id	sid	tid	token	lemma	pos
cord-306948-wkisfz1m	1	1	key	key	JJ
cord-306948-wkisfz1m	1	2	:	:	:
cord-306948-wkisfz1m	1	3	cord-306948-wkisfz1	cord-306948-wkisfz1	NN
cord-306948-wkisfz1m	1	4	m	m	CD
cord-306948-wkisfz1m	1	5	authors	author	NNS
cord-306948-wkisfz1m	1	6	:	:	:
cord-306948-wkisfz1m	1	7	Han	Han	NNP
cord-306948-wkisfz1m	1	8	,	,	,
cord-306948-wkisfz1m	1	9	Mingyuan	Mingyuan	NNP
cord-306948-wkisfz1m	1	10	;	;	:
cord-306948-wkisfz1m	1	11	Yoo	Yoo	NNP
cord-306948-wkisfz1m	1	12	,	,	,
cord-306948-wkisfz1m	1	13	Dongwan	Dongwan	NNP
cord-306948-wkisfz1m	1	14	title	title	NN
cord-306948-wkisfz1m	1	15	:	:	:
cord-306948-wkisfz1m	2	1	Engineering	engineer	VBG
cord-306948-wkisfz1m	2	2	the	the	DT
cord-306948-wkisfz1m	2	3	PRRS	PRRS	NNP
cord-306948-wkisfz1m	2	4	virus	virus	NN
cord-306948-wkisfz1m	2	5	genome	genome	NN
cord-306948-wkisfz1m	2	6	:	:	:
cord-306948-wkisfz1m	3	1	Updates	update	NNS
cord-306948-wkisfz1m	3	2	and	and	CC
cord-306948-wkisfz1m	3	3	perspectives	perspective	NNS
cord-306948-wkisfz1m	3	4	date	date	NN
cord-306948-wkisfz1m	3	5	:	:	:
cord-306948-wkisfz1m	3	6	2014	2014	CD
cord-306948-wkisfz1m	3	7	-	-	SYM
cord-306948-wkisfz1m	3	8	12	12	CD
cord-306948-wkisfz1m	3	9	-	-	HYPH
cord-306948-wkisfz1m	3	10	05	05	CD
cord-306948-wkisfz1m	3	11	journal	journal	NN
cord-306948-wkisfz1m	3	12	:	:	:
cord-306948-wkisfz1m	4	1	Vet	Vet	NNP
cord-306948-wkisfz1m	4	2	Microbiol	Microbiol	NNP
cord-306948-wkisfz1m	4	3	DOI	DOI	NNP
cord-306948-wkisfz1m	4	4	:	:	:
cord-306948-wkisfz1m	4	5	10.1016	10.1016	CD
cord-306948-wkisfz1m	4	6	/	/	SYM
cord-306948-wkisfz1m	4	7	j.vetmic.2014.10.007	j.vetmic.2014.10.007	NNP
cord-306948-wkisfz1m	4	8	sha	sha	NNP
cord-306948-wkisfz1m	4	9	:	:	:
cord-306948-wkisfz1m	4	10	f148b5f765624a782d972dd3a1da01ac7e6c2831	f148b5f765624a782d972dd3a1da01ac7e6c2831	CD
cord-306948-wkisfz1m	4	11	doc_id	doc_id	CD
cord-306948-wkisfz1m	4	12	:	:	:
cord-306948-wkisfz1m	4	13	306948	306948	CD
cord-306948-wkisfz1m	4	14	cord_uid	cord_uid	NN
cord-306948-wkisfz1m	4	15	:	:	:
cord-306948-wkisfz1m	5	1	wkisfz1	wkisfz1	NN
cord-306948-wkisfz1m	5	2	m	m	NNP
cord-306948-wkisfz1m	5	3	Porcine	Porcine	NNP
cord-306948-wkisfz1m	5	4	reproductive	reproductive	JJ
cord-306948-wkisfz1m	5	5	and	and	CC
cord-306948-wkisfz1m	5	6	respiratory	respiratory	JJ
cord-306948-wkisfz1m	5	7	syndrome	syndrome	NN
cord-306948-wkisfz1m	5	8	virus	virus	NN
cord-306948-wkisfz1m	5	9	(	(	-LRB-
cord-306948-wkisfz1m	5	10	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	5	11	)	)	-RRB-
cord-306948-wkisfz1m	5	12	is	be	VBZ
cord-306948-wkisfz1m	5	13	endemic	endemic	JJ
cord-306948-wkisfz1m	5	14	in	in	IN
cord-306948-wkisfz1m	5	15	most	most	JJS
cord-306948-wkisfz1m	5	16	pig	pig	NN
cord-306948-wkisfz1m	5	17	producing	produce	VBG
cord-306948-wkisfz1m	5	18	countries	country	NNS
cord-306948-wkisfz1m	5	19	worldwide	worldwide	RB
cord-306948-wkisfz1m	5	20	and	and	CC
cord-306948-wkisfz1m	5	21	causes	cause	VBZ
cord-306948-wkisfz1m	5	22	enormous	enormous	JJ
cord-306948-wkisfz1m	5	23	economic	economic	JJ
cord-306948-wkisfz1m	5	24	losses	loss	NNS
cord-306948-wkisfz1m	5	25	to	to	IN
cord-306948-wkisfz1m	5	26	the	the	DT
cord-306948-wkisfz1m	5	27	pork	pork	NN
cord-306948-wkisfz1m	5	28	industry	industry	NN
cord-306948-wkisfz1m	5	29	.	.	.
cord-306948-wkisfz1m	6	1	Infectious	infectious	JJ
cord-306948-wkisfz1m	6	2	clones	clone	NNS
cord-306948-wkisfz1m	6	3	for	for	IN
cord-306948-wkisfz1m	6	4	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	6	5	have	have	VBP
cord-306948-wkisfz1m	6	6	been	be	VBN
cord-306948-wkisfz1m	6	7	constructed	construct	VBN
cord-306948-wkisfz1m	6	8	,	,	,
cord-306948-wkisfz1m	6	9	and	and	CC
cord-306948-wkisfz1m	6	10	so	so	RB
cord-306948-wkisfz1m	6	11	far	far	RB
cord-306948-wkisfz1m	6	12	at	at	RB
cord-306948-wkisfz1m	6	13	least	least	JJS
cord-306948-wkisfz1m	6	14	14	14	CD
cord-306948-wkisfz1m	6	15	different	different	JJ
cord-306948-wkisfz1m	6	16	infectious	infectious	JJ
cord-306948-wkisfz1m	6	17	clones	clone	NNS
cord-306948-wkisfz1m	6	18	are	be	VBP
cord-306948-wkisfz1m	6	19	available	available	JJ
cord-306948-wkisfz1m	6	20	representing	represent	VBG
cord-306948-wkisfz1m	6	21	both	both	DT
cord-306948-wkisfz1m	6	22	genotypes	genotype	NNS
cord-306948-wkisfz1m	6	23	I	-PRON-	PRP
cord-306948-wkisfz1m	6	24	and	and	CC
cord-306948-wkisfz1m	6	25	II	II	NNP
cord-306948-wkisfz1m	6	26	.	.	.
cord-306948-wkisfz1m	7	1	Two	two	CD
cord-306948-wkisfz1m	7	2	strategies	strategy	NNS
cord-306948-wkisfz1m	7	3	have	have	VBP
cord-306948-wkisfz1m	7	4	been	be	VBN
cord-306948-wkisfz1m	7	5	taken	take	VBN
cord-306948-wkisfz1m	7	6	for	for	IN
cord-306948-wkisfz1m	7	7	progeny	progeny	JJ
cord-306948-wkisfz1m	7	8	reconstitution	reconstitution	NN
cord-306948-wkisfz1m	7	9	:	:	:
cord-306948-wkisfz1m	7	10	RNA	RNA	NNP
cord-306948-wkisfz1m	7	11	transfection	transfection	NN
cord-306948-wkisfz1m	7	12	and	and	CC
cord-306948-wkisfz1m	7	13	DNA	dna	NN
cord-306948-wkisfz1m	7	14	transfection	transfection	NN
cord-306948-wkisfz1m	7	15	.	.	.
cord-306948-wkisfz1m	8	1	Mutations	mutation	NNS
cord-306948-wkisfz1m	8	2	,	,	,
cord-306948-wkisfz1m	8	3	insertions	insertion	NNS
cord-306948-wkisfz1m	8	4	,	,	,
cord-306948-wkisfz1m	8	5	deletions	deletion	NNS
cord-306948-wkisfz1m	8	6	,	,	,
cord-306948-wkisfz1m	8	7	and	and	CC
cord-306948-wkisfz1m	8	8	replacements	replacement	NNS
cord-306948-wkisfz1m	8	9	of	of	IN
cord-306948-wkisfz1m	8	10	the	the	DT
cord-306948-wkisfz1m	8	11	viral	viral	JJ
cord-306948-wkisfz1m	8	12	genome	genome	NN
cord-306948-wkisfz1m	8	13	have	have	VBP
cord-306948-wkisfz1m	8	14	been	be	VBN
cord-306948-wkisfz1m	8	15	employed	employ	VBN
cord-306948-wkisfz1m	8	16	to	to	TO
cord-306948-wkisfz1m	8	17	study	study	VB
cord-306948-wkisfz1m	8	18	the	the	DT
cord-306948-wkisfz1m	8	19	structure	structure	NN
cord-306948-wkisfz1m	8	20	function	function	NN
cord-306948-wkisfz1m	8	21	relationship	relationship	NN
cord-306948-wkisfz1m	8	22	,	,	,
cord-306948-wkisfz1m	8	23	foreign	foreign	JJ
cord-306948-wkisfz1m	8	24	gene	gene	NN
cord-306948-wkisfz1m	8	25	expression	expression	NN
cord-306948-wkisfz1m	8	26	,	,	,
cord-306948-wkisfz1m	8	27	functional	functional	JJ
cord-306948-wkisfz1m	8	28	complementation	complementation	NN
cord-306948-wkisfz1m	8	29	,	,	,
cord-306948-wkisfz1m	8	30	and	and	CC
cord-306948-wkisfz1m	8	31	virulence	virulence	NN
cord-306948-wkisfz1m	8	32	determinants	determinant	NNS
cord-306948-wkisfz1m	8	33	.	.	.
cord-306948-wkisfz1m	9	1	Essential	essential	JJ
cord-306948-wkisfz1m	9	2	regions	region	NNS
cord-306948-wkisfz1m	9	3	and	and	CC
cord-306948-wkisfz1m	9	4	non	non	JJ
cord-306948-wkisfz1m	9	5	-	-	JJ
cord-306948-wkisfz1m	9	6	essential	essential	JJ
cord-306948-wkisfz1m	9	7	regions	region	NNS
cord-306948-wkisfz1m	9	8	for	for	IN
cord-306948-wkisfz1m	9	9	viral	viral	JJ
cord-306948-wkisfz1m	9	10	replication	replication	NN
cord-306948-wkisfz1m	9	11	have	have	VBP
cord-306948-wkisfz1m	9	12	been	be	VBN
cord-306948-wkisfz1m	9	13	identified	identify	VBN
cord-306948-wkisfz1m	9	14	in	in	IN
cord-306948-wkisfz1m	9	15	both	both	CC
cord-306948-wkisfz1m	9	16	the	the	DT
cord-306948-wkisfz1m	9	17	coding	code	VBG
cord-306948-wkisfz1m	9	18	regions	region	NNS
cord-306948-wkisfz1m	9	19	and	and	CC
cord-306948-wkisfz1m	9	20	non	non	JJ
cord-306948-wkisfz1m	9	21	-	-	JJ
cord-306948-wkisfz1m	9	22	encoding	encoding	JJ
cord-306948-wkisfz1m	9	23	regions	region	NNS
cord-306948-wkisfz1m	9	24	.	.	.
cord-306948-wkisfz1m	10	1	Foreign	foreign	JJ
cord-306948-wkisfz1m	10	2	sequences	sequence	NNS
cord-306948-wkisfz1m	10	3	have	have	VBP
cord-306948-wkisfz1m	10	4	successfully	successfully	RB
cord-306948-wkisfz1m	10	5	been	be	VBN
cord-306948-wkisfz1m	10	6	inserted	insert	VBN
cord-306948-wkisfz1m	10	7	into	into	IN
cord-306948-wkisfz1m	10	8	the	the	DT
cord-306948-wkisfz1m	10	9	nsp2	nsp2	NNP
cord-306948-wkisfz1m	10	10	and	and	CC
cord-306948-wkisfz1m	10	11	N	n	CD
cord-306948-wkisfz1m	10	12	regions	region	NNS
cord-306948-wkisfz1m	10	13	and	and	CC
cord-306948-wkisfz1m	10	14	in	in	IN
cord-306948-wkisfz1m	10	15	the	the	DT
cord-306948-wkisfz1m	10	16	space	space	NN
cord-306948-wkisfz1m	10	17	between	between	IN
cord-306948-wkisfz1m	10	18	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	10	19	and	and	CC
cord-306948-wkisfz1m	10	20	ORF2a	ORF2a	NNP
cord-306948-wkisfz1m	10	21	.	.	.
cord-306948-wkisfz1m	11	1	Chimeras	chimera	NNS
cord-306948-wkisfz1m	11	2	between	between	IN
cord-306948-wkisfz1m	11	3	member	member	NN
cord-306948-wkisfz1m	11	4	viruses	virus	NNS
cord-306948-wkisfz1m	11	5	in	in	IN
cord-306948-wkisfz1m	11	6	the	the	DT
cord-306948-wkisfz1m	11	7	family	family	NN
cord-306948-wkisfz1m	11	8	Arteriviridae	Arteriviridae	NNP
cord-306948-wkisfz1m	11	9	have	have	VBP
cord-306948-wkisfz1m	11	10	also	also	RB
cord-306948-wkisfz1m	11	11	been	be	VBN
cord-306948-wkisfz1m	11	12	constructed	construct	VBN
cord-306948-wkisfz1m	11	13	and	and	CC
cord-306948-wkisfz1m	11	14	utilized	utilize	VBN
cord-306948-wkisfz1m	11	15	to	to	TO
cord-306948-wkisfz1m	11	16	study	study	VB
cord-306948-wkisfz1m	11	17	cell	cell	NN
cord-306948-wkisfz1m	11	18	tropism	tropism	NN
cord-306948-wkisfz1m	11	19	and	and	CC
cord-306948-wkisfz1m	11	20	functional	functional	JJ
cord-306948-wkisfz1m	11	21	complementation	complementation	NN
cord-306948-wkisfz1m	11	22	.	.	.
cord-306948-wkisfz1m	12	1	This	this	DT
cord-306948-wkisfz1m	12	2	review	review	NN
cord-306948-wkisfz1m	12	3	discusses	discuss	VBZ
cord-306948-wkisfz1m	12	4	the	the	DT
cord-306948-wkisfz1m	12	5	advances	advance	NNS
cord-306948-wkisfz1m	12	6	and	and	CC
cord-306948-wkisfz1m	12	7	utilization	utilization	NN
cord-306948-wkisfz1m	12	8	of	of	IN
cord-306948-wkisfz1m	12	9	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	12	10	reverse	reverse	VBP
cord-306948-wkisfz1m	12	11	genetics	genetic	NNS
cord-306948-wkisfz1m	12	12	and	and	CC
cord-306948-wkisfz1m	12	13	its	-PRON-	PRP$
cord-306948-wkisfz1m	12	14	potential	potential	NN
cord-306948-wkisfz1m	12	15	for	for	IN
cord-306948-wkisfz1m	12	16	future	future	JJ
cord-306948-wkisfz1m	12	17	research	research	NN
cord-306948-wkisfz1m	12	18	.	.	.
cord-306948-wkisfz1m	13	1	Porcine	porcine	JJ
cord-306948-wkisfz1m	13	2	reproductive	reproductive	JJ
cord-306948-wkisfz1m	13	3	and	and	CC
cord-306948-wkisfz1m	13	4	respiratory	respiratory	JJ
cord-306948-wkisfz1m	13	5	syndrome	syndrome	NN
cord-306948-wkisfz1m	13	6	(	(	-LRB-
cord-306948-wkisfz1m	13	7	PRRS	PRRS	NNP
cord-306948-wkisfz1m	13	8	)	)	-RRB-
cord-306948-wkisfz1m	13	9	was	be	VBD
cord-306948-wkisfz1m	13	10	first	first	RB
cord-306948-wkisfz1m	13	11	reported	report	VBN
cord-306948-wkisfz1m	13	12	in	in	IN
cord-306948-wkisfz1m	13	13	the	the	DT
cord-306948-wkisfz1m	13	14	United	United	NNP
cord-306948-wkisfz1m	13	15	States	States	NNP
cord-306948-wkisfz1m	13	16	in	in	IN
cord-306948-wkisfz1m	13	17	1987	1987	CD
cord-306948-wkisfz1m	13	18	and	and	CC
cord-306948-wkisfz1m	13	19	subsequently	subsequently	RB
cord-306948-wkisfz1m	13	20	in	in	IN
cord-306948-wkisfz1m	13	21	Europe	Europe	NNP
cord-306948-wkisfz1m	13	22	in	in	IN
cord-306948-wkisfz1m	13	23	1990	1990	CD
cord-306948-wkisfz1m	13	24	and	and	CC
cord-306948-wkisfz1m	13	25	quickly	quickly	RB
cord-306948-wkisfz1m	13	26	became	become	VBD
cord-306948-wkisfz1m	13	27	endemic	endemic	JJ
cord-306948-wkisfz1m	13	28	in	in	IN
cord-306948-wkisfz1m	13	29	most	most	JJS
cord-306948-wkisfz1m	13	30	pig	pig	NN
cord-306948-wkisfz1m	13	31	producing	produce	VBG
cord-306948-wkisfz1m	13	32	countries	country	NNS
cord-306948-wkisfz1m	13	33	worldwide	worldwide	RB
cord-306948-wkisfz1m	14	1	(	(	-LRB-
cord-306948-wkisfz1m	14	2	Benfield	Benfield	NNP
cord-306948-wkisfz1m	14	3	et	et	NNP
cord-306948-wkisfz1m	14	4	al	al	NNP
cord-306948-wkisfz1m	14	5	.	.	.
cord-306948-wkisfz1m	15	1	,	,	,
cord-306948-wkisfz1m	15	2	1992	1992	CD
cord-306948-wkisfz1m	15	3	;	;	:
cord-306948-wkisfz1m	15	4	Chand	Chand	NNP
cord-306948-wkisfz1m	15	5	et	et	NNP
cord-306948-wkisfz1m	15	6	al	al	NNP
cord-306948-wkisfz1m	15	7	.	.	NNP
cord-306948-wkisfz1m	15	8	,	,	,
cord-306948-wkisfz1m	15	9	2012	2012	CD
cord-306948-wkisfz1m	15	10	;	;	:
cord-306948-wkisfz1m	15	11	Murakami	Murakami	NNP
cord-306948-wkisfz1m	15	12	et	et	NNP
cord-306948-wkisfz1m	15	13	al	al	NNP
cord-306948-wkisfz1m	15	14	.	.	NNP
cord-306948-wkisfz1m	15	15	,	,	,
cord-306948-wkisfz1m	15	16	1994	1994	CD
cord-306948-wkisfz1m	15	17	;	;	:
cord-306948-wkisfz1m	15	18	Shimizu	Shimizu	NNP
cord-306948-wkisfz1m	15	19	et	et	NNP
cord-306948-wkisfz1m	15	20	al	al	NNP
cord-306948-wkisfz1m	15	21	.	.	.
cord-306948-wkisfz1m	16	1	,	,	,
cord-306948-wkisfz1m	16	2	1994	1994	CD
cord-306948-wkisfz1m	16	3	;	;	:
cord-306948-wkisfz1m	16	4	Wensvoort	Wensvoort	NNP
cord-306948-wkisfz1m	16	5	et	et	NNP
cord-306948-wkisfz1m	16	6	al	al	NNP
cord-306948-wkisfz1m	16	7	.	.	NNP
cord-306948-wkisfz1m	16	8	,	,	,
cord-306948-wkisfz1m	16	9	1991	1991	CD
cord-306948-wkisfz1m	16	10	)	)	-RRB-
cord-306948-wkisfz1m	16	11	.	.	.
cord-306948-wkisfz1m	17	1	The	the	DT
cord-306948-wkisfz1m	17	2	clinical	clinical	JJ
cord-306948-wkisfz1m	17	3	manifestation	manifestation	NN
cord-306948-wkisfz1m	17	4	of	of	IN
cord-306948-wkisfz1m	17	5	PRRS	PRRS	NNP
cord-306948-wkisfz1m	17	6	is	be	VBZ
cord-306948-wkisfz1m	17	7	complicated	complicate	VBN
cord-306948-wkisfz1m	17	8	but	but	CC
cord-306948-wkisfz1m	17	9	is	be	VBZ
cord-306948-wkisfz1m	17	10	characterized	characterize	VBN
cord-306948-wkisfz1m	17	11	by	by	IN
cord-306948-wkisfz1m	17	12	severe	severe	JJ
cord-306948-wkisfz1m	17	13	reproductive	reproductive	JJ
cord-306948-wkisfz1m	17	14	losses	loss	NNS
cord-306948-wkisfz1m	17	15	including	include	VBG
cord-306948-wkisfz1m	17	16	abortions	abortion	NNS
cord-306948-wkisfz1m	17	17	,	,	,
cord-306948-wkisfz1m	17	18	mummified	mummified	JJ
cord-306948-wkisfz1m	17	19	fetuses	fetus	NNS
cord-306948-wkisfz1m	17	20	,	,	,
cord-306948-wkisfz1m	17	21	weak	weak	JJ
cord-306948-wkisfz1m	17	22	born	bear	VBN
cord-306948-wkisfz1m	17	23	and	and	CC
cord-306948-wkisfz1m	17	24	stillborn	stillborn	JJ
cord-306948-wkisfz1m	17	25	young	young	JJ
cord-306948-wkisfz1m	17	26	,	,	,
cord-306948-wkisfz1m	17	27	post	post	JJ
cord-306948-wkisfz1m	17	28	-	-	JJ
cord-306948-wkisfz1m	17	29	weaning	weaning	JJ
cord-306948-wkisfz1m	17	30	pneumonia	pneumonia	NN
cord-306948-wkisfz1m	17	31	,	,	,
cord-306948-wkisfz1m	17	32	increased	increase	VBN
cord-306948-wkisfz1m	17	33	mortality	mortality	NN
cord-306948-wkisfz1m	17	34	,	,	,
cord-306948-wkisfz1m	17	35	and	and	CC
cord-306948-wkisfz1m	17	36	growth	growth	NN
cord-306948-wkisfz1m	17	37	retardation	retardation	NN
cord-306948-wkisfz1m	17	38	of	of	IN
cord-306948-wkisfz1m	17	39	young	young	JJ
cord-306948-wkisfz1m	17	40	pigs	pig	NNS
cord-306948-wkisfz1m	17	41	.	.	.
cord-306948-wkisfz1m	18	1	The	the	DT
cord-306948-wkisfz1m	18	2	etiological	etiological	JJ
cord-306948-wkisfz1m	18	3	agent	agent	NN
cord-306948-wkisfz1m	18	4	is	be	VBZ
cord-306948-wkisfz1m	18	5	PRRS	PRRS	NNP
cord-306948-wkisfz1m	18	6	virus	virus	NN
cord-306948-wkisfz1m	18	7	(	(	-LRB-
cord-306948-wkisfz1m	18	8	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	18	9	)	)	-RRB-
cord-306948-wkisfz1m	18	10	.	.	.
cord-306948-wkisfz1m	19	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	19	2	belongs	belong	VBZ
cord-306948-wkisfz1m	19	3	to	to	IN
cord-306948-wkisfz1m	19	4	the	the	DT
cord-306948-wkisfz1m	19	5	family	family	NN
cord-306948-wkisfz1m	19	6	Arteriviridae	Arteriviridae	NNP
cord-306948-wkisfz1m	19	7	together	together	RB
cord-306948-wkisfz1m	19	8	with	with	IN
cord-306948-wkisfz1m	19	9	lactate	lactate	NN
cord-306948-wkisfz1m	19	10	dehydrogenase	dehydrogenase	NN
cord-306948-wkisfz1m	19	11	-	-	HYPH
cord-306948-wkisfz1m	19	12	elevating	elevate	VBG
cord-306948-wkisfz1m	19	13	virus	virus	NN
cord-306948-wkisfz1m	19	14	(	(	-LRB-
cord-306948-wkisfz1m	19	15	LDV	LDV	NNP
cord-306948-wkisfz1m	19	16	)	)	-RRB-
cord-306948-wkisfz1m	19	17	of	of	IN
cord-306948-wkisfz1m	19	18	mice	mouse	NNS
cord-306948-wkisfz1m	19	19	,	,	,
cord-306948-wkisfz1m	19	20	equine	equine	JJ
cord-306948-wkisfz1m	19	21	arteritis	arteritis	NN
cord-306948-wkisfz1m	19	22	virus	virus	NN
cord-306948-wkisfz1m	19	23	(	(	-LRB-
cord-306948-wkisfz1m	19	24	EAV	EAV	NNP
cord-306948-wkisfz1m	19	25	)	)	-RRB-
cord-306948-wkisfz1m	19	26	,	,	,
cord-306948-wkisfz1m	19	27	and	and	CC
cord-306948-wkisfz1m	19	28	simian	simian	JJ
cord-306948-wkisfz1m	19	29	hemorrhagic	hemorrhagic	JJ
cord-306948-wkisfz1m	19	30	fever	fever	NN
cord-306948-wkisfz1m	19	31	virus	virus	NN
cord-306948-wkisfz1m	19	32	(	(	-LRB-
cord-306948-wkisfz1m	19	33	SHFV	SHFV	NNP
cord-306948-wkisfz1m	19	34	)	)	-RRB-
cord-306948-wkisfz1m	19	35	.	.	.
cord-306948-wkisfz1m	20	1	By	by	IN
cord-306948-wkisfz1m	20	2	comparative	comparative	JJ
cord-306948-wkisfz1m	20	3	genome	genome	NN
cord-306948-wkisfz1m	20	4	sequence	sequence	NN
cord-306948-wkisfz1m	20	5	analysis	analysis	NN
cord-306948-wkisfz1m	20	6	,	,	,
cord-306948-wkisfz1m	20	7	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	20	8	isolates	isolate	NNS
cord-306948-wkisfz1m	20	9	are	be	VBP
cord-306948-wkisfz1m	20	10	divided	divide	VBN
cord-306948-wkisfz1m	20	11	into	into	IN
cord-306948-wkisfz1m	20	12	two	two	CD
cord-306948-wkisfz1m	20	13	distinct	distinct	JJ
cord-306948-wkisfz1m	20	14	genotypes	genotype	NNS
cord-306948-wkisfz1m	20	15	:	:	:
cord-306948-wkisfz1m	20	16	the	the	DT
cord-306948-wkisfz1m	20	17	European	european	JJ
cord-306948-wkisfz1m	20	18	type	type	NN
cord-306948-wkisfz1m	20	19	(	(	-LRB-
cord-306948-wkisfz1m	20	20	genotype	genotype	NN
cord-306948-wkisfz1m	20	21	I	I	NNP
cord-306948-wkisfz1m	20	22	)	)	-RRB-
cord-306948-wkisfz1m	20	23	and	and	CC
cord-306948-wkisfz1m	20	24	North	north	JJ
cord-306948-wkisfz1m	20	25	American	american	JJ
cord-306948-wkisfz1m	20	26	type	type	NN
cord-306948-wkisfz1m	20	27	(	(	-LRB-
cord-306948-wkisfz1m	20	28	genotype	genotype	NNP
cord-306948-wkisfz1m	20	29	II	II	NNP
cord-306948-wkisfz1m	20	30	)	)	-RRB-
cord-306948-wkisfz1m	20	31	,	,	,
cord-306948-wkisfz1m	20	32	represented	represent	VBN
cord-306948-wkisfz1m	20	33	by	by	IN
cord-306948-wkisfz1m	20	34	Lelystad	Lelystad	NNP
cord-306948-wkisfz1m	20	35	virus	virus	NN
cord-306948-wkisfz1m	20	36	(	(	-LRB-
cord-306948-wkisfz1m	20	37	LV	LV	NNP
cord-306948-wkisfz1m	20	38	)	)	-RRB-
cord-306948-wkisfz1m	20	39	and	and	CC
cord-306948-wkisfz1m	20	40	VR-2332	vr-2332	VB
cord-306948-wkisfz1m	20	41	as	as	IN
cord-306948-wkisfz1m	20	42	the	the	DT
cord-306948-wkisfz1m	20	43	prototype	prototype	NN
cord-306948-wkisfz1m	20	44	virus	virus	NN
cord-306948-wkisfz1m	20	45	for	for	IN
cord-306948-wkisfz1m	20	46	each	each	DT
cord-306948-wkisfz1m	20	47	genotype	genotype	NN
cord-306948-wkisfz1m	20	48	,	,	,
cord-306948-wkisfz1m	20	49	respectively	respectively	RB
cord-306948-wkisfz1m	20	50	(	(	-LRB-
cord-306948-wkisfz1m	20	51	Benfield	Benfield	NNP
cord-306948-wkisfz1m	20	52	et	et	NNP
cord-306948-wkisfz1m	20	53	al	al	NNP
cord-306948-wkisfz1m	20	54	.	.	NNP
cord-306948-wkisfz1m	20	55	,	,	,
cord-306948-wkisfz1m	20	56	1992	1992	CD
cord-306948-wkisfz1m	20	57	;	;	:
cord-306948-wkisfz1m	20	58	Wensvoort	Wensvoort	NNP
cord-306948-wkisfz1m	20	59	et	et	NNP
cord-306948-wkisfz1m	20	60	al	al	NNP
cord-306948-wkisfz1m	20	61	.	.	NNP
cord-306948-wkisfz1m	20	62	,	,	,
cord-306948-wkisfz1m	20	63	1991	1991	CD
cord-306948-wkisfz1m	20	64	)	)	-RRB-
cord-306948-wkisfz1m	20	65	.	.	.
cord-306948-wkisfz1m	21	1	The	the	DT
cord-306948-wkisfz1m	21	2	sequence	sequence	NN
cord-306948-wkisfz1m	21	3	similarities	similarity	NNS
cord-306948-wkisfz1m	21	4	between	between	IN
cord-306948-wkisfz1m	21	5	two	two	CD
cord-306948-wkisfz1m	21	6	genotypes	genotype	NNS
cord-306948-wkisfz1m	21	7	are	be	VBP
cord-306948-wkisfz1m	21	8	approximately	approximately	RB
cord-306948-wkisfz1m	21	9	60	60	CD
cord-306948-wkisfz1m	21	10	%	%	NN
cord-306948-wkisfz1m	21	11	(	(	-LRB-
cord-306948-wkisfz1m	21	12	Allende	Allende	NNP
cord-306948-wkisfz1m	21	13	et	et	NNP
cord-306948-wkisfz1m	21	14	al	al	NNP
cord-306948-wkisfz1m	21	15	.	.	NNP
cord-306948-wkisfz1m	21	16	,	,	,
cord-306948-wkisfz1m	21	17	1999	1999	CD
cord-306948-wkisfz1m	21	18	;	;	:
cord-306948-wkisfz1m	22	1	Nelsen	Nelsen	NNP
cord-306948-wkisfz1m	22	2	et	et	NNP
cord-306948-wkisfz1m	22	3	al	al	NNP
cord-306948-wkisfz1m	22	4	.	.	NNP
cord-306948-wkisfz1m	22	5	,	,	,
cord-306948-wkisfz1m	22	6	1999	1999	CD
cord-306948-wkisfz1m	23	1	;	;	:
cord-306948-wkisfz1m	23	2	Wootton	Wootton	NNP
cord-306948-wkisfz1m	23	3	et	et	NNP
cord-306948-wkisfz1m	23	4	al	al	NNP
cord-306948-wkisfz1m	23	5	.	.	NNP
cord-306948-wkisfz1m	23	6	,	,	,
cord-306948-wkisfz1m	23	7	2000	2000	CD
cord-306948-wkisfz1m	23	8	)	)	-RRB-
cord-306948-wkisfz1m	23	9	.	.	.
cord-306948-wkisfz1m	24	1	Amino	amino	NN
cord-306948-wkisfz1m	24	2	acid	acid	NN
cord-306948-wkisfz1m	24	3	(	(	-LRB-
cord-306948-wkisfz1m	24	4	aa	aa	NNP
cord-306948-wkisfz1m	24	5	)	)	-RRB-
cord-306948-wkisfz1m	24	6	sequence	sequence	NN
cord-306948-wkisfz1m	24	7	alignments	alignment	NNS
cord-306948-wkisfz1m	24	8	indicate	indicate	VBP
cord-306948-wkisfz1m	24	9	that	that	IN
cord-306948-wkisfz1m	24	10	the	the	DT
cord-306948-wkisfz1m	24	11	major	major	JJ
cord-306948-wkisfz1m	24	12	differences	difference	NNS
cord-306948-wkisfz1m	24	13	between	between	IN
cord-306948-wkisfz1m	24	14	two	two	CD
cord-306948-wkisfz1m	24	15	genotypes	genotype	NNS
cord-306948-wkisfz1m	24	16	exist	exist	VBP
cord-306948-wkisfz1m	24	17	in	in	IN
cord-306948-wkisfz1m	24	18	the	the	DT
cord-306948-wkisfz1m	24	19	open	open	JJ
cord-306948-wkisfz1m	24	20	reading	reading	NN
cord-306948-wkisfz1m	24	21	frame	frame	NN
cord-306948-wkisfz1m	24	22	(	(	-LRB-
cord-306948-wkisfz1m	24	23	ORF	ORF	NNP
cord-306948-wkisfz1m	24	24	)	)	-RRB-
cord-306948-wkisfz1m	24	25	1a	1a	CD
cord-306948-wkisfz1m	24	26	region	region	NN
cord-306948-wkisfz1m	24	27	and	and	CC
cord-306948-wkisfz1m	24	28	the	the	DT
cord-306948-wkisfz1m	24	29	structural	structural	JJ
cord-306948-wkisfz1m	24	30	protein	protein	NN
cord-306948-wkisfz1m	24	31	region	region	NN
cord-306948-wkisfz1m	25	1	(	(	-LRB-
cord-306948-wkisfz1m	25	2	Kapur	Kapur	NNP
cord-306948-wkisfz1m	25	3	et	et	FW
cord-306948-wkisfz1m	25	4	al	al	NNP
cord-306948-wkisfz1m	25	5	.	.	.
cord-306948-wkisfz1m	26	1	,	,	,
cord-306948-wkisfz1m	26	2	1996	1996	CD
cord-306948-wkisfz1m	26	3	;	;	:
cord-306948-wkisfz1m	26	4	Murtaugh	Murtaugh	NNP
cord-306948-wkisfz1m	26	5	et	et	FW
cord-306948-wkisfz1m	26	6	al	al	NNP
cord-306948-wkisfz1m	26	7	.	.	NNP
cord-306948-wkisfz1m	26	8	,	,	,
cord-306948-wkisfz1m	26	9	1995	1995	CD
cord-306948-wkisfz1m	26	10	;	;	:
cord-306948-wkisfz1m	26	11	Nelsen	Nelsen	NNP
cord-306948-wkisfz1m	26	12	et	et	NNP
cord-306948-wkisfz1m	26	13	al	al	NNP
cord-306948-wkisfz1m	26	14	.	.	NNP
cord-306948-wkisfz1m	26	15	,	,	,
cord-306948-wkisfz1m	26	16	1999	1999	CD
cord-306948-wkisfz1m	26	17	)	)	-RRB-
cord-306948-wkisfz1m	26	18	.	.	.
cord-306948-wkisfz1m	27	1	Natural	natural	JJ
cord-306948-wkisfz1m	27	2	deletions	deletion	NNS
cord-306948-wkisfz1m	27	3	and	and	CC
cord-306948-wkisfz1m	27	4	insertions	insertion	NNS
cord-306948-wkisfz1m	27	5	are	be	VBP
cord-306948-wkisfz1m	27	6	observed	observe	VBN
cord-306948-wkisfz1m	27	7	in	in	IN
cord-306948-wkisfz1m	27	8	some	some	DT
cord-306948-wkisfz1m	27	9	isolates	isolate	NNS
cord-306948-wkisfz1m	27	10	,	,	,
cord-306948-wkisfz1m	27	11	especially	especially	RB
cord-306948-wkisfz1m	27	12	in	in	IN
cord-306948-wkisfz1m	27	13	the	the	DT
cord-306948-wkisfz1m	27	14	ORF1a	ORF1a	NNP
cord-306948-wkisfz1m	27	15	region	region	NN
cord-306948-wkisfz1m	27	16	(	(	-LRB-
cord-306948-wkisfz1m	27	17	Fang	Fang	NNP
cord-306948-wkisfz1m	27	18	et	et	FW
cord-306948-wkisfz1m	27	19	al	al	NNP
cord-306948-wkisfz1m	27	20	.	.	NNP
cord-306948-wkisfz1m	27	21	,	,	,
cord-306948-wkisfz1m	27	22	2004	2004	CD
cord-306948-wkisfz1m	27	23	;	;	:
cord-306948-wkisfz1m	27	24	Gao	Gao	NNP
cord-306948-wkisfz1m	27	25	et	et	NNP
cord-306948-wkisfz1m	27	26	al	al	NNP
cord-306948-wkisfz1m	27	27	.	.	NNP
cord-306948-wkisfz1m	27	28	,	,	,
cord-306948-wkisfz1m	27	29	2004	2004	CD
cord-306948-wkisfz1m	27	30	;	;	:
cord-306948-wkisfz1m	28	1	Shen	Shen	NNP
cord-306948-wkisfz1m	28	2	et	et	NNP
cord-306948-wkisfz1m	28	3	al	al	NNP
cord-306948-wkisfz1m	28	4	.	.	NNP
cord-306948-wkisfz1m	28	5	,	,	,
cord-306948-wkisfz1m	28	6	2000	2000	CD
cord-306948-wkisfz1m	29	1	;	;	:
cord-306948-wkisfz1m	29	2	Tian	Tian	NNP
cord-306948-wkisfz1m	29	3	et	et	NNP
cord-306948-wkisfz1m	29	4	al	al	NNP
cord-306948-wkisfz1m	29	5	.	.	NNP
cord-306948-wkisfz1m	29	6	,	,	,
cord-306948-wkisfz1m	29	7	2007	2007	CD
cord-306948-wkisfz1m	29	8	)	)	-RRB-
cord-306948-wkisfz1m	29	9	.	.	.
cord-306948-wkisfz1m	30	1	The	the	DT
cord-306948-wkisfz1m	30	2	reverse	reverse	JJ
cord-306948-wkisfz1m	30	3	genetics	genetics	NN
cord-306948-wkisfz1m	30	4	system	system	NN
cord-306948-wkisfz1m	30	5	has	have	VBZ
cord-306948-wkisfz1m	30	6	been	be	VBN
cord-306948-wkisfz1m	30	7	developed	develop	VBN
cord-306948-wkisfz1m	30	8	for	for	IN
cord-306948-wkisfz1m	30	9	many	many	JJ
cord-306948-wkisfz1m	30	10	RNA	RNA	NNP
cord-306948-wkisfz1m	30	11	viruses	virus	NNS
cord-306948-wkisfz1m	30	12	,	,	,
cord-306948-wkisfz1m	30	13	and	and	CC
cord-306948-wkisfz1m	30	14	infectious	infectious	JJ
cord-306948-wkisfz1m	30	15	clones	clone	NNS
cord-306948-wkisfz1m	30	16	have	have	VBP
cord-306948-wkisfz1m	30	17	been	be	VBN
cord-306948-wkisfz1m	30	18	utilized	utilize	VBN
cord-306948-wkisfz1m	30	19	for	for	IN
cord-306948-wkisfz1m	30	20	the	the	DT
cord-306948-wkisfz1m	30	21	study	study	NN
cord-306948-wkisfz1m	30	22	of	of	IN
cord-306948-wkisfz1m	30	23	biology	biology	NN
cord-306948-wkisfz1m	30	24	and	and	CC
cord-306948-wkisfz1m	30	25	the	the	DT
cord-306948-wkisfz1m	30	26	vaccinology	vaccinology	NN
cord-306948-wkisfz1m	30	27	of	of	IN
cord-306948-wkisfz1m	30	28	viruses	virus	NNS
cord-306948-wkisfz1m	30	29	.	.	.
cord-306948-wkisfz1m	31	1	The	the	DT
cord-306948-wkisfz1m	31	2	availability	availability	NN
cord-306948-wkisfz1m	31	3	of	of	IN
cord-306948-wkisfz1m	31	4	such	such	PDT
cord-306948-wkisfz1m	31	5	a	a	DT
cord-306948-wkisfz1m	31	6	powerful	powerful	JJ
cord-306948-wkisfz1m	31	7	molecular	molecular	JJ
cord-306948-wkisfz1m	31	8	tool	tool	NN
cord-306948-wkisfz1m	31	9	has	have	VBZ
cord-306948-wkisfz1m	31	10	revolutionized	revolutionize	VBN
cord-306948-wkisfz1m	31	11	the	the	DT
cord-306948-wkisfz1m	31	12	structure	structure	NN
cord-306948-wkisfz1m	31	13	function	function	NN
cord-306948-wkisfz1m	31	14	studies	study	NNS
cord-306948-wkisfz1m	31	15	for	for	IN
cord-306948-wkisfz1m	31	16	viral	viral	JJ
cord-306948-wkisfz1m	31	17	genome	genome	NN
cord-306948-wkisfz1m	31	18	and	and	CC
cord-306948-wkisfz1m	31	19	proteins	protein	NNS
cord-306948-wkisfz1m	31	20	and	and	CC
cord-306948-wkisfz1m	31	21	has	have	VBZ
cord-306948-wkisfz1m	31	22	facilitated	facilitate	VBN
cord-306948-wkisfz1m	31	23	the	the	DT
cord-306948-wkisfz1m	31	24	studies	study	NNS
cord-306948-wkisfz1m	31	25	for	for	IN
cord-306948-wkisfz1m	31	26	virulence	virulence	NN
cord-306948-wkisfz1m	31	27	,	,	,
cord-306948-wkisfz1m	31	28	pathogenesis	pathogenesis	NN
cord-306948-wkisfz1m	31	29	,	,	,
cord-306948-wkisfz1m	31	30	immune	immune	JJ
cord-306948-wkisfz1m	31	31	responses	response	NNS
cord-306948-wkisfz1m	31	32	,	,	,
cord-306948-wkisfz1m	31	33	and	and	CC
cord-306948-wkisfz1m	31	34	vaccine	vaccine	NN
cord-306948-wkisfz1m	31	35	development	development	NN
cord-306948-wkisfz1m	31	36	.	.	.
cord-306948-wkisfz1m	32	1	The	the	DT
cord-306948-wkisfz1m	32	2	first	first	JJ
cord-306948-wkisfz1m	32	3	full	full	JJ
cord-306948-wkisfz1m	32	4	-	-	HYPH
cord-306948-wkisfz1m	32	5	length	length	NN
cord-306948-wkisfz1m	32	6	genomic	genomic	JJ
cord-306948-wkisfz1m	32	7	cDNA	cdna	NN
cord-306948-wkisfz1m	32	8	clone	clone	NN
cord-306948-wkisfz1m	32	9	was	be	VBD
cord-306948-wkisfz1m	32	10	constructed	construct	VBN
cord-306948-wkisfz1m	32	11	for	for	IN
cord-306948-wkisfz1m	32	12	poliovirus	poliovirus	NN
cord-306948-wkisfz1m	32	13	more	more	JJR
cord-306948-wkisfz1m	32	14	than	than	IN
cord-306948-wkisfz1m	32	15	three	three	CD
cord-306948-wkisfz1m	32	16	decades	decade	NNS
cord-306948-wkisfz1m	32	17	ago	ago	RB
cord-306948-wkisfz1m	32	18	and	and	CC
cord-306948-wkisfz1m	32	19	its	-PRON-	PRP$
cord-306948-wkisfz1m	32	20	infectivity	infectivity	NN
cord-306948-wkisfz1m	32	21	was	be	VBD
cord-306948-wkisfz1m	32	22	demonstrated	demonstrate	VBN
cord-306948-wkisfz1m	32	23	(	(	-LRB-
cord-306948-wkisfz1m	32	24	Racaniello	Racaniello	NNP
cord-306948-wkisfz1m	32	25	and	and	CC
cord-306948-wkisfz1m	32	26	Baltimore	Baltimore	NNP
cord-306948-wkisfz1m	32	27	,	,	,
cord-306948-wkisfz1m	32	28	1981	1981	CD
cord-306948-wkisfz1m	32	29	)	)	-RRB-
cord-306948-wkisfz1m	32	30	.	.	.
cord-306948-wkisfz1m	33	1	Infectious	infectious	JJ
cord-306948-wkisfz1m	33	2	clones	clone	NNS
cord-306948-wkisfz1m	33	3	have	have	VBP
cord-306948-wkisfz1m	33	4	since	since	IN
cord-306948-wkisfz1m	33	5	been	be	VBN
cord-306948-wkisfz1m	33	6	constructed	construct	VBN
cord-306948-wkisfz1m	33	7	for	for	IN
cord-306948-wkisfz1m	33	8	picornaviruses	picornavirus	NNS
cord-306948-wkisfz1m	33	9	,	,	,
cord-306948-wkisfz1m	33	10	caliciviruses	caliciviruse	NNS
cord-306948-wkisfz1m	33	11	,	,	,
cord-306948-wkisfz1m	33	12	flaviviruses	flavivirus	NNS
cord-306948-wkisfz1m	33	13	,	,	,
cord-306948-wkisfz1m	33	14	togaviruses	togaviruses	NNP
cord-306948-wkisfz1m	33	15	,	,	,
cord-306948-wkisfz1m	33	16	influenza	influenza	NN
cord-306948-wkisfz1m	33	17	viruses	virus	NNS
cord-306948-wkisfz1m	33	18	,	,	,
cord-306948-wkisfz1m	33	19	paramyxoviruses	paramyxovirus	NNS
cord-306948-wkisfz1m	33	20	,	,	,
cord-306948-wkisfz1m	33	21	rhabdoviruses	rhabdovirus	NNS
cord-306948-wkisfz1m	33	22	,	,	,
cord-306948-wkisfz1m	33	23	and	and	CC
cord-306948-wkisfz1m	33	24	coronaviruses	coronaviruse	NNS
cord-306948-wkisfz1m	33	25	to	to	TO
cord-306948-wkisfz1m	33	26	name	name	VB
cord-306948-wkisfz1m	33	27	a	a	DT
cord-306948-wkisfz1m	33	28	few	few	JJ
cord-306948-wkisfz1m	33	29	(	(	-LRB-
cord-306948-wkisfz1m	33	30	Almazan	Almazan	NNP
cord-306948-wkisfz1m	33	31	et	et	NNP
cord-306948-wkisfz1m	33	32	al	al	NNP
cord-306948-wkisfz1m	33	33	.	.	NNP
cord-306948-wkisfz1m	33	34	,	,	,
cord-306948-wkisfz1m	33	35	2000	2000	CD
cord-306948-wkisfz1m	33	36	;	;	:
cord-306948-wkisfz1m	33	37	Boyer	Boyer	NNP
cord-306948-wkisfz1m	33	38	and	and	CC
cord-306948-wkisfz1m	33	39	Haenni	Haenni	NNP
cord-306948-wkisfz1m	33	40	,	,	,
cord-306948-wkisfz1m	33	41	1994	1994	CD
cord-306948-wkisfz1m	33	42	;	;	:
cord-306948-wkisfz1m	33	43	Pu	Pu	NNP
cord-306948-wkisfz1m	33	44	et	et	NNP
cord-306948-wkisfz1m	33	45	al	al	NNP
cord-306948-wkisfz1m	33	46	.	.	NNP
cord-306948-wkisfz1m	33	47	,	,	,
cord-306948-wkisfz1m	33	48	2011	2011	CD
cord-306948-wkisfz1m	33	49	;	;	:
cord-306948-wkisfz1m	33	50	Scobey	Scobey	NNP
cord-306948-wkisfz1m	33	51	et	et	NNP
cord-306948-wkisfz1m	33	52	al	al	NNP
cord-306948-wkisfz1m	33	53	.	.	NNP
cord-306948-wkisfz1m	33	54	,	,	,
cord-306948-wkisfz1m	33	55	2013	2013	CD
cord-306948-wkisfz1m	33	56	;	;	:
cord-306948-wkisfz1m	33	57	Sosnovtsev	Sosnovtsev	NNP
cord-306948-wkisfz1m	33	58	and	and	CC
cord-306948-wkisfz1m	33	59	Green	Green	NNP
cord-306948-wkisfz1m	33	60	,	,	,
cord-306948-wkisfz1m	33	61	1995	1995	CD
cord-306948-wkisfz1m	33	62	;	;	:
cord-306948-wkisfz1m	33	63	Yount	Yount	NNP
cord-306948-wkisfz1m	33	64	et	et	NNP
cord-306948-wkisfz1m	33	65	al	al	NNP
cord-306948-wkisfz1m	33	66	.	.	NNP
cord-306948-wkisfz1m	33	67	,	,	,
cord-306948-wkisfz1m	33	68	2003	2003	CD
cord-306948-wkisfz1m	33	69	)	)	-RRB-
cord-306948-wkisfz1m	33	70	.	.	.
cord-306948-wkisfz1m	34	1	For	for	IN
cord-306948-wkisfz1m	34	2	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	34	3	,	,	,
cord-306948-wkisfz1m	34	4	EAV	EAV	NNP
cord-306948-wkisfz1m	34	5	and	and	CC
cord-306948-wkisfz1m	34	6	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	34	7	are	be	VBP
cord-306948-wkisfz1m	34	8	the	the	DT
cord-306948-wkisfz1m	34	9	first	first	JJ
cord-306948-wkisfz1m	34	10	for	for	IN
cord-306948-wkisfz1m	34	11	which	which	WDT
cord-306948-wkisfz1m	34	12	the	the	DT
cord-306948-wkisfz1m	34	13	reverse	reverse	JJ
cord-306948-wkisfz1m	34	14	genetics	genetics	NN
cord-306948-wkisfz1m	34	15	system	system	NN
cord-306948-wkisfz1m	34	16	has	have	VBZ
cord-306948-wkisfz1m	34	17	been	be	VBN
cord-306948-wkisfz1m	34	18	developed	develop	VBN
cord-306948-wkisfz1m	34	19	van	van	NNP
cord-306948-wkisfz1m	34	20	Dinten	Dinten	NNP
cord-306948-wkisfz1m	34	21	et	et	FW
cord-306948-wkisfz1m	34	22	al	al	NNP
cord-306948-wkisfz1m	34	23	.	.	NNP
cord-306948-wkisfz1m	34	24	,	,	,
cord-306948-wkisfz1m	34	25	1997	1997	CD
cord-306948-wkisfz1m	34	26	)	)	-RRB-
cord-306948-wkisfz1m	34	27	.	.	.
cord-306948-wkisfz1m	35	1	This	this	DT
cord-306948-wkisfz1m	35	2	review	review	NN
cord-306948-wkisfz1m	35	3	will	will	MD
cord-306948-wkisfz1m	35	4	summarize	summarize	VB
cord-306948-wkisfz1m	35	5	our	-PRON-	PRP$
cord-306948-wkisfz1m	35	6	current	current	JJ
cord-306948-wkisfz1m	35	7	knowledge	knowledge	NN
cord-306948-wkisfz1m	35	8	on	on	IN
cord-306948-wkisfz1m	35	9	the	the	DT
cord-306948-wkisfz1m	35	10	principles	principle	NNS
cord-306948-wkisfz1m	35	11	of	of	IN
cord-306948-wkisfz1m	35	12	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	35	13	infectious	infectious	JJ
cord-306948-wkisfz1m	35	14	clones	clone	NNS
cord-306948-wkisfz1m	35	15	and	and	CC
cord-306948-wkisfz1m	35	16	the	the	DT
cord-306948-wkisfz1m	35	17	application	application	NN
cord-306948-wkisfz1m	35	18	to	to	IN
cord-306948-wkisfz1m	35	19	the	the	DT
cord-306948-wkisfz1m	35	20	study	study	NN
cord-306948-wkisfz1m	35	21	of	of	IN
cord-306948-wkisfz1m	35	22	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	35	23	.	.	.
cord-306948-wkisfz1m	36	1	The	the	DT
cord-306948-wkisfz1m	36	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	36	3	genome	genome	NN
cord-306948-wkisfz1m	36	4	is	be	VBZ
cord-306948-wkisfz1m	36	5	a	a	DT
cord-306948-wkisfz1m	36	6	single	single	JJ
cord-306948-wkisfz1m	36	7	-	-	HYPH
cord-306948-wkisfz1m	36	8	strand	strand	NN
cord-306948-wkisfz1m	36	9	positive	positive	JJ
cord-306948-wkisfz1m	36	10	-	-	HYPH
cord-306948-wkisfz1m	36	11	sense	sense	NN
cord-306948-wkisfz1m	36	12	RNA	RNA	NNP
cord-306948-wkisfz1m	36	13	of	of	IN
cord-306948-wkisfz1m	36	14	15	15	CD
cord-306948-wkisfz1m	36	15	Kb	Kb	NNP
cord-306948-wkisfz1m	36	16	in	in	IN
cord-306948-wkisfz1m	36	17	length	length	NN
cord-306948-wkisfz1m	36	18	with	with	IN
cord-306948-wkisfz1m	36	19	a	a	DT
cord-306948-wkisfz1m	36	20	5	5	CD
cord-306948-wkisfz1m	36	21	0	0	CD
cord-306948-wkisfz1m	36	22	cap	cap	NN
cord-306948-wkisfz1m	36	23	and	and	CC
cord-306948-wkisfz1m	36	24	3	3	CD
cord-306948-wkisfz1m	36	25	0	0	CD
cord-306948-wkisfz1m	36	26	-polyadenylated	-polyadenylate	VBN
cord-306948-wkisfz1m	36	27	tail	tail	NN
cord-306948-wkisfz1m	36	28	(	(	-LRB-
cord-306948-wkisfz1m	36	29	Fig	Fig	NNP
cord-306948-wkisfz1m	36	30	.	.	.
cord-306948-wkisfz1m	36	31	1A	1a	NN
cord-306948-wkisfz1m	36	32	)	)	-RRB-
cord-306948-wkisfz1m	37	1	(	(	-LRB-
cord-306948-wkisfz1m	37	2	Meulenberg	Meulenberg	NNP
cord-306948-wkisfz1m	37	3	et	et	NNP
cord-306948-wkisfz1m	37	4	al	al	NNP
cord-306948-wkisfz1m	37	5	.	.	NNP
cord-306948-wkisfz1m	37	6	,	,	,
cord-306948-wkisfz1m	37	7	1993	1993	CD
cord-306948-wkisfz1m	37	8	;	;	:
cord-306948-wkisfz1m	37	9	Murtaugh	Murtaugh	NNP
cord-306948-wkisfz1m	37	10	et	et	FW
cord-306948-wkisfz1m	37	11	al	al	NNP
cord-306948-wkisfz1m	37	12	.	.	NNP
cord-306948-wkisfz1m	37	13	,	,	,
cord-306948-wkisfz1m	37	14	1995	1995	CD
cord-306948-wkisfz1m	38	1	;	;	:
cord-306948-wkisfz1m	38	2	Nelsen	Nelsen	NNP
cord-306948-wkisfz1m	38	3	et	et	NNP
cord-306948-wkisfz1m	38	4	al	al	NNP
cord-306948-wkisfz1m	38	5	.	.	NNP
cord-306948-wkisfz1m	38	6	,	,	,
cord-306948-wkisfz1m	38	7	1999	1999	CD
cord-306948-wkisfz1m	38	8	;	;	:
cord-306948-wkisfz1m	38	9	Wootton	Wootton	NNP
cord-306948-wkisfz1m	38	10	et	et	NNP
cord-306948-wkisfz1m	38	11	al	al	NNP
cord-306948-wkisfz1m	38	12	.	.	NNP
cord-306948-wkisfz1m	38	13	,	,	,
cord-306948-wkisfz1m	38	14	2000	2000	CD
cord-306948-wkisfz1m	38	15	)	)	-RRB-
cord-306948-wkisfz1m	38	16	.	.	.
cord-306948-wkisfz1m	39	1	The	the	DT
cord-306948-wkisfz1m	39	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	39	3	genome	genome	NN
cord-306948-wkisfz1m	39	4	is	be	VBZ
cord-306948-wkisfz1m	39	5	polycistronic	polycistronic	JJ
cord-306948-wkisfz1m	39	6	and	and	CC
cord-306948-wkisfz1m	39	7	harbors	harbor	VBZ
cord-306948-wkisfz1m	39	8	two	two	CD
cord-306948-wkisfz1m	39	9	large	large	JJ
cord-306948-wkisfz1m	39	10	open	open	JJ
cord-306948-wkisfz1m	39	11	reading	reading	NN
cord-306948-wkisfz1m	39	12	frames	frame	NNS
cord-306948-wkisfz1m	39	13	(	(	-LRB-
cord-306948-wkisfz1m	39	14	ORFs	ORFs	NNP
cord-306948-wkisfz1m	39	15	)	)	-RRB-
cord-306948-wkisfz1m	39	16	,	,	,
cord-306948-wkisfz1m	39	17	ORF1a	ORF1a	NNP
cord-306948-wkisfz1m	39	18	and	and	CC
cord-306948-wkisfz1m	39	19	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	39	20	,	,	,
cord-306948-wkisfz1m	39	21	followed	follow	VBN
cord-306948-wkisfz1m	39	22	by	by	IN
cord-306948-wkisfz1m	39	23	ORF2a	ORF2a	NNP
cord-306948-wkisfz1m	39	24	,	,	,
cord-306948-wkisfz1m	39	25	ORF2b	ORF2b	NNP
cord-306948-wkisfz1m	39	26	,	,	,
cord-306948-wkisfz1m	39	27	and	and	CC
cord-306948-wkisfz1m	39	28	ORFs	ORFs	NNP
cord-306948-wkisfz1m	39	29	3	3	CD
cord-306948-wkisfz1m	39	30	through	through	IN
cord-306948-wkisfz1m	39	31	7	7	CD
cord-306948-wkisfz1m	39	32	,	,	,
cord-306948-wkisfz1m	39	33	plus	plus	CC
cord-306948-wkisfz1m	39	34	ORF5a	ORF5a	NNP
cord-306948-wkisfz1m	39	35	within	within	IN
cord-306948-wkisfz1m	39	36	ORF5	ORF5	NNP
cord-306948-wkisfz1m	40	1	(	(	-LRB-
cord-306948-wkisfz1m	40	2	Firth	Firth	NNP
cord-306948-wkisfz1m	40	3	et	et	NNP
cord-306948-wkisfz1m	40	4	al	al	NNP
cord-306948-wkisfz1m	40	5	.	.	NNP
cord-306948-wkisfz1m	40	6	,	,	,
cord-306948-wkisfz1m	40	7	2011	2011	CD
cord-306948-wkisfz1m	40	8	;	;	:
cord-306948-wkisfz1m	41	1	Johnson	Johnson	NNP
cord-306948-wkisfz1m	41	2	et	et	NNP
cord-306948-wkisfz1m	41	3	al	al	NNP
cord-306948-wkisfz1m	41	4	.	.	NNP
cord-306948-wkisfz1m	41	5	,	,	,
cord-306948-wkisfz1m	41	6	2011	2011	CD
cord-306948-wkisfz1m	42	1	;	;	:
cord-306948-wkisfz1m	42	2	Meulenberg	Meulenberg	NNP
cord-306948-wkisfz1m	42	3	et	et	NNP
cord-306948-wkisfz1m	42	4	al	al	NNP
cord-306948-wkisfz1m	42	5	.	.	NNP
cord-306948-wkisfz1m	42	6	,	,	,
cord-306948-wkisfz1m	42	7	1993	1993	CD
cord-306948-wkisfz1m	42	8	;	;	:
cord-306948-wkisfz1m	42	9	Murtaugh	Murtaugh	NNP
cord-306948-wkisfz1m	42	10	et	et	FW
cord-306948-wkisfz1m	42	11	al	al	NNP
cord-306948-wkisfz1m	42	12	.	.	NNP
cord-306948-wkisfz1m	42	13	,	,	,
cord-306948-wkisfz1m	42	14	1995	1995	CD
cord-306948-wkisfz1m	43	1	;	;	:
cord-306948-wkisfz1m	43	2	Nelsen	Nelsen	NNP
cord-306948-wkisfz1m	43	3	et	et	NNP
cord-306948-wkisfz1m	43	4	al	al	NNP
cord-306948-wkisfz1m	43	5	.	.	NNP
cord-306948-wkisfz1m	43	6	,	,	,
cord-306948-wkisfz1m	43	7	1999	1999	CD
cord-306948-wkisfz1m	43	8	;	;	:
cord-306948-wkisfz1m	43	9	Wootton	Wootton	NNP
cord-306948-wkisfz1m	43	10	et	et	NNP
cord-306948-wkisfz1m	43	11	al	al	NNP
cord-306948-wkisfz1m	43	12	.	.	NNP
cord-306948-wkisfz1m	43	13	,	,	,
cord-306948-wkisfz1m	43	14	2000	2000	CD
cord-306948-wkisfz1m	43	15	)	)	-RRB-
cord-306948-wkisfz1m	43	16	.	.	.
cord-306948-wkisfz1m	44	1	A	a	DT
cord-306948-wkisfz1m	44	2	-2	-2	JJ
cord-306948-wkisfz1m	44	3	ribosomal	ribosomal	JJ
cord-306948-wkisfz1m	44	4	frame	frame	NN
cord-306948-wkisfz1m	44	5	-	-	HYPH
cord-306948-wkisfz1m	44	6	shifting	shifting	NN
cord-306948-wkisfz1m	44	7	has	have	VBZ
cord-306948-wkisfz1m	44	8	recently	recently	RB
cord-306948-wkisfz1m	44	9	been	be	VBN
cord-306948-wkisfz1m	44	10	identified	identify	VBN
cord-306948-wkisfz1m	44	11	for	for	IN
cord-306948-wkisfz1m	44	12	expression	expression	NN
cord-306948-wkisfz1m	44	13	of	of	IN
cord-306948-wkisfz1m	44	14	nsp2TF	nsp2TF	NNS
cord-306948-wkisfz1m	44	15	in	in	IN
cord-306948-wkisfz1m	44	16	the	the	DT
cord-306948-wkisfz1m	44	17	nsp2-coding	nsp2-code	VBG
cord-306948-wkisfz1m	44	18	region	region	NN
cord-306948-wkisfz1m	44	19	.	.	.
cord-306948-wkisfz1m	45	1	The	the	DT
cord-306948-wkisfz1m	45	2	nsp2TF	nsp2TF	NNP
cord-306948-wkisfz1m	45	3	coding	code	VBG
cord-306948-wkisfz1m	45	4	sequence	sequence	NN
cord-306948-wkisfz1m	45	5	is	be	VBZ
cord-306948-wkisfz1m	45	6	conserved	conserve	VBN
cord-306948-wkisfz1m	45	7	in	in	IN
cord-306948-wkisfz1m	45	8	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	45	9	,	,	,
cord-306948-wkisfz1m	45	10	LDV	LDV	NNP
cord-306948-wkisfz1m	45	11	,	,	,
cord-306948-wkisfz1m	45	12	and	and	CC
cord-306948-wkisfz1m	45	13	SHFV	SHFV	NNP
cord-306948-wkisfz1m	45	14	but	but	CC
cord-306948-wkisfz1m	45	15	absent	absent	JJ
cord-306948-wkisfz1m	45	16	in	in	IN
cord-306948-wkisfz1m	45	17	EAV	EAV	NNP
cord-306948-wkisfz1m	45	18	(	(	-LRB-
cord-306948-wkisfz1m	45	19	Fang	Fang	NNP
cord-306948-wkisfz1m	45	20	et	et	FW
cord-306948-wkisfz1m	45	21	al	al	NNP
cord-306948-wkisfz1m	45	22	.	.	NNP
cord-306948-wkisfz1m	45	23	,	,	,
cord-306948-wkisfz1m	45	24	2012	2012	CD
cord-306948-wkisfz1m	45	25	)	)	-RRB-
cord-306948-wkisfz1m	45	26	.	.	.
cord-306948-wkisfz1m	46	1	The	the	DT
cord-306948-wkisfz1m	46	2	coding	code	VBG
cord-306948-wkisfz1m	46	3	sequences	sequence	NNS
cord-306948-wkisfz1m	46	4	in	in	IN
cord-306948-wkisfz1m	46	5	the	the	DT
cord-306948-wkisfz1m	46	6	viral	viral	JJ
cord-306948-wkisfz1m	46	7	genome	genome	NN
cord-306948-wkisfz1m	46	8	are	be	VBP
cord-306948-wkisfz1m	46	9	flanked	flank	VBN
cord-306948-wkisfz1m	46	10	by	by	IN
cord-306948-wkisfz1m	46	11	the	the	DT
cord-306948-wkisfz1m	46	12	5	5	CD
cord-306948-wkisfz1m	46	13	0	0	CD
cord-306948-wkisfz1m	46	14	and	and	CC
cord-306948-wkisfz1m	46	15	3	3	CD
cord-306948-wkisfz1m	46	16	0	0	CD
cord-306948-wkisfz1m	46	17	un	un	NNP
cord-306948-wkisfz1m	46	18	-	-	HYPH
cord-306948-wkisfz1m	46	19	translated	translate	VBN
cord-306948-wkisfz1m	46	20	regions	region	NNS
cord-306948-wkisfz1m	46	21	(	(	-LRB-
cord-306948-wkisfz1m	46	22	UTRs	UTRs	NNP
cord-306948-wkisfz1m	46	23	)	)	-RRB-
cord-306948-wkisfz1m	46	24	involved	involve	VBN
cord-306948-wkisfz1m	46	25	in	in	IN
cord-306948-wkisfz1m	46	26	translation	translation	NN
cord-306948-wkisfz1m	46	27	,	,	,
cord-306948-wkisfz1m	46	28	replication	replication	NN
cord-306948-wkisfz1m	46	29	,	,	,
cord-306948-wkisfz1m	46	30	and	and	CC
cord-306948-wkisfz1m	46	31	transcription	transcription	NN
cord-306948-wkisfz1m	46	32	(	(	-LRB-
cord-306948-wkisfz1m	46	33	see	see	VB
cord-306948-wkisfz1m	46	34	review	review	NN
cord-306948-wkisfz1m	46	35	in	in	IN
cord-306948-wkisfz1m	46	36	Snijder	Snijder	NNP
cord-306948-wkisfz1m	46	37	et	et	NNP
cord-306948-wkisfz1m	46	38	al	al	NNP
cord-306948-wkisfz1m	46	39	.	.	NNP
cord-306948-wkisfz1m	46	40	,	,	,
cord-306948-wkisfz1m	46	41	2013	2013	CD
cord-306948-wkisfz1m	46	42	)	)	-RRB-
cord-306948-wkisfz1m	46	43	.	.	.
cord-306948-wkisfz1m	47	1	ORF1a	ORF1a	NNP
cord-306948-wkisfz1m	47	2	and	and	CC
cord-306948-wkisfz1m	47	3	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	47	4	code	code	NN
cord-306948-wkisfz1m	47	5	for	for	IN
cord-306948-wkisfz1m	47	6	two	two	CD
cord-306948-wkisfz1m	47	7	large	large	JJ
cord-306948-wkisfz1m	47	8	polyproteins	polyprotein	NNS
cord-306948-wkisfz1m	47	9	,	,	,
cord-306948-wkisfz1m	47	10	pp1a	pp1a	NNP
cord-306948-wkisfz1m	47	11	and	and	CC
cord-306948-wkisfz1m	47	12	pp1ab	pp1ab	NNP
cord-306948-wkisfz1m	47	13	,	,	,
cord-306948-wkisfz1m	47	14	with	with	IN
cord-306948-wkisfz1m	47	15	the	the	DT
cord-306948-wkisfz1m	47	16	expression	expression	NN
cord-306948-wkisfz1m	47	17	of	of	IN
cord-306948-wkisfz1m	47	18	the	the	DT
cord-306948-wkisfz1m	47	19	latter	latter	JJ
cord-306948-wkisfz1m	47	20	mediated	mediate	VBN
cord-306948-wkisfz1m	47	21	by	by	IN
cord-306948-wkisfz1m	47	22	the	the	DT
cord-306948-wkisfz1m	47	23	-1	-1	JJ
cord-306948-wkisfz1m	47	24	frame	frame	NN
cord-306948-wkisfz1m	47	25	-	-	HYPH
cord-306948-wkisfz1m	47	26	shifting	shifting	NN
cord-306948-wkisfz1m	47	27	in	in	IN
cord-306948-wkisfz1m	47	28	the	the	DT
cord-306948-wkisfz1m	47	29	ORF1a	ORF1a	NNP
cord-306948-wkisfz1m	47	30	/	/	SYM
cord-306948-wkisfz1m	47	31	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	47	32	overlapping	overlap	VBG
cord-306948-wkisfz1m	47	33	region	region	NN
cord-306948-wkisfz1m	47	34	(	(	-LRB-
cord-306948-wkisfz1m	47	35	Fig	Fig	NNP
cord-306948-wkisfz1m	47	36	.	.	.
cord-306948-wkisfz1m	47	37	1B	1B	NNP
cord-306948-wkisfz1m	47	38	;	;	:
cord-306948-wkisfz1m	47	39	den	den	NNP
cord-306948-wkisfz1m	47	40	Boon	Boon	NNP
cord-306948-wkisfz1m	47	41	et	et	NNP
cord-306948-wkisfz1m	47	42	al	al	NNP
cord-306948-wkisfz1m	47	43	.	.	NNP
cord-306948-wkisfz1m	47	44	,	,	,
cord-306948-wkisfz1m	47	45	1991	1991	CD
cord-306948-wkisfz1m	47	46	;	;	:
cord-306948-wkisfz1m	48	1	Snijder	Snijder	NNP
cord-306948-wkisfz1m	48	2	and	and	CC
cord-306948-wkisfz1m	48	3	Meulenberg	Meulenberg	NNP
cord-306948-wkisfz1m	48	4	,	,	,
cord-306948-wkisfz1m	48	5	1998	1998	CD
cord-306948-wkisfz1m	48	6	)	)	-RRB-
cord-306948-wkisfz1m	48	7	.	.	.
cord-306948-wkisfz1m	49	1	Thus	thus	RB
cord-306948-wkisfz1m	49	2	,	,	,
cord-306948-wkisfz1m	49	3	the	the	DT
cord-306948-wkisfz1m	49	4	pp1b	pp1b	NNP
cord-306948-wkisfz1m	49	5	portion	portion	NN
cord-306948-wkisfz1m	49	6	is	be	VBZ
cord-306948-wkisfz1m	49	7	expressed	express	VBN
cord-306948-wkisfz1m	49	8	always	always	RB
cord-306948-wkisfz1m	49	9	as	as	IN
cord-306948-wkisfz1m	49	10	a	a	DT
cord-306948-wkisfz1m	49	11	fusion	fusion	NN
cord-306948-wkisfz1m	49	12	with	with	IN
cord-306948-wkisfz1m	49	13	pp1a	pp1a	NNP
cord-306948-wkisfz1m	49	14	.	.	.
cord-306948-wkisfz1m	50	1	The	the	DT
cord-306948-wkisfz1m	50	2	pp1a	pp1a	NNP
cord-306948-wkisfz1m	50	3	and	and	CC
cord-306948-wkisfz1m	50	4	pp1ab	pp1ab	NNP
cord-306948-wkisfz1m	50	5	proteins	protein	NNS
cord-306948-wkisfz1m	50	6	are	be	VBP
cord-306948-wkisfz1m	50	7	further	further	RB
cord-306948-wkisfz1m	50	8	processed	process	VBN
cord-306948-wkisfz1m	50	9	to	to	TO
cord-306948-wkisfz1m	50	10	generate	generate	VB
cord-306948-wkisfz1m	50	11	14	14	CD
cord-306948-wkisfz1m	50	12	non	non	JJ
cord-306948-wkisfz1m	50	13	-	-	JJ
cord-306948-wkisfz1m	50	14	structural	structural	JJ
cord-306948-wkisfz1m	50	15	proteins	protein	NNS
cord-306948-wkisfz1m	50	16	(	(	-LRB-
cord-306948-wkisfz1m	50	17	nsps	nsps	NNP
cord-306948-wkisfz1m	50	18	)	)	-RRB-
cord-306948-wkisfz1m	50	19	.	.	.
cord-306948-wkisfz1m	51	1	The	the	DT
cord-306948-wkisfz1m	51	2	polyprotein	polyprotein	JJ
cord-306948-wkisfz1m	51	3	processing	processing	NN
cord-306948-wkisfz1m	51	4	scheme	scheme	NN
cord-306948-wkisfz1m	51	5	involves	involve	VBZ
cord-306948-wkisfz1m	51	6	the	the	DT
cord-306948-wkisfz1m	51	7	rapid	rapid	JJ
cord-306948-wkisfz1m	51	8	auto	auto	NN
cord-306948-wkisfz1m	51	9	-	-	HYPH
cord-306948-wkisfz1m	51	10	proteolytic	proteolytic	JJ
cord-306948-wkisfz1m	51	11	release	release	NN
cord-306948-wkisfz1m	51	12	of	of	IN
cord-306948-wkisfz1m	51	13	three	three	CD
cord-306948-wkisfz1m	51	14	Nterminal	Nterminal	NNP
cord-306948-wkisfz1m	51	15	nsps	nsp	NNS
cord-306948-wkisfz1m	51	16	,	,	,
cord-306948-wkisfz1m	51	17	nsp1a	nsp1a	NNP
cord-306948-wkisfz1m	51	18	,	,	,
cord-306948-wkisfz1m	51	19	nsp1b	nsp1b	NNP
cord-306948-wkisfz1m	51	20	,	,	,
cord-306948-wkisfz1m	51	21	and	and	CC
cord-306948-wkisfz1m	51	22	nsp2	nsp2	NNP
cord-306948-wkisfz1m	51	23	,	,	,
cord-306948-wkisfz1m	51	24	mediated	mediate	VBN
cord-306948-wkisfz1m	51	25	by	by	IN
cord-306948-wkisfz1m	51	26	papain	papain	NN
cord-306948-wkisfz1m	51	27	like	like	IN
cord-306948-wkisfz1m	51	28	proteinase	proteinase	NN
cord-306948-wkisfz1m	51	29	(	(	-LRB-
cord-306948-wkisfz1m	51	30	PLP	PLP	NNP
cord-306948-wkisfz1m	51	31	)	)	-RRB-
cord-306948-wkisfz1m	51	32	residing	reside	VBG
cord-306948-wkisfz1m	51	33	in	in	IN
cord-306948-wkisfz1m	51	34	each	each	DT
cord-306948-wkisfz1m	51	35	of	of	IN
cord-306948-wkisfz1m	51	36	them	-PRON-	PRP
cord-306948-wkisfz1m	51	37	.	.	.
cord-306948-wkisfz1m	52	1	The	the	DT
cord-306948-wkisfz1m	52	2	subsequent	subsequent	JJ
cord-306948-wkisfz1m	52	3	processing	processing	NN
cord-306948-wkisfz1m	52	4	for	for	IN
cord-306948-wkisfz1m	52	5	the	the	DT
cord-306948-wkisfz1m	52	6	remaining	remain	VBG
cord-306948-wkisfz1m	52	7	portion	portion	NN
cord-306948-wkisfz1m	52	8	of	of	IN
cord-306948-wkisfz1m	52	9	polyproteins	polyprotein	NNS
cord-306948-wkisfz1m	52	10	is	be	VBZ
cord-306948-wkisfz1m	52	11	mediated	mediate	VBN
cord-306948-wkisfz1m	52	12	by	by	IN
cord-306948-wkisfz1m	52	13	the	the	DT
cord-306948-wkisfz1m	52	14	serine	serine	NN
cord-306948-wkisfz1m	52	15	protease	protease	NN
cord-306948-wkisfz1m	52	16	in	in	IN
cord-306948-wkisfz1m	52	17	nsp4	nsp4	NNS
cord-306948-wkisfz1m	52	18	resulting	result	VBG
cord-306948-wkisfz1m	52	19	in	in	IN
cord-306948-wkisfz1m	52	20	14	14	CD
cord-306948-wkisfz1m	52	21	individual	individual	JJ
cord-306948-wkisfz1m	52	22	nsps	nsp	NNS
cord-306948-wkisfz1m	52	23	(	(	-LRB-
cord-306948-wkisfz1m	52	24	den	den	NNP
cord-306948-wkisfz1m	52	25	Boon	Boon	NNP
cord-306948-wkisfz1m	52	26	et	et	NNP
cord-306948-wkisfz1m	52	27	al	al	NNP
cord-306948-wkisfz1m	52	28	.	.	NNP
cord-306948-wkisfz1m	52	29	,	,	,
cord-306948-wkisfz1m	52	30	1995	1995	CD
cord-306948-wkisfz1m	52	31	;	;	:
cord-306948-wkisfz1m	52	32	van	van	NNP
cord-306948-wkisfz1m	52	33	Aken	Aken	NNP
cord-306948-wkisfz1m	52	34	et	et	NNP
cord-306948-wkisfz1m	52	35	al	al	NNP
cord-306948-wkisfz1m	52	36	.	.	NNP
cord-306948-wkisfz1m	52	37	,	,	,
cord-306948-wkisfz1m	52	38	2006	2006	CD
cord-306948-wkisfz1m	52	39	;	;	:
cord-306948-wkisfz1m	52	40	Ziebuhr	Ziebuhr	NNP
cord-306948-wkisfz1m	52	41	et	et	NNP
cord-306948-wkisfz1m	52	42	al	al	NNP
cord-306948-wkisfz1m	52	43	.	.	NNP
cord-306948-wkisfz1m	52	44	,	,	,
cord-306948-wkisfz1m	52	45	2000	2000	CD
cord-306948-wkisfz1m	52	46	)	)	-RRB-
cord-306948-wkisfz1m	52	47	.	.	.
cord-306948-wkisfz1m	53	1	The	the	DT
cord-306948-wkisfz1m	53	2	proteolytic	proteolytic	JJ
cord-306948-wkisfz1m	53	3	cleavages	cleavage	NNS
cord-306948-wkisfz1m	53	4	for	for	IN
cord-306948-wkisfz1m	53	5	individual	individual	JJ
cord-306948-wkisfz1m	53	6	nsps	nsp	NNS
cord-306948-wkisfz1m	53	7	were	be	VBD
cord-306948-wkisfz1m	53	8	initially	initially	RB
cord-306948-wkisfz1m	53	9	predicted	predict	VBN
cord-306948-wkisfz1m	53	10	by	by	IN
cord-306948-wkisfz1m	53	11	sequence	sequence	NN
cord-306948-wkisfz1m	53	12	comparisons	comparison	NNS
cord-306948-wkisfz1m	53	13	in	in	IN
cord-306948-wkisfz1m	53	14	combination	combination	NN
cord-306948-wkisfz1m	53	15	with	with	IN
cord-306948-wkisfz1m	53	16	some	some	DT
cord-306948-wkisfz1m	53	17	experimental	experimental	JJ
cord-306948-wkisfz1m	53	18	data	datum	NNS
cord-306948-wkisfz1m	53	19	from	from	IN
cord-306948-wkisfz1m	53	20	EAV	EAV	NNP
cord-306948-wkisfz1m	53	21	,	,	,
cord-306948-wkisfz1m	53	22	the	the	DT
cord-306948-wkisfz1m	53	23	prototype	prototype	NN
cord-306948-wkisfz1m	53	24	virus	virus	NN
cord-306948-wkisfz1m	53	25	of	of	IN
cord-306948-wkisfz1m	53	26	the	the	DT
cord-306948-wkisfz1m	53	27	family	family	NN
cord-306948-wkisfz1m	53	28	Arteriviridae	Arteriviridae	NNP
cord-306948-wkisfz1m	53	29	(	(	-LRB-
cord-306948-wkisfz1m	53	30	Fang	Fang	NNP
cord-306948-wkisfz1m	53	31	and	and	CC
cord-306948-wkisfz1m	53	32	Snijder	Snijder	NNP
cord-306948-wkisfz1m	53	33	,	,	,
cord-306948-wkisfz1m	53	34	2010	2010	CD
cord-306948-wkisfz1m	53	35	;	;	:
cord-306948-wkisfz1m	53	36	Ziebuhr	Ziebuhr	NNP
cord-306948-wkisfz1m	53	37	et	et	NNP
cord-306948-wkisfz1m	53	38	al	al	NNP
cord-306948-wkisfz1m	53	39	.	.	NNP
cord-306948-wkisfz1m	53	40	,	,	,
cord-306948-wkisfz1m	53	41	2000	2000	CD
cord-306948-wkisfz1m	53	42	)	)	-RRB-
cord-306948-wkisfz1m	53	43	.	.	.
cord-306948-wkisfz1m	54	1	The	the	DT
cord-306948-wkisfz1m	54	2	exact	exact	JJ
cord-306948-wkisfz1m	54	3	cleavage	cleavage	NN
cord-306948-wkisfz1m	54	4	sites	site	NNS
cord-306948-wkisfz1m	54	5	for	for	IN
cord-306948-wkisfz1m	54	6	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	55	1	nsp1a#nsp1b	nsp1a#nsp1b	NNP
cord-306948-wkisfz1m	55	2	and	and	CC
cord-306948-wkisfz1m	55	3	nsp1b#nsp2	nsp1b#nsp2	NNP
cord-306948-wkisfz1m	55	4	have	have	VBP
cord-306948-wkisfz1m	55	5	recently	recently	RB
cord-306948-wkisfz1m	55	6	been	be	VBN
cord-306948-wkisfz1m	55	7	confirmed	confirm	VBN
cord-306948-wkisfz1m	55	8	to	to	TO
cord-306948-wkisfz1m	55	9	be	be	VB
cord-306948-wkisfz1m	55	10	M180#A181	M180#A181	NNP
cord-306948-wkisfz1m	55	11	and	and	CC
cord-306948-wkisfz1m	55	12	G383#A384	G383#A384	NNS
cord-306948-wkisfz1m	55	13	mediated	mediate	VBN
cord-306948-wkisfz1m	55	14	by	by	IN
cord-306948-wkisfz1m	55	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	55	16	-	-	HYPH
cord-306948-wkisfz1m	55	17	PLP1a	PLP1a	NNP
cord-306948-wkisfz1m	55	18	and	and	CC
cord-306948-wkisfz1m	55	19	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	55	20	-	-	HYPH
cord-306948-wkisfz1m	55	21	PLP1b	PLP1b	NNP
cord-306948-wkisfz1m	55	22	,	,	,
cord-306948-wkisfz1m	55	23	respectively	respectively	RB
cord-306948-wkisfz1m	55	24	Sun	Sun	NNP
cord-306948-wkisfz1m	55	25	et	et	FW
cord-306948-wkisfz1m	55	26	al	al	NNP
cord-306948-wkisfz1m	55	27	.	.	.
cord-306948-wkisfz1m	56	1	,	,	,
cord-306948-wkisfz1m	56	2	2009	2009	CD
cord-306948-wkisfz1m	56	3	;	;	:
cord-306948-wkisfz1m	56	4	Xue	Xue	NNP
cord-306948-wkisfz1m	56	5	et	et	NNP
cord-306948-wkisfz1m	56	6	al	al	NNP
cord-306948-wkisfz1m	56	7	.	.	NNP
cord-306948-wkisfz1m	56	8	,	,	,
cord-306948-wkisfz1m	56	9	2010	2010	CD
cord-306948-wkisfz1m	56	10	)	)	-RRB-
cord-306948-wkisfz1m	56	11	.	.	.
cord-306948-wkisfz1m	57	1	A	a	DT
cord-306948-wkisfz1m	57	2	set	set	NN
cord-306948-wkisfz1m	57	3	of	of	IN
cord-306948-wkisfz1m	57	4	3	3	CD
cord-306948-wkisfz1m	57	5	0	0	CD
cord-306948-wkisfz1m	57	6	-coterminal	-coterminal	JJ
cord-306948-wkisfz1m	57	7	nested	nest	VBN
cord-306948-wkisfz1m	57	8	subgenomic	subgenomic	NNP
cord-306948-wkisfz1m	57	9	(	(	-LRB-
cord-306948-wkisfz1m	57	10	sg	sg	NNP
cord-306948-wkisfz1m	57	11	)	)	-RRB-
cord-306948-wkisfz1m	57	12	mRNAs	mRNAs	NNP
cord-306948-wkisfz1m	57	13	,	,	,
cord-306948-wkisfz1m	57	14	from	from	IN
cord-306948-wkisfz1m	57	15	which	which	WDT
cord-306948-wkisfz1m	57	16	structural	structural	JJ
cord-306948-wkisfz1m	57	17	proteins	protein	NNS
cord-306948-wkisfz1m	57	18	are	be	VBP
cord-306948-wkisfz1m	57	19	translated	translate	VBN
cord-306948-wkisfz1m	57	20	,	,	,
cord-306948-wkisfz1m	57	21	is	be	VBZ
cord-306948-wkisfz1m	57	22	produced	produce	VBN
cord-306948-wkisfz1m	57	23	during	during	IN
cord-306948-wkisfz1m	57	24	infection	infection	NN
cord-306948-wkisfz1m	57	25	(	(	-LRB-
cord-306948-wkisfz1m	57	26	Fig	fig	NN
cord-306948-wkisfz1m	57	27	.	.	.
cord-306948-wkisfz1m	57	28	1B	1b	CD
cord-306948-wkisfz1m	57	29	)	)	-RRB-
cord-306948-wkisfz1m	57	30	.	.	.
cord-306948-wkisfz1m	58	1	Each	each	DT
cord-306948-wkisfz1m	58	2	mRNA	mrna	NN
cord-306948-wkisfz1m	58	3	contains	contain	VBZ
cord-306948-wkisfz1m	58	4	a	a	DT
cord-306948-wkisfz1m	58	5	common	common	JJ
cord-306948-wkisfz1m	58	6	5	5	CD
cord-306948-wkisfz1m	58	7	0	0	CD
cord-306948-wkisfz1m	58	8	-end	-end	CD
cord-306948-wkisfz1m	58	9	leader	leader	NN
cord-306948-wkisfz1m	58	10	sequence	sequence	NN
cord-306948-wkisfz1m	58	11	identical	identical	JJ
cord-306948-wkisfz1m	58	12	to	to	IN
cord-306948-wkisfz1m	58	13	the	the	DT
cord-306948-wkisfz1m	58	14	5	5	CD
cord-306948-wkisfz1m	58	15	0proximal	0proximal	CD
cord-306948-wkisfz1m	58	16	part	part	NN
cord-306948-wkisfz1m	58	17	of	of	IN
cord-306948-wkisfz1m	58	18	the	the	DT
cord-306948-wkisfz1m	58	19	genome	genome	NN
cord-306948-wkisfz1m	58	20	and	and	CC
cord-306948-wkisfz1m	58	21	this	this	DT
cord-306948-wkisfz1m	58	22	sequence	sequence	NN
cord-306948-wkisfz1m	58	23	is	be	VBZ
cord-306948-wkisfz1m	58	24	referred	refer	VBN
cord-306948-wkisfz1m	58	25	to	to	IN
cord-306948-wkisfz1m	58	26	as	as	IN
cord-306948-wkisfz1m	58	27	transcription	transcription	NN
cord-306948-wkisfz1m	58	28	-	-	HYPH
cord-306948-wkisfz1m	58	29	regulatory	regulatory	JJ
cord-306948-wkisfz1m	58	30	sequence	sequence	NN
cord-306948-wkisfz1m	58	31	(	(	-LRB-
cord-306948-wkisfz1m	58	32	TRS	TRS	NNP
cord-306948-wkisfz1m	58	33	)	)	-RRB-
cord-306948-wkisfz1m	58	34	.	.	.
cord-306948-wkisfz1m	59	1	The	the	DT
cord-306948-wkisfz1m	59	2	fusion	fusion	NN
cord-306948-wkisfz1m	59	3	of	of	IN
cord-306948-wkisfz1m	59	4	the	the	DT
cord-306948-wkisfz1m	59	5	common	common	JJ
cord-306948-wkisfz1m	59	6	5	5	CD
cord-306948-wkisfz1m	59	7	0	0	CD
cord-306948-wkisfz1m	59	8	sequence	sequence	NN
cord-306948-wkisfz1m	59	9	(	(	-LRB-
cord-306948-wkisfz1m	59	10	leader	leader	NN
cord-306948-wkisfz1m	59	11	TRS	TRS	NNP
cord-306948-wkisfz1m	59	12	)	)	-RRB-
cord-306948-wkisfz1m	59	13	to	to	IN
cord-306948-wkisfz1m	59	14	the	the	DT
cord-306948-wkisfz1m	59	15	different	different	JJ
cord-306948-wkisfz1m	59	16	3	3	CD
cord-306948-wkisfz1m	59	17	0	0	CD
cord-306948-wkisfz1m	59	18	-body	-body	NN
cord-306948-wkisfz1m	59	19	segments	segment	NNS
cord-306948-wkisfz1m	59	20	of	of	IN
cord-306948-wkisfz1m	59	21	sg	sg	NNP
cord-306948-wkisfz1m	59	22	mRNAs	mRNAs	NNP
cord-306948-wkisfz1m	59	23	is	be	VBZ
cord-306948-wkisfz1m	59	24	mediated	mediate	VBN
cord-306948-wkisfz1m	59	25	by	by	IN
cord-306948-wkisfz1m	59	26	discontinuous	discontinuous	JJ
cord-306948-wkisfz1m	59	27	transcription	transcription	NN
cord-306948-wkisfz1m	59	28	which	which	WDT
cord-306948-wkisfz1m	59	29	is	be	VBZ
cord-306948-wkisfz1m	59	30	a	a	DT
cord-306948-wkisfz1m	59	31	common	common	JJ
cord-306948-wkisfz1m	59	32	strategy	strategy	NN
cord-306948-wkisfz1m	59	33	of	of	IN
cord-306948-wkisfz1m	59	34	nidoviruses	nidoviruse	NNS
cord-306948-wkisfz1m	59	35	(	(	-LRB-
cord-306948-wkisfz1m	59	36	Sawicki	Sawicki	NNP
cord-306948-wkisfz1m	59	37	et	et	NNP
cord-306948-wkisfz1m	59	38	al	al	NNP
cord-306948-wkisfz1m	59	39	.	.	NNP
cord-306948-wkisfz1m	59	40	,	,	,
cord-306948-wkisfz1m	59	41	2007	2007	CD
cord-306948-wkisfz1m	59	42	;	;	:
cord-306948-wkisfz1m	59	43	Snijder	Snijder	NNP
cord-306948-wkisfz1m	59	44	et	et	NNP
cord-306948-wkisfz1m	59	45	al	al	NNP
cord-306948-wkisfz1m	59	46	.	.	NNP
cord-306948-wkisfz1m	59	47	,	,	,
cord-306948-wkisfz1m	59	48	2013	2013	CD
cord-306948-wkisfz1m	59	49	;	;	:
cord-306948-wkisfz1m	59	50	Sola	Sola	NNP
cord-306948-wkisfz1m	59	51	et	et	FW
cord-306948-wkisfz1m	59	52	al	al	NNP
cord-306948-wkisfz1m	59	53	.	.	NNP
cord-306948-wkisfz1m	59	54	,	,	,
cord-306948-wkisfz1m	59	55	2011	2011	CD
cord-306948-wkisfz1m	59	56	)	)	-RRB-
cord-306948-wkisfz1m	59	57	.	.	.
