hp8e	84	47	FAK	FAK	NNP
cord-258536-qnn9hp8e	84	48	family	family	NN
cord-258536-qnn9hp8e	84	49	kinaseinteracting	kinaseinteracte	VBG
cord-258536-qnn9hp8e	84	50	protein	protein	NN
cord-258536-qnn9hp8e	84	51	of	of	IN
cord-258536-qnn9hp8e	84	52	200	200	CD
cord-258536-qnn9hp8e	84	53	kDa	kDa	NNPS
cord-258536-qnn9hp8e	84	54	(	(	-LRB-
cord-258536-qnn9hp8e	84	55	FIP200	FIP200	NNP
cord-258536-qnn9hp8e	84	56	)	)	-RRB-
cord-258536-qnn9hp8e	84	57	,	,	,
cord-258536-qnn9hp8e	84	58	and	and	CC
cord-258536-qnn9hp8e	84	59	ATG101	ATG101	NNP
cord-258536-qnn9hp8e	84	60	[	[	-LRB-
cord-258536-qnn9hp8e	84	61	31	31	CD
cord-258536-qnn9hp8e	84	62	,	,	,
cord-258536-qnn9hp8e	84	63	39	39	CD
cord-258536-qnn9hp8e	84	64	]	]	-RRB-
cord-258536-qnn9hp8e	84	65	.	.	.
cord-258536-qnn9hp8e	85	1	The	the	DT
cord-258536-qnn9hp8e	85	2	class	class	NN
cord-258536-qnn9hp8e	86	1	III	III	NNP
cord-258536-qnn9hp8e	86	2	hVPS34	hVPS34	NNP
cord-258536-qnn9hp8e	86	3	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	86	4	3-kinase	3-kinase	CD
cord-258536-qnn9hp8e	86	5	,	,	,
cord-258536-qnn9hp8e	86	6	which	which	WDT
cord-258536-qnn9hp8e	86	7	is	be	VBZ
cord-258536-qnn9hp8e	86	8	part	part	NN
cord-258536-qnn9hp8e	86	9	of	of	IN
cord-258536-qnn9hp8e	86	10	a	a	DT
cord-258536-qnn9hp8e	86	11	complex	complex	NN
cord-258536-qnn9hp8e	86	12	including	include	VBG
cord-258536-qnn9hp8e	86	13	hVPS15	hVPS15	NNP
cord-258536-qnn9hp8e	86	14	,	,	,
cord-258536-qnn9hp8e	86	15	ATG14L1	ATG14L1	NNP
cord-258536-qnn9hp8e	86	16	,	,	,
cord-258536-qnn9hp8e	86	17	and	and	CC
cord-258536-qnn9hp8e	86	18	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	86	19	,	,	,
cord-258536-qnn9hp8e	86	20	generates	generate	VBZ
cord-258536-qnn9hp8e	86	21	the	the	DT
cord-258536-qnn9hp8e	86	22	pool	pool	NN
cord-258536-qnn9hp8e	86	23	of	of	IN
cord-258536-qnn9hp8e	86	24	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	86	25	3-phosphate	3-phosphate	CD
cord-258536-qnn9hp8e	86	26	(	(	-LRB-
cord-258536-qnn9hp8e	86	27	PtdIns3P	PtdIns3P	NNP
cord-258536-qnn9hp8e	86	28	)	)	-RRB-
cord-258536-qnn9hp8e	86	29	on	on	IN
cord-258536-qnn9hp8e	86	30	autophagosomal	autophagosomal	NNP
cord-258536-qnn9hp8e	86	31	membranes	membrane	NNS
cord-258536-qnn9hp8e	86	32	that	that	WDT
cord-258536-qnn9hp8e	86	33	facilitates	facilitate	VBZ
cord-258536-qnn9hp8e	86	34	the	the	DT
cord-258536-qnn9hp8e	86	35	recruitment	recruitment	NN
cord-258536-qnn9hp8e	86	36	of	of	IN
cord-258536-qnn9hp8e	86	37	PtdIns3P	PtdIns3P	NNS
cord-258536-qnn9hp8e	86	38	effectors	effector	NNS
cord-258536-qnn9hp8e	86	39	such	such	JJ
cord-258536-qnn9hp8e	86	40	as	as	IN
cord-258536-qnn9hp8e	86	41	double	double	JJ
cord-258536-qnn9hp8e	86	42	FYVE	FYVE	NNP
cord-258536-qnn9hp8e	86	43	-	-	HYPH
cord-258536-qnn9hp8e	86	44	containing	contain	VBG
cord-258536-qnn9hp8e	86	45	protein	protein	NN
cord-258536-qnn9hp8e	86	46	1	1	CD
cord-258536-qnn9hp8e	86	47	(	(	-LRB-
cord-258536-qnn9hp8e	86	48	DFCP1	DFCP1	NNP
cord-258536-qnn9hp8e	86	49	)	)	-RRB-
cord-258536-qnn9hp8e	86	50	and	and	CC
cord-258536-qnn9hp8e	86	51	the	the	DT
cord-258536-qnn9hp8e	86	52	human	human	JJ
cord-258536-qnn9hp8e	86	53	WD	WD	NNP
cord-258536-qnn9hp8e	86	54	-	-	HYPH
cord-258536-qnn9hp8e	86	55	repeat	repeat	NN
cord-258536-qnn9hp8e	86	56	protein	protein	NN
cord-258536-qnn9hp8e	86	57	interacting	interact	VBG
cord-258536-qnn9hp8e	86	58	with	with	IN
cord-258536-qnn9hp8e	86	59	phosphoinositides	phosphoinositide	NNS
cord-258536-qnn9hp8e	86	60	(	(	-LRB-
cord-258536-qnn9hp8e	86	61	WIPI	WIPI	NNP
cord-258536-qnn9hp8e	86	62	)	)	-RRB-
cord-258536-qnn9hp8e	86	63	proteins	protein	NNS
cord-258536-qnn9hp8e	86	64	[	[	-LRB-
cord-258536-qnn9hp8e	86	65	40	40	CD
cord-258536-qnn9hp8e	86	66	]	]	-RRB-
cord-258536-qnn9hp8e	87	1	[	[	-LRB-
cord-258536-qnn9hp8e	87	2	41	41	CD
cord-258536-qnn9hp8e	87	3	]	]	-RRB-
cord-258536-qnn9hp8e	88	1	[	[	-LRB-
cord-258536-qnn9hp8e	88	2	42	42	CD
cord-258536-qnn9hp8e	88	3	]	]	-RRB-
cord-258536-qnn9hp8e	88	4	[	[	-LRB-
cord-258536-qnn9hp8e	88	5	43	43	CD
cord-258536-qnn9hp8e	88	6	]	]	-RRB-
cord-258536-qnn9hp8e	88	7	[	[	-LRB-
cord-258536-qnn9hp8e	88	8	44	44	CD
cord-258536-qnn9hp8e	88	9	]	]	-RRB-
cord-258536-qnn9hp8e	88	10	[	[	-LRB-
cord-258536-qnn9hp8e	88	11	45	45	CD
cord-258536-qnn9hp8e	88	12	]	]	-RRB-
cord-258536-qnn9hp8e	88	13	.	.	.
cord-258536-qnn9hp8e	89	1	The	the	DT
cord-258536-qnn9hp8e	89	2	hVPS34-containing	hvps34-containe	VBG
cord-258536-qnn9hp8e	89	3	complex	complex	NN
cord-258536-qnn9hp8e	89	4	as	as	RB
cord-258536-qnn9hp8e	89	5	well	well	RB
cord-258536-qnn9hp8e	89	6	as	as	IN
cord-258536-qnn9hp8e	89	7	the	the	DT
cord-258536-qnn9hp8e	89	8	transmembrane	transmembrane	NN
cord-258536-qnn9hp8e	89	9	protein	protein	NN
cord-258536-qnn9hp8e	89	10	ATG9	ATG9	NNP
cord-258536-qnn9hp8e	89	11	,	,	,
cord-258536-qnn9hp8e	89	12	are	be	VBP
cord-258536-qnn9hp8e	89	13	two	two	CD
cord-258536-qnn9hp8e	89	14	other	other	JJ
cord-258536-qnn9hp8e	89	15	important	important	JJ
cord-258536-qnn9hp8e	89	16	factors	factor	NNS
cord-258536-qnn9hp8e	89	17	during	during	IN
cord-258536-qnn9hp8e	89	18	the	the	DT
cord-258536-qnn9hp8e	89	19	early	early	JJ
cord-258536-qnn9hp8e	89	20	stage	stage	NN
cord-258536-qnn9hp8e	89	21	of	of	IN
cord-258536-qnn9hp8e	89	22	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	89	23	biogenesis	biogenesis	NN
cord-258536-qnn9hp8e	89	24	[	[	-LRB-
cord-258536-qnn9hp8e	89	25	46	46	CD
cord-258536-qnn9hp8e	89	26	,	,	,
cord-258536-qnn9hp8e	89	27	47	47	CD
cord-258536-qnn9hp8e	89	28	]	]	-RRB-
cord-258536-qnn9hp8e	89	29	.	.	.
cord-258536-qnn9hp8e	90	1	Subsequently	subsequently	RB
cord-258536-qnn9hp8e	90	2	,	,	,
cord-258536-qnn9hp8e	90	3	two	two	CD
cord-258536-qnn9hp8e	90	4	ubiquitination	ubiquitination	NN
cord-258536-qnn9hp8e	90	5	-	-	HYPH
cord-258536-qnn9hp8e	90	6	like	like	JJ
cord-258536-qnn9hp8e	90	7	systems	system	NNS
cord-258536-qnn9hp8e	90	8	,	,	,
cord-258536-qnn9hp8e	90	9	which	which	WDT
cord-258536-qnn9hp8e	90	10	ultimately	ultimately	RB
cord-258536-qnn9hp8e	90	11	recruit	recruit	VBP
cord-258536-qnn9hp8e	90	12	members	member	NNS
cord-258536-qnn9hp8e	90	13	of	of	IN
cord-258536-qnn9hp8e	90	14	the	the	DT
cord-258536-qnn9hp8e	90	15	LC3	LC3	NNP
cord-258536-qnn9hp8e	90	16	/	/	SYM
cord-258536-qnn9hp8e	90	17	ATG8	ATG8	NNP
cord-258536-qnn9hp8e	90	18	protein	protein	NN
cord-258536-qnn9hp8e	90	19	family	family	NN
cord-258536-qnn9hp8e	90	20	onto	onto	IN
cord-258536-qnn9hp8e	90	21	autophagosomal	autophagosomal	NNP
cord-258536-qnn9hp8e	90	22	membranes	membrane	NNS
cord-258536-qnn9hp8e	90	23	through	through	IN
cord-258536-qnn9hp8e	90	24	their	-PRON-	PRP$
cord-258536-qnn9hp8e	90	25	conjugation	conjugation	NN
cord-258536-qnn9hp8e	90	26	to	to	IN
cord-258536-qnn9hp8e	90	27	phosphatidylethanolamine	phosphatidylethanolamine	NNP
cord-258536-qnn9hp8e	90	28	,	,	,
cord-258536-qnn9hp8e	90	29	are	be	VBP
cord-258536-qnn9hp8e	90	30	essential	essential	JJ
cord-258536-qnn9hp8e	90	31	for	for	IN
cord-258536-qnn9hp8e	90	32	the	the	DT
cord-258536-qnn9hp8e	90	33	completion	completion	NN
cord-258536-qnn9hp8e	90	34	of	of	IN
cord-258536-qnn9hp8e	90	35	the	the	DT
cord-258536-qnn9hp8e	90	36	forming	form	VBG
cord-258536-qnn9hp8e	90	37	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	90	38	[	[	-LRB-
cord-258536-qnn9hp8e	90	39	47	47	CD
cord-258536-qnn9hp8e	90	40	]	]	-RRB-
cord-258536-qnn9hp8e	90	41	.	.	.
cord-258536-qnn9hp8e	91	1	Finally	finally	RB
cord-258536-qnn9hp8e	91	2	,	,	,
cord-258536-qnn9hp8e	91	3	the	the	DT
cord-258536-qnn9hp8e	91	4	fusion	fusion	NN
cord-258536-qnn9hp8e	91	5	of	of	IN
cord-258536-qnn9hp8e	91	6	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	91	7	first	first	RB
cord-258536-qnn9hp8e	91	8	with	with	IN
cord-258536-qnn9hp8e	91	9	endosomes	endosome	NNS
cord-258536-qnn9hp8e	91	10	and	and	CC
cord-258536-qnn9hp8e	91	11	then	then	RB
cord-258536-qnn9hp8e	91	12	with	with	IN
cord-258536-qnn9hp8e	91	13	lysosomes	lysosome	NNS
cord-258536-qnn9hp8e	91	14	,	,	,
cord-258536-qnn9hp8e	91	15	leads	lead	VBZ
cord-258536-qnn9hp8e	91	16	to	to	IN
cord-258536-qnn9hp8e	91	17	the	the	DT
cord-258536-qnn9hp8e	91	18	formation	formation	NN
cord-258536-qnn9hp8e	91	19	of	of	IN
cord-258536-qnn9hp8e	91	20	amphisomes	amphisomes	NNP
cord-258536-qnn9hp8e	91	21	and	and	CC
cord-258536-qnn9hp8e	91	22	autolysosomes	autolysosomes	NNP
cord-258536-qnn9hp8e	91	23	,	,	,
cord-258536-qnn9hp8e	91	24	respectively	respectively	RB
cord-258536-qnn9hp8e	91	25	,	,	,
cord-258536-qnn9hp8e	91	26	where	where	WRB
cord-258536-qnn9hp8e	91	27	the	the	DT
cord-258536-qnn9hp8e	91	28	degradation	degradation	NN
cord-258536-qnn9hp8e	91	29	of	of	IN
cord-258536-qnn9hp8e	91	30	the	the	DT
cord-258536-qnn9hp8e	91	31	autophagy	autophagy	NN
cord-258536-qnn9hp8e	91	32	cargoes	cargo	NNS
cord-258536-qnn9hp8e	91	33	take	take	VBP
cord-258536-qnn9hp8e	91	34	place	place	NN
cord-258536-qnn9hp8e	91	35	[	[	-LRB-
cord-258536-qnn9hp8e	91	36	37	37	CD
cord-258536-qnn9hp8e	91	37	]	]	-RRB-
cord-258536-qnn9hp8e	91	38	.	.	.
cord-258536-qnn9hp8e	92	1	It	-PRON-	PRP
cord-258536-qnn9hp8e	92	2	has	have	VBZ
cord-258536-qnn9hp8e	92	3	long	long	RB
cord-258536-qnn9hp8e	92	4	been	be	VBN
cord-258536-qnn9hp8e	92	5	believed	believe	VBN
cord-258536-qnn9hp8e	92	6	that	that	IN
cord-258536-qnn9hp8e	92	7	the	the	DT
cord-258536-qnn9hp8e	92	8	ATG	ATG	NNP
cord-258536-qnn9hp8e	92	9	proteome	proteome	NN
cord-258536-qnn9hp8e	92	10	is	be	VBZ
cord-258536-qnn9hp8e	92	11	exclusively	exclusively	RB
cord-258536-qnn9hp8e	92	12	involved	involve	VBN
cord-258536-qnn9hp8e	92	13	in	in	IN
cord-258536-qnn9hp8e	92	14	autophagy	autophagy	NN
cord-258536-qnn9hp8e	92	15	,	,	,
cord-258536-qnn9hp8e	92	16	but	but	CC
cord-258536-qnn9hp8e	92	17	recent	recent	JJ
cord-258536-qnn9hp8e	92	18	findings	finding	NNS
cord-258536-qnn9hp8e	92	19	have	have	VBP
cord-258536-qnn9hp8e	92	20	revealed	reveal	VBN
cord-258536-qnn9hp8e	92	21	that	that	IN
cord-258536-qnn9hp8e	92	22	single	single	JJ
cord-258536-qnn9hp8e	92	23	ATG	ATG	NNP
cord-258536-qnn9hp8e	92	24	genes	gene	NNS
cord-258536-qnn9hp8e	92	25	or	or	CC
cord-258536-qnn9hp8e	92	26	functional	functional	JJ
cord-258536-qnn9hp8e	92	27	clusters	cluster	NNS
cord-258536-qnn9hp8e	92	28	of	of	IN
cord-258536-qnn9hp8e	92	29	ATG	ATG	NNP
cord-258536-qnn9hp8e	92	30	genes	gene	NNS
cord-258536-qnn9hp8e	92	31	fulfill	fulfill	VBP
cord-258536-qnn9hp8e	92	32	important	important	JJ
cord-258536-qnn9hp8e	92	33	cellular	cellular	JJ
cord-258536-qnn9hp8e	92	34	functions	function	NNS
cord-258536-qnn9hp8e	92	35	outside	outside	IN
cord-258536-qnn9hp8e	92	36	the	the	DT
cord-258536-qnn9hp8e	92	37	context	context	NN
cord-258536-qnn9hp8e	92	38	of	of	IN
cord-258536-qnn9hp8e	92	39	their	-PRON-	PRP$
cord-258536-qnn9hp8e	92	40	role	role	NN
cord-258536-qnn9hp8e	92	41	in	in	IN
cord-258536-qnn9hp8e	92	42	autophagy	autophagy	NN
cord-258536-qnn9hp8e	92	43	[	[	-LRB-
cord-258536-qnn9hp8e	92	44	48	48	CD
cord-258536-qnn9hp8e	92	45	]	]	-RRB-
cord-258536-qnn9hp8e	92	46	[	[	-LRB-
cord-258536-qnn9hp8e	92	47	49	49	CD
cord-258536-qnn9hp8e	92	48	]	]	-RRB-
cord-258536-qnn9hp8e	92	49	[	[	-LRB-
cord-258536-qnn9hp8e	92	50	50	50	CD
cord-258536-qnn9hp8e	92	51	]	]	-RRB-
cord-258536-qnn9hp8e	92	52	.	.	.
cord-258536-qnn9hp8e	93	1	Some	some	DT
cord-258536-qnn9hp8e	93	2	of	of	IN
cord-258536-qnn9hp8e	93	3	these	these	DT
cord-258536-qnn9hp8e	93	4	functions	function	NNS
cord-258536-qnn9hp8e	93	5	have	have	VBP
cord-258536-qnn9hp8e	93	6	It	-PRON-	PRP
cord-258536-qnn9hp8e	93	7	has	have	VBZ
cord-258536-qnn9hp8e	93	8	long	long	RB
cord-258536-qnn9hp8e	93	9	been	be	VBN
cord-258536-qnn9hp8e	93	10	believed	believe	VBN
cord-258536-qnn9hp8e	93	11	that	that	IN
cord-258536-qnn9hp8e	93	12	the	the	DT
cord-258536-qnn9hp8e	93	13	ATG	ATG	NNP
cord-258536-qnn9hp8e	93	14	proteome	proteome	NN
cord-258536-qnn9hp8e	93	15	is	be	VBZ
cord-258536-qnn9hp8e	93	16	exclusively	exclusively	RB
cord-258536-qnn9hp8e	93	17	involved	involve	VBN
cord-258536-qnn9hp8e	93	18	in	in	IN
cord-258536-qnn9hp8e	93	19	autophagy	autophagy	NN
cord-258536-qnn9hp8e	93	20	,	,	,
cord-258536-qnn9hp8e	93	21	but	but	CC
cord-258536-qnn9hp8e	93	22	recent	recent	JJ
cord-258536-qnn9hp8e	93	23	findings	finding	NNS
cord-258536-qnn9hp8e	93	24	have	have	VBP
cord-258536-qnn9hp8e	93	25	revealed	reveal	VBN
cord-258536-qnn9hp8e	93	26	that	that	IN
cord-258536-qnn9hp8e	93	27	single	single	JJ
cord-258536-qnn9hp8e	93	28	ATG	ATG	NNP
cord-258536-qnn9hp8e	93	29	genes	gene	NNS
cord-258536-qnn9hp8e	93	30	or	or	CC
cord-258536-qnn9hp8e	93	31	functional	functional	JJ
cord-258536-qnn9hp8e	93	32	clusters	cluster	NNS
cord-258536-qnn9hp8e	93	33	of	of	IN
cord-258536-qnn9hp8e	93	34	ATG	ATG	NNP
cord-258536-qnn9hp8e	93	35	genes	gene	NNS
cord-258536-qnn9hp8e	93	36	fulfill	fulfill	VBP
cord-258536-qnn9hp8e	93	37	important	important	JJ
cord-258536-qnn9hp8e	93	38	cellular	cellular	JJ
cord-258536-qnn9hp8e	93	39	functions	function	NNS
cord-258536-qnn9hp8e	93	40	outside	outside	IN
cord-258536-qnn9hp8e	93	41	the	the	DT
cord-258536-qnn9hp8e	93	42	context	context	NN
cord-258536-qnn9hp8e	93	43	of	of	IN
cord-258536-qnn9hp8e	93	44	their	-PRON-	PRP$
cord-258536-qnn9hp8e	93	45	role	role	NN
cord-258536-qnn9hp8e	93	46	in	in	IN
cord-258536-qnn9hp8e	93	47	autophagy	autophagy	NN
cord-258536-qnn9hp8e	93	48	[	[	-LRB-
cord-258536-qnn9hp8e	93	49	48	48	CD
cord-258536-qnn9hp8e	93	50	]	]	-RRB-
cord-258536-qnn9hp8e	94	1	[	[	-LRB-
cord-258536-qnn9hp8e	94	2	49	49	CD
cord-258536-qnn9hp8e	94	3	]	]	-RRB-
cord-258536-qnn9hp8e	94	4	[	[	-LRB-
cord-258536-qnn9hp8e	94	5	50	50	CD
cord-258536-qnn9hp8e	94	6	]	]	-RRB-
cord-258536-qnn9hp8e	94	7	.	.	.
cord-258536-qnn9hp8e	95	1	Some	some	DT
cord-258536-qnn9hp8e	95	2	of	of	IN
cord-258536-qnn9hp8e	95	3	these	these	DT
cord-258536-qnn9hp8e	95	4	functions	function	NNS
cord-258536-qnn9hp8e	95	5	have	have	VBP
cord-258536-qnn9hp8e	95	6	been	be	VBN
cord-258536-qnn9hp8e	95	7	discovered	discover	VBN
cord-258536-qnn9hp8e	95	8	by	by	IN
cord-258536-qnn9hp8e	95	9	studying	study	VBG
cord-258536-qnn9hp8e	95	10	host	host	NN
cord-258536-qnn9hp8e	95	11	-	-	HYPH
cord-258536-qnn9hp8e	95	12	pathogen	pathogen	NN
cord-258536-qnn9hp8e	95	13	interactions	interaction	NNS
cord-258536-qnn9hp8e	95	14	[	[	-LRB-
cord-258536-qnn9hp8e	95	15	48	48	CD
cord-258536-qnn9hp8e	95	16	,	,	,
cord-258536-qnn9hp8e	95	17	49	49	CD
cord-258536-qnn9hp8e	95	18	,	,	,
cord-258536-qnn9hp8e	95	19	51	51	CD
cord-258536-qnn9hp8e	95	20	]	]	-RRB-
cord-258536-qnn9hp8e	95	21	.	.	.
cord-258536-qnn9hp8e	96	1	For	for	IN
cord-258536-qnn9hp8e	96	2	example	example	NN
cord-258536-qnn9hp8e	96	3	,	,	,
cord-258536-qnn9hp8e	96	4	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	96	5	but	but	CC
cord-258536-qnn9hp8e	96	6	no	no	DT
cord-258536-qnn9hp8e	96	7	other	other	JJ
cord-258536-qnn9hp8e	96	8	ATG	ATG	NNP
cord-258536-qnn9hp8e	96	9	proteins	protein	NNS
cord-258536-qnn9hp8e	96	10	play	play	VBP
cord-258536-qnn9hp8e	96	11	a	a	DT
cord-258536-qnn9hp8e	96	12	unique	unique	JJ
cord-258536-qnn9hp8e	96	13	role	role	NN
cord-258536-qnn9hp8e	96	14	in	in	IN
cord-258536-qnn9hp8e	96	15	the	the	DT
cord-258536-qnn9hp8e	96	16	defense	defense	NN
cord-258536-qnn9hp8e	96	17	against	against	IN
cord-258536-qnn9hp8e	96	18	Mycobacterium	Mycobacterium	NNP
cord-258536-qnn9hp8e	96	19	infection	infection	NN
cord-258536-qnn9hp8e	96	20	[	[	-LRB-
cord-258536-qnn9hp8e	96	21	52	52	CD
cord-258536-qnn9hp8e	96	22	]	]	-RRB-
cord-258536-qnn9hp8e	96	23	.	.	.
cord-258536-qnn9hp8e	97	1	More	more	RBR
cord-258536-qnn9hp8e	97	2	recently	recently	RB
cord-258536-qnn9hp8e	97	3	,	,	,
cord-258536-qnn9hp8e	97	4	it	-PRON-	PRP
cord-258536-qnn9hp8e	97	5	has	have	VBZ
cord-258536-qnn9hp8e	97	6	been	be	VBN
cord-258536-qnn9hp8e	97	7	shown	show	VBN
cord-258536-qnn9hp8e	97	8	that	that	IN
cord-258536-qnn9hp8e	97	9	FIP200	FIP200	NNP
cord-258536-qnn9hp8e	97	10	and	and	CC
cord-258536-qnn9hp8e	97	11	ATG13	ATG13	NNP
cord-258536-qnn9hp8e	97	12	participate	participate	VBP
cord-258536-qnn9hp8e	97	13	in	in	IN
cord-258536-qnn9hp8e	97	14	the	the	DT
cord-258536-qnn9hp8e	97	15	controlling	controlling	NN
cord-258536-qnn9hp8e	97	16	of	of	IN
cord-258536-qnn9hp8e	97	17	picornaviral	picornaviral	JJ
cord-258536-qnn9hp8e	97	18	infections	infection	NNS
cord-258536-qnn9hp8e	97	19	outside	outside	IN
cord-258536-qnn9hp8e	97	20	the	the	DT
cord-258536-qnn9hp8e	97	21	context	context	NN
cord-258536-qnn9hp8e	97	22	of	of	IN
cord-258536-qnn9hp8e	97	23	autophagy	autophagy	NN
cord-258536-qnn9hp8e	97	24	[	[	-LRB-
cord-258536-qnn9hp8e	97	25	53	53	CD
cord-258536-qnn9hp8e	97	26	]	]	-RRB-
cord-258536-qnn9hp8e	97	27	.	.	.
cord-258536-qnn9hp8e	98	1	Here	here	RB
cord-258536-qnn9hp8e	98	2	,	,	,
cord-258536-qnn9hp8e	98	3	we	-PRON-	PRP
cord-258536-qnn9hp8e	98	4	will	will	MD
cord-258536-qnn9hp8e	98	5	review	review	VB
cord-258536-qnn9hp8e	98	6	the	the	DT
cord-258536-qnn9hp8e	98	7	current	current	JJ
cord-258536-qnn9hp8e	98	8	knowledge	knowledge	NN
cord-258536-qnn9hp8e	98	9	on	on	IN
cord-258536-qnn9hp8e	98	10	the	the	DT
cord-258536-qnn9hp8e	98	11	interplay	interplay	NN
cord-258536-qnn9hp8e	98	12	between	between	IN
cord-258536-qnn9hp8e	98	13	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	98	14	and	and	CC
cord-258536-qnn9hp8e	98	15	autophagy	autophagy	NN
cord-258536-qnn9hp8e	98	16	.	.	.
cord-258536-qnn9hp8e	99	1	There	there	EX
cord-258536-qnn9hp8e	99	2	are	be	VBP
cord-258536-qnn9hp8e	99	3	currently	currently	RB
cord-258536-qnn9hp8e	99	4	no	no	DT
cord-258536-qnn9hp8e	99	5	data	datum	NNS
cord-258536-qnn9hp8e	99	6	available	available	JJ
cord-258536-qnn9hp8e	99	7	for	for	IN
cord-258536-qnn9hp8e	99	8	several	several	JJ
cord-258536-qnn9hp8e	99	9	viruses	virus	NNS
cord-258536-qnn9hp8e	99	10	and	and	CC
cord-258536-qnn9hp8e	99	11	few	few	JJ
cord-258536-qnn9hp8e	99	12	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	99	13	families	family	NNS
cord-258536-qnn9hp8e	99	14	.	.	.
cord-258536-qnn9hp8e	100	1	Thus	thus	RB
cord-258536-qnn9hp8e	100	2	,	,	,
cord-258536-qnn9hp8e	100	3	this	this	DT
cord-258536-qnn9hp8e	100	4	compendium	compendium	NN
cord-258536-qnn9hp8e	100	5	will	will	MD
cord-258536-qnn9hp8e	100	6	focus	focus	VB
cord-258536-qnn9hp8e	100	7	on	on	IN
cord-258536-qnn9hp8e	100	8	the	the	DT
cord-258536-qnn9hp8e	100	9	documented	document	VBN
cord-258536-qnn9hp8e	100	10	viruses	virus	NNS
cord-258536-qnn9hp8e	100	11	in	in	IN
cord-258536-qnn9hp8e	100	12	the	the	DT
cord-258536-qnn9hp8e	100	13	Arterivirus	Arterivirus	NNP
cord-258536-qnn9hp8e	100	14	and	and	CC
cord-258536-qnn9hp8e	100	15	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	100	16	families	family	NNS
cord-258536-qnn9hp8e	100	17	(	(	-LRB-
cord-258536-qnn9hp8e	100	18	summarized	summarize	VBN
cord-258536-qnn9hp8e	100	19	in	in	IN
cord-258536-qnn9hp8e	100	20	Table	Table	NNP
cord-258536-qnn9hp8e	100	21	1	1	CD
cord-258536-qnn9hp8e	100	22	)	)	-RRB-
cord-258536-qnn9hp8e	100	23	.	.	.
cord-258536-qnn9hp8e	101	1	Green	green	JJ
cord-258536-qnn9hp8e	101	2	shading	shading	NN
cord-258536-qnn9hp8e	101	3	indicates	indicate	VBZ
cord-258536-qnn9hp8e	101	4	a	a	DT
cord-258536-qnn9hp8e	101	5	pro	pro	JJ
cord-258536-qnn9hp8e	101	6	-	-	JJ
cord-258536-qnn9hp8e	101	7	viral	viral	JJ
cord-258536-qnn9hp8e	101	8	role	role	NN
cord-258536-qnn9hp8e	101	9	for	for	IN
cord-258536-qnn9hp8e	101	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	101	11	,	,	,
cord-258536-qnn9hp8e	101	12	grey	grey	JJ
cord-258536-qnn9hp8e	101	13	shading	shading	NN
cord-258536-qnn9hp8e	101	14	indicates	indicate	VBZ
cord-258536-qnn9hp8e	101	15	conflictual	conflictual	JJ
cord-258536-qnn9hp8e	101	16	reports	report	NNS
cord-258536-qnn9hp8e	101	17	and	and	CC
cord-258536-qnn9hp8e	101	18	blue	blue	JJ
cord-258536-qnn9hp8e	101	19	shading	shading	NN
cord-258536-qnn9hp8e	101	20	highlights	highlight	VBZ
cord-258536-qnn9hp8e	101	21	an	an	DT
cord-258536-qnn9hp8e	101	22	unconventional	unconventional	JJ
cord-258536-qnn9hp8e	101	23	role	role	NN
cord-258536-qnn9hp8e	101	24	of	of	IN
cord-258536-qnn9hp8e	101	25	autophagy	autophagy	NN
cord-258536-qnn9hp8e	101	26	-	-	HYPH
cord-258536-qnn9hp8e	101	27	related	relate	VBN
cord-258536-qnn9hp8e	101	28	(	(	-LRB-
cord-258536-qnn9hp8e	101	29	ATG	ATG	NNP
cord-258536-qnn9hp8e	101	30	)	)	-RRB-
cord-258536-qnn9hp8e	101	31	proteins	protein	NNS
cord-258536-qnn9hp8e	101	32	.	.	.
cord-258536-qnn9hp8e	102	1	The	the	DT
cord-258536-qnn9hp8e	102	2	table	table	NN
cord-258536-qnn9hp8e	102	3	also	also	RB
cord-258536-qnn9hp8e	102	4	provides	provide	VBZ
cord-258536-qnn9hp8e	102	5	the	the	DT
cord-258536-qnn9hp8e	102	6	information	information	NN
cord-258536-qnn9hp8e	102	7	about	about	IN
cord-258536-qnn9hp8e	102	8	how	how	WRB
cord-258536-qnn9hp8e	102	9	autophagy	autophagy	NN
cord-258536-qnn9hp8e	102	10	has	have	VBZ
cord-258536-qnn9hp8e	102	11	been	be	VBN
cord-258536-qnn9hp8e	102	12	experimentally	experimentally	RB
cord-258536-qnn9hp8e	102	13	manipulated	manipulate	VBN
cord-258536-qnn9hp8e	102	14	in	in	IN
cord-258536-qnn9hp8e	102	15	the	the	DT
cord-258536-qnn9hp8e	102	16	studies	study	NNS
cord-258536-qnn9hp8e	102	17	addressing	address	VBG
cord-258536-qnn9hp8e	102	18	the	the	DT
cord-258536-qnn9hp8e	102	19	role	role	NN
cord-258536-qnn9hp8e	102	20	of	of	IN
cord-258536-qnn9hp8e	102	21	this	this	DT
cord-258536-qnn9hp8e	102	22	pathway	pathway	NN
cord-258536-qnn9hp8e	102	23	with	with	IN
cord-258536-qnn9hp8e	102	24	the	the	DT
cord-258536-qnn9hp8e	102	25	indicated	indicate	VBN
cord-258536-qnn9hp8e	102	26	virus	virus	NN
cord-258536-qnn9hp8e	102	27	,	,	,
cord-258536-qnn9hp8e	102	28	the	the	DT
cord-258536-qnn9hp8e	102	29	used	use	VBN
cord-258536-qnn9hp8e	102	30	cell	cell	NN
cord-258536-qnn9hp8e	102	31	types	type	NNS
cord-258536-qnn9hp8e	102	32	,	,	,
cord-258536-qnn9hp8e	102	33	and	and	CC
cord-258536-qnn9hp8e	102	34	the	the	DT
cord-258536-qnn9hp8e	102	35	references	reference	NNS
cord-258536-qnn9hp8e	102	36	.	.	.
cord-258536-qnn9hp8e	103	1	3-MA	3-ma	LS
cord-258536-qnn9hp8e	103	2	:	:	:
cord-258536-qnn9hp8e	103	3	3-methyladenine	3-methyladenine	CD
cord-258536-qnn9hp8e	103	4	;	;	:
cord-258536-qnn9hp8e	103	5	BafA	BafA	NNP
cord-258536-qnn9hp8e	103	6	1	1	CD
cord-258536-qnn9hp8e	103	7	:	:	:
cord-258536-qnn9hp8e	103	8	bafilomycin	bafilomycin	NNP
cord-258536-qnn9hp8e	104	1	A	a	DT
cord-258536-qnn9hp8e	104	2	1	1	CD
cord-258536-qnn9hp8e	105	1	,	,	,
cord-258536-qnn9hp8e	105	2	LC3	LC3	NNP
cord-258536-qnn9hp8e	105	3	:	:	:
cord-258536-qnn9hp8e	105	4	microtubule	microtubule	NN
cord-258536-qnn9hp8e	105	5	-	-	HYPH
cord-258536-qnn9hp8e	105	6	associated	associate	VBN
cord-258536-qnn9hp8e	105	7	protein	protein	NN
cord-258536-qnn9hp8e	105	8	light	light	NN
cord-258536-qnn9hp8e	105	9	chain	chain	NN
cord-258536-qnn9hp8e	105	10	3	3	CD
cord-258536-qnn9hp8e	105	11	,	,	,
cord-258536-qnn9hp8e	105	12	MEFs	mef	NNS
cord-258536-qnn9hp8e	105	13	:	:	:
cord-258536-qnn9hp8e	105	14	mouse	mouse	NN
cord-258536-qnn9hp8e	105	15	embryonic	embryonic	JJ
cord-258536-qnn9hp8e	105	16	fibroblasts	fibroblast	NNS
cord-258536-qnn9hp8e	105	17	.	.	.
cord-258536-qnn9hp8e	106	1	The	the	DT
cord-258536-qnn9hp8e	106	2	two	two	CD
cord-258536-qnn9hp8e	106	3	most	most	RBS
cord-258536-qnn9hp8e	106	4	studied	study	VBN
cord-258536-qnn9hp8e	106	5	Arteriviridae	Arteriviridae	NNP
cord-258536-qnn9hp8e	106	6	are	be	VBP
cord-258536-qnn9hp8e	106	7	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	106	8	and	and	CC
cord-258536-qnn9hp8e	106	9	the	the	DT
cord-258536-qnn9hp8e	106	10	equine	equine	JJ
cord-258536-qnn9hp8e	106	11	arteritis	arteritis	NN
cord-258536-qnn9hp8e	106	12	virus	virus	NN
cord-258536-qnn9hp8e	106	13	(	(	-LRB-
cord-258536-qnn9hp8e	106	14	EAV	EAV	NNP
cord-258536-qnn9hp8e	106	15	)	)	-RRB-
cord-258536-qnn9hp8e	106	16	.	.	.
cord-258536-qnn9hp8e	107	1	The	the	DT
cord-258536-qnn9hp8e	107	2	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	107	3	strain	strain	NN
cord-258536-qnn9hp8e	107	4	,	,	,
cord-258536-qnn9hp8e	107	5	which	which	WDT
cord-258536-qnn9hp8e	107	6	was	be	VBD
cord-258536-qnn9hp8e	107	7	historically	historically	RB
cord-258536-qnn9hp8e	107	8	first	first	RB
cord-258536-qnn9hp8e	107	9	characterized	characterize	VBN
cord-258536-qnn9hp8e	107	10	and	and	CC
cord-258536-qnn9hp8e	107	11	is	be	VBZ
cord-258536-qnn9hp8e	107	12	commonly	commonly	RB
cord-258536-qnn9hp8e	107	13	referred	refer	VBN
cord-258536-qnn9hp8e	107	14	to	to	IN
cord-258536-qnn9hp8e	107	15	as	as	RB
cord-258536-qnn9hp8e	107	16	atypical	atypical	JJ
cord-258536-qnn9hp8e	107	17	(	(	-LRB-
cord-258536-qnn9hp8e	107	18	i.e.	i.e.	FW
cord-258536-qnn9hp8e	107	19	,	,	,
cord-258536-qnn9hp8e	107	20	AP	AP	NNP
cord-258536-qnn9hp8e	107	21	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	107	22	)	)	-RRB-
cord-258536-qnn9hp8e	107	23	,	,	,
cord-258536-qnn9hp8e	107	24	causes	cause	VBZ
cord-258536-qnn9hp8e	107	25	the	the	DT
cord-258536-qnn9hp8e	107	26	abortions	abortion	NNS
cord-258536-qnn9hp8e	107	27	in	in	IN
cord-258536-qnn9hp8e	107	28	10	10	CD
cord-258536-qnn9hp8e	107	29	-	-	SYM
cord-258536-qnn9hp8e	107	30	50	50	CD
cord-258536-qnn9hp8e	107	31	%	%	NN
cord-258536-qnn9hp8e	107	32	of	of	IN
cord-258536-qnn9hp8e	107	33	the	the	DT
cord-258536-qnn9hp8e	107	34	sows	sow	NNS
cord-258536-qnn9hp8e	107	35	,	,	,
cord-258536-qnn9hp8e	107	36	and	and	CC
cord-258536-qnn9hp8e	107	37	fever	fever	NN
cord-258536-qnn9hp8e	107	38	and	and	CC
cord-258536-qnn9hp8e	107	39	anorexia	anorexia	NN
cord-258536-qnn9hp8e	107	40	leading	lead	VBG
cord-258536-qnn9hp8e	107	41	to	to	IN
cord-258536-qnn9hp8e	107	42	the	the	DT
cord-258536-qnn9hp8e	107	43	death	death	NN
cord-258536-qnn9hp8e	107	44	of	of	IN
cord-258536-qnn9hp8e	107	45	5	5	CD
cord-258536-qnn9hp8e	107	46	-	-	SYM
cord-258536-qnn9hp8e	107	47	10	10	CD
cord-258536-qnn9hp8e	107	48	%	%	NN
cord-258536-qnn9hp8e	107	49	of	of	IN
cord-258536-qnn9hp8e	107	50	them	-PRON-	PRP
cord-258536-qnn9hp8e	107	51	[	[	-LRB-
cord-258536-qnn9hp8e	107	52	69	69	CD
cord-258536-qnn9hp8e	107	53	]	]	-RRB-
cord-258536-qnn9hp8e	107	54	.	.	.
cord-258536-qnn9hp8e	108	1	However	however	RB
cord-258536-qnn9hp8e	108	2	,	,	,
cord-258536-qnn9hp8e	108	3	in	in	IN
cord-258536-qnn9hp8e	108	4	2006	2006	CD
cord-258536-qnn9hp8e	108	5	,	,	,
cord-258536-qnn9hp8e	108	6	the	the	DT
cord-258536-qnn9hp8e	108	7	emergence	emergence	NN
cord-258536-qnn9hp8e	108	8	of	of	IN
cord-258536-qnn9hp8e	108	9	a	a	DT
cord-258536-qnn9hp8e	108	10	novel	novel	JJ
cord-258536-qnn9hp8e	108	11	virulent	virulent	NN
cord-258536-qnn9hp8e	108	12	highly	highly	RB
cord-258536-qnn9hp8e	108	13	pathogenic	pathogenic	JJ
cord-258536-qnn9hp8e	108	14	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	108	15	(	(	-LRB-
cord-258536-qnn9hp8e	108	16	HP	HP	NNP
cord-258536-qnn9hp8e	108	17	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	108	18	)	)	-RRB-
cord-258536-qnn9hp8e	108	19	strain	strain	NN
cord-258536-qnn9hp8e	108	20	,	,	,
cord-258536-qnn9hp8e	108	21	carrying	carry	VBG
cord-258536-qnn9hp8e	108	22	mutations	mutation	NNS
cord-258536-qnn9hp8e	108	23	in	in	IN
cord-258536-qnn9hp8e	108	24	nsp1β	nsp1β	NN
cord-258536-qnn9hp8e	108	25	,	,	,
cord-258536-qnn9hp8e	108	26	nsp2	nsp2	NNP
cord-258536-qnn9hp8e	108	27	,	,	,
cord-258536-qnn9hp8e	108	28	and	and	CC
cord-258536-qnn9hp8e	108	29	ORF5	ORF5	NNP
cord-258536-qnn9hp8e	108	30	genes	gene	NNS
cord-258536-qnn9hp8e	108	31	,	,	,
cord-258536-qnn9hp8e	108	32	caused	cause	VBD
cord-258536-qnn9hp8e	108	33	higher	high	JJR
cord-258536-qnn9hp8e	108	34	morbidity	morbidity	NN
cord-258536-qnn9hp8e	108	35	(	(	-LRB-
cord-258536-qnn9hp8e	108	36	50	50	CD
cord-258536-qnn9hp8e	108	37	%	%	NN
cord-258536-qnn9hp8e	108	38	)	)	-RRB-
cord-258536-qnn9hp8e	108	39	and	and	CC
cord-258536-qnn9hp8e	108	40	mortality	mortality	NN
cord-258536-qnn9hp8e	108	41	(	(	-LRB-
cord-258536-qnn9hp8e	108	42	20	20	CD
cord-258536-qnn9hp8e	108	43	%	%	NN
cord-258536-qnn9hp8e	108	44	)	)	-RRB-
cord-258536-qnn9hp8e	108	45	rates	rate	NNS
cord-258536-qnn9hp8e	108	46	in	in	IN
cord-258536-qnn9hp8e	108	47	piglets	piglet	NNS
cord-258536-qnn9hp8e	108	48	and	and	CC
cord-258536-qnn9hp8e	108	49	sows	sow	NNS
cord-258536-qnn9hp8e	108	50	[	[	-LRB-
cord-258536-qnn9hp8e	108	51	70	70	CD
cord-258536-qnn9hp8e	108	52	]	]	-RRB-
cord-258536-qnn9hp8e	108	53	.	.	.
cord-258536-qnn9hp8e	109	1	The	the	DT
cord-258536-qnn9hp8e	109	2	equine	equine	JJ
cord-258536-qnn9hp8e	109	3	arteritis	arteritis	NN
cord-258536-qnn9hp8e	109	4	virus	virus	NN
cord-258536-qnn9hp8e	109	5	,	,	,
cord-258536-qnn9hp8e	109	6	in	in	IN
cord-258536-qnn9hp8e	109	7	contrast	contrast	NN
cord-258536-qnn9hp8e	109	8	,	,	,
cord-258536-qnn9hp8e	109	9	infects	infect	VBZ
cord-258536-qnn9hp8e	109	10	horses	horse	NNS
cord-258536-qnn9hp8e	109	11	and	and	CC
cord-258536-qnn9hp8e	109	12	donkeys	donkey	NNS
cord-258536-qnn9hp8e	109	13	,	,	,
cord-258536-qnn9hp8e	109	14	and	and	CC
cord-258536-qnn9hp8e	109	15	can	can	MD
cord-258536-qnn9hp8e	109	16	cause	cause	VB
cord-258536-qnn9hp8e	109	17	abortions	abortion	NNS
cord-258536-qnn9hp8e	109	18	in	in	IN
cord-258536-qnn9hp8e	109	19	pregnant	pregnant	JJ
cord-258536-qnn9hp8e	109	20	females	female	NNS
cord-258536-qnn9hp8e	109	21	and	and	CC
cord-258536-qnn9hp8e	109	22	mortality	mortality	NN
cord-258536-qnn9hp8e	109	23	in	in	IN
cord-258536-qnn9hp8e	109	24	neonates	neonate	NNS
cord-258536-qnn9hp8e	109	25	[	[	-LRB-
cord-258536-qnn9hp8e	109	26	71	71	CD
cord-258536-qnn9hp8e	109	27	]	]	-RRB-
cord-258536-qnn9hp8e	109	28	.	.	.
