id sid tid token lemma pos cord-320959-sgdqhtns 1 1 key key NNP cord-320959-sgdqhtns 1 2 : : : cord-320959-sgdqhtns 1 3 cord-320959-sgdqhtns cord-320959-sgdqhtns . cord-320959-sgdqhtns 2 1 authors author NNS cord-320959-sgdqhtns 2 2 : : : cord-320959-sgdqhtns 2 3 Lee Lee NNP cord-320959-sgdqhtns 2 4 , , , cord-320959-sgdqhtns 2 5 Hanjun Hanjun NNP cord-320959-sgdqhtns 2 6 title title NN cord-320959-sgdqhtns 2 7 : : : cord-320959-sgdqhtns 2 8 Vitamin vitamin NN cord-320959-sgdqhtns 2 9 E e NN cord-320959-sgdqhtns 2 10 Acetate acetate NN cord-320959-sgdqhtns 2 11 as as IN cord-320959-sgdqhtns 2 12 Linactant Linactant NNP cord-320959-sgdqhtns 2 13 in in IN cord-320959-sgdqhtns 2 14 the the DT cord-320959-sgdqhtns 2 15 Pathophysiology Pathophysiology NNP cord-320959-sgdqhtns 2 16 of of IN cord-320959-sgdqhtns 2 17 EVALI EVALI NNP cord-320959-sgdqhtns 2 18 date date NN cord-320959-sgdqhtns 2 19 : : : cord-320959-sgdqhtns 2 20 2020 2020 CD cord-320959-sgdqhtns 2 21 - - HYPH cord-320959-sgdqhtns 2 22 08 08 CD cord-320959-sgdqhtns 2 23 - - SYM cord-320959-sgdqhtns 2 24 12 12 CD cord-320959-sgdqhtns 2 25 journal journal NN cord-320959-sgdqhtns 2 26 : : : cord-320959-sgdqhtns 3 1 Med Med NNP cord-320959-sgdqhtns 3 2 Hypotheses Hypotheses NNP cord-320959-sgdqhtns 3 3 DOI DOI NNP cord-320959-sgdqhtns 3 4 : : : cord-320959-sgdqhtns 3 5 10.1016/ 10.1016/ CD cord-320959-sgdqhtns 4 1 j.mehy.2020.110182 j.mehy.2020.110182 NNP cord-320959-sgdqhtns 5 1 sha sha NNP cord-320959-sgdqhtns 5 2 : : : cord-320959-sgdqhtns 6 1 a7357414796d0867ef46a83f2c75e0b2aa0f42b1 a7357414796d0867ef46a83f2c75e0b2aa0f42b1 NNP cord-320959-sgdqhtns 6 2 doc_id doc_id NNP cord-320959-sgdqhtns 6 3 : : : cord-320959-sgdqhtns 6 4 320959 320959 CD cord-320959-sgdqhtns 6 5 cord_uid cord_uid NNS cord-320959-sgdqhtns 6 6 : : : cord-320959-sgdqhtns 7 1 sgdqhtns sgdqhtn NNS cord-320959-sgdqhtns 8 1 The the DT cord-320959-sgdqhtns 8 2 recent recent JJ cord-320959-sgdqhtns 8 3 identification identification NN cord-320959-sgdqhtns 8 4 of of IN cord-320959-sgdqhtns 8 5 Vitamin vitamin NN cord-320959-sgdqhtns 8 6 E e NN cord-320959-sgdqhtns 8 7 acetate acetate NN cord-320959-sgdqhtns 8 8 as as IN cord-320959-sgdqhtns 8 9 one one CD cord-320959-sgdqhtns 8 10 of of IN cord-320959-sgdqhtns 8 11 the the DT cord-320959-sgdqhtns 8 12 causal causal JJ cord-320959-sgdqhtns 8 13 agents agent NNS cord-320959-sgdqhtns 8 14 for for IN cord-320959-sgdqhtns 8 15 the the DT cord-320959-sgdqhtns 8 16 e e NN cord-320959-sgdqhtns 8 17 - - NN cord-320959-sgdqhtns 8 18 cigarette cigarette NN cord-320959-sgdqhtns 8 19 , , , cord-320959-sgdqhtns 8 20 or or CC cord-320959-sgdqhtns 8 21 vaping vaping NN cord-320959-sgdqhtns 8 22 , , , cord-320959-sgdqhtns 8 23 product product NN cord-320959-sgdqhtns 8 24 use use NN cord-320959-sgdqhtns 8 25 associated associate VBN cord-320959-sgdqhtns 8 26 lung lung NN cord-320959-sgdqhtns 8 27 injury injury NN cord-320959-sgdqhtns 8 28 ( ( -LRB- cord-320959-sgdqhtns 8 29 EVALI EVALI NNP cord-320959-sgdqhtns 8 30 ) ) -RRB- cord-320959-sgdqhtns 8 31 is be VBZ cord-320959-sgdqhtns 8 32 a a DT cord-320959-sgdqhtns 8 33 major major JJ cord-320959-sgdqhtns 8 34 milestone milestone NN cord-320959-sgdqhtns 8 35 . . . cord-320959-sgdqhtns 9 1 In in IN cord-320959-sgdqhtns 9 2 membrane membrane NN cord-320959-sgdqhtns 9 3 biophysics biophysic NNS cord-320959-sgdqhtns 9 4 , , , cord-320959-sgdqhtns 9 5 Vitamin vitamin NN cord-320959-sgdqhtns 9 6 E e NN cord-320959-sgdqhtns 9 7 is be VBZ cord-320959-sgdqhtns 9 8 a a DT cord-320959-sgdqhtns 9 9 linactant linactant NN cord-320959-sgdqhtns 9 10 and and CC cord-320959-sgdqhtns 9 11 a a DT cord-320959-sgdqhtns 9 12 potent potent JJ cord-320959-sgdqhtns 9 13 modulator modulator NN cord-320959-sgdqhtns 9 14 of of IN cord-320959-sgdqhtns 9 15 lateral lateral JJ cord-320959-sgdqhtns 9 16 phase phase NN cord-320959-sgdqhtns 9 17 separation separation NN cord-320959-sgdqhtns 9 18 that that WDT cord-320959-sgdqhtns 9 19 effectively effectively RB cord-320959-sgdqhtns 9 20 reduces reduce VBZ cord-320959-sgdqhtns 9 21 the the DT cord-320959-sgdqhtns 9 22 line line NN cord-320959-sgdqhtns 9 23 tension tension NN cord-320959-sgdqhtns 9 24 at at IN cord-320959-sgdqhtns 9 25 the the DT cord-320959-sgdqhtns 9 26 two two CD cord-320959-sgdqhtns 9 27 - - HYPH cord-320959-sgdqhtns 9 28 dimensional dimensional JJ cord-320959-sgdqhtns 9 29 phase phase NN cord-320959-sgdqhtns 9 30 boundaries boundary NNS cord-320959-sgdqhtns 9 31 and and CC cord-320959-sgdqhtns 9 32 thereby thereby RB cord-320959-sgdqhtns 9 33 exponentially exponentially RB cord-320959-sgdqhtns 9 34 increases increase VBZ cord-320959-sgdqhtns 9 35 the the DT cord-320959-sgdqhtns 9 36 surface surface NN cord-320959-sgdqhtns 9 37 viscosity viscosity NN cord-320959-sgdqhtns 9 38 of of IN cord-320959-sgdqhtns 9 39 the the DT cord-320959-sgdqhtns 9 40 pulmonary pulmonary JJ cord-320959-sgdqhtns 9 41 surfactant surfactant NN cord-320959-sgdqhtns 9 42 . . . cord-320959-sgdqhtns 10 1 Disrupted disrupt VBN cord-320959-sgdqhtns 10 2 dynamics dynamic NNS cord-320959-sgdqhtns 10 3 of of IN cord-320959-sgdqhtns 10 4 respiratory respiratory JJ cord-320959-sgdqhtns 10 5 compression compression NN cord-320959-sgdqhtns 10 6 - - HYPH cord-320959-sgdqhtns 10 7 expansion expansion NN cord-320959-sgdqhtns 10 8 cycling cycling NN cord-320959-sgdqhtns 10 9 may may MD cord-320959-sgdqhtns 10 10 result result VB cord-320959-sgdqhtns 10 11 in in IN cord-320959-sgdqhtns 10 12 an an DT cord-320959-sgdqhtns 10 13 extensive extensive JJ cord-320959-sgdqhtns 10 14 hypoxemia hypoxemia NN cord-320959-sgdqhtns 10 15 , , , cord-320959-sgdqhtns 10 16 leading lead VBG cord-320959-sgdqhtns 10 17 to to IN cord-320959-sgdqhtns 10 18 an an DT cord-320959-sgdqhtns 10 19 acute acute JJ cord-320959-sgdqhtns 10 20 respiratory respiratory JJ cord-320959-sgdqhtns 10 21 distress distress NN cord-320959-sgdqhtns 10 22 entailing entail VBG cord-320959-sgdqhtns 10 23 the the DT cord-320959-sgdqhtns 10 24 formation formation NN cord-320959-sgdqhtns 10 25 of of IN cord-320959-sgdqhtns 10 26 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 10 27 lipid lipid NN cord-320959-sgdqhtns 10 28 - - HYPH cord-320959-sgdqhtns 10 29 laden laden JJ cord-320959-sgdqhtns 10 30 macrophages macrophage NNS cord-320959-sgdqhtns 10 31 . . . cord-320959-sgdqhtns 11 1 Supplementation supplementation NN cord-320959-sgdqhtns 11 2 of of IN cord-320959-sgdqhtns 11 3 pulmonary pulmonary JJ cord-320959-sgdqhtns 11 4 surfactants surfactant NNS cord-320959-sgdqhtns 11 5 which which WDT cord-320959-sgdqhtns 11 6 retain retain VBP cord-320959-sgdqhtns 11 7 moderate moderate JJ cord-320959-sgdqhtns 11 8 level level NN cord-320959-sgdqhtns 11 9 of of IN cord-320959-sgdqhtns 11 10 cholesterol cholesterol NN cord-320959-sgdqhtns 11 11 and and CC cord-320959-sgdqhtns 11 12 controlled control VBN cord-320959-sgdqhtns 11 13 hypothermia hypothermia NN cord-320959-sgdqhtns 11 14 for for IN cord-320959-sgdqhtns 11 15 patients patient NNS cord-320959-sgdqhtns 11 16 are be VBP cord-320959-sgdqhtns 11 17 recommended recommend VBN cord-320959-sgdqhtns 11 18 when when WRB cord-320959-sgdqhtns 11 19 the the DT cord-320959-sgdqhtns 11 20 hypothesis hypothesis NN cord-320959-sgdqhtns 11 21 that that IN cord-320959-sgdqhtns 11 22 the the DT cord-320959-sgdqhtns 11 23 line line NN cord-320959-sgdqhtns 11 24 - - HYPH cord-320959-sgdqhtns 11 25 active active JJ cord-320959-sgdqhtns 11 26 property property NN cord-320959-sgdqhtns 11 27 of of IN cord-320959-sgdqhtns 11 28 the the DT cord-320959-sgdqhtns 11 29 vitamin vitamin NN cord-320959-sgdqhtns 11 30 derivative derivative JJ cord-320959-sgdqhtns 11 31 drives drive VBZ cord-320959-sgdqhtns 11 32 the the DT cord-320959-sgdqhtns 11 33 pathogenesis pathogenesis NN cord-320959-sgdqhtns 11 34 of of IN cord-320959-sgdqhtns 11 35 EVALI EVALI NNS cord-320959-sgdqhtns 11 36 holds hold VBZ cord-320959-sgdqhtns 11 37 . . . cord-320959-sgdqhtns 12 1 effectively effectively RB cord-320959-sgdqhtns 12 2 reduces reduce VBZ cord-320959-sgdqhtns 12 3 the the DT cord-320959-sgdqhtns 12 4 line line NN cord-320959-sgdqhtns 12 5 tension tension NN cord-320959-sgdqhtns 12 6 at at IN cord-320959-sgdqhtns 12 7 the the DT cord-320959-sgdqhtns 12 8 two two CD cord-320959-sgdqhtns 12 9 - - HYPH cord-320959-sgdqhtns 12 10 dimensional dimensional JJ cord-320959-sgdqhtns 12 11 phase phase NN cord-320959-sgdqhtns 12 12 boundaries boundary NNS cord-320959-sgdqhtns 12 13 and and CC cord-320959-sgdqhtns 12 14 thereby thereby RB cord-320959-sgdqhtns 12 15 exponentially exponentially RB cord-320959-sgdqhtns 12 16 increases increase VBZ cord-320959-sgdqhtns 12 17 the the DT cord-320959-sgdqhtns 12 18 surface surface NN cord-320959-sgdqhtns 12 19 viscosity viscosity NN cord-320959-sgdqhtns 12 20 of of IN cord-320959-sgdqhtns 12 21 the the DT cord-320959-sgdqhtns 12 22 pulmonary pulmonary JJ cord-320959-sgdqhtns 12 23 surfactant surfactant NN cord-320959-sgdqhtns 12 24 . . . cord-320959-sgdqhtns 13 1 Disrupted disrupt VBN cord-320959-sgdqhtns 13 2 dynamics dynamic NNS cord-320959-sgdqhtns 13 3 of of IN cord-320959-sgdqhtns 13 4 respiratory respiratory JJ cord-320959-sgdqhtns 13 5 compression compression NN cord-320959-sgdqhtns 13 6 - - HYPH cord-320959-sgdqhtns 13 7 expansion expansion NN cord-320959-sgdqhtns 13 8 cycling cycling NN cord-320959-sgdqhtns 13 9 may may MD cord-320959-sgdqhtns 13 10 result result VB cord-320959-sgdqhtns 13 11 in in IN cord-320959-sgdqhtns 13 12 an an DT cord-320959-sgdqhtns 13 13 extensive extensive JJ cord-320959-sgdqhtns 13 14 hypoxemia hypoxemia NN cord-320959-sgdqhtns 13 15 , , , cord-320959-sgdqhtns 13 16 leading lead VBG cord-320959-sgdqhtns 13 17 to to IN cord-320959-sgdqhtns 13 18 an an DT cord-320959-sgdqhtns 13 19 acute acute JJ cord-320959-sgdqhtns 13 20 respiratory respiratory JJ cord-320959-sgdqhtns 13 21 distress distress NN cord-320959-sgdqhtns 13 22 entailing entail VBG cord-320959-sgdqhtns 13 23 the the DT cord-320959-sgdqhtns 13 24 formation formation NN cord-320959-sgdqhtns 13 25 of of IN cord-320959-sgdqhtns 13 26 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 13 27 lipid lipid NN cord-320959-sgdqhtns 13 28 - - HYPH cord-320959-sgdqhtns 13 29 laden laden JJ cord-320959-sgdqhtns 13 30 macrophages macrophage NNS cord-320959-sgdqhtns 13 31 . . . cord-320959-sgdqhtns 14 1 Supplementation supplementation NN cord-320959-sgdqhtns 14 2 of of IN cord-320959-sgdqhtns 14 3 pulmonary pulmonary JJ cord-320959-sgdqhtns 14 4 surfactants surfactant NNS cord-320959-sgdqhtns 14 5 which which WDT cord-320959-sgdqhtns 14 6 retain retain VBP cord-320959-sgdqhtns 14 7 moderate moderate JJ cord-320959-sgdqhtns 14 8 level level NN cord-320959-sgdqhtns 14 9 of of IN cord-320959-sgdqhtns 14 10 cholesterol cholesterol NN cord-320959-sgdqhtns 14 11 and and CC cord-320959-sgdqhtns 14 12 10 10 CD cord-320959-sgdqhtns 14 13 controlled control VBN cord-320959-sgdqhtns 14 14 hypothermia hypothermia NN cord-320959-sgdqhtns 14 15 for for IN cord-320959-sgdqhtns 14 16 patients patient NNS cord-320959-sgdqhtns 14 17 are be VBP cord-320959-sgdqhtns 14 18 recommended recommend VBN cord-320959-sgdqhtns 14 19 when when WRB cord-320959-sgdqhtns 14 20 the the DT cord-320959-sgdqhtns 14 21 hypothesis hypothesis NN cord-320959-sgdqhtns 14 22 that that IN cord-320959-sgdqhtns 14 23 the the DT cord-320959-sgdqhtns 14 24 line line NN cord-320959-sgdqhtns 14 25 - - HYPH cord-320959-sgdqhtns 14 26 active active JJ cord-320959-sgdqhtns 14 27 property property NN cord-320959-sgdqhtns 14 28 of of IN cord-320959-sgdqhtns 14 29 the the DT cord-320959-sgdqhtns 14 30 vitamin vitamin NN cord-320959-sgdqhtns 14 31 derivative derivative JJ cord-320959-sgdqhtns 14 32 drives drive VBZ cord-320959-sgdqhtns 14 33 the the DT cord-320959-sgdqhtns 14 34 pathogenesis pathogenesis NN cord-320959-sgdqhtns 14 35 of of IN cord-320959-sgdqhtns 14 36 EVALI EVALI NNS cord-320959-sgdqhtns 14 37 holds hold VBZ cord-320959-sgdqhtns 14 38 . . . cord-320959-sgdqhtns 15 1 As as IN cord-320959-sgdqhtns 15 2 of of IN cord-320959-sgdqhtns 15 3 January January NNP cord-320959-sgdqhtns 15 4 14 14 CD cord-320959-sgdqhtns 15 5 , , , cord-320959-sgdqhtns 15 6 2020 2020 CD cord-320959-sgdqhtns 15 7 , , , cord-320959-sgdqhtns 15 8 there there EX cord-320959-sgdqhtns 15 9 were be VBD cord-320959-sgdqhtns 15 10 2,668 2,668 CD cord-320959-sgdqhtns 15 11 reported report VBN cord-320959-sgdqhtns 15 12 hospitalized hospitalize VBN cord-320959-sgdqhtns 15 13 cases case NNS cord-320959-sgdqhtns 15 14 of of IN cord-320959-sgdqhtns 15 15 e e NN cord-320959-sgdqhtns 15 16 - - NN cord-320959-sgdqhtns 15 17 cigarette cigarette NN cord-320959-sgdqhtns 15 18 , , , cord-320959-sgdqhtns 15 19 or or CC cord-320959-sgdqhtns 15 20 vaping vaping NN cord-320959-sgdqhtns 16 1 , , , cord-320959-sgdqhtns 16 2 product product NN cord-320959-sgdqhtns 16 3 use use NN cord-320959-sgdqhtns 16 4 associated associate VBN cord-320959-sgdqhtns 16 5 lung lung NN cord-320959-sgdqhtns 16 6 injury injury NN cord-320959-sgdqhtns 16 7 ( ( -LRB- cord-320959-sgdqhtns 16 8 EVALI EVALI NNP cord-320959-sgdqhtns 16 9 ) ) -RRB- cord-320959-sgdqhtns 16 10 in in IN cord-320959-sgdqhtns 16 11 the the DT cord-320959-sgdqhtns 16 12 United United NNP cord-320959-sgdqhtns 16 13 States States NNP cord-320959-sgdqhtns 16 14 [ [ -LRB- cord-320959-sgdqhtns 16 15 1 1 CD cord-320959-sgdqhtns 16 16 ] ] -RRB- cord-320959-sgdqhtns 16 17 . . . cord-320959-sgdqhtns 17 1 Patients patient NNS cord-320959-sgdqhtns 17 2 with with IN cord-320959-sgdqhtns 17 3 EVALI EVALI NNS cord-320959-sgdqhtns 17 4 typically typically RB cord-320959-sgdqhtns 17 5 exhibit exhibit VBP cord-320959-sgdqhtns 17 6 respiratory respiratory JJ cord-320959-sgdqhtns 17 7 symptoms symptom NNS cord-320959-sgdqhtns 17 8 , , , cord-320959-sgdqhtns 17 9 such such JJ cord-320959-sgdqhtns 17 10 as as IN cord-320959-sgdqhtns 17 11 dyspnea dyspnea NN cord-320959-sgdqhtns 17 12 and and CC cord-320959-sgdqhtns 17 13 tachypnea tachypnea NNP cord-320959-sgdqhtns 17 14 , , , cord-320959-sgdqhtns 17 15 and and CC cord-320959-sgdqhtns 17 16 often often RB cord-320959-sgdqhtns 17 17 require require VBP cord-320959-sgdqhtns 17 18 the the DT cord-320959-sgdqhtns 17 19 5 5 CD cord-320959-sgdqhtns 17 20 receipt receipt NN cord-320959-sgdqhtns 17 21 of of IN cord-320959-sgdqhtns 17 22 supplemental supplemental JJ cord-320959-sgdqhtns 17 23 oxygen oxygen NN cord-320959-sgdqhtns 17 24 due due IN cord-320959-sgdqhtns 17 25 to to IN cord-320959-sgdqhtns 17 26 progressive progressive JJ cord-320959-sgdqhtns 17 27 hypoxemia hypoxemia NN cord-320959-sgdqhtns 17 28 [ [ -LRB- cord-320959-sgdqhtns 17 29 2 2 CD cord-320959-sgdqhtns 17 30 , , , cord-320959-sgdqhtns 17 31 3 3 CD cord-320959-sgdqhtns 17 32 ] ] -RRB- cord-320959-sgdqhtns 17 33 . . . cord-320959-sgdqhtns 18 1 Computed compute VBN cord-320959-sgdqhtns 18 2 tomography tomography NN cord-320959-sgdqhtns 18 3 ( ( -LRB- cord-320959-sgdqhtns 18 4 CT CT NNP cord-320959-sgdqhtns 18 5 ) ) -RRB- cord-320959-sgdqhtns 18 6 scans scan NNS cord-320959-sgdqhtns 18 7 of of IN cord-320959-sgdqhtns 18 8 the the DT cord-320959-sgdqhtns 18 9 chest chest NN cord-320959-sgdqhtns 18 10 of of IN cord-320959-sgdqhtns 18 11 these these DT cord-320959-sgdqhtns 18 12 patients patient NNS cord-320959-sgdqhtns 18 13 mostly mostly RB cord-320959-sgdqhtns 18 14 display display VBP cord-320959-sgdqhtns 18 15 diffuse diffuse JJ cord-320959-sgdqhtns 18 16 ground ground NN cord-320959-sgdqhtns 18 17 - - HYPH cord-320959-sgdqhtns 18 18 glass glass NN cord-320959-sgdqhtns 18 19 opacity opacity NN cord-320959-sgdqhtns 18 20 , , , cord-320959-sgdqhtns 18 21 a a DT cord-320959-sgdqhtns 18 22 non non JJ cord-320959-sgdqhtns 18 23 - - JJ cord-320959-sgdqhtns 18 24 specific specific JJ cord-320959-sgdqhtns 18 25 sign sign NN cord-320959-sgdqhtns 18 26 characteristic characteristic NN cord-320959-sgdqhtns 18 27 of of IN cord-320959-sgdqhtns 18 28 lung lung NN cord-320959-sgdqhtns 18 29 injury injury NN cord-320959-sgdqhtns 18 30 that that WDT cord-320959-sgdqhtns 18 31 is be VBZ cord-320959-sgdqhtns 18 32 often often RB cord-320959-sgdqhtns 18 33 indistinguishable indistinguishable JJ cord-320959-sgdqhtns 18 34 from from IN cord-320959-sgdqhtns 18 35 those those DT cord-320959-sgdqhtns 18 36 induced induce VBN cord-320959-sgdqhtns 18 37 by by IN cord-320959-sgdqhtns 18 38 viral viral JJ cord-320959-sgdqhtns 18 39 infections infection NNS cord-320959-sgdqhtns 18 40 [ [ -LRB- cord-320959-sgdqhtns 18 41 4 4 CD cord-320959-sgdqhtns 18 42 ] ] -RRB- cord-320959-sgdqhtns 18 43 . . . cord-320959-sgdqhtns 19 1 Extensive extensive JJ cord-320959-sgdqhtns 19 2 investigation investigation NN cord-320959-sgdqhtns 19 3 into into IN cord-320959-sgdqhtns 19 4 EVALI EVALI NNP cord-320959-sgdqhtns 19 5 has have VBZ cord-320959-sgdqhtns 19 6 revealed reveal VBN cord-320959-sgdqhtns 19 7 an an DT cord-320959-sgdqhtns 19 8 emerging emerge VBG cord-320959-sgdqhtns 19 9 link link NN cord-320959-sgdqhtns 19 10 between between IN cord-320959-sgdqhtns 19 11 the the DT cord-320959-sgdqhtns 19 12 disease disease NN cord-320959-sgdqhtns 19 13 and and CC cord-320959-sgdqhtns 19 14 tetrahydrocannabinol tetrahydrocannabinol NN cord-320959-sgdqhtns 19 15 ( ( -LRB- cord-320959-sgdqhtns 19 16 THC THC NNP cord-320959-sgdqhtns 19 17 ) ) -RRB- cord-320959-sgdqhtns 19 18 . . . cord-320959-sgdqhtns 20 1 Reportedly reportedly RB cord-320959-sgdqhtns 20 2 , , , cord-320959-sgdqhtns 20 3 as as RB cord-320959-sgdqhtns 20 4 many many JJ cord-320959-sgdqhtns 20 5 as as IN cord-320959-sgdqhtns 20 6 82 82 CD cord-320959-sgdqhtns 20 7 % % NN cord-320959-sgdqhtns 20 8 of of IN cord-320959-sgdqhtns 20 9 patients patient NNS cord-320959-sgdqhtns 20 10 with with IN cord-320959-sgdqhtns 20 11 EVALI EVALI NNP cord-320959-sgdqhtns 20 12 10 10 CD cord-320959-sgdqhtns 20 13 used use VBN cord-320959-sgdqhtns 20 14 THC thc NN cord-320959-sgdqhtns 20 15 - - HYPH cord-320959-sgdqhtns 20 16 containing contain VBG cord-320959-sgdqhtns 20 17 e e NN cord-320959-sgdqhtns 20 18 - - NNS cord-320959-sgdqhtns 20 19 cigarettes cigarette NNS cord-320959-sgdqhtns 20 20 , , , cord-320959-sgdqhtns 20 21 while while IN cord-320959-sgdqhtns 20 22 those those DT cord-320959-sgdqhtns 20 23 who who WP cord-320959-sgdqhtns 20 24 solely solely RB cord-320959-sgdqhtns 20 25 used use VBD cord-320959-sgdqhtns 20 26 nicotine nicotine NN cord-320959-sgdqhtns 20 27 - - HYPH cord-320959-sgdqhtns 20 28 containing contain VBG cord-320959-sgdqhtns 20 29 products product NNS cord-320959-sgdqhtns 20 30 accounted account VBD cord-320959-sgdqhtns 20 31 for for IN cord-320959-sgdqhtns 20 32 a a DT cord-320959-sgdqhtns 20 33 mere mere JJ cord-320959-sgdqhtns 20 34 14 14 CD cord-320959-sgdqhtns 20 35 % % NN cord-320959-sgdqhtns 20 36 of of IN cord-320959-sgdqhtns 20 37 all all DT cord-320959-sgdqhtns 20 38 cases case NNS cord-320959-sgdqhtns 20 39 [ [ -LRB- cord-320959-sgdqhtns 20 40 1 1 CD cord-320959-sgdqhtns 20 41 ] ] -RRB- cord-320959-sgdqhtns 20 42 . . . cord-320959-sgdqhtns 21 1 Correspondingly correspondingly RB cord-320959-sgdqhtns 21 2 , , , cord-320959-sgdqhtns 21 3 on on IN cord-320959-sgdqhtns 21 4 October October NNP cord-320959-sgdqhtns 21 5 4 4 CD cord-320959-sgdqhtns 21 6 , , , cord-320959-sgdqhtns 21 7 2019 2019 CD cord-320959-sgdqhtns 21 8 , , , cord-320959-sgdqhtns 21 9 the the DT cord-320959-sgdqhtns 21 10 Food Food NNP cord-320959-sgdqhtns 21 11 and and CC cord-320959-sgdqhtns 21 12 Drug Drug NNP cord-320959-sgdqhtns 21 13 Administration Administration NNP cord-320959-sgdqhtns 21 14 issued issue VBD cord-320959-sgdqhtns 21 15 a a DT cord-320959-sgdqhtns 21 16 public public JJ cord-320959-sgdqhtns 21 17 warning warning NN cord-320959-sgdqhtns 21 18 against against IN cord-320959-sgdqhtns 21 19 THC thc NN cord-320959-sgdqhtns 21 20 - - HYPH cord-320959-sgdqhtns 21 21 containing contain VBG cord-320959-sgdqhtns 21 22 vaping vaping NN cord-320959-sgdqhtns 21 23 products product NNS cord-320959-sgdqhtns 21 24 , , , cord-320959-sgdqhtns 21 25 and and CC cord-320959-sgdqhtns 21 26 the the DT cord-320959-sgdqhtns 21 27 rate rate NN cord-320959-sgdqhtns 21 28 of of IN cord-320959-sgdqhtns 21 29 emergency emergency NN cord-320959-sgdqhtns 21 30 department department NN cord-320959-sgdqhtns 21 31 ( ( -LRB- cord-320959-sgdqhtns 21 32 ED ED NNP cord-320959-sgdqhtns 21 33 ) ) -RRB- cord-320959-sgdqhtns 21 34 visits visit NNS cord-320959-sgdqhtns 21 35 due due JJ cord-320959-sgdqhtns 21 36 to to IN cord-320959-sgdqhtns 21 37 EVALI EVALI NNP cord-320959-sgdqhtns 21 38 has have VBZ cord-320959-sgdqhtns 21 39 significantly significantly RB cord-320959-sgdqhtns 21 40 declined decline VBN cord-320959-sgdqhtns 21 41 since since IN cord-320959-sgdqhtns 21 42 then then RB cord-320959-sgdqhtns 21 43 [ [ -LRB- cord-320959-sgdqhtns 21 44 5 5 CD cord-320959-sgdqhtns 21 45 ] ] -RRB- cord-320959-sgdqhtns 21 46 . . . cord-320959-sgdqhtns 22 1 The the DT cord-320959-sgdqhtns 22 2 pathophysiology pathophysiology NN cord-320959-sgdqhtns 22 3 and and CC cord-320959-sgdqhtns 22 4 the the DT cord-320959-sgdqhtns 22 5 definitive definitive JJ cord-320959-sgdqhtns 22 6 cause cause NN cord-320959-sgdqhtns 22 7 of of IN cord-320959-sgdqhtns 22 8 EVALI EVALI NNS cord-320959-sgdqhtns 22 9 are be VBP cord-320959-sgdqhtns 22 10 yet yet RB cord-320959-sgdqhtns 22 11 to to TO cord-320959-sgdqhtns 22 12 be be VB cord-320959-sgdqhtns 22 13 established establish VBN cord-320959-sgdqhtns 22 14 . . . cord-320959-sgdqhtns 23 1 Initial initial JJ cord-320959-sgdqhtns 23 2 efforts effort NNS cord-320959-sgdqhtns 23 3 15 15 CD cord-320959-sgdqhtns 23 4 to to TO cord-320959-sgdqhtns 23 5 elucidate elucidate VB cord-320959-sgdqhtns 23 6 the the DT cord-320959-sgdqhtns 23 7 pathophysiology pathophysiology NN cord-320959-sgdqhtns 23 8 of of IN cord-320959-sgdqhtns 23 9 the the DT cord-320959-sgdqhtns 23 10 disease disease NN cord-320959-sgdqhtns 23 11 have have VBP cord-320959-sgdqhtns 23 12 mainly mainly RB cord-320959-sgdqhtns 23 13 focused focus VBN cord-320959-sgdqhtns 23 14 on on IN cord-320959-sgdqhtns 23 15 its -PRON- PRP$ cord-320959-sgdqhtns 23 16 association association NN cord-320959-sgdqhtns 23 17 with with IN cord-320959-sgdqhtns 23 18 THC THC NNP cord-320959-sgdqhtns 23 19 . . . cord-320959-sgdqhtns 24 1 4 4 CD cord-320959-sgdqhtns 24 2 providers provider NNS cord-320959-sgdqhtns 24 3 still still RB cord-320959-sgdqhtns 24 4 mostly mostly RB cord-320959-sgdqhtns 24 5 rely rely VBP cord-320959-sgdqhtns 24 6 on on IN cord-320959-sgdqhtns 24 7 a a DT cord-320959-sgdqhtns 24 8 diagnosis diagnosis NN cord-320959-sgdqhtns 24 9 of of IN cord-320959-sgdqhtns 24 10 exclusion exclusion NN cord-320959-sgdqhtns 24 11 when when WRB cord-320959-sgdqhtns 24 12 a a DT cord-320959-sgdqhtns 24 13 patient patient NN cord-320959-sgdqhtns 24 14 with with IN cord-320959-sgdqhtns 24 15 a a DT cord-320959-sgdqhtns 24 16 history history NN cord-320959-sgdqhtns 24 17 of of IN cord-320959-sgdqhtns 24 18 THCcontaining thccontaine VBG cord-320959-sgdqhtns 24 19 vaping vape VBG cord-320959-sgdqhtns 24 20 product product NN cord-320959-sgdqhtns 24 21 usage usage NN cord-320959-sgdqhtns 24 22 exhibits exhibit VBZ cord-320959-sgdqhtns 24 23 severe severe JJ cord-320959-sgdqhtns 24 24 respiratory respiratory JJ cord-320959-sgdqhtns 24 25 symptoms symptom NNS cord-320959-sgdqhtns 24 26 indicative indicative JJ cord-320959-sgdqhtns 24 27 of of IN cord-320959-sgdqhtns 24 28 EVALI EVALI NNP cord-320959-sgdqhtns 24 29 [ [ -LRB- cord-320959-sgdqhtns 24 30 3 3 CD cord-320959-sgdqhtns 24 31 ] ] -RRB- cord-320959-sgdqhtns 24 32 . . . cord-320959-sgdqhtns 25 1 Since since IN cord-320959-sgdqhtns 25 2 the the DT cord-320959-sgdqhtns 25 3 epidemic epidemic NN cord-320959-sgdqhtns 25 4 of of IN cord-320959-sgdqhtns 25 5 EVALI EVALI NNP cord-320959-sgdqhtns 25 6 has have VBZ cord-320959-sgdqhtns 25 7 already already RB cord-320959-sgdqhtns 25 8 reached reach VBN cord-320959-sgdqhtns 25 9 its -PRON- PRP$ cord-320959-sgdqhtns 25 10 post post JJ cord-320959-sgdqhtns 25 11 - - JJ cord-320959-sgdqhtns 25 12 peak peak JJ cord-320959-sgdqhtns 25 13 period period NN cord-320959-sgdqhtns 25 14 and and CC cord-320959-sgdqhtns 25 15 is be VBZ cord-320959-sgdqhtns 25 16 expected expect VBN cord-320959-sgdqhtns 25 17 to to TO cord-320959-sgdqhtns 25 18 enter enter VB cord-320959-sgdqhtns 25 19 a a DT cord-320959-sgdqhtns 25 20 post post JJ cord-320959-sgdqhtns 25 21 - - JJ cord-320959-sgdqhtns 25 22 epidemic epidemic JJ cord-320959-sgdqhtns 25 23 one one CD cord-320959-sgdqhtns 25 24 in in IN cord-320959-sgdqhtns 25 25 a a DT cord-320959-sgdqhtns 25 26 near near JJ cord-320959-sgdqhtns 25 27 future future NN cord-320959-sgdqhtns 25 28 [ [ -LRB- cord-320959-sgdqhtns 25 29 5 5 CD cord-320959-sgdqhtns 25 30 ] ] -RRB- cord-320959-sgdqhtns 25 31 , , , cord-320959-sgdqhtns 25 32 thanks thank NNS cord-320959-sgdqhtns 25 33 to to IN cord-320959-sgdqhtns 25 34 global global JJ cord-320959-sgdqhtns 25 35 efforts effort NNS cord-320959-sgdqhtns 25 36 to to TO cord-320959-sgdqhtns 25 37 strengthen strengthen VB cord-320959-sgdqhtns 25 38 regulations regulation NNS cord-320959-sgdqhtns 25 39 against against IN cord-320959-sgdqhtns 25 40 5 5 CD cord-320959-sgdqhtns 25 41 e e NNS cord-320959-sgdqhtns 25 42 - - NNS cord-320959-sgdqhtns 25 43 cigarettes cigarette NNS cord-320959-sgdqhtns 25 44 , , , cord-320959-sgdqhtns 25 45 it -PRON- PRP cord-320959-sgdqhtns 25 46 is be VBZ cord-320959-sgdqhtns 25 47 likely likely JJ cord-320959-sgdqhtns 25 48 that that IN cord-320959-sgdqhtns 25 49 we -PRON- PRP cord-320959-sgdqhtns 25 50 might may MD cord-320959-sgdqhtns 25 51 not not RB cord-320959-sgdqhtns 25 52 be be VB cord-320959-sgdqhtns 25 53 able able JJ cord-320959-sgdqhtns 25 54 to to TO cord-320959-sgdqhtns 25 55 fully fully RB cord-320959-sgdqhtns 25 56 characterize characterize VB cord-320959-sgdqhtns 25 57 the the DT cord-320959-sgdqhtns 25 58 disease disease NN cord-320959-sgdqhtns 25 59 before before IN cord-320959-sgdqhtns 25 60 the the DT cord-320959-sgdqhtns 25 61 epidemic epidemic NN cord-320959-sgdqhtns 25 62 is be VBZ cord-320959-sgdqhtns 25 63 finally finally RB cord-320959-sgdqhtns 25 64 over over RB cord-320959-sgdqhtns 25 65 . . . cord-320959-sgdqhtns 26 1 Nonetheless nonetheless RB cord-320959-sgdqhtns 26 2 , , , cord-320959-sgdqhtns 26 3 for for IN cord-320959-sgdqhtns 26 4 thousands thousand NNS cord-320959-sgdqhtns 26 5 of of IN cord-320959-sgdqhtns 26 6 hospitalized hospitalize VBN cord-320959-sgdqhtns 26 7 patients patient NNS cord-320959-sgdqhtns 26 8 who who WP cord-320959-sgdqhtns 26 9 still still RB cord-320959-sgdqhtns 26 10 suffer suffer VBP cord-320959-sgdqhtns 26 11 from from IN cord-320959-sgdqhtns 26 12 the the DT cord-320959-sgdqhtns 26 13 disorder disorder NN cord-320959-sgdqhtns 26 14 and and CC cord-320959-sgdqhtns 26 15 for for IN cord-320959-sgdqhtns 26 16 the the DT cord-320959-sgdqhtns 26 17 deceased deceased JJ cord-320959-sgdqhtns 26 18 who who WP cord-320959-sgdqhtns 26 19 died die VBD cord-320959-sgdqhtns 26 20 without without IN cord-320959-sgdqhtns 26 21 knowing know VBG cord-320959-sgdqhtns 26 22 what what WP cord-320959-sgdqhtns 26 23 they -PRON- PRP cord-320959-sgdqhtns 26 24 were be VBD cord-320959-sgdqhtns 26 25 exactly exactly RB cord-320959-sgdqhtns 26 26 dying die VBG cord-320959-sgdqhtns 26 27 from from IN cord-320959-sgdqhtns 26 28 , , , cord-320959-sgdqhtns 26 29 the the DT cord-320959-sgdqhtns 26 30 pathophysiological pathophysiological JJ cord-320959-sgdqhtns 26 31 characterization characterization NN cord-320959-sgdqhtns 26 32 of of IN cord-320959-sgdqhtns 26 33 the the DT cord-320959-sgdqhtns 26 34 disease disease NN cord-320959-sgdqhtns 26 35 should should MD cord-320959-sgdqhtns 26 36 be be VB cord-320959-sgdqhtns 26 37 continued continue VBN cord-320959-sgdqhtns 26 38 and and CC cord-320959-sgdqhtns 26 39 recent recent JJ cord-320959-sgdqhtns 26 40 breakthroughs breakthrough NNS cord-320959-sgdqhtns 26 41 in in IN cord-320959-sgdqhtns 26 42 the the DT cord-320959-sgdqhtns 26 43 field field NN cord-320959-sgdqhtns 26 44 are be VBP cord-320959-sgdqhtns 26 45 tremendously tremendously RB cord-320959-sgdqhtns 26 46 supporting support VBG cord-320959-sgdqhtns 26 47 us -PRON- PRP cord-320959-sgdqhtns 26 48 . . . cord-320959-sgdqhtns 27 1 10 10 CD cord-320959-sgdqhtns 28 1 Recently recently RB cord-320959-sgdqhtns 28 2 , , , cord-320959-sgdqhtns 28 3 investigators investigator NNS cord-320959-sgdqhtns 28 4 at at IN cord-320959-sgdqhtns 28 5 the the DT cord-320959-sgdqhtns 28 6 Centers Centers NNPS cord-320959-sgdqhtns 28 7 for for IN cord-320959-sgdqhtns 28 8 Disease Disease NNP cord-320959-sgdqhtns 28 9 Control Control NNP cord-320959-sgdqhtns 28 10 and and CC cord-320959-sgdqhtns 28 11 Prevention Prevention NNP cord-320959-sgdqhtns 28 12 ( ( -LRB- cord-320959-sgdqhtns 28 13 CDC CDC NNP cord-320959-sgdqhtns 28 14 ) ) -RRB- cord-320959-sgdqhtns 28 15 identified identify VBD cord-320959-sgdqhtns 29 1 Vitamin vitamin NN cord-320959-sgdqhtns 29 2 E e NN cord-320959-sgdqhtns 29 3 acetate acetate NN cord-320959-sgdqhtns 29 4 , , , cord-320959-sgdqhtns 29 5 a a DT cord-320959-sgdqhtns 29 6 chemical chemical NN cord-320959-sgdqhtns 29 7 widely widely RB cord-320959-sgdqhtns 29 8 utilized utilize VBN cord-320959-sgdqhtns 29 9 as as IN cord-320959-sgdqhtns 29 10 a a DT cord-320959-sgdqhtns 29 11 diluent diluent NN cord-320959-sgdqhtns 29 12 for for IN cord-320959-sgdqhtns 29 13 THC thc NN cord-320959-sgdqhtns 29 14 - - HYPH cord-320959-sgdqhtns 29 15 containing contain VBG cord-320959-sgdqhtns 29 16 vaping vaping NN cord-320959-sgdqhtns 29 17 fluids fluid NNS cord-320959-sgdqhtns 29 18 , , , cord-320959-sgdqhtns 29 19 as as IN cord-320959-sgdqhtns 29 20 one one CD cord-320959-sgdqhtns 29 21 of of IN cord-320959-sgdqhtns 29 22 the the DT cord-320959-sgdqhtns 29 23 potential potential JJ cord-320959-sgdqhtns 29 24 causal causal JJ cord-320959-sgdqhtns 29 25 agents agent NNS cord-320959-sgdqhtns 29 26 of of IN cord-320959-sgdqhtns 29 27 EVALI EVALI NNP cord-320959-sgdqhtns 29 28 [ [ -LRB- cord-320959-sgdqhtns 29 29 12 12 CD cord-320959-sgdqhtns 29 30 ] ] -RRB- cord-320959-sgdqhtns 29 31 . . . cord-320959-sgdqhtns 30 1 Among among IN cord-320959-sgdqhtns 30 2 51 51 CD cord-320959-sgdqhtns 30 3 submitted submit VBN cord-320959-sgdqhtns 30 4 samples sample NNS cord-320959-sgdqhtns 30 5 of of IN cord-320959-sgdqhtns 30 6 bronchoalveolar bronchoalveolar NNP cord-320959-sgdqhtns 30 7 lavage lavage NNP cord-320959-sgdqhtns 30 8 ( ( -LRB- cord-320959-sgdqhtns 30 9 BAL BAL NNP cord-320959-sgdqhtns 30 10 ) ) -RRB- cord-320959-sgdqhtns 30 11 fluid fluid NN cord-320959-sgdqhtns 30 12 from from IN cord-320959-sgdqhtns 30 13 patients patient NNS cord-320959-sgdqhtns 30 14 , , , cord-320959-sgdqhtns 30 15 48 48 CD cord-320959-sgdqhtns 30 16 samples sample NNS cord-320959-sgdqhtns 30 17 contained contain VBD cord-320959-sgdqhtns 30 18 high high JJ cord-320959-sgdqhtns 30 19 content content NN cord-320959-sgdqhtns 30 20 of of IN cord-320959-sgdqhtns 30 21 Vitamin vitamin NN cord-320959-sgdqhtns 30 22 E e NN cord-320959-sgdqhtns 30 23 acetate acetate NN cord-320959-sgdqhtns 30 24 exceeding exceed VBG cord-320959-sgdqhtns 30 25 2.32 2.32 CD cord-320959-sgdqhtns 30 26 nM nm NN cord-320959-sgdqhtns 30 27 , , , cord-320959-sgdqhtns 30 28 while while IN cord-320959-sgdqhtns 30 29 none none NN cord-320959-sgdqhtns 30 30 was be VBD cord-320959-sgdqhtns 30 31 observed observe VBN cord-320959-sgdqhtns 30 32 in in IN cord-320959-sgdqhtns 30 33 those those DT cord-320959-sgdqhtns 30 34 of of IN cord-320959-sgdqhtns 30 35 healthy healthy JJ cord-320959-sgdqhtns 30 36 e e NN cord-320959-sgdqhtns 30 37 - - NN cord-320959-sgdqhtns 30 38 cigarette cigarette NN cord-320959-sgdqhtns 30 39 users user NNS cord-320959-sgdqhtns 30 40 15 15 CD cord-320959-sgdqhtns 30 41 without without IN cord-320959-sgdqhtns 30 42 EVALI EVALI NNS cord-320959-sgdqhtns 30 43 . . . cord-320959-sgdqhtns 31 1 Primary primary JJ cord-320959-sgdqhtns 31 2 toxicants toxicant NNS cord-320959-sgdqhtns 31 3 other other JJ cord-320959-sgdqhtns 31 4 than than IN cord-320959-sgdqhtns 32 1 Vitamin vitamin NN cord-320959-sgdqhtns 32 2 E e NN cord-320959-sgdqhtns 32 3 acetate acetate NN cord-320959-sgdqhtns 32 4 were be VBD cord-320959-sgdqhtns 32 5 nearly nearly RB cord-320959-sgdqhtns 32 6 absent absent JJ cord-320959-sgdqhtns 32 7 in in IN cord-320959-sgdqhtns 32 8 BAL bal NN cord-320959-sgdqhtns 32 9 fluid fluid NN cord-320959-sgdqhtns 32 10 samples sample NNS cord-320959-sgdqhtns 32 11 from from IN cord-320959-sgdqhtns 32 12 patients patient NNS cord-320959-sgdqhtns 32 13 , , , cord-320959-sgdqhtns 32 14 indicating indicate VBG cord-320959-sgdqhtns 32 15 a a DT cord-320959-sgdqhtns 32 16 strong strong JJ cord-320959-sgdqhtns 32 17 association association NN cord-320959-sgdqhtns 32 18 of of IN cord-320959-sgdqhtns 32 19 Vitamin Vitamin NNP cord-320959-sgdqhtns 32 20 E E NNP cord-320959-sgdqhtns 32 21 acetate acetate NN cord-320959-sgdqhtns 32 22 in in IN cord-320959-sgdqhtns 32 23 the the DT cord-320959-sgdqhtns 32 24 pathology pathology NN cord-320959-sgdqhtns 32 25 . . . cord-320959-sgdqhtns 33 1 In in IN cord-320959-sgdqhtns 33 2 a a DT cord-320959-sgdqhtns 33 3 field field NN cord-320959-sgdqhtns 33 4 predominated predominate VBN cord-320959-sgdqhtns 33 5 by by IN cord-320959-sgdqhtns 33 6 confusion confusion NN cord-320959-sgdqhtns 33 7 , , , cord-320959-sgdqhtns 33 8 this this DT cord-320959-sgdqhtns 33 9 discovery discovery NN cord-320959-sgdqhtns 33 10 sets set VBZ cord-320959-sgdqhtns 33 11 an an DT cord-320959-sgdqhtns 33 12 important important JJ cord-320959-sgdqhtns 33 13 milestone milestone NN cord-320959-sgdqhtns 33 14 . . . cord-320959-sgdqhtns 34 1 Vitamin vitamin NN cord-320959-sgdqhtns 34 2 E e NN cord-320959-sgdqhtns 34 3 has have VBZ cord-320959-sgdqhtns 34 4 long long RB cord-320959-sgdqhtns 34 5 been be VBN cord-320959-sgdqhtns 34 6 thought think VBN cord-320959-sgdqhtns 34 7 of of IN cord-320959-sgdqhtns 34 8 as as IN cord-320959-sgdqhtns 34 9 an an DT cord-320959-sgdqhtns 34 10 antioxidant antioxidant JJ cord-320959-sgdqhtns 34 11 dwelling dwelling NN cord-320959-sgdqhtns 34 12 in in IN cord-320959-sgdqhtns 34 13 the the DT cord-320959-sgdqhtns 34 14 lipid lipid NN cord-320959-sgdqhtns 34 15 bilayer bilayer NN cord-320959-sgdqhtns 34 16 . . . cord-320959-sgdqhtns 35 1 In in IN cord-320959-sgdqhtns 35 2 fact fact NN cord-320959-sgdqhtns 35 3 , , , cord-320959-sgdqhtns 35 4 the the DT cord-320959-sgdqhtns 35 5 discovery discovery NN cord-320959-sgdqhtns 35 6 of of IN cord-320959-sgdqhtns 35 7 the the DT cord-320959-sgdqhtns 35 8 vitamin vitamin NN cord-320959-sgdqhtns 35 9 itself -PRON- PRP cord-320959-sgdqhtns 35 10 has have VBZ cord-320959-sgdqhtns 35 11 come come VBN cord-320959-sgdqhtns 35 12 from from IN cord-320959-sgdqhtns 35 13 reports report NNS cord-320959-sgdqhtns 35 14 of of IN cord-320959-sgdqhtns 35 15 fetal fetal JJ cord-320959-sgdqhtns 35 16 resorption resorption NN cord-320959-sgdqhtns 35 17 in in IN cord-320959-sgdqhtns 35 18 murine murine JJ cord-320959-sgdqhtns 35 19 models model NNS cord-320959-sgdqhtns 35 20 which which WDT cord-320959-sgdqhtns 35 21 were be VBD cord-320959-sgdqhtns 35 22 depleted deplete VBN cord-320959-sgdqhtns 35 23 of of IN cord-320959-sgdqhtns 35 24 the the DT cord-320959-sgdqhtns 35 25 vitamin vitamin NN cord-320959-sgdqhtns 35 26 [ [ -LRB- cord-320959-sgdqhtns 35 27 13 13 CD cord-320959-sgdqhtns 35 28 ] ] -RRB- cord-320959-sgdqhtns 35 29 . . . cord-320959-sgdqhtns 36 1 The the DT cord-320959-sgdqhtns 36 2 lethality lethality NN cord-320959-sgdqhtns 36 3 of of IN cord-320959-sgdqhtns 36 4 Vitamin vitamin NN cord-320959-sgdqhtns 36 5 E e NN cord-320959-sgdqhtns 36 6 deficiency deficiency NN cord-320959-sgdqhtns 36 7 was be VBD cord-320959-sgdqhtns 36 8 later later RB cord-320959-sgdqhtns 36 9 attributed attribute VBN cord-320959-sgdqhtns 36 10 to to IN cord-320959-sgdqhtns 36 11 5 5 CD cord-320959-sgdqhtns 36 12 the the DT cord-320959-sgdqhtns 36 13 lack lack NN cord-320959-sgdqhtns 36 14 of of IN cord-320959-sgdqhtns 36 15 its -PRON- PRP$ cord-320959-sgdqhtns 36 16 antioxidative antioxidative JJ cord-320959-sgdqhtns 36 17 capacities capacity NNS cord-320959-sgdqhtns 36 18 , , , cord-320959-sgdqhtns 36 19 and and CC cord-320959-sgdqhtns 36 20 it -PRON- PRP cord-320959-sgdqhtns 36 21 is be VBZ cord-320959-sgdqhtns 36 22 now now RB cord-320959-sgdqhtns 36 23 well well RB cord-320959-sgdqhtns 36 24 - - HYPH cord-320959-sgdqhtns 36 25 established establish VBN cord-320959-sgdqhtns 36 26 that that IN cord-320959-sgdqhtns 36 27 the the DT cord-320959-sgdqhtns 36 28 vitamin vitamin NN cord-320959-sgdqhtns 36 29 is be VBZ cord-320959-sgdqhtns 36 30 required require VBN cord-320959-sgdqhtns 36 31 for for IN cord-320959-sgdqhtns 36 32 the the DT cord-320959-sgdqhtns 36 33 protection protection NN cord-320959-sgdqhtns 36 34 of of IN cord-320959-sgdqhtns 36 35 polyunsaturated polyunsaturated JJ cord-320959-sgdqhtns 36 36 fatty fatty JJ cord-320959-sgdqhtns 36 37 acids acid NNS cord-320959-sgdqhtns 36 38 from from IN cord-320959-sgdqhtns 36 39 being be VBG cord-320959-sgdqhtns 36 40 unwantedly unwantedly RB cord-320959-sgdqhtns 36 41 oxidized oxidize VBN cord-320959-sgdqhtns 36 42 [ [ -LRB- cord-320959-sgdqhtns 36 43 14 14 CD cord-320959-sgdqhtns 36 44 ] ] -RRB- cord-320959-sgdqhtns 36 45 . . . cord-320959-sgdqhtns 37 1 However however RB cord-320959-sgdqhtns 37 2 , , , cord-320959-sgdqhtns 37 3 Vitamin vitamin NN cord-320959-sgdqhtns 37 4 E e NN cord-320959-sgdqhtns 37 5 acetate acetate NN cord-320959-sgdqhtns 37 6 , , , cord-320959-sgdqhtns 37 7 given give VBN cord-320959-sgdqhtns 37 8 the the DT cord-320959-sgdqhtns 37 9 additional additional JJ cord-320959-sgdqhtns 37 10 ester ester NN cord-320959-sgdqhtns 37 11 moiety moiety NN cord-320959-sgdqhtns 37 12 , , , cord-320959-sgdqhtns 37 13 is be VBZ cord-320959-sgdqhtns 37 14 deprived deprive VBN cord-320959-sgdqhtns 37 15 of of IN cord-320959-sgdqhtns 37 16 the the DT cord-320959-sgdqhtns 37 17 antioxidative antioxidative JJ cord-320959-sgdqhtns 37 18 property property NN cord-320959-sgdqhtns 37 19 and and CC cord-320959-sgdqhtns 37 20 is be VBZ cord-320959-sgdqhtns 37 21 markedly markedly RB cord-320959-sgdqhtns 37 22 more more RBR cord-320959-sgdqhtns 37 23 thermostable thermostable JJ cord-320959-sgdqhtns 37 24 . . . cord-320959-sgdqhtns 38 1 Furthermore furthermore RB cord-320959-sgdqhtns 38 2 , , , cord-320959-sgdqhtns 38 3 its -PRON- PRP$ cord-320959-sgdqhtns 38 4 affinity affinity NN cord-320959-sgdqhtns 38 5 to to IN cord-320959-sgdqhtns 38 6 α α NN cord-320959-sgdqhtns 38 7 - - HYPH cord-320959-sgdqhtns 38 8 tocopherol tocopherol NN cord-320959-sgdqhtns 38 9 transfer transfer NN cord-320959-sgdqhtns 38 10 protein protein NN cord-320959-sgdqhtns 38 11 ( ( -LRB- cord-320959-sgdqhtns 38 12 αTTP αttp NN cord-320959-sgdqhtns 38 13 ) ) -RRB- cord-320959-sgdqhtns 38 14 is be VBZ cord-320959-sgdqhtns 38 15 ~50-fold ~50-fold JJ cord-320959-sgdqhtns 38 16 lower low JJR cord-320959-sgdqhtns 38 17 than than IN cord-320959-sgdqhtns 38 18 that that DT cord-320959-sgdqhtns 38 19 of of IN cord-320959-sgdqhtns 38 20 the the DT cord-320959-sgdqhtns 38 21 natural natural JJ cord-320959-sgdqhtns 38 22 stereoisomer stereoisomer NN cord-320959-sgdqhtns 38 23 of of IN cord-320959-sgdqhtns 38 24 Vitamin vitamin NN cord-320959-sgdqhtns 38 25 E e NN cord-320959-sgdqhtns 38 26 [ [ -LRB- cord-320959-sgdqhtns 38 27 15 15 CD cord-320959-sgdqhtns 38 28 ] ] -RRB- cord-320959-sgdqhtns 38 29 , , , cord-320959-sgdqhtns 38 30 indicating indicate VBG cord-320959-sgdqhtns 38 31 the the DT cord-320959-sgdqhtns 38 32 10 10 CD cord-320959-sgdqhtns 38 33 significance significance NN cord-320959-sgdqhtns 38 34 of of IN cord-320959-sgdqhtns 38 35 an an DT cord-320959-sgdqhtns 38 36 extensive extensive JJ cord-320959-sgdqhtns 38 37 water water NN cord-320959-sgdqhtns 38 38 bridge bridge NN cord-320959-sgdqhtns 38 39 between between IN cord-320959-sgdqhtns 38 40 the the DT cord-320959-sgdqhtns 38 41 hydroxyl hydroxyl NN cord-320959-sgdqhtns 38 42 group group NN cord-320959-sgdqhtns 38 43 and and CC cord-320959-sgdqhtns 38 44 residues residue NNS cord-320959-sgdqhtns 38 45 Tyr117 tyr117 CD cord-320959-sgdqhtns 38 46 , , , cord-320959-sgdqhtns 38 47 Ser136 ser136 CD cord-320959-sgdqhtns 38 48 , , , cord-320959-sgdqhtns 38 49 and and CC cord-320959-sgdqhtns 38 50 Ser140 ser140 CD cord-320959-sgdqhtns 38 51 in in IN cord-320959-sgdqhtns 38 52 the the DT cord-320959-sgdqhtns 38 53 binding binding NN cord-320959-sgdqhtns 38 54 of of IN cord-320959-sgdqhtns 38 55 the the DT cord-320959-sgdqhtns 38 56 vitamin vitamin NN cord-320959-sgdqhtns 38 57 to to IN cord-320959-sgdqhtns 38 58 αTTP αttp CD cord-320959-sgdqhtns 38 59 [ [ -LRB- cord-320959-sgdqhtns 38 60 16 16 CD cord-320959-sgdqhtns 38 61 ] ] -RRB- cord-320959-sgdqhtns 38 62 . . . cord-320959-sgdqhtns 39 1 Despite despite IN cord-320959-sgdqhtns 39 2 αTTP αttp CD cord-320959-sgdqhtns 39 3 often often RB cord-320959-sgdqhtns 39 4 being be VBG cord-320959-sgdqhtns 39 5 recognized recognize VBN cord-320959-sgdqhtns 39 6 as as IN cord-320959-sgdqhtns 