id sid tid token lemma pos cord-006608-mq4a4u40 1 1 key key NN cord-006608-mq4a4u40 1 2 : : : cord-006608-mq4a4u40 2 1 cord-006608-mq4a4u40 cord-006608-mq4a4u40 NNP cord-006608-mq4a4u40 2 2 authors author NNS cord-006608-mq4a4u40 2 3 : : : cord-006608-mq4a4u40 2 4 Fabbri Fabbri NNP cord-006608-mq4a4u40 2 5 , , , cord-006608-mq4a4u40 2 6 Marilyn Marilyn NNP cord-006608-mq4a4u40 2 7 ; ; : cord-006608-mq4a4u40 2 8 Maslow Maslow NNP cord-006608-mq4a4u40 2 9 , , , cord-006608-mq4a4u40 3 1 Melanie Melanie NNP cord-006608-mq4a4u40 3 2 J. J. NNP cord-006608-mq4a4u40 3 3 title title NN cord-006608-mq4a4u40 3 4 : : : cord-006608-mq4a4u40 4 1 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 4 2 pulmonary pulmonary JJ cord-006608-mq4a4u40 4 3 syndrome syndrome NN cord-006608-mq4a4u40 4 4 in in IN cord-006608-mq4a4u40 4 5 the the DT cord-006608-mq4a4u40 4 6 United United NNP cord-006608-mq4a4u40 4 7 States States NNP cord-006608-mq4a4u40 4 8 date date NN cord-006608-mq4a4u40 4 9 : : : cord-006608-mq4a4u40 5 1 2001 2001 CD cord-006608-mq4a4u40 5 2 journal journal NNP cord-006608-mq4a4u40 5 3 : : : cord-006608-mq4a4u40 6 1 Curr Curr NNP cord-006608-mq4a4u40 6 2 Infect infect VBP cord-006608-mq4a4u40 6 3 Dis Dis NNP cord-006608-mq4a4u40 6 4 Rep Rep NNP cord-006608-mq4a4u40 6 5 DOI doi NN cord-006608-mq4a4u40 6 6 : : : cord-006608-mq4a4u40 7 1 10.1007 10.1007 CD cord-006608-mq4a4u40 7 2 / / SYM cord-006608-mq4a4u40 7 3 s11908 s11908 NN cord-006608-mq4a4u40 7 4 - - HYPH cord-006608-mq4a4u40 7 5 001 001 CD cord-006608-mq4a4u40 7 6 - - HYPH cord-006608-mq4a4u40 7 7 0028 0028 CD cord-006608-mq4a4u40 7 8 - - SYM cord-006608-mq4a4u40 7 9 1 1 CD cord-006608-mq4a4u40 7 10 sha sha NNP cord-006608-mq4a4u40 7 11 : : : cord-006608-mq4a4u40 7 12 40084eb808d290e7927afcabcb04b1eaec4d4fd4 40084eb808d290e7927afcabcb04b1eaec4d4fd4 CD cord-006608-mq4a4u40 7 13 doc_id doc_id CD cord-006608-mq4a4u40 7 14 : : : cord-006608-mq4a4u40 7 15 6608 6608 CD cord-006608-mq4a4u40 7 16 cord_uid cord_uid NNS cord-006608-mq4a4u40 7 17 : : : cord-006608-mq4a4u40 8 1 mq4a4u40 mq4a4u40 `` cord-006608-mq4a4u40 8 2 Since since IN cord-006608-mq4a4u40 8 3 the the DT cord-006608-mq4a4u40 8 4 first first JJ cord-006608-mq4a4u40 8 5 outbreak outbreak NN cord-006608-mq4a4u40 8 6 of of IN cord-006608-mq4a4u40 8 7 hantavirus hantavirus NN cord-006608-mq4a4u40 8 8 pulmonary pulmonary JJ cord-006608-mq4a4u40 8 9 syndrome syndrome NN cord-006608-mq4a4u40 8 10 ( ( -LRB- cord-006608-mq4a4u40 8 11 HPS HPS NNP cord-006608-mq4a4u40 8 12 ) ) -RRB- cord-006608-mq4a4u40 8 13 in in IN cord-006608-mq4a4u40 8 14 1993 1993 CD cord-006608-mq4a4u40 8 15 , , , cord-006608-mq4a4u40 8 16 understanding understanding NN cord-006608-mq4a4u40 8 17 of of IN cord-006608-mq4a4u40 8 18 the the DT cord-006608-mq4a4u40 8 19 vast vast JJ cord-006608-mq4a4u40 8 20 distribution distribution NN cord-006608-mq4a4u40 8 21 and and CC cord-006608-mq4a4u40 8 22 potential potential JJ cord-006608-mq4a4u40 8 23 impact impact NN cord-006608-mq4a4u40 8 24 of of IN cord-006608-mq4a4u40 8 25 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 8 26 has have VBZ cord-006608-mq4a4u40 8 27 grown grow VBN cord-006608-mq4a4u40 8 28 . . . cord-006608-mq4a4u40 9 1 At at RB cord-006608-mq4a4u40 9 2 least least RBS cord-006608-mq4a4u40 9 3 277 277 CD cord-006608-mq4a4u40 9 4 cases case NNS cord-006608-mq4a4u40 9 5 of of IN cord-006608-mq4a4u40 9 6 HPS HPS NNP cord-006608-mq4a4u40 9 7 have have VBP cord-006608-mq4a4u40 9 8 been be VBN cord-006608-mq4a4u40 9 9 documented document VBN cord-006608-mq4a4u40 9 10 in in IN cord-006608-mq4a4u40 9 11 the the DT cord-006608-mq4a4u40 9 12 United United NNP cord-006608-mq4a4u40 9 13 States States NNP cord-006608-mq4a4u40 9 14 . . . cord-006608-mq4a4u40 10 1 The the DT cord-006608-mq4a4u40 10 2 full full JJ cord-006608-mq4a4u40 10 3 clinical clinical JJ cord-006608-mq4a4u40 10 4 spectrum spectrum NN cord-006608-mq4a4u40 10 5 has have VBZ cord-006608-mq4a4u40 10 6 yet yet RB cord-006608-mq4a4u40 10 7 to to TO cord-006608-mq4a4u40 10 8 be be VB cord-006608-mq4a4u40 10 9 elucidated elucidate VBN cord-006608-mq4a4u40 10 10 , , , cord-006608-mq4a4u40 10 11 and and CC cord-006608-mq4a4u40 10 12 one one CD cord-006608-mq4a4u40 10 13 outbreak outbreak NN cord-006608-mq4a4u40 10 14 suggested suggest VBD cord-006608-mq4a4u40 10 15 the the DT cord-006608-mq4a4u40 10 16 possibility possibility NN cord-006608-mq4a4u40 10 17 of of IN cord-006608-mq4a4u40 10 18 person person NN cord-006608-mq4a4u40 10 19 - - HYPH cord-006608-mq4a4u40 10 20 to to IN cord-006608-mq4a4u40 10 21 - - HYPH cord-006608-mq4a4u40 10 22 person person NN cord-006608-mq4a4u40 10 23 transmission transmission NN cord-006608-mq4a4u40 10 24 . . . cord-006608-mq4a4u40 11 1 New new JJ cord-006608-mq4a4u40 11 2 research research NN cord-006608-mq4a4u40 11 3 has have VBZ cord-006608-mq4a4u40 11 4 identified identify VBN cord-006608-mq4a4u40 11 5 the the DT cord-006608-mq4a4u40 11 6 β-3 β-3 NNP cord-006608-mq4a4u40 11 7 integrins integrin NNS cord-006608-mq4a4u40 11 8 as as IN cord-006608-mq4a4u40 11 9 cellular cellular JJ cord-006608-mq4a4u40 11 10 receptors receptor NNS cord-006608-mq4a4u40 11 11 for for IN cord-006608-mq4a4u40 11 12 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 11 13 and and CC cord-006608-mq4a4u40 11 14 has have VBZ cord-006608-mq4a4u40 11 15 determined determine VBN cord-006608-mq4a4u40 11 16 the the DT cord-006608-mq4a4u40 11 17 pivotal pivotal JJ cord-006608-mq4a4u40 11 18 role role NN cord-006608-mq4a4u40 11 19 of of IN cord-006608-mq4a4u40 11 20 the the DT cord-006608-mq4a4u40 11 21 immune immune JJ cord-006608-mq4a4u40 11 22 system system NN cord-006608-mq4a4u40 11 23 in in IN cord-006608-mq4a4u40 11 24 pathogenesis pathogenesis NN cord-006608-mq4a4u40 11 25 . . . cord-006608-mq4a4u40 12 1 Rapid rapid JJ cord-006608-mq4a4u40 12 2 diagnosis diagnosis NN cord-006608-mq4a4u40 12 3 has have VBZ cord-006608-mq4a4u40 12 4 been be VBN cord-006608-mq4a4u40 12 5 facilitated facilitate VBN cord-006608-mq4a4u40 12 6 by by IN cord-006608-mq4a4u40 12 7 a a DT cord-006608-mq4a4u40 12 8 new new JJ cord-006608-mq4a4u40 12 9 immunoblot immunoblot NNP cord-006608-mq4a4u40 12 10 assay assay NN cord-006608-mq4a4u40 12 11 to to TO cord-006608-mq4a4u40 12 12 detect detect VB cord-006608-mq4a4u40 12 13 Sin sin NN cord-006608-mq4a4u40 12 14 Nombre Nombre NNP cord-006608-mq4a4u40 12 15 virus virus NN cord-006608-mq4a4u40 12 16 infection infection NN cord-006608-mq4a4u40 12 17 . . . cord-006608-mq4a4u40 13 1 Treatment treatment NN cord-006608-mq4a4u40 13 2 remains remain VBZ cord-006608-mq4a4u40 13 3 primarily primarily RB cord-006608-mq4a4u40 13 4 supportive supportive JJ cord-006608-mq4a4u40 13 5 ; ; : cord-006608-mq4a4u40 13 6 however however RB cord-006608-mq4a4u40 13 7 , , , cord-006608-mq4a4u40 13 8 a a DT cord-006608-mq4a4u40 13 9 placebocontrolled placebocontrolled JJ cord-006608-mq4a4u40 13 10 trial trial NN cord-006608-mq4a4u40 13 11 of of IN cord-006608-mq4a4u40 13 12 ribavirin ribavirin NNP cord-006608-mq4a4u40 13 13 is be VBZ cord-006608-mq4a4u40 13 14 ongoing ongoing JJ cord-006608-mq4a4u40 13 15 . . . cord-006608-mq4a4u40 14 1 Extracorporeal extracorporeal JJ cord-006608-mq4a4u40 14 2 membrane membrane NN cord-006608-mq4a4u40 14 3 oxygenation oxygenation NN cord-006608-mq4a4u40 14 4 may may MD cord-006608-mq4a4u40 14 5 be be VB cord-006608-mq4a4u40 14 6 a a DT cord-006608-mq4a4u40 14 7 potential potential JJ cord-006608-mq4a4u40 14 8 therapy therapy NN cord-006608-mq4a4u40 14 9 in in IN cord-006608-mq4a4u40 14 10 severe severe JJ cord-006608-mq4a4u40 14 11 cases case NNS cord-006608-mq4a4u40 14 12 ; ; , cord-006608-mq4a4u40 14 13 inhaled inhale VBN cord-006608-mq4a4u40 14 14 nitric nitric NN cord-006608-mq4a4u40 14 15 oxide oxide NN cord-006608-mq4a4u40 14 16 needs need VBZ cord-006608-mq4a4u40 14 17 further further JJ cord-006608-mq4a4u40 14 18 study study NN cord-006608-mq4a4u40 14 19 . . . cord-006608-mq4a4u40 15 1 Vaccines vaccine NNS cord-006608-mq4a4u40 15 2 developed develop VBD cord-006608-mq4a4u40 15 3 against against IN cord-006608-mq4a4u40 15 4 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 15 5 associated associate VBN cord-006608-mq4a4u40 15 6 with with IN cord-006608-mq4a4u40 15 7 hemorrhagic hemorrhagic JJ cord-006608-mq4a4u40 15 8 fever fever NN cord-006608-mq4a4u40 15 9 and and CC cord-006608-mq4a4u40 15 10 renal renal JJ cord-006608-mq4a4u40 15 11 syndrome syndrome NN cord-006608-mq4a4u40 15 12 might may MD cord-006608-mq4a4u40 15 13 be be VB cord-006608-mq4a4u40 15 14 effective effective JJ cord-006608-mq4a4u40 15 15 against against IN cord-006608-mq4a4u40 15 16 HPS hps NN cord-006608-mq4a4u40 15 17 - - HYPH cord-006608-mq4a4u40 15 18 associated associate VBN cord-006608-mq4a4u40 15 19 strains strain NNS cord-006608-mq4a4u40 15 20 . . . cord-006608-mq4a4u40 16 1 An an DT cord-006608-mq4a4u40 16 2 outbreak outbreak NN cord-006608-mq4a4u40 16 3 of of IN cord-006608-mq4a4u40 16 4 an an DT cord-006608-mq4a4u40 16 5 acute acute JJ cord-006608-mq4a4u40 16 6 febrile febrile JJ cord-006608-mq4a4u40 16 7 illness illness NN cord-006608-mq4a4u40 16 8 characterized characterize VBN cord-006608-mq4a4u40 16 9 by by IN cord-006608-mq4a4u40 16 10 respiratory respiratory JJ cord-006608-mq4a4u40 16 11 failure failure NN cord-006608-mq4a4u40 16 12 , , , cord-006608-mq4a4u40 16 13 hypotension hypotension NN cord-006608-mq4a4u40 16 14 , , , cord-006608-mq4a4u40 16 15 and and CC cord-006608-mq4a4u40 16 16 shock shock NN cord-006608-mq4a4u40 16 17 was be VBD cord-006608-mq4a4u40 16 18 reported report VBN cord-006608-mq4a4u40 16 19 by by IN cord-006608-mq4a4u40 16 20 physicians physician NNS cord-006608-mq4a4u40 16 21 in in IN cord-006608-mq4a4u40 16 22 the the DT cord-006608-mq4a4u40 16 23 Four Four NNP cord-006608-mq4a4u40 16 24 Corners Corners NNPS cord-006608-mq4a4u40 16 25 region region NN cord-006608-mq4a4u40 16 26 of of IN cord-006608-mq4a4u40 16 27 the the DT cord-006608-mq4a4u40 16 28 United United NNP cord-006608-mq4a4u40 16 29 States States NNP cord-006608-mq4a4u40 16 30 in in IN cord-006608-mq4a4u40 16 31 May May NNP cord-006608-mq4a4u40 16 32 1993 1993 CD cord-006608-mq4a4u40 16 33 . . . cord-006608-mq4a4u40 17 1 A a DT cord-006608-mq4a4u40 17 2 previously previously RB cord-006608-mq4a4u40 17 3 unknown unknown JJ cord-006608-mq4a4u40 17 4 hantavirus hantavirus NN cord-006608-mq4a4u40 17 5 was be VBD cord-006608-mq4a4u40 17 6 subsequently subsequently RB cord-006608-mq4a4u40 17 7 identified identify VBN cord-006608-mq4a4u40 17 8 as as IN cord-006608-mq4a4u40 17 9 the the DT cord-006608-mq4a4u40 17 10 cause cause NN cord-006608-mq4a4u40 17 11 [ [ -LRB- cord-006608-mq4a4u40 17 12 1 1 CD cord-006608-mq4a4u40 17 13 ] ] -RRB- cord-006608-mq4a4u40 17 14 . . . cord-006608-mq4a4u40 18 1 Unlike unlike IN cord-006608-mq4a4u40 18 2 the the DT cord-006608-mq4a4u40 18 3 previously previously RB cord-006608-mq4a4u40 18 4 characterized characterize VBN cord-006608-mq4a4u40 18 5 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 18 6 , , , cord-006608-mq4a4u40 18 7 which which WDT cord-006608-mq4a4u40 18 8 cause cause VBP cord-006608-mq4a4u40 18 9 fever fever NN cord-006608-mq4a4u40 18 10 , , , cord-006608-mq4a4u40 18 11 hemorrhagic hemorrhagic JJ cord-006608-mq4a4u40 18 12 manifestations manifestation NNS cord-006608-mq4a4u40 18 13 , , , cord-006608-mq4a4u40 18 14 and and CC cord-006608-mq4a4u40 18 15 acute acute JJ cord-006608-mq4a4u40 18 16 renal renal JJ cord-006608-mq4a4u40 18 17 failure failure NN cord-006608-mq4a4u40 18 18 ( ( -LRB- cord-006608-mq4a4u40 18 19 hemorrhagic hemorrhagic JJ cord-006608-mq4a4u40 18 20 fever fever NN cord-006608-mq4a4u40 18 21 with with IN cord-006608-mq4a4u40 18 22 renal renal JJ cord-006608-mq4a4u40 18 23 syndrome syndrome NN cord-006608-mq4a4u40 18 24 ) ) -RRB- cord-006608-mq4a4u40 18 25 , , , cord-006608-mq4a4u40 18 26 the the DT cord-006608-mq4a4u40 18 27 newly newly RB cord-006608-mq4a4u40 18 28 named name VBN cord-006608-mq4a4u40 18 29 hantavirus hantavirus NN cord-006608-mq4a4u40 18 30 pulmonary pulmonary JJ cord-006608-mq4a4u40 18 31 syndrome syndrome NN cord-006608-mq4a4u40 18 32 ( ( -LRB- cord-006608-mq4a4u40 18 33 HPS HPS NNP cord-006608-mq4a4u40 18 34 ) ) -RRB- cord-006608-mq4a4u40 18 35 presented present VBN cord-006608-mq4a4u40 18 36 with with IN cord-006608-mq4a4u40 18 37 a a DT cord-006608-mq4a4u40 18 38 brief brief JJ cord-006608-mq4a4u40 18 39 prodromal prodromal JJ cord-006608-mq4a4u40 18 40 illness illness NN cord-006608-mq4a4u40 18 41 followed follow VBN cord-006608-mq4a4u40 18 42 by by IN cord-006608-mq4a4u40 18 43 rapidly rapidly RB cord-006608-mq4a4u40 18 44 progressive progressive JJ cord-006608-mq4a4u40 18 45 noncardiogenic noncardiogenic JJ cord-006608-mq4a4u40 18 46 pulmonary pulmonary JJ cord-006608-mq4a4u40 18 47 edema edema NN cord-006608-mq4a4u40 18 48 [ [ -LRB- cord-006608-mq4a4u40 18 49 2 2 CD cord-006608-mq4a4u40 18 50 ] ] -RRB- cord-006608-mq4a4u40 18 51 . . . cord-006608-mq4a4u40 19 1 The the DT cord-006608-mq4a4u40 19 2 earliest early RBS cord-006608-mq4a4u40 19 3 known know VBN cord-006608-mq4a4u40 19 4 case case NN cord-006608-mq4a4u40 19 5 of of IN cord-006608-mq4a4u40 19 6 HPS hps NN cord-006608-mq4a4u40 19 7 to to TO cord-006608-mq4a4u40 19 8 be be VB cord-006608-mq4a4u40 19 9 confirmed confirm VBN cord-006608-mq4a4u40 19 10 by by IN cord-006608-mq4a4u40 19 11 serology serology NN cord-006608-mq4a4u40 19 12 occurred occur VBD cord-006608-mq4a4u40 19 13 in in IN cord-006608-mq4a4u40 19 14 Utah Utah NNP cord-006608-mq4a4u40 19 15 in in IN cord-006608-mq4a4u40 19 16 1959 1959 CD cord-006608-mq4a4u40 19 17 [ [ -LRB- cord-006608-mq4a4u40 19 18 3 3 CD cord-006608-mq4a4u40 19 19 ] ] -RRB- cord-006608-mq4a4u40 19 20 . . . cord-006608-mq4a4u40 20 1 The the DT cord-006608-mq4a4u40 20 2 mortality mortality NN cord-006608-mq4a4u40 20 3 rate rate NN cord-006608-mq4a4u40 20 4 associated associate VBN cord-006608-mq4a4u40 20 5 with with IN cord-006608-mq4a4u40 20 6 HPS HPS NNP cord-006608-mq4a4u40 20 7 is be VBZ cord-006608-mq4a4u40 20 8 40 40 CD cord-006608-mq4a4u40 20 9 % % NN cord-006608-mq4a4u40 20 10 to to TO cord-006608-mq4a4u40 20 11 60 60 CD cord-006608-mq4a4u40 20 12 % % NN cord-006608-mq4a4u40 20 13 , , , cord-006608-mq4a4u40 20 14 although although IN cord-006608-mq4a4u40 20 15 mild mild JJ cord-006608-mq4a4u40 20 16 and and CC cord-006608-mq4a4u40 20 17 even even RB cord-006608-mq4a4u40 20 18 asymptomatic asymptomatic JJ cord-006608-mq4a4u40 20 19 cases case NNS cord-006608-mq4a4u40 20 20 are be VBP cord-006608-mq4a4u40 20 21 now now RB cord-006608-mq4a4u40 20 22 recognized recognize VBN cord-006608-mq4a4u40 20 23 . . . cord-006608-mq4a4u40 21 1 In in IN cord-006608-mq4a4u40 21 2 the the DT cord-006608-mq4a4u40 21 3 United United NNP cord-006608-mq4a4u40 21 4 States States NNP cord-006608-mq4a4u40 21 5 , , , cord-006608-mq4a4u40 21 6 HPS HPS NNP cord-006608-mq4a4u40 21 7 is be VBZ cord-006608-mq4a4u40 21 8 caused cause VBN cord-006608-mq4a4u40 21 9 by by IN cord-006608-mq4a4u40 21 10 at at RB cord-006608-mq4a4u40 21 11 least least RBS cord-006608-mq4a4u40 21 12 four four CD cord-006608-mq4a4u40 21 13 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 21 14 : : : cord-006608-mq4a4u40 21 15 the the DT cord-006608-mq4a4u40 21 16 Sin Sin NNP cord-006608-mq4a4u40 21 17 Nombre Nombre NNP cord-006608-mq4a4u40 21 18 virus virus NN cord-006608-mq4a4u40 21 19 ( ( -LRB- cord-006608-mq4a4u40 21 20 SNV SNV NNP cord-006608-mq4a4u40 21 21 , , , cord-006608-mq4a4u40 21 22 responsible responsible JJ cord-006608-mq4a4u40 21 23 for for IN cord-006608-mq4a4u40 21 24 the the DT cord-006608-mq4a4u40 21 25 Four Four NNP cord-006608-mq4a4u40 21 26 Corners Corners NNPS cord-006608-mq4a4u40 21 27 outbreak outbreak NN cord-006608-mq4a4u40 21 28 ) ) -RRB- cord-006608-mq4a4u40 21 29 , , , cord-006608-mq4a4u40 21 30 the the DT cord-006608-mq4a4u40 21 31 Black Black NNP cord-006608-mq4a4u40 21 32 Creek Creek NNP cord-006608-mq4a4u40 21 33 Canal Canal NNP cord-006608-mq4a4u40 21 34 virus virus NN cord-006608-mq4a4u40 21 35 ( ( -LRB- cord-006608-mq4a4u40 21 36 isolated isolate VBN cord-006608-mq4a4u40 21 37 from from IN cord-006608-mq4a4u40 21 38 the the DT cord-006608-mq4a4u40 21 39 Florida Florida NNP cord-006608-mq4a4u40 21 40 cotton cotton NN cord-006608-mq4a4u40 21 41 rat rat NN cord-006608-mq4a4u40 21 42 ) ) -RRB- cord-006608-mq4a4u40 22 1 [ [ -LRB- cord-006608-mq4a4u40 22 2 4 4 CD cord-006608-mq4a4u40 22 3 ] ] -RRB- cord-006608-mq4a4u40 22 4 , , , cord-006608-mq4a4u40 22 5 the the DT cord-006608-mq4a4u40 22 6 Bayou Bayou NNP cord-006608-mq4a4u40 22 7 virus virus NN cord-006608-mq4a4u40 22 8 in in IN cord-006608-mq4a4u40 22 9 Louisiana Louisiana NNP cord-006608-mq4a4u40 22 10 [ [ -LRB- cord-006608-mq4a4u40 22 11 5 5 CD cord-006608-mq4a4u40 22 12 ] ] -RRB- cord-006608-mq4a4u40 22 13 , , , cord-006608-mq4a4u40 22 14 and and CC cord-006608-mq4a4u40 22 15 the the DT cord-006608-mq4a4u40 22 16 New New NNP cord-006608-mq4a4u40 22 17 York York NNP cord-006608-mq4a4u40 22 18 1 1 CD cord-006608-mq4a4u40 22 19 hantavirus hantavirus NN cord-006608-mq4a4u40 22 20 [ [ -LRB- cord-006608-mq4a4u40 22 21 6 6 CD cord-006608-mq4a4u40 22 22 ] ] -RRB- cord-006608-mq4a4u40 22 23 . . . cord-006608-mq4a4u40 23 1 Several several JJ cord-006608-mq4a4u40 23 2 other other JJ cord-006608-mq4a4u40 23 3 closely closely RB cord-006608-mq4a4u40 23 4 related related JJ cord-006608-mq4a4u40 23 5 viruses virus NNS cord-006608-mq4a4u40 23 6 have have VBP cord-006608-mq4a4u40 23 7 been be VBN cord-006608-mq4a4u40 23 8 identified identify VBN cord-006608-mq4a4u40 23 9 in in IN cord-006608-mq4a4u40 23 10 Canada Canada NNP cord-006608-mq4a4u40 23 11 and and CC cord-006608-mq4a4u40 23 12 South South NNP cord-006608-mq4a4u40 23 13 America America NNP cord-006608-mq4a4u40 23 14 . . . cord-006608-mq4a4u40 24 1 An an DT cord-006608-mq4a4u40 24 2 estimated estimated JJ cord-006608-mq4a4u40 24 3 1000 1000 CD cord-006608-mq4a4u40 24 4 to to TO cord-006608-mq4a4u40 24 5 2000 2000 CD cord-006608-mq4a4u40 24 6 cases case NNS cord-006608-mq4a4u40 24 7 of of IN cord-006608-mq4a4u40 24 8 hantaviral hantaviral JJ cord-006608-mq4a4u40 24 9 infections infection NNS cord-006608-mq4a4u40 24 10 occur occur VBP cord-006608-mq4a4u40 24 11 each each DT cord-006608-mq4a4u40 24 12 year year NN cord-006608-mq4a4u40 24 13 worldwide worldwide RB cord-006608-mq4a4u40 24 14 . . . cord-006608-mq4a4u40 25 1 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 25 2 pulmonary pulmonary JJ cord-006608-mq4a4u40 25 3 syndrome syndrome NN cord-006608-mq4a4u40 25 4 is be VBZ cord-006608-mq4a4u40 25 5 a a DT cord-006608-mq4a4u40 25 6 febrile febrile JJ cord-006608-mq4a4u40 25 7 illness illness NN cord-006608-mq4a4u40 25 8 characterized characterize VBN cord-006608-mq4a4u40 25 9 by by IN cord-006608-mq4a4u40 25 10 bilateral bilateral JJ cord-006608-mq4a4u40 25 11 diffuse diffuse JJ cord-006608-mq4a4u40 25 12 interstitial interstitial JJ cord-006608-mq4a4u40 25 13 edema edema NN cord-006608-mq4a4u40 25 14 on on IN cord-006608-mq4a4u40 25 15 chest chest NN cord-006608-mq4a4u40 25 16 radiography radiography NN cord-006608-mq4a4u40 25 17 in in IN cord-006608-mq4a4u40 25 18 a a DT cord-006608-mq4a4u40 25 19 previously previously RB cord-006608-mq4a4u40 25 20 healthy healthy JJ cord-006608-mq4a4u40 25 21 person person NN cord-006608-mq4a4u40 25 22 ; ; : cord-006608-mq4a4u40 25 23 respiratory respiratory JJ cord-006608-mq4a4u40 25 24 compromise compromise NN cord-006608-mq4a4u40 25 25 develops develop VBZ cord-006608-mq4a4u40 25 26 within within IN cord-006608-mq4a4u40 25 27 72 72 CD cord-006608-mq4a4u40 25 28 hours hour NNS cord-006608-mq4a4u40 25 29 of of IN cord-006608-mq4a4u40 25 30 hospitalization hospitalization NN cord-006608-mq4a4u40 25 31 . . . cord-006608-mq4a4u40 26 1 The the DT cord-006608-mq4a4u40 26 2 syndrome syndrome NN cord-006608-mq4a4u40 26 3 should should MD cord-006608-mq4a4u40 26 4 be be VB cord-006608-mq4a4u40 26 5 suspected suspect VBN cord-006608-mq4a4u40 26 6 in in IN cord-006608-mq4a4u40 26 7 cases case NNS cord-006608-mq4a4u40 26 8 of of IN cord-006608-mq4a4u40 26 9 unexplained unexplained JJ cord-006608-mq4a4u40 26 10 fatal fatal JJ cord-006608-mq4a4u40 26 11 respiratory respiratory JJ cord-006608-mq4a4u40 26 12 illness illness NN cord-006608-mq4a4u40 26 13 in in IN cord-006608-mq4a4u40 26 14 which which WDT cord-006608-mq4a4u40 26 15 autopsy autopsy JJ cord-006608-mq4a4u40 26 16 examination examination NN cord-006608-mq4a4u40 26 17 shows show VBZ cord-006608-mq4a4u40 26 18 noncardiogenic noncardiogenic JJ cord-006608-mq4a4u40 26 19 pulmonary pulmonary JJ cord-006608-mq4a4u40 26 20 edema edema NN cord-006608-mq4a4u40 26 21 without without IN cord-006608-mq4a4u40 26 22 an an DT cord-006608-mq4a4u40 26 23 identifiable identifiable JJ cord-006608-mq4a4u40 26 24 cause cause NN cord-006608-mq4a4u40 26 25 . . . cord-006608-mq4a4u40 27 1 Clinical clinical JJ cord-006608-mq4a4u40 27 2 suspicion suspicion NN cord-006608-mq4a4u40 27 3 is be VBZ cord-006608-mq4a4u40 27 4 confirmed confirm VBN cord-006608-mq4a4u40 27 5 with with IN cord-006608-mq4a4u40 27 6 serology serology NN cord-006608-mq4a4u40 27 7 , , , cord-006608-mq4a4u40 27 8 detection detection NN cord-006608-mq4a4u40 27 9 of of IN cord-006608-mq4a4u40 27 10 hantaviralspecific hantaviralspecific NNP cord-006608-mq4a4u40 27 11 RNA RNA NNP cord-006608-mq4a4u40 27 12 by by IN cord-006608-mq4a4u40 27 13 polymerase polymerase NN cord-006608-mq4a4u40 27 14 chain chain NN cord-006608-mq4a4u40 27 15 reaction reaction NN cord-006608-mq4a4u40 27 16 , , , cord-006608-mq4a4u40 27 17 or or CC cord-006608-mq4a4u40 27 18 detection detection NN cord-006608-mq4a4u40 27 19 of of IN cord-006608-mq4a4u40 27 20 hantaviral hantaviral JJ cord-006608-mq4a4u40 27 21 antigen antigen NN cord-006608-mq4a4u40 27 22 by by IN cord-006608-mq4a4u40 27 23 immunohistochemical immunohistochemical JJ cord-006608-mq4a4u40 27 24 testing testing NN cord-006608-mq4a4u40 27 25 of of IN cord-006608-mq4a4u40 27 26 clinical clinical JJ cord-006608-mq4a4u40 27 27 specimens specimen NNS cord-006608-mq4a4u40 27 28 ( ( -LRB- cord-006608-mq4a4u40 27 29 Table table NN cord-006608-mq4a4u40 27 30 1 1 CD cord-006608-mq4a4u40 27 31 ) ) -RRB- cord-006608-mq4a4u40 27 32 . . . cord-006608-mq4a4u40 28 1 Hantaviruses Hantaviruses NNP cord-006608-mq4a4u40 28 2 are be VBP cord-006608-mq4a4u40 28 3 lipid lipid NN cord-006608-mq4a4u40 28 4 - - HYPH cord-006608-mq4a4u40 28 5 enveloped envelop VBN cord-006608-mq4a4u40 28 6 , , , cord-006608-mq4a4u40 28 7 tri tri JJ cord-006608-mq4a4u40 28 8 - - JJ cord-006608-mq4a4u40 28 9 segmented segmented JJ cord-006608-mq4a4u40 28 10 , , , cord-006608-mq4a4u40 28 11 negativesense negativesense NNP cord-006608-mq4a4u40 28 12 RNA RNA NNP cord-006608-mq4a4u40 28 13 viruses virus NNS cord-006608-mq4a4u40 28 14 belonging belong VBG cord-006608-mq4a4u40 28 15 to to IN cord-006608-mq4a4u40 28 16 the the DT cord-006608-mq4a4u40 28 17 Bunyavirus Bunyavirus NNP cord-006608-mq4a4u40 28 18 family family NN cord-006608-mq4a4u40 28 19 . . . cord-006608-mq4a4u40 29 1 The the DT cord-006608-mq4a4u40 29 2 genus genus NN cord-006608-mq4a4u40 29 3 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 29 4 was be VBD cord-006608-mq4a4u40 29 5 named name VBN cord-006608-mq4a4u40 29 6 for for IN cord-006608-mq4a4u40 29 7 the the DT cord-006608-mq4a4u40 29 8 first first JJ cord-006608-mq4a4u40 29 9 virus virus NN cord-006608-mq4a4u40 29 10 isolated isolate VBN cord-006608-mq4a4u40 29 11 in in IN cord-006608-mq4a4u40 29 12 1976 1976 CD cord-006608-mq4a4u40 29 13 from from IN cord-006608-mq4a4u40 29 14 a a DT cord-006608-mq4a4u40 29 15 striped striped JJ cord-006608-mq4a4u40 29 16 field field NN cord-006608-mq4a4u40 29 17 mouse mouse NN cord-006608-mq4a4u40 29 18 near near IN cord-006608-mq4a4u40 29 19 the the DT cord-006608-mq4a4u40 29 20 Hantaan Hantaan NNP cord-006608-mq4a4u40 29 21 River River NNP cord-006608-mq4a4u40 29 22 in in IN cord-006608-mq4a4u40 29 23 South South NNP cord-006608-mq4a4u40 29 24 Korea Korea NNP cord-006608-mq4a4u40 29 25 . . . cord-006608-mq4a4u40 30 1 Unlike unlike IN cord-006608-mq4a4u40 30 2 other other JJ cord-006608-mq4a4u40 30 3 members member NNS cord-006608-mq4a4u40 30 4 of of IN cord-006608-mq4a4u40 30 5 the the DT cord-006608-mq4a4u40 30 6 Bunyavirus Bunyavirus NNP cord-006608-mq4a4u40 30 7 family family NN cord-006608-mq4a4u40 30 8 that that WDT cord-006608-mq4a4u40 30 9 are be VBP cord-006608-mq4a4u40 30 10 transmitted transmit VBN cord-006608-mq4a4u40 30 11 to to IN cord-006608-mq4a4u40 30 12 humans human NNS cord-006608-mq4a4u40 30 13 by by IN cord-006608-mq4a4u40 30 14 arthropod arthropod JJ cord-006608-mq4a4u40 30 15 vectors vector NNS cord-006608-mq4a4u40 30 16 , , , cord-006608-mq4a4u40 30 17 hantaviruses hantaviruses NNPS cord-006608-mq4a4u40 30 18 are be VBP cord-006608-mq4a4u40 30 19 transmitted transmit VBN cord-006608-mq4a4u40 30 20 via via IN cord-006608-mq4a4u40 30 21 inhalation inhalation NN cord-006608-mq4a4u40 30 22 of of IN cord-006608-mq4a4u40 30 23 viruscontaminated viruscontaminate VBN cord-006608-mq4a4u40 30 24 aerosols aerosol NNS cord-006608-mq4a4u40 30 25 of of IN cord-006608-mq4a4u40 30 26 rodent rodent NN cord-006608-mq4a4u40 30 27 saliva saliva NN cord-006608-mq4a4u40 30 28 , , , cord-006608-mq4a4u40 30 29 urine urine NN cord-006608-mq4a4u40 30 30 , , , cord-006608-mq4a4u40 30 31 and and CC cord-006608-mq4a4u40 30 32 feces fece NNS cord-006608-mq4a4u40 30 33 . . . cord-006608-mq4a4u40 31 1 The the DT cord-006608-mq4a4u40 31 2 hantavirus hantavirus NN cord-006608-mq4a4u40 31 3 genome genome NN cord-006608-mq4a4u40 31 4 consists consist VBZ cord-006608-mq4a4u40 31 5 of of IN cord-006608-mq4a4u40 31 6 three three CD cord-006608-mq4a4u40 31 7 segments segment NNS cord-006608-mq4a4u40 31 8 . . . cord-006608-mq4a4u40 32 1 The the DT cord-006608-mq4a4u40 32 2 large large JJ cord-006608-mq4a4u40 32 3 ( ( -LRB- cord-006608-mq4a4u40 32 4 L l NN cord-006608-mq4a4u40 32 5 ) ) -RRB- cord-006608-mq4a4u40 32 6 segment segment NN cord-006608-mq4a4u40 32 7 encodes encode VBZ cord-006608-mq4a4u40 32 8 a a DT cord-006608-mq4a4u40 32 9 protein protein NN cord-006608-mq4a4u40 32 10 with with IN cord-006608-mq4a4u40 32 11 replicase replicase NN cord-006608-mq4a4u40 32 12 , , , cord-006608-mq4a4u40 32 13 transcriptase transcriptase NN cord-006608-mq4a4u40 32 14 , , , cord-006608-mq4a4u40 32 15 and and CC cord-006608-mq4a4u40 32 16 endonuclease endonuclease NN cord-006608-mq4a4u40 32 17 activity activity NN cord-006608-mq4a4u40 32 18 . . . cord-006608-mq4a4u40 33 1 The the DT cord-006608-mq4a4u40 33 2 medium medium NN cord-006608-mq4a4u40 33 3 ( ( -LRB- cord-006608-mq4a4u40 33 4 M M NNP cord-006608-mq4a4u40 33 5 ) ) -RRB- cord-006608-mq4a4u40 33 6 segment segment NN cord-006608-mq4a4u40 33 7 encodes encode VBZ cord-006608-mq4a4u40 33 8 a a DT cord-006608-mq4a4u40 33 9 precursor precursor NN cord-006608-mq4a4u40 33 10 protein protein NN cord-006608-mq4a4u40 33 11 that that WDT cord-006608-mq4a4u40 33 12 is be VBZ cord-006608-mq4a4u40 33 13 processed process VBN cord-006608-mq4a4u40 33 14 to to TO cord-006608-mq4a4u40 33 15 form form VB cord-006608-mq4a4u40 33 16 the the DT cord-006608-mq4a4u40 33 17 surface surface NN cord-006608-mq4a4u40 33 18 glycoproteins glycoprotein NNS cord-006608-mq4a4u40 33 19 G1 G1 NNP cord-006608-mq4a4u40 33 20 and and CC cord-006608-mq4a4u40 33 21 G2 G2 NNP cord-006608-mq4a4u40 33 22 , , , cord-006608-mq4a4u40 33 23 one one CD cord-006608-mq4a4u40 33 24 or or CC cord-006608-mq4a4u40 33 25 both both DT cord-006608-mq4a4u40 33 26 of of IN cord-006608-mq4a4u40 33 27 which which WDT cord-006608-mq4a4u40 33 28 play play VBP cord-006608-mq4a4u40 33 29 a a DT cord-006608-mq4a4u40 33 30 role role NN cord-006608-mq4a4u40 33 31 in in IN cord-006608-mq4a4u40 33 32 viral viral JJ cord-006608-mq4a4u40 33 33 neutralization neutralization NN cord-006608-mq4a4u40 33 34 , , , cord-006608-mq4a4u40 33 35 fusion fusion NN cord-006608-mq4a4u40 33 36 of of IN cord-006608-mq4a4u40 33 37 infected infected JJ cord-006608-mq4a4u40 33 38 cells cell NNS cord-006608-mq4a4u40 33 39 , , , cord-006608-mq4a4u40 33 