cord-258536-qnn9hp8e	110	1	The	the	DT
cord-258536-qnn9hp8e	110	2	first	first	JJ
cord-258536-qnn9hp8e	110	3	study	study	NN
cord-258536-qnn9hp8e	110	4	on	on	IN
cord-258536-qnn9hp8e	110	5	the	the	DT
cord-258536-qnn9hp8e	110	6	role	role	NN
cord-258536-qnn9hp8e	110	7	of	of	IN
cord-258536-qnn9hp8e	110	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	110	9	in	in	IN
cord-258536-qnn9hp8e	110	10	Arterivirus	Arterivirus	NNP
cord-258536-qnn9hp8e	110	11	life	life	NN
cord-258536-qnn9hp8e	110	12	cycle	cycle	NN
cord-258536-qnn9hp8e	110	13	was	be	VBD
cord-258536-qnn9hp8e	110	14	carried	carry	VBN
cord-258536-qnn9hp8e	110	15	out	out	RP
cord-258536-qnn9hp8e	110	16	with	with	IN
cord-258536-qnn9hp8e	110	17	the	the	DT
cord-258536-qnn9hp8e	110	18	HP	HP	NNP
cord-258536-qnn9hp8e	110	19	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	110	20	strain	strain	VBP
cord-258536-qnn9hp8e	110	21	[	[	-LRB-
cord-258536-qnn9hp8e	110	22	57	57	CD
cord-258536-qnn9hp8e	110	23	]	]	-RRB-
cord-258536-qnn9hp8e	110	24	.	.	.
cord-258536-qnn9hp8e	111	1	Infected	infected	JJ
cord-258536-qnn9hp8e	111	2	cells	cell	NNS
cord-258536-qnn9hp8e	111	3	displayed	display	VBD
cord-258536-qnn9hp8e	111	4	the	the	DT
cord-258536-qnn9hp8e	111	5	presence	presence	NN
cord-258536-qnn9hp8e	111	6	of	of	IN
cord-258536-qnn9hp8e	111	7	a	a	DT
cord-258536-qnn9hp8e	111	8	higher	high	JJR
cord-258536-qnn9hp8e	111	9	number	number	NN
cord-258536-qnn9hp8e	111	10	of	of	IN
cord-258536-qnn9hp8e	111	11	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	111	12	-	-	HYPH
cord-258536-qnn9hp8e	111	13	like	like	JJ
cord-258536-qnn9hp8e	111	14	double	double	JJ
cord-258536-qnn9hp8e	111	15	-	-	HYPH
cord-258536-qnn9hp8e	111	16	membrane	membrane	NN
cord-258536-qnn9hp8e	111	17	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	111	18	,	,	,
cord-258536-qnn9hp8e	111	19	an	an	DT
cord-258536-qnn9hp8e	111	20	accumulation	accumulation	NN
cord-258536-qnn9hp8e	111	21	of	of	IN
cord-258536-qnn9hp8e	111	22	green	green	JJ
cord-258536-qnn9hp8e	111	23	fluorescent	fluorescent	NN
cord-258536-qnn9hp8e	111	24	protein	protein	NN
cord-258536-qnn9hp8e	111	25	(	(	-LRB-
cord-258536-qnn9hp8e	111	26	GFP)-LC3-positive	gfp)-lc3-positive	CD
cord-258536-qnn9hp8e	111	27	puncta	puncta	NN
cord-258536-qnn9hp8e	111	28	and	and	CC
cord-258536-qnn9hp8e	111	29	higher	high	JJR
cord-258536-qnn9hp8e	111	30	levels	level	NNS
cord-258536-qnn9hp8e	111	31	of	of	IN
cord-258536-qnn9hp8e	111	32	lipidated	lipidate	VBN
cord-258536-qnn9hp8e	111	33	LC3	LC3	NNP
cord-258536-qnn9hp8e	111	34	,	,	,
cord-258536-qnn9hp8e	111	35	indicating	indicate	VBG
cord-258536-qnn9hp8e	111	36	an	an	DT
cord-258536-qnn9hp8e	111	37	induction	induction	NN
cord-258536-qnn9hp8e	111	38	of	of	IN
cord-258536-qnn9hp8e	111	39	autophagy	autophagy	NN
cord-258536-qnn9hp8e	111	40	[	[	-LRB-
cord-258536-qnn9hp8e	111	41	57	57	CD
cord-258536-qnn9hp8e	111	42	]	]	-RRB-
cord-258536-qnn9hp8e	111	43	.	.	.
cord-258536-qnn9hp8e	112	1	Inhibition	inhibition	NN
cord-258536-qnn9hp8e	112	2	of	of	IN
cord-258536-qnn9hp8e	112	3	autophagy	autophagy	NN
cord-258536-qnn9hp8e	112	4	with	with	IN
cord-258536-qnn9hp8e	112	5	either	either	DT
cord-258536-qnn9hp8e	112	6	3-methyladenine	3-methyladenine	CD
cord-258536-qnn9hp8e	112	7	(	(	-LRB-
cord-258536-qnn9hp8e	112	8	3-MA	3-ma	CD
cord-258536-qnn9hp8e	112	9	)	)	-RRB-
cord-258536-qnn9hp8e	112	10	,	,	,
cord-258536-qnn9hp8e	112	11	a	a	DT
cord-258536-qnn9hp8e	112	12	non	non	JJ
cord-258536-qnn9hp8e	112	13	-	-	JJ
cord-258536-qnn9hp8e	112	14	specific	specific	JJ
cord-258536-qnn9hp8e	112	15	hVPS34	hVPS34	NNP
cord-258536-qnn9hp8e	112	16	inhibitor	inhibitor	NN
cord-258536-qnn9hp8e	112	17	,	,	,
cord-258536-qnn9hp8e	112	18	or	or	CC
cord-258536-qnn9hp8e	112	19	depletion	depletion	NN
cord-258536-qnn9hp8e	112	20	of	of	IN
cord-258536-qnn9hp8e	112	21	ATG7	ATG7	NNP
cord-258536-qnn9hp8e	112	22	or	or	CC
cord-258536-qnn9hp8e	112	23	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	112	24	,	,	,
cord-258536-qnn9hp8e	112	25	led	lead	VBD
cord-258536-qnn9hp8e	112	26	to	to	IN
cord-258536-qnn9hp8e	112	27	a	a	DT
cord-258536-qnn9hp8e	112	28	significant	significant	JJ
cord-258536-qnn9hp8e	112	29	reduction	reduction	NN
cord-258536-qnn9hp8e	112	30	in	in	IN
cord-258536-qnn9hp8e	112	31	both	both	DT
cord-258536-qnn9hp8e	112	32	expression	expression	NN
cord-258536-qnn9hp8e	112	33	of	of	IN
cord-258536-qnn9hp8e	112	34	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	112	35	nsp2	nsp2	NNP
cord-258536-qnn9hp8e	112	36	and	and	CC
cord-258536-qnn9hp8e	112	37	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	112	38	titer	titer	NN
cord-258536-qnn9hp8e	112	39	.	.	.
cord-258536-qnn9hp8e	113	1	Conversely	conversely	RB
cord-258536-qnn9hp8e	113	2	,	,	,
cord-258536-qnn9hp8e	113	3	induction	induction	NN
cord-258536-qnn9hp8e	113	4	of	of	IN
cord-258536-qnn9hp8e	113	5	bulk	bulk	JJ
cord-258536-qnn9hp8e	113	6	autophagy	autophagy	NN
cord-258536-qnn9hp8e	113	7	using	use	VBG
cord-258536-qnn9hp8e	113	8	rapamycin	rapamycin	VBN
cord-258536-qnn9hp8e	113	9	(	(	-LRB-
cord-258536-qnn9hp8e	113	10	mTOR	mTOR	NNP
cord-258536-qnn9hp8e	113	11	inhibitor	inhibitor	NN
cord-258536-qnn9hp8e	113	12	)	)	-RRB-
cord-258536-qnn9hp8e	113	13	resulted	result	VBD
cord-258536-qnn9hp8e	113	14	in	in	IN
cord-258536-qnn9hp8e	113	15	an	an	DT
cord-258536-qnn9hp8e	113	16	enhancement	enhancement	NN
cord-258536-qnn9hp8e	113	17	of	of	IN
cord-258536-qnn9hp8e	113	18	viral	viral	JJ
cord-258536-qnn9hp8e	113	19	replication	replication	NN
cord-258536-qnn9hp8e	113	20	[	[	-LRB-
cord-258536-qnn9hp8e	113	21	57	57	CD
cord-258536-qnn9hp8e	113	22	]	]	-RRB-
cord-258536-qnn9hp8e	113	23	,	,	,
cord-258536-qnn9hp8e	113	24	a	a	DT
cord-258536-qnn9hp8e	113	25	result	result	NN
cord-258536-qnn9hp8e	113	26	that	that	IN
cord-258536-qnn9hp8e	113	27	later	later	RB
cord-258536-qnn9hp8e	113	28	was	be	VBD
cord-258536-qnn9hp8e	113	29	confirmed	confirm	VBN
cord-258536-qnn9hp8e	113	30	by	by	IN
cord-258536-qnn9hp8e	113	31	others	other	NNS
cord-258536-qnn9hp8e	113	32	[	[	-LRB-
cord-258536-qnn9hp8e	113	33	57	57	CD
cord-258536-qnn9hp8e	113	34	]	]	-RRB-
cord-258536-qnn9hp8e	113	35	[	[	-LRB-
cord-258536-qnn9hp8e	113	36	58	58	CD
cord-258536-qnn9hp8e	113	37	]	]	-RRB-
cord-258536-qnn9hp8e	113	38	[	[	-LRB-
cord-258536-qnn9hp8e	113	39	59	59	CD
cord-258536-qnn9hp8e	113	40	]	]	-RRB-
cord-258536-qnn9hp8e	113	41	[	[	-LRB-
cord-258536-qnn9hp8e	113	42	60	60	CD
cord-258536-qnn9hp8e	113	43	]	]	-RRB-
cord-258536-qnn9hp8e	113	44	.	.	.
cord-258536-qnn9hp8e	114	1	In	in	IN
cord-258536-qnn9hp8e	114	2	one	one	CD
cord-258536-qnn9hp8e	114	3	of	of	IN
cord-258536-qnn9hp8e	114	4	these	these	DT
cord-258536-qnn9hp8e	114	5	subsequent	subsequent	JJ
cord-258536-qnn9hp8e	114	6	studies	study	NNS
cord-258536-qnn9hp8e	114	7	,	,	,
cord-258536-qnn9hp8e	114	8	Pujhari	Pujhari	NNP
cord-258536-qnn9hp8e	114	9	et	et	FW
cord-258536-qnn9hp8e	114	10	al	al	NNP
cord-258536-qnn9hp8e	114	11	.	.	NNP
cord-258536-qnn9hp8e	114	12	showed	show	VBD
cord-258536-qnn9hp8e	114	13	that	that	IN
cord-258536-qnn9hp8e	114	14	while	while	IN
cord-258536-qnn9hp8e	114	15	the	the	DT
cord-258536-qnn9hp8e	114	16	virus	virus	NN
cord-258536-qnn9hp8e	114	17	titer	titer	NN
cord-258536-qnn9hp8e	114	18	in	in	IN
cord-258536-qnn9hp8e	114	19	the	the	DT
cord-258536-qnn9hp8e	114	20	supernatants	supernatant	NNS
cord-258536-qnn9hp8e	114	21	of	of	IN
cord-258536-qnn9hp8e	114	22	infected	infected	JJ
cord-258536-qnn9hp8e	114	23	cells	cell	NNS
cord-258536-qnn9hp8e	114	24	treated	treat	VBN
cord-258536-qnn9hp8e	114	25	with	with	IN
cord-258536-qnn9hp8e	114	26	rapamycin	rapamycin	NNS
cord-258536-qnn9hp8e	114	27	was	be	VBD
cord-258536-qnn9hp8e	114	28	higher	high	JJR
cord-258536-qnn9hp8e	114	29	than	than	IN
cord-258536-qnn9hp8e	114	30	in	in	IN
cord-258536-qnn9hp8e	114	31	the	the	DT
cord-258536-qnn9hp8e	114	32	control	control	NN
cord-258536-qnn9hp8e	114	33	,	,	,
cord-258536-qnn9hp8e	114	34	intracellular	intracellular	JJ
cord-258536-qnn9hp8e	114	35	levels	level	NNS
cord-258536-qnn9hp8e	114	36	of	of	IN
cord-258536-qnn9hp8e	114	37	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	114	38	N	N	NNP
cord-258536-qnn9hp8e	114	39	protein	protein	NN
cord-258536-qnn9hp8e	114	40	or	or	CC
cord-258536-qnn9hp8e	114	41	nsp2	nsp2	NN
cord-258536-qnn9hp8e	114	42	assessed	assess	VBN
cord-258536-qnn9hp8e	114	43	by	by	IN
cord-258536-qnn9hp8e	114	44	flow	flow	NN
cord-258536-qnn9hp8e	114	45	cytometry	cytometry	NN
cord-258536-qnn9hp8e	114	46	were	be	VBD
cord-258536-qnn9hp8e	114	47	lower	low	JJR
cord-258536-qnn9hp8e	114	48	[	[	-LRB-
cord-258536-qnn9hp8e	114	49	58	58	CD
cord-258536-qnn9hp8e	114	50	]	]	-RRB-
cord-258536-qnn9hp8e	114	51	.	.	.
cord-258536-qnn9hp8e	115	1	This	this	DT
cord-258536-qnn9hp8e	115	2	latter	latter	JJ
cord-258536-qnn9hp8e	115	3	result	result	NN
cord-258536-qnn9hp8e	115	4	is	be	VBZ
cord-258536-qnn9hp8e	115	5	the	the	DT
cord-258536-qnn9hp8e	115	6	opposite	opposite	NN
cord-258536-qnn9hp8e	115	7	of	of	IN
cord-258536-qnn9hp8e	115	8	the	the	DT
cord-258536-qnn9hp8e	115	9	ones	one	NNS
cord-258536-qnn9hp8e	115	10	obtained	obtain	VBN
cord-258536-qnn9hp8e	115	11	by	by	IN
cord-258536-qnn9hp8e	115	12	the	the	DT
cord-258536-qnn9hp8e	115	13	other	other	JJ
cord-258536-qnn9hp8e	115	14	studies	study	NNS
cord-258536-qnn9hp8e	115	15	where	where	WRB
cord-258536-qnn9hp8e	115	16	rapamycin	rapamycin	NN
cord-258536-qnn9hp8e	115	17	treatment	treatment	NN
cord-258536-qnn9hp8e	115	18	led	lead	VBD
cord-258536-qnn9hp8e	115	19	to	to	IN
cord-258536-qnn9hp8e	115	20	an	an	DT
cord-258536-qnn9hp8e	115	21	up	up	JJ
cord-258536-qnn9hp8e	115	22	-	-	HYPH
cord-258536-qnn9hp8e	115	23	regulation	regulation	NN
cord-258536-qnn9hp8e	115	24	of	of	IN
cord-258536-qnn9hp8e	115	25	nsp2	nsp2	NN
cord-258536-qnn9hp8e	115	26	expression	expression	NN
cord-258536-qnn9hp8e	115	27	[	[	-LRB-
cord-258536-qnn9hp8e	115	28	57	57	CD
cord-258536-qnn9hp8e	115	29	]	]	-RRB-
cord-258536-qnn9hp8e	115	30	[	[	-LRB-
cord-258536-qnn9hp8e	115	31	58	58	CD
cord-258536-qnn9hp8e	115	32	]	]	-RRB-
cord-258536-qnn9hp8e	115	33	[	[	-LRB-
cord-258536-qnn9hp8e	115	34	59	59	CD
cord-258536-qnn9hp8e	115	35	]	]	-RRB-
cord-258536-qnn9hp8e	115	36	[	[	-LRB-
cord-258536-qnn9hp8e	115	37	60	60	CD
cord-258536-qnn9hp8e	115	38	]	]	-RRB-
cord-258536-qnn9hp8e	115	39	.	.	.
cord-258536-qnn9hp8e	116	1	Two	two	CD
cord-258536-qnn9hp8e	116	2	subsequent	subsequent	JJ
cord-258536-qnn9hp8e	116	3	works	work	NNS
cord-258536-qnn9hp8e	116	4	reached	reach	VBD
cord-258536-qnn9hp8e	116	5	the	the	DT
cord-258536-qnn9hp8e	116	6	same	same	JJ
cord-258536-qnn9hp8e	116	7	conclusion	conclusion	NN
cord-258536-qnn9hp8e	116	8	of	of	IN
cord-258536-qnn9hp8e	116	9	autophagy	autophagy	NN
cord-258536-qnn9hp8e	116	10	having	have	VBG
cord-258536-qnn9hp8e	116	11	a	a	DT
cord-258536-qnn9hp8e	116	12	beneficial	beneficial	JJ
cord-258536-qnn9hp8e	116	13	role	role	NN
cord-258536-qnn9hp8e	116	14	in	in	IN
cord-258536-qnn9hp8e	116	15	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	116	16	life	life	NN
cord-258536-qnn9hp8e	116	17	cycle	cycle	NN
cord-258536-qnn9hp8e	116	18	[	[	-LRB-
cord-258536-qnn9hp8e	116	19	59	59	CD
cord-258536-qnn9hp8e	116	20	,	,	,
cord-258536-qnn9hp8e	116	21	60	60	CD
cord-258536-qnn9hp8e	116	22	]	]	-RRB-
cord-258536-qnn9hp8e	116	23	.	.	.
cord-258536-qnn9hp8e	117	1	Liu	Liu	NNP
cord-258536-qnn9hp8e	117	2	et	et	NNP
cord-258536-qnn9hp8e	117	3	al	al	NNP
cord-258536-qnn9hp8e	117	4	.	.	.
cord-258536-qnn9hp8e	118	1	confirmed	confirm	VBD
cord-258536-qnn9hp8e	118	2	autophagy	autophagy	NN
cord-258536-qnn9hp8e	118	3	induction	induction	NN
cord-258536-qnn9hp8e	118	4	by	by	IN
cord-258536-qnn9hp8e	118	5	both	both	DT
cord-258536-qnn9hp8e	118	6	AP	AP	NNP
cord-258536-qnn9hp8e	118	7	and	and	CC
cord-258536-qnn9hp8e	118	8	HP	HP	NNP
cord-258536-qnn9hp8e	118	9	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	118	10	strains	strain	VBZ
cord-258536-qnn9hp8e	118	11	[	[	-LRB-
cord-258536-qnn9hp8e	118	12	59	59	CD
cord-258536-qnn9hp8e	118	13	]	]	-RRB-
cord-258536-qnn9hp8e	118	14	.	.	.
cord-258536-qnn9hp8e	119	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	119	2	,	,	,
cord-258536-qnn9hp8e	119	3	they	-PRON-	PRP
cord-258536-qnn9hp8e	119	4	also	also	RB
cord-258536-qnn9hp8e	119	5	observed	observe	VBD
cord-258536-qnn9hp8e	119	6	a	a	DT
cord-258536-qnn9hp8e	119	7	decrease	decrease	NN
cord-258536-qnn9hp8e	119	8	in	in	IN
cord-258536-qnn9hp8e	119	9	the	the	DT
cord-258536-qnn9hp8e	119	10	virus	virus	NN
cord-258536-qnn9hp8e	119	11	titer	titer	NN
cord-258536-qnn9hp8e	119	12	in	in	IN
cord-258536-qnn9hp8e	119	13	cells	cell	NNS
cord-258536-qnn9hp8e	119	14	treated	treat	VBN
cord-258536-qnn9hp8e	119	15	with	with	IN
cord-258536-qnn9hp8e	119	16	bafilomycin	bafilomycin	NNS
cord-258536-qnn9hp8e	119	17	A	A	NNP
cord-258536-qnn9hp8e	119	18	1	1	CD
cord-258536-qnn9hp8e	119	19	(	(	-LRB-
cord-258536-qnn9hp8e	119	20	BafA1	BafA1	NNP
cord-258536-qnn9hp8e	119	21	)	)	-RRB-
cord-258536-qnn9hp8e	119	22	,	,	,
cord-258536-qnn9hp8e	119	23	a	a	DT
cord-258536-qnn9hp8e	119	24	drug	drug	NN
cord-258536-qnn9hp8e	119	25	inhibiting	inhibit	VBG
cord-258536-qnn9hp8e	119	26	either	either	CC
cord-258536-qnn9hp8e	119	27	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	119	28	-	-	HYPH
cord-258536-qnn9hp8e	119	29	lysosome	lysosome	NN
cord-258536-qnn9hp8e	119	30	fusion	fusion	NN
cord-258536-qnn9hp8e	119	31	or	or	CC
cord-258536-qnn9hp8e	119	32	lysosomal	lysosomal	JJ
cord-258536-qnn9hp8e	119	33	degradation	degradation	NN
cord-258536-qnn9hp8e	119	34	,	,	,
cord-258536-qnn9hp8e	119	35	which	which	WDT
cord-258536-qnn9hp8e	119	36	suggested	suggest	VBD
cord-258536-qnn9hp8e	119	37	that	that	IN
cord-258536-qnn9hp8e	119	38	autolysosomes	autolysosomes	NNP
cord-258536-qnn9hp8e	119	39	might	may	MD
cord-258536-qnn9hp8e	119	40	serve	serve	VB
cord-258536-qnn9hp8e	119	41	as	as	IN
cord-258536-qnn9hp8e	119	42	replication	replication	NN
cord-258536-qnn9hp8e	119	43	platforms	platform	NNS
cord-258536-qnn9hp8e	119	44	for	for	IN
cord-258536-qnn9hp8e	119	45	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	119	46	[	[	-LRB-
cord-258536-qnn9hp8e	119	47	59	59	CD
cord-258536-qnn9hp8e	119	48	]	]	-RRB-
cord-258536-qnn9hp8e	119	49	.	.	.
cord-258536-qnn9hp8e	120	1	In	in	IN
cord-258536-qnn9hp8e	120	2	contrast	contrast	NN
cord-258536-qnn9hp8e	120	3	,	,	,
cord-258536-qnn9hp8e	120	4	Sun	Sun	NNP
cord-258536-qnn9hp8e	120	5	et	et	NNP
cord-258536-qnn9hp8e	120	6	al	al	NNP
cord-258536-qnn9hp8e	120	7	.	.	NNP
cord-258536-qnn9hp8e	120	8	showed	show	VBD
cord-258536-qnn9hp8e	120	9	,	,	,
cord-258536-qnn9hp8e	120	10	using	use	VBG
cord-258536-qnn9hp8e	120	11	confocal	confocal	JJ
cord-258536-qnn9hp8e	120	12	microscopy	microscopy	NNS
cord-258536-qnn9hp8e	120	13	,	,	,
cord-258536-qnn9hp8e	120	14	that	that	IN
cord-258536-qnn9hp8e	120	15	the	the	DT
cord-258536-qnn9hp8e	120	16	HP	HP	NNP
cord-258536-qnn9hp8e	120	17	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	120	18	infection	infection	NN
cord-258536-qnn9hp8e	120	19	inhibits	inhibit	VBZ
cord-258536-qnn9hp8e	120	20	the	the	DT
cord-258536-qnn9hp8e	120	21	fusion	fusion	NN
cord-258536-qnn9hp8e	120	22	between	between	IN
cord-258536-qnn9hp8e	120	23	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	120	24	and	and	CC
cord-258536-qnn9hp8e	120	25	lysosomes	lysosome	NNS
cord-258536-qnn9hp8e	120	26	[	[	-LRB-
cord-258536-qnn9hp8e	120	27	60	60	CD
cord-258536-qnn9hp8e	120	28	]	]	-RRB-
cord-258536-qnn9hp8e	120	29	.	.	.
cord-258536-qnn9hp8e	121	1	This	this	DT
cord-258536-qnn9hp8e	121	2	result	result	NN
cord-258536-qnn9hp8e	121	3	indicates	indicate	VBZ
cord-258536-qnn9hp8e	121	4	that	that	IN
cord-258536-qnn9hp8e	121	5	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	121	6	might	may	MD
cord-258536-qnn9hp8e	121	7	trigger	trigger	VB
cord-258536-qnn9hp8e	121	8	an	an	DT
cord-258536-qnn9hp8e	121	9	incomplete	incomplete	JJ
cord-258536-qnn9hp8e	121	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	121	11	and	and	CC
cord-258536-qnn9hp8e	121	12	implicates	implicate	VBZ
cord-258536-qnn9hp8e	121	13	that	that	IN
cord-258536-qnn9hp8e	121	14	this	this	DT
cord-258536-qnn9hp8e	121	15	could	could	MD
cord-258536-qnn9hp8e	121	16	be	be	VB
cord-258536-qnn9hp8e	121	17	beneficial	beneficial	JJ
cord-258536-qnn9hp8e	121	18	for	for	IN
cord-258536-qnn9hp8e	121	19	the	the	DT
cord-258536-qnn9hp8e	121	20	virus	virus	NN
cord-258536-qnn9hp8e	121	21	life	life	NN
cord-258536-qnn9hp8e	121	22	cycle	cycle	NN
cord-258536-qnn9hp8e	121	23	.	.	.
cord-258536-qnn9hp8e	122	1	To	to	TO
cord-258536-qnn9hp8e	122	2	gain	gain	VB
cord-258536-qnn9hp8e	122	3	insights	insight	NNS
cord-258536-qnn9hp8e	122	4	into	into	IN
cord-258536-qnn9hp8e	122	5	a	a	DT
cord-258536-qnn9hp8e	122	6	possible	possible	JJ
cord-258536-qnn9hp8e	122	7	molecular	molecular	JJ
cord-258536-qnn9hp8e	122	8	connection	connection	NN
cord-258536-qnn9hp8e	122	9	between	between	IN
cord-258536-qnn9hp8e	122	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	122	11	and	and	CC
cord-258536-qnn9hp8e	122	12	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	122	13	,	,	,
cord-258536-qnn9hp8e	122	14	they	-PRON-	PRP
cord-258536-qnn9hp8e	122	15	also	also	RB
cord-258536-qnn9hp8e	122	16	transfected	transfecte	VBD
cord-258536-qnn9hp8e	122	17	cells	cell	NNS
cord-258536-qnn9hp8e	122	18	with	with	IN
cord-258536-qnn9hp8e	122	19	either	either	CC
cord-258536-qnn9hp8e	122	20	nsp2	nsp2	NN
cord-258536-qnn9hp8e	122	21	or	or	CC
cord-258536-qnn9hp8e	122	22	nsp3	nsp3	NNS
cord-258536-qnn9hp8e	122	23	,	,	,
cord-258536-qnn9hp8e	122	24	which	which	WDT
cord-258536-qnn9hp8e	122	25	encode	encode	VBP
cord-258536-qnn9hp8e	122	26	two	two	CD
cord-258536-qnn9hp8e	122	27	transmembrane	transmembrane	NN
cord-258536-qnn9hp8e	122	28	components	component	NNS
cord-258536-qnn9hp8e	122	29	of	of	IN
cord-258536-qnn9hp8e	122	30	Arterivirus	Arterivirus	NNP
cord-258536-qnn9hp8e	122	31	RTCs	rtc	NNS
cord-258536-qnn9hp8e	122	32	that	that	WDT
cord-258536-qnn9hp8e	122	33	play	play	VBP
cord-258536-qnn9hp8e	122	34	a	a	DT
cord-258536-qnn9hp8e	122	35	central	central	JJ
cord-258536-qnn9hp8e	122	36	role	role	NN
cord-258536-qnn9hp8e	122	37	in	in	IN
cord-258536-qnn9hp8e	122	38	DMVs	dmv	NNS
cord-258536-qnn9hp8e	122	39	formation	formation	NN
cord-258536-qnn9hp8e	122	40	[	[	-LRB-
cord-258536-qnn9hp8e	122	41	63	63	CD
cord-258536-qnn9hp8e	122	42	]	]	-RRB-
cord-258536-qnn9hp8e	122	43	.	.	.
cord-258536-qnn9hp8e	123	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	123	2	,	,	,
cord-258536-qnn9hp8e	123	3	they	-PRON-	PRP
cord-258536-qnn9hp8e	123	4	found	find	VBD
cord-258536-qnn9hp8e	123	5	the	the	DT
cord-258536-qnn9hp8e	123	6	co	co	NN
cord-258536-qnn9hp8e	123	7	-	-	NN
cord-258536-qnn9hp8e	123	8	localization	localization	NN
cord-258536-qnn9hp8e	123	9	between	between	IN
cord-258536-qnn9hp8e	123	10	endogenous	endogenous	JJ
cord-258536-qnn9hp8e	123	11	LC3	lc3	NN
cord-258536-qnn9hp8e	123	12	and	and	CC
cord-258536-qnn9hp8e	123	13	ectopically	ectopically	RB
cord-258536-qnn9hp8e	123	14	expressed	express	VBD
cord-258536-qnn9hp8e	123	15	nsp2	nsp2	NNP
cord-258536-qnn9hp8e	123	16	,	,	,
cord-258536-qnn9hp8e	123	17	but	but	CC
cord-258536-qnn9hp8e	123	18	not	not	RB
cord-258536-qnn9hp8e	123	19	nsp3	nsp3	NNS
cord-258536-qnn9hp8e	123	20	,	,	,
cord-258536-qnn9hp8e	123	21	by	by	IN
cord-258536-qnn9hp8e	123	22	confocal	confocal	JJ
cord-258536-qnn9hp8e	123	23	microscopy	microscopy	NNS
cord-258536-qnn9hp8e	123	24	and	and	CC
cord-258536-qnn9hp8e	123	25	fractionation	fractionation	NN
cord-258536-qnn9hp8e	123	26	on	on	IN
cord-258536-qnn9hp8e	123	27	continuous	continuous	JJ
cord-258536-qnn9hp8e	123	28	density	density	NN
cord-258536-qnn9hp8e	123	29	gradients	gradient	NNS
cord-258536-qnn9hp8e	123	30	,	,	,
cord-258536-qnn9hp8e	123	31	suggesting	suggest	VBG
cord-258536-qnn9hp8e	123	32	that	that	IN
cord-258536-qnn9hp8e	123	33	the	the	DT
cord-258536-qnn9hp8e	123	34	accumulated	accumulate	VBN
cord-258536-qnn9hp8e	123	35	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	123	36	during	during	IN
cord-258536-qnn9hp8e	123	37	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	123	38	could	could	MD
cord-258536-qnn9hp8e	123	39	represent	represent	VB
cord-258536-qnn9hp8e	123	40	the	the	DT
cord-258536-qnn9hp8e	123	41	replicative	replicative	JJ
cord-258536-qnn9hp8e	123	42	platforms	platform	NNS
cord-258536-qnn9hp8e	123	43	[	[	-LRB-
cord-258536-qnn9hp8e	123	44	60	60	CD
cord-258536-qnn9hp8e	123	45	]	]	-RRB-
cord-258536-qnn9hp8e	123	46	.	.	.
cord-258536-qnn9hp8e	124	1	Thus	thus	RB
cord-258536-qnn9hp8e	124	2	,	,	,
cord-258536-qnn9hp8e	124	3	it	-PRON-	PRP
cord-258536-qnn9hp8e	124	4	still	still	RB
cord-258536-qnn9hp8e	124	5	remains	remain	VBZ
cord-258536-qnn9hp8e	124	6	to	to	TO
cord-258536-qnn9hp8e	124	7	be	be	VB
cord-258536-qnn9hp8e	124	8	firmly	firmly	RB
cord-258536-qnn9hp8e	124	9	demonstrated	demonstrate	VBN
cord-258536-qnn9hp8e	124	10	whether	whether	IN
cord-258536-qnn9hp8e	124	11	the	the	DT
cord-258536-qnn9hp8e	124	12	results	result	NNS
cord-258536-qnn9hp8e	124	13	obtained	obtain	VBN
cord-258536-qnn9hp8e	124	14	with	with	IN
cord-258536-qnn9hp8e	124	15	the	the	DT
cord-258536-qnn9hp8e	124	16	ectopic	ectopic	JJ
cord-258536-qnn9hp8e	124	17	expression	expression	NN
cord-258536-qnn9hp8e	124	18	of	of	IN
cord-258536-qnn9hp8e	124	19	nsp2	nsp2	NNP
cord-258536-qnn9hp8e	124	20	recapitulates	recapitulate	VBZ
cord-258536-qnn9hp8e	124	21	a	a	DT
cord-258536-qnn9hp8e	124	22	situation	situation	NN
cord-258536-qnn9hp8e	124	23	occurring	occur	VBG
cord-258536-qnn9hp8e	124	24	in	in	IN
cord-258536-qnn9hp8e	124	25	cells	cell	NNS
cord-258536-qnn9hp8e	124	26	exposed	expose	VBN
cord-258536-qnn9hp8e	124	27	to	to	IN
cord-258536-qnn9hp8e	124	28	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	124	29	.	.	.
cord-258536-qnn9hp8e	125	1	Recently	recently	RB
cord-258536-qnn9hp8e	125	2	,	,	,
cord-258536-qnn9hp8e	125	3	three	three	CD
cord-258536-qnn9hp8e	125	4	additional	additional	JJ
cord-258536-qnn9hp8e	125	5	research	research	NN
cord-258536-qnn9hp8e	125	6	articles	article	NNS
cord-258536-qnn9hp8e	125	7	provided	provide	VBD
cord-258536-qnn9hp8e	125	8	evidences	evidence	NNS
cord-258536-qnn9hp8e	125	9	that	that	IN
cord-258536-qnn9hp8e	125	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	125	11	but	but	CC
cord-258536-qnn9hp8e	125	12	also	also	RB
cord-258536-qnn9hp8e	125	13	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	125	14	are	be	VBP
cord-258536-qnn9hp8e	125	15	induced	induce	VBN
cord-258536-qnn9hp8e	125	16	by	by	IN
cord-258536-qnn9hp8e	125	17	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	125	18	in	in	IN
cord-258536-qnn9hp8e	125	19	host	host	NN
cord-258536-qnn9hp8e	125	20	cells	cell	NNS
cord-258536-qnn9hp8e	125	21	[	[	-LRB-
cord-258536-qnn9hp8e	125	22	61	61	CD
cord-258536-qnn9hp8e	125	23	,	,	,
cord-258536-qnn9hp8e	125	24	62	62	CD
cord-258536-qnn9hp8e	125	25	,	,	,
cord-258536-qnn9hp8e	125	26	64	64	CD
cord-258536-qnn9hp8e	125	27	]	]	-RRB-
cord-258536-qnn9hp8e	125	28	.	.	.
cord-258536-qnn9hp8e	126	1	Wang	Wang	NNP
cord-258536-qnn9hp8e	126	2	and	and	CC
cord-258536-qnn9hp8e	126	3	collaborators	collaborator	NNS
cord-258536-qnn9hp8e	126	4	investigated	investigate	VBD
cord-258536-qnn9hp8e	126	5	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	126	6	and	and	CC
cord-258536-qnn9hp8e	126	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	126	8	activation	activation	NN
cord-258536-qnn9hp8e	126	9	in	in	IN
cord-258536-qnn9hp8e	126	10	the	the	DT
cord-258536-qnn9hp8e	126	11	thymus	thymus	NN
cord-258536-qnn9hp8e	126	12	of	of	IN
cord-258536-qnn9hp8e	126	13	piglets	piglet	NNS
cord-258536-qnn9hp8e	126	14	infected	infect	VBN
cord-258536-qnn9hp8e	126	15	with	with	IN
cord-258536-qnn9hp8e	126	16	the	the	DT
cord-258536-qnn9hp8e	126	17	HP	HP	NNP
cord-258536-qnn9hp8e	126	18	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	126	19	strain	strain	VBP
cord-258536-qnn9hp8e	126	20	because	because	IN
cord-258536-qnn9hp8e	126	21	they	-PRON-	PRP
cord-258536-qnn9hp8e	126	22	previously	previously	RB
cord-258536-qnn9hp8e	126	23	showed	show	VBD
cord-258536-qnn9hp8e	126	24	that	that	IN
cord-258536-qnn9hp8e	126	25	this	this	DT
cord-258536-qnn9hp8e	126	26	virus	virus	NN
cord-258536-qnn9hp8e	126	27	leads	lead	VBZ
cord-258536-qnn9hp8e	126	28	to	to	IN
cord-258536-qnn9hp8e	126	29	thymic	thymic	JJ
cord-258536-qnn9hp8e	126	30	atrophy	atrophy	NN
cord-258536-qnn9hp8e	126	31	and	and	CC
cord-258536-qnn9hp8e	126	32	thymocyte	thymocyte	NN
cord-258536-qnn9hp8e	126	33	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	126	34	[	[	-LRB-
cord-258536-qnn9hp8e	126	35	61	61	CD
cord-258536-qnn9hp8e	126	36	]	]	-RRB-
cord-258536-qnn9hp8e	126	37	.	.	.
cord-258536-qnn9hp8e	127	1	Their	-PRON-	PRP$
cord-258536-qnn9hp8e	127	2	investigation	investigation	NN
cord-258536-qnn9hp8e	127	3	concluded	conclude	VBD
cord-258536-qnn9hp8e	127	4	that	that	IN
cord-258536-qnn9hp8e	127	5	the	the	DT
cord-258536-qnn9hp8e	127	6	HP	HP	NNP
cord-258536-qnn9hp8e	127	7	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	127	8	could	could	MD
cord-258536-qnn9hp8e	127	9	induce	induce	VB
cord-258536-qnn9hp8e	127	10	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	127	11	in	in	IN
cord-258536-qnn9hp8e	127	12	bystander	bystander	NN
cord-258536-qnn9hp8e	127	13	cells	cell	NNS
cord-258536-qnn9hp8e	127	14	and	and	CC
cord-258536-qnn9hp8e	127	15	autophagy	autophagy	NN
cord-258536-qnn9hp8e	127	16	in	in	IN
cord-258536-qnn9hp8e	127	17	both	both	CC
cord-258536-qnn9hp8e	127	18	infected	infect	VBN
cord-258536-qnn9hp8e	127	19	and	and	CC
cord-258536-qnn9hp8e	127	20	bystander	bystander	NN
cord-258536-qnn9hp8e	127	21	cells	cell	NNS
cord-258536-qnn9hp8e	127	22	in	in	IN
cord-258536-qnn9hp8e	127	23	the	the	DT
cord-258536-qnn9hp8e	127	24	thymus	thymus	NN
cord-258536-qnn9hp8e	127	25	of	of	IN
cord-258536-qnn9hp8e	127	26	infected	infected	JJ
cord-258536-qnn9hp8e	127	27	piglets	piglet	NNS
cord-258536-qnn9hp8e	127	28	[	[	-LRB-
cord-258536-qnn9hp8e	127	29	61	61	CD
cord-258536-qnn9hp8e	127	30	]	]	-RRB-
cord-258536-qnn9hp8e	127	31	.	.	.
cord-258536-qnn9hp8e	128	1	In	in	IN
cord-258536-qnn9hp8e	128	2	a	a	DT
cord-258536-qnn9hp8e	128	3	follow	follow	NN
cord-258536-qnn9hp8e	128	4	-	-	HYPH
cord-258536-qnn9hp8e	128	5	up	up	NN
cord-258536-qnn9hp8e	128	6	study	study	NN
cord-258536-qnn9hp8e	128	7	,	,	,
cord-258536-qnn9hp8e	128	8	another	another	DT
cord-258536-qnn9hp8e	128	9	laboratory	laboratory	NN
cord-258536-qnn9hp8e	128	10	found	find	VBD
cord-258536-qnn9hp8e	128	11	that	that	IN
cord-258536-qnn9hp8e	128	12	HP	HP	NNP
cord-258536-qnn9hp8e	128	13	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	128	14	replication	replication	NN
cord-258536-qnn9hp8e	128	15	was	be	VBD
cord-258536-qnn9hp8e	128	16	attenuated	attenuate	VBN
cord-258536-qnn9hp8e	128	17	in	in	IN
cord-258536-qnn9hp8e	128	18	autophagy	autophagy	NN
cord-258536-qnn9hp8e	128	19	deficient	deficient	JJ
cord-258536-qnn9hp8e	128	20	Marc-145	marc-145	CD
cord-258536-qnn9hp8e	128	21	cells	cell	NNS
cord-258536-qnn9hp8e	128	22	and	and	CC
cord-258536-qnn9hp8e	128	23	potentiated	potentiate	VBN
cord-258536-qnn9hp8e	128	24	by	by	IN
cord-258536-qnn9hp8e	128	25	inhibiting	inhibit	VBG
cord-258536-qnn9hp8e	128	26	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	128	27	using	use	VBG
cord-258536-qnn9hp8e	128	28	z	z	NNP
cord-258536-qnn9hp8e	128	29	-	-	HYPH
cord-258536-qnn9hp8e	128	30	VAD	VAD	NNP
cord-258536-qnn9hp8e	128	31	-	-	HYPH
cord-258536-qnn9hp8e	128	32	fmk	fmk	NNP
cord-258536-qnn9hp8e	128	33	,	,	,
cord-258536-qnn9hp8e	128	34	a	a	DT
cord-258536-qnn9hp8e	128	35	caspase	caspase	JJ
cord-258536-qnn9hp8e	128	36	pan	pan	NN
cord-258536-qnn9hp8e	128	37	-	-	JJ
cord-258536-qnn9hp8e	128	38	inhibitor	inhibitor	NN
cord-258536-qnn9hp8e	128	39	[	[	-LRB-
cord-258536-qnn9hp8e	128	40	62	62	CD
cord-258536-qnn9hp8e	128	41	]	]	-RRB-
cord-258536-qnn9hp8e	128	42	.	.	.
cord-258536-qnn9hp8e	129	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	129	2	,	,	,
cord-258536-qnn9hp8e	129	3	HP	HP	NNP
cord-258536-qnn9hp8e	129	4	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	129	5	replication	replication	NN
cord-258536-qnn9hp8e	129	6	could	could	MD
cord-258536-qnn9hp8e	129	7	be	be	VB
cord-258536-qnn9hp8e	129	8	restored	restore	VBN
cord-258536-qnn9hp8e	129	9	in	in	IN
cord-258536-qnn9hp8e	129	10	the	the	DT
cord-258536-qnn9hp8e	129	11	autophagy	autophagy	NN
cord-258536-qnn9hp8e	129	12	deficient	deficient	JJ
cord-258536-qnn9hp8e	129	13	cells	cell	NNS
cord-258536-qnn9hp8e	129	14	by	by	IN
cord-258536-qnn9hp8e	129	15	blocking	block	VBG
cord-258536-qnn9hp8e	129	16	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	129	17	,	,	,
cord-258536-qnn9hp8e	129	18	suggesting	suggest	VBG
cord-258536-qnn9hp8e	129	19	a	a	DT
cord-258536-qnn9hp8e	129	20	functional	functional	JJ
cord-258536-qnn9hp8e	129	21	interplay	interplay	NN
cord-258536-qnn9hp8e	129	22	between	between	IN
cord-258536-qnn9hp8e	129	23	autophagy	autophagy	NN
cord-258536-qnn9hp8e	129	24	and	and	CC
cord-258536-qnn9hp8e	129	25	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	129	26	during	during	IN
cord-258536-qnn9hp8e	129	27	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	129	28	replication	replication	NN
cord-258536-qnn9hp8e	129	29	.	.	.
cord-258536-qnn9hp8e	130	1	Subsequently	subsequently	RB
cord-258536-qnn9hp8e	130	2	,	,	,
cord-258536-qnn9hp8e	130	3	Zhou	Zhou	NNP
cord-258536-qnn9hp8e	130	4	et	et	NNP
cord-258536-qnn9hp8e	130	5	al	al	NNP
cord-258536-qnn9hp8e	130	6	.	.	.
cord-258536-qnn9hp8e	131	1	confirmed	confirm	VBD
cord-258536-qnn9hp8e	131	2	the	the	DT
cord-258536-qnn9hp8e	131	3	activation	activation	NN
cord-258536-qnn9hp8e	131	4	of	of	IN
cord-258536-qnn9hp8e	131	5	autophagy	autophagy	NN
cord-258536-qnn9hp8e	131	6	and	and	CC
cord-258536-qnn9hp8e	131	7	a	a	DT
cord-258536-qnn9hp8e	131	8	subsequent	subsequent	JJ
cord-258536-qnn9hp8e	131	9	induction	induction	NN
cord-258536-qnn9hp8e	131	10	of	of	IN
cord-258536-qnn9hp8e	131	11	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	131	12	over	over	IN
cord-258536-qnn9hp8e	131	13	the	the	DT
cord-258536-qnn9hp8e	131	14	course	course	NN
cord-258536-qnn9hp8e	131	15	of	of	IN
cord-258536-qnn9hp8e	131	16	a	a	DT
cord-258536-qnn9hp8e	131	17	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	131	18	infection	infection	NN
cord-258536-qnn9hp8e	131	19	in	in	IN
cord-258536-qnn9hp8e	131	20	Marc-145	marc-145	CD
cord-258536-qnn9hp8e	131	21	cells	cell	NNS
cord-258536-qnn9hp8e	131	22	[	[	-LRB-
cord-258536-qnn9hp8e	131	23	64	64	CD
cord-258536-qnn9hp8e	131	24	]	]	-RRB-
cord-258536-qnn9hp8e	131	25	.	.	.