39 7 a a DT cord-320959-sgdqhtns 39 8 hepatocyte hepatocyte NN cord-320959-sgdqhtns 39 9 - - HYPH cord-320959-sgdqhtns 39 10 specific specific JJ cord-320959-sgdqhtns 39 11 protein protein NN cord-320959-sgdqhtns 39 12 which which WDT cord-320959-sgdqhtns 39 13 presents present VBZ cord-320959-sgdqhtns 39 14 Vitamin vitamin NN cord-320959-sgdqhtns 39 15 E e NN cord-320959-sgdqhtns 39 16 from from IN cord-320959-sgdqhtns 39 17 endosomal endosomal NNP cord-320959-sgdqhtns 39 18 compartments compartment NNS cord-320959-sgdqhtns 39 19 to to IN cord-320959-sgdqhtns 39 20 the the DT cord-320959-sgdqhtns 39 21 plasma plasma NN cord-320959-sgdqhtns 39 22 membrane membrane NN cord-320959-sgdqhtns 39 23 for for IN cord-320959-sgdqhtns 39 24 secretion secretion NN cord-320959-sgdqhtns 39 25 [ [ -LRB- cord-320959-sgdqhtns 39 26 17 17 CD cord-320959-sgdqhtns 39 27 ] ] -RRB- cord-320959-sgdqhtns 39 28 , , , cord-320959-sgdqhtns 39 29 it -PRON- PRP cord-320959-sgdqhtns 39 30 is be VBZ cord-320959-sgdqhtns 39 31 also also RB cord-320959-sgdqhtns 39 32 expressed express VBN cord-320959-sgdqhtns 39 33 in in IN cord-320959-sgdqhtns 39 34 the the DT cord-320959-sgdqhtns 39 35 lung lung NN cord-320959-sgdqhtns 39 36 where where WRB cord-320959-sgdqhtns 39 37 it -PRON- PRP cord-320959-sgdqhtns 39 38 non non JJ cord-320959-sgdqhtns 39 39 - - JJ cord-320959-sgdqhtns 39 40 canonically canonically RB cord-320959-sgdqhtns 39 41 increases increase VBZ cord-320959-sgdqhtns 39 42 the the DT cord-320959-sgdqhtns 39 43 level level NN cord-320959-sgdqhtns 39 44 of of IN cord-320959-sgdqhtns 39 45 Vitamin vitamin NN cord-320959-sgdqhtns 39 46 E e NN cord-320959-sgdqhtns 39 47 upon upon IN cord-320959-sgdqhtns 39 48 hypercapnia hypercapnia NN cord-320959-sgdqhtns 39 49 [ [ -LRB- cord-320959-sgdqhtns 39 50 18 18 CD cord-320959-sgdqhtns 39 51 ] ] -RRB- cord-320959-sgdqhtns 39 52 . . . cord-320959-sgdqhtns 40 1 Due due IN cord-320959-sgdqhtns 40 2 to to IN cord-320959-sgdqhtns 40 3 these these DT cord-320959-sgdqhtns 40 4 significant significant JJ cord-320959-sgdqhtns 40 5 15 15 CD cord-320959-sgdqhtns 40 6 differences difference NNS cord-320959-sgdqhtns 40 7 between between IN cord-320959-sgdqhtns 40 8 Vitamin vitamin NN cord-320959-sgdqhtns 40 9 E e NN cord-320959-sgdqhtns 40 10 and and CC cord-320959-sgdqhtns 40 11 Vitamin vitamin NN cord-320959-sgdqhtns 40 12 E e NN cord-320959-sgdqhtns 40 13 acetate acetate NN cord-320959-sgdqhtns 40 14 , , , cord-320959-sgdqhtns 40 15 it -PRON- PRP cord-320959-sgdqhtns 40 16 is be VBZ cord-320959-sgdqhtns 40 17 important important JJ cord-320959-sgdqhtns 40 18 to to TO cord-320959-sgdqhtns 40 19 clarify clarify VB cord-320959-sgdqhtns 40 20 whether whether IN cord-320959-sgdqhtns 40 21 the the DT cord-320959-sgdqhtns 40 22 lung lung NN cord-320959-sgdqhtns 40 23 injury injury NN cord-320959-sgdqhtns 40 24 observed observe VBD cord-320959-sgdqhtns 40 25 in in IN cord-320959-sgdqhtns 40 26 patients patient NNS cord-320959-sgdqhtns 40 27 with with IN cord-320959-sgdqhtns 40 28 EVALI EVALI NNS cord-320959-sgdqhtns 40 29 is be VBZ cord-320959-sgdqhtns 40 30 induced induce VBN cord-320959-sgdqhtns 40 31 solely solely RB cord-320959-sgdqhtns 40 32 by by IN cord-320959-sgdqhtns 40 33 the the DT cord-320959-sgdqhtns 40 34 esterified esterify VBN cord-320959-sgdqhtns 40 35 derivative derivative NN cord-320959-sgdqhtns 40 36 of of IN cord-320959-sgdqhtns 40 37 the the DT cord-320959-sgdqhtns 40 38 vitamin vitamin NN cord-320959-sgdqhtns 40 39 . . . cord-320959-sgdqhtns 41 1 Unfortunately unfortunately RB cord-320959-sgdqhtns 41 2 , , , cord-320959-sgdqhtns 41 3 the the DT cord-320959-sgdqhtns 41 4 distinguishment distinguishment NN cord-320959-sgdqhtns 41 5 between between IN cord-320959-sgdqhtns 41 6 the the DT cord-320959-sgdqhtns 41 7 two two CD cord-320959-sgdqhtns 41 8 compounds compound NNS cord-320959-sgdqhtns 41 9 has have VBZ cord-320959-sgdqhtns 41 10 largely largely RB cord-320959-sgdqhtns 41 11 been be VBN cord-320959-sgdqhtns 41 12 neglected neglect VBN cord-320959-sgdqhtns 41 13 in in IN cord-320959-sgdqhtns 41 14 the the DT cord-320959-sgdqhtns 41 15 field field NN cord-320959-sgdqhtns 41 16 of of IN cord-320959-sgdqhtns 41 17 EVALI EVALI NNP cord-320959-sgdqhtns 41 18 , , , cord-320959-sgdqhtns 41 19 and and CC cord-320959-sgdqhtns 41 20 the the DT cord-320959-sgdqhtns 41 21 scarcity scarcity NN cord-320959-sgdqhtns 41 22 of of IN cord-320959-sgdqhtns 41 23 information information NN cord-320959-sgdqhtns 41 24 on on IN cord-320959-sgdqhtns 41 25 the the DT cord-320959-sgdqhtns 41 26 esterified esterify VBN cord-320959-sgdqhtns 41 27 derivative derivative NN cord-320959-sgdqhtns 41 28 of of IN cord-320959-sgdqhtns 41 29 the the DT cord-320959-sgdqhtns 41 30 vitamin vitamin NN cord-320959-sgdqhtns 41 31 has have VBZ cord-320959-sgdqhtns 41 32 forced force VBN cord-320959-sgdqhtns 41 33 many many JJ cord-320959-sgdqhtns 41 34 investigators investigator NNS cord-320959-sgdqhtns 41 35 to to TO cord-320959-sgdqhtns 41 36 rely rely VB cord-320959-sgdqhtns 41 37 on on IN cord-320959-sgdqhtns 41 38 reported report VBN cord-320959-sgdqhtns 41 39 biochemical biochemical JJ cord-320959-sgdqhtns 41 40 properties property NNS cord-320959-sgdqhtns 41 41 of of IN cord-320959-sgdqhtns 41 42 20 20 CD cord-320959-sgdqhtns 41 43 unmodified unmodified JJ cord-320959-sgdqhtns 41 44 Vitamin vitamin NN cord-320959-sgdqhtns 41 45 E e NN cord-320959-sgdqhtns 41 46 in in IN cord-320959-sgdqhtns 41 47 elucidating elucidate VBG cord-320959-sgdqhtns 41 48 the the DT cord-320959-sgdqhtns 41 49 pathophysiology pathophysiology NN cord-320959-sgdqhtns 41 50 of of IN cord-320959-sgdqhtns 41 51 EVALI EVALI NNS cord-320959-sgdqhtns 41 52 . . . cord-320959-sgdqhtns 42 1 Unlike unlike IN cord-320959-sgdqhtns 42 2 those those DT cord-320959-sgdqhtns 42 3 administered administer VBN cord-320959-sgdqhtns 42 4 via via IN cord-320959-sgdqhtns 42 5 dietary dietary JJ cord-320959-sgdqhtns 42 6 uptake uptake NN cord-320959-sgdqhtns 42 7 [ [ -LRB- cord-320959-sgdqhtns 42 8 19 19 CD cord-320959-sgdqhtns 42 9 ] ] -RRB- cord-320959-sgdqhtns 42 10 , , , cord-320959-sgdqhtns 42 11 wherein wherein WRB cord-320959-sgdqhtns 42 12 the the DT cord-320959-sgdqhtns 42 13 compound compound NN cord-320959-sgdqhtns 42 14 is be VBZ cord-320959-sgdqhtns 42 15 readily readily RB cord-320959-sgdqhtns 42 16 hydrolyzed hydrolyze VBN cord-320959-sgdqhtns 42 17 by by IN cord-320959-sgdqhtns 42 18 cellular cellular JJ cord-320959-sgdqhtns 42 19 esterases esterase NNS cord-320959-sgdqhtns 42 20 , , , cord-320959-sgdqhtns 42 21 including include VBG cord-320959-sgdqhtns 42 22 pancreatic pancreatic JJ cord-320959-sgdqhtns 42 23 carboxyl carboxyl NN cord-320959-sgdqhtns 42 24 ester ester NN cord-320959-sgdqhtns 42 25 hydrolase hydrolase NNP cord-320959-sgdqhtns 42 26 and and CC cord-320959-sgdqhtns 42 27 cholesteryl cholesteryl NNP cord-320959-sgdqhtns 42 28 ester ester NNP cord-320959-sgdqhtns 42 29 hydrolase hydrolase NNP cord-320959-sgdqhtns 42 30 [ [ -LRB- cord-320959-sgdqhtns 42 31 20 20 CD cord-320959-sgdqhtns 42 32 , , , cord-320959-sgdqhtns 42 33 21 21 CD cord-320959-sgdqhtns 42 34 ] ] -RRB- cord-320959-sgdqhtns 42 35 , , , cord-320959-sgdqhtns 42 36 inhaled inhale VBN cord-320959-sgdqhtns 42 37 Vitamin vitamin NN cord-320959-sgdqhtns 42 38 E e NN cord-320959-sgdqhtns 42 39 acetate acetate NN cord-320959-sgdqhtns 42 40 does do VBZ cord-320959-sgdqhtns 42 41 not not RB cord-320959-sgdqhtns 42 42 undergo undergo VB cord-320959-sgdqhtns 42 43 esterase esterase NN cord-320959-sgdqhtns 42 44 - - HYPH cord-320959-sgdqhtns 42 45 mediated mediate VBN cord-320959-sgdqhtns 42 46 hydrolysis hydrolysis NN cord-320959-sgdqhtns 42 47 in in IN cord-320959-sgdqhtns 42 48 the the DT cord-320959-sgdqhtns 42 49 time time NN cord-320959-sgdqhtns 42 50 scale scale NN cord-320959-sgdqhtns 42 51 of of IN cord-320959-sgdqhtns 42 52 several several JJ cord-320959-sgdqhtns 42 53 hours hour NNS cord-320959-sgdqhtns 42 54 [ [ -LRB- cord-320959-sgdqhtns 42 55 22 22 CD cord-320959-sgdqhtns 42 56 , , , cord-320959-sgdqhtns 42 57 23 23 CD cord-320959-sgdqhtns 42 58 ] ] -RRB- cord-320959-sgdqhtns 42 59 . . . cord-320959-sgdqhtns 43 1 This this DT cord-320959-sgdqhtns 43 2 indicates indicate VBZ cord-320959-sgdqhtns 43 3 that that IN cord-320959-sgdqhtns 43 4 most most JJS cord-320959-sgdqhtns 43 5 of of IN cord-320959-sgdqhtns 43 6 the the DT cord-320959-sgdqhtns 43 7 inhaled inhale VBN cord-320959-sgdqhtns 43 8 Vitamin vitamin NN cord-320959-sgdqhtns 43 9 E e NN cord-320959-sgdqhtns 43 10 acetate acetate NN cord-320959-sgdqhtns 43 11 would would MD cord-320959-sgdqhtns 43 12 remain remain VB cord-320959-sgdqhtns 43 13 unhydrolyzed unhydrolyze VBN cord-320959-sgdqhtns 43 14 in in IN cord-320959-sgdqhtns 43 15 the the DT cord-320959-sgdqhtns 43 16 lung lung NN cord-320959-sgdqhtns 43 17 of of IN cord-320959-sgdqhtns 43 18 e e NN cord-320959-sgdqhtns 43 19 - - NN cord-320959-sgdqhtns 43 20 cigarette cigarette NN cord-320959-sgdqhtns 43 21 users user NNS cord-320959-sgdqhtns 43 22 even even RB cord-320959-sgdqhtns 43 23 until until IN cord-320959-sgdqhtns 43 24 the the DT cord-320959-sgdqhtns 43 25 next next JJ cord-320959-sgdqhtns 43 26 vaping vaping NN cord-320959-sgdqhtns 43 27 session session NN cord-320959-sgdqhtns 43 28 in in IN cord-320959-sgdqhtns 43 29 a a DT cord-320959-sgdqhtns 43 30 typical typical JJ cord-320959-sgdqhtns 43 31 setting setting NN cord-320959-sgdqhtns 43 32 . . . cord-320959-sgdqhtns 44 1 This this DT cord-320959-sgdqhtns 44 2 is be VBZ cord-320959-sgdqhtns 44 3 analogous analogous JJ cord-320959-sgdqhtns 44 4 to to IN cord-320959-sgdqhtns 44 5 those those DT cord-320959-sgdqhtns 44 6 observations observation NNS cord-320959-sgdqhtns 44 7 made make VBN cord-320959-sgdqhtns 44 8 in in IN cord-320959-sgdqhtns 44 9 skin skin NN cord-320959-sgdqhtns 44 10 , , , cord-320959-sgdqhtns 44 11 wherein wherein WRB cord-320959-sgdqhtns 44 12 the the DT cord-320959-sgdqhtns 44 13 hydrolysis hydrolysis NN cord-320959-sgdqhtns 44 14 rate rate NN cord-320959-sgdqhtns 44 15 of of IN cord-320959-sgdqhtns 44 16 the the DT cord-320959-sgdqhtns 44 17 esterified esterified JJ cord-320959-sgdqhtns 44 18 derivative derivative NN cord-320959-sgdqhtns 44 19 was be VBD cord-320959-sgdqhtns 44 20 measured measure VBN cord-320959-sgdqhtns 44 21 as as IN cord-320959-sgdqhtns 44 22 mere mere JJ cord-320959-sgdqhtns 44 23 5 5 CD cord-320959-sgdqhtns 44 24 % % NN cord-320959-sgdqhtns 44 25 [ [ -LRB- cord-320959-sgdqhtns 44 26 24 24 CD cord-320959-sgdqhtns 44 27 ] ] -RRB- cord-320959-sgdqhtns 44 28 . . . cord-320959-sgdqhtns 45 1 The the DT cord-320959-sgdqhtns 45 2 mechanistic mechanistic JJ cord-320959-sgdqhtns 45 3 detail detail NN cord-320959-sgdqhtns 45 4 on on IN cord-320959-sgdqhtns 45 5 why why WRB cord-320959-sgdqhtns 45 6 5 5 CD cord-320959-sgdqhtns 45 7 inhaled inhale VBN cord-320959-sgdqhtns 45 8 Vitamin vitamin NN cord-320959-sgdqhtns 45 9 E e NN cord-320959-sgdqhtns 45 10 acetate acetate NN cord-320959-sgdqhtns 45 11 is be VBZ cord-320959-sgdqhtns 45 12 resistant resistant JJ cord-320959-sgdqhtns 45 13 to to IN cord-320959-sgdqhtns 45 14 esterase esterase NN cord-320959-sgdqhtns 45 15 - - HYPH cord-320959-sgdqhtns 45 16 mediated mediate VBN cord-320959-sgdqhtns 45 17 hydrolysis hydrolysis NN cord-320959-sgdqhtns 45 18 , , , cord-320959-sgdqhtns 45 19 however however RB cord-320959-sgdqhtns 45 20 , , , cord-320959-sgdqhtns 45 21 is be VBZ cord-320959-sgdqhtns 45 22 poorly poorly RB cord-320959-sgdqhtns 45 23 understood understand VBN cord-320959-sgdqhtns 45 24 . . . cord-320959-sgdqhtns 46 1 Despite despite IN cord-320959-sgdqhtns 46 2 the the DT cord-320959-sgdqhtns 46 3 remaining remain VBG cord-320959-sgdqhtns 46 4 controversy controversy NN cord-320959-sgdqhtns 46 5 on on IN cord-320959-sgdqhtns 46 6 which which WDT cord-320959-sgdqhtns 46 7 of of IN cord-320959-sgdqhtns 46 8 these these DT cord-320959-sgdqhtns 46 9 compounds compound NNS cord-320959-sgdqhtns 46 10 is be VBZ cord-320959-sgdqhtns 46 11 responsible responsible JJ cord-320959-sgdqhtns 46 12 for for IN cord-320959-sgdqhtns 46 13 the the DT cord-320959-sgdqhtns 46 14 pathogenesis pathogenesis NN cord-320959-sgdqhtns 46 15 of of IN cord-320959-sgdqhtns 46 16 EVALI EVALI NNS cord-320959-sgdqhtns 46 17 , , , cord-320959-sgdqhtns 46 18 there there EX cord-320959-sgdqhtns 46 19 is be VBZ cord-320959-sgdqhtns 46 20 ample ample JJ cord-320959-sgdqhtns 46 21 amount amount NN cord-320959-sgdqhtns 46 22 of of IN cord-320959-sgdqhtns 46 23 evidence evidence NN cord-320959-sgdqhtns 46 24 to to TO cord-320959-sgdqhtns 46 25 rule rule VB cord-320959-sgdqhtns 46 26 out out RP cord-320959-sgdqhtns 46 27 the the DT cord-320959-sgdqhtns 46 28 antioxidative antioxidative JJ cord-320959-sgdqhtns 46 29 property property NN cord-320959-sgdqhtns 46 30 of of IN cord-320959-sgdqhtns 46 31 Vitamin vitamin NN cord-320959-sgdqhtns 46 32 E e NN cord-320959-sgdqhtns 46 33 as as IN cord-320959-sgdqhtns 46 34 its -PRON- PRP$ cord-320959-sgdqhtns 46 35 driving drive VBG cord-320959-sgdqhtns 46 36 force force NN cord-320959-sgdqhtns 46 37 . . . cord-320959-sgdqhtns 47 1 Antioxidative antioxidative JJ cord-320959-sgdqhtns 47 2 activities activity NNS cord-320959-sgdqhtns 47 3 have have VBP cord-320959-sgdqhtns 47 4 long long RB cord-320959-sgdqhtns 47 5 been be VBN cord-320959-sgdqhtns 47 6 recognized recognize VBN cord-320959-sgdqhtns 47 7 as as IN cord-320959-sgdqhtns 47 8 a a DT cord-320959-sgdqhtns 47 9 10 10 CD cord-320959-sgdqhtns 47 10 protective protective JJ cord-320959-sgdqhtns 47 11 mechanism mechanism NN cord-320959-sgdqhtns 47 12 against against IN cord-320959-sgdqhtns 47 13 injury injury NN cord-320959-sgdqhtns 47 14 in in IN cord-320959-sgdqhtns 47 15 respiratory respiratory JJ cord-320959-sgdqhtns 47 16 disorders disorder NNS cord-320959-sgdqhtns 47 17 . . . cord-320959-sgdqhtns 48 1 Indeed indeed RB cord-320959-sgdqhtns 48 2 , , , cord-320959-sgdqhtns 48 3 pulmonary pulmonary JJ cord-320959-sgdqhtns 48 4 surfactants surfactant NNS cord-320959-sgdqhtns 48 5 contain contain VBP cord-320959-sgdqhtns 48 6 significant significant JJ cord-320959-sgdqhtns 48 7 amounts amount NNS cord-320959-sgdqhtns 48 8 of of IN cord-320959-sgdqhtns 48 9 superoxide superoxide NN cord-320959-sgdqhtns 48 10 dismutase dismutase NN cord-320959-sgdqhtns 48 11 and and CC cord-320959-sgdqhtns 48 12 catalase catalase NN cord-320959-sgdqhtns 48 13 activities activity NNS cord-320959-sgdqhtns 48 14 , , , cord-320959-sgdqhtns 48 15 which which WDT cord-320959-sgdqhtns 48 16 act act VBP cord-320959-sgdqhtns 48 17 to to TO cord-320959-sgdqhtns 48 18 scavenge scavenge VB cord-320959-sgdqhtns 48 19 extracellular extracellular JJ cord-320959-sgdqhtns 48 20 reactive reactive JJ cord-320959-sgdqhtns 48 21 oxygen oxygen NN cord-320959-sgdqhtns 48 22 species specie NNS cord-320959-sgdqhtns 48 23 , , , cord-320959-sgdqhtns 48 24 such such JJ cord-320959-sgdqhtns 48 25 as as IN cord-320959-sgdqhtns 48 26 hydrogen hydrogen NN cord-320959-sgdqhtns 48 27 peroxide peroxide NN cord-320959-sgdqhtns 48 28 , , , cord-320959-sgdqhtns 48 29 within within IN cord-320959-sgdqhtns 48 30 the the DT cord-320959-sgdqhtns 48 31 pulmonary pulmonary JJ cord-320959-sgdqhtns 48 32 system system NN cord-320959-sgdqhtns 48 33 [ [ -LRB- cord-320959-sgdqhtns 48 34 25 25 CD cord-320959-sgdqhtns 48 35 ] ] -RRB- cord-320959-sgdqhtns 48 36 . . . cord-320959-sgdqhtns 49 1 Similarly similarly RB cord-320959-sgdqhtns 49 2 , , , cord-320959-sgdqhtns 49 3 type type NN cord-320959-sgdqhtns 49 4 II ii CD cord-320959-sgdqhtns 49 5 alveolar alveolar NN cord-320959-sgdqhtns 49 6 pneumocytes pneumocyte NNS cord-320959-sgdqhtns 49 7 secrete secrete VBP cord-320959-sgdqhtns 49 8 Vitamin vitamin NN cord-320959-sgdqhtns 49 9 E e NN cord-320959-sgdqhtns 49 10 alongside alongside IN cord-320959-sgdqhtns 49 11 pulmonary pulmonary JJ cord-320959-sgdqhtns 49 12 surfactants surfactant NNS cord-320959-sgdqhtns 49 13 to to TO cord-320959-sgdqhtns 49 14 protect protect VB cord-320959-sgdqhtns 49 15 the the DT cord-320959-sgdqhtns 49 16 respiratory respiratory JJ cord-320959-sgdqhtns 49 17 system system NN cord-320959-sgdqhtns 49 18 against against IN cord-320959-sgdqhtns 49 19 inhaled inhale VBN cord-320959-sgdqhtns 49 20 oxidants oxidant NNS cord-320959-sgdqhtns 49 21 [ [ -LRB- cord-320959-sgdqhtns 49 22 26 26 CD cord-320959-sgdqhtns 49 23 , , , cord-320959-sgdqhtns 49 24 27 27 CD cord-320959-sgdqhtns 49 25 ] ] -RRB- cord-320959-sgdqhtns 49 26 . . . cord-320959-sgdqhtns 50 1 However however RB cord-320959-sgdqhtns 50 2 , , , cord-320959-sgdqhtns 50 3 it -PRON- PRP cord-320959-sgdqhtns 50 4 is be VBZ cord-320959-sgdqhtns 50 5 15 15 CD cord-320959-sgdqhtns 50 6 worth worth JJ cord-320959-sgdqhtns 50 7 to to TO cord-320959-sgdqhtns 50 8 note note VB cord-320959-sgdqhtns 50 9 that that IN cord-320959-sgdqhtns 50 10 the the DT cord-320959-sgdqhtns 50 11 protective protective JJ cord-320959-sgdqhtns 50 12 effect effect NN cord-320959-sgdqhtns 50 13 of of IN cord-320959-sgdqhtns 50 14 Vitamin vitamin NN cord-320959-sgdqhtns 50 15 E e NN cord-320959-sgdqhtns 50 16 in in IN cord-320959-sgdqhtns 50 17 the the DT cord-320959-sgdqhtns 50 18 pulmonary pulmonary JJ cord-320959-sgdqhtns 50 19 system system NN cord-320959-sgdqhtns 50 20 is be VBZ cord-320959-sgdqhtns 50 21 not not RB cord-320959-sgdqhtns 50 22 solely solely RB cord-320959-sgdqhtns 50 23 due due JJ cord-320959-sgdqhtns 50 24 to to IN cord-320959-sgdqhtns 50 25 its -PRON- PRP$ cord-320959-sgdqhtns 50 26 antioxidative antioxidative JJ cord-320959-sgdqhtns 50 27 property property NN cord-320959-sgdqhtns 50 28 . . . cord-320959-sgdqhtns 51 1 Indeed indeed RB cord-320959-sgdqhtns 51 2 , , , cord-320959-sgdqhtns 51 3 the the DT cord-320959-sgdqhtns 51 4 transcriptional transcriptional JJ cord-320959-sgdqhtns 51 5 activation activation NN cord-320959-sgdqhtns 51 6 of of IN cord-320959-sgdqhtns 51 7 αTTP αttp CD cord-320959-sgdqhtns 51 8 , , , cord-320959-sgdqhtns 51 9 which which WDT cord-320959-sgdqhtns 51 10 increases increase VBZ cord-320959-sgdqhtns 51 11 the the DT cord-320959-sgdqhtns 51 12 level level NN cord-320959-sgdqhtns 51 13 of of IN cord-320959-sgdqhtns 51 14 Vitamin vitamin NN cord-320959-sgdqhtns 51 15 E e NN cord-320959-sgdqhtns 51 16 in in IN cord-320959-sgdqhtns 51 17 the the DT cord-320959-sgdqhtns 51 18 pulmonary pulmonary JJ cord-320959-sgdqhtns 51 19 system system NN cord-320959-sgdqhtns 51 20 , , , cord-320959-sgdqhtns 51 21 protects protect VBZ cord-320959-sgdqhtns 51 22 against against IN cord-320959-sgdqhtns 51 23 ventilator ventilator NN cord-320959-sgdqhtns 51 24 - - HYPH cord-320959-sgdqhtns 51 25 induced induce VBN cord-320959-sgdqhtns 51 26 lung lung NN cord-320959-sgdqhtns 51 27 injury injury NN cord-320959-sgdqhtns 51 28 in in IN cord-320959-sgdqhtns 51 29 murine murine JJ cord-320959-sgdqhtns 51 30 models model NNS cord-320959-sgdqhtns 51 31 without without IN cord-320959-sgdqhtns 51 32 affecting affect VBG cord-320959-sgdqhtns 51 33 antioxidant antioxidant JJ cord-320959-sgdqhtns 51 34 response response NN cord-320959-sgdqhtns 51 35 signaling signal VBG cord-320959-sgdqhtns 51 36 , , , cord-320959-sgdqhtns 51 37 such such JJ cord-320959-sgdqhtns 51 38 as as IN cord-320959-sgdqhtns 51 39 those those DT cord-320959-sgdqhtns 51 40 dependent dependent JJ cord-320959-sgdqhtns 51 41 on on IN cord-320959-sgdqhtns 51 42 nuclear nuclear JJ cord-320959-sgdqhtns 51 43 factor factor NN cord-320959-sgdqhtns 51 44 erythroid erythroid NN cord-320959-sgdqhtns 51 45 2-related 2-related CD cord-320959-sgdqhtns 51 46 factor factor NN cord-320959-sgdqhtns 51 47 2 2 CD cord-320959-sgdqhtns 52 1 ( ( -LRB- cord-320959-sgdqhtns 52 2 NRF2 NRF2 NNP cord-320959-sgdqhtns 52 3 ) ) -RRB- cord-320959-sgdqhtns 53 1 [ [ -LRB- cord-320959-sgdqhtns 53 2 18 18 CD cord-320959-sgdqhtns 53 3 ] ] -RRB- cord-320959-sgdqhtns 53 4 . . . cord-320959-sgdqhtns 54 1 20 20 CD cord-320959-sgdqhtns 54 2 Recent recent JJ cord-320959-sgdqhtns 54 3 investigations investigation NNS cord-320959-sgdqhtns 54 4 on on IN cord-320959-sgdqhtns 54 5 the the DT cord-320959-sgdqhtns 54 6 biological biological JJ cord-320959-sgdqhtns 54 7 action action NN cord-320959-sgdqhtns 54 8 of of IN cord-320959-sgdqhtns 54 9 the the DT cord-320959-sgdqhtns 54 10 vitamin vitamin NN cord-320959-sgdqhtns 54 11 have have VBP cord-320959-sgdqhtns 54 12 raised raise VBN cord-320959-sgdqhtns 54 13 an an DT cord-320959-sgdqhtns 54 14 emerging emerge VBG cord-320959-sgdqhtns 54 15 appreciation appreciation NN cord-320959-sgdqhtns 54 16 of of IN cord-320959-sgdqhtns 54 17 its -PRON- PRP$ cord-320959-sgdqhtns 54 18 non non JJ cord-320959-sgdqhtns 54 19 - - JJ cord-320959-sgdqhtns 54 20 antioxidative antioxidative JJ cord-320959-sgdqhtns 54 21 properties property NNS cord-320959-sgdqhtns 54 22 [ [ -LRB- cord-320959-sgdqhtns 54 23 28 28 CD cord-320959-sgdqhtns 54 24 , , , cord-320959-sgdqhtns 54 25 29 29 CD cord-320959-sgdqhtns 54 26 ] ] -RRB- cord-320959-sgdqhtns 54 27 . . . cord-320959-sgdqhtns 55 1 Although although IN cord-320959-sgdqhtns 55 2 it -PRON- PRP cord-320959-sgdqhtns 55 3 remains remain VBZ cord-320959-sgdqhtns 55 4 a a DT cord-320959-sgdqhtns 55 5 matter matter NN cord-320959-sgdqhtns 55 6 of of IN cord-320959-sgdqhtns 55 7 controversy controversy NN cord-320959-sgdqhtns 55 8 whether whether IN cord-320959-sgdqhtns 55 9 non non JJ cord-320959-sgdqhtns 55 10 - - JJ cord-320959-sgdqhtns 55 11 antioxidative antioxidative JJ cord-320959-sgdqhtns 55 12 properties property NNS cord-320959-sgdqhtns 55 13 of of IN cord-320959-sgdqhtns 55 14 the the DT cord-320959-sgdqhtns 55 15 vitamin vitamin NN cord-320959-sgdqhtns 55 16 can can MD cord-320959-sgdqhtns 55 17 be be VB cord-320959-sgdqhtns 55 18 strictly strictly RB cord-320959-sgdqhtns 55 19 discriminated discriminate VBN cord-320959-sgdqhtns 55 20 from from IN cord-320959-sgdqhtns 55 21 its -PRON- PRP$ cord-320959-sgdqhtns 55 22 antioxidative antioxidative JJ cord-320959-sgdqhtns 55 23 property property NN cord-320959-sgdqhtns 55 24 [ [ -LRB- cord-320959-sgdqhtns 55 25 30 30 CD cord-320959-sgdqhtns 55 26 ] ] -RRB- cord-320959-sgdqhtns 55 27 , , , cord-320959-sgdqhtns 55 28 thorough thorough JJ cord-320959-sgdqhtns 55 29 examination examination NN cord-320959-sgdqhtns 55 30 of of IN cord-320959-sgdqhtns 55 31 the the DT cord-320959-sgdqhtns 55 32 effects effect NNS cord-320959-sgdqhtns 55 33 of of IN cord-320959-sgdqhtns 55 34 Vitamin vitamin NN cord-320959-sgdqhtns 55 35 E e NN cord-320959-sgdqhtns 55 36 other other JJ cord-320959-sgdqhtns 55 37 than than IN cord-320959-sgdqhtns 55 38 antioxidation antioxidation NN cord-320959-sgdqhtns 55 39 in in IN cord-320959-sgdqhtns 55 40 this this DT cord-320959-sgdqhtns 55 41 poorly poorly RB cord-320959-sgdqhtns 55 42 characterized characterize VBN cord-320959-sgdqhtns 55 43 respiratory respiratory JJ cord-320959-sgdqhtns 55 44 disorder disorder NN cord-320959-sgdqhtns 55 45 remains remain VBZ cord-320959-sgdqhtns 55 46 valuable valuable JJ cord-320959-sgdqhtns 55 47 . . . cord-320959-sgdqhtns 56 1 In in IN cord-320959-sgdqhtns 56 2 this this DT cord-320959-sgdqhtns 56 3 regard regard NN cord-320959-sgdqhtns 56 4 , , , cord-320959-sgdqhtns 56 5 herein herein RB cord-320959-sgdqhtns 56 6 I -PRON- PRP cord-320959-sgdqhtns 56 7 discuss discuss VBP cord-320959-sgdqhtns 56 8 several several JJ cord-320959-sgdqhtns 56 9 possible possible JJ cord-320959-sgdqhtns 56 10 mechanisms mechanism NNS cord-320959-sgdqhtns 56 11 by by IN cord-320959-sgdqhtns 56 12 which which WDT cord-320959-sgdqhtns 56 13 Vitamin vitamin NN cord-320959-sgdqhtns 56 14 E e NN cord-320959-sgdqhtns 56 15 acetate acetate NN cord-320959-sgdqhtns 56 16 in in IN cord-320959-sgdqhtns 56 17 vaping vape VBG cord-320959-sgdqhtns 56 18 fluids fluid NNS cord-320959-sgdqhtns 56 19 may may MD cord-320959-sgdqhtns 56 20 drive drive VB cord-320959-sgdqhtns 56 21 the the DT cord-320959-sgdqhtns 56 22 pathogenesis pathogenesis NN cord-320959-sgdqhtns 56 23 of of IN cord-320959-sgdqhtns 56 24 EVALI EVALI NNS cord-320959-sgdqhtns 56 25 . . . cord-320959-sgdqhtns 57 1 As as IN cord-320959-sgdqhtns 57 2 the the DT cord-320959-sgdqhtns 57 3 biochemical biochemical JJ cord-320959-sgdqhtns 57 4 properties property NNS cord-320959-sgdqhtns 57 5 of of IN cord-320959-sgdqhtns 57 6 the the DT cord-320959-sgdqhtns 57 7 vitamin vitamin NN cord-320959-sgdqhtns 57 8 derivative derivative NN cord-320959-sgdqhtns 57 9 have have VBP cord-320959-sgdqhtns 57 10 been be VBN cord-320959-sgdqhtns 57 11 insufficiently insufficiently RB cord-320959-sgdqhtns 57 12 characterized characterize VBN cord-320959-sgdqhtns 57 13 , , , cord-320959-sgdqhtns 57 14 I -PRON- PRP cord-320959-sgdqhtns 57 15 focus focus VBP cord-320959-sgdqhtns 57 16 on on IN cord-320959-sgdqhtns 57 17 those those DT cord-320959-sgdqhtns 57 18 of of IN cord-320959-sgdqhtns 57 19 an an DT cord-320959-sgdqhtns 57 20 unmodified unmodified JJ cord-320959-sgdqhtns 57 21 vitamin vitamin NN cord-320959-sgdqhtns 57 22 . . . cord-320959-sgdqhtns 58 1 Currently currently RB cord-320959-sgdqhtns 58 2 , , , cord-320959-sgdqhtns 58 3 there there EX cord-320959-sgdqhtns 58 4 are be VBP cord-320959-sgdqhtns 58 5 5 5 CD cord-320959-sgdqhtns 58 6 five five CD cord-320959-sgdqhtns 58 7 established establish VBN cord-320959-sgdqhtns 58 8 non non JJ cord-320959-sgdqhtns 58 9 - - JJ cord-320959-sgdqhtns 58 10 antioxidative antioxidative JJ cord-320959-sgdqhtns 58 11 properties property NNS cord-320959-sgdqhtns 58 12 of of IN cord-320959-sgdqhtns 58 13 Vitamin vitamin NN cord-320959-sgdqhtns 58 14 E e NN cord-320959-sgdqhtns 58 15 in in IN cord-320959-sgdqhtns 58 16 the the DT cord-320959-sgdqhtns 58 17 biological biological JJ cord-320959-sgdqhtns 58 18 system system NN cord-320959-sgdqhtns 58 19 : : : cord-320959-sgdqhtns 58 20 i i NN cord-320959-sgdqhtns 58 21 ) ) -RRB- cord-320959-sgdqhtns 59 1 its -PRON- PRP$ cord-320959-sgdqhtns 59 2 ability ability NN cord-320959-sgdqhtns 59 3 to to TO cord-320959-sgdqhtns 59 4 induce induce VB cord-320959-sgdqhtns 59 5 gel gel NN cord-320959-sgdqhtns 59 6 - - HYPH cord-320959-sgdqhtns 59 7 liquid liquid NN cord-320959-sgdqhtns 59 8 crystalline crystalline NN cord-320959-sgdqhtns 59 9 phase phase NN cord-320959-sgdqhtns 59 10 transition transition NN cord-320959-sgdqhtns 59 11 , , , cord-320959-sgdqhtns 59 12 ii ii LS cord-320959-sgdqhtns 59 13 ) ) -RRB- cord-320959-sgdqhtns 59 14 its -PRON- PRP$ cord-320959-sgdqhtns 59 15 active active JJ cord-320959-sgdqhtns 59 16 deposition deposition NN cord-320959-sgdqhtns 59 17 in in IN cord-320959-sgdqhtns 59 18 the the DT cord-320959-sgdqhtns 59 19 lipid lipid NN cord-320959-sgdqhtns 59 20 droplet droplet NN cord-320959-sgdqhtns 59 21 of of IN cord-320959-sgdqhtns 59 22 macrophages macrophage NNS cord-320959-sgdqhtns 59 23 , , , cord-320959-sgdqhtns 59 24 iii iii NN cord-320959-sgdqhtns 59 25 ) ) -RRB- cord-320959-sgdqhtns 60 1 its -PRON- PRP$ cord-320959-sgdqhtns 60 2 modulation modulation NN cord-320959-sgdqhtns 60 3 of of IN cord-320959-sgdqhtns 60 4 the the DT cord-320959-sgdqhtns 60 5 antidiabetic antidiabetic JJ cord-320959-sgdqhtns 60 6 cascade cascade NN cord-320959-sgdqhtns 60 7 involving involve VBG cord-320959-sgdqhtns 60 8 diacylglycerol diacylglycerol NN cord-320959-sgdqhtns 60 9 kinase kinase NN cord-320959-sgdqhtns 60 10 ( ( -LRB- cord-320959-sgdqhtns 60 11 DGK DGK NNP cord-320959-sgdqhtns 60 12 ) ) -RRB- cord-320959-sgdqhtns 60 13 and and CC cord-320959-sgdqhtns 60 14 protein protein NN cord-320959-sgdqhtns 60 15 kinase kinase NN cord-320959-sgdqhtns 60 16 C C NNP cord-320959-sgdqhtns 60 17 ( ( -LRB- cord-320959-sgdqhtns 60 18 PKC PKC NNP cord-320959-sgdqhtns 60 19 ) ) -RRB- cord-320959-sgdqhtns 60 20 , , , cord-320959-sgdqhtns 60 21 iv iv LS cord-320959-sgdqhtns 60 22 ) ) -RRB- cord-320959-sgdqhtns 60 23 its -PRON- PRP$ cord-320959-sgdqhtns 60 24 activation activation NN cord-320959-sgdqhtns 60 25 of of IN cord-320959-sgdqhtns 60 26 the the DT cord-320959-sgdqhtns 60 27 xenobiotic xenobiotic NN cord-320959-sgdqhtns 60 28 - - HYPH cord-320959-sgdqhtns 60 29 sensing sense VBG cord-320959-sgdqhtns 60 30 pregnane pregnane NNP cord-320959-sgdqhtns 60 31 X X NNP cord-320959-sgdqhtns 60 32 receptor receptor NN cord-320959-sgdqhtns 60 33 ( ( -LRB- cord-320959-sgdqhtns 60 34 PXR pxr NN cord-320959-sgdqhtns 60 35 ) ) -RRB- cord-320959-sgdqhtns 60 36 signaling signaling NN cord-320959-sgdqhtns 60 37 , , , cord-320959-sgdqhtns 60 38 and and CC cord-320959-sgdqhtns 60 39 v v LS cord-320959-sgdqhtns 60 40 ) ) -RRB- cord-320959-sgdqhtns 60 41 its -PRON- PRP$ cord-320959-sgdqhtns 60 42 ability ability NN cord-320959-sgdqhtns 60 43 to to TO cord-320959-sgdqhtns 60 44 modulate modulate VB cord-320959-sgdqhtns 60 45 lateral lateral JJ cord-320959-sgdqhtns 60 46 phase phase NN cord-320959-sgdqhtns 60 47 separation separation NN cord-320959-sgdqhtns 60 48 . . . cord-320959-sgdqhtns 61 1 In in IN cord-320959-sgdqhtns 61 2 each each DT cord-320959-sgdqhtns 61 3 section section NN cord-320959-sgdqhtns 61 4 , , , cord-320959-sgdqhtns 61 5 10 10 CD cord-320959-sgdqhtns 61 6 I -PRON- PRP cord-320959-sgdqhtns 61 7 discuss discuss VBP cord-320959-sgdqhtns 61 8 possible possible JJ cord-320959-sgdqhtns 61 9 ways way NNS cord-320959-sgdqhtns 61 10 by by IN cord-320959-sgdqhtns 61 11 which which WDT cord-320959-sgdqhtns 61 12 these these DT cord-320959-sgdqhtns 61 13 properties property NNS cord-320959-sgdqhtns 61 14 may may MD cord-320959-sgdqhtns 61 15 contribute contribute VB cord-320959-sgdqhtns 61 16 to to IN cord-320959-sgdqhtns 61 17 the the DT cord-320959-sgdqhtns 61 18 pathophysiology pathophysiology NN cord-320959-sgdqhtns 61 19 of of IN cord-320959-sgdqhtns 61 20 EVALI EVALI NNS cord-320959-sgdqhtns 61 21 and and CC cord-320959-sgdqhtns 61 22 whether whether IN cord-320959-sgdqhtns 61 23 these these DT cord-320959-sgdqhtns 61 24 properties property NNS cord-320959-sgdqhtns 61 25 are be VBP cord-320959-sgdqhtns 61 26 expected expect VBN cord-320959-sgdqhtns 61 27 to to TO cord-320959-sgdqhtns 61 28 be be VB cord-320959-sgdqhtns 61 29 shared share VBN cord-320959-sgdqhtns 61 30 by by IN cord-320959-sgdqhtns 61 31 Vitamin vitamin NN cord-320959-sgdqhtns 61 32 E e NN cord-320959-sgdqhtns 61 33 acetate acetate NN cord-320959-sgdqhtns 61 34 . . . cord-320959-sgdqhtns 62 1 At at IN cord-320959-sgdqhtns 62 2 last last JJ cord-320959-sgdqhtns 62 3 , , , cord-320959-sgdqhtns 62 4 I -PRON- PRP cord-320959-sgdqhtns 62 5 argue argue VBP cord-320959-sgdqhtns 62 6 that that IN cord-320959-sgdqhtns 62 7 the the DT cord-320959-sgdqhtns 62 8 line line NN cord-320959-sgdqhtns 62 9 - - HYPH cord-320959-sgdqhtns 62 10 active active JJ cord-320959-sgdqhtns 62 11 property property NN cord-320959-sgdqhtns 62 12 of of IN cord-320959-sgdqhtns 62 13 the the DT cord-320959-sgdqhtns 62 14 vitamin vitamin NN cord-320959-sgdqhtns 62 15 deserves deserve VBZ cord-320959-sgdqhtns 62 16 academic academic JJ cord-320959-sgdqhtns 62 17 attention attention NN cord-320959-sgdqhtns 62 18 . . . cord-320959-sgdqhtns 63 1 Although although IN cord-320959-sgdqhtns 63 2 toxic toxic JJ cord-320959-sgdqhtns 63 3 byproducts byproduct NNS cord-320959-sgdqhtns 63 4 of of IN cord-320959-sgdqhtns 63 5 heating heat VBG cord-320959-sgdqhtns 63 6 Vitamin vitamin NN cord-320959-sgdqhtns 63 7 E e NN cord-320959-sgdqhtns 63 8 acetate acetate NN cord-320959-sgdqhtns 63 9 have have VBP cord-320959-sgdqhtns 63 10 recently recently RB cord-320959-sgdqhtns 63 11 garnered garner VBN cord-320959-sgdqhtns 63 12 considerable considerable JJ cord-320959-sgdqhtns 63 13 interest interest NN cord-320959-sgdqhtns 63 14 [ [ -LRB- cord-320959-sgdqhtns 63 15 31 31 CD cord-320959-sgdqhtns 63 16 ] ] -RRB- cord-320959-sgdqhtns 63 17 , , , cord-320959-sgdqhtns 63 18 I -PRON- PRP cord-320959-sgdqhtns 63 19 instead instead RB cord-320959-sgdqhtns 63 20 focus focus VBP cord-320959-sgdqhtns 63 21 on on IN cord-320959-sgdqhtns 63 22 the the DT cord-320959-sgdqhtns 63 23 biological biological JJ cord-320959-sgdqhtns 63 24 action action NN cord-320959-sgdqhtns 63 25 of of IN cord-320959-sgdqhtns 63 26 the the DT cord-320959-sgdqhtns 63 27 vitamin vitamin NN cord-320959-sgdqhtns 63 28 derivative derivative NN cord-320959-sgdqhtns 63 29 itself -PRON- PRP cord-320959-sgdqhtns 63 30 , , , cord-320959-sgdqhtns 63 31 as as IN cord-320959-sgdqhtns 63 32 there there EX cord-320959-sgdqhtns 63 33 is be VBZ cord-320959-sgdqhtns 63 34 yet yet RB cord-320959-sgdqhtns 63 35 lacking lack VBG cord-320959-sgdqhtns 63 36 15 15 CD cord-320959-sgdqhtns 63 37 amount amount NN cord-320959-sgdqhtns 63 38 of of IN cord-320959-sgdqhtns 63 39 evidence evidence NN cord-320959-sgdqhtns 63 40 that that WDT cord-320959-sgdqhtns 63 41 pinpoints pinpoint VBZ cord-320959-sgdqhtns 63 42 toxic toxic JJ cord-320959-sgdqhtns 63 43 byproducts byproduct NNS cord-320959-sgdqhtns 63 44 as as IN cord-320959-sgdqhtns 63 45 the the DT cord-320959-sgdqhtns 63 46 pathological pathological JJ cord-320959-sgdqhtns 63 47 driving driving NN cord-320959-sgdqhtns 63 48 force force NN cord-320959-sgdqhtns 63 49 for for IN cord-320959-sgdqhtns 63 50 EVALI EVALI NNS cord-320959-sgdqhtns 63 51 . . . cord-320959-sgdqhtns 64 1 Indeed indeed RB cord-320959-sgdqhtns 64 2 , , , cord-320959-sgdqhtns 64 3 Lanzarotta Lanzarotta NNP cord-320959-sgdqhtns 64 4 and and CC cord-320959-sgdqhtns 64 5 colleagues colleague NNS cord-320959-sgdqhtns 64 6 have have VBP cord-320959-sgdqhtns 64 7 recently recently RB cord-320959-sgdqhtns 64 8 shown show VBN cord-320959-sgdqhtns 64 9 that that IN cord-320959-sgdqhtns 64 10 the the DT cord-320959-sgdqhtns 64 11 majority majority NN cord-320959-sgdqhtns 64 12 of of IN cord-320959-sgdqhtns 64 13 vaporized vaporize VBN cord-320959-sgdqhtns 64 14 Vitamin vitamin NN cord-320959-sgdqhtns 64 15 E e NN cord-320959-sgdqhtns 64 16 acetate acetate NN cord-320959-sgdqhtns 64 17 exist exist VBP cord-320959-sgdqhtns 64 18 either either CC cord-320959-sgdqhtns 64 19 as as IN cord-320959-sgdqhtns 64 20 an an DT cord-320959-sgdqhtns 64 21 equimolar equimolar JJ cord-320959-sgdqhtns 64 22 complex complex NN cord-320959-sgdqhtns 64 23 with with IN cord-320959-sgdqhtns 64 24 THC thc NN cord-320959-sgdqhtns 64 25 or or CC cord-320959-sgdqhtns 64 26 as as IN cord-320959-sgdqhtns 64 27 a a DT cord-320959-sgdqhtns 64 28 dimer dimer NN cord-320959-sgdqhtns 64 29 [ [ -LRB- cord-320959-sgdqhtns 64 30 32 32 CD cord-320959-sgdqhtns 64 31 ] ] -RRB- cord-320959-sgdqhtns 64 32 . . . cord-320959-sgdqhtns 65 1 20 20 CD cord-320959-sgdqhtns 66 1 Among among IN cord-320959-sgdqhtns 66 2 the the DT cord-320959-sgdqhtns 66 3 five five CD cord-320959-sgdqhtns 66 4 non non JJ cord-320959-sgdqhtns 66 5 - - JJ cord-320959-sgdqhtns 66 6 antioxidative antioxidative JJ cord-320959-sgdqhtns 66 7 properties property NNS cord-320959-sgdqhtns 66 8 of of IN cord-320959-sgdqhtns 66 9 Vitamin vitamin NN cord-320959-sgdqhtns 66 10 E e NN cord-320959-sgdqhtns 66 11 , , , cord-320959-sgdqhtns 66 12 investigators investigator NNS cord-320959-sgdqhtns 66 13 from from IN cord-320959-sgdqhtns 66 14 the the DT cord-320959-sgdqhtns 66 15 Lung Lung NNP cord-320959-sgdqhtns 66 16 Injury Injury NNP cord-320959-sgdqhtns 66 17 Response Response NNP cord-320959-sgdqhtns 66 18 Laboratory Laboratory NNP cord-320959-sgdqhtns 66 19 Working Working NNP cord-320959-sgdqhtns 66 20 Group Group NNP cord-320959-sgdqhtns 66 21 have have VBP cord-320959-sgdqhtns 66 22 focused focus VBN cord-320959-sgdqhtns 66 23 on on IN cord-320959-sgdqhtns 66 24 its -PRON- PRP$ cord-320959-sgdqhtns 66 25 peculiar peculiar JJ cord-320959-sgdqhtns 66 26 ability ability NN cord-320959-sgdqhtns 66 27 to to TO cord-320959-sgdqhtns 66 28 induce induce VB cord-320959-sgdqhtns 66 29 gel gel NN cord-320959-sgdqhtns 66 30 ( ( -LRB- cord-320959-sgdqhtns 66 31 L L NNP cord-320959-sgdqhtns 66 32 β β NN cord-320959-sgdqhtns 66 33 ) ) -RRB- cord-320959-sgdqhtns 66 34 to to TO cord-320959-sgdqhtns 66 35 liquid liquid JJ cord-320959-sgdqhtns 66 36 crystalline crystalline NN cord-320959-sgdqhtns 67 1 ( ( -LRB- cord-320959-sgdqhtns 67 2 L L NNP cord-320959-sgdqhtns 67 3 c c NN cord-320959-sgdqhtns 67 4 ) ) -RRB- cord-320959-sgdqhtns 67 5 phase phase NN cord-320959-sgdqhtns 67 6 transition transition NN cord-320959-sgdqhtns 67 7 in in IN cord-320959-sgdqhtns 67 8 model model NN cord-320959-sgdqhtns 67 9 saturated saturate VBN cord-320959-sgdqhtns 67 10 phosphatidylcholine phosphatidylcholine NN cord-320959-sgdqhtns 67 11 bilayers bilayer NNS cord-320959-sgdqhtns 67 12 [ [ -LRB- cord-320959-sgdqhtns 67 13 12 12 CD cord-320959-sgdqhtns 67 14 ] ] -RRB- cord-320959-sgdqhtns 68 1 ( ( -LRB- cord-320959-sgdqhtns 68 2 L l NN cord-320959-sgdqhtns 68 3 in in IN cord-320959-sgdqhtns 68 4 the the DT cord-320959-sgdqhtns 68 5 notation notation NN cord-320959-sgdqhtns 68 6 stands stand VBZ cord-320959-sgdqhtns 68 7 for for IN cord-320959-sgdqhtns 68 8 lamellar lamellar NN cord-320959-sgdqhtns 68 9 ) ) -RRB- cord-320959-sgdqhtns 68 10 . . . cord-320959-sgdqhtns 69 1 This this DT cord-320959-sgdqhtns 69 2 property property NN cord-320959-sgdqhtns 69 3 of of IN cord-320959-sgdqhtns 69 4 the the DT cord-320959-sgdqhtns 69 5 vitamin vitamin NN cord-320959-sgdqhtns 69 6 is be VBZ cord-320959-sgdqhtns 69 7 believed believe VBN cord-320959-sgdqhtns 69 8 to to TO cord-320959-sgdqhtns 69 9 be be VB cord-320959-sgdqhtns 69 10 the the DT cord-320959-sgdqhtns 69 11 consequence consequence NN cord-320959-sgdqhtns 69 12 8 8 CD cord-320959-sgdqhtns 69 13 of of IN cord-320959-sgdqhtns 69 14 its -PRON- PRP$ cord-320959-sgdqhtns 69 15 structural structural JJ cord-320959-sgdqhtns 69 16 deviance deviance NN cord-320959-sgdqhtns 69 17 from from IN cord-320959-sgdqhtns 69 18 phospholipids phospholipid NNS cord-320959-sgdqhtns 69 19 . . . cord-320959-sgdqhtns 70 1 As as IN cord-320959-sgdqhtns 70 2 the the DT cord-320959-sgdqhtns 70 3 structure structure NN cord-320959-sgdqhtns 70 4 of of IN cord-320959-sgdqhtns 70 5 Vitamin vitamin NN cord-320959-sgdqhtns 70 6 E e NN cord-320959-sgdqhtns 70 7 greatly greatly RB cord-320959-sgdqhtns 70 8 differs differ VBZ cord-320959-sgdqhtns 70 9 from from IN cord-320959-sgdqhtns 70 10 a a DT cord-320959-sgdqhtns 70 11 typical typical JJ cord-320959-sgdqhtns 70 12 phospholipid phospholipid NN cord-320959-sgdqhtns 70 13 , , , cord-320959-sgdqhtns 70 14 especially especially RB cord-320959-sgdqhtns 70 15 in in IN cord-320959-sgdqhtns 70 16 its -PRON- PRP$ cord-320959-sgdqhtns 70 17 rigid rigid JJ cord-320959-sgdqhtns 70 18 chromane chromane NN cord-320959-sgdqhtns 70 19 double double JJ cord-320959-sgdqhtns 70 20 ring ring NN cord-320959-sgdqhtns 70 21 , , , cord-320959-sgdqhtns 70 22 the the DT cord-320959-sgdqhtns 70 23 vitamin vitamin NN cord-320959-sgdqhtns 70 24 greatly greatly RB cord-320959-sgdqhtns 70 25 perturbs perturb VBZ cord-320959-sgdqhtns 70 26 the the DT cord-320959-sgdqhtns 70 27 packing packing NN cord-320959-sgdqhtns 70 28 of of IN cord-320959-sgdqhtns 70 29 phospholipids phospholipid NNS cord-320959-sgdqhtns 70 30 within within IN cord-320959-sgdqhtns 70 31 the the DT cord-320959-sgdqhtns 70 32 L L NNP cord-320959-sgdqhtns 70 33 β β NN cord-320959-sgdqhtns 70 34 phase phase NN cord-320959-sgdqhtns 70 35 , , , cord-320959-sgdqhtns 70 36 resulting result VBG cord-320959-sgdqhtns 70 37 in in IN cord-320959-sgdqhtns 70 38 a a DT cord-320959-sgdqhtns 70 39 facilitated facilitate VBN cord-320959-sgdqhtns 70 40 gel gel NN cord-320959-sgdqhtns 70 41 - - HYPH cord-320959-sgdqhtns 70 42 liquid liquid NN cord-320959-sgdqhtns 70 43 crystalline crystalline NN cord-320959-sgdqhtns 70 44 phase phase NN cord-320959-sgdqhtns 70 45 transition transition NN cord-320959-sgdqhtns 70 46 ( ( -LRB- cord-320959-sgdqhtns 70 47 Fig Fig NNP cord-320959-sgdqhtns 70 48 . . . cord-320959-sgdqhtns 70 49 1 1 CD cord-320959-sgdqhtns 70 50 ) ) -RRB- cord-320959-sgdqhtns 71 1 [ [ -LRB- cord-320959-sgdqhtns 71 2 33 33 CD cord-320959-sgdqhtns 71 3 ] ] -RRB- cord-320959-sgdqhtns 71 4 . . . cord-320959-sgdqhtns 72 1 For for IN cord-320959-sgdqhtns 72 2 instance instance NN cord-320959-sgdqhtns 72 3 , , , cord-320959-sgdqhtns 72 4 the the DT cord-320959-sgdqhtns 72 5 addition addition NN cord-320959-sgdqhtns 72 6 of of IN cord-320959-sgdqhtns 72 7 either either CC cord-320959-sgdqhtns 72 8 Vitamin vitamin NN cord-320959-sgdqhtns 72 9 E e NN cord-320959-sgdqhtns 72 10 or or CC cord-320959-sgdqhtns 72 11 Vitamin vitamin NN cord-320959-sgdqhtns 72 12 E e NN cord-320959-sgdqhtns 72 13 acetate acetate NN cord-320959-sgdqhtns 72 14 5 5 CD cord-320959-sgdqhtns 72 15 in in IN cord-320959-sgdqhtns 72 16 molar molar JJ cord-320959-sgdqhtns 72 17 ratios ratio NNS cord-320959-sgdqhtns 72 18 as as RB cord-320959-sgdqhtns 72 19 high high JJ cord-320959-sgdqhtns 72 20 as as IN cord-320959-sgdqhtns 72 21 16 16 CD cord-320959-sgdqhtns 72 22 mol% mol% CD cord-320959-sgdqhtns 72 23 in in IN cord-320959-sgdqhtns 72 24 cholesterol cholesterol NN cord-320959-sgdqhtns 72 25 - - HYPH cord-320959-sgdqhtns 72 26 free free JJ cord-320959-sgdqhtns 72 27 model model NN cord-320959-sgdqhtns 72 28 dimyristoylphosphatidylcholine dimyristoylphosphatidylcholine NN cord-320959-sgdqhtns 72 29 ( ( -LRB- cord-320959-sgdqhtns 72 30 DMPC DMPC NNP cord-320959-sgdqhtns 72 31 ) ) -RRB- cord-320959-sgdqhtns 72 32 membranes membrane NNS cord-320959-sgdqhtns 72 33 lowers lower VBZ cord-320959-sgdqhtns 72 34 the the DT cord-320959-sgdqhtns 72 35 critical critical JJ cord-320959-sgdqhtns 72 36 temperature temperature NN cord-320959-sgdqhtns 72 37 required require VBN cord-320959-sgdqhtns 72 38 for for IN cord-320959-sgdqhtns 72 39 gel gel NN cord-320959-sgdqhtns 72 40 - - HYPH cord-320959-sgdqhtns 72 41 liquid liquid NN cord-320959-sgdqhtns 72 42 crystalline crystalline NN cord-320959-sgdqhtns 72 43 phase phase NN cord-320959-sgdqhtns 72 44 transition transition NN cord-320959-sgdqhtns 72 45 for for IN cord-320959-sgdqhtns 72 46 ~1.2 ~1.2 CD cord-320959-sgdqhtns 72 47 K k XX cord-320959-sgdqhtns 72 48 [ [ -LRB- cord-320959-sgdqhtns 72 49 33 33 CD cord-320959-sgdqhtns 72 50 , , , cord-320959-sgdqhtns 72 51 34 34 CD cord-320959-sgdqhtns 72 52 ] ] -RRB- cord-320959-sgdqhtns 72 53 . . . cord-320959-sgdqhtns 73 1 However however RB cord-320959-sgdqhtns 73 2 , , , cord-320959-sgdqhtns 73 3 since since IN cord-320959-sgdqhtns 73 4 cholesterol cholesterol NN cord-320959-sgdqhtns 73 5 , , , cord-320959-sgdqhtns 73 6 a a DT cord-320959-sgdqhtns 73 7 major major JJ cord-320959-sgdqhtns 73 8 constituent constituent NN cord-320959-sgdqhtns 73 9 of of IN cord-320959-sgdqhtns 73 10 biological biological JJ cord-320959-sgdqhtns 73 11 membranes membrane NNS cord-320959-sgdqhtns 73 12 , , , cord-320959-sgdqhtns 73 13 also also RB cord-320959-sgdqhtns 73 14 exhibits exhibit VBZ cord-320959-sgdqhtns 73 15 profound profound JJ cord-320959-sgdqhtns 73 16 structural structural JJ cord-320959-sgdqhtns 73 17 deviance deviance NN cord-320959-sgdqhtns 73 18 from from IN cord-320959-sgdqhtns 73 19 a a DT cord-320959-sgdqhtns 73 20 typical typical JJ cord-320959-sgdqhtns 73 21 phospholipid phospholipid NN cord-320959-sgdqhtns 73 22 , , , cord-320959-sgdqhtns 73 23 it -PRON- PRP cord-320959-sgdqhtns 73 24 also also RB cord-320959-sgdqhtns 73 25 facilitates facilitate VBZ cord-320959-sgdqhtns 73 26 gel gel NN cord-320959-sgdqhtns 73 27 - - HYPH cord-320959-sgdqhtns 73 28 liquid liquid NN cord-320959-sgdqhtns 73 29 crystalline crystalline NN cord-320959-sgdqhtns 73 30 phase phase NN cord-320959-sgdqhtns 73 31 transition transition NN cord-320959-sgdqhtns 73 32 in in IN cord-320959-sgdqhtns 73 33 a a DT cord-320959-sgdqhtns 73 34 similar similar JJ cord-320959-sgdqhtns 73 35 manner manner NN cord-320959-sgdqhtns 73 36 . . . cord-320959-sgdqhtns 74 1 Compared compare VBN cord-320959-sgdqhtns 74 2 to to TO cord-320959-sgdqhtns 74 3 free free VB cord-320959-sgdqhtns 74 4 10 10 CD cord-320959-sgdqhtns 74 5 cholesterol cholesterol NN cord-320959-sgdqhtns 74 6 , , , cord-320959-sgdqhtns 74 7 Vitamin vitamin NN cord-320959-sgdqhtns 74 8 E e NN cord-320959-sgdqhtns 74 9 acetate acetate NN cord-320959-sgdqhtns 74 10 is be VBZ cord-320959-sgdqhtns 74 11 1.5 1.5 CD cord-320959-sgdqhtns 74 12 times time NNS cord-320959-sgdqhtns 74 13 more more RBR cord-320959-sgdqhtns 74 14 potent potent JJ cord-320959-sgdqhtns 74 15 in in IN cord-320959-sgdqhtns 74 16 modulating modulate VBG cord-320959-sgdqhtns 74 17 the the DT cord-320959-sgdqhtns 74 18 phase phase NN cord-320959-sgdqhtns 74 19 behavior behavior NN cord-320959-sgdqhtns 74 20 of of IN cord-320959-sgdqhtns 74 21 the the DT cord-320959-sgdqhtns 74 22 lipid lipid NN cord-320959-sgdqhtns 74 23 bilayer bilayer NN cord-320959-sgdqhtns 74 24 . . . cord-320959-sgdqhtns 75 1 As as IN cord-320959-sgdqhtns 75 2 a a DT cord-320959-sgdqhtns 75 3 consequence consequence NN cord-320959-sgdqhtns 75 4 , , , cord-320959-sgdqhtns 75 5 one one CD cord-320959-sgdqhtns 75 6 possible possible JJ cord-320959-sgdqhtns 75 7 mechanism mechanism NN cord-320959-sgdqhtns 75 8 by by IN cord-320959-sgdqhtns 75 9 which which WDT cord-320959-sgdqhtns 75 10 Vitamin vitamin NN cord-320959-sgdqhtns 75 11 E e NN cord-320959-sgdqhtns 75 12 acetate acetate NN cord-320959-sgdqhtns 75 13 intoxication intoxication NN cord-320959-sgdqhtns 75 14 may may MD cord-320959-sgdqhtns 75 15 lead lead VB cord-320959-sgdqhtns 75 16 to to IN cord-320959-sgdqhtns 75 17 a a DT cord-320959-sgdqhtns 75 18 fatal fatal JJ cord-320959-sgdqhtns 75 19 lung lung NN cord-320959-sgdqhtns 75 20 injury injury NN cord-320959-sgdqhtns 75 21 is be VBZ cord-320959-sgdqhtns 75 22 its -PRON- PRP$ cord-320959-sgdqhtns 75 23 induction induction NN cord-320959-sgdqhtns 75 24 of of IN cord-320959-sgdqhtns 75 25 liquid liquid JJ cord-320959-sgdqhtns 75 26 crystalline crystalline NN cord-320959-sgdqhtns 75 27 phase phase NN cord-320959-sgdqhtns 75 28 in in IN cord-320959-sgdqhtns 75 29 pulmonary pulmonary JJ cord-320959-sgdqhtns 75 30 surfactants surfactant NNS cord-320959-sgdqhtns 75 31 , , , cord-320959-sgdqhtns 75 32 which which WDT cord-320959-sgdqhtns 75 33 would would MD cord-320959-sgdqhtns 75 34 likely likely RB cord-320959-sgdqhtns 75 35 influence influence VB cord-320959-sgdqhtns 75 36 the the DT cord-320959-sgdqhtns 75 37 respiratory respiratory JJ cord-320959-sgdqhtns 75 38 compression compression NN cord-320959-sgdqhtns 75 39 - - HYPH cord-320959-sgdqhtns 75 40 expansion expansion NN cord-320959-sgdqhtns 75 41 cycling cycling NN cord-320959-sgdqhtns 75 42 . . . cord-320959-sgdqhtns 76 1 15 15 CD cord-320959-sgdqhtns 77 1 A a DT cord-320959-sgdqhtns 77 2 major major JJ cord-320959-sgdqhtns 77 3 downfall downfall NN cord-320959-sgdqhtns 77 4 of of IN cord-320959-sgdqhtns 77 5 Blount Blount NNP cord-320959-sgdqhtns 77 6 and and CC cord-320959-sgdqhtns 77 7 his -PRON- PRP$ cord-320959-sgdqhtns 77 8 colleagues colleague NNS cord-320959-sgdqhtns 77 9 ' ' POS cord-320959-sgdqhtns 77 10 hypothesis hypothesis NN cord-320959-sgdqhtns 77 11 is be VBZ cord-320959-sgdqhtns 77 12 the the DT cord-320959-sgdqhtns 77 13 abundance abundance NN cord-320959-sgdqhtns 77 14 of of IN cord-320959-sgdqhtns 77 15 free free JJ cord-320959-sgdqhtns 77 16 cholesterol cholesterol NN cord-320959-sgdqhtns 77 17 in in IN cord-320959-sgdqhtns 77 18 human human JJ cord-320959-sgdqhtns 77 19 pulmonary pulmonary JJ cord-320959-sgdqhtns 77 20 surfactants surfactant NNS cord-320959-sgdqhtns 77 21 . . . cord-320959-sgdqhtns 78 1 Indeed indeed RB cord-320959-sgdqhtns 78 2 , , , cord-320959-sgdqhtns 78 3 free free JJ cord-320959-sgdqhtns 78 4 cholesterol cholesterol NN cord-320959-sgdqhtns 78 5 level level NN cord-320959-sgdqhtns 78 6 in in IN cord-320959-sgdqhtns 78 7 BAL bal NN cord-320959-sgdqhtns 78 8 fluids fluid NNS cord-320959-sgdqhtns 78 9 were be VBD cord-320959-sgdqhtns 78 10 measured measure VBN cord-320959-sgdqhtns 78 11 as as IN cord-320959-sgdqhtns 78 12 ~2.6 ~2.6 CD cord-320959-sgdqhtns 78 13 mM mm CD cord-320959-sgdqhtns 78 14 in in IN cord-320959-sgdqhtns 78 15 murine murine JJ cord-320959-sgdqhtns 78 16 models model NNS cord-320959-sgdqhtns 78 17 of of IN cord-320959-sgdqhtns 78 18 pulmonary pulmonary JJ cord-320959-sgdqhtns 78 19 alveolar alveolar NN cord-320959-sgdqhtns 78 20 proteinosis proteinosis NN cord-320959-sgdqhtns 78 21 ( ( -LRB- cord-320959-sgdqhtns 78 22 PAP PAP NNP cord-320959-sgdqhtns 78 23 ) ) -RRB- cord-320959-sgdqhtns 78 24 [ [ -LRB- cord-320959-sgdqhtns 78 25 35 35 CD cord-320959-sgdqhtns 78 26 ] ] -RRB- cord-320959-sgdqhtns 78 27 , , . cord-320959-sgdqhtns 79 1 while while IN cord-320959-sgdqhtns 79 2 the the DT cord-320959-sgdqhtns 79 3 level level NN cord-320959-sgdqhtns 79 4 of of IN cord-320959-sgdqhtns 79 5 Vitamin vitamin NN cord-320959-sgdqhtns 79 6 E e NN cord-320959-sgdqhtns 79 7 acetate acetate NN cord-320959-sgdqhtns 79 8 observed observe VBD cord-320959-sgdqhtns 79 9 in in IN cord-320959-sgdqhtns 79 10 patients patient NNS cord-320959-sgdqhtns 79 11 with with IN cord-320959-sgdqhtns 79 12 EVALI EVALI NNS cord-320959-sgdqhtns 79 13 , , , cord-320959-sgdqhtns 79 14 who who WP cord-320959-sgdqhtns 79 15 occasionally occasionally RB cord-320959-sgdqhtns 79 16 feature feature VBP cord-320959-sgdqhtns 79 17 signs sign NNS cord-320959-sgdqhtns 79 18 of of IN cord-320959-sgdqhtns 79 19 PAP pap NN cord-320959-sgdqhtns 79 20 [ [ -LRB- cord-320959-sgdqhtns 79 21 36 36 CD cord-320959-sgdqhtns 79 22 ] ] -RRB- cord-320959-sgdqhtns 79 23 , , , cord-320959-sgdqhtns 79 24 was be VBD cord-320959-sgdqhtns 79 25 in in IN cord-320959-sgdqhtns 79 26 nanomolar nanomolar JJ cord-320959-sgdqhtns 79 27 range range NN cord-320959-sgdqhtns 79 28 [ [ -LRB- cord-320959-sgdqhtns 79 29 12 12 CD cord-320959-sgdqhtns 79 30 ] ] -RRB- cord-320959-sgdqhtns 79 31 . . . cord-320959-sgdqhtns 80 1 In in IN cord-320959-sgdqhtns 80 2 contrast contrast NN cord-320959-sgdqhtns 80 3 , , , cord-320959-sgdqhtns 80 4 the the DT cord-320959-sgdqhtns 80 5 decrease decrease NN cord-320959-sgdqhtns 80 6 in in IN cord-320959-sgdqhtns 80 7 the the DT cord-320959-sgdqhtns 80 8 critical critical JJ cord-320959-sgdqhtns 80 9 temperature temperature NN cord-320959-sgdqhtns 80 10 induced induce VBN cord-320959-sgdqhtns 80 11 by by IN cord-320959-sgdqhtns 80 12 the the DT cord-320959-sgdqhtns 80 13 20 20 CD cord-320959-sgdqhtns 80 14 addition addition NN cord-320959-sgdqhtns 80 15 of of IN cord-320959-sgdqhtns 80 16 Vitamin vitamin NN cord-320959-sgdqhtns 80 17 E e NN cord-320959-sgdqhtns 80 18 acetate acetate NN cord-320959-sgdqhtns 80 19 was be VBD cord-320959-sgdqhtns 80 20 of of IN cord-320959-sgdqhtns 80 21 roughly roughly RB cord-320959-sgdqhtns 80 22 the the DT cord-320959-sgdqhtns 80 23 same same JJ cord-320959-sgdqhtns 80 24 orders order NNS cord-320959-sgdqhtns 80 25 of of IN cord-320959-sgdqhtns 80 26 magnitude magnitude NN cord-320959-sgdqhtns 80 27 compared compare VBN cord-320959-sgdqhtns 80 28 to to IN cord-320959-sgdqhtns 80 29 that that DT cord-320959-sgdqhtns 80 30 of of IN cord-320959-sgdqhtns 80 31 free free JJ cord-320959-sgdqhtns 80 32 cholesterol cholesterol NN cord-320959-sgdqhtns 80 33 . . . cord-320959-sgdqhtns 81 1 This this DT cord-320959-sgdqhtns 81 2 indicates indicate VBZ cord-320959-sgdqhtns 81 3 that that IN cord-320959-sgdqhtns 81 4 the the DT cord-320959-sgdqhtns 81 5 overall overall JJ cord-320959-sgdqhtns 81 6 contribution contribution NN cord-320959-sgdqhtns 81 7 of of IN cord-320959-sgdqhtns 81 8 Vitamin vitamin NN cord-320959-sgdqhtns 81 9 E e NN cord-320959-sgdqhtns 81 10 acetate acetate NN cord-320959-sgdqhtns 81 11 in in IN cord-320959-sgdqhtns 81 12 the the DT cord-320959-sgdqhtns 81 13 modulation modulation NN cord-320959-sgdqhtns 81 14 of of IN cord-320959-sgdqhtns 81 15 phase phase NN cord-320959-sgdqhtns 81 16 behavior behavior NN cord-320959-sgdqhtns 81 17 is be VBZ cord-320959-sgdqhtns 81 18 at at RB cord-320959-sgdqhtns 81 19 least least RBS cord-320959-sgdqhtns 81 20 three three CD cord-320959-sgdqhtns 81 21 orders order NNS cord-320959-sgdqhtns 81 22 of of IN cord-320959-sgdqhtns 81 23 magnitude magnitude NN cord-320959-sgdqhtns 81 24 smaller small JJR cord-320959-sgdqhtns 81 25 compared compare VBN cord-320959-sgdqhtns 81 26 to to IN cord-320959-sgdqhtns 81 27 that that DT cord-320959-sgdqhtns 81 28 of of IN cord-320959-sgdqhtns 81 29 endogenously endogenously RB cord-320959-sgdqhtns 81 30 available available JJ cord-320959-sgdqhtns 81 31 free free JJ cord-320959-sgdqhtns 81 32 cholesterol cholesterol NN cord-320959-sgdqhtns 81 33 . . . cord-320959-sgdqhtns 82 1 Furthermore furthermore RB cord-320959-sgdqhtns 82 2 , , , cord-320959-sgdqhtns 82 3 the the DT cord-320959-sgdqhtns 82 4 existence existence NN cord-320959-sgdqhtns 82 5 of of IN cord-320959-sgdqhtns 82 6 cholesterol cholesterol NN cord-320959-sgdqhtns 82 7 in in IN cord-320959-sgdqhtns 82 8 human human JJ cord-320959-sgdqhtns 82 9 pulmonary pulmonary JJ cord-320959-sgdqhtns 82 10 surfactants surfactant NNS cord-320959-sgdqhtns 82 11 is be VBZ cord-320959-sgdqhtns 82 12 known know VBN cord-320959-sgdqhtns 82 13 to to TO cord-320959-sgdqhtns 82 14 completely completely RB cord-320959-sgdqhtns 82 15 abrogate abrogate VB cord-320959-sgdqhtns 82 16 gel gel NN cord-320959-sgdqhtns 82 17 - - HYPH cord-320959-sgdqhtns 82 18 liquid liquid NN cord-320959-sgdqhtns 82 19 crystalline crystalline NN cord-320959-sgdqhtns 82 20 phase phase NN cord-320959-sgdqhtns 82 21 transition transition NN cord-320959-sgdqhtns 82 22 [ [ -LRB- cord-320959-sgdqhtns 82 23 37 37 CD cord-320959-sgdqhtns 82 24 ] ] -RRB- cord-320959-sgdqhtns 82 25 . . . cord-320959-sgdqhtns 83 1 In in IN cord-320959-sgdqhtns 83 2 explanation explanation NN cord-320959-sgdqhtns 83 3 , , , cord-320959-sgdqhtns 83 4 the the DT cord-320959-sgdqhtns 83 5 driving drive VBG cord-320959-sgdqhtns 83 6 force force NN cord-320959-sgdqhtns 83 7 for for IN cord-320959-sgdqhtns 83 8 gel gel NN cord-320959-sgdqhtns 83 9 - - HYPH cord-320959-sgdqhtns 83 10 liquid liquid NN cord-320959-sgdqhtns 83 11 crystalline crystalline NN cord-320959-sgdqhtns 83 12 phase phase NN cord-320959-sgdqhtns 83 13 transition transition NN cord-320959-sgdqhtns 83 14 induced induce VBN cord-320959-sgdqhtns 83 15 by by IN cord-320959-sgdqhtns 83 16 Vitamin vitamin NN cord-320959-sgdqhtns 83 17 E e NN cord-320959-sgdqhtns 83 18 acetate acetate NN cord-320959-sgdqhtns 83 19 in in IN cord-320959-sgdqhtns 83 20 model model NN cord-320959-sgdqhtns 83 21 saturated saturate VBN cord-320959-sgdqhtns 83 22 phosphatidylcholine phosphatidylcholine NN cord-320959-sgdqhtns 83 23 bilayers bilayer NNS cord-320959-sgdqhtns 83 24 has have VBZ cord-320959-sgdqhtns 83 25 been be VBN cord-320959-sgdqhtns 83 26 its -PRON- PRP$ cord-320959-sgdqhtns 83 27 perturbation perturbation NN cord-320959-sgdqhtns 83 28 of of IN cord-320959-sgdqhtns 83 29 phospholipid phospholipid NN cord-320959-sgdqhtns 83 30 packing packing NN cord-320959-sgdqhtns 83 31 by by IN cord-320959-sgdqhtns 83 32 structural structural JJ cord-320959-sgdqhtns 83 33 deviance deviance NN cord-320959-sgdqhtns 83 34 . . . cord-320959-sgdqhtns 84 1 The the DT cord-320959-sgdqhtns 84 2 abundance abundance NN cord-320959-sgdqhtns 84 3 of of IN cord-320959-sgdqhtns 84 4 free free JJ cord-320959-sgdqhtns 84 5 cholesterol cholesterol NN cord-320959-sgdqhtns 84 6 , , , cord-320959-sgdqhtns 84 7 of of IN cord-320959-sgdqhtns 84 8 which which WDT cord-320959-sgdqhtns 84 9 5 5 CD cord-320959-sgdqhtns 84 10 structure structure NN cord-320959-sgdqhtns 84 11 is be VBZ cord-320959-sgdqhtns 84 12 as as RB cord-320959-sgdqhtns 84 13 rigid rigid JJ cord-320959-sgdqhtns 84 14 as as IN cord-320959-sgdqhtns 84 15 the the DT cord-320959-sgdqhtns 84 16 head head NN cord-320959-sgdqhtns 84 17 portion portion NN cord-320959-sgdqhtns 84 18 of of IN cord-320959-sgdqhtns 84 19 the the DT cord-320959-sgdqhtns 84 20 vitamin vitamin NN cord-320959-sgdqhtns 84 21 , , , cord-320959-sgdqhtns 84 22 in in IN cord-320959-sgdqhtns 84 23 biological biological JJ cord-320959-sgdqhtns 84 24 membranes membrane NNS cord-320959-sgdqhtns 84 25 offsets offsets VBP cord-320959-sgdqhtns 84 26 the the DT cord-320959-sgdqhtns 84 27 structural structural JJ cord-320959-sgdqhtns 84 28 deviance deviance NN cord-320959-sgdqhtns 84 29 of of IN cord-320959-sgdqhtns 84 30 Vitamin vitamin NN cord-320959-sgdqhtns 84 31 E e NN cord-320959-sgdqhtns 84 32 in in IN cord-320959-sgdqhtns 84 33 lipid lipid NN cord-320959-sgdqhtns 84 34 bilayers bilayer NNS cord-320959-sgdqhtns 84 35 , , , cord-320959-sgdqhtns 84 36 resulting result VBG cord-320959-sgdqhtns 84 37 in in IN cord-320959-sgdqhtns 84 38 an an DT cord-320959-sgdqhtns 84 39 inability inability NN cord-320959-sgdqhtns 84 40 to to TO cord-320959-sgdqhtns 84 41 induce induce VB cord-320959-sgdqhtns 84 42 gel gel NN cord-320959-sgdqhtns 84 43 - - HYPH cord-320959-sgdqhtns 84 44 liquid liquid NN cord-320959-sgdqhtns 84 45 crystalline crystalline NN cord-320959-sgdqhtns 84 46 phase phase NN cord-320959-sgdqhtns 84 47 transition transition NN cord-320959-sgdqhtns 85 1 ( ( -LRB- cord-320959-sgdqhtns 85 2 Fig Fig NNP cord-320959-sgdqhtns 85 3 . . NNP cord-320959-sgdqhtns 85 4 1 1 CD cord-320959-sgdqhtns 85 5 ) ) -RRB- cord-320959-sgdqhtns 85 6 . . . cord-320959-sgdqhtns 86 1 Indeed indeed RB cord-320959-sgdqhtns 86 2 , , , cord-320959-sgdqhtns 86 3 the the DT cord-320959-sgdqhtns 86 4 observation observation NN cord-320959-sgdqhtns 86 5 of of IN cord-320959-sgdqhtns 86 6 gel gel NN cord-320959-sgdqhtns 86 7 - - HYPH cord-320959-sgdqhtns 86 8 liquid liquid NN cord-320959-sgdqhtns 86 9 crystalline crystalline NN cord-320959-sgdqhtns 86 10 phase phase NN cord-320959-sgdqhtns 86 11 transition transition NN cord-320959-sgdqhtns 86 12 has have VBZ cord-320959-sgdqhtns 86 13 been be VBN cord-320959-sgdqhtns 86 14 limited limit VBN cord-320959-sgdqhtns 86 15 to to IN cord-320959-sgdqhtns 86 16 the the DT cord-320959-sgdqhtns 86 17 cholesterol cholesterol NN cord-320959-sgdqhtns 86 18 - - HYPH cord-320959-sgdqhtns 86 19 free free JJ cord-320959-sgdqhtns 86 20 model model NN cord-320959-sgdqhtns 86 21 saturated saturate VBN cord-320959-sgdqhtns 86 22 phosphatidylcholine phosphatidylcholine NN cord-320959-sgdqhtns 86 23 bilayers bilayer NNS cord-320959-sgdqhtns 86 24 [ [ -LRB- cord-320959-sgdqhtns 86 25 33 33 CD cord-320959-sgdqhtns 86 26 , , , cord-320959-sgdqhtns 86 27 34 34 CD cord-320959-sgdqhtns 86 28 ] ] -RRB- cord-320959-sgdqhtns 86 29 and and CC cord-320959-sgdqhtns 86 30 the the DT cord-320959-sgdqhtns 86 31 membrane membrane NN cord-320959-sgdqhtns 86 32 of of IN cord-320959-sgdqhtns 86 33 Mycoplasma Mycoplasma NNP cord-320959-sgdqhtns 86 34 laidlawii laidlawii NNP cord-320959-sgdqhtns 86 35 , , , cord-320959-sgdqhtns 86 36 which which WDT cord-320959-sgdqhtns 86 37 is be VBZ cord-320959-sgdqhtns 86 38 depleted deplete VBN cord-320959-sgdqhtns 86 39 of of IN cord-320959-sgdqhtns 86 40 cholesterol cholesterol NN cord-320959-sgdqhtns 86 41 and and CC cord-320959-sgdqhtns 86 42 is be VBZ cord-320959-sgdqhtns 86 43 10 10 CD cord-320959-sgdqhtns 86 44 enriched enrich VBN cord-320959-sgdqhtns 86 45 with with IN cord-320959-sgdqhtns 86 46 saturated saturated JJ cord-320959-sgdqhtns 86 47 fatty fatty JJ cord-320959-sgdqhtns 86 48 acids acid NNS cord-320959-sgdqhtns 86 49 [ [ -LRB- cord-320959-sgdqhtns 86 50 38 38 CD cord-320959-sgdqhtns 86 51 ] ] -RRB- cord-320959-sgdqhtns 86 52 . . . cord-320959-sgdqhtns 87 1 Accounting account VBG cord-320959-sgdqhtns 87 2 for for IN cord-320959-sgdqhtns 87 3 the the DT cord-320959-sgdqhtns 87 4 rationale rationale NN cord-320959-sgdqhtns 87 5 behind behind IN cord-320959-sgdqhtns 87 6 the the DT cord-320959-sgdqhtns 87 7 selection selection NN cord-320959-sgdqhtns 87 8 of of IN cord-320959-sgdqhtns 87 9 Mycoplasma Mycoplasma NNP cord-320959-sgdqhtns 87 10 laidlawii laidlawii NNP cord-320959-sgdqhtns 87 11 as as IN cord-320959-sgdqhtns 87 12 the the DT cord-320959-sgdqhtns 87 13 model model NN cord-320959-sgdqhtns 87 14 system system NN cord-320959-sgdqhtns 87 15 for for IN cord-320959-sgdqhtns 87 16 investigating investigate VBG cord-320959-sgdqhtns 87 17 gel gel NN cord-320959-sgdqhtns 87 18 - - HYPH cord-320959-sgdqhtns 87 19 liquid liquid NN cord-320959-sgdqhtns 87 20 crystalline crystalline NN cord-320959-sgdqhtns 87 21 phase phase NN cord-320959-sgdqhtns 87 22 transition transition NN cord-320959-sgdqhtns 87 23 , , , cord-320959-sgdqhtns 87 24 Steim Steim NNP cord-320959-sgdqhtns 87 25 and and CC cord-320959-sgdqhtns 87 26 colleagues colleague NNS cord-320959-sgdqhtns 87 27 concisely concisely RB cord-320959-sgdqhtns 87 28 stated state VBD cord-320959-sgdqhtns 87 29 , , , cord-320959-sgdqhtns 87 30 " " `` cord-320959-sgdqhtns 87 31 because because IN cord-320959-sgdqhtns 87 32 cholesterol cholesterol NN cord-320959-sgdqhtns 87 33 interferes interfere VBZ cord-320959-sgdqhtns 87 34 , , , cord-320959-sgdqhtns 87 35 to to TO cord-320959-sgdqhtns 87 36 detect detect VB cord-320959-sgdqhtns 87 37 a a DT cord-320959-sgdqhtns 87 38 phase phase NN cord-320959-sgdqhtns 87 39 change change NN cord-320959-sgdqhtns 87 40 above above IN cord-320959-sgdqhtns 87 41 the the DT cord-320959-sgdqhtns 87 42 ice ice NN cord-320959-sgdqhtns 87 43 point point NN cord-320959-sgdqhtns 87 44 in in IN cord-320959-sgdqhtns 87 45 a a DT cord-320959-sgdqhtns 87 46 membrane membrane NN cord-320959-sgdqhtns 87 47 , , , cord-320959-sgdqhtns 87 48 an an DT cord-320959-sgdqhtns 87 49 organism organism NN cord-320959-sgdqhtns 87 50 containing contain VBG cord-320959-sgdqhtns 87 51 rather rather RB cord-320959-sgdqhtns 87 52 saturated saturated JJ cord-320959-sgdqhtns 87 53 fatty fatty JJ cord-320959-sgdqhtns 87 54 acids acid NNS cord-320959-sgdqhtns 87 55 but but CC cord-320959-sgdqhtns 87 56 little little JJ cord-320959-sgdqhtns 87 57 or or CC cord-320959-sgdqhtns 87 58 no no DT cord-320959-sgdqhtns 87 59 cholesterol cholesterol NN cord-320959-sgdqhtns 87 60 must must MD cord-320959-sgdqhtns 87 61 be be VB cord-320959-sgdqhtns 87 62 chosen choose VBN cord-320959-sgdqhtns 87 63 " " '' cord-320959-sgdqhtns 87 64 [ [ -LRB- cord-320959-sgdqhtns 87 65 38 38 CD cord-320959-sgdqhtns 87 66 ] ] -RRB- cord-320959-sgdqhtns 87 67 . . . cord-320959-sgdqhtns 88 1 15 15 CD cord-320959-sgdqhtns 88 2 _SP cord-320959-sgdqhtns 89 1 Another another DT cord-320959-sgdqhtns 89 2 important important JJ cord-320959-sgdqhtns 89 3 characteristic characteristic NN cord-320959-sgdqhtns 89 4 of of IN cord-320959-sgdqhtns 89 5 Vitamin vitamin NN cord-320959-sgdqhtns 89 6 E e NN cord-320959-sgdqhtns 89 7 acetate acetate NN cord-320959-sgdqhtns 89 8 in in IN cord-320959-sgdqhtns 89 9 the the DT cord-320959-sgdqhtns 89 10 biological biological JJ cord-320959-sgdqhtns 89 11 system system NN cord-320959-sgdqhtns 89 12 is be VBZ cord-320959-sgdqhtns 89 13 its -PRON- PRP$ cord-320959-sgdqhtns 89 14 deposition deposition NN cord-320959-sgdqhtns 89 15 in in IN cord-320959-sgdqhtns 89 16 lipid lipid NN cord-320959-sgdqhtns 89 17 droplets droplet NNS cord-320959-sgdqhtns 89 18 [ [ -LRB- cord-320959-sgdqhtns 89 19 39 39 CD cord-320959-sgdqhtns 89 20 , , , cord-320959-sgdqhtns 89 21 40 40 CD cord-320959-sgdqhtns 89 22 ] ] -RRB- cord-320959-sgdqhtns 89 23 , , , cord-320959-sgdqhtns 89 24 and and CC cord-320959-sgdqhtns 89 25 many many JJ cord-320959-sgdqhtns 89 26 investigators investigator NNS cord-320959-sgdqhtns 89 27 have have VBP cord-320959-sgdqhtns 89 28 especially especially RB cord-320959-sgdqhtns 89 29 focused focus VBN cord-320959-sgdqhtns 89 30 on on IN cord-320959-sgdqhtns 89 31 the the DT cord-320959-sgdqhtns 89 32 observation observation NN cord-320959-sgdqhtns 89 33 of of IN cord-320959-sgdqhtns 89 34 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 89 35 lipid lipid NN cord-320959-sgdqhtns 89 36 - - HYPH cord-320959-sgdqhtns 89 37 laden laden JJ cord-320959-sgdqhtns 89 38 macrophages macrophage NNS cord-320959-sgdqhtns 89 39 as as IN cord-320959-sgdqhtns 89 40 it -PRON- PRP cord-320959-sgdqhtns 89 41 has have VBZ cord-320959-sgdqhtns 89 42 been be VBN cord-320959-sgdqhtns 89 43 proven prove VBN cord-320959-sgdqhtns 89 44 to to TO cord-320959-sgdqhtns 89 45 be be VB cord-320959-sgdqhtns 89 46 one one CD cord-320959-sgdqhtns 89 47 of of IN cord-320959-sgdqhtns 89 48 the the DT cord-320959-sgdqhtns 89 49 most most RBS cord-320959-sgdqhtns 89 50 prominent prominent JJ cord-320959-sgdqhtns 89 51 20 20 CD cord-320959-sgdqhtns 89 52 features feature NNS cord-320959-sgdqhtns 89 53 of of IN cord-320959-sgdqhtns 89 54 lung lung NN cord-320959-sgdqhtns 89 55 biopsies biopsy NNS cord-320959-sgdqhtns 89 56 from from IN cord-320959-sgdqhtns 89 57 patients patient NNS cord-320959-sgdqhtns 89 58 with with IN cord-320959-sgdqhtns 89 59 EVALI EVALI NNS cord-320959-sgdqhtns 89 60 [ [ -LRB- cord-320959-sgdqhtns 89 61 41 41 CD cord-320959-sgdqhtns 89 62 ] ] -RRB- cord-320959-sgdqhtns 89 63 . . . cord-320959-sgdqhtns 90 1 Indeed indeed RB cord-320959-sgdqhtns 90 2 , , , cord-320959-sgdqhtns 90 3 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 90 4 lipid lipid NN cord-320959-sgdqhtns 90 5 - - HYPH cord-320959-sgdqhtns 90 6 laden laden NN cord-320959-sgdqhtns 90 7 macrophages macrophage NNS cord-320959-sgdqhtns 90 8 were be VBD cord-320959-sgdqhtns 90 9 also also RB cord-320959-sgdqhtns 90 10 evident evident JJ cord-320959-sgdqhtns 90 11 in in IN cord-320959-sgdqhtns 90 12 a a DT cord-320959-sgdqhtns 90 13 murine murine JJ cord-320959-sgdqhtns 90 14 model model NN cord-320959-sgdqhtns 90 15 of of IN cord-320959-sgdqhtns 90 16 Vitamin vitamin NN cord-320959-sgdqhtns 90 17 E e NN cord-320959-sgdqhtns 90 18 acetate acetate NN cord-320959-sgdqhtns 90 19 inhalation inhalation NN cord-320959-sgdqhtns 90 20 ( ( -LRB- cord-320959-sgdqhtns 90 21 daily daily JJ cord-320959-sgdqhtns 90 22 inhalation inhalation NN cord-320959-sgdqhtns 90 23 of of IN cord-320959-sgdqhtns 90 24 77.3 77.3 CD cord-320959-sgdqhtns 90 25 - - SYM cord-320959-sgdqhtns 90 26 167.5 167.5 CD cord-320959-sgdqhtns 90 27 μg μg NNS cord-320959-sgdqhtns 91 1 Vitamin vitamin NN cord-320959-sgdqhtns 91 2 E e NN cord-320959-sgdqhtns 91 3 acetate acetate NN cord-320959-sgdqhtns 91 4 per per IN cord-320959-sgdqhtns 91 5 gram gram NN cord-320959-sgdqhtns 91 6 of of IN cord-320959-sgdqhtns 91 7 body body NN cord-320959-sgdqhtns 91 8 weight weight NN cord-320959-sgdqhtns 91 9 , , , cord-320959-sgdqhtns 91 10 two two CD cord-320959-sgdqhtns 91 11 weeks week NNS cord-320959-sgdqhtns 91 12 of of IN cord-320959-sgdqhtns 91 13 exposure exposure NN cord-320959-sgdqhtns 91 14 ) ) -RRB- cord-320959-sgdqhtns 91 15 , , , cord-320959-sgdqhtns 91 16 of of IN cord-320959-sgdqhtns 91 17 which which WDT cord-320959-sgdqhtns 91 18 effect effect NN cord-320959-sgdqhtns 91 19 was be VBD cord-320959-sgdqhtns 91 20 largely largely RB cord-320959-sgdqhtns 91 21 absent absent JJ cord-320959-sgdqhtns 91 22 in in IN cord-320959-sgdqhtns 91 23 mice mouse NNS cord-320959-sgdqhtns 91 24 inhaled inhale VBD cord-320959-sgdqhtns 91 25 a a DT cord-320959-sgdqhtns 91 26 mixture mixture NN cord-320959-sgdqhtns 91 27 of of IN cord-320959-sgdqhtns 91 28 propylene propylene NN cord-320959-sgdqhtns 91 29 glycol glycol NN cord-320959-sgdqhtns 91 30 and and CC cord-320959-sgdqhtns 91 31 vegetable vegetable NN cord-320959-sgdqhtns 91 32 glycerin glycerin NN cord-320959-sgdqhtns 91 33 [ [ -LRB- cord-320959-sgdqhtns 91 34 42 42 CD cord-320959-sgdqhtns 91 35 ] ] -RRB- cord-320959-sgdqhtns 91 36 . . . cord-320959-sgdqhtns 92 1 Intriguingly intriguingly RB cord-320959-sgdqhtns 92 2 , , , cord-320959-sgdqhtns 92 3 when when WRB cord-320959-sgdqhtns 92 4 a a DT cord-320959-sgdqhtns 92 5 single single JJ cord-320959-sgdqhtns 92 6 dose dose NN cord-320959-sgdqhtns 92 7 of of IN cord-320959-sgdqhtns 92 8 Vitamin vitamin NN cord-320959-sgdqhtns 92 9 E e NN cord-320959-sgdqhtns 92 10 acetate acetate NN cord-320959-sgdqhtns 92 11 ( ( -LRB- cord-320959-sgdqhtns 92 12 inhalation inhalation NN cord-320959-sgdqhtns 92 13 of of IN cord-320959-sgdqhtns 92 14 0.1 0.1 CD cord-320959-sgdqhtns 92 15 μg μg XX cord-320959-sgdqhtns 93 1 Vitamin vitamin NN cord-320959-sgdqhtns 93 2 E e NN cord-320959-sgdqhtns 93 3 acetate acetate NN cord-320959-sgdqhtns 93 4 per per IN cord-320959-sgdqhtns 93 5 gram gram NN cord-320959-sgdqhtns 93 6 of of IN cord-320959-sgdqhtns 93 7 body body NN cord-320959-sgdqhtns 93 8 weight weight NN cord-320959-sgdqhtns 93 9 ) ) -RRB- cord-320959-sgdqhtns 93 10 was be VBD cord-320959-sgdqhtns 93 11 inhaled inhale VBN cord-320959-sgdqhtns 93 12 into into IN cord-320959-sgdqhtns 93 13 the the DT cord-320959-sgdqhtns 93 14 lipopolysaccharide lipopolysaccharide NN cord-320959-sgdqhtns 93 15 - - HYPH cord-320959-sgdqhtns 93 16 treated treat VBN cord-320959-sgdqhtns 93 17 lungs lung NNS cord-320959-sgdqhtns 93 18 of of IN cord-320959-sgdqhtns 93 19 murine murine JJ cord-320959-sgdqhtns 93 20 models model NNS cord-320959-sgdqhtns 93 21 , , , cord-320959-sgdqhtns 93 22 the the DT cord-320959-sgdqhtns 93 23 substance substance NN cord-320959-sgdqhtns 93 24 greatly greatly RB cord-320959-sgdqhtns 93 25 attenuated attenuate VBD cord-320959-sgdqhtns 93 26 the the DT cord-320959-sgdqhtns 93 27 inflammatory inflammatory JJ cord-320959-sgdqhtns 93 28 response response NN cord-320959-sgdqhtns 93 29 , , , cord-320959-sgdqhtns 93 30 despite despite IN cord-320959-sgdqhtns 93 31 being be VBG cord-320959-sgdqhtns 93 32 3-fold 3-fold CD cord-320959-sgdqhtns 93 33 less less RBR cord-320959-sgdqhtns 93 34 potent potent JJ cord-320959-sgdqhtns 93 35 than than IN cord-320959-sgdqhtns 93 36 Vitamin vitamin NN cord-320959-sgdqhtns 93 37 E e NN cord-320959-sgdqhtns 93 38 [ [ -LRB- cord-320959-sgdqhtns 93 39 23 23 CD cord-320959-sgdqhtns 93 40 ] ] -RRB- cord-320959-sgdqhtns 93 41 . . . cord-320959-sgdqhtns 94 1 This this DT cord-320959-sgdqhtns 94 2 indicates indicate VBZ cord-320959-sgdqhtns 94 3 that that IN cord-320959-sgdqhtns 94 4 it -PRON- PRP cord-320959-sgdqhtns 94 5 is be VBZ cord-320959-sgdqhtns 94 6 the the DT cord-320959-sgdqhtns 94 7 excessive excessive JJ cord-320959-sgdqhtns 94 8 accumulation accumulation NN cord-320959-sgdqhtns 94 9 5 5 CD cord-320959-sgdqhtns 94 10 of of IN cord-320959-sgdqhtns 94 11 Vitamin vitamin NN cord-320959-sgdqhtns 94 12 E e NN cord-320959-sgdqhtns 94 13 acetate acetate NN cord-320959-sgdqhtns 94 14 , , , cord-320959-sgdqhtns 94 15 rather rather RB cord-320959-sgdqhtns 94 16 than than IN cord-320959-sgdqhtns 94 17 its -PRON- PRP$ cord-320959-sgdqhtns 94 18 transient transient JJ cord-320959-sgdqhtns 94 19 exposure exposure NN cord-320959-sgdqhtns 94 20 , , , cord-320959-sgdqhtns 94 21 which which WDT cord-320959-sgdqhtns 94 22 is be VBZ cord-320959-sgdqhtns 94 23 responsible responsible JJ cord-320959-sgdqhtns 94 24 for for IN cord-320959-sgdqhtns 94 25 the the DT cord-320959-sgdqhtns 94 26 pathogenesis pathogenesis NN cord-320959-sgdqhtns 94 27 of of IN cord-320959-sgdqhtns 94 28 EVALI EVALI NNS cord-320959-sgdqhtns 94 29 . . . cord-320959-sgdqhtns 95 1 Although although IN cord-320959-sgdqhtns 95 2 it -PRON- PRP cord-320959-sgdqhtns 95 3 is be VBZ cord-320959-sgdqhtns 95 4 tempting tempt VBG cord-320959-sgdqhtns 95 5 to to TO cord-320959-sgdqhtns 95 6 speculate speculate VB cord-320959-sgdqhtns 95 7 that that IN cord-320959-sgdqhtns 95 8 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 95 9 lipid lipid NN cord-320959-sgdqhtns 95 10 - - HYPH cord-320959-sgdqhtns 95 11 laden laden JJ cord-320959-sgdqhtns 95 12 macrophages macrophage NNS cord-320959-sgdqhtns 95 13 observed observe VBN cord-320959-sgdqhtns 95 14 are be VBP cord-320959-sgdqhtns 95 15 merely merely RB cord-320959-sgdqhtns 95 16 the the DT cord-320959-sgdqhtns 95 17 consequence consequence NN cord-320959-sgdqhtns 95 18 of of IN cord-320959-sgdqhtns 95 19 excessive excessive JJ cord-320959-sgdqhtns 95 20 deposition deposition NN cord-320959-sgdqhtns 95 21 of of IN cord-320959-sgdqhtns 95 22 Vitamin vitamin NN cord-320959-sgdqhtns 95 23 E e NN cord-320959-sgdqhtns 95 24 acetate acetate NN cord-320959-sgdqhtns 95 25 within within IN cord-320959-sgdqhtns 95 26 the the DT cord-320959-sgdqhtns 95 27 pulmonary pulmonary JJ cord-320959-sgdqhtns 95 28 system system NN cord-320959-sgdqhtns 95 29 , , , cord-320959-sgdqhtns 95 30 increasing increase VBG cord-320959-sgdqhtns 95 31 amount amount NN cord-320959-sgdqhtns 95 32 of of IN cord-320959-sgdqhtns 95 33 reports report NNS cord-320959-sgdqhtns 95 34 suggest suggest VBP cord-320959-sgdqhtns 95 35 that that IN cord-320959-sgdqhtns 95 36 such such JJ cord-320959-sgdqhtns 95 37 assumptions assumption NNS cord-320959-sgdqhtns 95 38 are be VBP cord-320959-sgdqhtns 95 39 erroneous erroneous JJ cord-320959-sgdqhtns 95 40 . . . cord-320959-sgdqhtns 96 1 Importantly importantly RB cord-320959-sgdqhtns 96 2 , , , cord-320959-sgdqhtns 96 3 10 10 CD cord-320959-sgdqhtns 96 4 there there EX cord-320959-sgdqhtns 96 5 is be VBZ cord-320959-sgdqhtns 96 6 a a DT cord-320959-sgdqhtns 96 7 lacking lack VBG cord-320959-sgdqhtns 96 8 histological histological JJ cord-320959-sgdqhtns 96 9 evidence evidence NN cord-320959-sgdqhtns 96 10 of of IN cord-320959-sgdqhtns 96 11 exogenous exogenous JJ cord-320959-sgdqhtns 96 12 lipoid lipoid NNP cord-320959-sgdqhtns 96 13 pneumonia pneumonia NN cord-320959-sgdqhtns 96 14 ( ( -LRB- cord-320959-sgdqhtns 96 15 ELP ELP NNP cord-320959-sgdqhtns 96 16 ) ) -RRB- cord-320959-sgdqhtns 96 17 in in IN cord-320959-sgdqhtns 96 18 patients patient NNS cord-320959-sgdqhtns 96 19 suffering suffer VBG cord-320959-sgdqhtns 96 20 from from IN cord-320959-sgdqhtns 96 21 EVALI EVALI NNP cord-320959-sgdqhtns 96 22 , , , cord-320959-sgdqhtns 96 23 despite despite IN cord-320959-sgdqhtns 96 24 the the DT cord-320959-sgdqhtns 96 25 prevalence prevalence NN cord-320959-sgdqhtns 96 26 of of IN cord-320959-sgdqhtns 96 27 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 96 28 lipid lipid NN cord-320959-sgdqhtns 96 29 - - HYPH cord-320959-sgdqhtns 96 30 laden laden JJ cord-320959-sgdqhtns 96 31 macrophages macrophage NNS cord-320959-sgdqhtns 96 32 in in IN cord-320959-sgdqhtns 96 33 BAL bal NN cord-320959-sgdqhtns 96 34 fluids fluid NNS cord-320959-sgdqhtns 96 35 . . . cord-320959-sgdqhtns 97 1 For for IN cord-320959-sgdqhtns 97 2 instance instance NN cord-320959-sgdqhtns 97 3 , , , cord-320959-sgdqhtns 97 4 when when WRB cord-320959-sgdqhtns 97 5 a a DT cord-320959-sgdqhtns 97 6 63-year 63-year JJ cord-320959-sgdqhtns 97 7 - - HYPH cord-320959-sgdqhtns 97 8 old old JJ cord-320959-sgdqhtns 97 9 woman woman NN cord-320959-sgdqhtns 97 10 had have VBD cord-320959-sgdqhtns 97 11 regularly regularly RB cord-320959-sgdqhtns 97 12 smoked smoke VBN cord-320959-sgdqhtns 97 13 cod cod NN cord-320959-sgdqhtns 97 14 - - HYPH cord-320959-sgdqhtns 97 15 liver liver NN cord-320959-sgdqhtns 97 16 oil oil NN cord-320959-sgdqhtns 97 17 , , , cord-320959-sgdqhtns 97 18 she -PRON- PRP cord-320959-sgdqhtns 97 19 acquired acquire VBD cord-320959-sgdqhtns 97 20 a a DT cord-320959-sgdqhtns 97 21 non non JJ cord-320959-sgdqhtns 97 22 - - JJ cord-320959-sgdqhtns 97 23 oncologic oncologic JJ cord-320959-sgdqhtns 97 24 perihilar perihilar NNP cord-320959-sgdqhtns 97 25 mass mass NNP cord-320959-sgdqhtns 97 26 in in IN cord-320959-sgdqhtns 97 27 the the DT cord-320959-sgdqhtns 97 28 right right JJ cord-320959-sgdqhtns 97 29 middle middle JJ cord-320959-sgdqhtns 97 30 lobe lobe NN cord-320959-sgdqhtns 97 31 of of IN cord-320959-sgdqhtns 97 32 her -PRON- PRP$ cord-320959-sgdqhtns 97 33 lung lung NN cord-320959-sgdqhtns 97 34 , , , cord-320959-sgdqhtns 97 35 indicative indicative JJ cord-320959-sgdqhtns 97 36 of of IN cord-320959-sgdqhtns 97 37 ELP ELP NNP cord-320959-sgdqhtns 97 38 [ [ -LRB- cord-320959-sgdqhtns 97 39 43 43 CD cord-320959-sgdqhtns 97 40 ] ] -RRB- cord-320959-sgdqhtns 97 41 , , , cord-320959-sgdqhtns 97 42 but but CC cord-320959-sgdqhtns 97 43 these these DT cord-320959-sgdqhtns 97 44 ELP ELP NNP cord-320959-sgdqhtns 97 45 - - HYPH cord-320959-sgdqhtns 97 46 like like JJ cord-320959-sgdqhtns 97 47 histological histological JJ cord-320959-sgdqhtns 97 48 signs sign NNS cord-320959-sgdqhtns 97 49 were be VBD cord-320959-sgdqhtns 97 50 mostly mostly RB cord-320959-sgdqhtns 97 51 absent absent JJ cord-320959-sgdqhtns 97 52 in in IN cord-320959-sgdqhtns 97 53 patients patient NNS cord-320959-sgdqhtns 97 54 with with IN cord-320959-sgdqhtns 97 55 EVALI EVALI NNS cord-320959-sgdqhtns 97 56 [ [ -LRB- cord-320959-sgdqhtns 97 57 11 11 CD cord-320959-sgdqhtns 97 58 ] ] -RRB- cord-320959-sgdqhtns 97 59 . . . cord-320959-sgdqhtns 98 1 As as IN cord-320959-sgdqhtns 98 2 Guerrini Guerrini NNP cord-320959-sgdqhtns 98 3 15 15 CD cord-320959-sgdqhtns 98 4 and and CC cord-320959-sgdqhtns 98 5 colleagues colleague NNS cord-320959-sgdqhtns 98 6 importantly importantly RB cord-320959-sgdqhtns 98 7 mention mention VBP cord-320959-sgdqhtns 98 8 , , , cord-320959-sgdqhtns 98 9 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 98 10 lipid lipid NN cord-320959-sgdqhtns 98 11 - - HYPH cord-320959-sgdqhtns 98 12 laden laden NN cord-320959-sgdqhtns 98 13 macrophages macrophage NNS cord-320959-sgdqhtns 98 14 do do VBP cord-320959-sgdqhtns 98 15 not not RB cord-320959-sgdqhtns 98 16 always always RB cord-320959-sgdqhtns 98 17 originate originate VB cord-320959-sgdqhtns 98 18 from from IN cord-320959-sgdqhtns 98 19 an an DT cord-320959-sgdqhtns 98 20 excessive excessive JJ cord-320959-sgdqhtns 98 21 uptake uptake NN cord-320959-sgdqhtns 98 22 of of IN cord-320959-sgdqhtns 98 23 exogenous exogenous JJ cord-320959-sgdqhtns 98 24 lipids lipid NNS cord-320959-sgdqhtns 98 25 , , , cord-320959-sgdqhtns 98 26 but but CC cord-320959-sgdqhtns 98 27 may may MD cord-320959-sgdqhtns 98 28 often often RB cord-320959-sgdqhtns 98 29 emerge emerge VB cord-320959-sgdqhtns 98 30 as as IN cord-320959-sgdqhtns 98 31 a a DT cord-320959-sgdqhtns 98 32 common common JJ cord-320959-sgdqhtns 98 33 immunopathological immunopathological JJ cord-320959-sgdqhtns 98 34 response response NN cord-320959-sgdqhtns 98 35 following follow VBG cord-320959-sgdqhtns 98 36 sustained sustained JJ cord-320959-sgdqhtns 98 37 inflammation inflammation NN cord-320959-sgdqhtns 98 38 [ [ -LRB- cord-320959-sgdqhtns 98 39 44 44 CD cord-320959-sgdqhtns 98 40 ] ] -RRB- cord-320959-sgdqhtns 98 41 . . . cord-320959-sgdqhtns 99 1 However however RB cord-320959-sgdqhtns 99 2 , , , cord-320959-sgdqhtns 99 3 unmodified unmodified JJ cord-320959-sgdqhtns 99 4 Vitamin vitamin NN cord-320959-sgdqhtns 99 5 E e NN cord-320959-sgdqhtns 99 6 is be VBZ cord-320959-sgdqhtns 99 7 indicated indicate VBN cord-320959-sgdqhtns 99 8 in in IN cord-320959-sgdqhtns 99 9 the the DT cord-320959-sgdqhtns 99 10 downregulation downregulation NN cord-320959-sgdqhtns 99 11 of of IN cord-320959-sgdqhtns 99 12 CD36 CD36 NNP cord-320959-sgdqhtns 99 13 [ [ -LRB- cord-320959-sgdqhtns 99 14 45 45 CD cord-320959-sgdqhtns 99 15 ] ] -RRB- cord-320959-sgdqhtns 99 16 , , , cord-320959-sgdqhtns 99 17 which which WDT cord-320959-sgdqhtns 99 18 functions function VBZ cord-320959-sgdqhtns 99 19 to to TO cord-320959-sgdqhtns 99 20 promote promote VB cord-320959-sgdqhtns 99 21 the the DT cord-320959-sgdqhtns 99 22 formation formation NN cord-320959-sgdqhtns 99 23 of of IN cord-320959-sgdqhtns 99 24 lipid lipid NN cord-320959-sgdqhtns 99 25 - - HYPH cord-320959-sgdqhtns 99 26 laden laden NN cord-320959-sgdqhtns 99 27 macrophages macrophage NNS cord-320959-sgdqhtns 99 28 ( ( -LRB- cord-320959-sgdqhtns 99 29 foam foam NN cord-320959-sgdqhtns 99 30 cells cell NNS cord-320959-sgdqhtns 99 31 ) ) -RRB- cord-320959-sgdqhtns 100 1 [ [ -LRB- cord-320959-sgdqhtns 100 2 46 46 CD cord-320959-sgdqhtns 100 3 ] ] -RRB- cord-320959-sgdqhtns 100 4 . . . cord-320959-sgdqhtns 101 1 Furthermore furthermore RB cord-320959-sgdqhtns 101 2 , , , cord-320959-sgdqhtns 101 3 Vitamin vitamin NN cord-320959-sgdqhtns 101 4 E e NN cord-320959-sgdqhtns 101 5 also also RB cord-320959-sgdqhtns 101 6 ameliorates ameliorate VBZ cord-320959-sgdqhtns 101 7 This this DT cord-320959-sgdqhtns 101 8 hypothesis hypothesis NN cord-320959-sgdqhtns 101 9 also also RB cord-320959-sgdqhtns 101 10 does do VBZ cord-320959-sgdqhtns 101 11 not not RB cord-320959-sgdqhtns 101 12 provide provide VB cord-320959-sgdqhtns 101 13 us -PRON- PRP cord-320959-sgdqhtns 101 14 with with IN cord-320959-sgdqhtns 101 15 an an DT cord-320959-sgdqhtns 101 16 exact exact JJ cord-320959-sgdqhtns 101 17 mechanism mechanism NN cord-320959-sgdqhtns 101 18 by by IN cord-320959-sgdqhtns 101 19 which which WDT cord-320959-sgdqhtns 101 20 Vitamin vitamin NN cord-320959-sgdqhtns 101 21 E e NN cord-320959-sgdqhtns 101 22 acetate acetate NN cord-320959-sgdqhtns 101 23 may may MD cord-320959-sgdqhtns 101 24 initiate initiate VB cord-320959-sgdqhtns 101 25 inflammation inflammation NN cord-320959-sgdqhtns 101 26 . . . cord-320959-sgdqhtns 102 1 Since since IN cord-320959-sgdqhtns 102 2 Vitamin vitamin NN cord-320959-sgdqhtns 102 3 E e NN cord-320959-sgdqhtns 102 4 acetate acetate NN cord-320959-sgdqhtns 102 5 is be VBZ cord-320959-sgdqhtns 102 6 a a DT cord-320959-sgdqhtns 102 7 viscous viscous JJ cord-320959-sgdqhtns 102 8 liquid liquid NN cord-320959-sgdqhtns 102 9 at at IN cord-320959-sgdqhtns 102 10 physiological physiological JJ cord-320959-sgdqhtns 102 11 temperature temperature NN cord-320959-sgdqhtns 102 12 , , , cord-320959-sgdqhtns 102 13 activation activation NN cord-320959-sgdqhtns 102 14 of of IN cord-320959-sgdqhtns 102 15 the the DT cord-320959-sgdqhtns 102 16 NLRP3 NLRP3 NNP cord-320959-sgdqhtns 102 17 inflammasome inflammasome NNP cord-320959-sgdqhtns 102 18 through through IN cord-320959-sgdqhtns 102 19 crystal crystal NN cord-320959-sgdqhtns 102 20 - - HYPH cord-320959-sgdqhtns 102 21 induced induce VBN cord-320959-sgdqhtns 102 22 lysosomal lysosomal JJ cord-320959-sgdqhtns 102 23 rupture rupture NN cord-320959-sgdqhtns 102 24 as as IN cord-320959-sgdqhtns 102 25 in in IN cord-320959-sgdqhtns 102 26 models model NNS cord-320959-sgdqhtns 102 27 of of IN cord-320959-sgdqhtns 102 28 silicosis silicosis NN cord-320959-sgdqhtns 102 29 [ [ -LRB- cord-320959-sgdqhtns 102 30 48 48 CD cord-320959-sgdqhtns 102 31 ] ] -RRB- cord-320959-sgdqhtns 102 32 seems seem VBZ cord-320959-sgdqhtns 102 33 unlikely unlikely JJ cord-320959-sgdqhtns 102 34 , , , cord-320959-sgdqhtns 102 35 despite despite IN cord-320959-sgdqhtns 102 36 robust robust JJ cord-320959-sgdqhtns 102 37 activation activation NN cord-320959-sgdqhtns 102 38 of of IN cord-320959-sgdqhtns 