id sid tid token lemma pos cord-301692-zu0ubwfq 1 1 key key JJ cord-301692-zu0ubwfq 1 2 : : : cord-301692-zu0ubwfq 1 3 cord-301692-zu0ubwfq cord-301692-zu0ubwfq CD cord-301692-zu0ubwfq 1 4 authors author NNS cord-301692-zu0ubwfq 1 5 : : : cord-301692-zu0ubwfq 1 6 Mateu Mateu NNP cord-301692-zu0ubwfq 1 7 , , , cord-301692-zu0ubwfq 1 8 E. E. NNP cord-301692-zu0ubwfq 1 9 ; ; : cord-301692-zu0ubwfq 1 10 Diaz Diaz NNP cord-301692-zu0ubwfq 1 11 , , , cord-301692-zu0ubwfq 1 12 I. I. NNP cord-301692-zu0ubwfq 1 13 title title NN cord-301692-zu0ubwfq 1 14 : : : cord-301692-zu0ubwfq 2 1 The the DT cord-301692-zu0ubwfq 2 2 challenge challenge NN cord-301692-zu0ubwfq 2 3 of of IN cord-301692-zu0ubwfq 2 4 PRRS PRRS NNP cord-301692-zu0ubwfq 2 5 immunology immunology NN cord-301692-zu0ubwfq 2 6 date date NN cord-301692-zu0ubwfq 2 7 : : : cord-301692-zu0ubwfq 2 8 2007 2007 CD cord-301692-zu0ubwfq 2 9 - - HYPH cord-301692-zu0ubwfq 2 10 07 07 CD cord-301692-zu0ubwfq 2 11 - - HYPH cord-301692-zu0ubwfq 2 12 20 20 CD cord-301692-zu0ubwfq 2 13 journal journal NN cord-301692-zu0ubwfq 2 14 : : : cord-301692-zu0ubwfq 2 15 Vet Vet NNP cord-301692-zu0ubwfq 2 16 J J NNP cord-301692-zu0ubwfq 2 17 DOI DOI NNP cord-301692-zu0ubwfq 2 18 : : : cord-301692-zu0ubwfq 2 19 10.1016/ 10.1016/ CD cord-301692-zu0ubwfq 3 1 j.tvjl.2007.05.022 j.tvjl.2007.05.022 XX cord-301692-zu0ubwfq 4 1 sha sha NNP cord-301692-zu0ubwfq 4 2 : : : cord-301692-zu0ubwfq 4 3 1dbc2cf5296dfb4317275d42c1788a289cd689cb 1dbc2cf5296dfb4317275d42c1788a289cd689cb NNP cord-301692-zu0ubwfq 4 4 doc_id doc_id CD cord-301692-zu0ubwfq 4 5 : : : cord-301692-zu0ubwfq 4 6 301692 301692 CD cord-301692-zu0ubwfq 4 7 cord_uid cord_uid NNS cord-301692-zu0ubwfq 4 8 : : : cord-301692-zu0ubwfq 4 9 zu0ubwfq zu0ubwfq NFP cord-301692-zu0ubwfq 4 10 Porcine porcine JJ cord-301692-zu0ubwfq 4 11 reproductive reproductive JJ cord-301692-zu0ubwfq 4 12 and and CC cord-301692-zu0ubwfq 4 13 respiratory respiratory JJ cord-301692-zu0ubwfq 4 14 syndrome syndrome NN cord-301692-zu0ubwfq 4 15 ( ( -LRB- cord-301692-zu0ubwfq 4 16 PRRS PRRS NNP cord-301692-zu0ubwfq 4 17 ) ) -RRB- cord-301692-zu0ubwfq 5 1 is be VBZ cord-301692-zu0ubwfq 5 2 one one CD cord-301692-zu0ubwfq 5 3 of of IN cord-301692-zu0ubwfq 5 4 the the DT cord-301692-zu0ubwfq 5 5 most most RBS cord-301692-zu0ubwfq 5 6 challenging challenging JJ cord-301692-zu0ubwfq 5 7 subjects subject NNS cord-301692-zu0ubwfq 5 8 of of IN cord-301692-zu0ubwfq 5 9 research research NN cord-301692-zu0ubwfq 5 10 in in IN cord-301692-zu0ubwfq 5 11 veterinary veterinary JJ cord-301692-zu0ubwfq 5 12 viral viral JJ cord-301692-zu0ubwfq 5 13 immunology immunology NN cord-301692-zu0ubwfq 5 14 , , , cord-301692-zu0ubwfq 5 15 and and CC cord-301692-zu0ubwfq 5 16 the the DT cord-301692-zu0ubwfq 5 17 immune immune JJ cord-301692-zu0ubwfq 5 18 response response NN cord-301692-zu0ubwfq 5 19 against against IN cord-301692-zu0ubwfq 5 20 PRRS PRRS NNP cord-301692-zu0ubwfq 5 21 virus virus NN cord-301692-zu0ubwfq 5 22 ( ( -LRB- cord-301692-zu0ubwfq 5 23 PRRSV PRRSV NNP cord-301692-zu0ubwfq 5 24 ) ) -RRB- cord-301692-zu0ubwfq 5 25 still still RB cord-301692-zu0ubwfq 5 26 is be VBZ cord-301692-zu0ubwfq 5 27 poorly poorly RB cord-301692-zu0ubwfq 5 28 understood understand VBN cord-301692-zu0ubwfq 5 29 . . . cord-301692-zu0ubwfq 6 1 Infected infected JJ cord-301692-zu0ubwfq 6 2 pigs pig NNS cord-301692-zu0ubwfq 6 3 develop develop VBP cord-301692-zu0ubwfq 6 4 a a DT cord-301692-zu0ubwfq 6 5 strong strong JJ cord-301692-zu0ubwfq 6 6 and and CC cord-301692-zu0ubwfq 6 7 rapid rapid JJ cord-301692-zu0ubwfq 6 8 humoral humoral JJ cord-301692-zu0ubwfq 6 9 response response NN cord-301692-zu0ubwfq 6 10 but but CC cord-301692-zu0ubwfq 6 11 these these DT cord-301692-zu0ubwfq 6 12 initial initial JJ cord-301692-zu0ubwfq 6 13 antibodies antibody NNS cord-301692-zu0ubwfq 6 14 do do VBP cord-301692-zu0ubwfq 6 15 not not RB cord-301692-zu0ubwfq 6 16 confer confer VB cord-301692-zu0ubwfq 6 17 protection protection NN cord-301692-zu0ubwfq 6 18 and and CC cord-301692-zu0ubwfq 6 19 can can MD cord-301692-zu0ubwfq 6 20 even even RB cord-301692-zu0ubwfq 6 21 be be VB cord-301692-zu0ubwfq 6 22 harmful harmful JJ cord-301692-zu0ubwfq 6 23 by by IN cord-301692-zu0ubwfq 6 24 mediating mediate VBG cord-301692-zu0ubwfq 6 25 an an DT cord-301692-zu0ubwfq 6 26 antibody antibody NN cord-301692-zu0ubwfq 6 27 - - HYPH cord-301692-zu0ubwfq 6 28 dependent dependent JJ cord-301692-zu0ubwfq 6 29 enhancement enhancement NN cord-301692-zu0ubwfq 6 30 of of IN cord-301692-zu0ubwfq 6 31 disease disease NN cord-301692-zu0ubwfq 6 32 . . . cord-301692-zu0ubwfq 7 1 In in IN cord-301692-zu0ubwfq 7 2 contrast contrast NN cord-301692-zu0ubwfq 7 3 , , , cord-301692-zu0ubwfq 7 4 development development NN cord-301692-zu0ubwfq 7 5 of of IN cord-301692-zu0ubwfq 7 6 neutralising neutralise VBG cord-301692-zu0ubwfq 7 7 antibodies antibody NNS cord-301692-zu0ubwfq 7 8 ( ( -LRB- cord-301692-zu0ubwfq 7 9 NAs NAs NNP cord-301692-zu0ubwfq 7 10 ) ) -RRB- cord-301692-zu0ubwfq 7 11 is be VBZ cord-301692-zu0ubwfq 7 12 delayed delay VBN cord-301692-zu0ubwfq 7 13 and and CC cord-301692-zu0ubwfq 7 14 generation generation NN cord-301692-zu0ubwfq 7 15 of of IN cord-301692-zu0ubwfq 7 16 cell cell NN cord-301692-zu0ubwfq 7 17 - - HYPH cord-301692-zu0ubwfq 7 18 mediated mediate VBN cord-301692-zu0ubwfq 7 19 immune immune JJ cord-301692-zu0ubwfq 7 20 responses response NNS cord-301692-zu0ubwfq 7 21 , , , cord-301692-zu0ubwfq 7 22 such such JJ cord-301692-zu0ubwfq 7 23 as as IN cord-301692-zu0ubwfq 7 24 PRRSV PRRSV NNP cord-301692-zu0ubwfq 7 25 - - HYPH cord-301692-zu0ubwfq 7 26 specific specific JJ cord-301692-zu0ubwfq 7 27 interferon interferon NN cord-301692-zu0ubwfq 7 28 ( ( -LRB- cord-301692-zu0ubwfq 7 29 IFN)-γ ifn)-γ NN cord-301692-zu0ubwfq 7 30 secreting secrete VBG cord-301692-zu0ubwfq 7 31 cells cell NNS cord-301692-zu0ubwfq 7 32 , , , cord-301692-zu0ubwfq 7 33 is be VBZ cord-301692-zu0ubwfq 7 34 initially initially RB cord-301692-zu0ubwfq 7 35 erratic erratic JJ cord-301692-zu0ubwfq 7 36 . . . cord-301692-zu0ubwfq 8 1 In in IN cord-301692-zu0ubwfq 8 2 spite spite NN cord-301692-zu0ubwfq 8 3 of of IN cord-301692-zu0ubwfq 8 4 this this DT cord-301692-zu0ubwfq 8 5 , , , cord-301692-zu0ubwfq 8 6 induction induction NN cord-301692-zu0ubwfq 8 7 of of IN cord-301692-zu0ubwfq 8 8 strong strong JJ cord-301692-zu0ubwfq 8 9 and and CC cord-301692-zu0ubwfq 8 10 rapid rapid JJ cord-301692-zu0ubwfq 8 11 NAs NAs NNPS cord-301692-zu0ubwfq 8 12 and and CC cord-301692-zu0ubwfq 8 13 IFN IFN NNP cord-301692-zu0ubwfq 8 14 - - HYPH cord-301692-zu0ubwfq 8 15 γ γ NN cord-301692-zu0ubwfq 8 16 responses response NNS cord-301692-zu0ubwfq 8 17 seem seem VBP cord-301692-zu0ubwfq 8 18 to to TO cord-301692-zu0ubwfq 8 19 be be VB cord-301692-zu0ubwfq 8 20 required require VBN cord-301692-zu0ubwfq 8 21 for for IN cord-301692-zu0ubwfq 8 22 effective effective JJ cord-301692-zu0ubwfq 8 23 vaccination vaccination NN cord-301692-zu0ubwfq 8 24 . . . cord-301692-zu0ubwfq 9 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 9 2 strongly strongly RB cord-301692-zu0ubwfq 9 3 modulates modulate VBZ cord-301692-zu0ubwfq 9 4 the the DT cord-301692-zu0ubwfq 9 5 host host NN cord-301692-zu0ubwfq 9 6 ’s ’s POS cord-301692-zu0ubwfq 9 7 immune immune JJ cord-301692-zu0ubwfq 9 8 responses response NNS cord-301692-zu0ubwfq 9 9 . . . cord-301692-zu0ubwfq 10 1 The the DT cord-301692-zu0ubwfq 10 2 virus virus NN cord-301692-zu0ubwfq 10 3 inhibits inhibit VBZ cord-301692-zu0ubwfq 10 4 key key JJ cord-301692-zu0ubwfq 10 5 cytokines cytokine NNS cord-301692-zu0ubwfq 10 6 , , , cord-301692-zu0ubwfq 10 7 such such JJ cord-301692-zu0ubwfq 10 8 as as IN cord-301692-zu0ubwfq 10 9 IFN IFN NNP cord-301692-zu0ubwfq 10 10 - - HYPH cord-301692-zu0ubwfq 10 11 α α NNP cord-301692-zu0ubwfq 10 12 , , , cord-301692-zu0ubwfq 10 13 and and CC cord-301692-zu0ubwfq 10 14 may may MD cord-301692-zu0ubwfq 10 15 induce induce VB cord-301692-zu0ubwfq 10 16 regulatory regulatory JJ cord-301692-zu0ubwfq 10 17 cytokines cytokine NNS cord-301692-zu0ubwfq 10 18 , , , cord-301692-zu0ubwfq 10 19 such such JJ cord-301692-zu0ubwfq 10 20 as as IN cord-301692-zu0ubwfq 10 21 interleukin interleukin NN cord-301692-zu0ubwfq 10 22 ( ( -LRB- cord-301692-zu0ubwfq 10 23 IL)-10 il)-10 NN cord-301692-zu0ubwfq 10 24 . . . cord-301692-zu0ubwfq 11 1 Development Development NNP cord-301692-zu0ubwfq 11 2 of of IN cord-301692-zu0ubwfq 11 3 NAs NAs NNP cord-301692-zu0ubwfq 11 4 seems seem VBZ cord-301692-zu0ubwfq 11 5 to to TO cord-301692-zu0ubwfq 11 6 be be VB cord-301692-zu0ubwfq 11 7 impaired impair VBN cord-301692-zu0ubwfq 11 8 by by IN cord-301692-zu0ubwfq 11 9 the the DT cord-301692-zu0ubwfq 11 10 existence existence NN cord-301692-zu0ubwfq 11 11 of of IN cord-301692-zu0ubwfq 11 12 a a DT cord-301692-zu0ubwfq 11 13 decoy decoy NN cord-301692-zu0ubwfq 11 14 epitope epitope NN cord-301692-zu0ubwfq 11 15 close close RB cord-301692-zu0ubwfq 11 16 to to IN cord-301692-zu0ubwfq 11 17 the the DT cord-301692-zu0ubwfq 11 18 main main JJ cord-301692-zu0ubwfq 11 19 neutralisation neutralisation NN cord-301692-zu0ubwfq 11 20 epitope epitope NN cord-301692-zu0ubwfq 11 21 in in IN cord-301692-zu0ubwfq 11 22 glycoprotein glycoprotein NN cord-301692-zu0ubwfq 11 23 5 5 CD cord-301692-zu0ubwfq 11 24 . . . cord-301692-zu0ubwfq 12 1 This this DT cord-301692-zu0ubwfq 12 2 ability ability NN cord-301692-zu0ubwfq 12 3 to to TO cord-301692-zu0ubwfq 12 4 modulate modulate VB cord-301692-zu0ubwfq 12 5 the the DT cord-301692-zu0ubwfq 12 6 host host NN cord-301692-zu0ubwfq 12 7 immune immune JJ cord-301692-zu0ubwfq 12 8 response response NN cord-301692-zu0ubwfq 12 9 probably probably RB cord-301692-zu0ubwfq 12 10 varies vary VBZ cord-301692-zu0ubwfq 12 11 among among IN cord-301692-zu0ubwfq 12 12 strains strain NNS cord-301692-zu0ubwfq 12 13 or or CC cord-301692-zu0ubwfq 12 14 isolates isolate NNS cord-301692-zu0ubwfq 12 15 . . . cord-301692-zu0ubwfq 13 1 The the DT cord-301692-zu0ubwfq 13 2 genetic genetic JJ cord-301692-zu0ubwfq 13 3 diversity diversity NN cord-301692-zu0ubwfq 13 4 of of IN cord-301692-zu0ubwfq 13 5 the the DT cord-301692-zu0ubwfq 13 6 virus virus NN cord-301692-zu0ubwfq 13 7 is be VBZ cord-301692-zu0ubwfq 13 8 very very RB cord-301692-zu0ubwfq 13 9 high high JJ cord-301692-zu0ubwfq 13 10 and and CC cord-301692-zu0ubwfq 13 11 it -PRON- PRP cord-301692-zu0ubwfq 13 12 has have VBZ cord-301692-zu0ubwfq 13 13 been be VBN cord-301692-zu0ubwfq 13 14 shown show VBN cord-301692-zu0ubwfq 13 15 that that IN cord-301692-zu0ubwfq 13 16 this this DT cord-301692-zu0ubwfq 13 17 diversity diversity NN cord-301692-zu0ubwfq 13 18 can can MD cord-301692-zu0ubwfq 13 19 have have VB cord-301692-zu0ubwfq 13 20 serious serious JJ cord-301692-zu0ubwfq 13 21 implications implication NNS cord-301692-zu0ubwfq 13 22 for for IN cord-301692-zu0ubwfq 13 23 the the DT cord-301692-zu0ubwfq 13 24 development development NN cord-301692-zu0ubwfq 13 25 of of IN cord-301692-zu0ubwfq 13 26 vaccines vaccine NNS cord-301692-zu0ubwfq 13 27 , , , cord-301692-zu0ubwfq 13 28 since since IN cord-301692-zu0ubwfq 13 29 the the DT cord-301692-zu0ubwfq 13 30 immunity immunity NN cord-301692-zu0ubwfq 13 31 induced induce VBN cord-301692-zu0ubwfq 13 32 by by IN cord-301692-zu0ubwfq 13 33 one one CD cord-301692-zu0ubwfq 13 34 strain strain NN cord-301692-zu0ubwfq 13 35 may may MD cord-301692-zu0ubwfq 13 36 be be VB cord-301692-zu0ubwfq 13 37 only only RB cord-301692-zu0ubwfq 13 38 partial partial JJ cord-301692-zu0ubwfq 13 39 against against IN cord-301692-zu0ubwfq 13 40 a a DT cord-301692-zu0ubwfq 13 41 different different JJ cord-301692-zu0ubwfq 13 42 strain strain NN cord-301692-zu0ubwfq 13 43 , , , cord-301692-zu0ubwfq 13 44 even even RB cord-301692-zu0ubwfq 13 45 within within IN cord-301692-zu0ubwfq 13 46 the the DT cord-301692-zu0ubwfq 13 47 same same JJ cord-301692-zu0ubwfq 13 48 genotype genotype NN cord-301692-zu0ubwfq 13 49 . . . cord-301692-zu0ubwfq 14 1 With with IN cord-301692-zu0ubwfq 14 2 this this DT cord-301692-zu0ubwfq 14 3 panorama panorama NN cord-301692-zu0ubwfq 14 4 , , , cord-301692-zu0ubwfq 14 5 the the DT cord-301692-zu0ubwfq 14 6 development development NN cord-301692-zu0ubwfq 14 7 of of IN cord-301692-zu0ubwfq 14 8 newer new JJR cord-301692-zu0ubwfq 14 9 and and CC cord-301692-zu0ubwfq 14 10 universally universally RB cord-301692-zu0ubwfq 14 11 efficacious efficacious JJ cord-301692-zu0ubwfq 14 12 PRRSV PRRSV NNP cord-301692-zu0ubwfq 14 13 vaccines vaccine NNS cord-301692-zu0ubwfq 14 14 is be VBZ cord-301692-zu0ubwfq 14 15 challenging challenging JJ cord-301692-zu0ubwfq 14 16 , , , cord-301692-zu0ubwfq 14 17 but but CC cord-301692-zu0ubwfq 14 18 the the DT cord-301692-zu0ubwfq 14 19 present present JJ cord-301692-zu0ubwfq 14 20 state state NN cord-301692-zu0ubwfq 14 21 of of IN cord-301692-zu0ubwfq 14 22 knowledge knowledge NN cord-301692-zu0ubwfq 14 23 allows allow VBZ cord-301692-zu0ubwfq 14 24 optimism optimism NN cord-301692-zu0ubwfq 14 25 if if IN cord-301692-zu0ubwfq 14 26 collaborative collaborative JJ cord-301692-zu0ubwfq 14 27 efforts effort NNS cord-301692-zu0ubwfq 14 28 are be VBP cord-301692-zu0ubwfq 14 29 undertaken undertake VBN cord-301692-zu0ubwfq 14 30 in in IN cord-301692-zu0ubwfq 14 31 the the DT cord-301692-zu0ubwfq 14 32 scientific scientific JJ cord-301692-zu0ubwfq 14 33 community community NN cord-301692-zu0ubwfq 14 34 . . . cord-301692-zu0ubwfq 15 1 More More JJR cord-301692-zu0ubwfq 15 2 than than IN cord-301692-zu0ubwfq 15 3 15 15 CD cord-301692-zu0ubwfq 15 4 years year NNS cord-301692-zu0ubwfq 15 5 after after IN cord-301692-zu0ubwfq 15 6 the the DT cord-301692-zu0ubwfq 15 7 emergence emergence NN cord-301692-zu0ubwfq 15 8 of of IN cord-301692-zu0ubwfq 15 9 porcine porcine JJ cord-301692-zu0ubwfq 15 10 reproductive reproductive JJ cord-301692-zu0ubwfq 15 11 and and CC cord-301692-zu0ubwfq 15 12 respiratory respiratory JJ cord-301692-zu0ubwfq 15 13 syndrome syndrome NN cord-301692-zu0ubwfq 15 14 ( ( -LRB- cord-301692-zu0ubwfq 15 15 PRRS PRRS NNP cord-301692-zu0ubwfq 15 16 ) ) -RRB- cord-301692-zu0ubwfq 15 17 , , , cord-301692-zu0ubwfq 15 18 our -PRON- PRP$ cord-301692-zu0ubwfq 15 19 understanding understanding NN cord-301692-zu0ubwfq 15 20 of of IN cord-301692-zu0ubwfq 15 21 the the DT cord-301692-zu0ubwfq 15 22 disease disease NN cord-301692-zu0ubwfq 15 23 still still RB cord-301692-zu0ubwfq 15 24 is be VBZ cord-301692-zu0ubwfq 15 25 far far RB cord-301692-zu0ubwfq 15 26 from from IN cord-301692-zu0ubwfq 15 27 complete complete JJ cord-301692-zu0ubwfq 15 28 . . . cord-301692-zu0ubwfq 16 1 The the DT cord-301692-zu0ubwfq 16 2 clinical clinical JJ cord-301692-zu0ubwfq 16 3 features feature NNS cord-301692-zu0ubwfq 16 4 of of IN cord-301692-zu0ubwfq 16 5 PRRS PRRS NNP cord-301692-zu0ubwfq 16 6 are be VBP cord-301692-zu0ubwfq 16 7 well well RB cord-301692-zu0ubwfq 16 8 known know VBN cord-301692-zu0ubwfq 16 9 , , , cord-301692-zu0ubwfq 16 10 a a DT cord-301692-zu0ubwfq 16 11 global global JJ cord-301692-zu0ubwfq 16 12 picture picture NN cord-301692-zu0ubwfq 16 13 of of IN cord-301692-zu0ubwfq 16 14 the the DT cord-301692-zu0ubwfq 16 15 epidemiology epidemiology NN cord-301692-zu0ubwfq 16 16 has have VBZ cord-301692-zu0ubwfq 16 17 been be VBN cord-301692-zu0ubwfq 16 18 drawn draw VBN cord-301692-zu0ubwfq 16 19 , , , cord-301692-zu0ubwfq 16 20 although although IN cord-301692-zu0ubwfq 16 21 some some DT cord-301692-zu0ubwfq 16 22 gaps gap NNS cord-301692-zu0ubwfq 16 23 remain remain VBP cord-301692-zu0ubwfq 16 24 to to TO cord-301692-zu0ubwfq 16 25 be be VB cord-301692-zu0ubwfq 16 26 filled fill VBN cord-301692-zu0ubwfq 16 27 , , , cord-301692-zu0ubwfq 16 28 management management NN cord-301692-zu0ubwfq 16 29 and and CC cord-301692-zu0ubwfq 16 30 husbandry husbandry NN cord-301692-zu0ubwfq 16 31 procedures procedure NNS cord-301692-zu0ubwfq 16 32 have have VBP cord-301692-zu0ubwfq 16 33 been be VBN cord-301692-zu0ubwfq 16 34 devised devise VBN cord-301692-zu0ubwfq 16 35 for for IN cord-301692-zu0ubwfq 16 36 controlling control VBG cord-301692-zu0ubwfq 16 37 the the DT cord-301692-zu0ubwfq 16 38 disease disease NN cord-301692-zu0ubwfq 16 39 and and CC cord-301692-zu0ubwfq 16 40 vaccines vaccine NNS cord-301692-zu0ubwfq 16 41 are be VBP cord-301692-zu0ubwfq 16 42 available available JJ cord-301692-zu0ubwfq 16 43 . . . cord-301692-zu0ubwfq 17 1 However however RB cord-301692-zu0ubwfq 17 2 , , , cord-301692-zu0ubwfq 17 3 infection infection NN cord-301692-zu0ubwfq 17 4 by by IN cord-301692-zu0ubwfq 17 5 PRRS PRRS NNP cord-301692-zu0ubwfq 17 6 virus virus NN cord-301692-zu0ubwfq 17 7 ( ( -LRB- cord-301692-zu0ubwfq 17 8 PRRSV PRRSV NNP cord-301692-zu0ubwfq 17 9 ) ) -RRB- cord-301692-zu0ubwfq 17 10 is be VBZ cord-301692-zu0ubwfq 17 11 still still RB cord-301692-zu0ubwfq 17 12 widespread widespread JJ cord-301692-zu0ubwfq 17 13 and and CC cord-301692-zu0ubwfq 17 14 the the DT cord-301692-zu0ubwfq 17 15 virus virus NN cord-301692-zu0ubwfq 17 16 is be VBZ cord-301692-zu0ubwfq 17 17 frequently frequently RB cord-301692-zu0ubwfq 17 18 reintroduced reintroduce VBN cord-301692-zu0ubwfq 17 19 to to IN cord-301692-zu0ubwfq 17 20 farms farm NNS cord-301692-zu0ubwfq 17 21 after after IN cord-301692-zu0ubwfq 17 22 eradication eradication NN cord-301692-zu0ubwfq 17 23 . . . cord-301692-zu0ubwfq 18 1 What what WP cord-301692-zu0ubwfq 18 2 are be VBP cord-301692-zu0ubwfq 18 3 the the DT cord-301692-zu0ubwfq 18 4 reasons reason NNS cord-301692-zu0ubwfq 18 5 for for IN cord-301692-zu0ubwfq 18 6 such such JJ cord-301692-zu0ubwfq 18 7 failures failure NNS cord-301692-zu0ubwfq 18 8 ? ? . cord-301692-zu0ubwfq 19 1 The the DT cord-301692-zu0ubwfq 19 2 answer answer NN cord-301692-zu0ubwfq 19 3 is be VBZ cord-301692-zu0ubwfq 19 4 not not RB cord-301692-zu0ubwfq 19 5 simple simple JJ cord-301692-zu0ubwfq 19 6 , , , cord-301692-zu0ubwfq 19 7 but but CC cord-301692-zu0ubwfq 19 8 examination examination NN cord-301692-zu0ubwfq 19 9 of of IN cord-301692-zu0ubwfq 19 10 the the DT cord-301692-zu0ubwfq 19 11 scientific scientific JJ cord-301692-zu0ubwfq 19 12 literature literature NN cord-301692-zu0ubwfq 19 13 and and CC cord-301692-zu0ubwfq 19 14 problems problem NNS cord-301692-zu0ubwfq 19 15 reported report VBN cord-301692-zu0ubwfq 19 16 by by IN cord-301692-zu0ubwfq 19 17 pig pig NN cord-301692-zu0ubwfq 19 18 veterinarians veterinarian NNS cord-301692-zu0ubwfq 19 19 indicates indicate VBZ cord-301692-zu0ubwfq 19 20 that that IN cord-301692-zu0ubwfq 19 21 vaccines vaccine NNS cord-301692-zu0ubwfq 19 22 can can MD cord-301692-zu0ubwfq 19 23 be be VB cord-301692-zu0ubwfq 19 24 a a DT cord-301692-zu0ubwfq 19 25 useful useful JJ cord-301692-zu0ubwfq 19 26 tool tool NN cord-301692-zu0ubwfq 19 27 , , , cord-301692-zu0ubwfq 19 28 although although IN cord-301692-zu0ubwfq 19 29 their -PRON- PRP$ cord-301692-zu0ubwfq 19 30 efficacy efficacy NN cord-301692-zu0ubwfq 19 31 is be VBZ cord-301692-zu0ubwfq 19 32 far far RB cord-301692-zu0ubwfq 19 33 from from IN cord-301692-zu0ubwfq 19 34 being be VBG cord-301692-zu0ubwfq 19 35 universal universal JJ cord-301692-zu0ubwfq 19 36 and and CC cord-301692-zu0ubwfq 19 37 complete complete JJ cord-301692-zu0ubwfq 19 38 . . . cord-301692-zu0ubwfq 20 1 The the DT cord-301692-zu0ubwfq 20 2 approach approach NN cord-301692-zu0ubwfq 20 3 of of IN cord-301692-zu0ubwfq 20 4 ' ' `` cord-301692-zu0ubwfq 20 5 ' ' `` cord-301692-zu0ubwfq 20 6 let let VB cord-301692-zu0ubwfq 20 7 's 's PRP cord-301692-zu0ubwfq 20 8 take take VB cord-301692-zu0ubwfq 20 9 a a DT cord-301692-zu0ubwfq 20 10 strain strain NN cord-301692-zu0ubwfq 20 11 , , , cord-301692-zu0ubwfq 20 12 let let VB cord-301692-zu0ubwfq 20 13 's -PRON- PRP cord-301692-zu0ubwfq 20 14 attenuate attenuate VB cord-301692-zu0ubwfq 20 15 or or CC cord-301692-zu0ubwfq 20 16 inactivate inactivate VB cord-301692-zu0ubwfq 20 17 it -PRON- PRP cord-301692-zu0ubwfq 20 18 and and CC cord-301692-zu0ubwfq 20 19 , , , cord-301692-zu0ubwfq 20 20 voilà voilà FW cord-301692-zu0ubwfq 20 21 ! ! . cord-301692-zu0ubwfq 21 1 the the DT cord-301692-zu0ubwfq 21 2 vaccine vaccine NN cord-301692-zu0ubwfq 21 3 will will MD cord-301692-zu0ubwfq 21 4 generate generate VB cord-301692-zu0ubwfq 21 5 sufficient sufficient JJ cord-301692-zu0ubwfq 21 6 immunity immunity NN cord-301692-zu0ubwfq 21 7 to to TO cord-301692-zu0ubwfq 21 8 protect protect VB cord-301692-zu0ubwfq 21 9 against against IN cord-301692-zu0ubwfq 21 10 the the DT cord-301692-zu0ubwfq 21 11 disease disease NN cord-301692-zu0ubwfq 21 12 ' ' '' cord-301692-zu0ubwfq 21 13 ' ' '' cord-301692-zu0ubwfq 21 14 is be VBZ cord-301692-zu0ubwfq 21 15 not not RB cord-301692-zu0ubwfq 21 16 valid valid JJ cord-301692-zu0ubwfq 21 17 for for IN cord-301692-zu0ubwfq 21 18 PRRSV PRRSV NNP cord-301692-zu0ubwfq 21 19 . . . cord-301692-zu0ubwfq 22 1 The the DT cord-301692-zu0ubwfq 22 2 present present JJ cord-301692-zu0ubwfq 22 3 review review NN cord-301692-zu0ubwfq 22 4 discusses discuss VBZ cord-301692-zu0ubwfq 22 5 what what WP cord-301692-zu0ubwfq 22 6 is be VBZ cord-301692-zu0ubwfq 22 7 known know VBN cord-301692-zu0ubwfq 22 8 and and CC cord-301692-zu0ubwfq 22 9 what what WDT cord-301692-zu0ubwfq 22 10 gaps gap NNS cord-301692-zu0ubwfq 22 11 remain remain VBP cord-301692-zu0ubwfq 22 12 in in IN cord-301692-zu0ubwfq 22 13 our -PRON- PRP$ cord-301692-zu0ubwfq 22 14 understanding understanding NN cord-301692-zu0ubwfq 22 15 of of IN cord-301692-zu0ubwfq 22 16 PRRSV PRRSV NNP cord-301692-zu0ubwfq 22 17 immunity immunity NN cord-301692-zu0ubwfq 22 18 and and CC cord-301692-zu0ubwfq 22 19 its -PRON- PRP$ cord-301692-zu0ubwfq 22 20 immunopathogenesis immunopathogenesis NN cord-301692-zu0ubwfq 22 21 . . . cord-301692-zu0ubwfq 23 1 It -PRON- PRP cord-301692-zu0ubwfq 23 2 concludes conclude VBZ cord-301692-zu0ubwfq 23 3 with with IN cord-301692-zu0ubwfq 23 4 the the DT cord-301692-zu0ubwfq 23 5 positive positive JJ cord-301692-zu0ubwfq 23 6 message message NN cord-301692-zu0ubwfq 23 7 that that WDT cord-301692-zu0ubwfq 23 8 currently currently RB cord-301692-zu0ubwfq 23 9 available available JJ cord-301692-zu0ubwfq 23 10 information information NN cord-301692-zu0ubwfq 23 11 should should MD cord-301692-zu0ubwfq 23 12 allow allow VB cord-301692-zu0ubwfq 23 13 us -PRON- PRP cord-301692-zu0ubwfq 23 14 to to TO cord-301692-zu0ubwfq 23 15 identify identify VB cord-301692-zu0ubwfq 23 16 the the DT cord-301692-zu0ubwfq 23 17 crucial crucial JJ cord-301692-zu0ubwfq 23 18 points point NNS cord-301692-zu0ubwfq 23 19 that that WDT cord-301692-zu0ubwfq 23 20 need need VBP cord-301692-zu0ubwfq 23 21 to to TO cord-301692-zu0ubwfq 23 22 be be VB cord-301692-zu0ubwfq 23 23 studied study VBN cord-301692-zu0ubwfq 23 24 in in IN cord-301692-zu0ubwfq 23 25 order order NN cord-301692-zu0ubwfq 23 26 to to TO cord-301692-zu0ubwfq 23 27 understand understand VB cord-301692-zu0ubwfq 23 28 the the DT cord-301692-zu0ubwfq 23 29 disease disease NN cord-301692-zu0ubwfq 23 30 and and CC cord-301692-zu0ubwfq 23 31 overcome overcome VB cord-301692-zu0ubwfq 23 32 the the DT cord-301692-zu0ubwfq 23 33 challenge challenge NN cord-301692-zu0ubwfq 23 34 of of IN cord-301692-zu0ubwfq 23 35 PRRSV PRRSV NNP cord-301692-zu0ubwfq 23 36 immunology immunology NNP cord-301692-zu0ubwfq 23 37 . . . cord-301692-zu0ubwfq 24 1 Adaptive adaptive JJ cord-301692-zu0ubwfq 24 2 immune immune JJ cord-301692-zu0ubwfq 24 3 response response NN cord-301692-zu0ubwfq 24 4 to to IN cord-301692-zu0ubwfq 24 5 PRRSV PRRSV NNP cord-301692-zu0ubwfq 25 1 The the DT cord-301692-zu0ubwfq 25 2 development development NN cord-301692-zu0ubwfq 25 3 of of IN cord-301692-zu0ubwfq 25 4 adaptive adaptive JJ cord-301692-zu0ubwfq 25 5 immunity immunity NN cord-301692-zu0ubwfq 25 6 against against IN cord-301692-zu0ubwfq 25 7 PRRSV PRRSV NNP cord-301692-zu0ubwfq 25 8 is be VBZ cord-301692-zu0ubwfq 25 9 a a DT cord-301692-zu0ubwfq 25 10 tale tale NN cord-301692-zu0ubwfq 25 11 of of IN cord-301692-zu0ubwfq 25 12 unusual unusual JJ cord-301692-zu0ubwfq 25 13 features feature NNS cord-301692-zu0ubwfq 25 14 in in IN cord-301692-zu0ubwfq 25 15 both both CC cord-301692-zu0ubwfq 25 16 the the DT cord-301692-zu0ubwfq 25 17 humoral humoral JJ cord-301692-zu0ubwfq 25 18 and and CC cord-301692-zu0ubwfq 25 19 cellular cellular JJ cord-301692-zu0ubwfq 25 20 components component NNS cord-301692-zu0ubwfq 25 21 of of IN cord-301692-zu0ubwfq 25 22 the the DT cord-301692-zu0ubwfq 25 23 immune immune JJ cord-301692-zu0ubwfq 25 24 response response NN cord-301692-zu0ubwfq 25 25 . . . cord-301692-zu0ubwfq 26 1 Circulating circulate VBG cord-301692-zu0ubwfq 26 2 antibodies antibody NNS cord-301692-zu0ubwfq 26 3 against against IN cord-301692-zu0ubwfq 26 4 PRRSV PRRSV NNP cord-301692-zu0ubwfq 26 5 are be VBP cord-301692-zu0ubwfq 26 6 detectable detectable JJ cord-301692-zu0ubwfq 26 7 in in IN cord-301692-zu0ubwfq 26 8 some some DT cord-301692-zu0ubwfq 26 9 pigs pig NNS cord-301692-zu0ubwfq 26 10 by by IN cord-301692-zu0ubwfq 26 11 days day NNS cord-301692-zu0ubwfq 26 12 5 5 CD cord-301692-zu0ubwfq 26 13 - - SYM cord-301692-zu0ubwfq 26 14 7 7 CD cord-301692-zu0ubwfq 26 15 post post NN cord-301692-zu0ubwfq 26 16 - - NN cord-301692-zu0ubwfq 26 17 infection infection JJ cord-301692-zu0ubwfq 26 18 ( ( -LRB- cord-301692-zu0ubwfq 26 19 PI pi NN cord-301692-zu0ubwfq 26 20 ) ) -RRB- cord-301692-zu0ubwfq 26 21 and and CC cord-301692-zu0ubwfq 26 22 all all DT cord-301692-zu0ubwfq 26 23 animals animal NNS cord-301692-zu0ubwfq 26 24 have have VBP cord-301692-zu0ubwfq 26 25 seroconverted seroconverte VBN cord-301692-zu0ubwfq 26 26 by by IN cord-301692-zu0ubwfq 26 27 day day NN cord-301692-zu0ubwfq 26 28 14 14 CD cord-301692-zu0ubwfq 26 29 PI pi NN cord-301692-zu0ubwfq 27 1 ( ( -LRB- cord-301692-zu0ubwfq 27 2 Yoon Yoon NNP cord-301692-zu0ubwfq 27 3 et et FW cord-301692-zu0ubwfq 27 4 al al NNP cord-301692-zu0ubwfq 27 5 . . NNP cord-301692-zu0ubwfq 27 6 , , , cord-301692-zu0ubwfq 27 7 1992 1992 CD cord-301692-zu0ubwfq 28 1 ( ( -LRB- cord-301692-zu0ubwfq 28 2 Yoon Yoon NNP cord-301692-zu0ubwfq 28 3 et et FW cord-301692-zu0ubwfq 28 4 al al NNP cord-301692-zu0ubwfq 28 5 . . NNP cord-301692-zu0ubwfq 28 6 , , , cord-301692-zu0ubwfq 28 7 , , , cord-301692-zu0ubwfq 28 8 1995 1995 CD cord-301692-zu0ubwfq 28 9 . . . cord-301692-zu0ubwfq 29 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 29 2 - - HYPH cord-301692-zu0ubwfq 29 3 specific specific JJ cord-301692-zu0ubwfq 29 4 immunoglobulin immunoglobulin NN cord-301692-zu0ubwfq 29 5 M M NNP cord-301692-zu0ubwfq 29 6 ( ( -LRB- cord-301692-zu0ubwfq 29 7 IgM IgM NNP cord-301692-zu0ubwfq 29 8 ) ) -RRB- cord-301692-zu0ubwfq 29 9 reaches reach VBZ cord-301692-zu0ubwfq 29 10 a a DT cord-301692-zu0ubwfq 