id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320959-sgdqhtns	Lee, Hanjun	Vitamin E Acetate as Linactant in the Pathophysiology of EVALI	2020-08-12		.txt	text/plain	6709	305	34	In membrane biophysics, Vitamin E is a linactant and a potent modulator of lateral phase separation that effectively reduces the line tension at the two-dimensional phase boundaries and thereby exponentially increases the surface viscosity of the pulmonary surfactant. Supplementation of pulmonary surfactants which retain moderate level of cholesterol and 10 controlled hypothermia for patients are recommended when the hypothesis that the line-active property of the vitamin derivative drives the pathogenesis of EVALI holds. Currently, there are 5 five established non-antioxidative properties of Vitamin E in the biological system: i) its ability to induce gel-liquid crystalline phase transition, ii) its active deposition in the lipid droplet of macrophages, iii) its modulation of the antidiabetic cascade involving diacylglycerol kinase (DGK) and protein kinase C (PKC), iv) its activation of the xenobiotic-sensing pregnane X receptor (PXR) signaling, and v) its ability to modulate lateral phase separation.	./cache/cord-320959-sgdqhtns.txt	./txt/cord-320959-sgdqhtns.txt