id	sid	tid	token	lemma	pos
cord-019001-ralxw4ad	1	1	key	key	JJ
cord-019001-ralxw4ad	1	2	:	:	:
cord-019001-ralxw4ad	1	3	cord-019001-ralxw4ad	cord-019001-ralxw4ad	ADD
cord-019001-ralxw4ad	1	4	authors	author	NNS
cord-019001-ralxw4ad	1	5	:	:	:
cord-019001-ralxw4ad	1	6	Oishi	Oishi	NNP
cord-019001-ralxw4ad	1	7	,	,	,
cord-019001-ralxw4ad	1	8	Peter	Peter	NNP
cord-019001-ralxw4ad	1	9	;	;	:
cord-019001-ralxw4ad	1	10	Fineman	Fineman	NNP
cord-019001-ralxw4ad	1	11	,	,	,
cord-019001-ralxw4ad	1	12	Jeffrey	Jeffrey	NNP
cord-019001-ralxw4ad	1	13	R.	R.	NNP
cord-019001-ralxw4ad	1	14	title	title	NN
cord-019001-ralxw4ad	1	15	:	:	:
cord-019001-ralxw4ad	1	16	Diseases	disease	NNS
cord-019001-ralxw4ad	1	17	of	of	IN
cord-019001-ralxw4ad	1	18	the	the	DT
cord-019001-ralxw4ad	1	19	Pulmonary	Pulmonary	NNP
cord-019001-ralxw4ad	1	20	Vascular	Vascular	NNP
cord-019001-ralxw4ad	1	21	System	System	NNP
cord-019001-ralxw4ad	1	22	date	date	NN
cord-019001-ralxw4ad	1	23	:	:	:
cord-019001-ralxw4ad	1	24	2008	2008	CD
cord-019001-ralxw4ad	1	25	-	-	SYM
cord-019001-ralxw4ad	1	26	11	11	CD
cord-019001-ralxw4ad	1	27	-	-	SYM
cord-019001-ralxw4ad	1	28	15	15	CD
cord-019001-ralxw4ad	1	29	journal	journal	NN
cord-019001-ralxw4ad	1	30	:	:	:
cord-019001-ralxw4ad	1	31	The	the	DT
cord-019001-ralxw4ad	1	32	Respiratory	respiratory	JJ
cord-019001-ralxw4ad	1	33	Tract	tract	NN
cord-019001-ralxw4ad	1	34	in	in	IN
cord-019001-ralxw4ad	1	35	Pediatric	Pediatric	NNP
cord-019001-ralxw4ad	1	36	Critical	Critical	NNP
cord-019001-ralxw4ad	1	37	Illness	Illness	NNP
cord-019001-ralxw4ad	1	38	and	and	CC
cord-019001-ralxw4ad	1	39	Injury	injury	NN
cord-019001-ralxw4ad	1	40	DOI	doi	NN
cord-019001-ralxw4ad	1	41	:	:	:
cord-019001-ralxw4ad	2	1	10.1007/978	10.1007/978	LS
cord-019001-ralxw4ad	2	2	-	-	HYPH
cord-019001-ralxw4ad	2	3	1	1	CD
cord-019001-ralxw4ad	2	4	-	-	HYPH
cord-019001-ralxw4ad	2	5	84800	84800	CD
cord-019001-ralxw4ad	2	6	-	-	HYPH
cord-019001-ralxw4ad	2	7	925	925	CD
cord-019001-ralxw4ad	2	8	-	-	HYPH
cord-019001-ralxw4ad	2	9	7_20	7_20	CD
cord-019001-ralxw4ad	2	10	sha	sha	NNP
cord-019001-ralxw4ad	2	11	:	:	:
cord-019001-ralxw4ad	3	1	ea92b30e2cdfa622b49d9fdcb84c5528ce8ed658	ea92b30e2cdfa622b49d9fdcb84c5528ce8ed658	NNS
cord-019001-ralxw4ad	3	2	doc_id	doc_id	CD
cord-019001-ralxw4ad	3	3	:	:	:
cord-019001-ralxw4ad	4	1	19001	19001	CD
cord-019001-ralxw4ad	4	2	cord_uid	cord_uid	NNS
cord-019001-ralxw4ad	4	3	:	:	:
cord-019001-ralxw4ad	5	1	ralxw4ad	ralxw4ad	NNP
cord-019001-ralxw4ad	5	2	nan	nan	NNP
cord-019001-ralxw4ad	6	1	Although	although	IN
cord-019001-ralxw4ad	6	2	historically	historically	RB
cord-019001-ralxw4ad	6	3	considered	consider	VBD
cord-019001-ralxw4ad	6	4	the	the	DT
cord-019001-ralxw4ad	6	5	lesser	less	JJR
cord-019001-ralxw4ad	6	6	circulation	circulation	NN
cord-019001-ralxw4ad	6	7	,	,	,
cord-019001-ralxw4ad	6	8	pathology	pathology	NN
cord-019001-ralxw4ad	6	9	of	of	IN
cord-019001-ralxw4ad	6	10	the	the	DT
cord-019001-ralxw4ad	6	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	6	12	circulation	circulation	NN
cord-019001-ralxw4ad	6	13	is	be	VBZ
cord-019001-ralxw4ad	6	14	a	a	DT
cord-019001-ralxw4ad	6	15	great	great	JJ
cord-019001-ralxw4ad	6	16	source	source	NN
cord-019001-ralxw4ad	6	17	of	of	IN
cord-019001-ralxw4ad	6	18	pediatric	pediatric	JJ
cord-019001-ralxw4ad	6	19	morbidity	morbidity	NN
cord-019001-ralxw4ad	6	20	and	and	CC
cord-019001-ralxw4ad	6	21	mortality	mortality	NN
cord-019001-ralxw4ad	6	22	.	.	.
cord-019001-ralxw4ad	7	1	This	this	DT
cord-019001-ralxw4ad	7	2	is	be	VBZ
cord-019001-ralxw4ad	7	3	most	most	RBS
cord-019001-ralxw4ad	7	4	commonly	commonly	RB
cord-019001-ralxw4ad	7	5	displayed	display	VBN
cord-019001-ralxw4ad	7	6	in	in	IN
cord-019001-ralxw4ad	7	7	neonates	neonate	NNS
cord-019001-ralxw4ad	7	8	with	with	IN
cord-019001-ralxw4ad	7	9	persistent	persistent	JJ
cord-019001-ralxw4ad	7	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	7	11	hypertension	hypertension	NN
cord-019001-ralxw4ad	7	12	;	;	:
cord-019001-ralxw4ad	7	13	neonates	neonate	NNS
cord-019001-ralxw4ad	7	14	,	,	,
cord-019001-ralxw4ad	7	15	infants	infant	NNS
cord-019001-ralxw4ad	7	16	,	,	,
cord-019001-ralxw4ad	7	17	and	and	CC
cord-019001-ralxw4ad	7	18	children	child	NNS
cord-019001-ralxw4ad	7	19	with	with	IN
cord-019001-ralxw4ad	7	20	congenital	congenital	JJ
cord-019001-ralxw4ad	7	21	heart	heart	NN
cord-019001-ralxw4ad	7	22	disease	disease	NN
cord-019001-ralxw4ad	7	23	;	;	:
cord-019001-ralxw4ad	7	24	and	and	CC
cord-019001-ralxw4ad	7	25	adolescents	adolescent	NNS
cord-019001-ralxw4ad	7	26	and	and	CC
cord-019001-ralxw4ad	7	27	young	young	JJ
cord-019001-ralxw4ad	7	28	adults	adult	NNS
cord-019001-ralxw4ad	7	29	with	with	IN
cord-019001-ralxw4ad	7	30	primary	primary	JJ
cord-019001-ralxw4ad	7	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	7	32	hypertension	hypertension	NN
cord-019001-ralxw4ad	7	33	.	.	.
cord-019001-ralxw4ad	8	1	Recent	recent	JJ
cord-019001-ralxw4ad	8	2	evidence	evidence	NN
cord-019001-ralxw4ad	8	3	indicates	indicate	VBZ
cord-019001-ralxw4ad	8	4	that	that	IN
cord-019001-ralxw4ad	8	5	normal	normal	JJ
cord-019001-ralxw4ad	8	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	8	7	vascular	vascular	JJ
cord-019001-ralxw4ad	8	8	tone	tone	NN
cord-019001-ralxw4ad	8	9	is	be	VBZ
cord-019001-ralxw4ad	8	10	regulated	regulate	VBN
cord-019001-ralxw4ad	8	11	by	by	IN
cord-019001-ralxw4ad	8	12	a	a	DT
cord-019001-ralxw4ad	8	13	complex	complex	JJ
cord-019001-ralxw4ad	8	14	interaction	interaction	NN
cord-019001-ralxw4ad	8	15	of	of	IN
cord-019001-ralxw4ad	8	16	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	8	17	substances	substance	NNS
cord-019001-ralxw4ad	8	18	that	that	WDT
cord-019001-ralxw4ad	8	19	are	be	VBP
cord-019001-ralxw4ad	8	20	locally	locally	RB
cord-019001-ralxw4ad	8	21	produced	produce	VBN
cord-019001-ralxw4ad	8	22	by	by	IN
cord-019001-ralxw4ad	8	23	the	the	DT
cord-019001-ralxw4ad	8	24	vascular	vascular	JJ
cord-019001-ralxw4ad	8	25	endothelium	endothelium	NN
cord-019001-ralxw4ad	8	26	[	[	-LRB-
cord-019001-ralxw4ad	8	27	1	1	CD
cord-019001-ralxw4ad	8	28	]	]	-RRB-
cord-019001-ralxw4ad	8	29	[	[	-LRB-
cord-019001-ralxw4ad	8	30	2	2	CD
cord-019001-ralxw4ad	8	31	]	]	-RRB-
cord-019001-ralxw4ad	8	32	[	[	-LRB-
cord-019001-ralxw4ad	8	33	3	3	CD
cord-019001-ralxw4ad	8	34	]	]	-RRB-
cord-019001-ralxw4ad	8	35	[	[	-LRB-
cord-019001-ralxw4ad	8	36	4	4	CD
cord-019001-ralxw4ad	8	37	]	]	-RRB-
cord-019001-ralxw4ad	8	38	[	[	-LRB-
cord-019001-ralxw4ad	8	39	5	5	CD
cord-019001-ralxw4ad	8	40	]	]	-RRB-
cord-019001-ralxw4ad	8	41	[	[	-LRB-
cord-019001-ralxw4ad	8	42	6	6	CD
cord-019001-ralxw4ad	8	43	]	]	-RRB-
cord-019001-ralxw4ad	8	44	.	.	.
cord-019001-ralxw4ad	9	1	These	these	DT
cord-019001-ralxw4ad	9	2	substances	substance	NNS
cord-019001-ralxw4ad	9	3	,	,	,
cord-019001-ralxw4ad	9	4	such	such	JJ
cord-019001-ralxw4ad	9	5	as	as	IN
cord-019001-ralxw4ad	9	6	nitric	nitric	JJ
cord-019001-ralxw4ad	9	7	oxide	oxide	NN
cord-019001-ralxw4ad	9	8	(	(	-LRB-
cord-019001-ralxw4ad	9	9	NO	no	UH
cord-019001-ralxw4ad	9	10	)	)	-RRB-
cord-019001-ralxw4ad	9	11	and	and	CC
cord-019001-ralxw4ad	9	12	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	9	13	(	(	-LRB-
cord-019001-ralxw4ad	9	14	ET-1	ET-1	NNP
cord-019001-ralxw4ad	9	15	)	)	-RRB-
cord-019001-ralxw4ad	9	16	,	,	,
cord-019001-ralxw4ad	9	17	are	be	VBP
cord-019001-ralxw4ad	9	18	capable	capable	JJ
cord-019001-ralxw4ad	9	19	of	of	IN
cord-019001-ralxw4ad	9	20	producing	produce	VBG
cord-019001-ralxw4ad	9	21	vascular	vascular	JJ
cord-019001-ralxw4ad	9	22	relaxation	relaxation	NN
cord-019001-ralxw4ad	9	23	and/or	and/or	CC
cord-019001-ralxw4ad	9	24	constriction	constriction	NN
cord-019001-ralxw4ad	9	25	,	,	,
cord-019001-ralxw4ad	9	26	modulating	modulate	VBG
cord-019001-ralxw4ad	9	27	the	the	DT
cord-019001-ralxw4ad	9	28	propensity	propensity	NN
cord-019001-ralxw4ad	9	29	of	of	IN
cord-019001-ralxw4ad	9	30	blood	blood	NN
cord-019001-ralxw4ad	9	31	to	to	IN
cord-019001-ralxw4ad	9	32	clot	clot	NN
cord-019001-ralxw4ad	9	33	,	,	,
cord-019001-ralxw4ad	9	34	and	and	CC
cord-019001-ralxw4ad	9	35	inducing	induce	VBG
cord-019001-ralxw4ad	9	36	and/or	and/or	CC
cord-019001-ralxw4ad	9	37	inhibiting	inhibit	VBG
cord-019001-ralxw4ad	9	38	smooth	smooth	JJ
cord-019001-ralxw4ad	9	39	muscle	muscle	NN
cord-019001-ralxw4ad	9	40	cell	cell	NN
cord-019001-ralxw4ad	9	41	migration	migration	NN
cord-019001-ralxw4ad	9	42	and	and	CC
cord-019001-ralxw4ad	9	43	replication	replication	NN
cord-019001-ralxw4ad	9	44	[	[	-LRB-
cord-019001-ralxw4ad	9	45	6	6	CD
cord-019001-ralxw4ad	9	46	]	]	-RRB-
cord-019001-ralxw4ad	9	47	[	[	-LRB-
cord-019001-ralxw4ad	9	48	7	7	CD
cord-019001-ralxw4ad	9	49	]	]	-RRB-
cord-019001-ralxw4ad	9	50	[	[	-LRB-
cord-019001-ralxw4ad	9	51	8	8	CD
cord-019001-ralxw4ad	9	52	]	]	-RRB-
cord-019001-ralxw4ad	9	53	[	[	-LRB-
cord-019001-ralxw4ad	9	54	9	9	CD
cord-019001-ralxw4ad	9	55	]	]	-RRB-
cord-019001-ralxw4ad	9	56	[	[	-LRB-
cord-019001-ralxw4ad	9	57	10	10	CD
cord-019001-ralxw4ad	9	58	]	]	-RRB-
cord-019001-ralxw4ad	9	59	[	[	-LRB-
cord-019001-ralxw4ad	9	60	11	11	CD
cord-019001-ralxw4ad	9	61	]	]	-RRB-
cord-019001-ralxw4ad	9	62	[	[	-LRB-
cord-019001-ralxw4ad	9	63	12	12	CD
cord-019001-ralxw4ad	9	64	]	]	-RRB-
cord-019001-ralxw4ad	9	65	[	[	-LRB-
cord-019001-ralxw4ad	9	66	13	13	CD
cord-019001-ralxw4ad	9	67	]	]	-RRB-
cord-019001-ralxw4ad	9	68	[	[	-LRB-
cord-019001-ralxw4ad	9	69	14	14	CD
cord-019001-ralxw4ad	9	70	]	]	-RRB-
cord-019001-ralxw4ad	9	71	[	[	-LRB-
cord-019001-ralxw4ad	9	72	15	15	CD
cord-019001-ralxw4ad	9	73	]	]	-RRB-
cord-019001-ralxw4ad	9	74	[	[	-LRB-
cord-019001-ralxw4ad	9	75	16	16	CD
cord-019001-ralxw4ad	9	76	]	]	-RRB-
cord-019001-ralxw4ad	9	77	[	[	-LRB-
cord-019001-ralxw4ad	9	78	17	17	CD
cord-019001-ralxw4ad	9	79	]	]	-RRB-
cord-019001-ralxw4ad	9	80	[	[	-LRB-
cord-019001-ralxw4ad	9	81	18	18	CD
cord-019001-ralxw4ad	9	82	]	]	-RRB-
cord-019001-ralxw4ad	9	83	[	[	-LRB-
cord-019001-ralxw4ad	9	84	19	19	CD
cord-019001-ralxw4ad	9	85	]	]	-RRB-
cord-019001-ralxw4ad	9	86	[	[	-LRB-
cord-019001-ralxw4ad	9	87	20	20	CD
cord-019001-ralxw4ad	9	88	]	]	-RRB-
cord-019001-ralxw4ad	9	89	.	.	.
cord-019001-ralxw4ad	10	1	In	in	IN
cord-019001-ralxw4ad	10	2	fact	fact	NN
cord-019001-ralxw4ad	10	3	,	,	,
cord-019001-ralxw4ad	10	4	mounting	mount	VBG
cord-019001-ralxw4ad	10	5	data	datum	NNS
cord-019001-ralxw4ad	10	6	implicate	implicate	VBP
cord-019001-ralxw4ad	10	7	endothelial	endothelial	JJ
cord-019001-ralxw4ad	10	8	injury	injury	NN
cord-019001-ralxw4ad	10	9	and	and	CC
cord-019001-ralxw4ad	10	10	the	the	DT
cord-019001-ralxw4ad	10	11	subsequent	subsequent	JJ
cord-019001-ralxw4ad	10	12	aberration	aberration	NN
cord-019001-ralxw4ad	10	13	in	in	IN
cord-019001-ralxw4ad	10	14	the	the	DT
cord-019001-ralxw4ad	10	15	endogenous	endogenous	JJ
cord-019001-ralxw4ad	10	16	production	production	NN
cord-019001-ralxw4ad	10	17	of	of	IN
cord-019001-ralxw4ad	10	18	these	these	DT
cord-019001-ralxw4ad	10	19	substances	substance	NNS
cord-019001-ralxw4ad	10	20	in	in	IN
cord-019001-ralxw4ad	10	21	the	the	DT
cord-019001-ralxw4ad	10	22	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	10	23	of	of	IN
cord-019001-ralxw4ad	10	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	10	25	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	10	26	disorders	disorder	NNS
cord-019001-ralxw4ad	10	27	[	[	-LRB-
cord-019001-ralxw4ad	10	28	21	21	CD
cord-019001-ralxw4ad	10	29	]	]	-RRB-
cord-019001-ralxw4ad	11	1	[	[	-LRB-
cord-019001-ralxw4ad	11	2	22	22	CD
cord-019001-ralxw4ad	11	3	]	]	-RRB-
cord-019001-ralxw4ad	11	4	[	[	-LRB-
cord-019001-ralxw4ad	11	5	23	23	CD
cord-019001-ralxw4ad	11	6	]	]	-RRB-
cord-019001-ralxw4ad	12	1	[	[	-LRB-
cord-019001-ralxw4ad	12	2	24	24	CD
cord-019001-ralxw4ad	12	3	]	]	-RRB-
cord-019001-ralxw4ad	12	4	[	[	-LRB-
cord-019001-ralxw4ad	12	5	25	25	CD
cord-019001-ralxw4ad	12	6	]	]	-RRB-
cord-019001-ralxw4ad	12	7	.	.	.
cord-019001-ralxw4ad	13	1	This	this	DT
cord-019001-ralxw4ad	13	2	chapter	chapter	NN
cord-019001-ralxw4ad	13	3	discusses	discuss	VBZ
cord-019001-ralxw4ad	13	4	the	the	DT
cord-019001-ralxw4ad	13	5	normal	normal	JJ
cord-019001-ralxw4ad	13	6	regulation	regulation	NN
cord-019001-ralxw4ad	13	7	of	of	IN
cord-019001-ralxw4ad	13	8	the	the	DT
cord-019001-ralxw4ad	13	9	fetal	fetal	JJ
cord-019001-ralxw4ad	13	10	,	,	,
cord-019001-ralxw4ad	13	11	transitional	transitional	JJ
cord-019001-ralxw4ad	13	12	,	,	,
cord-019001-ralxw4ad	13	13	and	and	CC
cord-019001-ralxw4ad	13	14	postnatal	postnatal	JJ
cord-019001-ralxw4ad	13	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	13	16	circulations	circulation	NNS
cord-019001-ralxw4ad	13	17	,	,	,
cord-019001-ralxw4ad	13	18	the	the	DT
cord-019001-ralxw4ad	13	19	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	13	20	of	of	IN
cord-019001-ralxw4ad	13	21	pediatric	pediatric	JJ
cord-019001-ralxw4ad	13	22	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	13	23	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	13	24	disorders	disorder	NNS
cord-019001-ralxw4ad	13	25	,	,	,
cord-019001-ralxw4ad	13	26	and	and	CC
cord-019001-ralxw4ad	13	27	new	new	JJ
cord-019001-ralxw4ad	13	28	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	13	29	and	and	CC
cord-019001-ralxw4ad	13	30	preventative	preventative	JJ
cord-019001-ralxw4ad	13	31	strategies	strategy	NNS
cord-019001-ralxw4ad	13	32	for	for	IN
cord-019001-ralxw4ad	13	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	13	34	hypertension	hypertension	NN
cord-019001-ralxw4ad	13	35	.	.	.
cord-019001-ralxw4ad	14	1	Particular	particular	JJ
cord-019001-ralxw4ad	14	2	emphasis	emphasis	NN
cord-019001-ralxw4ad	14	3	is	be	VBZ
cord-019001-ralxw4ad	14	4	placed	place	VBN
cord-019001-ralxw4ad	14	5	on	on	IN
cord-019001-ralxw4ad	14	6	the	the	DT
cord-019001-ralxw4ad	14	7	role	role	NN
cord-019001-ralxw4ad	14	8	of	of	IN
cord-019001-ralxw4ad	14	9	the	the	DT
cord-019001-ralxw4ad	14	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	14	11	vascular	vascular	JJ
cord-019001-ralxw4ad	14	12	endothelium	endothelium	NN
cord-019001-ralxw4ad	14	13	in	in	IN
cord-019001-ralxw4ad	14	14	these	these	DT
cord-019001-ralxw4ad	14	15	processes	process	NNS
cord-019001-ralxw4ad	14	16	and	and	CC
cord-019001-ralxw4ad	14	17	treatment	treatment	NN
cord-019001-ralxw4ad	14	18	modalities	modality	NNS
cord-019001-ralxw4ad	14	19	.	.	.
cord-019001-ralxw4ad	15	1	fl	fl	NNP
cord-019001-ralxw4ad	15	2	ow	ow	UH
cord-019001-ralxw4ad	15	3	and	and	CC
cord-019001-ralxw4ad	15	4	decreases	decrease	VBZ
cord-019001-ralxw4ad	15	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	15	6	vascular	vascular	JJ
cord-019001-ralxw4ad	15	7	resistance	resistance	NN
cord-019001-ralxw4ad	15	8	but	but	CC
cord-019001-ralxw4ad	15	9	not	not	RB
cord-019001-ralxw4ad	15	10	to	to	IN
cord-019001-ralxw4ad	15	11	newborn	newborn	JJ
cord-019001-ralxw4ad	15	12	values	value	NNS
cord-019001-ralxw4ad	15	13	[	[	-LRB-
cord-019001-ralxw4ad	15	14	33	33	CD
cord-019001-ralxw4ad	15	15	]	]	-RRB-
cord-019001-ralxw4ad	15	16	.	.	.
cord-019001-ralxw4ad	16	1	A	a	DT
cord-019001-ralxw4ad	16	2	proportion	proportion	NN
cord-019001-ralxw4ad	16	3	of	of	IN
cord-019001-ralxw4ad	16	4	this	this	DT
cord-019001-ralxw4ad	16	5	decrease	decrease	NN
cord-019001-ralxw4ad	16	6	relates	relate	VBZ
cord-019001-ralxw4ad	16	7	to	to	IN
cord-019001-ralxw4ad	16	8	alterations	alteration	NNS
cord-019001-ralxw4ad	16	9	in	in	IN
cord-019001-ralxw4ad	16	10	the	the	DT
cord-019001-ralxw4ad	16	11	physical	physical	JJ
cord-019001-ralxw4ad	16	12	architecture	architecture	NN
cord-019001-ralxw4ad	16	13	of	of	IN
cord-019001-ralxw4ad	16	14	the	the	DT
cord-019001-ralxw4ad	16	15	alveoli	alveolus	NNS
cord-019001-ralxw4ad	16	16	and	and	CC
cord-019001-ralxw4ad	16	17	small	small	JJ
cord-019001-ralxw4ad	16	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	16	19	vessels	vessel	NNS
cord-019001-ralxw4ad	16	20	that	that	WDT
cord-019001-ralxw4ad	16	21	occur	occur	VBP
cord-019001-ralxw4ad	16	22	with	with	IN
cord-019001-ralxw4ad	16	23	mechanical	mechanical	JJ
cord-019001-ralxw4ad	16	24	distention	distention	NN
cord-019001-ralxw4ad	16	25	[	[	-LRB-
cord-019001-ralxw4ad	16	26	34	34	CD
cord-019001-ralxw4ad	16	27	]	]	-RRB-
cord-019001-ralxw4ad	16	28	.	.	.
cord-019001-ralxw4ad	17	1	In	in	IN
cord-019001-ralxw4ad	17	2	addition	addition	NN
cord-019001-ralxw4ad	17	3	,	,	,
cord-019001-ralxw4ad	17	4	physical	physical	JJ
cord-019001-ralxw4ad	17	5	expansion	expansion	NN
cord-019001-ralxw4ad	17	6	of	of	IN
cord-019001-ralxw4ad	17	7	the	the	DT
cord-019001-ralxw4ad	17	8	lung	lung	NN
cord-019001-ralxw4ad	17	9	results	result	NNS
cord-019001-ralxw4ad	17	10	in	in	IN
cord-019001-ralxw4ad	17	11	the	the	DT
cord-019001-ralxw4ad	17	12	release	release	NN
cord-019001-ralxw4ad	17	13	of	of	IN
cord-019001-ralxw4ad	17	14	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	17	15	substances	substance	NNS
cord-019001-ralxw4ad	17	16	,	,	,
cord-019001-ralxw4ad	17	17	such	such	JJ
cord-019001-ralxw4ad	17	18	as	as	IN
cord-019001-ralxw4ad	17	19	PGI	PGI	NNP
cord-019001-ralxw4ad	17	20	2	2	CD
cord-019001-ralxw4ad	17	21	,	,	,
cord-019001-ralxw4ad	17	22	which	which	WDT
cord-019001-ralxw4ad	17	23	increases	increase	VBZ
cord-019001-ralxw4ad	17	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	17	25	blood	blood	NN
cord-019001-ralxw4ad	17	26	fl	fl	NNP
cord-019001-ralxw4ad	17	27	ow	ow	NN
cord-019001-ralxw4ad	17	28	and	and	CC
cord-019001-ralxw4ad	17	29	decreases	decrease	VBZ
cord-019001-ralxw4ad	17	30	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	17	31	vascular	vascular	JJ
cord-019001-ralxw4ad	17	32	resistance	resistance	NN
cord-019001-ralxw4ad	17	33	in	in	IN
cord-019001-ralxw4ad	17	34	the	the	DT
cord-019001-ralxw4ad	17	35	fetal	fetal	JJ
cord-019001-ralxw4ad	17	36	goat	goat	NN
cord-019001-ralxw4ad	17	37	and	and	CC
cord-019001-ralxw4ad	17	38	lamb	lamb	NNP
cord-019001-ralxw4ad	17	39	independent	independent	JJ
cord-019001-ralxw4ad	17	40	of	of	IN
cord-019001-ralxw4ad	17	41	the	the	DT
cord-019001-ralxw4ad	17	42	changes	change	NNS
cord-019001-ralxw4ad	17	43	in	in	IN
cord-019001-ralxw4ad	17	44	oxygen	oxygen	NN
cord-019001-ralxw4ad	17	45	tension	tension	NN
cord-019001-ralxw4ad	17	46	[	[	-LRB-
cord-019001-ralxw4ad	17	47	35	35	CD
cord-019001-ralxw4ad	17	48	]	]	-RRB-
cord-019001-ralxw4ad	17	49	[	[	-LRB-
cord-019001-ralxw4ad	17	50	36	36	CD
cord-019001-ralxw4ad	17	51	]	]	-RRB-
cord-019001-ralxw4ad	17	52	[	[	-LRB-
cord-019001-ralxw4ad	17	53	37	37	CD
cord-019001-ralxw4ad	17	54	]	]	-RRB-
cord-019001-ralxw4ad	17	55	[	[	-LRB-
cord-019001-ralxw4ad	17	56	38	38	CD
cord-019001-ralxw4ad	17	57	]	]	-RRB-
cord-019001-ralxw4ad	17	58	[	[	-LRB-
cord-019001-ralxw4ad	17	59	39	39	CD
cord-019001-ralxw4ad	17	60	]	]	-RRB-
cord-019001-ralxw4ad	17	61	[	[	-LRB-
cord-019001-ralxw4ad	17	62	40	40	CD
cord-019001-ralxw4ad	17	63	]	]	-RRB-
cord-019001-ralxw4ad	17	64	.	.	.
cord-019001-ralxw4ad	18	1	When	when	WRB
cord-019001-ralxw4ad	18	2	ventilation	ventilation	NN
cord-019001-ralxw4ad	18	3	is	be	VBZ
cord-019001-ralxw4ad	18	4	accompanied	accompany	VBN
cord-019001-ralxw4ad	18	5	by	by	IN
cord-019001-ralxw4ad	18	6	changes	change	NNS
cord-019001-ralxw4ad	18	7	in	in	IN
cord-019001-ralxw4ad	18	8	oxygen	oxygen	NN
cord-019001-ralxw4ad	18	9	tension	tension	NN
cord-019001-ralxw4ad	18	10	(	(	-LRB-
cord-019001-ralxw4ad	18	11	i.e.	i.e.	FW
cord-019001-ralxw4ad	18	12	,	,	,
cord-019001-ralxw4ad	18	13	ventilation	ventilation	NN
cord-019001-ralxw4ad	18	14	with	with	IN
cord-019001-ralxw4ad	18	15	ambient	ambient	JJ
cord-019001-ralxw4ad	18	16	air	air	NN
cord-019001-ralxw4ad	18	17	or	or	CC
cord-019001-ralxw4ad	18	18	supplemental	supplemental	JJ
cord-019001-ralxw4ad	18	19	oxygen	oxygen	NN
cord-019001-ralxw4ad	18	20	)	)	-RRB-
cord-019001-ralxw4ad	18	21	,	,	,
cord-019001-ralxw4ad	18	22	fetal	fetal	JJ
cord-019001-ralxw4ad	18	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	18	24	blood	blood	NN
cord-019001-ralxw4ad	18	25	fl	fl	NNP
cord-019001-ralxw4ad	18	26	ow	ow	NN
cord-019001-ralxw4ad	18	27	increases	increase	NNS
cord-019001-ralxw4ad	18	28	and	and	CC
cord-019001-ralxw4ad	18	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	18	30	vascular	vascular	JJ
cord-019001-ralxw4ad	18	31	resistance	resistance	NN
cord-019001-ralxw4ad	18	32	falls	fall	VBZ
cord-019001-ralxw4ad	18	33	to	to	IN
cord-019001-ralxw4ad	18	34	newborn	newborn	JJ
cord-019001-ralxw4ad	18	35	values	value	NNS
cord-019001-ralxw4ad	18	36	.	.	.
cord-019001-ralxw4ad	19	1	The	the	DT
cord-019001-ralxw4ad	19	2	exact	exact	JJ
cord-019001-ralxw4ad	19	3	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	19	4	of	of	IN
cord-019001-ralxw4ad	19	5	this	this	DT
cord-019001-ralxw4ad	19	6	oxygen	oxygen	NN
cord-019001-ralxw4ad	19	7	-	-	HYPH
cord-019001-ralxw4ad	19	8	induced	induce	VBN
cord-019001-ralxw4ad	19	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	19	10	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	19	11	remain	remain	VBP
cord-019001-ralxw4ad	19	12	unclear	unclear	JJ
cord-019001-ralxw4ad	19	13	.	.	.
cord-019001-ralxw4ad	20	1	Alveolar	alveolar	NN
cord-019001-ralxw4ad	20	2	and/or	and/or	CC
cord-019001-ralxw4ad	20	3	arterial	arterial	JJ
cord-019001-ralxw4ad	20	4	oxygen	oxygen	NN
cord-019001-ralxw4ad	20	5	may	may	MD
cord-019001-ralxw4ad	20	6	directly	directly	RB
cord-019001-ralxw4ad	20	7	dilate	dilate	VB
cord-019001-ralxw4ad	20	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	20	9	resistance	resistance	NN
cord-019001-ralxw4ad	20	10	vessels	vessel	NNS
cord-019001-ralxw4ad	20	11	or	or	CC
cord-019001-ralxw4ad	20	12	may	may	MD
cord-019001-ralxw4ad	20	13	trigger	trigger	VB
cord-019001-ralxw4ad	20	14	the	the	DT
cord-019001-ralxw4ad	20	15	release	release	NN
cord-019001-ralxw4ad	20	16	of	of	IN
cord-019001-ralxw4ad	20	17	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	20	18	substances	substance	NNS
cord-019001-ralxw4ad	20	19	,	,	,
cord-019001-ralxw4ad	20	20	such	such	JJ
cord-019001-ralxw4ad	20	21	as	as	IN
cord-019001-ralxw4ad	20	22	PGI	PGI	NNP
cord-019001-ralxw4ad	20	23	2	2	CD
cord-019001-ralxw4ad	20	24	or	or	CC
cord-019001-ralxw4ad	20	25	NO	no	NN
cord-019001-ralxw4ad	20	26	.	.	.
cord-019001-ralxw4ad	21	1	In	in	IN
cord-019001-ralxw4ad	21	2	fact	fact	NN
cord-019001-ralxw4ad	21	3	,	,	,
cord-019001-ralxw4ad	21	4	data	datum	NNS
cord-019001-ralxw4ad	21	5	indicate	indicate	VBP
cord-019001-ralxw4ad	21	6	that	that	IN
cord-019001-ralxw4ad	21	7	NO	NO	NNP
cord-019001-ralxw4ad	21	8	,	,	,
cord-019001-ralxw4ad	21	9	in	in	IN
cord-019001-ralxw4ad	21	10	particular	particular	JJ
cord-019001-ralxw4ad	21	11	,	,	,
cord-019001-ralxw4ad	21	12	participates	participate	VBZ
cord-019001-ralxw4ad	21	13	in	in	IN
cord-019001-ralxw4ad	21	14	the	the	DT
cord-019001-ralxw4ad	21	15	decrease	decrease	NN
cord-019001-ralxw4ad	21	16	in	in	IN
cord-019001-ralxw4ad	21	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	21	18	vascular	vascular	JJ
cord-019001-ralxw4ad	21	19	resistance	resistance	NN
cord-019001-ralxw4ad	21	20	that	that	WDT
cord-019001-ralxw4ad	21	21	accompanies	accompany	VBZ
cord-019001-ralxw4ad	21	22	increases	increase	NNS
cord-019001-ralxw4ad	21	23	in	in	IN
cord-019001-ralxw4ad	21	24	alveolar	alveolar	NN
cord-019001-ralxw4ad	21	25	and	and	CC
cord-019001-ralxw4ad	21	26	arterial	arterial	JJ
cord-019001-ralxw4ad	21	27	oxygen	oxygen	NN
cord-019001-ralxw4ad	21	28	tension	tension	NN
cord-019001-ralxw4ad	21	29	[	[	-LRB-
cord-019001-ralxw4ad	21	30	7	7	CD
cord-019001-ralxw4ad	21	31	,	,	,
cord-019001-ralxw4ad	21	32	12	12	CD
cord-019001-ralxw4ad	21	33	]	]	-RRB-
cord-019001-ralxw4ad	22	1	However	however	RB
cord-019001-ralxw4ad	22	2	,	,	,
cord-019001-ralxw4ad	22	3	despite	despite	IN
cord-019001-ralxw4ad	22	4	its	-PRON-	PRP$
cord-019001-ralxw4ad	22	5	important	important	JJ
cord-019001-ralxw4ad	22	6	role	role	NN
cord-019001-ralxw4ad	22	7	,	,	,
cord-019001-ralxw4ad	22	8	inhibition	inhibition	NN
cord-019001-ralxw4ad	22	9	of	of	IN
cord-019001-ralxw4ad	22	10	NO	no	DT
cord-019001-ralxw4ad	22	11	does	do	VBZ
cord-019001-ralxw4ad	22	12	not	not	RB
cord-019001-ralxw4ad	22	13	impair	impair	VB
cord-019001-ralxw4ad	22	14	the	the	DT
cord-019001-ralxw4ad	22	15	immediate	immediate	JJ
cord-019001-ralxw4ad	22	16	fall	fall	NN
cord-019001-ralxw4ad	22	17	in	in	IN
cord-019001-ralxw4ad	22	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	22	19	vascular	vascular	JJ
cord-019001-ralxw4ad	22	20	resistance	resistance	NN
cord-019001-ralxw4ad	22	21	seen	see	VBN
cord-019001-ralxw4ad	22	22	after	after	IN
cord-019001-ralxw4ad	22	23	birth	birth	NN
cord-019001-ralxw4ad	22	24	,	,	,
cord-019001-ralxw4ad	22	25	further	further	RB
cord-019001-ralxw4ad	22	26	suggesting	suggest	VBG
cord-019001-ralxw4ad	22	27	that	that	IN
cord-019001-ralxw4ad	22	28	multiple	multiple	JJ
cord-019001-ralxw4ad	22	29	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	22	30	are	be	VBP
cord-019001-ralxw4ad	22	31	involved	involve	VBN
cord-019001-ralxw4ad	22	32	in	in	IN
cord-019001-ralxw4ad	22	33	this	this	DT
cord-019001-ralxw4ad	22	34	transitional	transitional	JJ
cord-019001-ralxw4ad	22	35	physiology	physiology	NN
cord-019001-ralxw4ad	22	36	.	.	.
cord-019001-ralxw4ad	23	1	In	in	IN
cord-019001-ralxw4ad	23	2	fact	fact	NN
cord-019001-ralxw4ad	23	3	,	,	,
cord-019001-ralxw4ad	23	4	recent	recent	JJ
cord-019001-ralxw4ad	23	5	data	datum	NNS
cord-019001-ralxw4ad	23	6	implicate	implicate	VBP
cord-019001-ralxw4ad	23	7	fl	fl	NNP
cord-019001-ralxw4ad	23	8	uid	uid	NN
cord-019001-ralxw4ad	23	9	shear	shear	NN
cord-019001-ralxw4ad	23	10	forces	force	NNS
cord-019001-ralxw4ad	23	11	across	across	IN
cord-019001-ralxw4ad	23	12	endothelial	endothelial	JJ
cord-019001-ralxw4ad	23	13	cells	cell	NNS
cord-019001-ralxw4ad	23	14	,	,	,
cord-019001-ralxw4ad	23	15	which	which	WDT
cord-019001-ralxw4ad	23	16	result	result	VBP
cord-019001-ralxw4ad	23	17	in	in	IN
cord-019001-ralxw4ad	23	18	the	the	DT
cord-019001-ralxw4ad	23	19	production	production	NN
cord-019001-ralxw4ad	23	20	of	of	IN
cord-019001-ralxw4ad	23	21	both	both	CC
cord-019001-ralxw4ad	23	22	NO	no	NN
cord-019001-ralxw4ad	23	23	and	and	CC
cord-019001-ralxw4ad	23	24	PGI	PGI	NNP
cord-019001-ralxw4ad	23	25	2	2	CD
cord-019001-ralxw4ad	23	26	,	,	,
cord-019001-ralxw4ad	23	27	as	as	IN
cord-019001-ralxw4ad	23	28	an	an	DT
cord-019001-ralxw4ad	23	29	additional	additional	JJ
cord-019001-ralxw4ad	23	30	mechanism	mechanism	NN
cord-019001-ralxw4ad	23	31	by	by	IN
cord-019001-ralxw4ad	23	32	which	which	WDT
cord-019001-ralxw4ad	23	33	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	23	34	occurs	occur	VBZ
cord-019001-ralxw4ad	23	35	after	after	IN
cord-019001-ralxw4ad	23	36	birth	birth	NN
cord-019001-ralxw4ad	23	37	[	[	-LRB-
cord-019001-ralxw4ad	23	38	32	32	CD
cord-019001-ralxw4ad	23	39	]	]	-RRB-
cord-019001-ralxw4ad	23	40	.	.	.
cord-019001-ralxw4ad	24	1	It	-PRON-	PRP
cord-019001-ralxw4ad	24	2	is	be	VBZ
cord-019001-ralxw4ad	24	3	possible	possible	JJ
cord-019001-ralxw4ad	24	4	that	that	IN
cord-019001-ralxw4ad	24	5	this	this	DT
cord-019001-ralxw4ad	24	6	particular	particular	JJ
cord-019001-ralxw4ad	24	7	mechanism	mechanism	NN
cord-019001-ralxw4ad	24	8	acts	act	VBZ
cord-019001-ralxw4ad	24	9	to	to	TO
cord-019001-ralxw4ad	24	10	maintain	maintain	VB
cord-019001-ralxw4ad	24	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	24	12	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	24	13	once	once	IN
cord-019001-ralxw4ad	24	14	it	-PRON-	PRP
cord-019001-ralxw4ad	24	15	has	have	VBZ
cord-019001-ralxw4ad	24	16	been	be	VBN
cord-019001-ralxw4ad	24	17	established	establish	VBN
cord-019001-ralxw4ad	24	18	by	by	IN
cord-019001-ralxw4ad	24	19	the	the	DT
cord-019001-ralxw4ad	24	20	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	24	21	described	describe	VBN
cord-019001-ralxw4ad	24	22	earlier	early	RBR
cord-019001-ralxw4ad	24	23	.	.	.
cord-019001-ralxw4ad	25	1	In	in	IN
cord-019001-ralxw4ad	25	2	general	general	JJ
cord-019001-ralxw4ad	25	3	,	,	,
cord-019001-ralxw4ad	25	4	the	the	DT
cord-019001-ralxw4ad	25	5	dramatic	dramatic	JJ
cord-019001-ralxw4ad	25	6	increase	increase	NN
cord-019001-ralxw4ad	25	7	in	in	IN
cord-019001-ralxw4ad	25	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	25	9	blood	blood	NN
cord-019001-ralxw4ad	25	10	fl	fl	NNP
cord-019001-ralxw4ad	25	11	ow	ow	UH
cord-019001-ralxw4ad	25	12	with	with	IN
cord-019001-ralxw4ad	25	13	the	the	DT
cord-019001-ralxw4ad	25	14	initiation	initiation	NN
cord-019001-ralxw4ad	25	15	of	of	IN
cord-019001-ralxw4ad	25	16	ventilation	ventilation	NN
cord-019001-ralxw4ad	25	17	and	and	CC
cord-019001-ralxw4ad	25	18	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	25	19	at	at	IN
cord-019001-ralxw4ad	25	20	birth	birth	NN
cord-019001-ralxw4ad	25	21	refl	refl	NNP
cord-019001-ralxw4ad	25	22	ects	ects	NNP
cord-019001-ralxw4ad	25	23	a	a	DT
cord-019001-ralxw4ad	25	24	shift	shift	NN
cord-019001-ralxw4ad	25	25	from	from	IN
cord-019001-ralxw4ad	25	26	active	active	JJ
cord-019001-ralxw4ad	25	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	25	28	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	25	29	in	in	IN
cord-019001-ralxw4ad	25	30	the	the	DT
cord-019001-ralxw4ad	25	31	fetus	fetus	NN
cord-019001-ralxw4ad	25	32	to	to	IN
cord-019001-ralxw4ad	25	33	active	active	JJ
cord-019001-ralxw4ad	25	34	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	25	35	vasodilatation	vasodilatation	NN
cord-019001-ralxw4ad	25	36	in	in	IN
cord-019001-ralxw4ad	25	37	the	the	DT
cord-019001-ralxw4ad	25	38	newborn	newborn	NN
cord-019001-ralxw4ad	25	39	.	.	.
cord-019001-ralxw4ad	26	1	Failure	failure	NN
cord-019001-ralxw4ad	26	2	to	to	TO
cord-019001-ralxw4ad	26	3	undergo	undergo	VB
cord-019001-ralxw4ad	26	4	this	this	DT
cord-019001-ralxw4ad	26	5	normal	normal	JJ
cord-019001-ralxw4ad	26	6	transition	transition	NN
cord-019001-ralxw4ad	26	7	contributes	contribute	VBZ
cord-019001-ralxw4ad	26	8	substantially	substantially	RB
cord-019001-ralxw4ad	26	9	to	to	IN
cord-019001-ralxw4ad	26	10	the	the	DT
cord-019001-ralxw4ad	26	11	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	26	12	of	of	IN
cord-019001-ralxw4ad	26	13	many	many	JJ
cord-019001-ralxw4ad	26	14	neonatal	neonatal	JJ
cord-019001-ralxw4ad	26	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	26	16	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	26	17	disorders	disorder	NNS
cord-019001-ralxw4ad	26	18	,	,	,
cord-019001-ralxw4ad	26	19	including	include	VBG
cord-019001-ralxw4ad	26	20	bronchopulmonary	bronchopulmonary	JJ
cord-019001-ralxw4ad	26	21	dysplasia	dysplasia	NN
cord-019001-ralxw4ad	26	22	,	,	,
cord-019001-ralxw4ad	26	23	persistent	persistent	JJ
cord-019001-ralxw4ad	26	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	26	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	26	26	of	of	IN
cord-019001-ralxw4ad	26	27	the	the	DT
cord-019001-ralxw4ad	26	28	newborn	newborn	JJ
cord-019001-ralxw4ad	26	29	,	,	,
cord-019001-ralxw4ad	26	30	chronic	chronic	JJ
cord-019001-ralxw4ad	26	31	lung	lung	NN
cord-019001-ralxw4ad	26	32	disease	disease	NN
cord-019001-ralxw4ad	26	33	,	,	,
cord-019001-ralxw4ad	26	34	and	and	CC
cord-019001-ralxw4ad	26	35	congenital	congenital	JJ
cord-019001-ralxw4ad	26	36	heart	heart	NN
cord-019001-ralxw4ad	26	37	disease	disease	NN
cord-019001-ralxw4ad	26	38	[	[	-LRB-
cord-019001-ralxw4ad	26	39	25	25	CD
cord-019001-ralxw4ad	26	40	,	,	,
cord-019001-ralxw4ad	26	41	.	.	.
cord-019001-ralxw4ad	27	1	The	the	DT
cord-019001-ralxw4ad	27	2	successful	successful	JJ
cord-019001-ralxw4ad	27	3	transition	transition	NN
cord-019001-ralxw4ad	27	4	from	from	IN
cord-019001-ralxw4ad	27	5	the	the	DT
cord-019001-ralxw4ad	27	6	fetal	fetal	NN
cord-019001-ralxw4ad	27	7	to	to	IN
cord-019001-ralxw4ad	27	8	the	the	DT
cord-019001-ralxw4ad	27	9	postnatal	postnatal	JJ
cord-019001-ralxw4ad	27	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	27	11	circulation	circulation	NN
cord-019001-ralxw4ad	27	12	is	be	VBZ
cord-019001-ralxw4ad	27	13	marked	mark	VBN
cord-019001-ralxw4ad	27	14	by	by	IN
cord-019001-ralxw4ad	27	15	the	the	DT
cord-019001-ralxw4ad	27	16	maintenance	maintenance	NN
cord-019001-ralxw4ad	27	17	of	of	IN
cord-019001-ralxw4ad	27	18	the	the	DT
cord-019001-ralxw4ad	27	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	27	20	vasculature	vasculature	NN
cord-019001-ralxw4ad	27	21	in	in	IN
cord-019001-ralxw4ad	27	22	a	a	DT
cord-019001-ralxw4ad	27	23	dilated	dilated	JJ
cord-019001-ralxw4ad	27	24	,	,	,
cord-019001-ralxw4ad	27	25	low	low	JJ
cord-019001-ralxw4ad	27	26	-	-	HYPH
cord-019001-ralxw4ad	27	27	resistance	resistance	NN
cord-019001-ralxw4ad	27	28	state	state	NN
cord-019001-ralxw4ad	27	29	[	[	-LRB-
cord-019001-ralxw4ad	27	30	65	65	CD
cord-019001-ralxw4ad	27	31	]	]	-RRB-
cord-019001-ralxw4ad	27	32	.	.	.
cord-019001-ralxw4ad	28	1	Recent	recent	JJ
cord-019001-ralxw4ad	28	2	evidence	evidence	NN
cord-019001-ralxw4ad	28	3	suggests	suggest	VBZ
cord-019001-ralxw4ad	28	4	that	that	DT
cord-019001-ralxw4ad	28	5	basal	basal	NN
cord-019001-ralxw4ad	28	6	NO	no	DT
cord-019001-ralxw4ad	28	7	release	release	NN
cord-019001-ralxw4ad	28	8	,	,	,
cord-019001-ralxw4ad	28	9	and	and	CC
cord-019001-ralxw4ad	28	10	the	the	DT
cord-019001-ralxw4ad	28	11	subsequent	subsequent	JJ
cord-019001-ralxw4ad	28	12	increase	increase	NN
cord-019001-ralxw4ad	28	13	in	in	IN
cord-019001-ralxw4ad	28	14	smooth	smooth	JJ
cord-019001-ralxw4ad	28	15	muscle	muscle	NN
cord-019001-ralxw4ad	28	16	cell	cell	NN
cord-019001-ralxw4ad	28	17	cyclic	cyclic	JJ
cord-019001-ralxw4ad	28	18	guanosine	guanosine	NN
cord-019001-ralxw4ad	28	19	monophosphate	monophosphate	NN
cord-019001-ralxw4ad	28	20	(	(	-LRB-
cord-019001-ralxw4ad	28	21	cGMP	cGMP	NNP
cord-019001-ralxw4ad	28	22	)	)	-RRB-
cord-019001-ralxw4ad	28	23	concentrations	concentration	NNS
cord-019001-ralxw4ad	28	24	,	,	,
cord-019001-ralxw4ad	28	25	in	in	IN
cord-019001-ralxw4ad	28	26	part	part	NN
cord-019001-ralxw4ad	28	27	mediate	mediate	VBP
cord-019001-ralxw4ad	28	28	the	the	DT
cord-019001-ralxw4ad	28	29	low	low	JJ
cord-019001-ralxw4ad	28	30	resting	rest	VBG
cord-019001-ralxw4ad	28	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	28	32	vascular	vascular	JJ
cord-019001-ralxw4ad	28	33	resistance	resistance	NN
cord-019001-ralxw4ad	28	34	of	of	IN
cord-019001-ralxw4ad	28	35	the	the	DT
cord-019001-ralxw4ad	28	36	newborn	newborn	JJ
cord-019001-ralxw4ad	28	37	[	[	-LRB-
cord-019001-ralxw4ad	28	38	66	66	CD
cord-019001-ralxw4ad	28	39	]	]	-RRB-
cord-019001-ralxw4ad	28	40	.	.	.
cord-019001-ralxw4ad	29	1	Other	other	JJ
cord-019001-ralxw4ad	29	2	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	29	3	substances	substance	NNS
cord-019001-ralxw4ad	29	4	,	,	,
cord-019001-ralxw4ad	29	5	including	include	VBG
cord-019001-ralxw4ad	29	6	histamine	histamine	NN
cord-019001-ralxw4ad	29	7	,	,	,
cord-019001-ralxw4ad	29	8	5-hydroxytryptamine	5-hydroxytryptamine	CD
cord-019001-ralxw4ad	29	9	,	,	,
cord-019001-ralxw4ad	29	10	bradykinin	bradykinin	NN
cord-019001-ralxw4ad	29	11	,	,	,
cord-019001-ralxw4ad	29	12	and	and	CC
cord-019001-ralxw4ad	29	13	metabolites	metabolite	NNS
cord-019001-ralxw4ad	29	14	of	of	IN
cord-019001-ralxw4ad	29	15	arachidonic	arachidonic	JJ
cord-019001-ralxw4ad	29	16	acid	acid	NN
cord-019001-ralxw4ad	29	17	by	by	IN
cord-019001-ralxw4ad	29	18	the	the	DT
cord-019001-ralxw4ad	29	19	cyclooxygenase	cyclooxygenase	NN
cord-019001-ralxw4ad	29	20	and	and	CC
cord-019001-ralxw4ad	29	21	lipoxygenase	lipoxygenase	NN
cord-019001-ralxw4ad	29	22	pathways	pathway	NNS
cord-019001-ralxw4ad	29	23	,	,	,
cord-019001-ralxw4ad	29	24	have	have	VBP
cord-019001-ralxw4ad	29	25	also	also	RB
cord-019001-ralxw4ad	29	26	been	be	VBN
cord-019001-ralxw4ad	29	27	implicated	implicate	VBN
cord-019001-ralxw4ad	29	28	in	in	IN
cord-019001-ralxw4ad	29	29	mediating	mediate	VBG
cord-019001-ralxw4ad	29	30	postnatal	postnatal	JJ
cord-019001-ralxw4ad	29	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	29	32	vascular	vascular	JJ
cord-019001-ralxw4ad	29	33	tone	tone	NN
cord-019001-ralxw4ad	29	34	;	;	:
cord-019001-ralxw4ad	29	35	however	however	RB
cord-019001-ralxw4ad	29	36	,	,	,
cord-019001-ralxw4ad	29	37	their	-PRON-	PRP$
cord-019001-ralxw4ad	29	38	roles	role	NNS
cord-019001-ralxw4ad	29	39	are	be	VBP
cord-019001-ralxw4ad	29	40	not	not	RB
cord-019001-ralxw4ad	29	41	well	well	RB
cord-019001-ralxw4ad	29	42	elucidated	elucidate	VBN
cord-019001-ralxw4ad	29	43	.	.	.
cord-019001-ralxw4ad	30	1	Two	two	CD
cord-019001-ralxw4ad	30	2	of	of	IN
cord-019001-ralxw4ad	30	3	the	the	DT
cord-019001-ralxw4ad	30	4	most	most	RBS
cord-019001-ralxw4ad	30	5	important	important	JJ
cord-019001-ralxw4ad	30	6	factors	factor	NNS
cord-019001-ralxw4ad	30	7	affecting	affect	VBG
cord-019001-ralxw4ad	30	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	30	9	vascular	vascular	JJ
cord-019001-ralxw4ad	30	10	resistance	resistance	NN
cord-019001-ralxw4ad	30	11	in	in	IN
cord-019001-ralxw4ad	30	12	the	the	DT
cord-019001-ralxw4ad	30	13	postnatal	postnatal	JJ
cord-019001-ralxw4ad	30	14	period	period	NN
cord-019001-ralxw4ad	30	15	are	be	VBP
cord-019001-ralxw4ad	30	16	oxygen	oxygen	NN
cord-019001-ralxw4ad	30	17	concentration	concentration	NN
cord-019001-ralxw4ad	30	18	and	and	CC
cord-019001-ralxw4ad	30	19	pH.	ph.	NN
cord-019001-ralxw4ad	30	20	Decreasing	decrease	VBG
cord-019001-ralxw4ad	30	21	oxygen	oxygen	NN
cord-019001-ralxw4ad	30	22	tension	tension	NN
cord-019001-ralxw4ad	30	23	and	and	CC
cord-019001-ralxw4ad	30	24	decreases	decrease	NNS
cord-019001-ralxw4ad	30	25	in	in	IN
cord-019001-ralxw4ad	30	26	pH	pH	NNP
cord-019001-ralxw4ad	30	27	elicit	elicit	VB
cord-019001-ralxw4ad	30	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	30	29	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	30	30	[	[	-LRB-
cord-019001-ralxw4ad	30	31	67	67	CD
cord-019001-ralxw4ad	30	32	]	]	-RRB-
cord-019001-ralxw4ad	30	33	.	.	.
cord-019001-ralxw4ad	31	1	Alveolar	alveolar	JJ
cord-019001-ralxw4ad	31	2	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	31	3	constricts	constrict	VBZ
cord-019001-ralxw4ad	31	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	31	5	arterioles	arteriole	NNS
cord-019001-ralxw4ad	31	6	,	,	,
cord-019001-ralxw4ad	31	7	diverting	divert	VBG
cord-019001-ralxw4ad	31	8	blood	blood	NN
cord-019001-ralxw4ad	31	9	fl	fl	NNP
cord-019001-ralxw4ad	31	10	ow	ow	NN
cord-019001-ralxw4ad	31	11	away	away	RB
cord-019001-ralxw4ad	31	12	from	from	IN
cord-019001-ralxw4ad	31	13	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	31	14	lung	lung	NN
cord-019001-ralxw4ad	31	15	segments	segment	NNS
cord-019001-ralxw4ad	31	16	,	,	,
cord-019001-ralxw4ad	31	17	toward	toward	IN
cord-019001-ralxw4ad	31	18	well	well	RB
cord-019001-ralxw4ad	31	19	-	-	HYPH
cord-019001-ralxw4ad	31	20	oxygenated	oxygenated	JJ
cord-019001-ralxw4ad	31	21	segments	segment	NNS
cord-019001-ralxw4ad	31	22	,	,	,
cord-019001-ralxw4ad	31	23	thus	thus	RB
cord-019001-ralxw4ad	31	24	enhancing	enhance	VBG
cord-019001-ralxw4ad	31	25	ventilationperfusion	ventilationperfusion	NN
cord-019001-ralxw4ad	31	26	matching	match	VBG
cord-019001-ralxw4ad	31	27	[	[	-LRB-
cord-019001-ralxw4ad	31	28	68	68	CD
cord-019001-ralxw4ad	31	29	]	]	-RRB-
cord-019001-ralxw4ad	31	30	.	.	.
cord-019001-ralxw4ad	32	1	This	this	DT
cord-019001-ralxw4ad	32	2	response	response	NN
cord-019001-ralxw4ad	32	3	to	to	IN
cord-019001-ralxw4ad	32	4	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	32	5	,	,	,
cord-019001-ralxw4ad	32	6	unique	unique	JJ
cord-019001-ralxw4ad	32	7	to	to	IN
cord-019001-ralxw4ad	32	8	the	the	DT
cord-019001-ralxw4ad	32	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	32	10	vasculature	vasculature	NN
cord-019001-ralxw4ad	32	11	,	,	,
cord-019001-ralxw4ad	32	12	is	be	VBZ
cord-019001-ralxw4ad	32	13	greater	great	JJR
cord-019001-ralxw4ad	32	14	in	in	IN
cord-019001-ralxw4ad	32	15	the	the	DT
cord-019001-ralxw4ad	32	16	younger	young	JJR
cord-019001-ralxw4ad	32	17	animal	animal	NN
cord-019001-ralxw4ad	32	18	than	than	IN
cord-019001-ralxw4ad	32	19	in	in	IN
cord-019001-ralxw4ad	32	20	the	the	DT
cord-019001-ralxw4ad	32	21	adult	adult	NN
cord-019001-ralxw4ad	32	22	[	[	-LRB-
cord-019001-ralxw4ad	32	23	69	69	CD
cord-019001-ralxw4ad	32	24	]	]	-RRB-
cord-019001-ralxw4ad	32	25	.	.	.
cord-019001-ralxw4ad	33	1	Indeed	indeed	RB
cord-019001-ralxw4ad	33	2	,	,	,
cord-019001-ralxw4ad	33	3	in	in	IN
cord-019001-ralxw4ad	33	4	most	most	JJS
cord-019001-ralxw4ad	33	5	vascular	vascular	JJ
cord-019001-ralxw4ad	33	6	beds	bed	NNS
cord-019001-ralxw4ad	33	7	(	(	-LRB-
cord-019001-ralxw4ad	33	8	e.g.	e.g.	RB
cord-019001-ralxw4ad	33	9	,	,	,
cord-019001-ralxw4ad	33	10	cerebral	cerebral	JJ
cord-019001-ralxw4ad	33	11	vasculature	vasculature	NN
cord-019001-ralxw4ad	33	12	)	)	-RRB-
cord-019001-ralxw4ad	33	13	,	,	,
cord-019001-ralxw4ad	33	14	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	33	15	is	be	VBZ
cord-019001-ralxw4ad	33	16	a	a	DT
cord-019001-ralxw4ad	33	17	potent	potent	JJ
cord-019001-ralxw4ad	33	18	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	33	19	.	.	.
cord-019001-ralxw4ad	34	1	The	the	DT
cord-019001-ralxw4ad	34	2	exact	exact	JJ
cord-019001-ralxw4ad	34	3	mechanism	mechanism	NN
cord-019001-ralxw4ad	34	4	of	of	IN
cord-019001-ralxw4ad	34	5	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	34	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	34	7	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	34	8	remains	remain	VBZ
cord-019001-ralxw4ad	34	9	incompletely	incompletely	RB
cord-019001-ralxw4ad	34	10	under	under	RB
cord-019001-ralxw4ad	34	11	-	-	HYPH
cord-019001-ralxw4ad	34	12	stood	stand	VBN
cord-019001-ralxw4ad	34	13	but	but	CC
cord-019001-ralxw4ad	34	14	likely	likely	JJ
cord-019001-ralxw4ad	34	15	involves	involve	VBZ
cord-019001-ralxw4ad	34	16	changes	change	NNS
cord-019001-ralxw4ad	34	17	in	in	IN
cord-019001-ralxw4ad	34	18	the	the	DT
cord-019001-ralxw4ad	34	19	local	local	JJ
cord-019001-ralxw4ad	34	20	concentration	concentration	NN
cord-019001-ralxw4ad	34	21	of	of	IN
cord-019001-ralxw4ad	34	22	reactive	reactive	JJ
cord-019001-ralxw4ad	34	23	oxygen	oxygen	NN
cord-019001-ralxw4ad	34	24	species	specie	NNS
cord-019001-ralxw4ad	34	25	that	that	WDT
cord-019001-ralxw4ad	34	26	in	in	IN
cord-019001-ralxw4ad	34	27	turn	turn	NN
cord-019001-ralxw4ad	34	28	regulate	regulate	VBP
cord-019001-ralxw4ad	34	29	voltage	voltage	NN
cord-019001-ralxw4ad	34	30	-	-	HYPH
cord-019001-ralxw4ad	34	31	gated	gate	VBN
cord-019001-ralxw4ad	34	32	potassium	potassium	NN
cord-019001-ralxw4ad	34	33	channels	channel	NNS
cord-019001-ralxw4ad	34	34	and	and	CC
cord-019001-ralxw4ad	34	35	calcium	calcium	NN
cord-019001-ralxw4ad	34	36	channels	channel	NNS
cord-019001-ralxw4ad	34	37	[	[	-LRB-
cord-019001-ralxw4ad	34	38	66	66	CD
cord-019001-ralxw4ad	34	39	,	,	,
cord-019001-ralxw4ad	34	40	70	70	CD
cord-019001-ralxw4ad	34	41	]	]	-RRB-
cord-019001-ralxw4ad	34	42	.	.	.
cord-019001-ralxw4ad	35	1	Acidosis	acidosis	NN
cord-019001-ralxw4ad	35	2	potentiates	potentiate	VBZ
cord-019001-ralxw4ad	35	3	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	35	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	35	5	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	35	6	,	,	,
cord-019001-ralxw4ad	35	7	whereas	whereas	IN
cord-019001-ralxw4ad	35	8	alkalosis	alkalosis	NN
cord-019001-ralxw4ad	35	9	reduces	reduce	VBZ
cord-019001-ralxw4ad	35	10	it	-PRON-	PRP
cord-019001-ralxw4ad	35	11	[	[	-LRB-
cord-019001-ralxw4ad	35	12	71	71	CD
cord-019001-ralxw4ad	35	13	]	]	-RRB-
cord-019001-ralxw4ad	35	14	.	.	.
cord-019001-ralxw4ad	36	1	The	the	DT
cord-019001-ralxw4ad	36	2	exact	exact	JJ
cord-019001-ralxw4ad	36	3	mechanism	mechanism	NN
cord-019001-ralxw4ad	36	4	of	of	IN
cord-019001-ralxw4ad	36	5	pH	ph	NN
cord-019001-ralxw4ad	36	6	-	-	HYPH
cord-019001-ralxw4ad	36	7	mediated	mediate	VBN
cord-019001-ralxw4ad	36	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	36	9	vascular	vascular	JJ
cord-019001-ralxw4ad	36	10	reactivity	reactivity	NN
cord-019001-ralxw4ad	36	11	also	also	RB
cord-019001-ralxw4ad	36	12	remains	remain	VBZ
cord-019001-ralxw4ad	36	13	incompletely	incompletely	RB
cord-019001-ralxw4ad	36	14	understood	understand	VBN
cord-019001-ralxw4ad	36	15	but	but	CC
cord-019001-ralxw4ad	36	16	appears	appear	VBZ
cord-019001-ralxw4ad	36	17	to	to	TO
cord-019001-ralxw4ad	36	18	be	be	VB
cord-019001-ralxw4ad	36	19	independent	independent	JJ
cord-019001-ralxw4ad	36	20	of	of	IN
cord-019001-ralxw4ad	36	21	PaCO	paco	NN
cord-019001-ralxw4ad	36	22	2	2	CD
cord-019001-ralxw4ad	36	23	[	[	-LRB-
cord-019001-ralxw4ad	36	24	72	72	CD
cord-019001-ralxw4ad	36	25	]	]	-RRB-
cord-019001-ralxw4ad	36	26	.	.	.
cord-019001-ralxw4ad	37	1	Recent	recent	JJ
cord-019001-ralxw4ad	37	2	data	datum	NNS
cord-019001-ralxw4ad	37	3	suggest	suggest	VBP
cord-019001-ralxw4ad	37	4	that	that	IN
cord-019001-ralxw4ad	37	5	potassium	potassium	NN
cord-019001-ralxw4ad	37	6	channels	channel	NNS
cord-019001-ralxw4ad	37	7	play	play	VBP
cord-019001-ralxw4ad	37	8	an	an	DT
cord-019001-ralxw4ad	37	9	important	important	JJ
cord-019001-ralxw4ad	37	10	role	role	NN
cord-019001-ralxw4ad	37	11	in	in	IN
cord-019001-ralxw4ad	37	12	mediating	mediate	VBG
cord-019001-ralxw4ad	37	13	these	these	DT
cord-019001-ralxw4ad	37	14	responses	response	NNS
cord-019001-ralxw4ad	37	15	as	as	RB
cord-019001-ralxw4ad	37	16	well	well	RB
cord-019001-ralxw4ad	37	17	[	[	-LRB-
cord-019001-ralxw4ad	37	18	73	73	CD
cord-019001-ralxw4ad	37	19	]	]	-RRB-
cord-019001-ralxw4ad	37	20	.	.	.
cord-019001-ralxw4ad	38	1	Manipulating	manipulate	VBG
cord-019001-ralxw4ad	38	2	alveolar	alveolar	JJ
cord-019001-ralxw4ad	38	3	oxygen	oxygen	NN
cord-019001-ralxw4ad	38	4	tension	tension	NN
cord-019001-ralxw4ad	38	5	and	and	CC
cord-019001-ralxw4ad	38	6	systemic	systemic	JJ
cord-019001-ralxw4ad	38	7	arterial	arterial	NN
cord-019001-ralxw4ad	39	1	pH	pH	NNP
cord-019001-ralxw4ad	39	2	are	be	VBP
cord-019001-ralxw4ad	39	3	fundamental	fundamental	JJ
cord-019001-ralxw4ad	39	4	approaches	approach	NNS
cord-019001-ralxw4ad	39	5	to	to	IN
cord-019001-ralxw4ad	39	6	changing	change	VBG
cord-019001-ralxw4ad	39	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	39	8	vascular	vascular	JJ
cord-019001-ralxw4ad	39	9	tone	tone	NN
cord-019001-ralxw4ad	39	10	in	in	IN
cord-019001-ralxw4ad	39	11	the	the	DT
cord-019001-ralxw4ad	39	12	critical	critical	JJ
cord-019001-ralxw4ad	39	13	care	care	NN
cord-019001-ralxw4ad	39	14	setting	setting	NN
cord-019001-ralxw4ad	39	15	.	.	.
cord-019001-ralxw4ad	40	1	Alveolar	alveolar	JJ
cord-019001-ralxw4ad	40	2	hyperoxia	hyperoxia	NN
cord-019001-ralxw4ad	40	3	and	and	CC
cord-019001-ralxw4ad	40	4	alkalosis	alkalosis	NN
cord-019001-ralxw4ad	40	5	are	be	VBP
cord-019001-ralxw4ad	40	6	often	often	RB
cord-019001-ralxw4ad	40	7	used	use	VBN
cord-019001-ralxw4ad	40	8	to	to	TO
cord-019001-ralxw4ad	40	9	decrease	decrease	VB
cord-019001-ralxw4ad	40	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	40	11	vascular	vascular	JJ
cord-019001-ralxw4ad	40	12	tone	tone	NN
cord-019001-ralxw4ad	40	13	because	because	IN
cord-019001-ralxw4ad	40	14	they	-PRON-	PRP
cord-019001-ralxw4ad	40	15	generally	generally	RB
cord-019001-ralxw4ad	40	16	relieve	relieve	VBP
cord-019001-ralxw4ad	40	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	40	18	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	40	19	with	with	IN
cord-019001-ralxw4ad	40	20	little	little	JJ
cord-019001-ralxw4ad	40	21	effect	effect	NN
cord-019001-ralxw4ad	40	22	on	on	IN
cord-019001-ralxw4ad	40	23	the	the	DT
cord-019001-ralxw4ad	40	24	systemic	systemic	JJ
cord-019001-ralxw4ad	40	25	circulation	circulation	NN
cord-019001-ralxw4ad	40	26	as	as	IN
cord-019001-ralxw4ad	40	27	a	a	DT
cord-019001-ralxw4ad	40	28	whole	whole	NN
cord-019001-ralxw4ad	40	29	.	.	.
cord-019001-ralxw4ad	41	1	However	however	RB
cord-019001-ralxw4ad	41	2	,	,	,
cord-019001-ralxw4ad	41	3	severe	severe	JJ
cord-019001-ralxw4ad	41	4	alkalosis	alkalosis	NN
cord-019001-ralxw4ad	41	5	is	be	VBZ
cord-019001-ralxw4ad	41	6	generally	generally	RB
cord-019001-ralxw4ad	41	7	avoided	avoid	VBN
cord-019001-ralxw4ad	41	8	because	because	IN
cord-019001-ralxw4ad	41	9	of	of	IN
cord-019001-ralxw4ad	41	10	the	the	DT
cord-019001-ralxw4ad	41	11	detrimental	detrimental	JJ
cord-019001-ralxw4ad	41	12	effects	effect	NNS
cord-019001-ralxw4ad	41	13	of	of	IN
cord-019001-ralxw4ad	41	14	severe	severe	JJ
cord-019001-ralxw4ad	41	15	hypocarbia	hypocarbia	NN
cord-019001-ralxw4ad	41	16	or	or	CC
cord-019001-ralxw4ad	41	17	alkalosis	alkalosis	NN
cord-019001-ralxw4ad	41	18	on	on	IN
cord-019001-ralxw4ad	41	19	cerebral	cerebral	JJ
cord-019001-ralxw4ad	41	20	and	and	CC
cord-019001-ralxw4ad	41	21	myocardial	myocardial	JJ
cord-019001-ralxw4ad	41	22	blood	blood	NN
cord-019001-ralxw4ad	41	23	fl	fl	NNP
cord-019001-ralxw4ad	41	24	ow	ow	UH
cord-019001-ralxw4ad	41	25	(	(	-LRB-
cord-019001-ralxw4ad	41	26	see	see	VB
cord-019001-ralxw4ad	41	27	General	General	NNP
cord-019001-ralxw4ad	41	28	Treatment	Treatment	NNP
cord-019001-ralxw4ad	41	29	Approach	Approach	NNP
cord-019001-ralxw4ad	41	30	,	,	,
cord-019001-ralxw4ad	41	31	later	later	RB
cord-019001-ralxw4ad	41	32	)	)	-RRB-
cord-019001-ralxw4ad	41	33	[	[	-LRB-
cord-019001-ralxw4ad	41	34	6	6	CD
cord-019001-ralxw4ad	41	35	,	,	,
cord-019001-ralxw4ad	41	36	8	8	CD
cord-019001-ralxw4ad	41	37	]	]	-RRB-
cord-019001-ralxw4ad	41	38	.	.	.
cord-019001-ralxw4ad	42	1	Despite	despite	IN
cord-019001-ralxw4ad	42	2	extensive	extensive	JJ
cord-019001-ralxw4ad	42	3	innervation	innervation	NN
cord-019001-ralxw4ad	42	4	of	of	IN
cord-019001-ralxw4ad	42	5	the	the	DT
cord-019001-ralxw4ad	42	6	lung	lung	NN
cord-019001-ralxw4ad	42	7	,	,	,
cord-019001-ralxw4ad	42	8	neural	neural	JJ
cord-019001-ralxw4ad	42	9	input	input	NN
cord-019001-ralxw4ad	42	10	is	be	VBZ
cord-019001-ralxw4ad	42	11	not	not	RB
cord-019001-ralxw4ad	42	12	a	a	DT
cord-019001-ralxw4ad	42	13	major	major	JJ
cord-019001-ralxw4ad	42	14	determinant	determinant	NN
cord-019001-ralxw4ad	42	15	of	of	IN
cord-019001-ralxw4ad	42	16	basal	basal	JJ
cord-019001-ralxw4ad	42	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	42	18	vascular	vascular	JJ
cord-019001-ralxw4ad	42	19	tone	tone	NN
cord-019001-ralxw4ad	42	20	.	.	.
cord-019001-ralxw4ad	43	1	However	however	RB
cord-019001-ralxw4ad	43	2	,	,	,
cord-019001-ralxw4ad	43	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	43	4	neurohumoral	neurohumoral	JJ
cord-019001-ralxw4ad	43	5	receptors	receptor	NNS
cord-019001-ralxw4ad	43	6	are	be	VBP
cord-019001-ralxw4ad	43	7	sensitive	sensitive	JJ
cord-019001-ralxw4ad	43	8	to	to	IN
cord-019001-ralxw4ad	43	9	α	α	NN
cord-019001-ralxw4ad	43	10	-	-	HYPH
cord-019001-ralxw4ad	43	11	adrenergic	adrenergic	NN
cord-019001-ralxw4ad	43	12	,	,	,
cord-019001-ralxw4ad	43	13	β	β	NN
cord-019001-ralxw4ad	43	14	-	-	HYPH
cord-019001-ralxw4ad	43	15	adrenergic	adrenergic	NN
cord-019001-ralxw4ad	43	16	,	,	,
cord-019001-ralxw4ad	43	17	and	and	CC
cord-019001-ralxw4ad	43	18	dopaminergic	dopaminergic	JJ
cord-019001-ralxw4ad	43	19	agonists	agonist	NNS
cord-019001-ralxw4ad	43	20	[	[	-LRB-
cord-019001-ralxw4ad	43	21	74	74	CD
cord-019001-ralxw4ad	43	22	,	,	,
cord-019001-ralxw4ad	43	23	75	75	CD
cord-019001-ralxw4ad	43	24	]	]	-RRB-
cord-019001-ralxw4ad	43	25	.	.	.
cord-019001-ralxw4ad	44	1	Therefore	therefore	RB
cord-019001-ralxw4ad	44	2	,	,	,
cord-019001-ralxw4ad	44	3	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	44	4	agents	agent	NNS
cord-019001-ralxw4ad	44	5	that	that	WDT
cord-019001-ralxw4ad	44	6	stimulate	stimulate	VBP
cord-019001-ralxw4ad	44	7	these	these	DT
cord-019001-ralxw4ad	44	8	receptors	receptor	NNS
cord-019001-ralxw4ad	44	9	will	will	MD
cord-019001-ralxw4ad	44	10	affect	affect	VB
cord-019001-ralxw4ad	44	11	the	the	DT
cord-019001-ralxw4ad	44	12	vascular	vascular	JJ
cord-019001-ralxw4ad	44	13	tone	tone	NN
cord-019001-ralxw4ad	44	14	of	of	IN
cord-019001-ralxw4ad	44	15	both	both	CC
cord-019001-ralxw4ad	44	16	the	the	DT
cord-019001-ralxw4ad	44	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	44	18	and	and	CC
cord-019001-ralxw4ad	44	19	systemic	systemic	JJ
cord-019001-ralxw4ad	44	20	circulations	circulation	NNS
cord-019001-ralxw4ad	44	21	.	.	.
cord-019001-ralxw4ad	45	1	Alterations	alteration	NNS
cord-019001-ralxw4ad	45	2	in	in	IN
cord-019001-ralxw4ad	45	3	vascular	vascular	JJ
cord-019001-ralxw4ad	45	4	tone	tone	NN
cord-019001-ralxw4ad	45	5	,	,	,
cord-019001-ralxw4ad	45	6	in	in	IN
cord-019001-ralxw4ad	45	7	response	response	NN
cord-019001-ralxw4ad	45	8	to	to	IN
cord-019001-ralxw4ad	45	9	a	a	DT
cord-019001-ralxw4ad	45	10	given	give	VBN
cord-019001-ralxw4ad	45	11	agent	agent	NN
cord-019001-ralxw4ad	45	12	,	,	,
cord-019001-ralxw4ad	45	13	are	be	VBP
cord-019001-ralxw4ad	45	14	dependent	dependent	JJ
cord-019001-ralxw4ad	45	15	on	on	IN
cord-019001-ralxw4ad	45	16	the	the	DT
cord-019001-ralxw4ad	45	17	relative	relative	JJ
cord-019001-ralxw4ad	45	18	tone	tone	NN
cord-019001-ralxw4ad	45	19	of	of	IN
cord-019001-ralxw4ad	45	20	the	the	DT
cord-019001-ralxw4ad	45	21	vascular	vascular	JJ
cord-019001-ralxw4ad	45	22	bed	bed	NN
cord-019001-ralxw4ad	45	23	at	at	IN
cord-019001-ralxw4ad	45	24	a	a	DT
cord-019001-ralxw4ad	45	25	given	give	VBN
cord-019001-ralxw4ad	45	26	time	time	NN
cord-019001-ralxw4ad	45	27	.	.	.
cord-019001-ralxw4ad	46	1	Therefore	therefore	RB
cord-019001-ralxw4ad	46	2	,	,	,
cord-019001-ralxw4ad	46	3	the	the	DT
cord-019001-ralxw4ad	46	4	response	response	NN
cord-019001-ralxw4ad	46	5	of	of	IN
cord-019001-ralxw4ad	46	6	these	these	DT
cord-019001-ralxw4ad	46	7	agents	agent	NNS
cord-019001-ralxw4ad	46	8	is	be	VBZ
cord-019001-ralxw4ad	46	9	diffi	diffi	JJ
cord-019001-ralxw4ad	46	10	cult	cult	NN
cord-019001-ralxw4ad	46	11	to	to	TO
cord-019001-ralxw4ad	46	12	predict	predict	VB
cord-019001-ralxw4ad	46	13	in	in	IN
cord-019001-ralxw4ad	46	14	an	an	DT
cord-019001-ralxw4ad	46	15	individual	individual	JJ
cord-019001-ralxw4ad	46	16	critically	critically	RB
cord-019001-ralxw4ad	46	17	ill	ill	JJ
cord-019001-ralxw4ad	46	18	patient	patient	NN
cord-019001-ralxw4ad	46	19	.	.	.
cord-019001-ralxw4ad	47	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	47	2	vascular	vascular	JJ
cord-019001-ralxw4ad	47	3	resistance	resistance	NN
cord-019001-ralxw4ad	47	4	changes	change	NNS
cord-019001-ralxw4ad	47	5	throughout	throughout	IN
cord-019001-ralxw4ad	47	6	gestation	gestation	NN
cord-019001-ralxw4ad	47	7	and	and	CC
cord-019001-ralxw4ad	47	8	after	after	IN
cord-019001-ralxw4ad	47	9	birth	birth	NN
cord-019001-ralxw4ad	47	10	.	.	.
cord-019001-ralxw4ad	48	1	The	the	DT
cord-019001-ralxw4ad	48	2	resistance	resistance	NN
cord-019001-ralxw4ad	48	3	of	of	IN
cord-019001-ralxw4ad	48	4	the	the	DT
cord-019001-ralxw4ad	48	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	48	6	circulation	circulation	NN
cord-019001-ralxw4ad	48	7	at	at	IN
cord-019001-ralxw4ad	48	8	any	any	DT
cord-019001-ralxw4ad	48	9	one	one	CD
cord-019001-ralxw4ad	48	10	time	time	NN
cord-019001-ralxw4ad	48	11	is	be	VBZ
cord-019001-ralxw4ad	48	12	related	relate	VBN
cord-019001-ralxw4ad	48	13	to	to	IN
cord-019001-ralxw4ad	48	14	several	several	JJ
cord-019001-ralxw4ad	48	15	factors	factor	NNS
cord-019001-ralxw4ad	48	16	and	and	CC
cord-019001-ralxw4ad	48	17	can	can	MD
cord-019001-ralxw4ad	48	18	be	be	VB
cord-019001-ralxw4ad	48	19	estimated	estimate	VBN
cord-019001-ralxw4ad	48	20	by	by	IN
cord-019001-ralxw4ad	48	21	applying	apply	VBG
cord-019001-ralxw4ad	48	22	the	the	DT
cord-019001-ralxw4ad	48	23	resistance	resistance	NN
cord-019001-ralxw4ad	48	24	equation	equation	NN
cord-019001-ralxw4ad	48	25	and	and	CC
cord-019001-ralxw4ad	48	26	the	the	DT
cord-019001-ralxw4ad	48	27	Poiseuille	Poiseuille	NNP
cord-019001-ralxw4ad	48	28	-	-	HYPH
cord-019001-ralxw4ad	48	29	Hagen	Hagen	NNP
cord-019001-ralxw4ad	48	30	relationship	relationship	NN
cord-019001-ralxw4ad	48	31	[	[	-LRB-
cord-019001-ralxw4ad	48	32	76	76	CD
cord-019001-ralxw4ad	48	33	]	]	-RRB-
cord-019001-ralxw4ad	48	34	.	.	.
cord-019001-ralxw4ad	49	1	The	the	DT
cord-019001-ralxw4ad	49	2	resistance	resistance	NN
cord-019001-ralxw4ad	49	3	equation	equation	NN
cord-019001-ralxw4ad	49	4	(	(	-LRB-
cord-019001-ralxw4ad	49	5	the	the	DT
cord-019001-ralxw4ad	49	6	hydraulic	hydraulic	JJ
cord-019001-ralxw4ad	49	7	equivalent	equivalent	NN
cord-019001-ralxw4ad	49	8	of	of	IN
cord-019001-ralxw4ad	49	9	Ohm	Ohm	NNP
cord-019001-ralxw4ad	49	10	's	's	POS
cord-019001-ralxw4ad	49	11	law	law	NN
cord-019001-ralxw4ad	49	12	)	)	-RRB-
cord-019001-ralxw4ad	49	13	states	state	VBZ
cord-019001-ralxw4ad	49	14	that	that	IN
cord-019001-ralxw4ad	49	15	the	the	DT
cord-019001-ralxw4ad	49	16	resistance	resistance	NN
cord-019001-ralxw4ad	49	17	to	to	IN
cord-019001-ralxw4ad	49	18	fl	fl	NNP
cord-019001-ralxw4ad	49	19	ow	ow	NN
cord-019001-ralxw4ad	49	20	between	between	IN
cord-019001-ralxw4ad	49	21	two	two	CD
cord-019001-ralxw4ad	49	22	points	point	NNS
cord-019001-ralxw4ad	49	23	along	along	IN
cord-019001-ralxw4ad	49	24	a	a	DT
cord-019001-ralxw4ad	49	25	tube	tube	NN
cord-019001-ralxw4ad	49	26	equals	equal	VBZ
cord-019001-ralxw4ad	49	27	the	the	DT
cord-019001-ralxw4ad	49	28	decrease	decrease	NN
cord-019001-ralxw4ad	49	29	in	in	IN
cord-019001-ralxw4ad	49	30	pressure	pressure	NN
cord-019001-ralxw4ad	49	31	between	between	IN
cord-019001-ralxw4ad	49	32	the	the	DT
cord-019001-ralxw4ad	49	33	two	two	CD
cord-019001-ralxw4ad	49	34	points	point	NNS
cord-019001-ralxw4ad	49	35	divided	divide	VBN
cord-019001-ralxw4ad	49	36	by	by	IN
cord-019001-ralxw4ad	49	37	the	the	DT
cord-019001-ralxw4ad	49	38	fl	fl	NNP
cord-019001-ralxw4ad	49	39	ow	ow	NNP
cord-019001-ralxw4ad	49	40	[	[	-LRB-
cord-019001-ralxw4ad	49	41	77	77	CD
cord-019001-ralxw4ad	49	42	,	,	,
cord-019001-ralxw4ad	49	43	78	78	CD
cord-019001-ralxw4ad	49	44	]	]	-RRB-
cord-019001-ralxw4ad	49	45	.	.	.
cord-019001-ralxw4ad	50	1	For	for	IN
cord-019001-ralxw4ad	50	2	the	the	DT
cord-019001-ralxw4ad	50	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	50	4	vascular	vascular	JJ
cord-019001-ralxw4ad	50	5	bed	bed	NN
cord-019001-ralxw4ad	50	6	,	,	,
cord-019001-ralxw4ad	50	7	where	where	WRB
cord-019001-ralxw4ad	50	8	Rp	Rp	NNP
cord-019001-ralxw4ad	50	9	is	be	VBZ
cord-019001-ralxw4ad	50	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	50	11	vascular	vascular	JJ
cord-019001-ralxw4ad	50	12	resistance	resistance	NN
cord-019001-ralxw4ad	50	13	and	and	CC
cord-019001-ralxw4ad	50	14	Qp	Qp	NNP
cord-019001-ralxw4ad	50	15	is	be	VBZ
cord-019001-ralxw4ad	50	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	50	17	blood	blood	NN
cord-019001-ralxw4ad	50	18	fl	fl	NNP
cord-019001-ralxw4ad	50	19	ow	ow	NNP
cord-019001-ralxw4ad	50	20	,	,	,
cord-019001-ralxw4ad	50	21	the	the	DT
cord-019001-ralxw4ad	50	22	decrease	decrease	NN
cord-019001-ralxw4ad	50	23	in	in	IN
cord-019001-ralxw4ad	50	24	mean	mean	JJ
cord-019001-ralxw4ad	50	25	pressure	pressure	NN
cord-019001-ralxw4ad	50	26	is	be	VBZ
cord-019001-ralxw4ad	50	27	from	from	IN
cord-019001-ralxw4ad	50	28	the	the	DT
cord-019001-ralxw4ad	50	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	50	30	artery	artery	NN
cord-019001-ralxw4ad	50	31	(	(	-LRB-
cord-019001-ralxw4ad	50	32	Ppa	Ppa	NNP
cord-019001-ralxw4ad	50	33	)	)	-RRB-
cord-019001-ralxw4ad	50	34	to	to	IN
cord-019001-ralxw4ad	50	35	the	the	DT
cord-019001-ralxw4ad	50	36	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	50	37	vein	vein	NN
cord-019001-ralxw4ad	50	38	(	(	-LRB-
cord-019001-ralxw4ad	50	39	Ppv	Ppv	NNP
cord-019001-ralxw4ad	50	40	)	)	-RRB-
cord-019001-ralxw4ad	50	41	or	or	CC
cord-019001-ralxw4ad	50	42	left	leave	VBD
cord-019001-ralxw4ad	50	43	atrium	atrium	NN
cord-019001-ralxw4ad	50	44	,	,	,
cord-019001-ralxw4ad	50	45	where	where	WRB
cord-019001-ralxw4ad	50	46	la	la	NNP
cord-019001-ralxw4ad	50	47	is	be	VBZ
cord-019001-ralxw4ad	50	48	mean	mean	JJ
cord-019001-ralxw4ad	50	49	left	left	JJ
cord-019001-ralxw4ad	50	50	atrial	atrial	JJ
cord-019001-ralxw4ad	50	51	pressure	pressure	NN
cord-019001-ralxw4ad	50	52	:	:	:
cord-019001-ralxw4ad	51	1	Rp	rp	NN
cord-019001-ralxw4ad	51	2	=	=	NFP
cord-019001-ralxw4ad	52	1	[	[	-LRB-
cord-019001-ralxw4ad	53	1	Ppa	Ppa	NNP
cord-019001-ralxw4ad	53	2	−	−	NNP
cord-019001-ralxw4ad	53	3	Ppv	Ppv	NNP
cord-019001-ralxw4ad	53	4	or	or	CC
cord-019001-ralxw4ad	53	5	la	la	NNP
cord-019001-ralxw4ad	54	1	(	(	-LRB-
cord-019001-ralxw4ad	54	2	mean)]/Qp	mean)]/qp	NN
cord-019001-ralxw4ad	55	1	Therefore	therefore	RB
cord-019001-ralxw4ad	55	2	,	,	,
cord-019001-ralxw4ad	55	3	the	the	DT
cord-019001-ralxw4ad	55	4	calculated	calculate	VBN
cord-019001-ralxw4ad	55	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	55	6	vascular	vascular	JJ
cord-019001-ralxw4ad	55	7	resistance	resistance	NN
cord-019001-ralxw4ad	55	8	increases	increase	NNS
cord-019001-ralxw4ad	55	9	when	when	WRB
cord-019001-ralxw4ad	55	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	55	11	arterial	arterial	JJ
cord-019001-ralxw4ad	55	12	pressure	pressure	NN
cord-019001-ralxw4ad	55	13	increases	increase	NNS
cord-019001-ralxw4ad	55	14	or	or	CC
cord-019001-ralxw4ad	55	15	when	when	WRB
cord-019001-ralxw4ad	55	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	55	17	blood	blood	NN
cord-019001-ralxw4ad	55	18	fl	fl	NNP
cord-019001-ralxw4ad	55	19	ow	ow	NNP
cord-019001-ralxw4ad	55	20	decreases	decrease	VBZ
cord-019001-ralxw4ad	55	21	.	.	.
cord-019001-ralxw4ad	56	1	Changes	change	NNS
cord-019001-ralxw4ad	56	2	in	in	IN
cord-019001-ralxw4ad	56	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	56	4	venous	venous	JJ
cord-019001-ralxw4ad	56	5	pressure	pressure	NN
cord-019001-ralxw4ad	56	6	or	or	CC
cord-019001-ralxw4ad	56	7	mean	mean	VB
cord-019001-ralxw4ad	56	8	left	left	JJ
cord-019001-ralxw4ad	56	9	atrial	atrial	JJ
cord-019001-ralxw4ad	56	10	pressure	pressure	NN
cord-019001-ralxw4ad	56	11	are	be	VBP
cord-019001-ralxw4ad	56	12	somewhat	somewhat	RB
cord-019001-ralxw4ad	56	13	more	more	RBR
cord-019001-ralxw4ad	56	14	complicated	complicated	JJ
cord-019001-ralxw4ad	56	15	.	.	.
cord-019001-ralxw4ad	57	1	In	in	IN
cord-019001-ralxw4ad	57	2	isolation	isolation	NN
cord-019001-ralxw4ad	57	3	,	,	,
cord-019001-ralxw4ad	57	4	increases	increase	NNS
cord-019001-ralxw4ad	57	5	in	in	IN
cord-019001-ralxw4ad	57	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	57	7	venous	venous	JJ
cord-019001-ralxw4ad	57	8	pressure	pressure	NN
cord-019001-ralxw4ad	57	9	and	and	CC
cord-019001-ralxw4ad	57	10	left	left	JJ
cord-019001-ralxw4ad	57	11	atrial	atrial	JJ
cord-019001-ralxw4ad	57	12	pressure	pressure	NN
cord-019001-ralxw4ad	57	13	would	would	MD
cord-019001-ralxw4ad	57	14	decrease	decrease	VB
cord-019001-ralxw4ad	57	15	the	the	DT
cord-019001-ralxw4ad	57	16	calculated	calculate	VBN
cord-019001-ralxw4ad	57	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	57	18	vascular	vascular	JJ
cord-019001-ralxw4ad	57	19	resistance	resistance	NN
cord-019001-ralxw4ad	57	20	.	.	.
cord-019001-ralxw4ad	58	1	However	however	RB
cord-019001-ralxw4ad	58	2	,	,	,
cord-019001-ralxw4ad	58	3	increases	increase	NNS
cord-019001-ralxw4ad	58	4	in	in	IN
cord-019001-ralxw4ad	58	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	58	6	venous	venous	JJ
cord-019001-ralxw4ad	58	7	pressure	pressure	NN
cord-019001-ralxw4ad	58	8	are	be	VBP
cord-019001-ralxw4ad	58	9	generally	generally	RB
cord-019001-ralxw4ad	58	10	accompanied	accompany	VBN
cord-019001-ralxw4ad	58	11	by	by	IN
cord-019001-ralxw4ad	58	12	a	a	DT
cord-019001-ralxw4ad	58	13	greater	great	JJR
cord-019001-ralxw4ad	58	14	increase	increase	NN
cord-019001-ralxw4ad	58	15	in	in	IN
cord-019001-ralxw4ad	58	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	58	17	arterial	arterial	JJ
cord-019001-ralxw4ad	58	18	pressure	pressure	NN
cord-019001-ralxw4ad	58	19	(	(	-LRB-
cord-019001-ralxw4ad	58	20	which	which	WDT
cord-019001-ralxw4ad	58	21	maintains	maintain	VBZ
cord-019001-ralxw4ad	58	22	driving	drive	VBG
cord-019001-ralxw4ad	58	23	pressure	pressure	NN
cord-019001-ralxw4ad	58	24	)	)	-RRB-
cord-019001-ralxw4ad	58	25	,	,	,
cord-019001-ralxw4ad	58	26	resulting	result	VBG
cord-019001-ralxw4ad	58	27	in	in	IN
cord-019001-ralxw4ad	58	28	an	an	DT
cord-019001-ralxw4ad	58	29	increase	increase	NN
cord-019001-ralxw4ad	58	30	in	in	IN
cord-019001-ralxw4ad	58	31	the	the	DT
cord-019001-ralxw4ad	58	32	calculated	calculate	VBN
cord-019001-ralxw4ad	58	33	resistance	resistance	NN
cord-019001-ralxw4ad	58	34	across	across	IN
cord-019001-ralxw4ad	58	35	the	the	DT
cord-019001-ralxw4ad	58	36	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	58	37	vascular	vascular	JJ
cord-019001-ralxw4ad	58	38	bed	bed	NN
cord-019001-ralxw4ad	58	39	.	.	.
cord-019001-ralxw4ad	59	1	Furthermore	furthermore	RB
cord-019001-ralxw4ad	59	2	,	,	,
cord-019001-ralxw4ad	59	3	changes	change	NNS
cord-019001-ralxw4ad	59	4	in	in	IN
cord-019001-ralxw4ad	59	5	left	left	JJ
cord-019001-ralxw4ad	59	6	atrial	atrial	JJ
cord-019001-ralxw4ad	59	7	pressure	pressure	NN
cord-019001-ralxw4ad	59	8	,	,	,
cord-019001-ralxw4ad	59	9	which	which	WDT
cord-019001-ralxw4ad	59	10	occur	occur	VBP
cord-019001-ralxw4ad	59	11	independent	independent	JJ
cord-019001-ralxw4ad	59	12	of	of	IN
cord-019001-ralxw4ad	59	13	alterations	alteration	NNS
cord-019001-ralxw4ad	59	14	in	in	IN
cord-019001-ralxw4ad	59	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	59	16	vascular	vascular	JJ
cord-019001-ralxw4ad	59	17	resistance	resistance	NN
cord-019001-ralxw4ad	59	18	,	,	,
cord-019001-ralxw4ad	59	19	must	must	MD
cord-019001-ralxw4ad	59	20	be	be	VB
cord-019001-ralxw4ad	59	21	considered	consider	VBN
cord-019001-ralxw4ad	59	22	.	.	.
cord-019001-ralxw4ad	60	1	For	for	IN
cord-019001-ralxw4ad	60	2	example	example	NN
cord-019001-ralxw4ad	60	3	,	,	,
cord-019001-ralxw4ad	60	4	large	large	JJ
cord-019001-ralxw4ad	60	5	intracardiac	intracardiac	NN
cord-019001-ralxw4ad	60	6	shunts	shunt	NNS
cord-019001-ralxw4ad	60	7	(	(	-LRB-
cord-019001-ralxw4ad	60	8	e.g.	e.g.	RB
cord-019001-ralxw4ad	60	9	,	,	,
cord-019001-ralxw4ad	60	10	ventricular	ventricular	JJ
cord-019001-ralxw4ad	60	11	septal	septal	JJ
cord-019001-ralxw4ad	60	12	defect	defect	NN
cord-019001-ralxw4ad	60	13	)	)	-RRB-
cord-019001-ralxw4ad	60	14	may	may	MD
cord-019001-ralxw4ad	60	15	result	result	VB
cord-019001-ralxw4ad	60	16	in	in	IN
cord-019001-ralxw4ad	60	17	congestive	congestive	JJ
cord-019001-ralxw4ad	60	18	heart	heart	NN
cord-019001-ralxw4ad	60	19	failure	failure	NN
cord-019001-ralxw4ad	60	20	with	with	IN
cord-019001-ralxw4ad	60	21	an	an	DT
cord-019001-ralxw4ad	60	22	elevation	elevation	NN
cord-019001-ralxw4ad	60	23	in	in	IN
cord-019001-ralxw4ad	60	24	left	left	JJ
cord-019001-ralxw4ad	60	25	atrial	atrial	JJ
cord-019001-ralxw4ad	60	26	pressure	pressure	NN
cord-019001-ralxw4ad	60	27	.	.	.
cord-019001-ralxw4ad	61	1	Closure	closure	NN
cord-019001-ralxw4ad	61	2	of	of	IN
cord-019001-ralxw4ad	61	3	the	the	DT
cord-019001-ralxw4ad	61	4	ventricular	ventricular	JJ
cord-019001-ralxw4ad	61	5	septal	septal	JJ
cord-019001-ralxw4ad	61	6	defect	defect	NN
cord-019001-ralxw4ad	61	7	may	may	MD
cord-019001-ralxw4ad	61	8	acutely	acutely	RB
cord-019001-ralxw4ad	61	9	decrease	decrease	VB
cord-019001-ralxw4ad	61	10	left	leave	VBN
cord-019001-ralxw4ad	61	11	atrial	atrial	JJ
cord-019001-ralxw4ad	61	12	pressure	pressure	NN
cord-019001-ralxw4ad	61	13	,	,	,
cord-019001-ralxw4ad	61	14	resulting	result	VBG
cord-019001-ralxw4ad	61	15	in	in	IN
cord-019001-ralxw4ad	61	16	an	an	DT
cord-019001-ralxw4ad	61	17	elevation	elevation	NN
cord-019001-ralxw4ad	61	18	in	in	IN
cord-019001-ralxw4ad	61	19	the	the	DT
cord-019001-ralxw4ad	61	20	calculated	calculate	VBN
cord-019001-ralxw4ad	61	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	61	22	vascular	vascular	JJ
cord-019001-ralxw4ad	61	23	resistance	resistance	NN
cord-019001-ralxw4ad	61	24	(	(	-LRB-
cord-019001-ralxw4ad	61	25	provided	provide	VBN
cord-019001-ralxw4ad	61	26	that	that	IN
cord-019001-ralxw4ad	61	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	61	28	arterial	arterial	JJ
cord-019001-ralxw4ad	61	29	pressure	pressure	NN
cord-019001-ralxw4ad	61	30	does	do	VBZ
cord-019001-ralxw4ad	61	31	not	not	RB
cord-019001-ralxw4ad	61	32	decrease	decrease	VB
cord-019001-ralxw4ad	61	33	to	to	IN
cord-019001-ralxw4ad	61	34	the	the	DT
cord-019001-ralxw4ad	61	35	same	same	JJ
cord-019001-ralxw4ad	61	36	extent	extent	NN
cord-019001-ralxw4ad	61	37	)	)	-RRB-
cord-019001-ralxw4ad	61	38	,	,	,
cord-019001-ralxw4ad	61	39	when	when	WRB
cord-019001-ralxw4ad	61	40	in	in	IN
cord-019001-ralxw4ad	61	41	fact	fact	NN
cord-019001-ralxw4ad	61	42	no	no	DT
cord-019001-ralxw4ad	61	43	change	change	NN
cord-019001-ralxw4ad	61	44	in	in	IN
cord-019001-ralxw4ad	61	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	61	46	vascular	vascular	JJ
cord-019001-ralxw4ad	61	47	tone	tone	NN
cord-019001-ralxw4ad	61	48	has	have	VBZ
cord-019001-ralxw4ad	61	49	occurred	occur	VBN
cord-019001-ralxw4ad	61	50	[	[	-LRB-
cord-019001-ralxw4ad	61	51	79	79	CD
cord-019001-ralxw4ad	61	52	]	]	-RRB-
cord-019001-ralxw4ad	61	53	.	.	.
cord-019001-ralxw4ad	62	1	Other	other	JJ
cord-019001-ralxw4ad	62	2	factors	factor	NNS
cord-019001-ralxw4ad	62	3	that	that	WDT
cord-019001-ralxw4ad	62	4	affect	affect	VBP
cord-019001-ralxw4ad	62	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	62	6	vascular	vascular	JJ
cord-019001-ralxw4ad	62	7	resistance	resistance	NN
cord-019001-ralxw4ad	62	8	can	can	MD
cord-019001-ralxw4ad	62	9	be	be	VB
cord-019001-ralxw4ad	62	10	defi	defi	NNP
cord-019001-ralxw4ad	62	11	ned	ned	NNP
cord-019001-ralxw4ad	62	12	by	by	IN
cord-019001-ralxw4ad	62	13	applying	apply	VBG
cord-019001-ralxw4ad	62	14	a	a	DT
cord-019001-ralxw4ad	62	15	modifi	modifi	JJ
cord-019001-ralxw4ad	62	16	cation	cation	NN
cord-019001-ralxw4ad	62	17	of	of	IN
cord-019001-ralxw4ad	62	18	the	the	DT
cord-019001-ralxw4ad	62	19	Poiseuille	Poiseuille	NNP
cord-019001-ralxw4ad	62	20	-	-	HYPH
cord-019001-ralxw4ad	62	21	Hagen	Hagen	NNP
cord-019001-ralxw4ad	62	22	relationship	relationship	NN
cord-019001-ralxw4ad	62	23	,	,	,
cord-019001-ralxw4ad	62	24	which	which	WDT
cord-019001-ralxw4ad	62	25	describes	describe	VBZ
cord-019001-ralxw4ad	62	26	the	the	DT
cord-019001-ralxw4ad	62	27	resistance	resistance	NN
cord-019001-ralxw4ad	62	28	(	(	-LRB-
cord-019001-ralxw4ad	62	29	R	r	NN
cord-019001-ralxw4ad	62	30	)	)	-RRB-
cord-019001-ralxw4ad	62	31	to	to	IN
cord-019001-ralxw4ad	62	32	fl	fl	NNP
cord-019001-ralxw4ad	62	33	ow	ow	UH
cord-019001-ralxw4ad	62	34	of	of	IN
cord-019001-ralxw4ad	62	35	a	a	DT
cord-019001-ralxw4ad	62	36	Newtonian	Newtonian	NNP
cord-019001-ralxw4ad	62	37	fl	fl	NNP
cord-019001-ralxw4ad	62	38	uid	uid	NN
cord-019001-ralxw4ad	62	39	through	through	IN
cord-019001-ralxw4ad	62	40	a	a	DT
cord-019001-ralxw4ad	62	41	system	system	NN
cord-019001-ralxw4ad	62	42	of	of	IN
cord-019001-ralxw4ad	62	43	round	round	JJ
cord-019001-ralxw4ad	62	44	,	,	,
cord-019001-ralxw4ad	62	45	straight	straight	JJ
cord-019001-ralxw4ad	62	46	glass	glass	NN
cord-019001-ralxw4ad	62	47	tubes	tube	NNS
cord-019001-ralxw4ad	62	48	of	of	IN
cord-019001-ralxw4ad	62	49	constant	constant	JJ
cord-019001-ralxw4ad	62	50	cross	cross	NNP
cord-019001-ralxw4ad	62	51	sectional	sectional	JJ
cord-019001-ralxw4ad	62	52	area	area	NN
cord-019001-ralxw4ad	62	53	:	:	:
cord-019001-ralxw4ad	62	54	where	where	WRB
cord-019001-ralxw4ad	62	55	l	l	NNP
cord-019001-ralxw4ad	62	56	is	be	VBZ
cord-019001-ralxw4ad	62	57	length	length	NN
cord-019001-ralxw4ad	62	58	of	of	IN
cord-019001-ralxw4ad	62	59	the	the	DT
cord-019001-ralxw4ad	62	60	system	system	NN
cord-019001-ralxw4ad	62	61	of	of	IN
cord-019001-ralxw4ad	62	62	vessels	vessel	NNS
cord-019001-ralxw4ad	62	63	,	,	,
cord-019001-ralxw4ad	62	64	n	n	NNP
cord-019001-ralxw4ad	62	65	is	be	VBZ
cord-019001-ralxw4ad	62	66	vessel	vessel	NN
cord-019001-ralxw4ad	62	67	number	number	NN
cord-019001-ralxw4ad	62	68	,	,	,
cord-019001-ralxw4ad	62	69	r	r	NNP
cord-019001-ralxw4ad	62	70	is	be	VBZ
cord-019001-ralxw4ad	62	71	the	the	DT
cord-019001-ralxw4ad	62	72	internal	internal	JJ
cord-019001-ralxw4ad	62	73	radius	radius	NN
cord-019001-ralxw4ad	62	74	of	of	IN
cord-019001-ralxw4ad	62	75	the	the	DT
cord-019001-ralxw4ad	62	76	system	system	NN
cord-019001-ralxw4ad	62	77	of	of	IN
cord-019001-ralxw4ad	62	78	vessels	vessel	NNS
cord-019001-ralxw4ad	62	79	,	,	,
cord-019001-ralxw4ad	62	80	and	and	CC
cord-019001-ralxw4ad	62	81	η	η	NN
cord-019001-ralxw4ad	62	82	is	be	VBZ
cord-019001-ralxw4ad	62	83	the	the	DT
cord-019001-ralxw4ad	62	84	viscosity	viscosity	NN
cord-019001-ralxw4ad	62	85	of	of	IN
cord-019001-ralxw4ad	62	86	the	the	DT
cord-019001-ralxw4ad	62	87	fl	fl	NNP
cord-019001-ralxw4ad	62	88	uid	uid	NN
cord-019001-ralxw4ad	62	89	.	.	.
cord-019001-ralxw4ad	63	1	According	accord	VBG
cord-019001-ralxw4ad	63	2	to	to	IN
cord-019001-ralxw4ad	63	3	this	this	DT
cord-019001-ralxw4ad	63	4	relationship	relationship	NN
cord-019001-ralxw4ad	63	5	,	,	,
cord-019001-ralxw4ad	63	6	increasing	increase	VBG
cord-019001-ralxw4ad	63	7	the	the	DT
cord-019001-ralxw4ad	63	8	viscosity	viscosity	NN
cord-019001-ralxw4ad	63	9	of	of	IN
cord-019001-ralxw4ad	63	10	blood	blood	NN
cord-019001-ralxw4ad	63	11	perfusing	perfuse	VBG
cord-019001-ralxw4ad	63	12	the	the	DT
cord-019001-ralxw4ad	63	13	lungs	lung	NNS
cord-019001-ralxw4ad	63	14	or	or	CC
cord-019001-ralxw4ad	63	15	decreasing	decrease	VBG
cord-019001-ralxw4ad	63	16	the	the	DT
cord-019001-ralxw4ad	63	17	radius	radius	NN
cord-019001-ralxw4ad	63	18	or	or	CC
cord-019001-ralxw4ad	63	19	crosssectional	crosssectional	JJ
cord-019001-ralxw4ad	63	20	area	area	NN
cord-019001-ralxw4ad	63	21	(	(	-LRB-
cord-019001-ralxw4ad	63	22	πr	πr	VBZ
cord-019001-ralxw4ad	63	23	4	4	CD
cord-019001-ralxw4ad	63	24	)	)	-RRB-
cord-019001-ralxw4ad	63	25	of	of	IN
cord-019001-ralxw4ad	63	26	the	the	DT
cord-019001-ralxw4ad	63	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	63	28	vascular	vascular	JJ
cord-019001-ralxw4ad	63	29	bed	bed	NN
cord-019001-ralxw4ad	63	30	increases	increase	VBZ
cord-019001-ralxw4ad	63	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	63	32	vascular	vascular	JJ
cord-019001-ralxw4ad	63	33	resistance	resistance	NN
cord-019001-ralxw4ad	63	34	.	.	.
cord-019001-ralxw4ad	64	1	Because	because	IN
cord-019001-ralxw4ad	64	2	the	the	DT
cord-019001-ralxw4ad	64	3	above	above	JJ
cord-019001-ralxw4ad	64	4	equations	equation	NNS
cord-019001-ralxw4ad	64	5	describe	describe	VBP
cord-019001-ralxw4ad	64	6	steady	steady	JJ
cord-019001-ralxw4ad	64	7	,	,	,
cord-019001-ralxw4ad	64	8	laminar	laminar	NNP
cord-019001-ralxw4ad	64	9	fl	fl	NNP
cord-019001-ralxw4ad	64	10	ow	ow	NN
cord-019001-ralxw4ad	64	11	of	of	IN
cord-019001-ralxw4ad	64	12	a	a	DT
cord-019001-ralxw4ad	64	13	Newtonian	Newtonian	NNP
cord-019001-ralxw4ad	64	14	fl	fl	NNP
cord-019001-ralxw4ad	64	15	uid	uid	NN
cord-019001-ralxw4ad	64	16	in	in	IN
cord-019001-ralxw4ad	64	17	rigid	rigid	JJ
cord-019001-ralxw4ad	64	18	,	,	,
cord-019001-ralxw4ad	64	19	glass	glass	NN
cord-019001-ralxw4ad	64	20	tubes	tube	NNS
cord-019001-ralxw4ad	64	21	,	,	,
cord-019001-ralxw4ad	64	22	differences	difference	NNS
cord-019001-ralxw4ad	64	23	between	between	IN
cord-019001-ralxw4ad	64	24	physical	physical	JJ
cord-019001-ralxw4ad	64	25	and	and	CC
cord-019001-ralxw4ad	64	26	biologic	biologic	JJ
cord-019001-ralxw4ad	64	27	systems	system	NNS
cord-019001-ralxw4ad	64	28	should	should	MD
cord-019001-ralxw4ad	64	29	be	be	VB
cord-019001-ralxw4ad	64	30	considered	consider	VBN
cord-019001-ralxw4ad	64	31	.	.	.
cord-019001-ralxw4ad	65	1	First	first	RB
cord-019001-ralxw4ad	65	2	,	,	,
cord-019001-ralxw4ad	65	3	blood	blood	NN
cord-019001-ralxw4ad	65	4	is	be	VBZ
cord-019001-ralxw4ad	65	5	not	not	RB
cord-019001-ralxw4ad	65	6	a	a	DT
cord-019001-ralxw4ad	65	7	Newtonian	Newtonian	NNP
cord-019001-ralxw4ad	65	8	fl	fl	NNP
cord-019001-ralxw4ad	65	9	uid	uid	NN
cord-019001-ralxw4ad	65	10	.	.	.
cord-019001-ralxw4ad	66	1	However	however	RB
cord-019001-ralxw4ad	66	2	,	,	,
cord-019001-ralxw4ad	66	3	this	this	DT
cord-019001-ralxw4ad	66	4	is	be	VBZ
cord-019001-ralxw4ad	66	5	probably	probably	RB
cord-019001-ralxw4ad	66	6	of	of	IN
cord-019001-ralxw4ad	66	7	little	little	JJ
cord-019001-ralxw4ad	66	8	importance	importance	NN
cord-019001-ralxw4ad	66	9	at	at	IN
cord-019001-ralxw4ad	66	10	normal	normal	JJ
cord-019001-ralxw4ad	66	11	hematocrit	hematocrit	NN
cord-019001-ralxw4ad	66	12	levels	level	NNS
cord-019001-ralxw4ad	66	13	[	[	-LRB-
cord-019001-ralxw4ad	66	14	80	80	CD
cord-019001-ralxw4ad	66	15	]	]	-RRB-
cord-019001-ralxw4ad	66	16	.	.	.
cord-019001-ralxw4ad	67	1	The	the	DT
cord-019001-ralxw4ad	67	2	viscosity	viscosity	NN
cord-019001-ralxw4ad	67	3	of	of	IN
cord-019001-ralxw4ad	67	4	blood	blood	NN
cord-019001-ralxw4ad	67	5	is	be	VBZ
cord-019001-ralxw4ad	67	6	related	relate	VBN
cord-019001-ralxw4ad	67	7	to	to	IN
cord-019001-ralxw4ad	67	8	red	red	JJ
cord-019001-ralxw4ad	67	9	cell	cell	NN
cord-019001-ralxw4ad	67	10	number	number	NN
cord-019001-ralxw4ad	67	11	,	,	,
cord-019001-ralxw4ad	67	12	fi	fi	NNP
cord-019001-ralxw4ad	67	13	brinogen	brinogen	NNP
cord-019001-ralxw4ad	67	14	concentration	concentration	NN
cord-019001-ralxw4ad	67	15	,	,	,
cord-019001-ralxw4ad	67	16	and	and	CC
cord-019001-ralxw4ad	67	17	red	red	JJ
cord-019001-ralxw4ad	67	18	cell	cell	NN
cord-019001-ralxw4ad	67	19	deformability	deformability	NN
cord-019001-ralxw4ad	67	20	.	.	.
cord-019001-ralxw4ad	68	1	An	an	DT
cord-019001-ralxw4ad	68	2	increased	increase	VBN
cord-019001-ralxw4ad	68	3	hematocrit	hematocrit	NN
cord-019001-ralxw4ad	68	4	(	(	-LRB-
cord-019001-ralxw4ad	68	5	secondary	secondary	JJ
cord-019001-ralxw4ad	68	6	to	to	IN
cord-019001-ralxw4ad	68	7	fetal	fetal	JJ
cord-019001-ralxw4ad	68	8	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	68	9	,	,	,
cord-019001-ralxw4ad	68	10	twin	twin	NN
cord-019001-ralxw4ad	68	11	-	-	HYPH
cord-019001-ralxw4ad	68	12	to	to	IN
cord-019001-ralxw4ad	68	13	-	-	HYPH
cord-019001-ralxw4ad	68	14	twin	twin	NN
cord-019001-ralxw4ad	68	15	transfusion	transfusion	NN
cord-019001-ralxw4ad	68	16	,	,	,
cord-019001-ralxw4ad	68	17	maternal	maternal	JJ
cord-019001-ralxw4ad	68	18	-	-	HYPH
cord-019001-ralxw4ad	68	19	to	to	IN
cord-019001-ralxw4ad	68	20	-	-	HYPH
cord-019001-ralxw4ad	68	21	fetal	fetal	JJ
cord-019001-ralxw4ad	68	22	transfusion	transfusion	NN
cord-019001-ralxw4ad	68	23	,	,	,
cord-019001-ralxw4ad	68	24	or	or	CC
cord-019001-ralxw4ad	68	25	delayed	delay	VBN
cord-019001-ralxw4ad	68	26	clamping	clamping	NN
cord-019001-ralxw4ad	68	27	of	of	IN
cord-019001-ralxw4ad	68	28	the	the	DT
cord-019001-ralxw4ad	68	29	umbilical	umbilical	JJ
cord-019001-ralxw4ad	68	30	cord	cord	NN
cord-019001-ralxw4ad	68	31	)	)	-RRB-
cord-019001-ralxw4ad	68	32	will	will	MD
cord-019001-ralxw4ad	68	33	increase	increase	VB
cord-019001-ralxw4ad	68	34	viscosity	viscosity	NN
cord-019001-ralxw4ad	68	35	[	[	-LRB-
cord-019001-ralxw4ad	68	36	80	80	CD
cord-019001-ralxw4ad	68	37	,	,	,
cord-019001-ralxw4ad	68	38	81	81	CD
cord-019001-ralxw4ad	68	39	]	]	-RRB-
cord-019001-ralxw4ad	68	40	as	as	IN
cord-019001-ralxw4ad	68	41	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	68	42	vascular	vascular	JJ
cord-019001-ralxw4ad	68	43	resistance	resistance	NN
cord-019001-ralxw4ad	68	44	increases	increase	NNS
cord-019001-ralxw4ad	68	45	logarithmically	logarithmically	RB
cord-019001-ralxw4ad	68	46	when	when	WRB
cord-019001-ralxw4ad	68	47	the	the	DT
cord-019001-ralxw4ad	68	48	hematocrit	hematocrit	NN
cord-019001-ralxw4ad	68	49	increases	increase	NNS
cord-019001-ralxw4ad	68	50	.	.	.
cord-019001-ralxw4ad	69	1	Second	second	JJ
cord-019001-ralxw4ad	69	2	,	,	,
cord-019001-ralxw4ad	69	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	69	4	vessels	vessel	NNS
cord-019001-ralxw4ad	69	5	are	be	VBP
cord-019001-ralxw4ad	69	6	not	not	RB
cord-019001-ralxw4ad	69	7	rigid	rigid	JJ
cord-019001-ralxw4ad	69	8	tubes	tube	NNS
cord-019001-ralxw4ad	69	9	.	.	.
cord-019001-ralxw4ad	70	1	Their	-PRON-	PRP$
cord-019001-ralxw4ad	70	2	walls	wall	NNS
cord-019001-ralxw4ad	70	3	are	be	VBP
cord-019001-ralxw4ad	70	4	deformable	deformable	JJ
cord-019001-ralxw4ad	70	5	,	,	,
cord-019001-ralxw4ad	70	6	and	and	CC
cord-019001-ralxw4ad	70	7	their	-PRON-	PRP$
cord-019001-ralxw4ad	70	8	size	size	NN
cord-019001-ralxw4ad	70	9	and	and	CC
cord-019001-ralxw4ad	70	10	shape	shape	NN
cord-019001-ralxw4ad	70	11	are	be	VBP
cord-019001-ralxw4ad	70	12	infl	infl	NN
cord-019001-ralxw4ad	70	13	uenced	uence	VBN
cord-019001-ralxw4ad	70	14	by	by	IN
cord-019001-ralxw4ad	70	15	transmural	transmural	NNP
cord-019001-ralxw4ad	70	16	pressure	pressure	NN
cord-019001-ralxw4ad	70	17	.	.	.