29 11 peak peak NN cord-301692-zu0ubwfq 29 12 at at IN cord-301692-zu0ubwfq 29 13 day day NN cord-301692-zu0ubwfq 29 14 14 14 CD cord-301692-zu0ubwfq 29 15 PI pi NN cord-301692-zu0ubwfq 29 16 and and CC cord-301692-zu0ubwfq 29 17 then then RB cord-301692-zu0ubwfq 29 18 declines decline VBZ cord-301692-zu0ubwfq 29 19 to to IN cord-301692-zu0ubwfq 29 20 undetectable undetectable JJ cord-301692-zu0ubwfq 29 21 levels level NNS cord-301692-zu0ubwfq 29 22 by by IN cord-301692-zu0ubwfq 29 23 42 42 CD cord-301692-zu0ubwfq 29 24 days day NNS cord-301692-zu0ubwfq 29 25 PI PI NNP cord-301692-zu0ubwfq 29 26 . . . cord-301692-zu0ubwfq 30 1 Concentrations concentration NNS cord-301692-zu0ubwfq 30 2 of of IN cord-301692-zu0ubwfq 30 3 IgG IgG NNP cord-301692-zu0ubwfq 30 4 reach reach VBP cord-301692-zu0ubwfq 30 5 a a DT cord-301692-zu0ubwfq 30 6 maximum maximum NN cord-301692-zu0ubwfq 30 7 at at IN cord-301692-zu0ubwfq 30 8 21 21 CD cord-301692-zu0ubwfq 30 9 - - SYM cord-301692-zu0ubwfq 30 10 49 49 CD cord-301692-zu0ubwfq 30 11 days day NNS cord-301692-zu0ubwfq 30 12 PI PI NNP cord-301692-zu0ubwfq 30 13 ( ( -LRB- cord-301692-zu0ubwfq 30 14 Vezina Vezina NNP cord-301692-zu0ubwfq 30 15 et et NNP cord-301692-zu0ubwfq 30 16 al al NNP cord-301692-zu0ubwfq 30 17 . . . cord-301692-zu0ubwfq 31 1 , , , cord-301692-zu0ubwfq 31 2 1996 1996 CD cord-301692-zu0ubwfq 31 3 ; ; : cord-301692-zu0ubwfq 31 4 Loemba Loemba NNP cord-301692-zu0ubwfq 31 5 et et FW cord-301692-zu0ubwfq 31 6 al al NNP cord-301692-zu0ubwfq 31 7 . . NNP cord-301692-zu0ubwfq 31 8 , , , cord-301692-zu0ubwfq 31 9 1996 1996 CD cord-301692-zu0ubwfq 31 10 ) ) -RRB- cord-301692-zu0ubwfq 31 11 . . . cord-301692-zu0ubwfq 32 1 However however RB cord-301692-zu0ubwfq 32 2 , , , cord-301692-zu0ubwfq 32 3 this this DT cord-301692-zu0ubwfq 32 4 rapid rapid JJ cord-301692-zu0ubwfq 32 5 IgM IgM NNP cord-301692-zu0ubwfq 32 6 and and CC cord-301692-zu0ubwfq 32 7 IgG IgG NNP cord-301692-zu0ubwfq 32 8 response response NN cord-301692-zu0ubwfq 32 9 does do VBZ cord-301692-zu0ubwfq 32 10 not not RB cord-301692-zu0ubwfq 32 11 correspond correspond VB cord-301692-zu0ubwfq 32 12 to to IN cord-301692-zu0ubwfq 32 13 neutralising neutralise VBG cord-301692-zu0ubwfq 32 14 antibodies antibody NNS cord-301692-zu0ubwfq 32 15 ( ( -LRB- cord-301692-zu0ubwfq 32 16 NAs NAs NNP cord-301692-zu0ubwfq 32 17 ) ) -RRB- cord-301692-zu0ubwfq 32 18 ( ( -LRB- cord-301692-zu0ubwfq 32 19 Yoon Yoon NNP cord-301692-zu0ubwfq 32 20 et et FW cord-301692-zu0ubwfq 32 21 al al NNP cord-301692-zu0ubwfq 32 22 . . NNP cord-301692-zu0ubwfq 32 23 , , , cord-301692-zu0ubwfq 32 24 1994 1994 CD cord-301692-zu0ubwfq 32 25 ) ) -RRB- cord-301692-zu0ubwfq 32 26 . . . cord-301692-zu0ubwfq 33 1 Nelson Nelson NNP cord-301692-zu0ubwfq 33 2 et et NNP cord-301692-zu0ubwfq 33 3 al al NNP cord-301692-zu0ubwfq 33 4 . . . cord-301692-zu0ubwfq 34 1 ( ( -LRB- cord-301692-zu0ubwfq 34 2 1994 1994 CD cord-301692-zu0ubwfq 34 3 ) ) -RRB- cord-301692-zu0ubwfq 34 4 studied study VBD cord-301692-zu0ubwfq 34 5 the the DT cord-301692-zu0ubwfq 34 6 kinetics kinetic NNS cord-301692-zu0ubwfq 34 7 of of IN cord-301692-zu0ubwfq 34 8 the the DT cord-301692-zu0ubwfq 34 9 humoral humoral JJ cord-301692-zu0ubwfq 34 10 response response NN cord-301692-zu0ubwfq 34 11 of of IN cord-301692-zu0ubwfq 34 12 pigs pig NNS cord-301692-zu0ubwfq 34 13 against against IN cord-301692-zu0ubwfq 34 14 an an DT cord-301692-zu0ubwfq 34 15 American american JJ cord-301692-zu0ubwfq 34 16 strain strain NN cord-301692-zu0ubwfq 34 17 of of IN cord-301692-zu0ubwfq 34 18 PRRSV PRRSV NNP cord-301692-zu0ubwfq 34 19 . . . cord-301692-zu0ubwfq 35 1 The the DT cord-301692-zu0ubwfq 35 2 earliest early JJS cord-301692-zu0ubwfq 35 3 antibodies antibody NNS cord-301692-zu0ubwfq 35 4 were be VBD cord-301692-zu0ubwfq 35 5 directed direct VBN cord-301692-zu0ubwfq 35 6 against against IN cord-301692-zu0ubwfq 35 7 the the DT cord-301692-zu0ubwfq 35 8 15 15 CD cord-301692-zu0ubwfq 35 9 KDa KDa NNP cord-301692-zu0ubwfq 35 10 nucleoprotein nucleoprotein NNP cord-301692-zu0ubwfq 35 11 , , , cord-301692-zu0ubwfq 35 12 followed follow VBN cord-301692-zu0ubwfq 35 13 by by IN cord-301692-zu0ubwfq 35 14 the the DT cord-301692-zu0ubwfq 35 15 19 19 CD cord-301692-zu0ubwfq 35 16 KDa KDa NNS cord-301692-zu0ubwfq 35 17 M M NNP cord-301692-zu0ubwfq 35 18 protein protein NN cord-301692-zu0ubwfq 35 19 , , , cord-301692-zu0ubwfq 35 20 then then RB cord-301692-zu0ubwfq 35 21 the the DT cord-301692-zu0ubwfq 35 22 26 26 CD cord-301692-zu0ubwfq 35 23 KDa KDa NNS cord-301692-zu0ubwfq 35 24 glycoprotein glycoprotein NN cord-301692-zu0ubwfq 35 25 5 5 CD cord-301692-zu0ubwfq 35 26 ( ( -LRB- cord-301692-zu0ubwfq 35 27 GP5 GP5 NNP cord-301692-zu0ubwfq 35 28 ) ) -RRB- cord-301692-zu0ubwfq 35 29 . . . cord-301692-zu0ubwfq 36 1 Other other JJ cord-301692-zu0ubwfq 36 2 studies study NNS cord-301692-zu0ubwfq 36 3 showed show VBD cord-301692-zu0ubwfq 36 4 that that IN cord-301692-zu0ubwfq 36 5 non non JJ cord-301692-zu0ubwfq 36 6 - - JJ cord-301692-zu0ubwfq 36 7 structural structural JJ cord-301692-zu0ubwfq 36 8 protein protein NN cord-301692-zu0ubwfq 36 9 2 2 CD cord-301692-zu0ubwfq 36 10 ( ( -LRB- cord-301692-zu0ubwfq 36 11 nsp2 nsp2 NNP cord-301692-zu0ubwfq 36 12 ) ) -RRB- cord-301692-zu0ubwfq 36 13 contains contain VBZ cord-301692-zu0ubwfq 36 14 a a DT cord-301692-zu0ubwfq 36 15 cluster cluster NN cord-301692-zu0ubwfq 36 16 of of IN cord-301692-zu0ubwfq 36 17 non non JJ cord-301692-zu0ubwfq 36 18 - - JJ cord-301692-zu0ubwfq 36 19 neutralising neutralising JJ cord-301692-zu0ubwfq 36 20 B b NN cord-301692-zu0ubwfq 36 21 - - HYPH cord-301692-zu0ubwfq 36 22 epitopes epitope NNS cord-301692-zu0ubwfq 36 23 and and CC cord-301692-zu0ubwfq 36 24 probably probably RB cord-301692-zu0ubwfq 36 25 is be VBZ cord-301692-zu0ubwfq 36 26 the the DT cord-301692-zu0ubwfq 36 27 immunodominant immunodominant JJ cord-301692-zu0ubwfq 36 28 protein protein NN cord-301692-zu0ubwfq 36 29 of of IN cord-301692-zu0ubwfq 36 30 PRRSV PRRSV NNP cord-301692-zu0ubwfq 37 1 ( ( -LRB- cord-301692-zu0ubwfq 37 2 Oleksiewicz Oleksiewicz NNP cord-301692-zu0ubwfq 37 3 et et NNP cord-301692-zu0ubwfq 37 4 al al NNP cord-301692-zu0ubwfq 37 5 . . NNP cord-301692-zu0ubwfq 37 6 , , , cord-301692-zu0ubwfq 37 7 2001 2001 CD cord-301692-zu0ubwfq 37 8 ; ; : cord-301692-zu0ubwfq 37 9 de de NNP cord-301692-zu0ubwfq 37 10 Lima Lima NNP cord-301692-zu0ubwfq 37 11 et et NNP cord-301692-zu0ubwfq 37 12 al al NNP cord-301692-zu0ubwfq 37 13 . . NNP cord-301692-zu0ubwfq 37 14 , , , cord-301692-zu0ubwfq 37 15 2006 2006 CD cord-301692-zu0ubwfq 37 16 ) ) -RRB- cord-301692-zu0ubwfq 37 17 . . . cord-301692-zu0ubwfq 38 1 Most Most JJS cord-301692-zu0ubwfq 38 2 diagnostic diagnostic JJ cord-301692-zu0ubwfq 38 3 tests test NNS cord-301692-zu0ubwfq 38 4 detect detect VBP cord-301692-zu0ubwfq 38 5 antibodies antibody NNS cord-301692-zu0ubwfq 38 6 mainly mainly RB cord-301692-zu0ubwfq 38 7 against against IN cord-301692-zu0ubwfq 38 8 the the DT cord-301692-zu0ubwfq 38 9 N N NNP cord-301692-zu0ubwfq 38 10 protein protein NN cord-301692-zu0ubwfq 38 11 . . . cord-301692-zu0ubwfq 39 1 These these DT cord-301692-zu0ubwfq 39 2 antibodies antibody NNS cord-301692-zu0ubwfq 39 3 appear appear VBP cord-301692-zu0ubwfq 39 4 around around IN cord-301692-zu0ubwfq 39 5 the the DT cord-301692-zu0ubwfq 39 6 first first JJ cord-301692-zu0ubwfq 39 7 week week NN cord-301692-zu0ubwfq 39 8 PI pi NN cord-301692-zu0ubwfq 39 9 and and CC cord-301692-zu0ubwfq 39 10 persist persist VB cord-301692-zu0ubwfq 39 11 for for IN cord-301692-zu0ubwfq 39 12 several several JJ cord-301692-zu0ubwfq 39 13 months month NNS cord-301692-zu0ubwfq 39 14 , , , cord-301692-zu0ubwfq 39 15 but but CC cord-301692-zu0ubwfq 39 16 do do VBP cord-301692-zu0ubwfq 39 17 not not RB cord-301692-zu0ubwfq 39 18 correlate correlate VB cord-301692-zu0ubwfq 39 19 with with IN cord-301692-zu0ubwfq 39 20 protection protection NN cord-301692-zu0ubwfq 39 21 . . . cord-301692-zu0ubwfq 40 1 NAs na NNS cord-301692-zu0ubwfq 40 2 are be VBP cord-301692-zu0ubwfq 40 3 not not RB cord-301692-zu0ubwfq 40 4 detected detect VBN cord-301692-zu0ubwfq 40 5 by by IN cord-301692-zu0ubwfq 40 6 conventional conventional JJ cord-301692-zu0ubwfq 40 7 virus virus NN cord-301692-zu0ubwfq 40 8 neutralisation neutralisation NN cord-301692-zu0ubwfq 40 9 tests test NNS cord-301692-zu0ubwfq 40 10 ( ( -LRB- cord-301692-zu0ubwfq 40 11 VNTs VNTs NNP cord-301692-zu0ubwfq 40 12 ) ) -RRB- cord-301692-zu0ubwfq 40 13 in in IN cord-301692-zu0ubwfq 40 14 the the DT cord-301692-zu0ubwfq 40 15 first first JJ cord-301692-zu0ubwfq 40 16 4 4 CD cord-301692-zu0ubwfq 40 17 weeks week NNS cord-301692-zu0ubwfq 40 18 PI pi NN cord-301692-zu0ubwfq 40 19 . . . cord-301692-zu0ubwfq 41 1 Addition addition NN cord-301692-zu0ubwfq 41 2 of of IN cord-301692-zu0ubwfq 41 3 fresh fresh JJ cord-301692-zu0ubwfq 41 4 complement complement NN cord-301692-zu0ubwfq 41 5 and and CC cord-301692-zu0ubwfq 41 6 prolonged prolonged JJ cord-301692-zu0ubwfq 41 7 incubation incubation NN cord-301692-zu0ubwfq 41 8 of of IN cord-301692-zu0ubwfq 41 9 virus virus NN cord-301692-zu0ubwfq 41 10 - - HYPH cord-301692-zu0ubwfq 41 11 serum serum NN cord-301692-zu0ubwfq 41 12 mixtures mixture NNS cord-301692-zu0ubwfq 41 13 increases increase VBZ cord-301692-zu0ubwfq 41 14 the the DT cord-301692-zu0ubwfq 41 15 sensitivity sensitivity NN cord-301692-zu0ubwfq 41 16 of of IN cord-301692-zu0ubwfq 41 17 the the DT cord-301692-zu0ubwfq 41 18 VNT VNT NNP cord-301692-zu0ubwfq 41 19 and and CC cord-301692-zu0ubwfq 41 20 allows allow VBZ cord-301692-zu0ubwfq 41 21 detection detection NN cord-301692-zu0ubwfq 41 22 of of IN cord-301692-zu0ubwfq 41 23 NAs NAs NNP cord-301692-zu0ubwfq 41 24 earlier early RBR cord-301692-zu0ubwfq 41 25 ( ( -LRB- cord-301692-zu0ubwfq 41 26 days day NNS cord-301692-zu0ubwfq 41 27 9 9 CD cord-301692-zu0ubwfq 41 28 - - SYM cord-301692-zu0ubwfq 41 29 12 12 CD cord-301692-zu0ubwfq 41 30 PI pi NN cord-301692-zu0ubwfq 41 31 ) ) -RRB- cord-301692-zu0ubwfq 42 1 ( ( -LRB- cord-301692-zu0ubwfq 42 2 Takikawa Takikawa NNP cord-301692-zu0ubwfq 42 3 et et NNP cord-301692-zu0ubwfq 42 4 al al NNP cord-301692-zu0ubwfq 42 5 . . NNP cord-301692-zu0ubwfq 42 6 , , , cord-301692-zu0ubwfq 42 7 1996 1996 CD cord-301692-zu0ubwfq 42 8 ) ) -RRB- cord-301692-zu0ubwfq 42 9 . . . cord-301692-zu0ubwfq 43 1 Other other JJ cord-301692-zu0ubwfq 43 2 authors author NNS cord-301692-zu0ubwfq 43 3 showed show VBD cord-301692-zu0ubwfq 43 4 that that IN cord-301692-zu0ubwfq 43 5 complement complement NN cord-301692-zu0ubwfq 43 6 may may MD cord-301692-zu0ubwfq 43 7 increase increase VB cord-301692-zu0ubwfq 43 8 VNT VNT NNP cord-301692-zu0ubwfq 43 9 titres titre NNS cord-301692-zu0ubwfq 43 10 by by IN cord-301692-zu0ubwfq 43 11 one one CD cord-301692-zu0ubwfq 43 12 dilution dilution NN cord-301692-zu0ubwfq 43 13 ( ( -LRB- cord-301692-zu0ubwfq 43 14 Diaz Diaz NNP cord-301692-zu0ubwfq 43 15 et et NNP cord-301692-zu0ubwfq 43 16 al al NNP cord-301692-zu0ubwfq 43 17 . . NNP cord-301692-zu0ubwfq 43 18 , , , cord-301692-zu0ubwfq 43 19 2005 2005 CD cord-301692-zu0ubwfq 43 20 ( ( -LRB- cord-301692-zu0ubwfq 43 21 Diaz Diaz NNP cord-301692-zu0ubwfq 43 22 et et NNP cord-301692-zu0ubwfq 43 23 al al NNP cord-301692-zu0ubwfq 43 24 . . NNP cord-301692-zu0ubwfq 43 25 , , , cord-301692-zu0ubwfq 43 26 , , , cord-301692-zu0ubwfq 43 27 2006 2006 CD cord-301692-zu0ubwfq 43 28 . . . cord-301692-zu0ubwfq 44 1 Since since IN cord-301692-zu0ubwfq 44 2 the the DT cord-301692-zu0ubwfq 44 3 addition addition NN cord-301692-zu0ubwfq 44 4 of of IN cord-301692-zu0ubwfq 44 5 2-mercaptoethanol 2-mercaptoethanol CD cord-301692-zu0ubwfq 44 6 significantly significantly RB cord-301692-zu0ubwfq 44 7 reduced reduce VBD cord-301692-zu0ubwfq 44 8 the the DT cord-301692-zu0ubwfq 44 9 sensitivity sensitivity NN cord-301692-zu0ubwfq 44 10 of of IN cord-301692-zu0ubwfq 44 11 the the DT cord-301692-zu0ubwfq 44 12 modified modify VBN cord-301692-zu0ubwfq 44 13 VNT VNT NNP cord-301692-zu0ubwfq 44 14 , , , cord-301692-zu0ubwfq 44 15 it -PRON- PRP cord-301692-zu0ubwfq 44 16 is be VBZ cord-301692-zu0ubwfq 44 17 likely likely JJ cord-301692-zu0ubwfq 44 18 that that IN cord-301692-zu0ubwfq 44 19 low low JJ cord-301692-zu0ubwfq 44 20 levels level NNS cord-301692-zu0ubwfq 44 21 of of IN cord-301692-zu0ubwfq 44 22 neutralising neutralise VBG cord-301692-zu0ubwfq 44 23 IgM IgM NNP cord-301692-zu0ubwfq 44 24 appear appear VBP cord-301692-zu0ubwfq 44 25 in in IN cord-301692-zu0ubwfq 44 26 the the DT cord-301692-zu0ubwfq 44 27 early early JJ cord-301692-zu0ubwfq 44 28 phases phase NNS cord-301692-zu0ubwfq 44 29 of of IN cord-301692-zu0ubwfq 44 30 the the DT cord-301692-zu0ubwfq 44 31 infection infection NN cord-301692-zu0ubwfq 44 32 ( ( -LRB- cord-301692-zu0ubwfq 44 33 Takikawa Takikawa NNP cord-301692-zu0ubwfq 44 34 et et NNP cord-301692-zu0ubwfq 44 35 al al NNP cord-301692-zu0ubwfq 44 36 . . NNP cord-301692-zu0ubwfq 44 37 , , , cord-301692-zu0ubwfq 44 38 1996 1996 CD cord-301692-zu0ubwfq 44 39 ) ) -RRB- cord-301692-zu0ubwfq 44 40 . . . cord-301692-zu0ubwfq 45 1 However however RB cord-301692-zu0ubwfq 45 2 , , , cord-301692-zu0ubwfq 45 3 even even RB cord-301692-zu0ubwfq 45 4 with with IN cord-301692-zu0ubwfq 45 5 this this DT cord-301692-zu0ubwfq 45 6 modified modify VBN cord-301692-zu0ubwfq 45 7 VNT VNT NNP cord-301692-zu0ubwfq 45 8 , , , cord-301692-zu0ubwfq 45 9 NA NA NNP cord-301692-zu0ubwfq 45 10 titres titre NNS cord-301692-zu0ubwfq 45 11 were be VBD cord-301692-zu0ubwfq 45 12 still still RB cord-301692-zu0ubwfq 45 13 relatively relatively RB cord-301692-zu0ubwfq 45 14 low low JJ cord-301692-zu0ubwfq 45 15 ( ( -LRB- cord-301692-zu0ubwfq 45 16 1/32 1/32 CD cord-301692-zu0ubwfq 45 17 - - HYPH cord-301692-zu0ubwfq 45 18 1/64 1/64 CD cord-301692-zu0ubwfq 45 19 ) ) -RRB- cord-301692-zu0ubwfq 45 20 by by IN cord-301692-zu0ubwfq 45 21 day day NN cord-301692-zu0ubwfq 45 22 42 42 CD cord-301692-zu0ubwfq 45 23 PI pi NN cord-301692-zu0ubwfq 45 24 . . . cord-301692-zu0ubwfq 46 1 NAs na NNS cord-301692-zu0ubwfq 46 2 are be VBP cord-301692-zu0ubwfq 46 3 consistently consistently RB cord-301692-zu0ubwfq 46 4 detected detect VBN cord-301692-zu0ubwfq 46 5 by by IN cord-301692-zu0ubwfq 46 6 day day NN cord-301692-zu0ubwfq 46 7 28 28 CD cord-301692-zu0ubwfq 46 8 PI pi NN cord-301692-zu0ubwfq 46 9 or or CC cord-301692-zu0ubwfq 46 10 later later RB cord-301692-zu0ubwfq 46 11 for for IN cord-301692-zu0ubwfq 46 12 both both CC cord-301692-zu0ubwfq 46 13 European european JJ cord-301692-zu0ubwfq 46 14 and and CC cord-301692-zu0ubwfq 46 15 American american JJ cord-301692-zu0ubwfq 46 16 - - HYPH cord-301692-zu0ubwfq 46 17 type type NN cord-301692-zu0ubwfq 46 18 strains strain NNS cord-301692-zu0ubwfq 46 19 of of IN cord-301692-zu0ubwfq 46 20 PRRSV PRRSV NNP cord-301692-zu0ubwfq 47 1 ( ( -LRB- cord-301692-zu0ubwfq 47 2 Yoon Yoon NNP cord-301692-zu0ubwfq 47 3 et et FW cord-301692-zu0ubwfq 47 4 al al NNP cord-301692-zu0ubwfq 47 5 . . . cord-301692-zu0ubwfq 48 1 , , , cord-301692-zu0ubwfq 48 2 1994 1994 CD cord-301692-zu0ubwfq 48 3 ; ; : cord-301692-zu0ubwfq 48 4 Meier Meier NNP cord-301692-zu0ubwfq 48 5 et et NNP cord-301692-zu0ubwfq 48 6 al al NNP cord-301692-zu0ubwfq 48 7 . . NNP cord-301692-zu0ubwfq 48 8 , , , cord-301692-zu0ubwfq 48 9 2003 2003 CD cord-301692-zu0ubwfq 48 10 ; ; : cord-301692-zu0ubwfq 48 11 Diaz Diaz NNP cord-301692-zu0ubwfq 48 12 et et NNP cord-301692-zu0ubwfq 48 13 al al NNP cord-301692-zu0ubwfq 48 14 . . NNP cord-301692-zu0ubwfq 48 15 , , , cord-301692-zu0ubwfq 48 16 2005 2005 CD cord-301692-zu0ubwfq 48 17 ) ) -RRB- cord-301692-zu0ubwfq 48 18 . . . cord-301692-zu0ubwfq 49 1 These these DT cord-301692-zu0ubwfq 49 2 NAs na NNS cord-301692-zu0ubwfq 49 3 are be VBP cord-301692-zu0ubwfq 49 4 mainly mainly RB cord-301692-zu0ubwfq 49 5 directed direct VBN cord-301692-zu0ubwfq 49 6 against against IN cord-301692-zu0ubwfq 49 7 GP5 GP5 NNP cord-301692-zu0ubwfq 49 8 , , , cord-301692-zu0ubwfq 49 9 which which WDT cord-301692-zu0ubwfq 49 10 contains contain VBZ cord-301692-zu0ubwfq 49 11 the the DT cord-301692-zu0ubwfq 49 12 major major JJ cord-301692-zu0ubwfq 49 13 neutralisation neutralisation NN cord-301692-zu0ubwfq 49 14 epitope epitope NN cord-301692-zu0ubwfq 49 15 ( ( -LRB- cord-301692-zu0ubwfq 49 16 Nelson Nelson NNP cord-301692-zu0ubwfq 49 17 et et NNP cord-301692-zu0ubwfq 49 18 al al NNP cord-301692-zu0ubwfq 49 19 . . NNP cord-301692-zu0ubwfq 49 20 , , , cord-301692-zu0ubwfq 49 21 1994 1994 CD cord-301692-zu0ubwfq 49 22 ; ; : cord-301692-zu0ubwfq 49 23 Dea Dea NNP cord-301692-zu0ubwfq 49 24 , , , cord-301692-zu0ubwfq 49 25 1997 1997 CD cord-301692-zu0ubwfq 49 26 , , , cord-301692-zu0ubwfq 49 27 1998 1998 CD cord-301692-zu0ubwfq 49 28 ; ; : cord-301692-zu0ubwfq 49 29 Gonin Gonin NNP cord-301692-zu0ubwfq 49 30 et et NNP cord-301692-zu0ubwfq 49 31 al al NNP cord-301692-zu0ubwfq 49 32 . . NNP cord-301692-zu0ubwfq 49 33 , , , cord-301692-zu0ubwfq 49 34 1999 1999 CD cord-301692-zu0ubwfq 49 35 ) ) -RRB- cord-301692-zu0ubwfq 49 36 . . . cord-301692-zu0ubwfq 50 1 It -PRON- PRP cord-301692-zu0ubwfq 50 2 has have VBZ cord-301692-zu0ubwfq 50 3 been be VBN cord-301692-zu0ubwfq 50 4 claimed claim VBN cord-301692-zu0ubwfq 50 5 that that IN cord-301692-zu0ubwfq 50 6 GP4 GP4 NNP cord-301692-zu0ubwfq 50 7 and and CC cord-301692-zu0ubwfq 50 8 M M NNP cord-301692-zu0ubwfq 50 9 proteins protein NNS cord-301692-zu0ubwfq 50 10 also also RB cord-301692-zu0ubwfq 50 11 contain contain VBP cord-301692-zu0ubwfq 50 12 neutralising neutralise VBG cord-301692-zu0ubwfq 50 13 epitopes epitope NNS cord-301692-zu0ubwfq 50 14 ( ( -LRB- cord-301692-zu0ubwfq 50 15 Meulenberg Meulenberg NNP cord-301692-zu0ubwfq 50 16 et et NNP cord-301692-zu0ubwfq 50 17 al al NNP cord-301692-zu0ubwfq 50 18 . . NNP cord-301692-zu0ubwfq 50 19 , , , cord-301692-zu0ubwfq 50 20 1997 1997 CD cord-301692-zu0ubwfq 50 21 ; ; . cord-301692-zu0ubwfq 51 1 Gonin Gonin NNP cord-301692-zu0ubwfq 51 2 et et NNP cord-301692-zu0ubwfq 51 3 al al NNP cord-301692-zu0ubwfq 51 4 . . . cord-301692-zu0ubwfq 52 1 , , , cord-301692-zu0ubwfq 52 2 1999 1999 CD cord-301692-zu0ubwfq 52 3 ; ; : cord-301692-zu0ubwfq 52 4 Weiland Weiland NNP cord-301692-zu0ubwfq 52 5 et et NNP cord-301692-zu0ubwfq 52 6 al al NNP cord-301692-zu0ubwfq 52 7 . . NNP cord-301692-zu0ubwfq 52 8 , , , cord-301692-zu0ubwfq 52 9 1999 1999 CD cord-301692-zu0ubwfq 53 1 ; ; : cord-301692-zu0ubwfq 53 2 Yang Yang NNP cord-301692-zu0ubwfq 53 3 et et NNP cord-301692-zu0ubwfq 53 4 al al NNP cord-301692-zu0ubwfq 53 5 . . NNP cord-301692-zu0ubwfq 53 6 , , , cord-301692-zu0ubwfq 53 7 2000 2000 CD cord-301692-zu0ubwfq 54 1 ; ; : cord-301692-zu0ubwfq 54 2 Cancel cancel VB cord-301692-zu0ubwfq 54 3 - - HYPH cord-301692-zu0ubwfq 54 4 Tirado Tirado NNP cord-301692-zu0ubwfq 54 5 et et FW cord-301692-zu0ubwfq 54 6 al al NNP cord-301692-zu0ubwfq 54 7 . . NNP cord-301692-zu0ubwfq 54 8 , , , cord-301692-zu0ubwfq 54 9 2004 2004 CD cord-301692-zu0ubwfq 54 10 ) ) -RRB- cord-301692-zu0ubwfq 54 11 and and CC cord-301692-zu0ubwfq 54 12 one one CD cord-301692-zu0ubwfq 54 13 report report NN cord-301692-zu0ubwfq 54 14 suggested suggest VBD cord-301692-zu0ubwfq 54 15 that that IN cord-301692-zu0ubwfq 54 16 GP3 GP3 NNP cord-301692-zu0ubwfq 54 17 also also RB cord-301692-zu0ubwfq 54 18 contains contain VBZ cord-301692-zu0ubwfq 54 19 a a DT cord-301692-zu0ubwfq 54 20 neutralising neutralise VBG cord-301692-zu0ubwfq 54 21 epitope epitope NN cord-301692-zu0ubwfq 54 22 ( ( -LRB- cord-301692-zu0ubwfq 54 23 Cancel cancel VB cord-301692-zu0ubwfq 54 24 - - HYPH cord-301692-zu0ubwfq 54 25 Tirado Tirado NNP cord-301692-zu0ubwfq 54 26 et et FW cord-301692-zu0ubwfq 54 27 al al NNP cord-301692-zu0ubwfq 54 28 . . NNP cord-301692-zu0ubwfq 54 29 , , , cord-301692-zu0ubwfq 54 30 2004 2004 CD cord-301692-zu0ubwfq 54 31 ) ) -RRB- cord-301692-zu0ubwfq 54 32 . . . cord-301692-zu0ubwfq 55 1 However however RB cord-301692-zu0ubwfq 55 2 , , , cord-301692-zu0ubwfq 55 3 these these DT cord-301692-zu0ubwfq 55 4 proteins protein NNS cord-301692-zu0ubwfq 55 5 seem seem VBP cord-301692-zu0ubwfq 55 6 to to TO cord-301692-zu0ubwfq 55 7 be be VB cord-301692-zu0ubwfq 55 8 of of IN cord-301692-zu0ubwfq 55 9 minor minor JJ cord-301692-zu0ubwfq 55 10 biological biological JJ cord-301692-zu0ubwfq 55 11 significance significance NN cord-301692-zu0ubwfq 55 12 compared compare VBN cord-301692-zu0ubwfq 55 13 to to IN cord-301692-zu0ubwfq 55 14 GP5 GP5 NNP cord-301692-zu0ubwfq 55 15 . . . cord-301692-zu0ubwfq 56 1 The the DT cord-301692-zu0ubwfq 56 2 early early JJ cord-301692-zu0ubwfq 56 3 development development NN cord-301692-zu0ubwfq 56 4 of of IN cord-301692-zu0ubwfq 56 5 non non JJ cord-301692-zu0ubwfq 56 6 - - NNS cord-301692-zu0ubwfq 56 7 NAs NAs NNPS cord-301692-zu0ubwfq 56 8 may may MD cord-301692-zu0ubwfq 56 9 have have VB cord-301692-zu0ubwfq 56 10 a a DT cord-301692-zu0ubwfq 56 11 significant significant JJ cord-301692-zu0ubwfq 56 12 effect effect NN cord-301692-zu0ubwfq 56 13 on on IN cord-301692-zu0ubwfq 56 14 the the DT cord-301692-zu0ubwfq 56 15 development development NN cord-301692-zu0ubwfq 56 16 of of IN cord-301692-zu0ubwfq 56 17 PRRS PRRS NNP cord-301692-zu0ubwfq 56 18 . . . cord-301692-zu0ubwfq 57 1 It -PRON- PRP cord-301692-zu0ubwfq 57 2 has have VBZ cord-301692-zu0ubwfq 57 3 been be VBN cord-301692-zu0ubwfq 57 4 shown show VBN cord-301692-zu0ubwfq 57 5 that that IN cord-301692-zu0ubwfq 57 6 non non JJ cord-301692-zu0ubwfq 57 7 - - JJ cord-301692-zu0ubwfq 57 8 NAs NAs NNPS cord-301692-zu0ubwfq 57 9 enhance enhance VB cord-301692-zu0ubwfq 57 10 viral viral JJ cord-301692-zu0ubwfq 57 11 replication replication NN cord-301692-zu0ubwfq 57 12 in in IN cord-301692-zu0ubwfq 57 13 alveolar alveolar JJ cord-301692-zu0ubwfq 57 14 macrophages macrophage NNS cord-301692-zu0ubwfq 57 15 , , , cord-301692-zu0ubwfq 57 16 a a DT cord-301692-zu0ubwfq 57 17 phenomenon phenomenon NN cord-301692-zu0ubwfq 57 18 known know VBN cord-301692-zu0ubwfq 57 19 as as IN cord-301692-zu0ubwfq 57 20 antibodydependent antibodydependent NN cord-301692-zu0ubwfq 57 21 enhancement enhancement NN cord-301692-zu0ubwfq 57 22 ( ( -LRB- cord-301692-zu0ubwfq 57 23 ADE ADE NNP cord-301692-zu0ubwfq 57 24 ) ) -RRB- cord-301692-zu0ubwfq 58 1 ( ( -LRB- cord-301692-zu0ubwfq 58 2 Yoon Yoon NNP cord-301692-zu0ubwfq 58 3 et et FW cord-301692-zu0ubwfq 58 4 al al NNP cord-301692-zu0ubwfq 58 5 . . . cord-301692-zu0ubwfq 59 1 , , , cord-301692-zu0ubwfq 59 2 1996 1996 CD cord-301692-zu0ubwfq 60 1 ( ( -LRB- cord-301692-zu0ubwfq 60 2 Yoon Yoon NNP cord-301692-zu0ubwfq 60 3 et et FW cord-301692-zu0ubwfq 60 4 al al NNP cord-301692-zu0ubwfq 60 5 . . NNP cord-301692-zu0ubwfq 60 6 , , , cord-301692-zu0ubwfq 60 7 , , , cord-301692-zu0ubwfq 60 8 1997 1997 CD cord-301692-zu0ubwfq 60 9 . . . cord-301692-zu0ubwfq 61 1 Targets target NNS cord-301692-zu0ubwfq 61 2 for for IN cord-301692-zu0ubwfq 61 3 these these DT cord-301692-zu0ubwfq 61 4 antibodies antibody NNS cord-301692-zu0ubwfq 61 5 are be VBP cord-301692-zu0ubwfq 61 6 GP5 GP5 NNP cord-301692-zu0ubwfq 61 7 and and CC cord-301692-zu0ubwfq 61 8 N n CD cord-301692-zu0ubwfq 61 9 proteins protein NNS cord-301692-zu0ubwfq 62 1 ( ( -LRB- cord-301692-zu0ubwfq 62 2 Yoon Yoon NNP cord-301692-zu0ubwfq 62 3 et et FW cord-301692-zu0ubwfq 62 4 al al NNP cord-301692-zu0ubwfq 62 5 . . . cord-301692-zu0ubwfq 63 1 , , , cord-301692-zu0ubwfq 63 2 1996 1996 CD cord-301692-zu0ubwfq 63 3 ; ; : cord-301692-zu0ubwfq 63 4 Cancel cancel VB cord-301692-zu0ubwfq 63 5 - - HYPH cord-301692-zu0ubwfq 63 6 Tirado Tirado NNP cord-301692-zu0ubwfq 63 7 et et FW cord-301692-zu0ubwfq 63 8 al al NNP cord-301692-zu0ubwfq 63 9 . . NNP cord-301692-zu0ubwfq 63 10 , , , cord-301692-zu0ubwfq 63 11 2004 2004 CD cord-301692-zu0ubwfq 63 12 ) ) -RRB- cord-301692-zu0ubwfq 63 13 . . . cord-301692-zu0ubwfq 64 1 The the DT cord-301692-zu0ubwfq 64 2 non non JJ cord-301692-zu0ubwfq 64 3 - - JJ cord-301692-zu0ubwfq 64 4 neutralising neutralise VBG cord-301692-zu0ubwfq 64 5 humoral humoral JJ cord-301692-zu0ubwfq 64 6 response response NN cord-301692-zu0ubwfq 64 7 may may MD cord-301692-zu0ubwfq 64 8 act act VB cord-301692-zu0ubwfq 64 9 as as IN cord-301692-zu0ubwfq 64 10 a a DT cord-301692-zu0ubwfq 64 11 Trojan Trojan NNP cord-301692-zu0ubwfq 64 12 horse horse NN cord-301692-zu0ubwfq 64 13 for for IN cord-301692-zu0ubwfq 64 14 PRRSV PRRSV NNP cord-301692-zu0ubwfq 64 15 by by IN cord-301692-zu0ubwfq 64 16 coating coat VBG cord-301692-zu0ubwfq 64 17 the the DT cord-301692-zu0ubwfq 64 18 virus virus NN cord-301692-zu0ubwfq 64 19 and and CC cord-301692-zu0ubwfq 64 20 enhancing enhance VBG cord-301692-zu0ubwfq 64 21 the the DT cord-301692-zu0ubwfq 64 22 internalisation internalisation NN cord-301692-zu0ubwfq 64 23 of of IN cord-301692-zu0ubwfq 64 24 viral viral JJ cord-301692-zu0ubwfq 64 25 particles particle NNS cord-301692-zu0ubwfq 64 26 into into IN cord-301692-zu0ubwfq 64 27 macrophages macrophage NNS cord-301692-zu0ubwfq 64 28 . . . cord-301692-zu0ubwfq 65 1 The the DT cord-301692-zu0ubwfq 65 2 question question NN cord-301692-zu0ubwfq 65 3 is be VBZ cord-301692-zu0ubwfq 65 4 : : : cord-301692-zu0ubwfq 65 5 why why WRB cord-301692-zu0ubwfq 65 6 NAs na NNS cord-301692-zu0ubwfq 65 7 do do VBP cord-301692-zu0ubwfq 65 8 not not RB cord-301692-zu0ubwfq 65 9 develop develop VB cord-301692-zu0ubwfq 65 10 as as RB cord-301692-zu0ubwfq 65 11 early early RB cord-301692-zu0ubwfq 65 12 as as IN cord-301692-zu0ubwfq 65 13 non non JJ cord-301692-zu0ubwfq 65 14 - - JJ cord-301692-zu0ubwfq 65 15 NAs nas JJ cord-301692-zu0ubwfq 65 16 ? ? . cord-301692-zu0ubwfq 66 1 NAs NAs NNP cord-301692-zu0ubwfq 66 2 may may MD cord-301692-zu0ubwfq 66 3 play play VB cord-301692-zu0ubwfq 66 4 an an DT cord-301692-zu0ubwfq 66 5 important important JJ cord-301692-zu0ubwfq 66 6 role role NN cord-301692-zu0ubwfq 66 7 , , , cord-301692-zu0ubwfq 66 8 although although IN cord-301692-zu0ubwfq 66 9 their -PRON- PRP$ cord-301692-zu0ubwfq 66 10 importance importance NN cord-301692-zu0ubwfq 66 11 may may MD cord-301692-zu0ubwfq 66 12 be be VB cord-301692-zu0ubwfq 66 13 different different JJ cord-301692-zu0ubwfq 66 14 in in IN cord-301692-zu0ubwfq 66 15 natural natural JJ cord-301692-zu0ubwfq 66 16 infection infection NN cord-301692-zu0ubwfq 66 17 compared compare VBN cord-301692-zu0ubwfq 66 18 to to IN cord-301692-zu0ubwfq 66 19 vaccination vaccination NN cord-301692-zu0ubwfq 66 20 . . . cord-301692-zu0ubwfq 67 1 Vezina Vezina NNP cord-301692-zu0ubwfq 67 2 et et NNP cord-301692-zu0ubwfq 67 3 al al NNP cord-301692-zu0ubwfq 67 4 . . . cord-301692-zu0ubwfq 68 1 ( ( -LRB- cord-301692-zu0ubwfq 68 2 1996 1996 CD cord-301692-zu0ubwfq 68 3 ) ) -RRB- cord-301692-zu0ubwfq 68 4 reported report VBD cord-301692-zu0ubwfq 