id sid tid token lemma pos cord-299038-e0nsol3y 1 1 key key JJ cord-299038-e0nsol3y 2 1 : : : cord-299038-e0nsol3y 2 2 cord-299038-e0nsol3y cord-299038-e0nsol3y NN cord-299038-e0nsol3y 2 3 authors author NNS cord-299038-e0nsol3y 2 4 : : : cord-299038-e0nsol3y 2 5 Chang Chang NNP cord-299038-e0nsol3y 2 6 , , , cord-299038-e0nsol3y 2 7 Yung Yung NNP cord-299038-e0nsol3y 2 8 - - HYPH cord-299038-e0nsol3y 2 9 Chi Chi NNP cord-299038-e0nsol3y 2 10 ; ; : cord-299038-e0nsol3y 2 11 Nizet Nizet NNP cord-299038-e0nsol3y 2 12 , , , cord-299038-e0nsol3y 3 1 Victor Victor NNP cord-299038-e0nsol3y 3 2 title title NN cord-299038-e0nsol3y 3 3 : : : cord-299038-e0nsol3y 4 1 Siglecs Siglecs NNP cord-299038-e0nsol3y 4 2 at at IN cord-299038-e0nsol3y 4 3 the the DT cord-299038-e0nsol3y 4 4 Host Host NNP cord-299038-e0nsol3y 4 5 – – : cord-299038-e0nsol3y 4 6 Pathogen Pathogen NNP cord-299038-e0nsol3y 4 7 Interface Interface NNP cord-299038-e0nsol3y 4 8 date date NN cord-299038-e0nsol3y 5 1 : : : cord-299038-e0nsol3y 5 2 2020 2020 CD cord-299038-e0nsol3y 5 3 - - HYPH cord-299038-e0nsol3y 5 4 03 03 CD cord-299038-e0nsol3y 5 5 - - SYM cord-299038-e0nsol3y 5 6 10 10 CD cord-299038-e0nsol3y 5 7 journal journal NN cord-299038-e0nsol3y 5 8 : : : cord-299038-e0nsol3y 5 9 Lectin Lectin NNP cord-299038-e0nsol3y 5 10 in in IN cord-299038-e0nsol3y 5 11 Host Host NNP cord-299038-e0nsol3y 5 12 Defense Defense NNP cord-299038-e0nsol3y 5 13 Against against IN cord-299038-e0nsol3y 5 14 Microbial Microbial NNP cord-299038-e0nsol3y 5 15 Infections Infections NNPS cord-299038-e0nsol3y 5 16 DOI DOI NNP cord-299038-e0nsol3y 5 17 : : : cord-299038-e0nsol3y 6 1 10.1007/978 10.1007/978 LS cord-299038-e0nsol3y 6 2 - - SYM cord-299038-e0nsol3y 6 3 981 981 CD cord-299038-e0nsol3y 6 4 - - HYPH cord-299038-e0nsol3y 6 5 15 15 CD cord-299038-e0nsol3y 6 6 - - HYPH cord-299038-e0nsol3y 6 7 1580 1580 CD cord-299038-e0nsol3y 6 8 - - SYM cord-299038-e0nsol3y 6 9 4_8 4_8 CD cord-299038-e0nsol3y 6 10 sha sha NNP cord-299038-e0nsol3y 6 11 : : : cord-299038-e0nsol3y 7 1 64929e24b974a401e62f2af92abda931af8b9342 64929e24b974a401e62f2af92abda931af8b9342 CD cord-299038-e0nsol3y 8 1 doc_id doc_id CD cord-299038-e0nsol3y 8 2 : : : cord-299038-e0nsol3y 8 3 299038 299038 CD cord-299038-e0nsol3y 8 4 cord_uid cord_uid NNS cord-299038-e0nsol3y 8 5 : : : cord-299038-e0nsol3y 9 1 e0nsol3y e0nsol3y NFP cord-299038-e0nsol3y 9 2 Siglecs Siglecs NNP cord-299038-e0nsol3y 9 3 are be VBP cord-299038-e0nsol3y 9 4 sialic sialic JJ cord-299038-e0nsol3y 9 5 acid acid NN cord-299038-e0nsol3y 9 6 ( ( -LRB- cord-299038-e0nsol3y 9 7 Sia Sia NNP cord-299038-e0nsol3y 9 8 ) ) -RRB- cord-299038-e0nsol3y 9 9 recognizing recognize VBG cord-299038-e0nsol3y 9 10 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 9 11 - - HYPH cord-299038-e0nsol3y 9 12 like like JJ cord-299038-e0nsol3y 9 13 receptors receptor NNS cord-299038-e0nsol3y 9 14 expressed express VBN cord-299038-e0nsol3y 9 15 on on IN cord-299038-e0nsol3y 9 16 the the DT cord-299038-e0nsol3y 9 17 surface surface NN cord-299038-e0nsol3y 9 18 of of IN cord-299038-e0nsol3y 9 19 all all PDT cord-299038-e0nsol3y 9 20 the the DT cord-299038-e0nsol3y 9 21 major major JJ cord-299038-e0nsol3y 9 22 leukocyte leukocyte NN cord-299038-e0nsol3y 9 23 lineages lineage NNS cord-299038-e0nsol3y 9 24 in in IN cord-299038-e0nsol3y 9 25 mammals mammal NNS cord-299038-e0nsol3y 9 26 . . . cord-299038-e0nsol3y 10 1 Siglecs Siglecs NNP cord-299038-e0nsol3y 10 2 recognize recognize VBP cord-299038-e0nsol3y 10 3 ubiquitous ubiquitous JJ cord-299038-e0nsol3y 10 4 Sia Sia NNP cord-299038-e0nsol3y 10 5 epitopes epitope NNS cord-299038-e0nsol3y 10 6 on on IN cord-299038-e0nsol3y 10 7 various various JJ cord-299038-e0nsol3y 10 8 glycoconjugates glycoconjugate NNS cord-299038-e0nsol3y 10 9 in in IN cord-299038-e0nsol3y 10 10 the the DT cord-299038-e0nsol3y 10 11 cell cell NN cord-299038-e0nsol3y 10 12 glycocalyx glycocalyx NN cord-299038-e0nsol3y 10 13 and and CC cord-299038-e0nsol3y 10 14 transduce transduce VB cord-299038-e0nsol3y 10 15 signals signal NNS cord-299038-e0nsol3y 10 16 to to TO cord-299038-e0nsol3y 10 17 regulate regulate VB cord-299038-e0nsol3y 10 18 immunological immunological JJ cord-299038-e0nsol3y 10 19 and and CC cord-299038-e0nsol3y 10 20 inflammatory inflammatory JJ cord-299038-e0nsol3y 10 21 activities activity NNS cord-299038-e0nsol3y 10 22 of of IN cord-299038-e0nsol3y 10 23 these these DT cord-299038-e0nsol3y 10 24 cells cell NNS cord-299038-e0nsol3y 10 25 . . . cord-299038-e0nsol3y 11 1 The the DT cord-299038-e0nsol3y 11 2 subset subset JJ cord-299038-e0nsol3y 11 3 known know VBN cord-299038-e0nsol3y 11 4 as as IN cord-299038-e0nsol3y 11 5 CD33-related CD33-related NNP cord-299038-e0nsol3y 11 6 Siglecs Siglecs NNP cord-299038-e0nsol3y 11 7 is be VBZ cord-299038-e0nsol3y 11 8 principally principally RB cord-299038-e0nsol3y 11 9 inhibitory inhibitory JJ cord-299038-e0nsol3y 11 10 receptors receptor NNS cord-299038-e0nsol3y 11 11 that that WDT cord-299038-e0nsol3y 11 12 suppress suppress VBP cord-299038-e0nsol3y 11 13 leukocyte leukocyte NN cord-299038-e0nsol3y 11 14 activation activation NN cord-299038-e0nsol3y 11 15 , , , cord-299038-e0nsol3y 11 16 and and CC cord-299038-e0nsol3y 11 17 recent recent JJ cord-299038-e0nsol3y 11 18 research research NN cord-299038-e0nsol3y 11 19 has have VBZ cord-299038-e0nsol3y 11 20 shown show VBN cord-299038-e0nsol3y 11 21 that that IN cord-299038-e0nsol3y 11 22 a a DT cord-299038-e0nsol3y 11 23 number number NN cord-299038-e0nsol3y 11 24 of of IN cord-299038-e0nsol3y 11 25 bacterial bacterial JJ cord-299038-e0nsol3y 11 26 pathogens pathogen NNS cord-299038-e0nsol3y 11 27 use use VBP cord-299038-e0nsol3y 11 28 Sia Sia NNP cord-299038-e0nsol3y 11 29 mimicry mimicry NN cord-299038-e0nsol3y 11 30 to to TO cord-299038-e0nsol3y 11 31 engage engage VB cord-299038-e0nsol3y 11 32 these these DT cord-299038-e0nsol3y 11 33 Siglecs Siglecs NNP cord-299038-e0nsol3y 11 34 as as IN cord-299038-e0nsol3y 11 35 an an DT cord-299038-e0nsol3y 11 36 immune immune JJ cord-299038-e0nsol3y 11 37 evasion evasion NN cord-299038-e0nsol3y 11 38 strategy strategy NN cord-299038-e0nsol3y 11 39 . . . cord-299038-e0nsol3y 12 1 Conversely conversely RB cord-299038-e0nsol3y 12 2 , , , cord-299038-e0nsol3y 12 3 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 12 4 is be VBZ cord-299038-e0nsol3y 12 5 a a DT cord-299038-e0nsol3y 12 6 macrophage macrophage NN cord-299038-e0nsol3y 12 7 phagocytic phagocytic JJ cord-299038-e0nsol3y 12 8 receptor receptor NN cord-299038-e0nsol3y 12 9 that that WDT cord-299038-e0nsol3y 12 10 engages engage VBZ cord-299038-e0nsol3y 12 11 GBS GBS NNP cord-299038-e0nsol3y 12 12 and and CC cord-299038-e0nsol3y 12 13 other other JJ cord-299038-e0nsol3y 12 14 sialylated sialylated JJ cord-299038-e0nsol3y 12 15 bacteria bacteria NNS cord-299038-e0nsol3y 12 16 to to TO cord-299038-e0nsol3y 12 17 promote promote VB cord-299038-e0nsol3y 12 18 effective effective JJ cord-299038-e0nsol3y 12 19 phagocytosis phagocytosis NN cord-299038-e0nsol3y 12 20 and and CC cord-299038-e0nsol3y 12 21 antigen antigen NN cord-299038-e0nsol3y 12 22 presentation presentation NN cord-299038-e0nsol3y 12 23 for for IN cord-299038-e0nsol3y 12 24 the the DT cord-299038-e0nsol3y 12 25 adaptive adaptive JJ cord-299038-e0nsol3y 12 26 immune immune JJ cord-299038-e0nsol3y 12 27 response response NN cord-299038-e0nsol3y 12 28 , , , cord-299038-e0nsol3y 12 29 whereas whereas IN cord-299038-e0nsol3y 12 30 certain certain JJ cord-299038-e0nsol3y 12 31 viruses virus NNS cord-299038-e0nsol3y 12 32 and and CC cord-299038-e0nsol3y 12 33 parasites parasite NNS cord-299038-e0nsol3y 12 34 use use VBP cord-299038-e0nsol3y 12 35 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 12 36 to to TO cord-299038-e0nsol3y 12 37 gain gain VB cord-299038-e0nsol3y 12 38 entry entry NN cord-299038-e0nsol3y 12 39 to to IN cord-299038-e0nsol3y 12 40 immune immune JJ cord-299038-e0nsol3y 12 41 cells cell NNS cord-299038-e0nsol3y 12 42 as as IN cord-299038-e0nsol3y 12 43 a a DT cord-299038-e0nsol3y 12 44 proximal proximal JJ cord-299038-e0nsol3y 12 45 step step NN cord-299038-e0nsol3y 12 46 in in IN cord-299038-e0nsol3y 12 47 the the DT cord-299038-e0nsol3y 12 48 infectious infectious JJ cord-299038-e0nsol3y 12 49 process process NN cord-299038-e0nsol3y 12 50 . . . cord-299038-e0nsol3y 13 1 Siglecs Siglecs NNP cord-299038-e0nsol3y 13 2 are be VBP cord-299038-e0nsol3y 13 3 positioned position VBN cord-299038-e0nsol3y 13 4 in in IN cord-299038-e0nsol3y 13 5 crosstalk crosstalk NN cord-299038-e0nsol3y 13 6 with with IN cord-299038-e0nsol3y 13 7 other other JJ cord-299038-e0nsol3y 13 8 host host NN cord-299038-e0nsol3y 13 9 innate innate JJ cord-299038-e0nsol3y 13 10 immune immune JJ cord-299038-e0nsol3y 13 11 sensing sensing NN cord-299038-e0nsol3y 13 12 pathways pathway NNS cord-299038-e0nsol3y 13 13 to to TO cord-299038-e0nsol3y 13 14 modulate modulate VB cord-299038-e0nsol3y 13 15 the the DT cord-299038-e0nsol3y 13 16 immune immune JJ cord-299038-e0nsol3y 13 17 response response NN cord-299038-e0nsol3y 13 18 to to IN cord-299038-e0nsol3y 13 19 infection infection NN cord-299038-e0nsol3y 13 20 in in IN cord-299038-e0nsol3y 13 21 complex complex JJ cord-299038-e0nsol3y 13 22 ways way NNS cord-299038-e0nsol3y 13 23 . . . cord-299038-e0nsol3y 14 1 This this DT cord-299038-e0nsol3y 14 2 chapter chapter NN cord-299038-e0nsol3y 14 3 summarizes summarize VBZ cord-299038-e0nsol3y 14 4 the the DT cord-299038-e0nsol3y 14 5 current current JJ cord-299038-e0nsol3y 14 6 understanding understanding NN cord-299038-e0nsol3y 14 7 of of IN cord-299038-e0nsol3y 14 8 Siglecs Siglecs NNP cord-299038-e0nsol3y 14 9 at at IN cord-299038-e0nsol3y 14 10 the the DT cord-299038-e0nsol3y 14 11 host host NN cord-299038-e0nsol3y 14 12 – – : cord-299038-e0nsol3y 14 13 pathogen pathogen NN cord-299038-e0nsol3y 14 14 interface interface NN cord-299038-e0nsol3y 14 15 , , , cord-299038-e0nsol3y 14 16 a a DT cord-299038-e0nsol3y 14 17 field field NN cord-299038-e0nsol3y 14 18 of of IN cord-299038-e0nsol3y 14 19 study study NN cord-299038-e0nsol3y 14 20 expanding expand VBG cord-299038-e0nsol3y 14 21 in in IN cord-299038-e0nsol3y 14 22 breadth breadth NN cord-299038-e0nsol3y 14 23 and and CC cord-299038-e0nsol3y 14 24 medical medical JJ cord-299038-e0nsol3y 14 25 importance importance NN cord-299038-e0nsol3y 14 26 , , , cord-299038-e0nsol3y 14 27 and and CC cord-299038-e0nsol3y 14 28 which which WDT cord-299038-e0nsol3y 14 29 provides provide VBZ cord-299038-e0nsol3y 14 30 potential potential JJ cord-299038-e0nsol3y 14 31 targets target NNS cord-299038-e0nsol3y 14 32 for for IN cord-299038-e0nsol3y 14 33 immune immune NN cord-299038-e0nsol3y 14 34 - - HYPH cord-299038-e0nsol3y 14 35 based base VBN cord-299038-e0nsol3y 14 36 anti anti JJ cord-299038-e0nsol3y 14 37 - - JJ cord-299038-e0nsol3y 14 38 infective infective JJ cord-299038-e0nsol3y 14 39 strategies strategy NNS cord-299038-e0nsol3y 14 40 . . . cord-299038-e0nsol3y 15 1 Sialic Sialic NNP cord-299038-e0nsol3y 15 2 acid acid NN cord-299038-e0nsol3y 15 3 - - HYPH cord-299038-e0nsol3y 15 4 binding bind VBG cord-299038-e0nsol3y 15 5 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 15 6 - - HYPH cord-299038-e0nsol3y 15 7 type type NN cord-299038-e0nsol3y 15 8 lectins lectin NNS cord-299038-e0nsol3y 15 9 ( ( -LRB- cord-299038-e0nsol3y 15 10 Siglecs Siglecs NNP cord-299038-e0nsol3y 15 11 ) ) -RRB- cord-299038-e0nsol3y 15 12 are be VBP cord-299038-e0nsol3y 15 13 cell cell NN cord-299038-e0nsol3y 15 14 surface surface NN cord-299038-e0nsol3y 15 15 receptors receptor NNS cord-299038-e0nsol3y 15 16 belonging belong VBG cord-299038-e0nsol3y 15 17 to to IN cord-299038-e0nsol3y 15 18 the the DT cord-299038-e0nsol3y 15 19 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 15 20 ( ( -LRB- cord-299038-e0nsol3y 15 21 Ig Ig NNP cord-299038-e0nsol3y 15 22 ) ) -RRB- cord-299038-e0nsol3y 15 23 superfamily superfamily NN cord-299038-e0nsol3y 15 24 . . . cord-299038-e0nsol3y 16 1 The the DT cord-299038-e0nsol3y 16 2 extracellular extracellular JJ cord-299038-e0nsol3y 16 3 domains domain NNS cord-299038-e0nsol3y 16 4 of of IN cord-299038-e0nsol3y 16 5 these these DT cord-299038-e0nsol3y 16 6 receptors receptor NNS cord-299038-e0nsol3y 16 7 comprise comprise VBP cord-299038-e0nsol3y 16 8 one one CD cord-299038-e0nsol3y 16 9 ligand ligand NN cord-299038-e0nsol3y 16 10 - - HYPH cord-299038-e0nsol3y 16 11 binding bind VBG cord-299038-e0nsol3y 16 12 V v NN cord-299038-e0nsol3y 16 13 - - HYPH cord-299038-e0nsol3y 16 14 set set NN cord-299038-e0nsol3y 16 15 domain domain NN cord-299038-e0nsol3y 16 16 and and CC cord-299038-e0nsol3y 16 17 a a DT cord-299038-e0nsol3y 16 18 variable variable JJ cord-299038-e0nsol3y 16 19 number number NN cord-299038-e0nsol3y 16 20 of of IN cord-299038-e0nsol3y 16 21 C2-set C2-set NNP cord-299038-e0nsol3y 16 22 domains domain NNS cord-299038-e0nsol3y 16 23 , , , cord-299038-e0nsol3y 16 24 with with IN cord-299038-e0nsol3y 16 25 high high JJ cord-299038-e0nsol3y 16 26 - - HYPH cord-299038-e0nsol3y 16 27 sequence sequence NN cord-299038-e0nsol3y 16 28 similarities similarity NNS cord-299038-e0nsol3y 16 29 to to IN cord-299038-e0nsol3y 16 30 the the DT cord-299038-e0nsol3y 16 31 variable variable JJ cord-299038-e0nsol3y 16 32 and and CC cord-299038-e0nsol3y 16 33 constant constant JJ cord-299038-e0nsol3y 16 34 region region NN cord-299038-e0nsol3y 16 35 of of IN cord-299038-e0nsol3y 16 36 antibodies antibody NNS cord-299038-e0nsol3y 16 37 , , , cord-299038-e0nsol3y 16 38 respectively respectively RB cord-299038-e0nsol3y 16 39 . . . cord-299038-e0nsol3y 17 1 Siglecs Siglecs NNP cord-299038-e0nsol3y 17 2 are be VBP cord-299038-e0nsol3y 17 3 mostly mostly RB cord-299038-e0nsol3y 17 4 located locate VBN cord-299038-e0nsol3y 17 5 on on IN cord-299038-e0nsol3y 17 6 the the DT cord-299038-e0nsol3y 17 7 cell cell NN cord-299038-e0nsol3y 17 8 surface surface NN cord-299038-e0nsol3y 17 9 of of IN cord-299038-e0nsol3y 17 10 hematopoietic hematopoietic JJ cord-299038-e0nsol3y 17 11 cells cell NNS cord-299038-e0nsol3y 17 12 , , , cord-299038-e0nsol3y 17 13 with with IN cord-299038-e0nsol3y 17 14 the the DT cord-299038-e0nsol3y 17 15 exception exception NN cord-299038-e0nsol3y 17 16 of of IN cord-299038-e0nsol3y 17 17 Siglec-4 Siglec-4 NNP cord-299038-e0nsol3y 17 18 ( ( -LRB- cord-299038-e0nsol3y 17 19 Schwann Schwann NNP cord-299038-e0nsol3y 17 20 cells cell NNS cord-299038-e0nsol3y 17 21 ) ) -RRB- cord-299038-e0nsol3y 17 22 and and CC cord-299038-e0nsol3y 17 23 Siglec-6 Siglec-6 NNP cord-299038-e0nsol3y 17 24 ( ( -LRB- cord-299038-e0nsol3y 17 25 epithelial epithelial JJ cord-299038-e0nsol3y 17 26 cells cell NNS cord-299038-e0nsol3y 17 27 ) ) -RRB- cord-299038-e0nsol3y 17 28 . . . cord-299038-e0nsol3y 18 1 Until until IN cord-299038-e0nsol3y 18 2 now now RB cord-299038-e0nsol3y 18 3 , , , cord-299038-e0nsol3y 18 4 14 14 CD cord-299038-e0nsol3y 18 5 human human JJ cord-299038-e0nsol3y 18 6 Siglecs Siglecs NNP cord-299038-e0nsol3y 18 7 and and CC cord-299038-e0nsol3y 18 8 9 9 CD cord-299038-e0nsol3y 18 9 murine murine JJ cord-299038-e0nsol3y 18 10 Siglecs Siglecs NNP cord-299038-e0nsol3y 18 11 have have VBP cord-299038-e0nsol3y 18 12 been be VBN cord-299038-e0nsol3y 18 13 identified identify VBN cord-299038-e0nsol3y 18 14 with with IN cord-299038-e0nsol3y 18 15 different different JJ cord-299038-e0nsol3y 18 16 preferences preference NNS cord-299038-e0nsol3y 18 17 for for IN cord-299038-e0nsol3y 18 18 binding bind VBG cord-299038-e0nsol3y 18 19 to to IN cord-299038-e0nsol3y 18 20 terminal terminal JJ cord-299038-e0nsol3y 18 21 sialic sialic JJ cord-299038-e0nsol3y 18 22 acids acid NNS cord-299038-e0nsol3y 18 23 ( ( -LRB- cord-299038-e0nsol3y 18 24 Sia Sia NNP cord-299038-e0nsol3y 18 25 ) ) -RRB- cord-299038-e0nsol3y 18 26 on on IN cord-299038-e0nsol3y 18 27 glycan glycan NN cord-299038-e0nsol3y 18 28 structures structure NNS cord-299038-e0nsol3y 18 29 in in IN cord-299038-e0nsol3y 18 30 a a DT cord-299038-e0nsol3y 18 31 linkage linkage NN cord-299038-e0nsol3y 18 32 - - HYPH cord-299038-e0nsol3y 18 33 sensitive sensitive JJ cord-299038-e0nsol3y 18 34 fashion fashion NN cord-299038-e0nsol3y 18 35 . . . cord-299038-e0nsol3y 19 1 The the DT cord-299038-e0nsol3y 19 2 arginine arginine NN cord-299038-e0nsol3y 19 3 residue residue NN cord-299038-e0nsol3y 19 4 in in IN cord-299038-e0nsol3y 19 5 the the DT cord-299038-e0nsol3y 19 6 Siglec Siglec NNP cord-299038-e0nsol3y 19 7 V V NNP cord-299038-e0nsol3y 19 8 - - HYPH cord-299038-e0nsol3y 19 9 set set NN cord-299038-e0nsol3y 19 10 domain domain NN cord-299038-e0nsol3y 19 11 is be VBZ cord-299038-e0nsol3y 19 12 critical critical JJ cord-299038-e0nsol3y 19 13 for for IN cord-299038-e0nsol3y 19 14 contacting contact VBG cord-299038-e0nsol3y 19 15 the the DT cord-299038-e0nsol3y 19 16 carboxyl carboxyl NN cord-299038-e0nsol3y 19 17 group group NN cord-299038-e0nsol3y 19 18 of of IN cord-299038-e0nsol3y 19 19 the the DT cord-299038-e0nsol3y 19 20 Sia Sia NNP cord-299038-e0nsol3y 19 21 to to TO cord-299038-e0nsol3y 19 22 form form VB cord-299038-e0nsol3y 19 23 a a DT cord-299038-e0nsol3y 19 24 salt salt NN cord-299038-e0nsol3y 19 25 bridge bridge NN cord-299038-e0nsol3y 19 26 that that WDT cord-299038-e0nsol3y 19 27 stabilizes stabilize VBZ cord-299038-e0nsol3y 19 28 the the DT cord-299038-e0nsol3y 19 29 binding bind VBG cord-299038-e0nsol3y 19 30 interaction interaction NN cord-299038-e0nsol3y 19 31 . . . cord-299038-e0nsol3y 20 1 Phylogenetically phylogenetically RB cord-299038-e0nsol3y 20 2 , , , cord-299038-e0nsol3y 20 3 Siglec Siglec NNP cord-299038-e0nsol3y 20 4 family family NN cord-299038-e0nsol3y 20 5 members member NNS cord-299038-e0nsol3y 20 6 can can MD cord-299038-e0nsol3y 20 7 be be VB cord-299038-e0nsol3y 20 8 subdivided subdivide VBN cord-299038-e0nsol3y 20 9 into into IN cord-299038-e0nsol3y 20 10 two two CD cord-299038-e0nsol3y 20 11 groups group NNS cord-299038-e0nsol3y 20 12 : : : cord-299038-e0nsol3y 21 1 First first RB cord-299038-e0nsol3y 21 2 , , , cord-299038-e0nsol3y 21 3 there there EX cord-299038-e0nsol3y 21 4 are be VBP cord-299038-e0nsol3y 21 5 Siglecs Siglecs NNP cord-299038-e0nsol3y 21 6 that that WDT cord-299038-e0nsol3y 21 7 are be VBP cord-299038-e0nsol3y 21 8 conserved conserve VBN cord-299038-e0nsol3y 21 9 among among IN cord-299038-e0nsol3y 21 10 different different JJ cord-299038-e0nsol3y 21 11 species specie NNS cord-299038-e0nsol3y 21 12 , , , cord-299038-e0nsol3y 21 13 but but CC cord-299038-e0nsol3y 21 14 showing show VBG cord-299038-e0nsol3y 21 15 low low JJ cord-299038-e0nsol3y 21 16 - - HYPH cord-299038-e0nsol3y 21 17 sequence sequence NN cord-299038-e0nsol3y 21 18 identity identity NN cord-299038-e0nsol3y 21 19 to to IN cord-299038-e0nsol3y 21 20 one one CD cord-299038-e0nsol3y 21 21 another another DT cord-299038-e0nsol3y 21 22 , , , cord-299038-e0nsol3y 21 23 including include VBG cord-299038-e0nsol3y 21 24 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 21 25 , , , cord-299038-e0nsol3y 21 26 Siglec-2 Siglec-2 NNP cord-299038-e0nsol3y 21 27 , , , cord-299038-e0nsol3y 21 28 Siglec-4 Siglec-4 NNP cord-299038-e0nsol3y 21 29 , , , cord-299038-e0nsol3y 21 30 and and CC cord-299038-e0nsol3y 21 31 Siglec-15 Siglec-15 NNS cord-299038-e0nsol3y 21 32 . . . cord-299038-e0nsol3y 22 1 The the DT cord-299038-e0nsol3y 22 2 other other JJ cord-299038-e0nsol3y 22 3 group group NN cord-299038-e0nsol3y 22 4 comprises comprise VBZ cord-299038-e0nsol3y 22 5 the the DT cord-299038-e0nsol3y 22 6 so so RB cord-299038-e0nsol3y 22 7 - - HYPH cord-299038-e0nsol3y 22 8 called call VBN cord-299038-e0nsol3y 22 9 CD33 CD33 NNP cord-299038-e0nsol3y 22 10 ( ( -LRB- cord-299038-e0nsol3y 22 11 Siglec-3)-related siglec-3)-related JJ cord-299038-e0nsol3y 22 12 Siglecs Siglecs NNP cord-299038-e0nsol3y 22 13 ( ( -LRB- cord-299038-e0nsol3y 22 14 CD33rSiglecs CD33rSiglecs NNP cord-299038-e0nsol3y 22 15 ) ) -RRB- cord-299038-e0nsol3y 22 16 , , , cord-299038-e0nsol3y 22 17 which which WDT cord-299038-e0nsol3y 22 18 show show VBP cord-299038-e0nsol3y 22 19 low low JJ cord-299038-e0nsol3y 22 20 gene gene NN cord-299038-e0nsol3y 22 21 conservation conservation NN cord-299038-e0nsol3y 22 22 but but CC cord-299038-e0nsol3y 22 23 possess possess VBP cord-299038-e0nsol3y 22 24 higher high JJR cord-299038-e0nsol3y 22 25 degrees degree NNS cord-299038-e0nsol3y 22 26 of of IN cord-299038-e0nsol3y 22 27 sequence sequence NN cord-299038-e0nsol3y 22 28 identity identity NN cord-299038-e0nsol3y 22 29 among among IN cord-299038-e0nsol3y 22 30 the the DT cord-299038-e0nsol3y 22 31 subfamily subfamily NN cord-299038-e0nsol3y 22 32 members member NNS cord-299038-e0nsol3y 22 33 . . . cord-299038-e0nsol3y 23 1 Both both DT cord-299038-e0nsol3y 23 2 conserved conserve VBN cord-299038-e0nsol3y 23 3 Siglecs Siglecs NNP cord-299038-e0nsol3y 23 4 and and CC cord-299038-e0nsol3y 23 5 CD33rSiglecs CD33rSiglecs NNP cord-299038-e0nsol3y 23 6 include include VBP cord-299038-e0nsol3y 23 7 activating activate VBG cord-299038-e0nsol3y 23 8 and and CC cord-299038-e0nsol3y 23 9 inhibitory inhibitory JJ cord-299038-e0nsol3y 23 10 receptors receptor NNS cord-299038-e0nsol3y 23 11 . . . cord-299038-e0nsol3y 24 1 The the DT cord-299038-e0nsol3y 24 2 inhibitory inhibitory JJ cord-299038-e0nsol3y 24 3 Siglecs Siglecs NNP cord-299038-e0nsol3y 24 4 contain contain VBP cord-299038-e0nsol3y 24 5 an an DT cord-299038-e0nsol3y 24 6 immunoreceptor immunoreceptor NN cord-299038-e0nsol3y 24 7 - - HYPH cord-299038-e0nsol3y 24 8 based base VBN cord-299038-e0nsol3y 24 9 inhibition inhibition NN cord-299038-e0nsol3y 24 10 motif motif NN cord-299038-e0nsol3y 24 11 ( ( -LRB- cord-299038-e0nsol3y 24 12 ITIM ITIM NNP cord-299038-e0nsol3y 24 13 ) ) -RRB- cord-299038-e0nsol3y 24 14 in in IN cord-299038-e0nsol3y 24 15 their -PRON- PRP$ cord-299038-e0nsol3y 24 16 intracellular intracellular JJ cord-299038-e0nsol3y 24 17 domain domain NN cord-299038-e0nsol3y 24 18 , , , cord-299038-e0nsol3y 24 19 conferring confer VBG cord-299038-e0nsol3y 24 20 the the DT cord-299038-e0nsol3y 24 21 ability ability NN cord-299038-e0nsol3y 24 22 to to TO cord-299038-e0nsol3y 24 23 antagonize antagonize VB cord-299038-e0nsol3y 24 24 immune immune JJ cord-299038-e0nsol3y 24 25 signaling signal VBG cord-299038-e0nsol3y 24 26 pathways pathway NNS cord-299038-e0nsol3y 24 27 through through IN cord-299038-e0nsol3y 24 28 the the DT cord-299038-e0nsol3y 24 29 recruitment recruitment NN cord-299038-e0nsol3y 24 30 of of IN cord-299038-e0nsol3y 24 31 the the DT cord-299038-e0nsol3y 24 32 SHP SHP NNP cord-299038-e0nsol3y 24 33 phosphatases phosphatase NNS cord-299038-e0nsol3y 24 34 . . . cord-299038-e0nsol3y 25 1 Conversely conversely RB cord-299038-e0nsol3y 25 2 , , , cord-299038-e0nsol3y 25 3 activating activate VBG cord-299038-e0nsol3y 25 4 Siglecs Siglecs NNP cord-299038-e0nsol3y 25 5 have have VBP cord-299038-e0nsol3y 25 6 an an DT cord-299038-e0nsol3y 25 7 aspartic aspartic JJ cord-299038-e0nsol3y 25 8 acid acid NN cord-299038-e0nsol3y 25 9 residue residue NN cord-299038-e0nsol3y 25 10 in in IN cord-299038-e0nsol3y 25 11 their -PRON- PRP$ cord-299038-e0nsol3y 25 12 trans trans JJ cord-299038-e0nsol3y 25 13 - - NN cord-299038-e0nsol3y 25 14 membrane membrane NN cord-299038-e0nsol3y 25 15 domain domain NN cord-299038-e0nsol3y 25 16 that that WDT cord-299038-e0nsol3y 25 17 associates associate NNS cord-299038-e0nsol3y 25 18 with with IN cord-299038-e0nsol3y 25 19 immunoreceptor immunoreceptor NNP cord-299038-e0nsol3y 25 20 - - HYPH cord-299038-e0nsol3y 25 21 based base VBN cord-299038-e0nsol3y 25 22 activation activation NN cord-299038-e0nsol3y 25 23 motif motif NN cord-299038-e0nsol3y 25 24 ( ( -LRB- cord-299038-e0nsol3y 25 25 ITAM)-containing ITAM)-containing NNP cord-299038-e0nsol3y 25 26 adaptor adaptor NN cord-299038-e0nsol3y 25 27 DAP12 DAP12 NNP cord-299038-e0nsol3y 25 28 ( ( -LRB- cord-299038-e0nsol3y 25 29 DNAX DNAX NNP cord-299038-e0nsol3y 25 30 - - HYPH cord-299038-e0nsol3y 25 31 activation activation NN cord-299038-e0nsol3y 25 32 protein protein NN cord-299038-e0nsol3y 25 33 of of IN cord-299038-e0nsol3y 25 34 12 12 CD cord-299038-e0nsol3y 25 35 kDa kDa NNS cord-299038-e0nsol3y 25 36 ) ) -RRB- cord-299038-e0nsol3y 25 37 to to TO cord-299038-e0nsol3y 25 38 promote promote VB cord-299038-e0nsol3y 25 39 signaling signal VBG cord-299038-e0nsol3y 25 40 and and CC cord-299038-e0nsol3y 25 41 immune immune JJ cord-299038-e0nsol3y 25 42 responses response NNS cord-299038-e0nsol3y 25 43 . . . cord-299038-e0nsol3y 26 1 Lastly lastly RB cord-299038-e0nsol3y 26 2 , , , cord-299038-e0nsol3y 26 3 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 26 4 does do VBZ cord-299038-e0nsol3y 26 5 not not RB cord-299038-e0nsol3y 26 6 possess possess VB cord-299038-e0nsol3y 26 7 a a DT cord-299038-e0nsol3y 26 8 functional functional JJ cord-299038-e0nsol3y 26 9 intracellular intracellular JJ cord-299038-e0nsol3y 26 10 domain domain NN cord-299038-e0nsol3y 26 11 and and CC cord-299038-e0nsol3y 26 12 is be VBZ cord-299038-e0nsol3y 26 13 not not RB cord-299038-e0nsol3y 26 14 known know VBN cord-299038-e0nsol3y 26 15 to to TO cord-299038-e0nsol3y 26 16 signal signal VB cord-299038-e0nsol3y 26 17 directly directly RB cord-299038-e0nsol3y 26 18 , , , cord-299038-e0nsol3y 26 19 but but CC cord-299038-e0nsol3y 26 20 rather rather RB cord-299038-e0nsol3y 26 21 plays play VBZ cord-299038-e0nsol3y 26 22 a a DT cord-299038-e0nsol3y 26 23 role role NN cord-299038-e0nsol3y 26 24 in in IN cord-299038-e0nsol3y 26 25 cell cell NN cord-299038-e0nsol3y 26 26 - - HYPH cord-299038-e0nsol3y 26 27 cell cell NN cord-299038-e0nsol3y 26 28 and and CC cord-299038-e0nsol3y 26 29 cell cell NN cord-299038-e0nsol3y 26 30 - - HYPH cord-299038-e0nsol3y 26 31 microbe microbe NN cord-299038-e0nsol3y 26 32 interactions interaction NNS cord-299038-e0nsol3y 26 33 . . . cord-299038-e0nsol3y 27 1 Glycans glycan NNS cord-299038-e0nsol3y 27 2 are be VBP cord-299038-e0nsol3y 27 3 ubiquitous ubiquitous JJ cord-299038-e0nsol3y 27 4 on on IN cord-299038-e0nsol3y 27 5 eukaryotic eukaryotic JJ cord-299038-e0nsol3y 27 6 cell cell NN cord-299038-e0nsol3y 27 7 surfaces surface NNS cord-299038-e0nsol3y 27 8 via via IN cord-299038-e0nsol3y 27 9 their -PRON- PRP$ cord-299038-e0nsol3y 27 10 incorporation incorporation NN cord-299038-e0nsol3y 27 11 in in IN cord-299038-e0nsol3y 27 12 glycoproteins glycoprotein NNS cord-299038-e0nsol3y 27 13 , , , cord-299038-e0nsol3y 27 14 glycosphingolipids glycosphingolipid NNS cord-299038-e0nsol3y 27 15 , , , cord-299038-e0nsol3y 27 16 and and CC cord-299038-e0nsol3y 27 17 glycerophosphatides glycerophosphatide NNS cord-299038-e0nsol3y 27 18 . . . cord-299038-e0nsol3y 28 1 In in IN cord-299038-e0nsol3y 28 2 mammalian mammalian JJ cord-299038-e0nsol3y 28 3 cells cell NNS cord-299038-e0nsol3y 28 4 , , , cord-299038-e0nsol3y 28 5 Sia Sia NNP cord-299038-e0nsol3y 28 6 is be VBZ cord-299038-e0nsol3y 28 7 usually usually RB cord-299038-e0nsol3y 28 8 the the DT cord-299038-e0nsol3y 28 9 outmost outmost JJ cord-299038-e0nsol3y 28 10 sugar sugar NN cord-299038-e0nsol3y 28 11 residue residue NN cord-299038-e0nsol3y 28 12 on on IN cord-299038-e0nsol3y 28 13 the the DT cord-299038-e0nsol3y 28 14 oligosaccharide oligosaccharide NN cord-299038-e0nsol3y 28 15 chains chain NNS cord-299038-e0nsol3y 28 16 of of IN cord-299038-e0nsol3y 28 17 cell cell NN cord-299038-e0nsol3y 28 18 surface surface NN cord-299038-e0nsol3y 28 19 or or CC cord-299038-e0nsol3y 28 20 serum serum NN cord-299038-e0nsol3y 28 21 glycoconjugates glycoconjugate NNS cord-299038-e0nsol3y 28 22 , , , cord-299038-e0nsol3y 28 23 where where WRB cord-299038-e0nsol3y 28 24 it -PRON- PRP cord-299038-e0nsol3y 28 25 functions function VBZ cord-299038-e0nsol3y 28 26 in in IN cord-299038-e0nsol3y 28 27 recognition recognition NN cord-299038-e0nsol3y 28 28 and and CC cord-299038-e0nsol3y 28 29 anti anti JJ cord-299038-e0nsol3y 28 30 - - JJ cord-299038-e0nsol3y 28 31 recognition recognition JJ cord-299038-e0nsol3y 28 32 phenomena phenomenon NNS cord-299038-e0nsol3y 28 33 ranging range VBG cord-299038-e0nsol3y 28 34 from from IN cord-299038-e0nsol3y 28 35 the the DT cord-299038-e0nsol3y 28 36 regulation regulation NN cord-299038-e0nsol3y 28 37 of of IN cord-299038-e0nsol3y 28 38 complement complement JJ cord-299038-e0nsol3y 28 39 activation activation NN cord-299038-e0nsol3y 28 40 to to IN cord-299038-e0nsol3y 28 41 the the DT cord-299038-e0nsol3y 28 42 control control NN cord-299038-e0nsol3y 28 43 of of IN cord-299038-e0nsol3y 28 44 cell cell NN cord-299038-e0nsol3y 28 45 - - HYPH cord-299038-e0nsol3y 28 46 cell cell NN cord-299038-e0nsol3y 28 47 apposition apposition NN cord-299038-e0nsol3y 28 48 ( ( -LRB- cord-299038-e0nsol3y 28 49 Varki Varki NNP cord-299038-e0nsol3y 28 50 1993 1993 CD cord-299038-e0nsol3y 28 51 ) ) -RRB- cord-299038-e0nsol3y 28 52 . . . cord-299038-e0nsol3y 29 1 Like like IN cord-299038-e0nsol3y 29 2 their -PRON- PRP$ cord-299038-e0nsol3y 29 3 host host NN cord-299038-e0nsol3y 29 4 cells cell NNS cord-299038-e0nsol3y 29 5 , , , cord-299038-e0nsol3y 29 6 bacteria bacteria NNS cord-299038-e0nsol3y 29 7 have have VBP cord-299038-e0nsol3y 29 8 also also RB cord-299038-e0nsol3y 29 9 evolved evolve VBN cord-299038-e0nsol3y 29 10 complex complex JJ cord-299038-e0nsol3y 29 11 biosynthetic biosynthetic JJ cord-299038-e0nsol3y 29 12 pathways pathway NNS cord-299038-e0nsol3y 29 13 to to TO cord-299038-e0nsol3y 29 14 produce produce VB cord-299038-e0nsol3y 29 15 a a DT cord-299038-e0nsol3y 29 16 diverse diverse JJ cord-299038-e0nsol3y 29 17 array array NN cord-299038-e0nsol3y 29 18 of of IN cord-299038-e0nsol3y 29 19 carbohydrates carbohydrate NNS cord-299038-e0nsol3y 29 20 that that WDT cord-299038-e0nsol3y 29 21 form form VBP cord-299038-e0nsol3y 29 22 the the DT cord-299038-e0nsol3y 29 23 building building NN cord-299038-e0nsol3y 29 24 blocks block NNS cord-299038-e0nsol3y 29 25 of of IN cord-299038-e0nsol3y 29 26 capsular capsular JJ cord-299038-e0nsol3y 29 27 polysaccharides polysaccharide NNS cord-299038-e0nsol3y 29 28 ( ( -LRB- cord-299038-e0nsol3y 29 29 CPS CPS NNP cord-299038-e0nsol3y 29 30 ) ) -RRB- cord-299038-e0nsol3y 29 31 , , , cord-299038-e0nsol3y 29 32 lipopolysaccharides lipopolysaccharides NNP cord-299038-e0nsol3y 29 33 ( ( -LRB- cord-299038-e0nsol3y 29 34 LPS LPS NNP cord-299038-e0nsol3y 29 35 ) ) -RRB- cord-299038-e0nsol3y 29 36 , , , cord-299038-e0nsol3y 29 37 lipooligosaccharides lipooligosaccharides NNP cord-299038-e0nsol3y 29 38 ( ( -LRB- cord-299038-e0nsol3y 29 39 LOS LOS NNP cord-299038-e0nsol3y 29 40 ) ) -RRB- cord-299038-e0nsol3y 29 41 , , , cord-299038-e0nsol3y 29 42 and and CC cord-299038-e0nsol3y 29 43 peptidoglycans peptidoglycans NNP cord-299038-e0nsol3y 29 44 . . . cord-299038-e0nsol3y 30 1 These these DT cord-299038-e0nsol3y 30 2 specialized specialized JJ cord-299038-e0nsol3y 30 3 bacterial bacterial JJ cord-299038-e0nsol3y 30 4 glycans glycan NNS cord-299038-e0nsol3y 30 5 play play VBP cord-299038-e0nsol3y 30 6 pivotal pivotal JJ cord-299038-e0nsol3y 30 7 roles role NNS cord-299038-e0nsol3y 30 8 in in IN cord-299038-e0nsol3y 30 9 a a DT cord-299038-e0nsol3y 30 10 number number NN cord-299038-e0nsol3y 30 11 of of IN cord-299038-e0nsol3y 30 12 biological biological JJ cord-299038-e0nsol3y 30 13 processes process NNS cord-299038-e0nsol3y 30 14 , , , cord-299038-e0nsol3y 30 15 particularly particularly RB cord-299038-e0nsol3y 30 16 mediating mediate VBG cord-299038-e0nsol3y 30 17 microbe microbe NN cord-299038-e0nsol3y 30 18 - - HYPH cord-299038-e0nsol3y 30 19 host host NN cord-299038-e0nsol3y 30 20 interactions interaction NNS cord-299038-e0nsol3y 30 21 during during IN cord-299038-e0nsol3y 30 22 the the DT cord-299038-e0nsol3y 30 23 onset onset NN cord-299038-e0nsol3y 30 24 and and CC cord-299038-e0nsol3y 30 25 development development NN cord-299038-e0nsol3y 30 26 of of IN cord-299038-e0nsol3y 30 27 infectious infectious JJ cord-299038-e0nsol3y 30 28 disease disease NN cord-299038-e0nsol3y 30 29 . . . cord-299038-e0nsol3y 31 1 It -PRON- PRP cord-299038-e0nsol3y 31 2 has have VBZ cord-299038-e0nsol3y 31 3 been be VBN cord-299038-e0nsol3y 31 4 long long RB cord-299038-e0nsol3y 31 5 known know VBN cord-299038-e0nsol3y 31 6 that that IN cord-299038-e0nsol3y 31 7 the the DT cord-299038-e0nsol3y 31 8 bacterial bacterial JJ cord-299038-e0nsol3y 31 9 CPS CPS NNP cord-299038-e0nsol3y 31 10 represents represent VBZ cord-299038-e0nsol3y 31 11 a a DT cord-299038-e0nsol3y 31 12 key key JJ cord-299038-e0nsol3y 31 13 virulence virulence NN cord-299038-e0nsol3y 31 14 factor factor NN cord-299038-e0nsol3y 31 15 for for IN cord-299038-e0nsol3y 31 16 most most RBS cord-299038-e0nsol3y 31 17 encapsulated encapsulate VBN cord-299038-e0nsol3y 31 18 bacterial bacterial JJ cord-299038-e0nsol3y 31 19 pathogens pathogen NNS cord-299038-e0nsol3y 31 20 by by IN cord-299038-e0nsol3y 31 21 protecting protect VBG cord-299038-e0nsol3y 31 22 them -PRON- PRP cord-299038-e0nsol3y 31 23 from from IN cord-299038-e0nsol3y 31 24 immune immune JJ cord-299038-e0nsol3y 31 25 clearance clearance NN cord-299038-e0nsol3y 31 26 within within IN cord-299038-e0nsol3y 31 27 the the DT cord-299038-e0nsol3y 31 28 host host NN cord-299038-e0nsol3y 31 29 . . . cord-299038-e0nsol3y 32 1 Some some DT cord-299038-e0nsol3y 32 2 bacterial bacterial JJ cord-299038-e0nsol3y 32 3 capsules capsule NNS cord-299038-e0nsol3y 32 4 interfere interfere VBP cord-299038-e0nsol3y 32 5 with with IN cord-299038-e0nsol3y 32 6 the the DT cord-299038-e0nsol3y 32 7 binding binding NN cord-299038-e0nsol3y 32 8 and and CC cord-299038-e0nsol3y 32 9 activation activation NN cord-299038-e0nsol3y 32 10 of of IN cord-299038-e0nsol3y 32 11 complement complement JJ cord-299038-e0nsol3y 32 12 factors factor NNS cord-299038-e0nsol3y 32 13 on on IN cord-299038-e0nsol3y 32 14 the the DT cord-299038-e0nsol3y 32 15 bacterial bacterial JJ cord-299038-e0nsol3y 32 16 surface surface NN cord-299038-e0nsol3y 32 17 by by IN cord-299038-e0nsol3y 32 18 inhibiting inhibit VBG cord-299038-e0nsol3y 32 19 the the DT cord-299038-e0nsol3y 32 20 C3b C3b NNP cord-299038-e0nsol3y 32 21 convertase convertase NN cord-299038-e0nsol3y 32 22 or or CC cord-299038-e0nsol3y 32 23 recruiting recruit VBG cord-299038-e0nsol3y 32 24 inhibitory inhibitory JJ cord-299038-e0nsol3y 32 25 complement complement NN cord-299038-e0nsol3y 32 26 factor factor NN cord-299038-e0nsol3y 32 27 H H NNP cord-299038-e0nsol3y 32 28 ( ( -LRB- cord-299038-e0nsol3y 32 29 Cross Cross NNP cord-299038-e0nsol3y 32 30 and and CC cord-299038-e0nsol3y 32 31 Kelly Kelly NNP cord-299038-e0nsol3y 32 32 1990 1990 CD cord-299038-e0nsol3y 32 33 ) ) -RRB- cord-299038-e0nsol3y 32 34 . . . cord-299038-e0nsol3y 33 1 Bacterial bacterial JJ cord-299038-e0nsol3y 33 2 capsules capsule NNS cord-299038-e0nsol3y 33 3 exerting exert VBG cord-299038-e0nsol3y 33 4 this this DT cord-299038-e0nsol3y 33 5 immune immune JJ cord-299038-e0nsol3y 33 6 resistance resistance NN cord-299038-e0nsol3y 33 7 mechanism mechanism NN cord-299038-e0nsol3y 33 8 usually usually RB cord-299038-e0nsol3y 33 9 contain contain VBP cord-299038-e0nsol3y 33 10 sialic sialic JJ cord-299038-e0nsol3y 33 11 or or CC cord-299038-e0nsol3y 33 12 polysialic polysialic JJ cord-299038-e0nsol3y 33 13 acids acid NNS cord-299038-e0nsol3y 33 14 or or CC cord-299038-e0nsol3y 33 15 hyaluronic hyaluronic NN cord-299038-e0nsol3y 33 16 acid acid NN cord-299038-e0nsol3y 33 17 ( ( -LRB- cord-299038-e0nsol3y 33 18 HA HA NNP cord-299038-e0nsol3y 33 19 ) ) -RRB- cord-299038-e0nsol3y 33 20 , , , cord-299038-e0nsol3y 33 21 structurally structurally RB cord-299038-e0nsol3y 33 22 identical identical JJ cord-299038-e0nsol3y 33 23 or or CC cord-299038-e0nsol3y 33 24 similar similar JJ cord-299038-e0nsol3y 33 25 to to IN cord-299038-e0nsol3y 33 26 the the DT cord-299038-e0nsol3y 33 27 polysaccharides polysaccharide NNS cord-299038-e0nsol3y 33 28 found find VBN cord-299038-e0nsol3y 33 29 in in IN cord-299038-e0nsol3y 33 30 mammalian mammalian JJ cord-299038-e0nsol3y 33 31 tissues tissue NNS cord-299038-e0nsol3y 33 32 , , , cord-299038-e0nsol3y 33 33 as as IN cord-299038-e0nsol3y 33 34 exemplified exemplify VBN cord-299038-e0nsol3y 33 35 by by IN cord-299038-e0nsol3y 33 36 Escherichia Escherichia NNP cord-299038-e0nsol3y 33 37 coli coli VBZ cord-299038-e0nsol3y 33 38 K1 K1 NNP cord-299038-e0nsol3y 33 39 , , , cord-299038-e0nsol3y 33 40 Neisseria Neisseria NNP cord-299038-e0nsol3y 33 41 meningitidis meningitidis NN cord-299038-e0nsol3y 33 42 types type NNS cord-299038-e0nsol3y 33 43 B B NNP cord-299038-e0nsol3y 33 44 and and CC cord-299038-e0nsol3y 33 45 C C NNP cord-299038-e0nsol3y 33 46 , , , cord-299038-e0nsol3y 33 47 or or CC cord-299038-e0nsol3y 33 48 group group NN cord-299038-e0nsol3y 33 49 A a NN cord-299038-e0nsol3y 33 50 or or CC cord-299038-e0nsol3y 33 51 group group NN cord-299038-e0nsol3y 33 52 B B NNP cord-299038-e0nsol3y 33 53 Streptococcus streptococcus NN cord-299038-e0nsol3y 33 54 ( ( -LRB- cord-299038-e0nsol3y 33 55 Stevens Stevens NNP cord-299038-e0nsol3y 33 56 et et NNP cord-299038-e0nsol3y 33 57 al al NNP cord-299038-e0nsol3y 33 58 . . . cord-299038-e0nsol3y 33 59 1978 1978 CD cord-299038-e0nsol3y 33 60 ; ; : cord-299038-e0nsol3y 33 61 Wessels Wessels NNP cord-299038-e0nsol3y 33 62 et et NNP cord-299038-e0nsol3y 33 63 al al NNP cord-299038-e0nsol3y 33 64 . . . cord-299038-e0nsol3y 34 1 1989 1989 CD cord-299038-e0nsol3y 34 2 ; ; : cord-299038-e0nsol3y 34 3 Foley Foley NNP cord-299038-e0nsol3y 34 4 and and CC cord-299038-e0nsol3y 34 5 Wood Wood NNP cord-299038-e0nsol3y 34 6 1959 1959 CD cord-299038-e0nsol3y 34 7 ; ; : cord-299038-e0nsol3y 34 8 Dale Dale NNP cord-299038-e0nsol3y 34 9 et et NNP cord-299038-e0nsol3y 34 10 al al NNP cord-299038-e0nsol3y 34 11 . . . cord-299038-e0nsol3y 34 12 1996 1996 CD cord-299038-e0nsol3y 34 13 ) ) -RRB- cord-299038-e0nsol3y 34 14 . . . cord-299038-e0nsol3y 35 1 Envelopment Envelopment VBN cord-299038-e0nsol3y 35 2 in in IN cord-299038-e0nsol3y 35 3 these these DT cord-299038-e0nsol3y 35 4 host host NN cord-299038-e0nsol3y 35 5 - - HYPH cord-299038-e0nsol3y 35 6 like like JJ cord-299038-e0nsol3y 35 7 capsular capsular JJ cord-299038-e0nsol3y 35 8 structures structure NNS cord-299038-e0nsol3y 35 9 confers confer VBZ cord-299038-e0nsol3y 35 10 resistance resistance NN cord-299038-e0nsol3y 35 11 to to IN cord-299038-e0nsol3y 35 12 complement complement VB cord-299038-e0nsol3y 35 13 - - HYPH cord-299038-e0nsol3y 35 14 mediated mediate VBN cord-299038-e0nsol3y 35 15 killing killing NN cord-299038-e0nsol3y 35 16 and and CC cord-299038-e0nsol3y 35 17 phagocytic phagocytic JJ cord-299038-e0nsol3y 35 18 uptake uptake NN cord-299038-e0nsol3y 35 19 by by IN cord-299038-e0nsol3y 35 20 neutrophils neutrophil NNS cord-299038-e0nsol3y 35 21 and and CC cord-299038-e0nsol3y 35 22 macrophages macrophage NNS cord-299038-e0nsol3y 35 23 , , , cord-299038-e0nsol3y 35 24 increasing increase VBG cord-299038-e0nsol3y 35 25 the the DT cord-299038-e0nsol3y 35 26 chance chance NN cord-299038-e0nsol3y 35 27 of of IN cord-299038-e0nsol3y 35 28 bacterial bacterial JJ cord-299038-e0nsol3y 35 29 survival survival NN cord-299038-e0nsol3y 35 30 and and CC cord-299038-e0nsol3y 35 31 dissemination dissemination NN cord-299038-e0nsol3y 35 32 into into IN cord-299038-e0nsol3y 35 33 host host NN cord-299038-e0nsol3y 35 34 tissues tissue NNS cord-299038-e0nsol3y 35 35 . . . cord-299038-e0nsol3y 36 1 In in IN cord-299038-e0nsol3y 36 2 addition addition NN cord-299038-e0nsol3y 36 3 to to IN cord-299038-e0nsol3y 36 4 these these DT cord-299038-e0nsol3y 36 5 passive passive JJ cord-299038-e0nsol3y 36 6 mechanisms mechanism NNS cord-299038-e0nsol3y 36 7 of of IN cord-299038-e0nsol3y 36 8 protection protection NN cord-299038-e0nsol3y 36 9 , , , cord-299038-e0nsol3y 36 10 an an DT cord-299038-e0nsol3y 36 11 emerging emerge VBG cord-299038-e0nsol3y 36 12 hypothesis hypothesis NN cord-299038-e0nsol3y 36 13 has have VBZ cord-299038-e0nsol3y 36 14 been be VBN cord-299038-e0nsol3y 36 15 raised raise VBN cord-299038-e0nsol3y 36 16 based base VBN cord-299038-e0nsol3y 36 17 upon upon IN cord-299038-e0nsol3y 36 18 the the DT cord-299038-e0nsol3y 36 19 discovery discovery NN cord-299038-e0nsol3y 36 20 of of IN cord-299038-e0nsol3y 36 21 inhibitory inhibitory JJ cord-299038-e0nsol3y 36 22 members member NNS cord-299038-e0nsol3y 36 23 of of IN cord-299038-e0nsol3y 36 24 the the DT cord-299038-e0nsol3y 36 25 Siglec Siglec NNP cord-299038-e0nsol3y 36 26 protein protein NN cord-299038-e0nsol3y 36 27 family family NN cord-299038-e0nsol3y 36 28 on on IN cord-299038-e0nsol3y 36 29 immune immune JJ cord-299038-e0nsol3y 36 30 cells cell NNS cord-299038-e0nsol3y 36 31 . . . cord-299038-e0nsol3y 37 1 Researchers researcher NNS cord-299038-e0nsol3y 37 2 have have VBP cord-299038-e0nsol3y 37 3 explored explore VBN cord-299038-e0nsol3y 37 4 whether whether IN cord-299038-e0nsol3y 37 5 these these DT cord-299038-e0nsol3y 37 6 host host NN cord-299038-e0nsol3y 37 7 - - HYPH cord-299038-e0nsol3y 37 8 mimicking mimic VBG cord-299038-e0nsol3y 37 9 pathogens pathogen NNS cord-299038-e0nsol3y 37 10 can can MD cord-299038-e0nsol3y 37 11 blunt blunt VB cord-299038-e0nsol3y 37 12 activation activation NN cord-299038-e0nsol3y 37 13 of of IN cord-299038-e0nsol3y 37 14 antimicrobial antimicrobial JJ cord-299038-e0nsol3y 37 15 responses response NNS cord-299038-e0nsol3y 37 16 via via IN cord-299038-e0nsol3y 37 17 engagement engagement NN cord-299038-e0nsol3y 37 18 of of IN cord-299038-e0nsol3y 37 19 inhibitory inhibitory JJ cord-299038-e0nsol3y 37 20 Siglecs Siglecs NNP cord-299038-e0nsol3y 37 21 using use VBG cord-299038-e0nsol3y 37 22 the the DT cord-299038-e0nsol3y 37 23 Sia Sia NNP cord-299038-e0nsol3y 37 24 in in IN cord-299038-e0nsol3y 37 25 their -PRON- PRP$ cord-299038-e0nsol3y 37 26 CPS cp NNS cord-299038-e0nsol3y 37 27 . . . cord-299038-e0nsol3y 38 1 In in IN cord-299038-e0nsol3y 38 2 parallel parallel NN cord-299038-e0nsol3y 38 3 , , , cord-299038-e0nsol3y 38 4 studies study NNS cord-299038-e0nsol3y 38 5 have have VBP cord-299038-e0nsol3y 38 6 asked ask VBN cord-299038-e0nsol3y 38 7 how how WRB cord-299038-e0nsol3y 38 8 hosts host NNS cord-299038-e0nsol3y 38 9 have have VBP cord-299038-e0nsol3y 38 10 evolved evolve VBN cord-299038-e0nsol3y 38 11 to to TO cord-299038-e0nsol3y 38 12 better better RB cord-299038-e0nsol3y 38 13 recognize recognize VB cord-299038-e0nsol3y 38 14 and and CC cord-299038-e0nsol3y 38 15 destroy destroy VB cord-299038-e0nsol3y 38 16 such such JJ cord-299038-e0nsol3y 38 17 camouflaged camouflage VBN cord-299038-e0nsol3y 38 18 pathogens pathogen NNS cord-299038-e0nsol3y 38 19 . . . cord-299038-e0nsol3y 39 1 The the DT cord-299038-e0nsol3y 39 2 interplay interplay NN cord-299038-e0nsol3y 39 3 between between IN cord-299038-e0nsol3y 39 4 a a DT cord-299038-e0nsol3y 39 5 particular particular JJ cord-299038-e0nsol3y 39 6 sialylated sialylated JJ cord-299038-e0nsol3y 39 7 human human JJ cord-299038-e0nsol3y 39 8 pathogen pathogen NN cord-299038-e0nsol3y 39 9 , , , cord-299038-e0nsol3y 39 10 group group NN cord-299038-e0nsol3y 39 11 B B NNP cord-299038-e0nsol3y 39 12 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 39 13 ( ( -LRB- cord-299038-e0nsol3y 39 14 GBS GBS NNP cord-299038-e0nsol3y 39 15 ) ) -RRB- cord-299038-e0nsol3y 39 16 , , , cord-299038-e0nsol3y 39 17 and and CC cord-299038-e0nsol3y 39 18 host host NN cord-299038-e0nsol3y 39 19 immune immune JJ cord-299038-e0nsol3y 39 20 responses response NNS cord-299038-e0nsol3y 39 21 serves serve VBZ cord-299038-e0nsol3y 39 22 as as IN cord-299038-e0nsol3y 39 23 a a DT cord-299038-e0nsol3y 39 24 good good JJ cord-299038-e0nsol3y 39 25 first first JJ cord-299038-e0nsol3y 39 26 example example NN cord-299038-e0nsol3y 39 27 to to TO cord-299038-e0nsol3y 39 28 illustrate illustrate VB cord-299038-e0nsol3y 39 29 the the DT cord-299038-e0nsol3y 39 30 role role NN cord-299038-e0nsol3y 39 31 of of IN cord-299038-e0nsol3y 39 32 Siglecs Siglecs NNP cord-299038-e0nsol3y 39 33 and and CC cord-299038-e0nsol3y 39 34 bacterial bacterial JJ cord-299038-e0nsol3y 39 35 expression expression NN cord-299038-e0nsol3y 39 36 of of IN cord-299038-e0nsol3y 39 37 Sia Sia NNP cord-299038-e0nsol3y 39 38 in in IN cord-299038-e0nsol3y 39 39 the the DT cord-299038-e0nsol3y 39 40 pathogenesis pathogenesis NN cord-299038-e0nsol3y 39 41 of of IN cord-299038-e0nsol3y 39 42 infection infection NN cord-299038-e0nsol3y 39 43 . . . cord-299038-e0nsol3y 40 1 GBS GBS NNP cord-299038-e0nsol3y 40 2 is be VBZ cord-299038-e0nsol3y 40 3 a a DT cord-299038-e0nsol3y 40 4 leading leading JJ cord-299038-e0nsol3y 40 5 cause cause NN cord-299038-e0nsol3y 40 6 of of IN cord-299038-e0nsol3y 40 7 neonatal neonatal JJ cord-299038-e0nsol3y 40 8 pneumonia pneumonia NN cord-299038-e0nsol3y 40 9 , , , cord-299038-e0nsol3y 40 10 sepsis sepsis NN cord-299038-e0nsol3y 40 11 , , , cord-299038-e0nsol3y 40 12 and and CC cord-299038-e0nsol3y 40 13 meningitis meningitis NN cord-299038-e0nsol3y 40 14 and and CC cord-299038-e0nsol3y 40 15 is be VBZ cord-299038-e0nsol3y 40 16 increasingly increasingly RB cord-299038-e0nsol3y 40 17 recognized recognize VBN cord-299038-e0nsol3y 40 18 as as IN cord-299038-e0nsol3y 40 19 a a DT cord-299038-e0nsol3y 40 20 pathogen pathogen NN cord-299038-e0nsol3y 40 21 in in IN cord-299038-e0nsol3y 40 22 elderly elderly JJ cord-299038-e0nsol3y 40 23 and and CC cord-299038-e0nsol3y 40 24 immunocompromised immunocompromised JJ cord-299038-e0nsol3y 40 25 adult adult NN cord-299038-e0nsol3y 40 26 populations population NNS cord-299038-e0nsol3y 40 27 ( ( -LRB- cord-299038-e0nsol3y 40 28 Heath Heath NNP cord-299038-e0nsol3y 40 29 and and CC cord-299038-e0nsol3y 40 30 Schuchat Schuchat NNP cord-299038-e0nsol3y 40 31 2007 2007 CD cord-299038-e0nsol3y 40 32 ; ; : cord-299038-e0nsol3y 41 1 Thigpen Thigpen NNP cord-299038-e0nsol3y 41 2 et et FW cord-299038-e0nsol3y 41 3 al al NNP cord-299038-e0nsol3y 41 4 . . . cord-299038-e0nsol3y 42 1 2011 2011 CD cord-299038-e0nsol3y 42 2 ; ; : cord-299038-e0nsol3y 42 3 Skoff Skoff NNP cord-299038-e0nsol3y 42 4 et et NNP cord-299038-e0nsol3y 42 5 al al NNP cord-299038-e0nsol3y 42 6 . . NNP cord-299038-e0nsol3y 42 7 2009 2009 CD cord-299038-e0nsol3y 42 8 ) ) -RRB- cord-299038-e0nsol3y 42 9 . . . cord-299038-e0nsol3y 43 1 GBS GBS NNP cord-299038-e0nsol3y 43 2 can can MD cord-299038-e0nsol3y 43 3 be be VB cord-299038-e0nsol3y 43 4 classified classify VBN cord-299038-e0nsol3y 43 5 into into IN cord-299038-e0nsol3y 43 6 ten ten CD cord-299038-e0nsol3y 43 7 serotypes serotype NNS cord-299038-e0nsol3y 43 8 varying vary VBG cord-299038-e0nsol3y 43 9 in in IN cord-299038-e0nsol3y 43 10 structural structural JJ cord-299038-e0nsol3y 43 11 and and CC cord-299038-e0nsol3y 43 12 antigenic antigenic JJ cord-299038-e0nsol3y 43 13 features feature NNS cord-299038-e0nsol3y 43 14 , , , cord-299038-e0nsol3y 43 15 but but CC cord-299038-e0nsol3y 43 16 which which WDT cord-299038-e0nsol3y 43 17 share share VBP cord-299038-e0nsol3y 43 18 in in IN cord-299038-e0nsol3y 43 19 common common JJ cord-299038-e0nsol3y 43 20 the the DT cord-299038-e0nsol3y 43 21 presence presence NN cord-299038-e0nsol3y 43 22 of of IN cord-299038-e0nsol3y 43 23 a a DT cord-299038-e0nsol3y 43 24 terminal terminal JJ cord-299038-e0nsol3y 43 25 Sia Sia NNP cord-299038-e0nsol3y 43 26 residue residue NN cord-299038-e0nsol3y 43 27 that that WDT cord-299038-e0nsol3y 43 28 closely closely RB cord-299038-e0nsol3y 43 29 resembles resemble VBZ cord-299038-e0nsol3y 43 30 the the DT cord-299038-e0nsol3y 43 31 one one NN cord-299038-e0nsol3y 43 32 presented present VBN cord-299038-e0nsol3y 43 33 throughout throughout IN cord-299038-e0nsol3y 43 34 the the DT cord-299038-e0nsol3y 43 35 abundant abundant JJ cord-299038-e0nsol3y 43 36 surface surface NN cord-299038-e0nsol3y 43 37 glycocalyx glycocalyx NNP cord-299038-e0nsol3y 43 38 of of IN cord-299038-e0nsol3y 43 39 all all DT cord-299038-e0nsol3y 43 40 human human JJ cord-299038-e0nsol3y 43 41 cells cell NNS cord-299038-e0nsol3y 44 1 ( ( -LRB- cord-299038-e0nsol3y 44 2 Cieslewicz Cieslewicz NNP cord-299038-e0nsol3y 44 3 et et NNP cord-299038-e0nsol3y 44 4 al al NNP cord-299038-e0nsol3y 44 5 . . NNP cord-299038-e0nsol3y 44 6 2005 2005 CD cord-299038-e0nsol3y 44 7 ) ) -RRB- cord-299038-e0nsol3y 44 8 . . . cord-299038-e0nsol3y 45 1 Sialylated Sialylated NNP cord-299038-e0nsol3y 45 2 CPS CPS NNP cord-299038-e0nsol3y 45 3 from from IN cord-299038-e0nsol3y 45 4 different different JJ cord-299038-e0nsol3y 45 5 GBS GBS NNP cord-299038-e0nsol3y 45 6 serotypes serotype NNS cord-299038-e0nsol3y 45 7 interacts interact VBZ cord-299038-e0nsol3y 45 8 with with IN cord-299038-e0nsol3y 45 9 several several JJ cord-299038-e0nsol3y 45 10 human human JJ cord-299038-e0nsol3y 45 11 Siglecs Siglecs NNP cord-299038-e0nsol3y 45 12 in in IN cord-299038-e0nsol3y 45 13 a a DT cord-299038-e0nsol3y 45 14 Sia Sia NNP cord-299038-e0nsol3y 45 15 - - HYPH cord-299038-e0nsol3y 45 16 and and CC cord-299038-e0nsol3y 45 17 serotype serotype NN cord-299038-e0nsol3y 45 18 - - HYPH cord-299038-e0nsol3y 45 19 specific specific JJ cord-299038-e0nsol3y 45 20 manner manner NN cord-299038-e0nsol3y 46 1 ( ( -LRB- cord-299038-e0nsol3y 46 2 Carlin Carlin NNP cord-299038-e0nsol3y 46 3 et et NNP cord-299038-e0nsol3y 46 4 al al NNP cord-299038-e0nsol3y 46 5 . . NNP cord-299038-e0nsol3y 46 6 2007 2007 CD cord-299038-e0nsol3y 46 7 ) ) -RRB- cord-299038-e0nsol3y 46 8 . . . cord-299038-e0nsol3y 47 1 Through through IN cord-299038-e0nsol3y 47 2 this this DT cord-299038-e0nsol3y 47 3 Sia Sia NNP cord-299038-e0nsol3y 47 4 molecular molecular JJ cord-299038-e0nsol3y 47 5 mimicry mimicry NN cord-299038-e0nsol3y 47 6 , , , cord-299038-e0nsol3y 47 7 GBS GBS NNP cord-299038-e0nsol3y 47 8 engages engage VBZ cord-299038-e0nsol3y 47 9 inhibitory inhibitory JJ cord-299038-e0nsol3y 47 10 human human JJ cord-299038-e0nsol3y 47 11 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 47 12 receptors receptor NNS cord-299038-e0nsol3y 47 13 on on IN cord-299038-e0nsol3y 47 14 neutrophils neutrophil NNS cord-299038-e0nsol3y 47 15 , , , cord-299038-e0nsol3y 47 16 resulting result VBG cord-299038-e0nsol3y 47 17 in in IN cord-299038-e0nsol3y 47 18 reduced reduce VBN cord-299038-e0nsol3y 47 19 production production NN cord-299038-e0nsol3y 47 20 of of IN cord-299038-e0nsol3y 47 21 reactive reactive JJ cord-299038-e0nsol3y 47 22 oxidative oxidative JJ cord-299038-e0nsol3y 47 23 species specie NNS cord-299038-e0nsol3y 47 24 ( ( -LRB- cord-299038-e0nsol3y 47 25 ROS ROS NNP cord-299038-e0nsol3y 47 26 ) ) -RRB- cord-299038-e0nsol3y 47 27 and and CC cord-299038-e0nsol3y 47 28 neutrophil neutrophil NN cord-299038-e0nsol3y 47 29 extracellular extracellular JJ cord-299038-e0nsol3y 47 30 traps trap NNS cord-299038-e0nsol3y 47 31 ( ( -LRB- cord-299038-e0nsol3y 47 32 NETs NETs NNP cord-299038-e0nsol3y 47 33 ) ) -RRB- cord-299038-e0nsol3y 47 34 , , , cord-299038-e0nsol3y 47 35 which which WDT cord-299038-e0nsol3y 47 36 together together RB cord-299038-e0nsol3y 47 37 impair impair VBP cord-299038-e0nsol3y 47 38 bactericidal bactericidal JJ cord-299038-e0nsol3y 47 39 activity activity NN cord-299038-e0nsol3y 47 40 ( ( -LRB- cord-299038-e0nsol3y 47 41 Carlin Carlin NNP cord-299038-e0nsol3y 47 42 et et NNP cord-299038-e0nsol3y 47 43 al al NNP cord-299038-e0nsol3y 47 44 . . NNP cord-299038-e0nsol3y 47 45 2009b 2009b CD cord-299038-e0nsol3y 47 46 ) ) -RRB- cord-299038-e0nsol3y 47 47 . . . cord-299038-e0nsol3y 48 1 Recently recently RB cord-299038-e0nsol3y 48 2 , , , cord-299038-e0nsol3y 48 3 GBS GBS NNP cord-299038-e0nsol3y 48 4 Sia Sia NNP cord-299038-e0nsol3y 48 5 engagement engagement NN cord-299038-e0nsol3y 48 6 of of IN cord-299038-e0nsol3y 48 7 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 48 8 on on IN cord-299038-e0nsol3y 48 9 human human JJ cord-299038-e0nsol3y 48 10 platelets platelet NNS cord-299038-e0nsol3y 48 11 to to TO cord-299038-e0nsol3y 48 12 suppress suppress VB cord-299038-e0nsol3y 48 13 their -PRON- PRP$ cord-299038-e0nsol3y 48 14 activation activation NN cord-299038-e0nsol3y 48 15 and and CC cord-299038-e0nsol3y 48 16 release release NN cord-299038-e0nsol3y 48 17 of of IN cord-299038-e0nsol3y 48 18 antimicrobial antimicrobial JJ cord-299038-e0nsol3y 48 19 peptides peptide NNS cord-299038-e0nsol3y 48 20 ( ( -LRB- cord-299038-e0nsol3y 48 21 AMPs amp NNS cord-299038-e0nsol3y 48 22 ) ) -RRB- cord-299038-e0nsol3y 48 23 was be VBD cord-299038-e0nsol3y 48 24 shown show VBN cord-299038-e0nsol3y 48 25 to to TO cord-299038-e0nsol3y 48 26 contribute contribute VB cord-299038-e0nsol3y 48 27 to to IN cord-299038-e0nsol3y 48 28 GBS GBS NNP cord-299038-e0nsol3y 48 29 resistance resistance NN cord-299038-e0nsol3y 48 30 to to IN cord-299038-e0nsol3y 48 31 platelet platelet NN cord-299038-e0nsol3y 48 32 killing killing NN cord-299038-e0nsol3y 48 33 ( ( -LRB- cord-299038-e0nsol3y 48 34 Uchiyama Uchiyama NNP cord-299038-e0nsol3y 48 35 et et NNP cord-299038-e0nsol3y 48 36 al al NNP cord-299038-e0nsol3y 48 37 . . . cord-299038-e0nsol3y 48 38 2019 2019 CD cord-299038-e0nsol3y 48 39 ) ) -RRB- cord-299038-e0nsol3y 48 40 . . . cord-299038-e0nsol3y 49 1 Corroborating corroborate VBG cord-299038-e0nsol3y 49 2 these these DT cord-299038-e0nsol3y 49 3 findings finding NNS cord-299038-e0nsol3y 49 4 , , , cord-299038-e0nsol3y 49 5 transgenic transgenic JJ cord-299038-e0nsol3y 49 6 mice mouse NNS cord-299038-e0nsol3y 49 7 expressing express VBG cord-299038-e0nsol3y 49 8 a a DT cord-299038-e0nsol3y 49 9 soluble soluble JJ cord-299038-e0nsol3y 49 10 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 49 11 receptor receptor NN cord-299038-e0nsol3y 49 12 , , , cord-299038-e0nsol3y 49 13 which which WDT cord-299038-e0nsol3y 49 14 acts act VBZ cord-299038-e0nsol3y 49 15 as as IN cord-299038-e0nsol3y 49 16 a a DT cord-299038-e0nsol3y 49 17 decoy decoy NN cord-299038-e0nsol3y 49 18 to to TO cord-299038-e0nsol3y 49 19 prevent prevent VB cord-299038-e0nsol3y 49 20 neutrophil neutrophil NN cord-299038-e0nsol3y 49 21 suppression suppression NN cord-299038-e0nsol3y 49 22 , , , cord-299038-e0nsol3y 49 23 were be VBD cord-299038-e0nsol3y 49 24 more more RBR cord-299038-e0nsol3y 49 25 resistant resistant JJ cord-299038-e0nsol3y 49 26 to to IN cord-299038-e0nsol3y 49 27 GBS GBS NNP cord-299038-e0nsol3y 49 28 infection infection NN cord-299038-e0nsol3y 49 29 in in IN cord-299038-e0nsol3y 49 30 vivo vivo NN cord-299038-e0nsol3y 50 1 ( ( -LRB- cord-299038-e0nsol3y 50 2 Saito Saito NNP cord-299038-e0nsol3y 50 3 et et NNP cord-299038-e0nsol3y 50 4 al al NNP cord-299038-e0nsol3y 50 5 . . . cord-299038-e0nsol3y 50 6 2016 2016 CD cord-299038-e0nsol3y 50 7 ) ) -RRB- cord-299038-e0nsol3y 50 8 . . . cord-299038-e0nsol3y 51 1 Linkages linkage NNS cord-299038-e0nsol3y 51 2 to to IN cord-299038-e0nsol3y 51 3 the the DT cord-299038-e0nsol3y 51 4 underlying underlying JJ cord-299038-e0nsol3y 51 5 sugar sugar NN cord-299038-e0nsol3y 51 6 chain chain NN cord-299038-e0nsol3y 51 7 as as RB cord-299038-e0nsol3y 51 8 well well RB cord-299038-e0nsol3y 51 9 as as IN cord-299038-e0nsol3y 51 10 the the DT cord-299038-e0nsol3y 51 11 substitution substitution NN cord-299038-e0nsol3y 51 12 at at IN cord-299038-e0nsol3y 51 13 certain certain JJ cord-299038-e0nsol3y 51 14 carbon carbon NN cord-299038-e0nsol3y 51 15 positions position NNS cord-299038-e0nsol3y 51 16 of of IN cord-299038-e0nsol3y 51 17 Sias Sias NNP cord-299038-e0nsol3y 51 18 are be VBP cord-299038-e0nsol3y 51 19 critical critical JJ cord-299038-e0nsol3y 51 20 in in IN cord-299038-e0nsol3y 51 21 determining determine VBG cord-299038-e0nsol3y 51 22 their -PRON- PRP$ cord-299038-e0nsol3y 51 23 binding bind VBG cord-299038-e0nsol3y 51 24 specificity specificity NN cord-299038-e0nsol3y 51 25 for for IN cord-299038-e0nsol3y 51 26 Siglecs Siglecs NNP cord-299038-e0nsol3y 51 27 . . . cord-299038-e0nsol3y 52 1 One one CD cord-299038-e0nsol3y 52 2 study study NN cord-299038-e0nsol3y 52 3 used use VBD cord-299038-e0nsol3y 52 4 isogenic isogenic JJ cord-299038-e0nsol3y 52 5 mutants mutant NNS cord-299038-e0nsol3y 52 6 with with IN cord-299038-e0nsol3y 52 7 different different JJ cord-299038-e0nsol3y 52 8 O o NN cord-299038-e0nsol3y 52 9 - - HYPH cord-299038-e0nsol3y 52 10 acetylation acetylation NN cord-299038-e0nsol3y 52 11 phenotypes phenotype NNS cord-299038-e0nsol3y 52 12 to to TO cord-299038-e0nsol3y 52 13 show show VB cord-299038-e0nsol3y 52 14 that that IN cord-299038-e0nsol3y 52 15 Sia Sia NNP cord-299038-e0nsol3y 52 16 O o NN cord-299038-e0nsol3y 52 17 - - HYPH cord-299038-e0nsol3y 52 18 acetylation acetylation NN cord-299038-e0nsol3y 52 19 protects protect VBZ cord-299038-e0nsol3y 52 20 GBS GBS NNP cord-299038-e0nsol3y 52 21 CPS CPS NNP cord-299038-e0nsol3y 52 22 from from IN cord-299038-e0nsol3y 52 23 enzymatic enzymatic JJ cord-299038-e0nsol3y 52 24 removal removal NN cord-299038-e0nsol3y 52 25 by by IN cord-299038-e0nsol3y 52 26 microbial microbial JJ cord-299038-e0nsol3y 52 27 sialidases sialidase NNS cord-299038-e0nsol3y 52 28 produced produce VBN cord-299038-e0nsol3y 52 29 by by IN cord-299038-e0nsol3y 52 30 commensal commensal JJ cord-299038-e0nsol3y 52 31 microbes microbe NNS cord-299038-e0nsol3y 52 32 occupying occupy VBG cord-299038-e0nsol3y 52 33 in in IN cord-299038-e0nsol3y 52 34 the the DT cord-299038-e0nsol3y 52 35 same same JJ cord-299038-e0nsol3y 52 36 mucosal mucosal JJ cord-299038-e0nsol3y 52 37 niche niche NN cord-299038-e0nsol3y 52 38 as as IN cord-299038-e0nsol3y 52 39 GBS GBS NNP cord-299038-e0nsol3y 52 40 ( ( -LRB- cord-299038-e0nsol3y 52 41 Weiman Weiman NNP cord-299038-e0nsol3y 52 42 et et NNP cord-299038-e0nsol3y 52 43 al al NNP cord-299038-e0nsol3y 52 44 . . NNP cord-299038-e0nsol3y 52 45 2009 2009 CD cord-299038-e0nsol3y 52 46 ) ) -RRB- cord-299038-e0nsol3y 52 47 . . . cord-299038-e0nsol3y 53 1 However however RB cord-299038-e0nsol3y 53 2 , , , cord-299038-e0nsol3y 53 3 the the DT cord-299038-e0nsol3y 53 4 same same JJ cord-299038-e0nsol3y 53 5 modification modification NN cord-299038-e0nsol3y 53 6 markedly markedly RB cord-299038-e0nsol3y 53 7 reduced reduce VBN cord-299038-e0nsol3y 53 8 GBS GBS NNP cord-299038-e0nsol3y 53 9 binding bind VBG cord-299038-e0nsol3y 53 10 to to IN cord-299038-e0nsol3y 53 11 human human JJ cord-299038-e0nsol3y 53 12 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 53 13 , , , cord-299038-e0nsol3y 53 14 such such JJ cord-299038-e0nsol3y 53 15 that that IN cord-299038-e0nsol3y 53 16 highly highly RB cord-299038-e0nsol3y 53 17 O o NN cord-299038-e0nsol3y 53 18 - - HYPH cord-299038-e0nsol3y 53 19 acetylated acetylated JJ cord-299038-e0nsol3y 53 20 GBS GBS NNP cord-299038-e0nsol3y 53 21 mutants mutant NNS cord-299038-e0nsol3y 53 22 were be VBD cord-299038-e0nsol3y 53 23 less less RBR cord-299038-e0nsol3y 53 24 able able JJ cord-299038-e0nsol3y 53 25 to to TO cord-299038-e0nsol3y 53 26 accomplish accomplish VB cord-299038-e0nsol3y 53 27 Sia Sia NNP cord-299038-e0nsol3y 53 28 - - HYPH cord-299038-e0nsol3y 53 29 mediated mediate VBN cord-299038-e0nsol3y 53 30 neutrophil neutrophil NN cord-299038-e0nsol3y 53 31 suppression suppression NN cord-299038-e0nsol3y 53 32 and and CC cord-299038-e0nsol3y 53 33 showed show VBD cord-299038-e0nsol3y 53 34 reduced reduced JJ cord-299038-e0nsol3y 53 35 virulence virulence NN cord-299038-e0nsol3y 53 36 in in IN cord-299038-e0nsol3y 53 37 vivo vivo NN cord-299038-e0nsol3y 54 1 ( ( -LRB- cord-299038-e0nsol3y 54 2 Weiman Weiman NNP cord-299038-e0nsol3y 54 3 et et NNP cord-299038-e0nsol3y 54 4 al al NNP cord-299038-e0nsol3y 54 5 . . . cord-299038-e0nsol3y 54 6 2009 2009 CD cord-299038-e0nsol3y 55 1 ( ( -LRB- cord-299038-e0nsol3y 55 2 Weiman Weiman NNP cord-299038-e0nsol3y 55 3 et et NNP cord-299038-e0nsol3y 55 4 al al NNP cord-299038-e0nsol3y 55 5 . . NNP cord-299038-e0nsol3y 55 6 , , , cord-299038-e0nsol3y 55 7 2010 2010 CD cord-299038-e0nsol3y 55 8 . . . cord-299038-e0nsol3y 56 1 These these DT cord-299038-e0nsol3y 56 2 observations observation NNS cord-299038-e0nsol3y 56 3 suggest suggest VBP cord-299038-e0nsol3y 56 4 that that IN cord-299038-e0nsol3y 56 5 GBS GBS NNP cord-299038-e0nsol3y 56 6 must must MD cord-299038-e0nsol3y 56 7 balance balance VB cord-299038-e0nsol3y 56 8 competing compete VBG cord-299038-e0nsol3y 56 9 evolutionary evolutionary JJ cord-299038-e0nsol3y 56 10 selective selective JJ cord-299038-e0nsol3y 56 11 pressures pressure NNS cord-299038-e0nsol3y 56 12 to to TO cord-299038-e0nsol3y 56 13 fine fine VB cord-299038-e0nsol3y 56 14 tune tune VB cord-299038-e0nsol3y 56 15 the the DT cord-299038-e0nsol3y 56 16 O o NN cord-299038-e0nsol3y 56 17 - - HYPH cord-299038-e0nsol3y 56 18 acetylation acetylation NN cord-299038-e0nsol3y 56 19 level level NN cord-299038-e0nsol3y 56 20 of of IN cord-299038-e0nsol3y 56 21 CPS CPS NNP cord-299038-e0nsol3y 56 22 Sias Sias NNP cord-299038-e0nsol3y 56 23 to to TO cord-299038-e0nsol3y 56 24 maximize maximize VB cord-299038-e0nsol3y 56 25 its -PRON- PRP$ cord-299038-e0nsol3y 56 26 survival survival NN cord-299038-e0nsol3y 56 27 advantage advantage NN cord-299038-e0nsol3y 56 28 in in IN cord-299038-e0nsol3y 56 29 the the DT cord-299038-e0nsol3y 56 30 host host NN cord-299038-e0nsol3y 56 31 . . . cord-299038-e0nsol3y 57 1 The the DT cord-299038-e0nsol3y 57 2 role role NN cord-299038-e0nsol3y 57 3 of of IN cord-299038-e0nsol3y 57 4 GBS GBS NNP cord-299038-e0nsol3y 57 5 CPS CPS NNP cord-299038-e0nsol3y 57 6 Sia Sia NNP cord-299038-e0nsol3y 57 7 engagement engagement NN cord-299038-e0nsol3y 57 8 of of IN cord-299038-e0nsol3y 57 9 inhibitory inhibitory JJ cord-299038-e0nsol3y 57 10 Siglecs Siglecs NNP cord-299038-e0nsol3y 57 11 in in IN cord-299038-e0nsol3y 57 12 the the DT cord-299038-e0nsol3y 57 13 context context NN cord-299038-e0nsol3y 57 14 of of IN cord-299038-e0nsol3y 57 15 in in IN cord-299038-e0nsol3y 57 16 vivo vivo NN cord-299038-e0nsol3y 57 17 infection infection NN cord-299038-e0nsol3y 57 18 was be VBD cord-299038-e0nsol3y 57 19 first first RB cord-299038-e0nsol3y 57 20 addressed address VBN cord-299038-e0nsol3y 57 21 in in IN cord-299038-e0nsol3y 57 22 Siglec Siglec NNP cord-299038-e0nsol3y 57 23 - - HYPH cord-299038-e0nsol3y 57 24 E E NNP cord-299038-e0nsol3y 57 25 deficient deficient JJ cord-299038-e0nsol3y 57 26 mice mouse NNS cord-299038-e0nsol3y 57 27 due due JJ cord-299038-e0nsol3y 57 28 to to IN cord-299038-e0nsol3y 57 29 the the DT cord-299038-e0nsol3y 57 30 similarity similarity NN cord-299038-e0nsol3y 57 31 of of IN cord-299038-e0nsol3y 57 32 function function NN cord-299038-e0nsol3y 57 33 and and CC cord-299038-e0nsol3y 57 34 cellular cellular JJ cord-299038-e0nsol3y 57 35 distribution distribution NN cord-299038-e0nsol3y 57 36 between between IN cord-299038-e0nsol3y 57 37 human human NN cord-299038-e0nsol3y 57 38 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 57 39 and and CC cord-299038-e0nsol3y 57 40 murine murine JJ cord-299038-e0nsol3y 57 41 Siglec Siglec NNP cord-299038-e0nsol3y 57 42 - - HYPH cord-299038-e0nsol3y 57 43 E. E. NNP cord-299038-e0nsol3y 57 44 Upon upon IN cord-299038-e0nsol3y 57 45 lower low JJR cord-299038-e0nsol3y 57 46 dose dose NN cord-299038-e0nsol3y 57 47 GBS GBS NNP cord-299038-e0nsol3y 57 48 challenge challenge NN cord-299038-e0nsol3y 57 49 intranasally intranasally RB cord-299038-e0nsol3y 57 50 or or CC cord-299038-e0nsol3y 57 51 intravenously intravenously RB cord-299038-e0nsol3y 57 52 , , , cord-299038-e0nsol3y 57 53 Siglec Siglec NNP cord-299038-e0nsol3y 57 54 - - HYPH cord-299038-e0nsol3y 57 55 E E NNP cord-299038-e0nsol3y 57 56 deficient deficient JJ cord-299038-e0nsol3y 57 57 mice mouse NNS cord-299038-e0nsol3y 57 58 showed show VBD cord-299038-e0nsol3y 57 59 increased increased JJ cord-299038-e0nsol3y 57 60 production production NN cord-299038-e0nsol3y 57 61 of of IN cord-299038-e0nsol3y 57 62 several several JJ cord-299038-e0nsol3y 57 63 inflammatory inflammatory JJ cord-299038-e0nsol3y 57 64 cytokines cytokine NNS cord-299038-e0nsol3y 57 65 and and CC cord-299038-e0nsol3y 57 66 had have VBD cord-299038-e0nsol3y 57 67 reduced reduce VBN cord-299038-e0nsol3y 57 68 dissemination dissemination NN cord-299038-e0nsol3y 57 69 of of IN cord-299038-e0nsol3y 57 70 the the DT cord-299038-e0nsol3y 57 71 pathogen pathogen NN cord-299038-e0nsol3y 57 72 to to IN cord-299038-e0nsol3y 57 73 the the DT cord-299038-e0nsol3y 57 74 brain brain NN cord-299038-e0nsol3y 57 75 ( ( -LRB- cord-299038-e0nsol3y 57 76 GBS GBS NNP cord-299038-e0nsol3y 57 77 meningitis meningitis NN cord-299038-e0nsol3y 57 78 ) ) -RRB- cord-299038-e0nsol3y 57 79 . . . cord-299038-e0nsol3y 58 1 However however RB cord-299038-e0nsol3y 58 2 , , , cord-299038-e0nsol3y 58 3 exaggerated exaggerated JJ cord-299038-e0nsol3y 58 4 inflammatory inflammatory JJ cord-299038-e0nsol3y 58 5 mediators mediator NNS cord-299038-e0nsol3y 58 6 and and CC cord-299038-e0nsol3y 58 7 reduced reduce VBN cord-299038-e0nsol3y 58 8 anti anti JJ cord-299038-e0nsol3y 58 9 - - JJ cord-299038-e0nsol3y 58 10 inflammatory inflammatory JJ cord-299038-e0nsol3y 58 11 cytokine cytokine NN cord-299038-e0nsol3y 58 12 IL-10 IL-10 NNP cord-299038-e0nsol3y 58 13 production production NN cord-299038-e0nsol3y 58 14 were be VBD cord-299038-e0nsol3y 58 15 observed observe VBN cord-299038-e0nsol3y 58 16 in in IN cord-299038-e0nsol3y 58 17 the the DT cord-299038-e0nsol3y 58 18 Siglec Siglec NNP cord-299038-e0nsol3y 58 19 - - HYPH cord-299038-e0nsol3y 58 20 E E NNP cord-299038-e0nsol3y 58 21 deficient deficient JJ cord-299038-e0nsol3y 58 22 mice mouse NNS cord-299038-e0nsol3y 58 23 during during IN cord-299038-e0nsol3y 58 24 a a DT cord-299038-e0nsol3y 58 25 high high JJ cord-299038-e0nsol3y 58 26 - - HYPH cord-299038-e0nsol3y 58 27 dose dose NN cord-299038-e0nsol3y 58 28 lethal lethal JJ cord-299038-e0nsol3y 58 29 challenge challenge NN cord-299038-e0nsol3y 58 30 with with IN cord-299038-e0nsol3y 58 31 GBS GBS NNP cord-299038-e0nsol3y 59 1 ( ( -LRB- cord-299038-e0nsol3y 59 2 Chang Chang NNP cord-299038-e0nsol3y 59 3 et et NNP cord-299038-e0nsol3y 59 4 al al NNP cord-299038-e0nsol3y 59 5 . . NNP cord-299038-e0nsol3y 59 6 2014a 2014a CD cord-299038-e0nsol3y 59 7 ) ) -RRB- cord-299038-e0nsol3y 59 8 . . . cord-299038-e0nsol3y 60 1 Thus thus RB cord-299038-e0nsol3y 60 2 , , , cord-299038-e0nsol3y 60 3 the the DT cord-299038-e0nsol3y 60 4 sum sum NN cord-299038-e0nsol3y 60 5 consequence consequence NN cord-299038-e0nsol3y 60 6 of of IN cord-299038-e0nsol3y 60 7 the the DT cord-299038-e0nsol3y 60 8 GBS GBS NNP cord-299038-e0nsol3y 60 9 molecular molecular JJ cord-299038-e0nsol3y 60 10 mimicry mimicry NN cord-299038-e0nsol3y 60 11 and and CC cord-299038-e0nsol3y 60 12 inhibitory inhibitory JJ cord-299038-e0nsol3y 60 13 Siglec Siglec NNP cord-299038-e0nsol3y 60 14 engagement engagement NN cord-299038-e0nsol3y 60 15 is be VBZ cord-299038-e0nsol3y 60 16 likely likely JJ cord-299038-e0nsol3y 60 17 to to TO cord-299038-e0nsol3y 60 18 vary vary VB cord-299038-e0nsol3y 60 19 based base VBN cord-299038-e0nsol3y 60 20 upon upon IN cord-299038-e0nsol3y 60 21 the the DT cord-299038-e0nsol3y 60 22 site site NN cord-299038-e0nsol3y 60 23 , , , cord-299038-e0nsol3y 60 24 stage stage NN cord-299038-e0nsol3y 60 25 , , , cord-299038-e0nsol3y 60 26 and and CC cord-299038-e0nsol3y 60 27 magnitude magnitude NN cord-299038-e0nsol3y 60 28 of of IN cord-299038-e0nsol3y 60 29 infection infection NN cord-299038-e0nsol3y 60 30 . . . cord-299038-e0nsol3y 61 1 Importantly importantly RB cord-299038-e0nsol3y 61 2 , , , cord-299038-e0nsol3y 61 3 in in IN cord-299038-e0nsol3y 61 4 addition addition NN cord-299038-e0nsol3y 61 5 to to IN cord-299038-e0nsol3y 61 6 Sia Sia NNP cord-299038-e0nsol3y 61 7 - - HYPH cord-299038-e0nsol3y 61 8 dependent dependent JJ cord-299038-e0nsol3y 61 9 Siglec Siglec NNP cord-299038-e0nsol3y 61 10 engagement engagement NN cord-299038-e0nsol3y 61 11 , , , cord-299038-e0nsol3y 61 12 certain certain JJ cord-299038-e0nsol3y 61 13 GBS GBS NNP cord-299038-e0nsol3y 61 14 strains strain NNS cord-299038-e0nsol3y 61 15 can can MD cord-299038-e0nsol3y 61 16 use use VB cord-299038-e0nsol3y 61 17 the the DT cord-299038-e0nsol3y 61 18 surface surface NN cord-299038-e0nsol3y 61 19 - - HYPH cord-299038-e0nsol3y 61 20 anchored anchor VBN cord-299038-e0nsol3y 61 21 β β NN cord-299038-e0nsol3y 61 22 protein protein NN cord-299038-e0nsol3y 61 23 to to TO cord-299038-e0nsol3y 61 24 bind bind VB cord-299038-e0nsol3y 61 25 human human JJ cord-299038-e0nsol3y 61 26 Siglec-5 Siglec-5 NNPS cord-299038-e0nsol3y 61 27 , , , cord-299038-e0nsol3y 61 28 another another DT cord-299038-e0nsol3y 61 29 inhibitory inhibitory JJ cord-299038-e0nsol3y 61 30 Siglec Siglec NNP cord-299038-e0nsol3y 61 31 preferentially preferentially RB cord-299038-e0nsol3y 61 32 expressed express VBD cord-299038-e0nsol3y 61 33 on on IN cord-299038-e0nsol3y 61 34 macrophages macrophage NNS cord-299038-e0nsol3y 61 35 and and CC cord-299038-e0nsol3y 61 36 neutrophils neutrophil NNS cord-299038-e0nsol3y 61 37 . . . cord-299038-e0nsol3y 62 1 This this DT cord-299038-e0nsol3y 62 2 protein protein NN cord-299038-e0nsol3y 62 3 - - HYPH cord-299038-e0nsol3y 62 4 mediated mediate VBN cord-299038-e0nsol3y 62 5 engagement engagement NN cord-299038-e0nsol3y 62 6 increased increase VBD cord-299038-e0nsol3y 62 7 bacterial bacterial JJ cord-299038-e0nsol3y 62 8 attachment attachment NN cord-299038-e0nsol3y 62 9 to to IN cord-299038-e0nsol3y 62 10 the the DT cord-299038-e0nsol3y 62 11 macrophage macrophage NN cord-299038-e0nsol3y 62 12 surface surface NN cord-299038-e0nsol3y 62 13 , , , cord-299038-e0nsol3y 62 14 but but CC cord-299038-e0nsol3y 62 15 simultaneously simultaneously RB cord-299038-e0nsol3y 62 16 paralyzed paralyzed JJ cord-299038-e0nsol3y 62 17 macrophage macrophage NN cord-299038-e0nsol3y 62 18 killing killing NN cord-299038-e0nsol3y 62 19 functions function NNS cord-299038-e0nsol3y 62 20 , , , cord-299038-e0nsol3y 62 21 leading lead VBG cord-299038-e0nsol3y 62 22 to to IN cord-299038-e0nsol3y 62 23 a a DT cord-299038-e0nsol3y 62 24 net net JJ cord-299038-e0nsol3y 62 25 reduction reduction NN cord-299038-e0nsol3y 62 26 of of IN cord-299038-e0nsol3y 62 27 phagocytosis phagocytosis NN cord-299038-e0nsol3y 62 28 , , , cord-299038-e0nsol3y 62 29 ROS ROS NNP cord-299038-e0nsol3y 62 30 production production NN cord-299038-e0nsol3y 62 31 , , , cord-299038-e0nsol3y 62 32 NET net NN cord-299038-e0nsol3y 62 33 formation formation NN cord-299038-e0nsol3y 62 34 , , , cord-299038-e0nsol3y 62 35 and and CC cord-299038-e0nsol3y 62 36 bactericidal bactericidal JJ cord-299038-e0nsol3y 62 37 activity activity NN cord-299038-e0nsol3y 63 1 ( ( -LRB- cord-299038-e0nsol3y 63 2 Carlin Carlin NNP cord-299038-e0nsol3y 63 3 et et NNP cord-299038-e0nsol3y 63 4 al al NNP cord-299038-e0nsol3y 63 5 . . NNP cord-299038-e0nsol3y 63 6 2009a 2009a CD cord-299038-e0nsol3y 63 7 ) ) -RRB- cord-299038-e0nsol3y 63 8 . . . cord-299038-e0nsol3y 64 1 To to TO cord-299038-e0nsol3y 64 2 counteract counteract VB cord-299038-e0nsol3y 64 3 inhibitory inhibitory JJ cord-299038-e0nsol3y 64 4 Siglec Siglec NNP cord-299038-e0nsol3y 64 5 hijacking hijacking NN cord-299038-e0nsol3y 64 6 strategies strategy NNS cord-299038-e0nsol3y 64 7 of of IN cord-299038-e0nsol3y 64 8 bacterial bacterial JJ cord-299038-e0nsol3y 64 9 pathogens pathogen NNS cord-299038-e0nsol3y 64 10 , , , cord-299038-e0nsol3y 64 11 host host NN cord-299038-e0nsol3y 64 12 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 64 13 ( ( -LRB- cord-299038-e0nsol3y 64 14 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 64 15 , , , cord-299038-e0nsol3y 64 16 CD169 CD169 NNP cord-299038-e0nsol3y 64 17 ) ) -RRB- cord-299038-e0nsol3y 64 18 plays play VBZ cord-299038-e0nsol3y 64 19 a a DT cord-299038-e0nsol3y 64 20 crucial crucial JJ cord-299038-e0nsol3y 64 21 role role NN cord-299038-e0nsol3y 64 22 in in IN cord-299038-e0nsol3y 64 23 limiting limit VBG cord-299038-e0nsol3y 64 24 bacterial bacterial JJ cord-299038-e0nsol3y 64 25 dissemination dissemination NN cord-299038-e0nsol3y 64 26 . . . cord-299038-e0nsol3y 65 1 This this DT cord-299038-e0nsol3y 65 2 receptor receptor NN cord-299038-e0nsol3y 65 3 , , , cord-299038-e0nsol3y 65 4 uniquely uniquely RB cord-299038-e0nsol3y 65 5 expressed express VBN cord-299038-e0nsol3y 65 6 in in IN cord-299038-e0nsol3y 65 7 the the DT cord-299038-e0nsol3y 65 8 marginal marginal NNP cord-299038-e0nsol3y 65 9 metallophilic metallophilic NNP cord-299038-e0nsol3y 65 10 and and CC cord-299038-e0nsol3y 65 11 subcapsular subcapsular NNP cord-299038-e0nsol3y 65 12 sinus sinus NNP cord-299038-e0nsol3y 65 13 macrophages macrophage NNS cord-299038-e0nsol3y 65 14 , , , cord-299038-e0nsol3y 65 15 recognizing recognize VBG cord-299038-e0nsol3y 65 16 the the DT cord-299038-e0nsol3y 65 17 same same JJ cord-299038-e0nsol3y 65 18 key key JJ cord-299038-e0nsol3y 65 19 Sia Sia NNP cord-299038-e0nsol3y 65 20 epitope epitope NN cord-299038-e0nsol3y 65 21 on on IN cord-299038-e0nsol3y 65 22 the the DT cord-299038-e0nsol3y 65 23 GBS GBS NNP cord-299038-e0nsol3y 65 24 surface surface NN cord-299038-e0nsol3y 65 25 , , , cord-299038-e0nsol3y 65 26 however however RB cord-299038-e0nsol3y 65 27 lacks lack VBZ cord-299038-e0nsol3y 65 28 an an DT cord-299038-e0nsol3y 65 29 intracellular intracellular JJ cord-299038-e0nsol3y 65 30 ITM ITM NNP cord-299038-e0nsol3y 65 31 motif motif NN cord-299038-e0nsol3y 65 32 ( ( -LRB- cord-299038-e0nsol3y 65 33 Crocker Crocker NNP cord-299038-e0nsol3y 65 34 and and CC cord-299038-e0nsol3y 65 35 Gordon Gordon NNP cord-299038-e0nsol3y 65 36 1989 1989 CD cord-299038-e0nsol3y 65 37 ; ; : cord-299038-e0nsol3y 65 38 Crocker Crocker NNP cord-299038-e0nsol3y 65 39 et et NNP cord-299038-e0nsol3y 65 40 al al NNP cord-299038-e0nsol3y 65 41 . . . cord-299038-e0nsol3y 65 42 1994 1994 CD cord-299038-e0nsol3y 65 43 ) ) -RRB- cord-299038-e0nsol3y 65 44 . . . cord-299038-e0nsol3y 66 1 Siglec-1 Siglec-1 NNS cord-299038-e0nsol3y 66 2 binding bind VBG cord-299038-e0nsol3y 66 3 to to IN cord-299038-e0nsol3y 66 4 GBS GBS NNP cord-299038-e0nsol3y 67 1 CPS CPS NNP cord-299038-e0nsol3y 67 2 Sia Sia NNP cord-299038-e0nsol3y 67 3 promoted promote VBD cord-299038-e0nsol3y 67 4 phagocytic phagocytic JJ cord-299038-e0nsol3y 67 5 and and CC cord-299038-e0nsol3y 67 6 bactericidal bactericidal JJ cord-299038-e0nsol3y 67 7 activity activity NN cord-299038-e0nsol3y 67 8 of of IN cord-299038-e0nsol3y 67 9 macrophages macrophage NNS cord-299038-e0nsol3y 67 10 in in IN cord-299038-e0nsol3y 67 11 vitro vitro FW cord-299038-e0nsol3y 67 12 and and CC cord-299038-e0nsol3y 67 13 restricts restrict VBZ cord-299038-e0nsol3y 67 14 GBS GBS NNP cord-299038-e0nsol3y 67 15 dissemination dissemination NN cord-299038-e0nsol3y 67 16 in in IN cord-299038-e0nsol3y 67 17 vivo vivo NN cord-299038-e0nsol3y 68 1 ( ( -LRB- cord-299038-e0nsol3y 68 2 Chang Chang NNP cord-299038-e0nsol3y 68 3 et et NNP cord-299038-e0nsol3y 68 4 al al NNP cord-299038-e0nsol3y 68 5 . . NNP cord-299038-e0nsol3y 68 6 2014b 2014b CD cord-299038-e0nsol3y 68 7 ) ) -RRB- cord-299038-e0nsol3y 68 8 . . . cord-299038-e0nsol3y 69 1 Loss loss NN cord-299038-e0nsol3y 69 2 of of IN cord-299038-e0nsol3y 69 3 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 69 4 expression expression NN cord-299038-e0nsol3y 69 5 not not RB cord-299038-e0nsol3y 69 6 only only RB cord-299038-e0nsol3y 69 7 affected affect VBD cord-299038-e0nsol3y 69 8 the the DT cord-299038-e0nsol3y 69 9 macrophage macrophage NN cord-299038-e0nsol3y 69 10 sampling sampling NN cord-299038-e0nsol3y 69 11 and and CC cord-299038-e0nsol3y 69 12 trapping trap VBG cord-299038-e0nsol3y 69 13 capabilities capability NNS cord-299038-e0nsol3y 69 14 but but CC cord-299038-e0nsol3y 69 15 also also RB cord-299038-e0nsol3y 69 16 the the DT cord-299038-e0nsol3y 69 17 production production NN cord-299038-e0nsol3y 69 18 of of IN cord-299038-e0nsol3y 69 19 anti anti JJ cord-299038-e0nsol3y 69 20 - - JJ cord-299038-e0nsol3y 69 21 GBS GBS NNP cord-299038-e0nsol3y 69 22 antibodies antibody NNS cord-299038-e0nsol3y 69 23 , , , cord-299038-e0nsol3y 69 24 suggesting suggest VBG cord-299038-e0nsol3y 69 25 a a DT cord-299038-e0nsol3y 69 26 key key JJ cord-299038-e0nsol3y 69 27 role role NN cord-299038-e0nsol3y 69 28 in in IN cord-299038-e0nsol3y 69 29 optimization optimization NN cord-299038-e0nsol3y 69 30 of of IN cord-299038-e0nsol3y 69 31 antigen antigen NN cord-299038-e0nsol3y 69 32 presentation presentation NN cord-299038-e0nsol3y 69 33 and and CC cord-299038-e0nsol3y 69 34 subsequent subsequent JJ cord-299038-e0nsol3y 69 35 adaptive adaptive JJ cord-299038-e0nsol3y 69 36 immune immune JJ cord-299038-e0nsol3y 69 37 response response NN cord-299038-e0nsol3y 69 38 against against IN cord-299038-e0nsol3y 69 39 sialylated sialylated JJ cord-299038-e0nsol3y 69 40 pathogens pathogen NNS cord-299038-e0nsol3y 69 41 ( ( -LRB- cord-299038-e0nsol3y 69 42 Chang Chang NNP cord-299038-e0nsol3y 69 43 et et NNP cord-299038-e0nsol3y 69 44 al al NNP cord-299038-e0nsol3y 69 45 . . NNP cord-299038-e0nsol3y 69 46 2014b 2014b CD cord-299038-e0nsol3y 69 47 ) ) -RRB- cord-299038-e0nsol3y 69 48 . . . cord-299038-e0nsol3y 70 1 Another another DT cord-299038-e0nsol3y 70 2 evolutionary evolutionary JJ cord-299038-e0nsol3y 70 3 adaption adaption NN cord-299038-e0nsol3y 70 4 of of IN cord-299038-e0nsol3y 70 5 the the DT cord-299038-e0nsol3y 70 6 host host NN cord-299038-e0nsol3y 70 7 to to TO cord-299038-e0nsol3y 70 8 defeat defeat VB cord-299038-e0nsol3y 70 9 pathogen pathogen NN cord-299038-e0nsol3y 70 10 Siglec Siglec NNP cord-299038-e0nsol3y 70 11 hijacking hijacking NN cord-299038-e0nsol3y 70 12 is be VBZ cord-299038-e0nsol3y 70 13 the the DT cord-299038-e0nsol3y 70 14 emergence emergence NN cord-299038-e0nsol3y 70 15 of of IN cord-299038-e0nsol3y 70 16 activating activate VBG cord-299038-e0nsol3y 70 17 Siglecs Siglecs NNP cord-299038-e0nsol3y 70 18 with with IN cord-299038-e0nsol3y 70 19 the the DT cord-299038-e0nsol3y 70 20 potential potential NN cord-299038-e0nsol3y 70 21 to to TO cord-299038-e0nsol3y 70 22 counteract counteract VB cord-299038-e0nsol3y 70 23 inhibitory inhibitory JJ cord-299038-e0nsol3y 70 24 Siglec Siglec NNP cord-299038-e0nsol3y 70 25 - - HYPH cord-299038-e0nsol3y 70 26 mediated mediate VBN cord-299038-e0nsol3y 70 27 immune immune JJ cord-299038-e0nsol3y 70 28 suppression suppression NN cord-299038-e0nsol3y 70 29 . . . cord-299038-e0nsol3y 71 1 In in IN cord-299038-e0nsol3y 71 2 2006 2006 CD cord-299038-e0nsol3y 71 3 , , , cord-299038-e0nsol3y 71 4 Angata Angata NNP cord-299038-e0nsol3y 71 5 et et NNP cord-299038-e0nsol3y 71 6 al al NNP cord-299038-e0nsol3y 71 7 . . NNP cord-299038-e0nsol3y 71 8 discovered discover VBD cord-299038-e0nsol3y 71 9 Siglec-14 Siglec-14 NNP cord-299038-e0nsol3y 71 10 , , , cord-299038-e0nsol3y 71 11 which which WDT cord-299038-e0nsol3y 71 12 possesses possess VBZ cord-299038-e0nsol3y 71 13 nearly nearly RB cord-299038-e0nsol3y 71 14 identical identical JJ cord-299038-e0nsol3y 71 15 Siabinding Siabinding NNP cord-299038-e0nsol3y 71 16 domain domain NN cord-299038-e0nsol3y 71 17 as as IN cord-299038-e0nsol3y 71 18 inhibitory inhibitory JJ cord-299038-e0nsol3y 71 19 Siglec-5 Siglec-5 NNPS cord-299038-e0nsol3y 71 20 through through IN cord-299038-e0nsol3y 71 21 gene gene NN cord-299038-e0nsol3y 71 22 conversion conversion NN cord-299038-e0nsol3y 71 23 , , , cord-299038-e0nsol3y 71 24 but but CC cord-299038-e0nsol3y 71 25 is be VBZ cord-299038-e0nsol3y 71 26 coupled couple VBN cord-299038-e0nsol3y 71 27 with with IN cord-299038-e0nsol3y 71 28 DAP12 DAP12 NNP cord-299038-e0nsol3y 71 29 , , , cord-299038-e0nsol3y 71 30 an an DT cord-299038-e0nsol3y 71 31 ITAM ITAM NNP cord-299038-e0nsol3y 71 32 motif motif NN cord-299038-e0nsol3y 71 33 bearing bear VBG cord-299038-e0nsol3y 71 34 adaptor adaptor NN cord-299038-e0nsol3y 71 35 ( ( -LRB- cord-299038-e0nsol3y 71 36 Angata Angata NNP cord-299038-e0nsol3y 71 37 et et NNP cord-299038-e0nsol3y 71 38 al al NNP cord-299038-e0nsol3y 71 39 . . . cord-299038-e0nsol3y 71 40 2006 2006 CD cord-299038-e0nsol3y 71 41 ) ) -RRB- cord-299038-e0nsol3y 71 42 . . . cord-299038-e0nsol3y 72 1 Thus thus RB cord-299038-e0nsol3y 72 2 Siglec-5 Siglec-5 NNP cord-299038-e0nsol3y 72 3 and and CC cord-299038-e0nsol3y 72 4 -14 -14 NNP cord-299038-e0nsol3y 72 5 represent represent VBP cord-299038-e0nsol3y 72 6 paired pair VBN cord-299038-e0nsol3y 72 7 receptors receptor NNS cord-299038-e0nsol3y 72 8 with with IN cord-299038-e0nsol3y 72 9 opposite opposite JJ cord-299038-e0nsol3y 72 10 signaling signal VBG cord-299038-e0nsol3y 72 11 effects effect NNS cord-299038-e0nsol3y 72 12 . . . cord-299038-e0nsol3y 73 1 For for IN cord-299038-e0nsol3y 73 2 example example NN cord-299038-e0nsol3y 73 3 , , , cord-299038-e0nsol3y 73 4 on on IN cord-299038-e0nsol3y 73 5 neutrophils neutrophil NNS cord-299038-e0nsol3y 73 6 and and CC cord-299038-e0nsol3y 73 7 amniotic amniotic NN cord-299038-e0nsol3y 73 8 epithelium epithelium NN cord-299038-e0nsol3y 73 9 , , , cord-299038-e0nsol3y 73 10 β β NN cord-299038-e0nsol3y 73 11 protein protein NN cord-299038-e0nsol3y 73 12 - - HYPH cord-299038-e0nsol3y 73 13 expressing express VBG cord-299038-e0nsol3y 73 14 GBS GBS NNP cord-299038-e0nsol3y 73 15 can can MD cord-299038-e0nsol3y 73 16 bind bind VB cord-299038-e0nsol3y 73 17 to to IN cord-299038-e0nsol3y 73 18 Siglec-5 Siglec-5 NNP cord-299038-e0nsol3y 74 1 and and CC cord-299038-e0nsol3y 74 2 Siglec-14 Siglec-14 NNP cord-299038-e0nsol3y 74 3 , , , cord-299038-e0nsol3y 74 4 with with IN cord-299038-e0nsol3y 74 5 the the DT cord-299038-e0nsol3y 74 6 latter latter JJ cord-299038-e0nsol3y 74 7 engagement engagement NN cord-299038-e0nsol3y 74 8 stimulating stimulate VBG cord-299038-e0nsol3y 74 9 p38 p38 CD cord-299038-e0nsol3y 74 10 MAP MAP NNP cord-299038-e0nsol3y 74 11 kinase kinase NN cord-299038-e0nsol3y 74 12 and and CC cord-299038-e0nsol3y 74 13 AKT AKT NNP cord-299038-e0nsol3y 74 14 signaling signal VBG cord-299038-e0nsol3y 74 15 to to TO cord-299038-e0nsol3y 74 16 promote promote VB cord-299038-e0nsol3y 74 17 more more RBR cord-299038-e0nsol3y 74 18 efficient efficient JJ cord-299038-e0nsol3y 74 19 bacterial bacterial JJ cord-299038-e0nsol3y 74 20 clearance clearance NN cord-299038-e0nsol3y 74 21 . . . cord-299038-e0nsol3y 75 1 Notably notably RB cord-299038-e0nsol3y 75 2 , , , cord-299038-e0nsol3y 75 3 a a DT cord-299038-e0nsol3y 75 4 SIGLEC14-null siglec14-null NN cord-299038-e0nsol3y 75 5 polymorphism polymorphism NN cord-299038-e0nsol3y 75 6 is be VBZ cord-299038-e0nsol3y 75 7 present present JJ cord-299038-e0nsol3y 75 8 in in IN cord-299038-e0nsol3y 75 9 some some DT cord-299038-e0nsol3y 75 10 humans human NNS cord-299038-e0nsol3y 75 11 , , , cord-299038-e0nsol3y 75 12 caused cause VBN cord-299038-e0nsol3y 75 13 by by IN cord-299038-e0nsol3y 75 14 fusion fusion NN cord-299038-e0nsol3y 75 15 between between IN cord-299038-e0nsol3y 75 16 SIGLEC14 siglec14 NN cord-299038-e0nsol3y 75 17 and and CC cord-299038-e0nsol3y 75 18 SIGLEC5 siglec5 JJ cord-299038-e0nsol3y 75 19 genes gene NNS cord-299038-e0nsol3y 75 20 , , , cord-299038-e0nsol3y 75 21 resulting result VBG cord-299038-e0nsol3y 75 22 in in IN cord-299038-e0nsol3y 75 23 functional functional JJ cord-299038-e0nsol3y 75 24 deletion deletion NN cord-299038-e0nsol3y 75 25 of of IN cord-299038-e0nsol3y 75 26 Siglec-14 siglec-14 JJ cord-299038-e0nsol3y 75 27 expression expression NN cord-299038-e0nsol3y 75 28 ( ( -LRB- cord-299038-e0nsol3y 75 29 Yamanaka Yamanaka NNP cord-299038-e0nsol3y 75 30 et et FW cord-299038-e0nsol3y 75 31 al al NNP cord-299038-e0nsol3y 75 32 . . NNP cord-299038-e0nsol3y 75 33 2009 2009 CD cord-299038-e0nsol3y 75 34 ) ) -RRB- cord-299038-e0nsol3y 75 35 . . . cord-299038-e0nsol3y 76 1 A a DT cord-299038-e0nsol3y 76 2 genetic genetic JJ cord-299038-e0nsol3y 76 3 survey survey NN cord-299038-e0nsol3y 76 4 of of IN cord-299038-e0nsol3y 76 5 the the DT cord-299038-e0nsol3y 76 6 SIGLEC14-null siglec14-null NN cord-299038-e0nsol3y 76 7 polymorphism polymorphism NN cord-299038-e0nsol3y 76 8 and and CC cord-299038-e0nsol3y 76 9 GBS GBS NNP cord-299038-e0nsol3y 76 10 colonization colonization NN cord-299038-e0nsol3y 76 11 and and CC cord-299038-e0nsol3y 76 12 premature premature JJ cord-299038-e0nsol3y 76 13 delivery delivery NN cord-299038-e0nsol3y 76 14 found find VBD cord-299038-e0nsol3y 76 15 that that IN cord-299038-e0nsol3y 76 16 SIGLEC14-null siglec14-null NN cord-299038-e0nsol3y 76 17 allele allele NN cord-299038-e0nsol3y 76 18 is be VBZ cord-299038-e0nsol3y 76 19 associated associate VBN cord-299038-e0nsol3y 76 20 with with IN cord-299038-e0nsol3y 76 21 higher high JJR cord-299038-e0nsol3y 76 22 GBS GBS NNP cord-299038-e0nsol3y 76 23 colonization colonization NN cord-299038-e0nsol3y 76 24 in in IN cord-299038-e0nsol3y 76 25 mothers mother NNS cord-299038-e0nsol3y 76 26 and and CC cord-299038-e0nsol3y 76 27 more more RBR cord-299038-e0nsol3y 76 28 frequent frequent JJ cord-299038-e0nsol3y 76 29 premature premature JJ cord-299038-e0nsol3y 76 30 birth birth NN cord-299038-e0nsol3y 76 31 of of IN cord-299038-e0nsol3y 76 32 infants infant NNS cord-299038-e0nsol3y 76 33 from from IN cord-299038-e0nsol3y 76 34 GBS GBS NNP cord-299038-e0nsol3y 76 35 - - HYPH cord-299038-e0nsol3y 76 36 positive positive JJ cord-299038-e0nsol3y 76 37 pregnancies pregnancy NNS cord-299038-e0nsol3y 77 1 ( ( -LRB- cord-299038-e0nsol3y 77 2 Ali Ali NNP cord-299038-e0nsol3y 77 3 et et NNP cord-299038-e0nsol3y 77 4 al al NNP cord-299038-e0nsol3y 77 5 . . NNP cord-299038-e0nsol3y 77 6 2014 2014 CD cord-299038-e0nsol3y 77 7 ) ) -RRB- cord-299038-e0nsol3y 77 8 . . . cord-299038-e0nsol3y 78 1 In in IN cord-299038-e0nsol3y 78 2 addition addition NN cord-299038-e0nsol3y 78 3 to to IN cord-299038-e0nsol3y 78 4 GBS GBS NNP cord-299038-e0nsol3y 78 5 , , , cord-299038-e0nsol3y 78 6 the the DT cord-299038-e0nsol3y 78 7 pathogens pathogen NNS cord-299038-e0nsol3y 