cord-306948-wkisfz1m	60	1	During	during	IN
cord-306948-wkisfz1m	60	2	the	the	DT
cord-306948-wkisfz1m	60	3	negative	negative	JJ
cord-306948-wkisfz1m	60	4	-	-	HYPH
cord-306948-wkisfz1m	60	5	strand	strand	NN
cord-306948-wkisfz1m	60	6	sg	sg	NNP
cord-306948-wkisfz1m	60	7	RNA	RNA	NNP
cord-306948-wkisfz1m	60	8	synthesis	synthesis	NN
cord-306948-wkisfz1m	60	9	,	,	,
cord-306948-wkisfz1m	60	10	transcription	transcription	NN
cord-306948-wkisfz1m	60	11	is	be	VBZ
cord-306948-wkisfz1m	60	12	attenuated	attenuate	VBN
cord-306948-wkisfz1m	60	13	at	at	IN
cord-306948-wkisfz1m	60	14	different	different	JJ
cord-306948-wkisfz1m	60	15	body	body	NN
cord-306948-wkisfz1m	60	16	TRS	TRS	NNP
cord-306948-wkisfz1m	60	17	regions	region	NNS
cord-306948-wkisfz1m	60	18	of	of	IN
cord-306948-wkisfz1m	60	19	the	the	DT
cord-306948-wkisfz1m	60	20	genomic	genomic	JJ
cord-306948-wkisfz1m	60	21	template	template	NN
cord-306948-wkisfz1m	60	22	.	.	.
cord-306948-wkisfz1m	61	1	The	the	DT
cord-306948-wkisfz1m	61	2	nascent	nascent	JJ
cord-306948-wkisfz1m	61	3	subgenome	subgenome	NN
cord-306948-wkisfz1m	61	4	-	-	HYPH
cord-306948-wkisfz1m	61	5	length	length	NN
cord-306948-wkisfz1m	61	6	minus	minus	JJ
cord-306948-wkisfz1m	61	7	-	-	HYPH
cord-306948-wkisfz1m	61	8	strand	strand	NN
cord-306948-wkisfz1m	61	9	RNA	RNA	NNP
cord-306948-wkisfz1m	61	10	,	,	,
cord-306948-wkisfz1m	61	11	having	have	VBG
cord-306948-wkisfz1m	61	12	an	an	DT
cord-306948-wkisfz1m	61	13	antibody	antibody	NN
cord-306948-wkisfz1m	61	14	TRS	TRS	NNP
cord-306948-wkisfz1m	61	15	at	at	IN
cord-306948-wkisfz1m	61	16	its	-PRON-	PRP$
cord-306948-wkisfz1m	61	17	3	3	CD
cord-306948-wkisfz1m	61	18	0	0	CD
cord-306948-wkisfz1m	61	19	end	end	NN
cord-306948-wkisfz1m	61	20	,	,	,
cord-306948-wkisfz1m	61	21	will	will	MD
cord-306948-wkisfz1m	61	22	then	then	RB
cord-306948-wkisfz1m	61	23	move	move	VB
cord-306948-wkisfz1m	61	24	and	and	CC
cord-306948-wkisfz1m	61	25	base	base	NN
cord-306948-wkisfz1m	61	26	-	-	HYPH
cord-306948-wkisfz1m	61	27	pair	pair	NN
cord-306948-wkisfz1m	61	28	with	with	IN
cord-306948-wkisfz1m	61	29	the	the	DT
cord-306948-wkisfz1m	61	30	leader	leader	NN
cord-306948-wkisfz1m	61	31	TRS	TRS	NNP
cord-306948-wkisfz1m	61	32	and	and	CC
cord-306948-wkisfz1m	61	33	completes	complete	VBZ
cord-306948-wkisfz1m	61	34	the	the	DT
cord-306948-wkisfz1m	61	35	extension	extension	NN
cord-306948-wkisfz1m	61	36	of	of	IN
cord-306948-wkisfz1m	61	37	sg	sg	NNP
cord-306948-wkisfz1m	61	38	RNA	RNA	NNP
cord-306948-wkisfz1m	61	39	.	.	.
cord-306948-wkisfz1m	62	1	Minus	minus	JJ
cord-306948-wkisfz1m	62	2	-	-	HYPH
cord-306948-wkisfz1m	62	3	strand	strand	NN
cord-306948-wkisfz1m	62	4	sg	sg	NNP
cord-306948-wkisfz1m	62	5	RNAs	rna	NNS
cord-306948-wkisfz1m	62	6	subsequently	subsequently	RB
cord-306948-wkisfz1m	62	7	serve	serve	VBP
cord-306948-wkisfz1m	62	8	as	as	IN
cord-306948-wkisfz1m	62	9	a	a	DT
cord-306948-wkisfz1m	62	10	template	template	NN
cord-306948-wkisfz1m	62	11	for	for	IN
cord-306948-wkisfz1m	62	12	plus	plus	JJ
cord-306948-wkisfz1m	62	13	-	-	HYPH
cord-306948-wkisfz1m	62	14	strand	strand	NN
cord-306948-wkisfz1m	62	15	sg	sg	NNP
cord-306948-wkisfz1m	62	16	mRNA	mRNA	NNP
cord-306948-wkisfz1m	62	17	which	which	WDT
cord-306948-wkisfz1m	62	18	is	be	VBZ
cord-306948-wkisfz1m	62	19	subsequently	subsequently	RB
cord-306948-wkisfz1m	62	20	translated	translate	VBN
cord-306948-wkisfz1m	62	21	for	for	IN
cord-306948-wkisfz1m	62	22	structural	structural	JJ
cord-306948-wkisfz1m	62	23	protein	protein	NN
cord-306948-wkisfz1m	62	24	(	(	-LRB-
cord-306948-wkisfz1m	62	25	Music	Music	NNP
cord-306948-wkisfz1m	62	26	and	and	CC
cord-306948-wkisfz1m	62	27	Gagnon	Gagnon	NNP
cord-306948-wkisfz1m	62	28	,	,	,
cord-306948-wkisfz1m	62	29	2010	2010	CD
cord-306948-wkisfz1m	62	30	;	;	.
cord-306948-wkisfz1m	63	1	Sawicki	Sawicki	NNP
cord-306948-wkisfz1m	63	2	et	et	NNP
cord-306948-wkisfz1m	63	3	al	al	NNP
cord-306948-wkisfz1m	63	4	.	.	NNP
cord-306948-wkisfz1m	63	5	,	,	,
cord-306948-wkisfz1m	63	6	2007	2007	CD
cord-306948-wkisfz1m	63	7	;	;	:
cord-306948-wkisfz1m	63	8	Snijder	Snijder	NNP
cord-306948-wkisfz1m	63	9	et	et	NNP
cord-306948-wkisfz1m	63	10	al	al	NNP
cord-306948-wkisfz1m	63	11	.	.	NNP
cord-306948-wkisfz1m	63	12	,	,	,
cord-306948-wkisfz1m	63	13	2013	2013	CD
cord-306948-wkisfz1m	63	14	)	)	-RRB-
cord-306948-wkisfz1m	63	15	.	.	.
cord-306948-wkisfz1m	64	1	The	the	DT
cord-306948-wkisfz1m	64	2	genome	genome	NN
cord-306948-wkisfz1m	64	3	of	of	IN
cord-306948-wkisfz1m	64	4	negative	negative	JJ
cord-306948-wkisfz1m	64	5	-	-	HYPH
cord-306948-wkisfz1m	64	6	strand	strand	NN
cord-306948-wkisfz1m	64	7	RNA	RNA	NNP
cord-306948-wkisfz1m	64	8	viruses	virus	NNS
cord-306948-wkisfz1m	64	9	is	be	VBZ
cord-306948-wkisfz1m	64	10	noninfectious	noninfectious	JJ
cord-306948-wkisfz1m	64	11	,	,	,
cord-306948-wkisfz1m	64	12	and	and	CC
cord-306948-wkisfz1m	64	13	its	-PRON-	PRP$
cord-306948-wkisfz1m	64	14	replication	replication	NN
cord-306948-wkisfz1m	64	15	in	in	IN
cord-306948-wkisfz1m	64	16	permissive	permissive	JJ
cord-306948-wkisfz1m	64	17	cells	cell	NNS
cord-306948-wkisfz1m	64	18	requires	require	VBZ
cord-306948-wkisfz1m	64	19	the	the	DT
cord-306948-wkisfz1m	64	20	ribonucleoprotein	ribonucleoprotein	NN
cord-306948-wkisfz1m	64	21	(	(	-LRB-
cord-306948-wkisfz1m	64	22	RNP	RNP	NNP
cord-306948-wkisfz1m	64	23	)	)	-RRB-
cord-306948-wkisfz1m	64	24	complex	complex	JJ
cord-306948-wkisfz1m	64	25	as	as	IN
cord-306948-wkisfz1m	64	26	the	the	DT
cord-306948-wkisfz1m	64	27	infectious	infectious	JJ
cord-306948-wkisfz1m	64	28	unit	unit	NN
cord-306948-wkisfz1m	64	29	.	.	.
cord-306948-wkisfz1m	65	1	In	in	IN
cord-306948-wkisfz1m	65	2	contrast	contrast	NN
cord-306948-wkisfz1m	65	3	,	,	,
cord-306948-wkisfz1m	65	4	the	the	DT
cord-306948-wkisfz1m	65	5	genome	genome	NN
cord-306948-wkisfz1m	65	6	from	from	IN
cord-306948-wkisfz1m	65	7	positive	positive	JJ
cord-306948-wkisfz1m	65	8	-	-	HYPH
cord-306948-wkisfz1m	65	9	strand	strand	NN
cord-306948-wkisfz1m	65	10	RNA	RNA	NNP
cord-306948-wkisfz1m	65	11	viruses	virus	NNS
cord-306948-wkisfz1m	65	12	is	be	VBZ
cord-306948-wkisfz1m	65	13	fully	fully	RB
cord-306948-wkisfz1m	65	14	infectious	infectious	JJ
cord-306948-wkisfz1m	65	15	,	,	,
cord-306948-wkisfz1m	65	16	and	and	CC
cord-306948-wkisfz1m	65	17	thus	thus	RB
cord-306948-wkisfz1m	65	18	the	the	DT
cord-306948-wkisfz1m	65	19	assemly	assemly	NN
cord-306948-wkisfz1m	65	20	of	of	IN
cord-306948-wkisfz1m	65	21	full	full	JJ
cord-306948-wkisfz1m	65	22	-	-	HYPH
cord-306948-wkisfz1m	65	23	length	length	NN
cord-306948-wkisfz1m	65	24	cDNA	cdna	NN
cord-306948-wkisfz1m	65	25	clones	clone	NNS
cord-306948-wkisfz1m	65	26	corresponding	correspond	VBG
cord-306948-wkisfz1m	65	27	to	to	IN
cord-306948-wkisfz1m	65	28	the	the	DT
cord-306948-wkisfz1m	65	29	RNA	RNA	NNP
cord-306948-wkisfz1m	65	30	genome	genome	NN
cord-306948-wkisfz1m	65	31	is	be	VBZ
cord-306948-wkisfz1m	65	32	the	the	DT
cord-306948-wkisfz1m	65	33	kernel	kernel	NN
cord-306948-wkisfz1m	65	34	to	to	IN
cord-306948-wkisfz1m	65	35	the	the	DT
cord-306948-wkisfz1m	65	36	construction	construction	NN
cord-306948-wkisfz1m	65	37	of	of	IN
cord-306948-wkisfz1m	65	38	infectious	infectious	JJ
cord-306948-wkisfz1m	65	39	clones	clone	NNS
cord-306948-wkisfz1m	65	40	.	.	.
cord-306948-wkisfz1m	66	1	The	the	DT
cord-306948-wkisfz1m	66	2	viral	viral	JJ
cord-306948-wkisfz1m	66	3	genome	genome	NN
cord-306948-wkisfz1m	66	4	is	be	VBZ
cord-306948-wkisfz1m	66	5	polycistronic	polycistronic	JJ
cord-306948-wkisfz1m	66	6	,	,	,
cord-306948-wkisfz1m	66	7	harboring	harbor	VBG
cord-306948-wkisfz1m	66	8	ORF1a	ORF1a	NNP
cord-306948-wkisfz1m	66	9	and	and	CC
cord-306948-wkisfz1m	66	10	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	66	11	,	,	,
cord-306948-wkisfz1m	66	12	and	and	CC
cord-306948-wkisfz1m	66	13	structural	structural	JJ
cord-306948-wkisfz1m	66	14	genes	gene	NNS
cord-306948-wkisfz1m	66	15	of	of	IN
cord-306948-wkisfz1m	66	16	ORF2a	ORF2a	NNP
cord-306948-wkisfz1m	66	17	,	,	,
cord-306948-wkisfz1m	66	18	ORF2b	ORF2b	NNP
cord-306948-wkisfz1m	66	19	,	,	,
cord-306948-wkisfz1m	66	20	and	and	CC
cord-306948-wkisfz1m	66	21	ORFs	ORFs	NNP
cord-306948-wkisfz1m	66	22	3	3	CD
cord-306948-wkisfz1m	66	23	through	through	IN
cord-306948-wkisfz1m	66	24	7	7	CD
cord-306948-wkisfz1m	66	25	,	,	,
cord-306948-wkisfz1m	66	26	plus	plus	CC
cord-306948-wkisfz1m	66	27	ORF5a	ORF5a	NNP
cord-306948-wkisfz1m	66	28	within	within	IN
cord-306948-wkisfz1m	66	29	ORF5	ORF5	NNP
cord-306948-wkisfz1m	66	30	.	.	.
cord-306948-wkisfz1m	67	1	(	(	-LRB-
cord-306948-wkisfz1m	67	2	B	b	NN
cord-306948-wkisfz1m	67	3	)	)	-RRB-
cord-306948-wkisfz1m	67	4	Viral	viral	JJ
cord-306948-wkisfz1m	67	5	gene	gene	NN
cord-306948-wkisfz1m	67	6	expression	expression	NN
cord-306948-wkisfz1m	67	7	.	.	.
cord-306948-wkisfz1m	68	1	Non	non	JJ
cord-306948-wkisfz1m	68	2	-	-	JJ
cord-306948-wkisfz1m	68	3	structural	structural	JJ
cord-306948-wkisfz1m	68	4	proteins	protein	NNS
cord-306948-wkisfz1m	68	5	(	(	-LRB-
cord-306948-wkisfz1m	68	6	black	black	JJ
cord-306948-wkisfz1m	68	7	)	)	-RRB-
cord-306948-wkisfz1m	68	8	are	be	VBP
cord-306948-wkisfz1m	68	9	produced	produce	VBN
cord-306948-wkisfz1m	68	10	from	from	IN
cord-306948-wkisfz1m	68	11	pp1a	pp1a	NNP
cord-306948-wkisfz1m	68	12	and	and	CC
cord-306948-wkisfz1m	68	13	pp1ab	pp1ab	NNP
cord-306948-wkisfz1m	68	14	after	after	IN
cord-306948-wkisfz1m	68	15	proteolytic	proteolytic	JJ
cord-306948-wkisfz1m	68	16	processing	processing	NN
cord-306948-wkisfz1m	68	17	.	.	.
cord-306948-wkisfz1m	69	1	The	the	DT
cord-306948-wkisfz1m	69	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	69	3	replicase	replicase	NN
cord-306948-wkisfz1m	69	4	-	-	HYPH
cord-306948-wkisfz1m	69	5	processing	process	VBG
cord-306948-wkisfz1m	69	6	scheme	scheme	NN
cord-306948-wkisfz1m	69	7	involves	involve	VBZ
cord-306948-wkisfz1m	69	8	the	the	DT
cord-306948-wkisfz1m	69	9	rapid	rapid	JJ
cord-306948-wkisfz1m	69	10	auto	auto	NN
cord-306948-wkisfz1m	69	11	-	-	HYPH
cord-306948-wkisfz1m	69	12	proteolytic	proteolytic	JJ
cord-306948-wkisfz1m	69	13	release	release	NN
cord-306948-wkisfz1m	69	14	of	of	IN
cord-306948-wkisfz1m	69	15	nsp1a	nsp1a	NNS
cord-306948-wkisfz1m	69	16	,	,	,
cord-306948-wkisfz1m	69	17	nsp1b	nsp1b	NNP
cord-306948-wkisfz1m	69	18	,	,	,
cord-306948-wkisfz1m	69	19	and	and	CC
cord-306948-wkisfz1m	69	20	nsp2	nsp2	NNP
cord-306948-wkisfz1m	69	21	(	(	-LRB-
cord-306948-wkisfz1m	69	22	yellow	yellow	JJ
cord-306948-wkisfz1m	69	23	boxes	box	NNS
cord-306948-wkisfz1m	69	24	)	)	-RRB-
cord-306948-wkisfz1m	69	25	,	,	,
cord-306948-wkisfz1m	69	26	mediated	mediate	VBN
cord-306948-wkisfz1m	69	27	by	by	IN
cord-306948-wkisfz1m	69	28	papain	papain	NN
cord-306948-wkisfz1m	69	29	-	-	HYPH
cord-306948-wkisfz1m	69	30	like	like	JJ
cord-306948-wkisfz1m	69	31	proteinase	proteinase	NN
cord-306948-wkisfz1m	69	32	(	(	-LRB-
cord-306948-wkisfz1m	69	33	PLP	PLP	NNP
cord-306948-wkisfz1m	69	34	)	)	-RRB-
cord-306948-wkisfz1m	69	35	domains	domain	NNS
cord-306948-wkisfz1m	69	36	residing	reside	VBG
cord-306948-wkisfz1m	69	37	in	in	IN
cord-306948-wkisfz1m	69	38	each	each	DT
cord-306948-wkisfz1m	69	39	of	of	IN
cord-306948-wkisfz1m	69	40	them	-PRON-	PRP
cord-306948-wkisfz1m	69	41	.	.	.
cord-306948-wkisfz1m	70	1	The	the	DT
cord-306948-wkisfz1m	70	2	remaining	remain	VBG
cord-306948-wkisfz1m	70	3	polyproteins	polyprotein	NNS
cord-306948-wkisfz1m	70	4	are	be	VBP
cord-306948-wkisfz1m	70	5	processed	process	VBN
cord-306948-wkisfz1m	70	6	by	by	IN
cord-306948-wkisfz1m	70	7	nsp4	nsp4	NNS
cord-306948-wkisfz1m	70	8	,	,	,
cord-306948-wkisfz1m	70	9	resulting	result	VBG
cord-306948-wkisfz1m	70	10	in	in	IN
cord-306948-wkisfz1m	70	11	a	a	DT
cord-306948-wkisfz1m	70	12	set	set	NN
cord-306948-wkisfz1m	70	13	of	of	IN
cord-306948-wkisfz1m	70	14	14	14	CD
cord-306948-wkisfz1m	70	15	individual	individual	JJ
cord-306948-wkisfz1m	70	16	nsps	nsp	NNS
cord-306948-wkisfz1m	70	17	.	.	.
cord-306948-wkisfz1m	71	1	The	the	DT
cord-306948-wkisfz1m	71	2	cleavage	cleavage	NN
cord-306948-wkisfz1m	71	3	sites	site	NNS
cord-306948-wkisfz1m	71	4	by	by	IN
cord-306948-wkisfz1m	71	5	PLPs	plp	NNS
cord-306948-wkisfz1m	71	6	and	and	CC
cord-306948-wkisfz1m	71	7	nsp4	nsp4	NNS
cord-306948-wkisfz1m	71	8	are	be	VBP
cord-306948-wkisfz1m	71	9	annotated	annotate	VBN
cord-306948-wkisfz1m	71	10	by	by	IN
cord-306948-wkisfz1m	71	11	curved	curved	JJ
cord-306948-wkisfz1m	71	12	arrows	arrow	NNS
cord-306948-wkisfz1m	71	13	and	and	CC
cord-306948-wkisfz1m	71	14	blue	blue	JJ
cord-306948-wkisfz1m	71	15	triangles	triangle	NNS
cord-306948-wkisfz1m	71	16	,	,	,
cord-306948-wkisfz1m	71	17	respectively	respectively	RB
cord-306948-wkisfz1m	71	18	.	.	.
cord-306948-wkisfz1m	72	1	Structural	structural	JJ
cord-306948-wkisfz1m	72	2	proteins	protein	NNS
cord-306948-wkisfz1m	72	3	(	(	-LRB-
cord-306948-wkisfz1m	72	4	color	color	NN
cord-306948-wkisfz1m	72	5	-	-	HYPH
cord-306948-wkisfz1m	72	6	coded	code	VBN
cord-306948-wkisfz1m	72	7	)	)	-RRB-
cord-306948-wkisfz1m	72	8	are	be	VBP
cord-306948-wkisfz1m	72	9	expressed	express	VBN
cord-306948-wkisfz1m	72	10	from	from	IN
cord-306948-wkisfz1m	72	11	the	the	DT
cord-306948-wkisfz1m	72	12	subset	subset	NN
cord-306948-wkisfz1m	72	13	of	of	IN
cord-306948-wkisfz1m	72	14	sg	sg	NNP
cord-306948-wkisfz1m	72	15	mRNA	mRNA	NNP
cord-306948-wkisfz1m	72	16	.	.	.
cord-306948-wkisfz1m	73	1	The	the	DT
cord-306948-wkisfz1m	73	2	3	3	CD
cord-306948-wkisfz1m	73	3	0	0	CD
cord-306948-wkisfz1m	73	4	-co	-co	:
cord-306948-wkisfz1m	73	5	-	-	HYPH
cord-306948-wkisfz1m	73	6	terminal	terminal	NN
cord-306948-wkisfz1m	73	7	nested	nest	VBN
cord-306948-wkisfz1m	73	8	set	set	NN
cord-306948-wkisfz1m	73	9	of	of	IN
cord-306948-wkisfz1m	73	10	minus	minus	JJ
cord-306948-wkisfz1m	73	11	-	-	HYPH
cord-306948-wkisfz1m	73	12	strand	strand	NN
cord-306948-wkisfz1m	73	13	RNAs	rna	NNS
cord-306948-wkisfz1m	73	14	is	be	VBZ
cord-306948-wkisfz1m	73	15	produced	produce	VBN
cord-306948-wkisfz1m	73	16	as	as	IN
cord-306948-wkisfz1m	73	17	a	a	DT
cord-306948-wkisfz1m	73	18	template	template	NN
cord-306948-wkisfz1m	73	19	for	for	IN
cord-306948-wkisfz1m	73	20	plus	plus	NN
cord-306948-wkisfz1m	73	21	-	-	HYPH
cord-306948-wkisfz1m	73	22	strand	strand	NN
cord-306948-wkisfz1m	74	1	sg	sg	NNP
cord-306948-wkisfz1m	74	2	mRNA	mRNA	NNP
cord-306948-wkisfz1m	74	3	synthesis	synthesis	NN
cord-306948-wkisfz1m	74	4	.	.	.
cord-306948-wkisfz1m	75	1	TRS	TRS	NNP
cord-306948-wkisfz1m	75	2	,	,	,
cord-306948-wkisfz1m	75	3	transcription	transcription	NN
cord-306948-wkisfz1m	75	4	regulatory	regulatory	JJ
cord-306948-wkisfz1m	75	5	sequence	sequence	NN
cord-306948-wkisfz1m	75	6	.	.	.
cord-306948-wkisfz1m	76	1	(	(	-LRB-
cord-306948-wkisfz1m	76	2	For	for	IN
cord-306948-wkisfz1m	76	3	interpretation	interpretation	NN
cord-306948-wkisfz1m	76	4	of	of	IN
cord-306948-wkisfz1m	76	5	the	the	DT
cord-306948-wkisfz1m	76	6	references	reference	NNS
cord-306948-wkisfz1m	76	7	to	to	TO
cord-306948-wkisfz1m	76	8	colour	colour	VB
cord-306948-wkisfz1m	76	9	in	in	IN
cord-306948-wkisfz1m	76	10	this	this	DT
cord-306948-wkisfz1m	76	11	figure	figure	NN
cord-306948-wkisfz1m	76	12	legend	legend	NN
cord-306948-wkisfz1m	76	13	,	,	,
cord-306948-wkisfz1m	76	14	the	the	DT
cord-306948-wkisfz1m	76	15	reader	reader	NN
cord-306948-wkisfz1m	76	16	is	be	VBZ
cord-306948-wkisfz1m	76	17	referred	refer	VBN
cord-306948-wkisfz1m	76	18	to	to	IN
cord-306948-wkisfz1m	76	19	the	the	DT
cord-306948-wkisfz1m	76	20	web	web	NN
cord-306948-wkisfz1m	76	21	version	version	NN
cord-306948-wkisfz1m	76	22	of	of	IN
cord-306948-wkisfz1m	76	23	this	this	DT
cord-306948-wkisfz1m	76	24	article	article	NN
cord-306948-wkisfz1m	76	25	.	.	.
cord-306948-wkisfz1m	76	26	)	)	-RRB-
cord-306948-wkisfz1m	77	1	(	(	-LRB-
cord-306948-wkisfz1m	77	2	Boyer	Boyer	NNP
cord-306948-wkisfz1m	77	3	and	and	CC
cord-306948-wkisfz1m	77	4	Haenni	Haenni	NNP
cord-306948-wkisfz1m	77	5	,	,	,
cord-306948-wkisfz1m	77	6	1994	1994	CD
cord-306948-wkisfz1m	77	7	;	;	:
cord-306948-wkisfz1m	77	8	Meyers	Meyers	NNP
cord-306948-wkisfz1m	77	9	et	et	NNP
cord-306948-wkisfz1m	77	10	al	al	NNP
cord-306948-wkisfz1m	77	11	.	.	NNP
cord-306948-wkisfz1m	77	12	,	,	,
cord-306948-wkisfz1m	77	13	1997	1997	CD
cord-306948-wkisfz1m	77	14	;	;	:
cord-306948-wkisfz1m	77	15	Moormann	Moormann	NNP
cord-306948-wkisfz1m	77	16	et	et	NNP
cord-306948-wkisfz1m	77	17	al	al	NNP
cord-306948-wkisfz1m	77	18	.	.	.
cord-306948-wkisfz1m	78	1	,	,	,
cord-306948-wkisfz1m	78	2	1996	1996	CD
cord-306948-wkisfz1m	78	3	;	;	:
cord-306948-wkisfz1m	78	4	Sosnovtsev	Sosnovtsev	NNP
cord-306948-wkisfz1m	78	5	and	and	CC
cord-306948-wkisfz1m	78	6	Green	Green	NNP
cord-306948-wkisfz1m	78	7	,	,	,
cord-306948-wkisfz1m	78	8	1995	1995	CD
cord-306948-wkisfz1m	78	9	;	;	:
cord-306948-wkisfz1m	78	10	van	van	NNP
cord-306948-wkisfz1m	78	11	Dinten	Dinten	NNP
cord-306948-wkisfz1m	78	12	et	et	FW
cord-306948-wkisfz1m	78	13	al	al	NNP
cord-306948-wkisfz1m	78	14	.	.	NNP
cord-306948-wkisfz1m	78	15	,	,	,
cord-306948-wkisfz1m	78	16	1997	1997	CD
cord-306948-wkisfz1m	78	17	)	)	-RRB-
cord-306948-wkisfz1m	78	18	.	.	.
cord-306948-wkisfz1m	79	1	Non	non	JJ
cord-306948-wkisfz1m	79	2	-	-	JJ
cord-306948-wkisfz1m	79	3	retroviral	retroviral	JJ
cord-306948-wkisfz1m	79	4	RNA	RNA	NNP
cord-306948-wkisfz1m	79	5	viruses	virus	NNS
cord-306948-wkisfz1m	79	6	do	do	VBP
cord-306948-wkisfz1m	79	7	not	not	RB
cord-306948-wkisfz1m	79	8	undergo	undergo	VB
cord-306948-wkisfz1m	79	9	a	a	DT
cord-306948-wkisfz1m	79	10	DNA	dna	NN
cord-306948-wkisfz1m	79	11	intermediate	intermediate	JJ
cord-306948-wkisfz1m	79	12	step	step	NN
cord-306948-wkisfz1m	79	13	in	in	IN
cord-306948-wkisfz1m	79	14	their	-PRON-	PRP$
cord-306948-wkisfz1m	79	15	replication	replication	NN
cord-306948-wkisfz1m	79	16	cycle	cycle	NN
cord-306948-wkisfz1m	79	17	.	.	.
cord-306948-wkisfz1m	80	1	To	to	TO
cord-306948-wkisfz1m	80	2	obtain	obtain	VB
cord-306948-wkisfz1m	80	3	a	a	DT
cord-306948-wkisfz1m	80	4	template	template	NN
cord-306948-wkisfz1m	80	5	which	which	WDT
cord-306948-wkisfz1m	80	6	can	can	MD
cord-306948-wkisfz1m	80	7	be	be	VB
cord-306948-wkisfz1m	80	8	manipulated	manipulate	VBN
cord-306948-wkisfz1m	80	9	by	by	IN
cord-306948-wkisfz1m	80	10	molecular	molecular	JJ
cord-306948-wkisfz1m	80	11	techniques	technique	NNS
cord-306948-wkisfz1m	80	12	,	,	,
cord-306948-wkisfz1m	80	13	a	a	DT
cord-306948-wkisfz1m	80	14	full	full	JJ
cord-306948-wkisfz1m	80	15	-	-	HYPH
cord-306948-wkisfz1m	80	16	length	length	NN
cord-306948-wkisfz1m	80	17	cDNA	cdna	NN
cord-306948-wkisfz1m	80	18	clone	clone	NN
cord-306948-wkisfz1m	80	19	is	be	VBZ
cord-306948-wkisfz1m	80	20	first	first	RB
cord-306948-wkisfz1m	80	21	generated	generate	VBN
cord-306948-wkisfz1m	80	22	using	use	VBG
cord-306948-wkisfz1m	80	23	the	the	DT
cord-306948-wkisfz1m	80	24	reverse	reverse	JJ
cord-306948-wkisfz1m	80	25	transcriptase	transcriptase	NN
cord-306948-wkisfz1m	80	26	and	and	CC
cord-306948-wkisfz1m	80	27	DNA	dna	NN
cord-306948-wkisfz1m	80	28	polymerase	polymerase	NN
cord-306948-wkisfz1m	80	29	.	.	.
cord-306948-wkisfz1m	81	1	Once	once	RB
cord-306948-wkisfz1m	81	2	generated	generate	VBN
cord-306948-wkisfz1m	81	3	,	,	,
cord-306948-wkisfz1m	81	4	two	two	CD
cord-306948-wkisfz1m	81	5	strategies	strategy	NNS
cord-306948-wkisfz1m	81	6	have	have	VBP
cord-306948-wkisfz1m	81	7	been	be	VBN
cord-306948-wkisfz1m	81	8	established	establish	VBN
cord-306948-wkisfz1m	81	9	to	to	TO
cord-306948-wkisfz1m	81	10	generate	generate	VB
cord-306948-wkisfz1m	81	11	virus	virus	NN
cord-306948-wkisfz1m	81	12	progeny	progeny	NN
cord-306948-wkisfz1m	81	13	from	from	IN
cord-306948-wkisfz1m	81	14	the	the	DT
cord-306948-wkisfz1m	81	15	full	full	JJ
cord-306948-wkisfz1m	81	16	-	-	HYPH
cord-306948-wkisfz1m	81	17	length	length	NN
cord-306948-wkisfz1m	81	18	copy	copy	NN
cord-306948-wkisfz1m	81	19	of	of	IN
cord-306948-wkisfz1m	81	20	viral	viral	JJ
cord-306948-wkisfz1m	81	21	genome	genome	NN
cord-306948-wkisfz1m	81	22	:	:	:
cord-306948-wkisfz1m	81	23	RNA	rna	NN
cord-306948-wkisfz1m	81	24	transfection	transfection	NN
cord-306948-wkisfz1m	81	25	and	and	CC
cord-306948-wkisfz1m	81	26	DNA	dna	NN
cord-306948-wkisfz1m	81	27	transfection	transfection	NN
cord-306948-wkisfz1m	81	28	.	.	.
cord-306948-wkisfz1m	82	1	In	in	IN
cord-306948-wkisfz1m	82	2	the	the	DT
cord-306948-wkisfz1m	82	3	RNA	RNA	NNP
cord-306948-wkisfz1m	82	4	transfection	transfection	NN
cord-306948-wkisfz1m	82	5	strategy	strategy	NN
cord-306948-wkisfz1m	82	6	,	,	,
cord-306948-wkisfz1m	82	7	viral	viral	JJ
cord-306948-wkisfz1m	82	8	RNA	RNA	NNP
cord-306948-wkisfz1m	82	9	is	be	VBZ
cord-306948-wkisfz1m	82	10	synthesized	synthesize	VBN
cord-306948-wkisfz1m	82	11	by	by	IN
cord-306948-wkisfz1m	82	12	in	in	IN
cord-306948-wkisfz1m	82	13	vitro	vitro	FW
cord-306948-wkisfz1m	82	14	transcription	transcription	NN
cord-306948-wkisfz1m	82	15	using	use	VBG
cord-306948-wkisfz1m	82	16	T7	T7	NNP
cord-306948-wkisfz1m	82	17	or	or	CC
cord-306948-wkisfz1m	82	18	SP6	SP6	NNP
cord-306948-wkisfz1m	82	19	RNA	RNA	NNP
cord-306948-wkisfz1m	82	20	polymerase	polymerase	NN
cord-306948-wkisfz1m	82	21	coupled	couple	VBN
cord-306948-wkisfz1m	82	22	with	with	IN
cord-306948-wkisfz1m	82	23	the	the	DT
cord-306948-wkisfz1m	82	24	respective	respective	JJ
cord-306948-wkisfz1m	82	25	promoter	promoter	NN
cord-306948-wkisfz1m	82	26	located	locate	VBN
cord-306948-wkisfz1m	82	27	immediately	immediately	RB
cord-306948-wkisfz1m	82	28	upstream	upstream	RB
cord-306948-wkisfz1m	82	29	of	of	IN
cord-306948-wkisfz1m	82	30	the	the	DT
cord-306948-wkisfz1m	82	31	viral	viral	JJ
cord-306948-wkisfz1m	82	32	genome	genome	NN
cord-306948-wkisfz1m	82	33	.	.	.
cord-306948-wkisfz1m	83	1	The	the	DT
cord-306948-wkisfz1m	83	2	synthesized	synthesize	VBN
cord-306948-wkisfz1m	83	3	RNA	RNA	NNP
cord-306948-wkisfz1m	83	4	genome	genome	NN
cord-306948-wkisfz1m	83	5	is	be	VBZ
cord-306948-wkisfz1m	83	6	then	then	RB
cord-306948-wkisfz1m	83	7	introduced	introduce	VBN
cord-306948-wkisfz1m	83	8	into	into	IN
cord-306948-wkisfz1m	83	9	cells	cell	NNS
cord-306948-wkisfz1m	83	10	to	to	TO
cord-306948-wkisfz1m	83	11	initiate	initiate	VB
cord-306948-wkisfz1m	83	12	an	an	DT
cord-306948-wkisfz1m	83	13	infection	infection	NN
cord-306948-wkisfz1m	83	14	cycle	cycle	NN
cord-306948-wkisfz1m	83	15	.	.	.
cord-306948-wkisfz1m	84	1	In	in	IN
cord-306948-wkisfz1m	84	2	the	the	DT
cord-306948-wkisfz1m	84	3	DNA	dna	NN
cord-306948-wkisfz1m	84	4	launch	launch	NN
cord-306948-wkisfz1m	84	5	strategy	strategy	NN
cord-306948-wkisfz1m	84	6	,	,	,
cord-306948-wkisfz1m	84	7	a	a	DT
cord-306948-wkisfz1m	84	8	full	full	JJ
cord-306948-wkisfz1m	84	9	-	-	HYPH
cord-306948-wkisfz1m	84	10	length	length	NN
cord-306948-wkisfz1m	84	11	genomic	genomic	JJ
cord-306948-wkisfz1m	84	12	clone	clone	NN
cord-306948-wkisfz1m	84	13	is	be	VBZ
cord-306948-wkisfz1m	84	14	placed	place	VBN
cord-306948-wkisfz1m	84	15	under	under	IN
cord-306948-wkisfz1m	84	16	a	a	DT
cord-306948-wkisfz1m	84	17	eukaryotic	eukaryotic	JJ
cord-306948-wkisfz1m	84	18	promoter	promoter	NN
cord-306948-wkisfz1m	84	19	such	such	JJ
cord-306948-wkisfz1m	84	20	as	as	IN
cord-306948-wkisfz1m	84	21	a	a	DT
cord-306948-wkisfz1m	84	22	cytomegalovirus	cytomegalovirus	NN
cord-306948-wkisfz1m	84	23	(	(	-LRB-
cord-306948-wkisfz1m	84	24	CMV	CMV	NNP
cord-306948-wkisfz1m	84	25	)	)	-RRB-
cord-306948-wkisfz1m	84	26	promoter	promoter	NN
cord-306948-wkisfz1m	84	27	and	and	CC
cord-306948-wkisfz1m	84	28	the	the	DT
cord-306948-wkisfz1m	84	29	entire	entire	JJ
cord-306948-wkisfz1m	84	30	plasmid	plasmid	NN
cord-306948-wkisfz1m	84	31	is	be	VBZ
cord-306948-wkisfz1m	84	32	introduced	introduce	VBN
cord-306948-wkisfz1m	84	33	to	to	IN
cord-306948-wkisfz1m	84	34	cells	cell	NNS
cord-306948-wkisfz1m	84	35	for	for	IN
cord-306948-wkisfz1m	84	36	transcription	transcription	NN
cord-306948-wkisfz1m	84	37	by	by	IN
cord-306948-wkisfz1m	84	38	exploiting	exploit	VBG
cord-306948-wkisfz1m	84	39	the	the	DT
cord-306948-wkisfz1m	84	40	nuclear	nuclear	JJ
cord-306948-wkisfz1m	84	41	function	function	NN
cord-306948-wkisfz1m	84	42	of	of	IN
cord-306948-wkisfz1m	84	43	the	the	DT
cord-306948-wkisfz1m	84	44	cell	cell	NN
cord-306948-wkisfz1m	84	45	.	.	.
cord-306948-wkisfz1m	85	1	The	the	DT
cord-306948-wkisfz1m	85	2	transcribed	transcribe	VBN
cord-306948-wkisfz1m	85	3	viral	viral	JJ
cord-306948-wkisfz1m	85	4	genome	genome	NN
cord-306948-wkisfz1m	85	5	in	in	IN
cord-306948-wkisfz1m	85	6	the	the	DT
cord-306948-wkisfz1m	85	7	nucleus	nucleus	NN
cord-306948-wkisfz1m	85	8	is	be	VBZ
cord-306948-wkisfz1m	85	9	exported	export	VBN
cord-306948-wkisfz1m	85	10	to	to	IN
cord-306948-wkisfz1m	85	11	the	the	DT
cord-306948-wkisfz1m	85	12	cytoplasm	cytoplasm	NN
cord-306948-wkisfz1m	85	13	where	where	WRB
cord-306948-wkisfz1m	85	14	viral	viral	JJ
cord-306948-wkisfz1m	85	15	genome	genome	NN
cord-306948-wkisfz1m	85	16	translation	translation	NN
cord-306948-wkisfz1m	85	17	and	and	CC
cord-306948-wkisfz1m	85	18	replication	replication	NN
cord-306948-wkisfz1m	85	19	occur	occur	VBP
cord-306948-wkisfz1m	85	20	.	.	.
cord-306948-wkisfz1m	86	1	This	this	DT
cord-306948-wkisfz1m	86	2	strategy	strategy	NN
cord-306948-wkisfz1m	86	3	omits	omit	VBZ
cord-306948-wkisfz1m	86	4	the	the	DT
cord-306948-wkisfz1m	86	5	steps	step	NNS
cord-306948-wkisfz1m	86	6	of	of	IN
cord-306948-wkisfz1m	86	7	in	in	FW
cord-306948-wkisfz1m	86	8	vitro	vitro	FW
cord-306948-wkisfz1m	86	9	synthesis	synthesis	NN
cord-306948-wkisfz1m	86	10	of	of	IN
cord-306948-wkisfz1m	86	11	genomic	genomic	NNP
cord-306948-wkisfz1m	86	12	RNA	RNA	NNP
cord-306948-wkisfz1m	86	13	and	and	CC
cord-306948-wkisfz1m	86	14	RNA	RNA	NNP
cord-306948-wkisfz1m	86	15	transfection	transfection	NN
cord-306948-wkisfz1m	86	16	,	,	,
cord-306948-wkisfz1m	86	17	thus	thus	RB
cord-306948-wkisfz1m	86	18	the	the	DT
cord-306948-wkisfz1m	86	19	risk	risk	NN
cord-306948-wkisfz1m	86	20	of	of	IN
cord-306948-wkisfz1m	86	21	RNA	RNA	NNP
cord-306948-wkisfz1m	86	22	degradation	degradation	NN
cord-306948-wkisfz1m	86	23	during	during	IN
cord-306948-wkisfz1m	86	24	transfection	transfection	NN
cord-306948-wkisfz1m	86	25	is	be	VBZ
cord-306948-wkisfz1m	86	26	reduced	reduce	VBN
cord-306948-wkisfz1m	86	27	and	and	CC
cord-306948-wkisfz1m	86	28	transfection	transfection	NN
cord-306948-wkisfz1m	86	29	efficiency	efficiency	NN
cord-306948-wkisfz1m	86	30	becomes	become	VBZ
cord-306948-wkisfz1m	86	31	consistent	consistent	JJ
cord-306948-wkisfz1m	86	32	)	)	-RRB-
cord-306948-wkisfz1m	86	33	.	.	.
cord-306948-wkisfz1m	87	1	An	an	DT
cord-306948-wkisfz1m	87	2	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	87	3	infectious	infectious	JJ
cord-306948-wkisfz1m	87	4	clone	clone	NN
cord-306948-wkisfz1m	87	5	was	be	VBD
cord-306948-wkisfz1m	87	6	first	first	RB
cord-306948-wkisfz1m	87	7	made	make	VBN
cord-306948-wkisfz1m	87	8	for	for	IN
cord-306948-wkisfz1m	87	9	EAV	EAV	NNP
cord-306948-wkisfz1m	87	10	.	.	.
cord-306948-wkisfz1m	88	1	The	the	DT
cord-306948-wkisfz1m	88	2	pEAV030	pEAV030	NNP
cord-306948-wkisfz1m	88	3	full	full	JJ
cord-306948-wkisfz1m	88	4	-	-	HYPH
cord-306948-wkisfz1m	88	5	length	length	NN
cord-306948-wkisfz1m	88	6	clone	clone	NN
cord-306948-wkisfz1m	88	7	containing	contain	VBG
cord-306948-wkisfz1m	88	8	the	the	DT
cord-306948-wkisfz1m	88	9	12.7	12.7	CD
cord-306948-wkisfz1m	88	10	kb	kb	NNP
cord-306948-wkisfz1m	88	11	cDNA	cDNA	NNP
cord-306948-wkisfz1m	88	12	copy	copy	NN
cord-306948-wkisfz1m	88	13	of	of	IN
cord-306948-wkisfz1m	88	14	the	the	DT
cord-306948-wkisfz1m	88	15	EAV	EAV	NNP
cord-306948-wkisfz1m	88	16	genome	genome	NN
cord-306948-wkisfz1m	88	17	was	be	VBD
cord-306948-wkisfz1m	88	18	infectious	infectious	JJ
cord-306948-wkisfz1m	89	1	(	(	-LRB-
cord-306948-wkisfz1m	89	2	van	van	NNP
cord-306948-wkisfz1m	89	3	Dinten	Dinten	NNP
cord-306948-wkisfz1m	89	4	et	et	FW
cord-306948-wkisfz1m	89	5	al	al	NNP
cord-306948-wkisfz1m	89	6	.	.	NNP
cord-306948-wkisfz1m	89	7	,	,	,
cord-306948-wkisfz1m	89	8	1997	1997	CD
cord-306948-wkisfz1m	89	9	)	)	-RRB-
cord-306948-wkisfz1m	89	10	,	,	,
cord-306948-wkisfz1m	89	11	and	and	CC
cord-306948-wkisfz1m	89	12	the	the	DT
cord-306948-wkisfz1m	89	13	first	first	JJ
cord-306948-wkisfz1m	89	14	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	89	15	infectious	infectious	JJ
cord-306948-wkisfz1m	89	16	clone	clone	NN
cord-306948-wkisfz1m	89	17	pABV437	pABV437	NNP
cord-306948-wkisfz1m	89	18	was	be	VBD
cord-306948-wkisfz1m	89	19	developed	develop	VBN
cord-306948-wkisfz1m	89	20	for	for	IN
cord-306948-wkisfz1m	89	21	the	the	DT
cord-306948-wkisfz1m	89	22	genotype	genotype	NN
cord-306948-wkisfz1m	89	23	I	-PRON-	PRP
cord-306948-wkisfz1m	89	24	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	89	25	Lelystad	Lelystad	NNP
cord-306948-wkisfz1m	89	26	virus	virus	NN
cord-306948-wkisfz1m	89	27	.	.	.
cord-306948-wkisfz1m	90	1	Subsequently	subsequently	RB
cord-306948-wkisfz1m	90	2	,	,	,
cord-306948-wkisfz1m	90	3	infectious	infectious	JJ
cord-306948-wkisfz1m	90	4	clones	clone	NNS
cord-306948-wkisfz1m	90	5	for	for	IN
cord-306948-wkisfz1m	90	6	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	90	7	which	which	WDT
cord-306948-wkisfz1m	90	8	is	be	VBZ
cord-306948-wkisfz1m	90	9	the	the	DT
cord-306948-wkisfz1m	90	10	genotype	genotype	NN
cord-306948-wkisfz1m	90	11	II	II	NNP
cord-306948-wkisfz1m	90	12	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	90	13	,	,	,
cord-306948-wkisfz1m	90	14	and	and	CC
cord-306948-wkisfz1m	90	15	the	the	DT
cord-306948-wkisfz1m	90	16	European	european	JJ
cord-306948-wkisfz1m	90	17	-	-	HYPH
cord-306948-wkisfz1m	90	18	like	like	JJ
cord-306948-wkisfz1m	90	19	genotype	genotype	NN
cord-306948-wkisfz1m	90	20	I	-PRON-	PRP
cord-306948-wkisfz1m	90	21	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	90	22	SD01	SD01	NNP
cord-306948-wkisfz1m	90	23	-	-	HYPH
cord-306948-wkisfz1m	90	24	08	08	CD
cord-306948-wkisfz1m	90	25	circulating	circulate	VBG
cord-306948-wkisfz1m	90	26	in	in	IN
cord-306948-wkisfz1m	90	27	the	the	DT
cord-306948-wkisfz1m	90	28	US	US	NNP
cord-306948-wkisfz1m	90	29	was	be	VBD
cord-306948-wkisfz1m	90	30	developed	develop	VBN
cord-306948-wkisfz1m	90	31	(	(	-LRB-
cord-306948-wkisfz1m	90	32	Fang	Fang	NNP
cord-306948-wkisfz1m	90	33	et	et	FW
cord-306948-wkisfz1m	90	34	al	al	NNP
cord-306948-wkisfz1m	90	35	.	.	.
cord-306948-wkisfz1m	91	1	,	,	,
cord-306948-wkisfz1m	91	2	2006a	2006a	CD
cord-306948-wkisfz1m	92	1	(	(	-LRB-
cord-306948-wkisfz1m	92	2	Fang	Fang	NNP
cord-306948-wkisfz1m	92	3	et	et	FW
cord-306948-wkisfz1m	92	4	al	al	NNP
cord-306948-wkisfz1m	92	5	.	.	.
cord-306948-wkisfz1m	93	1	,	,	,
cord-306948-wkisfz1m	93	2	,	,	,
cord-306948-wkisfz1m	93	3	2006b	2006b	CD
cord-306948-wkisfz1m	93	4	Nielsen	Nielsen	NNP
cord-306948-wkisfz1m	93	5	et	et	NNP
cord-306948-wkisfz1m	93	6	al	al	NNP
cord-306948-wkisfz1m	93	7	.	.	NNP
cord-306948-wkisfz1m	93	8	,	,	,
cord-306948-wkisfz1m	93	9	2003	2003	CD
cord-306948-wkisfz1m	93	10	)	)	-RRB-
cord-306948-wkisfz1m	93	11	.	.	.
cord-306948-wkisfz1m	94	1	Numerous	numerous	JJ
cord-306948-wkisfz1m	94	2	clones	clone	NNS
cord-306948-wkisfz1m	94	3	have	have	VBP
cord-306948-wkisfz1m	94	4	additionally	additionally	RB
cord-306948-wkisfz1m	94	5	been	be	VBN
cord-306948-wkisfz1m	94	6	developed	develop	VBN
cord-306948-wkisfz1m	94	7	including	include	VBG
cord-306948-wkisfz1m	94	8	the	the	DT
cord-306948-wkisfz1m	94	9	highly	highly	RB
cord-306948-wkisfz1m	94	10	-	-	HYPH
cord-306948-wkisfz1m	94	11	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	94	12	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	94	13	that	that	WDT
cord-306948-wkisfz1m	94	14	emerged	emerge	VBD
cord-306948-wkisfz1m	94	15	in	in	IN
cord-306948-wkisfz1m	94	16	China	China	NNP
cord-306948-wkisfz1m	94	17	in	in	IN
cord-306948-wkisfz1m	94	18	2006	2006	CD
cord-306948-wkisfz1m	95	1	(	(	-LRB-
cord-306948-wkisfz1m	95	2	Guo	Guo	NNP
cord-306948-wkisfz1m	95	3	et	et	FW
cord-306948-wkisfz1m	95	4	al	al	NNP
cord-306948-wkisfz1m	95	5	.	.	NNP
cord-306948-wkisfz1m	95	6	,	,	,
cord-306948-wkisfz1m	95	7	2013	2013	CD
cord-306948-wkisfz1m	95	8	;	;	:
cord-306948-wkisfz1m	95	9	Lv	Lv	NNP
cord-306948-wkisfz1m	95	10	et	et	NNP
cord-306948-wkisfz1m	95	11	al	al	NNP
cord-306948-wkisfz1m	95	12	.	.	NNP
cord-306948-wkisfz1m	95	13	,	,	,
cord-306948-wkisfz1m	95	14	2008	2008	CD
cord-306948-wkisfz1m	96	1	;	;	:
cord-306948-wkisfz1m	96	2	Zhou	Zhou	NNP
cord-306948-wkisfz1m	96	3	et	et	NNP
cord-306948-wkisfz1m	96	4	al	al	NNP
cord-306948-wkisfz1m	96	5	.	.	NNP
cord-306948-wkisfz1m	96	6	,	,	,
cord-306948-wkisfz1m	96	7	2009	2009	CD
cord-306948-wkisfz1m	96	8	)	)	-RRB-
cord-306948-wkisfz1m	96	9	.	.	.
cord-306948-wkisfz1m	97	1	To	to	IN
cord-306948-wkisfz1m	97	2	date	date	NN
cord-306948-wkisfz1m	97	3	,	,	,
cord-306948-wkisfz1m	97	4	at	at	IN
cord-306948-wkisfz1m	97	5	least	least	RBS
cord-306948-wkisfz1m	97	6	14	14	CD
cord-306948-wkisfz1m	97	7	different	different	JJ
cord-306948-wkisfz1m	97	8	infectious	infectious	JJ
cord-306948-wkisfz1m	97	9	clones	clone	NNS
cord-306948-wkisfz1m	97	10	are	be	VBP
cord-306948-wkisfz1m	97	11	available	available	JJ
cord-306948-wkisfz1m	97	12	for	for	IN
cord-306948-wkisfz1m	97	13	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	97	14	(	(	-LRB-
cord-306948-wkisfz1m	97	15	Table	Table	NNP
cord-306948-wkisfz1m	97	16	1	1	CD
cord-306948-wkisfz1m	97	17	)	)	-RRB-
cord-306948-wkisfz1m	97	18	.	.	.
cord-306948-wkisfz1m	98	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	98	2	infectious	infectious	JJ
cord-306948-wkisfz1m	98	3	clones	clone	NNS
cord-306948-wkisfz1m	98	4	have	have	VBP
cord-306948-wkisfz1m	98	5	mostly	mostly	RB
cord-306948-wkisfz1m	98	6	been	be	VBN
cord-306948-wkisfz1m	98	7	developed	develop	VBN
cord-306948-wkisfz1m	98	8	based	base	VBN
cord-306948-wkisfz1m	98	9	on	on	IN
cord-306948-wkisfz1m	98	10	the	the	DT
cord-306948-wkisfz1m	98	11	RNA	RNA	NNP
cord-306948-wkisfz1m	98	12	launch	launch	NN
cord-306948-wkisfz1m	98	13	strategy	strategy	NN
cord-306948-wkisfz1m	98	14	.	.	.
cord-306948-wkisfz1m	99	1	BHK-21	BHK-21	NNP
cord-306948-wkisfz1m	99	2	,	,	,
cord-306948-wkisfz1m	99	3	MA-104	ma-104	NN
cord-306948-wkisfz1m	99	4	,	,	,
cord-306948-wkisfz1m	100	1	and	and	CC
cord-306948-wkisfz1m	100	2	MARC-145	MARC-145	NNP
cord-306948-wkisfz1m	100	3	cells	cell	NNS
cord-306948-wkisfz1m	100	4	are	be	VBP
cord-306948-wkisfz1m	100	5	cells	cell	NNS
cord-306948-wkisfz1m	100	6	of	of	IN
cord-306948-wkisfz1m	100	7	choice	choice	NN
cord-306948-wkisfz1m	100	8	for	for	IN
cord-306948-wkisfz1m	100	9	transfection	transfection	NN
cord-306948-wkisfz1m	100	10	and	and	CC
cord-306948-wkisfz1m	100	11	progeny	progeny	NN
cord-306948-wkisfz1m	100	12	production	production	NN
cord-306948-wkisfz1m	100	13	.	.	.
cord-306948-wkisfz1m	101	1	Although	although	IN
cord-306948-wkisfz1m	101	2	BHK-21	BHK-21	NNP
cord-306948-wkisfz1m	101	3	cells	cell	NNS
cord-306948-wkisfz1m	101	4	are	be	VBP
cord-306948-wkisfz1m	101	5	nonpermissive	nonpermissive	JJ
cord-306948-wkisfz1m	101	6	for	for	IN
cord-306948-wkisfz1m	101	7	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	101	8	infection	infection	NN
cord-306948-wkisfz1m	101	9	,	,	,
cord-306948-wkisfz1m	101	10	they	-PRON-	PRP
cord-306948-wkisfz1m	101	11	provide	provide	VBP
cord-306948-wkisfz1m	101	12	a	a	DT
cord-306948-wkisfz1m	101	13	high	high	JJ
cord-306948-wkisfz1m	101	14	efficiency	efficiency	NN
cord-306948-wkisfz1m	101	15	of	of	IN
cord-306948-wkisfz1m	101	16	transfection	transfection	NN
cord-306948-wkisfz1m	101	17	and	and	CC
cord-306948-wkisfz1m	101	18	a	a	DT
cord-306948-wkisfz1m	101	19	good	good	JJ
cord-306948-wkisfz1m	101	20	production	production	NN
cord-306948-wkisfz1m	101	21	of	of	IN
cord-306948-wkisfz1m	101	22	progeny	progeny	NN
cord-306948-wkisfz1m	101	23	.	.	.
cord-306948-wkisfz1m	102	1	To	to	TO
cord-306948-wkisfz1m	102	2	eliminate	eliminate	VB
cord-306948-wkisfz1m	102	3	the	the	DT
cord-306948-wkisfz1m	102	4	need	need	NN
cord-306948-wkisfz1m	102	5	for	for	IN
cord-306948-wkisfz1m	102	6	in	in	FW
cord-306948-wkisfz1m	102	7	vitro	vitro	FW
cord-306948-wkisfz1m	102	8	transcription	transcription	NN
cord-306948-wkisfz1m	102	9	and	and	CC
cord-306948-wkisfz1m	102	10	consistency	consistency	NN
cord-306948-wkisfz1m	102	11	associated	associate	VBN
cord-306948-wkisfz1m	102	12	with	with	IN
cord-306948-wkisfz1m	102	13	RNA	RNA	NNP
cord-306948-wkisfz1m	102	14	transfection	transfection	NN
cord-306948-wkisfz1m	102	15	,	,	,
cord-306948-wkisfz1m	102	16	the	the	DT
cord-306948-wkisfz1m	102	17	CMV	CMV	NNP
cord-306948-wkisfz1m	102	18	promoter	promoter	NN
cord-306948-wkisfz1m	102	19	has	have	VBZ
cord-306948-wkisfz1m	102	20	been	be	VBN
cord-306948-wkisfz1m	102	21	used	use	VBN
cord-306948-wkisfz1m	102	22	for	for	IN
cord-306948-wkisfz1m	102	23	construction	construction	NN
cord-306948-wkisfz1m	102	24	of	of	IN
cord-306948-wkisfz1m	102	25	the	the	DT
cord-306948-wkisfz1m	102	26	P129	P129	NNPS
cord-306948-wkisfz1m	102	27	infectious	infectious	JJ
cord-306948-wkisfz1m	102	28	clone	clone	NN
cord-306948-wkisfz1m	102	29	.	.	.
cord-306948-wkisfz1m	103	1	The	the	DT
cord-306948-wkisfz1m	103	2	P129	P129	NNPS
cord-306948-wkisfz1m	103	3	virus	virus	NN
cord-306948-wkisfz1m	103	4	is	be	VBZ
cord-306948-wkisfz1m	103	5	an	an	DT
cord-306948-wkisfz1m	103	6	isolate	isolate	NN
cord-306948-wkisfz1m	103	7	recovered	recover	VBN
cord-306948-wkisfz1m	103	8	from	from	IN
cord-306948-wkisfz1m	103	9	an	an	DT
cord-306948-wkisfz1m	103	10	outbreak	outbreak	NN
cord-306948-wkisfz1m	103	11	of	of	IN
cord-306948-wkisfz1m	103	12	highly	highly	RB
cord-306948-wkisfz1m	103	13	virulent	virulent	JJ
cord-306948-wkisfz1m	103	14	atypical	atypical	JJ
cord-306948-wkisfz1m	103	15	PRRS	PRRS	NNP
cord-306948-wkisfz1m	103	16	in	in	IN
cord-306948-wkisfz1m	103	17	the	the	DT
cord-306948-wkisfz1m	103	18	mid	mid	JJ
cord-306948-wkisfz1m	103	19	-	-	JJ
cord-306948-wkisfz1m	103	20	Western	western	JJ
cord-306948-wkisfz1m	103	21	USA	USA	NNP
cord-306948-wkisfz1m	103	22	in	in	IN
cord-306948-wkisfz1m	103	23	1995	1995	CD
cord-306948-wkisfz1m	104	1	Yoo	Yoo	NNP
cord-306948-wkisfz1m	104	2	et	et	NNP
cord-306948-wkisfz1m	104	3	al	al	NNP
cord-306948-wkisfz1m	104	4	.	.	NNP
cord-306948-wkisfz1m	104	5	,	,	,
cord-306948-wkisfz1m	104	6	2004	2004	CD
cord-306948-wkisfz1m	104	7	)	)	-RRB-
cord-306948-wkisfz1m	104	8	.	.	.
cord-306948-wkisfz1m	105	1	The	the	DT
cord-306948-wkisfz1m	105	2	CMV	CMV	NNP
cord-306948-wkisfz1m	105	3	promoter	promoter	NN
cord-306948-wkisfz1m	105	4	-	-	HYPH
cord-306948-wkisfz1m	105	5	based	base	VBN
cord-306948-wkisfz1m	105	6	infectious	infectious	JJ
cord-306948-wkisfz1m	105	7	clone	clone	NN
cord-306948-wkisfz1m	105	8	is	be	VBZ
cord-306948-wkisfz1m	105	9	convenient	convenient	JJ
cord-306948-wkisfz1m	105	10	and	and	CC
cord-306948-wkisfz1m	105	11	simple	simple	JJ
cord-306948-wkisfz1m	105	12	to	to	TO
cord-306948-wkisfz1m	105	13	use	use	VB
cord-306948-wkisfz1m	105	14	and	and	CC
cord-306948-wkisfz1m	105	15	provides	provide	VBZ
cord-306948-wkisfz1m	105	16	a	a	DT
cord-306948-wkisfz1m	105	17	consistency	consistency	NN
cord-306948-wkisfz1m	105	18	of	of	IN
cord-306948-wkisfz1m	105	19	transfection	transfection	NN
cord-306948-wkisfz1m	105	20	and	and	CC
cord-306948-wkisfz1m	105	21	recovery	recovery	NN
cord-306948-wkisfz1m	105	22	of	of	IN
cord-306948-wkisfz1m	105	23	progeny	progeny	JJ
cord-306948-wkisfz1m	105	24	virus	virus	NN
cord-306948-wkisfz1m	105	25	)	)	-RRB-
cord-306948-wkisfz1m	105	26	.	.	.
cord-306948-wkisfz1m	106	1	An	an	DT
cord-306948-wkisfz1m	106	2	infectious	infectious	JJ
cord-306948-wkisfz1m	106	3	clone	clone	NN
cord-306948-wkisfz1m	106	4	should	should	MD
cord-306948-wkisfz1m	106	5	genetically	genetically	RB
cord-306948-wkisfz1m	106	6	be	be	VB
cord-306948-wkisfz1m	106	7	identical	identical	JJ
cord-306948-wkisfz1m	106	8	to	to	IN
cord-306948-wkisfz1m	106	9	the	the	DT
cord-306948-wkisfz1m	106	10	parental	parental	JJ
cord-306948-wkisfz1m	106	11	virus	virus	NN
cord-306948-wkisfz1m	106	12	.	.	.
cord-306948-wkisfz1m	107	1	However	however	RB
cord-306948-wkisfz1m	107	2	,	,	,
cord-306948-wkisfz1m	107	3	non	non	JJ
cord-306948-wkisfz1m	107	4	-	-	JJ
cord-306948-wkisfz1m	107	5	viral	viral	JJ
cord-306948-wkisfz1m	107	6	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	107	7	are	be	VBP
cord-306948-wkisfz1m	107	8	occasionally	occasionally	RB
cord-306948-wkisfz1m	107	9	added	add	VBN
cord-306948-wkisfz1m	107	10	to	to	IN
cord-306948-wkisfz1m	107	11	the	the	DT
cord-306948-wkisfz1m	107	12	viral	viral	JJ
cord-306948-wkisfz1m	107	13	genome	genome	NN
cord-306948-wkisfz1m	107	14	at	at	IN
cord-306948-wkisfz1m	107	15	the	the	DT
cord-306948-wkisfz1m	107	16	5	5	CD
cord-306948-wkisfz1m	107	17	0	0	CD
cord-306948-wkisfz1m	107	18	or	or	CC
cord-306948-wkisfz1m	107	19	3	3	CD
cord-306948-wkisfz1m	107	20	0	0	CD
cord-306948-wkisfz1m	107	21	end	end	NN
cord-306948-wkisfz1m	107	22	to	to	TO
cord-306948-wkisfz1m	107	23	meet	meet	VB
cord-306948-wkisfz1m	107	24	the	the	DT
cord-306948-wkisfz1m	107	25	engineering	engineering	NN
cord-306948-wkisfz1m	107	26	needs	need	NNS
cord-306948-wkisfz1m	107	27	without	without	IN
cord-306948-wkisfz1m	107	28	impeding	impede	VBG
cord-306948-wkisfz1m	107	29	the	the	DT
cord-306948-wkisfz1m	107	30	infectivity	infectivity	NN
cord-306948-wkisfz1m	107	31	of	of	IN
cord-306948-wkisfz1m	107	32	the	the	DT
cord-306948-wkisfz1m	107	33	clones	clone	NNS
cord-306948-wkisfz1m	107	34	Truong	Truong	NNP
cord-306948-wkisfz1m	107	35	et	et	NNP
cord-306948-wkisfz1m	107	36	al	al	NNP
cord-306948-wkisfz1m	107	37	.	.	NNP
cord-306948-wkisfz1m	107	38	,	,	,
cord-306948-wkisfz1m	107	39	2004	2004	CD
cord-306948-wkisfz1m	107	40	)	)	-RRB-
cord-306948-wkisfz1m	107	41	.	.	.
cord-306948-wkisfz1m	108	1	To	to	TO
cord-306948-wkisfz1m	108	2	differentiate	differentiate	VB
cord-306948-wkisfz1m	108	3	the	the	DT
cord-306948-wkisfz1m	108	4	reconstituted	reconstitute	VBN
cord-306948-wkisfz1m	108	5	progeny	progeny	JJ
cord-306948-wkisfz1m	108	6	virus	virus	NN
cord-306948-wkisfz1m	108	7	from	from	IN
cord-306948-wkisfz1m	108	8	the	the	DT
cord-306948-wkisfz1m	108	9	parental	parental	JJ
cord-306948-wkisfz1m	108	10	virus	virus	NN
cord-306948-wkisfz1m	108	11	,	,	,
cord-306948-wkisfz1m	108	12	genetic	genetic	JJ
cord-306948-wkisfz1m	108	13	markers	marker	NNS
cord-306948-wkisfz1m	108	14	of	of	IN
cord-306948-wkisfz1m	108	15	either	either	DT
cord-306948-wkisfz1m	108	16	restricted	restricted	JJ
cord-306948-wkisfz1m	108	17	enzyme	enzyme	NN
cord-306948-wkisfz1m	108	18	recognition	recognition	NN
cord-306948-wkisfz1m	108	19	sequences	sequence	NNS
cord-306948-wkisfz1m	108	20	or	or	CC
cord-306948-wkisfz1m	108	21	certain	certain	JJ
cord-306948-wkisfz1m	108	22	nucleotide	nucleotide	JJ
cord-306948-wkisfz1m	108	23	mutations	mutation	NNS
cord-306948-wkisfz1m	108	24	have	have	VBP
cord-306948-wkisfz1m	108	25	been	be	VBN
cord-306948-wkisfz1m	108	26	introduced	introduce	VBN
cord-306948-wkisfz1m	108	27	to	to	IN
cord-306948-wkisfz1m	108	28	infectious	infectious	JJ
cord-306948-wkisfz1m	108	29	clones	clone	NNS
cord-306948-wkisfz1m	108	30	,	,	,
cord-306948-wkisfz1m	108	31	and	and	CC
cord-306948-wkisfz1m	108	32	such	such	JJ
cord-306948-wkisfz1m	108	33	modifications	modification	NNS
cord-306948-wkisfz1m	108	34	should	should	MD
cord-306948-wkisfz1m	108	35	be	be	VB
cord-306948-wkisfz1m	108	36	non	non	JJ
cord-306948-wkisfz1m	108	37	-	-	JJ
cord-306948-wkisfz1m	108	38	lethal	lethal	JJ
cord-306948-wkisfz1m	108	39	and	and	CC
cord-306948-wkisfz1m	108	40	stable	stable	JJ
cord-306948-wkisfz1m	108	41	.	.	.
cord-306948-wkisfz1m	109	1	To	to	TO
cord-306948-wkisfz1m	109	2	assure	assure	VB
cord-306948-wkisfz1m	109	3	the	the	DT
cord-306948-wkisfz1m	109	4	starting	starting	NN
cord-306948-wkisfz1m	109	5	position	position	NN
cord-306948-wkisfz1m	109	6	of	of	IN
cord-306948-wkisfz1m	109	7	the	the	DT
cord-306948-wkisfz1m	109	8	RNA	RNA	NNP
cord-306948-wkisfz1m	109	9	polymerase	polymerase	NN
cord-306948-wkisfz1m	109	10	II	II	NNP
cord-306948-wkisfz1m	109	11	-	-	HYPH
cord-306948-wkisfz1m	109	12	mediated	mediate	VBN
cord-306948-wkisfz1m	109	13	transcription	transcription	NN
cord-306948-wkisfz1m	109	14	,	,	,
cord-306948-wkisfz1m	109	15	24	24	CD
cord-306948-wkisfz1m	109	16	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	109	17	are	be	VBP
cord-306948-wkisfz1m	109	18	placed	place	VBN
cord-306948-wkisfz1m	109	19	between	between	IN
cord-306948-wkisfz1m	109	20	the	the	DT
cord-306948-wkisfz1m	109	21	TATA	TATA	NNP
cord-306948-wkisfz1m	109	22	box	box	NN
cord-306948-wkisfz1m	109	23	and	and	CC
cord-306948-wkisfz1m	109	24	the	the	DT
cord-306948-wkisfz1m	109	25	genome	genome	NN
cord-306948-wkisfz1m	109	26	start	start	NN
cord-306948-wkisfz1m	109	27	when	when	WRB
cord-306948-wkisfz1m	109	28	constructing	construct	VBG
cord-306948-wkisfz1m	109	29	pCMV	pcmv	NN
cord-306948-wkisfz1m	109	30	-	-	HYPH
cord-306948-wkisfz1m	109	31	S	s	NN
cord-306948-wkisfz1m	109	32	-	-	HYPH
cord-306948-wkisfz1m	109	33	P129	P129	NNPS
cord-306948-wkisfz1m	109	34	.	.	.
cord-306948-wkisfz1m	110	1	The	the	DT
cord-306948-wkisfz1m	110	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	110	3	genome	genome	NN
cord-306948-wkisfz1m	110	4	is	be	VBZ
cord-306948-wkisfz1m	110	5	usually	usually	RB
cord-306948-wkisfz1m	110	6	divided	divide	VBN
cord-306948-wkisfz1m	110	7	to	to	IN
cord-306948-wkisfz1m	110	8	several	several	JJ
cord-306948-wkisfz1m	110	9	fragments	fragment	NNS
cord-306948-wkisfz1m	110	10	flanked	flank	VBN
cord-306948-wkisfz1m	110	11	by	by	IN
cord-306948-wkisfz1m	110	12	restriction	restriction	NN
cord-306948-wkisfz1m	110	13	sites	site	NNS
cord-306948-wkisfz1m	110	14	for	for	IN
cord-306948-wkisfz1m	110	15	subsequent	subsequent	JJ
cord-306948-wkisfz1m	110	16	assembly	assembly	NN
cord-306948-wkisfz1m	110	17	Nielsen	Nielsen	NNP
cord-306948-wkisfz1m	110	18	et	et	NNP
cord-306948-wkisfz1m	110	19	al	al	NNP
cord-306948-wkisfz1m	110	20	.	.	NNP
cord-306948-wkisfz1m	110	21	,	,	,
cord-306948-wkisfz1m	110	22	2003	2003	CD
cord-306948-wkisfz1m	110	23	)	)	-RRB-
cord-306948-wkisfz1m	110	24	.	.	.
cord-306948-wkisfz1m	111	1	As	as	IN
cord-306948-wkisfz1m	111	2	a	a	DT
cord-306948-wkisfz1m	111	3	cloning	cloning	NN
cord-306948-wkisfz1m	111	4	vector	vector	NN
cord-306948-wkisfz1m	111	5	,	,	,
cord-306948-wkisfz1m	111	6	a	a	DT
cord-306948-wkisfz1m	111	7	lowcopy	lowcopy	NN
cord-306948-wkisfz1m	111	8	-	-	HYPH
cord-306948-wkisfz1m	111	9	number	number	NN
cord-306948-wkisfz1m	111	10	plasmid	plasmid	NN
cord-306948-wkisfz1m	111	11	is	be	VBZ
cord-306948-wkisfz1m	111	12	generally	generally	RB
cord-306948-wkisfz1m	111	13	preferred	prefer	VBN
cord-306948-wkisfz1m	111	14	as	as	IN
cord-306948-wkisfz1m	111	15	suggested	suggest	VBN
cord-306948-wkisfz1m	111	16	in	in	IN
cord-306948-wkisfz1m	111	17	some	some	DT
cord-306948-wkisfz1m	111	18	studies	study	NNS
cord-306948-wkisfz1m	111	19	Sumiyoshi	Sumiyoshi	NNP
cord-306948-wkisfz1m	111	20	et	et	NNP
cord-306948-wkisfz1m	111	21	al	al	NNP
cord-306948-wkisfz1m	111	22	.	.	NNP
cord-306948-wkisfz1m	111	23	,	,	,
cord-306948-wkisfz1m	111	24	1992	1992	CD
cord-306948-wkisfz1m	111	25	;	;	:
cord-306948-wkisfz1m	111	26	Nielsen	Nielsen	NNP
cord-306948-wkisfz1m	111	27	et	et	NNP
cord-306948-wkisfz1m	111	28	al	al	NNP
cord-306948-wkisfz1m	111	29	.	.	NNP
cord-306948-wkisfz1m	111	30	,	,	,
cord-306948-wkisfz1m	111	31	2003	2003	CD
cord-306948-wkisfz1m	111	32	)	)	-RRB-
cord-306948-wkisfz1m	111	33	but	but	CC
cord-306948-wkisfz1m	111	34	has	have	VBZ
cord-306948-wkisfz1m	111	35	appeared	appear	VBN
cord-306948-wkisfz1m	111	36	unnecessary	unnecessary	JJ
cord-306948-wkisfz1m	111	37	.	.	.
cord-306948-wkisfz1m	112	1	Progeny	progeny	JJ
cord-306948-wkisfz1m	112	2	virus	virus	NN
cord-306948-wkisfz1m	112	3	generated	generate	VBN
cord-306948-wkisfz1m	112	4	from	from	IN
cord-306948-wkisfz1m	112	5	an	an	DT
cord-306948-wkisfz1m	112	6	infectious	infectious	JJ
cord-306948-wkisfz1m	112	7	clone	clone	NN
cord-306948-wkisfz1m	112	8	should	should	MD
cord-306948-wkisfz1m	112	9	ideally	ideally	RB
cord-306948-wkisfz1m	112	10	retain	retain	VB
cord-306948-wkisfz1m	112	11	the	the	DT
cord-306948-wkisfz1m	112	12	biological	biological	JJ
cord-306948-wkisfz1m	112	13	properties	property	NNS
cord-306948-wkisfz1m	112	14	of	of	IN
cord-306948-wkisfz1m	112	15	the	the	DT
cord-306948-wkisfz1m	112	16	parental	parental	JJ
cord-306948-wkisfz1m	112	17	virus	virus	NN
cord-306948-wkisfz1m	112	18	,	,	,
cord-306948-wkisfz1m	112	19	such	such	JJ
cord-306948-wkisfz1m	112	20	as	as	IN
cord-306948-wkisfz1m	112	21	growth	growth	NN
cord-306948-wkisfz1m	112	22	rate	rate	NN
cord-306948-wkisfz1m	112	23	,	,	,
cord-306948-wkisfz1m	112	24	virulence	virulence	NN
cord-306948-wkisfz1m	112	25	,	,	,
cord-306948-wkisfz1m	112	26	and	and	CC
cord-306948-wkisfz1m	112	27	transmissibility	transmissibility	NN
cord-306948-wkisfz1m	112	28	Meulenberg	Meulenberg	NNP
cord-306948-wkisfz1m	112	29	et	et	NNP
cord-306948-wkisfz1m	112	30	al	al	NNP
cord-306948-wkisfz1m	112	31	.	.	NNP
cord-306948-wkisfz1m	112	32	,	,	,
cord-306948-wkisfz1m	112	33	1998	1998	CD
cord-306948-wkisfz1m	112	34	;	;	:
cord-306948-wkisfz1m	112	35	Nielsen	Nielsen	NNP
cord-306948-wkisfz1m	112	36	et	et	NNP
cord-306948-wkisfz1m	112	37	al	al	NNP
cord-306948-wkisfz1m	112	38	.	.	.
cord-306948-wkisfz1m	113	1	,	,	,
cord-306948-wkisfz1m	113	2	2003	2003	CD
cord-306948-wkisfz1m	113	3	;	;	:
cord-306948-wkisfz1m	113	4	Truong	Truong	NNP
cord-306948-wkisfz1m	113	5	et	et	NNP
cord-306948-wkisfz1m	113	6	al	al	NNP
cord-306948-wkisfz1m	113	7	.	.	NNP
cord-306948-wkisfz1m	113	8	,	,	,
cord-306948-wkisfz1m	113	9	2004	2004	CD
cord-306948-wkisfz1m	113	10	;	;	:
cord-306948-wkisfz1m	113	11	Yuan	Yuan	NNP
cord-306948-wkisfz1m	113	12	and	and	CC
cord-306948-wkisfz1m	113	13	Wei	Wei	NNP
cord-306948-wkisfz1m	113	14	,	,	,
cord-306948-wkisfz1m	113	15	2008	2008	CD
cord-306948-wkisfz1m	113	16	)	)	-RRB-
cord-306948-wkisfz1m	113	17	.	.	.
cord-306948-wkisfz1m	114	1	Like	like	IN
cord-306948-wkisfz1m	114	2	most	most	JJS
cord-306948-wkisfz1m	114	3	RNA	RNA	NNP
cord-306948-wkisfz1m	114	4	viruses	virus	NNS
cord-306948-wkisfz1m	114	5	,	,	,
cord-306948-wkisfz1m	114	6	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	114	7	genome	genome	NN
cord-306948-wkisfz1m	114	8	has	have	VBZ
cord-306948-wkisfz1m	114	9	evolved	evolve	VBN
cord-306948-wkisfz1m	114	10	to	to	TO
cord-306948-wkisfz1m	114	11	optimal	optimal	JJ
cord-306948-wkisfz1m	114	12	fitness	fitness	NN
cord-306948-wkisfz1m	114	13	,	,	,
cord-306948-wkisfz1m	114	14	and	and	CC
cord-306948-wkisfz1m	114	15	most	most	JJS
cord-306948-wkisfz1m	114	16	of	of	IN
cord-306948-wkisfz1m	114	17	the	the	DT
cord-306948-wkisfz1m	114	18	genetic	genetic	JJ
cord-306948-wkisfz1m	114	19	information	information	NN
cord-306948-wkisfz1m	114	20	seems	seem	VBZ
cord-306948-wkisfz1m	114	21	to	to	TO
cord-306948-wkisfz1m	114	22	be	be	VB
cord-306948-wkisfz1m	114	23	essential	essential	JJ
cord-306948-wkisfz1m	114	24	(	(	-LRB-
cord-306948-wkisfz1m	115	1	Verheije	Verheije	NNP
cord-306948-wkisfz1m	115	2	et	et	FW
cord-306948-wkisfz1m	115	3	al	al	NNP
cord-306948-wkisfz1m	115	4	.	.	NNP
cord-306948-wkisfz1m	115	5	,	,	,
cord-306948-wkisfz1m	115	6	2001	2001	CD
cord-306948-wkisfz1m	115	7	)	)	-RRB-
cord-306948-wkisfz1m	115	8	.	.	.
cord-306948-wkisfz1m	116	1	Notably	notably	RB
cord-306948-wkisfz1m	116	2	,	,	,
cord-306948-wkisfz1m	116	3	the	the	DT
cord-306948-wkisfz1m	116	4	3	3	CD
cord-306948-wkisfz1m	116	5	0proximal	0proximal	JJ
cord-306948-wkisfz1m	116	6	portion	portion	NN
cord-306948-wkisfz1m	116	7	of	of	IN
cord-306948-wkisfz1m	116	8	the	the	DT
cord-306948-wkisfz1m	116	9	genome	genome	NN
cord-306948-wkisfz1m	116	10	is	be	VBZ
cord-306948-wkisfz1m	116	11	compact	compact	JJ
cord-306948-wkisfz1m	116	12	and	and	CC
cord-306948-wkisfz1m	116	13	organized	organize	VBN
cord-306948-wkisfz1m	116	14	to	to	TO
cord-306948-wkisfz1m	116	15	contain	contain	VB
cord-306948-wkisfz1m	116	16	eight	eight	CD
cord-306948-wkisfz1m	116	17	genes	gene	NNS
cord-306948-wkisfz1m	116	18	,	,	,
cord-306948-wkisfz1m	116	19	most	most	JJS
cord-306948-wkisfz1m	116	20	of	of	IN
cord-306948-wkisfz1m	116	21	which	which	WDT
cord-306948-wkisfz1m	116	22	overlap	overlap	VBP
cord-306948-wkisfz1m	116	23	with	with	IN
cord-306948-wkisfz1m	116	24	neighboring	neighboring	NN
cord-306948-wkisfz1m	116	25	genes	gene	NNS
cord-306948-wkisfz1m	116	26	(	(	-LRB-
cord-306948-wkisfz1m	116	27	Snijder	Snijder	NNP
cord-306948-wkisfz1m	116	28	et	et	NNP
cord-306948-wkisfz1m	116	29	al	al	NNP
cord-306948-wkisfz1m	116	30	.	.	NNP
cord-306948-wkisfz1m	116	31	,	,	,
cord-306948-wkisfz1m	116	32	2013	2013	CD
cord-306948-wkisfz1m	116	33	)	)	-RRB-
cord-306948-wkisfz1m	116	34	.	.	.
cord-306948-wkisfz1m	117	1	The	the	DT
cord-306948-wkisfz1m	117	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	117	3	genome	genome	NN
cord-306948-wkisfz1m	117	4	is	be	VBZ
cord-306948-wkisfz1m	117	5	complex	complex	JJ
cord-306948-wkisfz1m	117	6	and	and	CC
cord-306948-wkisfz1m	117	7	the	the	DT
cord-306948-wkisfz1m	117	8	engineering	engineering	NN
cord-306948-wkisfz1m	117	9	of	of	IN
cord-306948-wkisfz1m	117	10	such	such	PDT
cord-306948-wkisfz1m	117	11	a	a	DT
cord-306948-wkisfz1m	117	12	compact	compact	JJ
cord-306948-wkisfz1m	117	13	viral	viral	JJ
cord-306948-wkisfz1m	117	14	genome	genome	NN
cord-306948-wkisfz1m	117	15	is	be	VBZ
cord-306948-wkisfz1m	117	16	a	a	DT
cord-306948-wkisfz1m	117	17	challenge	challenge	NN
cord-306948-wkisfz1m	117	18	.	.	.
cord-306948-wkisfz1m	118	1	In	in	IN
cord-306948-wkisfz1m	118	2	addition	addition	NN
cord-306948-wkisfz1m	118	3	,	,	,
cord-306948-wkisfz1m	118	4	minor	minor	JJ
cord-306948-wkisfz1m	118	5	alternations	alternation	NNS
cord-306948-wkisfz1m	118	6	in	in	IN
cord-306948-wkisfz1m	118	7	conserved	conserved	JJ
cord-306948-wkisfz1m	118	8	regions	region	NNS
cord-306948-wkisfz1m	118	9	or	or	CC
cord-306948-wkisfz1m	118	10	functional	functional	JJ
cord-306948-wkisfz1m	118	11	domains	domain	NNS
cord-306948-wkisfz1m	118	12	in	in	IN
cord-306948-wkisfz1m	118	13	the	the	DT
cord-306948-wkisfz1m	118	14	genome	genome	NN
cord-306948-wkisfz1m	118	15	almost	almost	RB
cord-306948-wkisfz1m	118	16	inevitably	inevitably	RB
cord-306948-wkisfz1m	118	17	lead	lead	VBP
cord-306948-wkisfz1m	118	18	to	to	IN
cord-306948-wkisfz1m	118	19	non	non	JJ
cord-306948-wkisfz1m	118	20	-	-	JJ
cord-306948-wkisfz1m	118	21	viable	viable	JJ
cord-306948-wkisfz1m	118	22	consequences	consequence	NNS
cord-306948-wkisfz1m	119	1	Kroese	Kroese	NNP
cord-306948-wkisfz1m	119	2	et	et	NNP
cord-306948-wkisfz1m	119	3	al	al	NNP
cord-306948-wkisfz1m	119	4	.	.	NNP
cord-306948-wkisfz1m	119	5	,	,	,
cord-306948-wkisfz1m	119	6	2008	2008	CD
cord-306948-wkisfz1m	119	7	;	;	:
cord-306948-wkisfz1m	119	8	.	.	.
cord-306948-wkisfz1m	120	1	Despite	despite	IN
cord-306948-wkisfz1m	120	2	such	such	JJ
cord-306948-wkisfz1m	120	3	difficulties	difficulty	NNS
cord-306948-wkisfz1m	120	4	,	,	,
cord-306948-wkisfz1m	120	5	some	some	DT
cord-306948-wkisfz1m	120	6	genetic	genetic	JJ
cord-306948-wkisfz1m	120	7	manipulations	manipulation	NNS
cord-306948-wkisfz1m	120	8	for	for	IN
cord-306948-wkisfz1m	120	9	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	120	10	have	have	VBP
cord-306948-wkisfz1m	120	11	been	be	VBN
cord-306948-wkisfz1m	120	12	successful	successful	JJ
cord-306948-wkisfz1m	120	13	.	.	.
cord-306948-wkisfz1m	121	1	Mutation	mutation	NN
cord-306948-wkisfz1m	121	2	,	,	,
cord-306948-wkisfz1m	121	3	deletion	deletion	NN
cord-306948-wkisfz1m	121	4	,	,	,
cord-306948-wkisfz1m	121	5	insertion	insertion	NN
cord-306948-wkisfz1m	121	6	,	,	,
cord-306948-wkisfz1m	121	7	and	and	CC
cord-306948-wkisfz1m	121	8	substitution	substitution	NN
cord-306948-wkisfz1m	121	9	are	be	VBP
cord-306948-wkisfz1m	121	10	major	major	JJ
cord-306948-wkisfz1m	121	11	approaches	approach	NNS
cord-306948-wkisfz1m	121	12	to	to	IN
cord-306948-wkisfz1m	121	13	viral	viral	JJ
cord-306948-wkisfz1m	121	14	genome	genome	NN
cord-306948-wkisfz1m	121	15	manipulation	manipulation	NN
cord-306948-wkisfz1m	121	16	.	.	.
cord-306948-wkisfz1m	122	1	Due	due	IN
cord-306948-wkisfz1m	122	2	to	to	IN
cord-306948-wkisfz1m	122	3	the	the	DT
cord-306948-wkisfz1m	122	4	large	large	JJ
cord-306948-wkisfz1m	122	5	genome	genome	NN
cord-306948-wkisfz1m	122	6	of	of	IN
cord-306948-wkisfz1m	122	7	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	122	8	,	,	,
cord-306948-wkisfz1m	122	9	shuttle	shuttle	NN
cord-306948-wkisfz1m	122	10	plasmids	plasmid	NNS
cord-306948-wkisfz1m	122	11	have	have	VBP
cord-306948-wkisfz1m	122	12	been	be	VBN
cord-306948-wkisfz1m	122	13	used	use	VBN
cord-306948-wkisfz1m	122	14	as	as	IN
cord-306948-wkisfz1m	122	15	an	an	DT
cord-306948-wkisfz1m	122	16	intermediate	intermediate	JJ
cord-306948-wkisfz1m	122	17	platform	platform	NN
cord-306948-wkisfz1m	122	18	to	to	TO
cord-306948-wkisfz1m	122	19	contain	contain	VB
cord-306948-wkisfz1m	122	20	the	the	DT
cord-306948-wkisfz1m	122	21	target	target	NN
cord-306948-wkisfz1m	122	22	viral	viral	JJ
cord-306948-wkisfz1m	122	23	genomic	genomic	JJ
cord-306948-wkisfz1m	122	24	sequence	sequence	NN
cord-306948-wkisfz1m	122	25	with	with	IN
cord-306948-wkisfz1m	122	26	a	a	DT
cord-306948-wkisfz1m	122	27	pair	pair	NN
cord-306948-wkisfz1m	122	28	of	of	IN
cord-306948-wkisfz1m	122	29	unique	unique	JJ
cord-306948-wkisfz1m	122	30	enzyme	enzyme	NN
cord-306948-wkisfz1m	122	31	sites	site	NNS
cord-306948-wkisfz1m	122	32	at	at	IN
cord-306948-wkisfz1m	122	33	each	each	DT
cord-306948-wkisfz1m	122	34	end	end	NN
cord-306948-wkisfz1m	122	35	.	.	.
cord-306948-wkisfz1m	123	1	Mutations	mutation	NNS
cord-306948-wkisfz1m	123	2	are	be	VBP
cord-306948-wkisfz1m	123	3	introduced	introduce	VBN
cord-306948-wkisfz1m	123	4	to	to	TO
cord-306948-wkisfz1m	123	5	target	target	VB
cord-306948-wkisfz1m	123	6	sites	site	NNS
cord-306948-wkisfz1m	123	7	or	or	CC
cord-306948-wkisfz1m	123	8	sequences	sequence	NNS
cord-306948-wkisfz1m	123	9	in	in	IN
cord-306948-wkisfz1m	123	10	the	the	DT
cord-306948-wkisfz1m	123	11	shuttle	shuttle	NN
cord-306948-wkisfz1m	123	12	plasmid	plasmid	NN
cord-306948-wkisfz1m	123	13	.	.	.
cord-306948-wkisfz1m	124	1	The	the	DT
cord-306948-wkisfz1m	124	2	biological	biological	JJ
cord-306948-wkisfz1m	124	3	functions	function	NNS
cord-306948-wkisfz1m	124	4	of	of	IN
cord-306948-wkisfz1m	124	5	PLP1a	PLP1a	NNP
cord-306948-wkisfz1m	124	6	and	and	CC
cord-306948-wkisfz1m	124	7	PLP1b	PLP1b	NNPS
cord-306948-wkisfz1m	124	8	in	in	IN
cord-306948-wkisfz1m	124	9	nsp1	nsp1	NNS
cord-306948-wkisfz1m	124	10	,	,	,
cord-306948-wkisfz1m	124	11	conserved	conserve	VBN
cord-306948-wkisfz1m	124	12	cysteine	cysteine	NN
cord-306948-wkisfz1m	124	13	residues	residue	NNS
cord-306948-wkisfz1m	124	14	at	at	IN
cord-306948-wkisfz1m	124	15	C49	C49	NNP
cord-306948-wkisfz1m	124	16	and	and	CC
cord-306948-wkisfz1m	124	17	C54	C54	NNP
cord-306948-wkisfz1m	124	18	in	in	IN
cord-306948-wkisfz1m	124	19	the	the	DT
cord-306948-wkisfz1m	124	20	E	e	NN
cord-306948-wkisfz1m	124	21	protein	protein	NN
cord-306948-wkisfz1m	124	22	,	,	,
cord-306948-wkisfz1m	124	23	N	n	NN
cord-306948-wkisfz1m	124	24	-	-	HYPH
cord-306948-wkisfz1m	124	25	linked	link	VBN
cord-306948-wkisfz1m	124	26	glycosylation	glycosylation	NN
cord-306948-wkisfz1m	124	27	sites	site	NNS
cord-306948-wkisfz1m	124	28	in	in	IN
cord-306948-wkisfz1m	124	29	GP3	GP3	NNP
cord-306948-wkisfz1m	124	30	at	at	IN
cord-306948-wkisfz1m	124	31	N131	N131	NNP
cord-306948-wkisfz1m	124	32	and	and	CC
cord-306948-wkisfz1m	124	33	GP5	GP5	NNP
cord-306948-wkisfz1m	124	34	at	at	IN
cord-306948-wkisfz1m	124	35	N34	N34	NNP
cord-306948-wkisfz1m	124	36	,	,	,
cord-306948-wkisfz1m	124	37	N44	N44	NNP
cord-306948-wkisfz1m	124	38	,	,	,
cord-306948-wkisfz1m	124	39	and	and	CC
cord-306948-wkisfz1m	124	40	N51	N51	NNP
cord-306948-wkisfz1m	124	41	,	,	,
cord-306948-wkisfz1m	124	42	cysteines	cysteine	NNS
cord-306948-wkisfz1m	124	43	at	at	IN
cord-306948-wkisfz1m	124	44	C23	C23	NNP
cord-306948-wkisfz1m	124	45	,	,	,
cord-306948-wkisfz1m	124	46	C75	C75	NNP
cord-306948-wkisfz1m	124	47	,	,	,
cord-306948-wkisfz1m	124	48	and	and	CC
cord-306948-wkisfz1m	124	49	C90	C90	NNP
cord-306948-wkisfz1m	124	50	for	for	IN
cord-306948-wkisfz1m	124	51	homo	homo	NN
cord-306948-wkisfz1m	124	52	-	-	HYPH
cord-306948-wkisfz1m	124	53	dimerization	dimerization	NN
cord-306948-wkisfz1m	124	54	of	of	IN
cord-306948-wkisfz1m	124	55	N	n	CD
cord-306948-wkisfz1m	124	56	protein	protein	NN
cord-306948-wkisfz1m	124	57	,	,	,
cord-306948-wkisfz1m	124	58	and	and	CC
cord-306948-wkisfz1m	124	59	the	the	DT
cord-306948-wkisfz1m	124	60	motif	motif	NN
cord-306948-wkisfz1m	124	61	for	for	IN
cord-306948-wkisfz1m	124	62	nuclear	nuclear	JJ
cord-306948-wkisfz1m	124	63	localization	localization	NN
cord-306948-wkisfz1m	124	64	signal	signal	NN
cord-306948-wkisfz1m	124	65	(	(	-LRB-
cord-306948-wkisfz1m	124	66	NLS	NLS	NNP
cord-306948-wkisfz1m	124	67	)	)	-RRB-
cord-306948-wkisfz1m	124	68	of	of	IN
cord-306948-wkisfz1m	124	69	N	n	CD
cord-306948-wkisfz1m	124	70	have	have	VBP
cord-306948-wkisfz1m	124	71	been	be	VBN
cord-306948-wkisfz1m	124	72	mutated	mutate	VBN
cord-306948-wkisfz1m	124	73	to	to	TO
cord-306948-wkisfz1m	124	74	produce	produce	VB
cord-306948-wkisfz1m	124	75	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	124	76	mutants	mutant	NNS
cord-306948-wkisfz1m	125	1	Kroese	Kroese	NNP
cord-306948-wkisfz1m	125	2	et	et	NNP
cord-306948-wkisfz1m	125	3	al	al	NNP
cord-306948-wkisfz1m	125	4	.	.	NNP
cord-306948-wkisfz1m	125	5	,	,	,
cord-306948-wkisfz1m	125	6	2008	2008	CD
cord-306948-wkisfz1m	126	1	;	;	:
cord-306948-wkisfz1m	126	2	Pei	Pei	NNP
cord-306948-wkisfz1m	126	3	et	et	NNP
cord-306948-wkisfz1m	126	4	al	al	NNP
cord-306948-wkisfz1m	126	5	.	.	.