68 5 the the DT cord-301692-zu0ubwfq 68 6 isolation isolation NN cord-301692-zu0ubwfq 68 7 of of IN cord-301692-zu0ubwfq 68 8 PRRSV PRRSV NNP cord-301692-zu0ubwfq 68 9 from from IN cord-301692-zu0ubwfq 68 10 the the DT cord-301692-zu0ubwfq 68 11 blood blood NN cord-301692-zu0ubwfq 68 12 of of IN cord-301692-zu0ubwfq 68 13 pigs pig NNS cord-301692-zu0ubwfq 68 14 with with IN cord-301692-zu0ubwfq 68 15 NAs na NNS cord-301692-zu0ubwfq 68 16 . . . cord-301692-zu0ubwfq 69 1 Following follow VBG cord-301692-zu0ubwfq 69 2 experimental experimental JJ cord-301692-zu0ubwfq 69 3 infection infection NN cord-301692-zu0ubwfq 69 4 , , , cord-301692-zu0ubwfq 69 5 viraemia viraemia NN cord-301692-zu0ubwfq 69 6 may may MD cord-301692-zu0ubwfq 69 7 be be VB cord-301692-zu0ubwfq 69 8 resolved resolve VBN cord-301692-zu0ubwfq 69 9 without without IN cord-301692-zu0ubwfq 69 10 detectable detectable JJ cord-301692-zu0ubwfq 69 11 levels level NNS cord-301692-zu0ubwfq 69 12 of of IN cord-301692-zu0ubwfq 69 13 neutralising neutralise VBG cord-301692-zu0ubwfq 69 14 antibodies antibody NNS cord-301692-zu0ubwfq 69 15 ( ( -LRB- cord-301692-zu0ubwfq 69 16 Diaz Diaz NNP cord-301692-zu0ubwfq 69 17 et et NNP cord-301692-zu0ubwfq 69 18 al al NNP cord-301692-zu0ubwfq 69 19 . . NNP cord-301692-zu0ubwfq 69 20 , , , cord-301692-zu0ubwfq 69 21 2006 2006 CD cord-301692-zu0ubwfq 69 22 ) ) -RRB- cord-301692-zu0ubwfq 69 23 . . . cord-301692-zu0ubwfq 70 1 Similar similar JJ cord-301692-zu0ubwfq 70 2 to to IN cord-301692-zu0ubwfq 70 3 the the DT cord-301692-zu0ubwfq 70 4 related related JJ cord-301692-zu0ubwfq 70 5 virus virus NN cord-301692-zu0ubwfq 70 6 lactate lactate NN cord-301692-zu0ubwfq 70 7 dehydrogenase dehydrogenase NN cord-301692-zu0ubwfq 70 8 virus virus NN cord-301692-zu0ubwfq 70 9 ( ( -LRB- cord-301692-zu0ubwfq 70 10 LDV LDV NNP cord-301692-zu0ubwfq 70 11 ) ) -RRB- cord-301692-zu0ubwfq 70 12 , , , cord-301692-zu0ubwfq 70 13 the the DT cord-301692-zu0ubwfq 70 14 dynamics dynamic NNS cord-301692-zu0ubwfq 70 15 of of IN cord-301692-zu0ubwfq 70 16 PRRSV PRRSV NNP cord-301692-zu0ubwfq 70 17 - - HYPH cord-301692-zu0ubwfq 70 18 susceptible susceptible JJ cord-301692-zu0ubwfq 70 19 macrophages macrophage NNS cord-301692-zu0ubwfq 70 20 may may MD cord-301692-zu0ubwfq 70 21 govern govern VB cord-301692-zu0ubwfq 70 22 the the DT cord-301692-zu0ubwfq 70 23 levels level NNS cord-301692-zu0ubwfq 70 24 of of IN cord-301692-zu0ubwfq 70 25 viraemia viraemia NN cord-301692-zu0ubwfq 71 1 ( ( -LRB- cord-301692-zu0ubwfq 71 2 Diaz Diaz NNP cord-301692-zu0ubwfq 71 3 et et NNP cord-301692-zu0ubwfq 71 4 al al NNP cord-301692-zu0ubwfq 71 5 . . NNP cord-301692-zu0ubwfq 71 6 , , , cord-301692-zu0ubwfq 71 7 2006 2006 CD cord-301692-zu0ubwfq 71 8 ) ) -RRB- cord-301692-zu0ubwfq 71 9 . . . cord-301692-zu0ubwfq 72 1 If if IN cord-301692-zu0ubwfq 72 2 cytolysis cytolysis NN cord-301692-zu0ubwfq 72 3 or or CC cord-301692-zu0ubwfq 72 4 apoptosis apoptosis NN cord-301692-zu0ubwfq 72 5 exhaust exhaust NN cord-301692-zu0ubwfq 72 6 most most RBS cord-301692-zu0ubwfq 72 7 susceptible susceptible JJ cord-301692-zu0ubwfq 72 8 macrophages macrophage NNS cord-301692-zu0ubwfq 72 9 , , , cord-301692-zu0ubwfq 72 10 infection infection NN cord-301692-zu0ubwfq 72 11 will will MD cord-301692-zu0ubwfq 72 12 be be VB cord-301692-zu0ubwfq 72 13 confined confine VBN cord-301692-zu0ubwfq 72 14 to to IN cord-301692-zu0ubwfq 72 15 macrophage macrophage NN cord-301692-zu0ubwfq 72 16 - - HYPH cord-301692-zu0ubwfq 72 17 rich rich JJ cord-301692-zu0ubwfq 72 18 organs organ NNS cord-301692-zu0ubwfq 72 19 , , , cord-301692-zu0ubwfq 72 20 such such JJ cord-301692-zu0ubwfq 72 21 as as IN cord-301692-zu0ubwfq 72 22 lymph lymph NN cord-301692-zu0ubwfq 72 23 nodes node NNS cord-301692-zu0ubwfq 72 24 . . . cord-301692-zu0ubwfq 73 1 In in IN cord-301692-zu0ubwfq 73 2 this this DT cord-301692-zu0ubwfq 73 3 hypothesis hypothesis NN cord-301692-zu0ubwfq 73 4 , , , cord-301692-zu0ubwfq 73 5 NAs NAs NNP cord-301692-zu0ubwfq 73 6 may may MD cord-301692-zu0ubwfq 73 7 be be VB cord-301692-zu0ubwfq 73 8 required require VBN cord-301692-zu0ubwfq 73 9 for for IN cord-301692-zu0ubwfq 73 10 resolution resolution NN cord-301692-zu0ubwfq 73 11 of of IN cord-301692-zu0ubwfq 73 12 viraemia viraemia NN cord-301692-zu0ubwfq 73 13 , , , cord-301692-zu0ubwfq 73 14 if if IN cord-301692-zu0ubwfq 73 15 not not RB cord-301692-zu0ubwfq 73 16 infection infection NN cord-301692-zu0ubwfq 73 17 . . . cord-301692-zu0ubwfq 74 1 A a DT cord-301692-zu0ubwfq 74 2 different different JJ cord-301692-zu0ubwfq 74 3 picture picture NN cord-301692-zu0ubwfq 74 4 arises arise VBZ cord-301692-zu0ubwfq 74 5 when when WRB cord-301692-zu0ubwfq 74 6 protection protection NN cord-301692-zu0ubwfq 74 7 before before IN cord-301692-zu0ubwfq 74 8 infection infection NN cord-301692-zu0ubwfq 74 9 is be VBZ cord-301692-zu0ubwfq 74 10 considered consider VBN cord-301692-zu0ubwfq 74 11 . . . cord-301692-zu0ubwfq 75 1 NAs NAs NNPS cord-301692-zu0ubwfq 75 2 block block VBP cord-301692-zu0ubwfq 75 3 PRRSV PRRSV NNP cord-301692-zu0ubwfq 75 4 infectivity infectivity NN cord-301692-zu0ubwfq 75 5 for for IN cord-301692-zu0ubwfq 75 6 macrophages macrophage NNS cord-301692-zu0ubwfq 75 7 in in IN cord-301692-zu0ubwfq 75 8 vitro vitro FW cord-301692-zu0ubwfq 75 9 ( ( -LRB- cord-301692-zu0ubwfq 76 1 Delputte Delputte NNP cord-301692-zu0ubwfq 76 2 et et FW cord-301692-zu0ubwfq 76 3 al al NNP cord-301692-zu0ubwfq 76 4 . . NNP cord-301692-zu0ubwfq 76 5 , , , cord-301692-zu0ubwfq 76 6 2004 2004 CD cord-301692-zu0ubwfq 76 7 ) ) -RRB- cord-301692-zu0ubwfq 76 8 . . . cord-301692-zu0ubwfq 77 1 Transfer transfer NN cord-301692-zu0ubwfq 77 2 of of IN cord-301692-zu0ubwfq 77 3 NAs na NNS cord-301692-zu0ubwfq 77 4 to to IN cord-301692-zu0ubwfq 77 5 pregnant pregnant JJ cord-301692-zu0ubwfq 77 6 sows sow NNS cord-301692-zu0ubwfq 77 7 ( ( -LRB- cord-301692-zu0ubwfq 77 8 NA NA NNP cord-301692-zu0ubwfq 77 9 titres titre NNS cord-301692-zu0ubwfq 77 10 1/16 1/16 CD cord-301692-zu0ubwfq 77 11 ) ) -RRB- cord-301692-zu0ubwfq 77 12 protects protect VBZ cord-301692-zu0ubwfq 77 13 them -PRON- PRP cord-301692-zu0ubwfq 77 14 against against IN cord-301692-zu0ubwfq 77 15 reproductive reproductive JJ cord-301692-zu0ubwfq 77 16 failure failure NN cord-301692-zu0ubwfq 77 17 and and CC cord-301692-zu0ubwfq 77 18 blocks block VBZ cord-301692-zu0ubwfq 77 19 transplacental transplacental JJ cord-301692-zu0ubwfq 77 20 infection infection NN cord-301692-zu0ubwfq 77 21 . . . cord-301692-zu0ubwfq 78 1 Using use VBG cord-301692-zu0ubwfq 78 2 the the DT cord-301692-zu0ubwfq 78 3 same same JJ cord-301692-zu0ubwfq 78 4 antibody antibody NN cord-301692-zu0ubwfq 78 5 transfer transfer NN cord-301692-zu0ubwfq 78 6 system system NN cord-301692-zu0ubwfq 78 7 , , , cord-301692-zu0ubwfq 78 8 a a DT cord-301692-zu0ubwfq 78 9 titre titre NN cord-301692-zu0ubwfq 78 10 of of IN cord-301692-zu0ubwfq 78 11 1/8 1/8 CD cord-301692-zu0ubwfq 78 12 or or CC cord-301692-zu0ubwfq 78 13 higher high JJR cord-301692-zu0ubwfq 78 14 protected protect VBN cord-301692-zu0ubwfq 78 15 piglets piglet NNS cord-301692-zu0ubwfq 78 16 against against IN cord-301692-zu0ubwfq 78 17 the the DT cord-301692-zu0ubwfq 78 18 development development NN cord-301692-zu0ubwfq 78 19 of of IN cord-301692-zu0ubwfq 78 20 viraemia viraemia NN cord-301692-zu0ubwfq 78 21 , , , cord-301692-zu0ubwfq 78 22 whereas whereas IN cord-301692-zu0ubwfq 78 23 sterilising sterilise VBG cord-301692-zu0ubwfq 78 24 immunity immunity NN cord-301692-zu0ubwfq 78 25 was be VBD cord-301692-zu0ubwfq 78 26 attained attain VBN cord-301692-zu0ubwfq 78 27 at at IN cord-301692-zu0ubwfq 78 28 NA NA NNP cord-301692-zu0ubwfq 78 29 titres titre NNS cord-301692-zu0ubwfq 78 30 of of IN cord-301692-zu0ubwfq 78 31 1/32 1/32 CD cord-301692-zu0ubwfq 78 32 ( ( -LRB- cord-301692-zu0ubwfq 78 33 Lopez Lopez NNP cord-301692-zu0ubwfq 78 34 et et NNP cord-301692-zu0ubwfq 78 35 al al NNP cord-301692-zu0ubwfq 78 36 . . NNP cord-301692-zu0ubwfq 78 37 , , , cord-301692-zu0ubwfq 78 38 2007 2007 CD cord-301692-zu0ubwfq 78 39 ) ) -RRB- cord-301692-zu0ubwfq 78 40 . . . cord-301692-zu0ubwfq 79 1 These these DT cord-301692-zu0ubwfq 79 2 results result NNS cord-301692-zu0ubwfq 79 3 suggest suggest VBP cord-301692-zu0ubwfq 79 4 that that IN cord-301692-zu0ubwfq 79 5 a a DT cord-301692-zu0ubwfq 79 6 vaccine vaccine NN cord-301692-zu0ubwfq 79 7 capable capable JJ cord-301692-zu0ubwfq 79 8 of of IN cord-301692-zu0ubwfq 79 9 inducing induce VBG cord-301692-zu0ubwfq 79 10 NA NA NNP cord-301692-zu0ubwfq 79 11 titres titre NNS cord-301692-zu0ubwfq 79 12 of of IN cord-301692-zu0ubwfq 79 13 1/32 1/32 CD cord-301692-zu0ubwfq 79 14 should should MD cord-301692-zu0ubwfq 79 15 prevent prevent VB cord-301692-zu0ubwfq 79 16 clinical clinical JJ cord-301692-zu0ubwfq 79 17 disease disease NN cord-301692-zu0ubwfq 79 18 and and CC cord-301692-zu0ubwfq 79 19 be be VB cord-301692-zu0ubwfq 79 20 a a DT cord-301692-zu0ubwfq 79 21 key key JJ cord-301692-zu0ubwfq 79 22 tool tool NN cord-301692-zu0ubwfq 79 23 in in IN cord-301692-zu0ubwfq 79 24 eradication eradication NN cord-301692-zu0ubwfq 79 25 of of IN cord-301692-zu0ubwfq 79 26 PRRSV PRRSV NNP cord-301692-zu0ubwfq 79 27 . . . cord-301692-zu0ubwfq 80 1 Cell cell NN cord-301692-zu0ubwfq 80 2 - - HYPH cord-301692-zu0ubwfq 80 3 mediated mediate VBN cord-301692-zu0ubwfq 80 4 immunity immunity NN cord-301692-zu0ubwfq 80 5 ( ( -LRB- cord-301692-zu0ubwfq 80 6 CMI CMI NNP cord-301692-zu0ubwfq 80 7 ) ) -RRB- cord-301692-zu0ubwfq 80 8 is be VBZ cord-301692-zu0ubwfq 80 9 also also RB cord-301692-zu0ubwfq 80 10 extremely extremely RB cord-301692-zu0ubwfq 80 11 important important JJ cord-301692-zu0ubwfq 80 12 in in IN cord-301692-zu0ubwfq 80 13 PRRS PRRS NNP cord-301692-zu0ubwfq 80 14 . . . cord-301692-zu0ubwfq 81 1 Early early JJ cord-301692-zu0ubwfq 81 2 studies study NNS cord-301692-zu0ubwfq 81 3 showed show VBD cord-301692-zu0ubwfq 81 4 that that IN cord-301692-zu0ubwfq 81 5 pigs pig NNS cord-301692-zu0ubwfq 81 6 recovering recover VBG cord-301692-zu0ubwfq 81 7 from from IN cord-301692-zu0ubwfq 81 8 experimental experimental JJ cord-301692-zu0ubwfq 81 9 PRRSV PRRSV NNP cord-301692-zu0ubwfq 81 10 infection infection NN cord-301692-zu0ubwfq 81 11 had have VBD cord-301692-zu0ubwfq 81 12 strong strong JJ cord-301692-zu0ubwfq 81 13 lymphocyte lymphocyte NN cord-301692-zu0ubwfq 81 14 proliferative proliferative JJ cord-301692-zu0ubwfq 81 15 responses response NNS cord-301692-zu0ubwfq 81 16 , , , cord-301692-zu0ubwfq 81 17 although although IN cord-301692-zu0ubwfq 81 18 these these DT cord-301692-zu0ubwfq 81 19 responses response NNS cord-301692-zu0ubwfq 81 20 were be VBD cord-301692-zu0ubwfq 81 21 not not RB cord-301692-zu0ubwfq 81 22 detected detect VBN cord-301692-zu0ubwfq 81 23 until until IN cord-301692-zu0ubwfq 81 24 four four CD cord-301692-zu0ubwfq 81 25 weeks week NNS cord-301692-zu0ubwfq 81 26 PI pi NN cord-301692-zu0ubwfq 81 27 and and CC cord-301692-zu0ubwfq 81 28 paralleled parallel VBD cord-301692-zu0ubwfq 81 29 the the DT cord-301692-zu0ubwfq 81 30 NA NA NNP cord-301692-zu0ubwfq 81 31 response response NN cord-301692-zu0ubwfq 81 32 ( ( -LRB- cord-301692-zu0ubwfq 81 33 Bautista Bautista NNP cord-301692-zu0ubwfq 81 34 and and CC cord-301692-zu0ubwfq 81 35 Molitor Molitor NNP cord-301692-zu0ubwfq 81 36 , , , cord-301692-zu0ubwfq 81 37 1997 1997 CD cord-301692-zu0ubwfq 81 38 ; ; : cord-301692-zu0ubwfq 81 39 Lopez Lopez NNP cord-301692-zu0ubwfq 81 40 Fuertes Fuertes NNP cord-301692-zu0ubwfq 81 41 et et NNP cord-301692-zu0ubwfq 81 42 al al NNP cord-301692-zu0ubwfq 81 43 . . NNP cord-301692-zu0ubwfq 81 44 , , , cord-301692-zu0ubwfq 81 45 1999 1999 CD cord-301692-zu0ubwfq 81 46 ) ) -RRB- cord-301692-zu0ubwfq 81 47 . . . cord-301692-zu0ubwfq 82 1 Cytokine cytokine NN cord-301692-zu0ubwfq 82 2 responses response NNS cord-301692-zu0ubwfq 82 3 were be VBD cord-301692-zu0ubwfq 82 4 mainly mainly RB cord-301692-zu0ubwfq 82 5 interferon interferon JJ cord-301692-zu0ubwfq 83 1 ( ( -LRB- cord-301692-zu0ubwfq 83 2 IFN)-c IFN)-c NNP cord-301692-zu0ubwfq 83 3 and and CC cord-301692-zu0ubwfq 83 4 , , , cord-301692-zu0ubwfq 83 5 to to IN cord-301692-zu0ubwfq 83 6 a a DT cord-301692-zu0ubwfq 83 7 lesser less JJR cord-301692-zu0ubwfq 83 8 extent extent NN cord-301692-zu0ubwfq 83 9 , , , cord-301692-zu0ubwfq 83 10 IL-2 IL-2 NNP cord-301692-zu0ubwfq 83 11 ( ( -LRB- cord-301692-zu0ubwfq 83 12 Lopez Lopez NNP cord-301692-zu0ubwfq 83 13 Fuertes Fuertes NNP cord-301692-zu0ubwfq 83 14 et et NNP cord-301692-zu0ubwfq 83 15 al al NNP cord-301692-zu0ubwfq 83 16 . . NNP cord-301692-zu0ubwfq 83 17 , , , cord-301692-zu0ubwfq 83 18 1999 1999 CD cord-301692-zu0ubwfq 83 19 ) ) -RRB- cord-301692-zu0ubwfq 83 20 . . . cord-301692-zu0ubwfq 84 1 After after IN cord-301692-zu0ubwfq 84 2 vaccination vaccination NN cord-301692-zu0ubwfq 84 3 with with IN cord-301692-zu0ubwfq 84 4 a a DT cord-301692-zu0ubwfq 84 5 modified modify VBN cord-301692-zu0ubwfq 84 6 live live JJ cord-301692-zu0ubwfq 84 7 vaccine vaccine NN cord-301692-zu0ubwfq 84 8 using use VBG cord-301692-zu0ubwfq 84 9 an an DT cord-301692-zu0ubwfq 84 10 American american JJ cord-301692-zu0ubwfq 84 11 strain strain NN cord-301692-zu0ubwfq 84 12 of of IN cord-301692-zu0ubwfq 84 13 PRRSV PRRSV NNP cord-301692-zu0ubwfq 84 14 , , , cord-301692-zu0ubwfq 84 15 virus virus NN cord-301692-zu0ubwfq 84 16 - - HYPH cord-301692-zu0ubwfq 84 17 specific specific JJ cord-301692-zu0ubwfq 84 18 IFN IFN NNP cord-301692-zu0ubwfq 84 19 - - HYPH cord-301692-zu0ubwfq 84 20 c c NNP cord-301692-zu0ubwfq 84 21 secreting secreting NN cord-301692-zu0ubwfq 84 22 cells cell NNS cord-301692-zu0ubwfq 84 23 first first RB cord-301692-zu0ubwfq 84 24 appeared appear VBD cord-301692-zu0ubwfq 84 25 in in IN cord-301692-zu0ubwfq 84 26 the the DT cord-301692-zu0ubwfq 84 27 third third JJ cord-301692-zu0ubwfq 84 28 week week NN cord-301692-zu0ubwfq 84 29 post post NN cord-301692-zu0ubwfq 84 30 - - NN cord-301692-zu0ubwfq 84 31 vaccination vaccination NN cord-301692-zu0ubwfq 84 32 , , , cord-301692-zu0ubwfq 84 33 fluctuated fluctuate VBD cord-301692-zu0ubwfq 84 34 erratically erratically RB cord-301692-zu0ubwfq 84 35 from from IN cord-301692-zu0ubwfq 84 36 50 50 CD cord-301692-zu0ubwfq 84 37 - - HYPH cord-301692-zu0ubwfq 84 38 100 100 CD cord-301692-zu0ubwfq 84 39 per per IN cord-301692-zu0ubwfq 84 40 million million CD cord-301692-zu0ubwfq 84 41 peripheral peripheral JJ cord-301692-zu0ubwfq 84 42 blood blood NN cord-301692-zu0ubwfq 84 43 mononuclear mononuclear NN cord-301692-zu0ubwfq 84 44 cells cell NNS cord-301692-zu0ubwfq 84 45 ( ( -LRB- cord-301692-zu0ubwfq 84 46 PBMCs PBMCs NNP cord-301692-zu0ubwfq 84 47 ) ) -RRB- cord-301692-zu0ubwfq 84 48 for for IN cord-301692-zu0ubwfq 84 49 the the DT cord-301692-zu0ubwfq 84 50 next next JJ cord-301692-zu0ubwfq 84 51 ten ten CD cord-301692-zu0ubwfq 84 52 weeks week NNS cord-301692-zu0ubwfq 84 53 , , , cord-301692-zu0ubwfq 84 54 then then RB cord-301692-zu0ubwfq 84 55 increased increase VBD cord-301692-zu0ubwfq 84 56 to to IN cord-301692-zu0ubwfq 84 57 400 400 CD cord-301692-zu0ubwfq 84 58 - - SYM cord-301692-zu0ubwfq 84 59 500 500 CD cord-301692-zu0ubwfq 84 60 per per IN cord-301692-zu0ubwfq 84 61 million million CD cord-301692-zu0ubwfq 84 62 PBMCs pbmc NNS cord-301692-zu0ubwfq 84 63 at at IN cord-301692-zu0ubwfq 84 64 48 48 CD cord-301692-zu0ubwfq 84 65 weeks week NNS cord-301692-zu0ubwfq 84 66 post post NN cord-301692-zu0ubwfq 84 67 - - NN cord-301692-zu0ubwfq 84 68 vaccination vaccination JJ cord-301692-zu0ubwfq 85 1 ( ( -LRB- cord-301692-zu0ubwfq 85 2 Meier Meier NNP cord-301692-zu0ubwfq 85 3 et et NNP cord-301692-zu0ubwfq 85 4 al al NNP cord-301692-zu0ubwfq 85 5 . . NNP cord-301692-zu0ubwfq 85 6 , , , cord-301692-zu0ubwfq 85 7 2003 2003 CD cord-301692-zu0ubwfq 85 8 ) ) -RRB- cord-301692-zu0ubwfq 85 9 . . . cord-301692-zu0ubwfq 86 1 IFN IFN NNP cord-301692-zu0ubwfq 86 2 - - HYPH cord-301692-zu0ubwfq 86 3 c c NNP cord-301692-zu0ubwfq 86 4 secreting secreting NN cord-301692-zu0ubwfq 86 5 cells cell NNS cord-301692-zu0ubwfq 86 6 were be VBD cord-301692-zu0ubwfq 86 7 mainly mainly RB cord-301692-zu0ubwfq 86 8 CD4 CD4 NNP cord-301692-zu0ubwfq 86 9 + + SYM cord-301692-zu0ubwfq 86 10 CD8 CD8 NNP cord-301692-zu0ubwfq 86 11 + + CC cord-301692-zu0ubwfq 86 12 cells cell NNS cord-301692-zu0ubwfq 86 13 , , , cord-301692-zu0ubwfq 86 14 with with IN cord-301692-zu0ubwfq 86 15 a a DT cord-301692-zu0ubwfq 86 16 small small JJ cord-301692-zu0ubwfq 86 17 proportion proportion NN cord-301692-zu0ubwfq 86 18 of of IN cord-301692-zu0ubwfq 86 19 CD4 CD4 NNP cord-301692-zu0ubwfq 86 20 À À NNP cord-301692-zu0ubwfq 86 21 /CD8ab /CD8ab . cord-301692-zu0ubwfq 86 22 + + CC cord-301692-zu0ubwfq 86 23 cytotoxic cytotoxic JJ cord-301692-zu0ubwfq 86 24 T t NN cord-301692-zu0ubwfq 86 25 cells cell NNS cord-301692-zu0ubwfq 86 26 . . . cord-301692-zu0ubwfq 87 1 A a DT cord-301692-zu0ubwfq 87 2 similar similar JJ cord-301692-zu0ubwfq 87 3 delayed delay VBN cord-301692-zu0ubwfq 87 4 development development NN cord-301692-zu0ubwfq 87 5 of of IN cord-301692-zu0ubwfq 87 6 PRRSV PRRSV NNP cord-301692-zu0ubwfq 87 7 - - HYPH cord-301692-zu0ubwfq 87 8 specific specific JJ cord-301692-zu0ubwfq 87 9 IFN IFN NNP cord-301692-zu0ubwfq 87 10 - - HYPH cord-301692-zu0ubwfq 87 11 c c NNP cord-301692-zu0ubwfq 87 12 secreting secreting NN cord-301692-zu0ubwfq 87 13 cells cell NNS cord-301692-zu0ubwfq 87 14 was be VBD cord-301692-zu0ubwfq 87 15 evident evident JJ cord-301692-zu0ubwfq 87 16 after after IN cord-301692-zu0ubwfq 87 17 infection infection NN cord-301692-zu0ubwfq 87 18 or or CC cord-301692-zu0ubwfq 87 19 vaccination vaccination NN cord-301692-zu0ubwfq 87 20 with with IN cord-301692-zu0ubwfq 87 21 European european JJ cord-301692-zu0ubwfq 87 22 strains strain NNS cord-301692-zu0ubwfq 87 23 of of IN cord-301692-zu0ubwfq 87 24 PRRSV PRRSV NNP cord-301692-zu0ubwfq 88 1 ( ( -LRB- cord-301692-zu0ubwfq 88 2 Diaz Diaz NNP cord-301692-zu0ubwfq 88 3 et et NNP cord-301692-zu0ubwfq 88 4 al al NNP cord-301692-zu0ubwfq 88 5 . . . cord-301692-zu0ubwfq 89 1 , , , cord-301692-zu0ubwfq 89 2 2005 2005 CD cord-301692-zu0ubwfq 90 1 ( ( -LRB- cord-301692-zu0ubwfq 90 2 Diaz Diaz NNP cord-301692-zu0ubwfq 90 3 et et NNP cord-301692-zu0ubwfq 90 4 al al NNP cord-301692-zu0ubwfq 90 5 . . NNP cord-301692-zu0ubwfq 90 6 , , , cord-301692-zu0ubwfq 90 7 , , , cord-301692-zu0ubwfq 90 8 2006 2006 CD cord-301692-zu0ubwfq 90 9 . . . cord-301692-zu0ubwfq 91 1 In in IN cord-301692-zu0ubwfq 91 2 contrast contrast NN cord-301692-zu0ubwfq 91 3 , , , cord-301692-zu0ubwfq 91 4 200 200 CD cord-301692-zu0ubwfq 91 5 - - SYM cord-301692-zu0ubwfq 91 6 300 300 CD cord-301692-zu0ubwfq 91 7 IFN IFN NNP cord-301692-zu0ubwfq 91 8 - - HYPH cord-301692-zu0ubwfq 91 9 c c NNP cord-301692-zu0ubwfq 91 10 secreting secreting NN cord-301692-zu0ubwfq 91 11 cells cell NNS cord-301692-zu0ubwfq 91 12 per per IN cord-301692-zu0ubwfq 91 13 million million CD cord-301692-zu0ubwfq 91 14 PBMCs pbmc NNS cord-301692-zu0ubwfq 91 15 were be VBD cord-301692-zu0ubwfq 91 16 evident evident JJ cord-301692-zu0ubwfq 91 17 by by IN cord-301692-zu0ubwfq 91 18 3 3 CD cord-301692-zu0ubwfq 91 19 weeks week NNS cord-301692-zu0ubwfq 91 20 after after IN cord-301692-zu0ubwfq 91 21 vaccination vaccination NN cord-301692-zu0ubwfq 91 22 against against IN cord-301692-zu0ubwfq 91 23 Aujeszky Aujeszky NNP cord-301692-zu0ubwfq 91 24 's 's POS cord-301692-zu0ubwfq 91 25 disease disease NN cord-301692-zu0ubwfq 91 26 virus virus NN cord-301692-zu0ubwfq 91 27 ( ( -LRB- cord-301692-zu0ubwfq 91 28 Meier Meier NNP cord-301692-zu0ubwfq 91 29 et et NNP cord-301692-zu0ubwfq 91 30 al al NNP cord-301692-zu0ubwfq 91 31 . . NNP cord-301692-zu0ubwfq 91 32 , , , cord-301692-zu0ubwfq 91 33 2003 2003 CD cord-301692-zu0ubwfq 91 34 ) ) -RRB- cord-301692-zu0ubwfq 91 35 . . . cord-301692-zu0ubwfq 92 1 The the DT cord-301692-zu0ubwfq 92 2 unusual unusual JJ cord-301692-zu0ubwfq 92 3 characteristics characteristic NNS cord-301692-zu0ubwfq 92 4 of of IN cord-301692-zu0ubwfq 92 5 the the DT cord-301692-zu0ubwfq 92 6 adaptive adaptive JJ cord-301692-zu0ubwfq 92 7 immune immune JJ cord-301692-zu0ubwfq 92 8 response response NN cord-301692-zu0ubwfq 92 9 to to IN cord-301692-zu0ubwfq 92 10 PRRSV PRRSV NNP cord-301692-zu0ubwfq 92 11 suggest suggest VBP cord-301692-zu0ubwfq 92 12 that that IN cord-301692-zu0ubwfq 92 13 the the DT cord-301692-zu0ubwfq 92 14 virus virus NN cord-301692-zu0ubwfq 92 15 strongly strongly RB cord-301692-zu0ubwfq 92 16 modulates modulate VBZ cord-301692-zu0ubwfq 92 17 the the DT cord-301692-zu0ubwfq 92 18 immune immune JJ cord-301692-zu0ubwfq 92 19 response response NN cord-301692-zu0ubwfq 92 20 . . . cord-301692-zu0ubwfq 93 1 Early early JJ cord-301692-zu0ubwfq 93 2 studies study NNS cord-301692-zu0ubwfq 93 3 showed show VBD cord-301692-zu0ubwfq 93 4 that that IN cord-301692-zu0ubwfq 93 5 PRRSV PRRSV NNP cord-301692-zu0ubwfq 93 6 is be VBZ cord-301692-zu0ubwfq 93 7 highly highly RB cord-301692-zu0ubwfq 93 8 susceptible susceptible JJ cord-301692-zu0ubwfq 93 9 to to IN cord-301692-zu0ubwfq 93 10 the the DT cord-301692-zu0ubwfq 93 11 action action NN cord-301692-zu0ubwfq 93 12 of of IN cord-301692-zu0ubwfq 93 13 type type NN cord-301692-zu0ubwfq 93 14 I -PRON- PRP cord-301692-zu0ubwfq 93 15 IFNs ifns VBP cord-301692-zu0ubwfq 93 16 and and CC cord-301692-zu0ubwfq 93 17 suggested suggest VBD cord-301692-zu0ubwfq 93 18 that that IN cord-301692-zu0ubwfq 93 19 the the DT cord-301692-zu0ubwfq 93 20 virus virus NN cord-301692-zu0ubwfq 93 21 was be VBD cord-301692-zu0ubwfq 93 22 able able JJ cord-301692-zu0ubwfq 93 23 to to TO cord-301692-zu0ubwfq 93 24 inhibit inhibit VB cord-301692-zu0ubwfq 93 25 IFN IFN NNP cord-301692-zu0ubwfq 93 26 - - : cord-301692-zu0ubwfq 93 27 a a DT cord-301692-zu0ubwfq 93 28 responses response NNS cord-301692-zu0ubwfq 93 29 , , , cord-301692-zu0ubwfq 93 30 since since IN cord-301692-zu0ubwfq 93 31 this this DT cord-301692-zu0ubwfq 93 32 cytokine cytokine NN cord-301692-zu0ubwfq 93 33 could could MD cord-301692-zu0ubwfq 93 34 not not RB cord-301692-zu0ubwfq 93 35 be be VB cord-301692-zu0ubwfq 93 36 detected detect VBN cord-301692-zu0ubwfq 93 37 in in IN cord-301692-zu0ubwfq 93 38 the the DT cord-301692-zu0ubwfq 93 39 lungs lung NNS cord-301692-zu0ubwfq 93 40 of of IN cord-301692-zu0ubwfq 93 41 pigs pig NNS cord-301692-zu0ubwfq 93 42 in in IN cord-301692-zu0ubwfq 93 43 which which WDT cord-301692-zu0ubwfq 93 44 PRRSV PRRSV NNP cord-301692-zu0ubwfq 93 45 was be VBD cord-301692-zu0ubwfq 93 46 actively actively RB cord-301692-zu0ubwfq 93 47 replicating replicate VBG cord-301692-zu0ubwfq 93 48 ( ( -LRB- cord-301692-zu0ubwfq 93 49 Albina Albina NNP cord-301692-zu0ubwfq 93 50 et et FW cord-301692-zu0ubwfq 93 51 al al NNP cord-301692-zu0ubwfq 93 52 . . NNP cord-301692-zu0ubwfq 93 53 , , , cord-301692-zu0ubwfq 93 54 1998 1998 CD cord-301692-zu0ubwfq 93 55 ; ; : cord-301692-zu0ubwfq 93 56 Buddaert Buddaert NNP cord-301692-zu0ubwfq 93 57 et et NNP cord-301692-zu0ubwfq 93 58 al al NNP cord-301692-zu0ubwfq 93 59 . . NNP cord-301692-zu0ubwfq 93 60 , , , cord-301692-zu0ubwfq 93 61 1998 1998 CD cord-301692-zu0ubwfq 93 62 ) ) -RRB- cord-301692-zu0ubwfq 93 63 . . . cord-301692-zu0ubwfq 94 1 IFN IFN NNP cord-301692-zu0ubwfq 94 2 - - : cord-301692-zu0ubwfq 94 3 a a DT cord-301692-zu0ubwfq 94 4 levels level NNS cord-301692-zu0ubwfq 94 5 in in IN cord-301692-zu0ubwfq 94 6 the the DT cord-301692-zu0ubwfq 94 7 lungs lung NNS cord-301692-zu0ubwfq 94 8 of of IN cord-301692-zu0ubwfq 94 9 PRRSV PRRSV NNP cord-301692-zu0ubwfq 94 10 - - HYPH cord-301692-zu0ubwfq 94 11 infected infect VBN cord-301692-zu0ubwfq 94 12 pigs pig NNS cord-301692-zu0ubwfq 94 13 were be VBD cord-301692-zu0ubwfq 94 14 much much RB cord-301692-zu0ubwfq 94 15 lower low JJR cord-301692-zu0ubwfq 94 16 than than IN cord-301692-zu0ubwfq 94 17 in in IN cord-301692-zu0ubwfq 94 18 the the DT cord-301692-zu0ubwfq 94 19 lungs lung NNS cord-301692-zu0ubwfq 94 20 of of IN cord-301692-zu0ubwfq 94 21 pigs pig NNS cord-301692-zu0ubwfq 94 22 infected infect VBN cord-301692-zu0ubwfq 94 23 with with IN cord-301692-zu0ubwfq 94 24 porcine porcine JJ cord-301692-zu0ubwfq 94 25 coronavirus coronavirus NN cord-301692-zu0ubwfq 94 26 or or CC cord-301692-zu0ubwfq 94 27 swine swine NN cord-301692-zu0ubwfq 94 28 influenza influenza NN cord-301692-zu0ubwfq 94 29 virus virus NN cord-301692-zu0ubwfq 94 30 ( ( -LRB- cord-301692-zu0ubwfq 94 31 van van NNP cord-301692-zu0ubwfq 94 32 Reeth Reeth NNP cord-301692-zu0ubwfq 94 33 et et NNP cord-301692-zu0ubwfq 94 34 al al NNP cord-301692-zu0ubwfq 94 35 . . NNP cord-301692-zu0ubwfq 94 36 , , , cord-301692-zu0ubwfq 94 37 1999 1999 CD cord-301692-zu0ubwfq 94 38 ) ) -RRB- cord-301692-zu0ubwfq 94 39 . . . cord-301692-zu0ubwfq 95 1 Frequencies frequency NNS cord-301692-zu0ubwfq 95 2 of of IN cord-301692-zu0ubwfq 95 3 virus virus NN cord-301692-zu0ubwfq 95 4 - - HYPH cord-301692-zu0ubwfq 95 5 specific specific JJ cord-301692-zu0ubwfq 95 6 IFN IFN NNP cord-301692-zu0ubwfq 95 7 - - HYPH cord-301692-zu0ubwfq 95 8 c c NNP cord-301692-zu0ubwfq 95 9 secreting secreting NN cord-301692-zu0ubwfq 95 10 cells cell NNS cord-301692-zu0ubwfq 95 11 were be VBD cord-301692-zu0ubwfq 95 12 correlated correlate VBN cord-301692-zu0ubwfq 95 13 with with IN cord-301692-zu0ubwfq 95 14 the the DT cord-301692-zu0ubwfq 95 15 frequencies frequency NNS cord-301692-zu0ubwfq 95 16 of of IN cord-301692-zu0ubwfq 95 17 IFN IFN NNP cord-301692-zu0ubwfq 95 18 - - : cord-301692-zu0ubwfq 95 19 a a DT cord-301692-zu0ubwfq 95 20 secreting secrete VBG cord-301692-zu0ubwfq 95 21 cells cell NNS cord-301692-zu0ubwfq 95 22 in in IN cord-301692-zu0ubwfq 95 23 pigs pig NNS cord-301692-zu0ubwfq 95 24 infected infect VBN cord-301692-zu0ubwfq 95 25 with with IN cord-301692-zu0ubwfq 95 26 PRRSV PRRSV NNP cord-301692-zu0ubwfq 96 1 ( ( -LRB- cord-301692-zu0ubwfq 96 2 Royaee Royaee NNP cord-301692-zu0ubwfq 96 3 et et NNP cord-301692-zu0ubwfq 96 4 al al NNP cord-301692-zu0ubwfq 96 5 . . NNP cord-301692-zu0ubwfq 96 6 , , , cord-301692-zu0ubwfq 96 7 2004 2004 CD cord-301692-zu0ubwfq 96 8 ) ) -RRB- cord-301692-zu0ubwfq 96 9 . . . cord-301692-zu0ubwfq 97 1 Although although IN cord-301692-zu0ubwfq 97 2 the the DT cord-301692-zu0ubwfq 97 3 exact exact JJ cord-301692-zu0ubwfq 97 4 mechanism mechanism NN cord-301692-zu0ubwfq 97 5 by by IN cord-301692-zu0ubwfq 97 6 which which WDT cord-301692-zu0ubwfq 97 7 PRRSV PRRSV NNP cord-301692-zu0ubwfq 97 8 inhibits inhibit VBZ cord-301692-zu0ubwfq 97 9 IFN IFN NNP cord-301692-zu0ubwfq 97 10 - - HYPH cord-301692-zu0ubwfq 97 11 a a NN cord-301692-zu0ubwfq 97 12 is be VBZ cord-301692-zu0ubwfq 97 13 unknown unknown JJ cord-301692-zu0ubwfq 97 14 , , , cord-301692-zu0ubwfq 