40 and and CC cord-006608-mq4a4u40 33 41 hemagglutination hemagglutination NN cord-006608-mq4a4u40 33 42 . . . cord-006608-mq4a4u40 34 1 The the DT cord-006608-mq4a4u40 34 2 small small JJ cord-006608-mq4a4u40 34 3 ( ( -LRB- cord-006608-mq4a4u40 34 4 S s NN cord-006608-mq4a4u40 34 5 ) ) -RRB- cord-006608-mq4a4u40 34 6 segment segment NN cord-006608-mq4a4u40 34 7 encodes encode VBZ cord-006608-mq4a4u40 34 8 the the DT cord-006608-mq4a4u40 34 9 nucleocapsid nucleocapsid NNP cord-006608-mq4a4u40 34 10 protein protein NN cord-006608-mq4a4u40 34 11 , , , cord-006608-mq4a4u40 34 12 which which WDT cord-006608-mq4a4u40 34 13 forms form VBZ cord-006608-mq4a4u40 34 14 the the DT cord-006608-mq4a4u40 34 15 filamentous filamentous JJ cord-006608-mq4a4u40 34 16 helical helical JJ cord-006608-mq4a4u40 34 17 nucleocapsid nucleocapsid NN cord-006608-mq4a4u40 34 18 of of IN cord-006608-mq4a4u40 34 19 this this DT cord-006608-mq4a4u40 34 20 virus virus NN cord-006608-mq4a4u40 34 21 and and CC cord-006608-mq4a4u40 34 22 elicits elicit VBZ cord-006608-mq4a4u40 34 23 the the DT cord-006608-mq4a4u40 34 24 humoral humoral JJ cord-006608-mq4a4u40 34 25 immune immune JJ cord-006608-mq4a4u40 34 26 response response NN cord-006608-mq4a4u40 34 27 . . . cord-006608-mq4a4u40 35 1 Hantaviruses hantaviruse NNS cord-006608-mq4a4u40 35 2 have have VBP cord-006608-mq4a4u40 35 3 been be VBN cord-006608-mq4a4u40 35 4 characterized characterize VBN cord-006608-mq4a4u40 35 5 by by IN cord-006608-mq4a4u40 35 6 genetic genetic JJ cord-006608-mq4a4u40 35 7 and and CC cord-006608-mq4a4u40 35 8 antigenic antigenic JJ cord-006608-mq4a4u40 35 9 methods method NNS cord-006608-mq4a4u40 35 10 . . . cord-006608-mq4a4u40 36 1 Point point NN cord-006608-mq4a4u40 36 2 mutations mutation NNS cord-006608-mq4a4u40 36 3 appear appear VBP cord-006608-mq4a4u40 36 4 to to TO cord-006608-mq4a4u40 36 5 account account VB cord-006608-mq4a4u40 36 6 for for IN cord-006608-mq4a4u40 36 7 most most JJS cord-006608-mq4a4u40 36 8 of of IN cord-006608-mq4a4u40 36 9 the the DT cord-006608-mq4a4u40 36 10 genetic genetic JJ cord-006608-mq4a4u40 36 11 drift drift NN cord-006608-mq4a4u40 36 12 among among IN cord-006608-mq4a4u40 36 13 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 36 14 [ [ -LRB- cord-006608-mq4a4u40 36 15 7 7 CD cord-006608-mq4a4u40 36 16 ] ] -RRB- cord-006608-mq4a4u40 36 17 . . . cord-006608-mq4a4u40 37 1 RNA RNA NNP cord-006608-mq4a4u40 37 2 viruses virus NNS cord-006608-mq4a4u40 37 3 with with IN cord-006608-mq4a4u40 37 4 segmented segmented JJ cord-006608-mq4a4u40 37 5 genomes genome NNS cord-006608-mq4a4u40 37 6 , , , cord-006608-mq4a4u40 37 7 such such JJ cord-006608-mq4a4u40 37 8 as as IN cord-006608-mq4a4u40 37 9 influenza influenza NN cord-006608-mq4a4u40 37 10 virus virus NN cord-006608-mq4a4u40 37 11 , , . cord-006608-mq4a4u40 38 1 Since since IN cord-006608-mq4a4u40 38 2 the the DT cord-006608-mq4a4u40 38 3 first first JJ cord-006608-mq4a4u40 38 4 outbreak outbreak NN cord-006608-mq4a4u40 38 5 of of IN cord-006608-mq4a4u40 38 6 hantavirus hantavirus NN cord-006608-mq4a4u40 38 7 pulmonary pulmonary JJ cord-006608-mq4a4u40 38 8 syndrome syndrome NN cord-006608-mq4a4u40 38 9 ( ( -LRB- cord-006608-mq4a4u40 38 10 HPS HPS NNP cord-006608-mq4a4u40 38 11 ) ) -RRB- cord-006608-mq4a4u40 38 12 in in IN cord-006608-mq4a4u40 38 13 1993 1993 CD cord-006608-mq4a4u40 38 14 , , , cord-006608-mq4a4u40 38 15 understanding understanding NN cord-006608-mq4a4u40 38 16 of of IN cord-006608-mq4a4u40 38 17 the the DT cord-006608-mq4a4u40 38 18 vast vast JJ cord-006608-mq4a4u40 38 19 distribution distribution NN cord-006608-mq4a4u40 38 20 and and CC cord-006608-mq4a4u40 38 21 potential potential JJ cord-006608-mq4a4u40 38 22 impact impact NN cord-006608-mq4a4u40 38 23 of of IN cord-006608-mq4a4u40 38 24 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 38 25 has have VBZ cord-006608-mq4a4u40 38 26 grown grow VBN cord-006608-mq4a4u40 38 27 . . . cord-006608-mq4a4u40 39 1 At at RB cord-006608-mq4a4u40 39 2 least least RBS cord-006608-mq4a4u40 39 3 277 277 CD cord-006608-mq4a4u40 39 4 cases case NNS cord-006608-mq4a4u40 39 5 of of IN cord-006608-mq4a4u40 39 6 HPS HPS NNP cord-006608-mq4a4u40 39 7 have have VBP cord-006608-mq4a4u40 39 8 been be VBN cord-006608-mq4a4u40 39 9 documented document VBN cord-006608-mq4a4u40 39 10 in in IN cord-006608-mq4a4u40 39 11 the the DT cord-006608-mq4a4u40 39 12 United United NNP cord-006608-mq4a4u40 39 13 States States NNP cord-006608-mq4a4u40 39 14 . . . cord-006608-mq4a4u40 40 1 The the DT cord-006608-mq4a4u40 40 2 full full JJ cord-006608-mq4a4u40 40 3 clinical clinical JJ cord-006608-mq4a4u40 40 4 spectrum spectrum NN cord-006608-mq4a4u40 40 5 has have VBZ cord-006608-mq4a4u40 40 6 yet yet RB cord-006608-mq4a4u40 40 7 to to TO cord-006608-mq4a4u40 40 8 be be VB cord-006608-mq4a4u40 40 9 elucidated elucidate VBN cord-006608-mq4a4u40 40 10 , , , cord-006608-mq4a4u40 40 11 and and CC cord-006608-mq4a4u40 40 12 one one CD cord-006608-mq4a4u40 40 13 outbreak outbreak NN cord-006608-mq4a4u40 40 14 suggested suggest VBD cord-006608-mq4a4u40 40 15 the the DT cord-006608-mq4a4u40 40 16 possibility possibility NN cord-006608-mq4a4u40 40 17 of of IN cord-006608-mq4a4u40 40 18 person person NN cord-006608-mq4a4u40 40 19 - - HYPH cord-006608-mq4a4u40 40 20 to to IN cord-006608-mq4a4u40 40 21 - - HYPH cord-006608-mq4a4u40 40 22 person person NN cord-006608-mq4a4u40 40 23 transmission transmission NN cord-006608-mq4a4u40 40 24 . . . cord-006608-mq4a4u40 41 1 New new JJ cord-006608-mq4a4u40 41 2 research research NN cord-006608-mq4a4u40 41 3 has have VBZ cord-006608-mq4a4u40 41 4 identified identify VBN cord-006608-mq4a4u40 41 5 the the DT cord-006608-mq4a4u40 41 6 β-3 β-3 NNP cord-006608-mq4a4u40 41 7 integrins integrin NNS cord-006608-mq4a4u40 41 8 as as IN cord-006608-mq4a4u40 41 9 cellular cellular JJ cord-006608-mq4a4u40 41 10 receptors receptor NNS cord-006608-mq4a4u40 41 11 for for IN cord-006608-mq4a4u40 41 12 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 41 13 and and CC cord-006608-mq4a4u40 41 14 has have VBZ cord-006608-mq4a4u40 41 15 determined determine VBN cord-006608-mq4a4u40 41 16 the the DT cord-006608-mq4a4u40 41 17 pivotal pivotal JJ cord-006608-mq4a4u40 41 18 role role NN cord-006608-mq4a4u40 41 19 of of IN cord-006608-mq4a4u40 41 20 the the DT cord-006608-mq4a4u40 41 21 immune immune JJ cord-006608-mq4a4u40 41 22 system system NN cord-006608-mq4a4u40 41 23 in in IN cord-006608-mq4a4u40 41 24 pathogenesis pathogenesis NN cord-006608-mq4a4u40 41 25 . . . cord-006608-mq4a4u40 42 1 Rapid rapid JJ cord-006608-mq4a4u40 42 2 diagnosis diagnosis NN cord-006608-mq4a4u40 42 3 has have VBZ cord-006608-mq4a4u40 42 4 been be VBN cord-006608-mq4a4u40 42 5 facilitated facilitate VBN cord-006608-mq4a4u40 42 6 by by IN cord-006608-mq4a4u40 42 7 a a DT cord-006608-mq4a4u40 42 8 new new JJ cord-006608-mq4a4u40 42 9 immunoblot immunoblot NNP cord-006608-mq4a4u40 42 10 assay assay NN cord-006608-mq4a4u40 42 11 to to TO cord-006608-mq4a4u40 42 12 detect detect VB cord-006608-mq4a4u40 42 13 Sin sin NN cord-006608-mq4a4u40 42 14 Nombre Nombre NNP cord-006608-mq4a4u40 42 15 virus virus NN cord-006608-mq4a4u40 42 16 infection infection NN cord-006608-mq4a4u40 42 17 . . . cord-006608-mq4a4u40 43 1 Treatment treatment NN cord-006608-mq4a4u40 43 2 remains remain VBZ cord-006608-mq4a4u40 43 3 primarily primarily RB cord-006608-mq4a4u40 43 4 supportive supportive JJ cord-006608-mq4a4u40 43 5 ; ; : cord-006608-mq4a4u40 43 6 however however RB cord-006608-mq4a4u40 43 7 , , , cord-006608-mq4a4u40 43 8 a a DT cord-006608-mq4a4u40 43 9 placebocontrolled placebocontrolled JJ cord-006608-mq4a4u40 43 10 trial trial NN cord-006608-mq4a4u40 43 11 of of IN cord-006608-mq4a4u40 43 12 ribavirin ribavirin NNP cord-006608-mq4a4u40 43 13 is be VBZ cord-006608-mq4a4u40 43 14 ongoing ongoing JJ cord-006608-mq4a4u40 43 15 . . . cord-006608-mq4a4u40 44 1 Extracorporeal extracorporeal JJ cord-006608-mq4a4u40 44 2 membrane membrane NN cord-006608-mq4a4u40 44 3 oxygenation oxygenation NN cord-006608-mq4a4u40 44 4 may may MD cord-006608-mq4a4u40 44 5 be be VB cord-006608-mq4a4u40 44 6 a a DT cord-006608-mq4a4u40 44 7 potential potential JJ cord-006608-mq4a4u40 44 8 therapy therapy NN cord-006608-mq4a4u40 44 9 in in IN cord-006608-mq4a4u40 44 10 severe severe JJ cord-006608-mq4a4u40 44 11 cases case NNS cord-006608-mq4a4u40 44 12 ; ; , cord-006608-mq4a4u40 44 13 inhaled inhale VBN cord-006608-mq4a4u40 44 14 nitric nitric NN cord-006608-mq4a4u40 44 15 oxide oxide NN cord-006608-mq4a4u40 44 16 needs need VBZ cord-006608-mq4a4u40 44 17 further further JJ cord-006608-mq4a4u40 44 18 study study NN cord-006608-mq4a4u40 44 19 . . . cord-006608-mq4a4u40 45 1 Vaccines vaccine NNS cord-006608-mq4a4u40 45 2 developed develop VBD cord-006608-mq4a4u40 45 3 against against IN cord-006608-mq4a4u40 45 4 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 45 5 associated associate VBN cord-006608-mq4a4u40 45 6 with with IN cord-006608-mq4a4u40 45 7 hemorrhagic hemorrhagic JJ cord-006608-mq4a4u40 45 8 fever fever NN cord-006608-mq4a4u40 45 9 and and CC cord-006608-mq4a4u40 45 10 renal renal JJ cord-006608-mq4a4u40 45 11 syndrome syndrome NN cord-006608-mq4a4u40 45 12 might may MD cord-006608-mq4a4u40 45 13 be be VB cord-006608-mq4a4u40 45 14 effective effective JJ cord-006608-mq4a4u40 45 15 against against IN cord-006608-mq4a4u40 45 16 HPS hps NN cord-006608-mq4a4u40 45 17 - - HYPH cord-006608-mq4a4u40 45 18 associated associate VBN cord-006608-mq4a4u40 45 19 strains strain NNS cord-006608-mq4a4u40 45 20 . . . cord-006608-mq4a4u40 46 1 can can MD cord-006608-mq4a4u40 46 2 reassort reassort VB cord-006608-mq4a4u40 46 3 their -PRON- PRP$ cord-006608-mq4a4u40 46 4 RNA RNA NNP cord-006608-mq4a4u40 46 5 segments segment NNS cord-006608-mq4a4u40 46 6 when when WRB cord-006608-mq4a4u40 46 7 dual dual JJ cord-006608-mq4a4u40 46 8 infection infection NN cord-006608-mq4a4u40 46 9 of of IN cord-006608-mq4a4u40 46 10 a a DT cord-006608-mq4a4u40 46 11 target target NN cord-006608-mq4a4u40 46 12 cell cell NN cord-006608-mq4a4u40 46 13 occurs occur VBZ cord-006608-mq4a4u40 46 14 . . . cord-006608-mq4a4u40 47 1 Genetic genetic JJ cord-006608-mq4a4u40 47 2 reassortment reassortment NN cord-006608-mq4a4u40 47 3 has have VBZ cord-006608-mq4a4u40 47 4 been be VBN cord-006608-mq4a4u40 47 5 demonstrated demonstrate VBN cord-006608-mq4a4u40 47 6 in in IN cord-006608-mq4a4u40 47 7 nature nature NN cord-006608-mq4a4u40 47 8 and and CC cord-006608-mq4a4u40 47 9 in in IN cord-006608-mq4a4u40 47 10 vitro vitro FW cord-006608-mq4a4u40 47 11 for for IN cord-006608-mq4a4u40 47 12 Bunyaviridae Bunyaviridae NNP cord-006608-mq4a4u40 47 13 that that WDT cord-006608-mq4a4u40 47 14 cause cause VBP cord-006608-mq4a4u40 47 15 arthropod arthropod NN cord-006608-mq4a4u40 47 16 - - HYPH cord-006608-mq4a4u40 47 17 borne bear VBN cord-006608-mq4a4u40 47 18 disease disease NN cord-006608-mq4a4u40 47 19 , , , cord-006608-mq4a4u40 47 20 but but CC cord-006608-mq4a4u40 47 21 little little JJ cord-006608-mq4a4u40 47 22 information information NN cord-006608-mq4a4u40 47 23 is be VBZ cord-006608-mq4a4u40 47 24 available available JJ cord-006608-mq4a4u40 47 25 about about IN cord-006608-mq4a4u40 47 26 HPS hps NN cord-006608-mq4a4u40 47 27 - - HYPH cord-006608-mq4a4u40 47 28 associated associate VBN cord-006608-mq4a4u40 47 29 strains strain NNS cord-006608-mq4a4u40 47 30 . . . cord-006608-mq4a4u40 48 1 Two two CD cord-006608-mq4a4u40 48 2 previous previous JJ cord-006608-mq4a4u40 48 3 studies study NNS cord-006608-mq4a4u40 48 4 analyzing analyze VBG cord-006608-mq4a4u40 48 5 genomic genomic JJ cord-006608-mq4a4u40 48 6 SNV SNV NNP cord-006608-mq4a4u40 48 7 RNA RNA NNP cord-006608-mq4a4u40 48 8 sequences sequence NNS cord-006608-mq4a4u40 48 9 from from IN cord-006608-mq4a4u40 48 10 humans human NNS cord-006608-mq4a4u40 48 11 and and CC cord-006608-mq4a4u40 48 12 rodents rodent NNS cord-006608-mq4a4u40 48 13 suggest suggest VBP cord-006608-mq4a4u40 48 14 that that IN cord-006608-mq4a4u40 48 15 the the DT cord-006608-mq4a4u40 48 16 RNA RNA NNP cord-006608-mq4a4u40 48 17 segment segment NN cord-006608-mq4a4u40 48 18 has have VBZ cord-006608-mq4a4u40 48 19 been be VBN cord-006608-mq4a4u40 48 20 reassorted reassorte VBN cord-006608-mq4a4u40 48 21 in in IN cord-006608-mq4a4u40 48 22 nature nature NN cord-006608-mq4a4u40 48 23 between between IN cord-006608-mq4a4u40 48 24 SNV SNV NNP cord-006608-mq4a4u40 48 25 genetic genetic JJ cord-006608-mq4a4u40 48 26 variants variant NNS cord-006608-mq4a4u40 48 27 [ [ -LRB- cord-006608-mq4a4u40 48 28 8 8 CD cord-006608-mq4a4u40 48 29 , , , cord-006608-mq4a4u40 48 30 9 9 CD cord-006608-mq4a4u40 48 31 ] ] -RRB- cord-006608-mq4a4u40 48 32 . . . cord-006608-mq4a4u40 49 1 Rodriquez Rodriquez NNP cord-006608-mq4a4u40 49 2 et et NNP cord-006608-mq4a4u40 49 3 al al NNP cord-006608-mq4a4u40 49 4 . . . cord-006608-mq4a4u40 50 1 [ [ -LRB- cord-006608-mq4a4u40 50 2 10 10 CD cord-006608-mq4a4u40 50 3 ] ] -RRB- cord-006608-mq4a4u40 50 4 analyzed analyze VBN cord-006608-mq4a4u40 50 5 progeny progeny JJ cord-006608-mq4a4u40 50 6 virus virus NN cord-006608-mq4a4u40 50 7 from from IN cord-006608-mq4a4u40 50 8 co co NNS cord-006608-mq4a4u40 50 9 - - NNS cord-006608-mq4a4u40 50 10 cultures culture NNS cord-006608-mq4a4u40 50 11 of of IN cord-006608-mq4a4u40 50 12 closely closely RB cord-006608-mq4a4u40 50 13 related relate VBN cord-006608-mq4a4u40 50 14 SNV SNV NNP cord-006608-mq4a4u40 50 15 strains strain NNS cord-006608-mq4a4u40 50 16 with with IN cord-006608-mq4a4u40 50 17 identical identical JJ cord-006608-mq4a4u40 50 18 rodent rodent NN cord-006608-mq4a4u40 50 19 hosts host NNS cord-006608-mq4a4u40 50 20 and and CC cord-006608-mq4a4u40 50 21 of of IN cord-006608-mq4a4u40 50 22 SNV SNV NNP cord-006608-mq4a4u40 50 23 and and CC cord-006608-mq4a4u40 50 24 Black Black NNP cord-006608-mq4a4u40 50 25 Creek Creek NNP cord-006608-mq4a4u40 50 26 Canal Canal NNP cord-006608-mq4a4u40 50 27 virus virus NN cord-006608-mq4a4u40 50 28 , , , cord-006608-mq4a4u40 50 29 which which WDT cord-006608-mq4a4u40 50 30 have have VBP cord-006608-mq4a4u40 50 31 different different JJ cord-006608-mq4a4u40 50 32 rodent rodent NN cord-006608-mq4a4u40 50 33 hosts host NNS cord-006608-mq4a4u40 50 34 . . . cord-006608-mq4a4u40 51 1 Reassortants reassortant NNS cord-006608-mq4a4u40 51 2 were be VBD cord-006608-mq4a4u40 51 3 observed observe VBN cord-006608-mq4a4u40 51 4 frequently frequently RB cord-006608-mq4a4u40 51 5 between between IN cord-006608-mq4a4u40 51 6 closely closely RB cord-006608-mq4a4u40 51 7 related related JJ cord-006608-mq4a4u40 51 8 strains strain NNS cord-006608-mq4a4u40 51 9 but but CC cord-006608-mq4a4u40 51 10 were be VBD cord-006608-mq4a4u40 51 11 rare rare JJ cord-006608-mq4a4u40 51 12 between between IN cord-006608-mq4a4u40 51 13 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 51 14 with with IN cord-006608-mq4a4u40 51 15 different different JJ cord-006608-mq4a4u40 51 16 rodent rodent NN cord-006608-mq4a4u40 51 17 hosts host NNS cord-006608-mq4a4u40 51 18 . . . cord-006608-mq4a4u40 52 1 These these DT cord-006608-mq4a4u40 52 2 data datum NNS cord-006608-mq4a4u40 52 3 suggest suggest VBP cord-006608-mq4a4u40 52 4 that that IN cord-006608-mq4a4u40 52 5 genetic genetic JJ cord-006608-mq4a4u40 52 6 reassortment reassortment NN cord-006608-mq4a4u40 52 7 in in IN cord-006608-mq4a4u40 52 8 nature nature NN cord-006608-mq4a4u40 52 9 may may MD cord-006608-mq4a4u40 52 10 contribute contribute VB cord-006608-mq4a4u40 52 11 to to IN cord-006608-mq4a4u40 52 12 the the DT cord-006608-mq4a4u40 52 13 emergence emergence NN cord-006608-mq4a4u40 52 14 of of IN cord-006608-mq4a4u40 52 15 new new JJ cord-006608-mq4a4u40 52 16 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 52 17 . . . cord-006608-mq4a4u40 53 1 Hantaviruses Hantaviruses NNP cord-006608-mq4a4u40 53 2 are be VBP cord-006608-mq4a4u40 53 3 subdivided subdivide VBN cord-006608-mq4a4u40 53 4 into into IN cord-006608-mq4a4u40 53 5 genogroups genogroup NNS cord-006608-mq4a4u40 53 6 on on IN cord-006608-mq4a4u40 53 7 the the DT cord-006608-mq4a4u40 53 8 basis basis NN cord-006608-mq4a4u40 53 9 of of IN cord-006608-mq4a4u40 53 10 nucleotide nucleotide JJ cord-006608-mq4a4u40 53 11 sequence sequence NN cord-006608-mq4a4u40 53 12 analysis analysis NN cord-006608-mq4a4u40 53 13 of of IN cord-006608-mq4a4u40 53 14 S S NNP cord-006608-mq4a4u40 53 15 and and CC cord-006608-mq4a4u40 53 16 M M NNP cord-006608-mq4a4u40 53 17 segments segment NNS cord-006608-mq4a4u40 53 18 . . . cord-006608-mq4a4u40 54 1 Each each DT cord-006608-mq4a4u40 54 2 genogroup genogroup NN cord-006608-mq4a4u40 54 3 usually usually RB cord-006608-mq4a4u40 54 4 infects infect VBZ cord-006608-mq4a4u40 54 5 a a DT cord-006608-mq4a4u40 54 6 single single JJ cord-006608-mq4a4u40 54 7 rodent rodent NN cord-006608-mq4a4u40 54 8 species specie NNS cord-006608-mq4a4u40 54 9 . . . cord-006608-mq4a4u40 55 1 The the DT cord-006608-mq4a4u40 55 2 New New NNP cord-006608-mq4a4u40 55 3 World World NNP cord-006608-mq4a4u40 55 4 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 55 5 are be VBP cord-006608-mq4a4u40 55 6 more more RBR cord-006608-mq4a4u40 55 7 closely closely RB cord-006608-mq4a4u40 55 8 interrelated interrelated JJ cord-006608-mq4a4u40 55 9 than than IN cord-006608-mq4a4u40 55 10 the the DT cord-006608-mq4a4u40 55 11 Old Old NNP cord-006608-mq4a4u40 55 12 World World NNP cord-006608-mq4a4u40 55 13 viruses virus NNS cord-006608-mq4a4u40 55 14 , , , cord-006608-mq4a4u40 55 15 and and CC cord-006608-mq4a4u40 55 16 vice vice NN cord-006608-mq4a4u40 55 17 versa versa RB cord-006608-mq4a4u40 55 18 . . . cord-006608-mq4a4u40 56 1 The the DT cord-006608-mq4a4u40 56 2 HPS HPS NNP cord-006608-mq4a4u40 56 3 - - HYPH cord-006608-mq4a4u40 56 4 associated associate VBN cord-006608-mq4a4u40 56 5 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 56 6 belong belong VBP cord-006608-mq4a4u40 56 7 to to IN cord-006608-mq4a4u40 56 8 the the DT cord-006608-mq4a4u40 56 9 New New NNP cord-006608-mq4a4u40 56 10 World World NNP cord-006608-mq4a4u40 56 11 group group NN cord-006608-mq4a4u40 56 12 ; ; : cord-006608-mq4a4u40 56 13 these these DT cord-006608-mq4a4u40 56 14 include include VBP cord-006608-mq4a4u40 56 15 Sin Sin NNP cord-006608-mq4a4u40 56 16 Nombre Nombre NNP cord-006608-mq4a4u40 56 17 , , , cord-006608-mq4a4u40 56 18 Bayou Bayou NNP cord-006608-mq4a4u40 56 19 , , , cord-006608-mq4a4u40 56 20 Black Black NNP cord-006608-mq4a4u40 56 21 Creek Creek NNP cord-006608-mq4a4u40 56 22 Canal Canal NNP cord-006608-mq4a4u40 56 23 , , , cord-006608-mq4a4u40 56 24 New New NNP cord-006608-mq4a4u40 56 25 York York NNP cord-006608-mq4a4u40 56 26 , , , cord-006608-mq4a4u40 56 27 and and CC cord-006608-mq4a4u40 56 28 Andes Andes NNP cord-006608-mq4a4u40 56 29 viruses virus NNS cord-006608-mq4a4u40 56 30 ( ( -LRB- cord-006608-mq4a4u40 56 31 Table table NN cord-006608-mq4a4u40 56 32 2 2 CD cord-006608-mq4a4u40 56 33 ) ) -RRB- cord-006608-mq4a4u40 56 34 . . . cord-006608-mq4a4u40 57 1 The the DT cord-006608-mq4a4u40 57 2 Old Old NNP cord-006608-mq4a4u40 57 3 World World NNP cord-006608-mq4a4u40 57 4 group group NN cord-006608-mq4a4u40 57 5 includes include VBZ cord-006608-mq4a4u40 57 6 Hantaan Hantaan NNP cord-006608-mq4a4u40 57 7 , , , cord-006608-mq4a4u40 57 8 Dobrava Dobrava NNP cord-006608-mq4a4u40 57 9 , , , cord-006608-mq4a4u40 57 10 Seoul Seoul NNP cord-006608-mq4a4u40 57 11 , , , cord-006608-mq4a4u40 57 12 and and CC cord-006608-mq4a4u40 57 13 Puumala Puumala NNP cord-006608-mq4a4u40 57 14 viruses virus NNS cord-006608-mq4a4u40 57 15 , , , cord-006608-mq4a4u40 57 16 which which WDT cord-006608-mq4a4u40 57 17 cause cause VBP cord-006608-mq4a4u40 57 18 hemorrhagic hemorrhagic JJ cord-006608-mq4a4u40 57 19 fever fever NN cord-006608-mq4a4u40 57 20 with with IN cord-006608-mq4a4u40 57 21 renal renal JJ cord-006608-mq4a4u40 57 22 syndrome syndrome NN cord-006608-mq4a4u40 57 23 ( ( -LRB- cord-006608-mq4a4u40 57 24 HFRS HFRS NNP cord-006608-mq4a4u40 57 25 ) ) -RRB- cord-006608-mq4a4u40 57 26 . . . cord-006608-mq4a4u40 58 1 Each each DT cord-006608-mq4a4u40 58 2 hantavirus hantavirus NN cord-006608-mq4a4u40 58 3 is be VBZ cord-006608-mq4a4u40 58 4 maintained maintain VBN cord-006608-mq4a4u40 58 5 in in IN cord-006608-mq4a4u40 58 6 nature nature NN cord-006608-mq4a4u40 58 7 by by IN cord-006608-mq4a4u40 58 8 asymptomatic asymptomatic JJ cord-006608-mq4a4u40 58 9 infection infection NN cord-006608-mq4a4u40 58 10 of of IN cord-006608-mq4a4u40 58 11 a a DT cord-006608-mq4a4u40 58 12 single single JJ cord-006608-mq4a4u40 58 13 rodent rodent NN cord-006608-mq4a4u40 58 14 species specie NNS cord-006608-mq4a4u40 58 15 . . . cord-006608-mq4a4u40 59 1 Hantaviral Hantaviral NNP cord-006608-mq4a4u40 59 2 infection infection NN cord-006608-mq4a4u40 59 3 has have VBZ cord-006608-mq4a4u40 59 4 been be VBN cord-006608-mq4a4u40 59 5 documented document VBN cord-006608-mq4a4u40 59 6 in in IN cord-006608-mq4a4u40 59 7 cats cat NNS cord-006608-mq4a4u40 59 8 , , , cord-006608-mq4a4u40 59 9 birds bird NNS cord-006608-mq4a4u40 59 10 , , , cord-006608-mq4a4u40 59 11 and and CC cord-006608-mq4a4u40 59 12 bats bat NNS cord-006608-mq4a4u40 59 13 , , , cord-006608-mq4a4u40 59 14 but but CC cord-006608-mq4a4u40 59 15 these these DT cord-006608-mq4a4u40 59 16 hosts host NNS cord-006608-mq4a4u40 59 17 play play VBP cord-006608-mq4a4u40 59 18 no no DT cord-006608-mq4a4u40 59 19 documented document VBN cord-006608-mq4a4u40 59 20 role role NN cord-006608-mq4a4u40 59 21 in in IN cord-006608-mq4a4u40 59 22 human human JJ cord-006608-mq4a4u40 59 23 transmission transmission NN cord-006608-mq4a4u40 59 24 [ [ -LRB- cord-006608-mq4a4u40 59 25 11• 11• CD cord-006608-mq4a4u40 59 26 ] ] -RRB- cord-006608-mq4a4u40 59 27 . . . cord-006608-mq4a4u40 60 1 Rodents rodent NNS cord-006608-mq4a4u40 60 2 shed shed VBP cord-006608-mq4a4u40 60 3 infectious infectious JJ cord-006608-mq4a4u40 60 4 virus virus NN cord-006608-mq4a4u40 60 5 in in IN cord-006608-mq4a4u40 60 6 saliva saliva NN cord-006608-mq4a4u40 60 7 , , , cord-006608-mq4a4u40 60 8 urine urine NN cord-006608-mq4a4u40 60 9 , , , cord-006608-mq4a4u40 60 10 and and CC cord-006608-mq4a4u40 60 11 feces fece NNS cord-006608-mq4a4u40 60 12 for for IN cord-006608-mq4a4u40 60 13 prolonged prolonged JJ cord-006608-mq4a4u40 60 14 periods period NNS cord-006608-mq4a4u40 60 15 despite despite IN cord-006608-mq4a4u40 60 16 the the DT cord-006608-mq4a4u40 60 17 presence presence NN cord-006608-mq4a4u40 60 18 of of IN cord-006608-mq4a4u40 60 19 neutralizing neutralize VBG cord-006608-mq4a4u40 60 20 antibody antibody NN cord-006608-mq4a4u40 60 21 [ [ -LRB- cord-006608-mq4a4u40 60 22 12•• 12•• CD cord-006608-mq4a4u40 60 23 ] ] -RRB- cord-006608-mq4a4u40 60 24 . . . cord-006608-mq4a4u40 61 1 Rodents rodent NNS cord-006608-mq4a4u40 61 2 are be VBP cord-006608-mq4a4u40 61 3 infected infect VBN cord-006608-mq4a4u40 61 4 horizontally horizontally RB cord-006608-mq4a4u40 61 5 through through IN cord-006608-mq4a4u40 61 6 biting bite VBG cord-006608-mq4a4u40 61 7 and and CC cord-006608-mq4a4u40 61 8 scratching scratch VBG cord-006608-mq4a4u40 61 9 other other JJ cord-006608-mq4a4u40 61 10 rodents rodent NNS cord-006608-mq4a4u40 61 11 , , , cord-006608-mq4a4u40 61 12 as as IN cord-006608-mq4a4u40 61 13 reflected reflect VBN cord-006608-mq4a4u40 61 14 in in IN cord-006608-mq4a4u40 61 15 a a DT cord-006608-mq4a4u40 61 16 higher high JJR cord-006608-mq4a4u40 61 17 prevalence prevalence NN cord-006608-mq4a4u40 61 18 of of IN cord-006608-mq4a4u40 61 19 infection infection NN cord-006608-mq4a4u40 61 20 in in IN cord-006608-mq4a4u40 61 21 older old JJR cord-006608-mq4a4u40 61 22 male male JJ cord-006608-mq4a4u40 61 23 mice mouse NNS cord-006608-mq4a4u40 61 24 [ [ -LRB- cord-006608-mq4a4u40 61 25 13 13 CD cord-006608-mq4a4u40 61 26 ] ] -RRB- cord-006608-mq4a4u40 61 27 . . . cord-006608-mq4a4u40 62 1 Phylogenetic phylogenetic JJ cord-006608-mq4a4u40 62 2 relationships relationship NNS cord-006608-mq4a4u40 62 3 between between IN cord-006608-mq4a4u40 62 4 virus virus NN cord-006608-mq4a4u40 62 5 and and CC cord-006608-mq4a4u40 62 6 rodent rodent NN cord-006608-mq4a4u40 62 7 host host NN cord-006608-mq4a4u40 62 8 demonstrate demonstrate VBP cord-006608-mq4a4u40 62 9 a a DT cord-006608-mq4a4u40 62 10 co co NN cord-006608-mq4a4u40 62 11 - - NN cord-006608-mq4a4u40 62 12 evolution evolution NN cord-006608-mq4a4u40 62 13 over over IN cord-006608-mq4a4u40 62 14 thousands thousand NNS cord-006608-mq4a4u40 62 15 of of IN cord-006608-mq4a4u40 62 16 years year NNS cord-006608-mq4a4u40 62 17 . . . cord-006608-mq4a4u40 63 1 Studies study NNS cord-006608-mq4a4u40 63 2 in in IN cord-006608-mq4a4u40 63 3 which which WDT cord-006608-mq4a4u40 63 4 hantaviral hantaviral JJ cord-006608-mq4a4u40 63 5 gene gene NN cord-006608-mq4a4u40 63 6 sequences sequence NNS cord-006608-mq4a4u40 63 7 are be VBP cord-006608-mq4a4u40 63 8 compared compare VBN cord-006608-mq4a4u40 63 9 to to IN cord-006608-mq4a4u40 63 10 rodent rodent NN cord-006608-mq4a4u40 63 11 mitochondrial mitochondrial NN cord-006608-mq4a4u40 63 12 gene gene NN cord-006608-mq4a4u40 63 13 sequences sequence NNS cord-006608-mq4a4u40 63 14 allow allow VBP cord-006608-mq4a4u40 63 15 nearly nearly RB cord-006608-mq4a4u40 63 16 identical identical JJ cord-006608-mq4a4u40 63 17 phylogenetic phylogenetic JJ cord-006608-mq4a4u40 63 18 trees tree NNS cord-006608-mq4a4u40 63 19 to to TO cord-006608-mq4a4u40 63 20 be be VB cord-006608-mq4a4u40 63 21 constructed construct VBN cord-006608-mq4a4u40 63 22 [ [ -LRB- cord-006608-mq4a4u40 63 23 14 14 CD cord-006608-mq4a4u40 63 24 ] ] -RRB- cord-006608-mq4a4u40 63 25 . . . cord-006608-mq4a4u40 64 1 Several several JJ cord-006608-mq4a4u40 64 2 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 64 3 can can MD cord-006608-mq4a4u40 64 4 be be VB cord-006608-mq4a4u40 64 5 found find VBN cord-006608-mq4a4u40 64 6 in in IN cord-006608-mq4a4u40 64 7 one one CD cord-006608-mq4a4u40 64 8 geographic geographic JJ cord-006608-mq4a4u40 64 9 area area NN cord-006608-mq4a4u40 64 10 , , , cord-006608-mq4a4u40 64 11 each each DT cord-006608-mq4a4u40 64 12 circulating circulate VBG cord-006608-mq4a4u40 64 13 within within IN cord-006608-mq4a4u40 64 14 its -PRON- PRP$ cord-006608-mq4a4u40 64 15 specific specific JJ cord-006608-mq4a4u40 64 16 rodent rodent NN cord-006608-mq4a4u40 64 17 host host NN cord-006608-mq4a4u40 64 18 . . . cord-006608-mq4a4u40 65 1 Human human JJ cord-006608-mq4a4u40 65 2 transmission transmission NN cord-006608-mq4a4u40 65 3 usually usually RB cord-006608-mq4a4u40 65 4 occurs occur VBZ cord-006608-mq4a4u40 65 5 after after IN cord-006608-mq4a4u40 65 6 inhalation inhalation NN cord-006608-mq4a4u40 65 7 of of IN cord-006608-mq4a4u40 65 8 aerosols aerosol NNS cord-006608-mq4a4u40 65 9 of of IN cord-006608-mq4a4u40 65 10 infected infected JJ cord-006608-mq4a4u40 65 11 rodent rodent NN cord-006608-mq4a4u40 65 12 excreta excreta NN cord-006608-mq4a4u40 65 13 . . . cord-006608-mq4a4u40 66 1 The the DT cord-006608-mq4a4u40 66 2 virus virus NN cord-006608-mq4a4u40 66 3 may may MD cord-006608-mq4a4u40 66 4 also also RB cord-006608-mq4a4u40 66 5 be be VB cord-006608-mq4a4u40 66 6 transmitted transmit VBN cord-006608-mq4a4u40 66 7 after after IN cord-006608-mq4a4u40 66 8 rodent rodent NN cord-006608-mq4a4u40 66 9 bites bite NNS cord-006608-mq4a4u40 66 10 , , , cord-006608-mq4a4u40 66 11 after after IN cord-006608-mq4a4u40 66 12 inoculation inoculation NN cord-006608-mq4a4u40 66 13 of of IN cord-006608-mq4a4u40 66 14 infected infected JJ cord-006608-mq4a4u40 66 15 rodent rodent NN cord-006608-mq4a4u40 66 16 excreta excreta NN cord-006608-mq4a4u40 66 17 through through IN cord-006608-mq4a4u40 66 18 skin skin NN cord-006608-mq4a4u40 66 19 lesions lesion NNS cord-006608-mq4a4u40 66 20 or or CC cord-006608-mq4a4u40 66 21 eyes eye NNS cord-006608-mq4a4u40 66 22 , , , cord-006608-mq4a4u40 66 23 and and CC cord-006608-mq4a4u40 66 24 possibly possibly RB cord-006608-mq4a4u40 66 25 through through IN cord-006608-mq4a4u40 66 26 ingestion ingestion NN