cord-258536-qnn9hp8e	132	1	In	in	IN
cord-258536-qnn9hp8e	132	2	their	-PRON-	PRP$
cord-258536-qnn9hp8e	132	3	study	study	NN
cord-258536-qnn9hp8e	132	4	,	,	,
cord-258536-qnn9hp8e	132	5	inhibition	inhibition	NN
cord-258536-qnn9hp8e	132	6	of	of	IN
cord-258536-qnn9hp8e	132	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	132	8	by	by	IN
cord-258536-qnn9hp8e	132	9	3-MA	3-ma	CD
cord-258536-qnn9hp8e	132	10	caused	cause	VBD
cord-258536-qnn9hp8e	132	11	a	a	DT
cord-258536-qnn9hp8e	132	12	significant	significant	JJ
cord-258536-qnn9hp8e	132	13	increase	increase	NN
cord-258536-qnn9hp8e	132	14	in	in	IN
cord-258536-qnn9hp8e	132	15	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	132	16	-	-	HYPH
cord-258536-qnn9hp8e	132	17	induced	induce	VBN
cord-258536-qnn9hp8e	132	18	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	132	19	,	,	,
cord-258536-qnn9hp8e	132	20	also	also	RB
cord-258536-qnn9hp8e	132	21	unveiling	unveil	VBG
cord-258536-qnn9hp8e	132	22	a	a	DT
cord-258536-qnn9hp8e	132	23	potential	potential	JJ
cord-258536-qnn9hp8e	132	24	connection	connection	NN
cord-258536-qnn9hp8e	132	25	between	between	IN
cord-258536-qnn9hp8e	132	26	both	both	DT
cord-258536-qnn9hp8e	132	27	mechanisms	mechanism	NNS
cord-258536-qnn9hp8e	132	28	.	.	.
cord-258536-qnn9hp8e	133	1	In	in	IN
cord-258536-qnn9hp8e	133	2	line	line	NN
cord-258536-qnn9hp8e	133	3	with	with	IN
cord-258536-qnn9hp8e	133	4	this	this	DT
cord-258536-qnn9hp8e	133	5	conclusion	conclusion	NN
cord-258536-qnn9hp8e	133	6	,	,	,
cord-258536-qnn9hp8e	133	7	they	-PRON-	PRP
cord-258536-qnn9hp8e	133	8	also	also	RB
cord-258536-qnn9hp8e	133	9	observed	observe	VBD
cord-258536-qnn9hp8e	133	10	an	an	DT
cord-258536-qnn9hp8e	133	11	increase	increase	NN
cord-258536-qnn9hp8e	133	12	in	in	IN
cord-258536-qnn9hp8e	133	13	the	the	DT
cord-258536-qnn9hp8e	133	14	expression	expression	NN
cord-258536-qnn9hp8e	133	15	of	of	IN
cord-258536-qnn9hp8e	133	16	Bcl-2-associated	Bcl-2-associated	NNP
cord-258536-qnn9hp8e	133	17	death	death	NN
cord-258536-qnn9hp8e	133	18	promoter	promoter	NN
cord-258536-qnn9hp8e	133	19	(	(	-LRB-
cord-258536-qnn9hp8e	133	20	BAD	BAD	NNP
cord-258536-qnn9hp8e	133	21	)	)	-RRB-
cord-258536-qnn9hp8e	133	22	,	,	,
cord-258536-qnn9hp8e	133	23	a	a	DT
cord-258536-qnn9hp8e	133	24	pro	pro	JJ
cord-258536-qnn9hp8e	133	25	-	-	JJ
cord-258536-qnn9hp8e	133	26	apoptosis	apoptosis	JJ
cord-258536-qnn9hp8e	133	27	protein	protein	NN
cord-258536-qnn9hp8e	133	28	,	,	,
cord-258536-qnn9hp8e	133	29	and	and	CC
cord-258536-qnn9hp8e	133	30	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	133	31	,	,	,
cord-258536-qnn9hp8e	133	32	an	an	DT
cord-258536-qnn9hp8e	133	33	autophagy	autophagy	NN
cord-258536-qnn9hp8e	133	34	regulator	regulator	NN
cord-258536-qnn9hp8e	133	35	.	.	.
cord-258536-qnn9hp8e	134	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	134	2	,	,	,
cord-258536-qnn9hp8e	134	3	co	co	VBN
cord-258536-qnn9hp8e	134	4	-	-	JJ
cord-258536-qnn9hp8e	134	5	immunoprecipitation	immunoprecipitation	JJ
cord-258536-qnn9hp8e	134	6	and	and	CC
cord-258536-qnn9hp8e	134	7	confocal	confocal	JJ
cord-258536-qnn9hp8e	134	8	microscopy	microscopy	NN
cord-258536-qnn9hp8e	134	9	experiments	experiment	NNS
cord-258536-qnn9hp8e	134	10	revealed	reveal	VBD
cord-258536-qnn9hp8e	134	11	the	the	DT
cord-258536-qnn9hp8e	134	12	formation	formation	NN
cord-258536-qnn9hp8e	134	13	of	of	IN
cord-258536-qnn9hp8e	134	14	a	a	DT
cord-258536-qnn9hp8e	134	15	BAD	BAD	NNP
cord-258536-qnn9hp8e	134	16	-	-	HYPH
cord-258536-qnn9hp8e	134	17	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	134	18	complex	complex	JJ
cord-258536-qnn9hp8e	134	19	in	in	IN
cord-258536-qnn9hp8e	134	20	infected	infected	JJ
cord-258536-qnn9hp8e	134	21	cells	cell	NNS
cord-258536-qnn9hp8e	134	22	[	[	-LRB-
cord-258536-qnn9hp8e	134	23	64	64	CD
cord-258536-qnn9hp8e	134	24	]	]	-RRB-
cord-258536-qnn9hp8e	134	25	.	.	.
cord-258536-qnn9hp8e	135	1	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	135	2	knockdown	knockdown	VBP
cord-258536-qnn9hp8e	135	3	significantly	significantly	RB
cord-258536-qnn9hp8e	135	4	decreased	decrease	VBD
cord-258536-qnn9hp8e	135	5	viral	viral	JJ
cord-258536-qnn9hp8e	135	6	replication	replication	NN
cord-258536-qnn9hp8e	135	7	and	and	CC
cord-258536-qnn9hp8e	135	8	PRRSV	prrsv	NN
cord-258536-qnn9hp8e	135	9	-	-	HYPH
cord-258536-qnn9hp8e	135	10	induced	induce	VBN
cord-258536-qnn9hp8e	135	11	autophagy	autophagy	NN
cord-258536-qnn9hp8e	135	12	as	as	IN
cord-258536-qnn9hp8e	135	13	expected	expect	VBN
cord-258536-qnn9hp8e	136	1	,	,	,
cord-258536-qnn9hp8e	136	2	while	while	IN
cord-258536-qnn9hp8e	136	3	knocking	knock	VBG
cord-258536-qnn9hp8e	136	4	down	down	IN
cord-258536-qnn9hp8e	136	5	of	of	IN
cord-258536-qnn9hp8e	136	6	BAD	BAD	NNP
cord-258536-qnn9hp8e	136	7	resulted	result	VBD
cord-258536-qnn9hp8e	136	8	in	in	IN
cord-258536-qnn9hp8e	136	9	an	an	DT
cord-258536-qnn9hp8e	136	10	induction	induction	NN
cord-258536-qnn9hp8e	136	11	of	of	IN
cord-258536-qnn9hp8e	136	12	autophagy	autophagy	NN
cord-258536-qnn9hp8e	136	13	and	and	CC
cord-258536-qnn9hp8e	136	14	enhanced	enhance	VBN
cord-258536-qnn9hp8e	136	15	viral	viral	JJ
cord-258536-qnn9hp8e	136	16	replication	replication	NN
cord-258536-qnn9hp8e	136	17	[	[	-LRB-
cord-258536-qnn9hp8e	136	18	64	64	CD
cord-258536-qnn9hp8e	136	19	]	]	-RRB-
cord-258536-qnn9hp8e	136	20	.	.	.
cord-258536-qnn9hp8e	137	1	The	the	DT
cord-258536-qnn9hp8e	137	2	authors	author	NNS
cord-258536-qnn9hp8e	137	3	concluded	conclude	VBD
cord-258536-qnn9hp8e	137	4	that	that	IN
cord-258536-qnn9hp8e	137	5	the	the	DT
cord-258536-qnn9hp8e	137	6	enhancement	enhancement	NN
cord-258536-qnn9hp8e	137	7	of	of	IN
cord-258536-qnn9hp8e	137	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	137	9	could	could	MD
cord-258536-qnn9hp8e	137	10	promote	promote	VB
cord-258536-qnn9hp8e	137	11	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	137	12	replication	replication	NN
cord-258536-qnn9hp8e	137	13	by	by	IN
cord-258536-qnn9hp8e	137	14	postponing	postpone	VBG
cord-258536-qnn9hp8e	137	15	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	137	16	through	through	IN
cord-258536-qnn9hp8e	137	17	the	the	DT
cord-258536-qnn9hp8e	137	18	formation	formation	NN
cord-258536-qnn9hp8e	137	19	of	of	IN
cord-258536-qnn9hp8e	137	20	the	the	DT
cord-258536-qnn9hp8e	137	21	BAD	BAD	NNP
cord-258536-qnn9hp8e	137	22	-	-	HYPH
cord-258536-qnn9hp8e	137	23	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	137	24	complex	complex	JJ
cord-258536-qnn9hp8e	137	25	[	[	-LRB-
cord-258536-qnn9hp8e	137	26	64	64	CD
cord-258536-qnn9hp8e	137	27	]	]	-RRB-
cord-258536-qnn9hp8e	137	28	.	.	.
cord-258536-qnn9hp8e	138	1	In	in	IN
cord-258536-qnn9hp8e	138	2	a	a	DT
cord-258536-qnn9hp8e	138	3	study	study	NN
cord-258536-qnn9hp8e	138	4	exploring	explore	VBG
cord-258536-qnn9hp8e	138	5	a	a	DT
cord-258536-qnn9hp8e	138	6	potential	potential	JJ
cord-258536-qnn9hp8e	138	7	connection	connection	NN
cord-258536-qnn9hp8e	138	8	between	between	IN
cord-258536-qnn9hp8e	138	9	EAV	EAV	NNP
cord-258536-qnn9hp8e	138	10	and	and	CC
cord-258536-qnn9hp8e	138	11	autophagy	autophagy	NN
cord-258536-qnn9hp8e	138	12	,	,	,
cord-258536-qnn9hp8e	138	13	Monastyrska	Monastyrska	NNP
cord-258536-qnn9hp8e	138	14	et	et	NNP
cord-258536-qnn9hp8e	138	15	al	al	NNP
cord-258536-qnn9hp8e	138	16	.	.	.
cord-258536-qnn9hp8e	139	1	found	find	VBD
cord-258536-qnn9hp8e	139	2	that	that	IN
cord-258536-qnn9hp8e	139	3	the	the	DT
cord-258536-qnn9hp8e	139	4	DMVs	dmv	NNS
cord-258536-qnn9hp8e	139	5	induced	induce	VBN
cord-258536-qnn9hp8e	139	6	by	by	IN
cord-258536-qnn9hp8e	139	7	this	this	DT
cord-258536-qnn9hp8e	139	8	virus	virus	NN
cord-258536-qnn9hp8e	139	9	are	be	VBP
cord-258536-qnn9hp8e	139	10	decorated	decorate	VBN
cord-258536-qnn9hp8e	139	11	with	with	IN
cord-258536-qnn9hp8e	139	12	LC3	LC3	NNP
cord-258536-qnn9hp8e	139	13	but	but	CC
cord-258536-qnn9hp8e	139	14	the	the	DT
cord-258536-qnn9hp8e	139	15	EAV	EAV	NNP
cord-258536-qnn9hp8e	139	16	life	life	NN
cord-258536-qnn9hp8e	139	17	cycle	cycle	NN
cord-258536-qnn9hp8e	139	18	proceeded	proceed	VBD
cord-258536-qnn9hp8e	139	19	unaffected	unaffected	JJ
cord-258536-qnn9hp8e	139	20	in	in	IN
cord-258536-qnn9hp8e	139	21	cells	cell	NNS
cord-258536-qnn9hp8e	139	22	lacking	lack	VBG
cord-258536-qnn9hp8e	139	23	ATG7	ATG7	NNP
cord-258536-qnn9hp8e	139	24	[	[	-LRB-
cord-258536-qnn9hp8e	139	25	68	68	CD
cord-258536-qnn9hp8e	139	26	]	]	-RRB-
cord-258536-qnn9hp8e	139	27	.	.	.
cord-258536-qnn9hp8e	140	1	Although	although	IN
cord-258536-qnn9hp8e	140	2	autophagy	autophagy	NN
cord-258536-qnn9hp8e	140	3	was	be	VBD
cord-258536-qnn9hp8e	140	4	not	not	RB
cord-258536-qnn9hp8e	140	5	required	require	VBN
cord-258536-qnn9hp8e	140	6	,	,	,
cord-258536-qnn9hp8e	140	7	depletion	depletion	NN
cord-258536-qnn9hp8e	140	8	of	of	IN
cord-258536-qnn9hp8e	140	9	LC3	lc3	NN
cord-258536-qnn9hp8e	140	10	markedly	markedly	RB
cord-258536-qnn9hp8e	140	11	reduced	reduce	VBD
cord-258536-qnn9hp8e	140	12	EAV	EAV	NNP
cord-258536-qnn9hp8e	140	13	replication	replication	NN
cord-258536-qnn9hp8e	140	14	and	and	CC
cord-258536-qnn9hp8e	140	15	it	-PRON-	PRP
cord-258536-qnn9hp8e	140	16	could	could	MD
cord-258536-qnn9hp8e	140	17	be	be	VB
cord-258536-qnn9hp8e	140	18	fully	fully	RB
cord-258536-qnn9hp8e	140	19	restored	restore	VBN
cord-258536-qnn9hp8e	140	20	by	by	IN
cord-258536-qnn9hp8e	140	21	expression	expression	NN
cord-258536-qnn9hp8e	140	22	of	of	IN
cord-258536-qnn9hp8e	140	23	a	a	DT
cord-258536-qnn9hp8e	140	24	non	non	JJ
cord-258536-qnn9hp8e	140	25	-	-	JJ
cord-258536-qnn9hp8e	140	26	lipidable	lipidable	JJ
cord-258536-qnn9hp8e	140	27	form	form	NN
cord-258536-qnn9hp8e	140	28	of	of	IN
cord-258536-qnn9hp8e	140	29	LC3	LC3	NNP
cord-258536-qnn9hp8e	140	30	[	[	-LRB-
cord-258536-qnn9hp8e	140	31	68	68	CD
cord-258536-qnn9hp8e	140	32	]	]	-RRB-
cord-258536-qnn9hp8e	140	33	.	.	.
cord-258536-qnn9hp8e	141	1	Similar	similar	JJ
cord-258536-qnn9hp8e	141	2	to	to	IN
cord-258536-qnn9hp8e	141	3	MHV	MHV	NNP
cord-258536-qnn9hp8e	141	4	,	,	,
cord-258536-qnn9hp8e	141	5	EAV	EAV	NNP
cord-258536-qnn9hp8e	141	6	-	-	HYPH
cord-258536-qnn9hp8e	141	7	induced	induce	VBN
cord-258536-qnn9hp8e	141	8	DMVs	dmv	NNS
cord-258536-qnn9hp8e	141	9	were	be	VBD
cord-258536-qnn9hp8e	141	10	also	also	RB
cord-258536-qnn9hp8e	141	11	positive	positive	JJ
cord-258536-qnn9hp8e	141	12	for	for	IN
cord-258536-qnn9hp8e	141	13	EDEM1	edem1	NN
cord-258536-qnn9hp8e	142	1	(	(	-LRB-
cord-258536-qnn9hp8e	142	2	ER	ER	NNP
cord-258536-qnn9hp8e	142	3	Degradation	Degradation	NNP
cord-258536-qnn9hp8e	142	4	Enhancing	Enhancing	NNP
cord-258536-qnn9hp8e	142	5	Alpha	Alpha	NNP
cord-258536-qnn9hp8e	142	6	-	-	HYPH
cord-258536-qnn9hp8e	142	7	Mannosidase	mannosidase	NN
cord-258536-qnn9hp8e	143	1	Like	like	IN
cord-258536-qnn9hp8e	143	2	Protein	protein	NN
cord-258536-qnn9hp8e	143	3	1	1	CD
cord-258536-qnn9hp8e	143	4	)	)	-RRB-
cord-258536-qnn9hp8e	144	1	leading	lead	VBG
cord-258536-qnn9hp8e	144	2	to	to	IN
cord-258536-qnn9hp8e	144	3	the	the	DT
cord-258536-qnn9hp8e	144	4	conclusion	conclusion	NN
cord-258536-qnn9hp8e	144	5	that	that	IN
cord-258536-qnn9hp8e	144	6	EAV	EAV	NNP
cord-258536-qnn9hp8e	144	7	might	may	MD
cord-258536-qnn9hp8e	144	8	also	also	RB
cord-258536-qnn9hp8e	144	9	hijack	hijack	VB
cord-258536-qnn9hp8e	144	10	the	the	DT
cord-258536-qnn9hp8e	144	11	ER	er	NN
cord-258536-qnn9hp8e	144	12	-	-	HYPH
cord-258536-qnn9hp8e	144	13	derived	derive	VBN
cord-258536-qnn9hp8e	144	14	membranes	membrane	NNS
cord-258536-qnn9hp8e	144	15	of	of	IN
cord-258536-qnn9hp8e	144	16	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	144	17	to	to	TO
cord-258536-qnn9hp8e	144	18	ensure	ensure	VB
cord-258536-qnn9hp8e	144	19	its	-PRON-	PRP$
cord-258536-qnn9hp8e	144	20	replication	replication	NN
cord-258536-qnn9hp8e	144	21	[	[	-LRB-
cord-258536-qnn9hp8e	144	22	67	67	CD
cord-258536-qnn9hp8e	144	23	,	,	,
cord-258536-qnn9hp8e	144	24	68	68	CD
cord-258536-qnn9hp8e	144	25	]	]	-RRB-
cord-258536-qnn9hp8e	144	26	.	.	.
cord-258536-qnn9hp8e	145	1	It	-PRON-	PRP
cord-258536-qnn9hp8e	145	2	still	still	RB
cord-258536-qnn9hp8e	145	3	needs	need	VBZ
cord-258536-qnn9hp8e	145	4	to	to	TO
cord-258536-qnn9hp8e	145	5	be	be	VB
cord-258536-qnn9hp8e	145	6	investigated	investigate	VBN
cord-258536-qnn9hp8e	145	7	,	,	,
cord-258536-qnn9hp8e	145	8	however	however	RB
cord-258536-qnn9hp8e	145	9	,	,	,
cord-258536-qnn9hp8e	145	10	whether	whether	IN
cord-258536-qnn9hp8e	145	11	other	other	JJ
cord-258536-qnn9hp8e	145	12	ATG	ATG	NNP
cord-258536-qnn9hp8e	145	13	proteins	protein	NNS
cord-258536-qnn9hp8e	145	14	are	be	VBP
cord-258536-qnn9hp8e	145	15	dispensable	dispensable	JJ
cord-258536-qnn9hp8e	145	16	for	for	IN
cord-258536-qnn9hp8e	145	17	EAV	EAV	NNP
cord-258536-qnn9hp8e	145	18	life	life	NN
cord-258536-qnn9hp8e	145	19	cycle	cycle	NN
cord-258536-qnn9hp8e	145	20	.	.	.
cord-258536-qnn9hp8e	146	1	Furthermore	furthermore	RB
cord-258536-qnn9hp8e	146	2	,	,	,
cord-258536-qnn9hp8e	146	3	it	-PRON-	PRP
cord-258536-qnn9hp8e	146	4	is	be	VBZ
cord-258536-qnn9hp8e	146	5	unclear	unclear	JJ
cord-258536-qnn9hp8e	146	6	whether	whether	IN
cord-258536-qnn9hp8e	146	7	both	both	DT
cord-258536-qnn9hp8e	146	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	146	9	and	and	CC
cord-258536-qnn9hp8e	146	10	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	146	11	are	be	VBP
cord-258536-qnn9hp8e	146	12	induced	induce	VBN
cord-258536-qnn9hp8e	146	13	over	over	IN
cord-258536-qnn9hp8e	146	14	the	the	DT
cord-258536-qnn9hp8e	146	15	course	course	NN
cord-258536-qnn9hp8e	146	16	of	of	IN
cord-258536-qnn9hp8e	146	17	an	an	DT
cord-258536-qnn9hp8e	146	18	EAV	EAV	NNP
cord-258536-qnn9hp8e	146	19	infection	infection	NN
cord-258536-qnn9hp8e	146	20	as	as	IN
cord-258536-qnn9hp8e	146	21	observed	observe	VBN
cord-258536-qnn9hp8e	146	22	for	for	IN
cord-258536-qnn9hp8e	146	23	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	146	24	.	.	.
cord-258536-qnn9hp8e	147	1	The	the	DT
cord-258536-qnn9hp8e	147	2	most	most	RBS
cord-258536-qnn9hp8e	147	3	studied	study	VBN
cord-258536-qnn9hp8e	147	4	alphacoronaviruses	alphacoronaviruse	NNS
cord-258536-qnn9hp8e	147	5	(	(	-LRB-
cord-258536-qnn9hp8e	147	6	alpha	alpha	NN
cord-258536-qnn9hp8e	147	7	-	-	HYPH
cord-258536-qnn9hp8e	147	8	CoVs	CoVs	NNP
cord-258536-qnn9hp8e	147	9	)	)	-RRB-
cord-258536-qnn9hp8e	147	10	are	be	VBP
cord-258536-qnn9hp8e	147	11	the	the	DT
cord-258536-qnn9hp8e	147	12	Transmissible	transmissible	JJ
cord-258536-qnn9hp8e	147	13	Gastroenteritis	Gastroenteritis	NNP
cord-258536-qnn9hp8e	147	14	Virus	virus	NN
cord-258536-qnn9hp8e	147	15	(	(	-LRB-
cord-258536-qnn9hp8e	147	16	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	147	17	)	)	-RRB-
cord-258536-qnn9hp8e	147	18	and	and	CC
cord-258536-qnn9hp8e	147	19	Porcine	Porcine	NNP
cord-258536-qnn9hp8e	147	20	Epidemic	Epidemic	NNP
cord-258536-qnn9hp8e	147	21	Diarrhea	diarrhea	NN
cord-258536-qnn9hp8e	147	22	Virus	virus	NN
cord-258536-qnn9hp8e	147	23	(	(	-LRB-
cord-258536-qnn9hp8e	147	24	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	147	25	)	)	-RRB-
cord-258536-qnn9hp8e	147	26	,	,	,
cord-258536-qnn9hp8e	147	27	which	which	WDT
cord-258536-qnn9hp8e	147	28	both	both	DT
cord-258536-qnn9hp8e	147	29	infect	infect	VBP
cord-258536-qnn9hp8e	147	30	suckling	suckle	VBG
cord-258536-qnn9hp8e	147	31	piglets	piglet	NNS
cord-258536-qnn9hp8e	147	32	and	and	CC
cord-258536-qnn9hp8e	147	33	lead	lead	VB
cord-258536-qnn9hp8e	147	34	to	to	IN
cord-258536-qnn9hp8e	147	35	a	a	DT
cord-258536-qnn9hp8e	147	36	high	high	JJ
cord-258536-qnn9hp8e	147	37	mortality	mortality	NN
cord-258536-qnn9hp8e	147	38	rate	rate	NN
cord-258536-qnn9hp8e	147	39	[	[	-LRB-
cord-258536-qnn9hp8e	147	40	72	72	CD
cord-258536-qnn9hp8e	147	41	,	,	,
cord-258536-qnn9hp8e	147	42	73	73	CD
cord-258536-qnn9hp8e	147	43	]	]	-RRB-
cord-258536-qnn9hp8e	147	44	.	.	.
cord-258536-qnn9hp8e	148	1	Recurrent	recurrent	JJ
cord-258536-qnn9hp8e	148	2	outbreaks	outbreak	NNS
cord-258536-qnn9hp8e	148	3	of	of	IN
cord-258536-qnn9hp8e	148	4	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	148	5	have	have	VBP
cord-258536-qnn9hp8e	148	6	occurred	occur	VBN
cord-258536-qnn9hp8e	148	7	across	across	IN
cord-258536-qnn9hp8e	148	8	Asia	Asia	NNP
cord-258536-qnn9hp8e	148	9	and	and	CC
cord-258536-qnn9hp8e	148	10	the	the	DT
cord-258536-qnn9hp8e	148	11	USA	USA	NNP
cord-258536-qnn9hp8e	148	12	,	,	,
cord-258536-qnn9hp8e	148	13	causing	cause	VBG
cord-258536-qnn9hp8e	148	14	significant	significant	JJ
cord-258536-qnn9hp8e	148	15	economic	economic	JJ
cord-258536-qnn9hp8e	148	16	losses	loss	NNS
cord-258536-qnn9hp8e	148	17	[	[	-LRB-
cord-258536-qnn9hp8e	148	18	73	73	CD
cord-258536-qnn9hp8e	148	19	]	]	-RRB-
cord-258536-qnn9hp8e	148	20	.	.	.
cord-258536-qnn9hp8e	149	1	Alpha	Alpha	NNP
cord-258536-qnn9hp8e	149	2	-	-	HYPH
cord-258536-qnn9hp8e	149	3	CoV	CoV	NNP
cord-258536-qnn9hp8e	149	4	also	also	RB
cord-258536-qnn9hp8e	149	5	includes	include	VBZ
cord-258536-qnn9hp8e	149	6	human	human	JJ
cord-258536-qnn9hp8e	149	7	pathogens	pathogen	NNS
cord-258536-qnn9hp8e	149	8	such	such	JJ
cord-258536-qnn9hp8e	149	9	as	as	IN
cord-258536-qnn9hp8e	149	10	HCoV-229E	HCoV-229E	NNP
cord-258536-qnn9hp8e	149	11	and	and	CC
cord-258536-qnn9hp8e	149	12	HCoV	HCoV	NNP
cord-258536-qnn9hp8e	149	13	-	-	HYPH
cord-258536-qnn9hp8e	149	14	NL63	NL63	NNP
cord-258536-qnn9hp8e	149	15	,	,	,
cord-258536-qnn9hp8e	149	16	which	which	WDT
cord-258536-qnn9hp8e	149	17	are	be	VBP
cord-258536-qnn9hp8e	149	18	associated	associate	VBN
cord-258536-qnn9hp8e	149	19	with	with	IN
cord-258536-qnn9hp8e	149	20	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	149	21	tract	tract	NN
cord-258536-qnn9hp8e	149	22	infections	infection	NNS
cord-258536-qnn9hp8e	149	23	such	such	JJ
cord-258536-qnn9hp8e	149	24	as	as	IN
cord-258536-qnn9hp8e	149	25	the	the	DT
cord-258536-qnn9hp8e	149	26	common	common	JJ
cord-258536-qnn9hp8e	149	27	cold	cold	NN
cord-258536-qnn9hp8e	149	28	to	to	IN
cord-258536-qnn9hp8e	149	29	bronchiolitis	bronchiolitis	VB
cord-258536-qnn9hp8e	149	30	[	[	-LRB-
cord-258536-qnn9hp8e	149	31	74	74	CD
cord-258536-qnn9hp8e	149	32	,	,	,
cord-258536-qnn9hp8e	149	33	75	75	CD
cord-258536-qnn9hp8e	149	34	]	]	-RRB-
cord-258536-qnn9hp8e	149	35	.	.	.
cord-258536-qnn9hp8e	150	1	Despite	despite	IN
cord-258536-qnn9hp8e	150	2	their	-PRON-	PRP$
cord-258536-qnn9hp8e	150	3	medical	medical	JJ
cord-258536-qnn9hp8e	150	4	and	and	CC
cord-258536-qnn9hp8e	150	5	veterinary	veterinary	JJ
cord-258536-qnn9hp8e	150	6	relevance	relevance	NN
cord-258536-qnn9hp8e	150	7	,	,	,
cord-258536-qnn9hp8e	150	8	however	however	RB
cord-258536-qnn9hp8e	150	9	,	,	,
cord-258536-qnn9hp8e	150	10	the	the	DT
cord-258536-qnn9hp8e	150	11	exact	exact	JJ
cord-258536-qnn9hp8e	150	12	mechanisms	mechanism	NNS
cord-258536-qnn9hp8e	150	13	of	of	IN
cord-258536-qnn9hp8e	150	14	alpha	alpha	NN
cord-258536-qnn9hp8e	150	15	-	-	HYPH
cord-258536-qnn9hp8e	150	16	CoV	cov	NN
cord-258536-qnn9hp8e	150	17	replication	replication	NN
cord-258536-qnn9hp8e	150	18	and	and	CC
cord-258536-qnn9hp8e	150	19	pathogenesis	pathogenesis	NN
cord-258536-qnn9hp8e	150	20	are	be	VBP
cord-258536-qnn9hp8e	150	21	not	not	RB
cord-258536-qnn9hp8e	150	22	well	well	RB
cord-258536-qnn9hp8e	150	23	characterized	characterize	VBN
cord-258536-qnn9hp8e	150	24	yet	yet	RB
cord-258536-qnn9hp8e	150	25	.	.	.
cord-258536-qnn9hp8e	151	1	Sun	Sun	NNP
cord-258536-qnn9hp8e	151	2	et	et	NNP
cord-258536-qnn9hp8e	151	3	al	al	NNP
cord-258536-qnn9hp8e	151	4	.	.	.
cord-258536-qnn9hp8e	152	1	recently	recently	RB
cord-258536-qnn9hp8e	152	2	performed	perform	VBD
cord-258536-qnn9hp8e	152	3	a	a	DT
cord-258536-qnn9hp8e	152	4	high	high	JJ
cord-258536-qnn9hp8e	152	5	throughput	throughput	NN
cord-258536-qnn9hp8e	152	6	mass	mass	NN
cord-258536-qnn9hp8e	152	7	spectrometry	spectrometry	NN
cord-258536-qnn9hp8e	152	8	analysis	analysis	NN
cord-258536-qnn9hp8e	152	9	in	in	IN
cord-258536-qnn9hp8e	152	10	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	152	11	-	-	HYPH
cord-258536-qnn9hp8e	152	12	infected	infect	VBN
cord-258536-qnn9hp8e	152	13	Vero	Vero	NNP
cord-258536-qnn9hp8e	152	14	cells	cell	NNS
cord-258536-qnn9hp8e	152	15	[	[	-LRB-
cord-258536-qnn9hp8e	152	16	76	76	CD
cord-258536-qnn9hp8e	152	17	]	]	-RRB-
cord-258536-qnn9hp8e	152	18	.	.	.
cord-258536-qnn9hp8e	153	1	Their	-PRON-	PRP$
cord-258536-qnn9hp8e	153	2	goal	goal	NN
cord-258536-qnn9hp8e	153	3	was	be	VBD
cord-258536-qnn9hp8e	153	4	to	to	TO
cord-258536-qnn9hp8e	153	5	identify	identify	VB
cord-258536-qnn9hp8e	153	6	which	which	WDT
cord-258536-qnn9hp8e	153	7	cellular	cellular	JJ
cord-258536-qnn9hp8e	153	8	proteins	protein	NNS
cord-258536-qnn9hp8e	153	9	are	be	VBP
cord-258536-qnn9hp8e	153	10	differentially	differentially	RB
cord-258536-qnn9hp8e	153	11	expressed	express	VBN
cord-258536-qnn9hp8e	153	12	during	during	IN
cord-258536-qnn9hp8e	153	13	viral	viral	JJ
cord-258536-qnn9hp8e	153	14	infection	infection	NN
cord-258536-qnn9hp8e	153	15	to	to	TO
cord-258536-qnn9hp8e	153	16	better	better	RB
cord-258536-qnn9hp8e	153	17	understand	understand	VB
cord-258536-qnn9hp8e	153	18	the	the	DT
cord-258536-qnn9hp8e	153	19	impact	impact	NN
cord-258536-qnn9hp8e	153	20	of	of	IN
cord-258536-qnn9hp8e	153	21	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	153	22	on	on	IN
cord-258536-qnn9hp8e	153	23	host	host	NN
cord-258536-qnn9hp8e	153	24	cells	cell	NNS
cord-258536-qnn9hp8e	153	25	.	.	.
cord-258536-qnn9hp8e	154	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	154	2	they	-PRON-	PRP
cord-258536-qnn9hp8e	154	3	found	find	VBD
cord-258536-qnn9hp8e	154	4	that	that	IN
cord-258536-qnn9hp8e	154	5	autophagy	autophagy	NN
cord-258536-qnn9hp8e	154	6	might	may	MD
cord-258536-qnn9hp8e	154	7	be	be	VB
cord-258536-qnn9hp8e	154	8	among	among	IN
cord-258536-qnn9hp8e	154	9	the	the	DT
cord-258536-qnn9hp8e	154	10	altered	altered	JJ
cord-258536-qnn9hp8e	154	11	pathways	pathway	NNS
cord-258536-qnn9hp8e	154	12	as	as	IN
cord-258536-qnn9hp8e	154	13	sequestrosome	sequestrosome	NNP
cord-258536-qnn9hp8e	154	14	1	1	CD
cord-258536-qnn9hp8e	154	15	(	(	-LRB-
cord-258536-qnn9hp8e	154	16	SQTSM1	sqtsm1	NN
cord-258536-qnn9hp8e	154	17	/	/	SYM
cord-258536-qnn9hp8e	154	18	p62	p62	NN
cord-258536-qnn9hp8e	154	19	)	)	-RRB-
cord-258536-qnn9hp8e	154	20	and	and	CC
cord-258536-qnn9hp8e	154	21	LC3	lc3	JJ
cord-258536-qnn9hp8e	154	22	expression	expression	NN
cord-258536-qnn9hp8e	154	23	levels	level	NNS
cord-258536-qnn9hp8e	154	24	were	be	VBD
cord-258536-qnn9hp8e	154	25	upregulated	upregulate	VBN
cord-258536-qnn9hp8e	154	26	.	.	.
cord-258536-qnn9hp8e	155	1	A	a	DT
cord-258536-qnn9hp8e	155	2	subsequent	subsequent	JJ
cord-258536-qnn9hp8e	155	3	study	study	NN
cord-258536-qnn9hp8e	155	4	thus	thus	RB
cord-258536-qnn9hp8e	155	5	focused	focus	VBD
cord-258536-qnn9hp8e	155	6	on	on	IN
cord-258536-qnn9hp8e	155	7	the	the	DT
cord-258536-qnn9hp8e	155	8	potential	potential	JJ
cord-258536-qnn9hp8e	155	9	interplay	interplay	NN
cord-258536-qnn9hp8e	155	10	between	between	IN
cord-258536-qnn9hp8e	155	11	autophagy	autophagy	NN
cord-258536-qnn9hp8e	155	12	and	and	CC
cord-258536-qnn9hp8e	155	13	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	155	14	[	[	-LRB-
cord-258536-qnn9hp8e	155	15	77	77	CD
cord-258536-qnn9hp8e	155	16	]	]	-RRB-
cord-258536-qnn9hp8e	155	17	.	.	.
cord-258536-qnn9hp8e	156	1	The	the	DT
cord-258536-qnn9hp8e	156	2	authors	author	NNS
cord-258536-qnn9hp8e	156	3	found	find	VBD
cord-258536-qnn9hp8e	156	4	that	that	IN
cord-258536-qnn9hp8e	156	5	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	156	6	infection	infection	NN
cord-258536-qnn9hp8e	156	7	induces	induce	VBZ
cord-258536-qnn9hp8e	156	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	156	9	in	in	IN
cord-258536-qnn9hp8e	156	10	Vero	Vero	NNP
cord-258536-qnn9hp8e	156	11	cells	cell	NNS
cord-258536-qnn9hp8e	156	12	using	use	VBG
cord-258536-qnn9hp8e	156	13	different	different	JJ
cord-258536-qnn9hp8e	156	14	assays	assay	NNS
cord-258536-qnn9hp8e	156	15	such	such	JJ
cord-258536-qnn9hp8e	156	16	as	as	IN
cord-258536-qnn9hp8e	156	17	LC3-positive	lc3-positive	JJ
cord-258536-qnn9hp8e	156	18	puncta	puncta	NN
cord-258536-qnn9hp8e	156	19	formation	formation	NN
cord-258536-qnn9hp8e	156	20	,	,	,
cord-258536-qnn9hp8e	156	21	transmission	transmission	NN
cord-258536-qnn9hp8e	156	22	electron	electron	NN
cord-258536-qnn9hp8e	156	23	microscopy	microscopy	NN
cord-258536-qnn9hp8e	156	24	(	(	-LRB-
cord-258536-qnn9hp8e	156	25	TEM	TEM	NNP
cord-258536-qnn9hp8e	156	26	)	)	-RRB-
cord-258536-qnn9hp8e	156	27	and	and	CC
cord-258536-qnn9hp8e	156	28	western	western	JJ
cord-258536-qnn9hp8e	156	29	blot	blot	NN
cord-258536-qnn9hp8e	156	30	assessment	assessment	NN
cord-258536-qnn9hp8e	156	31	of	of	IN
cord-258536-qnn9hp8e	156	32	both	both	DT
cord-258536-qnn9hp8e	156	33	LC3	lc3	JJ
cord-258536-qnn9hp8e	156	34	lipidation	lipidation	NN
cord-258536-qnn9hp8e	156	35	and	and	CC
cord-258536-qnn9hp8e	156	36	SQSTM1	sqstm1	NN
cord-258536-qnn9hp8e	156	37	/	/	SYM
cord-258536-qnn9hp8e	156	38	p62	p62	NN
cord-258536-qnn9hp8e	156	39	turnover	turnover	NN
cord-258536-qnn9hp8e	156	40	.	.	.
cord-258536-qnn9hp8e	157	1	In	in	IN
cord-258536-qnn9hp8e	157	2	line	line	NN
cord-258536-qnn9hp8e	157	3	with	with	IN
cord-258536-qnn9hp8e	157	4	these	these	DT
cord-258536-qnn9hp8e	157	5	observations	observation	NNS
cord-258536-qnn9hp8e	157	6	,	,	,
cord-258536-qnn9hp8e	157	7	3-MA	3-ma	CD
cord-258536-qnn9hp8e	157	8	treatment	treatment	NN
cord-258536-qnn9hp8e	157	9	or	or	CC
cord-258536-qnn9hp8e	157	10	the	the	DT
cord-258536-qnn9hp8e	157	11	ablation	ablation	NN
cord-258536-qnn9hp8e	157	12	of	of	IN
cord-258536-qnn9hp8e	157	13	either	either	DT
cord-258536-qnn9hp8e	157	14	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	157	15	or	or	CC
cord-258536-qnn9hp8e	157	16	ATG7	ATG7	NNP
cord-258536-qnn9hp8e	157	17	,	,	,
cord-258536-qnn9hp8e	157	18	reduced	reduce	VBD
cord-258536-qnn9hp8e	157	19	the	the	DT
cord-258536-qnn9hp8e	157	20	production	production	NN
cord-258536-qnn9hp8e	157	21	of	of	IN
cord-258536-qnn9hp8e	157	22	infectious	infectious	JJ
cord-258536-qnn9hp8e	157	23	viral	viral	JJ
cord-258536-qnn9hp8e	157	24	particles	particle	NNS
cord-258536-qnn9hp8e	157	25	.	.	.
cord-258536-qnn9hp8e	158	1	Treatment	treatment	NN
cord-258536-qnn9hp8e	158	2	of	of	IN
cord-258536-qnn9hp8e	158	3	the	the	DT
cord-258536-qnn9hp8e	158	4	infected	infected	JJ
cord-258536-qnn9hp8e	158	5	cells	cell	NNS
cord-258536-qnn9hp8e	158	6	with	with	IN
cord-258536-qnn9hp8e	158	7	rapamycin	rapamycin	NNS
cord-258536-qnn9hp8e	158	8	,	,	,
cord-258536-qnn9hp8e	158	9	however	however	RB
cord-258536-qnn9hp8e	158	10	,	,	,
cord-258536-qnn9hp8e	158	11	did	do	VBD
cord-258536-qnn9hp8e	158	12	not	not	RB
cord-258536-qnn9hp8e	158	13	change	change	VB
cord-258536-qnn9hp8e	158	14	the	the	DT
cord-258536-qnn9hp8e	158	15	viral	viral	JJ
cord-258536-qnn9hp8e	158	16	titer	titer	NN
cord-258536-qnn9hp8e	158	17	,	,	,
cord-258536-qnn9hp8e	158	18	probably	probably	RB
cord-258536-qnn9hp8e	158	19	because	because	IN
cord-258536-qnn9hp8e	158	20	of	of	IN
cord-258536-qnn9hp8e	158	21	the	the	DT
cord-258536-qnn9hp8e	158	22	multiple	multiple	JJ
cord-258536-qnn9hp8e	158	23	effects	effect	NNS
cord-258536-qnn9hp8e	158	24	of	of	IN
cord-258536-qnn9hp8e	158	25	this	this	DT
cord-258536-qnn9hp8e	158	26	compound	compound	NN
cord-258536-qnn9hp8e	158	27	on	on	IN
cord-258536-qnn9hp8e	158	28	the	the	DT
cord-258536-qnn9hp8e	158	29	cell	cell	NN
cord-258536-qnn9hp8e	158	30	physiology	physiology	NN
cord-258536-qnn9hp8e	158	31	.	.	.
cord-258536-qnn9hp8e	159	1	Altogether	altogether	RB
cord-258536-qnn9hp8e	159	2	,	,	,
cord-258536-qnn9hp8e	159	3	these	these	DT
cord-258536-qnn9hp8e	159	4	data	datum	NNS
cord-258536-qnn9hp8e	159	5	showed	show	VBD
cord-258536-qnn9hp8e	159	6	that	that	IN
cord-258536-qnn9hp8e	159	7	autophagy	autophagy	NN
cord-258536-qnn9hp8e	159	8	induction	induction	NN
cord-258536-qnn9hp8e	159	9	during	during	IN
cord-258536-qnn9hp8e	159	10	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	159	11	infection	infection	NN
cord-258536-qnn9hp8e	159	12	could	could	MD
cord-258536-qnn9hp8e	159	13	be	be	VB
cord-258536-qnn9hp8e	159	14	beneficial	beneficial	JJ
cord-258536-qnn9hp8e	159	15	for	for	IN
cord-258536-qnn9hp8e	159	16	the	the	DT
cord-258536-qnn9hp8e	159	17	virus	virus	NN
cord-258536-qnn9hp8e	159	18	.	.	.
cord-258536-qnn9hp8e	160	1	Two	two	CD
cord-258536-qnn9hp8e	160	2	more	more	JJR
cord-258536-qnn9hp8e	160	3	recent	recent	JJ
cord-258536-qnn9hp8e	160	4	studies	study	NNS
cord-258536-qnn9hp8e	160	5	have	have	VBP
cord-258536-qnn9hp8e	160	6	addressed	address	VBN
cord-258536-qnn9hp8e	160	7	the	the	DT
cord-258536-qnn9hp8e	160	8	link	link	NN
cord-258536-qnn9hp8e	160	9	between	between	IN
cord-258536-qnn9hp8e	160	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	160	11	and	and	CC
cord-258536-qnn9hp8e	160	12	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	160	13	replication	replication	NN
cord-258536-qnn9hp8e	161	1	but	but	CC
cord-258536-qnn9hp8e	161	2	they	-PRON-	PRP
cord-258536-qnn9hp8e	161	3	have	have	VBP
cord-258536-qnn9hp8e	161	4	reached	reach	VBN
cord-258536-qnn9hp8e	161	5	opposite	opposite	JJ
cord-258536-qnn9hp8e	161	6	conclusions	conclusion	NNS
cord-258536-qnn9hp8e	161	7	[	[	-LRB-
cord-258536-qnn9hp8e	161	8	78	78	CD
cord-258536-qnn9hp8e	161	9	,	,	,
cord-258536-qnn9hp8e	161	10	79	79	CD
cord-258536-qnn9hp8e	161	11	]	]	-RRB-
cord-258536-qnn9hp8e	161	12	.	.	.
cord-258536-qnn9hp8e	162	1	They	-PRON-	PRP
cord-258536-qnn9hp8e	162	2	both	both	DT
cord-258536-qnn9hp8e	162	3	demonstrated	demonstrate	VBD
cord-258536-qnn9hp8e	162	4	that	that	IN
cord-258536-qnn9hp8e	162	5	autophagy	autophagy	NN
cord-258536-qnn9hp8e	162	6	is	be	VBZ
cord-258536-qnn9hp8e	162	7	induced	induce	VBN
cord-258536-qnn9hp8e	162	8	in	in	IN
cord-258536-qnn9hp8e	162	9	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	162	10	-	-	HYPH
cord-258536-qnn9hp8e	162	11	infected	infect	VBN
cord-258536-qnn9hp8e	162	12	cells	cell	NNS
cord-258536-qnn9hp8e	162	13	using	use	VBG
cord-258536-qnn9hp8e	162	14	methods	method	NNS
cord-258536-qnn9hp8e	162	15	such	such	JJ
cord-258536-qnn9hp8e	162	16	as	as	IN
cord-258536-qnn9hp8e	162	17	TEM	TEM	NNP
cord-258536-qnn9hp8e	162	18	,	,	,
cord-258536-qnn9hp8e	162	19	LC3	lc3	JJ
cord-258536-qnn9hp8e	162	20	puncta	puncta	NN
cord-258536-qnn9hp8e	162	21	formation	formation	NN
cord-258536-qnn9hp8e	162	22	and	and	CC
cord-258536-qnn9hp8e	162	23	western	western	JJ
cord-258536-qnn9hp8e	162	24	blot	blot	NN
cord-258536-qnn9hp8e	162	25	analysis	analysis	NN
cord-258536-qnn9hp8e	162	26	of	of	IN
cord-258536-qnn9hp8e	162	27	both	both	DT
cord-258536-qnn9hp8e	162	28	LC3	lc3	JJ
cord-258536-qnn9hp8e	162	29	lipidation	lipidation	NN
cord-258536-qnn9hp8e	162	30	and	and	CC
cord-258536-qnn9hp8e	162	31	SQSTM1	sqstm1	NN
cord-258536-qnn9hp8e	162	32	/	/	SYM
cord-258536-qnn9hp8e	162	33	p62	p62	NN
cord-258536-qnn9hp8e	162	34	degradation	degradation	NN
cord-258536-qnn9hp8e	162	35	.	.	.