102 39 the the DT cord-320959-sgdqhtns 102 40 inflammasome inflammasome NN cord-320959-sgdqhtns 102 41 in in IN cord-320959-sgdqhtns 102 42 e- e- XX cord-320959-sgdqhtns 102 43 5 5 CD cord-320959-sgdqhtns 102 44 cigarette cigarette NN cord-320959-sgdqhtns 102 45 users user NNS cord-320959-sgdqhtns 102 46 [ [ -LRB- cord-320959-sgdqhtns 102 47 49 49 CD cord-320959-sgdqhtns 102 48 ] ] -RRB- cord-320959-sgdqhtns 102 49 . . . cord-320959-sgdqhtns 103 1 Vitamin vitamin NN cord-320959-sgdqhtns 103 2 E e NN cord-320959-sgdqhtns 103 3 is be VBZ cord-320959-sgdqhtns 103 4 also also RB cord-320959-sgdqhtns 103 5 indicated indicate VBN cord-320959-sgdqhtns 103 6 in in IN cord-320959-sgdqhtns 103 7 an an DT cord-320959-sgdqhtns 103 8 active active JJ cord-320959-sgdqhtns 103 9 inhibition inhibition NN cord-320959-sgdqhtns 103 10 of of IN cord-320959-sgdqhtns 103 11 5-lipoxygenase 5-lipoxygenase CD cord-320959-sgdqhtns 103 12 ( ( -LRB- cord-320959-sgdqhtns 103 13 5-LO 5-lo CD cord-320959-sgdqhtns 103 14 ) ) -RRB- cord-320959-sgdqhtns 103 15 , , , cord-320959-sgdqhtns 103 16 which which WDT cord-320959-sgdqhtns 103 17 converts convert VBZ cord-320959-sgdqhtns 103 18 fatty fatty JJ cord-320959-sgdqhtns 103 19 acids acid NNS cord-320959-sgdqhtns 103 20 to to IN cord-320959-sgdqhtns 103 21 leukotrienes leukotriene NNS cord-320959-sgdqhtns 103 22 , , , cord-320959-sgdqhtns 103 23 promoting promote VBG cord-320959-sgdqhtns 103 24 inflammation inflammation NN cord-320959-sgdqhtns 103 25 [ [ -LRB- cord-320959-sgdqhtns 103 26 50 50 CD cord-320959-sgdqhtns 103 27 , , , cord-320959-sgdqhtns 103 28 51 51 CD cord-320959-sgdqhtns 103 29 ] ] -RRB- cord-320959-sgdqhtns 103 30 . . . cord-320959-sgdqhtns 104 1 Importantly importantly RB cord-320959-sgdqhtns 104 2 , , , cord-320959-sgdqhtns 104 3 Vitamin vitamin NN cord-320959-sgdqhtns 104 4 E e NN cord-320959-sgdqhtns 104 5 acetate acetate NN cord-320959-sgdqhtns 104 6 is be VBZ cord-320959-sgdqhtns 104 7 also also RB cord-320959-sgdqhtns 104 8 reported report VBN cord-320959-sgdqhtns 104 9 to to TO cord-320959-sgdqhtns 104 10 inhibit inhibit VB cord-320959-sgdqhtns 104 11 5-LO 5-lo CD cord-320959-sgdqhtns 104 12 activity activity NN cord-320959-sgdqhtns 104 13 [ [ -LRB- cord-320959-sgdqhtns 104 14 50 50 CD cord-320959-sgdqhtns 104 15 ] ] -RRB- cord-320959-sgdqhtns 104 16 , , , cord-320959-sgdqhtns 104 17 despite despite IN cord-320959-sgdqhtns 104 18 being be VBG cord-320959-sgdqhtns 104 19 twice twice RB cord-320959-sgdqhtns 104 20 less less RBR cord-320959-sgdqhtns 104 21 potent potent JJ cord-320959-sgdqhtns 104 22 than than IN cord-320959-sgdqhtns 104 23 the the DT cord-320959-sgdqhtns 104 24 unmodified unmodified JJ cord-320959-sgdqhtns 104 25 vitamin vitamin NN cord-320959-sgdqhtns 104 26 , , , cord-320959-sgdqhtns 104 27 supporting support VBG cord-320959-sgdqhtns 104 28 the the DT cord-320959-sgdqhtns 104 29 view view NN cord-320959-sgdqhtns 104 30 that that IN cord-320959-sgdqhtns 104 31 Vitamin vitamin NN cord-320959-sgdqhtns 104 32 E e NN cord-320959-sgdqhtns 104 33 acetate acetate NN cord-320959-sgdqhtns 104 34 does do VBZ cord-320959-sgdqhtns 104 35 not not RB cord-320959-sgdqhtns 104 36 induce induce VB cord-320959-sgdqhtns 104 37 ELP ELP NNP cord-320959-sgdqhtns 104 38 in in IN cord-320959-sgdqhtns 104 39 patients patient NNS cord-320959-sgdqhtns 104 40 with with IN cord-320959-sgdqhtns 104 41 EVALI EVALI NNS cord-320959-sgdqhtns 104 42 via via IN cord-320959-sgdqhtns 104 43 the the DT cord-320959-sgdqhtns 104 44 inflammatory inflammatory JJ cord-320959-sgdqhtns 104 45 response response NN cord-320959-sgdqhtns 104 46 . . . cord-320959-sgdqhtns 105 1 10 10 CD cord-320959-sgdqhtns 105 2 _SP cord-320959-sgdqhtns 106 1 In in IN cord-320959-sgdqhtns 106 2 the the DT cord-320959-sgdqhtns 106 3 field field NN cord-320959-sgdqhtns 106 4 of of IN cord-320959-sgdqhtns 106 5 diabetes diabetes NN cord-320959-sgdqhtns 106 6 mellitus mellitus NN cord-320959-sgdqhtns 106 7 , , , cord-320959-sgdqhtns 106 8 Vitamin vitamin NN cord-320959-sgdqhtns 106 9 E e NN cord-320959-sgdqhtns 106 10 is be VBZ cord-320959-sgdqhtns 106 11 a a DT cord-320959-sgdqhtns 106 12 potent potent JJ cord-320959-sgdqhtns 106 13 agonist agonist NN cord-320959-sgdqhtns 106 14 of of IN cord-320959-sgdqhtns 106 15 DGKα DGKα NNS cord-320959-sgdqhtns 106 16 , , , cord-320959-sgdqhtns 106 17 which which WDT cord-320959-sgdqhtns 106 18 catalyzes catalyze VBZ cord-320959-sgdqhtns 106 19 the the DT cord-320959-sgdqhtns 106 20 conversion conversion NN cord-320959-sgdqhtns 106 21 of of IN cord-320959-sgdqhtns 106 22 diacylglycerol diacylglycerol NN cord-320959-sgdqhtns 106 23 ( ( -LRB- cord-320959-sgdqhtns 106 24 DAG DAG NNP cord-320959-sgdqhtns 106 25 ) ) -RRB- cord-320959-sgdqhtns 106 26 to to IN cord-320959-sgdqhtns 106 27 phosphatidic phosphatidic JJ cord-320959-sgdqhtns 106 28 acid acid NNP cord-320959-sgdqhtns 106 29 ( ( -LRB- cord-320959-sgdqhtns 106 30 PA PA NNP cord-320959-sgdqhtns 106 31 ) ) -RRB- cord-320959-sgdqhtns 106 32 and and CC cord-320959-sgdqhtns 106 33 thereby thereby RB cord-320959-sgdqhtns 106 34 inhibits inhibit VBZ cord-320959-sgdqhtns 106 35 the the DT cord-320959-sgdqhtns 106 36 catalytic catalytic JJ cord-320959-sgdqhtns 106 37 activity activity NN cord-320959-sgdqhtns 106 38 of of IN cord-320959-sgdqhtns 106 39 PKCα PKCα NNS cord-320959-sgdqhtns 106 40 [ [ -LRB- cord-320959-sgdqhtns 106 41 52 52 CD cord-320959-sgdqhtns 106 42 ] ] -RRB- cord-320959-sgdqhtns 107 1 [ [ -LRB- cord-320959-sgdqhtns 107 2 53 53 CD cord-320959-sgdqhtns 107 3 ] ] -RRB- cord-320959-sgdqhtns 107 4 [ [ -LRB- cord-320959-sgdqhtns 107 5 54 54 CD cord-320959-sgdqhtns 107 6 ] ] -RRB- cord-320959-sgdqhtns 107 7 . . . cord-320959-sgdqhtns 108 1 Agonism agonism NN cord-320959-sgdqhtns 108 2 of of IN cord-320959-sgdqhtns 108 3 DGKα DGKα NNS cord-320959-sgdqhtns 108 4 by by IN cord-320959-sgdqhtns 108 5 Vitamin vitamin NN cord-320959-sgdqhtns 108 6 E e NN cord-320959-sgdqhtns 108 7 derivatives derivative NNS cord-320959-sgdqhtns 108 8 are be VBP cord-320959-sgdqhtns 108 9 known know VBN cord-320959-sgdqhtns 108 10 to to TO cord-320959-sgdqhtns 108 11 be be VB cord-320959-sgdqhtns 108 12 15 15 CD cord-320959-sgdqhtns 108 13 dependent dependent JJ cord-320959-sgdqhtns 108 14 on on IN cord-320959-sgdqhtns 108 15 the the DT cord-320959-sgdqhtns 108 16 chromane chromane NN cord-320959-sgdqhtns 108 17 double double JJ cord-320959-sgdqhtns 108 18 ring ring NN cord-320959-sgdqhtns 108 19 of of IN cord-320959-sgdqhtns 108 20 the the DT cord-320959-sgdqhtns 108 21 molecule molecule NN cord-320959-sgdqhtns 108 22 , , , cord-320959-sgdqhtns 108 23 as as IN cord-320959-sgdqhtns 108 24 both both CC cord-320959-sgdqhtns 108 25 Vitamin vitamin NN cord-320959-sgdqhtns 108 26 E e NN cord-320959-sgdqhtns 108 27 analogs analog NNS cord-320959-sgdqhtns 108 28 containing contain VBG cord-320959-sgdqhtns 108 29 the the DT cord-320959-sgdqhtns 108 30 moiety moiety NN cord-320959-sgdqhtns 108 31 , , , cord-320959-sgdqhtns 108 32 such such JJ cord-320959-sgdqhtns 108 33 as as IN cord-320959-sgdqhtns 108 34 troglitazone troglitazone NNP cord-320959-sgdqhtns 108 35 and and CC cord-320959-sgdqhtns 108 36 trolox trolox NNP cord-320959-sgdqhtns 108 37 , , , cord-320959-sgdqhtns 108 38 and and CC cord-320959-sgdqhtns 108 39 non non JJ cord-320959-sgdqhtns 108 40 - - JJ cord-320959-sgdqhtns 108 41 antioxidative antioxidative JJ cord-320959-sgdqhtns 108 42 Vitamin vitamin NN cord-320959-sgdqhtns 108 43 E e NN cord-320959-sgdqhtns 108 44 derivatives derivative NNS cord-320959-sgdqhtns 108 45 , , , cord-320959-sgdqhtns 108 46 such such JJ cord-320959-sgdqhtns 108 47 as as IN cord-320959-sgdqhtns 108 48 Vitamin vitamin NN cord-320959-sgdqhtns 108 49 E e NN cord-320959-sgdqhtns 108 50 succinate succinate NN cord-320959-sgdqhtns 108 51 , , , cord-320959-sgdqhtns 108 52 exhibited exhibit VBD cord-320959-sgdqhtns 108 53 robust robust JJ cord-320959-sgdqhtns 108 54 activation activation NN cord-320959-sgdqhtns 108 55 and and CC cord-320959-sgdqhtns 108 56 subsequent subsequent JJ cord-320959-sgdqhtns 108 57 plasmalemmal plasmalemmal JJ cord-320959-sgdqhtns 108 58 translocation translocation NN cord-320959-sgdqhtns 108 59 of of IN cord-320959-sgdqhtns 108 60 the the DT cord-320959-sgdqhtns 108 61 kinase kinase NN cord-320959-sgdqhtns 108 62 [ [ -LRB- cord-320959-sgdqhtns 108 63 55 55 CD cord-320959-sgdqhtns 108 64 ] ] -RRB- cord-320959-sgdqhtns 108 65 . . . cord-320959-sgdqhtns 109 1 Vitamin vitamin NN cord-320959-sgdqhtns 109 2 E e NN cord-320959-sgdqhtns 109 3 acetate acetate NN cord-320959-sgdqhtns 109 4 may may MD cord-320959-sgdqhtns 109 5 also also RB cord-320959-sgdqhtns 109 6 antagonize antagonize VB cord-320959-sgdqhtns 109 7 the the DT cord-320959-sgdqhtns 109 8 catalytic catalytic JJ cord-320959-sgdqhtns 109 9 activity activity NN cord-320959-sgdqhtns 109 10 of of IN cord-320959-sgdqhtns 109 11 PKCα PKCα NNS cord-320959-sgdqhtns 109 12 in in IN cord-320959-sgdqhtns 109 13 a a DT cord-320959-sgdqhtns 109 14 DGKindependent dgkindependent JJ cord-320959-sgdqhtns 109 15 manner manner NN cord-320959-sgdqhtns 109 16 , , , cord-320959-sgdqhtns 109 17 as as IN cord-320959-sgdqhtns 109 18 there there EX cord-320959-sgdqhtns 109 19 are be VBP cord-320959-sgdqhtns 109 20 studies study NNS cord-320959-sgdqhtns 109 21 indicating indicate VBG cord-320959-sgdqhtns 109 22 that that IN cord-320959-sgdqhtns 109 23 the the DT cord-320959-sgdqhtns 109 24 substance substance NN cord-320959-sgdqhtns 109 25 is be VBZ cord-320959-sgdqhtns 109 26 capable capable JJ cord-320959-sgdqhtns 109 27 of of IN cord-320959-sgdqhtns 109 28 competing compete VBG cord-320959-sgdqhtns 109 29 20 20 CD cord-320959-sgdqhtns 109 30 with with IN cord-320959-sgdqhtns 109 31 DAG DAG NNP cord-320959-sgdqhtns 109 32 for for IN cord-320959-sgdqhtns 109 33 its -PRON- PRP$ cord-320959-sgdqhtns 109 34 binding binding NN cord-320959-sgdqhtns 109 35 site site NN cord-320959-sgdqhtns 109 36 in in IN cord-320959-sgdqhtns 109 37 PKCα PKCα NNS cord-320959-sgdqhtns 109 38 [ [ -LRB- cord-320959-sgdqhtns 109 39 56 56 CD cord-320959-sgdqhtns 109 40 ] ] -RRB- cord-320959-sgdqhtns 109 41 . . . cord-320959-sgdqhtns 110 1 Intriguingly intriguingly RB cord-320959-sgdqhtns 110 2 , , , cord-320959-sgdqhtns 110 3 d d LS cord-320959-sgdqhtns 110 4 - - HYPH cord-320959-sgdqhtns 110 5 α α NN cord-320959-sgdqhtns 110 6 - - HYPH cord-320959-sgdqhtns 110 7 tocopherol tocopherol NN cord-320959-sgdqhtns 110 8 , , , cord-320959-sgdqhtns 110 9 but but CC cord-320959-sgdqhtns 110 10 not not RB cord-320959-sgdqhtns 110 11 d d NN cord-320959-sgdqhtns 110 12 - - HYPH cord-320959-sgdqhtns 110 13 β β NN cord-320959-sgdqhtns 110 14 - - HYPH cord-320959-sgdqhtns 110 15 tocopherol tocopherol NN cord-320959-sgdqhtns 110 16 nor nor CC cord-320959-sgdqhtns 110 17 d d NN cord-320959-sgdqhtns 110 18 - - HYPH cord-320959-sgdqhtns 110 19 γ γ NN cord-320959-sgdqhtns 110 20 - - HYPH cord-320959-sgdqhtns 110 21 tocopherol tocopherol NN cord-320959-sgdqhtns 110 22 exhibited exhibit VBD cord-320959-sgdqhtns 110 23 robust robust JJ cord-320959-sgdqhtns 110 24 inactivation inactivation NN cord-320959-sgdqhtns 110 25 of of IN cord-320959-sgdqhtns 110 26 PKCα PKCα NNS cord-320959-sgdqhtns 110 27 , , , cord-320959-sgdqhtns 110 28 indicating indicate VBG cord-320959-sgdqhtns 110 29 a a DT cord-320959-sgdqhtns 110 30 pivotal pivotal JJ cord-320959-sgdqhtns 110 31 role role NN cord-320959-sgdqhtns 110 32 of of IN cord-320959-sgdqhtns 110 33 methylation methylation NN cord-320959-sgdqhtns 110 34 at at IN cord-320959-sgdqhtns 110 35 C5 C5 NNP cord-320959-sgdqhtns 110 36 and and CC cord-320959-sgdqhtns 110 37 C7 C7 NNP cord-320959-sgdqhtns 110 38 of of IN cord-320959-sgdqhtns 110 39 the the DT cord-320959-sgdqhtns 110 40 chromanol chromanol NNP cord-320959-sgdqhtns 110 41 structure structure NN cord-320959-sgdqhtns 110 42 [ [ -LRB- cord-320959-sgdqhtns 110 43 57 57 CD cord-320959-sgdqhtns 110 44 ] ] -RRB- cord-320959-sgdqhtns 110 45 . . . cord-320959-sgdqhtns 111 1 Supplementation supplementation NN cord-320959-sgdqhtns 111 2 of of IN cord-320959-sgdqhtns 111 3 Vitamin vitamin NN cord-320959-sgdqhtns 111 4 E e NN cord-320959-sgdqhtns 111 5 acetate acetate NN cord-320959-sgdqhtns 111 6 in in IN cord-320959-sgdqhtns 111 7 murine murine JJ cord-320959-sgdqhtns 111 8 models model NNS cord-320959-sgdqhtns 111 9 of of IN cord-320959-sgdqhtns 111 10 diabetic diabetic JJ cord-320959-sgdqhtns 111 11 cardiomyopathy cardiomyopathy NN cord-320959-sgdqhtns 111 12 showed show VBD cord-320959-sgdqhtns 111 13 largely largely RB cord-320959-sgdqhtns 111 14 protective protective JJ cord-320959-sgdqhtns 111 15 role role NN cord-320959-sgdqhtns 111 16 for for IN cord-320959-sgdqhtns 111 17 the the DT cord-320959-sgdqhtns 111 18 chemical chemical NN cord-320959-sgdqhtns 111 19 [ [ -LRB- cord-320959-sgdqhtns 111 20 58 58 CD cord-320959-sgdqhtns 111 21 ] ] -RRB- cord-320959-sgdqhtns 111 22 , , , cord-320959-sgdqhtns 111 23 but but CC cord-320959-sgdqhtns 111 24 it -PRON- PRP cord-320959-sgdqhtns 111 25 is be VBZ cord-320959-sgdqhtns 111 26 worth worth JJ cord-320959-sgdqhtns 111 27 to to TO cord-320959-sgdqhtns 111 28 note note VB cord-320959-sgdqhtns 111 29 that that IN cord-320959-sgdqhtns 111 30 most most JJS cord-320959-sgdqhtns 111 31 of of IN cord-320959-sgdqhtns 111 32 the the DT cord-320959-sgdqhtns 111 33 substances substance NNS cord-320959-sgdqhtns 111 34 supplemented supplement VBN cord-320959-sgdqhtns 111 35 via via IN cord-320959-sgdqhtns 111 36 dietary dietary JJ cord-320959-sgdqhtns 111 37 uptake uptake NN cord-320959-sgdqhtns 111 38 undergo undergo VBP cord-320959-sgdqhtns 111 39 hydrolysis hydrolysis NN cord-320959-sgdqhtns 111 40 to to TO cord-320959-sgdqhtns 111 41 yield yield VB cord-320959-sgdqhtns 111 42 Vitamin vitamin NN cord-320959-sgdqhtns 111 43 E. E. NNP cord-320959-sgdqhtns 112 1 The the DT cord-320959-sgdqhtns 112 2 protective protective JJ cord-320959-sgdqhtns 112 3 effect effect NN cord-320959-sgdqhtns 112 4 of of IN cord-320959-sgdqhtns 112 5 Vitamin vitamin NN cord-320959-sgdqhtns 112 6 E e NN cord-320959-sgdqhtns 112 7 derivatives derivative NNS cord-320959-sgdqhtns 112 8 in in IN cord-320959-sgdqhtns 112 9 diabetes diabetes NN cord-320959-sgdqhtns 112 10 mellitus mellitus NN cord-320959-sgdqhtns 112 11 was be VBD cord-320959-sgdqhtns 112 12 completely completely RB cord-320959-sgdqhtns 112 13 ameliorated ameliorate VBN cord-320959-sgdqhtns 112 14 in in IN cord-320959-sgdqhtns 112 15 DGKα dgkα NN cord-320959-sgdqhtns 112 16 knockout knockout NN cord-320959-sgdqhtns 112 17 mice mouse NNS cord-320959-sgdqhtns 112 18 , , , cord-320959-sgdqhtns 112 19 indicating indicate VBG cord-320959-sgdqhtns 112 20 a a DT cord-320959-sgdqhtns 112 21 pivotal pivotal JJ cord-320959-sgdqhtns 112 22 role role NN cord-320959-sgdqhtns 112 23 of of IN cord-320959-sgdqhtns 112 24 the the DT cord-320959-sgdqhtns 112 25 kinase kinase NN cord-320959-sgdqhtns 112 26 in in IN cord-320959-sgdqhtns 112 27 this this DT cord-320959-sgdqhtns 112 28 antidiabetic antidiabetic JJ cord-320959-sgdqhtns 112 29 signaling signal VBG cord-320959-sgdqhtns 112 30 cascade cascade NN cord-320959-sgdqhtns 112 31 [ [ -LRB- cord-320959-sgdqhtns 112 32 54 54 CD cord-320959-sgdqhtns 112 33 ] ] -RRB- cord-320959-sgdqhtns 112 34 . . . cord-320959-sgdqhtns 113 1 5 5 LS cord-320959-sgdqhtns 114 1 Since since IN cord-320959-sgdqhtns 114 2 the the DT cord-320959-sgdqhtns 114 3 observed observed JJ cord-320959-sgdqhtns 114 4 level level NN cord-320959-sgdqhtns 114 5 of of IN cord-320959-sgdqhtns 114 6 Vitamin vitamin NN cord-320959-sgdqhtns 114 7 E e NN cord-320959-sgdqhtns 114 8 acetate acetate NN cord-320959-sgdqhtns 114 9 in in IN cord-320959-sgdqhtns 114 10 BAL bal NN cord-320959-sgdqhtns 114 11 fluids fluid NNS cord-320959-sgdqhtns 114 12 is be VBZ cord-320959-sgdqhtns 114 13 of of IN cord-320959-sgdqhtns 114 14 same same JJ cord-320959-sgdqhtns 114 15 orders order NNS cord-320959-sgdqhtns 114 16 of of IN cord-320959-sgdqhtns 114 17 magnitude magnitude NN cord-320959-sgdqhtns 114 18 with with IN cord-320959-sgdqhtns 114 19 that that DT cord-320959-sgdqhtns 114 20 of of IN cord-320959-sgdqhtns 114 21 DAG DAG NNP cord-320959-sgdqhtns 114 22 , , , cord-320959-sgdqhtns 114 23 a a DT cord-320959-sgdqhtns 114 24 potent potent JJ cord-320959-sgdqhtns 114 25 second second JJ cord-320959-sgdqhtns 114 26 messenger messenger NN cord-320959-sgdqhtns 114 27 with with IN cord-320959-sgdqhtns 114 28 which which WDT cord-320959-sgdqhtns 114 29 Vitamin vitamin NN cord-320959-sgdqhtns 114 30 E e NN cord-320959-sgdqhtns 114 31 acetate acetate NN cord-320959-sgdqhtns 114 32 competes compete VBZ cord-320959-sgdqhtns 114 33 for for IN cord-320959-sgdqhtns 114 34 binding bind VBG cord-320959-sgdqhtns 114 35 [ [ -LRB- cord-320959-sgdqhtns 114 36 59 59 CD cord-320959-sgdqhtns 114 37 ] ] -RRB- cord-320959-sgdqhtns 114 38 , , , cord-320959-sgdqhtns 114 39 the the DT cord-320959-sgdqhtns 114 40 activity activity NN cord-320959-sgdqhtns 114 41 of of IN cord-320959-sgdqhtns 114 42 the the DT cord-320959-sgdqhtns 114 43 substance substance NN cord-320959-sgdqhtns 114 44 as as IN cord-320959-sgdqhtns 114 45 a a DT cord-320959-sgdqhtns 114 46 modulator modulator NN cord-320959-sgdqhtns 114 47 of of IN cord-320959-sgdqhtns 114 48 DGK DGK NNP cord-320959-sgdqhtns 114 49 - - HYPH cord-320959-sgdqhtns 114 50 PKC PKC NNP cord-320959-sgdqhtns 114 51 pathway pathway NN cord-320959-sgdqhtns 114 52 is be VBZ cord-320959-sgdqhtns 114 53 physiologically physiologically RB cord-320959-sgdqhtns 114 54 relevant relevant JJ cord-320959-sgdqhtns 114 55 . . . cord-320959-sgdqhtns 115 1 However however RB cord-320959-sgdqhtns 115 2 , , , cord-320959-sgdqhtns 115 3 the the DT cord-320959-sgdqhtns 115 4 reported report VBN cord-320959-sgdqhtns 115 5 anti anti JJ cord-320959-sgdqhtns 115 6 - - JJ cord-320959-sgdqhtns 115 7 inflammatory inflammatory JJ cord-320959-sgdqhtns 115 8 effects effect NNS cord-320959-sgdqhtns 115 9 of of IN cord-320959-sgdqhtns 115 10 d d NN cord-320959-sgdqhtns 115 11 - - HYPH cord-320959-sgdqhtns 115 12 α α NN cord-320959-sgdqhtns 115 13 - - HYPH cord-320959-sgdqhtns 115 14 tocopherol tocopherol NN cord-320959-sgdqhtns 115 15 in in IN cord-320959-sgdqhtns 115 16 the the DT cord-320959-sgdqhtns 115 17 pulmonary pulmonary JJ cord-320959-sgdqhtns 115 18 system system NN cord-320959-sgdqhtns 115 19 through through IN cord-320959-sgdqhtns 115 20 post post JJ cord-320959-sgdqhtns 115 21 - - JJ cord-320959-sgdqhtns 115 22 translational translational JJ cord-320959-sgdqhtns 115 23 inactivation inactivation NN cord-320959-sgdqhtns 115 24 of of IN cord-320959-sgdqhtns 115 25 PKCα PKCα NNS cord-320959-sgdqhtns 115 26 significantly significantly RB cord-320959-sgdqhtns 115 27 undermines undermine VBZ cord-320959-sgdqhtns 115 28 this this DT cord-320959-sgdqhtns 115 29 hypothesis hypothesis NN cord-320959-sgdqhtns 115 30 10 10 CD cord-320959-sgdqhtns 115 31 [ [ -LRB- cord-320959-sgdqhtns 115 32 60 60 CD cord-320959-sgdqhtns 115 33 , , , cord-320959-sgdqhtns 115 34 61 61 CD cord-320959-sgdqhtns 115 35 ] ] -RRB- cord-320959-sgdqhtns 115 36 . . . cord-320959-sgdqhtns 116 1 Since since IN cord-320959-sgdqhtns 116 2 many many JJ cord-320959-sgdqhtns 116 3 observations observation NNS cord-320959-sgdqhtns 116 4 suggest suggest VBP cord-320959-sgdqhtns 116 5 that that IN cord-320959-sgdqhtns 116 6 the the DT cord-320959-sgdqhtns 116 7 antagonism antagonism NN cord-320959-sgdqhtns 116 8 of of IN cord-320959-sgdqhtns 116 9 PKCα PKCα NNS cord-320959-sgdqhtns 116 10 by by IN cord-320959-sgdqhtns 116 11 d d NN cord-320959-sgdqhtns 116 12 - - HYPH cord-320959-sgdqhtns 116 13 α α NN cord-320959-sgdqhtns 116 14 - - HYPH cord-320959-sgdqhtns 116 15 tocopherol tocopherol NN cord-320959-sgdqhtns 116 16 is be VBZ cord-320959-sgdqhtns 116 17 independent independent JJ cord-320959-sgdqhtns 116 18 of of IN cord-320959-sgdqhtns 116 19 its -PRON- PRP$ cord-320959-sgdqhtns 116 20 antioxidative antioxidative JJ cord-320959-sgdqhtns 116 21 property property NN cord-320959-sgdqhtns 116 22 [ [ -LRB- cord-320959-sgdqhtns 116 23 57 57 CD cord-320959-sgdqhtns 116 24 ] ] -RRB- cord-320959-sgdqhtns 116 25 , , , cord-320959-sgdqhtns 116 26 it -PRON- PRP cord-320959-sgdqhtns 116 27 is be VBZ cord-320959-sgdqhtns 116 28 anticipated anticipate VBN cord-320959-sgdqhtns 116 29 that that IN cord-320959-sgdqhtns 116 30 Vitamin vitamin NN cord-320959-sgdqhtns 116 31 E e NN cord-320959-sgdqhtns 116 32 acetate acetate NN cord-320959-sgdqhtns 116 33 might may MD cord-320959-sgdqhtns 116 34 play play VB cord-320959-sgdqhtns 116 35 an an DT cord-320959-sgdqhtns 116 36 analogous analogous JJ cord-320959-sgdqhtns 116 37 anti anti JJ cord-320959-sgdqhtns 116 38 - - JJ cord-320959-sgdqhtns 116 39 inflammatory inflammatory JJ cord-320959-sgdqhtns 116 40 role role NN cord-320959-sgdqhtns 116 41 in in IN cord-320959-sgdqhtns 116 42 the the DT cord-320959-sgdqhtns 116 43 pulmonary pulmonary JJ cord-320959-sgdqhtns 116 44 system system NN cord-320959-sgdqhtns 116 45 [ [ -LRB- cord-320959-sgdqhtns 116 46 62 62 CD cord-320959-sgdqhtns 116 47 , , , cord-320959-sgdqhtns 116 48 63 63 CD cord-320959-sgdqhtns 116 49 ] ] -RRB- cord-320959-sgdqhtns 116 50 . . . cord-320959-sgdqhtns 117 1 However however RB cord-320959-sgdqhtns 117 2 , , , cord-320959-sgdqhtns 117 3 whether whether IN cord-320959-sgdqhtns 117 4 the the DT cord-320959-sgdqhtns 117 5 esterified esterified JJ cord-320959-sgdqhtns 117 6 derivative derivative NN cord-320959-sgdqhtns 117 7 antagonizes antagonize VBZ cord-320959-sgdqhtns 117 8 PKCα PKCα NNS cord-320959-sgdqhtns 117 9 still still RB cord-320959-sgdqhtns 117 10 remains remain VBZ cord-320959-sgdqhtns 117 11 to to TO cord-320959-sgdqhtns 117 12 be be VB cord-320959-sgdqhtns 117 13 investigated investigate VBN cord-320959-sgdqhtns 117 14 . . . cord-320959-sgdqhtns 118 1 Overall overall RB cord-320959-sgdqhtns 118 2 , , , cord-320959-sgdqhtns 118 3 the the DT cord-320959-sgdqhtns 118 4 modulation modulation NN cord-320959-sgdqhtns 118 5 of of IN cord-320959-sgdqhtns 118 6 DGK DGK NNP cord-320959-sgdqhtns 118 7 - - HYPH cord-320959-sgdqhtns 118 8 PKC PKC NNP cord-320959-sgdqhtns 118 9 pathway pathway NN cord-320959-sgdqhtns 118 10 by by IN cord-320959-sgdqhtns 119 1 Vitamin vitamin NN cord-320959-sgdqhtns 119 2 E e NN cord-320959-sgdqhtns 119 3 acetate acetate NN cord-320959-sgdqhtns 119 4 seems seem VBZ cord-320959-sgdqhtns 119 5 yet yet RB cord-320959-sgdqhtns 119 6 incapable incapable JJ cord-320959-sgdqhtns 119 7 of of IN cord-320959-sgdqhtns 119 8 accounting account VBG cord-320959-sgdqhtns 119 9 for for IN cord-320959-sgdqhtns 119 10 the the DT cord-320959-sgdqhtns 119 11 15 15 CD cord-320959-sgdqhtns 119 12 observation observation NN cord-320959-sgdqhtns 119 13 of of IN cord-320959-sgdqhtns 119 14 pro pro JJ cord-320959-sgdqhtns 119 15 - - JJ cord-320959-sgdqhtns 119 16 inflammatory inflammatory JJ cord-320959-sgdqhtns 119 17 intraalveolar intraalveolar JJ cord-320959-sgdqhtns 119 18 lipid lipid NN cord-320959-sgdqhtns 119 19 - - HYPH cord-320959-sgdqhtns 119 20 laden laden JJ cord-320959-sgdqhtns 119 21 macrophages macrophage NNS cord-320959-sgdqhtns 119 22 in in IN cord-320959-sgdqhtns 119 23 patients patient NNS cord-320959-sgdqhtns 119 24 with with IN cord-320959-sgdqhtns 119 25 EVALI EVALI NNS cord-320959-sgdqhtns 119 26 , , , cord-320959-sgdqhtns 119 27 although although IN cord-320959-sgdqhtns 119 28 there there EX cord-320959-sgdqhtns 119 29 is be VBZ cord-320959-sgdqhtns 119 30 yet yet RB cord-320959-sgdqhtns 119 31 lacking lack VBG cord-320959-sgdqhtns 119 32 amount amount NN cord-320959-sgdqhtns 119 33 of of IN cord-320959-sgdqhtns 119 34 evidence evidence NN cord-320959-sgdqhtns 119 35 to to TO cord-320959-sgdqhtns 119 36 completely completely RB cord-320959-sgdqhtns 119 37 rule rule VB cord-320959-sgdqhtns 119 38 out out RP cord-320959-sgdqhtns 119 39 this this DT cord-320959-sgdqhtns 119 40 hypothesis hypothesis NN cord-320959-sgdqhtns 119 41 . . . cord-320959-sgdqhtns 120 1 When when WRB cord-320959-sgdqhtns 120 2 Vitamin vitamin NN cord-320959-sgdqhtns 120 3 E e NN cord-320959-sgdqhtns 120 4 is be VBZ cord-320959-sgdqhtns 120 5 administered administer VBN cord-320959-sgdqhtns 120 6 into into IN cord-320959-sgdqhtns 120 7 the the DT cord-320959-sgdqhtns 120 8 biological biological JJ cord-320959-sgdqhtns 120 9 system system NN cord-320959-sgdqhtns 120 10 , , , cord-320959-sgdqhtns 120 11 it -PRON- PRP cord-320959-sgdqhtns 120 12 transforms transform VBZ cord-320959-sgdqhtns 120 13 into into IN cord-320959-sgdqhtns 120 14 a a DT cord-320959-sgdqhtns 120 15 plethora plethora NN cord-320959-sgdqhtns 120 16 of of IN cord-320959-sgdqhtns 120 17 20 20 CD cord-320959-sgdqhtns 120 18 bioactive bioactive JJ cord-320959-sgdqhtns 120 19 metabolites metabolite NNS cord-320959-sgdqhtns 120 20 [ [ -LRB- cord-320959-sgdqhtns 120 21 64 64 CD cord-320959-sgdqhtns 120 22 ] ] -RRB- cord-320959-sgdqhtns 120 23 . . . cord-320959-sgdqhtns 121 1 This this DT cord-320959-sgdqhtns 121 2 includes include VBZ cord-320959-sgdqhtns 121 3 several several JJ cord-320959-sgdqhtns 121 4 of of IN cord-320959-sgdqhtns 121 5 the the DT cord-320959-sgdqhtns 121 6 PXR PXR NNP cord-320959-sgdqhtns 121 7 agonists agonist NNS cord-320959-sgdqhtns 121 8 , , , cord-320959-sgdqhtns 121 9 such such JJ cord-320959-sgdqhtns 121 10 as as IN cord-320959-sgdqhtns 121 11 α α NNP cord-320959-sgdqhtns 121 12 - - : cord-320959-sgdqhtns 121 13 tocopherol-13'-COOH tocopherol-13'-COOH NNP cord-320959-sgdqhtns 121 14 , , , cord-320959-sgdqhtns 121 15 γ γ NN cord-320959-sgdqhtns 121 16 - - HYPH cord-320959-sgdqhtns 121 17 tocotrienol tocotrienol NNP cord-320959-sgdqhtns 121 18 , , , cord-320959-sgdqhtns 121 19 and and CC cord-320959-sgdqhtns 121 20 garcinoic garcinoic NNP cord-320959-sgdqhtns 121 21 acid acid NNP cord-320959-sgdqhtns 121 22 [ [ -LRB- cord-320959-sgdqhtns 122 1 65 65 CD cord-320959-sgdqhtns 122 2 , , , cord-320959-sgdqhtns 122 3 66 66 CD cord-320959-sgdqhtns 122 4 ] ] -RRB- cord-320959-sgdqhtns 122 5 . . . cord-320959-sgdqhtns 123 1 Since since IN cord-320959-sgdqhtns 123 2 PXR PXR NNP cord-320959-sgdqhtns 123 3 forms form VBZ cord-320959-sgdqhtns 123 4 a a DT cord-320959-sgdqhtns 123 5 heterodimer heterodimer NN cord-320959-sgdqhtns 123 6 with with IN cord-320959-sgdqhtns 123 7 9cis 9cis CD cord-320959-sgdqhtns 123 8 retinoic retinoic JJ cord-320959-sgdqhtns 123 9 acid acid NN cord-320959-sgdqhtns 123 10 receptor receptor NN cord-320959-sgdqhtns 123 11 ( ( -LRB- cord-320959-sgdqhtns 123 12 NR2B nr2b NN cord-320959-sgdqhtns 123 13 ) ) -RRB- cord-320959-sgdqhtns 123 14 to to TO cord-320959-sgdqhtns 123 15 activate activate VB cord-320959-sgdqhtns 123 16 the the DT cord-320959-sgdqhtns 123 17 transcription transcription NN cord-320959-sgdqhtns 123 18 of of IN cord-320959-sgdqhtns 123 19 cytochrome cytochrome NN cord-320959-sgdqhtns 123 20 P450 p450 JJ cord-320959-sgdqhtns 123 21 monooxygenase monooxygenase NN cord-320959-sgdqhtns 123 22 genes gene NNS cord-320959-sgdqhtns 123 23 indicated indicate VBN cord-320959-sgdqhtns 123 24 in in IN cord-320959-sgdqhtns 123 25 the the DT cord-320959-sgdqhtns 123 26 clearance clearance NN cord-320959-sgdqhtns 123 27 and and CC cord-320959-sgdqhtns 123 28 detoxification detoxification NN cord-320959-sgdqhtns 123 29 of of IN cord-320959-sgdqhtns 123 30 xenobiotic xenobiotic JJ cord-320959-sgdqhtns 123 31 substances substance NNS cord-320959-sgdqhtns 123 32 13 13 CD cord-320959-sgdqhtns 123 33 [ [ -LRB- cord-320959-sgdqhtns 123 34 67 67 CD cord-320959-sgdqhtns 123 35 ] ] -RRB- cord-320959-sgdqhtns 123 36 , , , cord-320959-sgdqhtns 123 37 pro pro JJ cord-320959-sgdqhtns 123 38 - - JJ cord-320959-sgdqhtns 123 39 agonist agonist JJ cord-320959-sgdqhtns 123 40 role role NN cord-320959-sgdqhtns 123 41 of of IN cord-320959-sgdqhtns 123 42 Vitamin vitamin NN cord-320959-sgdqhtns 123 43 E e NN cord-320959-sgdqhtns 123 44 acetate acetate NN cord-320959-sgdqhtns 123 45 may may MD cord-320959-sgdqhtns 123 46 be be VB cord-320959-sgdqhtns 123 47 relevant relevant JJ cord-320959-sgdqhtns 123 48 in in IN cord-320959-sgdqhtns 123 49 the the DT cord-320959-sgdqhtns 123 50 pathophysiology pathophysiology NN cord-320959-sgdqhtns 123 51 of of IN cord-320959-sgdqhtns 123 52 EVALI EVALI NNS cord-320959-sgdqhtns 123 53 . . . cord-320959-sgdqhtns 124 1 Indeed indeed RB cord-320959-sgdqhtns 124 2 , , , cord-320959-sgdqhtns 124 3 polymorphisms polymorphism NNS cord-320959-sgdqhtns 124 4 in in IN cord-320959-sgdqhtns 124 5 the the DT cord-320959-sgdqhtns 124 6 cytochrome cytochrome NN cord-320959-sgdqhtns 124 7 P450 p450 JJ cord-320959-sgdqhtns 124 8 genes gene NNS cord-320959-sgdqhtns 124 9 have have VBP cord-320959-sgdqhtns 124 10 been be VBN cord-320959-sgdqhtns 124 11 associated associate VBN cord-320959-sgdqhtns 124 12 with with IN cord-320959-sgdqhtns 124 13 drug drug NN cord-320959-sgdqhtns 124 14 - - HYPH cord-320959-sgdqhtns 124 15 induced induce VBN cord-320959-sgdqhtns 124 16 interstitial interstitial JJ cord-320959-sgdqhtns 124 17 lung lung NN cord-320959-sgdqhtns 124 18 diseases disease NNS cord-320959-sgdqhtns 124 19 ( ( -LRB- cord-320959-sgdqhtns 124 20 DIILD DIILD NNP cord-320959-sgdqhtns 124 21 ) ) -RRB- cord-320959-sgdqhtns 124 22 , , , cord-320959-sgdqhtns 124 23 characterized characterize VBN cord-320959-sgdqhtns 124 24 by by IN cord-320959-sgdqhtns 124 25 coarse coarse JJ cord-320959-sgdqhtns 124 26 reticular reticular JJ cord-320959-sgdqhtns 124 27 opacity opacity NN cord-320959-sgdqhtns 124 28 and and CC cord-320959-sgdqhtns 124 29 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 124 30 lipid lipid NN cord-320959-sgdqhtns 124 31 - - HYPH cord-320959-sgdqhtns 124 32 laden laden NN cord-320959-sgdqhtns 124 33 macrophages macrophage NNS cord-320959-sgdqhtns 124 34 [ [ -LRB- cord-320959-sgdqhtns 124 35 68 68 CD cord-320959-sgdqhtns 124 36 ] ] -RRB- cord-320959-sgdqhtns 124 37 . . . cord-320959-sgdqhtns 125 1 This this DT cord-320959-sgdqhtns 125 2 pathology pathology NN cord-320959-sgdqhtns 125 3 is be VBZ cord-320959-sgdqhtns 125 4 consistent consistent JJ cord-320959-sgdqhtns 125 5 with with IN cord-320959-sgdqhtns 125 6 that that DT cord-320959-sgdqhtns 125 7 of of IN cord-320959-sgdqhtns 125 8 EVALI EVALI NNP cord-320959-sgdqhtns 125 9 , , , cord-320959-sgdqhtns 125 10 wherein wherein WRB cord-320959-sgdqhtns 125 11 patients patient NNS cord-320959-sgdqhtns 125 12 5 5 CD cord-320959-sgdqhtns 125 13 often often RB cord-320959-sgdqhtns 125 14 reported report VBD cord-320959-sgdqhtns 125 15 patterns pattern NNS cord-320959-sgdqhtns 125 16 of of IN cord-320959-sgdqhtns 125 17 giant giant JJ cord-320959-sgdqhtns 125 18 - - HYPH cord-320959-sgdqhtns 125 19 cell cell NN cord-320959-sgdqhtns 125 20 interstitial interstitial JJ cord-320959-sgdqhtns 125 21 pneumonia pneumonia NN cord-320959-sgdqhtns 125 22 [ [ -LRB- cord-320959-sgdqhtns 125 23 4 4 CD cord-320959-sgdqhtns 125 24 ] ] -RRB- cord-320959-sgdqhtns 125 25 . . . cord-320959-sgdqhtns 126 1 In in IN cord-320959-sgdqhtns 126 2 this this DT cord-320959-sgdqhtns 126 3 picture picture NN cord-320959-sgdqhtns 126 4 , , , cord-320959-sgdqhtns 126 5 EVALI EVALI NNP cord-320959-sgdqhtns 126 6 can can MD cord-320959-sgdqhtns 126 7 be be VB cord-320959-sgdqhtns 126 8 seen see VBN cord-320959-sgdqhtns 126 9 as as IN cord-320959-sgdqhtns 126 10 a a DT cord-320959-sgdqhtns 126 11 variant variant NN cord-320959-sgdqhtns 126 12 of of IN cord-320959-sgdqhtns 126 13 DIILD DIILD NNS cord-320959-sgdqhtns 126 14 caused cause VBN cord-320959-sgdqhtns 126 15 by by IN cord-320959-sgdqhtns 126 16 an an DT cord-320959-sgdqhtns 126 17 excessive excessive JJ cord-320959-sgdqhtns 126 18 accumulation accumulation NN cord-320959-sgdqhtns 126 19 of of IN cord-320959-sgdqhtns 126 20 Vitamin vitamin NN cord-320959-sgdqhtns 126 21 E e NN cord-320959-sgdqhtns 126 22 acetate acetate NN cord-320959-sgdqhtns 126 23 in in IN cord-320959-sgdqhtns 126 24 the the DT cord-320959-sgdqhtns 126 25 pulmonary pulmonary JJ cord-320959-sgdqhtns 126 26 system system NN cord-320959-sgdqhtns 126 27 . . . cord-320959-sgdqhtns 127 1 Despite despite IN cord-320959-sgdqhtns 127 2 its -PRON- PRP$ cord-320959-sgdqhtns 127 3 pathophysiology pathophysiology NN cord-320959-sgdqhtns 127 4 being be VBG cord-320959-sgdqhtns 127 5 not not RB cord-320959-sgdqhtns 127 6 fully fully RB cord-320959-sgdqhtns 127 7 characterized characterize VBN cord-320959-sgdqhtns 127 8 , , , cord-320959-sgdqhtns 127 9 DIILD DIILD NNP cord-320959-sgdqhtns 127 10 often often RB cord-320959-sgdqhtns 127 11 involves involve VBZ cord-320959-sgdqhtns 127 12 the the DT cord-320959-sgdqhtns 127 13 generation generation NN cord-320959-sgdqhtns 127 14 of of IN cord-320959-sgdqhtns 127 15 reactive reactive JJ cord-320959-sgdqhtns 127 16 oxygen oxygen NN cord-320959-sgdqhtns 127 17 species specie NNS cord-320959-sgdqhtns 127 18 [ [ -LRB- cord-320959-sgdqhtns 127 19 69 69 CD cord-320959-sgdqhtns 127 20 , , , cord-320959-sgdqhtns 127 21 70 70 CD cord-320959-sgdqhtns 127 22 ] ] -RRB- cord-320959-sgdqhtns 127 23 . . . cord-320959-sgdqhtns 128 1 Vitamin vitamin NN cord-320959-sgdqhtns 128 2 E e NN cord-320959-sgdqhtns 128 3 acetate acetate NN cord-320959-sgdqhtns 128 4 , , , cord-320959-sgdqhtns 128 5 however however RB cord-320959-sgdqhtns 128 6 , , , cord-320959-sgdqhtns 128 7 is be VBZ cord-320959-sgdqhtns 128 8 known know VBN cord-320959-sgdqhtns 128 9 to to TO cord-320959-sgdqhtns 128 10 protect protect VB cord-320959-sgdqhtns 128 11 the the DT cord-320959-sgdqhtns 128 12 biological biological JJ cord-320959-sgdqhtns 128 13 system system NN cord-320959-sgdqhtns 128 14 against against IN cord-320959-sgdqhtns 128 15 reactive reactive JJ cord-320959-sgdqhtns 128 16 oxygen oxygen NN cord-320959-sgdqhtns 128 17 species specie NNS cord-320959-sgdqhtns 128 18 even even RB cord-320959-sgdqhtns 128 19 in in IN cord-320959-sgdqhtns 128 20 the the DT cord-320959-sgdqhtns 128 21 absence absence NN cord-320959-sgdqhtns 128 22 of of IN cord-320959-sgdqhtns 128 23 10 10 CD cord-320959-sgdqhtns 128 24 apparent apparent JJ cord-320959-sgdqhtns 128 25 hydrolysis hydrolysis NN cord-320959-sgdqhtns 128 26 [ [ -LRB- cord-320959-sgdqhtns 128 27 24 24 CD cord-320959-sgdqhtns 128 28 ] ] -RRB- cord-320959-sgdqhtns 128 29 , , , cord-320959-sgdqhtns 128 30 possibly possibly RB cord-320959-sgdqhtns 128 31 through through IN cord-320959-sgdqhtns 128 32 its -PRON- PRP$ cord-320959-sgdqhtns 128 33 inhibition inhibition NN cord-320959-sgdqhtns 128 34 of of IN cord-320959-sgdqhtns 128 35 5-LO 5-lo CD cord-320959-sgdqhtns 128 36 [ [ -LRB- cord-320959-sgdqhtns 128 37 15 15 CD cord-320959-sgdqhtns 128 38 ] ] -RRB- cord-320959-sgdqhtns 128 39 or or CC cord-320959-sgdqhtns 128 40 through through IN cord-320959-sgdqhtns 128 41 infinitesimal infinitesimal JJ cord-320959-sgdqhtns 128 42 hydrolysis hydrolysis NN cord-320959-sgdqhtns 128 43 to to IN cord-320959-sgdqhtns 128 44 Vitamin vitamin NN cord-320959-sgdqhtns 128 45 E e NN cord-320959-sgdqhtns 128 46 as as RB cord-320959-sgdqhtns 128 47 previously previously RB cord-320959-sgdqhtns 128 48 speculated speculate VBN cord-320959-sgdqhtns 128 49 [ [ -LRB- cord-320959-sgdqhtns 128 50 24 24 CD cord-320959-sgdqhtns 128 51 ] ] -RRB- cord-320959-sgdqhtns 128 52 . . . cord-320959-sgdqhtns 129 1 Furthermore furthermore RB cord-320959-sgdqhtns 129 2 , , , cord-320959-sgdqhtns 129 3 DIILD DIILD NNP cord-320959-sgdqhtns 129 4 is be VBZ cord-320959-sgdqhtns 129 5 a a DT cord-320959-sgdqhtns 129 6 highly highly RB cord-320959-sgdqhtns 129 7 heterogenous heterogenous JJ cord-320959-sgdqhtns 129 8 disorder disorder NN cord-320959-sgdqhtns 129 9 , , , cord-320959-sgdqhtns 129 10 that that WDT cord-320959-sgdqhtns 129 11 is be VBZ cord-320959-sgdqhtns 129 12 often often RB cord-320959-sgdqhtns 129 13 dependent dependent JJ cord-320959-sgdqhtns 129 14 on on IN cord-320959-sgdqhtns 129 15 genetic genetic JJ cord-320959-sgdqhtns 129 16 polymorphisms polymorphism NNS cord-320959-sgdqhtns 129 17 rare rare JJ cord-320959-sgdqhtns 129 18 enough enough RB cord-320959-sgdqhtns 129 19 to to TO cord-320959-sgdqhtns 129 20 avert avert VB cord-320959-sgdqhtns 129 21 federal federal JJ cord-320959-sgdqhtns 129 22 regulations regulation NNS cord-320959-sgdqhtns 129 23 during during IN cord-320959-sgdqhtns 129 24 drug drug NN cord-320959-sgdqhtns 129 25 approval approval NN cord-320959-sgdqhtns 129 26 [ [ -LRB- cord-320959-sgdqhtns 129 27 71 71 CD cord-320959-sgdqhtns 129 28 , , , cord-320959-sgdqhtns 129 29 72 72 CD cord-320959-sgdqhtns 129 30 ] ] -RRB- cord-320959-sgdqhtns 129 31 . . . cord-320959-sgdqhtns 130 1 For for IN cord-320959-sgdqhtns 130 2 instance instance NN cord-320959-sgdqhtns 130 3 , , , cord-320959-sgdqhtns 130 4 the the DT cord-320959-sgdqhtns 130 5 demonstration demonstration NN cord-320959-sgdqhtns 130 6 of of IN cord-320959-sgdqhtns 130 7 respiratory respiratory JJ cord-320959-sgdqhtns 130 8 symptom symptom NN cord-320959-sgdqhtns 130 9 after after IN cord-320959-sgdqhtns 130 10 oral oral JJ cord-320959-sgdqhtns 130 11 administration administration NNP cord-320959-sgdqhtns 130 12 of of IN cord-320959-sgdqhtns 130 13 fenfluramine fenfluramine NNP cord-320959-sgdqhtns 130 14 or or CC cord-320959-sgdqhtns 130 15 dexfenfluramine dexfenfluramine NNP cord-320959-sgdqhtns 130 16 was be VBD cord-320959-sgdqhtns 130 17 on on IN cord-320959-sgdqhtns 130 18 a a DT cord-320959-sgdqhtns 130 19 patient patient NN cord-320959-sgdqhtns 130 20 with with IN cord-320959-sgdqhtns 130 21 a a DT cord-320959-sgdqhtns 130 22 15 15 CD cord-320959-sgdqhtns 130 23 rare rare JJ cord-320959-sgdqhtns 130 24 CYP2D6 CYP2D6 NNPS cord-320959-sgdqhtns 130 25 * * NFP cord-320959-sgdqhtns 130 26 1/*3 1/*3 CD cord-320959-sgdqhtns 130 27 haplodeficient haplodeficient NN cord-320959-sgdqhtns 130 28 variant variant NN cord-320959-sgdqhtns 130 29 of of IN cord-320959-sgdqhtns 130 30 the the DT cord-320959-sgdqhtns 130 31 cytochrome cytochrome NN cord-320959-sgdqhtns 130 32 P450 p450 NN cord-320959-sgdqhtns 130 33 2D6 2d6 CD cord-320959-sgdqhtns 130 34 ( ( -LRB- cord-320959-sgdqhtns 130 35 CYP2D6 CYP2D6 NNP cord-320959-sgdqhtns 130 36 ) ) -RRB- cord-320959-sgdqhtns 130 37 gene gene NN cord-320959-sgdqhtns 130 38 [ [ -LRB- cord-320959-sgdqhtns 130 39 68 68 CD cord-320959-sgdqhtns 130 40 ] ] -RRB- cord-320959-sgdqhtns 130 41 . . . cord-320959-sgdqhtns 131 1 How how WRB cord-320959-sgdqhtns 131 2 haplodeficiency haplodeficiency NN cord-320959-sgdqhtns 131 3 of of IN cord-320959-sgdqhtns 131 4 the the DT cord-320959-sgdqhtns 131 5 CYP2D6 cyp2d6 JJ cord-320959-sgdqhtns 131 6 gene gene NN cord-320959-sgdqhtns 131 7 contributes contribute VBZ cord-320959-sgdqhtns 131 8 to to IN cord-320959-sgdqhtns 131 9 the the DT cord-320959-sgdqhtns 131 10 pathogenesis pathogenesis NN cord-320959-sgdqhtns 131 11 of of IN cord-320959-sgdqhtns 131 12 DIILD DIILD NNP cord-320959-sgdqhtns 131 13 remains remain VBZ cord-320959-sgdqhtns 131 14 unclear unclear JJ cord-320959-sgdqhtns 131 15 . . . cord-320959-sgdqhtns 132 1 If if IN cord-320959-sgdqhtns 132 2 Vitamin vitamin NN cord-320959-sgdqhtns 132 3 E e NN cord-320959-sgdqhtns 132 4 acetate acetate NN cord-320959-sgdqhtns 132 5 behaves behave VBZ cord-320959-sgdqhtns 132 6 as as IN cord-320959-sgdqhtns 132 7 a a DT cord-320959-sgdqhtns 132 8 pro pro JJ cord-320959-sgdqhtns 132 9 - - JJ cord-320959-sgdqhtns 132 10 agonist agonist JJ cord-320959-sgdqhtns 132 11 of of IN cord-320959-sgdqhtns 132 12 PXR PXR NNP cord-320959-sgdqhtns 132 13 , , , cord-320959-sgdqhtns 132 14 a a DT cord-320959-sgdqhtns 132 15 transcriptional transcriptional JJ cord-320959-sgdqhtns 132 16 activator activator NN cord-320959-sgdqhtns 132 17 of of IN cord-320959-sgdqhtns 132 18 cytochrome cytochrome NN cord-320959-sgdqhtns 132 19 P450 p450 JJ cord-320959-sgdqhtns 132 20 genes gene NNS cord-320959-sgdqhtns 132 21 , , , cord-320959-sgdqhtns 132 22 and and CC cord-320959-sgdqhtns 132 23 thereby thereby RB cord-320959-sgdqhtns 132 24 contributes contribute VBZ cord-320959-sgdqhtns 132 25 to to IN cord-320959-sgdqhtns 132 26 the the DT cord-320959-sgdqhtns 132 27 pathogenesis pathogenesis NN cord-320959-sgdqhtns 132 28 of of IN cord-320959-sgdqhtns 132 29 EVALI EVALI NNS cord-320959-sgdqhtns 132 30 , , , cord-320959-sgdqhtns 132 31 the the DT cord-320959-sgdqhtns 132 32 symptoms symptom NNS cord-320959-sgdqhtns 132 33 of of IN cord-320959-sgdqhtns 132 34 EVALI evali NN cord-320959-sgdqhtns 132 35 20 20 CD cord-320959-sgdqhtns 132 36 should should MD cord-320959-sgdqhtns 132 37 be be VB cord-320959-sgdqhtns 132 38 replicated replicate VBN cord-320959-sgdqhtns 132 39 by by IN cord-320959-sgdqhtns 132 40 inhalation inhalation NN cord-320959-sgdqhtns 132 41 of of IN cord-320959-sgdqhtns 132 42 other other JJ cord-320959-sgdqhtns 132 43 well well RB cord-320959-sgdqhtns 132 44 - - HYPH cord-320959-sgdqhtns 132 45 established establish VBN cord-320959-sgdqhtns 132 46 PXR PXR NNP cord-320959-sgdqhtns 132 47 agonists agonist NNS cord-320959-sgdqhtns 132 48 , , , cord-320959-sgdqhtns 132 49 such such JJ cord-320959-sgdqhtns 132 50 as as IN cord-320959-sgdqhtns 132 51 corticosteroids corticosteroid NNS cord-320959-sgdqhtns 