id	sid	tid	token	lemma	pos
cord-006439-q7m4srvp	1	1	key	key	NN
cord-006439-q7m4srvp	1	2	:	:	:
cord-006439-q7m4srvp	1	3	cord-006439-q7m4srvp	cord-006439-q7m4srvp	NNP
cord-006439-q7m4srvp	1	4	authors	author	NNS
cord-006439-q7m4srvp	1	5	:	:	:
cord-006439-q7m4srvp	1	6	Nakagawa	Nakagawa	NNP
cord-006439-q7m4srvp	1	7	,	,	,
cord-006439-q7m4srvp	1	8	Pablo	Pablo	NNP
cord-006439-q7m4srvp	1	9	;	;	:
cord-006439-q7m4srvp	1	10	Gomez	Gomez	NNP
cord-006439-q7m4srvp	1	11	,	,	,
cord-006439-q7m4srvp	1	12	Javier	Javier	NNP
cord-006439-q7m4srvp	1	13	;	;	:
cord-006439-q7m4srvp	1	14	Grobe	Grobe	NNP
cord-006439-q7m4srvp	1	15	,	,	,
cord-006439-q7m4srvp	1	16	Justin	Justin	NNP
cord-006439-q7m4srvp	1	17	L.	L.	NNP
cord-006439-q7m4srvp	1	18	;	;	:
cord-006439-q7m4srvp	1	19	Sigmund	Sigmund	NNP
cord-006439-q7m4srvp	1	20	,	,	,
cord-006439-q7m4srvp	1	21	Curt	Curt	NNP
cord-006439-q7m4srvp	1	22	D.	D.	NNP
cord-006439-q7m4srvp	1	23	title	title	NN
cord-006439-q7m4srvp	1	24	:	:	:
cord-006439-q7m4srvp	1	25	The	the	DT
cord-006439-q7m4srvp	1	26	Renin	Renin	NNP
cord-006439-q7m4srvp	1	27	-	-	HYPH
cord-006439-q7m4srvp	1	28	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	1	29	System	System	NNP
cord-006439-q7m4srvp	1	30	in	in	IN
cord-006439-q7m4srvp	1	31	the	the	DT
cord-006439-q7m4srvp	1	32	Central	Central	NNP
cord-006439-q7m4srvp	1	33	Nervous	Nervous	NNP
cord-006439-q7m4srvp	1	34	System	System	NNP
cord-006439-q7m4srvp	1	35	and	and	CC
cord-006439-q7m4srvp	1	36	Its	-PRON-	PRP$
cord-006439-q7m4srvp	1	37	Role	role	NN
cord-006439-q7m4srvp	1	38	in	in	IN
cord-006439-q7m4srvp	1	39	Blood	Blood	NNP
cord-006439-q7m4srvp	1	40	Pressure	Pressure	NNP
cord-006439-q7m4srvp	1	41	Regulation	Regulation	NNP
cord-006439-q7m4srvp	1	42	date	date	NN
cord-006439-q7m4srvp	1	43	:	:	:
cord-006439-q7m4srvp	1	44	2020	2020	CD
cord-006439-q7m4srvp	1	45	-	-	HYPH
cord-006439-q7m4srvp	1	46	01	01	CD
cord-006439-q7m4srvp	1	47	-	-	SYM
cord-006439-q7m4srvp	1	48	10	10	CD
cord-006439-q7m4srvp	1	49	journal	journal	NN
cord-006439-q7m4srvp	1	50	:	:	:
cord-006439-q7m4srvp	2	1	Curr	Curr	NNP
cord-006439-q7m4srvp	2	2	Hypertens	Hypertens	NNP
cord-006439-q7m4srvp	2	3	Rep	Rep	NNP
cord-006439-q7m4srvp	2	4	DOI	DOI	NNP
cord-006439-q7m4srvp	2	5	:	:	:
cord-006439-q7m4srvp	3	1	10.1007	10.1007	CD
cord-006439-q7m4srvp	3	2	/	/	SYM
cord-006439-q7m4srvp	3	3	s11906	s11906	NNP
cord-006439-q7m4srvp	3	4	-	-	HYPH
cord-006439-q7m4srvp	3	5	019	019	CD
cord-006439-q7m4srvp	3	6	-	-	HYPH
cord-006439-q7m4srvp	3	7	1011	1011	CD
cord-006439-q7m4srvp	3	8	-	-	SYM
cord-006439-q7m4srvp	3	9	2	2	CD
cord-006439-q7m4srvp	3	10	sha	sha	NN
cord-006439-q7m4srvp	3	11	:	:	:
cord-006439-q7m4srvp	3	12	0fcc3896445a8ac9bab74697da1081e8fa1c6279	0fcc3896445a8ac9bab74697da1081e8fa1c6279	CD
cord-006439-q7m4srvp	3	13	doc_id	doc_id	CD
cord-006439-q7m4srvp	4	1	:	:	:
cord-006439-q7m4srvp	4	2	6439	6439	CD
cord-006439-q7m4srvp	4	3	cord_uid	cord_uid	NN
cord-006439-q7m4srvp	4	4	:	:	:
cord-006439-q7m4srvp	5	1	q7m4srvp	q7m4srvp	NFP
cord-006439-q7m4srvp	5	2	PURPOSE	purpose	NN
cord-006439-q7m4srvp	5	3	OF	of	IN
cord-006439-q7m4srvp	5	4	THE	the	DT
cord-006439-q7m4srvp	5	5	REVIEW	review	NN
cord-006439-q7m4srvp	5	6	:	:	:
cord-006439-q7m4srvp	6	1	The	the	DT
cord-006439-q7m4srvp	6	2	main	main	JJ
cord-006439-q7m4srvp	6	3	goal	goal	NN
cord-006439-q7m4srvp	6	4	of	of	IN
cord-006439-q7m4srvp	6	5	this	this	DT
cord-006439-q7m4srvp	6	6	article	article	NN
cord-006439-q7m4srvp	6	7	is	be	VBZ
cord-006439-q7m4srvp	6	8	to	to	TO
cord-006439-q7m4srvp	6	9	discuss	discuss	VB
cord-006439-q7m4srvp	6	10	how	how	WRB
cord-006439-q7m4srvp	6	11	the	the	DT
cord-006439-q7m4srvp	6	12	development	development	NN
cord-006439-q7m4srvp	6	13	of	of	IN
cord-006439-q7m4srvp	6	14	state	state	NN
cord-006439-q7m4srvp	6	15	-	-	HYPH
cord-006439-q7m4srvp	6	16	of	of	IN
cord-006439-q7m4srvp	6	17	-	-	HYPH
cord-006439-q7m4srvp	6	18	the	the	DT
cord-006439-q7m4srvp	6	19	-	-	HYPH
cord-006439-q7m4srvp	6	20	art	art	NN
cord-006439-q7m4srvp	6	21	technology	technology	NN
cord-006439-q7m4srvp	6	22	has	have	VBZ
cord-006439-q7m4srvp	6	23	made	make	VBN
cord-006439-q7m4srvp	6	24	it	-PRON-	PRP
cord-006439-q7m4srvp	6	25	possible	possible	JJ
cord-006439-q7m4srvp	6	26	to	to	TO
cord-006439-q7m4srvp	6	27	address	address	VB
cord-006439-q7m4srvp	6	28	fundamental	fundamental	JJ
cord-006439-q7m4srvp	6	29	questions	question	NNS
cord-006439-q7m4srvp	6	30	related	relate	VBN
cord-006439-q7m4srvp	6	31	to	to	IN
cord-006439-q7m4srvp	6	32	how	how	WRB
cord-006439-q7m4srvp	6	33	the	the	DT
cord-006439-q7m4srvp	6	34	renin	renin	NN
cord-006439-q7m4srvp	6	35	-	-	HYPH
cord-006439-q7m4srvp	6	36	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	6	37	system	system	NN
cord-006439-q7m4srvp	6	38	(	(	-LRB-
cord-006439-q7m4srvp	6	39	RAS	RAS	NNP
cord-006439-q7m4srvp	6	40	)	)	-RRB-
cord-006439-q7m4srvp	6	41	operates	operate	VBZ
cord-006439-q7m4srvp	6	42	within	within	IN
cord-006439-q7m4srvp	6	43	the	the	DT
cord-006439-q7m4srvp	6	44	brain	brain	NN
cord-006439-q7m4srvp	6	45	from	from	IN
cord-006439-q7m4srvp	6	46	the	the	DT
cord-006439-q7m4srvp	6	47	neurophysiological	neurophysiological	JJ
cord-006439-q7m4srvp	6	48	and	and	CC
cord-006439-q7m4srvp	6	49	molecular	molecular	JJ
cord-006439-q7m4srvp	6	50	perspective	perspective	NN
cord-006439-q7m4srvp	6	51	.	.	.