cord-019001-ralxw4ad	71	1	For	for	IN
cord-019001-ralxw4ad	71	2	example	example	NN
cord-019001-ralxw4ad	71	3	,	,	,
cord-019001-ralxw4ad	71	4	as	as	IN
cord-019001-ralxw4ad	71	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	71	6	blood	blood	NN
cord-019001-ralxw4ad	71	7	fl	fl	NNP
cord-019001-ralxw4ad	71	8	ow	ow	UH
cord-019001-ralxw4ad	71	9	or	or	CC
cord-019001-ralxw4ad	71	10	left	leave	VBD
cord-019001-ralxw4ad	71	11	atrial	atrial	JJ
cord-019001-ralxw4ad	71	12	pressure	pressure	NN
cord-019001-ralxw4ad	71	13	increases	increase	NNS
cord-019001-ralxw4ad	71	14	,	,	,
cord-019001-ralxw4ad	71	15	vessel	vessel	NN
cord-019001-ralxw4ad	71	16	diameter	diameter	NN
cord-019001-ralxw4ad	71	17	may	may	MD
cord-019001-ralxw4ad	71	18	change	change	VB
cord-019001-ralxw4ad	71	19	,	,	,
cord-019001-ralxw4ad	71	20	and/or	and/or	CC
cord-019001-ralxw4ad	71	21	the	the	DT
cord-019001-ralxw4ad	71	22	recruitment	recruitment	NN
cord-019001-ralxw4ad	71	23	of	of	IN
cord-019001-ralxw4ad	71	24	additional	additional	JJ
cord-019001-ralxw4ad	71	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	71	26	vessels	vessel	NNS
cord-019001-ralxw4ad	71	27	may	may	MD
cord-019001-ralxw4ad	71	28	occur	occur	VB
cord-019001-ralxw4ad	71	29	.	.	.
cord-019001-ralxw4ad	72	1	Therefore	therefore	RB
cord-019001-ralxw4ad	72	2	,	,	,
cord-019001-ralxw4ad	72	3	the	the	DT
cord-019001-ralxw4ad	72	4	fall	fall	NN
cord-019001-ralxw4ad	72	5	in	in	IN
cord-019001-ralxw4ad	72	6	calculated	calculate	VBN
cord-019001-ralxw4ad	72	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	72	8	vascular	vascular	JJ
cord-019001-ralxw4ad	72	9	resistance	resistance	NN
cord-019001-ralxw4ad	72	10	with	with	IN
cord-019001-ralxw4ad	72	11	increases	increase	NNS
cord-019001-ralxw4ad	72	12	in	in	IN
cord-019001-ralxw4ad	72	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	72	14	blood	blood	NN
cord-019001-ralxw4ad	72	15	fl	fl	NNP
cord-019001-ralxw4ad	72	16	ow	ow	NNP
cord-019001-ralxw4ad	72	17	is	be	VBZ
cord-019001-ralxw4ad	72	18	nonlinear	nonlinear	JJ
cord-019001-ralxw4ad	72	19	[	[	-LRB-
cord-019001-ralxw4ad	72	20	65	65	CD
cord-019001-ralxw4ad	72	21	,	,	,
cord-019001-ralxw4ad	72	22	82	82	CD
cord-019001-ralxw4ad	72	23	,	,	,
cord-019001-ralxw4ad	72	24	83	83	CD
cord-019001-ralxw4ad	72	25	]	]	-RRB-
cord-019001-ralxw4ad	72	26	.	.	.
cord-019001-ralxw4ad	73	1	Third	third	RB
cord-019001-ralxw4ad	73	2	,	,	,
cord-019001-ralxw4ad	73	3	blood	blood	NN
cord-019001-ralxw4ad	73	4	fl	fl	NNP
cord-019001-ralxw4ad	73	5	ow	ow	NN
cord-019001-ralxw4ad	73	6	through	through	IN
cord-019001-ralxw4ad	73	7	the	the	DT
cord-019001-ralxw4ad	73	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	73	9	circulation	circulation	NN
cord-019001-ralxw4ad	73	10	is	be	VBZ
cord-019001-ralxw4ad	73	11	pulsatile	pulsatile	JJ
cord-019001-ralxw4ad	73	12	,	,	,
cord-019001-ralxw4ad	73	13	not	not	RB
cord-019001-ralxw4ad	73	14	laminar	laminar	JJ
cord-019001-ralxw4ad	73	15	,	,	,
cord-019001-ralxw4ad	73	16	and	and	CC
cord-019001-ralxw4ad	73	17	the	the	DT
cord-019001-ralxw4ad	73	18	small	small	JJ
cord-019001-ralxw4ad	73	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	73	20	arteries	artery	NNS
cord-019001-ralxw4ad	73	21	are	be	VBP
cord-019001-ralxw4ad	73	22	branched	branch	VBN
cord-019001-ralxw4ad	73	23	,	,	,
cord-019001-ralxw4ad	73	24	curved	curved	JJ
cord-019001-ralxw4ad	73	25	,	,	,
cord-019001-ralxw4ad	73	26	and	and	CC
cord-019001-ralxw4ad	73	27	tapered	tapered	JJ
cord-019001-ralxw4ad	73	28	,	,	,
cord-019001-ralxw4ad	73	29	not	not	RB
cord-019001-ralxw4ad	73	30	smooth	smooth	VB
cord-019001-ralxw4ad	73	31	[	[	-LRB-
cord-019001-ralxw4ad	73	32	76	76	CD
cord-019001-ralxw4ad	73	33	]	]	-RRB-
cord-019001-ralxw4ad	73	34	.	.	.
cord-019001-ralxw4ad	74	1	In	in	IN
cord-019001-ralxw4ad	74	2	addition	addition	NN
cord-019001-ralxw4ad	74	3	,	,	,
cord-019001-ralxw4ad	74	4	the	the	DT
cord-019001-ralxw4ad	74	5	small	small	JJ
cord-019001-ralxw4ad	74	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	74	7	arteries	artery	NNS
cord-019001-ralxw4ad	74	8	are	be	VBP
cord-019001-ralxw4ad	74	9	in	in	IN
cord-019001-ralxw4ad	74	10	parallel	parallel	NN
cord-019001-ralxw4ad	74	11	,	,	,
cord-019001-ralxw4ad	74	12	and	and	CC
cord-019001-ralxw4ad	74	13	the	the	DT
cord-019001-ralxw4ad	74	14	radii	radii	NN
cord-019001-ralxw4ad	74	15	of	of	IN
cord-019001-ralxw4ad	74	16	these	these	DT
cord-019001-ralxw4ad	74	17	arteries	artery	NNS
cord-019001-ralxw4ad	74	18	may	may	MD
cord-019001-ralxw4ad	74	19	differ	differ	VB
cord-019001-ralxw4ad	74	20	in	in	IN
cord-019001-ralxw4ad	74	21	different	different	JJ
cord-019001-ralxw4ad	74	22	lung	lung	NN
cord-019001-ralxw4ad	74	23	zones	zone	NNS
cord-019001-ralxw4ad	74	24	.	.	.
cord-019001-ralxw4ad	75	1	Despite	despite	IN
cord-019001-ralxw4ad	75	2	these	these	DT
cord-019001-ralxw4ad	75	3	differences	difference	NNS
cord-019001-ralxw4ad	75	4	from	from	IN
cord-019001-ralxw4ad	75	5	physical	physical	JJ
cord-019001-ralxw4ad	75	6	models	model	NNS
cord-019001-ralxw4ad	75	7	,	,	,
cord-019001-ralxw4ad	75	8	the	the	DT
cord-019001-ralxw4ad	75	9	general	general	JJ
cord-019001-ralxw4ad	75	10	effects	effect	NNS
cord-019001-ralxw4ad	75	11	of	of	IN
cord-019001-ralxw4ad	75	12	changes	change	NNS
cord-019001-ralxw4ad	75	13	in	in	IN
cord-019001-ralxw4ad	75	14	physical	physical	JJ
cord-019001-ralxw4ad	75	15	factors	factor	NNS
cord-019001-ralxw4ad	75	16	,	,	,
cord-019001-ralxw4ad	75	17	such	such	JJ
cord-019001-ralxw4ad	75	18	as	as	IN
cord-019001-ralxw4ad	75	19	viscosity	viscosity	NN
cord-019001-ralxw4ad	75	20	and	and	CC
cord-019001-ralxw4ad	75	21	radius	radius	NN
cord-019001-ralxw4ad	75	22	,	,	,
cord-019001-ralxw4ad	75	23	do	do	VBP
cord-019001-ralxw4ad	75	24	apply	apply	VB
cord-019001-ralxw4ad	75	25	[	[	-LRB-
cord-019001-ralxw4ad	75	26	76	76	CD
cord-019001-ralxw4ad	75	27	]	]	-RRB-
cord-019001-ralxw4ad	75	28	[	[	-LRB-
cord-019001-ralxw4ad	75	29	77	77	CD
cord-019001-ralxw4ad	75	30	]	]	-RRB-
cord-019001-ralxw4ad	75	31	[	[	-LRB-
cord-019001-ralxw4ad	75	32	78	78	CD
cord-019001-ralxw4ad	75	33	]	]	-RRB-
cord-019001-ralxw4ad	75	34	.	.	.
cord-019001-ralxw4ad	76	1	In	in	IN
cord-019001-ralxw4ad	76	2	fact	fact	NN
cord-019001-ralxw4ad	76	3	,	,	,
cord-019001-ralxw4ad	76	4	a	a	DT
cord-019001-ralxw4ad	76	5	change	change	NN
cord-019001-ralxw4ad	76	6	in	in	IN
cord-019001-ralxw4ad	76	7	luminal	luminal	JJ
cord-019001-ralxw4ad	76	8	radius	radius	NN
cord-019001-ralxw4ad	76	9	is	be	VBZ
cord-019001-ralxw4ad	76	10	the	the	DT
cord-019001-ralxw4ad	76	11	major	major	JJ
cord-019001-ralxw4ad	76	12	factor	factor	NN
cord-019001-ralxw4ad	76	13	responsible	responsible	JJ
cord-019001-ralxw4ad	76	14	for	for	IN
cord-019001-ralxw4ad	76	15	maintaining	maintain	VBG
cord-019001-ralxw4ad	76	16	a	a	DT
cord-019001-ralxw4ad	76	17	high	high	JJ
cord-019001-ralxw4ad	76	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	76	19	vascular	vascular	JJ
cord-019001-ralxw4ad	76	20	resistance	resistance	NN
cord-019001-ralxw4ad	76	21	in	in	IN
cord-019001-ralxw4ad	76	22	the	the	DT
cord-019001-ralxw4ad	76	23	fetus	fetus	NN
cord-019001-ralxw4ad	76	24	.	.	.
cord-019001-ralxw4ad	77	1	Consideration	consideration	NN
cord-019001-ralxw4ad	77	2	of	of	IN
cord-019001-ralxw4ad	77	3	these	these	DT
cord-019001-ralxw4ad	77	4	factors	factor	NNS
cord-019001-ralxw4ad	77	5	,	,	,
cord-019001-ralxw4ad	77	6	particularly	particularly	RB
cord-019001-ralxw4ad	77	7	viscosity	viscosity	NN
cord-019001-ralxw4ad	77	8	and	and	CC
cord-019001-ralxw4ad	77	9	cross	cross	JJ
cord-019001-ralxw4ad	77	10	-	-	JJ
cord-019001-ralxw4ad	77	11	sectional	sectional	JJ
cord-019001-ralxw4ad	77	12	area	area	NN
cord-019001-ralxw4ad	77	13	of	of	IN
cord-019001-ralxw4ad	77	14	the	the	DT
cord-019001-ralxw4ad	77	15	vascular	vascular	JJ
cord-019001-ralxw4ad	77	16	bed	bed	NN
cord-019001-ralxw4ad	77	17	,	,	,
cord-019001-ralxw4ad	77	18	is	be	VBZ
cord-019001-ralxw4ad	77	19	important	important	JJ
cord-019001-ralxw4ad	77	20	in	in	IN
cord-019001-ralxw4ad	77	21	evaluating	evaluate	VBG
cord-019001-ralxw4ad	77	22	the	the	DT
cord-019001-ralxw4ad	77	23	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	77	24	of	of	IN
cord-019001-ralxw4ad	77	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	77	26	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	77	27	disorders	disorder	NNS
cord-019001-ralxw4ad	77	28	.	.	.
cord-019001-ralxw4ad	78	1	Finally	finally	RB
cord-019001-ralxw4ad	78	2	,	,	,
cord-019001-ralxw4ad	78	3	it	-PRON-	PRP
cord-019001-ralxw4ad	78	4	is	be	VBZ
cord-019001-ralxw4ad	78	5	important	important	JJ
cord-019001-ralxw4ad	78	6	to	to	TO
cord-019001-ralxw4ad	78	7	note	note	VB
cord-019001-ralxw4ad	78	8	the	the	DT
cord-019001-ralxw4ad	78	9	overall	overall	JJ
cord-019001-ralxw4ad	78	10	relationship	relationship	NN
cord-019001-ralxw4ad	78	11	between	between	IN
cord-019001-ralxw4ad	78	12	lung	lung	NN
cord-019001-ralxw4ad	78	13	volume	volume	NN
cord-019001-ralxw4ad	78	14	and	and	CC
cord-019001-ralxw4ad	78	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	78	16	vascular	vascular	JJ
cord-019001-ralxw4ad	78	17	resistance	resistance	NN
cord-019001-ralxw4ad	78	18	,	,	,
cord-019001-ralxw4ad	78	19	which	which	WDT
cord-019001-ralxw4ad	78	20	has	have	VBZ
cord-019001-ralxw4ad	78	21	been	be	VBN
cord-019001-ralxw4ad	78	22	described	describe	VBN
cord-019001-ralxw4ad	78	23	by	by	IN
cord-019001-ralxw4ad	78	24	several	several	JJ
cord-019001-ralxw4ad	78	25	investigators	investigator	NNS
cord-019001-ralxw4ad	78	26	[	[	-LRB-
cord-019001-ralxw4ad	78	27	84	84	CD
cord-019001-ralxw4ad	78	28	,	,	,
cord-019001-ralxw4ad	78	29	85	85	CD
cord-019001-ralxw4ad	78	30	]	]	-RRB-
cord-019001-ralxw4ad	78	31	.	.	.
cord-019001-ralxw4ad	79	1	These	these	DT
cord-019001-ralxw4ad	79	2	studies	study	NNS
cord-019001-ralxw4ad	79	3	have	have	VBP
cord-019001-ralxw4ad	79	4	shown	show	VBN
cord-019001-ralxw4ad	79	5	that	that	IN
cord-019001-ralxw4ad	79	6	this	this	DT
cord-019001-ralxw4ad	79	7	relationship	relationship	NN
cord-019001-ralxw4ad	79	8	to	to	TO
cord-019001-ralxw4ad	79	9	be	be	VB
cord-019001-ralxw4ad	79	10	U	u	NN
cord-019001-ralxw4ad	79	11	-	-	HYPH
cord-019001-ralxw4ad	79	12	shaped	shape	VBN
cord-019001-ralxw4ad	79	13	(	(	-LRB-
cord-019001-ralxw4ad	79	14	Figure	Figure	NNP
cord-019001-ralxw4ad	79	15	20.1	20.1	CD
cord-019001-ralxw4ad	79	16	)	)	-RRB-
cord-019001-ralxw4ad	79	17	with	with	IN
cord-019001-ralxw4ad	79	18	minimal	minimal	JJ
cord-019001-ralxw4ad	79	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	79	20	vascular	vascular	JJ
cord-019001-ralxw4ad	79	21	resistance	resistance	NN
cord-019001-ralxw4ad	79	22	noted	note	VBN
cord-019001-ralxw4ad	79	23	at	at	IN
cord-019001-ralxw4ad	79	24	functional	functional	JJ
cord-019001-ralxw4ad	79	25	residual	residual	JJ
cord-019001-ralxw4ad	79	26	capacity	capacity	NN
cord-019001-ralxw4ad	79	27	.	.	.
cord-019001-ralxw4ad	80	1	Using	use	VBG
cord-019001-ralxw4ad	80	2	an	an	DT
cord-019001-ralxw4ad	80	3	open	open	JJ
cord-019001-ralxw4ad	80	4	-	-	HYPH
cord-019001-ralxw4ad	80	5	chest	chest	NN
cord-019001-ralxw4ad	80	6	model	model	NN
cord-019001-ralxw4ad	80	7	,	,	,
cord-019001-ralxw4ad	80	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	80	9	vascular	vascular	JJ
cord-019001-ralxw4ad	80	10	resistance	resistance	NN
cord-019001-ralxw4ad	80	11	decreased	decrease	VBD
cord-019001-ralxw4ad	80	12	as	as	IN
cord-019001-ralxw4ad	80	13	lungs	lung	NNS
cord-019001-ralxw4ad	80	14	were	be	VBD
cord-019001-ralxw4ad	80	15	infl	infl	XX
cord-019001-ralxw4ad	80	16	ated	ate	VBN
cord-019001-ralxw4ad	80	17	from	from	IN
cord-019001-ralxw4ad	80	18	a	a	DT
cord-019001-ralxw4ad	80	19	collapsed	collapse	VBN
cord-019001-ralxw4ad	80	20	state	state	NN
cord-019001-ralxw4ad	80	21	and	and	CC
cord-019001-ralxw4ad	80	22	then	then	RB
cord-019001-ralxw4ad	80	23	progressively	progressively	RB
cord-019001-ralxw4ad	80	24	increased	increase	VBD
cord-019001-ralxw4ad	80	25	at	at	IN
cord-019001-ralxw4ad	80	26	higher	high	JJR
cord-019001-ralxw4ad	80	27	lung	lung	NN
cord-019001-ralxw4ad	80	28	volumes	volume	NNS
cord-019001-ralxw4ad	80	29	,	,	,
cord-019001-ralxw4ad	80	30	which	which	WDT
cord-019001-ralxw4ad	80	31	was	be	VBD
cord-019001-ralxw4ad	80	32	thought	think	VBN
cord-019001-ralxw4ad	80	33	to	to	TO
cord-019001-ralxw4ad	80	34	be	be	VB
cord-019001-ralxw4ad	80	35	related	relate	VBN
cord-019001-ralxw4ad	80	36	to	to	IN
cord-019001-ralxw4ad	80	37	infl	infl	NN
cord-019001-ralxw4ad	80	38	ation	ation	NN
cord-019001-ralxw4ad	80	39	pressure	pressure	NN
cord-019001-ralxw4ad	80	40	on	on	IN
cord-019001-ralxw4ad	80	41	the	the	DT
cord-019001-ralxw4ad	80	42	alveolar	alveolar	JJ
cord-019001-ralxw4ad	80	43	vessels	vessel	NNS
cord-019001-ralxw4ad	80	44	.	.	.
cord-019001-ralxw4ad	81	1	These	these	DT
cord-019001-ralxw4ad	81	2	observations	observation	NNS
cord-019001-ralxw4ad	81	3	support	support	VBP
cord-019001-ralxw4ad	81	4	the	the	DT
cord-019001-ralxw4ad	81	5	concept	concept	NN
cord-019001-ralxw4ad	81	6	that	that	IN
cord-019001-ralxw4ad	81	7	lung	lung	NN
cord-019001-ralxw4ad	81	8	infl	infl	NN
cord-019001-ralxw4ad	81	9	ation	ation	NN
cord-019001-ralxw4ad	81	10	may	may	MD
cord-019001-ralxw4ad	81	11	have	have	VB
cord-019001-ralxw4ad	81	12	a	a	DT
cord-019001-ralxw4ad	81	13	variable	variable	JJ
cord-019001-ralxw4ad	81	14	effect	effect	NN
cord-019001-ralxw4ad	81	15	on	on	IN
cord-019001-ralxw4ad	81	16	the	the	DT
cord-019001-ralxw4ad	81	17	distribution	distribution	NN
cord-019001-ralxw4ad	81	18	of	of	IN
cord-019001-ralxw4ad	81	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	81	20	blood	blood	NN
cord-019001-ralxw4ad	81	21	fl	fl	NNP
cord-019001-ralxw4ad	81	22	ow	ow	UH
cord-019001-ralxw4ad	81	23	.	.	.
cord-019001-ralxw4ad	82	1	When	when	WRB
cord-019001-ralxw4ad	82	2	pressure	pressure	NN
cord-019001-ralxw4ad	82	3	is	be	VBZ
cord-019001-ralxw4ad	82	4	expressed	express	VBN
cord-019001-ralxw4ad	82	5	in	in	IN
cord-019001-ralxw4ad	82	6	mm	mm	NN
cord-019001-ralxw4ad	82	7	of	of	IN
cord-019001-ralxw4ad	82	8	Hg	Hg	NNP
cord-019001-ralxw4ad	82	9	and	and	CC
cord-019001-ralxw4ad	82	10	fl	fl	NNP
cord-019001-ralxw4ad	83	1	ow	ow	UH
cord-019001-ralxw4ad	83	2	in	in	IN
cord-019001-ralxw4ad	83	3	L	L	NNP
cord-019001-ralxw4ad	83	4	/	/	SYM
cord-019001-ralxw4ad	83	5	min	min	NN
cord-019001-ralxw4ad	83	6	,	,	,
cord-019001-ralxw4ad	83	7	units	unit	NNS
cord-019001-ralxw4ad	83	8	of	of	IN
cord-019001-ralxw4ad	83	9	resistance	resistance	NN
cord-019001-ralxw4ad	83	10	are	be	VBP
cord-019001-ralxw4ad	83	11	derived	derive	VBN
cord-019001-ralxw4ad	83	12	as	as	IN
cord-019001-ralxw4ad	83	13	mm	mm	NN
cord-019001-ralxw4ad	83	14	of	of	IN
cord-019001-ralxw4ad	83	15	Hg	Hg	NNP
cord-019001-ralxw4ad	83	16	/	/	SYM
cord-019001-ralxw4ad	83	17	L	L	NNP
cord-019001-ralxw4ad	83	18	/	/	SYM
cord-019001-ralxw4ad	83	19	min	min	NNP
cord-019001-ralxw4ad	83	20	(	(	-LRB-
cord-019001-ralxw4ad	83	21	Wood	Wood	NNP
cord-019001-ralxw4ad	83	22	unit	unit	NN
cord-019001-ralxw4ad	83	23	,	,	,
cord-019001-ralxw4ad	83	24	U	U	NNP
cord-019001-ralxw4ad	83	25	)	)	-RRB-
cord-019001-ralxw4ad	83	26	.	.	.
cord-019001-ralxw4ad	84	1	However	however	RB
cord-019001-ralxw4ad	84	2	,	,	,
cord-019001-ralxw4ad	84	3	comparisons	comparison	NNS
cord-019001-ralxw4ad	84	4	among	among	IN
cord-019001-ralxw4ad	84	5	patients	patient	NNS
cord-019001-ralxw4ad	84	6	of	of	IN
cord-019001-ralxw4ad	84	7	differing	differ	VBG
cord-019001-ralxw4ad	84	8	weight	weight	NN
cord-019001-ralxw4ad	84	9	and	and	CC
cord-019001-ralxw4ad	84	10	age	age	NN
cord-019001-ralxw4ad	84	11	are	be	VBP
cord-019001-ralxw4ad	84	12	problematic	problematic	JJ
cord-019001-ralxw4ad	84	13	.	.	.
cord-019001-ralxw4ad	85	1	Therefore	therefore	RB
cord-019001-ralxw4ad	85	2	,	,	,
cord-019001-ralxw4ad	85	3	resistance	resistance	NN
cord-019001-ralxw4ad	85	4	is	be	VBZ
cord-019001-ralxw4ad	85	5	more	more	RBR
cord-019001-ralxw4ad	85	6	commonly	commonly	RB
cord-019001-ralxw4ad	85	7	expressed	express	VBN
cord-019001-ralxw4ad	85	8	in	in	IN
cord-019001-ralxw4ad	85	9	relation	relation	NN
cord-019001-ralxw4ad	85	10	to	to	IN
cord-019001-ralxw4ad	85	11	body	body	NN
cord-019001-ralxw4ad	85	12	surface	surface	NN
cord-019001-ralxw4ad	85	13	area	area	NN
cord-019001-ralxw4ad	85	14	,	,	,
cord-019001-ralxw4ad	85	15	as	as	IN
cord-019001-ralxw4ad	85	16	U·m	u·m	CD
cord-019001-ralxw4ad	85	17	2	2	CD
cord-019001-ralxw4ad	85	18	.	.	.
cord-019001-ralxw4ad	86	1	Multiplying	multiply	VBG
cord-019001-ralxw4ad	86	2	U	U	NNP
cord-019001-ralxw4ad	86	3	by	by	IN
cord-019001-ralxw4ad	86	4	80	80	CD
cord-019001-ralxw4ad	86	5	converts	convert	NNS
cord-019001-ralxw4ad	86	6	to	to	IN
cord-019001-ralxw4ad	86	7	dynes	dynes	NNP
cord-019001-ralxw4ad	86	8	/	/	SYM
cord-019001-ralxw4ad	86	9	sec	sec	NNP
cord-019001-ralxw4ad	86	10	/	/	SYM
cord-019001-ralxw4ad	86	11	cm	cm	NNP
cord-019001-ralxw4ad	86	12	−5	−5	NNP
cord-019001-ralxw4ad	86	13	,	,	,
cord-019001-ralxw4ad	86	14	a	a	DT
cord-019001-ralxw4ad	86	15	common	common	JJ
cord-019001-ralxw4ad	86	16	form	form	NN
cord-019001-ralxw4ad	86	17	utilized	utilize	VBN
cord-019001-ralxw4ad	86	18	to	to	TO
cord-019001-ralxw4ad	86	19	express	express	VB
cord-019001-ralxw4ad	86	20	resistance	resistance	NN
cord-019001-ralxw4ad	86	21	in	in	IN
cord-019001-ralxw4ad	86	22	other	other	JJ
cord-019001-ralxw4ad	86	23	settings	setting	NNS
cord-019001-ralxw4ad	86	24	.	.	.
cord-019001-ralxw4ad	87	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	87	2	vascular	vascular	JJ
cord-019001-ralxw4ad	87	3	resistance	resistance	NN
cord-019001-ralxw4ad	87	4	may	may	MD
cord-019001-ralxw4ad	87	5	be	be	VB
cord-019001-ralxw4ad	87	6	as	as	RB
cord-019001-ralxw4ad	87	7	high	high	JJ
cord-019001-ralxw4ad	87	8	as	as	IN
cord-019001-ralxw4ad	87	9	8	8	CD
cord-019001-ralxw4ad	87	10	-	-	SYM
cord-019001-ralxw4ad	87	11	10	10	CD
cord-019001-ralxw4ad	87	12	U·m	u·m	CD
cord-019001-ralxw4ad	87	13	2	2	CD
cord-019001-ralxw4ad	87	14	immediately	immediately	RB
cord-019001-ralxw4ad	87	15	after	after	IN
cord-019001-ralxw4ad	87	16	birth	birth	NN
cord-019001-ralxw4ad	88	1	and	and	CC
cord-019001-ralxw4ad	88	2	then	then	RB
cord-019001-ralxw4ad	88	3	,	,	,
cord-019001-ralxw4ad	88	4	under	under	IN
cord-019001-ralxw4ad	88	5	normal	normal	JJ
cord-019001-ralxw4ad	88	6	conditions	condition	NNS
cord-019001-ralxw4ad	88	7	,	,	,
cord-019001-ralxw4ad	88	8	falls	fall	VBZ
cord-019001-ralxw4ad	88	9	as	as	IN
cord-019001-ralxw4ad	88	10	previously	previously	RB
cord-019001-ralxw4ad	88	11	described	describe	VBN
cord-019001-ralxw4ad	88	12	to	to	IN
cord-019001-ralxw4ad	88	13	adult	adult	NN
cord-019001-ralxw4ad	88	14	levels	level	NNS
cord-019001-ralxw4ad	88	15	of	of	IN
cord-019001-ralxw4ad	88	16	1	1	CD
cord-019001-ralxw4ad	88	17	-	-	SYM
cord-019001-ralxw4ad	88	18	3	3	CD
cord-019001-ralxw4ad	88	19	U·m	u·m	CD
cord-019001-ralxw4ad	88	20	2	2	CD
cord-019001-ralxw4ad	88	21	by	by	IN
cord-019001-ralxw4ad	88	22	6	6	CD
cord-019001-ralxw4ad	88	23	to	to	TO
cord-019001-ralxw4ad	88	24	8	8	CD
cord-019001-ralxw4ad	88	25	weeks	week	NNS
cord-019001-ralxw4ad	88	26	of	of	IN
cord-019001-ralxw4ad	88	27	life	life	NN
cord-019001-ralxw4ad	88	28	[	[	-LRB-
cord-019001-ralxw4ad	88	29	27	27	CD
cord-019001-ralxw4ad	88	30	,	,	,
cord-019001-ralxw4ad	88	31	31	31	CD
cord-019001-ralxw4ad	88	32	]	]	-RRB-
cord-019001-ralxw4ad	88	33	.	.	.
cord-019001-ralxw4ad	89	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	89	2	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	89	3	disorders	disorder	NNS
cord-019001-ralxw4ad	89	4	are	be	VBP
cord-019001-ralxw4ad	89	5	a	a	DT
cord-019001-ralxw4ad	89	6	signifi	signifi	NN
cord-019001-ralxw4ad	89	7	ca	can	MD
cord-019001-ralxw4ad	89	8	nt	not	RB
cord-019001-ralxw4ad	89	9	source	source	NN
cord-019001-ralxw4ad	89	10	of	of	IN
cord-019001-ralxw4ad	89	11	morbidity	morbidity	NN
cord-019001-ralxw4ad	89	12	and	and	CC
cord-019001-ralxw4ad	89	13	mortality	mortality	NN
cord-019001-ralxw4ad	89	14	in	in	IN
cord-019001-ralxw4ad	89	15	the	the	DT
cord-019001-ralxw4ad	89	16	pediatric	pediatric	JJ
cord-019001-ralxw4ad	89	17	population	population	NN
cord-019001-ralxw4ad	89	18	.	.	.
cord-019001-ralxw4ad	90	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	90	2	hypertension	hypertension	NN
cord-019001-ralxw4ad	90	3	is	be	VBZ
cord-019001-ralxw4ad	90	4	defi	defi	NNP
cord-019001-ralxw4ad	90	5	ned	ned	NNP
cord-019001-ralxw4ad	90	6	as	as	IN
cord-019001-ralxw4ad	90	7	a	a	DT
cord-019001-ralxw4ad	90	8	mean	mean	JJ
cord-019001-ralxw4ad	90	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	90	10	artery	artery	NN
cord-019001-ralxw4ad	90	11	pressure	pressure	NN
cord-019001-ralxw4ad	90	12	of	of	IN
cord-019001-ralxw4ad	90	13	greater	great	JJR
cord-019001-ralxw4ad	90	14	than	than	IN
cord-019001-ralxw4ad	90	15	25	25	CD
cord-019001-ralxw4ad	90	16	mm	mm	NNS
cord-019001-ralxw4ad	90	17	of	of	IN
cord-019001-ralxw4ad	90	18	Hg	Hg	NNP
cord-019001-ralxw4ad	90	19	at	at	IN
cord-019001-ralxw4ad	90	20	rest	rest	NN
cord-019001-ralxw4ad	90	21	or	or	CC
cord-019001-ralxw4ad	90	22	greater	great	JJR
cord-019001-ralxw4ad	90	23	than	than	IN
cord-019001-ralxw4ad	90	24	30	30	CD
cord-019001-ralxw4ad	90	25	mm	mm	NNS
cord-019001-ralxw4ad	90	26	of	of	IN
cord-019001-ralxw4ad	90	27	Hg	Hg	NNP
cord-019001-ralxw4ad	90	28	during	during	IN
cord-019001-ralxw4ad	90	29	exercise	exercise	NN
cord-019001-ralxw4ad	90	30	.	.	.
cord-019001-ralxw4ad	91	1	In	in	IN
cord-019001-ralxw4ad	91	2	addition	addition	NN
cord-019001-ralxw4ad	91	3	,	,	,
cord-019001-ralxw4ad	91	4	a	a	DT
cord-019001-ralxw4ad	91	5	calculated	calculate	VBN
cord-019001-ralxw4ad	91	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	91	7	vascular	vascular	JJ
cord-019001-ralxw4ad	91	8	resistance	resistance	NN
cord-019001-ralxw4ad	91	9	of	of	IN
cord-019001-ralxw4ad	91	10	greater	great	JJR
cord-019001-ralxw4ad	91	11	than	than	IN
cord-019001-ralxw4ad	91	12	3	3	CD
cord-019001-ralxw4ad	91	13	U	u	NN
cord-019001-ralxw4ad	91	14	is	be	VBZ
cord-019001-ralxw4ad	91	15	generally	generally	RB
cord-019001-ralxw4ad	91	16	considered	consider	VBN
cord-019001-ralxw4ad	91	17	abnormal	abnormal	JJ
cord-019001-ralxw4ad	91	18	.	.	.
cord-019001-ralxw4ad	92	1	In	in	IN
cord-019001-ralxw4ad	92	2	neonates	neonate	NNS
cord-019001-ralxw4ad	92	3	,	,	,
cord-019001-ralxw4ad	92	4	the	the	DT
cord-019001-ralxw4ad	92	5	most	most	RBS
cord-019001-ralxw4ad	92	6	common	common	JJ
cord-019001-ralxw4ad	92	7	etiology	etiology	NN
cord-019001-ralxw4ad	92	8	results	result	NNS
cord-019001-ralxw4ad	92	9	from	from	IN
cord-019001-ralxw4ad	92	10	a	a	DT
cord-019001-ralxw4ad	92	11	failure	failure	NN
cord-019001-ralxw4ad	92	12	to	to	TO
cord-019001-ralxw4ad	92	13	undergo	undergo	VB
cord-019001-ralxw4ad	92	14	the	the	DT
cord-019001-ralxw4ad	92	15	normal	normal	JJ
cord-019001-ralxw4ad	92	16	fall	fall	NN
cord-019001-ralxw4ad	92	17	in	in	IN
cord-019001-ralxw4ad	92	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	92	19	vascular	vascular	JJ
cord-019001-ralxw4ad	92	20	resistance	resistance	NN
cord-019001-ralxw4ad	92	21	at	at	IN
cord-019001-ralxw4ad	92	22	birth	birth	NN
cord-019001-ralxw4ad	92	23	termed	term	VBD
cord-019001-ralxw4ad	92	24	persistent	persistent	JJ
cord-019001-ralxw4ad	92	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	92	26	hypertension	hypertension	NN
cord-019001-ralxw4ad	92	27	of	of	IN
cord-019001-ralxw4ad	92	28	the	the	DT
cord-019001-ralxw4ad	92	29	newborn	newborn	JJ
cord-019001-ralxw4ad	92	30	(	(	-LRB-
cord-019001-ralxw4ad	92	31	PPHN	PPHN	NNP
cord-019001-ralxw4ad	92	32	)	)	-RRB-
cord-019001-ralxw4ad	92	33	that	that	WDT
cord-019001-ralxw4ad	92	34	has	have	VBZ
cord-019001-ralxw4ad	92	35	an	an	DT
cord-019001-ralxw4ad	92	36	incidence	incidence	NN
cord-019001-ralxw4ad	92	37	of	of	IN
cord-019001-ralxw4ad	92	38	∼1	∼1	NNS
cord-019001-ralxw4ad	92	39	per	per	IN
cord-019001-ralxw4ad	92	40	1,000	1,000	CD
cord-019001-ralxw4ad	92	41	live	live	JJ
cord-019001-ralxw4ad	92	42	births	birth	NNS
cord-019001-ralxw4ad	92	43	.	.	.
cord-019001-ralxw4ad	93	1	However	however	RB
cord-019001-ralxw4ad	93	2	,	,	,
cord-019001-ralxw4ad	93	3	other	other	JJ
cord-019001-ralxw4ad	93	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	93	5	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	93	6	,	,	,
cord-019001-ralxw4ad	93	7	such	such	JJ
cord-019001-ralxw4ad	93	8	as	as	IN
cord-019001-ralxw4ad	93	9	congenital	congenital	JJ
cord-019001-ralxw4ad	93	10	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	93	11	hernia	hernia	NN
cord-019001-ralxw4ad	93	12	,	,	,
cord-019001-ralxw4ad	93	13	respiratory	respiratory	JJ
cord-019001-ralxw4ad	93	14	distress	distress	NN
cord-019001-ralxw4ad	93	15	syndrome	syndrome	NN
cord-019001-ralxw4ad	93	16	,	,	,
cord-019001-ralxw4ad	93	17	and	and	CC
cord-019001-ralxw4ad	93	18	bronchopulmonary	bronchopulmonary	JJ
cord-019001-ralxw4ad	93	19	dysplasia	dysplasia	NN
cord-019001-ralxw4ad	93	20	,	,	,
cord-019001-ralxw4ad	93	21	may	may	MD
cord-019001-ralxw4ad	93	22	also	also	RB
cord-019001-ralxw4ad	93	23	result	result	VB
cord-019001-ralxw4ad	93	24	in	in	IN
cord-019001-ralxw4ad	93	25	neonatal	neonatal	JJ
cord-019001-ralxw4ad	93	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	93	27	hypertension	hypertension	NN
cord-019001-ralxw4ad	93	28	.	.	.
cord-019001-ralxw4ad	94	1	Beyond	beyond	IN
cord-019001-ralxw4ad	94	2	the	the	DT
cord-019001-ralxw4ad	94	3	neonatal	neonatal	JJ
cord-019001-ralxw4ad	94	4	period	period	NN
cord-019001-ralxw4ad	94	5	,	,	,
cord-019001-ralxw4ad	94	6	the	the	DT
cord-019001-ralxw4ad	94	7	majority	majority	NN
cord-019001-ralxw4ad	94	8	of	of	IN
cord-019001-ralxw4ad	94	9	pediatric	pediatric	JJ
cord-019001-ralxw4ad	94	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	94	11	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	94	12	disorders	disorder	NNS
cord-019001-ralxw4ad	94	13	are	be	VBP
cord-019001-ralxw4ad	94	14	associated	associate	VBN
cord-019001-ralxw4ad	94	15	with	with	IN
cord-019001-ralxw4ad	94	16	congenital	congenital	JJ
cord-019001-ralxw4ad	94	17	heart	heart	NN
cord-019001-ralxw4ad	94	18	defects	defect	NNS
cord-019001-ralxw4ad	94	19	.	.	.
cord-019001-ralxw4ad	95	1	Other	other	JJ
cord-019001-ralxw4ad	95	2	,	,	,
cord-019001-ralxw4ad	95	3	less	less	RBR
cord-019001-ralxw4ad	95	4	common	common	JJ
cord-019001-ralxw4ad	95	5	causes	cause	NNS
cord-019001-ralxw4ad	95	6	of	of	IN
cord-019001-ralxw4ad	95	7	pediatric	pediatric	JJ
cord-019001-ralxw4ad	95	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	95	9	vascular	vascular	JJ
cord-019001-ralxw4ad	95	10	disease	disease	NN
cord-019001-ralxw4ad	95	11	include	include	VBP
cord-019001-ralxw4ad	95	12	primary	primary	JJ
cord-019001-ralxw4ad	95	13	(	(	-LRB-
cord-019001-ralxw4ad	95	14	idiopathic	idiopathic	JJ
cord-019001-ralxw4ad	95	15	)	)	-RRB-
cord-019001-ralxw4ad	95	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	95	17	hypertension	hypertension	NN
cord-019001-ralxw4ad	95	18	,	,	,
cord-019001-ralxw4ad	95	19	hypoxiainduced	hypoxiainduced	JJ
cord-019001-ralxw4ad	95	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	95	21	vascular	vascular	JJ
cord-019001-ralxw4ad	95	22	disease	disease	NN
cord-019001-ralxw4ad	95	23	,	,	,
cord-019001-ralxw4ad	95	24	rheumatologic	rheumatologic	JJ
cord-019001-ralxw4ad	95	25	disorders	disorder	NNS
cord-019001-ralxw4ad	95	26	,	,	,
cord-019001-ralxw4ad	95	27	sickle	sickle	NN
cord-019001-ralxw4ad	95	28	cell	cell	NN
cord-019001-ralxw4ad	95	29	disease	disease	NN
cord-019001-ralxw4ad	95	30	,	,	,
cord-019001-ralxw4ad	95	31	portal	portal	JJ
cord-019001-ralxw4ad	95	32	hypertension	hypertension	NN
cord-019001-ralxw4ad	95	33	,	,	,
cord-019001-ralxw4ad	95	34	chronic	chronic	JJ
cord-019001-ralxw4ad	95	35	thromboembolic	thromboembolic	JJ
cord-019001-ralxw4ad	95	36	disease	disease	NN
cord-019001-ralxw4ad	95	37	,	,	,
cord-019001-ralxw4ad	95	38	human	human	JJ
cord-019001-ralxw4ad	95	39	immunodefi	immunodefi	NNP
cord-019001-ralxw4ad	95	40	ciency	ciency	NNP
cord-019001-ralxw4ad	95	41	virus	virus	NN
cord-019001-ralxw4ad	95	42	disease	disease	NN
cord-019001-ralxw4ad	95	43	,	,	,
cord-019001-ralxw4ad	95	44	and	and	CC
cord-019001-ralxw4ad	95	45	drug	drug	NN
cord-019001-ralxw4ad	95	46	-	-	HYPH
cord-019001-ralxw4ad	95	47	toxin	toxin	NN
cord-019001-ralxw4ad	95	48	induced	induce	VBN
cord-019001-ralxw4ad	95	49	disease	disease	NN
cord-019001-ralxw4ad	95	50	.	.	.
cord-019001-ralxw4ad	96	1	A	a	DT
cord-019001-ralxw4ad	96	2	number	number	NN
cord-019001-ralxw4ad	96	3	of	of	IN
cord-019001-ralxw4ad	96	4	clinical	clinical	JJ
cord-019001-ralxw4ad	96	5	classifi	classifi	NNP
cord-019001-ralxw4ad	96	6	cation	cation	NN
cord-019001-ralxw4ad	96	7	systems	system	NNS
cord-019001-ralxw4ad	96	8	for	for	IN
cord-019001-ralxw4ad	96	9	 	 	_SP
cord-019001-ralxw4ad	96	10	Vascular	vascular	JJ
cord-019001-ralxw4ad	96	11	endothelial	endothelial	JJ
cord-019001-ralxw4ad	96	12	cells	cell	NNS
cord-019001-ralxw4ad	96	13	are	be	VBP
cord-019001-ralxw4ad	96	14	capable	capable	JJ
cord-019001-ralxw4ad	96	15	of	of	IN
cord-019001-ralxw4ad	96	16	producing	produce	VBG
cord-019001-ralxw4ad	96	17	a	a	DT
cord-019001-ralxw4ad	96	18	variety	variety	NN
cord-019001-ralxw4ad	96	19	of	of	IN
cord-019001-ralxw4ad	96	20	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	96	21	substances	substance	NNS
cord-019001-ralxw4ad	96	22	that	that	WDT
cord-019001-ralxw4ad	96	23	participate	participate	VBP
cord-019001-ralxw4ad	96	24	in	in	IN
cord-019001-ralxw4ad	96	25	the	the	DT
cord-019001-ralxw4ad	96	26	regulation	regulation	NN
cord-019001-ralxw4ad	96	27	of	of	IN
cord-019001-ralxw4ad	96	28	normal	normal	JJ
cord-019001-ralxw4ad	96	29	vascular	vascular	JJ
cord-019001-ralxw4ad	96	30	tone	tone	NN
cord-019001-ralxw4ad	96	31	.	.	.
cord-019001-ralxw4ad	97	1	A	a	DT
cord-019001-ralxw4ad	97	2	schematic	schematic	NN
cord-019001-ralxw4ad	97	3	of	of	IN
cord-019001-ralxw4ad	97	4	some	some	DT
cord-019001-ralxw4ad	97	5	of	of	IN
cord-019001-ralxw4ad	97	6	these	these	DT
cord-019001-ralxw4ad	97	7	endothelial	endothelial	JJ
cord-019001-ralxw4ad	97	8	factors	factor	NNS
cord-019001-ralxw4ad	97	9	is	be	VBZ
cord-019001-ralxw4ad	97	10	shown	show	VBN
cord-019001-ralxw4ad	97	11	in	in	IN
cord-019001-ralxw4ad	97	12	Figure	figure	NN
cord-019001-ralxw4ad	97	13	20	20	CD
cord-019001-ralxw4ad	97	14	.2	.2	CD
cord-019001-ralxw4ad	97	15	.	.	.
cord-019001-ralxw4ad	98	1	These	these	DT
cord-019001-ralxw4ad	98	2	substances	substance	NNS
cord-019001-ralxw4ad	98	3	,	,	,
cord-019001-ralxw4ad	98	4	such	such	JJ
cord-019001-ralxw4ad	98	5	as	as	IN
cord-019001-ralxw4ad	98	6	NO	no	RB
cord-019001-ralxw4ad	98	7	,	,	,
cord-019001-ralxw4ad	98	8	ET-1	ET-1	NNP
cord-019001-ralxw4ad	98	9	,	,	,
cord-019001-ralxw4ad	98	10	and	and	CC
cord-019001-ralxw4ad	98	11	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	98	12	are	be	VBP
cord-019001-ralxw4ad	98	13	capable	capable	JJ
cord-019001-ralxw4ad	98	14	of	of	IN
cord-019001-ralxw4ad	98	15	producing	produce	VBG
cord-019001-ralxw4ad	98	16	vascular	vascular	JJ
cord-019001-ralxw4ad	98	17	relaxation	relaxation	NN
cord-019001-ralxw4ad	98	18	and/or	and/or	CC
cord-019001-ralxw4ad	98	19	constriction	constriction	NN
cord-019001-ralxw4ad	98	20	,	,	,
cord-019001-ralxw4ad	98	21	modulating	modulate	VBG
cord-019001-ralxw4ad	98	22	the	the	DT
cord-019001-ralxw4ad	98	23	propensity	propensity	NN
cord-019001-ralxw4ad	98	24	of	of	IN
cord-019001-ralxw4ad	98	25	the	the	DT
cord-019001-ralxw4ad	98	26	blood	blood	NN
cord-019001-ralxw4ad	98	27	to	to	TO
cord-019001-ralxw4ad	98	28	clot	clot	NN
cord-019001-ralxw4ad	98	29	,	,	,
cord-019001-ralxw4ad	98	30	and	and	CC
cord-019001-ralxw4ad	98	31	inducing	induce	VBG
cord-019001-ralxw4ad	98	32	and/or	and/or	CC
cord-019001-ralxw4ad	98	33	inhibiting	inhibit	VBG
cord-019001-ralxw4ad	98	34	smooth	smooth	JJ
cord-019001-ralxw4ad	98	35	muscle	muscle	NN
cord-019001-ralxw4ad	98	36	cell	cell	NN
cord-019001-ralxw4ad	98	37	migration	migration	NN
cord-019001-ralxw4ad	98	38	and	and	CC
cord-019001-ralxw4ad	98	39	replication	replication	NN
cord-019001-ralxw4ad	98	40	[	[	-LRB-
cord-019001-ralxw4ad	98	41	6	6	CD
cord-019001-ralxw4ad	98	42	]	]	-RRB-
cord-019001-ralxw4ad	98	43	[	[	-LRB-
cord-019001-ralxw4ad	98	44	7	7	CD
cord-019001-ralxw4ad	98	45	]	]	-RRB-
cord-019001-ralxw4ad	98	46	[	[	-LRB-
cord-019001-ralxw4ad	98	47	8	8	CD
cord-019001-ralxw4ad	98	48	]	]	-RRB-
cord-019001-ralxw4ad	98	49	[	[	-LRB-
cord-019001-ralxw4ad	98	50	9	9	CD
cord-019001-ralxw4ad	98	51	]	]	-RRB-
cord-019001-ralxw4ad	98	52	[	[	-LRB-
cord-019001-ralxw4ad	98	53	10	10	CD
cord-019001-ralxw4ad	98	54	]	]	-RRB-
cord-019001-ralxw4ad	98	55	[	[	-LRB-
cord-019001-ralxw4ad	98	56	11	11	CD
cord-019001-ralxw4ad	98	57	]	]	-RRB-
cord-019001-ralxw4ad	98	58	[	[	-LRB-
cord-019001-ralxw4ad	98	59	12	12	CD
cord-019001-ralxw4ad	98	60	]	]	-RRB-
cord-019001-ralxw4ad	98	61	[	[	-LRB-
cord-019001-ralxw4ad	98	62	13	13	CD
cord-019001-ralxw4ad	98	63	]	]	-RRB-
cord-019001-ralxw4ad	98	64	[	[	-LRB-
cord-019001-ralxw4ad	98	65	14	14	CD
cord-019001-ralxw4ad	98	66	]	]	-RRB-
cord-019001-ralxw4ad	98	67	[	[	-LRB-
cord-019001-ralxw4ad	98	68	15	15	CD
cord-019001-ralxw4ad	98	69	]	]	-RRB-
cord-019001-ralxw4ad	98	70	[	[	-LRB-
cord-019001-ralxw4ad	98	71	16	16	CD
cord-019001-ralxw4ad	98	72	]	]	-RRB-
cord-019001-ralxw4ad	98	73	[	[	-LRB-
cord-019001-ralxw4ad	98	74	17	17	CD
cord-019001-ralxw4ad	98	75	]	]	-RRB-
cord-019001-ralxw4ad	98	76	[	[	-LRB-
cord-019001-ralxw4ad	98	77	18	18	CD
cord-019001-ralxw4ad	98	78	]	]	-RRB-
cord-019001-ralxw4ad	98	79	[	[	-LRB-
cord-019001-ralxw4ad	98	80	19	19	CD
cord-019001-ralxw4ad	98	81	]	]	-RRB-
cord-019001-ralxw4ad	98	82	[	[	-LRB-
cord-019001-ralxw4ad	98	83	20	20	CD
cord-019001-ralxw4ad	98	84	]	]	-RRB-
cord-019001-ralxw4ad	98	85	.	.	.
cord-019001-ralxw4ad	99	1	Nitric	nitric	NN
cord-019001-ralxw4ad	99	2	oxide	oxide	NN
cord-019001-ralxw4ad	99	3	is	be	VBZ
cord-019001-ralxw4ad	99	4	a	a	DT
cord-019001-ralxw4ad	99	5	labile	labile	JJ
cord-019001-ralxw4ad	99	6	humoral	humoral	JJ
cord-019001-ralxw4ad	99	7	factor	factor	NN
cord-019001-ralxw4ad	99	8	produced	produce	VBN
cord-019001-ralxw4ad	99	9	by	by	IN
cord-019001-ralxw4ad	99	10	nitric	nitric	NN
cord-019001-ralxw4ad	99	11	oxide	oxide	NN
cord-019001-ralxw4ad	99	12	synthase	synthase	NN
cord-019001-ralxw4ad	99	13	(	(	-LRB-
cord-019001-ralxw4ad	99	14	NOS	NOS	NNP
cord-019001-ralxw4ad	99	15	)	)	-RRB-
cord-019001-ralxw4ad	99	16	from	from	IN
cord-019001-ralxw4ad	99	17	L	l	NN
cord-019001-ralxw4ad	99	18	-	-	HYPH
cord-019001-ralxw4ad	99	19	arginine	arginine	NN
cord-019001-ralxw4ad	99	20	in	in	IN
cord-019001-ralxw4ad	99	21	the	the	DT
cord-019001-ralxw4ad	99	22	vascular	vascular	JJ
cord-019001-ralxw4ad	99	23	endothelial	endothelial	JJ
cord-019001-ralxw4ad	99	24	cell	cell	NN
cord-019001-ralxw4ad	99	25	[	[	-LRB-
cord-019001-ralxw4ad	99	26	86	86	CD
cord-019001-ralxw4ad	99	27	]	]	-RRB-
cord-019001-ralxw4ad	100	1	[	[	-LRB-
cord-019001-ralxw4ad	100	2	87	87	CD
cord-019001-ralxw4ad	100	3	]	]	-RRB-
cord-019001-ralxw4ad	100	4	[	[	-LRB-
cord-019001-ralxw4ad	100	5	88	88	CD
cord-019001-ralxw4ad	100	6	]	]	-RRB-
cord-019001-ralxw4ad	100	7	.	.	.
cord-019001-ralxw4ad	101	1	Nitric	nitric	NN
cord-019001-ralxw4ad	101	2	oxide	oxide	NN
cord-019001-ralxw4ad	101	3	diffuses	diffuse	VBZ
cord-019001-ralxw4ad	101	4	into	into	IN
cord-019001-ralxw4ad	101	5	the	the	DT
cord-019001-ralxw4ad	101	6	smooth	smooth	JJ
cord-019001-ralxw4ad	101	7	muscle	muscle	NN
cord-019001-ralxw4ad	101	8	cell	cell	NN
cord-019001-ralxw4ad	101	9	and	and	CC
cord-019001-ralxw4ad	101	10	produces	produce	VBZ
cord-019001-ralxw4ad	101	11	vascular	vascular	JJ
cord-019001-ralxw4ad	101	12	relaxation	relaxation	NN
cord-019001-ralxw4ad	101	13	by	by	IN
cord-019001-ralxw4ad	101	14	increasing	increase	VBG
cord-019001-ralxw4ad	101	15	concentrations	concentration	NNS
cord-019001-ralxw4ad	101	16	of	of	IN
cord-019001-ralxw4ad	101	17	guanosine	guanosine	NN
cord-019001-ralxw4ad	101	18	3′5′-monophosphate	3′5′-monophosphate	NN
cord-019001-ralxw4ad	101	19	(	(	-LRB-
cord-019001-ralxw4ad	101	20	cGMP	cGMP	NNP
cord-019001-ralxw4ad	101	21	)	)	-RRB-
cord-019001-ralxw4ad	102	1	via	via	IN
cord-019001-ralxw4ad	102	2	the	the	DT
cord-019001-ralxw4ad	102	3	activation	activation	NN
cord-019001-ralxw4ad	102	4	of	of	IN
cord-019001-ralxw4ad	102	5	soluble	soluble	JJ
cord-019001-ralxw4ad	102	6	guanylate	guanylate	NN
cord-019001-ralxw4ad	102	7	cyclase	cyclase	NN
cord-019001-ralxw4ad	102	8	[	[	-LRB-
cord-019001-ralxw4ad	102	9	89	89	CD
cord-019001-ralxw4ad	102	10	,	,	,
cord-019001-ralxw4ad	102	11	90	90	CD
cord-019001-ralxw4ad	102	12	]	]	-RRB-
cord-019001-ralxw4ad	102	13	.	.	.
cord-019001-ralxw4ad	103	1	Nitric	nitric	NN
cord-019001-ralxw4ad	103	2	oxide	oxide	NN
cord-019001-ralxw4ad	103	3	is	be	VBZ
cord-019001-ralxw4ad	103	4	released	release	VBN
cord-019001-ralxw4ad	103	5	in	in	IN
cord-019001-ralxw4ad	103	6	response	response	NN
cord-019001-ralxw4ad	103	7	to	to	IN
cord-019001-ralxw4ad	103	8	a	a	DT
cord-019001-ralxw4ad	103	9	variety	variety	NN
cord-019001-ralxw4ad	103	10	of	of	IN
cord-019001-ralxw4ad	103	11	factors	factor	NNS
cord-019001-ralxw4ad	103	12	,	,	,
cord-019001-ralxw4ad	103	13	including	include	VBG
cord-019001-ralxw4ad	103	14	shear	shear	NN
cord-019001-ralxw4ad	103	15	stress	stress	NN
cord-019001-ralxw4ad	103	16	(	(	-LRB-
cord-019001-ralxw4ad	103	17	fl	fl	NNP
cord-019001-ralxw4ad	103	18	ow	ow	NNP
cord-019001-ralxw4ad	103	19	)	)	-RRB-
cord-019001-ralxw4ad	103	20	and	and	CC
cord-019001-ralxw4ad	103	21	the	the	DT
cord-019001-ralxw4ad	103	22	binding	binding	NN
cord-019001-ralxw4ad	103	23	of	of	IN
cord-019001-ralxw4ad	103	24	certain	certain	JJ
cord-019001-ralxw4ad	103	25	endothelium	endothelium	NN
cord-019001-ralxw4ad	103	26	-	-	HYPH
cord-019001-ralxw4ad	103	27	dependent	dependent	JJ
cord-019001-ralxw4ad	103	28	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	103	29	(	(	-LRB-
cord-019001-ralxw4ad	103	30	such	such	JJ
cord-019001-ralxw4ad	103	31	as	as	IN
cord-019001-ralxw4ad	103	32	acetylcholine	acetylcholine	NN
cord-019001-ralxw4ad	103	33	,	,	,
cord-019001-ralxw4ad	103	34	adenosine	adenosine	NN
cord-019001-ralxw4ad	103	35	triphosphate	triphosphate	NN
cord-019001-ralxw4ad	103	36	[	[	-LRB-
cord-019001-ralxw4ad	103	37	ATP	ATP	NNP
cord-019001-ralxw4ad	103	38	]	]	-RRB-
cord-019001-ralxw4ad	103	39	,	,	,
cord-019001-ralxw4ad	103	40	and	and	CC
cord-019001-ralxw4ad	103	41	bradykinin	bradykinin	NN
cord-019001-ralxw4ad	103	42	)	)	-RRB-
cord-019001-ralxw4ad	103	43	to	to	IN
cord-019001-ralxw4ad	103	44	receptors	receptor	NNS
cord-019001-ralxw4ad	103	45	on	on	IN
cord-019001-ralxw4ad	103	46	the	the	DT
cord-019001-ralxw4ad	103	47	endothelial	endothelial	JJ
cord-019001-ralxw4ad	103	48	cell	cell	NN
cord-019001-ralxw4ad	103	49	[	[	-LRB-
cord-019001-ralxw4ad	103	50	4	4	CD
cord-019001-ralxw4ad	103	51	,	,	,
cord-019001-ralxw4ad	103	52	91	91	CD
cord-019001-ralxw4ad	103	53	]	]	-RRB-
cord-019001-ralxw4ad	103	54	.	.	.
cord-019001-ralxw4ad	104	1	Basal	basal	NN
cord-019001-ralxw4ad	105	1	NO	no	DT
cord-019001-ralxw4ad	105	2	release	release	NN
cord-019001-ralxw4ad	105	3	is	be	VBZ
cord-019001-ralxw4ad	105	4	an	an	DT
cord-019001-ralxw4ad	105	5	important	important	JJ
cord-019001-ralxw4ad	105	6	mediator	mediator	NN
cord-019001-ralxw4ad	105	7	of	of	IN
cord-019001-ralxw4ad	105	8	both	both	DT
cord-019001-ralxw4ad	105	9	resting	rest	VBG
cord-019001-ralxw4ad	105	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	105	11	and	and	CC
cord-019001-ralxw4ad	105	12	systemic	systemic	JJ
cord-019001-ralxw4ad	105	13	vascular	vascular	JJ
cord-019001-ralxw4ad	105	14	tone	tone	NN
cord-019001-ralxw4ad	105	15	in	in	IN
cord-019001-ralxw4ad	105	16	the	the	DT
cord-019001-ralxw4ad	105	17	fetus	fetus	NN
cord-019001-ralxw4ad	105	18	,	,	,
cord-019001-ralxw4ad	105	19	newborn	newborn	JJ
cord-019001-ralxw4ad	105	20	,	,	,
cord-019001-ralxw4ad	105	21	and	and	CC
cord-019001-ralxw4ad	105	22	adult	adult	NN
cord-019001-ralxw4ad	105	23	,	,	,
cord-019001-ralxw4ad	105	24	as	as	RB
cord-019001-ralxw4ad	105	25	well	well	RB
cord-019001-ralxw4ad	105	26	as	as	IN
cord-019001-ralxw4ad	105	27	a	a	DT
cord-019001-ralxw4ad	105	28	mediator	mediator	NN
cord-019001-ralxw4ad	105	29	of	of	IN
cord-019001-ralxw4ad	105	30	the	the	DT
cord-019001-ralxw4ad	105	31	normal	normal	JJ
cord-019001-ralxw4ad	105	32	fall	fall	NN
cord-019001-ralxw4ad	105	33	in	in	IN
cord-019001-ralxw4ad	105	34	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	105	35	vascular	vascular	JJ
cord-019001-ralxw4ad	105	36	resistance	resistance	NN
cord-019001-ralxw4ad	105	37	that	that	WDT
cord-019001-ralxw4ad	105	38	occurs	occur	VBZ
cord-019001-ralxw4ad	105	39	immediately	immediately	RB
cord-019001-ralxw4ad	105	40	after	after	IN
cord-019001-ralxw4ad	105	41	birth	birth	NN
cord-019001-ralxw4ad	105	42	32	32	CD
cord-019001-ralxw4ad	105	43	,	,	,
cord-019001-ralxw4ad	105	44	87	87	CD
cord-019001-ralxw4ad	105	45	,	,	,
cord-019001-ralxw4ad	105	46	92	92	CD
cord-019001-ralxw4ad	105	47	]	]	-RRB-
cord-019001-ralxw4ad	105	48	.	.	.
cord-019001-ralxw4ad	106	1	In	in	IN
cord-019001-ralxw4ad	106	2	addition	addition	NN
cord-019001-ralxw4ad	106	3	,	,	,
cord-019001-ralxw4ad	106	4	aberrant	aberrant	JJ
cord-019001-ralxw4ad	106	5	NO	no	RB
cord-019001-ralxw4ad	106	6	-	-	HYPH
cord-019001-ralxw4ad	106	7	cGMP	cgmp	JJ
cord-019001-ralxw4ad	106	8	signaling	signaling	NN
cord-019001-ralxw4ad	106	9	is	be	VBZ
cord-019001-ralxw4ad	106	10	integral	integral	JJ
cord-019001-ralxw4ad	106	11	to	to	IN
cord-019001-ralxw4ad	106	12	the	the	DT
cord-019001-ralxw4ad	106	13	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	106	14	of	of	IN
cord-019001-ralxw4ad	106	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	106	16	hypertension	hypertension	NN
cord-019001-ralxw4ad	106	17	,	,	,
cord-019001-ralxw4ad	106	18	as	as	RB
cord-019001-ralxw4ad	106	19	well	well	RB
cord-019001-ralxw4ad	106	20	as	as	IN
cord-019001-ralxw4ad	106	21	a	a	DT
cord-019001-ralxw4ad	106	22	number	number	NN
cord-019001-ralxw4ad	106	23	of	of	IN
cord-019001-ralxw4ad	106	24	other	other	JJ
cord-019001-ralxw4ad	106	25	biologic	biologic	JJ
cord-019001-ralxw4ad	106	26	vascular	vascular	JJ
cord-019001-ralxw4ad	106	27	disorders	disorder	NNS
cord-019001-ralxw4ad	106	28	[	[	-LRB-
cord-019001-ralxw4ad	106	29	10	10	CD
cord-019001-ralxw4ad	106	30	,	,	,
cord-019001-ralxw4ad	106	31	11	11	CD
cord-019001-ralxw4ad	106	32	,	,	,
cord-019001-ralxw4ad	106	33	23	23	CD
cord-019001-ralxw4ad	106	34	,	,	,
cord-019001-ralxw4ad	106	35	25	25	CD
cord-019001-ralxw4ad	106	36	,	,	,
cord-019001-ralxw4ad	106	37	44	44	CD
cord-019001-ralxw4ad	106	38	,	,	,
cord-019001-ralxw4ad	106	39	45	45	CD
cord-019001-ralxw4ad	106	40	,	,	,
cord-019001-ralxw4ad	106	41	48	48	CD
cord-019001-ralxw4ad	106	42	,	,	,
cord-019001-ralxw4ad	106	43	52	52	CD
cord-019001-ralxw4ad	106	44	]	]	-RRB-
cord-019001-ralxw4ad	106	45	.	.	.
cord-019001-ralxw4ad	107	1	Endothelin-1	Endothelin-1	NNP
cord-019001-ralxw4ad	107	2	is	be	VBZ
cord-019001-ralxw4ad	107	3	a	a	DT
cord-019001-ralxw4ad	107	4	21	21	CD
cord-019001-ralxw4ad	107	5	amino	amino	NN
cord-019001-ralxw4ad	107	6	acid	acid	NN
cord-019001-ralxw4ad	107	7	polypeptide	polypeptide	NN
cord-019001-ralxw4ad	107	8	also	also	RB
cord-019001-ralxw4ad	107	9	produced	produce	VBN
cord-019001-ralxw4ad	107	10	by	by	IN
cord-019001-ralxw4ad	107	11	vascular	vascular	JJ
cord-019001-ralxw4ad	107	12	endothelial	endothelial	JJ
cord-019001-ralxw4ad	107	13	cells	cell	NNS
cord-019001-ralxw4ad	107	14	[	[	-LRB-
cord-019001-ralxw4ad	107	15	2	2	CD
cord-019001-ralxw4ad	107	16	]	]	-RRB-
cord-019001-ralxw4ad	107	17	.	.	.
cord-019001-ralxw4ad	108	1	The	the	DT
cord-019001-ralxw4ad	108	2	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	108	3	properties	property	NNS
cord-019001-ralxw4ad	108	4	of	of	IN
cord-019001-ralxw4ad	108	5	ET-1	ET-1	NNP
cord-019001-ralxw4ad	108	6	are	be	VBP
cord-019001-ralxw4ad	108	7	complex	complex	JJ
cord-019001-ralxw4ad	108	8	,	,	,
cord-019001-ralxw4ad	108	9	and	and	CC
cord-019001-ralxw4ad	108	10	studies	study	NNS
cord-019001-ralxw4ad	108	11	have	have	VBP
cord-019001-ralxw4ad	108	12	shown	show	VBN
cord-019001-ralxw4ad	108	13	varying	vary	VBG
cord-019001-ralxw4ad	108	14	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	108	15	effects	effect	NNS
cord-019001-ralxw4ad	108	16	on	on	IN
cord-019001-ralxw4ad	108	17	different	different	JJ
cord-019001-ralxw4ad	108	18	vascular	vascular	JJ
cord-019001-ralxw4ad	108	19	beds	bed	NNS
cord-019001-ralxw4ad	108	20	[	[	-LRB-
cord-019001-ralxw4ad	108	21	16	16	CD
cord-019001-ralxw4ad	108	22	]	]	-RRB-
cord-019001-ralxw4ad	108	23	[	[	-LRB-
cord-019001-ralxw4ad	108	24	17	17	CD
cord-019001-ralxw4ad	108	25	]	]	-RRB-
cord-019001-ralxw4ad	108	26	[	[	-LRB-
cord-019001-ralxw4ad	108	27	18	18	CD
cord-019001-ralxw4ad	108	28	]	]	-RRB-
cord-019001-ralxw4ad	108	29	[	[	-LRB-
cord-019001-ralxw4ad	108	30	19	19	CD
cord-019001-ralxw4ad	108	31	]	]	-RRB-
cord-019001-ralxw4ad	108	32	[	[	-LRB-
cord-019001-ralxw4ad	108	33	20	20	CD
cord-019001-ralxw4ad	108	34	]	]	-RRB-
cord-019001-ralxw4ad	108	35	.	.	.
cord-019001-ralxw4ad	109	1	However	however	RB
cord-019001-ralxw4ad	109	2	,	,	,
cord-019001-ralxw4ad	109	3	its	-PRON-	PRP$
cord-019001-ralxw4ad	109	4	most	most	RBS
cord-019001-ralxw4ad	109	5	striking	striking	JJ
cord-019001-ralxw4ad	109	6	property	property	NN
cord-019001-ralxw4ad	109	7	is	be	VBZ
cord-019001-ralxw4ad	109	8	its	-PRON-	PRP$
cord-019001-ralxw4ad	109	9	sustained	sustained	JJ
cord-019001-ralxw4ad	109	10	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	109	11	action	action	NN
cord-019001-ralxw4ad	109	12	.	.	.
cord-019001-ralxw4ad	110	1	In	in	IN
cord-019001-ralxw4ad	110	2	fact	fact	NN
cord-019001-ralxw4ad	110	3	,	,	,
cord-019001-ralxw4ad	110	4	ET-1	ET-1	NNP
cord-019001-ralxw4ad	110	5	is	be	VBZ
cord-019001-ralxw4ad	110	6	the	the	DT
cord-019001-ralxw4ad	110	7	most	most	RBS
cord-019001-ralxw4ad	110	8	potent	potent	JJ
cord-019001-ralxw4ad	110	9	vasoconstricting	vasoconstricte	VBG
cord-019001-ralxw4ad	110	10	agent	agent	NN
cord-019001-ralxw4ad	110	11	discovered	discover	VBD
cord-019001-ralxw4ad	110	12	,	,	,
cord-019001-ralxw4ad	110	13	with	with	IN
cord-019001-ralxw4ad	110	14	a	a	DT
cord-019001-ralxw4ad	110	15	potency	potency	NN
cord-019001-ralxw4ad	110	16	10	10	CD
cord-019001-ralxw4ad	110	17	times	time	NNS
cord-019001-ralxw4ad	110	18	that	that	DT
cord-019001-ralxw4ad	110	19	of	of	IN
cord-019001-ralxw4ad	110	20	angiotensin	angiotensin	NN
cord-019001-ralxw4ad	110	21	II	II	NNP
cord-019001-ralxw4ad	110	22	.	.	.
cord-019001-ralxw4ad	111	1	The	the	DT
cord-019001-ralxw4ad	111	2	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	111	3	effects	effect	NNS
cord-019001-ralxw4ad	111	4	of	of	IN
cord-019001-ralxw4ad	111	5	ET-1	ET-1	NNP
cord-019001-ralxw4ad	111	6	are	be	VBP
cord-019001-ralxw4ad	111	7	mediated	mediate	VBN
cord-019001-ralxw4ad	111	8	by	by	IN
cord-019001-ralxw4ad	111	9	at	at	RB
cord-019001-ralxw4ad	111	10	least	least	JJS
cord-019001-ralxw4ad	111	11	two	two	CD
cord-019001-ralxw4ad	111	12	distinct	distinct	JJ
cord-019001-ralxw4ad	111	13	receptor	receptor	NN
cord-019001-ralxw4ad	111	14	populations	population	NNS
cord-019001-ralxw4ad	111	15	,	,	,
cord-019001-ralxw4ad	111	16	ET	ET	NNP
cord-019001-ralxw4ad	111	17	A	A	NNP
cord-019001-ralxw4ad	111	18	and	and	CC
cord-019001-ralxw4ad	111	19	ET	ET	NNP
cord-019001-ralxw4ad	111	20	B	B	NNP
cord-019001-ralxw4ad	111	21	[	[	-LRB-
cord-019001-ralxw4ad	111	22	93	93	CD
cord-019001-ralxw4ad	111	23	,	,	,
cord-019001-ralxw4ad	111	24	94	94	CD
cord-019001-ralxw4ad	111	25	]	]	-RRB-
cord-019001-ralxw4ad	111	26	.	.	.
cord-019001-ralxw4ad	112	1	The	the	DT
cord-019001-ralxw4ad	112	2	ET	ET	NNP
cord-019001-ralxw4ad	112	3	A	a	DT
cord-019001-ralxw4ad	112	4	receptors	receptor	NNS
cord-019001-ralxw4ad	112	5	are	be	VBP
cord-019001-ralxw4ad	112	6	located	locate	VBN
cord-019001-ralxw4ad	112	7	on	on	IN
cord-019001-ralxw4ad	112	8	vascular	vascular	JJ
cord-019001-ralxw4ad	112	9	smooth	smooth	JJ
cord-019001-ralxw4ad	112	10	muscle	muscle	NN
cord-019001-ralxw4ad	112	11	cells	cell	NNS
cord-019001-ralxw4ad	112	12	and	and	CC
cord-019001-ralxw4ad	112	13	mediate	mediate	VB
cord-019001-ralxw4ad	112	14	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	112	15	,	,	,
cord-019001-ralxw4ad	112	16	whereas	whereas	IN
cord-019001-ralxw4ad	112	17	the	the	DT
cord-019001-ralxw4ad	112	18	ET	ET	NNP
cord-019001-ralxw4ad	112	19	B	B	NNP
cord-019001-ralxw4ad	112	20	receptors	receptor	NNS
cord-019001-ralxw4ad	112	21	are	be	VBP
cord-019001-ralxw4ad	112	22	located	locate	VBN
cord-019001-ralxw4ad	112	23	on	on	IN
cord-019001-ralxw4ad	112	24	endothelial	endothelial	JJ
cord-019001-ralxw4ad	112	25	cells	cell	NNS
cord-019001-ralxw4ad	112	26	and	and	CC
cord-019001-ralxw4ad	112	27	smooth	smooth	JJ
cord-019001-ralxw4ad	112	28	muscle	muscle	NN
cord-019001-ralxw4ad	112	29	cells	cell	NNS
cord-019001-ralxw4ad	112	30	and	and	CC
cord-019001-ralxw4ad	112	31	thus	thus	RB
cord-019001-ralxw4ad	112	32	may	may	MD
cord-019001-ralxw4ad	112	33	mediate	mediate	VB
cord-019001-ralxw4ad	112	34	both	both	DT
cord-019001-ralxw4ad	112	35	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	112	36	and	and	CC
cord-019001-ralxw4ad	112	37	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	112	38	,	,	,
cord-019001-ralxw4ad	112	39	respectively	respectively	RB
cord-019001-ralxw4ad	112	40	.	.	.
cord-019001-ralxw4ad	113	1	Individual	individual	JJ
cord-019001-ralxw4ad	113	2	endothelins	endothelin	NNS
cord-019001-ralxw4ad	113	3	occur	occur	VBP
cord-019001-ralxw4ad	113	4	in	in	IN
cord-019001-ralxw4ad	113	5	low	low	JJ
cord-019001-ralxw4ad	113	6	levels	level	NNS
cord-019001-ralxw4ad	113	7	in	in	IN
cord-019001-ralxw4ad	113	8	the	the	DT
cord-019001-ralxw4ad	113	9	plasma	plasma	NN
cord-019001-ralxw4ad	113	10	,	,	,
cord-019001-ralxw4ad	113	11	generally	generally	RB
cord-019001-ralxw4ad	113	12	below	below	IN
cord-019001-ralxw4ad	113	13	their	-PRON-	PRP$
cord-019001-ralxw4ad	113	14	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	113	15	thresholds	threshold	NNS
cord-019001-ralxw4ad	113	16	.	.	.
cord-019001-ralxw4ad	114	1	This	this	DT
cord-019001-ralxw4ad	114	2	suggests	suggest	VBZ
cord-019001-ralxw4ad	114	3	that	that	IN
cord-019001-ralxw4ad	114	4	they	-PRON-	PRP
cord-019001-ralxw4ad	114	5	are	be	VBP
cord-019001-ralxw4ad	114	6	primarily	primarily	RB
cord-019001-ralxw4ad	114	7	effective	effective	JJ
cord-019001-ralxw4ad	114	8	at	at	IN
cord-019001-ralxw4ad	114	9	the	the	DT
cord-019001-ralxw4ad	114	10	local	local	JJ
cord-019001-ralxw4ad	114	11	site	site	NN
cord-019001-ralxw4ad	114	12	of	of	IN
cord-019001-ralxw4ad	114	13	release	release	NN
cord-019001-ralxw4ad	114	14	.	.	.
cord-019001-ralxw4ad	115	1	Even	even	RB
cord-019001-ralxw4ad	115	2	at	at	IN
cord-019001-ralxw4ad	115	3	these	these	DT
cord-019001-ralxw4ad	115	4	levels	level	NNS
cord-019001-ralxw4ad	115	5	,	,	,
cord-019001-ralxw4ad	115	6	they	-PRON-	PRP
cord-019001-ralxw4ad	115	7	may	may	MD
cord-019001-ralxw4ad	115	8	potentiate	potentiate	VB
cord-019001-ralxw4ad	115	9	the	the	DT
cord-019001-ralxw4ad	115	10	effects	effect	NNS
cord-019001-ralxw4ad	115	11	of	of	IN
cord-019001-ralxw4ad	115	12	other	other	JJ
cord-019001-ralxw4ad	115	13	vasoconstrictors	vasoconstrictor	NNS
cord-019001-ralxw4ad	115	14	,	,	,
cord-019001-ralxw4ad	115	15	such	such	JJ
cord-019001-ralxw4ad	115	16	as	as	IN
cord-019001-ralxw4ad	115	17	norepinephrine	norepinephrine	NN
cord-019001-ralxw4ad	115	18	and	and	CC
cord-019001-ralxw4ad	115	19	serotonin	serotonin	NN
cord-019001-ralxw4ad	115	20	[	[	-LRB-
cord-019001-ralxw4ad	115	21	95	95	CD
cord-019001-ralxw4ad	115	22	]	]	-RRB-
cord-019001-ralxw4ad	115	23	.	.	.
cord-019001-ralxw4ad	116	1	The	the	DT
cord-019001-ralxw4ad	116	2	role	role	NN
cord-019001-ralxw4ad	116	3	of	of	IN
cord-019001-ralxw4ad	116	4	endogenous	endogenous	JJ
cord-019001-ralxw4ad	116	5	ET-1	ET-1	NNP
cord-019001-ralxw4ad	116	6	in	in	IN
cord-019001-ralxw4ad	116	7	the	the	DT
cord-019001-ralxw4ad	116	8	regulation	regulation	NN
cord-019001-ralxw4ad	116	9	of	of	IN
cord-019001-ralxw4ad	116	10	normal	normal	JJ
cord-019001-ralxw4ad	116	11	vascular	vascular	JJ
cord-019001-ralxw4ad	116	12	tone	tone	NN
cord-019001-ralxw4ad	116	13	is	be	VBZ
cord-019001-ralxw4ad	116	14	unclear	unclear	JJ
cord-019001-ralxw4ad	116	15	at	at	IN
cord-019001-ralxw4ad	116	16	present	present	JJ
cord-019001-ralxw4ad	116	17	[	[	-LRB-
cord-019001-ralxw4ad	116	18	96	96	CD
cord-019001-ralxw4ad	116	19	]	]	-RRB-
cord-019001-ralxw4ad	116	20	.	.	.
cord-019001-ralxw4ad	117	1	Nevertheless	nevertheless	RB
cord-019001-ralxw4ad	117	2	,	,	,
cord-019001-ralxw4ad	117	3	alterations	alteration	NNS
cord-019001-ralxw4ad	117	4	in	in	IN
cord-019001-ralxw4ad	117	5	ET-1	ET-1	NNP
cord-019001-ralxw4ad	117	6	have	have	VBP
cord-019001-ralxw4ad	117	7	been	be	VBN
cord-019001-ralxw4ad	117	8	implicated	implicate	VBN
cord-019001-ralxw4ad	117	9	in	in	IN
cord-019001-ralxw4ad	117	10	the	the	DT
cord-019001-ralxw4ad	117	11	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	117	12	of	of	IN
cord-019001-ralxw4ad	117	13	a	a	DT
cord-019001-ralxw4ad	117	14	number	number	NN
cord-019001-ralxw4ad	117	15	of	of	IN
cord-019001-ralxw4ad	117	16	disease	disease	NN
cord-019001-ralxw4ad	117	17	states	state	NNS
cord-019001-ralxw4ad	117	18	,	,	,
cord-019001-ralxw4ad	117	19	including	include	VBG
cord-019001-ralxw4ad	117	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	117	21	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	117	22	disorders	disorder	NNS
cord-019001-ralxw4ad	117	23	,	,	,
cord-019001-ralxw4ad	117	24	and	and	CC
cord-019001-ralxw4ad	117	25	has	have	VBZ
cord-019001-ralxw4ad	117	26	been	be	VBN
cord-019001-ralxw4ad	117	27	implicated	implicate	VBN
cord-019001-ralxw4ad	117	28	in	in	IN
cord-019001-ralxw4ad	117	29	the	the	DT
cord-019001-ralxw4ad	117	30	so	so	RB
cord-019001-ralxw4ad	117	31	-	-	HYPH
cord-019001-ralxw4ad	117	32	called	call	VBN
cord-019001-ralxw4ad	117	33	rebound	rebound	NN
cord-019001-ralxw4ad	117	34	effect	effect	NN
cord-019001-ralxw4ad	117	35	of	of	IN
cord-019001-ralxw4ad	117	36	inhaled	inhale	VBN
cord-019001-ralxw4ad	117	37	NO	no	DT
cord-019001-ralxw4ad	117	38	[	[	-LRB-
cord-019001-ralxw4ad	117	39	24	24	CD
cord-019001-ralxw4ad	117	40	,	,	,
cord-019001-ralxw4ad	117	41	25	25	CD
cord-019001-ralxw4ad	117	42	,	,	,
cord-019001-ralxw4ad	117	43	54	54	CD
cord-019001-ralxw4ad	117	44	,	,	,
cord-019001-ralxw4ad	117	45	60	60	CD
cord-019001-ralxw4ad	117	46	,	,	,
cord-019001-ralxw4ad	117	47	97	97	CD
cord-019001-ralxw4ad	117	48	]	]	-RRB-
cord-019001-ralxw4ad	117	49	.	.	.
cord-019001-ralxw4ad	118	1	Endothelial	endothelial	NN
cord-019001-ralxw4ad	118	2	-	-	HYPH
cord-019001-ralxw4ad	118	3	derived	derive	VBN
cord-019001-ralxw4ad	118	4	hyperpolarizing	hyperpolarizing	NN
cord-019001-ralxw4ad	118	5	factor	factor	NN
cord-019001-ralxw4ad	118	6	(	(	-LRB-
cord-019001-ralxw4ad	118	7	EDHF	EDHF	NNP
cord-019001-ralxw4ad	118	8	)	)	-RRB-
cord-019001-ralxw4ad	118	9	,	,	,
cord-019001-ralxw4ad	118	10	a	a	DT
cord-019001-ralxw4ad	118	11	diffusible	diffusible	JJ
cord-019001-ralxw4ad	118	12	substance	substance	NN
cord-019001-ralxw4ad	118	13	that	that	WDT
cord-019001-ralxw4ad	118	14	causes	cause	VBZ
cord-019001-ralxw4ad	118	15	vascular	vascular	JJ
cord-019001-ralxw4ad	118	16	relaxation	relaxation	NN
cord-019001-ralxw4ad	118	17	by	by	IN
cord-019001-ralxw4ad	118	18	hyperpolarizing	hyperpolarize	VBG
cord-019001-ralxw4ad	118	19	the	the	DT
cord-019001-ralxw4ad	118	20	smooth	smooth	JJ
cord-019001-ralxw4ad	118	21	muscle	muscle	NN
cord-019001-ralxw4ad	118	22	cell	cell	NN
cord-019001-ralxw4ad	118	23	,	,	,
cord-019001-ralxw4ad	118	24	is	be	VBZ
cord-019001-ralxw4ad	118	25	another	another	DT
cord-019001-ralxw4ad	118	26	important	important	JJ
cord-019001-ralxw4ad	118	27	endothelial	endothelial	JJ
cord-019001-ralxw4ad	118	28	factor	factor	NN
cord-019001-ralxw4ad	118	29	.	.	.
cord-019001-ralxw4ad	119	1	Endothelial	endothelial	NN
cord-019001-ralxw4ad	119	2	-	-	HYPH
cord-019001-ralxw4ad	119	3	derived	derive	VBN
cord-019001-ralxw4ad	119	4	hyperpolarizing	hyperpolarizing	NN
cord-019001-ralxw4ad	119	5	factor	factor	NN
cord-019001-ralxw4ad	119	6	has	have	VBZ
cord-019001-ralxw4ad	119	7	not	not	RB
cord-019001-ralxw4ad	119	8	yet	yet	RB
cord-019001-ralxw4ad	119	9	been	be	VBN
cord-019001-ralxw4ad	119	10	identifi	identifi	VBN
cord-019001-ralxw4ad	119	11	ed	ed	NN
cord-019001-ralxw4ad	119	12	,	,	,
cord-019001-ralxw4ad	119	13	but	but	CC
cord-019001-ralxw4ad	119	14	current	current	JJ
cord-019001-ralxw4ad	119	15	evidence	evidence	NN
cord-019001-ralxw4ad	119	16	suggests	suggest	VBZ
cord-019001-ralxw4ad	119	17	that	that	IN
cord-019001-ralxw4ad	119	18	its	-PRON-	PRP$
cord-019001-ralxw4ad	119	19	action	action	NN
cord-019001-ralxw4ad	119	20	is	be	VBZ
cord-019001-ralxw4ad	119	21	dependent	dependent	JJ
cord-019001-ralxw4ad	119	22	on	on	IN
cord-019001-ralxw4ad	119	23	K	k	NN
cord-019001-ralxw4ad	119	24	+	+	CC
cord-019001-ralxw4ad	119	25	channels	channel	NNS
cord-019001-ralxw4ad	119	26	[	[	-LRB-
cord-019001-ralxw4ad	119	27	97	97	CD
cord-019001-ralxw4ad	119	28	]	]	-RRB-
cord-019001-ralxw4ad	119	29	.	.	.
cord-019001-ralxw4ad	120	1	Activation	activation	NN
cord-019001-ralxw4ad	120	2	of	of	IN
cord-019001-ralxw4ad	120	3	potassium	potassium	NN
cord-019001-ralxw4ad	120	4	channels	channel	NNS
cord-019001-ralxw4ad	120	5	in	in	IN
cord-019001-ralxw4ad	120	6	the	the	DT
cord-019001-ralxw4ad	120	7	vascular	vascular	JJ
cord-019001-ralxw4ad	120	8	smooth	smooth	JJ
cord-019001-ralxw4ad	120	9	muscle	muscle	NN
cord-019001-ralxw4ad	120	10	results	result	NNS
cord-019001-ralxw4ad	120	11	in	in	IN
cord-019001-ralxw4ad	120	12	cell	cell	NN
cord-019001-ralxw4ad	120	13	membrane	membrane	NN
cord-019001-ralxw4ad	120	14	hyperpolarization	hyperpolarization	NN
cord-019001-ralxw4ad	120	15	,	,	,
cord-019001-ralxw4ad	120	16	closure	closure	NN
cord-019001-ralxw4ad	120	17	of	of	IN
cord-019001-ralxw4ad	120	18	voltage	voltage	NN
cord-019001-ralxw4ad	120	19	-	-	HYPH
cord-019001-ralxw4ad	120	20	dependent	dependent	JJ
cord-019001-ralxw4ad	120	21	calcium	calcium	NN
cord-019001-ralxw4ad	120	22	channels	channel	NNS
cord-019001-ralxw4ad	120	23	,	,	,
cord-019001-ralxw4ad	120	24	and	and	CC
cord-019001-ralxw4ad	120	25	ultimately	ultimately	RB
cord-019001-ralxw4ad	120	26	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	120	27	.	.	.
cord-019001-ralxw4ad	121	1	Potassium	potassium	NN
cord-019001-ralxw4ad	121	2	channels	channel	NNS
cord-019001-ralxw4ad	121	3	are	be	VBP
cord-019001-ralxw4ad	121	4	also	also	RB
cord-019001-ralxw4ad	121	5	present	present	JJ
cord-019001-ralxw4ad	121	6	in	in	IN
cord-019001-ralxw4ad	121	7	endothelial	endothelial	JJ
cord-019001-ralxw4ad	121	8	cells	cell	NNS
cord-019001-ralxw4ad	121	9	.	.	.
cord-019001-ralxw4ad	122	1	Activation	activation	NN
cord-019001-ralxw4ad	122	2	within	within	IN
cord-019001-ralxw4ad	122	3	the	the	DT
cord-019001-ralxw4ad	122	4	endothelium	endothelium	NN
cord-019001-ralxw4ad	122	5	results	result	NNS
cord-019001-ralxw4ad	122	6	in	in	IN
cord-019001-ralxw4ad	122	7	changes	change	NNS
cord-019001-ralxw4ad	122	8	in	in	IN
cord-019001-ralxw4ad	122	9	calcium	calcium	NN
cord-019001-ralxw4ad	122	10	fl	fl	NNP
cord-019001-ralxw4ad	122	11	ux	ux	NNP
cord-019001-ralxw4ad	122	12	and	and	CC
cord-019001-ralxw4ad	122	13	may	may	MD
cord-019001-ralxw4ad	122	14	be	be	VB
cord-019001-ralxw4ad	122	15	important	important	JJ
cord-019001-ralxw4ad	122	16	in	in	IN
cord-019001-ralxw4ad	122	17	the	the	DT
cord-019001-ralxw4ad	122	18	release	release	NN
cord-019001-ralxw4ad	122	19	of	of	IN
cord-019001-ralxw4ad	122	20	NO	NO	NNP
cord-019001-ralxw4ad	122	21	,	,	,
cord-019001-ralxw4ad	122	22	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	122	23	,	,	,
cord-019001-ralxw4ad	122	24	and	and	CC
cord-019001-ralxw4ad	122	25	EDHF	EDHF	NNP
cord-019001-ralxw4ad	122	26	.	.	.
cord-019001-ralxw4ad	123	1	Potassium	potassium	NN
cord-019001-ralxw4ad	123	2	channel	channel	NN
cord-019001-ralxw4ad	123	3	subtypes	subtype	NNS
cord-019001-ralxw4ad	123	4	include	include	VBP
cord-019001-ralxw4ad	123	5	ATP	ATP	NNP
cord-019001-ralxw4ad	123	6	-	-	HYPH
cord-019001-ralxw4ad	123	7	sensitive	sensitive	JJ
cord-019001-ralxw4ad	123	8	K	K	NNP
cord-019001-ralxw4ad	123	9	+	+	CC
cord-019001-ralxw4ad	123	10	channels	channel	NNS
cord-019001-ralxw4ad	123	11	,	,	,
cord-019001-ralxw4ad	124	1	Ca	ca	RB
cord-019001-ralxw4ad	124	2	2	2	CD
cord-019001-ralxw4ad	125	1	+	+	CC
cord-019001-ralxw4ad	126	1	-dependent	-dependent	JJ
cord-019001-ralxw4ad	126	2	K	K	NNP
cord-019001-ralxw4ad	126	3	+	+	CC
cord-019001-ralxw4ad	126	4	channels	channel	NNS
cord-019001-ralxw4ad	126	5	,	,	,
cord-019001-ralxw4ad	126	6	voltage	voltage	NN
cord-019001-ralxw4ad	126	7	-	-	HYPH
cord-019001-ralxw4ad	126	8	dependent	dependent	JJ
cord-019001-ralxw4ad	126	9	K	k	NN
cord-019001-ralxw4ad	126	10	+	+	CC
cord-019001-ralxw4ad	126	11	channels	channel	NNS
cord-019001-ralxw4ad	126	12	,	,	,
cord-019001-ralxw4ad	126	13	and	and	CC
cord-019001-ralxw4ad	126	14	inward	inward	JJ
cord-019001-ralxw4ad	126	15	-	-	HYPH
cord-019001-ralxw4ad	126	16	rectifi	rectifi	JJ
cord-019001-ralxw4ad	127	1	er	er	UH
cord-019001-ralxw4ad	127	2	K	K	NNP
cord-019001-ralxw4ad	127	3	+	+	CC
cord-019001-ralxw4ad	127	4	channels	channel	NNS
cord-019001-ralxw4ad	127	5	[	[	-LRB-
cord-019001-ralxw4ad	127	6	97	97	CD
cord-019001-ralxw4ad	127	7	]	]	-RRB-
cord-019001-ralxw4ad	127	8	.	.	.
cord-019001-ralxw4ad	128	1	The	the	DT
cord-019001-ralxw4ad	128	2	breakdown	breakdown	NN
cord-019001-ralxw4ad	128	3	of	of	IN
cord-019001-ralxw4ad	128	4	phospholipids	phospholipid	NNS
cord-019001-ralxw4ad	128	5	within	within	IN
cord-019001-ralxw4ad	128	6	vascular	vascular	JJ
cord-019001-ralxw4ad	128	7	endothelial	endothelial	JJ
cord-019001-ralxw4ad	128	8	cells	cell	NNS
cord-019001-ralxw4ad	128	9	results	result	NNS
cord-019001-ralxw4ad	128	10	in	in	IN
cord-019001-ralxw4ad	128	11	the	the	DT
cord-019001-ralxw4ad	128	12	production	production	NN
cord-019001-ralxw4ad	128	13	of	of	IN
cord-019001-ralxw4ad	128	14	the	the	DT
cord-019001-ralxw4ad	128	15	important	important	JJ
cord-019001-ralxw4ad	128	16	byproducts	byproduct	NNS
cord-019001-ralxw4ad	128	17	of	of	IN
cord-019001-ralxw4ad	128	18	arachidonic	arachidonic	JJ
cord-019001-ralxw4ad	128	19	acid	acid	NN
cord-019001-ralxw4ad	128	20	,	,	,
cord-019001-ralxw4ad	128	21	including	include	VBG
cord-019001-ralxw4ad	128	22	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	128	23	(	(	-LRB-
cord-019001-ralxw4ad	128	24	PGI	PGI	NNP
cord-019001-ralxw4ad	128	25	2	2	CD
cord-019001-ralxw4ad	128	26	)	)	-RRB-
cord-019001-ralxw4ad	128	27	and	and	CC
cord-019001-ralxw4ad	128	28	thromboxane	thromboxane	NN
cord-019001-ralxw4ad	128	29	(	(	-LRB-
cord-019001-ralxw4ad	128	30	TXA	TXA	NNP
cord-019001-ralxw4ad	128	31	2	2	CD
cord-019001-ralxw4ad	128	32	)	)	-RRB-
cord-019001-ralxw4ad	128	33	.	.	.
cord-019001-ralxw4ad	129	1	Prostacyclin	Prostacyclin	NNP
cord-019001-ralxw4ad	129	2	activates	activate	VBZ
cord-019001-ralxw4ad	129	3	adenylate	adenylate	NN
cord-019001-ralxw4ad	129	4	cyclase	cyclase	NN
cord-019001-ralxw4ad	129	5	,	,	,
cord-019001-ralxw4ad	129	6	resulting	result	VBG
cord-019001-ralxw4ad	129	7	in	in	IN
cord-019001-ralxw4ad	129	8	increased	increase	VBN
cord-019001-ralxw4ad	129	9	cAMP	camp	NN
cord-019001-ralxw4ad	129	10	production	production	NN
cord-019001-ralxw4ad	129	11	and	and	CC
cord-019001-ralxw4ad	129	12	subsequent	subsequent	JJ
cord-019001-ralxw4ad	129	13	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	129	14	,	,	,
cord-019001-ralxw4ad	129	15	whereas	whereas	IN
cord-019001-ralxw4ad	129	16	TXA	TXA	NNP
cord-019001-ralxw4ad	129	17	2	2	CD
cord-019001-ralxw4ad	129	18	results	result	NNS
cord-019001-ralxw4ad	129	19	in	in	IN
cord-019001-ralxw4ad	129	20	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	129	21	via	via	IN
cord-019001-ralxw4ad	129	22	phospholipase	phospholipase	NN
cord-019001-ralxw4ad	129	23	C	C	NNP
cord-019001-ralxw4ad	129	24	signaling	signaling	NN
cord-019001-ralxw4ad	129	25	.	.	.
cord-019001-ralxw4ad	130	1	Other	other	JJ
cord-019001-ralxw4ad	130	2	prostaglandins	prostaglandin	NNS
cord-019001-ralxw4ad	130	3	and	and	CC
cord-019001-ralxw4ad	130	4	leukotrienes	leukotriene	NNS
cord-019001-ralxw4ad	130	5	also	also	RB
cord-019001-ralxw4ad	130	6	have	have	VBP
cord-019001-ralxw4ad	130	7	potent	potent	JJ
cord-019001-ralxw4ad	130	8	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	130	9	properties	property	NNS
cord-019001-ralxw4ad	130	10	.	.	.
cord-019001-ralxw4ad	131	1	Increasing	increase	VBG
cord-019001-ralxw4ad	131	2	evidence	evidence	NN
cord-019001-ralxw4ad	131	3	suggests	suggest	VBZ
cord-019001-ralxw4ad	131	4	that	that	IN
cord-019001-ralxw4ad	131	5	endothelial	endothelial	JJ
cord-019001-ralxw4ad	131	6	injury	injury	NN
cord-019001-ralxw4ad	131	7	and	and	CC
cord-019001-ralxw4ad	131	8	the	the	DT
cord-019001-ralxw4ad	131	9	resulting	result	VBG
cord-019001-ralxw4ad	131	10	alteration	alteration	NN
cord-019001-ralxw4ad	131	11	in	in	IN
cord-019001-ralxw4ad	131	12	the	the	DT
cord-019001-ralxw4ad	131	13	balance	balance	NN
cord-019001-ralxw4ad	131	14	of	of	IN
cord-019001-ralxw4ad	131	15	these	these	DT
cord-019001-ralxw4ad	131	16	and	and	CC
cord-019001-ralxw4ad	131	17	other	other	JJ
cord-019001-ralxw4ad	131	18	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	131	19	substances	substance	NNS
cord-019001-ralxw4ad	131	20	has	have	VBZ
cord-019001-ralxw4ad	131	21	a	a	DT
cord-019001-ralxw4ad	131	22	signifi	signifi	NN
cord-019001-ralxw4ad	132	1	ca	can	MD
cord-019001-ralxw4ad	132	2	nt	not	RB
cord-019001-ralxw4ad	132	3	role	role	VB
cord-019001-ralxw4ad	132	4	in	in	IN
cord-019001-ralxw4ad	132	5	the	the	DT
cord-019001-ralxw4ad	132	6	development	development	NN
cord-019001-ralxw4ad	132	7	of	of	IN
cord-019001-ralxw4ad	132	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	132	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	132	10	and	and	CC
cord-019001-ralxw4ad	132	11	increased	increase	VBN
cord-019001-ralxw4ad	132	12	vascular	vascular	JJ
cord-019001-ralxw4ad	132	13	reactivity	reactivity	NN
cord-019001-ralxw4ad	132	14	[	[	-LRB-
cord-019001-ralxw4ad	132	15	22	22	CD
cord-019001-ralxw4ad	132	16	,	,	,
cord-019001-ralxw4ad	132	17	98	98	CD
cord-019001-ralxw4ad	132	18	,	,	,
cord-019001-ralxw4ad	132	19	99	99	CD
cord-019001-ralxw4ad	132	20	]	]	-RRB-
cord-019001-ralxw4ad	132	21	.	.	.
cord-019001-ralxw4ad	133	1	Support	support	NN
cord-019001-ralxw4ad	133	2	for	for	IN
cord-019001-ralxw4ad	133	3	this	this	DT
cord-019001-ralxw4ad	133	4	hypothesis	hypothesis	NN
cord-019001-ralxw4ad	133	5	is	be	VBZ
cord-019001-ralxw4ad	133	6	strengthened	strengthen	VBN
cord-019001-ralxw4ad	133	7	by	by	IN
cord-019001-ralxw4ad	133	8	observations	observation	NNS
cord-019001-ralxw4ad	133	9	that	that	IN
cord-019001-ralxw4ad	133	10	endothelial	endothelial	JJ
cord-019001-ralxw4ad	133	11	injury	injury	NN
cord-019001-ralxw4ad	133	12	precedes	precede	VBZ
cord-019001-ralxw4ad	133	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	133	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	133	15	and	and	CC
cord-019001-ralxw4ad	133	16	its	-PRON-	PRP$
cord-019001-ralxw4ad	133	17	associated	associated	JJ
cord-019001-ralxw4ad	133	18	vascular	vascular	JJ
cord-019001-ralxw4ad	133	19	remodeling	remodeling	NN
cord-019001-ralxw4ad	133	20	in	in	IN
cord-019001-ralxw4ad	133	21	several	several	JJ
cord-019001-ralxw4ad	133	22	animal	animal	NN
cord-019001-ralxw4ad	133	23	models	model	NNS
cord-019001-ralxw4ad	133	24	of	of	IN
cord-019001-ralxw4ad	133	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	133	26	hypertension	hypertension	NN
cord-019001-ralxw4ad	133	27	[	[	-LRB-
cord-019001-ralxw4ad	133	28	61	61	CD
cord-019001-ralxw4ad	133	29	,	,	,
cord-019001-ralxw4ad	133	30	100	100	CD
cord-019001-ralxw4ad	133	31	]	]	-RRB-
cord-019001-ralxw4ad	133	32	.	.	.
cord-019001-ralxw4ad	134	1	In	in	IN
cord-019001-ralxw4ad	134	2	humans	human	NNS
cord-019001-ralxw4ad	134	3	,	,	,
cord-019001-ralxw4ad	134	4	endothelial	endothelial	JJ
cord-019001-ralxw4ad	134	5	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	134	6	,	,	,
cord-019001-ralxw4ad	134	7	including	include	VBG
cord-019001-ralxw4ad	134	8	histologic	histologic	JJ
cord-019001-ralxw4ad	134	9	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	134	10	of	of	IN
cord-019001-ralxw4ad	134	11	the	the	DT
cord-019001-ralxw4ad	134	12	endothelium	endothelium	NN
cord-019001-ralxw4ad	134	13	,	,	,
cord-019001-ralxw4ad	134	14	impairment	impairment	NN
cord-019001-ralxw4ad	134	15	of	of	IN
cord-019001-ralxw4ad	134	16	endothelium	endothelium	NN
cord-019001-ralxw4ad	134	17	-	-	HYPH
cord-019001-ralxw4ad	134	18	dependent	dependent	JJ
cord-019001-ralxw4ad	134	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	134	20	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	134	21	,	,	,
cord-019001-ralxw4ad	134	22	and	and	CC
cord-019001-ralxw4ad	134	23	increased	increase	VBN
cord-019001-ralxw4ad	134	24	plasma	plasma	NN
cord-019001-ralxw4ad	134	25	ET-1	ET-1	NNP
cord-019001-ralxw4ad	134	26	concentrations	concentration	NNS
cord-019001-ralxw4ad	134	27	have	have	VBP
cord-019001-ralxw4ad	134	28	been	be	VBN
cord-019001-ralxw4ad	134	29	described	describe	VBN
cord-019001-ralxw4ad	134	30	in	in	IN
cord-019001-ralxw4ad	134	31	children	child	NNS
cord-019001-ralxw4ad	134	32	with	with	IN
cord-019001-ralxw4ad	134	33	congenital	congenital	JJ
cord-019001-ralxw4ad	134	34	heart	heart	NN
cord-019001-ralxw4ad	134	35	defects	defect	NNS
cord-019001-ralxw4ad	134	36	and	and	CC
cord-019001-ralxw4ad	134	37	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	134	38	hypertension	hypertension	NN
cord-019001-ralxw4ad	134	39	before	before	IN
cord-019001-ralxw4ad	134	40	the	the	DT
cord-019001-ralxw4ad	134	41	development	development	NN
cord-019001-ralxw4ad	134	42	of	of	IN
cord-019001-ralxw4ad	134	43	signifi	signifi	NNP
cord-019001-ralxw4ad	135	1	ca	can	MD
cord-019001-ralxw4ad	135	2	nt	not	RB
cord-019001-ralxw4ad	135	3	vascular	vascular	JJ
cord-019001-ralxw4ad	135	4	remodeling	remodeling	NN
cord-019001-ralxw4ad	135	5	[	[	-LRB-
cord-019001-ralxw4ad	135	6	22	22	CD
cord-019001-ralxw4ad	135	7	,	,	,
cord-019001-ralxw4ad	135	8	98	98	CD
cord-019001-ralxw4ad	135	9	,	,	,
cord-019001-ralxw4ad	135	10	101	101	CD
cord-019001-ralxw4ad	135	11	]	]	-RRB-
cord-019001-ralxw4ad	135	12	.	.	.
cord-019001-ralxw4ad	136	1	In	in	IN
cord-019001-ralxw4ad	136	2	addition	addition	NN
cord-019001-ralxw4ad	136	3	,	,	,
cord-019001-ralxw4ad	136	4	neonates	neonate	NNS
cord-019001-ralxw4ad	136	5	with	with	IN
cord-019001-ralxw4ad	136	6	PPHN	PPHN	NNS
cord-019001-ralxw4ad	136	7	and	and	CC
cord-019001-ralxw4ad	136	8	adults	adult	NNS
cord-019001-ralxw4ad	136	9	with	with	IN
cord-019001-ralxw4ad	136	10	advanced	advanced	JJ
cord-019001-ralxw4ad	136	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	136	12	vascular	vascular	JJ
cord-019001-ralxw4ad	136	13	disease	disease	NN
cord-019001-ralxw4ad	136	14	have	have	VBP
cord-019001-ralxw4ad	136	15	evidence	evidence	NN
cord-019001-ralxw4ad	136	16	of	of	IN
cord-019001-ralxw4ad	136	17	endothelial	endothelial	JJ
cord-019001-ralxw4ad	136	18	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	136	19	,	,	,
cord-019001-ralxw4ad	136	20	impairment	impairment	NN
cord-019001-ralxw4ad	136	21	of	of	IN
cord-019001-ralxw4ad	136	22	endothelium	endothelium	NN
cord-019001-ralxw4ad	136	23	-	-	HYPH
cord-019001-ralxw4ad	136	24	dependent	dependent	JJ
cord-019001-ralxw4ad	136	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	136	26	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	136	27	,	,	,
cord-019001-ralxw4ad	136	28	increased	increase	VBN
cord-019001-ralxw4ad	136	29	plasma	plasma	NN
cord-019001-ralxw4ad	136	30	ET-1	ET-1	NNP
cord-019001-ralxw4ad	136	31	concentrations	concentration	NNS
cord-019001-ralxw4ad	136	32	,	,	,
cord-019001-ralxw4ad	136	33	and	and	CC
cord-019001-ralxw4ad	136	34	decreased	decrease	VBD
cord-019001-ralxw4ad	136	35	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	136	36	production	production	NN
cord-019001-ralxw4ad	136	37	[	[	-LRB-
cord-019001-ralxw4ad	136	38	23	23	CD
cord-019001-ralxw4ad	136	39	,	,	,
cord-019001-ralxw4ad	136	40	24	24	CD
cord-019001-ralxw4ad	136	41	,	,	,
cord-019001-ralxw4ad	136	42	62	62	CD
cord-019001-ralxw4ad	136	43	,	,	,
cord-019001-ralxw4ad	136	44	99	99	CD
cord-019001-ralxw4ad	136	45	]	]	-RRB-
cord-019001-ralxw4ad	136	46	.	.	.
cord-019001-ralxw4ad	137	1	The	the	DT
cord-019001-ralxw4ad	137	2	mechanism	mechanism	NN
cord-019001-ralxw4ad	137	3	of	of	IN
cord-019001-ralxw4ad	137	4	injury	injury	NN
cord-019001-ralxw4ad	137	5	to	to	IN
cord-019001-ralxw4ad	137	6	the	the	DT
cord-019001-ralxw4ad	137	7	vascular	vascular	JJ
cord-019001-ralxw4ad	137	8	endothelium	endothelium	NN
cord-019001-ralxw4ad	137	9	is	be	VBZ
cord-019001-ralxw4ad	137	10	unclear	unclear	JJ
cord-019001-ralxw4ad	137	11	but	but	CC
cord-019001-ralxw4ad	137	12	is	be	VBZ
cord-019001-ralxw4ad	137	13	likely	likely	RB
cord-019001-ralxw4ad	137	14	multifactorial	multifactorial	JJ
cord-019001-ralxw4ad	137	15	and	and	CC
cord-019001-ralxw4ad	137	16	in	in	IN
cord-019001-ralxw4ad	137	17	part	part	NN
cord-019001-ralxw4ad	137	18	dependent	dependent	JJ
cord-019001-ralxw4ad	137	19	on	on	IN
cord-019001-ralxw4ad	137	20	the	the	DT
cord-019001-ralxw4ad	137	21	etiology	etiology	NN
cord-019001-ralxw4ad	137	22	of	of	IN
cord-019001-ralxw4ad	137	23	the	the	DT
cord-019001-ralxw4ad	137	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	137	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	137	26	.	.	.
cord-019001-ralxw4ad	138	1	For	for	IN
cord-019001-ralxw4ad	138	2	example	example	NN
cord-019001-ralxw4ad	138	3	,	,	,
cord-019001-ralxw4ad	138	4	in	in	IN
cord-019001-ralxw4ad	138	5	children	child	NNS
cord-019001-ralxw4ad	138	6	with	with	IN
cord-019001-ralxw4ad	138	7	congenital	congenital	JJ
cord-019001-ralxw4ad	138	8	heart	heart	NN
cord-019001-ralxw4ad	138	9	disease	disease	NN
cord-019001-ralxw4ad	138	10	and	and	CC
cord-019001-ralxw4ad	138	11	increased	increase	VBN
cord-019001-ralxw4ad	138	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	138	13	blood	blood	NN
cord-019001-ralxw4ad	138	14	fl	fl	NNP
cord-019001-ralxw4ad	138	15	ow	ow	NNP
cord-019001-ralxw4ad	138	16	,	,	,
cord-019001-ralxw4ad	138	17	the	the	DT
cord-019001-ralxw4ad	138	18	initiating	initiate	VBG
cord-019001-ralxw4ad	138	19	endothelial	endothelial	JJ
cord-019001-ralxw4ad	138	20	injury	injury	NN
cord-019001-ralxw4ad	138	21	is	be	VBZ
cord-019001-ralxw4ad	138	22	likely	likely	RB
cord-019001-ralxw4ad	138	23	mediated	mediate	VBN
cord-019001-ralxw4ad	138	24	by	by	IN
cord-019001-ralxw4ad	138	25	increased	increase	VBN
cord-019001-ralxw4ad	138	26	shear	shear	NN
cord-019001-ralxw4ad	138	27	stress	stress	NN
cord-019001-ralxw4ad	138	28	.	.	.
cord-019001-ralxw4ad	139	1	However	however	RB
cord-019001-ralxw4ad	139	2	,	,	,
cord-019001-ralxw4ad	139	3	once	once	RB
cord-019001-ralxw4ad	139	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	139	5	arterial	arterial	JJ
cord-019001-ralxw4ad	139	6	pressure	pressure	NN
cord-019001-ralxw4ad	139	7	is	be	VBZ
cord-019001-ralxw4ad	139	8	elevated	elevate	VBN
cord-019001-ralxw4ad	139	9	,	,	,
cord-019001-ralxw4ad	139	10	shear	shear	NN
cord-019001-ralxw4ad	139	11	stress	stress	NN
cord-019001-ralxw4ad	139	12	-	-	HYPH
cord-019001-ralxw4ad	139	13	mediated	mediate	VBN
cord-019001-ralxw4ad	139	14	endothelial	endothelial	JJ
cord-019001-ralxw4ad	139	15	injury	injury	NN
cord-019001-ralxw4ad	139	16	appears	appear	VBZ
cord-019001-ralxw4ad	139	17	to	to	TO
cord-019001-ralxw4ad	139	18	promote	promote	VB
cord-019001-ralxw4ad	139	19	the	the	DT
cord-019001-ralxw4ad	139	20	progression	progression	NN
cord-019001-ralxw4ad	139	21	of	of	IN
cord-019001-ralxw4ad	139	22	the	the	DT
cord-019001-ralxw4ad	139	23	disease	disease	NN
cord-019001-ralxw4ad	139	24	,	,	,
cord-019001-ralxw4ad	139	25	independent	independent	JJ
cord-019001-ralxw4ad	139	26	of	of	IN
cord-019001-ralxw4ad	139	27	the	the	DT
cord-019001-ralxw4ad	139	28	underlying	underlie	VBG
cord-019001-ralxw4ad	139	29	etiology	etiology	NN
cord-019001-ralxw4ad	139	30	.	.	.
cord-019001-ralxw4ad	140	1	Finally	finally	RB
cord-019001-ralxw4ad	140	2	,	,	,
cord-019001-ralxw4ad	140	3	a	a	DT
cord-019001-ralxw4ad	140	4	genetic	genetic	JJ
cord-019001-ralxw4ad	140	5	disposition	disposition	NN
cord-019001-ralxw4ad	140	6	appears	appear	VBZ
cord-019001-ralxw4ad	140	7	to	to	TO
cord-019001-ralxw4ad	140	8	be	be	VB
cord-019001-ralxw4ad	140	9	important	important	JJ
cord-019001-ralxw4ad	140	10	in	in	IN
cord-019001-ralxw4ad	140	11	some	some	DT
cord-019001-ralxw4ad	140	12	subtypes	subtype	NNS
cord-019001-ralxw4ad	140	13	of	of	IN
cord-019001-ralxw4ad	140	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	140	15	vascular	vascular	JJ
cord-019001-ralxw4ad	140	16	disease	disease	NN
cord-019001-ralxw4ad	140	17	and	and	CC
cord-019001-ralxw4ad	140	18	remains	remain	VBZ
cord-019001-ralxw4ad	140	19	an	an	DT
cord-019001-ralxw4ad	140	20	area	area	NN
cord-019001-ralxw4ad	140	21	of	of	IN
cord-019001-ralxw4ad	140	22	active	active	JJ
cord-019001-ralxw4ad	140	23	research	research	NN
cord-019001-ralxw4ad	140	24	.	.	.
cord-019001-ralxw4ad	141	1	For	for	IN
cord-019001-ralxw4ad	141	2	example	example	NN
cord-019001-ralxw4ad	141	3	,	,	,
cord-019001-ralxw4ad	141	4	up	up	IN
cord-019001-ralxw4ad	141	5	to	to	TO
cord-019001-ralxw4ad	141	6	60	60	CD
cord-019001-ralxw4ad	141	7	%	%	NN
cord-019001-ralxw4ad	141	8	of	of	IN
cord-019001-ralxw4ad	141	9	patients	patient	NNS
cord-019001-ralxw4ad	141	10	with	with	IN
cord-019001-ralxw4ad	141	11	familial	familial	JJ
cord-019001-ralxw4ad	141	12	idiopathic	idiopathic	JJ
cord-019001-ralxw4ad	141	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	141	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	141	15	have	have	VBP
cord-019001-ralxw4ad	141	16	mutations	mutation	NNS
cord-019001-ralxw4ad	141	17	resulting	result	VBG
cord-019001-ralxw4ad	141	18	in	in	IN
cord-019001-ralxw4ad	141	19	the	the	DT
cord-019001-ralxw4ad	141	20	loss	loss	NN
cord-019001-ralxw4ad	141	21	of	of	IN
cord-019001-ralxw4ad	141	22	function	function	NN
cord-019001-ralxw4ad	141	23	of	of	IN
cord-019001-ralxw4ad	141	24	bone	bone	NN
cord-019001-ralxw4ad	141	25	morphogenetic	morphogenetic	JJ
cord-019001-ralxw4ad	141	26	protein	protein	NN
cord-019001-ralxw4ad	141	27	receptor	receptor	NN
cord-019001-ralxw4ad	141	28	II	II	NNP
cord-019001-ralxw4ad	141	29	[	[	-LRB-
cord-019001-ralxw4ad	141	30	102	102	CD
cord-019001-ralxw4ad	141	31	]	]	-RRB-
cord-019001-ralxw4ad	141	32	[	[	-LRB-
cord-019001-ralxw4ad	141	33	103	103	CD
cord-019001-ralxw4ad	141	34	]	]	-RRB-
cord-019001-ralxw4ad	141	35	[	[	-LRB-
cord-019001-ralxw4ad	141	36	104	104	CD
cord-019001-ralxw4ad	141	37	]	]	-RRB-
cord-019001-ralxw4ad	141	38	[	[	-LRB-
cord-019001-ralxw4ad	141	39	105	105	CD
cord-019001-ralxw4ad	141	40	]	]	-RRB-
cord-019001-ralxw4ad	141	41	.	.	.
cord-019001-ralxw4ad	142	1	Following	follow	VBG
cord-019001-ralxw4ad	142	2	an	an	DT
cord-019001-ralxw4ad	142	3	initial	initial	JJ
cord-019001-ralxw4ad	142	4	endothelial	endothelial	JJ
cord-019001-ralxw4ad	142	5	injury	injury	NN
cord-019001-ralxw4ad	142	6	,	,	,
cord-019001-ralxw4ad	142	7	smooth	smooth	JJ
cord-019001-ralxw4ad	142	8	muscle	muscle	NN
cord-019001-ralxw4ad	142	9	proliferation	proliferation	NN
cord-019001-ralxw4ad	142	10	and	and	CC
cord-019001-ralxw4ad	142	11	progressive	progressive	JJ
cord-019001-ralxw4ad	142	12	structural	structural	JJ
cord-019001-ralxw4ad	142	13	remodeling	remodeling	NN
cord-019001-ralxw4ad	142	14	occurs	occur	VBZ
cord-019001-ralxw4ad	142	15	.	.	.
cord-019001-ralxw4ad	143	1	The	the	DT
cord-019001-ralxw4ad	143	2	progression	progression	NN
cord-019001-ralxw4ad	143	3	of	of	IN
cord-019001-ralxw4ad	143	4	anatomic	anatomic	JJ
cord-019001-ralxw4ad	143	5	changes	change	NNS
cord-019001-ralxw4ad	143	6	is	be	VBZ
cord-019001-ralxw4ad	143	7	best	well	RBS
cord-019001-ralxw4ad	143	8	characterized	characterize	VBN
cord-019001-ralxw4ad	143	9	in	in	IN
cord-019001-ralxw4ad	143	10	congenital	congenital	JJ
cord-019001-ralxw4ad	143	11	heart	heart	NN
cord-019001-ralxw4ad	143	12	disease	disease	NN
cord-019001-ralxw4ad	143	13	(	(	-LRB-
cord-019001-ralxw4ad	143	14	see	see	VB
cord-019001-ralxw4ad	143	15	later	later	RB
cord-019001-ralxw4ad	143	16	discussion	discussion	NN
cord-019001-ralxw4ad	143	17	)	)	-RRB-
cord-019001-ralxw4ad	144	1	[	[	-LRB-
cord-019001-ralxw4ad	144	2	106	106	CD
cord-019001-ralxw4ad	144	3	]	]	-RRB-
cord-019001-ralxw4ad	144	4	[	[	-LRB-
cord-019001-ralxw4ad	144	5	107	107	CD
cord-019001-ralxw4ad	144	6	]	]	-RRB-
cord-019001-ralxw4ad	145	1	[	[	-LRB-
cord-019001-ralxw4ad	145	2	108	108	CD
cord-019001-ralxw4ad	145	3	]	]	-RRB-
cord-019001-ralxw4ad	145	4	[	[	-LRB-
cord-019001-ralxw4ad	145	5	109	109	CD
cord-019001-ralxw4ad	145	6	]	]	-RRB-
cord-019001-ralxw4ad	145	7	.	.	.