132 52 [ [ -LRB- cord-320959-sgdqhtns 132 53 73 73 CD cord-320959-sgdqhtns 132 54 ] ] -RRB- cord-320959-sgdqhtns 132 55 [ [ -LRB- cord-320959-sgdqhtns 132 56 74 74 CD cord-320959-sgdqhtns 132 57 ] ] -RRB- cord-320959-sgdqhtns 132 58 [ [ -LRB- cord-320959-sgdqhtns 132 59 75 75 CD cord-320959-sgdqhtns 132 60 ] ] -RRB- cord-320959-sgdqhtns 132 61 . . . cord-320959-sgdqhtns 133 1 Nebulized Nebulized NNP cord-320959-sgdqhtns 133 2 budesonide budesonide NNP cord-320959-sgdqhtns 133 3 or or CC cord-320959-sgdqhtns 133 4 fluticasone fluticasone NN cord-320959-sgdqhtns 133 5 , , , cord-320959-sgdqhtns 133 6 however however RB cord-320959-sgdqhtns 133 7 , , , cord-320959-sgdqhtns 133 8 did do VBD cord-320959-sgdqhtns 133 9 not not RB cord-320959-sgdqhtns 133 10 induce induce VB cord-320959-sgdqhtns 133 11 respiratory respiratory JJ cord-320959-sgdqhtns 133 12 distress distress NN cord-320959-sgdqhtns 133 13 when when WRB cord-320959-sgdqhtns 133 14 inhaled inhale VBN cord-320959-sgdqhtns 133 15 repeatedly repeatedly RB cord-320959-sgdqhtns 133 16 ( ( -LRB- cord-320959-sgdqhtns 133 17 inhalation inhalation NN cord-320959-sgdqhtns 133 18 of of IN cord-320959-sgdqhtns 133 19 125 125 CD cord-320959-sgdqhtns 133 20 - - SYM cord-320959-sgdqhtns 133 21 200 200 CD cord-320959-sgdqhtns 133 22 μg μg NNP cord-320959-sgdqhtns 133 23 corticosteroids corticosteroid NNS cord-320959-sgdqhtns 133 24 each each DT cord-320959-sgdqhtns 133 25 session session NN cord-320959-sgdqhtns 133 26 , , , cord-320959-sgdqhtns 133 27 2 2 CD cord-320959-sgdqhtns 133 28 - - SYM cord-320959-sgdqhtns 133 29 4 4 CD cord-320959-sgdqhtns 133 30 times time NNS cord-320959-sgdqhtns 133 31 daily daily JJ cord-320959-sgdqhtns 133 32 , , , cord-320959-sgdqhtns 133 33 8 8 CD cord-320959-sgdqhtns 133 34 days day NNS cord-320959-sgdqhtns 133 35 ) ) -RRB- cord-320959-sgdqhtns 133 36 in in IN cord-320959-sgdqhtns 133 37 young young JJ cord-320959-sgdqhtns 133 38 children child NNS cord-320959-sgdqhtns 133 39 with with IN cord-320959-sgdqhtns 133 40 a a DT cord-320959-sgdqhtns 133 41 severe severe JJ cord-320959-sgdqhtns 133 42 onset onset NN cord-320959-sgdqhtns 133 43 of of IN cord-320959-sgdqhtns 133 44 asthma asthma NN cord-320959-sgdqhtns 133 45 [ [ -LRB- cord-320959-sgdqhtns 133 46 76 76 CD cord-320959-sgdqhtns 133 47 ] ] -RRB- cord-320959-sgdqhtns 133 48 . . . cord-320959-sgdqhtns 134 1 Furthermore furthermore RB cord-320959-sgdqhtns 134 2 , , , cord-320959-sgdqhtns 134 3 even even RB cord-320959-sgdqhtns 134 4 in in IN cord-320959-sgdqhtns 134 5 the the DT cord-320959-sgdqhtns 134 6 absence absence NN cord-320959-sgdqhtns 134 7 of of IN cord-320959-sgdqhtns 134 8 14 14 CD cord-320959-sgdqhtns 134 9 Vitamin vitamin NN cord-320959-sgdqhtns 134 10 E e NN cord-320959-sgdqhtns 134 11 acetate acetate NN cord-320959-sgdqhtns 134 12 , , , cord-320959-sgdqhtns 134 13 vaping vape VBG cord-320959-sgdqhtns 134 14 induced induce VBN cord-320959-sgdqhtns 134 15 significant significant JJ cord-320959-sgdqhtns 134 16 increase increase NN cord-320959-sgdqhtns 134 17 in in IN cord-320959-sgdqhtns 134 18 the the DT cord-320959-sgdqhtns 134 19 activity activity NN cord-320959-sgdqhtns 134 20 of of IN cord-320959-sgdqhtns 134 21 cytochrome cytochrome NN cord-320959-sgdqhtns 134 22 P450 p450 JJ cord-320959-sgdqhtns 134 23 enzymes enzyme NNS cord-320959-sgdqhtns 134 24 , , , cord-320959-sgdqhtns 134 25 including include VBG cord-320959-sgdqhtns 134 26 those those DT cord-320959-sgdqhtns 134 27 hydroxylates hydroxylate NNS cord-320959-sgdqhtns 134 28 Vitamin vitamin NN cord-320959-sgdqhtns 134 29 E E NNP cord-320959-sgdqhtns 134 30 , , , cord-320959-sgdqhtns 134 31 such such JJ cord-320959-sgdqhtns 134 32 as as IN cord-320959-sgdqhtns 134 33 CYP2B1 CYP2B1 NNP cord-320959-sgdqhtns 134 34 , , , cord-320959-sgdqhtns 134 35 CYP2C11 CYP2C11 NNP cord-320959-sgdqhtns 134 36 , , , cord-320959-sgdqhtns 134 37 and and CC cord-320959-sgdqhtns 134 38 CYP3A1 CYP3A1 NNP cord-320959-sgdqhtns 134 39 , , , cord-320959-sgdqhtns 134 40 but but CC cord-320959-sgdqhtns 134 41 without without IN cord-320959-sgdqhtns 134 42 apparent apparent JJ cord-320959-sgdqhtns 134 43 respiratory respiratory JJ cord-320959-sgdqhtns 134 44 distress distress NN cord-320959-sgdqhtns 134 45 [ [ -LRB- cord-320959-sgdqhtns 134 46 77 77 CD cord-320959-sgdqhtns 134 47 ] ] -RRB- cord-320959-sgdqhtns 134 48 . . . cord-320959-sgdqhtns 135 1 However however RB cord-320959-sgdqhtns 135 2 , , , cord-320959-sgdqhtns 135 3 it -PRON- PRP cord-320959-sgdqhtns 135 4 remains remain VBZ cord-320959-sgdqhtns 135 5 to to TO cord-320959-sgdqhtns 135 6 be be VB cord-320959-sgdqhtns 135 7 studied study VBN cord-320959-sgdqhtns 135 8 whether whether IN cord-320959-sgdqhtns 135 9 an an DT cord-320959-sgdqhtns 135 10 excessive excessive JJ cord-320959-sgdqhtns 135 11 accumulation accumulation NN cord-320959-sgdqhtns 135 12 of of IN cord-320959-sgdqhtns 135 13 Vitamin vitamin NN cord-320959-sgdqhtns 135 14 E e NN cord-320959-sgdqhtns 135 15 acetate acetate NN cord-320959-sgdqhtns 135 16 produces produce VBZ cord-320959-sgdqhtns 135 17 PXR pxr NN cord-320959-sgdqhtns 135 18 - - HYPH cord-320959-sgdqhtns 135 19 agonizing agonize VBG cord-320959-sgdqhtns 135 20 metabolites metabolite NNS cord-320959-sgdqhtns 135 21 above above IN cord-320959-sgdqhtns 135 22 a a DT cord-320959-sgdqhtns 135 23 5 5 CD cord-320959-sgdqhtns 135 24 certain certain JJ cord-320959-sgdqhtns 135 25 threshold threshold NN cord-320959-sgdqhtns 135 26 such such JJ cord-320959-sgdqhtns 135 27 that that IN cord-320959-sgdqhtns 135 28 it -PRON- PRP cord-320959-sgdqhtns 135 29 may may MD cord-320959-sgdqhtns 135 30 induce induce VB cord-320959-sgdqhtns 135 31 an an DT cord-320959-sgdqhtns 135 32 acute acute JJ cord-320959-sgdqhtns 135 33 respiratory respiratory JJ cord-320959-sgdqhtns 135 34 distress distress NN cord-320959-sgdqhtns 135 35 . . . cord-320959-sgdqhtns 136 1 Overall overall RB cord-320959-sgdqhtns 136 2 , , , cord-320959-sgdqhtns 136 3 the the DT cord-320959-sgdqhtns 136 4 pro pro JJ cord-320959-sgdqhtns 136 5 - - JJ cord-320959-sgdqhtns 136 6 agonist agonist JJ cord-320959-sgdqhtns 136 7 role role NN cord-320959-sgdqhtns 136 8 of of IN cord-320959-sgdqhtns 136 9 Vitamin vitamin NN cord-320959-sgdqhtns 136 10 E e NN cord-320959-sgdqhtns 136 11 acetate acetate NN cord-320959-sgdqhtns 136 12 on on IN cord-320959-sgdqhtns 136 13 PXR PXR NNP cord-320959-sgdqhtns 136 14 seems seem VBZ cord-320959-sgdqhtns 136 15 relevant relevant JJ cord-320959-sgdqhtns 136 16 in in IN cord-320959-sgdqhtns 136 17 the the DT cord-320959-sgdqhtns 136 18 pathophysiology pathophysiology NN cord-320959-sgdqhtns 136 19 of of IN cord-320959-sgdqhtns 136 20 EVALI EVALI NNS cord-320959-sgdqhtns 136 21 , , , cord-320959-sgdqhtns 136 22 but but CC cord-320959-sgdqhtns 136 23 there there EX cord-320959-sgdqhtns 136 24 is be VBZ cord-320959-sgdqhtns 136 25 yet yet RB cord-320959-sgdqhtns 136 26 lacking lack VBG cord-320959-sgdqhtns 136 27 amount amount NN cord-320959-sgdqhtns 136 28 of of IN cord-320959-sgdqhtns 136 29 evidence evidence NN cord-320959-sgdqhtns 136 30 which which WDT cord-320959-sgdqhtns 136 31 indicates indicate VBZ cord-320959-sgdqhtns 136 32 that that IN cord-320959-sgdqhtns 136 33 the the DT cord-320959-sgdqhtns 136 34 PXR PXR NNP cord-320959-sgdqhtns 136 35 agonism agonism NN cord-320959-sgdqhtns 136 36 drives drive VBZ cord-320959-sgdqhtns 136 37 the the DT cord-320959-sgdqhtns 136 38 pathogenesis pathogenesis NN cord-320959-sgdqhtns 136 39 of of IN cord-320959-sgdqhtns 136 40 EVALI EVALI NNS cord-320959-sgdqhtns 136 41 . . . cord-320959-sgdqhtns 137 1 10 10 CD cord-320959-sgdqhtns 137 2 _SP cord-320959-sgdqhtns 138 1 Recent recent JJ cord-320959-sgdqhtns 138 2 developments development NNS cord-320959-sgdqhtns 138 3 in in IN cord-320959-sgdqhtns 138 4 membrane membrane NN cord-320959-sgdqhtns 138 5 biophysics biophysic NNS cord-320959-sgdqhtns 138 6 indicate indicate VBP cord-320959-sgdqhtns 138 7 that that IN cord-320959-sgdqhtns 138 8 an an DT cord-320959-sgdqhtns 138 9 unmodified unmodified JJ cord-320959-sgdqhtns 138 10 Vitamin vitamin NN cord-320959-sgdqhtns 138 11 E e NN cord-320959-sgdqhtns 138 12 has have VBZ cord-320959-sgdqhtns 138 13 an an DT cord-320959-sgdqhtns 138 14 active active JJ cord-320959-sgdqhtns 138 15 role role NN cord-320959-sgdqhtns 138 16 in in IN cord-320959-sgdqhtns 138 17 lateral lateral JJ cord-320959-sgdqhtns 138 18 phase phase NN cord-320959-sgdqhtns 138 19 separation separation NN cord-320959-sgdqhtns 138 20 . . . cord-320959-sgdqhtns 139 1 Due due IN cord-320959-sgdqhtns 139 2 to to IN cord-320959-sgdqhtns 139 3 the the DT cord-320959-sgdqhtns 139 4 rigid rigid JJ cord-320959-sgdqhtns 139 5 chromane chromane NN cord-320959-sgdqhtns 139 6 double double JJ cord-320959-sgdqhtns 139 7 ring ring NN cord-320959-sgdqhtns 139 8 , , , cord-320959-sgdqhtns 139 9 which which WDT cord-320959-sgdqhtns 139 10 significantly significantly RB cord-320959-sgdqhtns 139 11 reduces reduce VBZ cord-320959-sgdqhtns 139 12 the the DT cord-320959-sgdqhtns 139 13 entropic entropic JJ cord-320959-sgdqhtns 139 14 cost cost NN cord-320959-sgdqhtns 139 15 required require VBN cord-320959-sgdqhtns 139 16 for for IN cord-320959-sgdqhtns 139 17 its -PRON- PRP$ cord-320959-sgdqhtns 139 18 association association NN cord-320959-sgdqhtns 139 19 with with IN cord-320959-sgdqhtns 139 20 cholesterol cholesterol NN cord-320959-sgdqhtns 139 21 [ [ -LRB- cord-320959-sgdqhtns 139 22 78 78 CD cord-320959-sgdqhtns 139 23 ] ] -RRB- cord-320959-sgdqhtns 139 24 , , , cord-320959-sgdqhtns 139 25 unmodified unmodified JJ cord-320959-sgdqhtns 139 26 Vitamin vitamin NN cord-320959-sgdqhtns 139 27 E e NN cord-320959-sgdqhtns 139 28 efficiently efficiently RB cord-320959-sgdqhtns 139 29 releases release VBZ cord-320959-sgdqhtns 139 30 the the DT cord-320959-sgdqhtns 139 31 line line NN cord-320959-sgdqhtns 139 32 tension tension NN cord-320959-sgdqhtns 139 33 ( ( -LRB- cord-320959-sgdqhtns 139 34 i.e. i.e. FW cord-320959-sgdqhtns 139 35 two two CD cord-320959-sgdqhtns 139 36 - - HYPH cord-320959-sgdqhtns 139 37 dimensional dimensional JJ cord-320959-sgdqhtns 139 38 counterpart counterpart NN cord-320959-sgdqhtns 139 39 of of IN cord-320959-sgdqhtns 139 40 a a DT cord-320959-sgdqhtns 139 41 surface surface NN cord-320959-sgdqhtns 139 42 tension tension NN cord-320959-sgdqhtns 139 43 ) ) -RRB- cord-320959-sgdqhtns 139 44 15 15 CD cord-320959-sgdqhtns 139 45 between between IN cord-320959-sgdqhtns 139 46 the the DT cord-320959-sgdqhtns 139 47 liquid liquid NN cord-320959-sgdqhtns 139 48 - - HYPH cord-320959-sgdqhtns 139 49 disordered disordered JJ cord-320959-sgdqhtns 139 50 L l NN cord-320959-sgdqhtns 139 51 α α NN cord-320959-sgdqhtns 139 52 and and CC cord-320959-sgdqhtns 139 53 the the DT cord-320959-sgdqhtns 139 54 liquid liquid NN cord-320959-sgdqhtns 139 55 - - HYPH cord-320959-sgdqhtns 139 56 ordered order VBN cord-320959-sgdqhtns 139 57 L l NN cord-320959-sgdqhtns 139 58 o o NN cord-320959-sgdqhtns 139 59 phase phase NN cord-320959-sgdqhtns 139 60 of of IN cord-320959-sgdqhtns 139 61 lipid lipid NN cord-320959-sgdqhtns 139 62 polymorphs polymorph NNS cord-320959-sgdqhtns 139 63 [ [ -LRB- cord-320959-sgdqhtns 139 64 79 79 CD cord-320959-sgdqhtns 139 65 ] ] -RRB- cord-320959-sgdqhtns 139 66 . . . cord-320959-sgdqhtns 140 1 Indeed indeed RB cord-320959-sgdqhtns 140 2 , , , cord-320959-sgdqhtns 140 3 oral oral JJ cord-320959-sgdqhtns 140 4 supplementation supplementation NN cord-320959-sgdqhtns 140 5 of of IN cord-320959-sgdqhtns 140 6 Vitamin vitamin NN cord-320959-sgdqhtns 140 7 E e NN cord-320959-sgdqhtns 140 8 acetate acetate NN cord-320959-sgdqhtns 140 9 in in IN cord-320959-sgdqhtns 140 10 HIV HIV NNP cord-320959-sgdqhtns 140 11 / / SYM cord-320959-sgdqhtns 140 12 AIDS AIDS NNP cord-320959-sgdqhtns 140 13 patients patient NNS cord-320959-sgdqhtns 140 14 , , , cord-320959-sgdqhtns 140 15 which which WDT cord-320959-sgdqhtns 140 16 is be VBZ cord-320959-sgdqhtns 140 17 readily readily RB cord-320959-sgdqhtns 140 18 converted convert VBN cord-320959-sgdqhtns 140 19 to to IN cord-320959-sgdqhtns 140 20 Vitamin vitamin NN cord-320959-sgdqhtns 140 21 E e NN cord-320959-sgdqhtns 140 22 by by IN cord-320959-sgdqhtns 140 23 cellular cellular JJ cord-320959-sgdqhtns 140 24 esterases esterase NNS cord-320959-sgdqhtns 140 25 , , , cord-320959-sgdqhtns 140 26 has have VBZ cord-320959-sgdqhtns 140 27 been be VBN cord-320959-sgdqhtns 140 28 successful successful JJ cord-320959-sgdqhtns 140 29 in in IN cord-320959-sgdqhtns 140 30 reducing reduce VBG cord-320959-sgdqhtns 140 31 the the DT cord-320959-sgdqhtns 140 32 viral viral JJ cord-320959-sgdqhtns 140 33 load load NN cord-320959-sgdqhtns 140 34 [ [ -LRB- cord-320959-sgdqhtns 140 35 80 80 CD cord-320959-sgdqhtns 140 36 ] ] -RRB- cord-320959-sgdqhtns 140 37 , , , cord-320959-sgdqhtns 140 38 as as IN cord-320959-sgdqhtns 140 39 the the DT cord-320959-sgdqhtns 140 40 molecule molecule NN cord-320959-sgdqhtns 140 41 disrupts disrupt VBZ cord-320959-sgdqhtns 140 42 the the DT cord-320959-sgdqhtns 140 43 tensile tensile JJ cord-320959-sgdqhtns 140 44 two two CD cord-320959-sgdqhtns 140 45 - - HYPH cord-320959-sgdqhtns 140 46 dimensional dimensional JJ cord-320959-sgdqhtns 140 47 L l NN cord-320959-sgdqhtns 140 48 α α NN cord-320959-sgdqhtns 140 49 /L /L . cord-320959-sgdqhtns 140 50 o o NN cord-320959-sgdqhtns 140 51 phase phase NN cord-320959-sgdqhtns 140 52 boundary boundary NN cord-320959-sgdqhtns 140 53 required require VBN cord-320959-sgdqhtns 140 54 for for IN cord-320959-sgdqhtns 140 55 viral viral JJ cord-320959-sgdqhtns 140 56 entry entry NN cord-320959-sgdqhtns 140 57 [ [ -LRB- cord-320959-sgdqhtns 140 58 81 81 CD cord-320959-sgdqhtns 140 59 , , , cord-320959-sgdqhtns 140 60 82 82 CD cord-320959-sgdqhtns 140 61 ] ] -RRB- cord-320959-sgdqhtns 140 62 . . . cord-320959-sgdqhtns 141 1 In in IN cord-320959-sgdqhtns 141 2 membrane membrane NN cord-320959-sgdqhtns 141 3 biophysics biophysic NNS cord-320959-sgdqhtns 141 4 , , , cord-320959-sgdqhtns 141 5 this this DT cord-320959-sgdqhtns 141 6 vitamin vitamin NN cord-320959-sgdqhtns 141 7 is be VBZ cord-320959-sgdqhtns 141 8 classified classify VBN cord-320959-sgdqhtns 141 9 as as IN cord-320959-sgdqhtns 141 10 a a DT cord-320959-sgdqhtns 141 11 linactant linactant JJ cord-320959-sgdqhtns 141 12 [ [ -LRB- cord-320959-sgdqhtns 141 13 83 83 CD cord-320959-sgdqhtns 141 14 ] ] -RRB- cord-320959-sgdqhtns 141 15 , , , cord-320959-sgdqhtns 141 16 which which WDT cord-320959-sgdqhtns 141 17 is be VBZ cord-320959-sgdqhtns 141 18 a a DT cord-320959-sgdqhtns 141 19 20 20 CD cord-320959-sgdqhtns 141 20 two two CD cord-320959-sgdqhtns 141 21 - - HYPH cord-320959-sgdqhtns 141 22 dimensional dimensional JJ cord-320959-sgdqhtns 141 23 counterpart counterpart NN cord-320959-sgdqhtns 141 24 of of IN cord-320959-sgdqhtns 141 25 a a DT cord-320959-sgdqhtns 141 26 surfactant surfactant NN cord-320959-sgdqhtns 141 27 , , , cord-320959-sgdqhtns 141 28 as as IN cord-320959-sgdqhtns 141 29 it -PRON- PRP cord-320959-sgdqhtns 141 30 reduces reduce VBZ cord-320959-sgdqhtns 141 31 the the DT cord-320959-sgdqhtns 141 32 line line NN cord-320959-sgdqhtns 141 33 tension tension NN cord-320959-sgdqhtns 141 34 at at IN cord-320959-sgdqhtns 141 35 the the DT cord-320959-sgdqhtns 141 36 two two CD cord-320959-sgdqhtns 141 37 - - HYPH cord-320959-sgdqhtns 141 38 dimensional dimensional JJ cord-320959-sgdqhtns 141 39 phase phase NN cord-320959-sgdqhtns 141 40 boundaries boundary NNS cord-320959-sgdqhtns 141 41 ( ( -LRB- cord-320959-sgdqhtns 141 42 Fig Fig NNP cord-320959-sgdqhtns 141 43 . . . cord-320959-sgdqhtns 141 44 2a 2a CD cord-320959-sgdqhtns 141 45 ) ) -RRB- cord-320959-sgdqhtns 141 46 . . . cord-320959-sgdqhtns 142 1 In in IN cord-320959-sgdqhtns 142 2 explanation explanation NN cord-320959-sgdqhtns 142 3 , , , cord-320959-sgdqhtns 142 4 when when WRB cord-320959-sgdqhtns 142 5 one one PRP cord-320959-sgdqhtns 142 6 puts put VBZ cord-320959-sgdqhtns 142 7 a a DT cord-320959-sgdqhtns 142 8 drop drop NN cord-320959-sgdqhtns 142 9 of of IN cord-320959-sgdqhtns 142 10 oil oil NN cord-320959-sgdqhtns 142 11 into into IN cord-320959-sgdqhtns 142 12 the the DT cord-320959-sgdqhtns 142 13 water water NN cord-320959-sgdqhtns 142 14 , , , cord-320959-sgdqhtns 142 15 gravity gravity NN cord-320959-sgdqhtns 142 16 and and CC cord-320959-sgdqhtns 142 17 surface surface NN cord-320959-sgdqhtns 142 18 tension tension NN cord-320959-sgdqhtns 142 19 compete compete VBP cord-320959-sgdqhtns 142 20 to to TO cord-320959-sgdqhtns 142 21 generate generate VB cord-320959-sgdqhtns 142 22 the the DT cord-320959-sgdqhtns 142 23 lobular lobular JJ cord-320959-sgdqhtns 142 24 shape shape NN cord-320959-sgdqhtns 142 25 of of IN cord-320959-sgdqhtns 142 26 the the DT cord-320959-sgdqhtns 142 27 droplet droplet NN cord-320959-sgdqhtns 142 28 . . . cord-320959-sgdqhtns 143 1 The the DT cord-320959-sgdqhtns 143 2 addition addition NN cord-320959-sgdqhtns 143 3 of of IN cord-320959-sgdqhtns 143 4 sodium sodium NN cord-320959-sgdqhtns 143 5 dodecyl dodecyl NNP cord-320959-sgdqhtns 143 6 sulfate sulfate NNP cord-320959-sgdqhtns 143 7 ( ( -LRB- cord-320959-sgdqhtns 143 8 SDS SDS NNP cord-320959-sgdqhtns 143 9 ) ) -RRB- cord-320959-sgdqhtns 143 10 , , , cord-320959-sgdqhtns 143 11 a a DT cord-320959-sgdqhtns 143 12 well well RB cord-320959-sgdqhtns 143 13 - - HYPH cord-320959-sgdqhtns 143 14 known know VBN cord-320959-sgdqhtns 143 15 surfactant surfactant NN cord-320959-sgdqhtns 143 16 , , , cord-320959-sgdqhtns 143 17 reduces reduce VBZ cord-320959-sgdqhtns 143 18 the the DT cord-320959-sgdqhtns 143 19 surface surface NN cord-320959-sgdqhtns 143 20 tension tension NN cord-320959-sgdqhtns 143 21 such such JJ cord-320959-sgdqhtns 143 22 that that IN cord-320959-sgdqhtns 143 23 the the DT cord-320959-sgdqhtns 143 24 oil oil NN cord-320959-sgdqhtns 143 25 droplet droplet NN cord-320959-sgdqhtns 143 26 loses lose VBZ cord-320959-sgdqhtns 143 27 its -PRON- PRP$ cord-320959-sgdqhtns 143 28 ability ability NN cord-320959-sgdqhtns 143 29 to to TO cord-320959-sgdqhtns 143 30 maintain maintain VB cord-320959-sgdqhtns 143 31 its -PRON- PRP$ cord-320959-sgdqhtns 143 32 structure structure NN cord-320959-sgdqhtns 143 33 against against IN cord-320959-sgdqhtns 143 34 gravitational gravitational JJ cord-320959-sgdqhtns 143 35 force force NN cord-320959-sgdqhtns 143 36 . . . cord-320959-sgdqhtns 144 1 As as IN cord-320959-sgdqhtns 144 2 a a DT cord-320959-sgdqhtns 144 3 consequence consequence NN cord-320959-sgdqhtns 144 4 , , , cord-320959-sgdqhtns 144 5 oil oil NN cord-320959-sgdqhtns 144 6 emulsifies emulsifie NNS cord-320959-sgdqhtns 144 7 into into IN cord-320959-sgdqhtns 144 8 the the DT cord-320959-sgdqhtns 144 9 water water NN cord-320959-sgdqhtns 144 10 , , , cord-320959-sgdqhtns 144 11 if if IN cord-320959-sgdqhtns 144 12 not not RB cord-320959-sgdqhtns 144 13 become become VB cord-320959-sgdqhtns 144 14 completely completely RB cord-320959-sgdqhtns 144 15 miscible miscible JJ cord-320959-sgdqhtns 144 16 [ [ -LRB- cord-320959-sgdqhtns 144 17 84 84 CD cord-320959-sgdqhtns 144 18 ] ] -RRB- cord-320959-sgdqhtns 144 19 . . . cord-320959-sgdqhtns 145 1 Similarly similarly RB cord-320959-sgdqhtns 145 2 , , , cord-320959-sgdqhtns 145 3 when when WRB cord-320959-sgdqhtns 145 4 one one NN cord-320959-sgdqhtns 145 5 adds add VBZ cord-320959-sgdqhtns 145 6 Vitamin vitamin NN cord-320959-sgdqhtns 145 7 E e NN cord-320959-sgdqhtns 145 8 onto onto IN cord-320959-sgdqhtns 145 9 the the DT cord-320959-sgdqhtns 145 10 lipid lipid NN cord-320959-sgdqhtns 145 11 bilayer bilayer NN cord-320959-sgdqhtns 145 12 exhibiting exhibit VBG cord-320959-sgdqhtns 145 13 L L NNP cord-320959-sgdqhtns 145 14 α α NNP cord-320959-sgdqhtns 145 15 /L /L . cord-320959-sgdqhtns 145 16 o o NN cord-320959-sgdqhtns 145 17 phase phase NN cord-320959-sgdqhtns 145 18 separation separation NN cord-320959-sgdqhtns 145 19 , , , cord-320959-sgdqhtns 145 20 it -PRON- PRP cord-320959-sgdqhtns 145 21 reduces reduce VBZ cord-320959-sgdqhtns 145 22 the the DT cord-320959-sgdqhtns 145 23 line line NN cord-320959-sgdqhtns 145 24 tension tension NN cord-320959-sgdqhtns 145 25 , , , cord-320959-sgdqhtns 145 26 which which WDT cord-320959-sgdqhtns 145 27 competes compete VBZ cord-320959-sgdqhtns 145 28 with with IN cord-320959-sgdqhtns 145 29 entropy entropy NN cord-320959-sgdqhtns 145 30 to to IN cord-320959-sgdqhtns 145 31 5 5 CD cord-320959-sgdqhtns 145 32 form form VB cord-320959-sgdqhtns 145 33 an an DT cord-320959-sgdqhtns 145 34 enlarged enlarged JJ cord-320959-sgdqhtns 145 35 cholesterol cholesterol NN cord-320959-sgdqhtns 145 36 - - HYPH cord-320959-sgdqhtns 145 37 enriched enrich VBN cord-320959-sgdqhtns 145 38 microdomain microdomain NN cord-320959-sgdqhtns 145 39 . . . cord-320959-sgdqhtns 146 1 As as IN cord-320959-sgdqhtns 146 2 it -PRON- PRP cord-320959-sgdqhtns 146 3 has have VBZ cord-320959-sgdqhtns 146 4 been be VBN cord-320959-sgdqhtns 146 5 shown show VBN cord-320959-sgdqhtns 146 6 that that IN cord-320959-sgdqhtns 146 7 the the DT cord-320959-sgdqhtns 146 8 molar molar JJ cord-320959-sgdqhtns 146 9 ratio ratio NN cord-320959-sgdqhtns 146 10 of of IN cord-320959-sgdqhtns 146 11 Vitamin vitamin NN cord-320959-sgdqhtns 146 12 E e NN cord-320959-sgdqhtns 146 13 within within IN cord-320959-sgdqhtns 146 14 a a DT cord-320959-sgdqhtns 146 15 typical typical JJ cord-320959-sgdqhtns 146 16 lipid lipid NN cord-320959-sgdqhtns 146 17 bilayer bilayer NN cord-320959-sgdqhtns 146 18 is be VBZ cord-320959-sgdqhtns 146 19 insufficient insufficient JJ cord-320959-sgdqhtns 146 20 to to TO cord-320959-sgdqhtns 146 21 completely completely RB cord-320959-sgdqhtns 146 22 abolish abolish VB cord-320959-sgdqhtns 146 23 lateral lateral JJ cord-320959-sgdqhtns 146 24 phase phase NN cord-320959-sgdqhtns 146 25 separation separation NN cord-320959-sgdqhtns 146 26 [ [ -LRB- cord-320959-sgdqhtns 146 27 85 85 CD cord-320959-sgdqhtns 146 28 ] ] -RRB- cord-320959-sgdqhtns 146 29 , , , cord-320959-sgdqhtns 146 30 Vitamin vitamin NN cord-320959-sgdqhtns 146 31 E e NN cord-320959-sgdqhtns 146 32 acts act VBZ cord-320959-sgdqhtns 146 33 to to TO cord-320959-sgdqhtns 146 34 reduce reduce VB cord-320959-sgdqhtns 146 35 the the DT cord-320959-sgdqhtns 146 36 size size NN cord-320959-sgdqhtns 146 37 of of IN cord-320959-sgdqhtns 146 38 the the DT cord-320959-sgdqhtns 146 39 microdomain microdomain NN cord-320959-sgdqhtns 146 40 and and CC cord-320959-sgdqhtns 146 41 thereby thereby RB cord-320959-sgdqhtns 146 42 emulsifies emulsify VBZ cord-320959-sgdqhtns 146 43 cholesterol cholesterol NN cord-320959-sgdqhtns 146 44 - - HYPH cord-320959-sgdqhtns 146 45 enriched enrich VBN cord-320959-sgdqhtns 146 46 L l NN cord-320959-sgdqhtns 146 47 o o NN cord-320959-sgdqhtns 146 48 into into IN cord-320959-sgdqhtns 146 49 cholesterol cholesterol NN cord-320959-sgdqhtns 146 50 - - HYPH cord-320959-sgdqhtns 146 51 depleted deplete VBN cord-320959-sgdqhtns 146 52 L l NN cord-320959-sgdqhtns 146 53 α α NN cord-320959-sgdqhtns 146 54 ( ( -LRB- cord-320959-sgdqhtns 146 55 Fig Fig NNP cord-320959-sgdqhtns 146 56 . . . cord-320959-sgdqhtns 146 57 2c 2c NNP cord-320959-sgdqhtns 146 58 ) ) -RRB- cord-320959-sgdqhtns 146 59 . . . cord-320959-sgdqhtns 147 1 Despite despite IN cord-320959-sgdqhtns 147 2 the the DT cord-320959-sgdqhtns 147 3 fact fact NN cord-320959-sgdqhtns 147 4 that that IN cord-320959-sgdqhtns 147 5 the the DT cord-320959-sgdqhtns 147 6 line line NN cord-320959-sgdqhtns 147 7 - - HYPH cord-320959-sgdqhtns 147 8 active active JJ cord-320959-sgdqhtns 147 9 property property NN cord-320959-sgdqhtns 147 10 of of IN cord-320959-sgdqhtns 147 11 Vitamin vitamin NN cord-320959-sgdqhtns 147 12 E e NN cord-320959-sgdqhtns 147 13 acetate acetate NN cord-320959-sgdqhtns 147 14 has have VBZ cord-320959-sgdqhtns 147 15 not not RB cord-320959-sgdqhtns 147 16 yet yet RB cord-320959-sgdqhtns 147 17 been be VBN cord-320959-sgdqhtns 147 18 explicitly explicitly RB cord-320959-sgdqhtns 147 19 tested test VBN cord-320959-sgdqhtns 147 20 , , , cord-320959-sgdqhtns 147 21 the the DT cord-320959-sgdqhtns 147 22 small small JJ cord-320959-sgdqhtns 147 23 size size NN cord-320959-sgdqhtns 147 24 and and CC cord-320959-sgdqhtns 147 25 the the DT cord-320959-sgdqhtns 147 26 abundance abundance NN cord-320959-sgdqhtns 147 27 10 10 CD cord-320959-sgdqhtns 147 28 of of IN cord-320959-sgdqhtns 147 29 ideally ideally RB cord-320959-sgdqhtns 147 30 localized localize VBN cord-320959-sgdqhtns 147 31 nonbonding nonbonding NN cord-320959-sgdqhtns 147 32 electron electron NN cord-320959-sgdqhtns 147 33 donors donor NNS cord-320959-sgdqhtns 147 34 of of IN cord-320959-sgdqhtns 147 35 the the DT cord-320959-sgdqhtns 147 36 ester ester NN cord-320959-sgdqhtns 147 37 moiety moiety NNP cord-320959-sgdqhtns 147 38 provide provide VB cord-320959-sgdqhtns 147 39 ample ample JJ cord-320959-sgdqhtns 147 40 reason reason NN cord-320959-sgdqhtns 147 41 to to TO cord-320959-sgdqhtns 147 42 hypothesize hypothesize VB cord-320959-sgdqhtns 147 43 that that IN cord-320959-sgdqhtns 147 44 the the DT cord-320959-sgdqhtns 147 45 substance substance NN cord-320959-sgdqhtns 147 46 is be VBZ cord-320959-sgdqhtns 147 47 a a DT cord-320959-sgdqhtns 147 48 linactant linactant NN cord-320959-sgdqhtns 147 49 . . . cord-320959-sgdqhtns 148 1 The the DT cord-320959-sgdqhtns 148 2 content content NN cord-320959-sgdqhtns 148 3 of of IN cord-320959-sgdqhtns 148 4 Vitamin vitamin NN cord-320959-sgdqhtns 148 5 E e NN cord-320959-sgdqhtns 148 6 within within IN cord-320959-sgdqhtns 148 7 the the DT cord-320959-sgdqhtns 148 8 lipid lipid NN cord-320959-sgdqhtns 148 9 mixture mixture NN cord-320959-sgdqhtns 148 10 that that WDT cord-320959-sgdqhtns 148 11 is be VBZ cord-320959-sgdqhtns 148 12 sufficient sufficient JJ cord-320959-sgdqhtns 148 13 to to TO cord-320959-sgdqhtns 148 14 function function VB cord-320959-sgdqhtns 148 15 as as IN cord-320959-sgdqhtns 148 16 a a DT cord-320959-sgdqhtns 148 17 potent potent JJ cord-320959-sgdqhtns 148 18 linactant linactant NN cord-320959-sgdqhtns 148 19 is be VBZ cord-320959-sgdqhtns 148 20 typically typically RB cord-320959-sgdqhtns 148 21 below below IN cord-320959-sgdqhtns 148 22 10 10 CD cord-320959-sgdqhtns 148 23 mol% mol% CD cord-320959-sgdqhtns 148 24 [ [ -LRB- cord-320959-sgdqhtns 148 25 79 79 CD cord-320959-sgdqhtns 148 26 , , , cord-320959-sgdqhtns 148 27 85 85 CD cord-320959-sgdqhtns 148 28 ] ] -RRB- cord-320959-sgdqhtns 148 29 , , , cord-320959-sgdqhtns 148 30 which which WDT cord-320959-sgdqhtns 148 31 is be VBZ cord-320959-sgdqhtns 148 32 comparable comparable JJ cord-320959-sgdqhtns 148 33 to to IN cord-320959-sgdqhtns 148 34 that that DT cord-320959-sgdqhtns 148 35 of of IN cord-320959-sgdqhtns 148 36 Vitamin vitamin NN cord-320959-sgdqhtns 148 37 E e NN cord-320959-sgdqhtns 148 38 acetate acetate NN cord-320959-sgdqhtns 148 39 , , , cord-320959-sgdqhtns 148 40 estimated estimate VBN cord-320959-sgdqhtns 148 41 based base VBN cord-320959-sgdqhtns 148 42 on on IN cord-320959-sgdqhtns 148 43 its -PRON- PRP$ cord-320959-sgdqhtns 148 44 concentration concentration NN cord-320959-sgdqhtns 148 45 in in IN cord-320959-sgdqhtns 148 46 BAL bal NN cord-320959-sgdqhtns 148 47 fluid fluid NN cord-320959-sgdqhtns 148 48 samples sample NNS cord-320959-sgdqhtns 148 49 from from IN cord-320959-sgdqhtns 148 50 patients patient NNS cord-320959-sgdqhtns 148 51 with with IN cord-320959-sgdqhtns 148 52 EVALI EVALI NNS cord-320959-sgdqhtns 148 53 . . . cord-320959-sgdqhtns 149 1 15 15 CD cord-320959-sgdqhtns 150 1 An an DT cord-320959-sgdqhtns 150 2 important important JJ cord-320959-sgdqhtns 150 3 consequence consequence NN cord-320959-sgdqhtns 150 4 of of IN cord-320959-sgdqhtns 150 5 the the DT cord-320959-sgdqhtns 150 6 dissemination dissemination NN cord-320959-sgdqhtns 150 7 of of IN cord-320959-sgdqhtns 150 8 the the DT cord-320959-sgdqhtns 150 9 cholesterol cholesterol NN cord-320959-sgdqhtns 150 10 - - HYPH cord-320959-sgdqhtns 150 11 enriched enrich VBN cord-320959-sgdqhtns 150 12 microdomain microdomain NN cord-320959-sgdqhtns 150 13 is be VBZ cord-320959-sgdqhtns 150 14 a a DT cord-320959-sgdqhtns 150 15 profound profound JJ cord-320959-sgdqhtns 150 16 increment increment NN cord-320959-sgdqhtns 150 17 in in IN cord-320959-sgdqhtns 150 18 the the DT cord-320959-sgdqhtns 150 19 surface surface NN cord-320959-sgdqhtns 150 20 viscosity viscosity NN cord-320959-sgdqhtns 150 21 of of IN cord-320959-sgdqhtns 150 22 pulmonary pulmonary JJ cord-320959-sgdqhtns 150 23 surfactants surfactant NNS cord-320959-sgdqhtns 150 24 [ [ -LRB- cord-320959-sgdqhtns 150 25 86 86 CD cord-320959-sgdqhtns 150 26 ] ] -RRB- cord-320959-sgdqhtns 150 27 . . . cord-320959-sgdqhtns 151 1 Lateral lateral JJ cord-320959-sgdqhtns 151 2 phase phase NN cord-320959-sgdqhtns 151 3 separation separation NN cord-320959-sgdqhtns 151 4 is be VBZ cord-320959-sgdqhtns 151 5 an an DT cord-320959-sgdqhtns 151 6 important important JJ cord-320959-sgdqhtns 151 7 source source NN cord-320959-sgdqhtns 151 8 of of IN cord-320959-sgdqhtns 151 9 free free JJ cord-320959-sgdqhtns 151 10 area area NN cord-320959-sgdqhtns 151 11 , , , cord-320959-sgdqhtns 151 12 defined define VBN cord-320959-sgdqhtns 151 13 as as IN cord-320959-sgdqhtns 151 14 the the DT cord-320959-sgdqhtns 151 15 difference difference NN cord-320959-sgdqhtns 151 16 between between IN cord-320959-sgdqhtns 151 17 observed observed JJ cord-320959-sgdqhtns 151 18 and and CC cord-320959-sgdqhtns 151 19 minimum minimum JJ cord-320959-sgdqhtns 151 20 area area NN cord-320959-sgdqhtns 151 21 per per IN cord-320959-sgdqhtns 151 22 molecule molecule NN cord-320959-sgdqhtns 151 23 [ [ -LRB- cord-320959-sgdqhtns 151 24 87 87 CD cord-320959-sgdqhtns 151 25 ] ] -RRB- cord-320959-sgdqhtns 151 26 . . . cord-320959-sgdqhtns 152 1 This this DT cord-320959-sgdqhtns 152 2 is be VBZ cord-320959-sgdqhtns 152 3 analogous analogous JJ cord-320959-sgdqhtns 152 4 to to IN cord-320959-sgdqhtns 152 5 the the DT cord-320959-sgdqhtns 152 6 observation observation NN cord-320959-sgdqhtns 152 7 of of IN cord-320959-sgdqhtns 152 8 reduction reduction NN cord-320959-sgdqhtns 152 9 in in IN cord-320959-sgdqhtns 152 10 the the DT cord-320959-sgdqhtns 152 11 total total JJ cord-320959-sgdqhtns 152 12 volume volume NN cord-320959-sgdqhtns 152 13 after after IN cord-320959-sgdqhtns 152 14 mixing mix VBG cord-320959-sgdqhtns 152 15 ethanol ethanol NN cord-320959-sgdqhtns 152 16 with with IN cord-320959-sgdqhtns 152 17 water water NN cord-320959-sgdqhtns 152 18 . . . cord-320959-sgdqhtns 153 1 In in IN cord-320959-sgdqhtns 153 2 such such PDT cord-320959-sgdqhtns 153 3 a a DT cord-320959-sgdqhtns 153 4 case case NN cord-320959-sgdqhtns 153 5 , , , cord-320959-sgdqhtns 153 6 the the DT cord-320959-sgdqhtns 153 7 phenomenon phenomenon NN cord-320959-sgdqhtns 153 8 can can MD cord-320959-sgdqhtns 153 9 be be VB cord-320959-sgdqhtns 153 10 interpreted interpret VBN cord-320959-sgdqhtns 153 11 as as IN cord-320959-sgdqhtns 153 12 if if IN cord-320959-sgdqhtns 153 13 20 20 CD cord-320959-sgdqhtns 153 14 the the DT cord-320959-sgdqhtns 153 15 free free JJ cord-320959-sgdqhtns 153 16 volume volume NN cord-320959-sgdqhtns 153 17 of of IN cord-320959-sgdqhtns 153 18 each each DT cord-320959-sgdqhtns 153 19 molecule molecule NN cord-320959-sgdqhtns 153 20 has have VBZ cord-320959-sgdqhtns 153 21 decreased decrease VBN cord-320959-sgdqhtns 153 22 following follow VBG cord-320959-sgdqhtns 153 23 mixing mix VBG cord-320959-sgdqhtns 153 24 . . . cord-320959-sgdqhtns 154 1 Similarly similarly RB cord-320959-sgdqhtns 154 2 , , , cord-320959-sgdqhtns 154 3 mixing mix VBG cord-320959-sgdqhtns 154 4 of of IN cord-320959-sgdqhtns 154 5 L l NN cord-320959-sgdqhtns 154 6 o o NN cord-320959-sgdqhtns 154 7 with with IN cord-320959-sgdqhtns 154 8 L L NNP cord-320959-sgdqhtns 154 9 α α NN cord-320959-sgdqhtns 154 10 results result NNS cord-320959-sgdqhtns 154 11 in in IN cord-320959-sgdqhtns 154 12 a a DT cord-320959-sgdqhtns 154 13 substantial substantial JJ cord-320959-sgdqhtns 154 14 decrease decrease NN cord-320959-sgdqhtns 154 15 in in IN cord-320959-sgdqhtns 154 16 the the DT cord-320959-sgdqhtns 154 17 free free JJ cord-320959-sgdqhtns 154 18 area area NN cord-320959-sgdqhtns 154 19 , , , cord-320959-sgdqhtns 154 20 while while IN cord-320959-sgdqhtns 154 21 demixing demixe VBG cord-320959-sgdqhtns 154 22 induces induce VBZ cord-320959-sgdqhtns 154 23 its -PRON- PRP$ cord-320959-sgdqhtns 154 24 subsequent subsequent JJ cord-320959-sgdqhtns 154 25 increase increase NN cord-320959-sgdqhtns 154 26 . . . cord-320959-sgdqhtns 155 1 According accord VBG cord-320959-sgdqhtns 155 2 to to IN cord-320959-sgdqhtns 155 3 the the DT cord-320959-sgdqhtns 155 4 free free JJ cord-320959-sgdqhtns 155 5 area area NN cord-320959-sgdqhtns 155 6 theory theory NN cord-320959-sgdqhtns 155 7 of of IN cord-320959-sgdqhtns 155 8 surface surface NN cord-320959-sgdqhtns 155 9 viscosity viscosity NN cord-320959-sgdqhtns 155 10 [ [ -LRB- cord-320959-sgdqhtns 155 11 88 88 CD cord-320959-sgdqhtns 155 12 ] ] -RRB- cord-320959-sgdqhtns 155 13 , , , cord-320959-sgdqhtns 155 14 surface surface NN cord-320959-sgdqhtns 155 15 viscosity viscosity NN cord-320959-sgdqhtns 155 16 exponentially exponentially RB cord-320959-sgdqhtns 155 17 increases increase VBZ cord-320959-sgdqhtns 155 18 following follow VBG cord-320959-sgdqhtns 155 19 the the DT cord-320959-sgdqhtns 155 20 reduction reduction NN cord-320959-sgdqhtns 155 21 of of IN cord-320959-sgdqhtns 155 22 free free JJ cord-320959-sgdqhtns 155 23 area area NN cord-320959-sgdqhtns 155 24 , , , cord-320959-sgdqhtns 155 25 driven drive VBN cord-320959-sgdqhtns 155 26 by by IN cord-320959-sgdqhtns 155 27 reduced reduce VBN cord-320959-sgdqhtns 155 28 tensile tensile JJ cord-320959-sgdqhtns 155 29 force force NN cord-320959-sgdqhtns 155 30 along along IN cord-320959-sgdqhtns 155 31 the the DT cord-320959-sgdqhtns 155 32 two two CD cord-320959-sgdqhtns 155 33 - - HYPH cord-320959-sgdqhtns 155 34 dimensional dimensional JJ cord-320959-sgdqhtns 155 35 phase phase NN cord-320959-sgdqhtns 155 36 boundaries boundary NNS cord-320959-sgdqhtns 155 37 . . . cord-320959-sgdqhtns 156 1 Indeed indeed RB cord-320959-sgdqhtns 156 2 , , , cord-320959-sgdqhtns 156 3 a a DT cord-320959-sgdqhtns 156 4 mere mere JJ cord-320959-sgdqhtns 156 5 3 3 CD cord-320959-sgdqhtns 156 6 % % NN cord-320959-sgdqhtns 156 7 decrease decrease NN cord-320959-sgdqhtns 156 8 in in IN cord-320959-sgdqhtns 156 9 the the DT cord-320959-sgdqhtns 156 10 free free JJ cord-320959-sgdqhtns 156 11 area area NN cord-320959-sgdqhtns 156 12 resulted result VBD cord-320959-sgdqhtns 156 13 in in IN cord-320959-sgdqhtns 156 14 a a DT cord-320959-sgdqhtns 156 15 striking striking JJ cord-320959-sgdqhtns 156 16 12-fold 12-fold CD cord-320959-sgdqhtns 156 17 increase increase NN cord-320959-sgdqhtns 156 18 in in IN cord-320959-sgdqhtns 156 19 the the DT cord-320959-sgdqhtns 156 20 surface surface NN cord-320959-sgdqhtns 156 21 viscosity viscosity NN cord-320959-sgdqhtns 156 22 of of IN cord-320959-sgdqhtns 156 23 pulmonary pulmonary JJ cord-320959-sgdqhtns 156 24 surfactants surfactant NNS cord-320959-sgdqhtns 156 25 [ [ -LRB- cord-320959-sgdqhtns 156 26 87 87 CD cord-320959-sgdqhtns 156 27 ] ] -RRB- cord-320959-sgdqhtns 156 28 . . . cord-320959-sgdqhtns 157 1 In in IN cord-320959-sgdqhtns 157 2 accordance accordance NN cord-320959-sgdqhtns 157 3 , , , cord-320959-sgdqhtns 157 4 upon upon IN cord-320959-sgdqhtns 157 5 hyperpnea hyperpnea NNP cord-320959-sgdqhtns 157 6 , , , cord-320959-sgdqhtns 157 7 the the DT cord-320959-sgdqhtns 157 8 biological biological JJ cord-320959-sgdqhtns 157 9 system system NN cord-320959-sgdqhtns 157 10 increases increase VBZ cord-320959-sgdqhtns 157 11 free free JJ cord-320959-sgdqhtns 157 12 cholesterol cholesterol NN cord-320959-sgdqhtns 157 13 level level NN cord-320959-sgdqhtns 157 14 in in IN cord-320959-sgdqhtns 157 15 pulmonary pulmonary JJ cord-320959-sgdqhtns 157 16 surfactants surfactant NNS cord-320959-sgdqhtns 157 17 , , , cord-320959-sgdqhtns 157 18 to to TO cord-320959-sgdqhtns 157 19 reduce reduce VB cord-320959-sgdqhtns 157 20 surface surface NN cord-320959-sgdqhtns 157 21 viscosity viscosity NN cord-320959-sgdqhtns 157 22 , , , cord-320959-sgdqhtns 157 23 which which WDT cord-320959-sgdqhtns 157 24 is be VBZ cord-320959-sgdqhtns 157 25 required require VBN cord-320959-sgdqhtns 157 26 for for IN cord-320959-sgdqhtns 157 27 facilitated facilitate VBN cord-320959-sgdqhtns 157 28 respiration respiration NN cord-320959-sgdqhtns 157 29 [ [ -LRB- cord-320959-sgdqhtns 157 30 89 89 CD cord-320959-sgdqhtns 157 31 ] ] -RRB- cord-320959-sgdqhtns 157 32 . . . cord-320959-sgdqhtns 158 1 5 5 LS cord-320959-sgdqhtns 159 1 Similarly similarly RB cord-320959-sgdqhtns 159 2 , , , cord-320959-sgdqhtns 159 3 the the DT cord-320959-sgdqhtns 159 4 reduced reduce VBN cord-320959-sgdqhtns 159 5 free free JJ cord-320959-sgdqhtns 159 6 area area NN cord-320959-sgdqhtns 159 7 following follow VBG cord-320959-sgdqhtns 159 8 the the DT cord-320959-sgdqhtns 159 9 inhalation inhalation NN cord-320959-sgdqhtns 159 10 of of IN cord-320959-sgdqhtns 159 11 Vitamin vitamin NN cord-320959-sgdqhtns 159 12 E e NN cord-320959-sgdqhtns 159 13 acetate acetate NN cord-320959-sgdqhtns 159 14 may may MD cord-320959-sgdqhtns 159 15 considerably considerably RB cord-320959-sgdqhtns 159 16 increase increase VB cord-320959-sgdqhtns 159 17 the the DT cord-320959-sgdqhtns 159 18 surface surface NN cord-320959-sgdqhtns 159 19 viscosity viscosity NN cord-320959-sgdqhtns 159 20 of of IN cord-320959-sgdqhtns 159 21 the the DT cord-320959-sgdqhtns 159 22 pulmonary pulmonary JJ cord-320959-sgdqhtns 159 23 surfactant surfactant NN cord-320959-sgdqhtns 159 24 , , , cord-320959-sgdqhtns 159 25 resulting result VBG cord-320959-sgdqhtns 159 26 in in IN cord-320959-sgdqhtns 159 27 a a DT cord-320959-sgdqhtns 159 28 disrupted disrupt VBN cord-320959-sgdqhtns 159 29 respiratory respiratory JJ cord-320959-sgdqhtns 159 30 compression compression NN cord-320959-sgdqhtns 159 31 - - HYPH cord-320959-sgdqhtns 159 32 expansion expansion NN cord-320959-sgdqhtns 159 33 cycling cycling NN cord-320959-sgdqhtns 159 34 and and CC cord-320959-sgdqhtns 159 35 a a DT cord-320959-sgdqhtns 159 36 subsequent subsequent JJ cord-320959-sgdqhtns 159 37 hypoxemia hypoxemia NN cord-320959-sgdqhtns 159 38 ( ( -LRB- cord-320959-sgdqhtns 159 39 Fig Fig NNP cord-320959-sgdqhtns 159 40 . . . cord-320959-sgdqhtns 159 41 2b 2b NNP cord-320959-sgdqhtns 159 42 ) ) -RRB- cord-320959-sgdqhtns 159 43 . . . cord-320959-sgdqhtns 160 1 In in IN cord-320959-sgdqhtns 160 2 this this DT cord-320959-sgdqhtns 160 3 picture picture NN cord-320959-sgdqhtns 160 4 , , , cord-320959-sgdqhtns 160 5 intraalveolar intraalveolar NN cord-320959-sgdqhtns 160 6 lipid lipid NN cord-320959-sgdqhtns 160 7 - - HYPH cord-320959-sgdqhtns 160 8 laden laden JJ cord-320959-sgdqhtns 160 9 macrophages macrophage NNS cord-320959-sgdqhtns 160 10 are be VBP cord-320959-sgdqhtns 160 11 consequences consequence NNS cord-320959-sgdqhtns 160 12 of of IN cord-320959-sgdqhtns 160 13 hypoxemia hypoxemia NN cord-320959-sgdqhtns 160 14 - - HYPH cord-320959-sgdqhtns 160 15 induced induce VBN cord-320959-sgdqhtns 160 16 excessive excessive JJ cord-320959-sgdqhtns 160 17 intracellular intracellular JJ cord-320959-sgdqhtns 160 18 accumulation accumulation NN cord-320959-sgdqhtns 160 19 of of IN cord-320959-sgdqhtns 160 20 triglycerides triglyceride NNS cord-320959-sgdqhtns 160 21 [ [ -LRB- cord-320959-sgdqhtns 160 22 90 90 CD cord-320959-sgdqhtns 160 23 ] ] -RRB- cord-320959-sgdqhtns 160 24 , , , cord-320959-sgdqhtns 160 25 and and CC cord-320959-sgdqhtns 160 26 extensive extensive JJ cord-320959-sgdqhtns 160 27 vacuolization vacuolization NN cord-320959-sgdqhtns 160 28 , , , cord-320959-sgdqhtns 160 29 10 10 CD cord-320959-sgdqhtns 160 30 multinucleation multinucleation NN cord-320959-sgdqhtns 160 31 , , , cord-320959-sgdqhtns 160 32 and and CC cord-320959-sgdqhtns 160 33 reactive reactive JJ cord-320959-sgdqhtns 160 34 hyperplasia hyperplasia NN cord-320959-sgdqhtns 160 35 observed observe VBN cord-320959-sgdqhtns 160 36 in in IN cord-320959-sgdqhtns 160 37 type type NN cord-320959-sgdqhtns 160 38 II ii CD cord-320959-sgdqhtns 160 39 alveolar alveolar NN cord-320959-sgdqhtns 160 40 pneumocytes pneumocyte NNS cord-320959-sgdqhtns 160 41 are be VBP cord-320959-sgdqhtns 160 42 products product NNS cord-320959-sgdqhtns 160 43 of of IN cord-320959-sgdqhtns 160 44 an an DT cord-320959-sgdqhtns 160 45 extensive extensive JJ cord-320959-sgdqhtns 160 46 tissue tissue NN cord-320959-sgdqhtns 160 47 hypoxia hypoxia NN cord-320959-sgdqhtns 160 48 [ [ -LRB- cord-320959-sgdqhtns 160 49 91 91 CD cord-320959-sgdqhtns 160 50 , , , cord-320959-sgdqhtns 160 51 92 92 CD cord-320959-sgdqhtns 160 52 ] ] -RRB- cord-320959-sgdqhtns 160 53 . . . cord-320959-sgdqhtns 161 1 Taking take VBG cord-320959-sgdqhtns 161 2 into into IN cord-320959-sgdqhtns 161 3 account account NN cord-320959-sgdqhtns 161 4 that that IN cord-320959-sgdqhtns 