cord-306948-wkisfz1m	127	1	,	,	,
cord-306948-wkisfz1m	127	2	2009	2009	CD
cord-306948-wkisfz1m	127	3	;	;	:
cord-306948-wkisfz1m	127	4	Vu	Vu	NNP
cord-306948-wkisfz1m	127	5	et	et	FW
cord-306948-wkisfz1m	127	6	al	al	NNP
cord-306948-wkisfz1m	127	7	.	.	NNP
cord-306948-wkisfz1m	127	8	,	,	,
cord-306948-wkisfz1m	127	9	2011	2011	CD
cord-306948-wkisfz1m	127	10	)	)	-RRB-
cord-306948-wkisfz1m	127	11	.	.	.
cord-306948-wkisfz1m	128	1	Alanine	alanine	NN
cord-306948-wkisfz1m	128	2	scanning	scanning	NN
cord-306948-wkisfz1m	128	3	and	and	CC
cord-306948-wkisfz1m	128	4	protein	protein	NN
cord-306948-wkisfz1m	128	5	surface	surface	NN
cord-306948-wkisfz1m	128	6	accessibility	accessibility	NN
cord-306948-wkisfz1m	128	7	predictions	prediction	NNS
cord-306948-wkisfz1m	128	8	were	be	VBD
cord-306948-wkisfz1m	128	9	conducted	conduct	VBN
cord-306948-wkisfz1m	128	10	for	for	IN
cord-306948-wkisfz1m	128	11	identification	identification	NN
cord-306948-wkisfz1m	128	12	of	of	IN
cord-306948-wkisfz1m	128	13	residues	residue	NNS
cord-306948-wkisfz1m	128	14	for	for	IN
cord-306948-wkisfz1m	128	15	type	type	NN
cord-306948-wkisfz1m	129	1	I	-PRON-	PRP
cord-306948-wkisfz1m	129	2	IFNs	ifns	VBP
cord-306948-wkisfz1m	129	3	or	or	CC
cord-306948-wkisfz1m	129	4	TNF	TNF	NNP
cord-306948-wkisfz1m	129	5	-	-	:
cord-306948-wkisfz1m	129	6	a	a	DT
cord-306948-wkisfz1m	129	7	antagonism	antagonism	NN
cord-306948-wkisfz1m	129	8	of	of	IN
cord-306948-wkisfz1m	129	9	nsp1	nsp1	NNS
cord-306948-wkisfz1m	129	10	,	,	,
cord-306948-wkisfz1m	129	11	and	and	CC
cord-306948-wkisfz1m	129	12	specific	specific	JJ
cord-306948-wkisfz1m	129	13	residues	residue	NNS
cord-306948-wkisfz1m	129	14	have	have	VBP
cord-306948-wkisfz1m	129	15	been	be	VBN
cord-306948-wkisfz1m	129	16	mutated	mutate	VBN
cord-306948-wkisfz1m	129	17	in	in	IN
cord-306948-wkisfz1m	129	18	the	the	DT
cord-306948-wkisfz1m	129	19	infectious	infectious	JJ
cord-306948-wkisfz1m	129	20	clones	clone	NNS
cord-306948-wkisfz1m	129	21	Li	Li	NNP
cord-306948-wkisfz1m	129	22	et	et	NNP
cord-306948-wkisfz1m	129	23	al	al	NNP
cord-306948-wkisfz1m	129	24	.	.	NNP
cord-306948-wkisfz1m	129	25	,	,	,
cord-306948-wkisfz1m	129	26	2013	2013	CD
cord-306948-wkisfz1m	129	27	;	;	:
cord-306948-wkisfz1m	130	1	Subramaniam	Subramaniam	NNP
cord-306948-wkisfz1m	130	2	et	et	NNP
cord-306948-wkisfz1m	130	3	al	al	NNP
cord-306948-wkisfz1m	130	4	.	.	NNP
cord-306948-wkisfz1m	130	5	,	,	,
cord-306948-wkisfz1m	130	6	2012	2012	CD
cord-306948-wkisfz1m	130	7	)	)	-RRB-
cord-306948-wkisfz1m	130	8	.	.	.
cord-306948-wkisfz1m	131	1	Mutations	mutation	NNS
cord-306948-wkisfz1m	131	2	have	have	VBP
cord-306948-wkisfz1m	131	3	also	also	RB
cord-306948-wkisfz1m	131	4	been	be	VBN
cord-306948-wkisfz1m	131	5	introduced	introduce	VBN
cord-306948-wkisfz1m	131	6	to	to	IN
cord-306948-wkisfz1m	131	7	knockout	knockout	NN
cord-306948-wkisfz1m	131	8	genes	gene	NNS
cord-306948-wkisfz1m	131	9	by	by	IN
cord-306948-wkisfz1m	131	10	changing	change	VBG
cord-306948-wkisfz1m	131	11	the	the	DT
cord-306948-wkisfz1m	131	12	translation	translation	NN
cord-306948-wkisfz1m	131	13	N	N	NNP
cord-306948-wkisfz1m	131	14	/	/	SYM
cord-306948-wkisfz1m	131	15	A	A	NNP
cord-306948-wkisfz1m	131	16	,	,	,
cord-306948-wkisfz1m	131	17	not	not	RB
cord-306948-wkisfz1m	131	18	application	application	NN
cord-306948-wkisfz1m	131	19	.	.	.
cord-306948-wkisfz1m	132	1	a	a	DT
cord-306948-wkisfz1m	132	2	The	the	DT
cord-306948-wkisfz1m	132	3	individual	individual	JJ
cord-306948-wkisfz1m	132	4	time	time	NN
cord-306948-wkisfz1m	132	5	of	of	IN
cord-306948-wkisfz1m	132	6	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	132	7	infectious	infectious	JJ
cord-306948-wkisfz1m	132	8	clones	clone	NNS
cord-306948-wkisfz1m	132	9	construction	construction	NN
cord-306948-wkisfz1m	132	10	referred	refer	VBD
cord-306948-wkisfz1m	132	11	to	to	IN
cord-306948-wkisfz1m	132	12	the	the	DT
cord-306948-wkisfz1m	132	13	date	date	NN
cord-306948-wkisfz1m	132	14	of	of	IN
cord-306948-wkisfz1m	132	15	each	each	DT
cord-306948-wkisfz1m	132	16	publication	publication	NN
cord-306948-wkisfz1m	132	17	.	.	.
cord-306948-wkisfz1m	133	1	b	b	LS
cord-306948-wkisfz1m	133	2	Genotype	Genotype	NNP
cord-306948-wkisfz1m	133	3	I	I	NNP
cord-306948-wkisfz1m	133	4	and	and	CC
cord-306948-wkisfz1m	133	5	II	II	NNP
cord-306948-wkisfz1m	133	6	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	133	7	represents	represent	VBZ
cord-306948-wkisfz1m	133	8	European	european	JJ
cord-306948-wkisfz1m	133	9	and	and	CC
cord-306948-wkisfz1m	133	10	North	North	NNP
cord-306948-wkisfz1m	133	11	America	America	NNP
cord-306948-wkisfz1m	133	12	strains	strain	NNS
cord-306948-wkisfz1m	133	13	,	,	,
cord-306948-wkisfz1m	133	14	respectively	respectively	RB
cord-306948-wkisfz1m	133	15	.	.	.
cord-306948-wkisfz1m	134	1	c	c	LS
cord-306948-wkisfz1m	134	2	Sequences	Sequences	NNPS
cord-306948-wkisfz1m	134	3	of	of	IN
cord-306948-wkisfz1m	134	4	full	full	JJ
cord-306948-wkisfz1m	134	5	-	-	HYPH
cord-306948-wkisfz1m	134	6	genome	genome	NN
cord-306948-wkisfz1m	134	7	cDNA	cdna	NN
cord-306948-wkisfz1m	134	8	clone	clone	NN
cord-306948-wkisfz1m	134	9	rather	rather	RB
cord-306948-wkisfz1m	134	10	than	than	IN
cord-306948-wkisfz1m	134	11	complete	complete	JJ
cord-306948-wkisfz1m	134	12	genome	genome	NN
cord-306948-wkisfz1m	134	13	sequences	sequence	NNS
cord-306948-wkisfz1m	134	14	of	of	IN
cord-306948-wkisfz1m	134	15	parental	parental	JJ
cord-306948-wkisfz1m	134	16	virus	virus	NN
cord-306948-wkisfz1m	134	17	are	be	VBP
cord-306948-wkisfz1m	134	18	listed	list	VBN
cord-306948-wkisfz1m	134	19	.	.	.
cord-306948-wkisfz1m	135	1	d	d	LS
cord-306948-wkisfz1m	135	2	The	the	DT
cord-306948-wkisfz1m	135	3	genome	genome	NN
cord-306948-wkisfz1m	135	4	area	area	NN
cord-306948-wkisfz1m	135	5	in	in	IN
cord-306948-wkisfz1m	135	6	which	which	WDT
cord-306948-wkisfz1m	135	7	the	the	DT
cord-306948-wkisfz1m	135	8	restricted	restricted	JJ
cord-306948-wkisfz1m	135	9	enzyme	enzyme	NN
cord-306948-wkisfz1m	135	10	sites	site	NNS
cord-306948-wkisfz1m	135	11	are	be	VBP
cord-306948-wkisfz1m	135	12	introduced	introduce	VBN
cord-306948-wkisfz1m	135	13	is	be	VBZ
cord-306948-wkisfz1m	135	14	indicated	indicate	VBN
cord-306948-wkisfz1m	135	15	with	with	IN
cord-306948-wkisfz1m	135	16	brackets	bracket	NNS
cord-306948-wkisfz1m	135	17	.	.	.
cord-306948-wkisfz1m	136	1	The	the	DT
cord-306948-wkisfz1m	136	2	position	position	NN
cord-306948-wkisfz1m	136	3	where	where	WRB
cord-306948-wkisfz1m	136	4	single	single	JJ
cord-306948-wkisfz1m	136	5	mutations	mutation	NNS
cord-306948-wkisfz1m	136	6	are	be	VBP
cord-306948-wkisfz1m	136	7	introduced	introduce	VBN
cord-306948-wkisfz1m	136	8	is	be	VBZ
cord-306948-wkisfz1m	136	9	given	give	VBN
cord-306948-wkisfz1m	136	10	.	.	.
cord-306948-wkisfz1m	137	1	e	e	LS
cord-306948-wkisfz1m	137	2	Genome	Genome	NNP
cord-306948-wkisfz1m	137	3	-	-	HYPH
cord-306948-wkisfz1m	137	4	length	length	NN
cord-306948-wkisfz1m	137	5	cDNA	cdna	NN
cord-306948-wkisfz1m	137	6	clones	clone	NNS
cord-306948-wkisfz1m	137	7	of	of	IN
cord-306948-wkisfz1m	137	8	pABV414	pABV414	NNP
cord-306948-wkisfz1m	137	9	and	and	CC
cord-306948-wkisfz1m	137	10	pABV416	pABV416	NNP
cord-306948-wkisfz1m	137	11	encode	encode	VB
cord-306948-wkisfz1m	137	12	identical	identical	JJ
cord-306948-wkisfz1m	137	13	viral	viral	JJ
cord-306948-wkisfz1m	137	14	protein	protein	NN
cord-306948-wkisfz1m	137	15	sequences	sequence	NNS
cord-306948-wkisfz1m	137	16	except	except	IN
cord-306948-wkisfz1m	137	17	for	for	IN
cord-306948-wkisfz1m	137	18	one	one	CD
cord-306948-wkisfz1m	137	19	amino	amino	NN
cord-306948-wkisfz1m	137	20	acid	acid	NN
cord-306948-wkisfz1m	137	21	at	at	IN
cord-306948-wkisfz1m	137	22	position	position	NN
cord-306948-wkisfz1m	137	23	1084	1084	CD
cord-306948-wkisfz1m	137	24	in	in	IN
cord-306948-wkisfz1m	137	25	ORF1a	ORF1a	NNP
cord-306948-wkisfz1m	137	26	,	,	,
cord-306948-wkisfz1m	137	27	which	which	WDT
cord-306948-wkisfz1m	137	28	are	be	VBP
cord-306948-wkisfz1m	137	29	a	a	DT
cord-306948-wkisfz1m	137	30	Pro	Pro	NNP
cord-306948-wkisfz1m	137	31	in	in	IN
cord-306948-wkisfz1m	137	32	pABV414	pABV414	NNP
cord-306948-wkisfz1m	137	33	and	and	CC
cord-306948-wkisfz1m	137	34	a	a	DT
cord-306948-wkisfz1m	137	35	Leu	Leu	NNP
cord-306948-wkisfz1m	137	36	in	in	IN
cord-306948-wkisfz1m	137	37	pABV416	pABV416	NNP
cord-306948-wkisfz1m	137	38	.	.	.
cord-306948-wkisfz1m	138	1	f	f	NNP
cord-306948-wkisfz1m	139	1	The	the	DT
cord-306948-wkisfz1m	139	2	abbreviation	abbreviation	NN
cord-306948-wkisfz1m	139	3	,	,	,
cord-306948-wkisfz1m	140	1	NA	NA	NNP
cord-306948-wkisfz1m	140	2	I	-PRON-	PRP
cord-306948-wkisfz1m	140	3	,	,	,
cord-306948-wkisfz1m	140	4	in	in	IN
cord-306948-wkisfz1m	140	5	the	the	DT
cord-306948-wkisfz1m	140	6	genotype	genotype	NN
cord-306948-wkisfz1m	140	7	column	column	NN
cord-306948-wkisfz1m	140	8	represents	represent	VBZ
cord-306948-wkisfz1m	140	9	genotype	genotype	NN
cord-306948-wkisfz1m	140	10	I	-PRON-	PRP
cord-306948-wkisfz1m	140	11	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	140	12	isolated	isolate	VBN
cord-306948-wkisfz1m	140	13	in	in	IN
cord-306948-wkisfz1m	140	14	North	North	NNP
cord-306948-wkisfz1m	140	15	America	America	NNP
cord-306948-wkisfz1m	140	16	.	.	.
cord-306948-wkisfz1m	141	1	initiation	initiation	NNP
cord-306948-wkisfz1m	141	2	codon	codon	NNP
cord-306948-wkisfz1m	141	3	,	,	,
cord-306948-wkisfz1m	141	4	and	and	CC
cord-306948-wkisfz1m	141	5	this	this	DT
cord-306948-wkisfz1m	141	6	approach	approach	NN
cord-306948-wkisfz1m	141	7	destroys	destroy	VBZ
cord-306948-wkisfz1m	141	8	the	the	DT
cord-306948-wkisfz1m	141	9	expression	expression	NN
cord-306948-wkisfz1m	141	10	of	of	IN
cord-306948-wkisfz1m	141	11	nsp1	nsp1	NNS
cord-306948-wkisfz1m	141	12	and	and	CC
cord-306948-wkisfz1m	141	13	E	e	NN
cord-306948-wkisfz1m	141	14	protein	protein	NN
cord-306948-wkisfz1m	141	15	Tijms	Tijms	NNP
cord-306948-wkisfz1m	141	16	et	et	FW
cord-306948-wkisfz1m	141	17	al	al	NNP
cord-306948-wkisfz1m	141	18	.	.	NNP
cord-306948-wkisfz1m	141	19	,	,	,
cord-306948-wkisfz1m	141	20	2001	2001	CD
cord-306948-wkisfz1m	141	21	)	)	-RRB-
cord-306948-wkisfz1m	141	22	.	.	.
cord-306948-wkisfz1m	142	1	Deletion	deletion	NN
cord-306948-wkisfz1m	142	2	of	of	IN
cord-306948-wkisfz1m	142	3	genomic	genomic	JJ
cord-306948-wkisfz1m	142	4	sequences	sequence	NNS
cord-306948-wkisfz1m	142	5	has	have	VBZ
cord-306948-wkisfz1m	142	6	been	be	VBN
cord-306948-wkisfz1m	142	7	applied	apply	VBN
cord-306948-wkisfz1m	142	8	to	to	IN
cord-306948-wkisfz1m	142	9	identifying	identify	VBG
cord-306948-wkisfz1m	142	10	non	non	JJ
cord-306948-wkisfz1m	142	11	-	-	JJ
cord-306948-wkisfz1m	142	12	essential	essential	JJ
cord-306948-wkisfz1m	142	13	regions	region	NNS
cord-306948-wkisfz1m	142	14	for	for	IN
cord-306948-wkisfz1m	142	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	142	16	replication	replication	NN
cord-306948-wkisfz1m	142	17	or	or	CC
cord-306948-wkisfz1m	142	18	to	to	IN
cord-306948-wkisfz1m	142	19	obtaining	obtain	VBG
cord-306948-wkisfz1m	142	20	attenuated	attenuated	JJ
cord-306948-wkisfz1m	142	21	live	live	JJ
cord-306948-wkisfz1m	142	22	vaccine	vaccine	NN
cord-306948-wkisfz1m	142	23	candidates	candidate	NNS
cord-306948-wkisfz1m	142	24	(	(	-LRB-
cord-306948-wkisfz1m	142	25	Verheije	Verheije	NNP
cord-306948-wkisfz1m	142	26	et	et	FW
cord-306948-wkisfz1m	142	27	al	al	NNP
cord-306948-wkisfz1m	142	28	.	.	NNP
cord-306948-wkisfz1m	142	29	,	,	,
cord-306948-wkisfz1m	142	30	2001	2001	CD
cord-306948-wkisfz1m	142	31	)	)	-RRB-
cord-306948-wkisfz1m	142	32	.	.	.
cord-306948-wkisfz1m	143	1	Inter	inter	JJ
cord-306948-wkisfz1m	143	2	-	-	JJ
cord-306948-wkisfz1m	143	3	genotypic	genotypic	JJ
cord-306948-wkisfz1m	143	4	sequence	sequence	NN
cord-306948-wkisfz1m	143	5	alignments	alignment	NNS
cord-306948-wkisfz1m	143	6	between	between	IN
cord-306948-wkisfz1m	143	7	genotype	genotype	NN
cord-306948-wkisfz1m	143	8	1	1	CD
cord-306948-wkisfz1m	143	9	and	and	CC
cord-306948-wkisfz1m	143	10	genotype	genotype	NN
cord-306948-wkisfz1m	143	11	2	2	CD
cord-306948-wkisfz1m	143	12	reveal	reveal	VBP
cord-306948-wkisfz1m	143	13	the	the	DT
cord-306948-wkisfz1m	143	14	regions	region	NNS
cord-306948-wkisfz1m	143	15	of	of	IN
cord-306948-wkisfz1m	143	16	sequence	sequence	NN
cord-306948-wkisfz1m	143	17	heterogeneity	heterogeneity	NN
cord-306948-wkisfz1m	143	18	suggesting	suggest	VBG
cord-306948-wkisfz1m	143	19	the	the	DT
cord-306948-wkisfz1m	143	20	potential	potential	NN
cord-306948-wkisfz1m	143	21	to	to	TO
cord-306948-wkisfz1m	143	22	tolerate	tolerate	VB
cord-306948-wkisfz1m	143	23	the	the	DT
cord-306948-wkisfz1m	143	24	deletions	deletion	NNS
cord-306948-wkisfz1m	143	25	,	,	,
cord-306948-wkisfz1m	143	26	and	and	CC
cord-306948-wkisfz1m	143	27	non	non	JJ
cord-306948-wkisfz1m	143	28	-	-	JJ
cord-306948-wkisfz1m	143	29	essential	essential	JJ
cord-306948-wkisfz1m	143	30	regions	region	NNS
cord-306948-wkisfz1m	143	31	in	in	IN
cord-306948-wkisfz1m	143	32	the	the	DT
cord-306948-wkisfz1m	143	33	N	n	CD
cord-306948-wkisfz1m	143	34	gene	gene	NN
cord-306948-wkisfz1m	143	35	and	and	CC
cord-306948-wkisfz1m	143	36	3	3	CD
cord-306948-wkisfz1m	143	37	0	0	CD
cord-306948-wkisfz1m	143	38	-UTR	-UTR	.
cord-306948-wkisfz1m	144	1	(	(	-LRB-
cord-306948-wkisfz1m	144	2	Table	table	NN
cord-306948-wkisfz1m	144	3	2	2	CD
cord-306948-wkisfz1m	144	4	;	;	.
cord-306948-wkisfz1m	145	1	Sun	Sun	NNP
cord-306948-wkisfz1m	145	2	et	et	NNP
cord-306948-wkisfz1m	145	3	al	al	NNP
cord-306948-wkisfz1m	145	4	.	.	.
cord-306948-wkisfz1m	146	1	,	,	,
cord-306948-wkisfz1m	146	2	2010b	2010b	CD
cord-306948-wkisfz1m	146	3	;	;	:
cord-306948-wkisfz1m	147	1	Tan	Tan	NNP
cord-306948-wkisfz1m	147	2	et	et	FW
cord-306948-wkisfz1m	147	3	al	al	NNP
cord-306948-wkisfz1m	147	4	.	.	NNP
cord-306948-wkisfz1m	147	5	,	,	,
cord-306948-wkisfz1m	147	6	2011	2011	CD
cord-306948-wkisfz1m	147	7	)	)	-RRB-
cord-306948-wkisfz1m	147	8	.	.	.
cord-306948-wkisfz1m	148	1	The	the	DT
cord-306948-wkisfz1m	148	2	hypervariable	hypervariable	JJ
cord-306948-wkisfz1m	148	3	regions	region	NNS
cord-306948-wkisfz1m	148	4	have	have	VBP
cord-306948-wkisfz1m	148	5	been	be	VBN
cord-306948-wkisfz1m	148	6	observed	observe	VBN
cord-306948-wkisfz1m	148	7	in	in	IN
cord-306948-wkisfz1m	148	8	the	the	DT
cord-306948-wkisfz1m	148	9	nsp2	nsp2	NNP
cord-306948-wkisfz1m	148	10	gene	gene	NN
cord-306948-wkisfz1m	148	11	(	(	-LRB-
cord-306948-wkisfz1m	148	12	Fang	Fang	NNP
cord-306948-wkisfz1m	148	13	et	et	FW
cord-306948-wkisfz1m	148	14	al	al	NNP
cord-306948-wkisfz1m	148	15	.	.	NNP
cord-306948-wkisfz1m	148	16	,	,	,
cord-306948-wkisfz1m	148	17	2004	2004	CD
cord-306948-wkisfz1m	148	18	;	;	:
cord-306948-wkisfz1m	148	19	Gao	Gao	NNP
cord-306948-wkisfz1m	148	20	et	et	NNP
cord-306948-wkisfz1m	148	21	al	al	NNP
cord-306948-wkisfz1m	148	22	.	.	NNP
cord-306948-wkisfz1m	148	23	,	,	,
cord-306948-wkisfz1m	148	24	2004	2004	CD
cord-306948-wkisfz1m	148	25	;	;	:
cord-306948-wkisfz1m	149	1	Ni	Ni	NNP
cord-306948-wkisfz1m	149	2	et	et	NNP
cord-306948-wkisfz1m	149	3	al	al	NNP
cord-306948-wkisfz1m	149	4	.	.	NNP
cord-306948-wkisfz1m	149	5	,	,	,
cord-306948-wkisfz1m	149	6	2013	2013	CD
cord-306948-wkisfz1m	149	7	;	;	:
cord-306948-wkisfz1m	149	8	Shen	Shen	NNP
cord-306948-wkisfz1m	149	9	et	et	NNP
cord-306948-wkisfz1m	149	10	al	al	NNP
cord-306948-wkisfz1m	149	11	.	.	NNP
cord-306948-wkisfz1m	149	12	,	,	,
cord-306948-wkisfz1m	149	13	2000	2000	CD
cord-306948-wkisfz1m	149	14	;	;	:
cord-306948-wkisfz1m	149	15	Tian	Tian	NNP
cord-306948-wkisfz1m	149	16	et	et	NNP
cord-306948-wkisfz1m	149	17	al	al	NNP
cord-306948-wkisfz1m	149	18	.	.	NNP
cord-306948-wkisfz1m	149	19	,	,	,
cord-306948-wkisfz1m	149	20	2007	2007	CD
cord-306948-wkisfz1m	149	21	)	)	-RRB-
cord-306948-wkisfz1m	149	22	,	,	,
cord-306948-wkisfz1m	149	23	suggesting	suggest	VBG
cord-306948-wkisfz1m	149	24	the	the	DT
cord-306948-wkisfz1m	149	25	existence	existence	NN
cord-306948-wkisfz1m	149	26	of	of	IN
cord-306948-wkisfz1m	149	27	a	a	DT
cord-306948-wkisfz1m	149	28	non	non	JJ
cord-306948-wkisfz1m	149	29	-	-	JJ
cord-306948-wkisfz1m	149	30	essential	essential	JJ
cord-306948-wkisfz1m	149	31	region	region	NN
cord-306948-wkisfz1m	149	32	in	in	IN
cord-306948-wkisfz1m	149	33	nsp2	nsp2	NNP
cord-306948-wkisfz1m	150	1	(	(	-LRB-
cord-306948-wkisfz1m	150	2	Chen	Chen	NNP
cord-306948-wkisfz1m	150	3	et	et	NNP
cord-306948-wkisfz1m	150	4	al	al	NNP
cord-306948-wkisfz1m	150	5	.	.	.
cord-306948-wkisfz1m	151	1	,	,	,
cord-306948-wkisfz1m	151	2	2010b	2010b	CD
cord-306948-wkisfz1m	151	3	;	;	:
cord-306948-wkisfz1m	151	4	Han	Han	NNP
cord-306948-wkisfz1m	151	5	et	et	NNP
cord-306948-wkisfz1m	151	6	al	al	NNP
cord-306948-wkisfz1m	151	7	.	.	NNP
cord-306948-wkisfz1m	151	8	,	,	,
cord-306948-wkisfz1m	151	9	2007	2007	CD
cord-306948-wkisfz1m	151	10	;	;	.
cord-306948-wkisfz1m	152	1	Ran	run	VBD
cord-306948-wkisfz1m	152	2	et	et	FW
cord-306948-wkisfz1m	152	3	al	al	NNP
cord-306948-wkisfz1m	152	4	.	.	NNP
cord-306948-wkisfz1m	152	5	,	,	,
cord-306948-wkisfz1m	152	6	2008	2008	CD
cord-306948-wkisfz1m	153	1	;	;	:
cord-306948-wkisfz1m	153	2	Xu	Xu	NNP
cord-306948-wkisfz1m	153	3	et	et	NNP
cord-306948-wkisfz1m	153	4	al	al	NNP
cord-306948-wkisfz1m	153	5	.	.	NNP
cord-306948-wkisfz1m	153	6	,	,	,
cord-306948-wkisfz1m	153	7	2012b	2012b	CD
cord-306948-wkisfz1m	153	8	)	)	-RRB-
cord-306948-wkisfz1m	153	9	.	.	.
cord-306948-wkisfz1m	154	1	Deletion	deletion	NN
cord-306948-wkisfz1m	154	2	of	of	IN
cord-306948-wkisfz1m	154	3	ORF2	ORF2	NNP
cord-306948-wkisfz1m	154	4	or	or	CC
cord-306948-wkisfz1m	154	5	ORF4	ORF4	NNP
cord-306948-wkisfz1m	154	6	results	result	NNS
cord-306948-wkisfz1m	154	7	in	in	IN
cord-306948-wkisfz1m	154	8	the	the	DT
cord-306948-wkisfz1m	154	9	absence	absence	NN
cord-306948-wkisfz1m	154	10	of	of	IN
cord-306948-wkisfz1m	154	11	infectivity	infectivity	NN
cord-306948-wkisfz1m	154	12	,	,	,
cord-306948-wkisfz1m	154	13	suggesting	suggest	VBG
cord-306948-wkisfz1m	154	14	the	the	DT
cord-306948-wkisfz1m	154	15	requirement	requirement	NN
cord-306948-wkisfz1m	154	16	of	of	IN
cord-306948-wkisfz1m	154	17	GP2	GP2	NNP
cord-306948-wkisfz1m	154	18	and	and	CC
cord-306948-wkisfz1m	154	19	GP4	GP4	NNP
cord-306948-wkisfz1m	154	20	proteins	protein	NNS
cord-306948-wkisfz1m	154	21	for	for	IN
cord-306948-wkisfz1m	154	22	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	154	23	infectivity	infectivity	NN
cord-306948-wkisfz1m	154	24	.	.	.
cord-306948-wkisfz1m	155	1	Insertion	insertion	NN
cord-306948-wkisfz1m	155	2	of	of	IN
cord-306948-wkisfz1m	155	3	additional	additional	JJ
cord-306948-wkisfz1m	155	4	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	155	5	to	to	IN
cord-306948-wkisfz1m	155	6	the	the	DT
cord-306948-wkisfz1m	155	7	viral	viral	JJ
cord-306948-wkisfz1m	155	8	genome	genome	NN
cord-306948-wkisfz1m	155	9	expands	expand	VBZ
cord-306948-wkisfz1m	155	10	the	the	DT
cord-306948-wkisfz1m	155	11	scope	scope	NN
cord-306948-wkisfz1m	155	12	of	of	IN
cord-306948-wkisfz1m	155	13	modifications	modification	NNS
cord-306948-wkisfz1m	155	14	.	.	.
cord-306948-wkisfz1m	156	1	An	an	DT
cord-306948-wkisfz1m	156	2	attempt	attempt	NN
cord-306948-wkisfz1m	156	3	was	be	VBD
cord-306948-wkisfz1m	156	4	made	make	VBN
cord-306948-wkisfz1m	156	5	to	to	TO
cord-306948-wkisfz1m	156	6	separate	separate	VB
cord-306948-wkisfz1m	156	7	overlapping	overlapping	JJ
cord-306948-wkisfz1m	156	8	regions	region	NNS
cord-306948-wkisfz1m	156	9	of	of	IN
cord-306948-wkisfz1m	156	10	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	156	11	structural	structural	JJ
cord-306948-wkisfz1m	156	12	protein	protein	NN
cord-306948-wkisfz1m	156	13	genes	gene	NNS
cord-306948-wkisfz1m	156	14	,	,	,
cord-306948-wkisfz1m	156	15	and	and	CC
cord-306948-wkisfz1m	156	16	three	three	CD
cord-306948-wkisfz1m	156	17	restriction	restriction	NN
cord-306948-wkisfz1m	156	18	enzyme	enzyme	NN
cord-306948-wkisfz1m	156	19	sites	site	NNS
cord-306948-wkisfz1m	156	20	were	be	VBD
cord-306948-wkisfz1m	156	21	inserted	insert	VBN
cord-306948-wkisfz1m	156	22	between	between	IN
cord-306948-wkisfz1m	156	23	ORFs	ORFs	NNP
cord-306948-wkisfz1m	156	24	5/6	5/6	CD
cord-306948-wkisfz1m	156	25	and	and	CC
cord-306948-wkisfz1m	156	26	ORFs	ORFs	NNP
cord-306948-wkisfz1m	156	27	6/7	6/7	CD
cord-306948-wkisfz1m	157	1	(	(	-LRB-
cord-306948-wkisfz1m	157	2	Yu	Yu	NNP
cord-306948-wkisfz1m	157	3	et	et	FW
cord-306948-wkisfz1m	157	4	al	al	NNP
cord-306948-wkisfz1m	157	5	.	.	NNP
cord-306948-wkisfz1m	157	6	,	,	,
cord-306948-wkisfz1m	157	7	2009	2009	CD
cord-306948-wkisfz1m	157	8	)	)	-RRB-
cord-306948-wkisfz1m	157	9	,	,	,
cord-306948-wkisfz1m	157	10	which	which	WDT
cord-306948-wkisfz1m	157	11	produced	produce	VBD
cord-306948-wkisfz1m	157	12	viable	viable	JJ
cord-306948-wkisfz1m	157	13	viruses	virus	NNS
cord-306948-wkisfz1m	157	14	.	.	.
cord-306948-wkisfz1m	158	1	The	the	DT
cord-306948-wkisfz1m	158	2	possibility	possibility	NN
cord-306948-wkisfz1m	158	3	of	of	IN
cord-306948-wkisfz1m	158	4	expressing	express	VBG
cord-306948-wkisfz1m	158	5	foreign	foreign	JJ
cord-306948-wkisfz1m	158	6	genes	gene	NNS
cord-306948-wkisfz1m	158	7	using	use	VBG
cord-306948-wkisfz1m	158	8	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	158	9	has	have	VBZ
cord-306948-wkisfz1m	158	10	been	be	VBN
cord-306948-wkisfz1m	158	11	explored	explore	VBN
cord-306948-wkisfz1m	158	12	;	;	:
cord-306948-wkisfz1m	158	13	the	the	DT
cord-306948-wkisfz1m	158	14	nsp2	nsp2	NNP
cord-306948-wkisfz1m	158	15	gene	gene	NN
cord-306948-wkisfz1m	158	16	was	be	VBD
cord-306948-wkisfz1m	158	17	utilized	utilize	VBN
cord-306948-wkisfz1m	158	18	as	as	IN
cord-306948-wkisfz1m	158	19	an	an	DT
cord-306948-wkisfz1m	158	20	insertion	insertion	NN
cord-306948-wkisfz1m	158	21	site	site	NN
cord-306948-wkisfz1m	158	22	for	for	IN
cord-306948-wkisfz1m	158	23	expressions	expression	NNS
cord-306948-wkisfz1m	158	24	of	of	IN
cord-306948-wkisfz1m	158	25	green	green	JJ
cord-306948-wkisfz1m	158	26	fluorescent	fluorescent	NN
cord-306948-wkisfz1m	158	27	protein	protein	NN
cord-306948-wkisfz1m	158	28	(	(	-LRB-
cord-306948-wkisfz1m	158	29	GFP	GFP	NNP
cord-306948-wkisfz1m	158	30	)	)	-RRB-
cord-306948-wkisfz1m	158	31	and	and	CC
cord-306948-wkisfz1m	158	32	FLAG	flag	NN
cord-306948-wkisfz1m	158	33	tag	tag	NN
cord-306948-wkisfz1m	158	34	(	(	-LRB-
cord-306948-wkisfz1m	158	35	Fang	Fang	NNP
cord-306948-wkisfz1m	158	36	et	et	FW
cord-306948-wkisfz1m	158	37	al	al	NNP
cord-306948-wkisfz1m	158	38	.	.	NNP
cord-306948-wkisfz1m	158	39	,	,	,
cord-306948-wkisfz1m	158	40	2006b	2006b	CD
cord-306948-wkisfz1m	158	41	;	;	:
cord-306948-wkisfz1m	158	42	Kim	Kim	NNP
cord-306948-wkisfz1m	158	43	et	et	NNP
cord-306948-wkisfz1m	158	44	al	al	NNP
cord-306948-wkisfz1m	158	45	.	.	NNP
cord-306948-wkisfz1m	158	46	,	,	,
cord-306948-wkisfz1m	158	47	2007	2007	CD
cord-306948-wkisfz1m	158	48	)	)	-RRB-
cord-306948-wkisfz1m	158	49	.	.	.
cord-306948-wkisfz1m	159	1	An	an	DT
cord-306948-wkisfz1m	159	2	alternate	alternate	JJ
cord-306948-wkisfz1m	159	3	approach	approach	NN
cord-306948-wkisfz1m	159	4	was	be	VBD
cord-306948-wkisfz1m	159	5	taken	take	VBN
cord-306948-wkisfz1m	159	6	to	to	TO
cord-306948-wkisfz1m	159	7	insert	insert	VB
cord-306948-wkisfz1m	159	8	foreign	foreign	JJ
cord-306948-wkisfz1m	159	9	genes	gene	NNS
cord-306948-wkisfz1m	159	10	within	within	IN
cord-306948-wkisfz1m	159	11	a	a	DT
cord-306948-wkisfz1m	159	12	structural	structural	JJ
cord-306948-wkisfz1m	159	13	gene	gene	NN
cord-306948-wkisfz1m	159	14	;	;	:
cord-306948-wkisfz1m	159	15	for	for	IN
cord-306948-wkisfz1m	159	16	example	example	NN
cord-306948-wkisfz1m	159	17	,	,	,
cord-306948-wkisfz1m	159	18	a	a	DT
cord-306948-wkisfz1m	159	19	small	small	JJ
cord-306948-wkisfz1m	159	20	portion	portion	NN
cord-306948-wkisfz1m	159	21	of	of	IN
cord-306948-wkisfz1m	159	22	the	the	DT
cord-306948-wkisfz1m	159	23	influenza	influenza	NN
cord-306948-wkisfz1m	159	24	virus	virus	NN
cord-306948-wkisfz1m	159	25	hemagglutinin	hemagglutinin	NNP
cord-306948-wkisfz1m	159	26	(	(	-LRB-
cord-306948-wkisfz1m	159	27	HA	HA	NNP
cord-306948-wkisfz1m	159	28	)	)	-RRB-
cord-306948-wkisfz1m	159	29	gene	gene	NN
cord-306948-wkisfz1m	159	30	into	into	IN
cord-306948-wkisfz1m	159	31	the	the	DT
cord-306948-wkisfz1m	159	32	5	5	CD
cord-306948-wkisfz1m	159	33	0	0	CD
cord-306948-wkisfz1m	159	34	or	or	CC
cord-306948-wkisfz1m	159	35	3	3	CD
cord-306948-wkisfz1m	159	36	0	0	CD
cord-306948-wkisfz1m	159	37	end	end	NN
cord-306948-wkisfz1m	159	38	of	of	IN
cord-306948-wkisfz1m	159	39	ORF7	ORF7	NNP
cord-306948-wkisfz1m	159	40	of	of	IN
cord-306948-wkisfz1m	159	41	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	160	1	(	(	-LRB-
cord-306948-wkisfz1m	160	2	Bramel	Bramel	NNP
cord-306948-wkisfz1m	160	3	-	-	HYPH
cord-306948-wkisfz1m	160	4	Verheije	Verheije	NNP
cord-306948-wkisfz1m	160	5	et	et	FW
cord-306948-wkisfz1m	160	6	al	al	NNP
cord-306948-wkisfz1m	160	7	.	.	NNP
cord-306948-wkisfz1m	160	8	,	,	,
cord-306948-wkisfz1m	160	9	2000	2000	CD
cord-306948-wkisfz1m	160	10	)	)	-RRB-
cord-306948-wkisfz1m	160	11	.	.	.
cord-306948-wkisfz1m	161	1	However	however	RB
cord-306948-wkisfz1m	161	2	,	,	,
cord-306948-wkisfz1m	161	3	the	the	DT
cord-306948-wkisfz1m	161	4	insertion	insertion	NN
cord-306948-wkisfz1m	161	5	of	of	IN
cord-306948-wkisfz1m	161	6	HA	HA	NNP
cord-306948-wkisfz1m	161	7	to	to	IN
cord-306948-wkisfz1m	161	8	N	n	CD
cord-306948-wkisfz1m	161	9	gene	gene	NN
cord-306948-wkisfz1m	161	10	resulted	result	VBD
cord-306948-wkisfz1m	161	11	in	in	IN
cord-306948-wkisfz1m	161	12	a	a	DT
cord-306948-wkisfz1m	161	13	nonviable	nonviable	JJ
cord-306948-wkisfz1m	161	14	virus	virus	NN
cord-306948-wkisfz1m	161	15	.	.	.
cord-306948-wkisfz1m	162	1	A	a	DT
cord-306948-wkisfz1m	162	2	strategy	strategy	NN
cord-306948-wkisfz1m	162	3	utilizing	utilize	VBG
cord-306948-wkisfz1m	162	4	the	the	DT
cord-306948-wkisfz1m	162	5	mechanism	mechanism	NN
cord-306948-wkisfz1m	162	6	of	of	IN
cord-306948-wkisfz1m	162	7	transcription	transcription	NN
cord-306948-wkisfz1m	162	8	of	of	IN
cord-306948-wkisfz1m	162	9	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	162	10	for	for	IN
cord-306948-wkisfz1m	162	11	foreign	foreign	JJ
cord-306948-wkisfz1m	162	12	gene	gene	NN
cord-306948-wkisfz1m	162	13	expression	expression	NN
cord-306948-wkisfz1m	162	14	is	be	VBZ
cord-306948-wkisfz1m	162	15	of	of	IN
cord-306948-wkisfz1m	162	16	particular	particular	JJ
cord-306948-wkisfz1m	162	17	interest	interest	NN
cord-306948-wkisfz1m	162	18	.	.	.
cord-306948-wkisfz1m	163	1	Using	use	VBG
cord-306948-wkisfz1m	163	2	an	an	DT
cord-306948-wkisfz1m	163	3	infectious	infectious	JJ
cord-306948-wkisfz1m	163	4	clone	clone	NN
cord-306948-wkisfz1m	163	5	,	,	,
cord-306948-wkisfz1m	163	6	two	two	CD
cord-306948-wkisfz1m	163	7	unique	unique	JJ
cord-306948-wkisfz1m	163	8	enzyme	enzyme	NN
cord-306948-wkisfz1m	163	9	sites	site	NNS
cord-306948-wkisfz1m	163	10	have	have	VBP
cord-306948-wkisfz1m	163	11	been	be	VBN
cord-306948-wkisfz1m	163	12	introduced	introduce	VBN
cord-306948-wkisfz1m	163	13	between	between	IN
cord-306948-wkisfz1m	163	14	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	163	15	and	and	CC
cord-306948-wkisfz1m	163	16	ORF2	ORF2	NNP
cord-306948-wkisfz1m	163	17	,	,	,
cord-306948-wkisfz1m	163	18	and	and	CC
cord-306948-wkisfz1m	163	19	a	a	DT
cord-306948-wkisfz1m	163	20	copy	copy	NN
cord-306948-wkisfz1m	163	21	of	of	IN
cord-306948-wkisfz1m	163	22	the	the	DT
cord-306948-wkisfz1m	163	23	TRS6	TRS6	NNP
cord-306948-wkisfz1m	163	24	sequence	sequence	NN
cord-306948-wkisfz1m	163	25	was	be	VBD
cord-306948-wkisfz1m	163	26	inserted	insert	VBN
cord-306948-wkisfz1m	163	27	to	to	TO
cord-306948-wkisfz1m	163	28	replace	replace	VB
cord-306948-wkisfz1m	163	29	the	the	DT
cord-306948-wkisfz1m	163	30	TRS	TRS	NNP
cord-306948-wkisfz1m	163	31	designed	design	VBN
cord-306948-wkisfz1m	163	32	to	to	TO
cord-306948-wkisfz1m	163	33	synthesize	synthesize	VB
cord-306948-wkisfz1m	163	34	the	the	DT
cord-306948-wkisfz1m	163	35	mRNA	mrna	NN
cord-306948-wkisfz1m	163	36	for	for	IN
cord-306948-wkisfz1m	163	37	foreign	foreign	JJ
cord-306948-wkisfz1m	163	38	gene	gene	NN
cord-306948-wkisfz1m	163	39	expression	expression	NN
cord-306948-wkisfz1m	163	40	(	(	-LRB-
cord-306948-wkisfz1m	163	41	Fig	Fig	NNP
cord-306948-wkisfz1m	163	42	.	.	.
cord-306948-wkisfz1m	163	43	4	4	CD
cord-306948-wkisfz1m	163	44	)	)	-RRB-
cord-306948-wkisfz1m	164	1	Pei	Pei	NNP
cord-306948-wkisfz1m	164	2	et	et	NNP
cord-306948-wkisfz1m	164	3	al	al	NNP
cord-306948-wkisfz1m	164	4	.	.	NNP
cord-306948-wkisfz1m	164	5	,	,	,
cord-306948-wkisfz1m	164	6	2009	2009	CD
cord-306948-wkisfz1m	165	1	;	;	:
cord-306948-wkisfz1m	165	2	Yoo	Yoo	NNP
cord-306948-wkisfz1m	165	3	et	et	NNP
cord-306948-wkisfz1m	165	4	al	al	NNP
cord-306948-wkisfz1m	165	5	.	.	NNP
cord-306948-wkisfz1m	165	6	,	,	,
cord-306948-wkisfz1m	165	7	2004	2004	CD
cord-306948-wkisfz1m	165	8	)	)	-RRB-
cord-306948-wkisfz1m	165	9	.	.	.
cord-306948-wkisfz1m	166	1	The	the	DT
cord-306948-wkisfz1m	166	2	foreign	foreign	JJ
cord-306948-wkisfz1m	166	3	genes	gene	NNS
cord-306948-wkisfz1m	166	4	including	include	VBG
cord-306948-wkisfz1m	166	5	GFP	GFP	NNP
cord-306948-wkisfz1m	166	6	,	,	,
cord-306948-wkisfz1m	166	7	capsid	capsid	NN
cord-306948-wkisfz1m	166	8	protein	protein	NN
cord-306948-wkisfz1m	166	9	of	of	IN
cord-306948-wkisfz1m	166	10	porcine	porcine	JJ
cord-306948-wkisfz1m	166	11	circovirus	circovirus	NNP
cord-306948-wkisfz1m	166	12	type	type	NN
cord-306948-wkisfz1m	166	13	2	2	CD
cord-306948-wkisfz1m	166	14	(	(	-LRB-
cord-306948-wkisfz1m	166	15	PCV2	PCV2	NNP
cord-306948-wkisfz1m	166	16	)	)	-RRB-
cord-306948-wkisfz1m	166	17	,	,	,
cord-306948-wkisfz1m	166	18	Discosoma	Discosoma	NNP
cord-306948-wkisfz1m	166	19	sp	sp	NN
cord-306948-wkisfz1m	166	20	.	.	.
cord-306948-wkisfz1m	167	1	(	(	-LRB-
cord-306948-wkisfz1m	167	2	sea	sea	NN
cord-306948-wkisfz1m	167	3	anemone	anemone	NN
cord-306948-wkisfz1m	167	4	)	)	-RRB-
cord-306948-wkisfz1m	167	5	red	red	JJ
cord-306948-wkisfz1m	167	6	fluorescent	fluorescent	NN
cord-306948-wkisfz1m	167	7	protein	protein	NN
cord-306948-wkisfz1m	167	8	(	(	-LRB-
cord-306948-wkisfz1m	167	9	DsRED	DsRED	NNP
cord-306948-wkisfz1m	167	10	)	)	-RRB-
cord-306948-wkisfz1m	167	11	,	,	,
cord-306948-wkisfz1m	167	12	Renilla	Renilla	NNP
cord-306948-wkisfz1m	167	13	luciferase	luciferase	NN
cord-306948-wkisfz1m	167	14	(	(	-LRB-
cord-306948-wkisfz1m	167	15	Rluc	Rluc	NNP
cord-306948-wkisfz1m	167	16	)	)	-RRB-
cord-306948-wkisfz1m	167	17	,	,	,
cord-306948-wkisfz1m	167	18	IFN	IFN	NNP
cord-306948-wkisfz1m	167	19	-	-	HYPH
cord-306948-wkisfz1m	167	20	a1	a1	NNP
cord-306948-wkisfz1m	167	21	,	,	,
cord-306948-wkisfz1m	167	22	IFN	IFN	NNP
cord-306948-wkisfz1m	167	23	-	-	HYPH
cord-306948-wkisfz1m	167	24	b	b	NNP
cord-306948-wkisfz1m	167	25	,	,	,
cord-306948-wkisfz1m	167	26	IFN	IFN	NNP
cord-306948-wkisfz1m	167	27	-	-	HYPH
cord-306948-wkisfz1m	167	28	d3	d3	NNP
cord-306948-wkisfz1m	167	29	,	,	,
cord-306948-wkisfz1m	167	30	and	and	CC
cord-306948-wkisfz1m	167	31	IFN	IFN	NNP
cord-306948-wkisfz1m	167	32	-	-	HYPH
cord-306948-wkisfz1m	167	33	v5	v5	NNP
cord-306948-wkisfz1m	167	34	have	have	VBP
cord-306948-wkisfz1m	167	35	all	all	DT
cord-306948-wkisfz1m	167	36	been	be	VBN
cord-306948-wkisfz1m	167	37	expressed	express	VBN
cord-306948-wkisfz1m	167	38	as	as	IN
cord-306948-wkisfz1m	167	39	an	an	DT
cord-306948-wkisfz1m	167	40	independent	independent	JJ
cord-306948-wkisfz1m	167	41	transcript	transcript	NN
cord-306948-wkisfz1m	167	42	using	use	VBG
cord-306948-wkisfz1m	167	43	this	this	DT
cord-306948-wkisfz1m	167	44	approach	approach	NN
cord-306948-wkisfz1m	167	45	(	(	-LRB-
cord-306948-wkisfz1m	167	46	Table	table	NN
cord-306948-wkisfz1m	167	47	3	3	CD
cord-306948-wkisfz1m	167	48	;	;	:
cord-306948-wkisfz1m	167	49	Pei	Pei	NNP
cord-306948-wkisfz1m	167	50	et	et	NNP
cord-306948-wkisfz1m	167	51	al	al	NNP
cord-306948-wkisfz1m	167	52	.	.	.
cord-306948-wkisfz1m	168	1	,	,	,
cord-306948-wkisfz1m	168	2	2009	2009	CD
cord-306948-wkisfz1m	168	3	;	;	:
cord-306948-wkisfz1m	168	4	Sang	Sang	NNP
cord-306948-wkisfz1m	168	5	et	et	FW
cord-306948-wkisfz1m	168	6	al	al	NNP
cord-306948-wkisfz1m	168	7	.	.	NNP
cord-306948-wkisfz1m	168	8	,	,	,
cord-306948-wkisfz1m	168	9	2012	2012	CD
cord-306948-wkisfz1m	168	10	)	)	-RRB-
cord-306948-wkisfz1m	168	11	.	.	.
cord-306948-wkisfz1m	169	1	Multiple	multiple	JJ
cord-306948-wkisfz1m	169	2	genes	gene	NNS
cord-306948-wkisfz1m	169	3	,	,	,
cord-306948-wkisfz1m	169	4	a	a	DT
cord-306948-wkisfz1m	169	5	single	single	JJ
cord-306948-wkisfz1m	169	6	gene	gene	NN
cord-306948-wkisfz1m	169	7	,	,	,
cord-306948-wkisfz1m	169	8	or	or	CC
cord-306948-wkisfz1m	169	9	partial	partial	JJ
cord-306948-wkisfz1m	169	10	sequence	sequence	NN
cord-306948-wkisfz1m	169	11	of	of	IN
cord-306948-wkisfz1m	169	12	the	the	DT
cord-306948-wkisfz1m	169	13	viral	viral	JJ
cord-306948-wkisfz1m	169	14	genome	genome	NN
cord-306948-wkisfz1m	169	15	have	have	VBP
cord-306948-wkisfz1m	169	16	been	be	VBN
cord-306948-wkisfz1m	169	17	substituted	substitute	VBN
cord-306948-wkisfz1m	169	18	with	with	IN
cord-306948-wkisfz1m	169	19	corresponding	correspond	VBG
cord-306948-wkisfz1m	169	20	sequences	sequence	NNS
cord-306948-wkisfz1m	169	21	from	from	IN
cord-306948-wkisfz1m	169	22	other	other	JJ
cord-306948-wkisfz1m	169	23	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	169	24	for	for	IN
cord-306948-wkisfz1m	169	25	chimeric	chimeric	JJ
cord-306948-wkisfz1m	169	26	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	169	27	construction	construction	NN
cord-306948-wkisfz1m	169	28	.	.	.
cord-306948-wkisfz1m	170	1	The	the	DT
cord-306948-wkisfz1m	170	2	first	first	JJ
cord-306948-wkisfz1m	170	3	chimeric	chimeric	JJ
cord-306948-wkisfz1m	170	4	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	170	5	was	be	VBD
cord-306948-wkisfz1m	170	6	generated	generate	VBN
cord-306948-wkisfz1m	170	7	using	use	VBG
cord-306948-wkisfz1m	170	8	an	an	DT
cord-306948-wkisfz1m	170	9	EAV	EAV	NNP
cord-306948-wkisfz1m	170	10	infectious	infectious	JJ
cord-306948-wkisfz1m	170	11	clone	clone	NN
cord-306948-wkisfz1m	170	12	as	as	IN
cord-306948-wkisfz1m	170	13	a	a	DT
cord-306948-wkisfz1m	170	14	backbone	backbone	NN
cord-306948-wkisfz1m	170	15	,	,	,
cord-306948-wkisfz1m	170	16	and	and	CC
cord-306948-wkisfz1m	170	17	ectodomains	ectodomain	NNS
cord-306948-wkisfz1m	170	18	of	of	IN
cord-306948-wkisfz1m	170	19	two	two	CD
cord-306948-wkisfz1m	170	20	membrane	membrane	NN
cord-306948-wkisfz1m	170	21	proteins	protein	NNS
cord-306948-wkisfz1m	170	22	,	,	,
cord-306948-wkisfz1m	170	23	GP5	GP5	NNP
cord-306948-wkisfz1m	170	24	and	and	CC
cord-306948-wkisfz1m	170	25	M	M	NNP
cord-306948-wkisfz1m	170	26	,	,	,
cord-306948-wkisfz1m	170	27	were	be	VBD
cord-306948-wkisfz1m	170	28	substituted	substitute	VBN
cord-306948-wkisfz1m	170	29	with	with	IN
cord-306948-wkisfz1m	170	30	the	the	DT
cord-306948-wkisfz1m	170	31	corresponding	correspond	VBG
cord-306948-wkisfz1m	170	32	sequences	sequence	NNS
cord-306948-wkisfz1m	170	33	from	from	IN
cord-306948-wkisfz1m	170	34	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	170	35	or	or	CC
cord-306948-wkisfz1m	170	36	LDV	LDV	NNP
cord-306948-wkisfz1m	170	37	(	(	-LRB-
cord-306948-wkisfz1m	170	38	Dobbe	Dobbe	NNP
cord-306948-wkisfz1m	170	39	et	et	FW
cord-306948-wkisfz1m	170	40	al	al	NNP
cord-306948-wkisfz1m	170	41	.	.	NNP
cord-306948-wkisfz1m	170	42	,	,	,
cord-306948-wkisfz1m	170	43	2001	2001	CD
cord-306948-wkisfz1m	170	44	)	)	-RRB-
cord-306948-wkisfz1m	170	45	.	.	.
cord-306948-wkisfz1m	171	1	These	these	DT
cord-306948-wkisfz1m	171	2	chimeric	chimeric	JJ
cord-306948-wkisfz1m	171	3	viruses	virus	NNS
cord-306948-wkisfz1m	171	4	were	be	VBD
cord-306948-wkisfz1m	171	5	viable	viable	JJ
cord-306948-wkisfz1m	171	6	,	,	,
cord-306948-wkisfz1m	171	7	and	and	CC
cord-306948-wkisfz1m	171	8	additional	additional	JJ
cord-306948-wkisfz1m	171	9	chimeric	chimeric	JJ
cord-306948-wkisfz1m	171	10	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	171	11	have	have	VBP
cord-306948-wkisfz1m	171	12	been	be	VBN
cord-306948-wkisfz1m	171	13	constructed	construct	VBN
cord-306948-wkisfz1m	171	14	(	(	-LRB-
cord-306948-wkisfz1m	171	15	Table	Table	NNP
cord-306948-wkisfz1m	171	16	4	4	CD
cord-306948-wkisfz1m	171	17	)	)	-RRB-
cord-306948-wkisfz1m	171	18	.	.	.
cord-306948-wkisfz1m	172	1	The	the	DT
cord-306948-wkisfz1m	172	2	construction	construction	NN
cord-306948-wkisfz1m	172	3	of	of	IN
cord-306948-wkisfz1m	172	4	intra	intra	JJ
cord-306948-wkisfz1m	172	5	-	-	JJ
cord-306948-wkisfz1m	172	6	or	or	CC
cord-306948-wkisfz1m	172	7	intergenotypic	intergenotypic	JJ
cord-306948-wkisfz1m	173	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	173	2	chimeras	chimera	NNS
cord-306948-wkisfz1m	173	3	is	be	VBZ
cord-306948-wkisfz1m	173	4	maneuverable	maneuverable	JJ
cord-306948-wkisfz1m	173	5	,	,	,
cord-306948-wkisfz1m	173	6	and	and	CC
cord-306948-wkisfz1m	173	7	the	the	DT
cord-306948-wkisfz1m	173	8	regions	region	NNS
cord-306948-wkisfz1m	173	9	of	of	IN
cord-306948-wkisfz1m	173	10	5	5	CD
cord-306948-wkisfz1m	173	11	0	0	CD
cord-306948-wkisfz1m	173	12	-UTR	-utr	NN
cord-306948-wkisfz1m	173	13	,	,	,
cord-306948-wkisfz1m	173	14	non	non	JJ
cord-306948-wkisfz1m	173	15	-	-	JJ
cord-306948-wkisfz1m	173	16	structural	structural	JJ
cord-306948-wkisfz1m	173	17	genes	gene	NNS
cord-306948-wkisfz1m	173	18	,	,	,
cord-306948-wkisfz1m	173	19	and	and	CC
cord-306948-wkisfz1m	173	20	structural	structural	JJ
cord-306948-wkisfz1m	173	21	genes	gene	NNS
cord-306948-wkisfz1m	173	22	have	have	VBP
cord-306948-wkisfz1m	173	23	been	be	VBN
cord-306948-wkisfz1m	173	24	replaced	replace	VBN
cord-306948-wkisfz1m	174	1	(	(	-LRB-
cord-306948-wkisfz1m	174	2	Gao	Gao	NNP
cord-306948-wkisfz1m	174	3	et	et	NNP
cord-306948-wkisfz1m	174	4	al	al	NNP
cord-306948-wkisfz1m	174	5	.	.	NNP
cord-306948-wkisfz1m	174	6	,	,	,
cord-306948-wkisfz1m	174	7	2013	2013	CD
cord-306948-wkisfz1m	174	8	;	;	:
cord-306948-wkisfz1m	174	9	Lu	Lu	NNP
cord-306948-wkisfz1m	174	10	et	et	FW
cord-306948-wkisfz1m	174	11	al	al	NNP
cord-306948-wkisfz1m	174	12	.	.	NNP
cord-306948-wkisfz1m	174	13	,	,	,
cord-306948-wkisfz1m	174	14	2012	2012	CD
cord-306948-wkisfz1m	174	15	;	;	:
cord-306948-wkisfz1m	174	16	Tian	Tian	NNP
cord-306948-wkisfz1m	174	17	et	et	NNP
cord-306948-wkisfz1m	174	18	al	al	NNP
cord-306948-wkisfz1m	174	19	.	.	NNP
cord-306948-wkisfz1m	174	20	,	,	,
cord-306948-wkisfz1m	175	1	2011	2011	CD
cord-306948-wkisfz1m	176	1	Tian	Tian	NNP
cord-306948-wkisfz1m	176	2	et	et	NNP
cord-306948-wkisfz1m	176	3	al	al	NNP
cord-306948-wkisfz1m	176	4	.	.	.
cord-306948-wkisfz1m	177	1	,	,	,
cord-306948-wkisfz1m	177	2	,	,	,
cord-306948-wkisfz1m	177	3	2012	2012	CD
cord-306948-wkisfz1m	178	1	Vu	Vu	NNP
cord-306948-wkisfz1m	178	2	et	et	FW
cord-306948-wkisfz1m	178	3	al	al	NNP
cord-306948-wkisfz1m	178	4	.	.	NNP
cord-306948-wkisfz1m	178	5	,	,	,
cord-306948-wkisfz1m	178	6	2011	2011	CD
cord-306948-wkisfz1m	179	1	;	;	:
cord-306948-wkisfz1m	179	2	Zhou	Zhou	NNP
cord-306948-wkisfz1m	179	3	et	et	NNP
cord-306948-wkisfz1m	179	4	al	al	NNP
cord-306948-wkisfz1m	179	5	.	.	NNP
cord-306948-wkisfz1m	179	6	,	,	,
cord-306948-wkisfz1m	179	7	2009	2009	CD
cord-306948-wkisfz1m	179	8	)	)	-RRB-
cord-306948-wkisfz1m	179	9	.	.	.
cord-306948-wkisfz1m	180	1	To	to	TO
cord-306948-wkisfz1m	180	2	facilitate	facilitate	VB
cord-306948-wkisfz1m	180	3	the	the	DT
cord-306948-wkisfz1m	180	4	intra	intra	JJ
cord-306948-wkisfz1m	180	5	-	-	JJ
cord-306948-wkisfz1m	180	6	genotypic	genotypic	JJ
cord-306948-wkisfz1m	180	7	substitution	substitution	NN
cord-306948-wkisfz1m	180	8	,	,	,
cord-306948-wkisfz1m	180	9	a	a	DT
cord-306948-wkisfz1m	180	10	gene	gene	NN
cord-306948-wkisfz1m	180	11	-	-	HYPH
cord-306948-wkisfz1m	180	12	swapping	swap	VBG
cord-306948-wkisfz1m	180	13	mutagenesis	mutagenesis	NN
cord-306948-wkisfz1m	180	14	technique	technique	NN
cord-306948-wkisfz1m	180	15	has	have	VBZ
cord-306948-wkisfz1m	180	16	been	be	VBN
cord-306948-wkisfz1m	180	17	used	use	VBN
cord-306948-wkisfz1m	180	18	to	to	TO
cord-306948-wkisfz1m	180	19	substitute	substitute	VB
cord-306948-wkisfz1m	180	20	the	the	DT
cord-306948-wkisfz1m	180	21	structural	structural	JJ
cord-306948-wkisfz1m	180	22	genes	gene	NNS
cord-306948-wkisfz1m	180	23	(	(	-LRB-
cord-306948-wkisfz1m	180	24	Kim	Kim	NNP
cord-306948-wkisfz1m	180	25	and	and	CC
cord-306948-wkisfz1m	180	26	Yoon	Yoon	NNP
cord-306948-wkisfz1m	180	27	,	,	,
cord-306948-wkisfz1m	180	28	2008	2008	CD
cord-306948-wkisfz1m	180	29	)	)	-RRB-
cord-306948-wkisfz1m	180	30	.	.	.
cord-306948-wkisfz1m	181	1	Using	use	VBG
cord-306948-wkisfz1m	181	2	this	this	DT
cord-306948-wkisfz1m	181	3	technique	technique	NN
cord-306948-wkisfz1m	181	4	,	,	,
cord-306948-wkisfz1m	181	5	individual	individual	JJ
cord-306948-wkisfz1m	181	6	replacement	replacement	NN
cord-306948-wkisfz1m	181	7	of	of	IN
cord-306948-wkisfz1m	181	8	ORF2a	ORF2a	NNP
cord-306948-wkisfz1m	181	9	and	and	CC
cord-306948-wkisfz1m	181	10	ORF2	ORF2	NNP
cord-306948-wkisfz1m	181	11	through	through	IN
cord-306948-wkisfz1m	181	12	ORF6	ORF6	NNP
cord-306948-wkisfz1m	181	13	of	of	IN
cord-306948-wkisfz1m	181	14	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	181	15	was	be	VBD
cord-306948-wkisfz1m	181	16	successfully	successfully	RB
cord-306948-wkisfz1m	181	17	carried	carry	VBN
cord-306948-wkisfz1m	181	18	out	out	RP
cord-306948-wkisfz1m	181	19	with	with	IN
cord-306948-wkisfz1m	181	20	corresponding	correspond	VBG
cord-306948-wkisfz1m	181	21	ORFs	orfs	NN
cord-306948-wkisfz1m	181	22	from	from	IN
cord-306948-wkisfz1m	181	23	other	other	JJ
cord-306948-wkisfz1m	181	24	strains	strain	NNS
cord-306948-wkisfz1m	181	25	of	of	IN
cord-306948-wkisfz1m	181	26	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	181	27	including	include	VBG
cord-306948-wkisfz1m	181	28	JA142	JA142	NNP
cord-306948-wkisfz1m	181	29	,	,	,
cord-306948-wkisfz1m	181	30	SDSU73	SDSU73	NNP
cord-306948-wkisfz1m	181	31	,	,	,
cord-306948-wkisfz1m	181	32	PRRS124	PRRS124	NNP
cord-306948-wkisfz1m	181	33	,	,	,
cord-306948-wkisfz1m	181	34	and	and	CC
cord-306948-wkisfz1m	181	35	2M11715	2m11715	CD
cord-306948-wkisfz1m	182	1	(	(	-LRB-
cord-306948-wkisfz1m	182	2	Kim	Kim	NNP
cord-306948-wkisfz1m	182	3	and	and	CC
cord-306948-wkisfz1m	182	4	Yoon	Yoon	NNP
cord-306948-wkisfz1m	182	5	,	,	,
cord-306948-wkisfz1m	182	6	2008	2008	CD
cord-306948-wkisfz1m	182	7	)	)	-RRB-
cord-306948-wkisfz1m	182	8	.	.	.
cord-306948-wkisfz1m	182	9	 	 	_SP
cord-306948-wkisfz1m	183	1	4.2.1	4.2.1	LS
cord-306948-wkisfz1m	183	2	.	.	.
cord-306948-wkisfz1m	184	1	nsp2	nsp2	NNP
cord-306948-wkisfz1m	185	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	185	2	nsp2	nsp2	NNP
cord-306948-wkisfz1m	185	3	is	be	VBZ
cord-306948-wkisfz1m	185	4	a	a	DT
cord-306948-wkisfz1m	185	5	multifunctional	multifunctional	JJ
cord-306948-wkisfz1m	185	6	protein	protein	NN
cord-306948-wkisfz1m	185	7	that	that	WDT
cord-306948-wkisfz1m	185	8	undergoes	undergo	VBZ
cord-306948-wkisfz1m	185	9	remarkable	remarkable	JJ
cord-306948-wkisfz1m	185	10	genetic	genetic	JJ
cord-306948-wkisfz1m	185	11	variations	variation	NNS
cord-306948-wkisfz1m	185	12	.	.	.
cord-306948-wkisfz1m	186	1	The	the	DT
cord-306948-wkisfz1m	186	2	nsp2	nsp2	NNP
cord-306948-wkisfz1m	186	3	protein	protein	NN
cord-306948-wkisfz1m	186	4	consists	consist	VBZ
cord-306948-wkisfz1m	186	5	of	of	IN
cord-306948-wkisfz1m	186	6	five	five	CD
cord-306948-wkisfz1m	186	7	regions	region	NNS
cord-306948-wkisfz1m	186	8	:	:	:
cord-306948-wkisfz1m	186	9	hypervariable	hypervariable	NNP
cord-306948-wkisfz1m	186	10	region	region	NN
cord-306948-wkisfz1m	187	1	I	-PRON-	PRP
cord-306948-wkisfz1m	188	1	(	(	-LRB-
cord-306948-wkisfz1m	188	2	HV	HV	NNP
cord-306948-wkisfz1m	188	3	-	-	HYPH
cord-306948-wkisfz1m	188	4	I	I	NNP
cord-306948-wkisfz1m	188	5	)	)	-RRB-
cord-306948-wkisfz1m	188	6	,	,	.
cord-306948-wkisfz1m	189	1	PLP2	PLP2	NNP
cord-306948-wkisfz1m	189	2	cysteine	cysteine	NN
cord-306948-wkisfz1m	189	3	protease	protease	NN
cord-306948-wkisfz1m	189	4	core	core	NN
cord-306948-wkisfz1m	189	5	,	,	,
cord-306948-wkisfz1m	189	6	hypervariable	hypervariable	JJ
cord-306948-wkisfz1m	189	7	region	region	NN
cord-306948-wkisfz1m	189	8	II	II	NNP
cord-306948-wkisfz1m	189	9	(	(	-LRB-
cord-306948-wkisfz1m	189	10	HV	HV	NNP
cord-306948-wkisfz1m	189	11	-	-	HYPH
cord-306948-wkisfz1m	189	12	II	II	NNP
cord-306948-wkisfz1m	189	13	)	)	-RRB-
cord-306948-wkisfz1m	189	14	,	,	,
cord-306948-wkisfz1m	189	15	transmembrane	transmembrane	NN
cord-306948-wkisfz1m	189	16	regions	region	NNS
cord-306948-wkisfz1m	189	17	,	,	,
cord-306948-wkisfz1m	189	18	and	and	CC
cord-306948-wkisfz1m	189	19	a	a	DT
cord-306948-wkisfz1m	189	20	C	c	NN
cord-306948-wkisfz1m	189	21	-	-	HYPH
cord-306948-wkisfz1m	189	22	terminal	terminal	NN
cord-306948-wkisfz1m	189	23	tail	tail	NN
cord-306948-wkisfz1m	189	24	(	(	-LRB-
cord-306948-wkisfz1m	189	25	Fig	Fig	NNP
cord-306948-wkisfz1m	189	26	.	.	.
cord-306948-wkisfz1m	189	27	2A	2a	CD
cord-306948-wkisfz1m	189	28	;	;	.
cord-306948-wkisfz1m	190	1	Han	Han	NNP
cord-306948-wkisfz1m	190	2	et	et	NNP
cord-306948-wkisfz1m	190	3	al	al	NNP
cord-306948-wkisfz1m	190	4	.	.	NNP
cord-306948-wkisfz1m	190	5	,	,	,
cord-306948-wkisfz1m	190	6	2009	2009	CD
cord-306948-wkisfz1m	190	7	)	)	-RRB-
cord-306948-wkisfz1m	190	8	.	.	.
cord-306948-wkisfz1m	191	1	The	the	DT
cord-306948-wkisfz1m	191	2	PLP2	PLP2	NNP
cord-306948-wkisfz1m	191	3	cysteine	cysteine	NN
cord-306948-wkisfz1m	191	4	protease	protease	NN
cord-306948-wkisfz1m	191	5	domain	domain	NN
cord-306948-wkisfz1m	191	6	possesses	possess	VBZ
cord-306948-wkisfz1m	191	7	cisacting	cisacte	VBG
cord-306948-wkisfz1m	191	8	and	and	CC
cord-306948-wkisfz1m	191	9	trans	trans	JJ
cord-306948-wkisfz1m	191	10	-	-	JJ
cord-306948-wkisfz1m	191	11	acting	act	VBG
cord-306948-wkisfz1m	191	12	cleavage	cleavage	NN
cord-306948-wkisfz1m	191	13	activities	activity	NNS
cord-306948-wkisfz1m	191	14	and	and	CC
cord-306948-wkisfz1m	191	15	mediates	mediate	VBZ
cord-306948-wkisfz1m	191	16	its	-PRON-	PRP$
cord-306948-wkisfz1m	191	17	rapid	rapid	JJ
cord-306948-wkisfz1m	191	18	release	release	NN
cord-306948-wkisfz1m	191	19	from	from	IN
cord-306948-wkisfz1m	191	20	pp1a	pp1a	NNP
cord-306948-wkisfz1m	191	21	and	and	CC
cord-306948-wkisfz1m	191	22	pp1ab	pp1ab	NNP
cord-306948-wkisfz1m	191	23	(	(	-LRB-
cord-306948-wkisfz1m	191	24	Han	Han	NNP
cord-306948-wkisfz1m	191	25	et	et	NNP
cord-306948-wkisfz1m	191	26	al	al	NNP
cord-306948-wkisfz1m	191	27	.	.	.
cord-306948-wkisfz1m	192	1	,	,	,
cord-306948-wkisfz1m	192	2	2009	2009	CD
cord-306948-wkisfz1m	192	3	;	;	:
cord-306948-wkisfz1m	192	4	Snijder	Snijder	NNP
cord-306948-wkisfz1m	192	5	et	et	NNP
cord-306948-wkisfz1m	192	6	al	al	NNP
cord-306948-wkisfz1m	192	7	.	.	NNP
cord-306948-wkisfz1m	192	8	,	,	,
cord-306948-wkisfz1m	192	9	1995	1995	CD
cord-306948-wkisfz1m	192	10	)	)	-RRB-
cord-306948-wkisfz1m	192	11	.	.	.
cord-306948-wkisfz1m	193	1	Two	two	CD
cord-306948-wkisfz1m	193	2	sites	site	NNS
cord-306948-wkisfz1m	193	3	were	be	VBD
cord-306948-wkisfz1m	193	4	initially	initially	RB
cord-306948-wkisfz1m	193	5	predicted	predict	VBN
cord-306948-wkisfz1m	193	6	for	for	IN
cord-306948-wkisfz1m	193	7	nsp2	nsp2	NN
cord-306948-wkisfz1m	193	8	/	/	SYM
cord-306948-wkisfz1m	193	9	nsp3	nsp3	NNS
cord-306948-wkisfz1m	193	10	cleavage	cleavage	VBP
cord-306948-wkisfz1m	193	11	at	at	IN
cord-306948-wkisfz1m	193	12	981G/982	981g/982	CD
cord-306948-wkisfz1m	193	13	G	g	NN
cord-306948-wkisfz1m	193	14	and	and	CC
cord-306948-wkisfz1m	193	15	somewhere	somewhere	RB
cord-306948-wkisfz1m	193	16	at	at	IN
cord-306948-wkisfz1m	193	17	1196G/1197G/1198	1196g/1197g/1198	CD
cord-306948-wkisfz1m	193	18	G	g	NN
cord-306948-wkisfz1m	193	19	,	,	,
cord-306948-wkisfz1m	193	20	and	and	CC
cord-306948-wkisfz1m	193	21	recent	recent	JJ
cord-306948-wkisfz1m	193	22	studies	study	NNS
cord-306948-wkisfz1m	193	23	showed	show	VBD
cord-306948-wkisfz1m	193	24	the	the	DT
cord-306948-wkisfz1m	193	25	actual	actual	JJ
cord-306948-wkisfz1m	193	26	cleavage	cleavage	NN
cord-306948-wkisfz1m	193	27	occurs	occur	VBZ
cord-306948-wkisfz1m	193	28	at	at	IN
cord-306948-wkisfz1m	193	29	1196G/1197	1196g/1197	CD
cord-306948-wkisfz1m	193	30	G	g	NN
cord-306948-wkisfz1m	193	31	for	for	IN
cord-306948-wkisfz1m	193	32	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	194	1	(	(	-LRB-
cord-306948-wkisfz1m	194	2	Allende	Allende	NNP
cord-306948-wkisfz1m	194	3	et	et	NNP
cord-306948-wkisfz1m	194	4	al	al	NNP
cord-306948-wkisfz1m	194	5	.	.	NNP
cord-306948-wkisfz1m	194	6	,	,	,
cord-306948-wkisfz1m	194	7	1999	1999	CD
cord-306948-wkisfz1m	194	8	;	;	:
cord-306948-wkisfz1m	194	9	Han	Han	NNP
cord-306948-wkisfz1m	194	10	et	et	NNP
cord-306948-wkisfz1m	194	11	al	al	NNP
cord-306948-wkisfz1m	194	12	.	.	NNP
cord-306948-wkisfz1m	194	13	,	,	,
cord-306948-wkisfz1m	194	14	2009	2009	CD
cord-306948-wkisfz1m	195	1	;	;	:
cord-306948-wkisfz1m	195	2	Nelsen	Nelsen	NNP
cord-306948-wkisfz1m	195	3	et	et	NNP
cord-306948-wkisfz1m	195	4	al	al	NNP
cord-306948-wkisfz1m	195	5	.	.	NNP
cord-306948-wkisfz1m	195	6	,	,	,
cord-306948-wkisfz1m	195	7	1999	1999	CD
cord-306948-wkisfz1m	195	8	)	)	-RRB-
cord-306948-wkisfz1m	195	9	.	.	.
cord-306948-wkisfz1m	196	1	The	the	DT
cord-306948-wkisfz1m	196	2	corresponding	corresponding	JJ
cord-306948-wkisfz1m	196	3	cleavage	cleavage	NN
cord-306948-wkisfz1m	196	4	for	for	IN
cord-306948-wkisfz1m	196	5	EuroPRRSV	EuroPRRSV	NNP
cord-306948-wkisfz1m	196	6	SD01	SD01	NNP
cord-306948-wkisfz1m	196	7	-	-	HYPH
cord-306948-wkisfz1m	196	8	08	08	CD
cord-306948-wkisfz1m	196	9	likely	likely	RB
cord-306948-wkisfz1m	196	10	occurs	occur	VBZ
cord-306948-wkisfz1m	196	11	at	at	IN
cord-306948-wkisfz1m	196	12	1445GG/1447A	1445gg/1447a	CD
cord-306948-wkisfz1m	196	13	(	(	-LRB-
cord-306948-wkisfz1m	196	14	Fang	Fang	NNP
cord-306948-wkisfz1m	196	15	and	and	CC
cord-306948-wkisfz1m	196	16	Snijder	Snijder	NNP
cord-306948-wkisfz1m	196	17	,	,	,
cord-306948-wkisfz1m	196	18	2010	2010	CD
cord-306948-wkisfz1m	196	19	)	)	-RRB-
cord-306948-wkisfz1m	196	20	.	.	.
cord-306948-wkisfz1m	197	1	PLP2	PLP2	NNP
cord-306948-wkisfz1m	197	2	is	be	VBZ
cord-306948-wkisfz1m	197	3	as	as	IN
cord-306948-wkisfz1m	197	4	a	a	DT
cord-306948-wkisfz1m	197	5	member	member	NN
cord-306948-wkisfz1m	197	6	of	of	IN
cord-306948-wkisfz1m	197	7	the	the	DT
cord-306948-wkisfz1m	197	8	ovarian	ovarian	JJ
cord-306948-wkisfz1m	197	9	tumor	tumor	NN
cord-306948-wkisfz1m	197	10	domain	domain	NN
cord-306948-wkisfz1m	197	11	(	(	-LRB-
cord-306948-wkisfz1m	197	12	OTU	OTU	NNP
cord-306948-wkisfz1m	197	13	)	)	-RRB-
cord-306948-wkisfz1m	197	14	family	family	NN
cord-306948-wkisfz1m	197	15	of	of	IN
cord-306948-wkisfz1m	197	16	deubiquitinating	deubiquitinating	NN
cord-306948-wkisfz1m	197	17	enzymes	enzyme	NNS
cord-306948-wkisfz1m	197	18	,	,	,
cord-306948-wkisfz1m	197	19	and	and	CC
cord-306948-wkisfz1m	197	20	has	have	VBZ
cord-306948-wkisfz1m	197	21	shown	show	VBN
cord-306948-wkisfz1m	197	22	to	to	IN
cord-306948-wkisfz1m	197	23	deconjugate	deconjugate	NN
cord-306948-wkisfz1m	197	24	ubiquitin	ubiquitin	NN
cord-306948-wkisfz1m	197	25	(	(	-LRB-
cord-306948-wkisfz1m	197	26	Ub	Ub	NNP
cord-306948-wkisfz1m	197	27	)	)	-RRB-
cord-306948-wkisfz1m	197	28	and	and	CC
cord-306948-wkisfz1m	197	29	IFN	IFN	NNP
cord-306948-wkisfz1m	197	30	-	-	HYPH
cord-306948-wkisfz1m	197	31	stimulated	stimulate	VBN
cord-306948-wkisfz1m	197	32	gene	gene	NN
cord-306948-wkisfz1m	197	33	(	(	-LRB-
cord-306948-wkisfz1m	197	34	ISG	ISG	NNP
cord-306948-wkisfz1m	197	35	)	)	-RRB-
cord-306948-wkisfz1m	197	36	15	15	CD
cord-306948-wkisfz1m	197	37	from	from	IN
cord-306948-wkisfz1m	197	38	cellular	cellular	JJ
cord-306948-wkisfz1m	197	39	targets	target	NNS
cord-306948-wkisfz1m	197	40	.	.	.
cord-306948-wkisfz1m	198	1	This	this	DT
cord-306948-wkisfz1m	198	2	is	be	VBZ
cord-306948-wkisfz1m	198	3	an	an	DT
cord-306948-wkisfz1m	198	4	important	important	JJ
cord-306948-wkisfz1m	198	5	viral	viral	JJ
cord-306948-wkisfz1m	198	6	strategy	strategy	NN
cord-306948-wkisfz1m	198	7	inhibiting	inhibit	VBG
cord-306948-wkisfz1m	198	8	the	the	DT
cord-306948-wkisfz1m	198	9	Ub	Ub	NNP
cord-306948-wkisfz1m	198	10	-	-	HYPH
cord-306948-wkisfz1m	198	11	dependent	dependent	JJ
cord-306948-wkisfz1m	198	12	and	and	CC
cord-306948-wkisfz1m	198	13	ISG15-dependent	isg15-dependent	DT
cord-306948-wkisfz1m	198	14	host	host	NN
cord-306948-wkisfz1m	198	15	innate	innate	JJ
cord-306948-wkisfz1m	198	16	immune	immune	JJ
cord-306948-wkisfz1m	198	17	responses	response	NNS
cord-306948-wkisfz1m	198	18	(	(	-LRB-
cord-306948-wkisfz1m	198	19	Frias	Frias	NNP
cord-306948-wkisfz1m	198	20	-	-	HYPH
cord-306948-wkisfz1m	198	21	Staheli	Staheli	NNP
cord-306948-wkisfz1m	198	22	et	et	NNP
cord-306948-wkisfz1m	198	23	al	al	NNP
cord-306948-wkisfz1m	198	24	.	.	NNP
cord-306948-wkisfz1m	198	25	,	,	,
cord-306948-wkisfz1m	198	26	2007	2007	CD
cord-306948-wkisfz1m	198	27	;	;	:
cord-306948-wkisfz1m	198	28	Sun	Sun	NNP
cord-306948-wkisfz1m	198	29	et	et	NNP
cord-306948-wkisfz1m	198	30	al	al	NNP
cord-306948-wkisfz1m	198	31	.	.	.
cord-306948-wkisfz1m	199	1	,	,	,
cord-306948-wkisfz1m	199	2	2010a	2010a	NNP
cord-306948-wkisfz1m	199	3	Sun	Sun	NNP
cord-306948-wkisfz1m	199	4	et	et	FW
cord-306948-wkisfz1m	199	5	al	al	NNP
cord-306948-wkisfz1m	199	6	.	.	.
cord-306948-wkisfz1m	200	1	,	,	,
cord-306948-wkisfz1m	200	2	,	,	,
cord-306948-wkisfz1m	200	3	2012b	2012b	CD
cord-306948-wkisfz1m	200	4	van	van	NNP
cord-306948-wkisfz1m	200	5	Kasteren	Kasteren	NNP
cord-306948-wkisfz1m	200	6	et	et	NNP
cord-306948-wkisfz1m	200	7	al	al	NNP
cord-306948-wkisfz1m	200	8	.	.	NNP
cord-306948-wkisfz1m	200	9	,	,	,
cord-306948-wkisfz1m	200	10	2012	2012	CD
cord-306948-wkisfz1m	200	11	)	)	-RRB-
cord-306948-wkisfz1m	201	1	Besides	besides	IN
cord-306948-wkisfz1m	201	2	the	the	DT
cord-306948-wkisfz1m	201	3	proteinase	proteinase	NN
cord-306948-wkisfz1m	201	4	and	and	CC
cord-306948-wkisfz1m	201	5	deubiquitinase	deubiquitinase	NN
cord-306948-wkisfz1m	201	6	functions	function	NNS
cord-306948-wkisfz1m	201	7	,	,	,
cord-306948-wkisfz1m	201	8	nsp2	nsp2	NNP
cord-306948-wkisfz1m	201	9	contributes	contribute	VBZ
cord-306948-wkisfz1m	201	10	to	to	IN
cord-306948-wkisfz1m	201	11	the	the	DT
cord-306948-wkisfz1m	201	12	major	major	JJ
cord-306948-wkisfz1m	201	13	genetic	genetic	JJ
cord-306948-wkisfz1m	201	14	differences	difference	NNS
cord-306948-wkisfz1m	201	15	between	between	IN
cord-306948-wkisfz1m	201	16	genotypes	genotype	NNS
cord-306948-wkisfz1m	201	17	I	-PRON-	PRP
cord-306948-wkisfz1m	201	18	and	and	CC
cord-306948-wkisfz1m	201	19	II	II	NNP
cord-306948-wkisfz1m	201	20	,	,	,
cord-306948-wkisfz1m	201	21	sharing	share	VBG
cord-306948-wkisfz1m	201	22	only	only	RB
cord-306948-wkisfz1m	201	23	less	less	JJR
cord-306948-wkisfz1m	201	24	than	than	IN
cord-306948-wkisfz1m	201	25	40	40	CD
cord-306948-wkisfz1m	201	26	%	%	NN
cord-306948-wkisfz1m	201	27	similarity	similarity	NN
cord-306948-wkisfz1m	201	28	at	at	IN
cord-306948-wkisfz1m	201	29	the	the	DT
cord-306948-wkisfz1m	201	30	amino	amino	NN
cord-306948-wkisfz1m	201	31	acid	acid	NN
cord-306948-wkisfz1m	201	32	level	level	NN
cord-306948-wkisfz1m	201	33	(	(	-LRB-
cord-306948-wkisfz1m	201	34	Allende	Allende	NNP
cord-306948-wkisfz1m	201	35	et	et	NNP
cord-306948-wkisfz1m	201	36	al	al	NNP
cord-306948-wkisfz1m	201	37	.	.	NNP
cord-306948-wkisfz1m	201	38	,	,	,
cord-306948-wkisfz1m	201	39	1999	1999	CD
cord-306948-wkisfz1m	201	40	;	;	:
cord-306948-wkisfz1m	202	1	Nelsen	Nelsen	NNP
cord-306948-wkisfz1m	202	2	et	et	NNP
cord-306948-wkisfz1m	202	3	al	al	NNP
cord-306948-wkisfz1m	202	4	.	.	NNP
cord-306948-wkisfz1m	202	5	,	,	,
cord-306948-wkisfz1m	202	6	1999	1999	CD
cord-306948-wkisfz1m	202	7	)	)	-RRB-
cord-306948-wkisfz1m	202	8	.	.	.
cord-306948-wkisfz1m	203	1	The	the	DT
cord-306948-wkisfz1m	203	2	nsp2	nsp2	NNP
cord-306948-wkisfz1m	203	3	gene	gene	NN
cord-306948-wkisfz1m	203	4	also	also	RB
cord-306948-wkisfz1m	203	5	contains	contain	VBZ
cord-306948-wkisfz1m	203	6	naturally	naturally	RB
cord-306948-wkisfz1m	203	7	inserted	insert	VBN
cord-306948-wkisfz1m	203	8	sequences	sequence	NNS
cord-306948-wkisfz1m	203	9	and	and	CC
cord-306948-wkisfz1m	203	10	deletions	deletion	NNS
cord-306948-wkisfz1m	203	11	(	(	-LRB-
cord-306948-wkisfz1m	203	12	Fig	Fig	NNP
cord-306948-wkisfz1m	203	13	.	.	.
cord-306948-wkisfz1m	203	14	2A	2a	CD
cord-306948-wkisfz1m	203	15	)	)	-RRB-
cord-306948-wkisfz1m	203	16	in	in	IN
cord-306948-wkisfz1m	203	17	the	the	DT
cord-306948-wkisfz1m	203	18	hypervariable	hypervariable	JJ
cord-306948-wkisfz1m	203	19	region	region	NN
cord-306948-wkisfz1m	203	20	(	(	-LRB-
cord-306948-wkisfz1m	203	21	Fang	Fang	NNP
cord-306948-wkisfz1m	203	22	et	et	FW
cord-306948-wkisfz1m	203	23	al	al	NNP
cord-306948-wkisfz1m	203	24	.	.	NNP
cord-306948-wkisfz1m	203	25	,	,	,
cord-306948-wkisfz1m	203	26	2004	2004	CD
cord-306948-wkisfz1m	203	27	;	;	:
cord-306948-wkisfz1m	203	28	Gao	Gao	NNP
cord-306948-wkisfz1m	203	29	et	et	NNP
cord-306948-wkisfz1m	203	30	al	al	NNP
cord-306948-wkisfz1m	203	31	.	.	NNP
cord-306948-wkisfz1m	203	32	,	,	,
cord-306948-wkisfz1m	203	33	2004	2004	CD
cord-306948-wkisfz1m	203	34	;	;	:
cord-306948-wkisfz1m	203	35	Ni	Ni	NNP
cord-306948-wkisfz1m	203	36	et	et	NNP
cord-306948-wkisfz1m	203	37	al	al	NNP
cord-306948-wkisfz1m	203	38	.	.	NNP
cord-306948-wkisfz1m	203	39	,	,	,
cord-306948-wkisfz1m	203	40	2011	2011	CD
cord-306948-wkisfz1m	203	41	;	;	:
cord-306948-wkisfz1m	203	42	Shen	Shen	NNP
cord-306948-wkisfz1m	203	43	et	et	NNP
cord-306948-wkisfz1m	203	44	al	al	NNP
cord-306948-wkisfz1m	203	45	.	.	NNP
cord-306948-wkisfz1m	203	46	,	,	,
cord-306948-wkisfz1m	203	47	2000	2000	CD
cord-306948-wkisfz1m	203	48	;	;	:
cord-306948-wkisfz1m	203	49	Tian	Tian	NNP
cord-306948-wkisfz1m	203	50	et	et	NNP
cord-306948-wkisfz1m	203	51	al	al	NNP
cord-306948-wkisfz1m	203	52	.	.	NNP
cord-306948-wkisfz1m	203	53	,	,	,
cord-306948-wkisfz1m	203	54	2007	2007	CD
cord-306948-wkisfz1m	203	55	)	)	-RRB-
cord-306948-wkisfz1m	203	56	.	.	.