cord-006439-q7m4srvp	7	1	RECENT	recent	JJ
cord-006439-q7m4srvp	7	2	FINDINGS	finding	NNS
cord-006439-q7m4srvp	7	3	:	:	:
cord-006439-q7m4srvp	8	1	The	the	DT
cord-006439-q7m4srvp	8	2	existence	existence	NN
cord-006439-q7m4srvp	8	3	of	of	IN
cord-006439-q7m4srvp	8	4	the	the	DT
cord-006439-q7m4srvp	8	5	brain	brain	NN
cord-006439-q7m4srvp	8	6	RAS	RAS	NNP
cord-006439-q7m4srvp	8	7	remains	remain	VBZ
cord-006439-q7m4srvp	8	8	surprisingly	surprisingly	RB
cord-006439-q7m4srvp	8	9	controversial	controversial	JJ
cord-006439-q7m4srvp	8	10	.	.	.
cord-006439-q7m4srvp	9	1	New	new	JJ
cord-006439-q7m4srvp	9	2	sensitive	sensitive	JJ
cord-006439-q7m4srvp	9	3	in	in	IN
cord-006439-q7m4srvp	9	4	situ	situ	JJ
cord-006439-q7m4srvp	9	5	hybridization	hybridization	NN
cord-006439-q7m4srvp	9	6	techniques	technique	NNS
cord-006439-q7m4srvp	9	7	and	and	CC
cord-006439-q7m4srvp	9	8	novel	novel	JJ
cord-006439-q7m4srvp	9	9	transgenic	transgenic	JJ
cord-006439-q7m4srvp	9	10	animals	animal	NNS
cord-006439-q7m4srvp	9	11	expressing	express	VBG
cord-006439-q7m4srvp	9	12	reporter	reporter	NN
cord-006439-q7m4srvp	9	13	genes	gene	NNS
cord-006439-q7m4srvp	9	14	have	have	VBP
cord-006439-q7m4srvp	9	15	provided	provide	VBN
cord-006439-q7m4srvp	9	16	pivotal	pivotal	JJ
cord-006439-q7m4srvp	9	17	information	information	NN
cord-006439-q7m4srvp	9	18	of	of	IN
cord-006439-q7m4srvp	9	19	the	the	DT
cord-006439-q7m4srvp	9	20	expression	expression	NN
cord-006439-q7m4srvp	9	21	of	of	IN
cord-006439-q7m4srvp	9	22	RAS	RAS	NNP
cord-006439-q7m4srvp	9	23	genes	gene	NNS
cord-006439-q7m4srvp	9	24	within	within	IN
cord-006439-q7m4srvp	9	25	the	the	DT
cord-006439-q7m4srvp	9	26	brain	brain	NN
cord-006439-q7m4srvp	9	27	.	.	.
cord-006439-q7m4srvp	10	1	We	-PRON-	PRP
cord-006439-q7m4srvp	10	2	discuss	discuss	VBP
cord-006439-q7m4srvp	10	3	studies	study	NNS
cord-006439-q7m4srvp	10	4	using	use	VBG
cord-006439-q7m4srvp	10	5	genetically	genetically	RB
cord-006439-q7m4srvp	10	6	engineered	engineer	VBN
cord-006439-q7m4srvp	10	7	animals	animal	NNS
cord-006439-q7m4srvp	10	8	combined	combine	VBN
cord-006439-q7m4srvp	10	9	with	with	IN
cord-006439-q7m4srvp	10	10	targeted	target	VBN
cord-006439-q7m4srvp	10	11	viral	viral	JJ
cord-006439-q7m4srvp	10	12	microinjections	microinjection	NNS
cord-006439-q7m4srvp	10	13	to	to	TO
cord-006439-q7m4srvp	10	14	study	study	VB
cord-006439-q7m4srvp	10	15	molecular	molecular	JJ
cord-006439-q7m4srvp	10	16	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	10	17	implicated	implicate	VBN
cord-006439-q7m4srvp	10	18	in	in	IN
cord-006439-q7m4srvp	10	19	the	the	DT
cord-006439-q7m4srvp	10	20	regulation	regulation	NN
cord-006439-q7m4srvp	10	21	of	of	IN
cord-006439-q7m4srvp	10	22	the	the	DT
cord-006439-q7m4srvp	10	23	brain	brain	NN
cord-006439-q7m4srvp	10	24	RAS	RAS	NNP
cord-006439-q7m4srvp	10	25	.	.	.