78 8 Escherichia Escherichia NNP cord-299038-e0nsol3y 78 9 coli coli VBZ cord-299038-e0nsol3y 78 10 K1 K1 NNP cord-299038-e0nsol3y 78 11 and and CC cord-299038-e0nsol3y 78 12 Neisseria Neisseria NNP cord-299038-e0nsol3y 78 13 meningitidis meningitidis NN cord-299038-e0nsol3y 78 14 serotype serotype NN cord-299038-e0nsol3y 78 15 B b NN cord-299038-e0nsol3y 78 16 , , , cord-299038-e0nsol3y 78 17 important important JJ cord-299038-e0nsol3y 78 18 agents agent NNS cord-299038-e0nsol3y 78 19 of of IN cord-299038-e0nsol3y 78 20 bacterial bacterial JJ cord-299038-e0nsol3y 78 21 meningitis meningitis NN cord-299038-e0nsol3y 78 22 in in IN cord-299038-e0nsol3y 78 23 infants infant NNS cord-299038-e0nsol3y 78 24 and and CC cord-299038-e0nsol3y 78 25 children child NNS cord-299038-e0nsol3y 78 26 , , , cord-299038-e0nsol3y 78 27 possess possess VBP cord-299038-e0nsol3y 78 28 sialylated sialylate VBN cord-299038-e0nsol3y 78 29 capsules capsule NNS cord-299038-e0nsol3y 78 30 . . . cord-299038-e0nsol3y 79 1 The the DT cord-299038-e0nsol3y 79 2 CPS cp NNS cord-299038-e0nsol3y 79 3 produced produce VBN cord-299038-e0nsol3y 79 4 by by IN cord-299038-e0nsol3y 79 5 these these DT cord-299038-e0nsol3y 79 6 two two CD cord-299038-e0nsol3y 79 7 bacteria bacteria NNS cord-299038-e0nsol3y 79 8 resembles resemble VBZ cord-299038-e0nsol3y 79 9 the the DT cord-299038-e0nsol3y 79 10 same same JJ cord-299038-e0nsol3y 79 11 poly poly NN cord-299038-e0nsol3y 79 12 - - HYPH cord-299038-e0nsol3y 79 13 α2,8-Sia α2,8-sia XX cord-299038-e0nsol3y 79 14 ( ( -LRB- cord-299038-e0nsol3y 79 15 PSA PSA NNP cord-299038-e0nsol3y 79 16 ) ) -RRB- cord-299038-e0nsol3y 79 17 structure structure NN cord-299038-e0nsol3y 79 18 abundantly abundantly RB cord-299038-e0nsol3y 79 19 expressed express VBD cord-299038-e0nsol3y 79 20 on on IN cord-299038-e0nsol3y 79 21 neurons neuron NNS cord-299038-e0nsol3y 79 22 and and CC cord-299038-e0nsol3y 79 23 the the DT cord-299038-e0nsol3y 79 24 glia glia NN cord-299038-e0nsol3y 79 25 cells cell NNS cord-299038-e0nsol3y 79 26 of of IN cord-299038-e0nsol3y 79 27 the the DT cord-299038-e0nsol3y 79 28 developing develop VBG cord-299038-e0nsol3y 79 29 central central JJ cord-299038-e0nsol3y 79 30 nervous nervous JJ cord-299038-e0nsol3y 79 31 systems system NNS cord-299038-e0nsol3y 79 32 ( ( -LRB- cord-299038-e0nsol3y 79 33 CNS CNS NNP cord-299038-e0nsol3y 79 34 ) ) -RRB- cord-299038-e0nsol3y 79 35 is be VBZ cord-299038-e0nsol3y 79 36 critical critical JJ cord-299038-e0nsol3y 79 37 for for IN cord-299038-e0nsol3y 79 38 neuron neuron NN cord-299038-e0nsol3y 79 39 development development NN cord-299038-e0nsol3y 79 40 and and CC cord-299038-e0nsol3y 79 41 function function NN cord-299038-e0nsol3y 79 42 ( ( -LRB- cord-299038-e0nsol3y 79 43 Finne Finne NNP cord-299038-e0nsol3y 79 44 1982 1982 CD cord-299038-e0nsol3y 79 45 ; ; : cord-299038-e0nsol3y 79 46 Devi Devi NNP cord-299038-e0nsol3y 79 47 et et FW cord-299038-e0nsol3y 79 48 al al NNP cord-299038-e0nsol3y 79 49 . . . cord-299038-e0nsol3y 80 1 1991 1991 CD cord-299038-e0nsol3y 80 2 ; ; : cord-299038-e0nsol3y 80 3 Rutishauser Rutishauser NNP cord-299038-e0nsol3y 80 4 2008 2008 CD cord-299038-e0nsol3y 80 5 ) ) -RRB- cord-299038-e0nsol3y 80 6 . . . cord-299038-e0nsol3y 81 1 The the DT cord-299038-e0nsol3y 81 2 human human JJ cord-299038-e0nsol3y 81 3 - - HYPH cord-299038-e0nsol3y 81 4 specific specific JJ cord-299038-e0nsol3y 81 5 Siglec-11 Siglec-11 NNS cord-299038-e0nsol3y 81 6 shows show VBZ cord-299038-e0nsol3y 81 7 a a DT cord-299038-e0nsol3y 81 8 unique unique JJ cord-299038-e0nsol3y 81 9 expression expression NN cord-299038-e0nsol3y 81 10 pattern pattern NN cord-299038-e0nsol3y 81 11 in in IN cord-299038-e0nsol3y 81 12 human human JJ cord-299038-e0nsol3y 81 13 microglia microglia NNS cord-299038-e0nsol3y 81 14 and and CC cord-299038-e0nsol3y 81 15 selective selective JJ cord-299038-e0nsol3y 81 16 binding bind VBG cord-299038-e0nsol3y 81 17 preference preference NN cord-299038-e0nsol3y 81 18 to to IN cord-299038-e0nsol3y 81 19 α2,8-linked α2,8-linked UH cord-299038-e0nsol3y 81 20 Sias Sias NNP cord-299038-e0nsol3y 81 21 ( ( -LRB- cord-299038-e0nsol3y 81 22 Angata Angata NNP cord-299038-e0nsol3y 81 23 et et NNP cord-299038-e0nsol3y 81 24 al al NNP cord-299038-e0nsol3y 81 25 . . . cord-299038-e0nsol3y 81 26 2002 2002 CD cord-299038-e0nsol3y 81 27 ; ; : cord-299038-e0nsol3y 82 1 Hayakawa Hayakawa NNP cord-299038-e0nsol3y 82 2 et et NNP cord-299038-e0nsol3y 82 3 al al NNP cord-299038-e0nsol3y 82 4 . . NNP cord-299038-e0nsol3y 82 5 2005 2005 CD cord-299038-e0nsol3y 82 6 ) ) -RRB- cord-299038-e0nsol3y 82 7 . . . cord-299038-e0nsol3y 83 1 Engagement engagement NN cord-299038-e0nsol3y 83 2 of of IN cord-299038-e0nsol3y 83 3 Siglec-11 Siglec-11 NNS cord-299038-e0nsol3y 83 4 by by IN cord-299038-e0nsol3y 83 5 endogenous endogenous JJ cord-299038-e0nsol3y 83 6 host host NN cord-299038-e0nsol3y 84 1 PSA PSA NNP cord-299038-e0nsol3y 84 2 exerts exert VBZ cord-299038-e0nsol3y 84 3 protective protective JJ cord-299038-e0nsol3y 84 4 effects effect NNS cord-299038-e0nsol3y 84 5 against against IN cord-299038-e0nsol3y 84 6 inflammation inflammation NN cord-299038-e0nsol3y 84 7 - - HYPH cord-299038-e0nsol3y 84 8 mediated mediate VBN cord-299038-e0nsol3y 84 9 neurotoxicity neurotoxicity NN cord-299038-e0nsol3y 84 10 ( ( -LRB- cord-299038-e0nsol3y 84 11 Wang Wang NNP cord-299038-e0nsol3y 84 12 and and CC cord-299038-e0nsol3y 84 13 Neumann Neumann NNP cord-299038-e0nsol3y 84 14 2010 2010 CD cord-299038-e0nsol3y 84 15 ) ) -RRB- cord-299038-e0nsol3y 84 16 . . . cord-299038-e0nsol3y 85 1 The the DT cord-299038-e0nsol3y 85 2 mimicry mimicry NN cord-299038-e0nsol3y 85 3 of of IN cord-299038-e0nsol3y 85 4 mammalian mammalian JJ cord-299038-e0nsol3y 85 5 PSA PSA NNP cord-299038-e0nsol3y 85 6 by by IN cord-299038-e0nsol3y 85 7 E. E. NNP cord-299038-e0nsol3y 85 8 coli coli VBZ cord-299038-e0nsol3y 85 9 K1 K1 NNP cord-299038-e0nsol3y 85 10 and and CC cord-299038-e0nsol3y 85 11 N. N. NNP cord-299038-e0nsol3y 85 12 meningitidis meningitidis NNP cord-299038-e0nsol3y 85 13 type type NN cord-299038-e0nsol3y 85 14 B B NNP cord-299038-e0nsol3y 85 15 CPS CPS NNP cord-299038-e0nsol3y 85 16 may may MD cord-299038-e0nsol3y 85 17 , , , cord-299038-e0nsol3y 85 18 therefore therefore RB cord-299038-e0nsol3y 85 19 , , , cord-299038-e0nsol3y 85 20 target target VB cord-299038-e0nsol3y 85 21 Siglec-11 siglec-11 JJ cord-299038-e0nsol3y 85 22 expression expression NN cord-299038-e0nsol3y 85 23 on on IN cord-299038-e0nsol3y 85 24 microglia microglia NNS cord-299038-e0nsol3y 85 25 to to TO cord-299038-e0nsol3y 85 26 blunt blunt VB cord-299038-e0nsol3y 85 27 immune immune JJ cord-299038-e0nsol3y 85 28 responsiveness responsiveness NN cord-299038-e0nsol3y 85 29 and and CC cord-299038-e0nsol3y 85 30 facilitate facilitate VB cord-299038-e0nsol3y 85 31 neuroinvasion neuroinvasion NN cord-299038-e0nsol3y 85 32 , , , cord-299038-e0nsol3y 85 33 consistent consistent JJ cord-299038-e0nsol3y 85 34 with with IN cord-299038-e0nsol3y 85 35 the the DT cord-299038-e0nsol3y 85 36 high high JJ cord-299038-e0nsol3y 85 37 rates rate NNS cord-299038-e0nsol3y 85 38 of of IN cord-299038-e0nsol3y 85 39 mortality mortality NN cord-299038-e0nsol3y 85 40 and and CC cord-299038-e0nsol3y 85 41 serious serious JJ cord-299038-e0nsol3y 85 42 neurological neurological JJ cord-299038-e0nsol3y 85 43 sequelae sequela NNS cord-299038-e0nsol3y 85 44 seen see VBN cord-299038-e0nsol3y 85 45 with with IN cord-299038-e0nsol3y 85 46 these these DT cord-299038-e0nsol3y 85 47 pathogens pathogen NNS cord-299038-e0nsol3y 85 48 ( ( -LRB- cord-299038-e0nsol3y 85 49 Robbins Robbins NNP cord-299038-e0nsol3y 85 50 et et NNP cord-299038-e0nsol3y 85 51 al al NNP cord-299038-e0nsol3y 85 52 . . . cord-299038-e0nsol3y 85 53 1974 1974 CD cord-299038-e0nsol3y 85 54 ; ; : cord-299038-e0nsol3y 85 55 Kaper Kaper NNP cord-299038-e0nsol3y 85 56 et et NNP cord-299038-e0nsol3y 85 57 al al NNP cord-299038-e0nsol3y 85 58 . . . cord-299038-e0nsol3y 85 59 2004 2004 CD cord-299038-e0nsol3y 85 60 ) ) -RRB- cord-299038-e0nsol3y 85 61 . . . cord-299038-e0nsol3y 86 1 Interestingly interestingly RB cord-299038-e0nsol3y 86 2 , , , cord-299038-e0nsol3y 86 3 the the DT cord-299038-e0nsol3y 86 4 activating activate VBG cord-299038-e0nsol3y 86 5 Siglec-16 siglec-16 NN cord-299038-e0nsol3y 86 6 , , , cord-299038-e0nsol3y 86 7 which which WDT cord-299038-e0nsol3y 86 8 shares share VBZ cord-299038-e0nsol3y 86 9 over over IN cord-299038-e0nsol3y 86 10 99 99 CD cord-299038-e0nsol3y 86 11 % % NN cord-299038-e0nsol3y 86 12 of of IN cord-299038-e0nsol3y 86 13 sequence sequence NN cord-299038-e0nsol3y 86 14 identity identity NN cord-299038-e0nsol3y 86 15 to to IN cord-299038-e0nsol3y 86 16 the the DT cord-299038-e0nsol3y 86 17 first first JJ cord-299038-e0nsol3y 86 18 two two CD cord-299038-e0nsol3y 86 19 Ig ig JJ cord-299038-e0nsol3y 86 20 - - HYPH cord-299038-e0nsol3y 86 21 like like JJ cord-299038-e0nsol3y 86 22 domain domain NN cord-299038-e0nsol3y 86 23 of of IN cord-299038-e0nsol3y 86 24 Siglec-11 Siglec-11 NNS cord-299038-e0nsol3y 86 25 but but CC cord-299038-e0nsol3y 86 26 is be VBZ cord-299038-e0nsol3y 86 27 coupled couple VBN cord-299038-e0nsol3y 86 28 with with IN cord-299038-e0nsol3y 86 29 ITAMcontaining ITAMcontaining NNP cord-299038-e0nsol3y 86 30 DAP12 DAP12 NNP cord-299038-e0nsol3y 86 31 , , , cord-299038-e0nsol3y 86 32 was be VBD cord-299038-e0nsol3y 86 33 later later RB cord-299038-e0nsol3y 86 34 discovered discover VBN cord-299038-e0nsol3y 86 35 to to TO cord-299038-e0nsol3y 86 36 be be VB cord-299038-e0nsol3y 86 37 a a DT cord-299038-e0nsol3y 86 38 paired paired JJ cord-299038-e0nsol3y 86 39 receptor receptor NN cord-299038-e0nsol3y 86 40 of of IN cord-299038-e0nsol3y 86 41 Siglec-11 Siglec-11 NNS cord-299038-e0nsol3y 86 42 allowing allow VBG cord-299038-e0nsol3y 86 43 fine fine RB cord-299038-e0nsol3y 86 44 - - HYPH cord-299038-e0nsol3y 86 45 tuning tuning NN cord-299038-e0nsol3y 86 46 of of IN cord-299038-e0nsol3y 86 47 immune immune JJ cord-299038-e0nsol3y 86 48 responses response NNS cord-299038-e0nsol3y 86 49 ( ( -LRB- cord-299038-e0nsol3y 86 50 Cao Cao NNP cord-299038-e0nsol3y 86 51 et et NNP cord-299038-e0nsol3y 86 52 al al NNP cord-299038-e0nsol3y 86 53 . . NNP cord-299038-e0nsol3y 86 54 2008 2008 CD cord-299038-e0nsol3y 86 55 ) ) -RRB- cord-299038-e0nsol3y 86 56 . . . cord-299038-e0nsol3y 87 1 Pathogenic pathogenic JJ cord-299038-e0nsol3y 87 2 E. E. NNP cord-299038-e0nsol3y 87 3 coli coli VBZ cord-299038-e0nsol3y 87 4 K1 K1 NNP cord-299038-e0nsol3y 87 5 engages engage VBZ cord-299038-e0nsol3y 87 6 inhibitory inhibitory JJ cord-299038-e0nsol3y 87 7 Siglec-11 Siglec-11 NNS cord-299038-e0nsol3y 87 8 through through IN cord-299038-e0nsol3y 87 9 their -PRON- PRP$ cord-299038-e0nsol3y 87 10 PSA PSA NNP cord-299038-e0nsol3y 87 11 capsule capsule NN cord-299038-e0nsol3y 87 12 to to TO cord-299038-e0nsol3y 87 13 inhibit inhibit VB cord-299038-e0nsol3y 87 14 macrophage macrophage NN cord-299038-e0nsol3y 87 15 anti anti JJ cord-299038-e0nsol3y 87 16 - - JJ cord-299038-e0nsol3y 87 17 bacterial bacterial JJ cord-299038-e0nsol3y 87 18 functions function NNS cord-299038-e0nsol3y 87 19 . . . cord-299038-e0nsol3y 88 1 In in IN cord-299038-e0nsol3y 88 2 contrast contrast NN cord-299038-e0nsol3y 88 3 , , , cord-299038-e0nsol3y 88 4 activating activate VBG cord-299038-e0nsol3y 88 5 Siglec-16 siglec-16 NN cord-299038-e0nsol3y 88 6 expressing express VBG cord-299038-e0nsol3y 88 7 macrophages macrophage NNS cord-299038-e0nsol3y 88 8 recognizes recognize VBZ cord-299038-e0nsol3y 88 9 the the DT cord-299038-e0nsol3y 88 10 same same JJ cord-299038-e0nsol3y 88 11 epitope epitope NN cord-299038-e0nsol3y 88 12 to to TO cord-299038-e0nsol3y 88 13 promote promote VB cord-299038-e0nsol3y 88 14 elimination elimination NN cord-299038-e0nsol3y 88 15 of of IN cord-299038-e0nsol3y 88 16 pathogen pathogen NN cord-299038-e0nsol3y 88 17 ( ( -LRB- cord-299038-e0nsol3y 88 18 Schwarz Schwarz NNP cord-299038-e0nsol3y 88 19 et et NNP cord-299038-e0nsol3y 88 20 al al NNP cord-299038-e0nsol3y 88 21 . . . cord-299038-e0nsol3y 88 22 2017 2017 CD cord-299038-e0nsol3y 88 23 ) ) -RRB- cord-299038-e0nsol3y 88 24 . . . cord-299038-e0nsol3y 89 1 In in IN cord-299038-e0nsol3y 89 2 sum sum NN cord-299038-e0nsol3y 89 3 , , , cord-299038-e0nsol3y 89 4 macrophage macrophage NN cord-299038-e0nsol3y 89 5 engagement engagement NN cord-299038-e0nsol3y 89 6 of of IN cord-299038-e0nsol3y 89 7 GBS GBS NNP cord-299038-e0nsol3y 89 8 β β NNP cord-299038-e0nsol3y 89 9 protein protein NN cord-299038-e0nsol3y 89 10 or or CC cord-299038-e0nsol3y 89 11 E. E. NNP cord-299038-e0nsol3y 89 12 coli coli VBZ cord-299038-e0nsol3y 89 13 K1 K1 NNP cord-299038-e0nsol3y 89 14 PSA PSA NNP cord-299038-e0nsol3y 89 15 capsule capsule NN cord-299038-e0nsol3y 89 16 illustrates illustrate VBZ cord-299038-e0nsol3y 89 17 an an DT cord-299038-e0nsol3y 89 18 evolutionary evolutionary JJ cord-299038-e0nsol3y 89 19 dynamic dynamic NN cord-299038-e0nsol3y 89 20 in in IN cord-299038-e0nsol3y 89 21 which which WDT cord-299038-e0nsol3y 89 22 the the DT cord-299038-e0nsol3y 89 23 activating activate VBG cord-299038-e0nsol3y 89 24 member member NN cord-299038-e0nsol3y 89 25 of of IN cord-299038-e0nsol3y 89 26 the the DT cord-299038-e0nsol3y 89 27 Siglec Siglec NNP cord-299038-e0nsol3y 89 28 receptor receptor NN cord-299038-e0nsol3y 89 29 pair pair NN cord-299038-e0nsol3y 89 30 may may MD cord-299038-e0nsol3y 89 31 override override VB cord-299038-e0nsol3y 89 32 the the DT cord-299038-e0nsol3y 89 33 immune immune JJ cord-299038-e0nsol3y 89 34 suppressive suppressive JJ cord-299038-e0nsol3y 89 35 responses response NNS cord-299038-e0nsol3y 89 36 generated generate VBN cord-299038-e0nsol3y 89 37 by by IN cord-299038-e0nsol3y 89 38 pathogen pathogen NN cord-299038-e0nsol3y 89 39 mimicry mimicry NN cord-299038-e0nsol3y 89 40 of of IN cord-299038-e0nsol3y 89 41 the the DT cord-299038-e0nsol3y 89 42 inhibitory inhibitory JJ cord-299038-e0nsol3y 89 43 Siglec Siglec NNP cord-299038-e0nsol3y 89 44 member member NN cord-299038-e0nsol3y 89 45 . . . cord-299038-e0nsol3y 90 1 In in IN cord-299038-e0nsol3y 90 2 addition addition NN cord-299038-e0nsol3y 90 3 to to IN cord-299038-e0nsol3y 90 4 the the DT cord-299038-e0nsol3y 90 5 CPS cp NNS cord-299038-e0nsol3y 90 6 , , , cord-299038-e0nsol3y 90 7 sialylation sialylation NN cord-299038-e0nsol3y 90 8 of of IN cord-299038-e0nsol3y 90 9 LPS LPS NNP cord-299038-e0nsol3y 90 10 and and CC cord-299038-e0nsol3y 90 11 LOS LOS NNP cord-299038-e0nsol3y 90 12 is be VBZ cord-299038-e0nsol3y 90 13 also also RB cord-299038-e0nsol3y 90 14 a a DT cord-299038-e0nsol3y 90 15 prominent prominent JJ cord-299038-e0nsol3y 90 16 binding binding NN cord-299038-e0nsol3y 90 17 target target NN cord-299038-e0nsol3y 90 18 of of IN cord-299038-e0nsol3y 90 19 Siglecs Siglecs NNP cord-299038-e0nsol3y 90 20 . . . cord-299038-e0nsol3y 91 1 For for IN cord-299038-e0nsol3y 91 2 example example NN cord-299038-e0nsol3y 91 3 , , , cord-299038-e0nsol3y 91 4 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 91 5 and and CC cord-299038-e0nsol3y 91 6 Siglec-5 Siglec-5 NNPS cord-299038-e0nsol3y 91 7 bind bind VB cord-299038-e0nsol3y 91 8 to to IN cord-299038-e0nsol3y 91 9 the the DT cord-299038-e0nsol3y 91 10 sialylated sialylated JJ cord-299038-e0nsol3y 91 11 LPS LPS NNP cord-299038-e0nsol3y 91 12 of of IN cord-299038-e0nsol3y 91 13 N. N. NNP cord-299038-e0nsol3y 91 14 meningitidis meningitidis NNP cord-299038-e0nsol3y 91 15 , , , cord-299038-e0nsol3y 91 16 and and CC cord-299038-e0nsol3y 91 17 cells cell NNS cord-299038-e0nsol3y 91 18 expressing express VBG cord-299038-e0nsol3y 91 19 either either CC cord-299038-e0nsol3y 91 20 Siglec Siglec NNP cord-299038-e0nsol3y 91 21 internalized internalize VBD cord-299038-e0nsol3y 91 22 meningococci meningococci NNS cord-299038-e0nsol3y 91 23 in in IN cord-299038-e0nsol3y 91 24 a a DT cord-299038-e0nsol3y 91 25 Siglec Siglec NNP cord-299038-e0nsol3y 91 26 - - HYPH cord-299038-e0nsol3y 91 27 and and CC cord-299038-e0nsol3y 91 28 Sia Sia NNP cord-299038-e0nsol3y 91 29 - - HYPH cord-299038-e0nsol3y 91 30 dependent dependent JJ cord-299038-e0nsol3y 91 31 manner manner NN cord-299038-e0nsol3y 91 32 ( ( -LRB- cord-299038-e0nsol3y 91 33 Jones Jones NNP cord-299038-e0nsol3y 91 34 et et NNP cord-299038-e0nsol3y 91 35 al al NNP cord-299038-e0nsol3y 91 36 . . NNP cord-299038-e0nsol3y 91 37 2003 2003 CD cord-299038-e0nsol3y 91 38 ) ) -RRB- cord-299038-e0nsol3y 91 39 . . . cord-299038-e0nsol3y 92 1 Strains strain NNS cord-299038-e0nsol3y 92 2 of of IN cord-299038-e0nsol3y 92 3 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 92 4 jejuni jejuni NNP cord-299038-e0nsol3y 92 5 express express VBP cord-299038-e0nsol3y 92 6 various various JJ cord-299038-e0nsol3y 92 7 monosialylated monosialylate VBN cord-299038-e0nsol3y 92 8 and and CC cord-299038-e0nsol3y 92 9 disialylated disialylate VBD cord-299038-e0nsol3y 92 10 LOS LOS NNP cord-299038-e0nsol3y 92 11 with with IN cord-299038-e0nsol3y 92 12 α2,3or α2,3or XX cord-299038-e0nsol3y 93 1 α2,3/2,8linked α2,3/2,8linked NNP cord-299038-e0nsol3y 93 2 Sia Sia NNP cord-299038-e0nsol3y 93 3 residues residue NNS cord-299038-e0nsol3y 93 4 , , , cord-299038-e0nsol3y 93 5 respectively respectively RB cord-299038-e0nsol3y 93 6 , , , cord-299038-e0nsol3y 93 7 which which WDT cord-299038-e0nsol3y 93 8 perfectly perfectly RB cord-299038-e0nsol3y 93 9 mimic mimic VBP cord-299038-e0nsol3y 93 10 host host NN cord-299038-e0nsol3y 93 11 neural neural JJ cord-299038-e0nsol3y 93 12 gangliosides ganglioside NNS cord-299038-e0nsol3y 93 13 GM1 GM1 NNP cord-299038-e0nsol3y 93 14 , , , cord-299038-e0nsol3y 93 15 GD1a GD1a NNP cord-299038-e0nsol3y 93 16 , , , cord-299038-e0nsol3y 93 17 GD3 GD3 NNP cord-299038-e0nsol3y 93 18 , , , cord-299038-e0nsol3y 93 19 or or CC cord-299038-e0nsol3y 93 20 GT1a GT1a NNP cord-299038-e0nsol3y 93 21 . . . cord-299038-e0nsol3y 94 1 Colonization colonization NN cord-299038-e0nsol3y 94 2 with with IN cord-299038-e0nsol3y 94 3 C. C. NNP cord-299038-e0nsol3y 94 4 jejuni jejuni NNP cord-299038-e0nsol3y 94 5 strains strain NNS cord-299038-e0nsol3y 94 6 possessing possess VBG cord-299038-e0nsol3y 94 7 sialylated sialylate VBN cord-299038-e0nsol3y 94 8 LOS LOS NNP cord-299038-e0nsol3y 94 9 is be VBZ cord-299038-e0nsol3y 94 10 epidemiologically epidemiologically RB cord-299038-e0nsol3y 94 11 associated associate VBN cord-299038-e0nsol3y 94 12 with with IN cord-299038-e0nsol3y 94 13 higher high JJR cord-299038-e0nsol3y 94 14 risk risk NN cord-299038-e0nsol3y 94 15 of of IN cord-299038-e0nsol3y 94 16 developing develop VBG cord-299038-e0nsol3y 94 17 a a DT cord-299038-e0nsol3y 94 18 postinfectious postinfectious JJ cord-299038-e0nsol3y 94 19 autoimmune autoimmune JJ cord-299038-e0nsol3y 94 20 neuropathy neuropathy NN cord-299038-e0nsol3y 94 21 termed term VBD cord-299038-e0nsol3y 94 22 Guillain Guillain NNP cord-299038-e0nsol3y 94 23 - - HYPH cord-299038-e0nsol3y 94 24 Barré Barré NNP cord-299038-e0nsol3y 94 25 syndrome syndrome NN cord-299038-e0nsol3y 94 26 ( ( -LRB- cord-299038-e0nsol3y 94 27 Jacobs Jacobs NNP cord-299038-e0nsol3y 94 28 et et NNP cord-299038-e0nsol3y 94 29 al al NNP cord-299038-e0nsol3y 94 30 . . . cord-299038-e0nsol3y 94 31 1996 1996 CD cord-299038-e0nsol3y 94 32 ; ; . cord-299038-e0nsol3y 95 1 Willison Willison NNP cord-299038-e0nsol3y 95 2 et et NNP cord-299038-e0nsol3y 95 3 al al NNP cord-299038-e0nsol3y 95 4 . . . cord-299038-e0nsol3y 95 5 2016 2016 CD cord-299038-e0nsol3y 95 6 ; ; : cord-299038-e0nsol3y 95 7 Willison Willison NNP cord-299038-e0nsol3y 95 8 and and CC cord-299038-e0nsol3y 95 9 Yuki Yuki NNP cord-299038-e0nsol3y 95 10 2002 2002 CD cord-299038-e0nsol3y 95 11 ) ) -RRB- cord-299038-e0nsol3y 95 12 . . . cord-299038-e0nsol3y 96 1 Several several JJ cord-299038-e0nsol3y 96 2 human human NN cord-299038-e0nsol3y 96 3 Siglecs Siglecs NNP cord-299038-e0nsol3y 96 4 recognize recognize VBP cord-299038-e0nsol3y 96 5 these these DT cord-299038-e0nsol3y 96 6 particular particular JJ cord-299038-e0nsol3y 96 7 sialylated sialylate VBN cord-299038-e0nsol3y 96 8 LOS LOS NNP cord-299038-e0nsol3y 96 9 structures structure NNS cord-299038-e0nsol3y 96 10 , , , cord-299038-e0nsol3y 96 11 although although IN cord-299038-e0nsol3y 96 12 the the DT cord-299038-e0nsol3y 96 13 functional functional JJ cord-299038-e0nsol3y 96 14 consequences consequence NNS cord-299038-e0nsol3y 96 15 of of IN cord-299038-e0nsol3y 96 16 this this DT cord-299038-e0nsol3y 96 17 interaction interaction NN cord-299038-e0nsol3y 96 18 require require VBP cord-299038-e0nsol3y 96 19 further further JJ cord-299038-e0nsol3y 96 20 investigation investigation NN cord-299038-e0nsol3y 96 21 . . . cord-299038-e0nsol3y 97 1 Siglec-7 Siglec-7 NNP cord-299038-e0nsol3y 97 2 , , , cord-299038-e0nsol3y 97 3 which which WDT cord-299038-e0nsol3y 97 4 is be VBZ cord-299038-e0nsol3y 97 5 expressed express VBN cord-299038-e0nsol3y 97 6 on on IN cord-299038-e0nsol3y 97 7 natural natural JJ cord-299038-e0nsol3y 97 8 killer killer NN cord-299038-e0nsol3y 97 9 ( ( -LRB- cord-299038-e0nsol3y 97 10 NK NK NNP cord-299038-e0nsol3y 97 11 ) ) -RRB- cord-299038-e0nsol3y 97 12 cells cell NNS cord-299038-e0nsol3y 97 13 , , , cord-299038-e0nsol3y 97 14 monocytes monocyte NNS cord-299038-e0nsol3y 97 15 , , , cord-299038-e0nsol3y 97 16 and and CC cord-299038-e0nsol3y 97 17 dendritic dendritic JJ cord-299038-e0nsol3y 97 18 cells cell NNS cord-299038-e0nsol3y 97 19 ( ( -LRB- cord-299038-e0nsol3y 97 20 DCs DCs NNP cord-299038-e0nsol3y 97 21 ) ) -RRB- cord-299038-e0nsol3y 97 22 , , , cord-299038-e0nsol3y 97 23 can can MD cord-299038-e0nsol3y 97 24 mediate mediate VB cord-299038-e0nsol3y 97 25 specific specific JJ cord-299038-e0nsol3y 97 26 Sia sia JJ cord-299038-e0nsol3y 97 27 - - HYPH cord-299038-e0nsol3y 97 28 dependent dependent JJ cord-299038-e0nsol3y 97 29 interaction interaction NN cord-299038-e0nsol3y 97 30 with with IN cord-299038-e0nsol3y 97 31 C. C. NNP cord-299038-e0nsol3y 97 32 jejuni jejuni NNP cord-299038-e0nsol3y 97 33 LOS LOS NNP cord-299038-e0nsol3y 98 1 ( ( -LRB- cord-299038-e0nsol3y 98 2 Avril Avril NNP cord-299038-e0nsol3y 98 3 et et NNP cord-299038-e0nsol3y 98 4 al al NNP cord-299038-e0nsol3y 98 5 . . . cord-299038-e0nsol3y 98 6 2006 2006 CD cord-299038-e0nsol3y 98 7 ) ) -RRB- cord-299038-e0nsol3y 98 8 . . . cord-299038-e0nsol3y 99 1 C. C. NNP cord-299038-e0nsol3y 99 2 jejuni jejuni NNP cord-299038-e0nsol3y 99 3 strains strain NNS cord-299038-e0nsol3y 99 4 recognized recognize VBN cord-299038-e0nsol3y 99 5 by by IN cord-299038-e0nsol3y 99 6 Siglec-7 Siglec-7 NNP cord-299038-e0nsol3y 99 7 express express JJ cord-299038-e0nsol3y 99 8 terminal terminal JJ cord-299038-e0nsol3y 99 9 disialylated disialylated JJ cord-299038-e0nsol3y 99 10 residues residue NNS cord-299038-e0nsol3y 99 11 mimicking mimic VBG cord-299038-e0nsol3y 99 12 host host NN cord-299038-e0nsol3y 99 13 GQ1blike GQ1blike NNP cord-299038-e0nsol3y 99 14 epitopes epitope NNS cord-299038-e0nsol3y 99 15 , , , cord-299038-e0nsol3y 99 16 including include VBG cord-299038-e0nsol3y 99 17 GD1c GD1c NNP cord-299038-e0nsol3y 99 18 and and CC cord-299038-e0nsol3y 99 19 GD3 GD3 NNP cord-299038-e0nsol3y 99 20 . . . cord-299038-e0nsol3y 100 1 The the DT cord-299038-e0nsol3y 100 2 Siglec-7 Siglec-7 NNP cord-299038-e0nsol3y 100 3 binding binding NN cord-299038-e0nsol3y 100 4 signal signal NN cord-299038-e0nsol3y 100 5 of of IN cord-299038-e0nsol3y 100 6 C. C. NNP cord-299038-e0nsol3y 100 7 jejuni jejuni NNP cord-299038-e0nsol3y 100 8 correlates correlate VBZ cord-299038-e0nsol3y 100 9 with with IN cord-299038-e0nsol3y 100 10 its -PRON- PRP$ cord-299038-e0nsol3y 100 11 ability ability NN cord-299038-e0nsol3y 100 12 to to TO cord-299038-e0nsol3y 100 13 elicit elicit VB cord-299038-e0nsol3y 100 14 anti anti JJ cord-299038-e0nsol3y 100 15 - - JJ cord-299038-e0nsol3y 100 16 GQ1b GQ1b NNP cord-299038-e0nsol3y 100 17 antibodies antibody NNS cord-299038-e0nsol3y 100 18 , , , cord-299038-e0nsol3y 100 19 and and CC cord-299038-e0nsol3y 100 20 strains strain NNS cord-299038-e0nsol3y 100 21 recognized recognize VBN cord-299038-e0nsol3y 100 22 by by IN cord-299038-e0nsol3y 100 23 Siglec-7 Siglec-7 NNP cord-299038-e0nsol3y 100 24 were be VBD cord-299038-e0nsol3y 100 25 particularly particularly RB cord-299038-e0nsol3y 100 26 associated associate VBN cord-299038-e0nsol3y 100 27 with with IN cord-299038-e0nsol3y 100 28 oculomotor oculomotor NN cord-299038-e0nsol3y 100 29 weakness weakness NN cord-299038-e0nsol3y 100 30 in in IN cord-299038-e0nsol3y 100 31 Guillain Guillain NNP cord-299038-e0nsol3y 100 32 - - HYPH cord-299038-e0nsol3y 100 33 Barré Barré NNP cord-299038-e0nsol3y 100 34 syndrome syndrome NN cord-299038-e0nsol3y 100 35 and and CC cord-299038-e0nsol3y 100 36 its -PRON- PRP$ cord-299038-e0nsol3y 100 37 so so RB cord-299038-e0nsol3y 100 38 - - HYPH cord-299038-e0nsol3y 100 39 called call VBN cord-299038-e0nsol3y 100 40 Miller Miller NNP cord-299038-e0nsol3y 100 41 - - HYPH cord-299038-e0nsol3y 100 42 Fisher Fisher NNP cord-299038-e0nsol3y 100 43 variant variant NN cord-299038-e0nsol3y 100 44 ( ( -LRB- cord-299038-e0nsol3y 100 45 Heikema Heikema NNP cord-299038-e0nsol3y 100 46 et et NNP cord-299038-e0nsol3y 100 47 al al NNP cord-299038-e0nsol3y 100 48 . . NNP cord-299038-e0nsol3y 100 49 2013 2013 CD cord-299038-e0nsol3y 100 50 ) ) -RRB- cord-299038-e0nsol3y 100 51 . . . cord-299038-e0nsol3y 101 1 On on IN cord-299038-e0nsol3y 101 2 the the DT cord-299038-e0nsol3y 101 3 other other JJ cord-299038-e0nsol3y 101 4 hand hand NN cord-299038-e0nsol3y 101 5 , , , cord-299038-e0nsol3y 101 6 C. C. NNP cord-299038-e0nsol3y 101 7 jejuni jejuni NNP cord-299038-e0nsol3y 101 8 with with IN cord-299038-e0nsol3y 101 9 α2,3-linked α2,3-linked XX cord-299038-e0nsol3y 101 10 Sia Sia NNP cord-299038-e0nsol3y 101 11 on on IN cord-299038-e0nsol3y 101 12 the the DT cord-299038-e0nsol3y 101 13 LOS LOS NNP cord-299038-e0nsol3y 101 14 chain chain NN cord-299038-e0nsol3y 101 15 showed show VBD cord-299038-e0nsol3y 101 16 strong strong JJ cord-299038-e0nsol3y 101 17 interaction interaction NN cord-299038-e0nsol3y 101 18 with with IN cord-299038-e0nsol3y 101 19 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 101 20 , , , cord-299038-e0nsol3y 101 21 which which WDT cord-299038-e0nsol3y 101 22 facilitated facilitate VBD cord-299038-e0nsol3y 101 23 bacterial bacterial JJ cord-299038-e0nsol3y 101 24 uptake uptake NN cord-299038-e0nsol3y 101 25 and and CC cord-299038-e0nsol3y 101 26 induce induce VB cord-299038-e0nsol3y 101 27 higher high JJR cord-299038-e0nsol3y 101 28 macrophage macrophage NN cord-299038-e0nsol3y 101 29 production production NN cord-299038-e0nsol3y 101 30 of of IN cord-299038-e0nsol3y 101 31 the the DT cord-299038-e0nsol3y 101 32 pro pro JJ cord-299038-e0nsol3y 101 33 - - JJ cord-299038-e0nsol3y 101 34 inflammatory inflammatory JJ cord-299038-e0nsol3y 101 35 cytokine cytokine NN cord-299038-e0nsol3y 101 36 IL-6 IL-6 NNP cord-299038-e0nsol3y 101 37 ( ( -LRB- cord-299038-e0nsol3y 101 38 Heikema Heikema NNP cord-299038-e0nsol3y 101 39 et et NNP cord-299038-e0nsol3y 101 40 al al NNP cord-299038-e0nsol3y 101 41 . . NNP cord-299038-e0nsol3y 101 42 2013 2013 CD cord-299038-e0nsol3y 101 43 ) ) -RRB- cord-299038-e0nsol3y 101 44 . . . cord-299038-e0nsol3y 102 1 A a DT cord-299038-e0nsol3y 102 2 key key JJ cord-299038-e0nsol3y 102 3 role role NN cord-299038-e0nsol3y 102 4 of of IN cord-299038-e0nsol3y 102 5 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 102 6 in in IN cord-299038-e0nsol3y 102 7 recognition recognition NN cord-299038-e0nsol3y 102 8 of of IN cord-299038-e0nsol3y 102 9 sialylated sialylate VBN cord-299038-e0nsol3y 102 10 C. C. NNP cord-299038-e0nsol3y 102 11 jejuni jejuni NNP cord-299038-e0nsol3y 102 12 LOS LOS NNP cord-299038-e0nsol3y 102 13 was be VBD cord-299038-e0nsol3y 102 14 confirmed confirm VBN cord-299038-e0nsol3y 102 15 in in IN cord-299038-e0nsol3y 102 16 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 102 17 deficient deficient JJ cord-299038-e0nsol3y 102 18 animals animal NNS cord-299038-e0nsol3y 102 19 . . . cord-299038-e0nsol3y 103 1 Bone bone NN cord-299038-e0nsol3y 103 2 - - HYPH cord-299038-e0nsol3y 103 3 marrow marrow NN cord-299038-e0nsol3y 103 4 - - HYPH cord-299038-e0nsol3y 103 5 derived derive VBN cord-299038-e0nsol3y 103 6 macrophages macrophage NNS cord-299038-e0nsol3y 103 7 from from IN cord-299038-e0nsol3y 103 8 mice mouse NNS cord-299038-e0nsol3y 103 9 lacking lack VBG cord-299038-e0nsol3y 103 10 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 103 11 showed show VBD cord-299038-e0nsol3y 103 12 greatly greatly RB cord-299038-e0nsol3y 103 13 reduced reduce VBN cord-299038-e0nsol3y 103 14 phagocytosis phagocytosis NN cord-299038-e0nsol3y 103 15 of of IN cord-299038-e0nsol3y 103 16 sialylated sialylate VBN cord-299038-e0nsol3y 103 17 C. C. NNP cord-299038-e0nsol3y 103 18 jejuni jejuni NNP cord-299038-e0nsol3y 103 19 , , , cord-299038-e0nsol3y 103 20 coupled couple VBN cord-299038-e0nsol3y 103 21 with with IN cord-299038-e0nsol3y 103 22 reduced reduced JJ cord-299038-e0nsol3y 103 23 production production NN cord-299038-e0nsol3y 103 24 of of IN cord-299038-e0nsol3y 103 25 proinflammatory proinflammatory JJ cord-299038-e0nsol3y 103 26 cytokines cytokine NNS cord-299038-e0nsol3y 103 27 and and CC cord-299038-e0nsol3y 103 28 type type NN cord-299038-e0nsol3y 103 29 I -PRON- PRP cord-299038-e0nsol3y 104 1 interferon interferon NN cord-299038-e0nsol3y 104 2 responses response NNS cord-299038-e0nsol3y 104 3 ( ( -LRB- cord-299038-e0nsol3y 104 4 Klaas Klaas NNP cord-299038-e0nsol3y 104 5 and and CC cord-299038-e0nsol3y 104 6 Crocker Crocker NNP cord-299038-e0nsol3y 104 7 2012 2012 CD cord-299038-e0nsol3y 104 8 ) ) -RRB- cord-299038-e0nsol3y 104 9 . . . cord-299038-e0nsol3y 105 1 Sialylated Sialylated NNP cord-299038-e0nsol3y 105 2 LOS LOS NNP cord-299038-e0nsol3y 105 3 is be VBZ cord-299038-e0nsol3y 105 4 important important JJ cord-299038-e0nsol3y 105 5 in in IN cord-299038-e0nsol3y 105 6 DC DC NNP cord-299038-e0nsol3y 105 7 and and CC cord-299038-e0nsol3y 105 8 macrophage macrophage NN cord-299038-e0nsol3y 105 9 activation activation NN cord-299038-e0nsol3y 105 10 as as RB cord-299038-e0nsol3y 105 11 well well RB cord-299038-e0nsol3y 105 12 as as IN cord-299038-e0nsol3y 105 13 subsequent subsequent JJ cord-299038-e0nsol3y 105 14 T t NN cord-299038-e0nsol3y 105 15 cell cell NN cord-299038-e0nsol3y 105 16 polarization polarization NN cord-299038-e0nsol3y 105 17 and and CC cord-299038-e0nsol3y 105 18 B b NN cord-299038-e0nsol3y 105 19 cell cell NN cord-299038-e0nsol3y 105 20 activation activation NN cord-299038-e0nsol3y 105 21 . . . cord-299038-e0nsol3y 106 1 Removal removal NN cord-299038-e0nsol3y 106 2 of of IN cord-299038-e0nsol3y 106 3 Sia Sia NNP cord-299038-e0nsol3y 106 4 from from IN cord-299038-e0nsol3y 106 5 the the DT cord-299038-e0nsol3y 106 6 C. C. NNP cord-299038-e0nsol3y 106 7 jejuni jejuni NNP cord-299038-e0nsol3y 106 8 LOS LOS NNP cord-299038-e0nsol3y 106 9 causes cause VBZ cord-299038-e0nsol3y 106 10 reduced reduce VBN cord-299038-e0nsol3y 106 11 myeloid myeloid JJ cord-299038-e0nsol3y 106 12 cell cell NN cord-299038-e0nsol3y 106 13 activation activation NN cord-299038-e0nsol3y 106 14 and and CC cord-299038-e0nsol3y 106 15 subsequent subsequent JJ cord-299038-e0nsol3y 106 16 B b NN cord-299038-e0nsol3y 106 17 cell cell NN cord-299038-e0nsol3y 106 18 responses response NNS cord-299038-e0nsol3y 106 19 ( ( -LRB- cord-299038-e0nsol3y 106 20 Kuijf Kuijf NNP cord-299038-e0nsol3y 106 21 et et NNP cord-299038-e0nsol3y 106 22 al al NNP cord-299038-e0nsol3y 106 23 . . NNP cord-299038-e0nsol3y 106 24 2010 2010 CD cord-299038-e0nsol3y 106 25 ; ; : cord-299038-e0nsol3y 106 26 Huizinga Huizinga NNP cord-299038-e0nsol3y 106 27 et et NNP cord-299038-e0nsol3y 106 28 al al NNP cord-299038-e0nsol3y 106 29 . . . cord-299038-e0nsol3y 107 1 2012 2012 CD cord-299038-e0nsol3y 108 1 Huizinga Huizinga NNP cord-299038-e0nsol3y 108 2 et et NNP cord-299038-e0nsol3y 108 3 al al NNP cord-299038-e0nsol3y 108 4 . . NNP cord-299038-e0nsol3y 108 5 , , , cord-299038-e0nsol3y 108 6 2013 2013 CD cord-299038-e0nsol3y 108 7 . . . cord-299038-e0nsol3y 109 1 Varied varied JJ cord-299038-e0nsol3y 109 2 sialylated sialylated JJ cord-299038-e0nsol3y 109 3 LOS LOS NNP cord-299038-e0nsol3y 109 4 structures structure NNS cord-299038-e0nsol3y 109 5 differentially differentially RB cord-299038-e0nsol3y 109 6 modulate modulate VBP cord-299038-e0nsol3y 109 7 DC DC NNP cord-299038-e0nsol3y 109 8 - - HYPH cord-299038-e0nsol3y 109 9 mediated mediate VBN cord-299038-e0nsol3y 109 10 T t NN cord-299038-e0nsol3y 109 11 cell cell NN cord-299038-e0nsol3y 109 12 polarization polarization NN cord-299038-e0nsol3y 109 13 in in IN cord-299038-e0nsol3y 109 14 a a DT cord-299038-e0nsol3y 109 15 Siglec Siglec NNP cord-299038-e0nsol3y 109 16 - - HYPH cord-299038-e0nsol3y 109 17 dependent dependent JJ cord-299038-e0nsol3y 109 18 manner manner NN cord-299038-e0nsol3y 109 19 , , . cord-299038-e0nsol3y 110 1 wherein wherein WRB cord-299038-e0nsol3y 110 2 the the DT cord-299038-e0nsol3y 110 3 GD1a GD1a NNP cord-299038-e0nsol3y 110 4 / / SYM cord-299038-e0nsol3y 110 5 GM1a GM1a NNP cord-299038-e0nsol3y 110 6 mimic mimic VBP cord-299038-e0nsol3y 110 7 induced induce VBN cord-299038-e0nsol3y 110 8 a a DT cord-299038-e0nsol3y 110 9 more more RBR cord-299038-e0nsol3y 110 10 pronounced pronounced JJ cord-299038-e0nsol3y 110 11 Th2 th2 CD cord-299038-e0nsol3y 110 12 skewing skewing NN cord-299038-e0nsol3y 110 13 , , , cord-299038-e0nsol3y 110 14 while while IN cord-299038-e0nsol3y 110 15 the the DT cord-299038-e0nsol3y 110 16 GD1c GD1c NNP cord-299038-e0nsol3y 110 17 mimic mimic VB cord-299038-e0nsol3y 110 18 preferentially preferentially RB cord-299038-e0nsol3y 110 19 stimulated stimulate VBD cord-299038-e0nsol3y 110 20 Th1 th1 NN cord-299038-e0nsol3y 110 21 responses response NNS cord-299038-e0nsol3y 110 22 ( ( -LRB- cord-299038-e0nsol3y 110 23 Bax Bax NNP cord-299038-e0nsol3y 110 24 et et NNP cord-299038-e0nsol3y 110 25 al al NNP cord-299038-e0nsol3y 110 26 . . NNP cord-299038-e0nsol3y 110 27 2011 2011 CD cord-299038-e0nsol3y 110 28 ) ) -RRB- cord-299038-e0nsol3y 110 29 . . . cord-299038-e0nsol3y 111 1 These these DT cord-299038-e0nsol3y 111 2 observations observation NNS cord-299038-e0nsol3y 111 3 suggest suggest VBP cord-299038-e0nsol3y 111 4 that that IN cord-299038-e0nsol3y 111 5 targeting target VBG cord-299038-e0nsol3y 111 6 distinct distinct JJ cord-299038-e0nsol3y 111 7 DC DC NNP cord-299038-e0nsol3y 111 8 - - HYPH cord-299038-e0nsol3y 111 9 expressed express VBN cord-299038-e0nsol3y 111 10 Siglecs Siglecs NNP cord-299038-e0nsol3y 111 11 may may MD cord-299038-e0nsol3y 111 12 represent represent VB cord-299038-e0nsol3y 111 13 a a DT cord-299038-e0nsol3y 111 14 potential potential JJ cord-299038-e0nsol3y 111 15 strategy strategy NN cord-299038-e0nsol3y 111 16 for for IN cord-299038-e0nsol3y 111 17 manipulating manipulate VBG cord-299038-e0nsol3y 111 18 Th Th NNP cord-299038-e0nsol3y 111 19 cell cell NN cord-299038-e0nsol3y 111 20 differentiation differentiation NN cord-299038-e0nsol3y 111 21 programs program NNS cord-299038-e0nsol3y 111 22 and and CC cord-299038-e0nsol3y 111 23 forestalling forestall VBG cord-299038-e0nsol3y 111 24 autoimmune autoimmune JJ cord-299038-e0nsol3y 111 25 disease disease NN cord-299038-e0nsol3y 111 26 post post NN cord-299038-e0nsol3y 111 27 C. C. NNP cord-299038-e0nsol3y 111 28 jejuni jejuni NNP cord-299038-e0nsol3y 111 29 infection infection NN cord-299038-e0nsol3y 111 30 . . . cord-299038-e0nsol3y 112 1 In in IN cord-299038-e0nsol3y 112 2 addition addition NN cord-299038-e0nsol3y 112 3 to to IN cord-299038-e0nsol3y 112 4 modulating modulate VBG cord-299038-e0nsol3y 112 5 host host NN cord-299038-e0nsol3y 112 6 DC DC NNP cord-299038-e0nsol3y 112 7 functions function NNS cord-299038-e0nsol3y 112 8 via via IN cord-299038-e0nsol3y 112 9 its -PRON- PRP$ cord-299038-e0nsol3y 112 10 sialylated sialylated JJ cord-299038-e0nsol3y 112 11 LOS LOS NNP cord-299038-e0nsol3y 112 12 , , , cord-299038-e0nsol3y 112 13 C. C. NNP cord-299038-e0nsol3y 112 14 jejuni jejuni NNP cord-299038-e0nsol3y 112 15 triggers trigger VBZ cord-299038-e0nsol3y 112 16 IL-10 IL-10 NNP cord-299038-e0nsol3y 112 17 production production NN cord-299038-e0nsol3y 112 18 of of IN cord-299038-e0nsol3y 112 19 DCs DCs NNP cord-299038-e0nsol3y 112 20 via via IN cord-299038-e0nsol3y 112 21 engaging engage VBG cord-299038-e0nsol3y 112 22 Siglec-10 Siglec-10 NNS cord-299038-e0nsol3y 112 23 through through IN cord-299038-e0nsol3y 112 24 the the DT cord-299038-e0nsol3y 112 25 pseudaminic pseudaminic JJ cord-299038-e0nsol3y 112 26 acid acid NN cord-299038-e0nsol3y 112 27 residues residue NNS cord-299038-e0nsol3y 112 28 on on IN cord-299038-e0nsol3y 112 29 its -PRON- PRP$ cord-299038-e0nsol3y 112 30 flagella flagellum NNS cord-299038-e0nsol3y 112 31 ( ( -LRB- cord-299038-e0nsol3y 112 32 Stephenson Stephenson NNP cord-299038-e0nsol3y 112 33 et et NNP cord-299038-e0nsol3y 112 34 al al NNP cord-299038-e0nsol3y 112 35 . . NNP cord-299038-e0nsol3y 112 36 2014 2014 CD cord-299038-e0nsol3y 112 37 ) ) -RRB- cord-299038-e0nsol3y 112 38 . . . cord-299038-e0nsol3y 113 1 These these DT cord-299038-e0nsol3y 113 2 abundant abundant JJ cord-299038-e0nsol3y 113 3 Sia Sia NNP cord-299038-e0nsol3y 113 4 and and CC cord-299038-e0nsol3y 113 5 Sia Sia NNP cord-299038-e0nsol3y 113 6 - - HYPH cord-299038-e0nsol3y 113 7 like like JJ cord-299038-e0nsol3y 113 8 C. C. NNP cord-299038-e0nsol3y 113 9 jejuni jejuni NNP cord-299038-e0nsol3y 113 10 surface surface NN cord-299038-e0nsol3y 113 11 structures structure NNS cord-299038-e0nsol3y 113 12 ( ( -LRB- cord-299038-e0nsol3y 113 13 e.g. e.g. IN cord-299038-e0nsol3y 113 14 pseudaminic pseudaminic JJ cord-299038-e0nsol3y 113 15 acid acid NN cord-299038-e0nsol3y 113 16 ) ) -RRB- cord-299038-e0nsol3y 113 17 help help VBP cord-299038-e0nsol3y 113 18 mediate mediate VB cord-299038-e0nsol3y 113 19 a a DT cord-299038-e0nsol3y 113 20 complicated complicated JJ cord-299038-e0nsol3y 113 21 interaction interaction NN cord-299038-e0nsol3y 113 22 with with IN cord-299038-e0nsol3y 113 23 host host NN cord-299038-e0nsol3y 113 24 immune immune JJ cord-299038-e0nsol3y 113 25 cells cell NNS cord-299038-e0nsol3y 113 26 that that WDT cord-299038-e0nsol3y 113 27 may may MD cord-299038-e0nsol3y 113 28 impact impact VB cord-299038-e0nsol3y 113 29 C. C. NNP cord-299038-e0nsol3y 113 30 jejuni jejuni NNP cord-299038-e0nsol3y 113 31 human human JJ cord-299038-e0nsol3y 113 32 disease disease NN cord-299038-e0nsol3y 113 33 associations association NNS cord-299038-e0nsol3y 113 34 , , , cord-299038-e0nsol3y 113 35 ranging range VBG cord-299038-e0nsol3y 113 36 from from IN cord-299038-e0nsol3y 113 37 autoimmune autoimmune JJ cord-299038-e0nsol3y 113 38 neuropathies neuropathy NNS cord-299038-e0nsol3y 113 39 to to IN cord-299038-e0nsol3y 113 40 asymptomatic asymptomatic JJ cord-299038-e0nsol3y 113 41 colonization colonization NN cord-299038-e0nsol3y 113 42 in in IN cord-299038-e0nsol3y 113 43 individuals individual NNS cord-299038-e0nsol3y 113 44 with with IN cord-299038-e0nsol3y 113 45 repeated repeat VBN cord-299038-e0nsol3y 113 46 exposure exposure NN cord-299038-e0nsol3y 113 47 to to IN cord-299038-e0nsol3y 113 48 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 113 49 spp spp NNS cord-299038-e0nsol3y 113 50 . . . cord-299038-e0nsol3y 114 1 In in IN cord-299038-e0nsol3y 114 2 addition addition NN cord-299038-e0nsol3y 114 3 to to IN cord-299038-e0nsol3y 114 4 the the DT cord-299038-e0nsol3y 114 5 well well RB cord-299038-e0nsol3y 114 6 - - HYPH cord-299038-e0nsol3y 114 7 studied study VBN cord-299038-e0nsol3y 114 8 microorganisms microorganism NNS cord-299038-e0nsol3y 114 9 mentioned mention VBN cord-299038-e0nsol3y 114 10 above above RB cord-299038-e0nsol3y 114 11 , , , cord-299038-e0nsol3y 114 12 a a DT cord-299038-e0nsol3y 114 13 growing grow VBG cord-299038-e0nsol3y 114 14 list list NN cord-299038-e0nsol3y 114 15 of of IN cord-299038-e0nsol3y 114 16 bacterial bacterial JJ cord-299038-e0nsol3y 114 17 species specie NNS cord-299038-e0nsol3y 114 18 have have VBP cord-299038-e0nsol3y 114 19 been be VBN cord-299038-e0nsol3y 114 20 discovered discover VBN cord-299038-e0nsol3y 114 21 to to TO cord-299038-e0nsol3y 114 22 display display VB cord-299038-e0nsol3y 114 23 sialoglycoconjugates sialoglycoconjugate NNS cord-299038-e0nsol3y 114 24 on on IN cord-299038-e0nsol3y 114 25 their -PRON- PRP$ cord-299038-e0nsol3y 114 26 surfaces surface NNS cord-299038-e0nsol3y 114 27 , , , cord-299038-e0nsol3y 114 28 such such JJ cord-299038-e0nsol3y 114 29 as as IN cord-299038-e0nsol3y 114 30 Pseudomonas Pseudomonas NNP cord-299038-e0nsol3y 114 31 aeruginosa aeruginosa NN cord-299038-e0nsol3y 114 32 ( ( -LRB- cord-299038-e0nsol3y 114 33 Khatua Khatua NNP cord-299038-e0nsol3y 114 34 et et NNP cord-299038-e0nsol3y 114 35 al al NNP cord-299038-e0nsol3y 114 36 . . . cord-299038-e0nsol3y 114 37 2010 2010 CD cord-299038-e0nsol3y 115 1 ( ( -LRB- cord-299038-e0nsol3y 115 2 Khatua Khatua NNP cord-299038-e0nsol3y 115 3 et et NNP cord-299038-e0nsol3y 115 4 al al NNP cord-299038-e0nsol3y 115 5 . . NNP cord-299038-e0nsol3y 115 6 , , , cord-299038-e0nsol3y 115 7 2012 2012 CD cord-299038-e0nsol3y 115 8 , , , cord-299038-e0nsol3y 115 9 Klebsiella Klebsiella NNP cord-299038-e0nsol3y 115 10 pneumoniae pneumoniae NN cord-299038-e0nsol3y 115 11 ( ( -LRB- cord-299038-e0nsol3y 115 12 Lee Lee NNP cord-299038-e0nsol3y 115 13 et et NNP cord-299038-e0nsol3y 115 14 al al NNP cord-299038-e0nsol3y 115 15 . . NNP cord-299038-e0nsol3y 115 16 2014 2014 CD cord-299038-e0nsol3y 115 17 ) ) -RRB- cord-299038-e0nsol3y 115 18 , , , cord-299038-e0nsol3y 115 19 and and CC cord-299038-e0nsol3y 115 20 nontypeable nontypeable JJ cord-299038-e0nsol3y 115 21 Haemophilus haemophilus JJ cord-299038-e0nsol3y 115 22 influenzae influenzae NN cord-299038-e0nsol3y 115 23 ( ( -LRB- cord-299038-e0nsol3y 115 24 NTHi NTHi NNS cord-299038-e0nsol3y 115 25 ) ) -RRB- cord-299038-e0nsol3y 116 1 ( ( -LRB- cord-299038-e0nsol3y 116 2 Kalograiaki Kalograiaki NNP cord-299038-e0nsol3y 116 3 et et NNP cord-299038-e0nsol3y 116 4 al al NNP cord-299038-e0nsol3y 116 5 . . . cord-299038-e0nsol3y 116 6 2016 2016 CD cord-299038-e0nsol3y 116 7 ) ) -RRB- cord-299038-e0nsol3y 116 8 . . . cord-299038-e0nsol3y 117 1 P. P. NNP cord-299038-e0nsol3y 117 2 aeruginosa aeruginosa NNP cord-299038-e0nsol3y 117 3 recruits recruit NNS cord-299038-e0nsol3y 117 4 host host VBP cord-299038-e0nsol3y 117 5 sialoglycoproteins sialoglycoprotein NNS cord-299038-e0nsol3y 117 6 and and CC cord-299038-e0nsol3y 117 7 displays display VBZ cord-299038-e0nsol3y 117 8 them -PRON- PRP cord-299038-e0nsol3y 117 9 on on IN cord-299038-e0nsol3y 117 10 the the DT cord-299038-e0nsol3y 117 11 bacterial bacterial JJ cord-299038-e0nsol3y 117 12 surface