cord-306948-wkisfz1m	204	1	The	the	DT
cord-306948-wkisfz1m	204	2	deletion	deletion	NN
cord-306948-wkisfz1m	204	3	of	of	IN
cord-306948-wkisfz1m	204	4	12	12	CD
cord-306948-wkisfz1m	204	5	amino	amino	NN
cord-306948-wkisfz1m	204	6	acids	acid	NNS
cord-306948-wkisfz1m	204	7	in	in	IN
cord-306948-wkisfz1m	204	8	nsp2	nsp2	NNP
cord-306948-wkisfz1m	204	9	was	be	VBD
cord-306948-wkisfz1m	204	10	first	first	RB
cord-306948-wkisfz1m	204	11	found	find	VBN
cord-306948-wkisfz1m	204	12	in	in	IN
cord-306948-wkisfz1m	204	13	a	a	DT
cord-306948-wkisfz1m	204	14	Chinese	chinese	JJ
cord-306948-wkisfz1m	204	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	204	16	isolate	isolate	VBP
cord-306948-wkisfz1m	204	17	,	,	,
cord-306948-wkisfz1m	204	18	HB-2(sh)/2002	hb-2(sh)/2002	UH
cord-306948-wkisfz1m	204	19	,	,	,
cord-306948-wkisfz1m	204	20	in	in	IN
cord-306948-wkisfz1m	204	21	comparison	comparison	NN
cord-306948-wkisfz1m	204	22	with	with	IN
cord-306948-wkisfz1m	204	23	other	other	JJ
cord-306948-wkisfz1m	204	24	North	north	JJ
cord-306948-wkisfz1m	204	25	American	american	JJ
cord-306948-wkisfz1m	204	26	isolates	isolate	NNS
cord-306948-wkisfz1m	204	27	(	(	-LRB-
cord-306948-wkisfz1m	204	28	Gao	Gao	NNP
cord-306948-wkisfz1m	204	29	et	et	NNP
cord-306948-wkisfz1m	204	30	al	al	NNP
cord-306948-wkisfz1m	204	31	.	.	NNP
cord-306948-wkisfz1m	204	32	,	,	,
cord-306948-wkisfz1m	204	33	2004	2004	CD
cord-306948-wkisfz1m	204	34	)	)	-RRB-
cord-306948-wkisfz1m	204	35	.	.	.
cord-306948-wkisfz1m	205	1	Sequence	sequence	NN
cord-306948-wkisfz1m	205	2	analysis	analysis	NN
cord-306948-wkisfz1m	205	3	of	of	IN
cord-306948-wkisfz1m	205	4	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	205	5	MN184	MN184	NNP
cord-306948-wkisfz1m	205	6	reveals	reveal	VBZ
cord-306948-wkisfz1m	205	7	three	three	CD
cord-306948-wkisfz1m	205	8	discontinuous	discontinuous	JJ
cord-306948-wkisfz1m	205	9	deletions	deletion	NNS
cord-306948-wkisfz1m	205	10	of	of	IN
cord-306948-wkisfz1m	205	11	111	111	CD
cord-306948-wkisfz1m	205	12	,	,	,
cord-306948-wkisfz1m	205	13	1	1	CD
cord-306948-wkisfz1m	205	14	,	,	,
cord-306948-wkisfz1m	205	15	and	and	CC
cord-306948-wkisfz1m	205	16	19	19	CD
cord-306948-wkisfz1m	205	17	amino	amino	JJ
cord-306948-wkisfz1m	205	18	acids	acid	NNS
cord-306948-wkisfz1m	205	19	at	at	IN
cord-306948-wkisfz1m	205	20	the	the	DT
cord-306948-wkisfz1m	205	21	corresponding	correspond	VBG
cord-306948-wkisfz1m	205	22	positions	position	NNS
cord-306948-wkisfz1m	205	23	324	324	CD
cord-306948-wkisfz1m	205	24	-	-	SYM
cord-306948-wkisfz1m	205	25	434	434	CD
cord-306948-wkisfz1m	205	26	,	,	,
cord-306948-wkisfz1m	205	27	486	486	CD
cord-306948-wkisfz1m	205	28	,	,	,
cord-306948-wkisfz1m	205	29	and	and	CC
cord-306948-wkisfz1m	205	30	505	505	CD
cord-306948-wkisfz1m	205	31	-	-	SYM
cord-306948-wkisfz1m	205	32	523	523	CD
cord-306948-wkisfz1m	205	33	of	of	IN
cord-306948-wkisfz1m	205	34	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	205	35	,	,	,
cord-306948-wkisfz1m	205	36	respectively	respectively	RB
cord-306948-wkisfz1m	205	37	(	(	-LRB-
cord-306948-wkisfz1m	205	38	Han	Han	NNP
cord-306948-wkisfz1m	205	39	et	et	NNP
cord-306948-wkisfz1m	205	40	al	al	NNP
cord-306948-wkisfz1m	205	41	.	.	NNP
cord-306948-wkisfz1m	205	42	,	,	,
cord-306948-wkisfz1m	205	43	2006	2006	CD
cord-306948-wkisfz1m	205	44	)	)	-RRB-
cord-306948-wkisfz1m	205	45	.	.	.
cord-306948-wkisfz1m	206	1	Discontinuous	discontinuous	JJ
cord-306948-wkisfz1m	206	2	deletions	deletion	NNS
cord-306948-wkisfz1m	206	3	were	be	VBD
cord-306948-wkisfz1m	206	4	also	also	RB
cord-306948-wkisfz1m	206	5	identified	identify	VBN
cord-306948-wkisfz1m	206	6	in	in	IN
cord-306948-wkisfz1m	206	7	the	the	DT
cord-306948-wkisfz1m	206	8	highly	highly	RB
cord-306948-wkisfz1m	206	9	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	206	10	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	206	11	(	(	-LRB-
cord-306948-wkisfz1m	206	12	HP	HP	NNP
cord-306948-wkisfz1m	206	13	-	-	HYPH
cord-306948-wkisfz1m	206	14	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	206	15	)	)	-RRB-
cord-306948-wkisfz1m	206	16	associated	associate	VBD
cord-306948-wkisfz1m	206	17	with	with	IN
cord-306948-wkisfz1m	206	18	the	the	DT
cord-306948-wkisfz1m	206	19	2006	2006	CD
cord-306948-wkisfz1m	206	20	outbreaks	outbreak	NNS
cord-306948-wkisfz1m	206	21	of	of	IN
cord-306948-wkisfz1m	206	22	porcine	porcine	JJ
cord-306948-wkisfz1m	206	23	high	high	JJ
cord-306948-wkisfz1m	206	24	fever	fever	NN
cord-306948-wkisfz1m	206	25	disease	disease	NN
cord-306948-wkisfz1m	206	26	in	in	IN
cord-306948-wkisfz1m	206	27	China	China	NNP
cord-306948-wkisfz1m	206	28	(	(	-LRB-
cord-306948-wkisfz1m	206	29	Tian	Tian	NNP
cord-306948-wkisfz1m	206	30	et	et	FW
cord-306948-wkisfz1m	206	31	al	al	NNP
cord-306948-wkisfz1m	206	32	.	.	NNP
cord-306948-wkisfz1m	206	33	,	,	,
cord-306948-wkisfz1m	206	34	2007	2007	CD
cord-306948-wkisfz1m	206	35	)	)	-RRB-
cord-306948-wkisfz1m	206	36	.	.	.
cord-306948-wkisfz1m	207	1	The	the	DT
cord-306948-wkisfz1m	207	2	30	30	CD
cord-306948-wkisfz1m	207	3	amino	amino	NN
cord-306948-wkisfz1m	207	4	acids	acid	NNS
cord-306948-wkisfz1m	207	5	discontinuous	discontinuous	JJ
cord-306948-wkisfz1m	207	6	deletion	deletion	NN
cord-306948-wkisfz1m	207	7	consists	consist	VBZ
cord-306948-wkisfz1m	207	8	of	of	IN
cord-306948-wkisfz1m	207	9	1	1	CD
cord-306948-wkisfz1m	207	10	aa	aa	NNP
cord-306948-wkisfz1m	207	11	deletion	deletion	NN
cord-306948-wkisfz1m	207	12	at	at	IN
cord-306948-wkisfz1m	207	13	position	position	NN
cord-306948-wkisfz1m	207	14	482	482	CD
cord-306948-wkisfz1m	207	15	and	and	CC
cord-306948-wkisfz1m	207	16	29	29	CD
cord-306948-wkisfz1m	207	17	aa	aa	NNP
cord-306948-wkisfz1m	207	18	deletions	deletion	NNS
cord-306948-wkisfz1m	207	19	at	at	IN
cord-306948-wkisfz1m	207	20	534	534	CD
cord-306948-wkisfz1m	207	21	-	-	SYM
cord-306948-wkisfz1m	207	22	562	562	CD
cord-306948-wkisfz1m	207	23	,	,	,
cord-306948-wkisfz1m	207	24	and	and	CC
cord-306948-wkisfz1m	207	25	the	the	DT
cord-306948-wkisfz1m	207	26	deletion	deletion	NN
cord-306948-wkisfz1m	207	27	region	region	NN
cord-306948-wkisfz1m	207	28	contains	contain	VBZ
cord-306948-wkisfz1m	207	29	Bcell	Bcell	NNP
cord-306948-wkisfz1m	207	30	epitopes	epitope	NNS
cord-306948-wkisfz1m	207	31	(	(	-LRB-
cord-306948-wkisfz1m	207	32	de	de	FW
cord-306948-wkisfz1m	207	33	Lima	Lima	NNP
cord-306948-wkisfz1m	207	34	et	et	NNP
cord-306948-wkisfz1m	207	35	al	al	NNP
cord-306948-wkisfz1m	207	36	.	.	NNP
cord-306948-wkisfz1m	207	37	,	,	,
cord-306948-wkisfz1m	207	38	2006	2006	CD
cord-306948-wkisfz1m	207	39	)	)	-RRB-
cord-306948-wkisfz1m	207	40	and	and	CC
cord-306948-wkisfz1m	207	41	T	t	NN
cord-306948-wkisfz1m	207	42	-	-	HYPH
cord-306948-wkisfz1m	207	43	cell	cell	NN
cord-306948-wkisfz1m	207	44	epitopes	epitope	NNS
cord-306948-wkisfz1m	207	45	(	(	-LRB-
cord-306948-wkisfz1m	207	46	Chen	Chen	NNP
cord-306948-wkisfz1m	207	47	et	et	NNP
cord-306948-wkisfz1m	207	48	al	al	NNP
cord-306948-wkisfz1m	207	49	.	.	NNP
cord-306948-wkisfz1m	207	50	,	,	,
cord-306948-wkisfz1m	207	51	2010b	2010b	CD
cord-306948-wkisfz1m	207	52	)	)	-RRB-
cord-306948-wkisfz1m	207	53	.	.	.
cord-306948-wkisfz1m	208	1	Strikingly	strikingly	RB
cord-306948-wkisfz1m	208	2	,	,	,
cord-306948-wkisfz1m	208	3	cell	cell	NN
cord-306948-wkisfz1m	208	4	culture	culture	NN
cord-306948-wkisfz1m	208	5	passages	passage	NNS
cord-306948-wkisfz1m	208	6	of	of	IN
cord-306948-wkisfz1m	208	7	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	208	8	may	may	MD
cord-306948-wkisfz1m	208	9	generate	generate	VB
cord-306948-wkisfz1m	208	10	a	a	DT
cord-306948-wkisfz1m	208	11	deletion	deletion	NN
cord-306948-wkisfz1m	208	12	in	in	IN
cord-306948-wkisfz1m	208	13	nsp2	nsp2	NNP
cord-306948-wkisfz1m	208	14	,	,	,
cord-306948-wkisfz1m	208	15	and	and	CC
cord-306948-wkisfz1m	208	16	a	a	DT
cord-306948-wkisfz1m	208	17	study	study	NN
cord-306948-wkisfz1m	208	18	shows	show	VBZ
cord-306948-wkisfz1m	208	19	the	the	DT
cord-306948-wkisfz1m	208	20	generation	generation	NN
cord-306948-wkisfz1m	208	21	of	of	IN
cord-306948-wkisfz1m	208	22	a	a	DT
cord-306948-wkisfz1m	208	23	large	large	JJ
cord-306948-wkisfz1m	208	24	deletion	deletion	NN
cord-306948-wkisfz1m	208	25	of	of	IN
cord-306948-wkisfz1m	208	26	135	135	CD
cord-306948-wkisfz1m	208	27	aa	aa	NN
cord-306948-wkisfz1m	208	28	at	at	IN
cord-306948-wkisfz1m	208	29	581	581	CD
cord-306948-wkisfz1m	208	30	-	-	SYM
cord-306948-wkisfz1m	208	31	725	725	CD
cord-306948-wkisfz1m	208	32	in	in	IN
cord-306948-wkisfz1m	208	33	nsp2	nsp2	NN
cord-306948-wkisfz1m	208	34	during	during	IN
cord-306948-wkisfz1m	208	35	passages	passage	NNS
cord-306948-wkisfz1m	208	36	(	(	-LRB-
cord-306948-wkisfz1m	208	37	Ni	Ni	NNP
cord-306948-wkisfz1m	208	38	et	et	NNP
cord-306948-wkisfz1m	208	39	al	al	NNP
cord-306948-wkisfz1m	208	40	.	.	NNP
cord-306948-wkisfz1m	208	41	,	,	,
cord-306948-wkisfz1m	208	42	2011	2011	CD
cord-306948-wkisfz1m	208	43	)	)	-RRB-
cord-306948-wkisfz1m	208	44	.	.	.
cord-306948-wkisfz1m	209	1	A	a	DT
cord-306948-wkisfz1m	209	2	deletion	deletion	NN
cord-306948-wkisfz1m	209	3	in	in	IN
cord-306948-wkisfz1m	209	4	nsp2	nsp2	NN
cord-306948-wkisfz1m	209	5	is	be	VBZ
cord-306948-wkisfz1m	209	6	also	also	RB
cord-306948-wkisfz1m	209	7	found	find	VBN
cord-306948-wkisfz1m	209	8	in	in	IN
cord-306948-wkisfz1m	209	9	genotype	genotype	NN
cord-306948-wkisfz1m	209	10	I	-PRON-	PRP
cord-306948-wkisfz1m	209	11	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	209	12	.	.	.
cord-306948-wkisfz1m	210	1	The	the	DT
cord-306948-wkisfz1m	210	2	EuroPRRS	EuroPRRS	NNP
cord-306948-wkisfz1m	210	3	SD-01	SD-01	NNP
cord-306948-wkisfz1m	210	4	-	-	HYPH
cord-306948-wkisfz1m	210	5	08	08	CD
cord-306948-wkisfz1m	210	6	virus	virus	NN
cord-306948-wkisfz1m	210	7	in	in	IN
cord-306948-wkisfz1m	210	8	the	the	DT
cord-306948-wkisfz1m	210	9	US	US	NNP
cord-306948-wkisfz1m	210	10	shows	show	VBZ
cord-306948-wkisfz1m	210	11	a	a	DT
cord-306948-wkisfz1m	210	12	17	17	CD
cord-306948-wkisfz1m	210	13	aa	aa	NNP
cord-306948-wkisfz1m	210	14	deletion	deletion	NN
cord-306948-wkisfz1m	210	15	at	at	IN
cord-306948-wkisfz1m	210	16	positions	position	NNS
cord-306948-wkisfz1m	210	17	349	349	CD
cord-306948-wkisfz1m	210	18	-	-	SYM
cord-306948-wkisfz1m	210	19	365	365	CD
cord-306948-wkisfz1m	210	20	of	of	IN
cord-306948-wkisfz1m	210	21	nsp2	nsp2	NN
cord-306948-wkisfz1m	210	22	when	when	WRB
cord-306948-wkisfz1m	210	23	compared	compare	VBN
cord-306948-wkisfz1m	210	24	to	to	IN
cord-306948-wkisfz1m	210	25	Lelystad	Lelystad	NNP
cord-306948-wkisfz1m	210	26	virus	virus	NN
cord-306948-wkisfz1m	210	27	(	(	-LRB-
cord-306948-wkisfz1m	210	28	Fang	Fang	NNP
cord-306948-wkisfz1m	210	29	et	et	FW
cord-306948-wkisfz1m	210	30	al	al	NNP
cord-306948-wkisfz1m	210	31	.	.	NNP
cord-306948-wkisfz1m	210	32	,	,	,
cord-306948-wkisfz1m	210	33	2004	2004	CD
cord-306948-wkisfz1m	210	34	)	)	-RRB-
cord-306948-wkisfz1m	210	35	.	.	.
cord-306948-wkisfz1m	211	1	Biological	biological	JJ
cord-306948-wkisfz1m	211	2	significance	significance	NN
cord-306948-wkisfz1m	211	3	of	of	IN
cord-306948-wkisfz1m	211	4	the	the	DT
cord-306948-wkisfz1m	211	5	genetic	genetic	JJ
cord-306948-wkisfz1m	211	6	deletion	deletion	NN
cord-306948-wkisfz1m	211	7	in	in	IN
cord-306948-wkisfz1m	211	8	nsp2	nsp2	NNP
cord-306948-wkisfz1m	211	9	remains	remain	VBZ
cord-306948-wkisfz1m	211	10	to	to	TO
cord-306948-wkisfz1m	211	11	be	be	VB
cord-306948-wkisfz1m	211	12	determined	determine	VBN
cord-306948-wkisfz1m	211	13	.	.	.
cord-306948-wkisfz1m	212	1	Besides	besides	IN
cord-306948-wkisfz1m	212	2	deletions	deletion	NNS
cord-306948-wkisfz1m	212	3	,	,	,
cord-306948-wkisfz1m	212	4	a	a	DT
cord-306948-wkisfz1m	212	5	36	36	CD
cord-306948-wkisfz1m	212	6	aa	aa	NN
cord-306948-wkisfz1m	212	7	insertion	insertion	NN
cord-306948-wkisfz1m	212	8	was	be	VBD
cord-306948-wkisfz1m	212	9	also	also	RB
cord-306948-wkisfz1m	212	10	observed	observe	VBN
cord-306948-wkisfz1m	212	11	in	in	IN
cord-306948-wkisfz1m	212	12	the	the	DT
cord-306948-wkisfz1m	212	13	SP	SP	NNP
cord-306948-wkisfz1m	212	14	strain	strain	NN
cord-306948-wkisfz1m	212	15	of	of	IN
cord-306948-wkisfz1m	212	16	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	212	17	,	,	,
cord-306948-wkisfz1m	212	18	which	which	WDT
cord-306948-wkisfz1m	212	19	is	be	VBZ
cord-306948-wkisfz1m	212	20	a	a	DT
cord-306948-wkisfz1m	212	21	vaccine	vaccine	NN
cord-306948-wkisfz1m	212	22	strain	strain	NN
cord-306948-wkisfz1m	212	23	,	,	,
cord-306948-wkisfz1m	212	24	located	locate	VBN
cord-306948-wkisfz1m	212	25	between	between	IN
cord-306948-wkisfz1m	212	26	G812	G812	NNP
cord-306948-wkisfz1m	212	27	and	and	CC
cord-306948-wkisfz1m	212	28	T849	t849	CD
cord-306948-wkisfz1m	212	29	of	of	IN
cord-306948-wkisfz1m	212	30	the	the	DT
cord-306948-wkisfz1m	212	31	SP	SP	NNP
cord-306948-wkisfz1m	212	32	nsp2	nsp2	NNP
cord-306948-wkisfz1m	212	33	(	(	-LRB-
cord-306948-wkisfz1m	212	34	Shen	Shen	NNP
cord-306948-wkisfz1m	212	35	et	et	NNP
cord-306948-wkisfz1m	212	36	al	al	NNP
cord-306948-wkisfz1m	212	37	.	.	NNP
cord-306948-wkisfz1m	212	38	,	,	,
cord-306948-wkisfz1m	212	39	2000	2000	CD
cord-306948-wkisfz1m	212	40	)	)	-RRB-
cord-306948-wkisfz1m	212	41	.	.	.
cord-306948-wkisfz1m	213	1	Given	give	VBN
cord-306948-wkisfz1m	213	2	the	the	DT
cord-306948-wkisfz1m	213	3	tolerance	tolerance	NN
cord-306948-wkisfz1m	213	4	of	of	IN
cord-306948-wkisfz1m	213	5	deletions	deletion	NNS
cord-306948-wkisfz1m	213	6	and	and	CC
cord-306948-wkisfz1m	213	7	insertions	insertion	NNS
cord-306948-wkisfz1m	213	8	in	in	IN
cord-306948-wkisfz1m	213	9	the	the	DT
cord-306948-wkisfz1m	213	10	hypervirable	hypervirable	JJ
cord-306948-wkisfz1m	213	11	region	region	NN
cord-306948-wkisfz1m	213	12	of	of	IN
cord-306948-wkisfz1m	213	13	nsp2	nsp2	NNP
cord-306948-wkisfz1m	213	14	,	,	,
cord-306948-wkisfz1m	213	15	this	this	DT
cord-306948-wkisfz1m	213	16	region	region	NN
cord-306948-wkisfz1m	213	17	is	be	VBZ
cord-306948-wkisfz1m	213	18	considered	consider	VBN
cord-306948-wkisfz1m	213	19	as	as	IN
cord-306948-wkisfz1m	213	20	a	a	DT
cord-306948-wkisfz1m	213	21	site	site	NN
cord-306948-wkisfz1m	213	22	for	for	IN
cord-306948-wkisfz1m	213	23	foreign	foreign	JJ
cord-306948-wkisfz1m	213	24	gene	gene	NN
cord-306948-wkisfz1m	213	25	insertion	insertion	NN
cord-306948-wkisfz1m	213	26	(	(	-LRB-
cord-306948-wkisfz1m	213	27	Fig	Fig	NNP
cord-306948-wkisfz1m	213	28	.	.	.
cord-306948-wkisfz1m	213	29	2B	2B	NNP
cord-306948-wkisfz1m	213	30	and	and	CC
cord-306948-wkisfz1m	213	31	C	C	NNP
cord-306948-wkisfz1m	213	32	)	)	-RRB-
cord-306948-wkisfz1m	213	33	.	.	.
cord-306948-wkisfz1m	214	1	The	the	DT
cord-306948-wkisfz1m	214	2	GFP	GFP	NNP
cord-306948-wkisfz1m	214	3	gene	gene	NN
cord-306948-wkisfz1m	214	4	was	be	VBD
cord-306948-wkisfz1m	214	5	inserted	insert	VBN
cord-306948-wkisfz1m	214	6	into	into	IN
cord-306948-wkisfz1m	214	7	nsp2	nsp2	NN
cord-306948-wkisfz1m	214	8	of	of	IN
cord-306948-wkisfz1m	214	9	the	the	DT
cord-306948-wkisfz1m	214	10	SD01	SD01	NNP
cord-306948-wkisfz1m	214	11	-	-	HYPH
cord-306948-wkisfz1m	214	12	08	08	CD
cord-306948-wkisfz1m	214	13	strain	strain	NN
cord-306948-wkisfz1m	214	14	and	and	CC
cord-306948-wkisfz1m	214	15	fully	fully	RB
cord-306948-wkisfz1m	214	16	infectious	infectious	JJ
cord-306948-wkisfz1m	214	17	virus	virus	NN
cord-306948-wkisfz1m	214	18	was	be	VBD
cord-306948-wkisfz1m	214	19	rescued	rescue	VBN
cord-306948-wkisfz1m	214	20	(	(	-LRB-
cord-306948-wkisfz1m	214	21	Fang	Fang	NNP
cord-306948-wkisfz1m	214	22	et	et	FW
cord-306948-wkisfz1m	214	23	al	al	NNP
cord-306948-wkisfz1m	214	24	.	.	NNP
cord-306948-wkisfz1m	214	25	,	,	,
cord-306948-wkisfz1m	214	26	2006b	2006b	CD
cord-306948-wkisfz1m	214	27	)	)	-RRB-
cord-306948-wkisfz1m	214	28	.	.	.
cord-306948-wkisfz1m	215	1	The	the	DT
cord-306948-wkisfz1m	215	2	GFP	GFP	NNP
cord-306948-wkisfz1m	215	3	insertion	insertion	NN
cord-306948-wkisfz1m	215	4	did	do	VBD
cord-306948-wkisfz1m	215	5	not	not	RB
cord-306948-wkisfz1m	215	6	affect	affect	VB
cord-306948-wkisfz1m	215	7	the	the	DT
cord-306948-wkisfz1m	215	8	growth	growth	NN
cord-306948-wkisfz1m	215	9	of	of	IN
cord-306948-wkisfz1m	215	10	the	the	DT
cord-306948-wkisfz1m	215	11	virus	virus	NN
cord-306948-wkisfz1m	215	12	,	,	,
cord-306948-wkisfz1m	215	13	and	and	CC
cord-306948-wkisfz1m	215	14	the	the	DT
cord-306948-wkisfz1m	215	15	infectivity	infectivity	NN
cord-306948-wkisfz1m	215	16	was	be	VBD
cord-306948-wkisfz1m	215	17	comparable	comparable	JJ
cord-306948-wkisfz1m	215	18	to	to	IN
cord-306948-wkisfz1m	215	19	that	that	DT
cord-306948-wkisfz1m	215	20	of	of	IN
cord-306948-wkisfz1m	215	21	parental	parental	JJ
cord-306948-wkisfz1m	215	22	virus	virus	NN
cord-306948-wkisfz1m	215	23	.	.	.
cord-306948-wkisfz1m	216	1	The	the	DT
cord-306948-wkisfz1m	216	2	capacity	capacity	NN
cord-306948-wkisfz1m	216	3	of	of	IN
cord-306948-wkisfz1m	216	4	deletion	deletion	NN
cord-306948-wkisfz1m	216	5	in	in	IN
cord-306948-wkisfz1m	216	6	nsp2	nsp2	NNP
cord-306948-wkisfz1m	216	7	was	be	VBD
cord-306948-wkisfz1m	216	8	determined	determine	VBN
cord-306948-wkisfz1m	216	9	by	by	IN
cord-306948-wkisfz1m	216	10	introducing	introduce	VBG
cord-306948-wkisfz1m	216	11	a	a	DT
cord-306948-wkisfz1m	216	12	series	series	NN
cord-306948-wkisfz1m	216	13	of	of	IN
cord-306948-wkisfz1m	216	14	in	in	IN
cord-306948-wkisfz1m	216	15	-	-	HYPH
cord-306948-wkisfz1m	216	16	frame	frame	NN
cord-306948-wkisfz1m	216	17	deletions	deletion	NNS
cord-306948-wkisfz1m	216	18	(	(	-LRB-
cord-306948-wkisfz1m	216	19	Han	Han	NNP
cord-306948-wkisfz1m	216	20	et	et	NNP
cord-306948-wkisfz1m	216	21	al	al	NNP
cord-306948-wkisfz1m	216	22	.	.	NNP
cord-306948-wkisfz1m	216	23	,	,	,
cord-306948-wkisfz1m	216	24	2007	2007	CD
cord-306948-wkisfz1m	216	25	)	)	-RRB-
cord-306948-wkisfz1m	216	26	.	.	.
cord-306948-wkisfz1m	217	1	The	the	DT
cord-306948-wkisfz1m	217	2	PLP2	PLP2	NNP
cord-306948-wkisfz1m	217	3	domain	domain	NN
cord-306948-wkisfz1m	217	4	,	,	,
cord-306948-wkisfz1m	217	5	the	the	DT
cord-306948-wkisfz1m	217	6	PLP2	PLP2	NNP
cord-306948-wkisfz1m	217	7	downstream	downstream	NN
cord-306948-wkisfz1m	217	8	flanking	flank	VBG
cord-306948-wkisfz1m	217	9	region	region	NN
cord-306948-wkisfz1m	217	10	,	,	,
cord-306948-wkisfz1m	217	11	and	and	CC
cord-306948-wkisfz1m	217	12	the	the	DT
cord-306948-wkisfz1m	217	13	transmembrane	transmembrane	NN
cord-306948-wkisfz1m	217	14	domain	domain	NN
cord-306948-wkisfz1m	217	15	were	be	VBD
cord-306948-wkisfz1m	217	16	crucial	crucial	JJ
cord-306948-wkisfz1m	217	17	for	for	IN
cord-306948-wkisfz1m	217	18	virus	virus	NN
cord-306948-wkisfz1m	217	19	replication	replication	NN
cord-306948-wkisfz1m	217	20	but	but	CC
cord-306948-wkisfz1m	217	21	deletions	deletion	NNS
cord-306948-wkisfz1m	217	22	of	of	IN
cord-306948-wkisfz1m	217	23	13	13	CD
cord-306948-wkisfz1m	217	24	-	-	SYM
cord-306948-wkisfz1m	217	25	35	35	CD
cord-306948-wkisfz1m	217	26	aa	aa	NN
cord-306948-wkisfz1m	217	27	from	from	IN
cord-306948-wkisfz1m	217	28	the	the	DT
cord-306948-wkisfz1m	217	29	N	n	CD
cord-306948-wkisfz1m	217	30	-	-	HYPH
cord-306948-wkisfz1m	217	31	terminal	terminal	JJ
cord-306948-wkisfz1m	217	32	portion	portion	NN
cord-306948-wkisfz1m	217	33	of	of	IN
cord-306948-wkisfz1m	217	34	the	the	DT
cord-306948-wkisfz1m	217	35	hypervariable	hypervariable	JJ
cord-306948-wkisfz1m	217	36	region	region	NN
cord-306948-wkisfz1m	217	37	and	and	CC
cord-306948-wkisfz1m	217	38	324	324	CD
cord-306948-wkisfz1m	217	39	-	-	SYM
cord-306948-wkisfz1m	217	40	813	813	CD
cord-306948-wkisfz1m	217	41	aa	aa	NN
cord-306948-wkisfz1m	217	42	from	from	IN
cord-306948-wkisfz1m	217	43	the	the	DT
cord-306948-wkisfz1m	217	44	hypervariable	hypervariable	JJ
cord-306948-wkisfz1m	217	45	region	region	NN
cord-306948-wkisfz1m	217	46	appeared	appear	VBD
cord-306948-wkisfz1m	217	47	to	to	TO
cord-306948-wkisfz1m	217	48	be	be	VB
cord-306948-wkisfz1m	217	49	tolerable	tolerable	JJ
cord-306948-wkisfz1m	217	50	for	for	IN
cord-306948-wkisfz1m	217	51	viability	viability	NN
cord-306948-wkisfz1m	217	52	.	.	.
cord-306948-wkisfz1m	218	1	In	in	IN
cord-306948-wkisfz1m	218	2	the	the	DT
cord-306948-wkisfz1m	218	3	hypervariable	hypervariable	JJ
cord-306948-wkisfz1m	218	4	region	region	NN
cord-306948-wkisfz1m	218	5	,	,	,
cord-306948-wkisfz1m	218	6	the	the	DT
cord-306948-wkisfz1m	218	7	largest	large	JJS
cord-306948-wkisfz1m	218	8	deletion	deletion	NN
cord-306948-wkisfz1m	218	9	that	that	WDT
cord-306948-wkisfz1m	218	10	can	can	MD
cord-306948-wkisfz1m	218	11	be	be	VB
cord-306948-wkisfz1m	218	12	achieved	achieve	VBN
cord-306948-wkisfz1m	218	13	was	be	VBD
cord-306948-wkisfz1m	218	14	about	about	RB
cord-306948-wkisfz1m	218	15	400	400	CD
cord-306948-wkisfz1m	218	16	aa	aa	NNP
cord-306948-wkisfz1m	218	17	at	at	IN
cord-306948-wkisfz1m	218	18	positions	position	NNS
cord-306948-wkisfz1m	218	19	324	324	CD
cord-306948-wkisfz1m	218	20	-	-	SYM
cord-306948-wkisfz1m	218	21	726	726	CD
cord-306948-wkisfz1m	218	22	,	,	,
cord-306948-wkisfz1m	218	23	although	although	IN
cord-306948-wkisfz1m	218	24	a	a	DT
cord-306948-wkisfz1m	218	25	deletion	deletion	NN
cord-306948-wkisfz1m	218	26	of	of	IN
cord-306948-wkisfz1m	218	27	up	up	IN
cord-306948-wkisfz1m	218	28	to	to	TO
cord-306948-wkisfz1m	218	29	200	200	CD
cord-306948-wkisfz1m	218	30	aa	aa	NNP
cord-306948-wkisfz1m	218	31	is	be	VBZ
cord-306948-wkisfz1m	218	32	preferable	preferable	JJ
cord-306948-wkisfz1m	218	33	for	for	IN
cord-306948-wkisfz1m	218	34	infectivity	infectivity	NN
cord-306948-wkisfz1m	218	35	(	(	-LRB-
cord-306948-wkisfz1m	218	36	Fig	Fig	NNP
cord-306948-wkisfz1m	218	37	.	.	.
cord-306948-wkisfz1m	218	38	2B	2b	CD
cord-306948-wkisfz1m	218	39	)	)	-RRB-
cord-306948-wkisfz1m	218	40	.	.	.
cord-306948-wkisfz1m	219	1	The	the	DT
cord-306948-wkisfz1m	219	2	insertion	insertion	NN
cord-306948-wkisfz1m	219	3	of	of	IN
cord-306948-wkisfz1m	219	4	GFP	GFP	NNP
cord-306948-wkisfz1m	219	5	or	or	CC
cord-306948-wkisfz1m	219	6	other	other	JJ
cord-306948-wkisfz1m	219	7	genes	gene	NNS
cord-306948-wkisfz1m	219	8	such	such	JJ
cord-306948-wkisfz1m	219	9	as	as	IN
cord-306948-wkisfz1m	219	10	New	New	NNP
cord-306948-wkisfz1m	219	11	Castle	Castle	NNP
cord-306948-wkisfz1m	219	12	disease	disease	NN
cord-306948-wkisfz1m	219	13	virus	virus	NN
cord-306948-wkisfz1m	219	14	nucleoprotein	nucleoprotein	NNP
cord-306948-wkisfz1m	219	15	(	(	-LRB-
cord-306948-wkisfz1m	219	16	NP	NP	NNP
cord-306948-wkisfz1m	219	17	)	)	-RRB-
cord-306948-wkisfz1m	219	18	gene	gene	NN
cord-306948-wkisfz1m	219	19	has	have	VBZ
cord-306948-wkisfz1m	219	20	been	be	VBN
cord-306948-wkisfz1m	219	21	successful	successful	JJ
cord-306948-wkisfz1m	219	22	as	as	RB
cord-306948-wkisfz1m	219	23	long	long	RB
cord-306948-wkisfz1m	219	24	as	as	IN
cord-306948-wkisfz1m	219	25	insertions	insertion	NNS
cord-306948-wkisfz1m	219	26	reside	reside	VBP
cord-306948-wkisfz1m	219	27	in	in	IN
cord-306948-wkisfz1m	219	28	the	the	DT
cord-306948-wkisfz1m	219	29	hypervirable	hypervirable	JJ
cord-306948-wkisfz1m	219	30	regions	region	NNS
cord-306948-wkisfz1m	219	31	(	(	-LRB-
cord-306948-wkisfz1m	219	32	Fig	Fig	NNP
cord-306948-wkisfz1m	219	33	.	.	.
cord-306948-wkisfz1m	219	34	2C	2C	NNP
cord-306948-wkisfz1m	219	35	)	)	-RRB-
cord-306948-wkisfz1m	220	1	(	(	-LRB-
cord-306948-wkisfz1m	220	2	Kim	Kim	NNP
cord-306948-wkisfz1m	220	3	et	et	NNP
cord-306948-wkisfz1m	220	4	al	al	NNP
cord-306948-wkisfz1m	220	5	.	.	NNP
cord-306948-wkisfz1m	220	6	,	,	,
cord-306948-wkisfz1m	220	7	2007	2007	CD
cord-306948-wkisfz1m	221	1	;	;	:
cord-306948-wkisfz1m	221	2	Xu	Xu	NNP
cord-306948-wkisfz1m	221	3	et	et	NNP
cord-306948-wkisfz1m	221	4	al	al	NNP
cord-306948-wkisfz1m	221	5	.	.	NNP
cord-306948-wkisfz1m	221	6	,	,	,
cord-306948-wkisfz1m	221	7	2012a	2012a	CD
cord-306948-wkisfz1m	221	8	)	)	-RRB-
cord-306948-wkisfz1m	221	9	.	.	.
cord-306948-wkisfz1m	222	1	The	the	DT
cord-306948-wkisfz1m	222	2	deletion	deletion	NN
cord-306948-wkisfz1m	222	3	of	of	IN
cord-306948-wkisfz1m	222	4	inmmunodominant	inmmunodominant	JJ
cord-306948-wkisfz1m	222	5	linear	linear	NNP
cord-306948-wkisfz1m	222	6	B	b	NN
cord-306948-wkisfz1m	222	7	-	-	HYPH
cord-306948-wkisfz1m	222	8	cell	cell	NN
cord-306948-wkisfz1m	222	9	epitopes	epitope	NNS
cord-306948-wkisfz1m	222	10	(	(	-LRB-
cord-306948-wkisfz1m	222	11	ES2-ES7	ES2-ES7	NNP
cord-306948-wkisfz1m	222	12	)	)	-RRB-
cord-306948-wkisfz1m	222	13	were	be	VBD
cord-306948-wkisfz1m	222	14	attempted	attempt	VBN
cord-306948-wkisfz1m	222	15	;	;	:
cord-306948-wkisfz1m	222	16	deletion	deletion	NN
cord-306948-wkisfz1m	222	17	of	of	IN
cord-306948-wkisfz1m	222	18	ES3	es3	NN
cord-306948-wkisfz1m	222	19	,	,	,
cord-306948-wkisfz1m	222	20	ES4	ES4	NNP
cord-306948-wkisfz1m	222	21	,	,	,
cord-306948-wkisfz1m	222	22	or	or	CC
cord-306948-wkisfz1m	222	23	ES7	ES7	NNP
cord-306948-wkisfz1m	222	24	allowed	allow	VBD
cord-306948-wkisfz1m	222	25	the	the	DT
cord-306948-wkisfz1m	222	26	generation	generation	NN
cord-306948-wkisfz1m	222	27	of	of	IN
cord-306948-wkisfz1m	222	28	an	an	DT
cord-306948-wkisfz1m	222	29	infectious	infectious	JJ
cord-306948-wkisfz1m	222	30	virus	virus	NN
cord-306948-wkisfz1m	223	1	(	(	-LRB-
cord-306948-wkisfz1m	223	2	Chen	Chen	NNP
cord-306948-wkisfz1m	223	3	et	et	NNP
cord-306948-wkisfz1m	223	4	al	al	NNP
cord-306948-wkisfz1m	223	5	.	.	.
cord-306948-wkisfz1m	224	1	,	,	,
cord-306948-wkisfz1m	224	2	2010b	2010b	CD
cord-306948-wkisfz1m	224	3	;	;	:
cord-306948-wkisfz1m	225	1	Oleksiewicz	Oleksiewicz	NNP
cord-306948-wkisfz1m	225	2	et	et	NNP
cord-306948-wkisfz1m	225	3	al	al	NNP
cord-306948-wkisfz1m	225	4	.	.	NNP
cord-306948-wkisfz1m	225	5	,	,	,
cord-306948-wkisfz1m	225	6	2001	2001	CD
cord-306948-wkisfz1m	225	7	)	)	-RRB-
cord-306948-wkisfz1m	225	8	.	.	.
cord-306948-wkisfz1m	226	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	226	2	N	N	NNP
cord-306948-wkisfz1m	226	3	is	be	VBZ
cord-306948-wkisfz1m	226	4	a	a	DT
cord-306948-wkisfz1m	226	5	mutilfunctional	mutilfunctional	JJ
cord-306948-wkisfz1m	226	6	protein	protein	NN
cord-306948-wkisfz1m	226	7	.	.	.
cord-306948-wkisfz1m	227	1	The	the	DT
cord-306948-wkisfz1m	227	2	specific	specific	JJ
cord-306948-wkisfz1m	227	3	domains	domain	NNS
cord-306948-wkisfz1m	227	4	and	and	CC
cord-306948-wkisfz1m	227	5	residues	residue	NNS
cord-306948-wkisfz1m	227	6	critical	critical	JJ
cord-306948-wkisfz1m	227	7	for	for	IN
cord-306948-wkisfz1m	227	8	virus	virus	NN
cord-306948-wkisfz1m	227	9	replication	replication	NN
cord-306948-wkisfz1m	227	10	have	have	VBP
cord-306948-wkisfz1m	227	11	been	be	VBN
cord-306948-wkisfz1m	227	12	identified	identify	VBN
cord-306948-wkisfz1m	227	13	in	in	IN
cord-306948-wkisfz1m	227	14	N	N	NNP
cord-306948-wkisfz1m	227	15	(	(	-LRB-
cord-306948-wkisfz1m	227	16	Fig	Fig	NNP
cord-306948-wkisfz1m	227	17	.	.	.
cord-306948-wkisfz1m	227	18	3A	3A	NNP
cord-306948-wkisfz1m	227	19	)	)	-RRB-
cord-306948-wkisfz1m	227	20	.	.	.
cord-306948-wkisfz1m	228	1	The	the	DT
cord-306948-wkisfz1m	228	2	N	N	NNP
cord-306948-wkisfz1m	228	3	protein	protein	NN
cord-306948-wkisfz1m	228	4	is	be	VBZ
cord-306948-wkisfz1m	228	5	comprised	comprise	VBN
cord-306948-wkisfz1m	228	6	of	of	IN
cord-306948-wkisfz1m	228	7	123	123	CD
cord-306948-wkisfz1m	228	8	or	or	CC
cord-306948-wkisfz1m	228	9	128	128	CD
cord-306948-wkisfz1m	228	10	aa	aa	NN
cord-306948-wkisfz1m	228	11	for	for	IN
cord-306948-wkisfz1m	228	12	the	the	DT
cord-306948-wkisfz1m	228	13	North	north	JJ
cord-306948-wkisfz1m	228	14	American	american	JJ
cord-306948-wkisfz1m	228	15	and	and	CC
cord-306948-wkisfz1m	228	16	European	european	JJ
cord-306948-wkisfz1m	228	17	genotypes	genotype	NNS
cord-306948-wkisfz1m	228	18	,	,	,
cord-306948-wkisfz1m	228	19	respectively	respectively	RB
cord-306948-wkisfz1m	228	20	(	(	-LRB-
cord-306948-wkisfz1m	228	21	Music	Music	NNP
cord-306948-wkisfz1m	228	22	and	and	CC
cord-306948-wkisfz1m	228	23	Gagnon	Gagnon	NNP
cord-306948-wkisfz1m	228	24	,	,	,
cord-306948-wkisfz1m	228	25	2010	2010	CD
cord-306948-wkisfz1m	228	26	)	)	-RRB-
cord-306948-wkisfz1m	228	27	.	.	.
cord-306948-wkisfz1m	229	1	N	N	NNP
cord-306948-wkisfz1m	229	2	consists	consist	VBZ
cord-306948-wkisfz1m	229	3	of	of	IN
cord-306948-wkisfz1m	229	4	the	the	DT
cord-306948-wkisfz1m	229	5	N	n	CD
cord-306948-wkisfz1m	229	6	-	-	HYPH
cord-306948-wkisfz1m	229	7	terminal	terminal	NN
cord-306948-wkisfz1m	229	8	RNA	RNA	NNP
cord-306948-wkisfz1m	229	9	-	-	HYPH
cord-306948-wkisfz1m	229	10	binding	bind	VBG
cord-306948-wkisfz1m	229	11	domain	domain	NN
cord-306948-wkisfz1m	229	12	(	(	-LRB-
cord-306948-wkisfz1m	229	13	RBD	RBD	NNP
cord-306948-wkisfz1m	229	14	)	)	-RRB-
cord-306948-wkisfz1m	229	15	at	at	IN
cord-306948-wkisfz1m	229	16	positions	position	NNS
cord-306948-wkisfz1m	229	17	41	41	CD
cord-306948-wkisfz1m	229	18	-	-	SYM
cord-306948-wkisfz1m	229	19	47	47	CD
cord-306948-wkisfz1m	229	20	and	and	CC
cord-306948-wkisfz1m	229	21	the	the	DT
cord-306948-wkisfz1m	229	22	C	C	NNP
cord-306948-wkisfz1m	229	23	-	-	HYPH
cord-306948-wkisfz1m	229	24	terminal	terminal	NN
cord-306948-wkisfz1m	229	25	dimerization	dimerization	NN
cord-306948-wkisfz1m	229	26	domain	domain	NN
cord-306948-wkisfz1m	229	27	comprising	comprise	VBG
cord-306948-wkisfz1m	229	28	a	a	DT
cord-306948-wkisfz1m	229	29	four	four	CD
cord-306948-wkisfz1m	229	30	-	-	HYPH
cord-306948-wkisfz1m	229	31	stranded	strand	VBN
cord-306948-wkisfz1m	229	32	antiparallel	antiparallel	IN
cord-306948-wkisfz1m	229	33	b	b	NN
cord-306948-wkisfz1m	229	34	-	-	HYPH
cord-306948-wkisfz1m	229	35	sheet	sheet	NN
cord-306948-wkisfz1m	229	36	floor	floor	NN
cord-306948-wkisfz1m	229	37	flanked	flank	VBN
cord-306948-wkisfz1m	229	38	by	by	IN
cord-306948-wkisfz1m	229	39	a	a	DT
cord-306948-wkisfz1m	229	40	-	-	:
cord-306948-wkisfz1m	229	41	helices	helix	NNS
cord-306948-wkisfz1m	229	42	(	(	-LRB-
cord-306948-wkisfz1m	229	43	Doan	Doan	NNP
cord-306948-wkisfz1m	229	44	and	and	CC
cord-306948-wkisfz1m	229	45	Dokland	Dokland	NNP
cord-306948-wkisfz1m	229	46	,	,	,
cord-306948-wkisfz1m	229	47	2003	2003	CD
cord-306948-wkisfz1m	229	48	;	;	:
cord-306948-wkisfz1m	229	49	Yoo	Yoo	NNP
cord-306948-wkisfz1m	229	50	et	et	NNP
cord-306948-wkisfz1m	229	51	al	al	NNP
cord-306948-wkisfz1m	229	52	.	.	NNP
cord-306948-wkisfz1m	229	53	,	,	,
cord-306948-wkisfz1m	229	54	2003	2003	CD
cord-306948-wkisfz1m	229	55	)	)	-RRB-
cord-306948-wkisfz1m	229	56	.	.	.
cord-306948-wkisfz1m	230	1	As	as	IN
cord-306948-wkisfz1m	230	2	the	the	DT
cord-306948-wkisfz1m	230	3	sole	sole	JJ
cord-306948-wkisfz1m	230	4	component	component	NN
cord-306948-wkisfz1m	230	5	of	of	IN
cord-306948-wkisfz1m	230	6	viral	viral	JJ
cord-306948-wkisfz1m	230	7	capsid	capsid	NN
cord-306948-wkisfz1m	230	8	,	,	,
cord-306948-wkisfz1m	230	9	N	N	NNP
cord-306948-wkisfz1m	230	10	interacts	interact	VBZ
cord-306948-wkisfz1m	230	11	with	with	IN
cord-306948-wkisfz1m	230	12	itself	-PRON-	PRP
cord-306948-wkisfz1m	230	13	via	via	IN
cord-306948-wkisfz1m	230	14	covalent	covalent	JJ
cord-306948-wkisfz1m	230	15	or	or	CC
cord-306948-wkisfz1m	230	16	noncovalent	noncovalent	NN
cord-306948-wkisfz1m	230	17	interactions	interaction	NNS
cord-306948-wkisfz1m	230	18	(	(	-LRB-
cord-306948-wkisfz1m	230	19	Doan	Doan	NNP
cord-306948-wkisfz1m	230	20	and	and	CC
cord-306948-wkisfz1m	230	21	Dokland	Dokland	NNP
cord-306948-wkisfz1m	230	22	,	,	,
cord-306948-wkisfz1m	230	23	2003	2003	CD
cord-306948-wkisfz1m	230	24	;	;	:
cord-306948-wkisfz1m	230	25	Wootton	Wootton	NNP
cord-306948-wkisfz1m	230	26	and	and	CC
cord-306948-wkisfz1m	230	27	Yoo	Yoo	NNP
cord-306948-wkisfz1m	230	28	,	,	,
cord-306948-wkisfz1m	230	29	2003	2003	CD
cord-306948-wkisfz1m	230	30	)	)	-RRB-
cord-306948-wkisfz1m	230	31	.	.	.
cord-306948-wkisfz1m	231	1	The	the	DT
cord-306948-wkisfz1m	231	2	cysteine	cysteine	NN
cord-306948-wkisfz1m	231	3	at	at	IN
cord-306948-wkisfz1m	231	4	position	position	NN
cord-306948-wkisfz1m	231	5	23	23	CD
cord-306948-wkisfz1m	231	6	is	be	VBZ
cord-306948-wkisfz1m	231	7	responsible	responsible	JJ
cord-306948-wkisfz1m	231	8	for	for	IN
cord-306948-wkisfz1m	231	9	the	the	DT
cord-306948-wkisfz1m	231	10	formation	formation	NN
cord-306948-wkisfz1m	231	11	of	of	IN
cord-306948-wkisfz1m	231	12	an	an	DT
cord-306948-wkisfz1m	231	13	intermolecular	intermolecular	JJ
cord-306948-wkisfz1m	231	14	disulfide	disulfide	NN
cord-306948-wkisfz1m	231	15	bond	bond	NN
cord-306948-wkisfz1m	231	16	,	,	,
cord-306948-wkisfz1m	231	17	and	and	CC
cord-306948-wkisfz1m	231	18	aa	aa	NNP
cord-306948-wkisfz1m	231	19	30	30	CD
cord-306948-wkisfz1m	231	20	-	-	SYM
cord-306948-wkisfz1m	231	21	37	37	CD
cord-306948-wkisfz1m	231	22	are	be	VBP
cord-306948-wkisfz1m	231	23	essential	essential	JJ
cord-306948-wkisfz1m	231	24	for	for	IN
cord-306948-wkisfz1m	231	25	mediating	mediate	VBG
cord-306948-wkisfz1m	231	26	noncovalent	noncovalent	NNP
cord-306948-wkisfz1m	231	27	homodimers	homodimer	NNS
cord-306948-wkisfz1m	231	28	.	.	.
cord-306948-wkisfz1m	232	1	A	a	DT
cord-306948-wkisfz1m	232	2	crystallographic	crystallographic	JJ
cord-306948-wkisfz1m	232	3	study	study	NN
cord-306948-wkisfz1m	232	4	on	on	IN
cord-306948-wkisfz1m	232	5	N	n	CD
cord-306948-wkisfz1m	232	6	shows	show	VBZ
cord-306948-wkisfz1m	232	7	the	the	DT
cord-306948-wkisfz1m	232	8	imprtance	imprtance	NN
cord-306948-wkisfz1m	232	9	of	of	IN
cord-306948-wkisfz1m	232	10	the	the	DT
cord-306948-wkisfz1m	232	11	C	C	NNP
cord-306948-wkisfz1m	232	12	-	-	HYPH
cord-306948-wkisfz1m	232	13	terminal	terminal	NN
cord-306948-wkisfz1m	232	14	dimerization	dimerization	NN
cord-306948-wkisfz1m	232	15	domain	domain	NN
cord-306948-wkisfz1m	232	16	for	for	IN
cord-306948-wkisfz1m	232	17	N	N	NNP
cord-306948-wkisfz1m	232	18	(	(	-LRB-
cord-306948-wkisfz1m	232	19	Doan	Doan	NNP
cord-306948-wkisfz1m	232	20	and	and	CC
cord-306948-wkisfz1m	232	21	Dokland	Dokland	NNP
cord-306948-wkisfz1m	232	22	,	,	,
cord-306948-wkisfz1m	232	23	2003	2003	CD
cord-306948-wkisfz1m	232	24	;	;	:
cord-306948-wkisfz1m	233	1	Spilman	Spilman	NNP
cord-306948-wkisfz1m	233	2	et	et	NNP
cord-306948-wkisfz1m	233	3	al	al	NNP
cord-306948-wkisfz1m	233	4	.	.	NNP
cord-306948-wkisfz1m	233	5	,	,	,
cord-306948-wkisfz1m	233	6	2009	2009	CD
cord-306948-wkisfz1m	233	7	)	)	-RRB-
cord-306948-wkisfz1m	233	8	.	.	.
cord-306948-wkisfz1m	234	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	234	2	N	N	NNP
cord-306948-wkisfz1m	234	3	is	be	VBZ
cord-306948-wkisfz1m	234	4	a	a	DT
cord-306948-wkisfz1m	234	5	serine	serine	NN
cord-306948-wkisfz1m	234	6	phosphoprotein	phosphoprotein	NN
cord-306948-wkisfz1m	234	7	which	which	WDT
cord-306948-wkisfz1m	234	8	is	be	VBZ
cord-306948-wkisfz1m	234	9	a	a	DT
cord-306948-wkisfz1m	234	10	common	common	JJ
cord-306948-wkisfz1m	234	11	property	property	NN
cord-306948-wkisfz1m	234	12	for	for	IN
cord-306948-wkisfz1m	234	13	N	n	CD
cord-306948-wkisfz1m	234	14	of	of	IN
cord-306948-wkisfz1m	234	15	EAV	EAV	NNP
cord-306948-wkisfz1m	234	16	and	and	CC
cord-306948-wkisfz1m	234	17	coronaviruses	coronaviruses	NNP
cord-306948-wkisfz1m	234	18	(	(	-LRB-
cord-306948-wkisfz1m	234	19	Music	Music	NNP
cord-306948-wkisfz1m	234	20	and	and	CC
cord-306948-wkisfz1m	234	21	Gagnon	Gagnon	NNP
cord-306948-wkisfz1m	234	22	,	,	,
cord-306948-wkisfz1m	234	23	2010	2010	CD
cord-306948-wkisfz1m	234	24	;	;	:
cord-306948-wkisfz1m	234	25	Wootton	Wootton	NNP
cord-306948-wkisfz1m	234	26	et	et	NNP
cord-306948-wkisfz1m	234	27	al	al	NNP
cord-306948-wkisfz1m	234	28	.	.	NNP
cord-306948-wkisfz1m	234	29	,	,	,
cord-306948-wkisfz1m	234	30	2002	2002	CD
cord-306948-wkisfz1m	234	31	)	)	-RRB-
cord-306948-wkisfz1m	234	32	.	.	.
cord-306948-wkisfz1m	235	1	One	one	CD
cord-306948-wkisfz1m	235	2	of	of	IN
cord-306948-wkisfz1m	235	3	the	the	DT
cord-306948-wkisfz1m	235	4	phosphorylation	phosphorylation	NN
cord-306948-wkisfz1m	235	5	sites	site	NNS
cord-306948-wkisfz1m	235	6	of	of	IN
cord-306948-wkisfz1m	235	7	N	N	NNP
cord-306948-wkisfz1m	235	8	is	be	VBZ
cord-306948-wkisfz1m	235	9	at	at	IN
cord-306948-wkisfz1m	235	10	position	position	NN
cord-306948-wkisfz1m	235	11	120	120	CD
cord-306948-wkisfz1m	235	12	,	,	,
cord-306948-wkisfz1m	235	13	but	but	CC
cord-306948-wkisfz1m	235	14	its	-PRON-	PRP$
cord-306948-wkisfz1m	235	15	biological	biological	JJ
cord-306948-wkisfz1m	235	16	significance	significance	NN
cord-306948-wkisfz1m	235	17	is	be	VBZ
cord-306948-wkisfz1m	235	18	still	still	RB
cord-306948-wkisfz1m	235	19	unknown	unknown	JJ
cord-306948-wkisfz1m	235	20	.	.	.
cord-306948-wkisfz1m	236	1	N	N	NNP
cord-306948-wkisfz1m	236	2	contains	contain	VBZ
cord-306948-wkisfz1m	236	3	NLS	nls	NN
cord-306948-wkisfz1m	236	4	in	in	IN
cord-306948-wkisfz1m	236	5	a	a	DT
cord-306948-wkisfz1m	236	6	stretch	stretch	NN
cord-306948-wkisfz1m	236	7	of	of	IN
cord-306948-wkisfz1m	236	8	basic	basic	JJ
cord-306948-wkisfz1m	236	9	amino	amino	NN
cord-306948-wkisfz1m	236	10	acids	acid	NNS
cord-306948-wkisfz1m	236	11	41-PGKKNKK-47	41-PGKKNKK-47	NNP
cord-306948-wkisfz1m	236	12	which	which	WDT
cord-306948-wkisfz1m	236	13	is	be	VBZ
cord-306948-wkisfz1m	236	14	overlapping	overlap	VBG
cord-306948-wkisfz1m	236	15	with	with	IN
cord-306948-wkisfz1m	236	16	the	the	DT
cord-306948-wkisfz1m	236	17	RNA	RNA	NNP
cord-306948-wkisfz1m	236	18	-	-	HYPH
cord-306948-wkisfz1m	236	19	binding	bind	VBG
cord-306948-wkisfz1m	236	20	domain	domain	NN
cord-306948-wkisfz1m	236	21	and	and	CC
cord-306948-wkisfz1m	236	22	particially	particially	NN
cord-306948-wkisfz1m	236	23	with	with	IN
cord-306948-wkisfz1m	236	24	a	a	DT
cord-306948-wkisfz1m	236	25	nucleolar	nucleolar	JJ
cord-306948-wkisfz1m	236	26	localization	localization	NN
cord-306948-wkisfz1m	236	27	signal	signal	NN
cord-306948-wkisfz1m	236	28	(	(	-LRB-
cord-306948-wkisfz1m	236	29	NoLS	NoLS	NNP
cord-306948-wkisfz1m	236	30	)	)	-RRB-
cord-306948-wkisfz1m	236	31	at	at	IN
cord-306948-wkisfz1m	236	32	aa	aa	NNP
cord-306948-wkisfz1m	236	33	41	41	CD
cord-306948-wkisfz1m	236	34	-	-	SYM
cord-306948-wkisfz1m	236	35	72	72	CD
cord-306948-wkisfz1m	237	1	(	(	-LRB-
cord-306948-wkisfz1m	237	2	Rowland	Rowland	NNP
cord-306948-wkisfz1m	237	3	et	et	NNP
cord-306948-wkisfz1m	237	4	al	al	NNP
cord-306948-wkisfz1m	237	5	.	.	NNP
cord-306948-wkisfz1m	237	6	,	,	,
cord-306948-wkisfz1m	237	7	1999	1999	CD
cord-306948-wkisfz1m	237	8	.	.	.
cord-306948-wkisfz1m	238	1	The	the	DT
cord-306948-wkisfz1m	238	2	nuclear	nuclear	JJ
cord-306948-wkisfz1m	238	3	export	export	NN
cord-306948-wkisfz1m	238	4	signal	signal	NN
cord-306948-wkisfz1m	238	5	(	(	-LRB-
cord-306948-wkisfz1m	238	6	NES	NES	NNP
cord-306948-wkisfz1m	238	7	)	)	-RRB-
cord-306948-wkisfz1m	238	8	is	be	VBZ
cord-306948-wkisfz1m	238	9	found	find	VBN
cord-306948-wkisfz1m	238	10	at	at	IN
cord-306948-wkisfz1m	238	11	positions	position	NNS
cord-306948-wkisfz1m	238	12	106	106	CD
cord-306948-wkisfz1m	238	13	-	-	SYM
cord-306948-wkisfz1m	238	14	117	117	CD
cord-306948-wkisfz1m	238	15	and	and	CC
cord-306948-wkisfz1m	238	16	is	be	VBZ
cord-306948-wkisfz1m	238	17	responsible	responsible	JJ
cord-306948-wkisfz1m	238	18	for	for	IN
cord-306948-wkisfz1m	238	19	the	the	DT
cord-306948-wkisfz1m	238	20	nucleolar	nucleolar	JJ
cord-306948-wkisfz1m	238	21	-	-	HYPH
cord-306948-wkisfz1m	238	22	cytoplasmic	cytoplasmic	JJ
cord-306948-wkisfz1m	238	23	shuttling	shuttling	NN
cord-306948-wkisfz1m	238	24	of	of	IN
cord-306948-wkisfz1m	238	25	N	n	CD
cord-306948-wkisfz1m	238	26	.	.	.
cord-306948-wkisfz1m	239	1	The	the	DT
cord-306948-wkisfz1m	239	2	functional	functional	JJ
cord-306948-wkisfz1m	239	3	structure	structure	NN
cord-306948-wkisfz1m	239	4	of	of	IN
cord-306948-wkisfz1m	239	5	N	N	NNP
cord-306948-wkisfz1m	239	6	is	be	VBZ
cord-306948-wkisfz1m	239	7	compact	compact	JJ
cord-306948-wkisfz1m	239	8	and	and	CC
cord-306948-wkisfz1m	239	9	thus	thus	RB
cord-306948-wkisfz1m	239	10	N	N	NNP
cord-306948-wkisfz1m	239	11	is	be	VBZ
cord-306948-wkisfz1m	239	12	sensitive	sensitive	JJ
cord-306948-wkisfz1m	239	13	to	to	IN
cord-306948-wkisfz1m	239	14	structural	structural	JJ
cord-306948-wkisfz1m	239	15	modification	modification	NN
cord-306948-wkisfz1m	239	16	.	.	.
cord-306948-wkisfz1m	240	1	The	the	DT
cord-306948-wkisfz1m	240	2	secondary	secondary	JJ
cord-306948-wkisfz1m	240	3	structure	structure	NN
cord-306948-wkisfz1m	240	4	in	in	IN
cord-306948-wkisfz1m	240	5	the	the	DT
cord-306948-wkisfz1m	240	6	C	c	NN
cord-306948-wkisfz1m	240	7	-	-	HYPH
cord-306948-wkisfz1m	240	8	terminal	terminal	NN
cord-306948-wkisfz1m	240	9	residues	residue	NNS
cord-306948-wkisfz1m	240	10	112	112	CD
cord-306948-wkisfz1m	240	11	-	-	SYM
cord-306948-wkisfz1m	240	12	123	123	CD
cord-306948-wkisfz1m	240	13	is	be	VBZ
cord-306948-wkisfz1m	240	14	an	an	DT
cord-306948-wkisfz1m	240	15	important	important	JJ
cord-306948-wkisfz1m	240	16	determinant	determinant	NN
cord-306948-wkisfz1m	240	17	for	for	IN
cord-306948-wkisfz1m	240	18	conformational	conformational	JJ
cord-306948-wkisfz1m	240	19	epitopes	epitope	NNS
cord-306948-wkisfz1m	240	20	,	,	,
cord-306948-wkisfz1m	240	21	and	and	CC
cord-306948-wkisfz1m	240	22	the	the	DT
cord-306948-wkisfz1m	240	23	mutations	mutation	NNS
cord-306948-wkisfz1m	240	24	in	in	IN
cord-306948-wkisfz1m	240	25	this	this	DT
cord-306948-wkisfz1m	240	26	region	region	NN
cord-306948-wkisfz1m	240	27	change	change	VB
cord-306948-wkisfz1m	240	28	the	the	DT
cord-306948-wkisfz1m	240	29	monoclonal	monoclonal	JJ
cord-306948-wkisfz1m	240	30	antibody	antibody	NN
cord-306948-wkisfz1m	240	31	(	(	-LRB-
cord-306948-wkisfz1m	240	32	MAb	MAb	NNS
cord-306948-wkisfz1m	240	33	)	)	-RRB-
cord-306948-wkisfz1m	240	34	reactivity	reactivity	NN
cord-306948-wkisfz1m	240	35	(	(	-LRB-
cord-306948-wkisfz1m	240	36	Wootton	Wootton	NNP
cord-306948-wkisfz1m	240	37	et	et	NNP
cord-306948-wkisfz1m	240	38	al	al	NNP
cord-306948-wkisfz1m	240	39	.	.	NNP
cord-306948-wkisfz1m	240	40	,	,	,
cord-306948-wkisfz1m	240	41	2001	2001	CD
cord-306948-wkisfz1m	240	42	)	)	-RRB-
cord-306948-wkisfz1m	240	43	.	.	.
cord-306948-wkisfz1m	241	1	Insertion	insertion	NN
cord-306948-wkisfz1m	241	2	of	of	IN
cord-306948-wkisfz1m	241	3	a	a	DT
cord-306948-wkisfz1m	241	4	foreign	foreign	JJ
cord-306948-wkisfz1m	241	5	sequence	sequence	NN
cord-306948-wkisfz1m	241	6	into	into	IN
cord-306948-wkisfz1m	241	7	the	the	DT
cord-306948-wkisfz1m	241	8	N	n	CD
cord-306948-wkisfz1m	241	9	gene	gene	NN
cord-306948-wkisfz1m	241	10	was	be	VBD
cord-306948-wkisfz1m	241	11	attemped	attempe	VBN
cord-306948-wkisfz1m	241	12	and	and	CC
cord-306948-wkisfz1m	241	13	the	the	DT
cord-306948-wkisfz1m	241	14	influenza	influenza	NN
cord-306948-wkisfz1m	241	15	virus	virus	NN
cord-306948-wkisfz1m	241	16	HA	HA	NNP
cord-306948-wkisfz1m	241	17	epitope	epitope	NN
cord-306948-wkisfz1m	241	18	was	be	VBD
cord-306948-wkisfz1m	241	19	added	add	VBN
cord-306948-wkisfz1m	241	20	at	at	IN
cord-306948-wkisfz1m	241	21	the	the	DT
cord-306948-wkisfz1m	241	22	N	n	CD
cord-306948-wkisfz1m	241	23	-	-	HYPH
cord-306948-wkisfz1m	241	24	terminus	terminus	NN
cord-306948-wkisfz1m	241	25	or	or	CC
cord-306948-wkisfz1m	241	26	Cterminus	Cterminus	NNP
cord-306948-wkisfz1m	241	27	.	.	.
cord-306948-wkisfz1m	242	1	Despite	despite	IN
cord-306948-wkisfz1m	242	2	the	the	DT
cord-306948-wkisfz1m	242	3	initial	initial	JJ
cord-306948-wkisfz1m	242	4	rescue	rescue	NN
cord-306948-wkisfz1m	242	5	of	of	IN
cord-306948-wkisfz1m	242	6	the	the	DT
cord-306948-wkisfz1m	242	7	infectious	infectious	JJ
cord-306948-wkisfz1m	242	8	virus	virus	NN
cord-306948-wkisfz1m	242	9	,	,	,
cord-306948-wkisfz1m	242	10	the	the	DT
cord-306948-wkisfz1m	242	11	HA	HA	NNP
cord-306948-wkisfz1m	242	12	expression	expression	NN
cord-306948-wkisfz1m	242	13	was	be	VBD
cord-306948-wkisfz1m	242	14	unsuccessful	unsuccessful	JJ
cord-306948-wkisfz1m	243	1	(	(	-LRB-
cord-306948-wkisfz1m	243	2	Bramel	Bramel	NNP
cord-306948-wkisfz1m	243	3	-	-	HYPH
cord-306948-wkisfz1m	243	4	Verheije	Verheije	NNP
cord-306948-wkisfz1m	243	5	et	et	FW
cord-306948-wkisfz1m	243	6	al	al	NNP
cord-306948-wkisfz1m	243	7	.	.	NNP
cord-306948-wkisfz1m	243	8	,	,	,
cord-306948-wkisfz1m	243	9	2000	2000	CD
cord-306948-wkisfz1m	243	10	)	)	-RRB-
cord-306948-wkisfz1m	243	11	.	.	.
cord-306948-wkisfz1m	244	1	The	the	DT
cord-306948-wkisfz1m	244	2	GFP	GFP	NNP
cord-306948-wkisfz1m	244	3	tag	tag	NN
cord-306948-wkisfz1m	244	4	was	be	VBD
cord-306948-wkisfz1m	244	5	inserted	insert	VBN
cord-306948-wkisfz1m	244	6	between	between	IN
cord-306948-wkisfz1m	244	7	ORF6	ORF6	NNP
cord-306948-wkisfz1m	244	8	and	and	CC
cord-306948-wkisfz1m	244	9	ORF7	ORF7	NNP
cord-306948-wkisfz1m	244	10	to	to	TO
cord-306948-wkisfz1m	244	11	moniter	moniter	VB
cord-306948-wkisfz1m	244	12	the	the	DT
cord-306948-wkisfz1m	244	13	ORF7	ORF7	NNP
cord-306948-wkisfz1m	244	14	mRNA	mRNA	NNP
cord-306948-wkisfz1m	244	15	synthesis	synthesis	NN
cord-306948-wkisfz1m	244	16	,	,	,
cord-306948-wkisfz1m	244	17	but	but	CC
cord-306948-wkisfz1m	244	18	no	no	DT
cord-306948-wkisfz1m	244	19	mRNA	mrna	NN
cord-306948-wkisfz1m	244	20	was	be	VBD
cord-306948-wkisfz1m	244	21	made	make	VBN
cord-306948-wkisfz1m	244	22	,	,	,
cord-306948-wkisfz1m	244	23	indicating	indicate	VBG
cord-306948-wkisfz1m	244	24	the	the	DT
cord-306948-wkisfz1m	244	25	5	5	CD
cord-306948-wkisfz1m	244	26	0	0	CD
cord-306948-wkisfz1m	244	27	end	end	NN
cord-306948-wkisfz1m	244	28	of	of	IN
cord-306948-wkisfz1m	244	29	the	the	DT
cord-306948-wkisfz1m	244	30	ORF7	ORF7	NNP
cord-306948-wkisfz1m	244	31	gene	gene	NN
cord-306948-wkisfz1m	244	32	is	be	VBZ
cord-306948-wkisfz1m	244	33	essential	essential	JJ
cord-306948-wkisfz1m	244	34	for	for	IN
cord-306948-wkisfz1m	244	35	mRNA	mRNA	NNP
cord-306948-wkisfz1m	244	36	synthesis	synthesis	NN
cord-306948-wkisfz1m	244	37	.	.	.
cord-306948-wkisfz1m	245	1	The	the	DT
cord-306948-wkisfz1m	245	2	N	N	NNP
cord-306948-wkisfz1m	245	3	protein	protein	NN
cord-306948-wkisfz1m	245	4	is	be	VBZ
cord-306948-wkisfz1m	245	5	inter	inter	JJ
cord-306948-wkisfz1m	245	6	-	-	JJ
cord-306948-wkisfz1m	245	7	genotypically	genotypically	RB
cord-306948-wkisfz1m	245	8	conserved	conserve	VBN
cord-306948-wkisfz1m	245	9	but	but	CC
cord-306948-wkisfz1m	245	10	shares	share	NNS
cord-306948-wkisfz1m	245	11	only	only	RB
cord-306948-wkisfz1m	245	12	60	60	CD
cord-306948-wkisfz1m	245	13	%	%	NN
cord-306948-wkisfz1m	245	14	of	of	IN
cord-306948-wkisfz1m	245	15	its	-PRON-	PRP$
cord-306948-wkisfz1m	245	16	identity	identity	NN
cord-306948-wkisfz1m	245	17	between	between	IN
cord-306948-wkisfz1m	245	18	LV	LV	NNP
cord-306948-wkisfz1m	245	19	and	and	CC
cord-306948-wkisfz1m	245	20	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	246	1	(	(	-LRB-
cord-306948-wkisfz1m	246	2	Dea	Dea	NNP
cord-306948-wkisfz1m	246	3	et	et	FW
cord-306948-wkisfz1m	246	4	al	al	NNP
cord-306948-wkisfz1m	246	5	.	.	NNP
cord-306948-wkisfz1m	246	6	,	,	,
cord-306948-wkisfz1m	246	7	2000	2000	CD
cord-306948-wkisfz1m	246	8	)	)	-RRB-
cord-306948-wkisfz1m	246	9	.	.	.
cord-306948-wkisfz1m	247	1	The	the	DT
cord-306948-wkisfz1m	247	2	C	c	NN
cord-306948-wkisfz1m	247	3	-	-	HYPH
cord-306948-wkisfz1m	247	4	terminus	terminus	NN
cord-306948-wkisfz1m	247	5	of	of	IN
cord-306948-wkisfz1m	247	6	N	N	NNP
cord-306948-wkisfz1m	247	7	is	be	VBZ
cord-306948-wkisfz1m	247	8	heterogenous	heterogenous	JJ
cord-306948-wkisfz1m	247	9	,	,	,
cord-306948-wkisfz1m	247	10	and	and	CC
cord-306948-wkisfz1m	247	11	truncation	truncation	NN
cord-306948-wkisfz1m	247	12	of	of	IN
cord-306948-wkisfz1m	247	13	up	up	IN
cord-306948-wkisfz1m	247	14	to	to	TO
cord-306948-wkisfz1m	247	15	6	6	CD
cord-306948-wkisfz1m	247	16	aa	aa	NNP
cord-306948-wkisfz1m	247	17	is	be	VBZ
cord-306948-wkisfz1m	247	18	tolerable	tolerable	JJ
cord-306948-wkisfz1m	248	1	(	(	-LRB-
cord-306948-wkisfz1m	248	2	Verheije	Verheije	NNP
cord-306948-wkisfz1m	248	3	et	et	FW
cord-306948-wkisfz1m	248	4	al	al	NNP
cord-306948-wkisfz1m	248	5	.	.	NNP
cord-306948-wkisfz1m	248	6	,	,	,
cord-306948-wkisfz1m	248	7	2001	2001	CD
cord-306948-wkisfz1m	248	8	)	)	-RRB-
cord-306948-wkisfz1m	248	9	.	.	.
cord-306948-wkisfz1m	249	1	In	in	IN
cord-306948-wkisfz1m	249	2	another	another	DT
cord-306948-wkisfz1m	249	3	study	study	NN
cord-306948-wkisfz1m	249	4	,	,	,
cord-306948-wkisfz1m	249	5	deletions	deletion	NNS
cord-306948-wkisfz1m	249	6	were	be	VBD
cord-306948-wkisfz1m	249	7	made	make	VBN
cord-306948-wkisfz1m	249	8	at	at	IN
cord-306948-wkisfz1m	249	9	the	the	DT
cord-306948-wkisfz1m	249	10	inter	inter	JJ
cord-306948-wkisfz1m	249	11	-	-	JJ
cord-306948-wkisfz1m	249	12	genotypic	genotypic	JJ
cord-306948-wkisfz1m	249	13	variable	variable	JJ
cord-306948-wkisfz1m	249	14	region	region	NN
cord-306948-wkisfz1m	249	15	or	or	CC
cord-306948-wkisfz1m	249	16	conserved	conserved	JJ
cord-306948-wkisfz1m	249	17	region	region	NN
cord-306948-wkisfz1m	249	18	of	of	IN
cord-306948-wkisfz1m	249	19	N	N	NNP
cord-306948-wkisfz1m	249	20	,	,	,
cord-306948-wkisfz1m	249	21	and	and	CC
cord-306948-wkisfz1m	249	22	4	4	CD
cord-306948-wkisfz1m	249	23	regions	region	NNS
cord-306948-wkisfz1m	249	24	at	at	IN
cord-306948-wkisfz1m	249	25	5	5	CD
cord-306948-wkisfz1m	249	26	-	-	SYM
cord-306948-wkisfz1m	249	27	13	13	CD
cord-306948-wkisfz1m	249	28	,	,	,
cord-306948-wkisfz1m	249	29	39	39	CD
cord-306948-wkisfz1m	249	30	-	-	SYM
cord-306948-wkisfz1m	249	31	42	42	CD
cord-306948-wkisfz1m	249	32	,	,	,
cord-306948-wkisfz1m	249	33	48	48	CD
cord-306948-wkisfz1m	249	34	-	-	SYM
cord-306948-wkisfz1m	249	35	52	52	CD
cord-306948-wkisfz1m	249	36	,	,	,
cord-306948-wkisfz1m	249	37	and	and	CC
cord-306948-wkisfz1m	249	38	120	120	CD
cord-306948-wkisfz1m	249	39	-	-	SYM
cord-306948-wkisfz1m	249	40	123	123	CD
cord-306948-wkisfz1m	249	41	,	,	,
cord-306948-wkisfz1m	249	42	were	be	VBD
cord-306948-wkisfz1m	249	43	found	find	VBN
cord-306948-wkisfz1m	249	44	to	to	TO
cord-306948-wkisfz1m	249	45	be	be	VB
cord-306948-wkisfz1m	249	46	dispensible	dispensible	JJ
cord-306948-wkisfz1m	249	47	for	for	IN
cord-306948-wkisfz1m	249	48	viability	viability	NN
cord-306948-wkisfz1m	249	49	(	(	-LRB-
cord-306948-wkisfz1m	249	50	Fig	fig	NN
cord-306948-wkisfz1m	249	51	.	.	.
cord-306948-wkisfz1m	249	52	3B	3b	LS
cord-306948-wkisfz1m	249	53	)	)	-RRB-
cord-306948-wkisfz1m	250	1	(	(	-LRB-
cord-306948-wkisfz1m	250	2	Tan	Tan	NNP
cord-306948-wkisfz1m	250	3	et	et	FW
cord-306948-wkisfz1m	250	4	al	al	NNP
cord-306948-wkisfz1m	250	5	.	.	NNP
cord-306948-wkisfz1m	250	6	,	,	,
cord-306948-wkisfz1m	250	7	2011	2011	CD
cord-306948-wkisfz1m	250	8	)	)	-RRB-
cord-306948-wkisfz1m	250	9	.	.	.
cord-306948-wkisfz1m	251	1	No	no	DT
cord-306948-wkisfz1m	251	2	foreign	foreign	JJ
cord-306948-wkisfz1m	251	3	gene	gene	NN
cord-306948-wkisfz1m	251	4	can	can	MD
cord-306948-wkisfz1m	251	5	be	be	VB
cord-306948-wkisfz1m	251	6	incorporated	incorporate	VBN
cord-306948-wkisfz1m	251	7	in	in	IN
cord-306948-wkisfz1m	251	8	these	these	DT
cord-306948-wkisfz1m	251	9	rgions	rgion	NNS
cord-306948-wkisfz1m	251	10	.	.	.
cord-306948-wkisfz1m	252	1	The	the	DT
cord-306948-wkisfz1m	252	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	252	3	genome	genome	NN
cord-306948-wkisfz1m	252	4	is	be	VBZ
cord-306948-wkisfz1m	252	5	flanked	flank	VBN
cord-306948-wkisfz1m	252	6	by	by	IN
cord-306948-wkisfz1m	252	7	5	5	CD
cord-306948-wkisfz1m	252	8	0	0	CD
cord-306948-wkisfz1m	252	9	-and	-and	SYM
cord-306948-wkisfz1m	252	10	3	3	CD
cord-306948-wkisfz1m	252	11	0	0	CD
cord-306948-wkisfz1m	252	12	-UTR	-utr	NN
cord-306948-wkisfz1m	252	13	,	,	,
cord-306948-wkisfz1m	252	14	and	and	CC
cord-306948-wkisfz1m	252	15	the	the	DT
cord-306948-wkisfz1m	252	16	UTR	UTR	NNP
cord-306948-wkisfz1m	252	17	sequences	sequence	NNS
cord-306948-wkisfz1m	252	18	play	play	VBP
cord-306948-wkisfz1m	252	19	a	a	DT
cord-306948-wkisfz1m	252	20	vital	vital	JJ
cord-306948-wkisfz1m	252	21	role	role	NN
cord-306948-wkisfz1m	252	22	for	for	IN
cord-306948-wkisfz1m	252	23	genomic	genomic	JJ
cord-306948-wkisfz1m	252	24	replication	replication	NN
cord-306948-wkisfz1m	252	25	,	,	,
cord-306948-wkisfz1m	252	26	mRNA	mrna	NN
cord-306948-wkisfz1m	252	27	transcription	transcription	NN
cord-306948-wkisfz1m	252	28	,	,	,
cord-306948-wkisfz1m	252	29	and	and	CC
cord-306948-wkisfz1m	252	30	protein	protein	NN
cord-306948-wkisfz1m	252	31	translation	translation	NN
cord-306948-wkisfz1m	253	1	(	(	-LRB-
cord-306948-wkisfz1m	253	2	Pasternak	Pasternak	NNP
cord-306948-wkisfz1m	253	3	et	et	NNP
cord-306948-wkisfz1m	253	4	al	al	NNP
cord-306948-wkisfz1m	253	5	.	.	NNP
cord-306948-wkisfz1m	253	6	,	,	,
cord-306948-wkisfz1m	253	7	2006	2006	CD
cord-306948-wkisfz1m	254	1	;	;	:
cord-306948-wkisfz1m	254	2	Snijder	Snijder	NNP
cord-306948-wkisfz1m	254	3	et	et	NNP
cord-306948-wkisfz1m	254	4	al	al	NNP
cord-306948-wkisfz1m	254	5	.	.	NNP
cord-306948-wkisfz1m	254	6	,	,	,
cord-306948-wkisfz1m	254	7	2013	2013	CD
cord-306948-wkisfz1m	254	8	)	)	-RRB-
cord-306948-wkisfz1m	254	9	.	.	.
cord-306948-wkisfz1m	255	1	The	the	DT
cord-306948-wkisfz1m	255	2	non	non	JJ
cord-306948-wkisfz1m	255	3	-	-	JJ
cord-306948-wkisfz1m	255	4	coding	coding	JJ
cord-306948-wkisfz1m	255	5	regions	region	NNS
cord-306948-wkisfz1m	255	6	of	of	IN
cord-306948-wkisfz1m	255	7	the	the	DT
cord-306948-wkisfz1m	255	8	genome	genome	NN
cord-306948-wkisfz1m	255	9	have	have	VBP
cord-306948-wkisfz1m	255	10	been	be	VBN
cord-306948-wkisfz1m	255	11	investigated	investigate	VBN
cord-306948-wkisfz1m	255	12	.	.	.
cord-306948-wkisfz1m	256	1	By	by	IN
cord-306948-wkisfz1m	256	2	serial	serial	JJ
cord-306948-wkisfz1m	256	3	deletions	deletion	NNS
cord-306948-wkisfz1m	256	4	,	,	,
cord-306948-wkisfz1m	256	5	the	the	DT
cord-306948-wkisfz1m	256	6	first	first	JJ
cord-306948-wkisfz1m	256	7	3	3	CD
cord-306948-wkisfz1m	256	8	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	256	9	in	in	IN
cord-306948-wkisfz1m	256	10	5	5	CD
cord-306948-wkisfz1m	256	11	0	0	CD
cord-306948-wkisfz1m	256	12	-UTR	-utr	NN
cord-306948-wkisfz1m	256	13	appears	appear	VBZ
cord-306948-wkisfz1m	256	14	to	to	TO
cord-306948-wkisfz1m	256	15	be	be	VB
cord-306948-wkisfz1m	256	16	dispensible	dispensible	JJ
cord-306948-wkisfz1m	256	17	for	for	IN
cord-306948-wkisfz1m	256	18	viability	viability	NN
cord-306948-wkisfz1m	256	19	in	in	IN
cord-306948-wkisfz1m	256	20	type	type	NN
cord-306948-wkisfz1m	256	21	II	II	NNP
cord-306948-wkisfz1m	256	22	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	256	23	first	first	RB
cord-306948-wkisfz1m	256	24	11	11	CD
cord-306948-wkisfz1m	256	25	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	256	26	are	be	VBP
cord-306948-wkisfz1m	256	27	unique	unique	JJ
cord-306948-wkisfz1m	256	28	for	for	IN
cord-306948-wkisfz1m	256	29	each	each	DT
cord-306948-wkisfz1m	256	30	genotype	genotype	NN
cord-306948-wkisfz1m	256	31	,	,	,
cord-306948-wkisfz1m	256	32	and	and	CC
cord-306948-wkisfz1m	256	33	a	a	DT
cord-306948-wkisfz1m	256	34	stretch	stretch	NN
cord-306948-wkisfz1m	256	35	of	of	IN
cord-306948-wkisfz1m	256	36	38	38	CD
cord-306948-wkisfz1m	256	37	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	256	38	is	be	VBZ
cord-306948-wkisfz1m	256	39	present	present	JJ
cord-306948-wkisfz1m	256	40	in	in	IN
cord-306948-wkisfz1m	256	41	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	256	42	but	but	CC
cord-306948-wkisfz1m	256	43	is	be	VBZ
cord-306948-wkisfz1m	256	44	absent	absent	JJ
cord-306948-wkisfz1m	256	45	in	in	IN
cord-306948-wkisfz1m	256	46	LV	LV	NNP
cord-306948-wkisfz1m	256	47	(	(	-LRB-
cord-306948-wkisfz1m	256	48	Allende	Allende	NNP
cord-306948-wkisfz1m	256	49	et	et	NNP
cord-306948-wkisfz1m	256	50	al	al	NNP
cord-306948-wkisfz1m	256	51	.	.	NNP
cord-306948-wkisfz1m	256	52	,	,	,
cord-306948-wkisfz1m	256	53	1999	1999	CD
cord-306948-wkisfz1m	256	54	;	;	:
cord-306948-wkisfz1m	256	55	Verheije	Verheije	NNP
cord-306948-wkisfz1m	256	56	et	et	FW
cord-306948-wkisfz1m	256	57	al	al	NNP
cord-306948-wkisfz1m	256	58	.	.	NNP
cord-306948-wkisfz1m	256	59	,	,	,
cord-306948-wkisfz1m	256	60	2001	2001	CD
cord-306948-wkisfz1m	256	61	)	)	-RRB-
cord-306948-wkisfz1m	256	62	.	.	.
cord-306948-wkisfz1m	257	1	A	a	DT
cord-306948-wkisfz1m	257	2	deletion	deletion	NN
cord-306948-wkisfz1m	257	3	study	study	NN
cord-306948-wkisfz1m	257	4	shows	show	VBZ
cord-306948-wkisfz1m	257	5	that	that	IN
cord-306948-wkisfz1m	257	6	7	7	CD
cord-306948-wkisfz1m	257	7	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	257	8	at	at	IN
cord-306948-wkisfz1m	257	9	the	the	DT
cord-306948-wkisfz1m	257	10	5	5	CD
cord-306948-wkisfz1m	257	11	0	0	CD
cord-306948-wkisfz1m	257	12	end	end	NN
cord-306948-wkisfz1m	257	13	of	of	IN
cord-306948-wkisfz1m	257	14	the	the	DT
cord-306948-wkisfz1m	257	15	3	3	CD
cord-306948-wkisfz1m	257	16	0	0	CD
cord-306948-wkisfz1m	257	17	-UTR	-utr	NN
cord-306948-wkisfz1m	257	18	is	be	VBZ
cord-306948-wkisfz1m	257	19	tolerable	tolerable	JJ
cord-306948-wkisfz1m	257	20	for	for	IN
cord-306948-wkisfz1m	257	21	genotype	genotype	NN
cord-306948-wkisfz1m	257	22	I	-PRON-	PRP
cord-306948-wkisfz1m	257	23	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	258	1	(	(	-LRB-
cord-306948-wkisfz1m	258	2	Verheije	Verheije	NNP
cord-306948-wkisfz1m	258	3	et	et	FW
cord-306948-wkisfz1m	258	4	al	al	NNP
cord-306948-wkisfz1m	258	5	.	.	NNP
cord-306948-wkisfz1m	258	6	,	,	,
cord-306948-wkisfz1m	258	7	2001	2001	CD
cord-306948-wkisfz1m	258	8	)	)	-RRB-
cord-306948-wkisfz1m	258	9	.	.	.
cord-306948-wkisfz1m	259	1	The	the	DT
cord-306948-wkisfz1m	259	2	3	3	CD
cord-306948-wkisfz1m	259	3	0	0	CD
cord-306948-wkisfz1m	259	4	-UTR	-utr	NN
cord-306948-wkisfz1m	259	5	of	of	IN
cord-306948-wkisfz1m	259	6	genotype	genotype	NNP
cord-306948-wkisfz1m	259	7	II	II	NNP
cord-306948-wkisfz1m	259	8	has	have	VBZ
cord-306948-wkisfz1m	259	9	also	also	RB
cord-306948-wkisfz1m	259	10	been	be	VBN
cord-306948-wkisfz1m	259	11	studied	study	VBN
cord-306948-wkisfz1m	259	12	,	,	,
cord-306948-wkisfz1m	259	13	and	and	CC
cord-306948-wkisfz1m	260	1	at	at	RB
cord-306948-wkisfz1m	260	2	least	least	RBS
cord-306948-wkisfz1m	260	3	40	40	CD
cord-306948-wkisfz1m	260	4	nucleotides	nucleotide	NNS
cord-306948-wkisfz1m	260	5	immediately	immediately	RB
cord-306948-wkisfz1m	260	6	following	follow	VBG
cord-306948-wkisfz1m	260	7	ORF7	ORF7	NNP
cord-306948-wkisfz1m	260	8	is	be	VBZ
cord-306948-wkisfz1m	260	9	dispensable	dispensable	JJ
cord-306948-wkisfz1m	260	10	for	for	IN
cord-306948-wkisfz1m	260	11	virus	virus	NN
cord-306948-wkisfz1m	260	12	viability	viability	NN
cord-306948-wkisfz1m	260	13	.	.	.
cord-306948-wkisfz1m	261	1	The	the	DT
cord-306948-wkisfz1m	261	2	genetic	genetic	JJ
cord-306948-wkisfz1m	261	3	information	information	NN
cord-306948-wkisfz1m	261	4	on	on	IN
cord-306948-wkisfz1m	261	5	the	the	DT
cord-306948-wkisfz1m	261	6	structural	structural	JJ
cord-306948-wkisfz1m	261	7	region	region	NN
cord-306948-wkisfz1m	261	8	of	of	IN
cord-306948-wkisfz1m	261	9	arteriviruses	arteriviruses	NNP
cord-306948-wkisfz1m	261	10	is	be	VBZ
cord-306948-wkisfz1m	261	11	organized	organize	VBN
cord-306948-wkisfz1m	261	12	in	in	IN
cord-306948-wkisfz1m	261	13	an	an	DT
cord-306948-wkisfz1m	261	14	extremely	extremely	RB
cord-306948-wkisfz1m	261	15	efficient	efficient	JJ
cord-306948-wkisfz1m	261	16	manner	manner	NN
cord-306948-wkisfz1m	261	17	.	.	.
cord-306948-wkisfz1m	262	1	The	the	DT
cord-306948-wkisfz1m	262	2	genes	gene	NNS
cord-306948-wkisfz1m	262	3	for	for	IN
cord-306948-wkisfz1m	262	4	GP2	GP2	NNP
cord-306948-wkisfz1m	262	5	,	,	,
cord-306948-wkisfz1m	262	6	GP3	GP3	NNP
cord-306948-wkisfz1m	262	7	,	,	,
cord-306948-wkisfz1m	262	8	and	and	CC
cord-306948-wkisfz1m	262	9	GP4	GP4	NNP
cord-306948-wkisfz1m	262	10	overlap	overlap	VBP
cord-306948-wkisfz1m	262	11	each	each	DT
cord-306948-wkisfz1m	262	12	other	other	JJ
cord-306948-wkisfz1m	262	13	,	,	,
cord-306948-wkisfz1m	262	14	and	and	CC
cord-306948-wkisfz1m	262	15	similarly	similarly	RB
cord-306948-wkisfz1m	262	16	the	the	DT
cord-306948-wkisfz1m	262	17	genes	gene	NNS
cord-306948-wkisfz1m	262	18	for	for	IN
cord-306948-wkisfz1m	262	19	GP5	GP5	NNP
cord-306948-wkisfz1m	262	20	,	,	,
cord-306948-wkisfz1m	262	21	M	M	NNP
cord-306948-wkisfz1m	262	22	,	,	,
cord-306948-wkisfz1m	262	23	and	and	CC
cord-306948-wkisfz1m	262	24	N	n	CD
cord-306948-wkisfz1m	262	25	overlap	overlap	VBP
cord-306948-wkisfz1m	262	26	each	each	DT
cord-306948-wkisfz1m	262	27	other	other	JJ
cord-306948-wkisfz1m	262	28	for	for	IN
cord-306948-wkisfz1m	262	29	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	262	30	.	.	.
cord-306948-wkisfz1m	263	1	This	this	DT
cord-306948-wkisfz1m	263	2	structural	structural	JJ
cord-306948-wkisfz1m	263	3	complexicity	complexicity	NN
cord-306948-wkisfz1m	263	4	hampers	hamper	VBZ
cord-306948-wkisfz1m	263	5	the	the	DT
cord-306948-wkisfz1m	263	6	genetic	genetic	JJ
cord-306948-wkisfz1m	263	7	manipulation	manipulation	NN
cord-306948-wkisfz1m	263	8	of	of	IN
cord-306948-wkisfz1m	263	9	infectious	infectious	JJ
cord-306948-wkisfz1m	263	10	clones	clone	NNS
cord-306948-wkisfz1m	263	11	.	.	.