cord-006439-q7m4srvp	11	1	We	-PRON-	PRP
cord-006439-q7m4srvp	11	2	also	also	RB
cord-006439-q7m4srvp	11	3	discuss	discuss	VBP
cord-006439-q7m4srvp	11	4	novel	novel	JJ
cord-006439-q7m4srvp	11	5	drugs	drug	NNS
cord-006439-q7m4srvp	11	6	targeting	target	VBG
cord-006439-q7m4srvp	11	7	the	the	DT
cord-006439-q7m4srvp	11	8	brain	brain	NN
cord-006439-q7m4srvp	11	9	RAS	RAS	NNP
cord-006439-q7m4srvp	11	10	that	that	WDT
cord-006439-q7m4srvp	11	11	have	have	VBP
cord-006439-q7m4srvp	11	12	shown	show	VBN
cord-006439-q7m4srvp	11	13	promising	promising	JJ
cord-006439-q7m4srvp	11	14	results	result	NNS
cord-006439-q7m4srvp	11	15	in	in	IN
cord-006439-q7m4srvp	11	16	clinical	clinical	JJ
cord-006439-q7m4srvp	11	17	studies	study	NNS
cord-006439-q7m4srvp	11	18	and	and	CC
cord-006439-q7m4srvp	11	19	trials	trial	NNS
cord-006439-q7m4srvp	11	20	.	.	.
cord-006439-q7m4srvp	12	1	SUMMARY	summary	NN
cord-006439-q7m4srvp	12	2	:	:	:
cord-006439-q7m4srvp	13	1	Over	over	IN
cord-006439-q7m4srvp	13	2	the	the	DT
cord-006439-q7m4srvp	13	3	last	last	JJ
cord-006439-q7m4srvp	13	4	50	50	CD
cord-006439-q7m4srvp	13	5	years	year	NNS
cord-006439-q7m4srvp	13	6	,	,	,
cord-006439-q7m4srvp	13	7	several	several	JJ
cord-006439-q7m4srvp	13	8	new	new	JJ
cord-006439-q7m4srvp	13	9	physiological	physiological	JJ
cord-006439-q7m4srvp	13	10	roles	role	NNS
cord-006439-q7m4srvp	13	11	of	of	IN
cord-006439-q7m4srvp	13	12	the	the	DT
cord-006439-q7m4srvp	13	13	brain	brain	NN
cord-006439-q7m4srvp	13	14	RAS	RAS	NNP
cord-006439-q7m4srvp	13	15	have	have	VBP
cord-006439-q7m4srvp	13	16	been	be	VBN
cord-006439-q7m4srvp	13	17	identified	identify	VBN
cord-006439-q7m4srvp	13	18	.	.	.
cord-006439-q7m4srvp	14	1	In	in	IN
cord-006439-q7m4srvp	14	2	the	the	DT
cord-006439-q7m4srvp	14	3	coming	come	VBG
cord-006439-q7m4srvp	14	4	years	year	NNS
cord-006439-q7m4srvp	14	5	,	,	,
cord-006439-q7m4srvp	14	6	efforts	effort	NNS
cord-006439-q7m4srvp	14	7	to	to	TO
cord-006439-q7m4srvp	14	8	incorporate	incorporate	VB
cord-006439-q7m4srvp	14	9	cutting	cut	VBG
cord-006439-q7m4srvp	14	10	-	-	HYPH
cord-006439-q7m4srvp	14	11	edge	edge	NN
cord-006439-q7m4srvp	14	12	technologies	technology	NNS
cord-006439-q7m4srvp	14	13	such	such	JJ
cord-006439-q7m4srvp	14	14	as	as	IN
cord-006439-q7m4srvp	14	15	optogenetics	optogenetics	NN
cord-006439-q7m4srvp	14	16	,	,	,
cord-006439-q7m4srvp	14	17	chemogenetics	chemogenetics	NNP
cord-006439-q7m4srvp	14	18	,	,	,
cord-006439-q7m4srvp	14	19	and	and	CC
cord-006439-q7m4srvp	14	20	single	single	JJ
cord-006439-q7m4srvp	14	21	-	-	HYPH
cord-006439-q7m4srvp	14	22	cell	cell	NN
cord-006439-q7m4srvp	14	23	RNA	RNA	NNP
cord-006439-q7m4srvp	14	24	sequencing	sequencing	NN
cord-006439-q7m4srvp	14	25	will	will	MD
cord-006439-q7m4srvp	14	26	lead	lead	VB
cord-006439-q7m4srvp	14	27	to	to	IN
cord-006439-q7m4srvp	14	28	dramatic	dramatic	JJ
cord-006439-q7m4srvp	14	29	advances	advance	NNS
cord-006439-q7m4srvp	14	30	in	in	IN