surface NN cord-299038-e0nsol3y 117 13 , , , cord-299038-e0nsol3y 117 14 and and CC cord-299038-e0nsol3y 117 15 these these DT cord-299038-e0nsol3y 117 16 absorbed absorb VBN cord-299038-e0nsol3y 117 17 Sias Sias NNP cord-299038-e0nsol3y 117 18 can can MD cord-299038-e0nsol3y 117 19 enhance enhance VB cord-299038-e0nsol3y 117 20 bacterial bacterial JJ cord-299038-e0nsol3y 117 21 survival survival NN cord-299038-e0nsol3y 117 22 by by IN cord-299038-e0nsol3y 117 23 reducing reduce VBG cord-299038-e0nsol3y 117 24 complement complement JJ cord-299038-e0nsol3y 117 25 deposition deposition NN cord-299038-e0nsol3y 117 26 and and CC cord-299038-e0nsol3y 117 27 engaging engage VBG cord-299038-e0nsol3y 117 28 inhibitory inhibitory JJ cord-299038-e0nsol3y 117 29 Siglec-9 siglec-9 NN cord-299038-e0nsol3y 117 30 to to TO cord-299038-e0nsol3y 117 31 suppress suppress VB cord-299038-e0nsol3y 117 32 neutrophil neutrophil NN cord-299038-e0nsol3y 117 33 bactericidal bactericidal JJ cord-299038-e0nsol3y 117 34 machinery machinery NN cord-299038-e0nsol3y 117 35 ( ( -LRB- cord-299038-e0nsol3y 117 36 Khatua Khatua NNP cord-299038-e0nsol3y 117 37 et et NNP cord-299038-e0nsol3y 117 38 al al NNP cord-299038-e0nsol3y 117 39 . . . cord-299038-e0nsol3y 117 40 2010 2010 CD cord-299038-e0nsol3y 118 1 ( ( -LRB- cord-299038-e0nsol3y 118 2 Khatua Khatua NNP cord-299038-e0nsol3y 118 3 et et NNP cord-299038-e0nsol3y 118 4 al al NNP cord-299038-e0nsol3y 118 5 . . NNP cord-299038-e0nsol3y 118 6 , , , cord-299038-e0nsol3y 118 7 2012 2012 CD cord-299038-e0nsol3y 118 8 . . . cord-299038-e0nsol3y 119 1 K. K. NNP cord-299038-e0nsol3y 119 2 pneumoniae pneumoniae NNS cord-299038-e0nsol3y 119 3 exhibiting exhibit VBG cord-299038-e0nsol3y 119 4 a a DT cord-299038-e0nsol3y 119 5 hypermucoviscosity hypermucoviscosity NN cord-299038-e0nsol3y 119 6 phenotype phenotype NN cord-299038-e0nsol3y 119 7 possess possess VBP cord-299038-e0nsol3y 119 8 abundant abundant JJ cord-299038-e0nsol3y 119 9 Sia Sia NNP cord-299038-e0nsol3y 119 10 CPS CPS NNP cord-299038-e0nsol3y 119 11 ; ; : cord-299038-e0nsol3y 119 12 blocking block VBG cord-299038-e0nsol3y 119 13 of of IN cord-299038-e0nsol3y 119 14 the the DT cord-299038-e0nsol3y 119 15 pathogen pathogen NN cord-299038-e0nsol3y 119 16 's 's POS cord-299038-e0nsol3y 119 17 ability ability NN cord-299038-e0nsol3y 119 18 to to TO cord-299038-e0nsol3y 119 19 engage engage VB cord-299038-e0nsol3y 119 20 inhibitory inhibitory JJ cord-299038-e0nsol3y 119 21 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 119 22 enhances enhance VBZ cord-299038-e0nsol3y 119 23 neutrophil neutrophil NN cord-299038-e0nsol3y 119 24 bactericidal bactericidal JJ cord-299038-e0nsol3y 119 25 activity activity NN cord-299038-e0nsol3y 120 1 ( ( -LRB- cord-299038-e0nsol3y 120 2 Lee Lee NNP cord-299038-e0nsol3y 120 3 et et NNP cord-299038-e0nsol3y 120 4 al al NNP cord-299038-e0nsol3y 120 5 . . NNP cord-299038-e0nsol3y 120 6 2014 2014 CD cord-299038-e0nsol3y 120 7 ) ) -RRB- cord-299038-e0nsol3y 120 8 . . . cord-299038-e0nsol3y 121 1 NTHi NTHi NNP cord-299038-e0nsol3y 121 2 LOS LOS NNP cord-299038-e0nsol3y 121 3 also also RB cord-299038-e0nsol3y 121 4 contains contain VBZ cord-299038-e0nsol3y 121 5 a a DT cord-299038-e0nsol3y 121 6 terminal terminal JJ cord-299038-e0nsol3y 121 7 Sia Sia NNP cord-299038-e0nsol3y 121 8 residue residue NN cord-299038-e0nsol3y 121 9 that that WDT cord-299038-e0nsol3y 121 10 interacts interact VBZ cord-299038-e0nsol3y 121 11 with with IN cord-299038-e0nsol3y 121 12 Siglec-14 Siglec-14 NNP cord-299038-e0nsol3y 121 13 , , , cord-299038-e0nsol3y 121 14 which which WDT cord-299038-e0nsol3y 121 15 enhances enhance VBZ cord-299038-e0nsol3y 121 16 inflammatory inflammatory JJ cord-299038-e0nsol3y 121 17 cytokine cytokine NN cord-299038-e0nsol3y 121 18 production production NN cord-299038-e0nsol3y 121 19 in in IN cord-299038-e0nsol3y 121 20 Siglec-14-expressing siglec-14-expresse VBG cord-299038-e0nsol3y 121 21 macrophages macrophage NNS cord-299038-e0nsol3y 121 22 correlating correlate VBG cord-299038-e0nsol3y 121 23 to to IN cord-299038-e0nsol3y 121 24 COPD COPD NNP cord-299038-e0nsol3y 121 25 exacerbation exacerbation NN cord-299038-e0nsol3y 121 26 in in IN cord-299038-e0nsol3y 121 27 human human JJ cord-299038-e0nsol3y 121 28 patients patient NNS cord-299038-e0nsol3y 121 29 ( ( -LRB- cord-299038-e0nsol3y 121 30 Angata Angata NNP cord-299038-e0nsol3y 121 31 et et NNP cord-299038-e0nsol3y 121 32 al al NNP cord-299038-e0nsol3y 121 33 . . NNP cord-299038-e0nsol3y 121 34 2013 2013 CD cord-299038-e0nsol3y 121 35 ) ) -RRB- cord-299038-e0nsol3y 121 36 . . . cord-299038-e0nsol3y 122 1 All all PDT cord-299038-e0nsol3y 122 2 these these DT cord-299038-e0nsol3y 122 3 observations observation NNS cord-299038-e0nsol3y 122 4 suggest suggest VBP cord-299038-e0nsol3y 122 5 that that IN cord-299038-e0nsol3y 122 6 Sia Sia NNP cord-299038-e0nsol3y 122 7 molecular molecular JJ cord-299038-e0nsol3y 122 8 mimicry mimicry NN cord-299038-e0nsol3y 122 9 by by IN cord-299038-e0nsol3y 122 10 many many JJ cord-299038-e0nsol3y 122 11 medical medical JJ cord-299038-e0nsol3y 122 12 important important JJ cord-299038-e0nsol3y 122 13 bacteria bacteria NNS cord-299038-e0nsol3y 122 14 can can MD cord-299038-e0nsol3y 122 15 interplay interplay VB cord-299038-e0nsol3y 122 16 with with IN cord-299038-e0nsol3y 122 17 various various JJ cord-299038-e0nsol3y 122 18 Siglecs Siglecs NNP cord-299038-e0nsol3y 122 19 to to TO cord-299038-e0nsol3y 122 20 affect affect VB cord-299038-e0nsol3y 122 21 infectious infectious JJ cord-299038-e0nsol3y 122 22 risk risk NN cord-299038-e0nsol3y 122 23 and and CC cord-299038-e0nsol3y 122 24 clinical clinical JJ cord-299038-e0nsol3y 122 25 disease disease NN cord-299038-e0nsol3y 122 26 manifestations manifestation NNS cord-299038-e0nsol3y 122 27 . . . cord-299038-e0nsol3y 123 1 Glycosaminoglycans Glycosaminoglycans NNP cord-299038-e0nsol3y 123 2 ( ( -LRB- cord-299038-e0nsol3y 123 3 GAGs GAGs NNP cord-299038-e0nsol3y 123 4 ) ) -RRB- cord-299038-e0nsol3y 123 5 are be VBP cord-299038-e0nsol3y 123 6 another another DT cord-299038-e0nsol3y 123 7 family family NN cord-299038-e0nsol3y 123 8 of of IN cord-299038-e0nsol3y 123 9 complex complex JJ cord-299038-e0nsol3y 123 10 carbohydrates carbohydrate NNS cord-299038-e0nsol3y 123 11 ubiquitously ubiquitously RB cord-299038-e0nsol3y 123 12 present present JJ cord-299038-e0nsol3y 123 13 on on IN cord-299038-e0nsol3y 123 14 mammalian mammalian JJ cord-299038-e0nsol3y 123 15 host host NN cord-299038-e0nsol3y 123 16 cell cell NN cord-299038-e0nsol3y 123 17 surfaces surface NNS cord-299038-e0nsol3y 123 18 and and CC cord-299038-e0nsol3y 123 19 in in IN cord-299038-e0nsol3y 123 20 the the DT cord-299038-e0nsol3y 123 21 extracellular extracellular JJ cord-299038-e0nsol3y 123 22 matrix matrix NN cord-299038-e0nsol3y 123 23 , , , cord-299038-e0nsol3y 123 24 regulating regulate VBG cord-299038-e0nsol3y 123 25 a a DT cord-299038-e0nsol3y 123 26 wide wide JJ cord-299038-e0nsol3y 123 27 range range NN cord-299038-e0nsol3y 123 28 of of IN cord-299038-e0nsol3y 123 29 biological biological JJ cord-299038-e0nsol3y 123 30 functions function NNS cord-299038-e0nsol3y 123 31 from from IN cord-299038-e0nsol3y 123 32 cell cell NN cord-299038-e0nsol3y 123 33 adhesion adhesion NN cord-299038-e0nsol3y 123 34 and and CC cord-299038-e0nsol3y 123 35 cell cell NN cord-299038-e0nsol3y 123 36 migration migration NN cord-299038-e0nsol3y 123 37 to to IN cord-299038-e0nsol3y 123 38 tissue tissue NN cord-299038-e0nsol3y 123 39 repair repair NN cord-299038-e0nsol3y 123 40 and and CC cord-299038-e0nsol3y 123 41 immune immune JJ cord-299038-e0nsol3y 123 42 responses response NNS cord-299038-e0nsol3y 124 1 ( ( -LRB- cord-299038-e0nsol3y 124 2 Linhardt Linhardt NNP cord-299038-e0nsol3y 124 3 and and CC cord-299038-e0nsol3y 124 4 Toida Toida NNP cord-299038-e0nsol3y 124 5 2004 2004 CD cord-299038-e0nsol3y 124 6 ) ) -RRB- cord-299038-e0nsol3y 124 7 . . . cord-299038-e0nsol3y 125 1 In in IN cord-299038-e0nsol3y 125 2 another another DT cord-299038-e0nsol3y 125 3 instance instance NN cord-299038-e0nsol3y 125 4 of of IN cord-299038-e0nsol3y 125 5 molecular molecular JJ cord-299038-e0nsol3y 125 6 mimicry mimicry NN cord-299038-e0nsol3y 125 7 , , , cord-299038-e0nsol3y 125 8 GAG gag NN cord-299038-e0nsol3y 125 9 structures structure NNS cord-299038-e0nsol3y 125 10 have have VBP cord-299038-e0nsol3y 125 11 been be VBN cord-299038-e0nsol3y 125 12 discovered discover VBN cord-299038-e0nsol3y 125 13 in in IN cord-299038-e0nsol3y 125 14 several several JJ cord-299038-e0nsol3y 125 15 gram gram NN cord-299038-e0nsol3y 125 16 - - HYPH cord-299038-e0nsol3y 125 17 positive positive JJ cord-299038-e0nsol3y 125 18 and and CC cord-299038-e0nsol3y 125 19 gram gram JJ cord-299038-e0nsol3y 125 20 - - HYPH cord-299038-e0nsol3y 125 21 negative negative JJ cord-299038-e0nsol3y 125 22 bacterial bacterial JJ cord-299038-e0nsol3y 125 23 capsules capsule NNS cord-299038-e0nsol3y 125 24 ( ( -LRB- cord-299038-e0nsol3y 125 25 Wessels Wessels NNP cord-299038-e0nsol3y 125 26 et et NNP cord-299038-e0nsol3y 125 27 al al NNP cord-299038-e0nsol3y 125 28 . . . cord-299038-e0nsol3y 125 29 1994 1994 CD cord-299038-e0nsol3y 125 30 ; ; : cord-299038-e0nsol3y 125 31 Jann Jann NNP cord-299038-e0nsol3y 125 32 and and CC cord-299038-e0nsol3y 125 33 Jann Jann NNP cord-299038-e0nsol3y 125 34 1992 1992 CD cord-299038-e0nsol3y 125 35 ; ; : cord-299038-e0nsol3y 125 36 DeAngelis DeAngelis NNP cord-299038-e0nsol3y 125 37 2002 2002 CD cord-299038-e0nsol3y 125 38 ) ) -RRB- cord-299038-e0nsol3y 125 39 . . . cord-299038-e0nsol3y 126 1 The the DT cord-299038-e0nsol3y 126 2 GAG gag NN cord-299038-e0nsol3y 126 3 HA HA NNP cord-299038-e0nsol3y 126 4 is be VBZ cord-299038-e0nsol3y 126 5 structurally structurally RB cord-299038-e0nsol3y 126 6 identical identical JJ cord-299038-e0nsol3y 126 7 in in IN cord-299038-e0nsol3y 126 8 animals animal NNS cord-299038-e0nsol3y 126 9 and and CC cord-299038-e0nsol3y 126 10 in in IN cord-299038-e0nsol3y 126 11 the the DT cord-299038-e0nsol3y 126 12 capsule capsule NN cord-299038-e0nsol3y 126 13 of of IN cord-299038-e0nsol3y 126 14 group group NN cord-299038-e0nsol3y 126 15 A a DT cord-299038-e0nsol3y 126 16 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 126 17 ( ( -LRB- cord-299038-e0nsol3y 126 18 GAS gas NN cord-299038-e0nsol3y 126 19 ) ) -RRB- cord-299038-e0nsol3y 126 20 where where WRB cord-299038-e0nsol3y 126 21 it -PRON- PRP cord-299038-e0nsol3y 126 22 is be VBZ cord-299038-e0nsol3y 126 23 serving serve VBG cord-299038-e0nsol3y 126 24 as as IN cord-299038-e0nsol3y 126 25 a a DT cord-299038-e0nsol3y 126 26 molecular molecular JJ cord-299038-e0nsol3y 126 27 camouflage camouflage NN cord-299038-e0nsol3y 126 28 to to TO cord-299038-e0nsol3y 126 29 evade evade VB cord-299038-e0nsol3y 126 30 host host NN cord-299038-e0nsol3y 126 31 immune immune JJ cord-299038-e0nsol3y 126 32 responses response NNS cord-299038-e0nsol3y 126 33 ( ( -LRB- cord-299038-e0nsol3y 126 34 Wessels Wessels NNP cord-299038-e0nsol3y 126 35 et et NNP cord-299038-e0nsol3y 126 36 al al NNP cord-299038-e0nsol3y 126 37 . . . cord-299038-e0nsol3y 126 38 1994 1994 CD cord-299038-e0nsol3y 126 39 ; ; : cord-299038-e0nsol3y 126 40 Dale Dale NNP cord-299038-e0nsol3y 126 41 et et NNP cord-299038-e0nsol3y 126 42 al al NNP cord-299038-e0nsol3y 126 43 . . . cord-299038-e0nsol3y 126 44 1996 1996 CD cord-299038-e0nsol3y 126 45 ) ) -RRB- cord-299038-e0nsol3y 126 46 . . . cord-299038-e0nsol3y 127 1 Recently recently RB cord-299038-e0nsol3y 127 2 , , , cord-299038-e0nsol3y 127 3 GAS gas NN cord-299038-e0nsol3y 127 4 was be VBD cord-299038-e0nsol3y 127 5 shown show VBN cord-299038-e0nsol3y 127 6 to to TO cord-299038-e0nsol3y 127 7 use use VB cord-299038-e0nsol3y 127 8 its -PRON- PRP$ cord-299038-e0nsol3y 127 9 HA HA NNP cord-299038-e0nsol3y 127 10 capsule capsule NN cord-299038-e0nsol3y 127 11 to to TO cord-299038-e0nsol3y 127 12 target target VB cord-299038-e0nsol3y 127 13 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 127 14 on on IN cord-299038-e0nsol3y 127 15 neutrophils neutrophil NNS cord-299038-e0nsol3y 127 16 , , , cord-299038-e0nsol3y 127 17 thereby thereby RB cord-299038-e0nsol3y 127 18 blocking block VBG cord-299038-e0nsol3y 127 19 NET net JJ cord-299038-e0nsol3y 127 20 formation formation NN cord-299038-e0nsol3y 127 21 and and CC cord-299038-e0nsol3y 127 22 oxidative oxidative JJ cord-299038-e0nsol3y 127 23 burst burst NN cord-299038-e0nsol3y 127 24 to to TO cord-299038-e0nsol3y 127 25 inhibit inhibit VB cord-299038-e0nsol3y 127 26 bactericidal bactericidal JJ cord-299038-e0nsol3y 127 27 function function NN cord-299038-e0nsol3y 128 1 ( ( -LRB- cord-299038-e0nsol3y 128 2 Secundino Secundino NNP cord-299038-e0nsol3y 128 3 et et NNP cord-299038-e0nsol3y 128 4 al al NNP cord-299038-e0nsol3y 128 5 . . . cord-299038-e0nsol3y 128 6 2016 2016 CD cord-299038-e0nsol3y 128 7 ) ) -RRB- cord-299038-e0nsol3y 128 8 . . . cord-299038-e0nsol3y 129 1 It -PRON- PRP cord-299038-e0nsol3y 129 2 is be VBZ cord-299038-e0nsol3y 129 3 an an DT cord-299038-e0nsol3y 129 4 interesting interesting JJ cord-299038-e0nsol3y 129 5 example example NN cord-299038-e0nsol3y 129 6 of of IN cord-299038-e0nsol3y 129 7 convergent convergent JJ cord-299038-e0nsol3y 129 8 evolution evolution NN cord-299038-e0nsol3y 129 9 that that IN cord-299038-e0nsol3y 129 10 two two CD cord-299038-e0nsol3y 129 11 structurally structurally RB cord-299038-e0nsol3y 129 12 unrelated unrelated JJ cord-299038-e0nsol3y 129 13 carbohydrates carbohydrate NNS cord-299038-e0nsol3y 129 14 , , , cord-299038-e0nsol3y 129 15 Sia Sia NNP cord-299038-e0nsol3y 129 16 of of IN cord-299038-e0nsol3y 129 17 GBS GBS NNP cord-299038-e0nsol3y 129 18 and and CC cord-299038-e0nsol3y 129 19 HA HA NNP cord-299038-e0nsol3y 129 20 of of IN cord-299038-e0nsol3y 129 21 GAS gas NN cord-299038-e0nsol3y 129 22 , , , cord-299038-e0nsol3y 129 23 each each DT cord-299038-e0nsol3y 129 24 target target VBP cord-299038-e0nsol3y 129 25 distinct distinct JJ cord-299038-e0nsol3y 129 26 epitopes epitope NNS cord-299038-e0nsol3y 129 27 in in IN cord-299038-e0nsol3y 129 28 the the DT cord-299038-e0nsol3y 129 29 V v NN cord-299038-e0nsol3y 129 30 - - HYPH cord-299038-e0nsol3y 129 31 set set NN cord-299038-e0nsol3y 129 32 domain domain NN cord-299038-e0nsol3y 129 33 of of IN cord-299038-e0nsol3y 129 34 inhibitory inhibitory JJ cord-299038-e0nsol3y 129 35 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 129 36 to to TO cord-299038-e0nsol3y 129 37 dampen dampen VB cord-299038-e0nsol3y 129 38 immune immune JJ cord-299038-e0nsol3y 129 39 responses response NNS cord-299038-e0nsol3y 129 40 and and CC cord-299038-e0nsol3y 129 41 promote promote VB cord-299038-e0nsol3y 129 42 pathogen pathogen NN cord-299038-e0nsol3y 129 43 survival survival NN cord-299038-e0nsol3y 129 44 in in IN cord-299038-e0nsol3y 129 45 the the DT cord-299038-e0nsol3y 129 46 human human JJ cord-299038-e0nsol3y 129 47 host host NN cord-299038-e0nsol3y 129 48 ( ( -LRB- cord-299038-e0nsol3y 129 49 Secundino Secundino NNP cord-299038-e0nsol3y 129 50 et et NNP cord-299038-e0nsol3y 129 51 al al NNP cord-299038-e0nsol3y 129 52 . . . cord-299038-e0nsol3y 129 53 2016 2016 CD cord-299038-e0nsol3y 129 54 ) ) -RRB- cord-299038-e0nsol3y 129 55 . . . cord-299038-e0nsol3y 130 1 Although although IN cord-299038-e0nsol3y 130 2 fundamentally fundamentally RB cord-299038-e0nsol3y 130 3 distinct distinct JJ cord-299038-e0nsol3y 130 4 from from IN cord-299038-e0nsol3y 130 5 the the DT cord-299038-e0nsol3y 130 6 Sia Sia NNP cord-299038-e0nsol3y 130 7 molecular molecular JJ cord-299038-e0nsol3y 130 8 mimicry mimicry NN cord-299038-e0nsol3y 130 9 strategies strategy NNS cord-299038-e0nsol3y 130 10 employed employ VBN cord-299038-e0nsol3y 130 11 by by IN cord-299038-e0nsol3y 130 12 bacterial bacterial JJ cord-299038-e0nsol3y 130 13 pathogens pathogen NNS cord-299038-e0nsol3y 130 14 to to TO cord-299038-e0nsol3y 130 15 engage engage VB cord-299038-e0nsol3y 130 16 inhibitory inhibitory JJ cord-299038-e0nsol3y 130 17 Siglecs Siglecs NNP cord-299038-e0nsol3y 130 18 for for IN cord-299038-e0nsol3y 130 19 immune immune JJ cord-299038-e0nsol3y 130 20 evasion evasion NN cord-299038-e0nsol3y 130 21 , , , cord-299038-e0nsol3y 130 22 several several JJ cord-299038-e0nsol3y 130 23 lines line NNS cord-299038-e0nsol3y 130 24 of of IN cord-299038-e0nsol3y 130 25 evidence evidence NN cord-299038-e0nsol3y 130 26 indicate indicate VBP cord-299038-e0nsol3y 130 27 viruses virus NNS cord-299038-e0nsol3y 130 28 can can MD cord-299038-e0nsol3y 130 29 themselves -PRON- PRP cord-299038-e0nsol3y 130 30 take take VB cord-299038-e0nsol3y 130 31 advantage advantage NN cord-299038-e0nsol3y 130 32 of of IN cord-299038-e0nsol3y 130 33 Sia Sia NNP cord-299038-e0nsol3y 130 34 - - HYPH cord-299038-e0nsol3y 130 35 Siglec Siglec NNP cord-299038-e0nsol3y 130 36 interactions interaction NNS cord-299038-e0nsol3y 130 37 for for IN cord-299038-e0nsol3y 130 38 cell cell NN cord-299038-e0nsol3y 130 39 targeting targeting NN cord-299038-e0nsol3y 130 40 , , , cord-299038-e0nsol3y 130 41 spreading spread VBG cord-299038-e0nsol3y 130 42 , , , cord-299038-e0nsol3y 130 43 and and CC cord-299038-e0nsol3y 130 44 trans trans NN cord-299038-e0nsol3y 130 45 - - NN cord-299038-e0nsol3y 130 46 infection infection NN cord-299038-e0nsol3y 130 47 . . . cord-299038-e0nsol3y 131 1 Human human JJ cord-299038-e0nsol3y 131 2 immunodeficiency immunodeficiency NN cord-299038-e0nsol3y 131 3 virus-1 virus-1 NN cord-299038-e0nsol3y 131 4 ( ( -LRB- cord-299038-e0nsol3y 131 5 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 131 6 ) ) -RRB- cord-299038-e0nsol3y 131 7 exploits exploit VBZ cord-299038-e0nsol3y 131 8 a a DT cord-299038-e0nsol3y 131 9 Sia Sia NNP cord-299038-e0nsol3y 131 10 - - HYPH cord-299038-e0nsol3y 131 11 Siglec Siglec NNP cord-299038-e0nsol3y 131 12 axis axis NN cord-299038-e0nsol3y 131 13 to to TO cord-299038-e0nsol3y 131 14 facilitate facilitate VB cord-299038-e0nsol3y 131 15 its -PRON- PRP$ cord-299038-e0nsol3y 131 16 entry entry NN cord-299038-e0nsol3y 131 17 into into IN cord-299038-e0nsol3y 131 18 myeloid myeloid JJ cord-299038-e0nsol3y 131 19 cells cell NNS cord-299038-e0nsol3y 131 20 and and CC cord-299038-e0nsol3y 131 21 trans tran NNS cord-299038-e0nsol3y 131 22 - - NN cord-299038-e0nsol3y 131 23 infection infection NN cord-299038-e0nsol3y 131 24 into into IN cord-299038-e0nsol3y 131 25 CD4 CD4 NNP cord-299038-e0nsol3y 131 26 + + CC cord-299038-e0nsol3y 131 27 T t NN cord-299038-e0nsol3y 131 28 cells cell NNS cord-299038-e0nsol3y 131 29 . . . cord-299038-e0nsol3y 132 1 Notably notably RB cord-299038-e0nsol3y 132 2 , , , cord-299038-e0nsol3y 132 3 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 132 4 possesses possess VBZ cord-299038-e0nsol3y 132 5 a a DT cord-299038-e0nsol3y 132 6 unique unique JJ cord-299038-e0nsol3y 132 7 extended extend VBN cord-299038-e0nsol3y 132 8 17 17 CD cord-299038-e0nsol3y 132 9 Ig Ig NNP cord-299038-e0nsol3y 132 10 - - HYPH cord-299038-e0nsol3y 132 11 like like JJ cord-299038-e0nsol3y 132 12 extracellular extracellular JJ cord-299038-e0nsol3y 132 13 domain domain NN cord-299038-e0nsol3y 132 14 structure structure NN cord-299038-e0nsol3y 132 15 extending extend VBG cord-299038-e0nsol3y 132 16 out out RP cord-299038-e0nsol3y 132 17 from from IN cord-299038-e0nsol3y 132 18 the the DT cord-299038-e0nsol3y 132 19 surface surface NN cord-299038-e0nsol3y 132 20 glycocalyx glycocalyx NNP cord-299038-e0nsol3y 132 21 in in IN cord-299038-e0nsol3y 132 22 an an DT cord-299038-e0nsol3y 132 23 un un JJ cord-299038-e0nsol3y 132 24 - - JJ cord-299038-e0nsol3y 132 25 masked masked JJ cord-299038-e0nsol3y 132 26 state state NN cord-299038-e0nsol3y 132 27 which which WDT cord-299038-e0nsol3y 132 28 makes make VBZ cord-299038-e0nsol3y 132 29 it -PRON- PRP cord-299038-e0nsol3y 132 30 an an DT cord-299038-e0nsol3y 132 31 ideal ideal JJ cord-299038-e0nsol3y 132 32 surface surface NN cord-299038-e0nsol3y 132 33 entry entry NN cord-299038-e0nsol3y 132 34 target target NN cord-299038-e0nsol3y 132 35 . . . cord-299038-e0nsol3y 133 1 Moreover moreover RB cord-299038-e0nsol3y 133 2 , , , cord-299038-e0nsol3y 133 3 in in IN cord-299038-e0nsol3y 133 4 contrast contrast NN cord-299038-e0nsol3y 133 5 to to IN cord-299038-e0nsol3y 133 6 infected infected JJ cord-299038-e0nsol3y 133 7 CD4 CD4 NNP cord-299038-e0nsol3y 133 8 + + CC cord-299038-e0nsol3y 133 9 T t NN cord-299038-e0nsol3y 133 10 cells cell NNS cord-299038-e0nsol3y 133 11 , , , cord-299038-e0nsol3y 133 12 myeloid myeloid NN cord-299038-e0nsol3y 133 13 cells cell NNS cord-299038-e0nsol3y 133 14 are be VBP cord-299038-e0nsol3y 133 15 relatively relatively RB cord-299038-e0nsol3y 133 16 resistant resistant JJ cord-299038-e0nsol3y 133 17 to to IN cord-299038-e0nsol3y 133 18 HIV-1-induced hiv-1-induce VBN cord-299038-e0nsol3y 133 19 cytopathic cytopathic JJ cord-299038-e0nsol3y 133 20 effects effect NNS cord-299038-e0nsol3y 133 21 and and CC cord-299038-e0nsol3y 133 22 there there EX cord-299038-e0nsol3y 133 23 is be VBZ cord-299038-e0nsol3y 133 24 no no DT cord-299038-e0nsol3y 133 25 obvious obvious JJ cord-299038-e0nsol3y 133 26 depletion depletion NN cord-299038-e0nsol3y 133 27 of of IN cord-299038-e0nsol3y 133 28 myeloid myeloid NN cord-299038-e0nsol3y 133 29 cells cell NNS cord-299038-e0nsol3y 133 30 in in IN cord-299038-e0nsol3y 133 31 HIV-1-infected hiv-1-infecte VBN cord-299038-e0nsol3y 133 32 patients patient NNS cord-299038-e0nsol3y 133 33 . . . cord-299038-e0nsol3y 134 1 To to TO cord-299038-e0nsol3y 134 2 escape escape VB cord-299038-e0nsol3y 134 3 from from IN cord-299038-e0nsol3y 134 4 host host NN cord-299038-e0nsol3y 134 5 immune immune JJ cord-299038-e0nsol3y 134 6 surveillance surveillance NN cord-299038-e0nsol3y 134 7 , , , cord-299038-e0nsol3y 134 8 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 134 9 may may MD cord-299038-e0nsol3y 134 10 have have VB cord-299038-e0nsol3y 134 11 evolved evolve VBN cord-299038-e0nsol3y 134 12 to to TO cord-299038-e0nsol3y 134 13 hijack hijack VB cord-299038-e0nsol3y 134 14 this this DT cord-299038-e0nsol3y 134 15 Siglec-1-mediated siglec-1-mediated JJ cord-299038-e0nsol3y 134 16 cellular cellular JJ cord-299038-e0nsol3y 134 17 recognition recognition NN cord-299038-e0nsol3y 134 18 pathway pathway NN cord-299038-e0nsol3y 134 19 for for IN cord-299038-e0nsol3y 134 20 its -PRON- PRP$ cord-299038-e0nsol3y 134 21 own own JJ cord-299038-e0nsol3y 134 22 benefit benefit NN cord-299038-e0nsol3y 134 23 , , , cord-299038-e0nsol3y 134 24 to to TO cord-299038-e0nsol3y 134 25 hide hide VB cord-299038-e0nsol3y 134 26 within within IN cord-299038-e0nsol3y 134 27 infected infected JJ cord-299038-e0nsol3y 134 28 macrophages macrophage NNS cord-299038-e0nsol3y 134 29 and and CC cord-299038-e0nsol3y 134 30 trans tran NNS cord-299038-e0nsol3y 134 31 - - NN cord-299038-e0nsol3y 134 32 infect infect VB cord-299038-e0nsol3y 135 1 CD4 CD4 NNP cord-299038-e0nsol3y 135 2 + + CC cord-299038-e0nsol3y 135 3 T t NN cord-299038-e0nsol3y 135 4 cells cell NNS cord-299038-e0nsol3y 135 5 for for IN cord-299038-e0nsol3y 135 6 efficient efficient JJ cord-299038-e0nsol3y 135 7 viral viral JJ cord-299038-e0nsol3y 135 8 spread spread NN cord-299038-e0nsol3y 135 9 . . . cord-299038-e0nsol3y 136 1 In in IN cord-299038-e0nsol3y 136 2 the the DT cord-299038-e0nsol3y 136 3 manner manner NN cord-299038-e0nsol3y 136 4 of of IN cord-299038-e0nsol3y 136 5 many many JJ cord-299038-e0nsol3y 136 6 enveloped envelop VBN cord-299038-e0nsol3y 136 7 retroviruses retrovirus NNS cord-299038-e0nsol3y 136 8 , , , cord-299038-e0nsol3y 136 9 the the DT cord-299038-e0nsol3y 136 10 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 136 11 envelope envelope NN cord-299038-e0nsol3y 136 12 glycoprotein glycoprotein NN cord-299038-e0nsol3y 136 13 gp120 gp120 NNP cord-299038-e0nsol3y 136 14 is be VBZ cord-299038-e0nsol3y 136 15 heavily heavily RB cord-299038-e0nsol3y 136 16 glycosylated glycosylate VBN cord-299038-e0nsol3y 136 17 , , , cord-299038-e0nsol3y 136 18 and and CC cord-299038-e0nsol3y 136 19 gp120 gp120 NNP cord-299038-e0nsol3y 136 20 mutations mutation NNS cord-299038-e0nsol3y 136 21 that that WDT cord-299038-e0nsol3y 136 22 remove remove VBP cord-299038-e0nsol3y 136 23 N n CD cord-299038-e0nsol3y 136 24 - - HYPH cord-299038-e0nsol3y 136 25 linked link VBN cord-299038-e0nsol3y 136 26 glycan glycan NN cord-299038-e0nsol3y 136 27 sites site NNS cord-299038-e0nsol3y 136 28 on on IN cord-299038-e0nsol3y 136 29 HIV HIV NNP cord-299038-e0nsol3y 136 30 ( ( -LRB- cord-299038-e0nsol3y 136 31 and and CC cord-299038-e0nsol3y 136 32 simian simian JJ cord-299038-e0nsol3y 136 33 immunodeficiency immunodeficiency NN cord-299038-e0nsol3y 136 34 virus virus NN cord-299038-e0nsol3y 136 35 SIV SIV NNP cord-299038-e0nsol3y 136 36 ) ) -RRB- cord-299038-e0nsol3y 136 37 impair impair VBP cord-299038-e0nsol3y 136 38 virus virus NN cord-299038-e0nsol3y 136 39 attachment attachment NN cord-299038-e0nsol3y 136 40 and and CC cord-299038-e0nsol3y 136 41 entry entry NN cord-299038-e0nsol3y 137 1 ( ( -LRB- cord-299038-e0nsol3y 137 2 Auwerx Auwerx NNP cord-299038-e0nsol3y 137 3 et et NNP cord-299038-e0nsol3y 137 4 al al NNP cord-299038-e0nsol3y 137 5 . . NNP cord-299038-e0nsol3y 137 6 2008 2008 CD cord-299038-e0nsol3y 137 7 ) ) -RRB- cord-299038-e0nsol3y 137 8 . . . cord-299038-e0nsol3y 138 1 A a DT cord-299038-e0nsol3y 138 2 direct direct JJ cord-299038-e0nsol3y 138 3 interaction interaction NN cord-299038-e0nsol3y 138 4 of of IN cord-299038-e0nsol3y 138 5 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 138 6 and and CC cord-299038-e0nsol3y 139 1 Siglec Siglec NNP cord-299038-e0nsol3y 139 2 was be VBD cord-299038-e0nsol3y 139 3 first first RB cord-299038-e0nsol3y 139 4 reported report VBN cord-299038-e0nsol3y 139 5 by by IN cord-299038-e0nsol3y 139 6 Rempel Rempel NNP cord-299038-e0nsol3y 139 7 et et FW cord-299038-e0nsol3y 139 8 al al NNP cord-299038-e0nsol3y 139 9 . . . cord-299038-e0nsol3y 140 1 in in IN cord-299038-e0nsol3y 140 2 2008 2008 CD cord-299038-e0nsol3y 140 3 , , , cord-299038-e0nsol3y 140 4 where where WRB cord-299038-e0nsol3y 140 5 expression expression NN cord-299038-e0nsol3y 140 6 levels level NNS cord-299038-e0nsol3y 140 7 of of IN cord-299038-e0nsol3y 140 8 Siglec-1 Siglec-1 NNPS cord-299038-e0nsol3y 140 9 were be VBD cord-299038-e0nsol3y 140 10 correlated correlate VBN cord-299038-e0nsol3y 140 11 to to IN cord-299038-e0nsol3y 140 12 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 140 13 viral viral JJ cord-299038-e0nsol3y 140 14 load load NN cord-299038-e0nsol3y 140 15 , , , cord-299038-e0nsol3y 140 16 and and CC cord-299038-e0nsol3y 140 17 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 140 18 was be VBD cord-299038-e0nsol3y 140 19 proven prove VBN cord-299038-e0nsol3y 140 20 to to TO cord-299038-e0nsol3y 140 21 bind bind VB cord-299038-e0nsol3y 140 22 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 140 23 in in IN cord-299038-e0nsol3y 140 24 a a DT cord-299038-e0nsol3y 140 25 Sia Sia NNP cord-299038-e0nsol3y 140 26 - - HYPH cord-299038-e0nsol3y 140 27 dependent dependent JJ cord-299038-e0nsol3y 140 28 manner manner NN cord-299038-e0nsol3y 140 29 and and CC cord-299038-e0nsol3y 140 30 facilitate facilitate VB cord-299038-e0nsol3y 140 31 infection infection NN cord-299038-e0nsol3y 140 32 to to IN cord-299038-e0nsol3y 140 33 a a DT cord-299038-e0nsol3y 140 34 permissive permissive JJ cord-299038-e0nsol3y 140 35 reporter reporter NN cord-299038-e0nsol3y 140 36 cell cell NN cord-299038-e0nsol3y 140 37 line line NN cord-299038-e0nsol3y 140 38 ( ( -LRB- cord-299038-e0nsol3y 140 39 Rempel Rempel NNP cord-299038-e0nsol3y 140 40 et et NNP cord-299038-e0nsol3y 140 41 al al NNP cord-299038-e0nsol3y 140 42 . . NNP cord-299038-e0nsol3y 140 43 2008 2008 CD cord-299038-e0nsol3y 140 44 ) ) -RRB- cord-299038-e0nsol3y 140 45 . . . cord-299038-e0nsol3y 141 1 Later later RB cord-299038-e0nsol3y 141 2 gp120 gp120 NNP cord-299038-e0nsol3y 141 3 was be VBD cord-299038-e0nsol3y 141 4 proven prove VBN cord-299038-e0nsol3y 141 5 to to TO cord-299038-e0nsol3y 141 6 serve serve VB cord-299038-e0nsol3y 141 7 as as IN cord-299038-e0nsol3y 141 8 viral viral JJ cord-299038-e0nsol3y 141 9 ligand ligand NN cord-299038-e0nsol3y 141 10 for for IN cord-299038-e0nsol3y 141 11 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 141 12 and and CC cord-299038-e0nsol3y 141 13 for for IN cord-299038-e0nsol3y 141 14 several several JJ cord-299038-e0nsol3y 141 15 CD33rSigecs cd33rsigecs NN cord-299038-e0nsol3y 141 16 , , , cord-299038-e0nsol3y 141 17 including include VBG cord-299038-e0nsol3y 141 18 Siglec-3 Siglec-3 NNP cord-299038-e0nsol3y 141 19 , , , cord-299038-e0nsol3y 141 20 -5 -5 NNP cord-299038-e0nsol3y 141 21 , , , cord-299038-e0nsol3y 141 22 -7 -7 NNP cord-299038-e0nsol3y 141 23 , , , cord-299038-e0nsol3y 141 24 and and CC cord-299038-e0nsol3y 141 25 -9 -9 ADD cord-299038-e0nsol3y 141 26 , , , cord-299038-e0nsol3y 141 27 with with IN cord-299038-e0nsol3y 141 28 varying vary VBG cord-299038-e0nsol3y 141 29 avidity avidity NN cord-299038-e0nsol3y 141 30 and and CC cord-299038-e0nsol3y 141 31 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 141 32 strain strain VB cord-299038-e0nsol3y 141 33 dependency dependency NN cord-299038-e0nsol3y 141 34 . . . cord-299038-e0nsol3y 142 1 Moreover moreover RB cord-299038-e0nsol3y 142 2 , , , cord-299038-e0nsol3y 142 3 this this DT cord-299038-e0nsol3y 142 4 Siglec Siglec NNP cord-299038-e0nsol3y 142 5 - - HYPH cord-299038-e0nsol3y 142 6 gp120 gp120 NNP cord-299038-e0nsol3y 142 7 interaction interaction NN cord-299038-e0nsol3y 142 8 facilitates facilitate VBZ cord-299038-e0nsol3y 142 9 virus virus NN cord-299038-e0nsol3y 142 10 infectivity infectivity NN cord-299038-e0nsol3y 142 11 to to IN cord-299038-e0nsol3y 142 12 macrophages macrophage NNS cord-299038-e0nsol3y 142 13 and and CC cord-299038-e0nsol3y 142 14 T t NN cord-299038-e0nsol3y 142 15 cells cell NNS cord-299038-e0nsol3y 142 16 ( ( -LRB- cord-299038-e0nsol3y 142 17 Zou Zou NNP cord-299038-e0nsol3y 142 18 et et FW cord-299038-e0nsol3y 142 19 al al NNP cord-299038-e0nsol3y 142 20 . . . cord-299038-e0nsol3y 143 1 2011 2011 CD cord-299038-e0nsol3y 143 2 ; ; : cord-299038-e0nsol3y 143 3 Varchetta Varchetta NNP cord-299038-e0nsol3y 143 4 et et NNP cord-299038-e0nsol3y 143 5 al al NNP cord-299038-e0nsol3y 143 6 . . NNP cord-299038-e0nsol3y 143 7 2013 2013 CD cord-299038-e0nsol3y 143 8 ) ) -RRB- cord-299038-e0nsol3y 143 9 . . . cord-299038-e0nsol3y 144 1 Mature mature JJ cord-299038-e0nsol3y 144 2 DCs dc NNS cord-299038-e0nsol3y 144 3 ( ( -LRB- cord-299038-e0nsol3y 144 4 mDCs mDCs NNP cord-299038-e0nsol3y 144 5 ) ) -RRB- cord-299038-e0nsol3y 144 6 capture capture VB cord-299038-e0nsol3y 144 7 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 144 8 and and CC cord-299038-e0nsol3y 144 9 viral viral JJ cord-299038-e0nsol3y 144 10 membrane membrane NN cord-299038-e0nsol3y 144 11 gangliosides ganglioside NNS cord-299038-e0nsol3y 144 12 , , , cord-299038-e0nsol3y 144 13 then then RB cord-299038-e0nsol3y 144 14 transfer transfer VB cord-299038-e0nsol3y 144 15 the the DT cord-299038-e0nsol3y 144 16 virus virus NN cord-299038-e0nsol3y 144 17 to to IN cord-299038-e0nsol3y 144 18 bystander bystander NN cord-299038-e0nsol3y 144 19 CD4 CD4 NNP cord-299038-e0nsol3y 144 20 + + CC cord-299038-e0nsol3y 144 21 T t NN cord-299038-e0nsol3y 144 22 cells cell NNS cord-299038-e0nsol3y 144 23 via via IN cord-299038-e0nsol3y 144 24 the the DT cord-299038-e0nsol3y 144 25 established establish VBN cord-299038-e0nsol3y 144 26 immunological immunological JJ cord-299038-e0nsol3y 144 27 synapses synapsis NNS cord-299038-e0nsol3y 144 28 between between IN cord-299038-e0nsol3y 144 29 these these DT cord-299038-e0nsol3y 144 30 two two CD cord-299038-e0nsol3y 144 31 immune immune JJ cord-299038-e0nsol3y 144 32 cell cell NN cord-299038-e0nsol3y 144 33 types type NNS cord-299038-e0nsol3y 144 34 . . . cord-299038-e0nsol3y 145 1 Host host NN cord-299038-e0nsol3y 145 2 cellderived cellderived NNP cord-299038-e0nsol3y 145 3 α2,3 α2,3 JJ cord-299038-e0nsol3y 145 4 sialylated sialylated JJ cord-299038-e0nsol3y 145 5 glycosphingolipid glycosphingolipid NNP cord-299038-e0nsol3y 145 6 ( ( -LRB- cord-299038-e0nsol3y 145 7 GSL GSL NNP cord-299038-e0nsol3y 145 8 ) ) -RRB- cord-299038-e0nsol3y 145 9 on on IN cord-299038-e0nsol3y 145 10 the the DT cord-299038-e0nsol3y 145 11 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 145 12 particle particle NN cord-299038-e0nsol3y 145 13 membrane membrane NN cord-299038-e0nsol3y 145 14 is be VBZ cord-299038-e0nsol3y 145 15 the the DT cord-299038-e0nsol3y 145 16 ligand ligand NN cord-299038-e0nsol3y 145 17 for for IN cord-299038-e0nsol3y 145 18 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 145 19 on on IN cord-299038-e0nsol3y 145 20 mDC mDC NNS cord-299038-e0nsol3y 145 21 required require VBN cord-299038-e0nsol3y 145 22 for for IN cord-299038-e0nsol3y 145 23 triggering trigger VBG cord-299038-e0nsol3y 145 24 mDC mdc NN cord-299038-e0nsol3y 145 25 - - HYPH cord-299038-e0nsol3y 145 26 mediated mediate VBN cord-299038-e0nsol3y 145 27 transinfection transinfection NN cord-299038-e0nsol3y 145 28 of of IN cord-299038-e0nsol3y 145 29 CD4 CD4 NNP cord-299038-e0nsol3y 145 30 + + CC cord-299038-e0nsol3y 145 31 T T NNP cord-299038-e0nsol3y 145 32 cells cell NNS cord-299038-e0nsol3y 145 33 in in IN cord-299038-e0nsol3y 145 34 lymphoid lymphoid JJ cord-299038-e0nsol3y 145 35 organs organ NNS cord-299038-e0nsol3y 146 1 ( ( -LRB- cord-299038-e0nsol3y 146 2 Yu Yu NNP cord-299038-e0nsol3y 146 3 et et FW cord-299038-e0nsol3y 146 4 al al NNP cord-299038-e0nsol3y 146 5 . . . cord-299038-e0nsol3y 147 1 2014 2014 CD cord-299038-e0nsol3y 147 2 ; ; : cord-299038-e0nsol3y 147 3 Izquierdo Izquierdo NNP cord-299038-e0nsol3y 147 4 - - HYPH cord-299038-e0nsol3y 147 5 Useros Useros NNP cord-299038-e0nsol3y 147 6 et et NNP cord-299038-e0nsol3y 147 7 al al NNP cord-299038-e0nsol3y 147 8 . . . cord-299038-e0nsol3y 148 1 2012 2012 CD cord-299038-e0nsol3y 148 2 ; ; : cord-299038-e0nsol3y 148 3 Puryear Puryear NNP cord-299038-e0nsol3y 148 4 et et NNP cord-299038-e0nsol3y 148 5 al al NNP cord-299038-e0nsol3y 148 6 . . NNP cord-299038-e0nsol3y 148 7 2013 2013 CD cord-299038-e0nsol3y 148 8 ) ) -RRB- cord-299038-e0nsol3y 148 9 . . . cord-299038-e0nsol3y 149 1 A a DT cord-299038-e0nsol3y 149 2 population population NN cord-299038-e0nsol3y 149 3 of of IN cord-299038-e0nsol3y 149 4 cervical cervical JJ cord-299038-e0nsol3y 149 5 DCs dc NNS cord-299038-e0nsol3y 149 6 at at IN cord-299038-e0nsol3y 149 7 the the DT cord-299038-e0nsol3y 149 8 lamina lamina JJ cord-299038-e0nsol3y 149 9 propria propria NN cord-299038-e0nsol3y 149 10 of of IN cord-299038-e0nsol3y 149 11 the the DT cord-299038-e0nsol3y 149 12 ectocervix ectocervix NN cord-299038-e0nsol3y 149 13 and and CC cord-299038-e0nsol3y 149 14 the the DT cord-299038-e0nsol3y 149 15 endocervix endocervix NNP cord-299038-e0nsol3y 149 16 that that WDT cord-299038-e0nsol3y 149 17 express express VBP cord-299038-e0nsol3y 149 18 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 149 19 may may MD cord-299038-e0nsol3y 149 20 be be VB cord-299038-e0nsol3y 149 21 particularly particularly RB cord-299038-e0nsol3y 149 22 important important JJ cord-299038-e0nsol3y 149 23 , , , cord-299038-e0nsol3y 149 24 and and CC cord-299038-e0nsol3y 149 25 ex ex FW cord-299038-e0nsol3y 149 26 vivo vivo NN cord-299038-e0nsol3y 149 27 studies study NNS cord-299038-e0nsol3y 149 28 suggest suggest VBP cord-299038-e0nsol3y 149 29 that that IN cord-299038-e0nsol3y 149 30 CD4 CD4 NNP cord-299038-e0nsol3y 149 31 + + CC cord-299038-e0nsol3y 149 32 T t NN cord-299038-e0nsol3y 149 33 cell cell NN cord-299038-e0nsol3y 149 34 trans trans NN cord-299038-e0nsol3y 149 35 - - NN cord-299038-e0nsol3y 149 36 infection infection NN cord-299038-e0nsol3y 149 37 from from IN cord-299038-e0nsol3y 149 38 these these DT cord-299038-e0nsol3y 149 39 cells cell NNS cord-299038-e0nsol3y 149 40 can can MD cord-299038-e0nsol3y 149 41 be be VB cord-299038-e0nsol3y 149 42 blocked block VBN cord-299038-e0nsol3y 149 43 by by IN cord-299038-e0nsol3y 149 44 addition addition NN cord-299038-e0nsol3y 149 45 of of IN cord-299038-e0nsol3y 149 46 anti anti JJ cord-299038-e0nsol3y 149 47 - - JJ cord-299038-e0nsol3y 149 48 Siglec-1 siglec-1 JJ cord-299038-e0nsol3y 149 49 antibodies antibody NNS cord-299038-e0nsol3y 149 50 ( ( -LRB- cord-299038-e0nsol3y 149 51 Perez Perez NNP cord-299038-e0nsol3y 149 52 - - HYPH cord-299038-e0nsol3y 149 53 Zsolt Zsolt NNP cord-299038-e0nsol3y 149 54 et et NNP cord-299038-e0nsol3y 149 55 al al NNP cord-299038-e0nsol3y 149 56 . . NNP cord-299038-e0nsol3y 149 57 2019a 2019a CD cord-299038-e0nsol3y 149 58 ) ) -RRB- cord-299038-e0nsol3y 149 59 . . . cord-299038-e0nsol3y 150 1 A a DT cord-299038-e0nsol3y 150 2 loss loss NN cord-299038-e0nsol3y 150 3 - - HYPH cord-299038-e0nsol3y 150 4 of of IN cord-299038-e0nsol3y 150 5 - - HYPH cord-299038-e0nsol3y 150 6 function function NN cord-299038-e0nsol3y 150 7 variant variant NN cord-299038-e0nsol3y 150 8 ( ( -LRB- cord-299038-e0nsol3y 150 9 Glu88Ter Glu88Ter NNP cord-299038-e0nsol3y 150 10 ) ) -RRB- cord-299038-e0nsol3y 150 11 of of IN cord-299038-e0nsol3y 150 12 SIGLEC1 siglec1 NN cord-299038-e0nsol3y 150 13 gene gene NN cord-299038-e0nsol3y 150 14 was be VBD cord-299038-e0nsol3y 150 15 recently recently RB cord-299038-e0nsol3y 150 16 identified identify VBN cord-299038-e0nsol3y 150 17 from from IN cord-299038-e0nsol3y 150 18 the the DT cord-299038-e0nsol3y 150 19 Exome Exome NNP cord-299038-e0nsol3y 150 20 Aggregation Aggregation NNP cord-299038-e0nsol3y 150 21 Consortium Consortium NNP cord-299038-e0nsol3y 150 22 genetic genetic JJ cord-299038-e0nsol3y 150 23 database database NN cord-299038-e0nsol3y 150 24 to to TO cord-299038-e0nsol3y 150 25 be be VB cord-299038-e0nsol3y 150 26 present present JJ cord-299038-e0nsol3y 150 27 in in IN cord-299038-e0nsol3y 150 28 1 1 CD cord-299038-e0nsol3y 150 29 % % NN cord-299038-e0nsol3y 150 30 of of IN cord-299038-e0nsol3y 150 31 the the DT cord-299038-e0nsol3y 150 32 human human JJ cord-299038-e0nsol3y 150 33 population population NN cord-299038-e0nsol3y 150 34 . . . cord-299038-e0nsol3y 151 1 Monocytes monocyte NNS cord-299038-e0nsol3y 151 2 isolated isolate VBN cord-299038-e0nsol3y 151 3 from from IN cord-299038-e0nsol3y 151 4 individuals individual NNS cord-299038-e0nsol3y 151 5 with with IN cord-299038-e0nsol3y 151 6 this this DT cord-299038-e0nsol3y 151 7 specific specific JJ cord-299038-e0nsol3y 151 8 variant variant NN cord-299038-e0nsol3y 151 9 completely completely RB cord-299038-e0nsol3y 151 10 lack lack VBP cord-299038-e0nsol3y 151 11 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 151 12 expression expression NN cord-299038-e0nsol3y 151 13 and and CC cord-299038-e0nsol3y 151 14 have have VBP cord-299038-e0nsol3y 151 15 reduced reduce VBN cord-299038-e0nsol3y 151 16 HIV HIV NNP cord-299038-e0nsol3y 151 17 capture capture NN cord-299038-e0nsol3y 151 18 and and CC cord-299038-e0nsol3y 151 19 transinfection transinfection NN cord-299038-e0nsol3y 151 20 phenotypes phenotype NNS cord-299038-e0nsol3y 151 21 ex ex NN cord-299038-e0nsol3y 151 22 vivo vivo NN cord-299038-e0nsol3y 151 23 . . . cord-299038-e0nsol3y 152 1 However however RB cord-299038-e0nsol3y 152 2 , , , cord-299038-e0nsol3y 152 3 individuals individual NNS cord-299038-e0nsol3y 152 4 carrying carry VBG cord-299038-e0nsol3y 152 5 this this DT cord-299038-e0nsol3y 152 6 truncated truncated JJ cord-299038-e0nsol3y 152 7 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 152 8 protein protein NN cord-299038-e0nsol3y 152 9 do do VBP cord-299038-e0nsol3y 152 10 not not RB cord-299038-e0nsol3y 152 11 show show VB cord-299038-e0nsol3y 152 12 marked marked JJ cord-299038-e0nsol3y 152 13 difference difference NN cord-299038-e0nsol3y 152 14 in in IN cord-299038-e0nsol3y 152 15 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 152 16 acquisition acquisition NN cord-299038-e0nsol3y 152 17 and and CC cord-299038-e0nsol3y 152 18 AIDS AIDS NNP cord-299038-e0nsol3y 152 19 outcomes outcome NNS cord-299038-e0nsol3y 152 20 in in IN cord-299038-e0nsol3y 152 21 vivo vivo NN cord-299038-e0nsol3y 152 22 , , , cord-299038-e0nsol3y 152 23 which which WDT cord-299038-e0nsol3y 152 24 suggests suggest VBZ cord-299038-e0nsol3y 152 25 an an DT cord-299038-e0nsol3y 152 26 indispensable indispensable JJ cord-299038-e0nsol3y 152 27 ( ( -LRB- cord-299038-e0nsol3y 152 28 and and CC cord-299038-e0nsol3y 152 29 perhaps perhaps RB cord-299038-e0nsol3y 152 30 dominant dominant JJ cord-299038-e0nsol3y 152 31 ) ) -RRB- cord-299038-e0nsol3y 152 32 role role NN cord-299038-e0nsol3y 152 33 of of IN cord-299038-e0nsol3y 152 34 the the DT cord-299038-e0nsol3y 152 35 classical classical JJ cord-299038-e0nsol3y 152 36 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 152 37 infectious infectious JJ cord-299038-e0nsol3y 152 38 routes route NNS cord-299038-e0nsol3y 152 39 in in IN cord-299038-e0nsol3y 152 40 the the DT cord-299038-e0nsol3y 152 41 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 152 42 dissemination dissemination NN cord-299038-e0nsol3y 152 43 within within IN cord-299038-e0nsol3y 152 44 the the DT cord-299038-e0nsol3y 152 45 infected infected JJ cord-299038-e0nsol3y 152 46 individuals individual NNS cord-299038-e0nsol3y 153 1 ( ( -LRB- cord-299038-e0nsol3y 153 2 Martinez Martinez NNP cord-299038-e0nsol3y 153 3 - - HYPH cord-299038-e0nsol3y 153 4 Picado Picado NNP cord-299038-e0nsol3y 153 5 et et FW cord-299038-e0nsol3y 153 6 al al NNP cord-299038-e0nsol3y 153 7 . . . cord-299038-e0nsol3y 153 8 2016 2016 CD cord-299038-e0nsol3y 153 9 ) ) -RRB- cord-299038-e0nsol3y 153 10 . . . cord-299038-e0nsol3y 154 1 The the DT cord-299038-e0nsol3y 154 2 importance importance NN cord-299038-e0nsol3y 154 3 of of IN cord-299038-e0nsol3y 154 4 Siglec-1-mediated siglec-1-mediated JJ cord-299038-e0nsol3y 154 5 viral viral JJ cord-299038-e0nsol3y 154 6 spreading spreading NN cord-299038-e0nsol3y 154 7 has have VBZ cord-299038-e0nsol3y 154 8 also also RB cord-299038-e0nsol3y 154 9 been be VBN cord-299038-e0nsol3y 154 10 confirmed confirm VBN cord-299038-e0nsol3y 154 11 in in IN cord-299038-e0nsol3y 154 12 vivo vivo NN cord-299038-e0nsol3y 154 13 in in IN cord-299038-e0nsol3y 154 14 murine murine JJ cord-299038-e0nsol3y 154 15 retroviral retroviral JJ cord-299038-e0nsol3y 154 16 infection infection NN cord-299038-e0nsol3y 154 17 models model NNS cord-299038-e0nsol3y 154 18 . . . cord-299038-e0nsol3y 155 1 Murine murine JJ cord-299038-e0nsol3y 155 2 leukemia leukemia NN cord-299038-e0nsol3y 155 3 virus virus NN cord-299038-e0nsol3y 155 4 ( ( -LRB- cord-299038-e0nsol3y 155 5 MLV MLV NNP cord-299038-e0nsol3y 155 6 ) ) -RRB- cord-299038-e0nsol3y 155 7 is be VBZ cord-299038-e0nsol3y 155 8 recognized recognize