97 15 it -PRON- PRP cord-301692-zu0ubwfq 97 16 does do VBZ cord-301692-zu0ubwfq 97 17 not not RB cord-301692-zu0ubwfq 97 18 involve involve VB cord-301692-zu0ubwfq 97 19 inhibition inhibition NN cord-301692-zu0ubwfq 97 20 of of IN cord-301692-zu0ubwfq 97 21 the the DT cord-301692-zu0ubwfq 97 22 nuclear nuclear JJ cord-301692-zu0ubwfq 97 23 factor factor NN cord-301692-zu0ubwfq 97 24 ( ( -LRB- cord-301692-zu0ubwfq 97 25 NF)-j NF)-j NNP cord-301692-zu0ubwfq 97 26 B B NNP cord-301692-zu0ubwfq 97 27 pathway pathway NN cord-301692-zu0ubwfq 97 28 ( ( -LRB- cord-301692-zu0ubwfq 97 29 Lee Lee NNP cord-301692-zu0ubwfq 97 30 and and CC cord-301692-zu0ubwfq 97 31 Kleiboeker Kleiboeker NNP cord-301692-zu0ubwfq 97 32 , , , cord-301692-zu0ubwfq 97 33 2005 2005 CD cord-301692-zu0ubwfq 97 34 ) ) -RRB- cord-301692-zu0ubwfq 97 35 . . . cord-301692-zu0ubwfq 98 1 Different different JJ cord-301692-zu0ubwfq 98 2 PRRSV PRRSV NNP cord-301692-zu0ubwfq 98 3 isolates isolate NNS cord-301692-zu0ubwfq 98 4 and and CC cord-301692-zu0ubwfq 98 5 different different JJ cord-301692-zu0ubwfq 98 6 plaque plaque NN cord-301692-zu0ubwfq 98 7 clones clone NNS cord-301692-zu0ubwfq 98 8 of of IN cord-301692-zu0ubwfq 98 9 the the DT cord-301692-zu0ubwfq 98 10 same same JJ cord-301692-zu0ubwfq 98 11 strain strain NN cord-301692-zu0ubwfq 98 12 have have VBP cord-301692-zu0ubwfq 98 13 different different JJ cord-301692-zu0ubwfq 98 14 abilities ability NNS cord-301692-zu0ubwfq 98 15 to to TO cord-301692-zu0ubwfq 98 16 induce induce VB cord-301692-zu0ubwfq 98 17 or or CC cord-301692-zu0ubwfq 98 18 inhibit inhibit VB cord-301692-zu0ubwfq 98 19 IFN IFN NNP cord-301692-zu0ubwfq 98 20 - - HYPH cord-301692-zu0ubwfq 98 21 a a NNP cord-301692-zu0ubwfq 98 22 ( ( -LRB- cord-301692-zu0ubwfq 98 23 Lee Lee NNP cord-301692-zu0ubwfq 98 24 et et NNP cord-301692-zu0ubwfq 98 25 al al NNP cord-301692-zu0ubwfq 98 26 . . NNP cord-301692-zu0ubwfq 98 27 , , , cord-301692-zu0ubwfq 98 28 2004 2004 CD cord-301692-zu0ubwfq 98 29 ) ) -RRB- cord-301692-zu0ubwfq 98 30 . . . cord-301692-zu0ubwfq 99 1 Preliminary preliminary JJ cord-301692-zu0ubwfq 99 2 results result NNS cord-301692-zu0ubwfq 99 3 indicate indicate VBP cord-301692-zu0ubwfq 99 4 that that IN cord-301692-zu0ubwfq 99 5 different different JJ cord-301692-zu0ubwfq 99 6 European european JJ cord-301692-zu0ubwfq 99 7 PRRSV PRRSV NNP cord-301692-zu0ubwfq 99 8 isolates isolate NNS cord-301692-zu0ubwfq 99 9 have have VBP cord-301692-zu0ubwfq 99 10 different different JJ cord-301692-zu0ubwfq 99 11 abilities ability NNS cord-301692-zu0ubwfq 99 12 to to TO cord-301692-zu0ubwfq 99 13 induce induce VB cord-301692-zu0ubwfq 99 14 not not RB cord-301692-zu0ubwfq 99 15 only only RB cord-301692-zu0ubwfq 99 16 IFN IFN NNP cord-301692-zu0ubwfq 99 17 - - HYPH cord-301692-zu0ubwfq 99 18 a a NN cord-301692-zu0ubwfq 99 19 , , , cord-301692-zu0ubwfq 99 20 but but CC cord-301692-zu0ubwfq 99 21 also also RB cord-301692-zu0ubwfq 100 1 TNF TNF NNP cord-301692-zu0ubwfq 100 2 - - HYPH cord-301692-zu0ubwfq 100 3 a a NNP cord-301692-zu0ubwfq 100 4 , , , cord-301692-zu0ubwfq 100 5 IL-10 IL-10 NNP cord-301692-zu0ubwfq 100 6 and and CC cord-301692-zu0ubwfq 100 7 IL-12 IL-12 NNP cord-301692-zu0ubwfq 100 8 , , , cord-301692-zu0ubwfq 100 9 in in IN cord-301692-zu0ubwfq 100 10 alveolar alveolar JJ cord-301692-zu0ubwfq 100 11 macrophages macrophage NNS cord-301692-zu0ubwfq 100 12 and and CC cord-301692-zu0ubwfq 100 13 dendritic dendritic JJ cord-301692-zu0ubwfq 100 14 cells cell NNS cord-301692-zu0ubwfq 100 15 ( ( -LRB- cord-301692-zu0ubwfq 100 16 unpublished unpublished JJ cord-301692-zu0ubwfq 100 17 observations observation NNS cord-301692-zu0ubwfq 100 18 ) ) -RRB- cord-301692-zu0ubwfq 100 19 . . . cord-301692-zu0ubwfq 101 1 Impairment impairment NN cord-301692-zu0ubwfq 101 2 of of IN cord-301692-zu0ubwfq 101 3 IFN IFN NNP cord-301692-zu0ubwfq 101 4 - - : cord-301692-zu0ubwfq 101 5 a a DT cord-301692-zu0ubwfq 101 6 secretion secretion NN cord-301692-zu0ubwfq 101 7 would would MD cord-301692-zu0ubwfq 101 8 be be VB cord-301692-zu0ubwfq 101 9 expected expect VBN cord-301692-zu0ubwfq 101 10 to to TO cord-301692-zu0ubwfq 101 11 affect affect VB cord-301692-zu0ubwfq 101 12 the the DT cord-301692-zu0ubwfq 101 13 development development NN cord-301692-zu0ubwfq 101 14 of of IN cord-301692-zu0ubwfq 101 15 an an DT cord-301692-zu0ubwfq 101 16 effective effective JJ cord-301692-zu0ubwfq 101 17 T T NNP cord-301692-zu0ubwfq 101 18 helper helper NN cord-301692-zu0ubwfq 101 19 type type NN cord-301692-zu0ubwfq 101 20 1 1 CD cord-301692-zu0ubwfq 101 21 ( ( -LRB- cord-301692-zu0ubwfq 101 22 Th1 th1 CD cord-301692-zu0ubwfq 101 23 ) ) -RRB- cord-301692-zu0ubwfq 101 24 immune immune JJ cord-301692-zu0ubwfq 101 25 response response NN cord-301692-zu0ubwfq 101 26 . . . cord-301692-zu0ubwfq 102 1 Cytokines Cytokines NNP cord-301692-zu0ubwfq 102 2 IL-10 IL-10 NNP cord-301692-zu0ubwfq 102 3 may may MD cord-301692-zu0ubwfq 102 4 have have VB cord-301692-zu0ubwfq 102 5 an an DT cord-301692-zu0ubwfq 102 6 important important JJ cord-301692-zu0ubwfq 102 7 role role NN cord-301692-zu0ubwfq 102 8 in in IN cord-301692-zu0ubwfq 102 9 the the DT cord-301692-zu0ubwfq 102 10 regulation regulation NN cord-301692-zu0ubwfq 102 11 of of IN cord-301692-zu0ubwfq 102 12 the the DT cord-301692-zu0ubwfq 102 13 immune immune JJ cord-301692-zu0ubwfq 102 14 response response NN cord-301692-zu0ubwfq 102 15 to to IN cord-301692-zu0ubwfq 102 16 PRRSV PRRSV NNP cord-301692-zu0ubwfq 102 17 . . . cord-301692-zu0ubwfq 103 1 After after IN cord-301692-zu0ubwfq 103 2 infection infection NN cord-301692-zu0ubwfq 103 3 with with IN cord-301692-zu0ubwfq 103 4 either either CC cord-301692-zu0ubwfq 103 5 European european JJ cord-301692-zu0ubwfq 103 6 or or CC cord-301692-zu0ubwfq 103 7 American american JJ cord-301692-zu0ubwfq 103 8 strains strain NNS cord-301692-zu0ubwfq 103 9 of of IN cord-301692-zu0ubwfq 103 10 PRRSV PRRSV NNP cord-301692-zu0ubwfq 103 11 , , , cord-301692-zu0ubwfq 103 12 levels level NNS cord-301692-zu0ubwfq 103 13 of of IN cord-301692-zu0ubwfq 103 14 IL-10 IL-10 NNP cord-301692-zu0ubwfq 103 15 mRNA mRNA NNP cord-301692-zu0ubwfq 103 16 were be VBD cord-301692-zu0ubwfq 103 17 increased increase VBN cord-301692-zu0ubwfq 103 18 in in IN cord-301692-zu0ubwfq 103 19 porcine porcine JJ cord-301692-zu0ubwfq 103 20 PBMCs pbmc NNS cord-301692-zu0ubwfq 103 21 and and CC cord-301692-zu0ubwfq 103 22 concentrations concentration NNS cord-301692-zu0ubwfq 103 23 of of IN cord-301692-zu0ubwfq 103 24 IL-10 IL-10 NNP cord-301692-zu0ubwfq 103 25 were be VBD cord-301692-zu0ubwfq 103 26 increased increase VBN cord-301692-zu0ubwfq 103 27 in in IN cord-301692-zu0ubwfq 103 28 bronchoalveolar bronchoalveolar NNP cord-301692-zu0ubwfq 103 29 lavage lavage NNP cord-301692-zu0ubwfq 103 30 ( ( -LRB- cord-301692-zu0ubwfq 103 31 BAL BAL NNP cord-301692-zu0ubwfq 103 32 ) ) -RRB- cord-301692-zu0ubwfq 103 33 fluid fluid NN cord-301692-zu0ubwfq 103 34 ( ( -LRB- cord-301692-zu0ubwfq 103 35 Thanawongnuwech Thanawongnuwech NNP cord-301692-zu0ubwfq 103 36 et et NNP cord-301692-zu0ubwfq 103 37 al al NNP cord-301692-zu0ubwfq 103 38 . . NNP cord-301692-zu0ubwfq 103 39 , , , cord-301692-zu0ubwfq 103 40 2004 2004 CD cord-301692-zu0ubwfq 103 41 ) ) -RRB- cord-301692-zu0ubwfq 103 42 . . . cord-301692-zu0ubwfq 104 1 Some some DT cord-301692-zu0ubwfq 104 2 European european JJ cord-301692-zu0ubwfq 104 3 strains strain NNS cord-301692-zu0ubwfq 104 4 of of IN cord-301692-zu0ubwfq 104 5 PRRSV PRRSV NNP cord-301692-zu0ubwfq 104 6 induce induce VBP cord-301692-zu0ubwfq 104 7 strong strong JJ cord-301692-zu0ubwfq 104 8 IL-10 IL-10 NNP cord-301692-zu0ubwfq 104 9 responses response NNS cord-301692-zu0ubwfq 104 10 in in IN cord-301692-zu0ubwfq 104 11 PBMCs pbmc NNS cord-301692-zu0ubwfq 104 12 from from IN cord-301692-zu0ubwfq 104 13 naïve naïve JJ cord-301692-zu0ubwfq 104 14 pigs pig NNS cord-301692-zu0ubwfq 104 15 , , , cord-301692-zu0ubwfq 104 16 suggesting suggest VBG cord-301692-zu0ubwfq 104 17 that that IN cord-301692-zu0ubwfq 104 18 this this DT cord-301692-zu0ubwfq 104 19 is be VBZ cord-301692-zu0ubwfq 104 20 a a DT cord-301692-zu0ubwfq 104 21 not not RB cord-301692-zu0ubwfq 104 22 a a DT cord-301692-zu0ubwfq 104 23 memory memory NN cord-301692-zu0ubwfq 104 24 feature feature NN cord-301692-zu0ubwfq 104 25 ( ( -LRB- cord-301692-zu0ubwfq 104 26 Diaz Diaz NNP cord-301692-zu0ubwfq 104 27 et et NNP cord-301692-zu0ubwfq 104 28 al al NNP cord-301692-zu0ubwfq 104 29 . . NNP cord-301692-zu0ubwfq 104 30 , , , cord-301692-zu0ubwfq 104 31 2006 2006 CD cord-301692-zu0ubwfq 104 32 ) ) -RRB- cord-301692-zu0ubwfq 104 33 . . . cord-301692-zu0ubwfq 105 1 Pigs pig NNS cord-301692-zu0ubwfq 105 2 vaccinated vaccinate VBN cord-301692-zu0ubwfq 105 3 with with IN cord-301692-zu0ubwfq 105 4 IL-10-inducing IL-10-inducing NNP cord-301692-zu0ubwfq 105 5 strains strain NNS cord-301692-zu0ubwfq 105 6 had have VBD cord-301692-zu0ubwfq 105 7 lower low JJR cord-301692-zu0ubwfq 105 8 frequencies frequency NNS cord-301692-zu0ubwfq 105 9 of of IN cord-301692-zu0ubwfq 105 10 PRRSVspecific PRRSVspecific NNP cord-301692-zu0ubwfq 105 11 IFN IFN NNP cord-301692-zu0ubwfq 105 12 - - HYPH cord-301692-zu0ubwfq 105 13 c c NNP cord-301692-zu0ubwfq 105 14 secreting secreting NN cord-301692-zu0ubwfq 105 15 cells cell NNS cord-301692-zu0ubwfq 105 16 than than IN cord-301692-zu0ubwfq 105 17 animals animal NNS cord-301692-zu0ubwfq 105 18 vaccinated vaccinate VBN cord-301692-zu0ubwfq 105 19 with with IN cord-301692-zu0ubwfq 105 20 a a DT cord-301692-zu0ubwfq 105 21 non non JJ cord-301692-zu0ubwfq 105 22 - - JJ cord-301692-zu0ubwfq 105 23 IL-10 il-10 JJ cord-301692-zu0ubwfq 105 24 inducing induce VBG cord-301692-zu0ubwfq 105 25 strain strain NN cord-301692-zu0ubwfq 105 26 ( ( -LRB- cord-301692-zu0ubwfq 105 27 Diaz Diaz NNP cord-301692-zu0ubwfq 105 28 et et NNP cord-301692-zu0ubwfq 105 29 al al NNP cord-301692-zu0ubwfq 105 30 . . NNP cord-301692-zu0ubwfq 105 31 , , , cord-301692-zu0ubwfq 105 32 2006 2006 CD cord-301692-zu0ubwfq 105 33 ) ) -RRB- cord-301692-zu0ubwfq 105 34 . . . cord-301692-zu0ubwfq 106 1 Monocytes monocyte NNS cord-301692-zu0ubwfq 106 2 appear appear VBP cord-301692-zu0ubwfq 106 3 to to TO cord-301692-zu0ubwfq 106 4 be be VB cord-301692-zu0ubwfq 106 5 the the DT cord-301692-zu0ubwfq 106 6 major major JJ cord-301692-zu0ubwfq 106 7 source source NN cord-301692-zu0ubwfq 106 8 of of IN cord-301692-zu0ubwfq 106 9 IL-10 IL-10 NNP cord-301692-zu0ubwfq 106 10 in in IN cord-301692-zu0ubwfq 106 11 PRRSV PRRSV NNP cord-301692-zu0ubwfq 106 12 infection infection NN cord-301692-zu0ubwfq 107 1 ( ( -LRB- cord-301692-zu0ubwfq 107 2 Charerntantanakul Charerntantanakul NNP cord-301692-zu0ubwfq 107 3 et et FW cord-301692-zu0ubwfq 107 4 al al NNP cord-301692-zu0ubwfq 107 5 . . NNP cord-301692-zu0ubwfq 107 6 , , , cord-301692-zu0ubwfq 107 7 2006 2006 CD cord-301692-zu0ubwfq 107 8 ) ) -RRB- cord-301692-zu0ubwfq 107 9 . . . cord-301692-zu0ubwfq 108 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 108 2 also also RB cord-301692-zu0ubwfq 108 3 appears appear VBZ cord-301692-zu0ubwfq 108 4 to to TO cord-301692-zu0ubwfq 108 5 induce induce VB cord-301692-zu0ubwfq 108 6 IL-6 IL-6 NNP cord-301692-zu0ubwfq 108 7 ( ( -LRB- cord-301692-zu0ubwfq 108 8 Asai Asai NNP cord-301692-zu0ubwfq 108 9 et et FW cord-301692-zu0ubwfq 108 10 al al NNP cord-301692-zu0ubwfq 108 11 . . . cord-301692-zu0ubwfq 109 1 , , , cord-301692-zu0ubwfq 109 2 1999 1999 CD cord-301692-zu0ubwfq 109 3 ; ; : cord-301692-zu0ubwfq 109 4 Sipos Sipos NNP cord-301692-zu0ubwfq 109 5 et et NNP cord-301692-zu0ubwfq 109 6 al al NNP cord-301692-zu0ubwfq 109 7 . . NNP cord-301692-zu0ubwfq 109 8 , , , cord-301692-zu0ubwfq 109 9 2003 2003 CD cord-301692-zu0ubwfq 109 10 ) ) -RRB- cord-301692-zu0ubwfq 109 11 , , , cord-301692-zu0ubwfq 109 12 whereas whereas IN cord-301692-zu0ubwfq 109 13 the the DT cord-301692-zu0ubwfq 109 14 role role NN cord-301692-zu0ubwfq 109 15 of of IN cord-301692-zu0ubwfq 109 16 transforming transform VBG cord-301692-zu0ubwfq 109 17 growth growth NN cord-301692-zu0ubwfq 109 18 factor factor NN cord-301692-zu0ubwfq 109 19 - - : cord-301692-zu0ubwfq 109 20 b b NN cord-301692-zu0ubwfq 109 21 in in IN cord-301692-zu0ubwfq 109 22 PRRSV PRRSV NNP cord-301692-zu0ubwfq 109 23 infection infection NN cord-301692-zu0ubwfq 109 24 is be VBZ cord-301692-zu0ubwfq 109 25 unclear unclear JJ cord-301692-zu0ubwfq 109 26 ( ( -LRB- cord-301692-zu0ubwfq 110 1 Royaee Royaee NNP cord-301692-zu0ubwfq 110 2 et et NNP cord-301692-zu0ubwfq 110 3 al al NNP cord-301692-zu0ubwfq 110 4 . . NNP cord-301692-zu0ubwfq 110 5 , , , cord-301692-zu0ubwfq 110 6 2004 2004 CD cord-301692-zu0ubwfq 110 7 ) ) -RRB- cord-301692-zu0ubwfq 110 8 . . . cord-301692-zu0ubwfq 111 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 111 2 may may MD cord-301692-zu0ubwfq 111 3 interfere interfere VB cord-301692-zu0ubwfq 111 4 with with IN cord-301692-zu0ubwfq 111 5 correct correct JJ cord-301692-zu0ubwfq 111 6 antigen antigen NN cord-301692-zu0ubwfq 111 7 presentation presentation NN cord-301692-zu0ubwfq 111 8 and and CC cord-301692-zu0ubwfq 111 9 activation activation NN cord-301692-zu0ubwfq 111 10 of of IN cord-301692-zu0ubwfq 111 11 T t NN cord-301692-zu0ubwfq 111 12 lymphocytes lymphocyte NNS cord-301692-zu0ubwfq 111 13 . . . cord-301692-zu0ubwfq 112 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 112 2 down down RB cord-301692-zu0ubwfq 112 3 - - HYPH cord-301692-zu0ubwfq 112 4 regulated regulate VBN cord-301692-zu0ubwfq 112 5 expression expression NN cord-301692-zu0ubwfq 112 6 of of IN cord-301692-zu0ubwfq 112 7 major major JJ cord-301692-zu0ubwfq 112 8 histocompatibility histocompatibility NN cord-301692-zu0ubwfq 112 9 complex complex NN cord-301692-zu0ubwfq 112 10 ( ( -LRB- cord-301692-zu0ubwfq 112 11 MHC)-I mhc)-i NN cord-301692-zu0ubwfq 112 12 in in IN cord-301692-zu0ubwfq 112 13 dendritic dendritic JJ cord-301692-zu0ubwfq 112 14 cells cell NNS cord-301692-zu0ubwfq 112 15 ( ( -LRB- cord-301692-zu0ubwfq 112 16 DCs DCs NNP cord-301692-zu0ubwfq 112 17 ) ) -RRB- cord-301692-zu0ubwfq 112 18 , , , cord-301692-zu0ubwfq 112 19 although although IN cord-301692-zu0ubwfq 112 20 this this DT cord-301692-zu0ubwfq 112 21 was be VBD cord-301692-zu0ubwfq 112 22 not not RB cord-301692-zu0ubwfq 112 23 correlated correlate VBN cord-301692-zu0ubwfq 112 24 with with IN cord-301692-zu0ubwfq 112 25 impaired impaired JJ cord-301692-zu0ubwfq 112 26 proliferative proliferative JJ cord-301692-zu0ubwfq 112 27 responses response NNS cord-301692-zu0ubwfq 112 28 in in IN cord-301692-zu0ubwfq 112 29 the the DT cord-301692-zu0ubwfq 112 30 mixed mixed JJ cord-301692-zu0ubwfq 112 31 leucocyte leucocyte NN cord-301692-zu0ubwfq 112 32 reaction reaction NN cord-301692-zu0ubwfq 112 33 ( ( -LRB- cord-301692-zu0ubwfq 112 34 Loving love VBG cord-301692-zu0ubwfq 112 35 et et FW cord-301692-zu0ubwfq 112 36 al al NNP cord-301692-zu0ubwfq 112 37 . . NNP cord-301692-zu0ubwfq 112 38 , , , cord-301692-zu0ubwfq 112 39 2007 2007 CD cord-301692-zu0ubwfq 112 40 ) ) -RRB- cord-301692-zu0ubwfq 112 41 . . . cord-301692-zu0ubwfq 113 1 Expression expression NN cord-301692-zu0ubwfq 113 2 of of IN cord-301692-zu0ubwfq 113 3 MHC MHC NNP cord-301692-zu0ubwfq 113 4 - - : cord-301692-zu0ubwfq 113 5 I I NNP cord-301692-zu0ubwfq 113 6 and and CC cord-301692-zu0ubwfq 113 7 MHC MHC NNP cord-301692-zu0ubwfq 113 8 - - HYPH cord-301692-zu0ubwfq 113 9 II II NNP cord-301692-zu0ubwfq 113 10 , , , cord-301692-zu0ubwfq 113 11 as as RB cord-301692-zu0ubwfq 113 12 well well RB cord-301692-zu0ubwfq 113 13 as as IN cord-301692-zu0ubwfq 113 14 CD14 CD14 NNP cord-301692-zu0ubwfq 113 15 , , , cord-301692-zu0ubwfq 113 16 was be VBD cord-301692-zu0ubwfq 113 17 down down RB cord-301692-zu0ubwfq 113 18 - - HYPH cord-301692-zu0ubwfq 113 19 regulated regulate VBN cord-301692-zu0ubwfq 113 20 in in IN cord-301692-zu0ubwfq 113 21 monocyte monocyte NNP cord-301692-zu0ubwfq 113 22 - - HYPH cord-301692-zu0ubwfq 113 23 derived derive VBN cord-301692-zu0ubwfq 113 24 DCs dc NNS cord-301692-zu0ubwfq 113 25 stimulated stimulate VBN cord-301692-zu0ubwfq 113 26 by by IN cord-301692-zu0ubwfq 113 27 infectious infectious JJ cord-301692-zu0ubwfq 113 28 but but CC cord-301692-zu0ubwfq 113 29 not not RB cord-301692-zu0ubwfq 113 30 inactivated inactivate VBN cord-301692-zu0ubwfq 113 31 PRRSV PRRSV NNP cord-301692-zu0ubwfq 113 32 ( ( -LRB- cord-301692-zu0ubwfq 113 33 Wang Wang NNP cord-301692-zu0ubwfq 113 34 et et NNP cord-301692-zu0ubwfq 113 35 al al NNP cord-301692-zu0ubwfq 113 36 . . NNP cord-301692-zu0ubwfq 113 37 , , , cord-301692-zu0ubwfq 113 38 2007 2007 CD cord-301692-zu0ubwfq 113 39 ) ) -RRB- cord-301692-zu0ubwfq 113 40 . . . cord-301692-zu0ubwfq 114 1 In in IN cord-301692-zu0ubwfq 114 2 this this DT cord-301692-zu0ubwfq 114 3 study study NN cord-301692-zu0ubwfq 114 4 , , , cord-301692-zu0ubwfq 114 5 proliferative proliferative JJ cord-301692-zu0ubwfq 114 6 responses response NNS cord-301692-zu0ubwfq 114 7 were be VBD cord-301692-zu0ubwfq 114 8 decreased decrease VBN cord-301692-zu0ubwfq 114 9 when when WRB cord-301692-zu0ubwfq 114 10 infected infected JJ cord-301692-zu0ubwfq 114 11 DCs dc NNS cord-301692-zu0ubwfq 114 12 were be VBD cord-301692-zu0ubwfq 114 13 used use VBN cord-301692-zu0ubwfq 114 14 with with IN cord-301692-zu0ubwfq 114 15 syngeneic syngeneic NNS cord-301692-zu0ubwfq 114 16 or or CC cord-301692-zu0ubwfq 114 17 allogeneic allogeneic NN cord-301692-zu0ubwfq 114 18 lymphocytes lymphocyte NNS cord-301692-zu0ubwfq 114 19 , , , cord-301692-zu0ubwfq 114 20 suggesting suggest VBG cord-301692-zu0ubwfq 114 21 that that IN cord-301692-zu0ubwfq 114 22 infected infected JJ cord-301692-zu0ubwfq 114 23 DCs DCs NNP cord-301692-zu0ubwfq 114 24 present present JJ cord-301692-zu0ubwfq 114 25 antigens antigen NNS cord-301692-zu0ubwfq 114 26 less less RBR cord-301692-zu0ubwfq 114 27 efficiently efficiently RB cord-301692-zu0ubwfq 114 28 ( ( -LRB- cord-301692-zu0ubwfq 114 29 Wang Wang NNP cord-301692-zu0ubwfq 114 30 et et NNP cord-301692-zu0ubwfq 114 31 al al NNP cord-301692-zu0ubwfq 114 32 . . NNP cord-301692-zu0ubwfq 114 33 , , , cord-301692-zu0ubwfq 114 34 2007 2007 CD cord-301692-zu0ubwfq 114 35 ) ) -RRB- cord-301692-zu0ubwfq 114 36 . . . cord-301692-zu0ubwfq 115 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 115 2 may may MD cord-301692-zu0ubwfq 115 3 down down RB cord-301692-zu0ubwfq 115 4 - - HYPH cord-301692-zu0ubwfq 115 5 regulate regulate VB cord-301692-zu0ubwfq 115 6 the the DT cord-301692-zu0ubwfq 115 7 innate innate JJ cord-301692-zu0ubwfq 115 8 immune immune JJ cord-301692-zu0ubwfq 115 9 response response NN cord-301692-zu0ubwfq 115 10 by by IN cord-301692-zu0ubwfq 115 11 altering alter VBG cord-301692-zu0ubwfq 115 12 the the DT cord-301692-zu0ubwfq 115 13 cytokine cytokine NN cord-301692-zu0ubwfq 115 14 patterns pattern NNS cord-301692-zu0ubwfq 115 15 of of IN cord-301692-zu0ubwfq 115 16 macrophages macrophage NNS cord-301692-zu0ubwfq 115 17 and and CC cord-301692-zu0ubwfq 115 18 dendritic dendritic JJ cord-301692-zu0ubwfq 115 19 cells cell NNS cord-301692-zu0ubwfq 115 20 , , , cord-301692-zu0ubwfq 115 21 as as RB cord-301692-zu0ubwfq 115 22 well well RB cord-301692-zu0ubwfq 115 23 as as IN cord-301692-zu0ubwfq 115 24 by by IN cord-301692-zu0ubwfq 115 25 modifying modify VBG cord-301692-zu0ubwfq 115 26 the the DT cord-301692-zu0ubwfq 115 27 expression expression NN cord-301692-zu0ubwfq 115 28 of of IN cord-301692-zu0ubwfq 115 29 molecules molecule NNS cord-301692-zu0ubwfq 115 30 involved involve VBN cord-301692-zu0ubwfq 115 31 in in IN cord-301692-zu0ubwfq 115 32 antigen antigen NN cord-301692-zu0ubwfq 115 33 presentation presentation NN cord-301692-zu0ubwfq 115 34 . . . cord-301692-zu0ubwfq 116 1 As as IN cord-301692-zu0ubwfq 116 2 discussed discuss VBN cord-301692-zu0ubwfq 116 3 previously previously RB cord-301692-zu0ubwfq 116 4 , , , cord-301692-zu0ubwfq 116 5 one one CD cord-301692-zu0ubwfq 116 6 of of IN cord-301692-zu0ubwfq 116 7 the the DT cord-301692-zu0ubwfq 116 8 intriguing intriguing JJ cord-301692-zu0ubwfq 116 9 features feature NNS cord-301692-zu0ubwfq 116 10 of of IN cord-301692-zu0ubwfq 116 11 PRRSV PRRSV NNP cord-301692-zu0ubwfq 116 12 infection infection NN cord-301692-zu0ubwfq 116 13 is be VBZ cord-301692-zu0ubwfq 116 14 the the DT cord-301692-zu0ubwfq 116 15 delayed delay VBN cord-301692-zu0ubwfq 116 16 development development NN cord-301692-zu0ubwfq 116 17 of of IN cord-301692-zu0ubwfq 116 18 NAs NAs NNP cord-301692-zu0ubwfq 116 19 . . . cord-301692-zu0ubwfq 117 1 The the DT cord-301692-zu0ubwfq 117 2 main main JJ cord-301692-zu0ubwfq 117 3 neutralisation neutralisation NN cord-301692-zu0ubwfq 117 4 epitope epitope NN cord-301692-zu0ubwfq 117 5 of of IN cord-301692-zu0ubwfq 117 6 PRRSV PRRSV NNP cord-301692-zu0ubwfq 117 7 , , , cord-301692-zu0ubwfq 117 8 designated designate VBN cord-301692-zu0ubwfq 117 9 epitope epitope NN cord-301692-zu0ubwfq 117 10 B b NN cord-301692-zu0ubwfq 117 11 , , , cord-301692-zu0ubwfq 117 12 is be VBZ cord-301692-zu0ubwfq 117 13 located locate VBN cord-301692-zu0ubwfq 117 14 in in IN cord-301692-zu0ubwfq 117 15 the the DT cord-301692-zu0ubwfq 117 16 N n CD cord-301692-zu0ubwfq 117 17 - - HYPH cord-301692-zu0ubwfq 117 18 terminal terminal NN cord-301692-zu0ubwfq 117 19 ectodomain ectodomain NN cord-301692-zu0ubwfq 117 20 of of IN cord-301692-zu0ubwfq 117 21 GP5 GP5 NNP cord-301692-zu0ubwfq 117 22 ( ( -LRB- cord-301692-zu0ubwfq 117 23 amino amino JJ cord-301692-zu0ubwfq 117 24 acids acid NNS cord-301692-zu0ubwfq 117 25 37 37 CD cord-301692-zu0ubwfq 117 26 - - SYM cord-301692-zu0ubwfq 117 27 44 44 CD cord-301692-zu0ubwfq 117 28 ) ) -RRB- cord-301692-zu0ubwfq 117 29 in in IN cord-301692-zu0ubwfq 117 30 both both CC cord-301692-zu0ubwfq 117 31 American american JJ cord-301692-zu0ubwfq 117 32 and and CC cord-301692-zu0ubwfq 117 33 European european JJ cord-301692-zu0ubwfq 117 34 strains strain NNS cord-301692-zu0ubwfq 117 35 ( ( -LRB- cord-301692-zu0ubwfq 118 1 Ostrowski Ostrowski NNP cord-301692-zu0ubwfq 118 2 et et NNP cord-301692-zu0ubwfq 118 3 al al NNP cord-301692-zu0ubwfq 118 4 . . . cord-301692-zu0ubwfq 119 1 , , , cord-301692-zu0ubwfq 119 2 2002 2002 CD cord-301692-zu0ubwfq 119 3 ; ; : cord-301692-zu0ubwfq 119 4 Plagemann Plagemann NNP cord-301692-zu0ubwfq 119 5 et et NNP cord-301692-zu0ubwfq 119 6 al al NNP cord-301692-zu0ubwfq 119 7 . . . cord-301692-zu0ubwfq 120 1 , , , cord-301692-zu0ubwfq 120 2 2002 2002 CD cord-301692-zu0ubwfq 120 3 ; ; : cord-301692-zu0ubwfq 120 4 Wissink Wissink NNP cord-301692-zu0ubwfq 120 5 et et NNP cord-301692-zu0ubwfq 120 6 al al NNP cord-301692-zu0ubwfq 120 7 . . NNP cord-301692-zu0ubwfq 120 8 , , , cord-301692-zu0ubwfq 120 9 2003 2003 CD cord-301692-zu0ubwfq 121 1 ; ; : cord-301692-zu0ubwfq 121 2 Plagemann Plagemann NNP cord-301692-zu0ubwfq 121 3 , , , cord-301692-zu0ubwfq 121 4 2004 2004 CD cord-301692-zu0ubwfq 121 5 ) ) -RRB- cord-301692-zu0ubwfq 121 6 . . . cord-301692-zu0ubwfq 122 1 This this DT cord-301692-zu0ubwfq 122 2 neutralisation neutralisation NN cord-301692-zu0ubwfq 122 3 epitope epitope NN cord-301692-zu0ubwfq 122 4 is be VBZ cord-301692-zu0ubwfq 122 5 flanked flank VBN cord-301692-zu0ubwfq 122 6 by by IN cord-301692-zu0ubwfq 122 7 glycosylation glycosylation NN cord-301692-zu0ubwfq 122 8 sites site NNS cord-301692-zu0ubwfq 122 9 . . . cord-301692-zu0ubwfq 123 1 An an DT cord-301692-zu0ubwfq 123 2 additional additional JJ cord-301692-zu0ubwfq 123 3 immunodominant immunodominant NN cord-301692-zu0ubwfq 123 4 epitope epitope NN cord-301692-zu0ubwfq 123 5 , , , cord-301692-zu0ubwfq 123 6 designated designate VBN cord-301692-zu0ubwfq 123 7 epitope epitope NN cord-301692-zu0ubwfq 123 8 A A NNP cord-301692-zu0ubwfq 123 9 , , , cord-301692-zu0ubwfq 123 10 is be VBZ cord-301692-zu0ubwfq 123 11 located locate VBN cord-301692-zu0ubwfq 123 12 in in IN cord-301692-zu0ubwfq 123 13 the the DT cord-301692-zu0ubwfq 123 14 N n CD cord-301692-zu0ubwfq 123 15 - - HYPH cord-301692-zu0ubwfq 123 16 terminal terminal NN cord-301692-zu0ubwfq 123 17 ectodomain ectodomain NN cord-301692-zu0ubwfq 123 18 of of IN cord-301692-zu0ubwfq 123 19 GP5 GP5 NNP cord-301692-zu0ubwfq 123 20 ( ( -LRB- cord-301692-zu0ubwfq 123 21 amino amino JJ cord-301692-zu0ubwfq 123 22 acids acid NNS cord-301692-zu0ubwfq 123 23 27 27 CD cord-301692-zu0ubwfq 123 24 and and CC cord-301692-zu0ubwfq 123 25 31 31 CD cord-301692-zu0ubwfq 123 26 ) ) -RRB- cord-301692-zu0ubwfq 123 27 and and CC cord-301692-zu0ubwfq 123 28 has have VBZ cord-301692-zu0ubwfq 123 29 the the DT cord-301692-zu0ubwfq 123 30 characteristics characteristic NNS cord-301692-zu0ubwfq 123 31 of of IN cord-301692-zu0ubwfq 123 32 a a DT cord-301692-zu0ubwfq 123 33 decoy decoy NN cord-301692-zu0ubwfq 123 34 epitope epitope NN cord-301692-zu0ubwfq 123 35 , , , cord-301692-zu0ubwfq 123 36 similar similar JJ cord-301692-zu0ubwfq 123 37 to to IN cord-301692-zu0ubwfq 123 38 that that DT cord-301692-zu0ubwfq 123 39 in in IN cord-301692-zu0ubwfq 123 40 human human JJ cord-301692-zu0ubwfq 123 41 immunodeficiency immunodeficiency NN cord-301692-zu0ubwfq 123 42 virus virus NN cord-301692-zu0ubwfq 123 43 type type NN cord-301692-zu0ubwfq 123 44 1 1 CD cord-301692-zu0ubwfq 124 1 ( ( -LRB- cord-301692-zu0ubwfq 124 2 Ostrowski Ostrowski NNP cord-301692-zu0ubwfq 124 3 et et NNP cord-301692-zu0ubwfq 124 4 al al NNP cord-301692-zu0ubwfq 124 5 . . NNP cord-301692-zu0ubwfq 124 6 , , , cord-301692-zu0ubwfq 124 7 2002 2002 CD cord-301692-zu0ubwfq 124 8 ) ) -RRB- cord-301692-zu0ubwfq 124 9 . . . cord-301692-zu0ubwfq 125 1 The the DT cord-301692-zu0ubwfq 125 2 decoy decoy NN cord-301692-zu0ubwfq 125 3 epitope epitope NN cord-301692-zu0ubwfq 125 4 may may MD cord-301692-zu0ubwfq 125 5 interfere interfere VB cord-301692-zu0ubwfq 125 6 with with IN cord-301692-zu0ubwfq 125 7 the the DT cord-301692-zu0ubwfq 125 8 immune immune JJ cord-301692-zu0ubwfq 125 9 response response NN cord-301692-zu0ubwfq 125 10 to to IN cord-301692-zu0ubwfq 125 11 the the DT cord-301692-zu0ubwfq 125 12 main main JJ cord-301692-zu0ubwfq 125 13 neutralisation neutralisation NN cord-301692-zu0ubwfq 125 14 epitope epitope NN cord-301692-zu0ubwfq 125 15 B b NN cord-301692-zu0ubwfq 125 16 , , , cord-301692-zu0ubwfq 125 17 resulting result VBG cord-301692-zu0ubwfq 125 18 in in IN cord-301692-zu0ubwfq 125 19 a a DT cord-301692-zu0ubwfq 125 20 delay delay NN cord-301692-zu0ubwfq 125 21 in in IN cord-301692-zu0ubwfq 125 22 the the DT cord-301692-zu0ubwfq 125 23 NA NA NNP cord-301692-zu0ubwfq 125 24 response response NN cord-301692-zu0ubwfq 125 25 . . . cord-301692-zu0ubwfq 126 1 Insertion insertion NN cord-301692-zu0ubwfq 126 2 of of IN cord-301692-zu0ubwfq 126 3 a a DT cord-301692-zu0ubwfq 126 4 pan pan JJ cord-301692-zu0ubwfq 126 5 - - JJ cord-301692-zu0ubwfq 126 6 DR DR NNP cord-301692-zu0ubwfq 126 7 helper helper NN cord-301692-zu0ubwfq 126 8 T t NN cord-301692-zu0ubwfq 126 9 cell cell NN cord-301692-zu0ubwfq 126 10 epitope epitope NN cord-301692-zu0ubwfq 126 11 between between IN cord-301692-zu0ubwfq 126 12 the the DT cord-301692-zu0ubwfq 126 13 epitope epitope NN cord-301692-zu0ubwfq 126 14 B b NN cord-301692-zu0ubwfq 126 15 and and CC cord-301692-zu0ubwfq 126 16 the the DT cord-301692-zu0ubwfq 126 17 decoy decoy NN cord-301692-zu0ubwfq 126 18 epitope epitope NN cord-301692-zu0ubwfq 126 19 increased increase VBD cord-301692-zu0ubwfq 126 20 the the DT cord-301692-zu0ubwfq 126 21 immunogenicity immunogenicity NN cord-301692-zu0ubwfq 126 22 of of IN cord-301692-zu0ubwfq 126 23 epitope epitope NN cord-301692-zu0ubwfq 126 24 B b NN cord-301692-zu0ubwfq 126 25 in in IN cord-301692-zu0ubwfq 126 26 mice mouse NNS cord-301692-zu0ubwfq 126 27 ( ( -LRB- cord-301692-zu0ubwfq 126 28 Fang Fang NNP cord-301692-zu0ubwfq 126 29 et et FW cord-301692-zu0ubwfq 126 30 al al NNP cord-301692-zu0ubwfq 126 31 . . NNP cord-301692-zu0ubwfq 126 32 , , , cord-301692-zu0ubwfq 126 33 2006 2006 CD cord-301692-zu0ubwfq 126 34 ) ) -RRB- cord-301692-zu0ubwfq 126 35 , , , cord-301692-zu0ubwfq 126 36 suggesting suggest VBG cord-301692-zu0ubwfq 126 37 that that IN cord-301692-zu0ubwfq 126 38 the the DT cord-301692-zu0ubwfq 126 39 proximity proximity NN cord-301692-zu0ubwfq 126 40 of of IN cord-301692-zu0ubwfq 126 41 epitopes epitope NNS cord-301692-zu0ubwfq 127 1 A a NN cord-301692-zu0ubwfq 127 2 and and CC cord-301692-zu0ubwfq 127 3 B b NN cord-301692-zu0ubwfq 127 4 is be VBZ cord-301692-zu0ubwfq 127 5 important important JJ cord-301692-zu0ubwfq 127 6 in in IN cord-301692-zu0ubwfq 127 7 delaying delay VBG cord-301692-zu0ubwfq 127 8 the the DT cord-301692-zu0ubwfq 127 9 NA NA NNP cord-301692-zu0ubwfq 127 10 response response NN cord-301692-zu0ubwfq 127 11 . . . cord-301692-zu0ubwfq 128 1 The the DT cord-301692-zu0ubwfq 128 2 decoy decoy NN cord-301692-zu0ubwfq 128 3 epitope epitope NN cord-301692-zu0ubwfq 128 4 is be VBZ cord-301692-zu0ubwfq 128 5 not not RB cord-301692-zu0ubwfq 128 6 the the DT cord-301692-zu0ubwfq 128 7 only only JJ cord-301692-zu0ubwfq 128 8 way way NN cord-301692-zu0ubwfq 128 9 by by IN cord-301692-zu0ubwfq 128 10 which which WDT cord-301692-zu0ubwfq 128 11 PRRSV PRRSV NNP cord-301692-zu0ubwfq 128 12 can can MD cord-301692-zu0ubwfq 128 13 evade evade VB cord-301692-zu0ubwfq 128 14 the the DT cord-301692-zu0ubwfq 128 15 humoral humoral JJ cord-301692-zu0ubwfq 128 16 immune immune JJ cord-301692-zu0ubwfq 128 17 response response NN cord-301692-zu0ubwfq 128 18 . . . cord-301692-zu0ubwfq 129 1 GP5 GP5 NNP cord-301692-zu0ubwfq 129 2 , , , cord-301692-zu0ubwfq 129 3 the the DT cord-301692-zu0ubwfq 129 4 main main JJ cord-301692-zu0ubwfq 129 5 target target NN cord-301692-zu0ubwfq 129 6 for for IN cord-301692-zu0ubwfq 129 7 NAs NAs NNP cord-301692-zu0ubwfq 129 8 , , , cord-301692-zu0ubwfq 129 9 contains contain VBZ cord-301692-zu0ubwfq 129 10 up up IN cord-301692-zu0ubwfq 129 11 to to TO cord-301692-zu0ubwfq 129 12 four four CD cord-301692-zu0ubwfq 129 13 glycosylation glycosylation NN cord-301692-zu0ubwfq 129 14 sites site NNS cord-301692-zu0ubwfq 129 15 , , , cord-301692-zu0ubwfq 129 16 located locate VBN cord-301692-zu0ubwfq 129 17 in in IN cord-301692-zu0ubwfq 129 18 or or CC cord-301692-zu0ubwfq 129 19 close close RB cord-301692-zu0ubwfq 129 20 to to IN cord-301692-zu0ubwfq 129 21 the the DT cord-301692-zu0ubwfq 129 22 neutralising neutralise VBG cord-301692-zu0ubwfq 129 23 epitope epitope NN cord-301692-zu0ubwfq 129 24 . . . cord-301692-zu0ubwfq 130 1 American american JJ cord-301692-zu0ubwfq 130 2 field field NN cord-301692-zu0ubwfq 130 3 strains strain NNS cord-301692-zu0ubwfq 130 4 of of IN cord-301692-zu0ubwfq 130 5 PRRSV PRRSV NNP cord-301692-zu0ubwfq 130 6 lacking lack VBG cord-301692-zu0ubwfq 130 7 glycosylation glycosylation NN cord-301692-zu0ubwfq 130 8 sites site NNS cord-301692-zu0ubwfq 130 9 in in IN cord-301692-zu0ubwfq 130 10 the the DT cord-301692-zu0ubwfq 130 11 upstream upstream JJ cord-301692-zu0ubwfq 130 12 hypervariable hypervariable JJ cord-301692-zu0ubwfq 130 13 region region NN cord-301692-zu0ubwfq 130 14 induced induce VBD cord-301692-zu0ubwfq 130 15 NAs NAs NNP cord-301692-zu0ubwfq 130 16 more more RBR cord-301692-zu0ubwfq 130 17 rapidly rapidly RB cord-301692-zu0ubwfq 130 18 and and CC cord-301692-zu0ubwfq 130 19 more more RBR cord-301692-zu0ubwfq 130 20 strongly strongly RB cord-301692-zu0ubwfq 130 21 in in IN cord-301692-zu0ubwfq 130 22 infected infected JJ cord-301692-zu0ubwfq 130 23 pigs pig NNS cord-301692-zu0ubwfq 130 24 than than IN cord-301692-zu0ubwfq 130 25 strains strain NNS cord-301692-zu0ubwfq 130 26 lacking lack VBG cord-301692-zu0ubwfq 130 27 the the DT cord-301692-zu0ubwfq 130 28 downstream downstream JJ cord-301692-zu0ubwfq 130 29 glycosylation glycosylation NN cord-301692-zu0ubwfq 130 30 site site NN cord-301692-zu0ubwfq 130 31 at at IN cord-301692-zu0ubwfq 130 32 position position NN cord-301692-zu0ubwfq 130 33 44 44 CD cord-301692-zu0ubwfq 130 34 ( ( -LRB- cord-301692-zu0ubwfq 130 35 N-44 N-44 NNP cord-301692-zu0ubwfq 130 36 ) ) -RRB- cord-301692-zu0ubwfq 130 37 , , , cord-301692-zu0ubwfq 130 38 even even RB cord-301692-zu0ubwfq 130 39 though though IN cord-301692-zu0ubwfq 130 40 all all DT cord-301692-zu0ubwfq 130 41 strains strain NNS cord-301692-zu0ubwfq 130 42 were be VBD cord-301692-zu0ubwfq 130 43 equally equally RB cord-301692-zu0ubwfq 130 44 susceptible susceptible JJ cord-301692-zu0ubwfq 130 45 to to IN cord-301692-zu0ubwfq 130 46 NAs na NNS cord-301692-zu0ubwfq 130 47 ( ( -LRB- cord-301692-zu0ubwfq 130 48 Faaberg Faaberg NNP cord-301692-zu0ubwfq 130 49 et et FW cord-301692-zu0ubwfq 130 50 al al NNP cord-301692-zu0ubwfq 130 51 . . NNP cord-301692-zu0ubwfq 130 52 , , , cord-301692-zu0ubwfq 130 53 2006 2006 CD cord-301692-zu0ubwfq 130 54 ) ) -RRB- cord-301692-zu0ubwfq 130 55 . . . cord-301692-zu0ubwfq 131 1 As as IN cord-301692-zu0ubwfq 131 2 Spanish spanish JJ cord-301692-zu0ubwfq 131 3 PRRSV PRRSV NNP cord-301692-zu0ubwfq 131 4 strains strain NNS cord-301692-zu0ubwfq 131 5 have have VBP cord-301692-zu0ubwfq 131 6 evolved evolve VBN cord-301692-zu0ubwfq 131 7 from from IN cord-301692-zu0ubwfq 131 8 1991 1991 CD cord-301692-zu0ubwfq 131 9 - - SYM cord-301692-zu0ubwfq 131 10 2005 2005 CD cord-301692-zu0ubwfq 131 11 , , , cord-301692-zu0ubwfq 131 12 there there EX cord-301692-zu0ubwfq 131 13 has have VBZ cord-301692-zu0ubwfq 131 14 been be VBN cord-301692-zu0ubwfq 131 15 a a DT cord-301692-zu0ubwfq 131 16 trend trend NN cord-301692-zu0ubwfq 131 17 to to TO cord-301692-zu0ubwfq 131 18 lose lose VB cord-301692-zu0ubwfq 131 19 the the DT cord-301692-zu0ubwfq 131 20 glycosylation glycosylation NN cord-301692-zu0ubwfq 131 21 site site NN cord-301692-zu0ubwfq 131 22 at at IN cord-301692-zu0ubwfq 131 23 N-46 N-46 NNP cord-301692-zu0ubwfq 131 24 ( ( -LRB- cord-301692-zu0ubwfq 131 25 equivalent equivalent JJ cord-301692-zu0ubwfq 131 26 to to IN cord-301692-zu0ubwfq 131 27 N-44 N-44 NNP cord-301692-zu0ubwfq 131 28 of of IN cord-301692-zu0ubwfq 131 29 American american JJ cord-301692-zu0ubwfq 131 30 strains strain NNS cord-301692-zu0ubwfq 131 31 ) ) -RRB- cord-301692-zu0ubwfq 131 32 and and CC cord-301692-zu0ubwfq 131 33 to to TO cord-301692-zu0ubwfq 131 34 maintain maintain VB cord-301692-zu0ubwfq 131 35 or or CC cord-301692-zu0ubwfq 131 36 gain gain VB cord-301692-zu0ubwfq 131 37 glycosylations glycosylation NNS cord-301692-zu0ubwfq 131 38 in in IN cord-301692-zu0ubwfq 131 39 the the DT cord-301692-zu0ubwfq 131 40 flanking flank VBG cord-301692-zu0ubwfq 131 41 regions region NNS cord-301692-zu0ubwfq 131 42 ( ( -LRB- cord-301692-zu0ubwfq 131 43 N-37 N-37 NNP cord-301692-zu0ubwfq 131 44 and and CC cord-301692-zu0ubwfq 131 45 N-53 N-53 NNP cord-301692-zu0ubwfq 131 46 ) ) -RRB- cord-301692-zu0ubwfq 131 47 , , , cord-301692-zu0ubwfq 131 48 consistent consistent JJ cord-301692-zu0ubwfq 131 49 with with IN cord-301692-zu0ubwfq 131 50 selection selection NN cord-301692-zu0ubwfq 131 51 of of IN cord-301692-zu0ubwfq 131 52 strains strain NNS cord-301692-zu0ubwfq 131 53 inducing induce VBG cord-301692-zu0ubwfq 131 54 weaker weak JJR cord-301692-zu0ubwfq 131 55 NA NA NNP cord-301692-zu0ubwfq 131 56 responses response NNS cord-301692-zu0ubwfq 131 57 ( ( -LRB- cord-301692-zu0ubwfq 131 58 Mateu Mateu NNP cord-301692-zu0ubwfq 131 59 et et NNP cord-301692-zu0ubwfq 131 60 al al NNP cord-301692-zu0ubwfq 131 61 . . NNP cord-301692-zu0ubwfq 131 62 , , , cord-301692-zu0ubwfq 131 63 2006 2006 CD cord-301692-zu0ubwfq 131 64 ) ) -RRB- cord-301692-zu0ubwfq 131 65 . . . cord-301692-zu0ubwfq 132 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 132 2 is be VBZ cord-301692-zu0ubwfq 132 3 divided divide VBN cord-301692-zu0ubwfq 132 4 into into IN cord-301692-zu0ubwfq 132 5 European european JJ cord-301692-zu0ubwfq 132 6 ( ( -LRB- cord-301692-zu0ubwfq 132 7 type type NN cord-301692-zu0ubwfq 132 8 I I NNP cord-301692-zu0ubwfq 132 9 ) ) -RRB- cord-301692-zu0ubwfq 132 10 and and CC cord-301692-zu0ubwfq 132 11 American american JJ cord-301692-zu0ubwfq 132 12 ( ( -LRB- cord-301692-zu0ubwfq 132 13 type type NN cord-301692-zu0ubwfq 132 14 II II NNP cord-301692-zu0ubwfq 132 15 ) ) -RRB- cord-301692-zu0ubwfq 132 16 genotypes genotype NNS cord-301692-zu0ubwfq 132 17 ; ; : cord-301692-zu0ubwfq 132 18 four four CD cord-301692-zu0ubwfq 132 19 subtypes subtype NNS cord-301692-zu0ubwfq 132 20 have have VBP cord-301692-zu0ubwfq 132 21 been be VBN cord-301692-zu0ubwfq 132 22 identified identify VBN cord-301692-zu0ubwfq 132 23 within within IN cord-301692-zu0ubwfq 132 24 the the DT cord-301692-zu0ubwfq 132 25 European european JJ cord-301692-zu0ubwfq 132 26 genotype genotype NN cord-301692-zu0ubwfq 132 27 ( ( -LRB- cord-301692-zu0ubwfq 132 28 Stadejek Stadejek NNP cord-301692-zu0ubwfq 132 29 et et NNP cord-301692-zu0ubwfq 132 30 al al NNP cord-301692-zu0ubwfq 132 31 . . NNP cord-301692-zu0ubwfq 132 32 , , , cord-301692-zu0ubwfq 132 33 2006 2006 CD cord-301692-zu0ubwfq 132 34 ) ) -RRB- cord-301692-zu0ubwfq 132 35 . . . cord-301692-zu0ubwfq 133 1 Diversity diversity NN cord-301692-zu0ubwfq 133 2 within within IN cord-301692-zu0ubwfq 133 3 a a DT cord-301692-zu0ubwfq 133 4 genotype genotype NN cord-301692-zu0ubwfq 133 5 or or CC cord-301692-zu0ubwfq 133 6 subtype subtype NN cord-301692-zu0ubwfq 133 7 can can MD cord-301692-zu0ubwfq 133 8 be be VB cord-301692-zu0ubwfq 133 9 high high JJ cord-301692-zu0ubwfq 134 1 ( ( -LRB- cord-301692-zu0ubwfq 134 2 Forsberg Forsberg NNP cord-301692-zu0ubwfq 134 3 et et NNP cord-301692-zu0ubwfq 134 4 al al NNP cord-301692-zu0ubwfq 134 5 . . . cord-301692-zu0ubwfq 135 1 , , , cord-301692-zu0ubwfq 135 2 2002 2002 CD cord-301692-zu0ubwfq 135 3 ; ; : cord-301692-zu0ubwfq 135 4 Stadejek Stadejek NNP cord-301692-zu0ubwfq 135 5 et et NNP cord-301692-zu0ubwfq 135 6 al al NNP cord-301692-zu0ubwfq 135 7 . . NNP cord-301692-zu0ubwfq 135 8 , , , cord-301692-zu0ubwfq 135 9 2002 2002 CD cord-301692-zu0ubwfq 135 10 ; ; : cord-301692-zu0ubwfq 135 11 Larochelle Larochelle NNP cord-301692-zu0ubwfq 135 12 et et NNP cord-301692-zu0ubwfq 135 13 al al NNP cord-301692-zu0ubwfq 135 14 . . NNP cord-301692-zu0ubwfq 135 15 , , , cord-301692-zu0ubwfq 135 16 2003 2003 CD cord-301692-zu0ubwfq 136 1 ; ; : cord-301692-zu0ubwfq 136 2 Mateu Mateu NNP cord-301692-zu0ubwfq 136 3 et et NNP cord-301692-zu0ubwfq 136 4 al al NNP cord-301692-zu0ubwfq 136 5 . . NNP cord-301692-zu0ubwfq 136 6 , , , cord-301692-zu0ubwfq 136 7 2003 2003 CD cord-301692-zu0ubwfq 136 8 ; ; : cord-301692-zu0ubwfq 136 9 Stadejek Stadejek NNP cord-301692-zu0ubwfq 136 10 et et NNP cord-301692-zu0ubwfq 136 11 al al NNP cord-301692-zu0ubwfq 136 12 . . NNP cord-301692-zu0ubwfq 136 13 , , , cord-301692-zu0ubwfq 136 14 2006 2006 CD cord-301692-zu0ubwfq 136 15 ) ) -RRB- cord-301692-zu0ubwfq 136 16 . . . cord-301692-zu0ubwfq 137 1 Furthermore furthermore RB cord-301692-zu0ubwfq 137 2 , , , cord-301692-zu0ubwfq 137 3 PRRSV PRRSV NNP cord-301692-zu0ubwfq 137 4 also also RB cord-301692-zu0ubwfq 137 5 demonstrates demonstrate VBZ cord-301692-zu0ubwfq 137 6 the the DT cord-301692-zu0ubwfq 137 7 phenomenon phenomenon NN cord-301692-zu0ubwfq 137 8 of of IN cord-301692-zu0ubwfq 137 9 quasispecies quasispecie NNS cord-301692-zu0ubwfq 137 10 generation generation NN cord-301692-zu0ubwfq 137 11 ( ( -LRB- cord-301692-zu0ubwfq 137 12 Rowland Rowland NNP cord-301692-zu0ubwfq 137 13 et et NNP cord-301692-zu0ubwfq 137 14 al al NNP cord-301692-zu0ubwfq 137 15 . . NNP cord-301692-zu0ubwfq 137 16 , , , cord-301692-zu0ubwfq 137 17 1999 1999 CD cord-301692-zu0ubwfq 137 18 ; ; : cord-301692-zu0ubwfq 138 1 Goldberg Goldberg NNP cord-301692-zu0ubwfq 138 2 et et NNP cord-301692-zu0ubwfq 138 3 al al NNP cord-301692-zu0ubwfq 138 4 . . NNP cord-301692-zu0ubwfq 138 5 , , , cord-301692-zu0ubwfq 138 6 2003 2003 CD cord-301692-zu0ubwfq 138 7 ) ) -RRB- cord-301692-zu0ubwfq 138 8 . . . cord-301692-zu0ubwfq 139 1 What what WP cord-301692-zu0ubwfq 139 2 is be VBZ cord-301692-zu0ubwfq 139 3 the the DT cord-301692-zu0ubwfq 139 4 impact impact NN cord-301692-zu0ubwfq 139 5 of of IN cord-301692-zu0ubwfq 139 6 this this DT cord-301692-zu0ubwfq 139 7 genetic genetic JJ cord-301692-zu0ubwfq 139 8 diversity diversity NN cord-301692-zu0ubwfq 139 9 of of IN cord-301692-zu0ubwfq 139 10 PRRSV PRRSV NNP cord-301692-zu0ubwfq 139 11 upon upon IN cord-301692-zu0ubwfq 139 12 the the DT cord-301692-zu0ubwfq 139 13 immune immune JJ cord-301692-zu0ubwfq 139 14 response response NN cord-301692-zu0ubwfq 139 15 and and CC cord-301692-zu0ubwfq 139 16 protection protection NN cord-301692-zu0ubwfq 139 17 afforded afford VBN cord-301692-zu0ubwfq 139 18 by by IN cord-301692-zu0ubwfq 139 19 vaccination vaccination NN cord-301692-zu0ubwfq 139 20 ? ? . cord-301692-zu0ubwfq 140 1 PRRS PRRS NNP cord-301692-zu0ubwfq 140 2 emerged emerge VBD cord-301692-zu0ubwfq 140 3 in in IN cord-301692-zu0ubwfq 140 4 Europe Europe NNP cord-301692-zu0ubwfq 140 5 and and CC cord-301692-zu0ubwfq 140 6 America America NNP cord-301692-zu0ubwfq 140 7 almost almost RB cord-301692-zu0ubwfq 140 8 simultaneously simultaneously RB cord-301692-zu0ubwfq 140 9 . . . cord-301692-zu0ubwfq 141 1 The the DT cord-301692-zu0ubwfq 141 2 first first JJ cord-301692-zu0ubwfq 141 3 vaccine vaccine NN cord-301692-zu0ubwfq 141 4 against against IN cord-301692-zu0ubwfq 141 5 PRRSV PRRSV NNP cord-301692-zu0ubwfq 141 6 marketed market VBD cord-301692-zu0ubwfq 141 7 internationally internationally RB cord-301692-zu0ubwfq 141 8 was be VBD cord-301692-zu0ubwfq 141 9 a a DT cord-301692-zu0ubwfq 141 10 modified modified JJ cord-301692-zu0ubwfq 141 11 live live JJ cord-301692-zu0ubwfq 141 12 vaccine vaccine NN cord-301692-zu0ubwfq 141 13 derived derive VBN cord-301692-zu0ubwfq 141 14 from from IN cord-301692-zu0ubwfq 141 15 the the DT cord-301692-zu0ubwfq 141 16 prototypic prototypic JJ cord-301692-zu0ubwfq 141 17 American american JJ cord-301692-zu0ubwfq 141 18 strain strain NN cord-301692-zu0ubwfq 141 19 VR-2332 vr-2332 NN cord-301692-zu0ubwfq 141 20 . . . cord-301692-zu0ubwfq 142 1 At at IN cord-301692-zu0ubwfq 142 2 that that DT cord-301692-zu0ubwfq 142 3 time time NN cord-301692-zu0ubwfq 142 4 , , , cord-301692-zu0ubwfq 142 5 it -PRON- PRP cord-301692-zu0ubwfq 142 6 was be VBD cord-301692-zu0ubwfq 142 7 obvious obvious JJ cord-301692-zu0ubwfq 142 8 that that IN cord-301692-zu0ubwfq 142 9 the the DT cord-301692-zu0ubwfq 142 10 genetic genetic JJ cord-301692-zu0ubwfq 142 11 diversity diversity NN cord-301692-zu0ubwfq 142 12 of of IN cord-301692-zu0ubwfq 142 13 PRRSV PRRSV NNP cord-301692-zu0ubwfq 142 14 could could MD cord-301692-zu0ubwfq 142 15 pose pose VB cord-301692-zu0ubwfq 142 16 problems problem NNS cord-301692-zu0ubwfq 142 17 regarding regard VBG cord-301692-zu0ubwfq 142 18 the the DT cord-301692-zu0ubwfq 142 19 efficacy efficacy NN cord-301692-zu0ubwfq 142 20 of of IN cord-301692-zu0ubwfq 142 21 the the DT cord-301692-zu0ubwfq 142 22 vaccine vaccine NN cord-301692-zu0ubwfq 142 23 , , , cord-301692-zu0ubwfq 142 24 particularly particularly RB cord-301692-zu0ubwfq 142 25 with with IN cord-301692-zu0ubwfq 142 26 infections infection NNS cord-301692-zu0ubwfq 142 27 by by IN cord-301692-zu0ubwfq 142 28 the the DT cord-301692-zu0ubwfq 142 29 European european JJ cord-301692-zu0ubwfq 142 30 genotype genotype NN cord-301692-zu0ubwfq 142 31 . . . cord-301692-zu0ubwfq 143 1 Pregnant pregnant JJ cord-301692-zu0ubwfq 143 2 gilts gilt NNS cord-301692-zu0ubwfq 143 3 infected infect VBN cord-301692-zu0ubwfq 143 4 with with IN cord-301692-zu0ubwfq 143 5 the the DT cord-301692-zu0ubwfq 143 6 American american JJ cord-301692-zu0ubwfq 143 7 isolate isolate VBP cord-301692-zu0ubwfq 143 8 NADC-8 NADC-8 NNS cord-301692-zu0ubwfq 143 9 and and CC cord-301692-zu0ubwfq 143 10 challenged challenge VBN cord-301692-zu0ubwfq 143 11 with with IN cord-301692-zu0ubwfq 143 12 the the DT cord-301692-zu0ubwfq 143 13 European european JJ cord-301692-zu0ubwfq 143 14 isolate isolate VBP cord-301692-zu0ubwfq 143 15 Lelystad Lelystad NNP cord-301692-zu0ubwfq 143 16 virus virus NN cord-301692-zu0ubwfq 143 17 ( ( -LRB- cord-301692-zu0ubwfq 143 18 LV LV NNP cord-301692-zu0ubwfq 143 19 ) ) -RRB- cord-301692-zu0ubwfq 144 1 late late RB cord-301692-zu0ubwfq 144 2 in in IN cord-301692-zu0ubwfq 144 3 gestation gestation NN cord-301692-zu0ubwfq 144 4 had have VBD cord-301692-zu0ubwfq 144 5 only only JJ cord-301692-zu0ubwfq 144 6 partial partial JJ cord-301692-zu0ubwfq 144 7 protection protection NN cord-301692-zu0ubwfq 144 8 against against IN cord-301692-zu0ubwfq 144 9 transplacental transplacental NNP cord-301692-zu0ubwfq 144 10 infection infection NN cord-301692-zu0ubwfq 145 1 ( ( -LRB- cord-301692-zu0ubwfq 145 2 virus virus NN cord-301692-zu0ubwfq 145 3 crossed cross VBD cord-301692-zu0ubwfq 145 4 the the DT cord-301692-zu0ubwfq 145 5 placenta placenta NN cord-301692-zu0ubwfq 145 6 in in IN cord-301692-zu0ubwfq 145 7 1/7 1/7 CD cord-301692-zu0ubwfq 145 8 gilts gilt NNS cord-301692-zu0ubwfq 145 9 ) ) -RRB- cord-301692-zu0ubwfq 145 10 , , , cord-301692-zu0ubwfq 145 11 whereas whereas IN cord-301692-zu0ubwfq 145 12 all all DT cord-301692-zu0ubwfq 145 13 gilts gilt NNS cord-301692-zu0ubwfq 145 14 challenged challenge VBD cord-301692-zu0ubwfq 145 15 with with IN cord-301692-zu0ubwfq 145 16 the the DT cord-301692-zu0ubwfq 145 17 homologous homologous JJ cord-301692-zu0ubwfq 145 18 virus virus NN cord-301692-zu0ubwfq 145 19 were be VBD cord-301692-zu0ubwfq 145 20 fully fully RB cord-301692-zu0ubwfq 145 21 protected protect VBN cord-301692-zu0ubwfq 146 1 ( ( -LRB- cord-301692-zu0ubwfq 146 2 Lager Lager NNP cord-301692-zu0ubwfq 146 3 et et NNP cord-301692-zu0ubwfq 146 4 al al NNP cord-301692-zu0ubwfq 146 5 . . NNP cord-301692-zu0ubwfq 146 6 , , , cord-301692-zu0ubwfq 146 7 1999 1999 CD cord-301692-zu0ubwfq 146 8 ) ) -RRB- cord-301692-zu0ubwfq 146 9 . . . cord-301692-zu0ubwfq 147 1 These these DT cord-301692-zu0ubwfq 147 2 results result NNS cord-301692-zu0ubwfq 147 3 showed show VBD cord-301692-zu0ubwfq 147 4 that that IN cord-301692-zu0ubwfq 147 5 heterologous heterologous NNP cord-301692-zu0ubwfq 147 6 protection protection NN cord-301692-zu0ubwfq 147 7 existed exist VBD cord-301692-zu0ubwfq 147 8 , , , cord-301692-zu0ubwfq 147 9 but but CC cord-301692-zu0ubwfq 147 10 was be VBD cord-301692-zu0ubwfq 147 11 only only RB cord-301692-zu0ubwfq 147 12 partial partial JJ cord-301692-zu0ubwfq 147 13 , , , cord-301692-zu0ubwfq 147 14 and and CC cord-301692-zu0ubwfq 147 15 suggested suggest VBD cord-301692-zu0ubwfq 147 16 that that IN cord-301692-zu0ubwfq 147 17 common common JJ cord-301692-zu0ubwfq 147 18 epitopes epitope NNS cord-301692-zu0ubwfq 147 19 are be VBP cord-301692-zu0ubwfq 147 20 likely likely JJ cord-301692-zu0ubwfq 147 21 to to TO cord-301692-zu0ubwfq 147 22 be be VB cord-301692-zu0ubwfq 147 23 involved involve VBN cord-301692-zu0ubwfq 147 24 in in IN cord-301692-zu0ubwfq 147 25 protection protection NN cord-301692-zu0ubwfq 147 26 in in IN cord-301692-zu0ubwfq 147 27 both both CC cord-301692-zu0ubwfq 147 28 European european JJ cord-301692-zu0ubwfq 147 29 and and CC cord-301692-zu0ubwfq 147 30 American american JJ cord-301692-zu0ubwfq 147 31 - - HYPH cord-301692-zu0ubwfq 147 32 type type NN cord-301692-zu0ubwfq 147 33 strains strain NNS cord-301692-zu0ubwfq 147 34 . . . cord-301692-zu0ubwfq 148 1 Furthermore furthermore RB cord-301692-zu0ubwfq 148 2 , , , cord-301692-zu0ubwfq 148 3 monoclonal monoclonal JJ cord-301692-zu0ubwfq 148 4 antibodies antibody NNS cord-301692-zu0ubwfq 148 5 against against IN cord-301692-zu0ubwfq 148 6 the the DT cord-301692-zu0ubwfq 148 7 neutralising neutralise VBG cord-301692-zu0ubwfq 148 8 epitope epitope NN cord-301692-zu0ubwfq 148 9 of of IN cord-301692-zu0ubwfq 148 10 the the DT cord-301692-zu0ubwfq 148 11 related related JJ cord-301692-zu0ubwfq 148 12 virus virus NN cord-301692-zu0ubwfq 148 13 LDV LDV NNP cord-301692-zu0ubwfq 148 14 are be VBP cord-301692-zu0ubwfq 148 15 able able JJ cord-301692-zu0ubwfq 148 16 to to TO cord-301692-zu0ubwfq 148 17 neutralise neutralise VB cord-301692-zu0ubwfq 148 18 both both DT cord-301692-zu0ubwfq 148 19 VR-2332 vr-2332 NN cord-301692-zu0ubwfq 148 20 and and CC cord-301692-zu0ubwfq 148 21 LV LV NNP cord-301692-zu0ubwfq 148 22 , , , cord-301692-zu0ubwfq 148 23 indicating indicate VBG cord-301692-zu0ubwfq 148 24 that that IN cord-301692-zu0ubwfq 148 25 the the DT cord-301692-zu0ubwfq 148 26 neutralising neutralise VBG cord-301692-zu0ubwfq 148 27 epitope epitope NN cord-301692-zu0ubwfq 148 28 in in IN cord-301692-zu0ubwfq 148 29 GP5 GP5 NNP cord-301692-zu0ubwfq 148 30 is be VBZ cord-301692-zu0ubwfq 148 31 shared share VBN cord-301692-zu0ubwfq 148 32 to to IN cord-301692-zu0ubwfq 148 33 some some DT cord-301692-zu0ubwfq 148 34 extent extent NN cord-301692-zu0ubwfq 148 35 by by IN cord-301692-zu0ubwfq 148 36 diverse diverse JJ cord-301692-zu0ubwfq 148 37 arteriviruses arteriviruse NNS cord-301692-zu0ubwfq 149 1 ( ( -LRB- cord-301692-zu0ubwfq 149 2 Plagemann Plagemann NNP cord-301692-zu0ubwfq 149 3 et et FW cord-301692-zu0ubwfq 149 4 al al NNP cord-301692-zu0ubwfq 149 5 . . NNP cord-301692-zu0ubwfq 149 6 , , , cord-301692-zu0ubwfq 149 7 2002 2002 CD cord-301692-zu0ubwfq 149 8 ) ) -RRB- cord-301692-zu0ubwfq 150 1 Although although IN cord-301692-zu0ubwfq 150 2 partial partial JJ cord-301692-zu0ubwfq 150 3 heterologous heterologous JJ cord-301692-zu0ubwfq 150 4 protection protection NN cord-301692-zu0ubwfq 150 5 might may MD cord-301692-zu0ubwfq 150 6 be be VB cord-301692-zu0ubwfq 150 7 beneficial beneficial JJ cord-301692-zu0ubwfq 150 8 under under IN cord-301692-zu0ubwfq 150 9 some some DT cord-301692-zu0ubwfq 150 10 circumstances circumstance NNS cord-301692-zu0ubwfq 150 11 , , , cord-301692-zu0ubwfq 150 12 a a DT cord-301692-zu0ubwfq 150 13 genotype genotype NN cord-301692-zu0ubwfq 150 14 - - HYPH cord-301692-zu0ubwfq 150 15 based base VBN cord-301692-zu0ubwfq 150 16 vaccine vaccine NN cord-301692-zu0ubwfq 150 17 is be VBZ cord-301692-zu0ubwfq 150 18 insufficient insufficient JJ cord-301692-zu0ubwfq 150 19 to to TO cord-301692-zu0ubwfq 150 20 produce produce VB cord-301692-zu0ubwfq 150 21 immunising immunise VBG cord-301692-zu0ubwfq 150 22 sterility sterility NN cord-301692-zu0ubwfq 150 23 . . . cord-301692-zu0ubwfq 151 1 Given give VBN cord-301692-zu0ubwfq 151 2 the the DT cord-301692-zu0ubwfq 151 3 genetic genetic JJ cord-301692-zu0ubwfq 151 4 diversity diversity NN cord-301692-zu0ubwfq 151 5 of of IN cord-301692-zu0ubwfq 151 6 the the DT cord-301692-zu0ubwfq 151 7 virus virus NN cord-301692-zu0ubwfq 151 8 within within IN cord-301692-zu0ubwfq 151 9 one one CD cord-301692-zu0ubwfq 151 10 genotype genotype NN cord-301692-zu0ubwfq 151 11 , , , cord-301692-zu0ubwfq 151 12 the the DT cord-301692-zu0ubwfq 151 13 question question NN cord-301692-zu0ubwfq 151 14 then then RB cord-301692-zu0ubwfq 151 15 was be VBD cord-301692-zu0ubwfq 151 16 whether whether IN cord-301692-zu0ubwfq 151 17 this this DT cord-301692-zu0ubwfq 151 18 phenomenon phenomenon NN cord-301692-zu0ubwfq 151 19 might may MD cord-301692-zu0ubwfq 151 20 influence influence VB cord-301692-zu0ubwfq 151 21 the the DT cord-301692-zu0ubwfq 151 22 efficacy efficacy NN cord-301692-zu0ubwfq 151 23 of of IN cord-301692-zu0ubwfq 151 24 a a DT cord-301692-zu0ubwfq 151 25 homologous homologous JJ cord-301692-zu0ubwfq 151 26 vaccine vaccine NN cord-301692-zu0ubwfq 151 27 . . . cord-301692-zu0ubwfq 152 1 Piglets piglet NNS cord-301692-zu0ubwfq 152 2 vaccinated vaccinate VBN cord-301692-zu0ubwfq 152 3 with with IN cord-301692-zu0ubwfq 152 4 attenuated attenuated JJ cord-301692-zu0ubwfq 152 5 versions version NNS cord-301692-zu0ubwfq 152 6 of of IN cord-301692-zu0ubwfq 152 7 American american JJ cord-301692-zu0ubwfq 152 8 strains strain NNS cord-301692-zu0ubwfq 152 9 NADC-8 NADC-8 NNS cord-301692-zu0ubwfq 152 10 , , , cord-301692-zu0ubwfq 152 11 9 9 CD cord-301692-zu0ubwfq 152 12 or or CC cord-301692-zu0ubwfq 152 13 14 14 CD cord-301692-zu0ubwfq 152 14 were be VBD cord-301692-zu0ubwfq 152 15 challenged challenge VBN cord-301692-zu0ubwfq 152 16 21 21 CD cord-301692-zu0ubwfq 152 17 days day NNS cord-301692-zu0ubwfq 152 18 later later RB cord-301692-zu0ubwfq 152 19 with with IN cord-301692-zu0ubwfq 152 20 a a DT cord-301692-zu0ubwfq 152 21 mixture mixture NN cord-301692-zu0ubwfq 152 22 of of IN cord-301692-zu0ubwfq 152 23 the the DT cord-301692-zu0ubwfq 152 24 virulent virulent JJ cord-301692-zu0ubwfq 152 25 versions version NNS cord-301692-zu0ubwfq 152 26 of of IN cord-301692-zu0ubwfq 152 27 the the DT cord-301692-zu0ubwfq 152 28 same same JJ cord-301692-zu0ubwfq 152 29 strains strain NNS cord-301692-zu0ubwfq 152 30 ( ( -LRB- cord-301692-zu0ubwfq 152 31 Mengeling Mengeling NNP cord-301692-zu0ubwfq 152 32 et et FW cord-301692-zu0ubwfq 152 33 al al NNP cord-301692-zu0ubwfq 152 34 . . NNP cord-301692-zu0ubwfq 152 35 , , , cord-301692-zu0ubwfq 152 36 2003 2003 CD cord-301692-zu0ubwfq 152 37 ) ) -RRB- cord-301692-zu0ubwfq 152 38 . . . cord-301692-zu0ubwfq 153 1 A a DT cord-301692-zu0ubwfq 153 2 given give VBN cord-301692-zu0ubwfq 153 3 virulent virulent JJ cord-301692-zu0ubwfq 153 4 strain strain NN cord-301692-zu0ubwfq 153 5 was be VBD cord-301692-zu0ubwfq 153 6 not not RB cord-301692-zu0ubwfq 153 7 present present JJ cord-301692-zu0ubwfq 153 8 after after IN cord-301692-zu0ubwfq 153 9 challenge challenge NN cord-301692-zu0ubwfq 153 10 if if IN cord-301692-zu0ubwfq 153 11 the the DT cord-301692-zu0ubwfq 153 12 piglets piglet NNS cord-301692-zu0ubwfq 153 13 had have VBD cord-301692-zu0ubwfq 153 14 previously previously RB