cord-006439-q7m4srvp	14	31	our	-PRON-	PRP$
cord-006439-q7m4srvp	14	32	full	full	JJ
cord-006439-q7m4srvp	14	33	understanding	understanding	NN
cord-006439-q7m4srvp	14	34	of	of	IN
cord-006439-q7m4srvp	14	35	how	how	WRB
cord-006439-q7m4srvp	14	36	the	the	DT
cord-006439-q7m4srvp	14	37	brain	brain	NN
cord-006439-q7m4srvp	14	38	RAS	RAS	NNP
cord-006439-q7m4srvp	14	39	operates	operate	VBZ
cord-006439-q7m4srvp	14	40	at	at	IN
cord-006439-q7m4srvp	14	41	molecular	molecular	JJ
cord-006439-q7m4srvp	14	42	and	and	CC
cord-006439-q7m4srvp	14	43	neurophysiological	neurophysiological	JJ
cord-006439-q7m4srvp	14	44	levels	level	NNS
cord-006439-q7m4srvp	14	45	.	.	.
cord-006439-q7m4srvp	15	1	The	the	DT
cord-006439-q7m4srvp	15	2	physiological	physiological	JJ
cord-006439-q7m4srvp	15	3	relevance	relevance	NN
cord-006439-q7m4srvp	15	4	of	of	IN
cord-006439-q7m4srvp	15	5	the	the	DT
cord-006439-q7m4srvp	15	6	renin	renin	NN
cord-006439-q7m4srvp	15	7	angiotensin	angiotensin	NNP
cord-006439-q7m4srvp	15	8	system	system	NN
cord-006439-q7m4srvp	15	9	(	(	-LRB-
cord-006439-q7m4srvp	15	10	RAS	RAS	NNP
cord-006439-q7m4srvp	15	11	)	)	-RRB-
cord-006439-q7m4srvp	15	12	in	in	IN
cord-006439-q7m4srvp	15	13	blood	blood	NN
cord-006439-q7m4srvp	15	14	pressure	pressure	NN
cord-006439-q7m4srvp	15	15	regulation	regulation	NN
cord-006439-q7m4srvp	15	16	and	and	CC
cord-006439-q7m4srvp	15	17	electrolyte	electrolyte	NN
cord-006439-q7m4srvp	15	18	homeostasis	homeostasis	NN
cord-006439-q7m4srvp	15	19	is	be	VBZ
cord-006439-q7m4srvp	15	20	well	well	RB
cord-006439-q7m4srvp	15	21	established	established	JJ
cord-006439-q7m4srvp	15	22	and	and	CC
cord-006439-q7m4srvp	15	23	undisputable	undisputable	JJ
cord-006439-q7m4srvp	15	24	.	.	.
cord-006439-q7m4srvp	16	1	The	the	DT
cord-006439-q7m4srvp	16	2	RAS	RAS	NNP
cord-006439-q7m4srvp	16	3	is	be	VBZ
cord-006439-q7m4srvp	16	4	traditionally	traditionally	RB
cord-006439-q7m4srvp	16	5	described	describe	VBN
cord-006439-q7m4srvp	16	6	as	as	IN
cord-006439-q7m4srvp	16	7	a	a	DT
cord-006439-q7m4srvp	16	8	hormone	hormone	NN
cord-006439-q7m4srvp	16	9	system	system	NN
cord-006439-q7m4srvp	16	10	,	,	,
cord-006439-q7m4srvp	16	11	which	which	WDT
cord-006439-q7m4srvp	16	12	promotes	promote	VBZ
cord-006439-q7m4srvp	16	13	arterial	arterial	JJ
cord-006439-q7m4srvp	16	14	blood	blood	NN
cord-006439-q7m4srvp	16	15	pressure	pressure	NN
cord-006439-q7m4srvp	16	16	elevation	elevation	NN
cord-006439-q7m4srvp	16	17	primarily	primarily	RB
cord-006439-q7m4srvp	16	18	by	by	IN
cord-006439-q7m4srvp	16	19	inducing	induce	VBG
cord-006439-q7m4srvp	16	20	vasoconstriction	vasoconstriction	NN
cord-006439-q7m4srvp	16	21	,	,	,
cord-006439-q7m4srvp	16	22	sodium	sodium	NN
cord-006439-q7m4srvp	16	23	retention	retention	NN
cord-006439-q7m4srvp	16	24	,	,	,
cord-006439-q7m4srvp	16	25	and	and	CC
cord-006439-q7m4srvp	16	26	aldosterone	aldosterone	NN
cord-006439-q7m4srvp	16	27	release	release	NN
cord-006439-q7m4srvp	16	28	.	.	.