cord-006608-mq4a4u40 66 27 of of IN cord-006608-mq4a4u40 66 28 contaminated contaminate VBN cord-006608-mq4a4u40 66 29 food food NN cord-006608-mq4a4u40 66 30 or or CC cord-006608-mq4a4u40 66 31 water water NN cord-006608-mq4a4u40 66 32 [ [ -LRB- cord-006608-mq4a4u40 66 33 15 15 CD cord-006608-mq4a4u40 66 34 ] ] -RRB- cord-006608-mq4a4u40 66 35 . . . cord-006608-mq4a4u40 67 1 The the DT cord-006608-mq4a4u40 67 2 incubation incubation NN cord-006608-mq4a4u40 67 3 period period NN cord-006608-mq4a4u40 67 4 ranges range VBZ cord-006608-mq4a4u40 67 5 from from IN cord-006608-mq4a4u40 67 6 4 4 CD cord-006608-mq4a4u40 67 7 to to TO cord-006608-mq4a4u40 67 8 42 42 CD cord-006608-mq4a4u40 67 9 days day NNS cord-006608-mq4a4u40 67 10 ( ( -LRB- cord-006608-mq4a4u40 67 11 mean mean JJ cord-006608-mq4a4u40 67 12 range range NN cord-006608-mq4a4u40 67 13 , , , cord-006608-mq4a4u40 67 14 12 12 CD cord-006608-mq4a4u40 67 15 to to TO cord-006608-mq4a4u40 67 16 16 16 CD cord-006608-mq4a4u40 67 17 days day NNS cord-006608-mq4a4u40 67 18 ) ) -RRB- cord-006608-mq4a4u40 67 19 . . . cord-006608-mq4a4u40 68 1 The the DT cord-006608-mq4a4u40 68 2 risk risk NN cord-006608-mq4a4u40 68 3 for for IN cord-006608-mq4a4u40 68 4 human human JJ cord-006608-mq4a4u40 68 5 disease disease NN cord-006608-mq4a4u40 68 6 is be VBZ cord-006608-mq4a4u40 68 7 proportional proportional JJ cord-006608-mq4a4u40 68 8 to to IN cord-006608-mq4a4u40 68 9 the the DT cord-006608-mq4a4u40 68 10 frequency frequency NN cord-006608-mq4a4u40 68 11 of of IN cord-006608-mq4a4u40 68 12 exposure exposure NN cord-006608-mq4a4u40 68 13 to to IN cord-006608-mq4a4u40 68 14 infected infected JJ cord-006608-mq4a4u40 68 15 rodents rodent NNS cord-006608-mq4a4u40 68 16 . . . cord-006608-mq4a4u40 69 1 Rodent rodent NN cord-006608-mq4a4u40 69 2 populations population NNS cord-006608-mq4a4u40 69 3 may may MD cord-006608-mq4a4u40 69 4 vary vary VB cord-006608-mq4a4u40 69 5 seasonally seasonally RB cord-006608-mq4a4u40 69 6 and and CC cord-006608-mq4a4u40 69 7 can can MD cord-006608-mq4a4u40 69 8 increase increase VB cord-006608-mq4a4u40 69 9 tenfold tenfold RB cord-006608-mq4a4u40 69 10 in in IN cord-006608-mq4a4u40 69 11 2 2 CD cord-006608-mq4a4u40 69 12 months month NNS cord-006608-mq4a4u40 69 13 . . . cord-006608-mq4a4u40 70 1 Navajo Navajo NNP cord-006608-mq4a4u40 70 2 oral oral JJ cord-006608-mq4a4u40 70 3 tradition tradition NN cord-006608-mq4a4u40 70 4 recognized recognize VBD cord-006608-mq4a4u40 70 5 outbreaks outbreak NNS cord-006608-mq4a4u40 70 6 of of IN cord-006608-mq4a4u40 70 7 a a DT cord-006608-mq4a4u40 70 8 disease disease NN cord-006608-mq4a4u40 70 9 similar similar JJ cord-006608-mq4a4u40 70 10 to to IN cord-006608-mq4a4u40 70 11 HPS hps NN cord-006608-mq4a4u40 70 12 when when WRB cord-006608-mq4a4u40 70 13 large large JJ cord-006608-mq4a4u40 70 14 rodent rodent NN cord-006608-mq4a4u40 70 15 populations population NNS cord-006608-mq4a4u40 70 16 were be VBD cord-006608-mq4a4u40 70 17 present present JJ cord-006608-mq4a4u40 70 18 [ [ -LRB- cord-006608-mq4a4u40 70 19 16 16 CD cord-006608-mq4a4u40 70 20 ] ] -RRB- cord-006608-mq4a4u40 70 21 . . . cord-006608-mq4a4u40 71 1 In in IN cord-006608-mq4a4u40 71 2 the the DT cord-006608-mq4a4u40 71 3 fall fall NN cord-006608-mq4a4u40 71 4 of of IN cord-006608-mq4a4u40 71 5 1992 1992 CD cord-006608-mq4a4u40 71 6 , , , cord-006608-mq4a4u40 71 7 heavy heavy JJ cord-006608-mq4a4u40 71 8 precipitation precipitation NN cord-006608-mq4a4u40 71 9 in in IN cord-006608-mq4a4u40 71 10 a a DT cord-006608-mq4a4u40 71 11 previously previously RB cord-006608-mq4a4u40 71 12 drought drought NN cord-006608-mq4a4u40 71 13 - - HYPH cord-006608-mq4a4u40 71 14 stricken stricken VBN cord-006608-mq4a4u40 71 15 area area NN cord-006608-mq4a4u40 71 16 expanded expand VBD cord-006608-mq4a4u40 71 17 the the DT cord-006608-mq4a4u40 71 18 deer deer NN cord-006608-mq4a4u40 71 19 mouse mouse NN cord-006608-mq4a4u40 71 20 population population NN cord-006608-mq4a4u40 71 21 tenfold tenfold RB cord-006608-mq4a4u40 71 22 by by IN cord-006608-mq4a4u40 71 23 the the DT cord-006608-mq4a4u40 71 24 time time NN cord-006608-mq4a4u40 71 25 of of IN cord-006608-mq4a4u40 71 26 the the DT cord-006608-mq4a4u40 71 27 May May NNP cord-006608-mq4a4u40 71 28 1993 1993 CD cord-006608-mq4a4u40 71 29 outbreak outbreak NN cord-006608-mq4a4u40 71 30 [ [ -LRB- cord-006608-mq4a4u40 71 31 17 17 CD cord-006608-mq4a4u40 71 32 ] ] -RRB- cord-006608-mq4a4u40 71 33 . . . cord-006608-mq4a4u40 72 1 Vertical vertical JJ cord-006608-mq4a4u40 72 2 transmission transmission NN cord-006608-mq4a4u40 72 3 of of IN cord-006608-mq4a4u40 72 4 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 72 5 in in IN cord-006608-mq4a4u40 72 6 pregnant pregnant JJ cord-006608-mq4a4u40 72 7 women woman NNS cord-006608-mq4a4u40 72 8 with with IN cord-006608-mq4a4u40 72 9 HPS HPS NNP cord-006608-mq4a4u40 72 10 has have VBZ cord-006608-mq4a4u40 72 11 not not RB cord-006608-mq4a4u40 72 12 been be VBN cord-006608-mq4a4u40 72 13 demonstrated demonstrate VBN cord-006608-mq4a4u40 72 14 . . . cord-006608-mq4a4u40 73 1 In in IN cord-006608-mq4a4u40 73 2 a a DT cord-006608-mq4a4u40 73 3 recent recent JJ cord-006608-mq4a4u40 73 4 review review NN cord-006608-mq4a4u40 73 5 of of IN cord-006608-mq4a4u40 73 6 five five CD cord-006608-mq4a4u40 73 7 cases case NNS cord-006608-mq4a4u40 73 8 of of IN cord-006608-mq4a4u40 73 9 HPS hps NN cord-006608-mq4a4u40 73 10 in in IN cord-006608-mq4a4u40 73 11 pregnancy pregnancy NN cord-006608-mq4a4u40 73 12 [ [ -LRB- cord-006608-mq4a4u40 73 13 18• 18• JJ cord-006608-mq4a4u40 73 14 ] ] -RRB- cord-006608-mq4a4u40 73 15 , , , cord-006608-mq4a4u40 73 16 there there EX cord-006608-mq4a4u40 73 17 was be VBD cord-006608-mq4a4u40 73 18 no no DT cord-006608-mq4a4u40 73 19 pathologic pathologic JJ cord-006608-mq4a4u40 73 20 or or CC cord-006608-mq4a4u40 73 21 immunohistochemical immunohistochemical JJ cord-006608-mq4a4u40 73 22 evidence evidence NN cord-006608-mq4a4u40 73 23 of of IN cord-006608-mq4a4u40 73 24 HPS hps NN cord-006608-mq4a4u40 73 25 in in IN cord-006608-mq4a4u40 73 26 placental placental NN cord-006608-mq4a4u40 73 27 and and CC cord-006608-mq4a4u40 73 28 fetal fetal JJ cord-006608-mq4a4u40 73 29 tissue tissue NN cord-006608-mq4a4u40 73 30 from from IN cord-006608-mq4a4u40 73 31 two two CD cord-006608-mq4a4u40 73 32 in in IN cord-006608-mq4a4u40 73 33 utero utero NN cord-006608-mq4a4u40 73 34 deaths death NNS cord-006608-mq4a4u40 73 35 , , , cord-006608-mq4a4u40 73 36 or or CC cord-006608-mq4a4u40 73 37 serologic serologic JJ cord-006608-mq4a4u40 73 38 evidence evidence NN cord-006608-mq4a4u40 73 39 of of IN cord-006608-mq4a4u40 73 40 hantaviral hantaviral JJ cord-006608-mq4a4u40 73 41 infection infection NN cord-006608-mq4a4u40 73 42 in in IN cord-006608-mq4a4u40 73 43 the the DT cord-006608-mq4a4u40 73 44 two two CD cord-006608-mq4a4u40 73 45 live live JJ cord-006608-mq4a4u40 73 46 births birth NNS cord-006608-mq4a4u40 73 47 . . . cord-006608-mq4a4u40 74 1 This this DT cord-006608-mq4a4u40 74 2 review review NN cord-006608-mq4a4u40 74 3 identified identify VBD cord-006608-mq4a4u40 74 4 one one CD cord-006608-mq4a4u40 74 5 potential potential JJ cord-006608-mq4a4u40 74 6 case case NN cord-006608-mq4a4u40 74 7 of of IN cord-006608-mq4a4u40 74 8 perinatal perinatal JJ cord-006608-mq4a4u40 74 9 transmission transmission NN cord-006608-mq4a4u40 74 10 of of IN cord-006608-mq4a4u40 74 11 HFRS HFRS NNP cord-006608-mq4a4u40 74 12 from from IN cord-006608-mq4a4u40 74 13 Korea Korea NNP cord-006608-mq4a4u40 74 14 . . . cord-006608-mq4a4u40 75 1 No no DT cord-006608-mq4a4u40 75 2 evidence evidence NN cord-006608-mq4a4u40 75 3 suggests suggest VBZ cord-006608-mq4a4u40 75 4 transmission transmission NN cord-006608-mq4a4u40 75 5 via via IN cord-006608-mq4a4u40 75 6 breast breast NN cord-006608-mq4a4u40 75 7 feeding feeding NN cord-006608-mq4a4u40 75 8 in in IN cord-006608-mq4a4u40 75 9 humans human NNS cord-006608-mq4a4u40 75 10 or or CC cord-006608-mq4a4u40 75 11 animal animal NN cord-006608-mq4a4u40 75 12 models model NNS cord-006608-mq4a4u40 75 13 . . . cord-006608-mq4a4u40 76 1 The the DT cord-006608-mq4a4u40 76 2 issue issue NN cord-006608-mq4a4u40 76 3 of of IN cord-006608-mq4a4u40 76 4 person person NN cord-006608-mq4a4u40 76 5 - - HYPH cord-006608-mq4a4u40 76 6 to to IN cord-006608-mq4a4u40 76 7 - - HYPH cord-006608-mq4a4u40 76 8 person person NN cord-006608-mq4a4u40 76 9 transmission transmission NN cord-006608-mq4a4u40 76 10 is be VBZ cord-006608-mq4a4u40 76 11 controversial controversial JJ cord-006608-mq4a4u40 76 12 . . . cord-006608-mq4a4u40 77 1 In in IN cord-006608-mq4a4u40 77 2 a a DT cord-006608-mq4a4u40 77 3 study study NN cord-006608-mq4a4u40 77 4 of of IN cord-006608-mq4a4u40 77 5 266 266 CD cord-006608-mq4a4u40 77 6 health health NN cord-006608-mq4a4u40 77 7 care care NN cord-006608-mq4a4u40 77 8 workers worker NNS cord-006608-mq4a4u40 77 9 exposed expose VBN cord-006608-mq4a4u40 77 10 to to IN cord-006608-mq4a4u40 77 11 patients patient NNS cord-006608-mq4a4u40 77 12 , , , cord-006608-mq4a4u40 77 13 to to IN cord-006608-mq4a4u40 77 14 patients patient NNS cord-006608-mq4a4u40 77 15 ' ' POS cord-006608-mq4a4u40 77 16 body body NN cord-006608-mq4a4u40 77 17 fluids fluid NNS cord-006608-mq4a4u40 77 18 , , , cord-006608-mq4a4u40 77 19 or or CC cord-006608-mq4a4u40 77 20 to to IN cord-006608-mq4a4u40 77 21 laboratory laboratory NN cord-006608-mq4a4u40 77 22 specimens specimen NNS cord-006608-mq4a4u40 77 23 during during IN cord-006608-mq4a4u40 77 24 the the DT cord-006608-mq4a4u40 77 25 1993 1993 CD cord-006608-mq4a4u40 77 26 outbreak outbreak NN cord-006608-mq4a4u40 77 27 , , , cord-006608-mq4a4u40 77 28 serologic serologic NNP cord-006608-mq4a4u40 77 29 testing testing NN cord-006608-mq4a4u40 77 30 done do VBN cord-006608-mq4a4u40 77 31 within within IN cord-006608-mq4a4u40 77 32 6 6 CD cord-006608-mq4a4u40 77 33 weeks week NNS cord-006608-mq4a4u40 77 34 of of IN cord-006608-mq4a4u40 77 35 exposure exposure NN cord-006608-mq4a4u40 77 36 found find VBD cord-006608-mq4a4u40 77 37 no no DT cord-006608-mq4a4u40 77 38 evidence evidence NN cord-006608-mq4a4u40 77 39 of of IN cord-006608-mq4a4u40 77 40 infection infection NN cord-006608-mq4a4u40 77 41 [ [ -LRB- cord-006608-mq4a4u40 77 42 19 19 CD cord-006608-mq4a4u40 77 43 ] ] -RRB- cord-006608-mq4a4u40 77 44 . . . cord-006608-mq4a4u40 78 1 Serosurveys Serosurveys NNP cord-006608-mq4a4u40 78 2 performed perform VBD cord-006608-mq4a4u40 78 3 on on IN cord-006608-mq4a4u40 78 4 household household NN cord-006608-mq4a4u40 78 5 contacts contact NNS cord-006608-mq4a4u40 78 6 of of IN cord-006608-mq4a4u40 78 7 patients patient NNS cord-006608-mq4a4u40 78 8 with with IN cord-006608-mq4a4u40 78 9 HPS HPS NNP cord-006608-mq4a4u40 78 10 revealed reveal VBD cord-006608-mq4a4u40 78 11 no no DT cord-006608-mq4a4u40 78 12 IgM IgM NNP cord-006608-mq4a4u40 78 13 antibody antibody NN cord-006608-mq4a4u40 78 14 reactive reactive JJ cord-006608-mq4a4u40 78 15 with with IN cord-006608-mq4a4u40 78 16 SNV SNV NNP cord-006608-mq4a4u40 78 17 [ [ -LRB- cord-006608-mq4a4u40 78 18 20 20 CD cord-006608-mq4a4u40 78 19 ] ] -RRB- cord-006608-mq4a4u40 78 20 . . . cord-006608-mq4a4u40 79 1 Person person NN cord-006608-mq4a4u40 79 2 - - HYPH cord-006608-mq4a4u40 79 3 to to IN cord-006608-mq4a4u40 79 4 - - HYPH cord-006608-mq4a4u40 79 5 person person NN cord-006608-mq4a4u40 79 6 transmission transmission NN cord-006608-mq4a4u40 79 7 may may MD cord-006608-mq4a4u40 79 8 have have VB cord-006608-mq4a4u40 79 9 occurred occur VBN cord-006608-mq4a4u40 79 10 during during IN cord-006608-mq4a4u40 79 11 an an DT cord-006608-mq4a4u40 79 12 outbreak outbreak NN cord-006608-mq4a4u40 79 13 of of IN cord-006608-mq4a4u40 79 14 HPS hps NN cord-006608-mq4a4u40 79 15 caused cause VBN cord-006608-mq4a4u40 79 16 by by IN cord-006608-mq4a4u40 79 17 the the DT cord-006608-mq4a4u40 79 18 Andes Andes NNP cord-006608-mq4a4u40 79 19 virus virus NN cord-006608-mq4a4u40 79 20 in in IN cord-006608-mq4a4u40 79 21 El El NNP cord-006608-mq4a4u40 79 22 Bolson Bolson NNP cord-006608-mq4a4u40 79 23 , , , cord-006608-mq4a4u40 79 24 Argentina Argentina NNP cord-006608-mq4a4u40 79 25 , , , cord-006608-mq4a4u40 79 26 in in IN cord-006608-mq4a4u40 79 27 1996 1996 CD cord-006608-mq4a4u40 79 28 . . . cord-006608-mq4a4u40 80 1 Polymerase polymerase NN cord-006608-mq4a4u40 80 2 chain chain NN cord-006608-mq4a4u40 80 3 reaction reaction NN cord-006608-mq4a4u40 80 4 products product NNS cord-006608-mq4a4u40 80 5 of of IN cord-006608-mq4a4u40 80 6 partial partial JJ cord-006608-mq4a4u40 80 7 sequences sequence NNS cord-006608-mq4a4u40 80 8 of of IN cord-006608-mq4a4u40 80 9 M M NNP cord-006608-mq4a4u40 80 10 and and CC cord-006608-mq4a4u40 80 11 S S NNP cord-006608-mq4a4u40 80 12 viral viral JJ cord-006608-mq4a4u40 80 13 RNA RNA NNP cord-006608-mq4a4u40 80 14 segments segment NNS cord-006608-mq4a4u40 80 15 were be VBD cord-006608-mq4a4u40 80 16 studied study VBN cord-006608-mq4a4u40 80 17 from from IN cord-006608-mq4a4u40 80 18 clinical clinical JJ cord-006608-mq4a4u40 80 19 samples sample NNS cord-006608-mq4a4u40 80 20 to to TO cord-006608-mq4a4u40 80 21 assess assess VB cord-006608-mq4a4u40 80 22 homology homology NN cord-006608-mq4a4u40 80 23 . . . cord-006608-mq4a4u40 81 1 Samples sample NNS cord-006608-mq4a4u40 81 2 from from IN cord-006608-mq4a4u40 81 3 16 16 CD cord-006608-mq4a4u40 81 4 epidemiologically epidemiologically RB cord-006608-mq4a4u40 81 5 linked link VBN cord-006608-mq4a4u40 81 6 cases case NNS cord-006608-mq4a4u40 81 7 from from IN cord-006608-mq4a4u40 81 8 this this DT cord-006608-mq4a4u40 81 9 outbreak outbreak NN cord-006608-mq4a4u40 81 10 were be VBD cord-006608-mq4a4u40 81 11 ( ( -LRB- cord-006608-mq4a4u40 81 12 Fig Fig NNP cord-006608-mq4a4u40 81 13 . . . cord-006608-mq4a4u40 81 14 1 1 CD cord-006608-mq4a4u40 81 15 ) ) -RRB- cord-006608-mq4a4u40 82 1 and and CC cord-006608-mq4a4u40 82 2 in in IN cord-006608-mq4a4u40 82 3 Canada Canada NNP cord-006608-mq4a4u40 82 4 and and CC cord-006608-mq4a4u40 82 5 South South NNP cord-006608-mq4a4u40 82 6 America America NNP cord-006608-mq4a4u40 82 7 . . . cord-006608-mq4a4u40 83 1 The the DT cord-006608-mq4a4u40 83 2 overall overall JJ cord-006608-mq4a4u40 83 3 US US NNP cord-006608-mq4a4u40 83 4 mortality mortality NN cord-006608-mq4a4u40 83 5 rate rate NN cord-006608-mq4a4u40 83 6 is be VBZ cord-006608-mq4a4u40 83 7 38 38 CD cord-006608-mq4a4u40 83 8 % % NN cord-006608-mq4a4u40 83 9 , , , cord-006608-mq4a4u40 83 10 compared compare VBN cord-006608-mq4a4u40 83 11 with with IN cord-006608-mq4a4u40 83 12 52 52 CD cord-006608-mq4a4u40 83 13 % % NN cord-006608-mq4a4u40 83 14 in in IN cord-006608-mq4a4u40 83 15 the the DT cord-006608-mq4a4u40 83 16 first first JJ cord-006608-mq4a4u40 83 17 100 100 CD cord-006608-mq4a4u40 83 18 US US NNP cord-006608-mq4a4u40 83 19 cases case NNS cord-006608-mq4a4u40 83 20 [ [ -LRB- cord-006608-mq4a4u40 83 21 3 3 CD cord-006608-mq4a4u40 83 22 ] ] -RRB- cord-006608-mq4a4u40 83 23 ( ( -LRB- cord-006608-mq4a4u40 83 24 Table table NN cord-006608-mq4a4u40 83 25 3 3 CD cord-006608-mq4a4u40 83 26 ) ) -RRB- cord-006608-mq4a4u40 83 27 . . . cord-006608-mq4a4u40 84 1 The the DT cord-006608-mq4a4u40 84 2 mean mean JJ cord-006608-mq4a4u40 84 3 patient patient JJ cord-006608-mq4a4u40 84 4 age age NN cord-006608-mq4a4u40 84 5 is be VBZ cord-006608-mq4a4u40 84 6 38 38 CD cord-006608-mq4a4u40 84 7 years year NNS cord-006608-mq4a4u40 84 8 . . . cord-006608-mq4a4u40 85 1 Men man NNS cord-006608-mq4a4u40 85 2 make make VBP cord-006608-mq4a4u40 85 3 up up RP cord-006608-mq4a4u40 85 4 59 59 CD cord-006608-mq4a4u40 85 5 % % NN cord-006608-mq4a4u40 85 6 of of IN cord-006608-mq4a4u40 85 7 the the DT cord-006608-mq4a4u40 85 8 total total JJ cord-006608-mq4a4u40 85 9 cases case NNS cord-006608-mq4a4u40 85 10 . . . cord-006608-mq4a4u40 86 1 Caucasians Caucasians NNPS cord-006608-mq4a4u40 86 2 account account VBP cord-006608-mq4a4u40 86 3 for for IN cord-006608-mq4a4u40 86 4 77 77 CD cord-006608-mq4a4u40 86 5 % % NN cord-006608-mq4a4u40 86 6 of of IN cord-006608-mq4a4u40 86 7 cases case NNS cord-006608-mq4a4u40 86 8 , , , cord-006608-mq4a4u40 86 9 and and CC cord-006608-mq4a4u40 86 10 Native Native NNP cord-006608-mq4a4u40 86 11 Americans Americans NNPS cord-006608-mq4a4u40 86 12 for for IN cord-006608-mq4a4u40 86 13 20 20 CD cord-006608-mq4a4u40 86 14 % % NN cord-006608-mq4a4u40 86 15 . . . cord-006608-mq4a4u40 87 1 Three three CD cord-006608-mq4a4u40 87 2 quarters quarter NNS cord-006608-mq4a4u40 87 3 of of IN cord-006608-mq4a4u40 87 4 the the DT cord-006608-mq4a4u40 87 5 cases case NNS cord-006608-mq4a4u40 87 6 come come VBP cord-006608-mq4a4u40 87 7 from from IN cord-006608-mq4a4u40 87 8 rural rural JJ cord-006608-mq4a4u40 87 9 areas area NNS cord-006608-mq4a4u40 87 10 . . . cord-006608-mq4a4u40 88 1 Children child NNS cord-006608-mq4a4u40 88 2 represent represent VBP cord-006608-mq4a4u40 88 3 few few JJ cord-006608-mq4a4u40 88 4 cases case NNS cord-006608-mq4a4u40 88 5 of of IN cord-006608-mq4a4u40 88 6 HPS hps NN cord-006608-mq4a4u40 88 7 in in IN cord-006608-mq4a4u40 88 8 the the DT cord-006608-mq4a4u40 88 9 United United NNP cord-006608-mq4a4u40 88 10 States States NNP cord-006608-mq4a4u40 88 11 but but CC cord-006608-mq4a4u40 88 12 account account VBP cord-006608-mq4a4u40 88 13 for for IN cord-006608-mq4a4u40 88 14 a a DT cord-006608-mq4a4u40 88 15 larger large JJR cord-006608-mq4a4u40 88 16 proportion proportion NN cord-006608-mq4a4u40 88 17 of of IN cord-006608-mq4a4u40 88 18 cases case NNS cord-006608-mq4a4u40 88 19 in in IN cord-006608-mq4a4u40 88 20 South South NNP cord-006608-mq4a4u40 88 21 America America NNP cord-006608-mq4a4u40 88 22 [ [ -LRB- cord-006608-mq4a4u40 88 23 23 23 CD cord-006608-mq4a4u40 88 24 ] ] -RRB- cord-006608-mq4a4u40 88 25 . . . cord-006608-mq4a4u40 89 1 After after IN cord-006608-mq4a4u40 89 2 the the DT cord-006608-mq4a4u40 89 3 1993 1993 CD cord-006608-mq4a4u40 89 4 Four four CD cord-006608-mq4a4u40 89 5 Corners Corners NNPS cord-006608-mq4a4u40 89 6 outbreak outbreak NN cord-006608-mq4a4u40 89 7 , , , cord-006608-mq4a4u40 89 8 a a DT cord-006608-mq4a4u40 89 9 serosurvey serosurvey NN cord-006608-mq4a4u40 89 10 was be VBD cord-006608-mq4a4u40 89 11 done do VBN cord-006608-mq4a4u40 89 12 to to TO cord-006608-mq4a4u40 89 13 identify identify VB cord-006608-mq4a4u40 89 14 milder mild JJR cord-006608-mq4a4u40 89 15 , , , cord-006608-mq4a4u40 89 16 unreported unreported JJ cord-006608-mq4a4u40 89 17 cases case NNS cord-006608-mq4a4u40 89 18 . . . cord-006608-mq4a4u40 90 1 Outpatients outpatient NNS cord-006608-mq4a4u40 90 2 presenting present VBG cord-006608-mq4a4u40 90 3 with with IN cord-006608-mq4a4u40 90 4 a a DT cord-006608-mq4a4u40 90 5 syndrome syndrome NN cord-006608-mq4a4u40 90 6 of of IN cord-006608-mq4a4u40 90 7 fevers fever NNS cord-006608-mq4a4u40 90 8 and and CC cord-006608-mq4a4u40 90 9 myalgias myalgia NNS cord-006608-mq4a4u40 90 10 resembling resemble VBG cord-006608-mq4a4u40 90 11 the the DT cord-006608-mq4a4u40 90 12 HPS HPS NNP cord-006608-mq4a4u40 90 13 prodrome prodrome NN cord-006608-mq4a4u40 90 14 were be VBD cord-006608-mq4a4u40 90 15 surveyed survey VBN cord-006608-mq4a4u40 90 16 ; ; : cord-006608-mq4a4u40 90 17 no no DT cord-006608-mq4a4u40 90 18 patient patient NN cord-006608-mq4a4u40 90 19 had have VBD cord-006608-mq4a4u40 90 20 IgM IgM NNP cord-006608-mq4a4u40 90 21 antibody antibody NNP cord-006608-mq4a4u40 90 22 reactive reactive JJ cord-006608-mq4a4u40 90 23 with with IN cord-006608-mq4a4u40 90 24 SNV SNV NNP cord-006608-mq4a4u40 90 25 [ [ -LRB- cord-006608-mq4a4u40 90 26 24 24 CD cord-006608-mq4a4u40 90 27 ] ] -RRB- cord-006608-mq4a4u40 90 28 . . . cord-006608-mq4a4u40 91 1 Recently recently RB cord-006608-mq4a4u40 91 2 however however RB cord-006608-mq4a4u40 91 3 , , , cord-006608-mq4a4u40 91 4 five five CD cord-006608-mq4a4u40 91 5 cases case NNS cord-006608-mq4a4u40 91 6 of of IN cord-006608-mq4a4u40 91 7 acute acute JJ cord-006608-mq4a4u40 91 8 SNV SNV NNP cord-006608-mq4a4u40 91 9 infection infection NN cord-006608-mq4a4u40 91 10 documented document VBN cord-006608-mq4a4u40 91 11 by by IN cord-006608-mq4a4u40 91 12 serology serology NN cord-006608-mq4a4u40 91 13 were be VBD cord-006608-mq4a4u40 91 14 identified identify VBN cord-006608-mq4a4u40 91 15 , , , cord-006608-mq4a4u40 91 16 with with IN cord-006608-mq4a4u40 91 17 a a DT cord-006608-mq4a4u40 91 18 clinical clinical JJ cord-006608-mq4a4u40 91 19 illness illness NN cord-006608-mq4a4u40 91 20 less less RBR cord-006608-mq4a4u40 91 21 severe severe JJ cord-006608-mq4a4u40 91 22 than than IN cord-006608-mq4a4u40 91 23 HPS HPS NNP cord-006608-mq4a4u40 91 24 [ [ -LRB- cord-006608-mq4a4u40 91 25 25• 25• CD cord-006608-mq4a4u40 91 26 ] ] -RRB- cord-006608-mq4a4u40 91 27 . . . cord-006608-mq4a4u40 92 1 Several several JJ cord-006608-mq4a4u40 92 2 mild mild JJ cord-006608-mq4a4u40 92 3 and and CC cord-006608-mq4a4u40 92 4 even even RB cord-006608-mq4a4u40 92 5 asymptomatic asymptomatic JJ cord-006608-mq4a4u40 92 6 cases case NNS cord-006608-mq4a4u40 92 7 of of IN cord-006608-mq4a4u40 92 8 HPS HPS NNP cord-006608-mq4a4u40 92 9 have have VBP cord-006608-mq4a4u40 92 10 also also RB cord-006608-mq4a4u40 92 11 been be VBN cord-006608-mq4a4u40 92 12 reported report VBN cord-006608-mq4a4u40 92 13 in in IN cord-006608-mq4a4u40 92 14 South South NNP cord-006608-mq4a4u40 92 15 America America NNP cord-006608-mq4a4u40 92 16 [ [ -LRB- cord-006608-mq4a4u40 92 17 23 23 CD cord-006608-mq4a4u40 92 18 ] ] -RRB- cord-006608-mq4a4u40 92 19 . . . cord-006608-mq4a4u40 93 1 Risk risk NN cord-006608-mq4a4u40 93 2 factors factor NNS cord-006608-mq4a4u40 93 3 for for IN cord-006608-mq4a4u40 93 4 HPS hps NN cord-006608-mq4a4u40 93 5 identified identify VBN cord-006608-mq4a4u40 93 6 from from IN cord-006608-mq4a4u40 93 7 a a DT cord-006608-mq4a4u40 93 8 case case NN cord-006608-mq4a4u40 93 9 - - HYPH cord-006608-mq4a4u40 93 10 control control NN cord-006608-mq4a4u40 93 11 study study NN cord-006608-mq4a4u40 93 12 during during IN cord-006608-mq4a4u40 93 13 the the DT cord-006608-mq4a4u40 93 14 1993 1993 CD cord-006608-mq4a4u40 93 15 outbreak outbreak NN cord-006608-mq4a4u40 93 16 included include VBD cord-006608-mq4a4u40 93 17 peridomestic peridomestic JJ cord-006608-mq4a4u40 93 18 cleaning cleaning NN cord-006608-mq4a4u40 93 19 or or CC cord-006608-mq4a4u40 93 20 agricultural agricultural JJ cord-006608-mq4a4u40 93 21 activities activity NNS cord-006608-mq4a4u40 93 22 . . . cord-006608-mq4a4u40 94 1 More More JJR cord-006608-mq4a4u40 94 2 rodents rodent NNS cord-006608-mq4a4u40 94 3 were be VBD cord-006608-mq4a4u40 94 4 trapped trap VBN cord-006608-mq4a4u40 94 5 around around IN cord-006608-mq4a4u40 94 6 the the DT cord-006608-mq4a4u40 94 7 homes home NNS cord-006608-mq4a4u40 94 8 of of IN cord-006608-mq4a4u40 94 9 case case NN cord-006608-mq4a4u40 94 10 patients patient NNS cord-006608-mq4a4u40 94 11 than than IN cord-006608-mq4a4u40 94 12 the the DT cord-006608-mq4a4u40 94 13 homes home NNS cord-006608-mq4a4u40 94 14 of of IN cord-006608-mq4a4u40 94 15 controls control NNS cord-006608-mq4a4u40 94 16 [ [ -LRB- cord-006608-mq4a4u40 94 17 20 20 CD cord-006608-mq4a4u40 94 18 ] ] -RRB- cord-006608-mq4a4u40 94 19 . . . cord-006608-mq4a4u40 95 1 The the DT cord-006608-mq4a4u40 95 2 clinical clinical JJ cord-006608-mq4a4u40 95 3 manifestations manifestation NNS cord-006608-mq4a4u40 95 4 of of IN cord-006608-mq4a4u40 95 5 HPS HPS NNP cord-006608-mq4a4u40 95 6 can can MD cord-006608-mq4a4u40 95 7 be be VB cord-006608-mq4a4u40 95 8 divided divide VBN cord-006608-mq4a4u40 95 9 into into IN cord-006608-mq4a4u40 95 10 prodromal prodromal JJ cord-006608-mq4a4u40 95 11 , , , cord-006608-mq4a4u40 95 12 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 95 13 , , , cord-006608-mq4a4u40 95 14 and and CC cord-006608-mq4a4u40 95 15 convalescent convalescent JJ cord-006608-mq4a4u40 95 16 phases phase NNS cord-006608-mq4a4u40 95 17 ( ( -LRB- cord-006608-mq4a4u40 95 18 Fig Fig NNP cord-006608-mq4a4u40 95 19 . . . cord-006608-mq4a4u40 95 20 _SP cord-006608-mq4a4u40 95 21 2 2 CD cord-006608-mq4a4u40 95 22 ) ) -RRB- cord-006608-mq4a4u40 95 23 . . . cord-006608-mq4a4u40 96 1 In in IN cord-006608-mq4a4u40 96 2 the the DT cord-006608-mq4a4u40 96 3 prodromal prodromal JJ cord-006608-mq4a4u40 96 4 stage stage NN cord-006608-mq4a4u40 96 5 , , , cord-006608-mq4a4u40 96 6 which which WDT cord-006608-mq4a4u40 96 7 usually usually RB cord-006608-mq4a4u40 96 8 lasts last VBZ cord-006608-mq4a4u40 96 9 3 3 CD cord-006608-mq4a4u40 96 10 to to TO cord-006608-mq4a4u40 96 11 6 6 CD cord-006608-mq4a4u40 96 12 days day NNS cord-006608-mq4a4u40 96 13 , , , cord-006608-mq4a4u40 96 14 the the DT cord-006608-mq4a4u40 96 15 most most RBS cord-006608-mq4a4u40 96 16 frequent frequent JJ cord-006608-mq4a4u40 96 17 symptoms symptom NNS cord-006608-mq4a4u40 96 18 are be VBP cord-006608-mq4a4u40 96 19 fever fever NN cord-006608-mq4a4u40 96 20 , , , cord-006608-mq4a4u40 96 21 chills chill NNS cord-006608-mq4a4u40 96 22 , , , cord-006608-mq4a4u40 96 23 and and CC cord-006608-mq4a4u40 96 24 myalgias myalgias NNP cord-006608-mq4a4u40 96 25 . . . cord-006608-mq4a4u40 97 1 Abdominal abdominal JJ cord-006608-mq4a4u40 97 2 pain pain NN cord-006608-mq4a4u40 97 3 , , , cord-006608-mq4a4u40 97 4 nausea nausea NN cord-006608-mq4a4u40 97 5 , , , cord-006608-mq4a4u40 97 6 vomiting vomiting NN cord-006608-mq4a4u40 97 7 , , , cord-006608-mq4a4u40 97 8 headache headache NN cord-006608-mq4a4u40 97 9 , , , cord-006608-mq4a4u40 97 10 and and CC cord-006608-mq4a4u40 97 11 dizziness dizziness NN cord-006608-mq4a4u40 97 12 may may MD cord-006608-mq4a4u40 97 13 occur occur VB cord-006608-mq4a4u40 97 14 . . . cord-006608-mq4a4u40 98 1 Respiratory respiratory JJ cord-006608-mq4a4u40 98 2 symptoms symptom NNS cord-006608-mq4a4u40 98 3 are be VBP cord-006608-mq4a4u40 98 4 often often RB cord-006608-mq4a4u40 98 5 absent absent JJ cord-006608-mq4a4u40 98 6 . . . cord-006608-mq4a4u40 99 1 Sore Sore NNP cord-006608-mq4a4u40 99 2 throat throat NN cord-006608-mq4a4u40 99 3 , , , cord-006608-mq4a4u40 99 4 coryza coryza NNP cord-006608-mq4a4u40 99 5 , , , cord-006608-mq4a4u40 99 6 and and CC cord-006608-mq4a4u40 99 7 meningismus meningismus NNP cord-006608-mq4a4u40 99 8 are be VBP cord-006608-mq4a4u40 99 9 uncommon uncommon JJ cord-006608-mq4a4u40 99 10 , , , cord-006608-mq4a4u40 99 11 and and CC cord-006608-mq4a4u40 99 12 their -PRON- PRP$ cord-006608-mq4a4u40 99 13 presence presence NN cord-006608-mq4a4u40 99 14 may may MD cord-006608-mq4a4u40 99 15 be be VB cord-006608-mq4a4u40 99 16 useful useful JJ cord-006608-mq4a4u40 99 17 in in IN cord-006608-mq4a4u40 99 18 differentiating differentiate VBG cord-006608-mq4a4u40 99 19 HPS hps NN cord-006608-mq4a4u40 99 20 from from IN cord-006608-mq4a4u40 99 21 other other JJ cord-006608-mq4a4u40 99 22 viral viral JJ cord-006608-mq4a4u40 99 23 infections infection NNS cord-006608-mq4a4u40 99 24 . . . cord-006608-mq4a4u40 100 1 Physical physical JJ cord-006608-mq4a4u40 100 2 examination examination NN cord-006608-mq4a4u40 100 3 , , , cord-006608-mq4a4u40 100 4 laboratory laboratory NN cord-006608-mq4a4u40 100 5 data datum NNS cord-006608-mq4a4u40 100 6 , , , cord-006608-mq4a4u40 100 7 and and CC cord-006608-mq4a4u40 100 8 chest chest NN cord-006608-mq4a4u40 100 9 radiographs radiograph NNS cord-006608-mq4a4u40 100 10 may may MD cord-006608-mq4a4u40 100 11 be be VB cord-006608-mq4a4u40 100 12 normal normal JJ cord-006608-mq4a4u40 100 13 in in IN cord-006608-mq4a4u40 100 14 this this DT cord-006608-mq4a4u40 100 15 stage stage NN cord-006608-mq4a4u40 100 16 . . . cord-006608-mq4a4u40 101 1 The the DT cord-006608-mq4a4u40 101 2 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 101 3 stage stage NN cord-006608-mq4a4u40 101 4 , , , cord-006608-mq4a4u40 101 5 heralded herald VBN cord-006608-mq4a4u40 101 6 by by IN cord-006608-mq4a4u40 101 7 cough cough NN cord-006608-mq4a4u40 101 8 and and CC cord-006608-mq4a4u40 101 9 dyspnea dyspnea NN cord-006608-mq4a4u40 101 10 , , , cord-006608-mq4a4u40 101 11 can can MD cord-006608-mq4a4u40 101 12 