cord-258536-qnn9hp8e	163	1	In	in	IN
cord-258536-qnn9hp8e	163	2	their	-PRON-	PRP$
cord-258536-qnn9hp8e	163	3	article	article	NN
cord-258536-qnn9hp8e	163	4	Zhu	Zhu	NNP
cord-258536-qnn9hp8e	163	5	et	et	FW
cord-258536-qnn9hp8e	163	6	al	al	NNP
cord-258536-qnn9hp8e	163	7	.	.	.
cord-258536-qnn9hp8e	163	8	also	also	RB
cord-258536-qnn9hp8e	163	9	showed	show	VBD
cord-258536-qnn9hp8e	163	10	that	that	IN
cord-258536-qnn9hp8e	163	11	the	the	DT
cord-258536-qnn9hp8e	163	12	selective	selective	JJ
cord-258536-qnn9hp8e	163	13	degradation	degradation	NN
cord-258536-qnn9hp8e	163	14	of	of	IN
cord-258536-qnn9hp8e	163	15	mitochondria	mitochondrion	NNS
cord-258536-qnn9hp8e	163	16	by	by	IN
cord-258536-qnn9hp8e	163	17	autophagy	autophagy	NN
cord-258536-qnn9hp8e	163	18	,	,	,
cord-258536-qnn9hp8e	163	19	i.e.	i.e.	FW
cord-258536-qnn9hp8e	163	20	mitophagy	mitophagy	NN
cord-258536-qnn9hp8e	163	21	,	,	,
cord-258536-qnn9hp8e	163	22	might	may	MD
cord-258536-qnn9hp8e	163	23	be	be	VB
cord-258536-qnn9hp8e	163	24	induced	induce	VBN
cord-258536-qnn9hp8e	163	25	by	by	IN
cord-258536-qnn9hp8e	163	26	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	163	27	as	as	IN
cord-258536-qnn9hp8e	163	28	they	-PRON-	PRP
cord-258536-qnn9hp8e	163	29	observed	observe	VBD
cord-258536-qnn9hp8e	163	30	in	in	IN
cord-258536-qnn9hp8e	163	31	infected	infected	JJ
cord-258536-qnn9hp8e	163	32	IPEC	IPEC	NNP
cord-258536-qnn9hp8e	163	33	-	-	HYPH
cord-258536-qnn9hp8e	163	34	J2	j2	NN
cord-258536-qnn9hp8e	163	35	cells	cell	VBZ
cord-258536-qnn9hp8e	163	36	a	a	DT
cord-258536-qnn9hp8e	163	37	reduced	reduce	VBN
cord-258536-qnn9hp8e	163	38	mitochondrial	mitochondrial	NN
cord-258536-qnn9hp8e	163	39	mass	mass	NN
cord-258536-qnn9hp8e	163	40	,	,	,
cord-258536-qnn9hp8e	163	41	a	a	DT
cord-258536-qnn9hp8e	163	42	light	light	JJ
cord-258536-qnn9hp8e	163	43	oxidative	oxidative	JJ
cord-258536-qnn9hp8e	163	44	stress	stress	NN
cord-258536-qnn9hp8e	163	45	,	,	,
cord-258536-qnn9hp8e	163	46	and	and	CC
cord-258536-qnn9hp8e	163	47	mitochondria	mitochondrion	NNS
cord-258536-qnn9hp8e	163	48	in	in	IN
cord-258536-qnn9hp8e	163	49	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	163	50	-	-	HYPH
cord-258536-qnn9hp8e	163	51	like	like	JJ
cord-258536-qnn9hp8e	163	52	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	163	53	[	[	-LRB-
cord-258536-qnn9hp8e	163	54	79	79	CD
cord-258536-qnn9hp8e	163	55	]	]	-RRB-
cord-258536-qnn9hp8e	163	56	.	.	.
cord-258536-qnn9hp8e	164	1	In	in	IN
cord-258536-qnn9hp8e	164	2	support	support	NN
cord-258536-qnn9hp8e	164	3	of	of	IN
cord-258536-qnn9hp8e	164	4	this	this	DT
cord-258536-qnn9hp8e	164	5	notion	notion	NN
cord-258536-qnn9hp8e	164	6	,	,	,
cord-258536-qnn9hp8e	164	7	the	the	DT
cord-258536-qnn9hp8e	164	8	authors	author	NNS
cord-258536-qnn9hp8e	164	9	also	also	RB
cord-258536-qnn9hp8e	164	10	found	find	VBD
cord-258536-qnn9hp8e	164	11	that	that	IN
cord-258536-qnn9hp8e	164	12	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	164	13	N	n	CD
cord-258536-qnn9hp8e	164	14	protein	protein	NN
cord-258536-qnn9hp8e	164	15	and	and	CC
cord-258536-qnn9hp8e	164	16	GFP	GFP	NNP
cord-258536-qnn9hp8e	164	17	-	-	HYPH
cord-258536-qnn9hp8e	164	18	LC3	lc3	NN
cord-258536-qnn9hp8e	164	19	localize	localize	VBP
cord-258536-qnn9hp8e	164	20	to	to	IN
cord-258536-qnn9hp8e	164	21	mitochondria	mitochondrion	NNS
cord-258536-qnn9hp8e	164	22	.	.	.
cord-258536-qnn9hp8e	165	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	165	2	,	,	,
cord-258536-qnn9hp8e	165	3	induction	induction	NN
cord-258536-qnn9hp8e	165	4	of	of	IN
cord-258536-qnn9hp8e	165	5	mitophagy	mitophagy	NNP
cord-258536-qnn9hp8e	165	6	by	by	IN
cord-258536-qnn9hp8e	165	7	mitochondria	mitochondrion	NNS
cord-258536-qnn9hp8e	165	8	depolarization	depolarization	NN
cord-258536-qnn9hp8e	165	9	using	use	VBG
cord-258536-qnn9hp8e	165	10	carbonyl	carbonyl	NN
cord-258536-qnn9hp8e	165	11	cyanide	cyanide	NN
cord-258536-qnn9hp8e	165	12	m	m	NNP
cord-258536-qnn9hp8e	165	13	-	-	HYPH
cord-258536-qnn9hp8e	165	14	chlorophenyl	chlorophenyl	NNP
cord-258536-qnn9hp8e	165	15	hydrazone	hydrazone	NNP
cord-258536-qnn9hp8e	165	16	(	(	-LRB-
cord-258536-qnn9hp8e	165	17	CCCP	CCCP	NNP
cord-258536-qnn9hp8e	165	18	)	)	-RRB-
cord-258536-qnn9hp8e	165	19	increased	increase	VBD
cord-258536-qnn9hp8e	165	20	the	the	DT
cord-258536-qnn9hp8e	165	21	viral	viral	JJ
cord-258536-qnn9hp8e	165	22	titer	titer	NN
cord-258536-qnn9hp8e	165	23	,	,	,
cord-258536-qnn9hp8e	165	24	suggesting	suggest	VBG
cord-258536-qnn9hp8e	165	25	that	that	IN
cord-258536-qnn9hp8e	165	26	this	this	DT
cord-258536-qnn9hp8e	165	27	pathway	pathway	NN
cord-258536-qnn9hp8e	165	28	might	may	MD
cord-258536-qnn9hp8e	165	29	be	be	VB
cord-258536-qnn9hp8e	165	30	beneficial	beneficial	JJ
cord-258536-qnn9hp8e	165	31	for	for	IN
cord-258536-qnn9hp8e	165	32	viral	viral	JJ
cord-258536-qnn9hp8e	165	33	replication	replication	NN
cord-258536-qnn9hp8e	165	34	.	.	.
cord-258536-qnn9hp8e	166	1	Similarly	similarly	RB
cord-258536-qnn9hp8e	166	2	,	,	,
cord-258536-qnn9hp8e	166	3	induction	induction	NN
cord-258536-qnn9hp8e	166	4	of	of	IN
cord-258536-qnn9hp8e	166	5	bulk	bulk	JJ
cord-258536-qnn9hp8e	166	6	autophagy	autophagy	NN
cord-258536-qnn9hp8e	166	7	using	use	VBG
cord-258536-qnn9hp8e	166	8	rapamycin	rapamycin	NNS
cord-258536-qnn9hp8e	166	9	also	also	RB
cord-258536-qnn9hp8e	166	10	led	lead	VBD
cord-258536-qnn9hp8e	166	11	to	to	IN
cord-258536-qnn9hp8e	166	12	more	more	JJR
cord-258536-qnn9hp8e	166	13	production	production	NN
cord-258536-qnn9hp8e	166	14	of	of	IN
cord-258536-qnn9hp8e	166	15	progeny	progeny	JJ
cord-258536-qnn9hp8e	166	16	virus	virus	NN
cord-258536-qnn9hp8e	166	17	[	[	-LRB-
cord-258536-qnn9hp8e	166	18	79	79	CD
cord-258536-qnn9hp8e	166	19	]	]	-RRB-
cord-258536-qnn9hp8e	166	20	.	.	.
cord-258536-qnn9hp8e	167	1	Conversely	conversely	RB
cord-258536-qnn9hp8e	167	2	,	,	,
cord-258536-qnn9hp8e	167	3	incubation	incubation	NN
cord-258536-qnn9hp8e	167	4	with	with	IN
cord-258536-qnn9hp8e	167	5	3-MA	3-ma	CD
cord-258536-qnn9hp8e	167	6	or	or	CC
cord-258536-qnn9hp8e	167	7	ATG5	atg5	JJ
cord-258536-qnn9hp8e	167	8	depletion	depletion	NN
cord-258536-qnn9hp8e	167	9	inhibited	inhibit	VBN
cord-258536-qnn9hp8e	167	10	viral	viral	JJ
cord-258536-qnn9hp8e	167	11	replication	replication	NN
cord-258536-qnn9hp8e	167	12	assessed	assess	VBN
cord-258536-qnn9hp8e	167	13	by	by	IN
cord-258536-qnn9hp8e	167	14	N	n	CD
cord-258536-qnn9hp8e	167	15	protein	protein	NN
cord-258536-qnn9hp8e	167	16	expression	expression	NN
cord-258536-qnn9hp8e	167	17	and	and	CC
cord-258536-qnn9hp8e	167	18	viral	viral	JJ
cord-258536-qnn9hp8e	167	19	titers	titer	NNS
cord-258536-qnn9hp8e	167	20	.	.	.
cord-258536-qnn9hp8e	168	1	Zhu	Zhu	NNP
cord-258536-qnn9hp8e	168	2	et	et	FW
cord-258536-qnn9hp8e	168	3	al	al	NNP
cord-258536-qnn9hp8e	168	4	.	.	.
cord-258536-qnn9hp8e	169	1	thus	thus	RB
cord-258536-qnn9hp8e	169	2	concluded	conclude	VBD
cord-258536-qnn9hp8e	169	3	that	that	IN
cord-258536-qnn9hp8e	169	4	autophagy	autophagy	NN
cord-258536-qnn9hp8e	169	5	,	,	,
cord-258536-qnn9hp8e	169	6	and	and	CC
cord-258536-qnn9hp8e	169	7	mitophagy	mitophagy	NN
cord-258536-qnn9hp8e	169	8	in	in	IN
cord-258536-qnn9hp8e	169	9	particular	particular	JJ
cord-258536-qnn9hp8e	169	10	,	,	,
cord-258536-qnn9hp8e	169	11	plays	play	VBZ
cord-258536-qnn9hp8e	169	12	an	an	DT
cord-258536-qnn9hp8e	169	13	important	important	JJ
cord-258536-qnn9hp8e	169	14	role	role	NN
cord-258536-qnn9hp8e	169	15	in	in	IN
cord-258536-qnn9hp8e	169	16	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	169	17	life	life	NN
cord-258536-qnn9hp8e	169	18	cycle	cycle	NN
cord-258536-qnn9hp8e	169	19	[	[	-LRB-
cord-258536-qnn9hp8e	169	20	79	79	CD
cord-258536-qnn9hp8e	169	21	]	]	-RRB-
cord-258536-qnn9hp8e	169	22	.	.	.
cord-258536-qnn9hp8e	170	1	This	this	DT
cord-258536-qnn9hp8e	170	2	conclusion	conclusion	NN
cord-258536-qnn9hp8e	170	3	,	,	,
cord-258536-qnn9hp8e	170	4	however	however	RB
cord-258536-qnn9hp8e	170	5	,	,	,
cord-258536-qnn9hp8e	170	6	differs	differ	VBZ
cord-258536-qnn9hp8e	170	7	from	from	IN
cord-258536-qnn9hp8e	170	8	the	the	DT
cord-258536-qnn9hp8e	170	9	one	one	CD
cord-258536-qnn9hp8e	170	10	reached	reach	VBN
cord-258536-qnn9hp8e	170	11	in	in	IN
cord-258536-qnn9hp8e	170	12	a	a	DT
cord-258536-qnn9hp8e	170	13	parallel	parallel	JJ
cord-258536-qnn9hp8e	170	14	study	study	NN
cord-258536-qnn9hp8e	170	15	.	.	.
cord-258536-qnn9hp8e	171	1	Guo	Guo	NNP
cord-258536-qnn9hp8e	171	2	and	and	CC
cord-258536-qnn9hp8e	171	3	collaborators	collaborator	NNS
cord-258536-qnn9hp8e	171	4	found	find	VBD
cord-258536-qnn9hp8e	171	5	that	that	IN
cord-258536-qnn9hp8e	171	6	both	both	DT
cord-258536-qnn9hp8e	171	7	hVPS34	hVPS34	NNP
cord-258536-qnn9hp8e	171	8	and	and	CC
cord-258536-qnn9hp8e	171	9	lysosomal	lysosomal	JJ
cord-258536-qnn9hp8e	171	10	inhibitors	inhibitor	NNS
cord-258536-qnn9hp8e	171	11	increased	increase	VBD
cord-258536-qnn9hp8e	171	12	both	both	CC
cord-258536-qnn9hp8e	171	13	the	the	DT
cord-258536-qnn9hp8e	171	14	number	number	NN
cord-258536-qnn9hp8e	171	15	of	of	IN
cord-258536-qnn9hp8e	171	16	cells	cell	NNS
cord-258536-qnn9hp8e	171	17	infected	infect	VBN
cord-258536-qnn9hp8e	171	18	by	by	IN
cord-258536-qnn9hp8e	171	19	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	171	20	and	and	CC
cord-258536-qnn9hp8e	171	21	the	the	DT
cord-258536-qnn9hp8e	171	22	viral	viral	JJ
cord-258536-qnn9hp8e	171	23	titer	titer	NN
cord-258536-qnn9hp8e	171	24	,	,	,
cord-258536-qnn9hp8e	171	25	while	while	IN
cord-258536-qnn9hp8e	171	26	rapamycin	rapamycin	NNP
cord-258536-qnn9hp8e	171	27	had	have	VBD
cord-258536-qnn9hp8e	171	28	an	an	DT
cord-258536-qnn9hp8e	171	29	opposite	opposite	JJ
cord-258536-qnn9hp8e	171	30	effect	effect	NN
cord-258536-qnn9hp8e	171	31	[	[	-LRB-
cord-258536-qnn9hp8e	171	32	78	78	CD
cord-258536-qnn9hp8e	171	33	]	]	-RRB-
cord-258536-qnn9hp8e	171	34	.	.	.
cord-258536-qnn9hp8e	172	1	Moreover	moreover	RB
cord-258536-qnn9hp8e	172	2	,	,	,
cord-258536-qnn9hp8e	172	3	silencing	silence	VBG
cord-258536-qnn9hp8e	172	4	LC3	lc3	NN
cord-258536-qnn9hp8e	172	5	,	,	,
cord-258536-qnn9hp8e	172	6	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	172	7	,	,	,
cord-258536-qnn9hp8e	172	8	or	or	CC
cord-258536-qnn9hp8e	172	9	ATG7	ATG7	NNP
cord-258536-qnn9hp8e	172	10	expression	expression	NN
cord-258536-qnn9hp8e	172	11	in	in	IN
cord-258536-qnn9hp8e	172	12	ST	ST	NNP
cord-258536-qnn9hp8e	172	13	cells	cell	NNS
cord-258536-qnn9hp8e	172	14	promoted	promote	VBD
cord-258536-qnn9hp8e	172	15	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	172	16	replication	replication	NN
cord-258536-qnn9hp8e	172	17	,	,	,
cord-258536-qnn9hp8e	172	18	showing	show	VBG
cord-258536-qnn9hp8e	172	19	that	that	IN
cord-258536-qnn9hp8e	172	20	autophagy	autophagy	NN
cord-258536-qnn9hp8e	172	21	has	have	VBZ
cord-258536-qnn9hp8e	172	22	an	an	DT
cord-258536-qnn9hp8e	172	23	antiviral	antiviral	JJ
cord-258536-qnn9hp8e	172	24	function	function	NN
cord-258536-qnn9hp8e	172	25	[	[	-LRB-
cord-258536-qnn9hp8e	172	26	78	78	CD
cord-258536-qnn9hp8e	172	27	]	]	-RRB-
cord-258536-qnn9hp8e	172	28	.	.	.
cord-258536-qnn9hp8e	173	1	The	the	DT
cord-258536-qnn9hp8e	173	2	apparent	apparent	JJ
cord-258536-qnn9hp8e	173	3	discrepancies	discrepancy	NNS
cord-258536-qnn9hp8e	173	4	between	between	IN
cord-258536-qnn9hp8e	173	5	these	these	DT
cord-258536-qnn9hp8e	173	6	two	two	CD
cord-258536-qnn9hp8e	173	7	studies	study	NNS
cord-258536-qnn9hp8e	173	8	could	could	MD
cord-258536-qnn9hp8e	173	9	be	be	VB
cord-258536-qnn9hp8e	173	10	explained	explain	VBN
cord-258536-qnn9hp8e	173	11	by	by	IN
cord-258536-qnn9hp8e	173	12	the	the	DT
cord-258536-qnn9hp8e	173	13	use	use	NN
cord-258536-qnn9hp8e	173	14	of	of	IN
cord-258536-qnn9hp8e	173	15	different	different	JJ
cord-258536-qnn9hp8e	173	16	TGEV	TGEV	NNS
cord-258536-qnn9hp8e	173	17	strains	strain	NNS
cord-258536-qnn9hp8e	173	18	(	(	-LRB-
cord-258536-qnn9hp8e	173	19	SHXB	SHXB	NNP
cord-258536-qnn9hp8e	173	20	versus	versus	IN
cord-258536-qnn9hp8e	173	21	H165	H165	NNP
cord-258536-qnn9hp8e	173	22	)	)	-RRB-
cord-258536-qnn9hp8e	173	23	and/or	and/or	CC
cord-258536-qnn9hp8e	173	24	cell	cell	NN
cord-258536-qnn9hp8e	173	25	lines	line	NNS
cord-258536-qnn9hp8e	173	26	(	(	-LRB-
cord-258536-qnn9hp8e	173	27	IPEC	IPEC	NNP
cord-258536-qnn9hp8e	173	28	-	-	HYPH
cord-258536-qnn9hp8e	173	29	J2	J2	NNP
cord-258536-qnn9hp8e	173	30	versus	versus	IN
cord-258536-qnn9hp8e	173	31	ST	ST	NNP
cord-258536-qnn9hp8e	173	32	)	)	-RRB-
cord-258536-qnn9hp8e	173	33	.	.	.
cord-258536-qnn9hp8e	174	1	Further	further	JJ
cord-258536-qnn9hp8e	174	2	investigations	investigation	NNS
cord-258536-qnn9hp8e	174	3	are	be	VBP
cord-258536-qnn9hp8e	174	4	thus	thus	RB
cord-258536-qnn9hp8e	174	5	needed	need	VBN
cord-258536-qnn9hp8e	174	6	to	to	TO
cord-258536-qnn9hp8e	174	7	conclusively	conclusively	RB
cord-258536-qnn9hp8e	174	8	determine	determine	VB
cord-258536-qnn9hp8e	174	9	whether	whether	IN
cord-258536-qnn9hp8e	174	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	174	11	plays	play	VBZ
cord-258536-qnn9hp8e	174	12	a	a	DT
cord-258536-qnn9hp8e	174	13	role	role	NN
cord-258536-qnn9hp8e	174	14	in	in	IN
cord-258536-qnn9hp8e	174	15	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	174	16	life	life	NN
cord-258536-qnn9hp8e	174	17	cycle	cycle	NN
cord-258536-qnn9hp8e	174	18	.	.	.
cord-258536-qnn9hp8e	175	1	It	-PRON-	PRP
cord-258536-qnn9hp8e	175	2	will	will	MD
cord-258536-qnn9hp8e	175	3	be	be	VB
cord-258536-qnn9hp8e	175	4	particularly	particularly	RB
cord-258536-qnn9hp8e	175	5	important	important	JJ
cord-258536-qnn9hp8e	175	6	to	to	TO
cord-258536-qnn9hp8e	175	7	establish	establish	VB
cord-258536-qnn9hp8e	175	8	this	this	DT
cord-258536-qnn9hp8e	175	9	in	in	IN
cord-258536-qnn9hp8e	175	10	tissues	tissue	NNS
cord-258536-qnn9hp8e	175	11	that	that	WDT
cord-258536-qnn9hp8e	175	12	are	be	VBP
cord-258536-qnn9hp8e	175	13	normally	normally	RB
cord-258536-qnn9hp8e	175	14	infected	infect	VBN
cord-258536-qnn9hp8e	175	15	by	by	IN
cord-258536-qnn9hp8e	175	16	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	175	17	.	.	.
cord-258536-qnn9hp8e	176	1	The	the	DT
cord-258536-qnn9hp8e	176	2	first	first	JJ
cord-258536-qnn9hp8e	176	3	investigations	investigation	NNS
cord-258536-qnn9hp8e	176	4	on	on	IN
cord-258536-qnn9hp8e	176	5	the	the	DT
cord-258536-qnn9hp8e	176	6	interplay	interplay	NN
cord-258536-qnn9hp8e	176	7	between	between	IN
cord-258536-qnn9hp8e	176	8	CoV	cov	NN
cord-258536-qnn9hp8e	176	9	and	and	CC
cord-258536-qnn9hp8e	176	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	176	11	focused	focus	VBN
cord-258536-qnn9hp8e	176	12	on	on	IN
cord-258536-qnn9hp8e	176	13	MHV	MHV	NNP
cord-258536-qnn9hp8e	176	14	,	,	,
cord-258536-qnn9hp8e	176	15	a	a	DT
cord-258536-qnn9hp8e	176	16	betacoronavirus	betacoronavirus	NN
cord-258536-qnn9hp8e	176	17	(	(	-LRB-
cord-258536-qnn9hp8e	176	18	beta	beta	NN
cord-258536-qnn9hp8e	176	19	-	-	HYPH
cord-258536-qnn9hp8e	176	20	CoV	cov	NN
cord-258536-qnn9hp8e	176	21	)	)	-RRB-
cord-258536-qnn9hp8e	176	22	that	that	WDT
cord-258536-qnn9hp8e	176	23	is	be	VBZ
cord-258536-qnn9hp8e	176	24	often	often	RB
cord-258536-qnn9hp8e	176	25	used	use	VBN
cord-258536-qnn9hp8e	176	26	as	as	IN
cord-258536-qnn9hp8e	176	27	a	a	DT
cord-258536-qnn9hp8e	176	28	model	model	NN
cord-258536-qnn9hp8e	176	29	virus	virus	NN
cord-258536-qnn9hp8e	176	30	to	to	TO
cord-258536-qnn9hp8e	176	31	study	study	VB
cord-258536-qnn9hp8e	176	32	the	the	DT
cord-258536-qnn9hp8e	176	33	mechanism	mechanism	NN
cord-258536-qnn9hp8e	176	34	of	of	IN
cord-258536-qnn9hp8e	176	35	CoV	CoV	NNP
cord-258536-qnn9hp8e	176	36	infections	infection	NNS
cord-258536-qnn9hp8e	176	37	.	.	.
cord-258536-qnn9hp8e	177	1	As	as	IN
cord-258536-qnn9hp8e	177	2	a	a	DT
cord-258536-qnn9hp8e	177	3	result	result	NN
cord-258536-qnn9hp8e	177	4	,	,	,
cord-258536-qnn9hp8e	177	5	there	there	EX
cord-258536-qnn9hp8e	177	6	is	be	VBZ
cord-258536-qnn9hp8e	177	7	a	a	DT
cord-258536-qnn9hp8e	177	8	relatively	relatively	RB
cord-258536-qnn9hp8e	177	9	large	large	JJ
cord-258536-qnn9hp8e	177	10	amount	amount	NN
cord-258536-qnn9hp8e	177	11	of	of	IN
cord-258536-qnn9hp8e	177	12	data	datum	NNS
cord-258536-qnn9hp8e	177	13	about	about	IN
cord-258536-qnn9hp8e	177	14	various	various	JJ
cord-258536-qnn9hp8e	177	15	aspects	aspect	NNS
cord-258536-qnn9hp8e	177	16	of	of	IN
cord-258536-qnn9hp8e	177	17	MHV	MHV	NNP
cord-258536-qnn9hp8e	177	18	life	life	NN
cord-258536-qnn9hp8e	177	19	cycle	cycle	NN
cord-258536-qnn9hp8e	177	20	.	.	.
cord-258536-qnn9hp8e	178	1	Importantly	importantly	RB
cord-258536-qnn9hp8e	178	2	,	,	,
cord-258536-qnn9hp8e	178	3	the	the	DT
cord-258536-qnn9hp8e	178	4	genus	genus	NN
cord-258536-qnn9hp8e	178	5	beta	beta	NN
cord-258536-qnn9hp8e	178	6	-	-	HYPH
cord-258536-qnn9hp8e	178	7	CoV	CoV	NNP
cord-258536-qnn9hp8e	178	8	also	also	RB
cord-258536-qnn9hp8e	178	9	includes	include	VBZ
cord-258536-qnn9hp8e	178	10	the	the	DT
cord-258536-qnn9hp8e	178	11	highly	highly	RB
cord-258536-qnn9hp8e	178	12	pathogenic	pathogenic	JJ
cord-258536-qnn9hp8e	178	13	human	human	JJ
cord-258536-qnn9hp8e	178	14	viruses	virus	NNS
cord-258536-qnn9hp8e	178	15	SARS	SARS	NNP
cord-258536-qnn9hp8e	178	16	-	-	HYPH
cord-258536-qnn9hp8e	178	17	CoV	CoV	NNP
cord-258536-qnn9hp8e	178	18	and	and	CC
cord-258536-qnn9hp8e	178	19	MERS	MERS	NNP
cord-258536-qnn9hp8e	178	20	-	-	HYPH
cord-258536-qnn9hp8e	178	21	CoV	CoV	NNP
cord-258536-qnn9hp8e	178	22	,	,	,
cord-258536-qnn9hp8e	178	23	two	two	CD
cord-258536-qnn9hp8e	178	24	viruses	virus	NNS
cord-258536-qnn9hp8e	178	25	that	that	WDT
cord-258536-qnn9hp8e	178	26	cause	cause	VBP
cord-258536-qnn9hp8e	178	27	acute	acute	JJ
cord-258536-qnn9hp8e	178	28	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	178	29	symptoms	symptom	NNS
cord-258536-qnn9hp8e	178	30	and	and	CC
cord-258536-qnn9hp8e	178	31	they	-PRON-	PRP
cord-258536-qnn9hp8e	178	32	are	be	VBP
cord-258536-qnn9hp8e	178	33	on	on	IN
cord-258536-qnn9hp8e	178	34	the	the	DT
cord-258536-qnn9hp8e	178	35	WHO	WHO	NNP
cord-258536-qnn9hp8e	178	36	list	list	NN
cord-258536-qnn9hp8e	178	37	of	of	IN
cord-258536-qnn9hp8e	178	38	viruses	virus	NNS
cord-258536-qnn9hp8e	178	39	likely	likely	JJ
cord-258536-qnn9hp8e	178	40	to	to	TO
cord-258536-qnn9hp8e	178	41	cause	cause	VB
cord-258536-qnn9hp8e	178	42	future	future	JJ
cord-258536-qnn9hp8e	178	43	epidemics	epidemic	NNS
cord-258536-qnn9hp8e	178	44	(	(	-LRB-
cord-258536-qnn9hp8e	178	45	Figure	figure	NN
cord-258536-qnn9hp8e	178	46	1	1	CD
cord-258536-qnn9hp8e	178	47	)	)	-RRB-
cord-258536-qnn9hp8e	178	48	.	.	.
cord-258536-qnn9hp8e	179	1	Like	like	IN
cord-258536-qnn9hp8e	179	2	other	other	JJ
cord-258536-qnn9hp8e	179	3	CoV	cov	NN
cord-258536-qnn9hp8e	179	4	,	,	,
cord-258536-qnn9hp8e	179	5	MHV	MHV	NNP
cord-258536-qnn9hp8e	179	6	replication	replication	NN
cord-258536-qnn9hp8e	179	7	takes	take	VBZ
cord-258536-qnn9hp8e	179	8	place	place	NN
cord-258536-qnn9hp8e	179	9	on	on	IN
cord-258536-qnn9hp8e	179	10	interconnected	interconnect	VBN
cord-258536-qnn9hp8e	179	11	structures	structure	NNS
cord-258536-qnn9hp8e	179	12	formed	form	VBN
cord-258536-qnn9hp8e	179	13	by	by	IN
cord-258536-qnn9hp8e	179	14	convoluted	convoluted	JJ
cord-258536-qnn9hp8e	179	15	membranes	membrane	NNS
cord-258536-qnn9hp8e	179	16	and	and	CC
cord-258536-qnn9hp8e	179	17	DMVs	dmv	NNS
cord-258536-qnn9hp8e	179	18	,	,	,
cord-258536-qnn9hp8e	179	19	with	with	IN
cord-258536-qnn9hp8e	179	20	the	the	DT
cord-258536-qnn9hp8e	179	21	latter	latter	JJ
cord-258536-qnn9hp8e	179	22	being	be	VBG
cord-258536-qnn9hp8e	179	23	reminiscent	reminiscent	JJ
cord-258536-qnn9hp8e	179	24	of	of	IN
cord-258536-qnn9hp8e	179	25	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	179	26	[	[	-LRB-
cord-258536-qnn9hp8e	179	27	80	80	CD
cord-258536-qnn9hp8e	179	28	]	]	-RRB-
cord-258536-qnn9hp8e	179	29	.	.	.
cord-258536-qnn9hp8e	180	1	This	this	DT
cord-258536-qnn9hp8e	180	2	structural	structural	JJ
cord-258536-qnn9hp8e	180	3	similarity	similarity	NN
cord-258536-qnn9hp8e	180	4	prompted	prompt	VBD
cord-258536-qnn9hp8e	180	5	the	the	DT
cord-258536-qnn9hp8e	180	6	investigation	investigation	NN
cord-258536-qnn9hp8e	180	7	of	of	IN
cord-258536-qnn9hp8e	180	8	a	a	DT
cord-258536-qnn9hp8e	180	9	possible	possible	JJ
cord-258536-qnn9hp8e	180	10	interplay	interplay	NN
cord-258536-qnn9hp8e	180	11	between	between	IN
cord-258536-qnn9hp8e	180	12	autophagy	autophagy	NN
cord-258536-qnn9hp8e	180	13	and	and	CC
cord-258536-qnn9hp8e	180	14	CoV	cov	NN
cord-258536-qnn9hp8e	180	15	replication	replication	NN
cord-258536-qnn9hp8e	180	16	.	.	.
cord-258536-qnn9hp8e	181	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	181	2	,	,	,
cord-258536-qnn9hp8e	181	3	the	the	DT
cord-258536-qnn9hp8e	181	4	first	first	JJ
cord-258536-qnn9hp8e	181	5	two	two	CD
cord-258536-qnn9hp8e	181	6	studies	study	NNS
cord-258536-qnn9hp8e	181	7	on	on	IN
cord-258536-qnn9hp8e	181	8	the	the	DT
cord-258536-qnn9hp8e	181	9	importance	importance	NN
cord-258536-qnn9hp8e	181	10	of	of	IN
cord-258536-qnn9hp8e	181	11	ATG	ATG	NNP
cord-258536-qnn9hp8e	181	12	proteins	protein	NNS
cord-258536-qnn9hp8e	181	13	during	during	IN
cord-258536-qnn9hp8e	181	14	MHV	MHV	NNP
cord-258536-qnn9hp8e	181	15	replication	replication	NN
cord-258536-qnn9hp8e	181	16	reached	reach	VBD
cord-258536-qnn9hp8e	181	17	conflicting	conflict	VBG
cord-258536-qnn9hp8e	181	18	conclusions	conclusion	NNS
cord-258536-qnn9hp8e	181	19	.	.	.
cord-258536-qnn9hp8e	182	1	Prentice	Prentice	NNP
cord-258536-qnn9hp8e	182	2	et	et	NNP
cord-258536-qnn9hp8e	182	3	al	al	NNP
cord-258536-qnn9hp8e	182	4	.	.	NNP
cord-258536-qnn9hp8e	182	5	argued	argue	VBD
cord-258536-qnn9hp8e	182	6	that	that	IN
cord-258536-qnn9hp8e	182	7	components	component	NNS
cord-258536-qnn9hp8e	182	8	of	of	IN
cord-258536-qnn9hp8e	182	9	the	the	DT
cord-258536-qnn9hp8e	182	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	182	11	machinery	machinery	NN
cord-258536-qnn9hp8e	182	12	are	be	VBP
cord-258536-qnn9hp8e	182	13	required	require	VBN
cord-258536-qnn9hp8e	182	14	for	for	IN
cord-258536-qnn9hp8e	182	15	MHV	MHV	NNP
cord-258536-qnn9hp8e	182	16	replication	replication	NN
cord-258536-qnn9hp8e	182	17	while	while	IN
cord-258536-qnn9hp8e	182	18	Zhao	Zhao	NNP
cord-258536-qnn9hp8e	182	19	et	et	NNP
cord-258536-qnn9hp8e	182	20	al	al	NNP
cord-258536-qnn9hp8e	182	21	.	.	NNP
cord-258536-qnn9hp8e	182	22	demonstrated	demonstrate	VBD
cord-258536-qnn9hp8e	182	23	that	that	IN
cord-258536-qnn9hp8e	182	24	autophagy	autophagy	NN
cord-258536-qnn9hp8e	182	25	was	be	VBD
cord-258536-qnn9hp8e	182	26	dispensable	dispensable	JJ
cord-258536-qnn9hp8e	182	27	for	for	IN
cord-258536-qnn9hp8e	182	28	the	the	DT
cord-258536-qnn9hp8e	182	29	same	same	JJ
cord-258536-qnn9hp8e	182	30	process	process	NN
cord-258536-qnn9hp8e	182	31	[	[	-LRB-
cord-258536-qnn9hp8e	182	32	65	65	CD
cord-258536-qnn9hp8e	182	33	,	,	,
cord-258536-qnn9hp8e	182	34	66	66	CD
cord-258536-qnn9hp8e	182	35	]	]	-RRB-
cord-258536-qnn9hp8e	182	36	.	.	.
cord-258536-qnn9hp8e	183	1	In	in	IN
cord-258536-qnn9hp8e	183	2	particular	particular	JJ
cord-258536-qnn9hp8e	183	3	,	,	,
cord-258536-qnn9hp8e	183	4	both	both	DT
cord-258536-qnn9hp8e	183	5	teams	team	NNS
cord-258536-qnn9hp8e	183	6	monitored	monitor	VBD
cord-258536-qnn9hp8e	183	7	viral	viral	JJ
cord-258536-qnn9hp8e	183	8	replication	replication	NN
cord-258536-qnn9hp8e	183	9	in	in	IN
cord-258536-qnn9hp8e	183	10	murine	murine	JJ
cord-258536-qnn9hp8e	183	11	embryonic	embryonic	JJ
cord-258536-qnn9hp8e	183	12	fibroblasts	fibroblast	NNS
cord-258536-qnn9hp8e	183	13	(	(	-LRB-
cord-258536-qnn9hp8e	183	14	MEFs	MEFs	NNP
cord-258536-qnn9hp8e	183	15	)	)	-RRB-
cord-258536-qnn9hp8e	183	16	knocked	knock	VBD
cord-258536-qnn9hp8e	183	17	out	out	RP
cord-258536-qnn9hp8e	183	18	for	for	IN
cord-258536-qnn9hp8e	183	19	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	183	20	.	.	.
cord-258536-qnn9hp8e	184	1	The	the	DT
cord-258536-qnn9hp8e	184	2	first	first	JJ
cord-258536-qnn9hp8e	184	3	group	group	NN
cord-258536-qnn9hp8e	184	4	found	find	VBD
cord-258536-qnn9hp8e	184	5	that	that	IN
cord-258536-qnn9hp8e	184	6	both	both	CC
cord-258536-qnn9hp8e	184	7	MHV	MHV	NNP
cord-258536-qnn9hp8e	184	8	replication	replication	NN
cord-258536-qnn9hp8e	184	9	and	and	CC
cord-258536-qnn9hp8e	184	10	DMV	DMV	NNP
cord-258536-qnn9hp8e	184	11	formation	formation	NN
cord-258536-qnn9hp8e	184	12	was	be	VBD
cord-258536-qnn9hp8e	184	13	impaired	impair	VBN
cord-258536-qnn9hp8e	184	14	in	in	IN
cord-258536-qnn9hp8e	184	15	atg5	atg5	JJ
cord-258536-qnn9hp8e	184	16	−/−	−/−	NNP
cord-258536-qnn9hp8e	184	17	knockout	knockout	NN
cord-258536-qnn9hp8e	184	18	cells	cell	NNS
cord-258536-qnn9hp8e	184	19	,	,	,
cord-258536-qnn9hp8e	184	20	while	while	IN
cord-258536-qnn9hp8e	184	21	the	the	DT
cord-258536-qnn9hp8e	184	22	second	second	JJ
cord-258536-qnn9hp8e	184	23	did	do	VBD
cord-258536-qnn9hp8e	184	24	not	not	RB
cord-258536-qnn9hp8e	184	25	observe	observe	VB
cord-258536-qnn9hp8e	184	26	any	any	DT
cord-258536-qnn9hp8e	184	27	effect	effect	NN
cord-258536-qnn9hp8e	184	28	on	on	IN
cord-258536-qnn9hp8e	184	29	MHV	MHV	NNP
cord-258536-qnn9hp8e	184	30	life	life	NN
cord-258536-qnn9hp8e	184	31	cycle	cycle	NN
cord-258536-qnn9hp8e	184	32	in	in	IN
cord-258536-qnn9hp8e	184	33	absence	absence	NN
cord-258536-qnn9hp8e	184	34	of	of	IN
cord-258536-qnn9hp8e	184	35	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	184	36	[	[	-LRB-
cord-258536-qnn9hp8e	184	37	65	65	CD
cord-258536-qnn9hp8e	184	38	,	,	,
cord-258536-qnn9hp8e	184	39	66	66	CD
cord-258536-qnn9hp8e	184	40	]	]	-RRB-
cord-258536-qnn9hp8e	184	41	.	.	.
cord-258536-qnn9hp8e	185	1	The	the	DT
cord-258536-qnn9hp8e	185	2	fact	fact	NN
cord-258536-qnn9hp8e	185	3	that	that	IN
cord-258536-qnn9hp8e	185	4	MHV	MHV	NNP
cord-258536-qnn9hp8e	185	5	infection	infection	NN
cord-258536-qnn9hp8e	185	6	does	do	VBZ
cord-258536-qnn9hp8e	185	7	not	not	RB
cord-258536-qnn9hp8e	185	8	require	require	VB
cord-258536-qnn9hp8e	185	9	intact	intact	JJ
cord-258536-qnn9hp8e	185	10	ATG	ATG	NNP
cord-258536-qnn9hp8e	185	11	machinery	machinery	NN
cord-258536-qnn9hp8e	185	12	was	be	VBD
cord-258536-qnn9hp8e	185	13	also	also	RB
cord-258536-qnn9hp8e	185	14	later	later	RB
cord-258536-qnn9hp8e	185	15	confirmed	confirm	VBN
cord-258536-qnn9hp8e	185	16	by	by	IN
cord-258536-qnn9hp8e	185	17	another	another	DT
cord-258536-qnn9hp8e	185	18	group	group	NN
cord-258536-qnn9hp8e	185	19	using	use	VBG
cord-258536-qnn9hp8e	185	20	atg7	atg7	NNP
cord-258536-qnn9hp8e	185	21	−/−	−/−	NNP
cord-258536-qnn9hp8e	185	22	MEFs	MEFs	NNP
cord-258536-qnn9hp8e	185	23	[	[	-LRB-
cord-258536-qnn9hp8e	185	24	67	67	CD
cord-258536-qnn9hp8e	185	25	]	]	-RRB-
cord-258536-qnn9hp8e	185	26	.	.	.
cord-258536-qnn9hp8e	186	1	Data	datum	NNS
cord-258536-qnn9hp8e	186	2	from	from	IN
cord-258536-qnn9hp8e	186	3	both	both	DT
cord-258536-qnn9hp8e	186	4	laboratories	laboratory	NNS
cord-258536-qnn9hp8e	186	5	,	,	,
cord-258536-qnn9hp8e	186	6	however	however	RB
cord-258536-qnn9hp8e	186	7	,	,	,
cord-258536-qnn9hp8e	186	8	established	establish	VBD
cord-258536-qnn9hp8e	186	9	that	that	IN
cord-258536-qnn9hp8e	186	10	the	the	DT
cord-258536-qnn9hp8e	186	11	viral	viral	JJ
cord-258536-qnn9hp8e	186	12	RTCs	rtc	NNS
cord-258536-qnn9hp8e	186	13	are	be	VBP
cord-258536-qnn9hp8e	186	14	co	co	NN
cord-258536-qnn9hp8e	186	15	-	-	JJ
cord-258536-qnn9hp8e	186	16	localizing	localize	VBG
cord-258536-qnn9hp8e	186	17	with	with	IN
cord-258536-qnn9hp8e	186	18	endogenous	endogenous	JJ
cord-258536-qnn9hp8e	186	19	LC3	lc3	NN
cord-258536-qnn9hp8e	186	20	,	,	,
cord-258536-qnn9hp8e	186	21	which	which	WDT
cord-258536-qnn9hp8e	186	22	on	on	IN
cord-258536-qnn9hp8e	186	23	one	one	CD
cord-258536-qnn9hp8e	186	24	hand	hand	NN
cord-258536-qnn9hp8e	186	25	was	be	VBD
cord-258536-qnn9hp8e	186	26	in	in	IN
cord-258536-qnn9hp8e	186	27	agreement	agreement	NN
cord-258536-qnn9hp8e	186	28	with	with	IN
cord-258536-qnn9hp8e	186	29	observations	observation	NNS
cord-258536-qnn9hp8e	186	30	gained	gain	VBN
cord-258536-qnn9hp8e	186	31	from	from	IN
cord-258536-qnn9hp8e	186	32	SARS	SARS	NNP
cord-258536-qnn9hp8e	186	33	-	-	HYPH
cord-258536-qnn9hp8e	186	34	CoV	CoV	NNP
cord-258536-qnn9hp8e	186	35	,	,	,
cord-258536-qnn9hp8e	186	36	but	but	CC
cord-258536-qnn9hp8e	186	37	on	on	IN
cord-258536-qnn9hp8e	186	38	the	the	DT
cord-258536-qnn9hp8e	186	39	other	other	JJ
cord-258536-qnn9hp8e	186	40	hand	hand	NN
cord-258536-qnn9hp8e	186	41	was	be	VBD
cord-258536-qnn9hp8e	186	42	conflicting	conflict	VBG
cord-258536-qnn9hp8e	186	43	with	with	IN
cord-258536-qnn9hp8e	186	44	results	result	NNS
cord-258536-qnn9hp8e	186	45	obtained	obtain	VBN
cord-258536-qnn9hp8e	186	46	with	with	IN
cord-258536-qnn9hp8e	186	47	MHV	MHV	NNP
cord-258536-qnn9hp8e	186	48	by	by	IN
cord-258536-qnn9hp8e	186	49	a	a	DT
cord-258536-qnn9hp8e	186	50	third	third	JJ
cord-258536-qnn9hp8e	186	51	group	group	NN
cord-258536-qnn9hp8e	186	52	[	[	-LRB-
cord-258536-qnn9hp8e	186	53	81	81	CD
cord-258536-qnn9hp8e	186	54	,	,	,
cord-258536-qnn9hp8e	186	55	82	82	CD
cord-258536-qnn9hp8e	186	56	]	]	-RRB-
cord-258536-qnn9hp8e	186	57	.	.	.
cord-258536-qnn9hp8e	187	1	These	these	DT
cord-258536-qnn9hp8e	187	2	apparent	apparent	JJ
cord-258536-qnn9hp8e	187	3	discrepancies	discrepancy	NNS
cord-258536-qnn9hp8e	187	4	were	be	VBD
cord-258536-qnn9hp8e	187	5	subsequently	subsequently	RB
cord-258536-qnn9hp8e	187	6	explained	explain	VBN
cord-258536-qnn9hp8e	187	7	by	by	IN
cord-258536-qnn9hp8e	187	8	showing	show	VBG
cord-258536-qnn9hp8e	187	9	that	that	IN
cord-258536-qnn9hp8e	187	10	endogenous	endogenous	JJ
cord-258536-qnn9hp8e	187	11	LC3	lc3	NN
cord-258536-qnn9hp8e	187	12	but	but	CC
cord-258536-qnn9hp8e	187	13	not	not	RB
cord-258536-qnn9hp8e	187	14	ectopically	ectopically	RB
cord-258536-qnn9hp8e	187	15	expressed	express	VBD
cord-258536-qnn9hp8e	187	16	GFP	GFP	NNP
cord-258536-qnn9hp8e	187	17	-	-	HYPH
cord-258536-qnn9hp8e	187	18	LC3	lc3	NN
cord-258536-qnn9hp8e	187	19	co	co	NN
cord-258536-qnn9hp8e	187	20	-	-	NN
cord-258536-qnn9hp8e	187	21	localizes	localize	VBZ
cord-258536-qnn9hp8e	187	22	with	with	IN
cord-258536-qnn9hp8e	187	23	CoV	CoV	NNP
cord-258536-qnn9hp8e	187	24	RTCs	RTCs	NNP
cord-258536-qnn9hp8e	187	25	[	[	-LRB-
cord-258536-qnn9hp8e	187	26	67	67	CD
cord-258536-qnn9hp8e	187	27	]	]	-RRB-
cord-258536-qnn9hp8e	187	28	.	.	.