VBN cord-299038-e0nsol3y 155 9 by by IN cord-299038-e0nsol3y 155 10 murine murine JJ cord-299038-e0nsol3y 155 11 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 155 12 through through IN cord-299038-e0nsol3y 155 13 its -PRON- PRP$ cord-299038-e0nsol3y 155 14 sialylated sialylated JJ cord-299038-e0nsol3y 155 15 gangliosides ganglioside NNS cord-299038-e0nsol3y 155 16 ( ( -LRB- cord-299038-e0nsol3y 155 17 Erikson Erikson NNP cord-299038-e0nsol3y 155 18 et et NNP cord-299038-e0nsol3y 155 19 al al NNP cord-299038-e0nsol3y 155 20 . . . cord-299038-e0nsol3y 155 21 2015 2015 CD cord-299038-e0nsol3y 155 22 ; ; : cord-299038-e0nsol3y 155 23 Sewald Sewald NNP cord-299038-e0nsol3y 155 24 et et NNP cord-299038-e0nsol3y 155 25 al al NNP cord-299038-e0nsol3y 155 26 . . NNP cord-299038-e0nsol3y 155 27 2015 2015 CD cord-299038-e0nsol3y 155 28 ) ) -RRB- cord-299038-e0nsol3y 155 29 . . . cord-299038-e0nsol3y 156 1 MLV MLV NNP cord-299038-e0nsol3y 156 2 captured capture VBN cord-299038-e0nsol3y 156 3 by by IN cord-299038-e0nsol3y 156 4 Siglec-1-expressing siglec-1-expresse VBG cord-299038-e0nsol3y 156 5 sinus sinus NN cord-299038-e0nsol3y 156 6 - - HYPH cord-299038-e0nsol3y 156 7 lining line VBG cord-299038-e0nsol3y 156 8 macrophages macrophage NNS cord-299038-e0nsol3y 156 9 and and CC cord-299038-e0nsol3y 156 10 subsequent subsequent JJ cord-299038-e0nsol3y 156 11 trans trans NN cord-299038-e0nsol3y 156 12 - - NN cord-299038-e0nsol3y 156 13 infection infection NN cord-299038-e0nsol3y 156 14 into into IN cord-299038-e0nsol3y 156 15 B-1 B-1 NNP cord-299038-e0nsol3y 156 16 cells cell NNS cord-299038-e0nsol3y 156 17 through through IN cord-299038-e0nsol3y 156 18 their -PRON- PRP$ cord-299038-e0nsol3y 156 19 synaptic synaptic JJ cord-299038-e0nsol3y 156 20 contacts contact NNS cord-299038-e0nsol3y 156 21 was be VBD cord-299038-e0nsol3y 156 22 directly directly RB cord-299038-e0nsol3y 156 23 demonstrated demonstrate VBN cord-299038-e0nsol3y 156 24 by by IN cord-299038-e0nsol3y 156 25 time time NN cord-299038-e0nsol3y 156 26 - - HYPH cord-299038-e0nsol3y 156 27 lapse lapse NN cord-299038-e0nsol3y 156 28 intravital intravital NNP cord-299038-e0nsol3y 156 29 2-photon 2-photon CD cord-299038-e0nsol3y 156 30 laser laser NN cord-299038-e0nsol3y 156 31 scanning scanning NN cord-299038-e0nsol3y 156 32 microscopy microscopy NNS cord-299038-e0nsol3y 156 33 ( ( -LRB- cord-299038-e0nsol3y 156 34 Sewald Sewald NNP cord-299038-e0nsol3y 156 35 et et NNP cord-299038-e0nsol3y 156 36 al al NNP cord-299038-e0nsol3y 156 37 . . NNP cord-299038-e0nsol3y 156 38 2015 2015 CD cord-299038-e0nsol3y 156 39 ) ) -RRB- cord-299038-e0nsol3y 156 40 . . . cord-299038-e0nsol3y 157 1 Virus virus NN cord-299038-e0nsol3y 157 2 capture capture NN cord-299038-e0nsol3y 157 3 and and CC cord-299038-e0nsol3y 157 4 efficient efficient JJ cord-299038-e0nsol3y 157 5 MLV MLV NNP cord-299038-e0nsol3y 157 6 infection infection NN cord-299038-e0nsol3y 157 7 at at IN cord-299038-e0nsol3y 157 8 the the DT cord-299038-e0nsol3y 157 9 lymph lymph NN cord-299038-e0nsol3y 157 10 node node NN cord-299038-e0nsol3y 157 11 and and CC cord-299038-e0nsol3y 157 12 spleen spleen NNS cord-299038-e0nsol3y 157 13 were be VBD cord-299038-e0nsol3y 157 14 significantly significantly RB cord-299038-e0nsol3y 157 15 reduced reduce VBN cord-299038-e0nsol3y 157 16 by by IN cord-299038-e0nsol3y 157 17 Siglec-1-targeting Siglec-1-targeting NNP cord-299038-e0nsol3y 157 18 antibodies antibody NNS cord-299038-e0nsol3y 157 19 as as RB cord-299038-e0nsol3y 157 20 well well RB cord-299038-e0nsol3y 157 21 as as IN cord-299038-e0nsol3y 157 22 in in IN cord-299038-e0nsol3y 157 23 Siglec1 Siglec1 NNP cord-299038-e0nsol3y 157 24 −/ −/ NNP cord-299038-e0nsol3y 157 25 − − CD cord-299038-e0nsol3y 157 26 mice mouse NNS cord-299038-e0nsol3y 158 1 ( ( -LRB- cord-299038-e0nsol3y 158 2 Sewald Sewald NNP cord-299038-e0nsol3y 158 3 et et NNP cord-299038-e0nsol3y 158 4 al al NNP cord-299038-e0nsol3y 158 5 . . NNP cord-299038-e0nsol3y 158 6 2015 2015 CD cord-299038-e0nsol3y 158 7 ) ) -RRB- cord-299038-e0nsol3y 158 8 . . . cord-299038-e0nsol3y 159 1 These these DT cord-299038-e0nsol3y 159 2 data datum NNS cord-299038-e0nsol3y 159 3 confirm confirm VBP cord-299038-e0nsol3y 159 4 a a DT cord-299038-e0nsol3y 159 5 pivotal pivotal JJ cord-299038-e0nsol3y 159 6 role role NN cord-299038-e0nsol3y 159 7 of of IN cord-299038-e0nsol3y 159 8 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 159 9 in in IN cord-299038-e0nsol3y 159 10 initial initial JJ cord-299038-e0nsol3y 159 11 retroviral retroviral NN cord-299038-e0nsol3y 159 12 capture capture NN cord-299038-e0nsol3y 159 13 and and CC cord-299038-e0nsol3y 159 14 suggest suggest VBP cord-299038-e0nsol3y 159 15 that that IN cord-299038-e0nsol3y 159 16 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 159 17 could could MD cord-299038-e0nsol3y 159 18 represent represent VB cord-299038-e0nsol3y 159 19 a a DT cord-299038-e0nsol3y 159 20 therapeutic therapeutic JJ cord-299038-e0nsol3y 159 21 target target NN cord-299038-e0nsol3y 159 22 to to TO cord-299038-e0nsol3y 159 23 reduce reduce VB cord-299038-e0nsol3y 159 24 viral viral JJ cord-299038-e0nsol3y 159 25 laden laden JJ cord-299038-e0nsol3y 159 26 macrophage macrophage NN cord-299038-e0nsol3y 159 27 reservoirs reservoir NNS cord-299038-e0nsol3y 159 28 and and CC cord-299038-e0nsol3y 159 29 to to TO cord-299038-e0nsol3y 159 30 prevent prevent VB cord-299038-e0nsol3y 159 31 trans tran NNS cord-299038-e0nsol3y 159 32 - - NN cord-299038-e0nsol3y 159 33 infection infection NN cord-299038-e0nsol3y 159 34 . . . cord-299038-e0nsol3y 160 1 However however RB cord-299038-e0nsol3y 160 2 , , , cord-299038-e0nsol3y 160 3 in in IN cord-299038-e0nsol3y 160 4 a a DT cord-299038-e0nsol3y 160 5 murine murine JJ cord-299038-e0nsol3y 160 6 model model NN cord-299038-e0nsol3y 160 7 of of IN cord-299038-e0nsol3y 160 8 the the DT cord-299038-e0nsol3y 160 9 splenomegaly splenomegaly NN cord-299038-e0nsol3y 160 10 - - HYPH cord-299038-e0nsol3y 160 11 inducing induce VBG cord-299038-e0nsol3y 160 12 retrovirus retrovirus NN cord-299038-e0nsol3y 160 13 Friend friend NN cord-299038-e0nsol3y 160 14 virus virus NN cord-299038-e0nsol3y 160 15 complex complex NN cord-299038-e0nsol3y 160 16 ( ( -LRB- cord-299038-e0nsol3y 160 17 FVC fvc NN cord-299038-e0nsol3y 160 18 ) ) -RRB- cord-299038-e0nsol3y 160 19 infection infection NN cord-299038-e0nsol3y 160 20 , , , cord-299038-e0nsol3y 160 21 Siglec-1-expressing siglec-1-expressing NN cord-299038-e0nsol3y 160 22 macrophages macrophage NNS cord-299038-e0nsol3y 160 23 capture capture NN cord-299038-e0nsol3y 160 24 of of IN cord-299038-e0nsol3y 160 25 incoming incoming JJ cord-299038-e0nsol3y 160 26 blood blood NN cord-299038-e0nsol3y 160 27 - - HYPH cord-299038-e0nsol3y 160 28 borne bear VBN cord-299038-e0nsol3y 160 29 retroviruses retrovirus NNS cord-299038-e0nsol3y 160 30 limited limit VBD cord-299038-e0nsol3y 160 31 their -PRON- PRP$ cord-299038-e0nsol3y 160 32 spread spread NN cord-299038-e0nsol3y 160 33 to to IN cord-299038-e0nsol3y 160 34 erythroblasts erythroblast NNS cord-299038-e0nsol3y 160 35 in in IN cord-299038-e0nsol3y 160 36 the the DT cord-299038-e0nsol3y 160 37 red red JJ cord-299038-e0nsol3y 160 38 pulp pulp NN cord-299038-e0nsol3y 160 39 where where WRB cord-299038-e0nsol3y 160 40 FVC FVC NNP cord-299038-e0nsol3y 160 41 manifests manifest VBZ cord-299038-e0nsol3y 160 42 its -PRON- PRP$ cord-299038-e0nsol3y 160 43 pathogenesis pathogenesis NN cord-299038-e0nsol3y 160 44 ( ( -LRB- cord-299038-e0nsol3y 160 45 Uchil Uchil NNP cord-299038-e0nsol3y 160 46 et et NNP cord-299038-e0nsol3y 160 47 al al NNP cord-299038-e0nsol3y 160 48 . . . cord-299038-e0nsol3y 160 49 2019 2019 CD cord-299038-e0nsol3y 160 50 ) ) -RRB- cord-299038-e0nsol3y 160 51 . . . cord-299038-e0nsol3y 161 1 In in IN cord-299038-e0nsol3y 161 2 this this DT cord-299038-e0nsol3y 161 3 case case NN cord-299038-e0nsol3y 161 4 , , , cord-299038-e0nsol3y 161 5 Siglec-1-mediated Siglec-1-mediated NNP cord-299038-e0nsol3y 161 6 FVC FVC NNP cord-299038-e0nsol3y 161 7 capture capture NN cord-299038-e0nsol3y 161 8 was be VBD cord-299038-e0nsol3y 161 9 beneficial beneficial JJ cord-299038-e0nsol3y 161 10 , , , cord-299038-e0nsol3y 161 11 and and CC cord-299038-e0nsol3y 161 12 further further RB cord-299038-e0nsol3y 161 13 activated activate VBN cord-299038-e0nsol3y 161 14 DCs DCs NNP cord-299038-e0nsol3y 161 15 and and CC cord-299038-e0nsol3y 161 16 promoted promote VBD cord-299038-e0nsol3y 161 17 cytotoxic cytotoxic JJ cord-299038-e0nsol3y 161 18 CD8 CD8 NNP cord-299038-e0nsol3y 161 19 + + CC cord-299038-e0nsol3y 161 20 T T NNP cord-299038-e0nsol3y 161 21 cell cell NN cord-299038-e0nsol3y 161 22 responses response NNS cord-299038-e0nsol3y 161 23 , , , cord-299038-e0nsol3y 161 24 promoting promote VBG cord-299038-e0nsol3y 161 25 efficient efficient JJ cord-299038-e0nsol3y 161 26 clearing clearing NN cord-299038-e0nsol3y 161 27 of of IN cord-299038-e0nsol3y 161 28 FVC fvc NN cord-299038-e0nsol3y 161 29 - - HYPH cord-299038-e0nsol3y 161 30 infected infect VBN cord-299038-e0nsol3y 161 31 cells cell NNS cord-299038-e0nsol3y 162 1 ( ( -LRB- cord-299038-e0nsol3y 162 2 Uchil Uchil NNP cord-299038-e0nsol3y 162 3 et et NNP cord-299038-e0nsol3y 162 4 al al NNP cord-299038-e0nsol3y 162 5 . . . cord-299038-e0nsol3y 162 6 2019 2019 CD cord-299038-e0nsol3y 162 7 ) ) -RRB- cord-299038-e0nsol3y 162 8 . . . cord-299038-e0nsol3y 163 1 Another another DT cord-299038-e0nsol3y 163 2 well well RB cord-299038-e0nsol3y 163 3 - - HYPH cord-299038-e0nsol3y 163 4 documented document VBN cord-299038-e0nsol3y 163 5 example example NN cord-299038-e0nsol3y 163 6 of of IN cord-299038-e0nsol3y 163 7 Siglec Siglec NNP cord-299038-e0nsol3y 163 8 exploitation exploitation NN cord-299038-e0nsol3y 163 9 for for IN cord-299038-e0nsol3y 163 10 viral viral JJ cord-299038-e0nsol3y 163 11 entry entry NN cord-299038-e0nsol3y 163 12 and and CC cord-299038-e0nsol3y 163 13 immune immune JJ cord-299038-e0nsol3y 163 14 modulation modulation NN cord-299038-e0nsol3y 163 15 is be VBZ cord-299038-e0nsol3y 163 16 the the DT cord-299038-e0nsol3y 163 17 example example NN cord-299038-e0nsol3y 163 18 of of IN cord-299038-e0nsol3y 163 19 porcine porcine JJ cord-299038-e0nsol3y 163 20 reproductive reproductive JJ cord-299038-e0nsol3y 163 21 and and CC cord-299038-e0nsol3y 163 22 respiratory respiratory JJ cord-299038-e0nsol3y 163 23 syndrome syndrome NN cord-299038-e0nsol3y 163 24 virus virus NN cord-299038-e0nsol3y 163 25 ( ( -LRB- cord-299038-e0nsol3y 163 26 PRRSV PRRSV NNP cord-299038-e0nsol3y 163 27 ) ) -RRB- cord-299038-e0nsol3y 163 28 . . . cord-299038-e0nsol3y 164 1 PRRSV PRRSV NNP cord-299038-e0nsol3y 164 2 infection infection NN cord-299038-e0nsol3y 164 3 is be VBZ cord-299038-e0nsol3y 164 4 one one CD cord-299038-e0nsol3y 164 5 of of IN cord-299038-e0nsol3y 164 6 the the DT cord-299038-e0nsol3y 164 7 most most RBS cord-299038-e0nsol3y 164 8 economically economically RB cord-299038-e0nsol3y 164 9 devastating devastating JJ cord-299038-e0nsol3y 164 10 diseases disease NNS cord-299038-e0nsol3y 164 11 in in IN cord-299038-e0nsol3y 164 12 the the DT cord-299038-e0nsol3y 164 13 global global JJ cord-299038-e0nsol3y 164 14 pork pork NN cord-299038-e0nsol3y 164 15 industry industry NN cord-299038-e0nsol3y 164 16 . . . cord-299038-e0nsol3y 165 1 PRRSV PRRSV NNP cord-299038-e0nsol3y 165 2 has have VBZ cord-299038-e0nsol3y 165 3 a a DT cord-299038-e0nsol3y 165 4 narrow narrow JJ cord-299038-e0nsol3y 165 5 cell cell NN cord-299038-e0nsol3y 165 6 tropism tropism NN cord-299038-e0nsol3y 165 7 , , , cord-299038-e0nsol3y 165 8 primarily primarily RB cord-299038-e0nsol3y 165 9 targeting target VBG cord-299038-e0nsol3y 165 10 cells cell NNS cord-299038-e0nsol3y 165 11 of of IN cord-299038-e0nsol3y 165 12 the the DT cord-299038-e0nsol3y 165 13 monocyte monocyte NNP cord-299038-e0nsol3y 165 14 / / SYM cord-299038-e0nsol3y 165 15 macrophage macrophage NN cord-299038-e0nsol3y 165 16 lineage lineage NN cord-299038-e0nsol3y 165 17 ( ( -LRB- cord-299038-e0nsol3y 165 18 Duan Duan NNP cord-299038-e0nsol3y 165 19 et et FW cord-299038-e0nsol3y 165 20 al al NNP cord-299038-e0nsol3y 165 21 . . . cord-299038-e0nsol3y 165 22 1997 1997 CD cord-299038-e0nsol3y 165 23 ) ) -RRB- cord-299038-e0nsol3y 165 24 . . . cord-299038-e0nsol3y 166 1 Two two CD cord-299038-e0nsol3y 166 2 cellular cellular JJ cord-299038-e0nsol3y 166 3 proteins protein NNS cord-299038-e0nsol3y 166 4 , , , cord-299038-e0nsol3y 166 5 CD163 CD163 NNP cord-299038-e0nsol3y 166 6 and and CC cord-299038-e0nsol3y 166 7 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 166 8 have have VBP cord-299038-e0nsol3y 166 9 been be VBN cord-299038-e0nsol3y 166 10 identified identify VBN cord-299038-e0nsol3y 166 11 as as IN cord-299038-e0nsol3y 166 12 the the DT cord-299038-e0nsol3y 166 13 primary primary JJ cord-299038-e0nsol3y 166 14 targets target NNS cord-299038-e0nsol3y 166 15 for for IN cord-299038-e0nsol3y 166 16 PRRSV PRRSV NNP cord-299038-e0nsol3y 166 17 binding binding NN cord-299038-e0nsol3y 166 18 and and CC cord-299038-e0nsol3y 166 19 internalization internalization NN cord-299038-e0nsol3y 167 1 ( ( -LRB- cord-299038-e0nsol3y 167 2 Duan Duan NNP cord-299038-e0nsol3y 167 3 et et FW cord-299038-e0nsol3y 167 4 al al NNP cord-299038-e0nsol3y 167 5 . . . cord-299038-e0nsol3y 168 1 1998 1998 CD cord-299038-e0nsol3y 168 2 ; ; : cord-299038-e0nsol3y 168 3 Vanderheijden Vanderheijden NNP cord-299038-e0nsol3y 168 4 et et NNP cord-299038-e0nsol3y 168 5 al al NNP cord-299038-e0nsol3y 168 6 . . NNP cord-299038-e0nsol3y 168 7 2003 2003 CD cord-299038-e0nsol3y 168 8 ) ) -RRB- cord-299038-e0nsol3y 168 9 . . . cord-299038-e0nsol3y 169 1 α2 α2 NNP cord-299038-e0nsol3y 169 2 - - HYPH cord-299038-e0nsol3y 169 3 3 3 NNP cord-299038-e0nsol3y 169 4 and and CC cord-299038-e0nsol3y 169 5 , , , cord-299038-e0nsol3y 169 6 to to IN cord-299038-e0nsol3y 169 7 a a DT cord-299038-e0nsol3y 169 8 lesser less JJR cord-299038-e0nsol3y 169 9 extent extent NN cord-299038-e0nsol3y 169 10 , , , cord-299038-e0nsol3y 169 11 α2 α2 NNP cord-299038-e0nsol3y 169 12 - - HYPH cord-299038-e0nsol3y 169 13 6-linked 6-linked CD cord-299038-e0nsol3y 169 14 Sias Sias NNP cord-299038-e0nsol3y 169 15 on on IN cord-299038-e0nsol3y 169 16 the the DT cord-299038-e0nsol3y 169 17 PRRSV PRRSV NNP cord-299038-e0nsol3y 169 18 virion virion NN cord-299038-e0nsol3y 169 19 mediate mediate VBP cord-299038-e0nsol3y 169 20 viral viral JJ cord-299038-e0nsol3y 169 21 attachment attachment NN cord-299038-e0nsol3y 169 22 and and CC cord-299038-e0nsol3y 169 23 infection infection NN cord-299038-e0nsol3y 169 24 alveolar alveolar JJ cord-299038-e0nsol3y 169 25 macrophages macrophage NNS cord-299038-e0nsol3y 169 26 , , , cord-299038-e0nsol3y 169 27 with with IN cord-299038-e0nsol3y 169 28 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 169 29 serving serve VBG cord-299038-e0nsol3y 169 30 as as IN cord-299038-e0nsol3y 169 31 the the DT cord-299038-e0nsol3y 169 32 primary primary JJ cord-299038-e0nsol3y 169 33 entry entry NN cord-299038-e0nsol3y 169 34 receptor receptor NN cord-299038-e0nsol3y 169 35 responsible responsible JJ cord-299038-e0nsol3y 169 36 for for IN cord-299038-e0nsol3y 169 37 Sia Sia NNP cord-299038-e0nsol3y 169 38 - - JJ cord-299038-e0nsol3y 169 39 dependent dependent JJ cord-299038-e0nsol3y 169 40 binding bind VBG cord-299038-e0nsol3y 169 41 through through IN cord-299038-e0nsol3y 169 42 its -PRON- PRP$ cord-299038-e0nsol3y 169 43 N n CD cord-299038-e0nsol3y 169 44 - - HYPH cord-299038-e0nsol3y 169 45 terminal terminal NN cord-299038-e0nsol3y 169 46 V v NN cord-299038-e0nsol3y 169 47 - - HYPH cord-299038-e0nsol3y 169 48 set set NN cord-299038-e0nsol3y 169 49 domain domain NN cord-299038-e0nsol3y 169 50 ( ( -LRB- cord-299038-e0nsol3y 169 51 Delputte Delputte NNP cord-299038-e0nsol3y 169 52 and and CC cord-299038-e0nsol3y 169 53 Nauwynck Nauwynck NNP cord-299038-e0nsol3y 169 54 2004 2004 CD cord-299038-e0nsol3y 170 1 ; ; : cord-299038-e0nsol3y 170 2 Delputte Delputte NNP cord-299038-e0nsol3y 170 3 et et NNP cord-299038-e0nsol3y 170 4 al al NNP cord-299038-e0nsol3y 170 5 . . NNP cord-299038-e0nsol3y 170 6 2007 2007 CD cord-299038-e0nsol3y 170 7 ) ) -RRB- cord-299038-e0nsol3y 170 8 . . . cord-299038-e0nsol3y 171 1 Siglec-1 siglec-1 JJ cord-299038-e0nsol3y 171 2 neutralization neutralization NN cord-299038-e0nsol3y 171 3 blocks block VBZ cord-299038-e0nsol3y 171 4 PRRSV PRRSV NNP cord-299038-e0nsol3y 171 5 infection infection NN cord-299038-e0nsol3y 171 6 in in IN cord-299038-e0nsol3y 171 7 a a DT cord-299038-e0nsol3y 171 8 dose dose NN cord-299038-e0nsol3y 171 9 - - HYPH cord-299038-e0nsol3y 171 10 dependent dependent JJ cord-299038-e0nsol3y 171 11 manner manner NN cord-299038-e0nsol3y 171 12 , , , cord-299038-e0nsol3y 171 13 and and CC cord-299038-e0nsol3y 171 14 overexpression overexpression NN cord-299038-e0nsol3y 171 15 of of IN cord-299038-e0nsol3y 171 16 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 171 17 in in IN cord-299038-e0nsol3y 171 18 non non JJ cord-299038-e0nsol3y 171 19 - - JJ cord-299038-e0nsol3y 171 20 permissive permissive JJ cord-299038-e0nsol3y 171 21 cells cell NNS cord-299038-e0nsol3y 171 22 enhances enhance VBZ cord-299038-e0nsol3y 171 23 PRRSV PRRSV NNP cord-299038-e0nsol3y 171 24 cell cell NN cord-299038-e0nsol3y 171 25 attachment attachment NN cord-299038-e0nsol3y 171 26 and and CC cord-299038-e0nsol3y 171 27 internalization internalization NN cord-299038-e0nsol3y 172 1 ( ( -LRB- cord-299038-e0nsol3y 172 2 Duan Duan NNP cord-299038-e0nsol3y 172 3 et et FW cord-299038-e0nsol3y 172 4 al al NNP cord-299038-e0nsol3y 172 5 . . . cord-299038-e0nsol3y 173 1 1998 1998 CD cord-299038-e0nsol3y 173 2 ; ; : cord-299038-e0nsol3y 173 3 Vanderheijden Vanderheijden NNP cord-299038-e0nsol3y 173 4 et et NNP cord-299038-e0nsol3y 173 5 al al NNP cord-299038-e0nsol3y 173 6 . . NNP cord-299038-e0nsol3y 173 7 2003 2003 CD cord-299038-e0nsol3y 173 8 ) ) -RRB- cord-299038-e0nsol3y 173 9 . . . cord-299038-e0nsol3y 174 1 In in IN cord-299038-e0nsol3y 174 2 subsequent subsequent JJ cord-299038-e0nsol3y 174 3 studies study NNS cord-299038-e0nsol3y 174 4 , , , cord-299038-e0nsol3y 174 5 Sias Sias NNP cord-299038-e0nsol3y 174 6 on on IN cord-299038-e0nsol3y 174 7 the the DT cord-299038-e0nsol3y 174 8 viral viral JJ cord-299038-e0nsol3y 174 9 envelope envelope NN cord-299038-e0nsol3y 174 10 structural structural JJ cord-299038-e0nsol3y 174 11 protein protein NN cord-299038-e0nsol3y 174 12 M M NNP cord-299038-e0nsol3y 174 13 / / SYM cord-299038-e0nsol3y 174 14 GP5 GP5 NNP cord-299038-e0nsol3y 174 15 heterodimer heterodimer NN cord-299038-e0nsol3y 174 16 were be VBD cord-299038-e0nsol3y 174 17 identified identify VBN cord-299038-e0nsol3y 174 18 as as IN cord-299038-e0nsol3y 174 19 the the DT cord-299038-e0nsol3y 174 20 binding bind VBG cord-299038-e0nsol3y 174 21 target target NN cord-299038-e0nsol3y 174 22 of of IN cord-299038-e0nsol3y 174 23 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 174 24 ( ( -LRB- cord-299038-e0nsol3y 174 25 Van Van NNP cord-299038-e0nsol3y 174 26 Breedam Breedam NNP cord-299038-e0nsol3y 174 27 et et NNP cord-299038-e0nsol3y 174 28 al al NNP cord-299038-e0nsol3y 174 29 . . NNP cord-299038-e0nsol3y 174 30 2010 2010 CD cord-299038-e0nsol3y 174 31 ) ) -RRB- cord-299038-e0nsol3y 174 32 , , , cord-299038-e0nsol3y 174 33 and and CC cord-299038-e0nsol3y 174 34 the the DT cord-299038-e0nsol3y 174 35 interaction interaction NN cord-299038-e0nsol3y 174 36 of of IN cord-299038-e0nsol3y 174 37 PRRSV PRRSV NNP cord-299038-e0nsol3y 174 38 with with IN cord-299038-e0nsol3y 174 39 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 174 40 interferes interfere VBZ cord-299038-e0nsol3y 174 41 with with IN cord-299038-e0nsol3y 174 42 macrophage macrophage NN cord-299038-e0nsol3y 174 43 phagocytic phagocytic JJ cord-299038-e0nsol3y 174 44 activity activity NN cord-299038-e0nsol3y 174 45 , , , cord-299038-e0nsol3y 174 46 which which WDT cord-299038-e0nsol3y 174 47 may may MD cord-299038-e0nsol3y 174 48 increase increase VB cord-299038-e0nsol3y 174 49 the the DT cord-299038-e0nsol3y 174 50 incidence incidence NN cord-299038-e0nsol3y 174 51 and and CC cord-299038-e0nsol3y 174 52 severity severity NN cord-299038-e0nsol3y 174 53 of of IN cord-299038-e0nsol3y 174 54 secondary secondary JJ cord-299038-e0nsol3y 174 55 bacterial bacterial JJ cord-299038-e0nsol3y 174 56 infections infection NNS cord-299038-e0nsol3y 174 57 complicating complicate VBG cord-299038-e0nsol3y 174 58 primary primary JJ cord-299038-e0nsol3y 174 59 PRRSV PRRSV NNP cord-299038-e0nsol3y 174 60 disease disease NN cord-299038-e0nsol3y 174 61 ( ( -LRB- cord-299038-e0nsol3y 174 62 De De NNP cord-299038-e0nsol3y 174 63 Baere Baere NNP cord-299038-e0nsol3y 174 64 et et FW cord-299038-e0nsol3y 174 65 al al NNP cord-299038-e0nsol3y 174 66 . . NNP cord-299038-e0nsol3y 174 67 2012 2012 CD cord-299038-e0nsol3y 174 68 ) ) -RRB- cord-299038-e0nsol3y 174 69 . . . cord-299038-e0nsol3y 175 1 Since since IN cord-299038-e0nsol3y 175 2 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 175 3 and and CC cord-299038-e0nsol3y 175 4 CD163 CD163 NNP cord-299038-e0nsol3y 175 5 are be VBP cord-299038-e0nsol3y 175 6 the the DT cord-299038-e0nsol3y 175 7 two two CD cord-299038-e0nsol3y 175 8 key key JJ cord-299038-e0nsol3y 175 9 receptors receptor NNS cord-299038-e0nsol3y 175 10 for for IN cord-299038-e0nsol3y 175 11 PRRSV PRRSV NNP cord-299038-e0nsol3y 175 12 entry entry NN cord-299038-e0nsol3y 175 13 and and CC cord-299038-e0nsol3y 175 14 internalization internalization NN cord-299038-e0nsol3y 175 15 into into IN cord-299038-e0nsol3y 175 16 porcine porcine JJ cord-299038-e0nsol3y 175 17 alveolar alveolar NN cord-299038-e0nsol3y 175 18 macrophages macrophage NNS cord-299038-e0nsol3y 175 19 , , , cord-299038-e0nsol3y 175 20 neutralization neutralization NN cord-299038-e0nsol3y 175 21 of of IN cord-299038-e0nsol3y 175 22 these these DT cord-299038-e0nsol3y 175 23 two two CD cord-299038-e0nsol3y 175 24 viral viral JJ cord-299038-e0nsol3y 175 25 receptors receptor NNS cord-299038-e0nsol3y 175 26 has have VBZ cord-299038-e0nsol3y 175 27 been be VBN cord-299038-e0nsol3y 175 28 explored explore VBN cord-299038-e0nsol3y 175 29 as as IN cord-299038-e0nsol3y 175 30 a a DT cord-299038-e0nsol3y 175 31 potential potential JJ cord-299038-e0nsol3y 175 32 target target NN cord-299038-e0nsol3y 175 33 to to TO cord-299038-e0nsol3y 175 34 control control VB cord-299038-e0nsol3y 175 35 PRRSV PRRSV NNP cord-299038-e0nsol3y 175 36 infection infection NN cord-299038-e0nsol3y 175 37 in in IN cord-299038-e0nsol3y 175 38 pigs pig NNS cord-299038-e0nsol3y 175 39 . . . cord-299038-e0nsol3y 176 1 Two two CD cord-299038-e0nsol3y 176 2 recent recent JJ cord-299038-e0nsol3y 176 3 reports report NNS cord-299038-e0nsol3y 176 4 support support VBP cord-299038-e0nsol3y 176 5 this this DT cord-299038-e0nsol3y 176 6 therapeutic therapeutic JJ cord-299038-e0nsol3y 176 7 concept concept NN cord-299038-e0nsol3y 176 8 . . . cord-299038-e0nsol3y 177 1 Neutralization neutralization NN cord-299038-e0nsol3y 177 2 of of IN cord-299038-e0nsol3y 177 3 PRRSV PRRSV NNP cord-299038-e0nsol3y 177 4 infectivity infectivity NN cord-299038-e0nsol3y 177 5 for for IN cord-299038-e0nsol3y 177 6 porcine porcine JJ cord-299038-e0nsol3y 177 7 alveolar alveolar NN cord-299038-e0nsol3y 177 8 macrophages macrophage NNS cord-299038-e0nsol3y 177 9 was be VBD cord-299038-e0nsol3y 177 10 achieved achieve VBN cord-299038-e0nsol3y 177 11 by by IN cord-299038-e0nsol3y 177 12 addition addition NN cord-299038-e0nsol3y 177 13 of of IN cord-299038-e0nsol3y 177 14 soluble soluble JJ cord-299038-e0nsol3y 177 15 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 177 16 and and CC cord-299038-e0nsol3y 177 17 CD163 CD163 NNP cord-299038-e0nsol3y 177 18 Fc Fc NNP cord-299038-e0nsol3y 177 19 fusion fusion NN cord-299038-e0nsol3y 177 20 proteins protein NNS cord-299038-e0nsol3y 177 21 , , , cord-299038-e0nsol3y 177 22 or or CC cord-299038-e0nsol3y 177 23 by by IN cord-299038-e0nsol3y 177 24 recombinant recombinant JJ cord-299038-e0nsol3y 177 25 adenovirus adenovirus NN cord-299038-e0nsol3y 177 26 - - : cord-299038-e0nsol3y 177 27 or or CC cord-299038-e0nsol3y 177 28 exosome exosome RB cord-299038-e0nsol3y 177 29 - - HYPH cord-299038-e0nsol3y 177 30 delivered deliver VBN cord-299038-e0nsol3y 177 31 microRNA microRNA NNP cord-299038-e0nsol3y 177 32 that that WDT cord-299038-e0nsol3y 177 33 specifically specifically RB cord-299038-e0nsol3y 177 34 targeted target VBD cord-299038-e0nsol3y 177 35 CD163 CD163 NNP cord-299038-e0nsol3y 177 36 and and CC cord-299038-e0nsol3y 177 37 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 178 1 ( ( -LRB- cord-299038-e0nsol3y 178 2 Chen Chen NNP cord-299038-e0nsol3y 178 3 et et NNP cord-299038-e0nsol3y 178 4 al al NNP cord-299038-e0nsol3y 178 5 . . . cord-299038-e0nsol3y 179 1 2014b 2014b . cord-299038-e0nsol3y 180 1 ; ; : cord-299038-e0nsol3y 180 2 Zhu Zhu NNP cord-299038-e0nsol3y 180 3 et et FW cord-299038-e0nsol3y 180 4 al al NNP cord-299038-e0nsol3y 180 5 . . NNP cord-299038-e0nsol3y 180 6 2014 2014 CD cord-299038-e0nsol3y 180 7 ) ) -RRB- cord-299038-e0nsol3y 180 8 . . . cord-299038-e0nsol3y 181 1 In in IN cord-299038-e0nsol3y 181 2 addition addition NN cord-299038-e0nsol3y 181 3 , , , cord-299038-e0nsol3y 181 4 pigs pig NNS cord-299038-e0nsol3y 181 5 that that WDT cord-299038-e0nsol3y 181 6 received receive VBD cord-299038-e0nsol3y 181 7 recombinant recombinant JJ cord-299038-e0nsol3y 181 8 adenovirus adenovirus NN cord-299038-e0nsol3y 181 9 - - HYPH cord-299038-e0nsol3y 181 10 delivered deliver VBN cord-299038-e0nsol3y 181 11 soluble soluble JJ cord-299038-e0nsol3y 181 12 CD163 CD163 NNP cord-299038-e0nsol3y 181 13 plus plus CC cord-299038-e0nsol3y 181 14 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 181 15 had have VBD cord-299038-e0nsol3y 181 16 reduced reduce VBN cord-299038-e0nsol3y 181 17 PPRSV PPRSV NNS cord-299038-e0nsol3y 181 18 viral viral JJ cord-299038-e0nsol3y 181 19 loads load NNS cord-299038-e0nsol3y 181 20 and and CC cord-299038-e0nsol3y 181 21 fecal fecal JJ cord-299038-e0nsol3y 181 22 viral viral JJ cord-299038-e0nsol3y 181 23 emission emission NN cord-299038-e0nsol3y 181 24 , , , cord-299038-e0nsol3y 181 25 concurrent concurrent JJ cord-299038-e0nsol3y 181 26 with with IN cord-299038-e0nsol3y 181 27 improved improved JJ cord-299038-e0nsol3y 181 28 clinical clinical JJ cord-299038-e0nsol3y 181 29 scores score NNS cord-299038-e0nsol3y 181 30 and and CC cord-299038-e0nsol3y 181 31 higher high JJR cord-299038-e0nsol3y 181 32 survival survival NN cord-299038-e0nsol3y 181 33 rates rate NNS cord-299038-e0nsol3y 181 34 from from IN cord-299038-e0nsol3y 181 35 the the DT cord-299038-e0nsol3y 181 36 contagious contagious JJ cord-299038-e0nsol3y 181 37 infection infection NN cord-299038-e0nsol3y 181 38 ( ( -LRB- cord-299038-e0nsol3y 181 39 Xia Xia NNP cord-299038-e0nsol3y 181 40 et et NNP cord-299038-e0nsol3y 181 41 al al NNP cord-299038-e0nsol3y 181 42 . . . cord-299038-e0nsol3y 181 43 2018 2018 CD cord-299038-e0nsol3y 181 44 ) ) -RRB- cord-299038-e0nsol3y 181 45 . . . cord-299038-e0nsol3y 182 1 It -PRON- PRP cord-299038-e0nsol3y 182 2 is be VBZ cord-299038-e0nsol3y 182 3 notable notable JJ cord-299038-e0nsol3y 182 4 that that IN cord-299038-e0nsol3y 182 5 an an DT cord-299038-e0nsol3y 182 6 in in IN cord-299038-e0nsol3y 182 7 vivo vivo NN cord-299038-e0nsol3y 182 8 study study NN cord-299038-e0nsol3y 182 9 conducted conduct VBN cord-299038-e0nsol3y 182 10 in in IN cord-299038-e0nsol3y 182 11 SIGLEC1 siglec1 NN cord-299038-e0nsol3y 182 12 knockout knockout NN cord-299038-e0nsol3y 182 13 pigs pig NNS cord-299038-e0nsol3y 182 14 found find VBD cord-299038-e0nsol3y 182 15 that that IN cord-299038-e0nsol3y 182 16 the the DT cord-299038-e0nsol3y 182 17 absence absence NN cord-299038-e0nsol3y 182 18 of of IN cord-299038-e0nsol3y 182 19 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 182 20 expression expression NN cord-299038-e0nsol3y 182 21 does do VBZ cord-299038-e0nsol3y 182 22 not not RB cord-299038-e0nsol3y 182 23 alter alter VB cord-299038-e0nsol3y 182 24 to to IN cord-299038-e0nsol3y 182 25 the the DT cord-299038-e0nsol3y 182 26 clinical clinical JJ cord-299038-e0nsol3y 182 27 course course NN cord-299038-e0nsol3y 182 28 and and CC cord-299038-e0nsol3y 182 29 histopathology histopathology NN cord-299038-e0nsol3y 182 30 of of IN cord-299038-e0nsol3y 182 31 PRRSV PRRSV NNP cord-299038-e0nsol3y 182 32 infection infection NN cord-299038-e0nsol3y 182 33 ( ( -LRB- cord-299038-e0nsol3y 182 34 Prather Prather NNP cord-299038-e0nsol3y 182 35 et et NNP cord-299038-e0nsol3y 182 36 al al NNP cord-299038-e0nsol3y 182 37 . . NNP cord-299038-e0nsol3y 182 38 2013 2013 CD cord-299038-e0nsol3y 182 39 ) ) -RRB- cord-299038-e0nsol3y 182 40 , , , cord-299038-e0nsol3y 182 41 implying imply VBG cord-299038-e0nsol3y 182 42 a a DT cord-299038-e0nsol3y 182 43 potential potential JJ cord-299038-e0nsol3y 182 44 redundant redundant JJ cord-299038-e0nsol3y 182 45 function function NN cord-299038-e0nsol3y 182 46 of of IN cord-299038-e0nsol3y 182 47 CD163 CD163 NNP cord-299038-e0nsol3y 182 48 and and CC cord-299038-e0nsol3y 182 49 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 182 50 in in IN cord-299038-e0nsol3y 182 51 PRRSV PRRSV NNP cord-299038-e0nsol3y 182 52 infection infection NN cord-299038-e0nsol3y 182 53 and and CC cord-299038-e0nsol3y 182 54 the the DT cord-299038-e0nsol3y 182 55 importance importance NN cord-299038-e0nsol3y 182 56 of of IN cord-299038-e0nsol3y 182 57 dual dual JJ cord-299038-e0nsol3y 182 58 targeting targeting NN cord-299038-e0nsol3y 182 59 for for IN cord-299038-e0nsol3y 182 60 potential potential JJ cord-299038-e0nsol3y 182 61 pharmacological pharmacological JJ cord-299038-e0nsol3y 182 62 interventions intervention NNS cord-299038-e0nsol3y 182 63 . . . cord-299038-e0nsol3y 183 1 Although although IN cord-299038-e0nsol3y 183 2 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 183 3 and and CC cord-299038-e0nsol3y 183 4 CD163 CD163 NNP cord-299038-e0nsol3y 183 5 are be VBP cord-299038-e0nsol3y 183 6 general general RB cord-299038-e0nsol3y 183 7 recognized recognize VBN cord-299038-e0nsol3y 183 8 as as IN cord-299038-e0nsol3y 183 9 the the DT cord-299038-e0nsol3y 183 10 key key JJ cord-299038-e0nsol3y 183 11 entry entry NN cord-299038-e0nsol3y 183 12 mediators mediator NNS cord-299038-e0nsol3y 183 13 for for IN cord-299038-e0nsol3y 183 14 PRRSV PRRSV NNP cord-299038-e0nsol3y 183 15 infection infection NN cord-299038-e0nsol3y 183 16 , , , cord-299038-e0nsol3y 183 17 a a DT cord-299038-e0nsol3y 183 18 recent recent JJ cord-299038-e0nsol3y 183 19 report report NN cord-299038-e0nsol3y 183 20 demonstrated demonstrate VBD cord-299038-e0nsol3y 183 21 that that IN cord-299038-e0nsol3y 183 22 certain certain JJ cord-299038-e0nsol3y 183 23 PRRSV PRRSV NNP cord-299038-e0nsol3y 183 24 strains strain NNS cord-299038-e0nsol3y 183 25 can can MD cord-299038-e0nsol3y 183 26 infect infect VB cord-299038-e0nsol3y 183 27 Siglec-1-deficient siglec-1-deficient NN cord-299038-e0nsol3y 183 28 cells cell NNS cord-299038-e0nsol3y 183 29 by by IN cord-299038-e0nsol3y 183 30 exploiting exploit VBG cord-299038-e0nsol3y 183 31 Siglec-10 Siglec-10 NNS cord-299038-e0nsol3y 183 32 in in IN cord-299038-e0nsol3y 183 33 the the DT cord-299038-e0nsol3y 183 34 presence presence NN cord-299038-e0nsol3y 183 35 of of IN cord-299038-e0nsol3y 183 36 CD163 CD163 NNP cord-299038-e0nsol3y 183 37 ( ( -LRB- cord-299038-e0nsol3y 183 38 Frydas Frydas NNP cord-299038-e0nsol3y 183 39 and and CC cord-299038-e0nsol3y 183 40 Nauwynck Nauwynck NNP cord-299038-e0nsol3y 183 41 2016 2016 CD cord-299038-e0nsol3y 183 42 ; ; : cord-299038-e0nsol3y 183 43 Xie Xie NNP cord-299038-e0nsol3y 183 44 et et FW cord-299038-e0nsol3y 183 45 al al NNP cord-299038-e0nsol3y 183 46 . . . cord-299038-e0nsol3y 183 47 2017 2017 CD cord-299038-e0nsol3y 183 48 ) ) -RRB- cord-299038-e0nsol3y 183 49 . . . cord-299038-e0nsol3y 184 1 Siglec-10 Siglec-10 NNP cord-299038-e0nsol3y 184 2 showed show VBD cord-299038-e0nsol3y 184 3 a a DT cord-299038-e0nsol3y 184 4 higher high JJR cord-299038-e0nsol3y 184 5 affinity affinity NN cord-299038-e0nsol3y 184 6 to to TO cord-299038-e0nsol3y 184 7 type type VB cord-299038-e0nsol3y 184 8 2 2 CD cord-299038-e0nsol3y 184 9 PRRSV prrsv NN cord-299038-e0nsol3y 184 10 vs. vs. IN cord-299038-e0nsol3y 184 11 type type NN cord-299038-e0nsol3y 184 12 1 1 CD cord-299038-e0nsol3y 184 13 PRRSV PRRSV NNP cord-299038-e0nsol3y 184 14 and and CC cord-299038-e0nsol3y 184 15 mediates mediate VBZ cord-299038-e0nsol3y 184 16 attachment attachment NN cord-299038-e0nsol3y 184 17 and and CC cord-299038-e0nsol3y 184 18 endocytosis endocytosis NN cord-299038-e0nsol3y 184 19 of of IN cord-299038-e0nsol3y 184 20 PRRSV PRRSV NNP cord-299038-e0nsol3y 184 21 in in IN cord-299038-e0nsol3y 184 22 a a DT cord-299038-e0nsol3y 184 23 Sia sia JJ cord-299038-e0nsol3y 184 24 - - HYPH cord-299038-e0nsol3y 184 25 dependent dependent JJ cord-299038-e0nsol3y 184 26 manner manner NN cord-299038-e0nsol3y 184 27 , , , cord-299038-e0nsol3y 184 28 while while IN cord-299038-e0nsol3y 184 29 transfection transfection NN cord-299038-e0nsol3y 184 30 of of IN cord-299038-e0nsol3y 184 31 Siglec-10 Siglec-10 NNS cord-299038-e0nsol3y 184 32 into into IN cord-299038-e0nsol3y 184 33 non non JJ cord-299038-e0nsol3y 184 34 - - JJ cord-299038-e0nsol3y 184 35 permissive permissive JJ cord-299038-e0nsol3y 184 36 cells cell NNS cord-299038-e0nsol3y 184 37 also also RB cord-299038-e0nsol3y 184 38 restored restore VBD cord-299038-e0nsol3y 184 39 the the DT cord-299038-e0nsol3y 184 40 PRRSV PRRSV NNP cord-299038-e0nsol3y 184 41 infectivity infectivity NN cord-299038-e0nsol3y 184 42 . . . cord-299038-e0nsol3y 185 1 These these DT cord-299038-e0nsol3y 185 2 findings finding NNS cord-299038-e0nsol3y 185 3 indicate indicate VBP cord-299038-e0nsol3y 185 4 that that IN cord-299038-e0nsol3y 185 5 PRRSV PRRSV NNP cord-299038-e0nsol3y 185 6 can can MD cord-299038-e0nsol3y 185 7 use use VB cord-299038-e0nsol3y 185 8 several several JJ cord-299038-e0nsol3y 185 9 Siglecs Siglecs NNP cord-299038-e0nsol3y 185 10 to to TO cord-299038-e0nsol3y 185 11 enter enter VB cord-299038-e0nsol3y 185 12 macrophages macrophage NNS cord-299038-e0nsol3y 185 13 and and CC cord-299038-e0nsol3y 185 14 may may MD cord-299038-e0nsol3y 185 15 influence influence VB cord-299038-e0nsol3y 185 16 strain strain NN cord-299038-e0nsol3y 185 17 differences difference NNS cord-299038-e0nsol3y 185 18 in in IN cord-299038-e0nsol3y 185 19 pathogenesis pathogenesis NN cord-299038-e0nsol3y 185 20 ( ( -LRB- cord-299038-e0nsol3y 185 21 Xie Xie NNP cord-299038-e0nsol3y 185 22 et et FW cord-299038-e0nsol3y 185 23 al al NNP cord-299038-e0nsol3y 185 24 . . . cord-299038-e0nsol3y 185 25 2017 2017 CD cord-299038-e0nsol3y 185 26 ) ) -RRB- cord-299038-e0nsol3y 185 27 . . . cord-299038-e0nsol3y 186 1 Of of IN cord-299038-e0nsol3y 186 2 note note NN cord-299038-e0nsol3y 186 3 , , , cord-299038-e0nsol3y 186 4 PRRSV PRRSV NNP cord-299038-e0nsol3y 186 5 lung lung NN cord-299038-e0nsol3y 186 6 infection infection NN cord-299038-e0nsol3y 186 7 induces induce VBZ cord-299038-e0nsol3y 186 8 minimal minimal JJ cord-299038-e0nsol3y 186 9 production production NN cord-299038-e0nsol3y 186 10 of of IN cord-299038-e0nsol3y 186 11 type type NN cord-299038-e0nsol3y 187 1 I -PRON- PRP cord-299038-e0nsol3y 187 2 interferon interferon VBD cord-299038-e0nsol3y 187 3 and and CC cord-299038-e0nsol3y 187 4 inflammatory inflammatory JJ cord-299038-e0nsol3y 187 5 cytokines cytokine NNS cord-299038-e0nsol3y 187 6 compared compare VBN cord-299038-e0nsol3y 187 7 to to IN cord-299038-e0nsol3y 187 8 infections infection NNS cord-299038-e0nsol3y 187 9 caused cause VBN cord-299038-e0nsol3y 187 10 by by IN cord-299038-e0nsol3y 187 11 swine swine NN cord-299038-e0nsol3y 187 12 influenza influenza NN cord-299038-e0nsol3y 187 13 virus virus NN cord-299038-e0nsol3y 187 14 and and CC cord-299038-e0nsol3y 187 15 porcine porcine JJ cord-299038-e0nsol3y 187 16 respiratory respiratory JJ cord-299038-e0nsol3y 187 17 coronavirus coronavirus NN cord-299038-e0nsol3y 188 1 ( ( -LRB- cord-299038-e0nsol3y 188 2 Van Van NNP cord-299038-e0nsol3y 188 3 Reeth Reeth NNP cord-299038-e0nsol3y 188 4 et et NNP cord-299038-e0nsol3y 188 5 al al NNP cord-299038-e0nsol3y 188 6 . . . cord-299038-e0nsol3y 188 7 1999 1999 CD cord-299038-e0nsol3y 188 8 ) ) -RRB- cord-299038-e0nsol3y 188 9 . . . cord-299038-e0nsol3y 189 1 Like like IN cord-299038-e0nsol3y 189 2 other other JJ cord-299038-e0nsol3y 189 3 inhibitory inhibitory JJ cord-299038-e0nsol3y 189 4 Siglecs Siglecs NNP cord-299038-e0nsol3y 189 5 , , , cord-299038-e0nsol3y 189 6 porcine porcine JJ cord-299038-e0nsol3y 189 7 Siglec-10 Siglec-10 NNS cord-299038-e0nsol3y 189 8 contains contain VBZ cord-299038-e0nsol3y 189 9 one one CD cord-299038-e0nsol3y 189 10 ITIM ITIM NNP cord-299038-e0nsol3y 189 11 and and CC cord-299038-e0nsol3y 189 12 one one CD cord-299038-e0nsol3y 189 13 ITIMlike itimlike JJ cord-299038-e0nsol3y 189 14 motif motif NN cord-299038-e0nsol3y 189 15 possibly possibly RB cord-299038-e0nsol3y 189 16 , , , cord-299038-e0nsol3y 189 17 likely likely RB cord-299038-e0nsol3y 189 18 counteracting counteract VBG cord-299038-e0nsol3y 189 19 key key JJ cord-299038-e0nsol3y 189 20 immune immune JJ cord-299038-e0nsol3y 189 21 activation activation NN cord-299038-e0nsol3y 189 22 pathways pathway NNS cord-299038-e0nsol3y 189 23 induced induce VBN cord-299038-e0nsol3y 189 24 by by IN cord-299038-e0nsol3y 189 25 viral viral JJ cord-299038-e0nsol3y 189 26 infection infection NN cord-299038-e0nsol3y 189 27 . . . cord-299038-e0nsol3y 190 1 Budding bud VBG cord-299038-e0nsol3y 190 2 from from IN cord-299038-e0nsol3y 190 3 the the DT cord-299038-e0nsol3y 190 4 GSL GSL NNP cord-299038-e0nsol3y 190 5 - - HYPH cord-299038-e0nsol3y 190 6 enriched enrich VBN cord-299038-e0nsol3y 190 7 domain domain NN cord-299038-e0nsol3y 190 8 is be VBZ cord-299038-e0nsol3y 190 9 a a DT cord-299038-e0nsol3y 190 10 conserved conserved JJ cord-299038-e0nsol3y 190 11 feature feature NN cord-299038-e0nsol3y 190 12 of of IN cord-299038-e0nsol3y 190 13 other other JJ cord-299038-e0nsol3y 190 14 enveloped envelop VBN cord-299038-e0nsol3y 190 15 viruses virus NNS cord-299038-e0nsol3y 190 16 . . . cord-299038-e0nsol3y 191 1 Incorporation Incorporation NNP cord-299038-e0nsol3y 191 2 of of IN cord-299038-e0nsol3y 191 3 host host NN cord-299038-e0nsol3y 191 4 GSL GSL NNP cord-299038-e0nsol3y 191 5 into into IN cord-299038-e0nsol3y 191 6 the the DT cord-299038-e0nsol3y 191 7 viral viral JJ cord-299038-e0nsol3y 191 8 envelope envelope NN cord-299038-e0nsol3y 191 9 is be VBZ cord-299038-e0nsol3y 191 10 found find VBN cord-299038-e0nsol3y 191 11 in in IN cord-299038-e0nsol3y 191 12 Hendra Hendra NNP cord-299038-e0nsol3y 191 13 and and CC cord-299038-e0nsol3y 191 14 Nipah Nipah NNP cord-299038-e0nsol3y 191 15 viruses virus NNS cord-299038-e0nsol3y 191 16 , , , cord-299038-e0nsol3y 191 17 two two CD cord-299038-e0nsol3y 191 18 enveloped envelop VBN cord-299038-e0nsol3y 191 19 RNA RNA NNP cord-299038-e0nsol3y 191 20 viruses virus NNS cord-299038-e0nsol3y 191 21 of of IN cord-299038-e0nsol3y 191 22 the the DT cord-299038-e0nsol3y 191 23 family family NN cord-299038-e0nsol3y 191 24 Paramyxoviridae Paramyxoviridae NNP cord-299038-e0nsol3y 191 25 , , , cord-299038-e0nsol3y 191 26 and and CC cord-299038-e0nsol3y 191 27 these these DT cord-299038-e0nsol3y 191 28 viruses virus NNS cord-299038-e0nsol3y 191 29 can can MD cord-299038-e0nsol3y 191 30 utilize utilize VB cord-299038-e0nsol3y 191 31 the the DT cord-299038-e0nsol3y 191 32 Sia Sia NNP cord-299038-e0nsol3y 191 33 - - HYPH cord-299038-e0nsol3y 191 34 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 191 35 axis axis NN cord-299038-e0nsol3y 191 36 to to TO cord-299038-e0nsol3y 191 37 potentiate potentiate VB cord-299038-e0nsol3y 191 38 mDC mdc NN cord-299038-e0nsol3y 191 39 - - HYPH cord-299038-e0nsol3y 191 40 dependent dependent JJ cord-299038-e0nsol3y 191 41 capture capture NN cord-299038-e0nsol3y 191 42 and and CC cord-299038-e0nsol3y 191 43 trans trans NN cord-299038-e0nsol3y 191 44 - - NN cord-299038-e0nsol3y 191 45 infection infection NN cord-299038-e0nsol3y 191 46 of of IN cord-299038-e0nsol3y 191 47 T t NN cord-299038-e0nsol3y 191 48 cells cell NNS cord-299038-e0nsol3y 191 49 . . . cord-299038-e0nsol3y 192 1 Ebola Ebola NNP cord-299038-e0nsol3y 192 2 viruses virus NNS cord-299038-e0nsol3y 192 3 cause cause VBP cord-299038-e0nsol3y 192 4 lethal lethal JJ cord-299038-e0nsol3y 192 5 hemorrhagic hemorrhagic JJ cord-299038-e0nsol3y 192 6 fever fever NN cord-299038-e0nsol3y 192 7 in in IN cord-299038-e0nsol3y 192 8 humans human NNS cord-299038-e0nsol3y 192 9 , , , cord-299038-e0nsol3y 192 10 with with IN cord-299038-e0nsol3y 192 11 many many JJ cord-299038-e0nsol3y 192 12 recent recent JJ cord-299038-e0nsol3y 192 13 outbreaks outbreak NNS cord-299038-e0nsol3y 192 14 on on IN cord-299038-e0nsol3y 192 15 the the DT cord-299038-e0nsol3y 192 16 African african JJ cord-299038-e0nsol3y 192 17 continent continent NN cord-299038-e0nsol3y 192 18 . . . cord-299038-e0nsol3y 193 1 Recently recently RB cord-299038-e0nsol3y 193 2 , , , cord-299038-e0nsol3y 193 3 Ebola Ebola NNP cord-299038-e0nsol3y 193 4 virus virus NN cord-299038-e0nsol3y 193 5 entry entry NN cord-299038-e0nsol3y 193 6 into into IN cord-299038-e0nsol3y 193 7 activated activate VBN cord-299038-e0nsol3y 193 8 DCs DCs NNP cord-299038-e0nsol3y 193 9 was be VBD cord-299038-e0nsol3y 193 10 shown show VBN cord-299038-e0nsol3y 193 11 to to TO cord-299038-e0nsol3y 193 12 involve involve VB cord-299038-e0nsol3y 193 13 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 193 14 recognition recognition NN cord-299038-e0nsol3y 193 15 of of IN cord-299038-e0nsol3y 193 16 sialylated sialylated JJ cord-299038-e0nsol3y 193 17 gangliosides ganglioside NNS cord-299038-e0nsol3y 193 18 anchored anchor VBD cord-299038-e0nsol3y 193 19 to to IN cord-299038-e0nsol3y 193 20 Ebola Ebola NNP cord-299038-e0nsol3y 193 21 virus virus NN cord-299038-e0nsol3y 193 22 membranes membrane NNS cord-299038-e0nsol3y 193 23 ( ( -LRB- cord-299038-e0nsol3y 193 24 Perez Perez NNP cord-299038-e0nsol3y 193 25 - - HYPH cord-299038-e0nsol3y 193 26 Zsolt Zsolt NNP cord-299038-e0nsol3y 193 27 et et NNP cord-299038-e0nsol3y 193 28 al al NNP cord-299038-e0nsol3y 193 29 . . NNP cord-299038-e0nsol3y 193 30 2019b 2019b CD cord-299038-e0nsol3y 193 31 ) ) -RRB- cord-299038-e0nsol3y 193 32 . . . cord-299038-e0nsol3y 194 1 Blockade Blockade NNP cord-299038-e0nsol3y 194 2 of of IN cord-299038-e0nsol3y 194 3 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 194 4 by by IN cord-299038-e0nsol3y 194 5 specific specific JJ cord-299038-e0nsol3y 194 6 monoclonal monoclonal JJ cord-299038-e0nsol3y 194 