progress progress VB cord-006608-mq4a4u40 101 13 rapidly rapidly RB cord-006608-mq4a4u40 101 14 ; ; : cord-006608-mq4a4u40 101 15 pulmonary pulmonary JJ cord-006608-mq4a4u40 101 16 edema edema NN cord-006608-mq4a4u40 101 17 and and CC cord-006608-mq4a4u40 101 18 respiratory respiratory JJ cord-006608-mq4a4u40 101 19 failure failure NN cord-006608-mq4a4u40 101 20 may may MD cord-006608-mq4a4u40 101 21 develop develop VB cord-006608-mq4a4u40 101 22 within within IN cord-006608-mq4a4u40 101 23 hours hour NNS cord-006608-mq4a4u40 101 24 of of IN cord-006608-mq4a4u40 101 25 presentation presentation NN cord-006608-mq4a4u40 101 26 . . . cord-006608-mq4a4u40 102 1 Physical physical JJ cord-006608-mq4a4u40 102 2 examination examination NN cord-006608-mq4a4u40 102 3 is be VBZ cord-006608-mq4a4u40 102 4 notable notable JJ cord-006608-mq4a4u40 102 5 for for IN cord-006608-mq4a4u40 102 6 tachypnea tachypnea NNP cord-006608-mq4a4u40 102 7 , , , cord-006608-mq4a4u40 102 8 tachycardia tachycardia NN cord-006608-mq4a4u40 102 9 , , , cord-006608-mq4a4u40 102 10 and and CC cord-006608-mq4a4u40 102 11 hypotension hypotension NN cord-006608-mq4a4u40 102 12 . . . cord-006608-mq4a4u40 103 1 Chest chest NN cord-006608-mq4a4u40 103 2 radiographs radiograph NNS cord-006608-mq4a4u40 103 3 usually usually RB cord-006608-mq4a4u40 103 4 show show VBP cord-006608-mq4a4u40 103 5 interstitial interstitial JJ cord-006608-mq4a4u40 103 6 edema edema NN cord-006608-mq4a4u40 103 7 and and CC cord-006608-mq4a4u40 103 8 basilar basilar JJ cord-006608-mq4a4u40 103 9 or or CC cord-006608-mq4a4u40 103 10 central central JJ cord-006608-mq4a4u40 103 11 air air NN cord-006608-mq4a4u40 103 12 space space NN cord-006608-mq4a4u40 103 13 disease disease NN cord-006608-mq4a4u40 103 14 . . . cord-006608-mq4a4u40 104 1 These these DT cord-006608-mq4a4u40 104 2 findings finding NNS cord-006608-mq4a4u40 104 3 contrast contrast NN cord-006608-mq4a4u40 104 4 with with IN cord-006608-mq4a4u40 104 5 those those DT cord-006608-mq4a4u40 104 6 for for IN cord-006608-mq4a4u40 104 7 acute acute JJ cord-006608-mq4a4u40 104 8 respiratory respiratory JJ cord-006608-mq4a4u40 104 9 distress distress NN cord-006608-mq4a4u40 104 10 syndrome syndrome NN cord-006608-mq4a4u40 104 11 ( ( -LRB- cord-006608-mq4a4u40 104 12 ARDS ARDS NNP cord-006608-mq4a4u40 104 13 ) ) -RRB- cord-006608-mq4a4u40 104 14 , , , cord-006608-mq4a4u40 104 15 in in IN cord-006608-mq4a4u40 104 16 which which WDT cord-006608-mq4a4u40 104 17 interstitial interstitial JJ cord-006608-mq4a4u40 104 18 edema edema NN cord-006608-mq4a4u40 104 19 is be VBZ cord-006608-mq4a4u40 104 20 rare rare JJ cord-006608-mq4a4u40 104 21 and and CC cord-006608-mq4a4u40 104 22 air air NN cord-006608-mq4a4u40 104 23 space space NN cord-006608-mq4a4u40 104 24 disease disease NN cord-006608-mq4a4u40 104 25 is be VBZ cord-006608-mq4a4u40 104 26 usually usually RB cord-006608-mq4a4u40 104 27 peripherally peripherally RB cord-006608-mq4a4u40 104 28 distributed distribute VBN cord-006608-mq4a4u40 104 29 early early RB cord-006608-mq4a4u40 104 30 in in IN cord-006608-mq4a4u40 104 31 the the DT cord-006608-mq4a4u40 104 32 course course NN cord-006608-mq4a4u40 104 33 . . . cord-006608-mq4a4u40 105 1 Hemodynamic Hemodynamic NNP cord-006608-mq4a4u40 105 2 measures measure NNS cord-006608-mq4a4u40 105 3 are be VBP cord-006608-mq4a4u40 105 4 characterized characterize VBN cord-006608-mq4a4u40 105 5 by by IN cord-006608-mq4a4u40 105 6 low low JJ cord-006608-mq4a4u40 105 7 initial initial JJ cord-006608-mq4a4u40 105 8 pulmonary pulmonary JJ cord-006608-mq4a4u40 105 9 artery artery NN cord-006608-mq4a4u40 105 10 occlusion occlusion NN cord-006608-mq4a4u40 105 11 pressure pressure NN cord-006608-mq4a4u40 105 12 , , , cord-006608-mq4a4u40 105 13 high high JJ cord-006608-mq4a4u40 105 14 systemic systemic JJ cord-006608-mq4a4u40 105 15 vascular vascular JJ cord-006608-mq4a4u40 105 16 resistance resistance NN cord-006608-mq4a4u40 105 17 , , , cord-006608-mq4a4u40 105 18 and and CC cord-006608-mq4a4u40 105 19 depressed depressed JJ cord-006608-mq4a4u40 105 20 cardiac cardiac JJ cord-006608-mq4a4u40 105 21 output output NN cord-006608-mq4a4u40 105 22 , , , cord-006608-mq4a4u40 105 23 consistent consistent JJ cord-006608-mq4a4u40 105 24 with with IN cord-006608-mq4a4u40 105 25 a a DT cord-006608-mq4a4u40 105 26 noncardiac noncardiac JJ cord-006608-mq4a4u40 105 27 cause cause NN cord-006608-mq4a4u40 105 28 of of IN cord-006608-mq4a4u40 105 29 pulmonary pulmonary JJ cord-006608-mq4a4u40 105 30 edema edema NN cord-006608-mq4a4u40 105 31 [ [ -LRB- cord-006608-mq4a4u40 105 32 26 26 CD cord-006608-mq4a4u40 105 33 ] ] -RRB- cord-006608-mq4a4u40 105 34 . . . cord-006608-mq4a4u40 106 1 Pleural Pleural NNP cord-006608-mq4a4u40 106 2 effusions effusion NNS cord-006608-mq4a4u40 106 3 may may MD cord-006608-mq4a4u40 106 4 occur occur VB cord-006608-mq4a4u40 106 5 in in IN cord-006608-mq4a4u40 106 6 up up IN cord-006608-mq4a4u40 106 7 to to TO cord-006608-mq4a4u40 106 8 78 78 CD cord-006608-mq4a4u40 106 9 % % NN cord-006608-mq4a4u40 106 10 of of IN cord-006608-mq4a4u40 106 11 patients patient NNS cord-006608-mq4a4u40 106 12 [ [ -LRB- cord-006608-mq4a4u40 106 13 27 27 CD cord-006608-mq4a4u40 106 14 ] ] -RRB- cord-006608-mq4a4u40 106 15 . . . cord-006608-mq4a4u40 107 1 The the DT cord-006608-mq4a4u40 107 2 pleural pleural JJ cord-006608-mq4a4u40 107 3 fluid fluid NN cord-006608-mq4a4u40 107 4 is be VBZ cord-006608-mq4a4u40 107 5 initially initially RB cord-006608-mq4a4u40 107 6 transudative transudative JJ cord-006608-mq4a4u40 107 7 but but CC cord-006608-mq4a4u40 107 8 may may MD cord-006608-mq4a4u40 107 9 become become VB cord-006608-mq4a4u40 107 10 exudative exudative JJ cord-006608-mq4a4u40 107 11 during during IN cord-006608-mq4a4u40 107 12 recovery recovery NN cord-006608-mq4a4u40 107 13 because because IN cord-006608-mq4a4u40 107 14 fluid fluid JJ cord-006608-mq4a4u40 107 15 shifts shift NNS cord-006608-mq4a4u40 107 16 as as IN cord-006608-mq4a4u40 107 17 cardiac cardiac JJ cord-006608-mq4a4u40 107 18 function function NN cord-006608-mq4a4u40 107 19 normalizes normalize VBZ cord-006608-mq4a4u40 107 20 . . . cord-006608-mq4a4u40 108 1 Severe severe JJ cord-006608-mq4a4u40 108 2 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 108 3 dysfunction dysfunction NN cord-006608-mq4a4u40 108 4 appears appear VBZ cord-006608-mq4a4u40 108 5 to to TO cord-006608-mq4a4u40 108 6 predict predict VB cord-006608-mq4a4u40 108 7 a a DT cord-006608-mq4a4u40 108 8 poor poor JJ cord-006608-mq4a4u40 108 9 prognosis prognosis NN cord-006608-mq4a4u40 108 10 . . . cord-006608-mq4a4u40 109 1 In in IN cord-006608-mq4a4u40 109 2 fatal fatal JJ cord-006608-mq4a4u40 109 3 cases case NNS cord-006608-mq4a4u40 109 4 , , , cord-006608-mq4a4u40 109 5 the the DT cord-006608-mq4a4u40 109 6 cardiac cardiac JJ cord-006608-mq4a4u40 109 7 index index NN cord-006608-mq4a4u40 109 8 progressively progressively RB cord-006608-mq4a4u40 109 9 decreases decrease VBZ cord-006608-mq4a4u40 109 10 , , , cord-006608-mq4a4u40 109 11 with with IN cord-006608-mq4a4u40 109 12 severe severe JJ cord-006608-mq4a4u40 109 13 oxygen oxygen NN cord-006608-mq4a4u40 109 14 debt debt NN cord-006608-mq4a4u40 109 15 and and CC cord-006608-mq4a4u40 109 16 elevated elevated JJ cord-006608-mq4a4u40 109 17 lactate lactate NN cord-006608-mq4a4u40 109 18 levels level NNS cord-006608-mq4a4u40 109 19 . . . cord-006608-mq4a4u40 110 1 Survivors survivor NNS cord-006608-mq4a4u40 110 2 can can MD cord-006608-mq4a4u40 110 3 be be VB cord-006608-mq4a4u40 110 4 extubated extubate VBN cord-006608-mq4a4u40 110 5 as as RB cord-006608-mq4a4u40 110 6 early early RB cord-006608-mq4a4u40 110 7 as as IN cord-006608-mq4a4u40 110 8 24 24 CD cord-006608-mq4a4u40 110 9 to to TO cord-006608-mq4a4u40 110 10 48 48 CD cord-006608-mq4a4u40 110 11 hours hour NNS cord-006608-mq4a4u40 110 12 , , , cord-006608-mq4a4u40 110 13 but but CC cord-006608-mq4a4u40 110 14 extubation extubation NN cord-006608-mq4a4u40 110 15 generally generally RB cord-006608-mq4a4u40 110 16 takes take VBZ cord-006608-mq4a4u40 110 17 place place NN cord-006608-mq4a4u40 110 18 between between IN cord-006608-mq4a4u40 110 19 4 4 CD cord-006608-mq4a4u40 110 20 and and CC cord-006608-mq4a4u40 110 21 6 6 CD cord-006608-mq4a4u40 110 22 days day NNS cord-006608-mq4a4u40 110 23 . . . cord-006608-mq4a4u40 111 1 The the DT cord-006608-mq4a4u40 111 2 classic classic JJ cord-006608-mq4a4u40 111 3 laboratory laboratory NN cord-006608-mq4a4u40 111 4 findings finding NNS cord-006608-mq4a4u40 111 5 in in IN cord-006608-mq4a4u40 111 6 HPS HPS NNP cord-006608-mq4a4u40 111 7 are be VBP cord-006608-mq4a4u40 111 8 hemoconcentration hemoconcentration NN cord-006608-mq4a4u40 111 9 and and CC cord-006608-mq4a4u40 111 10 thrombocytopenia thrombocytopenia NN cord-006608-mq4a4u40 111 11 . . . cord-006608-mq4a4u40 112 1 Other other JJ cord-006608-mq4a4u40 112 2 laboratory laboratory NN cord-006608-mq4a4u40 112 3 findings finding NNS cord-006608-mq4a4u40 112 4 are be VBP cord-006608-mq4a4u40 112 5 leukocytosis leukocytosis NNP cord-006608-mq4a4u40 112 6 , , , cord-006608-mq4a4u40 112 7 with with IN cord-006608-mq4a4u40 112 8 a a DT cord-006608-mq4a4u40 112 9 left left JJ cord-006608-mq4a4u40 112 10 shift shift NN cord-006608-mq4a4u40 112 11 and and CC cord-006608-mq4a4u40 112 12 atypical atypical JJ cord-006608-mq4a4u40 112 13 lymphocytosis lymphocytosis NN cord-006608-mq4a4u40 112 14 ; ; , cord-006608-mq4a4u40 112 15 elevated elevated JJ cord-006608-mq4a4u40 112 16 coagulation coagulation NN cord-006608-mq4a4u40 112 17 indices index NNS cord-006608-mq4a4u40 112 18 ( ( -LRB- cord-006608-mq4a4u40 112 19 disseminated disseminate VBN cord-006608-mq4a4u40 112 20 intravascular intravascular JJ cord-006608-mq4a4u40 112 21 coagulation coagulation NN cord-006608-mq4a4u40 112 22 is be VBZ cord-006608-mq4a4u40 112 23 uncommon uncommon JJ cord-006608-mq4a4u40 112 24 ) ) -RRB- cord-006608-mq4a4u40 112 25 ; ; : cord-006608-mq4a4u40 112 26 and and CC cord-006608-mq4a4u40 112 27 elevated elevated JJ cord-006608-mq4a4u40 112 28 aminotransferase aminotransferase NN cord-006608-mq4a4u40 112 29 levels level NNS cord-006608-mq4a4u40 112 30 . . . cord-006608-mq4a4u40 113 1 Serum serum NN cord-006608-mq4a4u40 113 2 creatinine creatinine NN cord-006608-mq4a4u40 113 3 levels level NNS cord-006608-mq4a4u40 113 4 can can MD cord-006608-mq4a4u40 113 5 be be VB cord-006608-mq4a4u40 113 6 elevated elevate VBN cord-006608-mq4a4u40 113 7 ( ( -LRB- cord-006608-mq4a4u40 113 8 < < NNP cord-006608-mq4a4u40 113 9 2.5 2.5 CD cord-006608-mq4a4u40 113 10 mg mg NNP cord-006608-mq4a4u40 113 11 / / SYM cord-006608-mq4a4u40 113 12 dL dl NN cord-006608-mq4a4u40 113 13 ) ) -RRB- cord-006608-mq4a4u40 113 14 in in IN cord-006608-mq4a4u40 113 15 severe severe JJ cord-006608-mq4a4u40 113 16 cases case NNS cord-006608-mq4a4u40 113 17 , , , cord-006608-mq4a4u40 113 18 but but CC cord-006608-mq4a4u40 113 19 frank frank JJ cord-006608-mq4a4u40 113 20 renal renal JJ cord-006608-mq4a4u40 113 21 failure failure NN cord-006608-mq4a4u40 113 22 is be VBZ cord-006608-mq4a4u40 113 23 uncommon uncommon JJ cord-006608-mq4a4u40 113 24 . . . cord-006608-mq4a4u40 114 1 Metabolic metabolic JJ cord-006608-mq4a4u40 114 2 acidosis acidosis NN cord-006608-mq4a4u40 114 3 with with IN cord-006608-mq4a4u40 114 4 lactic lactic JJ cord-006608-mq4a4u40 114 5 acidemia acidemia NN cord-006608-mq4a4u40 114 6 can can MD cord-006608-mq4a4u40 114 7 be be VB cord-006608-mq4a4u40 114 8 seen see VBN cord-006608-mq4a4u40 114 9 in in IN cord-006608-mq4a4u40 114 10 severe severe JJ cord-006608-mq4a4u40 114 11 cases case NNS cord-006608-mq4a4u40 114 12 . . . cord-006608-mq4a4u40 115 1 Moolenaar Moolenaar NNP cord-006608-mq4a4u40 115 2 et et FW cord-006608-mq4a4u40 115 3 al al NNP cord-006608-mq4a4u40 115 4 . . . cord-006608-mq4a4u40 116 1 [ [ -LRB- cord-006608-mq4a4u40 116 2 28 28 CD cord-006608-mq4a4u40 116 3 ] ] -RRB- cord-006608-mq4a4u40 116 4 compared compare VBD cord-006608-mq4a4u40 116 5 the the DT cord-006608-mq4a4u40 116 6 clinical clinical JJ cord-006608-mq4a4u40 116 7 and and CC cord-006608-mq4a4u40 116 8 laboratory laboratory NN cord-006608-mq4a4u40 116 9 characteristics characteristic NNS cord-006608-mq4a4u40 116 10 of of IN cord-006608-mq4a4u40 116 11 patients patient NNS cord-006608-mq4a4u40 116 12 with with IN cord-006608-mq4a4u40 116 13 HPS hps NN cord-006608-mq4a4u40 116 14 with with IN cord-006608-mq4a4u40 116 15 those those DT cord-006608-mq4a4u40 116 16 of of IN cord-006608-mq4a4u40 116 17 patients patient NNS cord-006608-mq4a4u40 116 18 with with IN cord-006608-mq4a4u40 116 19 bacteremic bacteremic JJ cord-006608-mq4a4u40 116 20 pneumococcal pneumococcal JJ cord-006608-mq4a4u40 116 21 pneumonia pneumonia NN cord-006608-mq4a4u40 116 22 , , , cord-006608-mq4a4u40 116 23 influenza influenza NN cord-006608-mq4a4u40 116 24 , , , cord-006608-mq4a4u40 116 25 and and CC cord-006608-mq4a4u40 116 26 unexplained unexplained JJ cord-006608-mq4a4u40 116 27 ARDS ARDS NNP cord-006608-mq4a4u40 116 28 . . . cord-006608-mq4a4u40 117 1 The the DT cord-006608-mq4a4u40 117 2 presence presence NN cord-006608-mq4a4u40 117 3 on on IN cord-006608-mq4a4u40 117 4 hospital hospital NN cord-006608-mq4a4u40 117 5 admission admission NN cord-006608-mq4a4u40 117 6 of of IN cord-006608-mq4a4u40 117 7 dizziness dizziness NN cord-006608-mq4a4u40 117 8 , , , cord-006608-mq4a4u40 117 9 nausea nausea NN cord-006608-mq4a4u40 117 10 or or CC cord-006608-mq4a4u40 117 11 vomiting vomiting NN cord-006608-mq4a4u40 117 12 , , , cord-006608-mq4a4u40 117 13 and and CC cord-006608-mq4a4u40 117 14 absence absence NN cord-006608-mq4a4u40 117 15 of of IN cord-006608-mq4a4u40 117 16 cough cough NN cord-006608-mq4a4u40 117 17 , , , cord-006608-mq4a4u40 117 18 in in IN cord-006608-mq4a4u40 117 19 association association NN cord-006608-mq4a4u40 117 20 with with IN cord-006608-mq4a4u40 117 21 thrombocytopenia thrombocytopenia NNP cord-006608-mq4a4u40 117 22 , , , cord-006608-mq4a4u40 117 23 hemoconcentration hemoconcentration NN cord-006608-mq4a4u40 117 24 , , , cord-006608-mq4a4u40 117 25 and and CC cord-006608-mq4a4u40 117 26 acidosis acidosis NN cord-006608-mq4a4u40 117 27 , , , cord-006608-mq4a4u40 117 28 identified identify VBD cord-006608-mq4a4u40 117 29 all all DT cord-006608-mq4a4u40 117 30 patients patient NNS cord-006608-mq4a4u40 117 31 with with IN cord-006608-mq4a4u40 117 32 HPS hps NN cord-006608-mq4a4u40 117 33 and and CC cord-006608-mq4a4u40 117 34 excluded exclude VBD cord-006608-mq4a4u40 117 35 HPS hps NN cord-006608-mq4a4u40 117 36 in in IN cord-006608-mq4a4u40 117 37 at at RB cord-006608-mq4a4u40 117 38 least least RBS cord-006608-mq4a4u40 117 39 80 80 CD cord-006608-mq4a4u40 117 40 % % NN cord-006608-mq4a4u40 117 41 of of IN cord-006608-mq4a4u40 117 42 patients patient NNS cord-006608-mq4a4u40 117 43 with with IN cord-006608-mq4a4u40 117 44 unexplained unexplained JJ cord-006608-mq4a4u40 117 45 ARDS ARDS NNP cord-006608-mq4a4u40 117 46 . . . cord-006608-mq4a4u40 118 1 The the DT cord-006608-mq4a4u40 118 2 convalescent convalescent JJ cord-006608-mq4a4u40 118 3 phase phase NN cord-006608-mq4a4u40 118 4 of of IN cord-006608-mq4a4u40 118 5 HPS HPS NNP cord-006608-mq4a4u40 118 6 is be VBZ cord-006608-mq4a4u40 118 7 marked mark VBN cord-006608-mq4a4u40 118 8 by by IN cord-006608-mq4a4u40 118 9 diuresis diuresis NN cord-006608-mq4a4u40 118 10 , , , cord-006608-mq4a4u40 118 11 with with IN cord-006608-mq4a4u40 118 12 improvement improvement NN cord-006608-mq4a4u40 118 13 in in IN cord-006608-mq4a4u40 118 14 oxygenation oxygenation NN cord-006608-mq4a4u40 118 15 and and CC cord-006608-mq4a4u40 118 16 decrease decrease NN cord-006608-mq4a4u40 118 17 in in IN cord-006608-mq4a4u40 118 18 hematocrit hematocrit NN cord-006608-mq4a4u40 118 19 . . . cord-006608-mq4a4u40 119 1 Complete complete JJ cord-006608-mq4a4u40 119 2 recovery recovery NN cord-006608-mq4a4u40 119 3 can can MD cord-006608-mq4a4u40 119 4 be be VB cord-006608-mq4a4u40 119 5 rapid rapid JJ cord-006608-mq4a4u40 119 6 , , , cord-006608-mq4a4u40 119 7 even even RB cord-006608-mq4a4u40 119 8 in in IN cord-006608-mq4a4u40 119 9 patients patient NNS cord-006608-mq4a4u40 119 10 on on IN cord-006608-mq4a4u40 119 11 maximum maximum JJ cord-006608-mq4a4u40 119 12 ventilatory ventilatory NN cord-006608-mq4a4u40 119 13 and and CC cord-006608-mq4a4u40 119 14 inotropic inotropic JJ cord-006608-mq4a4u40 119 15 support support NN cord-006608-mq4a4u40 119 16 . . . cord-006608-mq4a4u40 120 1 Cognitive cognitive JJ cord-006608-mq4a4u40 120 2 impairments impairment NNS cord-006608-mq4a4u40 120 3 , , , cord-006608-mq4a4u40 120 4 especially especially RB cord-006608-mq4a4u40 120 5 involving involve VBG cord-006608-mq4a4u40 120 6 memory memory NN cord-006608-mq4a4u40 120 7 , , , cord-006608-mq4a4u40 120 8 have have VBP cord-006608-mq4a4u40 120 9 been be VBN cord-006608-mq4a4u40 120 10 described describe VBN cord-006608-mq4a4u40 120 11 in in IN cord-006608-mq4a4u40 120 12 two two CD cord-006608-mq4a4u40 120 13 HPS HPS NNP cord-006608-mq4a4u40 120 14 survivors survivor NNS cord-006608-mq4a4u40 120 15 1 1 CD cord-006608-mq4a4u40 120 16 year year NN cord-006608-mq4a4u40 120 17 after after IN cord-006608-mq4a4u40 120 18 recovery recovery NN cord-006608-mq4a4u40 120 19 [ [ -LRB- cord-006608-mq4a4u40 120 20 29 29 CD cord-006608-mq4a4u40 120 21 ] ] -RRB- cord-006608-mq4a4u40 120 22 . . . cord-006608-mq4a4u40 121 1 It -PRON- PRP cord-006608-mq4a4u40 121 2 is be VBZ cord-006608-mq4a4u40 121 3 unclear unclear JJ cord-006608-mq4a4u40 121 4 , , , cord-006608-mq4a4u40 121 5 however however RB cord-006608-mq4a4u40 121 6 , , , cord-006608-mq4a4u40 121 7 whether whether IN cord-006608-mq4a4u40 121 8 this this DT cord-006608-mq4a4u40 121 9 is be VBZ cord-006608-mq4a4u40 121 10 a a DT cord-006608-mq4a4u40 121 11 consequence consequence NN cord-006608-mq4a4u40 121 12 of of IN cord-006608-mq4a4u40 121 13 anoxic anoxic JJ cord-006608-mq4a4u40 121 14 brain brain NN cord-006608-mq4a4u40 121 15 damage damage NN cord-006608-mq4a4u40 121 16 or or CC cord-006608-mq4a4u40 121 17 viral viral RB cord-006608-mq4a4u40 121 18 - - HYPH cord-006608-mq4a4u40 121 19 induced induce VBN cord-006608-mq4a4u40 121 20 brain brain NN cord-006608-mq4a4u40 121 21 injury injury NN cord-006608-mq4a4u40 121 22 . . . cord-006608-mq4a4u40 122 1 Terajima Terajima NNP cord-006608-mq4a4u40 122 2 et et FW cord-006608-mq4a4u40 122 3 al al NNP cord-006608-mq4a4u40 122 4 . . . cord-006608-mq4a4u40 123 1 [ [ -LRB- cord-006608-mq4a4u40 123 2 30 30 CD cord-006608-mq4a4u40 123 3 ] ] -RRB- cord-006608-mq4a4u40 123 4 used use VBD cord-006608-mq4a4u40 123 5 a a DT cord-006608-mq4a4u40 123 6 quantitative quantitative JJ cord-006608-mq4a4u40 123 7 reverse reverse NN cord-006608-mq4a4u40 123 8 transcription transcription NN cord-006608-mq4a4u40 123 9 polymerase polymerase NN cord-006608-mq4a4u40 123 10 chain chain NN cord-006608-mq4a4u40 123 11 reaction reaction NN cord-006608-mq4a4u40 123 12 assay assay NN cord-006608-mq4a4u40 123 13 for for IN cord-006608-mq4a4u40 123 14 SNV SNV NNP cord-006608-mq4a4u40 123 15 to to TO cord-006608-mq4a4u40 123 16 analyze analyze VB cord-006608-mq4a4u40 123 17 samples sample NNS cord-006608-mq4a4u40 123 18 from from IN cord-006608-mq4a4u40 123 19 26 26 CD cord-006608-mq4a4u40 123 20 patients patient NNS cord-006608-mq4a4u40 123 21 with with IN cord-006608-mq4a4u40 123 22 HPS HPS NNP cord-006608-mq4a4u40 123 23 . . . cord-006608-mq4a4u40 124 1 Twenty twenty CD cord-006608-mq4a4u40 124 2 of of IN cord-006608-mq4a4u40 124 3 the the DT cord-006608-mq4a4u40 124 4 initial initial JJ cord-006608-mq4a4u40 124 5 26 26 CD cord-006608-mq4a4u40 124 6 samples sample NNS cord-006608-mq4a4u40 124 7 were be VBD cord-006608-mq4a4u40 124 8 positive positive JJ cord-006608-mq4a4u40 124 9 for for IN cord-006608-mq4a4u40 124 10 viral viral JJ cord-006608-mq4a4u40 124 11 RNA RNA NNP cord-006608-mq4a4u40 124 12 . . . cord-006608-mq4a4u40 125 1 The the DT cord-006608-mq4a4u40 125 2 mean mean JJ cord-006608-mq4a4u40 125 3 virus virus NN cord-006608-mq4a4u40 125 4 copy copy NN cord-006608-mq4a4u40 125 5 number number NN cord-006608-mq4a4u40 125 6 in in IN cord-006608-mq4a4u40 125 7 positive positive JJ cord-006608-mq4a4u40 125 8 cases case NNS cord-006608-mq4a4u40 125 9 was be VBD cord-006608-mq4a4u40 125 10 10 10 CD cord-006608-mq4a4u40 125 11 6.1±1.4 6.1±1.4 CD cord-006608-mq4a4u40 125 12 /mL. /mL. . cord-006608-mq4a4u40 126 1 Fatal fatal JJ cord-006608-mq4a4u40 126 2 cases case NNS cord-006608-mq4a4u40 126 3 had have VBD cord-006608-mq4a4u40 126 4 one one CD cord-006608-mq4a4u40 126 5 log log NN cord-006608-mq4a4u40 126 6 10 10 CD cord-006608-mq4a4u40 126 7 higher high JJR cord-006608-mq4a4u40 127 1 mean mean UH cord-006608-mq4a4u40 127 2 RNA RNA NNP cord-006608-mq4a4u40 127 3 copy copy NN cord-006608-mq4a4u40 127 4 number number NN cord-006608-mq4a4u40 127 5 compared compare VBN cord-006608-mq4a4u40 127 6 with with IN cord-006608-mq4a4u40 127 7 survivors survivor NNS cord-006608-mq4a4u40 127 8 . . . cord-006608-mq4a4u40 128 1 The the DT cord-006608-mq4a4u40 128 2 viral viral JJ cord-006608-mq4a4u40 128 3 RNA RNA NNP cord-006608-mq4a4u40 128 4 copy copy NN cord-006608-mq4a4u40 128 5 number number NN cord-006608-mq4a4u40 128 6 correlated correlate VBN cord-006608-mq4a4u40 128 7 with with IN cord-006608-mq4a4u40 128 8 the the DT cord-006608-mq4a4u40 128 9 peak peak NN cord-006608-mq4a4u40 128 10 hematocrit hematocrit NN cord-006608-mq4a4u40 128 11 value value NN cord-006608-mq4a4u40 128 12 and and CC cord-006608-mq4a4u40 128 13 lowest low JJS cord-006608-mq4a4u40 128 14 platelet platelet NN cord-006608-mq4a4u40 128 15 count count NN cord-006608-mq4a4u40 128 16 . . . cord-006608-mq4a4u40 129 1 Viremia Viremia NNP cord-006608-mq4a4u40 129 2 decreased decrease VBD cord-006608-mq4a4u40 129 3 promptly promptly RB cord-006608-mq4a4u40 129 4 after after IN cord-006608-mq4a4u40 129 5 resolution resolution NN cord-006608-mq4a4u40 129 6 of of IN cord-006608-mq4a4u40 129 7 fever fever NN cord-006608-mq4a4u40 129 8 in in IN cord-006608-mq4a4u40 129 9 eight eight CD cord-006608-mq4a4u40 129 10 survivors survivor NNS cord-006608-mq4a4u40 129 11 studied study VBD cord-006608-mq4a4u40 129 12 . . . cord-006608-mq4a4u40 130 1 show show VB cord-006608-mq4a4u40 130 2 some some DT cord-006608-mq4a4u40 130 3 clinical clinical JJ cord-006608-mq4a4u40 130 4 variations variation NNS cord-006608-mq4a4u40 130 5 . . . cord-006608-mq4a4u40 131 1 In in IN cord-006608-mq4a4u40 131 2 Black Black NNP cord-006608-mq4a4u40 131 3 Creek Creek NNP cord-006608-mq4a4u40 131 4 Canal Canal NNP cord-006608-mq4a4u40 131 5 , , , cord-006608-mq4a4u40 131 6 Bayou Bayou NNP cord-006608-mq4a4u40 131 7 , , , cord-006608-mq4a4u40 131 8 and and CC cord-006608-mq4a4u40 131 9 Andes Andes NNP cord-006608-mq4a4u40 131 10 viruses virus NNS cord-006608-mq4a4u40 131 11 , , , cord-006608-mq4a4u40 131 12 renal renal JJ cord-006608-mq4a4u40 131 13 insufficiency insufficiency NN cord-006608-mq4a4u40 131 14 and and CC cord-006608-mq4a4u40 131 15 elevated elevated JJ cord-006608-mq4a4u40 131 16 creatinine creatinine NN cord-006608-mq4a4u40 131 17 kinase kinase NN cord-006608-mq4a4u40 131 18 levels level NNS cord-006608-mq4a4u40 131 19 were be VBD cord-006608-mq4a4u40 131 20 more more RBR cord-006608-mq4a4u40 131 21 frequent frequent JJ cord-006608-mq4a4u40 131 22 [ [ -LRB- cord-006608-mq4a4u40 131 23 31•• 31•• CD cord-006608-mq4a4u40 131 24 ] ] -RRB- cord-006608-mq4a4u40 131 25 . . . cord-006608-mq4a4u40 132 1 In in IN cord-006608-mq4a4u40 132 2 Andes Andes NNP cord-006608-mq4a4u40 132 3 virus virus NN cord-006608-mq4a4u40 132 4 infection infection NN cord-006608-mq4a4u40 132 5 , , , cord-006608-mq4a4u40 132 6 bleeding bleed VBG cord-006608-mq4a4u40 132 7 manifestations manifestation NNS cord-006608-mq4a4u40 132 8 and and CC cord-006608-mq4a4u40 132 9 petechiae petechia NNS cord-006608-mq4a4u40 132 10 were be VBD cord-006608-mq4a4u40 132 11 also also RB cord-006608-mq4a4u40 132 12 reported report VBN cord-006608-mq4a4u40 132 13 [ [ -LRB- cord-006608-mq4a4u40 132 14 23 23 CD cord-006608-mq4a4u40 132 15 ] ] -RRB- cord-006608-mq4a4u40 132 16 . . . cord-006608-mq4a4u40 133 1 Cases case NNS cord-006608-mq4a4u40 133 2 of of IN cord-006608-mq4a4u40 133 3 acute acute JJ cord-006608-mq4a4u40 133 4 , , , cord-006608-mq4a4u40 133 5 seropositive seropositive JJ cord-006608-mq4a4u40 133 6 SNV SNV NNP cord-006608-mq4a4u40 133 7 infection infection NN cord-006608-mq4a4u40 133 8 that that WDT cord-006608-mq4a4u40 133 9 do do VBP cord-006608-mq4a4u40 133 10 not not RB cord-006608-mq4a4u40 133 11 fit fit VB cord-006608-mq4a4u40 133 12 diagnostic diagnostic JJ cord-006608-mq4a4u40 133 13 criteria criterion NNS cord-006608-mq4a4u40 133 14 for for IN cord-006608-mq4a4u40 133 15 HPS HPS NNP cord-006608-mq4a4u40 133 16 have have VBP cord-006608-mq4a4u40 133 17 been be VBN cord-006608-mq4a4u40 133 18 reported report VBN cord-006608-mq4a4u40 133 19 [ [ -LRB- cord-006608-mq4a4u40 133 20 25• 25• CD cord-006608-mq4a4u40 133 21 ] ] -RRB- cord-006608-mq4a4u40 133 22 . . . cord-006608-mq4a4u40 134 1 These these DT cord-006608-mq4a4u40 134 2 patients patient NNS cord-006608-mq4a4u40 134 3 presented present VBN cord-006608-mq4a4u40 134 4 with with IN cord-006608-mq4a4u40 134 5 classic classic JJ cord-006608-mq4a4u40 134 6 prodromal prodromal JJ cord-006608-mq4a4u40 134 7 symptoms symptom NNS cord-006608-mq4a4u40 134 8 but but CC cord-006608-mq4a4u40 134 9 did do VBD cord-006608-mq4a4u40 134 10 not not RB cord-006608-mq4a4u40 134 11 progress progress VB cord-006608-mq4a4u40 134 12 to to IN cord-006608-mq4a4u40 134 13 severe severe JJ cord-006608-mq4a4u40 134 14 pulmonary pulmonary JJ cord-006608-mq4a4u40 134 15 involvement involvement NN cord-006608-mq4a4u40 134 16 . . . cord-006608-mq4a4u40 135 1 Several several JJ cord-006608-mq4a4u40 135 2 of of IN cord-006608-mq4a4u40 135 3 the the DT cord-006608-mq4a4u40 135 4 laboratory laboratory NN cord-006608-mq4a4u40 135 5 findings finding NNS cord-006608-mq4a4u40 135 6 associated associate VBN cord-006608-mq4a4u40 135 7 with with IN cord-006608-mq4a4u40 135 8 HPS HPS NNP cord-006608-mq4a4u40 135 9 , , , cord-006608-mq4a4u40 135 10 including include VBG cord-006608-mq4a4u40 135 11 thrombocytopenia thrombocytopenia NN cord-006608-mq4a4u40 135 12 , , , cord-006608-mq4a4u40 135 13 atypical atypical JJ cord-006608-mq4a4u40 135 14 lymphocytosis lymphocytosis NN cord-006608-mq4a4u40 135 15 , , , cord-006608-mq4a4u40 135 16 and and CC cord-006608-mq4a4u40 135 17 elevated elevated JJ cord-006608-mq4a4u40 135 18 aminotransferase aminotransferase NN cord-006608-mq4a4u40 135 19 levels level NNS cord-006608-mq4a4u40 135 20 , , , cord-006608-mq4a4u40 135 21 were be VBD cord-006608-mq4a4u40 135 22 seen see VBN cord-006608-mq4a4u40 135 23 . . . cord-006608-mq4a4u40 136 1 Possible possible JJ cord-006608-mq4a4u40 136 2 explanations explanation NNS cord-006608-mq4a4u40 136 3 for for IN cord-006608-mq4a4u40 136 4 the the DT cord-006608-mq4a4u40 136 5 milder mild JJR cord-006608-mq4a4u40 136 6 clinical clinical JJ cord-006608-mq4a4u40 136 7 illness illness NN cord-006608-mq4a4u40 136 8 include include VBP cord-006608-mq4a4u40 136 9 a a DT cord-006608-mq4a4u40 136 10 weaker weak JJR cord-006608-mq4a4u40 136 11 immune immune JJ cord-006608-mq4a4u40 136 12 response response NN cord-006608-mq4a4u40 136 13 to to IN cord-006608-mq4a4u40 136 14 the the DT cord-006608-mq4a4u40 136 15 virus virus NN cord-006608-mq4a4u40 136 16 , , , cord-006608-mq4a4u40 136 17 altered alter VBN cord-006608-mq4a4u40 136 18 receptors receptor NNS cord-006608-mq4a4u40 136 19 , , , cord-006608-mq4a4u40 136 20 and and CC cord-006608-mq4a4u40 136 21 virologic virologic JJ cord-006608-mq4a4u40 136 22 factors factor NNS cord-006608-mq4a4u40 136 23 . . . cord-006608-mq4a4u40 137 1 The the DT cord-006608-mq4a4u40 137 2 differential differential JJ cord-006608-mq4a4u40 137 3 diagnosis diagnosis NN cord-006608-mq4a4u40 137 4 of of IN cord-006608-mq4a4u40 137 5 HPS HPS NNP cord-006608-mq4a4u40 137 6 depends depend VBZ cord-006608-mq4a4u40 137 7 on on IN cord-006608-mq4a4u40 137 8 the the DT