id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005941-e4fvj54l	Hamm, H.	The surfactant system of the adult lung: physiology and clinical perspectives	1992		.txt	text/plain	12897	644	38	Further clinical studies will be necessary to investigate the potential therapeutic benefits of surfactant substitution and the usefulness of pharmacologic manipulation of the secretory activity of alveolar type II cells in pulmonary medicine. The fate of secreted surfactant material seems to be determined by five mechanisms: -Intraalveolar catabolism -Phagocytosis and degradation by alveolar macrophages [110, 118] -Removal by the mucociliary escalator -Recycling into the alveolar type II cell -Redistribution into other surrounding tissue Clearance studies in rabbits [140] have shown that approximately 7% of radiolabeled phosphatidylcholine is removed via the upper airways in 24 h, suggesting that this pathway is only of minor importance. These studies may indicate that the acute effect of nitrogen dioxide on alveolar type II cells is enhanced surfactant lipid synthesis, while chronic low-dose exposure leads to a decrease in surfactant synthesis capacity. Effects of ozone on phospholipid synthesis by alveolar type II cells isolated from adult rat lung	./cache/cord-005941-e4fvj54l.txt	./txt/cord-005941-e4fvj54l.txt