cord-006439-q7m4srvp	17	1	The	the	DT
cord-006439-q7m4srvp	17	2	sustained	sustained	JJ
cord-006439-q7m4srvp	17	3	overactivation	overactivation	NN
cord-006439-q7m4srvp	17	4	of	of	IN
cord-006439-q7m4srvp	17	5	the	the	DT
cord-006439-q7m4srvp	17	6	RAS	RAS	NNP
cord-006439-q7m4srvp	17	7	could	could	MD
cord-006439-q7m4srvp	17	8	lead	lead	VB
cord-006439-q7m4srvp	17	9	to	to	IN
cord-006439-q7m4srvp	17	10	hypertension	hypertension	NN
cord-006439-q7m4srvp	17	11	,	,	,
cord-006439-q7m4srvp	17	12	a	a	DT
cord-006439-q7m4srvp	17	13	disease	disease	NN
cord-006439-q7m4srvp	17	14	affecting	affect	VBG
cord-006439-q7m4srvp	17	15	almost	almost	RB
cord-006439-q7m4srvp	17	16	half	half	NN
cord-006439-q7m4srvp	17	17	of	of	IN
cord-006439-q7m4srvp	17	18	US	US	NNP
cord-006439-q7m4srvp	17	19	American	american	JJ
cord-006439-q7m4srvp	17	20	adults	adult	NNS
cord-006439-q7m4srvp	17	21	[	[	-LRB-
cord-006439-q7m4srvp	17	22	1	1	CD
cord-006439-q7m4srvp	17	23	]	]	-RRB-
cord-006439-q7m4srvp	17	24	.	.	.
cord-006439-q7m4srvp	18	1	The	the	DT
cord-006439-q7m4srvp	18	2	activation	activation	NN
cord-006439-q7m4srvp	18	3	of	of	IN
cord-006439-q7m4srvp	18	4	the	the	DT
cord-006439-q7m4srvp	18	5	endocrine	endocrine	JJ
cord-006439-q7m4srvp	18	6	RAS	RAS	NNP
cord-006439-q7m4srvp	18	7	is	be	VBZ
cord-006439-q7m4srvp	18	8	initiated	initiate	VBN
cord-006439-q7m4srvp	18	9	upon	upon	IN
cord-006439-q7m4srvp	18	10	the	the	DT
cord-006439-q7m4srvp	18	11	release	release	NN
cord-006439-q7m4srvp	18	12	of	of	IN
cord-006439-q7m4srvp	18	13	renin	renin	NN
cord-006439-q7m4srvp	18	14	from	from	IN
cord-006439-q7m4srvp	18	15	juxtaglomerular	juxtaglomerular	JJ
cord-006439-q7m4srvp	18	16	cell	cell	NN
cord-006439-q7m4srvp	18	17	granules	granule	NNS
cord-006439-q7m4srvp	18	18	into	into	IN
cord-006439-q7m4srvp	18	19	the	the	DT
cord-006439-q7m4srvp	18	20	circulation	circulation	NN
cord-006439-q7m4srvp	18	21	.	.	.