cord-006608-mq4a4u40 137 9 clinical clinical JJ cord-006608-mq4a4u40 137 10 stage stage NN cord-006608-mq4a4u40 137 11 of of IN cord-006608-mq4a4u40 137 12 infection infection NN cord-006608-mq4a4u40 137 13 . . . cord-006608-mq4a4u40 138 1 The the DT cord-006608-mq4a4u40 138 2 prodromal prodromal JJ cord-006608-mq4a4u40 138 3 phase phase NN cord-006608-mq4a4u40 138 4 is be VBZ cord-006608-mq4a4u40 138 5 indistinguishable indistinguishable JJ cord-006608-mq4a4u40 138 6 from from IN cord-006608-mq4a4u40 138 7 many many JJ cord-006608-mq4a4u40 138 8 other other JJ cord-006608-mq4a4u40 138 9 viral viral JJ cord-006608-mq4a4u40 138 10 infections infection NNS cord-006608-mq4a4u40 138 11 . . . cord-006608-mq4a4u40 139 1 Once once IN cord-006608-mq4a4u40 139 2 infection infection NN cord-006608-mq4a4u40 139 3 progresses progress VBZ cord-006608-mq4a4u40 139 4 to to IN cord-006608-mq4a4u40 139 5 the the DT cord-006608-mq4a4u40 139 6 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 139 7 stage stage NN cord-006608-mq4a4u40 139 8 , , , cord-006608-mq4a4u40 139 9 the the DT cord-006608-mq4a4u40 139 10 differential differential JJ cord-006608-mq4a4u40 139 11 diagnosis diagnosis NN cord-006608-mq4a4u40 139 12 includes include VBZ cord-006608-mq4a4u40 139 13 leptospirosis leptospirosis NN cord-006608-mq4a4u40 139 14 , , , cord-006608-mq4a4u40 139 15 legionellosis legionellosis NN cord-006608-mq4a4u40 139 16 , , , cord-006608-mq4a4u40 139 17 chlamydial chlamydial JJ cord-006608-mq4a4u40 139 18 infection infection NN cord-006608-mq4a4u40 139 19 , , , cord-006608-mq4a4u40 139 20 mycoplasma mycoplasma NN cord-006608-mq4a4u40 139 21 infection infection NN cord-006608-mq4a4u40 139 22 , , , cord-006608-mq4a4u40 139 23 meningococcemia meningococcemia NNP cord-006608-mq4a4u40 139 24 , , , cord-006608-mq4a4u40 139 25 influenza influenza NN cord-006608-mq4a4u40 139 26 , , , cord-006608-mq4a4u40 139 27 Q Q NNP cord-006608-mq4a4u40 139 28 fever fever NN cord-006608-mq4a4u40 139 29 , , , cord-006608-mq4a4u40 139 30 pneumonic pneumonic JJ cord-006608-mq4a4u40 139 31 plague plague NN cord-006608-mq4a4u40 139 32 , , , cord-006608-mq4a4u40 139 33 tularemia tularemia NN cord-006608-mq4a4u40 139 34 , , , cord-006608-mq4a4u40 139 35 and and CC cord-006608-mq4a4u40 139 36 disseminated disseminate VBN cord-006608-mq4a4u40 139 37 fungal fungal JJ cord-006608-mq4a4u40 139 38 infections infection NNS cord-006608-mq4a4u40 139 39 . . . cord-006608-mq4a4u40 140 1 The the DT cord-006608-mq4a4u40 140 2 diagnosis diagnosis NN cord-006608-mq4a4u40 140 3 of of IN cord-006608-mq4a4u40 140 4 HPS HPS NNP cord-006608-mq4a4u40 140 5 is be VBZ cord-006608-mq4a4u40 140 6 confirmed confirm VBN cord-006608-mq4a4u40 140 7 in in IN cord-006608-mq4a4u40 140 8 a a DT cord-006608-mq4a4u40 140 9 clinically clinically RB cord-006608-mq4a4u40 140 10 compatible compatible JJ cord-006608-mq4a4u40 140 11 illness illness NN cord-006608-mq4a4u40 140 12 with with IN cord-006608-mq4a4u40 140 13 serology serology NN cord-006608-mq4a4u40 140 14 or or CC cord-006608-mq4a4u40 140 15 detection detection NN cord-006608-mq4a4u40 140 16 of of IN cord-006608-mq4a4u40 140 17 hantaviral hantaviral JJ cord-006608-mq4a4u40 140 18 antigen antigen NN cord-006608-mq4a4u40 140 19 in in IN cord-006608-mq4a4u40 140 20 tissue tissue NN cord-006608-mq4a4u40 140 21 by by IN cord-006608-mq4a4u40 140 22 immunohistochemical immunohistochemical JJ cord-006608-mq4a4u40 140 23 or or CC cord-006608-mq4a4u40 140 24 polymerase polymerase NN cord-006608-mq4a4u40 140 25 chain chain NN cord-006608-mq4a4u40 140 26 reaction reaction NN cord-006608-mq4a4u40 140 27 . . . cord-006608-mq4a4u40 141 1 Hantavirus hantavirus NN cord-006608-mq4a4u40 141 2 can can MD cord-006608-mq4a4u40 141 3 be be VB cord-006608-mq4a4u40 141 4 cultured cultured JJ cord-006608-mq4a4u40 141 5 , , , cord-006608-mq4a4u40 141 6 but but CC cord-006608-mq4a4u40 141 7 this this DT cord-006608-mq4a4u40 141 8 is be VBZ cord-006608-mq4a4u40 141 9 time time NN cord-006608-mq4a4u40 141 10 consuming consume VBG cord-006608-mq4a4u40 141 11 and and CC cord-006608-mq4a4u40 141 12 requires require VBZ cord-006608-mq4a4u40 141 13 at at IN cord-006608-mq4a4u40 141 14 least least JJS cord-006608-mq4a4u40 141 15 category category NN cord-006608-mq4a4u40 141 16 III iii CD cord-006608-mq4a4u40 141 17 containment containment NN cord-006608-mq4a4u40 141 18 facilities facility NNS cord-006608-mq4a4u40 141 19 . . . cord-006608-mq4a4u40 142 1 Serology serology NN cord-006608-mq4a4u40 142 2 detects detect VBZ cord-006608-mq4a4u40 142 3 IgM IgM NNP cord-006608-mq4a4u40 142 4 and and CC cord-006608-mq4a4u40 142 5 IgG IgG NNP cord-006608-mq4a4u40 142 6 antibodies antibody NNS cord-006608-mq4a4u40 142 7 by by IN cord-006608-mq4a4u40 142 8 enzyme enzyme NN cord-006608-mq4a4u40 142 9 - - HYPH cord-006608-mq4a4u40 142 10 linked link VBN cord-006608-mq4a4u40 142 11 immunosorbent immunosorbent JJ cord-006608-mq4a4u40 142 12 assay assay NN cord-006608-mq4a4u40 142 13 , , , cord-006608-mq4a4u40 142 14 using use VBG cord-006608-mq4a4u40 142 15 recombinant recombinant JJ cord-006608-mq4a4u40 142 16 nucleocapsid nucleocapsid NN cord-006608-mq4a4u40 142 17 proteins protein NNS cord-006608-mq4a4u40 142 18 of of IN cord-006608-mq4a4u40 142 19 different different JJ cord-006608-mq4a4u40 142 20 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 142 21 . . . cord-006608-mq4a4u40 143 1 Serum serum NN cord-006608-mq4a4u40 143 2 samples sample NNS cord-006608-mq4a4u40 143 3 from from IN cord-006608-mq4a4u40 143 4 acute acute JJ cord-006608-mq4a4u40 143 5 and and CC cord-006608-mq4a4u40 143 6 convalescent convalescent JJ cord-006608-mq4a4u40 143 7 phases phase NNS cord-006608-mq4a4u40 143 8 in in IN cord-006608-mq4a4u40 143 9 patients patient NNS cord-006608-mq4a4u40 143 10 [ [ -LRB- cord-006608-mq4a4u40 143 11 33 33 CD cord-006608-mq4a4u40 143 12 ] ] -RRB- cord-006608-mq4a4u40 143 13 . . . cord-006608-mq4a4u40 144 1 Among among IN cord-006608-mq4a4u40 144 2 SNV SNV NNP cord-006608-mq4a4u40 144 3 - - HYPH cord-006608-mq4a4u40 144 4 specific specific JJ cord-006608-mq4a4u40 144 5 IgG igg NN cord-006608-mq4a4u40 144 6 antibodies antibody NNS cord-006608-mq4a4u40 144 7 reported report VBD cord-006608-mq4a4u40 144 8 in in IN cord-006608-mq4a4u40 144 9 one one CD cord-006608-mq4a4u40 144 10 study study NN cord-006608-mq4a4u40 144 11 [ [ -LRB- cord-006608-mq4a4u40 144 12 34 34 CD cord-006608-mq4a4u40 144 13 ] ] -RRB- cord-006608-mq4a4u40 144 14 , , , cord-006608-mq4a4u40 144 15 the the DT cord-006608-mq4a4u40 144 16 most most RBS cord-006608-mq4a4u40 144 17 prevalent prevalent JJ cord-006608-mq4a4u40 144 18 were be VBD cord-006608-mq4a4u40 144 19 IgG3 igg3 NN cord-006608-mq4a4u40 144 20 ( ( -LRB- cord-006608-mq4a4u40 144 21 97 97 CD cord-006608-mq4a4u40 144 22 % % NN cord-006608-mq4a4u40 144 23 ) ) -RRB- cord-006608-mq4a4u40 144 24 , , , cord-006608-mq4a4u40 144 25 IgG1 igg1 FW cord-006608-mq4a4u40 144 26 ( ( -LRB- cord-006608-mq4a4u40 144 27 70 70 CD cord-006608-mq4a4u40 144 28 % % NN cord-006608-mq4a4u40 144 29 ) ) -RRB- cord-006608-mq4a4u40 144 30 , , , cord-006608-mq4a4u40 144 31 IgG2 igg2 NN cord-006608-mq4a4u40 144 32 ( ( -LRB- cord-006608-mq4a4u40 144 33 30 30 CD cord-006608-mq4a4u40 144 34 % % NN cord-006608-mq4a4u40 144 35 ) ) -RRB- cord-006608-mq4a4u40 144 36 , , , cord-006608-mq4a4u40 144 37 and and CC cord-006608-mq4a4u40 144 38 IgG4 igg4 NN cord-006608-mq4a4u40 144 39 ( ( -LRB- cord-006608-mq4a4u40 144 40 3 3 CD cord-006608-mq4a4u40 144 41 % % NN cord-006608-mq4a4u40 144 42 ) ) -RRB- cord-006608-mq4a4u40 144 43 . . . cord-006608-mq4a4u40 145 1 It -PRON- PRP cord-006608-mq4a4u40 145 2 is be VBZ cord-006608-mq4a4u40 145 3 postulated postulate VBN cord-006608-mq4a4u40 145 4 that that IN cord-006608-mq4a4u40 145 5 the the DT cord-006608-mq4a4u40 145 6 cytokines cytokine NNS cord-006608-mq4a4u40 145 7 produced produce VBN cord-006608-mq4a4u40 145 8 in in IN cord-006608-mq4a4u40 145 9 SNV SNV NNP cord-006608-mq4a4u40 145 10 infection infection NN cord-006608-mq4a4u40 145 11 may may MD cord-006608-mq4a4u40 145 12 preferentially preferentially RB cord-006608-mq4a4u40 145 13 stimulate stimulate VB cord-006608-mq4a4u40 145 14 production production NN cord-006608-mq4a4u40 145 15 of of IN cord-006608-mq4a4u40 145 16 IgG3 igg3 NN cord-006608-mq4a4u40 145 17 subclass subclass NN cord-006608-mq4a4u40 145 18 antibody antibody NN cord-006608-mq4a4u40 145 19 . . . cord-006608-mq4a4u40 146 1 In in IN cord-006608-mq4a4u40 146 2 this this DT cord-006608-mq4a4u40 146 3 study study NN cord-006608-mq4a4u40 146 4 , , , cord-006608-mq4a4u40 146 5 antibody antibody NN cord-006608-mq4a4u40 146 6 titers titer NNS cord-006608-mq4a4u40 146 7 were be VBD cord-006608-mq4a4u40 146 8 similar similar JJ cord-006608-mq4a4u40 146 9 in in IN cord-006608-mq4a4u40 146 10 patients patient NNS cord-006608-mq4a4u40 146 11 who who WP cord-006608-mq4a4u40 146 12 died die VBD cord-006608-mq4a4u40 146 13 and and CC cord-006608-mq4a4u40 146 14 those those DT cord-006608-mq4a4u40 146 15 who who WP cord-006608-mq4a4u40 146 16 survived survive VBD cord-006608-mq4a4u40 146 17 . . . cord-006608-mq4a4u40 147 1 IgG IgG NNP cord-006608-mq4a4u40 147 2 antibody antibody NN cord-006608-mq4a4u40 147 3 persists persist VBZ cord-006608-mq4a4u40 147 4 for for IN cord-006608-mq4a4u40 147 5 years year NNS cord-006608-mq4a4u40 147 6 . . . cord-006608-mq4a4u40 148 1 Reinfection Reinfection NNP cord-006608-mq4a4u40 148 2 with with IN cord-006608-mq4a4u40 148 3 homologous homologous JJ cord-006608-mq4a4u40 148 4 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 148 5 is be VBZ cord-006608-mq4a4u40 148 6 not not RB cord-006608-mq4a4u40 148 7 known know VBN cord-006608-mq4a4u40 148 8 to to TO cord-006608-mq4a4u40 148 9 occur occur VB cord-006608-mq4a4u40 148 10 in in IN cord-006608-mq4a4u40 148 11 humans human NNS cord-006608-mq4a4u40 148 12 . . . cord-006608-mq4a4u40 149 1 The the DT cord-006608-mq4a4u40 149 2 major major JJ cord-006608-mq4a4u40 149 3 difficulty difficulty NN cord-006608-mq4a4u40 149 4 with with IN cord-006608-mq4a4u40 149 5 serologic serologic JJ cord-006608-mq4a4u40 149 6 diagnosis diagnosis NN cord-006608-mq4a4u40 149 7 is be VBZ cord-006608-mq4a4u40 149 8 the the DT cord-006608-mq4a4u40 149 9 delay delay NN cord-006608-mq4a4u40 149 10 in in IN cord-006608-mq4a4u40 149 11 obtaining obtain VBG cord-006608-mq4a4u40 149 12 results result NNS cord-006608-mq4a4u40 149 13 . . . cord-006608-mq4a4u40 150 1 A a DT cord-006608-mq4a4u40 150 2 rapid rapid JJ cord-006608-mq4a4u40 150 3 antibody antibody NN cord-006608-mq4a4u40 150 4 test test NN cord-006608-mq4a4u40 150 5 for for IN cord-006608-mq4a4u40 150 6 SNV SNV NNP cord-006608-mq4a4u40 150 7 in in IN cord-006608-mq4a4u40 150 8 the the DT cord-006608-mq4a4u40 150 9 form form NN cord-006608-mq4a4u40 150 10 of of IN cord-006608-mq4a4u40 150 11 a a DT cord-006608-mq4a4u40 150 12 strip strip NN cord-006608-mq4a4u40 150 13 immunoblot immunoblot NNP cord-006608-mq4a4u40 150 14 assay assay NN cord-006608-mq4a4u40 150 15 has have VBZ cord-006608-mq4a4u40 150 16 been be VBN cord-006608-mq4a4u40 150 17 developed develop VBN cord-006608-mq4a4u40 150 18 ; ; : cord-006608-mq4a4u40 150 19 this this DT cord-006608-mq4a4u40 150 20 test test NN cord-006608-mq4a4u40 150 21 takes take VBZ cord-006608-mq4a4u40 150 22 about about RB cord-006608-mq4a4u40 150 23 5 5 CD cord-006608-mq4a4u40 150 24 hours hour NNS cord-006608-mq4a4u40 150 25 to to TO cord-006608-mq4a4u40 150 26 complete complete VB cord-006608-mq4a4u40 150 27 . . . cord-006608-mq4a4u40 151 1 The the DT cord-006608-mq4a4u40 151 2 assay assay NN cord-006608-mq4a4u40 151 3 incorporates incorporate VBZ cord-006608-mq4a4u40 151 4 antigens antigen NNS cord-006608-mq4a4u40 151 5 derived derive VBN cord-006608-mq4a4u40 151 6 from from IN cord-006608-mq4a4u40 151 7 synthetic synthetic JJ cord-006608-mq4a4u40 151 8 peptide peptide NN cord-006608-mq4a4u40 151 9 and and CC cord-006608-mq4a4u40 151 10 recombinantexpressed recombinantexpressed JJ cord-006608-mq4a4u40 151 11 forms form NNS cord-006608-mq4a4u40 151 12 of of IN cord-006608-mq4a4u40 151 13 SNV SNV NNP cord-006608-mq4a4u40 151 14 glycoprotein glycoprotein NN cord-006608-mq4a4u40 151 15 and and CC cord-006608-mq4a4u40 151 16 nucleocapsid nucleocapsid NN cord-006608-mq4a4u40 151 17 protein protein NN cord-006608-mq4a4u40 151 18 , , , cord-006608-mq4a4u40 151 19 as as RB cord-006608-mq4a4u40 151 20 well well RB cord-006608-mq4a4u40 151 21 as as IN cord-006608-mq4a4u40 151 22 recombinant recombinant NN cord-006608-mq4a4u40 151 23 - - HYPH cord-006608-mq4a4u40 151 24 expressed express VBN cord-006608-mq4a4u40 151 25 Seoul Seoul NNP cord-006608-mq4a4u40 151 26 virus virus NN cord-006608-mq4a4u40 151 27 nucleocapsid nucleocapsid NN cord-006608-mq4a4u40 151 28 protein protein NN cord-006608-mq4a4u40 151 29 . . . cord-006608-mq4a4u40 152 1 In in IN cord-006608-mq4a4u40 152 2 studies study NNS cord-006608-mq4a4u40 152 3 , , , cord-006608-mq4a4u40 152 4 this this DT cord-006608-mq4a4u40 152 5 assay assay NN cord-006608-mq4a4u40 152 6 identified identify VBD cord-006608-mq4a4u40 152 7 all all DT cord-006608-mq4a4u40 152 8 patients patient NNS cord-006608-mq4a4u40 152 9 with with IN cord-006608-mq4a4u40 152 10 acute acute JJ cord-006608-mq4a4u40 152 11 SNV SNV NNP cord-006608-mq4a4u40 152 12 infection infection NN cord-006608-mq4a4u40 152 13 from from IN cord-006608-mq4a4u40 152 14 the the DT cord-006608-mq4a4u40 152 15 earliest early JJS cord-006608-mq4a4u40 152 16 clinical clinical JJ cord-006608-mq4a4u40 152 17 samples sample NNS cord-006608-mq4a4u40 152 18 with with IN cord-006608-mq4a4u40 152 19 no no DT cord-006608-mq4a4u40 152 20 false false JJ cord-006608-mq4a4u40 152 21 - - HYPH cord-006608-mq4a4u40 152 22 positive positive JJ cord-006608-mq4a4u40 152 23 results result NNS cord-006608-mq4a4u40 152 24 in in IN cord-006608-mq4a4u40 152 25 controls control NNS cord-006608-mq4a4u40 152 26 [ [ -LRB- cord-006608-mq4a4u40 152 27 33 33 CD cord-006608-mq4a4u40 152 28 ] ] -RRB- cord-006608-mq4a4u40 152 29 . . . cord-006608-mq4a4u40 153 1 Gross gross JJ cord-006608-mq4a4u40 153 2 pathologic pathologic JJ cord-006608-mq4a4u40 153 3 examination examination NN cord-006608-mq4a4u40 153 4 of of IN cord-006608-mq4a4u40 153 5 the the DT cord-006608-mq4a4u40 153 6 lungs lung NNS cord-006608-mq4a4u40 153 7 from from IN cord-006608-mq4a4u40 153 8 patients patient NNS cord-006608-mq4a4u40 153 9 with with IN cord-006608-mq4a4u40 153 10 HPS hps NN cord-006608-mq4a4u40 153 11 shows show VBZ cord-006608-mq4a4u40 153 12 edema edema NN cord-006608-mq4a4u40 153 13 and and CC cord-006608-mq4a4u40 153 14 large large JJ cord-006608-mq4a4u40 153 15 serous serous JJ cord-006608-mq4a4u40 153 16 pleural pleural JJ cord-006608-mq4a4u40 153 17 effusions effusion NNS cord-006608-mq4a4u40 153 18 . . . cord-006608-mq4a4u40 154 1 Microscopic microscopic JJ cord-006608-mq4a4u40 154 2 examination examination NN cord-006608-mq4a4u40 154 3 reveals reveal VBZ cord-006608-mq4a4u40 154 4 intra intra JJ cord-006608-mq4a4u40 154 5 - - JJ cord-006608-mq4a4u40 154 6 alveolar alveolar JJ cord-006608-mq4a4u40 154 7 edema edema NN cord-006608-mq4a4u40 154 8 and and CC cord-006608-mq4a4u40 154 9 interstitial interstitial JJ cord-006608-mq4a4u40 154 10 lymphocytic lymphocytic NN cord-006608-mq4a4u40 154 11 infiltrates infiltrate VBZ cord-006608-mq4a4u40 154 12 . . . cord-006608-mq4a4u40 155 1 Minimal minimal JJ cord-006608-mq4a4u40 155 2 hyaline hyaline JJ cord-006608-mq4a4u40 155 3 membrane membrane NN cord-006608-mq4a4u40 155 4 formation formation NN cord-006608-mq4a4u40 155 5 and and CC cord-006608-mq4a4u40 155 6 rare rare JJ cord-006608-mq4a4u40 155 7 neutrophils neutrophil NNS cord-006608-mq4a4u40 155 8 help help VBP cord-006608-mq4a4u40 155 9 distinguish distinguish VB cord-006608-mq4a4u40 155 10 HPS HPS NNP cord-006608-mq4a4u40 155 11 from from IN cord-006608-mq4a4u40 155 12 ARDS ARDS NNP cord-006608-mq4a4u40 155 13 . . . cord-006608-mq4a4u40 156 1 A a DT cord-006608-mq4a4u40 156 2 viral viral JJ cord-006608-mq4a4u40 156 3 cytopathic cytopathic JJ cord-006608-mq4a4u40 156 4 effect effect NN cord-006608-mq4a4u40 156 5 is be VBZ cord-006608-mq4a4u40 156 6 notably notably RB cord-006608-mq4a4u40 156 7 absent absent JJ cord-006608-mq4a4u40 156 8 [ [ -LRB- cord-006608-mq4a4u40 156 9 17 17 CD cord-006608-mq4a4u40 156 10 ] ] -RRB- cord-006608-mq4a4u40 156 11 . . . cord-006608-mq4a4u40 157 1 Immunohistochemical immunohistochemical JJ cord-006608-mq4a4u40 157 2 analysis analysis NN cord-006608-mq4a4u40 157 3 has have VBZ cord-006608-mq4a4u40 157 4 demonstrated demonstrate VBN cord-006608-mq4a4u40 157 5 viral viral JJ cord-006608-mq4a4u40 157 6 antigen antigen NN cord-006608-mq4a4u40 157 7 distributed distribute VBN cord-006608-mq4a4u40 157 8 in in IN cord-006608-mq4a4u40 157 9 the the DT cord-006608-mq4a4u40 157 10 capillary capillary JJ cord-006608-mq4a4u40 157 11 endothelium endothelium NN cord-006608-mq4a4u40 157 12 of of IN cord-006608-mq4a4u40 157 13 multiple multiple JJ cord-006608-mq4a4u40 157 14 organs organ NNS cord-006608-mq4a4u40 157 15 , , , cord-006608-mq4a4u40 157 16 most most RBS cord-006608-mq4a4u40 157 17 markedly markedly RB cord-006608-mq4a4u40 157 18 in in IN cord-006608-mq4a4u40 157 19 the the DT cord-006608-mq4a4u40 157 20 pulmonary pulmonary JJ cord-006608-mq4a4u40 157 21 vasculature vasculature NN cord-006608-mq4a4u40 157 22 [ [ -LRB- cord-006608-mq4a4u40 157 23 35 35 CD cord-006608-mq4a4u40 157 24 ] ] -RRB- cord-006608-mq4a4u40 157 25 . . . cord-006608-mq4a4u40 158 1 The the DT cord-006608-mq4a4u40 158 2 pulmonary pulmonary JJ cord-006608-mq4a4u40 158 3 endothelial endothelial JJ cord-006608-mq4a4u40 158 4 cells cell NNS cord-006608-mq4a4u40 158 5 and and CC cord-006608-mq4a4u40 158 6 pneumocytes pneumocyte NNS cord-006608-mq4a4u40 158 7 show show VBP cord-006608-mq4a4u40 158 8 no no DT cord-006608-mq4a4u40 158 9 evidence evidence NN cord-006608-mq4a4u40 158 10 of of IN cord-006608-mq4a4u40 158 11 direct direct JJ cord-006608-mq4a4u40 158 12 viral viral JJ cord-006608-mq4a4u40 158 13 injury injury NN cord-006608-mq4a4u40 158 14 , , , cord-006608-mq4a4u40 158 15 which which WDT cord-006608-mq4a4u40 158 16 may may MD cord-006608-mq4a4u40 158 17 account account VB cord-006608-mq4a4u40 158 18 for for IN cord-006608-mq4a4u40 158 19 the the DT cord-006608-mq4a4u40 158 20 rapid rapid JJ cord-006608-mq4a4u40 158 21 recovery recovery NN cord-006608-mq4a4u40 158 22 observed observe VBN cord-006608-mq4a4u40 158 23 in in IN cord-006608-mq4a4u40 158 24 survivors survivor NNS cord-006608-mq4a4u40 158 25 . . . cord-006608-mq4a4u40 159 1 The the DT cord-006608-mq4a4u40 159 2 increased increase VBN cord-006608-mq4a4u40 159 3 pulmonary pulmonary JJ cord-006608-mq4a4u40 159 4 capillary capillary JJ cord-006608-mq4a4u40 159 5 permeability permeability NN cord-006608-mq4a4u40 159 6 with with IN cord-006608-mq4a4u40 159 7 structurally structurally RB cord-006608-mq4a4u40 159 8 intact intact JJ cord-006608-mq4a4u40 159 9 cells cell NNS cord-006608-mq4a4u40 159 10 and and CC cord-006608-mq4a4u40 159 11 interstitial interstitial JJ cord-006608-mq4a4u40 159 12 lymphocytic lymphocytic NN cord-006608-mq4a4u40 159 13 infiltrates infiltrate VBZ cord-006608-mq4a4u40 159 14 suggests suggest VBZ cord-006608-mq4a4u40 159 15 a a DT cord-006608-mq4a4u40 159 16 pathogenic pathogenic JJ cord-006608-mq4a4u40 159 17 role role NN cord-006608-mq4a4u40 159 18 for for IN cord-006608-mq4a4u40 159 19 the the DT cord-006608-mq4a4u40 159 20 immune immune JJ cord-006608-mq4a4u40 159 21 system system NN cord-006608-mq4a4u40 159 22 . . . cord-006608-mq4a4u40 160 1 Activated activate VBN cord-006608-mq4a4u40 160 2 T t NN cord-006608-mq4a4u40 160 3 cells cell NNS cord-006608-mq4a4u40 160 4 , , , cord-006608-mq4a4u40 160 5 primarily primarily RB cord-006608-mq4a4u40 160 6 CD8 CD8 NNP cord-006608-mq4a4u40 160 7 + + CC cord-006608-mq4a4u40 160 8 cells cell NNS cord-006608-mq4a4u40 160 9 , , , cord-006608-mq4a4u40 160 10 are be VBP cord-006608-mq4a4u40 160 11 prominent prominent JJ cord-006608-mq4a4u40 160 12 in in IN cord-006608-mq4a4u40 160 13 lung lung NN cord-006608-mq4a4u40 160 14 lesions lesion NNS cord-006608-mq4a4u40 160 15 and and CC cord-006608-mq4a4u40 160 16 blood blood NN cord-006608-mq4a4u40 160 17 . . . cord-006608-mq4a4u40 161 1 It -PRON- PRP cord-006608-mq4a4u40 161 2 is be VBZ cord-006608-mq4a4u40 161 3 postulated postulate VBN cord-006608-mq4a4u40 161 4 that that IN cord-006608-mq4a4u40 161 5 T t NN cord-006608-mq4a4u40 161 6 cells cell NNS cord-006608-mq4a4u40 161 7 recognize recognize VBP cord-006608-mq4a4u40 161 8 and and CC cord-006608-mq4a4u40 161 9 act act VB cord-006608-mq4a4u40 161 10 on on IN cord-006608-mq4a4u40 161 11 the the DT cord-006608-mq4a4u40 161 12 heavily heavily RB cord-006608-mq4a4u40 161 13 infected infected JJ cord-006608-mq4a4u40 161 14 pulmonary pulmonary JJ cord-006608-mq4a4u40 161 15 cells cell NNS cord-006608-mq4a4u40 161 16 , , , cord-006608-mq4a4u40 161 17 resulting result VBG cord-006608-mq4a4u40 161 18 in in IN cord-006608-mq4a4u40 161 19 the the DT cord-006608-mq4a4u40 161 20 secretion secretion NN cord-006608-mq4a4u40 161 21 of of IN cord-006608-mq4a4u40 161 22 inflammatory inflammatory JJ cord-006608-mq4a4u40 161 23 mediators mediator NNS cord-006608-mq4a4u40 161 24 such such JJ cord-006608-mq4a4u40 161 25 as as IN cord-006608-mq4a4u40 161 26 interferon interferon NN cord-006608-mq4a4u40 161 27 - - HYPH cord-006608-mq4a4u40 161 28 γ γ NN cord-006608-mq4a4u40 161 29 and and CC cord-006608-mq4a4u40 161 30 tumor tumor NN cord-006608-mq4a4u40 161 31 necrosis necrosis NN cord-006608-mq4a4u40 161 32 factor factor NN cord-006608-mq4a4u40 161 33 . . . cord-006608-mq4a4u40 162 1 These these DT cord-006608-mq4a4u40 162 2 lymphokines lymphokine NNS cord-006608-mq4a4u40 162 3 may may MD cord-006608-mq4a4u40 162 4 mediate mediate VB cord-006608-mq4a4u40 162 5 the the DT cord-006608-mq4a4u40 162 6 reversible reversible JJ cord-006608-mq4a4u40 162 7 increase increase NN cord-006608-mq4a4u40 162 8 in in IN cord-006608-mq4a4u40 162 9 vascular vascular JJ cord-006608-mq4a4u40 162 10 permeability permeability NN cord-006608-mq4a4u40 162 11 resulting result VBG cord-006608-mq4a4u40 162 12 in in IN cord-006608-mq4a4u40 162 13 pulmonary pulmonary JJ cord-006608-mq4a4u40 162 14 edema edema NN cord-006608-mq4a4u40 162 15 [ [ -LRB- cord-006608-mq4a4u40 162 16 31•• 31•• CD cord-006608-mq4a4u40 162 17 ] ] -RRB- cord-006608-mq4a4u40 162 18 . . . cord-006608-mq4a4u40 163 1 Mori Mori NNP cord-006608-mq4a4u40 163 2 et et FW cord-006608-mq4a4u40 163 3 al al NNP cord-006608-mq4a4u40 163 4 . . . cord-006608-mq4a4u40 164 1 [ [ -LRB- cord-006608-mq4a4u40 164 2 36 36 CD cord-006608-mq4a4u40 164 3 ] ] -RRB- cord-006608-mq4a4u40 164 4 demonstrated demonstrate VBN cord-006608-mq4a4u40 164 5 specific specific JJ cord-006608-mq4a4u40 164 6 localization localization NN cord-006608-mq4a4u40 164 7 of of IN cord-006608-mq4a4u40 164 8 cytokine cytokine NN cord-006608-mq4a4u40 164 9 - - HYPH cord-006608-mq4a4u40 164 10 producing produce VBG cord-006608-mq4a4u40 164 11 cells cell NNS cord-006608-mq4a4u40 164 12 in in IN cord-006608-mq4a4u40 164 13 the the DT cord-006608-mq4a4u40 164 14 lungs lung NNS cord-006608-mq4a4u40 164 15 of of IN cord-006608-mq4a4u40 164 16 patients patient NNS cord-006608-mq4a4u40 164 17 with with IN cord-006608-mq4a4u40 164 18 HPS HPS NNP cord-006608-mq4a4u40 164 19 , , , cord-006608-mq4a4u40 164 20 paralleling parallel VBG cord-006608-mq4a4u40 164 21 the the DT cord-006608-mq4a4u40 164 22 distribution distribution NN cord-006608-mq4a4u40 164 23 of of IN cord-006608-mq4a4u40 164 24 hantaviral hantaviral JJ cord-006608-mq4a4u40 164 25 antigens antigen NNS cord-006608-mq4a4u40 164 26 . . . cord-006608-mq4a4u40 165 1 Testing testing NN cord-006608-mq4a4u40 165 2 detected detect VBD cord-006608-mq4a4u40 165 3 cells cell NNS cord-006608-mq4a4u40 165 4 that that WDT cord-006608-mq4a4u40 165 5 produced produce VBD cord-006608-mq4a4u40 165 6 both both DT cord-006608-mq4a4u40 165 7 monocyte monocyte NNP cord-006608-mq4a4u40 165 8 - - HYPH cord-006608-mq4a4u40 165 9 derived derive VBN cord-006608-mq4a4u40 165 10 cytokines cytokine NNS cord-006608-mq4a4u40 165 11 ( ( -LRB- cord-006608-mq4a4u40 165 12 including include VBG cord-006608-mq4a4u40 165 13 interleukin-1α interleukin-1α NNP cord-006608-mq4a4u40 165 14 , , , cord-006608-mq4a4u40 165 15 interleukin-1β interleukin-1β NNP cord-006608-mq4a4u40 165 16 , , , cord-006608-mq4a4u40 165 17 interleukin-6 interleukin-6 NNP cord-006608-mq4a4u40 165 18 , , , cord-006608-mq4a4u40 165 19 and and CC cord-006608-mq4a4u40 165 20 tumor tumor NN cord-006608-mq4a4u40 165 21 necrosis necrosis NN cord-006608-mq4a4u40 165 22 factor factor NN cord-006608-mq4a4u40 165 23 - - HYPH cord-006608-mq4a4u40 165 24 α α NN cord-006608-mq4a4u40 165 25 ) ) -RRB- cord-006608-mq4a4u40 165 26 and and CC cord-006608-mq4a4u40 165 27 lymphocyte lymphocyte NN cord-006608-mq4a4u40 165 28 - - HYPH cord-006608-mq4a4u40 165 29 derived derive VBN cord-006608-mq4a4u40 165 30 cytokines cytokine NNS cord-006608-mq4a4u40 165 31 ( ( -LRB- cord-006608-mq4a4u40 165 32 including include VBG cord-006608-mq4a4u40 165 33 interferon interferon NN cord-006608-mq4a4u40 165 34 - - HYPH cord-006608-mq4a4u40 165 35 γ γ NN cord-006608-mq4a4u40 165 36 , , , cord-006608-mq4a4u40 165 37 interleukin-2 interleukin-2 RB cord-006608-mq4a4u40 165 38 , , , cord-006608-mq4a4u40 165 39 interleukin-4 interleukin-4 NNP cord-006608-mq4a4u40 165 40 , , , cord-006608-mq4a4u40 165 41 and and CC cord-006608-mq4a4u40 165 42 tumor tumor NN cord-006608-mq4a4u40 165 43 necrosis necrosis NN cord-006608-mq4a4u40 165 44 factor factor NN cord-006608-mq4a4u40 165 45 - - HYPH cord-006608-mq4a4u40 165 46 β β NN cord-006608-mq4a4u40 165 47 ) ) -RRB- cord-006608-mq4a4u40 165 48 . . . cord-006608-mq4a4u40 166 1 Cytokine cytokine NN cord-006608-mq4a4u40 166 2 production production NN cord-006608-mq4a4u40 166 3 by by IN cord-006608-mq4a4u40 166 4 both both CC cord-006608-mq4a4u40 166 5 activated activate VBN cord-006608-mq4a4u40 166 6 T t NN cord-006608-mq4a4u40 166 7 lymphocytes lymphocyte NNS cord-006608-mq4a4u40 166 8 and and CC cord-006608-mq4a4u40 166 9 monocytes monocyte VBZ cord-006608-mq4a4u40 166 10 probably probably RB cord-006608-mq4a4u40 166 11 contributes contribute VBZ cord-006608-mq4a4u40 166 12 to to IN cord-006608-mq4a4u40 166 13 the the DT cord-006608-mq4a4u40 166 14 pathogenesis pathogenesis NN cord-006608-mq4a4u40 166 15 of of IN cord-006608-mq4a4u40 166 16 the the DT cord-006608-mq4a4u40 166 17 capillary capillary JJ cord-006608-mq4a4u40 166 18 leak leak NN cord-006608-mq4a4u40 166 19 syndrome syndrome NN cord-006608-mq4a4u40 166 20 in in IN cord-006608-mq4a4u40 166 21 HPS HPS NNP cord-006608-mq4a4u40 166 22 and and CC cord-006608-mq4a4u40 166 23 the the DT cord-006608-mq4a4u40 166 24 renal renal JJ cord-006608-mq4a4u40 166 25 failure failure NN cord-006608-mq4a4u40 166 26 observed observe VBN cord-006608-mq4a4u40 166 27 with with IN cord-006608-mq4a4u40 166 28 HFRS HFRS NNP cord-006608-mq4a4u40 166 29 . . . cord-006608-mq4a4u40 167 1 The the DT cord-006608-mq4a4u40 167 2 cellular cellular JJ cord-006608-mq4a4u40 167 3 receptor receptor NN cord-006608-mq4a4u40 167 4 for for IN cord-006608-mq4a4u40 167 5 pathogenic pathogenic JJ cord-006608-mq4a4u40 167 6 hantaviruses hantaviruses NNPS cord-006608-mq4a4u40 167 7 has have VBZ cord-006608-mq4a4u40 167 8 recently recently RB cord-006608-mq4a4u40 167 9 been be VBN cord-006608-mq4a4u40 167 10 identified identify VBN cord-006608-mq4a4u40 167 11 as as IN cord-006608-mq4a4u40 167 12 the the DT cord-006608-mq4a4u40 167 13 β-3 β-3 NNP cord-006608-mq4a4u40 167 14 integrins integrin NNS cord-006608-mq4a4u40 167 15 [ [ -LRB- cord-006608-mq4a4u40 167 16 37• 37• CD cord-006608-mq4a4u40 167 17 ] ] -RRB- cord-006608-mq4a4u40 167 18 . . . cord-006608-mq4a4u40 168 1 Integrins integrin NNS cord-006608-mq4a4u40 168 2 help help VBP cord-006608-mq4a4u40 168 3 regulate regulate VB cord-006608-mq4a4u40 168 4 vascular vascular JJ cord-006608-mq4a4u40 168 5 permeability permeability NN cord-006608-mq4a4u40 