id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022082-1dq623oe	Greaves, Peter	Respiratory Tract	2007-09-28		.txt	text/plain	19683	935	31	In the case of tulobuterol, a 32-adrenergic receptor agonist, it was argued that the nasal inflammation induced in rats in a one month inhalation toxicity study was the result of a particularly high exposure of the nasal epithelium to drug, not representative of the likely human exposure to tulobuterol by inhalation, where little or no nasal exposure would occur.^^ RP73401 [3cyclopentyloxy)-Ar-(3,5-dichloro-4-pyridy)-4-methoxybenzamide], a novel type IV phosphodiesterase inhibitor which was being developed for the treatment of asthma and rheumatoid arthritis, was also reported to produce degeneration of the olfactory epithelium in rats but neither dogs nor mice after single and repeated oral doses and by inhalation.^^ Histologically, the olfactory epithelium showed necrosis of the superflcial epithelial layers including the sustentacular and sensory cells, with sparing of the basal cell layer.	./cache/cord-022082-1dq623oe.txt	./txt/cord-022082-1dq623oe.txt