cord-019001-ralxw4ad	146	1	However	however	RB
cord-019001-ralxw4ad	146	2	,	,	,
cord-019001-ralxw4ad	146	3	regardless	regardless	RB
cord-019001-ralxw4ad	146	4	of	of	IN
cord-019001-ralxw4ad	146	5	the	the	DT
cord-019001-ralxw4ad	146	6	etiology	etiology	NN
cord-019001-ralxw4ad	146	7	,	,	,
cord-019001-ralxw4ad	146	8	advanced	advanced	JJ
cord-019001-ralxw4ad	146	9	disease	disease	NN
cord-019001-ralxw4ad	146	10	is	be	VBZ
cord-019001-ralxw4ad	146	11	characterized	characterize	VBN
cord-019001-ralxw4ad	146	12	by	by	IN
cord-019001-ralxw4ad	146	13	medial	medial	JJ
cord-019001-ralxw4ad	146	14	hypertrophy	hypertrophy	NN
cord-019001-ralxw4ad	146	15	,	,	,
cord-019001-ralxw4ad	146	16	intimal	intimal	JJ
cord-019001-ralxw4ad	146	17	hyperplasia	hyperplasia	NN
cord-019001-ralxw4ad	146	18	,	,	,
cord-019001-ralxw4ad	146	19	angiomatoid	angiomatoid	NNP
cord-019001-ralxw4ad	146	20	formation	formation	NN
cord-019001-ralxw4ad	146	21	,	,	,
cord-019001-ralxw4ad	146	22	in	in	IN
cord-019001-ralxw4ad	146	23	situ	situ	FW
cord-019001-ralxw4ad	146	24	thrombi	thrombi	NNP
cord-019001-ralxw4ad	146	25	,	,	,
cord-019001-ralxw4ad	146	26	and	and	CC
cord-019001-ralxw4ad	146	27	eventual	eventual	JJ
cord-019001-ralxw4ad	146	28	vascular	vascular	JJ
cord-019001-ralxw4ad	146	29	obliteration	obliteration	NN
cord-019001-ralxw4ad	146	30	.	.	.
cord-019001-ralxw4ad	147	1	If	if	IN
cord-019001-ralxw4ad	147	2	the	the	DT
cord-019001-ralxw4ad	147	3	underlying	underlying	JJ
cord-019001-ralxw4ad	147	4	stress	stress	NN
cord-019001-ralxw4ad	147	5	remains	remain	VBZ
cord-019001-ralxw4ad	147	6	untreated	untreated	JJ
cord-019001-ralxw4ad	147	7	(	(	-LRB-
cord-019001-ralxw4ad	147	8	e.g.	e.g.	RB
cord-019001-ralxw4ad	147	9	,	,	,
cord-019001-ralxw4ad	147	10	delayed	delay	VBN
cord-019001-ralxw4ad	147	11	repair	repair	NN
cord-019001-ralxw4ad	147	12	of	of	IN
cord-019001-ralxw4ad	147	13	cardiac	cardiac	JJ
cord-019001-ralxw4ad	147	14	shunt	shunt	NN
cord-019001-ralxw4ad	147	15	)	)	-RRB-
cord-019001-ralxw4ad	147	16	,	,	,
cord-019001-ralxw4ad	147	17	these	these	DT
cord-019001-ralxw4ad	147	18	structural	structural	JJ
cord-019001-ralxw4ad	147	19	changes	change	NNS
cord-019001-ralxw4ad	147	20	can	can	MD
cord-019001-ralxw4ad	147	21	progress	progress	VB
cord-019001-ralxw4ad	147	22	to	to	IN
cord-019001-ralxw4ad	147	23	the	the	DT
cord-019001-ralxw4ad	147	24	point	point	NN
cord-019001-ralxw4ad	147	25	of	of	IN
cord-019001-ralxw4ad	147	26	becoming	become	VBG
cord-019001-ralxw4ad	147	27	functionally	functionally	RB
cord-019001-ralxw4ad	147	28	"	"	``
cord-019001-ralxw4ad	147	29	fi	fi	FW
cord-019001-ralxw4ad	147	30	xed	xed	FW
cord-019001-ralxw4ad	147	31	"	"	''
cord-019001-ralxw4ad	147	32	or	or	CC
cord-019001-ralxw4ad	147	33	irreversible	irreversible	JJ
cord-019001-ralxw4ad	147	34	.	.	.
cord-019001-ralxw4ad	148	1	An	an	DT
cord-019001-ralxw4ad	148	2	important	important	JJ
cord-019001-ralxw4ad	148	3	goal	goal	NN
cord-019001-ralxw4ad	148	4	of	of	IN
cord-019001-ralxw4ad	148	5	therapy	therapy	NN
cord-019001-ralxw4ad	148	6	is	be	VBZ
cord-019001-ralxw4ad	148	7	to	to	TO
cord-019001-ralxw4ad	148	8	halt	halt	VB
cord-019001-ralxw4ad	148	9	this	this	DT
cord-019001-ralxw4ad	148	10	progression	progression	NN
cord-019001-ralxw4ad	148	11	and	and	CC
cord-019001-ralxw4ad	148	12	reverse	reverse	VB
cord-019001-ralxw4ad	148	13	the	the	DT
cord-019001-ralxw4ad	148	14	early	early	JJ
cord-019001-ralxw4ad	148	15	vascular	vascular	JJ
cord-019001-ralxw4ad	148	16	remodeling	remodeling	NN
cord-019001-ralxw4ad	148	17	if	if	IN
cord-019001-ralxw4ad	148	18	possible	possible	JJ
cord-019001-ralxw4ad	148	19	.	.	.
cord-019001-ralxw4ad	149	1	Regardless	regardless	RB
cord-019001-ralxw4ad	149	2	of	of	IN
cord-019001-ralxw4ad	149	3	the	the	DT
cord-019001-ralxw4ad	149	4	underlying	underlie	VBG
cord-019001-ralxw4ad	149	5	etiology	etiology	NN
cord-019001-ralxw4ad	149	6	,	,	,
cord-019001-ralxw4ad	149	7	the	the	DT
cord-019001-ralxw4ad	149	8	general	general	JJ
cord-019001-ralxw4ad	149	9	treatment	treatment	NN
cord-019001-ralxw4ad	149	10	approach	approach	NN
cord-019001-ralxw4ad	149	11	is	be	VBZ
cord-019001-ralxw4ad	149	12	similar	similar	JJ
cord-019001-ralxw4ad	149	13	and	and	CC
cord-019001-ralxw4ad	149	14	can	can	MD
cord-019001-ralxw4ad	149	15	be	be	VB
cord-019001-ralxw4ad	149	16	subdivided	subdivide	VBN
cord-019001-ralxw4ad	149	17	into	into	IN
cord-019001-ralxw4ad	149	18	four	four	CD
cord-019001-ralxw4ad	149	19	major	major	JJ
cord-019001-ralxw4ad	149	20	goals	goal	NNS
cord-019001-ralxw4ad	149	21	:	:	:
cord-019001-ralxw4ad	149	22	(	(	-LRB-
cord-019001-ralxw4ad	149	23	1	1	LS
cord-019001-ralxw4ad	149	24	)	)	-RRB-
cord-019001-ralxw4ad	149	25	prevent	prevent	VB
cord-019001-ralxw4ad	149	26	and	and	CC
cord-019001-ralxw4ad	149	27	acutely	acutely	RB
cord-019001-ralxw4ad	149	28	treat	treat	VB
cord-019001-ralxw4ad	149	29	active	active	JJ
cord-019001-ralxw4ad	149	30	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	149	31	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	149	32	,	,	,
cord-019001-ralxw4ad	149	33	(	(	-LRB-
cord-019001-ralxw4ad	149	34	2	2	LS
cord-019001-ralxw4ad	149	35	)	)	-RRB-
cord-019001-ralxw4ad	149	36	support	support	VBP
cord-019001-ralxw4ad	149	37	the	the	DT
cord-019001-ralxw4ad	149	38	failing	fail	VBG
cord-019001-ralxw4ad	149	39	right	right	JJ
cord-019001-ralxw4ad	149	40	ventricle	ventricle	NN
cord-019001-ralxw4ad	149	41	,	,	,
cord-019001-ralxw4ad	149	42	(	(	-LRB-
cord-019001-ralxw4ad	149	43	3	3	LS
cord-019001-ralxw4ad	149	44	)	)	-RRB-
cord-019001-ralxw4ad	149	45	treat	treat	VB
cord-019001-ralxw4ad	149	46	the	the	DT
cord-019001-ralxw4ad	149	47	underlying	underlie	VBG
cord-019001-ralxw4ad	149	48	etiology	etiology	NN
cord-019001-ralxw4ad	149	49	,	,	,
cord-019001-ralxw4ad	149	50	and	and	CC
cord-019001-ralxw4ad	149	51	(	(	-LRB-
cord-019001-ralxw4ad	149	52	4	4	LS
cord-019001-ralxw4ad	149	53	)	)	-RRB-
cord-019001-ralxw4ad	149	54	chronically	chronically	RB
cord-019001-ralxw4ad	149	55	promote	promote	VB
cord-019001-ralxw4ad	149	56	,	,	,
cord-019001-ralxw4ad	149	57	if	if	IN
cord-019001-ralxw4ad	149	58	possible	possible	JJ
cord-019001-ralxw4ad	149	59	,	,	,
cord-019001-ralxw4ad	149	60	the	the	DT
cord-019001-ralxw4ad	149	61	regression	regression	NN
cord-019001-ralxw4ad	149	62	of	of	IN
cord-019001-ralxw4ad	149	63	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	149	64	vascular	vascular	JJ
cord-019001-ralxw4ad	149	65	remodeling	remodeling	NN
cord-019001-ralxw4ad	149	66	.	.	.
cord-019001-ralxw4ad	150	1	In	in	IN
cord-019001-ralxw4ad	150	2	the	the	DT
cord-019001-ralxw4ad	150	3	intensive	intensive	JJ
cord-019001-ralxw4ad	150	4	care	care	NN
cord-019001-ralxw4ad	150	5	setting	setting	NN
cord-019001-ralxw4ad	150	6	,	,	,
cord-019001-ralxw4ad	150	7	the	the	DT
cord-019001-ralxw4ad	150	8	prevention	prevention	NN
cord-019001-ralxw4ad	150	9	and	and	CC
cord-019001-ralxw4ad	150	10	treatment	treatment	NN
cord-019001-ralxw4ad	150	11	of	of	IN
cord-019001-ralxw4ad	150	12	active	active	JJ
cord-019001-ralxw4ad	150	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	150	14	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	150	15	is	be	VBZ
cord-019001-ralxw4ad	150	16	a	a	DT
cord-019001-ralxw4ad	150	17	primary	primary	JJ
cord-019001-ralxw4ad	150	18	focus	focus	NN
cord-019001-ralxw4ad	150	19	for	for	IN
cord-019001-ralxw4ad	150	20	the	the	DT
cord-019001-ralxw4ad	150	21	care	care	NN
cord-019001-ralxw4ad	150	22	of	of	IN
cord-019001-ralxw4ad	150	23	patients	patient	NNS
cord-019001-ralxw4ad	150	24	with	with	IN
cord-019001-ralxw4ad	150	25	underlying	underlie	VBG
cord-019001-ralxw4ad	150	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	150	27	vascular	vascular	JJ
cord-019001-ralxw4ad	150	28	disease	disease	NN
cord-019001-ralxw4ad	150	29	.	.	.
cord-019001-ralxw4ad	151	1	It	-PRON-	PRP
cord-019001-ralxw4ad	151	2	is	be	VBZ
cord-019001-ralxw4ad	151	3	well	well	RB
cord-019001-ralxw4ad	151	4	appreciated	appreciate	VBN
cord-019001-ralxw4ad	151	5	that	that	IN
cord-019001-ralxw4ad	151	6	these	these	DT
cord-019001-ralxw4ad	151	7	patients	patient	NNS
cord-019001-ralxw4ad	151	8	have	have	VBP
cord-019001-ralxw4ad	151	9	augmented	augment	VBN
cord-019001-ralxw4ad	151	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	151	11	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	151	12	in	in	IN
cord-019001-ralxw4ad	151	13	response	response	NN
cord-019001-ralxw4ad	151	14	to	to	IN
cord-019001-ralxw4ad	151	15	such	such	JJ
cord-019001-ralxw4ad	151	16	stimuli	stimulus	NNS
cord-019001-ralxw4ad	151	17	as	as	IN
cord-019001-ralxw4ad	151	18	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	151	19	,	,	,
cord-019001-ralxw4ad	151	20	acidosis	acidosis	NN
cord-019001-ralxw4ad	151	21	,	,	,
cord-019001-ralxw4ad	151	22	the	the	DT
cord-019001-ralxw4ad	151	23	catecholamine	catecholamine	NN
cord-019001-ralxw4ad	151	24	-	-	HYPH
cord-019001-ralxw4ad	151	25	mediated	mediate	VBN
cord-019001-ralxw4ad	151	26	α	α	NN
cord-019001-ralxw4ad	151	27	1	1	CD
cord-019001-ralxw4ad	151	28	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	151	29	stimulation	stimulation	NN
cord-019001-ralxw4ad	151	30	associated	associate	VBN
cord-019001-ralxw4ad	151	31	with	with	IN
cord-019001-ralxw4ad	151	32	pain	pain	NN
cord-019001-ralxw4ad	151	33	and	and	CC
cord-019001-ralxw4ad	151	34	agitation	agitation	NN
cord-019001-ralxw4ad	151	35	,	,	,
cord-019001-ralxw4ad	151	36	and	and	CC
cord-019001-ralxw4ad	151	37	increases	increase	NNS
cord-019001-ralxw4ad	151	38	in	in	IN
cord-019001-ralxw4ad	151	39	intrathoracic	intrathoracic	JJ
cord-019001-ralxw4ad	151	40	pressure	pressure	NN
cord-019001-ralxw4ad	151	41	[	[	-LRB-
cord-019001-ralxw4ad	151	42	110	110	CD
cord-019001-ralxw4ad	151	43	]	]	-RRB-
cord-019001-ralxw4ad	151	44	[	[	-LRB-
cord-019001-ralxw4ad	151	45	111	111	CD
cord-019001-ralxw4ad	151	46	]	]	-RRB-
cord-019001-ralxw4ad	151	47	[	[	-LRB-
cord-019001-ralxw4ad	151	48	112	112	CD
cord-019001-ralxw4ad	151	49	]	]	-RRB-
cord-019001-ralxw4ad	151	50	.	.	.
cord-019001-ralxw4ad	152	1	In	in	IN
cord-019001-ralxw4ad	152	2	fact	fact	NN
cord-019001-ralxw4ad	152	3	,	,	,
cord-019001-ralxw4ad	152	4	acute	acute	JJ
cord-019001-ralxw4ad	152	5	increases	increase	NNS
cord-019001-ralxw4ad	152	6	in	in	IN
cord-019001-ralxw4ad	152	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	152	8	vascular	vascular	JJ
cord-019001-ralxw4ad	152	9	resistance	resistance	NN
cord-019001-ralxw4ad	152	10	can	can	MD
cord-019001-ralxw4ad	152	11	lead	lead	VB
cord-019001-ralxw4ad	152	12	to	to	IN
cord-019001-ralxw4ad	152	13	signifi	signifi	NNP
cord-019001-ralxw4ad	152	14	ca	can	MD
cord-019001-ralxw4ad	152	15	nt	not	RB
cord-019001-ralxw4ad	152	16	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	152	17	compromise	compromise	NN
cord-019001-ralxw4ad	152	18	(	(	-LRB-
cord-019001-ralxw4ad	152	19	i.e.	i.e.	FW
cord-019001-ralxw4ad	152	20	,	,	,
cord-019001-ralxw4ad	152	21	a	a	DT
cord-019001-ralxw4ad	152	22	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	152	23	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	152	24	crisis	crisis	NN
cord-019001-ralxw4ad	152	25	)	)	-RRB-
cord-019001-ralxw4ad	152	26	.	.	.
cord-019001-ralxw4ad	153	1	The	the	DT
cord-019001-ralxw4ad	153	2	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	153	3	of	of	IN
cord-019001-ralxw4ad	153	4	such	such	PDT
cord-019001-ralxw4ad	153	5	a	a	DT
cord-019001-ralxw4ad	153	6	crisis	crisis	NN
cord-019001-ralxw4ad	153	7	in	in	IN
cord-019001-ralxw4ad	153	8	outlined	outline	VBN
cord-019001-ralxw4ad	153	9	in	in	IN
cord-019001-ralxw4ad	153	10	Figure	figure	NN
cord-019001-ralxw4ad	153	11	20	20	CD
cord-019001-ralxw4ad	153	12	.3	.3	NFP
cord-019001-ralxw4ad	153	13	.	.	.
cord-019001-ralxw4ad	154	1	Following	follow	VBG
cord-019001-ralxw4ad	154	2	an	an	DT
cord-019001-ralxw4ad	154	3	acute	acute	JJ
cord-019001-ralxw4ad	154	4	increase	increase	NN
cord-019001-ralxw4ad	154	5	in	in	IN
cord-019001-ralxw4ad	154	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	154	7	arterial	arterial	JJ
cord-019001-ralxw4ad	154	8	pressure	pressure	NN
cord-019001-ralxw4ad	154	9	,	,	,
cord-019001-ralxw4ad	154	10	there	there	EX
cord-019001-ralxw4ad	154	11	is	be	VBZ
cord-019001-ralxw4ad	154	12	an	an	DT
cord-019001-ralxw4ad	154	13	acute	acute	JJ
cord-019001-ralxw4ad	154	14	increase	increase	NN
cord-019001-ralxw4ad	154	15	in	in	IN
cord-019001-ralxw4ad	154	16	right	right	JJ
cord-019001-ralxw4ad	154	17	ventricular	ventricular	JJ
cord-019001-ralxw4ad	154	18	afterload	afterload	NN
cord-019001-ralxw4ad	154	19	,	,	,
cord-019001-ralxw4ad	154	20	producing	produce	VBG
cord-019001-ralxw4ad	154	21	right	right	JJ
cord-019001-ralxw4ad	154	22	ventricular	ventricular	JJ
cord-019001-ralxw4ad	154	23	ischemia	ischemia	NN
cord-019001-ralxw4ad	154	24	and	and	CC
cord-019001-ralxw4ad	154	25	,	,	,
cord-019001-ralxw4ad	154	26	ultimately	ultimately	RB
cord-019001-ralxw4ad	154	27	,	,	,
cord-019001-ralxw4ad	154	28	failure	failure	NN
cord-019001-ralxw4ad	154	29	[	[	-LRB-
cord-019001-ralxw4ad	154	30	113	113	CD
cord-019001-ralxw4ad	154	31	,	,	,
cord-019001-ralxw4ad	154	32	114	114	CD
cord-019001-ralxw4ad	154	33	]	]	-RRB-
cord-019001-ralxw4ad	154	34	.	.	.
cord-019001-ralxw4ad	155	1	The	the	DT
cord-019001-ralxw4ad	155	2	resulting	result	VBG
cord-019001-ralxw4ad	155	3	increase	increase	NN
cord-019001-ralxw4ad	155	4	in	in	IN
cord-019001-ralxw4ad	155	5	right	right	JJ
cord-019001-ralxw4ad	155	6	ventricular	ventricular	JJ
cord-019001-ralxw4ad	155	7	end	end	NN
cord-019001-ralxw4ad	155	8	diastolic	diastolic	JJ
cord-019001-ralxw4ad	155	9	volume	volume	NN
cord-019001-ralxw4ad	155	10	shifts	shift	VBZ
cord-019001-ralxw4ad	155	11	the	the	DT
cord-019001-ralxw4ad	155	12	intraventricular	intraventricular	JJ
cord-019001-ralxw4ad	155	13	septum	septum	NN
cord-019001-ralxw4ad	155	14	to	to	IN
cord-019001-ralxw4ad	155	15	the	the	DT
cord-019001-ralxw4ad	155	16	left	left	NN
cord-019001-ralxw4ad	155	17	,	,	,
cord-019001-ralxw4ad	155	18	decreasing	decrease	VBG
cord-019001-ralxw4ad	155	19	left	left	JJ
cord-019001-ralxw4ad	155	20	ventricular	ventricular	JJ
cord-019001-ralxw4ad	155	21	volume	volume	NN
cord-019001-ralxw4ad	155	22	and	and	CC
cord-019001-ralxw4ad	155	23	cardiac	cardiac	JJ
cord-019001-ralxw4ad	155	24	output	output	NN
cord-019001-ralxw4ad	155	25	.	.	.
cord-019001-ralxw4ad	156	1	Decreased	decrease	VBN
cord-019001-ralxw4ad	156	2	cardiac	cardiac	JJ
cord-019001-ralxw4ad	156	3	output	output	NN
cord-019001-ralxw4ad	156	4	results	result	NNS
cord-019001-ralxw4ad	156	5	in	in	IN
cord-019001-ralxw4ad	156	6	decreased	decrease	VBN
cord-019001-ralxw4ad	156	7	systemic	systemic	JJ
cord-019001-ralxw4ad	156	8	perfusion	perfusion	NN
cord-019001-ralxw4ad	156	9	and	and	CC
cord-019001-ralxw4ad	156	10	metabolic	metabolic	JJ
cord-019001-ralxw4ad	156	11	acidosis	acidosis	NN
cord-019001-ralxw4ad	156	12	.	.	.
cord-019001-ralxw4ad	157	1	Increased	increase	VBN
cord-019001-ralxw4ad	157	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	157	3	vascular	vascular	JJ
cord-019001-ralxw4ad	157	4	resistance	resistance	NN
cord-019001-ralxw4ad	157	5	and	and	CC
cord-019001-ralxw4ad	157	6	right	right	JJ
cord-019001-ralxw4ad	157	7	ventricular	ventricular	JJ
cord-019001-ralxw4ad	157	8	failure	failure	NN
cord-019001-ralxw4ad	157	9	also	also	RB
cord-019001-ralxw4ad	157	10	decrease	decrease	VBP
cord-019001-ralxw4ad	157	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	157	12	blood	blood	NN
cord-019001-ralxw4ad	157	13	fl	fl	NNP
cord-019001-ralxw4ad	157	14	ow	ow	NNP
cord-019001-ralxw4ad	157	15	,	,	,
cord-019001-ralxw4ad	157	16	increasing	increase	VBG
cord-019001-ralxw4ad	157	17	dead	dead	JJ
cord-019001-ralxw4ad	157	18	space	space	NN
cord-019001-ralxw4ad	157	19	ventilation	ventilation	NN
cord-019001-ralxw4ad	157	20	.	.	.
cord-019001-ralxw4ad	158	1	Distention	Distention	NNP
cord-019001-ralxw4ad	158	2	of	of	IN
cord-019001-ralxw4ad	158	3	the	the	DT
cord-019001-ralxw4ad	158	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	158	5	arteries	artery	NNS
cord-019001-ralxw4ad	158	6	and	and	CC
cord-019001-ralxw4ad	158	7	perivascular	perivascular	JJ
cord-019001-ralxw4ad	158	8	edema	edema	NN
cord-019001-ralxw4ad	158	9	produce	produce	VBP
cord-019001-ralxw4ad	158	10	large	large	JJ
cord-019001-ralxw4ad	158	11	and	and	CC
cord-019001-ralxw4ad	158	12	small	small	JJ
cord-019001-ralxw4ad	158	13	airways	airway	NNS
cord-019001-ralxw4ad	158	14	obstruction	obstruction	NN
cord-019001-ralxw4ad	158	15	,	,	,
cord-019001-ralxw4ad	158	16	respectively	respectively	RB
cord-019001-ralxw4ad	158	17	,	,	,
cord-019001-ralxw4ad	158	18	which	which	WDT
cord-019001-ralxw4ad	158	19	impairs	impair	VBZ
cord-019001-ralxw4ad	158	20	ventilation	ventilation	NN
cord-019001-ralxw4ad	158	21	-	-	HYPH
cord-019001-ralxw4ad	158	22	perfusion	perfusion	NN
cord-019001-ralxw4ad	158	23	matching	matching	NN
cord-019001-ralxw4ad	158	24	and	and	CC
cord-019001-ralxw4ad	158	25	decreases	decrease	VBZ
cord-019001-ralxw4ad	158	26	lung	lung	NN
cord-019001-ralxw4ad	158	27	compliance	compliance	NN
cord-019001-ralxw4ad	158	28	.	.	.
cord-019001-ralxw4ad	159	1	In	in	IN
cord-019001-ralxw4ad	159	2	fact	fact	NN
cord-019001-ralxw4ad	159	3	,	,	,
cord-019001-ralxw4ad	159	4	the	the	DT
cord-019001-ralxw4ad	159	5	decrease	decrease	NN
cord-019001-ralxw4ad	159	6	in	in	IN
cord-019001-ralxw4ad	159	7	lung	lung	NN
cord-019001-ralxw4ad	159	8	compliance	compliance	NN
cord-019001-ralxw4ad	159	9	can	can	MD
cord-019001-ralxw4ad	159	10	be	be	VB
cord-019001-ralxw4ad	159	11	so	so	RB
cord-019001-ralxw4ad	159	12	dramatic	dramatic	JJ
cord-019001-ralxw4ad	159	13	that	that	IN
cord-019001-ralxw4ad	159	14	chest	chest	NN
cord-019001-ralxw4ad	159	15	wall	wall	NN
cord-019001-ralxw4ad	159	16	movement	movement	NN
cord-019001-ralxw4ad	159	17	is	be	VBZ
cord-019001-ralxw4ad	159	18	impaired	impair	VBN
cord-019001-ralxw4ad	159	19	,	,	,
cord-019001-ralxw4ad	159	20	even	even	RB
cord-019001-ralxw4ad	159	21	with	with	IN
cord-019001-ralxw4ad	159	22	manual	manual	JJ
cord-019001-ralxw4ad	159	23	ventilation	ventilation	NN
cord-019001-ralxw4ad	159	24	.	.	.
cord-019001-ralxw4ad	160	1	The	the	DT
cord-019001-ralxw4ad	160	2	ensuing	ensue	VBG
cord-019001-ralxw4ad	160	3	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	160	4	,	,	,
cord-019001-ralxw4ad	160	5	hypercapnia	hypercapnia	NN
cord-019001-ralxw4ad	160	6	,	,	,
cord-019001-ralxw4ad	160	7	and	and	CC
cord-019001-ralxw4ad	160	8	acidosis	acidosis	NN
cord-019001-ralxw4ad	160	9	(	(	-LRB-
cord-019001-ralxw4ad	160	10	metabolic	metabolic	JJ
cord-019001-ralxw4ad	160	11	and/or	and/or	CC
cord-019001-ralxw4ad	160	12	respiratory	respiratory	JJ
cord-019001-ralxw4ad	160	13	)	)	-RRB-
cord-019001-ralxw4ad	160	14	further	further	JJ
cord-019001-ralxw4ad	160	15	increase	increase	VB
cord-019001-ralxw4ad	160	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	160	17	vascular	vascular	JJ
cord-019001-ralxw4ad	160	18	resistance	resistance	NN
cord-019001-ralxw4ad	160	19	and	and	CC
cord-019001-ralxw4ad	160	20	perpetuate	perpetuate	VB
cord-019001-ralxw4ad	160	21	this	this	DT
cord-019001-ralxw4ad	160	22	cascade	cascade	NN
cord-019001-ralxw4ad	160	23	.	.	.
cord-019001-ralxw4ad	161	1	Prevention	prevention	NN
cord-019001-ralxw4ad	161	2	of	of	IN
cord-019001-ralxw4ad	161	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	161	4	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	161	5	crises	crisis	NNS
cord-019001-ralxw4ad	161	6	may	may	MD
cord-019001-ralxw4ad	161	7	be	be	VB
cord-019001-ralxw4ad	161	8	accomplished	accomplish	VBN
cord-019001-ralxw4ad	161	9	by	by	IN
cord-019001-ralxw4ad	161	10	avoiding	avoid	VBG
cord-019001-ralxw4ad	161	11	stimuli	stimulus	NNS
cord-019001-ralxw4ad	161	12	known	know	VBN
cord-019001-ralxw4ad	161	13	to	to	TO
cord-019001-ralxw4ad	161	14	increase	increase	VB
cord-019001-ralxw4ad	161	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	161	16	vascular	vascular	JJ
cord-019001-ralxw4ad	161	17	resistance	resistance	NN
cord-019001-ralxw4ad	161	18	,	,	,
cord-019001-ralxw4ad	161	19	including	include	VBG
cord-019001-ralxw4ad	161	20	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	161	21	,	,	,
cord-019001-ralxw4ad	161	22	acidosis	acidosis	NN
cord-019001-ralxw4ad	161	23	,	,	,
cord-019001-ralxw4ad	161	24	agitation	agitation	NN
cord-019001-ralxw4ad	161	25	,	,	,
cord-019001-ralxw4ad	161	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	161	27	overdistention	overdistention	NN
cord-019001-ralxw4ad	161	28	,	,	,
cord-019001-ralxw4ad	161	29	and	and	CC
cord-019001-ralxw4ad	161	30	polycythemia	polycythemia	NN
cord-019001-ralxw4ad	161	31	[	[	-LRB-
cord-019001-ralxw4ad	161	32	112	112	CD
cord-019001-ralxw4ad	161	33	]	]	-RRB-
cord-019001-ralxw4ad	161	34	.	.	.
cord-019001-ralxw4ad	162	1	Various	various	JJ
cord-019001-ralxw4ad	162	2	regimens	regimen	NNS
cord-019001-ralxw4ad	162	3	have	have	VBP
cord-019001-ralxw4ad	162	4	been	be	VBN
cord-019001-ralxw4ad	162	5	utilized	utilize	VBN
cord-019001-ralxw4ad	162	6	for	for	IN
cord-019001-ralxw4ad	162	7	this	this	DT
cord-019001-ralxw4ad	162	8	purpose	purpose	NN
cord-019001-ralxw4ad	162	9	,	,	,
cord-019001-ralxw4ad	162	10	including	include	VBG
cord-019001-ralxw4ad	162	11	the	the	DT
cord-019001-ralxw4ad	162	12	judicious	judicious	JJ
cord-019001-ralxw4ad	162	13	use	use	NN
cord-019001-ralxw4ad	162	14	of	of	IN
cord-019001-ralxw4ad	162	15	supplemental	supplemental	JJ
cord-019001-ralxw4ad	162	16	oxygen	oxygen	NN
cord-019001-ralxw4ad	162	17	,	,	,
cord-019001-ralxw4ad	162	18	analgesics	analgesic	NNS
cord-019001-ralxw4ad	162	19	,	,	,
cord-019001-ralxw4ad	162	20	sedatives	sedative	NNS
cord-019001-ralxw4ad	162	21	,	,	,
cord-019001-ralxw4ad	162	22	and	and	CC
cord-019001-ralxw4ad	162	23	muscle	muscle	NN
cord-019001-ralxw4ad	162	24	relaxants	relaxant	NNS
cord-019001-ralxw4ad	162	25	(	(	-LRB-
cord-019001-ralxw4ad	162	26	especially	especially	RB
cord-019001-ralxw4ad	162	27	before	before	IN
cord-019001-ralxw4ad	162	28	noxious	noxious	JJ
cord-019001-ralxw4ad	162	29	stimuli	stimulus	NNS
cord-019001-ralxw4ad	162	30	,	,	,
cord-019001-ralxw4ad	162	31	such	such	JJ
cord-019001-ralxw4ad	162	32	as	as	IN
cord-019001-ralxw4ad	162	33	suctioning	suctioning	NN
cord-019001-ralxw4ad	162	34	)	)	-RRB-
cord-019001-ralxw4ad	162	35	;	;	:
cord-019001-ralxw4ad	162	36	the	the	DT
cord-019001-ralxw4ad	162	37	maintenance	maintenance	NN
cord-019001-ralxw4ad	162	38	of	of	IN
cord-019001-ralxw4ad	162	39	an	an	DT
cord-019001-ralxw4ad	162	40	alkalotic	alkalotic	JJ
cord-019001-ralxw4ad	162	41	pH	ph	NN
cord-019001-ralxw4ad	162	42	with	with	IN
cord-019001-ralxw4ad	162	43	the	the	DT
cord-019001-ralxw4ad	162	44	use	use	NN
cord-019001-ralxw4ad	162	45	of	of	IN
cord-019001-ralxw4ad	162	46	controlled	control	VBN
cord-019001-ralxw4ad	162	47	ventilation	ventilation	NN
cord-019001-ralxw4ad	162	48	and	and	CC
cord-019001-ralxw4ad	162	49	buffer	buffer	NN
cord-019001-ralxw4ad	162	50	;	;	:
cord-019001-ralxw4ad	162	51	aggressive	aggressive	JJ
cord-019001-ralxw4ad	162	52	evacuation	evacuation	NN
cord-019001-ralxw4ad	162	53	of	of	IN
cord-019001-ralxw4ad	162	54	pneumothoraces	pneumothorace	NNS
cord-019001-ralxw4ad	162	55	and	and	CC
cord-019001-ralxw4ad	162	56	pleural	pleural	JJ
cord-019001-ralxw4ad	162	57	effusions	effusion	NNS
cord-019001-ralxw4ad	162	58	;	;	:
cord-019001-ralxw4ad	162	59	the	the	DT
cord-019001-ralxw4ad	162	60	utilization	utilization	NN
cord-019001-ralxw4ad	162	61	of	of	IN
cord-019001-ralxw4ad	162	62	low	low	JJ
cord-019001-ralxw4ad	162	63	lung	lung	NN
cord-019001-ralxw4ad	162	64	volume	volume	NN
cord-019001-ralxw4ad	162	65	ventilator	ventilator	NN
cord-019001-ralxw4ad	162	66	strategies	strategy	NNS
cord-019001-ralxw4ad	162	67	;	;	:
cord-019001-ralxw4ad	162	68	the	the	DT
cord-019001-ralxw4ad	162	69	minimization	minimization	NN
cord-019001-ralxw4ad	162	70	of	of	IN
cord-019001-ralxw4ad	162	71	positive	positive	JJ
cord-019001-ralxw4ad	162	72	end	end	NN
cord-019001-ralxw4ad	162	73	-	-	HYPH
cord-019001-ralxw4ad	162	74	expiratory	expiratory	NN
cord-019001-ralxw4ad	162	75	pressures	pressure	NNS
cord-019001-ralxw4ad	162	76	;	;	:
cord-019001-ralxw4ad	162	77	and	and	CC
cord-019001-ralxw4ad	162	78	the	the	DT
cord-019001-ralxw4ad	162	79	maintenance	maintenance	NN
cord-019001-ralxw4ad	162	80	of	of	IN
cord-019001-ralxw4ad	162	81	the	the	DT
cord-019001-ralxw4ad	162	82	hematocrit	hematocrit	NN
cord-019001-ralxw4ad	162	83	below	below	IN
cord-019001-ralxw4ad	162	84	55	55	CD
cord-019001-ralxw4ad	162	85	%	%	NN
cord-019001-ralxw4ad	162	86	[	[	-LRB-
cord-019001-ralxw4ad	162	87	85	85	CD
cord-019001-ralxw4ad	162	88	,	,	,
cord-019001-ralxw4ad	162	89	115	115	CD
cord-019001-ralxw4ad	162	90	]	]	-RRB-
cord-019001-ralxw4ad	162	91	.	.	.
cord-019001-ralxw4ad	163	1	In	in	IN
cord-019001-ralxw4ad	163	2	addition	addition	NN
cord-019001-ralxw4ad	163	3	,	,	,
cord-019001-ralxw4ad	163	4	data	datum	NNS
cord-019001-ralxw4ad	163	5	suggest	suggest	VBP
cord-019001-ralxw4ad	163	6	that	that	IN
cord-019001-ralxw4ad	163	7	the	the	DT
cord-019001-ralxw4ad	163	8	use	use	NN
cord-019001-ralxw4ad	163	9	of	of	IN
cord-019001-ralxw4ad	163	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	163	11	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	163	12	therapy	therapy	NN
cord-019001-ralxw4ad	163	13	may	may	MD
cord-019001-ralxw4ad	163	14	decrease	decrease	VB
cord-019001-ralxw4ad	163	15	the	the	DT
cord-019001-ralxw4ad	163	16	incidence	incidence	NN
cord-019001-ralxw4ad	163	17	of	of	IN
cord-019001-ralxw4ad	163	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	163	19	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	163	20	crises	crisis	NNS
cord-019001-ralxw4ad	163	21	[	[	-LRB-
cord-019001-ralxw4ad	163	22	116	116	CD
cord-019001-ralxw4ad	163	23	]	]	-RRB-
cord-019001-ralxw4ad	163	24	[	[	-LRB-
cord-019001-ralxw4ad	163	25	117	117	CD
cord-019001-ralxw4ad	163	26	]	]	-RRB-
cord-019001-ralxw4ad	163	27	[	[	-LRB-
cord-019001-ralxw4ad	163	28	118	118	CD
cord-019001-ralxw4ad	163	29	]	]	-RRB-
cord-019001-ralxw4ad	163	30	[	[	-LRB-
cord-019001-ralxw4ad	163	31	119	119	CD
cord-019001-ralxw4ad	163	32	]	]	-RRB-
cord-019001-ralxw4ad	163	33	[	[	-LRB-
cord-019001-ralxw4ad	163	34	120	120	CD
cord-019001-ralxw4ad	163	35	]	]	-RRB-
cord-019001-ralxw4ad	163	36	[	[	-LRB-
cord-019001-ralxw4ad	163	37	121	121	CD
cord-019001-ralxw4ad	163	38	]	]	-RRB-
cord-019001-ralxw4ad	163	39	[	[	-LRB-
cord-019001-ralxw4ad	163	40	122	122	CD
cord-019001-ralxw4ad	163	41	]	]	-RRB-
cord-019001-ralxw4ad	163	42	[	[	-LRB-
cord-019001-ralxw4ad	163	43	123	123	CD
cord-019001-ralxw4ad	163	44	]	]	-RRB-
cord-019001-ralxw4ad	163	45	[	[	-LRB-
cord-019001-ralxw4ad	163	46	124	124	CD
cord-019001-ralxw4ad	163	47	]	]	-RRB-
cord-019001-ralxw4ad	163	48	[	[	-LRB-
cord-019001-ralxw4ad	163	49	125	125	CD
cord-019001-ralxw4ad	163	50	]	]	-RRB-
cord-019001-ralxw4ad	163	51	[	[	-LRB-
cord-019001-ralxw4ad	163	52	126	126	CD
cord-019001-ralxw4ad	163	53	]	]	-RRB-
cord-019001-ralxw4ad	163	54	[	[	-LRB-
cord-019001-ralxw4ad	163	55	127	127	CD
cord-019001-ralxw4ad	163	56	]	]	-RRB-
cord-019001-ralxw4ad	163	57	[	[	-LRB-
cord-019001-ralxw4ad	163	58	128	128	CD
cord-019001-ralxw4ad	163	59	]	]	-RRB-
cord-019001-ralxw4ad	163	60	.	.	.
cord-019001-ralxw4ad	164	1	Treatment	treatment	NN
cord-019001-ralxw4ad	164	2	of	of	IN
cord-019001-ralxw4ad	164	3	active	active	JJ
cord-019001-ralxw4ad	164	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	164	5	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	164	6	is	be	VBZ
cord-019001-ralxw4ad	164	7	accomplished	accomplish	VBN
cord-019001-ralxw4ad	164	8	with	with	IN
cord-019001-ralxw4ad	164	9	the	the	DT
cord-019001-ralxw4ad	164	10	use	use	NN
cord-019001-ralxw4ad	164	11	of	of	IN
cord-019001-ralxw4ad	164	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	164	13	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	164	14	therapy	therapy	NN
cord-019001-ralxw4ad	164	15	.	.	.
cord-019001-ralxw4ad	165	1	The	the	DT
cord-019001-ralxw4ad	165	2	mainstay	mainstay	NN
cord-019001-ralxw4ad	165	3	of	of	IN
cord-019001-ralxw4ad	165	4	acute	acute	JJ
cord-019001-ralxw4ad	165	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	165	6	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	165	7	therapy	therapy	NN
cord-019001-ralxw4ad	165	8	remains	remain	VBZ
cord-019001-ralxw4ad	165	9	supplemental	supplemental	JJ
cord-019001-ralxw4ad	165	10	oxygen	oxygen	NN
cord-019001-ralxw4ad	165	11	and	and	CC
cord-019001-ralxw4ad	165	12	moderate	moderate	JJ
cord-019001-ralxw4ad	165	13	alkalosis	alkalosis	NN
cord-019001-ralxw4ad	165	14	,	,	,
cord-019001-ralxw4ad	165	15	as	as	IN
cord-019001-ralxw4ad	165	16	these	these	DT
cord-019001-ralxw4ad	165	17	therapies	therapy	NNS
cord-019001-ralxw4ad	165	18	have	have	VBP
cord-019001-ralxw4ad	165	19	minimal	minimal	JJ
cord-019001-ralxw4ad	165	20	effects	effect	NNS
cord-019001-ralxw4ad	165	21	on	on	IN
cord-019001-ralxw4ad	165	22	the	the	DT
cord-019001-ralxw4ad	165	23	systemic	systemic	JJ
cord-019001-ralxw4ad	165	24	vasculature	vasculature	NN
cord-019001-ralxw4ad	165	25	.	.	.
cord-019001-ralxw4ad	166	1	Interestingly	interestingly	RB
cord-019001-ralxw4ad	166	2	,	,	,
cord-019001-ralxw4ad	166	3	the	the	DT
cord-019001-ralxw4ad	166	4	dose	dose	NN
cord-019001-ralxw4ad	166	5	-	-	HYPH
cord-019001-ralxw4ad	166	6	dependent	dependent	JJ
cord-019001-ralxw4ad	166	7	response	response	NN
cord-019001-ralxw4ad	166	8	of	of	IN
cord-019001-ralxw4ad	166	9	the	the	DT
cord-019001-ralxw4ad	166	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	166	11	vasculature	vasculature	NN
cord-019001-ralxw4ad	166	12	to	to	IN
cord-019001-ralxw4ad	166	13	these	these	DT
cord-019001-ralxw4ad	166	14	agents	agent	NNS
cord-019001-ralxw4ad	166	15	has	have	VBZ
cord-019001-ralxw4ad	166	16	not	not	RB
cord-019001-ralxw4ad	166	17	been	be	VBN
cord-019001-ralxw4ad	166	18	well	well	RB
cord-019001-ralxw4ad	166	19	established	establish	VBN
cord-019001-ralxw4ad	166	20	.	.	.
cord-019001-ralxw4ad	167	1	Studies	study	NNS
cord-019001-ralxw4ad	167	2	in	in	IN
cord-019001-ralxw4ad	167	3	newborn	newborn	JJ
cord-019001-ralxw4ad	167	4	lambs	lamb	NNS
cord-019001-ralxw4ad	167	5	demonstrate	demonstrate	VBP
cord-019001-ralxw4ad	167	6	dosedependent	dosedependent	NN
cord-019001-ralxw4ad	167	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	167	8	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	167	9	in	in	IN
cord-019001-ralxw4ad	167	10	response	response	NN
cord-019001-ralxw4ad	167	11	to	to	IN
cord-019001-ralxw4ad	167	12	increasing	increase	VBG
cord-019001-ralxw4ad	167	13	pH	pH	NNP
cord-019001-ralxw4ad	167	14	from	from	IN
cord-019001-ralxw4ad	167	15	7.30	7.30	CD
cord-019001-ralxw4ad	167	16	to	to	IN
cord-019001-ralxw4ad	167	17	7.60	7.60	CD
cord-019001-ralxw4ad	167	18	,	,	,
cord-019001-ralxw4ad	167	19	and	and	CC
cord-019001-ralxw4ad	167	20	a	a	DT
cord-019001-ralxw4ad	167	21	dose	dose	NN
cord-019001-ralxw4ad	167	22	-	-	HYPH
cord-019001-ralxw4ad	167	23	dependent	dependent	JJ
cord-019001-ralxw4ad	167	24	response	response	NN
cord-019001-ralxw4ad	167	25	to	to	IN
cord-019001-ralxw4ad	167	26	increasing	increase	VBG
cord-019001-ralxw4ad	167	27	inspired	inspire	VBN
cord-019001-ralxw4ad	167	28	oxygen	oxygen	NN
cord-019001-ralxw4ad	167	29	concentrations	concentration	NNS
cord-019001-ralxw4ad	167	30	from	from	IN
cord-019001-ralxw4ad	167	31	0.21	0.21	CD
cord-019001-ralxw4ad	167	32	to	to	IN
cord-019001-ralxw4ad	167	33	0.5	0.5	CD
cord-019001-ralxw4ad	167	34	,	,	,
cord-019001-ralxw4ad	167	35	with	with	IN
cord-019001-ralxw4ad	167	36	minimal	minimal	JJ
cord-019001-ralxw4ad	167	37	effects	effect	NNS
cord-019001-ralxw4ad	167	38	at	at	IN
cord-019001-ralxw4ad	167	39	higher	high	JJR
cord-019001-ralxw4ad	167	40	concentrations	concentration	NNS
cord-019001-ralxw4ad	167	41	[	[	-LRB-
cord-019001-ralxw4ad	167	42	129	129	CD
cord-019001-ralxw4ad	167	43	]	]	-RRB-
cord-019001-ralxw4ad	167	44	.	.	.
cord-019001-ralxw4ad	168	1	Several	several	JJ
cord-019001-ralxw4ad	168	2	intravenous	intravenous	JJ
cord-019001-ralxw4ad	168	3	agents	agent	NNS
cord-019001-ralxw4ad	168	4	have	have	VBP
cord-019001-ralxw4ad	168	5	been	be	VBN
cord-019001-ralxw4ad	168	6	utilized	utilize	VBN
cord-019001-ralxw4ad	168	7	to	to	TO
cord-019001-ralxw4ad	168	8	promote	promote	VB
cord-019001-ralxw4ad	168	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	168	10	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	168	11	,	,	,
cord-019001-ralxw4ad	168	12	including	include	VBG
cord-019001-ralxw4ad	168	13	tolazoline	tolazoline	NN
cord-019001-ralxw4ad	168	14	,	,	,
cord-019001-ralxw4ad	168	15	sodium	sodium	NN
cord-019001-ralxw4ad	168	16	nitroprusside	nitroprusside	RB
cord-019001-ralxw4ad	168	17	,	,	,
cord-019001-ralxw4ad	168	18	nitroglycerin	nitroglycerin	NN
cord-019001-ralxw4ad	168	19	,	,	,
cord-019001-ralxw4ad	168	20	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	168	21	,	,	,
cord-019001-ralxw4ad	168	22	prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	168	23	E	e	NN
cord-019001-ralxw4ad	168	24	1	1	CD
cord-019001-ralxw4ad	168	25	,	,	,
cord-019001-ralxw4ad	168	26	nifedipine	nifedipine	NN
cord-019001-ralxw4ad	168	27	,	,	,
cord-019001-ralxw4ad	168	28	and	and	CC
cord-019001-ralxw4ad	168	29	α	α	NN
cord-019001-ralxw4ad	168	30	-	-	HYPH
cord-019001-ralxw4ad	168	31	adrenergic	adrenergic	JJ
cord-019001-ralxw4ad	168	32	antagonists	antagonist	NNS
cord-019001-ralxw4ad	168	33	,	,	,
cord-019001-ralxw4ad	168	34	such	such	JJ
cord-019001-ralxw4ad	168	35	as	as	IN
cord-019001-ralxw4ad	168	36	phenoxybenzamine	phenoxybenzamine	NNP
cord-019001-ralxw4ad	168	37	[	[	-LRB-
cord-019001-ralxw4ad	168	38	130	130	CD
cord-019001-ralxw4ad	168	39	]	]	-RRB-
cord-019001-ralxw4ad	169	1	[	[	-LRB-
cord-019001-ralxw4ad	169	2	131	131	CD
cord-019001-ralxw4ad	169	3	]	]	-RRB-
cord-019001-ralxw4ad	169	4	[	[	-LRB-
cord-019001-ralxw4ad	169	5	132	132	CD
cord-019001-ralxw4ad	169	6	]	]	-RRB-
cord-019001-ralxw4ad	169	7	[	[	-LRB-
cord-019001-ralxw4ad	169	8	133	133	CD
cord-019001-ralxw4ad	169	9	]	]	-RRB-
cord-019001-ralxw4ad	169	10	[	[	-LRB-
cord-019001-ralxw4ad	169	11	134	134	CD
cord-019001-ralxw4ad	169	12	]	]	-RRB-
cord-019001-ralxw4ad	169	13	[	[	-LRB-
cord-019001-ralxw4ad	169	14	135	135	CD
cord-019001-ralxw4ad	169	15	]	]	-RRB-
cord-019001-ralxw4ad	169	16	[	[	-LRB-
cord-019001-ralxw4ad	169	17	136	136	CD
cord-019001-ralxw4ad	169	18	]	]	-RRB-
cord-019001-ralxw4ad	169	19	[	[	-LRB-
cord-019001-ralxw4ad	169	20	137	137	CD
cord-019001-ralxw4ad	169	21	]	]	-RRB-
cord-019001-ralxw4ad	169	22	.	.	.
cord-019001-ralxw4ad	170	1	The	the	DT
cord-019001-ralxw4ad	170	2	effi	effi	JJ
cord-019001-ralxw4ad	170	3	cacies	cacie	NNS
cord-019001-ralxw4ad	170	4	of	of	IN
cord-019001-ralxw4ad	170	5	these	these	DT
cord-019001-ralxw4ad	170	6	agents	agent	NNS
cord-019001-ralxw4ad	170	7	are	be	VBP
cord-019001-ralxw4ad	170	8	variable	variable	JJ
cord-019001-ralxw4ad	170	9	,	,	,
cord-019001-ralxw4ad	170	10	at	at	IN
cord-019001-ralxw4ad	170	11	least	least	JJS
cord-019001-ralxw4ad	170	12	in	in	IN
cord-019001-ralxw4ad	170	13	part	part	NN
cord-019001-ralxw4ad	170	14	because	because	IN
cord-019001-ralxw4ad	170	15	of	of	IN
cord-019001-ralxw4ad	170	16	their	-PRON-	PRP$
cord-019001-ralxw4ad	170	17	effects	effect	NNS
cord-019001-ralxw4ad	170	18	on	on	IN
cord-019001-ralxw4ad	170	19	the	the	DT
cord-019001-ralxw4ad	170	20	systemic	systemic	JJ
cord-019001-ralxw4ad	170	21	vasculature	vasculature	NN
cord-019001-ralxw4ad	170	22	.	.	.
cord-019001-ralxw4ad	171	1	Systemic	systemic	JJ
cord-019001-ralxw4ad	171	2	afterload	afterload	NN
cord-019001-ralxw4ad	171	3	reduction	reduction	NN
cord-019001-ralxw4ad	171	4	can	can	MD
cord-019001-ralxw4ad	171	5	be	be	VB
cord-019001-ralxw4ad	171	6	advantageous	advantageous	JJ
cord-019001-ralxw4ad	171	7	in	in	IN
cord-019001-ralxw4ad	171	8	the	the	DT
cord-019001-ralxw4ad	171	9	setting	setting	NN
cord-019001-ralxw4ad	171	10	of	of	IN
cord-019001-ralxw4ad	171	11	left	left	JJ
cord-019001-ralxw4ad	171	12	ventricular	ventricular	JJ
cord-019001-ralxw4ad	171	13	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	171	14	;	;	:
cord-019001-ralxw4ad	171	15	however	however	RB
cord-019001-ralxw4ad	171	16	,	,	,
cord-019001-ralxw4ad	171	17	signifi	signifi	NNP
cord-019001-ralxw4ad	171	18	ca	can	MD
cord-019001-ralxw4ad	171	19	nt	not	RB
cord-019001-ralxw4ad	171	20	reductions	reduction	NNS
cord-019001-ralxw4ad	171	21	in	in	IN
cord-019001-ralxw4ad	171	22	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	171	23	arterial	arterial	JJ
cord-019001-ralxw4ad	171	24	pressure	pressure	NN
cord-019001-ralxw4ad	171	25	without	without	IN
cord-019001-ralxw4ad	171	26	unacceptable	unacceptable	JJ
cord-019001-ralxw4ad	171	27	systemic	systemic	JJ
cord-019001-ralxw4ad	171	28	hypotension	hypotension	NN
cord-019001-ralxw4ad	171	29	are	be	VBP
cord-019001-ralxw4ad	171	30	often	often	RB
cord-019001-ralxw4ad	171	31	not	not	RB
cord-019001-ralxw4ad	171	32	possible	possible	JJ
cord-019001-ralxw4ad	171	33	[	[	-LRB-
cord-019001-ralxw4ad	171	34	138	138	CD
cord-019001-ralxw4ad	171	35	]	]	-RRB-
cord-019001-ralxw4ad	172	1	[	[	-LRB-
cord-019001-ralxw4ad	172	2	139	139	CD
cord-019001-ralxw4ad	172	3	]	]	-RRB-
cord-019001-ralxw4ad	172	4	[	[	-LRB-
cord-019001-ralxw4ad	172	5	140	140	CD
cord-019001-ralxw4ad	172	6	]	]	-RRB-
cord-019001-ralxw4ad	172	7	.	.	.
cord-019001-ralxw4ad	173	1	In	in	IN
cord-019001-ralxw4ad	173	2	addition	addition	NN
cord-019001-ralxw4ad	173	3	,	,	,
cord-019001-ralxw4ad	173	4	intravenous	intravenous	JJ
cord-019001-ralxw4ad	173	5	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	173	6	can	can	MD
cord-019001-ralxw4ad	173	7	override	override	VB
cord-019001-ralxw4ad	173	8	intrinsic	intrinsic	JJ
cord-019001-ralxw4ad	173	9	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	173	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	173	11	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	173	12	,	,	,
cord-019001-ralxw4ad	173	13	resulting	result	VBG
cord-019001-ralxw4ad	173	14	in	in	IN
cord-019001-ralxw4ad	173	15	an	an	DT
cord-019001-ralxw4ad	173	16	increase	increase	NN
cord-019001-ralxw4ad	173	17	in	in	IN
cord-019001-ralxw4ad	173	18	dead	dead	JJ
cord-019001-ralxw4ad	173	19	space	space	NN
cord-019001-ralxw4ad	173	20	ventilation	ventilation	NN
cord-019001-ralxw4ad	173	21	,	,	,
cord-019001-ralxw4ad	173	22	which	which	WDT
cord-019001-ralxw4ad	173	23	may	may	MD
cord-019001-ralxw4ad	173	24	not	not	RB
cord-019001-ralxw4ad	173	25	be	be	VB
cord-019001-ralxw4ad	173	26	tolerated	tolerate	VBN
cord-019001-ralxw4ad	173	27	in	in	IN
cord-019001-ralxw4ad	173	28	some	some	DT
cord-019001-ralxw4ad	173	29	critically	critically	RB
cord-019001-ralxw4ad	173	30	ill	ill	JJ
cord-019001-ralxw4ad	173	31	patients	patient	NNS
cord-019001-ralxw4ad	173	32	[	[	-LRB-
cord-019001-ralxw4ad	173	33	141	141	CD
cord-019001-ralxw4ad	173	34	]	]	-RRB-
cord-019001-ralxw4ad	173	35	[	[	-LRB-
cord-019001-ralxw4ad	173	36	142	142	CD
cord-019001-ralxw4ad	173	37	]	]	-RRB-
cord-019001-ralxw4ad	173	38	[	[	-LRB-
cord-019001-ralxw4ad	173	39	143	143	CD
cord-019001-ralxw4ad	173	40	]	]	-RRB-
cord-019001-ralxw4ad	173	41	[	[	-LRB-
cord-019001-ralxw4ad	173	42	144	144	CD
cord-019001-ralxw4ad	173	43	]	]	-RRB-
cord-019001-ralxw4ad	173	44	[	[	-LRB-
cord-019001-ralxw4ad	173	45	145	145	CD
cord-019001-ralxw4ad	173	46	]	]	-RRB-
cord-019001-ralxw4ad	173	47	.	.	.
cord-019001-ralxw4ad	174	1	More	More	JJR
cord-019001-ralxw4ad	174	2	recent	recent	JJ
cord-019001-ralxw4ad	174	3	treatment	treatment	NN
cord-019001-ralxw4ad	174	4	modalities	modality	NNS
cord-019001-ralxw4ad	174	5	,	,	,
cord-019001-ralxw4ad	174	6	most	most	RBS
cord-019001-ralxw4ad	174	7	notably	notably	RB
cord-019001-ralxw4ad	174	8	inhaled	inhale	VBN
cord-019001-ralxw4ad	174	9	NO	no	UH
cord-019001-ralxw4ad	174	10	,	,	,
cord-019001-ralxw4ad	174	11	deliver	deliver	VB
cord-019001-ralxw4ad	174	12	short	short	RB
cord-019001-ralxw4ad	174	13	-	-	HYPH
cord-019001-ralxw4ad	174	14	acting	act	VBG
cord-019001-ralxw4ad	174	15	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	174	16	to	to	IN
cord-019001-ralxw4ad	174	17	the	the	DT
cord-019001-ralxw4ad	174	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	174	19	vasculature	vasculature	NN
cord-019001-ralxw4ad	174	20	via	via	IN
cord-019001-ralxw4ad	174	21	an	an	DT
cord-019001-ralxw4ad	174	22	inhalational	inhalational	JJ
cord-019001-ralxw4ad	174	23	route	route	NN
cord-019001-ralxw4ad	174	24	[	[	-LRB-
cord-019001-ralxw4ad	174	25	116	116	CD
cord-019001-ralxw4ad	174	26	]	]	-RRB-
cord-019001-ralxw4ad	174	27	[	[	-LRB-
cord-019001-ralxw4ad	174	28	117	117	CD
cord-019001-ralxw4ad	174	29	]	]	-RRB-
cord-019001-ralxw4ad	174	30	[	[	-LRB-
cord-019001-ralxw4ad	174	31	118	118	CD
cord-019001-ralxw4ad	174	32	]	]	-RRB-
cord-019001-ralxw4ad	174	33	[	[	-LRB-
cord-019001-ralxw4ad	174	34	119	119	CD
cord-019001-ralxw4ad	174	35	]	]	-RRB-
cord-019001-ralxw4ad	174	36	[	[	-LRB-
cord-019001-ralxw4ad	174	37	120	120	CD
cord-019001-ralxw4ad	174	38	]	]	-RRB-
cord-019001-ralxw4ad	174	39	[	[	-LRB-
cord-019001-ralxw4ad	174	40	121	121	CD
cord-019001-ralxw4ad	174	41	]	]	-RRB-
cord-019001-ralxw4ad	174	42	[	[	-LRB-
cord-019001-ralxw4ad	174	43	122	122	CD
cord-019001-ralxw4ad	174	44	]	]	-RRB-
cord-019001-ralxw4ad	174	45	[	[	-LRB-
cord-019001-ralxw4ad	174	46	123	123	CD
cord-019001-ralxw4ad	174	47	]	]	-RRB-
cord-019001-ralxw4ad	174	48	[	[	-LRB-
cord-019001-ralxw4ad	174	49	124	124	CD
cord-019001-ralxw4ad	174	50	]	]	-RRB-
cord-019001-ralxw4ad	174	51	[	[	-LRB-
cord-019001-ralxw4ad	174	52	125	125	CD
cord-019001-ralxw4ad	174	53	]	]	-RRB-
cord-019001-ralxw4ad	174	54	[	[	-LRB-
cord-019001-ralxw4ad	174	55	126	126	CD
cord-019001-ralxw4ad	174	56	]	]	-RRB-
cord-019001-ralxw4ad	174	57	[	[	-LRB-
cord-019001-ralxw4ad	174	58	127	127	CD
cord-019001-ralxw4ad	174	59	]	]	-RRB-
cord-019001-ralxw4ad	174	60	[	[	-LRB-
cord-019001-ralxw4ad	174	61	128	128	CD
cord-019001-ralxw4ad	174	62	]	]	-RRB-
cord-019001-ralxw4ad	174	63	.	.	.
cord-019001-ralxw4ad	175	1	When	when	WRB
cord-019001-ralxw4ad	175	2	administered	administer	VBN
cord-019001-ralxw4ad	175	3	to	to	IN
cord-019001-ralxw4ad	175	4	the	the	DT
cord-019001-ralxw4ad	175	5	lung	lung	NN
cord-019001-ralxw4ad	175	6	in	in	IN
cord-019001-ralxw4ad	175	7	its	-PRON-	PRP$
cord-019001-ralxw4ad	175	8	natural	natural	JJ
cord-019001-ralxw4ad	175	9	gaseous	gaseous	JJ
cord-019001-ralxw4ad	175	10	form	form	NN
cord-019001-ralxw4ad	175	11	,	,	,
cord-019001-ralxw4ad	175	12	NO	NO	NNP
cord-019001-ralxw4ad	175	13	diffuses	diffuse	VBZ
cord-019001-ralxw4ad	175	14	through	through	IN
cord-019001-ralxw4ad	175	15	the	the	DT
cord-019001-ralxw4ad	175	16	alveolar	alveolar	JJ
cord-019001-ralxw4ad	175	17	wall	wall	NN
cord-019001-ralxw4ad	175	18	to	to	TO
cord-019001-ralxw4ad	175	19	reach	reach	VB
cord-019001-ralxw4ad	175	20	small	small	JJ
cord-019001-ralxw4ad	175	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	175	22	arteries	artery	NNS
cord-019001-ralxw4ad	175	23	.	.	.
cord-019001-ralxw4ad	176	1	It	-PRON-	PRP
cord-019001-ralxw4ad	176	2	then	then	RB
cord-019001-ralxw4ad	176	3	enters	enter	VBZ
cord-019001-ralxw4ad	176	4	vascular	vascular	JJ
cord-019001-ralxw4ad	176	5	smooth	smooth	JJ
cord-019001-ralxw4ad	176	6	muscle	muscle	NN
cord-019001-ralxw4ad	176	7	cells	cell	NNS
cord-019001-ralxw4ad	176	8	,	,	,
cord-019001-ralxw4ad	176	9	initiating	initiate	VBG
cord-019001-ralxw4ad	176	10	a	a	DT
cord-019001-ralxw4ad	176	11	cascade	cascade	NN
cord-019001-ralxw4ad	176	12	that	that	WDT
cord-019001-ralxw4ad	176	13	results	result	VBZ
cord-019001-ralxw4ad	176	14	in	in	IN
cord-019001-ralxw4ad	176	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	176	16	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	176	17	via	via	IN
cord-019001-ralxw4ad	176	18	increases	increase	NNS
cord-019001-ralxw4ad	176	19	in	in	IN
cord-019001-ralxw4ad	176	20	cGMP	cGMP	NNP
cord-019001-ralxw4ad	176	21	.	.	.
cord-019001-ralxw4ad	177	1	After	after	IN
cord-019001-ralxw4ad	177	2	entering	enter	VBG
cord-019001-ralxw4ad	177	3	the	the	DT
cord-019001-ralxw4ad	177	4	blood	blood	NN
cord-019001-ralxw4ad	177	5	vessel	vessel	NN
cord-019001-ralxw4ad	177	6	lumen	lumen	NN
cord-019001-ralxw4ad	177	7	,	,	,
cord-019001-ralxw4ad	177	8	NO	no	UH
cord-019001-ralxw4ad	177	9	is	be	VBZ
cord-019001-ralxw4ad	177	10	rapidly	rapidly	RB
cord-019001-ralxw4ad	177	11	inactivated	inactivate	VBN
cord-019001-ralxw4ad	177	12	by	by	IN
cord-019001-ralxw4ad	177	13	hemoglobin	hemoglobin	NN
cord-019001-ralxw4ad	177	14	,	,	,
cord-019001-ralxw4ad	177	15	which	which	WDT
cord-019001-ralxw4ad	177	16	confi	confi	NNP
cord-019001-ralxw4ad	177	17	nes	nes	NNP
cord-019001-ralxw4ad	177	18	its	-PRON-	PRP$
cord-019001-ralxw4ad	177	19	effects	effect	NNS
cord-019001-ralxw4ad	177	20	to	to	IN
cord-019001-ralxw4ad	177	21	the	the	DT
cord-019001-ralxw4ad	177	22	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	177	23	vasculature	vasculature	NN
cord-019001-ralxw4ad	177	24	.	.	.
cord-019001-ralxw4ad	178	1	Because	because	IN
cord-019001-ralxw4ad	178	2	of	of	IN
cord-019001-ralxw4ad	178	3	these	these	DT
cord-019001-ralxw4ad	178	4	properties	property	NNS
cord-019001-ralxw4ad	178	5	,	,	,
cord-019001-ralxw4ad	178	6	inhaled	inhale	VBN
cord-019001-ralxw4ad	178	7	NO	no	RB
cord-019001-ralxw4ad	178	8	has	have	VBZ
cord-019001-ralxw4ad	178	9	several	several	JJ
cord-019001-ralxw4ad	178	10	advantages	advantage	NNS
cord-019001-ralxw4ad	178	11	over	over	IN
cord-019001-ralxw4ad	178	12	other	other	JJ
cord-019001-ralxw4ad	178	13	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	178	14	,	,	,
cord-019001-ralxw4ad	178	15	including	include	VBG
cord-019001-ralxw4ad	178	16	(	(	-LRB-
cord-019001-ralxw4ad	178	17	1	1	CD
cord-019001-ralxw4ad	178	18	)	)	-RRB-
cord-019001-ralxw4ad	178	19	selective	selective	JJ
cord-019001-ralxw4ad	178	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	178	21	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	178	22	caused	cause	VBN
cord-019001-ralxw4ad	178	23	by	by	IN
cord-019001-ralxw4ad	178	24	rapid	rapid	JJ
cord-019001-ralxw4ad	178	25	inactivation	inactivation	NN
cord-019001-ralxw4ad	178	26	by	by	IN
cord-019001-ralxw4ad	178	27	hemoglobin	hemoglobin	NN
cord-019001-ralxw4ad	178	28	,	,	,
cord-019001-ralxw4ad	178	29	(	(	-LRB-
cord-019001-ralxw4ad	178	30	2	2	LS
cord-019001-ralxw4ad	178	31	)	)	-RRB-
cord-019001-ralxw4ad	178	32	rapid	rapid	JJ
cord-019001-ralxw4ad	178	33	onset	onset	NN
cord-019001-ralxw4ad	178	34	and	and	CC
cord-019001-ralxw4ad	178	35	elimination	elimination	NN
cord-019001-ralxw4ad	178	36	,	,	,
cord-019001-ralxw4ad	178	37	and	and	CC
cord-019001-ralxw4ad	178	38	(	(	-LRB-
cord-019001-ralxw4ad	178	39	3	3	LS
cord-019001-ralxw4ad	178	40	)	)	-RRB-
cord-019001-ralxw4ad	178	41	an	an	DT
cord-019001-ralxw4ad	178	42	improvement	improvement	NN
cord-019001-ralxw4ad	178	43	in	in	IN
cord-019001-ralxw4ad	178	44	ventilation	ventilation	NN
cord-019001-ralxw4ad	178	45	-	-	HYPH
cord-019001-ralxw4ad	178	46	perfusion	perfusion	NN
cord-019001-ralxw4ad	178	47	matching	matching	NN
cord-019001-ralxw4ad	178	48	because	because	IN
cord-019001-ralxw4ad	178	49	of	of	IN
cord-019001-ralxw4ad	178	50	the	the	DT
cord-019001-ralxw4ad	178	51	limitation	limitation	NN
cord-019001-ralxw4ad	178	52	of	of	IN
cord-019001-ralxw4ad	178	53	delivery	delivery	NN
cord-019001-ralxw4ad	178	54	to	to	IN
cord-019001-ralxw4ad	178	55	well	well	RB
cord-019001-ralxw4ad	178	56	-	-	HYPH
cord-019001-ralxw4ad	178	57	ventilated	ventilate	VBN
cord-019001-ralxw4ad	178	58	lung	lung	NN
cord-019001-ralxw4ad	178	59	regions	region	NNS
cord-019001-ralxw4ad	178	60	.	.	.
cord-019001-ralxw4ad	179	1	Accordingly	accordingly	RB
cord-019001-ralxw4ad	179	2	,	,	,
cord-019001-ralxw4ad	179	3	inhaled	inhale	VBN
cord-019001-ralxw4ad	179	4	NO	no	DT
cord-019001-ralxw4ad	179	5	has	have	VBZ
cord-019001-ralxw4ad	179	6	become	become	VBN
cord-019001-ralxw4ad	179	7	a	a	DT
cord-019001-ralxw4ad	179	8	mainstay	mainstay	NN
cord-019001-ralxw4ad	179	9	of	of	IN
cord-019001-ralxw4ad	179	10	treatment	treatment	NN
cord-019001-ralxw4ad	179	11	for	for	IN
cord-019001-ralxw4ad	179	12	acute	acute	JJ
cord-019001-ralxw4ad	179	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	179	14	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	179	15	disorders	disorder	NNS
cord-019001-ralxw4ad	179	16	and	and	CC
cord-019001-ralxw4ad	179	17	the	the	DT
cord-019001-ralxw4ad	179	18	assessment	assessment	NN
cord-019001-ralxw4ad	179	19	of	of	IN
cord-019001-ralxw4ad	179	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	179	21	vascular	vascular	JJ
cord-019001-ralxw4ad	179	22	reactivity	reactivity	NN
cord-019001-ralxw4ad	179	23	.	.	.
cord-019001-ralxw4ad	180	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	180	2	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	180	3	has	have	VBZ
cord-019001-ralxw4ad	180	4	similar	similar	JJ
cord-019001-ralxw4ad	180	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	180	6	selectivity	selectivity	NN
cord-019001-ralxw4ad	180	7	,	,	,
cord-019001-ralxw4ad	180	8	secondary	secondary	JJ
cord-019001-ralxw4ad	180	9	to	to	IN
cord-019001-ralxw4ad	180	10	rapid	rapid	JJ
cord-019001-ralxw4ad	180	11	inactivation	inactivation	NN
cord-019001-ralxw4ad	180	12	by	by	IN
cord-019001-ralxw4ad	180	13	hemoglobin	hemoglobin	NN
cord-019001-ralxw4ad	180	14	.	.	.
cord-019001-ralxw4ad	181	1	Its	-PRON-	PRP$
cord-019001-ralxw4ad	181	2	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	181	3	effects	effect	NNS
cord-019001-ralxw4ad	181	4	are	be	VBP
cord-019001-ralxw4ad	181	5	secondary	secondary	JJ
cord-019001-ralxw4ad	181	6	to	to	IN
cord-019001-ralxw4ad	181	7	increasing	increase	VBG
cord-019001-ralxw4ad	181	8	cAMP	camp	NN
cord-019001-ralxw4ad	181	9	concentrations	concentration	NNS
cord-019001-ralxw4ad	181	10	.	.	.
cord-019001-ralxw4ad	182	1	Currently	currently	RB
cord-019001-ralxw4ad	182	2	,	,	,
cord-019001-ralxw4ad	182	3	studies	study	NNS
cord-019001-ralxw4ad	182	4	on	on	IN
cord-019001-ralxw4ad	182	5	the	the	DT
cord-019001-ralxw4ad	182	6	use	use	NN
cord-019001-ralxw4ad	182	7	of	of	IN
cord-019001-ralxw4ad	182	8	inhaled	inhale	VBN
cord-019001-ralxw4ad	182	9	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	182	10	for	for	IN
cord-019001-ralxw4ad	182	11	pediatric	pediatric	JJ
cord-019001-ralxw4ad	182	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	182	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	182	14	are	be	VBP
cord-019001-ralxw4ad	182	15	sparse	sparse	JJ
cord-019001-ralxw4ad	182	16	,	,	,
cord-019001-ralxw4ad	182	17	and	and	CC
cord-019001-ralxw4ad	182	18	comparison	comparison	NN
cord-019001-ralxw4ad	182	19	studies	study	NNS
cord-019001-ralxw4ad	182	20	between	between	IN
cord-019001-ralxw4ad	182	21	inhaled	inhale	VBN
cord-019001-ralxw4ad	182	22	NO	NO	NNP
cord-019001-ralxw4ad	182	23	and	and	CC
cord-019001-ralxw4ad	182	24	inhaled	inhale	VBN
cord-019001-ralxw4ad	182	25	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	182	26	are	be	VBP
cord-019001-ralxw4ad	182	27	lacking	lack	VBG
cord-019001-ralxw4ad	182	28	[	[	-LRB-
cord-019001-ralxw4ad	182	29	146	146	CD
cord-019001-ralxw4ad	182	30	]	]	-RRB-
cord-019001-ralxw4ad	182	31	[	[	-LRB-
cord-019001-ralxw4ad	182	32	147	147	CD
cord-019001-ralxw4ad	182	33	]	]	-RRB-
cord-019001-ralxw4ad	182	34	[	[	-LRB-
cord-019001-ralxw4ad	182	35	148	148	CD
cord-019001-ralxw4ad	182	36	]	]	-RRB-
cord-019001-ralxw4ad	182	37	[	[	-LRB-
cord-019001-ralxw4ad	182	38	149	149	CD
cord-019001-ralxw4ad	182	39	]	]	-RRB-
cord-019001-ralxw4ad	183	1	[	[	-LRB-
cord-019001-ralxw4ad	183	2	150	150	CD
cord-019001-ralxw4ad	183	3	]	]	-RRB-
cord-019001-ralxw4ad	183	4	[	[	-LRB-
cord-019001-ralxw4ad	183	5	151	151	CD
cord-019001-ralxw4ad	183	6	]	]	-RRB-
cord-019001-ralxw4ad	183	7	[	[	-LRB-
cord-019001-ralxw4ad	183	8	152	152	CD
cord-019001-ralxw4ad	183	9	]	]	-RRB-
cord-019001-ralxw4ad	183	10	[	[	-LRB-
cord-019001-ralxw4ad	183	11	153	153	CD
cord-019001-ralxw4ad	183	12	]	]	-RRB-
cord-019001-ralxw4ad	183	13	[	[	-LRB-
cord-019001-ralxw4ad	183	14	154	154	CD
cord-019001-ralxw4ad	183	15	]	]	-RRB-
cord-019001-ralxw4ad	183	16	[	[	-LRB-
cord-019001-ralxw4ad	183	17	155	155	CD
cord-019001-ralxw4ad	183	18	]	]	-RRB-
cord-019001-ralxw4ad	183	19	[	[	-LRB-
cord-019001-ralxw4ad	183	20	156	156	CD
cord-019001-ralxw4ad	183	21	]	]	-RRB-
cord-019001-ralxw4ad	183	22	.	.	.
cord-019001-ralxw4ad	184	1	Inhibitors	inhibitor	NNS
cord-019001-ralxw4ad	184	2	of	of	IN
cord-019001-ralxw4ad	184	3	phosphodiesterases	phosphodiesterase	NNS
cord-019001-ralxw4ad	184	4	(	(	-LRB-
cord-019001-ralxw4ad	184	5	PDEs	PDEs	NNP
cord-019001-ralxw4ad	184	6	)	)	-RRB-
cord-019001-ralxw4ad	184	7	,	,	,
cord-019001-ralxw4ad	184	8	a	a	DT
cord-019001-ralxw4ad	184	9	family	family	NN
cord-019001-ralxw4ad	184	10	of	of	IN
cord-019001-ralxw4ad	184	11	enzymes	enzyme	NNS
cord-019001-ralxw4ad	184	12	that	that	WDT
cord-019001-ralxw4ad	184	13	hydrolyze	hydrolyze	VBP
cord-019001-ralxw4ad	184	14	the	the	DT
cord-019001-ralxw4ad	184	15	cyclic	cyclic	JJ
cord-019001-ralxw4ad	184	16	nucleotides	nucleotide	NNS
cord-019001-ralxw4ad	184	17	cAMP	camp	NN
cord-019001-ralxw4ad	184	18	and	and	CC
cord-019001-ralxw4ad	184	19	cGMP	cGMP	NNP
cord-019001-ralxw4ad	184	20	,	,	,
cord-019001-ralxw4ad	184	21	are	be	VBP
cord-019001-ralxw4ad	184	22	a	a	DT
cord-019001-ralxw4ad	184	23	relatively	relatively	RB
cord-019001-ralxw4ad	184	24	new	new	JJ
cord-019001-ralxw4ad	184	25	class	class	NN
cord-019001-ralxw4ad	184	26	of	of	IN
cord-019001-ralxw4ad	184	27	agents	agent	NNS
cord-019001-ralxw4ad	184	28	that	that	WDT
cord-019001-ralxw4ad	184	29	have	have	VBP
cord-019001-ralxw4ad	184	30	potent	potent	JJ
cord-019001-ralxw4ad	184	31	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	184	32	and	and	CC
cord-019001-ralxw4ad	184	33	inotropic	inotropic	JJ
cord-019001-ralxw4ad	184	34	effects	effect	NNS
cord-019001-ralxw4ad	184	35	[	[	-LRB-
cord-019001-ralxw4ad	184	36	157	157	CD
cord-019001-ralxw4ad	184	37	]	]	-RRB-
cord-019001-ralxw4ad	184	38	.	.	.
cord-019001-ralxw4ad	185	1	Milrinone	Milrinone	NNP
cord-019001-ralxw4ad	185	2	is	be	VBZ
cord-019001-ralxw4ad	185	3	a	a	DT
cord-019001-ralxw4ad	185	4	PDE	PDE	NNP
cord-019001-ralxw4ad	185	5	3	3	CD
cord-019001-ralxw4ad	185	6	inhibitor	inhibitor	NN
cord-019001-ralxw4ad	185	7	that	that	WDT
cord-019001-ralxw4ad	185	8	increases	increase	VBZ
cord-019001-ralxw4ad	185	9	cAMP	camp	NN
cord-019001-ralxw4ad	185	10	concentrations	concentration	NNS
cord-019001-ralxw4ad	185	11	.	.	.
cord-019001-ralxw4ad	186	1	Animal	animal	NN
cord-019001-ralxw4ad	186	2	and	and	CC
cord-019001-ralxw4ad	186	3	human	human	JJ
cord-019001-ralxw4ad	186	4	data	datum	NNS
cord-019001-ralxw4ad	186	5	demonstrate	demonstrate	VBP
cord-019001-ralxw4ad	186	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	186	7	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	186	8	in	in	IN
cord-019001-ralxw4ad	186	9	response	response	NN
cord-019001-ralxw4ad	186	10	to	to	IN
cord-019001-ralxw4ad	186	11	milrinone	milrinone	NNP
cord-019001-ralxw4ad	186	12	that	that	WDT
cord-019001-ralxw4ad	186	13	can	can	MD
cord-019001-ralxw4ad	186	14	be	be	VB
cord-019001-ralxw4ad	186	15	in	in	IN
cord-019001-ralxw4ad	186	16	excess	excess	NN
cord-019001-ralxw4ad	186	17	of	of	IN
cord-019001-ralxw4ad	186	18	its	-PRON-	PRP$
cord-019001-ralxw4ad	186	19	systemic	systemic	JJ
cord-019001-ralxw4ad	186	20	effects	effect	NNS
cord-019001-ralxw4ad	186	21	if	if	IN
cord-019001-ralxw4ad	186	22	the	the	DT
cord-019001-ralxw4ad	186	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	186	24	vasculature	vasculature	NN
cord-019001-ralxw4ad	186	25	is	be	VBZ
cord-019001-ralxw4ad	186	26	constricted	constrict	VBN
cord-019001-ralxw4ad	186	27	[	[	-LRB-
cord-019001-ralxw4ad	186	28	158	158	CD
cord-019001-ralxw4ad	186	29	]	]	-RRB-
cord-019001-ralxw4ad	186	30	[	[	-LRB-
cord-019001-ralxw4ad	186	31	159	159	CD
cord-019001-ralxw4ad	186	32	]	]	-RRB-
cord-019001-ralxw4ad	186	33	[	[	-LRB-
cord-019001-ralxw4ad	186	34	160	160	CD
cord-019001-ralxw4ad	186	35	]	]	-RRB-
cord-019001-ralxw4ad	186	36	[	[	-LRB-
cord-019001-ralxw4ad	186	37	161	161	CD
cord-019001-ralxw4ad	186	38	]	]	-RRB-
cord-019001-ralxw4ad	186	39	.	.	.
cord-019001-ralxw4ad	187	1	In	in	IN
cord-019001-ralxw4ad	187	2	addition	addition	NN
cord-019001-ralxw4ad	187	3	,	,	,
cord-019001-ralxw4ad	187	4	a	a	DT
cord-019001-ralxw4ad	187	5	large	large	JJ
cord-019001-ralxw4ad	187	6	,	,	,
cord-019001-ralxw4ad	187	7	randomized	randomized	JJ
cord-019001-ralxw4ad	187	8	study	study	NN
cord-019001-ralxw4ad	187	9	demonstrates	demonstrate	VBZ
cord-019001-ralxw4ad	187	10	that	that	IN
cord-019001-ralxw4ad	187	11	its	-PRON-	PRP$
cord-019001-ralxw4ad	187	12	use	use	NN
cord-019001-ralxw4ad	187	13	decreases	decrease	VBZ
cord-019001-ralxw4ad	187	14	the	the	DT
cord-019001-ralxw4ad	187	15	incidence	incidence	NN
cord-019001-ralxw4ad	187	16	of	of	IN
cord-019001-ralxw4ad	187	17	low	low	JJ
cord-019001-ralxw4ad	187	18	cardiac	cardiac	JJ
cord-019001-ralxw4ad	187	19	output	output	NN
cord-019001-ralxw4ad	187	20	syndrome	syndrome	NN
cord-019001-ralxw4ad	187	21	following	follow	VBG
cord-019001-ralxw4ad	187	22	surgery	surgery	NN
cord-019001-ralxw4ad	187	23	for	for	IN
cord-019001-ralxw4ad	187	24	congenital	congenital	JJ
cord-019001-ralxw4ad	187	25	heart	heart	NN
cord-019001-ralxw4ad	187	26	disease	disease	NN
cord-019001-ralxw4ad	187	27	[	[	-LRB-
cord-019001-ralxw4ad	187	28	162	162	CD
cord-019001-ralxw4ad	187	29	]	]	-RRB-
cord-019001-ralxw4ad	187	30	.	.	.
cord-019001-ralxw4ad	188	1	Given	give	VBN
cord-019001-ralxw4ad	188	2	these	these	DT
cord-019001-ralxw4ad	188	3	properties	property	NNS
cord-019001-ralxw4ad	188	4	,	,	,
cord-019001-ralxw4ad	188	5	milrinone	milrinone	NNP
cord-019001-ralxw4ad	188	6	is	be	VBZ
cord-019001-ralxw4ad	188	7	increasingly	increasingly	RB
cord-019001-ralxw4ad	188	8	utilized	utilize	VBN
cord-019001-ralxw4ad	188	9	in	in	IN
cord-019001-ralxw4ad	188	10	the	the	DT
cord-019001-ralxw4ad	188	11	postoperative	postoperative	JJ
cord-019001-ralxw4ad	188	12	management	management	NN
cord-019001-ralxw4ad	188	13	of	of	IN
cord-019001-ralxw4ad	188	14	patients	patient	NNS
cord-019001-ralxw4ad	188	15	with	with	IN
cord-019001-ralxw4ad	188	16	congenital	congenital	JJ
cord-019001-ralxw4ad	188	17	heart	heart	NN
cord-019001-ralxw4ad	188	18	disease	disease	NN
cord-019001-ralxw4ad	188	19	and	and	CC
cord-019001-ralxw4ad	188	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	188	21	hypertension	hypertension	NN
cord-019001-ralxw4ad	188	22	.	.	.
cord-019001-ralxw4ad	189	1	Sildenafi	Sildenafi	NNP
cord-019001-ralxw4ad	189	2	l	l	NNP
cord-019001-ralxw4ad	189	3	,	,	,
cord-019001-ralxw4ad	189	4	a	a	DT
cord-019001-ralxw4ad	189	5	PDE5	PDE5	NNP
cord-019001-ralxw4ad	189	6	inhibitor	inhibitor	NN
cord-019001-ralxw4ad	189	7	,	,	,
cord-019001-ralxw4ad	189	8	which	which	WDT
cord-019001-ralxw4ad	189	9	increases	increase	VBZ
cord-019001-ralxw4ad	189	10	cGMP	cGMP	NNP
cord-019001-ralxw4ad	189	11	concentrations	concentration	NNS
cord-019001-ralxw4ad	189	12	,	,	,
cord-019001-ralxw4ad	189	13	also	also	RB
cord-019001-ralxw4ad	189	14	has	have	VBZ
cord-019001-ralxw4ad	189	15	potent	potent	JJ
cord-019001-ralxw4ad	189	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	189	17	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	189	18	effects	effect	NNS
cord-019001-ralxw4ad	189	19	[	[	-LRB-
cord-019001-ralxw4ad	189	20	163	163	CD
cord-019001-ralxw4ad	189	21	]	]	-RRB-
cord-019001-ralxw4ad	189	22	.	.	.
cord-019001-ralxw4ad	190	1	The	the	DT
cord-019001-ralxw4ad	190	2	oral	oral	JJ
cord-019001-ralxw4ad	190	3	formulation	formulation	NN
cord-019001-ralxw4ad	190	4	is	be	VBZ
cord-019001-ralxw4ad	190	5	currently	currently	RB
cord-019001-ralxw4ad	190	6	being	be	VBG
cord-019001-ralxw4ad	190	7	investigated	investigate	VBN
cord-019001-ralxw4ad	190	8	for	for	IN
cord-019001-ralxw4ad	190	9	chronic	chronic	JJ
cord-019001-ralxw4ad	190	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	190	11	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	190	12	therapy	therapy	NN
cord-019001-ralxw4ad	190	13	,	,	,
cord-019001-ralxw4ad	190	14	and	and	CC
cord-019001-ralxw4ad	190	15	recent	recent	JJ
cord-019001-ralxw4ad	190	16	short	short	JJ
cord-019001-ralxw4ad	190	17	-	-	HYPH
cord-019001-ralxw4ad	190	18	term	term	NN
cord-019001-ralxw4ad	190	19	studies	study	NNS
cord-019001-ralxw4ad	190	20	demonstrate	demonstrate	VBP
cord-019001-ralxw4ad	190	21	benefi	benefi	NNP
cord-019001-ralxw4ad	190	22	cial	cial	JJ
cord-019001-ralxw4ad	190	23	effects	effect	NNS
cord-019001-ralxw4ad	190	24	in	in	IN
cord-019001-ralxw4ad	190	25	children	child	NNS
cord-019001-ralxw4ad	190	26	with	with	IN
cord-019001-ralxw4ad	190	27	advanced	advanced	JJ
cord-019001-ralxw4ad	190	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	190	29	vascular	vascular	JJ
cord-019001-ralxw4ad	190	30	disease	disease	NN
cord-019001-ralxw4ad	190	31	[	[	-LRB-
cord-019001-ralxw4ad	190	32	164	164	CD
cord-019001-ralxw4ad	190	33	]	]	-RRB-
cord-019001-ralxw4ad	190	34	.	.	.
cord-019001-ralxw4ad	191	1	The	the	DT
cord-019001-ralxw4ad	191	2	intravenous	intravenous	JJ
cord-019001-ralxw4ad	191	3	formulation	formulation	NN
cord-019001-ralxw4ad	191	4	is	be	VBZ
cord-019001-ralxw4ad	191	5	currently	currently	RB
cord-019001-ralxw4ad	191	6	being	be	VBG
cord-019001-ralxw4ad	191	7	investigated	investigate	VBN
cord-019001-ralxw4ad	191	8	for	for	IN
cord-019001-ralxw4ad	191	9	acute	acute	JJ
cord-019001-ralxw4ad	191	10	pediatric	pediatric	JJ
cord-019001-ralxw4ad	191	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	191	12	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	191	13	disorders	disorder	NNS
cord-019001-ralxw4ad	191	14	(	(	-LRB-
cord-019001-ralxw4ad	191	15	PPHN	PPHN	NNS
cord-019001-ralxw4ad	191	16	and	and	CC
cord-019001-ralxw4ad	191	17	perioperative	perioperative	JJ
cord-019001-ralxw4ad	191	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	191	19	hypertension	hypertension	NN
cord-019001-ralxw4ad	191	20	)	)	-RRB-
cord-019001-ralxw4ad	191	21	[	[	-LRB-
cord-019001-ralxw4ad	191	22	165	165	CD
cord-019001-ralxw4ad	191	23	,	,	,
cord-019001-ralxw4ad	191	24	166	166	CD
cord-019001-ralxw4ad	191	25	]	]	-RRB-
cord-019001-ralxw4ad	191	26	.	.	.
cord-019001-ralxw4ad	192	1	Increasing	increase	VBG
cord-019001-ralxw4ad	192	2	data	datum	NNS
cord-019001-ralxw4ad	192	3	implicate	implicate	VBP
cord-019001-ralxw4ad	192	4	alterations	alteration	NNS
cord-019001-ralxw4ad	192	5	in	in	IN
cord-019001-ralxw4ad	192	6	ET-1	ET-1	NNP
cord-019001-ralxw4ad	192	7	in	in	IN
cord-019001-ralxw4ad	192	8	the	the	DT
cord-019001-ralxw4ad	192	9	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	192	10	of	of	IN
cord-019001-ralxw4ad	192	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	192	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	192	13	(	(	-LRB-
cord-019001-ralxw4ad	192	14	see	see	VB
cord-019001-ralxw4ad	192	15	earlier	early	RBR
cord-019001-ralxw4ad	192	16	)	)	-RRB-
cord-019001-ralxw4ad	192	17	and	and	CC
cord-019001-ralxw4ad	192	18	suggest	suggest	VBP
cord-019001-ralxw4ad	192	19	that	that	IN
cord-019001-ralxw4ad	192	20	ET	et	NN
cord-019001-ralxw4ad	192	21	-	-	HYPH
cord-019001-ralxw4ad	192	22	receptor	receptor	NN
cord-019001-ralxw4ad	192	23	antagonism	antagonism	NN
cord-019001-ralxw4ad	192	24	may	may	MD
cord-019001-ralxw4ad	192	25	be	be	VB
cord-019001-ralxw4ad	192	26	a	a	DT
cord-019001-ralxw4ad	192	27	useful	useful	JJ
cord-019001-ralxw4ad	192	28	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	192	29	strategy	strategy	NN
cord-019001-ralxw4ad	192	30	[	[	-LRB-
cord-019001-ralxw4ad	192	31	24	24	CD
cord-019001-ralxw4ad	192	32	,	,	,
cord-019001-ralxw4ad	192	33	25	25	CD
cord-019001-ralxw4ad	192	34	,	,	,
cord-019001-ralxw4ad	192	35	54	54	CD
cord-019001-ralxw4ad	192	36	,	,	,
cord-019001-ralxw4ad	192	37	60	60	CD
cord-019001-ralxw4ad	192	38	,	,	,
cord-019001-ralxw4ad	192	39	97	97	CD
cord-019001-ralxw4ad	192	40	]	]	-RRB-
cord-019001-ralxw4ad	192	41	.	.	.
cord-019001-ralxw4ad	193	1	In	in	IN
cord-019001-ralxw4ad	193	2	fact	fact	NN
cord-019001-ralxw4ad	193	3	,	,	,
cord-019001-ralxw4ad	193	4	bosentan	bosentan	NNP
cord-019001-ralxw4ad	193	5	,	,	,
cord-019001-ralxw4ad	193	6	an	an	DT
cord-019001-ralxw4ad	193	7	oral	oral	JJ
cord-019001-ralxw4ad	193	8	combined	combine	VBN
cord-019001-ralxw4ad	193	9	ET	ET	NNP
cord-019001-ralxw4ad	193	10	A	A	NNP
cord-019001-ralxw4ad	193	11	and	and	CC
cord-019001-ralxw4ad	193	12	ET	ET	NNP
cord-019001-ralxw4ad	193	13	B	B	NNP
cord-019001-ralxw4ad	193	14	receptor	receptor	NN
cord-019001-ralxw4ad	193	15	antagonist	antagonist	NN
cord-019001-ralxw4ad	193	16	,	,	,
cord-019001-ralxw4ad	193	17	has	have	VBZ
cord-019001-ralxw4ad	193	18	demonstrated	demonstrate	VBN
cord-019001-ralxw4ad	193	19	effi	effi	NNP
cord-019001-ralxw4ad	193	20	cacy	cacy	NNP
cord-019001-ralxw4ad	193	21	as	as	IN
cord-019001-ralxw4ad	193	22	a	a	DT
cord-019001-ralxw4ad	193	23	chronic	chronic	JJ
cord-019001-ralxw4ad	193	24	therapy	therapy	NN
cord-019001-ralxw4ad	193	25	for	for	IN
cord-019001-ralxw4ad	193	26	advanced	advanced	JJ
cord-019001-ralxw4ad	193	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	193	28	vascular	vascular	JJ
cord-019001-ralxw4ad	193	29	disease	disease	NN
cord-019001-ralxw4ad	193	30	[	[	-LRB-
cord-019001-ralxw4ad	193	31	167	167	CD
cord-019001-ralxw4ad	193	32	,	,	,
cord-019001-ralxw4ad	193	33	168	168	CD
cord-019001-ralxw4ad	193	34	]	]	-RRB-
cord-019001-ralxw4ad	193	35	.	.	.
cord-019001-ralxw4ad	194	1	To	to	IN
cord-019001-ralxw4ad	194	2	date	date	NN
cord-019001-ralxw4ad	194	3	,	,	,
cord-019001-ralxw4ad	194	4	there	there	EX
cord-019001-ralxw4ad	194	5	have	have	VBP
cord-019001-ralxw4ad	194	6	been	be	VBN
cord-019001-ralxw4ad	194	7	no	no	DT
cord-019001-ralxw4ad	194	8	large	large	JJ
cord-019001-ralxw4ad	194	9	studies	study	NNS
cord-019001-ralxw4ad	194	10	on	on	IN
cord-019001-ralxw4ad	194	11	the	the	DT
cord-019001-ralxw4ad	194	12	use	use	NN
cord-019001-ralxw4ad	194	13	of	of	IN
cord-019001-ralxw4ad	194	14	ET	ET	NNP
cord-019001-ralxw4ad	194	15	receptor	receptor	NN
cord-019001-ralxw4ad	194	16	antagonists	antagonist	NNS
cord-019001-ralxw4ad	194	17	for	for	IN
cord-019001-ralxw4ad	194	18	acute	acute	JJ
cord-019001-ralxw4ad	194	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	194	20	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	194	21	disorders	disorder	NNS
cord-019001-ralxw4ad	194	22	.	.	.
cord-019001-ralxw4ad	195	1	In	in	IN
cord-019001-ralxw4ad	195	2	addition	addition	NN
cord-019001-ralxw4ad	195	3	,	,	,
cord-019001-ralxw4ad	195	4	the	the	DT
cord-019001-ralxw4ad	195	5	use	use	NN
cord-019001-ralxw4ad	195	6	of	of	IN
cord-019001-ralxw4ad	195	7	selective	selective	JJ
cord-019001-ralxw4ad	195	8	ET	ET	NNP
cord-019001-ralxw4ad	195	9	receptor	receptor	NN
cord-019001-ralxw4ad	195	10	antagonism	antagonism	NN
cord-019001-ralxw4ad	195	11	is	be	VBZ
cord-019001-ralxw4ad	195	12	under	under	IN
cord-019001-ralxw4ad	195	13	investigation	investigation	NN
cord-019001-ralxw4ad	195	14	but	but	CC
cord-019001-ralxw4ad	195	15	has	have	VBZ
cord-019001-ralxw4ad	195	16	not	not	RB
cord-019001-ralxw4ad	195	17	yet	yet	RB
cord-019001-ralxw4ad	195	18	reached	reach	VBN
cord-019001-ralxw4ad	195	19	clinical	clinical	JJ
cord-019001-ralxw4ad	195	20	trials	trial	NNS
cord-019001-ralxw4ad	195	21	.	.	.
cord-019001-ralxw4ad	196	1	A	a	DT
cord-019001-ralxw4ad	196	2	signifi	signifi	NN
cord-019001-ralxw4ad	196	3	ca	can	MD
cord-019001-ralxw4ad	196	4	nt	not	RB
cord-019001-ralxw4ad	196	5	component	component	NN
cord-019001-ralxw4ad	196	6	of	of	IN
cord-019001-ralxw4ad	196	7	the	the	DT
cord-019001-ralxw4ad	196	8	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	196	9	of	of	IN
cord-019001-ralxw4ad	196	10	both	both	CC
cord-019001-ralxw4ad	196	11	acute	acute	JJ
cord-019001-ralxw4ad	196	12	and	and	CC
cord-019001-ralxw4ad	196	13	chronic	chronic	JJ
cord-019001-ralxw4ad	196	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	196	15	hypertension	hypertension	NN
cord-019001-ralxw4ad	196	16	is	be	VBZ
cord-019001-ralxw4ad	196	17	the	the	DT
cord-019001-ralxw4ad	196	18	development	development	NN
cord-019001-ralxw4ad	196	19	of	of	IN
cord-019001-ralxw4ad	196	20	right	right	JJ
cord-019001-ralxw4ad	196	21	ventricular	ventricular	JJ
cord-019001-ralxw4ad	196	22	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	196	23	,	,	,
cord-019001-ralxw4ad	196	24	which	which	WDT
cord-019001-ralxw4ad	196	25	often	often	RB
cord-019001-ralxw4ad	196	26	requires	require	VBZ
cord-019001-ralxw4ad	196	27	pharmacologic	pharmacologic	JJ
cord-019001-ralxw4ad	196	28	support	support	NN
cord-019001-ralxw4ad	196	29	.	.	.
cord-019001-ralxw4ad	197	1	Maintenance	maintenance	NN
cord-019001-ralxw4ad	197	2	of	of	IN
cord-019001-ralxw4ad	197	3	adequate	adequate	JJ
cord-019001-ralxw4ad	197	4	preload	preload	NN
cord-019001-ralxw4ad	197	5	is	be	VBZ
cord-019001-ralxw4ad	197	6	necessary	necessary	JJ
cord-019001-ralxw4ad	197	7	to	to	TO
cord-019001-ralxw4ad	197	8	optimize	optimize	VB
cord-019001-ralxw4ad	197	9	cardiac	cardiac	JJ
cord-019001-ralxw4ad	197	10	output	output	NN
cord-019001-ralxw4ad	197	11	in	in	IN
cord-019001-ralxw4ad	197	12	patients	patient	NNS
cord-019001-ralxw4ad	197	13	with	with	IN
cord-019001-ralxw4ad	197	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	197	15	hypertension	hypertension	NN
cord-019001-ralxw4ad	197	16	.	.	.
cord-019001-ralxw4ad	198	1	Continuous	continuous	JJ
cord-019001-ralxw4ad	198	2	central	central	JJ
cord-019001-ralxw4ad	198	3	venous	venous	JJ
cord-019001-ralxw4ad	198	4	pressure	pressure	NN
cord-019001-ralxw4ad	198	5	monitoring	monitoring	NN
cord-019001-ralxw4ad	198	6	may	may	MD
cord-019001-ralxw4ad	198	7	be	be	VB
cord-019001-ralxw4ad	198	8	helpful	helpful	JJ
cord-019001-ralxw4ad	198	9	to	to	TO
cord-019001-ralxw4ad	198	10	guide	guide	VB
cord-019001-ralxw4ad	198	11	volume	volume	NN
cord-019001-ralxw4ad	198	12	therapy	therapy	NN
cord-019001-ralxw4ad	198	13	,	,	,
cord-019001-ralxw4ad	198	14	keeping	keep	VBG
cord-019001-ralxw4ad	198	15	in	in	IN
cord-019001-ralxw4ad	198	16	mind	mind	NN
cord-019001-ralxw4ad	198	17	that	that	IN
cord-019001-ralxw4ad	198	18	patients	patient	NNS
cord-019001-ralxw4ad	198	19	with	with	IN
cord-019001-ralxw4ad	198	20	a	a	DT
cord-019001-ralxw4ad	198	21	poorly	poorly	RB
cord-019001-ralxw4ad	198	22	compliant	compliant	JJ
cord-019001-ralxw4ad	198	23	right	right	JJ
cord-019001-ralxw4ad	198	24	ventricle	ventricle	NN
cord-019001-ralxw4ad	198	25	or	or	CC
cord-019001-ralxw4ad	198	26	increased	increase	VBN
cord-019001-ralxw4ad	198	27	right	right	JJ
cord-019001-ralxw4ad	198	28	ventricular	ventricular	JJ
cord-019001-ralxw4ad	198	29	afterload	afterload	NN
cord-019001-ralxw4ad	198	30	may	may	MD
cord-019001-ralxw4ad	198	31	require	require	VB
cord-019001-ralxw4ad	198	32	elevated	elevated	JJ
cord-019001-ralxw4ad	198	33	central	central	JJ
cord-019001-ralxw4ad	198	34	venous	venous	JJ
cord-019001-ralxw4ad	198	35	pressures	pressure	NNS
cord-019001-ralxw4ad	198	36	to	to	TO
cord-019001-ralxw4ad	198	37	maintain	maintain	VB
cord-019001-ralxw4ad	198	38	an	an	DT
cord-019001-ralxw4ad	198	39	adequate	adequate	JJ
cord-019001-ralxw4ad	198	40	cardiac	cardiac	JJ
cord-019001-ralxw4ad	198	41	output	output	NN
cord-019001-ralxw4ad	198	42	.	.	.
cord-019001-ralxw4ad	199	1	Frequent	frequent	JJ
cord-019001-ralxw4ad	199	2	clinical	clinical	JJ
cord-019001-ralxw4ad	199	3	assessment	assessment	NN
cord-019001-ralxw4ad	199	4	of	of	IN
cord-019001-ralxw4ad	199	5	liver	liver	NN
cord-019001-ralxw4ad	199	6	size	size	NN
cord-019001-ralxw4ad	199	7	can	can	MD
cord-019001-ralxw4ad	199	8	be	be	VB
cord-019001-ralxw4ad	199	9	helpful	helpful	JJ
cord-019001-ralxw4ad	199	10	,	,	,
cord-019001-ralxw4ad	199	11	particularly	particularly	RB
cord-019001-ralxw4ad	199	12	in	in	IN
cord-019001-ralxw4ad	199	13	infants	infant	NNS
cord-019001-ralxw4ad	199	14	.	.	.
cord-019001-ralxw4ad	200	1	Despite	despite	IN
cord-019001-ralxw4ad	200	2	adequate	adequate	JJ
cord-019001-ralxw4ad	200	3	preload	preload	NN
cord-019001-ralxw4ad	200	4	,	,	,
cord-019001-ralxw4ad	200	5	cardiac	cardiac	JJ
cord-019001-ralxw4ad	200	6	output	output	NN
cord-019001-ralxw4ad	200	7	may	may	MD
cord-019001-ralxw4ad	200	8	be	be	VB
cord-019001-ralxw4ad	200	9	compromised	compromise	VBN
cord-019001-ralxw4ad	200	10	secondary	secondary	JJ
cord-019001-ralxw4ad	200	11	to	to	IN
cord-019001-ralxw4ad	200	12	elevated	elevate	VBN
cord-019001-ralxw4ad	200	13	right	right	JJ
cord-019001-ralxw4ad	200	14	ventricular	ventricular	JJ
cord-019001-ralxw4ad	200	15	afterload	afterload	NN
cord-019001-ralxw4ad	200	16	and/or	and/or	CC
cord-019001-ralxw4ad	200	17	biventricular	biventricular	JJ
cord-019001-ralxw4ad	200	18	myocardial	myocardial	JJ
cord-019001-ralxw4ad	200	19	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	200	20	after	after	IN
cord-019001-ralxw4ad	200	21	cardiac	cardiac	JJ
cord-019001-ralxw4ad	200	22	surgery	surgery	NN
cord-019001-ralxw4ad	200	23	and	and	CC
cord-019001-ralxw4ad	200	24	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	200	25	bypass	bypass	NN
cord-019001-ralxw4ad	200	26	,	,	,
cord-019001-ralxw4ad	200	27	necessitating	necessitate	VBG
cord-019001-ralxw4ad	200	28	the	the	DT
cord-019001-ralxw4ad	200	29	use	use	NN
cord-019001-ralxw4ad	200	30	of	of	IN
cord-019001-ralxw4ad	200	31	inotropic	inotropic	NNP
cord-019001-ralxw4ad	200	32	agents	agent	NNS
cord-019001-ralxw4ad	200	33	[	[	-LRB-
cord-019001-ralxw4ad	200	34	111	111	CD
cord-019001-ralxw4ad	200	35	,	,	,
cord-019001-ralxw4ad	200	36	169	169	CD
cord-019001-ralxw4ad	200	37	]	]	-RRB-
cord-019001-ralxw4ad	200	38	.	.	.
cord-019001-ralxw4ad	201	1	These	these	DT
cord-019001-ralxw4ad	201	2	agents	agent	NNS
cord-019001-ralxw4ad	201	3	increase	increase	VBP
cord-019001-ralxw4ad	201	4	stroke	stroke	NN
cord-019001-ralxw4ad	201	5	volume	volume	NN
cord-019001-ralxw4ad	201	6	at	at	IN
cord-019001-ralxw4ad	201	7	a	a	DT
cord-019001-ralxw4ad	201	8	given	give	VBN
cord-019001-ralxw4ad	201	9	preload	preload	NN
cord-019001-ralxw4ad	201	10	and	and	CC
cord-019001-ralxw4ad	201	11	afterload	afterload	NN
cord-019001-ralxw4ad	201	12	by	by	IN
cord-019001-ralxw4ad	201	13	stimulating	stimulate	VBG
cord-019001-ralxw4ad	201	14	ß	ß	NN
cord-019001-ralxw4ad	201	15	1	1	CD
cord-019001-ralxw4ad	201	16	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	201	17	receptors	receptor	NNS
cord-019001-ralxw4ad	201	18	[	[	-LRB-
cord-019001-ralxw4ad	201	19	170	170	CD
cord-019001-ralxw4ad	201	20	,	,	,
cord-019001-ralxw4ad	201	21	171	171	CD
cord-019001-ralxw4ad	201	22	]	]	-RRB-
cord-019001-ralxw4ad	201	23	.	.	.
cord-019001-ralxw4ad	202	1	However	however	RB
cord-019001-ralxw4ad	202	2	,	,	,
cord-019001-ralxw4ad	202	3	some	some	DT
cord-019001-ralxw4ad	202	4	of	of	IN
cord-019001-ralxw4ad	202	5	these	these	DT
cord-019001-ralxw4ad	202	6	agents	agent	NNS
cord-019001-ralxw4ad	202	7	also	also	RB
cord-019001-ralxw4ad	202	8	stimulate	stimulate	VBP
cord-019001-ralxw4ad	202	9	ß	ß	NN
cord-019001-ralxw4ad	202	10	2	2	CD
cord-019001-ralxw4ad	202	11	-or	-or	:
cord-019001-ralxw4ad	202	12	α	α	NN
cord-019001-ralxw4ad	202	13	1	1	CD
cord-019001-ralxw4ad	202	14	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	202	15	receptors	receptor	NNS
cord-019001-ralxw4ad	202	16	,	,	,
cord-019001-ralxw4ad	202	17	which	which	WDT
cord-019001-ralxw4ad	202	18	are	be	VBP
cord-019001-ralxw4ad	202	19	found	find	VBN
cord-019001-ralxw4ad	202	20	on	on	IN
cord-019001-ralxw4ad	202	21	the	the	DT
cord-019001-ralxw4ad	202	22	smooth	smooth	JJ
cord-019001-ralxw4ad	202	23	muscle	muscle	NN
cord-019001-ralxw4ad	202	24	cells	cell	NNS
cord-019001-ralxw4ad	202	25	of	of	IN
cord-019001-ralxw4ad	202	26	both	both	CC
cord-019001-ralxw4ad	202	27	the	the	DT
cord-019001-ralxw4ad	202	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	202	29	and	and	CC
cord-019001-ralxw4ad	202	30	systemic	systemic	JJ
cord-019001-ralxw4ad	202	31	arteries	artery	NNS
cord-019001-ralxw4ad	202	32	.	.	.
cord-019001-ralxw4ad	203	1	Agents	agent	NNS
cord-019001-ralxw4ad	203	2	that	that	WDT
cord-019001-ralxw4ad	203	3	stimulate	stimulate	VBP
cord-019001-ralxw4ad	203	4	ß	ß	NN
cord-019001-ralxw4ad	203	5	2	2	CD
cord-019001-ralxw4ad	203	6	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	203	7	receptors	receptor	NNS
cord-019001-ralxw4ad	203	8	decrease	decrease	VBP
cord-019001-ralxw4ad	203	9	both	both	CC
cord-019001-ralxw4ad	203	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	203	11	and	and	CC
cord-019001-ralxw4ad	203	12	systemic	systemic	JJ
cord-019001-ralxw4ad	203	13	vascular	vascular	JJ
cord-019001-ralxw4ad	203	14	resistance	resistance	NN
cord-019001-ralxw4ad	203	15	and	and	CC
cord-019001-ralxw4ad	203	16	improve	improve	VB
cord-019001-ralxw4ad	203	17	right	right	RB
cord-019001-ralxw4ad	203	18	and	and	CC
cord-019001-ralxw4ad	203	19	left	left	JJ
cord-019001-ralxw4ad	203	20	ventricular	ventricular	JJ
cord-019001-ralxw4ad	203	21	function	function	NN
cord-019001-ralxw4ad	203	22	[	[	-LRB-
cord-019001-ralxw4ad	203	23	172	172	CD
cord-019001-ralxw4ad	203	24	,	,	,
cord-019001-ralxw4ad	203	25	173	173	CD
cord-019001-ralxw4ad	203	26	]	]	-RRB-
cord-019001-ralxw4ad	203	27	.	.	.
cord-019001-ralxw4ad	204	1	Agents	agent	NNS
cord-019001-ralxw4ad	204	2	that	that	WDT
cord-019001-ralxw4ad	204	3	stimulate	stimulate	VBP
cord-019001-ralxw4ad	204	4	α	α	NN
cord-019001-ralxw4ad	204	5	1	1	CD
cord-019001-ralxw4ad	204	6	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	204	7	receptors	receptor	NNS
cord-019001-ralxw4ad	204	8	may	may	MD
cord-019001-ralxw4ad	204	9	increase	increase	VB
cord-019001-ralxw4ad	204	10	both	both	DT
cord-019001-ralxw4ad	204	11	systemic	systemic	JJ
cord-019001-ralxw4ad	204	12	and	and	CC
cord-019001-ralxw4ad	204	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	204	14	vascular	vascular	JJ
cord-019001-ralxw4ad	204	15	resistance	resistance	NN
cord-019001-ralxw4ad	204	16	.	.	.
cord-019001-ralxw4ad	205	1	Therefore	therefore	RB
cord-019001-ralxw4ad	205	2	,	,	,
cord-019001-ralxw4ad	205	3	a	a	DT
cord-019001-ralxw4ad	205	4	rational	rational	JJ
cord-019001-ralxw4ad	205	5	approach	approach	NN
cord-019001-ralxw4ad	205	6	to	to	IN
cord-019001-ralxw4ad	205	7	using	use	VBG
cord-019001-ralxw4ad	205	8	inotropic	inotropic	NNP
cord-019001-ralxw4ad	205	9	agents	agent	NNS
cord-019001-ralxw4ad	205	10	in	in	IN
cord-019001-ralxw4ad	205	11	the	the	DT
cord-019001-ralxw4ad	205	12	setting	setting	NN
cord-019001-ralxw4ad	205	13	of	of	IN
cord-019001-ralxw4ad	205	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	205	15	hypertension	hypertension	NN
cord-019001-ralxw4ad	205	16	is	be	VBZ
cord-019001-ralxw4ad	205	17	to	to	TO
cord-019001-ralxw4ad	205	18	utilize	utilize	VB
cord-019001-ralxw4ad	205	19	agents	agent	NNS
cord-019001-ralxw4ad	205	20	with	with	IN
cord-019001-ralxw4ad	205	21	ß	ß	CD
cord-019001-ralxw4ad	205	22	2	2	CD
cord-019001-ralxw4ad	205	23	-receptor	-receptor	NN
cord-019001-ralxw4ad	205	24	selectivity	selectivity	NN
cord-019001-ralxw4ad	205	25	and	and	CC
cord-019001-ralxw4ad	205	26	minimal	minimal	JJ
cord-019001-ralxw4ad	205	27	α	α	NN
cord-019001-ralxw4ad	205	28	1	1	CD
cord-019001-ralxw4ad	205	29	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	205	30	stimulation	stimulation	NN
cord-019001-ralxw4ad	205	31	(	(	-LRB-
cord-019001-ralxw4ad	205	32	i.e.	i.e.	FW
cord-019001-ralxw4ad	205	33	,	,	,
cord-019001-ralxw4ad	205	34	dobutamine	dobutamine	NN
cord-019001-ralxw4ad	205	35	)	)	-RRB-
cord-019001-ralxw4ad	205	36	.	.	.
cord-019001-ralxw4ad	206	1	Although	although	IN
cord-019001-ralxw4ad	206	2	animal	animal	NN
cord-019001-ralxw4ad	206	3	studies	study	NNS
cord-019001-ralxw4ad	206	4	have	have	VBP
cord-019001-ralxw4ad	206	5	shown	show	VBN
cord-019001-ralxw4ad	206	6	that	that	IN
cord-019001-ralxw4ad	206	7	high	high	JJ
cord-019001-ralxw4ad	206	8	doses	dose	NNS
cord-019001-ralxw4ad	206	9	of	of	IN
cord-019001-ralxw4ad	206	10	dopamine	dopamine	NN
cord-019001-ralxw4ad	206	11	increase	increase	VBP
cord-019001-ralxw4ad	206	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	206	13	vascular	vascular	JJ
cord-019001-ralxw4ad	206	14	resistance	resistance	NN
cord-019001-ralxw4ad	206	15	,	,	,
cord-019001-ralxw4ad	206	16	human	human	JJ
cord-019001-ralxw4ad	206	17	studies	study	NNS
cord-019001-ralxw4ad	206	18	have	have	VBP
cord-019001-ralxw4ad	206	19	shown	show	VBN
cord-019001-ralxw4ad	206	20	increased	increase	VBN
cord-019001-ralxw4ad	206	21	cardiac	cardiac	JJ
cord-019001-ralxw4ad	206	22	output	output	NN
cord-019001-ralxw4ad	206	23	with	with	IN
cord-019001-ralxw4ad	206	24	minimal	minimal	JJ
cord-019001-ralxw4ad	206	25	effects	effect	NNS
cord-019001-ralxw4ad	206	26	on	on	IN
cord-019001-ralxw4ad	206	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	206	28	vascular	vascular	JJ
cord-019001-ralxw4ad	206	29	resistance	resistance	NN
cord-019001-ralxw4ad	206	30	[	[	-LRB-
cord-019001-ralxw4ad	206	31	130	130	CD
cord-019001-ralxw4ad	206	32	,	,	,
cord-019001-ralxw4ad	206	33	174	174	CD
cord-019001-ralxw4ad	206	34	]	]	-RRB-
cord-019001-ralxw4ad	206	35	.	.	.
cord-019001-ralxw4ad	207	1	Milrinone	Milrinone	NNP
cord-019001-ralxw4ad	207	2	is	be	VBZ
cord-019001-ralxw4ad	207	3	also	also	RB
cord-019001-ralxw4ad	207	4	a	a	DT
cord-019001-ralxw4ad	207	5	useful	useful	JJ
cord-019001-ralxw4ad	207	6	therapy	therapy	NN
cord-019001-ralxw4ad	207	7	for	for	IN
cord-019001-ralxw4ad	207	8	patients	patient	NNS
cord-019001-ralxw4ad	207	9	with	with	IN
cord-019001-ralxw4ad	207	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	207	11	hypertension	hypertension	NN
cord-019001-ralxw4ad	207	12	and	and	CC
cord-019001-ralxw4ad	207	13	myocardial	myocardial	JJ
cord-019001-ralxw4ad	207	14	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	207	15	,	,	,
cord-019001-ralxw4ad	207	16	given	give	VBN
cord-019001-ralxw4ad	207	17	its	-PRON-	PRP$
cord-019001-ralxw4ad	207	18	vasodilatory	vasodilatory	NN
cord-019001-ralxw4ad	207	19	and	and	CC
cord-019001-ralxw4ad	207	20	inotropic	inotropic	NNP
cord-019001-ralxw4ad	207	21	properties	property	NNS
cord-019001-ralxw4ad	207	22	[	[	-LRB-
cord-019001-ralxw4ad	207	23	162	162	CD
cord-019001-ralxw4ad	207	24	]	]	-RRB-
cord-019001-ralxw4ad	207	25	.	.	.