168 6 and and CC cord-006608-mq4a4u40 168 7 platelet platelet NN cord-006608-mq4a4u40 168 8 function function NN cord-006608-mq4a4u40 168 9 . . . cord-006608-mq4a4u40 169 1 Specific specific JJ cord-006608-mq4a4u40 169 2 integrins integrin NNS cord-006608-mq4a4u40 169 3 expressed express VBN cord-006608-mq4a4u40 169 4 on on IN cord-006608-mq4a4u40 169 5 platelets platelet NNS cord-006608-mq4a4u40 169 6 and and CC cord-006608-mq4a4u40 169 7 endothelial endothelial JJ cord-006608-mq4a4u40 169 8 cells cell NNS cord-006608-mq4a4u40 169 9 permit permit VBP cord-006608-mq4a4u40 169 10 entry entry NN cord-006608-mq4a4u40 169 11 of of IN cord-006608-mq4a4u40 169 12 HPS hps NN cord-006608-mq4a4u40 169 13 - - HYPH cord-006608-mq4a4u40 169 14 associated associate VBN cord-006608-mq4a4u40 169 15 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 169 16 . . . cord-006608-mq4a4u40 170 1 The the DT cord-006608-mq4a4u40 170 2 hantavirus hantavirus NN cord-006608-mq4a4u40 170 3 - - HYPH cord-006608-mq4a4u40 170 4 integrin integrin NN cord-006608-mq4a4u40 170 5 interaction interaction NN cord-006608-mq4a4u40 170 6 , , , cord-006608-mq4a4u40 170 7 by by IN cord-006608-mq4a4u40 170 8 altering alter VBG cord-006608-mq4a4u40 170 9 normal normal JJ cord-006608-mq4a4u40 170 10 endothelial endothelial JJ cord-006608-mq4a4u40 170 11 cell cell NN cord-006608-mq4a4u40 170 12 barrier barrier NN cord-006608-mq4a4u40 170 13 functions function NNS cord-006608-mq4a4u40 170 14 , , , cord-006608-mq4a4u40 170 15 may may MD cord-006608-mq4a4u40 170 16 be be VB cord-006608-mq4a4u40 170 17 responsible responsible JJ cord-006608-mq4a4u40 170 18 for for IN cord-006608-mq4a4u40 170 19 the the DT cord-006608-mq4a4u40 170 20 abnormal abnormal JJ cord-006608-mq4a4u40 170 21 vascular vascular JJ cord-006608-mq4a4u40 170 22 permeability permeability NN cord-006608-mq4a4u40 170 23 associated associate VBN cord-006608-mq4a4u40 170 24 with with IN cord-006608-mq4a4u40 170 25 HPS HPS NNP cord-006608-mq4a4u40 170 26 . . . cord-006608-mq4a4u40 171 1 In in IN cord-006608-mq4a4u40 171 2 tissue tissue NN cord-006608-mq4a4u40 171 3 culture culture NN cord-006608-mq4a4u40 171 4 , , , cord-006608-mq4a4u40 171 5 the the DT cord-006608-mq4a4u40 171 6 entry entry NN cord-006608-mq4a4u40 171 7 of of IN cord-006608-mq4a4u40 171 8 HPS hps NN cord-006608-mq4a4u40 171 9 - - HYPH cord-006608-mq4a4u40 171 10 associated associate VBN cord-006608-mq4a4u40 171 11 hantavirus hantavirus NN cord-006608-mq4a4u40 171 12 into into IN cord-006608-mq4a4u40 171 13 cells cell NNS cord-006608-mq4a4u40 171 14 was be VBD cord-006608-mq4a4u40 171 15 partially partially RB cord-006608-mq4a4u40 171 16 blocked block VBN cord-006608-mq4a4u40 171 17 by by IN cord-006608-mq4a4u40 171 18 antibodies antibody NNS cord-006608-mq4a4u40 171 19 to to IN cord-006608-mq4a4u40 171 20 the the DT cord-006608-mq4a4u40 171 21 integrins integrin NNS cord-006608-mq4a4u40 171 22 , , , cord-006608-mq4a4u40 171 23 suggesting suggest VBG cord-006608-mq4a4u40 171 24 a a DT cord-006608-mq4a4u40 171 25 possible possible JJ cord-006608-mq4a4u40 171 26 future future JJ cord-006608-mq4a4u40 171 27 therapeutic therapeutic JJ cord-006608-mq4a4u40 171 28 intervention intervention NN cord-006608-mq4a4u40 171 29 [ [ -LRB- cord-006608-mq4a4u40 171 30 37• 37• CD cord-006608-mq4a4u40 171 31 ] ] -RRB- cord-006608-mq4a4u40 171 32 . . . cord-006608-mq4a4u40 172 1 Variation variation NN cord-006608-mq4a4u40 172 2 in in IN cord-006608-mq4a4u40 172 3 receptor receptor NN cord-006608-mq4a4u40 172 4 molecules molecule NNS cord-006608-mq4a4u40 172 5 is be VBZ cord-006608-mq4a4u40 172 6 one one CD cord-006608-mq4a4u40 172 7 explanation explanation NN cord-006608-mq4a4u40 172 8 for for IN cord-006608-mq4a4u40 172 9 the the DT cord-006608-mq4a4u40 172 10 spectrum spectrum NN cord-006608-mq4a4u40 172 11 of of IN cord-006608-mq4a4u40 172 12 illness illness NN cord-006608-mq4a4u40 172 13 observed observe VBN cord-006608-mq4a4u40 172 14 with with IN cord-006608-mq4a4u40 172 15 HPS HPS NNP cord-006608-mq4a4u40 172 16 [ [ -LRB- cord-006608-mq4a4u40 172 17 25• 25• CD cord-006608-mq4a4u40 172 18 ] ] -RRB- cord-006608-mq4a4u40 172 19 . . . cord-006608-mq4a4u40 173 1 Others other NNS cord-006608-mq4a4u40 173 2 include include VBP cord-006608-mq4a4u40 173 3 specific specific JJ cord-006608-mq4a4u40 173 4 viral viral JJ cord-006608-mq4a4u40 173 5 differences difference NNS cord-006608-mq4a4u40 173 6 , , , cord-006608-mq4a4u40 173 7 inoculum inoculum NN cord-006608-mq4a4u40 173 8 differences difference NNS cord-006608-mq4a4u40 173 9 , , , cord-006608-mq4a4u40 173 10 and and CC cord-006608-mq4a4u40 173 11 host host NN cord-006608-mq4a4u40 173 12 factors factor NNS cord-006608-mq4a4u40 173 13 , , , cord-006608-mq4a4u40 173 14 such such JJ cord-006608-mq4a4u40 173 15 as as IN cord-006608-mq4a4u40 173 16 HLA HLA NNP cord-006608-mq4a4u40 173 17 haplotype haplotype NN cord-006608-mq4a4u40 173 18 [ [ -LRB- cord-006608-mq4a4u40 173 19 38 38 CD cord-006608-mq4a4u40 173 20 ] ] -RRB- cord-006608-mq4a4u40 173 21 . . . cord-006608-mq4a4u40 174 1 Immunologic immunologic JJ cord-006608-mq4a4u40 174 2 responses response NNS cord-006608-mq4a4u40 174 3 mediating mediate VBG cord-006608-mq4a4u40 174 4 viral viral JJ cord-006608-mq4a4u40 174 5 clearance clearance NN cord-006608-mq4a4u40 174 6 and and CC cord-006608-mq4a4u40 174 7 recovery recovery NN cord-006608-mq4a4u40 174 8 from from IN cord-006608-mq4a4u40 174 9 HPS HPS NNP cord-006608-mq4a4u40 174 10 may may MD cord-006608-mq4a4u40 174 11 also also RB cord-006608-mq4a4u40 174 12 be be VB cord-006608-mq4a4u40 174 13 important important JJ cord-006608-mq4a4u40 174 14 . . . cord-006608-mq4a4u40 175 1 In in IN cord-006608-mq4a4u40 175 2 one one CD cord-006608-mq4a4u40 175 3 study study NN cord-006608-mq4a4u40 175 4 of of IN cord-006608-mq4a4u40 175 5 patients patient NNS cord-006608-mq4a4u40 175 6 with with IN cord-006608-mq4a4u40 175 7 HPS hps NN cord-006608-mq4a4u40 175 8 of of IN cord-006608-mq4a4u40 175 9 varying vary VBG cord-006608-mq4a4u40 175 10 clinical clinical JJ cord-006608-mq4a4u40 175 11 severity severity NN cord-006608-mq4a4u40 175 12 , , , cord-006608-mq4a4u40 175 13 neutralizing neutralize VBG cord-006608-mq4a4u40 175 14 antibody antibody NN cord-006608-mq4a4u40 175 15 titers titer NNS cord-006608-mq4a4u40 175 16 at at IN cord-006608-mq4a4u40 175 17 hospital hospital NN cord-006608-mq4a4u40 175 18 admission admission NN cord-006608-mq4a4u40 175 19 were be VBD cord-006608-mq4a4u40 175 20 lower low JJR cord-006608-mq4a4u40 175 21 in in IN cord-006608-mq4a4u40 175 22 patients patient NNS cord-006608-mq4a4u40 175 23 with with IN cord-006608-mq4a4u40 175 24 severe severe JJ cord-006608-mq4a4u40 175 25 disease disease NN cord-006608-mq4a4u40 175 26 ( ( -LRB- cord-006608-mq4a4u40 175 27 requiring require VBG cord-006608-mq4a4u40 175 28 intubation intubation NN cord-006608-mq4a4u40 175 29 ) ) -RRB- cord-006608-mq4a4u40 175 30 than than IN cord-006608-mq4a4u40 175 31 in in IN cord-006608-mq4a4u40 175 32 patients patient NNS cord-006608-mq4a4u40 175 33 with with IN cord-006608-mq4a4u40 175 34 mild mild JJ cord-006608-mq4a4u40 175 35 disease disease NN cord-006608-mq4a4u40 175 36 , , , cord-006608-mq4a4u40 175 37 suggesting suggest VBG cord-006608-mq4a4u40 175 38 a a DT cord-006608-mq4a4u40 175 39 role role NN cord-006608-mq4a4u40 175 40 for for IN cord-006608-mq4a4u40 175 41 immunotherapy immunotherapy NN cord-006608-mq4a4u40 175 42 [ [ -LRB- cord-006608-mq4a4u40 175 43 39 39 CD cord-006608-mq4a4u40 175 44 ] ] -RRB- cord-006608-mq4a4u40 175 45 . . . cord-006608-mq4a4u40 176 1 In in IN cord-006608-mq4a4u40 176 2 animal animal NN cord-006608-mq4a4u40 176 3 models model NNS cord-006608-mq4a4u40 176 4 , , , cord-006608-mq4a4u40 176 5 passive passive JJ cord-006608-mq4a4u40 176 6 administration administration NN cord-006608-mq4a4u40 176 7 of of IN cord-006608-mq4a4u40 176 8 immunoglobulin immunoglobulin NN cord-006608-mq4a4u40 176 9 after after IN cord-006608-mq4a4u40 176 10 exposure exposure NN cord-006608-mq4a4u40 176 11 protected protect VBN cord-006608-mq4a4u40 176 12 against against IN cord-006608-mq4a4u40 176 13 infection infection NN cord-006608-mq4a4u40 176 14 , , , cord-006608-mq4a4u40 176 15 but but CC cord-006608-mq4a4u40 176 16 no no DT cord-006608-mq4a4u40 176 17 human human JJ cord-006608-mq4a4u40 176 18 trials trial NNS cord-006608-mq4a4u40 176 19 have have VBP cord-006608-mq4a4u40 176 20 been be VBN cord-006608-mq4a4u40 176 21 performed perform VBN cord-006608-mq4a4u40 176 22 [ [ -LRB- cord-006608-mq4a4u40 176 23 15 15 CD cord-006608-mq4a4u40 176 24 ] ] -RRB- cord-006608-mq4a4u40 176 25 . . . cord-006608-mq4a4u40 177 1 The the DT cord-006608-mq4a4u40 177 2 prodrome prodrome NN cord-006608-mq4a4u40 177 3 of of IN cord-006608-mq4a4u40 177 4 HPS HPS NNP cord-006608-mq4a4u40 177 5 is be VBZ cord-006608-mq4a4u40 177 6 indistinguishable indistinguishable JJ cord-006608-mq4a4u40 177 7 from from IN cord-006608-mq4a4u40 177 8 other other JJ cord-006608-mq4a4u40 177 9 viral viral JJ cord-006608-mq4a4u40 177 10 infections infection NNS cord-006608-mq4a4u40 177 11 . . . cord-006608-mq4a4u40 178 1 Serologic Serologic NNP cord-006608-mq4a4u40 178 2 testing testing NN cord-006608-mq4a4u40 178 3 is be VBZ cord-006608-mq4a4u40 178 4 usually usually RB cord-006608-mq4a4u40 178 5 not not RB cord-006608-mq4a4u40 178 6 performed perform VBN cord-006608-mq4a4u40 178 7 until until IN cord-006608-mq4a4u40 178 8 respiratory respiratory JJ cord-006608-mq4a4u40 178 9 symptoms symptom NNS cord-006608-mq4a4u40 178 10 develop develop VBP cord-006608-mq4a4u40 178 11 , , , cord-006608-mq4a4u40 178 12 at at IN cord-006608-mq4a4u40 178 13 which which WDT cord-006608-mq4a4u40 178 14 point point NN cord-006608-mq4a4u40 178 15 progression progression NN cord-006608-mq4a4u40 178 16 to to IN cord-006608-mq4a4u40 178 17 death death NN cord-006608-mq4a4u40 178 18 can can MD cord-006608-mq4a4u40 178 19 be be VB cord-006608-mq4a4u40 178 20 rapid rapid JJ cord-006608-mq4a4u40 178 21 . . . cord-006608-mq4a4u40 179 1 Treatment treatment NN cord-006608-mq4a4u40 179 2 remains remain VBZ cord-006608-mq4a4u40 179 3 primarily primarily RB cord-006608-mq4a4u40 179 4 supportive supportive JJ cord-006608-mq4a4u40 179 5 , , , cord-006608-mq4a4u40 179 6 including include VBG cord-006608-mq4a4u40 179 7 attention attention NN cord-006608-mq4a4u40 179 8 to to IN cord-006608-mq4a4u40 179 9 proper proper JJ cord-006608-mq4a4u40 179 10 fluid fluid JJ cord-006608-mq4a4u40 179 11 administration administration NN cord-006608-mq4a4u40 179 12 and and CC cord-006608-mq4a4u40 179 13 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 179 14 support support NN cord-006608-mq4a4u40 179 15 . . . cord-006608-mq4a4u40 180 1 Antimicrobial antimicrobial JJ cord-006608-mq4a4u40 180 2 therapy therapy NN cord-006608-mq4a4u40 180 3 is be VBZ cord-006608-mq4a4u40 180 4 often often RB cord-006608-mq4a4u40 180 5 initiated initiate VBN cord-006608-mq4a4u40 180 6 for for IN cord-006608-mq4a4u40 180 7 other other JJ cord-006608-mq4a4u40 180 8 potentially potentially RB cord-006608-mq4a4u40 180 9 treatable treatable JJ cord-006608-mq4a4u40 180 10 diseases disease NNS cord-006608-mq4a4u40 180 11 in in IN cord-006608-mq4a4u40 180 12 the the DT cord-006608-mq4a4u40 180 13 differential differential JJ cord-006608-mq4a4u40 180 14 diagnosis diagnosis NN cord-006608-mq4a4u40 180 15 . . . cord-006608-mq4a4u40 181 1 An an DT cord-006608-mq4a4u40 181 2 open open JJ cord-006608-mq4a4u40 181 3 - - HYPH cord-006608-mq4a4u40 181 4 label label NN cord-006608-mq4a4u40 181 5 trial trial NN cord-006608-mq4a4u40 181 6 of of IN cord-006608-mq4a4u40 181 7 ribavirin ribavirin NN cord-006608-mq4a4u40 181 8 for for IN cord-006608-mq4a4u40 181 9 suspected suspect VBN cord-006608-mq4a4u40 181 10 HPS HPS NNP cord-006608-mq4a4u40 181 11 was be VBD cord-006608-mq4a4u40 181 12 conducted conduct VBN cord-006608-mq4a4u40 181 13 between between IN cord-006608-mq4a4u40 181 14 June June NNP cord-006608-mq4a4u40 181 15 1993 1993 CD cord-006608-mq4a4u40 181 16 and and CC cord-006608-mq4a4u40 181 17 September September NNP cord-006608-mq4a4u40 181 18 1 1 CD cord-006608-mq4a4u40 181 19 , , , cord-006608-mq4a4u40 181 20 1994 1994 CD cord-006608-mq4a4u40 181 21 . . . cord-006608-mq4a4u40 182 1 Ribavirin Ribavirin NNP cord-006608-mq4a4u40 182 2 was be VBD cord-006608-mq4a4u40 182 3 selected select VBN cord-006608-mq4a4u40 182 4 on on IN cord-006608-mq4a4u40 182 5 the the DT cord-006608-mq4a4u40 182 6 basis basis NN cord-006608-mq4a4u40 182 7 of of IN cord-006608-mq4a4u40 182 8 a a DT cord-006608-mq4a4u40 182 9 prospective prospective JJ cord-006608-mq4a4u40 182 10 , , , cord-006608-mq4a4u40 182 11 double double JJ cord-006608-mq4a4u40 182 12 - - HYPH cord-006608-mq4a4u40 182 13 blinded blinded JJ cord-006608-mq4a4u40 182 14 , , , cord-006608-mq4a4u40 182 15 placebo placebo NN cord-006608-mq4a4u40 182 16 - - HYPH cord-006608-mq4a4u40 182 17 controlled control VBN cord-006608-mq4a4u40 182 18 trial trial NN cord-006608-mq4a4u40 182 19 of of IN cord-006608-mq4a4u40 182 20 ribavirin ribavirin NN cord-006608-mq4a4u40 182 21 for for IN cord-006608-mq4a4u40 182 22 HFRS HFRS NNP cord-006608-mq4a4u40 182 23 in in IN cord-006608-mq4a4u40 182 24 China China NNP cord-006608-mq4a4u40 182 25 [ [ -LRB- cord-006608-mq4a4u40 182 26 40 40 CD cord-006608-mq4a4u40 182 27 ] ] -RRB- cord-006608-mq4a4u40 182 28 . . . cord-006608-mq4a4u40 183 1 This this DT cord-006608-mq4a4u40 183 2 study study NN cord-006608-mq4a4u40 183 3 suggested suggest VBD cord-006608-mq4a4u40 183 4 that that IN cord-006608-mq4a4u40 183 5 mortality mortality NN cord-006608-mq4a4u40 183 6 was be VBD cord-006608-mq4a4u40 183 7 lower low JJR cord-006608-mq4a4u40 183 8 if if IN cord-006608-mq4a4u40 183 9 the the DT cord-006608-mq4a4u40 183 10 drug drug NN cord-006608-mq4a4u40 183 11 was be VBD cord-006608-mq4a4u40 183 12 administered administer VBN cord-006608-mq4a4u40 183 13 within within IN cord-006608-mq4a4u40 183 14 4 4 CD cord-006608-mq4a4u40 183 15 days day NNS cord-006608-mq4a4u40 183 16 of of IN cord-006608-mq4a4u40 183 17 diagnosis diagnosis NN cord-006608-mq4a4u40 183 18 [ [ -LRB- cord-006608-mq4a4u40 183 19 40 40 CD cord-006608-mq4a4u40 183 20 ] ] -RRB- cord-006608-mq4a4u40 183 21 . . . cord-006608-mq4a4u40 184 1 The the DT cord-006608-mq4a4u40 184 2 investigators investigator NNS cord-006608-mq4a4u40 184 3 also also RB cord-006608-mq4a4u40 184 4 reported report VBD cord-006608-mq4a4u40 184 5 that that IN cord-006608-mq4a4u40 184 6 the the DT cord-006608-mq4a4u40 184 7 drug drug NN cord-006608-mq4a4u40 184 8 had have VBD cord-006608-mq4a4u40 184 9 an an DT cord-006608-mq4a4u40 184 10 acceptable acceptable JJ cord-006608-mq4a4u40 184 11 safety safety NN cord-006608-mq4a4u40 184 12 profile profile NN cord-006608-mq4a4u40 184 13 , , , cord-006608-mq4a4u40 184 14 and and CC cord-006608-mq4a4u40 184 15 they -PRON- PRP cord-006608-mq4a4u40 184 16 showed show VBD cord-006608-mq4a4u40 184 17 in in IN cord-006608-mq4a4u40 184 18 vitro vitro FW cord-006608-mq4a4u40 184 19 susceptibility susceptibility NN cord-006608-mq4a4u40 184 20 to to IN cord-006608-mq4a4u40 184 21 ribavirin ribavirin NN cord-006608-mq4a4u40 184 22 . . . cord-006608-mq4a4u40 185 1 The the DT cord-006608-mq4a4u40 185 2 study study NN cord-006608-mq4a4u40 185 3 enrolled enrol VBD cord-006608-mq4a4u40 185 4 140 140 CD cord-006608-mq4a4u40 185 5 patients patient NNS cord-006608-mq4a4u40 185 6 ; ; : cord-006608-mq4a4u40 185 7 hantavirus hantavirus NN cord-006608-mq4a4u40 185 8 infection infection NN cord-006608-mq4a4u40 185 9 was be VBD cord-006608-mq4a4u40 185 10 confirmed confirm VBN cord-006608-mq4a4u40 185 11 in in IN cord-006608-mq4a4u40 185 12 30 30 CD cord-006608-mq4a4u40 185 13 patients patient NNS cord-006608-mq4a4u40 185 14 , , , cord-006608-mq4a4u40 185 15 and and CC cord-006608-mq4a4u40 185 16 the the DT cord-006608-mq4a4u40 185 17 mortality mortality NN cord-006608-mq4a4u40 185 18 rate rate NN cord-006608-mq4a4u40 185 19 was be VBD cord-006608-mq4a4u40 185 20 47 47 CD cord-006608-mq4a4u40 185 21 % % NN cord-006608-mq4a4u40 185 22 . . . cord-006608-mq4a4u40 186 1 The the DT cord-006608-mq4a4u40 186 2 investigators investigator NNS cord-006608-mq4a4u40 186 3 could could MD cord-006608-mq4a4u40 186 4 not not RB cord-006608-mq4a4u40 186 5 assess assess VB cord-006608-mq4a4u40 186 6 the the DT cord-006608-mq4a4u40 186 7 efficacy efficacy NN cord-006608-mq4a4u40 186 8 of of IN cord-006608-mq4a4u40 186 9 intravenous intravenous JJ cord-006608-mq4a4u40 186 10 ribavirin ribavirin NN cord-006608-mq4a4u40 186 11 , , , cord-006608-mq4a4u40 186 12 but but CC cord-006608-mq4a4u40 186 13 comparison comparison NN cord-006608-mq4a4u40 186 14 of of IN cord-006608-mq4a4u40 186 15 the the DT cord-006608-mq4a4u40 186 16 30 30 CD cord-006608-mq4a4u40 186 17 study study NN cord-006608-mq4a4u40 186 18 patients patient NNS cord-006608-mq4a4u40 186 19 who who WP cord-006608-mq4a4u40 186 20 had have VBD cord-006608-mq4a4u40 186 21 HPS hps NN cord-006608-mq4a4u40 186 22 with with IN cord-006608-mq4a4u40 186 23 34 34 CD cord-006608-mq4a4u40 186 24 untreated untreated JJ cord-006608-mq4a4u40 186 25 patients patient NNS cord-006608-mq4a4u40 186 26 with with IN cord-006608-mq4a4u40 186 27 HPS hps NN cord-006608-mq4a4u40 186 28 who who WP cord-006608-mq4a4u40 186 29 were be VBD cord-006608-mq4a4u40 186 30 not not RB cord-006608-mq4a4u40 186 31 enrolled enrol VBN cord-006608-mq4a4u40 186 32 in in IN cord-006608-mq4a4u40 186 33 the the DT cord-006608-mq4a4u40 186 34 study study NN cord-006608-mq4a4u40 186 35 showed show VBD cord-006608-mq4a4u40 186 36 no no DT cord-006608-mq4a4u40 186 37 difference difference NN cord-006608-mq4a4u40 186 38 in in IN cord-006608-mq4a4u40 186 39 survival survival NN cord-006608-mq4a4u40 186 40 between between IN cord-006608-mq4a4u40 186 41 the the DT cord-006608-mq4a4u40 186 42 groups group NNS cord-006608-mq4a4u40 186 43 . . . cord-006608-mq4a4u40 187 1 Anemia anemia NN cord-006608-mq4a4u40 187 2 developed develop VBD cord-006608-mq4a4u40 187 3 in in IN cord-006608-mq4a4u40 187 4 71 71 CD cord-006608-mq4a4u40 187 5 % % NN cord-006608-mq4a4u40 187 6 of of IN cord-006608-mq4a4u40 187 7 patients patient NNS cord-006608-mq4a4u40 187 8 , , , cord-006608-mq4a4u40 187 9 19 19 CD cord-006608-mq4a4u40 187 10 % % NN cord-006608-mq4a4u40 187 11 of of IN cord-006608-mq4a4u40 187 12 whom whom WP cord-006608-mq4a4u40 187 13 had have VBD cord-006608-mq4a4u40 187 14 transfusion transfusion NN cord-006608-mq4a4u40 187 15 . . . cord-006608-mq4a4u40 188 1 In in IN cord-006608-mq4a4u40 188 2 1995 1995 CD cord-006608-mq4a4u40 188 3 , , , cord-006608-mq4a4u40 188 4 a a DT cord-006608-mq4a4u40 188 5 double double JJ cord-006608-mq4a4u40 188 6 - - HYPH cord-006608-mq4a4u40 188 7 blind blind JJ cord-006608-mq4a4u40 188 8 , , , cord-006608-mq4a4u40 188 9 placebo placebo NN cord-006608-mq4a4u40 188 10 - - HYPH cord-006608-mq4a4u40 188 11 controlled control VBN cord-006608-mq4a4u40 188 12 trial trial NN cord-006608-mq4a4u40 188 13 of of IN cord-006608-mq4a4u40 188 14 ribavirin ribavirin NN cord-006608-mq4a4u40 188 15 sponsored sponsor VBN cord-006608-mq4a4u40 188 16 by by IN cord-006608-mq4a4u40 188 17 the the DT cord-006608-mq4a4u40 188 18 National National NNP cord-006608-mq4a4u40 188 19 Institutes Institutes NNPS cord-006608-mq4a4u40 188 20 of of IN cord-006608-mq4a4u40 188 21 Health Health NNP cord-006608-mq4a4u40 188 22 , , , cord-006608-mq4a4u40 188 23 was be VBD cord-006608-mq4a4u40 188 24 initiated initiate VBN cord-006608-mq4a4u40 188 25 to to TO cord-006608-mq4a4u40 188 26 evaluate evaluate VB cord-006608-mq4a4u40 188 27 efficacy efficacy NN cord-006608-mq4a4u40 188 28 in in IN cord-006608-mq4a4u40 188 29 HPS HPS NNP cord-006608-mq4a4u40 188 30 . . . cord-006608-mq4a4u40 189 1 Patients patient NNS cord-006608-mq4a4u40 189 2 with with IN cord-006608-mq4a4u40 189 3 suspected suspect VBN cord-006608-mq4a4u40 189 4 HPS hps NN cord-006608-mq4a4u40 189 5 in in IN cord-006608-mq4a4u40 189 6 the the DT cord-006608-mq4a4u40 189 7 prodromal prodromal JJ cord-006608-mq4a4u40 189 8 as as RB cord-006608-mq4a4u40 189 9 well well RB cord-006608-mq4a4u40 189 10 as as IN cord-006608-mq4a4u40 189 11 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 189 12 stages stage NNS cord-006608-mq4a4u40 189 13 are be VBP cord-006608-mq4a4u40 189 14 eligible eligible JJ cord-006608-mq4a4u40 189 15 [ [ -LRB- cord-006608-mq4a4u40 189 16 15 15 CD cord-006608-mq4a4u40 189 17 , , , cord-006608-mq4a4u40 189 18 40 40 CD cord-006608-mq4a4u40 189 19 ] ] -RRB- cord-006608-mq4a4u40 189 20 . . . cord-006608-mq4a4u40 190 1 The the DT cord-006608-mq4a4u40 190 2 observation observation NN cord-006608-mq4a4u40 190 3 that that IN cord-006608-mq4a4u40 190 4 severe severe JJ cord-006608-mq4a4u40 190 5 cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 190 6 failure failure NN cord-006608-mq4a4u40 190 7 in in IN cord-006608-mq4a4u40 190 8 HPS hps NN cord-006608-mq4a4u40 190 9 is be VBZ cord-006608-mq4a4u40 190 10 reversible reversible JJ cord-006608-mq4a4u40 190 11 led lead VBN cord-006608-mq4a4u40 190 12 to to IN cord-006608-mq4a4u40 190 13 treatment treatment NN cord-006608-mq4a4u40 190 14 with with IN cord-006608-mq4a4u40 190 15 extracorporeal extracorporeal JJ cord-006608-mq4a4u40 190 16 membrane membrane NN cord-006608-mq4a4u40 190 17 oxygenation oxygenation NN cord-006608-mq4a4u40 190 18 ( ( -LRB- cord-006608-mq4a4u40 190 19 ECMO ECMO NNP cord-006608-mq4a4u40 190 20 ) ) -RRB- cord-006608-mq4a4u40 191 1 [ [ -LRB- cord-006608-mq4a4u40 191 2 41• 41• CD cord-006608-mq4a4u40 191 3 ] ] -RRB- cord-006608-mq4a4u40 191 4 . . . cord-006608-mq4a4u40 192 1 The the DT cord-006608-mq4a4u40 192 2 characteristic characteristic JJ cord-006608-mq4a4u40 192 3 rapid rapid JJ cord-006608-mq4a4u40 192 4 recovery recovery NN cord-006608-mq4a4u40 192 5 in in IN cord-006608-mq4a4u40 192 6 the the DT cord-006608-mq4a4u40 192 7 convalescent convalescent JJ cord-006608-mq4a4u40 192 8 stage stage NN cord-006608-mq4a4u40 192 9 would would MD cord-006608-mq4a4u40 192 10 only only RB cord-006608-mq4a4u40 192 11 require require VB cord-006608-mq4a4u40 192 12 a a DT cord-006608-mq4a4u40 192 13 short short JJ cord-006608-mq4a4u40 192 14 duration duration NN cord-006608-mq4a4u40 192 15 of of IN cord-006608-mq4a4u40 192 16 ECMO ECMO NNP cord-006608-mq4a4u40 192 17 , , , cord-006608-mq4a4u40 192 18 which which WDT cord-006608-mq4a4u40 192 19 has have VBZ cord-006608-mq4a4u40 192 20 its -PRON- PRP$ cord-006608-mq4a4u40 192 21 own own JJ cord-006608-mq4a4u40 192 22 related related JJ cord-006608-mq4a4u40 192 23 complications complication NNS cord-006608-mq4a4u40 192 24 . . . cord-006608-mq4a4u40 193 1 Inclusion inclusion NN cord-006608-mq4a4u40 193 2 criteria criterion NNS cord-006608-mq4a4u40 193 3 for for IN cord-006608-mq4a4u40 193 4 ECMO ecmo NN cord-006608-mq4a4u40 193 5 therapy therapy NN cord-006608-mq4a4u40 193 6 were be VBD cord-006608-mq4a4u40 193 7 risk risk NN cord-006608-mq4a4u40 193 8 factors factor NNS cord-006608-mq4a4u40 193 9 that that WDT cord-006608-mq4a4u40 193 10 have have VBP cord-006608-mq4a4u40 193 11 been be VBN cord-006608-mq4a4u40 193 12 shown show VBN cord-006608-mq4a4u40 193 13 to to TO cord-006608-mq4a4u40 193 14 be be VB cord-006608-mq4a4u40 193 15 associated associate VBN cord-006608-mq4a4u40 193 16 with with IN cord-006608-mq4a4u40 193 17 a a DT cord-006608-mq4a4u40 193 18 100 100 CD cord-006608-mq4a4u40 193 19 % % NN cord-006608-mq4a4u40 193 20 predicted predict VBN cord-006608-mq4a4u40 193 21 mortality mortality NN cord-006608-mq4a4u40 193 22 rate rate NN cord-006608-mq4a4u40 193 23 in in IN cord-006608-mq4a4u40 193 24 a a DT cord-006608-mq4a4u40 193 25 series series NN cord-006608-mq4a4u40 193 26 of of IN cord-006608-mq4a4u40 193 27 HPS hps NN cord-006608-mq4a4u40 193 28 - - HYPH cord-006608-mq4a4u40 193 29 related relate VBN cord-006608-mq4a4u40 193 30 deaths death NNS cord-006608-mq4a4u40 193 31 , , , cord-006608-mq4a4u40 193 32 including include VBG cord-006608-mq4a4u40 193 33 a a DT cord-006608-mq4a4u40 193 34 cardiac cardiac JJ cord-006608-mq4a4u40 193 35 index index NN cord-006608-mq4a4u40 193 36 less less JJR cord-006608-mq4a4u40 193 37 than than IN cord-006608-mq4a4u40 193 38 2.5 2.5 CD cord-006608-mq4a4u40 193 39 L L NNP cord-006608-mq4a4u40 193 40 / / SYM cord-006608-mq4a4u40 193 41 min min NN cord-006608-mq4a4u40 193 42 / / SYM cord-006608-mq4a4u40 193 43 mm mm NN cord-006608-mq4a4u40 193 44 , , , cord-006608-mq4a4u40 193 45 lactate lactate NN cord-006608-mq4a4u40 193 46 level level NN cord-006608-mq4a4u40 193 47 greater great JJR cord-006608-mq4a4u40 193 48 than than IN cord-006608-mq4a4u40 193 49 4 4 CD cord-006608-mq4a4u40 193 50 mmol mmol JJ cord-006608-mq4a4u40 193 51 / / SYM cord-006608-mq4a4u40 193 52 L l NN cord-006608-mq4a4u40 193 53 , , , cord-006608-mq4a4u40 193 54 ventricular ventricular JJ cord-006608-mq4a4u40 193 55 fibrillation fibrillation NN cord-006608-mq4a4u40 193 56 or or CC cord-006608-mq4a4u40 193 57 tachycardia tachycardia NN cord-006608-mq4a4u40 193 58 , , , cord-006608-mq4a4u40 193 59 pulseless pulseless JJ cord-006608-mq4a4u40 193 60 electrical electrical JJ cord-006608-mq4a4u40 193 61 activity activity NN cord-006608-mq4a4u40 193 62 , , , cord-006608-mq4a4u40 193 63 or or CC cord-006608-mq4a4u40 193 64 refractory refractory JJ cord-006608-mq4a4u40 193 65 shock shock NN cord-006608-mq4a4u40 193 66 . . . cord-006608-mq4a4u40 194 1 Patients patient NNS cord-006608-mq4a4u40 194 2 with with IN cord-006608-mq4a4u40 194 3 irreversible irreversible JJ cord-006608-mq4a4u40 194 4 neurologic neurologic JJ cord-006608-mq4a4u40 194 5 or or CC cord-006608-mq4a4u40 194 6 multiorgan multiorgan NN cord-006608-mq4a4u40 194 7 failure failure NN cord-006608-mq4a4u40 194 8 or or CC cord-006608-mq4a4u40 194 9 those those DT cord-006608-mq4a4u40 194 10 on on IN cord-006608-mq4a4u40 194 11 prolonged prolong VBN cord-006608-mq4a4u40 194 12 ventilation ventilation NN cord-006608-mq4a4u40 194 13 were be VBD cord-006608-mq4a4u40 194 14 generally generally RB cord-006608-mq4a4u40 194 15 excluded exclude VBN cord-006608-mq4a4u40 194 16 . . . cord-006608-mq4a4u40 195 1 Between between IN cord-006608-mq4a4u40 195 2 1994 1994 CD cord-006608-mq4a4u40 195 3 and and CC cord-006608-mq4a4u40 195 4 1995 1995 CD cord-006608-mq4a4u40 195 5 , , , cord-006608-mq4a4u40 195 6 ECMO ECMO NNP cord-006608-mq4a4u40 195 7 successfully successfully RB cord-006608-mq4a4u40 195 8 provided provide VBD cord-006608-mq4a4u40 195 9 support support NN cord-006608-mq4a4u40 195 10 in in IN cord-006608-mq4a4u40 195 11 two two CD cord-006608-mq4a4u40 195 12 patients patient NNS cord-006608-mq4a4u40 195 13 with with IN cord-006608-mq4a4u40 195 14 HPS HPS NNP cord-006608-mq4a4u40 195 15 . . . cord-006608-mq4a4u40 196 1 A a DT cord-006608-mq4a4u40 196 2 third third JJ cord-006608-mq4a4u40 196 3 eligible eligible JJ cord-006608-mq4a4u40 196 4 patient patient NN cord-006608-mq4a4u40 196 5 developed develop VBD cord-006608-mq4a4u40 196 6 ventricular ventricular JJ cord-006608-mq4a4u40 196 7 fibrillation fibrillation NN cord-006608-mq4a4u40 196 8 before before IN cord-006608-mq4a4u40 196 9 transfer transfer NN cord-006608-mq4a4u40 196 10 to to IN cord-006608-mq4a4u40 196 11 the the DT cord-006608-mq4a4u40 196 12 ECMO ECMO NNP cord-006608-mq4a4u40 196 13 unit unit NN cord-006608-mq4a4u40 196 14 and and CC cord-006608-mq4a4u40 196 15 died die VBD cord-006608-mq4a4u40 196 16 . . . cord-006608-mq4a4u40 197 1 The the DT cord-006608-mq4a4u40 197 2 hemodynamic hemodynamic JJ cord-006608-mq4a4u40 197 3 improvement improvement NN cord-006608-mq4a4u40 197 4 in in IN cord-006608-mq4a4u40 197 5 the the DT cord-006608-mq4a4u40 197 6 two two CD cord-006608-mq4a4u40 197 7 survivors survivor NNS cord-006608-mq4a4u40 197 8 was be VBD cord-006608-mq4a4u40 197 9 dramatic dramatic JJ cord-006608-mq4a4u40 197 10 in in IN cord-006608-mq4a4u40 197 11 the the DT cord-006608-mq4a4u40 197 12 first first JJ cord-006608-mq4a4u40 197 13 12 12 CD cord-006608-mq4a4u40 197 14 hours hour NNS cord-006608-mq4a4u40 197 15 of of IN cord-006608-mq4a4u40 197 