cord-306948-wkisfz1m	264	1	The	the	DT
cord-306948-wkisfz1m	264	2	importance	importance	NN
cord-306948-wkisfz1m	264	3	of	of	IN
cord-306948-wkisfz1m	264	4	the	the	DT
cord-306948-wkisfz1m	264	5	overlapping	overlap	VBG
cord-306948-wkisfz1m	264	6	gene	gene	NN
cord-306948-wkisfz1m	264	7	arrangement	arrangement	NN
cord-306948-wkisfz1m	264	8	for	for	IN
cord-306948-wkisfz1m	264	9	the	the	DT
cord-306948-wkisfz1m	264	10	life	life	NN
cord-306948-wkisfz1m	264	11	-	-	HYPH
cord-306948-wkisfz1m	264	12	cycle	cycle	NN
cord-306948-wkisfz1m	264	13	of	of	IN
cord-306948-wkisfz1m	264	14	virus	virus	NN
cord-306948-wkisfz1m	264	15	has	have	VBZ
cord-306948-wkisfz1m	264	16	been	be	VBN
cord-306948-wkisfz1m	264	17	studied	study	VBN
cord-306948-wkisfz1m	264	18	(	(	-LRB-
cord-306948-wkisfz1m	265	1	Verheije	Verheije	NNP
cord-306948-wkisfz1m	265	2	et	et	FW
cord-306948-wkisfz1m	265	3	al	al	NNP
cord-306948-wkisfz1m	265	4	.	.	.
cord-306948-wkisfz1m	266	1	,	,	,
cord-306948-wkisfz1m	266	2	2002	2002	CD
cord-306948-wkisfz1m	266	3	;	;	:
cord-306948-wkisfz1m	266	4	Yu	Yu	NNP
cord-306948-wkisfz1m	266	5	et	et	NNP
cord-306948-wkisfz1m	266	6	al	al	NNP
cord-306948-wkisfz1m	266	7	.	.	NNP
cord-306948-wkisfz1m	266	8	,	,	,
cord-306948-wkisfz1m	266	9	2009	2009	CD
cord-306948-wkisfz1m	266	10	)	)	-RRB-
cord-306948-wkisfz1m	266	11	.	.	.
cord-306948-wkisfz1m	267	1	A	a	DT
cord-306948-wkisfz1m	267	2	series	series	NN
cord-306948-wkisfz1m	267	3	of	of	IN
cord-306948-wkisfz1m	267	4	full	full	JJ
cord-306948-wkisfz1m	267	5	-	-	HYPH
cord-306948-wkisfz1m	267	6	length	length	NN
cord-306948-wkisfz1m	267	7	clones	clone	NNS
cord-306948-wkisfz1m	267	8	were	be	VBD
cord-306948-wkisfz1m	267	9	engineered	engineer	VBN
cord-306948-wkisfz1m	267	10	to	to	TO
cord-306948-wkisfz1m	267	11	separate	separate	VB
cord-306948-wkisfz1m	267	12	overlapping	overlapping	JJ
cord-306948-wkisfz1m	267	13	genes	gene	NNS
cord-306948-wkisfz1m	267	14	for	for	IN
cord-306948-wkisfz1m	267	15	EAV	EAV	NNP
cord-306948-wkisfz1m	267	16	ORFs	ORFs	NNP
cord-306948-wkisfz1m	267	17	4/5	4/5	CD
cord-306948-wkisfz1m	267	18	or	or	CC
cord-306948-wkisfz1m	267	19	ORFs	ORFs	NNP
cord-306948-wkisfz1m	267	20	5/6	5/6	CD
cord-306948-wkisfz1m	267	21	by	by	IN
cord-306948-wkisfz1m	267	22	inserting	insert	VBG
cord-306948-wkisfz1m	267	23	small	small	JJ
cord-306948-wkisfz1m	267	24	additional	additional	JJ
cord-306948-wkisfz1m	267	25	sequences	sequence	NNS
cord-306948-wkisfz1m	267	26	containing	contain	VBG
cord-306948-wkisfz1m	267	27	a	a	DT
cord-306948-wkisfz1m	267	28	termination	termination	NN
cord-306948-wkisfz1m	267	29	codon	codon	NN
cord-306948-wkisfz1m	267	30	for	for	IN
cord-306948-wkisfz1m	267	31	the	the	DT
cord-306948-wkisfz1m	267	32	upstream	upstream	JJ
cord-306948-wkisfz1m	267	33	gene	gene	NN
cord-306948-wkisfz1m	267	34	,	,	,
cord-306948-wkisfz1m	267	35	a	a	DT
cord-306948-wkisfz1m	267	36	unique	unique	JJ
cord-306948-wkisfz1m	267	37	restriction	restriction	NN
cord-306948-wkisfz1m	267	38	site	site	NN
cord-306948-wkisfz1m	267	39	,	,	,
cord-306948-wkisfz1m	267	40	and	and	CC
cord-306948-wkisfz1m	267	41	a	a	DT
cord-306948-wkisfz1m	267	42	translation	translation	NN
cord-306948-wkisfz1m	267	43	initiation	initiation	NN
cord-306948-wkisfz1m	267	44	codon	codon	NN
cord-306948-wkisfz1m	267	45	for	for	IN
cord-306948-wkisfz1m	267	46	the	the	DT
cord-306948-wkisfz1m	267	47	downstream	downstream	JJ
cord-306948-wkisfz1m	267	48	gene	gene	NN
cord-306948-wkisfz1m	267	49	.	.	.
cord-306948-wkisfz1m	268	1	The	the	DT
cord-306948-wkisfz1m	268	2	insertions	insertion	NNS
cord-306948-wkisfz1m	268	3	result	result	VBP
cord-306948-wkisfz1m	268	4	in	in	IN
cord-306948-wkisfz1m	268	5	the	the	DT
cord-306948-wkisfz1m	268	6	functional	functional	JJ
cord-306948-wkisfz1m	268	7	separation	separation	NN
cord-306948-wkisfz1m	268	8	of	of	IN
cord-306948-wkisfz1m	268	9	overlapping	overlap	VBG
cord-306948-wkisfz1m	268	10	ORFs	orf	NNS
cord-306948-wkisfz1m	268	11	,	,	,
cord-306948-wkisfz1m	268	12	and	and	CC
cord-306948-wkisfz1m	268	13	do	do	VBP
cord-306948-wkisfz1m	268	14	not	not	RB
cord-306948-wkisfz1m	268	15	impair	impair	VB
cord-306948-wkisfz1m	268	16	infectivity	infectivity	NN
cord-306948-wkisfz1m	268	17	(	(	-LRB-
cord-306948-wkisfz1m	268	18	de	de	FW
cord-306948-wkisfz1m	268	19	Vries	Vries	NNP
cord-306948-wkisfz1m	268	20	et	et	NNP
cord-306948-wkisfz1m	268	21	al	al	NNP
cord-306948-wkisfz1m	268	22	.	.	NNP
cord-306948-wkisfz1m	268	23	,	,	,
cord-306948-wkisfz1m	268	24	2000	2000	CD
cord-306948-wkisfz1m	268	25	)	)	-RRB-
cord-306948-wkisfz1m	268	26	.	.	.
cord-306948-wkisfz1m	269	1	The	the	DT
cord-306948-wkisfz1m	269	2	ORFs	orfs	NN
cord-306948-wkisfz1m	269	3	5/6	5/6	CD
cord-306948-wkisfz1m	269	4	separation	separation	NN
cord-306948-wkisfz1m	269	5	in	in	IN
cord-306948-wkisfz1m	269	6	genotype	genotype	NN
cord-306948-wkisfz1m	269	7	I	-PRON-	PRP
cord-306948-wkisfz1m	269	8	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	269	9	is	be	VBZ
cord-306948-wkisfz1m	269	10	also	also	RB
cord-306948-wkisfz1m	269	11	possible	possible	JJ
cord-306948-wkisfz1m	269	12	and	and	CC
cord-306948-wkisfz1m	269	13	progeny	progeny	JJ
cord-306948-wkisfz1m	269	14	virus	virus	NN
cord-306948-wkisfz1m	269	15	is	be	VBZ
cord-306948-wkisfz1m	269	16	produced	produce	VBN
cord-306948-wkisfz1m	270	1	(	(	-LRB-
cord-306948-wkisfz1m	270	2	Verheije	Verheije	NNP
cord-306948-wkisfz1m	270	3	et	et	FW
cord-306948-wkisfz1m	270	4	al	al	NNP
cord-306948-wkisfz1m	270	5	.	.	NNP
cord-306948-wkisfz1m	270	6	,	,	,
cord-306948-wkisfz1m	270	7	2002	2002	CD
cord-306948-wkisfz1m	270	8	)	)	-RRB-
cord-306948-wkisfz1m	270	9	.	.	.
cord-306948-wkisfz1m	271	1	For	for	IN
cord-306948-wkisfz1m	271	2	the	the	DT
cord-306948-wkisfz1m	271	3	North	north	JJ
cord-306948-wkisfz1m	271	4	American	american	JJ
cord-306948-wkisfz1m	271	5	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	271	6	,	,	,
cord-306948-wkisfz1m	271	7	restriction	restriction	NN
cord-306948-wkisfz1m	271	8	sites	site	NNS
cord-306948-wkisfz1m	271	9	were	be	VBD
cord-306948-wkisfz1m	271	10	inserted	insert	VBN
cord-306948-wkisfz1m	271	11	between	between	IN
cord-306948-wkisfz1m	271	12	ORFs	ORFs	NNP
cord-306948-wkisfz1m	271	13	1/2	1/2	CD
cord-306948-wkisfz1m	271	14	,	,	,
cord-306948-wkisfz1m	271	15	ORFs	ORFs	NNP
cord-306948-wkisfz1m	271	16	4/5	4/5	CD
cord-306948-wkisfz1m	271	17	,	,	,
cord-306948-wkisfz1m	271	18	ORFs	ORFs	NNP
cord-306948-wkisfz1m	271	19	5/6	5/6	CD
cord-306948-wkisfz1m	271	20	,	,	,
cord-306948-wkisfz1m	271	21	ORFs	ORFs	NNP
cord-306948-wkisfz1m	271	22	6/7	6/7	CD
cord-306948-wkisfz1m	271	23	,	,	,
cord-306948-wkisfz1m	271	24	and	and	CC
cord-306948-wkisfz1m	271	25	ORFs	orfs	NN
cord-306948-wkisfz1m	271	26	7/3	7/3	CD
cord-306948-wkisfz1m	271	27	0	0	CD
cord-306948-wkisfz1m	271	28	-NTR	-ntr	CD
cord-306948-wkisfz1m	271	29	,	,	,
cord-306948-wkisfz1m	271	30	and	and	CC
cord-306948-wkisfz1m	271	31	progeny	progeny	NN
cord-306948-wkisfz1m	271	32	viruses	virus	NNS
cord-306948-wkisfz1m	271	33	are	be	VBP
cord-306948-wkisfz1m	271	34	generated	generate	VBN
cord-306948-wkisfz1m	271	35	from	from	IN
cord-306948-wkisfz1m	271	36	these	these	DT
cord-306948-wkisfz1m	271	37	modifications	modification	NNS
cord-306948-wkisfz1m	271	38	.	.	.
cord-306948-wkisfz1m	272	1	This	this	DT
cord-306948-wkisfz1m	272	2	indicates	indicate	VBZ
cord-306948-wkisfz1m	272	3	that	that	IN
cord-306948-wkisfz1m	272	4	gene	gene	NN
cord-306948-wkisfz1m	272	5	overlap	overlap	NN
cord-306948-wkisfz1m	272	6	is	be	VBZ
cord-306948-wkisfz1m	272	7	dispensable	dispensable	JJ
cord-306948-wkisfz1m	272	8	for	for	IN
cord-306948-wkisfz1m	272	9	infectivity	infectivity	NN
cord-306948-wkisfz1m	272	10	and	and	CC
cord-306948-wkisfz1m	272	11	that	that	DT
cord-306948-wkisfz1m	272	12	separation	separation	NN
cord-306948-wkisfz1m	272	13	of	of	IN
cord-306948-wkisfz1m	272	14	each	each	DT
cord-306948-wkisfz1m	272	15	gene	gene	NN
cord-306948-wkisfz1m	272	16	does	do	VBZ
cord-306948-wkisfz1m	272	17	not	not	RB
cord-306948-wkisfz1m	272	18	interrupt	interrupt	VB
cord-306948-wkisfz1m	272	19	mRNA	mrna	NN
cord-306948-wkisfz1m	272	20	synthesis	synthesis	NN
cord-306948-wkisfz1m	272	21	(	(	-LRB-
cord-306948-wkisfz1m	273	1	Yu	Yu	NNP
cord-306948-wkisfz1m	273	2	et	et	FW
cord-306948-wkisfz1m	273	3	al	al	NNP
cord-306948-wkisfz1m	273	4	.	.	NNP
cord-306948-wkisfz1m	273	5	,	,	,
cord-306948-wkisfz1m	273	6	2009	2009	CD
cord-306948-wkisfz1m	273	7	)	)	-RRB-
cord-306948-wkisfz1m	273	8	.	.	.
cord-306948-wkisfz1m	274	1	The	the	DT
cord-306948-wkisfz1m	274	2	development	development	NN
cord-306948-wkisfz1m	274	3	of	of	IN
cord-306948-wkisfz1m	274	4	infectious	infectious	JJ
cord-306948-wkisfz1m	274	5	clones	clone	NNS
cord-306948-wkisfz1m	274	6	allows	allow	VBZ
cord-306948-wkisfz1m	274	7	the	the	DT
cord-306948-wkisfz1m	274	8	construction	construction	NN
cord-306948-wkisfz1m	274	9	of	of	IN
cord-306948-wkisfz1m	274	10	chimeric	chimeric	JJ
cord-306948-wkisfz1m	274	11	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	274	12	.	.	.
cord-306948-wkisfz1m	275	1	An	an	DT
cord-306948-wkisfz1m	275	2	attempt	attempt	NN
cord-306948-wkisfz1m	275	3	was	be	VBD
cord-306948-wkisfz1m	275	4	made	make	VBN
cord-306948-wkisfz1m	275	5	to	to	TO
cord-306948-wkisfz1m	275	6	swab	swab	VB
cord-306948-wkisfz1m	275	7	the	the	DT
cord-306948-wkisfz1m	275	8	ectodomains	ectodomain	NNS
cord-306948-wkisfz1m	275	9	of	of	IN
cord-306948-wkisfz1m	275	10	GP5	GP5	NNP
cord-306948-wkisfz1m	275	11	and	and	CC
cord-306948-wkisfz1m	275	12	M.	M.	NNP
cord-306948-wkisfz1m	276	1	In	in	IN
cord-306948-wkisfz1m	276	2	engineered	engineer	VBN
cord-306948-wkisfz1m	276	3	chimeric	chimeric	JJ
cord-306948-wkisfz1m	276	4	viruses	virus	NNS
cord-306948-wkisfz1m	276	5	using	use	VBG
cord-306948-wkisfz1m	276	6	the	the	DT
cord-306948-wkisfz1m	276	7	EAV	EAV	NNP
cord-306948-wkisfz1m	276	8	clone	clone	NN
cord-306948-wkisfz1m	276	9	as	as	IN
cord-306948-wkisfz1m	276	10	a	a	DT
cord-306948-wkisfz1m	276	11	backbone	backbone	NN
cord-306948-wkisfz1m	276	12	,	,	,
cord-306948-wkisfz1m	276	13	the	the	DT
cord-306948-wkisfz1m	276	14	ectodomains	ectodomain	NNS
cord-306948-wkisfz1m	276	15	were	be	VBD
cord-306948-wkisfz1m	276	16	replaced	replace	VBN
cord-306948-wkisfz1m	276	17	by	by	IN
cord-306948-wkisfz1m	276	18	corresponding	correspond	VBG
cord-306948-wkisfz1m	276	19	sequences	sequence	NNS
cord-306948-wkisfz1m	276	20	from	from	IN
cord-306948-wkisfz1m	276	21	other	other	JJ
cord-306948-wkisfz1m	276	22	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	276	23	.	.	.
cord-306948-wkisfz1m	277	1	Chimeric	chimeric	JJ
cord-306948-wkisfz1m	277	2	viruses	virus	NNS
cord-306948-wkisfz1m	277	3	containing	contain	VBG
cord-306948-wkisfz1m	277	4	the	the	DT
cord-306948-wkisfz1m	277	5	GP5	GP5	NNP
cord-306948-wkisfz1m	277	6	ectodomain	ectodomain	NNP
cord-306948-wkisfz1m	277	7	from	from	IN
cord-306948-wkisfz1m	277	8	LDV	LDV	NNP
cord-306948-wkisfz1m	277	9	and	and	CC
cord-306948-wkisfz1m	277	10	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	277	11	were	be	VBD
cord-306948-wkisfz1m	277	12	infectious	infectious	JJ
cord-306948-wkisfz1m	277	13	.	.	.
cord-306948-wkisfz1m	278	1	These	these	DT
cord-306948-wkisfz1m	278	2	chimeric	chimeric	JJ
cord-306948-wkisfz1m	278	3	viruses	virus	NNS
cord-306948-wkisfz1m	278	4	however	however	RB
cord-306948-wkisfz1m	278	5	retain	retain	VBP
cord-306948-wkisfz1m	278	6	their	-PRON-	PRP$
cord-306948-wkisfz1m	278	7	cell	cell	NN
cord-306948-wkisfz1m	278	8	tropism	tropism	NN
cord-306948-wkisfz1m	278	9	for	for	IN
cord-306948-wkisfz1m	278	10	BHK-21	BHK-21	NNP
cord-306948-wkisfz1m	278	11	cells	cell	NNS
cord-306948-wkisfz1m	278	12	,	,	,
cord-306948-wkisfz1m	278	13	which	which	WDT
cord-306948-wkisfz1m	278	14	are	be	VBP
cord-306948-wkisfz1m	278	15	susceptible	susceptible	JJ
cord-306948-wkisfz1m	278	16	for	for	IN
cord-306948-wkisfz1m	278	17	EAV	EAV	NNP
cord-306948-wkisfz1m	278	18	but	but	CC
cord-306948-wkisfz1m	278	19	non	non	JJ
cord-306948-wkisfz1m	278	20	-	-	JJ
cord-306948-wkisfz1m	278	21	susceptible	susceptible	JJ
cord-306948-wkisfz1m	278	22	for	for	IN
cord-306948-wkisfz1m	278	23	LDV	LDV	NNP
cord-306948-wkisfz1m	278	24	and	and	CC
cord-306948-wkisfz1m	278	25	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	279	1	(	(	-LRB-
cord-306948-wkisfz1m	279	2	Dobbe	Dobbe	NNP
cord-306948-wkisfz1m	279	3	et	et	FW
cord-306948-wkisfz1m	279	4	al	al	NNP
cord-306948-wkisfz1m	279	5	.	.	NNP
cord-306948-wkisfz1m	279	6	,	,	,
cord-306948-wkisfz1m	279	7	2001	2001	CD
cord-306948-wkisfz1m	279	8	)	)	-RRB-
cord-306948-wkisfz1m	279	9	.	.	.
cord-306948-wkisfz1m	280	1	Replacement	replacement	NN
cord-306948-wkisfz1m	280	2	of	of	IN
cord-306948-wkisfz1m	280	3	the	the	DT
cord-306948-wkisfz1m	280	4	M	M	NNP
cord-306948-wkisfz1m	280	5	ectodomain	ectodomain	NN
cord-306948-wkisfz1m	280	6	of	of	IN
cord-306948-wkisfz1m	280	7	EAV	EAV	NNP
cord-306948-wkisfz1m	280	8	with	with	IN
cord-306948-wkisfz1m	280	9	the	the	DT
cord-306948-wkisfz1m	280	10	corresponding	corresponding	JJ
cord-306948-wkisfz1m	280	11	sequence	sequence	NN
cord-306948-wkisfz1m	280	12	from	from	IN
cord-306948-wkisfz1m	280	13	other	other	JJ
cord-306948-wkisfz1m	280	14	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	280	15	does	do	VBZ
cord-306948-wkisfz1m	280	16	not	not	RB
cord-306948-wkisfz1m	280	17	produce	produce	VB
cord-306948-wkisfz1m	280	18	infectious	infectious	JJ
cord-306948-wkisfz1m	280	19	virus	virus	NN
cord-306948-wkisfz1m	280	20	,	,	,
cord-306948-wkisfz1m	280	21	but	but	CC
cord-306948-wkisfz1m	280	22	replacement	replacement	NN
cord-306948-wkisfz1m	280	23	of	of	IN
cord-306948-wkisfz1m	280	24	the	the	DT
cord-306948-wkisfz1m	280	25	M	M	NNP
cord-306948-wkisfz1m	280	26	ectodomain	ectodomain	NN
cord-306948-wkisfz1m	280	27	of	of	IN
cord-306948-wkisfz1m	280	28	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	280	29	with	with	IN
cord-306948-wkisfz1m	280	30	the	the	DT
cord-306948-wkisfz1m	280	31	corresponding	corresponding	JJ
cord-306948-wkisfz1m	280	32	sequence	sequence	NN
cord-306948-wkisfz1m	280	33	from	from	IN
cord-306948-wkisfz1m	280	34	LDV	LDV	NNP
cord-306948-wkisfz1m	280	35	,	,	,
cord-306948-wkisfz1m	280	36	EAV	EAV	NNP
cord-306948-wkisfz1m	280	37	,	,	,
cord-306948-wkisfz1m	280	38	and	and	CC
cord-306948-wkisfz1m	280	39	genotype	genotype	NN
cord-306948-wkisfz1m	280	40	II	II	NNP
cord-306948-wkisfz1m	280	41	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	280	42	produced	produce	VBD
cord-306948-wkisfz1m	280	43	an	an	DT
cord-306948-wkisfz1m	280	44	infectious	infectious	JJ
cord-306948-wkisfz1m	280	45	virus	virus	NN
cord-306948-wkisfz1m	280	46	.	.	.
cord-306948-wkisfz1m	281	1	Using	use	VBG
cord-306948-wkisfz1m	281	2	the	the	DT
cord-306948-wkisfz1m	281	3	LV	LV	NNP
cord-306948-wkisfz1m	281	4	infectious	infectious	JJ
cord-306948-wkisfz1m	281	5	clone	clone	NN
cord-306948-wkisfz1m	281	6	as	as	IN
cord-306948-wkisfz1m	281	7	a	a	DT
cord-306948-wkisfz1m	281	8	backbone	backbone	NN
cord-306948-wkisfz1m	281	9	,	,	,
cord-306948-wkisfz1m	281	10	substitutions	substitution	NNS
cord-306948-wkisfz1m	281	11	with	with	IN
cord-306948-wkisfz1m	281	12	the	the	DT
cord-306948-wkisfz1m	281	13	EAV	EAV	NNP
cord-306948-wkisfz1m	281	14	M	M	NNP
cord-306948-wkisfz1m	281	15	ectodomain	ectodomain	NNP
cord-306948-wkisfz1m	281	16	or	or	CC
cord-306948-wkisfz1m	281	17	VR-2332	VR-2332	NNP
cord-306948-wkisfz1m	281	18	M	M	NNP
cord-306948-wkisfz1m	281	19	ectodomain	ectodomain	NNP
cord-306948-wkisfz1m	281	20	is	be	VBZ
cord-306948-wkisfz1m	281	21	impossible	impossible	JJ
cord-306948-wkisfz1m	281	22	,	,	,
cord-306948-wkisfz1m	281	23	but	but	CC
cord-306948-wkisfz1m	281	24	removal	removal	NN
cord-306948-wkisfz1m	281	25	of	of	IN
cord-306948-wkisfz1m	281	26	the	the	DT
cord-306948-wkisfz1m	281	27	gene	gene	NN
cord-306948-wkisfz1m	281	28	overlap	overlap	NN
cord-306948-wkisfz1m	281	29	between	between	IN
cord-306948-wkisfz1m	281	30	the	the	DT
cord-306948-wkisfz1m	281	31	M	M	NNP
cord-306948-wkisfz1m	281	32	and	and	CC
cord-306948-wkisfz1m	281	33	GP5	GP5	NNP
cord-306948-wkisfz1m	281	34	genes	gene	NNS
cord-306948-wkisfz1m	281	35	is	be	VBZ
cord-306948-wkisfz1m	281	36	required	require	VBN
cord-306948-wkisfz1m	281	37	before	before	IN
cord-306948-wkisfz1m	281	38	swapping	swap	VBG
cord-306948-wkisfz1m	281	39	,	,	,
cord-306948-wkisfz1m	281	40	indicating	indicate	VBG
cord-306948-wkisfz1m	281	41	that	that	IN
cord-306948-wkisfz1m	281	42	the	the	DT
cord-306948-wkisfz1m	281	43	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	281	44	M	M	NNP
cord-306948-wkisfz1m	281	45	ectodomain	ectodomain	NNP
cord-306948-wkisfz1m	281	46	and	and	CC
cord-306948-wkisfz1m	281	47	EAV	EAV	NNP
cord-306948-wkisfz1m	281	48	M	M	NNP
cord-306948-wkisfz1m	281	49	ectodomain	ectodomain	NNP
cord-306948-wkisfz1m	281	50	are	be	VBP
cord-306948-wkisfz1m	281	51	incompatible	incompatible	JJ
cord-306948-wkisfz1m	281	52	with	with	IN
cord-306948-wkisfz1m	281	53	the	the	DT
cord-306948-wkisfz1m	281	54	remaining	remain	VBG
cord-306948-wkisfz1m	281	55	part	part	NN
cord-306948-wkisfz1m	281	56	of	of	IN
cord-306948-wkisfz1m	281	57	LV	LV	NNP
cord-306948-wkisfz1m	281	58	M.	M.	NNP
cord-306948-wkisfz1m	282	1	It	-PRON-	PRP
cord-306948-wkisfz1m	282	2	is	be	VBZ
cord-306948-wkisfz1m	282	3	also	also	RB
cord-306948-wkisfz1m	282	4	possible	possible	JJ
cord-306948-wkisfz1m	282	5	that	that	IN
cord-306948-wkisfz1m	282	6	unintended	unintended	JJ
cord-306948-wkisfz1m	282	7	mutations	mutation	NNS
cord-306948-wkisfz1m	282	8	may	may	MD
cord-306948-wkisfz1m	282	9	have	have	VB
cord-306948-wkisfz1m	282	10	been	be	VBN
cord-306948-wkisfz1m	282	11	introduced	introduce	VBN
cord-306948-wkisfz1m	282	12	to	to	IN
cord-306948-wkisfz1m	282	13	GP5	GP5	NNP
cord-306948-wkisfz1m	282	14	during	during	IN
cord-306948-wkisfz1m	282	15	the	the	DT
cord-306948-wkisfz1m	282	16	ectodomain	ectodomain	NN
cord-306948-wkisfz1m	282	17	swap	swap	NN
cord-306948-wkisfz1m	282	18	(	(	-LRB-
cord-306948-wkisfz1m	282	19	Verheije	Verheije	NNP
cord-306948-wkisfz1m	282	20	et	et	FW
cord-306948-wkisfz1m	282	21	al	al	NNP
cord-306948-wkisfz1m	282	22	.	.	NNP
cord-306948-wkisfz1m	282	23	,	,	,
cord-306948-wkisfz1m	282	24	2002	2002	CD
cord-306948-wkisfz1m	282	25	)	)	-RRB-
cord-306948-wkisfz1m	282	26	.	.	.
cord-306948-wkisfz1m	283	1	Substitution	substitution	NN
cord-306948-wkisfz1m	283	2	of	of	IN
cord-306948-wkisfz1m	283	3	structural	structural	JJ
cord-306948-wkisfz1m	283	4	genes	gene	NNS
cord-306948-wkisfz1m	283	5	between	between	IN
cord-306948-wkisfz1m	283	6	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	283	7	has	have	VBZ
cord-306948-wkisfz1m	283	8	been	be	VBN
cord-306948-wkisfz1m	283	9	extremely	extremely	RB
cord-306948-wkisfz1m	283	10	useful	useful	JJ
cord-306948-wkisfz1m	283	11	to	to	TO
cord-306948-wkisfz1m	283	12	identify	identify	VB
cord-306948-wkisfz1m	283	13	viral	viral	JJ
cord-306948-wkisfz1m	283	14	factors	factor	NNS
cord-306948-wkisfz1m	283	15	for	for	IN
cord-306948-wkisfz1m	283	16	viral	viral	JJ
cord-306948-wkisfz1m	283	17	tropism	tropism	NN
cord-306948-wkisfz1m	283	18	.	.	.
cord-306948-wkisfz1m	284	1	The	the	DT
cord-306948-wkisfz1m	284	2	substitution	substitution	NN
cord-306948-wkisfz1m	284	3	of	of	IN
cord-306948-wkisfz1m	284	4	GP5	GP5	NNP
cord-306948-wkisfz1m	284	5	or	or	CC
cord-306948-wkisfz1m	284	6	/	/	SYM
cord-306948-wkisfz1m	284	7	and	and	CC
cord-306948-wkisfz1m	284	8	M	M	NNP
cord-306948-wkisfz1m	284	9	do	do	VBP
cord-306948-wkisfz1m	284	10	not	not	RB
cord-306948-wkisfz1m	284	11	alter	alter	VB
cord-306948-wkisfz1m	284	12	their	-PRON-	PRP$
cord-306948-wkisfz1m	284	13	cell	cell	NN
cord-306948-wkisfz1m	284	14	tropism	tropism	NN
cord-306948-wkisfz1m	284	15	(	(	-LRB-
cord-306948-wkisfz1m	284	16	Dobbe	Dobbe	NNP
cord-306948-wkisfz1m	284	17	et	et	FW
cord-306948-wkisfz1m	284	18	al	al	NNP
cord-306948-wkisfz1m	284	19	.	.	NNP
cord-306948-wkisfz1m	284	20	,	,	,
cord-306948-wkisfz1m	284	21	2001	2001	CD
cord-306948-wkisfz1m	284	22	;	;	:
cord-306948-wkisfz1m	285	1	Lu	Lu	NNP
cord-306948-wkisfz1m	285	2	et	et	FW
cord-306948-wkisfz1m	285	3	al	al	NNP
cord-306948-wkisfz1m	285	4	.	.	NNP
cord-306948-wkisfz1m	285	5	,	,	,
cord-306948-wkisfz1m	285	6	2012	2012	CD
cord-306948-wkisfz1m	285	7	;	;	:
cord-306948-wkisfz1m	285	8	Verheije	Verheije	NNP
cord-306948-wkisfz1m	285	9	et	et	FW
cord-306948-wkisfz1m	285	10	al	al	NNP
cord-306948-wkisfz1m	285	11	.	.	NNP
cord-306948-wkisfz1m	285	12	,	,	,
cord-306948-wkisfz1m	285	13	2002	2002	CD
cord-306948-wkisfz1m	285	14	)	)	-RRB-
cord-306948-wkisfz1m	285	15	.	.	.
cord-306948-wkisfz1m	286	1	In	in	IN
cord-306948-wkisfz1m	286	2	contrast	contrast	NN
cord-306948-wkisfz1m	286	3	,	,	,
cord-306948-wkisfz1m	286	4	the	the	DT
cord-306948-wkisfz1m	286	5	substitution	substitution	NN
cord-306948-wkisfz1m	286	6	of	of	IN
cord-306948-wkisfz1m	286	7	minor	minor	JJ
cord-306948-wkisfz1m	286	8	envelope	envelope	NN
cord-306948-wkisfz1m	286	9	proteins	protein	NNS
cord-306948-wkisfz1m	286	10	and	and	CC
cord-306948-wkisfz1m	286	11	E	e	NN
cord-306948-wkisfz1m	286	12	protein	protein	NN
cord-306948-wkisfz1m	286	13	using	use	VBG
cord-306948-wkisfz1m	286	14	the	the	DT
cord-306948-wkisfz1m	286	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	286	16	infectious	infectious	JJ
cord-306948-wkisfz1m	286	17	clone	clone	NN
cord-306948-wkisfz1m	286	18	as	as	IN
cord-306948-wkisfz1m	286	19	a	a	DT
cord-306948-wkisfz1m	286	20	backbone	backbone	NN
cord-306948-wkisfz1m	286	21	allows	allow	VBZ
cord-306948-wkisfz1m	286	22	the	the	DT
cord-306948-wkisfz1m	286	23	chimeric	chimeric	JJ
cord-306948-wkisfz1m	286	24	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	286	25	to	to	TO
cord-306948-wkisfz1m	286	26	acquire	acquire	VB
cord-306948-wkisfz1m	286	27	a	a	DT
cord-306948-wkisfz1m	286	28	broad	broad	JJ
cord-306948-wkisfz1m	286	29	cell	cell	NN
cord-306948-wkisfz1m	286	30	tropism	tropism	NN
cord-306948-wkisfz1m	286	31	but	but	CC
cord-306948-wkisfz1m	286	32	to	to	TO
cord-306948-wkisfz1m	286	33	lose	lose	VB
cord-306948-wkisfz1m	286	34	the	the	DT
cord-306948-wkisfz1m	286	35	ability	ability	NN
cord-306948-wkisfz1m	286	36	to	to	TO
cord-306948-wkisfz1m	286	37	infect	infect	VB
cord-306948-wkisfz1m	286	38	PAMs	pam	NNS
cord-306948-wkisfz1m	286	39	.	.	.
cord-306948-wkisfz1m	287	1	It	-PRON-	PRP
cord-306948-wkisfz1m	287	2	indicates	indicate	VBZ
cord-306948-wkisfz1m	287	3	that	that	IN
cord-306948-wkisfz1m	287	4	the	the	DT
cord-306948-wkisfz1m	287	5	GP2	GP2	NNP
cord-306948-wkisfz1m	287	6	/	/	SYM
cord-306948-wkisfz1m	287	7	GP3	GP3	NNP
cord-306948-wkisfz1m	287	8	/	/	SYM
cord-306948-wkisfz1m	287	9	GP4	GP4	NNP
cord-306948-wkisfz1m	287	10	minor	minor	JJ
cord-306948-wkisfz1m	287	11	proteins	protein	NNS
cord-306948-wkisfz1m	287	12	are	be	VBP
cord-306948-wkisfz1m	287	13	determinants	determinant	NNS
cord-306948-wkisfz1m	287	14	for	for	IN
cord-306948-wkisfz1m	287	15	cell	cell	NN
cord-306948-wkisfz1m	287	16	entry	entry	NN
cord-306948-wkisfz1m	287	17	and	and	CC
cord-306948-wkisfz1m	287	18	tropism	tropism	NN
cord-306948-wkisfz1m	288	1	(	(	-LRB-
cord-306948-wkisfz1m	288	2	Tian	Tian	NNP
cord-306948-wkisfz1m	288	3	et	et	FW
cord-306948-wkisfz1m	288	4	al	al	NNP
cord-306948-wkisfz1m	288	5	.	.	NNP
cord-306948-wkisfz1m	288	6	,	,	,
cord-306948-wkisfz1m	288	7	2011	2011	CD
cord-306948-wkisfz1m	288	8	)	)	-RRB-
cord-306948-wkisfz1m	288	9	.	.	.
cord-306948-wkisfz1m	289	1	Intra	intra	JJ
cord-306948-wkisfz1m	289	2	-	-	JJ
cord-306948-wkisfz1m	289	3	genotypic	genotypic	JJ
cord-306948-wkisfz1m	289	4	or	or	CC
cord-306948-wkisfz1m	289	5	inter	inter	JJ
cord-306948-wkisfz1m	289	6	-	-	JJ
cord-306948-wkisfz1m	289	7	genotypic	genotypic	JJ
cord-306948-wkisfz1m	289	8	gene	gene	NN
cord-306948-wkisfz1m	289	9	-	-	HYPH
cord-306948-wkisfz1m	289	10	swapping	swapping	NN
cord-306948-wkisfz1m	289	11	have	have	VBP
cord-306948-wkisfz1m	289	12	been	be	VBN
cord-306948-wkisfz1m	289	13	conducted	conduct	VBN
cord-306948-wkisfz1m	289	14	between	between	IN
cord-306948-wkisfz1m	289	15	EAV	EAV	NNP
cord-306948-wkisfz1m	289	16	and	and	CC
cord-306948-wkisfz1m	289	17	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	289	18	to	to	TO
cord-306948-wkisfz1m	289	19	study	study	VB
cord-306948-wkisfz1m	289	20	the	the	DT
cord-306948-wkisfz1m	289	21	genetic	genetic	JJ
cord-306948-wkisfz1m	289	22	compatibility	compatibility	NN
cord-306948-wkisfz1m	289	23	and	and	CC
cord-306948-wkisfz1m	289	24	viral	viral	JJ
cord-306948-wkisfz1m	289	25	-	-	HYPH
cord-306948-wkisfz1m	289	26	specific	specific	JJ
cord-306948-wkisfz1m	289	27	phenotypes	phenotype	NNS
cord-306948-wkisfz1m	289	28	,	,	,
cord-306948-wkisfz1m	289	29	including	include	VBG
cord-306948-wkisfz1m	289	30	neutralization	neutralization	NN
cord-306948-wkisfz1m	289	31	,	,	,
cord-306948-wkisfz1m	289	32	virulence	virulence	NN
cord-306948-wkisfz1m	289	33	,	,	,
cord-306948-wkisfz1m	289	34	and	and	CC
cord-306948-wkisfz1m	289	35	pathogenesis	pathogenesis	NN
cord-306948-wkisfz1m	289	36	.	.	.
cord-306948-wkisfz1m	290	1	For	for	IN
cord-306948-wkisfz1m	290	2	neutralization	neutralization	NN
cord-306948-wkisfz1m	290	3	,	,	,
cord-306948-wkisfz1m	290	4	9	9	CD
cord-306948-wkisfz1m	290	5	chimeric	chimeric	JJ
cord-306948-wkisfz1m	290	6	EAVs	eav	NNS
cord-306948-wkisfz1m	290	7	were	be	VBD
cord-306948-wkisfz1m	290	8	generated	generate	VBN
cord-306948-wkisfz1m	290	9	in	in	IN
cord-306948-wkisfz1m	290	10	which	which	WDT
cord-306948-wkisfz1m	290	11	each	each	DT
cord-306948-wkisfz1m	290	12	construct	construct	VBP
cord-306948-wkisfz1m	290	13	contained	contain	VBN
cord-306948-wkisfz1m	290	14	individual	individual	JJ
cord-306948-wkisfz1m	290	15	ORF5	ORF5	NNP
cord-306948-wkisfz1m	290	16	from	from	IN
cord-306948-wkisfz1m	290	17	different	different	JJ
cord-306948-wkisfz1m	290	18	isolates	isolate	NNS
cord-306948-wkisfz1m	290	19	(	(	-LRB-
cord-306948-wkisfz1m	290	20	Balasuriya	Balasuriya	NNP
cord-306948-wkisfz1m	290	21	et	et	NNP
cord-306948-wkisfz1m	290	22	al	al	NNP
cord-306948-wkisfz1m	290	23	.	.	NNP
cord-306948-wkisfz1m	290	24	,	,	,
cord-306948-wkisfz1m	290	25	2004	2004	CD
cord-306948-wkisfz1m	290	26	)	)	-RRB-
cord-306948-wkisfz1m	290	27	.	.	.
cord-306948-wkisfz1m	291	1	Also	also	RB
cord-306948-wkisfz1m	291	2	,	,	,
cord-306948-wkisfz1m	291	3	the	the	DT
cord-306948-wkisfz1m	291	4	role	role	NN
cord-306948-wkisfz1m	291	5	of	of	IN
cord-306948-wkisfz1m	291	6	individual	individual	JJ
cord-306948-wkisfz1m	291	7	envelope	envelope	NN
cord-306948-wkisfz1m	291	8	proteins	protein	NNS
cord-306948-wkisfz1m	291	9	of	of	IN
cord-306948-wkisfz1m	291	10	GP2	GP2	NNP
cord-306948-wkisfz1m	291	11	through	through	IN
cord-306948-wkisfz1m	291	12	M	M	NNP
cord-306948-wkisfz1m	291	13	for	for	IN
cord-306948-wkisfz1m	291	14	cross	cross	NN
cord-306948-wkisfz1m	291	15	-	-	NN
cord-306948-wkisfz1m	291	16	neutralization	neutralization	NN
cord-306948-wkisfz1m	291	17	was	be	VBD
cord-306948-wkisfz1m	291	18	studied	study	VBN
cord-306948-wkisfz1m	291	19	using	use	VBG
cord-306948-wkisfz1m	291	20	the	the	DT
cord-306948-wkisfz1m	291	21	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	291	22	infectious	infectious	JJ
cord-306948-wkisfz1m	291	23	clone	clone	NN
cord-306948-wkisfz1m	291	24	as	as	IN
cord-306948-wkisfz1m	291	25	a	a	DT
cord-306948-wkisfz1m	291	26	backbone	backbone	NN
cord-306948-wkisfz1m	291	27	(	(	-LRB-
cord-306948-wkisfz1m	291	28	Kim	Kim	NNP
cord-306948-wkisfz1m	291	29	and	and	CC
cord-306948-wkisfz1m	291	30	Yoon	Yoon	NNP
cord-306948-wkisfz1m	291	31	,	,	,
cord-306948-wkisfz1m	291	32	2008	2008	CD
cord-306948-wkisfz1m	291	33	)	)	-RRB-
cord-306948-wkisfz1m	291	34	.	.	.
cord-306948-wkisfz1m	292	1	The	the	DT
cord-306948-wkisfz1m	292	2	PRRSV-01	PRRSV-01	NNPS
cord-306948-wkisfz1m	292	3	strain	strain	NN
cord-306948-wkisfz1m	292	4	is	be	VBZ
cord-306948-wkisfz1m	292	5	highly	highly	RB
cord-306948-wkisfz1m	292	6	susceptible	susceptible	JJ
cord-306948-wkisfz1m	292	7	to	to	IN
cord-306948-wkisfz1m	292	8	serum	serum	NN
cord-306948-wkisfz1m	292	9	neutralization	neutralization	NN
cord-306948-wkisfz1m	292	10	and	and	CC
cord-306948-wkisfz1m	292	11	induces	induce	VBZ
cord-306948-wkisfz1m	292	12	atypically	atypically	RB
cord-306948-wkisfz1m	292	13	rapid	rapid	JJ
cord-306948-wkisfz1m	292	14	and	and	CC
cord-306948-wkisfz1m	292	15	robust	robust	JJ
cord-306948-wkisfz1m	292	16	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	292	17	antibodies	antibody	NNS
cord-306948-wkisfz1m	292	18	in	in	IN
cord-306948-wkisfz1m	292	19	pigs	pig	NNS
cord-306948-wkisfz1m	292	20	.	.	.
cord-306948-wkisfz1m	293	1	Analysis	analysis	NN
cord-306948-wkisfz1m	293	2	of	of	IN
cord-306948-wkisfz1m	293	3	structural	structural	JJ
cord-306948-wkisfz1m	293	4	genes	gene	NNS
cord-306948-wkisfz1m	293	5	of	of	IN
cord-306948-wkisfz1m	293	6	PRRSV-01	PRRSV-01	NNPS
cord-306948-wkisfz1m	293	7	reveals	reveal	VBZ
cord-306948-wkisfz1m	293	8	the	the	DT
cord-306948-wkisfz1m	293	9	absence	absence	NN
cord-306948-wkisfz1m	293	10	of	of	IN
cord-306948-wkisfz1m	293	11	two	two	CD
cord-306948-wkisfz1m	293	12	N	n	CD
cord-306948-wkisfz1m	293	13	-	-	HYPH
cord-306948-wkisfz1m	293	14	linked	link	VBN
cord-306948-wkisfz1m	293	15	glycosylation	glycosylation	NN
cord-306948-wkisfz1m	293	16	sites	site	NNS
cord-306948-wkisfz1m	293	17	each	each	DT
cord-306948-wkisfz1m	293	18	in	in	IN
cord-306948-wkisfz1m	293	19	GP3	GP3	NNP
cord-306948-wkisfz1m	293	20	and	and	CC
cord-306948-wkisfz1m	293	21	GP5	GP5	NNP
cord-306948-wkisfz1m	293	22	.	.	.
cord-306948-wkisfz1m	294	1	The	the	DT
cord-306948-wkisfz1m	294	2	significance	significance	NN
cord-306948-wkisfz1m	294	3	of	of	IN
cord-306948-wkisfz1m	294	4	missing	miss	VBG
cord-306948-wkisfz1m	294	5	glycans	glycan	NNS
cord-306948-wkisfz1m	294	6	for	for	IN
cord-306948-wkisfz1m	294	7	neutralization	neutralization	NN
cord-306948-wkisfz1m	294	8	has	have	VBZ
cord-306948-wkisfz1m	294	9	been	be	VBN
cord-306948-wkisfz1m	294	10	determined	determine	VBN
cord-306948-wkisfz1m	294	11	by	by	IN
cord-306948-wkisfz1m	294	12	replacing	replace	VBG
cord-306948-wkisfz1m	294	13	GP3	GP3	NNP
cord-306948-wkisfz1m	294	14	and	and	CC
cord-306948-wkisfz1m	294	15	GP5	GP5	NNP
cord-306948-wkisfz1m	294	16	genes	gene	NNS
cord-306948-wkisfz1m	294	17	from	from	IN
cord-306948-wkisfz1m	294	18	PRRSV-01	PRRSV-01	NNP
cord-306948-wkisfz1m	294	19	(	(	-LRB-
cord-306948-wkisfz1m	294	20	Vu	Vu	NNP
cord-306948-wkisfz1m	294	21	et	et	FW
cord-306948-wkisfz1m	294	22	al	al	NNP
cord-306948-wkisfz1m	294	23	.	.	NNP
cord-306948-wkisfz1m	294	24	,	,	,
cord-306948-wkisfz1m	294	25	2011	2011	CD
cord-306948-wkisfz1m	294	26	)	)	-RRB-
cord-306948-wkisfz1m	294	27	.	.	.
cord-306948-wkisfz1m	295	1	The	the	DT
cord-306948-wkisfz1m	295	2	major	major	JJ
cord-306948-wkisfz1m	295	3	virulence	virulence	NN
cord-306948-wkisfz1m	295	4	determinants	determinant	NNS
cord-306948-wkisfz1m	295	5	have	have	VBP
cord-306948-wkisfz1m	295	6	also	also	RB
cord-306948-wkisfz1m	295	7	been	be	VBN
cord-306948-wkisfz1m	295	8	identified	identify	VBN
cord-306948-wkisfz1m	295	9	by	by	IN
cord-306948-wkisfz1m	295	10	gene	gene	NN
cord-306948-wkisfz1m	295	11	swapping	swap	VBG
cord-306948-wkisfz1m	295	12	experiments	experiment	NNS
cord-306948-wkisfz1m	295	13	to	to	TO
cord-306948-wkisfz1m	295	14	locate	locate	VB
cord-306948-wkisfz1m	295	15	in	in	IN
cord-306948-wkisfz1m	295	16	nsp3	nsp3	NNS
cord-306948-wkisfz1m	295	17	through	through	IN
cord-306948-wkisfz1m	295	18	nsp8	nsp8	NN
cord-306948-wkisfz1m	295	19	and	and	CC
cord-306948-wkisfz1m	295	20	GP5	GP5	NNP
cord-306948-wkisfz1m	295	21	.	.	.
cord-306948-wkisfz1m	296	1	Highly	highly	RB
cord-306948-wkisfz1m	296	2	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	296	3	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	296	4	contains	contain	VBZ
cord-306948-wkisfz1m	296	5	the	the	DT
cord-306948-wkisfz1m	296	6	30	30	CD
cord-306948-wkisfz1m	296	7	aa	aa	NNP
cord-306948-wkisfz1m	296	8	deletion	deletion	NN
cord-306948-wkisfz1m	296	9	in	in	IN
cord-306948-wkisfz1m	296	10	nsp2	nsp2	NNP
cord-306948-wkisfz1m	296	11	sequence	sequence	NN
cord-306948-wkisfz1m	297	1	(	(	-LRB-
cord-306948-wkisfz1m	297	2	Tian	Tian	NNP
cord-306948-wkisfz1m	297	3	et	et	FW
cord-306948-wkisfz1m	297	4	al	al	NNP
cord-306948-wkisfz1m	297	5	.	.	NNP
cord-306948-wkisfz1m	297	6	,	,	,
cord-306948-wkisfz1m	297	7	2007	2007	CD
cord-306948-wkisfz1m	297	8	)	)	-RRB-
cord-306948-wkisfz1m	297	9	.	.	.
cord-306948-wkisfz1m	298	1	By	by	IN
cord-306948-wkisfz1m	298	2	gene	gene	NN
cord-306948-wkisfz1m	298	3	swapping	swapping	NN
cord-306948-wkisfz1m	298	4	studies	study	NNS
cord-306948-wkisfz1m	298	5	using	use	VBG
cord-306948-wkisfz1m	298	6	nsp2	nsp2	NNP
cord-306948-wkisfz1m	298	7	from	from	IN
cord-306948-wkisfz1m	298	8	an	an	DT
cord-306948-wkisfz1m	298	9	avirulent	avirulent	NN
cord-306948-wkisfz1m	298	10	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	298	11	,	,	,
cord-306948-wkisfz1m	298	12	the	the	DT
cord-306948-wkisfz1m	298	13	deletion	deletion	NN
cord-306948-wkisfz1m	298	14	in	in	IN
cord-306948-wkisfz1m	298	15	nsp2	nsp2	NNP
cord-306948-wkisfz1m	298	16	was	be	VBD
cord-306948-wkisfz1m	298	17	shown	show	VBN
cord-306948-wkisfz1m	298	18	to	to	TO
cord-306948-wkisfz1m	298	19	be	be	VB
cord-306948-wkisfz1m	298	20	irrelevant	irrelevant	JJ
cord-306948-wkisfz1m	298	21	to	to	IN
cord-306948-wkisfz1m	298	22	virulence	virulence	NN
cord-306948-wkisfz1m	298	23	and	and	CC
cord-306948-wkisfz1m	298	24	pathogenicity	pathogenicity	NN
cord-306948-wkisfz1m	298	25	(	(	-LRB-
cord-306948-wkisfz1m	298	26	Zhou	Zhou	NNP
cord-306948-wkisfz1m	298	27	et	et	NNP
cord-306948-wkisfz1m	298	28	al	al	NNP
cord-306948-wkisfz1m	298	29	.	.	NNP
cord-306948-wkisfz1m	298	30	,	,	,
cord-306948-wkisfz1m	298	31	2009	2009	CD
cord-306948-wkisfz1m	298	32	)	)	-RRB-
cord-306948-wkisfz1m	298	33	.	.	.
cord-306948-wkisfz1m	299	1	A	a	DT
cord-306948-wkisfz1m	299	2	recent	recent	JJ
cord-306948-wkisfz1m	299	3	study	study	NN
cord-306948-wkisfz1m	299	4	identified	identify	VBD
cord-306948-wkisfz1m	299	5	nsp9-and	nsp9-and	DT
cord-306948-wkisfz1m	299	6	nsp10-coding	nsp10-coding	DT
cord-306948-wkisfz1m	299	7	regions	region	NNS
cord-306948-wkisfz1m	299	8	together	together	RB
cord-306948-wkisfz1m	299	9	were	be	VBD
cord-306948-wkisfz1m	299	10	essential	essential	JJ
cord-306948-wkisfz1m	299	11	for	for	IN
cord-306948-wkisfz1m	299	12	increased	increase	VBN
cord-306948-wkisfz1m	299	13	pathogenicity	pathogenicity	NN
cord-306948-wkisfz1m	299	14	and	and	CC
cord-306948-wkisfz1m	299	15	fatal	fatal	JJ
cord-306948-wkisfz1m	299	16	virulence	virulence	NN
cord-306948-wkisfz1m	299	17	for	for	IN
cord-306948-wkisfz1m	299	18	HP	HP	NNP
cord-306948-wkisfz1m	299	19	-	-	HYPH
cord-306948-wkisfz1m	299	20	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	299	21	by	by	IN
cord-306948-wkisfz1m	299	22	swapping	swap	VBG
cord-306948-wkisfz1m	299	23	these	these	DT
cord-306948-wkisfz1m	299	24	regions	region	NNS
cord-306948-wkisfz1m	299	25	between	between	IN
cord-306948-wkisfz1m	299	26	the	the	DT
cord-306948-wkisfz1m	299	27	highly	highly	RB
cord-306948-wkisfz1m	299	28	and	and	CC
cord-306948-wkisfz1m	299	29	low	low	JJ
cord-306948-wkisfz1m	299	30	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	299	31	strains	strain	NNS
cord-306948-wkisfz1m	299	32	(	(	-LRB-
cord-306948-wkisfz1m	299	33	Li	Li	NNP
cord-306948-wkisfz1m	299	34	et	et	NNP
cord-306948-wkisfz1m	299	35	al	al	NNP
cord-306948-wkisfz1m	299	36	.	.	NNP
cord-306948-wkisfz1m	299	37	,	,	,
cord-306948-wkisfz1m	299	38	2014	2014	CD
cord-306948-wkisfz1m	299	39	)	)	-RRB-
cord-306948-wkisfz1m	299	40	.	.	.
cord-306948-wkisfz1m	300	1	The	the	DT
cord-306948-wkisfz1m	300	2	intergenotypic	intergenotypic	JJ
cord-306948-wkisfz1m	300	3	5	5	CD
cord-306948-wkisfz1m	300	4	0	0	CD
cord-306948-wkisfz1m	300	5	-UTR	-utr	NN
cord-306948-wkisfz1m	300	6	swap	swap	NN
cord-306948-wkisfz1m	300	7	between	between	IN
cord-306948-wkisfz1m	300	8	genotypes	genotype	NNS
cord-306948-wkisfz1m	300	9	I	-PRON-	PRP
cord-306948-wkisfz1m	300	10	and	and	CC
cord-306948-wkisfz1m	300	11	II	II	NNP
cord-306948-wkisfz1m	300	12	was	be	VBD
cord-306948-wkisfz1m	300	13	investigated	investigate	VBN
cord-306948-wkisfz1m	300	14	and	and	CC
cord-306948-wkisfz1m	300	15	shows	show	VBZ
cord-306948-wkisfz1m	300	16	that	that	IN
cord-306948-wkisfz1m	300	17	the	the	DT
cord-306948-wkisfz1m	300	18	5	5	CD
cord-306948-wkisfz1m	300	19	0	0	CD
cord-306948-wkisfz1m	300	20	-UTR	-utr	NN
cord-306948-wkisfz1m	300	21	of	of	IN
cord-306948-wkisfz1m	300	22	genotype	genotype	NN
cord-306948-wkisfz1m	300	23	II	II	NNP
cord-306948-wkisfz1m	300	24	may	may	MD
cord-306948-wkisfz1m	300	25	be	be	VB
cord-306948-wkisfz1m	300	26	substituted	substitute	VBN
cord-306948-wkisfz1m	300	27	with	with	IN
cord-306948-wkisfz1m	300	28	the	the	DT
cord-306948-wkisfz1m	300	29	corresponding	corresponding	JJ
cord-306948-wkisfz1m	300	30	sequence	sequence	NN
cord-306948-wkisfz1m	300	31	from	from	IN
cord-306948-wkisfz1m	300	32	genotype	genotype	NN
cord-306948-wkisfz1m	300	33	I	I	NNP
cord-306948-wkisfz1m	300	34	,	,	,
cord-306948-wkisfz1m	300	35	while	while	IN
cord-306948-wkisfz1m	300	36	the	the	DT
cord-306948-wkisfz1m	300	37	substitution	substitution	NN
cord-306948-wkisfz1m	300	38	of	of	IN
cord-306948-wkisfz1m	300	39	5	5	CD
cord-306948-wkisfz1m	300	40	0	0	CD
cord-306948-wkisfz1m	300	41	-UTR	-utr	NN
cord-306948-wkisfz1m	300	42	of	of	IN
cord-306948-wkisfz1m	300	43	genotype	genotype	NN
cord-306948-wkisfz1m	300	44	I	-PRON-	PRP
cord-306948-wkisfz1m	300	45	with	with	IN
cord-306948-wkisfz1m	300	46	its	-PRON-	PRP$
cord-306948-wkisfz1m	300	47	corresponding	corresponding	JJ
cord-306948-wkisfz1m	300	48	sequence	sequence	NN
cord-306948-wkisfz1m	300	49	from	from	IN
cord-306948-wkisfz1m	300	50	genotype	genotype	NN
cord-306948-wkisfz1m	300	51	II	II	NNP
cord-306948-wkisfz1m	300	52	is	be	VBZ
cord-306948-wkisfz1m	300	53	lethal	lethal	JJ
cord-306948-wkisfz1m	300	54	(	(	-LRB-
cord-306948-wkisfz1m	300	55	Gao	Gao	NNP
cord-306948-wkisfz1m	300	56	et	et	NNP
cord-306948-wkisfz1m	300	57	al	al	NNP
cord-306948-wkisfz1m	300	58	.	.	NNP
cord-306948-wkisfz1m	300	59	,	,	,
cord-306948-wkisfz1m	300	60	2013	2013	CD
cord-306948-wkisfz1m	300	61	)	)	-RRB-
cord-306948-wkisfz1m	300	62	.	.	.
cord-306948-wkisfz1m	301	1	Using	use	VBG
cord-306948-wkisfz1m	301	2	this	this	DT
cord-306948-wkisfz1m	301	3	approach	approach	NN
cord-306948-wkisfz1m	301	4	,	,	,
cord-306948-wkisfz1m	301	5	the	the	DT
cord-306948-wkisfz1m	301	6	envelope	envelope	NN
cord-306948-wkisfz1m	301	7	proteins	protein	NNS
cord-306948-wkisfz1m	301	8	representing	represent	VBG
cord-306948-wkisfz1m	301	9	GP2	GP2	NNP
cord-306948-wkisfz1m	301	10	through	through	IN
cord-306948-wkisfz1m	301	11	GP5	GP5	NNP
cord-306948-wkisfz1m	301	12	of	of	IN
cord-306948-wkisfz1m	301	13	genotype	genotype	NN
cord-306948-wkisfz1m	301	14	I	-PRON-	PRP
cord-306948-wkisfz1m	301	15	are	be	VBP
cord-306948-wkisfz1m	301	16	shown	show	VBN
cord-306948-wkisfz1m	301	17	to	to	TO
cord-306948-wkisfz1m	301	18	be	be	VB
cord-306948-wkisfz1m	301	19	fully	fully	RB
cord-306948-wkisfz1m	301	20	functional	functional	JJ
cord-306948-wkisfz1m	301	21	for	for	IN
cord-306948-wkisfz1m	301	22	genotype	genotype	NN
cord-306948-wkisfz1m	301	23	II	II	NNP
cord-306948-wkisfz1m	301	24	when	when	WRB
cord-306948-wkisfz1m	301	25	using	use	VBG
cord-306948-wkisfz1m	301	26	genotype	genotype	NN
cord-306948-wkisfz1m	301	27	II	II	NNP
cord-306948-wkisfz1m	301	28	as	as	IN
cord-306948-wkisfz1m	301	29	a	a	DT
cord-306948-wkisfz1m	301	30	backbone	backbone	NN
cord-306948-wkisfz1m	301	31	(	(	-LRB-
cord-306948-wkisfz1m	301	32	Tian	Tian	NNP
cord-306948-wkisfz1m	301	33	et	et	FW
cord-306948-wkisfz1m	301	34	al	al	NNP
cord-306948-wkisfz1m	301	35	.	.	NNP
cord-306948-wkisfz1m	301	36	,	,	,
cord-306948-wkisfz1m	301	37	2011	2011	CD
cord-306948-wkisfz1m	301	38	)	)	-RRB-
cord-306948-wkisfz1m	301	39	.	.	.
cord-306948-wkisfz1m	302	1	A	a	DT
cord-306948-wkisfz1m	302	2	random	random	JJ
cord-306948-wkisfz1m	302	3	sequence	sequence	NN
cord-306948-wkisfz1m	302	4	shuffling	shuffling	NN
cord-306948-wkisfz1m	302	5	has	have	VBZ
cord-306948-wkisfz1m	302	6	been	be	VBN
cord-306948-wkisfz1m	302	7	employed	employ	VBN
cord-306948-wkisfz1m	302	8	to	to	TO
cord-306948-wkisfz1m	302	9	generate	generate	VB
cord-306948-wkisfz1m	302	10	immunologic	immunologic	JJ
cord-306948-wkisfz1m	302	11	variants	variant	NNS
cord-306948-wkisfz1m	302	12	of	of	IN
cord-306948-wkisfz1m	302	13	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	302	14	Zhou	Zhou	NNP
cord-306948-wkisfz1m	302	15	et	et	NNP
cord-306948-wkisfz1m	302	16	al	al	NNP
cord-306948-wkisfz1m	302	17	.	.	.
cord-306948-wkisfz1m	303	1	,	,	,
cord-306948-wkisfz1m	303	2	2012	2012	CD
cord-306948-wkisfz1m	303	3	Zhou	Zhou	NNP
cord-306948-wkisfz1m	303	4	et	et	NNP
cord-306948-wkisfz1m	303	5	al	al	NNP
cord-306948-wkisfz1m	303	6	.	.	.
cord-306948-wkisfz1m	304	1	,	,	,
cord-306948-wkisfz1m	304	2	,	,	,
cord-306948-wkisfz1m	304	3	2013	2013	CD
cord-306948-wkisfz1m	304	4	.	.	.
cord-306948-wkisfz1m	305	1	GP3	GP3	NNP
cord-306948-wkisfz1m	305	2	sequences	sequence	NNS
cord-306948-wkisfz1m	305	3	representing	represent	VBG
cord-306948-wkisfz1m	305	4	immunologically	immunologically	RB
cord-306948-wkisfz1m	305	5	diverse	diverse	JJ
cord-306948-wkisfz1m	305	6	strains	strain	NNS
cord-306948-wkisfz1m	305	7	of	of	IN
cord-306948-wkisfz1m	305	8	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	305	9	are	be	VBP
cord-306948-wkisfz1m	305	10	randomly	randomly	RB
cord-306948-wkisfz1m	305	11	shuffled	shuffle	VBN
cord-306948-wkisfz1m	305	12	,	,	,
cord-306948-wkisfz1m	305	13	and	and	CC
cord-306948-wkisfz1m	305	14	the	the	DT
cord-306948-wkisfz1m	305	15	shuffled	shuffle	VBN
cord-306948-wkisfz1m	305	16	gene	gene	NN
cord-306948-wkisfz1m	305	17	is	be	VBZ
cord-306948-wkisfz1m	305	18	incorporated	incorporate	VBN
cord-306948-wkisfz1m	305	19	in	in	IN
cord-306948-wkisfz1m	305	20	the	the	DT
cord-306948-wkisfz1m	305	21	infectious	infectious	JJ
cord-306948-wkisfz1m	305	22	clone	clone	NN
cord-306948-wkisfz1m	305	23	to	to	TO
cord-306948-wkisfz1m	305	24	generate	generate	VB
cord-306948-wkisfz1m	305	25	a	a	DT
cord-306948-wkisfz1m	305	26	new	new	JJ
cord-306948-wkisfz1m	305	27	virus	virus	NN
cord-306948-wkisfz1m	305	28	that	that	WDT
cord-306948-wkisfz1m	305	29	contains	contain	VBZ
cord-306948-wkisfz1m	305	30	a	a	DT
cord-306948-wkisfz1m	305	31	new	new	JJ
cord-306948-wkisfz1m	305	32	GP3	GP3	NNP
cord-306948-wkisfz1m	305	33	gene	gene	NN
cord-306948-wkisfz1m	305	34	,	,	,
cord-306948-wkisfz1m	305	35	which	which	WDT
cord-306948-wkisfz1m	305	36	may	may	MD
cord-306948-wkisfz1m	305	37	improve	improve	VB
cord-306948-wkisfz1m	305	38	the	the	DT
cord-306948-wkisfz1m	305	39	cross	cross	NN
cord-306948-wkisfz1m	305	40	neutralization	neutralization	NN
cord-306948-wkisfz1m	305	41	.	.	.
cord-306948-wkisfz1m	306	1	The	the	DT
cord-306948-wkisfz1m	306	2	breeding	breeding	NN
cord-306948-wkisfz1m	306	3	of	of	IN
cord-306948-wkisfz1m	306	4	GP4	GP4	NNP
cord-306948-wkisfz1m	306	5	and	and	CC
cord-306948-wkisfz1m	306	6	M	M	NNP
cord-306948-wkisfz1m	306	7	have	have	VBP
cord-306948-wkisfz1m	306	8	also	also	RB
cord-306948-wkisfz1m	306	9	been	be	VBN
cord-306948-wkisfz1m	306	10	tried	try	VBN
cord-306948-wkisfz1m	306	11	,	,	,
cord-306948-wkisfz1m	306	12	and	and	CC
cord-306948-wkisfz1m	306	13	the	the	DT
cord-306948-wkisfz1m	306	14	rescued	rescue	VBN
cord-306948-wkisfz1m	306	15	virus	virus	NN
cord-306948-wkisfz1m	306	16	induces	induce	VBZ
cord-306948-wkisfz1m	306	17	a	a	DT
cord-306948-wkisfz1m	306	18	broad	broad	JJ
cord-306948-wkisfz1m	306	19	spectrum	spectrum	NN
cord-306948-wkisfz1m	306	20	of	of	IN
cord-306948-wkisfz1m	306	21	cross	cross	NN
cord-306948-wkisfz1m	306	22	-	-	JJ
cord-306948-wkisfz1m	306	23	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	306	24	antibodies	antibody	NNS
cord-306948-wkisfz1m	306	25	.	.	.
cord-306948-wkisfz1m	307	1	The	the	DT
cord-306948-wkisfz1m	307	2	GP5	GP5	NNP
cord-306948-wkisfz1m	307	3	sequence	sequence	NN
cord-306948-wkisfz1m	307	4	from	from	IN
cord-306948-wkisfz1m	307	5	7	7	CD
cord-306948-wkisfz1m	307	6	genetically	genetically	RB
cord-306948-wkisfz1m	307	7	diverse	diverse	JJ
cord-306948-wkisfz1m	307	8	strains	strain	NNS
cord-306948-wkisfz1m	307	9	of	of	IN
cord-306948-wkisfz1m	307	10	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	307	11	and	and	CC
cord-306948-wkisfz1m	307	12	the	the	DT
cord-306948-wkisfz1m	307	13	GP5-M	GP5-M	NNP
cord-306948-wkisfz1m	307	14	sequence	sequence	NN
cord-306948-wkisfz1m	307	15	from	from	IN
cord-306948-wkisfz1m	307	16	6	6	CD
cord-306948-wkisfz1m	307	17	different	different	JJ
cord-306948-wkisfz1m	307	18	strains	strain	NNS
cord-306948-wkisfz1m	307	19	were	be	VBD
cord-306948-wkisfz1m	307	20	subjected	subject	VBN
cord-306948-wkisfz1m	307	21	to	to	IN
cord-306948-wkisfz1m	307	22	breeding	breeding	NN
cord-306948-wkisfz1m	307	23	,	,	,
cord-306948-wkisfz1m	307	24	and	and	CC
cord-306948-wkisfz1m	307	25	the	the	DT
cord-306948-wkisfz1m	307	26	shuffled	shuffle	VBN
cord-306948-wkisfz1m	307	27	genes	gene	NNS
cord-306948-wkisfz1m	307	28	were	be	VBD
cord-306948-wkisfz1m	307	29	cloned	clone	VBN
cord-306948-wkisfz1m	307	30	in	in	IN
cord-306948-wkisfz1m	307	31	infectious	infectious	JJ
cord-306948-wkisfz1m	307	32	clones	clone	NNS
cord-306948-wkisfz1m	307	33	for	for	IN
cord-306948-wkisfz1m	307	34	the	the	DT
cord-306948-wkisfz1m	307	35	generation	generation	NN
cord-306948-wkisfz1m	307	36	of	of	IN
cord-306948-wkisfz1m	307	37	new	new	JJ
cord-306948-wkisfz1m	307	38	viruses	virus	NNS
cord-306948-wkisfz1m	307	39	.	.	.
cord-306948-wkisfz1m	308	1	Two	two	CD
cord-306948-wkisfz1m	308	2	representative	representative	JJ
cord-306948-wkisfz1m	308	3	chimeric	chimeric	JJ
cord-306948-wkisfz1m	308	4	viruses	virus	NNS
cord-306948-wkisfz1m	308	5	,	,	,
cord-306948-wkisfz1m	308	6	DS722	DS722	NNP
cord-306948-wkisfz1m	308	7	by	by	IN
cord-306948-wkisfz1m	308	8	GP5	GP5	NNP
cord-306948-wkisfz1m	308	9	shuffling	shuffle	VBG
cord-306948-wkisfz1m	308	10	and	and	CC
cord-306948-wkisfz1m	308	11	DS5M3	DS5M3	VBN
cord-306948-wkisfz1m	308	12	by	by	IN
cord-306948-wkisfz1m	308	13	GP5-M	GP5-M	NNS
cord-306948-wkisfz1m	308	14	shuffling	shuffle	VBG
cord-306948-wkisfz1m	308	15	,	,	,
cord-306948-wkisfz1m	308	16	were	be	VBD
cord-306948-wkisfz1m	308	17	found	find	VBN
cord-306948-wkisfz1m	308	18	to	to	TO
cord-306948-wkisfz1m	308	19	be	be	VB
cord-306948-wkisfz1m	308	20	clinically	clinically	RB
cord-306948-wkisfz1m	308	21	attenuated	attenuated	JJ
cord-306948-wkisfz1m	308	22	.	.	.
cord-306948-wkisfz1m	309	1	This	this	DT
cord-306948-wkisfz1m	309	2	approach	approach	NN
cord-306948-wkisfz1m	309	3	allows	allow	VBZ
cord-306948-wkisfz1m	309	4	rapid	rapid	JJ
cord-306948-wkisfz1m	309	5	generation	generation	NN
cord-306948-wkisfz1m	309	6	of	of	IN
cord-306948-wkisfz1m	309	7	an	an	DT
cord-306948-wkisfz1m	309	8	attenuated	attenuated	JJ
cord-306948-wkisfz1m	309	9	virus	virus	NN
cord-306948-wkisfz1m	309	10	and	and	CC
cord-306948-wkisfz1m	309	11	may	may	MD
cord-306948-wkisfz1m	309	12	be	be	VB
cord-306948-wkisfz1m	309	13	useful	useful	JJ
cord-306948-wkisfz1m	309	14	for	for	IN
cord-306948-wkisfz1m	309	15	vaccine	vaccine	NN
cord-306948-wkisfz1m	309	16	development	development	NN
cord-306948-wkisfz1m	309	17	for	for	IN
cord-306948-wkisfz1m	309	18	antigenetically	antigenetically	RB
cord-306948-wkisfz1m	309	19	variable	variable	JJ
cord-306948-wkisfz1m	309	20	viruses	virus	NNS
cord-306948-wkisfz1m	310	1	Zhou	Zhou	NNP
cord-306948-wkisfz1m	310	2	et	et	NNP
cord-306948-wkisfz1m	310	3	al	al	NNP
cord-306948-wkisfz1m	310	4	.	.	NNP
cord-306948-wkisfz1m	310	5	,	,	,
cord-306948-wkisfz1m	310	6	2012	2012	CD
cord-306948-wkisfz1m	310	7	)	)	-RRB-
cord-306948-wkisfz1m	310	8	.	.	.
cord-306948-wkisfz1m	311	1	Another	another	DT
cord-306948-wkisfz1m	311	2	approach	approach	NN
cord-306948-wkisfz1m	311	3	to	to	IN
cord-306948-wkisfz1m	311	4	the	the	DT
cord-306948-wkisfz1m	311	5	rapid	rapid	JJ
cord-306948-wkisfz1m	311	6	generation	generation	NN
cord-306948-wkisfz1m	311	7	of	of	IN
cord-306948-wkisfz1m	311	8	attenuated	attenuated	JJ
cord-306948-wkisfz1m	311	9	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	311	10	is	be	VBZ
cord-306948-wkisfz1m	311	11	referred	refer	VBN
cord-306948-wkisfz1m	311	12	to	to	IN
cord-306948-wkisfz1m	311	13	as	as	IN
cord-306948-wkisfz1m	311	14	SAVE	save	VB
cord-306948-wkisfz1m	311	15	(	(	-LRB-
cord-306948-wkisfz1m	311	16	synthetic	synthetic	JJ
cord-306948-wkisfz1m	311	17	attenuated	attenuated	JJ
cord-306948-wkisfz1m	311	18	virus	virus	NN
cord-306948-wkisfz1m	311	19	engineering	engineering	NN
cord-306948-wkisfz1m	311	20	)	)	-RRB-
cord-306948-wkisfz1m	311	21	.	.	.
cord-306948-wkisfz1m	312	1	Codon	codon	NN
cord-306948-wkisfz1m	312	2	-	-	HYPH
cord-306948-wkisfz1m	312	3	pair	pair	NN
cord-306948-wkisfz1m	312	4	bias	bias	NN
cord-306948-wkisfz1m	312	5	is	be	VBZ
cord-306948-wkisfz1m	312	6	a	a	DT
cord-306948-wkisfz1m	312	7	phenomenon	phenomenon	NN
cord-306948-wkisfz1m	312	8	that	that	IN
cord-306948-wkisfz1m	312	9	certain	certain	JJ
cord-306948-wkisfz1m	312	10	codon	codon	NN
cord-306948-wkisfz1m	312	11	pairs	pair	NNS
cord-306948-wkisfz1m	312	12	appear	appear	VBP
cord-306948-wkisfz1m	312	13	in	in	IN
cord-306948-wkisfz1m	312	14	a	a	DT
cord-306948-wkisfz1m	312	15	higher	high	JJR
cord-306948-wkisfz1m	312	16	frequency	frequency	NN
cord-306948-wkisfz1m	312	17	in	in	IN
cord-306948-wkisfz1m	312	18	comparison	comparison	NN
cord-306948-wkisfz1m	312	19	to	to	IN
cord-306948-wkisfz1m	312	20	other	other	JJ
cord-306948-wkisfz1m	312	21	synonymous	synonymous	JJ
cord-306948-wkisfz1m	312	22	codon	codon	NN
cord-306948-wkisfz1m	312	23	pairs	pair	NNS
cord-306948-wkisfz1m	312	24	for	for	IN
cord-306948-wkisfz1m	312	25	the	the	DT
cord-306948-wkisfz1m	312	26	same	same	JJ
cord-306948-wkisfz1m	312	27	amino	amino	NN
cord-306948-wkisfz1m	312	28	acid	acid	NN
cord-306948-wkisfz1m	312	29	,	,	,
cord-306948-wkisfz1m	312	30	and	and	CC
cord-306948-wkisfz1m	312	31	the	the	DT
cord-306948-wkisfz1m	312	32	codon	codon	NN
cord-306948-wkisfz1m	312	33	-	-	HYPH
cord-306948-wkisfz1m	312	34	pair	pair	NN
cord-306948-wkisfz1m	312	35	bias	bias	NN
cord-306948-wkisfz1m	312	36	is	be	VBZ
cord-306948-wkisfz1m	312	37	host	host	NN
cord-306948-wkisfz1m	312	38	species	species	NN
cord-306948-wkisfz1m	312	39	-	-	HYPH
cord-306948-wkisfz1m	312	40	dependent	dependent	JJ
cord-306948-wkisfz1m	312	41	related	relate	VBN
cord-306948-wkisfz1m	312	42	to	to	IN
cord-306948-wkisfz1m	312	43	the	the	DT
cord-306948-wkisfz1m	312	44	efficiency	efficiency	NN
cord-306948-wkisfz1m	312	45	of	of	IN
cord-306948-wkisfz1m	312	46	protein	protein	NN
cord-306948-wkisfz1m	312	47	synthesis	synthesis	NN
cord-306948-wkisfz1m	313	1	(	(	-LRB-
cord-306948-wkisfz1m	313	2	Coleman	Coleman	NNP
cord-306948-wkisfz1m	313	3	et	et	NNP
cord-306948-wkisfz1m	313	4	al	al	NNP
cord-306948-wkisfz1m	313	5	.	.	.
cord-306948-wkisfz1m	314	1	,	,	,
cord-306948-wkisfz1m	314	2	2008	2008	CD
cord-306948-wkisfz1m	314	3	;	;	:
cord-306948-wkisfz1m	314	4	Moura	Moura	NNP
cord-306948-wkisfz1m	314	5	et	et	NNP
cord-306948-wkisfz1m	314	6	al	al	NNP
cord-306948-wkisfz1m	314	7	.	.	NNP
cord-306948-wkisfz1m	314	8	,	,	,
cord-306948-wkisfz1m	314	9	2007	2007	CD
cord-306948-wkisfz1m	314	10	;	;	:
cord-306948-wkisfz1m	314	11	Mueller	Mueller	NNP
cord-306948-wkisfz1m	314	12	et	et	NNP
cord-306948-wkisfz1m	314	13	al	al	NNP
cord-306948-wkisfz1m	314	14	.	.	NNP
cord-306948-wkisfz1m	314	15	,	,	,
cord-306948-wkisfz1m	314	16	2010	2010	CD
cord-306948-wkisfz1m	314	17	)	)	-RRB-
cord-306948-wkisfz1m	314	18	.	.	.
cord-306948-wkisfz1m	315	1	By	by	IN
cord-306948-wkisfz1m	315	2	deoptimizing	deoptimize	VBG
cord-306948-wkisfz1m	315	3	the	the	DT
cord-306948-wkisfz1m	315	4	codon	codon	NN
cord-306948-wkisfz1m	315	5	pair	pair	NN
cord-306948-wkisfz1m	315	6	of	of	IN
cord-306948-wkisfz1m	315	7	a	a	DT
cord-306948-wkisfz1m	315	8	virulence	virulence	NN
cord-306948-wkisfz1m	315	9	gene	gene	NN
cord-306948-wkisfz1m	315	10	,	,	,
cord-306948-wkisfz1m	315	11	an	an	DT
cord-306948-wkisfz1m	315	12	expression	expression	NN
cord-306948-wkisfz1m	315	13	level	level	NN
cord-306948-wkisfz1m	315	14	of	of	IN
cord-306948-wkisfz1m	315	15	this	this	DT
cord-306948-wkisfz1m	315	16	protein	protein	NN
cord-306948-wkisfz1m	315	17	decreases	decrease	VBZ
cord-306948-wkisfz1m	315	18	.	.	.
cord-306948-wkisfz1m	316	1	The	the	DT
cord-306948-wkisfz1m	316	2	computer	computer	NN
cord-306948-wkisfz1m	316	3	-	-	HYPH
cord-306948-wkisfz1m	316	4	aided	aid	VBN
cord-306948-wkisfz1m	316	5	deoptimization	deoptimization	NN
cord-306948-wkisfz1m	316	6	of	of	IN
cord-306948-wkisfz1m	316	7	codon	codon	NN
cord-306948-wkisfz1m	316	8	-	-	HYPH
cord-306948-wkisfz1m	316	9	pairs	pair	NNS
cord-306948-wkisfz1m	316	10	modifies	modify	VBZ
cord-306948-wkisfz1m	316	11	only	only	RB
cord-306948-wkisfz1m	316	12	naturally	naturally	RB
cord-306948-wkisfz1m	316	13	optimized	optimize	VBN
cord-306948-wkisfz1m	316	14	pairs	pair	NNS
cord-306948-wkisfz1m	316	15	of	of	IN
cord-306948-wkisfz1m	316	16	codons	codon	NNS
cord-306948-wkisfz1m	316	17	and	and	CC
cord-306948-wkisfz1m	316	18	does	do	VBZ
cord-306948-wkisfz1m	316	19	not	not	RB
cord-306948-wkisfz1m	316	20	change	change	VB
cord-306948-wkisfz1m	316	21	the	the	DT
cord-306948-wkisfz1m	316	22	amino	amino	NN
cord-306948-wkisfz1m	316	23	acid	acid	NN
cord-306948-wkisfz1m	316	24	sequence	sequence	NN
cord-306948-wkisfz1m	316	25	(	(	-LRB-
cord-306948-wkisfz1m	316	26	Mueller	Mueller	NNP
cord-306948-wkisfz1m	316	27	et	et	NNP
cord-306948-wkisfz1m	316	28	al	al	NNP
cord-306948-wkisfz1m	316	29	.	.	NNP
cord-306948-wkisfz1m	316	30	,	,	,
cord-306948-wkisfz1m	316	31	2010	2010	CD
cord-306948-wkisfz1m	316	32	)	)	-RRB-
cord-306948-wkisfz1m	316	33	.	.	.
cord-306948-wkisfz1m	317	1	Using	use	VBG
cord-306948-wkisfz1m	317	2	this	this	DT
cord-306948-wkisfz1m	317	3	approach	approach	NN
cord-306948-wkisfz1m	317	4	,	,	,
cord-306948-wkisfz1m	317	5	the	the	DT
cord-306948-wkisfz1m	317	6	GP5	GP5	NNP
cord-306948-wkisfz1m	317	7	gene	gene	NN
cord-306948-wkisfz1m	317	8	was	be	VBD
cord-306948-wkisfz1m	317	9	codon	codon	NN
cord-306948-wkisfz1m	317	10	-	-	HYPH
cord-306948-wkisfz1m	317	11	pair	pair	NN
cord-306948-wkisfz1m	317	12	deoptimized	deoptimize	VBN
cord-306948-wkisfz1m	317	13	,	,	,
cord-306948-wkisfz1m	317	14	and	and	CC
cord-306948-wkisfz1m	317	15	a	a	DT
cord-306948-wkisfz1m	317	16	new	new	JJ
cord-306948-wkisfz1m	317	17	virus	virus	NN
cord-306948-wkisfz1m	317	18	was	be	VBD
cord-306948-wkisfz1m	317	19	generated	generate	VBN
cord-306948-wkisfz1m	317	20	.	.	.
cord-306948-wkisfz1m	318	1	The	the	DT
cord-306948-wkisfz1m	318	2	modified	modify	VBN
cord-306948-wkisfz1m	318	3	GP5	gp5	NN
cord-306948-wkisfz1m	318	4	sequence	sequence	NN
cord-306948-wkisfz1m	318	5	did	do	VBD
cord-306948-wkisfz1m	318	6	not	not	RB
cord-306948-wkisfz1m	318	7	affect	affect	VB
cord-306948-wkisfz1m	318	8	the	the	DT
cord-306948-wkisfz1m	318	9	viability	viability	NN
cord-306948-wkisfz1m	318	10	of	of	IN
cord-306948-wkisfz1m	318	11	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	318	12	and	and	CC
cord-306948-wkisfz1m	318	13	the	the	DT
cord-306948-wkisfz1m	318	14	engineered	engineer	VBN
cord-306948-wkisfz1m	318	15	virus	virus	NN
cord-306948-wkisfz1m	318	16	was	be	VBD
cord-306948-wkisfz1m	318	17	clinically	clinically	RB
cord-306948-wkisfz1m	318	18	attenuated	attenuated	JJ
cord-306948-wkisfz1m	318	19	in	in	IN
cord-306948-wkisfz1m	318	20	pigs	pig	NNS
cord-306948-wkisfz1m	318	21	(	(	-LRB-
cord-306948-wkisfz1m	318	22	Ni	Ni	NNP
cord-306948-wkisfz1m	318	23	et	et	NNP
cord-306948-wkisfz1m	318	24	al	al	NNP
cord-306948-wkisfz1m	318	25	.	.	NNP
cord-306948-wkisfz1m	318	26	,	,	,
cord-306948-wkisfz1m	318	27	2014	2014	CD
cord-306948-wkisfz1m	318	28	)	)	-RRB-
cord-306948-wkisfz1m	318	29	.	.	.
cord-306948-wkisfz1m	319	1	To	to	TO
cord-306948-wkisfz1m	319	2	fulfill	fulfill	VB
cord-306948-wkisfz1m	319	3	serological	serological	JJ
cord-306948-wkisfz1m	319	4	discrimination	discrimination	NN
cord-306948-wkisfz1m	319	5	between	between	IN
cord-306948-wkisfz1m	319	6	naturally	naturally	RB
cord-306948-wkisfz1m	319	7	infected	infect	VBN
cord-306948-wkisfz1m	319	8	and	and	CC
cord-306948-wkisfz1m	319	9	vaccinated	vaccinated	JJ
cord-306948-wkisfz1m	319	10	animals	animal	NNS
cord-306948-wkisfz1m	319	11	,	,	,
cord-306948-wkisfz1m	319	12	removing	remove	VBG
cord-306948-wkisfz1m	319	13	an	an	DT
cord-306948-wkisfz1m	319	14	immunodominant	immunodominant	JJ
cord-306948-wkisfz1m	319	15	epitope	epitope	NN
cord-306948-wkisfz1m	319	16	has	have	VBZ
cord-306948-wkisfz1m	319	17	been	be	VBN
cord-306948-wkisfz1m	319	18	applied	apply	VBN
cord-306948-wkisfz1m	319	19	to	to	IN
cord-306948-wkisfz1m	319	20	developing	develop	VBG
cord-306948-wkisfz1m	319	21	a	a	DT
cord-306948-wkisfz1m	319	22	liveattenuated	liveattenuated	JJ
cord-306948-wkisfz1m	319	23	differentiating	differentiate	VBG
cord-306948-wkisfz1m	319	24	infected	infect	VBN
cord-306948-wkisfz1m	319	25	from	from	IN
cord-306948-wkisfz1m	319	26	vaccinated	vaccinated	JJ
cord-306948-wkisfz1m	319	27	animals	animal	NNS
cord-306948-wkisfz1m	319	28	(	(	-LRB-
cord-306948-wkisfz1m	319	29	DIVA	diva	NN
cord-306948-wkisfz1m	319	30	)	)	-RRB-
cord-306948-wkisfz1m	319	31	vaccine	vaccine	NN
cord-306948-wkisfz1m	319	32	against	against	IN
cord-306948-wkisfz1m	319	33	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	319	34	(	(	-LRB-
cord-306948-wkisfz1m	319	35	de	de	NNP
cord-306948-wkisfz1m	319	36	Lima	Lima	NNP
cord-306948-wkisfz1m	319	37	et	et	NNP
cord-306948-wkisfz1m	319	38	al	al	NNP
cord-306948-wkisfz1m	319	39	.	.	NNP
cord-306948-wkisfz1m	319	40	,	,	,
cord-306948-wkisfz1m	319	41	2008	2008	CD
cord-306948-wkisfz1m	319	42	;	;	.
cord-306948-wkisfz1m	320	1	Vu	Vu	NNP
cord-306948-wkisfz1m	320	2	et	et	FW
cord-306948-wkisfz1m	320	3	al	al	NNP
cord-306948-wkisfz1m	320	4	.	.	NNP
cord-306948-wkisfz1m	320	5	,	,	,
cord-306948-wkisfz1m	320	6	2013	2013	CD
cord-306948-wkisfz1m	320	7	)	)	-RRB-
cord-306948-wkisfz1m	320	8	.	.	.
cord-306948-wkisfz1m	321	1	The	the	DT
cord-306948-wkisfz1m	321	2	serologic	serologic	JJ
cord-306948-wkisfz1m	321	3	marker	marker	NN
cord-306948-wkisfz1m	321	4	antigen	antigen	NN
cord-306948-wkisfz1m	321	5	selected	select	VBN
cord-306948-wkisfz1m	321	6	for	for	IN
cord-306948-wkisfz1m	321	7	DIVA	diva	NN
cord-306948-wkisfz1m	321	8	vaccine	vaccine	NN
cord-306948-wkisfz1m	321	9	should	should	MD
cord-306948-wkisfz1m	321	10	be	be	VB
cord-306948-wkisfz1m	321	11	highly	highly	RB
cord-306948-wkisfz1m	321	12	immunodominant	immunodominant	JJ
cord-306948-wkisfz1m	321	13	without	without	IN
cord-306948-wkisfz1m	321	14	disrupting	disrupt	VBG
cord-306948-wkisfz1m	321	15	protective	protective	JJ
cord-306948-wkisfz1m	321	16	well	well	RB
cord-306948-wkisfz1m	321	17	-	-	HYPH
cord-306948-wkisfz1m	321	18	conserved	conserve	VBN
cord-306948-wkisfz1m	321	19	epitopes	epitope	NNS
cord-306948-wkisfz1m	321	20	among	among	IN
cord-306948-wkisfz1m	321	21	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	321	22	isolates	isolate	NNS
cord-306948-wkisfz1m	321	23	and	and	CC
cord-306948-wkisfz1m	321	24	stability	stability	NN
cord-306948-wkisfz1m	321	25	during	during	IN
cord-306948-wkisfz1m	321	26	passages	passage	NNS
cord-306948-wkisfz1m	321	27	.	.	.
cord-306948-wkisfz1m	322	1	Besides	besides	RB
cord-306948-wkisfz1m	322	2	,	,	,
cord-306948-wkisfz1m	322	3	the	the	DT
cord-306948-wkisfz1m	322	4	removal	removal	NN
cord-306948-wkisfz1m	322	5	of	of	IN
cord-306948-wkisfz1m	322	6	a	a	DT
cord-306948-wkisfz1m	322	7	selected	select	VBN
cord-306948-wkisfz1m	322	8	epitope	epitope	NN
cord-306948-wkisfz1m	322	9	should	should	MD
cord-306948-wkisfz1m	322	10	not	not	RB
cord-306948-wkisfz1m	322	11	adversely	adversely	RB
cord-306948-wkisfz1m	322	12	affect	affect	VB
cord-306948-wkisfz1m	322	13	the	the	DT
cord-306948-wkisfz1m	322	14	growth	growth	NN
cord-306948-wkisfz1m	322	15	property	property	NN
cord-306948-wkisfz1m	322	16	or	or	CC
cord-306948-wkisfz1m	322	17	virulence	virulence	NN
cord-306948-wkisfz1m	322	18	of	of	IN
cord-306948-wkisfz1m	322	19	the	the	DT
cord-306948-wkisfz1m	322	20	mutant	mutant	JJ
cord-306948-wkisfz1m	322	21	virus	virus	NN
cord-306948-wkisfz1m	322	22	(	(	-LRB-
cord-306948-wkisfz1m	322	23	de	de	FW
cord-306948-wkisfz1m	322	24	Lima	Lima	NNP
cord-306948-wkisfz1m	322	25	et	et	NNP
cord-306948-wkisfz1m	322	26	al	al	NNP
cord-306948-wkisfz1m	322	27	.	.	NNP
cord-306948-wkisfz1m	322	28	,	,	,
cord-306948-wkisfz1m	322	29	2008	2008	CD
cord-306948-wkisfz1m	322	30	;	;	.
cord-306948-wkisfz1m	323	1	Vu	Vu	NNP
cord-306948-wkisfz1m	323	2	et	et	FW
cord-306948-wkisfz1m	323	3	al	al	NNP
cord-306948-wkisfz1m	323	4	.	.	NNP
cord-306948-wkisfz1m	323	5	,	,	,
cord-306948-wkisfz1m	323	6	2013	2013	CD
cord-306948-wkisfz1m	323	7	)	)	-RRB-
cord-306948-wkisfz1m	323	8	.	.	.