7 antibodies antibody NNS cord-299038-e0nsol3y 194 8 interrupted interrupt VBD cord-299038-e0nsol3y 194 9 Ebola Ebola NNP cord-299038-e0nsol3y 194 10 viral viral JJ cord-299038-e0nsol3y 194 11 uptake uptake NN cord-299038-e0nsol3y 194 12 and and CC cord-299038-e0nsol3y 194 13 cytoplasmic cytoplasmic JJ cord-299038-e0nsol3y 194 14 entry entry NN cord-299038-e0nsol3y 194 15 , , , cord-299038-e0nsol3y 194 16 providing provide VBG cord-299038-e0nsol3y 194 17 cross cross NN cord-299038-e0nsol3y 194 18 - - NN cord-299038-e0nsol3y 194 19 protection protection NN cord-299038-e0nsol3y 194 20 against against IN cord-299038-e0nsol3y 194 21 other other JJ cord-299038-e0nsol3y 194 22 GSL GSL NNP cord-299038-e0nsol3y 194 23 - - HYPH cord-299038-e0nsol3y 194 24 containing contain VBG cord-299038-e0nsol3y 194 25 viruses virus NNS cord-299038-e0nsol3y 194 26 including include VBG cord-299038-e0nsol3y 194 27 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 195 1 ( ( -LRB- cord-299038-e0nsol3y 195 2 Perez Perez NNP cord-299038-e0nsol3y 195 3 - - HYPH cord-299038-e0nsol3y 195 4 Zsolt Zsolt NNP cord-299038-e0nsol3y 195 5 et et NNP cord-299038-e0nsol3y 195 6 al al NNP cord-299038-e0nsol3y 195 7 . . NNP cord-299038-e0nsol3y 195 8 2019b 2019b CD cord-299038-e0nsol3y 195 9 ) ) -RRB- cord-299038-e0nsol3y 195 10 . . . cord-299038-e0nsol3y 196 1 This this DT cord-299038-e0nsol3y 196 2 finding finding NN cord-299038-e0nsol3y 196 3 suggests suggest VBZ cord-299038-e0nsol3y 196 4 that that IN cord-299038-e0nsol3y 196 5 incorporation incorporation NN cord-299038-e0nsol3y 196 6 of of IN cord-299038-e0nsol3y 196 7 GSLs gsl NNS cord-299038-e0nsol3y 196 8 in in IN cord-299038-e0nsol3y 196 9 virus virus NN cord-299038-e0nsol3y 196 10 particle particle NN cord-299038-e0nsol3y 196 11 membranes membrane NNS cord-299038-e0nsol3y 196 12 facilitates facilitate VBZ cord-299038-e0nsol3y 196 13 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 196 14 binding bind VBG cord-299038-e0nsol3y 196 15 to to IN cord-299038-e0nsol3y 196 16 mDC mdc NN cord-299038-e0nsol3y 196 17 and and CC cord-299038-e0nsol3y 196 18 may may MD cord-299038-e0nsol3y 196 19 be be VB cord-299038-e0nsol3y 196 20 a a DT cord-299038-e0nsol3y 196 21 conserved conserved JJ cord-299038-e0nsol3y 196 22 mechanism mechanism NN cord-299038-e0nsol3y 196 23 for for IN cord-299038-e0nsol3y 196 24 enveloped envelop VBN cord-299038-e0nsol3y 196 25 RNA RNA NNP cord-299038-e0nsol3y 196 26 viruses virus NNS cord-299038-e0nsol3y 196 27 to to TO cord-299038-e0nsol3y 196 28 exploit exploit VB cord-299038-e0nsol3y 196 29 mDC mDC NNS cord-299038-e0nsol3y 196 30 for for IN cord-299038-e0nsol3y 196 31 systemic systemic JJ cord-299038-e0nsol3y 196 32 virus virus NN cord-299038-e0nsol3y 196 33 dissemination dissemination NN cord-299038-e0nsol3y 196 34 . . . cord-299038-e0nsol3y 197 1 Finally finally RB cord-299038-e0nsol3y 197 2 , , , cord-299038-e0nsol3y 197 3 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 197 4 modulates modulate VBZ cord-299038-e0nsol3y 197 5 T T NNP cord-299038-e0nsol3y 197 6 cell cell NN cord-299038-e0nsol3y 197 7 - - HYPH cord-299038-e0nsol3y 197 8 mediated mediate VBN cord-299038-e0nsol3y 197 9 anti anti JJ cord-299038-e0nsol3y 197 10 - - JJ cord-299038-e0nsol3y 197 11 viral viral JJ cord-299038-e0nsol3y 197 12 responses response NNS cord-299038-e0nsol3y 197 13 during during IN cord-299038-e0nsol3y 197 14 human human JJ cord-299038-e0nsol3y 197 15 respiratory respiratory JJ cord-299038-e0nsol3y 197 16 syncytial syncytial JJ cord-299038-e0nsol3y 197 17 virus virus NN cord-299038-e0nsol3y 197 18 ( ( -LRB- cord-299038-e0nsol3y 197 19 RSV RSV NNP cord-299038-e0nsol3y 197 20 ) ) -RRB- cord-299038-e0nsol3y 197 21 infection infection NN cord-299038-e0nsol3y 197 22 , , , cord-299038-e0nsol3y 197 23 with with IN cord-299038-e0nsol3y 197 24 key key JJ cord-299038-e0nsol3y 197 25 differences difference NNS cord-299038-e0nsol3y 197 26 between between IN cord-299038-e0nsol3y 197 27 newborns newborn NNS cord-299038-e0nsol3y 197 28 and and CC cord-299038-e0nsol3y 197 29 adults adult NNS cord-299038-e0nsol3y 197 30 . . . cord-299038-e0nsol3y 198 1 Upon upon IN cord-299038-e0nsol3y 198 2 RSV RSV NNP cord-299038-e0nsol3y 198 3 infection infection NN cord-299038-e0nsol3y 198 4 , , , cord-299038-e0nsol3y 198 5 expression expression NN cord-299038-e0nsol3y 198 6 of of IN cord-299038-e0nsol3y 198 7 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 198 8 is be VBZ cord-299038-e0nsol3y 198 9 upregulated upregulate VBN cord-299038-e0nsol3y 198 10 on on IN cord-299038-e0nsol3y 198 11 monocytes monocyte NNS cord-299038-e0nsol3y 198 12 from from IN cord-299038-e0nsol3y 198 13 both both DT cord-299038-e0nsol3y 198 14 newborns newborn NNS cord-299038-e0nsol3y 198 15 and and CC cord-299038-e0nsol3y 198 16 adults adult NNS cord-299038-e0nsol3y 198 17 , , , cord-299038-e0nsol3y 198 18 whereas whereas IN cord-299038-e0nsol3y 198 19 expression expression NN cord-299038-e0nsol3y 198 20 of of IN cord-299038-e0nsol3y 198 21 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 198 22 ligand ligand NN cord-299038-e0nsol3y 198 23 , , , cord-299038-e0nsol3y 198 24 CD43 CD43 NNP cord-299038-e0nsol3y 198 25 , , , cord-299038-e0nsol3y 198 26 is be VBZ cord-299038-e0nsol3y 198 27 only only RB cord-299038-e0nsol3y 198 28 highly highly RB cord-299038-e0nsol3y 198 29 upregulated upregulate VBN cord-299038-e0nsol3y 198 30 on on IN cord-299038-e0nsol3y 198 31 adult adult NN cord-299038-e0nsol3y 198 32 CD4 CD4 NNP cord-299038-e0nsol3y 198 33 + + CC cord-299038-e0nsol3y 198 34 T t NN cord-299038-e0nsol3y 198 35 cells cell NNS cord-299038-e0nsol3y 198 36 ( ( -LRB- cord-299038-e0nsol3y 198 37 van van NNP cord-299038-e0nsol3y 198 38 den den NNP cord-299038-e0nsol3y 198 39 Berg Berg NNP cord-299038-e0nsol3y 198 40 et et NNP cord-299038-e0nsol3y 198 41 al al NNP cord-299038-e0nsol3y 198 42 . . NNP cord-299038-e0nsol3y 198 43 2001 2001 CD cord-299038-e0nsol3y 198 44 ; ; : cord-299038-e0nsol3y 198 45 Jans Jans NNP cord-299038-e0nsol3y 198 46 et et NNP cord-299038-e0nsol3y 198 47 al al NNP cord-299038-e0nsol3y 198 48 . . . cord-299038-e0nsol3y 198 49 2018 2018 CD cord-299038-e0nsol3y 198 50 ) ) -RRB- cord-299038-e0nsol3y 198 51 . . . cord-299038-e0nsol3y 199 1 This this DT cord-299038-e0nsol3y 199 2 finding finding NN cord-299038-e0nsol3y 199 3 is be VBZ cord-299038-e0nsol3y 199 4 consistent consistent JJ cord-299038-e0nsol3y 199 5 with with IN cord-299038-e0nsol3y 199 6 observations observation NNS cord-299038-e0nsol3y 199 7 that that WDT cord-299038-e0nsol3y 199 8 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 199 9 inhibits inhibit VBZ cord-299038-e0nsol3y 199 10 IFN IFN NNP cord-299038-e0nsol3y 199 11 - - HYPH cord-299038-e0nsol3y 199 12 γ γ NN cord-299038-e0nsol3y 199 13 production production NN cord-299038-e0nsol3y 199 14 by by IN cord-299038-e0nsol3y 199 15 adult adult NN cord-299038-e0nsol3y 199 16 CD4 CD4 NNP cord-299038-e0nsol3y 199 17 + + CC cord-299038-e0nsol3y 199 18 T t NN cord-299038-e0nsol3y 199 19 cells cell NNS cord-299038-e0nsol3y 199 20 but but CC cord-299038-e0nsol3y 199 21 not not RB cord-299038-e0nsol3y 199 22 newborn newborn JJ cord-299038-e0nsol3y 199 23 CD4 CD4 NNP cord-299038-e0nsol3y 199 24 + + CC cord-299038-e0nsol3y 199 25 T t NN cord-299038-e0nsol3y 199 26 cells cell NNS cord-299038-e0nsol3y 199 27 , , , cord-299038-e0nsol3y 199 28 although although IN cord-299038-e0nsol3y 199 29 the the DT cord-299038-e0nsol3y 199 30 detailed detailed JJ cord-299038-e0nsol3y 199 31 mechanism mechanism NN cord-299038-e0nsol3y 199 32 remains remain VBZ cord-299038-e0nsol3y 199 33 unknown unknown JJ cord-299038-e0nsol3y 199 34 ( ( -LRB- cord-299038-e0nsol3y 199 35 Jans Jans NNP cord-299038-e0nsol3y 199 36 et et NNP cord-299038-e0nsol3y 199 37 al al NNP cord-299038-e0nsol3y 199 38 . . . cord-299038-e0nsol3y 199 39 2018 2018 CD cord-299038-e0nsol3y 199 40 ) ) -RRB- cord-299038-e0nsol3y 199 41 . . . cord-299038-e0nsol3y 200 1 Unlike unlike IN cord-299038-e0nsol3y 200 2 many many JJ cord-299038-e0nsol3y 200 3 bacterial bacterial JJ cord-299038-e0nsol3y 200 4 and and CC cord-299038-e0nsol3y 200 5 viral viral JJ cord-299038-e0nsol3y 200 6 infections infection NNS cord-299038-e0nsol3y 200 7 , , , cord-299038-e0nsol3y 200 8 parasitic parasitic JJ cord-299038-e0nsol3y 200 9 diseases disease NNS cord-299038-e0nsol3y 200 10 caused cause VBN cord-299038-e0nsol3y 200 11 by by IN cord-299038-e0nsol3y 200 12 protozoa protozoan NNS cord-299038-e0nsol3y 200 13 and and CC cord-299038-e0nsol3y 200 14 helminths helminth NNS cord-299038-e0nsol3y 200 15 are be VBP cord-299038-e0nsol3y 200 16 often often RB cord-299038-e0nsol3y 200 17 chronic chronic JJ cord-299038-e0nsol3y 200 18 , , , cord-299038-e0nsol3y 200 19 lasting last VBG cord-299038-e0nsol3y 200 20 months month NNS cord-299038-e0nsol3y 200 21 to to IN cord-299038-e0nsol3y 200 22 years year NNS cord-299038-e0nsol3y 200 23 or or CC cord-299038-e0nsol3y 200 24 even even RB cord-299038-e0nsol3y 200 25 lifetimes lifetime NNS cord-299038-e0nsol3y 200 26 . . . cord-299038-e0nsol3y 201 1 Animal animal NN cord-299038-e0nsol3y 201 2 parasites parasite NNS cord-299038-e0nsol3y 201 3 have have VBP cord-299038-e0nsol3y 201 4 developed develop VBN cord-299038-e0nsol3y 201 5 remarkable remarkable JJ cord-299038-e0nsol3y 201 6 strategies strategy NNS cord-299038-e0nsol3y 201 7 to to TO cord-299038-e0nsol3y 201 8 interfere interfere VB cord-299038-e0nsol3y 201 9 with with IN cord-299038-e0nsol3y 201 10 or or CC cord-299038-e0nsol3y 201 11 avoid avoid VB cord-299038-e0nsol3y 201 12 immune immune JJ cord-299038-e0nsol3y 201 13 clearance clearance NN cord-299038-e0nsol3y 201 14 mechanisms mechanism NNS cord-299038-e0nsol3y 201 15 to to TO cord-299038-e0nsol3y 201 16 establish establish VB cord-299038-e0nsol3y 201 17 a a DT cord-299038-e0nsol3y 201 18 chronic chronic JJ cord-299038-e0nsol3y 201 19 infection infection NN cord-299038-e0nsol3y 201 20 in in IN cord-299038-e0nsol3y 201 21 their -PRON- PRP$ cord-299038-e0nsol3y 201 22 vertebrate vertebrate JJ cord-299038-e0nsol3y 201 23 hosts host NNS cord-299038-e0nsol3y 201 24 , , , cord-299038-e0nsol3y 201 25 including include VBG cord-299038-e0nsol3y 201 26 several several JJ cord-299038-e0nsol3y 201 27 examples example NNS cord-299038-e0nsol3y 201 28 of of IN cord-299038-e0nsol3y 201 29 Sia Sia NNP cord-299038-e0nsol3y 201 30 - - HYPH cord-299038-e0nsol3y 201 31 Siglec Siglec NNP cord-299038-e0nsol3y 201 32 - - HYPH cord-299038-e0nsol3y 201 33 mediated mediate VBN cord-299038-e0nsol3y 201 34 interactions interaction NNS cord-299038-e0nsol3y 201 35 that that WDT cord-299038-e0nsol3y 201 36 help help VBP cord-299038-e0nsol3y 201 37 achieve achieve VB cord-299038-e0nsol3y 201 38 this this DT cord-299038-e0nsol3y 201 39 immune immune JJ cord-299038-e0nsol3y 201 40 evasion evasion NN cord-299038-e0nsol3y 201 41 phenotype phenotype NN cord-299038-e0nsol3y 201 42 . . . cord-299038-e0nsol3y 202 1 The the DT cord-299038-e0nsol3y 202 2 protozoan protozoan NN cord-299038-e0nsol3y 202 3 parasite parasite NN cord-299038-e0nsol3y 202 4 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 202 5 cruzi cruzi NNP cord-299038-e0nsol3y 202 6 , , , cord-299038-e0nsol3y 202 7 the the DT cord-299038-e0nsol3y 202 8 causative causative JJ cord-299038-e0nsol3y 202 9 agent agent NN cord-299038-e0nsol3y 202 10 of of IN cord-299038-e0nsol3y 202 11 Chagas Chagas NNP cord-299038-e0nsol3y 202 12 disease disease NN cord-299038-e0nsol3y 202 13 , , , cord-299038-e0nsol3y 202 14 illustrates illustrate VBZ cord-299038-e0nsol3y 202 15 well well RB cord-299038-e0nsol3y 202 16 how how WRB cord-299038-e0nsol3y 202 17 Sia Sia NNP cord-299038-e0nsol3y 202 18 can can MD cord-299038-e0nsol3y 202 19 be be VB cord-299038-e0nsol3y 202 20 exploited exploit VBN cord-299038-e0nsol3y 202 21 by by IN cord-299038-e0nsol3y 202 22 animal animal NN cord-299038-e0nsol3y 202 23 parasites parasite NNS cord-299038-e0nsol3y 202 24 to to TO cord-299038-e0nsol3y 202 25 escape escape VB cord-299038-e0nsol3y 202 26 host host NN cord-299038-e0nsol3y 202 27 immune immune JJ cord-299038-e0nsol3y 202 28 surveillance surveillance NN cord-299038-e0nsol3y 202 29 , , , cord-299038-e0nsol3y 202 30 from from IN cord-299038-e0nsol3y 202 31 the the DT cord-299038-e0nsol3y 202 32 very very RB cord-299038-e0nsol3y 202 33 first first JJ cord-299038-e0nsol3y 202 34 encounter encounter NN cord-299038-e0nsol3y 202 35 with with IN cord-299038-e0nsol3y 202 36 innate innate JJ cord-299038-e0nsol3y 202 37 immune immune JJ cord-299038-e0nsol3y 202 38 cells cell NNS cord-299038-e0nsol3y 202 39 to to IN cord-299038-e0nsol3y 202 40 the the DT cord-299038-e0nsol3y 202 41 late late RB cord-299038-e0nsol3y 202 42 - - HYPH cord-299038-e0nsol3y 202 43 mounted mount VBN cord-299038-e0nsol3y 202 44 adaptive adaptive JJ cord-299038-e0nsol3y 202 45 immune immune JJ cord-299038-e0nsol3y 202 46 responses response NNS cord-299038-e0nsol3y 202 47 . . . cord-299038-e0nsol3y 203 1 Although although IN cord-299038-e0nsol3y 203 2 T. T. NNP cord-299038-e0nsol3y 203 3 cruzi cruzi NNP cord-299038-e0nsol3y 203 4 can can MD cord-299038-e0nsol3y 203 5 not not RB cord-299038-e0nsol3y 203 6 synthesize synthesize VB cord-299038-e0nsol3y 203 7 Sias Sias NNP cord-299038-e0nsol3y 203 8 de de NNP cord-299038-e0nsol3y 203 9 novo novo NNP cord-299038-e0nsol3y 203 10 , , , cord-299038-e0nsol3y 203 11 it -PRON- PRP cord-299038-e0nsol3y 203 12 uses use VBZ cord-299038-e0nsol3y 203 13 its -PRON- PRP$ cord-299038-e0nsol3y 203 14 trans trans NNP cord-299038-e0nsol3y 203 15 - - NNP cord-299038-e0nsol3y 203 16 sialidase sialidase JJ cord-299038-e0nsol3y 203 17 ( ( -LRB- cord-299038-e0nsol3y 203 18 TcTS TcTS NNP cord-299038-e0nsol3y 203 19 ) ) -RRB- cord-299038-e0nsol3y 203 20 enzyme enzyme NN cord-299038-e0nsol3y 203 21 to to TO cord-299038-e0nsol3y 203 22 transfer transfer VB cord-299038-e0nsol3y 203 23 Sias Sias NNP cord-299038-e0nsol3y 203 24 from from IN cord-299038-e0nsol3y 203 25 host host NN cord-299038-e0nsol3y 203 26 sialylglycoconjugates sialylglycoconjugate NNS cord-299038-e0nsol3y 203 27 to to IN cord-299038-e0nsol3y 203 28 its -PRON- PRP$ cord-299038-e0nsol3y 203 29 own own JJ cord-299038-e0nsol3y 203 30 surface surface NN cord-299038-e0nsol3y 203 31 mucins mucin NNS cord-299038-e0nsol3y 203 32 ( ( -LRB- cord-299038-e0nsol3y 203 33 Pereira Pereira NNP cord-299038-e0nsol3y 203 34 1983 1983 CD cord-299038-e0nsol3y 203 35 ; ; : cord-299038-e0nsol3y 203 36 Pereira Pereira NNP cord-299038-e0nsol3y 203 37 et et NNP cord-299038-e0nsol3y 203 38 al al NNP cord-299038-e0nsol3y 203 39 . . . cord-299038-e0nsol3y 203 40 1980 1980 CD cord-299038-e0nsol3y 203 41 ) ) -RRB- cord-299038-e0nsol3y 203 42 . . . cord-299038-e0nsol3y 204 1 These these DT cord-299038-e0nsol3y 204 2 highly highly RB cord-299038-e0nsol3y 204 3 sialylated sialylated JJ cord-299038-e0nsol3y 204 4 mucin mucin NN cord-299038-e0nsol3y 204 5 - - HYPH cord-299038-e0nsol3y 204 6 like like JJ cord-299038-e0nsol3y 204 7 coats coat NNS cord-299038-e0nsol3y 204 8 generated generate VBN cord-299038-e0nsol3y 204 9 on on IN cord-299038-e0nsol3y 204 10 the the DT cord-299038-e0nsol3y 204 11 T. T. NNP cord-299038-e0nsol3y 204 12 cruzi cruzi NN cord-299038-e0nsol3y 204 13 surface surface NN cord-299038-e0nsol3y 204 14 confer confer VB cord-299038-e0nsol3y 204 15 resistance resistance NN cord-299038-e0nsol3y 204 16 to to IN cord-299038-e0nsol3y 204 17 complement complement NN cord-299038-e0nsol3y 204 18 - - HYPH cord-299038-e0nsol3y 204 19 mediated mediate VBN cord-299038-e0nsol3y 204 20 killing killing NN cord-299038-e0nsol3y 204 21 by by IN cord-299038-e0nsol3y 204 22 impeding impede VBG cord-299038-e0nsol3y 204 23 C3 C3 NNP cord-299038-e0nsol3y 204 24 convertase convertase NN cord-299038-e0nsol3y 204 25 assembly assembly NN cord-299038-e0nsol3y 204 26 , , , cord-299038-e0nsol3y 204 27 and and CC cord-299038-e0nsol3y 204 28 block block VB cord-299038-e0nsol3y 204 29 potential potential JJ cord-299038-e0nsol3y 204 30 lytic lytic JJ cord-299038-e0nsol3y 204 31 effects effect NNS cord-299038-e0nsol3y 204 32 of of IN cord-299038-e0nsol3y 204 33 host host NN cord-299038-e0nsol3y 204 34 anti anti JJ cord-299038-e0nsol3y 204 35 - - JJ cord-299038-e0nsol3y 204 36 α α JJ cord-299038-e0nsol3y 204 37 - - HYPH cord-299038-e0nsol3y 204 38 Gal gal NN cord-299038-e0nsol3y 204 39 antibodies antibody NNS cord-299038-e0nsol3y 204 40 that that WDT cord-299038-e0nsol3y 204 41 would would MD cord-299038-e0nsol3y 204 42 recognize recognize VB cord-299038-e0nsol3y 204 43 the the DT cord-299038-e0nsol3y 204 44 otherwise otherwise RB cord-299038-e0nsol3y 204 45 exposed expose VBN cord-299038-e0nsol3y 204 46 α α NN cord-299038-e0nsol3y 204 47 - - HYPH cord-299038-e0nsol3y 204 48 galactosyl galactosyl NNP cord-299038-e0nsol3y 204 49 epitopes epitope NNS cord-299038-e0nsol3y 204 50 on on IN cord-299038-e0nsol3y 204 51 the the DT cord-299038-e0nsol3y 204 52 mucin mucin NN cord-299038-e0nsol3y 204 53 - - HYPH cord-299038-e0nsol3y 204 54 like like JJ cord-299038-e0nsol3y 204 55 glycoproteins glycoprotein NNS cord-299038-e0nsol3y 204 56 ( ( -LRB- cord-299038-e0nsol3y 204 57 Pereira Pereira NNP cord-299038-e0nsol3y 204 58 - - HYPH cord-299038-e0nsol3y 204 59 Chioccola Chioccola NNP cord-299038-e0nsol3y 204 60 et et NNP cord-299038-e0nsol3y 204 61 al al NNP cord-299038-e0nsol3y 204 62 . . . cord-299038-e0nsol3y 204 63 2000 2000 CD cord-299038-e0nsol3y 204 64 ; ; : cord-299038-e0nsol3y 204 65 Tomlinson Tomlinson NNP cord-299038-e0nsol3y 204 66 et et NNP cord-299038-e0nsol3y 204 67 al al NNP cord-299038-e0nsol3y 204 68 . . . cord-299038-e0nsol3y 204 69 1994 1994 CD cord-299038-e0nsol3y 204 70 ) ) -RRB- cord-299038-e0nsol3y 204 71 . . . cord-299038-e0nsol3y 205 1 Moreover moreover RB cord-299038-e0nsol3y 205 2 , , , cord-299038-e0nsol3y 205 3 T. T. NNP cord-299038-e0nsol3y 205 4 cruzi cruzi NNP cord-299038-e0nsol3y 205 5 sialyl sialyl NNP cord-299038-e0nsol3y 205 6 - - HYPH cord-299038-e0nsol3y 205 7 glycoconjugates glycoconjugate NNS cord-299038-e0nsol3y 205 8 facilitate facilitate VBP cord-299038-e0nsol3y 205 9 its -PRON- PRP$ cord-299038-e0nsol3y 205 10 binding binding NN cord-299038-e0nsol3y 205 11 to to IN cord-299038-e0nsol3y 205 12 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 205 13 on on IN cord-299038-e0nsol3y 205 14 host host NN cord-299038-e0nsol3y 205 15 macrophages macrophage NNS cord-299038-e0nsol3y 205 16 , , , cord-299038-e0nsol3y 205 17 and and CC cord-299038-e0nsol3y 205 18 this this DT cord-299038-e0nsol3y 205 19 interaction interaction NN cord-299038-e0nsol3y 205 20 may may MD cord-299038-e0nsol3y 205 21 be be VB cord-299038-e0nsol3y 205 22 involved involve VBN cord-299038-e0nsol3y 205 23 in in IN cord-299038-e0nsol3y 205 24 the the DT cord-299038-e0nsol3y 205 25 initiation initiation NN cord-299038-e0nsol3y 205 26 of of IN cord-299038-e0nsol3y 205 27 trypomastigote trypomastigote NNP cord-299038-e0nsol3y 205 28 infection infection NN cord-299038-e0nsol3y 205 29 ( ( -LRB- cord-299038-e0nsol3y 205 30 Monteiro Monteiro NNP cord-299038-e0nsol3y 205 31 et et NNP cord-299038-e0nsol3y 205 32 al al NNP cord-299038-e0nsol3y 205 33 . . NNP cord-299038-e0nsol3y 205 34 2005 2005 CD cord-299038-e0nsol3y 205 35 ) ) -RRB- cord-299038-e0nsol3y 205 36 . . . cord-299038-e0nsol3y 206 1 T. T. NNP cord-299038-e0nsol3y 206 2 cruzi cruzi NNP cord-299038-e0nsol3y 206 3 can can MD cord-299038-e0nsol3y 206 4 also also RB cord-299038-e0nsol3y 206 5 use use VB cord-299038-e0nsol3y 206 6 its -PRON- PRP$ cord-299038-e0nsol3y 206 7 surface surface NN cord-299038-e0nsol3y 206 8 sialyl sialyl NNS cord-299038-e0nsol3y 206 9 - - HYPH cord-299038-e0nsol3y 206 10 glycoconjugates glycoconjugate NNS cord-299038-e0nsol3y 206 11 to to TO cord-299038-e0nsol3y 206 12 engage engage VB cord-299038-e0nsol3y 206 13 Siglec Siglec NNP cord-299038-e0nsol3y 206 14 - - HYPH cord-299038-e0nsol3y 206 15 E E NNP cord-299038-e0nsol3y 206 16 on on IN cord-299038-e0nsol3y 206 17 DCs dc NNS cord-299038-e0nsol3y 206 18 and and CC cord-299038-e0nsol3y 206 19 actively actively RB cord-299038-e0nsol3y 206 20 suppress suppress VB cord-299038-e0nsol3y 206 21 their -PRON- PRP$ cord-299038-e0nsol3y 206 22 production production NN cord-299038-e0nsol3y 206 23 of of IN cord-299038-e0nsol3y 206 24 proinflammatory proinflammatory JJ cord-299038-e0nsol3y 206 25 cytokine cytokine NN cord-299038-e0nsol3y 206 26 IL-12 IL-12 NNP cord-299038-e0nsol3y 206 27 , , , cord-299038-e0nsol3y 206 28 impairing impair VBG cord-299038-e0nsol3y 206 29 generation generation NN cord-299038-e0nsol3y 206 30 of of IN cord-299038-e0nsol3y 206 31 protective protective JJ cord-299038-e0nsol3y 206 32 Th1 th1 NN cord-299038-e0nsol3y 206 33 responses response NNS cord-299038-e0nsol3y 206 34 ( ( -LRB- cord-299038-e0nsol3y 206 35 Erdmann Erdmann NNP cord-299038-e0nsol3y 206 36 et et FW cord-299038-e0nsol3y 206 37 al al NNP cord-299038-e0nsol3y 206 38 . . NNP cord-299038-e0nsol3y 206 39 2009 2009 CD cord-299038-e0nsol3y 206 40 ) ) -RRB- cord-299038-e0nsol3y 206 41 . . . cord-299038-e0nsol3y 207 1 Presence presence NN cord-299038-e0nsol3y 207 2 of of IN cord-299038-e0nsol3y 207 3 α2 α2 NNP cord-299038-e0nsol3y 207 4 - - HYPH cord-299038-e0nsol3y 207 5 3 3 CD cord-299038-e0nsol3y 207 6 and and CC cord-299038-e0nsol3y 207 7 α2 α2 NNP cord-299038-e0nsol3y 207 8 - - HYPH cord-299038-e0nsol3y 207 9 6 6 CD cord-299038-e0nsol3y 207 10 linked link VBN cord-299038-e0nsol3y 207 11 sialoglycans sialoglycans NNPS cord-299038-e0nsol3y 207 12 has have VBZ cord-299038-e0nsol3y 207 13 also also RB cord-299038-e0nsol3y 207 14 been be VBN cord-299038-e0nsol3y 207 15 discovered discover VBN cord-299038-e0nsol3y 207 16 on on IN cord-299038-e0nsol3y 207 17 another another DT cord-299038-e0nsol3y 207 18 flagellated flagellated JJ cord-299038-e0nsol3y 207 19 protozoa protozoan NNS cord-299038-e0nsol3y 207 20 , , , cord-299038-e0nsol3y 207 21 Leishmania Leishmania NNP cord-299038-e0nsol3y 207 22 donovani donovani NNP cord-299038-e0nsol3y 207 23 , , , cord-299038-e0nsol3y 207 24 the the DT cord-299038-e0nsol3y 207 25 causative causative JJ cord-299038-e0nsol3y 207 26 organism organism NN cord-299038-e0nsol3y 207 27 of of IN cord-299038-e0nsol3y 207 28 Indian indian JJ cord-299038-e0nsol3y 207 29 visceral visceral JJ cord-299038-e0nsol3y 207 30 leishmaniasis leishmaniasis NN cord-299038-e0nsol3y 208 1 ( ( -LRB- cord-299038-e0nsol3y 208 2 Chatterjee Chatterjee NNP cord-299038-e0nsol3y 208 3 et et NNP cord-299038-e0nsol3y 208 4 al al NNP cord-299038-e0nsol3y 208 5 . . NNP cord-299038-e0nsol3y 208 6 2003 2003 CD cord-299038-e0nsol3y 208 7 ) ) -RRB- cord-299038-e0nsol3y 208 8 , , , cord-299038-e0nsol3y 208 9 such such JJ cord-299038-e0nsol3y 208 10 that that IN cord-299038-e0nsol3y 208 11 high high JJ cord-299038-e0nsol3y 208 12 Sia Sia NNP cord-299038-e0nsol3y 208 13 - - HYPH cord-299038-e0nsol3y 208 14 containing contain VBG cord-299038-e0nsol3y 208 15 virulent virulent JJ cord-299038-e0nsol3y 208 16 strains strain NNS cord-299038-e0nsol3y 208 17 bind bind VBP cord-299038-e0nsol3y 208 18 both both DT cord-299038-e0nsol3y 208 19 Siglec-1 Siglec-1 NNPS cord-299038-e0nsol3y 208 20 and and CC cord-299038-e0nsol3y 208 21 Siglec-5 Siglec-5 NNPS cord-299038-e0nsol3y 208 22 . . . cord-299038-e0nsol3y 209 1 The the DT cord-299038-e0nsol3y 209 2 Sia Sia NNP cord-299038-e0nsol3y 209 3 - - HYPH cord-299038-e0nsol3y 209 4 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 209 5 interaction interaction NN cord-299038-e0nsol3y 209 6 promotes promote VBZ cord-299038-e0nsol3y 209 7 macrophage macrophage NN cord-299038-e0nsol3y 209 8 uptake uptake NN cord-299038-e0nsol3y 209 9 of of IN cord-299038-e0nsol3y 209 10 the the DT cord-299038-e0nsol3y 209 11 parasite parasite NN cord-299038-e0nsol3y 209 12 promoting promote VBG cord-299038-e0nsol3y 209 13 dissemination dissemination NN cord-299038-e0nsol3y 209 14 to to IN cord-299038-e0nsol3y 209 15 other other JJ cord-299038-e0nsol3y 209 16 sites site NNS cord-299038-e0nsol3y 209 17 within within IN cord-299038-e0nsol3y 209 18 the the DT cord-299038-e0nsol3y 209 19 body body NN cord-299038-e0nsol3y 209 20 , , , cord-299038-e0nsol3y 209 21 whereas whereas IN cord-299038-e0nsol3y 209 22 the the DT cord-299038-e0nsol3y 209 23 Sia Sia NNP cord-299038-e0nsol3y 209 24 - - HYPH cord-299038-e0nsol3y 209 25 Siglec-5 Siglec-5 NNP cord-299038-e0nsol3y 209 26 binding binding NN cord-299038-e0nsol3y 209 27 suppresses suppress VBZ cord-299038-e0nsol3y 209 28 ROS ROS NNP cord-299038-e0nsol3y 209 29 , , , cord-299038-e0nsol3y 209 30 NO no UH cord-299038-e0nsol3y 209 31 , , , cord-299038-e0nsol3y 209 32 and and CC cord-299038-e0nsol3y 209 33 Th2-dominant th2-dominant JJ cord-299038-e0nsol3y 209 34 cytokine cytokine NN cord-299038-e0nsol3y 209 35 responses response NNS cord-299038-e0nsol3y 209 36 in in IN cord-299038-e0nsol3y 209 37 infected infected JJ cord-299038-e0nsol3y 209 38 macrophages macrophage NNS cord-299038-e0nsol3y 209 39 by by IN cord-299038-e0nsol3y 209 40 counteracting counteract VBG cord-299038-e0nsol3y 209 41 MAPK MAPK NNP cord-299038-e0nsol3y 209 42 and and CC cord-299038-e0nsol3y 209 43 PI3K PI3K NNP cord-299038-e0nsol3y 209 44 / / SYM cord-299038-e0nsol3y 209 45 Akt Akt NNP cord-299038-e0nsol3y 209 46 signaling signal VBG cord-299038-e0nsol3y 209 47 pathways pathway NNS cord-299038-e0nsol3y 209 48 ( ( -LRB- cord-299038-e0nsol3y 209 49 Roy Roy NNP cord-299038-e0nsol3y 209 50 and and CC cord-299038-e0nsol3y 209 51 Mandal Mandal NNP cord-299038-e0nsol3y 209 52 2016 2016 CD cord-299038-e0nsol3y 209 53 ) ) -RRB- cord-299038-e0nsol3y 209 54 . . . cord-299038-e0nsol3y 210 1 Lastly lastly RB cord-299038-e0nsol3y 210 2 , , , cord-299038-e0nsol3y 210 3 vaginitis vaginitis NN cord-299038-e0nsol3y 210 4 caused cause VBN cord-299038-e0nsol3y 210 5 by by IN cord-299038-e0nsol3y 210 6 the the DT cord-299038-e0nsol3y 210 7 fungal fungal JJ cord-299038-e0nsol3y 210 8 pathogen pathogen NN cord-299038-e0nsol3y 210 9 Candida Candida NNP cord-299038-e0nsol3y 210 10 is be VBZ cord-299038-e0nsol3y 210 11 common common JJ cord-299038-e0nsol3y 210 12 and and CC cord-299038-e0nsol3y 210 13 frequently frequently RB cord-299038-e0nsol3y 210 14 recurrent recurrent JJ cord-299038-e0nsol3y 210 15 condition condition NN cord-299038-e0nsol3y 210 16 in in IN cord-299038-e0nsol3y 210 17 women woman NNS cord-299038-e0nsol3y 210 18 's 's POS cord-299038-e0nsol3y 210 19 health health NN cord-299038-e0nsol3y 210 20 . . . cord-299038-e0nsol3y 211 1 Recently recently RB cord-299038-e0nsol3y 211 2 , , , cord-299038-e0nsol3y 211 3 a a DT cord-299038-e0nsol3y 211 4 combined combine VBN cord-299038-e0nsol3y 211 5 global global JJ cord-299038-e0nsol3y 211 6 genetic genetic JJ cord-299038-e0nsol3y 211 7 and and CC cord-299038-e0nsol3y 211 8 immune immune JJ cord-299038-e0nsol3y 211 9 profiling profiling NN cord-299038-e0nsol3y 211 10 study study NN cord-299038-e0nsol3y 211 11 of of IN cord-299038-e0nsol3y 211 12 clinical clinical JJ cord-299038-e0nsol3y 211 13 populations population NNS cord-299038-e0nsol3y 211 14 identified identify VBD cord-299038-e0nsol3y 211 15 polymorphisms polymorphism NNS cord-299038-e0nsol3y 211 16 in in IN cord-299038-e0nsol3y 211 17 SIGLEC15 SIGLEC15 NNP cord-299038-e0nsol3y 211 18 as as IN cord-299038-e0nsol3y 211 19 candidate candidate NN cord-299038-e0nsol3y 211 20 genetic genetic JJ cord-299038-e0nsol3y 211 21 predispositions predisposition NNS cord-299038-e0nsol3y 211 22 involved involve VBN cord-299038-e0nsol3y 211 23 in in IN cord-299038-e0nsol3y 211 24 Candida Candida NNP cord-299038-e0nsol3y 211 25 vaginitis vaginitis NN cord-299038-e0nsol3y 211 26 susceptibility susceptibility NN cord-299038-e0nsol3y 212 1 ( ( -LRB- cord-299038-e0nsol3y 212 2 Jaeger Jaeger NNP cord-299038-e0nsol3y 212 3 et et NNP cord-299038-e0nsol3y 212 4 al al NNP cord-299038-e0nsol3y 212 5 . . . cord-299038-e0nsol3y 212 6 2019 2019 CD cord-299038-e0nsol3y 212 7 ) ) -RRB- cord-299038-e0nsol3y 212 8 . . . cord-299038-e0nsol3y 213 1 A a DT cord-299038-e0nsol3y 213 2 particular particular JJ cord-299038-e0nsol3y 213 3 SIGLEC15 SIGLEC15 NNP cord-299038-e0nsol3y 213 4 polymorphism polymorphism NN cord-299038-e0nsol3y 213 5 was be VBD cord-299038-e0nsol3y 213 6 associated associate VBN cord-299038-e0nsol3y 213 7 with with IN cord-299038-e0nsol3y 213 8 great great JJ cord-299038-e0nsol3y 213 9 inflammasome inflammasome NN cord-299038-e0nsol3y 213 10 signaling signaling NN cord-299038-e0nsol3y 213 11 and and CC cord-299038-e0nsol3y 213 12 IL-1β il-1β JJ cord-299038-e0nsol3y 213 13 production production NN cord-299038-e0nsol3y 213 14 in in IN cord-299038-e0nsol3y 213 15 response response NN cord-299038-e0nsol3y 213 16 to to IN cord-299038-e0nsol3y 213 17 Candida Candida NNP cord-299038-e0nsol3y 213 18 in in IN cord-299038-e0nsol3y 213 19 vitro vitro FW cord-299038-e0nsol3y 213 20 , , , cord-299038-e0nsol3y 213 21 and and CC cord-299038-e0nsol3y 213 22 in in IN cord-299038-e0nsol3y 213 23 vivo vivo NN cord-299038-e0nsol3y 213 24 silencing silencing NN cord-299038-e0nsol3y 213 25 of of IN cord-299038-e0nsol3y 213 26 Siglec15 Siglec15 NNP cord-299038-e0nsol3y 213 27 in in IN cord-299038-e0nsol3y 213 28 a a DT cord-299038-e0nsol3y 213 29 murine murine JJ cord-299038-e0nsol3y 213 30 vaginitis vaginitis NN cord-299038-e0nsol3y 213 31 model model NN cord-299038-e0nsol3y 213 32 was be VBD cord-299038-e0nsol3y 213 33 associated associate VBN cord-299038-e0nsol3y 213 34 with with IN cord-299038-e0nsol3y 213 35 increased increase VBN cord-299038-e0nsol3y 213 36 fungal fungal JJ cord-299038-e0nsol3y 213 37 burden burden NN cord-299038-e0nsol3y 213 38 and and CC cord-299038-e0nsol3y 213 39 neutrophilic neutrophilic JJ cord-299038-e0nsol3y 213 40 inflammation inflammation NN cord-299038-e0nsol3y 214 1 ( ( -LRB- cord-299038-e0nsol3y 214 2 Jaeger Jaeger NNP cord-299038-e0nsol3y 214 3 et et NNP cord-299038-e0nsol3y 214 4 al al NNP cord-299038-e0nsol3y 214 5 . . . cord-299038-e0nsol3y 214 6 2019 2019 CD cord-299038-e0nsol3y 214 7 ) ) -RRB- cord-299038-e0nsol3y 214 8 . . . cord-299038-e0nsol3y 215 1 Recent recent JJ cord-299038-e0nsol3y 215 2 evidence evidence NN cord-299038-e0nsol3y 215 3 indicates indicate VBZ cord-299038-e0nsol3y 215 4 that that IN cord-299038-e0nsol3y 215 5 Siglecs Siglecs NNP cord-299038-e0nsol3y 215 6 functionally functionally RB cord-299038-e0nsol3y 215 7 intersect intersect VBP cord-299038-e0nsol3y 215 8 with with IN cord-299038-e0nsol3y 215 9 other other JJ cord-299038-e0nsol3y 215 10 host host NN cord-299038-e0nsol3y 215 11 innate innate JJ cord-299038-e0nsol3y 215 12 immune immune JJ cord-299038-e0nsol3y 215 13 sensing sensing NN cord-299038-e0nsol3y 215 14 pathways pathway NNS cord-299038-e0nsol3y 215 15 to to TO cord-299038-e0nsol3y 215 16 modulate modulate VB cord-299038-e0nsol3y 215 17 the the DT cord-299038-e0nsol3y 215 18 response response NN cord-299038-e0nsol3y 215 19 to to IN cord-299038-e0nsol3y 215 20 viral viral JJ cord-299038-e0nsol3y 215 21 and and CC cord-299038-e0nsol3y 215 22 bacterial bacterial JJ cord-299038-e0nsol3y 215 23 infection infection NN cord-299038-e0nsol3y 215 24 in in IN cord-299038-e0nsol3y 215 25 important important JJ cord-299038-e0nsol3y 215 26 ways way NNS cord-299038-e0nsol3y 215 27 . . . cord-299038-e0nsol3y 216 1 For for IN cord-299038-e0nsol3y 216 2 example example NN cord-299038-e0nsol3y 216 3 , , , cord-299038-e0nsol3y 216 4 the the DT cord-299038-e0nsol3y 216 5 RNA RNA NNP cord-299038-e0nsol3y 216 6 virus virus NN cord-299038-e0nsol3y 216 7 vesicular vesicular JJ cord-299038-e0nsol3y 216 8 stomatitis stomatitis NN cord-299038-e0nsol3y 216 9 virus virus NN cord-299038-e0nsol3y 216 10 ( ( -LRB- cord-299038-e0nsol3y 216 11 VSV VSV NNP cord-299038-e0nsol3y 216 12 ) ) -RRB- cord-299038-e0nsol3y 216 13 upregulates upregulate VBZ cord-299038-e0nsol3y 216 14 Siglec Siglec NNP cord-299038-e0nsol3y 216 15 - - HYPH cord-299038-e0nsol3y 216 16 G G NNP cord-299038-e0nsol3y 216 17 expression expression NN cord-299038-e0nsol3y 216 18 in in IN cord-299038-e0nsol3y 216 19 macrophages macrophage NNS cord-299038-e0nsol3y 216 20 through through IN cord-299038-e0nsol3y 216 21 intracellular intracellular JJ cord-299038-e0nsol3y 216 22 nucleic nucleic JJ cord-299038-e0nsol3y 216 23 acid acid NN cord-299038-e0nsol3y 216 24 sensor sensor NN cord-299038-e0nsol3y 216 25 RIG rig NN cord-299038-e0nsol3y 216 26 - - HYPH cord-299038-e0nsol3y 216 27 I I NNP cord-299038-e0nsol3y 216 28 - - HYPH cord-299038-e0nsol3y 216 29 or or CC cord-299038-e0nsol3y 216 30 NF nf NN cord-299038-e0nsol3y 216 31 - - HYPH cord-299038-e0nsol3y 216 32 κB κB NNP cord-299038-e0nsol3y 216 33 - - HYPH cord-299038-e0nsol3y 216 34 dependent dependent JJ cord-299038-e0nsol3y 216 35 mechanisms mechanism NNS cord-299038-e0nsol3y 217 1 ( ( -LRB- cord-299038-e0nsol3y 217 2 Chen Chen NNP cord-299038-e0nsol3y 217 3 et et NNP cord-299038-e0nsol3y 217 4 al al NNP cord-299038-e0nsol3y 217 5 . . NNP cord-299038-e0nsol3y 217 6 2013 2013 CD cord-299038-e0nsol3y 217 7 ) ) -RRB- cord-299038-e0nsol3y 217 8 . . . cord-299038-e0nsol3y 218 1 Subsequent subsequent JJ cord-299038-e0nsol3y 218 2 recruitment recruitment NN cord-299038-e0nsol3y 218 3 of of IN cord-299038-e0nsol3y 218 4 SHP-2 SHP-2 NNP cord-299038-e0nsol3y 218 5 phosphatase phosphatase NN cord-299038-e0nsol3y 218 6 to to IN cord-299038-e0nsol3y 218 7 the the DT cord-299038-e0nsol3y 218 8 Siglec Siglec NNP cord-299038-e0nsol3y 218 9 - - HYPH cord-299038-e0nsol3y 218 10 G G NNP cord-299038-e0nsol3y 218 11 intracellular intracellular JJ cord-299038-e0nsol3y 218 12 domain domain NN cord-299038-e0nsol3y 218 13 initiates initiate VBZ cord-299038-e0nsol3y 218 14 a a DT cord-299038-e0nsol3y 218 15 pathway pathway NN cord-299038-e0nsol3y 218 16 for for IN cord-299038-e0nsol3y 218 17 RIG rig NN cord-299038-e0nsol3y 218 18 - - : cord-299038-e0nsol3y 218 19 I -PRON- PRP cord-299038-e0nsol3y 218 20 degradation degradation NN cord-299038-e0nsol3y 218 21 , , , cord-299038-e0nsol3y 218 22 thus thus RB cord-299038-e0nsol3y 218 23 suppressing suppress VBG cord-299038-e0nsol3y 218 24 anti anti JJ cord-299038-e0nsol3y 218 25 - - JJ cord-299038-e0nsol3y 218 26 viral viral JJ cord-299038-e0nsol3y 218 27 immunity immunity NN cord-299038-e0nsol3y 218 28 . . . cord-299038-e0nsol3y 219 1 In in IN cord-299038-e0nsol3y 219 2 corroboration corroboration NN cord-299038-e0nsol3y 219 3 , , , cord-299038-e0nsol3y 219 4 inactivation inactivation NN cord-299038-e0nsol3y 219 5 of of IN cord-299038-e0nsol3y 219 6 Siglec Siglec NNP cord-299038-e0nsol3y 219 7 - - HYPH cord-299038-e0nsol3y 219 8 G G NNP cord-299038-e0nsol3y 219 9 protects protect VBZ cord-299038-e0nsol3y 219 10 mice mouse NNS cord-299038-e0nsol3y 219 11 against against IN cord-299038-e0nsol3y 219 12 lethal lethal JJ cord-299038-e0nsol3y 219 13 VSV VSV NNP cord-299038-e0nsol3y 219 14 infection infection NN cord-299038-e0nsol3y 220 1 ( ( -LRB- cord-299038-e0nsol3y 220 2 Chen Chen NNP cord-299038-e0nsol3y 220 3 et et NNP cord-299038-e0nsol3y 220 4 al al NNP cord-299038-e0nsol3y 220 5 . . NNP cord-299038-e0nsol3y 220 6 2013 2013 CD cord-299038-e0nsol3y 220 7 ) ) -RRB- cord-299038-e0nsol3y 220 8 . . . cord-299038-e0nsol3y 221 1 VSV VSV NNP cord-299038-e0nsol3y 221 2 infection infection NN cord-299038-e0nsol3y 221 3 also also RB cord-299038-e0nsol3y 221 4 results result VBZ cord-299038-e0nsol3y 221 5 in in IN cord-299038-e0nsol3y 221 6 upregulation upregulation NN cord-299038-e0nsol3y 221 7 of of IN cord-299038-e0nsol3y 221 8 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 221 9 in in IN cord-299038-e0nsol3y 221 10 macrophages macrophage NNS cord-299038-e0nsol3y 221 11 , , , cord-299038-e0nsol3y 221 12 which which WDT cord-299038-e0nsol3y 221 13 triggers trigger VBZ cord-299038-e0nsol3y 221 14 a a DT cord-299038-e0nsol3y 221 15 negative negative JJ cord-299038-e0nsol3y 221 16 regulation regulation NN cord-299038-e0nsol3y 221 17 pathway pathway NN cord-299038-e0nsol3y 221 18 for for IN cord-299038-e0nsol3y 221 19 TBK1 TBK1 NNP cord-299038-e0nsol3y 221 20 degradation degradation NN cord-299038-e0nsol3y 221 21 via via IN cord-299038-e0nsol3y 221 22 the the DT cord-299038-e0nsol3y 221 23 ubiquitin ubiquitin NN cord-299038-e0nsol3y 221 24 ligase ligase NN cord-299038-e0nsol3y 221 25 TRIM27 TRIM27 NNP cord-299038-e0nsol3y 221 26 , , , cord-299038-e0nsol3y 221 27 suppressing suppress VBG cord-299038-e0nsol3y 221 28 type type NN cord-299038-e0nsol3y 221 29 I -PRON- PRP cord-299038-e0nsol3y 221 30 interferon interferon VBD cord-299038-e0nsol3y 221 31 production production NN cord-299038-e0nsol3y 221 32 and and CC cord-299038-e0nsol3y 221 33 allowing allow VBG cord-299038-e0nsol3y 221 34 the the DT cord-299038-e0nsol3y 221 35 virus virus NN cord-299038-e0nsol3y 221 36 to to TO cord-299038-e0nsol3y 221 37 escape escape VB cord-299038-e0nsol3y 221 38 immune immune JJ cord-299038-e0nsol3y 221 39 elimination elimination NN cord-299038-e0nsol3y 221 40 ( ( -LRB- cord-299038-e0nsol3y 221 41 Zheng Zheng NNP cord-299038-e0nsol3y 221 42 et et FW cord-299038-e0nsol3y 221 43 al al NNP cord-299038-e0nsol3y 221 44 . . NNP cord-299038-e0nsol3y 221 45 2015 2015 CD cord-299038-e0nsol3y 221 46 ) ) -RRB- cord-299038-e0nsol3y 221 47 . . . cord-299038-e0nsol3y 222 1 Siglec Siglec NNP cord-299038-e0nsol3y 222 2 - - HYPH cord-299038-e0nsol3y 222 3 G G NNP cord-299038-e0nsol3y 222 4 expression expression NN cord-299038-e0nsol3y 222 5 is be VBZ cord-299038-e0nsol3y 222 6 low low JJ cord-299038-e0nsol3y 222 7 in in IN cord-299038-e0nsol3y 222 8 CD8α CD8α NNP cord-299038-e0nsol3y 222 9 + + CC cord-299038-e0nsol3y 222 10 DCs dc NNS cord-299038-e0nsol3y 222 11 , , , cord-299038-e0nsol3y 222 12 and and CC cord-299038-e0nsol3y 222 13 Siglec Siglec NNP cord-299038-e0nsol3y 222 14 - - HYPH cord-299038-e0nsol3y 222 15 G G NNP cord-299038-e0nsol3y 222 16 deficient deficient JJ cord-299038-e0nsol3y 222 17 mice mouse NNS cord-299038-e0nsol3y 222 18 generate generate VBP cord-299038-e0nsol3y 222 19 more more JJR cord-299038-e0nsol3y 222 20 antigen antigen NN cord-299038-e0nsol3y 222 21 - - HYPH cord-299038-e0nsol3y 222 22 specific specific JJ cord-299038-e0nsol3y 222 23 cytotoxic cytotoxic JJ cord-299038-e0nsol3y 222 24 T t NN cord-299038-e0nsol3y 222 25 cell cell NN cord-299038-e0nsol3y 222 26 responses response NNS cord-299038-e0nsol3y 222 27 to to TO cord-299038-e0nsol3y 222 28 inhibit inhibit VB cord-299038-e0nsol3y 222 29 intracellular intracellular JJ cord-299038-e0nsol3y 222 30 bacterial bacterial JJ cord-299038-e0nsol3y 222 31 infection infection NN cord-299038-e0nsol3y 223 1 ( ( -LRB- cord-299038-e0nsol3y 223 2 Ding Ding NNP cord-299038-e0nsol3y 223 3 et et FW cord-299038-e0nsol3y 223 4 al al NNP cord-299038-e0nsol3y 223 5 . . . cord-299038-e0nsol3y 223 6 2016 2016 CD cord-299038-e0nsol3y 223 7 ) ) -RRB- cord-299038-e0nsol3y 223 8 . . . cord-299038-e0nsol3y 224 1 One one CD cord-299038-e0nsol3y 224 2 line line NN cord-299038-e0nsol3y 224 3 of of IN cord-299038-e0nsol3y 224 4 evidence evidence NN cord-299038-e0nsol3y 224 5 developed develop VBN cord-299038-e0nsol3y 224 6 in in IN cord-299038-e0nsol3y 224 7 recent recent JJ cord-299038-e0nsol3y 224 8 years year NNS cord-299038-e0nsol3y 224 9 suggests suggest VBZ cord-299038-e0nsol3y 224 10 a a DT cord-299038-e0nsol3y 224 11 potential potential NN cord-299038-e0nsol3y 224 12 for for IN cord-299038-e0nsol3y 224 13 direct direct JJ cord-299038-e0nsol3y 224 14 interactions interaction NNS cord-299038-e0nsol3y 224 15 between between IN cord-299038-e0nsol3y 224 16 Siglec Siglec NNP cord-299038-e0nsol3y 224 17 receptors receptor NNS cord-299038-e0nsol3y 224 18 , , , cord-299038-e0nsol3y 224 19 e.g. e.g. IN cord-299038-e0nsol3y 224 20 human human JJ cord-299038-e0nsol3y 224 21 Siglec-5 Siglec-5 NNPS cord-299038-e0nsol3y 224 22 or or CC cord-299038-e0nsol3y 224 23 -9 -9 NN cord-299038-e0nsol3y 224 24 and and CC cord-299038-e0nsol3y 224 25 murine murine JJ cord-299038-e0nsol3y 224 26 Siglec Siglec NNP cord-299038-e0nsol3y 224 27 - - HYPH cord-299038-e0nsol3y 224 28 E E NNP cord-299038-e0nsol3y 224 29 and and CC cord-299038-e0nsol3y 224 30 -F -f ADD cord-299038-e0nsol3y 224 31 , , , cord-299038-e0nsol3y 224 32 and and CC cord-299038-e0nsol3y 224 33 various various JJ cord-299038-e0nsol3y 224 34 toll toll NN cord-299038-e0nsol3y 224 35 - - HYPH cord-299038-e0nsol3y 224 36 like like JJ cord-299038-e0nsol3y 224 37 receptors receptor NNS cord-299038-e0nsol3y 224 38 ( ( -LRB- cord-299038-e0nsol3y 224 39 TLRs TLRs NNP cord-299038-e0nsol3y 224 40 ) ) -RRB- cord-299038-e0nsol3y 224 41 to to TO cord-299038-e0nsol3y 224 42 downregulate downregulate VB cord-299038-e0nsol3y 224 43 the the DT cord-299038-e0nsol3y 224 44 inflammatory inflammatory JJ cord-299038-e0nsol3y 224 45 pathways pathway NNS cord-299038-e0nsol3y 224 46 downstream downstream RB cord-299038-e0nsol3y 224 47 of of IN cord-299038-e0nsol3y 224 48 their -PRON- PRP$ cord-299038-e0nsol3y 224 49 pattern pattern NN cord-299038-e0nsol3y 224 50 recognition recognition NN cord-299038-e0nsol3y 225 1 ( ( -LRB- cord-299038-e0nsol3y 225 2 Chen Chen NNP cord-299038-e0nsol3y 225 3 et et NNP cord-299038-e0nsol3y 225 4 al al NNP cord-299038-e0nsol3y 225 5 . . NNP cord-299038-e0nsol3y 225 6 2014a 2014a CD cord-299038-e0nsol3y 225 7 ) ) -RRB- cord-299038-e0nsol3y 225 8 . . . cord-299038-e0nsol3y 226 1 Consequently consequently RB cord-299038-e0nsol3y 226 2 , , , cord-299038-e0nsol3y 226 3 Siglec Siglec NNP cord-299038-e0nsol3y 226 4 - - HYPH cord-299038-e0nsol3y 226 5 E e NN cord-299038-e0nsol3y 226 6 deletion deletion NN cord-299038-e0nsol3y 226 7 was be VBD cord-299038-e0nsol3y 226 8 seen see VBN cord-299038-e0nsol3y 226 9 to to TO cord-299038-e0nsol3y 226 10 boost boost VB cord-299038-e0nsol3y 226 11 DC DC NNP cord-299038-e0nsol3y 226 12 responses response NNS cord-299038-e0nsol3y 226 13 to to IN cord-299038-e0nsol3y 226 14 a a DT cord-299038-e0nsol3y 226 15 broad broad JJ cord-299038-e0nsol3y 226 16 range range NN cord-299038-e0nsol3y 226 17 of of IN cord-299038-e0nsol3y 226 18 microbial microbial JJ cord-299038-e0nsol3y 226 19 TLR TLR NNP cord-299038-e0nsol3y 226 20 ligands ligand NNS cord-299038-e0nsol3y 226 21 . . . cord-299038-e0nsol3y 227 1 In in IN cord-299038-e0nsol3y 227 2 this this DT cord-299038-e0nsol3y 227 3 model model NN cord-299038-e0nsol3y 227 4 , , , cord-299038-e0nsol3y 227 5 activation activation NN cord-299038-e0nsol3y 227 6 of of IN cord-299038-e0nsol3y 227 7 the the DT cord-299038-e0nsol3y 227 8 mammalian mammalian JJ cord-299038-e0nsol3y 227 9 sialidase sialidase NN cord-299038-e0nsol3y 227 10 Neu1 Neu1 NNP cord-299038-e0nsol3y 227 11 to to IN cord-299038-e0nsol3y 227 12 the the DT cord-299038-e0nsol3y 227 13 cell cell NN cord-299038-e0nsol3y 227 14 surface surface NN cord-299038-e0nsol3y 227 15 disrupts disrupt VBZ cord-299038-e0nsol3y 227 16 Siglec Siglec NNP cord-299038-e0nsol3y 227 17 - - HYPH cord-299038-e0nsol3y 227 18 E E NNP cord-299038-e0nsol3y 227 19 - - HYPH cord-299038-e0nsol3y 