cord-258536-qnn9hp8e	188	1	Data	datum	NNS
cord-258536-qnn9hp8e	188	2	from	from	IN
cord-258536-qnn9hp8e	188	3	different	different	JJ
cord-258536-qnn9hp8e	188	4	groups	group	NNS
cord-258536-qnn9hp8e	188	5	strongly	strongly	RB
cord-258536-qnn9hp8e	188	6	support	support	VBP
cord-258536-qnn9hp8e	188	7	an	an	DT
cord-258536-qnn9hp8e	188	8	ER	ER	NNP
cord-258536-qnn9hp8e	188	9	involvement	involvement	NN
cord-258536-qnn9hp8e	188	10	in	in	IN
cord-258536-qnn9hp8e	188	11	convoluted	convoluted	JJ
cord-258536-qnn9hp8e	188	12	membranes	membrane	NNS
cord-258536-qnn9hp8e	188	13	and	and	CC
cord-258536-qnn9hp8e	188	14	DMVs	dmv	NNS
cord-258536-qnn9hp8e	188	15	biogenesis	biogenesis	NN
cord-258536-qnn9hp8e	188	16	,	,	,
cord-258536-qnn9hp8e	188	17	as	as	IN
cord-258536-qnn9hp8e	188	18	those	those	DT
cord-258536-qnn9hp8e	188	19	structures	structure	NNS
cord-258536-qnn9hp8e	188	20	can	can	MD
cord-258536-qnn9hp8e	188	21	be	be	VB
cord-258536-qnn9hp8e	188	22	found	find	VBN
cord-258536-qnn9hp8e	188	23	connected	connect	VBN
cord-258536-qnn9hp8e	188	24	to	to	IN
cord-258536-qnn9hp8e	188	25	the	the	DT
cord-258536-qnn9hp8e	188	26	ER	ER	NNP
cord-258536-qnn9hp8e	188	27	and	and	CC
cord-258536-qnn9hp8e	188	28	transmembrane	transmembrane	NN
cord-258536-qnn9hp8e	188	29	nsp	nsp	NN
cord-258536-qnn9hp8e	188	30	proteins	protein	NNS
cord-258536-qnn9hp8e	188	31	can	can	MD
cord-258536-qnn9hp8e	188	32	be	be	VB
cord-258536-qnn9hp8e	188	33	glycosylated	glycosylate	VBN
cord-258536-qnn9hp8e	188	34	and	and	CC
cord-258536-qnn9hp8e	188	35	localize	localize	VB
cord-258536-qnn9hp8e	188	36	to	to	IN
cord-258536-qnn9hp8e	188	37	the	the	DT
cord-258536-qnn9hp8e	188	38	ER	er	NN
cord-258536-qnn9hp8e	188	39	when	when	WRB
cord-258536-qnn9hp8e	188	40	individually	individually	RB
cord-258536-qnn9hp8e	188	41	expressed	express	VBD
cord-258536-qnn9hp8e	188	42	[	[	-LRB-
cord-258536-qnn9hp8e	188	43	83	83	CD
cord-258536-qnn9hp8e	188	44	,	,	,
cord-258536-qnn9hp8e	188	45	84	84	CD
cord-258536-qnn9hp8e	188	46	]	]	-RRB-
cord-258536-qnn9hp8e	188	47	.	.	.
cord-258536-qnn9hp8e	189	1	The	the	DT
cord-258536-qnn9hp8e	189	2	RTCs	rtc	NNS
cord-258536-qnn9hp8e	189	3	and	and	CC
cord-258536-qnn9hp8e	189	4	DMVs	dmv	NNS
cord-258536-qnn9hp8e	189	5	,	,	,
cord-258536-qnn9hp8e	189	6	however	however	RB
cord-258536-qnn9hp8e	189	7	,	,	,
cord-258536-qnn9hp8e	189	8	do	do	VBP
cord-258536-qnn9hp8e	189	9	not	not	RB
cord-258536-qnn9hp8e	189	10	co	co	VB
cord-258536-qnn9hp8e	189	11	-	-	VB
cord-258536-qnn9hp8e	189	12	localize	localize	VB
cord-258536-qnn9hp8e	189	13	with	with	IN
cord-258536-qnn9hp8e	189	14	marker	marker	NN
cord-258536-qnn9hp8e	189	15	proteins	protein	NNS
cord-258536-qnn9hp8e	189	16	of	of	IN
cord-258536-qnn9hp8e	189	17	the	the	DT
cord-258536-qnn9hp8e	189	18	ER	ER	NNP
cord-258536-qnn9hp8e	189	19	,	,	,
cord-258536-qnn9hp8e	189	20	ERGIC	ERGIC	NNP
cord-258536-qnn9hp8e	189	21	,	,	,
cord-258536-qnn9hp8e	189	22	and	and	CC
cord-258536-qnn9hp8e	189	23	the	the	DT
cord-258536-qnn9hp8e	189	24	Golgi	Golgi	NNP
cord-258536-qnn9hp8e	189	25	[	[	-LRB-
cord-258536-qnn9hp8e	189	26	82	82	CD
cord-258536-qnn9hp8e	189	27	,	,	,
cord-258536-qnn9hp8e	189	28	84	84	CD
cord-258536-qnn9hp8e	189	29	]	]	-RRB-
cord-258536-qnn9hp8e	189	30	and	and	CC
cord-258536-qnn9hp8e	189	31	disruption	disruption	NN
cord-258536-qnn9hp8e	189	32	of	of	IN
cord-258536-qnn9hp8e	189	33	the	the	DT
cord-258536-qnn9hp8e	189	34	secretory	secretory	JJ
cord-258536-qnn9hp8e	189	35	pathway	pathway	NN
cord-258536-qnn9hp8e	189	36	has	have	VBZ
cord-258536-qnn9hp8e	189	37	no	no	DT
cord-258536-qnn9hp8e	189	38	major	major	JJ
cord-258536-qnn9hp8e	189	39	effect	effect	NN
cord-258536-qnn9hp8e	189	40	on	on	IN
cord-258536-qnn9hp8e	189	41	CoV	cov	NN
cord-258536-qnn9hp8e	189	42	replication	replication	NN
cord-258536-qnn9hp8e	189	43	[	[	-LRB-
cord-258536-qnn9hp8e	189	44	85	85	CD
cord-258536-qnn9hp8e	189	45	]	]	-RRB-
cord-258536-qnn9hp8e	189	46	.	.	.
cord-258536-qnn9hp8e	190	1	This	this	DT
cord-258536-qnn9hp8e	190	2	indicates	indicate	VBZ
cord-258536-qnn9hp8e	190	3	that	that	IN
cord-258536-qnn9hp8e	190	4	DMVs	dmv	NNS
cord-258536-qnn9hp8e	190	5	'	'	POS
cord-258536-qnn9hp8e	190	6	biogenesis	biogenesis	NN
cord-258536-qnn9hp8e	190	7	might	may	MD
cord-258536-qnn9hp8e	190	8	not	not	RB
cord-258536-qnn9hp8e	190	9	involve	involve	VB
cord-258536-qnn9hp8e	190	10	the	the	DT
cord-258536-qnn9hp8e	190	11	secretory	secretory	JJ
cord-258536-qnn9hp8e	190	12	pathway	pathway	NN
cord-258536-qnn9hp8e	190	13	.	.	.
cord-258536-qnn9hp8e	191	1	In	in	IN
cord-258536-qnn9hp8e	191	2	contrast	contrast	NN
cord-258536-qnn9hp8e	191	3	,	,	,
cord-258536-qnn9hp8e	191	4	the	the	DT
cord-258536-qnn9hp8e	191	5	ER	ER	NNP
cord-258536-qnn9hp8e	191	6	-	-	HYPH
cord-258536-qnn9hp8e	191	7	associated	associate	VBN
cord-258536-qnn9hp8e	191	8	degradation	degradation	NN
cord-258536-qnn9hp8e	191	9	(	(	-LRB-
cord-258536-qnn9hp8e	191	10	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	191	11	)	)	-RRB-
cord-258536-qnn9hp8e	191	12	tuning	tuning	NN
cord-258536-qnn9hp8e	191	13	pathway	pathway	NN
cord-258536-qnn9hp8e	191	14	,	,	,
cord-258536-qnn9hp8e	191	15	a	a	DT
cord-258536-qnn9hp8e	191	16	vesicular	vesicular	JJ
cord-258536-qnn9hp8e	191	17	transport	transport	NN
cord-258536-qnn9hp8e	191	18	route	route	NN
cord-258536-qnn9hp8e	191	19	out	out	IN
cord-258536-qnn9hp8e	191	20	of	of	IN
cord-258536-qnn9hp8e	191	21	the	the	DT
cord-258536-qnn9hp8e	191	22	ER	ER	NNP
cord-258536-qnn9hp8e	191	23	,	,	,
cord-258536-qnn9hp8e	191	24	has	have	VBZ
cord-258536-qnn9hp8e	191	25	been	be	VBN
cord-258536-qnn9hp8e	191	26	shown	show	VBN
cord-258536-qnn9hp8e	191	27	to	to	TO
cord-258536-qnn9hp8e	191	28	be	be	VB
cord-258536-qnn9hp8e	191	29	important	important	JJ
cord-258536-qnn9hp8e	191	30	for	for	IN
cord-258536-qnn9hp8e	191	31	CoV	cov	NN
cord-258536-qnn9hp8e	191	32	infection	infection	NN
cord-258536-qnn9hp8e	191	33	[	[	-LRB-
cord-258536-qnn9hp8e	191	34	86	86	CD
cord-258536-qnn9hp8e	191	35	]	]	-RRB-
cord-258536-qnn9hp8e	191	36	.	.	.
cord-258536-qnn9hp8e	192	1	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	192	2	allows	allow	VBZ
cord-258536-qnn9hp8e	192	3	for	for	IN
cord-258536-qnn9hp8e	192	4	the	the	DT
cord-258536-qnn9hp8e	192	5	degradation	degradation	NN
cord-258536-qnn9hp8e	192	6	of	of	IN
cord-258536-qnn9hp8e	192	7	misfolded	misfolde	VBN
cord-258536-qnn9hp8e	192	8	ER	ER	NNP
cord-258536-qnn9hp8e	192	9	proteins	protein	NNS
cord-258536-qnn9hp8e	192	10	and	and	CC
cord-258536-qnn9hp8e	192	11	it	-PRON-	PRP
cord-258536-qnn9hp8e	192	12	is	be	VBZ
cord-258536-qnn9hp8e	192	13	negatively	negatively	RB
cord-258536-qnn9hp8e	192	14	regulated	regulate	VBN
cord-258536-qnn9hp8e	192	15	during	during	IN
cord-258536-qnn9hp8e	192	16	normal	normal	JJ
cord-258536-qnn9hp8e	192	17	growing	grow	VBG
cord-258536-qnn9hp8e	192	18	conditions	condition	NNS
cord-258536-qnn9hp8e	192	19	,	,	,
cord-258536-qnn9hp8e	192	20	in	in	IN
cord-258536-qnn9hp8e	192	21	absence	absence	NN
cord-258536-qnn9hp8e	192	22	of	of	IN
cord-258536-qnn9hp8e	192	23	stress	stress	NN
cord-258536-qnn9hp8e	192	24	.	.	.
cord-258536-qnn9hp8e	193	1	This	this	DT
cord-258536-qnn9hp8e	193	2	tuning	tuning	NN
cord-258536-qnn9hp8e	193	3	down	down	RP
cord-258536-qnn9hp8e	193	4	of	of	IN
cord-258536-qnn9hp8e	193	5	the	the	DT
cord-258536-qnn9hp8e	193	6	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	193	7	activity	activity	NN
cord-258536-qnn9hp8e	193	8	is	be	VBZ
cord-258536-qnn9hp8e	193	9	mediated	mediate	VBN
cord-258536-qnn9hp8e	193	10	at	at	IN
cord-258536-qnn9hp8e	193	11	least	least	JJS
cord-258536-qnn9hp8e	193	12	in	in	IN
cord-258536-qnn9hp8e	193	13	part	part	NN
cord-258536-qnn9hp8e	193	14	by	by	IN
cord-258536-qnn9hp8e	193	15	small	small	JJ
cord-258536-qnn9hp8e	193	16	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	193	17	called	call	VBN
cord-258536-qnn9hp8e	193	18	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	193	19	,	,	,
cord-258536-qnn9hp8e	193	20	which	which	WDT
cord-258536-qnn9hp8e	193	21	specifically	specifically	RB
cord-258536-qnn9hp8e	193	22	capture	capture	VBP
cord-258536-qnn9hp8e	193	23	key	key	JJ
cord-258536-qnn9hp8e	193	24	positive	positive	JJ
cord-258536-qnn9hp8e	193	25	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	193	26	regulators	regulator	NNS
cord-258536-qnn9hp8e	193	27	such	such	JJ
cord-258536-qnn9hp8e	193	28	as	as	IN
cord-258536-qnn9hp8e	193	29	EDEM1	EDEM1	NNS
cord-258536-qnn9hp8e	193	30	and	and	CC
cord-258536-qnn9hp8e	193	31	OS-9	OS-9	NNP
cord-258536-qnn9hp8e	193	32	,	,	,
cord-258536-qnn9hp8e	193	33	and	and	CC
cord-258536-qnn9hp8e	193	34	degrade	degrade	VB
cord-258536-qnn9hp8e	193	35	them	-PRON-	PRP
cord-258536-qnn9hp8e	193	36	in	in	IN
cord-258536-qnn9hp8e	193	37	compartments	compartment	NNS
cord-258536-qnn9hp8e	193	38	of	of	IN
cord-258536-qnn9hp8e	193	39	the	the	DT
cord-258536-qnn9hp8e	193	40	endolysosomal	endolysosomal	JJ
cord-258536-qnn9hp8e	193	41	system	system	NN
cord-258536-qnn9hp8e	193	42	[	[	-LRB-
cord-258536-qnn9hp8e	193	43	56	56	CD
cord-258536-qnn9hp8e	193	44	]	]	-RRB-
cord-258536-qnn9hp8e	193	45	.	.	.
cord-258536-qnn9hp8e	194	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	194	2	,	,	,
cord-258536-qnn9hp8e	194	3	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	194	4	are	be	VBP
cord-258536-qnn9hp8e	194	5	decorated	decorate	VBN
cord-258536-qnn9hp8e	194	6	with	with	IN
cord-258536-qnn9hp8e	194	7	non	non	JJ
cord-258536-qnn9hp8e	194	8	-	-	JJ
cord-258536-qnn9hp8e	194	9	lipidated	lipidated	JJ
cord-258536-qnn9hp8e	194	10	from	from	IN
cord-258536-qnn9hp8e	194	11	of	of	IN
cord-258536-qnn9hp8e	194	12	LC3	LC3	NNP
cord-258536-qnn9hp8e	194	13	(	(	-LRB-
cord-258536-qnn9hp8e	194	14	also	also	RB
cord-258536-qnn9hp8e	194	15	called	call	VBN
cord-258536-qnn9hp8e	194	16	LC3-I	LC3-I	NNP
cord-258536-qnn9hp8e	194	17	)	)	-RRB-
cord-258536-qnn9hp8e	194	18	and	and	CC
cord-258536-qnn9hp8e	194	19	their	-PRON-	PRP$
cord-258536-qnn9hp8e	194	20	formation	formation	NN
cord-258536-qnn9hp8e	194	21	might	may	MD
cord-258536-qnn9hp8e	194	22	require	require	VB
cord-258536-qnn9hp8e	194	23	selected	select	VBN
cord-258536-qnn9hp8e	194	24	components	component	NNS
cord-258536-qnn9hp8e	194	25	of	of	IN
cord-258536-qnn9hp8e	194	26	the	the	DT
cord-258536-qnn9hp8e	194	27	ATG	ATG	NNP
cord-258536-qnn9hp8e	194	28	machinery	machinery	NN
cord-258536-qnn9hp8e	194	29	,	,	,
cord-258536-qnn9hp8e	194	30	such	such	JJ
cord-258536-qnn9hp8e	194	31	as	as	IN
cord-258536-qnn9hp8e	194	32	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	194	33	[	[	-LRB-
cord-258536-qnn9hp8e	194	34	54	54	CD
cord-258536-qnn9hp8e	194	35	,	,	,
cord-258536-qnn9hp8e	194	36	55	55	CD
cord-258536-qnn9hp8e	194	37	]	]	-RRB-
cord-258536-qnn9hp8e	194	38	.	.	.
cord-258536-qnn9hp8e	195	1	Reggiori	Reggiori	NNP
cord-258536-qnn9hp8e	195	2	et	et	NNP
cord-258536-qnn9hp8e	195	3	al	al	NNP
cord-258536-qnn9hp8e	195	4	.	.	.
cord-258536-qnn9hp8e	196	1	eventually	eventually	RB
cord-258536-qnn9hp8e	196	2	revealed	reveal	VBD
cord-258536-qnn9hp8e	196	3	that	that	IN
cord-258536-qnn9hp8e	196	4	DMVs	dmv	NNS
cord-258536-qnn9hp8e	196	5	were	be	VBD
cord-258536-qnn9hp8e	196	6	associated	associate	VBN
cord-258536-qnn9hp8e	196	7	with	with	IN
cord-258536-qnn9hp8e	196	8	LC3-I	LC3-I	NNP
cord-258536-qnn9hp8e	196	9	and	and	CC
cord-258536-qnn9hp8e	196	10	positive	positive	JJ
cord-258536-qnn9hp8e	196	11	for	for	IN
cord-258536-qnn9hp8e	197	1	both	both	DT
cord-258536-qnn9hp8e	197	2	EDEM1	EDEM1	NNS
cord-258536-qnn9hp8e	197	3	and	and	CC
cord-258536-qnn9hp8e	197	4	OS-9	OS-9	NNP
cord-258536-qnn9hp8e	197	5	,	,	,
cord-258536-qnn9hp8e	197	6	suggesting	suggest	VBG
cord-258536-qnn9hp8e	197	7	that	that	IN
cord-258536-qnn9hp8e	197	8	MHV	MHV	NNP
cord-258536-qnn9hp8e	197	9	might	may	MD
cord-258536-qnn9hp8e	197	10	actually	actually	RB
cord-258536-qnn9hp8e	197	11	highjack	highjack	VB
cord-258536-qnn9hp8e	197	12	part	part	NN
cord-258536-qnn9hp8e	197	13	of	of	IN
cord-258536-qnn9hp8e	197	14	the	the	DT
cord-258536-qnn9hp8e	197	15	membranes	membrane	NNS
cord-258536-qnn9hp8e	197	16	of	of	IN
cord-258536-qnn9hp8e	197	17	the	the	DT
cord-258536-qnn9hp8e	197	18	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	197	19	tuning	tuning	NN
cord-258536-qnn9hp8e	197	20	pathway	pathway	NN
cord-258536-qnn9hp8e	197	21	[	[	-LRB-
cord-258536-qnn9hp8e	197	22	67	67	CD
cord-258536-qnn9hp8e	197	23	]	]	-RRB-
cord-258536-qnn9hp8e	197	24	.	.	.
cord-258536-qnn9hp8e	198	1	Although	although	IN
cord-258536-qnn9hp8e	198	2	expression	expression	NN
cord-258536-qnn9hp8e	198	3	of	of	IN
cord-258536-qnn9hp8e	198	4	a	a	DT
cord-258536-qnn9hp8e	198	5	non	non	JJ
cord-258536-qnn9hp8e	198	6	-	-	JJ
cord-258536-qnn9hp8e	198	7	lipidable	lipidable	JJ
cord-258536-qnn9hp8e	198	8	LC3	lc3	NN
cord-258536-qnn9hp8e	198	9	impaired	impair	VBN
cord-258536-qnn9hp8e	198	10	DMVs	dmv	NNS
cord-258536-qnn9hp8e	198	11	biogenesis	biogenesis	NN
cord-258536-qnn9hp8e	198	12	and	and	CC
cord-258536-qnn9hp8e	198	13	viral	viral	JJ
cord-258536-qnn9hp8e	198	14	replication	replication	NN
cord-258536-qnn9hp8e	198	15	,	,	,
cord-258536-qnn9hp8e	198	16	absence	absence	NN
cord-258536-qnn9hp8e	198	17	of	of	IN
cord-258536-qnn9hp8e	198	18	EDEM1	edem1	NN
cord-258536-qnn9hp8e	198	19	and	and	CC
cord-258536-qnn9hp8e	198	20	OS-9	OS-9	NNP
cord-258536-qnn9hp8e	198	21	had	have	VBD
cord-258536-qnn9hp8e	198	22	no	no	DT
cord-258536-qnn9hp8e	198	23	effect	effect	NN
cord-258536-qnn9hp8e	198	24	.	.	.
cord-258536-qnn9hp8e	199	1	Thus	thus	RB
cord-258536-qnn9hp8e	199	2	,	,	,
cord-258536-qnn9hp8e	199	3	the	the	DT
cord-258536-qnn9hp8e	199	4	authors	author	NNS
cord-258536-qnn9hp8e	199	5	hypothesized	hypothesize	VBD
cord-258536-qnn9hp8e	199	6	that	that	IN
cord-258536-qnn9hp8e	199	7	one	one	CD
cord-258536-qnn9hp8e	199	8	or	or	CC
cord-258536-qnn9hp8e	199	9	more	more	JJR
cord-258536-qnn9hp8e	199	10	nsp	nsp	NN
cord-258536-qnn9hp8e	199	11	proteins	protein	NNS
cord-258536-qnn9hp8e	199	12	might	may	MD
cord-258536-qnn9hp8e	199	13	associate	associate	VB
cord-258536-qnn9hp8e	199	14	with	with	IN
cord-258536-qnn9hp8e	199	15	components	component	NNS
cord-258536-qnn9hp8e	199	16	of	of	IN
cord-258536-qnn9hp8e	199	17	the	the	DT
cord-258536-qnn9hp8e	199	18	machinery	machinery	NN
cord-258536-qnn9hp8e	199	19	of	of	IN
cord-258536-qnn9hp8e	199	20	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	199	21	,	,	,
cord-258536-qnn9hp8e	199	22	such	such	JJ
cord-258536-qnn9hp8e	199	23	as	as	IN
cord-258536-qnn9hp8e	199	24	a	a	DT
cord-258536-qnn9hp8e	199	25	cargo	cargo	NN
cord-258536-qnn9hp8e	199	26	receptor	receptor	NN
cord-258536-qnn9hp8e	199	27	or	or	CC
cord-258536-qnn9hp8e	199	28	a	a	DT
cord-258536-qnn9hp8e	199	29	coat	coat	NN
cord-258536-qnn9hp8e	199	30	protein	protein	NN
cord-258536-qnn9hp8e	199	31	,	,	,
cord-258536-qnn9hp8e	199	32	to	to	TO
cord-258536-qnn9hp8e	199	33	subvert	subvert	VB
cord-258536-qnn9hp8e	199	34	these	these	DT
cord-258536-qnn9hp8e	199	35	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	199	36	and	and	CC
cord-258536-qnn9hp8e	199	37	generate	generate	VB
cord-258536-qnn9hp8e	199	38	the	the	DT
cord-258536-qnn9hp8e	199	39	DMVs	dmv	NNS
cord-258536-qnn9hp8e	199	40	.	.	.
cord-258536-qnn9hp8e	200	1	LC3-I	LC3-I	NNP
cord-258536-qnn9hp8e	200	2	could	could	MD
cord-258536-qnn9hp8e	200	3	be	be	VB
cord-258536-qnn9hp8e	200	4	such	such	PDT
cord-258536-qnn9hp8e	200	5	a	a	DT
cord-258536-qnn9hp8e	200	6	candidate	candidate	NN
cord-258536-qnn9hp8e	200	7	but	but	CC
cord-258536-qnn9hp8e	200	8	no	no	DT
cord-258536-qnn9hp8e	200	9	interaction	interaction	NN
cord-258536-qnn9hp8e	200	10	between	between	IN
cord-258536-qnn9hp8e	200	11	LC3-I	LC3-I	NNP
cord-258536-qnn9hp8e	200	12	and	and	CC
cord-258536-qnn9hp8e	200	13	MHV	MHV	NNP
cord-258536-qnn9hp8e	200	14	nsp	nsp	NN
cord-258536-qnn9hp8e	200	15	proteins	protein	NNS
cord-258536-qnn9hp8e	200	16	was	be	VBD
cord-258536-qnn9hp8e	200	17	detected	detect	VBN
cord-258536-qnn9hp8e	200	18	using	use	VBG
cord-258536-qnn9hp8e	200	19	the	the	DT
cord-258536-qnn9hp8e	200	20	yeast	yeast	NN
cord-258536-qnn9hp8e	200	21	two	two	CD
cord-258536-qnn9hp8e	200	22	-	-	HYPH
cord-258536-qnn9hp8e	200	23	hybrid	hybrid	NN
cord-258536-qnn9hp8e	200	24	assay	assay	NN
cord-258536-qnn9hp8e	200	25	[	[	-LRB-
cord-258536-qnn9hp8e	200	26	67	67	CD
cord-258536-qnn9hp8e	200	27	]	]	-RRB-
cord-258536-qnn9hp8e	200	28	.	.	.
cord-258536-qnn9hp8e	201	1	How	how	WRB
cord-258536-qnn9hp8e	201	2	MHV	MHV	NNP
cord-258536-qnn9hp8e	201	3	highjacks	highjack	VBZ
cord-258536-qnn9hp8e	201	4	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	201	5	and	and	CC
cord-258536-qnn9hp8e	201	6	what	what	WP
cord-258536-qnn9hp8e	201	7	the	the	DT
cord-258536-qnn9hp8e	201	8	exact	exact	JJ
cord-258536-qnn9hp8e	201	9	role	role	NN
cord-258536-qnn9hp8e	201	10	of	of	IN
cord-258536-qnn9hp8e	201	11	LC3-I	LC3-I	NNP
cord-258536-qnn9hp8e	201	12	is	be	VBZ
cord-258536-qnn9hp8e	201	13	in	in	IN
cord-258536-qnn9hp8e	201	14	this	this	DT
cord-258536-qnn9hp8e	201	15	process	process	NN
cord-258536-qnn9hp8e	201	16	are	be	VBP
cord-258536-qnn9hp8e	201	17	questions	question	NNS
cord-258536-qnn9hp8e	201	18	that	that	WDT
cord-258536-qnn9hp8e	201	19	remain	remain	VBP
cord-258536-qnn9hp8e	201	20	unanswered	unanswered	JJ
cord-258536-qnn9hp8e	201	21	.	.	.
cord-258536-qnn9hp8e	202	1	Overall	overall	RB
cord-258536-qnn9hp8e	202	2	,	,	,
cord-258536-qnn9hp8e	202	3	beta	beta	NN
cord-258536-qnn9hp8e	202	4	-	-	HYPH
cord-258536-qnn9hp8e	202	5	CoV	cov	NN
cord-258536-qnn9hp8e	202	6	interactions	interaction	NNS
cord-258536-qnn9hp8e	202	7	with	with	IN
cord-258536-qnn9hp8e	202	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	202	9	and	and	CC
cord-258536-qnn9hp8e	202	10	ATG	ATG	NNP
cord-258536-qnn9hp8e	202	11	proteins	protein	NNS
cord-258536-qnn9hp8e	202	12	appear	appear	VBP
cord-258536-qnn9hp8e	202	13	to	to	TO
cord-258536-qnn9hp8e	202	14	be	be	VB
cord-258536-qnn9hp8e	202	15	complex	complex	JJ
cord-258536-qnn9hp8e	202	16	.	.	.
cord-258536-qnn9hp8e	203	1	Although	although	IN
cord-258536-qnn9hp8e	203	2	MHV	MHV	NNP
cord-258536-qnn9hp8e	203	3	hijacking	hijacking	NN
cord-258536-qnn9hp8e	203	4	of	of	IN
cord-258536-qnn9hp8e	203	5	LC3-positive	lc3-positive	JJ
cord-258536-qnn9hp8e	203	6	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	203	7	for	for	IN
cord-258536-qnn9hp8e	203	8	its	-PRON-	PRP$
cord-258536-qnn9hp8e	203	9	replication	replication	NN
cord-258536-qnn9hp8e	203	10	appears	appear	VBZ
cord-258536-qnn9hp8e	203	11	to	to	TO
cord-258536-qnn9hp8e	203	12	be	be	VB
cord-258536-qnn9hp8e	203	13	clearly	clearly	RB
cord-258536-qnn9hp8e	203	14	established	establish	VBN
cord-258536-qnn9hp8e	203	15	,	,	,
cord-258536-qnn9hp8e	203	16	this	this	DT
cord-258536-qnn9hp8e	203	17	finding	finding	NN
cord-258536-qnn9hp8e	203	18	has	have	VBZ
cord-258536-qnn9hp8e	203	19	not	not	RB
cord-258536-qnn9hp8e	203	20	yet	yet	RB
cord-258536-qnn9hp8e	203	21	been	be	VBN
cord-258536-qnn9hp8e	203	22	extended	extend	VBN
cord-258536-qnn9hp8e	203	23	to	to	IN
cord-258536-qnn9hp8e	203	24	other	other	JJ
cord-258536-qnn9hp8e	203	25	beta	beta	NN
cord-258536-qnn9hp8e	203	26	-	-	HYPH
cord-258536-qnn9hp8e	203	27	CoV	cov	NN
cord-258536-qnn9hp8e	203	28	or	or	CC
cord-258536-qnn9hp8e	203	29	to	to	IN
cord-258536-qnn9hp8e	203	30	other	other	JJ
cord-258536-qnn9hp8e	203	31	CoV	cov	NN
cord-258536-qnn9hp8e	203	32	in	in	IN
cord-258536-qnn9hp8e	203	33	general	general	NN
cord-258536-qnn9hp8e	203	34	.	.	.
cord-258536-qnn9hp8e	204	1	Co	co	NN
cord-258536-qnn9hp8e	204	2	-	-	NN
cord-258536-qnn9hp8e	204	3	localization	localization	NN
cord-258536-qnn9hp8e	204	4	between	between	IN
cord-258536-qnn9hp8e	204	5	SARS	SARS	NNP
cord-258536-qnn9hp8e	204	6	-	-	HYPH
cord-258536-qnn9hp8e	204	7	CoV	CoV	NNP
cord-258536-qnn9hp8e	204	8	RTCs	rtc	NNS
cord-258536-qnn9hp8e	204	9	and	and	CC
cord-258536-qnn9hp8e	204	10	endogenous	endogenous	JJ
cord-258536-qnn9hp8e	204	11	LC3	lc3	NN
cord-258536-qnn9hp8e	204	12	,	,	,
cord-258536-qnn9hp8e	204	13	however	however	RB
cord-258536-qnn9hp8e	204	14	,	,	,
cord-258536-qnn9hp8e	204	15	has	have	VBZ
cord-258536-qnn9hp8e	204	16	been	be	VBN
cord-258536-qnn9hp8e	204	17	reported	report	VBN
cord-258536-qnn9hp8e	204	18	[	[	-LRB-
cord-258536-qnn9hp8e	204	19	81	81	CD
cord-258536-qnn9hp8e	204	20	]	]	-RRB-
cord-258536-qnn9hp8e	204	21	.	.	.
cord-258536-qnn9hp8e	205	1	Beta	beta	NN
cord-258536-qnn9hp8e	205	2	-	-	HYPH
cord-258536-qnn9hp8e	205	3	CoV	cov	NN
cord-258536-qnn9hp8e	205	4	do	do	VBP
cord-258536-qnn9hp8e	205	5	not	not	RB
cord-258536-qnn9hp8e	205	6	require	require	VB
cord-258536-qnn9hp8e	205	7	canonical	canonical	JJ
cord-258536-qnn9hp8e	205	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	205	9	for	for	IN
cord-258536-qnn9hp8e	205	10	their	-PRON-	PRP$
cord-258536-qnn9hp8e	205	11	life	life	NN
cord-258536-qnn9hp8e	205	12	cycle	cycle	NN
cord-258536-qnn9hp8e	205	13	[	[	-LRB-
cord-258536-qnn9hp8e	205	14	65	65	CD
cord-258536-qnn9hp8e	205	15	]	]	-RRB-
cord-258536-qnn9hp8e	205	16	[	[	-LRB-
cord-258536-qnn9hp8e	205	17	66	66	CD
cord-258536-qnn9hp8e	205	18	]	]	-RRB-
cord-258536-qnn9hp8e	206	1	[	[	-LRB-
cord-258536-qnn9hp8e	206	2	67	67	CD
cord-258536-qnn9hp8e	206	3	]	]	-RRB-
cord-258536-qnn9hp8e	207	1	but	but	CC
cord-258536-qnn9hp8e	207	2	it	-PRON-	PRP
cord-258536-qnn9hp8e	207	3	can	can	MD
cord-258536-qnn9hp8e	207	4	not	not	RB
cord-258536-qnn9hp8e	207	5	be	be	VB
cord-258536-qnn9hp8e	207	6	excluded	exclude	VBN
cord-258536-qnn9hp8e	208	1	a	a	DT
cord-258536-qnn9hp8e	208	2	priori	priori	FW
cord-258536-qnn9hp8e	208	3	that	that	IN
cord-258536-qnn9hp8e	208	4	they	-PRON-	PRP
cord-258536-qnn9hp8e	208	5	could	could	MD
cord-258536-qnn9hp8e	208	6	need	need	VB
cord-258536-qnn9hp8e	208	7	a	a	DT
cord-258536-qnn9hp8e	208	8	non	non	JJ
cord-258536-qnn9hp8e	208	9	-	-	JJ
cord-258536-qnn9hp8e	208	10	canonical	canonical	JJ
cord-258536-qnn9hp8e	208	11	form	form	NN
cord-258536-qnn9hp8e	208	12	of	of	IN
cord-258536-qnn9hp8e	208	13	autophagy	autophagy	NN
cord-258536-qnn9hp8e	208	14	,	,	,
cord-258536-qnn9hp8e	208	15	independent	independent	JJ
cord-258536-qnn9hp8e	208	16	from	from	IN
cord-258536-qnn9hp8e	208	17	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	208	18	and	and	CC
cord-258536-qnn9hp8e	208	19	ATG7	ATG7	NNP
cord-258536-qnn9hp8e	208	20	[	[	-LRB-
cord-258536-qnn9hp8e	208	21	87	87	CD
cord-258536-qnn9hp8e	208	22	]	]	-RRB-
cord-258536-qnn9hp8e	208	23	.	.	.
cord-258536-qnn9hp8e	209	1	Furthermore	furthermore	RB
cord-258536-qnn9hp8e	209	2	,	,	,
cord-258536-qnn9hp8e	209	3	while	while	IN
cord-258536-qnn9hp8e	209	4	autophagy	autophagy	NN
cord-258536-qnn9hp8e	209	5	might	may	MD
cord-258536-qnn9hp8e	209	6	be	be	VB
cord-258536-qnn9hp8e	209	7	induced	induce	VBN
cord-258536-qnn9hp8e	209	8	during	during	IN
cord-258536-qnn9hp8e	209	9	infection	infection	NN
cord-258536-qnn9hp8e	209	10	or	or	CC
cord-258536-qnn9hp8e	209	11	transient	transient	JJ
cord-258536-qnn9hp8e	209	12	expression	expression	NN
cord-258536-qnn9hp8e	209	13	of	of	IN
cord-258536-qnn9hp8e	209	14	single	single	JJ
cord-258536-qnn9hp8e	209	15	viral	viral	JJ
cord-258536-qnn9hp8e	209	16	proteins	protein	NNS
cord-258536-qnn9hp8e	209	17	[	[	-LRB-
cord-258536-qnn9hp8e	209	18	65	65	CD
cord-258536-qnn9hp8e	209	19	,	,	,
cord-258536-qnn9hp8e	209	20	88	88	CD
cord-258536-qnn9hp8e	209	21	]	]	-RRB-
cord-258536-qnn9hp8e	209	22	,	,	,
cord-258536-qnn9hp8e	209	23	there	there	EX
cord-258536-qnn9hp8e	209	24	is	be	VBZ
cord-258536-qnn9hp8e	209	25	currently	currently	RB
cord-258536-qnn9hp8e	209	26	no	no	DT
cord-258536-qnn9hp8e	209	27	evidence	evidence	NN
cord-258536-qnn9hp8e	209	28	that	that	IN
cord-258536-qnn9hp8e	209	29	this	this	DT
cord-258536-qnn9hp8e	209	30	is	be	VBZ
cord-258536-qnn9hp8e	209	31	directly	directly	RB
cord-258536-qnn9hp8e	209	32	regulated	regulate	VBN
cord-258536-qnn9hp8e	209	33	by	by	IN
cord-258536-qnn9hp8e	209	34	beta	beta	NN
cord-258536-qnn9hp8e	209	35	-	-	HYPH
cord-258536-qnn9hp8e	209	36	CoV.	CoV.	NNP
cord-258536-qnn9hp8e	210	1	Indeed	indeed	RB
cord-258536-qnn9hp8e	210	2	,	,	,
cord-258536-qnn9hp8e	210	3	autophagy	autophagy	NN
cord-258536-qnn9hp8e	210	4	stimulation	stimulation	NN
cord-258536-qnn9hp8e	210	5	could	could	MD
cord-258536-qnn9hp8e	210	6	be	be	VB
cord-258536-qnn9hp8e	210	7	part	part	NN
cord-258536-qnn9hp8e	210	8	of	of	IN
cord-258536-qnn9hp8e	210	9	a	a	DT
cord-258536-qnn9hp8e	210	10	cellular	cellular	JJ
cord-258536-qnn9hp8e	210	11	response	response	NN
cord-258536-qnn9hp8e	210	12	caused	cause	VBN
cord-258536-qnn9hp8e	210	13	by	by	IN
cord-258536-qnn9hp8e	210	14	either	either	CC
cord-258536-qnn9hp8e	210	15	the	the	DT
cord-258536-qnn9hp8e	210	16	presence	presence	NN
cord-258536-qnn9hp8e	210	17	of	of	IN
cord-258536-qnn9hp8e	210	18	toxic	toxic	JJ
cord-258536-qnn9hp8e	210	19	exogenous	exogenous	JJ
cord-258536-qnn9hp8e	210	20	proteins	protein	NNS
cord-258536-qnn9hp8e	210	21	or	or	CC
cord-258536-qnn9hp8e	210	22	ER	ER	NNP
cord-258536-qnn9hp8e	210	23	stress	stress	NN
cord-258536-qnn9hp8e	210	24	induced	induce	VBN
cord-258536-qnn9hp8e	210	25	by	by	IN
cord-258536-qnn9hp8e	210	26	the	the	DT
cord-258536-qnn9hp8e	210	27	massive	massive	JJ
cord-258536-qnn9hp8e	210	28	production	production	NN
cord-258536-qnn9hp8e	210	29	of	of	IN
cord-258536-qnn9hp8e	210	30	viral	viral	JJ
cord-258536-qnn9hp8e	210	31	proteins	protein	NNS
cord-258536-qnn9hp8e	210	32	[	[	-LRB-
cord-258536-qnn9hp8e	210	33	89	89	CD
cord-258536-qnn9hp8e	210	34	]	]	-RRB-
cord-258536-qnn9hp8e	211	1	[	[	-LRB-
cord-258536-qnn9hp8e	211	2	90	90	CD
cord-258536-qnn9hp8e	211	3	]	]	-RRB-
cord-258536-qnn9hp8e	211	4	[	[	-LRB-
cord-258536-qnn9hp8e	211	5	91	91	CD
cord-258536-qnn9hp8e	211	6	]	]	-RRB-
cord-258536-qnn9hp8e	211	7	.	.	.
cord-258536-qnn9hp8e	212	1	A	a	DT
cord-258536-qnn9hp8e	212	2	recent	recent	JJ
cord-258536-qnn9hp8e	212	3	study	study	NN
cord-258536-qnn9hp8e	212	4	concluded	conclude	VBD
cord-258536-qnn9hp8e	212	5	that	that	IN
cord-258536-qnn9hp8e	212	6	expression	expression	NN
cord-258536-qnn9hp8e	212	7	of	of	IN
cord-258536-qnn9hp8e	212	8	nsp3	nsp3	NNS
cord-258536-qnn9hp8e	212	9	fragments	fragment	NNS
cord-258536-qnn9hp8e	212	10	derived	derive	VBN
cord-258536-qnn9hp8e	212	11	from	from	IN
cord-258536-qnn9hp8e	212	12	several	several	JJ
cord-258536-qnn9hp8e	212	13	CoV	cov	NN
cord-258536-qnn9hp8e	212	14	,	,	,
cord-258536-qnn9hp8e	212	15	which	which	WDT
cord-258536-qnn9hp8e	212	16	comprise	comprise	VBP
cord-258536-qnn9hp8e	212	17	the	the	DT
cord-258536-qnn9hp8e	212	18	papain	papain	NN
cord-258536-qnn9hp8e	212	19	-	-	HYPH
cord-258536-qnn9hp8e	212	20	like	like	JJ
cord-258536-qnn9hp8e	212	21	protease	protease	NN
cord-258536-qnn9hp8e	212	22	domain	domain	NN
cord-258536-qnn9hp8e	212	23	and	and	CC
cord-258536-qnn9hp8e	212	24	one	one	CD
cord-258536-qnn9hp8e	212	25	transmembrane	transmembrane	NN
cord-258536-qnn9hp8e	212	26	segment	segment	NN
cord-258536-qnn9hp8e	212	27	,	,	,
cord-258536-qnn9hp8e	212	28	induce	induce	VB
cord-258536-qnn9hp8e	212	29	autophagy	autophagy	NN
cord-258536-qnn9hp8e	212	30	through	through	IN
cord-258536-qnn9hp8e	212	31	direct	direct	JJ
cord-258536-qnn9hp8e	212	32	binding	binding	NN
cord-258536-qnn9hp8e	212	33	to	to	IN
cord-258536-qnn9hp8e	212	34	LC3	LC3	NNP
cord-258536-qnn9hp8e	212	35	and	and	CC
cord-258536-qnn9hp8e	212	36	BECLIN1	BECLIN1	NNS
cord-258536-qnn9hp8e	212	37	[	[	-LRB-
cord-258536-qnn9hp8e	212	38	92	92	CD
cord-258536-qnn9hp8e	212	39	]	]	-RRB-
cord-258536-qnn9hp8e	212	40	.	.	.
cord-258536-qnn9hp8e	213	1	This	this	DT
cord-258536-qnn9hp8e	213	2	conclusion	conclusion	NN
cord-258536-qnn9hp8e	213	3	,	,	,
cord-258536-qnn9hp8e	213	4	however	however	RB
cord-258536-qnn9hp8e	213	5	,	,	,
cord-258536-qnn9hp8e	213	6	has	have	VBZ
cord-258536-qnn9hp8e	213	7	to	to	TO
cord-258536-qnn9hp8e	213	8	be	be	VB
cord-258536-qnn9hp8e	213	9	carefully	carefully	RB
cord-258536-qnn9hp8e	213	10	considered	consider	VBN
cord-258536-qnn9hp8e	213	11	since	since	IN
cord-258536-qnn9hp8e	213	12	the	the	DT
cord-258536-qnn9hp8e	213	13	authors	author	NNS
cord-258536-qnn9hp8e	213	14	of	of	IN
cord-258536-qnn9hp8e	213	15	this	this	DT
cord-258536-qnn9hp8e	213	16	study	study	NN
cord-258536-qnn9hp8e	213	17	observed	observe	VBD
cord-258536-qnn9hp8e	213	18	GFP	GFP	NNP
cord-258536-qnn9hp8e	213	19	-	-	HYPH
cord-258536-qnn9hp8e	213	20	LC3	lc3	JJ
cord-258536-qnn9hp8e	213	21	puncta	puncta	NN
cord-258536-qnn9hp8e	213	22	formation	formation	NN
cord-258536-qnn9hp8e	213	23	in	in	IN
cord-258536-qnn9hp8e	213	24	cells	cell	NNS
cord-258536-qnn9hp8e	213	25	ectopically	ectopically	RB
cord-258536-qnn9hp8e	213	26	expressing	express	VBG
cord-258536-qnn9hp8e	213	27	the	the	DT
cord-258536-qnn9hp8e	213	28	nsp3	nsp3	NNS
cord-258536-qnn9hp8e	213	29	fragment	fragment	NN
cord-258536-qnn9hp8e	214	1	but	but	CC
cord-258536-qnn9hp8e	214	2	they	-PRON-	PRP
cord-258536-qnn9hp8e	214	3	did	do	VBD
cord-258536-qnn9hp8e	214	4	not	not	RB
cord-258536-qnn9hp8e	214	5	examine	examine	VB
cord-258536-qnn9hp8e	214	6	whether	whether	IN
cord-258536-qnn9hp8e	214	7	these	these	DT
cord-258536-qnn9hp8e	214	8	puncta	puncta	NN
cord-258536-qnn9hp8e	214	9	are	be	VBP
cord-258536-qnn9hp8e	214	10	indeed	indeed	RB
cord-258536-qnn9hp8e	214	11	autophagosomes	autophagosomes	JJ
cord-258536-qnn9hp8e	214	12	.	.	.