cord-306948-wkisfz1m	324	1	Two	two	CD
cord-306948-wkisfz1m	324	2	epitopes	epitope	NNS
cord-306948-wkisfz1m	324	3	residing	reside	VBG
cord-306948-wkisfz1m	324	4	in	in	IN
cord-306948-wkisfz1m	324	5	nsp2	nsp2	NNP
cord-306948-wkisfz1m	324	6	and	and	CC
cord-306948-wkisfz1m	324	7	M	M	NNP
cord-306948-wkisfz1m	324	8	have	have	VBP
cord-306948-wkisfz1m	324	9	been	be	VBN
cord-306948-wkisfz1m	324	10	identified	identify	VBN
cord-306948-wkisfz1m	324	11	fulfilling	fulfil	VBG
cord-306948-wkisfz1m	324	12	the	the	DT
cord-306948-wkisfz1m	324	13	requirements	requirement	NNS
cord-306948-wkisfz1m	324	14	for	for	IN
cord-306948-wkisfz1m	324	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	324	16	DIVA	DIVA	NNP
cord-306948-wkisfz1m	324	17	vaccine	vaccine	NN
cord-306948-wkisfz1m	324	18	(	(	-LRB-
cord-306948-wkisfz1m	324	19	de	de	FW
cord-306948-wkisfz1m	324	20	Lima	Lima	NNP
cord-306948-wkisfz1m	324	21	et	et	NNP
cord-306948-wkisfz1m	324	22	al	al	NNP
cord-306948-wkisfz1m	324	23	.	.	NNP
cord-306948-wkisfz1m	324	24	,	,	,
cord-306948-wkisfz1m	324	25	2008	2008	CD
cord-306948-wkisfz1m	324	26	;	;	.
cord-306948-wkisfz1m	325	1	Vu	Vu	NNP
cord-306948-wkisfz1m	325	2	et	et	FW
cord-306948-wkisfz1m	325	3	al	al	NNP
cord-306948-wkisfz1m	325	4	.	.	NNP
cord-306948-wkisfz1m	325	5	,	,	,
cord-306948-wkisfz1m	325	6	2013	2013	CD
cord-306948-wkisfz1m	325	7	)	)	-RRB-
cord-306948-wkisfz1m	325	8	.	.	.
cord-306948-wkisfz1m	326	1	Two	two	CD
cord-306948-wkisfz1m	326	2	mutants	mutant	NNS
cord-306948-wkisfz1m	326	3	,	,	,
cord-306948-wkisfz1m	326	4	FLdNsp2/44	FLdNsp2/44	NNP
cord-306948-wkisfz1m	326	5	with	with	IN
cord-306948-wkisfz1m	326	6	a	a	DT
cord-306948-wkisfz1m	326	7	deletion	deletion	NN
cord-306948-wkisfz1m	326	8	of	of	IN
cord-306948-wkisfz1m	326	9	residues	residue	NNS
cord-306948-wkisfz1m	326	10	431	431	CD
cord-306948-wkisfz1m	326	11	-	-	SYM
cord-306948-wkisfz1m	326	12	445	445	CD
cord-306948-wkisfz1m	326	13	within	within	IN
cord-306948-wkisfz1m	326	14	nsp2	nsp2	NNP
cord-306948-wkisfz1m	326	15	,	,	,
cord-306948-wkisfz1m	326	16	and	and	CC
cord-306948-wkisfz1m	326	17	Q164R	Q164R	NNP
cord-306948-wkisfz1m	326	18	disrupting	disrupt	VBG
cord-306948-wkisfz1m	326	19	antigenicity	antigenicity	NN
cord-306948-wkisfz1m	326	20	of	of	IN
cord-306948-wkisfz1m	326	21	epitope	epitope	NN
cord-306948-wkisfz1m	326	22	M201	M201	NNPS
cord-306948-wkisfz1m	326	23	in	in	IN
cord-306948-wkisfz1m	326	24	M	M	NNP
cord-306948-wkisfz1m	326	25	protein	protein	NN
cord-306948-wkisfz1m	326	26	have	have	VBP
cord-306948-wkisfz1m	326	27	been	be	VBN
cord-306948-wkisfz1m	326	28	designed	design	VBN
cord-306948-wkisfz1m	326	29	and	and	CC
cord-306948-wkisfz1m	326	30	constructed	construct	VBN
cord-306948-wkisfz1m	326	31	accordingly	accordingly	RB
cord-306948-wkisfz1m	326	32	(	(	-LRB-
cord-306948-wkisfz1m	326	33	de	de	FW
cord-306948-wkisfz1m	326	34	Lima	Lima	NNP
cord-306948-wkisfz1m	326	35	et	et	NNP
cord-306948-wkisfz1m	326	36	al	al	NNP
cord-306948-wkisfz1m	326	37	.	.	NNP
cord-306948-wkisfz1m	326	38	,	,	,
cord-306948-wkisfz1m	326	39	2008	2008	CD
cord-306948-wkisfz1m	326	40	;	;	.
cord-306948-wkisfz1m	327	1	Vu	Vu	NNP
cord-306948-wkisfz1m	327	2	et	et	FW
cord-306948-wkisfz1m	327	3	al	al	NNP
cord-306948-wkisfz1m	327	4	.	.	NNP
cord-306948-wkisfz1m	327	5	,	,	,
cord-306948-wkisfz1m	327	6	2013	2013	CD
cord-306948-wkisfz1m	327	7	)	)	-RRB-
cord-306948-wkisfz1m	327	8	.	.	.
cord-306948-wkisfz1m	328	1	The	the	DT
cord-306948-wkisfz1m	328	2	immunogenicity	immunogenicity	NN
cord-306948-wkisfz1m	328	3	of	of	IN
cord-306948-wkisfz1m	328	4	those	those	DT
cord-306948-wkisfz1m	328	5	two	two	CD
cord-306948-wkisfz1m	328	6	epitopes	epitope	NNS
cord-306948-wkisfz1m	328	7	has	have	VBZ
cord-306948-wkisfz1m	328	8	been	be	VBN
cord-306948-wkisfz1m	328	9	eliminated	eliminate	VBN
cord-306948-wkisfz1m	328	10	during	during	IN
cord-306948-wkisfz1m	328	11	infection	infection	NN
cord-306948-wkisfz1m	328	12	of	of	IN
cord-306948-wkisfz1m	328	13	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	328	14	mutants	mutant	NNS
cord-306948-wkisfz1m	328	15	,	,	,
cord-306948-wkisfz1m	328	16	and	and	CC
cord-306948-wkisfz1m	328	17	both	both	DT
cord-306948-wkisfz1m	328	18	epitopes	epitope	NNS
cord-306948-wkisfz1m	328	19	may	may	MD
cord-306948-wkisfz1m	328	20	be	be	VB
cord-306948-wkisfz1m	328	21	used	use	VBN
cord-306948-wkisfz1m	328	22	as	as	IN
cord-306948-wkisfz1m	328	23	an	an	DT
cord-306948-wkisfz1m	328	24	immunologic	immunologic	JJ
cord-306948-wkisfz1m	328	25	marker	marker	NN
cord-306948-wkisfz1m	328	26	for	for	IN
cord-306948-wkisfz1m	328	27	DIVA	diva	NN
cord-306948-wkisfz1m	328	28	vaccine	vaccine	NN
cord-306948-wkisfz1m	328	29	development	development	NN
cord-306948-wkisfz1m	328	30	(	(	-LRB-
cord-306948-wkisfz1m	328	31	de	de	NNP
cord-306948-wkisfz1m	328	32	Lima	Lima	NNP
cord-306948-wkisfz1m	328	33	et	et	NNP
cord-306948-wkisfz1m	328	34	al	al	NNP
cord-306948-wkisfz1m	328	35	.	.	NNP
cord-306948-wkisfz1m	328	36	,	,	,
cord-306948-wkisfz1m	328	37	2008	2008	CD
cord-306948-wkisfz1m	328	38	;	;	.
cord-306948-wkisfz1m	329	1	Vu	Vu	NNP
cord-306948-wkisfz1m	329	2	et	et	FW
cord-306948-wkisfz1m	329	3	al	al	NNP
cord-306948-wkisfz1m	329	4	.	.	NNP
cord-306948-wkisfz1m	329	5	,	,	,
cord-306948-wkisfz1m	329	6	2013	2013	CD
cord-306948-wkisfz1m	329	7	)	)	-RRB-
cord-306948-wkisfz1m	329	8	.	.	.
cord-306948-wkisfz1m	330	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	330	2	may	may	MD
cord-306948-wkisfz1m	330	3	serve	serve	VB
cord-306948-wkisfz1m	330	4	as	as	IN
cord-306948-wkisfz1m	330	5	a	a	DT
cord-306948-wkisfz1m	330	6	vaccine	vaccine	NN
cord-306948-wkisfz1m	330	7	vector	vector	NN
cord-306948-wkisfz1m	330	8	.	.	.
cord-306948-wkisfz1m	331	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	331	2	infectious	infectious	JJ
cord-306948-wkisfz1m	331	3	clones	clone	NNS
cord-306948-wkisfz1m	331	4	have	have	VBP
cord-306948-wkisfz1m	331	5	been	be	VBN
cord-306948-wkisfz1m	331	6	developed	develop	VBN
cord-306948-wkisfz1m	331	7	as	as	IN
cord-306948-wkisfz1m	331	8	a	a	DT
cord-306948-wkisfz1m	331	9	gene	gene	NN
cord-306948-wkisfz1m	331	10	delivery	delivery	NN
cord-306948-wkisfz1m	331	11	vector	vector	NN
cord-306948-wkisfz1m	331	12	for	for	IN
cord-306948-wkisfz1m	331	13	foreign	foreign	JJ
cord-306948-wkisfz1m	331	14	gene	gene	NN
cord-306948-wkisfz1m	331	15	expression	expression	NN
cord-306948-wkisfz1m	331	16	.	.	.
cord-306948-wkisfz1m	332	1	Identification	identification	NN
cord-306948-wkisfz1m	332	2	of	of	IN
cord-306948-wkisfz1m	332	3	gene	gene	NN
cord-306948-wkisfz1m	332	4	insertion	insertion	NN
cord-306948-wkisfz1m	332	5	sites	site	NNS
cord-306948-wkisfz1m	332	6	in	in	IN
cord-306948-wkisfz1m	332	7	the	the	DT
cord-306948-wkisfz1m	332	8	viral	viral	JJ
cord-306948-wkisfz1m	332	9	genome	genome	NN
cord-306948-wkisfz1m	332	10	and	and	CC
cord-306948-wkisfz1m	332	11	viral	viral	JJ
cord-306948-wkisfz1m	332	12	infectivity	infectivity	NN
cord-306948-wkisfz1m	332	13	is	be	VBZ
cord-306948-wkisfz1m	332	14	critical	critical	JJ
cord-306948-wkisfz1m	332	15	for	for	IN
cord-306948-wkisfz1m	332	16	gene	gene	NN
cord-306948-wkisfz1m	332	17	delivery	delivery	NN
cord-306948-wkisfz1m	332	18	.	.	.
cord-306948-wkisfz1m	333	1	GFP	GFP	NNP
cord-306948-wkisfz1m	333	2	and	and	CC
cord-306948-wkisfz1m	333	3	B	b	NN
cord-306948-wkisfz1m	333	4	-	-	HYPH
cord-306948-wkisfz1m	333	5	cell	cell	NN
cord-306948-wkisfz1m	333	6	epitopes	epitope	NNS
cord-306948-wkisfz1m	333	7	of	of	IN
cord-306948-wkisfz1m	333	8	the	the	DT
cord-306948-wkisfz1m	333	9	Newcastle	Newcastle	NNP
cord-306948-wkisfz1m	333	10	disease	disease	NN
cord-306948-wkisfz1m	333	11	virus	virus	NN
cord-306948-wkisfz1m	333	12	(	(	-LRB-
cord-306948-wkisfz1m	333	13	NDV	NDV	NNP
cord-306948-wkisfz1m	333	14	)	)	-RRB-
cord-306948-wkisfz1m	334	1	nucleoprotein	nucleoprotein	NNP
cord-306948-wkisfz1m	334	2	have	have	VBP
cord-306948-wkisfz1m	334	3	been	be	VBN
cord-306948-wkisfz1m	334	4	inserted	insert	VBN
cord-306948-wkisfz1m	334	5	into	into	IN
cord-306948-wkisfz1m	334	6	non	non	JJ
cord-306948-wkisfz1m	334	7	-	-	JJ
cord-306948-wkisfz1m	334	8	essential	essential	JJ
cord-306948-wkisfz1m	334	9	regions	region	NNS
cord-306948-wkisfz1m	334	10	of	of	IN
cord-306948-wkisfz1m	334	11	nsp2	nsp2	NN
cord-306948-wkisfz1m	334	12	of	of	IN
cord-306948-wkisfz1m	334	13	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	335	1	(	(	-LRB-
cord-306948-wkisfz1m	335	2	Fang	Fang	NNP
cord-306948-wkisfz1m	335	3	et	et	FW
cord-306948-wkisfz1m	335	4	al	al	NNP
cord-306948-wkisfz1m	335	5	.	.	.
cord-306948-wkisfz1m	336	1	,	,	,
cord-306948-wkisfz1m	336	2	2006b	2006b	CD
cord-306948-wkisfz1m	337	1	(	(	-LRB-
cord-306948-wkisfz1m	337	2	Fang	Fang	NNP
cord-306948-wkisfz1m	337	3	et	et	FW
cord-306948-wkisfz1m	337	4	al	al	NNP
cord-306948-wkisfz1m	337	5	.	.	.
cord-306948-wkisfz1m	338	1	,	,	,
cord-306948-wkisfz1m	338	2	,	,	,
cord-306948-wkisfz1m	338	3	2008	2008	CD
cord-306948-wkisfz1m	338	4	Kim	Kim	NNP
cord-306948-wkisfz1m	338	5	et	et	NNP
cord-306948-wkisfz1m	338	6	al	al	NNP
cord-306948-wkisfz1m	338	7	.	.	NNP
cord-306948-wkisfz1m	338	8	,	,	,
cord-306948-wkisfz1m	338	9	2007	2007	CD
cord-306948-wkisfz1m	339	1	;	;	:
cord-306948-wkisfz1m	339	2	Xu	Xu	NNP
cord-306948-wkisfz1m	339	3	et	et	NNP
cord-306948-wkisfz1m	339	4	al	al	NNP
cord-306948-wkisfz1m	339	5	.	.	NNP
cord-306948-wkisfz1m	339	6	,	,	,
cord-306948-wkisfz1m	339	7	2012a	2012a	CD
cord-306948-wkisfz1m	339	8	)	)	-RRB-
cord-306948-wkisfz1m	339	9	.	.	.
cord-306948-wkisfz1m	340	1	In	in	IN
cord-306948-wkisfz1m	340	2	this	this	DT
cord-306948-wkisfz1m	340	3	approach	approach	NN
cord-306948-wkisfz1m	340	4	however	however	RB
cord-306948-wkisfz1m	340	5	,	,	,
cord-306948-wkisfz1m	340	6	the	the	DT
cord-306948-wkisfz1m	340	7	stability	stability	NN
cord-306948-wkisfz1m	340	8	of	of	IN
cord-306948-wkisfz1m	340	9	the	the	DT
cord-306948-wkisfz1m	340	10	inserted	insert	VBN
cord-306948-wkisfz1m	340	11	gene	gene	NN
cord-306948-wkisfz1m	340	12	was	be	VBD
cord-306948-wkisfz1m	340	13	of	of	IN
cord-306948-wkisfz1m	340	14	a	a	DT
cord-306948-wkisfz1m	340	15	concern	concern	NN
cord-306948-wkisfz1m	340	16	.	.	.
cord-306948-wkisfz1m	341	1	When	when	WRB
cord-306948-wkisfz1m	341	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	341	3	expressing	express	VBG
cord-306948-wkisfz1m	341	4	GFP	GFP	NNP
cord-306948-wkisfz1m	341	5	in	in	IN
cord-306948-wkisfz1m	341	6	nsp2	nsp2	NNP
cord-306948-wkisfz1m	341	7	,	,	,
cord-306948-wkisfz1m	341	8	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	341	9	SD01	SD01	NNP
cord-306948-wkisfz1m	341	10	-	-	HYPH
cord-306948-wkisfz1m	341	11	08-GFP	08-GFP	NNP
cord-306948-wkisfz1m	341	12	,	,	,
cord-306948-wkisfz1m	341	13	was	be	VBD
cord-306948-wkisfz1m	341	14	cell	cell	NN
cord-306948-wkisfz1m	341	15	-	-	HYPH
cord-306948-wkisfz1m	341	16	culture	culture	NN
cord-306948-wkisfz1m	341	17	passaged	passage	VBN
cord-306948-wkisfz1m	341	18	,	,	,
cord-306948-wkisfz1m	341	19	a	a	DT
cord-306948-wkisfz1m	341	20	population	population	NN
cord-306948-wkisfz1m	341	21	of	of	IN
cord-306948-wkisfz1m	341	22	GFP	gfp	NN
cord-306948-wkisfz1m	341	23	-	-	HYPH
cord-306948-wkisfz1m	341	24	expression	expression	NN
cord-306948-wkisfz1m	341	25	negative	negative	JJ
cord-306948-wkisfz1m	341	26	-	-	HYPH
cord-306948-wkisfz1m	341	27	virus	virus	NN
cord-306948-wkisfz1m	341	28	appears	appear	VBZ
cord-306948-wkisfz1m	341	29	by	by	IN
cord-306948-wkisfz1m	341	30	the	the	DT
cord-306948-wkisfz1m	341	31	7th	7th	JJ
cord-306948-wkisfz1m	341	32	passage	passage	NN
cord-306948-wkisfz1m	341	33	.	.	.
cord-306948-wkisfz1m	342	1	Sequencing	sequencing	NN
cord-306948-wkisfz1m	342	2	shows	show	VBZ
cord-306948-wkisfz1m	342	3	a	a	DT
cord-306948-wkisfz1m	342	4	deletion	deletion	NN
cord-306948-wkisfz1m	342	5	of	of	IN
cord-306948-wkisfz1m	342	6	GFP	GFP	NNP
cord-306948-wkisfz1m	342	7	at	at	IN
cord-306948-wkisfz1m	342	8	the	the	DT
cord-306948-wkisfz1m	342	9	N	n	CD
cord-306948-wkisfz1m	342	10	-	-	HYPH
cord-306948-wkisfz1m	342	11	terminal	terminal	JJ
cord-306948-wkisfz1m	342	12	half	half	NN
cord-306948-wkisfz1m	342	13	(	(	-LRB-
cord-306948-wkisfz1m	342	14	1	1	CD
cord-306948-wkisfz1m	342	15	to	to	IN
cord-306948-wkisfz1m	342	16	159	159	CD
cord-306948-wkisfz1m	342	17	)	)	-RRB-
cord-306948-wkisfz1m	342	18	,	,	,
cord-306948-wkisfz1m	342	19	leading	lead	VBG
cord-306948-wkisfz1m	342	20	to	to	IN
cord-306948-wkisfz1m	342	21	the	the	DT
cord-306948-wkisfz1m	342	22	loss	loss	NN
cord-306948-wkisfz1m	342	23	of	of	IN
cord-306948-wkisfz1m	342	24	GFP	GFP	NNP
cord-306948-wkisfz1m	342	25	expression	expression	NN
cord-306948-wkisfz1m	342	26	.	.	.
cord-306948-wkisfz1m	343	1	Insertion	insertion	NN
cord-306948-wkisfz1m	343	2	of	of	IN
cord-306948-wkisfz1m	343	3	2	2	CD
cord-306948-wkisfz1m	343	4	amino	amino	NN
cord-306948-wkisfz1m	343	5	acids	acid	NNS
cord-306948-wkisfz1m	343	6	at	at	IN
cord-306948-wkisfz1m	343	7	position	position	NN
cord-306948-wkisfz1m	343	8	160	160	CD
cord-306948-wkisfz1m	343	9	of	of	IN
cord-306948-wkisfz1m	343	10	GFP	GFP	NNP
cord-306948-wkisfz1m	343	11	was	be	VBD
cord-306948-wkisfz1m	343	12	also	also	RB
cord-306948-wkisfz1m	343	13	observed	observe	VBN
cord-306948-wkisfz1m	343	14	in	in	IN
cord-306948-wkisfz1m	343	15	some	some	DT
cord-306948-wkisfz1m	343	16	viral	viral	JJ
cord-306948-wkisfz1m	343	17	clones	clone	NNS
cord-306948-wkisfz1m	343	18	(	(	-LRB-
cord-306948-wkisfz1m	343	19	Fang	Fang	NNP
cord-306948-wkisfz1m	343	20	et	et	FW
cord-306948-wkisfz1m	343	21	al	al	NNP
cord-306948-wkisfz1m	343	22	.	.	NNP
cord-306948-wkisfz1m	343	23	,	,	,
cord-306948-wkisfz1m	343	24	2006b	2006b	CD
cord-306948-wkisfz1m	343	25	)	)	-RRB-
cord-306948-wkisfz1m	343	26	.	.	.
cord-306948-wkisfz1m	344	1	The	the	DT
cord-306948-wkisfz1m	344	2	stability	stability	NN
cord-306948-wkisfz1m	344	3	of	of	IN
cord-306948-wkisfz1m	344	4	the	the	DT
cord-306948-wkisfz1m	344	5	GFP	GFP	NNP
cord-306948-wkisfz1m	344	6	gene	gene	NN
cord-306948-wkisfz1m	344	7	in	in	IN
cord-306948-wkisfz1m	344	8	this	this	DT
cord-306948-wkisfz1m	344	9	recombinant	recombinant	JJ
cord-306948-wkisfz1m	344	10	virus	virus	NN
cord-306948-wkisfz1m	344	11	was	be	VBD
cord-306948-wkisfz1m	344	12	improved	improve	VBN
cord-306948-wkisfz1m	344	13	by	by	IN
cord-306948-wkisfz1m	344	14	deleting	delete	VBG
cord-306948-wkisfz1m	344	15	the	the	DT
cord-306948-wkisfz1m	344	16	ES4	ES4	NNP
cord-306948-wkisfz1m	344	17	epitope	epitope	NN
cord-306948-wkisfz1m	344	18	located	locate	VBN
cord-306948-wkisfz1m	344	19	downstream	downstream	RB
cord-306948-wkisfz1m	344	20	of	of	IN
cord-306948-wkisfz1m	344	21	the	the	DT
cord-306948-wkisfz1m	344	22	GFP	GFP	NNP
cord-306948-wkisfz1m	344	23	gene	gene	NN
cord-306948-wkisfz1m	344	24	,	,	,
cord-306948-wkisfz1m	344	25	and	and	CC
cord-306948-wkisfz1m	344	26	the	the	DT
cord-306948-wkisfz1m	344	27	GFP	GFP	NNP
cord-306948-wkisfz1m	344	28	expression	expression	NN
cord-306948-wkisfz1m	344	29	in	in	IN
cord-306948-wkisfz1m	344	30	this	this	DT
cord-306948-wkisfz1m	344	31	virus	virus	NN
cord-306948-wkisfz1m	344	32	was	be	VBD
cord-306948-wkisfz1m	344	33	stable	stable	JJ
cord-306948-wkisfz1m	344	34	for	for	IN
cord-306948-wkisfz1m	344	35	10	10	CD
cord-306948-wkisfz1m	344	36	passages	passage	NNS
cord-306948-wkisfz1m	344	37	.	.	.
cord-306948-wkisfz1m	345	1	However	however	RB
cord-306948-wkisfz1m	345	2	,	,	,
cord-306948-wkisfz1m	345	3	R97C	r97c	NN
cord-306948-wkisfz1m	345	4	mutation	mutation	NN
cord-306948-wkisfz1m	345	5	was	be	VBD
cord-306948-wkisfz1m	345	6	found	find	VBN
cord-306948-wkisfz1m	345	7	in	in	IN
cord-306948-wkisfz1m	345	8	GFP	GFP	NNP
cord-306948-wkisfz1m	345	9	,	,	,
cord-306948-wkisfz1m	345	10	and	and	CC
cord-306948-wkisfz1m	345	11	this	this	DT
cord-306948-wkisfz1m	345	12	mutation	mutation	NN
cord-306948-wkisfz1m	345	13	caused	cause	VBD
cord-306948-wkisfz1m	345	14	the	the	DT
cord-306948-wkisfz1m	345	15	loss	loss	NN
cord-306948-wkisfz1m	345	16	of	of	IN
cord-306948-wkisfz1m	345	17	florescence	florescence	NN
cord-306948-wkisfz1m	345	18	(	(	-LRB-
cord-306948-wkisfz1m	345	19	Fang	Fang	NNP
cord-306948-wkisfz1m	345	20	et	et	FW
cord-306948-wkisfz1m	345	21	al	al	NNP
cord-306948-wkisfz1m	345	22	.	.	NNP
cord-306948-wkisfz1m	345	23	,	,	,
cord-306948-wkisfz1m	345	24	2008	2008	CD
cord-306948-wkisfz1m	345	25	)	)	-RRB-
cord-306948-wkisfz1m	345	26	.	.	.
cord-306948-wkisfz1m	346	1	The	the	DT
cord-306948-wkisfz1m	346	2	loss	loss	NN
cord-306948-wkisfz1m	346	3	of	of	IN
cord-306948-wkisfz1m	346	4	fluorescence	fluorescence	NN
cord-306948-wkisfz1m	346	5	was	be	VBD
cord-306948-wkisfz1m	346	6	also	also	RB
cord-306948-wkisfz1m	346	7	observed	observe	VBN
cord-306948-wkisfz1m	346	8	in	in	IN
cord-306948-wkisfz1m	346	9	two	two	CD
cord-306948-wkisfz1m	346	10	other	other	JJ
cord-306948-wkisfz1m	346	11	GFP	GFP	NNP
cord-306948-wkisfz1m	346	12	recombinant	recombinant	JJ
cord-306948-wkisfz1m	346	13	viruses	virus	NNS
cord-306948-wkisfz1m	346	14	during	during	IN
cord-306948-wkisfz1m	346	15	serial	serial	JJ
cord-306948-wkisfz1m	346	16	passages	passage	NNS
cord-306948-wkisfz1m	346	17	.	.	.
cord-306948-wkisfz1m	347	1	In	in	IN
cord-306948-wkisfz1m	347	2	another	another	DT
cord-306948-wkisfz1m	347	3	study	study	NN
cord-306948-wkisfz1m	347	4	,	,	,
cord-306948-wkisfz1m	347	5	the	the	DT
cord-306948-wkisfz1m	347	6	GFP	GFP	NNP
cord-306948-wkisfz1m	347	7	-	-	HYPH
cord-306948-wkisfz1m	347	8	coding	code	VBG
cord-306948-wkisfz1m	347	9	sequence	sequence	NN
cord-306948-wkisfz1m	347	10	remained	remain	VBD
cord-306948-wkisfz1m	347	11	intact	intact	JJ
cord-306948-wkisfz1m	347	12	but	but	CC
cord-306948-wkisfz1m	347	13	point	point	NN
cord-306948-wkisfz1m	347	14	mutations	mutation	NNS
cord-306948-wkisfz1m	347	15	were	be	VBD
cord-306948-wkisfz1m	347	16	identified	identify	VBN
cord-306948-wkisfz1m	347	17	and	and	CC
cord-306948-wkisfz1m	347	18	these	these	DT
cord-306948-wkisfz1m	347	19	mutations	mutation	NNS
cord-306948-wkisfz1m	347	20	caused	cause	VBD
cord-306948-wkisfz1m	347	21	amino	amino	NN
cord-306948-wkisfz1m	347	22	acid	acid	NN
cord-306948-wkisfz1m	347	23	changes	change	NNS
cord-306948-wkisfz1m	347	24	to	to	IN
cord-306948-wkisfz1m	347	25	R96C	r96c	NN
cord-306948-wkisfz1m	347	26	and	and	CC
cord-306948-wkisfz1m	347	27	N106Y	N106Y	NNP
cord-306948-wkisfz1m	347	28	(	(	-LRB-
cord-306948-wkisfz1m	347	29	Kim	Kim	NNP
cord-306948-wkisfz1m	347	30	et	et	NNP
cord-306948-wkisfz1m	347	31	al	al	NNP
cord-306948-wkisfz1m	347	32	.	.	NNP
cord-306948-wkisfz1m	347	33	,	,	,
cord-306948-wkisfz1m	347	34	2007	2007	CD
cord-306948-wkisfz1m	347	35	)	)	-RRB-
cord-306948-wkisfz1m	347	36	.	.	.
cord-306948-wkisfz1m	348	1	The	the	DT
cord-306948-wkisfz1m	348	2	expression	expression	NN
cord-306948-wkisfz1m	348	3	of	of	IN
cord-306948-wkisfz1m	348	4	49	49	CD
cord-306948-wkisfz1m	348	5	aa	aa	NNP
cord-306948-wkisfz1m	348	6	B	B	NNP
cord-306948-wkisfz1m	348	7	-	-	HYPH
cord-306948-wkisfz1m	348	8	cell	cell	NN
cord-306948-wkisfz1m	348	9	epitope	epitope	NN
cord-306948-wkisfz1m	348	10	of	of	IN
cord-306948-wkisfz1m	348	11	the	the	DT
cord-306948-wkisfz1m	348	12	NDV	ndv	JJ
cord-306948-wkisfz1m	348	13	nucleoprotein	nucleoprotein	NN
cord-306948-wkisfz1m	348	14	in	in	IN
cord-306948-wkisfz1m	348	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	348	16	nsp2	nsp2	NNP
cord-306948-wkisfz1m	348	17	remained	remain	VBD
cord-306948-wkisfz1m	348	18	stable	stable	JJ
cord-306948-wkisfz1m	348	19	in	in	IN
cord-306948-wkisfz1m	348	20	cell	cell	NN
cord-306948-wkisfz1m	348	21	culture	culture	NN
cord-306948-wkisfz1m	348	22	up	up	IN
cord-306948-wkisfz1m	348	23	to	to	TO
cord-306948-wkisfz1m	348	24	20	20	CD
cord-306948-wkisfz1m	348	25	passages	passage	NNS
cord-306948-wkisfz1m	348	26	(	(	-LRB-
cord-306948-wkisfz1m	348	27	Xu	Xu	NNP
cord-306948-wkisfz1m	348	28	et	et	NNP
cord-306948-wkisfz1m	348	29	al	al	NNP
cord-306948-wkisfz1m	348	30	.	.	NNP
cord-306948-wkisfz1m	348	31	,	,	,
cord-306948-wkisfz1m	348	32	2012a	2012a	CD
cord-306948-wkisfz1m	348	33	;	;	:
cord-306948-wkisfz1m	348	34	Zhang	Zhang	NNP
cord-306948-wkisfz1m	348	35	et	et	NNP
cord-306948-wkisfz1m	348	36	al	al	NNP
cord-306948-wkisfz1m	348	37	.	.	NNP
cord-306948-wkisfz1m	348	38	,	,	,
cord-306948-wkisfz1m	348	39	2011	2011	CD
cord-306948-wkisfz1m	348	40	)	)	-RRB-
cord-306948-wkisfz1m	348	41	.	.	.
cord-306948-wkisfz1m	349	1	The	the	DT
cord-306948-wkisfz1m	349	2	instability	instability	NN
cord-306948-wkisfz1m	349	3	of	of	IN
cord-306948-wkisfz1m	349	4	foreign	foreign	JJ
cord-306948-wkisfz1m	349	5	gene	gene	NN
cord-306948-wkisfz1m	349	6	insertion	insertion	NN
cord-306948-wkisfz1m	349	7	in	in	IN
cord-306948-wkisfz1m	349	8	nsp2	nsp2	NNP
cord-306948-wkisfz1m	349	9	is	be	VBZ
cord-306948-wkisfz1m	349	10	not	not	RB
cord-306948-wkisfz1m	349	11	fully	fully	RB
cord-306948-wkisfz1m	349	12	understood	understand	VBN
cord-306948-wkisfz1m	349	13	.	.	.
cord-306948-wkisfz1m	350	1	The	the	DT
cord-306948-wkisfz1m	350	2	length	length	NN
cord-306948-wkisfz1m	350	3	of	of	IN
cord-306948-wkisfz1m	350	4	insertion	insertion	NN
cord-306948-wkisfz1m	350	5	may	may	MD
cord-306948-wkisfz1m	350	6	be	be	VB
cord-306948-wkisfz1m	350	7	important	important	JJ
cord-306948-wkisfz1m	350	8	for	for	IN
cord-306948-wkisfz1m	350	9	stability	stability	NN
cord-306948-wkisfz1m	350	10	.	.	.
cord-306948-wkisfz1m	351	1	An	an	DT
cord-306948-wkisfz1m	351	2	attempt	attempt	NN
cord-306948-wkisfz1m	351	3	was	be	VBD
cord-306948-wkisfz1m	351	4	made	make	VBN
cord-306948-wkisfz1m	351	5	to	to	TO
cord-306948-wkisfz1m	351	6	produce	produce	VB
cord-306948-wkisfz1m	351	7	an	an	DT
cord-306948-wkisfz1m	351	8	additional	additional	JJ
cord-306948-wkisfz1m	351	9	mRNA	mrna	NN
cord-306948-wkisfz1m	351	10	for	for	IN
cord-306948-wkisfz1m	351	11	foreign	foreign	JJ
cord-306948-wkisfz1m	351	12	gene	gene	NN
cord-306948-wkisfz1m	351	13	expression	expression	NN
cord-306948-wkisfz1m	351	14	.	.	.
cord-306948-wkisfz1m	352	1	The	the	DT
cord-306948-wkisfz1m	352	2	GFP	GFP	NNP
cord-306948-wkisfz1m	352	3	gene	gene	NN
cord-306948-wkisfz1m	352	4	was	be	VBD
cord-306948-wkisfz1m	352	5	inserted	insert	VBN
cord-306948-wkisfz1m	352	6	between	between	IN
cord-306948-wkisfz1m	352	7	ORF1b	ORF1b	NNP
cord-306948-wkisfz1m	352	8	and	and	CC
cord-306948-wkisfz1m	352	9	ORF2a	ORF2a	NNP
cord-306948-wkisfz1m	352	10	for	for	IN
cord-306948-wkisfz1m	352	11	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	352	12	along	along	IN
cord-306948-wkisfz1m	352	13	with	with	IN
cord-306948-wkisfz1m	352	14	a	a	DT
cord-306948-wkisfz1m	352	15	copy	copy	NN
cord-306948-wkisfz1m	352	16	of	of	IN
cord-306948-wkisfz1m	352	17	TRS	TRS	NNP
cord-306948-wkisfz1m	352	18	Pei	Pei	NNP
cord-306948-wkisfz1m	352	19	et	et	NNP
cord-306948-wkisfz1m	352	20	al	al	NNP
cord-306948-wkisfz1m	352	21	.	.	NNP
cord-306948-wkisfz1m	352	22	,	,	,
cord-306948-wkisfz1m	352	23	2009	2009	CD
cord-306948-wkisfz1m	352	24	;	;	:
cord-306948-wkisfz1m	352	25	Sang	Sang	NNP
cord-306948-wkisfz1m	352	26	et	et	FW
cord-306948-wkisfz1m	352	27	al	al	NNP
cord-306948-wkisfz1m	352	28	.	.	NNP
cord-306948-wkisfz1m	352	29	,	,	,
cord-306948-wkisfz1m	352	30	2012	2012	CD
cord-306948-wkisfz1m	352	31	;	;	:
cord-306948-wkisfz1m	352	32	Yoo	Yoo	NNP
cord-306948-wkisfz1m	352	33	et	et	NNP
cord-306948-wkisfz1m	352	34	al	al	NNP
cord-306948-wkisfz1m	352	35	.	.	NNP
cord-306948-wkisfz1m	352	36	,	,	,
cord-306948-wkisfz1m	352	37	2004	2004	CD
cord-306948-wkisfz1m	352	38	)	)	-RRB-
cord-306948-wkisfz1m	352	39	.	.	.
cord-306948-wkisfz1m	353	1	Compared	compare	VBN
cord-306948-wkisfz1m	353	2	to	to	IN
cord-306948-wkisfz1m	353	3	insertion	insertion	NN
cord-306948-wkisfz1m	353	4	in	in	IN
cord-306948-wkisfz1m	353	5	nsp2	nsp2	NNP
cord-306948-wkisfz1m	353	6	,	,	,
cord-306948-wkisfz1m	353	7	this	this	DT
cord-306948-wkisfz1m	353	8	site	site	NN
cord-306948-wkisfz1m	353	9	is	be	VBZ
cord-306948-wkisfz1m	353	10	suitable	suitable	JJ
cord-306948-wkisfz1m	353	11	for	for	IN
cord-306948-wkisfz1m	353	12	foreign	foreign	JJ
cord-306948-wkisfz1m	353	13	gene	gene	NN
cord-306948-wkisfz1m	353	14	insertion	insertion	NN
cord-306948-wkisfz1m	353	15	since	since	IN
cord-306948-wkisfz1m	353	16	the	the	DT
cord-306948-wkisfz1m	353	17	recombinant	recombinant	JJ
cord-306948-wkisfz1m	353	18	virus	virus	NN
cord-306948-wkisfz1m	353	19	was	be	VBD
cord-306948-wkisfz1m	353	20	stable	stable	JJ
cord-306948-wkisfz1m	353	21	for	for	IN
cord-306948-wkisfz1m	353	22	up	up	IN
cord-306948-wkisfz1m	353	23	to	to	TO
cord-306948-wkisfz1m	353	24	at	at	RB
cord-306948-wkisfz1m	353	25	least	least	RBS
cord-306948-wkisfz1m	353	26	37	37	CD
cord-306948-wkisfz1m	353	27	passages	passage	NNS
cord-306948-wkisfz1m	353	28	without	without	IN
cord-306948-wkisfz1m	353	29	the	the	DT
cord-306948-wkisfz1m	353	30	loss	loss	NN
cord-306948-wkisfz1m	353	31	of	of	IN
cord-306948-wkisfz1m	353	32	gene	gene	NN
cord-306948-wkisfz1m	353	33	or	or	CC
cord-306948-wkisfz1m	353	34	fluorescence	fluorescence	NN
cord-306948-wkisfz1m	353	35	(	(	-LRB-
cord-306948-wkisfz1m	353	36	Pei	Pei	NNP
cord-306948-wkisfz1m	353	37	et	et	NNP
cord-306948-wkisfz1m	353	38	al	al	NNP
cord-306948-wkisfz1m	353	39	.	.	NNP
cord-306948-wkisfz1m	353	40	,	,	,
cord-306948-wkisfz1m	353	41	2009	2009	CD
cord-306948-wkisfz1m	353	42	)	)	-RRB-
cord-306948-wkisfz1m	353	43	.	.	.
cord-306948-wkisfz1m	354	1	The	the	DT
cord-306948-wkisfz1m	354	2	genetic	genetic	JJ
cord-306948-wkisfz1m	354	3	stability	stability	NN
cord-306948-wkisfz1m	354	4	of	of	IN
cord-306948-wkisfz1m	354	5	genes	gene	NNS
cord-306948-wkisfz1m	354	6	inserted	insert	VBN
cord-306948-wkisfz1m	354	7	at	at	IN
cord-306948-wkisfz1m	354	8	this	this	DT
cord-306948-wkisfz1m	354	9	site	site	NN
cord-306948-wkisfz1m	354	10	has	have	VBZ
cord-306948-wkisfz1m	354	11	been	be	VBN
cord-306948-wkisfz1m	354	12	confirmed	confirm	VBN
cord-306948-wkisfz1m	354	13	by	by	IN
cord-306948-wkisfz1m	354	14	expressing	express	VBG
cord-306948-wkisfz1m	354	15	other	other	JJ
cord-306948-wkisfz1m	354	16	genes	gene	NNS
cord-306948-wkisfz1m	354	17	including	include	VBG
cord-306948-wkisfz1m	354	18	DsRed	DsRed	NNP
cord-306948-wkisfz1m	354	19	,	,	,
cord-306948-wkisfz1m	354	20	Renilla	Renilla	NNP
cord-306948-wkisfz1m	354	21	luciferease	luciferease	NNP
cord-306948-wkisfz1m	354	22	,	,	,
cord-306948-wkisfz1m	354	23	IFNa1	IFNa1	NNP
cord-306948-wkisfz1m	354	24	,	,	,
cord-306948-wkisfz1m	354	25	IFNb	IFNb	NNS
cord-306948-wkisfz1m	354	26	,	,	,
cord-306948-wkisfz1m	354	27	IFNd3	ifnd3	NN
cord-306948-wkisfz1m	354	28	,	,	,
cord-306948-wkisfz1m	354	29	and	and	CC
cord-306948-wkisfz1m	354	30	IFNv5	ifnv5	FW
cord-306948-wkisfz1m	354	31	(	(	-LRB-
cord-306948-wkisfz1m	354	32	Sang	Sang	NNP
cord-306948-wkisfz1m	354	33	et	et	FW
cord-306948-wkisfz1m	354	34	al	al	NNP
cord-306948-wkisfz1m	354	35	.	.	NNP
cord-306948-wkisfz1m	354	36	,	,	,
cord-306948-wkisfz1m	354	37	2012	2012	CD
cord-306948-wkisfz1m	354	38	)	)	-RRB-
cord-306948-wkisfz1m	354	39	.	.	.
cord-306948-wkisfz1m	355	1	This	this	DT
cord-306948-wkisfz1m	355	2	approach	approach	NN
cord-306948-wkisfz1m	355	3	has	have	VBZ
cord-306948-wkisfz1m	355	4	the	the	DT
cord-306948-wkisfz1m	355	5	particular	particular	JJ
cord-306948-wkisfz1m	355	6	advantage	advantage	NN
cord-306948-wkisfz1m	355	7	of	of	IN
cord-306948-wkisfz1m	355	8	eliminating	eliminate	VBG
cord-306948-wkisfz1m	355	9	the	the	DT
cord-306948-wkisfz1m	355	10	need	need	NN
cord-306948-wkisfz1m	355	11	to	to	TO
cord-306948-wkisfz1m	355	12	alter	alter	VB
cord-306948-wkisfz1m	355	13	the	the	DT
cord-306948-wkisfz1m	355	14	coding	code	VBG
cord-306948-wkisfz1m	355	15	sequence	sequence	NN
cord-306948-wkisfz1m	355	16	of	of	IN
cord-306948-wkisfz1m	355	17	a	a	DT
cord-306948-wkisfz1m	355	18	viral	viral	JJ
cord-306948-wkisfz1m	355	19	gene	gene	NN
cord-306948-wkisfz1m	355	20	and	and	CC
cord-306948-wkisfz1m	355	21	also	also	RB
cord-306948-wkisfz1m	355	22	of	of	IN
cord-306948-wkisfz1m	355	23	minimizing	minimize	VBG
cord-306948-wkisfz1m	355	24	the	the	DT
cord-306948-wkisfz1m	355	25	effects	effect	NNS
cord-306948-wkisfz1m	355	26	on	on	IN
cord-306948-wkisfz1m	355	27	expression	expression	NN
cord-306948-wkisfz1m	355	28	and	and	CC
cord-306948-wkisfz1m	355	29	post	post	JJ
cord-306948-wkisfz1m	355	30	-	-	JJ
cord-306948-wkisfz1m	355	31	translational	translational	JJ
cord-306948-wkisfz1m	355	32	modification	modification	NN
cord-306948-wkisfz1m	355	33	of	of	IN
cord-306948-wkisfz1m	355	34	viral	viral	JJ
cord-306948-wkisfz1m	355	35	proteins	protein	NNS
cord-306948-wkisfz1m	355	36	(	(	-LRB-
cord-306948-wkisfz1m	355	37	Pei	Pei	NNP
cord-306948-wkisfz1m	355	38	et	et	NNP
cord-306948-wkisfz1m	355	39	al	al	NNP
cord-306948-wkisfz1m	355	40	.	.	NNP
cord-306948-wkisfz1m	355	41	,	,	,
cord-306948-wkisfz1m	355	42	2009	2009	CD
cord-306948-wkisfz1m	355	43	)	)	-RRB-
cord-306948-wkisfz1m	355	44	.	.	.
cord-306948-wkisfz1m	356	1	Infectious	infectious	JJ
cord-306948-wkisfz1m	356	2	clones	clone	NNS
cord-306948-wkisfz1m	356	3	are	be	VBP
cord-306948-wkisfz1m	356	4	important	important	JJ
cord-306948-wkisfz1m	356	5	molecular	molecular	JJ
cord-306948-wkisfz1m	356	6	tools	tool	NNS
cord-306948-wkisfz1m	356	7	to	to	TO
cord-306948-wkisfz1m	356	8	study	study	VB
cord-306948-wkisfz1m	356	9	structure	structure	NN
cord-306948-wkisfz1m	356	10	function	function	NN
cord-306948-wkisfz1m	356	11	relationships	relationship	NNS
cord-306948-wkisfz1m	356	12	of	of	IN
cord-306948-wkisfz1m	356	13	proteins	protein	NNS
cord-306948-wkisfz1m	356	14	and	and	CC
cord-306948-wkisfz1m	356	15	genomic	genomic	JJ
cord-306948-wkisfz1m	356	16	sequences	sequence	NNS
cord-306948-wkisfz1m	356	17	at	at	IN
cord-306948-wkisfz1m	356	18	the	the	DT
cord-306948-wkisfz1m	356	19	infectious	infectious	JJ
cord-306948-wkisfz1m	356	20	virus	virus	NN
cord-306948-wkisfz1m	356	21	level	level	NN
cord-306948-wkisfz1m	356	22	in	in	IN
cord-306948-wkisfz1m	356	23	vivo	vivo	NN
cord-306948-wkisfz1m	356	24	.	.	.
cord-306948-wkisfz1m	357	1	Specific	specific	JJ
cord-306948-wkisfz1m	357	2	sequence	sequence	NN
cord-306948-wkisfz1m	357	3	motifs	motif	NNS
cord-306948-wkisfz1m	357	4	may	may	MD
cord-306948-wkisfz1m	357	5	be	be	VB
cord-306948-wkisfz1m	357	6	mutated	mutate	VBN
cord-306948-wkisfz1m	357	7	or	or	CC
cord-306948-wkisfz1m	357	8	deleted	delete	VBN
cord-306948-wkisfz1m	357	9	from	from	IN
cord-306948-wkisfz1m	357	10	the	the	DT
cord-306948-wkisfz1m	357	11	virus	virus	NN
cord-306948-wkisfz1m	357	12	and	and	CC
cord-306948-wkisfz1m	357	13	their	-PRON-	PRP$
cord-306948-wkisfz1m	357	14	phenotypes	phenotype	NNS
cord-306948-wkisfz1m	357	15	may	may	MD
cord-306948-wkisfz1m	357	16	be	be	VB
cord-306948-wkisfz1m	357	17	examined	examine	VBN
cord-306948-wkisfz1m	357	18	to	to	TO
cord-306948-wkisfz1m	357	19	determine	determine	VB
cord-306948-wkisfz1m	357	20	their	-PRON-	PRP$
cord-306948-wkisfz1m	357	21	functions	function	NNS
cord-306948-wkisfz1m	357	22	.	.	.
cord-306948-wkisfz1m	358	1	The	the	DT
cord-306948-wkisfz1m	358	2	removal	removal	NN
cord-306948-wkisfz1m	358	3	of	of	IN
cord-306948-wkisfz1m	358	4	N	n	NN
cord-306948-wkisfz1m	358	5	-	-	HYPH
cord-306948-wkisfz1m	358	6	linked	link	VBN
cord-306948-wkisfz1m	358	7	glycosylation	glycosylation	NN
cord-306948-wkisfz1m	358	8	at	at	IN
cord-306948-wkisfz1m	358	9	N34	N34	NNP
cord-306948-wkisfz1m	358	10	and	and	CC
cord-306948-wkisfz1m	358	11	N51	N51	NNP
cord-306948-wkisfz1m	358	12	of	of	IN
cord-306948-wkisfz1m	358	13	GP5	GP5	NNP
cord-306948-wkisfz1m	358	14	results	result	NNS
cord-306948-wkisfz1m	358	15	in	in	IN
cord-306948-wkisfz1m	358	16	a	a	DT
cord-306948-wkisfz1m	358	17	mutant	mutant	JJ
cord-306948-wkisfz1m	358	18	virus	virus	NN
cord-306948-wkisfz1m	358	19	with	with	IN
cord-306948-wkisfz1m	358	20	its	-PRON-	PRP$
cord-306948-wkisfz1m	358	21	phenotype	phenotype	NN
cord-306948-wkisfz1m	358	22	of	of	IN
cord-306948-wkisfz1m	358	23	enhanced	enhanced	JJ
cord-306948-wkisfz1m	358	24	sensitivity	sensitivity	NN
cord-306948-wkisfz1m	358	25	to	to	IN
cord-306948-wkisfz1m	358	26	serum	serum	NN
cord-306948-wkisfz1m	358	27	neutralization	neutralization	NN
cord-306948-wkisfz1m	358	28	and	and	CC
cord-306948-wkisfz1m	358	29	high	high	JJ
cord-306948-wkisfz1m	358	30	level	level	NN
cord-306948-wkisfz1m	358	31	induction	induction	NN
cord-306948-wkisfz1m	358	32	of	of	IN
cord-306948-wkisfz1m	358	33	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	358	34	antibodies	antibody	NNS
cord-306948-wkisfz1m	358	35	.	.	.
cord-306948-wkisfz1m	359	1	Elimination	elimination	NN
cord-306948-wkisfz1m	359	2	of	of	IN
cord-306948-wkisfz1m	359	3	N44-linked	N44-linked	NNP
cord-306948-wkisfz1m	359	4	glycan	glycan	NN
cord-306948-wkisfz1m	359	5	is	be	VBZ
cord-306948-wkisfz1m	359	6	not	not	RB
cord-306948-wkisfz1m	359	7	in	in	IN
cord-306948-wkisfz1m	359	8	concert	concert	NN
cord-306948-wkisfz1m	359	9	with	with	IN
cord-306948-wkisfz1m	359	10	a	a	DT
cord-306948-wkisfz1m	359	11	high	high	JJ
cord-306948-wkisfz1m	359	12	-	-	HYPH
cord-306948-wkisfz1m	359	13	level	level	NN
cord-306948-wkisfz1m	359	14	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	359	15	antibody	antibody	NN
cord-306948-wkisfz1m	359	16	response	response	NN
cord-306948-wkisfz1m	359	17	to	to	IN
cord-306948-wkisfz1m	359	18	wild	wild	JJ
cord-306948-wkisfz1m	359	19	type	type	NN
cord-306948-wkisfz1m	359	20	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	359	21	.	.	.
cord-306948-wkisfz1m	360	1	Meanwhile	meanwhile	RB
cord-306948-wkisfz1m	360	2	,	,	,
cord-306948-wkisfz1m	360	3	introduction	introduction	NN
cord-306948-wkisfz1m	360	4	of	of	IN
cord-306948-wkisfz1m	360	5	multiple	multiple	JJ
cord-306948-wkisfz1m	360	6	mutations	mutation	NNS
cord-306948-wkisfz1m	360	7	at	at	IN
cord-306948-wkisfz1m	360	8	these	these	DT
cord-306948-wkisfz1m	360	9	N	n	NN
cord-306948-wkisfz1m	360	10	-	-	HYPH
cord-306948-wkisfz1m	360	11	linked	link	VBN
cord-306948-wkisfz1m	360	12	glycosylation	glycosylation	NN
cord-306948-wkisfz1m	360	13	sites	site	NNS
cord-306948-wkisfz1m	360	14	could	could	MD
cord-306948-wkisfz1m	360	15	significantly	significantly	RB
cord-306948-wkisfz1m	360	16	reduce	reduce	VB
cord-306948-wkisfz1m	360	17	virus	virus	NN
cord-306948-wkisfz1m	360	18	yields	yield	NNS
cord-306948-wkisfz1m	360	19	.	.	.
cord-306948-wkisfz1m	361	1	The	the	DT
cord-306948-wkisfz1m	361	2	E	e	NN
cord-306948-wkisfz1m	361	3	gene	gene	NN
cord-306948-wkisfz1m	361	4	knock	knock	VB
cord-306948-wkisfz1m	361	5	-	-	HYPH
cord-306948-wkisfz1m	361	6	out	out	RP
cord-306948-wkisfz1m	361	7	mutation	mutation	NN
cord-306948-wkisfz1m	361	8	allows	allow	VBZ
cord-306948-wkisfz1m	361	9	for	for	IN
cord-306948-wkisfz1m	361	10	genome	genome	NN
cord-306948-wkisfz1m	361	11	replication	replication	NN
cord-306948-wkisfz1m	361	12	and	and	CC
cord-306948-wkisfz1m	361	13	transcription	transcription	NN
cord-306948-wkisfz1m	361	14	but	but	CC
cord-306948-wkisfz1m	361	15	does	do	VBZ
cord-306948-wkisfz1m	361	16	not	not	RB
cord-306948-wkisfz1m	361	17	produce	produce	VB
cord-306948-wkisfz1m	361	18	infectious	infectious	JJ
cord-306948-wkisfz1m	361	19	progeny	progeny	NN
cord-306948-wkisfz1m	361	20	,	,	,
cord-306948-wkisfz1m	361	21	indicating	indicate	VBG
cord-306948-wkisfz1m	361	22	that	that	IN
cord-306948-wkisfz1m	361	23	the	the	DT
cord-306948-wkisfz1m	361	24	E	e	NN
cord-306948-wkisfz1m	361	25	protein	protein	NN
cord-306948-wkisfz1m	361	26	is	be	VBZ
cord-306948-wkisfz1m	361	27	essential	essential	JJ
cord-306948-wkisfz1m	361	28	for	for	IN
cord-306948-wkisfz1m	361	29	virion	virion	NN
cord-306948-wkisfz1m	361	30	assembly	assembly	NN
cord-306948-wkisfz1m	361	31	.	.	.
cord-306948-wkisfz1m	362	1	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	363	1	nsp1	nsp1	NN
cord-306948-wkisfz1m	363	2	is	be	VBZ
cord-306948-wkisfz1m	363	3	a	a	DT
cord-306948-wkisfz1m	363	4	multifunctional	multifunctional	JJ
cord-306948-wkisfz1m	363	5	protein	protein	NN
cord-306948-wkisfz1m	363	6	regulating	regulate	VBG
cord-306948-wkisfz1m	363	7	the	the	DT
cord-306948-wkisfz1m	363	8	accumulation	accumulation	NN
cord-306948-wkisfz1m	363	9	of	of	IN
cord-306948-wkisfz1m	363	10	genomic	genomic	JJ
cord-306948-wkisfz1m	363	11	RNA	RNA	NNP
cord-306948-wkisfz1m	363	12	and	and	CC
cord-306948-wkisfz1m	363	13	mRNAs	mRNAs	NNPS
cord-306948-wkisfz1m	363	14	.	.	.
cord-306948-wkisfz1m	364	1	It	-PRON-	PRP
cord-306948-wkisfz1m	364	2	also	also	RB
cord-306948-wkisfz1m	364	3	has	have	VBZ
cord-306948-wkisfz1m	364	4	the	the	DT
cord-306948-wkisfz1m	364	5	ability	ability	NN
cord-306948-wkisfz1m	364	6	to	to	TO
cord-306948-wkisfz1m	364	7	modulate	modulate	VB
cord-306948-wkisfz1m	364	8	the	the	DT
cord-306948-wkisfz1m	364	9	host	host	NN
cord-306948-wkisfz1m	364	10	innate	innate	JJ
cord-306948-wkisfz1m	364	11	immunity	immunity	NN
cord-306948-wkisfz1m	364	12	by	by	IN
cord-306948-wkisfz1m	364	13	suppressing	suppress	VBG
cord-306948-wkisfz1m	364	14	the	the	DT
cord-306948-wkisfz1m	364	15	type	type	NN
cord-306948-wkisfz1m	364	16	I	-PRON-	PRP
cord-306948-wkisfz1m	364	17	IFN	IFN	NNP
cord-306948-wkisfz1m	364	18	production	production	NN
cord-306948-wkisfz1m	365	1	(	(	-LRB-
cord-306948-wkisfz1m	365	2	Nedialkova	Nedialkova	NNP
cord-306948-wkisfz1m	365	3	et	et	NNP
cord-306948-wkisfz1m	365	4	al	al	NNP
cord-306948-wkisfz1m	365	5	.	.	NNP
cord-306948-wkisfz1m	365	6	,	,	,
cord-306948-wkisfz1m	365	7	2010	2010	CD
cord-306948-wkisfz1m	365	8	;	;	:
cord-306948-wkisfz1m	365	9	Sun	Sun	NNP
cord-306948-wkisfz1m	365	10	et	et	NNP
cord-306948-wkisfz1m	365	11	al	al	NNP
cord-306948-wkisfz1m	365	12	.	.	NNP
cord-306948-wkisfz1m	365	13	,	,	,
cord-306948-wkisfz1m	365	14	2012a	2012a	CD
cord-306948-wkisfz1m	365	15	;	;	:
cord-306948-wkisfz1m	365	16	Yoo	Yoo	NNP
cord-306948-wkisfz1m	365	17	et	et	NNP
cord-306948-wkisfz1m	365	18	al	al	NNP
cord-306948-wkisfz1m	365	19	.	.	NNP
cord-306948-wkisfz1m	365	20	,	,	,
cord-306948-wkisfz1m	365	21	2010	2010	CD
cord-306948-wkisfz1m	365	22	)	)	-RRB-
cord-306948-wkisfz1m	365	23	.	.	.
cord-306948-wkisfz1m	366	1	The	the	DT
cord-306948-wkisfz1m	366	2	motifs	motif	NNS
cord-306948-wkisfz1m	366	3	for	for	IN
cord-306948-wkisfz1m	366	4	zinc	zinc	NN
cord-306948-wkisfz1m	366	5	fingers	finger	NNS
cord-306948-wkisfz1m	366	6	,	,	,
cord-306948-wkisfz1m	366	7	PLPs	plp	NNS
cord-306948-wkisfz1m	366	8	,	,	,
cord-306948-wkisfz1m	366	9	and	and	CC
cord-306948-wkisfz1m	366	10	nuclease	nuclease	NN
cord-306948-wkisfz1m	366	11	have	have	VBP
cord-306948-wkisfz1m	366	12	been	be	VBN
cord-306948-wkisfz1m	366	13	identified	identify	VBN
cord-306948-wkisfz1m	366	14	in	in	IN
cord-306948-wkisfz1m	366	15	nsp1	nsp1	NNS
cord-306948-wkisfz1m	366	16	(	(	-LRB-
cord-306948-wkisfz1m	366	17	Fang	Fang	NNP
cord-306948-wkisfz1m	366	18	and	and	CC
cord-306948-wkisfz1m	366	19	Snijder	Snijder	NNP
cord-306948-wkisfz1m	366	20	,	,	,
cord-306948-wkisfz1m	366	21	2010	2010	CD
cord-306948-wkisfz1m	366	22	;	;	:
cord-306948-wkisfz1m	366	23	Snijder	Snijder	NNP
cord-306948-wkisfz1m	366	24	et	et	NNP
cord-306948-wkisfz1m	366	25	al	al	NNP
cord-306948-wkisfz1m	366	26	.	.	NNP
cord-306948-wkisfz1m	366	27	,	,	,
cord-306948-wkisfz1m	366	28	2013	2013	CD
cord-306948-wkisfz1m	366	29	;	;	:
cord-306948-wkisfz1m	366	30	Xue	Xue	NNP
cord-306948-wkisfz1m	366	31	et	et	FW
cord-306948-wkisfz1m	366	32	al	al	NNP
cord-306948-wkisfz1m	366	33	.	.	NNP
cord-306948-wkisfz1m	366	34	,	,	,
cord-306948-wkisfz1m	366	35	2010	2010	CD
cord-306948-wkisfz1m	366	36	)	)	-RRB-
cord-306948-wkisfz1m	366	37	.	.	.
cord-306948-wkisfz1m	367	1	By	by	IN
cord-306948-wkisfz1m	367	2	deleting	delete	VBG
cord-306948-wkisfz1m	367	3	from	from	IN
cord-306948-wkisfz1m	367	4	the	the	DT
cord-306948-wkisfz1m	367	5	genome	genome	NN
cord-306948-wkisfz1m	367	6	,	,	,
cord-306948-wkisfz1m	367	7	nsp1	nsp1	NN
cord-306948-wkisfz1m	367	8	is	be	VBZ
cord-306948-wkisfz1m	367	9	shown	show	VBN
cord-306948-wkisfz1m	367	10	to	to	TO
cord-306948-wkisfz1m	367	11	be	be	VB
cord-306948-wkisfz1m	367	12	dispensable	dispensable	JJ
cord-306948-wkisfz1m	367	13	for	for	IN
cord-306948-wkisfz1m	367	14	genome	genome	NN
cord-306948-wkisfz1m	367	15	replication	replication	NN
cord-306948-wkisfz1m	367	16	but	but	CC
cord-306948-wkisfz1m	367	17	crucial	crucial	JJ
cord-306948-wkisfz1m	367	18	for	for	IN
cord-306948-wkisfz1m	367	19	mRNA	mRNA	NNP
cord-306948-wkisfz1m	367	20	transcription	transcription	NN
cord-306948-wkisfz1m	367	21	.	.	.
cord-306948-wkisfz1m	368	1	Mutation	mutation	NN
cord-306948-wkisfz1m	368	2	in	in	IN
cord-306948-wkisfz1m	368	3	the	the	DT
cord-306948-wkisfz1m	368	4	catalytic	catalytic	JJ
cord-306948-wkisfz1m	368	5	sites	site	NNS
cord-306948-wkisfz1m	368	6	of	of	IN
cord-306948-wkisfz1m	368	7	PLP1	PLP1	NNP
cord-306948-wkisfz1m	368	8	impairs	impair	VBZ
cord-306948-wkisfz1m	368	9	both	both	DT
cord-306948-wkisfz1m	368	10	viral	viral	JJ
cord-306948-wkisfz1m	368	11	genome	genome	NN
cord-306948-wkisfz1m	368	12	and	and	CC
cord-306948-wkisfz1m	368	13	mRNA	mRNA	NNP
cord-306948-wkisfz1m	368	14	synthesis	synthesis	NN
cord-306948-wkisfz1m	368	15	as	as	RB
cord-306948-wkisfz1m	368	16	well	well	RB
cord-306948-wkisfz1m	368	17	as	as	IN
cord-306948-wkisfz1m	368	18	the	the	DT
cord-306948-wkisfz1m	368	19	cleavage	cleavage	NN
cord-306948-wkisfz1m	368	20	between	between	IN
cord-306948-wkisfz1m	368	21	nsp1	nsp1	NNS
cord-306948-wkisfz1m	368	22	and	and	CC
cord-306948-wkisfz1m	368	23	nsp2	nsp2	NN
cord-306948-wkisfz1m	368	24	.	.	.
cord-306948-wkisfz1m	369	1	Mutations	mutation	NNS
cord-306948-wkisfz1m	369	2	in	in	IN
cord-306948-wkisfz1m	369	3	the	the	DT
cord-306948-wkisfz1m	369	4	zinc	zinc	NN
cord-306948-wkisfz1m	369	5	finger	finger	NN
cord-306948-wkisfz1m	369	6	motif	motif	NN
cord-306948-wkisfz1m	369	7	abolished	abolish	VBD
cord-306948-wkisfz1m	369	8	the	the	DT
cord-306948-wkisfz1m	369	9	mRNA	mRNA	NNP
cord-306948-wkisfz1m	369	10	transcription	transcription	NN
cord-306948-wkisfz1m	369	11	,	,	,
cord-306948-wkisfz1m	369	12	whereas	whereas	IN
cord-306948-wkisfz1m	369	13	genome	genome	NN
cord-306948-wkisfz1m	369	14	replication	replication	NN
cord-306948-wkisfz1m	369	15	was	be	VBD
cord-306948-wkisfz1m	369	16	not	not	RB
cord-306948-wkisfz1m	369	17	affected	affect	VBN
cord-306948-wkisfz1m	369	18	(	(	-LRB-
cord-306948-wkisfz1m	369	19	Tijms	Tijms	NNP
cord-306948-wkisfz1m	369	20	et	et	NNP
cord-306948-wkisfz1m	369	21	al	al	NNP
cord-306948-wkisfz1m	369	22	.	.	NNP
cord-306948-wkisfz1m	369	23	,	,	,
cord-306948-wkisfz1m	369	24	2001	2001	CD
cord-306948-wkisfz1m	370	1	(	(	-LRB-
cord-306948-wkisfz1m	370	2	Tijms	Tijms	NNP
cord-306948-wkisfz1m	370	3	et	et	NNP
cord-306948-wkisfz1m	370	4	al	al	NNP
cord-306948-wkisfz1m	370	5	.	.	NNP
cord-306948-wkisfz1m	370	6	,	,	,
cord-306948-wkisfz1m	370	7	,	,	,
cord-306948-wkisfz1m	370	8	2007	2007	CD
cord-306948-wkisfz1m	370	9	.	.	.
cord-306948-wkisfz1m	371	1	When	when	WRB
cord-306948-wkisfz1m	371	2	the	the	DT
cord-306948-wkisfz1m	371	3	catalytic	catalytic	JJ
cord-306948-wkisfz1m	371	4	sites	site	NNS
cord-306948-wkisfz1m	371	5	of	of	IN
cord-306948-wkisfz1m	371	6	PLP1a	PLP1a	NNS
cord-306948-wkisfz1m	371	7	are	be	VBP
cord-306948-wkisfz1m	371	8	mutated	mutate	VBN
cord-306948-wkisfz1m	371	9	using	use	VBG
cord-306948-wkisfz1m	371	10	a	a	DT
cord-306948-wkisfz1m	371	11	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	371	12	infectious	infectious	JJ
cord-306948-wkisfz1m	371	13	clone	clone	NN
cord-306948-wkisfz1m	371	14	,	,	,
cord-306948-wkisfz1m	371	15	the	the	DT
cord-306948-wkisfz1m	371	16	proteinase	proteinase	NN
cord-306948-wkisfz1m	371	17	activity	activity	NN
cord-306948-wkisfz1m	371	18	disappears	disappear	VBZ
cord-306948-wkisfz1m	371	19	and	and	CC
cord-306948-wkisfz1m	371	20	mRNA	mRNA	NNP
cord-306948-wkisfz1m	371	21	synthesis	synthesis	NN
cord-306948-wkisfz1m	371	22	is	be	VBZ
cord-306948-wkisfz1m	371	23	completely	completely	RB
cord-306948-wkisfz1m	371	24	blocked	block	VBN
cord-306948-wkisfz1m	371	25	.	.	.
cord-306948-wkisfz1m	372	1	In	in	IN
cord-306948-wkisfz1m	372	2	contrast	contrast	NN
cord-306948-wkisfz1m	372	3	,	,	,
cord-306948-wkisfz1m	372	4	mutations	mutation	NNS
cord-306948-wkisfz1m	372	5	at	at	IN
cord-306948-wkisfz1m	372	6	the	the	DT
cord-306948-wkisfz1m	372	7	PLP1b	PLP1b	NNP
cord-306948-wkisfz1m	372	8	catalytic	catalytic	JJ
cord-306948-wkisfz1m	372	9	sites	site	NNS
cord-306948-wkisfz1m	372	10	result	result	VBP
cord-306948-wkisfz1m	372	11	in	in	IN
cord-306948-wkisfz1m	372	12	no	no	DT
cord-306948-wkisfz1m	372	13	mRNA	mRNA	NNP
cord-306948-wkisfz1m	372	14	synthesis	synthesis	NN
cord-306948-wkisfz1m	372	15	and	and	CC
cord-306948-wkisfz1m	372	16	no	no	DT
cord-306948-wkisfz1m	372	17	viral	viral	JJ
cord-306948-wkisfz1m	372	18	infectivity	infectivity	NN
cord-306948-wkisfz1m	372	19	,	,	,
cord-306948-wkisfz1m	372	20	indicating	indicate	VBG
cord-306948-wkisfz1m	372	21	that	that	IN
cord-306948-wkisfz1m	372	22	the	the	DT
cord-306948-wkisfz1m	372	23	normal	normal	JJ
cord-306948-wkisfz1m	372	24	cleavage	cleavage	NN
cord-306948-wkisfz1m	372	25	of	of	IN
cord-306948-wkisfz1m	372	26	nsp1	nsp1	NNS
cord-306948-wkisfz1m	372	27	and	and	CC
cord-306948-wkisfz1m	372	28	nsp2	nsp2	NN
cord-306948-wkisfz1m	372	29	is	be	VBZ
cord-306948-wkisfz1m	372	30	critical	critical	JJ
cord-306948-wkisfz1m	372	31	for	for	IN
cord-306948-wkisfz1m	372	32	viral	viral	JJ
cord-306948-wkisfz1m	372	33	replication	replication	NN
cord-306948-wkisfz1m	372	34	(	(	-LRB-
cord-306948-wkisfz1m	372	35	Kroese	Kroese	NNP
cord-306948-wkisfz1m	372	36	et	et	NNP
cord-306948-wkisfz1m	372	37	al	al	NNP
cord-306948-wkisfz1m	372	38	.	.	NNP
cord-306948-wkisfz1m	372	39	,	,	,
cord-306948-wkisfz1m	372	40	2008	2008	CD
cord-306948-wkisfz1m	372	41	)	)	-RRB-
cord-306948-wkisfz1m	372	42	.	.	.
cord-306948-wkisfz1m	373	1	To	to	TO
cord-306948-wkisfz1m	373	2	design	design	VB
cord-306948-wkisfz1m	373	3	effective	effective	JJ
cord-306948-wkisfz1m	373	4	vaccine	vaccine	NN
cord-306948-wkisfz1m	373	5	candidates	candidate	NNS
cord-306948-wkisfz1m	373	6	that	that	WDT
cord-306948-wkisfz1m	373	7	may	may	MD
cord-306948-wkisfz1m	373	8	be	be	VB
cord-306948-wkisfz1m	373	9	useful	useful	JJ
cord-306948-wkisfz1m	373	10	to	to	IN
cord-306948-wkisfz1m	373	11	overcoming	overcome	VBG
cord-306948-wkisfz1m	373	12	antigenic	antigenic	JJ
cord-306948-wkisfz1m	373	13	heterogeneity	heterogeneity	NN
cord-306948-wkisfz1m	373	14	of	of	IN
cord-306948-wkisfz1m	373	15	PRRS	PRRS	NNP
cord-306948-wkisfz1m	373	16	,	,	,
cord-306948-wkisfz1m	373	17	extensive	extensive	JJ
cord-306948-wkisfz1m	373	18	studies	study	NNS
cord-306948-wkisfz1m	373	19	have	have	VBP
cord-306948-wkisfz1m	373	20	been	be	VBN
cord-306948-wkisfz1m	373	21	conducted	conduct	VBN
cord-306948-wkisfz1m	373	22	to	to	TO
cord-306948-wkisfz1m	373	23	eliminate	eliminate	VB
cord-306948-wkisfz1m	373	24	the	the	DT
cord-306948-wkisfz1m	373	25	IFN	IFN	NNP
cord-306948-wkisfz1m	373	26	antagonistic	antagonistic	JJ
cord-306948-wkisfz1m	373	27	function	function	NN
cord-306948-wkisfz1m	373	28	from	from	IN
cord-306948-wkisfz1m	373	29	the	the	DT
cord-306948-wkisfz1m	373	30	virus	virus	NN
cord-306948-wkisfz1m	373	31	(	(	-LRB-
cord-306948-wkisfz1m	373	32	see	see	VB
cord-306948-wkisfz1m	373	33	reviews	review	NNS
cord-306948-wkisfz1m	373	34	Snijder	Snijder	NNP
cord-306948-wkisfz1m	373	35	et	et	NNP
cord-306948-wkisfz1m	373	36	al	al	NNP
cord-306948-wkisfz1m	373	37	.	.	NNP
cord-306948-wkisfz1m	373	38	,	,	,
cord-306948-wkisfz1m	373	39	2013	2013	CD
cord-306948-wkisfz1m	373	40	;	;	:
cord-306948-wkisfz1m	373	41	Sun	Sun	NNP
cord-306948-wkisfz1m	373	42	et	et	NNP
cord-306948-wkisfz1m	373	43	al	al	NNP
cord-306948-wkisfz1m	373	44	.	.	NNP
cord-306948-wkisfz1m	373	45	,	,	,
cord-306948-wkisfz1m	373	46	2012a	2012a	CD
cord-306948-wkisfz1m	373	47	;	;	:
cord-306948-wkisfz1m	373	48	Yoo	Yoo	NNP
cord-306948-wkisfz1m	373	49	et	et	NNP
cord-306948-wkisfz1m	373	50	al	al	NNP
cord-306948-wkisfz1m	373	51	.	.	NNP
cord-306948-wkisfz1m	373	52	,	,	,
cord-306948-wkisfz1m	373	53	2010	2010	CD
cord-306948-wkisfz1m	373	54	)	)	-RRB-
cord-306948-wkisfz1m	373	55	.	.	.
cord-306948-wkisfz1m	374	1	Among	among	IN
cord-306948-wkisfz1m	374	2	viral	viral	JJ
cord-306948-wkisfz1m	374	3	proteins	protein	NNS
cord-306948-wkisfz1m	374	4	,	,	,
cord-306948-wkisfz1m	374	5	nsp1a	nsp1a	NNS
cord-306948-wkisfz1m	374	6	and	and	CC
cord-306948-wkisfz1m	374	7	nsp1b	nsp1b	NNP
cord-306948-wkisfz1m	374	8	have	have	VBP
cord-306948-wkisfz1m	374	9	been	be	VBN
cord-306948-wkisfz1m	374	10	identified	identify	VBN
cord-306948-wkisfz1m	374	11	as	as	IN
cord-306948-wkisfz1m	374	12	potent	potent	JJ
cord-306948-wkisfz1m	374	13	IFN	IFN	NNP
cord-306948-wkisfz1m	374	14	analogists	analogist	NNS
cord-306948-wkisfz1m	374	15	(	(	-LRB-
cord-306948-wkisfz1m	374	16	Beura	Beura	NNP
cord-306948-wkisfz1m	374	17	et	et	NNP
cord-306948-wkisfz1m	374	18	al	al	NNP
cord-306948-wkisfz1m	374	19	.	.	NNP
cord-306948-wkisfz1m	374	20	,	,	,
cord-306948-wkisfz1m	374	21	2010	2010	CD
cord-306948-wkisfz1m	374	22	;	;	.
cord-306948-wkisfz1m	375	1	Chen	Chen	NNP
cord-306948-wkisfz1m	375	2	et	et	NNP
cord-306948-wkisfz1m	375	3	al	al	NNP
cord-306948-wkisfz1m	375	4	.	.	.
cord-306948-wkisfz1m	376	1	,	,	,
cord-306948-wkisfz1m	376	2	2010a	2010a	NNS
cord-306948-wkisfz1m	376	3	;	;	:
cord-306948-wkisfz1m	376	4	Han	Han	NNP
cord-306948-wkisfz1m	376	5	et	et	NNP
cord-306948-wkisfz1m	376	6	al	al	NNP
cord-306948-wkisfz1m	376	7	.	.	.
cord-306948-wkisfz1m	377	1	,	,	,
cord-306948-wkisfz1m	377	2	2013	2013	CD
cord-306948-wkisfz1m	378	1	Han	Han	NNP
cord-306948-wkisfz1m	378	2	et	et	NNP
cord-306948-wkisfz1m	378	3	al	al	NNP
cord-306948-wkisfz1m	378	4	.	.	.
cord-306948-wkisfz1m	379	1	,	,	,
cord-306948-wkisfz1m	379	2	,	,	,
cord-306948-wkisfz1m	379	3	2014	2014	CD
cord-306948-wkisfz1m	379	4	Kim	Kim	NNP
cord-306948-wkisfz1m	379	5	et	et	NNP
cord-306948-wkisfz1m	379	6	al	al	NNP
cord-306948-wkisfz1m	379	7	.	.	NNP
cord-306948-wkisfz1m	379	8	,	,	,
cord-306948-wkisfz1m	379	9	2010	2010	CD
cord-306948-wkisfz1m	379	10	;	;	:
cord-306948-wkisfz1m	379	11	Song	Song	NNP
cord-306948-wkisfz1m	379	12	et	et	FW
cord-306948-wkisfz1m	379	13	al	al	NNP
cord-306948-wkisfz1m	379	14	.	.	NNP
cord-306948-wkisfz1m	379	15	,	,	,
cord-306948-wkisfz1m	379	16	2010	2010	CD
cord-306948-wkisfz1m	379	17	)	)	-RRB-
cord-306948-wkisfz1m	379	18	.	.	.
cord-306948-wkisfz1m	380	1	Subsequent	subsequent	JJ
cord-306948-wkisfz1m	380	2	studies	study	NNS
cord-306948-wkisfz1m	380	3	have	have	VBP
cord-306948-wkisfz1m	380	4	identified	identify	VBN
cord-306948-wkisfz1m	380	5	specific	specific	JJ
cord-306948-wkisfz1m	380	6	residues	residue	NNS
cord-306948-wkisfz1m	380	7	regulating	regulate	VBG
cord-306948-wkisfz1m	380	8	the	the	DT
cord-306948-wkisfz1m	380	9	IFN	IFN	NNP
cord-306948-wkisfz1m	380	10	antagonism	antagonism	NN
cord-306948-wkisfz1m	380	11	,	,	,
cord-306948-wkisfz1m	380	12	and	and	CC
cord-306948-wkisfz1m	380	13	a	a	DT
cord-306948-wkisfz1m	380	14	mutant	mutant	JJ
cord-306948-wkisfz1m	380	15	virus	virus	NN
cord-306948-wkisfz1m	380	16	with	with	IN
cord-306948-wkisfz1m	380	17	a	a	DT
cord-306948-wkisfz1m	380	18	stretch	stretch	NN
cord-306948-wkisfz1m	380	19	of	of	IN
cord-306948-wkisfz1m	380	20	alanine	alanine	JJ
cord-306948-wkisfz1m	380	21	substitution	substitution	NN
cord-306948-wkisfz1m	380	22	at	at	IN
cord-306948-wkisfz1m	380	23	positions	position	NNS
cord-306948-wkisfz1m	380	24	16	16	CD
cord-306948-wkisfz1m	380	25	-	-	SYM
cord-306948-wkisfz1m	380	26	20	20	CD
cord-306948-wkisfz1m	380	27	of	of	IN
cord-306948-wkisfz1m	380	28	nsp1b	nsp1b	NNP
cord-306948-wkisfz1m	380	29	showed	show	VBD
cord-306948-wkisfz1m	380	30	the	the	DT
cord-306948-wkisfz1m	380	31	loss	loss	NN
cord-306948-wkisfz1m	380	32	of	of	IN
cord-306948-wkisfz1m	380	33	IFN	IFN	NNP
cord-306948-wkisfz1m	380	34	suppression	suppression	NN
cord-306948-wkisfz1m	380	35	.	.	.
cord-306948-wkisfz1m	381	1	In	in	IN
cord-306948-wkisfz1m	381	2	another	another	DT
cord-306948-wkisfz1m	381	3	study	study	NN
cord-306948-wkisfz1m	381	4	,	,	,
cord-306948-wkisfz1m	381	5	K124	K124	NNPS
cord-306948-wkisfz1m	381	6	and	and	CC
cord-306948-wkisfz1m	381	7	R128	R128	NNPS
cord-306948-wkisfz1m	381	8	were	be	VBD
cord-306948-wkisfz1m	381	9	mutated	mutate	VBN
cord-306948-wkisfz1m	381	10	to	to	TO
cord-306948-wkisfz1m	381	11	release	release	VB
cord-306948-wkisfz1m	381	12	the	the	DT
cord-306948-wkisfz1m	381	13	surface	surface	NN
cord-306948-wkisfz1m	381	14	accessibility	accessibility	NN
cord-306948-wkisfz1m	381	15	of	of	IN
cord-306948-wkisfz1m	381	16	nsp1b	nsp1b	NN
cord-306948-wkisfz1m	381	17	,	,	,
cord-306948-wkisfz1m	381	18	and	and	CC
cord-306948-wkisfz1m	381	19	mutant	mutant	JJ
cord-306948-wkisfz1m	381	20	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	381	21	impaired	impair	VBD
cord-306948-wkisfz1m	381	22	the	the	DT
cord-306948-wkisfz1m	381	23	IFN	IFN	NNP
cord-306948-wkisfz1m	381	24	antagonism	antagonism	NN
cord-306948-wkisfz1m	381	25	(	(	-LRB-
cord-306948-wkisfz1m	381	26	Li	Li	NNP
cord-306948-wkisfz1m	381	27	et	et	NNP
cord-306948-wkisfz1m	381	28	al	al	NNP
cord-306948-wkisfz1m	381	29	.	.	NNP
cord-306948-wkisfz1m	381	30	,	,	,
cord-306948-wkisfz1m	381	31	2013	2013	CD
cord-306948-wkisfz1m	381	32	)	)	-RRB-
cord-306948-wkisfz1m	381	33	.	.	.
cord-306948-wkisfz1m	382	1	Motifs	Motifs	NNP
cord-306948-wkisfz1m	382	2	in	in	IN
cord-306948-wkisfz1m	382	3	the	the	DT
cord-306948-wkisfz1m	382	4	N	N	NNP
cord-306948-wkisfz1m	382	5	protein	protein	NN
cord-306948-wkisfz1m	382	6	have	have	VBP
cord-306948-wkisfz1m	382	7	broadly	broadly	RB
cord-306948-wkisfz1m	382	8	been	be	VBN
cord-306948-wkisfz1m	382	9	studied	study	VBN
cord-306948-wkisfz1m	382	10	using	use	VBG
cord-306948-wkisfz1m	382	11	mutant	mutant	JJ
cord-306948-wkisfz1m	382	12	viruses	virus	NNS
cord-306948-wkisfz1m	382	13	.	.	.
cord-306948-wkisfz1m	383	1	The	the	DT
cord-306948-wkisfz1m	383	2	importance	importance	NN
cord-306948-wkisfz1m	383	3	of	of	IN
cord-306948-wkisfz1m	383	4	N	n	CD
cord-306948-wkisfz1m	383	5	protein	protein	NN
cord-306948-wkisfz1m	383	6	dimerization	dimerization	NN
cord-306948-wkisfz1m	383	7	has	have	VBZ
cord-306948-wkisfz1m	383	8	been	be	VBN
cord-306948-wkisfz1m	383	9	examined	examine	VBN
cord-306948-wkisfz1m	383	10	by	by	IN
cord-306948-wkisfz1m	383	11	mutating	mutate	VBG
cord-306948-wkisfz1m	383	12	C23S	c23s	NN
cord-306948-wkisfz1m	383	13	which	which	WDT
cord-306948-wkisfz1m	383	14	is	be	VBZ
cord-306948-wkisfz1m	383	15	responsible	responsible	JJ
cord-306948-wkisfz1m	383	16	for	for	IN
cord-306948-wkisfz1m	383	17	the	the	DT
cord-306948-wkisfz1m	383	18	covalent	covalent	JJ
cord-306948-wkisfz1m	383	19	interaction	interaction	NN
cord-306948-wkisfz1m	383	20	between	between	IN
cord-306948-wkisfz1m	383	21	N	n	CD
cord-306948-wkisfz1m	383	22	proteins	protein	NNS
cord-306948-wkisfz1m	383	23	.	.	.
cord-306948-wkisfz1m	384	1	Mutant	mutant	JJ
cord-306948-wkisfz1m	384	2	viruses	virus	NNS
cord-306948-wkisfz1m	384	3	of	of	IN
cord-306948-wkisfz1m	384	4	C23S	c23s	NN
cord-306948-wkisfz1m	384	5	,	,	,
cord-306948-wkisfz1m	384	6	C75S	C75S	NNP
cord-306948-wkisfz1m	384	7	,	,	,
cord-306948-wkisfz1m	384	8	and	and	CC
cord-306948-wkisfz1m	384	9	C90S	C90S	NNP
cord-306948-wkisfz1m	384	10	were	be	VBD
cord-306948-wkisfz1m	384	11	constructed	construct	VBN
cord-306948-wkisfz1m	384	12	,	,	,
cord-306948-wkisfz1m	384	13	and	and	CC
cord-306948-wkisfz1m	384	14	with	with	IN
cord-306948-wkisfz1m	384	15	the	the	DT
cord-306948-wkisfz1m	384	16	exception	exception	NN
cord-306948-wkisfz1m	384	17	of	of	IN
cord-306948-wkisfz1m	384	18	C75S	C75S	NNP
cord-306948-wkisfz1m	384	19	,	,	,
cord-306948-wkisfz1m	384	20	both	both	DT
cord-306948-wkisfz1m	384	21	C23S	c23s	VBP
cord-306948-wkisfz1m	384	22	and	and	CC
cord-306948-wkisfz1m	384	23	C90S	c90s	XX
cord-306948-wkisfz1m	384	24	completely	completely	RB
cord-306948-wkisfz1m	384	25	lost	lose	VBD
cord-306948-wkisfz1m	384	26	their	-PRON-	PRP$
cord-306948-wkisfz1m	384	27	infectivity	infectivity	NN
cord-306948-wkisfz1m	384	28	.	.	.
cord-306948-wkisfz1m	385	1	In	in	IN
cord-306948-wkisfz1m	385	2	another	another	DT
cord-306948-wkisfz1m	385	3	study	study	NN
cord-306948-wkisfz1m	385	4	however	however	RB
cord-306948-wkisfz1m	385	5	,	,	,
cord-306948-wkisfz1m	385	6	the	the	DT
cord-306948-wkisfz1m	385	7	replacement	replacement	NN
cord-306948-wkisfz1m	385	8	of	of	IN
cord-306948-wkisfz1m	385	9	cysteines	cysteine	NNS
cord-306948-wkisfz1m	385	10	within	within	IN
cord-306948-wkisfz1m	385	11	N	n	CD
cord-306948-wkisfz1m	385	12	protein	protein	NN
cord-306948-wkisfz1m	385	13	,	,	,
cord-306948-wkisfz1m	385	14	either	either	CC
cord-306948-wkisfz1m	385	15	singly	singly	RB
cord-306948-wkisfz1m	385	16	or	or	CC
cord-306948-wkisfz1m	385	17	in	in	IN
cord-306948-wkisfz1m	385	18	combination	combination	NN
cord-306948-wkisfz1m	385	19	,	,	,
cord-306948-wkisfz1m	385	20	did	do	VBD
cord-306948-wkisfz1m	385	21	not	not	RB
cord-306948-wkisfz1m	385	22	impair	impair	VB
cord-306948-wkisfz1m	385	23	the	the	DT
cord-306948-wkisfz1m	385	24	growth	growth	NN
cord-306948-wkisfz1m	385	25	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	385	26	according	accord	VBG
cord-306948-wkisfz1m	385	27	.	.	.
cord-306948-wkisfz1m	386	1	Genome	genome	NN
cord-306948-wkisfz1m	386	2	replication	replication	NN
cord-306948-wkisfz1m	386	3	and	and	CC
cord-306948-wkisfz1m	386	4	mRNA	mrna	NN
cord-306948-wkisfz1m	386	5	transcription	transcription	NN
cord-306948-wkisfz1m	386	6	were	be	VBD
cord-306948-wkisfz1m	386	7	normal	normal	JJ
cord-306948-wkisfz1m	386	8	for	for	IN
cord-306948-wkisfz1m	386	9	both	both	DT
cord-306948-wkisfz1m	386	10	mutants	mutant	NNS
cord-306948-wkisfz1m	386	11	,	,	,
cord-306948-wkisfz1m	386	12	suggesting	suggest	VBG
cord-306948-wkisfz1m	386	13	the	the	DT
cord-306948-wkisfz1m	386	14	dimerization	dimerization	NN
cord-306948-wkisfz1m	386	15	of	of	IN
cord-306948-wkisfz1m	386	16	N	n	CD
cord-306948-wkisfz1m	386	17	may	may	MD
cord-306948-wkisfz1m	386	18	be	be	VB
cord-306948-wkisfz1m	386	19	important	important	JJ
cord-306948-wkisfz1m	386	20	for	for	IN
cord-306948-wkisfz1m	386	21	particle	particle	NN
cord-306948-wkisfz1m	386	22	assembly	assembly	NN
cord-306948-wkisfz1m	386	23	or	or	CC
cord-306948-wkisfz1m	386	24	maturation	maturation	NN
cord-306948-wkisfz1m	386	25	.	.	.
cord-306948-wkisfz1m	387	1	The	the	DT
cord-306948-wkisfz1m	387	2	nuclear	nuclear	JJ
cord-306948-wkisfz1m	387	3	localization	localization	NN
cord-306948-wkisfz1m	387	4	signal	signal	NN
cord-306948-wkisfz1m	387	5	(	(	-LRB-
cord-306948-wkisfz1m	387	6	NLS	NLS	NNP
cord-306948-wkisfz1m	387	7	)	)	-RRB-
cord-306948-wkisfz1m	387	8	of	of	IN
cord-306948-wkisfz1m	387	9	N	N	NNP
cord-306948-wkisfz1m	387	10	was	be	VBD
cord-306948-wkisfz1m	387	11	also	also	RB
cord-306948-wkisfz1m	387	12	mutated	mutate	VBN
cord-306948-wkisfz1m	387	13	to	to	TO
cord-306948-wkisfz1m	387	14	examine	examine	VB
cord-306948-wkisfz1m	387	15	the	the	DT
cord-306948-wkisfz1m	387	16	biological	biological	JJ
cord-306948-wkisfz1m	387	17	consequence	consequence	NN
cord-306948-wkisfz1m	387	18	of	of	IN
cord-306948-wkisfz1m	387	19	N	n	CD
cord-306948-wkisfz1m	387	20	in	in	IN
cord-306948-wkisfz1m	387	21	the	the	DT
cord-306948-wkisfz1m	387	22	nucleus	nucleus	NN
cord-306948-wkisfz1m	387	23	in	in	IN
cord-306948-wkisfz1m	387	24	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	387	25	-	-	HYPH
cord-306948-wkisfz1m	387	26	infected	infect	VBN
cord-306948-wkisfz1m	387	27	cells	cell	NNS
cord-306948-wkisfz1m	387	28	.	.	.
cord-306948-wkisfz1m	388	1	Compared	compare	VBN
cord-306948-wkisfz1m	388	2	to	to	IN
cord-306948-wkisfz1m	388	3	wild	wild	JJ
cord-306948-wkisfz1m	388	4	-	-	HYPH
cord-306948-wkisfz1m	388	5	type	type	NN
cord-306948-wkisfz1m	388	6	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	388	7	,	,	,
cord-306948-wkisfz1m	388	8	NLS	nls	NN
cord-306948-wkisfz1m	388	9	-	-	HYPH
cord-306948-wkisfz1m	388	10	null	null	JJ
cord-306948-wkisfz1m	388	11	mutant	mutant	JJ
cord-306948-wkisfz1m	388	12	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	388	13	was	be	VBD
cord-306948-wkisfz1m	388	14	attenuated	attenuate	VBN
cord-306948-wkisfz1m	388	15	in	in	IN
cord-306948-wkisfz1m	388	16	pigs	pig	NNS
cord-306948-wkisfz1m	388	17	and	and	CC
cord-306948-wkisfz1m	388	18	produced	produce	VBD
cord-306948-wkisfz1m	388	19	a	a	DT
cord-306948-wkisfz1m	388	20	significantly	significantly	RB
cord-306948-wkisfz1m	388	21	shorter	short	JJR
cord-306948-wkisfz1m	388	22	mean	mean	JJ
cord-306948-wkisfz1m	388	23	duration	duration	NN
cord-306948-wkisfz1m	388	24	of	of	IN
cord-306948-wkisfz1m	388	25	viremia	viremia	NN
cord-306948-wkisfz1m	388	26	and	and	CC
cord-306948-wkisfz1m	388	27	higher	high	JJR
cord-306948-wkisfz1m	388	28	titers	titer	NNS
cord-306948-wkisfz1m	388	29	of	of	IN
cord-306948-wkisfz1m	388	30	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	388	31	antibodies	antibody	NNS
cord-306948-wkisfz1m	388	32	Pei	Pei	NNP
cord-306948-wkisfz1m	388	33	et	et	NNP
cord-306948-wkisfz1m	388	34	al	al	NNP
cord-306948-wkisfz1m	388	35	.	.	NNP
cord-306948-wkisfz1m	388	36	,	,	,
cord-306948-wkisfz1m	388	37	2008	2008	CD
cord-306948-wkisfz1m	388	38	)	)	-RRB-
cord-306948-wkisfz1m	388	39	,	,	,
cord-306948-wkisfz1m	388	40	demonstrating	demonstrate	VBG
cord-306948-wkisfz1m	388	41	that	that	IN
cord-306948-wkisfz1m	388	42	the	the	DT
cord-306948-wkisfz1m	388	43	N	N	NNP
cord-306948-wkisfz1m	388	44	protein	protein	NN
cord-306948-wkisfz1m	388	45	nuclear	nuclear	JJ
cord-306948-wkisfz1m	388	46	localization	localization	NN
cord-306948-wkisfz1m	388	47	is	be	VBZ
cord-306948-wkisfz1m	388	48	a	a	DT
cord-306948-wkisfz1m	388	49	virulence	virulence	NN
cord-306948-wkisfz1m	388	50	factor	factor	NN
cord-306948-wkisfz1m	388	51	.	.	.