cord-301692-zu0ubwfq 153 15 received receive VBN cord-301692-zu0ubwfq 153 16 the the DT cord-301692-zu0ubwfq 153 17 attenuated attenuated JJ cord-301692-zu0ubwfq 153 18 version version NN cord-301692-zu0ubwfq 153 19 of of IN cord-301692-zu0ubwfq 153 20 that that DT cord-301692-zu0ubwfq 153 21 strain strain NN cord-301692-zu0ubwfq 153 22 , , , cord-301692-zu0ubwfq 153 23 whereas whereas IN cord-301692-zu0ubwfq 153 24 infections infection NNS cord-301692-zu0ubwfq 153 25 with with IN cord-301692-zu0ubwfq 153 26 the the DT cord-301692-zu0ubwfq 153 27 other other JJ cord-301692-zu0ubwfq 153 28 virulent virulent JJ cord-301692-zu0ubwfq 153 29 strains strain NNS cord-301692-zu0ubwfq 153 30 were be VBD cord-301692-zu0ubwfq 153 31 established establish VBN cord-301692-zu0ubwfq 153 32 , , , cord-301692-zu0ubwfq 153 33 indicating indicate VBG cord-301692-zu0ubwfq 153 34 that that IN cord-301692-zu0ubwfq 153 35 immunity immunity NN cord-301692-zu0ubwfq 153 36 to to IN cord-301692-zu0ubwfq 153 37 PRRSV PRRSV NNP cord-301692-zu0ubwfq 153 38 may may MD cord-301692-zu0ubwfq 153 39 be be VB cord-301692-zu0ubwfq 153 40 strain strain NN cord-301692-zu0ubwfq 153 41 - - HYPH cord-301692-zu0ubwfq 153 42 related relate VBN cord-301692-zu0ubwfq 153 43 . . . cord-301692-zu0ubwfq 154 1 After after IN cord-301692-zu0ubwfq 154 2 vaccination vaccination NN cord-301692-zu0ubwfq 154 3 with with IN cord-301692-zu0ubwfq 154 4 a a DT cord-301692-zu0ubwfq 154 5 European european JJ cord-301692-zu0ubwfq 154 6 - - HYPH cord-301692-zu0ubwfq 154 7 type type NN cord-301692-zu0ubwfq 154 8 modified modify VBN cord-301692-zu0ubwfq 154 9 live live JJ cord-301692-zu0ubwfq 154 10 vaccine vaccine NN cord-301692-zu0ubwfq 154 11 , , , cord-301692-zu0ubwfq 154 12 pigs pig NNS cord-301692-zu0ubwfq 154 13 were be VBD cord-301692-zu0ubwfq 154 14 mostly mostly RB cord-301692-zu0ubwfq 154 15 negative negative JJ cord-301692-zu0ubwfq 154 16 for for IN cord-301692-zu0ubwfq 154 17 virus virus NN cord-301692-zu0ubwfq 154 18 in in IN cord-301692-zu0ubwfq 154 19 serum serum NN cord-301692-zu0ubwfq 154 20 or or CC cord-301692-zu0ubwfq 154 21 BAL bal NN cord-301692-zu0ubwfq 154 22 fluid fluid NN cord-301692-zu0ubwfq 154 23 after after IN cord-301692-zu0ubwfq 154 24 challenge challenge NN cord-301692-zu0ubwfq 154 25 with with IN cord-301692-zu0ubwfq 154 26 LV LV NNP cord-301692-zu0ubwfq 155 1 ( ( -LRB- cord-301692-zu0ubwfq 155 2 Labarque Labarque NNP cord-301692-zu0ubwfq 155 3 et et FW cord-301692-zu0ubwfq 155 4 al al NNP cord-301692-zu0ubwfq 155 5 . . NNP cord-301692-zu0ubwfq 155 6 , , , cord-301692-zu0ubwfq 155 7 2004 2004 CD cord-301692-zu0ubwfq 155 8 ) ) -RRB- cord-301692-zu0ubwfq 156 1 In in IN cord-301692-zu0ubwfq 156 2 contrast contrast NN cord-301692-zu0ubwfq 156 3 , , , cord-301692-zu0ubwfq 156 4 vaccinated vaccinated JJ cord-301692-zu0ubwfq 156 5 pigs pig NNS cord-301692-zu0ubwfq 156 6 developed develop VBD cord-301692-zu0ubwfq 156 7 viraemia viraemia NN cord-301692-zu0ubwfq 156 8 over over IN cord-301692-zu0ubwfq 156 9 15 15 CD cord-301692-zu0ubwfq 156 10 days day NNS cord-301692-zu0ubwfq 156 11 and and CC cord-301692-zu0ubwfq 156 12 were be VBD cord-301692-zu0ubwfq 156 13 positive positive JJ cord-301692-zu0ubwfq 156 14 for for IN cord-301692-zu0ubwfq 156 15 virus virus NN cord-301692-zu0ubwfq 156 16 in in IN cord-301692-zu0ubwfq 156 17 BAL bal NN cord-301692-zu0ubwfq 156 18 fluid fluid NN cord-301692-zu0ubwfq 156 19 when when WRB cord-301692-zu0ubwfq 156 20 challenged challenge VBN cord-301692-zu0ubwfq 156 21 with with IN cord-301692-zu0ubwfq 156 22 an an DT cord-301692-zu0ubwfq 156 23 Italian italian JJ cord-301692-zu0ubwfq 156 24 variant variant NN cord-301692-zu0ubwfq 156 25 strain strain NN cord-301692-zu0ubwfq 156 26 that that WDT cord-301692-zu0ubwfq 156 27 had have VBD cord-301692-zu0ubwfq 156 28 84 84 CD cord-301692-zu0ubwfq 156 29 % % NN cord-301692-zu0ubwfq 156 30 similarity similarity NN cord-301692-zu0ubwfq 156 31 in in IN cord-301692-zu0ubwfq 156 32 ORF5 ORF5 NNP cord-301692-zu0ubwfq 156 33 to to IN cord-301692-zu0ubwfq 156 34 the the DT cord-301692-zu0ubwfq 156 35 vaccine vaccine NN cord-301692-zu0ubwfq 156 36 strain strain NN cord-301692-zu0ubwfq 156 37 . . . cord-301692-zu0ubwfq 157 1 Protection protection NN cord-301692-zu0ubwfq 157 2 against against IN cord-301692-zu0ubwfq 157 3 PRRSV PRRSV NNP cord-301692-zu0ubwfq 157 4 infection infection NN cord-301692-zu0ubwfq 157 5 by by IN cord-301692-zu0ubwfq 157 6 a a DT cord-301692-zu0ubwfq 157 7 strain strain NN cord-301692-zu0ubwfq 157 8 different different JJ cord-301692-zu0ubwfq 157 9 to to IN cord-301692-zu0ubwfq 157 10 the the DT cord-301692-zu0ubwfq 157 11 one one NN cord-301692-zu0ubwfq 157 12 used use VBN cord-301692-zu0ubwfq 157 13 as as IN cord-301692-zu0ubwfq 157 14 a a DT cord-301692-zu0ubwfq 157 15 vaccine vaccine NN cord-301692-zu0ubwfq 157 16 is be VBZ cord-301692-zu0ubwfq 157 17 somewhat somewhat RB cord-301692-zu0ubwfq 157 18 more more RBR cord-301692-zu0ubwfq 157 19 complex complex JJ cord-301692-zu0ubwfq 157 20 than than IN cord-301692-zu0ubwfq 157 21 a a DT cord-301692-zu0ubwfq 157 22 matter matter NN cord-301692-zu0ubwfq 157 23 of of IN cord-301692-zu0ubwfq 157 24 genetic genetic JJ cord-301692-zu0ubwfq 157 25 similarity similarity NN cord-301692-zu0ubwfq 157 26 . . . cord-301692-zu0ubwfq 158 1 Pigs pig NNS cord-301692-zu0ubwfq 158 2 were be VBD cord-301692-zu0ubwfq 158 3 vaccinated vaccinate VBN cord-301692-zu0ubwfq 158 4 with with IN cord-301692-zu0ubwfq 158 5 two two CD cord-301692-zu0ubwfq 158 6 different different JJ cord-301692-zu0ubwfq 158 7 European european JJ cord-301692-zu0ubwfq 158 8 - - HYPH cord-301692-zu0ubwfq 158 9 type type NN cord-301692-zu0ubwfq 158 10 vaccines vaccine NNS cord-301692-zu0ubwfq 158 11 ( ( -LRB- cord-301692-zu0ubwfq 158 12 v1 v1 NN cord-301692-zu0ubwfq 158 13 and and CC cord-301692-zu0ubwfq 158 14 v3 v3 NNP cord-301692-zu0ubwfq 158 15 ) ) -RRB- cord-301692-zu0ubwfq 158 16 , , , cord-301692-zu0ubwfq 158 17 then then RB cord-301692-zu0ubwfq 158 18 challenged challenge VBD cord-301692-zu0ubwfq 158 19 with with IN cord-301692-zu0ubwfq 158 20 a a DT cord-301692-zu0ubwfq 158 21 strain strain NN cord-301692-zu0ubwfq 158 22 similar similar JJ cord-301692-zu0ubwfq 158 23 to to IN cord-301692-zu0ubwfq 158 24 one one CD cord-301692-zu0ubwfq 158 25 of of IN cord-301692-zu0ubwfq 158 26 the the DT cord-301692-zu0ubwfq 158 27 vaccines vaccine NNS cord-301692-zu0ubwfq 158 28 and and CC cord-301692-zu0ubwfq 158 29 slightly slightly RB cord-301692-zu0ubwfq 158 30 different different JJ cord-301692-zu0ubwfq 158 31 to to IN cord-301692-zu0ubwfq 158 32 the the DT cord-301692-zu0ubwfq 158 33 other other JJ cord-301692-zu0ubwfq 158 34 ( ( -LRB- cord-301692-zu0ubwfq 158 35 92 92 CD cord-301692-zu0ubwfq 158 36 - - SYM cord-301692-zu0ubwfq 158 37 96 96 CD cord-301692-zu0ubwfq 158 38 % % NN cord-301692-zu0ubwfq 158 39 similarity similarity NN cord-301692-zu0ubwfq 158 40 ) ) -RRB- cord-301692-zu0ubwfq 159 1 ( ( -LRB- cord-301692-zu0ubwfq 159 2 Diaz Diaz NNP cord-301692-zu0ubwfq 159 3 et et NNP cord-301692-zu0ubwfq 159 4 al al NNP cord-301692-zu0ubwfq 159 5 . . NNP cord-301692-zu0ubwfq 159 6 , , , cord-301692-zu0ubwfq 159 7 2006 2006 CD cord-301692-zu0ubwfq 159 8 ) ) -RRB- cord-301692-zu0ubwfq 159 9 . . . cord-301692-zu0ubwfq 160 1 Surprisingly surprisingly RB cord-301692-zu0ubwfq 160 2 , , , cord-301692-zu0ubwfq 160 3 the the DT cord-301692-zu0ubwfq 160 4 ' ' `` cord-301692-zu0ubwfq 160 5 ' ' `` cord-301692-zu0ubwfq 160 6 heterologous heterologous NNP cord-301692-zu0ubwfq 160 7 ' ' '' cord-301692-zu0ubwfq 160 8 ' ' '' cord-301692-zu0ubwfq 160 9 v3 v3 NNP cord-301692-zu0ubwfq 160 10 vaccine vaccine NN cord-301692-zu0ubwfq 160 11 afforded afford VBD cord-301692-zu0ubwfq 160 12 sterilising sterilise VBG cord-301692-zu0ubwfq 160 13 immunity immunity NN cord-301692-zu0ubwfq 160 14 , , , cord-301692-zu0ubwfq 160 15 while while IN cord-301692-zu0ubwfq 160 16 the the DT cord-301692-zu0ubwfq 160 17 homologous homologous JJ cord-301692-zu0ubwfq 160 18 v1 v1 NN cord-301692-zu0ubwfq 160 19 vaccine vaccine NN cord-301692-zu0ubwfq 160 20 did do VBD cord-301692-zu0ubwfq 160 21 not not RB cord-301692-zu0ubwfq 160 22 . . . cord-301692-zu0ubwfq 161 1 The the DT cord-301692-zu0ubwfq 161 2 v3 v3 NNP cord-301692-zu0ubwfq 161 3 vaccine vaccine NN cord-301692-zu0ubwfq 161 4 induced induce VBD cord-301692-zu0ubwfq 161 5 higher high JJR cord-301692-zu0ubwfq 161 6 levels level NNS cord-301692-zu0ubwfq 161 7 of of IN cord-301692-zu0ubwfq 161 8 IFN IFN NNP cord-301692-zu0ubwfq 161 9 - - HYPH cord-301692-zu0ubwfq 161 10 c c NNP cord-301692-zu0ubwfq 161 11 secreting secreting NN cord-301692-zu0ubwfq 161 12 cells cell NNS cord-301692-zu0ubwfq 161 13 , , , cord-301692-zu0ubwfq 161 14 whereas whereas IN cord-301692-zu0ubwfq 161 15 v1 v1 NN cord-301692-zu0ubwfq 161 16 induced induce VBN cord-301692-zu0ubwfq 161 17 IL-10 IL-10 NNP cord-301692-zu0ubwfq 161 18 release release NN cord-301692-zu0ubwfq 161 19 by by IN cord-301692-zu0ubwfq 161 20 PMBCs pmbc NNS cord-301692-zu0ubwfq 161 21 . . . cord-301692-zu0ubwfq 162 1 The the DT cord-301692-zu0ubwfq 162 2 ability ability NN cord-301692-zu0ubwfq 162 3 of of IN cord-301692-zu0ubwfq 162 4 each each DT cord-301692-zu0ubwfq 162 5 strain strain NN cord-301692-zu0ubwfq 162 6 to to TO cord-301692-zu0ubwfq 162 7 induce induce VB cord-301692-zu0ubwfq 162 8 a a DT cord-301692-zu0ubwfq 162 9 strong strong JJ cord-301692-zu0ubwfq 162 10 cell cell NN cord-301692-zu0ubwfq 162 11 - - HYPH cord-301692-zu0ubwfq 162 12 mediated mediate VBN cord-301692-zu0ubwfq 162 13 immune immune JJ cord-301692-zu0ubwfq 162 14 response response NN cord-301692-zu0ubwfq 162 15 was be VBD cord-301692-zu0ubwfq 162 16 more more RBR cord-301692-zu0ubwfq 162 17 important important JJ cord-301692-zu0ubwfq 162 18 that that IN cord-301692-zu0ubwfq 162 19 the the DT cord-301692-zu0ubwfq 162 20 genetic genetic JJ cord-301692-zu0ubwfq 162 21 similarity similarity NN cord-301692-zu0ubwfq 162 22 inducing induce VBG cord-301692-zu0ubwfq 162 23 protection protection NN cord-301692-zu0ubwfq 162 24 . . . cord-301692-zu0ubwfq 163 1 The the DT cord-301692-zu0ubwfq 163 2 complexity complexity NN cord-301692-zu0ubwfq 163 3 of of IN cord-301692-zu0ubwfq 163 4 the the DT cord-301692-zu0ubwfq 163 5 immune immune JJ cord-301692-zu0ubwfq 163 6 response response NN cord-301692-zu0ubwfq 163 7 to to IN cord-301692-zu0ubwfq 163 8 PRRSV PRRSV NNP cord-301692-zu0ubwfq 163 9 and and CC cord-301692-zu0ubwfq 163 10 the the DT cord-301692-zu0ubwfq 163 11 ability ability NN cord-301692-zu0ubwfq 163 12 of of IN cord-301692-zu0ubwfq 163 13 the the DT cord-301692-zu0ubwfq 163 14 virus virus NN cord-301692-zu0ubwfq 163 15 to to TO cord-301692-zu0ubwfq 163 16 escape escape VB cord-301692-zu0ubwfq 163 17 or or CC cord-301692-zu0ubwfq 163 18 modulate modulate VB cord-301692-zu0ubwfq 163 19 the the DT cord-301692-zu0ubwfq 163 20 host host NN cord-301692-zu0ubwfq 163 21 's 's POS cord-301692-zu0ubwfq 163 22 immune immune JJ cord-301692-zu0ubwfq 163 23 system system NN cord-301692-zu0ubwfq 163 24 make make VBP cord-301692-zu0ubwfq 163 25 it -PRON- PRP cord-301692-zu0ubwfq 163 26 difficult difficult JJ cord-301692-zu0ubwfq 163 27 to to TO cord-301692-zu0ubwfq 163 28 develop develop VB cord-301692-zu0ubwfq 163 29 a a DT cord-301692-zu0ubwfq 163 30 vaccine vaccine NN cord-301692-zu0ubwfq 163 31 that that WDT cord-301692-zu0ubwfq 163 32 can can MD cord-301692-zu0ubwfq 163 33 be be VB cord-301692-zu0ubwfq 163 34 used use VBN cord-301692-zu0ubwfq 163 35 to to TO cord-301692-zu0ubwfq 163 36 eradicate eradicate VB cord-301692-zu0ubwfq 163 37 the the DT cord-301692-zu0ubwfq 163 38 disease disease NN cord-301692-zu0ubwfq 163 39 . . . cord-301692-zu0ubwfq 164 1 Such such JJ cord-301692-zu0ubwfq 164 2 a a DT cord-301692-zu0ubwfq 164 3 vaccine vaccine NN cord-301692-zu0ubwfq 164 4 should should MD cord-301692-zu0ubwfq 164 5 accomplish accomplish VB cord-301692-zu0ubwfq 164 6 at at RB cord-301692-zu0ubwfq 164 7 least least JJS cord-301692-zu0ubwfq 164 8 four four CD cord-301692-zu0ubwfq 164 9 requirements requirement NNS cord-301692-zu0ubwfq 164 10 : : : cord-301692-zu0ubwfq 164 11 efficacy efficacy NN cord-301692-zu0ubwfq 164 12 , , , cord-301692-zu0ubwfq 164 13 universality universality NN cord-301692-zu0ubwfq 164 14 , , , cord-301692-zu0ubwfq 164 15 safety safety NN cord-301692-zu0ubwfq 164 16 and and CC cord-301692-zu0ubwfq 164 17 ability ability NN cord-301692-zu0ubwfq 164 18 to to TO cord-301692-zu0ubwfq 164 19 differentiate differentiate VB cord-301692-zu0ubwfq 164 20 vaccinated vaccinate VBN cord-301692-zu0ubwfq 164 21 from from IN cord-301692-zu0ubwfq 164 22 infected infected JJ cord-301692-zu0ubwfq 164 23 animals animal NNS cord-301692-zu0ubwfq 164 24 . . . cord-301692-zu0ubwfq 165 1 The the DT cord-301692-zu0ubwfq 165 2 first first JJ cord-301692-zu0ubwfq 165 3 line line NN cord-301692-zu0ubwfq 165 4 of of IN cord-301692-zu0ubwfq 165 5 investigation investigation NN cord-301692-zu0ubwfq 165 6 is be VBZ cord-301692-zu0ubwfq 165 7 the the DT cord-301692-zu0ubwfq 165 8 detailed detailed JJ cord-301692-zu0ubwfq 165 9 investigation investigation NN cord-301692-zu0ubwfq 165 10 of of IN cord-301692-zu0ubwfq 165 11 B B NNP cord-301692-zu0ubwfq 165 12 and and CC cord-301692-zu0ubwfq 165 13 T T NNP cord-301692-zu0ubwfq 165 14 cell cell NN cord-301692-zu0ubwfq 165 15 epitopes epitope NNS cord-301692-zu0ubwfq 165 16 involved involve VBN cord-301692-zu0ubwfq 165 17 in in IN cord-301692-zu0ubwfq 165 18 the the DT cord-301692-zu0ubwfq 165 19 development development NN cord-301692-zu0ubwfq 165 20 of of IN cord-301692-zu0ubwfq 165 21 protective protective JJ cord-301692-zu0ubwfq 165 22 immunity immunity NN cord-301692-zu0ubwfq 165 23 . . . cord-301692-zu0ubwfq 166 1 Neutralising neutralising NN cord-301692-zu0ubwfq 166 2 epitopes epitope NNS cord-301692-zu0ubwfq 166 3 have have VBP cord-301692-zu0ubwfq 166 4 been be VBN cord-301692-zu0ubwfq 166 5 established establish VBN cord-301692-zu0ubwfq 166 6 definitively definitively RB cord-301692-zu0ubwfq 166 7 . . . cord-301692-zu0ubwfq 167 1 Little little JJ cord-301692-zu0ubwfq 167 2 is be VBZ cord-301692-zu0ubwfq 167 3 known know VBN cord-301692-zu0ubwfq 167 4 regarding regard VBG cord-301692-zu0ubwfq 167 5 T T NNP cord-301692-zu0ubwfq 167 6 cell cell NN cord-301692-zu0ubwfq 167 7 epitopes epitope NNS cord-301692-zu0ubwfq 167 8 , , , cord-301692-zu0ubwfq 167 9 although although IN cord-301692-zu0ubwfq 167 10 T T NNP cord-301692-zu0ubwfq 167 11 cell cell NN cord-301692-zu0ubwfq 167 12 responses response NNS cord-301692-zu0ubwfq 167 13 to to IN cord-301692-zu0ubwfq 167 14 individual individual JJ cord-301692-zu0ubwfq 167 15 PRRSV PRRSV NNP cord-301692-zu0ubwfq 167 16 polypeptides polypeptide NNS cord-301692-zu0ubwfq 167 17 have have VBP cord-301692-zu0ubwfq 167 18 been be VBN cord-301692-zu0ubwfq 167 19 reported report VBN cord-301692-zu0ubwfq 167 20 in in IN cord-301692-zu0ubwfq 167 21 virusinfected virusinfecte VBN cord-301692-zu0ubwfq 167 22 animals animal NNS cord-301692-zu0ubwfq 167 23 ( ( -LRB- cord-301692-zu0ubwfq 168 1 Bautista Bautista NNP cord-301692-zu0ubwfq 168 2 et et NNP cord-301692-zu0ubwfq 168 3 al al NNP cord-301692-zu0ubwfq 168 4 . . NNP cord-301692-zu0ubwfq 168 5 , , , cord-301692-zu0ubwfq 168 6 1999 1999 CD cord-301692-zu0ubwfq 168 7 ) ) -RRB- cord-301692-zu0ubwfq 168 8 . . . cord-301692-zu0ubwfq 169 1 Common common JJ cord-301692-zu0ubwfq 169 2 critical critical JJ cord-301692-zu0ubwfq 169 3 epitopes epitope NNS cord-301692-zu0ubwfq 169 4 in in IN cord-301692-zu0ubwfq 169 5 both both CC cord-301692-zu0ubwfq 169 6 European european JJ cord-301692-zu0ubwfq 169 7 and and CC cord-301692-zu0ubwfq 169 8 American american JJ cord-301692-zu0ubwfq 169 9 strains strain NNS cord-301692-zu0ubwfq 169 10 of of IN cord-301692-zu0ubwfq 169 11 PRRSV PRRSV NNP cord-301692-zu0ubwfq 169 12 have have VBP cord-301692-zu0ubwfq 169 13 to to TO cord-301692-zu0ubwfq 169 14 be be VB cord-301692-zu0ubwfq 169 15 clearly clearly RB cord-301692-zu0ubwfq 169 16 identified identify VBN cord-301692-zu0ubwfq 169 17 to to TO cord-301692-zu0ubwfq 169 18 support support VB cord-301692-zu0ubwfq 169 19 the the DT cord-301692-zu0ubwfq 169 20 development development NN cord-301692-zu0ubwfq 169 21 of of IN cord-301692-zu0ubwfq 169 22 universal universal JJ cord-301692-zu0ubwfq 169 23 vaccines vaccine NNS cord-301692-zu0ubwfq 169 24 . . . cord-301692-zu0ubwfq 170 1 The the DT cord-301692-zu0ubwfq 170 2 second second JJ cord-301692-zu0ubwfq 170 3 line line NN cord-301692-zu0ubwfq 170 4 of of IN cord-301692-zu0ubwfq 170 5 research research NN cord-301692-zu0ubwfq 170 6 is be VBZ cord-301692-zu0ubwfq 170 7 to to TO cord-301692-zu0ubwfq 170 8 determine determine VB cord-301692-zu0ubwfq 170 9 which which WDT cord-301692-zu0ubwfq 170 10 components component NNS cord-301692-zu0ubwfq 170 11 of of IN cord-301692-zu0ubwfq 170 12 the the DT cord-301692-zu0ubwfq 170 13 virion virion NN cord-301692-zu0ubwfq 170 14 or or CC cord-301692-zu0ubwfq 170 15 viral viral JJ cord-301692-zu0ubwfq 170 16 genome genome NN cord-301692-zu0ubwfq 170 17 are be VBP cord-301692-zu0ubwfq 170 18 involved involve VBN cord-301692-zu0ubwfq 170 19 in in IN cord-301692-zu0ubwfq 170 20 the the DT cord-301692-zu0ubwfq 170 21 down down JJ cord-301692-zu0ubwfq 170 22 - - HYPH cord-301692-zu0ubwfq 170 23 regulation regulation NN cord-301692-zu0ubwfq 170 24 or or CC cord-301692-zu0ubwfq 170 25 modulation modulation NN cord-301692-zu0ubwfq 170 26 of of IN cord-301692-zu0ubwfq 170 27 the the DT cord-301692-zu0ubwfq 170 28 host host NN cord-301692-zu0ubwfq 170 29 's 's POS cord-301692-zu0ubwfq 170 30 immune immune JJ cord-301692-zu0ubwfq 170 31 system system NN cord-301692-zu0ubwfq 170 32 and and CC cord-301692-zu0ubwfq 170 33 the the DT cord-301692-zu0ubwfq 170 34 mechanisms mechanism NNS cord-301692-zu0ubwfq 170 35 by by IN cord-301692-zu0ubwfq 170 36 which which WDT cord-301692-zu0ubwfq 170 37 this this DT cord-301692-zu0ubwfq 170 38 occurs occur VBZ cord-301692-zu0ubwfq 170 39 . . . cord-301692-zu0ubwfq 171 1 This this DT cord-301692-zu0ubwfq 171 2 is be VBZ cord-301692-zu0ubwfq 171 3 critical critical JJ cord-301692-zu0ubwfq 171 4 for for IN cord-301692-zu0ubwfq 171 5 development development NN cord-301692-zu0ubwfq 171 6 of of IN cord-301692-zu0ubwfq 171 7 a a DT cord-301692-zu0ubwfq 171 8 live live JJ cord-301692-zu0ubwfq 171 9 attenuated attenuated JJ cord-301692-zu0ubwfq 171 10 vaccine vaccine NN cord-301692-zu0ubwfq 171 11 . . . cord-301692-zu0ubwfq 172 1 The the DT cord-301692-zu0ubwfq 172 2 efficacy efficacy NN cord-301692-zu0ubwfq 172 3 of of IN cord-301692-zu0ubwfq 172 4 a a DT cord-301692-zu0ubwfq 172 5 given give VBN cord-301692-zu0ubwfq 172 6 vaccine vaccine NN cord-301692-zu0ubwfq 172 7 is be VBZ cord-301692-zu0ubwfq 172 8 not not RB cord-301692-zu0ubwfq 172 9 only only RB cord-301692-zu0ubwfq 172 10 related relate VBN cord-301692-zu0ubwfq 172 11 to to IN cord-301692-zu0ubwfq 172 12 its -PRON- PRP$ cord-301692-zu0ubwfq 172 13 immunological immunological JJ cord-301692-zu0ubwfq 172 14 properties property NNS cord-301692-zu0ubwfq 172 15 , , , cord-301692-zu0ubwfq 172 16 but but CC cord-301692-zu0ubwfq 172 17 also also RB cord-301692-zu0ubwfq 172 18 to to IN cord-301692-zu0ubwfq 172 19 the the DT cord-301692-zu0ubwfq 172 20 characteristics characteristic NNS cord-301692-zu0ubwfq 172 21 of of IN cord-301692-zu0ubwfq 172 22 the the DT cord-301692-zu0ubwfq 172 23 challenging challenging JJ cord-301692-zu0ubwfq 172 24 strain strain NN cord-301692-zu0ubwfq 172 25 . . . cord-301692-zu0ubwfq 173 1 Therefore therefore RB cord-301692-zu0ubwfq 173 2 , , , cord-301692-zu0ubwfq 173 3 studies study NNS cord-301692-zu0ubwfq 173 4 on on IN cord-301692-zu0ubwfq 173 5 the the DT cord-301692-zu0ubwfq 173 6 relationship relationship NN cord-301692-zu0ubwfq 173 7 between between IN cord-301692-zu0ubwfq 173 8 genetic genetic JJ cord-301692-zu0ubwfq 173 9 diversity diversity NN cord-301692-zu0ubwfq 173 10 and and CC cord-301692-zu0ubwfq 173 11 the the DT cord-301692-zu0ubwfq 173 12 immunopathological immunopathological JJ cord-301692-zu0ubwfq 173 13 properties property NNS cord-301692-zu0ubwfq 173 14 of of IN cord-301692-zu0ubwfq 173 15 different different JJ cord-301692-zu0ubwfq 173 16 strains strain NNS cord-301692-zu0ubwfq 173 17 are be VBP cord-301692-zu0ubwfq 173 18 needed need VBN cord-301692-zu0ubwfq 173 19 . . . cord-301692-zu0ubwfq 174 1 Reverse reverse JJ cord-301692-zu0ubwfq 174 2 genetics genetic NNS cord-301692-zu0ubwfq 174 3 and and CC cord-301692-zu0ubwfq 174 4 characterisation characterisation NN cord-301692-zu0ubwfq 174 5 of of IN cord-301692-zu0ubwfq 174 6 the the DT cord-301692-zu0ubwfq 174 7 modulating modulate VBG cord-301692-zu0ubwfq 174 8 properties property NNS cord-301692-zu0ubwfq 174 9 of of IN cord-301692-zu0ubwfq 174 10 an an DT cord-301692-zu0ubwfq 174 11 extensive extensive JJ cord-301692-zu0ubwfq 174 12 set set NN cord-301692-zu0ubwfq 174 13 of of IN cord-301692-zu0ubwfq 174 14 strains strain NNS cord-301692-zu0ubwfq 174 15 are be VBP cord-301692-zu0ubwfq 174 16 necessary necessary JJ cord-301692-zu0ubwfq 174 17 ; ; : cord-301692-zu0ubwfq 174 18 this this DT cord-301692-zu0ubwfq 174 19 can can MD cord-301692-zu0ubwfq 174 20 only only RB cord-301692-zu0ubwfq 174 21 be be VB cord-301692-zu0ubwfq 174 22 achieved achieve VBN cord-301692-zu0ubwfq 174 23 through through IN cord-301692-zu0ubwfq 174 24 a a DT cord-301692-zu0ubwfq 174 25 serious serious JJ cord-301692-zu0ubwfq 174 26 international international JJ cord-301692-zu0ubwfq 174 27 collaborative collaborative JJ cord-301692-zu0ubwfq 174 28 effort effort NN cord-301692-zu0ubwfq 174 29 . . . cord-301692-zu0ubwfq 175 1 Thirdly thirdly RB cord-301692-zu0ubwfq 175 2 , , , cord-301692-zu0ubwfq 175 3 the the DT cord-301692-zu0ubwfq 175 4 developed developed JJ cord-301692-zu0ubwfq 175 5 vaccine vaccine NN cord-301692-zu0ubwfq 175 6 should should MD cord-301692-zu0ubwfq 175 7 be be VB cord-301692-zu0ubwfq 175 8 safe safe JJ cord-301692-zu0ubwfq 175 9 . . . cord-301692-zu0ubwfq 176 1 This this DT cord-301692-zu0ubwfq 176 2 means mean VBZ cord-301692-zu0ubwfq 176 3 that that IN cord-301692-zu0ubwfq 176 4 any any DT cord-301692-zu0ubwfq 176 5 possibility possibility NN cord-301692-zu0ubwfq 176 6 of of IN cord-301692-zu0ubwfq 176 7 reversion reversion NN cord-301692-zu0ubwfq 176 8 to to IN cord-301692-zu0ubwfq 176 9 virulence virulence NN cord-301692-zu0ubwfq 176 10 should should MD cord-301692-zu0ubwfq 176 11 be be VB cord-301692-zu0ubwfq 176 12 eliminated eliminate VBN cord-301692-zu0ubwfq 176 13 and and CC cord-301692-zu0ubwfq 176 14 transmission transmission NN cord-301692-zu0ubwfq 176 15 of of IN cord-301692-zu0ubwfq 176 16 the the DT cord-301692-zu0ubwfq 176 17 vaccine vaccine NN cord-301692-zu0ubwfq 176 18 strain strain NN cord-301692-zu0ubwfq 176 19 between between IN cord-301692-zu0ubwfq 176 20 pigs pig NNS cord-301692-zu0ubwfq 176 21 should should MD cord-301692-zu0ubwfq 176 22 be be VB cord-301692-zu0ubwfq 176 23 minimal minimal JJ cord-301692-zu0ubwfq 176 24 or or CC cord-301692-zu0ubwfq 176 25 non non JJ cord-301692-zu0ubwfq 176 26 - - JJ cord-301692-zu0ubwfq 176 27 existent existent JJ cord-301692-zu0ubwfq 176 28 . . . cord-301692-zu0ubwfq 177 1 One one CD cord-301692-zu0ubwfq 177 2 obvious obvious JJ cord-301692-zu0ubwfq 177 3 way way NN cord-301692-zu0ubwfq 177 4 to to TO cord-301692-zu0ubwfq 177 5 gain gain VB cord-301692-zu0ubwfq 177 6 in in IN cord-301692-zu0ubwfq 177 7 safety safety NN cord-301692-zu0ubwfq 177 8 is be VBZ cord-301692-zu0ubwfq 177 9 by by IN cord-301692-zu0ubwfq 177 10 using use VBG cord-301692-zu0ubwfq 177 11 non non JJ cord-301692-zu0ubwfq 177 12 - - JJ cord-301692-zu0ubwfq 177 13 replicating replicate VBG cord-301692-zu0ubwfq 177 14 vaccines vaccine NNS cord-301692-zu0ubwfq 177 15 . . . cord-301692-zu0ubwfq 178 1 However however RB cord-301692-zu0ubwfq 178 2 , , , cord-301692-zu0ubwfq 178 3 it -PRON- PRP cord-301692-zu0ubwfq 178 4 is be VBZ cord-301692-zu0ubwfq 178 5 unclear unclear JJ cord-301692-zu0ubwfq 178 6 if if IN cord-301692-zu0ubwfq 178 7 non non JJ cord-301692-zu0ubwfq 178 8 - - JJ cord-301692-zu0ubwfq 178 9 replicating replicating JJ cord-301692-zu0ubwfq 178 10 vaccines vaccine NNS cord-301692-zu0ubwfq 178 11 are be VBP cord-301692-zu0ubwfq 178 12 able able JJ cord-301692-zu0ubwfq 178 13 to to TO cord-301692-zu0ubwfq 178 14 induce induce VB cord-301692-zu0ubwfq 178 15 NAs na NNS cord-301692-zu0ubwfq 178 16 and and CC cord-301692-zu0ubwfq 178 17 adequate adequate JJ cord-301692-zu0ubwfq 178 18 cell cell NN cord-301692-zu0ubwfq 178 19 - - HYPH cord-301692-zu0ubwfq 178 20 mediated mediate VBN cord-301692-zu0ubwfq 178 21 immune immune JJ cord-301692-zu0ubwfq 178 22 responses response NNS cord-301692-zu0ubwfq 178 23 ( ( -LRB- cord-301692-zu0ubwfq 178 24 Zuckermann Zuckermann NNP cord-301692-zu0ubwfq 178 25 et et NNP cord-301692-zu0ubwfq 178 26 al al NNP cord-301692-zu0ubwfq 178 27 . . NNP cord-301692-zu0ubwfq 178 28 , , , cord-301692-zu0ubwfq 178 29 2007 2007 CD cord-301692-zu0ubwfq 178 30 ) ) -RRB- cord-301692-zu0ubwfq 178 31 . . . cord-301692-zu0ubwfq 179 1 Research research NN cord-301692-zu0ubwfq 179 2 on on IN cord-301692-zu0ubwfq 179 3 subunit subunit NN cord-301692-zu0ubwfq 179 4 or or CC cord-301692-zu0ubwfq 179 5 vector vector NN cord-301692-zu0ubwfq 179 6 - - HYPH cord-301692-zu0ubwfq 179 7 based base VBN cord-301692-zu0ubwfq 179 8 vaccines vaccine NNS cord-301692-zu0ubwfq 179 9 and and CC cord-301692-zu0ubwfq 179 10 adjuvants adjuvant NNS cord-301692-zu0ubwfq 179 11 should should MD cord-301692-zu0ubwfq 179 12 be be VB cord-301692-zu0ubwfq 179 13 undertaken undertake VBN cord-301692-zu0ubwfq 179 14 . . . cord-301692-zu0ubwfq 180 1 Fourthly fourthly RB cord-301692-zu0ubwfq 180 2 , , , cord-301692-zu0ubwfq 180 3 the the DT cord-301692-zu0ubwfq 180 4 development development NN cord-301692-zu0ubwfq 180 5 of of IN cord-301692-zu0ubwfq 180 6 a a DT cord-301692-zu0ubwfq 180 7 differential differential JJ cord-301692-zu0ubwfq 180 8 vaccine vaccine NN cord-301692-zu0ubwfq 180 9 is be VBZ cord-301692-zu0ubwfq 180 10 highly highly RB cord-301692-zu0ubwfq 180 11 desirable desirable JJ cord-301692-zu0ubwfq 180 12 . . . cord-301692-zu0ubwfq 181 1 Since since IN cord-301692-zu0ubwfq 181 2 PRRSV PRRSV NNP cord-301692-zu0ubwfq 181 3 is be VBZ cord-301692-zu0ubwfq 181 4 a a DT cord-301692-zu0ubwfq 181 5 virus virus NN cord-301692-zu0ubwfq 181 6 with with IN cord-301692-zu0ubwfq 181 7 a a DT cord-301692-zu0ubwfq 181 8 relatively relatively RB cord-301692-zu0ubwfq 181 9 small small JJ cord-301692-zu0ubwfq 181 10 genome genome NN cord-301692-zu0ubwfq 181 11 , , , cord-301692-zu0ubwfq 181 12 it -PRON- PRP cord-301692-zu0ubwfq 181 13 is be VBZ cord-301692-zu0ubwfq 181 14 difficult difficult JJ cord-301692-zu0ubwfq 181 15 to to TO cord-301692-zu0ubwfq 181 16 find find VB cord-301692-zu0ubwfq 181 17 targets target NNS cord-301692-zu0ubwfq 181 18 for for IN cord-301692-zu0ubwfq 181 19 deletion deletion NN cord-301692-zu0ubwfq 181 20 , , , cord-301692-zu0ubwfq 181 21 although although IN cord-301692-zu0ubwfq 181 22 , , , cord-301692-zu0ubwfq 181 23 to to IN cord-301692-zu0ubwfq 181 24 our -PRON- PRP$ cord-301692-zu0ubwfq 181 25 knowledge knowledge NN cord-301692-zu0ubwfq 181 26 , , , cord-301692-zu0ubwfq 181 27 an an DT cord-301692-zu0ubwfq 181 28 extensive extensive JJ cord-301692-zu0ubwfq 181 29 study study NN cord-301692-zu0ubwfq 181 30 of of IN cord-301692-zu0ubwfq 181 31 essential essential JJ cord-301692-zu0ubwfq 181 32 and and CC cord-301692-zu0ubwfq 181 33 non non JJ cord-301692-zu0ubwfq 181 34 - - JJ cord-301692-zu0ubwfq 181 35 essential essential JJ cord-301692-zu0ubwfq 181 36 parts part NNS cord-301692-zu0ubwfq 181 37 of of IN cord-301692-zu0ubwfq 181 38 the the DT cord-301692-zu0ubwfq 181 39 viral viral JJ cord-301692-zu0ubwfq 181 40 genome genome NN cord-301692-zu0ubwfq 181 41 has have VBZ cord-301692-zu0ubwfq 181 42 not not RB cord-301692-zu0ubwfq 181 43 been be VBN cord-301692-zu0ubwfq 181 44 performed perform VBN cord-301692-zu0ubwfq 181 45 . . . cord-301692-zu0ubwfq 182 1 The the DT cord-301692-zu0ubwfq 182 2 occurrence occurrence NN cord-301692-zu0ubwfq 182 3 of of IN cord-301692-zu0ubwfq 182 4 natural natural JJ cord-301692-zu0ubwfq 182 5 variants variant NNS cord-301692-zu0ubwfq 182 6 with with IN cord-301692-zu0ubwfq 182 7 small small JJ cord-301692-zu0ubwfq 182 8 deletions deletion NNS cord-301692-zu0ubwfq 182 9 in in IN cord-301692-zu0ubwfq 182 10 nsp2 nsp2 NNP cord-301692-zu0ubwfq 182 11 indicates indicate VBZ cord-301692-zu0ubwfq 182 12 that that IN cord-301692-zu0ubwfq 182 13 non non JJ cord-301692-zu0ubwfq 182 14 - - JJ cord-301692-zu0ubwfq 182 15 structural structural JJ cord-301692-zu0ubwfq 182 16 proteins protein NNS cord-301692-zu0ubwfq 182 17 could could MD cord-301692-zu0ubwfq 182 18 be be VB cord-301692-zu0ubwfq 182 19 a a DT cord-301692-zu0ubwfq 182 20 target target NN cord-301692-zu0ubwfq 182 21 for for IN cord-301692-zu0ubwfq 182 22 constructing construct VBG cord-301692-zu0ubwfq 182 23 differential differential JJ cord-301692-zu0ubwfq 182 24 vaccines vaccine NNS cord-301692-zu0ubwfq 182 25 ( ( -LRB- cord-301692-zu0ubwfq 182 26 Fang Fang NNP cord-301692-zu0ubwfq 182 27 et et FW cord-301692-zu0ubwfq 182 28 al al NNP cord-301692-zu0ubwfq 182 29 . . NNP cord-301692-zu0ubwfq 182 30 , , , cord-301692-zu0ubwfq 182 31 2004 2004 CD cord-301692-zu0ubwfq 182 32 ) ) -RRB- cord-301692-zu0ubwfq 182 33 . . . cord-301692-zu0ubwfq 183 1 It -PRON- PRP cord-301692-zu0ubwfq 183 2 is be VBZ cord-301692-zu0ubwfq 183 3 necessary necessary JJ cord-301692-zu0ubwfq 183 4 to to TO cord-301692-zu0ubwfq 183 5 demonstrate demonstrate VB cord-301692-zu0ubwfq 183 6 that that IN cord-301692-zu0ubwfq 183 7 a a DT cord-301692-zu0ubwfq 183 8 vaccine vaccine NN cord-301692-zu0ubwfq 183 9 protects protect VBZ cord-301692-zu0ubwfq 183 10 against against IN cord-301692-zu0ubwfq 183 11 infection infection NN cord-301692-zu0ubwfq 183 12 , , , cord-301692-zu0ubwfq 183 13 not not RB cord-301692-zu0ubwfq 183 14 only only RB cord-301692-zu0ubwfq 183 15 in in IN cord-301692-zu0ubwfq 183 16 challenge challenge NN cord-301692-zu0ubwfq 183 17 experiments experiment NNS cord-301692-zu0ubwfq 183 18 against against IN cord-301692-zu0ubwfq 183 19 one one CD cord-301692-zu0ubwfq 183 20 strain strain NN cord-301692-zu0ubwfq 183 21 of of IN cord-301692-zu0ubwfq 183 22 the the DT cord-301692-zu0ubwfq 183 23 same same JJ cord-301692-zu0ubwfq 183 24 or or CC cord-301692-zu0ubwfq 183 25 a a DT cord-301692-zu0ubwfq 183 26 different different JJ cord-301692-zu0ubwfq 183 27 genotype genotype NN cord-301692-zu0ubwfq 183 28 , , , cord-301692-zu0ubwfq 183 29 but but CC cord-301692-zu0ubwfq 183 30 also also RB cord-301692-zu0ubwfq 183 31 against against IN cord-301692-zu0ubwfq 183 32 different different JJ cord-301692-zu0ubwfq 183 33 strains strain NNS cord-301692-zu0ubwfq 183 34 within within IN cord-301692-zu0ubwfq 183 35 a a DT cord-301692-zu0ubwfq 183 36 given give VBN cord-301692-zu0ubwfq 183 37 genotype genotype NN cord-301692-zu0ubwfq 183 38 . . . cord-301692-zu0ubwfq 184 1 Table table NN cord-301692-zu0ubwfq 184 2 1 1 CD cord-301692-zu0ubwfq 184 3 summarises summarise VBZ cord-301692-zu0ubwfq 184 4 some some DT cord-301692-zu0ubwfq 184 5 of of IN cord-301692-zu0ubwfq 184 6 the the DT cord-301692-zu0ubwfq 184 7 knowledge knowledge NN cord-301692-zu0ubwfq 184 8 already already RB cord-301692-zu0ubwfq 184 9 known know VBN cord-301692-zu0ubwfq 184 10 or or CC cord-301692-zu0ubwfq 184 11 required require VBN cord-301692-zu0ubwfq 184 12 for for IN cord-301692-zu0ubwfq 184 13 developing develop VBG cord-301692-zu0ubwfq 184 14 newer new JJR cord-301692-zu0ubwfq 184 15 vaccines vaccine NNS cord-301692-zu0ubwfq 184 16 . . . cord-301692-zu0ubwfq 185 1 The the DT cord-301692-zu0ubwfq 185 2 number number NN cord-301692-zu0ubwfq 185 3 of of IN cord-301692-zu0ubwfq 185 4 important important JJ cord-301692-zu0ubwfq 185 5 questions question NNS cord-301692-zu0ubwfq 185 6 that that WDT cord-301692-zu0ubwfq 185 7 remain remain VBP cord-301692-zu0ubwfq 185 8 to to TO cord-301692-zu0ubwfq 185 9 be be VB cord-301692-zu0ubwfq 185 10 solved solve VBN cord-301692-zu0ubwfq 185 11 in in IN cord-301692-zu0ubwfq 185 12 PRRS PRRS NNP cord-301692-zu0ubwfq 185 13 immunology immunology NN cord-301692-zu0ubwfq 185 14 is be VBZ cord-301692-zu0ubwfq 185 15 considerable considerable JJ cord-301692-zu0ubwfq 185 16 . . . cord-301692-zu0ubwfq 186 1 For for IN cord-301692-zu0ubwfq 186 2 example example NN cord-301692-zu0ubwfq 186 3 , , , cord-301692-zu0ubwfq 186 4 the the DT cord-301692-zu0ubwfq 186 5 development development NN cord-301692-zu0ubwfq 186 6 of of IN cord-301692-zu0ubwfq 186 7 the the DT cord-301692-zu0ubwfq 186 8 adaptive adaptive JJ cord-301692-zu0ubwfq 186 9 immune immune JJ cord-301692-zu0ubwfq 186 10 response response NN cord-301692-zu0ubwfq 186 11 after after IN cord-301692-zu0ubwfq 186 12 infection infection NN cord-301692-zu0ubwfq 186 13 with with IN cord-301692-zu0ubwfq 186 14 PRRSV PRRSV NNP cord-301692-zu0ubwfq 186 15 or or CC cord-301692-zu0ubwfq 186 16 vaccination vaccination NN cord-301692-zu0ubwfq 186 17 is be VBZ cord-301692-zu0ubwfq 186 18 anomalous anomalous JJ cord-301692-zu0ubwfq 186 19 . . . cord-301692-zu0ubwfq 187 1 IFNc IFNc NNP cord-301692-zu0ubwfq 187 2 secreting secrete VBG cord-301692-zu0ubwfq 187 3 cells cell NNS cord-301692-zu0ubwfq 187 4 appear appear VBP cord-301692-zu0ubwfq 187 5 late late RB cord-301692-zu0ubwfq 187 6 and and CC cord-301692-zu0ubwfq 187 7 evolve evolve VBP cord-301692-zu0ubwfq 187 8 erratically erratically RB cord-301692-zu0ubwfq 187 9 during during IN cord-301692-zu0ubwfq 187 10 the the DT cord-301692-zu0ubwfq 187 11 first first JJ cord-301692-zu0ubwfq 187 12 weeks week NNS cord-301692-zu0ubwfq 187 13 after after IN cord-301692-zu0ubwfq 187 14 infection infection NN cord-301692-zu0ubwfq 187 15 ; ; : cord-301692-zu0ubwfq 187 16 NA NA NNP cord-301692-zu0ubwfq 187 17 responses response NNS cord-301692-zu0ubwfq 187 18 are be VBP cord-301692-zu0ubwfq 187 19 also also RB cord-301692-zu0ubwfq 187 20 delayed delay VBN cord-301692-zu0ubwfq 187 21 . . . cord-301692-zu0ubwfq 188 1 NAs NAs NNP cord-301692-zu0ubwfq 188 2 may may MD cord-301692-zu0ubwfq 188 3 protect protect VB cord-301692-zu0ubwfq 188 4 against against IN cord-301692-zu0ubwfq 188 5 disease disease NN cord-301692-zu0ubwfq 188 6 if if IN cord-301692-zu0ubwfq 188 7 present present JJ cord-301692-zu0ubwfq 188 8 in in IN cord-301692-zu0ubwfq 188 9 sufficient sufficient JJ cord-301692-zu0ubwfq 188 10 quantities quantity NNS cord-301692-zu0ubwfq 188 11 before before IN cord-301692-zu0ubwfq 188 12 infection infection NN cord-301692-zu0ubwfq 188 13 , , , cord-301692-zu0ubwfq 188 14 but but CC cord-301692-zu0ubwfq 188 15 they -PRON- PRP cord-301692-zu0ubwfq 188 16 do do VBP cord-301692-zu0ubwfq 188 17 not not RB cord-301692-zu0ubwfq 188 18 seem seem VB cord-301692-zu0ubwfq 188 19 to to TO cord-301692-zu0ubwfq 188 20 be be VB cord-301692-zu0ubwfq 188 21 essential essential JJ cord-301692-zu0ubwfq 188 22 for for IN cord-301692-zu0ubwfq 188 23 clearing clear VBG cord-301692-zu0ubwfq 188 24 virus virus NN cord-301692-zu0ubwfq 188 25 in in IN cord-301692-zu0ubwfq 188 26 blood blood NN cord-301692-zu0ubwfq 188 27 during during IN cord-301692-zu0ubwfq 188 28 the the DT cord-301692-zu0ubwfq 188 29 course course NN cord-301692-zu0ubwfq 188 30 of of IN cord-301692-zu0ubwfq 188 31 the the DT cord-301692-zu0ubwfq 188 32 infection infection NN cord-301692-zu0ubwfq 188 33 . . . cord-301692-zu0ubwfq 189 1 PRRSV PRRSV NNP cord-301692-zu0ubwfq 189 2 is be VBZ cord-301692-zu0ubwfq 189 3 able able JJ cord-301692-zu0ubwfq 189 4 to to TO cord-301692-zu0ubwfq 189 5 modulate modulate VB cord-301692-zu0ubwfq 189 6 innate innate JJ cord-301692-zu0ubwfq 189 7 responses response NNS cord-301692-zu0ubwfq 189 8 , , , cord-301692-zu0ubwfq 189 9 probably probably RB cord-301692-zu0ubwfq 189 10 through through IN cord-301692-zu0ubwfq 189 11 the the DT cord-301692-zu0ubwfq 189 12 regulation regulation NN cord-301692-zu0ubwfq 189 13 of of IN cord-301692-zu0ubwfq 189 14 IFN IFN NNP cord-301692-zu0ubwfq 189 15 - - : cord-301692-zu0ubwfq 189 16 a a NNP cord-301692-zu0ubwfq 189 17 and and CC cord-301692-zu0ubwfq 189 18 IL-10 IL-10 NNP cord-301692-zu0ubwfq 189 19 responses response NNS cord-301692-zu0ubwfq 189 20 . . . cord-301692-zu0ubwfq 190 1 Two two CD cord-301692-zu0ubwfq 190 2 different different JJ cord-301692-zu0ubwfq 190 3 PRRSV prrsv NN cord-301692-zu0ubwfq 190 4 genotypes genotype NNS cord-301692-zu0ubwfq 190 5 exist exist VBP cord-301692-zu0ubwfq 190 6 that that WDT cord-301692-zu0ubwfq 190 7 have have VBP cord-301692-zu0ubwfq 190 8 evolved evolve VBN cord-301692-zu0ubwfq 190 9 in in IN cord-301692-zu0ubwfq 190 10 parallel parallel NN cord-301692-zu0ubwfq 190 11 . . . cord-301692-zu0ubwfq 191 1 Cross cross NN cord-301692-zu0ubwfq 191 2 protection protection NN cord-301692-zu0ubwfq 191 3 afforded afford VBN cord-301692-zu0ubwfq 191 4 by by IN cord-301692-zu0ubwfq 191 5 each each DT cord-301692-zu0ubwfq 191 6 genotype genotype NN cord-301692-zu0ubwfq 191 7 is be VBZ cord-301692-zu0ubwfq 191 8 only only RB cord-301692-zu0ubwfq 191 9 partial partial JJ cord-301692-zu0ubwfq 191 10 and and CC cord-301692-zu0ubwfq 191 11 genetic genetic JJ cord-301692-zu0ubwfq 191 12 diversity diversity NN cord-301692-zu0ubwfq 191 13 within within IN cord-301692-zu0ubwfq 191 14 each each DT cord-301692-zu0ubwfq 191 15 genotype genotype NN cord-301692-zu0ubwfq 191 16 can can MD cord-301692-zu0ubwfq 191 17 be be VB cord-301692-zu0ubwfq 191 18 high high JJ cord-301692-zu0ubwfq 191 19 enough enough RB cord-301692-zu0ubwfq 191 20 to to TO cord-301692-zu0ubwfq 191 21 allow allow VB cord-301692-zu0ubwfq 191 22 a a DT cord-301692-zu0ubwfq 191 23 vaccinated vaccinated JJ cord-301692-zu0ubwfq 191 24 animal animal NN cord-301692-zu0ubwfq 191 25 to to TO cord-301692-zu0ubwfq 191 26 be be VB cord-301692-zu0ubwfq 191 27 re re VBN cord-301692-zu0ubwfq 191 28 - - VBN cord-301692-zu0ubwfq 191 29 infected infect VBN cord-301692-zu0ubwfq 191 30 by by IN cord-301692-zu0ubwfq 191 31 a a DT cord-301692-zu0ubwfq 191 32 different different JJ cord-301692-zu0ubwfq 191 33 strain strain NN cord-301692-zu0ubwfq 191 34 of of IN cord-301692-zu0ubwfq 191 35 the the DT cord-301692-zu0ubwfq 191 36 same same JJ cord-301692-zu0ubwfq 191 37 genotype genotype NN cord-301692-zu0ubwfq 191 38 . . . cord-301692-zu0ubwfq 192 1 These these DT cord-301692-zu0ubwfq 192 2 circumstances circumstance NNS cord-301692-zu0ubwfq 192 3 create create VBP cord-301692-zu0ubwfq 192 4 difficulty difficulty NN cord-301692-zu0ubwfq 192 5 in in IN cord-301692-zu0ubwfq 192 6 understanding understand VBG cord-301692-zu0ubwfq 192 7 how how WRB cord-301692-zu0ubwfq 192 8 the the DT cord-301692-zu0ubwfq 192 9 immune immune JJ cord-301692-zu0ubwfq 192 10 system system NN cord-301692-zu0ubwfq 192 11 and and CC cord-301692-zu0ubwfq 192 12 the the DT cord-301692-zu0ubwfq 192 13 virus virus NN cord-301692-zu0ubwfq 192 14 interact interact VBP cord-301692-zu0ubwfq 192 15 . . . cord-301692-zu0ubwfq 193 1 It -PRON- PRP cord-301692-zu0ubwfq 193 2 is be VBZ cord-301692-zu0ubwfq 193 3 possible possible JJ cord-301692-zu0ubwfq 193 4 that that IN cord-301692-zu0ubwfq 193 5 different different JJ cord-301692-zu0ubwfq 193 6 PRRSV PRRSV NNP cord-301692-zu0ubwfq 193 7 strains strain NNS cord-301692-zu0ubwfq 193 8 are be VBP cord-301692-zu0ubwfq 193 9 able able JJ cord-301692-zu0ubwfq 193 10 to to TO cord-301692-zu0ubwfq 193 11 modulate modulate VB cord-301692-zu0ubwfq 193 12 or or CC cord-301692-zu0ubwfq 193 13 regulate regulate VB cord-301692-zu0ubwfq 193 14 the the DT cord-301692-zu0ubwfq 193 15 immune immune JJ cord-301692-zu0ubwfq 193 16 system system NN cord-301692-zu0ubwfq 193 17 in in IN cord-301692-zu0ubwfq 193 18 different different JJ cord-301692-zu0ubwfq 193 19 ways way NNS cord-301692-zu0ubwfq 193 20 . . . cord-301692-zu0ubwfq 194 1 Therefore therefore RB cord-301692-zu0ubwfq 194 2 , , , cord-301692-zu0ubwfq 194 3 published publish VBN cord-301692-zu0ubwfq 194 4 experiments experiment NNS cord-301692-zu0ubwfq 194 5 should should MD cord-301692-zu0ubwfq 194 6 be be VB cord-301692-zu0ubwfq 194 7 always always RB cord-301692-zu0ubwfq 194 8 interpreted interpret VBN cord-301692-zu0ubwfq 194 9 with with IN cord-301692-zu0ubwfq 194 10 caution caution NN cord-301692-zu0ubwfq 194 11 , , , cord-301692-zu0ubwfq 194 12 particularly particularly RB cord-301692-zu0ubwfq 194 13 when when WRB cord-301692-zu0ubwfq 194 14 trying try VBG cord-301692-zu0ubwfq 194 15 to to TO cord-301692-zu0ubwfq 194 16 extract extract VB cord-301692-zu0ubwfq 194 17 general general JJ cord-301692-zu0ubwfq 194 18 principles principle NNS cord-301692-zu0ubwfq 194 19 from from IN cord-301692-zu0ubwfq 194 20 a a DT cord-301692-zu0ubwfq 194 21 particular particular JJ cord-301692-zu0ubwfq 194 22 experiment experiment NN cord-301692-zu0ubwfq 194 23 . . . cord-301692-zu0ubwfq 195 1 Collaboration collaboration NN cord-301692-zu0ubwfq 195 2 between between IN cord-301692-zu0ubwfq 195 3 researchers researcher NNS cord-301692-zu0ubwfq 195 4 is be VBZ cord-301692-zu0ubwfq 195 5 the the DT cord-301692-zu0ubwfq 195 6 best good JJS cord-301692-zu0ubwfq 195 7 way way NN cord-301692-zu0ubwfq 195 8 to to TO cord-301692-zu0ubwfq 195 9 enhance enhance VB cord-301692-zu0ubwfq 195 10 our -PRON- PRP$ cord-301692-zu0ubwfq 195 11 understanding understanding NN cord-301692-zu0ubwfq 195 12 of of IN cord-301692-zu0ubwfq 195 13 PRRSV PRRSV NNP cord-301692-zu0ubwfq 195 14 immunology immunology NNP cord-301692-zu0ubwfq 195 15 . . . cord-301692-zu0ubwfq 196 1 To to IN cord-301692-zu0ubwfq 196 2 all all PDT cord-301692-zu0ubwfq 196 3 those those DT cord-301692-zu0ubwfq 196 4 that that WDT cord-301692-zu0ubwfq 196 5 have have VBP cord-301692-zu0ubwfq 196 6 contributed contribute VBN cord-301692-zu0ubwfq 196 7 to to IN cord-301692-zu0ubwfq 196 8 the the DT cord-301692-zu0ubwfq 196 9 better well JJR cord-301692-zu0ubwfq 196 10 understanding understanding NN cord-301692-zu0ubwfq 196 11 of of IN cord-301692-zu0ubwfq 196 12 PRRS PRRS NNP cord-301692-zu0ubwfq 196 13 . . . cord-301692-zu0ubwfq 197 1 Structural structural JJ cord-301692-zu0ubwfq 197 2 proteins protein NNS cord-301692-zu0ubwfq 197 3 seem seem VBP cord-301692-zu0ubwfq 197 4 to to TO cord-301692-zu0ubwfq 197 5 be be VB cord-301692-zu0ubwfq 197 6 mainly mainly RB cord-301692-zu0ubwfq 197 7 essential essential JJ cord-301692-zu0ubwfq 198 1 Some some DT cord-301692-zu0ubwfq 198 2 non non JJ cord-301692-zu0ubwfq 198 3 - - JJ cord-301692-zu0ubwfq 198 4 structural structural JJ cord-301692-zu0ubwfq 198 5 proteins protein NNS cord-301692-zu0ubwfq 198 6 might may MD cord-301692-zu0ubwfq 198 7 be be VB cord-301692-zu0ubwfq 198 8 non non JJ cord-301692-zu0ubwfq 198 9 - - JJ cord-301692-zu0ubwfq 198 10 essential essential JJ cord-301692-zu0ubwfq 198 11 Exact exact JJ cord-301692-zu0ubwfq 198 12 map map NN cord-301692-zu0ubwfq 198 13 of of IN cord-301692-zu0ubwfq 198 14 essential essential JJ cord-301692-zu0ubwfq 198 15 and and CC cord-301692-zu0ubwfq 198 16 nonessential nonessential JJ cord-301692-zu0ubwfq 198 17 proteins protein NNS cord-301692-zu0ubwfq 199 1 Some some DT cord-301692-zu0ubwfq 199 2 of of IN cord-301692-zu0ubwfq 199 3 the the DT cord-301692-zu0ubwfq 199 4 non non JJ cord-301692-zu0ubwfq 199 5 - - JJ cord-301692-zu0ubwfq 199 6 structural structural JJ cord-301692-zu0ubwfq 199 7 proteins protein NNS cord-301692-zu0ubwfq 199 8 may may MD cord-301692-zu0ubwfq 199 9 suffer suffer VB cord-301692-zu0ubwfq 199 10 natural natural JJ cord-301692-zu0ubwfq 199 11 deletions deletion NNS cord-301692-zu0ubwfq 199 12 structural structural JJ cord-301692-zu0ubwfq 199 13 proteins protein NNS cord-301692-zu0ubwfq 199 14 of of IN cord-301692-zu0ubwfq 199 15 a a DT cord-301692-zu0ubwfq 199 16 North north JJ cord-301692-zu0ubwfq 199 17 American american JJ cord-301692-zu0ubwfq 199 18 strain strain NN cord-301692-zu0ubwfq 199 19 of of IN cord-301692-zu0ubwfq 199 20 porcine porcine JJ cord-301692-zu0ubwfq 199 21 reproductive reproductive JJ cord-301692-zu0ubwfq 199 22 and and CC cord-301692-zu0ubwfq 199 23 respiratory respiratory JJ cord-301692-zu0ubwfq 199 24 syndrome syndrome NN cord-301692-zu0ubwfq 199 25 virus virus NN cord-301692-zu0ubwfq 199 26 . . . cord-301692-zu0ubwfq 200 1 Virology Virology NNP cord-301692-zu0ubwfq 200 2 30 30 CD cord-301692-zu0ubwfq 200 3 , , , cord-301692-zu0ubwfq 200 4 410 410 CD cord-301692-zu0ubwfq 200 5 - - SYM cord-301692-zu0ubwfq 200 6 421 421 CD cord-301692-zu0ubwfq 200 7 . . . cord-301692-zu0ubwfq 201 1 Delputte Delputte NNP cord-301692-zu0ubwfq 201 2 , , , cord-301692-zu0ubwfq 201 3 P.L. P.L. NNP cord-301692-zu0ubwfq 201 4 , , , cord-301692-zu0ubwfq 201 5 Meerts Meerts NNP cord-301692-zu0ubwfq 201 6 , , , cord-301692-zu0ubwfq 201 7 P. P. NNP cord-301692-zu0ubwfq 201 8 , , , cord-301692-zu0ubwfq 201 9 Costers Costers NNP cord-301692-zu0ubwfq 201 10 , , , cord-301692-zu0ubwfq 201 11 S. S. NNP cord-301692-zu0ubwfq 201 12 , , , cord-301692-zu0ubwfq 201 13 Nauwynck Nauwynck NNP cord-301692-zu0ubwfq 201 14 , , , cord-301692-zu0ubwfq 201 15 H.J. H.J. NNP cord-301692-zu0ubwfq 201 16 , , , cord-301692-zu0ubwfq 201 17 2004 2004 CD cord-301692-zu0ubwfq 201 18 . . . cord-301692-zu0ubwfq 202 1 Effect effect NN cord-301692-zu0ubwfq 202 2 of of IN cord-301692-zu0ubwfq 202 3 virus virus NN cord-301692-zu0ubwfq 202 4 - - HYPH cord-301692-zu0ubwfq 202 5 specific specific JJ cord-301692-zu0ubwfq 202 6 antibodies antibody NNS cord-301692-zu0ubwfq 202 7 on on IN cord-301692-zu0ubwfq 202 8 attachment attachment NN cord-301692-zu0ubwfq 202 9 , , , cord-301692-zu0ubwfq 202 10 internalization internalization NN cord-301692-zu0ubwfq 202 11 and and CC cord-301692-zu0ubwfq 202 12 infection infection NN cord-301692-zu0ubwfq 202 13 of of IN cord-301692-zu0ubwfq 202 14 porcine porcine JJ cord-301692-zu0ubwfq 202 15 reproductive reproductive JJ cord-301692-zu0ubwfq 202 16 and and CC cord-301692-zu0ubwfq 202 17 respiratory respiratory JJ cord-301692-zu0ubwfq 202 18 syndrome syndrome NN cord-301692-zu0ubwfq 202 19 virus virus NN cord-301692-zu0ubwfq 202 20 in in IN cord-301692-zu0ubwfq 202 21 primary primary JJ cord-301692-zu0ubwfq 202 22 macrophages macrophage NNS cord-301692-zu0ubwfq 202 23 . . . cord-301692-zu0ubwfq 203 1 Veterinary Veterinary NNP cord-301692-zu0ubwfq 203 2 Immunology Immunology NNP cord-301692-zu0ubwfq 203 3 and and CC cord-301692-zu0ubwfq 203 4 Immunopathology Immunopathology NNP cord-301692-zu0ubwfq 203 5 102 102 CD cord-301692-zu0ubwfq 203 6 , , , cord-301692-zu0ubwfq 203 7 179 179 CD cord-301692-zu0ubwfq 203 8 - - SYM cord-301692-zu0ubwfq 203 9 188 188 CD cord-301692-zu0ubwfq 203 10 . . . cord-301692-zu0ubwfq 204 1 Diaz Diaz NNP cord-301692-zu0ubwfq 204 2 , , , cord-301692-zu0ubwfq 204 3 I. I. NNP cord-301692-zu0ubwfq 204 4 , , , cord-301692-zu0ubwfq 204 5 Darwich Darwich NNP cord-301692-zu0ubwfq 204 6 , , , cord-301692-zu0ubwfq 204 7 L. L. NNP cord-301692-zu0ubwfq 204 8 , , , cord-301692-zu0ubwfq 204 9 Pappaterra Pappaterra NNP cord-301692-zu0ubwfq 204 10 , , , cord-301692-zu0ubwfq 204 11 G. G. NNP cord-301692-zu0ubwfq 204 12 , , , cord-301692-zu0ubwfq 204 13 Pujols Pujols NNP cord-301692-zu0ubwfq 204 14 , , , cord-301692-zu0ubwfq 204 15 J. J. NNP cord-301692-zu0ubwfq 204 16 , , , cord-301692-zu0ubwfq 204 17 Mateu Mateu NNP cord-301692-zu0ubwfq 204 18 , , , cord-301692-zu0ubwfq 204 19 E. E. NNP cord-301692-zu0ubwfq 204 20 , , , cord-301692-zu0ubwfq 204 21 2005 2005 CD cord-301692-zu0ubwfq 204 22 _SP cord-301692-zu0ubwfq 204 23 in in IN cord-301692-zu0ubwfq 204 24 pigs pig NNS cord-301692-zu0ubwfq 204 25 recovered recover VBN cord-301692-zu0ubwfq 204 26 from from IN cord-301692-zu0ubwfq 204 27 porcine porcine JJ cord-301692-zu0ubwfq 204 28 respiratory respiratory JJ cord-301692-zu0ubwfq 204 29 and and CC cord-301692-zu0ubwfq 204 30 reproductive reproductive JJ cord-301692-zu0ubwfq 204 31 syndrome syndrome NN cord-301692-zu0ubwfq 204 32 infection infection NN cord-301692-zu0ubwfq 204 33 Differential differential JJ cord-301692-zu0ubwfq 204 34 type type NN cord-301692-zu0ubwfq 205 1 I -PRON- PRP cord-301692-zu0ubwfq 205 2 interferon interferon RB cord-301692-zu0ubwfq 205 3 activation activation NN cord-301692-zu0ubwfq 205 4 and and CC cord-301692-zu0ubwfq 205 5 susceptibility susceptibility NN cord-301692-zu0ubwfq 205 6 of of IN cord-301692-zu0ubwfq 205 7 dendritic dendritic JJ cord-301692-zu0ubwfq 205 8 cell cell NN cord-301692-zu0ubwfq 205 9 populations population NNS cord-301692-zu0ubwfq 205 10 to to IN cord-301692-zu0ubwfq 205 11 porcine porcine JJ cord-301692-zu0ubwfq 205 12 arterivirus arterivirus NNP cord-301692-zu0ubwfq 205 13 Genetic genetic JJ cord-301692-zu0ubwfq 205 14 diversity diversity NN cord-301692-zu0ubwfq 205 15 and and CC cord-301692-zu0ubwfq 205 16 phylogenetic phylogenetic NN cord-301692-zu0ubwfq 205 17 analysis analysis NN cord-301692-zu0ubwfq 205 18 of of IN cord-301692-zu0ubwfq 205 19 glycoprotein glycoprotein NN cord-301692-zu0ubwfq 205 20 5 5 CD cord-301692-zu0ubwfq 205 21 of of IN cord-301692-zu0ubwfq 205 22 European european JJ cord-301692-zu0ubwfq 205 23 - - HYPH cord-301692-zu0ubwfq 205 24 type type NN cord-301692-zu0ubwfq 205 25 porcine porcine JJ cord-301692-zu0ubwfq 205 26 reproductive reproductive JJ cord-301692-zu0ubwfq 205 27 and and CC cord-301692-zu0ubwfq 205 28 respiratory respiratory JJ cord-301692-zu0ubwfq 205 29 virus virus NN cord-301692-zu0ubwfq 205 30 strains strain NNS cord-301692-zu0ubwfq 205 31 in in IN cord-301692-zu0ubwfq 205 32 Spain Spain NNP cord-301692-zu0ubwfq 205 33 Evolution Evolution NNP cord-301692-zu0ubwfq 205 34 of of IN cord-301692-zu0ubwfq 205 35 ORF5 ORF5 NNP cord-301692-zu0ubwfq 205 36 of of IN cord-301692-zu0ubwfq 205 37 Spanish spanish JJ cord-301692-zu0ubwfq 205 38 porcine porcine JJ cord-301692-zu0ubwfq 205 39 reproductive reproductive JJ cord-301692-zu0ubwfq 205 40 and and CC cord-301692-zu0ubwfq 205 41 respiratory respiratory JJ cord-301692-zu0ubwfq 205 42 syndrome syndrome NN cord-301692-zu0ubwfq 205 43 virus virus NN cord-301692-zu0ubwfq 205 44 strains strain VBZ cord-301692-zu0ubwfq 205 45 from from IN cord-301692-zu0ubwfq 205 46 Gradual gradual JJ cord-301692-zu0ubwfq 205 47 development development NN cord-301692-zu0ubwfq 205 48 of of IN cord-301692-zu0ubwfq 205 49 the the DT cord-301692-zu0ubwfq 205 50 interferon-(response interferon-(response NNS cord-301692-zu0ubwfq 205 51 of of IN cord-301692-zu0ubwfq 205 52 swine swine NN cord-301692-zu0ubwfq 205 53 to to IN cord-301692-zu0ubwfq 205 54 porcine porcine JJ cord-301692-zu0ubwfq 205 55 reproductive reproductive JJ cord-301692-zu0ubwfq 205 56 and and CC cord-301692-zu0ubwfq 205 57 respiratory respiratory JJ cord-301692-zu0ubwfq 205 58 syndrome syndrome NN cord-301692-zu0ubwfq 205 59 virus virus NN cord-301692-zu0ubwfq 205 60 infection infection NN cord-301692-zu0ubwfq 205 61 or or CC cord-301692-zu0ubwfq 205 62 vaccination vaccination NN cord-301692-zu0ubwfq 205 63 Strain strain NN cord-301692-zu0ubwfq 205 64 specificity specificity NN cord-301692-zu0ubwfq 205 65 of of IN cord-301692-zu0ubwfq 205 66 the the DT cord-301692-zu0ubwfq 205 67 immune immune JJ cord-301692-zu0ubwfq 205 68 response response NN cord-301692-zu0ubwfq 205 69 of of IN cord-301692-zu0ubwfq 205 70 pigs pig NNS cord-301692-zu0ubwfq 205 71 following follow VBG cord-301692-zu0ubwfq 205 72 vaccination vaccination NN cord-301692-zu0ubwfq 205 73 with with IN cord-301692-zu0ubwfq 205 74 various various JJ cord-301692-zu0ubwfq 205 75 strains strain NNS cord-301692-zu0ubwfq 205 76 of of IN cord-301692-zu0ubwfq 205 77 porcine porcine JJ cord-301692-zu0ubwfq 205 78 reproductive reproductive JJ cord-301692-zu0ubwfq 205 79 and and CC cord-301692-zu0ubwfq 205 80 respiratory respiratory JJ cord-301692-zu0ubwfq 205 81 syndrome syndrome NN cord-301692-zu0ubwfq 205 82 virus virus NN cord-301692-zu0ubwfq 205 83 Molecular molecular JJ cord-301692-zu0ubwfq 205 84 characterization characterization NN cord-301692-zu0ubwfq 205 85 of of IN cord-301692-zu0ubwfq 205 86 Lelystad Lelystad NNP cord-301692-zu0ubwfq 205 87 virus virus NN cord-301692-zu0ubwfq 205 88 Serum serum NN cord-301692-zu0ubwfq 205 89 immune immune JJ cord-301692-zu0ubwfq 205 90 responses response NNS cord-301692-zu0ubwfq 205 91 to to IN cord-301692-zu0ubwfq 205 92 the the DT cord-301692-zu0ubwfq 205 93 proteins protein NNS cord-301692-zu0ubwfq 205 94 of of IN cord-301692-zu0ubwfq 205 95 porcine porcine JJ cord-301692-zu0ubwfq 205 96 reproductive reproductive JJ cord-301692-zu0ubwfq 205 97 and and CC cord-301692-zu0ubwfq 205 98 respiratory respiratory JJ cord-301692-zu0ubwfq 205 99 syndrome syndrome NN cord-301692-zu0ubwfq 205 100 ( ( -LRB- cord-301692-zu0ubwfq 205 101 PRRS PRRS NNP cord-301692-zu0ubwfq 205 102 ) ) -RRB- cord-301692-zu0ubwfq 206 1 virus virus NN cord-301692-zu0ubwfq 206 2 Epitope Epitope NNP cord-301692-zu0ubwfq 206 3 mapping mapping NN cord-301692-zu0ubwfq 206 4 porcine porcine JJ cord-301692-zu0ubwfq 206 5 reproductive reproductive JJ cord-301692-zu0ubwfq 206 6 and and CC cord-301692-zu0ubwfq 206 7 respiratory respiratory JJ cord-301692-zu0ubwfq 206 8 syndrome syndrome NN cord-301692-zu0ubwfq 206 9 virus virus NN cord-301692-zu0ubwfq 206 10 by by IN cord-301692-zu0ubwfq 206 11 phage phage NN cord-301692-zu0ubwfq 206 12 display