cord-006439-q7m4srvp	19	1	By	by	IN
cord-006439-q7m4srvp	19	2	catalyzing	catalyze	VBG
cord-006439-q7m4srvp	19	3	the	the	DT
cord-006439-q7m4srvp	19	4	cleavage	cleavage	NN
cord-006439-q7m4srvp	19	5	of	of	IN
cord-006439-q7m4srvp	19	6	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	19	7	to	to	TO
cord-006439-q7m4srvp	19	8	release	release	VB
cord-006439-q7m4srvp	19	9	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	20	1	I	-PRON-	PRP
cord-006439-q7m4srvp	20	2	peptide	peptide	NN
cord-006439-q7m4srvp	20	3	,	,	,
cord-006439-q7m4srvp	20	4	renin	renin	NN
cord-006439-q7m4srvp	20	5	acts	act	NNS
cord-006439-q7m4srvp	20	6	as	as	IN
cord-006439-q7m4srvp	20	7	the	the	DT
cord-006439-q7m4srvp	20	8	rate	rate	NN
cord-006439-q7m4srvp	20	9	limiting	limit	VBG
cord-006439-q7m4srvp	20	10	enzyme	enzyme	NN
cord-006439-q7m4srvp	20	11	of	of	IN
cord-006439-q7m4srvp	20	12	the	the	DT
cord-006439-q7m4srvp	20	13	RAS	RAS	NNP
cord-006439-q7m4srvp	20	14	,	,	,
cord-006439-q7m4srvp	20	15	at	at	IN
cord-006439-q7m4srvp	20	16	least	least	JJS
cord-006439-q7m4srvp	20	17	in	in	IN
cord-006439-q7m4srvp	20	18	humans	human	NNS
cord-006439-q7m4srvp	20	19	.	.	.
cord-006439-q7m4srvp	21	1	Thus	thus	RB
cord-006439-q7m4srvp	21	2	,	,	,
cord-006439-q7m4srvp	21	3	it	-PRON-	PRP
cord-006439-q7m4srvp	21	4	is	be	VBZ
cord-006439-q7m4srvp	21	5	not	not	RB
cord-006439-q7m4srvp	21	6	surprising	surprising	JJ
cord-006439-q7m4srvp	21	7	that	that	IN
cord-006439-q7m4srvp	21	8	there	there	EX
cord-006439-q7m4srvp	21	9	are	be	VBP
cord-006439-q7m4srvp	21	10	a	a	DT
cord-006439-q7m4srvp	21	11	number	number	NN
cord-006439-q7m4srvp	21	12	of	of	IN
cord-006439-q7m4srvp	21	13	complex	complex	JJ
cord-006439-q7m4srvp	21	14	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	21	15	regulating	regulate	VBG
cord-006439-q7m4srvp	21	16	renin	renin	NN
cord-006439-q7m4srvp	21	17	expression	expression	NN
cord-006439-q7m4srvp	21	18	and	and	CC
cord-006439-q7m4srvp	21	19	secretion	secretion	NN
cord-006439-q7m4srvp	21	20	[	[	-LRB-
cord-006439-q7m4srvp	21	21	2	2	CD
cord-006439-q7m4srvp	21	22	]	]	-RRB-
cord-006439-q7m4srvp	21	23	.	.	.
cord-006439-q7m4srvp	22	1	The	the	DT
cord-006439-q7m4srvp	22	2	subsequent	subsequent	JJ
cord-006439-q7m4srvp	22	3	conversion	conversion	NN
cord-006439-q7m4srvp	22	4	of	of	IN
cord-006439-q7m4srvp	22	5	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	22	6	(	(	-LRB-
cord-006439-q7m4srvp	22	7	ANG)-I	ANG)-I	NNP
cord-006439-q7m4srvp	22	8	to	to	IN
cord-006439-q7m4srvp	22	9	ANG	ANG	NNP
cord-006439-q7m4srvp	22	10	-	-	HYPH
cord-006439-q7m4srvp	22	11	II	II	NNP
cord-006439-q7m4srvp	22	12	is	be	VBZ
cord-006439-q7m4srvp	22	13	catalyzed	catalyze	VBN
cord-006439-q7m4srvp	22	14	by	by	IN
cord-006439-q7m4srvp	22	15	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	22	16	converting	convert	VBG
cord-006439-q7m4srvp	22	17	enzyme	enzyme	NN
cord-006439-q7m4srvp	22	18	(	(	-LRB-
cord-006439-q7m4srvp	22	19	ACE	ACE	NNP
cord-006439-q7m4srvp	22	20	)	)	-RRB-
cord-006439-q7m4srvp	22	21	which	which	WDT
cord-006439-q7m4srvp	22	22	is	be	VBZ
cord-006439-q7m4srvp	22	23	localized	localize	VBN
cord-006439-q7m4srvp	22	24	to	to	IN
cord-006439-q7m4srvp	22	25	endothelial	endothelial	JJ
cord-006439-q7m4srvp	22	26	cells	cell	NNS
cord-006439-q7m4srvp	22	27	and	and	CC
cord-006439-q7m4srvp	22	28	is	be	VBZ
cord-006439-q7m4srvp	22	29	abundant	abundant	JJ
cord-006439-q7m4srvp	22	30	in	in	IN
cord-006439-q7m4srvp	22	31	the	the	DT
cord-006439-q7m4srvp	22	32	lungs	lung	NNS
cord-006439-q7m4srvp	22	33	.	.	.