161 5 the the DT cord-320959-sgdqhtns 161 6 pulmonary pulmonary NN cord-320959-sgdqhtns 161 7 - - HYPH cord-320959-sgdqhtns 161 8 associated associate VBN cord-320959-sgdqhtns 161 9 surfactant surfactant NN cord-320959-sgdqhtns 161 10 protein protein NN cord-320959-sgdqhtns 161 11 B B NNP cord-320959-sgdqhtns 161 12 ( ( -LRB- cord-320959-sgdqhtns 161 13 SP SP NNP cord-320959-sgdqhtns 161 14 - - HYPH cord-320959-sgdqhtns 161 15 B B NNP cord-320959-sgdqhtns 161 16 ) ) -RRB- cord-320959-sgdqhtns 161 17 often often RB cord-320959-sgdqhtns 161 18 cooperates cooperate VBZ cord-320959-sgdqhtns 161 19 with with IN cord-320959-sgdqhtns 161 20 cholesterol cholesterol NN cord-320959-sgdqhtns 161 21 in in IN cord-320959-sgdqhtns 161 22 reducing reduce VBG cord-320959-sgdqhtns 161 23 the the DT cord-320959-sgdqhtns 161 24 surface surface NN cord-320959-sgdqhtns 161 25 viscosity viscosity NN cord-320959-sgdqhtns 161 26 of of IN cord-320959-sgdqhtns 161 27 pulmonary pulmonary JJ cord-320959-sgdqhtns 161 28 surfactants surfactant NNS cord-320959-sgdqhtns 161 29 during during IN cord-320959-sgdqhtns 161 30 respiratory respiratory JJ cord-320959-sgdqhtns 161 31 compression compression NN cord-320959-sgdqhtns 161 32 - - HYPH cord-320959-sgdqhtns 161 33 expansion expansion NN cord-320959-sgdqhtns 161 34 cycling cycling NN cord-320959-sgdqhtns 161 35 [ [ -LRB- cord-320959-sgdqhtns 161 36 86 86 CD cord-320959-sgdqhtns 161 37 ] ] -RRB- cord-320959-sgdqhtns 161 38 , , , cord-320959-sgdqhtns 161 39 other other JJ cord-320959-sgdqhtns 161 40 than than IN cord-320959-sgdqhtns 161 41 its -PRON- PRP$ cord-320959-sgdqhtns 161 42 known know VBN cord-320959-sgdqhtns 161 43 role role NN cord-320959-sgdqhtns 161 44 in in IN cord-320959-sgdqhtns 161 45 the the DT cord-320959-sgdqhtns 161 46 reduction reduction NN cord-320959-sgdqhtns 161 47 of of IN cord-320959-sgdqhtns 161 48 surface surface NN cord-320959-sgdqhtns 161 49 tension tension NN cord-320959-sgdqhtns 161 50 in in IN cord-320959-sgdqhtns 161 51 the the DT cord-320959-sgdqhtns 161 52 steady steady JJ cord-320959-sgdqhtns 161 53 state state NN cord-320959-sgdqhtns 161 54 , , , cord-320959-sgdqhtns 161 55 it -PRON- PRP cord-320959-sgdqhtns 161 56 is be VBZ cord-320959-sgdqhtns 161 57 worth worth JJ cord-320959-sgdqhtns 161 58 to to TO cord-320959-sgdqhtns 161 59 note note VB cord-320959-sgdqhtns 161 60 that that IN cord-320959-sgdqhtns 161 61 the the DT cord-320959-sgdqhtns 161 62 15 15 CD cord-320959-sgdqhtns 161 63 partial partial JJ cord-320959-sgdqhtns 161 64 deficiency deficiency NN cord-320959-sgdqhtns 161 65 of of IN cord-320959-sgdqhtns 161 66 the the DT cord-320959-sgdqhtns 161 67 protein protein NN cord-320959-sgdqhtns 161 68 results result NNS cord-320959-sgdqhtns 161 69 in in IN cord-320959-sgdqhtns 161 70 a a DT cord-320959-sgdqhtns 161 71 respiratory respiratory JJ cord-320959-sgdqhtns 161 72 distress distress NN cord-320959-sgdqhtns 161 73 analogous analogous JJ cord-320959-sgdqhtns 161 74 to to IN cord-320959-sgdqhtns 161 75 those those DT cord-320959-sgdqhtns 161 76 observed observe VBN cord-320959-sgdqhtns 161 77 in in IN cord-320959-sgdqhtns 161 78 patients patient NNS cord-320959-sgdqhtns 161 79 with with IN cord-320959-sgdqhtns 161 80 EVALI EVALI NNS cord-320959-sgdqhtns 161 81 [ [ -LRB- cord-320959-sgdqhtns 161 82 93 93 CD cord-320959-sgdqhtns 161 83 ] ] -RRB- cord-320959-sgdqhtns 161 84 . . . cord-320959-sgdqhtns 162 1 In in IN cord-320959-sgdqhtns 162 2 sum sum NN cord-320959-sgdqhtns 162 3 , , , cord-320959-sgdqhtns 162 4 vaporized vaporize VBD cord-320959-sgdqhtns 162 5 Vitamin vitamin NN cord-320959-sgdqhtns 162 6 E e NN cord-320959-sgdqhtns 162 7 acetate acetate NN cord-320959-sgdqhtns 162 8 , , , cord-320959-sgdqhtns 162 9 a a DT cord-320959-sgdqhtns 162 10 thermostable thermostable JJ cord-320959-sgdqhtns 162 11 derivative derivative NN cord-320959-sgdqhtns 162 12 of of IN cord-320959-sgdqhtns 162 13 the the DT cord-320959-sgdqhtns 162 14 well well RB cord-320959-sgdqhtns 162 15 - - HYPH cord-320959-sgdqhtns 162 16 established establish VBN cord-320959-sgdqhtns 162 17 linactant linactant NN cord-320959-sgdqhtns 162 18 , , , cord-320959-sgdqhtns 162 19 may may MD cord-320959-sgdqhtns 162 20 substantially substantially RB cord-320959-sgdqhtns 162 21 increase increase VB cord-320959-sgdqhtns 162 22 the the DT cord-320959-sgdqhtns 162 23 surface surface NN cord-320959-sgdqhtns 162 24 viscosity viscosity NN cord-320959-sgdqhtns 162 25 of of IN cord-320959-sgdqhtns 162 26 pulmonary pulmonary JJ cord-320959-sgdqhtns 162 27 surfactants surfactant NNS cord-320959-sgdqhtns 162 28 and and CC cord-320959-sgdqhtns 162 29 thereby thereby RB cord-320959-sgdqhtns 162 30 confer confer VB cord-320959-sgdqhtns 162 31 the the DT cord-320959-sgdqhtns 162 32 pathogenesis pathogenesis NN cord-320959-sgdqhtns 162 33 of of IN cord-320959-sgdqhtns 162 34 EVALI EVALI NNS cord-320959-sgdqhtns 162 35 . . . cord-320959-sgdqhtns 163 1 20 20 CD cord-320959-sgdqhtns 164 1 Evaluating evaluate VBG cord-320959-sgdqhtns 164 2 the the DT cord-320959-sgdqhtns 164 3 hypothesis hypothesis NN cord-320959-sgdqhtns 164 4 The the DT cord-320959-sgdqhtns 164 5 above above RB cord-320959-sgdqhtns 164 6 - - HYPH cord-320959-sgdqhtns 164 7 described describe VBN cord-320959-sgdqhtns 164 8 biological biological JJ cord-320959-sgdqhtns 164 9 actions action NNS cord-320959-sgdqhtns 164 10 of of IN cord-320959-sgdqhtns 164 11 Vitamin vitamin NN cord-320959-sgdqhtns 164 12 E e NN cord-320959-sgdqhtns 164 13 derivatives derivative NNS cord-320959-sgdqhtns 164 14 are be VBP cord-320959-sgdqhtns 164 15 closely closely RB cord-320959-sgdqhtns 164 16 intertwined intertwine VBN cord-320959-sgdqhtns 164 17 to to IN cord-320959-sgdqhtns 164 18 each each DT cord-320959-sgdqhtns 164 19 other other JJ cord-320959-sgdqhtns 164 20 [ [ -LRB- cord-320959-sgdqhtns 164 21 83 83 CD cord-320959-sgdqhtns 164 22 , , , cord-320959-sgdqhtns 164 23 94 94 CD cord-320959-sgdqhtns 164 24 ] ] -RRB- cord-320959-sgdqhtns 164 25 , , , cord-320959-sgdqhtns 164 26 and and CC cord-320959-sgdqhtns 164 27 the the DT cord-320959-sgdqhtns 164 28 effect effect NN cord-320959-sgdqhtns 164 29 of of IN cord-320959-sgdqhtns 164 30 Vitamin vitamin NN cord-320959-sgdqhtns 164 31 E e NN cord-320959-sgdqhtns 164 32 acetate acetate NN cord-320959-sgdqhtns 164 33 on on IN cord-320959-sgdqhtns 164 34 the the DT cord-320959-sgdqhtns 164 35 pulmonary pulmonary JJ cord-320959-sgdqhtns 164 36 system system NN cord-320959-sgdqhtns 164 37 in in IN cord-320959-sgdqhtns 164 38 patients patient NNS cord-320959-sgdqhtns 164 39 with with IN cord-320959-sgdqhtns 164 40 EVALI EVALI NNS cord-320959-sgdqhtns 164 41 is be VBZ cord-320959-sgdqhtns 164 42 likely likely JJ cord-320959-sgdqhtns 164 43 to to TO cord-320959-sgdqhtns 164 44 be be VB cord-320959-sgdqhtns 164 45 the the DT cord-320959-sgdqhtns 164 46 sum sum NN cord-320959-sgdqhtns 164 47 of of IN cord-320959-sgdqhtns 164 48 all all PDT cord-320959-sgdqhtns 164 49 these these DT cord-320959-sgdqhtns 164 50 actions action NNS cord-320959-sgdqhtns 164 51 , , , cord-320959-sgdqhtns 164 52 rather rather RB cord-320959-sgdqhtns 164 53 than than IN cord-320959-sgdqhtns 164 54 originating originate VBG cord-320959-sgdqhtns 164 55 from from IN cord-320959-sgdqhtns 164 56 a a DT cord-320959-sgdqhtns 164 57 single single JJ cord-320959-sgdqhtns 164 58 action action NN cord-320959-sgdqhtns 164 59 of of IN cord-320959-sgdqhtns 164 60 the the DT cord-320959-sgdqhtns 164 61 vitamin vitamin NN cord-320959-sgdqhtns 164 62 derivative derivative JJ cord-320959-sgdqhtns 164 63 . . . cord-320959-sgdqhtns 165 1 For for IN cord-320959-sgdqhtns 165 2 instance instance NN cord-320959-sgdqhtns 165 3 , , , cord-320959-sgdqhtns 165 4 cholesterol cholesterol NN cord-320959-sgdqhtns 165 5 - - HYPH cord-320959-sgdqhtns 165 6 enriched enrich VBN cord-320959-sgdqhtns 165 7 microdomains microdomain NNS cord-320959-sgdqhtns 165 8 , , , cord-320959-sgdqhtns 165 9 or or CC cord-320959-sgdqhtns 165 10 lipid lipid NN cord-320959-sgdqhtns 165 11 rafts raft NNS cord-320959-sgdqhtns 165 12 [ [ -LRB- cord-320959-sgdqhtns 165 13 95 95 CD cord-320959-sgdqhtns 165 14 ] ] -RRB- cord-320959-sgdqhtns 165 15 , , , cord-320959-sgdqhtns 165 16 are be VBP cord-320959-sgdqhtns 165 17 involved involve VBN cord-320959-sgdqhtns 165 18 in in IN cord-320959-sgdqhtns 165 19 a a DT cord-320959-sgdqhtns 165 20 plethora plethora NN cord-320959-sgdqhtns 165 21 of of IN cord-320959-sgdqhtns 165 22 cellular cellular JJ cord-320959-sgdqhtns 165 23 activities activity NNS cord-320959-sgdqhtns 165 24 , , , cord-320959-sgdqhtns 165 25 including include VBG cord-320959-sgdqhtns 165 26 PKCα PKCα NNS cord-320959-sgdqhtns 165 27 [ [ -LRB- cord-320959-sgdqhtns 165 28 96 96 CD cord-320959-sgdqhtns 165 29 ] ] -RRB- cord-320959-sgdqhtns 165 30 and and CC cord-320959-sgdqhtns 165 31 5-LO 5-lo CD cord-320959-sgdqhtns 165 32 signaling signal VBG cord-320959-sgdqhtns 165 33 [ [ -LRB- cord-320959-sgdqhtns 165 34 97 97 CD cord-320959-sgdqhtns 165 35 ] ] -RRB- cord-320959-sgdqhtns 165 36 . . . cord-320959-sgdqhtns 166 1 As as IN cord-320959-sgdqhtns 166 2 a a DT cord-320959-sgdqhtns 166 3 consequence consequence NN cord-320959-sgdqhtns 166 4 , , , cord-320959-sgdqhtns 166 5 it -PRON- PRP cord-320959-sgdqhtns 166 6 is be VBZ cord-320959-sgdqhtns 166 7 worth worth JJ cord-320959-sgdqhtns 166 8 to to TO cord-320959-sgdqhtns 166 9 note note VB cord-320959-sgdqhtns 166 10 that that IN cord-320959-sgdqhtns 166 11 the the DT cord-320959-sgdqhtns 166 12 evaluation evaluation NN cord-320959-sgdqhtns 166 13 of of IN cord-320959-sgdqhtns 166 14 these these DT cord-320959-sgdqhtns 166 15 hypotheses hypothesis NNS cord-320959-sgdqhtns 166 16 should should MD cord-320959-sgdqhtns 166 17 focus focus VB cord-320959-sgdqhtns 166 18 on on IN cord-320959-sgdqhtns 166 19 identifying identify VBG cord-320959-sgdqhtns 166 20 the the DT cord-320959-sgdqhtns 166 21 major major JJ cord-320959-sgdqhtns 166 22 driving driving NN cord-320959-sgdqhtns 166 23 force force NN cord-320959-sgdqhtns 166 24 for for IN cord-320959-sgdqhtns 166 25 the the DT cord-320959-sgdqhtns 166 26 pathogenesis pathogenesis NN cord-320959-sgdqhtns 166 27 of of IN cord-320959-sgdqhtns 166 28 EVALI EVALI NNS cord-320959-sgdqhtns 166 29 , , , cord-320959-sgdqhtns 166 30 rather rather RB cord-320959-sgdqhtns 166 31 than than IN cord-320959-sgdqhtns 166 32 a a DT cord-320959-sgdqhtns 166 33 sole sole JJ cord-320959-sgdqhtns 166 34 cause cause NN cord-320959-sgdqhtns 166 35 , , , cord-320959-sgdqhtns 166 36 5 5 CD cord-320959-sgdqhtns 166 37 which which WDT cord-320959-sgdqhtns 166 38 most most RBS cord-320959-sgdqhtns 166 39 likely likely RB cord-320959-sgdqhtns 166 40 does do VBZ cord-320959-sgdqhtns 166 41 not not RB cord-320959-sgdqhtns 166 42 exist exist VB cord-320959-sgdqhtns 166 43 . . . cord-320959-sgdqhtns 167 1 To to TO cord-320959-sgdqhtns 167 2 evaluate evaluate VB cord-320959-sgdqhtns 167 3 whether whether IN cord-320959-sgdqhtns 167 4 the the DT cord-320959-sgdqhtns 167 5 line line NN cord-320959-sgdqhtns 167 6 - - HYPH cord-320959-sgdqhtns 167 7 active active JJ cord-320959-sgdqhtns 167 8 property property NN cord-320959-sgdqhtns 167 9 of of IN cord-320959-sgdqhtns 167 10 Vitamin vitamin NN cord-320959-sgdqhtns 167 11 E e NN cord-320959-sgdqhtns 167 12 acetate acetate NN cord-320959-sgdqhtns 167 13 is be VBZ cord-320959-sgdqhtns 167 14 driving drive VBG cord-320959-sgdqhtns 167 15 the the DT cord-320959-sgdqhtns 167 16 pathogenesis pathogenesis NN cord-320959-sgdqhtns 167 17 of of IN cord-320959-sgdqhtns 167 18 EVALI EVALI NNS cord-320959-sgdqhtns 167 19 , , , cord-320959-sgdqhtns 167 20 we -PRON- PRP cord-320959-sgdqhtns 167 21 must must MD cord-320959-sgdqhtns 167 22 answer answer VB cord-320959-sgdqhtns 167 23 the the DT cord-320959-sgdqhtns 167 24 following follow VBG cord-320959-sgdqhtns 167 25 questions question NNS cord-320959-sgdqhtns 167 26 . . . cord-320959-sgdqhtns 168 1 First first RB cord-320959-sgdqhtns 168 2 , , , cord-320959-sgdqhtns 168 3 is be VBZ cord-320959-sgdqhtns 168 4 Vitamin vitamin NN cord-320959-sgdqhtns 168 5 E e NN cord-320959-sgdqhtns 168 6 acetate acetate NN cord-320959-sgdqhtns 168 7 , , , cord-320959-sgdqhtns 168 8 like like IN cord-320959-sgdqhtns 168 9 d d NN cord-320959-sgdqhtns 168 10 - - HYPH cord-320959-sgdqhtns 168 11 α α NN cord-320959-sgdqhtns 168 12 - - HYPH cord-320959-sgdqhtns 168 13 tocopherol tocopherol NN cord-320959-sgdqhtns 168 14 , , , cord-320959-sgdqhtns 168 15 a a DT cord-320959-sgdqhtns 168 16 potent potent JJ cord-320959-sgdqhtns 168 17 linactant linactant NN cord-320959-sgdqhtns 168 18 ? ? . cord-320959-sgdqhtns 169 1 If if IN cord-320959-sgdqhtns 169 2 it -PRON- PRP cord-320959-sgdqhtns 169 3 is be VBZ cord-320959-sgdqhtns 169 4 , , , cord-320959-sgdqhtns 169 5 to to TO cord-320959-sgdqhtns 169 6 what what WDT cord-320959-sgdqhtns 169 7 extent extent NN cord-320959-sgdqhtns 169 8 does do VBZ cord-320959-sgdqhtns 169 9 the the DT cord-320959-sgdqhtns 169 10 substance substance NN cord-320959-sgdqhtns 169 11 reduce reduce VB cord-320959-sgdqhtns 169 12 the the DT cord-320959-sgdqhtns 169 13 line line NN cord-320959-sgdqhtns 169 14 tension tension NN cord-320959-sgdqhtns 169 15 at at IN cord-320959-sgdqhtns 169 16 the the DT cord-320959-sgdqhtns 169 17 twodimensional twodimensional NNP cord-320959-sgdqhtns 169 18 phase phase NN cord-320959-sgdqhtns 169 19 boundaries boundary NNS cord-320959-sgdqhtns 169 20 and and CC cord-320959-sgdqhtns 169 21 increase increase VB cord-320959-sgdqhtns 169 22 the the DT cord-320959-sgdqhtns 169 23 surface surface NN cord-320959-sgdqhtns 169 24 viscosity viscosity NN cord-320959-sgdqhtns 169 25 ? ? . cord-320959-sgdqhtns 170 1 Molecular molecular JJ cord-320959-sgdqhtns 170 2 dynamics dynamic NNS cord-320959-sgdqhtns 170 3 10 10 CD cord-320959-sgdqhtns 170 4 simulations simulation NNS cord-320959-sgdqhtns 170 5 , , , cord-320959-sgdqhtns 170 6 such such JJ cord-320959-sgdqhtns 170 7 as as IN cord-320959-sgdqhtns 170 8 those those DT cord-320959-sgdqhtns 170 9 previously previously RB cord-320959-sgdqhtns 170 10 introduced introduce VBN cord-320959-sgdqhtns 170 11 by by IN cord-320959-sgdqhtns 170 12 Rosetti Rosetti NNP cord-320959-sgdqhtns 170 13 and and CC cord-320959-sgdqhtns 170 14 colleagues colleague NNS cord-320959-sgdqhtns 170 15 [ [ -LRB- cord-320959-sgdqhtns 170 16 98 98 CD cord-320959-sgdqhtns 170 17 ] ] -RRB- cord-320959-sgdqhtns 170 18 , , , cord-320959-sgdqhtns 170 19 would would MD cord-320959-sgdqhtns 170 20 particularly particularly RB cord-320959-sgdqhtns 170 21 be be VB cord-320959-sgdqhtns 170 22 useful useful JJ cord-320959-sgdqhtns 170 23 , , , cord-320959-sgdqhtns 170 24 as as IN cord-320959-sgdqhtns 170 25 they -PRON- PRP cord-320959-sgdqhtns 170 26 enable enable VBP cord-320959-sgdqhtns 170 27 us -PRON- PRP cord-320959-sgdqhtns 170 28 to to TO cord-320959-sgdqhtns 170 29 roughly roughly RB cord-320959-sgdqhtns 170 30 estimate estimate VB cord-320959-sgdqhtns 170 31 the the DT cord-320959-sgdqhtns 170 32 fold fold JJ cord-320959-sgdqhtns 170 33 change change NN cord-320959-sgdqhtns 170 34 in in IN cord-320959-sgdqhtns 170 35 the the DT cord-320959-sgdqhtns 170 36 surface surface NN cord-320959-sgdqhtns 170 37 viscosity viscosity NN cord-320959-sgdqhtns 170 38 of of IN cord-320959-sgdqhtns 170 39 pulmonary pulmonary JJ cord-320959-sgdqhtns 170 40 surfactants surfactant NNS cord-320959-sgdqhtns 170 41 and and CC cord-320959-sgdqhtns 170 42 thereby thereby RB cord-320959-sgdqhtns 170 43 to to TO cord-320959-sgdqhtns 170 44 evaluate evaluate VB cord-320959-sgdqhtns 170 45 the the DT cord-320959-sgdqhtns 170 46 validity validity NN cord-320959-sgdqhtns 170 47 of of IN cord-320959-sgdqhtns 170 48 the the DT cord-320959-sgdqhtns 170 49 hypothesis hypothesis NN cord-320959-sgdqhtns 170 50 . . . cord-320959-sgdqhtns 171 1 Second second RB cord-320959-sgdqhtns 171 2 , , , cord-320959-sgdqhtns 171 3 are be VBP cord-320959-sgdqhtns 171 4 linactants linactant NNS cord-320959-sgdqhtns 171 5 , , , cord-320959-sgdqhtns 171 6 in in IN cord-320959-sgdqhtns 171 7 general general JJ cord-320959-sgdqhtns 171 8 , , , cord-320959-sgdqhtns 171 9 capable capable JJ cord-320959-sgdqhtns 171 10 of of IN cord-320959-sgdqhtns 171 11 inducing induce VBG cord-320959-sgdqhtns 171 12 respiratory respiratory JJ cord-320959-sgdqhtns 171 13 distress distress NN cord-320959-sgdqhtns 171 14 when when WRB cord-320959-sgdqhtns 171 15 inhaled inhale VBN cord-320959-sgdqhtns 171 16 through through IN cord-320959-sgdqhtns 171 17 ecigarettes ecigarette NNS cord-320959-sgdqhtns 171 18 ? ? . cord-320959-sgdqhtns 172 1 One one CD cord-320959-sgdqhtns 172 2 obvious obvious JJ cord-320959-sgdqhtns 172 3 experiment experiment NN cord-320959-sgdqhtns 172 4 that that WDT cord-320959-sgdqhtns 172 5 must must MD cord-320959-sgdqhtns 172 6 be be VB cord-320959-sgdqhtns 172 7 done do VBN cord-320959-sgdqhtns 172 8 is be VBZ cord-320959-sgdqhtns 172 9 the the DT cord-320959-sgdqhtns 172 10 repeated repeat VBN cord-320959-sgdqhtns 172 11 inhalation inhalation NN cord-320959-sgdqhtns 172 12 of of IN cord-320959-sgdqhtns 172 13 hybrid hybrid JJ cord-320959-sgdqhtns 172 14 lipids lipid NNS cord-320959-sgdqhtns 172 15 15 15 CD cord-320959-sgdqhtns 172 16 in in IN cord-320959-sgdqhtns 172 17 murine murine JJ cord-320959-sgdqhtns 172 18 models model NNS cord-320959-sgdqhtns 172 19 . . . cord-320959-sgdqhtns 173 1 Hybrid hybrid JJ cord-320959-sgdqhtns 173 2 lipids lipid NNS cord-320959-sgdqhtns 173 3 , , , cord-320959-sgdqhtns 173 4 which which WDT cord-320959-sgdqhtns 173 5 are be VBP cord-320959-sgdqhtns 173 6 phospholipids phospholipid NNS cord-320959-sgdqhtns 173 7 that that WDT cord-320959-sgdqhtns 173 8 contain contain VBP cord-320959-sgdqhtns 173 9 both both DT cord-320959-sgdqhtns 173 10 saturated saturated JJ cord-320959-sgdqhtns 173 11 and and CC cord-320959-sgdqhtns 173 12 unsaturated unsaturated JJ cord-320959-sgdqhtns 173 13 acyl acyl NN cord-320959-sgdqhtns 173 14 chains chain NNS cord-320959-sgdqhtns 173 15 , , , cord-320959-sgdqhtns 173 16 are be VBP cord-320959-sgdqhtns 173 17 one one CD cord-320959-sgdqhtns 173 18 of of IN cord-320959-sgdqhtns 173 19 the the DT cord-320959-sgdqhtns 173 20 most most RBS cord-320959-sgdqhtns 173 21 widely widely RB cord-320959-sgdqhtns 173 22 accepted accept VBN cord-320959-sgdqhtns 173 23 class class NN cord-320959-sgdqhtns 173 24 of of IN cord-320959-sgdqhtns 173 25 linactants linactant NNS cord-320959-sgdqhtns 173 26 [ [ -LRB- cord-320959-sgdqhtns 173 27 98 98 CD cord-320959-sgdqhtns 173 28 ] ] -RRB- cord-320959-sgdqhtns 174 1 [ [ -LRB- cord-320959-sgdqhtns 174 2 99 99 CD cord-320959-sgdqhtns 174 3 ] ] -RRB- cord-320959-sgdqhtns 174 4 [ [ -LRB- cord-320959-sgdqhtns 174 5 100 100 CD cord-320959-sgdqhtns 174 6 ] ] -RRB- cord-320959-sgdqhtns 174 7 [ [ -LRB- cord-320959-sgdqhtns 174 8 101 101 CD cord-320959-sgdqhtns 174 9 ] ] -RRB- cord-320959-sgdqhtns 174 10 . . . cord-320959-sgdqhtns 175 1 As as IN cord-320959-sgdqhtns 175 2 a a DT cord-320959-sgdqhtns 175 3 consequence consequence NN cord-320959-sgdqhtns 175 4 , , , cord-320959-sgdqhtns 175 5 repeated repeat VBN cord-320959-sgdqhtns 175 6 inhalation inhalation NN cord-320959-sgdqhtns 175 7 of of IN cord-320959-sgdqhtns 175 8 hybrid hybrid JJ cord-320959-sgdqhtns 175 9 lipids lipid NNS cord-320959-sgdqhtns 175 10 , , , cord-320959-sgdqhtns 175 11 analogous analogous JJ cord-320959-sgdqhtns 175 12 to to IN cord-320959-sgdqhtns 175 13 those those DT cord-320959-sgdqhtns 175 14 attempted attempt VBN cord-320959-sgdqhtns 175 15 by by IN cord-320959-sgdqhtns 175 16 Bhat Bhat NNP cord-320959-sgdqhtns 175 17 and and CC cord-320959-sgdqhtns 175 18 colleagues colleague NNS cord-320959-sgdqhtns 175 19 , , , cord-320959-sgdqhtns 175 20 should should MD cord-320959-sgdqhtns 175 21 induce induce VB cord-320959-sgdqhtns 175 22 similar similar JJ cord-320959-sgdqhtns 175 23 histological histological JJ cord-320959-sgdqhtns 175 24 signs sign NNS cord-320959-sgdqhtns 175 25 , , , cord-320959-sgdqhtns 175 26 for for IN cord-320959-sgdqhtns 175 27 the the DT cord-320959-sgdqhtns 175 28 hypothesis hypothesis NN cord-320959-sgdqhtns 175 29 to to TO cord-320959-sgdqhtns 175 30 hold hold VB cord-320959-sgdqhtns 175 31 . . . cord-320959-sgdqhtns 176 1 To to TO cord-320959-sgdqhtns 176 2 rule rule VB cord-320959-sgdqhtns 176 3 out out RP cord-320959-sgdqhtns 176 4 the the DT cord-320959-sgdqhtns 176 5 potential potential JJ cord-320959-sgdqhtns 176 6 role role NN cord-320959-sgdqhtns 176 7 of of IN cord-320959-sgdqhtns 176 8 Vitamin vitamin NN cord-320959-sgdqhtns 176 9 E e NN cord-320959-sgdqhtns 176 10 acetate acetate NN cord-320959-sgdqhtns 176 11 as as IN cord-320959-sgdqhtns 176 12 an an DT cord-320959-sgdqhtns 176 13 inducer inducer NN cord-320959-sgdqhtns 176 14 of of IN cord-320959-sgdqhtns 176 15 gel gel NN cord-320959-sgdqhtns 176 16 - - HYPH cord-320959-sgdqhtns 176 17 liquid liquid NN cord-320959-sgdqhtns 176 18 crystalline crystalline NN cord-320959-sgdqhtns 176 19 phase phase NN cord-320959-sgdqhtns 176 20 transition transition NN cord-320959-sgdqhtns 176 21 , , , cord-320959-sgdqhtns 176 22 rescue rescue NN cord-320959-sgdqhtns 176 23 20 20 CD cord-320959-sgdqhtns 176 24 experiments experiment NNS cord-320959-sgdqhtns 176 25 using use VBG cord-320959-sgdqhtns 176 26 an an DT cord-320959-sgdqhtns 176 27 inhalation inhalation NN cord-320959-sgdqhtns 176 28 setup setup NN cord-320959-sgdqhtns 176 29 for for IN cord-320959-sgdqhtns 176 30 dimethyl dimethyl NN cord-320959-sgdqhtns 176 31 sulfoxide sulfoxide NN cord-320959-sgdqhtns 176 32 ( ( -LRB- cord-320959-sgdqhtns 176 33 DMSO DMSO NNP cord-320959-sgdqhtns 176 34 ) ) -RRB- cord-320959-sgdqhtns 176 35 , , , cord-320959-sgdqhtns 176 36 which which WDT cord-320959-sgdqhtns 176 37 abrogates abrogate VBZ cord-320959-sgdqhtns 176 38 gelliquid gelliquid NNP cord-320959-sgdqhtns 176 39 crystalline crystalline NN cord-320959-sgdqhtns 176 40 phase phase NN cord-320959-sgdqhtns 176 41 transition transition NN cord-320959-sgdqhtns 176 42 [ [ -LRB- cord-320959-sgdqhtns 176 43 102 102 CD cord-320959-sgdqhtns 176 44 ] ] -RRB- cord-320959-sgdqhtns 176 45 , , , cord-320959-sgdqhtns 176 46 can can MD cord-320959-sgdqhtns 176 47 be be VB cord-320959-sgdqhtns 176 48 attempted attempt VBN cord-320959-sgdqhtns 176 49 . . . cord-320959-sgdqhtns 177 1 To to TO cord-320959-sgdqhtns 177 2 rule rule VB cord-320959-sgdqhtns 177 3 out out RP cord-320959-sgdqhtns 177 4 the the DT cord-320959-sgdqhtns 177 5 possibility possibility NN cord-320959-sgdqhtns 177 6 that that IN cord-320959-sgdqhtns 177 7 Vitamin vitamin NN cord-320959-sgdqhtns 177 8 E e NN cord-320959-sgdqhtns 177 9 acetate acetate NN cord-320959-sgdqhtns 177 10 drives drive VBZ cord-320959-sgdqhtns 177 11 the the DT cord-320959-sgdqhtns 177 12 pathogenesis pathogenesis NN cord-320959-sgdqhtns 177 13 of of IN cord-320959-sgdqhtns 177 14 EVALI EVALI NNS cord-320959-sgdqhtns 177 15 through through IN cord-320959-sgdqhtns 177 16 modulating modulate VBG cord-320959-sgdqhtns 177 17 DGK DGK NNP cord-320959-sgdqhtns 177 18 - - HYPH cord-320959-sgdqhtns 177 19 PKC PKC NNP cord-320959-sgdqhtns 177 20 or or CC cord-320959-sgdqhtns 177 21 PXR PXR NNP cord-320959-sgdqhtns 177 22 signaling signal VBG cord-320959-sgdqhtns 177 23 , , , cord-320959-sgdqhtns 177 24 Vitamin vitamin NN cord-320959-sgdqhtns 177 25 E e NN cord-320959-sgdqhtns 177 26 acetate acetate NN cord-320959-sgdqhtns 177 27 inhalation inhalation NN cord-320959-sgdqhtns 177 28 experiment experiment NN cord-320959-sgdqhtns 177 29 using use VBG cord-320959-sgdqhtns 177 30 either either CC cord-320959-sgdqhtns 177 31 PKCα PKCα NNS cord-320959-sgdqhtns 177 32 [ [ -LRB- cord-320959-sgdqhtns 177 33 103 103 CD cord-320959-sgdqhtns 177 34 ] ] -RRB- cord-320959-sgdqhtns 177 35 or or CC cord-320959-sgdqhtns 177 36 PXR pxr NN cord-320959-sgdqhtns 177 37 knockout knockout NN cord-320959-sgdqhtns 177 38 mice mouse NNS cord-320959-sgdqhtns 177 39 [ [ -LRB- cord-320959-sgdqhtns 177 40 104 104 CD cord-320959-sgdqhtns 177 41 ] ] -RRB- cord-320959-sgdqhtns 177 42 can can MD cord-320959-sgdqhtns 177 43 be be VB cord-320959-sgdqhtns 177 44 pursued pursue VBN cord-320959-sgdqhtns 177 45 . . . cord-320959-sgdqhtns 178 1 Characterization characterization NN cord-320959-sgdqhtns 178 2 of of IN cord-320959-sgdqhtns 178 3 the the DT cord-320959-sgdqhtns 178 4 lipid lipid NN cord-320959-sgdqhtns 178 5 composition composition NN cord-320959-sgdqhtns 178 6 of of IN cord-320959-sgdqhtns 178 7 the the DT cord-320959-sgdqhtns 178 8 intraalveolar intraalveolar NNP cord-320959-sgdqhtns 178 9 lipidladen lipidladen NNP cord-320959-sgdqhtns 178 10 macrophages macrophage NNS cord-320959-sgdqhtns 178 11 is be VBZ cord-320959-sgdqhtns 178 12 also also RB cord-320959-sgdqhtns 178 13 crucial crucial JJ cord-320959-sgdqhtns 178 14 , , , cord-320959-sgdqhtns 178 15 as as IN cord-320959-sgdqhtns 178 16 it -PRON- PRP cord-320959-sgdqhtns 178 17 may may MD cord-320959-sgdqhtns 178 18 assist assist VB cord-320959-sgdqhtns 178 19 us -PRON- PRP cord-320959-sgdqhtns 178 20 to to TO cord-320959-sgdqhtns 178 21 rule rule VB cord-320959-sgdqhtns 178 22 out out RP cord-320959-sgdqhtns 178 23 the the DT cord-320959-sgdqhtns 178 24 hypothesis hypothesis NN cord-320959-sgdqhtns 178 25 that that IN cord-320959-sgdqhtns 178 26 an an DT cord-320959-sgdqhtns 178 27 acute acute JJ cord-320959-sgdqhtns 178 28 respiratory respiratory JJ cord-320959-sgdqhtns 178 29 distress distress NN cord-320959-sgdqhtns 178 30 associated associate VBN cord-320959-sgdqhtns 178 31 with with IN cord-320959-sgdqhtns 178 32 EVALI EVALI NNP cord-320959-sgdqhtns 178 33 is be VBZ cord-320959-sgdqhtns 178 34 indeed indeed RB cord-320959-sgdqhtns 178 35 a a DT cord-320959-sgdqhtns 178 36 form form NN cord-320959-sgdqhtns 178 37 of of IN cord-320959-sgdqhtns 178 38 ELP ELP NNP cord-320959-sgdqhtns 178 39 . . . cord-320959-sgdqhtns 179 1 Lastly lastly RB cord-320959-sgdqhtns 179 2 , , , cord-320959-sgdqhtns 179 3 as as IN cord-320959-sgdqhtns 179 4 we -PRON- PRP cord-320959-sgdqhtns 179 5 still still RB cord-320959-sgdqhtns 179 6 suffer suffer VBP cord-320959-sgdqhtns 179 7 from from IN cord-320959-sgdqhtns 179 8 the the DT cord-320959-sgdqhtns 179 9 lack lack NN cord-320959-sgdqhtns 179 10 of of IN cord-320959-sgdqhtns 179 11 characterization characterization NN cord-320959-sgdqhtns 179 12 of of IN cord-320959-sgdqhtns 179 13 the the DT cord-320959-sgdqhtns 179 14 type type NN cord-320959-sgdqhtns 179 15 of of IN cord-320959-sgdqhtns 179 16 injury injury NN cord-320959-sgdqhtns 179 17 in in IN cord-320959-sgdqhtns 179 18 EVALI EVALI NNP cord-320959-sgdqhtns 179 19 , , , cord-320959-sgdqhtns 179 20 I -PRON- PRP cord-320959-sgdqhtns 179 21 propose propose VBP cord-320959-sgdqhtns 179 22 an an DT cord-320959-sgdqhtns 179 23 RNA RNA NNP cord-320959-sgdqhtns 179 24 sequencing sequencing NN cord-320959-sgdqhtns 179 25 5 5 CD cord-320959-sgdqhtns 179 26 ( ( -LRB- cord-320959-sgdqhtns 179 27 RNA RNA NNP cord-320959-sgdqhtns 179 28 - - HYPH cord-320959-sgdqhtns 179 29 seq seq NNP cord-320959-sgdqhtns 179 30 ) ) -RRB- cord-320959-sgdqhtns 179 31 experiment experiment NN cord-320959-sgdqhtns 179 32 for for IN cord-320959-sgdqhtns 179 33 lung lung NN cord-320959-sgdqhtns 179 34 tissues tissue NNS cord-320959-sgdqhtns 179 35 obtained obtain VBN cord-320959-sgdqhtns 179 36 from from IN cord-320959-sgdqhtns 179 37 murine murine JJ cord-320959-sgdqhtns 179 38 models model NNS cord-320959-sgdqhtns 179 39 of of IN cord-320959-sgdqhtns 179 40 EVALI EVALI NNS cord-320959-sgdqhtns 179 41 [ [ -LRB- cord-320959-sgdqhtns 179 42 42 42 CD cord-320959-sgdqhtns 179 43 ] ] -RRB- cord-320959-sgdqhtns 179 44 . . . cord-320959-sgdqhtns 180 1 Analyses analysis NNS cord-320959-sgdqhtns 180 2 on on IN cord-320959-sgdqhtns 180 3 the the DT cord-320959-sgdqhtns 180 4 level level NN cord-320959-sgdqhtns 180 5 of of IN cord-320959-sgdqhtns 180 6 transcripts transcript NNS cord-320959-sgdqhtns 180 7 associated associate VBN cord-320959-sgdqhtns 180 8 with with IN cord-320959-sgdqhtns 180 9 the the DT cord-320959-sgdqhtns 180 10 biological biological JJ cord-320959-sgdqhtns 180 11 action action NN cord-320959-sgdqhtns 180 12 of of IN cord-320959-sgdqhtns 180 13 the the DT cord-320959-sgdqhtns 180 14 vitamin vitamin NN cord-320959-sgdqhtns 180 15 , , , cord-320959-sgdqhtns 180 16 such such JJ cord-320959-sgdqhtns 180 17 as as IN cord-320959-sgdqhtns 180 18 cytochrome cytochrome NN cord-320959-sgdqhtns 180 19 P450 p450 JJ cord-320959-sgdqhtns 180 20 monooxygenase monooxygenase NN cord-320959-sgdqhtns 180 21 genes gene NNS cord-320959-sgdqhtns 180 22 , , , cord-320959-sgdqhtns 180 23 hypoxia hypoxia NN cord-320959-sgdqhtns 180 24 - - HYPH cord-320959-sgdqhtns 180 25 inducible inducible JJ cord-320959-sgdqhtns 180 26 factor factor NN cord-320959-sgdqhtns 180 27 1 1 CD cord-320959-sgdqhtns 180 28 ( ( -LRB- cord-320959-sgdqhtns 180 29 HIF-1 HIF-1 NNP cord-320959-sgdqhtns 180 30 ) ) -RRB- cord-320959-sgdqhtns 180 31 , , , cord-320959-sgdqhtns 180 32 and and CC cord-320959-sgdqhtns 180 33 NRF2 NRF2 NNP cord-320959-sgdqhtns 180 34 , , , cord-320959-sgdqhtns 180 35 as as RB cord-320959-sgdqhtns 180 36 well well RB cord-320959-sgdqhtns 180 37 as as IN cord-320959-sgdqhtns 180 38 gene gene NN cord-320959-sgdqhtns 180 39 ontology ontology NN cord-320959-sgdqhtns 180 40 analyses analysis NNS cord-320959-sgdqhtns 180 41 would would MD cord-320959-sgdqhtns 180 42 greatly greatly RB cord-320959-sgdqhtns 180 43 assist assist VB cord-320959-sgdqhtns 180 44 us -PRON- PRP cord-320959-sgdqhtns 180 45 to to TO cord-320959-sgdqhtns 180 46 better better RB cord-320959-sgdqhtns 180 47 define define VB cord-320959-sgdqhtns 180 48 the the DT cord-320959-sgdqhtns 180 49 pathology pathology NN cord-320959-sgdqhtns 180 50 of of IN cord-320959-sgdqhtns 180 51 the the DT cord-320959-sgdqhtns 180 52 new new JJ cord-320959-sgdqhtns 180 53 respiratory respiratory JJ cord-320959-sgdqhtns 180 54 disorder disorder NN cord-320959-sgdqhtns 180 55 . . . cord-320959-sgdqhtns 181 1 RNA RNA NNP cord-320959-sgdqhtns 181 2 - - HYPH cord-320959-sgdqhtns 181 3 seq seq NN cord-320959-sgdqhtns 181 4 experiment experiment NN cord-320959-sgdqhtns 181 5 would would MD cord-320959-sgdqhtns 181 6 also also RB cord-320959-sgdqhtns 181 7 allow allow VB cord-320959-sgdqhtns 181 8 us -PRON- PRP cord-320959-sgdqhtns 181 9 to to TO cord-320959-sgdqhtns 181 10 develop develop VB cord-320959-sgdqhtns 181 11 reliable reliable JJ cord-320959-sgdqhtns 181 12 biomarkers biomarker NNS cord-320959-sgdqhtns 181 13 for for IN cord-320959-sgdqhtns 181 14 10 10 CD cord-320959-sgdqhtns 181 15 EVALI EVALI NNS cord-320959-sgdqhtns 181 16 to to TO cord-320959-sgdqhtns 181 17 better better RB cord-320959-sgdqhtns 181 18 assist assist VB cord-320959-sgdqhtns 181 19 health health NN cord-320959-sgdqhtns 181 20 care care NN cord-320959-sgdqhtns 181 21 providers provider NNS cord-320959-sgdqhtns 181 22 in in IN cord-320959-sgdqhtns 181 23 the the DT cord-320959-sgdqhtns 181 24 differential differential JJ cord-320959-sgdqhtns 181 25 diagnosis diagnosis NN cord-320959-sgdqhtns 181 26 of of IN cord-320959-sgdqhtns 181 27 the the DT cord-320959-sgdqhtns 181 28 vaping vaping NN cord-320959-sgdqhtns 181 29 - - HYPH cord-320959-sgdqhtns 181 30 induced induce VBN cord-320959-sgdqhtns 181 31 respiratory respiratory JJ cord-320959-sgdqhtns 181 32 disorder disorder NN cord-320959-sgdqhtns 181 33 against against IN cord-320959-sgdqhtns 181 34 viral viral JJ cord-320959-sgdqhtns 181 35 infections infection NNS cord-320959-sgdqhtns 181 36 . . . cord-320959-sgdqhtns 182 1 Living live VBG cord-320959-sgdqhtns 182 2 in in IN cord-320959-sgdqhtns 182 3 the the DT cord-320959-sgdqhtns 182 4 era era NN cord-320959-sgdqhtns 182 5 of of IN cord-320959-sgdqhtns 182 6 the the DT cord-320959-sgdqhtns 182 7 pandemic pandemic JJ cord-320959-sgdqhtns 182 8 outbreak outbreak NN cord-320959-sgdqhtns 182 9 of of IN cord-320959-sgdqhtns 182 10 the the DT cord-320959-sgdqhtns 182 11 coronavirus coronavirus NN cord-320959-sgdqhtns 182 12 disease disease NN cord-320959-sgdqhtns 182 13 2019 2019 CD cord-320959-sgdqhtns 182 14 ( ( -LRB- cord-320959-sgdqhtns 182 15 COVID-19 COVID-19 NNP cord-320959-sgdqhtns 182 16 ) ) -RRB- cord-320959-sgdqhtns 182 17 , , , cord-320959-sgdqhtns 182 18 wherein wherein WRB cord-320959-sgdqhtns 182 19 tens ten NNS cord-320959-sgdqhtns 182 20 of of IN cord-320959-sgdqhtns 182 21 millions million NNS cord-320959-sgdqhtns 182 22 of of IN cord-320959-sgdqhtns 182 23 people people NNS cord-320959-sgdqhtns 182 24 worldwide worldwide RB cord-320959-sgdqhtns 182 25 are be VBP cord-320959-sgdqhtns 182 26 being be VBG cord-320959-sgdqhtns 182 27 hospitalized hospitalize VBN cord-320959-sgdqhtns 182 28 with with IN cord-320959-sgdqhtns 182 29 symptoms symptom NNS cord-320959-sgdqhtns 182 30 often often RB cord-320959-sgdqhtns 182 31 indistinguishable indistinguishable JJ cord-320959-sgdqhtns 182 32 from from IN cord-320959-sgdqhtns 182 33 those those DT cord-320959-sgdqhtns 182 34 of of IN cord-320959-sgdqhtns 182 35 EVALI EVALI NNS cord-320959-sgdqhtns 182 36 [ [ -LRB- cord-320959-sgdqhtns 182 37 105 105 CD cord-320959-sgdqhtns 182 38 , , , cord-320959-sgdqhtns 182 39 106 106 CD cord-320959-sgdqhtns 182 40 ] ] -RRB- cord-320959-sgdqhtns 182 41 , , , cord-320959-sgdqhtns 182 42 establishing establish VBG cord-320959-sgdqhtns 182 43 diagnostic diagnostic JJ cord-320959-sgdqhtns 182 44 biomarkers biomarker NNS cord-320959-sgdqhtns 182 45 for for IN cord-320959-sgdqhtns 182 46 EVALI EVALI NNS cord-320959-sgdqhtns 182 47 would would MD cord-320959-sgdqhtns 182 48 particularly particularly RB cord-320959-sgdqhtns 182 49 be be VB cord-320959-sgdqhtns 182 50 valuable valuable JJ cord-320959-sgdqhtns 182 51 . . . cord-320959-sgdqhtns 183 1 In in IN cord-320959-sgdqhtns 183 2 summary summary NN cord-320959-sgdqhtns 183 3 , , , cord-320959-sgdqhtns 183 4 I -PRON- PRP cord-320959-sgdqhtns 183 5 discussed discuss VBD cord-320959-sgdqhtns 183 6 several several JJ cord-320959-sgdqhtns 183 7 possible possible JJ cord-320959-sgdqhtns 183 8 mechanisms mechanism NNS cord-320959-sgdqhtns 183 9 by by IN cord-320959-sgdqhtns 183 10 which which WDT cord-320959-sgdqhtns 183 11 Vitamin vitamin NN cord-320959-sgdqhtns 183 12 E e NN cord-320959-sgdqhtns 183 13 acetate acetate NN cord-320959-sgdqhtns 183 14 may may MD cord-320959-sgdqhtns 183 15 drive drive VB cord-320959-sgdqhtns 183 16 the the DT cord-320959-sgdqhtns 183 17 pathogenesis pathogenesis NN cord-320959-sgdqhtns 183 18 of of IN cord-320959-sgdqhtns 183 19 EVALI EVALI NNS cord-320959-sgdqhtns 183 20 and and CC cord-320959-sgdqhtns 183 21 specifically specifically RB cord-320959-sgdqhtns 183 22 advocated advocate VBD cord-320959-sgdqhtns 183 23 the the DT cord-320959-sgdqhtns 183 24 role role NN cord-320959-sgdqhtns 183 25 of of IN cord-320959-sgdqhtns 183 26 Vitamin vitamin NN cord-320959-sgdqhtns 183 27 E e NN cord-320959-sgdqhtns 183 28 acetate acetate NN cord-320959-sgdqhtns 183 29 as as IN cord-320959-sgdqhtns 183 30 a a DT cord-320959-sgdqhtns 183 31 linactant linactant NN cord-320959-sgdqhtns 183 32 ( ( -LRB- cord-320959-sgdqhtns 183 33 Table table NN cord-320959-sgdqhtns 183 34 1 1 CD cord-320959-sgdqhtns 183 35 ) ) -RRB- cord-320959-sgdqhtns 183 36 . . . cord-320959-sgdqhtns 184 1 Based base VBN cord-320959-sgdqhtns 184 2 on on IN cord-320959-sgdqhtns 184 3 recent recent JJ cord-320959-sgdqhtns 184 4 discoveries discovery NNS cord-320959-sgdqhtns 184 5 from from IN cord-320959-sgdqhtns 184 6 the the DT cord-320959-sgdqhtns 184 7 field field NN cord-320959-sgdqhtns 184 8 of of IN cord-320959-sgdqhtns 184 9 membrane membrane NN cord-320959-sgdqhtns 184 10 biophysics biophysic NNS cord-320959-sgdqhtns 184 11 , , , cord-320959-sgdqhtns 184 12 I -PRON- PRP cord-320959-sgdqhtns 184 13 proposed propose VBD cord-320959-sgdqhtns 184 14 that that IN cord-320959-sgdqhtns 184 15 5 5 CD cord-320959-sgdqhtns 184 16 the the DT cord-320959-sgdqhtns 184 17 alleged allege VBN cord-320959-sgdqhtns 184 18 linactivity linactivity NN cord-320959-sgdqhtns 184 19 of of IN cord-320959-sgdqhtns 184 20 Vitamin vitamin NN cord-320959-sgdqhtns 184 21 E e NN cord-320959-sgdqhtns 184 22 acetate acetate NN cord-320959-sgdqhtns 184 23 , , , cord-320959-sgdqhtns 184 24 a a DT cord-320959-sgdqhtns 184 25 thermostable thermostable JJ cord-320959-sgdqhtns 184 26 derivative derivative NN cord-320959-sgdqhtns 184 27 of of IN cord-320959-sgdqhtns 184 28 a a DT cord-320959-sgdqhtns 184 29 well well RB cord-320959-sgdqhtns 184 30 - - HYPH cord-320959-sgdqhtns 184 31 established establish VBN cord-320959-sgdqhtns 184 32 linactant linactant NN cord-320959-sgdqhtns 184 33 , , , cord-320959-sgdqhtns 184 34 significantly significantly RB cord-320959-sgdqhtns 184 35 increases increase VBZ cord-320959-sgdqhtns 184 36 the the DT cord-320959-sgdqhtns 184 37 surface surface NN cord-320959-sgdqhtns 184 38 viscosity viscosity NN cord-320959-sgdqhtns 184 39 of of IN cord-320959-sgdqhtns 184 40 pulmonary pulmonary JJ cord-320959-sgdqhtns 184 41 surfactants surfactant NNS cord-320959-sgdqhtns 184 42 in in IN cord-320959-sgdqhtns 184 43 the the DT cord-320959-sgdqhtns 184 44 alveoli alveolus NNS cord-320959-sgdqhtns 184 45 to to TO cord-320959-sgdqhtns 184 46 confer confer VB cord-320959-sgdqhtns 184 47 acute acute JJ cord-320959-sgdqhtns 184 48 respiratory respiratory JJ cord-320959-sgdqhtns 184 49 distress distress NN cord-320959-sgdqhtns 184 50 associated associate VBN cord-320959-sgdqhtns 184 51 with with IN cord-320959-sgdqhtns 184 52 EVALI EVALI NNS cord-320959-sgdqhtns 184 53 . . . cord-320959-sgdqhtns 185 1 This this DT cord-320959-sgdqhtns 185 2 hypothesis hypothesis NN cord-320959-sgdqhtns 185 3 leads lead VBZ cord-320959-sgdqhtns 185 4 to to IN cord-320959-sgdqhtns 185 5 new new JJ cord-320959-sgdqhtns 185 6 possible possible JJ cord-320959-sgdqhtns 185 7 medication medication NN cord-320959-sgdqhtns 185 8 approaches approach NNS cord-320959-sgdqhtns 185 9 for for IN cord-320959-sgdqhtns 185 10 the the DT cord-320959-sgdqhtns 185 11 new new JJ cord-320959-sgdqhtns 185 12 pulmonary pulmonary JJ cord-320959-sgdqhtns 185 13 disease disease NN cord-320959-sgdqhtns 185 14 . . . cord-320959-sgdqhtns 186 1 If if IN cord-320959-sgdqhtns 186 2 it -PRON- PRP cord-320959-sgdqhtns 186 3 is be VBZ cord-320959-sgdqhtns 186 4 true true JJ cord-320959-sgdqhtns 186 5 that that IN cord-320959-sgdqhtns 186 6 the the DT cord-320959-sgdqhtns 186 7 line line NN cord-320959-sgdqhtns 186 8 - - HYPH cord-320959-sgdqhtns 186 9 active active JJ cord-320959-sgdqhtns 186 10 property property NN cord-320959-sgdqhtns 186 11 of of IN cord-320959-sgdqhtns 186 12 the the DT cord-320959-sgdqhtns 186 13 vitamin vitamin NN cord-320959-sgdqhtns 186 14 derivative derivative NN cord-320959-sgdqhtns 186 15 is be VBZ cord-320959-sgdqhtns 186 16 what what WP cord-320959-sgdqhtns 186 17 is be VBZ cord-320959-sgdqhtns 186 18 causing cause VBG cord-320959-sgdqhtns 186 19 the the DT cord-320959-sgdqhtns 186 20 disease disease NN cord-320959-sgdqhtns 186 21 , , , cord-320959-sgdqhtns 186 22 supplementation supplementation NN cord-320959-sgdqhtns 186 23 of of IN cord-320959-sgdqhtns 186 24 pulmonary pulmonary JJ cord-320959-sgdqhtns 186 25 surfactants surfactant NNS cord-320959-sgdqhtns 186 26 10 10 CD cord-320959-sgdqhtns 186 27 as as RB cord-320959-sgdqhtns 186 28 well well RB cord-320959-sgdqhtns 186 29 as as IN cord-320959-sgdqhtns 186 30 corticosteroid corticosteroid NN cord-320959-sgdqhtns 186 31 treatments treatment NNS cord-320959-sgdqhtns 186 32 should should MD cord-320959-sgdqhtns 186 33 be be VB cord-320959-sgdqhtns 186 34 valid valid JJ cord-320959-sgdqhtns 186 35 . . . cord-320959-sgdqhtns 187 1 To to TO cord-320959-sgdqhtns 187 2 reduce reduce VB cord-320959-sgdqhtns 187 3 the the DT cord-320959-sgdqhtns 187 4 elevated elevated JJ cord-320959-sgdqhtns 187 5 viscosity viscosity NN cord-320959-sgdqhtns 187 6 of of IN cord-320959-sgdqhtns 187 7 pulmonary pulmonary JJ cord-320959-sgdqhtns 187 8 surfactants surfactant NNS cord-320959-sgdqhtns 187 9 , , , cord-320959-sgdqhtns 187 10 pulmonary pulmonary JJ cord-320959-sgdqhtns 187 11 surfactants surfactant NNS cord-320959-sgdqhtns 187 12 which which WDT cord-320959-sgdqhtns 187 13 retain retain VBP cord-320959-sgdqhtns 187 14 a a DT cord-320959-sgdqhtns 187 15 moderate moderate JJ cord-320959-sgdqhtns 187 16 level level NN cord-320959-sgdqhtns 187 17 of of IN cord-320959-sgdqhtns 187 18 cholesterol cholesterol NN cord-320959-sgdqhtns 187 19 , , , cord-320959-sgdqhtns 187 20 such such JJ cord-320959-sgdqhtns 187 21 as as IN cord-320959-sgdqhtns 187 22 Infasurf Infasurf NNP cord-320959-sgdqhtns 187 23 [ [ -LRB- cord-320959-sgdqhtns 187 24 107 107 CD cord-320959-sgdqhtns 187 25 ] ] -RRB- cord-320959-sgdqhtns 187 26 , , , cord-320959-sgdqhtns 187 27 may may MD cord-320959-sgdqhtns 187 28 be be VB cord-320959-sgdqhtns 187 29 recommended recommend VBN cord-320959-sgdqhtns 187 30 for for IN cord-320959-sgdqhtns 187 31 use use NN cord-320959-sgdqhtns 187 32 . . . cord-320959-sgdqhtns 188 1 In in IN cord-320959-sgdqhtns 188 