cord-258536-qnn9hp8e	215	1	Moreover	moreover	RB
cord-258536-qnn9hp8e	215	2	,	,	,
cord-258536-qnn9hp8e	215	3	the	the	DT
cord-258536-qnn9hp8e	215	4	relevance	relevance	NN
cord-258536-qnn9hp8e	215	5	of	of	IN
cord-258536-qnn9hp8e	215	6	the	the	DT
cord-258536-qnn9hp8e	215	7	use	use	NN
cord-258536-qnn9hp8e	215	8	of	of	IN
cord-258536-qnn9hp8e	215	9	a	a	DT
cord-258536-qnn9hp8e	215	10	truncated	truncated	JJ
cord-258536-qnn9hp8e	215	11	form	form	NN
cord-258536-qnn9hp8e	215	12	of	of	IN
cord-258536-qnn9hp8e	215	13	nsp3	nsp3	NNS
cord-258536-qnn9hp8e	215	14	in	in	IN
cord-258536-qnn9hp8e	215	15	absence	absence	NN
cord-258536-qnn9hp8e	215	16	of	of	IN
cord-258536-qnn9hp8e	215	17	a	a	DT
cord-258536-qnn9hp8e	215	18	CoV	cov	NN
cord-258536-qnn9hp8e	215	19	infection	infection	NN
cord-258536-qnn9hp8e	215	20	remains	remain	VBZ
cord-258536-qnn9hp8e	215	21	to	to	TO
cord-258536-qnn9hp8e	215	22	be	be	VB
cord-258536-qnn9hp8e	215	23	determined	determine	VBN
cord-258536-qnn9hp8e	215	24	.	.	.
cord-258536-qnn9hp8e	216	1	Additional	additional	JJ
cord-258536-qnn9hp8e	216	2	studies	study	NNS
cord-258536-qnn9hp8e	216	3	are	be	VBP
cord-258536-qnn9hp8e	216	4	thus	thus	RB
cord-258536-qnn9hp8e	216	5	needed	need	VBN
cord-258536-qnn9hp8e	216	6	to	to	TO
cord-258536-qnn9hp8e	216	7	address	address	VB
cord-258536-qnn9hp8e	216	8	the	the	DT
cord-258536-qnn9hp8e	216	9	questions	question	NNS
cord-258536-qnn9hp8e	216	10	if	if	IN
cord-258536-qnn9hp8e	216	11	and	and	CC
cord-258536-qnn9hp8e	216	12	,	,	,
cord-258536-qnn9hp8e	216	13	eventually	eventually	RB
cord-258536-qnn9hp8e	216	14	,	,	,
cord-258536-qnn9hp8e	216	15	how	how	WRB
cord-258536-qnn9hp8e	216	16	beta	beta	NN
cord-258536-qnn9hp8e	216	17	-	-	HYPH
cord-258536-qnn9hp8e	216	18	CoV	cov	NN
cord-258536-qnn9hp8e	216	19	trigger	trigger	NN
cord-258536-qnn9hp8e	216	20	autophagy	autophagy	NN
cord-258536-qnn9hp8e	216	21	.	.	.
cord-258536-qnn9hp8e	217	1	Gammacoronaviruses	Gammacoronaviruses	NNP
cord-258536-qnn9hp8e	217	2	(	(	-LRB-
cord-258536-qnn9hp8e	217	3	gamma	gamma	NN
cord-258536-qnn9hp8e	217	4	-	-	HYPH
cord-258536-qnn9hp8e	217	5	CoVs	CoVs	NNP
cord-258536-qnn9hp8e	217	6	)	)	-RRB-
cord-258536-qnn9hp8e	217	7	are	be	VBP
cord-258536-qnn9hp8e	217	8	viruses	virus	NNS
cord-258536-qnn9hp8e	217	9	that	that	WDT
cord-258536-qnn9hp8e	217	10	mainly	mainly	RB
cord-258536-qnn9hp8e	217	11	infect	infect	VBP
cord-258536-qnn9hp8e	217	12	poultry	poultry	NN
cord-258536-qnn9hp8e	217	13	but	but	CC
cord-258536-qnn9hp8e	217	14	are	be	VBP
cord-258536-qnn9hp8e	217	15	also	also	RB
cord-258536-qnn9hp8e	217	16	transmissible	transmissible	JJ
cord-258536-qnn9hp8e	217	17	to	to	IN
cord-258536-qnn9hp8e	217	18	humans	human	NNS
cord-258536-qnn9hp8e	217	19	.	.	.
cord-258536-qnn9hp8e	218	1	They	-PRON-	PRP
cord-258536-qnn9hp8e	218	2	replicate	replicate	VBP
cord-258536-qnn9hp8e	218	3	in	in	IN
cord-258536-qnn9hp8e	218	4	the	the	DT
cord-258536-qnn9hp8e	218	5	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	218	6	tract	tract	NN
cord-258536-qnn9hp8e	218	7	and	and	CC
cord-258536-qnn9hp8e	218	8	thus	thus	RB
cord-258536-qnn9hp8e	218	9	cause	cause	VB
cord-258536-qnn9hp8e	218	10	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	218	11	defects	defect	NNS
cord-258536-qnn9hp8e	218	12	.	.	.
cord-258536-qnn9hp8e	219	1	The	the	DT
cord-258536-qnn9hp8e	219	2	Infectious	Infectious	NNP
cord-258536-qnn9hp8e	219	3	Bronchitis	Bronchitis	NNP
cord-258536-qnn9hp8e	219	4	Virus	Virus	NNP
cord-258536-qnn9hp8e	219	5	,	,	,
cord-258536-qnn9hp8e	219	6	which	which	WDT
cord-258536-qnn9hp8e	219	7	causes	cause	VBZ
cord-258536-qnn9hp8e	219	8	major	major	JJ
cord-258536-qnn9hp8e	219	9	loses	lose	NNS
cord-258536-qnn9hp8e	219	10	in	in	IN
cord-258536-qnn9hp8e	219	11	the	the	DT
cord-258536-qnn9hp8e	219	12	poultry	poultry	NN
cord-258536-qnn9hp8e	219	13	industry	industry	NN
cord-258536-qnn9hp8e	219	14	,	,	,
cord-258536-qnn9hp8e	219	15	is	be	VBZ
cord-258536-qnn9hp8e	219	16	the	the	DT
cord-258536-qnn9hp8e	219	17	model	model	NN
cord-258536-qnn9hp8e	219	18	virus	virus	NN
cord-258536-qnn9hp8e	219	19	for	for	IN
cord-258536-qnn9hp8e	220	1	gamma	gamma	NNP
cord-258536-qnn9hp8e	220	2	-	-	HYPH
cord-258536-qnn9hp8e	220	3	CoV.	CoV.	NNP
cord-258536-qnn9hp8e	220	4	Similarly	similarly	RB
cord-258536-qnn9hp8e	220	5	to	to	IN
cord-258536-qnn9hp8e	220	6	other	other	JJ
cord-258536-qnn9hp8e	220	7	CoV	cov	NN
cord-258536-qnn9hp8e	220	8	,	,	,
cord-258536-qnn9hp8e	220	9	the	the	DT
cord-258536-qnn9hp8e	220	10	IBV	IBV	NNP
cord-258536-qnn9hp8e	220	11	genome	genome	NN
cord-258536-qnn9hp8e	220	12	encodes	encode	VBZ
cord-258536-qnn9hp8e	220	13	several	several	JJ
cord-258536-qnn9hp8e	220	14	nsp	nsp	NN
cord-258536-qnn9hp8e	220	15	proteins	protein	NNS
cord-258536-qnn9hp8e	220	16	that	that	WDT
cord-258536-qnn9hp8e	220	17	help	help	VBP
cord-258536-qnn9hp8e	220	18	with	with	IN
cord-258536-qnn9hp8e	220	19	replication	replication	NN
cord-258536-qnn9hp8e	220	20	and	and	CC
cord-258536-qnn9hp8e	220	21	interfere	interfere	VB
cord-258536-qnn9hp8e	220	22	with	with	IN
cord-258536-qnn9hp8e	220	23	host	host	NN
cord-258536-qnn9hp8e	220	24	cell	cell	NN
cord-258536-qnn9hp8e	220	25	functions	function	NNS
cord-258536-qnn9hp8e	220	26	.	.	.
cord-258536-qnn9hp8e	221	1	Cottam	Cottam	NNP
cord-258536-qnn9hp8e	221	2	et	et	NNP
cord-258536-qnn9hp8e	221	3	al	al	NNP
cord-258536-qnn9hp8e	221	4	.	.	NNP
cord-258536-qnn9hp8e	221	5	have	have	VBP
cord-258536-qnn9hp8e	221	6	reported	report	VBN
cord-258536-qnn9hp8e	221	7	that	that	IN
cord-258536-qnn9hp8e	221	8	infections	infection	NNS
cord-258536-qnn9hp8e	221	9	with	with	IN
cord-258536-qnn9hp8e	221	10	IBV	IBV	NNP
cord-258536-qnn9hp8e	221	11	trigger	trigger	VB
cord-258536-qnn9hp8e	221	12	the	the	DT
cord-258536-qnn9hp8e	221	13	formation	formation	NN
cord-258536-qnn9hp8e	221	14	of	of	IN
cord-258536-qnn9hp8e	221	15	endogenous	endogenous	JJ
cord-258536-qnn9hp8e	221	16	LC3-positive	lc3-positive	JJ
cord-258536-qnn9hp8e	221	17	puncta	puncta	NN
cord-258536-qnn9hp8e	221	18	in	in	IN
cord-258536-qnn9hp8e	221	19	host	host	NN
cord-258536-qnn9hp8e	221	20	cells	cell	NNS
cord-258536-qnn9hp8e	221	21	[	[	-LRB-
cord-258536-qnn9hp8e	221	22	88	88	CD
cord-258536-qnn9hp8e	221	23	,	,	,
cord-258536-qnn9hp8e	221	24	93	93	CD
cord-258536-qnn9hp8e	221	25	]	]	-RRB-
cord-258536-qnn9hp8e	221	26	.	.	.
cord-258536-qnn9hp8e	222	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	222	2	,	,	,
cord-258536-qnn9hp8e	222	3	they	-PRON-	PRP
cord-258536-qnn9hp8e	222	4	noted	note	VBD
cord-258536-qnn9hp8e	222	5	that	that	IN
cord-258536-qnn9hp8e	222	6	a	a	DT
cord-258536-qnn9hp8e	222	7	fraction	fraction	NN
cord-258536-qnn9hp8e	222	8	of	of	IN
cord-258536-qnn9hp8e	222	9	these	these	DT
cord-258536-qnn9hp8e	222	10	puncta	puncta	NN
cord-258536-qnn9hp8e	222	11	partially	partially	RB
cord-258536-qnn9hp8e	222	12	co	co	VBD
cord-258536-qnn9hp8e	222	13	-	-	VBN
cord-258536-qnn9hp8e	222	14	localized	localize	VBN
cord-258536-qnn9hp8e	222	15	with	with	IN
cord-258536-qnn9hp8e	222	16	double	double	JJ
cord-258536-qnn9hp8e	222	17	stranded	strand	VBN
cord-258536-qnn9hp8e	222	18	viral	viral	JJ
cord-258536-qnn9hp8e	222	19	RNA	RNA	NNP
cord-258536-qnn9hp8e	222	20	.	.	.
cord-258536-qnn9hp8e	223	1	By	by	IN
cord-258536-qnn9hp8e	223	2	screening	screen	VBG
cord-258536-qnn9hp8e	223	3	several	several	JJ
cord-258536-qnn9hp8e	223	4	IBV	IBV	NNP
cord-258536-qnn9hp8e	223	5	nsp	nsp	NN
cord-258536-qnn9hp8e	223	6	proteins	protein	NNS
cord-258536-qnn9hp8e	223	7	,	,	,
cord-258536-qnn9hp8e	223	8	they	-PRON-	PRP
cord-258536-qnn9hp8e	223	9	found	find	VBD
cord-258536-qnn9hp8e	223	10	that	that	IN
cord-258536-qnn9hp8e	223	11	ectopically	ectopically	RB
cord-258536-qnn9hp8e	223	12	expressed	express	VBD
cord-258536-qnn9hp8e	223	13	nsp6	nsp6	NN
cord-258536-qnn9hp8e	223	14	localized	localize	VBN
cord-258536-qnn9hp8e	223	15	with	with	IN
cord-258536-qnn9hp8e	223	16	the	the	DT
cord-258536-qnn9hp8e	223	17	ER	ER	NNP
cord-258536-qnn9hp8e	223	18	and	and	CC
cord-258536-qnn9hp8e	223	19	was	be	VBD
cord-258536-qnn9hp8e	223	20	able	able	JJ
cord-258536-qnn9hp8e	223	21	to	to	TO
cord-258536-qnn9hp8e	223	22	autonomously	autonomously	RB
cord-258536-qnn9hp8e	223	23	induce	induce	VB
cord-258536-qnn9hp8e	223	24	the	the	DT
cord-258536-qnn9hp8e	223	25	formation	formation	NN
cord-258536-qnn9hp8e	223	26	of	of	IN
cord-258536-qnn9hp8e	223	27	GFP	GFP	NNP
cord-258536-qnn9hp8e	223	28	-	-	HYPH
cord-258536-qnn9hp8e	223	29	LC3	lc3	JJ
cord-258536-qnn9hp8e	223	30	puncta	puncta	NN
cord-258536-qnn9hp8e	223	31	.	.	.
cord-258536-qnn9hp8e	224	1	This	this	DT
cord-258536-qnn9hp8e	224	2	raised	raise	VBD
cord-258536-qnn9hp8e	224	3	the	the	DT
cord-258536-qnn9hp8e	224	4	question	question	NN
cord-258536-qnn9hp8e	224	5	whether	whether	IN
cord-258536-qnn9hp8e	224	6	the	the	DT
cord-258536-qnn9hp8e	224	7	GFP	GFP	NNP
cord-258536-qnn9hp8e	224	8	-	-	HYPH
cord-258536-qnn9hp8e	224	9	LC3	lc3	JJ
cord-258536-qnn9hp8e	224	10	puncta	puncta	NN
cord-258536-qnn9hp8e	224	11	induced	induce	VBN
cord-258536-qnn9hp8e	224	12	by	by	IN
cord-258536-qnn9hp8e	224	13	nsp6	nsp6	NN
cord-258536-qnn9hp8e	224	14	were	be	VBD
cord-258536-qnn9hp8e	224	15	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	224	16	[	[	-LRB-
cord-258536-qnn9hp8e	224	17	67	67	CD
cord-258536-qnn9hp8e	224	18	]	]	-RRB-
cord-258536-qnn9hp8e	224	19	.	.	.
cord-258536-qnn9hp8e	225	1	In	in	IN
cord-258536-qnn9hp8e	225	2	contrast	contrast	NN
cord-258536-qnn9hp8e	225	3	to	to	IN
cord-258536-qnn9hp8e	225	4	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	225	5	,	,	,
cord-258536-qnn9hp8e	225	6	however	however	RB
cord-258536-qnn9hp8e	225	7	,	,	,
cord-258536-qnn9hp8e	225	8	formation	formation	NN
cord-258536-qnn9hp8e	225	9	of	of	IN
cord-258536-qnn9hp8e	225	10	these	these	DT
cord-258536-qnn9hp8e	225	11	GFP	GFP	NNP
cord-258536-qnn9hp8e	225	12	-	-	HYPH
cord-258536-qnn9hp8e	225	13	LC3-positive	lc3-positive	NN
cord-258536-qnn9hp8e	225	14	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	225	15	required	require	VBD
cord-258536-qnn9hp8e	225	16	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	225	17	and	and	CC
cord-258536-qnn9hp8e	225	18	LC3	LC3	NNP
cord-258536-qnn9hp8e	225	19	lipidation	lipidation	NN
cord-258536-qnn9hp8e	225	20	,	,	,
cord-258536-qnn9hp8e	225	21	suggesting	suggest	VBG
cord-258536-qnn9hp8e	225	22	that	that	IN
cord-258536-qnn9hp8e	225	23	they	-PRON-	PRP
cord-258536-qnn9hp8e	225	24	are	be	VBP
cord-258536-qnn9hp8e	225	25	canonical	canonical	JJ
cord-258536-qnn9hp8e	225	26	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	225	27	[	[	-LRB-
cord-258536-qnn9hp8e	225	28	56	56	CD
cord-258536-qnn9hp8e	225	29	,	,	,
cord-258536-qnn9hp8e	225	30	67	67	CD
cord-258536-qnn9hp8e	225	31	,	,	,
cord-258536-qnn9hp8e	225	32	88	88	CD
cord-258536-qnn9hp8e	225	33	]	]	-RRB-
cord-258536-qnn9hp8e	225	34	.	.	.
cord-258536-qnn9hp8e	226	1	Interestingly	interestingly	RB
cord-258536-qnn9hp8e	226	2	,	,	,
cord-258536-qnn9hp8e	226	3	nsp6	nsp6	NN
cord-258536-qnn9hp8e	226	4	from	from	IN
cord-258536-qnn9hp8e	226	5	MHV	MHV	NNP
cord-258536-qnn9hp8e	226	6	and	and	CC
cord-258536-qnn9hp8e	226	7	SARS	SARS	NNP
cord-258536-qnn9hp8e	226	8	-	-	HYPH
cord-258536-qnn9hp8e	226	9	CoV	CoV	NNP
cord-258536-qnn9hp8e	226	10	also	also	RB
cord-258536-qnn9hp8e	226	11	induced	induce	VBD
cord-258536-qnn9hp8e	226	12	GFP	GFP	NNP
cord-258536-qnn9hp8e	226	13	-	-	HYPH
cord-258536-qnn9hp8e	226	14	LC3	lc3	JJ
cord-258536-qnn9hp8e	226	15	puncta	puncta	NN
cord-258536-qnn9hp8e	226	16	formation	formation	NN
cord-258536-qnn9hp8e	226	17	indicating	indicate	VBG
cord-258536-qnn9hp8e	226	18	that	that	IN
cord-258536-qnn9hp8e	226	19	the	the	DT
cord-258536-qnn9hp8e	226	20	nsp6-dependent	nsp6-dependent	NNP
cord-258536-qnn9hp8e	226	21	mechanism	mechanism	NN
cord-258536-qnn9hp8e	226	22	for	for	IN
cord-258536-qnn9hp8e	226	23	autophagy	autophagy	NN
cord-258536-qnn9hp8e	226	24	induction	induction	NN
cord-258536-qnn9hp8e	226	25	might	may	MD
cord-258536-qnn9hp8e	226	26	be	be	VB
cord-258536-qnn9hp8e	226	27	conserved	conserve	VBN
cord-258536-qnn9hp8e	226	28	among	among	IN
cord-258536-qnn9hp8e	226	29	CoVs	CoVs	NNP
cord-258536-qnn9hp8e	226	30	.	.	.
cord-258536-qnn9hp8e	227	1	Cottam	Cottam	NNP
cord-258536-qnn9hp8e	227	2	et	et	NNP
cord-258536-qnn9hp8e	227	3	al	al	NNP
cord-258536-qnn9hp8e	227	4	.	.	.
cord-258536-qnn9hp8e	227	5	also	also	RB
cord-258536-qnn9hp8e	227	6	argued	argue	VBD
cord-258536-qnn9hp8e	227	7	that	that	IN
cord-258536-qnn9hp8e	227	8	nsp6	nsp6	NN
cord-258536-qnn9hp8e	227	9	might	may	MD
cord-258536-qnn9hp8e	227	10	reduce	reduce	VB
cord-258536-qnn9hp8e	227	11	the	the	DT
cord-258536-qnn9hp8e	227	12	expansion	expansion	NN
cord-258536-qnn9hp8e	227	13	of	of	IN
cord-258536-qnn9hp8e	227	14	the	the	DT
cord-258536-qnn9hp8e	227	15	autophagosomes	autophagosomes	NNP
cord-258536-qnn9hp8e	227	16	as	as	RB
cord-258536-qnn9hp8e	227	17	well	well	RB
cord-258536-qnn9hp8e	227	18	,	,	,
cord-258536-qnn9hp8e	227	19	while	while	IN
cord-258536-qnn9hp8e	227	20	maturation	maturation	NN
cord-258536-qnn9hp8e	227	21	into	into	IN
cord-258536-qnn9hp8e	227	22	autolysosomes	autolysosome	NNS
cord-258536-qnn9hp8e	227	23	is	be	VBZ
cord-258536-qnn9hp8e	227	24	still	still	RB
cord-258536-qnn9hp8e	227	25	possible	possible	JJ
cord-258536-qnn9hp8e	227	26	[	[	-LRB-
cord-258536-qnn9hp8e	227	27	93	93	CD
cord-258536-qnn9hp8e	227	28	]	]	-RRB-
cord-258536-qnn9hp8e	227	29	.	.	.
cord-258536-qnn9hp8e	228	1	These	these	DT
cord-258536-qnn9hp8e	228	2	results	result	NNS
cord-258536-qnn9hp8e	228	3	have	have	VBP
cord-258536-qnn9hp8e	228	4	been	be	VBN
cord-258536-qnn9hp8e	228	5	obtained	obtain	VBN
cord-258536-qnn9hp8e	228	6	using	use	VBG
cord-258536-qnn9hp8e	228	7	ectopic	ectopic	JJ
cord-258536-qnn9hp8e	228	8	expression	expression	NN
cord-258536-qnn9hp8e	228	9	of	of	IN
cord-258536-qnn9hp8e	228	10	nsp6	nsp6	NN
cord-258536-qnn9hp8e	228	11	and	and	CC
cord-258536-qnn9hp8e	228	12	thus	thus	RB
cord-258536-qnn9hp8e	228	13	the	the	DT
cord-258536-qnn9hp8e	228	14	relevance	relevance	NN
cord-258536-qnn9hp8e	228	15	of	of	IN
cord-258536-qnn9hp8e	228	16	nsp6-mediated	nsp6-mediate	VBN
cord-258536-qnn9hp8e	228	17	induction	induction	NN
cord-258536-qnn9hp8e	228	18	of	of	IN
cord-258536-qnn9hp8e	228	19	autophagy	autophagy	NN
cord-258536-qnn9hp8e	228	20	during	during	IN
cord-258536-qnn9hp8e	228	21	CoV	cov	NN
cord-258536-qnn9hp8e	228	22	infection	infection	NN
cord-258536-qnn9hp8e	228	23	remains	remain	VBZ
cord-258536-qnn9hp8e	228	24	to	to	TO
cord-258536-qnn9hp8e	228	25	be	be	VB
cord-258536-qnn9hp8e	228	26	explored	explore	VBN
cord-258536-qnn9hp8e	228	27	.	.	.
cord-258536-qnn9hp8e	229	1	The	the	DT
cord-258536-qnn9hp8e	229	2	investigation	investigation	NN
cord-258536-qnn9hp8e	229	3	of	of	IN
cord-258536-qnn9hp8e	229	4	the	the	DT
cord-258536-qnn9hp8e	229	5	potential	potential	JJ
cord-258536-qnn9hp8e	229	6	interplay	interplay	NN
cord-258536-qnn9hp8e	229	7	between	between	IN
cord-258536-qnn9hp8e	229	8	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	229	9	and	and	CC
cord-258536-qnn9hp8e	229	10	autophagy	autophagy	NN
cord-258536-qnn9hp8e	229	11	is	be	VBZ
cord-258536-qnn9hp8e	229	12	still	still	RB
cord-258536-qnn9hp8e	229	13	at	at	IN
cord-258536-qnn9hp8e	229	14	its	-PRON-	PRP$
cord-258536-qnn9hp8e	229	15	beginning	beginning	NN
cord-258536-qnn9hp8e	229	16	.	.	.
cord-258536-qnn9hp8e	230	1	Nonetheless	nonetheless	RB
cord-258536-qnn9hp8e	230	2	,	,	,
cord-258536-qnn9hp8e	230	3	it	-PRON-	PRP
cord-258536-qnn9hp8e	230	4	can	can	MD
cord-258536-qnn9hp8e	230	5	already	already	RB
cord-258536-qnn9hp8e	230	6	be	be	VB
cord-258536-qnn9hp8e	230	7	firmly	firmly	RB
cord-258536-qnn9hp8e	230	8	concluded	conclude	VBN
cord-258536-qnn9hp8e	230	9	that	that	IN
cord-258536-qnn9hp8e	230	10	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	230	11	infections	infection	NNS
cord-258536-qnn9hp8e	230	12	trigger	trigger	VBP
cord-258536-qnn9hp8e	230	13	autophagy	autophagy	NN
cord-258536-qnn9hp8e	230	14	in	in	IN
cord-258536-qnn9hp8e	230	15	host	host	NN
cord-258536-qnn9hp8e	230	16	cells	cell	NNS
cord-258536-qnn9hp8e	230	17	.	.	.
cord-258536-qnn9hp8e	231	1	Several	several	JJ
cord-258536-qnn9hp8e	231	2	viral	viral	JJ
cord-258536-qnn9hp8e	231	3	families	family	NNS
cord-258536-qnn9hp8e	231	4	and	and	CC
cord-258536-qnn9hp8e	231	5	virus	virus	NN
cord-258536-qnn9hp8e	231	6	species	specie	NNS
cord-258536-qnn9hp8e	231	7	such	such	JJ
cord-258536-qnn9hp8e	231	8	as	as	IN
cord-258536-qnn9hp8e	231	9	Torovirinae	Torovirinae	NNP
cord-258536-qnn9hp8e	231	10	,	,	,
cord-258536-qnn9hp8e	231	11	Mesoviridae	Mesoviridae	NNP
cord-258536-qnn9hp8e	231	12	,	,	,
cord-258536-qnn9hp8e	231	13	and	and	CC
cord-258536-qnn9hp8e	231	14	Roniviridae	Roniviridae	NNP
cord-258536-qnn9hp8e	231	15	,	,	,
cord-258536-qnn9hp8e	231	16	have	have	VBP
cord-258536-qnn9hp8e	231	17	yet	yet	RB
cord-258536-qnn9hp8e	231	18	to	to	TO
cord-258536-qnn9hp8e	231	19	be	be	VB
cord-258536-qnn9hp8e	231	20	investigated	investigate	VBN
cord-258536-qnn9hp8e	231	21	while	while	IN
cord-258536-qnn9hp8e	231	22	for	for	IN
cord-258536-qnn9hp8e	231	23	others	other	NNS
cord-258536-qnn9hp8e	231	24	,	,	,
cord-258536-qnn9hp8e	231	25	such	such	JJ
cord-258536-qnn9hp8e	231	26	as	as	IN
cord-258536-qnn9hp8e	231	27	PRSSV	PRSSV	NNP
cord-258536-qnn9hp8e	231	28	and	and	CC
cord-258536-qnn9hp8e	231	29	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	231	30	,	,	,
cord-258536-qnn9hp8e	231	31	opposite	opposite	JJ
cord-258536-qnn9hp8e	231	32	conclusions	conclusion	NNS
cord-258536-qnn9hp8e	231	33	have	have	VBP
cord-258536-qnn9hp8e	231	34	been	be	VBN
cord-258536-qnn9hp8e	231	35	reached	reach	VBN
cord-258536-qnn9hp8e	231	36	regarding	regard	VBG
cord-258536-qnn9hp8e	231	37	whether	whether	IN
cord-258536-qnn9hp8e	231	38	autophagy	autophagy	NN
cord-258536-qnn9hp8e	231	39	induction	induction	NN
cord-258536-qnn9hp8e	231	40	is	be	VBZ
cord-258536-qnn9hp8e	231	41	beneficial	beneficial	JJ
cord-258536-qnn9hp8e	231	42	or	or	CC
cord-258536-qnn9hp8e	231	43	detrimental	detrimental	JJ
cord-258536-qnn9hp8e	231	44	for	for	IN
cord-258536-qnn9hp8e	231	45	the	the	DT
cord-258536-qnn9hp8e	231	46	viral	viral	JJ
cord-258536-qnn9hp8e	231	47	life	life	NN
cord-258536-qnn9hp8e	231	48	cycle	cycle	NN
cord-258536-qnn9hp8e	231	49	.	.	.
cord-258536-qnn9hp8e	232	1	The	the	DT
cord-258536-qnn9hp8e	232	2	apparent	apparent	JJ
cord-258536-qnn9hp8e	232	3	contradictory	contradictory	JJ
cord-258536-qnn9hp8e	232	4	results	result	NNS
cord-258536-qnn9hp8e	232	5	could	could	MD
cord-258536-qnn9hp8e	232	6	be	be	VB
cord-258536-qnn9hp8e	232	7	due	due	JJ
cord-258536-qnn9hp8e	232	8	to	to	IN
cord-258536-qnn9hp8e	232	9	the	the	DT
cord-258536-qnn9hp8e	232	10	use	use	NN
cord-258536-qnn9hp8e	232	11	of	of	IN
cord-258536-qnn9hp8e	232	12	different	different	JJ
cord-258536-qnn9hp8e	232	13	cell	cell	NN
cord-258536-qnn9hp8e	232	14	lines	line	NNS
cord-258536-qnn9hp8e	232	15	and	and	CC
cord-258536-qnn9hp8e	232	16	tissues	tissue	NNS
cord-258536-qnn9hp8e	232	17	,	,	,
cord-258536-qnn9hp8e	232	18	and/or	and/or	CC
cord-258536-qnn9hp8e	232	19	virus	virus	NN
cord-258536-qnn9hp8e	232	20	strains	strain	NNS
cord-258536-qnn9hp8e	232	21	.	.	.
cord-258536-qnn9hp8e	233	1	Some	some	DT
cord-258536-qnn9hp8e	233	2	of	of	IN
cord-258536-qnn9hp8e	233	3	these	these	DT
cord-258536-qnn9hp8e	233	4	discrepancies	discrepancy	NNS
cord-258536-qnn9hp8e	233	5	could	could	MD
cord-258536-qnn9hp8e	233	6	also	also	RB
cord-258536-qnn9hp8e	233	7	be	be	VB
cord-258536-qnn9hp8e	233	8	due	due	JJ
cord-258536-qnn9hp8e	233	9	to	to	IN
cord-258536-qnn9hp8e	233	10	potential	potential	JJ
cord-258536-qnn9hp8e	233	11	noncanonical	noncanonical	JJ
cord-258536-qnn9hp8e	233	12	functions	function	NNS
cord-258536-qnn9hp8e	233	13	of	of	IN
cord-258536-qnn9hp8e	233	14	ATG	ATG	NNP
cord-258536-qnn9hp8e	233	15	proteins	protein	NNS
cord-258536-qnn9hp8e	233	16	as	as	IN
cord-258536-qnn9hp8e	233	17	was	be	VBD
cord-258536-qnn9hp8e	233	18	shown	show	VBN
cord-258536-qnn9hp8e	233	19	for	for	IN
cord-258536-qnn9hp8e	233	20	MHV	MHV	NNP
cord-258536-qnn9hp8e	233	21	.	.	.
cord-258536-qnn9hp8e	234	1	Further	further	JJ
cord-258536-qnn9hp8e	234	2	investigations	investigation	NNS
cord-258536-qnn9hp8e	234	3	are	be	VBP
cord-258536-qnn9hp8e	234	4	therefore	therefore	RB
cord-258536-qnn9hp8e	234	5	needed	need	VBN
cord-258536-qnn9hp8e	234	6	to	to	TO
cord-258536-qnn9hp8e	234	7	reconcile	reconcile	VB
cord-258536-qnn9hp8e	234	8	these	these	DT
cord-258536-qnn9hp8e	234	9	results	result	NNS
cord-258536-qnn9hp8e	234	10	.	.	.
cord-258536-qnn9hp8e	235	1	Another	another	DT
cord-258536-qnn9hp8e	235	2	drawback	drawback	NN
cord-258536-qnn9hp8e	235	3	of	of	IN
cord-258536-qnn9hp8e	235	4	several	several	JJ
cord-258536-qnn9hp8e	235	5	of	of	IN
cord-258536-qnn9hp8e	235	6	the	the	DT
cord-258536-qnn9hp8e	235	7	studies	study	NNS
cord-258536-qnn9hp8e	235	8	cited	cite	VBN
cord-258536-qnn9hp8e	235	9	in	in	IN
cord-258536-qnn9hp8e	235	10	this	this	DT
cord-258536-qnn9hp8e	235	11	review	review	NN
cord-258536-qnn9hp8e	235	12	is	be	VBZ
cord-258536-qnn9hp8e	235	13	the	the	DT
cord-258536-qnn9hp8e	235	14	extensive	extensive	JJ
cord-258536-qnn9hp8e	235	15	use	use	NN
cord-258536-qnn9hp8e	235	16	of	of	IN
cord-258536-qnn9hp8e	235	17	drugs	drug	NNS
cord-258536-qnn9hp8e	235	18	to	to	TO
cord-258536-qnn9hp8e	235	19	modulate	modulate	VB
cord-258536-qnn9hp8e	235	20	autophagy	autophagy	NN
cord-258536-qnn9hp8e	235	21	during	during	IN
cord-258536-qnn9hp8e	235	22	viral	viral	JJ
cord-258536-qnn9hp8e	235	23	infection	infection	NN
cord-258536-qnn9hp8e	235	24	.	.	.
cord-258536-qnn9hp8e	236	1	As	as	IN
cord-258536-qnn9hp8e	236	2	none	none	NN
cord-258536-qnn9hp8e	236	3	of	of	IN
cord-258536-qnn9hp8e	236	4	the	the	DT
cord-258536-qnn9hp8e	236	5	employed	employ	VBN
cord-258536-qnn9hp8e	236	6	compounds	compound	NNS
cord-258536-qnn9hp8e	236	7	inhibits	inhibit	VBZ
cord-258536-qnn9hp8e	236	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	236	9	specifically	specifically	RB
cord-258536-qnn9hp8e	236	10	,	,	,
cord-258536-qnn9hp8e	236	11	they	-PRON-	PRP
cord-258536-qnn9hp8e	236	12	can	can	MD
cord-258536-qnn9hp8e	236	13	have	have	VB
cord-258536-qnn9hp8e	236	14	adverse	adverse	JJ
cord-258536-qnn9hp8e	236	15	effects	effect	NNS
cord-258536-qnn9hp8e	236	16	on	on	IN
cord-258536-qnn9hp8e	236	17	cellular	cellular	JJ
cord-258536-qnn9hp8e	236	18	or	or	CC
cord-258536-qnn9hp8e	236	19	viral	viral	JJ
cord-258536-qnn9hp8e	236	20	biology	biology	NN
cord-258536-qnn9hp8e	236	21	,	,	,
cord-258536-qnn9hp8e	236	22	making	make	VBG
cord-258536-qnn9hp8e	236	23	the	the	DT
cord-258536-qnn9hp8e	236	24	interpretation	interpretation	NN
cord-258536-qnn9hp8e	236	25	of	of	IN
cord-258536-qnn9hp8e	236	26	the	the	DT
cord-258536-qnn9hp8e	236	27	results	result	NNS
cord-258536-qnn9hp8e	236	28	difficult	difficult	JJ
cord-258536-qnn9hp8e	236	29	.	.	.
cord-258536-qnn9hp8e	237	1	The	the	DT
cord-258536-qnn9hp8e	237	2	genetic	genetic	JJ
cord-258536-qnn9hp8e	237	3	ablation	ablation	NN
cord-258536-qnn9hp8e	237	4	of	of	IN
cord-258536-qnn9hp8e	237	5	ATG	ATG	NNP
cord-258536-qnn9hp8e	237	6	proteins	protein	NNS
cord-258536-qnn9hp8e	237	7	is	be	VBZ
cord-258536-qnn9hp8e	237	8	a	a	DT
cord-258536-qnn9hp8e	237	9	better	well	JJR
cord-258536-qnn9hp8e	237	10	option	option	NN
cord-258536-qnn9hp8e	237	11	but	but	CC
cord-258536-qnn9hp8e	237	12	it	-PRON-	PRP
cord-258536-qnn9hp8e	237	13	must	must	MD
cord-258536-qnn9hp8e	237	14	be	be	VB
cord-258536-qnn9hp8e	237	15	kept	keep	VBN
cord-258536-qnn9hp8e	237	16	in	in	IN
cord-258536-qnn9hp8e	237	17	mind	mind	NN
cord-258536-qnn9hp8e	237	18	that	that	IN
cord-258536-qnn9hp8e	237	19	these	these	DT
cord-258536-qnn9hp8e	237	20	factors	factor	NNS
cord-258536-qnn9hp8e	237	21	are	be	VBP
cord-258536-qnn9hp8e	237	22	also	also	RB
cord-258536-qnn9hp8e	237	23	part	part	NN
cord-258536-qnn9hp8e	237	24	of	of	IN
cord-258536-qnn9hp8e	237	25	other	other	JJ
cord-258536-qnn9hp8e	237	26	pathways	pathway	NNS
cord-258536-qnn9hp8e	237	27	[	[	-LRB-
cord-258536-qnn9hp8e	237	28	48	48	CD
cord-258536-qnn9hp8e	237	29	,	,	,
cord-258536-qnn9hp8e	237	30	94	94	CD
cord-258536-qnn9hp8e	237	31	]	]	-RRB-
cord-258536-qnn9hp8e	237	32	.	.	.
cord-258536-qnn9hp8e	238	1	As	as	IN
cord-258536-qnn9hp8e	238	2	a	a	DT
cord-258536-qnn9hp8e	238	3	result	result	NN
cord-258536-qnn9hp8e	238	4	,	,	,
cord-258536-qnn9hp8e	238	5	it	-PRON-	PRP
cord-258536-qnn9hp8e	238	6	is	be	VBZ
cord-258536-qnn9hp8e	238	7	crucial	crucial	JJ
cord-258536-qnn9hp8e	238	8	to	to	TO
cord-258536-qnn9hp8e	238	9	compare	compare	VB
cord-258536-qnn9hp8e	238	10	the	the	DT
cord-258536-qnn9hp8e	238	11	results	result	NNS
cord-258536-qnn9hp8e	238	12	obtained	obtain	VBN
cord-258536-qnn9hp8e	238	13	by	by	IN
cord-258536-qnn9hp8e	238	14	depleting	deplete	VBG
cord-258536-qnn9hp8e	238	15	more	more	JJR
cord-258536-qnn9hp8e	238	16	than	than	IN
cord-258536-qnn9hp8e	238	17	one	one	CD
cord-258536-qnn9hp8e	238	18	ATG	ATG	NNP
cord-258536-qnn9hp8e	238	19	protein	protein	NN
cord-258536-qnn9hp8e	238	20	.	.	.
cord-258536-qnn9hp8e	239	1	Moreover	moreover	RB
cord-258536-qnn9hp8e	239	2	,	,	,
cord-258536-qnn9hp8e	239	3	the	the	DT
cord-258536-qnn9hp8e	239	4	few	few	JJ
cord-258536-qnn9hp8e	239	5	studies	study	NNS
cord-258536-qnn9hp8e	239	6	that	that	WDT
cord-258536-qnn9hp8e	239	7	have	have	VBP
cord-258536-qnn9hp8e	239	8	depleted	deplete	VBN
cord-258536-qnn9hp8e	239	9	ATG	ATG	NNP
cord-258536-qnn9hp8e	239	10	proteins	protein	NNS
cord-258536-qnn9hp8e	239	11	have	have	VBP
cord-258536-qnn9hp8e	239	12	blocked	block	VBN
cord-258536-qnn9hp8e	239	13	the	the	DT
cord-258536-qnn9hp8e	239	14	initial	initial	JJ
cord-258536-qnn9hp8e	239	15	steps	step	NNS
cord-258536-qnn9hp8e	239	16	of	of	IN
cord-258536-qnn9hp8e	239	17	the	the	DT
cord-258536-qnn9hp8e	239	18	autophagic	autophagic	NNP
cord-258536-qnn9hp8e	239	19	pathway	pathway	NN
cord-258536-qnn9hp8e	239	20	(	(	-LRB-
cord-258536-qnn9hp8e	239	21	Figure	Figure	NNP
cord-258536-qnn9hp8e	239	22	3	3	CD
cord-258536-qnn9hp8e	239	23	and	and	CC
cord-258536-qnn9hp8e	239	24	Table	Table	NNP
cord-258536-qnn9hp8e	239	25	1	1	CD
cord-258536-qnn9hp8e	239	26	)	)	-RRB-
cord-258536-qnn9hp8e	239	27	without	without	IN
cord-258536-qnn9hp8e	239	28	analyzing	analyze	VBG
cord-258536-qnn9hp8e	239	29	the	the	DT
cord-258536-qnn9hp8e	239	30	steps	step	NNS
cord-258536-qnn9hp8e	239	31	following	follow	VBG
cord-258536-qnn9hp8e	239	32	the	the	DT
cord-258536-qnn9hp8e	239	33	completion	completion	NN
cord-258536-qnn9hp8e	239	34	of	of	IN
cord-258536-qnn9hp8e	239	35	an	an	DT
cord-258536-qnn9hp8e	239	36	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	239	37	.	.	.
cord-258536-qnn9hp8e	240	1	This	this	DT
cord-258536-qnn9hp8e	240	2	is	be	VBZ
cord-258536-qnn9hp8e	240	3	relevant	relevant	JJ
cord-258536-qnn9hp8e	240	4	since	since	IN
cord-258536-qnn9hp8e	240	5	some	some	DT
cord-258536-qnn9hp8e	240	6	viruses	virus	NNS
cord-258536-qnn9hp8e	240	7	such	such	JJ
cord-258536-qnn9hp8e	240	8	as	as	IN
cord-258536-qnn9hp8e	240	9	Influenza	Influenza	NNP
cord-258536-qnn9hp8e	240	10	A	A	NNP
cord-258536-qnn9hp8e	240	11	or	or	CC
cord-258536-qnn9hp8e	240	12	Epstein	Epstein	NNP
cord-258536-qnn9hp8e	240	13	-	-	HYPH
cord-258536-qnn9hp8e	240	14	Barr	Barr	NNP
cord-258536-qnn9hp8e	240	15	virus	virus	NN
cord-258536-qnn9hp8e	240	16	,	,	,
cord-258536-qnn9hp8e	240	17	have	have	VBP
cord-258536-qnn9hp8e	240	18	been	be	VBN
cord-258536-qnn9hp8e	240	19	shown	show	VBN
cord-258536-qnn9hp8e	240	20	to	to	TO
cord-258536-qnn9hp8e	240	21	manipulate	manipulate	VB
cord-258536-qnn9hp8e	240	22	this	this	DT
cord-258536-qnn9hp8e	240	23	part	part	NN
cord-258536-qnn9hp8e	240	24	of	of	IN
cord-258536-qnn9hp8e	240	25	the	the	DT
cord-258536-qnn9hp8e	240	26	pathway	pathway	NN
cord-258536-qnn9hp8e	240	27	and	and	CC
cord-258536-qnn9hp8e	240	28	therefore	therefore	RB
cord-258536-qnn9hp8e	240	29	it	-PRON-	PRP
cord-258536-qnn9hp8e	240	30	is	be	VBZ
cord-258536-qnn9hp8e	240	31	critical	critical	JJ
cord-258536-qnn9hp8e	240	32	to	to	TO
cord-258536-qnn9hp8e	240	33	investigate	investigate	VB
cord-258536-qnn9hp8e	240	34	whether	whether	IN
cord-258536-qnn9hp8e	240	35	it	-PRON-	PRP
cord-258536-qnn9hp8e	240	36	could	could	MD
cord-258536-qnn9hp8e	240	37	also	also	RB
cord-258536-qnn9hp8e	240	38	be	be	VB
cord-258536-qnn9hp8e	240	39	the	the	DT
cord-258536-qnn9hp8e	240	40	case	case	NN
cord-258536-qnn9hp8e	240	41	for	for	IN
cord-258536-qnn9hp8e	240	42	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	240	43	[	[	-LRB-
cord-258536-qnn9hp8e	240	44	95	95	CD
cord-258536-qnn9hp8e	240	45	,	,	,
cord-258536-qnn9hp8e	240	46	96	96	CD
cord-258536-qnn9hp8e	240	47	]	]	-RRB-
cord-258536-qnn9hp8e	240	48	.	.	.
cord-258536-qnn9hp8e	241	1	It	-PRON-	PRP
cord-258536-qnn9hp8e	241	2	also	also	RB
cord-258536-qnn9hp8e	241	3	remains	remain	VBZ
cord-258536-qnn9hp8e	241	4	unclear	unclear	JJ
cord-258536-qnn9hp8e	241	5	which	which	WDT
cord-258536-qnn9hp8e	241	6	step	step	NN
cord-258536-qnn9hp8e	241	7	of	of	IN
cord-258536-qnn9hp8e	241	8	the	the	DT
cord-258536-qnn9hp8e	241	9	virus	virus	NN
cord-258536-qnn9hp8e	241	10	life	life	NN
cord-258536-qnn9hp8e	241	11	cycle	cycle	NN
cord-258536-qnn9hp8e	241	12	is	be	VBZ
cord-258536-qnn9hp8e	241	13	impacted	impact	VBN
cord-258536-qnn9hp8e	241	14	,	,	,
cord-258536-qnn9hp8e	241	15	as	as	IN
cord-258536-qnn9hp8e	241	16	most	most	JJS
cord-258536-qnn9hp8e	241	17	studies	study	NNS
cord-258536-qnn9hp8e	241	18	relied	rely	VBD
cord-258536-qnn9hp8e	241	19	on	on	IN
cord-258536-qnn9hp8e	241	20	assays	assay	NNS
cord-258536-qnn9hp8e	241	21	quantifying	quantify	VBG
cord-258536-qnn9hp8e	241	22	general	general	JJ
cord-258536-qnn9hp8e	241	23	parameters	parameter	NNS
cord-258536-qnn9hp8e	241	24	such	such	JJ
cord-258536-qnn9hp8e	241	25	as	as	IN
cord-258536-qnn9hp8e	241	26	the	the	DT
cord-258536-qnn9hp8e	241	27	viral	viral	JJ
cord-258536-qnn9hp8e	241	28	protein	protein	NN
cord-258536-qnn9hp8e	241	29	levels	level	NNS
cord-258536-qnn9hp8e	241	30	,	,	,
cord-258536-qnn9hp8e	241	31	the	the	DT
cord-258536-qnn9hp8e	241	32	number	number	NN
cord-258536-qnn9hp8e	241	33	of	of	IN
cord-258536-qnn9hp8e	241	34	infected	infected	JJ
cord-258536-qnn9hp8e	241	35	cells	cell	NNS
cord-258536-qnn9hp8e	241	36	,	,	,
cord-258536-qnn9hp8e	241	37	and	and	CC
cord-258536-qnn9hp8e	241	38	/or	/or	.