cord-019001-ralxw4ad	208	1	In	in	IN
cord-019001-ralxw4ad	208	2	the	the	DT
cord-019001-ralxw4ad	208	3	setting	setting	NN
cord-019001-ralxw4ad	208	4	of	of	IN
cord-019001-ralxw4ad	208	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	208	6	hypertension	hypertension	NN
cord-019001-ralxw4ad	208	7	secondary	secondary	JJ
cord-019001-ralxw4ad	208	8	to	to	IN
cord-019001-ralxw4ad	208	9	congenital	congenital	JJ
cord-019001-ralxw4ad	208	10	heart	heart	NN
cord-019001-ralxw4ad	208	11	defects	defect	NNS
cord-019001-ralxw4ad	208	12	,	,	,
cord-019001-ralxw4ad	208	13	an	an	DT
cord-019001-ralxw4ad	208	14	atrial	atrial	JJ
cord-019001-ralxw4ad	208	15	communication	communication	NN
cord-019001-ralxw4ad	208	16	can	can	MD
cord-019001-ralxw4ad	208	17	be	be	VB
cord-019001-ralxw4ad	208	18	benefi	benefi	NNP
cord-019001-ralxw4ad	208	19	cial	cial	NN
cord-019001-ralxw4ad	208	20	in	in	IN
cord-019001-ralxw4ad	208	21	that	that	IN
cord-019001-ralxw4ad	208	22	it	-PRON-	PRP
cord-019001-ralxw4ad	208	23	allows	allow	VBZ
cord-019001-ralxw4ad	208	24	the	the	DT
cord-019001-ralxw4ad	208	25	failing	fail	VBG
cord-019001-ralxw4ad	208	26	right	right	JJ
cord-019001-ralxw4ad	208	27	ventricle	ventricle	NN
cord-019001-ralxw4ad	208	28	to	to	TO
cord-019001-ralxw4ad	208	29	decompress	decompress	VB
cord-019001-ralxw4ad	208	30	when	when	WRB
cord-019001-ralxw4ad	208	31	right	right	JJ
cord-019001-ralxw4ad	208	32	atrial	atrial	JJ
cord-019001-ralxw4ad	208	33	pressure	pressure	NN
cord-019001-ralxw4ad	208	34	rises	rise	VBZ
cord-019001-ralxw4ad	208	35	[	[	-LRB-
cord-019001-ralxw4ad	208	36	175	175	CD
cord-019001-ralxw4ad	208	37	]	]	-RRB-
cord-019001-ralxw4ad	208	38	.	.	.
cord-019001-ralxw4ad	209	1	Accordingly	accordingly	RB
cord-019001-ralxw4ad	209	2	,	,	,
cord-019001-ralxw4ad	209	3	atrial	atrial	JJ
cord-019001-ralxw4ad	209	4	septal	septal	JJ
cord-019001-ralxw4ad	209	5	defects	defect	NNS
cord-019001-ralxw4ad	209	6	can	can	MD
cord-019001-ralxw4ad	209	7	be	be	VB
cord-019001-ralxw4ad	209	8	left	leave	VBN
cord-019001-ralxw4ad	209	9	unclosed	unclosed	JJ
cord-019001-ralxw4ad	209	10	(	(	-LRB-
cord-019001-ralxw4ad	209	11	i.e.	i.e.	FW
cord-019001-ralxw4ad	209	12	,	,	,
cord-019001-ralxw4ad	209	13	patent	patent	NN
cord-019001-ralxw4ad	209	14	foramen	foramen	NN
cord-019001-ralxw4ad	209	15	ovale	ovale	NNP
cord-019001-ralxw4ad	209	16	)	)	-RRB-
cord-019001-ralxw4ad	209	17	or	or	CC
cord-019001-ralxw4ad	209	18	created	create	VBN
cord-019001-ralxw4ad	209	19	at	at	IN
cord-019001-ralxw4ad	209	20	the	the	DT
cord-019001-ralxw4ad	209	21	time	time	NN
cord-019001-ralxw4ad	209	22	of	of	IN
cord-019001-ralxw4ad	209	23	surgery	surgery	NN
cord-019001-ralxw4ad	209	24	.	.	.
cord-019001-ralxw4ad	210	1	The	the	DT
cord-019001-ralxw4ad	210	2	existence	existence	NN
cord-019001-ralxw4ad	210	3	of	of	IN
cord-019001-ralxw4ad	210	4	an	an	DT
cord-019001-ralxw4ad	210	5	atrial	atrial	JJ
cord-019001-ralxw4ad	210	6	level	level	NN
cord-019001-ralxw4ad	210	7	communication	communication	NN
cord-019001-ralxw4ad	210	8	decreases	decrease	VBZ
cord-019001-ralxw4ad	210	9	the	the	DT
cord-019001-ralxw4ad	210	10	risk	risk	NN
cord-019001-ralxw4ad	210	11	of	of	IN
cord-019001-ralxw4ad	210	12	right	right	JJ
cord-019001-ralxw4ad	210	13	ventricular	ventricular	JJ
cord-019001-ralxw4ad	210	14	failure	failure	NN
cord-019001-ralxw4ad	210	15	and	and	CC
cord-019001-ralxw4ad	210	16	maintains	maintain	VBZ
cord-019001-ralxw4ad	210	17	left	left	JJ
cord-019001-ralxw4ad	210	18	-	-	HYPH
cord-019001-ralxw4ad	210	19	sided	sided	JJ
cord-019001-ralxw4ad	210	20	cardiac	cardiac	JJ
cord-019001-ralxw4ad	210	21	output	output	NN
cord-019001-ralxw4ad	210	22	.	.	.
cord-019001-ralxw4ad	211	1	The	the	DT
cord-019001-ralxw4ad	211	2	resulting	result	VBG
cord-019001-ralxw4ad	211	3	right	right	NN
cord-019001-ralxw4ad	211	4	-	-	HYPH
cord-019001-ralxw4ad	211	5	to	to	IN
cord-019001-ralxw4ad	211	6	-	-	HYPH
cord-019001-ralxw4ad	211	7	left	leave	VBN
cord-019001-ralxw4ad	211	8	shunt	shunt	NN
cord-019001-ralxw4ad	211	9	is	be	VBZ
cord-019001-ralxw4ad	211	10	generally	generally	RB
cord-019001-ralxw4ad	211	11	well	well	RB
cord-019001-ralxw4ad	211	12	tolerated	tolerate	VBN
cord-019001-ralxw4ad	211	13	,	,	,
cord-019001-ralxw4ad	211	14	particularly	particularly	RB
cord-019001-ralxw4ad	211	15	if	if	IN
cord-019001-ralxw4ad	211	16	high	high	JJ
cord-019001-ralxw4ad	211	17	hemoglobin	hemoglobin	NN
cord-019001-ralxw4ad	211	18	concentrations	concentration	NNS
cord-019001-ralxw4ad	211	19	are	be	VBP
cord-019001-ralxw4ad	211	20	maintained	maintain	VBN
cord-019001-ralxw4ad	211	21	.	.	.
cord-019001-ralxw4ad	212	1	As	as	IN
cord-019001-ralxw4ad	212	2	right	right	JJ
cord-019001-ralxw4ad	212	3	ventricular	ventricular	JJ
cord-019001-ralxw4ad	212	4	function	function	NN
cord-019001-ralxw4ad	212	5	improves	improve	VBZ
cord-019001-ralxw4ad	212	6	,	,	,
cord-019001-ralxw4ad	212	7	right	right	JJ
cord-019001-ralxw4ad	212	8	-	-	HYPH
cord-019001-ralxw4ad	212	9	to	to	IN
cord-019001-ralxw4ad	212	10	-	-	HYPH
cord-019001-ralxw4ad	212	11	left	leave	VBN
cord-019001-ralxw4ad	212	12	shunting	shunting	NN
cord-019001-ralxw4ad	212	13	decreases	decrease	NNS
cord-019001-ralxw4ad	212	14	and	and	CC
cord-019001-ralxw4ad	212	15	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	212	16	improves	improve	VBZ
cord-019001-ralxw4ad	212	17	.	.	.
cord-019001-ralxw4ad	213	1	Atrial	atrial	JJ
cord-019001-ralxw4ad	213	2	septostomy	septostomy	NN
cord-019001-ralxw4ad	213	3	as	as	IN
cord-019001-ralxw4ad	213	4	a	a	DT
cord-019001-ralxw4ad	213	5	part	part	NN
cord-019001-ralxw4ad	213	6	of	of	IN
cord-019001-ralxw4ad	213	7	management	management	NN
cord-019001-ralxw4ad	213	8	for	for	IN
cord-019001-ralxw4ad	213	9	chronic	chronic	JJ
cord-019001-ralxw4ad	213	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	213	11	hypertension	hypertension	NN
cord-019001-ralxw4ad	213	12	(	(	-LRB-
cord-019001-ralxw4ad	213	13	e.g.	e.g.	RB
cord-019001-ralxw4ad	213	14	,	,	,
cord-019001-ralxw4ad	213	15	primary	primary	JJ
cord-019001-ralxw4ad	213	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	213	17	hypertension	hypertension	NN
cord-019001-ralxw4ad	213	18	)	)	-RRB-
cord-019001-ralxw4ad	213	19	has	have	VBZ
cord-019001-ralxw4ad	213	20	been	be	VBN
cord-019001-ralxw4ad	213	21	advocated	advocate	VBN
cord-019001-ralxw4ad	213	22	but	but	CC
cord-019001-ralxw4ad	213	23	must	must	MD
cord-019001-ralxw4ad	213	24	be	be	VB
cord-019001-ralxw4ad	213	25	considered	consider	VBN
cord-019001-ralxw4ad	213	26	carefully	carefully	RB
cord-019001-ralxw4ad	213	27	on	on	IN
cord-019001-ralxw4ad	213	28	an	an	DT
cord-019001-ralxw4ad	213	29	individual	individual	JJ
cord-019001-ralxw4ad	213	30	basis	basis	NN
cord-019001-ralxw4ad	213	31	[	[	-LRB-
cord-019001-ralxw4ad	213	32	176	176	CD
cord-019001-ralxw4ad	213	33	]	]	-RRB-
cord-019001-ralxw4ad	213	34	[	[	-LRB-
cord-019001-ralxw4ad	213	35	177	177	CD
cord-019001-ralxw4ad	213	36	]	]	-RRB-
cord-019001-ralxw4ad	213	37	[	[	-LRB-
cord-019001-ralxw4ad	213	38	178	178	CD
cord-019001-ralxw4ad	213	39	]	]	-RRB-
cord-019001-ralxw4ad	213	40	[	[	-LRB-
cord-019001-ralxw4ad	213	41	179	179	CD
cord-019001-ralxw4ad	213	42	]	]	-RRB-
cord-019001-ralxw4ad	213	43	[	[	-LRB-
cord-019001-ralxw4ad	213	44	180	180	CD
cord-019001-ralxw4ad	213	45	]	]	-RRB-
cord-019001-ralxw4ad	213	46	.	.	.
cord-019001-ralxw4ad	214	1	In	in	IN
cord-019001-ralxw4ad	214	2	patients	patient	NNS
cord-019001-ralxw4ad	214	3	with	with	IN
cord-019001-ralxw4ad	214	4	refractory	refractory	JJ
cord-019001-ralxw4ad	214	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	214	6	hypertension	hypertension	NN
cord-019001-ralxw4ad	214	7	,	,	,
cord-019001-ralxw4ad	214	8	short	short	JJ
cord-019001-ralxw4ad	214	9	-	-	HYPH
cord-019001-ralxw4ad	214	10	term	term	NN
cord-019001-ralxw4ad	214	11	postoperative	postoperative	JJ
cord-019001-ralxw4ad	214	12	extracorporeal	extracorporeal	NN
cord-019001-ralxw4ad	214	13	support	support	NN
cord-019001-ralxw4ad	214	14	has	have	VBZ
cord-019001-ralxw4ad	214	15	been	be	VBN
cord-019001-ralxw4ad	214	16	useful	useful	JJ
cord-019001-ralxw4ad	214	17	during	during	IN
cord-019001-ralxw4ad	214	18	the	the	DT
cord-019001-ralxw4ad	214	19	postoperative	postoperative	JJ
cord-019001-ralxw4ad	214	20	period	period	NN
cord-019001-ralxw4ad	214	21	of	of	IN
cord-019001-ralxw4ad	214	22	extreme	extreme	JJ
cord-019001-ralxw4ad	214	23	vasoreactivity	vasoreactivity	NN
cord-019001-ralxw4ad	214	24	.	.	.
cord-019001-ralxw4ad	215	1	However	however	RB
cord-019001-ralxw4ad	215	2	,	,	,
cord-019001-ralxw4ad	215	3	its	-PRON-	PRP$
cord-019001-ralxw4ad	215	4	use	use	NN
cord-019001-ralxw4ad	215	5	should	should	MD
cord-019001-ralxw4ad	215	6	be	be	VB
cord-019001-ralxw4ad	215	7	limited	limit	VBN
cord-019001-ralxw4ad	215	8	to	to	TO
cord-019001-ralxw4ad	215	9	support	support	VB
cord-019001-ralxw4ad	215	10	those	those	DT
cord-019001-ralxw4ad	215	11	patients	patient	NNS
cord-019001-ralxw4ad	215	12	in	in	IN
cord-019001-ralxw4ad	215	13	which	which	WDT
cord-019001-ralxw4ad	215	14	the	the	DT
cord-019001-ralxw4ad	215	15	underlying	underlying	JJ
cord-019001-ralxw4ad	215	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	215	17	vascular	vascular	JJ
cord-019001-ralxw4ad	215	18	disease	disease	NN
cord-019001-ralxw4ad	215	19	is	be	VBZ
cord-019001-ralxw4ad	215	20	deemed	deem	VBN
cord-019001-ralxw4ad	215	21	reversible	reversible	JJ
cord-019001-ralxw4ad	215	22	.	.	.
cord-019001-ralxw4ad	216	1	Whenever	whenever	WRB
cord-019001-ralxw4ad	216	2	possible	possible	JJ
cord-019001-ralxw4ad	216	3	,	,	,
cord-019001-ralxw4ad	216	4	treatment	treatment	NN
cord-019001-ralxw4ad	216	5	of	of	IN
cord-019001-ralxw4ad	216	6	the	the	DT
cord-019001-ralxw4ad	216	7	underlying	underlying	JJ
cord-019001-ralxw4ad	216	8	disorder	disorder	NN
cord-019001-ralxw4ad	216	9	must	must	MD
cord-019001-ralxw4ad	216	10	coincide	coincide	VB
cord-019001-ralxw4ad	216	11	with	with	IN
cord-019001-ralxw4ad	216	12	symptomatic	symptomatic	JJ
cord-019001-ralxw4ad	216	13	treatment	treatment	NN
cord-019001-ralxw4ad	216	14	for	for	IN
cord-019001-ralxw4ad	216	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	216	16	hypertension	hypertension	NN
cord-019001-ralxw4ad	216	17	if	if	IN
cord-019001-ralxw4ad	216	18	attenuation	attenuation	NN
cord-019001-ralxw4ad	216	19	and/	and/	CD
cord-019001-ralxw4ad	216	20	reversal	reversal	NN
cord-019001-ralxw4ad	216	21	of	of	IN
cord-019001-ralxw4ad	216	22	the	the	DT
cord-019001-ralxw4ad	216	23	disease	disease	NN
cord-019001-ralxw4ad	216	24	are	be	VBP
cord-019001-ralxw4ad	216	25	to	to	TO
cord-019001-ralxw4ad	216	26	be	be	VB
cord-019001-ralxw4ad	216	27	successful	successful	JJ
cord-019001-ralxw4ad	216	28	.	.	.
cord-019001-ralxw4ad	217	1	For	for	IN
cord-019001-ralxw4ad	217	2	example	example	NN
cord-019001-ralxw4ad	217	3	,	,	,
cord-019001-ralxw4ad	217	4	in	in	IN
cord-019001-ralxw4ad	217	5	neonates	neonate	NNS
cord-019001-ralxw4ad	217	6	,	,	,
cord-019001-ralxw4ad	217	7	this	this	DT
cord-019001-ralxw4ad	217	8	may	may	MD
cord-019001-ralxw4ad	217	9	involve	involve	VB
cord-019001-ralxw4ad	217	10	correction	correction	NN
cord-019001-ralxw4ad	217	11	of	of	IN
cord-019001-ralxw4ad	217	12	underlying	underlie	VBG
cord-019001-ralxw4ad	217	13	metabolic	metabolic	JJ
cord-019001-ralxw4ad	217	14	disturbances	disturbance	NNS
cord-019001-ralxw4ad	217	15	,	,	,
cord-019001-ralxw4ad	217	16	antibiotics	antibiotic	NNS
cord-019001-ralxw4ad	217	17	for	for	IN
cord-019001-ralxw4ad	217	18	infectious	infectious	JJ
cord-019001-ralxw4ad	217	19	etiologies	etiology	NNS
cord-019001-ralxw4ad	217	20	,	,	,
cord-019001-ralxw4ad	217	21	and	and	CC
cord-019001-ralxw4ad	217	22	exchange	exchange	NN
cord-019001-ralxw4ad	217	23	transfusions	transfusion	NNS
cord-019001-ralxw4ad	217	24	for	for	IN
cord-019001-ralxw4ad	217	25	polycythemia	polycythemia	NN
cord-019001-ralxw4ad	217	26	.	.	.
cord-019001-ralxw4ad	218	1	For	for	IN
cord-019001-ralxw4ad	218	2	patients	patient	NNS
cord-019001-ralxw4ad	218	3	with	with	IN
cord-019001-ralxw4ad	218	4	congenital	congenital	JJ
cord-019001-ralxw4ad	218	5	heart	heart	NN
cord-019001-ralxw4ad	218	6	disease	disease	NN
cord-019001-ralxw4ad	218	7	,	,	,
cord-019001-ralxw4ad	218	8	repair	repair	NN
cord-019001-ralxw4ad	218	9	of	of	IN
cord-019001-ralxw4ad	218	10	the	the	DT
cord-019001-ralxw4ad	218	11	underlying	underlying	JJ
cord-019001-ralxw4ad	218	12	defect	defect	NN
cord-019001-ralxw4ad	218	13	,	,	,
cord-019001-ralxw4ad	218	14	after	after	IN
cord-019001-ralxw4ad	218	15	determining	determine	VBG
cord-019001-ralxw4ad	218	16	that	that	IN
cord-019001-ralxw4ad	218	17	the	the	DT
cord-019001-ralxw4ad	218	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	218	19	vascular	vascular	JJ
cord-019001-ralxw4ad	218	20	disease	disease	NN
cord-019001-ralxw4ad	218	21	is	be	VBZ
cord-019001-ralxw4ad	218	22	reversible	reversible	JJ
cord-019001-ralxw4ad	218	23	(	(	-LRB-
cord-019001-ralxw4ad	218	24	see	see	VB
cord-019001-ralxw4ad	218	25	later	later	RBR
cord-019001-ralxw4ad	218	26	)	)	-RRB-
cord-019001-ralxw4ad	218	27	,	,	,
cord-019001-ralxw4ad	218	28	is	be	VBZ
cord-019001-ralxw4ad	218	29	mandatory	mandatory	JJ
cord-019001-ralxw4ad	218	30	.	.	.
cord-019001-ralxw4ad	219	1	For	for	IN
cord-019001-ralxw4ad	219	2	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	219	3	-	-	HYPH
cord-019001-ralxw4ad	219	4	induced	induce	VBN
cord-019001-ralxw4ad	219	5	disease	disease	NN
cord-019001-ralxw4ad	219	6	,	,	,
cord-019001-ralxw4ad	219	7	tonsillectomy	tonsillectomy	NN
cord-019001-ralxw4ad	219	8	and	and	CC
cord-019001-ralxw4ad	219	9	adenoidectomy	adenoidectomy	NN
cord-019001-ralxw4ad	219	10	may	may	MD
cord-019001-ralxw4ad	219	11	be	be	VB
cord-019001-ralxw4ad	219	12	required	require	VBN
cord-019001-ralxw4ad	219	13	for	for	IN
cord-019001-ralxw4ad	219	14	sleep	sleep	NN
cord-019001-ralxw4ad	219	15	apnea	apnea	NN
cord-019001-ralxw4ad	219	16	,	,	,
cord-019001-ralxw4ad	219	17	and	and	CC
cord-019001-ralxw4ad	219	18	a	a	DT
cord-019001-ralxw4ad	219	19	descent	descent	NN
cord-019001-ralxw4ad	219	20	to	to	IN
cord-019001-ralxw4ad	219	21	sea	sea	NN
cord-019001-ralxw4ad	219	22	level	level	NN
cord-019001-ralxw4ad	219	23	may	may	MD
cord-019001-ralxw4ad	219	24	be	be	VB
cord-019001-ralxw4ad	219	25	needed	need	VBN
cord-019001-ralxw4ad	219	26	for	for	IN
cord-019001-ralxw4ad	219	27	high	high	JJ
cord-019001-ralxw4ad	219	28	-	-	HYPH
cord-019001-ralxw4ad	219	29	altitude	altitude	NN
cord-019001-ralxw4ad	219	30	-	-	HYPH
cord-019001-ralxw4ad	219	31	related	relate	VBN
cord-019001-ralxw4ad	219	32	disease	disease	NN
cord-019001-ralxw4ad	219	33	.	.	.
cord-019001-ralxw4ad	220	1	Finally	finally	RB
cord-019001-ralxw4ad	220	2	,	,	,
cord-019001-ralxw4ad	220	3	for	for	IN
cord-019001-ralxw4ad	220	4	rheumatologic	rheumatologic	JJ
cord-019001-ralxw4ad	220	5	disease	disease	NN
cord-019001-ralxw4ad	220	6	,	,	,
cord-019001-ralxw4ad	220	7	immunosuppression	immunosuppression	NN
cord-019001-ralxw4ad	220	8	may	may	MD
cord-019001-ralxw4ad	220	9	be	be	VB
cord-019001-ralxw4ad	220	10	required	require	VBN
cord-019001-ralxw4ad	220	11	.	.	.
cord-019001-ralxw4ad	221	1	The	the	DT
cord-019001-ralxw4ad	221	2	mainstay	mainstay	NN
cord-019001-ralxw4ad	221	3	of	of	IN
cord-019001-ralxw4ad	221	4	chronic	chronic	JJ
cord-019001-ralxw4ad	221	5	therapy	therapy	NN
cord-019001-ralxw4ad	221	6	has	have	VBZ
cord-019001-ralxw4ad	221	7	been	be	VBN
cord-019001-ralxw4ad	221	8	aimed	aim	VBN
cord-019001-ralxw4ad	221	9	at	at	IN
cord-019001-ralxw4ad	221	10	decreasing	decrease	VBG
cord-019001-ralxw4ad	221	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	221	12	vascular	vascular	JJ
cord-019001-ralxw4ad	221	13	resistance	resistance	NN
cord-019001-ralxw4ad	221	14	,	,	,
cord-019001-ralxw4ad	221	15	thereby	thereby	RB
cord-019001-ralxw4ad	221	16	assisting	assist	VBG
cord-019001-ralxw4ad	221	17	right	right	JJ
cord-019001-ralxw4ad	221	18	ventricular	ventricular	JJ
cord-019001-ralxw4ad	221	19	function	function	NN
cord-019001-ralxw4ad	221	20	and	and	CC
cord-019001-ralxw4ad	221	21	perhaps	perhaps	RB
cord-019001-ralxw4ad	221	22	attenuating	attenuate	VBG
cord-019001-ralxw4ad	221	23	the	the	DT
cord-019001-ralxw4ad	221	24	progression	progression	NN
cord-019001-ralxw4ad	221	25	of	of	IN
cord-019001-ralxw4ad	221	26	vascular	vascular	JJ
cord-019001-ralxw4ad	221	27	remodeling	remodeling	NN
cord-019001-ralxw4ad	221	28	by	by	IN
cord-019001-ralxw4ad	221	29	decreasing	decrease	VBG
cord-019001-ralxw4ad	221	30	the	the	DT
cord-019001-ralxw4ad	221	31	pressure	pressure	NN
cord-019001-ralxw4ad	221	32	to	to	TO
cord-019001-ralxw4ad	221	33	which	which	WDT
cord-019001-ralxw4ad	221	34	the	the	DT
cord-019001-ralxw4ad	221	35	vasculature	vasculature	NN
cord-019001-ralxw4ad	221	36	is	be	VBZ
cord-019001-ralxw4ad	221	37	exposed	expose	VBN
cord-019001-ralxw4ad	221	38	.	.	.
cord-019001-ralxw4ad	222	1	The	the	DT
cord-019001-ralxw4ad	222	2	continuous	continuous	JJ
cord-019001-ralxw4ad	222	3	infusion	infusion	NN
cord-019001-ralxw4ad	222	4	of	of	IN
cord-019001-ralxw4ad	222	5	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	222	6	(	(	-LRB-
cord-019001-ralxw4ad	222	7	epoprostin	epoprostin	NNP
cord-019001-ralxw4ad	222	8	)	)	-RRB-
cord-019001-ralxw4ad	222	9	has	have	VBZ
cord-019001-ralxw4ad	222	10	been	be	VBN
cord-019001-ralxw4ad	222	11	the	the	DT
cord-019001-ralxw4ad	222	12	most	most	RBS
cord-019001-ralxw4ad	222	13	successful	successful	JJ
cord-019001-ralxw4ad	222	14	therapy	therapy	NN
cord-019001-ralxw4ad	222	15	to	to	IN
cord-019001-ralxw4ad	222	16	date	date	NN
cord-019001-ralxw4ad	222	17	in	in	IN
cord-019001-ralxw4ad	222	18	this	this	DT
cord-019001-ralxw4ad	222	19	regard	regard	NN
cord-019001-ralxw4ad	222	20	[	[	-LRB-
cord-019001-ralxw4ad	222	21	181	181	CD
cord-019001-ralxw4ad	222	22	]	]	-RRB-
cord-019001-ralxw4ad	222	23	[	[	-LRB-
cord-019001-ralxw4ad	222	24	182	182	CD
cord-019001-ralxw4ad	222	25	]	]	-RRB-
cord-019001-ralxw4ad	222	26	[	[	-LRB-
cord-019001-ralxw4ad	222	27	183	183	CD
cord-019001-ralxw4ad	222	28	]	]	-RRB-
cord-019001-ralxw4ad	222	29	[	[	-LRB-
cord-019001-ralxw4ad	222	30	184	184	CD
cord-019001-ralxw4ad	222	31	]	]	-RRB-
cord-019001-ralxw4ad	222	32	[	[	-LRB-
cord-019001-ralxw4ad	222	33	185	185	CD
cord-019001-ralxw4ad	222	34	]	]	-RRB-
cord-019001-ralxw4ad	222	35	.	.	.
cord-019001-ralxw4ad	223	1	In	in	IN
cord-019001-ralxw4ad	223	2	fact	fact	NN
cord-019001-ralxw4ad	223	3	,	,	,
cord-019001-ralxw4ad	223	4	several	several	JJ
cord-019001-ralxw4ad	223	5	studies	study	NNS
cord-019001-ralxw4ad	223	6	in	in	IN
cord-019001-ralxw4ad	223	7	humans	human	NNS
cord-019001-ralxw4ad	223	8	with	with	IN
cord-019001-ralxw4ad	223	9	advanced	advanced	JJ
cord-019001-ralxw4ad	223	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	223	11	vascular	vascular	JJ
cord-019001-ralxw4ad	223	12	disease	disease	NN
cord-019001-ralxw4ad	223	13	demonstrate	demonstrate	VBP
cord-019001-ralxw4ad	223	14	improved	improve	VBN
cord-019001-ralxw4ad	223	15	5-year	5-year	CD
cord-019001-ralxw4ad	223	16	survival	survival	NN
cord-019001-ralxw4ad	223	17	and	and	CC
cord-019001-ralxw4ad	223	18	improved	improved	JJ
cord-019001-ralxw4ad	223	19	exercise	exercise	NN
cord-019001-ralxw4ad	223	20	tolerance	tolerance	NN
cord-019001-ralxw4ad	223	21	.	.	.
cord-019001-ralxw4ad	224	1	Interestingly	interestingly	RB
cord-019001-ralxw4ad	224	2	,	,	,
cord-019001-ralxw4ad	224	3	even	even	RB
cord-019001-ralxw4ad	224	4	those	those	DT
cord-019001-ralxw4ad	224	5	patients	patient	NNS
cord-019001-ralxw4ad	224	6	without	without	IN
cord-019001-ralxw4ad	224	7	an	an	DT
cord-019001-ralxw4ad	224	8	initial	initial	JJ
cord-019001-ralxw4ad	224	9	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	224	10	response	response	NN
cord-019001-ralxw4ad	224	11	to	to	IN
cord-019001-ralxw4ad	224	12	the	the	DT
cord-019001-ralxw4ad	224	13	infusion	infusion	NN
cord-019001-ralxw4ad	224	14	show	show	NN
cord-019001-ralxw4ad	224	15	signifi	signifi	NNP
cord-019001-ralxw4ad	224	16	ca	can	MD
cord-019001-ralxw4ad	224	17	nt	not	RB
cord-019001-ralxw4ad	224	18	longterm	longterm	JJ
cord-019001-ralxw4ad	224	19	benefi	benefi	NNP
cord-019001-ralxw4ad	224	20	t	t	NNP
cord-019001-ralxw4ad	224	21	,	,	,
cord-019001-ralxw4ad	224	22	suggesting	suggest	VBG
cord-019001-ralxw4ad	224	23	that	that	IN
cord-019001-ralxw4ad	224	24	effects	effect	NNS
cord-019001-ralxw4ad	224	25	beyond	beyond	IN
cord-019001-ralxw4ad	224	26	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	224	27	,	,	,
cord-019001-ralxw4ad	224	28	such	such	JJ
cord-019001-ralxw4ad	224	29	as	as	IN
cord-019001-ralxw4ad	224	30	antiplatelet	antiplatelet	JJ
cord-019001-ralxw4ad	224	31	effects	effect	NNS
cord-019001-ralxw4ad	224	32	,	,	,
cord-019001-ralxw4ad	224	33	cAMP	camp	NN
cord-019001-ralxw4ad	224	34	-	-	HYPH
cord-019001-ralxw4ad	224	35	mediated	mediate	VBN
cord-019001-ralxw4ad	224	36	inhibition	inhibition	NN
cord-019001-ralxw4ad	224	37	of	of	IN
cord-019001-ralxw4ad	224	38	smooth	smooth	JJ
cord-019001-ralxw4ad	224	39	muscle	muscle	NN
cord-019001-ralxw4ad	224	40	cell	cell	NN
cord-019001-ralxw4ad	224	41	growth	growth	NN
cord-019001-ralxw4ad	224	42	,	,	,
cord-019001-ralxw4ad	224	43	or	or	CC
cord-019001-ralxw4ad	224	44	other	other	JJ
cord-019001-ralxw4ad	224	45	unknown	unknown	JJ
cord-019001-ralxw4ad	224	46	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	224	47	may	may	MD
cord-019001-ralxw4ad	224	48	be	be	VB
cord-019001-ralxw4ad	224	49	responsible	responsible	JJ
cord-019001-ralxw4ad	224	50	for	for	IN
cord-019001-ralxw4ad	224	51	the	the	DT
cord-019001-ralxw4ad	224	52	treatment	treatment	NN
cord-019001-ralxw4ad	224	53	effect	effect	NN
cord-019001-ralxw4ad	224	54	[	[	-LRB-
cord-019001-ralxw4ad	224	55	186	186	CD
cord-019001-ralxw4ad	224	56	]	]	-RRB-
cord-019001-ralxw4ad	224	57	.	.	.
cord-019001-ralxw4ad	225	1	Despite	despite	IN
cord-019001-ralxw4ad	225	2	the	the	DT
cord-019001-ralxw4ad	225	3	impressive	impressive	JJ
cord-019001-ralxw4ad	225	4	results	result	NNS
cord-019001-ralxw4ad	225	5	,	,	,
cord-019001-ralxw4ad	225	6	several	several	JJ
cord-019001-ralxw4ad	225	7	factors	factor	NNS
cord-019001-ralxw4ad	225	8	limit	limit	VBP
cord-019001-ralxw4ad	225	9	its	-PRON-	PRP$
cord-019001-ralxw4ad	225	10	utilization	utilization	NN
cord-019001-ralxw4ad	225	11	,	,	,
cord-019001-ralxw4ad	225	12	including	include	VBG
cord-019001-ralxw4ad	225	13	the	the	DT
cord-019001-ralxw4ad	225	14	need	need	NN
cord-019001-ralxw4ad	225	15	for	for	IN
cord-019001-ralxw4ad	225	16	chronic	chronic	JJ
cord-019001-ralxw4ad	225	17	intravascular	intravascular	JJ
cord-019001-ralxw4ad	225	18	assess	assess	NN
cord-019001-ralxw4ad	225	19	with	with	IN
cord-019001-ralxw4ad	225	20	the	the	DT
cord-019001-ralxw4ad	225	21	associated	associate	VBN
cord-019001-ralxw4ad	225	22	infectious	infectious	JJ
cord-019001-ralxw4ad	225	23	and	and	CC
cord-019001-ralxw4ad	225	24	thrombotic	thrombotic	JJ
cord-019001-ralxw4ad	225	25	risks	risk	NNS
cord-019001-ralxw4ad	225	26	,	,	,
cord-019001-ralxw4ad	225	27	and	and	CC
cord-019001-ralxw4ad	225	28	many	many	JJ
cord-019001-ralxw4ad	225	29	other	other	JJ
cord-019001-ralxw4ad	225	30	untoward	untoward	JJ
cord-019001-ralxw4ad	225	31	effects	effect	NNS
cord-019001-ralxw4ad	225	32	,	,	,
cord-019001-ralxw4ad	225	33	including	include	VBG
cord-019001-ralxw4ad	225	34	headache	headache	NN
cord-019001-ralxw4ad	225	35	,	,	,
cord-019001-ralxw4ad	225	36	fl	fl	NNP
cord-019001-ralxw4ad	225	37	ushing	ushing	NN
cord-019001-ralxw4ad	225	38	,	,	,
cord-019001-ralxw4ad	225	39	and	and	CC
cord-019001-ralxw4ad	225	40	acute	acute	JJ
cord-019001-ralxw4ad	225	41	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	225	42	compromise	compromise	NN
cord-019001-ralxw4ad	225	43	with	with	IN
cord-019001-ralxw4ad	225	44	disruption	disruption	NN
cord-019001-ralxw4ad	225	45	of	of	IN
cord-019001-ralxw4ad	225	46	the	the	DT
cord-019001-ralxw4ad	225	47	infusion	infusion	NN
cord-019001-ralxw4ad	225	48	[	[	-LRB-
cord-019001-ralxw4ad	225	49	187	187	CD
cord-019001-ralxw4ad	225	50	]	]	-RRB-
cord-019001-ralxw4ad	225	51	.	.	.
cord-019001-ralxw4ad	226	1	With	with	IN
cord-019001-ralxw4ad	226	2	the	the	DT
cord-019001-ralxw4ad	226	3	increasing	increase	VBG
cord-019001-ralxw4ad	226	4	appreciation	appreciation	NN
cord-019001-ralxw4ad	226	5	for	for	IN
cord-019001-ralxw4ad	226	6	the	the	DT
cord-019001-ralxw4ad	226	7	role	role	NN
cord-019001-ralxw4ad	226	8	of	of	IN
cord-019001-ralxw4ad	226	9	ET-1	ET-1	NNP
cord-019001-ralxw4ad	226	10	in	in	IN
cord-019001-ralxw4ad	226	11	the	the	DT
cord-019001-ralxw4ad	226	12	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	226	13	of	of	IN
cord-019001-ralxw4ad	226	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	226	15	vascular	vascular	JJ
cord-019001-ralxw4ad	226	16	disease	disease	NN
cord-019001-ralxw4ad	226	17	,	,	,
cord-019001-ralxw4ad	226	18	ET	ET	NNP
cord-019001-ralxw4ad	226	19	receptor	receptor	NN
cord-019001-ralxw4ad	226	20	antagonists	antagonist	NNS
cord-019001-ralxw4ad	226	21	have	have	VBP
cord-019001-ralxw4ad	226	22	been	be	VBN
cord-019001-ralxw4ad	226	23	developed	develop	VBN
cord-019001-ralxw4ad	226	24	as	as	IN
cord-019001-ralxw4ad	226	25	a	a	DT
cord-019001-ralxw4ad	226	26	potential	potential	JJ
cord-019001-ralxw4ad	226	27	treatment	treatment	NN
cord-019001-ralxw4ad	226	28	modality	modality	NN
cord-019001-ralxw4ad	226	29	.	.	.
cord-019001-ralxw4ad	227	1	To	to	IN
cord-019001-ralxw4ad	227	2	date	date	NN
cord-019001-ralxw4ad	227	3	,	,	,
cord-019001-ralxw4ad	227	4	bosentan	bosentan	NNP
cord-019001-ralxw4ad	227	5	,	,	,
cord-019001-ralxw4ad	227	6	a	a	DT
cord-019001-ralxw4ad	227	7	combined	combine	VBN
cord-019001-ralxw4ad	227	8	ET	ET	NNP
cord-019001-ralxw4ad	227	9	A	a	NN
cord-019001-ralxw4ad	227	10	and	and	CC
cord-019001-ralxw4ad	227	11	ET	ET	NNP
cord-019001-ralxw4ad	227	12	B	B	NNP
cord-019001-ralxw4ad	227	13	receptor	receptor	NN
cord-019001-ralxw4ad	227	14	antagonist	antagonist	NN
cord-019001-ralxw4ad	227	15	,	,	,
cord-019001-ralxw4ad	227	16	is	be	VBZ
cord-019001-ralxw4ad	227	17	the	the	DT
cord-019001-ralxw4ad	227	18	most	most	RBS
cord-019001-ralxw4ad	227	19	widely	widely	RB
cord-019001-ralxw4ad	227	20	studied	study	VBN
cord-019001-ralxw4ad	227	21	agent	agent	NN
cord-019001-ralxw4ad	227	22	and	and	CC
cord-019001-ralxw4ad	227	23	is	be	VBZ
cord-019001-ralxw4ad	227	24	the	the	DT
cord-019001-ralxw4ad	227	25	only	only	JJ
cord-019001-ralxw4ad	227	26	receptor	receptor	NN
cord-019001-ralxw4ad	227	27	antagonist	antagonist	NN
cord-019001-ralxw4ad	227	28	approved	approve	VBN
cord-019001-ralxw4ad	227	29	for	for	IN
cord-019001-ralxw4ad	227	30	the	the	DT
cord-019001-ralxw4ad	227	31	treatment	treatment	NN
cord-019001-ralxw4ad	227	32	of	of	IN
cord-019001-ralxw4ad	227	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	227	34	hypertension	hypertension	NN
cord-019001-ralxw4ad	227	35	[	[	-LRB-
cord-019001-ralxw4ad	227	36	167	167	CD
cord-019001-ralxw4ad	227	37	,	,	,
cord-019001-ralxw4ad	227	38	168	168	CD
cord-019001-ralxw4ad	227	39	]	]	-RRB-
cord-019001-ralxw4ad	227	40	.	.	.
cord-019001-ralxw4ad	228	1	Recent	recent	JJ
cord-019001-ralxw4ad	228	2	studies	study	NNS
cord-019001-ralxw4ad	228	3	in	in	IN
cord-019001-ralxw4ad	228	4	adults	adult	NNS
cord-019001-ralxw4ad	228	5	with	with	IN
cord-019001-ralxw4ad	228	6	primary	primary	JJ
cord-019001-ralxw4ad	228	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	228	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	228	9	demonstrate	demonstrate	VBP
cord-019001-ralxw4ad	228	10	similar	similar	JJ
cord-019001-ralxw4ad	228	11	improvements	improvement	NNS
cord-019001-ralxw4ad	228	12	in	in	IN
cord-019001-ralxw4ad	228	13	survival	survival	NN
cord-019001-ralxw4ad	228	14	and	and	CC
cord-019001-ralxw4ad	228	15	exercise	exercise	VB
cord-019001-ralxw4ad	228	16	tolerance	tolerance	NN
cord-019001-ralxw4ad	228	17	as	as	IN
cord-019001-ralxw4ad	228	18	those	those	DT
cord-019001-ralxw4ad	228	19	demonstrated	demonstrate	VBN
cord-019001-ralxw4ad	228	20	with	with	IN
cord-019001-ralxw4ad	228	21	epoprostenol	epoprostenol	NNP
cord-019001-ralxw4ad	228	22	[	[	-LRB-
cord-019001-ralxw4ad	228	23	188	188	CD
cord-019001-ralxw4ad	228	24	]	]	-RRB-
cord-019001-ralxw4ad	228	25	.	.	.
cord-019001-ralxw4ad	229	1	The	the	DT
cord-019001-ralxw4ad	229	2	use	use	NN
cord-019001-ralxw4ad	229	3	of	of	IN
cord-019001-ralxw4ad	229	4	ET	ET	NNP
cord-019001-ralxw4ad	229	5	receptor	receptor	NN
cord-019001-ralxw4ad	229	6	antagonists	antagonist	NNS
cord-019001-ralxw4ad	229	7	for	for	IN
cord-019001-ralxw4ad	229	8	pediatric	pediatric	JJ
cord-019001-ralxw4ad	229	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	229	10	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	229	11	disorders	disorder	NNS
cord-019001-ralxw4ad	229	12	is	be	VBZ
cord-019001-ralxw4ad	229	13	currently	currently	RB
cord-019001-ralxw4ad	229	14	under	under	IN
cord-019001-ralxw4ad	229	15	investigation	investigation	NN
cord-019001-ralxw4ad	229	16	.	.	.
cord-019001-ralxw4ad	230	1	Defi	Defi	NNP
cord-019001-ralxw4ad	230	2	ciencies	ciencie	NNS
cord-019001-ralxw4ad	230	3	in	in	IN
cord-019001-ralxw4ad	230	4	the	the	DT
cord-019001-ralxw4ad	230	5	NO	no	JJ
cord-019001-ralxw4ad	230	6	-	-	HYPH
cord-019001-ralxw4ad	230	7	cGMP	cgmp	JJ
cord-019001-ralxw4ad	230	8	cascade	cascade	NN
cord-019001-ralxw4ad	230	9	in	in	IN
cord-019001-ralxw4ad	230	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	230	11	vascular	vascular	JJ
cord-019001-ralxw4ad	230	12	disease	disease	NN
cord-019001-ralxw4ad	230	13	are	be	VBP
cord-019001-ralxw4ad	230	14	well	well	RB
cord-019001-ralxw4ad	230	15	documented	document	VBN
cord-019001-ralxw4ad	230	16	.	.	.
cord-019001-ralxw4ad	231	1	In	in	IN
cord-019001-ralxw4ad	231	2	addition	addition	NN
cord-019001-ralxw4ad	231	3	,	,	,
cord-019001-ralxw4ad	231	4	the	the	DT
cord-019001-ralxw4ad	231	5	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	231	6	effects	effect	NNS
cord-019001-ralxw4ad	231	7	,	,	,
cord-019001-ralxw4ad	231	8	antiplatelet	antiplatelet	JJ
cord-019001-ralxw4ad	231	9	effects	effect	NNS
cord-019001-ralxw4ad	231	10	,	,	,
cord-019001-ralxw4ad	231	11	and	and	CC
cord-019001-ralxw4ad	231	12	antiproliferative	antiproliferative	JJ
cord-019001-ralxw4ad	231	13	effects	effect	NNS
cord-019001-ralxw4ad	231	14	of	of	IN
cord-019001-ralxw4ad	231	15	augmenting	augment	VBG
cord-019001-ralxw4ad	231	16	this	this	DT
cord-019001-ralxw4ad	231	17	cascade	cascade	NN
cord-019001-ralxw4ad	231	18	are	be	VBP
cord-019001-ralxw4ad	231	19	well	well	RB
cord-019001-ralxw4ad	231	20	appreciated	appreciate	VBN
cord-019001-ralxw4ad	231	21	.	.	.
cord-019001-ralxw4ad	232	1	Therefore	therefore	RB
cord-019001-ralxw4ad	232	2	,	,	,
cord-019001-ralxw4ad	232	3	new	new	JJ
cord-019001-ralxw4ad	232	4	chronic	chronic	JJ
cord-019001-ralxw4ad	232	5	therapies	therapy	NNS
cord-019001-ralxw4ad	232	6	that	that	WDT
cord-019001-ralxw4ad	232	7	augment	augment	VBP
cord-019001-ralxw4ad	232	8	NO	NO	NNP
cord-019001-ralxw4ad	232	9	-	-	HYPH
cord-019001-ralxw4ad	232	10	cGMP	cgmp	JJ
cord-019001-ralxw4ad	232	11	signaling	signaling	NN
cord-019001-ralxw4ad	232	12	,	,	,
cord-019001-ralxw4ad	232	13	which	which	WDT
cord-019001-ralxw4ad	232	14	include	include	VBP
cord-019001-ralxw4ad	232	15	chronic	chronic	NN
cord-019001-ralxw4ad	232	16	inhaled	inhale	VBN
cord-019001-ralxw4ad	232	17	NO	no	DT
cord-019001-ralxw4ad	232	18	delivered	deliver	VBN
cord-019001-ralxw4ad	232	19	by	by	IN
cord-019001-ralxw4ad	232	20	nasal	nasal	NN
cord-019001-ralxw4ad	232	21	cannula	cannula	NN
cord-019001-ralxw4ad	232	22	and	and	CC
cord-019001-ralxw4ad	232	23	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	232	24	l	l	NNP
cord-019001-ralxw4ad	232	25	,	,	,
cord-019001-ralxw4ad	232	26	are	be	VBP
cord-019001-ralxw4ad	232	27	currently	currently	RB
cord-019001-ralxw4ad	232	28	under	under	IN
cord-019001-ralxw4ad	232	29	investigation	investigation	NN
cord-019001-ralxw4ad	232	30	[	[	-LRB-
cord-019001-ralxw4ad	232	31	187	187	CD
cord-019001-ralxw4ad	232	32	]	]	-RRB-
cord-019001-ralxw4ad	232	33	.	.	.
cord-019001-ralxw4ad	233	1	In	in	IN
cord-019001-ralxw4ad	233	2	fact	fact	NN
cord-019001-ralxw4ad	233	3	,	,	,
cord-019001-ralxw4ad	233	4	the	the	DT
cord-019001-ralxw4ad	233	5	short	short	JJ
cord-019001-ralxw4ad	233	6	-	-	HYPH
cord-019001-ralxw4ad	233	7	term	term	NN
cord-019001-ralxw4ad	233	8	benefi	benefi	NNP
cord-019001-ralxw4ad	233	9	t	t	NNP
cord-019001-ralxw4ad	233	10	of	of	IN
cord-019001-ralxw4ad	233	11	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	233	12	l	l	NNP
cord-019001-ralxw4ad	233	13	in	in	IN
cord-019001-ralxw4ad	233	14	children	child	NNS
cord-019001-ralxw4ad	233	15	with	with	IN
cord-019001-ralxw4ad	233	16	advanced	advanced	JJ
cord-019001-ralxw4ad	233	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	233	18	hypertension	hypertension	NN
cord-019001-ralxw4ad	233	19	has	have	VBZ
cord-019001-ralxw4ad	233	20	recently	recently	RB
cord-019001-ralxw4ad	233	21	been	be	VBN
cord-019001-ralxw4ad	233	22	reported	report	VBN
cord-019001-ralxw4ad	233	23	[	[	-LRB-
cord-019001-ralxw4ad	233	24	164	164	CD
cord-019001-ralxw4ad	233	25	]	]	-RRB-
cord-019001-ralxw4ad	233	26	.	.	.
cord-019001-ralxw4ad	234	1	Data	datum	NNS
cord-019001-ralxw4ad	234	2	indicate	indicate	VBP
cord-019001-ralxw4ad	234	3	that	that	IN
cord-019001-ralxw4ad	234	4	several	several	JJ
cord-019001-ralxw4ad	234	5	of	of	IN
cord-019001-ralxw4ad	234	6	these	these	DT
cord-019001-ralxw4ad	234	7	new	new	JJ
cord-019001-ralxw4ad	234	8	oral	oral	JJ
cord-019001-ralxw4ad	234	9	therapies	therapy	NNS
cord-019001-ralxw4ad	234	10	,	,	,
cord-019001-ralxw4ad	234	11	such	such	JJ
cord-019001-ralxw4ad	234	12	as	as	IN
cord-019001-ralxw4ad	234	13	bosentan	bosentan	NNP
cord-019001-ralxw4ad	234	14	and	and	CC
cord-019001-ralxw4ad	234	15	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	234	16	l	l	NNP
cord-019001-ralxw4ad	234	17	,	,	,
cord-019001-ralxw4ad	234	18	may	may	MD
cord-019001-ralxw4ad	234	19	offer	offer	VB
cord-019001-ralxw4ad	234	20	additional	additional	JJ
cord-019001-ralxw4ad	234	21	benefi	benefi	NNP
cord-019001-ralxw4ad	234	22	t	t	NN
cord-019001-ralxw4ad	234	23	by	by	IN
cord-019001-ralxw4ad	234	24	virtue	virtue	NN
cord-019001-ralxw4ad	234	25	of	of	IN
cord-019001-ralxw4ad	234	26	their	-PRON-	PRP$
cord-019001-ralxw4ad	234	27	ability	ability	NN
cord-019001-ralxw4ad	234	28	to	to	TO
cord-019001-ralxw4ad	234	29	inhibit	inhibit	VB
cord-019001-ralxw4ad	234	30	vascular	vascular	JJ
cord-019001-ralxw4ad	234	31	smooth	smooth	JJ
cord-019001-ralxw4ad	234	32	muscle	muscle	NN
cord-019001-ralxw4ad	234	33	growth	growth	NN
cord-019001-ralxw4ad	234	34	and	and	CC
cord-019001-ralxw4ad	234	35	fi	fi	NN
cord-019001-ralxw4ad	234	36	brosis	brosis	NN
cord-019001-ralxw4ad	234	37	[	[	-LRB-
cord-019001-ralxw4ad	234	38	187	187	CD
cord-019001-ralxw4ad	234	39	]	]	-RRB-
cord-019001-ralxw4ad	234	40	.	.	.
cord-019001-ralxw4ad	235	1	A	a	DT
cord-019001-ralxw4ad	235	2	number	number	NN
cord-019001-ralxw4ad	235	3	of	of	IN
cord-019001-ralxw4ad	235	4	other	other	JJ
cord-019001-ralxw4ad	235	5	treatment	treatment	NN
cord-019001-ralxw4ad	235	6	strategies	strategy	NNS
cord-019001-ralxw4ad	235	7	,	,	,
cord-019001-ralxw4ad	235	8	including	include	VBG
cord-019001-ralxw4ad	235	9	combination	combination	NN
cord-019001-ralxw4ad	235	10	drug	drug	NN
cord-019001-ralxw4ad	235	11	therapies	therapy	NNS
cord-019001-ralxw4ad	235	12	,	,	,
cord-019001-ralxw4ad	235	13	are	be	VBP
cord-019001-ralxw4ad	235	14	currently	currently	RB
cord-019001-ralxw4ad	235	15	under	under	IN
cord-019001-ralxw4ad	235	16	investigation	investigation	NN
cord-019001-ralxw4ad	235	17	.	.	.
cord-019001-ralxw4ad	236	1	To	to	IN
cord-019001-ralxw4ad	236	2	date	date	NN
cord-019001-ralxw4ad	236	3	they	-PRON-	PRP
cord-019001-ralxw4ad	236	4	have	have	VBP
cord-019001-ralxw4ad	236	5	been	be	VBN
cord-019001-ralxw4ad	236	6	used	use	VBN
cord-019001-ralxw4ad	236	7	predominantly	predominantly	RB
cord-019001-ralxw4ad	236	8	in	in	IN
cord-019001-ralxw4ad	236	9	advanced	advanced	JJ
cord-019001-ralxw4ad	236	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	236	11	vascular	vascular	JJ
cord-019001-ralxw4ad	236	12	disease	disease	NN
cord-019001-ralxw4ad	236	13	,	,	,
cord-019001-ralxw4ad	236	14	but	but	CC
cord-019001-ralxw4ad	236	15	,	,	,
cord-019001-ralxw4ad	236	16	due	due	IN
cord-019001-ralxw4ad	236	17	to	to	IN
cord-019001-ralxw4ad	236	18	these	these	DT
cord-019001-ralxw4ad	236	19	favorable	favorable	JJ
cord-019001-ralxw4ad	236	20	characteristics	characteristic	NNS
cord-019001-ralxw4ad	236	21	,	,	,
cord-019001-ralxw4ad	236	22	several	several	JJ
cord-019001-ralxw4ad	236	23	potential	potential	JJ
cord-019001-ralxw4ad	236	24	applications	application	NNS
cord-019001-ralxw4ad	236	25	warrant	warrant	VBP
cord-019001-ralxw4ad	236	26	investigation	investigation	NN
cord-019001-ralxw4ad	236	27	.	.	.
cord-019001-ralxw4ad	237	1	This	this	DT
cord-019001-ralxw4ad	237	2	includes	include	VBZ
cord-019001-ralxw4ad	237	3	their	-PRON-	PRP$
cord-019001-ralxw4ad	237	4	use	use	NN
cord-019001-ralxw4ad	237	5	in	in	IN
cord-019001-ralxw4ad	237	6	lung	lung	NN
cord-019001-ralxw4ad	237	7	hypoplastic	hypoplastic	JJ
cord-019001-ralxw4ad	237	8	syndromes	syndrome	NNS
cord-019001-ralxw4ad	237	9	,	,	,
cord-019001-ralxw4ad	237	10	in	in	IN
cord-019001-ralxw4ad	237	11	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	237	12	-	-	HYPH
cord-019001-ralxw4ad	237	13	associated	associate	VBN
cord-019001-ralxw4ad	237	14	disease	disease	NN
cord-019001-ralxw4ad	237	15	,	,	,
cord-019001-ralxw4ad	237	16	and	and	CC
cord-019001-ralxw4ad	237	17	in	in	IN
cord-019001-ralxw4ad	237	18	congenital	congenital	JJ
cord-019001-ralxw4ad	237	19	heart	heart	NN
cord-019001-ralxw4ad	237	20	disease	disease	NN
cord-019001-ralxw4ad	237	21	in	in	IN
cord-019001-ralxw4ad	237	22	order	order	NN
cord-019001-ralxw4ad	237	23	to	to	TO
cord-019001-ralxw4ad	237	24	improve	improve	VB
cord-019001-ralxw4ad	237	25	the	the	DT
cord-019001-ralxw4ad	237	26	operability	operability	NN
cord-019001-ralxw4ad	237	27	of	of	IN
cord-019001-ralxw4ad	237	28	patients	patient	NNS
cord-019001-ralxw4ad	237	29	with	with	IN
cord-019001-ralxw4ad	237	30	modest	modest	JJ
cord-019001-ralxw4ad	237	31	vascular	vascular	JJ
cord-019001-ralxw4ad	237	32	changes	change	NNS
cord-019001-ralxw4ad	237	33	[	[	-LRB-
cord-019001-ralxw4ad	237	34	189	189	CD
cord-019001-ralxw4ad	237	35	]	]	-RRB-
cord-019001-ralxw4ad	237	36	.	.	.
cord-019001-ralxw4ad	238	1	In	in	IN
cord-019001-ralxw4ad	238	2	a	a	DT
cord-019001-ralxw4ad	238	3	number	number	NN
cord-019001-ralxw4ad	238	4	of	of	IN
cord-019001-ralxw4ad	238	5	clinical	clinical	JJ
cord-019001-ralxw4ad	238	6	conditions	condition	NNS
cord-019001-ralxw4ad	238	7	,	,	,
cord-019001-ralxw4ad	238	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	238	9	vascular	vascular	JJ
cord-019001-ralxw4ad	238	10	resistance	resistance	NN
cord-019001-ralxw4ad	238	11	does	do	VBZ
cord-019001-ralxw4ad	238	12	not	not	RB
cord-019001-ralxw4ad	238	13	decrease	decrease	VB
cord-019001-ralxw4ad	238	14	normally	normally	RB
cord-019001-ralxw4ad	238	15	at	at	IN
cord-019001-ralxw4ad	238	16	birth	birth	NN
cord-019001-ralxw4ad	238	17	.	.	.
cord-019001-ralxw4ad	239	1	As	as	IN
cord-019001-ralxw4ad	239	2	a	a	DT
cord-019001-ralxw4ad	239	3	result	result	NN
cord-019001-ralxw4ad	239	4	,	,	,
cord-019001-ralxw4ad	239	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	239	6	blood	blood	NN
cord-019001-ralxw4ad	239	7	fl	fl	NNP
cord-019001-ralxw4ad	239	8	ow	ow	NNP
cord-019001-ralxw4ad	239	9	remains	remain	VBZ
cord-019001-ralxw4ad	239	10	reduced	reduced	JJ
cord-019001-ralxw4ad	239	11	and	and	CC
cord-019001-ralxw4ad	239	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	239	13	arterial	arterial	JJ
cord-019001-ralxw4ad	239	14	pressure	pressure	NN
cord-019001-ralxw4ad	239	15	remains	remain	VBZ
cord-019001-ralxw4ad	239	16	high	high	JJ
cord-019001-ralxw4ad	239	17	.	.	.
cord-019001-ralxw4ad	240	1	The	the	DT
cord-019001-ralxw4ad	240	2	pathophysiologic	pathophysiologic	JJ
cord-019001-ralxw4ad	240	3	effects	effect	NNS
cord-019001-ralxw4ad	240	4	are	be	VBP
cord-019001-ralxw4ad	240	5	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	240	6	,	,	,
cord-019001-ralxw4ad	240	7	myocardial	myocardial	JJ
cord-019001-ralxw4ad	240	8	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	240	9	,	,	,
cord-019001-ralxw4ad	240	10	and	and	CC
cord-019001-ralxw4ad	240	11	a	a	DT
cord-019001-ralxw4ad	240	12	resulting	result	VBG
cord-019001-ralxw4ad	240	13	reduction	reduction	NN
cord-019001-ralxw4ad	240	14	in	in	IN
cord-019001-ralxw4ad	240	15	systemic	systemic	JJ
cord-019001-ralxw4ad	240	16	oxygen	oxygen	NN
cord-019001-ralxw4ad	240	17	delivery	delivery	NN
cord-019001-ralxw4ad	240	18	.	.	.
cord-019001-ralxw4ad	241	1	The	the	DT
cord-019001-ralxw4ad	241	2	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	241	3	is	be	VBZ
cord-019001-ralxw4ad	241	4	most	most	RBS
cord-019001-ralxw4ad	241	5	often	often	RB
cord-019001-ralxw4ad	241	6	secondary	secondary	JJ
cord-019001-ralxw4ad	241	7	to	to	IN
cord-019001-ralxw4ad	241	8	extrapulmonary	extrapulmonary	NNP
cord-019001-ralxw4ad	241	9	rightto	rightto	NNP
cord-019001-ralxw4ad	241	10	-	-	HYPH
cord-019001-ralxw4ad	241	11	left	leave	VBN
cord-019001-ralxw4ad	241	12	shunting	shunting	NN
cord-019001-ralxw4ad	241	13	of	of	IN
cord-019001-ralxw4ad	241	14	blood	blood	NN
cord-019001-ralxw4ad	241	15	at	at	IN
cord-019001-ralxw4ad	241	16	the	the	DT
cord-019001-ralxw4ad	241	17	atrial	atrial	NN
cord-019001-ralxw4ad	241	18	and/or	and/or	CC
cord-019001-ralxw4ad	241	19	ductal	ductal	JJ
cord-019001-ralxw4ad	241	20	levels	level	NNS
cord-019001-ralxw4ad	241	21	but	but	CC
cord-019001-ralxw4ad	241	22	may	may	MD
cord-019001-ralxw4ad	241	23	also	also	RB
cord-019001-ralxw4ad	241	24	be	be	VB
cord-019001-ralxw4ad	241	25	secondary	secondary	JJ
cord-019001-ralxw4ad	241	26	to	to	IN
cord-019001-ralxw4ad	241	27	intrapulmonary	intrapulmonary	JJ
cord-019001-ralxw4ad	241	28	right	right	NN
cord-019001-ralxw4ad	241	29	-	-	HYPH
cord-019001-ralxw4ad	241	30	to	to	IN
cord-019001-ralxw4ad	241	31	-	-	HYPH
cord-019001-ralxw4ad	241	32	left	left	JJ
cord-019001-ralxw4ad	241	33	shunting	shunting	NN
cord-019001-ralxw4ad	241	34	of	of	IN
cord-019001-ralxw4ad	241	35	blood	blood	NN
cord-019001-ralxw4ad	241	36	when	when	WRB
cord-019001-ralxw4ad	241	37	associated	associate	VBN
cord-019001-ralxw4ad	241	38	with	with	IN
cord-019001-ralxw4ad	241	39	parenchymal	parenchymal	JJ
cord-019001-ralxw4ad	241	40	lung	lung	NN
cord-019001-ralxw4ad	241	41	disease	disease	NN
cord-019001-ralxw4ad	241	42	.	.	.
cord-019001-ralxw4ad	242	1	The	the	DT
cord-019001-ralxw4ad	242	2	pathophysiologic	pathophysiologic	NN
cord-019001-ralxw4ad	242	3	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	242	4	preventing	prevent	VBG
cord-019001-ralxw4ad	242	5	the	the	DT
cord-019001-ralxw4ad	242	6	normal	normal	JJ
cord-019001-ralxw4ad	242	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	242	8	vasodilatation	vasodilatation	NN
cord-019001-ralxw4ad	242	9	at	at	IN
cord-019001-ralxw4ad	242	10	birth	birth	NN
cord-019001-ralxw4ad	242	11	remain	remain	VBP
cord-019001-ralxw4ad	242	12	unclear	unclear	JJ
cord-019001-ralxw4ad	242	13	and	and	CC
cord-019001-ralxw4ad	242	14	are	be	VBP
cord-019001-ralxw4ad	242	15	most	most	RBS
cord-019001-ralxw4ad	242	16	likely	likely	RB
cord-019001-ralxw4ad	242	17	multifactorial	multifactorial	JJ
cord-019001-ralxw4ad	242	18	in	in	IN
cord-019001-ralxw4ad	242	19	etiology	etiology	NN
cord-019001-ralxw4ad	242	20	.	.	.
cord-019001-ralxw4ad	243	1	Within	within	IN
cord-019001-ralxw4ad	243	2	this	this	DT
cord-019001-ralxw4ad	243	3	defi	defi	NN
cord-019001-ralxw4ad	243	4	nition	nition	NN
cord-019001-ralxw4ad	243	5	of	of	IN
cord-019001-ralxw4ad	243	6	PPHN	PPHN	NNP
cord-019001-ralxw4ad	243	7	,	,	,
cord-019001-ralxw4ad	243	8	three	three	CD
cord-019001-ralxw4ad	243	9	major	major	JJ
cord-019001-ralxw4ad	243	10	subgroups	subgroup	NNS
cord-019001-ralxw4ad	243	11	are	be	VBP
cord-019001-ralxw4ad	243	12	often	often	RB
cord-019001-ralxw4ad	243	13	characterized	characterize	VBN
cord-019001-ralxw4ad	243	14	:	:	:
cord-019001-ralxw4ad	243	15	those	those	DT
cord-019001-ralxw4ad	243	16	with	with	IN
cord-019001-ralxw4ad	243	17	underdevelopment	underdevelopment	NN
cord-019001-ralxw4ad	243	18	of	of	IN
cord-019001-ralxw4ad	243	19	the	the	DT
cord-019001-ralxw4ad	243	20	lung	lung	NN
cord-019001-ralxw4ad	243	21	,	,	,
cord-019001-ralxw4ad	243	22	those	those	DT
cord-019001-ralxw4ad	243	23	with	with	IN
cord-019001-ralxw4ad	243	24	maladaptation	maladaptation	NN
cord-019001-ralxw4ad	243	25	of	of	IN
cord-019001-ralxw4ad	243	26	the	the	DT
cord-019001-ralxw4ad	243	27	lung	lung	NN
cord-019001-ralxw4ad	243	28	,	,	,
cord-019001-ralxw4ad	243	29	and	and	CC
cord-019001-ralxw4ad	243	30	those	those	DT
cord-019001-ralxw4ad	243	31	with	with	IN
cord-019001-ralxw4ad	243	32	maldevelopment	maldevelopment	NN
cord-019001-ralxw4ad	243	33	of	of	IN
cord-019001-ralxw4ad	243	34	the	the	DT
cord-019001-ralxw4ad	243	35	lung	lung	NN
cord-019001-ralxw4ad	243	36	[	[	-LRB-
cord-019001-ralxw4ad	243	37	58	58	CD
cord-019001-ralxw4ad	243	38	]	]	-RRB-
cord-019001-ralxw4ad	243	39	.	.	.
cord-019001-ralxw4ad	244	1	These	these	DT
cord-019001-ralxw4ad	244	2	subgroups	subgroup	NNS
cord-019001-ralxw4ad	244	3	represent	represent	VBP
cord-019001-ralxw4ad	244	4	a	a	DT
cord-019001-ralxw4ad	244	5	spectrum	spectrum	NN
cord-019001-ralxw4ad	244	6	of	of	IN
cord-019001-ralxw4ad	244	7	etiologies	etiology	NNS
cord-019001-ralxw4ad	244	8	and	and	CC
cord-019001-ralxw4ad	244	9	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	244	10	.	.	.
cord-019001-ralxw4ad	245	1	For	for	IN
cord-019001-ralxw4ad	245	2	example	example	NN
cord-019001-ralxw4ad	245	3	,	,	,
cord-019001-ralxw4ad	245	4	underdevelopment	underdevelopment	NN
cord-019001-ralxw4ad	245	5	of	of	IN
cord-019001-ralxw4ad	245	6	the	the	DT
cord-019001-ralxw4ad	245	7	lung	lung	NN
cord-019001-ralxw4ad	245	8	represents	represent	VBZ
cord-019001-ralxw4ad	245	9	disorders	disorder	NNS
cord-019001-ralxw4ad	245	10	of	of	IN
cord-019001-ralxw4ad	245	11	vascular	vascular	JJ
cord-019001-ralxw4ad	245	12	hypoplasia	hypoplasia	NN
cord-019001-ralxw4ad	245	13	,	,	,
cord-019001-ralxw4ad	245	14	which	which	WDT
cord-019001-ralxw4ad	245	15	are	be	VBP
cord-019001-ralxw4ad	245	16	usually	usually	RB
cord-019001-ralxw4ad	245	17	associated	associate	VBN
cord-019001-ralxw4ad	245	18	with	with	IN
cord-019001-ralxw4ad	245	19	varying	vary	VBG
cord-019001-ralxw4ad	245	20	degrees	degree	NNS
cord-019001-ralxw4ad	245	21	of	of	IN
cord-019001-ralxw4ad	245	22	lung	lung	NN
cord-019001-ralxw4ad	245	23	hypoplasia	hypoplasia	NN
cord-019001-ralxw4ad	245	24	.	.	.
cord-019001-ralxw4ad	246	1	Within	within	IN
cord-019001-ralxw4ad	246	2	this	this	DT
cord-019001-ralxw4ad	246	3	subgroup	subgroup	NN
cord-019001-ralxw4ad	246	4	,	,	,
cord-019001-ralxw4ad	246	5	patients	patient	NNS
cord-019001-ralxw4ad	246	6	with	with	IN
cord-019001-ralxw4ad	246	7	congenital	congenital	JJ
cord-019001-ralxw4ad	246	8	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	246	9	hernia	hernia	NN
cord-019001-ralxw4ad	246	10	have	have	VBP
cord-019001-ralxw4ad	246	11	been	be	VBN
cord-019001-ralxw4ad	246	12	most	most	RBS
cord-019001-ralxw4ad	246	13	thoroughly	thoroughly	RB
cord-019001-ralxw4ad	246	14	investigated	investigate	VBN
cord-019001-ralxw4ad	246	15	.	.	.
cord-019001-ralxw4ad	247	1	Although	although	IN
cord-019001-ralxw4ad	247	2	the	the	DT
cord-019001-ralxw4ad	247	3	structural	structural	JJ
cord-019001-ralxw4ad	247	4	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	247	5	are	be	VBP
cord-019001-ralxw4ad	247	6	greatest	great	JJS
cord-019001-ralxw4ad	247	7	on	on	IN
cord-019001-ralxw4ad	247	8	the	the	DT
cord-019001-ralxw4ad	247	9	side	side	NN
cord-019001-ralxw4ad	247	10	of	of	IN
cord-019001-ralxw4ad	247	11	the	the	DT
cord-019001-ralxw4ad	247	12	hernia	hernia	NN
cord-019001-ralxw4ad	247	13	,	,	,
cord-019001-ralxw4ad	247	14	both	both	DT
cord-019001-ralxw4ad	247	15	of	of	IN
cord-019001-ralxw4ad	247	16	the	the	DT
cord-019001-ralxw4ad	247	17	lungs	lung	NNS
cord-019001-ralxw4ad	247	18	of	of	IN
cord-019001-ralxw4ad	247	19	these	these	DT
cord-019001-ralxw4ad	247	20	patients	patient	NNS
cord-019001-ralxw4ad	247	21	are	be	VBP
cord-019001-ralxw4ad	247	22	smaller	small	JJR
cord-019001-ralxw4ad	247	23	and	and	CC
cord-019001-ralxw4ad	247	24	have	have	VBP
cord-019001-ralxw4ad	247	25	fewer	few	JJR
cord-019001-ralxw4ad	247	26	alveoli	alveolus	NNS
cord-019001-ralxw4ad	247	27	than	than	IN
cord-019001-ralxw4ad	247	28	do	do	VB
cord-019001-ralxw4ad	247	29	lungs	lung	NNS
cord-019001-ralxw4ad	247	30	from	from	IN
cord-019001-ralxw4ad	247	31	a	a	DT
cord-019001-ralxw4ad	247	32	normal	normal	JJ
cord-019001-ralxw4ad	247	33	control	control	NN
cord-019001-ralxw4ad	247	34	population	population	NN
cord-019001-ralxw4ad	247	35	[	[	-LRB-
cord-019001-ralxw4ad	247	36	190	190	CD
cord-019001-ralxw4ad	247	37	]	]	-RRB-
cord-019001-ralxw4ad	247	38	[	[	-LRB-
cord-019001-ralxw4ad	247	39	191	191	CD
cord-019001-ralxw4ad	247	40	]	]	-RRB-
cord-019001-ralxw4ad	247	41	[	[	-LRB-
cord-019001-ralxw4ad	247	42	192	192	CD
cord-019001-ralxw4ad	247	43	]	]	-RRB-
cord-019001-ralxw4ad	247	44	.	.	.
cord-019001-ralxw4ad	248	1	Their	-PRON-	PRP$
cord-019001-ralxw4ad	248	2	lungs	lung	NNS
cord-019001-ralxw4ad	248	3	also	also	RB
cord-019001-ralxw4ad	248	4	have	have	VBP
cord-019001-ralxw4ad	248	5	fewer	few	JJR
cord-019001-ralxw4ad	248	6	vessels	vessel	NNS
cord-019001-ralxw4ad	248	7	per	per	IN
cord-019001-ralxw4ad	248	8	unit	unit	NN
cord-019001-ralxw4ad	248	9	of	of	IN
cord-019001-ralxw4ad	248	10	lung	lung	NN
cord-019001-ralxw4ad	248	11	[	[	-LRB-
cord-019001-ralxw4ad	248	12	192	192	CD
cord-019001-ralxw4ad	248	13	]	]	-RRB-
cord-019001-ralxw4ad	248	14	.	.	.
cord-019001-ralxw4ad	249	1	Thus	thus	RB
cord-019001-ralxw4ad	249	2	,	,	,
cord-019001-ralxw4ad	249	3	the	the	DT
cord-019001-ralxw4ad	249	4	total	total	JJ
cord-019001-ralxw4ad	249	5	cross	cross	JJ
cord-019001-ralxw4ad	249	6	-	-	JJ
cord-019001-ralxw4ad	249	7	sectional	sectional	JJ
cord-019001-ralxw4ad	249	8	area	area	NN
cord-019001-ralxw4ad	249	9	of	of	IN
cord-019001-ralxw4ad	249	10	the	the	DT
cord-019001-ralxw4ad	249	11	vascular	vascular	JJ
cord-019001-ralxw4ad	249	12	bed	bed	NN
cord-019001-ralxw4ad	249	13	is	be	VBZ
cord-019001-ralxw4ad	249	14	markedly	markedly	RB
cord-019001-ralxw4ad	249	15	decreased	decrease	VBN
cord-019001-ralxw4ad	249	16	.	.	.
cord-019001-ralxw4ad	250	1	Furthermore	furthermore	RB
cord-019001-ralxw4ad	250	2	,	,	,
cord-019001-ralxw4ad	250	3	the	the	DT
cord-019001-ralxw4ad	250	4	existing	exist	VBG
cord-019001-ralxw4ad	250	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	250	6	arteries	artery	NNS
cord-019001-ralxw4ad	250	7	have	have	VBP
cord-019001-ralxw4ad	250	8	increased	increase	VBN
cord-019001-ralxw4ad	250	9	muscle	muscle	NN
cord-019001-ralxw4ad	250	10	mass	mass	NN
cord-019001-ralxw4ad	250	11	with	with	IN
cord-019001-ralxw4ad	250	12	medial	medial	JJ
cord-019001-ralxw4ad	250	13	hypertrophy	hypertrophy	NN
cord-019001-ralxw4ad	250	14	in	in	IN
cord-019001-ralxw4ad	250	15	normally	normally	RB
cord-019001-ralxw4ad	250	16	muscularized	muscularize	VBN
cord-019001-ralxw4ad	250	17	arteries	artery	NNS
cord-019001-ralxw4ad	250	18	and	and	CC
cord-019001-ralxw4ad	250	19	an	an	DT
cord-019001-ralxw4ad	250	20	abnormal	abnormal	JJ
cord-019001-ralxw4ad	250	21	extension	extension	NN
cord-019001-ralxw4ad	250	22	of	of	IN
cord-019001-ralxw4ad	250	23	muscle	muscle	NN
cord-019001-ralxw4ad	250	24	into	into	IN
cord-019001-ralxw4ad	250	25	the	the	DT
cord-019001-ralxw4ad	250	26	intra	intra	JJ
cord-019001-ralxw4ad	250	27	-	-	JJ
cord-019001-ralxw4ad	250	28	acinar	acinar	JJ
cord-019001-ralxw4ad	250	29	arteries	artery	NNS
cord-019001-ralxw4ad	250	30	.	.	.
cord-019001-ralxw4ad	251	1	The	the	DT
cord-019001-ralxw4ad	251	2	increased	increased	JJ
cord-019001-ralxw4ad	251	3	muscularization	muscularization	NN
cord-019001-ralxw4ad	251	4	may	may	MD
cord-019001-ralxw4ad	251	5	explain	explain	VB
cord-019001-ralxw4ad	251	6	the	the	DT
cord-019001-ralxw4ad	251	7	labile	labile	JJ
cord-019001-ralxw4ad	251	8	,	,	,
cord-019001-ralxw4ad	251	9	right	right	JJ
cord-019001-ralxw4ad	251	10	-	-	HYPH
cord-019001-ralxw4ad	251	11	to	to	IN
cord-019001-ralxw4ad	251	12	-	-	HYPH
cord-019001-ralxw4ad	251	13	left	leave	VBN
cord-019001-ralxw4ad	251	14	extrapulmonary	extrapulmonary	JJ
cord-019001-ralxw4ad	251	15	shunting	shunting	NN
cord-019001-ralxw4ad	251	16	of	of	IN
cord-019001-ralxw4ad	251	17	blood	blood	NN
cord-019001-ralxw4ad	251	18	seen	see	VBN
cord-019001-ralxw4ad	251	19	in	in	IN
cord-019001-ralxw4ad	251	20	such	such	JJ
cord-019001-ralxw4ad	251	21	patients	patient	NNS
cord-019001-ralxw4ad	251	22	[	[	-LRB-
cord-019001-ralxw4ad	251	23	193	193	CD
cord-019001-ralxw4ad	251	24	,	,	,
cord-019001-ralxw4ad	251	25	194	194	CD
cord-019001-ralxw4ad	251	26	]	]	-RRB-
cord-019001-ralxw4ad	251	27	.	.	.
cord-019001-ralxw4ad	252	1	The	the	DT
cord-019001-ralxw4ad	252	2	response	response	NN
cord-019001-ralxw4ad	252	3	to	to	IN
cord-019001-ralxw4ad	252	4	therapy	therapy	NN
cord-019001-ralxw4ad	252	5	and	and	CC
cord-019001-ralxw4ad	252	6	long	long	JJ
cord-019001-ralxw4ad	252	7	-	-	HYPH
cord-019001-ralxw4ad	252	8	term	term	NN
cord-019001-ralxw4ad	252	9	outcome	outcome	NN
cord-019001-ralxw4ad	252	10	is	be	VBZ
cord-019001-ralxw4ad	252	11	dictated	dictate	VBN
cord-019001-ralxw4ad	252	12	by	by	IN
cord-019001-ralxw4ad	252	13	the	the	DT
cord-019001-ralxw4ad	252	14	degree	degree	NN
cord-019001-ralxw4ad	252	15	of	of	IN
cord-019001-ralxw4ad	252	16	hypoplasia	hypoplasia	NN
cord-019001-ralxw4ad	252	17	of	of	IN
cord-019001-ralxw4ad	252	18	the	the	DT
cord-019001-ralxw4ad	252	19	underlying	underlying	JJ
cord-019001-ralxw4ad	252	20	vasculature	vasculature	NN
cord-019001-ralxw4ad	252	21	.	.	.
cord-019001-ralxw4ad	253	1	Following	follow	VBG
cord-019001-ralxw4ad	253	2	acute	acute	JJ
cord-019001-ralxw4ad	253	3	therapies	therapy	NNS
cord-019001-ralxw4ad	253	4	,	,	,
cord-019001-ralxw4ad	253	5	which	which	WDT
cord-019001-ralxw4ad	253	6	often	often	RB
cord-019001-ralxw4ad	253	7	include	include	VBP
cord-019001-ralxw4ad	253	8	surgical	surgical	JJ
cord-019001-ralxw4ad	253	9	repair	repair	NN
cord-019001-ralxw4ad	253	10	,	,	,
cord-019001-ralxw4ad	253	11	mechanical	mechanical	JJ
cord-019001-ralxw4ad	253	12	ventilation	ventilation	NN
cord-019001-ralxw4ad	253	13	with	with	IN
cord-019001-ralxw4ad	253	14	inhaled	inhale	VBN
cord-019001-ralxw4ad	253	15	NO	no	NN
cord-019001-ralxw4ad	253	16	,	,	,
cord-019001-ralxw4ad	253	17	and	and	CC
cord-019001-ralxw4ad	253	18	extracorporeal	extracorporeal	JJ
cord-019001-ralxw4ad	253	19	support	support	NN
cord-019001-ralxw4ad	253	20	,	,	,
cord-019001-ralxw4ad	253	21	subacute	subacute	JJ
cord-019001-ralxw4ad	253	22	and	and	CC
cord-019001-ralxw4ad	253	23	chronic	chronic	JJ
cord-019001-ralxw4ad	253	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	253	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	253	26	has	have	VBZ
cord-019001-ralxw4ad	253	27	been	be	VBN
cord-019001-ralxw4ad	253	28	increasingly	increasingly	RB
cord-019001-ralxw4ad	253	29	recognized	recognize	VBN
cord-019001-ralxw4ad	253	30	as	as	IN
cord-019001-ralxw4ad	253	31	a	a	DT
cord-019001-ralxw4ad	253	32	major	major	JJ
cord-019001-ralxw4ad	253	33	outcome	outcome	NN
cord-019001-ralxw4ad	253	34	variable	variable	NN
cord-019001-ralxw4ad	253	35	in	in	IN
cord-019001-ralxw4ad	253	36	these	these	DT
cord-019001-ralxw4ad	253	37	patients	patient	NNS
cord-019001-ralxw4ad	253	38	.	.	.
cord-019001-ralxw4ad	254	1	Because	because	IN
cord-019001-ralxw4ad	254	2	ultimately	ultimately	RB
cord-019001-ralxw4ad	254	3	lung	lung	NN
cord-019001-ralxw4ad	254	4	and	and	CC
cord-019001-ralxw4ad	254	5	vascular	vascular	JJ
cord-019001-ralxw4ad	254	6	growth	growth	NN
cord-019001-ralxw4ad	254	7	are	be	VBP
cord-019001-ralxw4ad	254	8	necessary	necessary	JJ
cord-019001-ralxw4ad	254	9	to	to	TO
cord-019001-ralxw4ad	254	10	reverse	reverse	VB
cord-019001-ralxw4ad	254	11	the	the	DT
cord-019001-ralxw4ad	254	12	disease	disease	NN
cord-019001-ralxw4ad	254	13	process	process	NN
cord-019001-ralxw4ad	254	14	,	,	,
cord-019001-ralxw4ad	254	15	aggressive	aggressive	JJ
cord-019001-ralxw4ad	254	16	long	long	JJ
cord-019001-ralxw4ad	254	17	-	-	HYPH
cord-019001-ralxw4ad	254	18	term	term	NN
cord-019001-ralxw4ad	254	19	support	support	NN
cord-019001-ralxw4ad	254	20	with	with	IN
cord-019001-ralxw4ad	254	21	agents	agent	NNS
cord-019001-ralxw4ad	254	22	that	that	WDT
cord-019001-ralxw4ad	254	23	inhibit	inhibit	VBP
cord-019001-ralxw4ad	254	24	vascular	vascular	JJ
cord-019001-ralxw4ad	254	25	remodeling	remodeling	NN
cord-019001-ralxw4ad	254	26	(	(	-LRB-
cord-019001-ralxw4ad	254	27	i.e.	i.e.	FW
cord-019001-ralxw4ad	254	28	,	,	,
cord-019001-ralxw4ad	254	29	ET	ET	NNP
cord-019001-ralxw4ad	254	30	receptor	receptor	NN
cord-019001-ralxw4ad	254	31	antagonists	antagonist	NNS
cord-019001-ralxw4ad	254	32	and	and	CC
cord-019001-ralxw4ad	254	33	PDE	PDE	NNP
cord-019001-ralxw4ad	254	34	inhibitors	inhibitor	NNS
cord-019001-ralxw4ad	254	35	)	)	-RRB-
cord-019001-ralxw4ad	254	36	is	be	VBZ
cord-019001-ralxw4ad	254	37	an	an	DT
cord-019001-ralxw4ad	254	38	emerging	emerge	VBG
cord-019001-ralxw4ad	254	39	treatment	treatment	NN
cord-019001-ralxw4ad	254	40	approach	approach	NN
cord-019001-ralxw4ad	254	41	to	to	TO
cord-019001-ralxw4ad	254	42	support	support	VB
cord-019001-ralxw4ad	254	43	these	these	DT
cord-019001-ralxw4ad	254	44	infants	infant	NNS
cord-019001-ralxw4ad	254	45	as	as	IN
cord-019001-ralxw4ad	254	46	they	-PRON-	PRP
cord-019001-ralxw4ad	254	47	grow	grow	VBP
cord-019001-ralxw4ad	254	48	.	.	.
cord-019001-ralxw4ad	255	1	Maladaptation	maladaptation	NN
cord-019001-ralxw4ad	255	2	of	of	IN
cord-019001-ralxw4ad	255	3	the	the	DT
cord-019001-ralxw4ad	255	4	lung	lung	NN
cord-019001-ralxw4ad	255	5	represents	represent	VBZ
cord-019001-ralxw4ad	255	6	a	a	DT
cord-019001-ralxw4ad	255	7	stress	stress	NN
cord-019001-ralxw4ad	255	8	event	event	NN
cord-019001-ralxw4ad	255	9	at	at	IN
cord-019001-ralxw4ad	255	10	the	the	DT
cord-019001-ralxw4ad	255	11	time	time	NN
cord-019001-ralxw4ad	255	12	of	of	IN
cord-019001-ralxw4ad	255	13	delivery	delivery	NN
cord-019001-ralxw4ad	255	14	that	that	WDT
cord-019001-ralxw4ad	255	15	does	do	VBZ
cord-019001-ralxw4ad	255	16	not	not	RB
cord-019001-ralxw4ad	255	17	allow	allow	VB
cord-019001-ralxw4ad	255	18	the	the	DT
cord-019001-ralxw4ad	255	19	normal	normal	JJ
cord-019001-ralxw4ad	255	20	dilating	dilate	VBG
cord-019001-ralxw4ad	255	21	stimuli	stimulus	NNS
cord-019001-ralxw4ad	255	22	,	,	,
cord-019001-ralxw4ad	255	23	such	such	JJ
cord-019001-ralxw4ad	255	24	as	as	IN
cord-019001-ralxw4ad	255	25	increases	increase	NNS
cord-019001-ralxw4ad	255	26	in	in	IN
cord-019001-ralxw4ad	255	27	systemic	systemic	JJ
cord-019001-ralxw4ad	255	28	arterial	arterial	JJ
cord-019001-ralxw4ad	255	29	pH	ph	NN
cord-019001-ralxw4ad	255	30	and	and	CC
cord-019001-ralxw4ad	255	31	oxygen	oxygen	NN
cord-019001-ralxw4ad	255	32	tension	tension	NN
cord-019001-ralxw4ad	255	33	,	,	,
cord-019001-ralxw4ad	255	34	to	to	TO
cord-019001-ralxw4ad	255	35	occur	occur	VB
cord-019001-ralxw4ad	255	36	.	.	.
cord-019001-ralxw4ad	256	1	This	this	DT
cord-019001-ralxw4ad	256	2	may	may	MD
cord-019001-ralxw4ad	256	3	occur	occur	VB
cord-019001-ralxw4ad	256	4	in	in	IN
cord-019001-ralxw4ad	256	5	the	the	DT
cord-019001-ralxw4ad	256	6	setting	setting	NN
cord-019001-ralxw4ad	256	7	of	of	IN
cord-019001-ralxw4ad	256	8	apnea	apnea	NN
cord-019001-ralxw4ad	256	9	,	,	,
cord-019001-ralxw4ad	256	10	pneumonia	pneumonia	NN
cord-019001-ralxw4ad	256	11	,	,	,
cord-019001-ralxw4ad	256	12	sepsis	sepsis	NN
cord-019001-ralxw4ad	256	13	,	,	,
cord-019001-ralxw4ad	256	14	and	and	CC
cord-019001-ralxw4ad	256	15	aspiration	aspiration	NN
cord-019001-ralxw4ad	256	16	of	of	IN
cord-019001-ralxw4ad	256	17	meconium	meconium	NN
cord-019001-ralxw4ad	256	18	or	or	CC
cord-019001-ralxw4ad	256	19	amniotic	amniotic	NN
cord-019001-ralxw4ad	256	20	fl	fl	NNP
cord-019001-ralxw4ad	256	21	uid	uid	NN
cord-019001-ralxw4ad	256	22	[	[	-LRB-
cord-019001-ralxw4ad	256	23	195	195	CD
cord-019001-ralxw4ad	256	24	]	]	-RRB-
cord-019001-ralxw4ad	256	25	[	[	-LRB-
cord-019001-ralxw4ad	256	26	196	196	CD
cord-019001-ralxw4ad	256	27	]	]	-RRB-
cord-019001-ralxw4ad	256	28	[	[	-LRB-
cord-019001-ralxw4ad	256	29	197	197	CD
cord-019001-ralxw4ad	256	30	]	]	-RRB-
cord-019001-ralxw4ad	256	31	.	.	.
cord-019001-ralxw4ad	257	1	The	the	DT
cord-019001-ralxw4ad	257	2	underlying	underlying	JJ
cord-019001-ralxw4ad	257	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	257	4	vasculature	vasculature	NN
cord-019001-ralxw4ad	257	5	is	be	VBZ
cord-019001-ralxw4ad	257	6	often	often	RB
cord-019001-ralxw4ad	257	7	normal	normal	JJ
cord-019001-ralxw4ad	257	8	,	,	,
cord-019001-ralxw4ad	257	9	and	and	CC
cord-019001-ralxw4ad	257	10	,	,	,
cord-019001-ralxw4ad	257	11	thus	thus	RB
cord-019001-ralxw4ad	257	12	,	,	,
cord-019001-ralxw4ad	257	13	these	these	DT
cord-019001-ralxw4ad	257	14	neonates	neonate	NNS
cord-019001-ralxw4ad	257	15	are	be	VBP
cord-019001-ralxw4ad	257	16	likely	likely	JJ
cord-019001-ralxw4ad	257	17	to	to	TO
cord-019001-ralxw4ad	257	18	respond	respond	VB
cord-019001-ralxw4ad	257	19	to	to	IN
cord-019001-ralxw4ad	257	20	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	257	21	therapy	therapy	NN
cord-019001-ralxw4ad	257	22	and	and	CC
cord-019001-ralxw4ad	257	23	the	the	DT
cord-019001-ralxw4ad	257	24	correction	correction	NN
cord-019001-ralxw4ad	257	25	of	of	IN
cord-019001-ralxw4ad	257	26	contributory	contributory	JJ
cord-019001-ralxw4ad	257	27	metabolic	metabolic	JJ
cord-019001-ralxw4ad	257	28	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	257	29	.	.	.
cord-019001-ralxw4ad	258	1	Maldevelopment	Maldevelopment	NNP
cord-019001-ralxw4ad	258	2	of	of	IN
cord-019001-ralxw4ad	258	3	the	the	DT
cord-019001-ralxw4ad	258	4	lung	lung	NN
cord-019001-ralxw4ad	258	5	represents	represent	VBZ
cord-019001-ralxw4ad	258	6	a	a	DT
cord-019001-ralxw4ad	258	7	group	group	NN
cord-019001-ralxw4ad	258	8	of	of	IN
cord-019001-ralxw4ad	258	9	conditions	condition	NNS
cord-019001-ralxw4ad	258	10	in	in	IN
cord-019001-ralxw4ad	258	11	which	which	WDT
cord-019001-ralxw4ad	258	12	the	the	DT
cord-019001-ralxw4ad	258	13	vasculature	vasculature	NN
cord-019001-ralxw4ad	258	14	is	be	VBZ
cord-019001-ralxw4ad	258	15	thickened	thicken	VBN
cord-019001-ralxw4ad	258	16	and	and	CC
cord-019001-ralxw4ad	258	17	abnormally	abnormally	RB
cord-019001-ralxw4ad	258	18	distributed	distribute	VBN
cord-019001-ralxw4ad	258	19	.	.	.
cord-019001-ralxw4ad	259	1	For	for	IN
cord-019001-ralxw4ad	259	2	example	example	NN
cord-019001-ralxw4ad	259	3	,	,	,
cord-019001-ralxw4ad	259	4	some	some	DT
cord-019001-ralxw4ad	259	5	newborns	newborn	NNS
cord-019001-ralxw4ad	259	6	who	who	WP
cord-019001-ralxw4ad	259	7	die	die	VBP
cord-019001-ralxw4ad	259	8	from	from	IN
cord-019001-ralxw4ad	259	9	persistent	persistent	JJ
cord-019001-ralxw4ad	259	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	259	11	hypertension	hypertension	NN
cord-019001-ralxw4ad	259	12	have	have	VBP
cord-019001-ralxw4ad	259	13	abnormally	abnormally	RB
cord-019001-ralxw4ad	259	14	muscular	muscular	JJ
cord-019001-ralxw4ad	259	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	259	16	vascular	vascular	JJ
cord-019001-ralxw4ad	259	17	beds	bed	NNS
cord-019001-ralxw4ad	259	18	,	,	,
cord-019001-ralxw4ad	259	19	even	even	RB
cord-019001-ralxw4ad	259	20	when	when	WRB
cord-019001-ralxw4ad	259	21	they	-PRON-	PRP
cord-019001-ralxw4ad	259	22	die	die	VBP
cord-019001-ralxw4ad	259	23	on	on	IN
cord-019001-ralxw4ad	259	24	the	the	DT
cord-019001-ralxw4ad	259	25	fi	fi	NNP
cord-019001-ralxw4ad	259	26	rst	rst	NNP
cord-019001-ralxw4ad	259	27	day	day	NN
cord-019001-ralxw4ad	259	28	of	of	IN
cord-019001-ralxw4ad	259	29	life	life	NN
cord-019001-ralxw4ad	259	30	.	.	.
cord-019001-ralxw4ad	260	1	In	in	IN
cord-019001-ralxw4ad	260	2	particular	particular	JJ
cord-019001-ralxw4ad	260	3	,	,	,
cord-019001-ralxw4ad	260	4	they	-PRON-	PRP
cord-019001-ralxw4ad	260	5	have	have	VBP
cord-019001-ralxw4ad	260	6	thickened	thicken	VBN
cord-019001-ralxw4ad	260	7	muscular	muscular	JJ
cord-019001-ralxw4ad	260	8	coats	coat	NNS
cord-019001-ralxw4ad	260	9	in	in	IN
cord-019001-ralxw4ad	260	10	the	the	DT
cord-019001-ralxw4ad	260	11	normally	normally	RB
cord-019001-ralxw4ad	260	12	muscular	muscular	JJ
cord-019001-ralxw4ad	260	13	preacinar	preacinar	NN
cord-019001-ralxw4ad	260	14	arteries	artery	NNS
cord-019001-ralxw4ad	260	15	,	,	,
cord-019001-ralxw4ad	260	16	and	and	CC
cord-019001-ralxw4ad	260	17	extension	extension	NN
cord-019001-ralxw4ad	260	18	of	of	IN
cord-019001-ralxw4ad	260	19	muscle	muscle	NN
cord-019001-ralxw4ad	260	20	into	into	IN
cord-019001-ralxw4ad	260	21	the	the	DT
cord-019001-ralxw4ad	260	22	normally	normally	RB
cord-019001-ralxw4ad	260	23	nonmuscular	nonmuscular	NNP
cord-019001-ralxw4ad	260	24	intra	intra	JJ
cord-019001-ralxw4ad	260	25	-	-	JJ
cord-019001-ralxw4ad	260	26	acinar	acinar	JJ
cord-019001-ralxw4ad	260	27	arteries	artery	NNS
cord-019001-ralxw4ad	260	28	[	[	-LRB-
cord-019001-ralxw4ad	260	29	56	56	CD
cord-019001-ralxw4ad	260	30	,	,	,
cord-019001-ralxw4ad	260	31	57	57	CD
cord-019001-ralxw4ad	260	32	]	]	-RRB-
cord-019001-ralxw4ad	260	33	.	.	.
cord-019001-ralxw4ad	261	1	Because	because	IN
cord-019001-ralxw4ad	261	2	vascular	vascular	JJ
cord-019001-ralxw4ad	261	3	remodeling	remodeling	NN
cord-019001-ralxw4ad	261	4	takes	take	VBZ
cord-019001-ralxw4ad	261	5	time	time	NN
cord-019001-ralxw4ad	261	6	to	to	TO
cord-019001-ralxw4ad	261	7	develop	develop	VB
cord-019001-ralxw4ad	261	8	,	,	,
cord-019001-ralxw4ad	261	9	it	-PRON-	PRP
cord-019001-ralxw4ad	261	10	has	have	VBZ
cord-019001-ralxw4ad	261	11	been	be	VBN
cord-019001-ralxw4ad	261	12	hypothesized	hypothesize	VBN
cord-019001-ralxw4ad	261	13	that	that	IN
cord-019001-ralxw4ad	261	14	this	this	DT
cord-019001-ralxw4ad	261	15	increased	increase	VBN
cord-019001-ralxw4ad	261	16	muscularization	muscularization	NN
cord-019001-ralxw4ad	261	17	is	be	VBZ
cord-019001-ralxw4ad	261	18	caused	cause	VBN
cord-019001-ralxw4ad	261	19	by	by	IN
cord-019001-ralxw4ad	261	20	a	a	DT
cord-019001-ralxw4ad	261	21	chronic	chronic	JJ
cord-019001-ralxw4ad	261	22	intrauterine	intrauterine	JJ
cord-019001-ralxw4ad	261	23	stress	stress	NN
cord-019001-ralxw4ad	261	24	.	.	.
cord-019001-ralxw4ad	262	1	In	in	IN
cord-019001-ralxw4ad	262	2	animal	animal	NN
cord-019001-ralxw4ad	262	3	models	model	NNS
cord-019001-ralxw4ad	262	4	,	,	,
cord-019001-ralxw4ad	262	5	this	this	DT
cord-019001-ralxw4ad	262	6	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	262	7	can	can	MD
cord-019001-ralxw4ad	262	8	be	be	VB
cord-019001-ralxw4ad	262	9	mimicked	mimic	VBN
cord-019001-ralxw4ad	262	10	by	by	IN
cord-019001-ralxw4ad	262	11	chronic	chronic	JJ
cord-019001-ralxw4ad	262	12	placental	placental	NN
cord-019001-ralxw4ad	262	13	insuffi	insuffi	NN
cord-019001-ralxw4ad	262	14	ciency	ciency	NN
cord-019001-ralxw4ad	262	15	,	,	,
cord-019001-ralxw4ad	262	16	fetal	fetal	JJ
cord-019001-ralxw4ad	262	17	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	262	18	,	,	,
cord-019001-ralxw4ad	262	19	chronic	chronic	JJ
cord-019001-ralxw4ad	262	20	constriction	constriction	NN
cord-019001-ralxw4ad	262	21	of	of	IN
cord-019001-ralxw4ad	262	22	the	the	DT
cord-019001-ralxw4ad	262	23	ductus	ductus	NN
cord-019001-ralxw4ad	262	24	arteriosus	arteriosus	NN
cord-019001-ralxw4ad	262	25	,	,	,
cord-019001-ralxw4ad	262	26	and	and	CC
cord-019001-ralxw4ad	262	27	chronic	chronic	JJ
cord-019001-ralxw4ad	262	28	NO	no	DT
cord-019001-ralxw4ad	262	29	inhibition	inhibition	NN
cord-019001-ralxw4ad	262	30	[	[	-LRB-
cord-019001-ralxw4ad	262	31	40	40	CD
cord-019001-ralxw4ad	262	32	,	,	,
cord-019001-ralxw4ad	262	33	55	55	CD
cord-019001-ralxw4ad	262	34	,	,	,
cord-019001-ralxw4ad	262	35	[	[	-LRB-
cord-019001-ralxw4ad	262	36	198	198	CD
cord-019001-ralxw4ad	262	37	]	]	-RRB-
cord-019001-ralxw4ad	262	38	[	[	-LRB-
cord-019001-ralxw4ad	262	39	199	199	CD
cord-019001-ralxw4ad	262	40	]	]	-RRB-
cord-019001-ralxw4ad	262	41	[	[	-LRB-
cord-019001-ralxw4ad	262	42	200	200	CD
cord-019001-ralxw4ad	262	43	]	]	-RRB-
cord-019001-ralxw4ad	262	44	[	[	-LRB-
cord-019001-ralxw4ad	262	45	201	201	CD
cord-019001-ralxw4ad	262	46	]	]	-RRB-
cord-019001-ralxw4ad	262	47	[	[	-LRB-
cord-019001-ralxw4ad	262	48	202	202	CD
cord-019001-ralxw4ad	262	49	]	]	-RRB-
cord-019001-ralxw4ad	262	50	[	[	-LRB-
cord-019001-ralxw4ad	262	51	203	203	CD
cord-019001-ralxw4ad	262	52	]	]	-RRB-
cord-019001-ralxw4ad	262	53	.	.	.
cord-019001-ralxw4ad	263	1	Interestingly	interestingly	RB
cord-019001-ralxw4ad	263	2	,	,	,
cord-019001-ralxw4ad	263	3	PPHN	PPHN	NNP
cord-019001-ralxw4ad	263	4	has	have	VBZ
cord-019001-ralxw4ad	263	5	been	be	VBN
cord-019001-ralxw4ad	263	6	associated	associate	VBN
cord-019001-ralxw4ad	263	7	with	with	IN
cord-019001-ralxw4ad	263	8	maternal	maternal	JJ
cord-019001-ralxw4ad	263	9	indomethacin	indomethacin	NN
cord-019001-ralxw4ad	263	10	use	use	NN
cord-019001-ralxw4ad	263	11	,	,	,
cord-019001-ralxw4ad	263	12	which	which	WDT
cord-019001-ralxw4ad	263	13	causes	cause	VBZ
cord-019001-ralxw4ad	263	14	constriction	constriction	NN
cord-019001-ralxw4ad	263	15	of	of	IN
cord-019001-ralxw4ad	263	16	the	the	DT
cord-019001-ralxw4ad	263	17	ductus	ductus	NN
cord-019001-ralxw4ad	263	18	arteriosus	arteriosus	NN
cord-019001-ralxw4ad	263	19	[	[	-LRB-
cord-019001-ralxw4ad	263	20	204	204	CD
cord-019001-ralxw4ad	263	21	,	,	,
cord-019001-ralxw4ad	263	22	205	205	CD
cord-019001-ralxw4ad	263	23	]	]	-RRB-
cord-019001-ralxw4ad	263	24	.	.	.
cord-019001-ralxw4ad	264	1	The	the	DT
cord-019001-ralxw4ad	264	2	response	response	NN
cord-019001-ralxw4ad	264	3	to	to	IN
cord-019001-ralxw4ad	264	4	therapy	therapy	NN
cord-019001-ralxw4ad	264	5	in	in	IN
cord-019001-ralxw4ad	264	6	neonates	neonate	NNS
cord-019001-ralxw4ad	264	7	with	with	IN
cord-019001-ralxw4ad	264	8	maldevelopment	maldevelopment	NN
cord-019001-ralxw4ad	264	9	of	of	IN
cord-019001-ralxw4ad	264	10	the	the	DT
cord-019001-ralxw4ad	264	11	lung	lung	NN
cord-019001-ralxw4ad	264	12	is	be	VBZ
cord-019001-ralxw4ad	264	13	variable	variable	JJ
cord-019001-ralxw4ad	264	14	and	and	CC
cord-019001-ralxw4ad	264	15	may	may	MD
cord-019001-ralxw4ad	264	16	be	be	VB
cord-019001-ralxw4ad	264	17	related	relate	VBN
cord-019001-ralxw4ad	264	18	to	to	IN
cord-019001-ralxw4ad	264	19	the	the	DT
cord-019001-ralxw4ad	264	20	extent	extent	NN
cord-019001-ralxw4ad	264	21	and	and	CC
cord-019001-ralxw4ad	264	22	type	type	NN
cord-019001-ralxw4ad	264	23	of	of	IN
cord-019001-ralxw4ad	264	24	underlying	underlying	JJ
cord-019001-ralxw4ad	264	25	structural	structural	JJ
cord-019001-ralxw4ad	264	26	vascular	vascular	JJ
cord-019001-ralxw4ad	264	27	pathology	pathology	NN
cord-019001-ralxw4ad	264	28	.	.	.
cord-019001-ralxw4ad	265	1	The	the	DT
cord-019001-ralxw4ad	265	2	primary	primary	JJ
cord-019001-ralxw4ad	265	3	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	265	4	approach	approach	NN
cord-019001-ralxw4ad	265	5	is	be	VBZ
cord-019001-ralxw4ad	265	6	to	to	TO
cord-019001-ralxw4ad	265	7	decrease	decrease	VB
cord-019001-ralxw4ad	265	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	265	9	vascular	vascular	JJ
cord-019001-ralxw4ad	265	10	resistance	resistance	NN
cord-019001-ralxw4ad	265	11	and	and	CC
cord-019001-ralxw4ad	265	12	support	support	NN
cord-019001-ralxw4ad	265	13	myocardial	myocardial	JJ
cord-019001-ralxw4ad	265	14	function	function	NN
cord-019001-ralxw4ad	265	15	.	.	.
cord-019001-ralxw4ad	266	1	The	the	DT
cord-019001-ralxw4ad	266	2	specifi	specifi	NN
cord-019001-ralxw4ad	266	3	c	c	NN
cord-019001-ralxw4ad	266	4	treatment	treatment	NN
cord-019001-ralxw4ad	266	5	modality	modality	NN
cord-019001-ralxw4ad	266	6	depends	depend	VBZ
cord-019001-ralxw4ad	266	7	on	on	IN
cord-019001-ralxw4ad	266	8	the	the	DT
cord-019001-ralxw4ad	266	9	underlying	underlie	VBG
cord-019001-ralxw4ad	266	10	etiology	etiology	NN
cord-019001-ralxw4ad	266	11	.	.	.
cord-019001-ralxw4ad	267	1	If	if	IN
cord-019001-ralxw4ad	267	2	the	the	DT
cord-019001-ralxw4ad	267	3	cause	cause	NN
cord-019001-ralxw4ad	267	4	is	be	VBZ
cord-019001-ralxw4ad	267	5	perinatal	perinatal	JJ
cord-019001-ralxw4ad	267	6	asphyxia	asphyxia	NN
cord-019001-ralxw4ad	267	7	,	,	,
cord-019001-ralxw4ad	267	8	correcting	correct	VBG
cord-019001-ralxw4ad	267	9	alveolar	alveolar	NN
cord-019001-ralxw4ad	267	10	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	267	11	,	,	,
cord-019001-ralxw4ad	267	12	hypercarbia	hypercarbia	NN
cord-019001-ralxw4ad	267	13	,	,	,
cord-019001-ralxw4ad	267	14	and	and	CC
cord-019001-ralxw4ad	267	15	metabolic	metabolic	JJ
cord-019001-ralxw4ad	267	16	acidosis	acidosis	NN
cord-019001-ralxw4ad	267	17	by	by	IN
cord-019001-ralxw4ad	267	18	ventilation	ventilation	NN
cord-019001-ralxw4ad	267	19	with	with	IN
cord-019001-ralxw4ad	267	20	100	100	CD
cord-019001-ralxw4ad	267	21	%	%	NN
cord-019001-ralxw4ad	267	22	oxygen	oxygen	NN
cord-019001-ralxw4ad	267	23	,	,	,
cord-019001-ralxw4ad	267	24	and	and	CC
cord-019001-ralxw4ad	267	25	by	by	IN
cord-019001-ralxw4ad	267	26	administration	administration	NN
cord-019001-ralxw4ad	267	27	of	of	IN
cord-019001-ralxw4ad	267	28	buffer	buffer	NNP
cord-019001-ralxw4ad	267	29	,	,	,
cord-019001-ralxw4ad	267	30	should	should	MD
cord-019001-ralxw4ad	267	31	decrease	decrease	VB
cord-019001-ralxw4ad	267	32	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	267	33	vascular	vascular	JJ
cord-019001-ralxw4ad	267	34	tone	tone	NN
cord-019001-ralxw4ad	267	35	toward	toward	IN
cord-019001-ralxw4ad	267	36	normal	normal	JJ
cord-019001-ralxw4ad	267	37	levels	level	NNS
cord-019001-ralxw4ad	267	38	.	.	.
cord-019001-ralxw4ad	268	1	If	if	IN
cord-019001-ralxw4ad	268	2	parenchymal	parenchymal	NN
cord-019001-ralxw4ad	268	3	disease	disease	NN
cord-019001-ralxw4ad	268	4	(	(	-LRB-
cord-019001-ralxw4ad	268	5	i.e.	i.e.	FW
cord-019001-ralxw4ad	268	6	,	,	,
cord-019001-ralxw4ad	268	7	respiratory	respiratory	JJ
cord-019001-ralxw4ad	268	8	distress	distress	NN
cord-019001-ralxw4ad	268	9	syndrome	syndrome	NN
cord-019001-ralxw4ad	268	10	,	,	,
cord-019001-ralxw4ad	268	11	meconium	meconium	NN
cord-019001-ralxw4ad	268	12	aspiration	aspiration	NN
cord-019001-ralxw4ad	268	13	,	,	,
cord-019001-ralxw4ad	268	14	or	or	CC
cord-019001-ralxw4ad	268	15	pneumonia	pneumonia	NN
cord-019001-ralxw4ad	268	16	)	)	-RRB-
cord-019001-ralxw4ad	268	17	is	be	VBZ
cord-019001-ralxw4ad	268	18	causing	cause	VBG
cord-019001-ralxw4ad	268	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	268	20	vasospasm	vasospasm	NN
cord-019001-ralxw4ad	268	21	due	due	IN
cord-019001-ralxw4ad	268	22	to	to	IN
cord-019001-ralxw4ad	268	23	alveolar	alveolar	JJ
cord-019001-ralxw4ad	268	24	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	268	25	and	and	CC
cord-019001-ralxw4ad	268	26	hypercarbia	hypercarbia	NN
cord-019001-ralxw4ad	268	27	,	,	,
cord-019001-ralxw4ad	268	28	then	then	RB
cord-019001-ralxw4ad	268	29	infl	infl	XX
cord-019001-ralxw4ad	268	30	ation	ation	NN
cord-019001-ralxw4ad	268	31	of	of	IN
cord-019001-ralxw4ad	268	32	the	the	DT
cord-019001-ralxw4ad	268	33	alveoli	alveolus	NNS
cord-019001-ralxw4ad	268	34	with	with	IN
cord-019001-ralxw4ad	268	35	positive	positive	JJ
cord-019001-ralxw4ad	268	36	end	end	NN
cord-019001-ralxw4ad	268	37	-	-	HYPH
cord-019001-ralxw4ad	268	38	expiratory	expiratory	NN
cord-019001-ralxw4ad	268	39	pressure	pressure	NN
cord-019001-ralxw4ad	268	40	,	,	,
cord-019001-ralxw4ad	268	41	surfactant	surfactant	NN
cord-019001-ralxw4ad	268	42	administration	administration	NN
cord-019001-ralxw4ad	268	43	,	,	,
cord-019001-ralxw4ad	268	44	and	and	CC
cord-019001-ralxw4ad	268	45	mechanical	mechanical	JJ
cord-019001-ralxw4ad	268	46	ventilation	ventilation	NN
cord-019001-ralxw4ad	268	47	may	may	MD
cord-019001-ralxw4ad	268	48	reverse	reverse	VB
cord-019001-ralxw4ad	268	49	the	the	DT
cord-019001-ralxw4ad	268	50	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	268	51	hypertension	hypertension	NN
cord-019001-ralxw4ad	268	52	[	[	-LRB-
cord-019001-ralxw4ad	268	53	206	206	CD
cord-019001-ralxw4ad	268	54	]	]	-RRB-
cord-019001-ralxw4ad	268	55	[	[	-LRB-
cord-019001-ralxw4ad	268	56	207	207	CD
cord-019001-ralxw4ad	268	57	]	]	-RRB-
cord-019001-ralxw4ad	268	58	[	[	-LRB-
cord-019001-ralxw4ad	268	59	208	208	CD
cord-019001-ralxw4ad	268	60	]	]	-RRB-
cord-019001-ralxw4ad	268	61	.	.	.
cord-019001-ralxw4ad	269	1	The	the	DT
cord-019001-ralxw4ad	269	2	near	near	JJ
cord-019001-ralxw4ad	269	3	-	-	HYPH
cord-019001-ralxw4ad	269	4	term	term	NN
cord-019001-ralxw4ad	269	5	child	child	NN
cord-019001-ralxw4ad	269	6	can	can	MD
cord-019001-ralxw4ad	269	7	exert	exert	VB
cord-019001-ralxw4ad	269	8	substantial	substantial	JJ
cord-019001-ralxw4ad	269	9	intrathoracic	intrathoracic	JJ
cord-019001-ralxw4ad	269	10	pressure	pressure	NN
cord-019001-ralxw4ad	269	11	opposing	oppose	VBG
cord-019001-ralxw4ad	269	12	mechanical	mechanical	JJ
cord-019001-ralxw4ad	269	13	ventilation	ventilation	NN
cord-019001-ralxw4ad	269	14	;	;	:
cord-019001-ralxw4ad	269	15	thus	thus	RB
cord-019001-ralxw4ad	269	16	,	,	,
cord-019001-ralxw4ad	269	17	sedation	sedation	NN
cord-019001-ralxw4ad	269	18	and	and	CC
cord-019001-ralxw4ad	269	19	occasionally	occasionally	RB
cord-019001-ralxw4ad	269	20	muscle	muscle	NN
cord-019001-ralxw4ad	269	21	paralysis	paralysis	NN
cord-019001-ralxw4ad	269	22	may	may	MD
cord-019001-ralxw4ad	269	23	be	be	VB
cord-019001-ralxw4ad	269	24	necessary	necessary	JJ
cord-019001-ralxw4ad	269	25	to	to	TO
cord-019001-ralxw4ad	269	26	obtain	obtain	VB
cord-019001-ralxw4ad	269	27	stable	stable	JJ
cord-019001-ralxw4ad	269	28	mechanical	mechanical	JJ
cord-019001-ralxw4ad	269	29	ventilation	ventilation	NN
cord-019001-ralxw4ad	269	30	[	[	-LRB-
cord-019001-ralxw4ad	269	31	209	209	CD
cord-019001-ralxw4ad	269	32	]	]	-RRB-
cord-019001-ralxw4ad	269	33	.	.	.
cord-019001-ralxw4ad	270	1	When	when	WRB
cord-019001-ralxw4ad	270	2	treatment	treatment	NN
cord-019001-ralxw4ad	270	3	of	of	IN
cord-019001-ralxw4ad	270	4	the	the	DT
cord-019001-ralxw4ad	270	5	underlying	underlying	JJ
cord-019001-ralxw4ad	270	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	270	7	parenchymal	parenchymal	NN
cord-019001-ralxw4ad	270	8	,	,	,
cord-019001-ralxw4ad	270	9	infectious	infectious	JJ
cord-019001-ralxw4ad	270	10	,	,	,
cord-019001-ralxw4ad	270	11	or	or	CC
cord-019001-ralxw4ad	270	12	infl	infl	NNP
cord-019001-ralxw4ad	270	13	ammatory	ammatory	NNP
cord-019001-ralxw4ad	270	14	disease	disease	NN
cord-019001-ralxw4ad	270	15	is	be	VBZ
cord-019001-ralxw4ad	270	16	ineffective	ineffective	JJ
cord-019001-ralxw4ad	270	17	,	,	,
cord-019001-ralxw4ad	270	18	or	or	CC
cord-019001-ralxw4ad	270	19	if	if	IN
cord-019001-ralxw4ad	270	20	there	there	EX
cord-019001-ralxw4ad	270	21	is	be	VBZ
cord-019001-ralxw4ad	270	22	no	no	DT
cord-019001-ralxw4ad	270	23	such	such	JJ
cord-019001-ralxw4ad	270	24	underlying	underlying	JJ
cord-019001-ralxw4ad	270	25	disease	disease	NN
cord-019001-ralxw4ad	270	26	,	,	,
cord-019001-ralxw4ad	270	27	therapy	therapy	NN
cord-019001-ralxw4ad	270	28	is	be	VBZ
cord-019001-ralxw4ad	270	29	directed	direct	VBN
cord-019001-ralxw4ad	270	30	at	at	IN
cord-019001-ralxw4ad	270	31	reversing	reverse	VBG
cord-019001-ralxw4ad	270	32	abnormal	abnormal	JJ
cord-019001-ralxw4ad	270	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	270	34	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	270	35	.	.	.
cord-019001-ralxw4ad	271	1	This	this	DT
cord-019001-ralxw4ad	271	2	is	be	VBZ
cord-019001-ralxw4ad	271	3	generally	generally	RB
cord-019001-ralxw4ad	271	4	accomplished	accomplish	VBN
cord-019001-ralxw4ad	271	5	with	with	IN
cord-019001-ralxw4ad	271	6	sedation	sedation	NN
cord-019001-ralxw4ad	271	7	,	,	,
cord-019001-ralxw4ad	271	8	mechanical	mechanical	JJ
cord-019001-ralxw4ad	271	9	ventilation	ventilation	NN
cord-019001-ralxw4ad	271	10	with	with	IN
cord-019001-ralxw4ad	271	11	100	100	CD
cord-019001-ralxw4ad	271	12	%	%	NN
cord-019001-ralxw4ad	271	13	oxygen	oxygen	NN
cord-019001-ralxw4ad	271	14	,	,	,
cord-019001-ralxw4ad	271	15	and	and	CC
cord-019001-ralxw4ad	271	16	alkalinization	alkalinization	NN
cord-019001-ralxw4ad	271	17	.	.	.
cord-019001-ralxw4ad	272	1	When	when	WRB
cord-019001-ralxw4ad	272	2	further	further	JJ
cord-019001-ralxw4ad	272	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	272	4	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	272	5	is	be	VBZ
cord-019001-ralxw4ad	272	6	needed	need	VBN
cord-019001-ralxw4ad	272	7	,	,	,
cord-019001-ralxw4ad	272	8	inhaled	inhale	VBN
cord-019001-ralxw4ad	272	9	NO	no	DT
cord-019001-ralxw4ad	272	10	is	be	VBZ
cord-019001-ralxw4ad	272	11	utilized	utilize	VBN
cord-019001-ralxw4ad	272	12	with	with	IN
cord-019001-ralxw4ad	272	13	or	or	CC
cord-019001-ralxw4ad	272	14	without	without	IN
cord-019001-ralxw4ad	272	15	high	high	JJ
cord-019001-ralxw4ad	272	16	-	-	HYPH
cord-019001-ralxw4ad	272	17	frequency	frequency	NN
cord-019001-ralxw4ad	272	18	ventilation	ventilation	NN
cord-019001-ralxw4ad	272	19	.	.	.