2 addition addition NN cord-320959-sgdqhtns 188 3 , , , cord-320959-sgdqhtns 188 4 in in IN cord-320959-sgdqhtns 188 5 a a DT cord-320959-sgdqhtns 188 6 biophysical biophysical JJ cord-320959-sgdqhtns 188 7 perspective perspective NN cord-320959-sgdqhtns 188 8 , , , cord-320959-sgdqhtns 188 9 since since IN cord-320959-sgdqhtns 188 10 the the DT cord-320959-sgdqhtns 188 11 entropy entropy NN cord-320959-sgdqhtns 188 12 component component NN cord-320959-sgdqhtns 188 13 of of IN cord-320959-sgdqhtns 188 14 the the DT cord-320959-sgdqhtns 188 15 free free JJ cord-320959-sgdqhtns 188 16 energy energy NN cord-320959-sgdqhtns 188 17 , , , cord-320959-sgdqhtns 188 18 which which WDT cord-320959-sgdqhtns 188 19 is be VBZ cord-320959-sgdqhtns 188 20 proportional proportional JJ cord-320959-sgdqhtns 188 21 to to IN cord-320959-sgdqhtns 188 22 the the DT cord-320959-sgdqhtns 188 23 temperature temperature NN cord-320959-sgdqhtns 188 24 of of IN cord-320959-sgdqhtns 188 25 the the DT cord-320959-sgdqhtns 188 26 system system NN cord-320959-sgdqhtns 188 27 , , , cord-320959-sgdqhtns 188 28 works work VBZ cord-320959-sgdqhtns 188 29 against against IN cord-320959-sgdqhtns 188 30 lateral lateral JJ cord-320959-sgdqhtns 188 31 phase phase NN cord-320959-sgdqhtns 188 32 separation separation NN cord-320959-sgdqhtns 188 33 in in IN cord-320959-sgdqhtns 188 34 regular regular JJ cord-320959-sgdqhtns 188 35 solutions solution NNS cord-320959-sgdqhtns 188 36 [ [ -LRB- cord-320959-sgdqhtns 188 37 108 108 CD cord-320959-sgdqhtns 188 38 , , , cord-320959-sgdqhtns 188 39 109 109 CD cord-320959-sgdqhtns 188 40 ] ] -RRB- cord-320959-sgdqhtns 188 41 , , , cord-320959-sgdqhtns 188 42 one one PRP cord-320959-sgdqhtns 188 43 can can MD cord-320959-sgdqhtns 188 44 reverse reverse VB cord-320959-sgdqhtns 188 45 the the DT cord-320959-sgdqhtns 188 46 effects effect NNS cord-320959-sgdqhtns 188 47 15 15 CD cord-320959-sgdqhtns 188 48 of of IN cord-320959-sgdqhtns 188 49 Vitamin vitamin NN cord-320959-sgdqhtns 188 50 E e NN cord-320959-sgdqhtns 188 51 acetate acetate NN cord-320959-sgdqhtns 188 52 by by IN cord-320959-sgdqhtns 188 53 slightly slightly RB cord-320959-sgdqhtns 188 54 lowering lower VBG cord-320959-sgdqhtns 188 55 the the DT cord-320959-sgdqhtns 188 56 temperature temperature NN cord-320959-sgdqhtns 188 57 of of IN cord-320959-sgdqhtns 188 58 the the DT cord-320959-sgdqhtns 188 59 system system NN cord-320959-sgdqhtns 188 60 . . . cord-320959-sgdqhtns 189 1 Controlled control VBN cord-320959-sgdqhtns 189 2 hypothermia hypothermia NN cord-320959-sgdqhtns 189 3 to to TO cord-320959-sgdqhtns 189 4 rescue rescue VB cord-320959-sgdqhtns 189 5 lateral lateral JJ cord-320959-sgdqhtns 189 6 phase phase NN cord-320959-sgdqhtns 189 7 separation separation NN cord-320959-sgdqhtns 189 8 and and CC cord-320959-sgdqhtns 189 9 thereby thereby RB cord-320959-sgdqhtns 189 10 reduce reduce VB cord-320959-sgdqhtns 189 11 surface surface NN cord-320959-sgdqhtns 189 12 viscosity viscosity NN cord-320959-sgdqhtns 189 13 , , , cord-320959-sgdqhtns 189 14 as as IN cord-320959-sgdqhtns 189 15 introduced introduce VBN cord-320959-sgdqhtns 189 16 by by IN cord-320959-sgdqhtns 189 17 Autilio Autilio NNP cord-320959-sgdqhtns 189 18 and and CC cord-320959-sgdqhtns 189 19 colleagues colleague NNS cord-320959-sgdqhtns 189 20 [ [ -LRB- cord-320959-sgdqhtns 189 21 110 110 CD cord-320959-sgdqhtns 189 22 ] ] -RRB- cord-320959-sgdqhtns 189 23 , , , cord-320959-sgdqhtns 189 24 might may MD cord-320959-sgdqhtns 189 25 be be VB cord-320959-sgdqhtns 189 26 a a DT cord-320959-sgdqhtns 189 27 useful useful JJ cord-320959-sgdqhtns 189 28 way way NN cord-320959-sgdqhtns 189 29 to to TO cord-320959-sgdqhtns 189 30 manage manage VB cord-320959-sgdqhtns 189 31 acute acute JJ cord-320959-sgdqhtns 189 32 respiratory respiratory JJ cord-320959-sgdqhtns 189 33 distress distress NN cord-320959-sgdqhtns 189 34 syndrome syndrome NN cord-320959-sgdqhtns 189 35 associated associate VBN cord-320959-sgdqhtns 189 36 with with IN cord-320959-sgdqhtns 189 37 EVALI EVALI NNS cord-320959-sgdqhtns 189 38 . . . cord-320959-sgdqhtns 190 1 The the DT cord-320959-sgdqhtns 190 2 current current JJ cord-320959-sgdqhtns 190 3 outbreak outbreak NN cord-320959-sgdqhtns 190 4 of of IN cord-320959-sgdqhtns 190 5 EVALI EVALI NNP cord-320959-sgdqhtns 190 6 is be VBZ cord-320959-sgdqhtns 190 7 an an DT cord-320959-sgdqhtns 190 8 emerging emerge VBG cord-320959-sgdqhtns 190 9 crisis crisis NN cord-320959-sgdqhtns 190 10 affecting affect VBG cord-320959-sgdqhtns 190 11 a a DT cord-320959-sgdqhtns 190 12 great great JJ cord-320959-sgdqhtns 190 13 portion portion NN cord-320959-sgdqhtns 190 14 of of IN cord-320959-sgdqhtns 190 15 the the DT cord-320959-sgdqhtns 190 16 global global JJ cord-320959-sgdqhtns 190 17 20 20 CD cord-320959-sgdqhtns 190 18 population population NN cord-320959-sgdqhtns 190 19 . . . cord-320959-sgdqhtns 191 1 As as IN cord-320959-sgdqhtns 191 2 pathophysiologists pathophysiologist NNS cord-320959-sgdqhtns 191 3 , , , cord-320959-sgdqhtns 191 4 we -PRON- PRP cord-320959-sgdqhtns 191 5 have have VBP cord-320959-sgdqhtns 191 6 a a DT cord-320959-sgdqhtns 191 7 duty duty NN cord-320959-sgdqhtns 191 8 to to TO cord-320959-sgdqhtns 191 9 decipher decipher VB cord-320959-sgdqhtns 191 10 the the DT cord-320959-sgdqhtns 191 11 pathophysiology pathophysiology NN cord-320959-sgdqhtns 191 12 of of IN cord-320959-sgdqhtns 191 13 EVALI EVALI NNS cord-320959-sgdqhtns 191 14 for for IN cord-320959-sgdqhtns 191 15 the the DT cord-320959-sgdqhtns 191 16 good good NN cord-320959-sgdqhtns 191 17 of of IN cord-320959-sgdqhtns 191 18 all all DT cord-320959-sgdqhtns 191 19 patients patient NNS cord-320959-sgdqhtns 191 20 suffering suffer VBG cord-320959-sgdqhtns 191 21 from from IN cord-320959-sgdqhtns 191 22 the the DT cord-320959-sgdqhtns 191 23 disease disease NN cord-320959-sgdqhtns 191 24 , , , cord-320959-sgdqhtns 191 25 especially especially RB cord-320959-sgdqhtns 191 26 after after IN cord-320959-sgdqhtns 191 27 the the DT cord-320959-sgdqhtns 191 28 recent recent JJ cord-320959-sgdqhtns 191 29 identification identification NN cord-320959-sgdqhtns 191 30 of of IN cord-320959-sgdqhtns 191 31 the the DT cord-320959-sgdqhtns 191 32 widely widely RB cord-320959-sgdqhtns 191 33 utilized utilize VBN cord-320959-sgdqhtns 191 34 derivative derivative NN cord-320959-sgdqhtns 191 35 of of IN cord-320959-sgdqhtns 191 36 the the DT cord-320959-sgdqhtns 191 37 vitamin vitamin NN cord-320959-sgdqhtns 191 38 as as IN cord-320959-sgdqhtns 191 39 one one CD cord-320959-sgdqhtns 191 40 of of IN cord-320959-sgdqhtns 191 41 the the DT cord-320959-sgdqhtns 191 42 causal causal JJ cord-320959-sgdqhtns 191 43 agents agent NNS cord-320959-sgdqhtns 191 44 for for IN cord-320959-sgdqhtns 191 45 the the DT cord-320959-sgdqhtns 191 46 new new JJ cord-320959-sgdqhtns 191 47 catastrophic catastrophic JJ cord-320959-sgdqhtns 191 48 pulmonary pulmonary JJ cord-320959-sgdqhtns 191 49 disease disease NN cord-320959-sgdqhtns 191 50 . . . cord-320959-sgdqhtns 192 1 that that IN cord-320959-sgdqhtns 192 2 Vitamin vitamin NN cord-320959-sgdqhtns 192 3 E e NN cord-320959-sgdqhtns 192 4 acetate acetate NN cord-320959-sgdqhtns 192 5 may may MD cord-320959-sgdqhtns 192 6 facilitate facilitate VB cord-320959-sgdqhtns 192 7 gel gel NN cord-320959-sgdqhtns 192 8 - - HYPH cord-320959-sgdqhtns 192 9 liquid liquid NN cord-320959-sgdqhtns 192 10 crystalline crystalline NN cord-320959-sgdqhtns 192 11 phase phase NN cord-320959-sgdqhtns 192 12 transition transition NN cord-320959-sgdqhtns 192 13 to to TO cord-320959-sgdqhtns 192 14 confer confer VB cord-320959-sgdqhtns 192 15 acute acute JJ cord-320959-sgdqhtns 192 16 5 5 CD cord-320959-sgdqhtns 192 17 respiratory respiratory JJ cord-320959-sgdqhtns 192 18 distress distress NN cord-320959-sgdqhtns 192 19 [ [ -LRB- cord-320959-sgdqhtns 192 20 12 12 CD cord-320959-sgdqhtns 192 21 ] ] -RRB- cord-320959-sgdqhtns 192 22 . . . cord-320959-sgdqhtns 193 1 In in IN cord-320959-sgdqhtns 193 2 this this DT cord-320959-sgdqhtns 193 3 picture picture NN cord-320959-sgdqhtns 193 4 , , , cord-320959-sgdqhtns 193 5 Vitamin vitamin NN cord-320959-sgdqhtns 193 6 E e NN cord-320959-sgdqhtns 193 7 acetate acetate NN cord-320959-sgdqhtns 193 8 perturbs perturb VBZ cord-320959-sgdqhtns 193 9 the the DT cord-320959-sgdqhtns 193 10 packing packing NN cord-320959-sgdqhtns 193 11 of of IN cord-320959-sgdqhtns 193 12 phospholipids phospholipid NNS cord-320959-sgdqhtns 193 13 within within IN cord-320959-sgdqhtns 193 14 the the DT cord-320959-sgdqhtns 193 15 lipid lipid NN cord-320959-sgdqhtns 193 16 bilayer bilayer NN cord-320959-sgdqhtns 193 17 such such JJ cord-320959-sgdqhtns 193 18 that that IN cord-320959-sgdqhtns 193 19 the the DT cord-320959-sgdqhtns 193 20 system system NN cord-320959-sgdqhtns 193 21 thermodynamically thermodynamically RB cord-320959-sgdqhtns 193 22 prefers prefer VBZ cord-320959-sgdqhtns 193 23 the the DT cord-320959-sgdqhtns 193 24 liquid liquid JJ cord-320959-sgdqhtns 193 25 crystalline crystalline NN cord-320959-sgdqhtns 193 26 phase phase NN cord-320959-sgdqhtns 193 27 over over IN cord-320959-sgdqhtns 193 28 the the DT cord-320959-sgdqhtns 193 29 gel gel NN cord-320959-sgdqhtns 193 30 phase phase NN cord-320959-sgdqhtns 193 31 . . . cord-320959-sgdqhtns 194 1 However however RB cord-320959-sgdqhtns 194 2 , , , cord-320959-sgdqhtns 194 3 cholesterol cholesterol NN cord-320959-sgdqhtns 194 4 , , , cord-320959-sgdqhtns 194 5 which which WDT cord-320959-sgdqhtns 194 6 exists exist VBZ cord-320959-sgdqhtns 194 7 in in IN cord-320959-sgdqhtns 194 8 large large JJ cord-320959-sgdqhtns 194 9 excess excess NN cord-320959-sgdqhtns 194 10 to to IN cord-320959-sgdqhtns 194 11 Vitamin vitamin NN cord-320959-sgdqhtns 194 12 E e NN cord-320959-sgdqhtns 194 13 acetate acetate NN cord-320959-sgdqhtns 194 14 in in IN cord-320959-sgdqhtns 194 15 the the DT cord-320959-sgdqhtns 194 16 biological biological JJ cord-320959-sgdqhtns 194 17 membrane membrane NN cord-320959-sgdqhtns 194 18 , , , cord-320959-sgdqhtns 194 19 not not RB cord-320959-sgdqhtns 194 20 only only RB cord-320959-sgdqhtns 194 21 exerts exert VBZ cord-320959-sgdqhtns 194 22 similar similar JJ cord-320959-sgdqhtns 194 23 effect effect NN cord-320959-sgdqhtns 194 24 in in IN cord-320959-sgdqhtns 194 25 model model NN cord-320959-sgdqhtns 194 26 saturated saturate VBN cord-320959-sgdqhtns 194 27 phospholipid phospholipid NN cord-320959-sgdqhtns 194 28 bilayers bilayer NNS cord-320959-sgdqhtns 194 29 , , , cord-320959-sgdqhtns 194 30 but but CC cord-320959-sgdqhtns 194 31 also also RB cord-320959-sgdqhtns 194 32 reportedly reportedly RB cord-320959-sgdqhtns 194 33 abolishes abolish VBZ cord-320959-sgdqhtns 194 34 gel gel NN cord-320959-sgdqhtns 194 35 - - HYPH cord-320959-sgdqhtns 194 36 liquid liquid NN cord-320959-sgdqhtns 194 37 crystalline crystalline NN cord-320959-sgdqhtns 194 38 phase phase NN cord-320959-sgdqhtns 194 39 transition transition NN cord-320959-sgdqhtns 194 40 [ [ -LRB- cord-320959-sgdqhtns 194 41 38 38 CD cord-320959-sgdqhtns 194 42 ] ] -RRB- cord-320959-sgdqhtns 194 43 . . . cord-320959-sgdqhtns 195 1 Therefore therefore RB cord-320959-sgdqhtns 195 2 , , , cord-320959-sgdqhtns 195 3 gel-10 gel-10 NNP cord-320959-sgdqhtns 195 4 liquid liquid JJ cord-320959-sgdqhtns 195 5 crystalline crystalline NN cord-320959-sgdqhtns 195 6 phase phase NN cord-320959-sgdqhtns 195 7 transition transition NN cord-320959-sgdqhtns 195 8 may may MD cord-320959-sgdqhtns 195 9 be be VB cord-320959-sgdqhtns 195 10 irrelevant irrelevant JJ cord-320959-sgdqhtns 195 11 in in IN cord-320959-sgdqhtns 195 12 the the DT cord-320959-sgdqhtns 195 13 pathogenesis pathogenesis NN cord-320959-sgdqhtns 195 14 of of IN cord-320959-sgdqhtns 195 15 EVALI EVALI NNS cord-320959-sgdqhtns 195 16 . . . cord-320959-sgdqhtns 196 1 Reduced reduce VBN cord-320959-sgdqhtns 196 2 line line NN cord-320959-sgdqhtns 196 3 tension tension NN cord-320959-sgdqhtns 196 4 within within IN cord-320959-sgdqhtns 196 5 the the DT cord-320959-sgdqhtns 196 6 two two CD cord-320959-sgdqhtns 196 7 - - HYPH cord-320959-sgdqhtns 196 8 dimensional dimensional JJ cord-320959-sgdqhtns 196 9 phase phase NN cord-320959-sgdqhtns 196 10 boundary boundary NN cord-320959-sgdqhtns 196 11 confers confer VBZ cord-320959-sgdqhtns 196 12 smaller small JJR cord-320959-sgdqhtns 196 13 microdomains microdomain NNS cord-320959-sgdqhtns 196 14 5 5 CD cord-320959-sgdqhtns 196 15 and and CC cord-320959-sgdqhtns 196 16 decreases decrease VBZ cord-320959-sgdqhtns 196 17 the the DT cord-320959-sgdqhtns 196 18 free free JJ cord-320959-sgdqhtns 196 19 area area NN cord-320959-sgdqhtns 196 20 of of IN cord-320959-sgdqhtns 196 21 lipids lipid NNS cord-320959-sgdqhtns 196 22 [ [ -LRB- cord-320959-sgdqhtns 196 23 87 87 CD cord-320959-sgdqhtns 196 24 ] ] -RRB- cord-320959-sgdqhtns 196 25 . . . cord-320959-sgdqhtns 197 1 As as IN cord-320959-sgdqhtns 197 2 a a DT cord-320959-sgdqhtns 197 3 result result NN cord-320959-sgdqhtns 197 4 , , , cord-320959-sgdqhtns 197 5 the the DT cord-320959-sgdqhtns 197 6 surface surface NN cord-320959-sgdqhtns 197 7 viscosity viscosity NN cord-320959-sgdqhtns 197 8 of of IN cord-320959-sgdqhtns 197 9 pulmonary pulmonary JJ cord-320959-sgdqhtns 197 10 surfactants surfactant NNS cord-320959-sgdqhtns 197 11 exponentially exponentially RB cord-320959-sgdqhtns 197 12 increases increase VBZ cord-320959-sgdqhtns 197 13 to to TO cord-320959-sgdqhtns 197 14 perturb perturb VB cord-320959-sgdqhtns 197 15 the the DT cord-320959-sgdqhtns 197 16 dynamics dynamic NNS cord-320959-sgdqhtns 197 17 of of IN cord-320959-sgdqhtns 197 18 respiratory respiratory JJ cord-320959-sgdqhtns 197 19 compressionexpansion compressionexpansion NN cord-320959-sgdqhtns 197 20 cycling cycling NN cord-320959-sgdqhtns 197 21 , , , cord-320959-sgdqhtns 197 22 causing cause VBG cord-320959-sgdqhtns 197 23 acute acute JJ cord-320959-sgdqhtns 197 24 respiratory respiratory JJ cord-320959-sgdqhtns 197 25 distress distress NN cord-320959-sgdqhtns 197 26 analogous analogous JJ cord-320959-sgdqhtns 197 27 to to IN cord-320959-sgdqhtns 197 28 those those DT cord-320959-sgdqhtns 197 29 seen see VBN cord-320959-sgdqhtns 197 30 in in IN cord-320959-sgdqhtns 197 31 patients patient NNS cord-320959-sgdqhtns 197 32 with with IN cord-320959-sgdqhtns 197 33 EVALI EVALI NNS cord-320959-sgdqhtns 197 34 . . . cord-320959-sgdqhtns 197 35 _SP cord-320959-sgdqhtns 198 1 Update update NN cord-320959-sgdqhtns 198 2 : : : cord-320959-sgdqhtns 198 3 Characteristics characteristic NNS cord-320959-sgdqhtns 198 4 of of IN cord-320959-sgdqhtns 198 5 a a DT cord-320959-sgdqhtns 198 6 Nationwide Nationwide NNP cord-320959-sgdqhtns 198 7 Outbreak outbreak NN cord-320959-sgdqhtns 198 8 of of IN cord-320959-sgdqhtns 198 9 E e NN cord-320959-sgdqhtns 198 10 - - NN cord-320959-sgdqhtns 198 11 cigarette cigarette NN cord-320959-sgdqhtns 198 12 , , , cord-320959-sgdqhtns 198 13 or or CC cord-320959-sgdqhtns 198 14 Vaping vaping NN cord-320959-sgdqhtns 198 15 , , , cord-320959-sgdqhtns 198 16 Product Product NNP cord-320959-sgdqhtns 198 17 Use use NN cord-320959-sgdqhtns 198 18 - - HYPH cord-320959-sgdqhtns 198 19 Associated Associated NNP cord-320959-sgdqhtns 198 20 Lung Lung NNP cord-320959-sgdqhtns 198 21 Injury injury NN cord-320959-sgdqhtns 199 1 -United -unite VBN cord-320959-sgdqhtns 199 2 States state NNS cord-320959-sgdqhtns 200 1 Pulmonary Pulmonary NNP cord-320959-sgdqhtns 200 2 Illness Illness NNP cord-320959-sgdqhtns 201 1 Related relate VBN cord-320959-sgdqhtns 201 2 to to IN cord-320959-sgdqhtns 201 3 E e NN cord-320959-sgdqhtns 201 4 - - NN cord-320959-sgdqhtns 201 5 Cigarette cigarette NN cord-320959-sgdqhtns 201 6 Use Use NNP cord-320959-sgdqhtns 201 7 in in IN cord-320959-sgdqhtns 201 8 Illinois Illinois NNP cord-320959-sgdqhtns 201 9 and and CC cord-320959-sgdqhtns 201 10 Wisconsin Wisconsin NNP cord-320959-sgdqhtns 202 1 -Final -Final : cord-320959-sgdqhtns 202 2 Report Report NNP cord-320959-sgdqhtns 202 3 Update Update NNP cord-320959-sgdqhtns 202 4 : : : cord-320959-sgdqhtns 203 1 Interim Interim NNP cord-320959-sgdqhtns 203 2 Guidance Guidance NNP cord-320959-sgdqhtns 203 3 for for IN cord-320959-sgdqhtns 203 4 Health Health NNP cord-320959-sgdqhtns 203 5 Care Care NNP cord-320959-sgdqhtns 203 6 Providers Providers NNPS cord-320959-sgdqhtns 203 7 Evaluating evaluate VBG cord-320959-sgdqhtns 203 8 and and CC cord-320959-sgdqhtns 203 9 Caring care VBG cord-320959-sgdqhtns 203 10 for for IN cord-320959-sgdqhtns 203 11 Patients patient NNS cord-320959-sgdqhtns 203 12 with with IN cord-320959-sgdqhtns 203 13 Suspected suspected JJ cord-320959-sgdqhtns 203 14 E e NN cord-320959-sgdqhtns 203 15 - - NN cord-320959-sgdqhtns 203 16 cigarette cigarette NN cord-320959-sgdqhtns 203 17 , , , cord-320959-sgdqhtns 203 18 or or CC cord-320959-sgdqhtns 203 19 Vaping vaping NN cord-320959-sgdqhtns 203 20 , , , cord-320959-sgdqhtns 203 21 Product product NN cord-320959-sgdqhtns 203 22 Use use NN cord-320959-sgdqhtns 203 23 Associated Associated NNP cord-320959-sgdqhtns 203 24 Lung Lung NNP cord-320959-sgdqhtns 203 25 Injury injury NN cord-320959-sgdqhtns 204 1 -United -unite VBN cord-320959-sgdqhtns 204 2 States state NNS cord-320959-sgdqhtns 205 1 Imaging imaging NN cord-320959-sgdqhtns 205 2 of of IN cord-320959-sgdqhtns 205 3 vaping vaping NN cord-320959-sgdqhtns 205 4 - - HYPH cord-320959-sgdqhtns 205 5 associated associate VBN cord-320959-sgdqhtns 205 6 lung lung NN cord-320959-sgdqhtns 205 7 disease disease NN cord-320959-sgdqhtns 206 1 Syndromic syndromic JJ cord-320959-sgdqhtns 206 2 surveillance surveillance NN cord-320959-sgdqhtns 206 3 for for IN cord-320959-sgdqhtns 206 4 e e NN cord-320959-sgdqhtns 206 5 - - NN cord-320959-sgdqhtns 206 6 cigarette cigarette NN cord-320959-sgdqhtns 206 7 , , , cord-320959-sgdqhtns 206 8 or or CC cord-320959-sgdqhtns 206 9 vaping vaping NN cord-320959-sgdqhtns 206 10 , , , cord-320959-sgdqhtns 206 11 product product NN cord-320959-sgdqhtns 206 12 use use NN cord-320959-sgdqhtns 206 13 - - HYPH cord-320959-sgdqhtns 206 14 associated associate VBN cord-320959-sgdqhtns 206 15 lung lung NN cord-320959-sgdqhtns 206 16 injury injury NN cord-320959-sgdqhtns 206 17 Tolerance tolerance NN cord-320959-sgdqhtns 206 18 to to IN cord-320959-sgdqhtns 206 19 hypothermic hypothermic JJ cord-320959-sgdqhtns 206 20 and and CC cord-320959-sgdqhtns 206 21 antinoceptive antinoceptive JJ cord-320959-sgdqhtns 206 22 effects effect NNS cord-320959-sgdqhtns 206 23 of of IN cord-320959-sgdqhtns 206 24 ∆9-tetrahydrocannabinol ∆9-tetrahydrocannabinol NN cord-320959-sgdqhtns 206 25 ( ( -LRB- cord-320959-sgdqhtns 206 26 THC THC NNP cord-320959-sgdqhtns 206 27 ) ) -RRB- cord-320959-sgdqhtns 206 28 vapor vapor NN cord-320959-sgdqhtns 206 29 inhalation inhalation NN cord-320959-sgdqhtns 206 30 in in IN cord-320959-sgdqhtns 206 31 rats rat NNS cord-320959-sgdqhtns 207 1 Lasting last VBG cord-320959-sgdqhtns 207 2 effects effect NNS cord-320959-sgdqhtns 207 3 of of IN cord-320959-sgdqhtns 207 4 repeated repeat VBN cord-320959-sgdqhtns 207 5 ∆9-tetrahydrocannabinol ∆9-tetrahydrocannabinol NN cord-320959-sgdqhtns 207 6 vapour vapour NN cord-320959-sgdqhtns 207 7 inhalation inhalation NN cord-320959-sgdqhtns 207 8 during during IN cord-320959-sgdqhtns 207 9 adolescence adolescence NN cord-320959-sgdqhtns 207 10 in in IN cord-320959-sgdqhtns 207 11 male male JJ cord-320959-sgdqhtns 207 12 and and CC cord-320959-sgdqhtns 207 13 female female JJ cord-320959-sgdqhtns 207 14 rats rat NNS cord-320959-sgdqhtns 207 15 tree tree NN cord-320959-sgdqhtns 207 16 - - HYPH cord-320959-sgdqhtns 207 17 in in IN cord-320959-sgdqhtns 207 18 - - HYPH cord-320959-sgdqhtns 207 19 bloom bloom NN cord-320959-sgdqhtns 207 20 " " '' cord-320959-sgdqhtns 207 21 : : : cord-320959-sgdqhtns 207 22 Severe severe JJ cord-320959-sgdqhtns 207 23 acute acute JJ cord-320959-sgdqhtns 207 24 lung lung NN cord-320959-sgdqhtns 207 25 injury injury NN cord-320959-sgdqhtns 207 26 induced induce VBN cord-320959-sgdqhtns 207 27 by by IN cord-320959-sgdqhtns 207 28 vaping vape VBG cord-320959-sgdqhtns 207 29 cannabis cannabis NN cord-320959-sgdqhtns 207 30 oil oil NN cord-320959-sgdqhtns 207 31 Pathology Pathology NNP cord-320959-sgdqhtns 207 32 of of IN cord-320959-sgdqhtns 207 33 vaping vaping NN cord-320959-sgdqhtns 207 34 - - HYPH cord-320959-sgdqhtns 207 35 associated associate VBN cord-320959-sgdqhtns 207 36 lung lung NN cord-320959-sgdqhtns 207 37 injury injury NN cord-320959-sgdqhtns 207 38 More more RBR cord-320959-sgdqhtns 207 39 on on IN cord-320959-sgdqhtns 207 40 the the DT cord-320959-sgdqhtns 207 41 Pathology Pathology NNP cord-320959-sgdqhtns 207 42 of of IN cord-320959-sgdqhtns 207 43 Vaping Vaping NNP cord-320959-sgdqhtns 207 44 - - HYPH cord-320959-sgdqhtns 207 45 Associated Associated NNP cord-320959-sgdqhtns 207 46 Lung Lung NNP cord-320959-sgdqhtns 207 47 Injury Injury NNP cord-320959-sgdqhtns 207 48 Pulmonary pulmonary JJ cord-320959-sgdqhtns 207 49 lipid lipid NN cord-320959-sgdqhtns 207 50 - - HYPH cord-320959-sgdqhtns 207 51 laden laden NN cord-320959-sgdqhtns 207 52 macrophages macrophage NNS cord-320959-sgdqhtns 207 53 and and CC cord-320959-sgdqhtns 208 1 5 5 LS cord-320959-sgdqhtns 208 2 vaping vape VBG cord-320959-sgdqhtns 208 3 Vitamin vitamin NN cord-320959-sgdqhtns 208 4 E e NN cord-320959-sgdqhtns 208 5 acetate acetate NN cord-320959-sgdqhtns 208 6 in in IN cord-320959-sgdqhtns 208 7 bronchoalveolarlavage bronchoalveolarlavage NN cord-320959-sgdqhtns 208 8 fluid fluid NN cord-320959-sgdqhtns 208 9 associated associate VBN cord-320959-sgdqhtns 208 10 with with IN cord-320959-sgdqhtns 208 11 EVALI EVALI NNS cord-320959-sgdqhtns 208 12 A a DT cord-320959-sgdqhtns 208 13 history history NN cord-320959-sgdqhtns 208 14 of of IN cord-320959-sgdqhtns 208 15 vitamin vitamin NN cord-320959-sgdqhtns 208 16 e e NN cord-320959-sgdqhtns 208 17 Vitamin vitamin NN cord-320959-sgdqhtns 208 18 E e NN cord-320959-sgdqhtns 208 19 , , , cord-320959-sgdqhtns 208 20 antioxidant antioxidant NN cord-320959-sgdqhtns 208 21 and and CC cord-320959-sgdqhtns 208 22 nothing nothing NN cord-320959-sgdqhtns 208 23 more more JJR cord-320959-sgdqhtns 208 24 Affinity Affinity NNP cord-320959-sgdqhtns 208 25 for for IN cord-320959-sgdqhtns 208 26 α α NN cord-320959-sgdqhtns 208 27 - - HYPH cord-320959-sgdqhtns 208 28 tocopherol tocopherol NN cord-320959-sgdqhtns 208 29 transfer transfer NN cord-320959-sgdqhtns 208 30 protein protein NN cord-320959-sgdqhtns 208 31 as as IN cord-320959-sgdqhtns 208 32 a a DT cord-320959-sgdqhtns 208 33 determinant determinant NN cord-320959-sgdqhtns 208 34 of of IN cord-320959-sgdqhtns 208 35 the the DT cord-320959-sgdqhtns 208 36 biological biological JJ cord-320959-sgdqhtns 208 37 activities activity NNS cord-320959-sgdqhtns 208 38 of of IN cord-320959-sgdqhtns 208 39 vitamin vitamin NN cord-320959-sgdqhtns 208 40 E e NN cord-320959-sgdqhtns 208 41 analogs analog NNS cord-320959-sgdqhtns 209 1 The the DT cord-320959-sgdqhtns 209 2 molecular molecular JJ cord-320959-sgdqhtns 209 3 basis basis NN cord-320959-sgdqhtns 209 4 of of IN cord-320959-sgdqhtns 209 5 vitamin vitamin NN cord-320959-sgdqhtns 209 6 E e NN cord-320959-sgdqhtns 209 7 retention retention NN cord-320959-sgdqhtns 209 8 : : : cord-320959-sgdqhtns 210 1 Structure structure NN cord-320959-sgdqhtns 210 2 of of IN cord-320959-sgdqhtns 210 3 human human JJ cord-320959-sgdqhtns 210 4 α α NN cord-320959-sgdqhtns 210 5 - - HYPH cord-320959-sgdqhtns 210 6 tocopherol tocopherol NN cord-320959-sgdqhtns 210 7 transfer transfer NN cord-320959-sgdqhtns 210 8 protein protein NN cord-320959-sgdqhtns 210 9 α α NN cord-320959-sgdqhtns 210 10 - - HYPH cord-320959-sgdqhtns 210 11 Tocopherol tocopherol NN cord-320959-sgdqhtns 210 12 transfer transfer NN cord-320959-sgdqhtns 210 13 protein protein NN cord-320959-sgdqhtns 210 14 stimulates stimulate VBZ cord-320959-sgdqhtns 210 15 the the DT cord-320959-sgdqhtns 210 16 secretion secretion NN cord-320959-sgdqhtns 210 17 of of IN cord-320959-sgdqhtns 210 18 α α NN cord-320959-sgdqhtns 210 19 - - HYPH cord-320959-sgdqhtns 210 20 tocopherol tocopherol NN cord-320959-sgdqhtns 210 21 from from IN cord-320959-sgdqhtns 210 22 a a DT cord-320959-sgdqhtns 210 23 cultured cultured JJ cord-320959-sgdqhtns 210 24 liver liver NN cord-320959-sgdqhtns 210 25 cell cell NN cord-320959-sgdqhtns 210 26 line line NN cord-320959-sgdqhtns 210 27 through through IN cord-320959-sgdqhtns 210 28 a a DT cord-320959-sgdqhtns 210 29 brefeldin brefeldin NNP cord-320959-sgdqhtns 210 30 A A NNP cord-320959-sgdqhtns 210 31 - - HYPH cord-320959-sgdqhtns 210 32 insensitive insensitive JJ cord-320959-sgdqhtns 210 33 pathway pathway NN cord-320959-sgdqhtns 211 1 α α NN cord-320959-sgdqhtns 211 2 - - HYPH cord-320959-sgdqhtns 211 3 Tocopherol tocopherol NN cord-320959-sgdqhtns 211 4 transfer transfer NN cord-320959-sgdqhtns 211 5 protein protein NN cord-320959-sgdqhtns 211 6 mediates mediate VBZ cord-320959-sgdqhtns 211 7 20 20 CD cord-320959-sgdqhtns 211 8 protective protective JJ cord-320959-sgdqhtns 211 9 hypercapnia hypercapnia NN cord-320959-sgdqhtns 211 10 in in IN cord-320959-sgdqhtns 211 11 murine murine JJ cord-320959-sgdqhtns 211 12 ventilator ventilator NN cord-320959-sgdqhtns 211 13 - - HYPH cord-320959-sgdqhtns 211 14 induced induce VBN cord-320959-sgdqhtns 211 15 lung lung NN cord-320959-sgdqhtns 211 16 injury injury NN cord-320959-sgdqhtns 211 17 Safety Safety NNP cord-320959-sgdqhtns 211 18 assessment assessment NN cord-320959-sgdqhtns 211 19 of of IN cord-320959-sgdqhtns 211 20 the the DT cord-320959-sgdqhtns 211 21 substance substance NN cord-320959-sgdqhtns 211 22 α α NN cord-320959-sgdqhtns 211 23 - - HYPH cord-320959-sgdqhtns 211 24 tocopherol tocopherol NN cord-320959-sgdqhtns 211 25 acetate acetate NN cord-320959-sgdqhtns 211 26 for for IN cord-320959-sgdqhtns 211 27 use use NN cord-320959-sgdqhtns 211 28 in in IN cord-320959-sgdqhtns 211 29 food food NN cord-320959-sgdqhtns 211 30 contact contact NN cord-320959-sgdqhtns 211 31 materials material NNS cord-320959-sgdqhtns 212 1 All all DT cord-320959-sgdqhtns 212 2 - - HYPH cord-320959-sgdqhtns 212 3 rac rac NN cord-320959-sgdqhtns 212 4 - - HYPH cord-320959-sgdqhtns 212 5 α α NN cord-320959-sgdqhtns 212 6 - - HYPH cord-320959-sgdqhtns 212 7 Tocopherol tocopherol NN cord-320959-sgdqhtns 212 8 Acetate Acetate NNP cord-320959-sgdqhtns 212 9 Is be VBZ cord-320959-sgdqhtns 212 10 a a DT cord-320959-sgdqhtns 212 11 Better well JJR cord-320959-sgdqhtns 212 12 Vitamin vitamin NN cord-320959-sgdqhtns 212 13 E e NN cord-320959-sgdqhtns 212 14 Source source NN cord-320959-sgdqhtns 212 15 than than IN cord-320959-sgdqhtns 212 16 all all DT cord-320959-sgdqhtns 212 17 - - HYPH cord-320959-sgdqhtns 212 18 rac rac NN cord-320959-sgdqhtns 212 19 - - HYPH cord-320959-sgdqhtns 212 20 α α NN cord-320959-sgdqhtns 212 21 - - HYPH cord-320959-sgdqhtns 212 22 Tocopherol tocopherol NN cord-320959-sgdqhtns 212 23 Succinate Succinate NNP cord-320959-sgdqhtns 212 24 for for IN cord-320959-sgdqhtns 212 25 Broilers broiler NNS cord-320959-sgdqhtns 213 1 The the DT cord-320959-sgdqhtns 213 2 distribution distribution NN cord-320959-sgdqhtns 213 3 and and CC cord-320959-sgdqhtns 213 4 relative relative JJ cord-320959-sgdqhtns 213 5 hydrolysis hydrolysis NN cord-320959-sgdqhtns 213 6 of of IN cord-320959-sgdqhtns 213 7 tocopheryl tocopheryl NN cord-320959-sgdqhtns 213 8 acetate acetate NN cord-320959-sgdqhtns 213 9 in in IN cord-320959-sgdqhtns 213 10 the the DT cord-320959-sgdqhtns 213 11 different different JJ cord-320959-sgdqhtns 213 12 matrices matrix NNS cord-320959-sgdqhtns 213 13 coexisting coexist VBG cord-320959-sgdqhtns 213 14 in in IN cord-320959-sgdqhtns 213 15 the the DT cord-320959-sgdqhtns 213 16 lumen lumen NN cord-320959-sgdqhtns 213 17 of of IN cord-320959-sgdqhtns 213 18 the the DT cord-320959-sgdqhtns 213 19 5 5 CD cord-320959-sgdqhtns 213 20 small small JJ cord-320959-sgdqhtns 213 21 intestine intestine NN cord-320959-sgdqhtns 213 22 during during IN cord-320959-sgdqhtns 213 23 digestion digestion NN cord-320959-sgdqhtns 213 24 could could MD cord-320959-sgdqhtns 213 25 explain explain VB cord-320959-sgdqhtns 213 26 its -PRON- PRP$ cord-320959-sgdqhtns 213 27 low low JJ cord-320959-sgdqhtns 213 28 bioavailability bioavailability NN cord-320959-sgdqhtns 213 29 Supercritical supercritical JJ cord-320959-sgdqhtns 213 30 fluid fluid NN cord-320959-sgdqhtns 213 31 - - HYPH cord-320959-sgdqhtns 213 32 aerosolized aerosolize VBN cord-320959-sgdqhtns 213 33 vitamin vitamin NN cord-320959-sgdqhtns 213 34 E e NN cord-320959-sgdqhtns 213 35 pretreatment pretreatment NN cord-320959-sgdqhtns 213 36 decreases decrease VBZ cord-320959-sgdqhtns 213 37 leak leak NN cord-320959-sgdqhtns 213 38 in in IN cord-320959-sgdqhtns 213 39 isolated isolate VBN cord-320959-sgdqhtns 213 40 oxidant oxidant NN cord-320959-sgdqhtns 213 41 - - HYPH cord-320959-sgdqhtns 213 42 perfused perfuse VBN cord-320959-sgdqhtns 213 43 rat rat NN cord-320959-sgdqhtns 213 44 lungs lung NNS cord-320959-sgdqhtns 214 1 Aerosol aerosol NN cord-320959-sgdqhtns 214 2 - - HYPH cord-320959-sgdqhtns 214 3 administered administer VBN cord-320959-sgdqhtns 214 4 α α NN cord-320959-sgdqhtns 214 5 - - HYPH cord-320959-sgdqhtns 214 6 tocopherol tocopherol NN cord-320959-sgdqhtns 214 7 attenuates attenuate VBZ cord-320959-sgdqhtns 214 8 lung lung NN cord-320959-sgdqhtns 214 9 inflammation inflammation NN cord-320959-sgdqhtns 214 10 in in IN cord-320959-sgdqhtns 214 11 rats rat NNS cord-320959-sgdqhtns 214 12 given give VBN cord-320959-sgdqhtns 214 13 lipopolysaccharide lipopolysaccharide NN cord-320959-sgdqhtns 214 14 intratracheally intratracheally RB cord-320959-sgdqhtns 214 15 Hydrolysis Hydrolysis NNP cord-320959-sgdqhtns 214 16 of of IN cord-320959-sgdqhtns 214 17 RRR RRR NNP cord-320959-sgdqhtns 214 18 - - HYPH cord-320959-sgdqhtns 214 19 αtocopheryl αtocopheryl NNP cord-320959-sgdqhtns 214 20 acetate acetate NN cord-320959-sgdqhtns 215 1 ( ( -LRB- cord-320959-sgdqhtns 215 2 vitamin vitamin NN cord-320959-sgdqhtns 215 3 E e NN cord-320959-sgdqhtns 215 4 acetate acetate NN cord-320959-sgdqhtns 215 5 ) ) -RRB- cord-320959-sgdqhtns 216 1 in in IN cord-320959-sgdqhtns 216 2 the the DT cord-320959-sgdqhtns 216 3 skin skin NN cord-320959-sgdqhtns 216 4 and and CC cord-320959-sgdqhtns 216 5 its -PRON- PRP$ cord-320959-sgdqhtns 216 6 UV uv NN cord-320959-sgdqhtns 216 7 protecting protect VBG cord-320959-sgdqhtns 216 8 activity activity NN cord-320959-sgdqhtns 216 9 ( ( -LRB- cord-320959-sgdqhtns 216 10 an an DT cord-320959-sgdqhtns 216 11 in in IN cord-320959-sgdqhtns 216 12 vivo vivo NNP cord-320959-sgdqhtns 216 13 15 15 CD cord-320959-sgdqhtns 216 14 study study NN cord-320959-sgdqhtns 216 15 with with IN cord-320959-sgdqhtns 216 16 the the DT cord-320959-sgdqhtns 216 17 rat rat NN cord-320959-sgdqhtns 216 18 ) ) -RRB- cord-320959-sgdqhtns 216 19 Characterization characterization NN cord-320959-sgdqhtns 216 20 of of IN cord-320959-sgdqhtns 216 21 antioxidant antioxidant JJ cord-320959-sgdqhtns 216 22 activities activity NNS cord-320959-sgdqhtns 216 23 of of IN cord-320959-sgdqhtns 216 24 pulmonary pulmonary JJ cord-320959-sgdqhtns 216 25 surfactant surfactant NN cord-320959-sgdqhtns 216 26 mixtures mixture NNS cord-320959-sgdqhtns 216 27 Type Type NNP cord-320959-sgdqhtns 216 28 II II NNP cord-320959-sgdqhtns 216 29 pneumocytes pneumocyte NNS cord-320959-sgdqhtns 216 30 secrete secrete VBP cord-320959-sgdqhtns 216 31 vitamin vitamin NN cord-320959-sgdqhtns 216 32 E e NN cord-320959-sgdqhtns 216 33 20 20 CD cord-320959-sgdqhtns 216 34 together together RB cord-320959-sgdqhtns 216 35 with with IN cord-320959-sgdqhtns 216 36 surfactant surfactant NN cord-320959-sgdqhtns 216 37 lipids lipid NNS cord-320959-sgdqhtns 216 38 Oxidative oxidative JJ cord-320959-sgdqhtns 216 39 stress stress NN cord-320959-sgdqhtns 216 40 and and CC cord-320959-sgdqhtns 216 41 antioxidants antioxidant NNS cord-320959-sgdqhtns 216 42 at at IN cord-320959-sgdqhtns 216 43 biosurfaces biosurface NNS cord-320959-sgdqhtns 216 44 : : : cord-320959-sgdqhtns 216 45 plants plant NNS cord-320959-sgdqhtns 216 46 , , , cord-320959-sgdqhtns 216 47 skin skin NN cord-320959-sgdqhtns 216 48 , , , cord-320959-sgdqhtns 216 49 and and CC cord-320959-sgdqhtns 216 50 respiratory respiratory JJ cord-320959-sgdqhtns 216 51 tract tract NN cord-320959-sgdqhtns 216 52 surfaces surface NNS cord-320959-sgdqhtns 216 53 Vitamin vitamin NN cord-320959-sgdqhtns 216 54 E e NN cord-320959-sgdqhtns 216 55 : : : cord-320959-sgdqhtns 216 56 Non non JJ cord-320959-sgdqhtns 216 57 - - JJ cord-320959-sgdqhtns 216 58 antioxidant antioxidant JJ cord-320959-sgdqhtns 216 59 roles role NNS cord-320959-sgdqhtns 217 1 The the DT cord-320959-sgdqhtns 217 2 rise rise NN cord-320959-sgdqhtns 217 3 , , , cord-320959-sgdqhtns 217 4 the the DT cord-320959-sgdqhtns 217 5 fall fall NN cord-320959-sgdqhtns 217 6 and and CC cord-320959-sgdqhtns 217 7 the the DT cord-320959-sgdqhtns 217 8 renaissance renaissance NN cord-320959-sgdqhtns 217 9 of of IN cord-320959-sgdqhtns 217 10 Vitamin vitamin NN cord-320959-sgdqhtns 217 11 E e NN cord-320959-sgdqhtns 217 12 Vitamin vitamin NN cord-320959-sgdqhtns 217 13 E e NN cord-320959-sgdqhtns 217 14 : : : cord-320959-sgdqhtns 217 15 Emerging emerge VBG cord-320959-sgdqhtns 217 16 aspects aspect NNS cord-320959-sgdqhtns 217 17 and and CC cord-320959-sgdqhtns 217 18 new new JJ cord-320959-sgdqhtns 217 19 directions direction NNS cord-320959-sgdqhtns 217 20 Potential Potential NNP cord-320959-sgdqhtns 217 21 for for IN cord-320959-sgdqhtns 217 22 release release NN cord-320959-sgdqhtns 217 23 of of IN cord-320959-sgdqhtns 217 24 pulmonary pulmonary JJ cord-320959-sgdqhtns 217 25 toxic toxic JJ cord-320959-sgdqhtns 217 26 ketene ketene NNP cord-320959-sgdqhtns 217 27 from from IN cord-320959-sgdqhtns 217 28 vaping vape VBG cord-320959-sgdqhtns 217 29 pyrolysis pyrolysis NN cord-320959-sgdqhtns 217 30 of of IN cord-320959-sgdqhtns 217 31 Vitamin vitamin NN cord-320959-sgdqhtns 217 32 E e NN cord-320959-sgdqhtns 217 33 acetate acetate NN cord-320959-sgdqhtns 217 34 Hydrogen Hydrogen NNP cord-320959-sgdqhtns 217 35 Bonding Bonding NNP cord-320959-sgdqhtns 217 36 between between IN cord-320959-sgdqhtns 217 37 Tetrahydrocannabinol tetrahydrocannabinol NN cord-320959-sgdqhtns 217 38 and and CC cord-320959-sgdqhtns 217 39 Vitamin vitamin NN cord-320959-sgdqhtns 217 40 E e NN cord-320959-sgdqhtns 217 41 Acetate acetate NN cord-320959-sgdqhtns 217 42 in in IN cord-320959-sgdqhtns 217 43 Unvaped Unvaped NNP cord-320959-sgdqhtns 217 44 , , , cord-320959-sgdqhtns 217 45 Aerosolized Aerosolized NNP cord-320959-sgdqhtns 217 46 , , , cord-320959-sgdqhtns 217 47 and and CC cord-320959-sgdqhtns 217 48 Condensed condense VBD cord-320959-sgdqhtns 217 49 10 10 CD cord-320959-sgdqhtns 217 50 Aerosol Aerosol NNP cord-320959-sgdqhtns 217 51 e e NN cord-320959-sgdqhtns 217 52 - - : cord-320959-sgdqhtns 217 53 Liquids Liquids NNP cord-320959-sgdqhtns 217 54 Interaction Interaction NNP cord-320959-sgdqhtns 217 55 of of IN cord-320959-sgdqhtns 217 56 vitamin vitamin NN cord-320959-sgdqhtns 217 57 E e NN cord-320959-sgdqhtns 217 58 with with IN cord-320959-sgdqhtns 217 59 saturated saturated JJ cord-320959-sgdqhtns 217 60 phospholipid phospholipid NN cord-320959-sgdqhtns 217 61 bilayers bilayer NNS cord-320959-sgdqhtns 217 62 Modulated modulate VBN cord-320959-sgdqhtns 217 63 phases phase NNS cord-320959-sgdqhtns 217 64 of of IN cord-320959-sgdqhtns 217 65 phospholipid phospholipid NN cord-320959-sgdqhtns 217 66 bilayers bilayer NNS cord-320959-sgdqhtns 217 67 induced induce VBN cord-320959-sgdqhtns 217 68 by by IN cord-320959-sgdqhtns 217 69 tocopherols tocopherol NNS cord-320959-sgdqhtns 217 70 Targeting target VBG cord-320959-sgdqhtns 217 71 cholesterol cholesterol NN cord-320959-sgdqhtns 217 72 homeostasis homeostasis NN cord-320959-sgdqhtns 217 73 in in IN cord-320959-sgdqhtns 217 74 lung lung NN cord-320959-sgdqhtns 217 75 diseases disease NNS cord-320959-sgdqhtns 218 1 A a DT cord-320959-sgdqhtns 218 2 Unique Unique NNP cord-320959-sgdqhtns 218 3 Case case NN cord-320959-sgdqhtns 218 4 of of IN cord-320959-sgdqhtns 218 5 Secondary Secondary NNP cord-320959-sgdqhtns 218 6 Pulmonary Pulmonary NNP cord-320959-sgdqhtns 218 7 Alveolar Alveolar NNP cord-320959-sgdqhtns 218 8 Proteinosis Proteinosis NNP cord-320959-sgdqhtns 219 1 Following follow VBG cord-320959-sgdqhtns 219 2 E e NN cord-320959-sgdqhtns 219 3 - - NN cord-320959-sgdqhtns 219 4 Cigarette cigarette NN cord-320959-sgdqhtns 219 5 , , , cord-320959-sgdqhtns 219 6 or or CC cord-320959-sgdqhtns 219 7 Vaping vaping NN cord-320959-sgdqhtns 219 8 , , , cord-320959-sgdqhtns 219 9 Product Product NNP cord-320959-sgdqhtns 219 10 Use use NN cord-320959-sgdqhtns 219 11 - - HYPH cord-320959-sgdqhtns 219 12 Associated Associated NNP cord-320959-sgdqhtns 219 13 Lung Lung NNP cord-320959-sgdqhtns 219 14 Injury injury NN cord-320959-sgdqhtns 219 15 ( ( -LRB- cord-320959-sgdqhtns 220 1 EVALI EVALI NNP cord-320959-sgdqhtns 220 2 ) ) -RRB- cord-320959-sgdqhtns 220 3 Studies study NNS cord-320959-sgdqhtns 220 4 on on IN cord-320959-sgdqhtns 220 5 lecithin lecithin NN cord-320959-sgdqhtns 220 6 - - HYPH cord-320959-sgdqhtns 220 7 cholesterol cholesterol NN cord-320959-sgdqhtns 220 8 - - HYPH cord-320959-sgdqhtns 220 9 water water NN cord-320959-sgdqhtns 220 10 interactions interaction NNS cord-320959-sgdqhtns 220 11 by by IN cord-320959-sgdqhtns 220 12 differential differential JJ cord-320959-sgdqhtns 220 13 scanning scanning NN cord-320959-sgdqhtns 220 14 calorimetry calorimetry NN cord-320959-sgdqhtns 220 15 and and CC cord-320959-sgdqhtns 221 1 X x NN cord-320959-sgdqhtns 221 2 - - NN cord-320959-sgdqhtns 221 3 ray ray NN cord-320959-sgdqhtns 221 4 diffraction diffraction NN cord-320959-sgdqhtns 221 5 Calorimetric Calorimetric NNP cord-320959-sgdqhtns 221 6 evidence evidence NN cord-320959-sgdqhtns 221 7 for for IN cord-320959-sgdqhtns 221 8 the the DT cord-320959-sgdqhtns 221 9 liquid liquid JJ cord-320959-sgdqhtns 221 10 - - HYPH cord-320959-sgdqhtns 221 11 crystalline crystalline NN cord-320959-sgdqhtns 221 12 state state NN cord-320959-sgdqhtns 221 13 of of IN cord-320959-sgdqhtns 221 14 lipids lipid NNS cord-320959-sgdqhtns 221 15 in in IN cord-320959-sgdqhtns 221 16 a a DT cord-320959-sgdqhtns 221 17 biomembrane biomembrane NNP cord-320959-sgdqhtns 221 18 Lipid lipid NN cord-320959-sgdqhtns 221 19 droplet droplet NN cord-320959-sgdqhtns 221 20 functions function NNS cord-320959-sgdqhtns 221 21 beyond beyond IN cord-320959-sgdqhtns 221 22 energy energy NN cord-320959-sgdqhtns 221 23 storage storage NN cord-320959-sgdqhtns 221 24 Nonalcoholic nonalcoholic JJ cord-320959-sgdqhtns 221 25 fatty fatty JJ cord-320959-sgdqhtns 221 26 liver liver NN cord-320959-sgdqhtns 221 27 disease disease NN cord-320959-sgdqhtns 221 28 impairs impair VBZ cord-320959-sgdqhtns 221 29 the the DT cord-320959-sgdqhtns 221 30 cytochrome cytochrome NN cord-320959-sgdqhtns 221 31 P-450-dependent p-450-dependent NN cord-320959-sgdqhtns 221 32 metabolism metabolism NN cord-320959-sgdqhtns 221 33 of of IN cord-320959-sgdqhtns 221 34 α α NN cord-320959-sgdqhtns 221 35 - - HYPH cord-320959-sgdqhtns 221 36 tocopherol tocopherol NN cord-320959-sgdqhtns 221 37 ( ( -LRB- cord-320959-sgdqhtns 221 38 vitamin vitamin NN cord-320959-sgdqhtns 221 39 E e NN cord-320959-sgdqhtns 221 40 ) ) -RRB- cord-320959-sgdqhtns 221 41 Vaping vaping NN cord-320959-sgdqhtns 221 42 - - HYPH cord-320959-sgdqhtns 221 43 Associated Associated NNP cord-320959-sgdqhtns 221 44 Acute Acute NNP cord-320959-sgdqhtns 221 45 10 10 CD cord-320959-sgdqhtns 221 46 Respiratory respiratory JJ cord-320959-sgdqhtns 221 47 Failure failure NN cord-320959-sgdqhtns 222 1 Due due IN cord-320959-sgdqhtns 222 2 to to IN cord-320959-sgdqhtns 222 3 Acute acute JJ cord-320959-sgdqhtns 222 4 Lipoid Lipoid NNP cord-320959-sgdqhtns 222 5 Pneumonia pneumonia NN cord-320959-sgdqhtns 223 1 An an DT cord-320959-sgdqhtns 223 2 animal animal NN cord-320959-sgdqhtns 223 3 model model NN cord-320959-sgdqhtns 223 4 of of IN cord-320959-sgdqhtns 223 5 inhaled inhale VBN cord-320959-sgdqhtns 223 6 Vitamin vitamin NN cord-320959-sgdqhtns 223 7 E e NN cord-320959-sgdqhtns 223 8 acetate acetate NN cord-320959-sgdqhtns 223 9 and and CC cord-320959-sgdqhtns 223 10 Evali Evali NNP cord-320959-sgdqhtns 223 11 - - HYPH cord-320959-sgdqhtns 223 12 like like JJ cord-320959-sgdqhtns 223 13 lung lung NN cord-320959-sgdqhtns 223 14 injury injury NN cord-320959-sgdqhtns 224 1 A a DT cord-320959-sgdqhtns 224 2 woman woman NN cord-320959-sgdqhtns 224 3 who who WP cord-320959-sgdqhtns 224 4 took take VBD cord-320959-sgdqhtns 224 5 cod cod NN cord-320959-sgdqhtns 224 6 - - HYPH cord-320959-sgdqhtns 224 7 liver liver NN cord-320959-sgdqhtns 224 8 oil oil NN cord-320959-sgdqhtns 224 9 and and CC cord-320959-sgdqhtns 224 10 15 15 CD cord-320959-sgdqhtns 224 11 smoked smoke VBD cord-320959-sgdqhtns 224 12 Lipid Lipid NNP cord-320959-sgdqhtns 224 13 - - HYPH cord-320959-sgdqhtns 224 14 laden laden