16 ECMO ECMO NNP cord-006608-mq4a4u40 197 17 . . . cord-006608-mq4a4u40 198 1 Both both DT cord-006608-mq4a4u40 198 2 patients patient NNS cord-006608-mq4a4u40 198 3 were be VBD cord-006608-mq4a4u40 198 4 weaned wean VBN cord-006608-mq4a4u40 198 5 off off IN cord-006608-mq4a4u40 198 6 the the DT cord-006608-mq4a4u40 198 7 ventilator ventilator NN cord-006608-mq4a4u40 198 8 within within IN cord-006608-mq4a4u40 198 9 4 4 CD cord-006608-mq4a4u40 198 10 to to TO cord-006608-mq4a4u40 198 11 5 5 CD cord-006608-mq4a4u40 198 12 days day NNS cord-006608-mq4a4u40 198 13 . . . cord-006608-mq4a4u40 199 1 Early early JJ cord-006608-mq4a4u40 199 2 transfer transfer NN cord-006608-mq4a4u40 199 3 of of IN cord-006608-mq4a4u40 199 4 patients patient NNS cord-006608-mq4a4u40 199 5 with with IN cord-006608-mq4a4u40 199 6 HPS HPS NNP cord-006608-mq4a4u40 199 7 to to IN cord-006608-mq4a4u40 199 8 a a DT cord-006608-mq4a4u40 199 9 center center NN cord-006608-mq4a4u40 199 10 offering offering NN cord-006608-mq4a4u40 199 11 ECMO ECMO NNP cord-006608-mq4a4u40 199 12 should should MD cord-006608-mq4a4u40 199 13 be be VB cord-006608-mq4a4u40 199 14 considered consider VBN cord-006608-mq4a4u40 199 15 . . . cord-006608-mq4a4u40 200 1 A a DT cord-006608-mq4a4u40 200 2 16-year 16-year JJ cord-006608-mq4a4u40 200 3 - - HYPH cord-006608-mq4a4u40 200 4 old old JJ cord-006608-mq4a4u40 200 5 boy boy NN cord-006608-mq4a4u40 200 6 with with IN cord-006608-mq4a4u40 200 7 HPS HPS NNP cord-006608-mq4a4u40 200 8 was be VBD cord-006608-mq4a4u40 200 9 successfully successfully RB cord-006608-mq4a4u40 200 10 treated treat VBN cord-006608-mq4a4u40 200 11 with with IN cord-006608-mq4a4u40 200 12 inhaled inhale VBN cord-006608-mq4a4u40 200 13 nitric nitric NN cord-006608-mq4a4u40 200 14 oxide oxide NN cord-006608-mq4a4u40 200 15 [ [ -LRB- cord-006608-mq4a4u40 200 16 42 42 CD cord-006608-mq4a4u40 200 17 ] ] -RRB- cord-006608-mq4a4u40 200 18 . . . cord-006608-mq4a4u40 201 1 Oxygenation oxygenation NN cord-006608-mq4a4u40 201 2 in in IN cord-006608-mq4a4u40 201 3 this this DT cord-006608-mq4a4u40 201 4 patient patient NN cord-006608-mq4a4u40 201 5 rapidly rapidly RB cord-006608-mq4a4u40 201 6 improved improve VBD cord-006608-mq4a4u40 201 7 , , , cord-006608-mq4a4u40 201 8 and and CC cord-006608-mq4a4u40 201 9 the the DT cord-006608-mq4a4u40 201 10 boy boy NN cord-006608-mq4a4u40 201 11 was be VBD cord-006608-mq4a4u40 201 12 extubated extubate VBN cord-006608-mq4a4u40 201 13 43 43 CD cord-006608-mq4a4u40 201 14 hours hour NNS cord-006608-mq4a4u40 201 15 after after IN cord-006608-mq4a4u40 201 16 initiation initiation NN cord-006608-mq4a4u40 201 17 of of IN cord-006608-mq4a4u40 201 18 therapy therapy NN cord-006608-mq4a4u40 201 19 . . . cord-006608-mq4a4u40 202 1 Nitric nitric NN cord-006608-mq4a4u40 202 2 oxide oxide NN cord-006608-mq4a4u40 202 3 is be VBZ cord-006608-mq4a4u40 202 4 a a DT cord-006608-mq4a4u40 202 5 potent potent JJ cord-006608-mq4a4u40 202 6 vascular vascular JJ cord-006608-mq4a4u40 202 7 relaxant relaxant NN cord-006608-mq4a4u40 202 8 . . . cord-006608-mq4a4u40 203 1 Local local JJ cord-006608-mq4a4u40 203 2 administration administration NN cord-006608-mq4a4u40 203 3 delivers deliver VBZ cord-006608-mq4a4u40 203 4 it -PRON- PRP cord-006608-mq4a4u40 203 5 directly directly RB cord-006608-mq4a4u40 203 6 to to IN cord-006608-mq4a4u40 203 7 the the DT cord-006608-mq4a4u40 203 8 pulmonary pulmonary JJ cord-006608-mq4a4u40 203 9 vascular vascular JJ cord-006608-mq4a4u40 203 10 epithelium epithelium NN cord-006608-mq4a4u40 203 11 , , , cord-006608-mq4a4u40 203 12 leading lead VBG cord-006608-mq4a4u40 203 13 to to IN cord-006608-mq4a4u40 203 14 reduced reduce VBN cord-006608-mq4a4u40 203 15 pulmonary pulmonary JJ cord-006608-mq4a4u40 203 16 artery artery NN cord-006608-mq4a4u40 203 17 pressure pressure NN cord-006608-mq4a4u40 203 18 ; ; : cord-006608-mq4a4u40 203 19 this this DT cord-006608-mq4a4u40 203 20 may may MD cord-006608-mq4a4u40 203 21 be be VB cord-006608-mq4a4u40 203 22 the the DT cord-006608-mq4a4u40 203 23 mechanism mechanism NN cord-006608-mq4a4u40 203 24 that that WDT cord-006608-mq4a4u40 203 25 improves improve VBZ cord-006608-mq4a4u40 203 26 pulmonary pulmonary JJ cord-006608-mq4a4u40 203 27 edema edema NN cord-006608-mq4a4u40 203 28 . . . cord-006608-mq4a4u40 204 1 Although although IN cord-006608-mq4a4u40 204 2 it -PRON- PRP cord-006608-mq4a4u40 204 3 is be VBZ cord-006608-mq4a4u40 204 4 difficult difficult JJ cord-006608-mq4a4u40 204 5 to to TO cord-006608-mq4a4u40 204 6 reach reach VB cord-006608-mq4a4u40 204 7 any any DT cord-006608-mq4a4u40 204 8 conclusions conclusion NNS cord-006608-mq4a4u40 204 9 about about IN cord-006608-mq4a4u40 204 10 efficacy efficacy NN cord-006608-mq4a4u40 204 11 of of IN cord-006608-mq4a4u40 204 12 nitric nitric NN cord-006608-mq4a4u40 204 13 oxide oxide NN cord-006608-mq4a4u40 204 14 on on IN cord-006608-mq4a4u40 204 15 the the DT cord-006608-mq4a4u40 204 16 basis basis NN cord-006608-mq4a4u40 204 17 of of IN cord-006608-mq4a4u40 204 18 a a DT cord-006608-mq4a4u40 204 19 single single JJ cord-006608-mq4a4u40 204 20 case case NN cord-006608-mq4a4u40 204 21 report report NN cord-006608-mq4a4u40 204 22 , , , cord-006608-mq4a4u40 204 23 this this DT cord-006608-mq4a4u40 204 24 may may MD cord-006608-mq4a4u40 204 25 be be VB cord-006608-mq4a4u40 204 26 a a DT cord-006608-mq4a4u40 204 27 modality modality NN cord-006608-mq4a4u40 204 28 for for IN cord-006608-mq4a4u40 204 29 future future JJ cord-006608-mq4a4u40 204 30 study study NN cord-006608-mq4a4u40 204 31 . . . cord-006608-mq4a4u40 205 1 Limiting limit VBG cord-006608-mq4a4u40 205 2 exposure exposure NN cord-006608-mq4a4u40 205 3 to to IN cord-006608-mq4a4u40 205 4 rodents rodent NNS cord-006608-mq4a4u40 205 5 and and CC cord-006608-mq4a4u40 205 6 excreta excreta NN cord-006608-mq4a4u40 205 7 is be VBZ cord-006608-mq4a4u40 205 8 the the DT cord-006608-mq4a4u40 205 9 most most RBS cord-006608-mq4a4u40 205 10 effective effective JJ cord-006608-mq4a4u40 205 11 way way NN cord-006608-mq4a4u40 205 12 to to TO cord-006608-mq4a4u40 205 13 decrease decrease VB cord-006608-mq4a4u40 205 14 the the DT cord-006608-mq4a4u40 205 15 risk risk NN cord-006608-mq4a4u40 205 16 of of IN cord-006608-mq4a4u40 205 17 HPS HPS NNP cord-006608-mq4a4u40 205 18 . . . cord-006608-mq4a4u40 206 1 Elimination elimination NN cord-006608-mq4a4u40 206 2 of of IN cord-006608-mq4a4u40 206 3 food food NN cord-006608-mq4a4u40 206 4 sources source NNS cord-006608-mq4a4u40 206 5 and and CC cord-006608-mq4a4u40 206 6 nesting nest VBG cord-006608-mq4a4u40 206 7 sites site NNS cord-006608-mq4a4u40 206 8 for for IN cord-006608-mq4a4u40 206 9 rodents rodent NNS cord-006608-mq4a4u40 206 10 is be VBZ cord-006608-mq4a4u40 206 11 crucial crucial JJ cord-006608-mq4a4u40 206 12 . . . cord-006608-mq4a4u40 207 1 Rodenticides rodenticide NNS cord-006608-mq4a4u40 207 2 are be VBP cord-006608-mq4a4u40 207 3 useful useful JJ cord-006608-mq4a4u40 207 4 , , , cord-006608-mq4a4u40 207 5 but but CC cord-006608-mq4a4u40 207 6 fleas flea NNS cord-006608-mq4a4u40 207 7 should should MD cord-006608-mq4a4u40 207 8 be be VB cord-006608-mq4a4u40 207 9 eliminated eliminate VBN cord-006608-mq4a4u40 207 10 first first RB cord-006608-mq4a4u40 207 11 in in IN cord-006608-mq4a4u40 207 12 plague plague NN cord-006608-mq4a4u40 207 13 - - HYPH cord-006608-mq4a4u40 207 14 endemic endemic JJ cord-006608-mq4a4u40 207 15 regions region NNS cord-006608-mq4a4u40 207 16 . . . cord-006608-mq4a4u40 208 1 Areas area NNS cord-006608-mq4a4u40 208 2 where where WRB cord-006608-mq4a4u40 208 3 rodent rodent NN cord-006608-mq4a4u40 208 4 infestation infestation NN cord-006608-mq4a4u40 208 5 is be VBZ cord-006608-mq4a4u40 208 6 suspected suspect VBN cord-006608-mq4a4u40 208 7 should should MD cord-006608-mq4a4u40 208 8 be be VB cord-006608-mq4a4u40 208 9 well well RB cord-006608-mq4a4u40 208 10 ventilated ventilate VBN cord-006608-mq4a4u40 208 11 before before IN cord-006608-mq4a4u40 208 12 humans human NNS cord-006608-mq4a4u40 208 13 enter enter VBP cord-006608-mq4a4u40 208 14 . . . cord-006608-mq4a4u40 209 1 Brooms broom NNS cord-006608-mq4a4u40 209 2 or or CC cord-006608-mq4a4u40 209 3 vacuums vacuum NNS cord-006608-mq4a4u40 209 4 should should MD cord-006608-mq4a4u40 209 5 be be VB cord-006608-mq4a4u40 209 6 avoided avoid VBN cord-006608-mq4a4u40 209 7 to to TO cord-006608-mq4a4u40 209 8 prevent prevent VB cord-006608-mq4a4u40 209 9 aerosolization aerosolization NN cord-006608-mq4a4u40 209 10 of of IN cord-006608-mq4a4u40 209 11 potentially potentially RB cord-006608-mq4a4u40 209 12 infected infect VBN cord-006608-mq4a4u40 209 13 rodent rodent NN cord-006608-mq4a4u40 209 14 excreta excreta NN cord-006608-mq4a4u40 209 15 . . . cord-006608-mq4a4u40 210 1 The the DT cord-006608-mq4a4u40 210 2 Centers Centers NNPS cord-006608-mq4a4u40 210 3 for for IN cord-006608-mq4a4u40 210 4 Disease Disease NNP cord-006608-mq4a4u40 210 5 Control Control NNP cord-006608-mq4a4u40 210 6 and and CC cord-006608-mq4a4u40 210 7 Prevention Prevention NNP cord-006608-mq4a4u40 210 8 has have VBZ cord-006608-mq4a4u40 210 9 published publish VBN cord-006608-mq4a4u40 210 10 detailed detailed JJ cord-006608-mq4a4u40 210 11 recommendations recommendation NNS cord-006608-mq4a4u40 210 12 for for IN cord-006608-mq4a4u40 210 13 the the DT cord-006608-mq4a4u40 210 14 prevention prevention NN cord-006608-mq4a4u40 210 15 of of IN cord-006608-mq4a4u40 210 16 HPS HPS NNP cord-006608-mq4a4u40 210 17 [ [ -LRB- cord-006608-mq4a4u40 210 18 43 43 CD cord-006608-mq4a4u40 210 19 ] ] -RRB- cord-006608-mq4a4u40 210 20 . . . cord-006608-mq4a4u40 211 1 Vaccines vaccine NNS cord-006608-mq4a4u40 211 2 for for IN cord-006608-mq4a4u40 211 3 hantavirus hantavirus NN cord-006608-mq4a4u40 211 4 infections infection NNS cord-006608-mq4a4u40 211 5 have have VBP cord-006608-mq4a4u40 211 6 been be VBN cord-006608-mq4a4u40 211 7 developed develop VBN cord-006608-mq4a4u40 211 8 against against IN cord-006608-mq4a4u40 211 9 strains strain NNS cord-006608-mq4a4u40 211 10 associated associate VBN cord-006608-mq4a4u40 211 11 with with IN cord-006608-mq4a4u40 211 12 the the DT cord-006608-mq4a4u40 211 13 HFRS HFRS NNP cord-006608-mq4a4u40 211 14 form form NN cord-006608-mq4a4u40 211 15 of of IN cord-006608-mq4a4u40 211 16 disease disease NN cord-006608-mq4a4u40 211 17 . . . cord-006608-mq4a4u40 212 1 An an DT cord-006608-mq4a4u40 212 2 inactivated inactivate VBN cord-006608-mq4a4u40 212 3 Hantaan Hantaan NNP cord-006608-mq4a4u40 212 4 virus virus NN cord-006608-mq4a4u40 212 5 vaccine vaccine NN cord-006608-mq4a4u40 212 6 is be VBZ cord-006608-mq4a4u40 212 7 licensed license VBN cord-006608-mq4a4u40 212 8 for for IN cord-006608-mq4a4u40 212 9 use use NN cord-006608-mq4a4u40 212 10 in in IN cord-006608-mq4a4u40 212 11 Korea Korea NNP cord-006608-mq4a4u40 212 12 . . . cord-006608-mq4a4u40 213 1 In in IN cord-006608-mq4a4u40 213 2 one one CD cord-006608-mq4a4u40 213 3 study study NN cord-006608-mq4a4u40 213 4 , , , cord-006608-mq4a4u40 213 5 75 75 CD cord-006608-mq4a4u40 213 6 % % NN cord-006608-mq4a4u40 213 7 of of IN cord-006608-mq4a4u40 213 8 patients patient NNS cord-006608-mq4a4u40 213 9 receiving receive VBG cord-006608-mq4a4u40 213 10 this this DT cord-006608-mq4a4u40 213 11 vaccine vaccine NN cord-006608-mq4a4u40 213 12 produced produce VBD cord-006608-mq4a4u40 213 13 neutralizing neutralize VBG cord-006608-mq4a4u40 213 14 antibody antibody NN cord-006608-mq4a4u40 213 15 after after IN cord-006608-mq4a4u40 213 16 the the DT cord-006608-mq4a4u40 213 17 first first JJ cord-006608-mq4a4u40 213 18 booster booster NN cord-006608-mq4a4u40 213 19 dose dose NN cord-006608-mq4a4u40 213 20 ; ; : cord-006608-mq4a4u40 213 21 however however RB cord-006608-mq4a4u40 213 22 , , , cord-006608-mq4a4u40 213 23 the the DT cord-006608-mq4a4u40 213 24 humoral humoral JJ cord-006608-mq4a4u40 213 25 response response NN cord-006608-mq4a4u40 213 26 was be VBD cord-006608-mq4a4u40 213 27 short short RB cord-006608-mq4a4u40 213 28 - - HYPH cord-006608-mq4a4u40 213 29 lived live VBN cord-006608-mq4a4u40 213 30 [ [ -LRB- cord-006608-mq4a4u40 213 31 44 44 CD cord-006608-mq4a4u40 213 32 ] ] -RRB- cord-006608-mq4a4u40 213 33 . . . cord-006608-mq4a4u40 214 1 Hantaviral Hantaviral NNP cord-006608-mq4a4u40 214 2 G1 G1 NNP cord-006608-mq4a4u40 214 3 , , , cord-006608-mq4a4u40 214 4 G2 G2 NNP cord-006608-mq4a4u40 214 5 , , , cord-006608-mq4a4u40 214 6 and and CC cord-006608-mq4a4u40 214 7 nucleocapsid nucleocapsid NN cord-006608-mq4a4u40 214 8 proteins protein NNS cord-006608-mq4a4u40 214 9 are be VBP cord-006608-mq4a4u40 214 10 known know VBN cord-006608-mq4a4u40 214 11 to to TO cord-006608-mq4a4u40 214 12 be be VB cord-006608-mq4a4u40 214 13 immunogenic immunogenic JJ cord-006608-mq4a4u40 214 14 . . . cord-006608-mq4a4u40 215 1 This this DT cord-006608-mq4a4u40 215 2 finding finding NN cord-006608-mq4a4u40 215 3 has have VBZ cord-006608-mq4a4u40 215 4 prompted prompt VBN cord-006608-mq4a4u40 215 5 interest interest NN cord-006608-mq4a4u40 215 6 in in IN cord-006608-mq4a4u40 215 7 developing develop VBG cord-006608-mq4a4u40 215 8 recombinant recombinant JJ cord-006608-mq4a4u40 215 9 vaccines vaccine NNS cord-006608-mq4a4u40 215 10 using use VBG cord-006608-mq4a4u40 215 11 baculovirus baculovirus NN cord-006608-mq4a4u40 215 12 and and CC cord-006608-mq4a4u40 215 13 vaccinia vaccinia NN cord-006608-mq4a4u40 215 14 - - HYPH cord-006608-mq4a4u40 215 15 expressed express VBN cord-006608-mq4a4u40 215 16 glycoproteins glycoprotein NNS cord-006608-mq4a4u40 215 17 . . . cord-006608-mq4a4u40 216 1 In in IN cord-006608-mq4a4u40 216 2 rodents rodent NNS cord-006608-mq4a4u40 216 3 , , , cord-006608-mq4a4u40 216 4 these these DT cord-006608-mq4a4u40 216 5 vaccines vaccine NNS cord-006608-mq4a4u40 216 6 could could MD cord-006608-mq4a4u40 216 7 elicit elicit VB cord-006608-mq4a4u40 216 8 neutralizing neutralize VBG cord-006608-mq4a4u40 216 9 antibody antibody NN cord-006608-mq4a4u40 216 10 responses response NNS cord-006608-mq4a4u40 216 11 and and CC cord-006608-mq4a4u40 216 12 protect protect VB cord-006608-mq4a4u40 216 13 against against IN cord-006608-mq4a4u40 216 14 Hantaan Hantaan NNP cord-006608-mq4a4u40 216 15 virus virus NN cord-006608-mq4a4u40 216 16 infection infection NN cord-006608-mq4a4u40 216 17 [ [ -LRB- cord-006608-mq4a4u40 216 18 45 45 CD cord-006608-mq4a4u40 216 19 ] ] -RRB- cord-006608-mq4a4u40 216 20 [ [ -LRB- cord-006608-mq4a4u40 216 21 46 46 CD cord-006608-mq4a4u40 216 22 ] ] -RRB- cord-006608-mq4a4u40 216 23 [ [ -LRB- cord-006608-mq4a4u40 216 24 47 47 CD cord-006608-mq4a4u40 216 25 ] ] -RRB- cord-006608-mq4a4u40 216 26 . . . cord-006608-mq4a4u40 217 1 Additional additional JJ cord-006608-mq4a4u40 217 2 studies study NNS cord-006608-mq4a4u40 217 3 using use VBG cord-006608-mq4a4u40 217 4 recombinant recombinant JJ cord-006608-mq4a4u40 217 5 DNA dna NN cord-006608-mq4a4u40 217 6 vaccines vaccine NNS cord-006608-mq4a4u40 217 7 in in IN cord-006608-mq4a4u40 217 8 animal animal NN cord-006608-mq4a4u40 217 9 models model NNS cord-006608-mq4a4u40 217 10 have have VBP cord-006608-mq4a4u40 217 11 shown show VBN cord-006608-mq4a4u40 217 12 similar similar JJ cord-006608-mq4a4u40 217 13 success success NN cord-006608-mq4a4u40 217 14 . . . cord-006608-mq4a4u40 218 1 In in IN cord-006608-mq4a4u40 218 2 rodent rodent NN cord-006608-mq4a4u40 218 3 studies study NNS cord-006608-mq4a4u40 218 4 , , , cord-006608-mq4a4u40 218 5 use use NN cord-006608-mq4a4u40 218 6 of of IN cord-006608-mq4a4u40 218 7 either either DT cord-006608-mq4a4u40 218 8 Seoul Seoul NNP cord-006608-mq4a4u40 218 9 virus virus NN cord-006608-mq4a4u40 218 10 M M NNP cord-006608-mq4a4u40 218 11 or or CC cord-006608-mq4a4u40 218 12 S S NNP cord-006608-mq4a4u40 218 13 genome genome NN cord-006608-mq4a4u40 218 14 segments segment NNS cord-006608-mq4a4u40 218 15 in in IN cord-006608-mq4a4u40 218 16 DNA dna NN cord-006608-mq4a4u40 218 17 vaccines vaccine NNS cord-006608-mq4a4u40 218 18 elicited elicit VBD cord-006608-mq4a4u40 218 19 Seoul Seoul NNP cord-006608-mq4a4u40 218 20 - - HYPH cord-006608-mq4a4u40 218 21 specific specific JJ cord-006608-mq4a4u40 218 22 neutralizing neutralize VBG cord-006608-mq4a4u40 218 23 antibody antibody NN cord-006608-mq4a4u40 218 24 responses response NNS cord-006608-mq4a4u40 218 25 ; ; : cord-006608-mq4a4u40 218 26 however however RB cord-006608-mq4a4u40 218 27 , , , cord-006608-mq4a4u40 218 28 only only RB cord-006608-mq4a4u40 218 29 M M NNP cord-006608-mq4a4u40 218 30 segment segment NN cord-006608-mq4a4u40 218 31 vaccination vaccination NN cord-006608-mq4a4u40 218 32 protected protect VBD cord-006608-mq4a4u40 218 33 rodents rodent NNS cord-006608-mq4a4u40 218 34 from from IN cord-006608-mq4a4u40 218 35 infection infection NN cord-006608-mq4a4u40 218 36 [ [ -LRB- cord-006608-mq4a4u40 218 37 48 48 CD cord-006608-mq4a4u40 218 38 ] ] -RRB- cord-006608-mq4a4u40 218 39 . . . cord-006608-mq4a4u40 219 1 DNA DNA NNP cord-006608-mq4a4u40 219 2 vaccines vaccine NNS cord-006608-mq4a4u40 219 3 against against IN cord-006608-mq4a4u40 219 4 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 219 5 that that WDT cord-006608-mq4a4u40 219 6 cause cause VB cord-006608-mq4a4u40 219 7 HPS HPS NNP cord-006608-mq4a4u40 219 8 are be VBP cord-006608-mq4a4u40 219 9 being be VBG cord-006608-mq4a4u40 219 10 developed develop VBN cord-006608-mq4a4u40 219 11 [ [ -LRB- cord-006608-mq4a4u40 219 12 7 7 CD cord-006608-mq4a4u40 219 13 ] ] -RRB- cord-006608-mq4a4u40 219 14 . . . cord-006608-mq4a4u40 220 1 The the DT cord-006608-mq4a4u40 220 2 discovery discovery NN cord-006608-mq4a4u40 220 3 of of IN cord-006608-mq4a4u40 220 4 HPS HPS NNP cord-006608-mq4a4u40 220 5 in in IN cord-006608-mq4a4u40 220 6 1993 1993 CD cord-006608-mq4a4u40 220 7 was be VBD cord-006608-mq4a4u40 220 8 followed follow VBN cord-006608-mq4a4u40 220 9 by by IN cord-006608-mq4a4u40 220 10 a a DT cord-006608-mq4a4u40 220 11 rapid rapid JJ cord-006608-mq4a4u40 220 12 accumulation accumulation NN cord-006608-mq4a4u40 220 13 of of IN cord-006608-mq4a4u40 220 14 information information NN cord-006608-mq4a4u40 220 15 . . . cord-006608-mq4a4u40 221 1 Within within IN cord-006608-mq4a4u40 221 2 weeks week NNS cord-006608-mq4a4u40 221 3 of of IN cord-006608-mq4a4u40 221 4 recognition recognition NN cord-006608-mq4a4u40 221 5 of of IN cord-006608-mq4a4u40 221 6 this this DT cord-006608-mq4a4u40 221 7 syndrome syndrome NN cord-006608-mq4a4u40 221 8 , , , cord-006608-mq4a4u40 221 9 the the DT cord-006608-mq4a4u40 221 10 etiologic etiologic JJ cord-006608-mq4a4u40 221 11 agent agent NN cord-006608-mq4a4u40 221 12 and and CC cord-006608-mq4a4u40 221 13 its -PRON- PRP$ cord-006608-mq4a4u40 221 14 reservoir reservoir NN cord-006608-mq4a4u40 221 15 in in IN cord-006608-mq4a4u40 221 16 nature nature NN cord-006608-mq4a4u40 221 17 were be VBD cord-006608-mq4a4u40 221 18 identified identify VBN cord-006608-mq4a4u40 221 19 , , , cord-006608-mq4a4u40 221 20 and and CC cord-006608-mq4a4u40 221 21 a a DT cord-006608-mq4a4u40 221 22 trial trial NN cord-006608-mq4a4u40 221 23 of of IN cord-006608-mq4a4u40 221 24 a a DT cord-006608-mq4a4u40 221 25 potential potential JJ cord-006608-mq4a4u40 221 26 therapeutic therapeutic JJ cord-006608-mq4a4u40 221 27 agent agent NN cord-006608-mq4a4u40 221 28 was be VBD cord-006608-mq4a4u40 221 29 initiated initiate VBN cord-006608-mq4a4u40 221 30 . . . cord-006608-mq4a4u40 222 1 New new JJ cord-006608-mq4a4u40 222 2 viruses virus NNS cord-006608-mq4a4u40 222 3 continue continue VBP cord-006608-mq4a4u40 222 4 to to TO cord-006608-mq4a4u40 222 5 be be VB cord-006608-mq4a4u40 222 6 discovered discover VBN cord-006608-mq4a4u40 222 7 in in IN cord-006608-mq4a4u40 222 8 both both DT cord-006608-mq4a4u40 222 9 humans human NNS cord-006608-mq4a4u40 222 10 and and CC cord-006608-mq4a4u40 222 11 rodents rodent NNS cord-006608-mq4a4u40 222 12 throughout throughout IN cord-006608-mq4a4u40 222 13 the the DT cord-006608-mq4a4u40 222 14 Americas Americas NNPS cord-006608-mq4a4u40 222 15 , , , cord-006608-mq4a4u40 222 16 and and CC cord-006608-mq4a4u40 222 17 milder mild JJR cord-006608-mq4a4u40 222 18 forms form NNS cord-006608-mq4a4u40 222 19 of of IN cord-006608-mq4a4u40 222 20 disease disease NN cord-006608-mq4a4u40 222 21 are be VBP cord-006608-mq4a4u40 222 22 now now RB cord-006608-mq4a4u40 222 23 recognized recognize VBN cord-006608-mq4a4u40 222 24 . . . cord-006608-mq4a4u40 223 1 With with IN cord-006608-mq4a4u40 223 2 the the DT cord-006608-mq4a4u40 223 3 discovery discovery NN cord-006608-mq4a4u40 223 4 of of IN cord-006608-mq4a4u40 223 5 new new JJ cord-006608-mq4a4u40 223 6 viruses virus NNS cord-006608-mq4a4u40 223 7 , , , cord-006608-mq4a4u40 223 8 questions question NNS cord-006608-mq4a4u40 223 9 continue continue VBP cord-006608-mq4a4u40 223 10 to to TO cord-006608-mq4a4u40 223 11 arise arise VB cord-006608-mq4a4u40 223 12 about about IN cord-006608-mq4a4u40 223 13 the the DT cord-006608-mq4a4u40 223 14 spectrum spectrum NN cord-006608-mq4a4u40 223 15 of of IN cord-006608-mq4a4u40 223 16 clinical clinical JJ cord-006608-mq4a4u40 223 17 illness illness NN cord-006608-mq4a4u40 223 18 , , , cord-006608-mq4a4u40 223 19 routes route NNS cord-006608-mq4a4u40 223 20 of of IN cord-006608-mq4a4u40 223 21 transmission transmission NN cord-006608-mq4a4u40 223 22 , , , cord-006608-mq4a4u40 223 23 the the DT cord-006608-mq4a4u40 223 24 role role NN cord-006608-mq4a4u40 223 25 of of IN cord-006608-mq4a4u40 223 26 the the DT cord-006608-mq4a4u40 223 27 immune immune JJ cord-006608-mq4a4u40 223 28 system system NN cord-006608-mq4a4u40 223 29 in in IN cord-006608-mq4a4u40 223 30 pathogenesis pathogenesis NN cord-006608-mq4a4u40 223 31 , , , cord-006608-mq4a4u40 223 32 and and CC cord-006608-mq4a4u40 223 33 future future JJ cord-006608-mq4a4u40 223 34 treatment treatment NN cord-006608-mq4a4u40 223 35 . . . cord-006608-mq4a4u40 224 1 Papers paper NNS cord-006608-mq4a4u40 224 2 of of IN cord-006608-mq4a4u40 224 3 particular particular JJ cord-006608-mq4a4u40 224 4 interest interest NN cord-006608-mq4a4u40 224 5 , , , cord-006608-mq4a4u40 224 6 published publish VBN cord-006608-mq4a4u40 224 7 recently recently RB cord-006608-mq4a4u40 224 8 , , , cord-006608-mq4a4u40 224 9 have have VBP cord-006608-mq4a4u40 224 10 been be VBN cord-006608-mq4a4u40 224 11 highlighted highlight VBN cord-006608-mq4a4u40 224 12 as as IN cord-006608-mq4a4u40 224 13 : : : cord-006608-mq4a4u40 224 14 • • . cord-006608-mq4a4u40 225 1 Of of IN cord-006608-mq4a4u40 225 2 importance importance NN cord-006608-mq4a4u40 225 3 •• •• CD cord-006608-mq4a4u40 226 1 Of of IN cord-006608-mq4a4u40 226 2 major major JJ cord-006608-mq4a4u40 226 3 importance importance NN cord-006608-mq4a4u40 226 4 Isolation isolation NN cord-006608-mq4a4u40 226 5 of of IN cord-006608-mq4a4u40 226 6 the the DT cord-006608-mq4a4u40 226 7 causative causative JJ cord-006608-mq4a4u40 226 8 agent agent NN cord-006608-mq4a4u40 226 9 of of IN cord-006608-mq4a4u40 226 10 hantavirus hantavirus NN cord-006608-mq4a4u40 226 11 pulmonary pulmonary JJ cord-006608-mq4a4u40 226 12 syndrome syndrome NN cord-006608-mq4a4u40 226 13 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 226 14 pulmonary pulmonary JJ cord-006608-mq4a4u40 226 15 syndrome syndrome NN cord-006608-mq4a4u40 226 16 : : : cord-006608-mq4a4u40 226 17 a a DT cord-006608-mq4a4u40 226 18 clinical clinical JJ cord-006608-mq4a4u40 226 19 description description NN cord-006608-mq4a4u40 226 20 of of IN cord-006608-mq4a4u40 226 21 17 17 CD cord-006608-mq4a4u40 226 22 patients patient NNS cord-006608-mq4a4u40 226 23 with with IN cord-006608-mq4a4u40 226 24 a a DT cord-006608-mq4a4u40 226 25 newly newly RB cord-006608-mq4a4u40 226 26 recognized recognize VBN cord-006608-mq4a4u40 226 27 disease disease NN cord-006608-mq4a4u40 226 28 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 226 29 pulmonary pulmonary JJ cord-006608-mq4a4u40 226 30 syndrome syndrome NN cord-006608-mq4a4u40 226 31 : : : cord-006608-mq4a4u40 226 32 the the DT cord-006608-mq4a4u40 226 33 first first JJ cord-006608-mq4a4u40 226 34 100 100 CD cord-006608-mq4a4u40 226 35 US US NNP cord-006608-mq4a4u40 226 36 cases case NNS cord-006608-mq4a4u40 226 37 Isolation Isolation NNP cord-006608-mq4a4u40 226 38 of of IN cord-006608-mq4a4u40 226 39 Black Black NNP cord-006608-mq4a4u40 226 40 Creek Creek NNP cord-006608-mq4a4u40 226 41 Canal Canal NNP cord-006608-mq4a4u40 226 42 virus virus NN cord-006608-mq4a4u40 226 43 , , , cord-006608-mq4a4u40 226 44 a a DT cord-006608-mq4a4u40 226 45 new new JJ cord-006608-mq4a4u40 226 46 hantavirus hantavirus NN cord-006608-mq4a4u40 226 47 from from IN cord-006608-mq4a4u40 226 48 Sigmodon Sigmodon NNP cord-006608-mq4a4u40 226 49 hispidus hispidus NN cord-006608-mq4a4u40 226 50 in in IN cord-006608-mq4a4u40 226 51 Florida Florida NNP cord-006608-mq4a4u40 227 1 A a DT cord-006608-mq4a4u40 227 2 fatal fatal JJ cord-006608-mq4a4u40 227 3 illness illness NN cord-006608-mq4a4u40 227 4 associated associate VBN cord-006608-mq4a4u40 227 5 with with IN cord-006608-mq4a4u40 227 6 a a DT cord-006608-mq4a4u40 227 7 new new JJ cord-006608-mq4a4u40 227 8 hantavirus hantavirus NN cord-006608-mq4a4u40 227 9 in in IN cord-006608-mq4a4u40 227 10 Louisiana Louisiana NNP cord-006608-mq4a4u40 227 11 New New NNP cord-006608-mq4a4u40 227 12 York York NNP cord-006608-mq4a4u40 227 13 1 1 CD cord-006608-mq4a4u40 227 14 and and CC cord-006608-mq4a4u40 227 15 Sin Sin NNP cord-006608-mq4a4u40 227 16 Nombre Nombre NNP cord-006608-mq4a4u40 228 1 viruses virus NNS cord-006608-mq4a4u40 228 2 are be VBP cord-006608-mq4a4u40 228 3 serotypically serotypically RB cord-006608-mq4a4u40 228 4 distinct distinct JJ cord-006608-mq4a4u40 228 5 viruses virus NNS cord-006608-mq4a4u40 228 6 associated associate VBN cord-006608-mq4a4u40 228 7 with with IN cord-006608-mq4a4u40 228 8 hantavirus hantavirus NN cord-006608-mq4a4u40 228 9 pulmonary pulmonary JJ cord-006608-mq4a4u40 228 10 syndrome syndrome NN cord-006608-mq4a4u40 228 11 Hantaviruses Hantaviruses NNP cord-006608-mq4a4u40 228 12 : : : cord-006608-mq4a4u40 228 13 a a DT cord-006608-mq4a4u40 228 14 global global JJ cord-006608-mq4a4u40 228 15 disease disease NN cord-006608-mq4a4u40 228 16 problem problem NN cord-006608-mq4a4u40 228 17 Naturally naturally RB cord-006608-mq4a4u40 228 18 occurring occur VBG cord-006608-mq4a4u40 228 19 Sin Sin NNP cord-006608-mq4a4u40 228 20 Nombre Nombre NNP cord-006608-mq4a4u40 228 21 virus virus NN cord-006608-mq4a4u40 228 22 genetic genetic JJ cord-006608-mq4a4u40 228 23 reassortments reassortment NNS cord-006608-mq4a4u40 228 24 Complete complete VBP cord-006608-mq4a4u40 228 25 nucleotide nucleotide JJ cord-006608-mq4a4u40 228 26 sequences sequence NNS cord-006608-mq4a4u40 228 27 of of IN cord-006608-mq4a4u40 228 28 the the DT cord-006608-mq4a4u40 228 29 M M NNP cord-006608-mq4a4u40 228 30 and and CC cord-006608-mq4a4u40 228 31 S S NNP cord-006608-mq4a4u40 228 32 segments segment NNS cord-006608-mq4a4u40 228 33 of of IN cord-006608-mq4a4u40 228 34 two two CD cord-006608-mq4a4u40 228 35 hantavirus hantavirus NN cord-006608-mq4a4u40 228 36 isolates isolate NNS cord-006608-mq4a4u40 228 37 from from IN cord-006608-mq4a4u40 228 38 California California NNP cord-006608-mq4a4u40 228 39 : : : cord-006608-mq4a4u40 228 40 evidence evidence NN cord-006608-mq4a4u40 228 41 for for IN cord-006608-mq4a4u40 228 42 reassortment reassortment NN cord-006608-mq4a4u40 228 43 in in IN cord-006608-mq4a4u40 228 44 nature nature NN cord-006608-mq4a4u40 228 45 among among IN cord-006608-mq4a4u40 228 46 viruses virus NNS cord-006608-mq4a4u40 228 47 related relate VBN cord-006608-mq4a4u40 228 48 to to IN cord-006608-mq4a4u40 228 49 hantavirus hantavirus NN cord-006608-mq4a4u40 228 50 pulmonary pulmonary JJ cord-006608-mq4a4u40 228 51 syndrome syndrome NN cord-006608-mq4a4u40 228 52 Genetic genetic JJ cord-006608-mq4a4u40 228 53 reassortment reassortment NN cord-006608-mq4a4u40 228 54 among among IN cord-006608-mq4a4u40 228 55 viruses virus NNS cord-006608-mq4a4u40 228 56 causing cause VBG cord-006608-mq4a4u40 228 57 hantavirus hantavirus NN cord-006608-mq4a4u40 