cord-019001-ralxw4ad	273	1	In	in	IN
cord-019001-ralxw4ad	273	2	fact	fact	NN
cord-019001-ralxw4ad	273	3	,	,	,
cord-019001-ralxw4ad	273	4	several	several	JJ
cord-019001-ralxw4ad	273	5	multicentered	multicentere	VBN
cord-019001-ralxw4ad	273	6	,	,	,
cord-019001-ralxw4ad	273	7	randomized	randomized	JJ
cord-019001-ralxw4ad	273	8	trials	trial	NNS
cord-019001-ralxw4ad	273	9	have	have	VBP
cord-019001-ralxw4ad	273	10	demonstrated	demonstrate	VBN
cord-019001-ralxw4ad	273	11	that	that	IN
cord-019001-ralxw4ad	273	12	inhaled	inhale	VBN
cord-019001-ralxw4ad	273	13	NO	no	DT
cord-019001-ralxw4ad	273	14	improves	improve	VBZ
cord-019001-ralxw4ad	273	15	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	273	16	and	and	CC
cord-019001-ralxw4ad	273	17	decreases	decrease	VBZ
cord-019001-ralxw4ad	273	18	the	the	DT
cord-019001-ralxw4ad	273	19	need	need	NN
cord-019001-ralxw4ad	273	20	for	for	IN
cord-019001-ralxw4ad	273	21	extracorporeal	extracorporeal	JJ
cord-019001-ralxw4ad	273	22	life	life	NN
cord-019001-ralxw4ad	273	23	support	support	NN
cord-019001-ralxw4ad	273	24	in	in	IN
cord-019001-ralxw4ad	273	25	newborns	newborn	NNS
cord-019001-ralxw4ad	273	26	with	with	IN
cord-019001-ralxw4ad	273	27	persistent	persistent	JJ
cord-019001-ralxw4ad	273	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	273	29	hypertension	hypertension	NN
cord-019001-ralxw4ad	273	30	[	[	-LRB-
cord-019001-ralxw4ad	273	31	117	117	CD
cord-019001-ralxw4ad	273	32	,	,	,
cord-019001-ralxw4ad	273	33	121	121	CD
cord-019001-ralxw4ad	273	34	,	,	,
cord-019001-ralxw4ad	273	35	126	126	CD
cord-019001-ralxw4ad	273	36	)	)	-RRB-
cord-019001-ralxw4ad	273	37	,	,	,
cord-019001-ralxw4ad	273	38	although	although	IN
cord-019001-ralxw4ad	273	39	no	no	DT
cord-019001-ralxw4ad	273	40	differences	difference	NNS
cord-019001-ralxw4ad	273	41	in	in	IN
cord-019001-ralxw4ad	273	42	mortality	mortality	NN
cord-019001-ralxw4ad	273	43	were	be	VBD
cord-019001-ralxw4ad	273	44	noted	note	VBN
cord-019001-ralxw4ad	273	45	.	.	.
cord-019001-ralxw4ad	274	1	The	the	DT
cord-019001-ralxw4ad	274	2	use	use	NN
cord-019001-ralxw4ad	274	3	of	of	IN
cord-019001-ralxw4ad	274	4	extracorporeal	extracorporeal	JJ
cord-019001-ralxw4ad	274	5	membrane	membrane	NN
cord-019001-ralxw4ad	274	6	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	274	7	has	have	VBZ
cord-019001-ralxw4ad	274	8	substantially	substantially	RB
cord-019001-ralxw4ad	274	9	decreased	decrease	VBN
cord-019001-ralxw4ad	274	10	overall	overall	JJ
cord-019001-ralxw4ad	274	11	mortality	mortality	NN
cord-019001-ralxw4ad	274	12	for	for	IN
cord-019001-ralxw4ad	274	13	most	most	JJS
cord-019001-ralxw4ad	274	14	subsets	subset	NNS
cord-019001-ralxw4ad	274	15	of	of	IN
cord-019001-ralxw4ad	274	16	PPHN	PPHN	NNS
cord-019001-ralxw4ad	274	17	.	.	.
cord-019001-ralxw4ad	275	1	However	however	RB
cord-019001-ralxw4ad	275	2	,	,	,
cord-019001-ralxw4ad	275	3	overall	overall	JJ
cord-019001-ralxw4ad	275	4	mortality	mortality	NN
cord-019001-ralxw4ad	275	5	rates	rate	NNS
cord-019001-ralxw4ad	275	6	remain	remain	VBP
cord-019001-ralxw4ad	275	7	substantial	substantial	JJ
cord-019001-ralxw4ad	275	8	at	at	IN
cord-019001-ralxw4ad	275	9	5%-15	5%-15	CD
cord-019001-ralxw4ad	275	10	%	%	NN
cord-019001-ralxw4ad	275	11	[	[	-LRB-
cord-019001-ralxw4ad	275	12	210	210	CD
cord-019001-ralxw4ad	275	13	]	]	-RRB-
cord-019001-ralxw4ad	275	14	[	[	-LRB-
cord-019001-ralxw4ad	275	15	211	211	CD
cord-019001-ralxw4ad	275	16	]	]	-RRB-
cord-019001-ralxw4ad	275	17	[	[	-LRB-
cord-019001-ralxw4ad	275	18	212	212	CD
cord-019001-ralxw4ad	275	19	]	]	-RRB-
cord-019001-ralxw4ad	275	20	[	[	-LRB-
cord-019001-ralxw4ad	275	21	213	213	CD
cord-019001-ralxw4ad	275	22	]	]	-RRB-
cord-019001-ralxw4ad	275	23	.	.	.
cord-019001-ralxw4ad	276	1	The	the	DT
cord-019001-ralxw4ad	276	2	development	development	NN
cord-019001-ralxw4ad	276	3	of	of	IN
cord-019001-ralxw4ad	276	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	276	5	hypertension	hypertension	NN
cord-019001-ralxw4ad	276	6	and	and	CC
cord-019001-ralxw4ad	276	7	increased	increase	VBN
cord-019001-ralxw4ad	276	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	276	9	vascular	vascular	JJ
cord-019001-ralxw4ad	276	10	reactivity	reactivity	NN
cord-019001-ralxw4ad	276	11	is	be	VBZ
cord-019001-ralxw4ad	276	12	associated	associate	VBN
cord-019001-ralxw4ad	276	13	with	with	IN
cord-019001-ralxw4ad	276	14	two	two	CD
cord-019001-ralxw4ad	276	15	major	major	JJ
cord-019001-ralxw4ad	276	16	types	type	NNS
cord-019001-ralxw4ad	276	17	of	of	IN
cord-019001-ralxw4ad	276	18	congenital	congenital	JJ
cord-019001-ralxw4ad	276	19	heart	heart	NN
cord-019001-ralxw4ad	276	20	disease	disease	NN
cord-019001-ralxw4ad	276	21	:	:	:
cord-019001-ralxw4ad	276	22	(	(	-LRB-
cord-019001-ralxw4ad	276	23	1	1	LS
cord-019001-ralxw4ad	276	24	)	)	-RRB-
cord-019001-ralxw4ad	276	25	those	those	DT
cord-019001-ralxw4ad	276	26	with	with	IN
cord-019001-ralxw4ad	276	27	increased	increase	VBN
cord-019001-ralxw4ad	276	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	276	29	blood	blood	NN
cord-019001-ralxw4ad	276	30	fl	fl	NNP
cord-019001-ralxw4ad	276	31	ow	ow	NN
cord-019001-ralxw4ad	276	32	and	and	CC
cord-019001-ralxw4ad	276	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	276	34	arterial	arterial	JJ
cord-019001-ralxw4ad	276	35	pressure	pressure	NN
cord-019001-ralxw4ad	276	36	and	and	CC
cord-019001-ralxw4ad	276	37	(	(	-LRB-
cord-019001-ralxw4ad	276	38	2	2	LS
cord-019001-ralxw4ad	276	39	)	)	-RRB-
cord-019001-ralxw4ad	276	40	those	those	DT
cord-019001-ralxw4ad	276	41	with	with	IN
cord-019001-ralxw4ad	276	42	increased	increase	VBN
cord-019001-ralxw4ad	276	43	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	276	44	venous	venous	JJ
cord-019001-ralxw4ad	276	45	pressure	pressure	NN
cord-019001-ralxw4ad	276	46	[	[	-LRB-
cord-019001-ralxw4ad	276	47	110	110	CD
cord-019001-ralxw4ad	276	48	]	]	-RRB-
cord-019001-ralxw4ad	276	49	[	[	-LRB-
cord-019001-ralxw4ad	276	50	111	111	CD
cord-019001-ralxw4ad	276	51	]	]	-RRB-
cord-019001-ralxw4ad	276	52	[	[	-LRB-
cord-019001-ralxw4ad	276	53	112	112	CD
cord-019001-ralxw4ad	276	54	]	]	-RRB-
cord-019001-ralxw4ad	276	55	169	169	CD
cord-019001-ralxw4ad	276	56	]	]	-RRB-
cord-019001-ralxw4ad	276	57	.	.	.
cord-019001-ralxw4ad	277	1	After	after	IN
cord-019001-ralxw4ad	277	2	birth	birth	NN
cord-019001-ralxw4ad	277	3	,	,	,
cord-019001-ralxw4ad	277	4	large	large	JJ
cord-019001-ralxw4ad	277	5	communications	communication	NNS
cord-019001-ralxw4ad	277	6	at	at	IN
cord-019001-ralxw4ad	277	7	the	the	DT
cord-019001-ralxw4ad	277	8	level	level	NN
cord-019001-ralxw4ad	277	9	of	of	IN
cord-019001-ralxw4ad	277	10	the	the	DT
cord-019001-ralxw4ad	277	11	ventricles	ventricle	NNS
cord-019001-ralxw4ad	277	12	or	or	CC
cord-019001-ralxw4ad	277	13	great	great	JJ
cord-019001-ralxw4ad	277	14	vessels	vessel	NNS
cord-019001-ralxw4ad	277	15	result	result	VBP
cord-019001-ralxw4ad	277	16	in	in	IN
cord-019001-ralxw4ad	277	17	increased	increase	VBN
cord-019001-ralxw4ad	277	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	277	19	blood	blood	NN
cord-019001-ralxw4ad	277	20	fl	fl	NNP
cord-019001-ralxw4ad	277	21	ow	ow	NN
cord-019001-ralxw4ad	277	22	and	and	CC
cord-019001-ralxw4ad	277	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	277	24	arterial	arterial	JJ
cord-019001-ralxw4ad	277	25	pressure	pressure	NN
cord-019001-ralxw4ad	277	26	,	,	,
cord-019001-ralxw4ad	277	27	which	which	WDT
cord-019001-ralxw4ad	277	28	produces	produce	VBZ
cord-019001-ralxw4ad	277	29	progressive	progressive	JJ
cord-019001-ralxw4ad	277	30	structural	structural	JJ
cord-019001-ralxw4ad	277	31	and	and	CC
cord-019001-ralxw4ad	277	32	functional	functional	JJ
cord-019001-ralxw4ad	277	33	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	277	34	of	of	IN
cord-019001-ralxw4ad	277	35	the	the	DT
cord-019001-ralxw4ad	277	36	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	277	37	vasculature	vasculature	NN
cord-019001-ralxw4ad	277	38	[	[	-LRB-
cord-019001-ralxw4ad	277	39	59	59	CD
cord-019001-ralxw4ad	277	40	,	,	,
cord-019001-ralxw4ad	277	41	[	[	-LRB-
cord-019001-ralxw4ad	277	42	106	106	CD
cord-019001-ralxw4ad	277	43	]	]	-RRB-
cord-019001-ralxw4ad	277	44	[	[	-LRB-
cord-019001-ralxw4ad	277	45	107	107	CD
cord-019001-ralxw4ad	277	46	]	]	-RRB-
cord-019001-ralxw4ad	277	47	[	[	-LRB-
cord-019001-ralxw4ad	277	48	108	108	CD
cord-019001-ralxw4ad	277	49	]	]	-RRB-
cord-019001-ralxw4ad	277	50	[	[	-LRB-
cord-019001-ralxw4ad	277	51	109	109	CD
cord-019001-ralxw4ad	277	52	]	]	-RRB-
cord-019001-ralxw4ad	277	53	[	[	-LRB-
cord-019001-ralxw4ad	277	54	110	110	CD
cord-019001-ralxw4ad	277	55	]	]	-RRB-
cord-019001-ralxw4ad	277	56	[	[	-LRB-
cord-019001-ralxw4ad	277	57	214	214	CD
cord-019001-ralxw4ad	277	58	]	]	-RRB-
cord-019001-ralxw4ad	277	59	[	[	-LRB-
cord-019001-ralxw4ad	277	60	215	215	CD
cord-019001-ralxw4ad	277	61	]	]	-RRB-
cord-019001-ralxw4ad	277	62	[	[	-LRB-
cord-019001-ralxw4ad	277	63	216	216	CD
cord-019001-ralxw4ad	277	64	]	]	-RRB-
cord-019001-ralxw4ad	277	65	[	[	-LRB-
cord-019001-ralxw4ad	277	66	217	217	CD
cord-019001-ralxw4ad	277	67	]	]	-RRB-
cord-019001-ralxw4ad	277	68	.	.	.
cord-019001-ralxw4ad	278	1	Similarly	similarly	RB
cord-019001-ralxw4ad	278	2	,	,	,
cord-019001-ralxw4ad	278	3	elevated	elevated	JJ
cord-019001-ralxw4ad	278	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	278	5	venous	venous	JJ
cord-019001-ralxw4ad	278	6	pressure	pressure	NN
cord-019001-ralxw4ad	278	7	results	result	NNS
cord-019001-ralxw4ad	278	8	in	in	IN
cord-019001-ralxw4ad	278	9	progressive	progressive	JJ
cord-019001-ralxw4ad	278	10	increases	increase	NNS
cord-019001-ralxw4ad	278	11	in	in	IN
cord-019001-ralxw4ad	278	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	278	13	venous	venous	JJ
cord-019001-ralxw4ad	278	14	and	and	CC
cord-019001-ralxw4ad	278	15	arterial	arterial	JJ
cord-019001-ralxw4ad	278	16	pressure	pressure	NN
cord-019001-ralxw4ad	278	17	,	,	,
cord-019001-ralxw4ad	278	18	which	which	WDT
cord-019001-ralxw4ad	278	19	produces	produce	VBZ
cord-019001-ralxw4ad	278	20	structural	structural	JJ
cord-019001-ralxw4ad	278	21	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	278	22	of	of	IN
cord-019001-ralxw4ad	278	23	the	the	DT
cord-019001-ralxw4ad	278	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	278	25	vasculature	vasculature	NN
cord-019001-ralxw4ad	278	26	.	.	.
cord-019001-ralxw4ad	279	1	Heath	Heath	NNP
cord-019001-ralxw4ad	279	2	and	and	CC
cord-019001-ralxw4ad	279	3	Edwards	Edwards	NNP
cord-019001-ralxw4ad	279	4	fi	fi	NNP
cord-019001-ralxw4ad	279	5	rst	rst	NNP
cord-019001-ralxw4ad	279	6	described	describe	VBD
cord-019001-ralxw4ad	279	7	the	the	DT
cord-019001-ralxw4ad	279	8	progression	progression	NN
cord-019001-ralxw4ad	279	9	of	of	IN
cord-019001-ralxw4ad	279	10	these	these	DT
cord-019001-ralxw4ad	279	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	279	12	vascular	vascular	JJ
cord-019001-ralxw4ad	279	13	changes	change	NNS
cord-019001-ralxw4ad	279	14	in	in	IN
cord-019001-ralxw4ad	279	15	1958	1958	CD
cord-019001-ralxw4ad	279	16	[	[	-LRB-
cord-019001-ralxw4ad	279	17	217	217	CD
cord-019001-ralxw4ad	279	18	]	]	-RRB-
cord-019001-ralxw4ad	279	19	.	.	.
cord-019001-ralxw4ad	280	1	In	in	IN
cord-019001-ralxw4ad	280	2	their	-PRON-	PRP$
cord-019001-ralxw4ad	280	3	classifi	classifi	NN
cord-019001-ralxw4ad	280	4	cation	cation	NN
cord-019001-ralxw4ad	280	5	,	,	,
cord-019001-ralxw4ad	280	6	changes	change	VBZ
cord-019001-ralxw4ad	280	7	progress	progress	VBP
cord-019001-ralxw4ad	280	8	from	from	IN
cord-019001-ralxw4ad	280	9	medial	medial	JJ
cord-019001-ralxw4ad	280	10	hypertrophy	hypertrophy	NN
cord-019001-ralxw4ad	280	11	(	(	-LRB-
cord-019001-ralxw4ad	280	12	grade	grade	NN
cord-019001-ralxw4ad	280	13	I	I	NNP
cord-019001-ralxw4ad	280	14	)	)	-RRB-
cord-019001-ralxw4ad	280	15	to	to	IN
cord-019001-ralxw4ad	280	16	intimal	intimal	JJ
cord-019001-ralxw4ad	280	17	hyperplasia	hyperplasia	NN
cord-019001-ralxw4ad	280	18	(	(	-LRB-
cord-019001-ralxw4ad	280	19	grade	grade	NN
cord-019001-ralxw4ad	280	20	II	II	NNP
cord-019001-ralxw4ad	280	21	)	)	-RRB-
cord-019001-ralxw4ad	280	22	,	,	,
cord-019001-ralxw4ad	280	23	lumen	lumen	NN
cord-019001-ralxw4ad	280	24	occlusion	occlusion	NN
cord-019001-ralxw4ad	280	25	(	(	-LRB-
cord-019001-ralxw4ad	280	26	grade	grade	NN
cord-019001-ralxw4ad	280	27	III	III	NNP
cord-019001-ralxw4ad	280	28	)	)	-RRB-
cord-019001-ralxw4ad	280	29	,	,	,
cord-019001-ralxw4ad	280	30	arterial	arterial	JJ
cord-019001-ralxw4ad	280	31	dilatation	dilatation	NN
cord-019001-ralxw4ad	280	32	(	(	-LRB-
cord-019001-ralxw4ad	280	33	grade	grade	NN
cord-019001-ralxw4ad	280	34	IV	IV	NNP
cord-019001-ralxw4ad	280	35	)	)	-RRB-
cord-019001-ralxw4ad	280	36	,	,	,
cord-019001-ralxw4ad	280	37	angiomatoid	angiomatoid	NNP
cord-019001-ralxw4ad	280	38	formation	formation	NN
cord-019001-ralxw4ad	280	39	(	(	-LRB-
cord-019001-ralxw4ad	280	40	grade	grade	NN
cord-019001-ralxw4ad	280	41	V	V	NNP
cord-019001-ralxw4ad	280	42	)	)	-RRB-
cord-019001-ralxw4ad	280	43	and	and	CC
cord-019001-ralxw4ad	280	44	fi	fi	NN
cord-019001-ralxw4ad	280	45	brinoid	brinoid	FW
cord-019001-ralxw4ad	280	46	necrosis	necrosis	NN
cord-019001-ralxw4ad	280	47	(	(	-LRB-
cord-019001-ralxw4ad	280	48	grade	grade	NN
cord-019001-ralxw4ad	280	49	VI	VI	NNP
cord-019001-ralxw4ad	280	50	)	)	-RRB-
cord-019001-ralxw4ad	280	51	.	.	.
cord-019001-ralxw4ad	281	1	In	in	IN
cord-019001-ralxw4ad	281	2	addition	addition	NN
cord-019001-ralxw4ad	281	3	,	,	,
cord-019001-ralxw4ad	281	4	morphometric	morphometric	JJ
cord-019001-ralxw4ad	281	5	analysis	analysis	NN
cord-019001-ralxw4ad	281	6	shows	show	VBZ
cord-019001-ralxw4ad	281	7	progression	progression	NN
cord-019001-ralxw4ad	281	8	of	of	IN
cord-019001-ralxw4ad	281	9	disturbed	disturbed	JJ
cord-019001-ralxw4ad	281	10	arterial	arterial	JJ
cord-019001-ralxw4ad	281	11	growth	growth	NN
cord-019001-ralxw4ad	281	12	and	and	CC
cord-019001-ralxw4ad	281	13	remodeling	remodeling	NN
cord-019001-ralxw4ad	281	14	of	of	IN
cord-019001-ralxw4ad	281	15	the	the	DT
cord-019001-ralxw4ad	281	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	281	17	vascular	vascular	JJ
cord-019001-ralxw4ad	281	18	bed	bed	NN
cord-019001-ralxw4ad	281	19	,	,	,
cord-019001-ralxw4ad	281	20	which	which	WDT
cord-019001-ralxw4ad	281	21	correlates	correlate	VBZ
cord-019001-ralxw4ad	281	22	with	with	IN
cord-019001-ralxw4ad	281	23	the	the	DT
cord-019001-ralxw4ad	281	24	aberrant	aberrant	JJ
cord-019001-ralxw4ad	281	25	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	281	26	state	state	NN
cord-019001-ralxw4ad	281	27	of	of	IN
cord-019001-ralxw4ad	281	28	the	the	DT
cord-019001-ralxw4ad	281	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	281	30	circulation	circulation	NN
cord-019001-ralxw4ad	281	31	[	[	-LRB-
cord-019001-ralxw4ad	281	32	108	108	CD
cord-019001-ralxw4ad	281	33	,	,	,
cord-019001-ralxw4ad	281	34	109	109	CD
cord-019001-ralxw4ad	281	35	,	,	,
cord-019001-ralxw4ad	281	36	[	[	-LRB-
cord-019001-ralxw4ad	281	37	214	214	CD
cord-019001-ralxw4ad	281	38	]	]	-RRB-
cord-019001-ralxw4ad	281	39	[	[	-LRB-
cord-019001-ralxw4ad	281	40	215	215	CD
cord-019001-ralxw4ad	281	41	]	]	-RRB-
cord-019001-ralxw4ad	281	42	[	[	-LRB-
cord-019001-ralxw4ad	281	43	216	216	CD
cord-019001-ralxw4ad	281	44	]	]	-RRB-
cord-019001-ralxw4ad	281	45	.	.	.
cord-019001-ralxw4ad	282	1	These	these	DT
cord-019001-ralxw4ad	282	2	changes	change	NNS
cord-019001-ralxw4ad	282	3	are	be	VBP
cord-019001-ralxw4ad	282	4	characterized	characterize	VBN
cord-019001-ralxw4ad	282	5	by	by	IN
cord-019001-ralxw4ad	282	6	(	(	-LRB-
cord-019001-ralxw4ad	282	7	1	1	CD
cord-019001-ralxw4ad	282	8	)	)	-RRB-
cord-019001-ralxw4ad	282	9	abnormal	abnormal	JJ
cord-019001-ralxw4ad	282	10	extension	extension	NN
cord-019001-ralxw4ad	282	11	of	of	IN
cord-019001-ralxw4ad	282	12	vascular	vascular	JJ
cord-019001-ralxw4ad	282	13	smooth	smooth	JJ
cord-019001-ralxw4ad	282	14	muscle	muscle	NN
cord-019001-ralxw4ad	282	15	into	into	IN
cord-019001-ralxw4ad	282	16	small	small	JJ
cord-019001-ralxw4ad	282	17	peripheral	peripheral	JJ
cord-019001-ralxw4ad	282	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	282	19	arteries	artery	NNS
cord-019001-ralxw4ad	282	20	and	and	CC
cord-019001-ralxw4ad	282	21	mild	mild	JJ
cord-019001-ralxw4ad	282	22	medial	medial	JJ
cord-019001-ralxw4ad	282	23	hypertrophy	hypertrophy	NN
cord-019001-ralxw4ad	282	24	of	of	IN
cord-019001-ralxw4ad	282	25	normally	normally	RB
cord-019001-ralxw4ad	282	26	muscular	muscular	JJ
cord-019001-ralxw4ad	282	27	arteries	artery	NNS
cord-019001-ralxw4ad	282	28	(	(	-LRB-
cord-019001-ralxw4ad	282	29	grade	grade	NN
cord-019001-ralxw4ad	282	30	A	A	NNP
cord-019001-ralxw4ad	282	31	)	)	-RRB-
cord-019001-ralxw4ad	282	32	,	,	,
cord-019001-ralxw4ad	282	33	(	(	-LRB-
cord-019001-ralxw4ad	282	34	2	2	LS
cord-019001-ralxw4ad	282	35	)	)	-RRB-
cord-019001-ralxw4ad	282	36	severe	severe	JJ
cord-019001-ralxw4ad	282	37	medial	medial	JJ
cord-019001-ralxw4ad	282	38	hypertrophy	hypertrophy	NN
cord-019001-ralxw4ad	282	39	of	of	IN
cord-019001-ralxw4ad	282	40	normally	normally	RB
cord-019001-ralxw4ad	282	41	muscular	muscular	JJ
cord-019001-ralxw4ad	282	42	arteries	artery	NNS
cord-019001-ralxw4ad	282	43	(	(	-LRB-
cord-019001-ralxw4ad	282	44	grade	grade	NN
cord-019001-ralxw4ad	282	45	B	B	NNP
cord-019001-ralxw4ad	282	46	)	)	-RRB-
cord-019001-ralxw4ad	282	47	,	,	,
cord-019001-ralxw4ad	282	48	and	and	CC
cord-019001-ralxw4ad	282	49	(	(	-LRB-
cord-019001-ralxw4ad	282	50	3	3	LS
cord-019001-ralxw4ad	282	51	)	)	-RRB-
cord-019001-ralxw4ad	282	52	decreased	decrease	VBD
cord-019001-ralxw4ad	282	53	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	282	54	arterial	arterial	JJ
cord-019001-ralxw4ad	282	55	number	number	NN
cord-019001-ralxw4ad	282	56	(	(	-LRB-
cord-019001-ralxw4ad	282	57	grade	grade	NN
cord-019001-ralxw4ad	282	58	C	C	NNP
cord-019001-ralxw4ad	282	59	)	)	-RRB-
cord-019001-ralxw4ad	282	60	.	.	.
cord-019001-ralxw4ad	283	1	Uncorrected	uncorrected	JJ
cord-019001-ralxw4ad	283	2	,	,	,
cord-019001-ralxw4ad	283	3	these	these	DT
cord-019001-ralxw4ad	283	4	vascular	vascular	JJ
cord-019001-ralxw4ad	283	5	changes	change	NNS
cord-019001-ralxw4ad	283	6	result	result	VBP
cord-019001-ralxw4ad	283	7	in	in	IN
cord-019001-ralxw4ad	283	8	decreased	decreased	JJ
cord-019001-ralxw4ad	283	9	cross	cross	JJ
cord-019001-ralxw4ad	283	10	-	-	JJ
cord-019001-ralxw4ad	283	11	sectional	sectional	JJ
cord-019001-ralxw4ad	283	12	area	area	NN
cord-019001-ralxw4ad	283	13	and	and	CC
cord-019001-ralxw4ad	283	14	obliteration	obliteration	NN
cord-019001-ralxw4ad	283	15	of	of	IN
cord-019001-ralxw4ad	283	16	the	the	DT
cord-019001-ralxw4ad	283	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	283	18	vascular	vascular	JJ
cord-019001-ralxw4ad	283	19	bed	bed	NN
cord-019001-ralxw4ad	283	20	and	and	CC
cord-019001-ralxw4ad	283	21	death	death	NN
cord-019001-ralxw4ad	283	22	secondary	secondary	JJ
cord-019001-ralxw4ad	283	23	to	to	IN
cord-019001-ralxw4ad	283	24	severe	severe	JJ
cord-019001-ralxw4ad	283	25	cyanosis	cyanosis	NN
cord-019001-ralxw4ad	283	26	or	or	CC
cord-019001-ralxw4ad	283	27	myocardial	myocardial	JJ
cord-019001-ralxw4ad	283	28	failure	failure	NN
cord-019001-ralxw4ad	283	29	.	.	.
cord-019001-ralxw4ad	284	1	Different	different	JJ
cord-019001-ralxw4ad	284	2	congenital	congenital	JJ
cord-019001-ralxw4ad	284	3	heart	heart	NN
cord-019001-ralxw4ad	284	4	defects	defect	NNS
cord-019001-ralxw4ad	284	5	vary	vary	VBP
cord-019001-ralxw4ad	284	6	considerably	considerably	RB
cord-019001-ralxw4ad	284	7	in	in	IN
cord-019001-ralxw4ad	284	8	the	the	DT
cord-019001-ralxw4ad	284	9	frequency	frequency	NN
cord-019001-ralxw4ad	284	10	and	and	CC
cord-019001-ralxw4ad	284	11	severity	severity	NN
cord-019001-ralxw4ad	284	12	of	of	IN
cord-019001-ralxw4ad	284	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	284	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	284	15	.	.	.
cord-019001-ralxw4ad	285	1	The	the	DT
cord-019001-ralxw4ad	285	2	risks	risk	NNS
cord-019001-ralxw4ad	285	3	and	and	CC
cord-019001-ralxw4ad	285	4	frequencies	frequency	NNS
cord-019001-ralxw4ad	285	5	of	of	IN
cord-019001-ralxw4ad	285	6	developing	develop	VBG
cord-019001-ralxw4ad	285	7	advanced	advanced	JJ
cord-019001-ralxw4ad	285	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	285	9	vascular	vascular	JJ
cord-019001-ralxw4ad	285	10	disease	disease	NN
cord-019001-ralxw4ad	285	11	(	(	-LRB-
cord-019001-ralxw4ad	285	12	PVD	PVD	NNP
cord-019001-ralxw4ad	285	13	)	)	-RRB-
cord-019001-ralxw4ad	285	14	for	for	IN
cord-019001-ralxw4ad	285	15	particular	particular	JJ
cord-019001-ralxw4ad	285	16	heart	heart	NN
cord-019001-ralxw4ad	285	17	defects	defect	NNS
cord-019001-ralxw4ad	285	18	are	be	VBP
cord-019001-ralxw4ad	285	19	summarized	summarize	VBN
cord-019001-ralxw4ad	285	20	in	in	IN
cord-019001-ralxw4ad	285	21	Table	Table	NNP
cord-019001-ralxw4ad	285	22	20	20	CD
cord-019001-ralxw4ad	285	23	.2	.2	CD
cord-019001-ralxw4ad	285	24	.	.	.
cord-019001-ralxw4ad	286	1	Importantly	importantly	RB
cord-019001-ralxw4ad	286	2	,	,	,
cord-019001-ralxw4ad	286	3	children	child	NNS
cord-019001-ralxw4ad	286	4	with	with	IN
cord-019001-ralxw4ad	286	5	trisomy	trisomy	NN
cord-019001-ralxw4ad	286	6	21	21	CD
cord-019001-ralxw4ad	286	7	and	and	CC
cord-019001-ralxw4ad	286	8	congenital	congenital	JJ
cord-019001-ralxw4ad	286	9	heart	heart	NN
cord-019001-ralxw4ad	286	10	defects	defect	NNS
cord-019001-ralxw4ad	286	11	often	often	RB
cord-019001-ralxw4ad	286	12	have	have	VBP
cord-019001-ralxw4ad	286	13	an	an	DT
cord-019001-ralxw4ad	286	14	accelerated	accelerate	VBN
cord-019001-ralxw4ad	286	15	development	development	NN
cord-019001-ralxw4ad	286	16	of	of	IN
cord-019001-ralxw4ad	286	17	advanced	advanced	JJ
cord-019001-ralxw4ad	286	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	286	19	vascular	vascular	JJ
cord-019001-ralxw4ad	286	20	disease	disease	NN
cord-019001-ralxw4ad	286	21	[	[	-LRB-
cord-019001-ralxw4ad	286	22	218	218	CD
cord-019001-ralxw4ad	286	23	]	]	-RRB-
cord-019001-ralxw4ad	286	24	.	.	.
cord-019001-ralxw4ad	287	1	This	this	DT
cord-019001-ralxw4ad	287	2	may	may	MD
cord-019001-ralxw4ad	287	3	be	be	VB
cord-019001-ralxw4ad	287	4	secondary	secondary	JJ
cord-019001-ralxw4ad	287	5	to	to	IN
cord-019001-ralxw4ad	287	6	confounding	confounding	JJ
cord-019001-ralxw4ad	287	7	factors	factor	NNS
cord-019001-ralxw4ad	287	8	such	such	JJ
cord-019001-ralxw4ad	287	9	as	as	IN
cord-019001-ralxw4ad	287	10	airway	airway	JJ
cord-019001-ralxw4ad	287	11	obstruction	obstruction	NN
cord-019001-ralxw4ad	287	12	or	or	CC
cord-019001-ralxw4ad	287	13	another	another	DT
cord-019001-ralxw4ad	287	14	unidentifi	unidentifi	NN
cord-019001-ralxw4ad	287	15	ed	ed	NN
cord-019001-ralxw4ad	287	16	predisposition	predisposition	NN
cord-019001-ralxw4ad	287	17	.	.	.
cord-019001-ralxw4ad	288	1	After	after	IN
cord-019001-ralxw4ad	288	2	surgical	surgical	JJ
cord-019001-ralxw4ad	288	3	correction	correction	NN
cord-019001-ralxw4ad	288	4	,	,	,
cord-019001-ralxw4ad	288	5	early	early	JJ
cord-019001-ralxw4ad	288	6	vascular	vascular	JJ
cord-019001-ralxw4ad	288	7	changes	change	NNS
cord-019001-ralxw4ad	288	8	(	(	-LRB-
cord-019001-ralxw4ad	288	9	grades	grade	NNS
cord-019001-ralxw4ad	288	10	I	I	NNP
cord-019001-ralxw4ad	288	11	-	-	HYPH
cord-019001-ralxw4ad	288	12	III	III	NNP
cord-019001-ralxw4ad	288	13	,	,	,
cord-019001-ralxw4ad	288	14	grades	grade	NNS
cord-019001-ralxw4ad	288	15	A	A	NNP
cord-019001-ralxw4ad	288	16	,	,	,
cord-019001-ralxw4ad	288	17	B	b	NN
cord-019001-ralxw4ad	288	18	)	)	-RRB-
cord-019001-ralxw4ad	288	19	are	be	VBP
cord-019001-ralxw4ad	288	20	reversible	reversible	JJ
cord-019001-ralxw4ad	288	21	;	;	:
cord-019001-ralxw4ad	288	22	however	however	RB
cord-019001-ralxw4ad	288	23	,	,	,
cord-019001-ralxw4ad	288	24	more	more	RBR
cord-019001-ralxw4ad	288	25	severe	severe	JJ
cord-019001-ralxw4ad	288	26	changes	change	NNS
cord-019001-ralxw4ad	288	27	are	be	VBP
cord-019001-ralxw4ad	288	28	irreversible	irreversible	JJ
cord-019001-ralxw4ad	288	29	and	and	CC
cord-019001-ralxw4ad	288	30	progressive	progressive	JJ
cord-019001-ralxw4ad	288	31	.	.	.
cord-019001-ralxw4ad	289	1	Therefore	therefore	RB
cord-019001-ralxw4ad	289	2	,	,	,
cord-019001-ralxw4ad	289	3	the	the	DT
cord-019001-ralxw4ad	289	4	pathophysiologic	pathophysiologic	JJ
cord-019001-ralxw4ad	289	5	state	state	NN
cord-019001-ralxw4ad	289	6	of	of	IN
cord-019001-ralxw4ad	289	7	the	the	DT
cord-019001-ralxw4ad	289	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	289	9	circulation	circulation	NN
cord-019001-ralxw4ad	289	10	is	be	VBZ
cord-019001-ralxw4ad	289	11	the	the	DT
cord-019001-ralxw4ad	289	12	main	main	JJ
cord-019001-ralxw4ad	289	13	determinant	determinant	NN
cord-019001-ralxw4ad	289	14	of	of	IN
cord-019001-ralxw4ad	289	15	the	the	DT
cord-019001-ralxw4ad	289	16	clinical	clinical	JJ
cord-019001-ralxw4ad	289	17	course	course	NN
cord-019001-ralxw4ad	289	18	and	and	CC
cord-019001-ralxw4ad	289	19	the	the	DT
cord-019001-ralxw4ad	289	20	success	success	NN
cord-019001-ralxw4ad	289	21	of	of	IN
cord-019001-ralxw4ad	289	22	surgical	surgical	JJ
cord-019001-ralxw4ad	289	23	treatment	treatment	NN
cord-019001-ralxw4ad	289	24	,	,	,
cord-019001-ralxw4ad	289	25	and	and	CC
cord-019001-ralxw4ad	289	26	it	-PRON-	PRP
cord-019001-ralxw4ad	289	27	explains	explain	VBZ
cord-019001-ralxw4ad	289	28	the	the	DT
cord-019001-ralxw4ad	289	29	trend	trend	NN
cord-019001-ralxw4ad	289	30	toward	toward	IN
cord-019001-ralxw4ad	289	31	early	early	JJ
cord-019001-ralxw4ad	289	32	repair	repair	NN
cord-019001-ralxw4ad	289	33	of	of	IN
cord-019001-ralxw4ad	289	34	congenital	congenital	JJ
cord-019001-ralxw4ad	289	35	heart	heart	NN
cord-019001-ralxw4ad	289	36	defects	defect	NNS
cord-019001-ralxw4ad	289	37	[	[	-LRB-
cord-019001-ralxw4ad	289	38	169	169	CD
cord-019001-ralxw4ad	289	39	]	]	-RRB-
cord-019001-ralxw4ad	289	40	.	.	.
cord-019001-ralxw4ad	290	1	Although	although	IN
cord-019001-ralxw4ad	290	2	early	early	JJ
cord-019001-ralxw4ad	290	3	surgical	surgical	JJ
cord-019001-ralxw4ad	290	4	repair	repair	NN
cord-019001-ralxw4ad	290	5	of	of	IN
cord-019001-ralxw4ad	290	6	congenital	congenital	JJ
cord-019001-ralxw4ad	290	7	heart	heart	NN
cord-019001-ralxw4ad	290	8	defects	defect	NNS
cord-019001-ralxw4ad	290	9	has	have	VBZ
cord-019001-ralxw4ad	290	10	decreased	decrease	VBN
cord-019001-ralxw4ad	290	11	the	the	DT
cord-019001-ralxw4ad	290	12	incidence	incidence	NN
cord-019001-ralxw4ad	290	13	of	of	IN
cord-019001-ralxw4ad	290	14	irreversible	irreversible	JJ
cord-019001-ralxw4ad	290	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	290	16	vascular	vascular	JJ
cord-019001-ralxw4ad	290	17	disease	disease	NN
cord-019001-ralxw4ad	290	18	,	,	,
cord-019001-ralxw4ad	290	19	even	even	RB
cord-019001-ralxw4ad	290	20	those	those	DT
cord-019001-ralxw4ad	290	21	children	child	NNS
cord-019001-ralxw4ad	290	22	with	with	IN
cord-019001-ralxw4ad	290	23	reversible	reversible	JJ
cord-019001-ralxw4ad	290	24	vascular	vascular	JJ
cord-019001-ralxw4ad	290	25	changes	change	NNS
cord-019001-ralxw4ad	290	26	suffer	suffer	VBP
cord-019001-ralxw4ad	290	27	morbidity	morbidity	NN
cord-019001-ralxw4ad	290	28	and	and	CC
cord-019001-ralxw4ad	290	29	mortality	mortality	NN
cord-019001-ralxw4ad	290	30	in	in	IN
cord-019001-ralxw4ad	290	31	the	the	DT
cord-019001-ralxw4ad	290	32	perioperative	perioperative	JJ
cord-019001-ralxw4ad	290	33	period	period	NN
cord-019001-ralxw4ad	290	34	secondary	secondary	JJ
cord-019001-ralxw4ad	290	35	to	to	IN
cord-019001-ralxw4ad	290	36	chronic	chronic	JJ
cord-019001-ralxw4ad	290	37	and/or	and/or	CC
cord-019001-ralxw4ad	290	38	acute	acute	JJ
cord-019001-ralxw4ad	290	39	elevations	elevation	NNS
cord-019001-ralxw4ad	290	40	in	in	IN
cord-019001-ralxw4ad	290	41	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	290	42	vascular	vascular	JJ
cord-019001-ralxw4ad	290	43	resistance	resistance	NN
cord-019001-ralxw4ad	290	44	219	219	CD
cord-019001-ralxw4ad	290	45	]	]	-RRB-
cord-019001-ralxw4ad	290	46	.	.	.
cord-019001-ralxw4ad	291	1	Chronic	chronic	JJ
cord-019001-ralxw4ad	291	2	elevations	elevation	NNS
cord-019001-ralxw4ad	291	3	are	be	VBP
cord-019001-ralxw4ad	291	4	related	relate	VBN
cord-019001-ralxw4ad	291	5	to	to	IN
cord-019001-ralxw4ad	291	6	the	the	DT
cord-019001-ralxw4ad	291	7	structural	structural	JJ
cord-019001-ralxw4ad	291	8	changes	change	NNS
cord-019001-ralxw4ad	291	9	that	that	WDT
cord-019001-ralxw4ad	291	10	decrease	decrease	VBP
cord-019001-ralxw4ad	291	11	the	the	DT
cord-019001-ralxw4ad	291	12	cross	cross	JJ
cord-019001-ralxw4ad	291	13	-	-	JJ
cord-019001-ralxw4ad	291	14	sectional	sectional	JJ
cord-019001-ralxw4ad	291	15	area	area	NN
cord-019001-ralxw4ad	291	16	of	of	IN
cord-019001-ralxw4ad	291	17	the	the	DT
cord-019001-ralxw4ad	291	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	291	19	vascular	vascular	JJ
cord-019001-ralxw4ad	291	20	bed	bed	NN
cord-019001-ralxw4ad	291	21	.	.	.
cord-019001-ralxw4ad	292	1	These	these	DT
cord-019001-ralxw4ad	292	2	alterations	alteration	NNS
cord-019001-ralxw4ad	292	3	may	may	MD
cord-019001-ralxw4ad	292	4	take	take	VB
cord-019001-ralxw4ad	292	5	several	several	JJ
cord-019001-ralxw4ad	292	6	months	month	NNS
cord-019001-ralxw4ad	292	7	to	to	TO
cord-019001-ralxw4ad	292	8	normalize	normalize	VB
cord-019001-ralxw4ad	292	9	following	follow	VBG
cord-019001-ralxw4ad	292	10	surgical	surgical	JJ
cord-019001-ralxw4ad	292	11	repair	repair	NN
cord-019001-ralxw4ad	292	12	.	.	.
cord-019001-ralxw4ad	293	1	Acute	acute	JJ
cord-019001-ralxw4ad	293	2	elevations	elevation	NNS
cord-019001-ralxw4ad	293	3	in	in	IN
cord-019001-ralxw4ad	293	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	293	5	vascular	vascular	JJ
cord-019001-ralxw4ad	293	6	resistance	resistance	NN
cord-019001-ralxw4ad	293	7	are	be	VBP
cord-019001-ralxw4ad	293	8	often	often	RB
cord-019001-ralxw4ad	293	9	seen	see	VBN
cord-019001-ralxw4ad	293	10	immediately	immediately	RB
cord-019001-ralxw4ad	293	11	following	follow	VBG
cord-019001-ralxw4ad	293	12	surgery	surgery	NN
cord-019001-ralxw4ad	293	13	with	with	IN
cord-019001-ralxw4ad	293	14	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	293	15	bypass	bypass	NN
cord-019001-ralxw4ad	293	16	,	,	,
cord-019001-ralxw4ad	293	17	when	when	WRB
cord-019001-ralxw4ad	293	18	there	there	EX
cord-019001-ralxw4ad	293	19	is	be	VBZ
cord-019001-ralxw4ad	293	20	often	often	RB
cord-019001-ralxw4ad	293	21	a	a	DT
cord-019001-ralxw4ad	293	22	period	period	NN
cord-019001-ralxw4ad	293	23	of	of	IN
cord-019001-ralxw4ad	293	24	enhanced	enhanced	JJ
cord-019001-ralxw4ad	293	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	293	26	vascular	vascular	JJ
cord-019001-ralxw4ad	293	27	reactivity	reactivity	NN
cord-019001-ralxw4ad	293	28	[	[	-LRB-
cord-019001-ralxw4ad	293	29	8	8	CD
cord-019001-ralxw4ad	293	30	,	,	,
cord-019001-ralxw4ad	293	31	22	22	CD
cord-019001-ralxw4ad	293	32	,	,	,
cord-019001-ralxw4ad	293	33	98	98	CD
cord-019001-ralxw4ad	293	34	]	]	-RRB-
cord-019001-ralxw4ad	293	35	.	.	.
cord-019001-ralxw4ad	294	1	This	this	DT
cord-019001-ralxw4ad	294	2	period	period	NN
cord-019001-ralxw4ad	294	3	may	may	MD
cord-019001-ralxw4ad	294	4	last	last	VB
cord-019001-ralxw4ad	294	5	up	up	IN
cord-019001-ralxw4ad	294	6	to	to	TO
cord-019001-ralxw4ad	294	7	5	5	CD
cord-019001-ralxw4ad	294	8	-	-	SYM
cord-019001-ralxw4ad	294	9	7	7	CD
cord-019001-ralxw4ad	294	10	days	day	NNS
cord-019001-ralxw4ad	294	11	and	and	CC
cord-019001-ralxw4ad	294	12	is	be	VBZ
cord-019001-ralxw4ad	294	13	most	most	RBS
cord-019001-ralxw4ad	294	14	likely	likely	RB
cord-019001-ralxw4ad	294	15	a	a	DT
cord-019001-ralxw4ad	294	16	manifestation	manifestation	NN
cord-019001-ralxw4ad	294	17	of	of	IN
cord-019001-ralxw4ad	294	18	preexisting	preexist	VBG
cord-019001-ralxw4ad	294	19	aberrant	aberrant	JJ
cord-019001-ralxw4ad	294	20	endothelial	endothelial	JJ
cord-019001-ralxw4ad	294	21	cell	cell	NN
cord-019001-ralxw4ad	294	22	-	-	HYPH
cord-019001-ralxw4ad	294	23	smooth	smooth	JJ
cord-019001-ralxw4ad	294	24	muscle	muscle	NN
cord-019001-ralxw4ad	294	25	cell	cell	NN
cord-019001-ralxw4ad	294	26	interactions	interaction	NNS
cord-019001-ralxw4ad	294	27	that	that	WDT
cord-019001-ralxw4ad	294	28	are	be	VBP
cord-019001-ralxw4ad	294	29	exacerbated	exacerbate	VBN
cord-019001-ralxw4ad	294	30	at	at	IN
cord-019001-ralxw4ad	294	31	the	the	DT
cord-019001-ralxw4ad	294	32	time	time	NN
cord-019001-ralxw4ad	294	33	of	of	IN
cord-019001-ralxw4ad	294	34	surgery	surgery	NN
cord-019001-ralxw4ad	294	35	.	.	.
cord-019001-ralxw4ad	295	1	During	during	IN
cord-019001-ralxw4ad	295	2	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	295	3	bypass	bypass	NN
cord-019001-ralxw4ad	295	4	,	,	,
cord-019001-ralxw4ad	295	5	several	several	JJ
cord-019001-ralxw4ad	295	6	factors	factor	NNS
cord-019001-ralxw4ad	295	7	including	include	VBG
cord-019001-ralxw4ad	295	8	the	the	DT
cord-019001-ralxw4ad	295	9	disruption	disruption	NN
cord-019001-ralxw4ad	295	10	of	of	IN
cord-019001-ralxw4ad	295	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	295	12	blood	blood	NN
cord-019001-ralxw4ad	295	13	fl	fl	NNP
cord-019001-ralxw4ad	295	14	ow	ow	NNP
cord-019001-ralxw4ad	295	15	,	,	,
cord-019001-ralxw4ad	295	16	complement	complement	NN
cord-019001-ralxw4ad	295	17	activation	activation	NN
cord-019001-ralxw4ad	295	18	,	,	,
cord-019001-ralxw4ad	295	19	and	and	CC
cord-019001-ralxw4ad	295	20	neutrophil	neutrophil	NN
cord-019001-ralxw4ad	295	21	activation	activation	NN
cord-019001-ralxw4ad	295	22	induce	induce	VBP
cord-019001-ralxw4ad	295	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	295	24	vascular	vascular	JJ
cord-019001-ralxw4ad	295	25	endothelial	endothelial	JJ
cord-019001-ralxw4ad	295	26	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	295	27	.	.	.
cord-019001-ralxw4ad	296	1	This	this	DT
cord-019001-ralxw4ad	296	2	results	result	VBZ
cord-019001-ralxw4ad	296	3	in	in	IN
cord-019001-ralxw4ad	296	4	an	an	DT
cord-019001-ralxw4ad	296	5	increase	increase	NN
cord-019001-ralxw4ad	296	6	in	in	IN
cord-019001-ralxw4ad	296	7	the	the	DT
cord-019001-ralxw4ad	296	8	production	production	NN
cord-019001-ralxw4ad	296	9	and/or	and/or	CC
cord-019001-ralxw4ad	296	10	release	release	NN
cord-019001-ralxw4ad	296	11	of	of	IN
cord-019001-ralxw4ad	296	12	endothelial	endothelial	JJ
cord-019001-ralxw4ad	296	13	factors	factor	NNS
cord-019001-ralxw4ad	296	14	that	that	WDT
cord-019001-ralxw4ad	296	15	promote	promote	VBP
cord-019001-ralxw4ad	296	16	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	296	17	,	,	,
cord-019001-ralxw4ad	296	18	such	such	JJ
cord-019001-ralxw4ad	296	19	ET-1	ET-1	NNP
cord-019001-ralxw4ad	296	20	and	and	CC
cord-019001-ralxw4ad	296	21	TXA	TXA	NNP
cord-019001-ralxw4ad	296	22	2	2	CD
cord-019001-ralxw4ad	296	23	,	,	,
cord-019001-ralxw4ad	296	24	and	and	CC
cord-019001-ralxw4ad	296	25	a	a	DT
cord-019001-ralxw4ad	296	26	decrease	decrease	NN
cord-019001-ralxw4ad	296	27	in	in	IN
cord-019001-ralxw4ad	296	28	endothelial	endothelial	JJ
cord-019001-ralxw4ad	296	29	relaxing	relaxing	JJ
cord-019001-ralxw4ad	296	30	factors	factor	NNS
cord-019001-ralxw4ad	296	31	,	,	,
cord-019001-ralxw4ad	297	1	most	most	RBS
cord-019001-ralxw4ad	297	2	importantly	importantly	RB
cord-019001-ralxw4ad	297	3	NO	no	DT
cord-019001-ralxw4ad	297	4	[	[	-LRB-
cord-019001-ralxw4ad	297	5	220	220	CD
cord-019001-ralxw4ad	297	6	]	]	-RRB-
cord-019001-ralxw4ad	297	7	.	.	.
cord-019001-ralxw4ad	298	1	This	this	DT
cord-019001-ralxw4ad	298	2	period	period	NN
cord-019001-ralxw4ad	298	3	of	of	IN
cord-019001-ralxw4ad	298	4	extreme	extreme	JJ
cord-019001-ralxw4ad	298	5	reactivity	reactivity	NN
cord-019001-ralxw4ad	298	6	may	may	MD
cord-019001-ralxw4ad	298	7	produce	produce	VB
cord-019001-ralxw4ad	298	8	severe	severe	JJ
cord-019001-ralxw4ad	298	9	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	298	10	,	,	,
cord-019001-ralxw4ad	298	11	acidosis	acidosis	NN
cord-019001-ralxw4ad	298	12	,	,	,
cord-019001-ralxw4ad	298	13	low	low	JJ
cord-019001-ralxw4ad	298	14	cardiac	cardiac	JJ
cord-019001-ralxw4ad	298	15	output	output	NN
cord-019001-ralxw4ad	298	16	,	,	,
cord-019001-ralxw4ad	298	17	and	and	CC
cord-019001-ralxw4ad	298	18	death	death	NN
cord-019001-ralxw4ad	298	19	if	if	IN
cord-019001-ralxw4ad	298	20	not	not	RB
cord-019001-ralxw4ad	298	21	treated	treat	VBN
cord-019001-ralxw4ad	298	22	immediately	immediately	RB
cord-019001-ralxw4ad	298	23	.	.	.
cord-019001-ralxw4ad	299	1	Classically	classically	RB
cord-019001-ralxw4ad	299	2	,	,	,
cord-019001-ralxw4ad	299	3	a	a	DT
cord-019001-ralxw4ad	299	4	preoperative	preoperative	JJ
cord-019001-ralxw4ad	299	5	determination	determination	NN
cord-019001-ralxw4ad	299	6	of	of	IN
cord-019001-ralxw4ad	299	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	299	8	vascular	vascular	JJ
cord-019001-ralxw4ad	299	9	reactivity	reactivity	NN
cord-019001-ralxw4ad	299	10	is	be	VBZ
cord-019001-ralxw4ad	299	11	made	make	VBN
cord-019001-ralxw4ad	299	12	in	in	IN
cord-019001-ralxw4ad	299	13	the	the	DT
cord-019001-ralxw4ad	299	14	cardiac	cardiac	JJ
cord-019001-ralxw4ad	299	15	catheterization	catheterization	NN
cord-019001-ralxw4ad	299	16	laboratory	laboratory	NN
cord-019001-ralxw4ad	299	17	in	in	IN
cord-019001-ralxw4ad	299	18	order	order	NN
cord-019001-ralxw4ad	299	19	to	to	TO
cord-019001-ralxw4ad	299	20	assess	assess	VB
cord-019001-ralxw4ad	299	21	the	the	DT
cord-019001-ralxw4ad	299	22	operability	operability	NN
cord-019001-ralxw4ad	299	23	of	of	IN
cord-019001-ralxw4ad	299	24	a	a	DT
cord-019001-ralxw4ad	299	25	given	give	VBN
cord-019001-ralxw4ad	299	26	patient	patient	NN
cord-019001-ralxw4ad	299	27	,	,	,
cord-019001-ralxw4ad	299	28	that	that	RB
cord-019001-ralxw4ad	299	29	is	is	RB
cord-019001-ralxw4ad	299	30	,	,	,
cord-019001-ralxw4ad	299	31	the	the	DT
cord-019001-ralxw4ad	299	32	degree	degree	NN
cord-019001-ralxw4ad	299	33	to	to	TO
cord-019001-ralxw4ad	299	34	which	which	WDT
cord-019001-ralxw4ad	299	35	the	the	DT
cord-019001-ralxw4ad	299	36	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	299	37	vascular	vascular	JJ
cord-019001-ralxw4ad	299	38	disease	disease	NN
cord-019001-ralxw4ad	299	39	is	be	VBZ
cord-019001-ralxw4ad	299	40	reversible	reversible	JJ
cord-019001-ralxw4ad	299	41	,	,	,
cord-019001-ralxw4ad	299	42	as	as	RB
cord-019001-ralxw4ad	299	43	well	well	RB
cord-019001-ralxw4ad	299	44	as	as	IN
cord-019001-ralxw4ad	299	45	the	the	DT
cord-019001-ralxw4ad	299	46	postoperative	postoperative	JJ
cord-019001-ralxw4ad	299	47	risk	risk	NN
cord-019001-ralxw4ad	299	48	.	.	.
cord-019001-ralxw4ad	300	1	This	this	DT
cord-019001-ralxw4ad	300	2	testing	testing	NN
cord-019001-ralxw4ad	300	3	involves	involve	VBZ
cord-019001-ralxw4ad	300	4	measuring	measure	VBG
cord-019001-ralxw4ad	300	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	300	6	arterial	arterial	JJ
cord-019001-ralxw4ad	300	7	pressure	pressure	NN
cord-019001-ralxw4ad	300	8	and	and	CC
cord-019001-ralxw4ad	300	9	calculating	calculate	VBG
cord-019001-ralxw4ad	300	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	300	11	vascular	vascular	JJ
cord-019001-ralxw4ad	300	12	resistance	resistance	NN
cord-019001-ralxw4ad	300	13	under	under	IN
cord-019001-ralxw4ad	300	14	varying	vary	VBG
cord-019001-ralxw4ad	300	15	conditions	condition	NNS
cord-019001-ralxw4ad	300	16	.	.	.
cord-019001-ralxw4ad	301	1	The	the	DT
cord-019001-ralxw4ad	301	2	vascular	vascular	JJ
cord-019001-ralxw4ad	301	3	resistance	resistance	NN
cord-019001-ralxw4ad	301	4	following	follow	VBG
cord-019001-ralxw4ad	301	5	acute	acute	JJ
cord-019001-ralxw4ad	301	6	maximal	maximal	JJ
cord-019001-ralxw4ad	301	7	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	301	8	therapy	therapy	NN
cord-019001-ralxw4ad	301	9	(	(	-LRB-
cord-019001-ralxw4ad	301	10	e.g.	e.g.	RB
cord-019001-ralxw4ad	301	11	,	,	,
cord-019001-ralxw4ad	301	12	oxygen	oxygen	NN
cord-019001-ralxw4ad	301	13	and	and	CC
cord-019001-ralxw4ad	301	14	NO	no	NN
cord-019001-ralxw4ad	301	15	)	)	-RRB-
cord-019001-ralxw4ad	301	16	represents	represent	VBZ
cord-019001-ralxw4ad	301	17	the	the	DT
cord-019001-ralxw4ad	301	18	degree	degree	NN
cord-019001-ralxw4ad	301	19	of	of	IN
cord-019001-ralxw4ad	301	20	structural	structural	JJ
cord-019001-ralxw4ad	301	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	301	22	vascular	vascular	JJ
cord-019001-ralxw4ad	301	23	disease	disease	NN
cord-019001-ralxw4ad	301	24	that	that	WDT
cord-019001-ralxw4ad	301	25	is	be	VBZ
cord-019001-ralxw4ad	301	26	present	present	JJ
cord-019001-ralxw4ad	301	27	.	.	.
cord-019001-ralxw4ad	302	1	Despite	despite	IN
cord-019001-ralxw4ad	302	2	the	the	DT
cord-019001-ralxw4ad	302	3	frequent	frequent	JJ
cord-019001-ralxw4ad	302	4	utilization	utilization	NN
cord-019001-ralxw4ad	302	5	of	of	IN
cord-019001-ralxw4ad	302	6	such	such	JJ
cord-019001-ralxw4ad	302	7	testing	testing	NN
cord-019001-ralxw4ad	302	8	,	,	,
cord-019001-ralxw4ad	302	9	there	there	EX
cord-019001-ralxw4ad	302	10	is	be	VBZ
cord-019001-ralxw4ad	302	11	no	no	DT
cord-019001-ralxw4ad	302	12	absolute	absolute	JJ
cord-019001-ralxw4ad	302	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	302	14	vascular	vascular	JJ
cord-019001-ralxw4ad	302	15	resistance	resistance	NN
cord-019001-ralxw4ad	302	16	that	that	WDT
cord-019001-ralxw4ad	302	17	is	be	VBZ
cord-019001-ralxw4ad	302	18	universally	universally	RB
cord-019001-ralxw4ad	302	19	considered	consider	VBN
cord-019001-ralxw4ad	302	20	inoperable	inoperable	JJ
cord-019001-ralxw4ad	302	21	.	.	.
cord-019001-ralxw4ad	303	1	In	in	IN
cord-019001-ralxw4ad	303	2	general	general	JJ
cord-019001-ralxw4ad	303	3	,	,	,
cord-019001-ralxw4ad	303	4	a	a	DT
cord-019001-ralxw4ad	303	5	larger	large	JJR
cord-019001-ralxw4ad	303	6	reduction	reduction	NN
cord-019001-ralxw4ad	303	7	in	in	IN
cord-019001-ralxw4ad	303	8	resistance	resistance	NN
cord-019001-ralxw4ad	303	9	in	in	IN
cord-019001-ralxw4ad	303	10	response	response	NN
cord-019001-ralxw4ad	303	11	to	to	IN
cord-019001-ralxw4ad	303	12	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	303	13	therapy	therapy	NN
cord-019001-ralxw4ad	303	14	correlates	correlate	VBZ
cord-019001-ralxw4ad	303	15	with	with	IN
cord-019001-ralxw4ad	303	16	an	an	DT
cord-019001-ralxw4ad	303	17	increased	increased	JJ
cord-019001-ralxw4ad	303	18	chance	chance	NN
cord-019001-ralxw4ad	303	19	of	of	IN
cord-019001-ralxw4ad	303	20	reversibility	reversibility	NN
cord-019001-ralxw4ad	303	21	and	and	CC
cord-019001-ralxw4ad	303	22	a	a	DT
cord-019001-ralxw4ad	303	23	lower	low	JJR
cord-019001-ralxw4ad	303	24	risk	risk	NN
cord-019001-ralxw4ad	303	25	of	of	IN
cord-019001-ralxw4ad	303	26	perioperative	perioperative	JJ
cord-019001-ralxw4ad	303	27	morbidity	morbidity	NN
cord-019001-ralxw4ad	303	28	from	from	IN
cord-019001-ralxw4ad	303	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	303	30	hypertension	hypertension	NN
cord-019001-ralxw4ad	303	31	.	.	.
cord-019001-ralxw4ad	304	1	Recent	recent	JJ
cord-019001-ralxw4ad	304	2	studies	study	NNS
cord-019001-ralxw4ad	304	3	suggest	suggest	VBP
cord-019001-ralxw4ad	304	4	that	that	IN
cord-019001-ralxw4ad	304	5	the	the	DT
cord-019001-ralxw4ad	304	6	combination	combination	NN
cord-019001-ralxw4ad	304	7	of	of	IN
cord-019001-ralxw4ad	304	8	100	100	CD
cord-019001-ralxw4ad	304	9	%	%	NN
cord-019001-ralxw4ad	304	10	oxygen	oxygen	NN
cord-019001-ralxw4ad	304	11	and	and	CC
cord-019001-ralxw4ad	304	12	inhaled	inhale	VBD
cord-019001-ralxw4ad	304	13	NO	no	DT
cord-019001-ralxw4ad	304	14	produces	produce	VBZ
cord-019001-ralxw4ad	304	15	maximal	maximal	JJ
cord-019001-ralxw4ad	304	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	304	17	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	304	18	and	and	CC
cord-019001-ralxw4ad	304	19	has	have	VBZ
cord-019001-ralxw4ad	304	20	some	some	DT
cord-019001-ralxw4ad	304	21	perioperative	perioperative	JJ
cord-019001-ralxw4ad	304	22	predictive	predictive	JJ
cord-019001-ralxw4ad	304	23	value	value	NN
cord-019001-ralxw4ad	304	24	[	[	-LRB-
cord-019001-ralxw4ad	304	25	221	221	CD
cord-019001-ralxw4ad	304	26	,	,	,
cord-019001-ralxw4ad	304	27	222	222	CD
cord-019001-ralxw4ad	304	28	]	]	-RRB-
cord-019001-ralxw4ad	304	29	.	.	.
cord-019001-ralxw4ad	305	1	In	in	IN
cord-019001-ralxw4ad	305	2	fact	fact	NN
cord-019001-ralxw4ad	305	3	,	,	,
cord-019001-ralxw4ad	305	4	a	a	DT
cord-019001-ralxw4ad	305	5	20	20	CD
cord-019001-ralxw4ad	305	6	%	%	NN
cord-019001-ralxw4ad	305	7	decrease	decrease	NN
cord-019001-ralxw4ad	305	8	in	in	IN
cord-019001-ralxw4ad	305	9	the	the	DT
cord-019001-ralxw4ad	305	10	ratio	ratio	NN
cord-019001-ralxw4ad	305	11	of	of	IN
cord-019001-ralxw4ad	305	12	the	the	DT
cord-019001-ralxw4ad	305	13	pulmonary	pulmonary	NN
cord-019001-ralxw4ad	305	14	-	-	HYPH
cord-019001-ralxw4ad	305	15	to	to	IN
cord-019001-ralxw4ad	305	16	-	-	HYPH
cord-019001-ralxw4ad	305	17	systemic	systemic	JJ
cord-019001-ralxw4ad	305	18	vascular	vascular	JJ
cord-019001-ralxw4ad	305	19	resistance	resistance	NN
cord-019001-ralxw4ad	305	20	with	with	IN
cord-019001-ralxw4ad	305	21	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	305	22	therapy	therapy	NN
cord-019001-ralxw4ad	305	23	,	,	,
cord-019001-ralxw4ad	305	24	and	and	CC
cord-019001-ralxw4ad	305	25	a	a	DT
cord-019001-ralxw4ad	305	26	nadir	nadir	NN
cord-019001-ralxw4ad	305	27	in	in	IN
cord-019001-ralxw4ad	305	28	this	this	DT
cord-019001-ralxw4ad	305	29	ratio	ratio	NN
cord-019001-ralxw4ad	305	30	of	of	IN
cord-019001-ralxw4ad	305	31	less	less	JJR
cord-019001-ralxw4ad	305	32	than	than	IN
cord-019001-ralxw4ad	305	33	33	33	CD
cord-019001-ralxw4ad	305	34	%	%	NN
cord-019001-ralxw4ad	305	35	,	,	,
cord-019001-ralxw4ad	305	36	was	be	VBD
cord-019001-ralxw4ad	305	37	97	97	CD
cord-019001-ralxw4ad	305	38	%	%	NN
cord-019001-ralxw4ad	305	39	sensitive	sensitive	JJ
cord-019001-ralxw4ad	305	40	and	and	CC
cord-019001-ralxw4ad	305	41	90	90	CD
cord-019001-ralxw4ad	305	42	%	%	NN
cord-019001-ralxw4ad	305	43	accurate	accurate	JJ
cord-019001-ralxw4ad	305	44	in	in	IN
cord-019001-ralxw4ad	305	45	predicting	predict	VBG
cord-019001-ralxw4ad	305	46	a	a	DT
cord-019001-ralxw4ad	305	47	good	good	JJ
cord-019001-ralxw4ad	305	48	surgical	surgical	JJ
cord-019001-ralxw4ad	305	49	outcome	outcome	NN
cord-019001-ralxw4ad	305	50	.	.	.
cord-019001-ralxw4ad	306	1	Therefore	therefore	RB
cord-019001-ralxw4ad	306	2	,	,	,
cord-019001-ralxw4ad	306	3	the	the	DT
cord-019001-ralxw4ad	306	4	combination	combination	NN
cord-019001-ralxw4ad	306	5	of	of	IN
cord-019001-ralxw4ad	306	6	oxygen	oxygen	NN
cord-019001-ralxw4ad	306	7	and	and	CC
cord-019001-ralxw4ad	306	8	inhaled	inhale	VBN
cord-019001-ralxw4ad	306	9	NO	no	DT
cord-019001-ralxw4ad	306	10	is	be	VBZ
cord-019001-ralxw4ad	306	11	now	now	RB
cord-019001-ralxw4ad	306	12	most	most	RBS
cord-019001-ralxw4ad	306	13	commonly	commonly	RB
cord-019001-ralxw4ad	306	14	used	use	VBN
cord-019001-ralxw4ad	306	15	for	for	IN
cord-019001-ralxw4ad	306	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	306	17	vascular	vascular	JJ
cord-019001-ralxw4ad	306	18	reactivity	reactivity	NN
cord-019001-ralxw4ad	306	19	testing	testing	NN
cord-019001-ralxw4ad	306	20	.	.	.
cord-019001-ralxw4ad	307	1	Reactivity	reactivity	NN
cord-019001-ralxw4ad	307	2	testing	testing	NN
cord-019001-ralxw4ad	307	3	may	may	MD
cord-019001-ralxw4ad	307	4	also	also	RB
cord-019001-ralxw4ad	307	5	be	be	VB
cord-019001-ralxw4ad	307	6	helpful	helpful	JJ
cord-019001-ralxw4ad	307	7	in	in	IN
cord-019001-ralxw4ad	307	8	the	the	DT
cord-019001-ralxw4ad	307	9	intensive	intensive	JJ
cord-019001-ralxw4ad	307	10	care	care	NN
cord-019001-ralxw4ad	307	11	unit	unit	NN
cord-019001-ralxw4ad	307	12	in	in	IN
cord-019001-ralxw4ad	307	13	the	the	DT
cord-019001-ralxw4ad	307	14	setting	setting	NN
cord-019001-ralxw4ad	307	15	of	of	IN
cord-019001-ralxw4ad	307	16	a	a	DT
cord-019001-ralxw4ad	307	17	persistent	persistent	JJ
cord-019001-ralxw4ad	307	18	postoperative	postoperative	JJ
cord-019001-ralxw4ad	307	19	elevation	elevation	NN
cord-019001-ralxw4ad	307	20	of	of	IN
cord-019001-ralxw4ad	307	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	307	22	arterial	arterial	JJ
cord-019001-ralxw4ad	307	23	pressure	pressure	NN
cord-019001-ralxw4ad	307	24	in	in	IN
cord-019001-ralxw4ad	307	25	order	order	NN
cord-019001-ralxw4ad	307	26	to	to	TO
cord-019001-ralxw4ad	307	27	differentiate	differentiate	VB
cord-019001-ralxw4ad	307	28	between	between	IN
cord-019001-ralxw4ad	307	29	residual	residual	JJ
cord-019001-ralxw4ad	307	30	anatomic	anatomic	JJ
cord-019001-ralxw4ad	307	31	defects	defect	NNS
cord-019001-ralxw4ad	307	32	and	and	CC
cord-019001-ralxw4ad	307	33	prolonged	prolong	VBN
cord-019001-ralxw4ad	307	34	periods	period	NNS
cord-019001-ralxw4ad	307	35	of	of	IN
cord-019001-ralxw4ad	307	36	increased	increase	VBN
cord-019001-ralxw4ad	307	37	tone	tone	NN
cord-019001-ralxw4ad	307	38	[	[	-LRB-
cord-019001-ralxw4ad	307	39	118	118	CD
cord-019001-ralxw4ad	307	40	]	]	-RRB-
cord-019001-ralxw4ad	307	41	.	.	.
cord-019001-ralxw4ad	308	1	The	the	DT
cord-019001-ralxw4ad	308	2	optimal	optimal	JJ
cord-019001-ralxw4ad	308	3	treatment	treatment	NN
cord-019001-ralxw4ad	308	4	for	for	IN
cord-019001-ralxw4ad	308	5	perioperative	perioperative	JJ
cord-019001-ralxw4ad	308	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	308	7	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	308	8	morbidity	morbidity	NN
cord-019001-ralxw4ad	308	9	is	be	VBZ
cord-019001-ralxw4ad	308	10	prevention	prevention	NN
cord-019001-ralxw4ad	308	11	with	with	IN
cord-019001-ralxw4ad	308	12	early	early	JJ
cord-019001-ralxw4ad	308	13	surgical	surgical	JJ
cord-019001-ralxw4ad	308	14	repair	repair	NN
cord-019001-ralxw4ad	308	15	.	.	.
cord-019001-ralxw4ad	309	1	It	-PRON-	PRP
cord-019001-ralxw4ad	309	2	is	be	VBZ
cord-019001-ralxw4ad	309	3	increasingly	increasingly	RB
cord-019001-ralxw4ad	309	4	clear	clear	JJ
cord-019001-ralxw4ad	309	5	that	that	IN
cord-019001-ralxw4ad	309	6	the	the	DT
cord-019001-ralxw4ad	309	7	longer	long	JJR
cord-019001-ralxw4ad	309	8	the	the	DT
cord-019001-ralxw4ad	309	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	309	10	vasculature	vasculature	NN
cord-019001-ralxw4ad	309	11	is	be	VBZ
cord-019001-ralxw4ad	309	12	exposed	expose	VBN
cord-019001-ralxw4ad	309	13	to	to	IN
cord-019001-ralxw4ad	309	14	the	the	DT
cord-019001-ralxw4ad	309	15	abnormal	abnormal	JJ
cord-019001-ralxw4ad	309	16	forces	force	NNS
cord-019001-ralxw4ad	309	17	associated	associate	VBN
cord-019001-ralxw4ad	309	18	with	with	IN
cord-019001-ralxw4ad	309	19	increased	increase	VBN
cord-019001-ralxw4ad	309	20	blood	blood	NN
cord-019001-ralxw4ad	309	21	fl	fl	NNP
cord-019001-ralxw4ad	309	22	ow	ow	UH
cord-019001-ralxw4ad	309	23	and/or	and/or	CC
cord-019001-ralxw4ad	309	24	pressure	pressure	NN
cord-019001-ralxw4ad	309	25	,	,	,
cord-019001-ralxw4ad	309	26	the	the	DT
cord-019001-ralxw4ad	309	27	greater	great	JJR
cord-019001-ralxw4ad	309	28	the	the	DT
cord-019001-ralxw4ad	309	29	risk	risk	NN
cord-019001-ralxw4ad	309	30	of	of	IN
cord-019001-ralxw4ad	309	31	perioperative	perioperative	JJ
cord-019001-ralxw4ad	309	32	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	309	33	vascular	vascular	JJ
cord-019001-ralxw4ad	309	34	reactivity	reactivity	NN
cord-019001-ralxw4ad	309	35	.	.	.
cord-019001-ralxw4ad	310	1	Following	follow	VBG
cord-019001-ralxw4ad	310	2	surgery	surgery	NN
cord-019001-ralxw4ad	310	3	,	,	,
cord-019001-ralxw4ad	310	4	the	the	DT
cord-019001-ralxw4ad	310	5	goal	goal	NN
cord-019001-ralxw4ad	310	6	of	of	IN
cord-019001-ralxw4ad	310	7	perioperative	perioperative	JJ
cord-019001-ralxw4ad	310	8	management	management	NN
cord-019001-ralxw4ad	310	9	is	be	VBZ
cord-019001-ralxw4ad	310	10	to	to	TO
cord-019001-ralxw4ad	310	11	minimize	minimize	VB
cord-019001-ralxw4ad	310	12	active	active	JJ
cord-019001-ralxw4ad	310	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	310	14	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	310	15	during	during	IN
cord-019001-ralxw4ad	310	16	the	the	DT
cord-019001-ralxw4ad	310	17	period	period	NN
cord-019001-ralxw4ad	310	18	of	of	IN
cord-019001-ralxw4ad	310	19	exaggerated	exaggerated	JJ
cord-019001-ralxw4ad	310	20	reactivity	reactivity	NN
cord-019001-ralxw4ad	310	21	and	and	CC
cord-019001-ralxw4ad	310	22	support	support	VB
cord-019001-ralxw4ad	310	23	the	the	DT
cord-019001-ralxw4ad	310	24	right	right	JJ
cord-019001-ralxw4ad	310	25	ventricle	ventricle	NN
cord-019001-ralxw4ad	310	26	.	.	.
cord-019001-ralxw4ad	311	1	To	to	IN
cord-019001-ralxw4ad	311	2	this	this	DT
cord-019001-ralxw4ad	311	3	end	end	NN
cord-019001-ralxw4ad	311	4	,	,	,
cord-019001-ralxw4ad	311	5	avoidance	avoidance	NN
cord-019001-ralxw4ad	311	6	of	of	IN
cord-019001-ralxw4ad	311	7	those	those	DT
cord-019001-ralxw4ad	311	8	stimuli	stimulus	NNS
cord-019001-ralxw4ad	311	9	that	that	WDT
cord-019001-ralxw4ad	311	10	increase	increase	VBP
cord-019001-ralxw4ad	311	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	311	12	vascular	vascular	JJ
cord-019001-ralxw4ad	311	13	resistance	resistance	NN
cord-019001-ralxw4ad	311	14	(	(	-LRB-
cord-019001-ralxw4ad	311	15	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	311	16	,	,	,
cord-019001-ralxw4ad	311	17	acidosis	acidosis	NN
cord-019001-ralxw4ad	311	18	,	,	,
cord-019001-ralxw4ad	311	19	pain	pain	NN
cord-019001-ralxw4ad	311	20	,	,	,
cord-019001-ralxw4ad	311	21	agitation	agitation	NN
cord-019001-ralxw4ad	311	22	,	,	,
cord-019001-ralxw4ad	311	23	increased	increase	VBN
cord-019001-ralxw4ad	311	24	intrathoracic	intrathoracic	JJ
cord-019001-ralxw4ad	311	25	pressure	pressure	NN
cord-019001-ralxw4ad	311	26	)	)	-RRB-
cord-019001-ralxw4ad	311	27	is	be	VBZ
cord-019001-ralxw4ad	311	28	critical	critical	JJ
cord-019001-ralxw4ad	311	29	.	.	.
cord-019001-ralxw4ad	312	1	Continuous	continuous	JJ
cord-019001-ralxw4ad	312	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	312	3	arterial	arterial	NN
cord-019001-ralxw4ad	312	4	and	and	CC
cord-019001-ralxw4ad	312	5	right	right	JJ
cord-019001-ralxw4ad	312	6	atrial	atrial	JJ
cord-019001-ralxw4ad	312	7	pressure	pressure	NN
cord-019001-ralxw4ad	312	8	monitoring	monitoring	NN
cord-019001-ralxw4ad	312	9	is	be	VBZ
cord-019001-ralxw4ad	312	10	often	often	RB
cord-019001-ralxw4ad	312	11	helpful	helpful	JJ
cord-019001-ralxw4ad	312	12	by	by	IN
cord-019001-ralxw4ad	312	13	allowing	allow	VBG
cord-019001-ralxw4ad	312	14	prompt	prompt	JJ
cord-019001-ralxw4ad	312	15	recognition	recognition	NN
cord-019001-ralxw4ad	312	16	of	of	IN
cord-019001-ralxw4ad	312	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	312	18	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	312	19	crises	crisis	NNS
cord-019001-ralxw4ad	312	20	and	and	CC
cord-019001-ralxw4ad	312	21	evaluation	evaluation	NN
cord-019001-ralxw4ad	312	22	of	of	IN
cord-019001-ralxw4ad	312	23	the	the	DT
cord-019001-ralxw4ad	312	24	response	response	NN
cord-019001-ralxw4ad	312	25	to	to	IN
cord-019001-ralxw4ad	312	26	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	312	27	maneuvers	maneuver	NNS
cord-019001-ralxw4ad	312	28	.	.	.
cord-019001-ralxw4ad	313	1	Monitoring	monitor	VBG
cord-019001-ralxw4ad	313	2	systemic	systemic	JJ
cord-019001-ralxw4ad	313	3	arterial	arterial	JJ
cord-019001-ralxw4ad	313	4	pressure	pressure	NN
cord-019001-ralxw4ad	313	5	and	and	CC
cord-019001-ralxw4ad	313	6	systemic	systemic	JJ
cord-019001-ralxw4ad	313	7	arterial	arterial	JJ
cord-019001-ralxw4ad	313	8	oxygen	oxygen	NN
cord-019001-ralxw4ad	313	9	saturation	saturation	NN
cord-019001-ralxw4ad	313	10	is	be	VBZ
cord-019001-ralxw4ad	313	11	essential	essential	JJ
cord-019001-ralxw4ad	313	12	in	in	IN
cord-019001-ralxw4ad	313	13	that	that	IN
cord-019001-ralxw4ad	313	14	it	-PRON-	PRP
cord-019001-ralxw4ad	313	15	allows	allow	VBZ
cord-019001-ralxw4ad	313	16	changes	change	NNS
cord-019001-ralxw4ad	313	17	in	in	IN
cord-019001-ralxw4ad	313	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	313	19	arterial	arterial	JJ
cord-019001-ralxw4ad	313	20	pressure	pressure	NN
cord-019001-ralxw4ad	313	21	to	to	TO
cord-019001-ralxw4ad	313	22	be	be	VB
cord-019001-ralxw4ad	313	23	interpreted	interpret	VBN
cord-019001-ralxw4ad	313	24	in	in	IN
cord-019001-ralxw4ad	313	25	the	the	DT
cord-019001-ralxw4ad	313	26	context	context	NN
cord-019001-ralxw4ad	313	27	of	of	IN
cord-019001-ralxw4ad	313	28	the	the	DT
cord-019001-ralxw4ad	313	29	total	total	JJ
cord-019001-ralxw4ad	313	30	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	313	31	response	response	NN
cord-019001-ralxw4ad	313	32	.	.	.
cord-019001-ralxw4ad	314	1	For	for	IN
cord-019001-ralxw4ad	314	2	example	example	NN
cord-019001-ralxw4ad	314	3	,	,	,
cord-019001-ralxw4ad	314	4	if	if	IN
cord-019001-ralxw4ad	314	5	systemic	systemic	JJ
cord-019001-ralxw4ad	314	6	and	and	CC
cord-019001-ralxw4ad	314	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	314	8	arterial	arterial	JJ
cord-019001-ralxw4ad	314	9	pressures	pressure	NNS
cord-019001-ralxw4ad	314	10	increase	increase	VBP
cord-019001-ralxw4ad	314	11	in	in	IN
cord-019001-ralxw4ad	314	12	response	response	NN
cord-019001-ralxw4ad	314	13	to	to	IN
cord-019001-ralxw4ad	314	14	pain	pain	NN
cord-019001-ralxw4ad	314	15	and	and	CC
cord-019001-ralxw4ad	314	16	agitation	agitation	NN
cord-019001-ralxw4ad	314	17	,	,	,
cord-019001-ralxw4ad	314	18	but	but	CC
cord-019001-ralxw4ad	314	19	right	right	JJ
cord-019001-ralxw4ad	314	20	atrial	atrial	JJ
cord-019001-ralxw4ad	314	21	pressure	pressure	NN
cord-019001-ralxw4ad	314	22	does	do	VBZ
cord-019001-ralxw4ad	314	23	not	not	RB
cord-019001-ralxw4ad	314	24	increase	increase	VB
cord-019001-ralxw4ad	314	25	,	,	,
cord-019001-ralxw4ad	314	26	and	and	CC
cord-019001-ralxw4ad	314	27	systemic	systemic	JJ
cord-019001-ralxw4ad	314	28	perfusion	perfusion	NN
cord-019001-ralxw4ad	314	29	and	and	CC
cord-019001-ralxw4ad	314	30	oxygen	oxygen	NN
cord-019001-ralxw4ad	314	31	saturation	saturation	NN
cord-019001-ralxw4ad	314	32	remain	remain	VBP
cord-019001-ralxw4ad	314	33	adequate	adequate	JJ
cord-019001-ralxw4ad	314	34	,	,	,
cord-019001-ralxw4ad	314	35	then	then	RB
cord-019001-ralxw4ad	314	36	specifi	specifi	NNP
cord-019001-ralxw4ad	314	37	c	c	NNP
cord-019001-ralxw4ad	314	38	treatment	treatment	NN
cord-019001-ralxw4ad	314	39	directed	direct	VBN
cord-019001-ralxw4ad	314	40	at	at	IN
cord-019001-ralxw4ad	314	41	the	the	DT
cord-019001-ralxw4ad	314	42	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	314	43	vasculature	vasculature	NN
cord-019001-ralxw4ad	314	44	is	be	VBZ
cord-019001-ralxw4ad	314	45	not	not	RB
cord-019001-ralxw4ad	314	46	necessary	necessary	JJ
cord-019001-ralxw4ad	314	47	.	.	.
cord-019001-ralxw4ad	315	1	Conversely	conversely	RB
cord-019001-ralxw4ad	315	2	,	,	,
cord-019001-ralxw4ad	315	3	increases	increase	NNS
cord-019001-ralxw4ad	315	4	in	in	IN
cord-019001-ralxw4ad	315	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	315	6	arterial	arterial	JJ
cord-019001-ralxw4ad	315	7	pressure	pressure	NN
cord-019001-ralxw4ad	315	8	that	that	WDT
cord-019001-ralxw4ad	315	9	are	be	VBP
cord-019001-ralxw4ad	315	10	associated	associate	VBN
cord-019001-ralxw4ad	315	11	with	with	IN
cord-019001-ralxw4ad	315	12	increased	increase	VBN
cord-019001-ralxw4ad	315	13	right	right	JJ
cord-019001-ralxw4ad	315	14	atrial	atrial	JJ
cord-019001-ralxw4ad	315	15	pressure	pressure	NN
cord-019001-ralxw4ad	315	16	,	,	,
cord-019001-ralxw4ad	315	17	decreased	decrease	VBD
cord-019001-ralxw4ad	315	18	systemic	systemic	JJ
cord-019001-ralxw4ad	315	19	pressure	pressure	NN
cord-019001-ralxw4ad	315	20	,	,	,
cord-019001-ralxw4ad	315	21	and/or	and/or	CC
cord-019001-ralxw4ad	315	22	decreased	decrease	VBD
cord-019001-ralxw4ad	315	23	systemic	systemic	JJ
cord-019001-ralxw4ad	315	24	saturation	saturation	NN
cord-019001-ralxw4ad	315	25	might	may	MD
cord-019001-ralxw4ad	315	26	herald	herald	VB
cord-019001-ralxw4ad	315	27	imminent	imminent	JJ
cord-019001-ralxw4ad	315	28	collapse	collapse	NN
cord-019001-ralxw4ad	315	29	.	.	.
cord-019001-ralxw4ad	316	1	The	the	DT
cord-019001-ralxw4ad	316	2	objective	objective	NN
cord-019001-ralxw4ad	316	3	of	of	IN
cord-019001-ralxw4ad	316	4	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	316	5	therapy	therapy	NN
cord-019001-ralxw4ad	316	6	is	be	VBZ
cord-019001-ralxw4ad	316	7	to	to	TO
cord-019001-ralxw4ad	316	8	decrease	decrease	VB
cord-019001-ralxw4ad	316	9	right	right	JJ
cord-019001-ralxw4ad	316	10	ventricular	ventricular	JJ
cord-019001-ralxw4ad	316	11	afterload	afterload	NN
cord-019001-ralxw4ad	316	12	and	and	CC
cord-019001-ralxw4ad	316	13	prevent	prevent	VB
cord-019001-ralxw4ad	316	14	acute	acute	JJ
cord-019001-ralxw4ad	316	15	increases	increase	NNS
cord-019001-ralxw4ad	316	16	in	in	IN
cord-019001-ralxw4ad	316	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	316	18	arterial	arterial	JJ
cord-019001-ralxw4ad	316	19	pressure	pressure	NN
cord-019001-ralxw4ad	316	20	.	.	.
cord-019001-ralxw4ad	317	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	317	2	NO	NO	NNP
cord-019001-ralxw4ad	317	3	,	,	,
cord-019001-ralxw4ad	317	4	in	in	IN
cord-019001-ralxw4ad	317	5	combination	combination	NN
cord-019001-ralxw4ad	317	6	with	with	IN
cord-019001-ralxw4ad	317	7	oxygen	oxygen	NN
cord-019001-ralxw4ad	317	8	,	,	,
cord-019001-ralxw4ad	317	9	has	have	VBZ
cord-019001-ralxw4ad	317	10	been	be	VBN
cord-019001-ralxw4ad	317	11	increasingly	increasingly	RB
cord-019001-ralxw4ad	317	12	utilized	utilize	VBN
cord-019001-ralxw4ad	317	13	because	because	IN
cord-019001-ralxw4ad	317	14	of	of	IN
cord-019001-ralxw4ad	317	15	its	-PRON-	PRP$
cord-019001-ralxw4ad	317	16	potent	potent	JJ
cord-019001-ralxw4ad	317	17	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	317	18	effects	effect	NNS
cord-019001-ralxw4ad	317	19	,	,	,
cord-019001-ralxw4ad	317	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	317	21	selectivity	selectivity	NN
cord-019001-ralxw4ad	317	22	,	,	,
cord-019001-ralxw4ad	317	23	and	and	CC
cord-019001-ralxw4ad	317	24	rapid	rapid	JJ
cord-019001-ralxw4ad	317	25	onset	onset	NN
cord-019001-ralxw4ad	317	26	and	and	CC
cord-019001-ralxw4ad	317	27	elimination	elimination	NN
cord-019001-ralxw4ad	317	28	(	(	-LRB-
cord-019001-ralxw4ad	317	29	see	see	VB
cord-019001-ralxw4ad	317	30	earlier	early	RBR
cord-019001-ralxw4ad	317	31	)	)	-RRB-
cord-019001-ralxw4ad	317	32	.	.	.
cord-019001-ralxw4ad	318	1	Several	several	JJ
cord-019001-ralxw4ad	318	2	studies	study	NNS
cord-019001-ralxw4ad	318	3	demonstrate	demonstrate	VBP
cord-019001-ralxw4ad	318	4	its	-PRON-	PRP$
cord-019001-ralxw4ad	318	5	potent	potent	JJ
cord-019001-ralxw4ad	318	6	vasodilating	vasodilating	NN
cord-019001-ralxw4ad	318	7	effects	effect	NNS
cord-019001-ralxw4ad	318	8	in	in	IN
cord-019001-ralxw4ad	318	9	this	this	DT
cord-019001-ralxw4ad	318	10	population	population	NN
cord-019001-ralxw4ad	318	11	[	[	-LRB-
cord-019001-ralxw4ad	318	12	223	223	CD
cord-019001-ralxw4ad	318	13	]	]	-RRB-
cord-019001-ralxw4ad	318	14	[	[	-LRB-
cord-019001-ralxw4ad	318	15	224	224	CD
cord-019001-ralxw4ad	318	16	]	]	-RRB-
cord-019001-ralxw4ad	318	17	[	[	-LRB-
cord-019001-ralxw4ad	318	18	225	225	CD
cord-019001-ralxw4ad	318	19	]	]	-RRB-
cord-019001-ralxw4ad	318	20	[	[	-LRB-
cord-019001-ralxw4ad	318	21	226	226	CD
cord-019001-ralxw4ad	318	22	]	]	-RRB-
cord-019001-ralxw4ad	318	23	;	;	:
cord-019001-ralxw4ad	318	24	however	however	RB
cord-019001-ralxw4ad	318	25	,	,	,
cord-019001-ralxw4ad	318	26	large	large	JJ
cord-019001-ralxw4ad	318	27	,	,	,
cord-019001-ralxw4ad	318	28	randomized	randomized	JJ
cord-019001-ralxw4ad	318	29	trails	trail	NNS
cord-019001-ralxw4ad	318	30	are	be	VBP
cord-019001-ralxw4ad	318	31	lacking	lack	VBG
cord-019001-ralxw4ad	318	32	.	.	.
cord-019001-ralxw4ad	319	1	One	one	CD
cord-019001-ralxw4ad	319	2	randomized	randomized	JJ
cord-019001-ralxw4ad	319	3	trial	trial	NN
cord-019001-ralxw4ad	319	4	did	do	VBD
cord-019001-ralxw4ad	319	5	demonstrate	demonstrate	VB
cord-019001-ralxw4ad	319	6	that	that	DT
cord-019001-ralxw4ad	319	7	inhaled	inhale	VBN
cord-019001-ralxw4ad	319	8	NO	no	DT
cord-019001-ralxw4ad	319	9	decreased	decrease	VBD
cord-019001-ralxw4ad	319	10	postoperative	postoperative	JJ
cord-019001-ralxw4ad	319	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	319	12	vascular	vascular	JJ
cord-019001-ralxw4ad	319	13	resistance	resistance	NN
cord-019001-ralxw4ad	319	14	,	,	,
cord-019001-ralxw4ad	319	15	the	the	DT
cord-019001-ralxw4ad	319	16	incidence	incidence	NN
cord-019001-ralxw4ad	319	17	of	of	IN
cord-019001-ralxw4ad	319	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	319	19	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	319	20	crises	crisis	NNS
cord-019001-ralxw4ad	319	21	,	,	,
cord-019001-ralxw4ad	319	22	and	and	CC
cord-019001-ralxw4ad	319	23	the	the	DT
cord-019001-ralxw4ad	319	24	days	day	NNS
cord-019001-ralxw4ad	319	25	of	of	IN
cord-019001-ralxw4ad	319	26	mechanical	mechanical	JJ
cord-019001-ralxw4ad	319	27	ventilation	ventilation	NN
cord-019001-ralxw4ad	319	28	compared	compare	VBN
cord-019001-ralxw4ad	319	29	with	with	IN
cord-019001-ralxw4ad	319	30	placebo	placebo	NN
cord-019001-ralxw4ad	319	31	[	[	-LRB-
cord-019001-ralxw4ad	319	32	226	226	CD
cord-019001-ralxw4ad	319	33	]	]	-RRB-
cord-019001-ralxw4ad	319	34	.	.	.
cord-019001-ralxw4ad	320	1	In	in	IN
cord-019001-ralxw4ad	320	2	patients	patient	NNS
cord-019001-ralxw4ad	320	3	with	with	IN
cord-019001-ralxw4ad	320	4	a	a	DT
cord-019001-ralxw4ad	320	5	history	history	NN
cord-019001-ralxw4ad	320	6	of	of	IN
cord-019001-ralxw4ad	320	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	320	8	venous	venous	JJ
cord-019001-ralxw4ad	320	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	320	10	(	(	-LRB-
cord-019001-ralxw4ad	320	11	total	total	JJ
cord-019001-ralxw4ad	320	12	anomalous	anomalous	JJ
cord-019001-ralxw4ad	320	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	320	14	venous	venous	JJ
cord-019001-ralxw4ad	320	15	return	return	NN
cord-019001-ralxw4ad	320	16	,	,	,
cord-019001-ralxw4ad	320	17	mitral	mitral	JJ
cord-019001-ralxw4ad	320	18	valve	valve	NN
cord-019001-ralxw4ad	320	19	disease	disease	NN
cord-019001-ralxw4ad	320	20	)	)	-RRB-
cord-019001-ralxw4ad	320	21	,	,	,
cord-019001-ralxw4ad	320	22	aggressive	aggressive	JJ
cord-019001-ralxw4ad	320	23	diuresis	diuresis	NN
cord-019001-ralxw4ad	320	24	may	may	MD
cord-019001-ralxw4ad	320	25	be	be	VB
cord-019001-ralxw4ad	320	26	helpful	helpful	JJ
cord-019001-ralxw4ad	320	27	because	because	IN
cord-019001-ralxw4ad	320	28	interstitial	interstitial	JJ
cord-019001-ralxw4ad	320	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	320	30	edema	edema	NN
cord-019001-ralxw4ad	320	31	may	may	MD
cord-019001-ralxw4ad	320	32	contribute	contribute	VB
cord-019001-ralxw4ad	320	33	signifi	signifi	NNP
cord-019001-ralxw4ad	320	34	cantly	cantly	RB
cord-019001-ralxw4ad	320	35	to	to	IN
cord-019001-ralxw4ad	320	36	elevations	elevation	NNS
cord-019001-ralxw4ad	320	37	in	in	IN
cord-019001-ralxw4ad	320	38	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	320	39	vascular	vascular	JJ
cord-019001-ralxw4ad	320	40	resistance	resistance	NN
cord-019001-ralxw4ad	320	41	.	.	.
cord-019001-ralxw4ad	321	1	Therapies	therapy	NNS
cord-019001-ralxw4ad	321	2	that	that	WDT
cord-019001-ralxw4ad	321	3	maintain	maintain	VBP
cord-019001-ralxw4ad	321	4	an	an	DT
cord-019001-ralxw4ad	321	5	adequate	adequate	JJ
cord-019001-ralxw4ad	321	6	cardiac	cardiac	JJ
cord-019001-ralxw4ad	321	7	output	output	NN
cord-019001-ralxw4ad	321	8	in	in	IN
cord-019001-ralxw4ad	321	9	this	this	DT
cord-019001-ralxw4ad	321	10	patient	patient	JJ
cord-019001-ralxw4ad	321	11	population	population	NN
cord-019001-ralxw4ad	321	12	are	be	VBP
cord-019001-ralxw4ad	321	13	not	not	RB
cord-019001-ralxw4ad	321	14	dissimilar	dissimilar	JJ
cord-019001-ralxw4ad	321	15	to	to	IN
cord-019001-ralxw4ad	321	16	therapies	therapy	NNS
cord-019001-ralxw4ad	321	17	utilized	utilize	VBN
cord-019001-ralxw4ad	321	18	in	in	IN
cord-019001-ralxw4ad	321	19	other	other	JJ
cord-019001-ralxw4ad	321	20	patient	patient	JJ
cord-019001-ralxw4ad	321	21	populations	population	NNS
cord-019001-ralxw4ad	321	22	,	,	,
cord-019001-ralxw4ad	321	23	with	with	IN
cord-019001-ralxw4ad	321	24	the	the	DT
cord-019001-ralxw4ad	321	25	exception	exception	NN
cord-019001-ralxw4ad	321	26	of	of	IN
cord-019001-ralxw4ad	321	27	the	the	DT
cord-019001-ralxw4ad	321	28	particular	particular	JJ
cord-019001-ralxw4ad	321	29	emphasis	emphasis	NN
cord-019001-ralxw4ad	321	30	placed	place	VBN
cord-019001-ralxw4ad	321	31	on	on	IN
cord-019001-ralxw4ad	321	32	right	right	JJ
cord-019001-ralxw4ad	321	33	ventricular	ventricular	JJ
cord-019001-ralxw4ad	321	34	afterload	afterload	NN
cord-019001-ralxw4ad	321	35	reduction	reduction	NN
cord-019001-ralxw4ad	321	36	and	and	CC
cord-019001-ralxw4ad	321	37	support	support	NN
cord-019001-ralxw4ad	321	38	.	.	.
cord-019001-ralxw4ad	322	1	It	-PRON-	PRP
cord-019001-ralxw4ad	322	2	is	be	VBZ
cord-019001-ralxw4ad	322	3	noteworthy	noteworthy	JJ
cord-019001-ralxw4ad	322	4	that	that	IN
cord-019001-ralxw4ad	322	5	patients	patient	NNS
cord-019001-ralxw4ad	322	6	with	with	IN
cord-019001-ralxw4ad	322	7	a	a	DT
cord-019001-ralxw4ad	322	8	poorly	poorly	RB
cord-019001-ralxw4ad	322	9	compliant	compliant	JJ
cord-019001-ralxw4ad	322	10	right	right	JJ
cord-019001-ralxw4ad	322	11	ventricle	ventricle	NN
cord-019001-ralxw4ad	322	12	or	or	CC
cord-019001-ralxw4ad	322	13	with	with	IN
cord-019001-ralxw4ad	322	14	increased	increase	VBN
cord-019001-ralxw4ad	322	15	right	right	JJ
cord-019001-ralxw4ad	322	16	ventricular	ventricular	JJ
cord-019001-ralxw4ad	322	17	afterload	afterload	NN
cord-019001-ralxw4ad	322	18	may	may	MD
cord-019001-ralxw4ad	322	19	require	require	VB
cord-019001-ralxw4ad	322	20	elevated	elevated	JJ
cord-019001-ralxw4ad	322	21	central	central	JJ
cord-019001-ralxw4ad	322	22	venous	venous	JJ
cord-019001-ralxw4ad	322	23	pressures	pressure	NNS
cord-019001-ralxw4ad	322	24	to	to	TO
cord-019001-ralxw4ad	322	25	maintain	maintain	VB
cord-019001-ralxw4ad	322	26	an	an	DT
cord-019001-ralxw4ad	322	27	adequate	adequate	JJ
cord-019001-ralxw4ad	322	28	preload	preload	NN
cord-019001-ralxw4ad	322	29	.	.	.
cord-019001-ralxw4ad	323	1	In	in	IN
cord-019001-ralxw4ad	323	2	addition	addition	NN
cord-019001-ralxw4ad	323	3	,	,	,
cord-019001-ralxw4ad	323	4	the	the	DT
cord-019001-ralxw4ad	323	5	use	use	NN
cord-019001-ralxw4ad	323	6	of	of	IN
cord-019001-ralxw4ad	323	7	inotropic	inotropic	NNP
cord-019001-ralxw4ad	323	8	agents	agent	NNS
cord-019001-ralxw4ad	323	9	with	with	IN
cord-019001-ralxw4ad	323	10	signifi	signifi	NNP
cord-019001-ralxw4ad	323	11	ca	can	MD
cord-019001-ralxw4ad	323	12	nt	not	RB
cord-019001-ralxw4ad	323	13	α	α	NN
cord-019001-ralxw4ad	323	14	1	1	CD
cord-019001-ralxw4ad	323	15	-adrenergic	-adrenergic	JJ
cord-019001-ralxw4ad	323	16	effect	effect	NN
cord-019001-ralxw4ad	323	17	should	should	MD
cord-019001-ralxw4ad	323	18	be	be	VB
cord-019001-ralxw4ad	323	19	minimized	minimize	VBN
cord-019001-ralxw4ad	323	20	to	to	TO
cord-019001-ralxw4ad	323	21	avoid	avoid	VB
cord-019001-ralxw4ad	323	22	the	the	DT
cord-019001-ralxw4ad	323	23	associated	associate	VBN
cord-019001-ralxw4ad	323	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	323	25	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	323	26	.	.	.
cord-019001-ralxw4ad	324	1	Agents	agent	NNS
cord-019001-ralxw4ad	324	2	such	such	JJ
cord-019001-ralxw4ad	324	3	as	as	IN
cord-019001-ralxw4ad	324	4	dobutamine	dobutamine	NNP
cord-019001-ralxw4ad	324	5	,	,	,
cord-019001-ralxw4ad	324	6	milrinone	milrinone	NNP
cord-019001-ralxw4ad	324	7	,	,	,
cord-019001-ralxw4ad	324	8	and	and	CC
cord-019001-ralxw4ad	324	9	dopamine	dopamine	NN
cord-019001-ralxw4ad	324	10	are	be	VBP
cord-019001-ralxw4ad	324	11	routinely	routinely	RB
cord-019001-ralxw4ad	324	12	utilized	utilize	VBN
cord-019001-ralxw4ad	324	13	.	.	.
cord-019001-ralxw4ad	325	1	The	the	DT
cord-019001-ralxw4ad	325	2	use	use	NN
cord-019001-ralxw4ad	325	3	of	of	IN
cord-019001-ralxw4ad	325	4	high	high	JJ
cord-019001-ralxw4ad	325	5	levels	level	NNS
cord-019001-ralxw4ad	325	6	of	of	IN
cord-019001-ralxw4ad	325	7	positive	positive	JJ
cord-019001-ralxw4ad	325	8	end	end	NN
cord-019001-ralxw4ad	325	9	-	-	HYPH
cord-019001-ralxw4ad	325	10	expiratory	expiratory	NN
cord-019001-ralxw4ad	325	11	pressure	pressure	NN
cord-019001-ralxw4ad	325	12	(	(	-LRB-
cord-019001-ralxw4ad	325	13	PEEP	peep	NN
cord-019001-ralxw4ad	325	14	)	)	-RRB-
cord-019001-ralxw4ad	325	15	is	be	VBZ
cord-019001-ralxw4ad	325	16	somewhat	somewhat	RB
cord-019001-ralxw4ad	325	17	controversial	controversial	JJ
cord-019001-ralxw4ad	325	18	.	.	.
cord-019001-ralxw4ad	326	1	Mechanical	mechanical	JJ
cord-019001-ralxw4ad	326	2	hyperventilation	hyperventilation	NN
cord-019001-ralxw4ad	326	3	with	with	IN
cord-019001-ralxw4ad	326	4	high	high	JJ
cord-019001-ralxw4ad	326	5	PEEP	peep	NN
cord-019001-ralxw4ad	326	6	increases	increase	VBZ
cord-019001-ralxw4ad	326	7	intrathoracic	intrathoracic	JJ
cord-019001-ralxw4ad	326	8	pressure	pressure	NN
cord-019001-ralxw4ad	326	9	and	and	CC
cord-019001-ralxw4ad	326	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	326	11	vascular	vascular	JJ
cord-019001-ralxw4ad	326	12	resistance	resistance	NN
cord-019001-ralxw4ad	326	13	[	[	-LRB-
cord-019001-ralxw4ad	326	14	85	85	CD
cord-019001-ralxw4ad	326	15	,	,	,
cord-019001-ralxw4ad	326	16	115	115	CD
cord-019001-ralxw4ad	326	17	]	]	-RRB-
cord-019001-ralxw4ad	326	18	.	.	.
cord-019001-ralxw4ad	327	1	This	this	DT
cord-019001-ralxw4ad	327	2	therapy	therapy	NN
cord-019001-ralxw4ad	327	3	should	should	MD
cord-019001-ralxw4ad	327	4	be	be	VB
cord-019001-ralxw4ad	327	5	avoided	avoid	VBN
cord-019001-ralxw4ad	327	6	if	if	IN
cord-019001-ralxw4ad	327	7	adequate	adequate	JJ
cord-019001-ralxw4ad	327	8	systemic	systemic	JJ
cord-019001-ralxw4ad	327	9	arterial	arterial	JJ
cord-019001-ralxw4ad	327	10	saturation	saturation	NN
cord-019001-ralxw4ad	327	11	can	can	MD
cord-019001-ralxw4ad	327	12	be	be	VB
cord-019001-ralxw4ad	327	13	achieved	achieve	VBN
cord-019001-ralxw4ad	327	14	by	by	IN
cord-019001-ralxw4ad	327	15	other	other	JJ
cord-019001-ralxw4ad	327	16	means	mean	NNS
cord-019001-ralxw4ad	327	17	.	.	.
cord-019001-ralxw4ad	328	1	However	however	RB
cord-019001-ralxw4ad	328	2	,	,	,
cord-019001-ralxw4ad	328	3	at	at	IN
cord-019001-ralxw4ad	328	4	low	low	JJ
cord-019001-ralxw4ad	328	5	lung	lung	NN
cord-019001-ralxw4ad	328	6	volumes	volume	NNS
cord-019001-ralxw4ad	328	7	,	,	,
cord-019001-ralxw4ad	328	8	the	the	DT
cord-019001-ralxw4ad	328	9	use	use	NN
cord-019001-ralxw4ad	328	10	of	of	IN
cord-019001-ralxw4ad	328	11	PEEP	PEEP	NNP
cord-019001-ralxw4ad	328	12	may	may	MD
cord-019001-ralxw4ad	328	13	increase	increase	VB
cord-019001-ralxw4ad	328	14	lung	lung	NN
cord-019001-ralxw4ad	328	15	volume	volume	NN
cord-019001-ralxw4ad	328	16	 	 	_SP
cord-019001-ralxw4ad	328	17	Until	until	IN
cord-019001-ralxw4ad	328	18	very	very	RB
cord-019001-ralxw4ad	328	19	recently	recently	RB
cord-019001-ralxw4ad	328	20	,	,	,
cord-019001-ralxw4ad	328	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	328	22	arterial	arterial	JJ
cord-019001-ralxw4ad	328	23	hypertension	hypertension	NN
cord-019001-ralxw4ad	328	24	of	of	IN
cord-019001-ralxw4ad	328	25	unknown	unknown	JJ
cord-019001-ralxw4ad	328	26	etiology	etiology	NN
cord-019001-ralxw4ad	328	27	was	be	VBD
cord-019001-ralxw4ad	328	28	termed	term	VBN
cord-019001-ralxw4ad	328	29	primary	primary	JJ
cord-019001-ralxw4ad	328	30	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	328	31	hypertension	hypertension	NN
cord-019001-ralxw4ad	328	32	.	.	.
cord-019001-ralxw4ad	329	1	However	however	RB
cord-019001-ralxw4ad	329	2	,	,	,
cord-019001-ralxw4ad	329	3	recent	recent	JJ
cord-019001-ralxw4ad	329	4	evidence	evidence	NN
cord-019001-ralxw4ad	329	5	indicates	indicate	VBZ
cord-019001-ralxw4ad	329	6	a	a	DT
cord-019001-ralxw4ad	329	7	genetic	genetic	JJ
cord-019001-ralxw4ad	329	8	disposition	disposition	NN
cord-019001-ralxw4ad	329	9	in	in	IN
cord-019001-ralxw4ad	329	10	a	a	DT
cord-019001-ralxw4ad	329	11	subset	subset	NN
cord-019001-ralxw4ad	329	12	of	of	IN
cord-019001-ralxw4ad	329	13	patients	patient	NNS
cord-019001-ralxw4ad	329	14	with	with	IN
cord-019001-ralxw4ad	329	15	primary	primary	JJ
cord-019001-ralxw4ad	329	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	329	17	hypertension	hypertension	NN
cord-019001-ralxw4ad	329	18	,	,	,
cord-019001-ralxw4ad	329	19	and	and	CC
cord-019001-ralxw4ad	329	20	a	a	DT
cord-019001-ralxw4ad	329	21	number	number	NN
cord-019001-ralxw4ad	329	22	of	of	IN
cord-019001-ralxw4ad	329	23	diseases	disease	NNS
cord-019001-ralxw4ad	329	24	that	that	WDT
cord-019001-ralxw4ad	329	25	lead	lead	VBP
cord-019001-ralxw4ad	329	26	to	to	IN
cord-019001-ralxw4ad	329	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	329	28	arterial	arterial	JJ
cord-019001-ralxw4ad	329	29	hypertension	hypertension	NN
cord-019001-ralxw4ad	329	30	with	with	IN
cord-019001-ralxw4ad	329	31	similar	similar	JJ
cord-019001-ralxw4ad	329	32	histological	histological	JJ
cord-019001-ralxw4ad	329	33	and	and	CC
cord-019001-ralxw4ad	329	34	pathophysiologic	pathophysiologic	NN
cord-019001-ralxw4ad	329	35	features	feature	NNS
cord-019001-ralxw4ad	329	36	have	have	VBP
cord-019001-ralxw4ad	329	37	been	be	VBN
cord-019001-ralxw4ad	329	38	uncovered	uncover	VBN
cord-019001-ralxw4ad	329	39	[	[	-LRB-
cord-019001-ralxw4ad	329	40	102	102	CD
cord-019001-ralxw4ad	329	41	]	]	-RRB-
cord-019001-ralxw4ad	329	42	[	[	-LRB-
cord-019001-ralxw4ad	329	43	103	103	CD
cord-019001-ralxw4ad	329	44	]	]	-RRB-
cord-019001-ralxw4ad	329	45	[	[	-LRB-
cord-019001-ralxw4ad	329	46	104	104	CD
cord-019001-ralxw4ad	329	47	]	]	-RRB-
cord-019001-ralxw4ad	329	48	[	[	-LRB-
cord-019001-ralxw4ad	329	49	105	105	CD
cord-019001-ralxw4ad	329	50	]	]	-RRB-
cord-019001-ralxw4ad	329	51	.	.	.
cord-019001-ralxw4ad	330	1	Thus	thus	RB
cord-019001-ralxw4ad	330	2	,	,	,
cord-019001-ralxw4ad	330	3	at	at	IN
cord-019001-ralxw4ad	330	4	the	the	DT
cord-019001-ralxw4ad	330	5	2003	2003	CD
cord-019001-ralxw4ad	330	6	Third	Third	NNP
cord-019001-ralxw4ad	330	7	World	World	NNP
cord-019001-ralxw4ad	330	8	Symposium	Symposium	NNP
cord-019001-ralxw4ad	330	9	on	on	IN
cord-019001-ralxw4ad	330	10	Pulmonary	Pulmonary	NNP
cord-019001-ralxw4ad	330	11	Arterial	Arterial	NNP
cord-019001-ralxw4ad	330	12	Hypertension	Hypertension	NNP
cord-019001-ralxw4ad	330	13	,	,	,
cord-019001-ralxw4ad	330	14	a	a	DT
cord-019001-ralxw4ad	330	15	new	new	JJ
cord-019001-ralxw4ad	330	16	classifi	classifi	NN
cord-019001-ralxw4ad	330	17	cation	cation	NN
cord-019001-ralxw4ad	330	18	was	be	VBD
cord-019001-ralxw4ad	330	19	proposed	propose	VBN
cord-019001-ralxw4ad	330	20	to	to	TO
cord-019001-ralxw4ad	330	21	further	further	RB
cord-019001-ralxw4ad	330	22	classify	classify	VB
cord-019001-ralxw4ad	330	23	primary	primary	JJ
cord-019001-ralxw4ad	330	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	330	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	330	26	into	into	IN
cord-019001-ralxw4ad	330	27	the	the	DT
cord-019001-ralxw4ad	330	28	following	follow	VBG
cord-019001-ralxw4ad	330	29	subgroups	subgroup	NNS
cord-019001-ralxw4ad	330	30	:	:	:
cord-019001-ralxw4ad	330	31	(	(	-LRB-
cord-019001-ralxw4ad	330	32	1	1	LS
cord-019001-ralxw4ad	330	33	)	)	-RRB-
cord-019001-ralxw4ad	330	34	idiopathic	idiopathic	JJ
cord-019001-ralxw4ad	330	35	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	330	36	arterial	arterial	JJ
cord-019001-ralxw4ad	330	37	hypertension	hypertension	NN
cord-019001-ralxw4ad	330	38	(	(	-LRB-
cord-019001-ralxw4ad	330	39	IPAH	IPAH	NNP
cord-019001-ralxw4ad	330	40	)	)	-RRB-
cord-019001-ralxw4ad	330	41	,	,	,
cord-019001-ralxw4ad	330	42	(	(	-LRB-
cord-019001-ralxw4ad	330	43	2	2	LS
cord-019001-ralxw4ad	330	44	)	)	-RRB-
cord-019001-ralxw4ad	330	45	familial	familial	JJ
cord-019001-ralxw4ad	330	46	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	330	47	arterial	arterial	JJ
cord-019001-ralxw4ad	330	48	hypertension	hypertension	NN
cord-019001-ralxw4ad	330	49	(	(	-LRB-
cord-019001-ralxw4ad	330	50	FPAH	FPAH	NNP
cord-019001-ralxw4ad	330	51	)	)	-RRB-
cord-019001-ralxw4ad	330	52	,	,	,
cord-019001-ralxw4ad	330	53	and	and	CC
cord-019001-ralxw4ad	330	54	(	(	-LRB-
cord-019001-ralxw4ad	330	55	3	3	LS
cord-019001-ralxw4ad	330	56	)	)	-RRB-
cord-019001-ralxw4ad	330	57	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	330	58	arterial	arterial	JJ
cord-019001-ralxw4ad	330	59	hypertension	hypertension	NN
cord-019001-ralxw4ad	330	60	related	relate	VBN
cord-019001-ralxw4ad	330	61	to	to	IN
cord-019001-ralxw4ad	330	62	risk	risk	NN
cord-019001-ralxw4ad	330	63	factors	factor	NNS
cord-019001-ralxw4ad	330	64	or	or	CC
cord-019001-ralxw4ad	330	65	associated	associate	VBN
cord-019001-ralxw4ad	330	66	conditions	condition	NNS
cord-019001-ralxw4ad	330	67	(	(	-LRB-
cord-019001-ralxw4ad	330	68	APAH	APAH	NNP
cord-019001-ralxw4ad	330	69	)	)	-RRB-
cord-019001-ralxw4ad	330	70	[	[	-LRB-
cord-019001-ralxw4ad	330	71	227	227	CD
cord-019001-ralxw4ad	330	72	]	]	-RRB-
cord-019001-ralxw4ad	330	73	.	.	.
cord-019001-ralxw4ad	331	1	Unfortunately	unfortunately	RB
cord-019001-ralxw4ad	331	2	,	,	,
cord-019001-ralxw4ad	331	3	mortality	mortality	NN
cord-019001-ralxw4ad	331	4	from	from	IN
cord-019001-ralxw4ad	331	5	primary	primary	JJ
cord-019001-ralxw4ad	331	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	331	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	331	8	remains	remain	VBZ
cord-019001-ralxw4ad	331	9	high	high	JJ
cord-019001-ralxw4ad	331	10	and	and	CC
cord-019001-ralxw4ad	331	11	may	may	MD
cord-019001-ralxw4ad	331	12	be	be	VB
cord-019001-ralxw4ad	331	13	higher	high	JJR
cord-019001-ralxw4ad	331	14	for	for	IN
cord-019001-ralxw4ad	331	15	children	child	NNS
cord-019001-ralxw4ad	331	16	than	than	IN
cord-019001-ralxw4ad	331	17	adults	adult	NNS
cord-019001-ralxw4ad	331	18	.	.	.
cord-019001-ralxw4ad	332	1	In	in	IN
cord-019001-ralxw4ad	332	2	fact	fact	NN
cord-019001-ralxw4ad	332	3	,	,	,
cord-019001-ralxw4ad	332	4	the	the	DT
cord-019001-ralxw4ad	332	5	Primary	Primary	NNP
cord-019001-ralxw4ad	332	6	Pulmonary	Pulmonary	NNP
cord-019001-ralxw4ad	332	7	Hypertension	Hypertension	NNP
cord-019001-ralxw4ad	332	8	National	National	NNP
cord-019001-ralxw4ad	332	9	Institutes	Institutes	NNPS
cord-019001-ralxw4ad	332	10	of	of	IN
cord-019001-ralxw4ad	332	11	Health	Health	NNP
cord-019001-ralxw4ad	332	12	Registry	Registry	NNP
cord-019001-ralxw4ad	332	13	reports	report	VBZ
cord-019001-ralxw4ad	332	14	a	a	DT
cord-019001-ralxw4ad	332	15	median	median	JJ
cord-019001-ralxw4ad	332	16	survival	survival	NN
cord-019001-ralxw4ad	332	17	of	of	IN
cord-019001-ralxw4ad	332	18	only	only	RB
cord-019001-ralxw4ad	332	19	10	10	CD
cord-019001-ralxw4ad	332	20	months	month	NNS
cord-019001-ralxw4ad	332	21	for	for	IN
cord-019001-ralxw4ad	332	22	pediatric	pediatric	JJ
cord-019001-ralxw4ad	332	23	patients	patient	NNS
cord-019001-ralxw4ad	332	24	[	[	-LRB-
cord-019001-ralxw4ad	332	25	228	228	CD
cord-019001-ralxw4ad	332	26	]	]	-RRB-
cord-019001-ralxw4ad	332	27	.	.	.
cord-019001-ralxw4ad	333	1	However	however	RB
cord-019001-ralxw4ad	333	2	,	,	,
cord-019001-ralxw4ad	333	3	recent	recent	JJ
cord-019001-ralxw4ad	333	4	data	datum	NNS
cord-019001-ralxw4ad	333	5	suggest	suggest	VBP
cord-019001-ralxw4ad	333	6	that	that	IN
cord-019001-ralxw4ad	333	7	pediatric	pediatric	JJ
cord-019001-ralxw4ad	333	8	patients	patient	NNS
cord-019001-ralxw4ad	333	9	may	may	MD
cord-019001-ralxw4ad	333	10	respond	respond	VB
cord-019001-ralxw4ad	333	11	differently	differently	RB
cord-019001-ralxw4ad	333	12	than	than	IN
cord-019001-ralxw4ad	333	13	adults	adult	NNS
cord-019001-ralxw4ad	333	14	to	to	IN
cord-019001-ralxw4ad	333	15	new	new	JJ
cord-019001-ralxw4ad	333	16	therapies	therapy	NNS
cord-019001-ralxw4ad	333	17	and	and	CC
cord-019001-ralxw4ad	333	18	that	that	IN
cord-019001-ralxw4ad	333	19	these	these	DT
cord-019001-ralxw4ad	333	20	differences	difference	NNS
cord-019001-ralxw4ad	333	21	may	may	MD
cord-019001-ralxw4ad	333	22	portend	portend	VB
cord-019001-ralxw4ad	333	23	a	a	DT
cord-019001-ralxw4ad	333	24	better	well	JJR
cord-019001-ralxw4ad	333	25	outcome	outcome	NN
cord-019001-ralxw4ad	333	26	in	in	IN
cord-019001-ralxw4ad	333	27	younger	young	JJR
cord-019001-ralxw4ad	333	28	patients	patient	NNS
cord-019001-ralxw4ad	333	29	[	[	-LRB-
cord-019001-ralxw4ad	333	30	229	229	CD
cord-019001-ralxw4ad	333	31	,	,	,
cord-019001-ralxw4ad	333	32	230	230	CD
cord-019001-ralxw4ad	333	33	]	]	-RRB-
cord-019001-ralxw4ad	333	34	.	.	.