227 20 TLR4 tlr4 JJ cord-299038-e0nsol3y 227 21 interaction interaction NN cord-299038-e0nsol3y 227 22 , , , cord-299038-e0nsol3y 227 23 suggesting suggest VBG cord-299038-e0nsol3y 227 24 it -PRON- PRP cord-299038-e0nsol3y 227 25 can can MD cord-299038-e0nsol3y 227 26 serve serve VB cord-299038-e0nsol3y 227 27 to to TO cord-299038-e0nsol3y 227 28 derepress derepress VB cord-299038-e0nsol3y 227 29 and and CC cord-299038-e0nsol3y 227 30 allow allow VB cord-299038-e0nsol3y 227 31 positive positive JJ cord-299038-e0nsol3y 227 32 feedback feedback NN cord-299038-e0nsol3y 227 33 of of IN cord-299038-e0nsol3y 227 34 TLR TLR NNP cord-299038-e0nsol3y 227 35 activation activation NN cord-299038-e0nsol3y 227 36 during during IN cord-299038-e0nsol3y 227 37 infection infection NN cord-299038-e0nsol3y 228 1 ( ( -LRB- cord-299038-e0nsol3y 228 2 Chen Chen NNP cord-299038-e0nsol3y 228 3 et et NNP cord-299038-e0nsol3y 228 4 al al NNP cord-299038-e0nsol3y 228 5 . . NNP cord-299038-e0nsol3y 228 6 2014a 2014a CD cord-299038-e0nsol3y 228 7 ) ) -RRB- cord-299038-e0nsol3y 228 8 . . . cord-299038-e0nsol3y 229 1 Caution caution NN cord-299038-e0nsol3y 229 2 is be VBZ cord-299038-e0nsol3y 229 3 warranted warrant VBN cord-299038-e0nsol3y 229 4 , , , cord-299038-e0nsol3y 229 5 however however RB cord-299038-e0nsol3y 229 6 , , , cord-299038-e0nsol3y 229 7 by by IN cord-299038-e0nsol3y 229 8 another another DT cord-299038-e0nsol3y 229 9 study study NN cord-299038-e0nsol3y 229 10 applied apply VBD cord-299038-e0nsol3y 229 11 quantitative quantitative JJ cord-299038-e0nsol3y 229 12 proteomics proteomic NNS cord-299038-e0nsol3y 229 13 to to IN cord-299038-e0nsol3y 229 14 three three CD cord-299038-e0nsol3y 229 15 different different JJ cord-299038-e0nsol3y 229 16 strains strain NNS cord-299038-e0nsol3y 229 17 of of IN cord-299038-e0nsol3y 229 18 Siglec Siglec NNP cord-299038-e0nsol3y 229 19 - - HYPH cord-299038-e0nsol3y 229 20 E e NN cord-299038-e0nsol3y 229 21 - - JJ cord-299038-e0nsol3y 229 22 deficient deficient JJ cord-299038-e0nsol3y 229 23 mice mouse NNS cord-299038-e0nsol3y 229 24 . . . cord-299038-e0nsol3y 230 1 Quantitative quantitative JJ cord-299038-e0nsol3y 230 2 proteomics proteomic NNS cord-299038-e0nsol3y 230 3 found find VBD cord-299038-e0nsol3y 230 4 no no DT cord-299038-e0nsol3y 230 5 consistent consistent JJ cord-299038-e0nsol3y 230 6 differences difference NNS cord-299038-e0nsol3y 230 7 in in IN cord-299038-e0nsol3y 230 8 TLR4 TLR4 NNP cord-299038-e0nsol3y 230 9 signaling signal VBG cord-299038-e0nsol3y 230 10 or or CC cord-299038-e0nsol3y 230 11 TLR4 tlr4 CD cord-299038-e0nsol3y 230 12 endocytosis endocytosis NN cord-299038-e0nsol3y 230 13 in in IN cord-299038-e0nsol3y 230 14 response response NN cord-299038-e0nsol3y 230 15 to to IN cord-299038-e0nsol3y 230 16 LPS LPS NNP cord-299038-e0nsol3y 230 17 , , , cord-299038-e0nsol3y 230 18 nor nor CC cord-299038-e0nsol3y 230 19 did do VBD cord-299038-e0nsol3y 230 20 macrophages macrophage NNS cord-299038-e0nsol3y 230 21 from from IN cord-299038-e0nsol3y 230 22 the the DT cord-299038-e0nsol3y 230 23 Siglec Siglec NNP cord-299038-e0nsol3y 230 24 - - HYPH cord-299038-e0nsol3y 230 25 E e NN cord-299038-e0nsol3y 230 26 - - JJ cord-299038-e0nsol3y 230 27 deficient deficient JJ cord-299038-e0nsol3y 230 28 mice mouse NNS cord-299038-e0nsol3y 230 29 exhibit exhibit VBP cord-299038-e0nsol3y 230 30 significant significant JJ cord-299038-e0nsol3y 230 31 differences difference NNS cord-299038-e0nsol3y 230 32 in in IN cord-299038-e0nsol3y 230 33 uptake uptake NN cord-299038-e0nsol3y 230 34 or or CC cord-299038-e0nsol3y 230 35 killing killing NN cord-299038-e0nsol3y 230 36 of of IN cord-299038-e0nsol3y 230 37 Salmonella Salmonella NNP cord-299038-e0nsol3y 230 38 enterica enterica NN cord-299038-e0nsol3y 230 39 in in IN cord-299038-e0nsol3y 230 40 vitro vitro FW cord-299038-e0nsol3y 230 41 ( ( -LRB- cord-299038-e0nsol3y 230 42 Nagala Nagala NNP cord-299038-e0nsol3y 230 43 et et FW cord-299038-e0nsol3y 230 44 al al NNP cord-299038-e0nsol3y 230 45 . . . cord-299038-e0nsol3y 230 46 2017 2017 CD cord-299038-e0nsol3y 230 47 ) ) -RRB- cord-299038-e0nsol3y 230 48 . . . cord-299038-e0nsol3y 231 1 Siglecs Siglecs NNP cord-299038-e0nsol3y 231 2 are be VBP cord-299038-e0nsol3y 232 1 important important JJ cord-299038-e0nsol3y 232 2 and and CC cord-299038-e0nsol3y 232 3 broadly broadly RB cord-299038-e0nsol3y 232 4 distributed distribute VBN cord-299038-e0nsol3y 232 5 lectin lectin NN cord-299038-e0nsol3y 232 6 receptors receptor NNS cord-299038-e0nsol3y 232 7 of of IN cord-299038-e0nsol3y 232 8 leukocytes leukocyte NNS cord-299038-e0nsol3y 232 9 uniquely uniquely RB cord-299038-e0nsol3y 232 10 poised poise VBN cord-299038-e0nsol3y 232 11 to to TO cord-299038-e0nsol3y 232 12 detect detect VB cord-299038-e0nsol3y 232 13 Sias Sias NNP cord-299038-e0nsol3y 232 14 and and CC cord-299038-e0nsol3y 232 15 its -PRON- PRP$ cord-299038-e0nsol3y 232 16 perturbation perturbation NN cord-299038-e0nsol3y 232 17 during during IN cord-299038-e0nsol3y 232 18 homeostasis homeostasis NN cord-299038-e0nsol3y 232 19 and and CC cord-299038-e0nsol3y 232 20 in in IN cord-299038-e0nsol3y 232 21 disease disease NN cord-299038-e0nsol3y 232 22 states state NNS cord-299038-e0nsol3y 232 23 . . . cord-299038-e0nsol3y 233 1 The the DT cord-299038-e0nsol3y 233 2 importance importance NN cord-299038-e0nsol3y 233 3 of of IN cord-299038-e0nsol3y 233 4 Siglecs Siglecs NNP cord-299038-e0nsol3y 233 5 in in IN cord-299038-e0nsol3y 233 6 immunopathology immunopathology NN cord-299038-e0nsol3y 233 7 was be VBD cord-299038-e0nsol3y 233 8 proposed propose VBN cord-299038-e0nsol3y 233 9 as as RB cord-299038-e0nsol3y 233 10 early early RB cord-299038-e0nsol3y 233 11 as as IN cord-299038-e0nsol3y 233 12 the the DT cord-299038-e0nsol3y 233 13 identification identification NN cord-299038-e0nsol3y 233 14 of of IN cord-299038-e0nsol3y 233 15 Siglec-3 Siglec-3 NNP cord-299038-e0nsol3y 233 16 ( ( -LRB- cord-299038-e0nsol3y 233 17 CD33 CD33 NNP cord-299038-e0nsol3y 233 18 ) ) -RRB- cord-299038-e0nsol3y 233 19 and and CC cord-299038-e0nsol3y 233 20 Siglec-2 Siglec-2 NNP cord-299038-e0nsol3y 233 21 ( ( -LRB- cord-299038-e0nsol3y 233 22 CD22 CD22 NNP cord-299038-e0nsol3y 233 23 ) ) -RRB- cord-299038-e0nsol3y 233 24 as as IN cord-299038-e0nsol3y 233 25 biological biological JJ cord-299038-e0nsol3y 233 26 markers marker NNS cord-299038-e0nsol3y 233 27 of of IN cord-299038-e0nsol3y 233 28 myeloid myeloid NN cord-299038-e0nsol3y 233 29 leukemias leukemia NNS cord-299038-e0nsol3y 233 30 and and CC cord-299038-e0nsol3y 233 31 B b NN cord-299038-e0nsol3y 233 32 cell cell NN cord-299038-e0nsol3y 233 33 lymphomas lymphoma NNS cord-299038-e0nsol3y 233 34 , , , cord-299038-e0nsol3y 233 35 respectively respectively RB cord-299038-e0nsol3y 233 36 . . . cord-299038-e0nsol3y 234 1 Mounting mount VBG cord-299038-e0nsol3y 234 2 evidence evidence NN cord-299038-e0nsol3y 234 3 supports support VBZ cord-299038-e0nsol3y 234 4 the the DT cord-299038-e0nsol3y 234 5 concept concept NN cord-299038-e0nsol3y 234 6 that that IN cord-299038-e0nsol3y 234 7 Sia Sia NNP cord-299038-e0nsol3y 234 8 molecular molecular JJ cord-299038-e0nsol3y 234 9 mimicry mimicry NN cord-299038-e0nsol3y 234 10 serves serve VBZ cord-299038-e0nsol3y 234 11 as as IN cord-299038-e0nsol3y 234 12 a a DT cord-299038-e0nsol3y 234 13 virulence virulence NN cord-299038-e0nsol3y 234 14 mechanism mechanism NN cord-299038-e0nsol3y 234 15 to to TO cord-299038-e0nsol3y 234 16 subvert subvert VB cord-299038-e0nsol3y 234 17 host host NN cord-299038-e0nsol3y 234 18 innate innate JJ cord-299038-e0nsol3y 234 19 immunity immunity NN cord-299038-e0nsol3y 234 20 or or CC cord-299038-e0nsol3y 234 21 to to TO cord-299038-e0nsol3y 234 22 infect infect VB cord-299038-e0nsol3y 234 23 permissive permissive JJ cord-299038-e0nsol3y 234 24 target target NN cord-299038-e0nsol3y 234 25 cells cell NNS cord-299038-e0nsol3y 234 26 through through IN cord-299038-e0nsol3y 234 27 an an DT cord-299038-e0nsol3y 234 28 interplay interplay NN cord-299038-e0nsol3y 234 29 with with IN cord-299038-e0nsol3y 234 30 various various JJ cord-299038-e0nsol3y 234 31 Siglecs Siglecs NNP cord-299038-e0nsol3y 234 32 . . . cord-299038-e0nsol3y 235 1 As as IN cord-299038-e0nsol3y 235 2 our -PRON- PRP$ cord-299038-e0nsol3y 235 3 understanding understanding NN cord-299038-e0nsol3y 235 4 of of IN cord-299038-e0nsol3y 235 5 Siglec Siglec NNP cord-299038-e0nsol3y 235 6 influences influence NNS cord-299038-e0nsol3y 235 7 on on IN cord-299038-e0nsol3y 235 8 glycans glycan NNS cord-299038-e0nsol3y 235 9 - - HYPH cord-299038-e0nsol3y 235 10 mediated mediate VBN cord-299038-e0nsol3y 235 11 host host NN cord-299038-e0nsol3y 235 12 - - HYPH cord-299038-e0nsol3y 235 13 pathogen pathogen NN cord-299038-e0nsol3y 235 14 interactions interaction NNS cord-299038-e0nsol3y 235 15 is be VBZ cord-299038-e0nsol3y 235 16 now now RB cord-299038-e0nsol3y 235 17 rapidly rapidly RB cord-299038-e0nsol3y 235 18 expanding expand VBG cord-299038-e0nsol3y 235 19 and and CC cord-299038-e0nsol3y 235 20 deepening deepen VBG cord-299038-e0nsol3y 235 21 , , , cord-299038-e0nsol3y 235 22 there there EX cord-299038-e0nsol3y 235 23 is be VBZ cord-299038-e0nsol3y 235 24 considerable considerable JJ cord-299038-e0nsol3y 235 25 interest interest NN cord-299038-e0nsol3y 235 26 in in IN cord-299038-e0nsol3y 235 27 exploiting exploit VBG cord-299038-e0nsol3y 235 28 Siglecs Siglecs NNP cord-299038-e0nsol3y 235 29 for for IN cord-299038-e0nsol3y 235 30 immunotherapy immunotherapy NN cord-299038-e0nsol3y 235 31 and and CC cord-299038-e0nsol3y 235 32 disease disease NN cord-299038-e0nsol3y 235 33 prevention prevention NN cord-299038-e0nsol3y 235 34 . . . cord-299038-e0nsol3y 236 1 Design design NN cord-299038-e0nsol3y 236 2 of of IN cord-299038-e0nsol3y 236 3 glycan glycan NN cord-299038-e0nsol3y 236 4 - - HYPH cord-299038-e0nsol3y 236 5 based base VBN cord-299038-e0nsol3y 236 6 therapeutics therapeutic NNS cord-299038-e0nsol3y 236 7 and and CC cord-299038-e0nsol3y 236 8 their -PRON- PRP$ cord-299038-e0nsol3y 236 9 requirements requirement NNS cord-299038-e0nsol3y 236 10 for for IN cord-299038-e0nsol3y 236 11 potency potency NN cord-299038-e0nsol3y 236 12 and and CC cord-299038-e0nsol3y 236 13 specificity specificity NN cord-299038-e0nsol3y 236 14 will will MD cord-299038-e0nsol3y 236 15 likely likely RB cord-299038-e0nsol3y 236 16 provide provide VB cord-299038-e0nsol3y 236 17 a a DT cord-299038-e0nsol3y 236 18 new new JJ cord-299038-e0nsol3y 236 19 biotechnological biotechnological JJ cord-299038-e0nsol3y 236 20 approach approach NN cord-299038-e0nsol3y 236 21 to to TO cord-299038-e0nsol3y 236 22 effectively effectively RB cord-299038-e0nsol3y 236 23 intervene intervene VB cord-299038-e0nsol3y 236 24 in in IN cord-299038-e0nsol3y 236 25 immunological immunological JJ cord-299038-e0nsol3y 236 26 processes process NNS cord-299038-e0nsol3y 236 27 to to TO cord-299038-e0nsol3y 236 28 reduce reduce VB cord-299038-e0nsol3y 236 29 the the DT cord-299038-e0nsol3y 236 30 incidence incidence NN cord-299038-e0nsol3y 236 31 and and CC cord-299038-e0nsol3y 236 32 severity severity NN cord-299038-e0nsol3y 236 33 infectious infectious JJ cord-299038-e0nsol3y 236 34 diseases disease NNS cord-299038-e0nsol3y 236 35 . . . cord-299038-e0nsol3y 237 1 Virus virus NN cord-299038-e0nsol3y 237 2 particle particle NN cord-299038-e0nsol3y 237 3 release release NN cord-299038-e0nsol3y 237 4 from from IN cord-299038-e0nsol3y 237 5 glycosphingolipid glycosphingolipid NN cord-299038-e0nsol3y 237 6 - - HYPH cord-299038-e0nsol3y 237 7 enriched enrich VBN cord-299038-e0nsol3y 237 8 microdomains microdomain NNS cord-299038-e0nsol3y 237 9 is be VBZ cord-299038-e0nsol3y 237 10 essential essential JJ cord-299038-e0nsol3y 237 11 for for IN cord-299038-e0nsol3y 237 12 dendritic dendritic JJ cord-299038-e0nsol3y 237 13 cellmediated cellmediate VBN cord-299038-e0nsol3y 237 14 capture capture NN cord-299038-e0nsol3y 237 15 and and CC cord-299038-e0nsol3y 237 16 transfer transfer NN cord-299038-e0nsol3y 237 17 of of IN cord-299038-e0nsol3y 237 18 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 237 19 and and CC cord-299038-e0nsol3y 237 20 henipavirus henipavirus NNP cord-299038-e0nsol3y 237 21 Siglec-5 Siglec-5 NNPS cord-299038-e0nsol3y 238 1 and and CC cord-299038-e0nsol3y 238 2 Siglec-14 Siglec-14 NNS cord-299038-e0nsol3y 238 3 are be VBP cord-299038-e0nsol3y 238 4 polymorphic polymorphic JJ cord-299038-e0nsol3y 238 5 paired pair VBN cord-299038-e0nsol3y 238 6 receptors receptor NNS cord-299038-e0nsol3y 238 7 that that WDT cord-299038-e0nsol3y 238 8 modulate modulate VBP cord-299038-e0nsol3y 238 9 neutrophil neutrophil NN cord-299038-e0nsol3y 238 10 and and CC cord-299038-e0nsol3y 238 11 amnion amnion NN cord-299038-e0nsol3y 238 12 signaling signal VBG cord-299038-e0nsol3y 238 13 responses response NNS cord-299038-e0nsol3y 238 14 to to IN cord-299038-e0nsol3y 238 15 group group NN cord-299038-e0nsol3y 238 16 B B NNP cord-299038-e0nsol3y 238 17 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 238 18 Cloning Cloning NNP cord-299038-e0nsol3y 238 19 and and CC cord-299038-e0nsol3y 238 20 characterization characterization NN cord-299038-e0nsol3y 238 21 of of IN cord-299038-e0nsol3y 238 22 human human JJ cord-299038-e0nsol3y 238 23 Siglec-11 Siglec-11 NNS cord-299038-e0nsol3y 238 24 . . . cord-299038-e0nsol3y 239 1 A a DT cord-299038-e0nsol3y 239 2 recently recently RB cord-299038-e0nsol3y 239 3 evolved evolve VBN cord-299038-e0nsol3y 239 4 signaling signal VBG cord-299038-e0nsol3y 239 5 molecule molecule NN cord-299038-e0nsol3y 239 6 that that WDT cord-299038-e0nsol3y 239 7 can can MD cord-299038-e0nsol3y 239 8 interact interact VB cord-299038-e0nsol3y 239 9 with with IN cord-299038-e0nsol3y 239 10 SHP-1 SHP-1 NNP cord-299038-e0nsol3y 239 11 and and CC cord-299038-e0nsol3y 239 12 SHP-2 SHP-2 NNP cord-299038-e0nsol3y 239 13 and and CC cord-299038-e0nsol3y 239 14 is be VBZ cord-299038-e0nsol3y 239 15 expressed express VBN cord-299038-e0nsol3y 239 16 by by IN cord-299038-e0nsol3y 239 17 tissue tissue NN cord-299038-e0nsol3y 239 18 macrophages macrophage NNS cord-299038-e0nsol3y 239 19 , , , cord-299038-e0nsol3y 239 20 including include VBG cord-299038-e0nsol3y 239 21 brain brain NN cord-299038-e0nsol3y 239 22 microglia microglia NNP cord-299038-e0nsol3y 239 23 Discovery Discovery NNP cord-299038-e0nsol3y 239 24 of of IN cord-299038-e0nsol3y 239 25 Siglec-14 Siglec-14 NNP cord-299038-e0nsol3y 239 26 , , , cord-299038-e0nsol3y 239 27 a a DT cord-299038-e0nsol3y 239 28 novel novel JJ cord-299038-e0nsol3y 239 29 sialic sialic NN cord-299038-e0nsol3y 239 30 acid acid NN cord-299038-e0nsol3y 239 31 receptor receptor NN cord-299038-e0nsol3y 239 32 undergoing undergo VBG cord-299038-e0nsol3y 239 33 concerted concerted JJ cord-299038-e0nsol3y 239 34 evolution evolution NN cord-299038-e0nsol3y 239 35 with with IN cord-299038-e0nsol3y 239 36 Siglec-5 Siglec-5 NNS cord-299038-e0nsol3y 240 1 in in IN cord-299038-e0nsol3y 240 2 primates primate NNS cord-299038-e0nsol3y 240 3 Loss Loss NNP cord-299038-e0nsol3y 240 4 of of IN cord-299038-e0nsol3y 240 5 Siglec-14 Siglec-14 NNP cord-299038-e0nsol3y 240 6 reduces reduce VBZ cord-299038-e0nsol3y 240 7 the the DT cord-299038-e0nsol3y 240 8 risk risk NN cord-299038-e0nsol3y 240 9 of of IN cord-299038-e0nsol3y 240 10 chronic chronic JJ cord-299038-e0nsol3y 240 11 obstructive obstructive JJ cord-299038-e0nsol3y 240 12 pulmonary pulmonary JJ cord-299038-e0nsol3y 240 13 disease disease NN cord-299038-e0nsol3y 240 14 exacerbation exacerbation NN cord-299038-e0nsol3y 240 15 Glycan glycan JJ cord-299038-e0nsol3y 240 16 deletions deletion NNS cord-299038-e0nsol3y 240 17 in in IN cord-299038-e0nsol3y 240 18 the the DT cord-299038-e0nsol3y 240 19 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 240 20 gp120 gp120 NNP cord-299038-e0nsol3y 240 21 V1 V1 NNPS cord-299038-e0nsol3y 240 22 / / SYM cord-299038-e0nsol3y 240 23 V2 v2 NN cord-299038-e0nsol3y 240 24 domain domain NN cord-299038-e0nsol3y 240 25 compromise compromise NN cord-299038-e0nsol3y 240 26 viral viral JJ cord-299038-e0nsol3y 240 27 infectivity infectivity NN cord-299038-e0nsol3y 240 28 , , , cord-299038-e0nsol3y 240 29 sensitize sensitize VB cord-299038-e0nsol3y 240 30 the the DT cord-299038-e0nsol3y 240 31 mutant mutant JJ cord-299038-e0nsol3y 240 32 virus virus NN cord-299038-e0nsol3y 240 33 strains strain VBZ cord-299038-e0nsol3y 240 34 to to IN cord-299038-e0nsol3y 240 35 carbohydrate carbohydrate NN cord-299038-e0nsol3y 240 36 - - HYPH cord-299038-e0nsol3y 240 37 binding bind VBG cord-299038-e0nsol3y 240 38 agents agent NNS cord-299038-e0nsol3y 240 39 and and CC cord-299038-e0nsol3y 240 40 represent represent VB cord-299038-e0nsol3y 240 41 a a DT cord-299038-e0nsol3y 240 42 specific specific JJ cord-299038-e0nsol3y 240 43 target target NN cord-299038-e0nsol3y 240 44 for for IN cord-299038-e0nsol3y 240 45 therapeutic therapeutic JJ cord-299038-e0nsol3y 240 46 intervention intervention NN cord-299038-e0nsol3y 241 1 Sialic Sialic NNP cord-299038-e0nsol3y 241 2 acid acid NN cord-299038-e0nsol3y 241 3 - - HYPH cord-299038-e0nsol3y 241 4 binding bind VBG cord-299038-e0nsol3y 241 5 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 241 6 - - HYPH cord-299038-e0nsol3y 241 7 like like JJ cord-299038-e0nsol3y 241 8 lectin lectin NN cord-299038-e0nsol3y 241 9 7 7 CD cord-299038-e0nsol3y 241 10 mediates mediate VBZ cord-299038-e0nsol3y 241 11 selective selective JJ cord-299038-e0nsol3y 241 12 recognition recognition NN cord-299038-e0nsol3y 241 13 of of IN cord-299038-e0nsol3y 241 14 sialylated sialylated JJ cord-299038-e0nsol3y 241 15 glycans glycan NNS cord-299038-e0nsol3y 241 16 expressed express VBN cord-299038-e0nsol3y 241 17 on on IN cord-299038-e0nsol3y 241 18 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 241 19 jejuni jejuni NNP cord-299038-e0nsol3y 242 1 lipooligosaccharides lipooligosaccharides NNP cord-299038-e0nsol3y 242 2 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 242 3 jejuni jejuni NNP cord-299038-e0nsol3y 242 4 lipooligosaccharides lipooligosaccharide NNS cord-299038-e0nsol3y 242 5 modulate modulate VBP cord-299038-e0nsol3y 242 6 dendritic dendritic JJ cord-299038-e0nsol3y 242 7 cell cell NN cord-299038-e0nsol3y 242 8 - - HYPH cord-299038-e0nsol3y 242 9 mediated mediate VBN cord-299038-e0nsol3y 242 10 T t NN cord-299038-e0nsol3y 242 11 cell cell NN cord-299038-e0nsol3y 242 12 polarization polarization NN cord-299038-e0nsol3y 242 13 in in IN cord-299038-e0nsol3y 242 14 a a DT cord-299038-e0nsol3y 242 15 sialic sialic JJ cord-299038-e0nsol3y 242 16 acid acid NN cord-299038-e0nsol3y 242 17 linkage linkage NN cord-299038-e0nsol3y 242 18 - - HYPH cord-299038-e0nsol3y 242 19 dependent dependent JJ cord-299038-e0nsol3y 242 20 manner manner NN cord-299038-e0nsol3y 243 1 SIGLEC16 SIGLEC16 NNP cord-299038-e0nsol3y 243 2 encodes encode VBZ cord-299038-e0nsol3y 243 3 a a DT cord-299038-e0nsol3y 243 4 DAP12-associated dap12-associate VBN cord-299038-e0nsol3y 243 5 receptor receptor NN cord-299038-e0nsol3y 243 6 expressed express VBN cord-299038-e0nsol3y 243 7 in in IN cord-299038-e0nsol3y 243 8 macrophages macrophage NNS cord-299038-e0nsol3y 243 9 that that WDT cord-299038-e0nsol3y 243 10 evolved evolve VBD cord-299038-e0nsol3y 243 11 from from IN cord-299038-e0nsol3y 243 12 its -PRON- PRP$ cord-299038-e0nsol3y 243 13 inhibitory inhibitory JJ cord-299038-e0nsol3y 243 14 counterpart counterpart NN cord-299038-e0nsol3y 243 15 SIGLEC11 siglec11 NN cord-299038-e0nsol3y 243 16 and and CC cord-299038-e0nsol3y 243 17 has have VBZ cord-299038-e0nsol3y 243 18 functional functional JJ cord-299038-e0nsol3y 243 19 and and CC cord-299038-e0nsol3y 243 20 non non JJ cord-299038-e0nsol3y 243 21 - - JJ cord-299038-e0nsol3y 243 22 functional functional JJ cord-299038-e0nsol3y 243 23 alleles allele NNS cord-299038-e0nsol3y 243 24 in in IN cord-299038-e0nsol3y 243 25 humans human NNS cord-299038-e0nsol3y 243 26 Group Group NNP cord-299038-e0nsol3y 243 27 B B NNP cord-299038-e0nsol3y 243 28 streptococcal streptococcal JJ cord-299038-e0nsol3y 243 29 capsular capsular NN cord-299038-e0nsol3y 243 30 sialic sialic NN cord-299038-e0nsol3y 243 31 acids acid NNS cord-299038-e0nsol3y 243 32 interact interact VBP cord-299038-e0nsol3y 243 33 with with IN cord-299038-e0nsol3y 243 34 siglecs siglecs JJ cord-299038-e0nsol3y 243 35 ( ( -LRB- cord-299038-e0nsol3y 243 36 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 243 37 - - HYPH cord-299038-e0nsol3y 243 38 like like JJ cord-299038-e0nsol3y 243 39 lectins lectin NNS cord-299038-e0nsol3y 243 40 ) ) -RRB- cord-299038-e0nsol3y 243 41 on on IN cord-299038-e0nsol3y 243 42 human human JJ cord-299038-e0nsol3y 243 43 leukocytes leukocyte NNS cord-299038-e0nsol3y 243 44 Group Group NNP cord-299038-e0nsol3y 243 45 B B NNP cord-299038-e0nsol3y 243 46 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 243 47 suppression suppression NN cord-299038-e0nsol3y 243 48 of of IN cord-299038-e0nsol3y 243 49 phagocyte phagocyte NNP cord-299038-e0nsol3y 243 50 functions function NNS cord-299038-e0nsol3y 243 51 by by IN cord-299038-e0nsol3y 243 52 protein protein NN cord-299038-e0nsol3y 243 53 - - HYPH cord-299038-e0nsol3y 243 54 mediated mediate VBN cord-299038-e0nsol3y 243 55 engagement engagement NN cord-299038-e0nsol3y 243 56 of of IN cord-299038-e0nsol3y 243 57 human human JJ cord-299038-e0nsol3y 243 58 Siglec-5 Siglec-5 NNS cord-299038-e0nsol3y 244 1 Molecular molecular JJ cord-299038-e0nsol3y 244 2 mimicry mimicry NN cord-299038-e0nsol3y 244 3 of of IN cord-299038-e0nsol3y 244 4 host host NN cord-299038-e0nsol3y 244 5 sialylated sialylated JJ cord-299038-e0nsol3y 244 6 glycans glycan NNS cord-299038-e0nsol3y 244 7 allows allow VBZ cord-299038-e0nsol3y 244 8 a a DT cord-299038-e0nsol3y 244 9 bacterial bacterial JJ cord-299038-e0nsol3y 244 10 pathogen pathogen NN cord-299038-e0nsol3y 244 11 to to TO cord-299038-e0nsol3y 244 12 engage engage VB cord-299038-e0nsol3y 244 13 neutrophil neutrophil NN cord-299038-e0nsol3y 244 14 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 244 15 and and CC cord-299038-e0nsol3y 244 16 dampen dampen VB cord-299038-e0nsol3y 244 17 the the DT cord-299038-e0nsol3y 244 18 innate innate JJ cord-299038-e0nsol3y 244 19 immune immune JJ cord-299038-e0nsol3y 244 20 response response NN cord-299038-e0nsol3y 244 21 Group Group NNP cord-299038-e0nsol3y 244 22 B B NNP cord-299038-e0nsol3y 244 23 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 244 24 engages engage VBZ cord-299038-e0nsol3y 244 25 an an DT cord-299038-e0nsol3y 244 26 inhibitory inhibitory JJ cord-299038-e0nsol3y 244 27 Siglec Siglec NNP cord-299038-e0nsol3y 244 28 through through IN cord-299038-e0nsol3y 244 29 sialic sialic JJ cord-299038-e0nsol3y 244 30 acid acid NN cord-299038-e0nsol3y 244 31 mimicry mimicry NN cord-299038-e0nsol3y 244 32 to to TO cord-299038-e0nsol3y 244 33 blunt blunt VB cord-299038-e0nsol3y 244 34 innate innate JJ cord-299038-e0nsol3y 244 35 immune immune JJ cord-299038-e0nsol3y 244 36 and and CC cord-299038-e0nsol3y 244 37 inflammatory inflammatory JJ cord-299038-e0nsol3y 244 38 responses response NNS cord-299038-e0nsol3y 244 39 in in IN cord-299038-e0nsol3y 244 40 vivo vivo NN cord-299038-e0nsol3y 244 41 Role role NN cord-299038-e0nsol3y 244 42 of of IN cord-299038-e0nsol3y 244 43 macrophage macrophage NN cord-299038-e0nsol3y 244 44 sialoadhesin sialoadhesin NN cord-299038-e0nsol3y 244 45 in in IN cord-299038-e0nsol3y 244 46 host host NN cord-299038-e0nsol3y 244 47 defense defense NN cord-299038-e0nsol3y 244 48 against against IN cord-299038-e0nsol3y 244 49 the the DT cord-299038-e0nsol3y 244 50 sialylated sialylated JJ cord-299038-e0nsol3y 244 51 pathogen pathogen NN cord-299038-e0nsol3y 244 52 group group NN cord-299038-e0nsol3y 244 53 B B NNP cord-299038-e0nsol3y 244 54 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 244 55 Identification identification NN cord-299038-e0nsol3y 244 56 and and CC cord-299038-e0nsol3y 244 57 characterization characterization NN cord-299038-e0nsol3y 244 58 of of IN cord-299038-e0nsol3y 244 59 adsorbed adsorbed JJ cord-299038-e0nsol3y 244 60 serum serum NN cord-299038-e0nsol3y 244 61 sialoglycans sialoglycan NNS cord-299038-e0nsol3y 244 62 on on IN cord-299038-e0nsol3y 244 63 Leishmania Leishmania NNP cord-299038-e0nsol3y 244 64 donovani donovani NNP cord-299038-e0nsol3y 245 1 promastigotes promastigotes NNP cord-299038-e0nsol3y 246 1 Induction induction NN cord-299038-e0nsol3y 246 2 of of IN cord-299038-e0nsol3y 246 3 Siglec Siglec NNP cord-299038-e0nsol3y 246 4 - - HYPH cord-299038-e0nsol3y 246 5 G G NNP cord-299038-e0nsol3y 246 6 by by IN cord-299038-e0nsol3y 246 7 RNA RNA NNP cord-299038-e0nsol3y 246 8 viruses virus NNS cord-299038-e0nsol3y 246 9 inhibits inhibit VBZ cord-299038-e0nsol3y 246 10 the the DT cord-299038-e0nsol3y 246 11 innate innate JJ cord-299038-e0nsol3y 246 12 immune immune JJ cord-299038-e0nsol3y 246 13 response response NN cord-299038-e0nsol3y 246 14 by by IN cord-299038-e0nsol3y 246 15 promoting promote VBG cord-299038-e0nsol3y 246 16 RIG rig NN cord-299038-e0nsol3y 246 17 - - : cord-299038-e0nsol3y 246 18 I -PRON- PRP cord-299038-e0nsol3y 246 19 degradation degradation NN cord-299038-e0nsol3y 246 20 Broad broad JJ cord-299038-e0nsol3y 246 21 and and CC cord-299038-e0nsol3y 246 22 direct direct JJ cord-299038-e0nsol3y 246 23 interaction interaction NN cord-299038-e0nsol3y 246 24 between between IN cord-299038-e0nsol3y 246 25 TLR TLR NNP cord-299038-e0nsol3y 246 26 and and CC cord-299038-e0nsol3y 246 27 Siglec Siglec NNP cord-299038-e0nsol3y 246 28 families family NNS cord-299038-e0nsol3y 246 29 of of IN cord-299038-e0nsol3y 246 30 pattern pattern NN cord-299038-e0nsol3y 246 31 recognition recognition NN cord-299038-e0nsol3y 246 32 receptors receptor NNS cord-299038-e0nsol3y 246 33 and and CC cord-299038-e0nsol3y 246 34 its -PRON- PRP$ cord-299038-e0nsol3y 246 35 regulation regulation NN cord-299038-e0nsol3y 246 36 by by IN cord-299038-e0nsol3y 246 37 Neu1 Neu1 NNP cord-299038-e0nsol3y 246 38 Additive Additive NNP cord-299038-e0nsol3y 246 39 inhibition inhibition NN cord-299038-e0nsol3y 246 40 of of IN cord-299038-e0nsol3y 246 41 porcine porcine JJ cord-299038-e0nsol3y 246 42 reproductive reproductive JJ cord-299038-e0nsol3y 246 43 and and CC cord-299038-e0nsol3y 246 44 respiratory respiratory JJ cord-299038-e0nsol3y 246 45 syndrome syndrome NN cord-299038-e0nsol3y 246 46 virus virus NN cord-299038-e0nsol3y 246 47 infection infection NN cord-299038-e0nsol3y 246 48 with with IN cord-299038-e0nsol3y 246 49 the the DT cord-299038-e0nsol3y 246 50 soluble soluble JJ cord-299038-e0nsol3y 246 51 sialoadhesin sialoadhesin NN cord-299038-e0nsol3y 246 52 and and CC cord-299038-e0nsol3y 246 53 CD163 CD163 NNP cord-299038-e0nsol3y 246 54 receptors receptor NNS cord-299038-e0nsol3y 246 55 Structural structural JJ cord-299038-e0nsol3y 246 56 and and CC cord-299038-e0nsol3y 246 57 genetic genetic JJ cord-299038-e0nsol3y 246 58 diversity diversity NN cord-299038-e0nsol3y 246 59 of of IN cord-299038-e0nsol3y 246 60 group group NN cord-299038-e0nsol3y 246 61 B b NN cord-299038-e0nsol3y 246 62 streptococcus streptococcus NN cord-299038-e0nsol3y 246 63 capsular capsular NN cord-299038-e0nsol3y 246 64 polysaccharides polysaccharide NNS cord-299038-e0nsol3y 246 65 Mouse Mouse NNP cord-299038-e0nsol3y 246 66 macrophage macrophage NN cord-299038-e0nsol3y 246 67 hemagglutinin hemagglutinin NN cord-299038-e0nsol3y 246 68 ( ( -LRB- cord-299038-e0nsol3y 246 69 sheep sheep NN cord-299038-e0nsol3y 246 70 erythrocyte erythrocyte NN cord-299038-e0nsol3y 246 71 receptor receptor NN cord-299038-e0nsol3y 246 72 ) ) -RRB- cord-299038-e0nsol3y 246 73 with with IN cord-299038-e0nsol3y 246 74 specificity specificity NN cord-299038-e0nsol3y 246 75 for for IN cord-299038-e0nsol3y 246 76 sialylated sialylated JJ cord-299038-e0nsol3y 246 77 glycoconjugates glycoconjugate NNS cord-299038-e0nsol3y 246 78 characterized characterize VBN cord-299038-e0nsol3y 246 79 by by IN cord-299038-e0nsol3y 246 80 a a DT cord-299038-e0nsol3y 246 81 monoclonal monoclonal JJ cord-299038-e0nsol3y 246 82 antibody antibody NN cord-299038-e0nsol3y 246 83 Sialoadhesin Sialoadhesin NNP cord-299038-e0nsol3y 246 84 , , , cord-299038-e0nsol3y 246 85 a a DT cord-299038-e0nsol3y 246 86 macrophage macrophage NN cord-299038-e0nsol3y 246 87 sialic sialic NN cord-299038-e0nsol3y 246 88 acid acid NN cord-299038-e0nsol3y 246 89 binding bind VBG cord-299038-e0nsol3y 246 90 receptor receptor NN cord-299038-e0nsol3y 246 91 for for IN cord-299038-e0nsol3y 246 92 haemopoietic haemopoietic JJ cord-299038-e0nsol3y 246 93 cells cell NNS cord-299038-e0nsol3y 246 94 with with IN cord-299038-e0nsol3y 246 95 17 17 CD cord-299038-e0nsol3y 246 96 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 246 97 - - HYPH cord-299038-e0nsol3y 246 98 like like JJ cord-299038-e0nsol3y 246 99 domains domain NNS cord-299038-e0nsol3y 246 100 Siglecs Siglecs NNP cord-299038-e0nsol3y 246 101 and and CC cord-299038-e0nsol3y 246 102 their -PRON- PRP$ cord-299038-e0nsol3y 246 103 roles role NNS cord-299038-e0nsol3y 246 104 in in IN cord-299038-e0nsol3y 246 105 the the DT cord-299038-e0nsol3y 246 106 immune immune JJ cord-299038-e0nsol3y 246 107 system system NN cord-299038-e0nsol3y 247 1 Bacteria Bacteria NNS cord-299038-e0nsol3y 247 2 - - HYPH cord-299038-e0nsol3y 247 3 phagocyte phagocyte NN cord-299038-e0nsol3y 247 4 interactions interaction NNS cord-299038-e0nsol3y 247 5 : : : cord-299038-e0nsol3y 248 1 emerging emerge VBG cord-299038-e0nsol3y 248 2 tactics tactic NNS cord-299038-e0nsol3y 248 3 in in IN cord-299038-e0nsol3y 248 4 an an DT cord-299038-e0nsol3y 248 5 ancient ancient JJ cord-299038-e0nsol3y 248 6 rivalry rivalry NN cord-299038-e0nsol3y 248 7 Hyaluronate Hyaluronate NNP cord-299038-e0nsol3y 248 8 capsule capsule NN cord-299038-e0nsol3y 248 9 and and CC cord-299038-e0nsol3y 248 10 surface surface VB cord-299038-e0nsol3y 248 11 M M NNP cord-299038-e0nsol3y 248 12 protein protein NN cord-299038-e0nsol3y 248 13 in in IN cord-299038-e0nsol3y 248 14 resistance resistance NN cord-299038-e0nsol3y 248 15 to to IN cord-299038-e0nsol3y 248 16 opsonization opsonization NN cord-299038-e0nsol3y 248 17 of of IN cord-299038-e0nsol3y 248 18 group group NN cord-299038-e0nsol3y 248 19 A a DT cord-299038-e0nsol3y 248 20 streptococci streptococcus NNS cord-299038-e0nsol3y 248 21 Interaction Interaction NNP cord-299038-e0nsol3y 248 22 of of IN cord-299038-e0nsol3y 248 23 the the DT cord-299038-e0nsol3y 248 24 European european JJ cord-299038-e0nsol3y 248 25 genotype genotype NN cord-299038-e0nsol3y 248 26 porcine porcine JJ cord-299038-e0nsol3y 248 27 reproductive reproductive JJ cord-299038-e0nsol3y 248 28 and and CC cord-299038-e0nsol3y 248 29 respiratory respiratory JJ cord-299038-e0nsol3y 248 30 syndrome syndrome NN cord-299038-e0nsol3y 248 31 virus virus NN cord-299038-e0nsol3y 248 32 ( ( -LRB- cord-299038-e0nsol3y 248 33 PRRSV PRRSV NNP cord-299038-e0nsol3y 248 34 ) ) -RRB- cord-299038-e0nsol3y 248 35 with with IN cord-299038-e0nsol3y 248 36 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 248 37 ( ( -LRB- cord-299038-e0nsol3y 248 38 CD169 CD169 NNP cord-299038-e0nsol3y 248 39 / / SYM cord-299038-e0nsol3y 248 40 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 248 41 ) ) -RRB- cord-299038-e0nsol3y 248 42 inhibits inhibit VBZ cord-299038-e0nsol3y 249 1 alveolar alveolar JJ cord-299038-e0nsol3y 249 2 macrophage macrophage NN cord-299038-e0nsol3y 249 3 phagocytosis phagocytosis NN cord-299038-e0nsol3y 249 4 Microbial microbial JJ cord-299038-e0nsol3y 249 5 glycosaminoglycan glycosaminoglycan JJ cord-299038-e0nsol3y 249 6 glycosyltransferases glycosyltransferase NNS cord-299038-e0nsol3y 249 7 Porcine porcine JJ cord-299038-e0nsol3y 249 8 arterivirus arterivirus NN cord-299038-e0nsol3y 249 9 infection infection NN cord-299038-e0nsol3y 249 10 of of IN cord-299038-e0nsol3y 249 11 alveolar alveolar JJ cord-299038-e0nsol3y 249 12 macrophages macrophage NNS cord-299038-e0nsol3y 249 13 is be VBZ cord-299038-e0nsol3y 249 14 mediated mediate VBN cord-299038-e0nsol3y 249 15 by by IN cord-299038-e0nsol3y 249 16 sialic sialic JJ cord-299038-e0nsol3y 249 17 acid acid NN cord-299038-e0nsol3y 249 18 on on IN cord-299038-e0nsol3y 249 19 the the DT cord-299038-e0nsol3y 249 20 virus virus NN cord-299038-e0nsol3y 249 21 Porcine porcine JJ cord-299038-e0nsol3y 249 22 arterivirus arterivirus NN cord-299038-e0nsol3y 249 23 attachment attachment NN cord-299038-e0nsol3y 249 24 to to IN cord-299038-e0nsol3y 249 25 the the DT cord-299038-e0nsol3y 249 26 macrophage macrophage NN cord-299038-e0nsol3y 249 27 - - HYPH cord-299038-e0nsol3y 249 28 specific specific JJ cord-299038-e0nsol3y 249 29 receptor receptor NN cord-299038-e0nsol3y 249 30 sialoadhesin sialoadhesin NN cord-299038-e0nsol3y 249 31 is be VBZ cord-299038-e0nsol3y 249 32 dependent dependent JJ cord-299038-e0nsol3y 249 33 on on IN cord-299038-e0nsol3y 249 34 the the DT cord-299038-e0nsol3y 249 35 sialic sialic JJ cord-299038-e0nsol3y 249 36 acid acid NN cord-299038-e0nsol3y 249 37 - - HYPH cord-299038-e0nsol3y 249 38 binding bind VBG cord-299038-e0nsol3y 249 39 activity activity NN cord-299038-e0nsol3y 249 40 of of IN cord-299038-e0nsol3y 249 41 the the DT cord-299038-e0nsol3y 249 42 N n CD cord-299038-e0nsol3y 249 43 - - HYPH cord-299038-e0nsol3y 249 44 terminal terminal JJ cord-299038-e0nsol3y 249 45 immunoglobulin immunoglobulin NN cord-299038-e0nsol3y 249 46 domain domain NN cord-299038-e0nsol3y 249 47 of of IN cord-299038-e0nsol3y 249 48 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 249 49 -9)-alpha -9)-alpha : cord-299038-e0nsol3y 249 50 - - HYPH cord-299038-e0nsol3y 249 51 N N NNP cord-299038-e0nsol3y 249 52 - - HYPH cord-299038-e0nsol3y 249 53 acetylneuraminic acetylneuraminic NNP cord-299038-e0nsol3y 249 54 acid acid NN cord-299038-e0nsol3y 249 55 ] ] -RRB- cord-299038-e0nsol3y 249 56 are be VBP cord-299038-e0nsol3y 249 57 elicited elicit VBN cord-299038-e0nsol3y 249 58 by by IN cord-299038-e0nsol3y 249 59 immunization immunization NN cord-299038-e0nsol3y 249 60 of of IN cord-299038-e0nsol3y 249 61 mice mouse NNS cord-299038-e0nsol3y 249 62 with with IN cord-299038-e0nsol3y 249 63 Escherichia Escherichia NNP cord-299038-e0nsol3y 249 64 coli coli NNS cord-299038-e0nsol3y 249 65 K92 K92 NNP cord-299038-e0nsol3y 249 66 conjugates conjugate NNS cord-299038-e0nsol3y 249 67 : : : cord-299038-e0nsol3y 249 68 potential potential JJ cord-299038-e0nsol3y 249 69 vaccines vaccine NNS cord-299038-e0nsol3y 249 70 for for IN cord-299038-e0nsol3y 249 71 groups group NNS cord-299038-e0nsol3y 249 72 B b NN cord-299038-e0nsol3y 249 73 and and CC cord-299038-e0nsol3y 249 74 C C NNP cord-299038-e0nsol3y 249 75 meningococci meningococci NNS cord-299038-e0nsol3y 249 76 and and CC cord-299038-e0nsol3y 249 77 E. E. NNP cord-299038-e0nsol3y 249 78 coli coli NNS cord-299038-e0nsol3y 250 1 K1 K1 NNP cord-299038-e0nsol3y 251 1 The the DT cord-299038-e0nsol3y 251 2 lectin lectin NN cord-299038-e0nsol3y 252 1 Siglec Siglec NNP cord-299038-e0nsol3y 252 2 - - HYPH cord-299038-e0nsol3y 252 3 G G NNP cord-299038-e0nsol3y 252 4 inhibits inhibit VBZ cord-299038-e0nsol3y 252 5 dendritic dendritic JJ cord-299038-e0nsol3y 252 6 cell cell NN cord-299038-e0nsol3y 252 7 cross cross NN cord-299038-e0nsol3y 252 8 - - NN cord-299038-e0nsol3y 252 9 presentation presentation NN cord-299038-e0nsol3y 252 10 by by IN cord-299038-e0nsol3y 252 11 impairing impair VBG cord-299038-e0nsol3y 252 12 MHC MHC NNP cord-299038-e0nsol3y 252 13 class class NN cord-299038-e0nsol3y 252 14 I i NN cord-299038-e0nsol3y 252 15 - - HYPH cord-299038-e0nsol3y 252 16 peptide peptide NN cord-299038-e0nsol3y 252 17 complex complex JJ cord-299038-e0nsol3y 252 18 formation formation NN cord-299038-e0nsol3y 252 19 Effects effect NNS cord-299038-e0nsol3y 252 20 of of IN cord-299038-e0nsol3y 252 21 origin origin NN cord-299038-e0nsol3y 252 22 and and CC cord-299038-e0nsol3y 252 23 state state NN cord-299038-e0nsol3y 252 24 of of IN cord-299038-e0nsol3y 252 25 differentiation differentiation NN cord-299038-e0nsol3y 252 26 and and CC cord-299038-e0nsol3y 252 27 activation activation NN cord-299038-e0nsol3y 252 28 of of IN cord-299038-e0nsol3y 252 29 monocytes monocyte NNS cord-299038-e0nsol3y 252 30 / / SYM cord-299038-e0nsol3y 252 31 macrophages macrophage NNS cord-299038-e0nsol3y 252 32 on on IN cord-299038-e0nsol3y 252 33 their -PRON- PRP$ cord-299038-e0nsol3y 252 34 susceptibility susceptibility NN cord-299038-e0nsol3y 252 35 to to IN cord-299038-e0nsol3y 252 36 porcine porcine JJ cord-299038-e0nsol3y 252 37 reproductive reproductive JJ cord-299038-e0nsol3y 252 38 and and CC cord-299038-e0nsol3y 252 39 respiratory respiratory JJ cord-299038-e0nsol3y 252 40 syndrome syndrome NN cord-299038-e0nsol3y 252 41 virus virus NN cord-299038-e0nsol3y 252 42 ( ( -LRB- cord-299038-e0nsol3y 252 43 PRRSV PRRSV NNP cord-299038-e0nsol3y 252 44 ) ) -RRB- cord-299038-e0nsol3y 252 45 Identification identification NN cord-299038-e0nsol3y 252 46 of of IN cord-299038-e0nsol3y 252 47 a a DT cord-299038-e0nsol3y 252 48 putative putative JJ cord-299038-e0nsol3y 252 49 receptor receptor NN cord-299038-e0nsol3y 252 50 for for IN cord-299038-e0nsol3y 252 51 porcine porcine JJ cord-299038-e0nsol3y 252 52 reproductive reproductive JJ cord-299038-e0nsol3y 252 53 and and CC cord-299038-e0nsol3y 252 54 respiratory respiratory JJ cord-299038-e0nsol3y 252 55 syndrome syndrome NN cord-299038-e0nsol3y 252 56 virus virus NN cord-299038-e0nsol3y 252 57 on on IN cord-299038-e0nsol3y 252 58 porcine porcine JJ cord-299038-e0nsol3y 252 59 alveolar alveolar NN cord-299038-e0nsol3y 252 60 macrophages macrophage NNS cord-299038-e0nsol3y 253 1 Sialylated sialylated JJ cord-299038-e0nsol3y 253 2 ligands ligand NNS cord-299038-e0nsol3y 253 3 on on IN cord-299038-e0nsol3y 253 4 pathogenic pathogenic JJ cord-299038-e0nsol3y 253 5 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 253 6 cruzi cruzi NNP cord-299038-e0nsol3y 253 7 interact interact VB cord-299038-e0nsol3y 253 8 with with IN cord-299038-e0nsol3y 253 9 Siglec Siglec NNP cord-299038-e0nsol3y 253 10 - - HYPH cord-299038-e0nsol3y 253 11 E E NNP cord-299038-e0nsol3y 253 12 ( ( -LRB- cord-299038-e0nsol3y 254 1 sialic sialic JJ cord-299038-e0nsol3y 254 2 acid acid NN cord-299038-e0nsol3y 254 3 - - HYPH cord-299038-e0nsol3y 254 4 binding bind VBG cord-299038-e0nsol3y 254 5 Ig Ig NNP cord-299038-e0nsol3y 254 6 - - HYPH cord-299038-e0nsol3y 254 7 like like JJ cord-299038-e0nsol3y 254 8 lectin lectin NN cord-299038-e0nsol3y 254 9 - - HYPH cord-299038-e0nsol3y 254 10 E e NN cord-299038-e0nsol3y 254 11 ) ) -RRB- cord-299038-e0nsol3y 254 12 Mouse Mouse NNP cord-299038-e0nsol3y 254 13 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 254 14 mediates mediate VBZ cord-299038-e0nsol3y 254 15 trans trans NN cord-299038-e0nsol3y 254 16 - - NN cord-299038-e0nsol3y 254 17 infection infection NN cord-299038-e0nsol3y 254 18 of of IN cord-299038-e0nsol3y 254 19 surface surface NN cord-299038-e0nsol3y 254 20 - - HYPH cord-299038-e0nsol3y 254 21 bound bind VBN cord-299038-e0nsol3y 254 22 murine murine JJ cord-299038-e0nsol3y 254 23 leukemia leukemia NN cord-299038-e0nsol3y 254 24 virus virus NN cord-299038-e0nsol3y 254 25 in in IN cord-299038-e0nsol3y 254 26 a a DT cord-299038-e0nsol3y 254 27 sialic sialic JJ cord-299038-e0nsol3y 254 28 acid acid NN cord-299038-e0nsol3y 254 29 N N NNP cord-299038-e0nsol3y 254 30 - - HYPH cord-299038-e0nsol3y 254 31 Acyl Acyl NNP cord-299038-e0nsol3y 254 32 side side NN cord-299038-e0nsol3y 254 33 chain chain NN cord-299038-e0nsol3y 254 34 - - HYPH cord-299038-e0nsol3y 254 35 dependent dependent JJ cord-299038-e0nsol3y 254 36 manner manner NN cord-299038-e0nsol3y 254 37 Occurrence occurrence NN cord-299038-e0nsol3y 254 38 of of IN cord-299038-e0nsol3y 254 39 unique unique JJ cord-299038-e0nsol3y 254 40 polysialosyl polysialosyl JJ cord-299038-e0nsol3y 254 41 carbohydrate carbohydrate NN cord-299038-e0nsol3y 254 42 units unit NNS cord-299038-e0nsol3y 254 43 in in IN cord-299038-e0nsol3y 254 44 glycoproteins glycoprotein NNS cord-299038-e0nsol3y 254 45 of of IN cord-299038-e0nsol3y 254 46 developing develop VBG cord-299038-e0nsol3y 254 47 brain brain NN cord-299038-e0nsol3y 254 48 Studies study NNS cord-299038-e0nsol3y 254 49 on on IN cord-299038-e0nsol3y 254 50 the the DT cord-299038-e0nsol3y 254 51 pathogenicity pathogenicity NN cord-299038-e0nsol3y 254 52 of of IN cord-299038-e0nsol3y 254 53 group group NN cord-299038-e0nsol3y 254 54 A a DT cord-299038-e0nsol3y 254 55 streptococci streptococcus NNS cord-299038-e0nsol3y 254 56 . . . cord-299038-e0nsol3y 255 1 II II NNP cord-299038-e0nsol3y 255 2 . . . cord-299038-e0nsol3y 256 1 The the DT cord-299038-e0nsol3y 256 2 antiphagocytic antiphagocytic JJ cord-299038-e0nsol3y 256 3 effects effect NNS cord-299038-e0nsol3y 256 4 of of IN cord-299038-e0nsol3y 256 5 the the DT cord-299038-e0nsol3y 256 6 M M NNP cord-299038-e0nsol3y 256 7 protein protein NN cord-299038-e0nsol3y 256 8 and and CC cord-299038-e0nsol3y 256 9 the the DT cord-299038-e0nsol3y 256 10 capsular capsular NN cord-299038-e0nsol3y 256 11 gel gel NN cord-299038-e0nsol3y 256 12 Replication replication NN cord-299038-e0nsol3y 256 13 characteristics characteristic NNS cord-299038-e0nsol3y 256 14 of of IN cord-299038-e0nsol3y 256 15 eight eight CD cord-299038-e0nsol3y 256 16 virulent virulent JJ cord-299038-e0nsol3y 256 17 and and CC cord-299038-e0nsol3y 256 18 two two CD cord-299038-e0nsol3y 256 19 attenuated attenuated JJ cord-299038-e0nsol3y 256 20 genotype genotype NN cord-299038-e0nsol3y 256 21 1 1 CD cord-299038-e0nsol3y 256 22 and and CC cord-299038-e0nsol3y 256 23 2 2 CD cord-299038-e0nsol3y 256 24 porcine porcine JJ cord-299038-e0nsol3y 256 25 reproductive reproductive JJ cord-299038-e0nsol3y 256 26 and and CC cord-299038-e0nsol3y 256 27 respiratory respiratory JJ cord-299038-e0nsol3y 256 28 syndrome syndrome NN cord-299038-e0nsol3y 256 29 virus virus NN cord-299038-e0nsol3y 256 30 ( ( -LRB- cord-299038-e0nsol3y 256 31 PRRSV PRRSV NNP cord-299038-e0nsol3y 256 32 ) ) -RRB- cord-299038-e0nsol3y 256 33 strains strain NNS cord-299038-e0nsol3y 256 34 in in IN cord-299038-e0nsol3y 256 35 nasal nasal JJ cord-299038-e0nsol3y 256 36 mucosa mucosa JJ cord-299038-e0nsol3y 256 37 explants explant NNS cord-299038-e0nsol3y 257 1 A a DT cord-299038-e0nsol3y 257 2 human human JJ cord-299038-e0nsol3y 257 3 - - HYPH cord-299038-e0nsol3y 257 4 specific specific JJ cord-299038-e0nsol3y 257 5 gene gene NN cord-299038-e0nsol3y 257 6 in in IN cord-299038-e0nsol3y 257 7 microglia microglia JJ cord-299038-e0nsol3y 257 8 Perinatal perinatal JJ cord-299038-e0nsol3y 257 9 group group NN cord-299038-e0nsol3y 257 10 B B NNP cord-299038-e0nsol3y 257 11 streptococcal streptococcal JJ cord-299038-e0nsol3y 257 12 disease disease