display NN cord-301692-zu0ubwfq 206 13 : : : cord-301692-zu0ubwfq 207 1 the the DT cord-301692-zu0ubwfq 207 2 nsp2 nsp2 NNP cord-301692-zu0ubwfq 207 3 fragment fragment NN cord-301692-zu0ubwfq 207 4 of of IN cord-301692-zu0ubwfq 207 5 the the DT cord-301692-zu0ubwfq 207 6 replicase replicase NNP cord-301692-zu0ubwfq 207 7 polyprotein polyprotein NNP cord-301692-zu0ubwfq 207 8 contains contain VBZ cord-301692-zu0ubwfq 207 9 a a DT cord-301692-zu0ubwfq 207 10 cluster cluster NN cord-301692-zu0ubwfq 207 11 of of IN cord-301692-zu0ubwfq 207 12 B b NN cord-301692-zu0ubwfq 207 13 - - HYPH cord-301692-zu0ubwfq 207 14 cell cell NN cord-301692-zu0ubwfq 207 15 epitopes epitope NNS cord-301692-zu0ubwfq 208 1 Passive passive JJ cord-301692-zu0ubwfq 208 2 transfer transfer NN cord-301692-zu0ubwfq 208 3 of of IN cord-301692-zu0ubwfq 208 4 virusspecific virusspecific NNP cord-301692-zu0ubwfq 208 5 antibodies antibody NNS cord-301692-zu0ubwfq 208 6 confers confer VBZ cord-301692-zu0ubwfq 208 7 protection protection NN cord-301692-zu0ubwfq 208 8 against against IN cord-301692-zu0ubwfq 208 9 reproductive reproductive JJ cord-301692-zu0ubwfq 208 10 failure failure NN cord-301692-zu0ubwfq 208 11 induced induce VBN cord-301692-zu0ubwfq 208 12 by by IN cord-301692-zu0ubwfq 208 13 a a DT cord-301692-zu0ubwfq 208 14 virulent virulent JJ cord-301692-zu0ubwfq 208 15 strain strain NN cord-301692-zu0ubwfq 208 16 of of IN cord-301692-zu0ubwfq 208 17 porcine porcine JJ cord-301692-zu0ubwfq 208 18 reproductive reproductive JJ cord-301692-zu0ubwfq 208 19 and and CC cord-301692-zu0ubwfq 208 20 respiratory respiratory JJ cord-301692-zu0ubwfq 208 21 syndrome syndrome NN cord-301692-zu0ubwfq 208 22 virus virus NN cord-301692-zu0ubwfq 208 23 and and CC cord-301692-zu0ubwfq 208 24 establishes establish VBZ cord-301692-zu0ubwfq 208 25 sterilizing sterilize VBG cord-301692-zu0ubwfq 208 26 immunity immunity NN cord-301692-zu0ubwfq 208 27 Identification identification NN cord-301692-zu0ubwfq 208 28 of of IN cord-301692-zu0ubwfq 208 29 neutralizing neutralize VBG cord-301692-zu0ubwfq 208 30 and and CC cord-301692-zu0ubwfq 208 31 nonneutralizing nonneutralize VBG cord-301692-zu0ubwfq 208 32 epitopes epitope NNS cord-301692-zu0ubwfq 208 33 in in IN cord-301692-zu0ubwfq 208 34 the the DT cord-301692-zu0ubwfq 208 35 porcine porcine JJ cord-301692-zu0ubwfq 208 36 reproductive reproductive JJ cord-301692-zu0ubwfq 208 37 and and CC cord-301692-zu0ubwfq 208 38 respiratory respiratory JJ cord-301692-zu0ubwfq 208 39 syndrome syndrome NN cord-301692-zu0ubwfq 208 40 virus virus NN cord-301692-zu0ubwfq 208 41 GP5 GP5 NNP cord-301692-zu0ubwfq 208 42 ectodomain ectodomain NNP cord-301692-zu0ubwfq 208 43 antibodies antibody NNS cord-301692-zu0ubwfq 208 44 to to IN cord-301692-zu0ubwfq 208 45 the the DT cord-301692-zu0ubwfq 208 46 ORF5 orf5 JJ cord-301692-zu0ubwfq 208 47 product product NN cord-301692-zu0ubwfq 208 48 of of IN cord-301692-zu0ubwfq 208 49 porcine porcine JJ cord-301692-zu0ubwfq 208 50 reproductive reproductive JJ cord-301692-zu0ubwfq 208 51 and and CC cord-301692-zu0ubwfq 208 52 respiratory respiratory JJ cord-301692-zu0ubwfq 208 53 syndrome syndrome NN cord-301692-zu0ubwfq 208 54 virus virus NN cord-301692-zu0ubwfq 208 55 define define VBP cord-301692-zu0ubwfq 208 56 linear linear JJ cord-301692-zu0ubwfq 208 57 neutralizing neutralize VBG cord-301692-zu0ubwfq 208 58 determinants determinant NNS cord-301692-zu0ubwfq 208 59 Immune Immune NNP cord-301692-zu0ubwfq 208 60 response response NN cord-301692-zu0ubwfq 208 61 in in IN cord-301692-zu0ubwfq 208 62 pigs pig NNS cord-301692-zu0ubwfq 208 63 vaccinated vaccinate VBN cord-301692-zu0ubwfq 208 64 with with IN cord-301692-zu0ubwfq 208 65 plasmid plasmid NN cord-301692-zu0ubwfq 208 66 DNA dna NN cord-301692-zu0ubwfq 208 67 encoding encoding NN cord-301692-zu0ubwfq 208 68 ORF5 orf5 NN cord-301692-zu0ubwfq 208 69 of of IN cord-301692-zu0ubwfq 208 70 porcine porcine JJ cord-301692-zu0ubwfq 208 71 reproductive reproductive JJ cord-301692-zu0ubwfq 208 72 and and CC cord-301692-zu0ubwfq 208 73 respiratory respiratory JJ cord-301692-zu0ubwfq 208 74 syndrome syndrome NN cord-301692-zu0ubwfq 208 75 virus virus NN cord-301692-zu0ubwfq 209 1 The the DT cord-301692-zu0ubwfq 209 2 primary primary JJ cord-301692-zu0ubwfq 209 3 GP5 GP5 NNP cord-301692-zu0ubwfq 209 4 neutralization neutralization NN cord-301692-zu0ubwfq 209 5 epitope epitope NN cord-301692-zu0ubwfq 209 6 of of IN cord-301692-zu0ubwfq 209 7 North north JJ cord-301692-zu0ubwfq 209 8 American american JJ cord-301692-zu0ubwfq 209 9 isolates isolate NNS cord-301692-zu0ubwfq 209 10 of of IN cord-301692-zu0ubwfq 209 11 porcine porcine JJ cord-301692-zu0ubwfq 209 12 reproductive reproductive JJ cord-301692-zu0ubwfq 209 13 and and CC cord-301692-zu0ubwfq 209 14 respiratory respiratory JJ cord-301692-zu0ubwfq 209 15 syndrome syndrome NN cord-301692-zu0ubwfq 209 16 virus virus NN cord-301692-zu0ubwfq 210 1 The the DT cord-301692-zu0ubwfq 210 2 primary primary JJ cord-301692-zu0ubwfq 210 3 neutralization neutralization NN cord-301692-zu0ubwfq 210 4 epitope epitope NN cord-301692-zu0ubwfq 210 5 of of IN cord-301692-zu0ubwfq 210 6 porcine porcine JJ cord-301692-zu0ubwfq 210 7 respiratory respiratory JJ cord-301692-zu0ubwfq 210 8 and and CC cord-301692-zu0ubwfq 210 9 reproductive reproductive JJ cord-301692-zu0ubwfq 210 10 syndrome syndrome NN cord-301692-zu0ubwfq 210 11 virus virus NN cord-301692-zu0ubwfq 210 12 strain strain NN cord-301692-zu0ubwfq 210 13 VR-2332 vr-2332 NN cord-301692-zu0ubwfq 210 14 is be VBZ cord-301692-zu0ubwfq 210 15 located locate VBN cord-301692-zu0ubwfq 210 16 in in IN cord-301692-zu0ubwfq 210 17 the the DT cord-301692-zu0ubwfq 210 18 middle middle NN cord-301692-zu0ubwfq 210 19 of of IN cord-301692-zu0ubwfq 210 20 the the DT cord-301692-zu0ubwfq 210 21 GP5 GP5 NNP cord-301692-zu0ubwfq 210 22 ectodomain ectodomain NNP cord-301692-zu0ubwfq 211 1 The the DT cord-301692-zu0ubwfq 211 2 evolution evolution NN cord-301692-zu0ubwfq 211 3 of of IN cord-301692-zu0ubwfq 211 4 porcine porcine JJ cord-301692-zu0ubwfq 211 5 reproductive reproductive JJ cord-301692-zu0ubwfq 211 6 and and CC cord-301692-zu0ubwfq 211 7 respiratory respiratory JJ cord-301692-zu0ubwfq 211 8 syndrome syndrome NN cord-301692-zu0ubwfq 211 9 virus virus NN cord-301692-zu0ubwfq 211 10 : : : cord-301692-zu0ubwfq 211 11 quasispecies quasispecie NNS cord-301692-zu0ubwfq 211 12 and and CC cord-301692-zu0ubwfq 211 13 emergence emergence NN cord-301692-zu0ubwfq 211 14 of of IN cord-301692-zu0ubwfq 211 15 a a DT cord-301692-zu0ubwfq 211 16 virus virus NN cord-301692-zu0ubwfq 211 17 subpopulation subpopulation NN cord-301692-zu0ubwfq 211 18 during during IN cord-301692-zu0ubwfq 211 19 infection infection NN cord-301692-zu0ubwfq 211 20 of of IN cord-301692-zu0ubwfq 211 21 pigs pig NNS cord-301692-zu0ubwfq 211 22 with with IN cord-301692-zu0ubwfq 211 23 VR-2332 vr-2332 NN cord-301692-zu0ubwfq 211 24 Deciphering decipher VBG cord-301692-zu0ubwfq 211 25 the the DT cord-301692-zu0ubwfq 211 26 involvement involvement NN cord-301692-zu0ubwfq 211 27 of of IN cord-301692-zu0ubwfq 211 28 innate innate JJ cord-301692-zu0ubwfq 211 29 immune immune JJ cord-301692-zu0ubwfq 211 30 factors factor NNS cord-301692-zu0ubwfq 211 31 in in IN cord-301692-zu0ubwfq 211 32 the the DT cord-301692-zu0ubwfq 211 33 development development NN cord-301692-zu0ubwfq 211 34 of of IN cord-301692-zu0ubwfq 211 35 the the DT cord-301692-zu0ubwfq 211 36 host host NN cord-301692-zu0ubwfq 211 37 response response NN cord-301692-zu0ubwfq 211 38 to to IN cord-301692-zu0ubwfq 211 39 PRRSV PRRSV NNP cord-301692-zu0ubwfq 211 40 vaccination vaccination NN cord-301692-zu0ubwfq 211 41 Parameters parameter NNS cord-301692-zu0ubwfq 211 42 of of IN cord-301692-zu0ubwfq 211 43 humoral humoral JJ cord-301692-zu0ubwfq 211 44 and and CC cord-301692-zu0ubwfq 211 45 cellular cellular JJ cord-301692-zu0ubwfq 211 46 immunity immunity NN cord-301692-zu0ubwfq 211 47 following follow VBG cord-301692-zu0ubwfq 211 48 vaccination vaccination NN cord-301692-zu0ubwfq 211 49 of of IN cord-301692-zu0ubwfq 211 50 pigs pig NNS cord-301692-zu0ubwfq 211 51 with with IN cord-301692-zu0ubwfq 211 52 a a DT cord-301692-zu0ubwfq 211 53 European european JJ cord-301692-zu0ubwfq 211 54 modified modify VBN cord-301692-zu0ubwfq 211 55 - - HYPH cord-301692-zu0ubwfq 211 56 live live JJ cord-301692-zu0ubwfq 211 57 strain strain NN cord-301692-zu0ubwfq 211 58 of of IN cord-301692-zu0ubwfq 211 59 porcine porcine JJ cord-301692-zu0ubwfq 211 60 reproductive reproductive JJ cord-301692-zu0ubwfq 211 61 and and CC cord-301692-zu0ubwfq 211 62 respiratory respiratory JJ cord-301692-zu0ubwfq 211 63 syndrome syndrome NN cord-301692-zu0ubwfq 211 64 virus virus NN cord-301692-zu0ubwfq 211 65 ( ( -LRB- cord-301692-zu0ubwfq 211 66 PRRSV PRRSV NNP cord-301692-zu0ubwfq 211 67 ) ) -RRB- cord-301692-zu0ubwfq 211 68 Identification identification NN cord-301692-zu0ubwfq 211 69 of of IN cord-301692-zu0ubwfq 211 70 radically radically RB cord-301692-zu0ubwfq 211 71 different different JJ cord-301692-zu0ubwfq 211 72 variants variant NNS cord-301692-zu0ubwfq 211 73 of of IN cord-301692-zu0ubwfq 211 74 porcine porcine JJ cord-301692-zu0ubwfq 211 75 reproductive reproductive JJ cord-301692-zu0ubwfq 211 76 and and CC cord-301692-zu0ubwfq 211 77 respiratory respiratory JJ cord-301692-zu0ubwfq 211 78 syndrome syndrome NN cord-301692-zu0ubwfq 211 79 virus virus NN cord-301692-zu0ubwfq 211 80 in in IN cord-301692-zu0ubwfq 211 81 Eastern Eastern NNP cord-301692-zu0ubwfq 211 82 Europe Europe NNP cord-301692-zu0ubwfq 211 83 : : : cord-301692-zu0ubwfq 211 84 towards towards IN cord-301692-zu0ubwfq 211 85 a a DT cord-301692-zu0ubwfq 211 86 common common JJ cord-301692-zu0ubwfq 211 87 ancestor ancestor NN cord-301692-zu0ubwfq 211 88 for for IN cord-301692-zu0ubwfq 211 89 European european JJ cord-301692-zu0ubwfq 211 90 and and CC cord-301692-zu0ubwfq 211 91 American american JJ cord-301692-zu0ubwfq 211 92 viruses virus NNS cord-301692-zu0ubwfq 211 93 Porcine porcine JJ cord-301692-zu0ubwfq 211 94 reproductive reproductive JJ cord-301692-zu0ubwfq 211 95 and and CC cord-301692-zu0ubwfq 211 96 respiratory respiratory JJ cord-301692-zu0ubwfq 211 97 syndrome syndrome NN cord-301692-zu0ubwfq 211 98 virus virus NN cord-301692-zu0ubwfq 211 99 strains strain NNS cord-301692-zu0ubwfq 211 100 of of IN cord-301692-zu0ubwfq 211 101 exceptional exceptional JJ cord-301692-zu0ubwfq 211 102 diversity diversity NN cord-301692-zu0ubwfq 211 103 in in IN cord-301692-zu0ubwfq 211 104 Eastern Eastern NNP cord-301692-zu0ubwfq 211 105 Europe Europe NNP cord-301692-zu0ubwfq 211 106 support support VBP cord-301692-zu0ubwfq 211 107 the the DT cord-301692-zu0ubwfq 211 108 definition definition NN cord-301692-zu0ubwfq 211 109 of of IN cord-301692-zu0ubwfq 211 110 new new JJ cord-301692-zu0ubwfq 211 111 genetic genetic JJ cord-301692-zu0ubwfq 211 112 subtypes subtype NNS cord-301692-zu0ubwfq 211 113 Upregulation Upregulation NNP cord-301692-zu0ubwfq 211 114 of of IN cord-301692-zu0ubwfq 211 115 interleukin-10 interleukin-10 NNP cord-301692-zu0ubwfq 211 116 gene gene NN cord-301692-zu0ubwfq 211 117 expression expression NN cord-301692-zu0ubwfq 211 118 in in IN cord-301692-zu0ubwfq 211 119 the the DT cord-301692-zu0ubwfq 211 120 leukocytes leukocyte NNS cord-301692-zu0ubwfq 211 121 of of IN cord-301692-zu0ubwfq 211 122 pigs pig NNS cord-301692-zu0ubwfq 211 123 infected infect VBN cord-301692-zu0ubwfq 211 124 with with IN cord-301692-zu0ubwfq 211 125 porcine porcine JJ cord-301692-zu0ubwfq 211 126 reproductive reproductive JJ cord-301692-zu0ubwfq 211 127 and and CC cord-301692-zu0ubwfq 211 128 respiratory respiratory JJ cord-301692-zu0ubwfq 211 129 syndrome syndrome NN cord-301692-zu0ubwfq 211 130 virus virus NN cord-301692-zu0ubwfq 211 131 Upregulation Upregulation NNP cord-301692-zu0ubwfq 211 132 of of IN cord-301692-zu0ubwfq 211 133 IL-10 IL-10 NNP cord-301692-zu0ubwfq 211 134 gene gene NN cord-301692-zu0ubwfq 211 135 expression expression NN cord-301692-zu0ubwfq 211 136 in in IN cord-301692-zu0ubwfq 211 137 porcine porcine JJ cord-301692-zu0ubwfq 211 138 peripheral peripheral JJ cord-301692-zu0ubwfq 211 139 blood blood NN cord-301692-zu0ubwfq 211 140 mononuclear mononuclear NN cord-301692-zu0ubwfq 211 141 cells cell NNS cord-301692-zu0ubwfq 211 142 by by IN cord-301692-zu0ubwfq 211 143 porcine porcine JJ cord-301692-zu0ubwfq 211 144 reproductive reproductive JJ cord-301692-zu0ubwfq 211 145 and and CC cord-301692-zu0ubwfq 211 146 respiratory respiratory JJ cord-301692-zu0ubwfq 211 147 syndrome syndrome NN cord-301692-zu0ubwfq 211 148 virus virus NN cord-301692-zu0ubwfq 211 149 Detection detection NN cord-301692-zu0ubwfq 211 150 of of IN cord-301692-zu0ubwfq 211 151 antibodies antibody NNS cord-301692-zu0ubwfq 211 152 against against IN cord-301692-zu0ubwfq 211 153 porcine porcine JJ cord-301692-zu0ubwfq 211 154 reproductive reproductive JJ cord-301692-zu0ubwfq 211 155 and and CC cord-301692-zu0ubwfq 211 156 respiratory respiratory JJ cord-301692-zu0ubwfq 211 157 syndrome syndrome NN cord-301692-zu0ubwfq 212 1 ( ( -LRB- cord-301692-zu0ubwfq 212 2 PRRS PRRS NNP cord-301692-zu0ubwfq 212 3 ) ) -RRB- cord-301692-zu0ubwfq 212 4 virus virus NN cord-301692-zu0ubwfq 212 5 in in IN cord-301692-zu0ubwfq 212 6 swine swine NNP cord-301692-zu0ubwfq 212 7 sera sera NNP cord-301692-zu0ubwfq 212 8 by by IN cord-301692-zu0ubwfq 212 9 enzyme enzyme NN cord-301692-zu0ubwfq 212 10 - - HYPH cord-301692-zu0ubwfq 212 11 linked link VBN cord-301692-zu0ubwfq 212 12 immunosorbent immunosorbent JJ cord-301692-zu0ubwfq 212 13 assay assay NN cord-301692-zu0ubwfq 212 14 Increased increase VBN cord-301692-zu0ubwfq 212 15 production production NN cord-301692-zu0ubwfq 212 16 of of IN cord-301692-zu0ubwfq 212 17 proinflammatory proinflammatory JJ cord-301692-zu0ubwfq 212 18 cytokines cytokine NNS cord-301692-zu0ubwfq 212 19 following follow VBG cord-301692-zu0ubwfq 212 20 infection infection NN cord-301692-zu0ubwfq 212 21 with with IN cord-301692-zu0ubwfq 212 22 porcine porcine JJ cord-301692-zu0ubwfq 212 23 reproductive reproductive JJ cord-301692-zu0ubwfq 212 24 and and CC cord-301692-zu0ubwfq 212 25 respiratory respiratory JJ cord-301692-zu0ubwfq 212 26 syndrome syndrome NN cord-301692-zu0ubwfq 212 27 virus virus NN cord-301692-zu0ubwfq 212 28 and and CC cord-301692-zu0ubwfq 212 29 Mycoplasma Mycoplasma NNP cord-301692-zu0ubwfq 212 30 hyopneumoniae hyopneumoniae NN cord-301692-zu0ubwfq 212 31 Differential differential JJ cord-301692-zu0ubwfq 212 32 production production NN cord-301692-zu0ubwfq 212 33 of of IN cord-301692-zu0ubwfq 212 34 proinflammatory proinflammatory JJ cord-301692-zu0ubwfq 212 35 cytokines cytokine NNS cord-301692-zu0ubwfq 212 36 in in IN cord-301692-zu0ubwfq 212 37 the the DT cord-301692-zu0ubwfq 212 38 pig pig NN cord-301692-zu0ubwfq 212 39 lung lung NN cord-301692-zu0ubwfq 212 40 during during IN cord-301692-zu0ubwfq 212 41 different different JJ cord-301692-zu0ubwfq 212 42 respiratory respiratory JJ cord-301692-zu0ubwfq 212 43 virus virus NN cord-301692-zu0ubwfq 212 44 infections infection NNS cord-301692-zu0ubwfq 212 45 : : : cord-301692-zu0ubwfq 212 46 correlations correlation NNS cord-301692-zu0ubwfq 212 47 with with IN cord-301692-zu0ubwfq 212 48 pathogenicity pathogenicity NN cord-301692-zu0ubwfq 212 49 Antibody Antibody NNP cord-301692-zu0ubwfq 212 50 production production NN cord-301692-zu0ubwfq 212 51 and and CC cord-301692-zu0ubwfq 212 52 blastogenic blastogenic NNP cord-301692-zu0ubwfq 212 53 response response NN cord-301692-zu0ubwfq 212 54 in in IN cord-301692-zu0ubwfq 212 55 pigs pig NNS cord-301692-zu0ubwfq 212 56 experimentally experimentally RB cord-301692-zu0ubwfq 212 57 infected infect VBN cord-301692-zu0ubwfq 212 58 with with IN cord-301692-zu0ubwfq 212 59 porcine porcine JJ cord-301692-zu0ubwfq 212 60 reproductive reproductive JJ cord-301692-zu0ubwfq 212 61 and and CC cord-301692-zu0ubwfq 212 62 respiratory respiratory JJ cord-301692-zu0ubwfq 212 63 syndrome syndrome NN cord-301692-zu0ubwfq 212 64 virus virus NN cord-301692-zu0ubwfq 212 65 Porcine porcine JJ cord-301692-zu0ubwfq 212 66 reproductive reproductive JJ cord-301692-zu0ubwfq 212 67 and and CC cord-301692-zu0ubwfq 212 68 respiratory respiratory JJ cord-301692-zu0ubwfq 212 69 syndrome syndrome NN cord-301692-zu0ubwfq 212 70 virus virus NN cord-301692-zu0ubwfq 212 71 productively productively RB cord-301692-zu0ubwfq 212 72 infects infect VBZ cord-301692-zu0ubwfq 212 73 monocyte monocyte NNP cord-301692-zu0ubwfq 212 74 - - HYPH cord-301692-zu0ubwfq 212 75 derived derive VBN cord-301692-zu0ubwfq 212 76 dendritic dendritic JJ cord-301692-zu0ubwfq 212 77 cells cell NNS cord-301692-zu0ubwfq 212 78 and and CC cord-301692-zu0ubwfq 212 79 compromises compromise VBZ cord-301692-zu0ubwfq 212 80 their -PRON- PRP$ cord-301692-zu0ubwfq 212 81 antigen antigen NN cord-301692-zu0ubwfq 212 82 - - HYPH cord-301692-zu0ubwfq 212 83 presenting present VBG cord-301692-zu0ubwfq 212 84 ability ability NN cord-301692-zu0ubwfq 212 85 Monoclonal monoclonal JJ cord-301692-zu0ubwfq 212 86 antibodies antibody NNS cord-301692-zu0ubwfq 212 87 to to IN cord-301692-zu0ubwfq 212 88 the the DT cord-301692-zu0ubwfq 212 89 GP5 GP5 NNS cord-301692-zu0ubwfq 212 90 of of IN cord-301692-zu0ubwfq 212 91 porcine porcine JJ cord-301692-zu0ubwfq 212 92 reproductive reproductive JJ cord-301692-zu0ubwfq 212 93 and and CC cord-301692-zu0ubwfq 212 94 respiratory respiratory JJ cord-301692-zu0ubwfq 212 95 syndrome syndrome NN cord-301692-zu0ubwfq 212 96 virus virus NN cord-301692-zu0ubwfq 212 97 are be VBP cord-301692-zu0ubwfq 212 98 more more RBR cord-301692-zu0ubwfq 212 99 effective effective JJ cord-301692-zu0ubwfq 212 100 in in IN cord-301692-zu0ubwfq 212 101 virus virus NN cord-301692-zu0ubwfq 212 102 neutralization neutralization NN cord-301692-zu0ubwfq 212 103 than than IN cord-301692-zu0ubwfq 212 104 monoclonal monoclonal JJ cord-301692-zu0ubwfq 212 105 antibodies antibody NNS cord-301692-zu0ubwfq 212 106 to to IN cord-301692-zu0ubwfq 212 107 the the DT cord-301692-zu0ubwfq 212 108 GP4 GP4 NNP cord-301692-zu0ubwfq 213 1 The the DT cord-301692-zu0ubwfq 213 2 major major JJ cord-301692-zu0ubwfq 213 3 envelope envelope NN cord-301692-zu0ubwfq 213 4 protein protein NN cord-301692-zu0ubwfq 213 5 , , , cord-301692-zu0ubwfq 213 6 GP5 GP5 NNP cord-301692-zu0ubwfq 213 7 , , , cord-301692-zu0ubwfq 213 8 of of IN cord-301692-zu0ubwfq 213 9 a a DT cord-301692-zu0ubwfq 213 10 European european JJ cord-301692-zu0ubwfq 213 11 porcine porcine JJ cord-301692-zu0ubwfq 213 12 reproductive reproductive JJ cord-301692-zu0ubwfq 213 13 and and CC cord-301692-zu0ubwfq 213 14 respiratory respiratory JJ cord-301692-zu0ubwfq 213 15 syndrome syndrome NN cord-301692-zu0ubwfq 213 16 virus virus NN cord-301692-zu0ubwfq 213 17 contains contain VBZ cord-301692-zu0ubwfq 213 18 a a DT cord-301692-zu0ubwfq 213 19 neutralization neutralization NN cord-301692-zu0ubwfq 213 20 epitope epitope NN cord-301692-zu0ubwfq 213 21 in in IN cord-301692-zu0ubwfq 213 22 its -PRON- PRP$ cord-301692-zu0ubwfq 213 23 N n CD cord-301692-zu0ubwfq 213 24 - - HYPH cord-301692-zu0ubwfq 213 25 terminal terminal NN cord-301692-zu0ubwfq 213 26 ectodomain ectodomain NN cord-301692-zu0ubwfq 213 27 Categorization categorization NN cord-301692-zu0ubwfq 213 28 of of IN cord-301692-zu0ubwfq 213 29 North north JJ cord-301692-zu0ubwfq 213 30 American american JJ cord-301692-zu0ubwfq 213 31 porcine porcine JJ cord-301692-zu0ubwfq 213 32 reproductive reproductive JJ cord-301692-zu0ubwfq 213 33 and and CC cord-301692-zu0ubwfq 213 34 respiratory respiratory JJ cord-301692-zu0ubwfq 213 35 syndrome syndrome NN cord-301692-zu0ubwfq 213 36 viruses virus NNS cord-301692-zu0ubwfq 213 37 : : : cord-301692-zu0ubwfq 213 38 epitopic epitopic NNP cord-301692-zu0ubwfq 213 39 profiles profile NNS cord-301692-zu0ubwfq 213 40 of of IN cord-301692-zu0ubwfq 213 41 the the DT cord-301692-zu0ubwfq 213 42 N N NNP cord-301692-zu0ubwfq 213 43 , , , cord-301692-zu0ubwfq 213 44 M M NNP cord-301692-zu0ubwfq 213 45 , , , cord-301692-zu0ubwfq 213 46 GP5 GP5 NNP cord-301692-zu0ubwfq 213 47 and and CC cord-301692-zu0ubwfq 213 48 GP3 GP3 NNP cord-301692-zu0ubwfq 213 49 proteins protein NNS cord-301692-zu0ubwfq 213 50 and and CC cord-301692-zu0ubwfq 213 51 susceptibility susceptibility NN cord-301692-zu0ubwfq 213 52 to to IN cord-301692-zu0ubwfq 213 53 neutralization neutralization NN cord-301692-zu0ubwfq 214 1 An an DT cord-301692-zu0ubwfq 214 2 indirect indirect JJ cord-301692-zu0ubwfq 214 3 fluorescent fluorescent JJ cord-301692-zu0ubwfq 214 4 antibody antibody NN cord-301692-zu0ubwfq 214 5 test test NN cord-301692-zu0ubwfq 214 6 for for IN cord-301692-zu0ubwfq 214 7 the the DT cord-301692-zu0ubwfq 214 8 detection detection NN cord-301692-zu0ubwfq 214 9 of of IN cord-301692-zu0ubwfq 214 10 antibody antibody NN cord-301692-zu0ubwfq 214 11 to to IN cord-301692-zu0ubwfq 214 12 swine swine VB cord-301692-zu0ubwfq 214 13 infertility infertility NN cord-301692-zu0ubwfq 214 14 and and CC cord-301692-zu0ubwfq 214 15 respiratory respiratory JJ cord-301692-zu0ubwfq 214 16 syndrome syndrome NN cord-301692-zu0ubwfq 214 17 virus virus NN cord-301692-zu0ubwfq 214 18 in in IN cord-301692-zu0ubwfq 214 19 swine swine NNP cord-301692-zu0ubwfq 214 20 sera sera NNP cord-301692-zu0ubwfq 215 1 A a DT cord-301692-zu0ubwfq 215 2 modified modify VBN cord-301692-zu0ubwfq 215 3 serum serum NN cord-301692-zu0ubwfq 215 4 neutralization neutralization NN cord-301692-zu0ubwfq 215 5 test test NN cord-301692-zu0ubwfq 215 6 for for IN cord-301692-zu0ubwfq 215 7 the the DT cord-301692-zu0ubwfq 215 8 detection detection NN cord-301692-zu0ubwfq 215 9 of of IN cord-301692-zu0ubwfq 215 10 antibody antibody NN cord-301692-zu0ubwfq 215 11 to to IN cord-301692-zu0ubwfq 215 12 porcine porcine JJ cord-301692-zu0ubwfq 215 13 reproductive reproductive JJ cord-301692-zu0ubwfq 215 14 and and CC cord-301692-zu0ubwfq 215 15 respiratory respiratory JJ cord-301692-zu0ubwfq 215 16 syndrome syndrome NN cord-301692-zu0ubwfq 215 17 virus virus NN cord-301692-zu0ubwfq 215 18 in in IN cord-301692-zu0ubwfq 215 19 swine swine NNP cord-301692-zu0ubwfq 215 20 sera sera NNP cord-301692-zu0ubwfq 215 21 Antibody Antibody NNP cord-301692-zu0ubwfq 215 22 - - HYPH cord-301692-zu0ubwfq 215 23 dependent dependent JJ cord-301692-zu0ubwfq 215 24 enhancement enhancement NN cord-301692-zu0ubwfq 215 25 ( ( -LRB- cord-301692-zu0ubwfq 215 26 ADE ADE NNP cord-301692-zu0ubwfq 215 27 ) ) -RRB- cord-301692-zu0ubwfq 215 28 of of IN cord-301692-zu0ubwfq 215 29 porcine porcine JJ cord-301692-zu0ubwfq 215 30 reproductive reproductive JJ cord-301692-zu0ubwfq 215 31 and and CC cord-301692-zu0ubwfq 215 32 respiratory respiratory JJ cord-301692-zu0ubwfq 215 33 syndrome syndrome NN cord-301692-zu0ubwfq 215 34 virus virus NN cord-301692-zu0ubwfq 215 35 ( ( -LRB- cord-301692-zu0ubwfq 215 36 PRRSV PRRSV NNP cord-301692-zu0ubwfq 215 37 ) ) -RRB- cord-301692-zu0ubwfq 215 38 infection infection NN cord-301692-zu0ubwfq 215 39 in in IN cord-301692-zu0ubwfq 215 40 pigs pig NNS cord-301692-zu0ubwfq 215 41 Field field NN cord-301692-zu0ubwfq 215 42 isolates isolate NNS cord-301692-zu0ubwfq 215 43 of of IN cord-301692-zu0ubwfq 215 44 porcine porcine JJ cord-301692-zu0ubwfq 215 45 reproductive reproductive JJ cord-301692-zu0ubwfq 215 46 and and CC cord-301692-zu0ubwfq 215 47 respiratory respiratory JJ cord-301692-zu0ubwfq 215 48 syndrome syndrome NN cord-301692-zu0ubwfq 215 49 virus virus NN cord-301692-zu0ubwfq 215 50 ( ( -LRB- cord-301692-zu0ubwfq 215 51 PRRSV PRRSV NNP cord-301692-zu0ubwfq 215 52 ) ) -RRB- cord-301692-zu0ubwfq 215 53 vary vary VBP cord-301692-zu0ubwfq 215 54 in in IN cord-301692-zu0ubwfq 215 55 their -PRON- PRP$ cord-301692-zu0ubwfq 215 56 susceptibility susceptibility NN cord-301692-zu0ubwfq 215 57 to to IN cord-301692-zu0ubwfq 215 58 antibody antibody NN cord-301692-zu0ubwfq 215 59 dependent dependent JJ cord-301692-zu0ubwfq 215 60 enhancement enhancement NN cord-301692-zu0ubwfq 215 61 ( ( -LRB- cord-301692-zu0ubwfq 215 62 ADE ADE NNP cord-301692-zu0ubwfq 215 63 ) ) -RRB- cord-301692-zu0ubwfq 215 64 of of IN cord-301692-zu0ubwfq 215 65 infection infection NN cord-301692-zu0ubwfq 215 66 Characterization characterization NN cord-301692-zu0ubwfq 215 67 of of IN cord-301692-zu0ubwfq 215 68 the the DT cord-301692-zu0ubwfq 215 69 humoral humoral JJ cord-301692-zu0ubwfq 215 70 immune immune JJ cord-301692-zu0ubwfq 215 71 response response NN cord-301692-zu0ubwfq 215 72 to to IN cord-301692-zu0ubwfq 215 73 porcine porcine JJ cord-301692-zu0ubwfq 215 74 reproductive reproductive JJ cord-301692-zu0ubwfq 215 75 and and CC cord-301692-zu0ubwfq 215 76 respiratory respiratory JJ cord-301692-zu0ubwfq 215 77 syndrome syndrome NN cord-301692-zu0ubwfq 215 78 ( ( -LRB- cord-301692-zu0ubwfq 215 79 PRRS PRRS NNP cord-301692-zu0ubwfq 215 80 ) ) -RRB- cord-301692-zu0ubwfq 215 81 virus virus NN cord-301692-zu0ubwfq 215 82 infection infection NN cord-301692-zu0ubwfq 215 83 Assessment Assessment NNP cord-301692-zu0ubwfq 215 84 of of IN cord-301692-zu0ubwfq 215 85 the the DT cord-301692-zu0ubwfq 215 86 efficacy efficacy NN cord-301692-zu0ubwfq 215 87 of of IN cord-301692-zu0ubwfq 215 88 commercial commercial JJ cord-301692-zu0ubwfq 215 89 porcine porcine JJ cord-301692-zu0ubwfq 215 90 reproductive reproductive JJ cord-301692-zu0ubwfq 215 91 and and CC cord-301692-zu0ubwfq 215 92 respiratory respiratory JJ cord-301692-zu0ubwfq 215 93 syndrome syndrome NN cord-301692-zu0ubwfq 215 94 virus virus NN cord-301692-zu0ubwfq 215 95 ( ( -LRB- cord-301692-zu0ubwfq 215 96 PRRSV PRRSV NNP cord-301692-zu0ubwfq 215 97 ) ) -RRB- cord-301692-zu0ubwfq 215 98 vaccines vaccine NNS cord-301692-zu0ubwfq 215 99 based base VBN cord-301692-zu0ubwfq 215 100 on on IN cord-301692-zu0ubwfq 215 101 measurement measurement NN cord-301692-zu0ubwfq 215 102 of of IN cord-301692-zu0ubwfq 215 103 serologic serologic NNP cord-301692-zu0ubwfq 215 104 response response NN cord-301692-zu0ubwfq 215 105 , , , cord-301692-zu0ubwfq 215 106 frequency frequency NN cord-301692-zu0ubwfq 215 107 of of IN cord-301692-zu0ubwfq 215 108 c c NN cord-301692-zu0ubwfq 215 109 - - : cord-301692-zu0ubwfq 215 110 IFN IFN NNP cord-301692-zu0ubwfq 215 111 - - HYPH cord-301692-zu0ubwfq 215 112 producing produce VBG cord-301692-zu0ubwfq 215 113 cells cell NNS cord-301692-zu0ubwfq 215 114 and and CC cord-301692-zu0ubwfq 215 115 virological virological JJ cord-301692-zu0ubwfq 215 116 parameters parameter NNS cord-301692-zu0ubwfq 215 117 of of IN cord-301692-zu0ubwfq 215 118 protection protection NN cord-301692-zu0ubwfq 215 119 upon upon IN cord-301692-zu0ubwfq 215 120 challenge challenge NN