JJ cord-320959-sgdqhtns 224 15 macrophages macrophage NNS cord-320959-sgdqhtns 224 16 as as IN cord-320959-sgdqhtns 224 17 biomarkers biomarker NNS cord-320959-sgdqhtns 224 18 of of IN cord-320959-sgdqhtns 224 19 vaping vaping NN cord-320959-sgdqhtns 224 20 - - HYPH cord-320959-sgdqhtns 224 21 associated associate VBN cord-320959-sgdqhtns 224 22 lung lung NN cord-320959-sgdqhtns 224 23 injury injury NN cord-320959-sgdqhtns 224 24 Antagonistic antagonistic JJ cord-320959-sgdqhtns 224 25 effects effect NNS cord-320959-sgdqhtns 224 26 of of IN cord-320959-sgdqhtns 224 27 oxidized oxidize VBN cord-320959-sgdqhtns 224 28 low low JJ cord-320959-sgdqhtns 224 29 density density NN cord-320959-sgdqhtns 224 30 lipoprotein lipoprotein NN cord-320959-sgdqhtns 224 31 and and CC cord-320959-sgdqhtns 224 32 α α NN cord-320959-sgdqhtns 224 33 - - HYPH cord-320959-sgdqhtns 224 34 tocopherol tocopherol NN cord-320959-sgdqhtns 224 35 on on IN cord-320959-sgdqhtns 224 36 CD36 CD36 NNP cord-320959-sgdqhtns 224 37 scavenger scavenger NN cord-320959-sgdqhtns 224 38 receptor receptor NN cord-320959-sgdqhtns 224 39 20 20 CD cord-320959-sgdqhtns 224 40 expression expression NN cord-320959-sgdqhtns 224 41 in in IN cord-320959-sgdqhtns 224 42 monocytes monocyte NNS cord-320959-sgdqhtns 224 43 : : : cord-320959-sgdqhtns 224 44 Involvement involvement NN cord-320959-sgdqhtns 224 45 of of IN cord-320959-sgdqhtns 224 46 protein protein NN cord-320959-sgdqhtns 224 47 kinase kinase NN cord-320959-sgdqhtns 224 48 B b NN cord-320959-sgdqhtns 224 49 and and CC cord-320959-sgdqhtns 224 50 peroxisome peroxisome NN cord-320959-sgdqhtns 224 51 proliferatoractivated proliferatoractivated JJ cord-320959-sgdqhtns 224 52 receptor receptor NN cord-320959-sgdqhtns 224 53 - - HYPH cord-320959-sgdqhtns 224 54 γ γ NN cord-320959-sgdqhtns 225 1 A a DT cord-320959-sgdqhtns 225 2 CD36-dependent cd36-dependent NN cord-320959-sgdqhtns 225 3 signaling signal VBG cord-320959-sgdqhtns 225 4 cascade cascade NN cord-320959-sgdqhtns 225 5 is be VBZ cord-320959-sgdqhtns 225 6 necessary necessary JJ cord-320959-sgdqhtns 225 7 for for IN cord-320959-sgdqhtns 225 8 macrophage macrophage NN cord-320959-sgdqhtns 225 9 foam foam NN cord-320959-sgdqhtns 225 10 cell cell NN cord-320959-sgdqhtns 225 11 formation formation NN cord-320959-sgdqhtns 225 12 Vitamin vitamin NN cord-320959-sgdqhtns 225 13 E e NN cord-320959-sgdqhtns 225 14 ameliorates ameliorate VBZ cord-320959-sgdqhtns 225 15 ox ox JJ cord-320959-sgdqhtns 225 16 - - HYPH cord-320959-sgdqhtns 225 17 LDL ldl NN cord-320959-sgdqhtns 225 18 - - HYPH cord-320959-sgdqhtns 225 19 induced induce VBN cord-320959-sgdqhtns 225 20 foam foam NN cord-320959-sgdqhtns 225 21 cells cell NNS cord-320959-sgdqhtns 225 22 formation formation NN cord-320959-sgdqhtns 225 23 through through IN cord-320959-sgdqhtns 225 24 modulating modulate VBG cord-320959-sgdqhtns 225 25 the the DT cord-320959-sgdqhtns 225 26 activities activity NNS cord-320959-sgdqhtns 225 27 of of IN cord-320959-sgdqhtns 225 28 oxidative oxidative JJ cord-320959-sgdqhtns 225 29 stress stress NN cord-320959-sgdqhtns 225 30 - - HYPH cord-320959-sgdqhtns 225 31 induced induce VBN cord-320959-sgdqhtns 225 32 NF nf NN cord-320959-sgdqhtns 225 33 - - HYPH cord-320959-sgdqhtns 225 34 κB κB NNP cord-320959-sgdqhtns 225 35 pathway pathway NN cord-320959-sgdqhtns 225 36 Silica silica NN cord-320959-sgdqhtns 225 37 crystals crystal NNS cord-320959-sgdqhtns 225 38 and and CC cord-320959-sgdqhtns 225 39 aluminum aluminum NN cord-320959-sgdqhtns 225 40 salts salt NNS cord-320959-sgdqhtns 225 41 activate activate VBP cord-320959-sgdqhtns 225 42 the the DT cord-320959-sgdqhtns 225 43 NALP3 NALP3 NNP cord-320959-sgdqhtns 225 44 inflammasome inflammasome NNP cord-320959-sgdqhtns 225 45 through through IN cord-320959-sgdqhtns 225 46 phagosomal phagosomal NNP cord-320959-sgdqhtns 225 47 destabilization destabilization NN cord-320959-sgdqhtns 225 48 Electronic Electronic NNP cord-320959-sgdqhtns 225 49 versus versus IN cord-320959-sgdqhtns 225 50 combustible combustible JJ cord-320959-sgdqhtns 225 51 cigarette cigarette NN cord-320959-sgdqhtns 225 52 effects effect NNS cord-320959-sgdqhtns 225 53 on on IN cord-320959-sgdqhtns 225 54 inflammasome inflammasome NN cord-320959-sgdqhtns 225 55 component component NN cord-320959-sgdqhtns 225 56 release release NN cord-320959-sgdqhtns 225 57 into into IN cord-320959-sgdqhtns 225 58 human human JJ cord-320959-sgdqhtns 225 59 lung lung NN cord-320959-sgdqhtns 225 60 Inhibition inhibition NN cord-320959-sgdqhtns 225 61 of of IN cord-320959-sgdqhtns 225 62 5-lipoxygenase 5-lipoxygenase CD cord-320959-sgdqhtns 225 63 by by IN cord-320959-sgdqhtns 225 64 vitamin vitamin NN cord-320959-sgdqhtns 225 65 E e NN cord-320959-sgdqhtns 225 66 Endogenous endogenous JJ cord-320959-sgdqhtns 225 67 metabolites metabolite NNS cord-320959-sgdqhtns 225 68 of of IN cord-320959-sgdqhtns 226 1 vitamin vitamin NN cord-320959-sgdqhtns 226 2 E e CD cord-320959-sgdqhtns 226 3 limit limit NN cord-320959-sgdqhtns 226 4 inflammation inflammation NN cord-320959-sgdqhtns 226 5 by by IN cord-320959-sgdqhtns 226 6 targeting target VBG cord-320959-sgdqhtns 226 7 5-lipoxygenase 5-lipoxygenase CD cord-320959-sgdqhtns 226 8 Diacylglycerol Diacylglycerol NNP cord-320959-sgdqhtns 226 9 - - HYPH cord-320959-sgdqhtns 226 10 Protein Protein NNP cord-320959-sgdqhtns 226 11 Kinase Kinase NNP cord-320959-sgdqhtns 226 12 C C NNP cord-320959-sgdqhtns 226 13 Activation activation NN cord-320959-sgdqhtns 226 14 by by IN cord-320959-sgdqhtns 226 15 Vitamin vitamin NN cord-320959-sgdqhtns 226 16 E e NN cord-320959-sgdqhtns 226 17 in in IN cord-320959-sgdqhtns 226 18 Aorta Aorta NNP cord-320959-sgdqhtns 226 19 of of IN cord-320959-sgdqhtns 226 20 Diabetic diabetic JJ cord-320959-sgdqhtns 226 21 Rats Rats NNPS cord-320959-sgdqhtns 226 22 and and CC cord-320959-sgdqhtns 227 1 Cultured cultured JJ cord-320959-sgdqhtns 227 2 Rat Rat NNP cord-320959-sgdqhtns 227 3 Smooth Smooth NNP cord-320959-sgdqhtns 227 4 Muscle muscle NN cord-320959-sgdqhtns 227 5 Cells cell NNS cord-320959-sgdqhtns 227 6 Exposed expose VBN cord-320959-sgdqhtns 227 7 to to IN cord-320959-sgdqhtns 227 8 Elevated elevated JJ cord-320959-sgdqhtns 227 9 Glucose Glucose NNP cord-320959-sgdqhtns 227 10 Levels Levels NNP cord-320959-sgdqhtns 227 11 α α NN cord-320959-sgdqhtns 227 12 - - HYPH cord-320959-sgdqhtns 227 13 tocopherol tocopherol NN cord-320959-sgdqhtns 227 14 specifically specifically RB cord-320959-sgdqhtns 227 15 inactivates inactivate VBZ cord-320959-sgdqhtns 227 16 cellular cellular JJ cord-320959-sgdqhtns 227 17 protein protein NN cord-320959-sgdqhtns 227 18 kinase kinase NN cord-320959-sgdqhtns 227 19 C c NN cord-320959-sgdqhtns 227 20 α α NN cord-320959-sgdqhtns 227 21 by by IN cord-320959-sgdqhtns 227 22 changing change VBG cord-320959-sgdqhtns 227 23 its -PRON- PRP$ cord-320959-sgdqhtns 227 24 phosphorylation phosphorylation NN cord-320959-sgdqhtns 227 25 state state NN cord-320959-sgdqhtns 228 1 Diacylglycerol Diacylglycerol NNP cord-320959-sgdqhtns 228 2 Kinase Kinase NNP cord-320959-sgdqhtns 228 3 alpha alpha NN cord-320959-sgdqhtns 228 4 is be VBZ cord-320959-sgdqhtns 228 5 Involved involve VBN cord-320959-sgdqhtns 228 6 in in IN cord-320959-sgdqhtns 228 7 the the DT cord-320959-sgdqhtns 228 8 Vitamin vitamin NN cord-320959-sgdqhtns 228 9 E e NN cord-320959-sgdqhtns 228 10 - - HYPH cord-320959-sgdqhtns 228 11 Induced induce VBN cord-320959-sgdqhtns 228 12 Amelioration amelioration NN cord-320959-sgdqhtns 228 13 of of IN cord-320959-sgdqhtns 228 14 Diabetic Diabetic NNP cord-320959-sgdqhtns 228 15 Nephropathy Nephropathy NNP cord-320959-sgdqhtns 228 16 in in IN cord-320959-sgdqhtns 228 17 Mice Mice NNP cord-320959-sgdqhtns 228 18 Importance Importance NNP cord-320959-sgdqhtns 228 19 of of IN cord-320959-sgdqhtns 228 20 chroman chroman NN cord-320959-sgdqhtns 228 21 ring ring NN cord-320959-sgdqhtns 228 22 and and CC cord-320959-sgdqhtns 228 23 tyrosine tyrosine NN cord-320959-sgdqhtns 228 24 Endothelial endothelial JJ cord-320959-sgdqhtns 228 25 relaxation relaxation NN cord-320959-sgdqhtns 229 1 is be VBZ cord-320959-sgdqhtns 229 2 disturbed disturb VBN cord-320959-sgdqhtns 229 3 by by IN cord-320959-sgdqhtns 229 4 oxidative oxidative JJ cord-320959-sgdqhtns 229 5 stress stress NN cord-320959-sgdqhtns 229 6 in in IN cord-320959-sgdqhtns 229 7 the the DT cord-320959-sgdqhtns 229 8 diabetic diabetic JJ cord-320959-sgdqhtns 229 9 rat rat NN cord-320959-sgdqhtns 229 10 heart heart NN cord-320959-sgdqhtns 229 11 : : : cord-320959-sgdqhtns 229 12 influence influence NN cord-320959-sgdqhtns 229 13 of of IN cord-320959-sgdqhtns 229 14 tocopherol tocopherol NN cord-320959-sgdqhtns 229 15 as as IN cord-320959-sgdqhtns 229 16 antioxidant antioxidant NN cord-320959-sgdqhtns 229 17 Intracellular Intracellular NNP cord-320959-sgdqhtns 229 18 diacylglycerol diacylglycerol NN cord-320959-sgdqhtns 229 19 : : : cord-320959-sgdqhtns 230 1 A a DT cord-320959-sgdqhtns 230 2 mitogenic mitogenic NNP cord-320959-sgdqhtns 230 3 second second JJ cord-320959-sgdqhtns 230 4 messenger messenger NN cord-320959-sgdqhtns 230 5 proposable proposable NN cord-320959-sgdqhtns 230 6 as as IN cord-320959-sgdqhtns 230 7 marker marker NN cord-320959-sgdqhtns 230 8 of of IN cord-320959-sgdqhtns 230 9 transformation transformation NN cord-320959-sgdqhtns 230 10 in in IN cord-320959-sgdqhtns 230 11 15 15 CD cord-320959-sgdqhtns 230 12 squamous squamous JJ cord-320959-sgdqhtns 230 13 cell cell NN cord-320959-sgdqhtns 230 14 carcinoma carcinoma NN cord-320959-sgdqhtns 230 15 of of IN cord-320959-sgdqhtns 230 16 the the DT cord-320959-sgdqhtns 230 17 lung lung NN cord-320959-sgdqhtns 230 18 α α NN cord-320959-sgdqhtns 230 19 - - HYPH cord-320959-sgdqhtns 230 20 Tocopherol tocopherol NN cord-320959-sgdqhtns 230 21 inhibits inhibit VBZ cord-320959-sgdqhtns 230 22 the the DT cord-320959-sgdqhtns 230 23 respiratory respiratory JJ cord-320959-sgdqhtns 230 24 burst burst NN cord-320959-sgdqhtns 230 25 in in IN cord-320959-sgdqhtns 230 26 human human JJ cord-320959-sgdqhtns 230 27 monocytes monocyte NNS cord-320959-sgdqhtns 230 28 : : : cord-320959-sgdqhtns 231 1 Attenuation attenuation NN cord-320959-sgdqhtns 231 2 of of IN cord-320959-sgdqhtns 231 3 p47(phox p47(phox NNP cord-320959-sgdqhtns 231 4 ) ) -RRB- cord-320959-sgdqhtns 231 5 membrane membrane NN cord-320959-sgdqhtns 231 6 translocation translocation NN cord-320959-sgdqhtns 231 7 and and CC cord-320959-sgdqhtns 231 8 phosphorylation phosphorylation NN cord-320959-sgdqhtns 231 9 Opposing oppose VBG cord-320959-sgdqhtns 231 10 Immunoregulatory Immunoregulatory NNP cord-320959-sgdqhtns 231 11 Functions Functions NNPS cord-320959-sgdqhtns 231 12 during during IN cord-320959-sgdqhtns 231 13 Inflammation inflammation NN cord-320959-sgdqhtns 231 14 by by IN cord-320959-sgdqhtns 231 15 Regulating regulate VBG cord-320959-sgdqhtns 231 16 Leukocyte Leukocyte NNP cord-320959-sgdqhtns 231 17 Recruitment Recruitment NNP cord-320959-sgdqhtns 232 1 The the DT cord-320959-sgdqhtns 232 2 α α NN cord-320959-sgdqhtns 232 3 - - HYPH cord-320959-sgdqhtns 232 4 Tocopherol tocopherol NN cord-320959-sgdqhtns 232 5 Form form NN cord-320959-sgdqhtns 232 6 of of IN cord-320959-sgdqhtns 232 7 Vitamin vitamin NN cord-320959-sgdqhtns 232 8 E e NN cord-320959-sgdqhtns 232 9 Reverses reverse VBZ cord-320959-sgdqhtns 232 10 Age Age NNP cord-320959-sgdqhtns 232 11 - - HYPH cord-320959-sgdqhtns 232 12 Associated Associated NNP cord-320959-sgdqhtns 232 13 Susceptibility Susceptibility NNP cord-320959-sgdqhtns 232 14 to to IN cord-320959-sgdqhtns 232 15 Streptococcus streptococcus NN cord-320959-sgdqhtns 232 16 pneumoniae pneumoniae NN cord-320959-sgdqhtns 232 17 Lung lung NN cord-320959-sgdqhtns 232 18 Infection infection NN cord-320959-sgdqhtns 232 19 by by IN cord-320959-sgdqhtns 232 20 Modulating modulate VBG cord-320959-sgdqhtns 232 21 Pulmonary Pulmonary NNP cord-320959-sgdqhtns 232 22 Neutrophil Neutrophil NNP cord-320959-sgdqhtns 232 23 Recruitment Recruitment NNP cord-320959-sgdqhtns 233 1 The the DT cord-320959-sgdqhtns 233 2 Alpha alpha NN cord-320959-sgdqhtns 233 3 - - HYPH cord-320959-sgdqhtns 233 4 Tocopherol tocopherol NN cord-320959-sgdqhtns 233 5 Form form NN cord-320959-sgdqhtns 233 6 of of IN cord-320959-sgdqhtns 233 7 Vitamin vitamin NN cord-320959-sgdqhtns 233 8 E e NN cord-320959-sgdqhtns 233 9 Boosts boost VBZ cord-320959-sgdqhtns 233 10 Elastase Elastase NNP cord-320959-sgdqhtns 233 11 Activity Activity NNP cord-320959-sgdqhtns 233 12 of of IN cord-320959-sgdqhtns 233 13 Human Human NNP cord-320959-sgdqhtns 233 14 PMNs pmn NNS cord-320959-sgdqhtns 233 15 and and CC cord-320959-sgdqhtns 233 16 Their -PRON- PRP$ cord-320959-sgdqhtns 233 17 Ability ability NN cord-320959-sgdqhtns 233 18 to to TO cord-320959-sgdqhtns 233 19 Kill kill VB cord-320959-sgdqhtns 233 20 Streptococcus Streptococcus NNP cord-320959-sgdqhtns 233 21 pneumoniae pneumoniae NN cord-320959-sgdqhtns 233 22 Vitamin vitamin NN cord-320959-sgdqhtns 233 23 E e NN cord-320959-sgdqhtns 233 24 Biotransformation Biotransformation NNP cord-320959-sgdqhtns 233 25 in in IN cord-320959-sgdqhtns 233 26 Humans human NNS cord-320959-sgdqhtns 234 1 The the DT cord-320959-sgdqhtns 234 2 long long JJ cord-320959-sgdqhtns 234 3 chain chain NN cord-320959-sgdqhtns 234 4 α α NN cord-320959-sgdqhtns 234 5 - - HYPH cord-320959-sgdqhtns 234 6 tocopherol tocopherol NN cord-320959-sgdqhtns 234 7 metabolite metabolite NN cord-320959-sgdqhtns 234 8 α-13'-COOH α-13'-cooh CD cord-320959-sgdqhtns 234 9 and and CC cord-320959-sgdqhtns 234 10 γ γ NN cord-320959-sgdqhtns 234 11 - - HYPH cord-320959-sgdqhtns 234 12 tocotrienol tocotrienol NNP cord-320959-sgdqhtns 234 13 induce induce VBP cord-320959-sgdqhtns 234 14 P p NN cord-320959-sgdqhtns 234 15 - - HYPH cord-320959-sgdqhtns 234 16 glycoprotein glycoprotein NN cord-320959-sgdqhtns 234 17 expression expression NN cord-320959-sgdqhtns 234 18 and and CC cord-320959-sgdqhtns 234 19 activity activity NN cord-320959-sgdqhtns 234 20 by by IN cord-320959-sgdqhtns 234 21 activation activation NN cord-320959-sgdqhtns 234 22 of of IN cord-320959-sgdqhtns 234 23 the the DT cord-320959-sgdqhtns 234 24 pregnane pregnane NNP cord-320959-sgdqhtns 234 25 X X NNP cord-320959-sgdqhtns 234 26 receptor receptor NN cord-320959-sgdqhtns 234 27 in in IN cord-320959-sgdqhtns 234 28 the the DT cord-320959-sgdqhtns 234 29 intestinal intestinal JJ cord-320959-sgdqhtns 234 30 cell cell NN cord-320959-sgdqhtns 234 31 line line NN cord-320959-sgdqhtns 234 32 LS LS NNP cord-320959-sgdqhtns 234 33 180 180 CD cord-320959-sgdqhtns 234 34 Garcinoic Garcinoic NNP cord-320959-sgdqhtns 234 35 Acid Acid NNP cord-320959-sgdqhtns 235 1 Is be VBZ cord-320959-sgdqhtns 235 2 a a DT cord-320959-sgdqhtns 235 3 Natural natural JJ cord-320959-sgdqhtns 235 4 and and CC cord-320959-sgdqhtns 235 5 Selective selective JJ cord-320959-sgdqhtns 235 6 Agonist agonist NN cord-320959-sgdqhtns 235 7 of of IN cord-320959-sgdqhtns 235 8 Pregnane Pregnane NNP cord-320959-sgdqhtns 235 9 X X NNP cord-320959-sgdqhtns 235 10 Receptor Receptor NNP cord-320959-sgdqhtns 236 1 The the DT cord-320959-sgdqhtns 236 2 Nuclear Nuclear NNP cord-320959-sgdqhtns 236 3 Pregnane Pregnane NNP cord-320959-sgdqhtns 236 4 X X NNP cord-320959-sgdqhtns 236 5 Receptor Receptor NNP cord-320959-sgdqhtns 236 6 : : : cord-320959-sgdqhtns 236 7 A a DT cord-320959-sgdqhtns 236 8 Key key JJ cord-320959-sgdqhtns 236 9 Regulator Regulator NNP cord-320959-sgdqhtns 236 10 of of IN cord-320959-sgdqhtns 236 11 Xenobiotic Xenobiotic NNP cord-320959-sgdqhtns 236 12 Metabolism Metabolism NNP cord-320959-sgdqhtns 236 13 Relationship relationship NN cord-320959-sgdqhtns 236 14 between between IN cord-320959-sgdqhtns 236 15 drug drug NN cord-320959-sgdqhtns 236 16 - - HYPH cord-320959-sgdqhtns 236 17 induced induce VBN cord-320959-sgdqhtns 236 18 interstitial interstitial JJ cord-320959-sgdqhtns 236 19 lung lung NN cord-320959-sgdqhtns 236 20 diseases disease NNS cord-320959-sgdqhtns 236 21 and and CC cord-320959-sgdqhtns 236 22 cytochrome cytochrome NN cord-320959-sgdqhtns 236 23 P450 p450 JJ cord-320959-sgdqhtns 236 24 polymorphisms polymorphism NNS cord-320959-sgdqhtns 236 25 Drug Drug NNP cord-320959-sgdqhtns 236 26 Induced induce VBN cord-320959-sgdqhtns 236 27 Interstitial Interstitial NNP cord-320959-sgdqhtns 236 28 Lung Lung NNP cord-320959-sgdqhtns 236 29 Disease Disease NNP cord-320959-sgdqhtns 236 30 Drug Drug NNP cord-320959-sgdqhtns 236 31 - - HYPH cord-320959-sgdqhtns 236 32 induced induce VBN cord-320959-sgdqhtns 236 33 interstitial interstitial JJ cord-320959-sgdqhtns 236 34 lung lung NN cord-320959-sgdqhtns 236 35 disease disease NN cord-320959-sgdqhtns 236 36 : : : cord-320959-sgdqhtns 237 1 Mechanisms mechanism NNS cord-320959-sgdqhtns 237 2 and and CC cord-320959-sgdqhtns 237 3 best well RBS cord-320959-sgdqhtns 237 4 diagnostic diagnostic JJ cord-320959-sgdqhtns 237 5 20 20 CD cord-320959-sgdqhtns 237 6 approaches approach NNS cord-320959-sgdqhtns 237 7 Role role NN cord-320959-sgdqhtns 237 8 of of IN cord-320959-sgdqhtns 237 9 cytochrome cytochrome NN cord-320959-sgdqhtns 237 10 P450 p450 JJ cord-320959-sgdqhtns 237 11 polymorphisms polymorphism NNS cord-320959-sgdqhtns 237 12 in in IN cord-320959-sgdqhtns 237 13 the the DT cord-320959-sgdqhtns 237 14 development development NN cord-320959-sgdqhtns 237 15 of of IN cord-320959-sgdqhtns 237 16 pulmonary pulmonary JJ cord-320959-sgdqhtns 237 17 drug drug NN cord-320959-sgdqhtns 237 18 toxicity toxicity NN cord-320959-sgdqhtns 237 19 : : : cord-320959-sgdqhtns 238 1 A a DT cord-320959-sgdqhtns 238 2 case case NN cord-320959-sgdqhtns 238 3 - - HYPH cord-320959-sgdqhtns 238 4 control control NN cord-320959-sgdqhtns 238 5 study study NN cord-320959-sgdqhtns 238 6 in in IN cord-320959-sgdqhtns 238 7 the the DT cord-320959-sgdqhtns 238 8 Netherlands Netherlands NNP cord-320959-sgdqhtns 238 9 Whole Whole NNP cord-320959-sgdqhtns 238 10 genome genome NN cord-320959-sgdqhtns 238 11 sequencing sequencing NN cord-320959-sgdqhtns 238 12 to to TO cord-320959-sgdqhtns 238 13 identify identify VB cord-320959-sgdqhtns 238 14 predictive predictive JJ cord-320959-sgdqhtns 238 15 markers marker NNS cord-320959-sgdqhtns 238 16 for for IN cord-320959-sgdqhtns 238 17 the the DT cord-320959-sgdqhtns 238 18 risk risk NN cord-320959-sgdqhtns 238 19 of of IN cord-320959-sgdqhtns 238 20 drug drug NN cord-320959-sgdqhtns 238 21 - - HYPH cord-320959-sgdqhtns 238 22 induced induce VBN cord-320959-sgdqhtns 238 23 interstitial interstitial JJ cord-320959-sgdqhtns 238 24 lung lung NN cord-320959-sgdqhtns 238 25 disease disease NNP cord-320959-sgdqhtns 238 26 pregnane pregnane NNP cord-320959-sgdqhtns 238 27 X X NNP cord-320959-sgdqhtns 238 28 receptor receptor NN cord-320959-sgdqhtns 238 29 and and CC cord-320959-sgdqhtns 238 30 retinoid retinoid NN cord-320959-sgdqhtns 238 31 X x NN cord-320959-sgdqhtns 238 32 receptor receptor NN cord-320959-sgdqhtns 238 33 - - HYPH cord-320959-sgdqhtns 238 34 α α NN cord-320959-sgdqhtns 238 35 expression expression NN cord-320959-sgdqhtns 238 36 in in IN cord-320959-sgdqhtns 238 37 human human JJ cord-320959-sgdqhtns 238 38 hepatocytes hepatocyte NNS cord-320959-sgdqhtns 238 39 : : : cord-320959-sgdqhtns 239 1 Synergistic synergistic JJ cord-320959-sgdqhtns 239 2 increase increase NN cord-320959-sgdqhtns 239 3 of of IN cord-320959-sgdqhtns 239 4 CYP3A4 cyp3a4 JJ cord-320959-sgdqhtns 239 5 induction induction NN cord-320959-sgdqhtns 239 6 by by IN cord-320959-sgdqhtns 239 7 pregnane pregnane NNP cord-320959-sgdqhtns 239 8 X X NNP cord-320959-sgdqhtns 239 9 receptor receptor NN cord-320959-sgdqhtns 239 10 activators activator NNS cord-320959-sgdqhtns 239 11 PXR pxr NN cord-320959-sgdqhtns 239 12 - - HYPH cord-320959-sgdqhtns 239 13 mediated mediate VBN cord-320959-sgdqhtns 239 14 induction induction NN cord-320959-sgdqhtns 239 15 of of IN cord-320959-sgdqhtns 239 16 human human JJ cord-320959-sgdqhtns 239 17 CYP3A4 CYP3A4 NNP cord-320959-sgdqhtns 239 18 and and CC cord-320959-sgdqhtns 239 19 mouse mouse NN cord-320959-sgdqhtns 239 20 Cyp3a11 Cyp3a11 VBN cord-320959-sgdqhtns 239 21 by by IN cord-320959-sgdqhtns 239 22 the the DT cord-320959-sgdqhtns 239 23 glucocorticoid glucocorticoid NN cord-320959-sgdqhtns 239 24 10 10 CD cord-320959-sgdqhtns 239 25 budesonide budesonide NNP cord-320959-sgdqhtns 239 26 Identification identification NN cord-320959-sgdqhtns 239 27 and and CC cord-320959-sgdqhtns 239 28 validation validation NN cord-320959-sgdqhtns 239 29 of of IN cord-320959-sgdqhtns 239 30 novel novel JJ cord-320959-sgdqhtns 239 31 human human NNP cord-320959-sgdqhtns 239 32 pregnane pregnane NNP cord-320959-sgdqhtns 239 33 X X NNP cord-320959-sgdqhtns 239 34 receptor receptor NN cord-320959-sgdqhtns 239 35 activators activator NNS cord-320959-sgdqhtns 239 36 among among IN cord-320959-sgdqhtns 239 37 prescribed prescribed JJ cord-320959-sgdqhtns 239 38 drugs drug NNS cord-320959-sgdqhtns 239 39 via via IN cord-320959-sgdqhtns 239 40 ligand ligand NN cord-320959-sgdqhtns 239 41 - - HYPH cord-320959-sgdqhtns 239 42 based base VBN cord-320959-sgdqhtns 239 43 virtual virtual JJ cord-320959-sgdqhtns 239 44 screening screening NN cord-320959-sgdqhtns 239 45 Effectiveness Effectiveness NNP cord-320959-sgdqhtns 239 46 of of IN cord-320959-sgdqhtns 239 47 High High NNP cord-320959-sgdqhtns 239 48 Repeated repeat VBN cord-320959-sgdqhtns 239 49 Doses Doses NNPS cord-320959-sgdqhtns 239 50 of of IN cord-320959-sgdqhtns 239 51 15 15 CD cord-320959-sgdqhtns 239 52 Inhaled inhale VBN cord-320959-sgdqhtns 239 53 Budesonide Budesonide NNP cord-320959-sgdqhtns 239 54 or or CC cord-320959-sgdqhtns 239 55 Fluticasone Fluticasone NNP cord-320959-sgdqhtns 239 56 in in IN cord-320959-sgdqhtns 239 57 Controlling control VBG cord-320959-sgdqhtns 239 58 Acute Acute NNP cord-320959-sgdqhtns 239 59 Asthma Asthma NNP cord-320959-sgdqhtns 239 60 Exacerbations Exacerbations NNPS cord-320959-sgdqhtns 239 61 in in IN cord-320959-sgdqhtns 239 62 Young Young NNP cord-320959-sgdqhtns 239 63 Children Children NNP cord-320959-sgdqhtns 239 64 E E NNS cord-320959-sgdqhtns 239 65 - - NNS cord-320959-sgdqhtns 239 66 cigarettes cigarette NNS cord-320959-sgdqhtns 239 67 induce induce VBP cord-320959-sgdqhtns 239 68 toxicological toxicological JJ cord-320959-sgdqhtns 239 69 effects effect NNS cord-320959-sgdqhtns 239 70 that that WDT cord-320959-sgdqhtns 239 71 can can MD cord-320959-sgdqhtns 239 72 raise raise VB cord-320959-sgdqhtns 239 73 the the DT cord-320959-sgdqhtns 239 74 cancer cancer NN cord-320959-sgdqhtns 239 75 risk risk NN cord-320959-sgdqhtns 239 76 Cholesterol cholesterol NN cord-320959-sgdqhtns 239 77 as as IN cord-320959-sgdqhtns 239 78 a a DT cord-320959-sgdqhtns 239 79 co co NN cord-320959-sgdqhtns 239 80 - - NN cord-320959-sgdqhtns 239 81 solvent solvent NN cord-320959-sgdqhtns 239 82 and and CC cord-320959-sgdqhtns 239 83 a a DT cord-320959-sgdqhtns 239 84 ligand ligand NN cord-320959-sgdqhtns 239 85 for for IN cord-320959-sgdqhtns 239 86 20 20 CD cord-320959-sgdqhtns 239 87 membrane membrane NN cord-320959-sgdqhtns 239 88 proteins protein NNS cord-320959-sgdqhtns 239 89 Tuning tune VBG cord-320959-sgdqhtns 239 90 membrane membrane NN cord-320959-sgdqhtns 239 91 phase phase NN cord-320959-sgdqhtns 239 92 separation separation NN cord-320959-sgdqhtns 239 93 using use VBG cord-320959-sgdqhtns 239 94 nonlipid nonlipid NNP cord-320959-sgdqhtns 239 95 amphiphiles amphiphiles NNPS cord-320959-sgdqhtns 239 96 Effects effect NNS cord-320959-sgdqhtns 239 97 of of IN cord-320959-sgdqhtns 239 98 vitamin vitamin NN cord-320959-sgdqhtns 239 99 E e NN cord-320959-sgdqhtns 239 100 and and CC cord-320959-sgdqhtns 239 101 C C NNP cord-320959-sgdqhtns 239 102 supplementation supplementation NN cord-320959-sgdqhtns 239 103 on on IN cord-320959-sgdqhtns 239 104 oxidative oxidative JJ cord-320959-sgdqhtns 239 105 stress stress NN cord-320959-sgdqhtns 239 106 and and CC cord-320959-sgdqhtns 239 107 viral viral JJ cord-320959-sgdqhtns 239 108 load load NN cord-320959-sgdqhtns 239 109 in in IN cord-320959-sgdqhtns 239 110 HIV HIV NNP cord-320959-sgdqhtns 239 111 - - HYPH cord-320959-sgdqhtns 239 112 infected infect VBN cord-320959-sgdqhtns 239 113 subjects subject NNS cord-320959-sgdqhtns 239 114 Line line NN cord-320959-sgdqhtns 239 115 tension tension NN cord-320959-sgdqhtns 239 116 at at IN cord-320959-sgdqhtns 239 117 lipid lipid NN cord-320959-sgdqhtns 239 118 phase phase NN cord-320959-sgdqhtns 239 119 boundaries boundary NNS cord-320959-sgdqhtns 239 120 as as IN cord-320959-sgdqhtns 239 121 driving drive VBG cord-320959-sgdqhtns 239 122 force force NN cord-320959-sgdqhtns 239 123 for for IN cord-320959-sgdqhtns 239 124 HIV HIV NNP cord-320959-sgdqhtns 239 125 fusion fusion NN cord-320959-sgdqhtns 239 126 peptide peptide NN cord-320959-sgdqhtns 239 127 - - HYPH cord-320959-sgdqhtns 239 128 mediated mediate VBN cord-320959-sgdqhtns 239 129 fusion fusion NN cord-320959-sgdqhtns 239 130 HIV HIV NNP cord-320959-sgdqhtns 239 131 virions virion NNS cord-320959-sgdqhtns 239 132 sense sense VBP cord-320959-sgdqhtns 239 133 plasma plasma NN cord-320959-sgdqhtns 239 134 membrane membrane NN cord-320959-sgdqhtns 239 135 heterogeneity heterogeneity NN cord-320959-sgdqhtns 239 136 for for IN cord-320959-sgdqhtns 239 137 cell cell NN cord-320959-sgdqhtns 239 138 entry entry NN cord-320959-sgdqhtns 239 139 Line line NN cord-320959-sgdqhtns 239 140 active active JJ cord-320959-sgdqhtns 239 141 molecules molecule NNS cord-320959-sgdqhtns 239 142 promote promote VBP cord-320959-sgdqhtns 239 143 inhomogeneous inhomogeneous JJ cord-320959-sgdqhtns 239 144 structures structure NNS cord-320959-sgdqhtns 239 145 in in IN cord-320959-sgdqhtns 239 146 membranes membrane NNS cord-320959-sgdqhtns 239 147 : : : cord-320959-sgdqhtns 239 148 Theory theory NN cord-320959-sgdqhtns 239 149 , , , cord-320959-sgdqhtns 239 150 simulations simulation NNS cord-320959-sgdqhtns 239 151 and and CC cord-320959-sgdqhtns 239 152 experiments experiment NNS cord-320959-sgdqhtns 239 153 Capillarity Capillarity NNP cord-320959-sgdqhtns 239 154 and and CC cord-320959-sgdqhtns 239 155 Wetting Wetting NNP cord-320959-sgdqhtns 239 156 Phenomena Phenomena NNP cord-320959-sgdqhtns 240 1 The the DT cord-320959-sgdqhtns 240 2 antioxidant antioxidant JJ cord-320959-sgdqhtns 240 3 vitamin vitamin NN cord-320959-sgdqhtns 240 4 E e NN cord-320959-sgdqhtns 240 5 as as IN cord-320959-sgdqhtns 240 6 a a DT cord-320959-sgdqhtns 240 7 membrane membrane NN cord-320959-sgdqhtns 240 8 raft raft NN cord-320959-sgdqhtns 240 9 modulator modulator NN cord-320959-sgdqhtns 240 10 : : : cord-320959-sgdqhtns 241 1 Tocopherols Tocopherols NNP cord-320959-sgdqhtns 241 2 do do VBP cord-320959-sgdqhtns 241 3 not not RB cord-320959-sgdqhtns 241 4 abolish abolish VB cord-320959-sgdqhtns 241 5 lipid lipid NN cord-320959-sgdqhtns 241 6 domains domain NNS cord-320959-sgdqhtns 241 7 Effect effect NN cord-320959-sgdqhtns 241 8 of of IN cord-320959-sgdqhtns 241 9 cholesterol cholesterol NN cord-320959-sgdqhtns 241 10 and and CC cord-320959-sgdqhtns 241 11 surfactant surfactant NN cord-320959-sgdqhtns 241 12 protein protein NN cord-320959-sgdqhtns 241 13 B B NNP cord-320959-sgdqhtns 241 14 on on IN cord-320959-sgdqhtns 241 15 the the DT cord-320959-sgdqhtns 241 16 viscosity viscosity NN cord-320959-sgdqhtns 241 17 of of IN cord-320959-sgdqhtns 241 18 phospholipid phospholipid NN cord-320959-sgdqhtns 241 19 mixtures mixture NNS cord-320959-sgdqhtns 241 20 Effect Effect NNP cord-320959-sgdqhtns 241 21 of of IN cord-320959-sgdqhtns 241 22 cholesterol cholesterol NN cord-320959-sgdqhtns 241 23 nanodomains nanodomain NNS cord-320959-sgdqhtns 241 24 on on IN cord-320959-sgdqhtns 241 25 monolayer monolayer NN cord-320959-sgdqhtns 241 26 morphology morphology NN cord-320959-sgdqhtns 241 27 and and CC cord-320959-sgdqhtns 241 28 dynamics dynamic NNS cord-320959-sgdqhtns 241 29 In in IN cord-320959-sgdqhtns 241 30 - - HYPH cord-320959-sgdqhtns 241 31 Plane Plane NNP cord-320959-sgdqhtns 241 32 Steady Steady NNP cord-320959-sgdqhtns 241 33 Shear Shear NNP cord-320959-sgdqhtns 241 34 Viscosity Viscosity NNP cord-320959-sgdqhtns 241 35 of of IN cord-320959-sgdqhtns 241 36 Monolayers Monolayers NNPS cord-320959-sgdqhtns 241 37 at at IN cord-320959-sgdqhtns 241 38 the the DT cord-320959-sgdqhtns 241 39 Air Air NNP cord-320959-sgdqhtns 241 40 / / SYM cord-320959-sgdqhtns 241 41 Water Water NNP cord-320959-sgdqhtns 241 42 Interface Interface NNP cord-320959-sgdqhtns 241 43 and and CC cord-320959-sgdqhtns 241 44 Its -PRON- PRP$ cord-320959-sgdqhtns 241 45 Dependence dependence NN cord-320959-sgdqhtns 241 46 on on IN cord-320959-sgdqhtns 241 47 Free Free NNP cord-320959-sgdqhtns 241 48 Area Area NNP cord-320959-sgdqhtns 241 49 Effect Effect NNP cord-320959-sgdqhtns 241 50 of of IN cord-320959-sgdqhtns 241 51 hyperpnea hyperpnea NN cord-320959-sgdqhtns 241 52 on on IN cord-320959-sgdqhtns 241 53 the the DT cord-320959-sgdqhtns 241 54 cholesterol cholesterol NN cord-320959-sgdqhtns 241 55 to to IN cord-320959-sgdqhtns 241 56 disaturated disaturated JJ cord-320959-sgdqhtns 241 57 phospholipid phospholipid NN cord-320959-sgdqhtns 241 58 ratio ratio NN cord-320959-sgdqhtns 241 59 in in IN cord-320959-sgdqhtns 241 60 alveolar alveolar JJ cord-320959-sgdqhtns 241 61 surfactant surfactant NN cord-320959-sgdqhtns 241 62 of of IN cord-320959-sgdqhtns 241 63 rats rat NNS cord-320959-sgdqhtns 241 64 Hypoxia hypoxia IN cord-320959-sgdqhtns 241 65 converts convert VBZ cord-320959-sgdqhtns 241 66 human human JJ cord-320959-sgdqhtns 241 67 macrophages macrophage NNS cord-320959-sgdqhtns 241 68 into into IN cord-320959-sgdqhtns 241 69 triglyceride triglyceride NN cord-320959-sgdqhtns 241 70 - - HYPH cord-320959-sgdqhtns 241 71 loaded load VBN cord-320959-sgdqhtns 241 72 foam foam NN cord-320959-sgdqhtns 241 73 cells cell NNS cord-320959-sgdqhtns 242 1 Lysosomal Lysosomal NNP cord-320959-sgdqhtns 242 2 alterations alteration NNS cord-320959-sgdqhtns 242 3 in in IN cord-320959-sgdqhtns 242 4 hypoxic hypoxic JJ cord-320959-sgdqhtns 242 5 and and CC cord-320959-sgdqhtns 242 6 reoxygenated reoxygenated JJ cord-320959-sgdqhtns 242 7 hearts heart NNS cord-320959-sgdqhtns 242 8 . . . cord-320959-sgdqhtns 243 1 I -PRON- PRP cord-320959-sgdqhtns 243 2 Ultrastructural Ultrastructural NNP cord-320959-sgdqhtns 243 3 and and CC cord-320959-sgdqhtns 243 4 cytochemical cytochemical JJ cord-320959-sgdqhtns 243 5 changes change VBZ cord-320959-sgdqhtns 243 6 HIF HIF NNP cord-320959-sgdqhtns 243 7 and and CC cord-320959-sgdqhtns 243 8 the the DT cord-320959-sgdqhtns 243 9 lung lung NN cord-320959-sgdqhtns 243 10 : : : cord-320959-sgdqhtns 243 11 Role role NN cord-320959-sgdqhtns 243 12 of of IN cord-320959-sgdqhtns 243 13 hypoxia hypoxia NN cord-320959-sgdqhtns 243 14 - - HYPH cord-320959-sgdqhtns 243 15 inducible inducible JJ cord-320959-sgdqhtns 243 16 factors factor NNS cord-320959-sgdqhtns 243 17 in in IN cord-320959-sgdqhtns 243 18 pulmonary pulmonary JJ cord-320959-sgdqhtns 243 19 development development NN cord-320959-sgdqhtns 243 20 and and CC cord-320959-sgdqhtns 243 21 disease disease NN cord-320959-sgdqhtns 243 22 Partial partial JJ cord-320959-sgdqhtns 243 23 deficiency deficiency NN cord-320959-sgdqhtns 243 24 of of IN cord-320959-sgdqhtns 243 25 surfactant surfactant NN cord-320959-sgdqhtns 243 26 protein protein NN cord-320959-sgdqhtns 243 27 B b NN cord-320959-sgdqhtns 243 28 in in IN cord-320959-sgdqhtns 243 29 an an DT cord-320959-sgdqhtns 243 30 infant infant NN cord-320959-sgdqhtns 243 31 with with IN cord-320959-sgdqhtns 243 32 chronic chronic JJ cord-320959-sgdqhtns 243 33 lung lung NN cord-320959-sgdqhtns 243 34 disease disease NN cord-320959-sgdqhtns 243 35 Vitamin vitamin NN cord-320959-sgdqhtns 243 36 E e NN cord-320959-sgdqhtns 243 37 : : : cord-320959-sgdqhtns 243 38 Regulatory regulatory JJ cord-320959-sgdqhtns 243 39 Role role NN cord-320959-sgdqhtns 243 40 on on IN cord-320959-sgdqhtns 243 41 Signal Signal NNP cord-320959-sgdqhtns 243 42 Transduction Transduction NNP cord-320959-sgdqhtns 243 43 Functional functional JJ cord-320959-sgdqhtns 243 44 rafts raft NNS cord-320959-sgdqhtns 243 45 in in IN cord-320959-sgdqhtns 243 46 cell cell NN cord-320959-sgdqhtns 243 47 membranes membrane NNS cord-320959-sgdqhtns 244 1 The the DT cord-320959-sgdqhtns 244 2 NK1 nk1 JJ cord-320959-sgdqhtns 244 3 receptor receptor NN cord-320959-sgdqhtns 244 4 localizes localize VBZ cord-320959-sgdqhtns 244 5 to to IN cord-320959-sgdqhtns 244 6 the the DT cord-320959-sgdqhtns 244 7 plasma plasma NN cord-320959-sgdqhtns 244 8 membrane membrane NN cord-320959-sgdqhtns 244 9 microdomains microdomain NNS cord-320959-sgdqhtns 244 10 , , , cord-320959-sgdqhtns 244 11 and and CC cord-320959-sgdqhtns 244 12 its -PRON- PRP$ cord-320959-sgdqhtns 244 13 activation activation NN cord-320959-sgdqhtns 244 14 is be VBZ cord-320959-sgdqhtns 244 15 dependent dependent JJ cord-320959-sgdqhtns 244 16 on on IN cord-320959-sgdqhtns 244 17 lipid lipid NN cord-320959-sgdqhtns 244 18 raft raft NN cord-320959-sgdqhtns 244 19 integrity integrity NN cord-320959-sgdqhtns 244 20 Protein Protein NNP cord-320959-sgdqhtns 244 21 profiling profiling NN cord-320959-sgdqhtns 244 22 of of IN cord-320959-sgdqhtns 244 23 plasma plasma NN cord-320959-sgdqhtns 244 24 membranes membrane NNS cord-320959-sgdqhtns 244 25 defines define VBZ cord-320959-sgdqhtns 244 26 aberrant aberrant JJ cord-320959-sgdqhtns 244 27 signaling signal VBG cord-320959-sgdqhtns 244 28 pathways pathway NNS cord-320959-sgdqhtns 244 29 in in IN cord-320959-sgdqhtns 244 30 mantle mantle NN cord-320959-sgdqhtns 244 31 cell cell NN cord-320959-sgdqhtns 244 32 lymphoma lymphoma NN cord-320959-sgdqhtns 244 33 Molecular Molecular NNP cord-320959-sgdqhtns 244 34 Insight Insight NNP cord-320959-sgdqhtns 244 35 into into IN cord-320959-sgdqhtns 244 36 the the DT cord-320959-sgdqhtns 244 37 Line Line NNP cord-320959-sgdqhtns 244 38 Tension tension NN cord-320959-sgdqhtns 244 39 of of IN cord-320959-sgdqhtns 244 40 Bilayer Bilayer NNP cord-320959-sgdqhtns 244 41 20 20 CD cord-320959-sgdqhtns 244 42 Membranes membrane NNS cord-320959-sgdqhtns 244 43 Containing contain VBG cord-320959-sgdqhtns 244 44 Hybrid Hybrid NNP cord-320959-sgdqhtns 244 45 Polyunsaturated Polyunsaturated NNP cord-320959-sgdqhtns 244 46 Lipids Lipids NNP cord-320959-sgdqhtns 244 47 Partitioning partitioning NN cord-320959-sgdqhtns 244 48 of of IN cord-320959-sgdqhtns 244 49 lipids lipid NNS cord-320959-sgdqhtns 244 50 at at IN cord-320959-sgdqhtns 244 51 domain domain NN cord-320959-sgdqhtns 244 52 boundaries boundary NNS cord-320959-sgdqhtns 244 53 in in IN cord-320959-sgdqhtns 244 54 model model NN cord-320959-sgdqhtns 244 55 membranes membrane NNS cord-320959-sgdqhtns 244 56 Modulation modulation NN cord-320959-sgdqhtns 244 57 of of IN cord-320959-sgdqhtns 244 58 a a DT cord-320959-sgdqhtns 244 59 small small JJ cord-320959-sgdqhtns 244 60 two two CD cord-320959-sgdqhtns 244 61 - - HYPH cord-320959-sgdqhtns 244 62 domain domain NN cord-320959-sgdqhtns 244 63 lipid lipid NN cord-320959-sgdqhtns 244 64 vesicle vesicle NN cord-320959-sgdqhtns 244 65 by by IN cord-320959-sgdqhtns 244 66 Linactants Linactants NNP cord-320959-sgdqhtns 244 67 Physical Physical NNP cord-320959-sgdqhtns 244 68 properties property NNS cord-320959-sgdqhtns 244 69 of of IN cord-320959-sgdqhtns 244 70 the the DT cord-320959-sgdqhtns 244 71 hybrid hybrid JJ cord-320959-sgdqhtns 244 72 lipid lipid NN cord-320959-sgdqhtns 244 73 POPC POPC NNP cord-320959-sgdqhtns 244 74 on on IN cord-320959-sgdqhtns 244 75 micrometer micrometer NN cord-320959-sgdqhtns 244 76 - - HYPH cord-320959-sgdqhtns 244 77 sized sized JJ cord-320959-sgdqhtns 244 78 domains domain NNS cord-320959-sgdqhtns 244 79 in in IN cord-320959-sgdqhtns 244 80 mixed mixed JJ cord-320959-sgdqhtns 244 81 lipid lipid NN cord-320959-sgdqhtns 244 82 membranes membrane NNS cord-320959-sgdqhtns 244 83 Insights insight NNS cord-320959-sgdqhtns 244 84 into into IN cord-320959-sgdqhtns 244 85 the the DT cord-320959-sgdqhtns 244 86 dynamics dynamic NNS cord-320959-sgdqhtns 244 87 of of IN cord-320959-sgdqhtns 244 88 DMSO DMSO NNP cord-320959-sgdqhtns 244 89 in in IN cord-320959-sgdqhtns 244 90 phosphatidylcholine phosphatidylcholine NN cord-320959-sgdqhtns 244 91 bilayers bilayer NNS cord-320959-sgdqhtns 245 1 ENaC enac JJ cord-320959-sgdqhtns 245 2 activity activity NN cord-320959-sgdqhtns 245 3 and and CC cord-320959-sgdqhtns 245 4 expression expression NN cord-320959-sgdqhtns 245 5 is be VBZ cord-320959-sgdqhtns 245 6 decreased decrease VBN cord-320959-sgdqhtns 245 7 in in IN cord-320959-sgdqhtns 245 8 the the DT cord-320959-sgdqhtns 245 9 lungs lung NNS cord-320959-sgdqhtns 245 10 of of IN cord-320959-sgdqhtns 245 11 protein protein NN cord-320959-sgdqhtns 245 12 kinase kinase NN cord-320959-sgdqhtns 245 13 C C NNP cord-320959-sgdqhtns 245 14 - - HYPH cord-320959-sgdqhtns 245 15 α α NN cord-320959-sgdqhtns 245 16 knockout knockout NN cord-320959-sgdqhtns 245 17 mice mouse NNS cord-320959-sgdqhtns 245 18 Pregnane Pregnane NNP cord-320959-sgdqhtns 245 19 X X NNP cord-320959-sgdqhtns 245 20 Receptor Receptor NNP cord-320959-sgdqhtns 245 21 Knockout Knockout NNP cord-320959-sgdqhtns 246 1 Mice mice NN cord-320959-sgdqhtns 246 2 Display display NN cord-320959-sgdqhtns 247 1 Aging age VBG cord-320959-sgdqhtns 247 2 - - HYPH cord-320959-sgdqhtns 247 3 Dependent dependent JJ cord-320959-sgdqhtns 247 4 Wearing wear VBG cord-320959-sgdqhtns 247 5 of of IN cord-320959-sgdqhtns 247 6 Articular Articular NNP cord-320959-sgdqhtns 247 7 Cartilage Cartilage NNP cord-320959-sgdqhtns 247 8 Clinical clinical JJ cord-320959-sgdqhtns 247 9 features feature NNS cord-320959-sgdqhtns 247 10 of of IN cord-320959-sgdqhtns 247 11 patients patient NNS cord-320959-sgdqhtns 247 12 infected infect VBN cord-320959-sgdqhtns 247 13 with with IN cord-320959-sgdqhtns 247 14 2019 2019 CD cord-320959-sgdqhtns 247 15 novel novel JJ cord-320959-sgdqhtns 247 16 coronavirus coronavirus NN cord-320959-sgdqhtns 247 17 in in IN cord-320959-sgdqhtns 247 18 Wuhan Wuhan NNP cord-320959-sgdqhtns 248 1 , , , cord-320959-sgdqhtns 248 2 China China NNP cord-320959-sgdqhtns 248 3 Notes Notes NNPS cord-320959-sgdqhtns 248 4 from from IN cord-320959-sgdqhtns 248 5 the the DT cord-320959-sgdqhtns 248 6 Field field NN cord-320959-sgdqhtns 248 7 : : : cord-320959-sgdqhtns 248 8 E e NN cord-320959-sgdqhtns 248 9 - - NN cord-320959-sgdqhtns 248 10 cigarette cigarette NN cord-320959-sgdqhtns 248 11 , , , cord-320959-sgdqhtns 248 12 or or CC cord-320959-sgdqhtns 248 13 Vaping vaping NN cord-320959-sgdqhtns 248 14 , , , cord-320959-sgdqhtns 249 1 Product product NN cord-320959-sgdqhtns 249 2 Use use NN cord-320959-sgdqhtns 249 3 - - HYPH cord-320959-sgdqhtns 249 4 Associated Associated NNP cord-320959-sgdqhtns 249 5 Lung Lung NNP cord-320959-sgdqhtns 249 6 Injury injury NN cord-320959-sgdqhtns 249 7 Cases case NNS cord-320959-sgdqhtns 249 8 During during IN cord-320959-sgdqhtns 249 9 the the DT cord-320959-sgdqhtns 249 10 COVID-19 COVID-19 NNP cord-320959-sgdqhtns 249 11 Response Response NNP cord-320959-sgdqhtns 249 12 -California -California VBZ cord-320959-sgdqhtns 249 13 Commercial commercial JJ cord-320959-sgdqhtns 249 14 versus versus IN cord-320959-sgdqhtns 249 15 native native JJ cord-320959-sgdqhtns 249 16 surfactants surfactant NNS cord-320959-sgdqhtns 249 17 : : : cord-320959-sgdqhtns 249 18 Surface surface NN cord-320959-sgdqhtns 249 19 activity activity NN cord-320959-sgdqhtns 249 20 , , , cord-320959-sgdqhtns 249 21 molecular molecular JJ cord-320959-sgdqhtns 249 22 components component NNS cord-320959-sgdqhtns 249 23 , , , cord-320959-sgdqhtns 249 24 and and CC cord-320959-sgdqhtns 249 25 the the DT cord-320959-sgdqhtns 249 26 effect effect NN cord-320959-sgdqhtns 249 27 of of IN cord-320959-sgdqhtns 249 28 20 20 CD cord-320959-sgdqhtns 249 29 calcium calcium NN cord-320959-sgdqhtns 249 30 Themodynamics themodynamic NNS cord-320959-sgdqhtns 249 31 of of IN cord-320959-sgdqhtns 249 32 high high JJ cord-320959-sgdqhtns 249 33 polymer polymer NN cord-320959-sgdqhtns 249 34 solutions solution NNS cord-320959-sgdqhtns 249 35 Solutions Solutions NNPS cord-320959-sgdqhtns 249 36 of of IN cord-320959-sgdqhtns 249 37 long long JJ cord-320959-sgdqhtns 249 38 chain chain NN cord-320959-sgdqhtns 249 39 compounds compound NNS cord-320959-sgdqhtns 250 1 Controlled control VBN cord-320959-sgdqhtns 250 2 hypothermia hypothermia NN cord-320959-sgdqhtns 250 3 may may MD cord-320959-sgdqhtns 250 4 improve improve VB cord-320959-sgdqhtns 250 5 Kim Kim NNP cord-320959-sgdqhtns 250 6 at at IN cord-320959-sgdqhtns 250 7 the the DT cord-320959-sgdqhtns 250 8 Republic Republic NNP cord-320959-sgdqhtns 250 9 of of IN cord-320959-sgdqhtns 250 10 Korea Korea NNP cord-320959-sgdqhtns 250 11 Army Army NNP cord-320959-sgdqhtns 250 12 for for IN cord-320959-sgdqhtns 250 13 their -PRON- PRP$ cord-320959-sgdqhtns 250 14 administrative administrative JJ cord-320959-sgdqhtns 250 15 assistance assistance NN cord-320959-sgdqhtns 250 16 . . .