id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257558-dgnbfzli	Diamond, Betty	The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications	2020-06-18		.txt	text/plain	1414	84	56	ACE2 cleaves angiotensin II to produce a small peptide, ang1-7, which binds to a G protein-coupled receptor Mas to induce an anti-inflammatory and anti-apoptotic program and vasodilation (Simões e Silva et al., 2013) . When the viral spike protein binds ACE2, however, another protease termed TACE, or ADAM 17, is activated; this causes ACE2 to be shed from the cell membrane, leading to decreased degradation of angiotensin II and decreased production of ang1-7 (Shah and Catt, 2006) . A model of COVID-19 might be that SARS-CoV-2 infects lung alveolar epithelial cells, the source of surfactant, causing a cytopathic effect. First, COVID-19 patients will have a high level of angiotensin II, perhaps even African Americans, and a low level of ang1-7 due to the diminished activity of ACE2. Right: In a SARS-CoV-2-infected individual, there is an imbalanced RAS, with viral spike protein causing ACE2 shedding, diminished production of ang1-7, and high AT1 with low AT2.	./cache/cord-257558-dgnbfzli.txt	./txt/cord-257558-dgnbfzli.txt