cord-019001-ralxw4ad	334	1	The	the	DT
cord-019001-ralxw4ad	334	2	frequency	frequency	NN
cord-019001-ralxw4ad	334	3	of	of	IN
cord-019001-ralxw4ad	334	4	primary	primary	JJ
cord-019001-ralxw4ad	334	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	334	6	hypertension	hypertension	NN
cord-019001-ralxw4ad	334	7	in	in	IN
cord-019001-ralxw4ad	334	8	pediatric	pediatric	JJ
cord-019001-ralxw4ad	334	9	patients	patient	NNS
cord-019001-ralxw4ad	334	10	is	be	VBZ
cord-019001-ralxw4ad	334	11	not	not	RB
cord-019001-ralxw4ad	334	12	known	know	VBN
cord-019001-ralxw4ad	334	13	,	,	,
cord-019001-ralxw4ad	334	14	but	but	CC
cord-019001-ralxw4ad	334	15	it	-PRON-	PRP
cord-019001-ralxw4ad	334	16	appears	appear	VBZ
cord-019001-ralxw4ad	334	17	that	that	IN
cord-019001-ralxw4ad	334	18	the	the	DT
cord-019001-ralxw4ad	334	19	number	number	NN
cord-019001-ralxw4ad	334	20	of	of	IN
cord-019001-ralxw4ad	334	21	confi	confi	NN
cord-019001-ralxw4ad	334	22	rmed	rme	VBN
cord-019001-ralxw4ad	334	23	cases	case	NNS
cord-019001-ralxw4ad	334	24	is	be	VBZ
cord-019001-ralxw4ad	334	25	increasing	increase	VBG
cord-019001-ralxw4ad	334	26	.	.	.
cord-019001-ralxw4ad	335	1	The	the	DT
cord-019001-ralxw4ad	335	2	incidence	incidence	NN
cord-019001-ralxw4ad	335	3	is	be	VBZ
cord-019001-ralxw4ad	335	4	slightly	slightly	RB
cord-019001-ralxw4ad	335	5	increased	increase	VBN
cord-019001-ralxw4ad	335	6	in	in	IN
cord-019001-ralxw4ad	335	7	females	female	NNS
cord-019001-ralxw4ad	335	8	[	[	-LRB-
cord-019001-ralxw4ad	335	9	231	231	CD
cord-019001-ralxw4ad	335	10	]	]	-RRB-
cord-019001-ralxw4ad	335	11	.	.	.
cord-019001-ralxw4ad	336	1	The	the	DT
cord-019001-ralxw4ad	336	2	most	most	RBS
cord-019001-ralxw4ad	336	3	common	common	JJ
cord-019001-ralxw4ad	336	4	causes	cause	NNS
cord-019001-ralxw4ad	336	5	of	of	IN
cord-019001-ralxw4ad	336	6	death	death	NN
cord-019001-ralxw4ad	336	7	in	in	IN
cord-019001-ralxw4ad	336	8	children	child	NNS
cord-019001-ralxw4ad	336	9	with	with	IN
cord-019001-ralxw4ad	336	10	primary	primary	JJ
cord-019001-ralxw4ad	336	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	336	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	336	13	are	be	VBP
cord-019001-ralxw4ad	336	14	right	right	JJ
cord-019001-ralxw4ad	336	15	ventricular	ventricular	JJ
cord-019001-ralxw4ad	336	16	failure	failure	NN
cord-019001-ralxw4ad	336	17	and	and	CC
cord-019001-ralxw4ad	336	18	sudden	sudden	JJ
cord-019001-ralxw4ad	336	19	death	death	NN
cord-019001-ralxw4ad	336	20	,	,	,
cord-019001-ralxw4ad	336	21	which	which	WDT
cord-019001-ralxw4ad	336	22	may	may	MD
cord-019001-ralxw4ad	336	23	be	be	VB
cord-019001-ralxw4ad	336	24	related	relate	VBN
cord-019001-ralxw4ad	336	25	to	to	IN
cord-019001-ralxw4ad	336	26	malignant	malignant	JJ
cord-019001-ralxw4ad	336	27	cardiac	cardiac	JJ
cord-019001-ralxw4ad	336	28	arrhythmias	arrhythmia	NNS
cord-019001-ralxw4ad	336	29	,	,	,
cord-019001-ralxw4ad	336	30	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	336	31	emboli	emboli	NN
cord-019001-ralxw4ad	336	32	,	,	,
cord-019001-ralxw4ad	336	33	or	or	CC
cord-019001-ralxw4ad	336	34	acute	acute	JJ
cord-019001-ralxw4ad	336	35	right	right	JJ
cord-019001-ralxw4ad	336	36	ventricular	ventricular	JJ
cord-019001-ralxw4ad	336	37	ischemia	ischemia	NN
cord-019001-ralxw4ad	336	38	[	[	-LRB-
cord-019001-ralxw4ad	336	39	228	228	CD
cord-019001-ralxw4ad	336	40	]	]	-RRB-
cord-019001-ralxw4ad	336	41	.	.	.
cord-019001-ralxw4ad	337	1	Physicians	physician	NNS
cord-019001-ralxw4ad	337	2	caring	care	VBG
cord-019001-ralxw4ad	337	3	for	for	IN
cord-019001-ralxw4ad	337	4	children	child	NNS
cord-019001-ralxw4ad	337	5	in	in	IN
cord-019001-ralxw4ad	337	6	an	an	DT
cord-019001-ralxw4ad	337	7	intensive	intensive	JJ
cord-019001-ralxw4ad	337	8	care	care	NN
cord-019001-ralxw4ad	337	9	unit	unit	NN
cord-019001-ralxw4ad	337	10	setting	setting	NN
cord-019001-ralxw4ad	337	11	must	must	MD
cord-019001-ralxw4ad	337	12	be	be	VB
cord-019001-ralxw4ad	337	13	cognizant	cognizant	JJ
cord-019001-ralxw4ad	337	14	of	of	IN
cord-019001-ralxw4ad	337	15	this	this	DT
cord-019001-ralxw4ad	337	16	disorder	disorder	NN
cord-019001-ralxw4ad	337	17	,	,	,
cord-019001-ralxw4ad	337	18	albeit	albeit	IN
cord-019001-ralxw4ad	337	19	rare	rare	JJ
cord-019001-ralxw4ad	337	20	,	,	,
cord-019001-ralxw4ad	337	21	because	because	IN
cord-019001-ralxw4ad	337	22	relatively	relatively	RB
cord-019001-ralxw4ad	337	23	benign	benign	JJ
cord-019001-ralxw4ad	337	24	disease	disease	NN
cord-019001-ralxw4ad	337	25	processes	process	NNS
cord-019001-ralxw4ad	337	26	,	,	,
cord-019001-ralxw4ad	337	27	such	such	JJ
cord-019001-ralxw4ad	337	28	as	as	IN
cord-019001-ralxw4ad	337	29	pneumonia	pneumonia	NN
cord-019001-ralxw4ad	337	30	,	,	,
cord-019001-ralxw4ad	337	31	can	can	MD
cord-019001-ralxw4ad	337	32	be	be	VB
cord-019001-ralxw4ad	337	33	life	life	NN
cord-019001-ralxw4ad	337	34	threatening	threaten	VBG
cord-019001-ralxw4ad	337	35	for	for	IN
cord-019001-ralxw4ad	337	36	children	child	NNS
cord-019001-ralxw4ad	337	37	with	with	IN
cord-019001-ralxw4ad	337	38	primary	primary	JJ
cord-019001-ralxw4ad	337	39	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	337	40	hypertension	hypertension	NN
cord-019001-ralxw4ad	337	41	,	,	,
cord-019001-ralxw4ad	337	42	which	which	WDT
cord-019001-ralxw4ad	337	43	may	may	MD
cord-019001-ralxw4ad	337	44	not	not	RB
cord-019001-ralxw4ad	337	45	have	have	VB
cord-019001-ralxw4ad	337	46	been	be	VBN
cord-019001-ralxw4ad	337	47	previously	previously	RB
cord-019001-ralxw4ad	337	48	identifi	identifi	VBN
cord-019001-ralxw4ad	337	49	ed	ed	NN
cord-019001-ralxw4ad	337	50	.	.	.
cord-019001-ralxw4ad	338	1	As	as	IN
cord-019001-ralxw4ad	338	2	opposed	oppose	VBN
cord-019001-ralxw4ad	338	3	to	to	IN
cord-019001-ralxw4ad	338	4	adults	adult	NNS
cord-019001-ralxw4ad	338	5	with	with	IN
cord-019001-ralxw4ad	338	6	primary	primary	JJ
cord-019001-ralxw4ad	338	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	338	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	338	9	,	,	,
cord-019001-ralxw4ad	338	10	who	who	WP
cord-019001-ralxw4ad	338	11	often	often	RB
cord-019001-ralxw4ad	338	12	have	have	VBP
cord-019001-ralxw4ad	338	13	severe	severe	JJ
cord-019001-ralxw4ad	338	14	plexiform	plexiform	NN
cord-019001-ralxw4ad	338	15	lesions	lesion	NNS
cord-019001-ralxw4ad	338	16	resulting	result	VBG
cord-019001-ralxw4ad	338	17	in	in	IN
cord-019001-ralxw4ad	338	18	relatively	relatively	RB
cord-019001-ralxw4ad	338	19	fi	fi	NN
cord-019001-ralxw4ad	338	20	xed	xed	FW
cord-019001-ralxw4ad	338	21	vascular	vascular	JJ
cord-019001-ralxw4ad	338	22	changes	change	NNS
cord-019001-ralxw4ad	338	23	,	,	,
cord-019001-ralxw4ad	338	24	children	child	NNS
cord-019001-ralxw4ad	338	25	display	display	VBP
cord-019001-ralxw4ad	338	26	greater	great	JJR
cord-019001-ralxw4ad	338	27	medial	medial	JJ
cord-019001-ralxw4ad	338	28	hypertrophy	hypertrophy	NN
cord-019001-ralxw4ad	338	29	with	with	IN
cord-019001-ralxw4ad	338	30	less	less	RBR
cord-019001-ralxw4ad	338	31	intimal	intimal	JJ
cord-019001-ralxw4ad	338	32	fi	fi	NN
cord-019001-ralxw4ad	338	33	brosis	brosis	NN
cord-019001-ralxw4ad	338	34	and	and	CC
cord-019001-ralxw4ad	338	35	fewer	few	JJR
cord-019001-ralxw4ad	338	36	plexiform	plexiform	NN
cord-019001-ralxw4ad	338	37	lesions	lesion	NNS
cord-019001-ralxw4ad	338	38	[	[	-LRB-
cord-019001-ralxw4ad	338	39	187	187	CD
cord-019001-ralxw4ad	338	40	,	,	,
cord-019001-ralxw4ad	338	41	229	229	CD
cord-019001-ralxw4ad	338	42	]	]	-RRB-
cord-019001-ralxw4ad	338	43	.	.	.
cord-019001-ralxw4ad	339	1	In	in	IN
cord-019001-ralxw4ad	339	2	addition	addition	NN
cord-019001-ralxw4ad	339	3	,	,	,
cord-019001-ralxw4ad	339	4	pediatric	pediatric	JJ
cord-019001-ralxw4ad	339	5	patients	patient	NNS
cord-019001-ralxw4ad	339	6	have	have	VBP
cord-019001-ralxw4ad	339	7	a	a	DT
cord-019001-ralxw4ad	339	8	decreased	decrease	VBN
cord-019001-ralxw4ad	339	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	339	10	arterial	arterial	JJ
cord-019001-ralxw4ad	339	11	number	number	NN
cord-019001-ralxw4ad	339	12	and	and	CC
cord-019001-ralxw4ad	339	13	increased	increase	VBN
cord-019001-ralxw4ad	339	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	339	15	vascular	vascular	JJ
cord-019001-ralxw4ad	339	16	reactivity	reactivity	NN
cord-019001-ralxw4ad	339	17	compared	compare	VBN
cord-019001-ralxw4ad	339	18	with	with	IN
cord-019001-ralxw4ad	339	19	adult	adult	NN
cord-019001-ralxw4ad	339	20	patients	patient	NNS
cord-019001-ralxw4ad	339	21	.	.	.
cord-019001-ralxw4ad	340	1	The	the	DT
cord-019001-ralxw4ad	340	2	molecular	molecular	JJ
cord-019001-ralxw4ad	340	3	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	340	4	underlying	underlie	VBG
cord-019001-ralxw4ad	340	5	primary	primary	JJ
cord-019001-ralxw4ad	340	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	340	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	340	8	remain	remain	VBP
cord-019001-ralxw4ad	340	9	speculative	speculative	JJ
cord-019001-ralxw4ad	340	10	;	;	:
cord-019001-ralxw4ad	340	11	however	however	RB
cord-019001-ralxw4ad	340	12	,	,	,
cord-019001-ralxw4ad	340	13	studies	study	NNS
cord-019001-ralxw4ad	340	14	suggest	suggest	VBP
cord-019001-ralxw4ad	340	15	an	an	DT
cord-019001-ralxw4ad	340	16	integral	integral	JJ
cord-019001-ralxw4ad	340	17	role	role	NN
cord-019001-ralxw4ad	340	18	for	for	IN
cord-019001-ralxw4ad	340	19	endothelial	endothelial	JJ
cord-019001-ralxw4ad	340	20	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	340	21	,	,	,
cord-019001-ralxw4ad	340	22	resulting	result	VBG
cord-019001-ralxw4ad	340	23	in	in	IN
cord-019001-ralxw4ad	340	24	an	an	DT
cord-019001-ralxw4ad	340	25	increase	increase	NN
cord-019001-ralxw4ad	340	26	in	in	IN
cord-019001-ralxw4ad	340	27	factors	factor	NNS
cord-019001-ralxw4ad	340	28	that	that	WDT
cord-019001-ralxw4ad	340	29	favor	favor	VBP
cord-019001-ralxw4ad	340	30	both	both	CC
cord-019001-ralxw4ad	340	31	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	340	32	and	and	CC
cord-019001-ralxw4ad	340	33	mitogenesis	mitogenesis	NN
cord-019001-ralxw4ad	340	34	,	,	,
cord-019001-ralxw4ad	340	35	such	such	JJ
cord-019001-ralxw4ad	340	36	as	as	IN
cord-019001-ralxw4ad	340	37	ET-1	ET-1	NNP
cord-019001-ralxw4ad	340	38	and	and	CC
cord-019001-ralxw4ad	340	39	TXA	TXA	NNP
cord-019001-ralxw4ad	340	40	2	2	CD
cord-019001-ralxw4ad	340	41	,	,	,
cord-019001-ralxw4ad	340	42	and	and	CC
cord-019001-ralxw4ad	340	43	a	a	DT
cord-019001-ralxw4ad	340	44	decrease	decrease	NN
cord-019001-ralxw4ad	340	45	in	in	IN
cord-019001-ralxw4ad	340	46	factors	factor	NNS
cord-019001-ralxw4ad	340	47	that	that	WDT
cord-019001-ralxw4ad	340	48	promote	promote	VBP
cord-019001-ralxw4ad	340	49	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	340	50	and	and	CC
cord-019001-ralxw4ad	340	51	smooth	smooth	JJ
cord-019001-ralxw4ad	340	52	muscle	muscle	NN
cord-019001-ralxw4ad	340	53	antiproliferation	antiproliferation	NN
cord-019001-ralxw4ad	340	54	,	,	,
cord-019001-ralxw4ad	340	55	such	such	JJ
cord-019001-ralxw4ad	340	56	as	as	IN
cord-019001-ralxw4ad	340	57	NO	NO	NNP
cord-019001-ralxw4ad	340	58	and	and	CC
cord-019001-ralxw4ad	340	59	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	340	60	[	[	-LRB-
cord-019001-ralxw4ad	340	61	23	23	CD
cord-019001-ralxw4ad	340	62	,	,	,
cord-019001-ralxw4ad	340	63	101	101	CD
cord-019001-ralxw4ad	340	64	,	,	,
cord-019001-ralxw4ad	340	65	187	187	CD
cord-019001-ralxw4ad	340	66	,	,	,
cord-019001-ralxw4ad	340	67	[	[	-LRB-
cord-019001-ralxw4ad	340	68	232	232	CD
cord-019001-ralxw4ad	340	69	]	]	-RRB-
cord-019001-ralxw4ad	341	1	[	[	-LRB-
cord-019001-ralxw4ad	341	2	233	233	CD
cord-019001-ralxw4ad	341	3	]	]	-RRB-
cord-019001-ralxw4ad	342	1	[	[	-LRB-
cord-019001-ralxw4ad	342	2	234	234	CD
cord-019001-ralxw4ad	342	3	]	]	-RRB-
cord-019001-ralxw4ad	342	4	[	[	-LRB-
cord-019001-ralxw4ad	342	5	235	235	CD
cord-019001-ralxw4ad	342	6	]	]	-RRB-
cord-019001-ralxw4ad	342	7	.	.	.
cord-019001-ralxw4ad	343	1	Other	other	JJ
cord-019001-ralxw4ad	343	2	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	343	3	have	have	VBP
cord-019001-ralxw4ad	343	4	been	be	VBN
cord-019001-ralxw4ad	343	5	investigated	investigate	VBN
cord-019001-ralxw4ad	343	6	including	include	VBG
cord-019001-ralxw4ad	343	7	,	,	,
cord-019001-ralxw4ad	343	8	altered	altered	JJ
cord-019001-ralxw4ad	343	9	gene	gene	NN
cord-019001-ralxw4ad	343	10	expression	expression	NN
cord-019001-ralxw4ad	343	11	,	,	,
cord-019001-ralxw4ad	343	12	coagulation	coagulation	NN
cord-019001-ralxw4ad	343	13	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	343	14	(	(	-LRB-
cord-019001-ralxw4ad	343	15	resulting	result	VBG
cord-019001-ralxw4ad	343	16	in	in	IN
cord-019001-ralxw4ad	343	17	intravascular	intravascular	JJ
cord-019001-ralxw4ad	343	18	thrombosis	thrombosis	NN
cord-019001-ralxw4ad	343	19	)	)	-RRB-
cord-019001-ralxw4ad	343	20	,	,	,
cord-019001-ralxw4ad	343	21	and	and	CC
cord-019001-ralxw4ad	343	22	defects	defect	NNS
cord-019001-ralxw4ad	343	23	of	of	IN
cord-019001-ralxw4ad	343	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	343	25	vascular	vascular	JJ
cord-019001-ralxw4ad	343	26	smooth	smooth	JJ
cord-019001-ralxw4ad	343	27	muscle	muscle	NN
cord-019001-ralxw4ad	343	28	cell	cell	NN
cord-019001-ralxw4ad	343	29	potassium	potassium	NN
cord-019001-ralxw4ad	343	30	channels	channel	NNS
cord-019001-ralxw4ad	343	31	[	[	-LRB-
cord-019001-ralxw4ad	343	32	236	236	CD
cord-019001-ralxw4ad	343	33	]	]	-RRB-
cord-019001-ralxw4ad	343	34	[	[	-LRB-
cord-019001-ralxw4ad	343	35	237	237	CD
cord-019001-ralxw4ad	343	36	]	]	-RRB-
cord-019001-ralxw4ad	343	37	[	[	-LRB-
cord-019001-ralxw4ad	343	38	238	238	CD
cord-019001-ralxw4ad	343	39	]	]	-RRB-
cord-019001-ralxw4ad	343	40	.	.	.
cord-019001-ralxw4ad	344	1	Recent	recent	JJ
cord-019001-ralxw4ad	344	2	advances	advance	NNS
cord-019001-ralxw4ad	344	3	in	in	IN
cord-019001-ralxw4ad	344	4	the	the	DT
cord-019001-ralxw4ad	344	5	understanding	understanding	NN
cord-019001-ralxw4ad	344	6	of	of	IN
cord-019001-ralxw4ad	344	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	344	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	344	9	have	have	VBP
cord-019001-ralxw4ad	344	10	established	establish	VBN
cord-019001-ralxw4ad	344	11	an	an	DT
cord-019001-ralxw4ad	344	12	association	association	NN
cord-019001-ralxw4ad	344	13	with	with	IN
cord-019001-ralxw4ad	344	14	a	a	DT
cord-019001-ralxw4ad	344	15	number	number	NN
cord-019001-ralxw4ad	344	16	of	of	IN
cord-019001-ralxw4ad	344	17	disease	disease	NN
cord-019001-ralxw4ad	344	18	processes	process	NNS
cord-019001-ralxw4ad	344	19	and	and	CC
cord-019001-ralxw4ad	344	20	toxins	toxin	NNS
cord-019001-ralxw4ad	344	21	.	.	.
cord-019001-ralxw4ad	345	1	Thus	thus	RB
cord-019001-ralxw4ad	345	2	,	,	,
cord-019001-ralxw4ad	345	3	it	-PRON-	PRP
cord-019001-ralxw4ad	345	4	is	be	VBZ
cord-019001-ralxw4ad	345	5	now	now	RB
cord-019001-ralxw4ad	345	6	known	know	VBN
cord-019001-ralxw4ad	345	7	that	that	IN
cord-019001-ralxw4ad	345	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	345	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	345	10	can	can	MD
cord-019001-ralxw4ad	345	11	be	be	VB
cord-019001-ralxw4ad	345	12	related	relate	VBN
cord-019001-ralxw4ad	345	13	to	to	IN
cord-019001-ralxw4ad	345	14	collagen	collagen	NN
cord-019001-ralxw4ad	345	15	vascular	vascular	JJ
cord-019001-ralxw4ad	345	16	disease	disease	NN
cord-019001-ralxw4ad	345	17	,	,	,
cord-019001-ralxw4ad	345	18	portal	portal	JJ
cord-019001-ralxw4ad	345	19	hypertension	hypertension	NN
cord-019001-ralxw4ad	345	20	,	,	,
cord-019001-ralxw4ad	345	21	human	human	JJ
cord-019001-ralxw4ad	345	22	immunodefi	immunodefi	NNP
cord-019001-ralxw4ad	345	23	ciency	ciency	NNP
cord-019001-ralxw4ad	345	24	virus	virus	NN
cord-019001-ralxw4ad	345	25	infection	infection	NN
cord-019001-ralxw4ad	345	26	,	,	,
cord-019001-ralxw4ad	345	27	chronic	chronic	JJ
cord-019001-ralxw4ad	345	28	obstructive	obstructive	JJ
cord-019001-ralxw4ad	345	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	345	30	disease	disease	NN
cord-019001-ralxw4ad	345	31	,	,	,
cord-019001-ralxw4ad	345	32	interstitial	interstitial	JJ
cord-019001-ralxw4ad	345	33	lung	lung	NN
cord-019001-ralxw4ad	345	34	disease	disease	NN
cord-019001-ralxw4ad	345	35	,	,	,
cord-019001-ralxw4ad	345	36	sleepdisordered	sleepdisordered	JJ
cord-019001-ralxw4ad	345	37	breathing	breathing	NN
cord-019001-ralxw4ad	345	38	,	,	,
cord-019001-ralxw4ad	345	39	alveolar	alveolar	JJ
cord-019001-ralxw4ad	345	40	hypoventilation	hypoventilation	NN
cord-019001-ralxw4ad	345	41	disorders	disorder	NNS
cord-019001-ralxw4ad	345	42	,	,	,
cord-019001-ralxw4ad	345	43	chronic	chronic	JJ
cord-019001-ralxw4ad	345	44	exposure	exposure	NN
cord-019001-ralxw4ad	345	45	to	to	IN
cord-019001-ralxw4ad	345	46	high	high	JJ
cord-019001-ralxw4ad	345	47	altitudes	altitude	NNS
cord-019001-ralxw4ad	345	48	,	,	,
cord-019001-ralxw4ad	345	49	thromboembolic	thromboembolic	NNP
cord-019001-ralxw4ad	345	50	disease	disease	NN
cord-019001-ralxw4ad	345	51	,	,	,
cord-019001-ralxw4ad	345	52	sickle	sickle	NN
cord-019001-ralxw4ad	345	53	cell	cell	NN
cord-019001-ralxw4ad	345	54	disease	disease	NN
cord-019001-ralxw4ad	345	55	,	,	,
cord-019001-ralxw4ad	345	56	Schistosomiasis	Schistosomiasis	NNP
cord-019001-ralxw4ad	345	57	,	,	,
cord-019001-ralxw4ad	345	58	sarcoidosis	sarcoidosis	NN
cord-019001-ralxw4ad	345	59	,	,	,
cord-019001-ralxw4ad	345	60	thyroid	thyroid	NN
cord-019001-ralxw4ad	345	61	disorders	disorder	NNS
cord-019001-ralxw4ad	345	62	,	,	,
cord-019001-ralxw4ad	345	63	glycogen	glycogen	NN
cord-019001-ralxw4ad	345	64	storage	storage	NN
cord-019001-ralxw4ad	345	65	disease	disease	NN
cord-019001-ralxw4ad	345	66	,	,	,
cord-019001-ralxw4ad	345	67	Gaucher	Gaucher	NNP
cord-019001-ralxw4ad	345	68	disease	disease	NN
cord-019001-ralxw4ad	345	69	,	,	,
cord-019001-ralxw4ad	345	70	hereditary	hereditary	JJ
cord-019001-ralxw4ad	345	71	hemorrhagic	hemorrhagic	JJ
cord-019001-ralxw4ad	345	72	telangiectasia	telangiectasia	NN
cord-019001-ralxw4ad	345	73	,	,	,
cord-019001-ralxw4ad	345	74	myeloproliferative	myeloproliferative	JJ
cord-019001-ralxw4ad	345	75	disorders	disorder	NNS
cord-019001-ralxw4ad	345	76	,	,	,
cord-019001-ralxw4ad	345	77	and	and	CC
cord-019001-ralxw4ad	345	78	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	345	79	capillary	capillary	JJ
cord-019001-ralxw4ad	345	80	hemangiomatosis	hemangiomatosis	NN
cord-019001-ralxw4ad	345	81	.	.	.
cord-019001-ralxw4ad	346	1	In	in	IN
cord-019001-ralxw4ad	346	2	addition	addition	NN
cord-019001-ralxw4ad	346	3	,	,	,
cord-019001-ralxw4ad	346	4	drugs	drug	NNS
cord-019001-ralxw4ad	346	5	or	or	CC
cord-019001-ralxw4ad	346	6	toxins	toxin	NNS
cord-019001-ralxw4ad	346	7	,	,	,
cord-019001-ralxw4ad	346	8	most	most	RBS
cord-019001-ralxw4ad	346	9	notably	notably	RB
cord-019001-ralxw4ad	346	10	anorexigens	anorexigens	NNP
cord-019001-ralxw4ad	346	11	,	,	,
cord-019001-ralxw4ad	346	12	have	have	VBP
cord-019001-ralxw4ad	346	13	been	be	VBN
cord-019001-ralxw4ad	346	14	associated	associate	VBN
cord-019001-ralxw4ad	346	15	with	with	IN
cord-019001-ralxw4ad	346	16	the	the	DT
cord-019001-ralxw4ad	346	17	development	development	NN
cord-019001-ralxw4ad	346	18	of	of	IN
cord-019001-ralxw4ad	346	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	346	20	hypertension	hypertension	NN
cord-019001-ralxw4ad	346	21	[	[	-LRB-
cord-019001-ralxw4ad	346	22	187	187	CD
cord-019001-ralxw4ad	346	23	,	,	,
cord-019001-ralxw4ad	346	24	227	227	CD
cord-019001-ralxw4ad	346	25	]	]	-RRB-
cord-019001-ralxw4ad	346	26	.	.	.
cord-019001-ralxw4ad	347	1	In	in	IN
cord-019001-ralxw4ad	347	2	general	general	JJ
cord-019001-ralxw4ad	347	3	the	the	DT
cord-019001-ralxw4ad	347	4	diagnostic	diagnostic	JJ
cord-019001-ralxw4ad	347	5	work	work	NN
cord-019001-ralxw4ad	347	6	-	-	HYPH
cord-019001-ralxw4ad	347	7	up	up	NN
cord-019001-ralxw4ad	347	8	includes	include	VBZ
cord-019001-ralxw4ad	347	9	history	history	NN
cord-019001-ralxw4ad	347	10	and	and	CC
cord-019001-ralxw4ad	347	11	physical	physical	JJ
cord-019001-ralxw4ad	347	12	examination	examination	NN
cord-019001-ralxw4ad	347	13	,	,	,
cord-019001-ralxw4ad	347	14	electrocardiography	electrocardiography	NN
cord-019001-ralxw4ad	347	15	,	,	,
cord-019001-ralxw4ad	347	16	chest	chest	NN
cord-019001-ralxw4ad	347	17	radiography	radiography	NN
cord-019001-ralxw4ad	347	18	,	,	,
cord-019001-ralxw4ad	347	19	echocardiography	echocardiography	NN
cord-019001-ralxw4ad	347	20	,	,	,
cord-019001-ralxw4ad	347	21	and	and	CC
cord-019001-ralxw4ad	347	22	cardiac	cardiac	JJ
cord-019001-ralxw4ad	347	23	catheterization	catheterization	NN
cord-019001-ralxw4ad	347	24	.	.	.
cord-019001-ralxw4ad	348	1	Serologic	Serologic	NNP
cord-019001-ralxw4ad	348	2	evaluation	evaluation	NN
cord-019001-ralxw4ad	348	3	in	in	IN
cord-019001-ralxw4ad	348	4	order	order	NN
cord-019001-ralxw4ad	348	5	to	to	TO
cord-019001-ralxw4ad	348	6	exclude	exclude	VB
cord-019001-ralxw4ad	348	7	secondary	secondary	JJ
cord-019001-ralxw4ad	348	8	causes	cause	NNS
cord-019001-ralxw4ad	348	9	is	be	VBZ
cord-019001-ralxw4ad	348	10	required	require	VBN
cord-019001-ralxw4ad	348	11	,	,	,
cord-019001-ralxw4ad	348	12	and	and	CC
cord-019001-ralxw4ad	348	13	V	v	NN
cord-019001-ralxw4ad	348	14	/	/	SYM
cord-019001-ralxw4ad	348	15	Q	q	NN
cord-019001-ralxw4ad	348	16	scanning	scanning	NN
cord-019001-ralxw4ad	348	17	to	to	TO
cord-019001-ralxw4ad	348	18	evaluate	evaluate	VB
cord-019001-ralxw4ad	348	19	for	for	IN
cord-019001-ralxw4ad	348	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	348	21	emboli	embolus	NNS
cord-019001-ralxw4ad	348	22	may	may	MD
cord-019001-ralxw4ad	348	23	be	be	VB
cord-019001-ralxw4ad	348	24	necessary	necessary	JJ
cord-019001-ralxw4ad	348	25	.	.	.
cord-019001-ralxw4ad	349	1	Treatment	treatment	NN
cord-019001-ralxw4ad	349	2	strategies	strategy	NNS
cord-019001-ralxw4ad	349	3	for	for	IN
cord-019001-ralxw4ad	349	4	pediatric	pediatric	JJ
cord-019001-ralxw4ad	349	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	349	6	arterial	arterial	JJ
cord-019001-ralxw4ad	349	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	349	8	are	be	VBP
cord-019001-ralxw4ad	349	9	evolving	evolve	VBG
cord-019001-ralxw4ad	349	10	.	.	.
cord-019001-ralxw4ad	350	1	When	when	WRB
cord-019001-ralxw4ad	350	2	the	the	DT
cord-019001-ralxw4ad	350	3	disease	disease	NN
cord-019001-ralxw4ad	350	4	is	be	VBZ
cord-019001-ralxw4ad	350	5	associated	associate	VBN
cord-019001-ralxw4ad	350	6	with	with	IN
cord-019001-ralxw4ad	350	7	a	a	DT
cord-019001-ralxw4ad	350	8	known	know	VBN
cord-019001-ralxw4ad	350	9	disorder	disorder	NN
cord-019001-ralxw4ad	350	10	,	,	,
cord-019001-ralxw4ad	350	11	treatment	treatment	NN
cord-019001-ralxw4ad	350	12	must	must	MD
cord-019001-ralxw4ad	350	13	include	include	VB
cord-019001-ralxw4ad	350	14	specifi	specifi	NNP
cord-019001-ralxw4ad	350	15	c	c	NN
cord-019001-ralxw4ad	350	16	therapy	therapy	NN
cord-019001-ralxw4ad	350	17	aimed	aim	VBN
cord-019001-ralxw4ad	350	18	at	at	IN
cord-019001-ralxw4ad	350	19	the	the	DT
cord-019001-ralxw4ad	350	20	underlying	underlying	JJ
cord-019001-ralxw4ad	350	21	condition	condition	NN
cord-019001-ralxw4ad	350	22	.	.	.
cord-019001-ralxw4ad	351	1	However	however	RB
cord-019001-ralxw4ad	351	2	,	,	,
cord-019001-ralxw4ad	351	3	general	general	JJ
cord-019001-ralxw4ad	351	4	treatments	treatment	NNS
cord-019001-ralxw4ad	351	5	include	include	VBP
cord-019001-ralxw4ad	351	6	the	the	DT
cord-019001-ralxw4ad	351	7	approach	approach	NN
cord-019001-ralxw4ad	351	8	reviewed	review	VBN
cord-019001-ralxw4ad	351	9	above	above	RB
cord-019001-ralxw4ad	351	10	,	,	,
cord-019001-ralxw4ad	351	11	with	with	IN
cord-019001-ralxw4ad	351	12	oxygen	oxygen	NN
cord-019001-ralxw4ad	351	13	,	,	,
cord-019001-ralxw4ad	351	14	calcium	calcium	NN
cord-019001-ralxw4ad	351	15	channel	channel	NN
cord-019001-ralxw4ad	351	16	blockers	blocker	NNS
cord-019001-ralxw4ad	351	17	,	,	,
cord-019001-ralxw4ad	351	18	anticoagulation	anticoagulation	NN
cord-019001-ralxw4ad	351	19	,	,	,
cord-019001-ralxw4ad	351	20	ET	ET	NNP
cord-019001-ralxw4ad	351	21	receptor	receptor	NN
cord-019001-ralxw4ad	351	22	antagonists	antagonist	NNS
cord-019001-ralxw4ad	351	23	,	,	,
cord-019001-ralxw4ad	351	24	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	351	25	analogues	analogue	NNS
cord-019001-ralxw4ad	351	26	,	,	,
cord-019001-ralxw4ad	351	27	acute	acute	JJ
cord-019001-ralxw4ad	351	28	and	and	CC
cord-019001-ralxw4ad	351	29	chronic	chronic	JJ
cord-019001-ralxw4ad	352	1	inhaled	inhale	VBN
cord-019001-ralxw4ad	353	1	NO	no	UH
cord-019001-ralxw4ad	353	2	,	,	,
cord-019001-ralxw4ad	353	3	PDE	pde	NN
cord-019001-ralxw4ad	353	4	type	type	NN
cord-019001-ralxw4ad	354	1	5	5	CD
cord-019001-ralxw4ad	354	2	inhibitors	inhibitor	NNS
cord-019001-ralxw4ad	354	3	,	,	,
cord-019001-ralxw4ad	354	4	atrial	atrial	JJ
cord-019001-ralxw4ad	354	5	septostomy	septostomy	NN
cord-019001-ralxw4ad	354	6	,	,	,
cord-019001-ralxw4ad	354	7	and	and	CC
cord-019001-ralxw4ad	354	8	lung	lung	NN
cord-019001-ralxw4ad	354	9	or	or	CC
cord-019001-ralxw4ad	354	10	heart	heart	NN
cord-019001-ralxw4ad	354	11	-	-	HYPH
cord-019001-ralxw4ad	354	12	lung	lung	NN
cord-019001-ralxw4ad	354	13	transplant	transplant	NN
cord-019001-ralxw4ad	354	14	considerations	consideration	NNS
cord-019001-ralxw4ad	354	15	as	as	IN
cord-019001-ralxw4ad	354	16	indicated	indicate	VBN
cord-019001-ralxw4ad	354	17	[	[	-LRB-
cord-019001-ralxw4ad	354	18	187	187	CD
cord-019001-ralxw4ad	354	19	]	]	-RRB-
cord-019001-ralxw4ad	354	20	.	.	.
cord-019001-ralxw4ad	355	1	Patients	patient	NNS
cord-019001-ralxw4ad	355	2	with	with	IN
cord-019001-ralxw4ad	355	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	355	4	arterial	arterial	JJ
cord-019001-ralxw4ad	355	5	hypertension	hypertension	NN
cord-019001-ralxw4ad	355	6	have	have	VBP
cord-019001-ralxw4ad	355	7	histologic	histologic	JJ
cord-019001-ralxw4ad	355	8	evidence	evidence	NN
cord-019001-ralxw4ad	355	9	of	of	IN
cord-019001-ralxw4ad	355	10	in	in	IN
cord-019001-ralxw4ad	355	11	situ	situ	JJ
cord-019001-ralxw4ad	355	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	355	13	vascular	vascular	JJ
cord-019001-ralxw4ad	355	14	thrombosis	thrombosis	NN
cord-019001-ralxw4ad	355	15	,	,	,
cord-019001-ralxw4ad	355	16	which	which	WDT
cord-019001-ralxw4ad	355	17	is	be	VBZ
cord-019001-ralxw4ad	355	18	the	the	DT
cord-019001-ralxw4ad	355	19	rationale	rationale	NN
cord-019001-ralxw4ad	355	20	for	for	IN
cord-019001-ralxw4ad	355	21	anticoagulation	anticoagulation	NN
cord-019001-ralxw4ad	355	22	therapy	therapy	NN
cord-019001-ralxw4ad	355	23	.	.	.
cord-019001-ralxw4ad	356	1	Although	although	IN
cord-019001-ralxw4ad	356	2	several	several	JJ
cord-019001-ralxw4ad	356	3	adult	adult	NN
cord-019001-ralxw4ad	356	4	studies	study	NNS
cord-019001-ralxw4ad	356	5	have	have	VBP
cord-019001-ralxw4ad	356	6	demonstrated	demonstrate	VBN
cord-019001-ralxw4ad	356	7	its	-PRON-	PRP$
cord-019001-ralxw4ad	356	8	effi	effi	NNP
cord-019001-ralxw4ad	356	9	cacy	cacy	NNP
cord-019001-ralxw4ad	356	10	,	,	,
cord-019001-ralxw4ad	356	11	pediatric	pediatric	JJ
cord-019001-ralxw4ad	356	12	studies	study	NNS
cord-019001-ralxw4ad	356	13	are	be	VBP
cord-019001-ralxw4ad	356	14	lacking	lack	VBG
cord-019001-ralxw4ad	356	15	[	[	-LRB-
cord-019001-ralxw4ad	356	16	239	239	CD
cord-019001-ralxw4ad	356	17	,	,	,
cord-019001-ralxw4ad	356	18	240	240	CD
cord-019001-ralxw4ad	356	19	]	]	-RRB-
cord-019001-ralxw4ad	356	20	.	.	.
cord-019001-ralxw4ad	357	1	Currently	currently	RB
cord-019001-ralxw4ad	357	2	,	,	,
cord-019001-ralxw4ad	357	3	warfarin	warfarin	NNP
cord-019001-ralxw4ad	357	4	is	be	VBZ
cord-019001-ralxw4ad	357	5	the	the	DT
cord-019001-ralxw4ad	357	6	treatment	treatment	NN
cord-019001-ralxw4ad	357	7	of	of	IN
cord-019001-ralxw4ad	357	8	choice	choice	NN
cord-019001-ralxw4ad	357	9	for	for	IN
cord-019001-ralxw4ad	357	10	adult	adult	NN
cord-019001-ralxw4ad	357	11	patients	patient	NNS
cord-019001-ralxw4ad	357	12	and	and	CC
cord-019001-ralxw4ad	357	13	in	in	IN
cord-019001-ralxw4ad	357	14	large	large	JJ
cord-019001-ralxw4ad	357	15	pediatric	pediatric	JJ
cord-019001-ralxw4ad	357	16	centers	center	NNS
cord-019001-ralxw4ad	357	17	with	with	IN
cord-019001-ralxw4ad	357	18	signifi	signifi	NNP
cord-019001-ralxw4ad	357	19	ca	can	MD
cord-019001-ralxw4ad	357	20	nt	not	RB
cord-019001-ralxw4ad	357	21	experience	experience	VB
cord-019001-ralxw4ad	357	22	with	with	IN
cord-019001-ralxw4ad	357	23	pediatric	pediatric	JJ
cord-019001-ralxw4ad	357	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	357	25	arterial	arterial	JJ
cord-019001-ralxw4ad	357	26	hypertension	hypertension	NN
cord-019001-ralxw4ad	357	27	.	.	.
cord-019001-ralxw4ad	358	1	Low	low	JJ
cord-019001-ralxw4ad	358	2	-	-	HYPH
cord-019001-ralxw4ad	358	3	molecularweight	molecularweight	NN
cord-019001-ralxw4ad	358	4	heparin	heparin	NN
cord-019001-ralxw4ad	358	5	is	be	VBZ
cord-019001-ralxw4ad	358	6	another	another	DT
cord-019001-ralxw4ad	358	7	alternative	alternative	JJ
cord-019001-ralxw4ad	358	8	[	[	-LRB-
cord-019001-ralxw4ad	358	9	241	241	CD
cord-019001-ralxw4ad	358	10	]	]	-RRB-
cord-019001-ralxw4ad	358	11	;	;	:
cord-019001-ralxw4ad	358	12	aspirin	aspirin	NN
cord-019001-ralxw4ad	358	13	does	do	VBZ
cord-019001-ralxw4ad	358	14	not	not	RB
cord-019001-ralxw4ad	358	15	have	have	VB
cord-019001-ralxw4ad	358	16	any	any	DT
cord-019001-ralxw4ad	358	17	demonstrated	demonstrate	VBN
cord-019001-ralxw4ad	358	18	effi	effi	NNP
cord-019001-ralxw4ad	358	19	cacy	cacy	NNP
cord-019001-ralxw4ad	358	20	.	.	.
cord-019001-ralxw4ad	359	1	Chronic	chronic	JJ
cord-019001-ralxw4ad	359	2	calcium	calcium	NN
cord-019001-ralxw4ad	359	3	channel	channel	NN
cord-019001-ralxw4ad	359	4	blockade	blockade	NN
cord-019001-ralxw4ad	359	5	is	be	VBZ
cord-019001-ralxw4ad	359	6	effi	effi	NNP
cord-019001-ralxw4ad	359	7	cacious	cacious	NNP
cord-019001-ralxw4ad	359	8	for	for	IN
cord-019001-ralxw4ad	359	9	a	a	DT
cord-019001-ralxw4ad	359	10	subset	subset	NN
cord-019001-ralxw4ad	359	11	of	of	IN
cord-019001-ralxw4ad	359	12	adults	adult	NNS
cord-019001-ralxw4ad	359	13	and	and	CC
cord-019001-ralxw4ad	359	14	children	child	NNS
cord-019001-ralxw4ad	359	15	with	with	IN
cord-019001-ralxw4ad	359	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	359	17	arterial	arterial	JJ
cord-019001-ralxw4ad	359	18	hypertension	hypertension	NN
cord-019001-ralxw4ad	359	19	.	.	.
cord-019001-ralxw4ad	360	1	In	in	IN
cord-019001-ralxw4ad	360	2	fact	fact	NN
cord-019001-ralxw4ad	360	3	,	,	,
cord-019001-ralxw4ad	360	4	whereas	whereas	IN
cord-019001-ralxw4ad	360	5	less	less	JJR
cord-019001-ralxw4ad	360	6	than	than	IN
cord-019001-ralxw4ad	360	7	25	25	CD
cord-019001-ralxw4ad	360	8	%	%	NN
cord-019001-ralxw4ad	360	9	of	of	IN
cord-019001-ralxw4ad	360	10	adults	adult	NNS
cord-019001-ralxw4ad	360	11	respond	respond	VBP
cord-019001-ralxw4ad	360	12	to	to	IN
cord-019001-ralxw4ad	360	13	calcium	calcium	NN
cord-019001-ralxw4ad	360	14	channel	channel	NN
cord-019001-ralxw4ad	360	15	blockers	blocker	NNS
cord-019001-ralxw4ad	360	16	,	,	,
cord-019001-ralxw4ad	360	17	up	up	IN
cord-019001-ralxw4ad	360	18	to	to	TO
cord-019001-ralxw4ad	360	19	40	40	CD
cord-019001-ralxw4ad	360	20	%	%	NN
cord-019001-ralxw4ad	360	21	of	of	IN
cord-019001-ralxw4ad	360	22	children	child	NNS
cord-019001-ralxw4ad	360	23	are	be	VBP
cord-019001-ralxw4ad	360	24	positive	positive	JJ
cord-019001-ralxw4ad	360	25	responders	responder	NNS
cord-019001-ralxw4ad	360	26	[	[	-LRB-
cord-019001-ralxw4ad	360	27	186	186	CD
cord-019001-ralxw4ad	360	28	,	,	,
cord-019001-ralxw4ad	360	29	242	242	CD
cord-019001-ralxw4ad	360	30	]	]	-RRB-
cord-019001-ralxw4ad	360	31	.	.	.
cord-019001-ralxw4ad	361	1	It	-PRON-	PRP
cord-019001-ralxw4ad	361	2	is	be	VBZ
cord-019001-ralxw4ad	361	3	worth	worth	JJ
cord-019001-ralxw4ad	361	4	noting	note	VBG
cord-019001-ralxw4ad	361	5	that	that	IN
cord-019001-ralxw4ad	361	6	calcium	calcium	NN
cord-019001-ralxw4ad	361	7	channel	channel	NN
cord-019001-ralxw4ad	361	8	blockers	blocker	NNS
cord-019001-ralxw4ad	361	9	are	be	VBP
cord-019001-ralxw4ad	361	10	not	not	RB
cord-019001-ralxw4ad	361	11	utilized	utilize	VBN
cord-019001-ralxw4ad	361	12	in	in	IN
cord-019001-ralxw4ad	361	13	the	the	DT
cord-019001-ralxw4ad	361	14	management	management	NN
cord-019001-ralxw4ad	361	15	of	of	IN
cord-019001-ralxw4ad	361	16	other	other	JJ
cord-019001-ralxw4ad	361	17	common	common	JJ
cord-019001-ralxw4ad	361	18	causes	cause	NNS
cord-019001-ralxw4ad	361	19	of	of	IN
cord-019001-ralxw4ad	361	20	pediatric	pediatric	JJ
cord-019001-ralxw4ad	361	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	361	22	hypertension	hypertension	NN
cord-019001-ralxw4ad	361	23	,	,	,
cord-019001-ralxw4ad	361	24	such	such	JJ
cord-019001-ralxw4ad	361	25	as	as	IN
cord-019001-ralxw4ad	361	26	PPHN	PPHN	NNS
cord-019001-ralxw4ad	361	27	and	and	CC
cord-019001-ralxw4ad	361	28	congenital	congenital	JJ
cord-019001-ralxw4ad	361	29	heart	heart	NN
cord-019001-ralxw4ad	361	30	disease	disease	NN
cord-019001-ralxw4ad	361	31	.	.	.
cord-019001-ralxw4ad	362	1	Indeed	indeed	RB
cord-019001-ralxw4ad	362	2	,	,	,
cord-019001-ralxw4ad	362	3	calcium	calcium	NN
cord-019001-ralxw4ad	362	4	channel	channel	NN
cord-019001-ralxw4ad	362	5	blockade	blockade	NN
cord-019001-ralxw4ad	362	6	should	should	MD
cord-019001-ralxw4ad	362	7	be	be	VB
cord-019001-ralxw4ad	362	8	avoided	avoid	VBN
cord-019001-ralxw4ad	362	9	in	in	IN
cord-019001-ralxw4ad	362	10	neonates	neonate	NNS
cord-019001-ralxw4ad	362	11	and	and	CC
cord-019001-ralxw4ad	362	12	after	after	IN
cord-019001-ralxw4ad	362	13	congenital	congenital	JJ
cord-019001-ralxw4ad	362	14	heart	heart	NN
cord-019001-ralxw4ad	362	15	surgery	surgery	NN
cord-019001-ralxw4ad	362	16	.	.	.
cord-019001-ralxw4ad	363	1	However	however	RB
cord-019001-ralxw4ad	363	2	,	,	,
cord-019001-ralxw4ad	363	3	studies	study	NNS
cord-019001-ralxw4ad	363	4	indicate	indicate	VBP
cord-019001-ralxw4ad	363	5	that	that	IN
cord-019001-ralxw4ad	363	6	long	long	RB
cord-019001-ralxw4ad	363	7	-	-	HYPH
cord-019001-ralxw4ad	363	8	acting	act	VBG
cord-019001-ralxw4ad	363	9	calcium	calcium	NN
cord-019001-ralxw4ad	363	10	channel	channel	NN
cord-019001-ralxw4ad	363	11	blockers	blocker	NNS
cord-019001-ralxw4ad	363	12	,	,	,
cord-019001-ralxw4ad	363	13	such	such	JJ
cord-019001-ralxw4ad	363	14	as	as	IN
cord-019001-ralxw4ad	363	15	nifedipine	nifedipine	NN
cord-019001-ralxw4ad	363	16	and	and	CC
cord-019001-ralxw4ad	363	17	amlodipine	amlodipine	NN
cord-019001-ralxw4ad	363	18	,	,	,
cord-019001-ralxw4ad	363	19	are	be	VBP
cord-019001-ralxw4ad	363	20	well	well	RB
cord-019001-ralxw4ad	363	21	tolerated	tolerate	VBN
cord-019001-ralxw4ad	363	22	in	in	IN
cord-019001-ralxw4ad	363	23	children	child	NNS
cord-019001-ralxw4ad	363	24	with	with	IN
cord-019001-ralxw4ad	363	25	primary	primary	JJ
cord-019001-ralxw4ad	363	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	363	27	hypertension	hypertension	NN
cord-019001-ralxw4ad	363	28	.	.	.
cord-019001-ralxw4ad	364	1	An	an	DT
cord-019001-ralxw4ad	364	2	important	important	JJ
cord-019001-ralxw4ad	364	3	caveat	caveat	NN
cord-019001-ralxw4ad	364	4	is	be	VBZ
cord-019001-ralxw4ad	364	5	that	that	IN
cord-019001-ralxw4ad	364	6	a	a	DT
cord-019001-ralxw4ad	364	7	positive	positive	JJ
cord-019001-ralxw4ad	364	8	response	response	NN
cord-019001-ralxw4ad	364	9	to	to	IN
cord-019001-ralxw4ad	364	10	calcium	calcium	NN
cord-019001-ralxw4ad	364	11	channel	channel	NN
cord-019001-ralxw4ad	364	12	blockers	blocker	NNS
cord-019001-ralxw4ad	364	13	(	(	-LRB-
cord-019001-ralxw4ad	364	14	i.e.	i.e.	FW
cord-019001-ralxw4ad	364	15	,	,	,
cord-019001-ralxw4ad	364	16	an	an	DT
cord-019001-ralxw4ad	364	17	acute	acute	JJ
cord-019001-ralxw4ad	364	18	reduction	reduction	NN
cord-019001-ralxw4ad	364	19	in	in	IN
cord-019001-ralxw4ad	364	20	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	364	21	arterial	arterial	JJ
cord-019001-ralxw4ad	364	22	pressure	pressure	NN
cord-019001-ralxw4ad	364	23	)	)	-RRB-
cord-019001-ralxw4ad	364	24	must	must	MD
cord-019001-ralxw4ad	364	25	be	be	VB
cord-019001-ralxw4ad	364	26	demonstrated	demonstrate	VBN
cord-019001-ralxw4ad	364	27	as	as	IN
cord-019001-ralxw4ad	364	28	a	a	DT
cord-019001-ralxw4ad	364	29	part	part	NN
cord-019001-ralxw4ad	364	30	of	of	IN
cord-019001-ralxw4ad	364	31	acute	acute	JJ
cord-019001-ralxw4ad	364	32	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	364	33	reactivity	reactivity	NN
cord-019001-ralxw4ad	364	34	testing	testing	NN
cord-019001-ralxw4ad	364	35	.	.	.
cord-019001-ralxw4ad	365	1	Children	child	NNS
cord-019001-ralxw4ad	365	2	without	without	IN
cord-019001-ralxw4ad	365	3	a	a	DT
cord-019001-ralxw4ad	365	4	positive	positive	JJ
cord-019001-ralxw4ad	365	5	acute	acute	JJ
cord-019001-ralxw4ad	365	6	response	response	NN
cord-019001-ralxw4ad	365	7	do	do	VBP
cord-019001-ralxw4ad	365	8	not	not	RB
cord-019001-ralxw4ad	365	9	benefi	benefi	VB
cord-019001-ralxw4ad	365	10	t	t	NN
cord-019001-ralxw4ad	365	11	from	from	IN
cord-019001-ralxw4ad	365	12	chronic	chronic	JJ
cord-019001-ralxw4ad	365	13	treatment	treatment	NN
cord-019001-ralxw4ad	365	14	.	.	.
cord-019001-ralxw4ad	366	1	Prostaglandins	prostaglandin	NNS
cord-019001-ralxw4ad	366	2	are	be	VBP
cord-019001-ralxw4ad	366	3	a	a	DT
cord-019001-ralxw4ad	366	4	mainstay	mainstay	NN
cord-019001-ralxw4ad	366	5	of	of	IN
cord-019001-ralxw4ad	366	6	therapy	therapy	NN
cord-019001-ralxw4ad	366	7	for	for	IN
cord-019001-ralxw4ad	366	8	patients	patient	NNS
cord-019001-ralxw4ad	366	9	with	with	IN
cord-019001-ralxw4ad	366	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	366	11	arterial	arterial	JJ
cord-019001-ralxw4ad	366	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	366	13	.	.	.
cord-019001-ralxw4ad	367	1	In	in	IN
cord-019001-ralxw4ad	367	2	general	general	JJ
cord-019001-ralxw4ad	367	3	,	,	,
cord-019001-ralxw4ad	367	4	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	367	5	(	(	-LRB-
cord-019001-ralxw4ad	367	6	epoprostenol	epoprostenol	NNP
cord-019001-ralxw4ad	367	7	)	)	-RRB-
cord-019001-ralxw4ad	367	8	is	be	VBZ
cord-019001-ralxw4ad	367	9	administered	administer	VBN
cord-019001-ralxw4ad	367	10	as	as	IN
cord-019001-ralxw4ad	367	11	a	a	DT
cord-019001-ralxw4ad	367	12	continuous	continuous	JJ
cord-019001-ralxw4ad	367	13	infusion	infusion	NN
cord-019001-ralxw4ad	367	14	,	,	,
cord-019001-ralxw4ad	367	15	necessitating	necessitate	VBG
cord-019001-ralxw4ad	367	16	a	a	DT
cord-019001-ralxw4ad	367	17	permanent	permanent	JJ
cord-019001-ralxw4ad	367	18	indwelling	indwell	VBG
cord-019001-ralxw4ad	367	19	central	central	JJ
cord-019001-ralxw4ad	367	20	catheter	catheter	NN
cord-019001-ralxw4ad	367	21	,	,	,
cord-019001-ralxw4ad	367	22	with	with	IN
cord-019001-ralxw4ad	367	23	its	-PRON-	PRP$
cord-019001-ralxw4ad	367	24	associated	associate	VBN
cord-019001-ralxw4ad	367	25	risks	risk	NNS
cord-019001-ralxw4ad	367	26	[	[	-LRB-
cord-019001-ralxw4ad	367	27	181	181	CD
cord-019001-ralxw4ad	367	28	]	]	-RRB-
cord-019001-ralxw4ad	367	29	[	[	-LRB-
cord-019001-ralxw4ad	367	30	182	182	CD
cord-019001-ralxw4ad	367	31	]	]	-RRB-
cord-019001-ralxw4ad	367	32	[	[	-LRB-
cord-019001-ralxw4ad	367	33	183	183	CD
cord-019001-ralxw4ad	367	34	]	]	-RRB-
cord-019001-ralxw4ad	367	35	[	[	-LRB-
cord-019001-ralxw4ad	367	36	184	184	CD
cord-019001-ralxw4ad	367	37	]	]	-RRB-
cord-019001-ralxw4ad	367	38	[	[	-LRB-
cord-019001-ralxw4ad	367	39	185	185	CD
cord-019001-ralxw4ad	367	40	]	]	-RRB-
cord-019001-ralxw4ad	367	41	.	.	.
cord-019001-ralxw4ad	368	1	However	however	RB
cord-019001-ralxw4ad	368	2	,	,	,
cord-019001-ralxw4ad	368	3	various	various	JJ
cord-019001-ralxw4ad	368	4	other	other	JJ
cord-019001-ralxw4ad	368	5	formulations	formulation	NNS
cord-019001-ralxw4ad	368	6	including	include	VBG
cord-019001-ralxw4ad	368	7	oral	oral	JJ
cord-019001-ralxw4ad	368	8	,	,	,
cord-019001-ralxw4ad	368	9	inhaled	inhale	VBN
cord-019001-ralxw4ad	368	10	,	,	,
cord-019001-ralxw4ad	368	11	and	and	CC
cord-019001-ralxw4ad	368	12	subcutaneous	subcutaneous	JJ
cord-019001-ralxw4ad	368	13	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	368	14	analogues	analogue	NNS
cord-019001-ralxw4ad	368	15	have	have	VBP
cord-019001-ralxw4ad	368	16	been	be	VBN
cord-019001-ralxw4ad	368	17	developed	develop	VBN
cord-019001-ralxw4ad	368	18	and	and	CC
cord-019001-ralxw4ad	368	19	are	be	VBP
cord-019001-ralxw4ad	368	20	in	in	IN
cord-019001-ralxw4ad	368	21	various	various	JJ
cord-019001-ralxw4ad	368	22	stages	stage	NNS
cord-019001-ralxw4ad	368	23	of	of	IN
cord-019001-ralxw4ad	368	24	clinical	clinical	JJ
cord-019001-ralxw4ad	368	25	investigation	investigation	NN
cord-019001-ralxw4ad	368	26	[	[	-LRB-
cord-019001-ralxw4ad	368	27	243	243	CD
cord-019001-ralxw4ad	368	28	]	]	-RRB-
cord-019001-ralxw4ad	368	29	[	[	-LRB-
cord-019001-ralxw4ad	368	30	244	244	CD
cord-019001-ralxw4ad	368	31	]	]	-RRB-
cord-019001-ralxw4ad	369	1	[	[	-LRB-
cord-019001-ralxw4ad	369	2	245	245	CD
cord-019001-ralxw4ad	369	3	]	]	-RRB-
cord-019001-ralxw4ad	369	4	[	[	-LRB-
cord-019001-ralxw4ad	369	5	246	246	CD
cord-019001-ralxw4ad	369	6	]	]	-RRB-
cord-019001-ralxw4ad	369	7	.	.	.
cord-019001-ralxw4ad	370	1	Supplemental	supplemental	JJ
cord-019001-ralxw4ad	370	2	oxygen	oxygen	NN
cord-019001-ralxw4ad	370	3	,	,	,
cord-019001-ralxw4ad	370	4	cardiac	cardiac	JJ
cord-019001-ralxw4ad	370	5	glycosides	glycoside	NNS
cord-019001-ralxw4ad	370	6	,	,	,
cord-019001-ralxw4ad	370	7	antiarrhythmic	antiarrhythmic	JJ
cord-019001-ralxw4ad	370	8	therapy	therapy	NN
cord-019001-ralxw4ad	370	9	,	,	,
cord-019001-ralxw4ad	370	10	and	and	CC
cord-019001-ralxw4ad	370	11	inotropic	inotropic	NNP
cord-019001-ralxw4ad	370	12	agents	agent	NNS
cord-019001-ralxw4ad	370	13	are	be	VBP
cord-019001-ralxw4ad	370	14	also	also	RB
cord-019001-ralxw4ad	370	15	variably	variably	RB
cord-019001-ralxw4ad	370	16	utilized	utilize	VBN
cord-019001-ralxw4ad	370	17	in	in	IN
cord-019001-ralxw4ad	370	18	certain	certain	JJ
cord-019001-ralxw4ad	370	19	patients	patient	NNS
cord-019001-ralxw4ad	370	20	[	[	-LRB-
cord-019001-ralxw4ad	370	21	187	187	CD
cord-019001-ralxw4ad	370	22	,	,	,
cord-019001-ralxw4ad	370	23	247	247	CD
cord-019001-ralxw4ad	370	24	]	]	-RRB-
cord-019001-ralxw4ad	370	25	.	.	.
cord-019001-ralxw4ad	371	1	Diuretic	diuretic	JJ
cord-019001-ralxw4ad	371	2	therapy	therapy	NN
cord-019001-ralxw4ad	371	3	is	be	VBZ
cord-019001-ralxw4ad	371	4	also	also	RB
cord-019001-ralxw4ad	371	5	often	often	RB
cord-019001-ralxw4ad	371	6	benefi	benefi	JJ
cord-019001-ralxw4ad	371	7	cial	cial	NN
cord-019001-ralxw4ad	371	8	,	,	,
cord-019001-ralxw4ad	371	9	keeping	keep	VBG
cord-019001-ralxw4ad	371	10	in	in	IN
cord-019001-ralxw4ad	371	11	mind	mind	NN
cord-019001-ralxw4ad	371	12	that	that	IN
cord-019001-ralxw4ad	371	13	these	these	DT
cord-019001-ralxw4ad	371	14	patients	patient	NNS
cord-019001-ralxw4ad	371	15	may	may	MD
cord-019001-ralxw4ad	371	16	require	require	VB
cord-019001-ralxw4ad	371	17	elevated	elevated	JJ
cord-019001-ralxw4ad	371	18	right	right	JJ
cord-019001-ralxw4ad	371	19	ventricular	ventricular	JJ
cord-019001-ralxw4ad	371	20	preload	preload	NN
cord-019001-ralxw4ad	371	21	.	.	.
cord-019001-ralxw4ad	372	1	Based	base	VBN
cord-019001-ralxw4ad	372	2	on	on	IN
cord-019001-ralxw4ad	372	3	an	an	DT
cord-019001-ralxw4ad	372	4	expanding	expand	VBG
cord-019001-ralxw4ad	372	5	understanding	understanding	NN
cord-019001-ralxw4ad	372	6	of	of	IN
cord-019001-ralxw4ad	372	7	the	the	DT
cord-019001-ralxw4ad	372	8	disease	disease	NN
cord-019001-ralxw4ad	372	9	process	process	NN
cord-019001-ralxw4ad	372	10	,	,	,
cord-019001-ralxw4ad	372	11	future	future	JJ
cord-019001-ralxw4ad	372	12	therapies	therapy	NNS
cord-019001-ralxw4ad	372	13	might	may	MD
cord-019001-ralxw4ad	372	14	include	include	VB
cord-019001-ralxw4ad	372	15	elastase	elastase	NN
cord-019001-ralxw4ad	372	16	inhibitors	inhibitor	NNS
cord-019001-ralxw4ad	372	17	and	and	CC
cord-019001-ralxw4ad	372	18	gene	gene	NN
cord-019001-ralxw4ad	372	19	therapy	therapy	NN
cord-019001-ralxw4ad	372	20	[	[	-LRB-
cord-019001-ralxw4ad	372	21	248	248	CD
cord-019001-ralxw4ad	372	22	,	,	,
cord-019001-ralxw4ad	372	23	249	249	CD
cord-019001-ralxw4ad	372	24	]	]	-RRB-
cord-019001-ralxw4ad	372	25	.	.	.
cord-019001-ralxw4ad	373	1	As	as	IN
cord-019001-ralxw4ad	373	2	noted	note	VBN
cord-019001-ralxw4ad	373	3	previously	previously	RB
cord-019001-ralxw4ad	373	4	,	,	,
cord-019001-ralxw4ad	373	5	atrial	atrial	JJ
cord-019001-ralxw4ad	373	6	septostomy	septostomy	NN
cord-019001-ralxw4ad	373	7	may	may	MD
cord-019001-ralxw4ad	373	8	have	have	VB
cord-019001-ralxw4ad	373	9	a	a	DT
cord-019001-ralxw4ad	373	10	role	role	NN
cord-019001-ralxw4ad	373	11	in	in	IN
cord-019001-ralxw4ad	373	12	the	the	DT
cord-019001-ralxw4ad	373	13	management	management	NN
cord-019001-ralxw4ad	373	14	of	of	IN
cord-019001-ralxw4ad	373	15	a	a	DT
cord-019001-ralxw4ad	373	16	select	select	JJ
cord-019001-ralxw4ad	373	17	group	group	NN
cord-019001-ralxw4ad	373	18	of	of	IN
cord-019001-ralxw4ad	373	19	patients	patient	NNS
cord-019001-ralxw4ad	373	20	[	[	-LRB-
cord-019001-ralxw4ad	373	21	250	250	CD
cord-019001-ralxw4ad	373	22	]	]	-RRB-
cord-019001-ralxw4ad	373	23	.	.	.
cord-019001-ralxw4ad	374	1	However	however	RB
cord-019001-ralxw4ad	374	2	,	,	,
cord-019001-ralxw4ad	374	3	atrial	atrial	JJ
cord-019001-ralxw4ad	374	4	septostomy	septostomy	NN
cord-019001-ralxw4ad	374	5	in	in	IN
cord-019001-ralxw4ad	374	6	the	the	DT
cord-019001-ralxw4ad	374	7	setting	setting	NN
cord-019001-ralxw4ad	374	8	of	of	IN
cord-019001-ralxw4ad	374	9	an	an	DT
cord-019001-ralxw4ad	374	10	acute	acute	JJ
cord-019001-ralxw4ad	374	11	exacerbation	exacerbation	NN
cord-019001-ralxw4ad	374	12	of	of	IN
cord-019001-ralxw4ad	374	13	chronic	chronic	JJ
cord-019001-ralxw4ad	374	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	374	15	hypertension	hypertension	NN
cord-019001-ralxw4ad	374	16	may	may	MD
cord-019001-ralxw4ad	374	17	lead	lead	VB
cord-019001-ralxw4ad	374	18	to	to	IN
cord-019001-ralxw4ad	374	19	unacceptable	unacceptable	JJ
cord-019001-ralxw4ad	374	20	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	374	21	because	because	IN
cord-019001-ralxw4ad	374	22	of	of	IN
cord-019001-ralxw4ad	374	23	excess	excess	JJ
cord-019001-ralxw4ad	374	24	right	right	NN
cord-019001-ralxw4ad	374	25	-	-	HYPH
cord-019001-ralxw4ad	374	26	to	to	IN
cord-019001-ralxw4ad	374	27	-	-	HYPH
cord-019001-ralxw4ad	374	28	left	leave	VBN
cord-019001-ralxw4ad	374	29	atrial	atrial	JJ
cord-019001-ralxw4ad	374	30	shunting	shunting	NN
cord-019001-ralxw4ad	374	31	.	.	.
cord-019001-ralxw4ad	375	1	Finally	finally	RB
cord-019001-ralxw4ad	375	2	,	,	,
cord-019001-ralxw4ad	375	3	heart	heart	NN
cord-019001-ralxw4ad	375	4	-	-	HYPH
cord-019001-ralxw4ad	375	5	lung	lung	NN
cord-019001-ralxw4ad	375	6	,	,	,
cord-019001-ralxw4ad	375	7	single	single	JJ
cord-019001-ralxw4ad	375	8	-	-	HYPH
cord-019001-ralxw4ad	375	9	lung	lung	NN
cord-019001-ralxw4ad	375	10	,	,	,
cord-019001-ralxw4ad	375	11	or	or	CC
cord-019001-ralxw4ad	375	12	bilateral	bilateral	JJ
cord-019001-ralxw4ad	375	13	lung	lung	NN
cord-019001-ralxw4ad	375	14	transplantation	transplantation	NN
cord-019001-ralxw4ad	375	15	has	have	VBZ
cord-019001-ralxw4ad	375	16	been	be	VBN
cord-019001-ralxw4ad	375	17	successful	successful	JJ
cord-019001-ralxw4ad	375	18	in	in	IN
cord-019001-ralxw4ad	375	19	pediatric	pediatric	JJ
cord-019001-ralxw4ad	375	20	patients	patient	NNS
cord-019001-ralxw4ad	375	21	with	with	IN
cord-019001-ralxw4ad	375	22	terminal	terminal	JJ
cord-019001-ralxw4ad	375	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	375	24	hypertension	hypertension	NN
cord-019001-ralxw4ad	375	25	[	[	-LRB-
cord-019001-ralxw4ad	375	26	251	251	CD
cord-019001-ralxw4ad	375	27	,	,	,
cord-019001-ralxw4ad	375	28	252	252	CD
cord-019001-ralxw4ad	375	29	]	]	-RRB-
cord-019001-ralxw4ad	375	30	.	.	.
cord-019001-ralxw4ad	376	1	The	the	DT
cord-019001-ralxw4ad	376	2	International	International	NNP
cord-019001-ralxw4ad	376	3	Society	Society	NNP
cord-019001-ralxw4ad	376	4	for	for	IN
cord-019001-ralxw4ad	376	5	Heart	Heart	NNP
cord-019001-ralxw4ad	376	6	and	and	CC
cord-019001-ralxw4ad	376	7	Lung	Lung	NNP
cord-019001-ralxw4ad	376	8	Transplantation	Transplantation	NNP
cord-019001-ralxw4ad	376	9	reports	report	VBZ
cord-019001-ralxw4ad	376	10	survival	survival	NN
cord-019001-ralxw4ad	376	11	of	of	IN
cord-019001-ralxw4ad	376	12	approximately	approximately	RB
cord-019001-ralxw4ad	376	13	50	50	CD
cord-019001-ralxw4ad	376	14	%	%	NN
cord-019001-ralxw4ad	376	15	at	at	IN
cord-019001-ralxw4ad	376	16	5	5	CD
cord-019001-ralxw4ad	376	17	years	year	NNS
cord-019001-ralxw4ad	376	18	in	in	IN
cord-019001-ralxw4ad	376	19	pediatric	pediatric	JJ
cord-019001-ralxw4ad	376	20	patients	patient	NNS
cord-019001-ralxw4ad	376	21	[	[	-LRB-
cord-019001-ralxw4ad	376	22	253	253	CD
cord-019001-ralxw4ad	376	23	]	]	-RRB-
cord-019001-ralxw4ad	376	24	.	.	.
cord-019001-ralxw4ad	377	1	Consensus	consensus	NN
cord-019001-ralxw4ad	377	2	is	be	VBZ
cord-019001-ralxw4ad	377	3	lacking	lack	VBG
cord-019001-ralxw4ad	377	4	as	as	IN
cord-019001-ralxw4ad	377	5	to	to	IN
cord-019001-ralxw4ad	377	6	the	the	DT
cord-019001-ralxw4ad	377	7	best	good	JJS
cord-019001-ralxw4ad	377	8	type	type	NN
cord-019001-ralxw4ad	377	9	of	of	IN
cord-019001-ralxw4ad	377	10	transplant	transplant	NN
cord-019001-ralxw4ad	377	11	.	.	.
cord-019001-ralxw4ad	378	1	Increases	increase	NNS
cord-019001-ralxw4ad	378	2	in	in	IN
cord-019001-ralxw4ad	378	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	378	4	arterial	arterial	JJ
cord-019001-ralxw4ad	378	5	pressure	pressure	NN
cord-019001-ralxw4ad	378	6	in	in	IN
cord-019001-ralxw4ad	378	7	response	response	NN
cord-019001-ralxw4ad	378	8	to	to	IN
cord-019001-ralxw4ad	378	9	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	378	10	are	be	VBP
cord-019001-ralxw4ad	378	11	well	well	RB
cord-019001-ralxw4ad	378	12	described	describe	VBN
cord-019001-ralxw4ad	378	13	.	.	.
cord-019001-ralxw4ad	379	1	Clinical	clinical	JJ
cord-019001-ralxw4ad	379	2	and	and	CC
cord-019001-ralxw4ad	379	3	experimental	experimental	JJ
cord-019001-ralxw4ad	379	4	evidence	evidence	NN
cord-019001-ralxw4ad	379	5	suggests	suggest	VBZ
cord-019001-ralxw4ad	379	6	that	that	IN
cord-019001-ralxw4ad	379	7	prolonged	prolong	VBN
cord-019001-ralxw4ad	379	8	exposure	exposure	NN
cord-019001-ralxw4ad	379	9	or	or	CC
cord-019001-ralxw4ad	379	10	chronic	chronic	JJ
cord-019001-ralxw4ad	379	11	intermittent	intermittent	JJ
cord-019001-ralxw4ad	379	12	exposure	exposure	NN
cord-019001-ralxw4ad	379	13	to	to	IN
cord-019001-ralxw4ad	379	14	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	379	15	can	can	MD
cord-019001-ralxw4ad	379	16	result	result	VB
cord-019001-ralxw4ad	379	17	in	in	IN
cord-019001-ralxw4ad	379	18	functional	functional	JJ
cord-019001-ralxw4ad	379	19	and	and	CC
cord-019001-ralxw4ad	379	20	structural	structural	JJ
cord-019001-ralxw4ad	379	21	derangements	derangement	NNS
cord-019001-ralxw4ad	379	22	of	of	IN
cord-019001-ralxw4ad	379	23	the	the	DT
cord-019001-ralxw4ad	379	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	379	25	vasculature	vasculature	NN
cord-019001-ralxw4ad	379	26	,	,	,
cord-019001-ralxw4ad	379	27	leading	lead	VBG
cord-019001-ralxw4ad	379	28	to	to	IN
cord-019001-ralxw4ad	379	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	379	30	hypertension	hypertension	NN
cord-019001-ralxw4ad	379	31	[	[	-LRB-
cord-019001-ralxw4ad	379	32	254	254	CD
cord-019001-ralxw4ad	379	33	]	]	-RRB-
cord-019001-ralxw4ad	379	34	[	[	-LRB-
cord-019001-ralxw4ad	379	35	255	255	CD
cord-019001-ralxw4ad	379	36	]	]	-RRB-
cord-019001-ralxw4ad	379	37	[	[	-LRB-
cord-019001-ralxw4ad	379	38	256	256	CD
cord-019001-ralxw4ad	379	39	]	]	-RRB-
cord-019001-ralxw4ad	379	40	.	.	.
cord-019001-ralxw4ad	380	1	Fortunately	fortunately	RB
cord-019001-ralxw4ad	380	2	,	,	,
cord-019001-ralxw4ad	380	3	elevations	elevation	NNS
cord-019001-ralxw4ad	380	4	in	in	IN
cord-019001-ralxw4ad	380	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	380	6	arterial	arterial	JJ
cord-019001-ralxw4ad	380	7	pressure	pressure	NN
cord-019001-ralxw4ad	380	8	that	that	WDT
cord-019001-ralxw4ad	380	9	occur	occur	VBP
cord-019001-ralxw4ad	380	10	in	in	IN
cord-019001-ralxw4ad	380	11	response	response	NN
cord-019001-ralxw4ad	380	12	to	to	IN
cord-019001-ralxw4ad	380	13	acute	acute	JJ
cord-019001-ralxw4ad	380	14	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	380	15	(	(	-LRB-
cord-019001-ralxw4ad	380	16	such	such	JJ
cord-019001-ralxw4ad	380	17	as	as	IN
cord-019001-ralxw4ad	380	18	an	an	DT
cord-019001-ralxw4ad	380	19	acute	acute	JJ
cord-019001-ralxw4ad	380	20	ascent	ascent	NN
cord-019001-ralxw4ad	380	21	in	in	IN
cord-019001-ralxw4ad	380	22	altitude	altitude	NN
cord-019001-ralxw4ad	380	23	)	)	-RRB-
cord-019001-ralxw4ad	380	24	are	be	VBP
cord-019001-ralxw4ad	380	25	rapidly	rapidly	RB
cord-019001-ralxw4ad	380	26	reversible	reversible	JJ
cord-019001-ralxw4ad	380	27	.	.	.
cord-019001-ralxw4ad	381	1	Interestingly	interestingly	RB
cord-019001-ralxw4ad	381	2	,	,	,
cord-019001-ralxw4ad	381	3	there	there	EX
cord-019001-ralxw4ad	381	4	is	be	VBZ
cord-019001-ralxw4ad	381	5	great	great	JJ
cord-019001-ralxw4ad	381	6	clinical	clinical	JJ
cord-019001-ralxw4ad	381	7	variability	variability	NN
cord-019001-ralxw4ad	381	8	in	in	IN
cord-019001-ralxw4ad	381	9	the	the	DT
cord-019001-ralxw4ad	381	10	response	response	NN
cord-019001-ralxw4ad	381	11	to	to	IN
cord-019001-ralxw4ad	381	12	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	381	13	.	.	.
cord-019001-ralxw4ad	382	1	For	for	IN
cord-019001-ralxw4ad	382	2	example	example	NN
cord-019001-ralxw4ad	382	3	,	,	,
cord-019001-ralxw4ad	382	4	increased	increase	VBN
cord-019001-ralxw4ad	382	5	susceptibility	susceptibility	NN
cord-019001-ralxw4ad	382	6	to	to	IN
cord-019001-ralxw4ad	382	7	high	high	JJ
cord-019001-ralxw4ad	382	8	-	-	HYPH
cord-019001-ralxw4ad	382	9	altitude	altitude	NN
cord-019001-ralxw4ad	382	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	382	11	edema	edema	NN
cord-019001-ralxw4ad	382	12	,	,	,
cord-019001-ralxw4ad	382	13	which	which	WDT
cord-019001-ralxw4ad	382	14	is	be	VBZ
cord-019001-ralxw4ad	382	15	associated	associate	VBN
cord-019001-ralxw4ad	382	16	with	with	IN
cord-019001-ralxw4ad	382	17	increased	increase	VBN
cord-019001-ralxw4ad	382	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	382	19	arterial	arterial	JJ
cord-019001-ralxw4ad	382	20	pressure	pressure	NN
cord-019001-ralxw4ad	382	21	,	,	,
cord-019001-ralxw4ad	382	22	has	have	VBZ
cord-019001-ralxw4ad	382	23	been	be	VBN
cord-019001-ralxw4ad	382	24	linked	link	VBN
cord-019001-ralxw4ad	382	25	to	to	IN
cord-019001-ralxw4ad	382	26	certain	certain	JJ
cord-019001-ralxw4ad	382	27	major	major	JJ
cord-019001-ralxw4ad	382	28	histocompatibility	histocompatibility	NN
cord-019001-ralxw4ad	382	29	complexes	complex	NNS
cord-019001-ralxw4ad	382	30	[	[	-LRB-
cord-019001-ralxw4ad	382	31	257	257	CD
cord-019001-ralxw4ad	382	32	,	,	,
cord-019001-ralxw4ad	382	33	258	258	CD
cord-019001-ralxw4ad	382	34	]	]	-RRB-
cord-019001-ralxw4ad	382	35	.	.	.
cord-019001-ralxw4ad	383	1	The	the	DT
cord-019001-ralxw4ad	383	2	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	383	3	of	of	IN
cord-019001-ralxw4ad	383	4	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	383	5	-	-	HYPH
cord-019001-ralxw4ad	383	6	induced	induce	VBN
cord-019001-ralxw4ad	383	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	383	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	383	9	continue	continue	VBP
cord-019001-ralxw4ad	383	10	to	to	TO
cord-019001-ralxw4ad	383	11	be	be	VB
cord-019001-ralxw4ad	383	12	an	an	DT
cord-019001-ralxw4ad	383	13	area	area	NN
cord-019001-ralxw4ad	383	14	of	of	IN
cord-019001-ralxw4ad	383	15	intense	intense	JJ
cord-019001-ralxw4ad	383	16	investigation	investigation	NN
cord-019001-ralxw4ad	383	17	.	.	.
cord-019001-ralxw4ad	384	1	To	to	IN
cord-019001-ralxw4ad	384	2	date	date	NN
cord-019001-ralxw4ad	384	3	the	the	DT
cord-019001-ralxw4ad	384	4	precise	precise	JJ
cord-019001-ralxw4ad	384	5	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	384	6	remain	remain	VBP
cord-019001-ralxw4ad	384	7	unclear	unclear	JJ
cord-019001-ralxw4ad	384	8	,	,	,
cord-019001-ralxw4ad	384	9	but	but	CC
cord-019001-ralxw4ad	384	10	it	-PRON-	PRP
cord-019001-ralxw4ad	384	11	is	be	VBZ
cord-019001-ralxw4ad	384	12	known	know	VBN
cord-019001-ralxw4ad	384	13	that	that	IN
cord-019001-ralxw4ad	384	14	a	a	DT
cord-019001-ralxw4ad	384	15	number	number	NN
cord-019001-ralxw4ad	384	16	of	of	IN
cord-019001-ralxw4ad	384	17	endothelial	endothelial	JJ
cord-019001-ralxw4ad	384	18	derived	derive	VBN
cord-019001-ralxw4ad	384	19	factors	factor	NNS
cord-019001-ralxw4ad	384	20	,	,	,
cord-019001-ralxw4ad	384	21	such	such	JJ
cord-019001-ralxw4ad	384	22	as	as	IN
cord-019001-ralxw4ad	384	23	NO	no	RB
cord-019001-ralxw4ad	384	24	,	,	,
cord-019001-ralxw4ad	384	25	ET-1	ET-1	NNP
cord-019001-ralxw4ad	384	26	,	,	,
cord-019001-ralxw4ad	384	27	leukotrienes	leukotriene	NNS
cord-019001-ralxw4ad	384	28	,	,	,
cord-019001-ralxw4ad	384	29	and	and	CC
cord-019001-ralxw4ad	384	30	potassium	potassium	NN
cord-019001-ralxw4ad	384	31	channels	channel	NNS
cord-019001-ralxw4ad	384	32	,	,	,
cord-019001-ralxw4ad	384	33	participate	participate	VB
cord-019001-ralxw4ad	384	34	[	[	-LRB-
cord-019001-ralxw4ad	384	35	10	10	CD
cord-019001-ralxw4ad	384	36	,	,	,
cord-019001-ralxw4ad	384	37	[	[	-LRB-
cord-019001-ralxw4ad	384	38	259	259	CD
cord-019001-ralxw4ad	384	39	]	]	-RRB-
cord-019001-ralxw4ad	384	40	[	[	-LRB-
cord-019001-ralxw4ad	384	41	260	260	CD
cord-019001-ralxw4ad	384	42	]	]	-RRB-
cord-019001-ralxw4ad	384	43	[	[	-LRB-
cord-019001-ralxw4ad	384	44	261	261	CD
cord-019001-ralxw4ad	384	45	]	]	-RRB-
cord-019001-ralxw4ad	384	46	[	[	-LRB-
cord-019001-ralxw4ad	384	47	262	262	CD
cord-019001-ralxw4ad	384	48	]	]	-RRB-
cord-019001-ralxw4ad	384	49	.	.	.
cord-019001-ralxw4ad	385	1	Furthermore	furthermore	RB
cord-019001-ralxw4ad	385	2	,	,	,
cord-019001-ralxw4ad	385	3	additional	additional	JJ
cord-019001-ralxw4ad	385	4	genetic	genetic	JJ
cord-019001-ralxw4ad	385	5	polymorphisms	polymorphism	NNS
cord-019001-ralxw4ad	385	6	are	be	VBP
cord-019001-ralxw4ad	385	7	also	also	RB
cord-019001-ralxw4ad	385	8	under	under	IN
cord-019001-ralxw4ad	385	9	investigation	investigation	NN
cord-019001-ralxw4ad	385	10	.	.	.
cord-019001-ralxw4ad	386	1	Pediatricians	pediatrician	NNS
cord-019001-ralxw4ad	386	2	must	must	MD
cord-019001-ralxw4ad	386	3	consider	consider	VB
cord-019001-ralxw4ad	386	4	this	this	DT
cord-019001-ralxw4ad	386	5	physiology	physiology	NN
cord-019001-ralxw4ad	386	6	in	in	IN
cord-019001-ralxw4ad	386	7	patients	patient	NNS
cord-019001-ralxw4ad	386	8	with	with	IN
cord-019001-ralxw4ad	386	9	conditions	condition	NNS
cord-019001-ralxw4ad	386	10	such	such	JJ
cord-019001-ralxw4ad	386	11	as	as	IN
cord-019001-ralxw4ad	386	12	upper	upper	JJ
cord-019001-ralxw4ad	386	13	airway	airway	NN
cord-019001-ralxw4ad	386	14	obstruction	obstruction	NN
cord-019001-ralxw4ad	386	15	,	,	,
cord-019001-ralxw4ad	386	16	central	central	JJ
cord-019001-ralxw4ad	386	17	hypoventilation	hypoventilation	NN
cord-019001-ralxw4ad	386	18	,	,	,
cord-019001-ralxw4ad	386	19	and	and	CC
cord-019001-ralxw4ad	386	20	neuromuscular	neuromuscular	JJ
cord-019001-ralxw4ad	386	21	disorders	disorder	NNS
cord-019001-ralxw4ad	386	22	that	that	WDT
cord-019001-ralxw4ad	386	23	affect	affect	VBP
cord-019001-ralxw4ad	386	24	ventilation	ventilation	NN
cord-019001-ralxw4ad	386	25	.	.	.
cord-019001-ralxw4ad	387	1	In	in	IN
cord-019001-ralxw4ad	387	2	fact	fact	NN
cord-019001-ralxw4ad	387	3	,	,	,
cord-019001-ralxw4ad	387	4	many	many	JJ
cord-019001-ralxw4ad	387	5	of	of	IN
cord-019001-ralxw4ad	387	6	these	these	DT
cord-019001-ralxw4ad	387	7	patients	patient	NNS
cord-019001-ralxw4ad	387	8	do	do	VBP
cord-019001-ralxw4ad	387	9	develop	develop	VB
cord-019001-ralxw4ad	387	10	evidence	evidence	NN
cord-019001-ralxw4ad	387	11	of	of	IN
cord-019001-ralxw4ad	387	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	387	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	387	14	,	,	,
cord-019001-ralxw4ad	387	15	with	with	IN
cord-019001-ralxw4ad	387	16	right	right	JJ
cord-019001-ralxw4ad	387	17	ventricular	ventricular	JJ
cord-019001-ralxw4ad	387	18	enlargement	enlargement	NN
cord-019001-ralxw4ad	387	19	.	.	.
cord-019001-ralxw4ad	388	1	In	in	IN
cord-019001-ralxw4ad	388	2	most	most	JJS
cord-019001-ralxw4ad	388	3	cases	case	NNS
cord-019001-ralxw4ad	388	4	,	,	,
cord-019001-ralxw4ad	388	5	addressing	address	VBG
cord-019001-ralxw4ad	388	6	the	the	DT
cord-019001-ralxw4ad	388	7	underlying	underlie	VBG
cord-019001-ralxw4ad	388	8	pathology	pathology	NN
cord-019001-ralxw4ad	388	9	is	be	VBZ
cord-019001-ralxw4ad	388	10	curative	curative	JJ
cord-019001-ralxw4ad	388	11	,	,	,
cord-019001-ralxw4ad	388	12	but	but	CC
cord-019001-ralxw4ad	388	13	it	-PRON-	PRP
cord-019001-ralxw4ad	388	14	can	can	MD
cord-019001-ralxw4ad	388	15	take	take	VB
cord-019001-ralxw4ad	388	16	some	some	DT
cord-019001-ralxw4ad	388	17	time	time	NN
cord-019001-ralxw4ad	388	18	to	to	TO
cord-019001-ralxw4ad	388	19	fully	fully	RB
cord-019001-ralxw4ad	388	20	reverse	reverse	VB
cord-019001-ralxw4ad	388	21	the	the	DT
cord-019001-ralxw4ad	388	22	structural	structural	JJ
cord-019001-ralxw4ad	388	23	changes	change	NNS
cord-019001-ralxw4ad	388	24	that	that	WDT
cord-019001-ralxw4ad	388	25	have	have	VBP
cord-019001-ralxw4ad	388	26	occurred	occur	VBN
cord-019001-ralxw4ad	388	27	.	.	.
cord-019001-ralxw4ad	389	1	The	the	DT
cord-019001-ralxw4ad	389	2	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	389	3	of	of	IN
cord-019001-ralxw4ad	389	4	acute	acute	JJ
cord-019001-ralxw4ad	389	5	lung	lung	NN
cord-019001-ralxw4ad	389	6	injury	injury	NN
cord-019001-ralxw4ad	389	7	involves	involve	VBZ
cord-019001-ralxw4ad	389	8	damage	damage	NN
cord-019001-ralxw4ad	389	9	to	to	IN
cord-019001-ralxw4ad	389	10	both	both	CC
cord-019001-ralxw4ad	389	11	the	the	DT
cord-019001-ralxw4ad	389	12	alveolar	alveolar	JJ
cord-019001-ralxw4ad	389	13	epithelium	epithelium	NN
cord-019001-ralxw4ad	389	14	and	and	CC
cord-019001-ralxw4ad	389	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	389	16	vascular	vascular	JJ
cord-019001-ralxw4ad	389	17	endothelium	endothelium	NN
cord-019001-ralxw4ad	389	18	.	.	.
cord-019001-ralxw4ad	390	1	Vascular	vascular	JJ
cord-019001-ralxw4ad	390	2	endothelial	endothelial	JJ
cord-019001-ralxw4ad	390	3	injury	injury	NN
cord-019001-ralxw4ad	390	4	accounts	account	NNS
cord-019001-ralxw4ad	390	5	for	for	IN
cord-019001-ralxw4ad	390	6	key	key	JJ
cord-019001-ralxw4ad	390	7	features	feature	NNS
cord-019001-ralxw4ad	390	8	of	of	IN
cord-019001-ralxw4ad	390	9	acute	acute	JJ
cord-019001-ralxw4ad	390	10	lung	lung	NN
cord-019001-ralxw4ad	390	11	injury	injury	NN
cord-019001-ralxw4ad	390	12	,	,	,
cord-019001-ralxw4ad	390	13	including	include	VBG
cord-019001-ralxw4ad	390	14	intravascular	intravascular	JJ
cord-019001-ralxw4ad	390	15	thrombosis	thrombosis	NN
cord-019001-ralxw4ad	390	16	and	and	CC
cord-019001-ralxw4ad	390	17	capillary	capillary	JJ
cord-019001-ralxw4ad	390	18	permeability	permeability	NN
cord-019001-ralxw4ad	390	19	that	that	WDT
cord-019001-ralxw4ad	390	20	increases	increase	VBZ
cord-019001-ralxw4ad	390	21	alveolar	alveolar	NN
cord-019001-ralxw4ad	390	22	fl	fl	NNP
cord-019001-ralxw4ad	390	23	uid	uid	NN
cord-019001-ralxw4ad	390	24	[	[	-LRB-
cord-019001-ralxw4ad	390	25	263	263	CD
cord-019001-ralxw4ad	390	26	]	]	-RRB-
cord-019001-ralxw4ad	390	27	.	.	.
cord-019001-ralxw4ad	391	1	In	in	IN
cord-019001-ralxw4ad	391	2	fact	fact	NN
cord-019001-ralxw4ad	391	3	,	,	,
cord-019001-ralxw4ad	391	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	391	5	vascular	vascular	JJ
cord-019001-ralxw4ad	391	6	injury	injury	NN
cord-019001-ralxw4ad	391	7	,	,	,
cord-019001-ralxw4ad	391	8	in	in	IN
cord-019001-ralxw4ad	391	9	the	the	DT
cord-019001-ralxw4ad	391	10	setting	setting	NN
cord-019001-ralxw4ad	391	11	of	of	IN
cord-019001-ralxw4ad	391	12	acute	acute	JJ
cord-019001-ralxw4ad	391	13	lung	lung	NN
cord-019001-ralxw4ad	391	14	injury	injury	NN
cord-019001-ralxw4ad	391	15	,	,	,
cord-019001-ralxw4ad	391	16	can	can	MD
cord-019001-ralxw4ad	391	17	lead	lead	VB
cord-019001-ralxw4ad	391	18	to	to	IN
cord-019001-ralxw4ad	391	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	391	20	arterial	arterial	JJ
cord-019001-ralxw4ad	391	21	hypertension	hypertension	NN
cord-019001-ralxw4ad	391	22	,	,	,
cord-019001-ralxw4ad	391	23	resulting	result	VBG
cord-019001-ralxw4ad	391	24	in	in	IN
cord-019001-ralxw4ad	391	25	increased	increase	VBN
cord-019001-ralxw4ad	391	26	intrapulmonary	intrapulmonary	JJ
cord-019001-ralxw4ad	391	27	shunting	shunting	NN
cord-019001-ralxw4ad	391	28	,	,	,
cord-019001-ralxw4ad	391	29	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	391	30	,	,	,
cord-019001-ralxw4ad	391	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	391	32	edema	edema	NN
cord-019001-ralxw4ad	391	33	,	,	,
cord-019001-ralxw4ad	391	34	and	and	CC
cord-019001-ralxw4ad	391	35	right	right	JJ
cord-019001-ralxw4ad	391	36	ventricular	ventricular	JJ
cord-019001-ralxw4ad	391	37	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	391	38	[	[	-LRB-
cord-019001-ralxw4ad	391	39	264	264	CD
cord-019001-ralxw4ad	391	40	]	]	-RRB-
cord-019001-ralxw4ad	391	41	[	[	-LRB-
cord-019001-ralxw4ad	391	42	265	265	CD
cord-019001-ralxw4ad	391	43	]	]	-RRB-
cord-019001-ralxw4ad	391	44	[	[	-LRB-
cord-019001-ralxw4ad	391	45	266	266	CD
cord-019001-ralxw4ad	391	46	]	]	-RRB-
cord-019001-ralxw4ad	391	47	[	[	-LRB-
cord-019001-ralxw4ad	391	48	267	267	CD
cord-019001-ralxw4ad	391	49	]	]	-RRB-
cord-019001-ralxw4ad	391	50	.	.	.
cord-019001-ralxw4ad	392	1	In	in	IN
cord-019001-ralxw4ad	392	2	children	child	NNS
cord-019001-ralxw4ad	392	3	with	with	IN
cord-019001-ralxw4ad	392	4	acute	acute	JJ
cord-019001-ralxw4ad	392	5	lung	lung	NN
cord-019001-ralxw4ad	392	6	injury	injury	NN
cord-019001-ralxw4ad	392	7	,	,	,
cord-019001-ralxw4ad	392	8	persistently	persistently	RB
cord-019001-ralxw4ad	392	9	elevated	elevated	JJ
cord-019001-ralxw4ad	392	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	392	11	arterial	arterial	JJ
cord-019001-ralxw4ad	392	12	pressures	pressure	NNS
cord-019001-ralxw4ad	392	13	have	have	VBP
cord-019001-ralxw4ad	392	14	been	be	VBN
cord-019001-ralxw4ad	392	15	associated	associate	VBN
cord-019001-ralxw4ad	392	16	with	with	IN
cord-019001-ralxw4ad	392	17	worse	bad	JJR
cord-019001-ralxw4ad	392	18	outcomes	outcome	NNS
cord-019001-ralxw4ad	392	19	[	[	-LRB-
cord-019001-ralxw4ad	392	20	268	268	CD
cord-019001-ralxw4ad	392	21	]	]	-RRB-
cord-019001-ralxw4ad	392	22	;	;	:
cord-019001-ralxw4ad	392	23	therefore	therefore	RB
cord-019001-ralxw4ad	392	24	,	,	,
cord-019001-ralxw4ad	392	25	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	392	26	have	have	VBP
cord-019001-ralxw4ad	392	27	been	be	VBN
cord-019001-ralxw4ad	392	28	utilized	utilize	VBN
cord-019001-ralxw4ad	392	29	in	in	IN
cord-019001-ralxw4ad	392	30	the	the	DT
cord-019001-ralxw4ad	392	31	management	management	NN
cord-019001-ralxw4ad	392	32	of	of	IN
cord-019001-ralxw4ad	392	33	these	these	DT
cord-019001-ralxw4ad	392	34	patients	patient	NNS
cord-019001-ralxw4ad	392	35	.	.	.
cord-019001-ralxw4ad	393	1	However	however	RB
cord-019001-ralxw4ad	393	2	,	,	,
cord-019001-ralxw4ad	393	3	intravenous	intravenous	JJ
cord-019001-ralxw4ad	393	4	vasodila	vasodila	NN
cord-019001-ralxw4ad	393	5	-	-	HYPH
cord-019001-ralxw4ad	393	6	tors	tor	NNS
cord-019001-ralxw4ad	393	7	that	that	WDT
cord-019001-ralxw4ad	393	8	dilate	dilate	VBP
cord-019001-ralxw4ad	393	9	both	both	CC
cord-019001-ralxw4ad	393	10	the	the	DT
cord-019001-ralxw4ad	393	11	systemic	systemic	JJ
cord-019001-ralxw4ad	393	12	and	and	CC
cord-019001-ralxw4ad	393	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	393	14	vasculature	vasculature	NN
cord-019001-ralxw4ad	393	15	have	have	VBP
cord-019001-ralxw4ad	393	16	signifi	signifi	NNP
cord-019001-ralxw4ad	393	17	ca	can	MD
cord-019001-ralxw4ad	393	18	nt	not	RB
cord-019001-ralxw4ad	393	19	problems	problem	NNS
cord-019001-ralxw4ad	393	20	,	,	,
cord-019001-ralxw4ad	393	21	including	include	VBG
cord-019001-ralxw4ad	393	22	systemic	systemic	JJ
cord-019001-ralxw4ad	393	23	hypotension	hypotension	NN
cord-019001-ralxw4ad	393	24	,	,	,
cord-019001-ralxw4ad	393	25	right	right	JJ
cord-019001-ralxw4ad	393	26	ventricular	ventricular	JJ
cord-019001-ralxw4ad	393	27	ischemia	ischemia	NN
cord-019001-ralxw4ad	393	28	,	,	,
cord-019001-ralxw4ad	393	29	increased	increase	VBN
cord-019001-ralxw4ad	393	30	intrapulmonary	intrapulmonary	JJ
cord-019001-ralxw4ad	393	31	shunting	shunting	NN
cord-019001-ralxw4ad	393	32	(	(	-LRB-
cord-019001-ralxw4ad	393	33	i.e.	i.e.	FW
cord-019001-ralxw4ad	393	34	,	,	,
cord-019001-ralxw4ad	393	35	increased	increase	VBN
cord-019001-ralxw4ad	393	36	V	v	NN
cord-019001-ralxw4ad	393	37	/	/	SYM
cord-019001-ralxw4ad	393	38	Q	q	NN
cord-019001-ralxw4ad	393	39	mismatch	mismatch	NN
cord-019001-ralxw4ad	393	40	)	)	-RRB-
cord-019001-ralxw4ad	393	41	,	,	,
cord-019001-ralxw4ad	393	42	and	and	CC
cord-019001-ralxw4ad	393	43	increased	increase	VBN
cord-019001-ralxw4ad	393	44	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	393	45	[	[	-LRB-
cord-019001-ralxw4ad	393	46	141	141	CD
cord-019001-ralxw4ad	393	47	]	]	-RRB-
cord-019001-ralxw4ad	393	48	[	[	-LRB-
cord-019001-ralxw4ad	393	49	142	142	CD
cord-019001-ralxw4ad	393	50	]	]	-RRB-
cord-019001-ralxw4ad	393	51	[	[	-LRB-
cord-019001-ralxw4ad	393	52	143	143	CD
cord-019001-ralxw4ad	393	53	]	]	-RRB-
cord-019001-ralxw4ad	393	54	[	[	-LRB-
cord-019001-ralxw4ad	393	55	144	144	CD
cord-019001-ralxw4ad	393	56	]	]	-RRB-
cord-019001-ralxw4ad	393	57	[	[	-LRB-
cord-019001-ralxw4ad	393	58	145	145	CD
cord-019001-ralxw4ad	393	59	]	]	-RRB-
cord-019001-ralxw4ad	393	60	.	.	.
cord-019001-ralxw4ad	394	1	Consequently	consequently	RB
cord-019001-ralxw4ad	394	2	,	,	,
cord-019001-ralxw4ad	394	3	selective	selective	JJ
cord-019001-ralxw4ad	394	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	394	5	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	394	6	with	with	IN
cord-019001-ralxw4ad	394	7	inhaled	inhale	VBN
cord-019001-ralxw4ad	394	8	NO	NO	NNP
cord-019001-ralxw4ad	394	9	has	have	VBZ
cord-019001-ralxw4ad	394	10	been	be	VBN
cord-019001-ralxw4ad	394	11	utilized	utilize	VBN
cord-019001-ralxw4ad	394	12	,	,	,
cord-019001-ralxw4ad	394	13	as	as	IN
cord-019001-ralxw4ad	394	14	it	-PRON-	PRP
cord-019001-ralxw4ad	394	15	improves	improve	VBZ
cord-019001-ralxw4ad	394	16	V	v	NN
cord-019001-ralxw4ad	394	17	/	/	SYM
cord-019001-ralxw4ad	394	18	Q	q	NN
cord-019001-ralxw4ad	394	19	matching	matching	NN
cord-019001-ralxw4ad	394	20	and	and	CC
cord-019001-ralxw4ad	394	21	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	394	22	without	without	IN
cord-019001-ralxw4ad	394	23	untoward	untoward	JJ
cord-019001-ralxw4ad	394	24	systemic	systemic	JJ
cord-019001-ralxw4ad	394	25	effects	effect	NNS
cord-019001-ralxw4ad	394	26	[	[	-LRB-
cord-019001-ralxw4ad	394	27	269	269	CD
cord-019001-ralxw4ad	394	28	,	,	,
cord-019001-ralxw4ad	394	29	270	270	CD
cord-019001-ralxw4ad	394	30	]	]	-RRB-
cord-019001-ralxw4ad	394	31	.	.	.
cord-019001-ralxw4ad	395	1	Unfortunately	unfortunately	RB
cord-019001-ralxw4ad	395	2	,	,	,
cord-019001-ralxw4ad	395	3	improvements	improvement	NNS
cord-019001-ralxw4ad	395	4	in	in	IN
cord-019001-ralxw4ad	395	5	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	395	6	associated	associate	VBN
cord-019001-ralxw4ad	395	7	with	with	IN
cord-019001-ralxw4ad	395	8	inhaled	inhale	VBN
cord-019001-ralxw4ad	395	9	NO	no	DT
cord-019001-ralxw4ad	395	10	are	be	VBP
cord-019001-ralxw4ad	395	11	transient	transient	JJ
cord-019001-ralxw4ad	395	12	,	,	,
cord-019001-ralxw4ad	395	13	and	and	CC
cord-019001-ralxw4ad	395	14	large	large	JJ
cord-019001-ralxw4ad	395	15	randomized	randomized	JJ
cord-019001-ralxw4ad	395	16	trials	trial	NNS
cord-019001-ralxw4ad	395	17	have	have	VBP
cord-019001-ralxw4ad	395	18	failed	fail	VBN
cord-019001-ralxw4ad	395	19	to	to	TO
cord-019001-ralxw4ad	395	20	demonstrate	demonstrate	VB
cord-019001-ralxw4ad	395	21	an	an	DT
cord-019001-ralxw4ad	395	22	improvement	improvement	NN
cord-019001-ralxw4ad	395	23	in	in	IN
cord-019001-ralxw4ad	395	24	mortality	mortality	NN
cord-019001-ralxw4ad	395	25	with	with	IN
cord-019001-ralxw4ad	395	26	its	-PRON-	PRP$
cord-019001-ralxw4ad	395	27	use	use	NN
cord-019001-ralxw4ad	395	28	[	[	-LRB-
cord-019001-ralxw4ad	395	29	120	120	CD
cord-019001-ralxw4ad	395	30	,	,	,
cord-019001-ralxw4ad	395	31	271	271	CD
cord-019001-ralxw4ad	395	32	,	,	,
cord-019001-ralxw4ad	395	33	272	272	CD
cord-019001-ralxw4ad	395	34	]	]	-RRB-
cord-019001-ralxw4ad	395	35	.	.	.
cord-019001-ralxw4ad	396	1	The	the	DT
cord-019001-ralxw4ad	396	2	routine	routine	JJ
cord-019001-ralxw4ad	396	3	use	use	NN
cord-019001-ralxw4ad	396	4	of	of	IN
cord-019001-ralxw4ad	396	5	inhaled	inhale	VBN
cord-019001-ralxw4ad	396	6	NO	no	RB
cord-019001-ralxw4ad	396	7	in	in	IN
cord-019001-ralxw4ad	396	8	patients	patient	NNS
cord-019001-ralxw4ad	396	9	with	with	IN
cord-019001-ralxw4ad	396	10	acute	acute	JJ
cord-019001-ralxw4ad	396	11	lung	lung	NN
cord-019001-ralxw4ad	396	12	injury	injury	NN
cord-019001-ralxw4ad	396	13	,	,	,
cord-019001-ralxw4ad	396	14	therefore	therefore	RB
cord-019001-ralxw4ad	396	15	,	,	,
cord-019001-ralxw4ad	396	16	can	can	MD
cord-019001-ralxw4ad	396	17	not	not	RB
cord-019001-ralxw4ad	396	18	be	be	VB
cord-019001-ralxw4ad	396	19	justifi	justifi	NNP
cord-019001-ralxw4ad	396	20	ed	ed	NN
cord-019001-ralxw4ad	396	21	;	;	:
cord-019001-ralxw4ad	396	22	however	however	RB
cord-019001-ralxw4ad	396	23	,	,	,
cord-019001-ralxw4ad	396	24	it	-PRON-	PRP
cord-019001-ralxw4ad	396	25	may	may	MD
cord-019001-ralxw4ad	396	26	be	be	VB
cord-019001-ralxw4ad	396	27	indicated	indicate	VBN
cord-019001-ralxw4ad	396	28	in	in	IN
cord-019001-ralxw4ad	396	29	individual	individual	JJ
cord-019001-ralxw4ad	396	30	patients	patient	NNS
cord-019001-ralxw4ad	396	31	,	,	,
cord-019001-ralxw4ad	396	32	particularly	particularly	RB
cord-019001-ralxw4ad	396	33	those	those	DT
cord-019001-ralxw4ad	396	34	with	with	IN
cord-019001-ralxw4ad	396	35	an	an	DT
cord-019001-ralxw4ad	396	36	acute	acute	JJ
cord-019001-ralxw4ad	396	37	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	396	38	compromise	compromise	NN
cord-019001-ralxw4ad	396	39	and	and	CC
cord-019001-ralxw4ad	396	40	refractory	refractory	JJ
cord-019001-ralxw4ad	396	41	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	396	42	caused	cause	VBN
cord-019001-ralxw4ad	396	43	by	by	IN
cord-019001-ralxw4ad	396	44	elevated	elevated	JJ
cord-019001-ralxw4ad	396	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	396	46	arterial	arterial	JJ
cord-019001-ralxw4ad	396	47	pressures	pressure	NNS
cord-019001-ralxw4ad	396	48	.	.	.
cord-019001-ralxw4ad	397	1	Clearly	clearly	RB
cord-019001-ralxw4ad	397	2	,	,	,
cord-019001-ralxw4ad	397	3	physicians	physician	NNS
cord-019001-ralxw4ad	397	4	caring	care	VBG
cord-019001-ralxw4ad	397	5	for	for	IN
cord-019001-ralxw4ad	397	6	pediatric	pediatric	JJ
cord-019001-ralxw4ad	397	7	patients	patient	NNS
cord-019001-ralxw4ad	397	8	with	with	IN
cord-019001-ralxw4ad	397	9	acute	acute	JJ
cord-019001-ralxw4ad	397	10	lung	lung	NN
cord-019001-ralxw4ad	397	11	injury	injury	NN
cord-019001-ralxw4ad	397	12	must	must	MD
cord-019001-ralxw4ad	397	13	include	include	VB
cord-019001-ralxw4ad	397	14	an	an	DT
cord-019001-ralxw4ad	397	15	awareness	awareness	NN
cord-019001-ralxw4ad	397	16	of	of	IN
cord-019001-ralxw4ad	397	17	the	the	DT
cord-019001-ralxw4ad	397	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	397	19	vascular	vascular	JJ
cord-019001-ralxw4ad	397	20	aberrations	aberration	NNS
cord-019001-ralxw4ad	397	21	associated	associate	VBN
cord-019001-ralxw4ad	397	22	with	with	IN
cord-019001-ralxw4ad	397	23	the	the	DT
cord-019001-ralxw4ad	397	24	disease	disease	NN
cord-019001-ralxw4ad	397	25	in	in	IN
cord-019001-ralxw4ad	397	26	their	-PRON-	PRP$
cord-019001-ralxw4ad	397	27	management	management	NN
cord-019001-ralxw4ad	397	28	considerations	consideration	NNS
cord-019001-ralxw4ad	397	29	.	.	.
cord-019001-ralxw4ad	398	1	Historically	historically	RB
cord-019001-ralxw4ad	398	2	,	,	,
cord-019001-ralxw4ad	398	3	diseases	disease	NNS
cord-019001-ralxw4ad	398	4	of	of	IN
cord-019001-ralxw4ad	398	5	the	the	DT
cord-019001-ralxw4ad	398	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	398	7	vasculature	vasculature	NN
cord-019001-ralxw4ad	398	8	,	,	,
cord-019001-ralxw4ad	398	9	although	although	IN
cord-019001-ralxw4ad	398	10	not	not	RB
cord-019001-ralxw4ad	398	11	uncommon	uncommon	JJ
cord-019001-ralxw4ad	398	12	,	,	,
cord-019001-ralxw4ad	398	13	have	have	VBP
cord-019001-ralxw4ad	398	14	been	be	VBN
cord-019001-ralxw4ad	398	15	underrecognized	underrecognize	VBN
cord-019001-ralxw4ad	398	16	.	.	.
cord-019001-ralxw4ad	399	1	This	this	DT
cord-019001-ralxw4ad	399	2	was	be	VBD
cord-019001-ralxw4ad	399	3	caused	cause	VBN
cord-019001-ralxw4ad	399	4	,	,	,
cord-019001-ralxw4ad	399	5	in	in	IN
cord-019001-ralxw4ad	399	6	part	part	NN
cord-019001-ralxw4ad	399	7	,	,	,
cord-019001-ralxw4ad	399	8	by	by	IN
cord-019001-ralxw4ad	399	9	the	the	DT
cord-019001-ralxw4ad	399	10	paucity	paucity	NN
cord-019001-ralxw4ad	399	11	of	of	IN
cord-019001-ralxw4ad	399	12	effective	effective	JJ
cord-019001-ralxw4ad	399	13	treatments	treatment	NNS
cord-019001-ralxw4ad	399	14	as	as	RB
cord-019001-ralxw4ad	399	15	well	well	RB
cord-019001-ralxw4ad	399	16	as	as	IN
cord-019001-ralxw4ad	399	17	an	an	DT
cord-019001-ralxw4ad	399	18	incomplete	incomplete	JJ
cord-019001-ralxw4ad	399	19	understanding	understanding	NN
cord-019001-ralxw4ad	399	20	of	of	IN
cord-019001-ralxw4ad	399	21	the	the	DT
cord-019001-ralxw4ad	399	22	vascular	vascular	JJ
cord-019001-ralxw4ad	399	23	biologic	biologic	JJ
cord-019001-ralxw4ad	399	24	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	399	25	.	.	.
cord-019001-ralxw4ad	400	1	In	in	IN
cord-019001-ralxw4ad	400	2	fact	fact	NN
cord-019001-ralxw4ad	400	3	,	,	,
cord-019001-ralxw4ad	400	4	over	over	IN
cord-019001-ralxw4ad	400	5	the	the	DT
cord-019001-ralxw4ad	400	6	past	past	JJ
cord-019001-ralxw4ad	400	7	decade	decade	NN
cord-019001-ralxw4ad	400	8	,	,	,
cord-019001-ralxw4ad	400	9	the	the	DT
cord-019001-ralxw4ad	400	10	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	400	11	gold	gold	NN
cord-019001-ralxw4ad	400	12	standard	standard	NN
cord-019001-ralxw4ad	400	13	has	have	VBZ
cord-019001-ralxw4ad	400	14	been	be	VBN
cord-019001-ralxw4ad	400	15	the	the	DT
cord-019001-ralxw4ad	400	16	continuous	continuous	JJ
cord-019001-ralxw4ad	400	17	infusion	infusion	NN
cord-019001-ralxw4ad	400	18	of	of	IN
cord-019001-ralxw4ad	400	19	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	400	20	.	.	.
cord-019001-ralxw4ad	401	1	Although	although	IN
cord-019001-ralxw4ad	401	2	certainly	certainly	RB
cord-019001-ralxw4ad	401	3	extending	extend	VBG
cord-019001-ralxw4ad	401	4	and	and	CC
cord-019001-ralxw4ad	401	5	improving	improve	VBG
cord-019001-ralxw4ad	401	6	the	the	DT
cord-019001-ralxw4ad	401	7	lives	life	NNS
cord-019001-ralxw4ad	401	8	of	of	IN
cord-019001-ralxw4ad	401	9	many	many	JJ
cord-019001-ralxw4ad	401	10	patients	patient	NNS
cord-019001-ralxw4ad	401	11	,	,	,
cord-019001-ralxw4ad	401	12	intravenous	intravenous	JJ
cord-019001-ralxw4ad	401	13	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	401	14	administration	administration	NNP
cord-019001-ralxw4ad	401	15	has	have	VBZ
cord-019001-ralxw4ad	401	16	been	be	VBN
cord-019001-ralxw4ad	401	17	predominantly	predominantly	RB
cord-019001-ralxw4ad	401	18	limited	limit	VBN
cord-019001-ralxw4ad	401	19	to	to	IN
cord-019001-ralxw4ad	401	20	patients	patient	NNS
cord-019001-ralxw4ad	401	21	with	with	IN
cord-019001-ralxw4ad	401	22	irreversible	irreversible	JJ
cord-019001-ralxw4ad	401	23	disease	disease	NN
cord-019001-ralxw4ad	401	24	,	,	,
cord-019001-ralxw4ad	401	25	given	give	VBN
cord-019001-ralxw4ad	401	26	the	the	DT
cord-019001-ralxw4ad	401	27	inconvenience	inconvenience	NN
cord-019001-ralxw4ad	401	28	and	and	CC
cord-019001-ralxw4ad	401	29	morbidity	morbidity	NN
cord-019001-ralxw4ad	401	30	associated	associate	VBN
cord-019001-ralxw4ad	401	31	with	with	IN
cord-019001-ralxw4ad	401	32	its	-PRON-	PRP$
cord-019001-ralxw4ad	401	33	delivery	delivery	NN
cord-019001-ralxw4ad	401	34	.	.	.
cord-019001-ralxw4ad	402	1	Fortunately	fortunately	RB
cord-019001-ralxw4ad	402	2	,	,	,
cord-019001-ralxw4ad	402	3	an	an	DT
cord-019001-ralxw4ad	402	4	expanded	expand	VBN
cord-019001-ralxw4ad	402	5	understanding	understanding	NN
cord-019001-ralxw4ad	402	6	of	of	IN
cord-019001-ralxw4ad	402	7	the	the	DT
cord-019001-ralxw4ad	402	8	vascular	vascular	JJ
cord-019001-ralxw4ad	402	9	endothelium	endothelium	NN
cord-019001-ralxw4ad	402	10	,	,	,
cord-019001-ralxw4ad	402	11	vascular	vascular	JJ
cord-019001-ralxw4ad	402	12	smooth	smooth	JJ
cord-019001-ralxw4ad	402	13	muscle	muscle	NN
cord-019001-ralxw4ad	402	14	cells	cell	NNS
cord-019001-ralxw4ad	402	15	,	,	,
cord-019001-ralxw4ad	402	16	and	and	CC
cord-019001-ralxw4ad	402	17	the	the	DT
cord-019001-ralxw4ad	402	18	role	role	NN
cord-019001-ralxw4ad	402	19	of	of	IN
cord-019001-ralxw4ad	402	20	their	-PRON-	PRP$
cord-019001-ralxw4ad	402	21	interactions	interaction	NNS
cord-019001-ralxw4ad	402	22	in	in	IN
cord-019001-ralxw4ad	402	23	the	the	DT
cord-019001-ralxw4ad	402	24	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	402	25	of	of	IN
cord-019001-ralxw4ad	402	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	402	27	vascular	vascular	JJ
cord-019001-ralxw4ad	402	28	disease	disease	NN
cord-019001-ralxw4ad	402	29	have	have	VBP
cord-019001-ralxw4ad	402	30	resulted	result	VBN
cord-019001-ralxw4ad	402	31	in	in	IN
cord-019001-ralxw4ad	402	32	new	new	JJ
cord-019001-ralxw4ad	402	33	effective	effective	JJ
cord-019001-ralxw4ad	402	34	treatments	treatment	NNS
cord-019001-ralxw4ad	402	35	,	,	,
cord-019001-ralxw4ad	402	36	with	with	IN
cord-019001-ralxw4ad	402	37	additional	additional	JJ
cord-019001-ralxw4ad	402	38	potential	potential	JJ
cord-019001-ralxw4ad	402	39	therapies	therapy	NNS
cord-019001-ralxw4ad	402	40	evolving	evolve	VBG
cord-019001-ralxw4ad	402	41	rapidly	rapidly	RB
cord-019001-ralxw4ad	402	42	.	.	.