cord-306948-wkisfz1m	389	1	As	as	IN
cord-306948-wkisfz1m	389	2	an	an	DT
cord-306948-wkisfz1m	389	3	emerged	emerge	VBN
cord-306948-wkisfz1m	389	4	and	and	CC
cord-306948-wkisfz1m	389	5	re	re	VBN
cord-306948-wkisfz1m	389	6	-	-	JJ
cord-306948-wkisfz1m	389	7	emerging	emerge	VBG
cord-306948-wkisfz1m	389	8	disease	disease	NN
cord-306948-wkisfz1m	389	9	in	in	IN
cord-306948-wkisfz1m	389	10	swine	swine	NN
cord-306948-wkisfz1m	389	11	,	,	,
cord-306948-wkisfz1m	389	12	PRRS	PRRS	NNP
cord-306948-wkisfz1m	389	13	has	have	VBZ
cord-306948-wkisfz1m	389	14	extensively	extensively	RB
cord-306948-wkisfz1m	389	15	been	be	VBN
cord-306948-wkisfz1m	389	16	studied	study	VBN
cord-306948-wkisfz1m	389	17	for	for	IN
cord-306948-wkisfz1m	389	18	molecular	molecular	JJ
cord-306948-wkisfz1m	389	19	biology	biology	NN
cord-306948-wkisfz1m	389	20	,	,	,
cord-306948-wkisfz1m	389	21	immunology	immunology	NN
cord-306948-wkisfz1m	389	22	,	,	,
cord-306948-wkisfz1m	389	23	and	and	CC
cord-306948-wkisfz1m	389	24	prevention	prevention	NN
cord-306948-wkisfz1m	389	25	.	.	.
cord-306948-wkisfz1m	390	1	The	the	DT
cord-306948-wkisfz1m	390	2	unusual	unusual	JJ
cord-306948-wkisfz1m	390	3	immune	immune	JJ
cord-306948-wkisfz1m	390	4	responses	response	NNS
cord-306948-wkisfz1m	390	5	in	in	IN
cord-306948-wkisfz1m	390	6	pigs	pig	NNS
cord-306948-wkisfz1m	390	7	and	and	CC
cord-306948-wkisfz1m	390	8	antigenic	antigenic	JJ
cord-306948-wkisfz1m	390	9	heterogeneity	heterogeneity	NN
cord-306948-wkisfz1m	390	10	of	of	IN
cord-306948-wkisfz1m	390	11	the	the	DT
cord-306948-wkisfz1m	390	12	virus	virus	NN
cord-306948-wkisfz1m	390	13	are	be	VBP
cord-306948-wkisfz1m	390	14	two	two	CD
cord-306948-wkisfz1m	390	15	main	main	JJ
cord-306948-wkisfz1m	390	16	obstacles	obstacle	NNS
cord-306948-wkisfz1m	390	17	to	to	IN
cord-306948-wkisfz1m	390	18	developing	develop	VBG
cord-306948-wkisfz1m	390	19	a	a	DT
cord-306948-wkisfz1m	390	20	satisfactory	satisfactory	JJ
cord-306948-wkisfz1m	390	21	PRRS	PRRS	NNP
cord-306948-wkisfz1m	390	22	vaccine	vaccine	NN
cord-306948-wkisfz1m	390	23	.	.	.
cord-306948-wkisfz1m	391	1	The	the	DT
cord-306948-wkisfz1m	391	2	availability	availability	NN
cord-306948-wkisfz1m	391	3	of	of	IN
cord-306948-wkisfz1m	391	4	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	391	5	infectious	infectious	JJ
cord-306948-wkisfz1m	391	6	clones	clone	NNS
cord-306948-wkisfz1m	391	7	and	and	CC
cord-306948-wkisfz1m	391	8	recent	recent	JJ
cord-306948-wkisfz1m	391	9	advances	advance	NNS
cord-306948-wkisfz1m	391	10	in	in	IN
cord-306948-wkisfz1m	391	11	recombinant	recombinant	JJ
cord-306948-wkisfz1m	391	12	DNA	dna	NN
cord-306948-wkisfz1m	391	13	technology	technology	NN
cord-306948-wkisfz1m	391	14	have	have	VBP
cord-306948-wkisfz1m	391	15	made	make	VBN
cord-306948-wkisfz1m	391	16	possible	possible	JJ
cord-306948-wkisfz1m	391	17	to	to	TO
cord-306948-wkisfz1m	391	18	manipulate	manipulate	VB
cord-306948-wkisfz1m	391	19	the	the	DT
cord-306948-wkisfz1m	391	20	viral	viral	JJ
cord-306948-wkisfz1m	391	21	genome	genome	NN
cord-306948-wkisfz1m	391	22	to	to	TO
cord-306948-wkisfz1m	391	23	introduce	introduce	VB
cord-306948-wkisfz1m	391	24	specific	specific	JJ
cord-306948-wkisfz1m	391	25	mutations	mutation	NNS
cord-306948-wkisfz1m	391	26	to	to	IN
cord-306948-wkisfz1m	391	27	targeted	target	VBN
cord-306948-wkisfz1m	391	28	sequences	sequence	NNS
cord-306948-wkisfz1m	391	29	and	and	CC
cord-306948-wkisfz1m	391	30	to	to	TO
cord-306948-wkisfz1m	391	31	create	create	VB
cord-306948-wkisfz1m	391	32	genetically	genetically	RB
cord-306948-wkisfz1m	391	33	modified	modify	VBN
cord-306948-wkisfz1m	391	34	mutant	mutant	JJ
cord-306948-wkisfz1m	391	35	viruses	virus	NNS
cord-306948-wkisfz1m	391	36	.	.	.
cord-306948-wkisfz1m	392	1	Extensive	extensive	JJ
cord-306948-wkisfz1m	392	2	efforts	effort	NNS
cord-306948-wkisfz1m	392	3	have	have	VBP
cord-306948-wkisfz1m	392	4	been	be	VBN
cord-306948-wkisfz1m	392	5	applied	apply	VBN
cord-306948-wkisfz1m	392	6	to	to	IN
cord-306948-wkisfz1m	392	7	making	make	VBG
cord-306948-wkisfz1m	392	8	mutant	mutant	JJ
cord-306948-wkisfz1m	392	9	viruses	virus	NNS
cord-306948-wkisfz1m	392	10	with	with	IN
cord-306948-wkisfz1m	392	11	modified	modified	JJ
cord-306948-wkisfz1m	392	12	phenotypes	phenotype	NNS
cord-306948-wkisfz1m	392	13	of	of	IN
cord-306948-wkisfz1m	392	14	immune	immune	JJ
cord-306948-wkisfz1m	392	15	responses	response	NNS
cord-306948-wkisfz1m	392	16	including	include	VBG
cord-306948-wkisfz1m	392	17	the	the	DT
cord-306948-wkisfz1m	392	18	evasion	evasion	NN
cord-306948-wkisfz1m	392	19	of	of	IN
cord-306948-wkisfz1m	392	20	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	392	21	antibodies	antibody	NNS
cord-306948-wkisfz1m	392	22	and	and	CC
cord-306948-wkisfz1m	392	23	suppressed	suppress	VBN
cord-306948-wkisfz1m	392	24	innate	innate	JJ
cord-306948-wkisfz1m	392	25	immune	immune	JJ
cord-306948-wkisfz1m	392	26	responses	response	NNS
cord-306948-wkisfz1m	392	27	.	.	.
cord-306948-wkisfz1m	393	1	For	for	IN
cord-306948-wkisfz1m	393	2	viral	viral	JJ
cord-306948-wkisfz1m	393	3	heterogeneity	heterogeneity	NN
cord-306948-wkisfz1m	393	4	,	,	,
cord-306948-wkisfz1m	393	5	the	the	DT
cord-306948-wkisfz1m	393	6	RNA	RNA	NNP
cord-306948-wkisfz1m	393	7	-	-	HYPH
cord-306948-wkisfz1m	393	8	dependent	dependent	JJ
cord-306948-wkisfz1m	393	9	RNA	RNA	NNP
cord-306948-wkisfz1m	393	10	polymerase	polymerase	NN
cord-306948-wkisfz1m	393	11	(	(	-LRB-
cord-306948-wkisfz1m	393	12	RdRp	RdRp	NNP
cord-306948-wkisfz1m	393	13	)	)	-RRB-
cord-306948-wkisfz1m	393	14	is	be	VBZ
cord-306948-wkisfz1m	393	15	believed	believe	VBN
cord-306948-wkisfz1m	393	16	to	to	TO
cord-306948-wkisfz1m	393	17	cause	cause	VB
cord-306948-wkisfz1m	393	18	frequent	frequent	JJ
cord-306948-wkisfz1m	393	19	mutations	mutation	NNS
cord-306948-wkisfz1m	393	20	in	in	IN
cord-306948-wkisfz1m	393	21	the	the	DT
cord-306948-wkisfz1m	393	22	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	393	23	genome	genome	NN
cord-306948-wkisfz1m	393	24	.	.	.
cord-306948-wkisfz1m	394	1	Genetic	genetic	JJ
cord-306948-wkisfz1m	394	2	swapping	swapping	NN
cord-306948-wkisfz1m	394	3	or	or	CC
cord-306948-wkisfz1m	394	4	modifications	modification	NNS
cord-306948-wkisfz1m	394	5	of	of	IN
cord-306948-wkisfz1m	394	6	nsp9	nsp9	DT
cord-306948-wkisfz1m	394	7	,	,	,
cord-306948-wkisfz1m	394	8	the	the	DT
cord-306948-wkisfz1m	394	9	RdRp	RdRp	NNP
cord-306948-wkisfz1m	394	10	of	of	IN
cord-306948-wkisfz1m	394	11	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	394	12	,	,	,
cord-306948-wkisfz1m	394	13	may	may	MD
cord-306948-wkisfz1m	394	14	be	be	VB
cord-306948-wkisfz1m	394	15	studied	study	VBN
cord-306948-wkisfz1m	394	16	to	to	TO
cord-306948-wkisfz1m	394	17	make	make	VB
cord-306948-wkisfz1m	394	18	mutant	mutant	JJ
cord-306948-wkisfz1m	394	19	viruses	virus	NNS
cord-306948-wkisfz1m	394	20	with	with	IN
cord-306948-wkisfz1m	394	21	reduced	reduce	VBN
cord-306948-wkisfz1m	394	22	mutation	mutation	NN
cord-306948-wkisfz1m	394	23	rates	rate	NNS
cord-306948-wkisfz1m	394	24	during	during	IN
cord-306948-wkisfz1m	394	25	replication	replication	NN
cord-306948-wkisfz1m	394	26	.	.	.
cord-306948-wkisfz1m	395	1	The	the	DT
cord-306948-wkisfz1m	395	2	reverse	reverse	JJ
cord-306948-wkisfz1m	395	3	genetics	genetic	NNS
cord-306948-wkisfz1m	395	4	of	of	IN
cord-306948-wkisfz1m	395	5	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	395	6	is	be	VBZ
cord-306948-wkisfz1m	395	7	a	a	DT
cord-306948-wkisfz1m	395	8	powerful	powerful	JJ
cord-306948-wkisfz1m	395	9	genetic	genetic	JJ
cord-306948-wkisfz1m	395	10	tool	tool	NN
cord-306948-wkisfz1m	395	11	and	and	CC
cord-306948-wkisfz1m	395	12	has	have	VBZ
cord-306948-wkisfz1m	395	13	the	the	DT
cord-306948-wkisfz1m	395	14	potential	potential	NN
cord-306948-wkisfz1m	395	15	to	to	TO
cord-306948-wkisfz1m	395	16	apply	apply	VB
cord-306948-wkisfz1m	395	17	to	to	IN
cord-306948-wkisfz1m	395	18	the	the	DT
cord-306948-wkisfz1m	395	19	basic	basic	JJ
cord-306948-wkisfz1m	395	20	understanding	understanding	NN
cord-306948-wkisfz1m	395	21	of	of	IN
cord-306948-wkisfz1m	395	22	the	the	DT
cord-306948-wkisfz1m	395	23	biology	biology	NN
cord-306948-wkisfz1m	395	24	of	of	IN
cord-306948-wkisfz1m	395	25	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	395	26	and	and	CC
cord-306948-wkisfz1m	395	27	to	to	IN
cord-306948-wkisfz1m	395	28	the	the	DT
cord-306948-wkisfz1m	395	29	development	development	NN
cord-306948-wkisfz1m	395	30	of	of	IN
cord-306948-wkisfz1m	395	31	genetically	genetically	RB
cord-306948-wkisfz1m	395	32	modified	modify	VBN
cord-306948-wkisfz1m	395	33	vaccines	vaccine	NNS
cord-306948-wkisfz1m	395	34	and	and	CC
cord-306948-wkisfz1m	395	35	gene	gene	NN
cord-306948-wkisfz1m	395	36	delivery	delivery	NN
cord-306948-wkisfz1m	395	37	.	.	.
cord-306948-wkisfz1m	396	1	North	north	JJ
cord-306948-wkisfz1m	396	2	American	american	JJ
cord-306948-wkisfz1m	396	3	and	and	CC
cord-306948-wkisfz1m	396	4	European	european	JJ
cord-306948-wkisfz1m	396	5	porcine	porcine	JJ
cord-306948-wkisfz1m	396	6	reproductive	reproductive	JJ
cord-306948-wkisfz1m	396	7	and	and	CC
cord-306948-wkisfz1m	396	8	respiratory	respiratory	JJ
cord-306948-wkisfz1m	396	9	syndrome	syndrome	NN
cord-306948-wkisfz1m	396	10	viruses	virus	NNS
cord-306948-wkisfz1m	396	11	differ	differ	VBP
cord-306948-wkisfz1m	396	12	in	in	IN
cord-306948-wkisfz1m	396	13	non	non	JJ
cord-306948-wkisfz1m	396	14	-	-	JJ
cord-306948-wkisfz1m	396	15	structural	structural	JJ
cord-306948-wkisfz1m	396	16	protein	protein	NN
cord-306948-wkisfz1m	396	17	coding	code	VBG
cord-306948-wkisfz1m	396	18	regions	region	NNS
cord-306948-wkisfz1m	396	19	Engineering	engineer	VBG
cord-306948-wkisfz1m	396	20	the	the	DT
cord-306948-wkisfz1m	396	21	largest	large	JJS
cord-306948-wkisfz1m	396	22	RNA	RNA	NNP
cord-306948-wkisfz1m	396	23	virus	virus	NN
cord-306948-wkisfz1m	396	24	genome	genome	NN
cord-306948-wkisfz1m	396	25	as	as	IN
cord-306948-wkisfz1m	396	26	an	an	DT
cord-306948-wkisfz1m	396	27	infectious	infectious	JJ
cord-306948-wkisfz1m	396	28	bacterial	bacterial	JJ
cord-306948-wkisfz1m	396	29	artificial	artificial	JJ
cord-306948-wkisfz1m	396	30	chromosome	chromosome	NN
cord-306948-wkisfz1m	396	31	Influence	influence	NN
cord-306948-wkisfz1m	396	32	of	of	IN
cord-306948-wkisfz1m	396	33	Nlinked	Nlinked	NNP
cord-306948-wkisfz1m	396	34	glycosylation	glycosylation	NN
cord-306948-wkisfz1m	396	35	of	of	IN
cord-306948-wkisfz1m	396	36	porcine	porcine	JJ
cord-306948-wkisfz1m	396	37	reproductive	reproductive	JJ
cord-306948-wkisfz1m	396	38	and	and	CC
cord-306948-wkisfz1m	396	39	respiratory	respiratory	JJ
cord-306948-wkisfz1m	396	40	syndrome	syndrome	NN
cord-306948-wkisfz1m	396	41	virus	virus	NN
cord-306948-wkisfz1m	396	42	GP5	GP5	NNP
cord-306948-wkisfz1m	396	43	on	on	IN
cord-306948-wkisfz1m	396	44	virus	virus	NN
cord-306948-wkisfz1m	396	45	infectivity	infectivity	NN
cord-306948-wkisfz1m	396	46	,	,	,
cord-306948-wkisfz1m	396	47	antigenicity	antigenicity	NN
cord-306948-wkisfz1m	396	48	,	,	,
cord-306948-wkisfz1m	396	49	and	and	CC
cord-306948-wkisfz1m	396	50	ability	ability	NN
cord-306948-wkisfz1m	396	51	to	to	TO
cord-306948-wkisfz1m	396	52	induce	induce	VB
cord-306948-wkisfz1m	396	53	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	396	54	antibodies	antibody	NNS
cord-306948-wkisfz1m	396	55	Characterization	characterization	NN
cord-306948-wkisfz1m	396	56	of	of	IN
cord-306948-wkisfz1m	396	57	the	the	DT
cord-306948-wkisfz1m	396	58	neutralization	neutralization	NN
cord-306948-wkisfz1m	396	59	determinants	determinant	NNS
cord-306948-wkisfz1m	396	60	of	of	IN
cord-306948-wkisfz1m	396	61	equine	equine	JJ
cord-306948-wkisfz1m	396	62	arteritis	arteritis	NN
cord-306948-wkisfz1m	396	63	virus	virus	NN
cord-306948-wkisfz1m	396	64	using	use	VBG
cord-306948-wkisfz1m	396	65	recombinant	recombinant	JJ
cord-306948-wkisfz1m	396	66	chimeric	chimeric	JJ
cord-306948-wkisfz1m	396	67	viruses	virus	NNS
cord-306948-wkisfz1m	396	68	and	and	CC
cord-306948-wkisfz1m	396	69	site	site	NN
cord-306948-wkisfz1m	396	70	-	-	HYPH
cord-306948-wkisfz1m	396	71	specific	specific	JJ
cord-306948-wkisfz1m	396	72	mutagenesis	mutagenesis	NN
cord-306948-wkisfz1m	396	73	of	of	IN
cord-306948-wkisfz1m	396	74	an	an	DT
cord-306948-wkisfz1m	396	75	infectious	infectious	JJ
cord-306948-wkisfz1m	396	76	cDNA	cdna	NN
cord-306948-wkisfz1m	396	77	clone	clone	NN
cord-306948-wkisfz1m	396	78	Characterization	characterization	NN
cord-306948-wkisfz1m	396	79	of	of	IN
cord-306948-wkisfz1m	396	80	swine	swine	NN
cord-306948-wkisfz1m	396	81	infertility	infertility	NN
cord-306948-wkisfz1m	396	82	and	and	CC
cord-306948-wkisfz1m	396	83	respiratory	respiratory	JJ
cord-306948-wkisfz1m	396	84	syndrome	syndrome	NN
cord-306948-wkisfz1m	396	85	(	(	-LRB-
cord-306948-wkisfz1m	396	86	SIRS	SIRS	NNP
cord-306948-wkisfz1m	396	87	)	)	-RRB-
cord-306948-wkisfz1m	396	88	virus	virus	NN
cord-306948-wkisfz1m	396	89	(	(	-LRB-
cord-306948-wkisfz1m	396	90	Isolate	isolate	VB
cord-306948-wkisfz1m	396	91	ATCC	ATCC	NNP
cord-306948-wkisfz1m	396	92	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	396	93	)	)	-RRB-
cord-306948-wkisfz1m	397	1	Porcine	porcine	JJ
cord-306948-wkisfz1m	397	2	reproductive	reproductive	JJ
cord-306948-wkisfz1m	397	3	and	and	CC
cord-306948-wkisfz1m	397	4	respiratory	respiratory	JJ
cord-306948-wkisfz1m	397	5	syndrome	syndrome	NN
cord-306948-wkisfz1m	397	6	virus	virus	NN
cord-306948-wkisfz1m	397	7	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	397	8	protein	protein	NN
cord-306948-wkisfz1m	398	1	1beta	1beta	CD
cord-306948-wkisfz1m	398	2	modulates	modulate	VBZ
cord-306948-wkisfz1m	398	3	host	host	NN
cord-306948-wkisfz1m	398	4	innate	innate	JJ
cord-306948-wkisfz1m	398	5	immune	immune	JJ
cord-306948-wkisfz1m	398	6	response	response	NN
cord-306948-wkisfz1m	398	7	by	by	IN
cord-306948-wkisfz1m	398	8	antagonizing	antagonize	VBG
cord-306948-wkisfz1m	398	9	IRF3	IRF3	NNP
cord-306948-wkisfz1m	398	10	activation	activation	NN
cord-306948-wkisfz1m	398	11	Identification	identification	NN
cord-306948-wkisfz1m	398	12	of	of	IN
cord-306948-wkisfz1m	398	13	amino	amino	NN
cord-306948-wkisfz1m	398	14	acid	acid	NN
cord-306948-wkisfz1m	398	15	residues	residue	NNS
cord-306948-wkisfz1m	398	16	important	important	JJ
cord-306948-wkisfz1m	398	17	for	for	IN
cord-306948-wkisfz1m	398	18	anti	anti	JJ
cord-306948-wkisfz1m	398	19	-	-	JJ
cord-306948-wkisfz1m	398	20	IFN	IFN	NNP
cord-306948-wkisfz1m	398	21	activity	activity	NN
cord-306948-wkisfz1m	398	22	of	of	IN
cord-306948-wkisfz1m	398	23	porcine	porcine	JJ
cord-306948-wkisfz1m	398	24	reproductive	reproductive	JJ
cord-306948-wkisfz1m	398	25	and	and	CC
cord-306948-wkisfz1m	398	26	respiratory	respiratory	JJ
cord-306948-wkisfz1m	398	27	syndrome	syndrome	NN
cord-306948-wkisfz1m	398	28	virus	virus	NN
cord-306948-wkisfz1m	398	29	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	398	30	protein	protein	NN
cord-306948-wkisfz1m	398	31	1	1	CD
cord-306948-wkisfz1m	398	32	Infectious	infectious	JJ
cord-306948-wkisfz1m	398	33	transcripts	transcript	NNS
cord-306948-wkisfz1m	398	34	and	and	CC
cord-306948-wkisfz1m	398	35	cDNA	cdna	NN
cord-306948-wkisfz1m	398	36	clones	clone	NNS
cord-306948-wkisfz1m	398	37	of	of	IN
cord-306948-wkisfz1m	398	38	RNA	RNA	NNP
cord-306948-wkisfz1m	398	39	viruses	virus	NNS
cord-306948-wkisfz1m	398	40	Expression	expression	NN
cord-306948-wkisfz1m	398	41	of	of	IN
cord-306948-wkisfz1m	398	42	a	a	DT
cord-306948-wkisfz1m	398	43	foreign	foreign	JJ
cord-306948-wkisfz1m	398	44	epitope	epitope	NN
cord-306948-wkisfz1m	398	45	by	by	IN
cord-306948-wkisfz1m	398	46	porcine	porcine	JJ
cord-306948-wkisfz1m	398	47	reproductive	reproductive	JJ
cord-306948-wkisfz1m	398	48	and	and	CC
cord-306948-wkisfz1m	398	49	respiratory	respiratory	JJ
cord-306948-wkisfz1m	398	50	syndrome	syndrome	NN
cord-306948-wkisfz1m	398	51	virus	virus	NN
cord-306948-wkisfz1m	398	52	Pathogenesis	Pathogenesis	NNP
cord-306948-wkisfz1m	398	53	of	of	IN
cord-306948-wkisfz1m	398	54	porcine	porcine	JJ
cord-306948-wkisfz1m	398	55	reproductive	reproductive	JJ
cord-306948-wkisfz1m	398	56	and	and	CC
cord-306948-wkisfz1m	398	57	respiratory	respiratory	JJ
cord-306948-wkisfz1m	398	58	syndrome	syndrome	NN
cord-306948-wkisfz1m	398	59	virus	virus	NN
cord-306948-wkisfz1m	398	60	Identification	identification	NN
cord-306948-wkisfz1m	398	61	of	of	IN
cord-306948-wkisfz1m	398	62	two	two	CD
cord-306948-wkisfz1m	398	63	auto	auto	NN
cord-306948-wkisfz1m	398	64	-	-	HYPH
cord-306948-wkisfz1m	398	65	cleavage	cleavage	NN
cord-306948-wkisfz1m	398	66	products	product	NNS
cord-306948-wkisfz1m	398	67	of	of	IN
cord-306948-wkisfz1m	398	68	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	398	69	protein	protein	NNP
cord-306948-wkisfz1m	398	70	1	1	CD
cord-306948-wkisfz1m	398	71	(	(	-LRB-
cord-306948-wkisfz1m	398	72	nsp1	nsp1	NNS
cord-306948-wkisfz1m	398	73	)	)	-RRB-
cord-306948-wkisfz1m	398	74	in	in	IN
cord-306948-wkisfz1m	398	75	porcine	porcine	JJ
cord-306948-wkisfz1m	398	76	reproductive	reproductive	JJ
cord-306948-wkisfz1m	398	77	and	and	CC
cord-306948-wkisfz1m	398	78	respiratory	respiratory	JJ
cord-306948-wkisfz1m	398	79	syndrome	syndrome	NN
cord-306948-wkisfz1m	398	80	virus	virus	NN
cord-306948-wkisfz1m	398	81	infected	infect	VBN
cord-306948-wkisfz1m	398	82	cells	cell	NNS
cord-306948-wkisfz1m	398	83	:	:	:
cord-306948-wkisfz1m	399	1	nsp1	nsp1	NNS
cord-306948-wkisfz1m	399	2	function	function	VBP
cord-306948-wkisfz1m	399	3	as	as	IN
cord-306948-wkisfz1m	399	4	interferon	interferon	NN
cord-306948-wkisfz1m	399	5	antagonist	antagonist	NN
cord-306948-wkisfz1m	399	6	Immunodominant	Immunodominant	NNP
cord-306948-wkisfz1m	399	7	epitopes	epitope	NNS
cord-306948-wkisfz1m	399	8	in	in	IN
cord-306948-wkisfz1m	399	9	nsp2	nsp2	NN
cord-306948-wkisfz1m	399	10	of	of	IN
cord-306948-wkisfz1m	399	11	porcine	porcine	JJ
cord-306948-wkisfz1m	399	12	reproductive	reproductive	JJ
cord-306948-wkisfz1m	399	13	and	and	CC
cord-306948-wkisfz1m	399	14	respiratory	respiratory	JJ
cord-306948-wkisfz1m	399	15	syndrome	syndrome	NN
cord-306948-wkisfz1m	399	16	virus	virus	NN
cord-306948-wkisfz1m	399	17	are	be	VBP
cord-306948-wkisfz1m	399	18	dispensable	dispensable	JJ
cord-306948-wkisfz1m	399	19	for	for	IN
cord-306948-wkisfz1m	399	20	replication	replication	NN
cord-306948-wkisfz1m	399	21	,	,	,
cord-306948-wkisfz1m	399	22	but	but	CC
cord-306948-wkisfz1m	399	23	play	play	VB
cord-306948-wkisfz1m	399	24	an	an	DT
cord-306948-wkisfz1m	399	25	important	important	JJ
cord-306948-wkisfz1m	399	26	role	role	NN
cord-306948-wkisfz1m	399	27	in	in	IN
cord-306948-wkisfz1m	399	28	modulation	modulation	NN
cord-306948-wkisfz1m	399	29	of	of	IN
cord-306948-wkisfz1m	399	30	the	the	DT
cord-306948-wkisfz1m	399	31	host	host	NN
cord-306948-wkisfz1m	399	32	immune	immune	JJ
cord-306948-wkisfz1m	399	33	response	response	NN
cord-306948-wkisfz1m	400	1	Virus	virus	NN
cord-306948-wkisfz1m	400	2	attenuation	attenuation	NN
cord-306948-wkisfz1m	400	3	by	by	IN
cord-306948-wkisfz1m	400	4	genome	genome	NN
cord-306948-wkisfz1m	400	5	-	-	HYPH
cord-306948-wkisfz1m	400	6	scale	scale	NN
cord-306948-wkisfz1m	400	7	changes	change	NNS
cord-306948-wkisfz1m	400	8	in	in	IN
cord-306948-wkisfz1m	400	9	codon	codon	NN
cord-306948-wkisfz1m	400	10	pair	pair	NN
cord-306948-wkisfz1m	400	11	bias	bias	NN
cord-306948-wkisfz1m	400	12	Development	Development	NNP
cord-306948-wkisfz1m	400	13	of	of	IN
cord-306948-wkisfz1m	400	14	a	a	DT
cord-306948-wkisfz1m	400	15	porcine	porcine	JJ
cord-306948-wkisfz1m	400	16	reproductive	reproductive	JJ
cord-306948-wkisfz1m	400	17	and	and	CC
cord-306948-wkisfz1m	400	18	respiratory	respiratory	JJ
cord-306948-wkisfz1m	400	19	syndrome	syndrome	NN
cord-306948-wkisfz1m	400	20	virus	virus	NN
cord-306948-wkisfz1m	400	21	differentiable	differentiable	JJ
cord-306948-wkisfz1m	400	22	(	(	-LRB-
cord-306948-wkisfz1m	400	23	DIVA	diva	NN
cord-306948-wkisfz1m	400	24	)	)	-RRB-
cord-306948-wkisfz1m	400	25	strain	strain	VB
cord-306948-wkisfz1m	400	26	through	through	IN
cord-306948-wkisfz1m	400	27	deletion	deletion	NN
cord-306948-wkisfz1m	400	28	of	of	IN
cord-306948-wkisfz1m	400	29	specific	specific	JJ
cord-306948-wkisfz1m	400	30	immunodominant	immunodominant	JJ
cord-306948-wkisfz1m	400	31	epitopes	epitope	NNS
cord-306948-wkisfz1m	401	1	Serologic	serologic	NN
cord-306948-wkisfz1m	401	2	marker	marker	NN
cord-306948-wkisfz1m	401	3	candidates	candidate	NNS
cord-306948-wkisfz1m	401	4	identified	identify	VBN
cord-306948-wkisfz1m	401	5	among	among	IN
cord-306948-wkisfz1m	401	6	B	b	NN
cord-306948-wkisfz1m	401	7	-	-	HYPH
cord-306948-wkisfz1m	401	8	cell	cell	NN
cord-306948-wkisfz1m	401	9	linear	linear	JJ
cord-306948-wkisfz1m	401	10	epitopes	epitope	NNS
cord-306948-wkisfz1m	401	11	of	of	IN
cord-306948-wkisfz1m	401	12	Nsp2	Nsp2	NNP
cord-306948-wkisfz1m	401	13	and	and	CC
cord-306948-wkisfz1m	401	14	structural	structural	JJ
cord-306948-wkisfz1m	401	15	proteins	protein	NNS
cord-306948-wkisfz1m	401	16	of	of	IN
cord-306948-wkisfz1m	401	17	a	a	DT
cord-306948-wkisfz1m	401	18	North	north	JJ
cord-306948-wkisfz1m	401	19	American	american	JJ
cord-306948-wkisfz1m	401	20	strain	strain	NN
cord-306948-wkisfz1m	401	21	of	of	IN
cord-306948-wkisfz1m	401	22	porcine	porcine	JJ
cord-306948-wkisfz1m	401	23	reproductive	reproductive	JJ
cord-306948-wkisfz1m	401	24	and	and	CC
cord-306948-wkisfz1m	401	25	respiratory	respiratory	JJ
cord-306948-wkisfz1m	401	26	syndrome	syndrome	NN
cord-306948-wkisfz1m	401	27	virus	virus	NN
cord-306948-wkisfz1m	401	28	Genetic	genetic	JJ
cord-306948-wkisfz1m	401	29	manipulation	manipulation	NN
cord-306948-wkisfz1m	401	30	of	of	IN
cord-306948-wkisfz1m	401	31	equine	equine	JJ
cord-306948-wkisfz1m	401	32	arteritis	arteritis	NN
cord-306948-wkisfz1m	401	33	virus	virus	NN
cord-306948-wkisfz1m	401	34	using	use	VBG
cord-306948-wkisfz1m	401	35	full	full	JJ
cord-306948-wkisfz1m	401	36	-	-	HYPH
cord-306948-wkisfz1m	401	37	length	length	NN
cord-306948-wkisfz1m	401	38	cDNA	cdna	NN
cord-306948-wkisfz1m	401	39	clones	clone	NNS
cord-306948-wkisfz1m	401	40	:	:	:
cord-306948-wkisfz1m	401	41	separation	separation	NN
cord-306948-wkisfz1m	401	42	of	of	IN
cord-306948-wkisfz1m	401	43	overlapping	overlap	VBG
cord-306948-wkisfz1m	401	44	genes	gene	NNS
cord-306948-wkisfz1m	401	45	and	and	CC
cord-306948-wkisfz1m	401	46	expression	expression	NN
cord-306948-wkisfz1m	401	47	of	of	IN
cord-306948-wkisfz1m	401	48	a	a	DT
cord-306948-wkisfz1m	401	49	foreign	foreign	JJ
cord-306948-wkisfz1m	401	50	epitope	epitope	NN
cord-306948-wkisfz1m	401	51	Current	current	JJ
cord-306948-wkisfz1m	401	52	knowledge	knowledge	NN
cord-306948-wkisfz1m	401	53	on	on	IN
cord-306948-wkisfz1m	401	54	the	the	DT
cord-306948-wkisfz1m	401	55	structural	structural	JJ
cord-306948-wkisfz1m	401	56	proteins	protein	NNS
cord-306948-wkisfz1m	401	57	of	of	IN
cord-306948-wkisfz1m	401	58	porcine	porcine	JJ
cord-306948-wkisfz1m	401	59	reproductive	reproductive	JJ
cord-306948-wkisfz1m	401	60	and	and	CC
cord-306948-wkisfz1m	401	61	respiratory	respiratory	JJ
cord-306948-wkisfz1m	401	62	syndrome	syndrome	NN
cord-306948-wkisfz1m	401	63	(	(	-LRB-
cord-306948-wkisfz1m	401	64	PRRS	PRRS	NNP
cord-306948-wkisfz1m	401	65	)	)	-RRB-
cord-306948-wkisfz1m	401	66	virus	virus	NN
cord-306948-wkisfz1m	401	67	:	:	:
cord-306948-wkisfz1m	401	68	comparison	comparison	NN
cord-306948-wkisfz1m	401	69	of	of	IN
cord-306948-wkisfz1m	401	70	the	the	DT
cord-306948-wkisfz1m	401	71	North	north	JJ
cord-306948-wkisfz1m	401	72	American	american	JJ
cord-306948-wkisfz1m	401	73	and	and	CC
cord-306948-wkisfz1m	401	74	European	european	JJ
cord-306948-wkisfz1m	401	75	isolates	isolate	NNS
cord-306948-wkisfz1m	401	76	Equine	equine	JJ
cord-306948-wkisfz1m	401	77	arteritis	arteritis	NN
cord-306948-wkisfz1m	401	78	virus	virus	NN
cord-306948-wkisfz1m	401	79	is	be	VBZ
cord-306948-wkisfz1m	401	80	not	not	RB
cord-306948-wkisfz1m	401	81	a	a	DT
cord-306948-wkisfz1m	401	82	togavirus	togavirus	NN
cord-306948-wkisfz1m	401	83	but	but	CC
cord-306948-wkisfz1m	401	84	belongs	belong	VBZ
cord-306948-wkisfz1m	401	85	to	to	IN
cord-306948-wkisfz1m	401	86	the	the	DT
cord-306948-wkisfz1m	401	87	coronaviruslike	coronaviruslike	NNP
cord-306948-wkisfz1m	401	88	superfamily	superfamily	NNP
cord-306948-wkisfz1m	401	89	Structure	Structure	NNP
cord-306948-wkisfz1m	401	90	of	of	IN
cord-306948-wkisfz1m	401	91	the	the	DT
cord-306948-wkisfz1m	401	92	nucleocapsid	nucleocapsid	NNP
cord-306948-wkisfz1m	401	93	protein	protein	NN
cord-306948-wkisfz1m	401	94	of	of	IN
cord-306948-wkisfz1m	401	95	porcine	porcine	JJ
cord-306948-wkisfz1m	401	96	reproductive	reproductive	JJ
cord-306948-wkisfz1m	401	97	and	and	CC
cord-306948-wkisfz1m	401	98	respiratory	respiratory	JJ
cord-306948-wkisfz1m	401	99	syndrome	syndrome	NN
cord-306948-wkisfz1m	401	100	virus	virus	NN
cord-306948-wkisfz1m	401	101	Construction	Construction	NNP
cord-306948-wkisfz1m	401	102	of	of	IN
cord-306948-wkisfz1m	401	103	chimeric	chimeric	JJ
cord-306948-wkisfz1m	401	104	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	401	105	reveals	reveal	VBZ
cord-306948-wkisfz1m	401	106	that	that	IN
cord-306948-wkisfz1m	401	107	the	the	DT
cord-306948-wkisfz1m	401	108	ectodomain	ectodomain	NN
cord-306948-wkisfz1m	401	109	of	of	IN
cord-306948-wkisfz1m	401	110	the	the	DT
cord-306948-wkisfz1m	401	111	major	major	JJ
cord-306948-wkisfz1m	401	112	glycoprotein	glycoprotein	NN
cord-306948-wkisfz1m	401	113	is	be	VBZ
cord-306948-wkisfz1m	401	114	not	not	RB
cord-306948-wkisfz1m	401	115	the	the	DT
cord-306948-wkisfz1m	401	116	main	main	JJ
cord-306948-wkisfz1m	401	117	determinant	determinant	NN
cord-306948-wkisfz1m	401	118	of	of	IN
cord-306948-wkisfz1m	401	119	equine	equine	JJ
cord-306948-wkisfz1m	401	120	arteritis	arteritis	NN
cord-306948-wkisfz1m	401	121	virus	virus	NN
cord-306948-wkisfz1m	401	122	tropism	tropism	NN
cord-306948-wkisfz1m	401	123	in	in	IN
cord-306948-wkisfz1m	401	124	cell	cell	NN
cord-306948-wkisfz1m	401	125	culture	culture	NN
cord-306948-wkisfz1m	401	126	Development	development	NN
cord-306948-wkisfz1m	401	127	of	of	IN
cord-306948-wkisfz1m	401	128	genetic	genetic	JJ
cord-306948-wkisfz1m	401	129	markers	marker	NNS
cord-306948-wkisfz1m	401	130	in	in	IN
cord-306948-wkisfz1m	401	131	the	the	DT
cord-306948-wkisfz1m	401	132	non	non	JJ
cord-306948-wkisfz1m	401	133	-	-	JJ
cord-306948-wkisfz1m	401	134	structural	structural	JJ
cord-306948-wkisfz1m	401	135	protein	protein	NN
cord-306948-wkisfz1m	401	136	2	2	CD
cord-306948-wkisfz1m	401	137	region	region	NN
cord-306948-wkisfz1m	401	138	of	of	IN
cord-306948-wkisfz1m	401	139	a	a	DT
cord-306948-wkisfz1m	401	140	US	US	NNP
cord-306948-wkisfz1m	401	141	type	type	NN
cord-306948-wkisfz1m	401	142	1	1	CD
cord-306948-wkisfz1m	401	143	porcine	porcine	JJ
cord-306948-wkisfz1m	401	144	reproductive	reproductive	JJ
cord-306948-wkisfz1m	401	145	and	and	CC
cord-306948-wkisfz1m	401	146	respiratory	respiratory	JJ
cord-306948-wkisfz1m	401	147	syndrome	syndrome	NN
cord-306948-wkisfz1m	401	148	virus	virus	NN
cord-306948-wkisfz1m	401	149	:	:	:
cord-306948-wkisfz1m	401	150	implications	implication	NNS
cord-306948-wkisfz1m	401	151	for	for	IN
cord-306948-wkisfz1m	401	152	future	future	JJ
cord-306948-wkisfz1m	401	153	recombinant	recombinant	JJ
cord-306948-wkisfz1m	401	154	marker	marker	NN
cord-306948-wkisfz1m	401	155	vaccine	vaccine	NN
cord-306948-wkisfz1m	401	156	development	development	NN
cord-306948-wkisfz1m	401	157	Construction	Construction	NNP
cord-306948-wkisfz1m	401	158	of	of	IN
cord-306948-wkisfz1m	401	159	a	a	DT
cord-306948-wkisfz1m	401	160	full	full	JJ
cord-306948-wkisfz1m	401	161	-	-	HYPH
cord-306948-wkisfz1m	401	162	length	length	NN
cord-306948-wkisfz1m	401	163	cDNA	cdna	NN
cord-306948-wkisfz1m	401	164	infectious	infectious	JJ
cord-306948-wkisfz1m	401	165	clone	clone	NN
cord-306948-wkisfz1m	401	166	of	of	IN
cord-306948-wkisfz1m	401	167	a	a	DT
cord-306948-wkisfz1m	401	168	European	european	JJ
cord-306948-wkisfz1m	401	169	-	-	HYPH
cord-306948-wkisfz1m	401	170	like	like	JJ
cord-306948-wkisfz1m	401	171	type	type	NN
cord-306948-wkisfz1m	401	172	1	1	CD
cord-306948-wkisfz1m	401	173	PRRSV	PRRSV	NNS
cord-306948-wkisfz1m	401	174	isolated	isolate	VBN
cord-306948-wkisfz1m	401	175	in	in	IN
cord-306948-wkisfz1m	401	176	the	the	DT
cord-306948-wkisfz1m	401	177	US	US	NNP
cord-306948-wkisfz1m	401	178	Heterogeneity	Heterogeneity	NNP
cord-306948-wkisfz1m	401	179	in	in	IN
cord-306948-wkisfz1m	401	180	Nsp2	Nsp2	NNP
cord-306948-wkisfz1m	401	181	of	of	IN
cord-306948-wkisfz1m	401	182	European	european	JJ
cord-306948-wkisfz1m	401	183	-	-	HYPH
cord-306948-wkisfz1m	401	184	like	like	JJ
cord-306948-wkisfz1m	401	185	porcine	porcine	JJ
cord-306948-wkisfz1m	401	186	reproductive	reproductive	JJ
cord-306948-wkisfz1m	401	187	and	and	CC
cord-306948-wkisfz1m	401	188	respiratory	respiratory	JJ
cord-306948-wkisfz1m	401	189	syndrome	syndrome	NN
cord-306948-wkisfz1m	401	190	viruses	virus	NNS
cord-306948-wkisfz1m	401	191	isolated	isolate	VBN
cord-306948-wkisfz1m	401	192	in	in	IN
cord-306948-wkisfz1m	401	193	the	the	DT
cord-306948-wkisfz1m	401	194	United	United	NNP
cord-306948-wkisfz1m	401	195	States	States	NNP
cord-306948-wkisfz1m	401	196	A	a	DT
cord-306948-wkisfz1m	401	197	full	full	JJ
cord-306948-wkisfz1m	401	198	-	-	HYPH
cord-306948-wkisfz1m	401	199	length	length	NN
cord-306948-wkisfz1m	401	200	cDNA	cdna	NN
cord-306948-wkisfz1m	401	201	infectious	infectious	JJ
cord-306948-wkisfz1m	401	202	clone	clone	NN
cord-306948-wkisfz1m	401	203	of	of	IN
cord-306948-wkisfz1m	401	204	North	north	JJ
cord-306948-wkisfz1m	401	205	American	american	JJ
cord-306948-wkisfz1m	401	206	type	type	NN
cord-306948-wkisfz1m	401	207	1	1	CD
cord-306948-wkisfz1m	401	208	porcine	porcine	JJ
cord-306948-wkisfz1m	401	209	reproductive	reproductive	JJ
cord-306948-wkisfz1m	401	210	and	and	CC
cord-306948-wkisfz1m	401	211	respiratory	respiratory	JJ
cord-306948-wkisfz1m	401	212	syndrome	syndrome	NN
cord-306948-wkisfz1m	401	213	virus	virus	NN
cord-306948-wkisfz1m	401	214	:	:	:
cord-306948-wkisfz1m	401	215	expression	expression	NN
cord-306948-wkisfz1m	401	216	of	of	IN
cord-306948-wkisfz1m	401	217	green	green	JJ
cord-306948-wkisfz1m	401	218	fluorescent	fluorescent	NN
cord-306948-wkisfz1m	401	219	protein	protein	NN
cord-306948-wkisfz1m	401	220	in	in	IN
cord-306948-wkisfz1m	401	221	the	the	DT
cord-306948-wkisfz1m	401	222	Nsp2	Nsp2	NNP
cord-306948-wkisfz1m	401	223	region	region	NN
cord-306948-wkisfz1m	402	1	The	the	DT
cord-306948-wkisfz1m	402	2	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	402	3	replicase	replicase	NN
cord-306948-wkisfz1m	402	4	:	:	:
cord-306948-wkisfz1m	402	5	exploring	explore	VBG
cord-306948-wkisfz1m	402	6	the	the	DT
cord-306948-wkisfz1m	402	7	multifunctionality	multifunctionality	NN
cord-306948-wkisfz1m	402	8	of	of	IN
cord-306948-wkisfz1m	402	9	an	an	DT
cord-306948-wkisfz1m	402	10	intriguing	intriguing	JJ
cord-306948-wkisfz1m	402	11	set	set	NN
cord-306948-wkisfz1m	402	12	of	of	IN
cord-306948-wkisfz1m	402	13	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	402	14	proteins	protein	NNS
cord-306948-wkisfz1m	402	15	Efficient-2	Efficient-2	NNP
cord-306948-wkisfz1m	402	16	frameshifting	frameshifte	VBG
cord-306948-wkisfz1m	402	17	by	by	IN
cord-306948-wkisfz1m	402	18	mammalian	mammalian	JJ
cord-306948-wkisfz1m	402	19	ribosomes	ribosome	NNS
cord-306948-wkisfz1m	402	20	to	to	TO
cord-306948-wkisfz1m	402	21	synthesize	synthesize	VB
cord-306948-wkisfz1m	402	22	an	an	DT
cord-306948-wkisfz1m	402	23	additional	additional	JJ
cord-306948-wkisfz1m	402	24	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	402	25	protein	protein	NN
cord-306948-wkisfz1m	402	26	Discovery	Discovery	NNP
cord-306948-wkisfz1m	402	27	of	of	IN
cord-306948-wkisfz1m	402	28	a	a	DT
cord-306948-wkisfz1m	402	29	small	small	JJ
cord-306948-wkisfz1m	402	30	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	402	31	gene	gene	NN
cord-306948-wkisfz1m	402	32	that	that	WDT
cord-306948-wkisfz1m	402	33	overlaps	overlap	VBZ
cord-306948-wkisfz1m	402	34	the	the	DT
cord-306948-wkisfz1m	402	35	GP5	GP5	NNP
cord-306948-wkisfz1m	402	36	coding	code	VBG
cord-306948-wkisfz1m	402	37	sequence	sequence	NN
cord-306948-wkisfz1m	402	38	and	and	CC
cord-306948-wkisfz1m	402	39	is	be	VBZ
cord-306948-wkisfz1m	402	40	important	important	JJ
cord-306948-wkisfz1m	402	41	for	for	IN
cord-306948-wkisfz1m	402	42	virus	virus	NN
cord-306948-wkisfz1m	402	43	production	production	NN
cord-306948-wkisfz1m	402	44	Ovarian	ovarian	JJ
cord-306948-wkisfz1m	402	45	tumor	tumor	NN
cord-306948-wkisfz1m	402	46	domain	domain	NN
cord-306948-wkisfz1m	402	47	-	-	HYPH
cord-306948-wkisfz1m	402	48	containing	contain	VBG
cord-306948-wkisfz1m	402	49	viral	viral	JJ
cord-306948-wkisfz1m	402	50	proteases	protease	NNS
cord-306948-wkisfz1m	402	51	evade	evade	VBP
cord-306948-wkisfz1m	402	52	ubiquitin	ubiquitin	NN
cord-306948-wkisfz1m	402	53	-	-	:
cord-306948-wkisfz1m	402	54	and	and	CC
cord-306948-wkisfz1m	402	55	ISG15-dependent	isg15-dependent	CD
cord-306948-wkisfz1m	402	56	innate	innate	JJ
cord-306948-wkisfz1m	402	57	immune	immune	JJ
cord-306948-wkisfz1m	402	58	responses	response	NNS
cord-306948-wkisfz1m	402	59	Cis	Cis	NNP
cord-306948-wkisfz1m	402	60	-	-	HYPH
cord-306948-wkisfz1m	402	61	acting	act	VBG
cord-306948-wkisfz1m	402	62	structural	structural	JJ
cord-306948-wkisfz1m	402	63	element	element	NN
cord-306948-wkisfz1m	402	64	in	in	IN
cord-306948-wkisfz1m	402	65	5	5	CD
cord-306948-wkisfz1m	402	66	0	0	CD
cord-306948-wkisfz1m	403	1	UTR	UTR	NNP
cord-306948-wkisfz1m	403	2	is	be	VBZ
cord-306948-wkisfz1m	403	3	essential	essential	JJ
cord-306948-wkisfz1m	403	4	for	for	IN
cord-306948-wkisfz1m	403	5	infectivity	infectivity	NN
cord-306948-wkisfz1m	403	6	of	of	IN
cord-306948-wkisfz1m	403	7	porcine	porcine	JJ
cord-306948-wkisfz1m	403	8	reproductive	reproductive	JJ
cord-306948-wkisfz1m	403	9	and	and	CC
cord-306948-wkisfz1m	403	10	respiratory	respiratory	JJ
cord-306948-wkisfz1m	403	11	syndrome	syndrome	NN
cord-306948-wkisfz1m	403	12	virus	virus	NN
cord-306948-wkisfz1m	403	13	Replacement	replacement	NN
cord-306948-wkisfz1m	403	14	of	of	IN
cord-306948-wkisfz1m	403	15	the	the	DT
cord-306948-wkisfz1m	403	16	heterologous	heterologous	JJ
cord-306948-wkisfz1m	403	17	5	5	CD
cord-306948-wkisfz1m	403	18	0	0	CD
cord-306948-wkisfz1m	403	19	untranslated	untranslated	JJ
cord-306948-wkisfz1m	403	20	region	region	NN
cord-306948-wkisfz1m	403	21	allows	allow	VBZ
cord-306948-wkisfz1m	403	22	preservation	preservation	NN
cord-306948-wkisfz1m	403	23	of	of	IN
cord-306948-wkisfz1m	403	24	the	the	DT
cord-306948-wkisfz1m	403	25	fully	fully	RB
cord-306948-wkisfz1m	403	26	functional	functional	JJ
cord-306948-wkisfz1m	403	27	activities	activity	NNS
cord-306948-wkisfz1m	403	28	of	of	IN
cord-306948-wkisfz1m	403	29	type	type	NN
cord-306948-wkisfz1m	403	30	2	2	CD
cord-306948-wkisfz1m	403	31	porcine	porcine	JJ
cord-306948-wkisfz1m	403	32	reproductive	reproductive	JJ
cord-306948-wkisfz1m	403	33	and	and	CC
cord-306948-wkisfz1m	403	34	respiratory	respiratory	JJ
cord-306948-wkisfz1m	403	35	syndrome	syndrome	NN
cord-306948-wkisfz1m	403	36	virus	virus	NN
cord-306948-wkisfz1m	403	37	Genomic	genomic	JJ
cord-306948-wkisfz1m	403	38	characterization	characterization	NN
cord-306948-wkisfz1m	403	39	of	of	IN
cord-306948-wkisfz1m	403	40	two	two	CD
cord-306948-wkisfz1m	403	41	Chinese	chinese	JJ
cord-306948-wkisfz1m	403	42	isolates	isolate	NNS
cord-306948-wkisfz1m	403	43	of	of	IN
cord-306948-wkisfz1m	403	44	porcine	porcine	JJ
cord-306948-wkisfz1m	403	45	respiratory	respiratory	JJ
cord-306948-wkisfz1m	403	46	and	and	CC
cord-306948-wkisfz1m	403	47	reproductive	reproductive	JJ
cord-306948-wkisfz1m	403	48	syndrome	syndrome	NN
cord-306948-wkisfz1m	403	49	virus	virus	NN
cord-306948-wkisfz1m	403	50	Experimental	experimental	JJ
cord-306948-wkisfz1m	403	51	infection	infection	NN
cord-306948-wkisfz1m	403	52	of	of	IN
cord-306948-wkisfz1m	403	53	United	United	NNP
cord-306948-wkisfz1m	403	54	States	States	NNP
cord-306948-wkisfz1m	403	55	swine	swine	NN
cord-306948-wkisfz1m	403	56	with	with	IN
cord-306948-wkisfz1m	403	57	a	a	DT
cord-306948-wkisfz1m	403	58	Chinese	Chinese	NNP
cord-306948-wkisfz1m	403	59	highly	highly	RB
cord-306948-wkisfz1m	403	60	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	403	61	strain	strain	NN
cord-306948-wkisfz1m	403	62	of	of	IN
cord-306948-wkisfz1m	403	63	porcine	porcine	JJ
cord-306948-wkisfz1m	403	64	reproductive	reproductive	JJ
cord-306948-wkisfz1m	403	65	and	and	CC
cord-306948-wkisfz1m	403	66	respiratory	respiratory	JJ
cord-306948-wkisfz1m	403	67	syndrome	syndrome	NN
cord-306948-wkisfz1m	403	68	virus	virus	NN
cord-306948-wkisfz1m	403	69	Identification	identification	NN
cord-306948-wkisfz1m	403	70	of	of	IN
cord-306948-wkisfz1m	403	71	nonessential	nonessential	JJ
cord-306948-wkisfz1m	403	72	regions	region	NNS
cord-306948-wkisfz1m	403	73	of	of	IN
cord-306948-wkisfz1m	403	74	the	the	DT
cord-306948-wkisfz1m	403	75	nsp2	nsp2	NNP
cord-306948-wkisfz1m	403	76	replicase	replicase	NNP
cord-306948-wkisfz1m	403	77	protein	protein	NN
cord-306948-wkisfz1m	403	78	of	of	IN
cord-306948-wkisfz1m	403	79	porcine	porcine	JJ
cord-306948-wkisfz1m	403	80	reproductive	reproductive	JJ
cord-306948-wkisfz1m	403	81	and	and	CC
cord-306948-wkisfz1m	403	82	respiratory	respiratory	JJ
cord-306948-wkisfz1m	403	83	syndrome	syndrome	NN
cord-306948-wkisfz1m	403	84	virus	virus	NN
cord-306948-wkisfz1m	403	85	strain	strain	NN
cord-306948-wkisfz1m	403	86	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	403	87	for	for	IN
cord-306948-wkisfz1m	403	88	replication	replication	NN
cord-306948-wkisfz1m	403	89	in	in	IN
cord-306948-wkisfz1m	403	90	cell	cell	NN
cord-306948-wkisfz1m	403	91	culture	culture	NN
cord-306948-wkisfz1m	404	1	The	the	DT
cord-306948-wkisfz1m	404	2	porcine	porcine	JJ
cord-306948-wkisfz1m	404	3	reproductive	reproductive	JJ
cord-306948-wkisfz1m	404	4	and	and	CC
cord-306948-wkisfz1m	404	5	respiratory	respiratory	JJ
cord-306948-wkisfz1m	404	6	syndrome	syndrome	NN
cord-306948-wkisfz1m	404	7	virus	virus	NN
cord-306948-wkisfz1m	405	1	nsp2	nsp2	NNP
cord-306948-wkisfz1m	405	2	cysteine	cysteine	NN
cord-306948-wkisfz1m	405	3	protease	protease	NN
cord-306948-wkisfz1m	405	4	domain	domain	NN
cord-306948-wkisfz1m	405	5	possesses	possess	VBZ
cord-306948-wkisfz1m	405	6	both	both	DT
cord-306948-wkisfz1m	405	7	trans	trans	NNP
cord-306948-wkisfz1m	405	8	-	-	HYPH
cord-306948-wkisfz1m	405	9	and	and	CC
cord-306948-wkisfz1m	405	10	cis	cis	NNP
cord-306948-wkisfz1m	405	11	-	-	HYPH
cord-306948-wkisfz1m	405	12	cleavage	cleavage	NN
cord-306948-wkisfz1m	405	13	activities	activity	NNS
cord-306948-wkisfz1m	406	1	Complete	complete	JJ
cord-306948-wkisfz1m	406	2	genome	genome	NN
cord-306948-wkisfz1m	406	3	analysis	analysis	NN
cord-306948-wkisfz1m	406	4	of	of	IN
cord-306948-wkisfz1m	406	5	RFLP	RFLP	NNP
cord-306948-wkisfz1m	406	6	184	184	CD
cord-306948-wkisfz1m	406	7	isolates	isolate	NNS
cord-306948-wkisfz1m	406	8	of	of	IN
cord-306948-wkisfz1m	406	9	porcine	porcine	JJ
cord-306948-wkisfz1m	406	10	reproductive	reproductive	JJ
cord-306948-wkisfz1m	406	11	and	and	CC
cord-306948-wkisfz1m	406	12	respiratory	respiratory	JJ
cord-306948-wkisfz1m	406	13	syndrome	syndrome	NN
cord-306948-wkisfz1m	406	14	virus	virus	NN
cord-306948-wkisfz1m	406	15	Degradation	degradation	NN
cord-306948-wkisfz1m	406	16	of	of	IN
cord-306948-wkisfz1m	406	17	CREB	CREB	NNP
cord-306948-wkisfz1m	406	18	-	-	HYPH
cord-306948-wkisfz1m	406	19	binding	bind	VBG
cord-306948-wkisfz1m	406	20	protein	protein	NN
cord-306948-wkisfz1m	406	21	and	and	CC
cord-306948-wkisfz1m	406	22	modulation	modulation	NN
cord-306948-wkisfz1m	406	23	of	of	IN
cord-306948-wkisfz1m	406	24	type	type	NN
cord-306948-wkisfz1m	407	1	I	-PRON-	PRP
cord-306948-wkisfz1m	407	2	interferon	interferon	VBD
cord-306948-wkisfz1m	407	3	induction	induction	NN
cord-306948-wkisfz1m	407	4	by	by	IN
cord-306948-wkisfz1m	407	5	the	the	DT
cord-306948-wkisfz1m	407	6	zinc	zinc	NN
cord-306948-wkisfz1m	407	7	finger	finger	NN
cord-306948-wkisfz1m	407	8	motif	motif	NN
cord-306948-wkisfz1m	407	9	of	of	IN
cord-306948-wkisfz1m	407	10	the	the	DT
cord-306948-wkisfz1m	407	11	porcine	porcine	JJ
cord-306948-wkisfz1m	407	12	reproductive	reproductive	JJ
cord-306948-wkisfz1m	407	13	and	and	CC
cord-306948-wkisfz1m	407	14	respiratory	respiratory	JJ
cord-306948-wkisfz1m	407	15	syndrome	syndrome	NN
cord-306948-wkisfz1m	407	16	virus	virus	NN
cord-306948-wkisfz1m	407	17	nsp1	nsp1	CD
cord-306948-wkisfz1m	407	18	alpha	alpha	NN
cord-306948-wkisfz1m	407	19	subunit	subunit	NN
cord-306948-wkisfz1m	407	20	Novel	Novel	NNP
cord-306948-wkisfz1m	407	21	structural	structural	JJ
cord-306948-wkisfz1m	407	22	protein	protein	NN
cord-306948-wkisfz1m	407	23	in	in	IN
cord-306948-wkisfz1m	407	24	porcine	porcine	JJ
cord-306948-wkisfz1m	407	25	reproductive	reproductive	JJ
cord-306948-wkisfz1m	407	26	and	and	CC
cord-306948-wkisfz1m	407	27	respiratory	respiratory	JJ
cord-306948-wkisfz1m	407	28	syndrome	syndrome	NN
cord-306948-wkisfz1m	407	29	virus	virus	NN
cord-306948-wkisfz1m	407	30	encoded	encode	VBN
cord-306948-wkisfz1m	407	31	by	by	IN
cord-306948-wkisfz1m	407	32	an	an	DT
cord-306948-wkisfz1m	407	33	alternative	alternative	JJ
cord-306948-wkisfz1m	407	34	ORF5	orf5	NN
cord-306948-wkisfz1m	407	35	present	present	NN
cord-306948-wkisfz1m	407	36	in	in	IN
cord-306948-wkisfz1m	407	37	all	all	DT
cord-306948-wkisfz1m	407	38	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	408	1	Genetic	genetic	JJ
cord-306948-wkisfz1m	408	2	variation	variation	NN
cord-306948-wkisfz1m	408	3	in	in	IN
cord-306948-wkisfz1m	408	4	porcine	porcine	JJ
cord-306948-wkisfz1m	408	5	reproductive	reproductive	JJ
cord-306948-wkisfz1m	408	6	and	and	CC
cord-306948-wkisfz1m	408	7	respiratory	respiratory	JJ
cord-306948-wkisfz1m	408	8	syndrome	syndrome	NN
cord-306948-wkisfz1m	408	9	virus	virus	NN
cord-306948-wkisfz1m	408	10	isolates	isolate	VBZ
cord-306948-wkisfz1m	408	11	in	in	IN
cord-306948-wkisfz1m	408	12	the	the	DT
cord-306948-wkisfz1m	408	13	midwestern	midwestern	JJ
cord-306948-wkisfz1m	408	14	United	United	NNP
cord-306948-wkisfz1m	408	15	States	States	NNP
cord-306948-wkisfz1m	408	16	Expression	Expression	NNP
cord-306948-wkisfz1m	408	17	and	and	CC
cord-306948-wkisfz1m	408	18	stability	stability	NN
cord-306948-wkisfz1m	408	19	of	of	IN
cord-306948-wkisfz1m	408	20	foreign	foreign	JJ
cord-306948-wkisfz1m	408	21	tags	tag	NNS
cord-306948-wkisfz1m	408	22	inserted	insert	VBN
cord-306948-wkisfz1m	408	23	into	into	IN
cord-306948-wkisfz1m	408	24	nsp2	nsp2	NN
cord-306948-wkisfz1m	408	25	of	of	IN
cord-306948-wkisfz1m	408	26	porcine	porcine	JJ
cord-306948-wkisfz1m	408	27	reproductive	reproductive	JJ
cord-306948-wkisfz1m	408	28	and	and	CC
cord-306948-wkisfz1m	408	29	respiratory	respiratory	JJ
cord-306948-wkisfz1m	408	30	syndrome	syndrome	NN
cord-306948-wkisfz1m	408	31	virus	virus	NN
cord-306948-wkisfz1m	408	32	Modulation	modulation	NN
cord-306948-wkisfz1m	408	33	of	of	IN
cord-306948-wkisfz1m	408	34	type	type	NN
cord-306948-wkisfz1m	409	1	I	-PRON-	PRP
cord-306948-wkisfz1m	409	2	interferon	interferon	VBD
cord-306948-wkisfz1m	409	3	induction	induction	NN
cord-306948-wkisfz1m	409	4	by	by	IN
cord-306948-wkisfz1m	409	5	porcine	porcine	JJ
cord-306948-wkisfz1m	409	6	reproductive	reproductive	JJ
cord-306948-wkisfz1m	409	7	and	and	CC
cord-306948-wkisfz1m	409	8	respiratory	respiratory	JJ
cord-306948-wkisfz1m	409	9	syndrome	syndrome	NN
cord-306948-wkisfz1m	409	10	virus	virus	NN
cord-306948-wkisfz1m	409	11	and	and	CC
cord-306948-wkisfz1m	409	12	degradation	degradation	NN
cord-306948-wkisfz1m	409	13	of	of	IN
cord-306948-wkisfz1m	409	14	CREB	CREB	NNP
cord-306948-wkisfz1m	409	15	-	-	HYPH
cord-306948-wkisfz1m	409	16	binding	bind	VBG
cord-306948-wkisfz1m	409	17	protein	protein	NN
cord-306948-wkisfz1m	409	18	by	by	IN
cord-306948-wkisfz1m	409	19	non	non	JJ
cord-306948-wkisfz1m	409	20	-	-	JJ
cord-306948-wkisfz1m	409	21	structural	structural	JJ
cord-306948-wkisfz1m	409	22	protein	protein	NN
cord-306948-wkisfz1m	409	23	1	1	CD
cord-306948-wkisfz1m	409	24	in	in	IN
cord-306948-wkisfz1m	409	25	MARC-145	MARC-145	NNP
cord-306948-wkisfz1m	409	26	and	and	CC
cord-306948-wkisfz1m	409	27	HeLa	HeLa	NNP
cord-306948-wkisfz1m	409	28	cells	cell	NNS
cord-306948-wkisfz1m	409	29	Molecular	molecular	JJ
cord-306948-wkisfz1m	409	30	assessment	assessment	NN
cord-306948-wkisfz1m	409	31	of	of	IN
cord-306948-wkisfz1m	409	32	the	the	DT
cord-306948-wkisfz1m	409	33	role	role	NN
cord-306948-wkisfz1m	409	34	of	of	IN
cord-306948-wkisfz1m	409	35	envelopeassociated	envelopeassociated	JJ
cord-306948-wkisfz1m	409	36	structural	structural	JJ
cord-306948-wkisfz1m	409	37	proteins	protein	NNS
cord-306948-wkisfz1m	409	38	in	in	IN
cord-306948-wkisfz1m	409	39	cross	cross	NN
cord-306948-wkisfz1m	409	40	neutralization	neutralization	NN
cord-306948-wkisfz1m	409	41	among	among	IN
cord-306948-wkisfz1m	409	42	different	different	JJ
cord-306948-wkisfz1m	409	43	PRRS	PRRS	NNP
cord-306948-wkisfz1m	409	44	viruses	virus	NNS
cord-306948-wkisfz1m	410	1	The	the	DT
cord-306948-wkisfz1m	410	2	nsp1	nsp1	NNPS
cord-306948-wkisfz1m	410	3	alpha	alpha	NN
cord-306948-wkisfz1m	410	4	and	and	CC
cord-306948-wkisfz1m	410	5	nsp1	nsp1	NNS
cord-306948-wkisfz1m	410	6	beta	beta	NN
cord-306948-wkisfz1m	410	7	papain	papain	NN
cord-306948-wkisfz1m	410	8	-	-	HYPH
cord-306948-wkisfz1m	410	9	like	like	JJ
cord-306948-wkisfz1m	410	10	autoproteinases	autoproteinase	NNS
cord-306948-wkisfz1m	410	11	are	be	VBP
cord-306948-wkisfz1m	410	12	essential	essential	JJ
cord-306948-wkisfz1m	410	13	for	for	IN
cord-306948-wkisfz1m	410	14	porcine	porcine	JJ
cord-306948-wkisfz1m	410	15	reproductive	reproductive	JJ
cord-306948-wkisfz1m	410	16	and	and	CC
cord-306948-wkisfz1m	410	17	respiratory	respiratory	JJ
cord-306948-wkisfz1m	410	18	syndrome	syndrome	NN
cord-306948-wkisfz1m	410	19	virus	virus	NN
cord-306948-wkisfz1m	410	20	RNA	RNA	NNP
cord-306948-wkisfz1m	410	21	synthesis	synthesis	NN
cord-306948-wkisfz1m	410	22	Infectious	infectious	JJ
cord-306948-wkisfz1m	410	23	clonederived	clonederive	VBN
cord-306948-wkisfz1m	410	24	viruses	virus	NNS
cord-306948-wkisfz1m	410	25	from	from	IN
cord-306948-wkisfz1m	410	26	virulent	virulent	JJ
cord-306948-wkisfz1m	410	27	and	and	CC
cord-306948-wkisfz1m	410	28	vaccine	vaccine	NN
cord-306948-wkisfz1m	410	29	strains	strain	NNS
cord-306948-wkisfz1m	410	30	of	of	IN
cord-306948-wkisfz1m	410	31	porcine	porcine	JJ
cord-306948-wkisfz1m	410	32	reproductive	reproductive	JJ
cord-306948-wkisfz1m	410	33	and	and	CC
cord-306948-wkisfz1m	410	34	respiratory	respiratory	JJ
cord-306948-wkisfz1m	410	35	syndrome	syndrome	NN
cord-306948-wkisfz1m	410	36	virus	virus	NN
cord-306948-wkisfz1m	410	37	mimic	mimic	VBP
cord-306948-wkisfz1m	410	38	biological	biological	JJ
cord-306948-wkisfz1m	410	39	properties	property	NNS
cord-306948-wkisfz1m	410	40	of	of	IN
cord-306948-wkisfz1m	410	41	their	-PRON-	PRP$
cord-306948-wkisfz1m	410	42	parental	parental	JJ
cord-306948-wkisfz1m	410	43	viruses	virus	NNS
cord-306948-wkisfz1m	410	44	in	in	IN
cord-306948-wkisfz1m	410	45	a	a	DT
cord-306948-wkisfz1m	410	46	pregnant	pregnant	JJ
cord-306948-wkisfz1m	410	47	sow	sow	NN
cord-306948-wkisfz1m	410	48	model	model	NN
cord-306948-wkisfz1m	410	49	Identification	identification	NN
cord-306948-wkisfz1m	410	50	of	of	IN
cord-306948-wkisfz1m	410	51	virulence	virulence	NN
cord-306948-wkisfz1m	410	52	determinants	determinant	NNS
cord-306948-wkisfz1m	410	53	of	of	IN
cord-306948-wkisfz1m	410	54	porcine	porcine	JJ
cord-306948-wkisfz1m	410	55	reproductive	reproductive	JJ
cord-306948-wkisfz1m	410	56	and	and	CC
cord-306948-wkisfz1m	410	57	respiratory	respiratory	JJ
cord-306948-wkisfz1m	410	58	syndrome	syndrome	NN
cord-306948-wkisfz1m	410	59	virus	virus	NN
cord-306948-wkisfz1m	410	60	through	through	IN
cord-306948-wkisfz1m	410	61	construction	construction	NN
cord-306948-wkisfz1m	410	62	of	of	IN
cord-306948-wkisfz1m	410	63	chimeric	chimeric	JJ
cord-306948-wkisfz1m	410	64	clones	clone	NNS
cord-306948-wkisfz1m	410	65	A	a	DT
cord-306948-wkisfz1m	410	66	DNA	dna	NN
cord-306948-wkisfz1m	410	67	-	-	HYPH
cord-306948-wkisfz1m	410	68	launched	launch	VBN
cord-306948-wkisfz1m	410	69	reverse	reverse	NN
cord-306948-wkisfz1m	410	70	genetics	genetics	NN
cord-306948-wkisfz1m	410	71	system	system	NN
cord-306948-wkisfz1m	410	72	for	for	IN
cord-306948-wkisfz1m	410	73	porcine	porcine	JJ
cord-306948-wkisfz1m	410	74	reproductive	reproductive	JJ
cord-306948-wkisfz1m	410	75	and	and	CC
cord-306948-wkisfz1m	410	76	respiratory	respiratory	JJ
cord-306948-wkisfz1m	410	77	syndrome	syndrome	NN
cord-306948-wkisfz1m	410	78	virus	virus	NN
cord-306948-wkisfz1m	410	79	reveals	reveal	VBZ
cord-306948-wkisfz1m	410	80	that	that	IN
cord-306948-wkisfz1m	410	81	homodimerization	homodimerization	NN
cord-306948-wkisfz1m	410	82	of	of	IN
cord-306948-wkisfz1m	410	83	the	the	DT
cord-306948-wkisfz1m	410	84	nucleocapsid	nucleocapsid	NNP
cord-306948-wkisfz1m	410	85	protein	protein	NN
cord-306948-wkisfz1m	410	86	is	be	VBZ
cord-306948-wkisfz1m	410	87	essential	essential	JJ
cord-306948-wkisfz1m	410	88	for	for	IN
cord-306948-wkisfz1m	410	89	virus	virus	NN
cord-306948-wkisfz1m	410	90	infectivity	infectivity	NN
cord-306948-wkisfz1m	410	91	Mutations	Mutations	NNPS
cord-306948-wkisfz1m	410	92	within	within	IN
cord-306948-wkisfz1m	410	93	the	the	DT
cord-306948-wkisfz1m	410	94	nuclear	nuclear	JJ
cord-306948-wkisfz1m	410	95	localization	localization	NN
cord-306948-wkisfz1m	410	96	signal	signal	NN
cord-306948-wkisfz1m	410	97	of	of	IN
cord-306948-wkisfz1m	410	98	the	the	DT
cord-306948-wkisfz1m	410	99	porcine	porcine	JJ
cord-306948-wkisfz1m	410	100	reproductive	reproductive	JJ
cord-306948-wkisfz1m	410	101	and	and	CC
cord-306948-wkisfz1m	410	102	respiratory	respiratory	JJ
cord-306948-wkisfz1m	410	103	syndrome	syndrome	NN
cord-306948-wkisfz1m	410	104	virus	virus	NN
cord-306948-wkisfz1m	410	105	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	410	106	protein	protein	NNP
cord-306948-wkisfz1m	411	1	attenuate	attenuate	VB
cord-306948-wkisfz1m	411	2	virus	virus	NN
cord-306948-wkisfz1m	411	3	replication	replication	NN
cord-306948-wkisfz1m	411	4	Cysteine	cysteine	NN
cord-306948-wkisfz1m	411	5	residues	residue	NNS
cord-306948-wkisfz1m	411	6	of	of	IN
cord-306948-wkisfz1m	411	7	the	the	DT
cord-306948-wkisfz1m	411	8	porcine	porcine	JJ
cord-306948-wkisfz1m	411	9	reproductive	reproductive	JJ
cord-306948-wkisfz1m	411	10	and	and	CC
cord-306948-wkisfz1m	411	11	respiratory	respiratory	JJ
cord-306948-wkisfz1m	411	12	syndrome	syndrome	NN
cord-306948-wkisfz1m	411	13	virus	virus	NN
cord-306948-wkisfz1m	411	14	small	small	JJ
cord-306948-wkisfz1m	411	15	envelope	envelope	NN
cord-306948-wkisfz1m	411	16	protein	protein	NN
cord-306948-wkisfz1m	411	17	are	be	VBP
cord-306948-wkisfz1m	411	18	non	non	JJ
cord-306948-wkisfz1m	411	19	-	-	JJ
cord-306948-wkisfz1m	411	20	essential	essential	JJ
cord-306948-wkisfz1m	411	21	for	for	IN
cord-306948-wkisfz1m	411	22	virus	virus	NN
cord-306948-wkisfz1m	411	23	infectivity	infectivity	NN
cord-306948-wkisfz1m	412	1	The	the	DT
cord-306948-wkisfz1m	412	2	small	small	JJ
cord-306948-wkisfz1m	412	3	envelope	envelope	NN
cord-306948-wkisfz1m	412	4	protein	protein	NN
cord-306948-wkisfz1m	412	5	of	of	IN
cord-306948-wkisfz1m	412	6	porcine	porcine	JJ
cord-306948-wkisfz1m	412	7	reproductive	reproductive	JJ
cord-306948-wkisfz1m	412	8	and	and	CC
cord-306948-wkisfz1m	412	9	respiratory	respiratory	JJ
cord-306948-wkisfz1m	412	10	syndrome	syndrome	NN
cord-306948-wkisfz1m	412	11	virus	virus	NN
cord-306948-wkisfz1m	412	12	possesses	possess	VBZ
cord-306948-wkisfz1m	412	13	ion	ion	NN
cord-306948-wkisfz1m	412	14	channel	channel	NN
cord-306948-wkisfz1m	412	15	protein	protein	NN
cord-306948-wkisfz1m	412	16	-	-	HYPH
cord-306948-wkisfz1m	412	17	like	like	JJ
cord-306948-wkisfz1m	412	18	properties	property	NNS
cord-306948-wkisfz1m	413	1	Nsp9	Nsp9	NNP
cord-306948-wkisfz1m	413	2	and	and	CC
cord-306948-wkisfz1m	413	3	Nsp10	Nsp10	NNP
cord-306948-wkisfz1m	413	4	contribute	contribute	VB
cord-306948-wkisfz1m	413	5	to	to	IN
cord-306948-wkisfz1m	413	6	the	the	DT
cord-306948-wkisfz1m	413	7	fatal	fatal	JJ
cord-306948-wkisfz1m	413	8	virulence	virulence	NN
cord-306948-wkisfz1m	413	9	of	of	IN
cord-306948-wkisfz1m	413	10	highly	highly	RB
cord-306948-wkisfz1m	413	11	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	413	12	porcine	porcine	JJ
cord-306948-wkisfz1m	413	13	reproductive	reproductive	JJ
cord-306948-wkisfz1m	413	14	and	and	CC
cord-306948-wkisfz1m	413	15	respiratory	respiratory	JJ
cord-306948-wkisfz1m	413	16	syndrome	syndrome	NN
cord-306948-wkisfz1m	413	17	virus	virus	NN
cord-306948-wkisfz1m	413	18	emerging	emerge	VBG
cord-306948-wkisfz1m	413	19	in	in	IN
cord-306948-wkisfz1m	413	20	China	China	NNP
cord-306948-wkisfz1m	413	21	Targeted	target	VBN
cord-306948-wkisfz1m	413	22	mutations	mutation	NNS
cord-306948-wkisfz1m	413	23	in	in	IN
cord-306948-wkisfz1m	413	24	a	a	DT
cord-306948-wkisfz1m	413	25	highly	highly	RB
cord-306948-wkisfz1m	413	26	conserved	conserve	VBN
cord-306948-wkisfz1m	413	27	motif	motif	NN
cord-306948-wkisfz1m	413	28	of	of	IN
cord-306948-wkisfz1m	413	29	the	the	DT
cord-306948-wkisfz1m	413	30	nsp1beta	nsp1beta	NNP
cord-306948-wkisfz1m	413	31	protein	protein	NN
cord-306948-wkisfz1m	414	1	impair	impair	VB
cord-306948-wkisfz1m	414	2	the	the	DT
cord-306948-wkisfz1m	414	3	interferon	interferon	NN
cord-306948-wkisfz1m	414	4	antagonizing	antagonize	VBG
cord-306948-wkisfz1m	414	5	activity	activity	NN
cord-306948-wkisfz1m	414	6	of	of	IN
cord-306948-wkisfz1m	414	7	porcine	porcine	JJ
cord-306948-wkisfz1m	414	8	reproductive	reproductive	JJ
cord-306948-wkisfz1m	414	9	and	and	CC
cord-306948-wkisfz1m	414	10	respiratory	respiratory	JJ
cord-306948-wkisfz1m	414	11	syndrome	syndrome	NN
cord-306948-wkisfz1m	414	12	virus	virus	NN
cord-306948-wkisfz1m	414	13	Chimeric	chimeric	JJ
cord-306948-wkisfz1m	414	14	viruses	virus	NNS
cord-306948-wkisfz1m	414	15	containing	contain	VBG
cord-306948-wkisfz1m	414	16	the	the	DT
cord-306948-wkisfz1m	414	17	N	n	CD
cord-306948-wkisfz1m	414	18	-	-	HYPH
cord-306948-wkisfz1m	414	19	terminal	terminal	NN
cord-306948-wkisfz1m	414	20	ectodomains	ectodomain	NNS
cord-306948-wkisfz1m	414	21	of	of	IN
cord-306948-wkisfz1m	414	22	GP5	GP5	NNP
cord-306948-wkisfz1m	414	23	and	and	CC
cord-306948-wkisfz1m	414	24	M	M	NNP
cord-306948-wkisfz1m	414	25	proteins	protein	NNS
cord-306948-wkisfz1m	414	26	of	of	IN
cord-306948-wkisfz1m	414	27	porcine	porcine	JJ
cord-306948-wkisfz1m	414	28	reproductive	reproductive	JJ
cord-306948-wkisfz1m	414	29	and	and	CC
cord-306948-wkisfz1m	414	30	respiratory	respiratory	JJ
cord-306948-wkisfz1m	414	31	syndrome	syndrome	NN
cord-306948-wkisfz1m	414	32	virus	virus	NN
cord-306948-wkisfz1m	414	33	do	do	VBP
cord-306948-wkisfz1m	414	34	not	not	RB
cord-306948-wkisfz1m	414	35	change	change	VB
cord-306948-wkisfz1m	414	36	the	the	DT
cord-306948-wkisfz1m	414	37	cellular	cellular	JJ
cord-306948-wkisfz1m	414	38	tropism	tropism	NN
cord-306948-wkisfz1m	414	39	of	of	IN
cord-306948-wkisfz1m	414	40	equine	equine	JJ
cord-306948-wkisfz1m	414	41	arteritis	arteritis	NN
cord-306948-wkisfz1m	414	42	virus	virus	NN
cord-306948-wkisfz1m	414	43	An	an	DT
cord-306948-wkisfz1m	414	44	infectious	infectious	JJ
cord-306948-wkisfz1m	414	45	cDNA	cdna	NN
cord-306948-wkisfz1m	414	46	clone	clone	NN
cord-306948-wkisfz1m	414	47	of	of	IN
cord-306948-wkisfz1m	414	48	a	a	DT
cord-306948-wkisfz1m	414	49	highly	highly	RB
cord-306948-wkisfz1m	414	50	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	414	51	porcine	porcine	JJ
cord-306948-wkisfz1m	414	52	reproductive	reproductive	JJ
cord-306948-wkisfz1m	414	53	and	and	CC
cord-306948-wkisfz1m	414	54	respiratory	respiratory	JJ
cord-306948-wkisfz1m	414	55	syndrome	syndrome	NN
cord-306948-wkisfz1m	414	56	virus	virus	NN
cord-306948-wkisfz1m	414	57	variant	variant	NN
cord-306948-wkisfz1m	414	58	associated	associate	VBN
cord-306948-wkisfz1m	414	59	with	with	IN
cord-306948-wkisfz1m	414	60	porcine	porcine	JJ
cord-306948-wkisfz1m	414	61	high	high	JJ
cord-306948-wkisfz1m	414	62	fever	fever	NN
cord-306948-wkisfz1m	414	63	syndrome	syndrome	NN
cord-306948-wkisfz1m	414	64	Infectious	infectious	JJ
cord-306948-wkisfz1m	414	65	transcripts	transcript	NNS
cord-306948-wkisfz1m	414	66	from	from	IN
cord-306948-wkisfz1m	414	67	cloned	clone	VBN
cord-306948-wkisfz1m	414	68	genomelength	genomelength	JJ
cord-306948-wkisfz1m	414	69	cDNA	cdna	NN
cord-306948-wkisfz1m	414	70	of	of	IN
cord-306948-wkisfz1m	414	71	porcine	porcine	JJ
cord-306948-wkisfz1m	414	72	reproductive	reproductive	JJ
cord-306948-wkisfz1m	414	73	and	and	CC
cord-306948-wkisfz1m	414	74	respiratory	respiratory	JJ
cord-306948-wkisfz1m	414	75	syndrome	syndrome	NN
cord-306948-wkisfz1m	414	76	virus	virus	NN
cord-306948-wkisfz1m	414	77	Lelystad	Lelystad	NNP
cord-306948-wkisfz1m	414	78	virus	virus	NN
cord-306948-wkisfz1m	414	79	,	,	,
cord-306948-wkisfz1m	414	80	the	the	DT
cord-306948-wkisfz1m	414	81	causative	causative	JJ
cord-306948-wkisfz1m	414	82	agent	agent	NN
cord-306948-wkisfz1m	414	83	of	of	IN
cord-306948-wkisfz1m	414	84	porcine	porcine	JJ
cord-306948-wkisfz1m	414	85	epidemic	epidemic	NN
cord-306948-wkisfz1m	414	86	abortion	abortion	NN
cord-306948-wkisfz1m	414	87	and	and	CC
cord-306948-wkisfz1m	414	88	respiratory	respiratory	JJ
cord-306948-wkisfz1m	414	89	syndrome	syndrome	NN
cord-306948-wkisfz1m	414	90	(	(	-LRB-
cord-306948-wkisfz1m	414	91	PEARS	PEARS	NNP
cord-306948-wkisfz1m	414	92	)	)	-RRB-
cord-306948-wkisfz1m	414	93	,	,	,
cord-306948-wkisfz1m	414	94	is	be	VBZ
cord-306948-wkisfz1m	414	95	related	relate	VBN
cord-306948-wkisfz1m	414	96	to	to	IN
cord-306948-wkisfz1m	414	97	LDV	LDV	NNP
cord-306948-wkisfz1m	414	98	and	and	CC
cord-306948-wkisfz1m	414	99	EAV	EAV	NNP
cord-306948-wkisfz1m	414	100	Recovery	Recovery	NNP
cord-306948-wkisfz1m	414	101	of	of	IN
cord-306948-wkisfz1m	414	102	cytopathogenic	cytopathogenic	NNP
cord-306948-wkisfz1m	414	103	and	and	CC
cord-306948-wkisfz1m	414	104	noncytopathogenic	noncytopathogenic	NNP
cord-306948-wkisfz1m	414	105	bovine	bovine	JJ
cord-306948-wkisfz1m	414	106	viral	viral	JJ
cord-306948-wkisfz1m	414	107	diarrhea	diarrhea	NN
cord-306948-wkisfz1m	414	108	viruses	virus	NNS
cord-306948-wkisfz1m	414	109	from	from	IN
cord-306948-wkisfz1m	414	110	cDNA	cdna	NN
cord-306948-wkisfz1m	414	111	constructs	construct	VBZ
cord-306948-wkisfz1m	414	112	Infectious	Infectious	NNP
cord-306948-wkisfz1m	414	113	RNA	RNA	NNP
cord-306948-wkisfz1m	414	114	transcribed	transcribe	VBD
cord-306948-wkisfz1m	414	115	from	from	IN
cord-306948-wkisfz1m	414	116	an	an	DT
cord-306948-wkisfz1m	414	117	engineered	engineer	VBN
cord-306948-wkisfz1m	414	118	full	full	JJ
cord-306948-wkisfz1m	414	119	-	-	HYPH
cord-306948-wkisfz1m	414	120	length	length	NN
cord-306948-wkisfz1m	414	121	cDNA	cdna	NN
cord-306948-wkisfz1m	414	122	template	template	NN
cord-306948-wkisfz1m	414	123	of	of	IN
cord-306948-wkisfz1m	414	124	the	the	DT
cord-306948-wkisfz1m	414	125	genome	genome	NN
cord-306948-wkisfz1m	414	126	of	of	IN
cord-306948-wkisfz1m	414	127	a	a	DT
cord-306948-wkisfz1m	414	128	pestivirus	pestivirus	JJ
cord-306948-wkisfz1m	414	129	Large	large	JJ
cord-306948-wkisfz1m	414	130	scale	scale	NN
cord-306948-wkisfz1m	414	131	comparative	comparative	JJ
cord-306948-wkisfz1m	414	132	codon	codon	NN
cord-306948-wkisfz1m	414	133	-	-	HYPH
cord-306948-wkisfz1m	414	134	pair	pair	NN
cord-306948-wkisfz1m	414	135	context	context	NN
cord-306948-wkisfz1m	414	136	analysis	analysis	NN
cord-306948-wkisfz1m	414	137	unveils	unveil	VBZ
cord-306948-wkisfz1m	414	138	general	general	JJ
cord-306948-wkisfz1m	414	139	rules	rule	NNS
cord-306948-wkisfz1m	414	140	that	that	WDT
cord-306948-wkisfz1m	414	141	fine	fine	JJ
cord-306948-wkisfz1m	414	142	-	-	HYPH
cord-306948-wkisfz1m	414	143	tune	tune	NN
cord-306948-wkisfz1m	414	144	evolution	evolution	NN
cord-306948-wkisfz1m	414	145	of	of	IN
cord-306948-wkisfz1m	414	146	mRNA	mRNA	NNP
cord-306948-wkisfz1m	414	147	primary	primary	JJ
cord-306948-wkisfz1m	414	148	structure	structure	NN
cord-306948-wkisfz1m	415	1	Live	live	VB
cord-306948-wkisfz1m	415	2	attenuated	attenuated	JJ
cord-306948-wkisfz1m	415	3	influenza	influenza	NN
cord-306948-wkisfz1m	415	4	virus	virus	NN
cord-306948-wkisfz1m	415	5	vaccines	vaccine	NNS
cord-306948-wkisfz1m	415	6	by	by	IN
cord-306948-wkisfz1m	415	7	computer	computer	NN
cord-306948-wkisfz1m	415	8	-	-	HYPH
cord-306948-wkisfz1m	415	9	aided	aid	VBN
cord-306948-wkisfz1m	415	10	rational	rational	JJ
cord-306948-wkisfz1m	415	11	design	design	NN
cord-306948-wkisfz1m	415	12	Isolation	isolation	NN
cord-306948-wkisfz1m	415	13	and	and	CC
cord-306948-wkisfz1m	415	14	serological	serological	JJ
cord-306948-wkisfz1m	415	15	characterization	characterization	NN
cord-306948-wkisfz1m	415	16	of	of	IN
cord-306948-wkisfz1m	415	17	porcine	porcine	JJ
cord-306948-wkisfz1m	415	18	reproductive	reproductive	JJ
cord-306948-wkisfz1m	415	19	and	and	CC
cord-306948-wkisfz1m	415	20	respiratory	respiratory	JJ
cord-306948-wkisfz1m	415	21	syndrome	syndrome	NN
cord-306948-wkisfz1m	415	22	(	(	-LRB-
cord-306948-wkisfz1m	415	23	PRRS	PRRS	NNP
cord-306948-wkisfz1m	415	24	)	)	-RRB-
cord-306948-wkisfz1m	415	25	viruses	virus	NNS
cord-306948-wkisfz1m	415	26	from	from	IN
cord-306948-wkisfz1m	415	27	pigs	pig	NNS
cord-306948-wkisfz1m	415	28	with	with	IN
cord-306948-wkisfz1m	415	29	reproductive	reproductive	JJ
cord-306948-wkisfz1m	415	30	and	and	CC
cord-306948-wkisfz1m	415	31	respiratory	respiratory	JJ
cord-306948-wkisfz1m	415	32	disorders	disorder	NNS
cord-306948-wkisfz1m	415	33	in	in	IN
cord-306948-wkisfz1m	415	34	Japan	Japan	NNP
cord-306948-wkisfz1m	415	35	Comparison	Comparison	NNP
cord-306948-wkisfz1m	415	36	of	of	IN
cord-306948-wkisfz1m	415	37	the	the	DT
cord-306948-wkisfz1m	415	38	structural	structural	JJ
cord-306948-wkisfz1m	415	39	protein	protein	NN
cord-306948-wkisfz1m	415	40	-	-	HYPH
cord-306948-wkisfz1m	415	41	coding	code	VBG
cord-306948-wkisfz1m	415	42	sequences	sequence	NNS
cord-306948-wkisfz1m	415	43	of	of	IN
cord-306948-wkisfz1m	415	44	the	the	DT
cord-306948-wkisfz1m	415	45	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	415	46	and	and	CC
cord-306948-wkisfz1m	415	47	Lelystad	Lelystad	NNP
cord-306948-wkisfz1m	415	48	virusstrains	virusstrain	NNS
cord-306948-wkisfz1m	415	49	of	of	IN
cord-306948-wkisfz1m	415	50	the	the	DT
cord-306948-wkisfz1m	415	51	PRRS	PRRS	NNP
cord-306948-wkisfz1m	415	52	virus	virus	NN
cord-306948-wkisfz1m	416	1	The	the	DT
cord-306948-wkisfz1m	416	2	role	role	NN
cord-306948-wkisfz1m	416	3	of	of	IN
cord-306948-wkisfz1m	416	4	porcine	porcine	JJ
cord-306948-wkisfz1m	416	5	reproductive	reproductive	JJ
cord-306948-wkisfz1m	416	6	and	and	CC
cord-306948-wkisfz1m	416	7	respiratory	respiratory	JJ
cord-306948-wkisfz1m	416	8	syndrome	syndrome	NN
cord-306948-wkisfz1m	416	9	(	(	-LRB-
cord-306948-wkisfz1m	416	10	PRRS	PRRS	NNP
cord-306948-wkisfz1m	416	11	)	)	-RRB-
cord-306948-wkisfz1m	416	12	virus	virus	NN
cord-306948-wkisfz1m	416	13	structural	structural	JJ
cord-306948-wkisfz1m	416	14	and	and	CC
cord-306948-wkisfz1m	416	15	non	non	JJ
cord-306948-wkisfz1m	416	16	-	-	JJ
cord-306948-wkisfz1m	416	17	structural	structural	JJ
cord-306948-wkisfz1m	416	18	proteins	protein	NNS
cord-306948-wkisfz1m	416	19	in	in	IN
cord-306948-wkisfz1m	416	20	virus	virus	NN
cord-306948-wkisfz1m	416	21	pathogenesis	pathogenesis	NN
cord-306948-wkisfz1m	416	22	Arterivirus	Arterivirus	NNP
cord-306948-wkisfz1m	416	23	np1	np1	NN
cord-306948-wkisfz1m	416	24	modulates	modulate	VBZ
cord-306948-wkisfz1m	416	25	the	the	DT
cord-306948-wkisfz1m	416	26	accumulation	accumulation	NN
cord-306948-wkisfz1m	416	27	of	of	IN
cord-306948-wkisfz1m	416	28	minus	minus	JJ
cord-306948-wkisfz1m	416	29	-	-	HYPH
cord-306948-wkisfz1m	416	30	strand	strand	NN
cord-306948-wkisfz1m	416	31	templates	template	NNS
cord-306948-wkisfz1m	416	32	to	to	TO
cord-306948-wkisfz1m	416	33	control	control	VB
cord-306948-wkisfz1m	416	34	the	the	DT
cord-306948-wkisfz1m	416	35	relative	relative	JJ
cord-306948-wkisfz1m	416	36	abundance	abundance	NN
cord-306948-wkisfz1m	416	37	of	of	IN
cord-306948-wkisfz1m	416	38	viral	viral	JJ
cord-306948-wkisfz1m	416	39	mRNAs	mRNAs	.