NN cord-299038-e0nsol3y 257 13 Characterization characterization NN cord-299038-e0nsol3y 257 14 of of IN cord-299038-e0nsol3y 257 15 the the DT cord-299038-e0nsol3y 257 16 specific specific JJ cord-299038-e0nsol3y 257 17 interaction interaction NN cord-299038-e0nsol3y 257 18 between between IN cord-299038-e0nsol3y 257 19 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 257 20 and and CC cord-299038-e0nsol3y 257 21 sialylated sialylated JJ cord-299038-e0nsol3y 257 22 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 257 23 jejuni jejuni NNP cord-299038-e0nsol3y 258 1 lipooligosaccharides lipooligosaccharides NNP cord-299038-e0nsol3y 258 2 Siglec-7 Siglec-7 NNP cord-299038-e0nsol3y 259 1 specifically specifically RB cord-299038-e0nsol3y 259 2 recognizes recognize VBZ cord-299038-e0nsol3y 259 3 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 259 4 jejuni jejuni NNP cord-299038-e0nsol3y 259 5 strains strain NNS cord-299038-e0nsol3y 259 6 associated associate VBN cord-299038-e0nsol3y 259 7 with with IN cord-299038-e0nsol3y 259 8 oculomotor oculomotor NN cord-299038-e0nsol3y 259 9 weakness weakness NN cord-299038-e0nsol3y 259 10 in in IN cord-299038-e0nsol3y 259 11 Guillain Guillain NNP cord-299038-e0nsol3y 259 12 - - HYPH cord-299038-e0nsol3y 259 13 Barre Barre NNP cord-299038-e0nsol3y 259 14 syndrome syndrome NN cord-299038-e0nsol3y 259 15 and and CC cord-299038-e0nsol3y 259 16 Miller Miller NNP cord-299038-e0nsol3y 259 17 Fisher Fisher NNP cord-299038-e0nsol3y 259 18 syndrome syndrome NN cord-299038-e0nsol3y 259 19 Sialylation Sialylation NNP cord-299038-e0nsol3y 259 20 of of IN cord-299038-e0nsol3y 259 21 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 259 22 jejuni jejuni NNP cord-299038-e0nsol3y 259 23 lipo lipo NN cord-299038-e0nsol3y 259 24 - - HYPH cord-299038-e0nsol3y 259 25 oligosaccharides oligosaccharide NNS cord-299038-e0nsol3y 259 26 : : : cord-299038-e0nsol3y 259 27 impact impact NN cord-299038-e0nsol3y 259 28 on on IN cord-299038-e0nsol3y 259 29 phagocytosis phagocytosis NN cord-299038-e0nsol3y 259 30 and and CC cord-299038-e0nsol3y 259 31 cytokine cytokine NN cord-299038-e0nsol3y 259 32 production production NN cord-299038-e0nsol3y 259 33 in in IN cord-299038-e0nsol3y 259 34 mice mouse NNS cord-299038-e0nsol3y 259 35 Sialylation Sialylation NNP cord-299038-e0nsol3y 259 36 of of IN cord-299038-e0nsol3y 259 37 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 259 38 jejuni jejuni NNP cord-299038-e0nsol3y 260 1 endotoxin endotoxin NN cord-299038-e0nsol3y 260 2 promotes promote VBZ cord-299038-e0nsol3y 260 3 dendritic dendritic JJ cord-299038-e0nsol3y 260 4 cell cell NN cord-299038-e0nsol3y 260 5 - - HYPH cord-299038-e0nsol3y 260 6 mediated mediate VBN cord-299038-e0nsol3y 260 7 B b NN cord-299038-e0nsol3y 260 8 cell cell NN cord-299038-e0nsol3y 260 9 responses response NNS cord-299038-e0nsol3y 260 10 through through IN cord-299038-e0nsol3y 260 11 CD14-dependent cd14-dependent CD cord-299038-e0nsol3y 260 12 production production NN cord-299038-e0nsol3y 260 13 of of IN cord-299038-e0nsol3y 260 14 IFNβ IFNβ NNS cord-299038-e0nsol3y 260 15 and and CC cord-299038-e0nsol3y 260 16 TNFα TNFα NNP cord-299038-e0nsol3y 260 17 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 261 1 is be VBZ cord-299038-e0nsol3y 261 2 a a DT cord-299038-e0nsol3y 261 3 novel novel JJ cord-299038-e0nsol3y 261 4 dendritic dendritic JJ cord-299038-e0nsol3y 261 5 cell cell NN cord-299038-e0nsol3y 261 6 receptor receptor NN cord-299038-e0nsol3y 261 7 that that WDT cord-299038-e0nsol3y 261 8 mediates mediate VBZ cord-299038-e0nsol3y 261 9 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 261 10 trans trans NN cord-299038-e0nsol3y 261 11 - - NN cord-299038-e0nsol3y 261 12 infection infection NN cord-299038-e0nsol3y 261 13 through through IN cord-299038-e0nsol3y 261 14 recognition recognition NN cord-299038-e0nsol3y 261 15 of of IN cord-299038-e0nsol3y 261 16 viral viral JJ cord-299038-e0nsol3y 261 17 membrane membrane NN cord-299038-e0nsol3y 261 18 gangliosides ganglioside NNS cord-299038-e0nsol3y 262 1 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 262 2 jejuni jejuni NNP cord-299038-e0nsol3y 262 3 infections infection NNS cord-299038-e0nsol3y 262 4 and and CC cord-299038-e0nsol3y 262 5 anti anti JJ cord-299038-e0nsol3y 262 6 - - JJ cord-299038-e0nsol3y 262 7 GM1 gm1 JJ cord-299038-e0nsol3y 262 8 antibodies antibody NNS cord-299038-e0nsol3y 262 9 in in IN cord-299038-e0nsol3y 263 1 Guillain Guillain NNP cord-299038-e0nsol3y 263 2 - - HYPH cord-299038-e0nsol3y 263 3 Barre Barre NNP cord-299038-e0nsol3y 263 4 syndrome syndrome NN cord-299038-e0nsol3y 263 5 A A NNP cord-299038-e0nsol3y 263 6 systems system NNS cord-299038-e0nsol3y 263 7 genomics genomic NNS cord-299038-e0nsol3y 263 8 approach approach NN cord-299038-e0nsol3y 263 9 identifies identify VBZ cord-299038-e0nsol3y 263 10 SIGLEC15 SIGLEC15 NNP cord-299038-e0nsol3y 263 11 as as IN cord-299038-e0nsol3y 263 12 a a DT cord-299038-e0nsol3y 263 13 susceptibility susceptibility NN cord-299038-e0nsol3y 263 14 factor factor NN cord-299038-e0nsol3y 263 15 in in IN cord-299038-e0nsol3y 263 16 recurrent recurrent JJ cord-299038-e0nsol3y 263 17 vulvovaginal vulvovaginal JJ cord-299038-e0nsol3y 263 18 candidiasis candidiasis NN cord-299038-e0nsol3y 263 19 Capsules Capsules NNPS cord-299038-e0nsol3y 263 20 of of IN cord-299038-e0nsol3y 263 21 Escherichia Escherichia NNP cord-299038-e0nsol3y 263 22 coli coli NNS cord-299038-e0nsol3y 263 23 , , , cord-299038-e0nsol3y 263 24 expression expression NN cord-299038-e0nsol3y 263 25 and and CC cord-299038-e0nsol3y 263 26 biological biological JJ cord-299038-e0nsol3y 263 27 significance significance NN cord-299038-e0nsol3y 264 1 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 264 2 inhibits inhibit VBZ cord-299038-e0nsol3y 265 1 RSV RSV NNP cord-299038-e0nsol3y 265 2 - - HYPH cord-299038-e0nsol3y 265 3 induced induce VBN cord-299038-e0nsol3y 265 4 interferon interferon NN cord-299038-e0nsol3y 265 5 gamma gamma NN cord-299038-e0nsol3y 265 6 production production NN cord-299038-e0nsol3y 265 7 by by IN cord-299038-e0nsol3y 265 8 adult adult NN cord-299038-e0nsol3y 265 9 T T NNP cord-299038-e0nsol3y 265 10 cells cell NNS cord-299038-e0nsol3y 265 11 in in IN cord-299038-e0nsol3y 265 12 contrast contrast NN cord-299038-e0nsol3y 265 13 to to IN cord-299038-e0nsol3y 265 14 newborn newborn JJ cord-299038-e0nsol3y 265 15 T t NN cord-299038-e0nsol3y 265 16 cells cell NNS cord-299038-e0nsol3y 265 17 Recognition Recognition NNP cord-299038-e0nsol3y 265 18 of of IN cord-299038-e0nsol3y 265 19 sialylated sialylated JJ cord-299038-e0nsol3y 265 20 meningococcal meningococcal JJ cord-299038-e0nsol3y 265 21 lipopolysaccharide lipopolysaccharide NN cord-299038-e0nsol3y 265 22 by by IN cord-299038-e0nsol3y 265 23 siglecs siglecs NNP cord-299038-e0nsol3y 265 24 expressed express VBN cord-299038-e0nsol3y 265 25 on on IN cord-299038-e0nsol3y 265 26 myeloid myeloid JJ cord-299038-e0nsol3y 265 27 cells cell NNS cord-299038-e0nsol3y 265 28 leads lead VBZ cord-299038-e0nsol3y 265 29 to to IN cord-299038-e0nsol3y 265 30 enhanced enhanced JJ cord-299038-e0nsol3y 265 31 bacterial bacterial JJ cord-299038-e0nsol3y 265 32 uptake uptake NN cord-299038-e0nsol3y 265 33 Combined combine VBN cord-299038-e0nsol3y 265 34 bacteria bacteria NNS cord-299038-e0nsol3y 265 35 microarray microarray NN cord-299038-e0nsol3y 265 36 and and CC cord-299038-e0nsol3y 265 37 quartz quartz NNP cord-299038-e0nsol3y 265 38 crystal crystal NNP cord-299038-e0nsol3y 265 39 microbalance microbalance NN cord-299038-e0nsol3y 265 40 approach approach NN cord-299038-e0nsol3y 265 41 for for IN cord-299038-e0nsol3y 265 42 exploring explore VBG cord-299038-e0nsol3y 265 43 glycosignatures glycosignature NNS cord-299038-e0nsol3y 265 44 of of IN cord-299038-e0nsol3y 265 45 nontypeable nontypeable JJ cord-299038-e0nsol3y 265 46 Haemophilus Haemophilus NNP cord-299038-e0nsol3y 265 47 influenzae influenzae NN cord-299038-e0nsol3y 265 48 and and CC cord-299038-e0nsol3y 265 49 recognition recognition NN cord-299038-e0nsol3y 265 50 by by IN cord-299038-e0nsol3y 265 51 host host NN cord-299038-e0nsol3y 265 52 lectins lectin NNS cord-299038-e0nsol3y 265 53 Pathogenic pathogenic JJ cord-299038-e0nsol3y 265 54 Escherichia Escherichia NNP cord-299038-e0nsol3y 265 55 coli coli NNS cord-299038-e0nsol3y 265 56 Sialic Sialic NNP cord-299038-e0nsol3y 265 57 acids acid NNS cord-299038-e0nsol3y 265 58 acquired acquire VBN cord-299038-e0nsol3y 265 59 by by IN cord-299038-e0nsol3y 265 60 Pseudomonas Pseudomonas NNP cord-299038-e0nsol3y 265 61 aeruginosa aeruginosa NN cord-299038-e0nsol3y 265 62 are be VBP cord-299038-e0nsol3y 265 63 involved involve VBN cord-299038-e0nsol3y 265 64 in in IN cord-299038-e0nsol3y 265 65 reduced reduce VBN cord-299038-e0nsol3y 265 66 complement complement NN cord-299038-e0nsol3y 265 67 deposition deposition NN cord-299038-e0nsol3y 265 68 and and CC cord-299038-e0nsol3y 265 69 siglec siglec NNP cord-299038-e0nsol3y 265 70 mediated mediate VBD cord-299038-e0nsol3y 265 71 host host NN cord-299038-e0nsol3y 265 72 - - HYPH cord-299038-e0nsol3y 265 73 cell cell NN cord-299038-e0nsol3y 265 74 recognition recognition NN cord-299038-e0nsol3y 265 75 Sialoglycoproteins sialoglycoprotein NNS cord-299038-e0nsol3y 265 76 adsorbed adsorb VBN cord-299038-e0nsol3y 265 77 by by IN cord-299038-e0nsol3y 265 78 Pseudomonas Pseudomonas NNP cord-299038-e0nsol3y 265 79 aeruginosa aeruginosa NN cord-299038-e0nsol3y 266 1 facilitate facilitate VB cord-299038-e0nsol3y 266 2 their -PRON- PRP$ cord-299038-e0nsol3y 266 3 survival survival NN cord-299038-e0nsol3y 266 4 by by IN cord-299038-e0nsol3y 266 5 impeding impede VBG cord-299038-e0nsol3y 266 6 neutrophil neutrophil NN cord-299038-e0nsol3y 266 7 extracellular extracellular JJ cord-299038-e0nsol3y 266 8 trap trap NN cord-299038-e0nsol3y 266 9 through through IN cord-299038-e0nsol3y 266 10 siglec-9 siglec-9 NN cord-299038-e0nsol3y 266 11 Sialoadhesin Sialoadhesin NNP cord-299038-e0nsol3y 266 12 in in IN cord-299038-e0nsol3y 266 13 recognition recognition NN cord-299038-e0nsol3y 266 14 of of IN cord-299038-e0nsol3y 266 15 self self NN cord-299038-e0nsol3y 266 16 and and CC cord-299038-e0nsol3y 266 17 non non JJ cord-299038-e0nsol3y 266 18 - - JJ cord-299038-e0nsol3y 266 19 self self JJ cord-299038-e0nsol3y 266 20 TLR4-mediated tlr4-mediated JJ cord-299038-e0nsol3y 266 21 sensing sensing NN cord-299038-e0nsol3y 266 22 of of IN cord-299038-e0nsol3y 266 23 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 266 24 jejuni jejuni NNP cord-299038-e0nsol3y 266 25 by by IN cord-299038-e0nsol3y 266 26 dendritic dendritic JJ cord-299038-e0nsol3y 266 27 cells cell NNS cord-299038-e0nsol3y 266 28 is be VBZ cord-299038-e0nsol3y 266 29 determined determine VBN cord-299038-e0nsol3y 266 30 by by IN cord-299038-e0nsol3y 266 31 sialylation sialylation NN cord-299038-e0nsol3y 266 32 Sialic Sialic NNP cord-299038-e0nsol3y 266 33 acid acid NN cord-299038-e0nsol3y 266 34 involved involve VBN cord-299038-e0nsol3y 266 35 in in IN cord-299038-e0nsol3y 266 36 hypermucoviscosity hypermucoviscosity NN cord-299038-e0nsol3y 266 37 phenotype phenotype NN cord-299038-e0nsol3y 266 38 of of IN cord-299038-e0nsol3y 266 39 Klebsiella Klebsiella NNP cord-299038-e0nsol3y 266 40 pneumoniae pneumoniae NN cord-299038-e0nsol3y 266 41 and and CC cord-299038-e0nsol3y 266 42 associated associate VBN cord-299038-e0nsol3y 266 43 with with IN cord-299038-e0nsol3y 266 44 resistance resistance NN cord-299038-e0nsol3y 266 45 to to IN cord-299038-e0nsol3y 266 46 neutrophil neutrophil NN cord-299038-e0nsol3y 266 47 phagocytosis phagocytosis NN cord-299038-e0nsol3y 266 48 Role role NN cord-299038-e0nsol3y 266 49 of of IN cord-299038-e0nsol3y 266 50 glycosaminoglycans glycosaminoglycan NNS cord-299038-e0nsol3y 266 51 in in IN cord-299038-e0nsol3y 266 52 cellular cellular JJ cord-299038-e0nsol3y 266 53 communication communication NN cord-299038-e0nsol3y 266 54 Identification identification NN cord-299038-e0nsol3y 266 55 of of IN cord-299038-e0nsol3y 266 56 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 267 1 null null JJ cord-299038-e0nsol3y 267 2 individuals individual NNS cord-299038-e0nsol3y 267 3 infected infect VBN cord-299038-e0nsol3y 267 4 with with IN cord-299038-e0nsol3y 267 5 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 267 6 Increased Increased NNP cord-299038-e0nsol3y 267 7 association association NN cord-299038-e0nsol3y 267 8 of of IN cord-299038-e0nsol3y 267 9 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 267 10 cruzi cruzi NNP cord-299038-e0nsol3y 267 11 with with IN cord-299038-e0nsol3y 267 12 sialoadhesin sialoadhesin JJ cord-299038-e0nsol3y 267 13 positive positive JJ cord-299038-e0nsol3y 267 14 mice mice NN cord-299038-e0nsol3y 267 15 macrophages macrophage NNS cord-299038-e0nsol3y 268 1 Expression expression NN cord-299038-e0nsol3y 268 2 of of IN cord-299038-e0nsol3y 268 3 Siglec Siglec NNP cord-299038-e0nsol3y 268 4 - - HYPH cord-299038-e0nsol3y 268 5 E E NNP cord-299038-e0nsol3y 268 6 alters alter VBZ cord-299038-e0nsol3y 268 7 the the DT cord-299038-e0nsol3y 268 8 proteome proteome NN cord-299038-e0nsol3y 268 9 of of IN cord-299038-e0nsol3y 268 10 lipopolysaccharide lipopolysaccharide NN cord-299038-e0nsol3y 268 11 ( ( -LRB- cord-299038-e0nsol3y 268 12 LPS)-activated lps)-activate VBN cord-299038-e0nsol3y 268 13 macrophages macrophage NNS cord-299038-e0nsol3y 268 14 but but CC cord-299038-e0nsol3y 268 15 does do VBZ cord-299038-e0nsol3y 268 16 not not RB cord-299038-e0nsol3y 268 17 affect affect VB cord-299038-e0nsol3y 268 18 LPS LPS NNP cord-299038-e0nsol3y 268 19 - - HYPH cord-299038-e0nsol3y 268 20 driven drive VBN cord-299038-e0nsol3y 268 21 cytokine cytokine NN cord-299038-e0nsol3y 268 22 production production NN cord-299038-e0nsol3y 268 23 or or CC cord-299038-e0nsol3y 268 24 toll toll NN cord-299038-e0nsol3y 268 25 - - HYPH cord-299038-e0nsol3y 268 26 like like JJ cord-299038-e0nsol3y 269 1 receptor receptor NN cord-299038-e0nsol3y 269 2 4 4 CD cord-299038-e0nsol3y 269 3 endocytosis endocytosis NN cord-299038-e0nsol3y 270 1 A a DT cord-299038-e0nsol3y 270 2 developmentally developmentally RB cord-299038-e0nsol3y 270 3 regulated regulated JJ cord-299038-e0nsol3y 270 4 neuraminidase neuraminidase NN cord-299038-e0nsol3y 270 5 activity activity NN cord-299038-e0nsol3y 270 6 in in IN cord-299038-e0nsol3y 270 7 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 270 8 cruzi cruzi NNP cord-299038-e0nsol3y 270 9 Lectin Lectin NNP cord-299038-e0nsol3y 270 10 receptors receptor NNS cord-299038-e0nsol3y 270 11 as as IN cord-299038-e0nsol3y 270 12 markers marker NNS cord-299038-e0nsol3y 270 13 for for IN cord-299038-e0nsol3y 270 14 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 270 15 cruzi cruzi NNP cord-299038-e0nsol3y 270 16 . . . cord-299038-e0nsol3y 271 1 Developmental developmental JJ cord-299038-e0nsol3y 271 2 stages stage NNS cord-299038-e0nsol3y 271 3 and and CC cord-299038-e0nsol3y 271 4 a a DT cord-299038-e0nsol3y 271 5 study study NN cord-299038-e0nsol3y 271 6 of of IN cord-299038-e0nsol3y 271 7 the the DT cord-299038-e0nsol3y 271 8 interaction interaction NN cord-299038-e0nsol3y 271 9 of of IN cord-299038-e0nsol3y 271 10 wheat wheat NN cord-299038-e0nsol3y 271 11 germ germ NN cord-299038-e0nsol3y 271 12 agglutinin agglutinin NNS cord-299038-e0nsol3y 271 13 with with IN cord-299038-e0nsol3y 271 14 sialic sialic JJ cord-299038-e0nsol3y 271 15 acid acid NN cord-299038-e0nsol3y 271 16 residues residue NNS cord-299038-e0nsol3y 271 17 on on IN cord-299038-e0nsol3y 271 18 epimastigote epimastigote NN cord-299038-e0nsol3y 271 19 cells cell NNS cord-299038-e0nsol3y 272 1 Mucin mucin NN cord-299038-e0nsol3y 272 2 - - HYPH cord-299038-e0nsol3y 272 3 like like JJ cord-299038-e0nsol3y 272 4 molecules molecule NNS cord-299038-e0nsol3y 272 5 form form VBP cord-299038-e0nsol3y 272 6 a a DT cord-299038-e0nsol3y 272 7 negatively negatively RB cord-299038-e0nsol3y 272 8 charged charge VBN cord-299038-e0nsol3y 272 9 coat coat NN cord-299038-e0nsol3y 272 10 that that WDT cord-299038-e0nsol3y 272 11 protects protect VBZ cord-299038-e0nsol3y 272 12 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 272 13 cruzi cruzi NNP cord-299038-e0nsol3y 272 14 trypomastigotes trypomastigotes NNP cord-299038-e0nsol3y 272 15 from from IN cord-299038-e0nsol3y 272 16 killing kill VBG cord-299038-e0nsol3y 272 17 by by IN cord-299038-e0nsol3y 272 18 human human JJ cord-299038-e0nsol3y 272 19 anti anti JJ cord-299038-e0nsol3y 272 20 - - JJ cord-299038-e0nsol3y 272 21 alphagalactosyl alphagalactosyl JJ cord-299038-e0nsol3y 272 22 antibodies antibody NNS cord-299038-e0nsol3y 272 23 Dendritic dendritic JJ cord-299038-e0nsol3y 272 24 cells cell NNS cord-299038-e0nsol3y 272 25 from from IN cord-299038-e0nsol3y 272 26 the the DT cord-299038-e0nsol3y 272 27 cervical cervical JJ cord-299038-e0nsol3y 272 28 mucosa mucosa JJ cord-299038-e0nsol3y 272 29 capture capture NN cord-299038-e0nsol3y 272 30 and and CC cord-299038-e0nsol3y 272 31 transfer transfer VB cord-299038-e0nsol3y 272 32 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 272 33 via via IN cord-299038-e0nsol3y 273 1 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 273 2 Anti Anti NNP cord-299038-e0nsol3y 273 3 - - NNP cord-299038-e0nsol3y 273 4 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 273 5 antibodies antibody NNS cord-299038-e0nsol3y 273 6 block block VBP cord-299038-e0nsol3y 273 7 Ebola Ebola NNP cord-299038-e0nsol3y 273 8 viral viral JJ cord-299038-e0nsol3y 273 9 uptake uptake NN cord-299038-e0nsol3y 273 10 and and CC cord-299038-e0nsol3y 273 11 decrease decrease VB cord-299038-e0nsol3y 273 12 cytoplasmic cytoplasmic JJ cord-299038-e0nsol3y 273 13 viral viral JJ cord-299038-e0nsol3y 273 14 entry entry NN cord-299038-e0nsol3y 274 1 An an DT cord-299038-e0nsol3y 274 2 intact intact JJ cord-299038-e0nsol3y 274 3 sialoadhesin sialoadhesin NN cord-299038-e0nsol3y 274 4 ( ( -LRB- cord-299038-e0nsol3y 274 5 Sn Sn NNP cord-299038-e0nsol3y 274 6 / / SYM cord-299038-e0nsol3y 274 7 SIGLEC1 siglec1 NN cord-299038-e0nsol3y 274 8 / / SYM cord-299038-e0nsol3y 274 9 CD169 CD169 NNP cord-299038-e0nsol3y 274 10 ) ) -RRB- cord-299038-e0nsol3y 274 11 is be VBZ cord-299038-e0nsol3y 274 12 not not RB cord-299038-e0nsol3y 274 13 required require VBN cord-299038-e0nsol3y 274 14 for for IN cord-299038-e0nsol3y 274 15 attachment attachment NN cord-299038-e0nsol3y 274 16 / / SYM cord-299038-e0nsol3y 274 17 internalization internalization NN cord-299038-e0nsol3y 274 18 of of IN cord-299038-e0nsol3y 274 19 the the DT cord-299038-e0nsol3y 274 20 porcine porcine JJ cord-299038-e0nsol3y 274 21 reproductive reproductive JJ cord-299038-e0nsol3y 274 22 and and CC cord-299038-e0nsol3y 274 23 respiratory respiratory JJ cord-299038-e0nsol3y 274 24 syndrome syndrome NN cord-299038-e0nsol3y 274 25 virus virus NN cord-299038-e0nsol3y 275 1 Interferon interferon NN cord-299038-e0nsol3y 275 2 - - HYPH cord-299038-e0nsol3y 275 3 inducible inducible JJ cord-299038-e0nsol3y 275 4 mechanism mechanism NN cord-299038-e0nsol3y 275 5 of of IN cord-299038-e0nsol3y 275 6 dendritic dendritic JJ cord-299038-e0nsol3y 275 7 cell cell NN cord-299038-e0nsol3y 275 8 - - HYPH cord-299038-e0nsol3y 275 9 mediated mediate VBN cord-299038-e0nsol3y 275 10 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 275 11 dissemination dissemination NN cord-299038-e0nsol3y 275 12 is be VBZ cord-299038-e0nsol3y 275 13 dependent dependent JJ cord-299038-e0nsol3y 275 14 on on IN cord-299038-e0nsol3y 276 1 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 276 2 / / SYM cord-299038-e0nsol3y 276 3 CD169 CD169 NNP cord-299038-e0nsol3y 276 4 Sialoadhesin Sialoadhesin NNP cord-299038-e0nsol3y 276 5 expressed express VBD cord-299038-e0nsol3y 276 6 on on IN cord-299038-e0nsol3y 276 7 IFN IFN NNP cord-299038-e0nsol3y 276 8 - - HYPH cord-299038-e0nsol3y 276 9 induced induce VBN cord-299038-e0nsol3y 276 10 monocytes monocyte NNS cord-299038-e0nsol3y 276 11 binds bind VBZ cord-299038-e0nsol3y 276 12 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 276 13 and and CC cord-299038-e0nsol3y 276 14 enhances enhance VBZ cord-299038-e0nsol3y 276 15 infectivity infectivity NN cord-299038-e0nsol3y 276 16 Escherichia Escherichia NNP cord-299038-e0nsol3y 276 17 coli coli VBZ cord-299038-e0nsol3y 276 18 K1 K1 NNP cord-299038-e0nsol3y 276 19 capsular capsular NN cord-299038-e0nsol3y 276 20 polysaccharide polysaccharide NN cord-299038-e0nsol3y 276 21 associated associate VBN cord-299038-e0nsol3y 276 22 with with IN cord-299038-e0nsol3y 276 23 neonatal neonatal JJ cord-299038-e0nsol3y 276 24 meningitis meningitis NN cord-299038-e0nsol3y 276 25 Leishmania Leishmania NNP cord-299038-e0nsol3y 276 26 donovani donovani NNS cord-299038-e0nsol3y 276 27 utilize utilize VBP cord-299038-e0nsol3y 276 28 sialic sialic JJ cord-299038-e0nsol3y 276 29 acids acid NNS cord-299038-e0nsol3y 276 30 for for IN cord-299038-e0nsol3y 276 31 binding binding NN cord-299038-e0nsol3y 276 32 and and CC cord-299038-e0nsol3y 276 33 phagocytosis phagocytosis NN cord-299038-e0nsol3y 276 34 in in IN cord-299038-e0nsol3y 276 35 the the DT cord-299038-e0nsol3y 276 36 macrophages macrophage NNS cord-299038-e0nsol3y 276 37 through through IN cord-299038-e0nsol3y 276 38 selective selective JJ cord-299038-e0nsol3y 276 39 utilization utilization NN cord-299038-e0nsol3y 276 40 of of IN cord-299038-e0nsol3y 276 41 siglecs siglecs JJ cord-299038-e0nsol3y 276 42 and and CC cord-299038-e0nsol3y 276 43 impair impair VB cord-299038-e0nsol3y 276 44 the the DT cord-299038-e0nsol3y 276 45 innate innate JJ cord-299038-e0nsol3y 276 46 immune immune JJ cord-299038-e0nsol3y 276 47 arm arm NN cord-299038-e0nsol3y 276 48 Polysialic Polysialic NNP cord-299038-e0nsol3y 276 49 acid acid NN cord-299038-e0nsol3y 276 50 in in IN cord-299038-e0nsol3y 276 51 the the DT cord-299038-e0nsol3y 276 52 plasticity plasticity NN cord-299038-e0nsol3y 276 53 of of IN cord-299038-e0nsol3y 276 54 the the DT cord-299038-e0nsol3y 276 55 developing develop VBG cord-299038-e0nsol3y 276 56 and and CC cord-299038-e0nsol3y 276 57 adult adult NN cord-299038-e0nsol3y 276 58 vertebrate vertebrate JJ cord-299038-e0nsol3y 276 59 nervous nervous JJ cord-299038-e0nsol3y 276 60 system system NN cord-299038-e0nsol3y 276 61 A a DT cord-299038-e0nsol3y 276 62 soluble soluble JJ cord-299038-e0nsol3y 276 63 form form NN cord-299038-e0nsol3y 276 64 of of IN cord-299038-e0nsol3y 276 65 Siglec-9 Siglec-9 NNP cord-299038-e0nsol3y 276 66 provides provide VBZ cord-299038-e0nsol3y 276 67 a a DT cord-299038-e0nsol3y 276 68 resistance resistance NN cord-299038-e0nsol3y 276 69 against against IN cord-299038-e0nsol3y 276 70 group group NN cord-299038-e0nsol3y 276 71 B B NNP cord-299038-e0nsol3y 276 72 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 276 73 ( ( -LRB- cord-299038-e0nsol3y 276 74 GBS GBS NNP cord-299038-e0nsol3y 276 75 ) ) -RRB- cord-299038-e0nsol3y 276 76 infection infection NN cord-299038-e0nsol3y 276 77 in in IN cord-299038-e0nsol3y 276 78 transgenic transgenic JJ cord-299038-e0nsol3y 276 79 mice mouse NNS cord-299038-e0nsol3y 277 1 Paired Paired NNP cord-299038-e0nsol3y 277 2 Siglec Siglec NNP cord-299038-e0nsol3y 277 3 receptors receptor NNS cord-299038-e0nsol3y 277 4 generate generate VBP cord-299038-e0nsol3y 277 5 opposite opposite JJ cord-299038-e0nsol3y 277 6 inflammatory inflammatory JJ cord-299038-e0nsol3y 277 7 responses response NNS cord-299038-e0nsol3y 277 8 to to IN cord-299038-e0nsol3y 277 9 a a DT cord-299038-e0nsol3y 277 10 human human JJ cord-299038-e0nsol3y 277 11 - - HYPH cord-299038-e0nsol3y 277 12 specific specific JJ cord-299038-e0nsol3y 277 13 pathogen pathogen NN cord-299038-e0nsol3y 277 14 Host host NN cord-299038-e0nsol3y 277 15 and and CC cord-299038-e0nsol3y 277 16 pathogen pathogen NNP cord-299038-e0nsol3y 277 17 hyaluronan hyaluronan NNP cord-299038-e0nsol3y 277 18 signal signal NN cord-299038-e0nsol3y 277 19 through through IN cord-299038-e0nsol3y 277 20 human human JJ cord-299038-e0nsol3y 277 21 siglec-9 siglec-9 NN cord-299038-e0nsol3y 277 22 to to TO cord-299038-e0nsol3y 277 23 suppress suppress VB cord-299038-e0nsol3y 277 24 neutrophil neutrophil NN cord-299038-e0nsol3y 277 25 activation activation NN cord-299038-e0nsol3y 278 1 Retroviruses retrovirus NNS cord-299038-e0nsol3y 278 2 use use VBP cord-299038-e0nsol3y 278 3 CD169-mediated cd169-mediated JJ cord-299038-e0nsol3y 278 4 trans trans NN cord-299038-e0nsol3y 278 5 - - NN cord-299038-e0nsol3y 278 6 infection infection NN cord-299038-e0nsol3y 278 7 of of IN cord-299038-e0nsol3y 278 8 permissive permissive JJ cord-299038-e0nsol3y 278 9 lymphocytes lymphocyte NNS cord-299038-e0nsol3y 278 10 to to TO cord-299038-e0nsol3y 278 11 establish establish VB cord-299038-e0nsol3y 278 12 infection infection NN cord-299038-e0nsol3y 278 13 Increasing increase VBG cord-299038-e0nsol3y 278 14 burden burden NN cord-299038-e0nsol3y 278 15 of of IN cord-299038-e0nsol3y 278 16 invasive invasive JJ cord-299038-e0nsol3y 278 17 group group NN cord-299038-e0nsol3y 278 18 B b NN cord-299038-e0nsol3y 278 19 streptococcal streptococcal JJ cord-299038-e0nsol3y 278 20 disease disease NN cord-299038-e0nsol3y 278 21 in in IN cord-299038-e0nsol3y 278 22 nonpregnant nonpregnant JJ cord-299038-e0nsol3y 278 23 adults adult NNS cord-299038-e0nsol3y 278 24 Pseudaminic Pseudaminic NNP cord-299038-e0nsol3y 278 25 acid acid NN cord-299038-e0nsol3y 278 26 on on IN cord-299038-e0nsol3y 278 27 Campylobacter Campylobacter NNP cord-299038-e0nsol3y 278 28 jejuni jejuni NNP cord-299038-e0nsol3y 278 29 flagella flagellum NNS cord-299038-e0nsol3y 279 1 modulates modulate VBZ cord-299038-e0nsol3y 279 2 dendritic dendritic JJ cord-299038-e0nsol3y 279 3 cell cell NN cord-299038-e0nsol3y 279 4 IL-10 IL-10 NNP cord-299038-e0nsol3y 279 5 expression expression NN cord-299038-e0nsol3y 279 6 via via IN cord-299038-e0nsol3y 279 7 Siglec-10 Siglec-10 NNS cord-299038-e0nsol3y 279 8 receptor receptor NN cord-299038-e0nsol3y 279 9 : : : cord-299038-e0nsol3y 279 10 a a DT cord-299038-e0nsol3y 279 11 novel novel JJ cord-299038-e0nsol3y 279 12 flagellin flagellin JJ cord-299038-e0nsol3y 279 13 - - HYPH cord-299038-e0nsol3y 279 14 host host NN cord-299038-e0nsol3y 279 15 interaction interaction NN cord-299038-e0nsol3y 279 16 Restricted restrict VBN cord-299038-e0nsol3y 279 17 complement complement NN cord-299038-e0nsol3y 279 18 activation activation NN cord-299038-e0nsol3y 279 19 by by IN cord-299038-e0nsol3y 279 20 Escherichia Escherichia NNP cord-299038-e0nsol3y 279 21 coli coli NNS cord-299038-e0nsol3y 279 22 with with IN cord-299038-e0nsol3y 279 23 the the DT cord-299038-e0nsol3y 279 24 K-1 k-1 JJ cord-299038-e0nsol3y 279 25 capsular capsular NN cord-299038-e0nsol3y 279 26 serotype serotype NN cord-299038-e0nsol3y 279 27 : : : cord-299038-e0nsol3y 279 28 a a DT cord-299038-e0nsol3y 279 29 possible possible JJ cord-299038-e0nsol3y 279 30 role role NN cord-299038-e0nsol3y 279 31 in in IN cord-299038-e0nsol3y 279 32 pathogenicity pathogenicity NN cord-299038-e0nsol3y 279 33 Bacterial bacterial JJ cord-299038-e0nsol3y 279 34 meningitis meningitis NN cord-299038-e0nsol3y 279 35 in in IN cord-299038-e0nsol3y 279 36 the the DT cord-299038-e0nsol3y 279 37 United United NNP cord-299038-e0nsol3y 279 38 States States NNP cord-299038-e0nsol3y 279 39 Role Role NNP cord-299038-e0nsol3y 279 40 of of IN cord-299038-e0nsol3y 279 41 sialic sialic JJ cord-299038-e0nsol3y 279 42 acid acid NN cord-299038-e0nsol3y 279 43 in in IN cord-299038-e0nsol3y 279 44 the the DT cord-299038-e0nsol3y 279 45 resistance resistance NN cord-299038-e0nsol3y 279 46 of of IN cord-299038-e0nsol3y 279 47 Trypanosoma Trypanosoma NNP cord-299038-e0nsol3y 279 48 cruzi cruzi NNP cord-299038-e0nsol3y 279 49 trypomastigotes trypomastigotes NNP cord-299038-e0nsol3y 279 50 to to TO cord-299038-e0nsol3y 279 51 complement complement VB cord-299038-e0nsol3y 279 52 A a DT cord-299038-e0nsol3y 279 53 protective protective JJ cord-299038-e0nsol3y 279 54 role role NN cord-299038-e0nsol3y 279 55 for for IN cord-299038-e0nsol3y 279 56 the the DT cord-299038-e0nsol3y 279 57 lectin lectin NN cord-299038-e0nsol3y 279 58 CD169 CD169 NNP cord-299038-e0nsol3y 279 59 / / SYM cord-299038-e0nsol3y 279 60 Siglec-1 Siglec-1 NNP cord-299038-e0nsol3y 279 61 against against IN cord-299038-e0nsol3y 279 62 a a DT cord-299038-e0nsol3y 279 63 pathogenic pathogenic JJ cord-299038-e0nsol3y 279 64 murine murine JJ cord-299038-e0nsol3y 279 65 retrovirus retrovirus NN cord-299038-e0nsol3y 279 66 Dual dual JJ cord-299038-e0nsol3y 279 67 actions action NNS cord-299038-e0nsol3y 279 68 of of IN cord-299038-e0nsol3y 279 69 group group NN cord-299038-e0nsol3y 279 70 B B NNP cord-299038-e0nsol3y 279 71 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 279 72 capsular capsular NN cord-299038-e0nsol3y 279 73 sialic sialic NN cord-299038-e0nsol3y 279 74 acid acid NN cord-299038-e0nsol3y 279 75 provide provide VBP cord-299038-e0nsol3y 279 76 resistance resistance NN cord-299038-e0nsol3y 279 77 to to IN cord-299038-e0nsol3y 279 78 platelet platelet NN cord-299038-e0nsol3y 279 79 - - HYPH cord-299038-e0nsol3y 279 80 mediated mediate VBN cord-299038-e0nsol3y 279 81 antimicrobial antimicrobial NN cord-299038-e0nsol3y 279 82 killing kill VBG cord-299038-e0nsol3y 279 83 The the DT cord-299038-e0nsol3y 279 84 M M NNP cord-299038-e0nsol3y 279 85 / / SYM cord-299038-e0nsol3y 279 86 GP(5 GP(5 NNP cord-299038-e0nsol3y 279 87 ) ) -RRB- cord-299038-e0nsol3y 279 88 glycoprotein glycoprotein NN cord-299038-e0nsol3y 279 89 complex complex NN cord-299038-e0nsol3y 279 90 of of IN cord-299038-e0nsol3y 279 91 porcine porcine JJ cord-299038-e0nsol3y 279 92 reproductive reproductive JJ cord-299038-e0nsol3y 279 93 and and CC cord-299038-e0nsol3y 279 94 respiratory respiratory JJ cord-299038-e0nsol3y 279 95 syndrome syndrome NN cord-299038-e0nsol3y 279 96 virus virus NN cord-299038-e0nsol3y 279 97 binds bind VBZ cord-299038-e0nsol3y 279 98 the the DT cord-299038-e0nsol3y 279 99 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 279 100 receptor receptor NN cord-299038-e0nsol3y 279 101 in in IN cord-299038-e0nsol3y 279 102 a a DT cord-299038-e0nsol3y 279 103 sialic sialic JJ cord-299038-e0nsol3y 279 104 acid acid NN cord-299038-e0nsol3y 279 105 - - HYPH cord-299038-e0nsol3y 279 106 dependent dependent JJ cord-299038-e0nsol3y 279 107 manner manner NN cord-299038-e0nsol3y 279 108 Differential differential JJ cord-299038-e0nsol3y 279 109 production production NN cord-299038-e0nsol3y 279 110 of of IN cord-299038-e0nsol3y 279 111 proinflammatory proinflammatory JJ cord-299038-e0nsol3y 279 112 cytokines cytokine NNS cord-299038-e0nsol3y 279 113 in in IN cord-299038-e0nsol3y 279 114 the the DT cord-299038-e0nsol3y 279 115 pig pig NN cord-299038-e0nsol3y 279 116 lung lung NN cord-299038-e0nsol3y 279 117 during during IN cord-299038-e0nsol3y 279 118 different different JJ cord-299038-e0nsol3y 279 119 respiratory respiratory JJ cord-299038-e0nsol3y 279 120 virus virus NN cord-299038-e0nsol3y 279 121 infections infection NNS cord-299038-e0nsol3y 279 122 : : : cord-299038-e0nsol3y 279 123 correlations correlation NNS cord-299038-e0nsol3y 279 124 with with IN cord-299038-e0nsol3y 279 125 pathogenicity pathogenicity NN cord-299038-e0nsol3y 279 126 Involvement Involvement NNP cord-299038-e0nsol3y 279 127 of of IN cord-299038-e0nsol3y 279 128 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 279 129 in in IN cord-299038-e0nsol3y 279 130 entry entry NN cord-299038-e0nsol3y 279 131 of of IN cord-299038-e0nsol3y 279 132 porcine porcine JJ cord-299038-e0nsol3y 279 133 reproductive reproductive JJ cord-299038-e0nsol3y 279 134 and and CC cord-299038-e0nsol3y 279 135 respiratory respiratory JJ cord-299038-e0nsol3y 279 136 syndrome syndrome NN cord-299038-e0nsol3y 279 137 virus virus NN cord-299038-e0nsol3y 279 138 into into IN cord-299038-e0nsol3y 279 139 porcine porcine JJ cord-299038-e0nsol3y 279 140 alveolar alveolar NN cord-299038-e0nsol3y 279 141 macrophages macrophage NNS cord-299038-e0nsol3y 280 1 Sialic Sialic NNP cord-299038-e0nsol3y 280 2 acid acid NN cord-299038-e0nsol3y 280 3 - - HYPH cord-299038-e0nsol3y 280 4 binding bind VBG cord-299038-e0nsol3y 280 5 Ig Ig NNP cord-299038-e0nsol3y 280 6 - - HYPH cord-299038-e0nsol3y 280 7 like like JJ cord-299038-e0nsol3y 280 8 lectin-7 lectin-7 NNP cord-299038-e0nsol3y 280 9 interacts interact VBZ cord-299038-e0nsol3y 280 10 with with IN cord-299038-e0nsol3y 280 11 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 280 12 gp120 gp120 NNP cord-299038-e0nsol3y 280 13 and and CC cord-299038-e0nsol3y 280 14 facilitates facilitate VBZ cord-299038-e0nsol3y 280 15 infection infection NN cord-299038-e0nsol3y 280 16 of of IN cord-299038-e0nsol3y 280 17 CD4pos cd4pos NN cord-299038-e0nsol3y 280 18 T t NN cord-299038-e0nsol3y 280 19 cells cell NNS cord-299038-e0nsol3y 280 20 and and CC cord-299038-e0nsol3y 280 21 macrophages macrophage NNS cord-299038-e0nsol3y 280 22 Biological biological JJ cord-299038-e0nsol3y 280 23 roles role NNS cord-299038-e0nsol3y 280 24 of of IN cord-299038-e0nsol3y 280 25 oligosaccharides oligosaccharide NNS cord-299038-e0nsol3y 280 26 : : : cord-299038-e0nsol3y 280 27 all all DT cord-299038-e0nsol3y 280 28 of of IN cord-299038-e0nsol3y 280 29 the the DT cord-299038-e0nsol3y 280 30 theories theory NNS cord-299038-e0nsol3y 280 31 are be VBP cord-299038-e0nsol3y 280 32 correct correct JJ cord-299038-e0nsol3y 280 33 Alleviation alleviation NN cord-299038-e0nsol3y 280 34 of of IN cord-299038-e0nsol3y 280 35 neurotoxicity neurotoxicity NN cord-299038-e0nsol3y 280 36 by by IN cord-299038-e0nsol3y 280 37 microglial microglial JJ cord-299038-e0nsol3y 280 38 human human JJ cord-299038-e0nsol3y 280 39 Siglec-11 Siglec-11 NNP cord-299038-e0nsol3y 280 40 Genetic Genetic NNP cord-299038-e0nsol3y 280 41 and and CC cord-299038-e0nsol3y 280 42 biochemical biochemical JJ cord-299038-e0nsol3y 280 43 modulation modulation NN cord-299038-e0nsol3y 280 44 of of IN cord-299038-e0nsol3y 280 45 sialic sialic JJ cord-299038-e0nsol3y 280 46 acid acid NN cord-299038-e0nsol3y 280 47 O o NN cord-299038-e0nsol3y 280 48 - - HYPH cord-299038-e0nsol3y 280 49 acetylation acetylation NN cord-299038-e0nsol3y 280 50 on on IN cord-299038-e0nsol3y 280 51 group group NN cord-299038-e0nsol3y 280 52 B B NNP cord-299038-e0nsol3y 280 53 Streptococcus streptococcus NN cord-299038-e0nsol3y 280 54 : : : cord-299038-e0nsol3y 280 55 phenotypic phenotypic JJ cord-299038-e0nsol3y 280 56 and and CC cord-299038-e0nsol3y 280 57 functional functional JJ cord-299038-e0nsol3y 280 58 impact impact NN cord-299038-e0nsol3y 280 59 O o NN cord-299038-e0nsol3y 280 60 - - HYPH cord-299038-e0nsol3y 280 61 Acetylation Acetylation NNP cord-299038-e0nsol3y 280 62 of of IN cord-299038-e0nsol3y 280 63 sialic sialic JJ cord-299038-e0nsol3y 280 64 acid acid NN cord-299038-e0nsol3y 280 65 on on IN cord-299038-e0nsol3y 280 66 Group Group NNP cord-299038-e0nsol3y 280 67 B B NNP cord-299038-e0nsol3y 280 68 Streptococcus Streptococcus NNP cord-299038-e0nsol3y 281 1 inhibits inhibit VBZ cord-299038-e0nsol3y 281 2 neutrophil neutrophil NN cord-299038-e0nsol3y 281 3 suppression suppression NN cord-299038-e0nsol3y 281 4 and and CC cord-299038-e0nsol3y 281 5 virulence virulence NN cord-299038-e0nsol3y 281 6 Definition definition NN cord-299038-e0nsol3y 281 7 of of IN cord-299038-e0nsol3y 281 8 a a DT cord-299038-e0nsol3y 281 9 bacterial bacterial JJ cord-299038-e0nsol3y 281 10 virulence virulence NN cord-299038-e0nsol3y 281 11 factor factor NN cord-299038-e0nsol3y 281 12 : : : cord-299038-e0nsol3y 282 1 sialylation sialylation NN cord-299038-e0nsol3y 282 2 of of IN cord-299038-e0nsol3y 282 3 the the DT cord-299038-e0nsol3y 282 4 group group NN cord-299038-e0nsol3y 282 5 B b NN cord-299038-e0nsol3y 282 6 streptococcal streptococcal JJ cord-299038-e0nsol3y 282 7 capsule capsule NN cord-299038-e0nsol3y 282 8 Effects effect NNS cord-299038-e0nsol3y 282 9 on on IN cord-299038-e0nsol3y 282 10 virulence virulence NN cord-299038-e0nsol3y 282 11 of of IN cord-299038-e0nsol3y 282 12 mutations mutation NNS cord-299038-e0nsol3y 282 13 in in IN cord-299038-e0nsol3y 282 14 a a DT cord-299038-e0nsol3y 282 15 locus locus NN cord-299038-e0nsol3y 282 16 essential essential JJ cord-299038-e0nsol3y 282 17 for for IN cord-299038-e0nsol3y 282 18 hyaluronic hyaluronic NN cord-299038-e0nsol3y 282 19 acid acid NN cord-299038-e0nsol3y 282 20 capsule capsule NN cord-299038-e0nsol3y 282 21 expression expression NN cord-299038-e0nsol3y 282 22 in in IN cord-299038-e0nsol3y 282 23 group group NN cord-299038-e0nsol3y 282 24 A a DT cord-299038-e0nsol3y 282 25 streptococci streptococcus NNS cord-299038-e0nsol3y 282 26 Peripheral peripheral JJ cord-299038-e0nsol3y 282 27 neuropathies neuropathy NNS cord-299038-e0nsol3y 282 28 and and CC cord-299038-e0nsol3y 282 29 anti anti JJ cord-299038-e0nsol3y 282 30 - - JJ cord-299038-e0nsol3y 282 31 glycolipid glycolipid JJ cord-299038-e0nsol3y 282 32 antibodies antibody NNS cord-299038-e0nsol3y 282 33 Guillain Guillain NNP cord-299038-e0nsol3y 282 34 - - HYPH cord-299038-e0nsol3y 282 35 Barre Barre NNP cord-299038-e0nsol3y 282 36 syndrome syndrome NN cord-299038-e0nsol3y 283 1 Recombinant recombinant JJ cord-299038-e0nsol3y 283 2 adenovirus adenovirus NN cord-299038-e0nsol3y 283 3 - - HYPH cord-299038-e0nsol3y 283 4 delivered deliver VBN cord-299038-e0nsol3y 283 5 soluble soluble JJ cord-299038-e0nsol3y 283 6 CD163 CD163 NNP cord-299038-e0nsol3y 283 7 and and CC cord-299038-e0nsol3y 283 8 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 283 9 receptors receptor NNS cord-299038-e0nsol3y 283 10 protected protect VBD cord-299038-e0nsol3y 283 11 pigs pig NNS cord-299038-e0nsol3y 283 12 from from IN cord-299038-e0nsol3y 283 13 porcine porcine JJ cord-299038-e0nsol3y 283 14 reproductive reproductive JJ cord-299038-e0nsol3y 283 15 and and CC cord-299038-e0nsol3y 283 16 respiratory respiratory JJ cord-299038-e0nsol3y 283 17 syndrome syndrome NN cord-299038-e0nsol3y 283 18 virus virus NN cord-299038-e0nsol3y 283 19 infection infection NN cord-299038-e0nsol3y 283 20 Molecular molecular JJ cord-299038-e0nsol3y 283 21 cloning clone VBG cord-299038-e0nsol3y 283 22 of of IN cord-299038-e0nsol3y 283 23 porcine porcine JJ cord-299038-e0nsol3y 283 24 Siglec-3 Siglec-3 NNP cord-299038-e0nsol3y 283 25 , , , cord-299038-e0nsol3y 283 26 Siglec-5 Siglec-5 NNP cord-299038-e0nsol3y 283 27 and and CC cord-299038-e0nsol3y 283 28 Siglec-10 Siglec-10 NNS cord-299038-e0nsol3y 283 29 , , , cord-299038-e0nsol3y 283 30 and and CC cord-299038-e0nsol3y 283 31 identification identification NN cord-299038-e0nsol3y 283 32 of of IN cord-299038-e0nsol3y 283 33 Siglec-10 siglec-10 NN cord-299038-e0nsol3y 283 34 as as IN cord-299038-e0nsol3y 283 35 an an DT cord-299038-e0nsol3y 283 36 alternative alternative JJ cord-299038-e0nsol3y 283 37 receptor receptor NN cord-299038-e0nsol3y 283 38 for for IN cord-299038-e0nsol3y 283 39 porcine porcine JJ cord-299038-e0nsol3y 283 40 reproductive reproductive JJ cord-299038-e0nsol3y 283 41 and and CC cord-299038-e0nsol3y 283 42 respiratory respiratory JJ cord-299038-e0nsol3y 283 43 syndrome syndrome NN cord-299038-e0nsol3y 283 44 virus virus NN cord-299038-e0nsol3y 283 45 ( ( -LRB- cord-299038-e0nsol3y 283 46 PRRSV PRRSV NNP cord-299038-e0nsol3y 283 47 ) ) -RRB- cord-299038-e0nsol3y 284 1 Deletion deletion NN cord-299038-e0nsol3y 284 2 polymorphism polymorphism NN cord-299038-e0nsol3y 284 3 of of IN cord-299038-e0nsol3y 284 4 SIGLEC14 siglec14 NN cord-299038-e0nsol3y 284 5 and and CC cord-299038-e0nsol3y 284 6 its -PRON- PRP$ cord-299038-e0nsol3y 284 7 functional functional JJ cord-299038-e0nsol3y 284 8 implications implication NNS cord-299038-e0nsol3y 285 1 Glycosphingolipid Glycosphingolipid NNP cord-299038-e0nsol3y 285 2 - - HYPH cord-299038-e0nsol3y 285 3 functionalized functionalize VBN cord-299038-e0nsol3y 285 4 nanoparticles nanoparticle NNS cord-299038-e0nsol3y 285 5 recapitulate recapitulate VBP cord-299038-e0nsol3y 285 6 CD169-dependent CD169-dependent NNP cord-299038-e0nsol3y 285 7 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 285 8 uptake uptake NN cord-299038-e0nsol3y 285 9 and and CC cord-299038-e0nsol3y 285 10 trafficking trafficking NN cord-299038-e0nsol3y 285 11 in in IN cord-299038-e0nsol3y 285 12 dendritic dendritic JJ cord-299038-e0nsol3y 285 13 cells cell NNS cord-299038-e0nsol3y 285 14 Siglec1 Siglec1 NNP cord-299038-e0nsol3y 285 15 suppresses suppress VBZ cord-299038-e0nsol3y 285 16 antiviral antiviral JJ cord-299038-e0nsol3y 285 17 innate innate JJ cord-299038-e0nsol3y 285 18 immune immune JJ cord-299038-e0nsol3y 285 19 response response NN cord-299038-e0nsol3y 285 20 by by IN cord-299038-e0nsol3y 285 21 inducing induce VBG cord-299038-e0nsol3y 285 22 TBK1 TBK1 NNP cord-299038-e0nsol3y 285 23 degradation degradation NN cord-299038-e0nsol3y 285 24 via via IN cord-299038-e0nsol3y 285 25 the the DT cord-299038-e0nsol3y 285 26 ubiquitin ubiquitin NN cord-299038-e0nsol3y 285 27 ligase ligase NN cord-299038-e0nsol3y 285 28 TRIM27 TRIM27 NNP cord-299038-e0nsol3y 285 29 Inhibition inhibition NN cord-299038-e0nsol3y 285 30 of of IN cord-299038-e0nsol3y 285 31 porcine porcine JJ cord-299038-e0nsol3y 285 32 reproductive reproductive JJ cord-299038-e0nsol3y 285 33 and and CC cord-299038-e0nsol3y 285 34 respiratory respiratory JJ cord-299038-e0nsol3y 285 35 syndrome syndrome NN cord-299038-e0nsol3y 285 36 virus virus NN cord-299038-e0nsol3y 285 37 infection infection NN cord-299038-e0nsol3y 285 38 by by IN cord-299038-e0nsol3y 285 39 recombinant recombinant JJ cord-299038-e0nsol3y 285 40 adenovirus adenovirus NN cord-299038-e0nsol3y 285 41 - - : cord-299038-e0nsol3y 285 42 and and CC cord-299038-e0nsol3y 285 43 / / SYM cord-299038-e0nsol3y 285 44 or or CC cord-299038-e0nsol3y 285 45 exosome exosome RB cord-299038-e0nsol3y 285 46 - - HYPH cord-299038-e0nsol3y 285 47 delivered deliver VBD cord-299038-e0nsol3y 285 48 the the DT cord-299038-e0nsol3y 285 49 artificial artificial JJ cord-299038-e0nsol3y 285 50 microRNAs microRNAs NNPS cord-299038-e0nsol3y 285 51 targeting target VBG cord-299038-e0nsol3y 286 1 sialoadhesin sialoadhesin NNP cord-299038-e0nsol3y 286 2 and and CC cord-299038-e0nsol3y 286 3 CD163 CD163 NNP cord-299038-e0nsol3y 286 4 receptors receptor NNS cord-299038-e0nsol3y 286 5 Siglecs Siglecs NNP cord-299038-e0nsol3y 286 6 facilitate facilitate VBP cord-299038-e0nsol3y 286 7 HIV-1 HIV-1 NNP cord-299038-e0nsol3y 286 8 infection infection NN cord-299038-e0nsol3y 286 9 of of IN cord-299038-e0nsol3y 286 10 macrophages macrophage NNS cord-299038-e0nsol3y 286 11 through through IN cord-299038-e0nsol3y 286 12 adhesion adhesion NN cord-299038-e0nsol3y 286 13 with with IN cord-299038-e0nsol3y 286 14 viral viral JJ cord-299038-e0nsol3y 286 15 sialic sialic JJ cord-299038-e0nsol3y 286 16 acids acid NNS