cord-019001-ralxw4ad	403	1	Oral	oral	JJ
cord-019001-ralxw4ad	403	2	agents	agent	NNS
cord-019001-ralxw4ad	403	3	such	such	JJ
cord-019001-ralxw4ad	403	4	as	as	IN
cord-019001-ralxw4ad	403	5	bosentan	bosentan	NNP
cord-019001-ralxw4ad	403	6	and	and	CC
cord-019001-ralxw4ad	403	7	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	403	8	l	l	NNP
cord-019001-ralxw4ad	403	9	are	be	VBP
cord-019001-ralxw4ad	403	10	two	two	CD
cord-019001-ralxw4ad	403	11	examples	example	NNS
cord-019001-ralxw4ad	403	12	with	with	IN
cord-019001-ralxw4ad	403	13	great	great	JJ
cord-019001-ralxw4ad	403	14	promise	promise	NN
cord-019001-ralxw4ad	403	15	.	.	.
cord-019001-ralxw4ad	404	1	In	in	IN
cord-019001-ralxw4ad	404	2	addition	addition	NN
cord-019001-ralxw4ad	404	3	,	,	,
cord-019001-ralxw4ad	404	4	accumulated	accumulate	VBN
cord-019001-ralxw4ad	404	5	experience	experience	NN
cord-019001-ralxw4ad	404	6	and	and	CC
cord-019001-ralxw4ad	404	7	focused	focused	JJ
cord-019001-ralxw4ad	404	8	research	research	NN
cord-019001-ralxw4ad	404	9	have	have	VBP
cord-019001-ralxw4ad	404	10	uncovered	uncover	VBN
cord-019001-ralxw4ad	404	11	a	a	DT
cord-019001-ralxw4ad	404	12	multitude	multitude	NN
cord-019001-ralxw4ad	404	13	of	of	IN
cord-019001-ralxw4ad	404	14	disease	disease	NN
cord-019001-ralxw4ad	404	15	processes	process	NNS
cord-019001-ralxw4ad	404	16	that	that	WDT
cord-019001-ralxw4ad	404	17	contribute	contribute	VBP
cord-019001-ralxw4ad	404	18	directly	directly	RB
cord-019001-ralxw4ad	404	19	or	or	CC
cord-019001-ralxw4ad	404	20	indirectly	indirectly	RB
cord-019001-ralxw4ad	404	21	to	to	IN
cord-019001-ralxw4ad	404	22	the	the	DT
cord-019001-ralxw4ad	404	23	development	development	NN
cord-019001-ralxw4ad	404	24	of	of	IN
cord-019001-ralxw4ad	404	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	404	26	hypertension	hypertension	NN
cord-019001-ralxw4ad	404	27	.	.	.
cord-019001-ralxw4ad	405	1	Physicians	physician	NNS
cord-019001-ralxw4ad	405	2	caring	care	VBG
cord-019001-ralxw4ad	405	3	for	for	IN
cord-019001-ralxw4ad	405	4	critically	critically	RB
cord-019001-ralxw4ad	405	5	ill	ill	JJ
cord-019001-ralxw4ad	405	6	children	child	NNS
cord-019001-ralxw4ad	405	7	must	must	MD
cord-019001-ralxw4ad	405	8	be	be	VB
cord-019001-ralxw4ad	405	9	aware	aware	JJ
cord-019001-ralxw4ad	405	10	of	of	IN
cord-019001-ralxw4ad	405	11	these	these	DT
cord-019001-ralxw4ad	405	12	illnesses	illness	NNS
cord-019001-ralxw4ad	405	13	,	,	,
cord-019001-ralxw4ad	405	14	the	the	DT
cord-019001-ralxw4ad	405	15	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	405	16	of	of	IN
cord-019001-ralxw4ad	405	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	405	18	hypertension	hypertension	NN
cord-019001-ralxw4ad	405	19	,	,	,
cord-019001-ralxw4ad	405	20	and	and	CC
cord-019001-ralxw4ad	405	21	the	the	DT
cord-019001-ralxw4ad	405	22	available	available	JJ
cord-019001-ralxw4ad	405	23	treatment	treatment	NN
cord-019001-ralxw4ad	405	24	options	option	NNS
cord-019001-ralxw4ad	405	25	in	in	IN
cord-019001-ralxw4ad	405	26	order	order	NN
cord-019001-ralxw4ad	405	27	to	to	TO
cord-019001-ralxw4ad	405	28	translate	translate	VB
cord-019001-ralxw4ad	405	29	these	these	DT
cord-019001-ralxw4ad	405	30	advances	advance	NNS
cord-019001-ralxw4ad	405	31	into	into	IN
cord-019001-ralxw4ad	405	32	improved	improved	JJ
cord-019001-ralxw4ad	405	33	outcomes	outcome	NNS
cord-019001-ralxw4ad	405	34	for	for	IN
cord-019001-ralxw4ad	405	35	patients	patient	NNS
cord-019001-ralxw4ad	405	36	.	.	.
cord-019001-ralxw4ad	406	1	Cultured	cultured	JJ
cord-019001-ralxw4ad	406	2	endothelial	endothelial	JJ
cord-019001-ralxw4ad	406	3	cells	cell	NNS
cord-019001-ralxw4ad	406	4	synthesize	synthesize	VBP
cord-019001-ralxw4ad	406	5	both	both	DT
cord-019001-ralxw4ad	406	6	platelet	platelet	NN
cord-019001-ralxw4ad	406	7	-	-	HYPH
cord-019001-ralxw4ad	406	8	activating	activate	VBG
cord-019001-ralxw4ad	406	9	factor	factor	NN
cord-019001-ralxw4ad	406	10	and	and	CC
cord-019001-ralxw4ad	406	11	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	406	12	in	in	IN
cord-019001-ralxw4ad	406	13	response	response	NN
cord-019001-ralxw4ad	406	14	to	to	IN
cord-019001-ralxw4ad	406	15	histamine	histamine	NN
cord-019001-ralxw4ad	406	16	,	,	,
cord-019001-ralxw4ad	406	17	bradykinin	bradykinin	NN
cord-019001-ralxw4ad	406	18	,	,	,
cord-019001-ralxw4ad	406	19	and	and	CC
cord-019001-ralxw4ad	406	20	adenosine	adenosine	NN
cord-019001-ralxw4ad	406	21	triphosphate	triphosphate	NN
cord-019001-ralxw4ad	407	1	A	a	DT
cord-019001-ralxw4ad	407	2	novel	novel	JJ
cord-019001-ralxw4ad	407	3	potent	potent	JJ
cord-019001-ralxw4ad	407	4	vasoconstrictor	vasoconstrictor	NN
cord-019001-ralxw4ad	407	5	peptide	peptide	NN
cord-019001-ralxw4ad	407	6	produced	produce	VBN
cord-019001-ralxw4ad	407	7	by	by	IN
cord-019001-ralxw4ad	407	8	vascular	vascular	JJ
cord-019001-ralxw4ad	407	9	endothelial	endothelial	JJ
cord-019001-ralxw4ad	407	10	cells	cell	NNS
cord-019001-ralxw4ad	408	1	Vascular	vascular	JJ
cord-019001-ralxw4ad	408	2	endothelial	endothelial	JJ
cord-019001-ralxw4ad	408	3	cells	cell	NNS
cord-019001-ralxw4ad	408	4	synthesize	synthesize	VBP
cord-019001-ralxw4ad	408	5	nitric	nitric	JJ
cord-019001-ralxw4ad	408	6	oxide	oxide	NN
cord-019001-ralxw4ad	408	7	from	from	IN
cord-019001-ralxw4ad	408	8	L	l	NN
cord-019001-ralxw4ad	408	9	-	-	HYPH
cord-019001-ralxw4ad	408	10	arginine	arginine	NNP
cord-019001-ralxw4ad	408	11	Flow	flow	NN
cord-019001-ralxw4ad	408	12	-	-	HYPH
cord-019001-ralxw4ad	408	13	induced	induce	VBN
cord-019001-ralxw4ad	408	14	release	release	NN
cord-019001-ralxw4ad	408	15	of	of	IN
cord-019001-ralxw4ad	408	16	endothelium	endothelium	NN
cord-019001-ralxw4ad	408	17	-	-	HYPH
cord-019001-ralxw4ad	408	18	derived	derive	VBN
cord-019001-ralxw4ad	408	19	relaxing	relaxing	NN
cord-019001-ralxw4ad	408	20	factor	factor	NN
cord-019001-ralxw4ad	408	21	Molecular	molecular	JJ
cord-019001-ralxw4ad	408	22	mechanisms	mechanism	NNS
cord-019001-ralxw4ad	408	23	of	of	IN
cord-019001-ralxw4ad	408	24	endothelium	endothelium	NN
cord-019001-ralxw4ad	408	25	-	-	HYPH
cord-019001-ralxw4ad	408	26	mediated	mediate	VBN
cord-019001-ralxw4ad	408	27	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	409	1	The	the	DT
cord-019001-ralxw4ad	409	2	L	l	NN
cord-019001-ralxw4ad	409	3	-	-	HYPH
cord-019001-ralxw4ad	409	4	arginine	arginine	NN
cord-019001-ralxw4ad	409	5	-	-	HYPH
cord-019001-ralxw4ad	409	6	nitric	nitric	NN
cord-019001-ralxw4ad	409	7	oxide	oxide	NN
cord-019001-ralxw4ad	409	8	pathway	pathway	NN
cord-019001-ralxw4ad	409	9	N	n	CD
cord-019001-ralxw4ad	409	10	omega	omega	NN
cord-019001-ralxw4ad	409	11	-	-	HYPH
cord-019001-ralxw4ad	409	12	nitro	nitro	NN
cord-019001-ralxw4ad	409	13	-	-	HYPH
cord-019001-ralxw4ad	409	14	L	l	NN
cord-019001-ralxw4ad	409	15	-	-	HYPH
cord-019001-ralxw4ad	409	16	arginine	arginine	NN
cord-019001-ralxw4ad	409	17	attenuates	attenuate	VBZ
cord-019001-ralxw4ad	409	18	endothelium	endothelium	NN
cord-019001-ralxw4ad	409	19	-	-	HYPH
cord-019001-ralxw4ad	409	20	dependent	dependent	JJ
cord-019001-ralxw4ad	409	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	409	22	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	409	23	in	in	IN
cord-019001-ralxw4ad	409	24	lambs	lamb	NNS
cord-019001-ralxw4ad	409	25	Endothelial	endothelial	JJ
cord-019001-ralxw4ad	409	26	modulation	modulation	NN
cord-019001-ralxw4ad	409	27	of	of	IN
cord-019001-ralxw4ad	409	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	409	29	vascular	vascular	JJ
cord-019001-ralxw4ad	409	30	tone	tone	NN
cord-019001-ralxw4ad	409	31	Nitric	nitric	NN
cord-019001-ralxw4ad	409	32	oxide	oxide	NN
cord-019001-ralxw4ad	409	33	-	-	HYPH
cord-019001-ralxw4ad	409	34	generating	generate	VBG
cord-019001-ralxw4ad	409	35	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	409	36	and	and	CC
cord-019001-ralxw4ad	410	1	8-bromo	8-bromo	CD
cord-019001-ralxw4ad	410	2	-	-	HYPH
cord-019001-ralxw4ad	410	3	cyclic	cyclic	JJ
cord-019001-ralxw4ad	410	4	guanosine	guanosine	NN
cord-019001-ralxw4ad	410	5	monophosphate	monophosphate	NN
cord-019001-ralxw4ad	411	1	inhibit	inhibit	VB
cord-019001-ralxw4ad	411	2	mitogenesis	mitogenesis	NN
cord-019001-ralxw4ad	411	3	and	and	CC
cord-019001-ralxw4ad	411	4	proliferation	proliferation	NN
cord-019001-ralxw4ad	411	5	of	of	IN
cord-019001-ralxw4ad	411	6	cultured	cultured	JJ
cord-019001-ralxw4ad	411	7	rat	rat	NN
cord-019001-ralxw4ad	411	8	vascular	vascular	JJ
cord-019001-ralxw4ad	411	9	smooth	smooth	JJ
cord-019001-ralxw4ad	411	10	muscle	muscle	NN
cord-019001-ralxw4ad	411	11	cells	cell	NNS
cord-019001-ralxw4ad	411	12	EDRF	EDRF	NNP
cord-019001-ralxw4ad	411	13	inhibition	inhibition	NN
cord-019001-ralxw4ad	411	14	augments	augment	VBZ
cord-019001-ralxw4ad	411	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	411	16	hypertension	hypertension	NN
cord-019001-ralxw4ad	411	17	in	in	IN
cord-019001-ralxw4ad	411	18	intact	intact	JJ
cord-019001-ralxw4ad	411	19	newborn	newborn	JJ
cord-019001-ralxw4ad	411	20	lambs	lamb	NNS
cord-019001-ralxw4ad	412	1	In	in	IN
cord-019001-ralxw4ad	412	2	vivo	vivo	NN
cord-019001-ralxw4ad	412	3	attenuation	attenuation	NN
cord-019001-ralxw4ad	412	4	of	of	IN
cord-019001-ralxw4ad	412	5	endothelium	endothelium	NN
cord-019001-ralxw4ad	412	6	-	-	HYPH
cord-019001-ralxw4ad	412	7	dependent	dependent	JJ
cord-019001-ralxw4ad	412	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	412	9	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	412	10	by	by	IN
cord-019001-ralxw4ad	412	11	methylene	methylene	NN
cord-019001-ralxw4ad	412	12	blue	blue	JJ
cord-019001-ralxw4ad	412	13	M&B	M&B	NNP
cord-019001-ralxw4ad	412	14	22948	22948	CD
cord-019001-ralxw4ad	412	15	,	,	,
cord-019001-ralxw4ad	412	16	a	a	DT
cord-019001-ralxw4ad	412	17	cGMP	cGMP	NNP
cord-019001-ralxw4ad	412	18	phosphodiesterase	phosphodiesterase	NN
cord-019001-ralxw4ad	412	19	inhibitor	inhibitor	NN
cord-019001-ralxw4ad	412	20	,	,	,
cord-019001-ralxw4ad	412	21	is	be	VBZ
cord-019001-ralxw4ad	412	22	a	a	DT
cord-019001-ralxw4ad	412	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	412	24	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	412	25	in	in	IN
cord-019001-ralxw4ad	412	26	lambs	lamb	NNS
cord-019001-ralxw4ad	412	27	Nitric	Nitric	NNP
cord-019001-ralxw4ad	412	28	oxide	oxide	NN
cord-019001-ralxw4ad	412	29	regulates	regulate	VBZ
cord-019001-ralxw4ad	412	30	the	the	DT
cord-019001-ralxw4ad	412	31	expression	expression	NN
cord-019001-ralxw4ad	412	32	of	of	IN
cord-019001-ralxw4ad	412	33	vasoconstrictors	vasoconstrictor	NNS
cord-019001-ralxw4ad	412	34	and	and	CC
cord-019001-ralxw4ad	412	35	growth	growth	NN
cord-019001-ralxw4ad	412	36	factors	factor	NNS
cord-019001-ralxw4ad	412	37	by	by	IN
cord-019001-ralxw4ad	412	38	vascular	vascular	JJ
cord-019001-ralxw4ad	412	39	endothelium	endothelium	NN
cord-019001-ralxw4ad	412	40	under	under	IN
cord-019001-ralxw4ad	412	41	both	both	DT
cord-019001-ralxw4ad	412	42	normoxia	normoxia	NN
cord-019001-ralxw4ad	412	43	and	and	CC
cord-019001-ralxw4ad	412	44	hypoxia	hypoxia	VB
cord-019001-ralxw4ad	412	45	Endothelial	endothelial	JJ
cord-019001-ralxw4ad	412	46	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	412	47	in	in	IN
cord-019001-ralxw4ad	412	48	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	412	49	hypertension	hypertension	NN
cord-019001-ralxw4ad	413	1	Vascular	vascular	JJ
cord-019001-ralxw4ad	413	2	endothelial	endothelial	JJ
cord-019001-ralxw4ad	413	3	growth	growth	NN
cord-019001-ralxw4ad	413	4	factor	factor	NN
cord-019001-ralxw4ad	413	5	increases	increase	VBZ
cord-019001-ralxw4ad	413	6	endothelinconverting	endothelinconverting	NN
cord-019001-ralxw4ad	413	7	enzyme	enzyme	NN
cord-019001-ralxw4ad	413	8	expression	expression	NN
cord-019001-ralxw4ad	413	9	in	in	IN
cord-019001-ralxw4ad	413	10	vascular	vascular	JJ
cord-019001-ralxw4ad	413	11	endothelial	endothelial	JJ
cord-019001-ralxw4ad	413	12	cells	cell	NNS
cord-019001-ralxw4ad	413	13	Tone	tone	NN
cord-019001-ralxw4ad	413	14	-	-	HYPH
cord-019001-ralxw4ad	413	15	dependent	dependent	JJ
cord-019001-ralxw4ad	413	16	responses	response	NNS
cord-019001-ralxw4ad	413	17	to	to	IN
cord-019001-ralxw4ad	413	18	endothelin	endothelin	VB
cord-019001-ralxw4ad	413	19	in	in	IN
cord-019001-ralxw4ad	413	20	the	the	DT
cord-019001-ralxw4ad	413	21	isolated	isolated	JJ
cord-019001-ralxw4ad	413	22	perfused	perfuse	VBN
cord-019001-ralxw4ad	413	23	fetal	fetal	JJ
cord-019001-ralxw4ad	413	24	sheep	sheep	NN
cord-019001-ralxw4ad	413	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	413	26	circulation	circulation	NN
cord-019001-ralxw4ad	413	27	in	in	IN
cord-019001-ralxw4ad	413	28	situ	situ	VBG
cord-019001-ralxw4ad	413	29	Endothelin-1	Endothelin-1	NNP
cord-019001-ralxw4ad	413	30	produces	produce	VBZ
cord-019001-ralxw4ad	413	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	413	32	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	413	33	in	in	IN
cord-019001-ralxw4ad	413	34	the	the	DT
cord-019001-ralxw4ad	413	35	intact	intact	JJ
cord-019001-ralxw4ad	413	36	newborn	newborn	JJ
cord-019001-ralxw4ad	413	37	lamb	lamb	NN
cord-019001-ralxw4ad	413	38	Developmental	developmental	JJ
cord-019001-ralxw4ad	413	39	effects	effect	NNS
cord-019001-ralxw4ad	413	40	of	of	IN
cord-019001-ralxw4ad	413	41	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	413	42	on	on	IN
cord-019001-ralxw4ad	413	43	the	the	DT
cord-019001-ralxw4ad	413	44	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	413	45	circulation	circulation	NN
cord-019001-ralxw4ad	413	46	in	in	IN
cord-019001-ralxw4ad	413	47	sheep	sheep	NN
cord-019001-ralxw4ad	413	48	Circulatory	circulatory	JJ
cord-019001-ralxw4ad	413	49	effects	effect	NNS
cord-019001-ralxw4ad	413	50	of	of	IN
cord-019001-ralxw4ad	413	51	endothelin	endothelin	NN
cord-019001-ralxw4ad	413	52	in	in	IN
cord-019001-ralxw4ad	413	53	newborn	newborn	JJ
cord-019001-ralxw4ad	413	54	piglets	piglet	NNS
cord-019001-ralxw4ad	414	1	Maturational	Maturational	NNP
cord-019001-ralxw4ad	414	2	changes	change	NNS
cord-019001-ralxw4ad	414	3	in	in	IN
cord-019001-ralxw4ad	414	4	endothelium	endothelium	NN
cord-019001-ralxw4ad	414	5	-	-	HYPH
cord-019001-ralxw4ad	414	6	derived	derive	VBN
cord-019001-ralxw4ad	414	7	relaxations	relaxation	NNS
cord-019001-ralxw4ad	414	8	in	in	IN
cord-019001-ralxw4ad	414	9	newborn	newborn	JJ
cord-019001-ralxw4ad	414	10	piglet	piglet	NN
cord-019001-ralxw4ad	414	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	414	12	circulation	circulation	NN
cord-019001-ralxw4ad	414	13	Circulatory	circulatory	JJ
cord-019001-ralxw4ad	414	14	changes	change	NNS
cord-019001-ralxw4ad	414	15	during	during	IN
cord-019001-ralxw4ad	414	16	growth	growth	NN
cord-019001-ralxw4ad	414	17	in	in	IN
cord-019001-ralxw4ad	414	18	the	the	DT
cord-019001-ralxw4ad	414	19	fetal	fetal	JJ
cord-019001-ralxw4ad	414	20	lamb	lamb	NN
cord-019001-ralxw4ad	414	21	Impairment	Impairment	NNP
cord-019001-ralxw4ad	414	22	of	of	IN
cord-019001-ralxw4ad	414	23	endotheliumdependent	endotheliumdependent	JJ
cord-019001-ralxw4ad	414	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	414	25	artery	artery	NN
cord-019001-ralxw4ad	414	26	relaxation	relaxation	NN
cord-019001-ralxw4ad	414	27	in	in	IN
cord-019001-ralxw4ad	414	28	children	child	NNS
cord-019001-ralxw4ad	414	29	with	with	IN
cord-019001-ralxw4ad	414	30	congenital	congenital	JJ
cord-019001-ralxw4ad	414	31	heart	heart	NN
cord-019001-ralxw4ad	414	32	disease	disease	NN
cord-019001-ralxw4ad	414	33	and	and	CC
cord-019001-ralxw4ad	415	1	abnormal	abnormal	JJ
cord-019001-ralxw4ad	415	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	415	3	hemodynamics	hemodynamic	NNS
cord-019001-ralxw4ad	415	4	Reduced	reduce	VBN
cord-019001-ralxw4ad	415	5	expression	expression	NN
cord-019001-ralxw4ad	415	6	of	of	IN
cord-019001-ralxw4ad	415	7	endothelial	endothelial	JJ
cord-019001-ralxw4ad	415	8	nitric	nitric	NN
cord-019001-ralxw4ad	415	9	oxide	oxide	NN
cord-019001-ralxw4ad	415	10	synthase	synthase	NN
cord-019001-ralxw4ad	415	11	in	in	IN
cord-019001-ralxw4ad	415	12	the	the	DT
cord-019001-ralxw4ad	415	13	lungs	lung	NNS
cord-019001-ralxw4ad	415	14	of	of	IN
cord-019001-ralxw4ad	415	15	patients	patient	NNS
cord-019001-ralxw4ad	415	16	with	with	IN
cord-019001-ralxw4ad	415	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	415	18	hypertension	hypertension	NN
cord-019001-ralxw4ad	415	19	Expression	expression	NN
cord-019001-ralxw4ad	415	20	of	of	IN
cord-019001-ralxw4ad	415	21	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	415	22	in	in	IN
cord-019001-ralxw4ad	415	23	the	the	DT
cord-019001-ralxw4ad	415	24	lungs	lung	NNS
cord-019001-ralxw4ad	415	25	of	of	IN
cord-019001-ralxw4ad	415	26	patients	patient	NNS
cord-019001-ralxw4ad	415	27	with	with	IN
cord-019001-ralxw4ad	415	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	415	29	hypertension	hypertension	NN
cord-019001-ralxw4ad	416	1	Altered	altered	JJ
cord-019001-ralxw4ad	416	2	endothelium	endothelium	NN
cord-019001-ralxw4ad	416	3	-	-	HYPH
cord-019001-ralxw4ad	416	4	dependent	dependent	JJ
cord-019001-ralxw4ad	416	5	responses	response	NNS
cord-019001-ralxw4ad	416	6	in	in	IN
cord-019001-ralxw4ad	416	7	lambs	lamb	NNS
cord-019001-ralxw4ad	416	8	with	with	IN
cord-019001-ralxw4ad	416	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	416	10	hypertension	hypertension	NN
cord-019001-ralxw4ad	416	11	and	and	CC
cord-019001-ralxw4ad	416	12	increased	increase	VBN
cord-019001-ralxw4ad	416	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	416	14	blood	blood	NN
cord-019001-ralxw4ad	417	1	fl	fl	NNP
cord-019001-ralxw4ad	418	1	ow	ow	UH
cord-019001-ralxw4ad	419	1	Morphological	morphological	JJ
cord-019001-ralxw4ad	419	2	development	development	NN
cord-019001-ralxw4ad	419	3	of	of	IN
cord-019001-ralxw4ad	419	4	the	the	DT
cord-019001-ralxw4ad	419	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	419	6	vascular	vascular	JJ
cord-019001-ralxw4ad	419	7	bed	bed	NN
cord-019001-ralxw4ad	419	8	in	in	IN
cord-019001-ralxw4ad	419	9	fetal	fetal	JJ
cord-019001-ralxw4ad	419	10	lambs	lamb	NNS
cord-019001-ralxw4ad	419	11	Effects	effect	NNS
cord-019001-ralxw4ad	419	12	of	of	IN
cord-019001-ralxw4ad	419	13	birth	birth	NN
cord-019001-ralxw4ad	419	14	-	-	HYPH
cord-019001-ralxw4ad	419	15	related	relate	VBN
cord-019001-ralxw4ad	419	16	events	event	NNS
cord-019001-ralxw4ad	419	17	on	on	IN
cord-019001-ralxw4ad	419	18	blood	blood	NN
cord-019001-ralxw4ad	419	19	fl	fl	JJ
cord-019001-ralxw4ad	419	20	ow	ow	NN
cord-019001-ralxw4ad	419	21	distribution	distribution	NN
cord-019001-ralxw4ad	419	22	Fetal	fetal	JJ
cord-019001-ralxw4ad	419	23	and	and	CC
cord-019001-ralxw4ad	419	24	neonatal	neonatal	JJ
cord-019001-ralxw4ad	419	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	419	26	circulation	circulation	NN
cord-019001-ralxw4ad	419	27	Changes	change	NNS
cord-019001-ralxw4ad	419	28	in	in	IN
cord-019001-ralxw4ad	419	29	the	the	DT
cord-019001-ralxw4ad	419	30	lungs	lung	NNS
cord-019001-ralxw4ad	419	31	of	of	IN
cord-019001-ralxw4ad	419	32	the	the	DT
cord-019001-ralxw4ad	419	33	new	new	RB
cord-019001-ralxw4ad	419	34	-	-	HYPH
cord-019001-ralxw4ad	419	35	born	bear	VBN
cord-019001-ralxw4ad	419	36	lamb	lamb	NNP
cord-019001-ralxw4ad	419	37	Control	Control	NNP
cord-019001-ralxw4ad	419	38	of	of	IN
cord-019001-ralxw4ad	419	39	the	the	DT
cord-019001-ralxw4ad	419	40	fetal	fetal	JJ
cord-019001-ralxw4ad	419	41	and	and	CC
cord-019001-ralxw4ad	419	42	neonatal	neonatal	JJ
cord-019001-ralxw4ad	419	43	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	419	44	circulation	circulation	NN
cord-019001-ralxw4ad	419	45	Distribution	distribution	NN
cord-019001-ralxw4ad	419	46	and	and	CC
cord-019001-ralxw4ad	419	47	regulation	regulation	NN
cord-019001-ralxw4ad	419	48	of	of	IN
cord-019001-ralxw4ad	419	49	blood	blood	NN
cord-019001-ralxw4ad	419	50	fl	fl	NNP
cord-019001-ralxw4ad	419	51	ow	ow	NN
cord-019001-ralxw4ad	419	52	in	in	IN
cord-019001-ralxw4ad	419	53	the	the	DT
cord-019001-ralxw4ad	419	54	fetal	fetal	JJ
cord-019001-ralxw4ad	419	55	and	and	CC
cord-019001-ralxw4ad	419	56	neonatal	neonatal	JJ
cord-019001-ralxw4ad	419	57	lamb	lamb	NN
cord-019001-ralxw4ad	419	58	Regulation	regulation	NN
cord-019001-ralxw4ad	419	59	of	of	IN
cord-019001-ralxw4ad	419	60	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	419	61	vascular	vascular	JJ
cord-019001-ralxw4ad	419	62	tone	tone	NN
cord-019001-ralxw4ad	419	63	in	in	IN
cord-019001-ralxw4ad	419	64	the	the	DT
cord-019001-ralxw4ad	419	65	perinatal	perinatal	JJ
cord-019001-ralxw4ad	419	66	period	period	NN
cord-019001-ralxw4ad	419	67	Effect	effect	NN
cord-019001-ralxw4ad	419	68	of	of	IN
cord-019001-ralxw4ad	419	69	lung	lung	NN
cord-019001-ralxw4ad	419	70	expansion	expansion	NN
cord-019001-ralxw4ad	419	71	on	on	IN
cord-019001-ralxw4ad	419	72	the	the	DT
cord-019001-ralxw4ad	419	73	fetal	fetal	JJ
cord-019001-ralxw4ad	419	74	lamb	lamb	NN
cord-019001-ralxw4ad	419	75	circulation	circulation	NN
cord-019001-ralxw4ad	420	1	The	the	DT
cord-019001-ralxw4ad	420	2	onset	onset	NN
cord-019001-ralxw4ad	420	3	of	of	IN
cord-019001-ralxw4ad	420	4	breathing	breathing	NN
cord-019001-ralxw4ad	420	5	at	at	IN
cord-019001-ralxw4ad	420	6	birth	birth	NN
cord-019001-ralxw4ad	420	7	stimulates	stimulate	VBZ
cord-019001-ralxw4ad	420	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	420	9	vascular	vascular	JJ
cord-019001-ralxw4ad	420	10	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	420	11	synthesis	synthesis	NN
cord-019001-ralxw4ad	421	1	Increasing	increase	VBG
cord-019001-ralxw4ad	421	2	oxygen	oxygen	NN
cord-019001-ralxw4ad	421	3	tension	tension	NN
cord-019001-ralxw4ad	421	4	dilates	dilate	VBZ
cord-019001-ralxw4ad	421	5	fetal	fetal	JJ
cord-019001-ralxw4ad	421	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	421	7	circulation	circulation	NN
cord-019001-ralxw4ad	421	8	via	via	IN
cord-019001-ralxw4ad	421	9	endothelium	endothelium	NN
cord-019001-ralxw4ad	421	10	-	-	HYPH
cord-019001-ralxw4ad	421	11	derived	derive	VBN
cord-019001-ralxw4ad	421	12	relaxing	relaxing	NN
cord-019001-ralxw4ad	421	13	factor	factor	NN
cord-019001-ralxw4ad	422	1	Oxygen	oxygen	NN
cord-019001-ralxw4ad	422	2	modulates	modulate	VBZ
cord-019001-ralxw4ad	422	3	endotheliumderived	endotheliumderive	VBN
cord-019001-ralxw4ad	422	4	relaxing	relaxing	JJ
cord-019001-ralxw4ad	422	5	factor	factor	NN
cord-019001-ralxw4ad	422	6	production	production	NN
cord-019001-ralxw4ad	422	7	in	in	IN
cord-019001-ralxw4ad	422	8	fetal	fetal	JJ
cord-019001-ralxw4ad	422	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	422	10	arteries	artery	NNS
cord-019001-ralxw4ad	423	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	423	2	endothelial	endothelial	JJ
cord-019001-ralxw4ad	423	3	nitric	nitric	NN
cord-019001-ralxw4ad	423	4	oxide	oxide	NN
cord-019001-ralxw4ad	423	5	production	production	NN
cord-019001-ralxw4ad	423	6	is	be	VBZ
cord-019001-ralxw4ad	423	7	developmentally	developmentally	RB
cord-019001-ralxw4ad	423	8	regulated	regulate	VBN
cord-019001-ralxw4ad	423	9	in	in	IN
cord-019001-ralxw4ad	423	10	the	the	DT
cord-019001-ralxw4ad	423	11	fetus	fetus	NN
cord-019001-ralxw4ad	423	12	and	and	CC
cord-019001-ralxw4ad	423	13	newborn	newborn	JJ
cord-019001-ralxw4ad	423	14	Effects	effect	NNS
cord-019001-ralxw4ad	423	15	of	of	IN
cord-019001-ralxw4ad	423	16	birth	birth	NN
cord-019001-ralxw4ad	423	17	-	-	HYPH
cord-019001-ralxw4ad	423	18	related	relate	VBN
cord-019001-ralxw4ad	423	19	stimuli	stimulus	NNS
cord-019001-ralxw4ad	423	20	on	on	IN
cord-019001-ralxw4ad	423	21	L	l	NN
cord-019001-ralxw4ad	423	22	-	-	HYPH
cord-019001-ralxw4ad	423	23	arginine	arginine	NN
cord-019001-ralxw4ad	423	24	-	-	HYPH
cord-019001-ralxw4ad	423	25	dependent	dependent	JJ
cord-019001-ralxw4ad	423	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	423	27	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	423	28	in	in	IN
cord-019001-ralxw4ad	423	29	ovine	ovine	JJ
cord-019001-ralxw4ad	423	30	fetus	fetus	NN
cord-019001-ralxw4ad	423	31	Ventilation	ventilation	NN
cord-019001-ralxw4ad	423	32	and	and	CC
cord-019001-ralxw4ad	423	33	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	424	1	induce	induce	VB
cord-019001-ralxw4ad	424	2	endothelial	endothelial	JJ
cord-019001-ralxw4ad	424	3	nitric	nitric	JJ
cord-019001-ralxw4ad	424	4	oxide	oxide	NN
cord-019001-ralxw4ad	424	5	synthase	synthase	NN
cord-019001-ralxw4ad	424	6	gene	gene	NN
cord-019001-ralxw4ad	424	7	expression	expression	NN
cord-019001-ralxw4ad	424	8	in	in	IN
cord-019001-ralxw4ad	424	9	the	the	DT
cord-019001-ralxw4ad	424	10	lungs	lung	NNS
cord-019001-ralxw4ad	424	11	of	of	IN
cord-019001-ralxw4ad	424	12	fetal	fetal	JJ
cord-019001-ralxw4ad	424	13	lambs	lamb	NNS
cord-019001-ralxw4ad	424	14	Chronic	Chronic	NNP
cord-019001-ralxw4ad	424	15	nitric	nitric	JJ
cord-019001-ralxw4ad	424	16	oxide	oxide	NN
cord-019001-ralxw4ad	424	17	inhibition	inhibition	NN
cord-019001-ralxw4ad	424	18	in	in	IN
cord-019001-ralxw4ad	424	19	utero	utero	NN
cord-019001-ralxw4ad	425	1	produces	produce	VBZ
cord-019001-ralxw4ad	425	2	persistent	persistent	JJ
cord-019001-ralxw4ad	425	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	425	4	hypertension	hypertension	NN
cord-019001-ralxw4ad	425	5	in	in	IN
cord-019001-ralxw4ad	425	6	newborn	newborn	JJ
cord-019001-ralxw4ad	425	7	lambs	lamb	NNS
cord-019001-ralxw4ad	425	8	Endothelin-1	Endothelin-1	NNP
cord-019001-ralxw4ad	425	9	in	in	IN
cord-019001-ralxw4ad	425	10	congenital	congenital	JJ
cord-019001-ralxw4ad	425	11	heart	heart	NN
cord-019001-ralxw4ad	425	12	disease	disease	NN
cord-019001-ralxw4ad	426	1	Increased	increase	VBN
cord-019001-ralxw4ad	426	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	426	3	blood	blood	NN
cord-019001-ralxw4ad	426	4	fl	fl	NNP
cord-019001-ralxw4ad	426	5	ow	ow	NNP
cord-019001-ralxw4ad	426	6	alters	alter	VBZ
cord-019001-ralxw4ad	426	7	the	the	DT
cord-019001-ralxw4ad	426	8	molecular	molecular	JJ
cord-019001-ralxw4ad	426	9	regulation	regulation	NN
cord-019001-ralxw4ad	426	10	of	of	IN
cord-019001-ralxw4ad	426	11	vascular	vascular	JJ
cord-019001-ralxw4ad	426	12	reactivity	reactivity	NN
cord-019001-ralxw4ad	426	13	in	in	IN
cord-019001-ralxw4ad	426	14	the	the	DT
cord-019001-ralxw4ad	426	15	lamb	lamb	NN
cord-019001-ralxw4ad	426	16	Altered	alter	VBD
cord-019001-ralxw4ad	426	17	regulation	regulation	NN
cord-019001-ralxw4ad	426	18	of	of	IN
cord-019001-ralxw4ad	426	19	the	the	DT
cord-019001-ralxw4ad	426	20	ET-1	ET-1	NNP
cord-019001-ralxw4ad	426	21	cascade	cascade	NN
cord-019001-ralxw4ad	426	22	in	in	IN
cord-019001-ralxw4ad	426	23	lambs	lamb	NNS
cord-019001-ralxw4ad	426	24	with	with	IN
cord-019001-ralxw4ad	426	25	increased	increase	VBN
cord-019001-ralxw4ad	426	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	426	27	blood	blood	NN
cord-019001-ralxw4ad	426	28	fl	fl	NNP
cord-019001-ralxw4ad	426	29	ow	ow	NN
cord-019001-ralxw4ad	426	30	and	and	CC
cord-019001-ralxw4ad	426	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	426	32	hypertension	hypertension	NN
cord-019001-ralxw4ad	426	33	Alterations	alteration	NNS
cord-019001-ralxw4ad	426	34	in	in	IN
cord-019001-ralxw4ad	426	35	nitric	nitric	JJ
cord-019001-ralxw4ad	426	36	oxide	oxide	NN
cord-019001-ralxw4ad	426	37	production	production	NN
cord-019001-ralxw4ad	426	38	in	in	IN
cord-019001-ralxw4ad	426	39	8-week	8-week	JJ
cord-019001-ralxw4ad	426	40	-	-	HYPH
cord-019001-ralxw4ad	426	41	old	old	JJ
cord-019001-ralxw4ad	426	42	lambs	lamb	NNS
cord-019001-ralxw4ad	426	43	with	with	IN
cord-019001-ralxw4ad	426	44	increased	increase	VBN
cord-019001-ralxw4ad	426	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	426	46	blood	blood	NN
cord-019001-ralxw4ad	426	47	fl	fl	NNP
cord-019001-ralxw4ad	427	1	ow	ow	UH
cord-019001-ralxw4ad	427	2	Increased	increase	VBD
cord-019001-ralxw4ad	427	3	endothelial	endothelial	JJ
cord-019001-ralxw4ad	427	4	NOS	NOS	NNP
cord-019001-ralxw4ad	427	5	in	in	IN
cord-019001-ralxw4ad	427	6	lambs	lamb	NNS
cord-019001-ralxw4ad	427	7	with	with	IN
cord-019001-ralxw4ad	427	8	increased	increase	VBN
cord-019001-ralxw4ad	427	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	427	10	blood	blood	NN
cord-019001-ralxw4ad	427	11	fl	fl	NNP
cord-019001-ralxw4ad	427	12	ow	ow	NN
cord-019001-ralxw4ad	427	13	and	and	CC
cord-019001-ralxw4ad	427	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	427	15	hypertension	hypertension	NN
cord-019001-ralxw4ad	427	16	Emergence	emergence	NN
cord-019001-ralxw4ad	427	17	of	of	IN
cord-019001-ralxw4ad	427	18	smooth	smooth	JJ
cord-019001-ralxw4ad	427	19	muscle	muscle	NN
cord-019001-ralxw4ad	427	20	cell	cell	NN
cord-019001-ralxw4ad	427	21	endothelin	endothelin	NN
cord-019001-ralxw4ad	427	22	Bmediated	Bmediated	NNP
cord-019001-ralxw4ad	427	23	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	427	24	in	in	IN
cord-019001-ralxw4ad	427	25	lambs	lamb	NNS
cord-019001-ralxw4ad	427	26	with	with	IN
cord-019001-ralxw4ad	427	27	experimental	experimental	JJ
cord-019001-ralxw4ad	427	28	congenital	congenital	JJ
cord-019001-ralxw4ad	427	29	heart	heart	NN
cord-019001-ralxw4ad	427	30	disease	disease	NN
cord-019001-ralxw4ad	427	31	and	and	CC
cord-019001-ralxw4ad	427	32	increased	increase	VBN
cord-019001-ralxw4ad	427	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	427	34	blood	blood	NN
cord-019001-ralxw4ad	427	35	fl	fl	NNP
cord-019001-ralxw4ad	428	1	ow	ow	UH
cord-019001-ralxw4ad	428	2	sGC	sGC	NNP
cord-019001-ralxw4ad	428	3	and	and	CC
cord-019001-ralxw4ad	428	4	PDE5	PDE5	NNP
cord-019001-ralxw4ad	428	5	are	be	VBP
cord-019001-ralxw4ad	428	6	elevated	elevate	VBN
cord-019001-ralxw4ad	428	7	in	in	IN
cord-019001-ralxw4ad	428	8	lambs	lamb	NNS
cord-019001-ralxw4ad	428	9	with	with	IN
cord-019001-ralxw4ad	428	10	increased	increase	VBN
cord-019001-ralxw4ad	428	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	428	12	blood	blood	NN
cord-019001-ralxw4ad	428	13	fl	fl	NNP
cord-019001-ralxw4ad	428	14	ow	ow	NN
cord-019001-ralxw4ad	428	15	and	and	CC
cord-019001-ralxw4ad	428	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	428	17	hypertension	hypertension	NN
cord-019001-ralxw4ad	428	18	Altered	alter	VBD
cord-019001-ralxw4ad	428	19	endothelial	endothelial	JJ
cord-019001-ralxw4ad	428	20	function	function	NN
cord-019001-ralxw4ad	428	21	in	in	IN
cord-019001-ralxw4ad	428	22	lambs	lamb	NNS
cord-019001-ralxw4ad	428	23	with	with	IN
cord-019001-ralxw4ad	428	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	428	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	428	26	and	and	CC
cord-019001-ralxw4ad	428	27	acute	acute	JJ
cord-019001-ralxw4ad	428	28	lung	lung	NN
cord-019001-ralxw4ad	428	29	injury	injury	NN
cord-019001-ralxw4ad	428	30	Alterations	alteration	NNS
cord-019001-ralxw4ad	428	31	in	in	IN
cord-019001-ralxw4ad	428	32	TGF	TGF	NNP
cord-019001-ralxw4ad	428	33	-	-	HYPH
cord-019001-ralxw4ad	428	34	beta1	beta1	VBG
cord-019001-ralxw4ad	428	35	expression	expression	NN
cord-019001-ralxw4ad	428	36	in	in	IN
cord-019001-ralxw4ad	428	37	lambs	lamb	NNS
cord-019001-ralxw4ad	428	38	with	with	IN
cord-019001-ralxw4ad	428	39	increased	increase	VBN
cord-019001-ralxw4ad	428	40	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	428	41	blood	blood	NN
cord-019001-ralxw4ad	428	42	fl	fl	NNP
cord-019001-ralxw4ad	428	43	ow	ow	NN
cord-019001-ralxw4ad	428	44	and	and	CC
cord-019001-ralxw4ad	428	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	428	46	hypertension	hypertension	NN
cord-019001-ralxw4ad	428	47	Alterations	alteration	NNS
cord-019001-ralxw4ad	428	48	in	in	IN
cord-019001-ralxw4ad	428	49	ET-1	ET-1	NNP
cord-019001-ralxw4ad	428	50	,	,	,
cord-019001-ralxw4ad	428	51	not	not	RB
cord-019001-ralxw4ad	428	52	nitric	nitric	JJ
cord-019001-ralxw4ad	428	53	oxide	oxide	NN
cord-019001-ralxw4ad	428	54	,	,	,
cord-019001-ralxw4ad	428	55	in	in	IN
cord-019001-ralxw4ad	428	56	1-week	1-week	CD
cord-019001-ralxw4ad	428	57	-	-	JJ
cord-019001-ralxw4ad	428	58	old	old	JJ
cord-019001-ralxw4ad	428	59	lambs	lamb	NNS
cord-019001-ralxw4ad	428	60	with	with	IN
cord-019001-ralxw4ad	428	61	increased	increase	VBN
cord-019001-ralxw4ad	428	62	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	428	63	blood	blood	NN
cord-019001-ralxw4ad	428	64	fl	fl	NNP
cord-019001-ralxw4ad	428	65	ow	ow	NNP
cord-019001-ralxw4ad	429	1	In	in	IN
cord-019001-ralxw4ad	429	2	utero	utero	NN
cord-019001-ralxw4ad	429	3	placement	placement	NN
cord-019001-ralxw4ad	429	4	of	of	IN
cord-019001-ralxw4ad	429	5	aortopulmonary	aortopulmonary	JJ
cord-019001-ralxw4ad	429	6	shunts	shunt	NNS
cord-019001-ralxw4ad	429	7	.	.	.
cord-019001-ralxw4ad	430	1	A	a	DT
cord-019001-ralxw4ad	430	2	model	model	NN
cord-019001-ralxw4ad	430	3	of	of	IN
cord-019001-ralxw4ad	430	4	postnatal	postnatal	JJ
cord-019001-ralxw4ad	430	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	430	6	hypertension	hypertension	NN
cord-019001-ralxw4ad	430	7	with	with	IN
cord-019001-ralxw4ad	430	8	increased	increase	VBN
cord-019001-ralxw4ad	430	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	430	10	blood	blood	NN
cord-019001-ralxw4ad	430	11	fl	fl	NNP
cord-019001-ralxw4ad	430	12	ow	ow	NN
cord-019001-ralxw4ad	430	13	in	in	IN
cord-019001-ralxw4ad	430	14	lambs	lamb	NNS
cord-019001-ralxw4ad	431	1	The	the	DT
cord-019001-ralxw4ad	431	2	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	431	3	of	of	IN
cord-019001-ralxw4ad	431	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	431	5	hypertension	hypertension	NN
cord-019001-ralxw4ad	431	6	in	in	IN
cord-019001-ralxw4ad	431	7	congenital	congenital	JJ
cord-019001-ralxw4ad	431	8	heart	heart	NN
cord-019001-ralxw4ad	431	9	disease	disease	NN
cord-019001-ralxw4ad	431	10	Altered	alter	VBD
cord-019001-ralxw4ad	431	11	endothelium	endothelium	NN
cord-019001-ralxw4ad	431	12	-	-	HYPH
cord-019001-ralxw4ad	431	13	dependent	dependent	JJ
cord-019001-ralxw4ad	431	14	relaxations	relaxation	NNS
cord-019001-ralxw4ad	431	15	in	in	IN
cord-019001-ralxw4ad	431	16	lambs	lamb	NNS
cord-019001-ralxw4ad	431	17	with	with	IN
cord-019001-ralxw4ad	431	18	high	high	JJ
cord-019001-ralxw4ad	431	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	431	20	blood	blood	NN
cord-019001-ralxw4ad	431	21	fl	fl	NNP
cord-019001-ralxw4ad	431	22	ow	ow	NN
cord-019001-ralxw4ad	431	23	and	and	CC
cord-019001-ralxw4ad	432	1	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	432	2	hypertension	hypertension	NN
cord-019001-ralxw4ad	432	3	Endothelin-1	Endothelin-1	NNP
cord-019001-ralxw4ad	432	4	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	432	5	responses	response	NNS
cord-019001-ralxw4ad	432	6	in	in	IN
cord-019001-ralxw4ad	432	7	lambs	lamb	NNS
cord-019001-ralxw4ad	432	8	with	with	IN
cord-019001-ralxw4ad	432	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	432	10	hypertension	hypertension	NN
cord-019001-ralxw4ad	432	11	and	and	CC
cord-019001-ralxw4ad	432	12	increased	increase	VBN
cord-019001-ralxw4ad	432	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	432	14	blood	blood	NN
cord-019001-ralxw4ad	433	1	fl	fl	NNP
cord-019001-ralxw4ad	434	1	ow	ow	UH
cord-019001-ralxw4ad	434	2	Failure	failure	NN
cord-019001-ralxw4ad	434	3	of	of	IN
cord-019001-ralxw4ad	434	4	postnatal	postnatal	JJ
cord-019001-ralxw4ad	434	5	adaptation	adaptation	NN
cord-019001-ralxw4ad	434	6	of	of	IN
cord-019001-ralxw4ad	434	7	the	the	DT
cord-019001-ralxw4ad	434	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	434	9	circulation	circulation	NN
cord-019001-ralxw4ad	434	10	after	after	IN
cord-019001-ralxw4ad	434	11	chronic	chronic	JJ
cord-019001-ralxw4ad	434	12	intrauterine	intrauterine	JJ
cord-019001-ralxw4ad	434	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	434	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	434	15	in	in	IN
cord-019001-ralxw4ad	434	16	fetal	fetal	JJ
cord-019001-ralxw4ad	434	17	lambs	lamb	NNS
cord-019001-ralxw4ad	434	18	Persistent	persistent	JJ
cord-019001-ralxw4ad	434	19	fetal	fetal	JJ
cord-019001-ralxw4ad	434	20	circulation	circulation	NN
cord-019001-ralxw4ad	434	21	:	:	:
cord-019001-ralxw4ad	434	22	newly	newly	RB
cord-019001-ralxw4ad	434	23	recognized	recognize	VBN
cord-019001-ralxw4ad	434	24	structural	structural	JJ
cord-019001-ralxw4ad	434	25	features	feature	NNS
cord-019001-ralxw4ad	435	1	The	the	DT
cord-019001-ralxw4ad	435	2	structural	structural	JJ
cord-019001-ralxw4ad	435	3	basis	basis	NN
cord-019001-ralxw4ad	435	4	of	of	IN
cord-019001-ralxw4ad	435	5	persistent	persistent	JJ
cord-019001-ralxw4ad	435	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	435	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	435	8	of	of	IN
cord-019001-ralxw4ad	435	9	the	the	DT
cord-019001-ralxw4ad	435	10	newborn	newborn	JJ
cord-019001-ralxw4ad	435	11	infant	infant	NN
cord-019001-ralxw4ad	435	12	Pharmacologic	Pharmacologic	NNP
cord-019001-ralxw4ad	435	13	therapy	therapy	NN
cord-019001-ralxw4ad	435	14	for	for	IN
cord-019001-ralxw4ad	435	15	persistent	persistent	JJ
cord-019001-ralxw4ad	435	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	435	17	hypertension	hypertension	NN
cord-019001-ralxw4ad	435	18	of	of	IN
cord-019001-ralxw4ad	435	19	the	the	DT
cord-019001-ralxw4ad	435	20	newborn	newborn	NN
cord-019001-ralxw4ad	435	21	:	:	:
cord-019001-ralxw4ad	435	22	as	as	IN
cord-019001-ralxw4ad	435	23	"	"	``
cord-019001-ralxw4ad	435	24	poly	poly	JJ
cord-019001-ralxw4ad	435	25	"	"	''
cord-019001-ralxw4ad	435	26	as	as	IN
cord-019001-ralxw4ad	435	27	the	the	DT
cord-019001-ralxw4ad	435	28	disease	disease	NN
cord-019001-ralxw4ad	435	29	itself	-PRON-	PRP
cord-019001-ralxw4ad	435	30	Structure	Structure	NNP
cord-019001-ralxw4ad	435	31	and	and	CC
cord-019001-ralxw4ad	435	32	function	function	VB
cord-019001-ralxw4ad	435	33	in	in	IN
cord-019001-ralxw4ad	435	34	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	435	35	hypertension	hypertension	NN
cord-019001-ralxw4ad	435	36	.	.	.
cord-019001-ralxw4ad	436	1	New	new	JJ
cord-019001-ralxw4ad	436	2	perceptions	perception	NNS
cord-019001-ralxw4ad	436	3	Elevated	elevate	VBN
cord-019001-ralxw4ad	436	4	immunoreactive	immunoreactive	JJ
cord-019001-ralxw4ad	436	5	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	436	6	levels	level	NNS
cord-019001-ralxw4ad	436	7	in	in	IN
cord-019001-ralxw4ad	436	8	newborn	newborn	JJ
cord-019001-ralxw4ad	436	9	infants	infant	NNS
cord-019001-ralxw4ad	436	10	with	with	IN
cord-019001-ralxw4ad	436	11	persistent	persistent	JJ
cord-019001-ralxw4ad	436	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	436	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	436	14	Loss	loss	NN
cord-019001-ralxw4ad	436	15	of	of	IN
cord-019001-ralxw4ad	436	16	endothelium	endothelium	NN
cord-019001-ralxw4ad	436	17	-	-	HYPH
cord-019001-ralxw4ad	436	18	dependent	dependent	JJ
cord-019001-ralxw4ad	436	19	relaxant	relaxant	NN
cord-019001-ralxw4ad	436	20	activity	activity	NN
cord-019001-ralxw4ad	436	21	in	in	IN
cord-019001-ralxw4ad	436	22	the	the	DT
cord-019001-ralxw4ad	436	23	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	436	24	circulation	circulation	NN
cord-019001-ralxw4ad	436	25	of	of	IN
cord-019001-ralxw4ad	436	26	rats	rat	NNS
cord-019001-ralxw4ad	436	27	exposed	expose	VBN
cord-019001-ralxw4ad	436	28	to	to	IN
cord-019001-ralxw4ad	436	29	chronic	chronic	JJ
cord-019001-ralxw4ad	436	30	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	437	1	An	an	DT
cord-019001-ralxw4ad	437	2	imbalance	imbalance	NN
cord-019001-ralxw4ad	437	3	between	between	IN
cord-019001-ralxw4ad	437	4	the	the	DT
cord-019001-ralxw4ad	437	5	excretion	excretion	NN
cord-019001-ralxw4ad	437	6	of	of	IN
cord-019001-ralxw4ad	437	7	thromboxane	thromboxane	NN
cord-019001-ralxw4ad	437	8	and	and	CC
cord-019001-ralxw4ad	437	9	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	437	10	metabolites	metabolite	NNS
cord-019001-ralxw4ad	437	11	in	in	IN
cord-019001-ralxw4ad	437	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	437	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	438	1	Pulmonary	Pulmonary	NNP
cord-019001-ralxw4ad	438	2	PKG-1	PKG-1	NNP
cord-019001-ralxw4ad	438	3	is	be	VBZ
cord-019001-ralxw4ad	438	4	upregulated	upregulate	VBN
cord-019001-ralxw4ad	438	5	following	follow	VBG
cord-019001-ralxw4ad	438	6	chronic	chronic	JJ
cord-019001-ralxw4ad	438	7	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	438	8	Models	model	NNS
cord-019001-ralxw4ad	438	9	of	of	IN
cord-019001-ralxw4ad	438	10	persistent	persistent	JJ
cord-019001-ralxw4ad	438	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	438	13	of	of	IN
cord-019001-ralxw4ad	438	14	the	the	DT
cord-019001-ralxw4ad	438	15	newborn	newborn	NN
cord-019001-ralxw4ad	438	16	(	(	-LRB-
cord-019001-ralxw4ad	438	17	PPHN	PPHN	NNP
cord-019001-ralxw4ad	438	18	)	)	-RRB-
cord-019001-ralxw4ad	438	19	and	and	CC
cord-019001-ralxw4ad	438	20	the	the	DT
cord-019001-ralxw4ad	438	21	role	role	NN
cord-019001-ralxw4ad	438	22	of	of	IN
cord-019001-ralxw4ad	438	23	cyclic	cyclic	JJ
cord-019001-ralxw4ad	438	24	guanosine	guanosine	NN
cord-019001-ralxw4ad	438	25	monophosphate	monophosphate	NN
cord-019001-ralxw4ad	438	26	(	(	-LRB-
cord-019001-ralxw4ad	438	27	GMP	GMP	NNP
cord-019001-ralxw4ad	438	28	)	)	-RRB-
cord-019001-ralxw4ad	438	29	in	in	IN
cord-019001-ralxw4ad	438	30	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	31	vasorelaxation	vasorelaxation	NN
cord-019001-ralxw4ad	438	32	Physical	physical	JJ
cord-019001-ralxw4ad	438	33	factors	factor	NNS
cord-019001-ralxw4ad	438	34	affecting	affect	VBG
cord-019001-ralxw4ad	438	35	normal	normal	JJ
cord-019001-ralxw4ad	438	36	and	and	CC
cord-019001-ralxw4ad	438	37	serotonin	serotonin	NN
cord-019001-ralxw4ad	438	38	-	-	HYPH
cord-019001-ralxw4ad	438	39	constricted	constrict	VBN
cord-019001-ralxw4ad	438	40	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	41	vessels	vessel	NNS
cord-019001-ralxw4ad	438	42	Response	response	NN
cord-019001-ralxw4ad	438	43	of	of	IN
cord-019001-ralxw4ad	438	44	the	the	DT
cord-019001-ralxw4ad	438	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	46	vasculature	vasculature	NN
cord-019001-ralxw4ad	438	47	to	to	IN
cord-019001-ralxw4ad	438	48	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	438	49	and	and	CC
cord-019001-ralxw4ad	438	50	H+	H+	NNP
cord-019001-ralxw4ad	438	51	ion	ion	NN
cord-019001-ralxw4ad	438	52	concentration	concentration	NN
cord-019001-ralxw4ad	438	53	changes	change	VBZ
cord-019001-ralxw4ad	438	54	Site	site	NN
cord-019001-ralxw4ad	438	55	and	and	CC
cord-019001-ralxw4ad	438	56	sensitivity	sensitivity	NN
cord-019001-ralxw4ad	438	57	for	for	IN
cord-019001-ralxw4ad	438	58	stimulation	stimulation	NN
cord-019001-ralxw4ad	438	59	of	of	IN
cord-019001-ralxw4ad	438	60	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	438	61	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	62	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	438	63	Infl	Infl	NNP
cord-019001-ralxw4ad	438	64	uence	uence	NN
cord-019001-ralxw4ad	438	65	of	of	IN
cord-019001-ralxw4ad	438	66	alveolar	alveolar	JJ
cord-019001-ralxw4ad	438	67	oxygen	oxygen	NN
cord-019001-ralxw4ad	438	68	on	on	IN
cord-019001-ralxw4ad	438	69	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	70	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	438	71	in	in	IN
cord-019001-ralxw4ad	438	72	newborn	newborn	JJ
cord-019001-ralxw4ad	438	73	lambs	lamb	NNS
cord-019001-ralxw4ad	438	74	versus	versus	IN
cord-019001-ralxw4ad	438	75	sheep	sheep	NN
cord-019001-ralxw4ad	438	76	Hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	438	77	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	438	78	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	438	79	.	.	.
cord-019001-ralxw4ad	439	1	Physiologic	physiologic	JJ
cord-019001-ralxw4ad	439	2	signifi	signifi	NN
cord-019001-ralxw4ad	439	3	cance	cance	NN
cord-019001-ralxw4ad	439	4	,	,	,
cord-019001-ralxw4ad	439	5	mechanism	mechanism	NN
cord-019001-ralxw4ad	439	6	,	,	,
cord-019001-ralxw4ad	439	7	and	and	CC
cord-019001-ralxw4ad	439	8	clinical	clinical	JJ
cord-019001-ralxw4ad	439	9	relevance	relevance	NN
cord-019001-ralxw4ad	440	1	Hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	440	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	440	3	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	440	4	Increased	increase	VBD
cord-019001-ralxw4ad	440	5	arterial	arterial	JJ
cord-019001-ralxw4ad	440	6	pH	ph	NN
cord-019001-ralxw4ad	440	7	,	,	,
cord-019001-ralxw4ad	440	8	not	not	RB
cord-019001-ralxw4ad	440	9	decreased	decrease	VBD
cord-019001-ralxw4ad	440	10	PaCO	paco	NN
cord-019001-ralxw4ad	440	11	2	2	CD
cord-019001-ralxw4ad	440	12	,	,	,
cord-019001-ralxw4ad	440	13	attenuates	attenuate	VBZ
cord-019001-ralxw4ad	440	14	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	440	15	-	-	HYPH
cord-019001-ralxw4ad	440	16	induced	induce	VBN
cord-019001-ralxw4ad	440	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	440	18	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	440	19	in	in	IN
cord-019001-ralxw4ad	440	20	newborn	newborn	JJ
cord-019001-ralxw4ad	440	21	lambs	lamb	NNS
cord-019001-ralxw4ad	441	1	The	the	DT
cord-019001-ralxw4ad	441	2	effect	effect	NN
cord-019001-ralxw4ad	441	3	of	of	IN
cord-019001-ralxw4ad	441	4	hypocarbia	hypocarbia	NN
cord-019001-ralxw4ad	441	5	on	on	IN
cord-019001-ralxw4ad	441	6	the	the	DT
cord-019001-ralxw4ad	441	7	cardiovascular	cardiovascular	JJ
cord-019001-ralxw4ad	441	8	system	system	NN
cord-019001-ralxw4ad	441	9	of	of	IN
cord-019001-ralxw4ad	441	10	puppies	puppy	NNS
cord-019001-ralxw4ad	441	11	Pulmonary	Pulmonary	NNP
cord-019001-ralxw4ad	441	12	vascular	vascular	JJ
cord-019001-ralxw4ad	441	13	K+	k+	JJ
cord-019001-ralxw4ad	441	14	channel	channel	NN
cord-019001-ralxw4ad	441	15	expression	expression	NN
cord-019001-ralxw4ad	441	16	and	and	CC
cord-019001-ralxw4ad	441	17	vasoreactivity	vasoreactivity	NN
cord-019001-ralxw4ad	441	18	in	in	IN
cord-019001-ralxw4ad	441	19	a	a	DT
cord-019001-ralxw4ad	441	20	model	model	NN
cord-019001-ralxw4ad	441	21	of	of	IN
cord-019001-ralxw4ad	441	22	congenital	congenital	JJ
cord-019001-ralxw4ad	441	23	heart	heart	NN
cord-019001-ralxw4ad	441	24	disease	disease	NN
cord-019001-ralxw4ad	442	1	The	the	DT
cord-019001-ralxw4ad	442	2	nervous	nervous	JJ
cord-019001-ralxw4ad	442	3	control	control	NN
cord-019001-ralxw4ad	442	4	of	of	IN
cord-019001-ralxw4ad	442	5	the	the	DT
cord-019001-ralxw4ad	442	6	circulation	circulation	NN
cord-019001-ralxw4ad	442	7	in	in	IN
cord-019001-ralxw4ad	442	8	the	the	DT
cord-019001-ralxw4ad	442	9	foetal	foetal	NN
cord-019001-ralxw4ad	442	10	and	and	CC
cord-019001-ralxw4ad	442	11	newly	newly	RB
cord-019001-ralxw4ad	442	12	expanded	expand	VBN
cord-019001-ralxw4ad	442	13	lungs	lung	NNS
cord-019001-ralxw4ad	442	14	of	of	IN
cord-019001-ralxw4ad	442	15	the	the	DT
cord-019001-ralxw4ad	442	16	lamb	lamb	NNP
cord-019001-ralxw4ad	442	17	Physiology	Physiology	NNP
cord-019001-ralxw4ad	442	18	and	and	CC
cord-019001-ralxw4ad	442	19	pharmacology	pharmacology	NN
cord-019001-ralxw4ad	442	20	of	of	IN
cord-019001-ralxw4ad	442	21	the	the	DT
cord-019001-ralxw4ad	442	22	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	442	23	circulation	circulation	NN
cord-019001-ralxw4ad	442	24	in	in	IN
cord-019001-ralxw4ad	442	25	the	the	DT
cord-019001-ralxw4ad	442	26	fetus	fetus	NN
cord-019001-ralxw4ad	442	27	and	and	CC
cord-019001-ralxw4ad	442	28	newborn	newborn	JJ
cord-019001-ralxw4ad	442	29	Poiseuille	Poiseuille	NNP
cord-019001-ralxw4ad	442	30	's	's	POS
cord-019001-ralxw4ad	442	31	law	law	NN
cord-019001-ralxw4ad	442	32	and	and	CC
cord-019001-ralxw4ad	442	33	its	-PRON-	PRP$
cord-019001-ralxw4ad	442	34	limitations	limitation	NNS
cord-019001-ralxw4ad	442	35	in	in	IN
cord-019001-ralxw4ad	442	36	vascular	vascular	JJ
cord-019001-ralxw4ad	442	37	systems	system	NNS
cord-019001-ralxw4ad	442	38	Mechanics	mechanic	NNS
cord-019001-ralxw4ad	442	39	of	of	IN
cord-019001-ralxw4ad	442	40	the	the	DT
cord-019001-ralxw4ad	442	41	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	442	42	circulation	circulation	NN
cord-019001-ralxw4ad	442	43	Applied	Applied	NNP
cord-019001-ralxw4ad	442	44	Hydro	Hydro	NNP
cord-019001-ralxw4ad	442	45	-	-	HYPH
cord-019001-ralxw4ad	442	46	and	and	CC
cord-019001-ralxw4ad	442	47	Aeromechanics	Aeromechanics	NNP
cord-019001-ralxw4ad	442	48	Congenital	Congenital	NNP
cord-019001-ralxw4ad	442	49	Diseases	Diseases	NNPS
cord-019001-ralxw4ad	442	50	of	of	IN
cord-019001-ralxw4ad	442	51	the	the	DT
cord-019001-ralxw4ad	442	52	Heart	heart	NN
cord-019001-ralxw4ad	442	53	:	:	:
cord-019001-ralxw4ad	442	54	Clinical	clinical	JJ
cord-019001-ralxw4ad	442	55	-	-	HYPH
cord-019001-ralxw4ad	442	56	Physiological	physiological	JJ
cord-019001-ralxw4ad	442	57	Considerations	consideration	NNS
cord-019001-ralxw4ad	442	58	Relative	relative	JJ
cord-019001-ralxw4ad	442	59	viscosity	viscosity	NN
cord-019001-ralxw4ad	442	60	of	of	IN
cord-019001-ralxw4ad	442	61	blood	blood	NN
cord-019001-ralxw4ad	442	62	at	at	IN
cord-019001-ralxw4ad	442	63	varying	vary	VBG
cord-019001-ralxw4ad	442	64	hematocrits	hematocrit	NNS
cord-019001-ralxw4ad	442	65	in	in	IN
cord-019001-ralxw4ad	442	66	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	442	67	circulation	circulation	NN
cord-019001-ralxw4ad	442	68	Effect	effect	NN
cord-019001-ralxw4ad	442	69	of	of	IN
cord-019001-ralxw4ad	442	70	hematocrit	hematocrit	NN
cord-019001-ralxw4ad	442	71	and	and	CC
cord-019001-ralxw4ad	442	72	inertial	inertial	JJ
cord-019001-ralxw4ad	442	73	losses	loss	NNS
cord-019001-ralxw4ad	442	74	on	on	IN
cord-019001-ralxw4ad	443	1	pressure	pressure	NN
cord-019001-ralxw4ad	443	2	-	-	HYPH
cord-019001-ralxw4ad	443	3	fl	fl	NNP
cord-019001-ralxw4ad	443	4	ow	ow	NNP
cord-019001-ralxw4ad	443	5	relations	relation	NNS
cord-019001-ralxw4ad	443	6	in	in	IN
cord-019001-ralxw4ad	443	7	the	the	DT
cord-019001-ralxw4ad	443	8	isolated	isolate	VBN
cord-019001-ralxw4ad	443	9	hindpaw	hindpaw	NN
cord-019001-ralxw4ad	444	1	o	o	UH
cord-019001-ralxw4ad	445	1	the	the	DT
cord-019001-ralxw4ad	445	2	dog	dog	NN
cord-019001-ralxw4ad	445	3	Mechanical	mechanical	JJ
cord-019001-ralxw4ad	445	4	infl	infl	NN
cord-019001-ralxw4ad	445	5	uences	uence	NNS
cord-019001-ralxw4ad	445	6	on	on	IN
cord-019001-ralxw4ad	445	7	the	the	DT
cord-019001-ralxw4ad	445	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	445	9	microcirculation	microcirculation	NN
cord-019001-ralxw4ad	445	10	Recruitment	Recruitment	NNP
cord-019001-ralxw4ad	445	11	vs.	vs.	CC
cord-019001-ralxw4ad	445	12	distensibility	distensibility	NN
cord-019001-ralxw4ad	445	13	in	in	IN
cord-019001-ralxw4ad	445	14	the	the	DT
cord-019001-ralxw4ad	445	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	445	16	vascular	vascular	JJ
cord-019001-ralxw4ad	445	17	bed	bed	NN
cord-019001-ralxw4ad	445	18	Relationship	relationship	NN
cord-019001-ralxw4ad	445	19	between	between	IN
cord-019001-ralxw4ad	445	20	regional	regional	JJ
cord-019001-ralxw4ad	445	21	lung	lung	NN
cord-019001-ralxw4ad	445	22	volume	volume	NN
cord-019001-ralxw4ad	445	23	and	and	CC
cord-019001-ralxw4ad	445	24	regional	regional	JJ
cord-019001-ralxw4ad	445	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	445	26	vascular	vascular	JJ
cord-019001-ralxw4ad	445	27	resistance	resistance	NN
cord-019001-ralxw4ad	446	1	Infl	Infl	NNP
cord-019001-ralxw4ad	446	2	uence	uence	NN
cord-019001-ralxw4ad	446	3	of	of	IN
cord-019001-ralxw4ad	446	4	state	state	NN
cord-019001-ralxw4ad	446	5	of	of	IN
cord-019001-ralxw4ad	446	6	infl	infl	NN
cord-019001-ralxw4ad	446	7	ation	ation	NN
cord-019001-ralxw4ad	446	8	of	of	IN
cord-019001-ralxw4ad	446	9	the	the	DT
cord-019001-ralxw4ad	446	10	lung	lung	NN
cord-019001-ralxw4ad	446	11	on	on	IN
cord-019001-ralxw4ad	446	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	446	13	vascular	vascular	JJ
cord-019001-ralxw4ad	446	14	resistance	resistance	NN
cord-019001-ralxw4ad	446	15	Biosynthesis	Biosynthesis	NNP
cord-019001-ralxw4ad	446	16	of	of	IN
cord-019001-ralxw4ad	446	17	nitric	nitric	NN
cord-019001-ralxw4ad	446	18	oxide	oxide	NN
cord-019001-ralxw4ad	446	19	and	and	CC
cord-019001-ralxw4ad	446	20	citrulline	citrulline	NN
cord-019001-ralxw4ad	446	21	from	from	IN
cord-019001-ralxw4ad	446	22	L	l	NN
cord-019001-ralxw4ad	446	23	-	-	HYPH
cord-019001-ralxw4ad	446	24	arginine	arginine	NN
cord-019001-ralxw4ad	446	25	by	by	IN
cord-019001-ralxw4ad	446	26	constitutive	constitutive	JJ
cord-019001-ralxw4ad	446	27	nitric	nitric	NN
cord-019001-ralxw4ad	446	28	oxide	oxide	NN
cord-019001-ralxw4ad	446	29	synthase	synthase	NN
cord-019001-ralxw4ad	446	30	present	present	NN
cord-019001-ralxw4ad	446	31	in	in	IN
cord-019001-ralxw4ad	446	32	rabbit	rabbit	NN
cord-019001-ralxw4ad	446	33	corpus	corpus	NNP
cord-019001-ralxw4ad	446	34	cavernosum	cavernosum	NNP
cord-019001-ralxw4ad	446	35	Endothelium	Endothelium	NNP
cord-019001-ralxw4ad	446	36	-	-	HYPH
cord-019001-ralxw4ad	446	37	derived	derive	VBN
cord-019001-ralxw4ad	446	38	relaxing	relaxing	JJ
cord-019001-ralxw4ad	446	39	factor	factor	NN
cord-019001-ralxw4ad	446	40	from	from	IN
cord-019001-ralxw4ad	446	41	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	446	42	artery	artery	NN
cord-019001-ralxw4ad	446	43	and	and	CC
cord-019001-ralxw4ad	446	44	vein	vein	NN
cord-019001-ralxw4ad	446	45	possesses	possess	VBZ
cord-019001-ralxw4ad	446	46	pharmacologic	pharmacologic	JJ
cord-019001-ralxw4ad	446	47	and	and	CC
cord-019001-ralxw4ad	446	48	chemical	chemical	JJ
cord-019001-ralxw4ad	446	49	properties	property	NNS
cord-019001-ralxw4ad	446	50	identical	identical	JJ
cord-019001-ralxw4ad	446	51	to	to	IN
cord-019001-ralxw4ad	446	52	those	those	DT
cord-019001-ralxw4ad	446	53	of	of	IN
cord-019001-ralxw4ad	446	54	nitric	nitric	NN
cord-019001-ralxw4ad	446	55	oxide	oxide	NN
cord-019001-ralxw4ad	446	56	radical	radical	JJ
cord-019001-ralxw4ad	446	57	Pharmacology	Pharmacology	NNP
cord-019001-ralxw4ad	446	58	of	of	IN
cord-019001-ralxw4ad	446	59	endotheliumderived	endotheliumderived	NNP
cord-019001-ralxw4ad	446	60	nitric	nitric	NN
cord-019001-ralxw4ad	446	61	oxide	oxide	NN
cord-019001-ralxw4ad	446	62	and	and	CC
cord-019001-ralxw4ad	446	63	nitrovasodilators	nitrovasodilators	NNP
cord-019001-ralxw4ad	446	64	Activation	Activation	NNP
cord-019001-ralxw4ad	446	65	of	of	IN
cord-019001-ralxw4ad	446	66	purifi	purifi	NNP
cord-019001-ralxw4ad	446	67	ed	ed	NNP
cord-019001-ralxw4ad	446	68	soluble	soluble	JJ
cord-019001-ralxw4ad	446	69	guanylate	guanylate	NN
cord-019001-ralxw4ad	446	70	cyclase	cyclase	NN
cord-019001-ralxw4ad	446	71	by	by	IN
cord-019001-ralxw4ad	446	72	endothelium	endothelium	NN
cord-019001-ralxw4ad	446	73	-	-	HYPH
cord-019001-ralxw4ad	446	74	derived	derive	VBN
cord-019001-ralxw4ad	446	75	relaxing	relaxing	JJ
cord-019001-ralxw4ad	446	76	factor	factor	NN
cord-019001-ralxw4ad	446	77	from	from	IN
cord-019001-ralxw4ad	446	78	intrapulmonary	intrapulmonary	JJ
cord-019001-ralxw4ad	446	79	artery	artery	NN
cord-019001-ralxw4ad	446	80	and	and	CC
cord-019001-ralxw4ad	446	81	vein	vein	NN
cord-019001-ralxw4ad	446	82	:	:	:
cord-019001-ralxw4ad	446	83	stimulation	stimulation	NN
cord-019001-ralxw4ad	446	84	by	by	IN
cord-019001-ralxw4ad	446	85	acetylcholine	acetylcholine	NN
cord-019001-ralxw4ad	446	86	,	,	,
cord-019001-ralxw4ad	446	87	bradykinin	bradykinin	NN
cord-019001-ralxw4ad	446	88	and	and	CC
cord-019001-ralxw4ad	446	89	arachidonic	arachidonic	NN
cord-019001-ralxw4ad	446	90	acid	acid	NN
cord-019001-ralxw4ad	446	91	Cyclic	cyclic	JJ
cord-019001-ralxw4ad	446	92	guanosine	guanosine	NN
cord-019001-ralxw4ad	446	93	monophosphate	monophosphate	NN
cord-019001-ralxw4ad	446	94	as	as	IN
cord-019001-ralxw4ad	446	95	a	a	DT
cord-019001-ralxw4ad	446	96	mediator	mediator	NN
cord-019001-ralxw4ad	446	97	of	of	IN
cord-019001-ralxw4ad	446	98	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	446	99	Nitric	nitric	NN
cord-019001-ralxw4ad	446	100	oxide	oxide	NN
cord-019001-ralxw4ad	446	101	synthesis	synthesis	NN
cord-019001-ralxw4ad	446	102	in	in	IN
cord-019001-ralxw4ad	446	103	endothelial	endothelial	JJ
cord-019001-ralxw4ad	446	104	cytosol	cytosol	NN
cord-019001-ralxw4ad	446	105	:	:	:
cord-019001-ralxw4ad	446	106	evidence	evidence	NN
cord-019001-ralxw4ad	446	107	for	for	IN
cord-019001-ralxw4ad	446	108	a	a	DT
cord-019001-ralxw4ad	446	109	calcium	calcium	NN
cord-019001-ralxw4ad	446	110	-	-	HYPH
cord-019001-ralxw4ad	446	111	dependent	dependent	JJ
cord-019001-ralxw4ad	446	112	and	and	CC
cord-019001-ralxw4ad	446	113	a	a	DT
cord-019001-ralxw4ad	446	114	calcium	calcium	NN
cord-019001-ralxw4ad	446	115	-	-	HYPH
cord-019001-ralxw4ad	446	116	independent	independent	JJ
cord-019001-ralxw4ad	446	117	mechanism	mechanism	NN
cord-019001-ralxw4ad	446	118	Augmentation	augmentation	NN
cord-019001-ralxw4ad	446	119	of	of	IN
cord-019001-ralxw4ad	446	120	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	446	121	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	446	122	vasoconstriction	vasoconstriction	NN
cord-019001-ralxw4ad	446	123	in	in	IN
cord-019001-ralxw4ad	446	124	the	the	DT
cord-019001-ralxw4ad	446	125	isolated	isolated	JJ
cord-019001-ralxw4ad	446	126	perfused	perfuse	VBN
cord-019001-ralxw4ad	446	127	rat	rat	NN
cord-019001-ralxw4ad	446	128	lung	lung	NN
cord-019001-ralxw4ad	446	129	by	by	IN
cord-019001-ralxw4ad	446	130	in	in	FW
cord-019001-ralxw4ad	446	131	vitro	vitro	FW
cord-019001-ralxw4ad	446	132	antagonists	antagonist	NNS
cord-019001-ralxw4ad	446	133	of	of	IN
cord-019001-ralxw4ad	446	134	endothelium	endothelium	NN
cord-019001-ralxw4ad	446	135	-	-	HYPH
cord-019001-ralxw4ad	446	136	dependent	dependent	JJ
cord-019001-ralxw4ad	446	137	relaxation	relaxation	NN
cord-019001-ralxw4ad	446	138	Cloning	cloning	NN
cord-019001-ralxw4ad	446	139	and	and	CC
cord-019001-ralxw4ad	446	140	expression	expression	NN
cord-019001-ralxw4ad	446	141	of	of	IN
cord-019001-ralxw4ad	446	142	a	a	DT
cord-019001-ralxw4ad	446	143	cDNA	cdna	NN
cord-019001-ralxw4ad	446	144	encoding	encode	VBG
cord-019001-ralxw4ad	446	145	an	an	DT
cord-019001-ralxw4ad	446	146	endothelin	endothelin	JJ
cord-019001-ralxw4ad	446	147	receptor	receptor	NN
cord-019001-ralxw4ad	446	148	Cloning	cloning	NN
cord-019001-ralxw4ad	446	149	of	of	IN
cord-019001-ralxw4ad	446	150	a	a	DT
cord-019001-ralxw4ad	446	151	cDNA	cdna	NN
cord-019001-ralxw4ad	446	152	encoding	encode	VBG
cord-019001-ralxw4ad	446	153	a	a	DT
cord-019001-ralxw4ad	446	154	non	non	JJ
cord-019001-ralxw4ad	446	155	-	-	JJ
cord-019001-ralxw4ad	446	156	isopeptide	isopeptide	JJ
cord-019001-ralxw4ad	446	157	-	-	HYPH
cord-019001-ralxw4ad	446	158	selective	selective	JJ
cord-019001-ralxw4ad	446	159	subtype	subtype	NN
cord-019001-ralxw4ad	446	160	of	of	IN
cord-019001-ralxw4ad	446	161	the	the	DT
cord-019001-ralxw4ad	446	162	endothelin	endothelin	NNP
cord-019001-ralxw4ad	446	163	receptor	receptor	NN
cord-019001-ralxw4ad	446	164	Regulatory	Regulatory	NNP
cord-019001-ralxw4ad	446	165	functions	function	NNS
cord-019001-ralxw4ad	446	166	of	of	IN
cord-019001-ralxw4ad	446	167	the	the	DT
cord-019001-ralxw4ad	446	168	vascular	vascular	JJ
cord-019001-ralxw4ad	446	169	endothelium	endothelium	NN
cord-019001-ralxw4ad	446	170	Regulation	regulation	NN
cord-019001-ralxw4ad	446	171	of	of	IN
cord-019001-ralxw4ad	446	172	the	the	DT
cord-019001-ralxw4ad	446	173	cerebral	cerebral	JJ
cord-019001-ralxw4ad	446	174	circulation	circulation	NN
cord-019001-ralxw4ad	446	175	:	:	:
cord-019001-ralxw4ad	446	176	role	role	NN
cord-019001-ralxw4ad	446	177	of	of	IN
cord-019001-ralxw4ad	446	178	endothelium	endothelium	NN
cord-019001-ralxw4ad	446	179	and	and	CC
cord-019001-ralxw4ad	446	180	potassium	potassium	NN
cord-019001-ralxw4ad	446	181	channels	channel	NNS
cord-019001-ralxw4ad	446	182	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	446	183	artery	artery	NN
cord-019001-ralxw4ad	446	184	endothelial	endothelial	JJ
cord-019001-ralxw4ad	446	185	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	446	186	in	in	IN
cord-019001-ralxw4ad	446	187	patients	patient	NNS
cord-019001-ralxw4ad	446	188	with	with	IN
cord-019001-ralxw4ad	446	189	congenital	congenital	JJ
cord-019001-ralxw4ad	446	190	heart	heart	NN
cord-019001-ralxw4ad	446	191	defects	defect	NNS
cord-019001-ralxw4ad	446	192	and	and	CC
cord-019001-ralxw4ad	446	193	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	446	194	hypertension	hypertension	NN
cord-019001-ralxw4ad	446	195	.	.	.
cord-019001-ralxw4ad	447	1	A	a	DT
cord-019001-ralxw4ad	447	2	correlation	correlation	NN
cord-019001-ralxw4ad	447	3	of	of	IN
cord-019001-ralxw4ad	447	4	light	light	NN
cord-019001-ralxw4ad	447	5	with	with	IN
cord-019001-ralxw4ad	447	6	scanning	scan	VBG
cord-019001-ralxw4ad	447	7	electron	electron	NN
cord-019001-ralxw4ad	447	8	microscopy	microscopy	NN
cord-019001-ralxw4ad	447	9	and	and	CC
cord-019001-ralxw4ad	447	10	transmission	transmission	NN
cord-019001-ralxw4ad	447	11	electron	electron	NN
cord-019001-ralxw4ad	447	12	microscopy	microscopy	NN
cord-019001-ralxw4ad	447	13	Impairment	impairment	NN
cord-019001-ralxw4ad	447	14	of	of	IN
cord-019001-ralxw4ad	447	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	447	16	endothelium	endothelium	NN
cord-019001-ralxw4ad	447	17	-	-	HYPH
cord-019001-ralxw4ad	447	18	dependent	dependent	JJ
cord-019001-ralxw4ad	447	19	relaxation	relaxation	NN
cord-019001-ralxw4ad	447	20	in	in	IN
cord-019001-ralxw4ad	447	21	patients	patient	NNS
cord-019001-ralxw4ad	447	22	with	with	IN
cord-019001-ralxw4ad	447	23	Eisenmenger	Eisenmenger	NNP
cord-019001-ralxw4ad	447	24	's	's	POS
cord-019001-ralxw4ad	447	25	syndrome	syndrome	NN
cord-019001-ralxw4ad	447	26	Development	Development	NNP
cord-019001-ralxw4ad	447	27	of	of	IN
cord-019001-ralxw4ad	447	28	Crotalaria	Crotalaria	NNP
cord-019001-ralxw4ad	447	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	447	30	hypertension	hypertension	NN
cord-019001-ralxw4ad	447	31	:	:	:
cord-019001-ralxw4ad	447	32	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	447	33	and	and	CC
cord-019001-ralxw4ad	447	34	structural	structural	JJ
cord-019001-ralxw4ad	447	35	study	study	NN
cord-019001-ralxw4ad	447	36	Plasma	Plasma	NNP
cord-019001-ralxw4ad	447	37	endothelin	endothelin	JJ
cord-019001-ralxw4ad	447	38	concentrations	concentration	NNS
cord-019001-ralxw4ad	447	39	in	in	IN
cord-019001-ralxw4ad	447	40	patients	patient	NNS
cord-019001-ralxw4ad	447	41	with	with	IN
cord-019001-ralxw4ad	447	42	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	447	43	hypertension	hypertension	NN
cord-019001-ralxw4ad	447	44	associated	associate	VBN
cord-019001-ralxw4ad	447	45	with	with	IN
cord-019001-ralxw4ad	447	46	congenital	congenital	JJ
cord-019001-ralxw4ad	447	47	heart	heart	NN
cord-019001-ralxw4ad	447	48	defects	defect	NNS
cord-019001-ralxw4ad	447	49	.	.	.
cord-019001-ralxw4ad	448	1	Evidence	evidence	NN
cord-019001-ralxw4ad	448	2	for	for	IN
cord-019001-ralxw4ad	448	3	increased	increased	JJ
cord-019001-ralxw4ad	448	4	production	production	NN
cord-019001-ralxw4ad	448	5	of	of	IN
cord-019001-ralxw4ad	448	6	endothelin	endothelin	NN
cord-019001-ralxw4ad	448	7	in	in	IN
cord-019001-ralxw4ad	448	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	448	9	circulation	circulation	NN
cord-019001-ralxw4ad	449	1	Heterozygous	heterozygous	JJ
cord-019001-ralxw4ad	449	2	germline	germline	NN
cord-019001-ralxw4ad	449	3	mutations	mutation	NNS
cord-019001-ralxw4ad	449	4	in	in	IN
cord-019001-ralxw4ad	449	5	BMPR2	bmpr2	NN
cord-019001-ralxw4ad	449	6	,	,	,
cord-019001-ralxw4ad	449	7	encoding	encode	VBG
cord-019001-ralxw4ad	449	8	a	a	DT
cord-019001-ralxw4ad	449	9	TGF	TGF	NNP
cord-019001-ralxw4ad	449	10	-	-	HYPH
cord-019001-ralxw4ad	449	11	beta	beta	NN
cord-019001-ralxw4ad	449	12	receptor	receptor	NN
cord-019001-ralxw4ad	449	13	,	,	,
cord-019001-ralxw4ad	450	1	cause	cause	VB
cord-019001-ralxw4ad	450	2	familial	familial	JJ
cord-019001-ralxw4ad	450	3	primary	primary	JJ
cord-019001-ralxw4ad	450	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	450	5	hypertension	hypertension	NN
cord-019001-ralxw4ad	450	6	.	.	.
cord-019001-ralxw4ad	451	1	The	the	DT
cord-019001-ralxw4ad	451	2	International	International	NNP
cord-019001-ralxw4ad	451	3	PPH	PPH	NNP
cord-019001-ralxw4ad	451	4	Consortium	Consortium	NNP
cord-019001-ralxw4ad	451	5	Sporadic	sporadic	JJ
cord-019001-ralxw4ad	451	6	primary	primary	JJ
cord-019001-ralxw4ad	451	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	451	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	451	9	is	be	VBZ
cord-019001-ralxw4ad	451	10	associated	associate	VBN
cord-019001-ralxw4ad	451	11	with	with	IN
cord-019001-ralxw4ad	451	12	germline	germline	JJ
cord-019001-ralxw4ad	451	13	mutations	mutation	NNS
cord-019001-ralxw4ad	451	14	of	of	IN
cord-019001-ralxw4ad	451	15	the	the	DT
cord-019001-ralxw4ad	451	16	gene	gene	NN
cord-019001-ralxw4ad	451	17	encoding	encode	VBG
cord-019001-ralxw4ad	451	18	BMPR	BMPR	NNP
cord-019001-ralxw4ad	451	19	-	-	HYPH
cord-019001-ralxw4ad	451	20	II	II	NNP
cord-019001-ralxw4ad	451	21	,	,	,
cord-019001-ralxw4ad	451	22	a	a	DT
cord-019001-ralxw4ad	451	23	receptor	receptor	NN
cord-019001-ralxw4ad	451	24	member	member	NN
cord-019001-ralxw4ad	451	25	of	of	IN
cord-019001-ralxw4ad	451	26	the	the	DT
cord-019001-ralxw4ad	451	27	TGF	TGF	NNP
cord-019001-ralxw4ad	451	28	-	-	HYPH
cord-019001-ralxw4ad	451	29	beta	beta	NN
cord-019001-ralxw4ad	451	30	family	family	NN
cord-019001-ralxw4ad	451	31	Mutation	Mutation	NNP
cord-019001-ralxw4ad	451	32	in	in	IN
cord-019001-ralxw4ad	451	33	the	the	DT
cord-019001-ralxw4ad	451	34	gene	gene	NN
cord-019001-ralxw4ad	451	35	for	for	IN
cord-019001-ralxw4ad	451	36	bone	bone	NN
cord-019001-ralxw4ad	451	37	morphogenetic	morphogenetic	JJ
cord-019001-ralxw4ad	451	38	protein	protein	NN
cord-019001-ralxw4ad	451	39	receptor	receptor	NN
cord-019001-ralxw4ad	451	40	II	II	NNP
cord-019001-ralxw4ad	451	41	as	as	IN
cord-019001-ralxw4ad	451	42	a	a	DT
cord-019001-ralxw4ad	451	43	cause	cause	NN
cord-019001-ralxw4ad	451	44	of	of	IN
cord-019001-ralxw4ad	451	45	primary	primary	JJ
cord-019001-ralxw4ad	451	46	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	451	47	hypertension	hypertension	NN
cord-019001-ralxw4ad	451	48	in	in	IN
cord-019001-ralxw4ad	451	49	a	a	DT
cord-019001-ralxw4ad	451	50	large	large	JJ
cord-019001-ralxw4ad	451	51	kindred	kindred	JJ
cord-019001-ralxw4ad	451	52	BMPR2	bmpr2	XX
cord-019001-ralxw4ad	451	53	germline	germline	NN
cord-019001-ralxw4ad	451	54	mutations	mutation	NNS
cord-019001-ralxw4ad	451	55	in	in	IN
cord-019001-ralxw4ad	451	56	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	451	57	hypertension	hypertension	NN
cord-019001-ralxw4ad	451	58	associated	associate	VBN
cord-019001-ralxw4ad	451	59	with	with	IN
cord-019001-ralxw4ad	451	60	fenfl	fenfl	NN
cord-019001-ralxw4ad	451	61	uramine	uramine	NNP
cord-019001-ralxw4ad	451	62	derivatives	derivative	NNS
cord-019001-ralxw4ad	451	63	Lung	Lung	NNP
cord-019001-ralxw4ad	451	64	biopsy	biopsy	NN
cord-019001-ralxw4ad	451	65	in	in	IN
cord-019001-ralxw4ad	451	66	congenital	congenital	JJ
cord-019001-ralxw4ad	451	67	heart	heart	NN
cord-019001-ralxw4ad	451	68	disease	disease	NN
cord-019001-ralxw4ad	451	69	:	:	:
cord-019001-ralxw4ad	451	70	a	a	DT
cord-019001-ralxw4ad	451	71	morphometric	morphometric	JJ
cord-019001-ralxw4ad	451	72	approach	approach	NN
cord-019001-ralxw4ad	451	73	to	to	IN
cord-019001-ralxw4ad	451	74	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	451	75	vascular	vascular	JJ
cord-019001-ralxw4ad	451	76	disease	disease	NN
cord-019001-ralxw4ad	451	77	Ultrastructural	Ultrastructural	NNP
cord-019001-ralxw4ad	451	78	fi	fi	IN
cord-019001-ralxw4ad	451	79	ndings	nding	NNS
cord-019001-ralxw4ad	451	80	in	in	IN
cord-019001-ralxw4ad	451	81	lung	lung	NN
cord-019001-ralxw4ad	451	82	biopsy	biopsy	NN
cord-019001-ralxw4ad	451	83	material	material	NN
cord-019001-ralxw4ad	451	84	from	from	IN
cord-019001-ralxw4ad	451	85	children	child	NNS
cord-019001-ralxw4ad	451	86	with	with	IN
cord-019001-ralxw4ad	451	87	congenital	congenital	JJ
cord-019001-ralxw4ad	451	88	heart	heart	NN
cord-019001-ralxw4ad	451	89	defects	defect	NNS
cord-019001-ralxw4ad	452	1	Quantitative	quantitative	JJ
cord-019001-ralxw4ad	452	2	structural	structural	JJ
cord-019001-ralxw4ad	452	3	analysis	analysis	NN
cord-019001-ralxw4ad	452	4	of	of	IN
cord-019001-ralxw4ad	452	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	452	6	vessels	vessel	NNS
cord-019001-ralxw4ad	452	7	in	in	IN
cord-019001-ralxw4ad	452	8	isolated	isolate	VBN
cord-019001-ralxw4ad	452	9	ventricular	ventricular	JJ
cord-019001-ralxw4ad	452	10	septal	septal	JJ
cord-019001-ralxw4ad	452	11	defect	defect	NN
cord-019001-ralxw4ad	452	12	in	in	IN
cord-019001-ralxw4ad	452	13	infancy	infancy	NN
cord-019001-ralxw4ad	453	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	453	2	vascular	vascular	JJ
cord-019001-ralxw4ad	453	3	disease	disease	NN
cord-019001-ralxw4ad	453	4	in	in	IN
cord-019001-ralxw4ad	453	5	different	different	JJ
cord-019001-ralxw4ad	453	6	types	type	NNS
cord-019001-ralxw4ad	453	7	of	of	IN
cord-019001-ralxw4ad	453	8	congenital	congenital	JJ
cord-019001-ralxw4ad	453	9	heart	heart	NN
cord-019001-ralxw4ad	453	10	disease	disease	NN
cord-019001-ralxw4ad	453	11	.	.	.
cord-019001-ralxw4ad	454	1	Implications	implication	NNS
cord-019001-ralxw4ad	454	2	for	for	IN
cord-019001-ralxw4ad	454	3	interpretation	interpretation	NN
cord-019001-ralxw4ad	454	4	of	of	IN
cord-019001-ralxw4ad	454	5	lung	lung	NN
cord-019001-ralxw4ad	454	6	biopsy	biopsy	NNP
cord-019001-ralxw4ad	454	7	fi	fi	NNP
cord-019001-ralxw4ad	454	8	ndings	nding	NNS
cord-019001-ralxw4ad	454	9	in	in	IN
cord-019001-ralxw4ad	454	10	early	early	JJ
cord-019001-ralxw4ad	454	11	childhood	childhood	NN
cord-019001-ralxw4ad	454	12	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	454	13	vascular	vascular	JJ
cord-019001-ralxw4ad	454	14	disease	disease	NN
cord-019001-ralxw4ad	454	15	with	with	IN
cord-019001-ralxw4ad	454	16	congenital	congenital	JJ
cord-019001-ralxw4ad	454	17	heart	heart	NN
cord-019001-ralxw4ad	454	18	lesions	lesion	NNS
cord-019001-ralxw4ad	454	19	:	:	:
cord-019001-ralxw4ad	454	20	pathologic	pathologic	JJ
cord-019001-ralxw4ad	454	21	features	feature	NNS
cord-019001-ralxw4ad	454	22	and	and	CC
cord-019001-ralxw4ad	454	23	causes	cause	VBZ
cord-019001-ralxw4ad	454	24	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	454	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	454	26	in	in	IN
cord-019001-ralxw4ad	454	27	children	child	NNS
cord-019001-ralxw4ad	454	28	:	:	:
cord-019001-ralxw4ad	454	29	perioperative	perioperative	JJ
cord-019001-ralxw4ad	454	30	management	management	NN
cord-019001-ralxw4ad	454	31	Diagnosis	diagnosis	NN
cord-019001-ralxw4ad	454	32	and	and	CC
cord-019001-ralxw4ad	454	33	management	management	NN
cord-019001-ralxw4ad	454	34	of	of	IN
cord-019001-ralxw4ad	454	35	postoperative	postoperative	JJ
cord-019001-ralxw4ad	454	36	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	454	37	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	454	38	crisis	crisis	NN
cord-019001-ralxw4ad	455	1	Transient	transient	JJ
cord-019001-ralxw4ad	455	2	myocardial	myocardial	JJ
cord-019001-ralxw4ad	455	3	ischemia	ischemia	NN
cord-019001-ralxw4ad	455	4	of	of	IN
cord-019001-ralxw4ad	455	5	the	the	DT
cord-019001-ralxw4ad	455	6	newborn	newborn	JJ
cord-019001-ralxw4ad	455	7	infant	infant	NN
cord-019001-ralxw4ad	455	8	:	:	:
cord-019001-ralxw4ad	455	9	a	a	DT
cord-019001-ralxw4ad	455	10	form	form	NN
cord-019001-ralxw4ad	455	11	of	of	IN
cord-019001-ralxw4ad	455	12	severe	severe	JJ
cord-019001-ralxw4ad	455	13	cardiorespiratory	cardiorespiratory	JJ
cord-019001-ralxw4ad	455	14	distress	distress	NN
cord-019001-ralxw4ad	455	15	in	in	IN
cord-019001-ralxw4ad	455	16	full	full	JJ
cord-019001-ralxw4ad	455	17	-	-	HYPH
cord-019001-ralxw4ad	455	18	term	term	NN
cord-019001-ralxw4ad	455	19	infants	infant	NNS
cord-019001-ralxw4ad	455	20	Persistence	persistence	NN
cord-019001-ralxw4ad	455	21	of	of	IN
cord-019001-ralxw4ad	455	22	atrioventricular	atrioventricular	JJ
cord-019001-ralxw4ad	455	23	valve	valve	NN
cord-019001-ralxw4ad	455	24	regurgitation	regurgitation	NN
cord-019001-ralxw4ad	455	25	and	and	CC
cord-019001-ralxw4ad	455	26	electrocardiographic	electrocardiographic	JJ
cord-019001-ralxw4ad	455	27	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	455	28	following	follow	VBG
cord-019001-ralxw4ad	455	29	transient	transient	JJ
cord-019001-ralxw4ad	455	30	myocardial	myocardial	JJ
cord-019001-ralxw4ad	455	31	ischemia	ischemia	NN
cord-019001-ralxw4ad	455	32	of	of	IN
cord-019001-ralxw4ad	455	33	the	the	DT
cord-019001-ralxw4ad	455	34	newborn	newborn	JJ
cord-019001-ralxw4ad	455	35	Lung	Lung	NNP
cord-019001-ralxw4ad	455	36	mechanics	mechanic	NNS
cord-019001-ralxw4ad	455	37	in	in	IN
cord-019001-ralxw4ad	455	38	congenital	congenital	JJ
cord-019001-ralxw4ad	455	39	heart	heart	NN
cord-019001-ralxw4ad	455	40	disease	disease	NN
cord-019001-ralxw4ad	455	41	with	with	IN
cord-019001-ralxw4ad	455	42	increased	increase	VBN
cord-019001-ralxw4ad	455	43	and	and	CC
cord-019001-ralxw4ad	455	44	decreased	decrease	VBD
cord-019001-ralxw4ad	455	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	455	46	blood	blood	NN
cord-019001-ralxw4ad	455	47	fl	fl	NNP
cord-019001-ralxw4ad	456	1	ow	ow	UH
cord-019001-ralxw4ad	457	1	A	a	DT
cord-019001-ralxw4ad	457	2	randomized	randomized	JJ
cord-019001-ralxw4ad	457	3	,	,	,
cord-019001-ralxw4ad	457	4	controlled	controlled	JJ
cord-019001-ralxw4ad	457	5	study	study	NN
cord-019001-ralxw4ad	457	6	of	of	IN
cord-019001-ralxw4ad	457	7	the	the	DT
cord-019001-ralxw4ad	457	8	1-hour	1-hour	CD
cord-019001-ralxw4ad	457	9	and	and	CC
cord-019001-ralxw4ad	457	10	24-hour	24-hour	JJ
cord-019001-ralxw4ad	457	11	effects	effect	NNS
cord-019001-ralxw4ad	457	12	of	of	IN
cord-019001-ralxw4ad	457	13	inhaled	inhale	VBN
cord-019001-ralxw4ad	457	14	nitric	nitric	NN
cord-019001-ralxw4ad	457	15	oxide	oxide	NN
cord-019001-ralxw4ad	457	16	therapy	therapy	NN
cord-019001-ralxw4ad	457	17	in	in	IN
cord-019001-ralxw4ad	457	18	children	child	NNS
cord-019001-ralxw4ad	457	19	with	with	IN
cord-019001-ralxw4ad	457	20	acute	acute	JJ
cord-019001-ralxw4ad	457	21	hypoxemic	hypoxemic	JJ
cord-019001-ralxw4ad	457	22	respiratory	respiratory	JJ
cord-019001-ralxw4ad	457	23	failure	failure	NN
cord-019001-ralxw4ad	458	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	458	2	nitric	nitric	NN
cord-019001-ralxw4ad	458	3	oxide	oxide	NN
cord-019001-ralxw4ad	458	4	in	in	IN
cord-019001-ralxw4ad	458	5	full	full	JJ
cord-019001-ralxw4ad	458	6	-	-	HYPH
cord-019001-ralxw4ad	458	7	term	term	NN
cord-019001-ralxw4ad	458	8	and	and	CC
cord-019001-ralxw4ad	458	9	nearly	nearly	RB
cord-019001-ralxw4ad	458	10	full	full	JJ
cord-019001-ralxw4ad	458	11	-	-	HYPH
cord-019001-ralxw4ad	458	12	term	term	NN
cord-019001-ralxw4ad	458	13	infants	infant	NNS
cord-019001-ralxw4ad	458	14	with	with	IN
cord-019001-ralxw4ad	458	15	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	458	16	respiratory	respiratory	JJ
cord-019001-ralxw4ad	458	17	failure	failure	NN
cord-019001-ralxw4ad	458	18	.	.	.
cord-019001-ralxw4ad	459	1	The	the	DT
cord-019001-ralxw4ad	459	2	Neonatal	Neonatal	NNP
cord-019001-ralxw4ad	459	3	Inhaled	Inhaled	NNP
cord-019001-ralxw4ad	459	4	Nitric	Nitric	NNP
cord-019001-ralxw4ad	459	5	Oxide	Oxide	NNP
cord-019001-ralxw4ad	459	6	Study	Study	NNP
cord-019001-ralxw4ad	459	7	Group	Group	NNP
cord-019001-ralxw4ad	459	8	Inhaled	Inhaled	NNP
cord-019001-ralxw4ad	459	9	nitric	nitric	JJ
cord-019001-ralxw4ad	459	10	oxide	oxide	NN
cord-019001-ralxw4ad	459	11	in	in	IN
cord-019001-ralxw4ad	459	12	the	the	DT
cord-019001-ralxw4ad	459	13	neonate	neonate	NN
cord-019001-ralxw4ad	459	14	with	with	IN
cord-019001-ralxw4ad	459	15	cardiac	cardiac	JJ
cord-019001-ralxw4ad	459	16	disease	disease	NN
cord-019001-ralxw4ad	459	17	Low	low	JJ
cord-019001-ralxw4ad	459	18	-	-	HYPH
cord-019001-ralxw4ad	459	19	dose	dose	NN
cord-019001-ralxw4ad	459	20	nitric	nitric	NN
cord-019001-ralxw4ad	459	21	oxide	oxide	NN
cord-019001-ralxw4ad	459	22	therapy	therapy	NN
cord-019001-ralxw4ad	459	23	for	for	IN
cord-019001-ralxw4ad	459	24	persistent	persistent	JJ
cord-019001-ralxw4ad	459	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	459	26	hypertension	hypertension	NN
cord-019001-ralxw4ad	459	27	of	of	IN
cord-019001-ralxw4ad	459	28	the	the	DT
cord-019001-ralxw4ad	459	29	newborn	newborn	NN
cord-019001-ralxw4ad	459	30	.	.	.
cord-019001-ralxw4ad	460	1	Clinical	Clinical	NNP
cord-019001-ralxw4ad	460	2	Inhaled	Inhaled	NNP
cord-019001-ralxw4ad	460	3	Nitric	Nitric	NNP
cord-019001-ralxw4ad	460	4	Oxide	Oxide	NNP
cord-019001-ralxw4ad	460	5	Research	Research	NNP
cord-019001-ralxw4ad	460	6	Group	Group	NNP
cord-019001-ralxw4ad	460	7	Effects	Effects	NNPS
cord-019001-ralxw4ad	460	8	of	of	IN
cord-019001-ralxw4ad	460	9	inhaled	inhale	VBN
cord-019001-ralxw4ad	460	10	nitric	nitric	NN
cord-019001-ralxw4ad	460	11	oxide	oxide	NN
cord-019001-ralxw4ad	460	12	in	in	IN
cord-019001-ralxw4ad	460	13	patients	patient	NNS
cord-019001-ralxw4ad	460	14	with	with	IN
cord-019001-ralxw4ad	460	15	acute	acute	JJ
cord-019001-ralxw4ad	460	16	respiratory	respiratory	JJ
cord-019001-ralxw4ad	460	17	distress	distress	NN
cord-019001-ralxw4ad	460	18	syndrome	syndrome	NN
cord-019001-ralxw4ad	460	19	:	:	:
cord-019001-ralxw4ad	460	20	results	result	NNS
cord-019001-ralxw4ad	460	21	of	of	IN
cord-019001-ralxw4ad	460	22	a	a	DT
cord-019001-ralxw4ad	460	23	randomized	randomized	JJ
cord-019001-ralxw4ad	460	24	phase	phase	NN
cord-019001-ralxw4ad	460	25	II	II	NNP
cord-019001-ralxw4ad	460	26	trial	trial	NN
cord-019001-ralxw4ad	460	27	.	.	.
cord-019001-ralxw4ad	461	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	461	2	Nitric	nitric	NN
cord-019001-ralxw4ad	461	3	Oxide	Oxide	NNP
cord-019001-ralxw4ad	461	4	in	in	IN
cord-019001-ralxw4ad	461	5	ARDS	ARDS	NNP
cord-019001-ralxw4ad	461	6	Study	Study	NNP
cord-019001-ralxw4ad	461	7	Group	Group	NNP
cord-019001-ralxw4ad	461	8	Multicenter	Multicenter	NNP
cord-019001-ralxw4ad	461	9	randomized	randomize	VBD
cord-019001-ralxw4ad	461	10	controlled	control	VBN
cord-019001-ralxw4ad	461	11	trial	trial	NN
cord-019001-ralxw4ad	461	12	of	of	IN
cord-019001-ralxw4ad	461	13	the	the	DT
cord-019001-ralxw4ad	461	14	effects	effect	NNS
cord-019001-ralxw4ad	461	15	of	of	IN
cord-019001-ralxw4ad	461	16	inhaled	inhale	VBN
cord-019001-ralxw4ad	461	17	nitric	nitric	NN
cord-019001-ralxw4ad	461	18	oxide	oxide	NN
cord-019001-ralxw4ad	461	19	therapy	therapy	NN
cord-019001-ralxw4ad	461	20	on	on	IN
cord-019001-ralxw4ad	461	21	gas	gas	NN
cord-019001-ralxw4ad	461	22	exchange	exchange	NN
cord-019001-ralxw4ad	461	23	in	in	IN
cord-019001-ralxw4ad	461	24	children	child	NNS
cord-019001-ralxw4ad	461	25	with	with	IN
cord-019001-ralxw4ad	461	26	acute	acute	JJ
cord-019001-ralxw4ad	461	27	hypoxemic	hypoxemic	JJ
cord-019001-ralxw4ad	461	28	respiratory	respiratory	JJ
cord-019001-ralxw4ad	461	29	failure	failure	NN
cord-019001-ralxw4ad	462	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	462	2	nitric	nitric	NN
cord-019001-ralxw4ad	462	3	oxide	oxide	NN
cord-019001-ralxw4ad	462	4	therapy	therapy	NN
cord-019001-ralxw4ad	462	5	for	for	IN
cord-019001-ralxw4ad	462	6	persistent	persistent	JJ
cord-019001-ralxw4ad	462	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	462	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	462	9	of	of	IN
cord-019001-ralxw4ad	462	10	the	the	DT
cord-019001-ralxw4ad	462	11	newborn	newborn	JJ
cord-019001-ralxw4ad	462	12	Inhaled	inhale	VBN
cord-019001-ralxw4ad	462	13	nitric	nitric	NN
cord-019001-ralxw4ad	462	14	oxide	oxide	NN
cord-019001-ralxw4ad	462	15	in	in	IN
cord-019001-ralxw4ad	462	16	congenital	congenital	JJ
cord-019001-ralxw4ad	462	17	hypoplasia	hypoplasia	NN
cord-019001-ralxw4ad	462	18	of	of	IN
cord-019001-ralxw4ad	462	19	the	the	DT
cord-019001-ralxw4ad	462	20	lungs	lung	NNS
cord-019001-ralxw4ad	462	21	due	due	JJ
cord-019001-ralxw4ad	462	22	to	to	IN
cord-019001-ralxw4ad	462	23	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	462	24	hernia	hernia	NN
cord-019001-ralxw4ad	462	25	or	or	CC
cord-019001-ralxw4ad	462	26	oligohydramnios	oligohydramnios	NNP
cord-019001-ralxw4ad	462	27	Randomized	randomized	JJ
cord-019001-ralxw4ad	462	28	,	,	,
cord-019001-ralxw4ad	462	29	multicenter	multicenter	JJ
cord-019001-ralxw4ad	462	30	trial	trial	NN
cord-019001-ralxw4ad	462	31	of	of	IN
cord-019001-ralxw4ad	462	32	inhaled	inhale	VBN
cord-019001-ralxw4ad	462	33	nitric	nitric	NN
cord-019001-ralxw4ad	462	34	oxide	oxide	NN
cord-019001-ralxw4ad	462	35	and	and	CC
cord-019001-ralxw4ad	462	36	high	high	JJ
cord-019001-ralxw4ad	462	37	-	-	HYPH
cord-019001-ralxw4ad	462	38	frequency	frequency	NN
cord-019001-ralxw4ad	462	39	oscillatory	oscillatory	JJ
cord-019001-ralxw4ad	462	40	ventilation	ventilation	NN
cord-019001-ralxw4ad	462	41	in	in	IN
cord-019001-ralxw4ad	462	42	severe	severe	JJ
cord-019001-ralxw4ad	462	43	,	,	,
cord-019001-ralxw4ad	462	44	persistent	persistent	JJ
cord-019001-ralxw4ad	462	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	462	46	hypertension	hypertension	NN
cord-019001-ralxw4ad	462	47	of	of	IN
cord-019001-ralxw4ad	462	48	the	the	DT
cord-019001-ralxw4ad	462	49	newborn	newborn	JJ
cord-019001-ralxw4ad	462	50	Inhaled	inhale	VBN
cord-019001-ralxw4ad	462	51	nitric	nitric	NN
cord-019001-ralxw4ad	462	52	oxide	oxide	NN
cord-019001-ralxw4ad	462	53	therapy	therapy	NN
cord-019001-ralxw4ad	462	54	Inhaled	inhale	VBD
cord-019001-ralxw4ad	462	55	nitric	nitric	NN
cord-019001-ralxw4ad	462	56	oxide	oxide	NN
cord-019001-ralxw4ad	462	57	and	and	CC
cord-019001-ralxw4ad	462	58	persistent	persistent	JJ
cord-019001-ralxw4ad	462	59	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	462	60	hypertension	hypertension	NN
cord-019001-ralxw4ad	462	61	of	of	IN
cord-019001-ralxw4ad	462	62	the	the	DT
cord-019001-ralxw4ad	462	63	newborn	newborn	NN
cord-019001-ralxw4ad	462	64	.	.	.
cord-019001-ralxw4ad	463	1	The	the	DT
cord-019001-ralxw4ad	463	2	Inhaled	Inhaled	NNP
cord-019001-ralxw4ad	463	3	Nitric	Nitric	NNP
cord-019001-ralxw4ad	463	4	Oxide	Oxide	NNP
cord-019001-ralxw4ad	463	5	Study	Study	NNP
cord-019001-ralxw4ad	463	6	Group	Group	NNP
cord-019001-ralxw4ad	464	1	The	the	DT
cord-019001-ralxw4ad	464	2	effects	effect	NNS
cord-019001-ralxw4ad	464	3	of	of	IN
cord-019001-ralxw4ad	464	4	inhaled	inhale	VBN
cord-019001-ralxw4ad	464	5	nitric	nitric	NN
cord-019001-ralxw4ad	464	6	oxide	oxide	NN
cord-019001-ralxw4ad	464	7	on	on	IN
cord-019001-ralxw4ad	464	8	postoperative	postoperative	JJ
cord-019001-ralxw4ad	464	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	464	10	hypertension	hypertension	NN
cord-019001-ralxw4ad	464	11	in	in	IN
cord-019001-ralxw4ad	464	12	infants	infant	NNS
cord-019001-ralxw4ad	464	13	and	and	CC
cord-019001-ralxw4ad	464	14	children	child	NNS
cord-019001-ralxw4ad	464	15	undergoing	undergo	VBG
cord-019001-ralxw4ad	464	16	surgical	surgical	JJ
cord-019001-ralxw4ad	464	17	repair	repair	NN
cord-019001-ralxw4ad	464	18	of	of	IN
cord-019001-ralxw4ad	464	19	congenital	congenital	JJ
cord-019001-ralxw4ad	464	20	heart	heart	NN
cord-019001-ralxw4ad	464	21	disease	disease	NN
cord-019001-ralxw4ad	464	22	Inhaled	inhale	VBD
cord-019001-ralxw4ad	464	23	nitric	nitric	JJ
cord-019001-ralxw4ad	464	24	oxide	oxide	NN
cord-019001-ralxw4ad	464	25	in	in	IN
cord-019001-ralxw4ad	464	26	premature	premature	JJ
cord-019001-ralxw4ad	464	27	infants	infant	NNS
cord-019001-ralxw4ad	464	28	with	with	IN
cord-019001-ralxw4ad	464	29	the	the	DT
cord-019001-ralxw4ad	464	30	respiratory	respiratory	JJ
cord-019001-ralxw4ad	464	31	distress	distress	NN
cord-019001-ralxw4ad	464	32	syndrome	syndrome	NN
cord-019001-ralxw4ad	464	33	Inhaled	inhale	VBD
cord-019001-ralxw4ad	464	34	nitric	nitric	JJ
cord-019001-ralxw4ad	464	35	oxide	oxide	NN
cord-019001-ralxw4ad	464	36	,	,	,
cord-019001-ralxw4ad	464	37	oxygen	oxygen	NN
cord-019001-ralxw4ad	464	38	,	,	,
cord-019001-ralxw4ad	464	39	and	and	CC
cord-019001-ralxw4ad	464	40	alkalosis	alkalosis	NN
cord-019001-ralxw4ad	464	41	:	:	:
cord-019001-ralxw4ad	464	42	dose	dose	NN
cord-019001-ralxw4ad	464	43	-	-	HYPH
cord-019001-ralxw4ad	464	44	response	response	NN
cord-019001-ralxw4ad	464	45	interactions	interaction	NNS
cord-019001-ralxw4ad	464	46	in	in	IN
cord-019001-ralxw4ad	464	47	a	a	DT
cord-019001-ralxw4ad	464	48	lamb	lamb	NN
cord-019001-ralxw4ad	464	49	model	model	NN
cord-019001-ralxw4ad	464	50	of	of	IN
cord-019001-ralxw4ad	464	51	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	464	52	hypertension	hypertension	NN
cord-019001-ralxw4ad	464	53	Effects	effect	NNS
cord-019001-ralxw4ad	464	54	of	of	IN
cord-019001-ralxw4ad	464	55	nitroprusside	nitroprusside	NN
cord-019001-ralxw4ad	464	56	and	and	CC
cord-019001-ralxw4ad	464	57	dopamine	dopamine	NN
cord-019001-ralxw4ad	464	58	on	on	IN
cord-019001-ralxw4ad	464	59	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	464	60	arterial	arterial	JJ
cord-019001-ralxw4ad	464	61	vasculature	vasculature	NN
cord-019001-ralxw4ad	464	62	in	in	IN
cord-019001-ralxw4ad	464	63	children	child	NNS
cord-019001-ralxw4ad	464	64	after	after	IN
cord-019001-ralxw4ad	464	65	cardiac	cardiac	JJ
cord-019001-ralxw4ad	464	66	surgery	surgery	NN
cord-019001-ralxw4ad	464	67	Comparison	comparison	NN
cord-019001-ralxw4ad	464	68	of	of	IN
cord-019001-ralxw4ad	464	69	effects	effect	NNS
cord-019001-ralxw4ad	464	70	of	of	IN
cord-019001-ralxw4ad	464	71	prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	464	72	E1	e1	NN
cord-019001-ralxw4ad	464	73	and	and	CC
cord-019001-ralxw4ad	464	74	nitroprusside	nitroprusside	NN
cord-019001-ralxw4ad	464	75	on	on	IN
cord-019001-ralxw4ad	464	76	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	464	77	vascular	vascular	JJ
cord-019001-ralxw4ad	464	78	resistance	resistance	NN
cord-019001-ralxw4ad	464	79	in	in	IN
cord-019001-ralxw4ad	464	80	children	child	NNS
cord-019001-ralxw4ad	464	81	after	after	IN
cord-019001-ralxw4ad	464	82	open	open	JJ
cord-019001-ralxw4ad	464	83	-	-	HYPH
cord-019001-ralxw4ad	464	84	heart	heart	NN
cord-019001-ralxw4ad	464	85	surgery	surgery	NN
cord-019001-ralxw4ad	464	86	Hemodynamic	Hemodynamic	NNP
cord-019001-ralxw4ad	464	87	effects	effect	NNS
cord-019001-ralxw4ad	464	88	of	of	IN
cord-019001-ralxw4ad	464	89	nifedipine	nifedipine	NN
cord-019001-ralxw4ad	464	90	and	and	CC
cord-019001-ralxw4ad	464	91	oxygen	oxygen	NN
cord-019001-ralxw4ad	464	92	in	in	IN
cord-019001-ralxw4ad	464	93	children	child	NNS
cord-019001-ralxw4ad	464	94	with	with	IN
cord-019001-ralxw4ad	464	95	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	464	96	hypertension	hypertension	NN
cord-019001-ralxw4ad	464	97	.	.	.