228 58 pulmonary pulmonary JJ cord-006608-mq4a4u40 228 59 syndrome syndrome NN cord-006608-mq4a4u40 228 60 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 228 61 infections infection NNS cord-006608-mq4a4u40 228 62 : : : cord-006608-mq4a4u40 228 63 epidemiology epidemiology NN cord-006608-mq4a4u40 228 64 and and CC cord-006608-mq4a4u40 228 65 pathogenesis pathogenesis NN cord-006608-mq4a4u40 229 1 This this DT cord-006608-mq4a4u40 229 2 review review NN cord-006608-mq4a4u40 229 3 focuses focus VBZ cord-006608-mq4a4u40 229 4 on on IN cord-006608-mq4a4u40 229 5 the the DT cord-006608-mq4a4u40 229 6 virology virology NN cord-006608-mq4a4u40 229 7 , , , cord-006608-mq4a4u40 229 8 ecology ecology NN cord-006608-mq4a4u40 229 9 , , , cord-006608-mq4a4u40 229 10 and and CC cord-006608-mq4a4u40 229 11 transmission transmission NN cord-006608-mq4a4u40 229 12 of of IN cord-006608-mq4a4u40 229 13 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 230 1 This this DT cord-006608-mq4a4u40 230 2 is be VBZ cord-006608-mq4a4u40 230 3 an an DT cord-006608-mq4a4u40 230 4 excellent excellent JJ cord-006608-mq4a4u40 230 5 comprehensive comprehensive JJ cord-006608-mq4a4u40 230 6 review review NN cord-006608-mq4a4u40 230 7 of of IN cord-006608-mq4a4u40 230 8 hantaviral hantaviral JJ cord-006608-mq4a4u40 230 9 infections infection NNS cord-006608-mq4a4u40 230 10 , , , cord-006608-mq4a4u40 230 11 including include VBG cord-006608-mq4a4u40 230 12 a a DT cord-006608-mq4a4u40 230 13 discussion discussion NN cord-006608-mq4a4u40 230 14 of of IN cord-006608-mq4a4u40 230 15 evidence evidence NN cord-006608-mq4a4u40 230 16 of of IN cord-006608-mq4a4u40 230 17 hantaviral hantaviral JJ cord-006608-mq4a4u40 230 18 infection infection NN cord-006608-mq4a4u40 230 19 in in IN cord-006608-mq4a4u40 230 20 the the DT cord-006608-mq4a4u40 230 21 British British NNP cord-006608-mq4a4u40 230 22 Isles Isles NNP cord-006608-mq4a4u40 230 23 Long long JJ cord-006608-mq4a4u40 230 24 - - HYPH cord-006608-mq4a4u40 230 25 term term NN cord-006608-mq4a4u40 230 26 studies study NNS cord-006608-mq4a4u40 230 27 of of IN cord-006608-mq4a4u40 230 28 hantavirus hantavirus NN cord-006608-mq4a4u40 230 29 reservoir reservoir NN cord-006608-mq4a4u40 230 30 populations population NNS cord-006608-mq4a4u40 230 31 in in IN cord-006608-mq4a4u40 230 32 the the DT cord-006608-mq4a4u40 230 33 Southwestern Southwestern NNP cord-006608-mq4a4u40 230 34 United United NNP cord-006608-mq4a4u40 230 35 States States NNP cord-006608-mq4a4u40 230 36 : : : cord-006608-mq4a4u40 230 37 a a DT cord-006608-mq4a4u40 230 38 synthesis synthesis NN cord-006608-mq4a4u40 230 39 Persistent persistent JJ cord-006608-mq4a4u40 230 40 hantavirus hantavirus NN cord-006608-mq4a4u40 230 41 infections infection NNS cord-006608-mq4a4u40 230 42 : : : cord-006608-mq4a4u40 230 43 characteristics characteristic NNS cord-006608-mq4a4u40 230 44 and and CC cord-006608-mq4a4u40 230 45 mechanisms mechanism NNS cord-006608-mq4a4u40 230 46 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 230 47 infection infection NN cord-006608-mq4a4u40 230 48 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 230 49 pulmonary pulmonary JJ cord-006608-mq4a4u40 230 50 syndrome syndrome NN cord-006608-mq4a4u40 230 51 Hantaviruses Hantaviruses NNP cord-006608-mq4a4u40 230 52 and and CC cord-006608-mq4a4u40 230 53 hantavirus hantavirus NN cord-006608-mq4a4u40 230 54 pulmonary pulmonary JJ cord-006608-mq4a4u40 230 55 syndrome syndrome NN cord-006608-mq4a4u40 230 56 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 230 57 pulmonary pulmonary JJ cord-006608-mq4a4u40 230 58 syndrome syndrome NN cord-006608-mq4a4u40 230 59 in in IN cord-006608-mq4a4u40 230 60 pregnancy pregnancy NN cord-006608-mq4a4u40 230 61 Evidence evidence NN cord-006608-mq4a4u40 230 62 against against IN cord-006608-mq4a4u40 230 63 person person NN cord-006608-mq4a4u40 230 64 - - HYPH cord-006608-mq4a4u40 230 65 to to IN cord-006608-mq4a4u40 230 66 - - HYPH cord-006608-mq4a4u40 230 67 person person NN cord-006608-mq4a4u40 230 68 transmission transmission NN cord-006608-mq4a4u40 230 69 of of IN cord-006608-mq4a4u40 230 70 hantavirus hantavirus NN cord-006608-mq4a4u40 230 71 to to TO cord-006608-mq4a4u40 230 72 health health NN cord-006608-mq4a4u40 230 73 care care NN cord-006608-mq4a4u40 230 74 workers worker NNS cord-006608-mq4a4u40 231 1 A a DT cord-006608-mq4a4u40 231 2 case case NN cord-006608-mq4a4u40 231 3 - - HYPH cord-006608-mq4a4u40 231 4 control control NN cord-006608-mq4a4u40 231 5 study study NN cord-006608-mq4a4u40 231 6 of of IN cord-006608-mq4a4u40 231 7 hantavirus hantavirus NNP cord-006608-mq4a4u40 231 8 pulmonary pulmonary JJ cord-006608-mq4a4u40 231 9 syndrome syndrome NN cord-006608-mq4a4u40 231 10 during during IN cord-006608-mq4a4u40 231 11 an an DT cord-006608-mq4a4u40 231 12 outbreak outbreak NN cord-006608-mq4a4u40 231 13 in in IN cord-006608-mq4a4u40 231 14 the the DT cord-006608-mq4a4u40 231 15 southwestern southwestern JJ cord-006608-mq4a4u40 231 16 United United NNP cord-006608-mq4a4u40 231 17 States States NNP cord-006608-mq4a4u40 231 18 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 231 19 pulmonary pulmonary JJ cord-006608-mq4a4u40 231 20 syndrome syndrome NN cord-006608-mq4a4u40 231 21 outbreak outbreak NN cord-006608-mq4a4u40 231 22 in in IN cord-006608-mq4a4u40 231 23 Argentina Argentina NNP cord-006608-mq4a4u40 231 24 : : : cord-006608-mq4a4u40 231 25 molecular molecular JJ cord-006608-mq4a4u40 231 26 evidence evidence NN cord-006608-mq4a4u40 231 27 for for IN cord-006608-mq4a4u40 231 28 person person NN cord-006608-mq4a4u40 231 29 - - : cord-006608-mq4a4u40 231 30 to to IN cord-006608-mq4a4u40 231 31 person person NN cord-006608-mq4a4u40 231 32 transmission transmission NN cord-006608-mq4a4u40 231 33 of of IN cord-006608-mq4a4u40 231 34 Andes Andes NNP cord-006608-mq4a4u40 231 35 virus virus NN cord-006608-mq4a4u40 232 1 This this DT cord-006608-mq4a4u40 232 2 interesting interesting JJ cord-006608-mq4a4u40 232 3 study study NN cord-006608-mq4a4u40 232 4 investigates investigate VBZ cord-006608-mq4a4u40 232 5 an an DT cord-006608-mq4a4u40 232 6 outbreak outbreak NN cord-006608-mq4a4u40 232 7 of of IN cord-006608-mq4a4u40 232 8 HPS HPS NNP cord-006608-mq4a4u40 232 9 in in IN cord-006608-mq4a4u40 232 10 Argentina Argentina NNP cord-006608-mq4a4u40 232 11 . . . cord-006608-mq4a4u40 233 1 The the DT cord-006608-mq4a4u40 233 2 authors author NNS cord-006608-mq4a4u40 233 3 conclude conclude VBP cord-006608-mq4a4u40 233 4 that that IN cord-006608-mq4a4u40 233 5 person person NN cord-006608-mq4a4u40 233 6 - - HYPH cord-006608-mq4a4u40 233 7 to to IN cord-006608-mq4a4u40 233 8 - - HYPH cord-006608-mq4a4u40 233 9 person person NN cord-006608-mq4a4u40 233 10 transmission transmission NN cord-006608-mq4a4u40 233 11 has have VBZ cord-006608-mq4a4u40 233 12 been be VBN cord-006608-mq4a4u40 233 13 demonstrated demonstrate VBN cord-006608-mq4a4u40 233 14 using use VBG cord-006608-mq4a4u40 233 15 comparative comparative JJ cord-006608-mq4a4u40 233 16 analysis analysis NN cord-006608-mq4a4u40 233 17 between between IN cord-006608-mq4a4u40 233 18 different different JJ cord-006608-mq4a4u40 233 19 viral viral JJ cord-006608-mq4a4u40 233 20 sequences sequence NNS cord-006608-mq4a4u40 233 21 from from IN cord-006608-mq4a4u40 233 22 human human JJ cord-006608-mq4a4u40 233 23 cases case NNS cord-006608-mq4a4u40 233 24 . . . cord-006608-mq4a4u40 234 1 22 22 CD cord-006608-mq4a4u40 234 2 . . . cord-006608-mq4a4u40 235 1 Centers center NNS cord-006608-mq4a4u40 235 2 for for IN cord-006608-mq4a4u40 235 3 Disease Disease NNP cord-006608-mq4a4u40 235 4 Control Control NNP cord-006608-mq4a4u40 235 5 and and CC cord-006608-mq4a4u40 235 6 Prevention Prevention NNP cord-006608-mq4a4u40 235 7 : : : cord-006608-mq4a4u40 236 1 All all DT cord-006608-mq4a4u40 236 2 about about IN cord-006608-mq4a4u40 236 3 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 237 1 An an DT cord-006608-mq4a4u40 237 2 outbreak outbreak NN cord-006608-mq4a4u40 237 3 of of IN cord-006608-mq4a4u40 237 4 hantavirus hantavirus NN cord-006608-mq4a4u40 237 5 pulmonary pulmonary JJ cord-006608-mq4a4u40 237 6 syndrome syndrome NN cord-006608-mq4a4u40 237 7 in in IN cord-006608-mq4a4u40 237 8 Chile Chile NNP cord-006608-mq4a4u40 237 9 Evaluation Evaluation NNP cord-006608-mq4a4u40 237 10 of of IN cord-006608-mq4a4u40 237 11 the the DT cord-006608-mq4a4u40 237 12 magnitude magnitude NN cord-006608-mq4a4u40 237 13 of of IN cord-006608-mq4a4u40 237 14 the the DT cord-006608-mq4a4u40 237 15 1993 1993 CD cord-006608-mq4a4u40 237 16 hantavirus hantavirus NN cord-006608-mq4a4u40 237 17 outbreak outbreak NN cord-006608-mq4a4u40 237 18 in in IN cord-006608-mq4a4u40 237 19 the the DT cord-006608-mq4a4u40 237 20 southwestern southwestern JJ cord-006608-mq4a4u40 237 21 United United NNP cord-006608-mq4a4u40 237 22 States States NNP cord-006608-mq4a4u40 237 23 Acute Acute NNP cord-006608-mq4a4u40 237 24 Sin Sin NNP cord-006608-mq4a4u40 237 25 Nombre Nombre NNP cord-006608-mq4a4u40 237 26 hantavirus hantavirus NN cord-006608-mq4a4u40 237 27 infection infection NN cord-006608-mq4a4u40 237 28 without without IN cord-006608-mq4a4u40 237 29 pulmonary pulmonary JJ cord-006608-mq4a4u40 237 30 syndrome syndrome NN cord-006608-mq4a4u40 237 31 , , , cord-006608-mq4a4u40 237 32 United United NNP cord-006608-mq4a4u40 237 33 States States NNP cord-006608-mq4a4u40 238 1 This this DT cord-006608-mq4a4u40 238 2 is be VBZ cord-006608-mq4a4u40 238 3 an an DT cord-006608-mq4a4u40 238 4 important important JJ cord-006608-mq4a4u40 238 5 case case NN cord-006608-mq4a4u40 238 6 series series NN cord-006608-mq4a4u40 238 7 of of IN cord-006608-mq4a4u40 238 8 five five CD cord-006608-mq4a4u40 238 9 patients patient NNS cord-006608-mq4a4u40 238 10 identified identify VBN cord-006608-mq4a4u40 238 11 in in IN cord-006608-mq4a4u40 238 12 the the DT cord-006608-mq4a4u40 238 13 United United NNP cord-006608-mq4a4u40 238 14 States States NNP cord-006608-mq4a4u40 238 15 with with IN cord-006608-mq4a4u40 238 16 acute acute JJ cord-006608-mq4a4u40 238 17 SNV SNV NNP cord-006608-mq4a4u40 238 18 infection infection NN cord-006608-mq4a4u40 238 19 that that WDT cord-006608-mq4a4u40 238 20 did do VBD cord-006608-mq4a4u40 238 21 not not RB cord-006608-mq4a4u40 238 22 fit fit VB cord-006608-mq4a4u40 238 23 the the DT cord-006608-mq4a4u40 238 24 HPS HPS NNP cord-006608-mq4a4u40 238 25 case case NN cord-006608-mq4a4u40 238 26 definition definition NN cord-006608-mq4a4u40 238 27 . . . cord-006608-mq4a4u40 239 1 These these DT cord-006608-mq4a4u40 239 2 cases case NNS cord-006608-mq4a4u40 239 3 established establish VBD cord-006608-mq4a4u40 239 4 the the DT cord-006608-mq4a4u40 239 5 presence presence NN cord-006608-mq4a4u40 239 6 of of IN cord-006608-mq4a4u40 239 7 milder mild JJR cord-006608-mq4a4u40 239 8 clinical clinical JJ cord-006608-mq4a4u40 239 9 illness illness NN cord-006608-mq4a4u40 240 1 Cardiopulmonary cardiopulmonary JJ cord-006608-mq4a4u40 240 2 manifestations manifestation NNS cord-006608-mq4a4u40 240 3 of of IN cord-006608-mq4a4u40 240 4 hantavirus hantavirus NN cord-006608-mq4a4u40 240 5 pulmonary pulmonary JJ cord-006608-mq4a4u40 240 6 syndrome syndrome NN cord-006608-mq4a4u40 240 7 Pleural Pleural NNP cord-006608-mq4a4u40 240 8 fluid fluid JJ cord-006608-mq4a4u40 240 9 characteristics characteristic NNS cord-006608-mq4a4u40 240 10 in in IN cord-006608-mq4a4u40 240 11 hantavirus hantavirus NN cord-006608-mq4a4u40 240 12 pulmonary pulmonary JJ cord-006608-mq4a4u40 240 13 syndrome syndrome NN cord-006608-mq4a4u40 240 14 Clinical Clinical NNP cord-006608-mq4a4u40 240 15 features feature VBZ cord-006608-mq4a4u40 240 16 that that WDT cord-006608-mq4a4u40 240 17 differentiate differentiate VBP cord-006608-mq4a4u40 240 18 hantavirus hantavirus NN cord-006608-mq4a4u40 240 19 pulmonary pulmonary JJ cord-006608-mq4a4u40 240 20 syndrome syndrome NN cord-006608-mq4a4u40 240 21 from from IN cord-006608-mq4a4u40 240 22 three three CD cord-006608-mq4a4u40 240 23 other other JJ cord-006608-mq4a4u40 240 24 acute acute JJ cord-006608-mq4a4u40 240 25 respiratory respiratory JJ cord-006608-mq4a4u40 240 26 illnesses illness NNS cord-006608-mq4a4u40 240 27 Neuropsychological neuropsychological JJ cord-006608-mq4a4u40 240 28 impairments impairment NNS cord-006608-mq4a4u40 240 29 following follow VBG cord-006608-mq4a4u40 240 30 hantavirus hantavirus NN cord-006608-mq4a4u40 240 31 pulmonary pulmonary JJ cord-006608-mq4a4u40 240 32 syndrome syndrome NN cord-006608-mq4a4u40 240 33 High high JJ cord-006608-mq4a4u40 240 34 levels level NNS cord-006608-mq4a4u40 240 35 of of IN cord-006608-mq4a4u40 240 36 viremia viremia NN cord-006608-mq4a4u40 240 37 in in IN cord-006608-mq4a4u40 240 38 patients patient NNS cord-006608-mq4a4u40 240 39 with with IN cord-006608-mq4a4u40 240 40 hantavirus hantavirus NN cord-006608-mq4a4u40 240 41 pulmonary pulmonary JJ cord-006608-mq4a4u40 240 42 syndrome syndrome NN cord-006608-mq4a4u40 240 43 Spectrum Spectrum NNP cord-006608-mq4a4u40 240 44 of of IN cord-006608-mq4a4u40 240 45 hantavirus hantavirus NN cord-006608-mq4a4u40 240 46 infection infection NN cord-006608-mq4a4u40 240 47 : : : cord-006608-mq4a4u40 240 48 hemorrhagic hemorrhagic JJ cord-006608-mq4a4u40 240 49 fever fever NN cord-006608-mq4a4u40 240 50 with with IN cord-006608-mq4a4u40 240 51 renal renal JJ cord-006608-mq4a4u40 240 52 syndrome syndrome NN cord-006608-mq4a4u40 240 53 and and CC cord-006608-mq4a4u40 240 54 hantavirus hantavirus NN cord-006608-mq4a4u40 240 55 pulmonary pulmonary JJ cord-006608-mq4a4u40 240 56 syndrome syndrome NN cord-006608-mq4a4u40 241 1 This this DT cord-006608-mq4a4u40 241 2 is be VBZ cord-006608-mq4a4u40 241 3 an an DT cord-006608-mq4a4u40 241 4 excellent excellent JJ cord-006608-mq4a4u40 241 5 review review NN cord-006608-mq4a4u40 241 6 of of IN cord-006608-mq4a4u40 241 7 the the DT cord-006608-mq4a4u40 241 8 clinical clinical JJ cord-006608-mq4a4u40 241 9 spectrum spectrum NN cord-006608-mq4a4u40 241 10 of of IN cord-006608-mq4a4u40 241 11 disease disease NN cord-006608-mq4a4u40 241 12 and and CC cord-006608-mq4a4u40 241 13 pathogenesis pathogenesis NN cord-006608-mq4a4u40 241 14 of of IN cord-006608-mq4a4u40 241 15 hantaviral hantaviral JJ cord-006608-mq4a4u40 241 16 infections infection NNS cord-006608-mq4a4u40 241 17 Characterization characterization NN cord-006608-mq4a4u40 241 18 of of IN cord-006608-mq4a4u40 241 19 human human JJ cord-006608-mq4a4u40 241 20 antibody antibody NN cord-006608-mq4a4u40 241 21 responses response NNS cord-006608-mq4a4u40 241 22 to to IN cord-006608-mq4a4u40 241 23 Four four CD cord-006608-mq4a4u40 241 24 Corners Corners NNPS cord-006608-mq4a4u40 241 25 hantavirus hantavirus NN cord-006608-mq4a4u40 241 26 infection infection NN cord-006608-mq4a4u40 241 27 among among IN cord-006608-mq4a4u40 241 28 patients patient NNS cord-006608-mq4a4u40 241 29 with with IN cord-006608-mq4a4u40 241 30 hantavirus hantavirus NN cord-006608-mq4a4u40 241 31 pulmonary pulmonary JJ cord-006608-mq4a4u40 241 32 syndrome syndrome NN cord-006608-mq4a4u40 241 33 Rapid Rapid NNP cord-006608-mq4a4u40 241 34 and and CC cord-006608-mq4a4u40 241 35 specific specific JJ cord-006608-mq4a4u40 241 36 detection detection NN cord-006608-mq4a4u40 241 37 of of IN cord-006608-mq4a4u40 241 38 Sin Sin NNP cord-006608-mq4a4u40 241 39 Nombre Nombre NNP cord-006608-mq4a4u40 241 40 virus virus NN cord-006608-mq4a4u40 241 41 antibodies antibody NNS cord-006608-mq4a4u40 241 42 in in IN cord-006608-mq4a4u40 241 43 patients patient NNS cord-006608-mq4a4u40 241 44 with with IN cord-006608-mq4a4u40 241 45 hantavirus hantavirus NN cord-006608-mq4a4u40 241 46 pulmonary pulmonary JJ cord-006608-mq4a4u40 241 47 syndrome syndrome NN cord-006608-mq4a4u40 241 48 by by IN cord-006608-mq4a4u40 241 49 a a DT cord-006608-mq4a4u40 241 50 strip strip NN cord-006608-mq4a4u40 241 51 immunoblot immunoblot NNP cord-006608-mq4a4u40 241 52 assay assay NN cord-006608-mq4a4u40 241 53 suitable suitable JJ cord-006608-mq4a4u40 241 54 for for IN cord-006608-mq4a4u40 241 55 field field NN cord-006608-mq4a4u40 241 56 diagnosis diagnosis NN cord-006608-mq4a4u40 242 1 Sin sin NN cord-006608-mq4a4u40 242 2 Nombre Nombre NNP cord-006608-mq4a4u40 242 3 virus virus NN cord-006608-mq4a4u40 242 4 ( ( -LRB- cord-006608-mq4a4u40 242 5 SNV SNV NNP cord-006608-mq4a4u40 242 6 ) ) -RRB- cord-006608-mq4a4u40 243 1 Ig ig JJ cord-006608-mq4a4u40 243 2 isotype isotype NN cord-006608-mq4a4u40 243 3 antibody antibody NN cord-006608-mq4a4u40 243 4 response response NN cord-006608-mq4a4u40 243 5 during during IN cord-006608-mq4a4u40 243 6 acute acute JJ cord-006608-mq4a4u40 243 7 and and CC cord-006608-mq4a4u40 243 8 convalescent convalescent JJ cord-006608-mq4a4u40 243 9 phases phase NNS cord-006608-mq4a4u40 243 10 of of IN cord-006608-mq4a4u40 243 11 hantavirus hantavirus NN cord-006608-mq4a4u40 243 12 pulmonary pulmonary JJ cord-006608-mq4a4u40 243 13 syndrome syndrome NN cord-006608-mq4a4u40 243 14 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 243 15 pulmonary pulmonary JJ cord-006608-mq4a4u40 243 16 syndrome syndrome NN cord-006608-mq4a4u40 243 17 High high JJ cord-006608-mq4a4u40 243 18 levels level NNS cord-006608-mq4a4u40 243 19 of of IN cord-006608-mq4a4u40 243 20 cytokineproducing cytokineproduce VBG cord-006608-mq4a4u40 243 21 cells cell NNS cord-006608-mq4a4u40 243 22 in in IN cord-006608-mq4a4u40 243 23 the the DT cord-006608-mq4a4u40 243 24 lung lung NN cord-006608-mq4a4u40 243 25 tissues tissue NNS cord-006608-mq4a4u40 243 26 of of IN cord-006608-mq4a4u40 243 27 patients patient NNS cord-006608-mq4a4u40 243 28 with with IN cord-006608-mq4a4u40 243 29 fatal fatal JJ cord-006608-mq4a4u40 243 30 hantavirus hantavirus NN cord-006608-mq4a4u40 243 31 pulmonary pulmonary JJ cord-006608-mq4a4u40 243 32 syndrome syndrome NN cord-006608-mq4a4u40 243 33 B3 b3 NN cord-006608-mq4a4u40 243 34 integrins integrin NNS cord-006608-mq4a4u40 243 35 mediate mediate VBP cord-006608-mq4a4u40 243 36 the the DT cord-006608-mq4a4u40 243 37 cellular cellular JJ cord-006608-mq4a4u40 243 38 entry entry NN cord-006608-mq4a4u40 243 39 of of IN cord-006608-mq4a4u40 243 40 hantaviruses hantaviruse NNS cord-006608-mq4a4u40 243 41 that that WDT cord-006608-mq4a4u40 243 42 cause cause VBP cord-006608-mq4a4u40 243 43 respiratory respiratory JJ cord-006608-mq4a4u40 243 44 failure failure NN cord-006608-mq4a4u40 244 1 This this DT cord-006608-mq4a4u40 244 2 study study NN cord-006608-mq4a4u40 244 3 identifies identify VBZ cord-006608-mq4a4u40 244 4 the the DT cord-006608-mq4a4u40 244 5 β-3 β-3 NNP cord-006608-mq4a4u40 244 6 integrins integrin NNS cord-006608-mq4a4u40 244 7 as as IN cord-006608-mq4a4u40 244 8 the the DT cord-006608-mq4a4u40 244 9 cellular cellular JJ cord-006608-mq4a4u40 244 10 receptors receptor NNS cord-006608-mq4a4u40 244 11 for for IN cord-006608-mq4a4u40 244 12 hantaviruses hantaviruses NNP cord-006608-mq4a4u40 244 13 and and CC cord-006608-mq4a4u40 244 14 investigates investigate VBZ cord-006608-mq4a4u40 244 15 the the DT cord-006608-mq4a4u40 244 16 roles role NNS cord-006608-mq4a4u40 244 17 of of IN cord-006608-mq4a4u40 244 18 different different JJ cord-006608-mq4a4u40 244 19 integrins integrin NNS cord-006608-mq4a4u40 244 20 in in IN cord-006608-mq4a4u40 244 21 facilitating facilitate VBG cord-006608-mq4a4u40 244 22 the the DT cord-006608-mq4a4u40 244 23 entry entry NN cord-006608-mq4a4u40 244 24 of of IN cord-006608-mq4a4u40 244 25 pathogenic pathogenic JJ cord-006608-mq4a4u40 244 26 versus versus IN cord-006608-mq4a4u40 244 27 nonpathogenic nonpathogenic JJ cord-006608-mq4a4u40 244 28 strains strain NNS cord-006608-mq4a4u40 244 29 of of IN cord-006608-mq4a4u40 244 30 hantavirus hantavirus NN cord-006608-mq4a4u40 244 31 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 244 32 pulmonary pulmonary JJ cord-006608-mq4a4u40 244 33 syndrome syndrome NN cord-006608-mq4a4u40 244 34 : : : cord-006608-mq4a4u40 244 35 CD4 CD4 NNP cord-006608-mq4a4u40 244 36 and and CC cord-006608-mq4a4u40 244 37 CD8 CD8 NNP cord-006608-mq4a4u40 244 38 cytotoxic cytotoxic JJ cord-006608-mq4a4u40 244 39 T T NNP cord-006608-mq4a4u40 244 40 lymphocytes lymphocyte NNS cord-006608-mq4a4u40 244 41 to to IN cord-006608-mq4a4u40 244 42 epitopes epitope NNS cord-006608-mq4a4u40 244 43 on on IN cord-006608-mq4a4u40 244 44 Sin Sin NNP cord-006608-mq4a4u40 244 45 Nombre Nombre NNP cord-006608-mq4a4u40 244 46 Virus Virus NNP cord-006608-mq4a4u40 244 47 nucleocapsid nucleocapsid NN cord-006608-mq4a4u40 244 48 protein protein NN cord-006608-mq4a4u40 244 49 isolated isolate VBN cord-006608-mq4a4u40 244 50 during during IN cord-006608-mq4a4u40 244 51 acute acute JJ cord-006608-mq4a4u40 244 52 illness illness NN cord-006608-mq4a4u40 245 1 Humoral Humoral NNP cord-006608-mq4a4u40 245 2 immune immune JJ cord-006608-mq4a4u40 245 3 responses response NNS cord-006608-mq4a4u40 245 4 in in IN cord-006608-mq4a4u40 245 5 the the DT cord-006608-mq4a4u40 245 6 hantavirus hantavirus NN cord-006608-mq4a4u40 245 7 pulmonary pulmonary JJ cord-006608-mq4a4u40 245 8 syndrome syndrome NN cord-006608-mq4a4u40 246 1 Intravenous intravenous NN cord-006608-mq4a4u40 246 2 ribavirin ribavirin RB cord-006608-mq4a4u40 246 3 for for IN cord-006608-mq4a4u40 246 4 hantavirus hantavirus NN cord-006608-mq4a4u40 246 5 pulmonary pulmonary JJ cord-006608-mq4a4u40 246 6 syndrome syndrome NN cord-006608-mq4a4u40 246 7 : : : cord-006608-mq4a4u40 247 1 safety safety NN cord-006608-mq4a4u40 247 2 and and CC cord-006608-mq4a4u40 247 3 tolerance tolerance NN cord-006608-mq4a4u40 247 4 during during IN cord-006608-mq4a4u40 247 5 1 1 CD cord-006608-mq4a4u40 247 6 year year NN cord-006608-mq4a4u40 247 7 of of IN cord-006608-mq4a4u40 247 8 open open JJ cord-006608-mq4a4u40 247 9 - - HYPH cord-006608-mq4a4u40 247 10 label label NN cord-006608-mq4a4u40 247 11 experience experience NN cord-006608-mq4a4u40 247 12 Successful successful JJ cord-006608-mq4a4u40 247 13 treatment treatment NN cord-006608-mq4a4u40 247 14 of of IN cord-006608-mq4a4u40 247 15 adults adult NNS cord-006608-mq4a4u40 247 16 with with IN cord-006608-mq4a4u40 247 17 severe severe JJ cord-006608-mq4a4u40 247 18 hantavirus hantavirus NN cord-006608-mq4a4u40 247 19 pulmonary pulmonary JJ cord-006608-mq4a4u40 247 20 syndrome syndrome NN cord-006608-mq4a4u40 247 21 with with IN cord-006608-mq4a4u40 247 22 extracorporeal extracorporeal JJ cord-006608-mq4a4u40 247 23 membrane membrane NN cord-006608-mq4a4u40 247 24 oxygenation oxygenation NN cord-006608-mq4a4u40 248 1 This this DT cord-006608-mq4a4u40 248 2 is be VBZ cord-006608-mq4a4u40 248 3 a a DT cord-006608-mq4a4u40 248 4 review review NN cord-006608-mq4a4u40 248 5 of of IN cord-006608-mq4a4u40 248 6 the the DT cord-006608-mq4a4u40 248 7 use use NN cord-006608-mq4a4u40 248 8 of of IN cord-006608-mq4a4u40 248 9 ECMO ECMO NNP cord-006608-mq4a4u40 248 10 in in IN cord-006608-mq4a4u40 248 11 three three CD cord-006608-mq4a4u40 248 12 patients patient NNS cord-006608-mq4a4u40 248 13 with with IN cord-006608-mq4a4u40 248 14 HPS HPS NNP cord-006608-mq4a4u40 248 15 . . . cord-006608-mq4a4u40 249 1 It -PRON- PRP cord-006608-mq4a4u40 249 2 discusses discuss VBZ cord-006608-mq4a4u40 249 3 the the DT cord-006608-mq4a4u40 249 4 rationale rationale NN cord-006608-mq4a4u40 249 5 for for IN cord-006608-mq4a4u40 249 6 use use NN cord-006608-mq4a4u40 249 7 , , , cord-006608-mq4a4u40 249 8 inclusion inclusion NN cord-006608-mq4a4u40 249 9 criteria criterion NNS cord-006608-mq4a4u40 249 10 , , , cord-006608-mq4a4u40 249 11 clinical clinical JJ cord-006608-mq4a4u40 249 12 course course NN cord-006608-mq4a4u40 249 13 , , , cord-006608-mq4a4u40 249 14 and and CC cord-006608-mq4a4u40 249 15 outcome outcome VBD cord-006608-mq4a4u40 249 16 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 249 17 pulmonary pulmonary JJ cord-006608-mq4a4u40 249 18 syndrome syndrome NN cord-006608-mq4a4u40 249 19 treated treat VBN cord-006608-mq4a4u40 249 20 with with IN cord-006608-mq4a4u40 249 21 inhaled inhale VBN cord-006608-mq4a4u40 249 22 nitric nitric NN cord-006608-mq4a4u40 249 23 oxide oxide NN cord-006608-mq4a4u40 249 24 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 249 25 infection infection NN cord-006608-mq4a4u40 249 26 - - HYPH cord-006608-mq4a4u40 249 27 southwestern southwestern JJ cord-006608-mq4a4u40 249 28 United United NNP cord-006608-mq4a4u40 249 29 States States NNP cord-006608-mq4a4u40 249 30 . . . cord-006608-mq4a4u40 250 1 Interim interim JJ cord-006608-mq4a4u40 250 2 recommendations recommendation NNS cord-006608-mq4a4u40 250 3 for for IN cord-006608-mq4a4u40 250 4 risk risk NN cord-006608-mq4a4u40 250 5 reduction reduction NN cord-006608-mq4a4u40 250 6 Antibody Antibody NNP cord-006608-mq4a4u40 250 7 responses response NNS cord-006608-mq4a4u40 250 8 in in IN cord-006608-mq4a4u40 250 9 humans human NNS cord-006608-mq4a4u40 250 10 to to IN cord-006608-mq4a4u40 250 11 an an DT cord-006608-mq4a4u40 250 12 inactivated inactivate VBN cord-006608-mq4a4u40 250 13 hantavirus hantavirus NN cord-006608-mq4a4u40 250 14 vaccine vaccine NN cord-006608-mq4a4u40 250 15 A a DT cord-006608-mq4a4u40 250 16 Vaccinia vaccinia NN cord-006608-mq4a4u40 250 17 virusvectored virusvectore VBN cord-006608-mq4a4u40 250 18 Hantaan Hantaan NNP cord-006608-mq4a4u40 250 19 virus virus NN cord-006608-mq4a4u40 250 20 vaccine vaccine NN cord-006608-mq4a4u40 250 21 protects protect VBZ cord-006608-mq4a4u40 250 22 hamsters hamster NNS cord-006608-mq4a4u40 250 23 from from IN cord-006608-mq4a4u40 250 24 challenge challenge NN cord-006608-mq4a4u40 250 25 with with IN cord-006608-mq4a4u40 250 26 Hantaan Hantaan NNP cord-006608-mq4a4u40 250 27 and and CC cord-006608-mq4a4u40 250 28 Seoul Seoul NNP cord-006608-mq4a4u40 250 29 viruses virus NNS cord-006608-mq4a4u40 250 30 but but CC cord-006608-mq4a4u40 251 1 not not RB cord-006608-mq4a4u40 251 2 Pumaala Pumaala NNP cord-006608-mq4a4u40 251 3 virus virus NN cord-006608-mq4a4u40 251 4 Antigenic antigenic JJ cord-006608-mq4a4u40 251 5 subunits subunit NNS cord-006608-mq4a4u40 251 6 of of IN cord-006608-mq4a4u40 251 7 Hantaan Hantaan NNP cord-006608-mq4a4u40 251 8 virus virus NN cord-006608-mq4a4u40 251 9 expressed express VBN cord-006608-mq4a4u40 251 10 by by IN cord-006608-mq4a4u40 251 11 baculovirus baculovirus NNP cord-006608-mq4a4u40 251 12 and and CC cord-006608-mq4a4u40 251 13 vaccinia vaccinia NN cord-006608-mq4a4u40 251 14 virus virus NN cord-006608-mq4a4u40 251 15 recombinants recombinant VBZ cord-006608-mq4a4u40 251 16 Immunity immunity NN cord-006608-mq4a4u40 251 17 to to IN cord-006608-mq4a4u40 251 18 Hantavirus Hantavirus NNP cord-006608-mq4a4u40 251 19 challenge challenge NN cord-006608-mq4a4u40 251 20 in in IN cord-006608-mq4a4u40 251 21 Meriones Meriones NNP cord-006608-mq4a4u40 251 22 unguicalatus unguicalatus NN cord-006608-mq4a4u40 251 23 induced induce VBN cord-006608-mq4a4u40 251 24 by by IN cord-006608-mq4a4u40 251 25 vacciniavectored vacciniavectored JJ cord-006608-mq4a4u40 251 26 viral viral JJ cord-006608-mq4a4u40 251 27 proteins protein NNS cord-006608-mq4a4u40 251 28 DNA DNA NNP cord-006608-mq4a4u40 251 29 vaccination vaccination NN cord-006608-mq4a4u40 251 30 with with IN cord-006608-mq4a4u40 251 31 hantavirus hantavirus NN cord-006608-mq4a4u40 251 32 M M NNP cord-006608-mq4a4u40 251 33 segment segment NN cord-006608-mq4a4u40 251 34 elicits elicit VBZ cord-006608-mq4a4u40 251 35 neutralizing neutralize VBG cord-006608-mq4a4u40 251 36 antibodies antibody NNS cord-006608-mq4a4u40 251 37 and and CC cord-006608-mq4a4u40 251 38 protects protect VBZ cord-006608-mq4a4u40 251 39 against against IN cord-006608-mq4a4u40 251 40 Seoul Seoul NNP cord-006608-mq4a4u40 251 41 virus virus NN cord-006608-mq4a4u40 251 42 infection infection NN cord-006608-mq4a4u40 251 43 Update update NN cord-006608-mq4a4u40 251 44 : : : cord-006608-mq4a4u40 251 45 hantavirus hantavirus NN cord-006608-mq4a4u40 251 46 pulmonary pulmonary JJ cord-006608-mq4a4u40 251 47 syndrome syndrome NN cord-006608-mq4a4u40 251 48 -United -unite VBD cord-006608-mq4a4u40 251 49 States States NNP