cord-258536-qnn9hp8e	241	39	the	the	DT
cord-258536-qnn9hp8e	241	40	number	number	NN
cord-258536-qnn9hp8e	241	41	of	of	IN
cord-258536-qnn9hp8e	241	42	produced	produce	VBN
cord-258536-qnn9hp8e	241	43	infectious	infectious	JJ
cord-258536-qnn9hp8e	241	44	viral	viral	JJ
cord-258536-qnn9hp8e	241	45	particles	particle	NNS
cord-258536-qnn9hp8e	241	46	.	.	.
cord-258536-qnn9hp8e	242	1	Results	result	NNS
cord-258536-qnn9hp8e	242	2	that	that	WDT
cord-258536-qnn9hp8e	242	3	were	be	VBD
cord-258536-qnn9hp8e	242	4	obtained	obtain	VBN
cord-258536-qnn9hp8e	242	5	by	by	IN
cord-258536-qnn9hp8e	242	6	studying	study	VBG
cord-258536-qnn9hp8e	242	7	viruses	virus	NNS
cord-258536-qnn9hp8e	242	8	from	from	IN
cord-258536-qnn9hp8e	242	9	other	other	JJ
cord-258536-qnn9hp8e	242	10	orders	order	NNS
cord-258536-qnn9hp8e	242	11	have	have	VBP
cord-258536-qnn9hp8e	242	12	revealed	reveal	VBN
cord-258536-qnn9hp8e	242	13	that	that	IN
cord-258536-qnn9hp8e	242	14	autophagy	autophagy	NN
cord-258536-qnn9hp8e	242	15	and	and	CC
cord-258536-qnn9hp8e	242	16	ATG	ATG	NNP
cord-258536-qnn9hp8e	242	17	proteins	protein	NNS
cord-258536-qnn9hp8e	242	18	can	can	MD
cord-258536-qnn9hp8e	242	19	practically	practically	RB
cord-258536-qnn9hp8e	242	20	play	play	VB
cord-258536-qnn9hp8e	242	21	a	a	DT
cord-258536-qnn9hp8e	242	22	key	key	JJ
cord-258536-qnn9hp8e	242	23	role	role	NN
cord-258536-qnn9hp8e	242	24	in	in	IN
cord-258536-qnn9hp8e	242	25	every	every	DT
cord-258536-qnn9hp8e	242	26	step	step	NN
cord-258536-qnn9hp8e	242	27	of	of	IN
cord-258536-qnn9hp8e	242	28	a	a	DT
cord-258536-qnn9hp8e	242	29	virus	virus	NN
cord-258536-qnn9hp8e	242	30	life	life	NN
cord-258536-qnn9hp8e	242	31	cycle	cycle	NN
cord-258536-qnn9hp8e	242	32	,	,	,
cord-258536-qnn9hp8e	242	33	from	from	IN
cord-258536-qnn9hp8e	242	34	entry	entry	NN
cord-258536-qnn9hp8e	242	35	to	to	IN
cord-258536-qnn9hp8e	242	36	assembly	assembly	NN
cord-258536-qnn9hp8e	242	37	and	and	CC
cord-258536-qnn9hp8e	242	38	egression	egression	NN
cord-258536-qnn9hp8e	242	39	[	[	-LRB-
cord-258536-qnn9hp8e	242	40	97	97	CD
cord-258536-qnn9hp8e	242	41	]	]	-RRB-
cord-258536-qnn9hp8e	242	42	.	.	.
cord-258536-qnn9hp8e	243	1	While	while	IN
cord-258536-qnn9hp8e	243	2	it	-PRON-	PRP
cord-258536-qnn9hp8e	243	3	is	be	VBZ
cord-258536-qnn9hp8e	243	4	indisputable	indisputable	JJ
cord-258536-qnn9hp8e	243	5	that	that	IN
cord-258536-qnn9hp8e	243	6	large	large	JJ
cord-258536-qnn9hp8e	243	7	part	part	NN
cord-258536-qnn9hp8e	243	8	of	of	IN
cord-258536-qnn9hp8e	243	9	the	the	DT
cord-258536-qnn9hp8e	243	10	investigated	investigate	VBN
cord-258536-qnn9hp8e	243	11	Nidovirales	Nidovirales	NNP
cord-258536-qnn9hp8e	243	12	induces	induce	VBZ
cord-258536-qnn9hp8e	243	13	autophagy	autophagy	NN
cord-258536-qnn9hp8e	243	14	in	in	IN
cord-258536-qnn9hp8e	243	15	host	host	NN
cord-258536-qnn9hp8e	243	16	cells	cell	NNS
cord-258536-qnn9hp8e	243	17	,	,	,
cord-258536-qnn9hp8e	243	18	it	-PRON-	PRP
cord-258536-qnn9hp8e	243	19	still	still	RB
cord-258536-qnn9hp8e	243	20	remains	remain	VBZ
cord-258536-qnn9hp8e	243	21	unclear	unclear	JJ
cord-258536-qnn9hp8e	243	22	whether	whether	IN
cord-258536-qnn9hp8e	243	23	this	this	DT
cord-258536-qnn9hp8e	243	24	is	be	VBZ
cord-258536-qnn9hp8e	243	25	due	due	JJ
cord-258536-qnn9hp8e	243	26	to	to	IN
cord-258536-qnn9hp8e	243	27	a	a	DT
cord-258536-qnn9hp8e	243	28	subversion	subversion	NN
cord-258536-qnn9hp8e	243	29	of	of	IN
cord-258536-qnn9hp8e	243	30	autophagy	autophagy	NN
cord-258536-qnn9hp8e	243	31	by	by	IN
cord-258536-qnn9hp8e	243	32	the	the	DT
cord-258536-qnn9hp8e	243	33	virus	virus	NN
cord-258536-qnn9hp8e	243	34	or	or	CC
cord-258536-qnn9hp8e	243	35	whether	whether	IN
cord-258536-qnn9hp8e	243	36	it	-PRON-	PRP
cord-258536-qnn9hp8e	243	37	is	be	VBZ
cord-258536-qnn9hp8e	243	38	a	a	DT
cord-258536-qnn9hp8e	243	39	physiological	physiological	JJ
cord-258536-qnn9hp8e	243	40	response	response	NN
cord-258536-qnn9hp8e	243	41	to	to	IN
cord-258536-qnn9hp8e	243	42	the	the	DT
cord-258536-qnn9hp8e	243	43	cellular	cellular	JJ
cord-258536-qnn9hp8e	243	44	stress	stress	NN
cord-258536-qnn9hp8e	243	45	caused	cause	VBN
cord-258536-qnn9hp8e	243	46	by	by	IN
cord-258536-qnn9hp8e	243	47	either	either	CC
cord-258536-qnn9hp8e	243	48	the	the	DT
cord-258536-qnn9hp8e	243	49	infection	infection	NN
cord-258536-qnn9hp8e	243	50	or	or	CC
cord-258536-qnn9hp8e	243	51	the	the	DT
cord-258536-qnn9hp8e	243	52	transfection	transfection	NN
cord-258536-qnn9hp8e	243	53	of	of	IN
cord-258536-qnn9hp8e	243	54	single	single	JJ
cord-258536-qnn9hp8e	243	55	viral	viral	JJ
cord-258536-qnn9hp8e	243	56	proteins	protein	NNS
cord-258536-qnn9hp8e	243	57	.	.	.
cord-258536-qnn9hp8e	244	1	Future	future	JJ
cord-258536-qnn9hp8e	244	2	research	research	NN
cord-258536-qnn9hp8e	244	3	should	should	MD
cord-258536-qnn9hp8e	244	4	therefore	therefore	RB
cord-258536-qnn9hp8e	244	5	also	also	RB
cord-258536-qnn9hp8e	244	6	focus	focus	VB
cord-258536-qnn9hp8e	244	7	on	on	IN
cord-258536-qnn9hp8e	244	8	the	the	DT
cord-258536-qnn9hp8e	244	9	identification	identification	NN
cord-258536-qnn9hp8e	244	10	of	of	IN
cord-258536-qnn9hp8e	244	11	a	a	DT
cord-258536-qnn9hp8e	244	12	potential	potential	JJ
cord-258536-qnn9hp8e	244	13	direct	direct	JJ
cord-258536-qnn9hp8e	244	14	molecular	molecular	JJ
cord-258536-qnn9hp8e	244	15	link	link	NN
cord-258536-qnn9hp8e	244	16	between	between	IN
cord-258536-qnn9hp8e	244	17	viral	viral	JJ
cord-258536-qnn9hp8e	244	18	and	and	CC
cord-258536-qnn9hp8e	244	19	ATG	ATG	NNP
cord-258536-qnn9hp8e	244	20	proteins	protein	NNS
cord-258536-qnn9hp8e	244	21	.	.	.
cord-258536-qnn9hp8e	245	1	Such	such	JJ
cord-258536-qnn9hp8e	245	2	studies	study	NNS
cord-258536-qnn9hp8e	245	3	could	could	MD
cord-258536-qnn9hp8e	245	4	also	also	RB
cord-258536-qnn9hp8e	245	5	pave	pave	VB
cord-258536-qnn9hp8e	245	6	the	the	DT
cord-258536-qnn9hp8e	245	7	way	way	NN
cord-258536-qnn9hp8e	245	8	to	to	IN
cord-258536-qnn9hp8e	245	9	the	the	DT
cord-258536-qnn9hp8e	245	10	development	development	NN
cord-258536-qnn9hp8e	245	11	of	of	IN
cord-258536-qnn9hp8e	245	12	novel	novel	JJ
cord-258536-qnn9hp8e	245	13	antiviral	antiviral	JJ
cord-258536-qnn9hp8e	245	14	therapies	therapy	NNS
cord-258536-qnn9hp8e	245	15	targeting	target	VBG
cord-258536-qnn9hp8e	245	16	the	the	DT
cord-258536-qnn9hp8e	245	17	virus	virus	NN
cord-258536-qnn9hp8e	245	18	-	-	HYPH
cord-258536-qnn9hp8e	245	19	autophagy	autophagy	NN
cord-258536-qnn9hp8e	245	20	interaction	interaction	NN
cord-258536-qnn9hp8e	245	21	.	.	.
cord-258536-qnn9hp8e	246	1	Evolving	evolve	VBG
cord-258536-qnn9hp8e	246	2	the	the	DT
cord-258536-qnn9hp8e	246	3	largest	large	JJS
cord-258536-qnn9hp8e	246	4	RNA	RNA	NNP
cord-258536-qnn9hp8e	246	5	virus	virus	NN
cord-258536-qnn9hp8e	246	6	genome	genome	NN
cord-258536-qnn9hp8e	247	1	The	the	DT
cord-258536-qnn9hp8e	247	2	molecular	molecular	JJ
cord-258536-qnn9hp8e	247	3	biology	biology	NN
cord-258536-qnn9hp8e	247	4	of	of	IN
cord-258536-qnn9hp8e	247	5	coronaviruses	coronaviruse	NNS
cord-258536-qnn9hp8e	248	1	Virus	Virus	NNP
cord-258536-qnn9hp8e	248	2	Taxonomy	Taxonomy	NNP
cord-258536-qnn9hp8e	248	3	:	:	:
cord-258536-qnn9hp8e	249	1	Ninth	Ninth	NNP
cord-258536-qnn9hp8e	249	2	Report	Report	NNP
cord-258536-qnn9hp8e	249	3	of	of	IN
cord-258536-qnn9hp8e	249	4	the	the	DT
cord-258536-qnn9hp8e	249	5	International	International	NNP
cord-258536-qnn9hp8e	249	6	Committee	Committee	NNP
cord-258536-qnn9hp8e	249	7	on	on	IN
cord-258536-qnn9hp8e	249	8	Taxonomy	Taxonomy	NNP
cord-258536-qnn9hp8e	249	9	of	of	IN
cord-258536-qnn9hp8e	249	10	Viruses	Viruses	NNPS
cord-258536-qnn9hp8e	250	1	Nidovirus	Nidovirus	NNP
cord-258536-qnn9hp8e	250	2	transcription	transcription	NN
cord-258536-qnn9hp8e	250	3	:	:	:
cord-258536-qnn9hp8e	251	1	How	how	WRB
cord-258536-qnn9hp8e	251	2	to	to	TO
cord-258536-qnn9hp8e	251	3	make	make	VB
cord-258536-qnn9hp8e	251	4	sense	sense	NN
cord-258536-qnn9hp8e	251	5	The	the	DT
cord-258536-qnn9hp8e	251	6	Coronaviridae	Coronaviridae	NNP
cord-258536-qnn9hp8e	251	7	Retrospective	retrospective	JJ
cord-258536-qnn9hp8e	251	8	testing	testing	NN
cord-258536-qnn9hp8e	251	9	and	and	CC
cord-258536-qnn9hp8e	251	10	case	case	NN
cord-258536-qnn9hp8e	251	11	series	series	JJ
cord-258536-qnn9hp8e	251	12	study	study	NN
cord-258536-qnn9hp8e	251	13	of	of	IN
cord-258536-qnn9hp8e	251	14	porcine	porcine	JJ
cord-258536-qnn9hp8e	251	15	delta	delta	NN
cord-258536-qnn9hp8e	251	16	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	251	17	in	in	IN
cord-258536-qnn9hp8e	251	18	US	US	NNP
cord-258536-qnn9hp8e	251	19	swine	swine	NN
cord-258536-qnn9hp8e	251	20	herds	herd	NNS
cord-258536-qnn9hp8e	251	21	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	251	22	entry	entry	NN
cord-258536-qnn9hp8e	251	23	and	and	CC
cord-258536-qnn9hp8e	251	24	release	release	NN
cord-258536-qnn9hp8e	251	25	in	in	IN
cord-258536-qnn9hp8e	251	26	polarized	polarized	JJ
cord-258536-qnn9hp8e	251	27	epithelial	epithelial	JJ
cord-258536-qnn9hp8e	251	28	cells	cell	NNS
cord-258536-qnn9hp8e	251	29	:	:	:
cord-258536-qnn9hp8e	251	30	A	a	DT
cord-258536-qnn9hp8e	251	31	review	review	NN
cord-258536-qnn9hp8e	251	32	The	the	DT
cord-258536-qnn9hp8e	251	33	Genome	Genome	NNP
cord-258536-qnn9hp8e	251	34	Organization	Organization	NNP
cord-258536-qnn9hp8e	251	35	of	of	IN
cord-258536-qnn9hp8e	251	36	the	the	DT
cord-258536-qnn9hp8e	251	37	Nidovirales	Nidovirales	NNPS
cord-258536-qnn9hp8e	251	38	:	:	:
cord-258536-qnn9hp8e	251	39	Similarities	similarity	NNS
cord-258536-qnn9hp8e	251	40	and	and	CC
cord-258536-qnn9hp8e	251	41	Differences	Differences	NNPS
cord-258536-qnn9hp8e	251	42	Between	between	IN
cord-258536-qnn9hp8e	251	43	Arteri-	Arteri-	NNP
cord-258536-qnn9hp8e	251	44	,	,	,
cord-258536-qnn9hp8e	251	45	Toro-	Toro-	NNP
cord-258536-qnn9hp8e	251	46	,	,	,
cord-258536-qnn9hp8e	251	47	and	and	CC
cord-258536-qnn9hp8e	251	48	Coronaviruses	Coronaviruses	NNP
cord-258536-qnn9hp8e	251	49	Evolution	Evolution	NNP
cord-258536-qnn9hp8e	251	50	and	and	CC
cord-258536-qnn9hp8e	251	51	homologous	homologous	JJ
cord-258536-qnn9hp8e	251	52	recombination	recombination	NN
cord-258536-qnn9hp8e	251	53	of	of	IN
cord-258536-qnn9hp8e	251	54	the	the	DT
cord-258536-qnn9hp8e	251	55	hemagglutinin	hemagglutinin	NN
cord-258536-qnn9hp8e	251	56	-	-	HYPH
cord-258536-qnn9hp8e	251	57	esterase	esterase	NN
cord-258536-qnn9hp8e	251	58	gene	gene	NN
cord-258536-qnn9hp8e	251	59	sequences	sequence	NNS
cord-258536-qnn9hp8e	251	60	from	from	IN
cord-258536-qnn9hp8e	251	61	porcine	porcine	JJ
cord-258536-qnn9hp8e	251	62	torovirus	torovirus	NN
cord-258536-qnn9hp8e	252	1	Mesoniviruses	mesoniviruse	NNS
cord-258536-qnn9hp8e	252	2	are	be	VBP
cord-258536-qnn9hp8e	252	3	mosquito	mosquito	NN
cord-258536-qnn9hp8e	252	4	-	-	HYPH
cord-258536-qnn9hp8e	252	5	specific	specific	JJ
cord-258536-qnn9hp8e	252	6	viruses	virus	NNS
cord-258536-qnn9hp8e	252	7	with	with	IN
cord-258536-qnn9hp8e	252	8	extensive	extensive	JJ
cord-258536-qnn9hp8e	252	9	geographic	geographic	JJ
cord-258536-qnn9hp8e	252	10	distribution	distribution	NN
cord-258536-qnn9hp8e	252	11	and	and	CC
cord-258536-qnn9hp8e	252	12	host	host	NN
cord-258536-qnn9hp8e	252	13	range	range	NN
cord-258536-qnn9hp8e	252	14	Identification	identification	NN
cord-258536-qnn9hp8e	252	15	and	and	CC
cord-258536-qnn9hp8e	252	16	characterization	characterization	NN
cord-258536-qnn9hp8e	252	17	of	of	IN
cord-258536-qnn9hp8e	252	18	genetically	genetically	RB
cord-258536-qnn9hp8e	252	19	divergent	divergent	JJ
cord-258536-qnn9hp8e	252	20	members	member	NNS
cord-258536-qnn9hp8e	252	21	of	of	IN
cord-258536-qnn9hp8e	252	22	the	the	DT
cord-258536-qnn9hp8e	252	23	newly	newly	RB
cord-258536-qnn9hp8e	252	24	established	establish	VBN
cord-258536-qnn9hp8e	252	25	family	family	NN
cord-258536-qnn9hp8e	252	26	Mesoniviridae	Mesoniviridae	NNP
cord-258536-qnn9hp8e	252	27	An	an	DT
cord-258536-qnn9hp8e	252	28	insect	insect	NN
cord-258536-qnn9hp8e	252	29	nidovirus	nidovirus	NN
cord-258536-qnn9hp8e	252	30	emerging	emerge	VBG
cord-258536-qnn9hp8e	252	31	from	from	IN
cord-258536-qnn9hp8e	252	32	a	a	DT
cord-258536-qnn9hp8e	252	33	primary	primary	JJ
cord-258536-qnn9hp8e	252	34	tropical	tropical	JJ
cord-258536-qnn9hp8e	252	35	rainforest	rainforest	NN
cord-258536-qnn9hp8e	252	36	Complete	complete	JJ
cord-258536-qnn9hp8e	252	37	genome	genome	NN
cord-258536-qnn9hp8e	252	38	sequence	sequence	NN
cord-258536-qnn9hp8e	252	39	of	of	IN
cord-258536-qnn9hp8e	252	40	an	an	DT
cord-258536-qnn9hp8e	252	41	isolate	isolate	NN
cord-258536-qnn9hp8e	252	42	of	of	IN
cord-258536-qnn9hp8e	252	43	a	a	DT
cord-258536-qnn9hp8e	252	44	novel	novel	JJ
cord-258536-qnn9hp8e	252	45	genotype	genotype	NN
cord-258536-qnn9hp8e	252	46	of	of	IN
cord-258536-qnn9hp8e	252	47	yellow	yellow	JJ
cord-258536-qnn9hp8e	252	48	head	head	NN
cord-258536-qnn9hp8e	252	49	virus	virus	NN
cord-258536-qnn9hp8e	252	50	from	from	IN
cord-258536-qnn9hp8e	252	51	Fenneropenaeus	Fenneropenaeus	NNP
cord-258536-qnn9hp8e	252	52	chinensis	chinensis	NN
cord-258536-qnn9hp8e	252	53	indigenous	indigenous	JJ
cord-258536-qnn9hp8e	252	54	in	in	IN
cord-258536-qnn9hp8e	252	55	China	China	NNP
cord-258536-qnn9hp8e	252	56	Genetic	genetic	JJ
cord-258536-qnn9hp8e	252	57	engineering	engineering	NN
cord-258536-qnn9hp8e	252	58	alveolar	alveolar	NN
cord-258536-qnn9hp8e	252	59	macrophages	macrophage	NNS
cord-258536-qnn9hp8e	252	60	for	for	IN
cord-258536-qnn9hp8e	252	61	host	host	NN
cord-258536-qnn9hp8e	252	62	resistance	resistance	NN
cord-258536-qnn9hp8e	252	63	to	to	IN
cord-258536-qnn9hp8e	252	64	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	252	65	Assessment	Assessment	NNP
cord-258536-qnn9hp8e	252	66	of	of	IN
cord-258536-qnn9hp8e	252	67	the	the	DT
cord-258536-qnn9hp8e	252	68	economic	economic	JJ
cord-258536-qnn9hp8e	252	69	impact	impact	NN
cord-258536-qnn9hp8e	252	70	of	of	IN
cord-258536-qnn9hp8e	252	71	porcine	porcine	JJ
cord-258536-qnn9hp8e	252	72	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	252	73	and	and	CC
cord-258536-qnn9hp8e	252	74	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	252	75	syndrome	syndrome	NN
cord-258536-qnn9hp8e	252	76	on	on	IN
cord-258536-qnn9hp8e	252	77	swine	swine	NN
cord-258536-qnn9hp8e	252	78	production	production	NN
cord-258536-qnn9hp8e	252	79	in	in	IN
cord-258536-qnn9hp8e	252	80	the	the	DT
cord-258536-qnn9hp8e	252	81	United	United	NNP
cord-258536-qnn9hp8e	252	82	States	States	NNP
cord-258536-qnn9hp8e	252	83	Sequence	sequence	NN
cord-258536-qnn9hp8e	252	84	motifs	motif	NNS
cord-258536-qnn9hp8e	252	85	involved	involve	VBN
cord-258536-qnn9hp8e	252	86	in	in	IN
cord-258536-qnn9hp8e	252	87	the	the	DT
cord-258536-qnn9hp8e	252	88	regulation	regulation	NN
cord-258536-qnn9hp8e	252	89	of	of	IN
cord-258536-qnn9hp8e	252	90	discontinuous	discontinuous	JJ
cord-258536-qnn9hp8e	252	91	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	252	92	subgenomic	subgenomic	NNP
cord-258536-qnn9hp8e	252	93	RNA	RNA	NNP
cord-258536-qnn9hp8e	252	94	synthesis	synthesis	NN
cord-258536-qnn9hp8e	252	95	Dipeptidyl	Dipeptidyl	NNP
cord-258536-qnn9hp8e	252	96	peptidase	peptidase	NN
cord-258536-qnn9hp8e	252	97	4	4	CD
cord-258536-qnn9hp8e	252	98	is	be	VBZ
cord-258536-qnn9hp8e	252	99	a	a	DT
cord-258536-qnn9hp8e	252	100	functional	functional	JJ
cord-258536-qnn9hp8e	252	101	receptor	receptor	NN
cord-258536-qnn9hp8e	252	102	for	for	IN
cord-258536-qnn9hp8e	252	103	the	the	DT
cord-258536-qnn9hp8e	252	104	emerging	emerge	VBG
cord-258536-qnn9hp8e	252	105	human	human	JJ
cord-258536-qnn9hp8e	252	106	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	252	107	-	-	HYPH
cord-258536-qnn9hp8e	252	108	EMC	EMC	NNP
cord-258536-qnn9hp8e	252	109	Nidovirus	Nidovirus	NNP
cord-258536-qnn9hp8e	252	110	entry	entry	NN
cord-258536-qnn9hp8e	252	111	into	into	IN
cord-258536-qnn9hp8e	252	112	cells	cell	NNS
cord-258536-qnn9hp8e	252	113	Heterogeneity	heterogeneity	NN
cord-258536-qnn9hp8e	252	114	of	of	IN
cord-258536-qnn9hp8e	252	115	gene	gene	NN
cord-258536-qnn9hp8e	252	116	expression	expression	NN
cord-258536-qnn9hp8e	252	117	of	of	IN
cord-258536-qnn9hp8e	252	118	the	the	DT
cord-258536-qnn9hp8e	252	119	hemagglutinin	hemagglutinin	NN
cord-258536-qnn9hp8e	252	120	-	-	HYPH
cord-258536-qnn9hp8e	252	121	esterase	esterase	NN
cord-258536-qnn9hp8e	252	122	(	(	-LRB-
cord-258536-qnn9hp8e	252	123	HE	he	NN
cord-258536-qnn9hp8e	252	124	)	)	-RRB-
cord-258536-qnn9hp8e	252	125	protein	protein	NN
cord-258536-qnn9hp8e	252	126	of	of	IN
cord-258536-qnn9hp8e	252	127	murine	murine	JJ
cord-258536-qnn9hp8e	252	128	coronaviruses	coronaviruse	NNS
cord-258536-qnn9hp8e	253	1	Nidovirus	Nidovirus	NNP
cord-258536-qnn9hp8e	253	2	ribonucleases	ribonuclease	NNS
cord-258536-qnn9hp8e	253	3	:	:	:
cord-258536-qnn9hp8e	254	1	Structures	structure	NNS
cord-258536-qnn9hp8e	254	2	and	and	CC
cord-258536-qnn9hp8e	254	3	functions	function	NNS
cord-258536-qnn9hp8e	254	4	in	in	IN
cord-258536-qnn9hp8e	254	5	viral	viral	JJ
cord-258536-qnn9hp8e	254	6	replication	replication	NN
cord-258536-qnn9hp8e	254	7	Are	be	VBP
cord-258536-qnn9hp8e	254	8	nidoviruses	nidoviruse	NNS
cord-258536-qnn9hp8e	254	9	hijacking	hijack	VBG
cord-258536-qnn9hp8e	254	10	the	the	DT
cord-258536-qnn9hp8e	254	11	autophagy	autophagy	NN
cord-258536-qnn9hp8e	254	12	machinery	machinery	NN
cord-258536-qnn9hp8e	254	13	?	?	.
cord-258536-qnn9hp8e	255	1	The	the	DT
cord-258536-qnn9hp8e	255	2	Nidoviruses	Nidoviruses	NNPS
cord-258536-qnn9hp8e	255	3	:	:	:
cord-258536-qnn9hp8e	255	4	(	(	-LRB-
cord-258536-qnn9hp8e	255	5	Coronaviruses	Coronaviruses	NNP
cord-258536-qnn9hp8e	255	6	and	and	CC
cord-258536-qnn9hp8e	255	7	Arteriviruses	Arteriviruses	NNP
cord-258536-qnn9hp8e	255	8	)	)	-RRB-
cord-258536-qnn9hp8e	256	1	Autophagy	autophagy	UH
cord-258536-qnn9hp8e	256	2	:	:	:
cord-258536-qnn9hp8e	256	3	Renovation	renovation	NN
cord-258536-qnn9hp8e	256	4	of	of	IN
cord-258536-qnn9hp8e	256	5	cells	cell	NNS
cord-258536-qnn9hp8e	256	6	and	and	CC
cord-258536-qnn9hp8e	256	7	tissues	tissue	NNS
cord-258536-qnn9hp8e	256	8	Autophagy	Autophagy	NNS
cord-258536-qnn9hp8e	256	9	and	and	CC
cord-258536-qnn9hp8e	256	10	the	the	DT
cord-258536-qnn9hp8e	256	11	endo	endo	NN
cord-258536-qnn9hp8e	256	12	/	/	SYM
cord-258536-qnn9hp8e	256	13	exosomal	exosomal	VBD
cord-258536-qnn9hp8e	256	14	pathways	pathway	NNS
cord-258536-qnn9hp8e	256	15	in	in	IN
cord-258536-qnn9hp8e	256	16	health	health	NN
cord-258536-qnn9hp8e	256	17	and	and	CC
cord-258536-qnn9hp8e	256	18	disease	disease	NN
cord-258536-qnn9hp8e	256	19	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	256	20	-	-	HYPH
cord-258536-qnn9hp8e	256	21	from	from	IN
cord-258536-qnn9hp8e	256	22	molecular	molecular	JJ
cord-258536-qnn9hp8e	256	23	mechanisms	mechanism	NNS
cord-258536-qnn9hp8e	256	24	to	to	IN
cord-258536-qnn9hp8e	256	25	clinical	clinical	JJ
cord-258536-qnn9hp8e	256	26	relevance	relevance	NN
cord-258536-qnn9hp8e	257	1	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	257	2	in	in	IN
cord-258536-qnn9hp8e	257	3	leukocytes	leukocyte	NNS
cord-258536-qnn9hp8e	257	4	and	and	CC
cord-258536-qnn9hp8e	257	5	other	other	JJ
cord-258536-qnn9hp8e	257	6	cells	cell	NNS
cord-258536-qnn9hp8e	257	7	:	:	:
cord-258536-qnn9hp8e	257	8	Mechanisms	mechanism	NNS
cord-258536-qnn9hp8e	257	9	,	,	,
cord-258536-qnn9hp8e	257	10	subsystem	subsystem	NN
cord-258536-qnn9hp8e	257	11	organization	organization	NN
cord-258536-qnn9hp8e	257	12	,	,	,
cord-258536-qnn9hp8e	257	13	selectivity	selectivity	NN
cord-258536-qnn9hp8e	257	14	,	,	,
cord-258536-qnn9hp8e	257	15	and	and	CC
cord-258536-qnn9hp8e	257	16	links	link	NNS
cord-258536-qnn9hp8e	257	17	to	to	TO
cord-258536-qnn9hp8e	257	18	innate	innate	JJ
cord-258536-qnn9hp8e	257	19	immunity	immunity	NN
cord-258536-qnn9hp8e	257	20	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	257	21	function	function	NN
cord-258536-qnn9hp8e	257	22	and	and	CC
cord-258536-qnn9hp8e	257	23	its	-PRON-	PRP$
cord-258536-qnn9hp8e	257	24	relationship	relationship	NN
cord-258536-qnn9hp8e	257	25	to	to	IN
cord-258536-qnn9hp8e	257	26	pathology	pathology	NN
cord-258536-qnn9hp8e	257	27	,	,	,
cord-258536-qnn9hp8e	257	28	clinical	clinical	JJ
cord-258536-qnn9hp8e	257	29	applications	application	NNS
cord-258536-qnn9hp8e	257	30	,	,	,
cord-258536-qnn9hp8e	257	31	drug	drug	NN
cord-258536-qnn9hp8e	257	32	metabolism	metabolism	NN
cord-258536-qnn9hp8e	257	33	and	and	CC
cord-258536-qnn9hp8e	257	34	toxicity	toxicity	NN
cord-258536-qnn9hp8e	257	35	Advances	advance	NNS
cord-258536-qnn9hp8e	257	36	in	in	IN
cord-258536-qnn9hp8e	257	37	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	257	38	Regulatory	Regulatory	NNP
cord-258536-qnn9hp8e	257	39	Mechanisms	Mechanisms	NNPS
cord-258536-qnn9hp8e	257	40	.	.	.
cord-258536-qnn9hp8e	258	1	Cells	cell	NNS
cord-258536-qnn9hp8e	258	2	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	258	3	and	and	CC
cord-258536-qnn9hp8e	258	4	Mammalian	mammalian	JJ
cord-258536-qnn9hp8e	258	5	Viruses	virus	NNS
cord-258536-qnn9hp8e	258	6	:	:	:
cord-258536-qnn9hp8e	258	7	Roles	role	NNS
cord-258536-qnn9hp8e	258	8	in	in	IN
cord-258536-qnn9hp8e	258	9	Immune	Immune	NNP
cord-258536-qnn9hp8e	258	10	Response	response	NN
cord-258536-qnn9hp8e	258	11	,	,	,
cord-258536-qnn9hp8e	258	12	Viral	Viral	NNP
cord-258536-qnn9hp8e	258	13	Replication	Replication	NNP
cord-258536-qnn9hp8e	258	14	,	,	,
cord-258536-qnn9hp8e	258	15	and	and	CC
cord-258536-qnn9hp8e	259	1	Beyond	beyond	IN
cord-258536-qnn9hp8e	259	2	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	259	3	:	:	:
cord-258536-qnn9hp8e	259	4	From	from	IN
cord-258536-qnn9hp8e	259	5	phenomenology	phenomenology	NN
cord-258536-qnn9hp8e	259	6	to	to	IN
cord-258536-qnn9hp8e	259	7	molecular	molecular	JJ
cord-258536-qnn9hp8e	259	8	understanding	understanding	NN
cord-258536-qnn9hp8e	259	9	in	in	IN
cord-258536-qnn9hp8e	259	10	less	less	JJR
cord-258536-qnn9hp8e	259	11	than	than	IN
cord-258536-qnn9hp8e	259	12	a	a	DT
cord-258536-qnn9hp8e	259	13	decade	decade	NN
cord-258536-qnn9hp8e	259	14	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	259	15	as	as	IN
cord-258536-qnn9hp8e	259	16	a	a	DT
cord-258536-qnn9hp8e	259	17	regulated	regulated	JJ
cord-258536-qnn9hp8e	259	18	pathway	pathway	NN
cord-258536-qnn9hp8e	259	19	of	of	IN
cord-258536-qnn9hp8e	259	20	cellular	cellular	JJ
cord-258536-qnn9hp8e	259	21	degradation	degradation	NN
cord-258536-qnn9hp8e	259	22	Guidelines	guideline	NNS
cord-258536-qnn9hp8e	259	23	for	for	IN
cord-258536-qnn9hp8e	259	24	the	the	DT
cord-258536-qnn9hp8e	259	25	use	use	NN
cord-258536-qnn9hp8e	259	26	and	and	CC
cord-258536-qnn9hp8e	259	27	interpretation	interpretation	NN
cord-258536-qnn9hp8e	259	28	of	of	IN
cord-258536-qnn9hp8e	259	29	assays	assay	NNS
cord-258536-qnn9hp8e	259	30	for	for	IN
cord-258536-qnn9hp8e	259	31	monitoring	monitor	VBG
cord-258536-qnn9hp8e	259	32	autophagy	autophagy	NN
cord-258536-qnn9hp8e	260	1	The	the	DT
cord-258536-qnn9hp8e	260	2	autophagosome	autophagosome	NN
cord-258536-qnn9hp8e	260	3	is	be	VBZ
cord-258536-qnn9hp8e	260	4	overrated	overrated	JJ
cord-258536-qnn9hp8e	260	5	!	!	.
cord-258536-qnn9hp8e	261	1	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	261	2	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	261	3	:	:	:
cord-258536-qnn9hp8e	261	4	Molecular	molecular	JJ
cord-258536-qnn9hp8e	261	5	machinery	machinery	NN
cord-258536-qnn9hp8e	261	6	for	for	IN
cord-258536-qnn9hp8e	261	7	self	self	NN
cord-258536-qnn9hp8e	261	8	-	-	HYPH
cord-258536-qnn9hp8e	261	9	eating	eat	VBG
cord-258536-qnn9hp8e	261	10	Signaling	signal	VBG
cord-258536-qnn9hp8e	261	11	the	the	DT
cord-258536-qnn9hp8e	261	12	beginning	beginning	NN
cord-258536-qnn9hp8e	261	13	from	from	IN
cord-258536-qnn9hp8e	261	14	the	the	DT
cord-258536-qnn9hp8e	261	15	end	end	NN
cord-258536-qnn9hp8e	262	1	The	the	DT
cord-258536-qnn9hp8e	262	2	ULK1	ULK1	NNP
cord-258536-qnn9hp8e	262	3	complex	complex	NN
cord-258536-qnn9hp8e	262	4	:	:	:
cord-258536-qnn9hp8e	263	1	Sensing	sense	VBG
cord-258536-qnn9hp8e	263	2	nutrient	nutrient	NN
cord-258536-qnn9hp8e	263	3	signals	signal	NNS
cord-258536-qnn9hp8e	263	4	for	for	IN
cord-258536-qnn9hp8e	263	5	autophagy	autophagy	NN
cord-258536-qnn9hp8e	263	6	activation	activation	NN
cord-258536-qnn9hp8e	264	1	Autophagosome	Autophagosome	NNP
cord-258536-qnn9hp8e	264	2	formation-	formation-	NN
cord-258536-qnn9hp8e	265	1	The	the	DT
cord-258536-qnn9hp8e	265	2	role	role	NN
cord-258536-qnn9hp8e	265	3	of	of	IN
cord-258536-qnn9hp8e	265	4	ULK1	ULK1	NNP
cord-258536-qnn9hp8e	265	5	and	and	CC
cord-258536-qnn9hp8e	265	6	Beclin1-PI3KC3	beclin1-pi3kc3	NN
cord-258536-qnn9hp8e	265	7	complexes	complex	NNS
cord-258536-qnn9hp8e	265	8	in	in	IN
cord-258536-qnn9hp8e	265	9	setting	set	VBG
cord-258536-qnn9hp8e	265	10	the	the	DT
cord-258536-qnn9hp8e	265	11	stage	stage	NN
cord-258536-qnn9hp8e	266	1	Autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	266	2	formation	formation	NN
cord-258536-qnn9hp8e	266	3	from	from	IN
cord-258536-qnn9hp8e	266	4	membrane	membrane	NN
cord-258536-qnn9hp8e	266	5	compartments	compartment	NNS
cord-258536-qnn9hp8e	266	6	enriched	enrich	VBN
cord-258536-qnn9hp8e	266	7	in	in	IN
cord-258536-qnn9hp8e	266	8	phosphatidylinositol	phosphatidylinositol	JJ
cord-258536-qnn9hp8e	266	9	3-phosphate	3-phosphate	CD
cord-258536-qnn9hp8e	266	10	and	and	CC
cord-258536-qnn9hp8e	266	11	dynamically	dynamically	RB
cord-258536-qnn9hp8e	266	12	connected	connect	VBN
cord-258536-qnn9hp8e	266	13	to	to	IN
cord-258536-qnn9hp8e	266	14	the	the	DT
cord-258536-qnn9hp8e	266	15	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	266	16	reticulum	reticulum	NN
cord-258536-qnn9hp8e	267	1	The	the	DT
cord-258536-qnn9hp8e	267	2	puzzling	puzzling	JJ
cord-258536-qnn9hp8e	267	3	origin	origin	NN
cord-258536-qnn9hp8e	267	4	of	of	IN
cord-258536-qnn9hp8e	267	5	the	the	DT
cord-258536-qnn9hp8e	267	6	autophagosomal	autophagosomal	NNP
cord-258536-qnn9hp8e	267	7	membrane	membrane	NN
cord-258536-qnn9hp8e	267	8	Dynamic	Dynamic	NNP
cord-258536-qnn9hp8e	267	9	association	association	NNP
cord-258536-qnn9hp8e	267	10	of	of	IN
cord-258536-qnn9hp8e	267	11	the	the	DT
cord-258536-qnn9hp8e	267	12	ULK1	ULK1	NNP
cord-258536-qnn9hp8e	267	13	complex	complex	NN
cord-258536-qnn9hp8e	267	14	with	with	IN
cord-258536-qnn9hp8e	267	15	omegasomes	omegasome	NNS
cord-258536-qnn9hp8e	267	16	during	during	IN
cord-258536-qnn9hp8e	267	17	autophagy	autophagy	NN
cord-258536-qnn9hp8e	267	18	induction	induction	NN
cord-258536-qnn9hp8e	268	1	Temporal	temporal	JJ
cord-258536-qnn9hp8e	268	2	analysis	analysis	NN
cord-258536-qnn9hp8e	268	3	of	of	IN
cord-258536-qnn9hp8e	268	4	recruitment	recruitment	NN
cord-258536-qnn9hp8e	268	5	of	of	IN
cord-258536-qnn9hp8e	268	6	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	268	7	ATG	ATG	NNP
cord-258536-qnn9hp8e	268	8	proteins	protein	NNS
cord-258536-qnn9hp8e	268	9	to	to	IN
cord-258536-qnn9hp8e	268	10	the	the	DT
cord-258536-qnn9hp8e	268	11	autophagosome	autophagosome	NNP
cord-258536-qnn9hp8e	268	12	formation	formation	NN
cord-258536-qnn9hp8e	268	13	site	site	NN
cord-258536-qnn9hp8e	268	14	Mammalian	Mammalian	NNP
cord-258536-qnn9hp8e	268	15	Atg18	Atg18	NNP
cord-258536-qnn9hp8e	269	1	(	(	-LRB-
cord-258536-qnn9hp8e	269	2	WIPI2	WIPI2	NNP
cord-258536-qnn9hp8e	269	3	)	)	-RRB-
cord-258536-qnn9hp8e	269	4	localizes	localize	VBZ
cord-258536-qnn9hp8e	269	5	to	to	IN
cord-258536-qnn9hp8e	269	6	omegasome	omegasome	NN
cord-258536-qnn9hp8e	269	7	-	-	HYPH
cord-258536-qnn9hp8e	269	8	anchored	anchor	VBN
cord-258536-qnn9hp8e	269	9	phagophores	phagophore	NNS
cord-258536-qnn9hp8e	269	10	and	and	CC
cord-258536-qnn9hp8e	269	11	positively	positively	RB
cord-258536-qnn9hp8e	269	12	regulates	regulate	VBZ
cord-258536-qnn9hp8e	269	13	LC3	lc3	JJ
cord-258536-qnn9hp8e	269	14	lipidation	lipidation	NN
cord-258536-qnn9hp8e	269	15	Dynamic	dynamic	JJ
cord-258536-qnn9hp8e	269	16	and	and	CC
cord-258536-qnn9hp8e	269	17	transient	transient	JJ
cord-258536-qnn9hp8e	269	18	interactions	interaction	NNS
cord-258536-qnn9hp8e	269	19	of	of	IN
cord-258536-qnn9hp8e	269	20	Atg9	Atg9	NNP
cord-258536-qnn9hp8e	269	21	with	with	IN
cord-258536-qnn9hp8e	269	22	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	269	23	,	,	,
cord-258536-qnn9hp8e	269	24	but	but	CC
cord-258536-qnn9hp8e	269	25	not	not	RB
cord-258536-qnn9hp8e	269	26	membrane	membrane	NN
cord-258536-qnn9hp8e	269	27	integration	integration	NN
cord-258536-qnn9hp8e	269	28	,	,	,
cord-258536-qnn9hp8e	269	29	are	be	VBP
cord-258536-qnn9hp8e	269	30	required	require	VBN
cord-258536-qnn9hp8e	269	31	for	for	IN
cord-258536-qnn9hp8e	269	32	autophagy	autophagy	NN
cord-258536-qnn9hp8e	269	33	Mammalian	mammalian	JJ
cord-258536-qnn9hp8e	269	34	autophagy	autophagy	NN
cord-258536-qnn9hp8e	269	35	:	:	:
cord-258536-qnn9hp8e	269	36	Core	core	JJ
cord-258536-qnn9hp8e	269	37	molecular	molecular	JJ
cord-258536-qnn9hp8e	269	38	machinery	machinery	NN
cord-258536-qnn9hp8e	269	39	and	and	CC
cord-258536-qnn9hp8e	269	40	signaling	signal	VBG
cord-258536-qnn9hp8e	269	41	regulation	regulation	NN
cord-258536-qnn9hp8e	269	42	Hidden	hide	VBN
cord-258536-qnn9hp8e	269	43	behind	behind	IN
cord-258536-qnn9hp8e	269	44	autophagy	autophagy	NN
cord-258536-qnn9hp8e	269	45	:	:	:
cord-258536-qnn9hp8e	270	1	The	the	DT
cord-258536-qnn9hp8e	270	2	unconventional	unconventional	JJ
cord-258536-qnn9hp8e	270	3	roles	role	NNS
cord-258536-qnn9hp8e	270	4	of	of	IN
cord-258536-qnn9hp8e	270	5	ATG	ATG	NNP
cord-258536-qnn9hp8e	270	6	proteins	protein	NNS
cord-258536-qnn9hp8e	270	7	Non	Non	NNP
cord-258536-qnn9hp8e	270	8	-	-	JJ
cord-258536-qnn9hp8e	270	9	autophagic	autophagic	JJ
cord-258536-qnn9hp8e	270	10	roles	role	NNS
cord-258536-qnn9hp8e	270	11	of	of	IN
cord-258536-qnn9hp8e	270	12	autophagy	autophagy	NN
cord-258536-qnn9hp8e	270	13	-	-	HYPH
cord-258536-qnn9hp8e	270	14	related	relate	VBN
cord-258536-qnn9hp8e	270	15	proteins	protein	NNS
cord-258536-qnn9hp8e	270	16	ATG	ATG	NNP
cord-258536-qnn9hp8e	270	17	proteins	protein	NNS
cord-258536-qnn9hp8e	270	18	:	:	:
cord-258536-qnn9hp8e	270	19	Are	be	VBP
cord-258536-qnn9hp8e	270	20	we	-PRON-	PRP
cord-258536-qnn9hp8e	270	21	always	always	RB
cord-258536-qnn9hp8e	270	22	looking	look	VBG
cord-258536-qnn9hp8e	270	23	at	at	IN
cord-258536-qnn9hp8e	270	24	autophagy	autophagy	NN
cord-258536-qnn9hp8e	270	25	?	?	.