cord-306948-wkisfz1m	417	1	Porcine	porcine	JJ
cord-306948-wkisfz1m	417	2	reproductive	reproductive	JJ
cord-306948-wkisfz1m	417	3	and	and	CC
cord-306948-wkisfz1m	417	4	respiratory	respiratory	JJ
cord-306948-wkisfz1m	417	5	syndrome	syndrome	NN
cord-306948-wkisfz1m	417	6	virus	virus	NN
cord-306948-wkisfz1m	417	7	comparison	comparison	NN
cord-306948-wkisfz1m	417	8	:	:	:
cord-306948-wkisfz1m	417	9	divergent	divergent	JJ
cord-306948-wkisfz1m	417	10	evolution	evolution	NN
cord-306948-wkisfz1m	417	11	on	on	IN
cord-306948-wkisfz1m	417	12	two	two	CD
cord-306948-wkisfz1m	417	13	continents	continent	NNS
cord-306948-wkisfz1m	417	14	Establishment	Establishment	NNP
cord-306948-wkisfz1m	417	15	of	of	IN
cord-306948-wkisfz1m	417	16	a	a	DT
cord-306948-wkisfz1m	417	17	DNA	dna	NN
cord-306948-wkisfz1m	417	18	-	-	HYPH
cord-306948-wkisfz1m	417	19	launched	launch	VBN
cord-306948-wkisfz1m	417	20	infectious	infectious	JJ
cord-306948-wkisfz1m	417	21	clone	clone	NN
cord-306948-wkisfz1m	417	22	for	for	IN
cord-306948-wkisfz1m	417	23	a	a	DT
cord-306948-wkisfz1m	417	24	highly	highly	RB
cord-306948-wkisfz1m	417	25	pneumovirulent	pneumovirulent	JJ
cord-306948-wkisfz1m	417	26	strain	strain	NN
cord-306948-wkisfz1m	417	27	of	of	IN
cord-306948-wkisfz1m	417	28	type	type	NN
cord-306948-wkisfz1m	417	29	2	2	CD
cord-306948-wkisfz1m	417	30	porcine	porcine	JJ
cord-306948-wkisfz1m	417	31	reproductive	reproductive	JJ
cord-306948-wkisfz1m	417	32	and	and	CC
cord-306948-wkisfz1m	417	33	respiratory	respiratory	JJ
cord-306948-wkisfz1m	417	34	syndrome	syndrome	NN
cord-306948-wkisfz1m	417	35	virus	virus	NN
cord-306948-wkisfz1m	417	36	:	:	:
cord-306948-wkisfz1m	417	37	identification	identification	NN
cord-306948-wkisfz1m	417	38	and	and	CC
cord-306948-wkisfz1m	417	39	in	in	IN
cord-306948-wkisfz1m	417	40	vitro	vitro	FW
cord-306948-wkisfz1m	417	41	and	and	CC
cord-306948-wkisfz1m	417	42	in	in	IN
cord-306948-wkisfz1m	417	43	vivo	vivo	NN
cord-306948-wkisfz1m	417	44	characterization	characterization	NN
cord-306948-wkisfz1m	417	45	of	of	IN
cord-306948-wkisfz1m	417	46	a	a	DT
cord-306948-wkisfz1m	417	47	large	large	JJ
cord-306948-wkisfz1m	417	48	spontaneous	spontaneous	JJ
cord-306948-wkisfz1m	417	49	deletion	deletion	NN
cord-306948-wkisfz1m	417	50	in	in	IN
cord-306948-wkisfz1m	417	51	the	the	DT
cord-306948-wkisfz1m	417	52	nsp2	nsp2	NNP
cord-306948-wkisfz1m	417	53	region	region	NN
cord-306948-wkisfz1m	417	54	Attenuation	attenuation	NN
cord-306948-wkisfz1m	417	55	of	of	IN
cord-306948-wkisfz1m	417	56	porcine	porcine	JJ
cord-306948-wkisfz1m	417	57	reproductive	reproductive	JJ
cord-306948-wkisfz1m	417	58	and	and	CC
cord-306948-wkisfz1m	417	59	respiratory	respiratory	JJ
cord-306948-wkisfz1m	417	60	syndrome	syndrome	NN
cord-306948-wkisfz1m	417	61	virus	virus	NN
cord-306948-wkisfz1m	417	62	by	by	IN
cord-306948-wkisfz1m	417	63	molecular	molecular	JJ
cord-306948-wkisfz1m	417	64	breeding	breeding	NN
cord-306948-wkisfz1m	417	65	of	of	IN
cord-306948-wkisfz1m	417	66	virus	virus	NN
cord-306948-wkisfz1m	417	67	envelope	envelope	NN
cord-306948-wkisfz1m	417	68	genes	gene	NNS
cord-306948-wkisfz1m	417	69	from	from	IN
cord-306948-wkisfz1m	417	70	genetically	genetically	RB
cord-306948-wkisfz1m	417	71	divergent	divergent	JJ
cord-306948-wkisfz1m	417	72	strains	strain	NNS
cord-306948-wkisfz1m	418	1	Computer	computer	NN
cord-306948-wkisfz1m	418	2	-	-	HYPH
cord-306948-wkisfz1m	418	3	aided	aid	VBN
cord-306948-wkisfz1m	418	4	codon	codon	NN
cord-306948-wkisfz1m	418	5	-	-	HYPH
cord-306948-wkisfz1m	418	6	pairs	pair	NNS
cord-306948-wkisfz1m	418	7	deoptimization	deoptimization	NN
cord-306948-wkisfz1m	418	8	of	of	IN
cord-306948-wkisfz1m	418	9	the	the	DT
cord-306948-wkisfz1m	418	10	major	major	JJ
cord-306948-wkisfz1m	418	11	envelope	envelope	NN
cord-306948-wkisfz1m	418	12	GP5	GP5	NNP
cord-306948-wkisfz1m	418	13	gene	gene	NN
cord-306948-wkisfz1m	418	14	attenuates	attenuate	VBZ
cord-306948-wkisfz1m	418	15	porcine	porcine	JJ
cord-306948-wkisfz1m	418	16	reproductive	reproductive	JJ
cord-306948-wkisfz1m	418	17	and	and	CC
cord-306948-wkisfz1m	418	18	respiratory	respiratory	JJ
cord-306948-wkisfz1m	418	19	syndrome	syndrome	NN
cord-306948-wkisfz1m	418	20	virus	virus	NN
cord-306948-wkisfz1m	418	21	Generation	generation	NN
cord-306948-wkisfz1m	418	22	of	of	IN
cord-306948-wkisfz1m	418	23	an	an	DT
cord-306948-wkisfz1m	418	24	infectious	infectious	JJ
cord-306948-wkisfz1m	418	25	clone	clone	NN
cord-306948-wkisfz1m	418	26	of	of	IN
cord-306948-wkisfz1m	418	27	VR-2332	vr-2332	NN
cord-306948-wkisfz1m	418	28	,	,	,
cord-306948-wkisfz1m	418	29	a	a	DT
cord-306948-wkisfz1m	418	30	highly	highly	RB
cord-306948-wkisfz1m	418	31	virulent	virulent	JJ
cord-306948-wkisfz1m	418	32	North	north	JJ
cord-306948-wkisfz1m	418	33	American	american	JJ
cord-306948-wkisfz1m	418	34	type	type	NN
cord-306948-wkisfz1m	418	35	isolate	isolate	NN
cord-306948-wkisfz1m	418	36	of	of	IN
cord-306948-wkisfz1m	418	37	porcine	porcine	JJ
cord-306948-wkisfz1m	418	38	reproductive	reproductive	JJ
cord-306948-wkisfz1m	418	39	and	and	CC
cord-306948-wkisfz1m	418	40	respiratory	respiratory	JJ
cord-306948-wkisfz1m	418	41	syndrome	syndrome	NN
cord-306948-wkisfz1m	418	42	virus	virus	NN
cord-306948-wkisfz1m	418	43	Epitope	Epitope	NNP
cord-306948-wkisfz1m	418	44	mapping	mapping	NN
cord-306948-wkisfz1m	418	45	porcine	porcine	JJ
cord-306948-wkisfz1m	418	46	reproductive	reproductive	JJ
cord-306948-wkisfz1m	418	47	and	and	CC
cord-306948-wkisfz1m	418	48	respiratory	respiratory	JJ
cord-306948-wkisfz1m	418	49	syndrome	syndrome	NN
cord-306948-wkisfz1m	418	50	virus	virus	NN
cord-306948-wkisfz1m	418	51	by	by	IN
cord-306948-wkisfz1m	418	52	phage	phage	NN
cord-306948-wkisfz1m	418	53	display	display	NN
cord-306948-wkisfz1m	418	54	:	:	:
cord-306948-wkisfz1m	419	1	the	the	DT
cord-306948-wkisfz1m	419	2	nsp2	nsp2	NNP
cord-306948-wkisfz1m	419	3	fragment	fragment	NN
cord-306948-wkisfz1m	419	4	of	of	IN
cord-306948-wkisfz1m	419	5	the	the	DT
cord-306948-wkisfz1m	419	6	replicase	replicase	NNP
cord-306948-wkisfz1m	419	7	polyprotein	polyprotein	NNP
cord-306948-wkisfz1m	419	8	contains	contain	VBZ
cord-306948-wkisfz1m	419	9	a	a	DT
cord-306948-wkisfz1m	419	10	cluster	cluster	NN
cord-306948-wkisfz1m	419	11	of	of	IN
cord-306948-wkisfz1m	419	12	B	b	NN
cord-306948-wkisfz1m	419	13	-	-	HYPH
cord-306948-wkisfz1m	419	14	cell	cell	NN
cord-306948-wkisfz1m	419	15	epitopes	epitope	NNS
cord-306948-wkisfz1m	420	1	Nidovirus	Nidovirus	NNP
cord-306948-wkisfz1m	420	2	transcription	transcription	NN
cord-306948-wkisfz1m	420	3	:	:	:
cord-306948-wkisfz1m	420	4	how	how	WRB
cord-306948-wkisfz1m	420	5	to	to	TO
cord-306948-wkisfz1m	420	6	make	make	VB
cord-306948-wkisfz1m	420	7	sense	sense	NN
cord-306948-wkisfz1m	421	1	Functional	functional	JJ
cord-306948-wkisfz1m	421	2	mapping	mapping	NN
cord-306948-wkisfz1m	421	3	of	of	IN
cord-306948-wkisfz1m	421	4	the	the	DT
cord-306948-wkisfz1m	421	5	porcine	porcine	JJ
cord-306948-wkisfz1m	421	6	reproductive	reproductive	JJ
cord-306948-wkisfz1m	421	7	and	and	CC
cord-306948-wkisfz1m	421	8	respiratory	respiratory	JJ
cord-306948-wkisfz1m	421	9	syndrome	syndrome	NN
cord-306948-wkisfz1m	421	10	virus	virus	NN
cord-306948-wkisfz1m	421	11	capsid	capsid	NN
cord-306948-wkisfz1m	421	12	protein	protein	NN
cord-306948-wkisfz1m	421	13	nuclear	nuclear	JJ
cord-306948-wkisfz1m	421	14	localization	localization	NN
cord-306948-wkisfz1m	421	15	signal	signal	NN
cord-306948-wkisfz1m	421	16	and	and	CC
cord-306948-wkisfz1m	421	17	its	-PRON-	PRP$
cord-306948-wkisfz1m	421	18	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	421	19	association	association	NN
cord-306948-wkisfz1m	421	20	Porcine	porcine	JJ
cord-306948-wkisfz1m	421	21	reproductive	reproductive	JJ
cord-306948-wkisfz1m	421	22	and	and	CC
cord-306948-wkisfz1m	421	23	respiratory	respiratory	JJ
cord-306948-wkisfz1m	421	24	syndrome	syndrome	NN
cord-306948-wkisfz1m	421	25	virus	virus	NN
cord-306948-wkisfz1m	421	26	as	as	IN
cord-306948-wkisfz1m	421	27	a	a	DT
cord-306948-wkisfz1m	421	28	vector	vector	NN
cord-306948-wkisfz1m	421	29	:	:	:
cord-306948-wkisfz1m	421	30	immunogenicity	immunogenicity	NN
cord-306948-wkisfz1m	421	31	of	of	IN
cord-306948-wkisfz1m	421	32	green	green	JJ
cord-306948-wkisfz1m	421	33	fluorescent	fluorescent	NN
cord-306948-wkisfz1m	421	34	protein	protein	NN
cord-306948-wkisfz1m	421	35	and	and	CC
cord-306948-wkisfz1m	421	36	porcine	porcine	JJ
cord-306948-wkisfz1m	421	37	circovirus	circovirus	JJ
cord-306948-wkisfz1m	421	38	type	type	NN
cord-306948-wkisfz1m	421	39	2	2	CD
cord-306948-wkisfz1m	421	40	capsid	capsid	NN
cord-306948-wkisfz1m	421	41	expressed	express	VBN
cord-306948-wkisfz1m	421	42	from	from	IN
cord-306948-wkisfz1m	421	43	dedicated	dedicated	JJ
cord-306948-wkisfz1m	421	44	subgenomic	subgenomic	NNP
cord-306948-wkisfz1m	421	45	RNAs	rna	NNS
cord-306948-wkisfz1m	421	46	Successful	successful	JJ
cord-306948-wkisfz1m	421	47	propagation	propagation	NN
cord-306948-wkisfz1m	421	48	of	of	IN
cord-306948-wkisfz1m	421	49	flavivirus	flavivirus	JJ
cord-306948-wkisfz1m	421	50	infectious	infectious	JJ
cord-306948-wkisfz1m	421	51	cDNAs	cDNAs	-RRB-
cord-306948-wkisfz1m	421	52	by	by	IN
cord-306948-wkisfz1m	421	53	a	a	DT
cord-306948-wkisfz1m	421	54	novel	novel	JJ
cord-306948-wkisfz1m	421	55	method	method	NN
cord-306948-wkisfz1m	421	56	to	to	TO
cord-306948-wkisfz1m	421	57	reduce	reduce	VB
cord-306948-wkisfz1m	421	58	the	the	DT
cord-306948-wkisfz1m	421	59	cryptic	cryptic	JJ
cord-306948-wkisfz1m	421	60	bacterial	bacterial	JJ
cord-306948-wkisfz1m	421	61	promoter	promoter	NN
cord-306948-wkisfz1m	421	62	activity	activity	NN
cord-306948-wkisfz1m	421	63	of	of	IN
cord-306948-wkisfz1m	421	64	virus	virus	NN
cord-306948-wkisfz1m	421	65	genomes	genome	NNS
cord-306948-wkisfz1m	421	66	Cloned	clone	VBN
cord-306948-wkisfz1m	421	67	Ppliovirus	Ppliovirus	NNP
cord-306948-wkisfz1m	421	68	complementary	complementary	JJ
cord-306948-wkisfz1m	421	69	-	-	HYPH
cord-306948-wkisfz1m	421	70	DNA	dna	NN
cord-306948-wkisfz1m	421	71	is	be	VBZ
cord-306948-wkisfz1m	421	72	infectious	infectious	JJ
cord-306948-wkisfz1m	421	73	in	in	IN
cord-306948-wkisfz1m	421	74	mammalian	mammalian	JJ
cord-306948-wkisfz1m	421	75	-	-	HYPH
cord-306948-wkisfz1m	421	76	cells	cell	NNS
cord-306948-wkisfz1m	421	77	Recovery	recovery	NN
cord-306948-wkisfz1m	421	78	of	of	IN
cord-306948-wkisfz1m	421	79	viable	viable	JJ
cord-306948-wkisfz1m	421	80	porcine	porcine	JJ
cord-306948-wkisfz1m	421	81	reproductive	reproductive	JJ
cord-306948-wkisfz1m	421	82	and	and	CC
cord-306948-wkisfz1m	421	83	respiratory	respiratory	JJ
cord-306948-wkisfz1m	421	84	syndrome	syndrome	NN
cord-306948-wkisfz1m	421	85	virus	virus	NN
cord-306948-wkisfz1m	421	86	from	from	IN
cord-306948-wkisfz1m	421	87	an	an	DT
cord-306948-wkisfz1m	421	88	infectious	infectious	JJ
cord-306948-wkisfz1m	421	89	clone	clone	NN
cord-306948-wkisfz1m	421	90	containing	contain	VBG
cord-306948-wkisfz1m	421	91	a	a	DT
cord-306948-wkisfz1m	421	92	partial	partial	JJ
cord-306948-wkisfz1m	421	93	deletion	deletion	NN
cord-306948-wkisfz1m	421	94	within	within	IN
cord-306948-wkisfz1m	421	95	the	the	DT
cord-306948-wkisfz1m	421	96	Nsp2-encoding	nsp2-encode	VBG
cord-306948-wkisfz1m	421	97	region	region	NN
cord-306948-wkisfz1m	422	1	The	the	DT
cord-306948-wkisfz1m	422	2	localization	localization	NN
cord-306948-wkisfz1m	422	3	of	of	IN
cord-306948-wkisfz1m	422	4	porcine	porcine	JJ
cord-306948-wkisfz1m	422	5	reproductive	reproductive	JJ
cord-306948-wkisfz1m	422	6	and	and	CC
cord-306948-wkisfz1m	422	7	respiratory	respiratory	JJ
cord-306948-wkisfz1m	422	8	syndrome	syndrome	NN
cord-306948-wkisfz1m	422	9	virus	virus	NN
cord-306948-wkisfz1m	422	10	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	422	11	protein	protein	NN
cord-306948-wkisfz1m	422	12	to	to	IN
cord-306948-wkisfz1m	422	13	the	the	DT
cord-306948-wkisfz1m	422	14	nucleolus	nucleolus	NN
cord-306948-wkisfz1m	422	15	of	of	IN
cord-306948-wkisfz1m	422	16	infected	infected	JJ
cord-306948-wkisfz1m	422	17	cells	cell	NNS
cord-306948-wkisfz1m	422	18	and	and	CC
cord-306948-wkisfz1m	422	19	identification	identification	NN
cord-306948-wkisfz1m	422	20	of	of	IN
cord-306948-wkisfz1m	422	21	a	a	DT
cord-306948-wkisfz1m	422	22	potential	potential	JJ
cord-306948-wkisfz1m	422	23	nucleolar	nucleolar	JJ
cord-306948-wkisfz1m	422	24	localization	localization	NN
cord-306948-wkisfz1m	422	25	signal	signal	NN
cord-306948-wkisfz1m	422	26	sequence	sequence	NN
cord-306948-wkisfz1m	422	27	Peptide	peptide	NN
cord-306948-wkisfz1m	422	28	domains	domain	NNS
cord-306948-wkisfz1m	422	29	involved	involve	VBN
cord-306948-wkisfz1m	422	30	in	in	IN
cord-306948-wkisfz1m	422	31	the	the	DT
cord-306948-wkisfz1m	422	32	localization	localization	NN
cord-306948-wkisfz1m	422	33	of	of	IN
cord-306948-wkisfz1m	422	34	the	the	DT
cord-306948-wkisfz1m	422	35	porcine	porcine	JJ
cord-306948-wkisfz1m	422	36	reproductive	reproductive	JJ
cord-306948-wkisfz1m	422	37	and	and	CC
cord-306948-wkisfz1m	422	38	respiratory	respiratory	JJ
cord-306948-wkisfz1m	422	39	syndrome	syndrome	NN
cord-306948-wkisfz1m	422	40	virus	virus	NN
cord-306948-wkisfz1m	422	41	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	422	42	protein	protein	NN
cord-306948-wkisfz1m	422	43	to	to	IN
cord-306948-wkisfz1m	422	44	the	the	DT
cord-306948-wkisfz1m	422	45	nucleolus	nucleolus	NN
cord-306948-wkisfz1m	422	46	Nucleolar	Nucleolar	NNP
cord-306948-wkisfz1m	422	47	-	-	HYPH
cord-306948-wkisfz1m	422	48	cytoplasmic	cytoplasmic	JJ
cord-306948-wkisfz1m	422	49	shuttling	shuttling	NN
cord-306948-wkisfz1m	422	50	of	of	IN
cord-306948-wkisfz1m	422	51	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	422	52	nucleocapsid	nucleocapsid	NNP
cord-306948-wkisfz1m	422	53	protein	protein	NNP
cord-306948-wkisfz1m	422	54	:	:	:
cord-306948-wkisfz1m	422	55	a	a	DT
cord-306948-wkisfz1m	422	56	simple	simple	JJ
cord-306948-wkisfz1m	422	57	case	case	NN
cord-306948-wkisfz1m	422	58	of	of	IN
cord-306948-wkisfz1m	422	59	molecular	molecular	JJ
cord-306948-wkisfz1m	422	60	mimicry	mimicry	NN
cord-306948-wkisfz1m	422	61	or	or	CC
cord-306948-wkisfz1m	422	62	the	the	DT
cord-306948-wkisfz1m	422	63	complex	complex	JJ
cord-306948-wkisfz1m	422	64	regulation	regulation	NN
cord-306948-wkisfz1m	422	65	by	by	IN
cord-306948-wkisfz1m	422	66	nuclear	nuclear	JJ
cord-306948-wkisfz1m	422	67	import	import	NN
cord-306948-wkisfz1m	422	68	,	,	,
cord-306948-wkisfz1m	422	69	nucleolar	nucleolar	JJ
cord-306948-wkisfz1m	422	70	localization	localization	NN
cord-306948-wkisfz1m	422	71	and	and	CC
cord-306948-wkisfz1m	422	72	nuclear	nuclear	JJ
cord-306948-wkisfz1m	422	73	export	export	NN
cord-306948-wkisfz1m	422	74	signal	signal	NN
cord-306948-wkisfz1m	422	75	sequences	sequence	NNS
cord-306948-wkisfz1m	422	76	Replication	replication	NN
cord-306948-wkisfz1m	422	77	-	-	HYPH
cord-306948-wkisfz1m	422	78	competent	competent	JJ
cord-306948-wkisfz1m	422	79	recombinant	recombinant	JJ
cord-306948-wkisfz1m	422	80	porcine	porcine	JJ
cord-306948-wkisfz1m	422	81	reproductive	reproductive	JJ
cord-306948-wkisfz1m	422	82	and	and	CC
cord-306948-wkisfz1m	422	83	respiratory	respiratory	JJ
cord-306948-wkisfz1m	422	84	syndrome	syndrome	NN
cord-306948-wkisfz1m	422	85	(	(	-LRB-
cord-306948-wkisfz1m	422	86	PRRS	PRRS	NNP
cord-306948-wkisfz1m	422	87	)	)	-RRB-
cord-306948-wkisfz1m	423	1	viruses	virus	NNS
cord-306948-wkisfz1m	423	2	expressing	express	VBG
cord-306948-wkisfz1m	423	3	indicator	indicator	NN
cord-306948-wkisfz1m	423	4	proteins	protein	NNS
cord-306948-wkisfz1m	423	5	and	and	CC
cord-306948-wkisfz1m	423	6	antiviral	antiviral	JJ
cord-306948-wkisfz1m	423	7	cytokines	cytokine	NNS
cord-306948-wkisfz1m	424	1	A	a	DT
cord-306948-wkisfz1m	424	2	contemporary	contemporary	JJ
cord-306948-wkisfz1m	424	3	view	view	NN
cord-306948-wkisfz1m	424	4	of	of	IN
cord-306948-wkisfz1m	424	5	coronavirus	coronavirus	NN
cord-306948-wkisfz1m	424	6	transcription	transcription	NN
cord-306948-wkisfz1m	424	7	Reverse	reverse	NN
cord-306948-wkisfz1m	424	8	genetics	genetics	NN
cord-306948-wkisfz1m	424	9	with	with	IN
cord-306948-wkisfz1m	424	10	a	a	DT
cord-306948-wkisfz1m	424	11	fulllength	fulllength	JJ
cord-306948-wkisfz1m	424	12	infectious	infectious	JJ
cord-306948-wkisfz1m	424	13	cDNA	cdna	NN
cord-306948-wkisfz1m	424	14	of	of	IN
cord-306948-wkisfz1m	424	15	the	the	DT
cord-306948-wkisfz1m	424	16	Middle	Middle	NNP
cord-306948-wkisfz1m	424	17	East	East	NNP
cord-306948-wkisfz1m	424	18	respiratory	respiratory	JJ
cord-306948-wkisfz1m	424	19	syndrome	syndrome	NN
cord-306948-wkisfz1m	424	20	coronavirus	coronavirus	NN
cord-306948-wkisfz1m	424	21	Determination	determination	NN
cord-306948-wkisfz1m	424	22	of	of	IN
cord-306948-wkisfz1m	424	23	the	the	DT
cord-306948-wkisfz1m	424	24	complete	complete	JJ
cord-306948-wkisfz1m	424	25	nucleotide	nucleotide	JJ
cord-306948-wkisfz1m	424	26	sequence	sequence	NN
cord-306948-wkisfz1m	424	27	of	of	IN
cord-306948-wkisfz1m	424	28	a	a	DT
cord-306948-wkisfz1m	424	29	vaccine	vaccine	NN
cord-306948-wkisfz1m	424	30	strain	strain	NN
cord-306948-wkisfz1m	424	31	of	of	IN
cord-306948-wkisfz1m	424	32	porcine	porcine	JJ
cord-306948-wkisfz1m	424	33	reproductive	reproductive	JJ
cord-306948-wkisfz1m	424	34	and	and	CC
cord-306948-wkisfz1m	424	35	respiratory	respiratory	JJ
cord-306948-wkisfz1m	424	36	syndrome	syndrome	NN
cord-306948-wkisfz1m	424	37	virus	virus	NN
cord-306948-wkisfz1m	424	38	and	and	CC
cord-306948-wkisfz1m	424	39	identification	identification	NN
cord-306948-wkisfz1m	424	40	of	of	IN
cord-306948-wkisfz1m	424	41	the	the	DT
cord-306948-wkisfz1m	424	42	Nsp2	Nsp2	NNP
cord-306948-wkisfz1m	424	43	gene	gene	NN
cord-306948-wkisfz1m	424	44	with	with	IN
cord-306948-wkisfz1m	424	45	a	a	DT
cord-306948-wkisfz1m	424	46	unique	unique	JJ
cord-306948-wkisfz1m	424	47	insertion	insertion	NN
cord-306948-wkisfz1m	424	48	Isolation	isolation	NN
cord-306948-wkisfz1m	424	49	of	of	IN
cord-306948-wkisfz1m	424	50	porcine	porcine	JJ
cord-306948-wkisfz1m	424	51	reproductive	reproductive	JJ
cord-306948-wkisfz1m	424	52	and	and	CC
cord-306948-wkisfz1m	424	53	respiratory	respiratory	JJ
cord-306948-wkisfz1m	424	54	syndrome	syndrome	NN
cord-306948-wkisfz1m	424	55	(	(	-LRB-
cord-306948-wkisfz1m	424	56	PRRS	PRRS	NNP
cord-306948-wkisfz1m	424	57	)	)	-RRB-
cord-306948-wkisfz1m	424	58	virus	virus	NN
cord-306948-wkisfz1m	424	59	from	from	IN
cord-306948-wkisfz1m	424	60	Heko	Heko	NNP
cord-306948-wkisfz1m	424	61	-	-	HYPH
cord-306948-wkisfz1m	424	62	Heko	Heko	NNP
cord-306948-wkisfz1m	424	63	disease	disease	NN
cord-306948-wkisfz1m	424	64	of	of	IN
cord-306948-wkisfz1m	424	65	pigs	pig	NNS
cord-306948-wkisfz1m	424	66	Arterivirus	Arterivirus	NNP
cord-306948-wkisfz1m	424	67	molecular	molecular	JJ
cord-306948-wkisfz1m	424	68	biology	biology	NN
cord-306948-wkisfz1m	424	69	and	and	CC
cord-306948-wkisfz1m	424	70	pathogenesis	pathogenesis	NN
cord-306948-wkisfz1m	425	1	The	the	DT
cord-306948-wkisfz1m	425	2	molecular	molecular	JJ
cord-306948-wkisfz1m	425	3	biology	biology	NN
cord-306948-wkisfz1m	425	4	of	of	IN
cord-306948-wkisfz1m	425	5	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	426	1	The	the	DT
cord-306948-wkisfz1m	426	2	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	426	3	Nsp2	Nsp2	NNP
cord-306948-wkisfz1m	426	4	protease	protease	NN
cord-306948-wkisfz1m	426	5	,	,	,
cord-306948-wkisfz1m	426	6	An	an	DT
cord-306948-wkisfz1m	426	7	unusual	unusual	JJ
cord-306948-wkisfz1m	426	8	cysteine	cysteine	NN
cord-306948-wkisfz1m	426	9	protease	protease	NN
cord-306948-wkisfz1m	426	10	with	with	IN
cord-306948-wkisfz1m	426	11	primary	primary	JJ
cord-306948-wkisfz1m	426	12	structure	structure	NN
cord-306948-wkisfz1m	426	13	similarities	similarity	NNS
cord-306948-wkisfz1m	426	14	to	to	IN
cord-306948-wkisfz1m	426	15	both	both	CC
cord-306948-wkisfz1m	426	16	papain	papain	NN
cord-306948-wkisfz1m	426	17	-	-	HYPH
cord-306948-wkisfz1m	426	18	like	like	JJ
cord-306948-wkisfz1m	426	19	and	and	CC
cord-306948-wkisfz1m	426	20	chymotrypsin	chymotrypsin	JJ
cord-306948-wkisfz1m	426	21	-	-	HYPH
cord-306948-wkisfz1m	426	22	like	like	JJ
cord-306948-wkisfz1m	426	23	proteases	protease	NNS
cord-306948-wkisfz1m	426	24	RNA	RNA	NNP
cord-306948-wkisfz1m	426	25	-	-	HYPH
cord-306948-wkisfz1m	426	26	RNA	RNA	NNP
cord-306948-wkisfz1m	426	27	and	and	CC
cord-306948-wkisfz1m	426	28	RNA	RNA	NNP
cord-306948-wkisfz1m	426	29	-	-	HYPH
cord-306948-wkisfz1m	426	30	protein	protein	NN
cord-306948-wkisfz1m	426	31	interactions	interaction	NNS
cord-306948-wkisfz1m	426	32	in	in	IN
cord-306948-wkisfz1m	426	33	coronavirus	coronavirus	NN
cord-306948-wkisfz1m	426	34	replication	replication	NN
cord-306948-wkisfz1m	426	35	and	and	CC
cord-306948-wkisfz1m	426	36	transcription	transcription	NN
cord-306948-wkisfz1m	426	37	Nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	426	38	protein	protein	NN
cord-306948-wkisfz1m	426	39	1alpha	1alpha	CD
cord-306948-wkisfz1m	426	40	subunitbased	subunitbase	VBN
cord-306948-wkisfz1m	426	41	inhibition	inhibition	NN
cord-306948-wkisfz1m	426	42	of	of	IN
cord-306948-wkisfz1m	426	43	NF	NF	NNP
cord-306948-wkisfz1m	426	44	-	-	HYPH
cord-306948-wkisfz1m	426	45	kappaB	kappaB	NNP
cord-306948-wkisfz1m	426	46	activation	activation	NN
cord-306948-wkisfz1m	426	47	and	and	CC
cord-306948-wkisfz1m	426	48	suppression	suppression	NN
cord-306948-wkisfz1m	426	49	of	of	IN
cord-306948-wkisfz1m	426	50	interferon	interferon	NN
cord-306948-wkisfz1m	426	51	-	-	HYPH
cord-306948-wkisfz1m	426	52	beta	beta	NN
cord-306948-wkisfz1m	426	53	production	production	NN
cord-306948-wkisfz1m	426	54	by	by	IN
cord-306948-wkisfz1m	426	55	porcine	porcine	JJ
cord-306948-wkisfz1m	426	56	reproductive	reproductive	JJ
cord-306948-wkisfz1m	426	57	and	and	CC
cord-306948-wkisfz1m	426	58	respiratory	respiratory	JJ
cord-306948-wkisfz1m	426	59	syndrome	syndrome	NN
cord-306948-wkisfz1m	426	60	virus	virus	NN
cord-306948-wkisfz1m	426	61	RNA	RNA	NNP
cord-306948-wkisfz1m	426	62	transcripts	transcript	NNS
cord-306948-wkisfz1m	426	63	derived	derive	VBN
cord-306948-wkisfz1m	426	64	from	from	IN
cord-306948-wkisfz1m	426	65	a	a	DT
cord-306948-wkisfz1m	426	66	cloned	clone	VBN
cord-306948-wkisfz1m	426	67	full	full	JJ
cord-306948-wkisfz1m	426	68	-	-	HYPH
cord-306948-wkisfz1m	426	69	length	length	NN
cord-306948-wkisfz1m	426	70	copy	copy	NN
cord-306948-wkisfz1m	426	71	of	of	IN
cord-306948-wkisfz1m	426	72	the	the	DT
cord-306948-wkisfz1m	426	73	feline	feline	JJ
cord-306948-wkisfz1m	426	74	calicivirus	calicivirus	NNP
cord-306948-wkisfz1m	426	75	genome	genome	NN
cord-306948-wkisfz1m	426	76	do	do	VBP
cord-306948-wkisfz1m	426	77	not	not	RB
cord-306948-wkisfz1m	426	78	require	require	VB
cord-306948-wkisfz1m	426	79	VpG	vpg	NN
cord-306948-wkisfz1m	426	80	for	for	IN
cord-306948-wkisfz1m	426	81	infectivity	infectivity	NN
cord-306948-wkisfz1m	426	82	Cryo	cryo	NN
cord-306948-wkisfz1m	426	83	-	-	HYPH
cord-306948-wkisfz1m	426	84	electron	electron	NN
cord-306948-wkisfz1m	426	85	tomography	tomography	NN
cord-306948-wkisfz1m	426	86	of	of	IN
cord-306948-wkisfz1m	426	87	porcine	porcine	JJ
cord-306948-wkisfz1m	426	88	reproductive	reproductive	JJ
cord-306948-wkisfz1m	426	89	and	and	CC
cord-306948-wkisfz1m	426	90	respiratory	respiratory	JJ
cord-306948-wkisfz1m	426	91	syndrome	syndrome	NN
cord-306948-wkisfz1m	426	92	virus	virus	NN
cord-306948-wkisfz1m	426	93	:	:	:
cord-306948-wkisfz1m	426	94	organization	organization	NN
cord-306948-wkisfz1m	426	95	of	of	IN
cord-306948-wkisfz1m	426	96	the	the	DT
cord-306948-wkisfz1m	426	97	nucleocapsid	nucleocapsid	NNP
cord-306948-wkisfz1m	426	98	Amino	Amino	NNP
cord-306948-wkisfz1m	426	99	acid	acid	NN
cord-306948-wkisfz1m	426	100	residues	residue	NNS
cord-306948-wkisfz1m	426	101	in	in	IN
cord-306948-wkisfz1m	426	102	the	the	DT
cord-306948-wkisfz1m	426	103	non	non	JJ
cord-306948-wkisfz1m	426	104	-	-	JJ
cord-306948-wkisfz1m	426	105	structural	structural	JJ
cord-306948-wkisfz1m	426	106	protein	protein	NN
cord-306948-wkisfz1m	426	107	1	1	CD
cord-306948-wkisfz1m	426	108	of	of	IN
cord-306948-wkisfz1m	426	109	porcine	porcine	JJ
cord-306948-wkisfz1m	426	110	reproductive	reproductive	JJ
cord-306948-wkisfz1m	426	111	and	and	CC
cord-306948-wkisfz1m	426	112	respiratory	respiratory	JJ
cord-306948-wkisfz1m	426	113	syndrome	syndrome	NN
cord-306948-wkisfz1m	426	114	virus	virus	NN
cord-306948-wkisfz1m	426	115	involved	involve	VBN
cord-306948-wkisfz1m	426	116	in	in	IN
cord-306948-wkisfz1m	426	117	down	down	IN
cord-306948-wkisfz1m	426	118	-	-	HYPH
cord-306948-wkisfz1m	426	119	regulation	regulation	NN
cord-306948-wkisfz1m	426	120	of	of	IN
cord-306948-wkisfz1m	426	121	TNF	tnf	NN
cord-306948-wkisfz1m	426	122	-	-	HYPH
cord-306948-wkisfz1m	426	123	alpha	alpha	NN
cord-306948-wkisfz1m	426	124	expression	expression	NN
cord-306948-wkisfz1m	426	125	in	in	IN
cord-306948-wkisfz1m	426	126	vitro	vitro	FW
cord-306948-wkisfz1m	426	127	and	and	CC
cord-306948-wkisfz1m	426	128	attenuation	attenuation	NN
cord-306948-wkisfz1m	426	129	in	in	IN
cord-306948-wkisfz1m	426	130	vivo	vivo	NNP
cord-306948-wkisfz1m	426	131	Infectious	infectious	JJ
cord-306948-wkisfz1m	426	132	Japanese	japanese	JJ
cord-306948-wkisfz1m	426	133	encephalitis	encephalitis	NN
cord-306948-wkisfz1m	426	134	-	-	HYPH
cord-306948-wkisfz1m	426	135	virus	virus	NN
cord-306948-wkisfz1m	426	136	RNA	RNA	NNP
cord-306948-wkisfz1m	426	137	can	can	MD
cord-306948-wkisfz1m	426	138	be	be	VB
cord-306948-wkisfz1m	426	139	synthesized	synthesize	VBN
cord-306948-wkisfz1m	426	140	from	from	IN
cord-306948-wkisfz1m	426	141	in	in	IN
cord-306948-wkisfz1m	426	142	vitro	vitro	FW
cord-306948-wkisfz1m	426	143	-	-	HYPH
cord-306948-wkisfz1m	426	144	ligated	ligate	VBN
cord-306948-wkisfz1m	426	145	cDNA	cdna	NN
cord-306948-wkisfz1m	426	146	templates	template	NNS
cord-306948-wkisfz1m	426	147	Interplay	interplay	JJ
cord-306948-wkisfz1m	426	148	between	between	IN
cord-306948-wkisfz1m	426	149	interferon	interferon	NN
cord-306948-wkisfz1m	426	150	-	-	HYPH
cord-306948-wkisfz1m	426	151	mediated	mediate	VBN
cord-306948-wkisfz1m	426	152	innate	innate	JJ
cord-306948-wkisfz1m	426	153	immunity	immunity	NN
cord-306948-wkisfz1m	426	154	and	and	CC
cord-306948-wkisfz1m	426	155	porcine	porcine	JJ
cord-306948-wkisfz1m	426	156	reproductive	reproductive	JJ
cord-306948-wkisfz1m	426	157	and	and	CC
cord-306948-wkisfz1m	426	158	respiratory	respiratory	JJ
cord-306948-wkisfz1m	426	159	syndrome	syndrome	NN
cord-306948-wkisfz1m	426	160	virus	virus	NN
cord-306948-wkisfz1m	426	161	Crystal	Crystal	NNP
cord-306948-wkisfz1m	426	162	structure	structure	NN
cord-306948-wkisfz1m	426	163	of	of	IN
cord-306948-wkisfz1m	426	164	porcine	porcine	JJ
cord-306948-wkisfz1m	426	165	reproductive	reproductive	JJ
cord-306948-wkisfz1m	426	166	and	and	CC
cord-306948-wkisfz1m	426	167	respiratory	respiratory	JJ
cord-306948-wkisfz1m	426	168	syndrome	syndrome	NN
cord-306948-wkisfz1m	426	169	virus	virus	NN
cord-306948-wkisfz1m	426	170	leader	leader	NN
cord-306948-wkisfz1m	426	171	protease	protease	NN
cord-306948-wkisfz1m	426	172	nsp1-alpha	nsp1-alpha	NNP
cord-306948-wkisfz1m	427	1	The	the	DT
cord-306948-wkisfz1m	427	2	cysteine	cysteine	NN
cord-306948-wkisfz1m	427	3	protease	protease	NN
cord-306948-wkisfz1m	427	4	domain	domain	NN
cord-306948-wkisfz1m	427	5	of	of	IN
cord-306948-wkisfz1m	427	6	porcine	porcine	JJ
cord-306948-wkisfz1m	427	7	reproductive	reproductive	JJ
cord-306948-wkisfz1m	427	8	and	and	CC
cord-306948-wkisfz1m	427	9	respiratory	respiratory	JJ
cord-306948-wkisfz1m	427	10	syndrome	syndrome	NN
cord-306948-wkisfz1m	427	11	virus	virus	NN
cord-306948-wkisfz1m	427	12	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	427	13	protein	protein	NN
cord-306948-wkisfz1m	427	14	2	2	CD
cord-306948-wkisfz1m	427	15	possesses	possess	VBZ
cord-306948-wkisfz1m	427	16	deubiquitinating	deubiquitinating	NN
cord-306948-wkisfz1m	427	17	and	and	CC
cord-306948-wkisfz1m	427	18	interferon	interferon	NN
cord-306948-wkisfz1m	427	19	antagonism	antagonism	NN
cord-306948-wkisfz1m	427	20	functions	function	NNS
cord-306948-wkisfz1m	428	1	Nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	428	2	protein	protein	NN
cord-306948-wkisfz1m	428	3	2	2	CD
cord-306948-wkisfz1m	428	4	of	of	IN
cord-306948-wkisfz1m	428	5	porcine	porcine	JJ
cord-306948-wkisfz1m	428	6	reproductive	reproductive	JJ
cord-306948-wkisfz1m	428	7	and	and	CC
cord-306948-wkisfz1m	428	8	respiratory	respiratory	JJ
cord-306948-wkisfz1m	428	9	syndrome	syndrome	NN
cord-306948-wkisfz1m	428	10	virus	virus	NN
cord-306948-wkisfz1m	428	11	inhibits	inhibit	VBZ
cord-306948-wkisfz1m	428	12	the	the	DT
cord-306948-wkisfz1m	428	13	antiviral	antiviral	JJ
cord-306948-wkisfz1m	428	14	function	function	NN
cord-306948-wkisfz1m	428	15	of	of	IN
cord-306948-wkisfz1m	428	16	interferon	interferon	NN
cord-306948-wkisfz1m	428	17	-	-	HYPH
cord-306948-wkisfz1m	428	18	simulated	simulate	VBN
cord-306948-wkisfz1m	428	19	gene	gene	NN
cord-306948-wkisfz1m	428	20	15	15	CD
cord-306948-wkisfz1m	428	21	Identification	identification	NN
cord-306948-wkisfz1m	428	22	of	of	IN
cord-306948-wkisfz1m	428	23	dispensable	dispensable	JJ
cord-306948-wkisfz1m	428	24	nucleotide	nucleotide	JJ
cord-306948-wkisfz1m	428	25	sequence	sequence	NN
cord-306948-wkisfz1m	428	26	in	in	IN
cord-306948-wkisfz1m	428	27	3	3	CD
cord-306948-wkisfz1m	428	28	'	'	POS
cord-306948-wkisfz1m	428	29	untranslated	untranslated	JJ
cord-306948-wkisfz1m	428	30	region	region	NN
cord-306948-wkisfz1m	428	31	of	of	IN
cord-306948-wkisfz1m	428	32	porcine	porcine	JJ
cord-306948-wkisfz1m	428	33	reproductive	reproductive	JJ
cord-306948-wkisfz1m	428	34	and	and	CC
cord-306948-wkisfz1m	428	35	respiratory	respiratory	JJ
cord-306948-wkisfz1m	428	36	syndrome	syndrome	NN
cord-306948-wkisfz1m	428	37	virus	virus	NN
cord-306948-wkisfz1m	428	38	Identification	identification	NN
cord-306948-wkisfz1m	428	39	of	of	IN
cord-306948-wkisfz1m	428	40	non	non	JJ
cord-306948-wkisfz1m	428	41	-	-	JJ
cord-306948-wkisfz1m	428	42	essential	essential	JJ
cord-306948-wkisfz1m	428	43	regions	region	NNS
cord-306948-wkisfz1m	428	44	in	in	IN
cord-306948-wkisfz1m	428	45	nucleocapsid	nucleocapsid	NNP
cord-306948-wkisfz1m	428	46	protein	protein	NN
cord-306948-wkisfz1m	428	47	of	of	IN
cord-306948-wkisfz1m	428	48	porcine	porcine	JJ
cord-306948-wkisfz1m	428	49	reproductive	reproductive	JJ
cord-306948-wkisfz1m	428	50	and	and	CC
cord-306948-wkisfz1m	428	51	respiratory	respiratory	JJ
cord-306948-wkisfz1m	428	52	syndrome	syndrome	NN
cord-306948-wkisfz1m	428	53	virus	virus	NN
cord-306948-wkisfz1m	428	54	for	for	IN
cord-306948-wkisfz1m	428	55	replication	replication	NN
cord-306948-wkisfz1m	428	56	in	in	IN
cord-306948-wkisfz1m	428	57	cell	cell	NN
cord-306948-wkisfz1m	428	58	culture	culture	NN
cord-306948-wkisfz1m	429	1	Arterivirus	Arterivirus	NNP
cord-306948-wkisfz1m	429	2	minor	minor	JJ
cord-306948-wkisfz1m	429	3	envelope	envelope	NN
cord-306948-wkisfz1m	429	4	proteins	protein	NNS
cord-306948-wkisfz1m	429	5	are	be	VBP
cord-306948-wkisfz1m	429	6	a	a	DT
cord-306948-wkisfz1m	429	7	major	major	JJ
cord-306948-wkisfz1m	429	8	determinant	determinant	NN
cord-306948-wkisfz1m	429	9	of	of	IN
cord-306948-wkisfz1m	429	10	viral	viral	JJ
cord-306948-wkisfz1m	429	11	tropism	tropism	NN
cord-306948-wkisfz1m	429	12	in	in	IN
cord-306948-wkisfz1m	429	13	cell	cell	NN
cord-306948-wkisfz1m	429	14	culture	culture	NN
cord-306948-wkisfz1m	429	15	Chimeric	chimeric	JJ
cord-306948-wkisfz1m	429	16	porcine	porcine	JJ
cord-306948-wkisfz1m	429	17	reproductive	reproductive	JJ
cord-306948-wkisfz1m	429	18	and	and	CC
cord-306948-wkisfz1m	429	19	respiratory	respiratory	JJ
cord-306948-wkisfz1m	429	20	syndrome	syndrome	NN
cord-306948-wkisfz1m	429	21	viruses	virus	NNS
cord-306948-wkisfz1m	429	22	reveal	reveal	VBP
cord-306948-wkisfz1m	429	23	full	full	JJ
cord-306948-wkisfz1m	429	24	function	function	NN
cord-306948-wkisfz1m	429	25	of	of	IN
cord-306948-wkisfz1m	429	26	genotype	genotype	NN
cord-306948-wkisfz1m	429	27	1	1	CD
cord-306948-wkisfz1m	429	28	envelope	envelope	NN
cord-306948-wkisfz1m	429	29	proteins	protein	NNS
cord-306948-wkisfz1m	429	30	in	in	IN
cord-306948-wkisfz1m	429	31	the	the	DT
cord-306948-wkisfz1m	429	32	backbone	backbone	NN
cord-306948-wkisfz1m	429	33	of	of	IN
cord-306948-wkisfz1m	429	34	genotype	genotype	NN
cord-306948-wkisfz1m	429	35	2	2	CD
cord-306948-wkisfz1m	429	36	Emergence	emergence	NN
cord-306948-wkisfz1m	429	37	of	of	IN
cord-306948-wkisfz1m	429	38	fatal	fatal	JJ
cord-306948-wkisfz1m	429	39	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	429	40	variants	variant	NNS
cord-306948-wkisfz1m	429	41	:	:	:
cord-306948-wkisfz1m	429	42	Unparalleled	unparalleled	JJ
cord-306948-wkisfz1m	429	43	outbreaks	outbreak	NNS
cord-306948-wkisfz1m	429	44	of	of	IN
cord-306948-wkisfz1m	429	45	atypical	atypical	JJ
cord-306948-wkisfz1m	429	46	PRRS	PRRS	NNP
cord-306948-wkisfz1m	429	47	in	in	IN
cord-306948-wkisfz1m	429	48	China	China	NNP
cord-306948-wkisfz1m	429	49	and	and	CC
cord-306948-wkisfz1m	429	50	molecular	molecular	JJ
cord-306948-wkisfz1m	429	51	dissection	dissection	NN
cord-306948-wkisfz1m	429	52	of	of	IN
cord-306948-wkisfz1m	429	53	the	the	DT
cord-306948-wkisfz1m	429	54	unique	unique	JJ
cord-306948-wkisfz1m	429	55	hallmark	hallmark	NN
cord-306948-wkisfz1m	429	56	Arterivirus	Arterivirus	NNP
cord-306948-wkisfz1m	429	57	subgenomic	subgenomic	NNP
cord-306948-wkisfz1m	429	58	mRNA	mRNA	NNP
cord-306948-wkisfz1m	429	59	synthesis	synthesis	NN
cord-306948-wkisfz1m	429	60	and	and	CC
cord-306948-wkisfz1m	429	61	virion	virion	NN
cord-306948-wkisfz1m	429	62	biogenesis	biogenesis	NN
cord-306948-wkisfz1m	429	63	depend	depend	VBP
cord-306948-wkisfz1m	429	64	on	on	IN
cord-306948-wkisfz1m	429	65	the	the	DT
cord-306948-wkisfz1m	429	66	multifunctional	multifunctional	JJ
cord-306948-wkisfz1m	429	67	nsp1	nsp1	NNS
cord-306948-wkisfz1m	429	68	autoprotease	autoprotease	NNP
cord-306948-wkisfz1m	430	1	A	a	DT
cord-306948-wkisfz1m	430	2	zinc	zinc	NN
cord-306948-wkisfz1m	430	3	finger	finger	NN
cord-306948-wkisfz1m	430	4	-	-	HYPH
cord-306948-wkisfz1m	430	5	containing	contain	VBG
cord-306948-wkisfz1m	430	6	papain	papain	NN
cord-306948-wkisfz1m	430	7	-	-	HYPH
cord-306948-wkisfz1m	430	8	like	like	JJ
cord-306948-wkisfz1m	430	9	protease	protease	NN
cord-306948-wkisfz1m	430	10	couples	couple	NNS
cord-306948-wkisfz1m	430	11	subgenomic	subgenomic	NNP
cord-306948-wkisfz1m	430	12	mRNA	mRNA	NNP
cord-306948-wkisfz1m	430	13	synthesis	synthesis	NN
cord-306948-wkisfz1m	430	14	to	to	IN
cord-306948-wkisfz1m	430	15	genome	genome	NN
cord-306948-wkisfz1m	430	16	translation	translation	NN
cord-306948-wkisfz1m	430	17	in	in	IN
cord-306948-wkisfz1m	430	18	a	a	DT
cord-306948-wkisfz1m	430	19	positive	positive	JJ
cord-306948-wkisfz1m	430	20	-	-	HYPH
cord-306948-wkisfz1m	430	21	stranded	strand	VBN
cord-306948-wkisfz1m	430	22	RNA	RNA	NNP
cord-306948-wkisfz1m	430	23	virus	virus	NN
cord-306948-wkisfz1m	431	1	A	a	DT
cord-306948-wkisfz1m	431	2	highly	highly	RB
cord-306948-wkisfz1m	431	3	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	431	4	porcine	porcine	JJ
cord-306948-wkisfz1m	431	5	reproductive	reproductive	JJ
cord-306948-wkisfz1m	431	6	and	and	CC
cord-306948-wkisfz1m	431	7	respiratory	respiratory	JJ
cord-306948-wkisfz1m	431	8	syndrome	syndrome	NN
cord-306948-wkisfz1m	431	9	virus	virus	NN
cord-306948-wkisfz1m	431	10	generated	generate	VBN
cord-306948-wkisfz1m	431	11	from	from	IN
cord-306948-wkisfz1m	431	12	an	an	DT
cord-306948-wkisfz1m	431	13	infectious	infectious	JJ
cord-306948-wkisfz1m	431	14	cDNA	cdna	NN
cord-306948-wkisfz1m	431	15	clone	clone	NN
cord-306948-wkisfz1m	431	16	retains	retain	VBZ
cord-306948-wkisfz1m	431	17	the	the	DT
cord-306948-wkisfz1m	431	18	in	in	IN
cord-306948-wkisfz1m	431	19	vivo	vivo	NN
cord-306948-wkisfz1m	431	20	virulence	virulence	NN
cord-306948-wkisfz1m	431	21	and	and	CC
cord-306948-wkisfz1m	431	22	transmissibility	transmissibility	NN
cord-306948-wkisfz1m	431	23	properties	property	NNS
cord-306948-wkisfz1m	431	24	of	of	IN
cord-306948-wkisfz1m	431	25	the	the	DT
cord-306948-wkisfz1m	431	26	parental	parental	JJ
cord-306948-wkisfz1m	431	27	virus	virus	NN
cord-306948-wkisfz1m	431	28	Proteolytic	proteolytic	JJ
cord-306948-wkisfz1m	431	29	maturation	maturation	NN
cord-306948-wkisfz1m	431	30	of	of	IN
cord-306948-wkisfz1m	432	1	replicase	replicase	NNP
cord-306948-wkisfz1m	432	2	polyprotein	polyprotein	NNP
cord-306948-wkisfz1m	432	3	pp1a	pp1a	NNP
cord-306948-wkisfz1m	432	4	by	by	IN
cord-306948-wkisfz1m	432	5	the	the	DT
cord-306948-wkisfz1m	432	6	nsp4	nsp4	VBN
cord-306948-wkisfz1m	432	7	main	main	JJ
cord-306948-wkisfz1m	432	8	proteinase	proteinase	NN
cord-306948-wkisfz1m	432	9	is	be	VBZ
cord-306948-wkisfz1m	432	10	essential	essential	JJ
cord-306948-wkisfz1m	432	11	for	for	IN
cord-306948-wkisfz1m	432	12	equine	equine	JJ
cord-306948-wkisfz1m	432	13	arteritis	arteritis	NN
cord-306948-wkisfz1m	432	14	virus	virus	NN
cord-306948-wkisfz1m	432	15	replication	replication	NN
cord-306948-wkisfz1m	432	16	and	and	CC
cord-306948-wkisfz1m	432	17	includes	include	VBZ
cord-306948-wkisfz1m	432	18	internal	internal	JJ
cord-306948-wkisfz1m	432	19	cleavage	cleavage	NN
cord-306948-wkisfz1m	432	20	of	of	IN
cord-306948-wkisfz1m	432	21	nsp7	nsp7	NNP
cord-306948-wkisfz1m	432	22	Arterivirus	Arterivirus	NNP
cord-306948-wkisfz1m	432	23	and	and	CC
cord-306948-wkisfz1m	432	24	nirovirus	nirovirus	NNP
cord-306948-wkisfz1m	432	25	ovarian	ovarian	JJ
cord-306948-wkisfz1m	432	26	tumor	tumor	NN
cord-306948-wkisfz1m	432	27	domain	domain	NN
cord-306948-wkisfz1m	432	28	-	-	HYPH
cord-306948-wkisfz1m	432	29	containing	contain	VBG
cord-306948-wkisfz1m	432	30	deubiquitinases	deubiquitinase	NNS
cord-306948-wkisfz1m	432	31	target	target	NN
cord-306948-wkisfz1m	432	32	activated	activate	VBN
cord-306948-wkisfz1m	432	33	RIG	rig	NN
cord-306948-wkisfz1m	433	1	-I	-I	:
cord-306948-wkisfz1m	433	2	to	to	TO
cord-306948-wkisfz1m	433	3	control	control	VB
cord-306948-wkisfz1m	433	4	innate	innate	JJ
cord-306948-wkisfz1m	433	5	immune	immune	NN
cord-306948-wkisfz1m	433	6	signaling	signal	VBG
cord-306948-wkisfz1m	433	7	An	an	DT
cord-306948-wkisfz1m	433	8	infectious	infectious	JJ
cord-306948-wkisfz1m	433	9	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	433	10	cDNA	cdna	NN
cord-306948-wkisfz1m	433	11	clone	clone	NN
cord-306948-wkisfz1m	433	12	:	:	:
cord-306948-wkisfz1m	433	13	identification	identification	NN
cord-306948-wkisfz1m	433	14	of	of	IN
cord-306948-wkisfz1m	433	15	a	a	DT
cord-306948-wkisfz1m	433	16	replicase	replicase	NN
cord-306948-wkisfz1m	433	17	point	point	NN
cord-306948-wkisfz1m	433	18	mutation	mutation	NN
cord-306948-wkisfz1m	433	19	that	that	WDT
cord-306948-wkisfz1m	433	20	abolishes	abolish	VBZ
cord-306948-wkisfz1m	433	21	discontinuous	discontinuous	JJ
cord-306948-wkisfz1m	433	22	mRNA	mrna	NN
cord-306948-wkisfz1m	433	23	transcription	transcription	NN
cord-306948-wkisfz1m	433	24	Viable	viable	JJ
cord-306948-wkisfz1m	433	25	porcine	porcine	JJ
cord-306948-wkisfz1m	433	26	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	433	27	with	with	IN
cord-306948-wkisfz1m	433	28	deletions	deletion	NNS
cord-306948-wkisfz1m	433	29	proximal	proximal	JJ
cord-306948-wkisfz1m	433	30	to	to	IN
cord-306948-wkisfz1m	433	31	the	the	DT
cord-306948-wkisfz1m	433	32	3	3	CD
cord-306948-wkisfz1m	433	33	0	0	CD
cord-306948-wkisfz1m	433	34	end	end	NN
cord-306948-wkisfz1m	433	35	of	of	IN
cord-306948-wkisfz1m	433	36	the	the	DT
cord-306948-wkisfz1m	433	37	genome	genome	NN
cord-306948-wkisfz1m	433	38	Chimeric	chimeric	JJ
cord-306948-wkisfz1m	433	39	arteriviruses	arteriviruse	NNS
cord-306948-wkisfz1m	433	40	generated	generate	VBN
cord-306948-wkisfz1m	433	41	by	by	IN
cord-306948-wkisfz1m	433	42	swapping	swap	VBG
cord-306948-wkisfz1m	433	43	of	of	IN
cord-306948-wkisfz1m	434	1	the	the	DT
cord-306948-wkisfz1m	434	2	M	M	NNP
cord-306948-wkisfz1m	434	3	protein	protein	NN
cord-306948-wkisfz1m	434	4	ectodomain	ectodomain	NN
cord-306948-wkisfz1m	434	5	rule	rule	VBP
cord-306948-wkisfz1m	434	6	out	out	RP
cord-306948-wkisfz1m	434	7	a	a	DT
cord-306948-wkisfz1m	434	8	role	role	NN
cord-306948-wkisfz1m	434	9	of	of	IN
cord-306948-wkisfz1m	434	10	this	this	DT
cord-306948-wkisfz1m	434	11	domain	domain	NN
cord-306948-wkisfz1m	434	12	in	in	IN
cord-306948-wkisfz1m	434	13	viral	viral	JJ
cord-306948-wkisfz1m	434	14	targeting	target	VBG
cord-306948-wkisfz1m	434	15	Characterization	characterization	NN
cord-306948-wkisfz1m	434	16	of	of	IN
cord-306948-wkisfz1m	434	17	a	a	DT
cord-306948-wkisfz1m	434	18	serologic	serologic	JJ
cord-306948-wkisfz1m	434	19	marker	marker	NN
cord-306948-wkisfz1m	434	20	candidate	candidate	NN
cord-306948-wkisfz1m	434	21	for	for	IN
cord-306948-wkisfz1m	434	22	development	development	NN
cord-306948-wkisfz1m	434	23	of	of	IN
cord-306948-wkisfz1m	434	24	a	a	DT
cord-306948-wkisfz1m	434	25	live	live	RB
cord-306948-wkisfz1m	434	26	-	-	HYPH
cord-306948-wkisfz1m	434	27	attenuated	attenuated	JJ
cord-306948-wkisfz1m	434	28	DIVA	diva	NN
cord-306948-wkisfz1m	434	29	vaccine	vaccine	NN
cord-306948-wkisfz1m	434	30	against	against	IN
cord-306948-wkisfz1m	434	31	porcine	porcine	JJ
cord-306948-wkisfz1m	434	32	reproductive	reproductive	JJ
cord-306948-wkisfz1m	434	33	and	and	CC
cord-306948-wkisfz1m	434	34	respiratory	respiratory	JJ
cord-306948-wkisfz1m	434	35	syndrome	syndrome	NN
cord-306948-wkisfz1m	434	36	virus	virus	NN
cord-306948-wkisfz1m	434	37	Immune	immune	JJ
cord-306948-wkisfz1m	434	38	evasion	evasion	NN
cord-306948-wkisfz1m	434	39	of	of	IN
cord-306948-wkisfz1m	434	40	porcine	porcine	JJ
cord-306948-wkisfz1m	434	41	reproductive	reproductive	JJ
cord-306948-wkisfz1m	434	42	and	and	CC
cord-306948-wkisfz1m	434	43	respiratory	respiratory	JJ
cord-306948-wkisfz1m	434	44	syndrome	syndrome	NN
cord-306948-wkisfz1m	434	45	virus	virus	NN
cord-306948-wkisfz1m	434	46	through	through	IN
cord-306948-wkisfz1m	434	47	glycan	glycan	NN
cord-306948-wkisfz1m	434	48	shielding	shielding	NN
cord-306948-wkisfz1m	434	49	involves	involve	VBZ
cord-306948-wkisfz1m	434	50	both	both	CC
cord-306948-wkisfz1m	434	51	glycoprotein	glycoprotein	NN
cord-306948-wkisfz1m	434	52	5	5	CD
cord-306948-wkisfz1m	434	53	as	as	RB
cord-306948-wkisfz1m	434	54	well	well	RB
cord-306948-wkisfz1m	434	55	as	as	IN
cord-306948-wkisfz1m	434	56	glycoprotein	glycoprotein	NN
cord-306948-wkisfz1m	434	57	3	3	CD
cord-306948-wkisfz1m	434	58	N	n	CD
cord-306948-wkisfz1m	434	59	-	-	HYPH
cord-306948-wkisfz1m	434	60	Linked	link	VBN
cord-306948-wkisfz1m	434	61	glycosylation	glycosylation	NN
cord-306948-wkisfz1m	434	62	of	of	IN
cord-306948-wkisfz1m	434	63	GP5	GP5	NNS
cord-306948-wkisfz1m	434	64	of	of	IN
cord-306948-wkisfz1m	434	65	porcine	porcine	JJ
cord-306948-wkisfz1m	434	66	reproductive	reproductive	JJ
cord-306948-wkisfz1m	434	67	and	and	CC
cord-306948-wkisfz1m	434	68	respiratory	respiratory	JJ
cord-306948-wkisfz1m	434	69	syndrome	syndrome	NN
cord-306948-wkisfz1m	434	70	virus	virus	NN
cord-306948-wkisfz1m	434	71	is	be	VBZ
cord-306948-wkisfz1m	434	72	critically	critically	RB
cord-306948-wkisfz1m	434	73	important	important	JJ
cord-306948-wkisfz1m	434	74	for	for	IN
cord-306948-wkisfz1m	434	75	virus	virus	NN
cord-306948-wkisfz1m	434	76	replication	replication	NN
cord-306948-wkisfz1m	434	77	in	in	IN
cord-306948-wkisfz1m	434	78	vivo	vivo	NNP
cord-306948-wkisfz1m	434	79	Construction	construction	NN
cord-306948-wkisfz1m	434	80	and	and	CC
cord-306948-wkisfz1m	434	81	evaluation	evaluation	NN
cord-306948-wkisfz1m	434	82	of	of	IN
cord-306948-wkisfz1m	434	83	genetically	genetically	RB
cord-306948-wkisfz1m	434	84	engineered	engineer	VBN
cord-306948-wkisfz1m	434	85	replication	replication	NN
cord-306948-wkisfz1m	434	86	-	-	HYPH
cord-306948-wkisfz1m	434	87	defective	defective	JJ
cord-306948-wkisfz1m	434	88	porcine	porcine	JJ
cord-306948-wkisfz1m	434	89	reproductive	reproductive	JJ
cord-306948-wkisfz1m	434	90	and	and	CC
cord-306948-wkisfz1m	434	91	respiratory	respiratory	JJ
cord-306948-wkisfz1m	434	92	syndrome	syndrome	NN
cord-306948-wkisfz1m	434	93	virus	virus	NN
cord-306948-wkisfz1m	434	94	vaccine	vaccine	NN
cord-306948-wkisfz1m	434	95	candidates	candidate	NNS
cord-306948-wkisfz1m	434	96	Mystery	Mystery	VBG
cord-306948-wkisfz1m	434	97	swine	swine	NN
cord-306948-wkisfz1m	434	98	disease	disease	NN
cord-306948-wkisfz1m	434	99	in	in	IN
cord-306948-wkisfz1m	434	100	the	the	DT
cord-306948-wkisfz1m	434	101	Netherlands	Netherlands	NNP
cord-306948-wkisfz1m	435	1	-the	-the	DT
cord-306948-wkisfz1m	435	2	isolation	isolation	NN
cord-306948-wkisfz1m	435	3	of	of	IN
cord-306948-wkisfz1m	435	4	Lelystad	Lelystad	NNP
cord-306948-wkisfz1m	435	5	virus	virus	NN
cord-306948-wkisfz1m	435	6	Antigenic	antigenic	JJ
cord-306948-wkisfz1m	435	7	importance	importance	NN
cord-306948-wkisfz1m	435	8	of	of	IN
cord-306948-wkisfz1m	435	9	the	the	DT
cord-306948-wkisfz1m	435	10	carboxy	carboxy	JJ
cord-306948-wkisfz1m	435	11	-	-	HYPH
cord-306948-wkisfz1m	435	12	terminal	terminal	NN
cord-306948-wkisfz1m	435	13	beta	beta	NN
cord-306948-wkisfz1m	435	14	-	-	HYPH
cord-306948-wkisfz1m	435	15	strand	strand	NN
cord-306948-wkisfz1m	435	16	of	of	IN
cord-306948-wkisfz1m	435	17	the	the	DT
cord-306948-wkisfz1m	435	18	porcine	porcine	JJ
cord-306948-wkisfz1m	435	19	reproductive	reproductive	JJ
cord-306948-wkisfz1m	435	20	and	and	CC
cord-306948-wkisfz1m	435	21	respiratory	respiratory	JJ
cord-306948-wkisfz1m	435	22	syndrome	syndrome	NN
cord-306948-wkisfz1m	435	23	virus	virus	NN
cord-306948-wkisfz1m	435	24	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	435	25	protein	protein	NN
cord-306948-wkisfz1m	435	26	Full	full	JJ
cord-306948-wkisfz1m	435	27	-	-	HYPH
cord-306948-wkisfz1m	435	28	length	length	NN
cord-306948-wkisfz1m	435	29	sequence	sequence	NN
cord-306948-wkisfz1m	435	30	of	of	IN
cord-306948-wkisfz1m	435	31	a	a	DT
cord-306948-wkisfz1m	435	32	Canadian	canadian	JJ
cord-306948-wkisfz1m	435	33	porcine	porcine	JJ
cord-306948-wkisfz1m	435	34	reproductive	reproductive	NN
cord-306948-wkisfz1m	435	35	and	and	CC
cord-306948-wkisfz1m	435	36	respiratory	respiratory	JJ
cord-306948-wkisfz1m	435	37	syndrome	syndrome	NN
cord-306948-wkisfz1m	435	38	virus	virus	NN
cord-306948-wkisfz1m	435	39	(	(	-LRB-
cord-306948-wkisfz1m	435	40	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	435	41	)	)	-RRB-
cord-306948-wkisfz1m	435	42	isolate	isolate	VBP
cord-306948-wkisfz1m	435	43	Phosphorylation	Phosphorylation	NNP
cord-306948-wkisfz1m	435	44	of	of	IN
cord-306948-wkisfz1m	435	45	the	the	DT
cord-306948-wkisfz1m	435	46	porcine	porcine	JJ
cord-306948-wkisfz1m	435	47	reproductive	reproductive	JJ
cord-306948-wkisfz1m	435	48	and	and	CC
cord-306948-wkisfz1m	435	49	respiratory	respiratory	JJ
cord-306948-wkisfz1m	435	50	syndrome	syndrome	NN
cord-306948-wkisfz1m	435	51	virus	virus	NN
cord-306948-wkisfz1m	435	52	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	435	53	protein	protein	NN
cord-306948-wkisfz1m	435	54	Homo	Homo	NNP
cord-306948-wkisfz1m	435	55	-	-	HYPH
cord-306948-wkisfz1m	435	56	oligomerization	oligomerization	NN
cord-306948-wkisfz1m	435	57	of	of	IN
cord-306948-wkisfz1m	435	58	the	the	DT
cord-306948-wkisfz1m	435	59	porcine	porcine	JJ
cord-306948-wkisfz1m	435	60	reproductive	reproductive	JJ
cord-306948-wkisfz1m	435	61	and	and	CC
cord-306948-wkisfz1m	435	62	respiratory	respiratory	JJ
cord-306948-wkisfz1m	435	63	syndrome	syndrome	NN
cord-306948-wkisfz1m	435	64	virus	virus	NN
cord-306948-wkisfz1m	435	65	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	435	66	protein	protein	NNP
cord-306948-wkisfz1m	435	67	and	and	CC
cord-306948-wkisfz1m	435	68	the	the	DT
cord-306948-wkisfz1m	435	69	role	role	NN
cord-306948-wkisfz1m	435	70	of	of	IN
cord-306948-wkisfz1m	435	71	disulfide	disulfide	JJ
cord-306948-wkisfz1m	435	72	linkages	linkage	NNS
cord-306948-wkisfz1m	435	73	Stable	stable	JJ
cord-306948-wkisfz1m	435	74	expression	expression	NN
cord-306948-wkisfz1m	435	75	of	of	IN
cord-306948-wkisfz1m	435	76	foreign	foreign	JJ
cord-306948-wkisfz1m	435	77	gene	gene	NN
cord-306948-wkisfz1m	435	78	in	in	IN
cord-306948-wkisfz1m	435	79	nonessential	nonessential	JJ
cord-306948-wkisfz1m	435	80	region	region	NN
cord-306948-wkisfz1m	435	81	of	of	IN
cord-306948-wkisfz1m	435	82	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	435	83	protein	protein	NNP
cord-306948-wkisfz1m	435	84	2	2	CD
cord-306948-wkisfz1m	435	85	(	(	-LRB-
cord-306948-wkisfz1m	435	86	nsp2	nsp2	NN
cord-306948-wkisfz1m	435	87	)	)	-RRB-
cord-306948-wkisfz1m	435	88	of	of	IN
cord-306948-wkisfz1m	435	89	porcine	porcine	JJ
cord-306948-wkisfz1m	435	90	reproductive	reproductive	JJ
cord-306948-wkisfz1m	435	91	and	and	CC
cord-306948-wkisfz1m	435	92	respiratory	respiratory	JJ
cord-306948-wkisfz1m	435	93	syndrome	syndrome	NN
cord-306948-wkisfz1m	435	94	virus	virus	NN
cord-306948-wkisfz1m	435	95	:	:	:
cord-306948-wkisfz1m	435	96	applications	application	NNS
cord-306948-wkisfz1m	435	97	for	for	IN
cord-306948-wkisfz1m	435	98	marker	marker	NN
cord-306948-wkisfz1m	435	99	vaccine	vaccine	NN
cord-306948-wkisfz1m	435	100	design	design	NN
cord-306948-wkisfz1m	435	101	Identification	identification	NN
cord-306948-wkisfz1m	435	102	of	of	IN
cord-306948-wkisfz1m	435	103	nonessential	nonessential	JJ
cord-306948-wkisfz1m	435	104	regions	region	NNS
cord-306948-wkisfz1m	435	105	of	of	IN
cord-306948-wkisfz1m	435	106	the	the	DT
cord-306948-wkisfz1m	435	107	nsp2	nsp2	NNP
cord-306948-wkisfz1m	435	108	protein	protein	NN
cord-306948-wkisfz1m	435	109	of	of	IN
cord-306948-wkisfz1m	435	110	an	an	DT
cord-306948-wkisfz1m	435	111	attenuated	attenuated	JJ
cord-306948-wkisfz1m	435	112	vaccine	vaccine	NN
cord-306948-wkisfz1m	435	113	strain	strain	NN
cord-306948-wkisfz1m	435	114	(	(	-LRB-
cord-306948-wkisfz1m	435	115	HuN4-F112	HuN4-F112	NNP
cord-306948-wkisfz1m	435	116	)	)	-RRB-
cord-306948-wkisfz1m	435	117	of	of	IN
cord-306948-wkisfz1m	435	118	highly	highly	RB
cord-306948-wkisfz1m	435	119	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	435	120	porcine	porcine	JJ
cord-306948-wkisfz1m	435	121	reproductive	reproductive	JJ
cord-306948-wkisfz1m	435	122	and	and	CC
cord-306948-wkisfz1m	435	123	respiratory	respiratory	JJ
cord-306948-wkisfz1m	435	124	syndrome	syndrome	NN
cord-306948-wkisfz1m	435	125	virus	virus	NN
cord-306948-wkisfz1m	435	126	for	for	IN
cord-306948-wkisfz1m	435	127	replication	replication	NN
cord-306948-wkisfz1m	435	128	in	in	IN
cord-306948-wkisfz1m	435	129	marc-145	marc-145	CD
cord-306948-wkisfz1m	435	130	cell	cell	NN
cord-306948-wkisfz1m	436	1	The	the	DT
cord-306948-wkisfz1m	436	2	crystal	crystal	JJ
cord-306948-wkisfz1m	436	3	structure	structure	NN
cord-306948-wkisfz1m	436	4	of	of	IN
cord-306948-wkisfz1m	436	5	porcine	porcine	JJ
cord-306948-wkisfz1m	436	6	reproductive	reproductive	JJ
cord-306948-wkisfz1m	436	7	and	and	CC
cord-306948-wkisfz1m	436	8	respiratory	respiratory	JJ
cord-306948-wkisfz1m	436	9	syndrome	syndrome	NN
cord-306948-wkisfz1m	436	10	virus	virus	NN
cord-306948-wkisfz1m	436	11	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	436	12	protein	protein	NN
cord-306948-wkisfz1m	437	1	nsp1-beta	nsp1-beta	NNP
cord-306948-wkisfz1m	437	2	reveals	reveal	VBZ
cord-306948-wkisfz1m	437	3	a	a	DT
cord-306948-wkisfz1m	437	4	novel	novel	JJ
cord-306948-wkisfz1m	437	5	metal	metal	NN
cord-306948-wkisfz1m	437	6	-	-	HYPH
cord-306948-wkisfz1m	437	7	dependent	dependent	JJ
cord-306948-wkisfz1m	437	8	nuclease	nuclease	NN
cord-306948-wkisfz1m	437	9	Modulation	modulation	NN
cord-306948-wkisfz1m	437	10	of	of	IN
cord-306948-wkisfz1m	437	11	host	host	NN
cord-306948-wkisfz1m	437	12	cell	cell	NN
cord-306948-wkisfz1m	437	13	responses	response	NNS
cord-306948-wkisfz1m	437	14	and	and	CC
cord-306948-wkisfz1m	437	15	evasion	evasion	NN
cord-306948-wkisfz1m	437	16	strategies	strategy	NNS
cord-306948-wkisfz1m	437	17	for	for	IN
cord-306948-wkisfz1m	437	18	porcine	porcine	JJ
cord-306948-wkisfz1m	437	19	reproductive	reproductive	JJ
cord-306948-wkisfz1m	437	20	and	and	CC
cord-306948-wkisfz1m	437	21	respiratory	respiratory	JJ
cord-306948-wkisfz1m	437	22	syndrome	syndrome	NN
cord-306948-wkisfz1m	437	23	virus	virus	NN
cord-306948-wkisfz1m	437	24	Colocalization	colocalization	NN
cord-306948-wkisfz1m	437	25	and	and	CC
cord-306948-wkisfz1m	437	26	interaction	interaction	NN
cord-306948-wkisfz1m	437	27	of	of	IN
cord-306948-wkisfz1m	437	28	the	the	DT
cord-306948-wkisfz1m	437	29	porcine	porcine	JJ
cord-306948-wkisfz1m	437	30	arterivirus	arterivirus	NNP
cord-306948-wkisfz1m	437	31	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	437	32	protein	protein	NNP
cord-306948-wkisfz1m	437	33	with	with	IN
cord-306948-wkisfz1m	437	34	the	the	DT
cord-306948-wkisfz1m	437	35	small	small	JJ
cord-306948-wkisfz1m	437	36	nucleolar	nucleolar	JJ
cord-306948-wkisfz1m	437	37	RNA	RNA	NNP
cord-306948-wkisfz1m	437	38	-	-	HYPH
cord-306948-wkisfz1m	437	39	associated	associate	VBN
cord-306948-wkisfz1m	437	40	protein	protein	NN
cord-306948-wkisfz1m	437	41	fibrillarin	fibrillarin	NNP
cord-306948-wkisfz1m	437	42	Infectious	Infectious	NNP
cord-306948-wkisfz1m	437	43	cDNA	cdna	NN
cord-306948-wkisfz1m	437	44	clones	clone	NNS
cord-306948-wkisfz1m	437	45	of	of	IN
cord-306948-wkisfz1m	437	46	porcine	porcine	JJ
cord-306948-wkisfz1m	437	47	reproductive	reproductive	JJ
cord-306948-wkisfz1m	437	48	and	and	CC
cord-306948-wkisfz1m	437	49	respiratory	respiratory	JJ
cord-306948-wkisfz1m	437	50	syndrome	syndrome	NN
cord-306948-wkisfz1m	437	51	virus	virus	NN
cord-306948-wkisfz1m	437	52	and	and	CC
cord-306948-wkisfz1m	437	53	their	-PRON-	PRP$
cord-306948-wkisfz1m	437	54	potential	potential	NN
cord-306948-wkisfz1m	437	55	as	as	IN
cord-306948-wkisfz1m	437	56	vaccine	vaccine	NN
cord-306948-wkisfz1m	437	57	vectors	vector	NNS
cord-306948-wkisfz1m	437	58	Reverse	reverse	VBP
cord-306948-wkisfz1m	437	59	genetics	genetics	NN
cord-306948-wkisfz1m	437	60	with	with	IN
cord-306948-wkisfz1m	437	61	a	a	DT
cord-306948-wkisfz1m	437	62	full	full	JJ
cord-306948-wkisfz1m	437	63	-	-	HYPH
cord-306948-wkisfz1m	437	64	length	length	NN
cord-306948-wkisfz1m	437	65	infectious	infectious	JJ
cord-306948-wkisfz1m	437	66	cDNA	cdna	NN
cord-306948-wkisfz1m	437	67	of	of	IN
cord-306948-wkisfz1m	437	68	severe	severe	JJ
cord-306948-wkisfz1m	437	69	acute	acute	JJ
cord-306948-wkisfz1m	437	70	respiratory	respiratory	JJ
cord-306948-wkisfz1m	437	71	syndrome	syndrome	NN
cord-306948-wkisfz1m	437	72	coronavirus	coronavirus	NN
cord-306948-wkisfz1m	437	73	Reverse	reverse	VB
cord-306948-wkisfz1m	437	74	genetic	genetic	JJ
cord-306948-wkisfz1m	437	75	manipulation	manipulation	NN
cord-306948-wkisfz1m	437	76	of	of	IN
cord-306948-wkisfz1m	437	77	the	the	DT
cord-306948-wkisfz1m	437	78	overlapping	overlap	VBG
cord-306948-wkisfz1m	437	79	coding	code	VBG
cord-306948-wkisfz1m	437	80	regions	region	NNS
cord-306948-wkisfz1m	437	81	for	for	IN
cord-306948-wkisfz1m	437	82	structural	structural	JJ
cord-306948-wkisfz1m	437	83	proteins	protein	NNS
cord-306948-wkisfz1m	437	84	of	of	IN
cord-306948-wkisfz1m	437	85	the	the	DT
cord-306948-wkisfz1m	437	86	type	type	NN
cord-306948-wkisfz1m	437	87	II	II	NNP
cord-306948-wkisfz1m	437	88	porcine	porcine	JJ
cord-306948-wkisfz1m	437	89	reproductive	reproductive	JJ
cord-306948-wkisfz1m	437	90	and	and	CC
cord-306948-wkisfz1m	437	91	respiratory	respiratory	JJ
cord-306948-wkisfz1m	437	92	syndrome	syndrome	NN
cord-306948-wkisfz1m	437	93	virus	virus	NN
cord-306948-wkisfz1m	437	94	Construction	construction	NN
cord-306948-wkisfz1m	437	95	of	of	IN
cord-306948-wkisfz1m	437	96	infectious	infectious	JJ
cord-306948-wkisfz1m	437	97	cDNA	cdna	NN
cord-306948-wkisfz1m	437	98	clones	clone	NNS
cord-306948-wkisfz1m	437	99	of	of	IN
cord-306948-wkisfz1m	437	100	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	437	101	:	:	:
cord-306948-wkisfz1m	437	102	separation	separation	NN
cord-306948-wkisfz1m	437	103	of	of	IN
cord-306948-wkisfz1m	437	104	coding	code	VBG
cord-306948-wkisfz1m	437	105	regions	region	NNS
cord-306948-wkisfz1m	437	106	for	for	IN
cord-306948-wkisfz1m	437	107	nonstructural	nonstructural	JJ
cord-306948-wkisfz1m	437	108	and	and	CC
cord-306948-wkisfz1m	437	109	structural	structural	JJ
cord-306948-wkisfz1m	437	110	proteins	protein	NNS
cord-306948-wkisfz1m	438	1	Disulfide	disulfide	JJ
cord-306948-wkisfz1m	438	2	linkages	linkage	NNS
cord-306948-wkisfz1m	438	3	mediating	mediate	VBG
cord-306948-wkisfz1m	438	4	nucleocapsid	nucleocapsid	NN
cord-306948-wkisfz1m	438	5	protein	protein	NN
cord-306948-wkisfz1m	438	6	dimerization	dimerization	NN
cord-306948-wkisfz1m	438	7	are	be	VBP
cord-306948-wkisfz1m	438	8	not	not	RB
cord-306948-wkisfz1m	438	9	required	require	VBN
cord-306948-wkisfz1m	438	10	for	for	IN
cord-306948-wkisfz1m	438	11	porcine	porcine	JJ
cord-306948-wkisfz1m	438	12	arterivirus	arterivirus	NN
cord-306948-wkisfz1m	438	13	infectivity	infectivity	NN
cord-306948-wkisfz1m	438	14	Generation	Generation	NNP
cord-306948-wkisfz1m	438	15	of	of	IN
cord-306948-wkisfz1m	438	16	an	an	DT
cord-306948-wkisfz1m	438	17	infectious	infectious	JJ
cord-306948-wkisfz1m	438	18	clone	clone	NN
cord-306948-wkisfz1m	438	19	of	of	IN
cord-306948-wkisfz1m	438	20	HuN4-F112	HuN4-F112	NNP
cord-306948-wkisfz1m	438	21	,	,	,
cord-306948-wkisfz1m	438	22	an	an	DT
cord-306948-wkisfz1m	438	23	attenuated	attenuated	JJ
cord-306948-wkisfz1m	438	24	live	live	JJ
cord-306948-wkisfz1m	438	25	vaccine	vaccine	NN
cord-306948-wkisfz1m	438	26	strain	strain	NN
cord-306948-wkisfz1m	438	27	of	of	IN
cord-306948-wkisfz1m	438	28	porcine	porcine	JJ
cord-306948-wkisfz1m	438	29	reproductive	reproductive	JJ
cord-306948-wkisfz1m	438	30	and	and	CC
cord-306948-wkisfz1m	438	31	respiratory	respiratory	JJ
cord-306948-wkisfz1m	438	32	syndrome	syndrome	NN
cord-306948-wkisfz1m	438	33	virus	virus	NN
cord-306948-wkisfz1m	438	34	Broadening	broaden	VBG
cord-306948-wkisfz1m	438	35	the	the	DT
cord-306948-wkisfz1m	438	36	heterologous	heterologous	JJ
cord-306948-wkisfz1m	438	37	cross	cross	NN
cord-306948-wkisfz1m	438	38	-	-	JJ
cord-306948-wkisfz1m	438	39	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	438	40	antibody	antibody	NN
cord-306948-wkisfz1m	438	41	inducing	induce	VBG
cord-306948-wkisfz1m	438	42	ability	ability	NN
cord-306948-wkisfz1m	438	43	of	of	IN
cord-306948-wkisfz1m	438	44	porcine	porcine	JJ
cord-306948-wkisfz1m	438	45	reproductive	reproductive	JJ
cord-306948-wkisfz1m	438	46	and	and	CC
cord-306948-wkisfz1m	438	47	respiratory	respiratory	JJ
cord-306948-wkisfz1m	438	48	syndrome	syndrome	NN
cord-306948-wkisfz1m	438	49	virus	virus	NN
cord-306948-wkisfz1m	438	50	by	by	IN
cord-306948-wkisfz1m	438	51	breeding	breed	VBG
cord-306948-wkisfz1m	438	52	the	the	DT
cord-306948-wkisfz1m	438	53	GP4	GP4	NNP
cord-306948-wkisfz1m	438	54	or	or	CC
cord-306948-wkisfz1m	438	55	M	M	NNP
cord-306948-wkisfz1m	438	56	genes	gene	NNS
cord-306948-wkisfz1m	438	57	DNA	DNA	NNP
cord-306948-wkisfz1m	438	58	shuffling	shuffling	NN
cord-306948-wkisfz1m	438	59	of	of	IN
cord-306948-wkisfz1m	438	60	the	the	DT
cord-306948-wkisfz1m	438	61	GP3	GP3	NNP
cord-306948-wkisfz1m	438	62	genes	gene	NNS
cord-306948-wkisfz1m	438	63	of	of	IN
cord-306948-wkisfz1m	438	64	porcine	porcine	JJ
cord-306948-wkisfz1m	438	65	reproductive	reproductive	JJ
cord-306948-wkisfz1m	438	66	and	and	CC
cord-306948-wkisfz1m	438	67	respiratory	respiratory	JJ
cord-306948-wkisfz1m	438	68	syndrome	syndrome	NN
cord-306948-wkisfz1m	438	69	virus	virus	NN
cord-306948-wkisfz1m	438	70	(	(	-LRB-
cord-306948-wkisfz1m	438	71	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	438	72	)	)	-RRB-
cord-306948-wkisfz1m	439	1	produces	produce	VBZ
cord-306948-wkisfz1m	439	2	a	a	DT
cord-306948-wkisfz1m	439	3	chimeric	chimeric	JJ
cord-306948-wkisfz1m	439	4	virus	virus	NN
cord-306948-wkisfz1m	439	5	with	with	IN
cord-306948-wkisfz1m	439	6	an	an	DT
cord-306948-wkisfz1m	439	7	improved	improved	JJ
cord-306948-wkisfz1m	439	8	cross	cross	NN
cord-306948-wkisfz1m	439	9	-	-	JJ
cord-306948-wkisfz1m	439	10	neutralizing	neutralize	VBG
cord-306948-wkisfz1m	439	11	ability	ability	NN
cord-306948-wkisfz1m	439	12	against	against	IN
cord-306948-wkisfz1m	439	13	a	a	DT
cord-306948-wkisfz1m	439	14	heterologous	heterologous	JJ
cord-306948-wkisfz1m	439	15	PRRSV	PRRSV	NNP
cord-306948-wkisfz1m	439	16	strain	strain	VBP
cord-306948-wkisfz1m	439	17	The	the	DT
cord-306948-wkisfz1m	439	18	30-amino	30-amino	CD
cord-306948-wkisfz1m	439	19	-	-	HYPH
cord-306948-wkisfz1m	439	20	acid	acid	NN
cord-306948-wkisfz1m	439	21	deletion	deletion	NN
cord-306948-wkisfz1m	439	22	in	in	IN
cord-306948-wkisfz1m	439	23	the	the	DT
cord-306948-wkisfz1m	439	24	Nsp2	Nsp2	NNP
cord-306948-wkisfz1m	439	25	of	of	IN
cord-306948-wkisfz1m	439	26	highly	highly	RB
cord-306948-wkisfz1m	439	27	pathogenic	pathogenic	JJ
cord-306948-wkisfz1m	439	28	porcine	porcine	JJ
cord-306948-wkisfz1m	439	29	reproductive	reproductive	JJ
cord-306948-wkisfz1m	439	30	and	and	CC
cord-306948-wkisfz1m	439	31	respiratory	respiratory	JJ
cord-306948-wkisfz1m	439	32	syndrome	syndrome	NN
cord-306948-wkisfz1m	439	33	virus	virus	NN
cord-306948-wkisfz1m	439	34	emerging	emerge	VBG
cord-306948-wkisfz1m	439	35	in	in	IN
cord-306948-wkisfz1m	439	36	China	China	NNP
cord-306948-wkisfz1m	440	1	is	be	VBZ
cord-306948-wkisfz1m	440	2	not	not	RB
cord-306948-wkisfz1m	440	3	related	relate	VBN
cord-306948-wkisfz1m	440	4	to	to	IN
cord-306948-wkisfz1m	440	5	its	-PRON-	PRP$
cord-306948-wkisfz1m	440	6	virulence	virulence	NN
cord-306948-wkisfz1m	440	7	Virus	virus	NN
cord-306948-wkisfz1m	440	8	-	-	HYPH
cord-306948-wkisfz1m	440	9	encoded	encode	VBN
cord-306948-wkisfz1m	440	10	proteinases	proteinase	NNS
cord-306948-wkisfz1m	440	11	and	and	CC
cord-306948-wkisfz1m	440	12	proteolytic	proteolytic	JJ
cord-306948-wkisfz1m	440	13	processing	processing	NN
cord-306948-wkisfz1m	440	14	in	in	IN
cord-306948-wkisfz1m	440	15	the	the	DT
cord-306948-wkisfz1m	440	16	Nidovirales	Nidovirales	NNP