cord-019001-ralxw4ad	465	1	Cardiovasc	Cardiovasc	NNP
cord-019001-ralxw4ad	465	2	Does	do	VBZ
cord-019001-ralxw4ad	465	3	prostacyclin	prostacyclin	RB
cord-019001-ralxw4ad	465	4	enhance	enhance	VB
cord-019001-ralxw4ad	465	5	the	the	DT
cord-019001-ralxw4ad	465	6	selective	selective	JJ
cord-019001-ralxw4ad	465	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	465	8	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	465	9	effect	effect	NN
cord-019001-ralxw4ad	465	10	of	of	IN
cord-019001-ralxw4ad	465	11	oxygen	oxygen	NN
cord-019001-ralxw4ad	465	12	in	in	IN
cord-019001-ralxw4ad	465	13	children	child	NNS
cord-019001-ralxw4ad	465	14	with	with	IN
cord-019001-ralxw4ad	465	15	congenital	congenital	JJ
cord-019001-ralxw4ad	465	16	heart	heart	NN
cord-019001-ralxw4ad	465	17	disease	disease	NN
cord-019001-ralxw4ad	465	18	?	?	.
cord-019001-ralxw4ad	466	1	Hemodynamic	Hemodynamic	NNP
cord-019001-ralxw4ad	466	2	effects	effect	NNS
cord-019001-ralxw4ad	466	3	of	of	IN
cord-019001-ralxw4ad	466	4	prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	466	5	E1	e1	NN
cord-019001-ralxw4ad	466	6	in	in	IN
cord-019001-ralxw4ad	466	7	patients	patient	NNS
cord-019001-ralxw4ad	466	8	with	with	IN
cord-019001-ralxw4ad	466	9	congenital	congenital	JJ
cord-019001-ralxw4ad	466	10	heart	heart	NN
cord-019001-ralxw4ad	466	11	disease	disease	NN
cord-019001-ralxw4ad	466	12	and	and	CC
cord-019001-ralxw4ad	466	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	466	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	466	15	Comparison	comparison	NN
cord-019001-ralxw4ad	466	16	between	between	IN
cord-019001-ralxw4ad	466	17	prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	466	18	E1	e1	NN
cord-019001-ralxw4ad	466	19	and	and	CC
cord-019001-ralxw4ad	466	20	epoprostenol	epoprostenol	NNP
cord-019001-ralxw4ad	466	21	(	(	-LRB-
cord-019001-ralxw4ad	466	22	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	466	23	)	)	-RRB-
cord-019001-ralxw4ad	466	24	in	in	IN
cord-019001-ralxw4ad	466	25	infants	infant	NNS
cord-019001-ralxw4ad	466	26	after	after	IN
cord-019001-ralxw4ad	466	27	heart	heart	NN
cord-019001-ralxw4ad	466	28	surgery	surgery	NN
cord-019001-ralxw4ad	466	29	Use	Use	NNP
cord-019001-ralxw4ad	466	30	of	of	IN
cord-019001-ralxw4ad	466	31	ATP	ATP	NNP
cord-019001-ralxw4ad	466	32	-	-	HYPH
cord-019001-ralxw4ad	466	33	MgCl2	mgcl2	NN
cord-019001-ralxw4ad	466	34	in	in	IN
cord-019001-ralxw4ad	466	35	the	the	DT
cord-019001-ralxw4ad	466	36	evaluation	evaluation	NN
cord-019001-ralxw4ad	466	37	and	and	CC
cord-019001-ralxw4ad	466	38	treatment	treatment	NN
cord-019001-ralxw4ad	466	39	of	of	IN
cord-019001-ralxw4ad	466	40	children	child	NNS
cord-019001-ralxw4ad	466	41	with	with	IN
cord-019001-ralxw4ad	466	42	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	466	43	hypertension	hypertension	NN
cord-019001-ralxw4ad	466	44	secondary	secondary	JJ
cord-019001-ralxw4ad	466	45	to	to	IN
cord-019001-ralxw4ad	466	46	congenital	congenital	JJ
cord-019001-ralxw4ad	466	47	heart	heart	NN
cord-019001-ralxw4ad	466	48	defects	defect	NNS
cord-019001-ralxw4ad	467	1	Refractory	refractory	JJ
cord-019001-ralxw4ad	467	2	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	467	3	associated	associate	VBN
cord-019001-ralxw4ad	467	4	with	with	IN
cord-019001-ralxw4ad	467	5	neonatal	neonatal	JJ
cord-019001-ralxw4ad	467	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	467	7	disease	disease	NN
cord-019001-ralxw4ad	467	8	:	:	:
cord-019001-ralxw4ad	467	9	the	the	DT
cord-019001-ralxw4ad	467	10	use	use	NN
cord-019001-ralxw4ad	467	11	and	and	CC
cord-019001-ralxw4ad	467	12	limitations	limitation	NNS
cord-019001-ralxw4ad	467	13	of	of	IN
cord-019001-ralxw4ad	467	14	tolazoline	tolazoline	NN
cord-019001-ralxw4ad	467	15	Hemodynamic	Hemodynamic	NNP
cord-019001-ralxw4ad	467	16	effects	effect	NNS
cord-019001-ralxw4ad	467	17	of	of	IN
cord-019001-ralxw4ad	467	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	467	19	arterial	arterial	JJ
cord-019001-ralxw4ad	467	20	infusion	infusion	NN
cord-019001-ralxw4ad	467	21	of	of	IN
cord-019001-ralxw4ad	467	22	vasodilators	vasodilator	NNS
cord-019001-ralxw4ad	467	23	in	in	IN
cord-019001-ralxw4ad	467	24	newborn	newborn	JJ
cord-019001-ralxw4ad	467	25	lambs	lamb	NNS
cord-019001-ralxw4ad	467	26	Comparative	Comparative	NNP
cord-019001-ralxw4ad	467	27	studies	study	NNS
cord-019001-ralxw4ad	467	28	on	on	IN
cord-019001-ralxw4ad	467	29	the	the	DT
cord-019001-ralxw4ad	467	30	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	467	31	effects	effect	NNS
cord-019001-ralxw4ad	467	32	of	of	IN
cord-019001-ralxw4ad	467	33	prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	467	34	E1	e1	NN
cord-019001-ralxw4ad	467	35	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	467	36	,	,	,
cord-019001-ralxw4ad	467	37	and	and	CC
cord-019001-ralxw4ad	467	38	tolazoline	tolazoline	VB
cord-019001-ralxw4ad	467	39	upon	upon	IN
cord-019001-ralxw4ad	467	40	elevated	elevated	JJ
cord-019001-ralxw4ad	467	41	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	467	42	vascular	vascular	JJ
cord-019001-ralxw4ad	467	43	resistance	resistance	NN
cord-019001-ralxw4ad	467	44	in	in	IN
cord-019001-ralxw4ad	467	45	neonatal	neonatal	JJ
cord-019001-ralxw4ad	467	46	swine	swine	NN
cord-019001-ralxw4ad	467	47	Comparison	comparison	NN
cord-019001-ralxw4ad	467	48	of	of	IN
cord-019001-ralxw4ad	467	49	ketanserin	ketanserin	NNP
cord-019001-ralxw4ad	467	50	and	and	CC
cord-019001-ralxw4ad	467	51	sodium	sodium	NN
cord-019001-ralxw4ad	468	1	nitroprusside	nitroprusside	RB
cord-019001-ralxw4ad	468	2	in	in	IN
cord-019001-ralxw4ad	468	3	patients	patient	NNS
cord-019001-ralxw4ad	468	4	with	with	IN
cord-019001-ralxw4ad	468	5	severe	severe	JJ
cord-019001-ralxw4ad	468	6	ARDS	ARDS	NNP
cord-019001-ralxw4ad	468	7	Prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	468	8	E1	e1	NN
cord-019001-ralxw4ad	468	9	and	and	CC
cord-019001-ralxw4ad	468	10	nitroglycerin	nitroglycerin	NN
cord-019001-ralxw4ad	468	11	reduce	reduce	VBP
cord-019001-ralxw4ad	468	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	468	13	capillary	capillary	JJ
cord-019001-ralxw4ad	468	14	pressure	pressure	NN
cord-019001-ralxw4ad	468	15	but	but	CC
cord-019001-ralxw4ad	468	16	worsen	worsen	VB
cord-019001-ralxw4ad	468	17	ventilation	ventilation	NN
cord-019001-ralxw4ad	468	18	-	-	HYPH
cord-019001-ralxw4ad	468	19	perfusion	perfusion	NN
cord-019001-ralxw4ad	468	20	distributions	distribution	NNS
cord-019001-ralxw4ad	468	21	in	in	IN
cord-019001-ralxw4ad	468	22	patients	patient	NNS
cord-019001-ralxw4ad	468	23	with	with	IN
cord-019001-ralxw4ad	468	24	adult	adult	JJ
cord-019001-ralxw4ad	468	25	respiratory	respiratory	JJ
cord-019001-ralxw4ad	468	26	distress	distress	NN
cord-019001-ralxw4ad	468	27	syndrome	syndrome	NN
cord-019001-ralxw4ad	469	1	The	the	DT
cord-019001-ralxw4ad	469	2	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	469	3	of	of	IN
cord-019001-ralxw4ad	469	4	failure	failure	NN
cord-019001-ralxw4ad	469	5	in	in	IN
cord-019001-ralxw4ad	469	6	acute	acute	JJ
cord-019001-ralxw4ad	469	7	right	right	JJ
cord-019001-ralxw4ad	469	8	ventricular	ventricular	JJ
cord-019001-ralxw4ad	469	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	469	10	:	:	:
cord-019001-ralxw4ad	469	11	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	469	12	and	and	CC
cord-019001-ralxw4ad	469	13	biochemical	biochemical	JJ
cord-019001-ralxw4ad	469	14	correlations	correlation	NNS
cord-019001-ralxw4ad	470	1	Prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	470	2	E1	e1	NN
cord-019001-ralxw4ad	470	3	in	in	IN
cord-019001-ralxw4ad	470	4	the	the	DT
cord-019001-ralxw4ad	470	5	adult	adult	NN
cord-019001-ralxw4ad	470	6	respiratory	respiratory	JJ
cord-019001-ralxw4ad	470	7	distress	distress	NN
cord-019001-ralxw4ad	470	8	syndrome	syndrome	NN
cord-019001-ralxw4ad	470	9	.	.	.
cord-019001-ralxw4ad	471	1	Benefi	Benefi	NNP
cord-019001-ralxw4ad	471	2	t	t	NN
cord-019001-ralxw4ad	471	3	for	for	IN
cord-019001-ralxw4ad	471	4	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	471	5	hypertension	hypertension	NN
cord-019001-ralxw4ad	471	6	and	and	CC
cord-019001-ralxw4ad	471	7	cost	cost	NN
cord-019001-ralxw4ad	471	8	for	for	IN
cord-019001-ralxw4ad	471	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	471	10	gas	gas	NN
cord-019001-ralxw4ad	471	11	exchange	exchange	NN
cord-019001-ralxw4ad	471	12	Prostacyclin	Prostacyclin	NNP
cord-019001-ralxw4ad	471	13	for	for	IN
cord-019001-ralxw4ad	471	14	the	the	DT
cord-019001-ralxw4ad	471	15	treatment	treatment	NN
cord-019001-ralxw4ad	471	16	of	of	IN
cord-019001-ralxw4ad	471	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	471	18	hypertension	hypertension	NN
cord-019001-ralxw4ad	471	19	in	in	IN
cord-019001-ralxw4ad	471	20	the	the	DT
cord-019001-ralxw4ad	471	21	adult	adult	NN
cord-019001-ralxw4ad	471	22	respiratory	respiratory	JJ
cord-019001-ralxw4ad	471	23	distress	distress	NN
cord-019001-ralxw4ad	471	24	syndrome	syndrome	NN
cord-019001-ralxw4ad	471	25	:	:	:
cord-019001-ralxw4ad	471	26	effects	effect	NNS
cord-019001-ralxw4ad	471	27	on	on	IN
cord-019001-ralxw4ad	471	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	471	29	capillary	capillary	JJ
cord-019001-ralxw4ad	471	30	pressure	pressure	NN
cord-019001-ralxw4ad	471	31	and	and	CC
cord-019001-ralxw4ad	471	32	ventilation	ventilation	NN
cord-019001-ralxw4ad	471	33	-	-	HYPH
cord-019001-ralxw4ad	471	34	perfusion	perfusion	NN
cord-019001-ralxw4ad	471	35	distributions	distribution	NNS
cord-019001-ralxw4ad	472	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	472	2	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	472	3	is	be	VBZ
cord-019001-ralxw4ad	472	4	safe	safe	JJ
cord-019001-ralxw4ad	472	5	,	,	,
cord-019001-ralxw4ad	472	6	effective	effective	JJ
cord-019001-ralxw4ad	472	7	,	,	,
cord-019001-ralxw4ad	472	8	and	and	CC
cord-019001-ralxw4ad	472	9	affordable	affordable	JJ
cord-019001-ralxw4ad	472	10	in	in	IN
cord-019001-ralxw4ad	472	11	patients	patient	NNS
cord-019001-ralxw4ad	472	12	with	with	IN
cord-019001-ralxw4ad	472	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	472	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	472	15	,	,	,
cord-019001-ralxw4ad	472	16	right	right	JJ
cord-019001-ralxw4ad	472	17	heart	heart	NN
cord-019001-ralxw4ad	472	18	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	472	19	,	,	,
cord-019001-ralxw4ad	472	20	and	and	CC
cord-019001-ralxw4ad	472	21	refractory	refractory	JJ
cord-019001-ralxw4ad	472	22	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	472	23	after	after	IN
cord-019001-ralxw4ad	472	24	cardiothoracic	cardiothoracic	JJ
cord-019001-ralxw4ad	472	25	surgery	surgery	NN
cord-019001-ralxw4ad	473	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	473	2	epoprostenol	epoprostenol	NNP
cord-019001-ralxw4ad	473	3	(	(	-LRB-
cord-019001-ralxw4ad	473	4	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	473	5	)	)	-RRB-
cord-019001-ralxw4ad	473	6	and	and	CC
cord-019001-ralxw4ad	473	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	473	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	473	9	before	before	IN
cord-019001-ralxw4ad	473	10	cardiac	cardiac	JJ
cord-019001-ralxw4ad	473	11	surgery	surgery	NN
cord-019001-ralxw4ad	474	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	474	2	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	474	3	for	for	IN
cord-019001-ralxw4ad	474	4	term	term	NN
cord-019001-ralxw4ad	474	5	infants	infant	NNS
cord-019001-ralxw4ad	474	6	with	with	IN
cord-019001-ralxw4ad	474	7	persistent	persistent	JJ
cord-019001-ralxw4ad	474	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	474	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	474	10	refractory	refractory	JJ
cord-019001-ralxw4ad	474	11	to	to	IN
cord-019001-ralxw4ad	474	12	inhaled	inhale	VBN
cord-019001-ralxw4ad	474	13	nitric	nitric	NN
cord-019001-ralxw4ad	474	14	oxide	oxide	NN
cord-019001-ralxw4ad	475	1	The	the	DT
cord-019001-ralxw4ad	475	2	use	use	NN
cord-019001-ralxw4ad	475	3	of	of	IN
cord-019001-ralxw4ad	475	4	inhaled	inhale	VBN
cord-019001-ralxw4ad	475	5	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	475	6	in	in	IN
cord-019001-ralxw4ad	475	7	nitroprusside	nitroprusside	JJ
cord-019001-ralxw4ad	475	8	-	-	HYPH
cord-019001-ralxw4ad	475	9	resistant	resistant	JJ
cord-019001-ralxw4ad	475	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	475	11	artery	artery	NN
cord-019001-ralxw4ad	475	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	476	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	476	2	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	476	3	(	(	-LRB-
cord-019001-ralxw4ad	476	4	PGI2	PGI2	NNP
cord-019001-ralxw4ad	476	5	)	)	-RRB-
cord-019001-ralxw4ad	476	6	is	be	VBZ
cord-019001-ralxw4ad	476	7	an	an	DT
cord-019001-ralxw4ad	476	8	effective	effective	JJ
cord-019001-ralxw4ad	476	9	addition	addition	NN
cord-019001-ralxw4ad	476	10	to	to	IN
cord-019001-ralxw4ad	476	11	the	the	DT
cord-019001-ralxw4ad	476	12	treatment	treatment	NN
cord-019001-ralxw4ad	476	13	of	of	IN
cord-019001-ralxw4ad	476	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	476	15	hypertension	hypertension	NN
cord-019001-ralxw4ad	476	16	and	and	CC
cord-019001-ralxw4ad	476	17	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	476	18	in	in	IN
cord-019001-ralxw4ad	476	19	the	the	DT
cord-019001-ralxw4ad	476	20	operating	operating	NN
cord-019001-ralxw4ad	476	21	room	room	NN
cord-019001-ralxw4ad	476	22	and	and	CC
cord-019001-ralxw4ad	476	23	intensive	intensive	JJ
cord-019001-ralxw4ad	476	24	care	care	NN
cord-019001-ralxw4ad	476	25	unit	unit	NN
cord-019001-ralxw4ad	476	26	Aerosolized	aerosolize	VBN
cord-019001-ralxw4ad	476	27	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	476	28	(	(	-LRB-
cord-019001-ralxw4ad	476	29	epoprostenol	epoprostenol	NNP
cord-019001-ralxw4ad	476	30	)	)	-RRB-
cord-019001-ralxw4ad	476	31	as	as	IN
cord-019001-ralxw4ad	476	32	an	an	DT
cord-019001-ralxw4ad	476	33	alternative	alternative	NN
cord-019001-ralxw4ad	476	34	to	to	IN
cord-019001-ralxw4ad	476	35	inhaled	inhale	VBN
cord-019001-ralxw4ad	476	36	nitric	nitric	JJ
cord-019001-ralxw4ad	476	37	oxide	oxide	NN
cord-019001-ralxw4ad	476	38	for	for	IN
cord-019001-ralxw4ad	476	39	patients	patient	NNS
cord-019001-ralxw4ad	476	40	with	with	IN
cord-019001-ralxw4ad	476	41	reperfusion	reperfusion	NN
cord-019001-ralxw4ad	476	42	injury	injury	NN
cord-019001-ralxw4ad	476	43	after	after	IN
cord-019001-ralxw4ad	476	44	lung	lung	NN
cord-019001-ralxw4ad	476	45	transplantation	transplantation	NN
cord-019001-ralxw4ad	476	46	Inhaled	inhale	VBD
cord-019001-ralxw4ad	476	47	aerosolized	aerosolize	VBN
cord-019001-ralxw4ad	476	48	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	476	49	and	and	CC
cord-019001-ralxw4ad	476	50	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	476	51	hypertension	hypertension	NN
cord-019001-ralxw4ad	476	52	during	during	IN
cord-019001-ralxw4ad	476	53	anesthesia	anesthesia	NN
cord-019001-ralxw4ad	476	54	for	for	IN
cord-019001-ralxw4ad	476	55	lung	lung	NN
cord-019001-ralxw4ad	476	56	transplantation	transplantation	NN
cord-019001-ralxw4ad	476	57	Effects	effect	NNS
cord-019001-ralxw4ad	476	58	of	of	IN
cord-019001-ralxw4ad	476	59	inhaled	inhale	VBN
cord-019001-ralxw4ad	476	60	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	476	61	analogue	analogue	NN
cord-019001-ralxw4ad	476	62	on	on	IN
cord-019001-ralxw4ad	476	63	chronic	chronic	JJ
cord-019001-ralxw4ad	476	64	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	476	65	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	476	66	hypertension	hypertension	NN
cord-019001-ralxw4ad	476	67	Dose	dose	NN
cord-019001-ralxw4ad	476	68	-	-	HYPH
cord-019001-ralxw4ad	476	69	response	response	NN
cord-019001-ralxw4ad	476	70	to	to	IN
cord-019001-ralxw4ad	476	71	inhaled	inhale	VBN
cord-019001-ralxw4ad	476	72	aerosolized	aerosolize	VBN
cord-019001-ralxw4ad	476	73	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	476	74	for	for	IN
cord-019001-ralxw4ad	476	75	hypoxemia	hypoxemia	NN
cord-019001-ralxw4ad	476	76	due	due	IN
cord-019001-ralxw4ad	476	77	to	to	IN
cord-019001-ralxw4ad	476	78	ARDS	ARDS	NNP
cord-019001-ralxw4ad	477	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	477	2	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	477	3	in	in	IN
cord-019001-ralxw4ad	477	4	the	the	DT
cord-019001-ralxw4ad	477	5	treatment	treatment	NN
cord-019001-ralxw4ad	477	6	of	of	IN
cord-019001-ralxw4ad	477	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	477	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	478	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	478	2	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	478	3	and	and	CC
cord-019001-ralxw4ad	478	4	iloprost	iloprost	NN
cord-019001-ralxw4ad	478	5	in	in	IN
cord-019001-ralxw4ad	478	6	severe	severe	JJ
cord-019001-ralxw4ad	478	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	478	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	478	9	secondary	secondary	JJ
cord-019001-ralxw4ad	478	10	to	to	IN
cord-019001-ralxw4ad	478	11	lung	lung	NN
cord-019001-ralxw4ad	478	12	fi	fi	NN
cord-019001-ralxw4ad	478	13	brosis	brosis	NN
cord-019001-ralxw4ad	478	14	Cyclic	cyclic	JJ
cord-019001-ralxw4ad	478	15	nucleotide	nucleotide	JJ
cord-019001-ralxw4ad	478	16	phosphodiesterases	phosphodiesterase	NNS
cord-019001-ralxw4ad	478	17	:	:	:
cord-019001-ralxw4ad	479	1	functional	functional	JJ
cord-019001-ralxw4ad	479	2	implications	implication	NNS
cord-019001-ralxw4ad	479	3	of	of	IN
cord-019001-ralxw4ad	480	1	multiple	multiple	JJ
cord-019001-ralxw4ad	480	2	isoforms	isoform	NNS
cord-019001-ralxw4ad	480	3	Milrinone	Milrinone	NNP
cord-019001-ralxw4ad	480	4	decreases	decrease	VBZ
cord-019001-ralxw4ad	480	5	both	both	DT
cord-019001-ralxw4ad	480	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	480	7	arterial	arterial	NN
cord-019001-ralxw4ad	480	8	and	and	CC
cord-019001-ralxw4ad	480	9	venous	venous	JJ
cord-019001-ralxw4ad	480	10	resistances	resistance	NNS
cord-019001-ralxw4ad	480	11	in	in	IN
cord-019001-ralxw4ad	480	12	the	the	DT
cord-019001-ralxw4ad	480	13	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	480	14	dog	dog	NN
cord-019001-ralxw4ad	480	15	Van	Van	NNP
cord-019001-ralxw4ad	480	16	Trigt	Trigt	NNP
cord-019001-ralxw4ad	480	17	P	p	NN
cord-019001-ralxw4ad	480	18	3rd	3rd	NN
cord-019001-ralxw4ad	480	19	.	.	.
cord-019001-ralxw4ad	481	1	Milrinone	Milrinone	NNP
cord-019001-ralxw4ad	481	2	improves	improve	VBZ
cord-019001-ralxw4ad	481	3	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	481	4	hemodynamics	hemodynamic	NNS
cord-019001-ralxw4ad	481	5	and	and	CC
cord-019001-ralxw4ad	481	6	right	right	JJ
cord-019001-ralxw4ad	481	7	ventricular	ventricular	JJ
cord-019001-ralxw4ad	481	8	function	function	NN
cord-019001-ralxw4ad	481	9	in	in	IN
cord-019001-ralxw4ad	481	10	chronic	chronic	JJ
cord-019001-ralxw4ad	481	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	481	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	481	13	Hemodynamic	Hemodynamic	NNP
cord-019001-ralxw4ad	481	14	and	and	CC
cord-019001-ralxw4ad	481	15	inotropic	inotropic	JJ
cord-019001-ralxw4ad	481	16	effects	effect	NNS
cord-019001-ralxw4ad	481	17	of	of	IN
cord-019001-ralxw4ad	481	18	milrinone	milrinone	NN
cord-019001-ralxw4ad	481	19	after	after	IN
cord-019001-ralxw4ad	481	20	heart	heart	NN
cord-019001-ralxw4ad	481	21	transplantation	transplantation	NN
cord-019001-ralxw4ad	481	22	in	in	IN
cord-019001-ralxw4ad	481	23	the	the	DT
cord-019001-ralxw4ad	481	24	setting	setting	NN
cord-019001-ralxw4ad	481	25	of	of	IN
cord-019001-ralxw4ad	481	26	recipient	recipient	JJ
cord-019001-ralxw4ad	481	27	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	481	28	hypertension	hypertension	NN
cord-019001-ralxw4ad	481	29	Milrinone	Milrinone	NNP
cord-019001-ralxw4ad	481	30	:	:	:
cord-019001-ralxw4ad	481	31	systemic	systemic	JJ
cord-019001-ralxw4ad	481	32	and	and	CC
cord-019001-ralxw4ad	481	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	481	34	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	481	35	effects	effect	NNS
cord-019001-ralxw4ad	481	36	in	in	IN
cord-019001-ralxw4ad	481	37	neonates	neonate	NNS
cord-019001-ralxw4ad	481	38	after	after	IN
cord-019001-ralxw4ad	481	39	cardiac	cardiac	JJ
cord-019001-ralxw4ad	481	40	surgery	surgery	NN
cord-019001-ralxw4ad	481	41	Effi	Effi	NNP
cord-019001-ralxw4ad	481	42	cacy	cacy	NN
cord-019001-ralxw4ad	481	43	and	and	CC
cord-019001-ralxw4ad	481	44	safety	safety	NN
cord-019001-ralxw4ad	481	45	of	of	IN
cord-019001-ralxw4ad	481	46	milrinone	milrinone	NNP
cord-019001-ralxw4ad	481	47	in	in	IN
cord-019001-ralxw4ad	481	48	preventing	prevent	VBG
cord-019001-ralxw4ad	481	49	low	low	JJ
cord-019001-ralxw4ad	481	50	cardiac	cardiac	JJ
cord-019001-ralxw4ad	481	51	output	output	NN
cord-019001-ralxw4ad	481	52	syndrome	syndrome	NN
cord-019001-ralxw4ad	481	53	in	in	IN
cord-019001-ralxw4ad	481	54	infants	infant	NNS
cord-019001-ralxw4ad	481	55	and	and	CC
cord-019001-ralxw4ad	481	56	children	child	NNS
cord-019001-ralxw4ad	481	57	after	after	IN
cord-019001-ralxw4ad	481	58	corrective	corrective	JJ
cord-019001-ralxw4ad	481	59	surgery	surgery	NN
cord-019001-ralxw4ad	481	60	for	for	IN
cord-019001-ralxw4ad	481	61	congenital	congenital	JJ
cord-019001-ralxw4ad	481	62	heart	heart	NN
cord-019001-ralxw4ad	481	63	disease	disease	NN
cord-019001-ralxw4ad	481	64	Sildenafi	Sildenafi	NNP
cord-019001-ralxw4ad	481	65	l	l	NNP
cord-019001-ralxw4ad	481	66	for	for	IN
cord-019001-ralxw4ad	481	67	primary	primary	JJ
cord-019001-ralxw4ad	481	68	and	and	CC
cord-019001-ralxw4ad	481	69	secondary	secondary	JJ
cord-019001-ralxw4ad	481	70	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	481	71	hypertension	hypertension	NN
cord-019001-ralxw4ad	482	1	Benefi	Benefi	NNP
cord-019001-ralxw4ad	482	2	cial	cial	JJ
cord-019001-ralxw4ad	482	3	effect	effect	NN
cord-019001-ralxw4ad	482	4	of	of	IN
cord-019001-ralxw4ad	482	5	oral	oral	JJ
cord-019001-ralxw4ad	482	6	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	482	7	l	l	NNP
cord-019001-ralxw4ad	482	8	therapy	therapy	NN
cord-019001-ralxw4ad	482	9	on	on	IN
cord-019001-ralxw4ad	482	10	childhood	childhood	NN
cord-019001-ralxw4ad	482	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	482	12	arterial	arterial	JJ
cord-019001-ralxw4ad	482	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	482	14	:	:	:
cord-019001-ralxw4ad	482	15	twelve	twelve	CD
cord-019001-ralxw4ad	482	16	-	-	HYPH
cord-019001-ralxw4ad	482	17	month	month	NN
cord-019001-ralxw4ad	482	18	clinical	clinical	JJ
cord-019001-ralxw4ad	482	19	trial	trial	NN
cord-019001-ralxw4ad	482	20	of	of	IN
cord-019001-ralxw4ad	482	21	a	a	DT
cord-019001-ralxw4ad	482	22	single	single	JJ
cord-019001-ralxw4ad	482	23	-	-	HYPH
cord-019001-ralxw4ad	482	24	drug	drug	NN
cord-019001-ralxw4ad	482	25	,	,	,
cord-019001-ralxw4ad	482	26	open	open	JJ
cord-019001-ralxw4ad	482	27	-	-	HYPH
cord-019001-ralxw4ad	482	28	label	label	NN
cord-019001-ralxw4ad	482	29	,	,	,
cord-019001-ralxw4ad	482	30	pilot	pilot	NN
cord-019001-ralxw4ad	482	31	study	study	NN
cord-019001-ralxw4ad	482	32	Interaction	Interaction	NNP
cord-019001-ralxw4ad	482	33	between	between	IN
cord-019001-ralxw4ad	482	34	inhaled	inhale	VBN
cord-019001-ralxw4ad	482	35	nitric	nitric	JJ
cord-019001-ralxw4ad	482	36	oxide	oxide	NN
cord-019001-ralxw4ad	482	37	and	and	CC
cord-019001-ralxw4ad	482	38	intravenous	intravenous	JJ
cord-019001-ralxw4ad	482	39	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	482	40	l	l	NNP
cord-019001-ralxw4ad	482	41	in	in	IN
cord-019001-ralxw4ad	482	42	a	a	DT
cord-019001-ralxw4ad	482	43	porcine	porcine	JJ
cord-019001-ralxw4ad	482	44	model	model	NN
cord-019001-ralxw4ad	482	45	of	of	IN
cord-019001-ralxw4ad	482	46	meconium	meconium	NN
cord-019001-ralxw4ad	482	47	aspiration	aspiration	NN
cord-019001-ralxw4ad	482	48	syndrome	syndrome	NN
cord-019001-ralxw4ad	482	49	Intravenous	Intravenous	NNP
cord-019001-ralxw4ad	482	50	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	482	51	l	l	NN
cord-019001-ralxw4ad	482	52	and	and	CC
cord-019001-ralxw4ad	482	53	inhaled	inhale	VBD
cord-019001-ralxw4ad	482	54	nitric	nitric	NN
cord-019001-ralxw4ad	482	55	oxide	oxide	NN
cord-019001-ralxw4ad	482	56	:	:	:
cord-019001-ralxw4ad	482	57	a	a	DT
cord-019001-ralxw4ad	482	58	randomised	randomised	JJ
cord-019001-ralxw4ad	482	59	trial	trial	NN
cord-019001-ralxw4ad	482	60	in	in	IN
cord-019001-ralxw4ad	482	61	infants	infant	NNS
cord-019001-ralxw4ad	482	62	after	after	IN
cord-019001-ralxw4ad	482	63	cardiac	cardiac	JJ
cord-019001-ralxw4ad	482	64	surgery	surgery	NN
cord-019001-ralxw4ad	482	65	Effects	effect	NNS
cord-019001-ralxw4ad	482	66	of	of	IN
cord-019001-ralxw4ad	482	67	the	the	DT
cord-019001-ralxw4ad	482	68	dual	dual	JJ
cord-019001-ralxw4ad	482	69	endothelin	endothelin	JJ
cord-019001-ralxw4ad	482	70	-	-	HYPH
cord-019001-ralxw4ad	482	71	receptor	receptor	NN
cord-019001-ralxw4ad	482	72	antagonist	antagonist	NN
cord-019001-ralxw4ad	482	73	bosentan	bosentan	NNP
cord-019001-ralxw4ad	482	74	in	in	IN
cord-019001-ralxw4ad	482	75	patients	patient	NNS
cord-019001-ralxw4ad	482	76	with	with	IN
cord-019001-ralxw4ad	482	77	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	482	78	hypertension	hypertension	NN
cord-019001-ralxw4ad	482	79	:	:	:
cord-019001-ralxw4ad	482	80	a	a	DT
cord-019001-ralxw4ad	482	81	randomised	randomised	JJ
cord-019001-ralxw4ad	482	82	placebocontrolled	placebocontrolled	JJ
cord-019001-ralxw4ad	482	83	study	study	NN
cord-019001-ralxw4ad	482	84	Bosentan	Bosentan	NNP
cord-019001-ralxw4ad	482	85	therapy	therapy	NN
cord-019001-ralxw4ad	482	86	for	for	IN
cord-019001-ralxw4ad	482	87	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	482	88	arterial	arterial	JJ
cord-019001-ralxw4ad	482	89	hypertension	hypertension	NN
cord-019001-ralxw4ad	482	90	Surgical	surgical	JJ
cord-019001-ralxw4ad	482	91	implications	implication	NNS
cord-019001-ralxw4ad	482	92	of	of	IN
cord-019001-ralxw4ad	482	93	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	482	94	hypertension	hypertension	NN
cord-019001-ralxw4ad	482	95	in	in	IN
cord-019001-ralxw4ad	482	96	congenital	congenital	JJ
cord-019001-ralxw4ad	482	97	heart	heart	NN
cord-019001-ralxw4ad	482	98	disease	disease	NN
cord-019001-ralxw4ad	483	1	The	the	DT
cord-019001-ralxw4ad	483	2	effects	effect	NNS
cord-019001-ralxw4ad	483	3	of	of	IN
cord-019001-ralxw4ad	483	4	dopamine	dopamine	NN
cord-019001-ralxw4ad	483	5	and	and	CC
cord-019001-ralxw4ad	483	6	isoproterenol	isoproterenol	NN
cord-019001-ralxw4ad	483	7	on	on	IN
cord-019001-ralxw4ad	483	8	the	the	DT
cord-019001-ralxw4ad	483	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	483	10	circulation	circulation	NN
cord-019001-ralxw4ad	483	11	Acute	acute	JJ
cord-019001-ralxw4ad	483	12	circulatory	circulatory	JJ
cord-019001-ralxw4ad	483	13	effects	effect	NNS
cord-019001-ralxw4ad	483	14	of	of	IN
cord-019001-ralxw4ad	483	15	dopamine	dopamine	NN
cord-019001-ralxw4ad	483	16	in	in	IN
cord-019001-ralxw4ad	483	17	patients	patient	NNS
cord-019001-ralxw4ad	483	18	with	with	IN
cord-019001-ralxw4ad	483	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	483	20	hypertension	hypertension	NN
cord-019001-ralxw4ad	483	21	Dobutamine	Dobutamine	NNP
cord-019001-ralxw4ad	483	22	pharmacokinetics	pharmacokinetic	NNS
cord-019001-ralxw4ad	483	23	and	and	CC
cord-019001-ralxw4ad	483	24	cardiovascular	cardiovascular	JJ
cord-019001-ralxw4ad	483	25	responses	response	NNS
cord-019001-ralxw4ad	483	26	in	in	IN
cord-019001-ralxw4ad	483	27	critically	critically	RB
cord-019001-ralxw4ad	483	28	ill	ill	JJ
cord-019001-ralxw4ad	483	29	neonates	neonate	NNS
cord-019001-ralxw4ad	483	30	Dobutamine	Dobutamine	NNP
cord-019001-ralxw4ad	483	31	:	:	:
cord-019001-ralxw4ad	483	32	a	a	DT
cord-019001-ralxw4ad	483	33	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	483	34	evaluation	evaluation	NN
cord-019001-ralxw4ad	483	35	in	in	IN
cord-019001-ralxw4ad	483	36	children	child	NNS
cord-019001-ralxw4ad	483	37	with	with	IN
cord-019001-ralxw4ad	483	38	shock	shock	NN
cord-019001-ralxw4ad	483	39	Effects	effect	NNS
cord-019001-ralxw4ad	483	40	of	of	IN
cord-019001-ralxw4ad	483	41	vasoactive	vasoactive	JJ
cord-019001-ralxw4ad	483	42	drugs	drug	NNS
cord-019001-ralxw4ad	483	43	on	on	IN
cord-019001-ralxw4ad	483	44	thromboxane	thromboxane	NNP
cord-019001-ralxw4ad	483	45	A2	A2	NNP
cord-019001-ralxw4ad	483	46	mimetic	mimetic	NN
cord-019001-ralxw4ad	483	47	-	-	HYPH
cord-019001-ralxw4ad	483	48	induced	induce	VBN
cord-019001-ralxw4ad	483	49	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	483	50	hypertension	hypertension	NN
cord-019001-ralxw4ad	483	51	in	in	IN
cord-019001-ralxw4ad	483	52	newborn	newborn	JJ
cord-019001-ralxw4ad	483	53	lambs	lamb	NNS
cord-019001-ralxw4ad	483	54	Factors	factor	NNS
cord-019001-ralxw4ad	483	55	that	that	IN
cord-019001-ralxw4ad	483	56	infl	infl	XX
cord-019001-ralxw4ad	483	57	uence	uence	NNP
cord-019001-ralxw4ad	483	58	the	the	DT
cord-019001-ralxw4ad	483	59	outcome	outcome	NN
cord-019001-ralxw4ad	483	60	of	of	IN
cord-019001-ralxw4ad	483	61	primary	primary	JJ
cord-019001-ralxw4ad	483	62	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	483	63	hypertension	hypertension	NN
cord-019001-ralxw4ad	483	64	Atrial	Atrial	NNP
cord-019001-ralxw4ad	483	65	septostomy	septostomy	NN
cord-019001-ralxw4ad	483	66	as	as	IN
cord-019001-ralxw4ad	483	67	palliative	palliative	JJ
cord-019001-ralxw4ad	483	68	therapy	therapy	NN
cord-019001-ralxw4ad	483	69	for	for	IN
cord-019001-ralxw4ad	483	70	refractory	refractory	JJ
cord-019001-ralxw4ad	483	71	primary	primary	JJ
cord-019001-ralxw4ad	483	72	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	483	73	hypertension	hypertension	NN
cord-019001-ralxw4ad	483	74	Double	double	JJ
cord-019001-ralxw4ad	483	75	balloon	balloon	NN
cord-019001-ralxw4ad	483	76	technique	technique	NN
cord-019001-ralxw4ad	483	77	for	for	IN
cord-019001-ralxw4ad	483	78	dilation	dilation	NN
cord-019001-ralxw4ad	483	79	of	of	IN
cord-019001-ralxw4ad	483	80	valvular	valvular	JJ
cord-019001-ralxw4ad	483	81	or	or	CC
cord-019001-ralxw4ad	483	82	vessel	vessel	NN
cord-019001-ralxw4ad	483	83	stenosis	stenosis	NN
cord-019001-ralxw4ad	483	84	in	in	IN
cord-019001-ralxw4ad	483	85	congenital	congenital	JJ
cord-019001-ralxw4ad	483	86	and	and	CC
cord-019001-ralxw4ad	483	87	acquired	acquire	VBD
cord-019001-ralxw4ad	483	88	heart	heart	NN
cord-019001-ralxw4ad	483	89	disease	disease	NN
cord-019001-ralxw4ad	484	1	Successful	successful	JJ
cord-019001-ralxw4ad	484	2	palliation	palliation	NN
cord-019001-ralxw4ad	484	3	of	of	IN
cord-019001-ralxw4ad	484	4	primary	primary	JJ
cord-019001-ralxw4ad	484	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	484	6	hypertension	hypertension	NN
cord-019001-ralxw4ad	484	7	by	by	IN
cord-019001-ralxw4ad	484	8	atrial	atrial	JJ
cord-019001-ralxw4ad	484	9	septostomy	septostomy	NN
cord-019001-ralxw4ad	484	10	Blade	Blade	NNP
cord-019001-ralxw4ad	484	11	balloon	balloon	NN
cord-019001-ralxw4ad	484	12	atrial	atrial	JJ
cord-019001-ralxw4ad	484	13	septostomy	septostomy	NN
cord-019001-ralxw4ad	484	14	in	in	IN
cord-019001-ralxw4ad	484	15	patients	patient	NNS
cord-019001-ralxw4ad	484	16	with	with	IN
cord-019001-ralxw4ad	484	17	severe	severe	JJ
cord-019001-ralxw4ad	484	18	primary	primary	JJ
cord-019001-ralxw4ad	484	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	484	20	hypertension	hypertension	NN
cord-019001-ralxw4ad	484	21	Graded	grade	VBN
cord-019001-ralxw4ad	484	22	balloon	balloon	NN
cord-019001-ralxw4ad	484	23	dilation	dilation	NN
cord-019001-ralxw4ad	484	24	atrial	atrial	JJ
cord-019001-ralxw4ad	484	25	septostomy	septostomy	NN
cord-019001-ralxw4ad	484	26	in	in	IN
cord-019001-ralxw4ad	484	27	severe	severe	JJ
cord-019001-ralxw4ad	484	28	primary	primary	JJ
cord-019001-ralxw4ad	484	29	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	484	30	hypertension	hypertension	NN
cord-019001-ralxw4ad	484	31	.	.	.
cord-019001-ralxw4ad	485	1	A	a	DT
cord-019001-ralxw4ad	485	2	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	485	3	alternative	alternative	NN
cord-019001-ralxw4ad	485	4	for	for	IN
cord-019001-ralxw4ad	485	5	patients	patient	NNS
cord-019001-ralxw4ad	485	6	nonresponsive	nonresponsive	JJ
cord-019001-ralxw4ad	485	7	to	to	IN
cord-019001-ralxw4ad	485	8	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	485	9	treatment	treatment	NN
cord-019001-ralxw4ad	485	10	Long	long	JJ
cord-019001-ralxw4ad	485	11	-	-	HYPH
cord-019001-ralxw4ad	485	12	term	term	NN
cord-019001-ralxw4ad	485	13	treatment	treatment	NN
cord-019001-ralxw4ad	485	14	of	of	IN
cord-019001-ralxw4ad	485	15	primary	primary	JJ
cord-019001-ralxw4ad	485	16	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	485	17	hypertension	hypertension	NN
cord-019001-ralxw4ad	485	18	with	with	IN
cord-019001-ralxw4ad	485	19	continuous	continuous	JJ
cord-019001-ralxw4ad	485	20	intravenous	intravenous	JJ
cord-019001-ralxw4ad	485	21	epoprostenol	epoprostenol	NN
cord-019001-ralxw4ad	486	1	(	(	-LRB-
cord-019001-ralxw4ad	486	2	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	486	3	)	)	-RRB-
cord-019001-ralxw4ad	486	4	Survival	Survival	NNP
cord-019001-ralxw4ad	486	5	in	in	IN
cord-019001-ralxw4ad	486	6	primary	primary	JJ
cord-019001-ralxw4ad	486	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	486	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	486	9	with	with	IN
cord-019001-ralxw4ad	486	10	long	long	JJ
cord-019001-ralxw4ad	486	11	-	-	HYPH
cord-019001-ralxw4ad	486	12	term	term	NN
cord-019001-ralxw4ad	486	13	continuous	continuous	JJ
cord-019001-ralxw4ad	486	14	intravenous	intravenous	JJ
cord-019001-ralxw4ad	486	15	prostacyclin	prostacyclin	NN
cord-019001-ralxw4ad	487	1	A	a	DT
cord-019001-ralxw4ad	487	2	comparison	comparison	NN
cord-019001-ralxw4ad	487	3	of	of	IN
cord-019001-ralxw4ad	487	4	continuous	continuous	JJ
cord-019001-ralxw4ad	487	5	intravenous	intravenous	JJ
cord-019001-ralxw4ad	487	6	epoprostenol	epoprostenol	NN
cord-019001-ralxw4ad	487	7	(	(	-LRB-
cord-019001-ralxw4ad	487	8	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	487	9	)	)	-RRB-
cord-019001-ralxw4ad	487	10	with	with	IN
cord-019001-ralxw4ad	487	11	conventional	conventional	JJ
cord-019001-ralxw4ad	487	12	therapy	therapy	NN
cord-019001-ralxw4ad	487	13	for	for	IN
cord-019001-ralxw4ad	487	14	primary	primary	JJ
cord-019001-ralxw4ad	487	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	487	16	hypertension	hypertension	NN
cord-019001-ralxw4ad	487	17	.	.	.
cord-019001-ralxw4ad	488	1	The	the	DT
cord-019001-ralxw4ad	488	2	Primary	Primary	NNP
cord-019001-ralxw4ad	488	3	Pulmonary	Pulmonary	NNP
cord-019001-ralxw4ad	488	4	Hypertension	Hypertension	NNP
cord-019001-ralxw4ad	488	5	Study	Study	NNP
cord-019001-ralxw4ad	488	6	Group	Group	NNP
cord-019001-ralxw4ad	488	7	Primary	primary	JJ
cord-019001-ralxw4ad	488	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	488	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	488	10	:	:	:
cord-019001-ralxw4ad	488	11	improved	improve	VBN
cord-019001-ralxw4ad	488	12	long	long	JJ
cord-019001-ralxw4ad	488	13	-	-	HYPH
cord-019001-ralxw4ad	488	14	term	term	NN
cord-019001-ralxw4ad	488	15	effects	effect	NNS
cord-019001-ralxw4ad	488	16	and	and	CC
cord-019001-ralxw4ad	488	17	survival	survival	NN
cord-019001-ralxw4ad	488	18	with	with	IN
cord-019001-ralxw4ad	488	19	continuous	continuous	JJ
cord-019001-ralxw4ad	488	20	intravenous	intravenous	JJ
cord-019001-ralxw4ad	488	21	epoprostenol	epoprostenol	NN
cord-019001-ralxw4ad	488	22	infusion	infusion	NN
cord-019001-ralxw4ad	488	23	Reduction	reduction	NN
cord-019001-ralxw4ad	488	24	in	in	IN
cord-019001-ralxw4ad	488	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	488	26	vascular	vascular	JJ
cord-019001-ralxw4ad	488	27	resistance	resistance	NN
cord-019001-ralxw4ad	488	28	with	with	IN
cord-019001-ralxw4ad	488	29	long	long	JJ
cord-019001-ralxw4ad	488	30	-	-	HYPH
cord-019001-ralxw4ad	488	31	term	term	NN
cord-019001-ralxw4ad	488	32	epoprostenol	epoprostenol	NN
cord-019001-ralxw4ad	488	33	(	(	-LRB-
cord-019001-ralxw4ad	488	34	prostacyclin	prostacyclin	NNP
cord-019001-ralxw4ad	488	35	)	)	-RRB-
cord-019001-ralxw4ad	488	36	therapy	therapy	NN
cord-019001-ralxw4ad	488	37	in	in	IN
cord-019001-ralxw4ad	488	38	primary	primary	JJ
cord-019001-ralxw4ad	488	39	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	488	40	hypertension	hypertension	NN
cord-019001-ralxw4ad	488	41	Vasodilator	Vasodilator	NNP
cord-019001-ralxw4ad	488	42	therapy	therapy	NN
cord-019001-ralxw4ad	488	43	for	for	IN
cord-019001-ralxw4ad	488	44	primary	primary	JJ
cord-019001-ralxw4ad	488	45	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	488	46	hypertension	hypertension	NN
cord-019001-ralxw4ad	488	47	in	in	IN
cord-019001-ralxw4ad	488	48	children	child	NNS
cord-019001-ralxw4ad	489	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	489	2	arterial	arterial	JJ
cord-019001-ralxw4ad	489	3	hypertension	hypertension	NN
cord-019001-ralxw4ad	489	4	in	in	IN
cord-019001-ralxw4ad	489	5	children	child	NNS
cord-019001-ralxw4ad	490	1	Survival	survival	NN
cord-019001-ralxw4ad	490	2	with	with	IN
cord-019001-ralxw4ad	490	3	fi	fi	NNP
cord-019001-ralxw4ad	490	4	rst	rst	JJ
cord-019001-ralxw4ad	490	5	-	-	HYPH
cord-019001-ralxw4ad	490	6	line	line	NN
cord-019001-ralxw4ad	490	7	bosentan	bosentan	NNP
cord-019001-ralxw4ad	490	8	in	in	IN
cord-019001-ralxw4ad	490	9	patients	patient	NNS
cord-019001-ralxw4ad	490	10	with	with	IN
cord-019001-ralxw4ad	490	11	primary	primary	JJ
cord-019001-ralxw4ad	490	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	490	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	490	14	Treatment	treatment	NN
cord-019001-ralxw4ad	490	15	of	of	IN
cord-019001-ralxw4ad	490	16	rebound	rebound	NN
cord-019001-ralxw4ad	490	17	and	and	CC
cord-019001-ralxw4ad	490	18	chronic	chronic	JJ
cord-019001-ralxw4ad	490	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	490	20	hypertension	hypertension	NN
cord-019001-ralxw4ad	490	21	with	with	IN
cord-019001-ralxw4ad	490	22	oral	oral	JJ
cord-019001-ralxw4ad	490	23	sildenafi	sildenafi	NNP
cord-019001-ralxw4ad	490	24	l	l	NNP
cord-019001-ralxw4ad	490	25	in	in	IN
cord-019001-ralxw4ad	490	26	an	an	DT
cord-019001-ralxw4ad	490	27	infant	infant	NN
cord-019001-ralxw4ad	490	28	with	with	IN
cord-019001-ralxw4ad	490	29	congenital	congenital	JJ
cord-019001-ralxw4ad	490	30	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	490	31	hernia	hernia	NN
cord-019001-ralxw4ad	490	32	Ventilatory	ventilatory	JJ
cord-019001-ralxw4ad	490	33	predictors	predictor	NNS
cord-019001-ralxw4ad	490	34	of	of	IN
cord-019001-ralxw4ad	490	35	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	490	36	hypoplasia	hypoplasia	NN
cord-019001-ralxw4ad	490	37	in	in	IN
cord-019001-ralxw4ad	490	38	congenital	congenital	JJ
cord-019001-ralxw4ad	490	39	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	490	40	hernia	hernia	NN
cord-019001-ralxw4ad	490	41	,	,	,
cord-019001-ralxw4ad	490	42	confi	confi	NNP
cord-019001-ralxw4ad	490	43	rmed	rme	VBN
cord-019001-ralxw4ad	490	44	by	by	IN
cord-019001-ralxw4ad	490	45	morphologic	morphologic	JJ
cord-019001-ralxw4ad	490	46	assessment	assessment	NN
cord-019001-ralxw4ad	491	1	Unsuspected	unsuspected	JJ
cord-019001-ralxw4ad	491	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	491	3	vascular	vascular	JJ
cord-019001-ralxw4ad	491	4	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	491	5	associated	associate	VBN
cord-019001-ralxw4ad	491	6	with	with	IN
cord-019001-ralxw4ad	491	7	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	491	8	hernia	hernia	NN
cord-019001-ralxw4ad	491	9	Morphologic	morphologic	JJ
cord-019001-ralxw4ad	491	10	analysis	analysis	NN
cord-019001-ralxw4ad	491	11	of	of	IN
cord-019001-ralxw4ad	491	12	the	the	DT
cord-019001-ralxw4ad	491	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	491	14	vascular	vascular	JJ
cord-019001-ralxw4ad	491	15	bed	bed	NN
cord-019001-ralxw4ad	491	16	in	in	IN
cord-019001-ralxw4ad	491	17	congenital	congenital	JJ
cord-019001-ralxw4ad	491	18	left	left	JJ
cord-019001-ralxw4ad	491	19	-	-	HYPH
cord-019001-ralxw4ad	491	20	sided	sided	JJ
cord-019001-ralxw4ad	491	21	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	491	22	hernia	hernia	NN
cord-019001-ralxw4ad	491	23	Mortality	mortality	NN
cord-019001-ralxw4ad	491	24	from	from	IN
cord-019001-ralxw4ad	491	25	neonatal	neonatal	JJ
cord-019001-ralxw4ad	491	26	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	491	27	hernia	hernia	NN
cord-019001-ralxw4ad	491	28	Vasodilator	Vasodilator	NNP
cord-019001-ralxw4ad	491	29	response	response	NN
cord-019001-ralxw4ad	491	30	and	and	CC
cord-019001-ralxw4ad	491	31	prediction	prediction	NN
cord-019001-ralxw4ad	491	32	of	of	IN
cord-019001-ralxw4ad	491	33	survival	survival	NN
cord-019001-ralxw4ad	491	34	in	in	IN
cord-019001-ralxw4ad	491	35	congenital	congenital	JJ
cord-019001-ralxw4ad	491	36	diaphragmatic	diaphragmatic	JJ
cord-019001-ralxw4ad	491	37	hernia	hernia	NN
cord-019001-ralxw4ad	491	38	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	491	39	hypertension	hypertension	NN
cord-019001-ralxw4ad	491	40	in	in	IN
cord-019001-ralxw4ad	491	41	the	the	DT
cord-019001-ralxw4ad	491	42	perinatal	perinatal	JJ
cord-019001-ralxw4ad	491	43	aspiration	aspiration	NN
cord-019001-ralxw4ad	491	44	syndromes	syndrome	NNS
cord-019001-ralxw4ad	492	1	beta	beta	JJ
cord-019001-ralxw4ad	492	2	-	-	HYPH
cord-019001-ralxw4ad	492	3	hemolytic	hemolytic	JJ
cord-019001-ralxw4ad	492	4	streptococcal	streptococcal	JJ
cord-019001-ralxw4ad	492	5	infection	infection	NN
cord-019001-ralxw4ad	492	6	appearing	appear	VBG
cord-019001-ralxw4ad	492	7	as	as	IN
cord-019001-ralxw4ad	492	8	persistent	persistent	JJ
cord-019001-ralxw4ad	492	9	fetal	fetal	JJ
cord-019001-ralxw4ad	492	10	circulation	circulation	NN
cord-019001-ralxw4ad	492	11	Persistent	persistent	JJ
cord-019001-ralxw4ad	492	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	492	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	492	14	:	:	:
cord-019001-ralxw4ad	492	15	assessment	assessment	NN
cord-019001-ralxw4ad	492	16	of	of	IN
cord-019001-ralxw4ad	492	17	perinatal	perinatal	JJ
cord-019001-ralxw4ad	492	18	risk	risk	NN
cord-019001-ralxw4ad	492	19	factors	factor	NNS
cord-019001-ralxw4ad	493	1	Umbilical	umbilical	JJ
cord-019001-ralxw4ad	493	2	cord	cord	NN
cord-019001-ralxw4ad	493	3	compression	compression	NN
cord-019001-ralxw4ad	493	4	produces	produce	VBZ
cord-019001-ralxw4ad	493	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	493	6	hypertension	hypertension	NN
cord-019001-ralxw4ad	493	7	in	in	IN
cord-019001-ralxw4ad	493	8	newborn	newborn	JJ
cord-019001-ralxw4ad	493	9	lambs	lamb	NNS
cord-019001-ralxw4ad	493	10	:	:	:
cord-019001-ralxw4ad	493	11	a	a	DT
cord-019001-ralxw4ad	493	12	model	model	NN
cord-019001-ralxw4ad	493	13	to	to	TO
cord-019001-ralxw4ad	493	14	study	study	VB
cord-019001-ralxw4ad	493	15	the	the	DT
cord-019001-ralxw4ad	493	16	pathophysiology	pathophysiology	NN
cord-019001-ralxw4ad	493	17	of	of	IN
cord-019001-ralxw4ad	493	18	persistent	persistent	JJ
cord-019001-ralxw4ad	493	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	493	20	hypertension	hypertension	NN
cord-019001-ralxw4ad	493	21	in	in	IN
cord-019001-ralxw4ad	493	22	the	the	DT
cord-019001-ralxw4ad	493	23	newborn	newborn	JJ
cord-019001-ralxw4ad	493	24	Hemodynamic	Hemodynamic	NNP
cord-019001-ralxw4ad	493	25	,	,	,
cord-019001-ralxw4ad	493	26	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	493	27	vascular	vascular	JJ
cord-019001-ralxw4ad	493	28	,	,	,
cord-019001-ralxw4ad	493	29	and	and	CC
cord-019001-ralxw4ad	493	30	myocardial	myocardial	JJ
cord-019001-ralxw4ad	493	31	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	493	32	secondary	secondary	JJ
cord-019001-ralxw4ad	493	33	to	to	IN
cord-019001-ralxw4ad	493	34	pharmacologic	pharmacologic	JJ
cord-019001-ralxw4ad	493	35	constriction	constriction	NN
cord-019001-ralxw4ad	493	36	of	of	IN
cord-019001-ralxw4ad	493	37	the	the	DT
cord-019001-ralxw4ad	493	38	fetal	fetal	JJ
cord-019001-ralxw4ad	493	39	ductus	ductus	NN
cord-019001-ralxw4ad	493	40	arteriosus	arteriosus	NN
cord-019001-ralxw4ad	493	41	.	.	.
cord-019001-ralxw4ad	494	1	A	a	DT
cord-019001-ralxw4ad	494	2	possible	possible	JJ
cord-019001-ralxw4ad	494	3	mechanism	mechanism	NN
cord-019001-ralxw4ad	494	4	for	for	IN
cord-019001-ralxw4ad	494	5	persistent	persistent	JJ
cord-019001-ralxw4ad	494	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	494	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	494	8	and	and	CC
cord-019001-ralxw4ad	494	9	transient	transient	JJ
cord-019001-ralxw4ad	494	10	tricuspid	tricuspid	JJ
cord-019001-ralxw4ad	494	11	insufficiency	insufficiency	NN
cord-019001-ralxw4ad	494	12	in	in	IN
cord-019001-ralxw4ad	494	13	the	the	DT
cord-019001-ralxw4ad	494	14	newborn	newborn	JJ
cord-019001-ralxw4ad	494	15	infant	infant	NN
cord-019001-ralxw4ad	495	1	Ligating	Ligating	NNP
cord-019001-ralxw4ad	496	1	the	the	DT
cord-019001-ralxw4ad	496	2	ductus	ductus	NN
cord-019001-ralxw4ad	496	3	arteriosus	arteriosus	NN
cord-019001-ralxw4ad	496	4	before	before	IN
cord-019001-ralxw4ad	496	5	birth	birth	NN
cord-019001-ralxw4ad	496	6	causes	cause	VBZ
cord-019001-ralxw4ad	496	7	persistent	persistent	JJ
cord-019001-ralxw4ad	496	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	496	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	496	10	in	in	IN
cord-019001-ralxw4ad	496	11	the	the	DT
cord-019001-ralxw4ad	496	12	newborn	newborn	JJ
cord-019001-ralxw4ad	496	13	lamb	lamb	NN
cord-019001-ralxw4ad	497	1	Ligating	ligate	VBG
cord-019001-ralxw4ad	497	2	the	the	DT
cord-019001-ralxw4ad	497	3	ductus	ductus	NN
cord-019001-ralxw4ad	497	4	arteriosus	arteriosus	NN
cord-019001-ralxw4ad	497	5	before	before	IN
cord-019001-ralxw4ad	497	6	birth	birth	NN
cord-019001-ralxw4ad	497	7	remodels	remodel	NNS
cord-019001-ralxw4ad	498	1	the	the	DT
cord-019001-ralxw4ad	498	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	498	3	vasculature	vasculature	NN
cord-019001-ralxw4ad	498	4	of	of	IN
cord-019001-ralxw4ad	498	5	the	the	DT
cord-019001-ralxw4ad	498	6	lamb	lamb	NN
cord-019001-ralxw4ad	498	7	Chronic	Chronic	NNP
cord-019001-ralxw4ad	498	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	498	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	498	10	in	in	IN
cord-019001-ralxw4ad	498	11	utero	utero	NN
cord-019001-ralxw4ad	498	12	impairs	impair	VBZ
cord-019001-ralxw4ad	498	13	endothelium	endothelium	NN
cord-019001-ralxw4ad	498	14	-	-	HYPH
cord-019001-ralxw4ad	498	15	dependent	dependent	JJ
cord-019001-ralxw4ad	498	16	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	499	1	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	499	2	endothelial	endothelial	NN
cord-019001-ralxw4ad	500	1	NO	no	DT
cord-019001-ralxw4ad	500	2	synthase	synthase	NN
cord-019001-ralxw4ad	500	3	gene	gene	NN
cord-019001-ralxw4ad	500	4	expression	expression	NN
cord-019001-ralxw4ad	500	5	is	be	VBZ
cord-019001-ralxw4ad	500	6	decreased	decrease	VBN
cord-019001-ralxw4ad	500	7	in	in	IN
cord-019001-ralxw4ad	500	8	fetal	fetal	JJ
cord-019001-ralxw4ad	500	9	lambs	lamb	NNS
cord-019001-ralxw4ad	500	10	with	with	IN
cord-019001-ralxw4ad	500	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	500	12	hypertension	hypertension	NN
cord-019001-ralxw4ad	501	1	Possible	possible	JJ
cord-019001-ralxw4ad	501	2	association	association	NN
cord-019001-ralxw4ad	501	3	between	between	IN
cord-019001-ralxw4ad	501	4	maternal	maternal	JJ
cord-019001-ralxw4ad	501	5	indomethacin	indomethacin	NN
cord-019001-ralxw4ad	501	6	therapy	therapy	NN
cord-019001-ralxw4ad	501	7	and	and	CC
cord-019001-ralxw4ad	501	8	primary	primary	JJ
cord-019001-ralxw4ad	501	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	501	10	hypertension	hypertension	NN
cord-019001-ralxw4ad	501	11	of	of	IN
cord-019001-ralxw4ad	501	12	the	the	DT
cord-019001-ralxw4ad	501	13	newborn	newborn	JJ
cord-019001-ralxw4ad	501	14	Morphologic	morphologic	JJ
cord-019001-ralxw4ad	501	15	analysis	analysis	NN
cord-019001-ralxw4ad	501	16	of	of	IN
cord-019001-ralxw4ad	501	17	the	the	DT
cord-019001-ralxw4ad	501	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	501	19	vascular	vascular	JJ
cord-019001-ralxw4ad	501	20	bed	bed	NN
cord-019001-ralxw4ad	501	21	in	in	IN
cord-019001-ralxw4ad	501	22	infants	infant	NNS
cord-019001-ralxw4ad	501	23	exposed	expose	VBN
cord-019001-ralxw4ad	501	24	in	in	IN
cord-019001-ralxw4ad	501	25	utero	utero	NNS
cord-019001-ralxw4ad	501	26	to	to	IN
cord-019001-ralxw4ad	501	27	prostaglandin	prostaglandin	NN
cord-019001-ralxw4ad	501	28	synthetase	synthetase	NN
cord-019001-ralxw4ad	501	29	inhibitors	inhibitor	NNS
cord-019001-ralxw4ad	502	1	The	the	DT
cord-019001-ralxw4ad	502	2	therapeutic	therapeutic	JJ
cord-019001-ralxw4ad	502	3	application	application	NN
cord-019001-ralxw4ad	502	4	of	of	IN
cord-019001-ralxw4ad	502	5	end	end	NN
cord-019001-ralxw4ad	502	6	-	-	HYPH
cord-019001-ralxw4ad	502	7	expiratory	expiratory	NN
cord-019001-ralxw4ad	502	8	pressure	pressure	NN
cord-019001-ralxw4ad	502	9	in	in	IN
cord-019001-ralxw4ad	502	10	the	the	DT
cord-019001-ralxw4ad	502	11	meconium	meconium	NN
cord-019001-ralxw4ad	502	12	aspiration	aspiration	NN
cord-019001-ralxw4ad	502	13	syndrome	syndrome	NN
cord-019001-ralxw4ad	502	14	Effects	effect	NNS
cord-019001-ralxw4ad	502	15	of	of	IN
cord-019001-ralxw4ad	502	16	PEEP	peep	NN
cord-019001-ralxw4ad	502	17	and	and	CC
cord-019001-ralxw4ad	502	18	tolazoline	tolazoline	NN
cord-019001-ralxw4ad	502	19	infusion	infusion	NN
cord-019001-ralxw4ad	502	20	on	on	IN
cord-019001-ralxw4ad	502	21	respiratory	respiratory	JJ
cord-019001-ralxw4ad	502	22	and	and	CC
cord-019001-ralxw4ad	502	23	inert	inert	JJ
cord-019001-ralxw4ad	502	24	gas	gas	NN
cord-019001-ralxw4ad	502	25	exchange	exchange	NN
cord-019001-ralxw4ad	502	26	in	in	IN
cord-019001-ralxw4ad	502	27	experimental	experimental	JJ
cord-019001-ralxw4ad	502	28	meconium	meconium	NN
cord-019001-ralxw4ad	502	29	aspiration	aspiration	NN
cord-019001-ralxw4ad	502	30	Surfactant	Surfactant	NNP
cord-019001-ralxw4ad	502	31	treatment	treatment	NN
cord-019001-ralxw4ad	502	32	of	of	IN
cord-019001-ralxw4ad	502	33	full	full	JJ
cord-019001-ralxw4ad	502	34	-	-	HYPH
cord-019001-ralxw4ad	502	35	term	term	NN
cord-019001-ralxw4ad	502	36	newborns	newborn	NNS
cord-019001-ralxw4ad	502	37	with	with	IN
cord-019001-ralxw4ad	502	38	respiratory	respiratory	JJ
cord-019001-ralxw4ad	502	39	failure	failure	NN
cord-019001-ralxw4ad	502	40	Respiratory	respiratory	JJ
cord-019001-ralxw4ad	502	41	paralysis	paralysis	NN
cord-019001-ralxw4ad	502	42	to	to	TO
cord-019001-ralxw4ad	502	43	improve	improve	VB
cord-019001-ralxw4ad	502	44	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	502	45	and	and	CC
cord-019001-ralxw4ad	502	46	mortality	mortality	NN
cord-019001-ralxw4ad	502	47	in	in	IN
cord-019001-ralxw4ad	502	48	large	large	JJ
cord-019001-ralxw4ad	502	49	newborn	newborn	JJ
cord-019001-ralxw4ad	502	50	infants	infant	NNS
cord-019001-ralxw4ad	502	51	with	with	IN
cord-019001-ralxw4ad	502	52	respiratory	respiratory	JJ
cord-019001-ralxw4ad	502	53	distress	distress	NN
cord-019001-ralxw4ad	502	54	National	national	JJ
cord-019001-ralxw4ad	502	55	experience	experience	NN
cord-019001-ralxw4ad	502	56	with	with	IN
cord-019001-ralxw4ad	502	57	extracorporeal	extracorporeal	JJ
cord-019001-ralxw4ad	502	58	membrane	membrane	NN
cord-019001-ralxw4ad	502	59	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	502	60	for	for	IN
cord-019001-ralxw4ad	502	61	newborn	newborn	JJ
cord-019001-ralxw4ad	502	62	respiratory	respiratory	JJ
cord-019001-ralxw4ad	502	63	failure	failure	NN
cord-019001-ralxw4ad	502	64	.	.	.
cord-019001-ralxw4ad	503	1	Data	datum	NNS
cord-019001-ralxw4ad	503	2	from	from	IN
cord-019001-ralxw4ad	503	3	715	715	CD
cord-019001-ralxw4ad	503	4	cases	case	NNS
cord-019001-ralxw4ad	504	1	Extracorporeal	extracorporeal	JJ
cord-019001-ralxw4ad	504	2	membrane	membrane	NN
cord-019001-ralxw4ad	504	3	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	504	4	and	and	CC
cord-019001-ralxw4ad	504	5	conventional	conventional	JJ
cord-019001-ralxw4ad	504	6	medical	medical	JJ
cord-019001-ralxw4ad	504	7	therapy	therapy	NN
cord-019001-ralxw4ad	504	8	in	in	IN
cord-019001-ralxw4ad	504	9	neonates	neonate	NNS
cord-019001-ralxw4ad	504	10	with	with	IN
cord-019001-ralxw4ad	504	11	persistent	persistent	JJ
cord-019001-ralxw4ad	504	12	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	504	13	hypertension	hypertension	NN
cord-019001-ralxw4ad	504	14	of	of	IN
cord-019001-ralxw4ad	504	15	the	the	DT
cord-019001-ralxw4ad	504	16	newborn	newborn	NN
cord-019001-ralxw4ad	504	17	:	:	:
cord-019001-ralxw4ad	505	1	a	a	DT
cord-019001-ralxw4ad	505	2	prospective	prospective	JJ
cord-019001-ralxw4ad	505	3	randomized	randomized	JJ
cord-019001-ralxw4ad	505	4	study	study	NN
cord-019001-ralxw4ad	505	5	Extracorporeal	extracorporeal	JJ
cord-019001-ralxw4ad	505	6	membrane	membrane	NN
cord-019001-ralxw4ad	505	7	oxygenation	oxygenation	NN
cord-019001-ralxw4ad	505	8	trials	trial	NNS
cord-019001-ralxw4ad	505	9	ECMO	ECMO	NNP
cord-019001-ralxw4ad	505	10	for	for	IN
cord-019001-ralxw4ad	505	11	neonatal	neonatal	JJ
cord-019001-ralxw4ad	505	12	respiratory	respiratory	JJ
cord-019001-ralxw4ad	505	13	failure	failure	NN
cord-019001-ralxw4ad	506	1	The	the	DT
cord-019001-ralxw4ad	506	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	506	3	circulation	circulation	NN
cord-019001-ralxw4ad	506	4	:	:	:
cord-019001-ralxw4ad	506	5	remodeling	remodeling	NN
cord-019001-ralxw4ad	506	6	in	in	IN
cord-019001-ralxw4ad	506	7	growth	growth	NN
cord-019001-ralxw4ad	506	8	and	and	CC
cord-019001-ralxw4ad	506	9	disease	disease	NN
cord-019001-ralxw4ad	506	10	.	.	.
cord-019001-ralxw4ad	507	1	The	the	DT
cord-019001-ralxw4ad	507	2	1978	1978	CD
cord-019001-ralxw4ad	507	3	J.	J.	NNP
cord-019001-ralxw4ad	507	4	Burns	Burns	NNP
cord-019001-ralxw4ad	507	5	Amberson	Amberson	NNP
cord-019001-ralxw4ad	507	6	lecture	lecture	NN
cord-019001-ralxw4ad	508	1	Vascular	vascular	JJ
cord-019001-ralxw4ad	508	2	structure	structure	NN
cord-019001-ralxw4ad	508	3	in	in	IN
cord-019001-ralxw4ad	508	4	lung	lung	NN
cord-019001-ralxw4ad	508	5	tissue	tissue	NN
cord-019001-ralxw4ad	508	6	obtained	obtain	VBN
cord-019001-ralxw4ad	508	7	at	at	IN
cord-019001-ralxw4ad	508	8	biopsy	biopsy	NN
cord-019001-ralxw4ad	508	9	correlated	correlate	VBN
cord-019001-ralxw4ad	508	10	with	with	IN
cord-019001-ralxw4ad	508	11	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	508	12	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	508	13	fi	fi	NN
cord-019001-ralxw4ad	508	14	ndings	nding	NNS
cord-019001-ralxw4ad	508	15	after	after	IN
cord-019001-ralxw4ad	508	16	repair	repair	NN
cord-019001-ralxw4ad	508	17	of	of	IN
cord-019001-ralxw4ad	508	18	congenital	congenital	JJ
cord-019001-ralxw4ad	508	19	heart	heart	NN
cord-019001-ralxw4ad	508	20	defects	defect	NNS
cord-019001-ralxw4ad	509	1	Quantitative	quantitative	JJ
cord-019001-ralxw4ad	509	2	structural	structural	JJ
cord-019001-ralxw4ad	509	3	study	study	NN
cord-019001-ralxw4ad	509	4	of	of	IN
cord-019001-ralxw4ad	509	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	509	6	circulation	circulation	NN
cord-019001-ralxw4ad	509	7	in	in	IN
cord-019001-ralxw4ad	509	8	the	the	DT
cord-019001-ralxw4ad	509	9	newborn	newborn	NN
cord-019001-ralxw4ad	509	10	with	with	IN
cord-019001-ralxw4ad	509	11	aortic	aortic	JJ
cord-019001-ralxw4ad	509	12	atresia	atresia	NN
cord-019001-ralxw4ad	509	13	,	,	,
cord-019001-ralxw4ad	509	14	stenosis	stenosis	NN
cord-019001-ralxw4ad	509	15	,	,	,
cord-019001-ralxw4ad	509	16	or	or	CC
cord-019001-ralxw4ad	509	17	coarctation	coarctation	NN
cord-019001-ralxw4ad	510	1	The	the	DT
cord-019001-ralxw4ad	510	2	pathology	pathology	NN
cord-019001-ralxw4ad	510	3	of	of	IN
cord-019001-ralxw4ad	510	4	hypertensive	hypertensive	JJ
cord-019001-ralxw4ad	510	5	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	510	6	vascular	vascular	JJ
cord-019001-ralxw4ad	510	7	disease	disease	NN
cord-019001-ralxw4ad	510	8	;	;	:
cord-019001-ralxw4ad	510	9	a	a	DT
cord-019001-ralxw4ad	510	10	description	description	NN
cord-019001-ralxw4ad	510	11	of	of	IN
cord-019001-ralxw4ad	510	12	six	six	CD
cord-019001-ralxw4ad	510	13	grades	grade	NNS
cord-019001-ralxw4ad	510	14	of	of	IN
cord-019001-ralxw4ad	510	15	structural	structural	JJ
cord-019001-ralxw4ad	510	16	changes	change	NNS
cord-019001-ralxw4ad	510	17	in	in	IN
cord-019001-ralxw4ad	510	18	the	the	DT
cord-019001-ralxw4ad	510	19	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	510	20	arteries	artery	NNS
cord-019001-ralxw4ad	510	21	with	with	IN
cord-019001-ralxw4ad	510	22	special	special	JJ
cord-019001-ralxw4ad	510	23	reference	reference	NN
cord-019001-ralxw4ad	510	24	to	to	IN
cord-019001-ralxw4ad	510	25	congenital	congenital	JJ
cord-019001-ralxw4ad	510	26	cardiac	cardiac	JJ
cord-019001-ralxw4ad	510	27	septal	septal	JJ
cord-019001-ralxw4ad	510	28	defects	defect	NNS
cord-019001-ralxw4ad	510	29	Down	down	IN
cord-019001-ralxw4ad	510	30	's	's	POS
cord-019001-ralxw4ad	510	31	syndrome	syndrome	NN
cord-019001-ralxw4ad	510	32	,	,	,
cord-019001-ralxw4ad	510	33	complete	complete	JJ
cord-019001-ralxw4ad	510	34	atrioventricular	atrioventricular	JJ
cord-019001-ralxw4ad	510	35	canal	canal	NN
cord-019001-ralxw4ad	510	36	,	,	,
cord-019001-ralxw4ad	510	37	and	and	CC
cord-019001-ralxw4ad	510	38	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	510	39	vascular	vascular	JJ
cord-019001-ralxw4ad	510	40	obstructive	obstructive	JJ
cord-019001-ralxw4ad	510	41	disease	disease	NN
cord-019001-ralxw4ad	510	42	Effects	effect	NNS
cord-019001-ralxw4ad	510	43	of	of	IN
cord-019001-ralxw4ad	510	44	surgical	surgical	JJ
cord-019001-ralxw4ad	510	45	closure	closure	NN
cord-019001-ralxw4ad	510	46	of	of	IN
cord-019001-ralxw4ad	510	47	ventricular	ventricular	JJ
cord-019001-ralxw4ad	510	48	septal	septal	JJ
cord-019001-ralxw4ad	510	49	defects	defect	NNS
cord-019001-ralxw4ad	510	50	upon	upon	IN
cord-019001-ralxw4ad	510	51	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	510	52	vascular	vascular	JJ
cord-019001-ralxw4ad	510	53	disease	disease	NN
cord-019001-ralxw4ad	510	54	Use	use	NN
cord-019001-ralxw4ad	510	55	of	of	IN
cord-019001-ralxw4ad	510	56	inhaled	inhale	VBN
cord-019001-ralxw4ad	510	57	nitric	nitric	NN
cord-019001-ralxw4ad	510	58	oxide	oxide	NN
cord-019001-ralxw4ad	510	59	and	and	CC
cord-019001-ralxw4ad	510	60	acetylcholine	acetylcholine	NN
cord-019001-ralxw4ad	510	61	in	in	IN
cord-019001-ralxw4ad	510	62	the	the	DT
cord-019001-ralxw4ad	510	63	evaluation	evaluation	NN
cord-019001-ralxw4ad	510	64	of	of	IN
cord-019001-ralxw4ad	510	65	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	510	66	hypertension	hypertension	NN
cord-019001-ralxw4ad	510	67	and	and	CC
cord-019001-ralxw4ad	510	68	endothelial	endothelial	JJ
cord-019001-ralxw4ad	510	69	function	function	NN
cord-019001-ralxw4ad	510	70	after	after	IN
cord-019001-ralxw4ad	510	71	cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	510	72	bypass	bypass	NN
cord-019001-ralxw4ad	510	73	Combined	combine	VBN
cord-019001-ralxw4ad	510	74	effects	effect	NNS
cord-019001-ralxw4ad	510	75	of	of	IN
cord-019001-ralxw4ad	510	76	nitric	nitric	NN
cord-019001-ralxw4ad	510	77	oxide	oxide	NN
cord-019001-ralxw4ad	510	78	and	and	CC
cord-019001-ralxw4ad	510	79	oxygen	oxygen	NN
cord-019001-ralxw4ad	510	80	during	during	IN
cord-019001-ralxw4ad	510	81	acute	acute	JJ
cord-019001-ralxw4ad	510	82	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	510	83	vasodilator	vasodilator	NN
cord-019001-ralxw4ad	510	84	testing	testing	NN
cord-019001-ralxw4ad	510	85	Inhaled	inhale	VBD
cord-019001-ralxw4ad	510	86	Nitric	Nitric	NNP
cord-019001-ralxw4ad	510	87	Oxide	Oxide	NNP
cord-019001-ralxw4ad	510	88	as	as	IN
cord-019001-ralxw4ad	510	89	a	a	DT
cord-019001-ralxw4ad	510	90	Preoperative	Preoperative	NNP
cord-019001-ralxw4ad	510	91	Test	test	NN
cord-019001-ralxw4ad	510	92	(	(	-LRB-
cord-019001-ralxw4ad	510	93	INOP	INOP	NNP
cord-019001-ralxw4ad	510	94	Test	test	NN
cord-019001-ralxw4ad	510	95	I	i	NN
cord-019001-ralxw4ad	510	96	)	)	-RRB-
cord-019001-ralxw4ad	510	97	:	:	:
cord-019001-ralxw4ad	510	98	the	the	DT
cord-019001-ralxw4ad	510	99	INOP	INOP	NNP
cord-019001-ralxw4ad	510	100	Test	Test	NNP
cord-019001-ralxw4ad	510	101	Study	Study	NNP
cord-019001-ralxw4ad	510	102	Group	Group	NNP
cord-019001-ralxw4ad	510	103	Inhaled	Inhaled	NNP
cord-019001-ralxw4ad	510	104	nitric	nitric	NN
cord-019001-ralxw4ad	510	105	oxide	oxide	NN
cord-019001-ralxw4ad	510	106	and	and	CC
cord-019001-ralxw4ad	510	107	congenital	congenital	JJ
cord-019001-ralxw4ad	510	108	cardiac	cardiac	JJ
cord-019001-ralxw4ad	510	109	disease	disease	NN
cord-019001-ralxw4ad	511	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	511	2	nitric	nitric	NN
cord-019001-ralxw4ad	511	3	oxide	oxide	NN
cord-019001-ralxw4ad	511	4	therapy	therapy	NN
cord-019001-ralxw4ad	511	5	after	after	IN
cord-019001-ralxw4ad	511	6	Fontan	Fontan	NNP
cord-019001-ralxw4ad	511	7	-	-	HYPH
cord-019001-ralxw4ad	511	8	type	type	NN
cord-019001-ralxw4ad	511	9	operations	operation	NNS
cord-019001-ralxw4ad	511	10	Inhaled	inhale	VBD
cord-019001-ralxw4ad	511	11	nitric	nitric	JJ
cord-019001-ralxw4ad	511	12	oxide	oxide	NN
cord-019001-ralxw4ad	511	13	in	in	IN
cord-019001-ralxw4ad	511	14	pediatric	pediatric	JJ
cord-019001-ralxw4ad	511	15	cardiac	cardiac	NN
cord-019001-ralxw4ad	511	16	surgery	surgery	NN
cord-019001-ralxw4ad	512	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	512	2	nitric	nitric	NN
cord-019001-ralxw4ad	512	3	oxide	oxide	NN
cord-019001-ralxw4ad	512	4	and	and	CC
cord-019001-ralxw4ad	512	5	prevention	prevention	NN
cord-019001-ralxw4ad	512	6	of	of	IN
cord-019001-ralxw4ad	512	7	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	512	8	hypertension	hypertension	NN
cord-019001-ralxw4ad	512	9	after	after	IN
cord-019001-ralxw4ad	512	10	congenital	congenital	JJ
cord-019001-ralxw4ad	512	11	heart	heart	NN
cord-019001-ralxw4ad	512	12	surgery	surgery	NN
cord-019001-ralxw4ad	512	13	:	:	:
cord-019001-ralxw4ad	512	14	a	a	DT
cord-019001-ralxw4ad	512	15	randomised	randomised	JJ
cord-019001-ralxw4ad	512	16	double	double	JJ
cord-019001-ralxw4ad	512	17	-	-	HYPH
cord-019001-ralxw4ad	512	18	blind	blind	JJ
cord-019001-ralxw4ad	512	19	study	study	NN
cord-019001-ralxw4ad	512	20	Clinical	clinical	JJ
cord-019001-ralxw4ad	512	21	classifi	classifi	NN
cord-019001-ralxw4ad	512	22	cation	cation	NN
cord-019001-ralxw4ad	512	23	of	of	IN
cord-019001-ralxw4ad	512	24	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	512	25	hypertension	hypertension	NN
cord-019001-ralxw4ad	512	26	Survival	Survival	NNP
cord-019001-ralxw4ad	512	27	in	in	IN
cord-019001-ralxw4ad	512	28	patients	patient	NNS
cord-019001-ralxw4ad	512	29	with	with	IN
cord-019001-ralxw4ad	512	30	primary	primary	JJ
cord-019001-ralxw4ad	512	31	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	512	32	hypertension	hypertension	NN
cord-019001-ralxw4ad	512	33	.	.	.
cord-019001-ralxw4ad	513	1	Results	result	NNS
cord-019001-ralxw4ad	513	2	from	from	IN
cord-019001-ralxw4ad	513	3	a	a	DT
cord-019001-ralxw4ad	513	4	national	national	JJ
cord-019001-ralxw4ad	513	5	prospective	prospective	JJ
cord-019001-ralxw4ad	513	6	registry	registry	NN
cord-019001-ralxw4ad	513	7	Comparison	comparison	NN
cord-019001-ralxw4ad	513	8	of	of	IN
cord-019001-ralxw4ad	513	9	primary	primary	JJ
cord-019001-ralxw4ad	513	10	plexogenic	plexogenic	NN
cord-019001-ralxw4ad	513	11	arteriopathy	arteriopathy	FW
cord-019001-ralxw4ad	513	12	in	in	IN
cord-019001-ralxw4ad	513	13	adults	adult	NNS
cord-019001-ralxw4ad	513	14	and	and	CC
cord-019001-ralxw4ad	513	15	children	child	NNS
cord-019001-ralxw4ad	513	16	.	.	.
cord-019001-ralxw4ad	514	1	A	a	DT
cord-019001-ralxw4ad	514	2	morphometric	morphometric	JJ
cord-019001-ralxw4ad	514	3	study	study	NN
cord-019001-ralxw4ad	514	4	in	in	IN
cord-019001-ralxw4ad	514	5	40	40	CD
cord-019001-ralxw4ad	514	6	patients	patient	NNS
cord-019001-ralxw4ad	514	7	Primary	primary	JJ
cord-019001-ralxw4ad	514	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	514	9	hypertension	hypertension	NN
cord-019001-ralxw4ad	514	10	in	in	IN
cord-019001-ralxw4ad	514	11	children	child	NNS
cord-019001-ralxw4ad	514	12	:	:	:
cord-019001-ralxw4ad	514	13	clinical	clinical	JJ
cord-019001-ralxw4ad	514	14	characterization	characterization	NN
cord-019001-ralxw4ad	514	15	and	and	CC
cord-019001-ralxw4ad	514	16	survival	survival	NN
cord-019001-ralxw4ad	515	1	Primary	primary	JJ
cord-019001-ralxw4ad	515	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	515	3	hypertension	hypertension	NN
cord-019001-ralxw4ad	515	4	.	.	.
cord-019001-ralxw4ad	516	1	A	a	DT
cord-019001-ralxw4ad	516	2	national	national	JJ
cord-019001-ralxw4ad	516	3	prospective	prospective	JJ
cord-019001-ralxw4ad	516	4	study	study	NN
cord-019001-ralxw4ad	516	5	Relation	Relation	NNP
cord-019001-ralxw4ad	516	6	of	of	IN
cord-019001-ralxw4ad	516	7	arachidonate	arachidonate	NN
cord-019001-ralxw4ad	516	8	metabolites	metabolite	NNS
cord-019001-ralxw4ad	516	9	to	to	IN
cord-019001-ralxw4ad	516	10	abnormal	abnormal	JJ
cord-019001-ralxw4ad	516	11	control	control	NN
cord-019001-ralxw4ad	516	12	of	of	IN
cord-019001-ralxw4ad	516	13	the	the	DT
cord-019001-ralxw4ad	516	14	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	516	15	circulation	circulation	NN
cord-019001-ralxw4ad	516	16	in	in	IN
cord-019001-ralxw4ad	516	17	a	a	DT
cord-019001-ralxw4ad	516	18	child	child	NN
cord-019001-ralxw4ad	516	19	Practical	practical	JJ
cord-019001-ralxw4ad	516	20	method	method	NN
cord-019001-ralxw4ad	516	21	for	for	IN
cord-019001-ralxw4ad	516	22	quantifying	quantify	VBG
cord-019001-ralxw4ad	516	23	hearing	hear	VBG
cord-019001-ralxw4ad	516	24	aid	aid	NN
cord-019001-ralxw4ad	516	25	benefi	benefi	NNP
cord-019001-ralxw4ad	516	26	t	t	NN
cord-019001-ralxw4ad	516	27	in	in	IN
cord-019001-ralxw4ad	516	28	older	old	JJR
cord-019001-ralxw4ad	516	29	adults	adult	NNS
cord-019001-ralxw4ad	516	30	Increased	increase	VBD
cord-019001-ralxw4ad	516	31	plasma	plasma	NN
cord-019001-ralxw4ad	516	32	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	516	33	in	in	IN
cord-019001-ralxw4ad	516	34	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	516	35	hypertension	hypertension	NN
cord-019001-ralxw4ad	516	36	:	:	:
cord-019001-ralxw4ad	517	1	marker	marker	NN
cord-019001-ralxw4ad	517	2	or	or	CC
cord-019001-ralxw4ad	517	3	mediator	mediator	NN
cord-019001-ralxw4ad	517	4	of	of	IN
cord-019001-ralxw4ad	517	5	disease	disease	NN
cord-019001-ralxw4ad	517	6	?	?	.
cord-019001-ralxw4ad	518	1	Nitric	nitric	NN
cord-019001-ralxw4ad	518	2	oxide	oxide	NN
cord-019001-ralxw4ad	518	3	and	and	CC
cord-019001-ralxw4ad	518	4	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	518	5	in	in	IN
cord-019001-ralxw4ad	518	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	518	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	519	1	Dysfunctional	dysfunctional	JJ
cord-019001-ralxw4ad	519	2	voltage	voltage	NN
cord-019001-ralxw4ad	519	3	-	-	HYPH
cord-019001-ralxw4ad	519	4	gated	gate	VBN
cord-019001-ralxw4ad	519	5	K+	k+	JJ
cord-019001-ralxw4ad	519	6	channels	channel	NNS
cord-019001-ralxw4ad	519	7	in	in	IN
cord-019001-ralxw4ad	519	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	519	9	artery	artery	NN
cord-019001-ralxw4ad	519	10	smooth	smooth	JJ
cord-019001-ralxw4ad	519	11	muscle	muscle	NN
cord-019001-ralxw4ad	519	12	cells	cell	NNS
cord-019001-ralxw4ad	519	13	of	of	IN
cord-019001-ralxw4ad	519	14	patients	patient	NNS
cord-019001-ralxw4ad	519	15	with	with	IN
cord-019001-ralxw4ad	519	16	primary	primary	JJ
cord-019001-ralxw4ad	519	17	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	519	18	hypertension	hypertension	NN
cord-019001-ralxw4ad	519	19	Abnormal	abnormal	JJ
cord-019001-ralxw4ad	519	20	endothelial	endothelial	JJ
cord-019001-ralxw4ad	519	21	factor	factor	NN
cord-019001-ralxw4ad	519	22	VIII	VIII	NNP
cord-019001-ralxw4ad	519	23	associated	associate	VBN
cord-019001-ralxw4ad	519	24	with	with	IN
cord-019001-ralxw4ad	519	25	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	519	26	hypertension	hypertension	NN
cord-019001-ralxw4ad	519	27	and	and	CC
cord-019001-ralxw4ad	519	28	congenital	congenital	JJ
cord-019001-ralxw4ad	519	29	heart	heart	NN
cord-019001-ralxw4ad	519	30	defects	defect	NNS
cord-019001-ralxw4ad	519	31	von	von	NNP
cord-019001-ralxw4ad	519	32	Willebrand	Willebrand	NNP
cord-019001-ralxw4ad	519	33	factor	factor	NN
cord-019001-ralxw4ad	519	34	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	519	35	in	in	IN
cord-019001-ralxw4ad	519	36	primary	primary	JJ
cord-019001-ralxw4ad	519	37	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	519	38	hypertension	hypertension	NN
cord-019001-ralxw4ad	519	39	Primary	primary	JJ
cord-019001-ralxw4ad	519	40	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	519	41	hypertension	hypertension	NN
cord-019001-ralxw4ad	519	42	:	:	:
cord-019001-ralxw4ad	519	43	natural	natural	JJ
cord-019001-ralxw4ad	519	44	history	history	NN
cord-019001-ralxw4ad	519	45	and	and	CC
cord-019001-ralxw4ad	519	46	the	the	DT
cord-019001-ralxw4ad	519	47	importance	importance	NN
cord-019001-ralxw4ad	519	48	of	of	IN
cord-019001-ralxw4ad	519	49	thrombosis	thrombosis	NN
cord-019001-ralxw4ad	520	1	The	the	DT
cord-019001-ralxw4ad	520	2	effect	effect	NN
cord-019001-ralxw4ad	520	3	of	of	IN
cord-019001-ralxw4ad	520	4	anticoagulant	anticoagulant	JJ
cord-019001-ralxw4ad	520	5	therapy	therapy	NN
cord-019001-ralxw4ad	520	6	in	in	IN
cord-019001-ralxw4ad	520	7	primary	primary	JJ
cord-019001-ralxw4ad	520	8	and	and	CC
cord-019001-ralxw4ad	520	9	anorectic	anorectic	JJ
cord-019001-ralxw4ad	520	10	drug	drug	NN
cord-019001-ralxw4ad	520	11	-	-	HYPH
cord-019001-ralxw4ad	520	12	induced	induce	VBN
cord-019001-ralxw4ad	520	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	520	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	520	15	Inhibition	inhibition	NN
cord-019001-ralxw4ad	520	16	of	of	IN
cord-019001-ralxw4ad	520	17	hypoxic	hypoxic	JJ
cord-019001-ralxw4ad	520	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	520	19	hypertension	hypertension	NN
cord-019001-ralxw4ad	520	20	by	by	IN
cord-019001-ralxw4ad	520	21	heparins	heparin	NNS
cord-019001-ralxw4ad	520	22	of	of	IN
cord-019001-ralxw4ad	520	23	differing	differ	VBG
cord-019001-ralxw4ad	521	1	in	in	IN
cord-019001-ralxw4ad	521	2	vitro	vitro	FW
cord-019001-ralxw4ad	521	3	antiproliferative	antiproliferative	NNP
cord-019001-ralxw4ad	521	4	potency	potency	NNP
cord-019001-ralxw4ad	522	1	The	the	DT
cord-019001-ralxw4ad	522	2	effect	effect	NN
cord-019001-ralxw4ad	522	3	of	of	IN
cord-019001-ralxw4ad	522	4	high	high	JJ
cord-019001-ralxw4ad	522	5	doses	dose	NNS
cord-019001-ralxw4ad	522	6	of	of	IN
cord-019001-ralxw4ad	522	7	calciumchannel	calciumchannel	NNP
cord-019001-ralxw4ad	522	8	blockers	blocker	NNS
cord-019001-ralxw4ad	522	9	on	on	IN
cord-019001-ralxw4ad	522	10	survival	survival	NN
cord-019001-ralxw4ad	522	11	in	in	IN
cord-019001-ralxw4ad	522	12	primary	primary	JJ
cord-019001-ralxw4ad	522	13	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	522	14	hypertension	hypertension	NN
cord-019001-ralxw4ad	522	15	Short	short	JJ
cord-019001-ralxw4ad	522	16	-	-	HYPH
cord-019001-ralxw4ad	522	17	term	term	NN
cord-019001-ralxw4ad	522	18	hemodynamic	hemodynamic	JJ
cord-019001-ralxw4ad	522	19	effect	effect	NN
cord-019001-ralxw4ad	522	20	of	of	IN
cord-019001-ralxw4ad	522	21	a	a	DT
cord-019001-ralxw4ad	522	22	new	new	JJ
cord-019001-ralxw4ad	522	23	oral	oral	JJ
cord-019001-ralxw4ad	522	24	PGI2	PGI2	NNP
cord-019001-ralxw4ad	522	25	analogue	analogue	NN
cord-019001-ralxw4ad	522	26	,	,	,
cord-019001-ralxw4ad	522	27	beraprost	beraprost	NN
cord-019001-ralxw4ad	522	28	,	,	,
cord-019001-ralxw4ad	522	29	in	in	IN
cord-019001-ralxw4ad	522	30	primary	primary	JJ
cord-019001-ralxw4ad	522	31	and	and	CC
cord-019001-ralxw4ad	522	32	secondary	secondary	JJ
cord-019001-ralxw4ad	522	33	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	522	34	hypertension	hypertension	NN
cord-019001-ralxw4ad	522	35	Effect	effect	NN
cord-019001-ralxw4ad	522	36	of	of	IN
cord-019001-ralxw4ad	522	37	orally	orally	RB
cord-019001-ralxw4ad	522	38	active	active	JJ
cord-019001-ralxw4ad	522	39	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	522	40	analogue	analogue	NN
cord-019001-ralxw4ad	522	41	on	on	IN
cord-019001-ralxw4ad	522	42	survival	survival	NN
cord-019001-ralxw4ad	522	43	of	of	IN
cord-019001-ralxw4ad	522	44	outpatients	outpatient	NNS
cord-019001-ralxw4ad	522	45	with	with	IN
cord-019001-ralxw4ad	522	46	primary	primary	JJ
cord-019001-ralxw4ad	522	47	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	522	48	hypertension	hypertension	NN
cord-019001-ralxw4ad	522	49	Long	long	JJ
cord-019001-ralxw4ad	522	50	-	-	HYPH
cord-019001-ralxw4ad	522	51	term	term	NN
cord-019001-ralxw4ad	522	52	treatment	treatment	NN
cord-019001-ralxw4ad	522	53	of	of	IN
cord-019001-ralxw4ad	522	54	primary	primary	JJ
cord-019001-ralxw4ad	522	55	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	522	56	hypertension	hypertension	NN
cord-019001-ralxw4ad	522	57	with	with	IN
cord-019001-ralxw4ad	522	58	aerosolized	aerosolize	VBN
cord-019001-ralxw4ad	522	59	iloprost	iloprost	NN
cord-019001-ralxw4ad	522	60	,	,	,
cord-019001-ralxw4ad	522	61	a	a	DT
cord-019001-ralxw4ad	522	62	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	522	63	analogue	analogue	NN
cord-019001-ralxw4ad	522	64	Treatment	Treatment	NNP
cord-019001-ralxw4ad	522	65	of	of	IN
cord-019001-ralxw4ad	522	66	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	522	67	hypertension	hypertension	NN
cord-019001-ralxw4ad	522	68	with	with	IN
cord-019001-ralxw4ad	522	69	the	the	DT
cord-019001-ralxw4ad	522	70	continuous	continuous	JJ
cord-019001-ralxw4ad	522	71	infusion	infusion	NN
cord-019001-ralxw4ad	522	72	of	of	IN
cord-019001-ralxw4ad	522	73	a	a	DT
cord-019001-ralxw4ad	522	74	prostacyclin	prostacyclin	JJ
cord-019001-ralxw4ad	522	75	analogue	analogue	NN
cord-019001-ralxw4ad	522	76	,	,	,
cord-019001-ralxw4ad	523	1	iloprost	iloprost	NNP
cord-019001-ralxw4ad	524	1	The	the	DT
cord-019001-ralxw4ad	524	2	short	short	JJ
cord-019001-ralxw4ad	524	3	-	-	HYPH
cord-019001-ralxw4ad	524	4	term	term	NN
cord-019001-ralxw4ad	524	5	effects	effect	NNS
cord-019001-ralxw4ad	524	6	of	of	IN
cord-019001-ralxw4ad	524	7	digoxin	digoxin	NN
cord-019001-ralxw4ad	524	8	in	in	IN
cord-019001-ralxw4ad	524	9	patients	patient	NNS
cord-019001-ralxw4ad	524	10	with	with	IN
cord-019001-ralxw4ad	524	11	right	right	JJ
cord-019001-ralxw4ad	524	12	ventricular	ventricular	JJ
cord-019001-ralxw4ad	524	13	dysfunction	dysfunction	NN
cord-019001-ralxw4ad	524	14	from	from	IN
cord-019001-ralxw4ad	524	15	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	524	16	hypertension	hypertension	NN
cord-019001-ralxw4ad	524	17	Elastase	Elastase	NNP
cord-019001-ralxw4ad	524	18	and	and	CC
cord-019001-ralxw4ad	524	19	matrix	matrix	NN
cord-019001-ralxw4ad	524	20	metalloproteinase	metalloproteinase	NN
cord-019001-ralxw4ad	524	21	inhibitors	inhibitor	NNS
cord-019001-ralxw4ad	524	22	induce	induce	VBP
cord-019001-ralxw4ad	524	23	regression	regression	NN
cord-019001-ralxw4ad	524	24	,	,	,
cord-019001-ralxw4ad	524	25	and	and	CC
cord-019001-ralxw4ad	524	26	tenascin	tenascin	NNP
cord-019001-ralxw4ad	524	27	-	-	HYPH
cord-019001-ralxw4ad	524	28	C	c	NN
cord-019001-ralxw4ad	524	29	antisense	antisense	NN
cord-019001-ralxw4ad	524	30	prevents	prevent	VBZ
cord-019001-ralxw4ad	524	31	progression	progression	NN
cord-019001-ralxw4ad	524	32	,	,	,
cord-019001-ralxw4ad	524	33	of	of	IN
cord-019001-ralxw4ad	524	34	vascular	vascular	JJ
cord-019001-ralxw4ad	524	35	disease	disease	NN
cord-019001-ralxw4ad	524	36	Complete	complete	JJ
cord-019001-ralxw4ad	524	37	reversal	reversal	NN
cord-019001-ralxw4ad	524	38	of	of	IN
cord-019001-ralxw4ad	524	39	fatal	fatal	JJ
cord-019001-ralxw4ad	524	40	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	524	41	hypertension	hypertension	NN
cord-019001-ralxw4ad	524	42	in	in	IN
cord-019001-ralxw4ad	524	43	rats	rat	NNS
cord-019001-ralxw4ad	524	44	by	by	IN
cord-019001-ralxw4ad	524	45	a	a	DT
cord-019001-ralxw4ad	524	46	serine	serine	JJ
cord-019001-ralxw4ad	524	47	elastase	elastase	NN
cord-019001-ralxw4ad	524	48	inhibitor	inhibitor	NN
cord-019001-ralxw4ad	524	49	Role	role	NN
cord-019001-ralxw4ad	524	50	of	of	IN
cord-019001-ralxw4ad	524	51	atrial	atrial	JJ
cord-019001-ralxw4ad	524	52	septostomy	septostomy	NN
cord-019001-ralxw4ad	524	53	in	in	IN
cord-019001-ralxw4ad	524	54	the	the	DT
cord-019001-ralxw4ad	524	55	treatment	treatment	NN
cord-019001-ralxw4ad	524	56	of	of	IN
cord-019001-ralxw4ad	524	57	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	524	58	vascular	vascular	JJ
cord-019001-ralxw4ad	524	59	disease	disease	NN
cord-019001-ralxw4ad	524	60	Paediatric	paediatric	JJ
cord-019001-ralxw4ad	524	61	lung	lung	NN
cord-019001-ralxw4ad	524	62	transplantation	transplantation	NN
cord-019001-ralxw4ad	524	63	Lung	lung	NN
cord-019001-ralxw4ad	524	64	transplantation	transplantation	NN
cord-019001-ralxw4ad	524	65	for	for	IN
cord-019001-ralxw4ad	524	66	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	524	67	vascular	vascular	JJ
cord-019001-ralxw4ad	524	68	disease	disease	NN
cord-019001-ralxw4ad	524	69	Registry	registry	NN
cord-019001-ralxw4ad	524	70	for	for	IN
cord-019001-ralxw4ad	524	71	the	the	DT
cord-019001-ralxw4ad	524	72	International	International	NNP
cord-019001-ralxw4ad	524	73	Society	Society	NNP
cord-019001-ralxw4ad	524	74	for	for	IN
cord-019001-ralxw4ad	524	75	Heart	Heart	NNP
cord-019001-ralxw4ad	524	76	and	and	CC
cord-019001-ralxw4ad	524	77	Lung	Lung	NNP
cord-019001-ralxw4ad	524	78	Transplantation	transplantation	NN
cord-019001-ralxw4ad	524	79	:	:	:
cord-019001-ralxw4ad	525	1	seventh	seventh	JJ
cord-019001-ralxw4ad	525	2	offi	offi	NNP
cord-019001-ralxw4ad	525	3	cial	cial	JJ
cord-019001-ralxw4ad	525	4	pediatric	pediatric	NNP
cord-019001-ralxw4ad	525	5	report-2004	report-2004	NNP
cord-019001-ralxw4ad	525	6	Reversal	reversal	NN
cord-019001-ralxw4ad	525	7	of	of	IN
cord-019001-ralxw4ad	525	8	high	high	JJ
cord-019001-ralxw4ad	525	9	altitude	altitude	NN
cord-019001-ralxw4ad	525	10	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	525	11	hypertension	hypertension	NN
cord-019001-ralxw4ad	526	1	Lung	lung	NN
cord-019001-ralxw4ad	526	2	vascular	vascular	JJ
cord-019001-ralxw4ad	526	3	smooth	smooth	JJ
cord-019001-ralxw4ad	526	4	muscle	muscle	NN
cord-019001-ralxw4ad	526	5	as	as	IN
cord-019001-ralxw4ad	526	6	a	a	DT
cord-019001-ralxw4ad	526	7	determinant	determinant	NN
cord-019001-ralxw4ad	526	8	of	of	IN
cord-019001-ralxw4ad	526	9	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	526	10	hypertension	hypertension	NN
cord-019001-ralxw4ad	526	11	at	at	IN
cord-019001-ralxw4ad	526	12	high	high	JJ
cord-019001-ralxw4ad	526	13	altitude	altitude	NN
cord-019001-ralxw4ad	527	1	Endothelial	endothelial	JJ
cord-019001-ralxw4ad	527	2	and	and	CC
cord-019001-ralxw4ad	527	3	subintimal	subintimal	JJ
cord-019001-ralxw4ad	527	4	changes	change	NNS
cord-019001-ralxw4ad	527	5	in	in	IN
cord-019001-ralxw4ad	527	6	rat	rat	NN
cord-019001-ralxw4ad	527	7	hilar	hilar	JJ
cord-019001-ralxw4ad	527	8	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	527	9	artery	artery	NN
cord-019001-ralxw4ad	527	10	during	during	IN
cord-019001-ralxw4ad	527	11	recovery	recovery	NN
cord-019001-ralxw4ad	527	12	from	from	IN
cord-019001-ralxw4ad	527	13	hypoxia	hypoxia	NN
cord-019001-ralxw4ad	527	14	.	.	.
cord-019001-ralxw4ad	528	1	A	a	DT
cord-019001-ralxw4ad	528	2	quantitative	quantitative	JJ
cord-019001-ralxw4ad	528	3	ultrastructural	ultrastructural	JJ
cord-019001-ralxw4ad	528	4	study	study	NN
cord-019001-ralxw4ad	528	5	Abnormal	abnormal	JJ
cord-019001-ralxw4ad	528	6	circulatory	circulatory	JJ
cord-019001-ralxw4ad	528	7	responses	response	NNS
cord-019001-ralxw4ad	528	8	to	to	IN
cord-019001-ralxw4ad	528	9	high	high	JJ
cord-019001-ralxw4ad	528	10	altitude	altitude	NN
cord-019001-ralxw4ad	528	11	in	in	IN
cord-019001-ralxw4ad	528	12	subjects	subject	NNS
cord-019001-ralxw4ad	528	13	with	with	IN
cord-019001-ralxw4ad	528	14	a	a	DT
cord-019001-ralxw4ad	528	15	previous	previous	JJ
cord-019001-ralxw4ad	528	16	history	history	NN
cord-019001-ralxw4ad	528	17	of	of	IN
cord-019001-ralxw4ad	528	18	high	high	JJ
cord-019001-ralxw4ad	528	19	-	-	HYPH
cord-019001-ralxw4ad	528	20	altitude	altitude	NN
cord-019001-ralxw4ad	528	21	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	528	22	edema	edema	NN
cord-019001-ralxw4ad	528	23	Association	Association	NNP
cord-019001-ralxw4ad	528	24	of	of	IN
cord-019001-ralxw4ad	528	25	high	high	JJ
cord-019001-ralxw4ad	528	26	-	-	HYPH
cord-019001-ralxw4ad	528	27	altitude	altitude	NN
cord-019001-ralxw4ad	528	28	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	528	29	edema	edema	NN
cord-019001-ralxw4ad	528	30	with	with	IN
cord-019001-ralxw4ad	528	31	the	the	DT
cord-019001-ralxw4ad	528	32	major	major	JJ
cord-019001-ralxw4ad	528	33	histocompatibility	histocompatibility	NN
cord-019001-ralxw4ad	528	34	complex	complex	JJ
cord-019001-ralxw4ad	528	35	Oxygen	oxygen	NN
cord-019001-ralxw4ad	528	36	causes	cause	VBZ
cord-019001-ralxw4ad	528	37	fetal	fetal	JJ
cord-019001-ralxw4ad	528	38	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	528	39	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	528	40	through	through	IN
cord-019001-ralxw4ad	528	41	activation	activation	NN
cord-019001-ralxw4ad	528	42	of	of	IN
cord-019001-ralxw4ad	528	43	a	a	DT
cord-019001-ralxw4ad	528	44	calciumdependent	calciumdependent	NN
cord-019001-ralxw4ad	528	45	potassium	potassium	NN
cord-019001-ralxw4ad	528	46	channel	channel	NN
cord-019001-ralxw4ad	528	47	Isolated	isolate	VBN
cord-019001-ralxw4ad	528	48	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	528	49	resistance	resistance	NN
cord-019001-ralxw4ad	528	50	vessels	vessel	NNS
cord-019001-ralxw4ad	528	51	from	from	IN
cord-019001-ralxw4ad	528	52	fetal	fetal	JJ
cord-019001-ralxw4ad	528	53	lambs	lamb	NNS
cord-019001-ralxw4ad	528	54	.	.	.
cord-019001-ralxw4ad	529	1	Contractile	Contractile	NNP
cord-019001-ralxw4ad	529	2	behavior	behavior	NN
cord-019001-ralxw4ad	529	3	and	and	CC
cord-019001-ralxw4ad	529	4	responses	response	NNS
cord-019001-ralxw4ad	529	5	to	to	IN
cord-019001-ralxw4ad	529	6	indomethacin	indomethacin	NN
cord-019001-ralxw4ad	529	7	and	and	CC
cord-019001-ralxw4ad	529	8	endothelin-1	endothelin-1	NNP
cord-019001-ralxw4ad	530	1	Endothelin	Endothelin	NNP
cord-019001-ralxw4ad	530	2	A	a	DT
cord-019001-ralxw4ad	530	3	receptor	receptor	NN
cord-019001-ralxw4ad	530	4	blockade	blockade	NN
cord-019001-ralxw4ad	530	5	decreases	decrease	VBZ
cord-019001-ralxw4ad	530	6	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	530	7	vascular	vascular	JJ
cord-019001-ralxw4ad	530	8	resistance	resistance	NN
cord-019001-ralxw4ad	530	9	in	in	IN
cord-019001-ralxw4ad	530	10	premature	premature	JJ
cord-019001-ralxw4ad	530	11	lambs	lamb	NNS
cord-019001-ralxw4ad	530	12	with	with	IN
cord-019001-ralxw4ad	530	13	hyaline	hyaline	JJ
cord-019001-ralxw4ad	530	14	membrane	membrane	NN
cord-019001-ralxw4ad	530	15	disease	disease	NN
cord-019001-ralxw4ad	530	16	K+	K+	NNP
cord-019001-ralxw4ad	530	17	channel	channel	NN
cord-019001-ralxw4ad	530	18	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	530	19	vasodilation	vasodilation	NN
cord-019001-ralxw4ad	530	20	in	in	IN
cord-019001-ralxw4ad	530	21	fetal	fetal	JJ
cord-019001-ralxw4ad	530	22	lambs	lamb	NNS
cord-019001-ralxw4ad	530	23	:	:	:
cord-019001-ralxw4ad	530	24	role	role	NN
cord-019001-ralxw4ad	530	25	of	of	IN
cord-019001-ralxw4ad	530	26	endothelium	endothelium	NN
cord-019001-ralxw4ad	530	27	-	-	HYPH
cord-019001-ralxw4ad	530	28	derived	derive	VBN
cord-019001-ralxw4ad	530	29	nitric	nitric	NN
cord-019001-ralxw4ad	530	30	oxide	oxide	NN
cord-019001-ralxw4ad	531	1	The	the	DT
cord-019001-ralxw4ad	531	2	acute	acute	JJ
cord-019001-ralxw4ad	531	3	respiratory	respiratory	JJ
cord-019001-ralxw4ad	531	4	distress	distress	NN
cord-019001-ralxw4ad	531	5	syndrome	syndrome	NN
cord-019001-ralxw4ad	531	6	Pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	531	7	hypertension	hypertension	NN
cord-019001-ralxw4ad	531	8	in	in	IN
cord-019001-ralxw4ad	531	9	severe	severe	JJ
cord-019001-ralxw4ad	531	10	acute	acute	JJ
cord-019001-ralxw4ad	531	11	respiratory	respiratory	JJ
cord-019001-ralxw4ad	531	12	failure	failure	NN
cord-019001-ralxw4ad	532	1	The	the	DT
cord-019001-ralxw4ad	532	2	pulmonary	pulmonary	JJ
cord-019001-ralxw4ad	532	3	vascular	vascular	JJ
cord-019001-ralxw4ad	532	4	lesions	lesion	NNS
cord-019001-ralxw4ad	532	5	of	of	IN
cord-019001-ralxw4ad	532	6	the	the	DT
cord-019001-ralxw4ad	532	7	adult	adult	NN
cord-019001-ralxw4ad	532	8	respiratory	respiratory	JJ
cord-019001-ralxw4ad	532	9	distress	distress	NN
cord-019001-ralxw4ad	532	10	syndrome	syndrome	NN
cord-019001-ralxw4ad	532	11	Effect	effect	NN
cord-019001-ralxw4ad	532	12	of	of	IN
cord-019001-ralxw4ad	532	13	increased	increase	VBN
cord-019001-ralxw4ad	532	14	vascular	vascular	JJ
cord-019001-ralxw4ad	532	15	pressure	pressure	NN
cord-019001-ralxw4ad	532	16	on	on	IN
cord-019001-ralxw4ad	532	17	lung	lung	NN
cord-019001-ralxw4ad	532	18	fl	fl	NNP
cord-019001-ralxw4ad	532	19	uid	uid	NN
cord-019001-ralxw4ad	532	20	balance	balance	NN
cord-019001-ralxw4ad	532	21	in	in	IN
cord-019001-ralxw4ad	532	22	unanesthetized	unanesthetized	JJ
cord-019001-ralxw4ad	532	23	sheep	sheep	NN
cord-019001-ralxw4ad	532	24	Biventricular	Biventricular	NNP
cord-019001-ralxw4ad	532	25	function	function	NN
cord-019001-ralxw4ad	532	26	in	in	IN
cord-019001-ralxw4ad	532	27	the	the	DT
cord-019001-ralxw4ad	532	28	adult	adult	NN
cord-019001-ralxw4ad	532	29	respiratory	respiratory	JJ
cord-019001-ralxw4ad	532	30	distress	distress	NN
cord-019001-ralxw4ad	532	31	syndrome	syndrome	NN
cord-019001-ralxw4ad	532	32	Cardiopulmonary	cardiopulmonary	JJ
cord-019001-ralxw4ad	532	33	abnormalities	abnormality	NNS
cord-019001-ralxw4ad	532	34	in	in	IN
cord-019001-ralxw4ad	532	35	severe	severe	JJ
cord-019001-ralxw4ad	532	36	acute	acute	JJ
cord-019001-ralxw4ad	532	37	respiratory	respiratory	JJ
cord-019001-ralxw4ad	532	38	failure	failure	NN
cord-019001-ralxw4ad	533	1	Inhaled	inhale	VBN
cord-019001-ralxw4ad	533	2	nitric	nitric	NN
cord-019001-ralxw4ad	533	3	oxide	oxide	NN
cord-019001-ralxw4ad	533	4	for	for	IN
cord-019001-ralxw4ad	534	1	the	the	DT
cord-019001-ralxw4ad	534	2	adult	adult	NN
cord-019001-ralxw4ad	534	3	respiratory	respiratory	JJ
cord-019001-ralxw4ad	534	4	distress	distress	NN
cord-019001-ralxw4ad	534	5	syndrome	syndrome	NN
cord-019001-ralxw4ad	534	6	Acute	acute	NN
cord-019001-ralxw4ad	534	7	and	and	CC
cord-019001-ralxw4ad	534	8	sustained	sustained	JJ
cord-019001-ralxw4ad	534	9	effects	effect	NNS
cord-019001-ralxw4ad	534	10	of	of	IN
cord-019001-ralxw4ad	534	11	early	early	JJ
cord-019001-ralxw4ad	534	12	administration	administration	NN
cord-019001-ralxw4ad	534	13	of	of	IN
cord-019001-ralxw4ad	534	14	inhaled	inhale	VBN
cord-019001-ralxw4ad	534	15	nitric	nitric	NN
cord-019001-ralxw4ad	534	16	oxide	oxide	NN
cord-019001-ralxw4ad	534	17	to	to	IN
cord-019001-ralxw4ad	534	18	children	child	NNS
cord-019001-ralxw4ad	534	19	with	with	IN
cord-019001-ralxw4ad	534	20	acute	acute	JJ
cord-019001-ralxw4ad	534	21	respiratory	respiratory	JJ
cord-019001-ralxw4ad	534	22	distress	distress	NN
cord-019001-ralxw4ad	534	23	syndrome	syndrome	NN
cord-019001-ralxw4ad	534	24	Low	low	JJ
cord-019001-ralxw4ad	534	25	-	-	HYPH
cord-019001-ralxw4ad	534	26	dose	dose	NN
cord-019001-ralxw4ad	534	27	inhaled	inhale	VBN
cord-019001-ralxw4ad	534	28	nitric	nitric	JJ
cord-019001-ralxw4ad	534	29	oxide	oxide	NN
cord-019001-ralxw4ad	534	30	in	in	IN
cord-019001-ralxw4ad	534	31	patients	patient	NNS
cord-019001-ralxw4ad	534	32	with	with	IN
cord-019001-ralxw4ad	534	33	acute	acute	JJ
cord-019001-ralxw4ad	534	34	lung	lung	NN
cord-019001-ralxw4ad	534	35	injury	injury	NN
cord-019001-ralxw4ad	534	36	:	:	:
cord-019001-ralxw4ad	534	37	a	a	DT
cord-019001-ralxw4ad	534	38	randomized	randomized	JJ
cord-019001-ralxw4ad	534	39	controlled	control	VBN
cord-019001-ralxw4ad	534	40	trial	trial	NN
cord-019001-ralxw4ad	534	41	Inhalation	inhalation	NN
cord-019001-ralxw4ad	534	42	of	of	IN
cord-019001-ralxw4ad	534	43	nitric	nitric	NN
cord-019001-ralxw4ad	534	44	oxide	oxide	NN
cord-019001-ralxw4ad	534	45	in	in	IN
cord-019001-ralxw4ad	534	46	acute	acute	JJ
cord-019001-ralxw4ad	534	47	lung	lung	NN
cord-019001-ralxw4ad	534	48	injury	injury	NN
cord-019001-ralxw4ad	534	49	:	:	:
cord-019001-ralxw4ad	534	50	results	result	NNS
cord-019001-ralxw4ad	534	51	of	of	IN
cord-019001-ralxw4ad	534	52	a	a	DT
cord-019001-ralxw4ad	534	53	European	european	JJ
cord-019001-ralxw4ad	534	54	multicentre	multicentre	NNP
cord-019001-ralxw4ad	534	55	study	study	NN
cord-019001-ralxw4ad	534	56	.	.	.
cord-019001-ralxw4ad	535	1	The	the	DT
cord-019001-ralxw4ad	535	2	European	European	NNP
cord-019001-ralxw4ad	535	3	Study	Study	NNP
cord-019001-ralxw4ad	535	4	Group	Group	NNP
cord-019001-ralxw4ad	535	5	of	of	IN
cord-019001-ralxw4ad	535	6	Inhaled	Inhaled	NNP
cord-019001-ralxw4ad	535	7	Nitric	Nitric	NNP
cord-019001-ralxw4ad	535	8	Oxide	Oxide	NNP