cord-258536-qnn9hp8e	271	1	Autophagy	Autophagy	NNS
cord-258536-qnn9hp8e	271	2	Using	use	VBG
cord-258536-qnn9hp8e	271	3	microbes	microbe	NNS
cord-258536-qnn9hp8e	271	4	as	as	IN
cord-258536-qnn9hp8e	271	5	a	a	DT
cord-258536-qnn9hp8e	271	6	key	key	JJ
cord-258536-qnn9hp8e	271	7	tool	tool	NN
cord-258536-qnn9hp8e	271	8	to	to	TO
cord-258536-qnn9hp8e	271	9	unravel	unravel	VB
cord-258536-qnn9hp8e	271	10	the	the	DT
cord-258536-qnn9hp8e	271	11	mechanism	mechanism	NN
cord-258536-qnn9hp8e	271	12	of	of	IN
cord-258536-qnn9hp8e	271	13	autophagy	autophagy	NN
cord-258536-qnn9hp8e	271	14	and	and	CC
cord-258536-qnn9hp8e	271	15	the	the	DT
cord-258536-qnn9hp8e	271	16	functions	function	NNS
cord-258536-qnn9hp8e	271	17	of	of	IN
cord-258536-qnn9hp8e	271	18	the	the	DT
cord-258536-qnn9hp8e	271	19	ATG	ATG	NNP
cord-258536-qnn9hp8e	271	20	proteins	protein	NNS
cord-258536-qnn9hp8e	271	21	Unique	unique	JJ
cord-258536-qnn9hp8e	271	22	role	role	NN
cord-258536-qnn9hp8e	271	23	for	for	IN
cord-258536-qnn9hp8e	271	24	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	271	25	in	in	IN
cord-258536-qnn9hp8e	271	26	neutrophil	neutrophil	NN
cord-258536-qnn9hp8e	271	27	-	-	HYPH
cord-258536-qnn9hp8e	271	28	mediated	mediate	VBN
cord-258536-qnn9hp8e	271	29	immunopathology	immunopathology	NN
cord-258536-qnn9hp8e	271	30	during	during	IN
cord-258536-qnn9hp8e	271	31	M.	M.	NNP
cord-258536-qnn9hp8e	271	32	tuberculosis	tuberculosis	NN
cord-258536-qnn9hp8e	271	33	infection	infection	NN
cord-258536-qnn9hp8e	272	1	An	an	DT
cord-258536-qnn9hp8e	272	2	siRNA	siRNA	NNP
cord-258536-qnn9hp8e	272	3	screen	screen	NN
cord-258536-qnn9hp8e	272	4	for	for	IN
cord-258536-qnn9hp8e	272	5	ATG	ATG	NNP
cord-258536-qnn9hp8e	272	6	protein	protein	NN
cord-258536-qnn9hp8e	272	7	depletion	depletion	NN
cord-258536-qnn9hp8e	272	8	reveals	reveal	VBZ
cord-258536-qnn9hp8e	272	9	the	the	DT
cord-258536-qnn9hp8e	272	10	extent	extent	NN
cord-258536-qnn9hp8e	272	11	of	of	IN
cord-258536-qnn9hp8e	272	12	the	the	DT
cord-258536-qnn9hp8e	272	13	unconventional	unconventional	JJ
cord-258536-qnn9hp8e	272	14	functions	function	NNS
cord-258536-qnn9hp8e	272	15	of	of	IN
cord-258536-qnn9hp8e	272	16	the	the	DT
cord-258536-qnn9hp8e	272	17	autophagy	autophagy	NN
cord-258536-qnn9hp8e	272	18	proteome	proteome	NN
cord-258536-qnn9hp8e	272	19	in	in	IN
cord-258536-qnn9hp8e	272	20	virus	virus	NN
cord-258536-qnn9hp8e	272	21	replication	replication	NN
cord-258536-qnn9hp8e	272	22	Segregation	segregation	NN
cord-258536-qnn9hp8e	272	23	and	and	CC
cord-258536-qnn9hp8e	272	24	rapid	rapid	JJ
cord-258536-qnn9hp8e	272	25	turnover	turnover	NN
cord-258536-qnn9hp8e	272	26	of	of	IN
cord-258536-qnn9hp8e	272	27	EDEM1	edem1	NN
cord-258536-qnn9hp8e	272	28	by	by	IN
cord-258536-qnn9hp8e	272	29	an	an	DT
cord-258536-qnn9hp8e	272	30	autophagy	autophagy	NN
cord-258536-qnn9hp8e	272	31	-	-	HYPH
cord-258536-qnn9hp8e	272	32	like	like	JJ
cord-258536-qnn9hp8e	272	33	mechanism	mechanism	NN
cord-258536-qnn9hp8e	272	34	modulates	modulate	VBZ
cord-258536-qnn9hp8e	272	35	standard	standard	JJ
cord-258536-qnn9hp8e	272	36	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	272	37	and	and	CC
cord-258536-qnn9hp8e	272	38	folding	folding	NN
cord-258536-qnn9hp8e	272	39	activities	activity	NNS
cord-258536-qnn9hp8e	273	1	Basal	basal	NN
cord-258536-qnn9hp8e	273	2	autophagy	autophagy	NN
cord-258536-qnn9hp8e	273	3	is	be	VBZ
cord-258536-qnn9hp8e	273	4	involved	involve	VBN
cord-258536-qnn9hp8e	273	5	in	in	IN
cord-258536-qnn9hp8e	273	6	the	the	DT
cord-258536-qnn9hp8e	273	7	degradation	degradation	NN
cord-258536-qnn9hp8e	273	8	of	of	IN
cord-258536-qnn9hp8e	273	9	the	the	DT
cord-258536-qnn9hp8e	273	10	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	273	11	component	component	NN
cord-258536-qnn9hp8e	273	12	EDEM1	edem1	XX
cord-258536-qnn9hp8e	274	1	EDEM1	EDEM1	NNP
cord-258536-qnn9hp8e	274	2	reveals	reveal	VBZ
cord-258536-qnn9hp8e	274	3	a	a	DT
cord-258536-qnn9hp8e	274	4	quality	quality	NN
cord-258536-qnn9hp8e	274	5	control	control	NN
cord-258536-qnn9hp8e	274	6	vesicular	vesicular	JJ
cord-258536-qnn9hp8e	274	7	transport	transport	NN
cord-258536-qnn9hp8e	274	8	pathway	pathway	NN
cord-258536-qnn9hp8e	274	9	out	out	IN
cord-258536-qnn9hp8e	274	10	of	of	IN
cord-258536-qnn9hp8e	274	11	the	the	DT
cord-258536-qnn9hp8e	274	12	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	274	13	reticulum	reticulum	NN
cord-258536-qnn9hp8e	274	14	not	not	RB
cord-258536-qnn9hp8e	274	15	involving	involve	VBG
cord-258536-qnn9hp8e	274	16	the	the	DT
cord-258536-qnn9hp8e	274	17	COPII	COPII	NNP
cord-258536-qnn9hp8e	274	18	exit	exit	NN
cord-258536-qnn9hp8e	274	19	sites	site	NNS
cord-258536-qnn9hp8e	275	1	Induction	induction	NN
cord-258536-qnn9hp8e	275	2	of	of	IN
cord-258536-qnn9hp8e	275	3	autophagy	autophagy	NN
cord-258536-qnn9hp8e	275	4	enhances	enhance	VBZ
cord-258536-qnn9hp8e	275	5	porcine	porcine	JJ
cord-258536-qnn9hp8e	275	6	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	275	7	and	and	CC
cord-258536-qnn9hp8e	275	8	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	275	9	syndrome	syndrome	NN
cord-258536-qnn9hp8e	275	10	virus	virus	NN
cord-258536-qnn9hp8e	275	11	replication	replication	NN
cord-258536-qnn9hp8e	275	12	Role	role	NN
cord-258536-qnn9hp8e	275	13	of	of	IN
cord-258536-qnn9hp8e	275	14	phosphatidylinositol-3-kinase	phosphatidylinositol-3-kinase	NNP
cord-258536-qnn9hp8e	275	15	(	(	-LRB-
cord-258536-qnn9hp8e	275	16	PI3	PI3	NNP
cord-258536-qnn9hp8e	275	17	K	K	NNP
cord-258536-qnn9hp8e	275	18	)	)	-RRB-
cord-258536-qnn9hp8e	275	19	and	and	CC
cord-258536-qnn9hp8e	275	20	the	the	DT
cord-258536-qnn9hp8e	275	21	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	275	22	target	target	NN
cord-258536-qnn9hp8e	275	23	of	of	IN
cord-258536-qnn9hp8e	275	24	rapamycin	rapamycin	NNP
cord-258536-qnn9hp8e	275	25	(	(	-LRB-
cord-258536-qnn9hp8e	275	26	mTOR	mTOR	NNP
cord-258536-qnn9hp8e	275	27	)	)	-RRB-
cord-258536-qnn9hp8e	275	28	signalling	signal	VBG
cord-258536-qnn9hp8e	275	29	pathways	pathway	NNS
cord-258536-qnn9hp8e	275	30	in	in	IN
cord-258536-qnn9hp8e	275	31	porcine	porcine	JJ
cord-258536-qnn9hp8e	275	32	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	275	33	and	and	CC
cord-258536-qnn9hp8e	275	34	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	275	35	syndrome	syndrome	NN
cord-258536-qnn9hp8e	275	36	virus	virus	NN
cord-258536-qnn9hp8e	275	37	(	(	-LRB-
cord-258536-qnn9hp8e	275	38	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	275	39	)	)	-RRB-
cord-258536-qnn9hp8e	275	40	replication	replication	NN
cord-258536-qnn9hp8e	276	1	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	276	2	sustains	sustain	VBZ
cord-258536-qnn9hp8e	276	3	the	the	DT
cord-258536-qnn9hp8e	276	4	replication	replication	NN
cord-258536-qnn9hp8e	276	5	of	of	IN
cord-258536-qnn9hp8e	276	6	porcine	porcine	JJ
cord-258536-qnn9hp8e	276	7	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	276	8	and	and	CC
cord-258536-qnn9hp8e	276	9	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	276	10	virus	virus	NN
cord-258536-qnn9hp8e	276	11	in	in	IN
cord-258536-qnn9hp8e	276	12	host	host	NN
cord-258536-qnn9hp8e	276	13	cells	cell	NNS
cord-258536-qnn9hp8e	277	1	Porcine	porcine	JJ
cord-258536-qnn9hp8e	277	2	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	277	3	and	and	CC
cord-258536-qnn9hp8e	277	4	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	277	5	syndrome	syndrome	NN
cord-258536-qnn9hp8e	277	6	virus	virus	NN
cord-258536-qnn9hp8e	277	7	induces	induce	VBZ
cord-258536-qnn9hp8e	277	8	autophagy	autophagy	NN
cord-258536-qnn9hp8e	277	9	to	to	TO
cord-258536-qnn9hp8e	277	10	promote	promote	VB
cord-258536-qnn9hp8e	277	11	virus	virus	NN
cord-258536-qnn9hp8e	277	12	replication	replication	NN
cord-258536-qnn9hp8e	277	13	Highly	highly	RB
cord-258536-qnn9hp8e	277	14	Pathogenic	pathogenic	JJ
cord-258536-qnn9hp8e	277	15	Porcine	porcine	JJ
cord-258536-qnn9hp8e	277	16	Reproductive	reproductive	JJ
cord-258536-qnn9hp8e	277	17	and	and	CC
cord-258536-qnn9hp8e	277	18	Respiratory	respiratory	JJ
cord-258536-qnn9hp8e	277	19	Syndrome	Syndrome	NNP
cord-258536-qnn9hp8e	277	20	Virus	virus	NN
cord-258536-qnn9hp8e	277	21	Infection	infection	NN
cord-258536-qnn9hp8e	277	22	Induced	induce	VBD
cord-258536-qnn9hp8e	277	23	Apoptosis	Apoptosis	NNP
cord-258536-qnn9hp8e	277	24	and	and	CC
cord-258536-qnn9hp8e	277	25	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	277	26	in	in	IN
cord-258536-qnn9hp8e	277	27	Thymi	Thymi	NNP
cord-258536-qnn9hp8e	277	28	of	of	IN
cord-258536-qnn9hp8e	277	29	Infected	infected	JJ
cord-258536-qnn9hp8e	277	30	Piglets	piglet	NNS
cord-258536-qnn9hp8e	277	31	Interplay	Interplay	NNP
cord-258536-qnn9hp8e	277	32	of	of	IN
cord-258536-qnn9hp8e	277	33	autophagy	autophagy	NN
cord-258536-qnn9hp8e	277	34	and	and	CC
cord-258536-qnn9hp8e	277	35	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	277	36	during	during	IN
cord-258536-qnn9hp8e	277	37	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	277	38	infection	infection	NN
cord-258536-qnn9hp8e	277	39	of	of	IN
cord-258536-qnn9hp8e	277	40	Marc145	Marc145	NNP
cord-258536-qnn9hp8e	277	41	cell	cell	NN
cord-258536-qnn9hp8e	277	42	Open	Open	NNP
cord-258536-qnn9hp8e	277	43	reading	reading	NN
cord-258536-qnn9hp8e	277	44	frame	frame	NN
cord-258536-qnn9hp8e	277	45	1a	1a	CD
cord-258536-qnn9hp8e	277	46	-	-	HYPH
cord-258536-qnn9hp8e	277	47	encoded	encode	VBN
cord-258536-qnn9hp8e	277	48	subunits	subunit	NNS
cord-258536-qnn9hp8e	277	49	of	of	IN
cord-258536-qnn9hp8e	277	50	the	the	DT
cord-258536-qnn9hp8e	277	51	arterivirus	arterivirus	NNP
cord-258536-qnn9hp8e	277	52	replicase	replicase	NNP
cord-258536-qnn9hp8e	277	53	induce	induce	VB
cord-258536-qnn9hp8e	277	54	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	277	55	reticulum	reticulum	NN
cord-258536-qnn9hp8e	277	56	-	-	HYPH
cord-258536-qnn9hp8e	277	57	derived	derive	VBN
cord-258536-qnn9hp8e	277	58	double	double	JJ
cord-258536-qnn9hp8e	277	59	-	-	HYPH
cord-258536-qnn9hp8e	277	60	membrane	membrane	NN
cord-258536-qnn9hp8e	277	61	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	277	62	which	which	WDT
cord-258536-qnn9hp8e	277	63	carry	carry	VBP
cord-258536-qnn9hp8e	277	64	the	the	DT
cord-258536-qnn9hp8e	277	65	viral	viral	JJ
cord-258536-qnn9hp8e	277	66	replication	replication	NN
cord-258536-qnn9hp8e	277	67	complex	complex	JJ
cord-258536-qnn9hp8e	277	68	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	277	69	postpones	postpone	VBZ
cord-258536-qnn9hp8e	277	70	apoptotic	apoptotic	JJ
cord-258536-qnn9hp8e	277	71	cell	cell	NN
cord-258536-qnn9hp8e	277	72	death	death	NN
cord-258536-qnn9hp8e	277	73	in	in	IN
cord-258536-qnn9hp8e	277	74	PRRSV	PRRSV	NNP
cord-258536-qnn9hp8e	277	75	infection	infection	NN
cord-258536-qnn9hp8e	277	76	through	through	IN
cord-258536-qnn9hp8e	277	77	Bad	Bad	NNP
cord-258536-qnn9hp8e	277	78	-	-	HYPH
cord-258536-qnn9hp8e	277	79	Beclin1	Beclin1	NNP
cord-258536-qnn9hp8e	277	80	interaction	interaction	NN
cord-258536-qnn9hp8e	277	81	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	277	82	replication	replication	NN
cord-258536-qnn9hp8e	277	83	complex	complex	JJ
cord-258536-qnn9hp8e	277	84	formation	formation	NN
cord-258536-qnn9hp8e	277	85	utilizes	utilize	VBZ
cord-258536-qnn9hp8e	277	86	components	component	NNS
cord-258536-qnn9hp8e	277	87	of	of	IN
cord-258536-qnn9hp8e	277	88	cellular	cellular	JJ
cord-258536-qnn9hp8e	277	89	autophagy	autophagy	NN
cord-258536-qnn9hp8e	277	90	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	277	91	replication	replication	NN
cord-258536-qnn9hp8e	277	92	does	do	VBZ
cord-258536-qnn9hp8e	277	93	not	not	RB
cord-258536-qnn9hp8e	277	94	require	require	VB
cord-258536-qnn9hp8e	277	95	the	the	DT
cord-258536-qnn9hp8e	277	96	autophagy	autophagy	NN
cord-258536-qnn9hp8e	277	97	gene	gene	NN
cord-258536-qnn9hp8e	277	98	ATG5	ATG5	NNP
cord-258536-qnn9hp8e	277	99	Coronaviruses	Coronaviruses	NNPS
cord-258536-qnn9hp8e	277	100	Hijack	hijack	VBP
cord-258536-qnn9hp8e	277	101	the	the	DT
cord-258536-qnn9hp8e	277	102	LC3-I	lc3-i	NN
cord-258536-qnn9hp8e	277	103	-	-	HYPH
cord-258536-qnn9hp8e	277	104	positive	positive	JJ
cord-258536-qnn9hp8e	277	105	EDEMosomes	edemosome	NNS
cord-258536-qnn9hp8e	277	106	,	,	,
cord-258536-qnn9hp8e	277	107	ER	ER	NNP
cord-258536-qnn9hp8e	277	108	-	-	HYPH
cord-258536-qnn9hp8e	277	109	derived	derive	VBN
cord-258536-qnn9hp8e	277	110	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	277	111	exporting	export	VBG
cord-258536-qnn9hp8e	277	112	short	short	RB
cord-258536-qnn9hp8e	277	113	-	-	HYPH
cord-258536-qnn9hp8e	277	114	lived	live	VBN
cord-258536-qnn9hp8e	277	115	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	277	116	regulators	regulator	NNS
cord-258536-qnn9hp8e	277	117	,	,	,
cord-258536-qnn9hp8e	277	118	for	for	IN
cord-258536-qnn9hp8e	277	119	replication	replication	NN
cord-258536-qnn9hp8e	277	120	An	an	DT
cord-258536-qnn9hp8e	277	121	autophagy	autophagy	NN
cord-258536-qnn9hp8e	277	122	-	-	HYPH
cord-258536-qnn9hp8e	277	123	independent	independent	JJ
cord-258536-qnn9hp8e	277	124	role	role	NN
cord-258536-qnn9hp8e	277	125	for	for	IN
cord-258536-qnn9hp8e	277	126	LC3	lc3	NN
cord-258536-qnn9hp8e	277	127	in	in	IN
cord-258536-qnn9hp8e	277	128	equine	equine	JJ
cord-258536-qnn9hp8e	277	129	arteritis	arteritis	NN
cord-258536-qnn9hp8e	277	130	virus	virus	NN
cord-258536-qnn9hp8e	277	131	replication	replication	NN
cord-258536-qnn9hp8e	277	132	Clinical	clinical	JJ
cord-258536-qnn9hp8e	277	133	consequences	consequence	NNS
cord-258536-qnn9hp8e	277	134	of	of	IN
cord-258536-qnn9hp8e	277	135	exposing	expose	VBG
cord-258536-qnn9hp8e	277	136	pregnant	pregnant	JJ
cord-258536-qnn9hp8e	277	137	gilts	gilt	NNS
cord-258536-qnn9hp8e	277	138	to	to	IN
cord-258536-qnn9hp8e	277	139	strains	strain	NNS
cord-258536-qnn9hp8e	277	140	of	of	IN
cord-258536-qnn9hp8e	277	141	porcine	porcine	JJ
cord-258536-qnn9hp8e	277	142	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	277	143	and	and	CC
cord-258536-qnn9hp8e	277	144	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	277	145	syndrome	syndrome	NN
cord-258536-qnn9hp8e	277	146	(	(	-LRB-
cord-258536-qnn9hp8e	277	147	PRRS	PRRS	NNP
cord-258536-qnn9hp8e	277	148	)	)	-RRB-
cord-258536-qnn9hp8e	277	149	virus	virus	NN
cord-258536-qnn9hp8e	277	150	isolated	isolate	VBN
cord-258536-qnn9hp8e	277	151	from	from	IN
cord-258536-qnn9hp8e	277	152	field	field	NN
cord-258536-qnn9hp8e	277	153	cases	case	NNS
cord-258536-qnn9hp8e	277	154	of	of	IN
cord-258536-qnn9hp8e	277	155	"	"	``
cord-258536-qnn9hp8e	277	156	atypical	atypical	JJ
cord-258536-qnn9hp8e	277	157	Complete	complete	JJ
cord-258536-qnn9hp8e	277	158	genome	genome	NN
cord-258536-qnn9hp8e	277	159	analysis	analysis	NN
cord-258536-qnn9hp8e	277	160	of	of	IN
cord-258536-qnn9hp8e	277	161	RFLP	RFLP	NNP
cord-258536-qnn9hp8e	277	162	184	184	CD
cord-258536-qnn9hp8e	277	163	isolates	isolate	NNS
cord-258536-qnn9hp8e	277	164	of	of	IN
cord-258536-qnn9hp8e	277	165	porcine	porcine	JJ
cord-258536-qnn9hp8e	277	166	reproductive	reproductive	JJ
cord-258536-qnn9hp8e	277	167	and	and	CC
cord-258536-qnn9hp8e	277	168	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	277	169	syndrome	syndrome	NN
cord-258536-qnn9hp8e	277	170	virus	virus	NN
cord-258536-qnn9hp8e	277	171	Equine	equine	JJ
cord-258536-qnn9hp8e	277	172	arteritis	arteritis	NN
cord-258536-qnn9hp8e	277	173	virus	virus	NN
cord-258536-qnn9hp8e	277	174	:	:	:
cord-258536-qnn9hp8e	277	175	A	a	DT
cord-258536-qnn9hp8e	277	176	review	review	NN
cord-258536-qnn9hp8e	277	177	of	of	IN
cord-258536-qnn9hp8e	277	178	clinical	clinical	JJ
cord-258536-qnn9hp8e	277	179	features	feature	NNS
cord-258536-qnn9hp8e	277	180	and	and	CC
cord-258536-qnn9hp8e	277	181	management	management	NN
cord-258536-qnn9hp8e	277	182	aspects	aspect	NNS
cord-258536-qnn9hp8e	277	183	Production	production	NN
cord-258536-qnn9hp8e	277	184	and	and	CC
cord-258536-qnn9hp8e	277	185	characterization	characterization	NN
cord-258536-qnn9hp8e	277	186	of	of	IN
cord-258536-qnn9hp8e	277	187	a	a	DT
cord-258536-qnn9hp8e	277	188	monoclonal	monoclonal	JJ
cord-258536-qnn9hp8e	277	189	antibody	antibody	NN
cord-258536-qnn9hp8e	277	190	against	against	IN
cord-258536-qnn9hp8e	277	191	spike	spike	NN
cord-258536-qnn9hp8e	277	192	protein	protein	NN
cord-258536-qnn9hp8e	277	193	of	of	IN
cord-258536-qnn9hp8e	277	194	transmissible	transmissible	JJ
cord-258536-qnn9hp8e	277	195	gastroenteritis	gastroenteritis	NN
cord-258536-qnn9hp8e	277	196	virus	virus	NN
cord-258536-qnn9hp8e	277	197	Porcine	porcine	JJ
cord-258536-qnn9hp8e	277	198	epidemic	epidemic	NN
cord-258536-qnn9hp8e	277	199	diarrhoea	diarrhoea	NN
cord-258536-qnn9hp8e	277	200	virus	virus	NN
cord-258536-qnn9hp8e	277	201	:	:	:
cord-258536-qnn9hp8e	277	202	A	a	DT
cord-258536-qnn9hp8e	277	203	comprehensive	comprehensive	JJ
cord-258536-qnn9hp8e	277	204	review	review	NN
cord-258536-qnn9hp8e	277	205	of	of	IN
cord-258536-qnn9hp8e	277	206	molecular	molecular	JJ
cord-258536-qnn9hp8e	277	207	epidemiology	epidemiology	NN
cord-258536-qnn9hp8e	277	208	,	,	,
cord-258536-qnn9hp8e	277	209	diagnosis	diagnosis	NN
cord-258536-qnn9hp8e	277	210	,	,	,
cord-258536-qnn9hp8e	277	211	and	and	CC
cord-258536-qnn9hp8e	277	212	vaccines	vaccine	NNS
cord-258536-qnn9hp8e	277	213	Human	human	JJ
cord-258536-qnn9hp8e	277	214	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	277	215	NL63	NL63	NNP
cord-258536-qnn9hp8e	277	216	,	,	,
cord-258536-qnn9hp8e	277	217	a	a	DT
cord-258536-qnn9hp8e	277	218	new	new	JJ
cord-258536-qnn9hp8e	277	219	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	277	220	virus	virus	NN
cord-258536-qnn9hp8e	278	1	Understanding	understand	VBG
cord-258536-qnn9hp8e	278	2	Human	Human	NNP
cord-258536-qnn9hp8e	278	3	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	278	4	HCoV	HCoV	.
cord-258536-qnn9hp8e	279	1	-NL63	-NL63	:
cord-258536-qnn9hp8e	279	2	Analysis	analysis	NN
cord-258536-qnn9hp8e	279	3	of	of	IN
cord-258536-qnn9hp8e	279	4	protein	protein	NN
cord-258536-qnn9hp8e	279	5	expression	expression	NN
cord-258536-qnn9hp8e	279	6	changes	change	NNS
cord-258536-qnn9hp8e	279	7	of	of	IN
cord-258536-qnn9hp8e	279	8	the	the	DT
cord-258536-qnn9hp8e	279	9	Vero	Vero	NNP
cord-258536-qnn9hp8e	279	10	E6	E6	NNP
cord-258536-qnn9hp8e	279	11	cells	cell	NNS
cord-258536-qnn9hp8e	279	12	infected	infect	VBN
cord-258536-qnn9hp8e	279	13	with	with	IN
cord-258536-qnn9hp8e	279	14	classic	classic	JJ
cord-258536-qnn9hp8e	279	15	PEDV	PEDV	NNP
cord-258536-qnn9hp8e	279	16	strain	strain	NN
cord-258536-qnn9hp8e	279	17	CV777	CV777	NNP
cord-258536-qnn9hp8e	279	18	by	by	IN
cord-258536-qnn9hp8e	279	19	using	use	VBG
cord-258536-qnn9hp8e	279	20	quantitative	quantitative	JJ
cord-258536-qnn9hp8e	279	21	proteomic	proteomic	JJ
cord-258536-qnn9hp8e	279	22	technique	technique	NN
cord-258536-qnn9hp8e	279	23	Porcine	Porcine	NNP
cord-258536-qnn9hp8e	279	24	Epidemic	epidemic	NN
cord-258536-qnn9hp8e	279	25	Diarrhea	diarrhea	NN
cord-258536-qnn9hp8e	279	26	Virus	virus	NN
cord-258536-qnn9hp8e	280	1	Induces	induce	VBZ
cord-258536-qnn9hp8e	280	2	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	281	1	to	to	TO
cord-258536-qnn9hp8e	281	2	Benefit	benefit	VB
cord-258536-qnn9hp8e	281	3	Its	-PRON-	PRP$
cord-258536-qnn9hp8e	281	4	Replication	Replication	NNP
cord-258536-qnn9hp8e	281	5	Mitophagy	Mitophagy	NNP
cord-258536-qnn9hp8e	281	6	in	in	IN
cord-258536-qnn9hp8e	281	7	TGEV	TGEV	NNP
cord-258536-qnn9hp8e	281	8	infection	infection	NN
cord-258536-qnn9hp8e	281	9	counteracts	counteract	VBZ
cord-258536-qnn9hp8e	281	10	oxidative	oxidative	JJ
cord-258536-qnn9hp8e	281	11	stress	stress	NN
cord-258536-qnn9hp8e	281	12	and	and	CC
cord-258536-qnn9hp8e	281	13	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	281	14	RNA	RNA	NNP
cord-258536-qnn9hp8e	281	15	replication	replication	NN
cord-258536-qnn9hp8e	281	16	of	of	IN
cord-258536-qnn9hp8e	281	17	mouse	mouse	NN
cord-258536-qnn9hp8e	281	18	hepatitis	hepatitis	NNP
cord-258536-qnn9hp8e	281	19	virus	virus	NN
cord-258536-qnn9hp8e	281	20	takes	take	VBZ
cord-258536-qnn9hp8e	281	21	place	place	NN
cord-258536-qnn9hp8e	281	22	at	at	IN
cord-258536-qnn9hp8e	281	23	double	double	JJ
cord-258536-qnn9hp8e	281	24	-	-	HYPH
cord-258536-qnn9hp8e	281	25	membrane	membrane	NN
cord-258536-qnn9hp8e	281	26	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	281	27	Identification	identification	NN
cord-258536-qnn9hp8e	281	28	and	and	CC
cord-258536-qnn9hp8e	281	29	characterization	characterization	NN
cord-258536-qnn9hp8e	281	30	of	of	IN
cord-258536-qnn9hp8e	281	31	severe	severe	JJ
cord-258536-qnn9hp8e	281	32	acute	acute	JJ
cord-258536-qnn9hp8e	281	33	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	281	34	syndrome	syndrome	NN
cord-258536-qnn9hp8e	281	35	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	281	36	replicase	replicase	NN
cord-258536-qnn9hp8e	281	37	proteins	protein	VBZ
cord-258536-qnn9hp8e	281	38	Ultrastructure	Ultrastructure	NNP
cord-258536-qnn9hp8e	281	39	and	and	CC
cord-258536-qnn9hp8e	281	40	origin	origin	NN
cord-258536-qnn9hp8e	281	41	of	of	IN
cord-258536-qnn9hp8e	281	42	membrane	membrane	NN
cord-258536-qnn9hp8e	281	43	vesicles	vesicle	NNS
cord-258536-qnn9hp8e	281	44	associated	associate	VBN
cord-258536-qnn9hp8e	281	45	with	with	IN
cord-258536-qnn9hp8e	281	46	the	the	DT
cord-258536-qnn9hp8e	281	47	severe	severe	JJ
cord-258536-qnn9hp8e	281	48	acute	acute	JJ
cord-258536-qnn9hp8e	281	49	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	281	50	syndrome	syndrome	NN
cord-258536-qnn9hp8e	281	51	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	281	52	replication	replication	NN
cord-258536-qnn9hp8e	281	53	complex	complex	JJ
cord-258536-qnn9hp8e	281	54	SARS	SARS	NNP
cord-258536-qnn9hp8e	281	55	-	-	HYPH
cord-258536-qnn9hp8e	281	56	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	281	57	replication	replication	NN
cord-258536-qnn9hp8e	282	1	is	be	VBZ
cord-258536-qnn9hp8e	282	2	supported	support	VBN
cord-258536-qnn9hp8e	282	3	by	by	IN
cord-258536-qnn9hp8e	282	4	a	a	DT
cord-258536-qnn9hp8e	282	5	reticulovesicular	reticulovesicular	JJ
cord-258536-qnn9hp8e	282	6	network	network	NN
cord-258536-qnn9hp8e	282	7	of	of	IN
cord-258536-qnn9hp8e	282	8	modified	modify	VBN
cord-258536-qnn9hp8e	282	9	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	282	10	reticulum	reticulum	NN
cord-258536-qnn9hp8e	282	11	Localization	localization	NN
cord-258536-qnn9hp8e	282	12	and	and	CC
cord-258536-qnn9hp8e	282	13	membrane	membrane	NN
cord-258536-qnn9hp8e	282	14	topology	topology	NN
cord-258536-qnn9hp8e	282	15	of	of	IN
cord-258536-qnn9hp8e	282	16	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	282	17	nonstructural	nonstructural	JJ
cord-258536-qnn9hp8e	282	18	protein	protein	NN
cord-258536-qnn9hp8e	282	19	4	4	CD
cord-258536-qnn9hp8e	282	20	:	:	:
cord-258536-qnn9hp8e	282	21	Involvement	involvement	NN
cord-258536-qnn9hp8e	282	22	of	of	IN
cord-258536-qnn9hp8e	282	23	the	the	DT
cord-258536-qnn9hp8e	282	24	early	early	JJ
cord-258536-qnn9hp8e	282	25	secretory	secretory	JJ
cord-258536-qnn9hp8e	282	26	pathway	pathway	NN
cord-258536-qnn9hp8e	282	27	in	in	IN
cord-258536-qnn9hp8e	282	28	replication	replication	NN
cord-258536-qnn9hp8e	282	29	Integrity	integrity	NN
cord-258536-qnn9hp8e	282	30	of	of	IN
cord-258536-qnn9hp8e	282	31	the	the	DT
cord-258536-qnn9hp8e	282	32	early	early	JJ
cord-258536-qnn9hp8e	282	33	secretory	secretory	JJ
cord-258536-qnn9hp8e	282	34	pathway	pathway	NN
cord-258536-qnn9hp8e	282	35	promotes	promote	VBZ
cord-258536-qnn9hp8e	282	36	,	,	,
cord-258536-qnn9hp8e	282	37	but	but	CC
cord-258536-qnn9hp8e	282	38	is	be	VBZ
cord-258536-qnn9hp8e	282	39	not	not	RB
cord-258536-qnn9hp8e	282	40	required	require	VBN
cord-258536-qnn9hp8e	282	41	for	for	IN
cord-258536-qnn9hp8e	282	42	,	,	,
cord-258536-qnn9hp8e	282	43	severe	severe	JJ
cord-258536-qnn9hp8e	282	44	acute	acute	JJ
cord-258536-qnn9hp8e	282	45	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	282	46	syndrome	syndrome	NN
cord-258536-qnn9hp8e	282	47	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	282	48	RNA	RNA	NNP
cord-258536-qnn9hp8e	282	49	synthesis	synthesis	NN
cord-258536-qnn9hp8e	282	50	and	and	CC
cord-258536-qnn9hp8e	282	51	virus	virus	NN
cord-258536-qnn9hp8e	282	52	-	-	HYPH
cord-258536-qnn9hp8e	282	53	induced	induce	VBN
cord-258536-qnn9hp8e	282	54	remodeling	remodeling	NN
cord-258536-qnn9hp8e	282	55	of	of	IN
cord-258536-qnn9hp8e	282	56	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	282	57	reticulum	reticulum	NN
cord-258536-qnn9hp8e	282	58	membranes	membrane	NNS
cord-258536-qnn9hp8e	282	59	Disposal	Disposal	NNP
cord-258536-qnn9hp8e	282	60	of	of	IN
cord-258536-qnn9hp8e	282	61	cargo	cargo	NN
cord-258536-qnn9hp8e	282	62	and	and	CC
cord-258536-qnn9hp8e	282	63	of	of	IN
cord-258536-qnn9hp8e	282	64	ERAD	ERAD	NNP
cord-258536-qnn9hp8e	282	65	regulators	regulator	NNS
cord-258536-qnn9hp8e	282	66	from	from	IN
cord-258536-qnn9hp8e	282	67	the	the	DT
cord-258536-qnn9hp8e	282	68	mammalian	mammalian	JJ
cord-258536-qnn9hp8e	282	69	ER	ER	NNP
cord-258536-qnn9hp8e	282	70	Discovery	Discovery	NNP
cord-258536-qnn9hp8e	282	71	of	of	IN
cord-258536-qnn9hp8e	282	72	Atg5	Atg5	NNP
cord-258536-qnn9hp8e	282	73	/	/	SYM
cord-258536-qnn9hp8e	282	74	Atg7-independent	Atg7-independent	NNP
cord-258536-qnn9hp8e	282	75	alternative	alternative	JJ
cord-258536-qnn9hp8e	282	76	macroautophagy	macroautophagy	NNS
cord-258536-qnn9hp8e	282	77	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	282	78	nsp6	nsp6	NN
cord-258536-qnn9hp8e	282	79	proteins	protein	NNS
cord-258536-qnn9hp8e	282	80	generate	generate	VBP
cord-258536-qnn9hp8e	282	81	autophagosomes	autophagosome	NNS
cord-258536-qnn9hp8e	282	82	from	from	IN
cord-258536-qnn9hp8e	282	83	the	the	DT
cord-258536-qnn9hp8e	282	84	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	282	85	reticulum	reticulum	NN
cord-258536-qnn9hp8e	282	86	via	via	IN
cord-258536-qnn9hp8e	282	87	an	an	DT
cord-258536-qnn9hp8e	282	88	omegasome	omegasome	NN
cord-258536-qnn9hp8e	282	89	intermediate	intermediate	JJ
cord-258536-qnn9hp8e	282	90	Endoplasmic	Endoplasmic	NNP
cord-258536-qnn9hp8e	282	91	reticulum	reticulum	NN
cord-258536-qnn9hp8e	282	92	stress	stress	NN
cord-258536-qnn9hp8e	282	93	triggers	trigger	VBZ
cord-258536-qnn9hp8e	283	1	autophagy	autophagy	NN
cord-258536-qnn9hp8e	284	1	The	the	DT
cord-258536-qnn9hp8e	284	2	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	284	3	spike	spike	NN
cord-258536-qnn9hp8e	284	4	protein	protein	NN
cord-258536-qnn9hp8e	284	5	induces	induce	VBZ
cord-258536-qnn9hp8e	284	6	endoplasmic	endoplasmic	NN
cord-258536-qnn9hp8e	284	7	reticulum	reticulum	NN
cord-258536-qnn9hp8e	284	8	stress	stress	NN
cord-258536-qnn9hp8e	284	9	and	and	CC
cord-258536-qnn9hp8e	284	10	upregulation	upregulation	NN
cord-258536-qnn9hp8e	284	11	of	of	IN
cord-258536-qnn9hp8e	284	12	intracellular	intracellular	JJ
cord-258536-qnn9hp8e	284	13	chemokine	chemokine	NN
cord-258536-qnn9hp8e	285	1	mRNA	mRNA	NNP
cord-258536-qnn9hp8e	285	2	concentrations	concentration	NNS
cord-258536-qnn9hp8e	285	3	Severe	severe	JJ
cord-258536-qnn9hp8e	286	1	acute	acute	JJ
cord-258536-qnn9hp8e	286	2	respiratory	respiratory	JJ
cord-258536-qnn9hp8e	286	3	syndrome	syndrome	NN
cord-258536-qnn9hp8e	286	4	coronavirus	coronavirus	NN
cord-258536-qnn9hp8e	286	5	envelope	envelope	NN
cord-258536-qnn9hp8e	286	6	protein	protein	NN
cord-258536-qnn9hp8e	286	7	regulates	regulate	VBZ
cord-258536-qnn9hp8e	286	8	cell	cell	NN
cord-258536-qnn9hp8e	286	9	stress	stress	NN
cord-258536-qnn9hp8e	286	10	response	response	NN
cord-258536-qnn9hp8e	286	11	and	and	CC
cord-258536-qnn9hp8e	286	12	apoptosis	apoptosis	NN
cord-258536-qnn9hp8e	286	13	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	286	14	membrane	membrane	NN
cord-258536-qnn9hp8e	286	15	-	-	HYPH
cord-258536-qnn9hp8e	286	16	associated	associate	VBN
cord-258536-qnn9hp8e	286	17	papain	papain	NN
cord-258536-qnn9hp8e	286	18	-	-	HYPH
cord-258536-qnn9hp8e	286	19	like	like	JJ
cord-258536-qnn9hp8e	286	20	proteases	protease	NNS
cord-258536-qnn9hp8e	286	21	induce	induce	VBP
cord-258536-qnn9hp8e	286	22	autophagy	autophagy	NN
cord-258536-qnn9hp8e	286	23	through	through	IN
cord-258536-qnn9hp8e	286	24	interacting	interact	VBG
cord-258536-qnn9hp8e	286	25	with	with	IN
cord-258536-qnn9hp8e	286	26	Beclin1	Beclin1	NNP
cord-258536-qnn9hp8e	286	27	to	to	TO
cord-258536-qnn9hp8e	286	28	negatively	negatively	RB
cord-258536-qnn9hp8e	286	29	regulate	regulate	VB
cord-258536-qnn9hp8e	286	30	antiviral	antiviral	JJ
cord-258536-qnn9hp8e	286	31	innate	innate	JJ
cord-258536-qnn9hp8e	286	32	immunity	immunity	NN
cord-258536-qnn9hp8e	286	33	Coronavirus	Coronavirus	NNP
cord-258536-qnn9hp8e	286	34	NSP6	NSP6	NNP
cord-258536-qnn9hp8e	286	35	restricts	restrict	VBZ
cord-258536-qnn9hp8e	286	36	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	286	37	expansion	expansion	NN
cord-258536-qnn9hp8e	286	38	LC3-Associated	lc3-associate	VBD
cord-258536-qnn9hp8e	286	39	Phagocytosis	Phagocytosis	NNP
cord-258536-qnn9hp8e	286	40	(	(	-LRB-
cord-258536-qnn9hp8e	286	41	LAP	lap	NN
cord-258536-qnn9hp8e	286	42	)	)	-RRB-
cord-258536-qnn9hp8e	287	1	:	:	:
cord-258536-qnn9hp8e	287	2	Connections	connection	NNS
cord-258536-qnn9hp8e	287	3	with	with	IN
cord-258536-qnn9hp8e	287	4	Host	Host	NNP
cord-258536-qnn9hp8e	287	5	Autophagy	Autophagy	NNP
cord-258536-qnn9hp8e	287	6	.	.	.
cord-258536-qnn9hp8e	288	1	Cells	cell	NNS
cord-258536-qnn9hp8e	288	2	Matrix	Matrix	NNP
cord-258536-qnn9hp8e	288	3	protein	protein	NN
cord-258536-qnn9hp8e	288	4	2	2	CD
cord-258536-qnn9hp8e	288	5	of	of	IN
cord-258536-qnn9hp8e	288	6	influenza	influenza	NN
cord-258536-qnn9hp8e	288	7	A	a	DT
cord-258536-qnn9hp8e	288	8	virus	virus	NN
cord-258536-qnn9hp8e	288	9	blocks	block	VBZ
cord-258536-qnn9hp8e	288	10	autophagosome	autophagosome	JJ
cord-258536-qnn9hp8e	288	11	fusion	fusion	NN
cord-258536-qnn9hp8e	288	12	with	with	IN
cord-258536-qnn9hp8e	288	13	lysosomes	lysosome	NNS
cord-258536-qnn9hp8e	288	14	Epstein	Epstein	NNP
cord-258536-qnn9hp8e	288	15	-	-	HYPH
cord-258536-qnn9hp8e	288	16	barr	barr	NNP
cord-258536-qnn9hp8e	288	17	virus	virus	NN
cord-258536-qnn9hp8e	289	1	blocks	block	VBZ
cord-258536-qnn9hp8e	289	2	the	the	DT
cord-258536-qnn9hp8e	289	3	autophagic	autophagic	NN
cord-258536-qnn9hp8e	289	4	flux	flux	NN
cord-258536-qnn9hp8e	289	5	and	and	CC
cord-258536-qnn9hp8e	289	6	appropriates	appropriate	VBZ
cord-258536-qnn9hp8e	289	7	the	the	DT
cord-258536-qnn9hp8e	289	8	autophagic	autophagic	JJ
cord-258536-qnn9hp8e	289	9	machinery	machinery	NN
cord-258536-qnn9hp8e	289	10	to	to	TO
cord-258536-qnn9hp8e	289	11	enhance	enhance	VB
cord-258536-qnn9hp8e	289	12	viral	viral	JJ
cord-258536-qnn9hp8e	289	13	replication	replication	NN
cord-258536-qnn9hp8e	289	14	Manipulation	manipulation	NN
cord-258536-qnn9hp8e	289	15	or	or	CC
cord-258536-qnn9hp8e	289	16	capitulation	capitulation	NN
cord-258536-qnn9hp8e	290	1	:	:	:
cord-258536-qnn9hp8e	290	2	Virus	virus	NN
cord-258536-qnn9hp8e	290	3	interactions	interaction	NNS
cord-258536-qnn9hp8e	290	4	with	with	IN
cord-258536-qnn9hp8e	290	5	autophagy	autophagy	NN
cord-258536-qnn9hp8e	290	6	.	.	.
cord-258536-qnn9hp8e	291	1	Microbes	microbe	NNS
cord-258536-qnn9hp8e	291	2	Infect	infect	VBP
cord-258536-qnn9hp8e	291	3	Author	author	NN
cord-258536-qnn9hp8e	291	4	Contributions	contribution	NNS
cord-258536-qnn9hp8e	291	5	:	:	:
cord-258536-qnn9hp8e	291	6	Y.C.	Y.C.	NNP
cord-258536-qnn9hp8e	291	7	,	,	,
cord-258536-qnn9hp8e	291	8	P.V.	P.V.	NNP
cord-258536-qnn9hp8e	291	9	and	and	CC
cord-258536-qnn9hp8e	291	10	F.R.	F.R.	NNP
cord-258536-qnn9hp8e	291	11	organized	organize	VBD
cord-258536-qnn9hp8e	291	12	all	all	DT
cord-258536-qnn9hp8e	291	13	related	related	JJ
cord-258536-qnn9hp8e	291	14	references	reference	NNS
cord-258536-qnn9hp8e	291	15	and	and	CC
cord-258536-qnn9hp8e	291	16	wrote	write	VBD
cord-258536-qnn9hp8e	291	17	the	the	DT
cord-258536-qnn9hp8e	291	18	manuscripts	manuscript	NNS
cord-258536-qnn9hp8e	291	19	.	.	.
cord-258536-qnn9hp8e	292	1	All	all	DT
cord-258536-qnn9hp8e	292	2	authors	author	NNS
cord-258536-qnn9hp8e	292	3	read	read	VBP
cord-258536-qnn9hp8e	292	4	and	and	CC
cord-258536-qnn9hp8e	292	5	approved	approve	VBD
cord-258536-qnn9hp8e	292	6	this	this	DT
cord-258536-qnn9hp8e	292	7	manuscript	manuscript	NN
cord-258536-qnn9hp8e	292	8	.	.	.
cord-258536-qnn9hp8e	293	1	The	the	DT
cord-258536-qnn9hp8e	293	2	authors	author	NNS
cord-258536-qnn9hp8e	293	3	declare	declare	VBP
cord-258536-qnn9hp8e	293	4	no	no	DT
cord-258536-qnn9hp8e	293	5	conflict	conflict	NN
cord-258536-qnn9hp8e	293	6	of	of	IN
cord-258536-qnn9hp8e	293	7	interest	interest	NN
cord-258536-qnn9hp8e	293	8	.	.	.