cord-006439-q7m4srvp	23	1	Most	Most	JJS
cord-006439-q7m4srvp	23	2	of	of	IN
cord-006439-q7m4srvp	23	3	the	the	DT
cord-006439-q7m4srvp	23	4	functions	function	NNS
cord-006439-q7m4srvp	23	5	inducing	induce	VBG
cord-006439-q7m4srvp	23	6	blood	blood	NN
cord-006439-q7m4srvp	23	7	pressure	pressure	NN
cord-006439-q7m4srvp	23	8	elevation	elevation	NN
cord-006439-q7m4srvp	23	9	are	be	VBP
cord-006439-q7m4srvp	23	10	mediated	mediate	VBN
cord-006439-q7m4srvp	23	11	through	through	IN
cord-006439-q7m4srvp	23	12	binding	binding	NN
cord-006439-q7m4srvp	23	13	of	of	IN
cord-006439-q7m4srvp	23	14	ANG	ANG	NNP
cord-006439-q7m4srvp	23	15	-	-	HYPH
cord-006439-q7m4srvp	23	16	II	II	NNP
cord-006439-q7m4srvp	23	17	to	to	IN
cord-006439-q7m4srvp	23	18	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	23	19	type	type	NN
cord-006439-q7m4srvp	23	20	1	1	CD
cord-006439-q7m4srvp	23	21	receptor	receptor	NN
cord-006439-q7m4srvp	23	22	(	(	-LRB-
cord-006439-q7m4srvp	23	23	AT	at	IN
cord-006439-q7m4srvp	23	24	1	1	CD
cord-006439-q7m4srvp	23	25	R	r	NN
cord-006439-q7m4srvp	23	26	)	)	-RRB-
cord-006439-q7m4srvp	23	27	,	,	,
cord-006439-q7m4srvp	23	28	whereas	whereas	RB
cord-006439-q7m4srvp	23	29	,	,	,
cord-006439-q7m4srvp	23	30	binding	bind	VBG
cord-006439-q7m4srvp	23	31	of	of	IN
cord-006439-q7m4srvp	23	32	ANG	ANG	NNP
cord-006439-q7m4srvp	23	33	-	-	HYPH
cord-006439-q7m4srvp	23	34	II	II	NNP
cord-006439-q7m4srvp	23	35	to	to	IN
cord-006439-q7m4srvp	23	36	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	23	37	type	type	NN
cord-006439-q7m4srvp	23	38	II	II	NNP
cord-006439-q7m4srvp	23	39	receptors	receptor	NNS
cord-006439-q7m4srvp	23	40	(	(	-LRB-
cord-006439-q7m4srvp	23	41	AT	at	IN
cord-006439-q7m4srvp	23	42	2	2	CD
cord-006439-q7m4srvp	23	43	R	r	NN
cord-006439-q7m4srvp	23	44	)	)	-RRB-
cord-006439-q7m4srvp	23	45	has	have	VBZ
cord-006439-q7m4srvp	23	46	been	be	VBN
cord-006439-q7m4srvp	23	47	reported	report	VBN
cord-006439-q7m4srvp	23	48	to	to	TO
cord-006439-q7m4srvp	23	49	generally	generally	RB
cord-006439-q7m4srvp	23	50	oppose	oppose	VB
cord-006439-q7m4srvp	23	51	the	the	DT
cord-006439-q7m4srvp	23	52	actions	action	NNS
cord-006439-q7m4srvp	23	53	of	of	IN
cord-006439-q7m4srvp	23	54	AT	AT	NNP
cord-006439-q7m4srvp	23	55	1	1	CD
cord-006439-q7m4srvp	23	56	R.	R.	NNP
cord-006439-q7m4srvp	23	57	Other	other	JJ
cord-006439-q7m4srvp	23	58	peptides	peptide	NNS
cord-006439-q7m4srvp	23	59	of	of	IN
cord-006439-q7m4srvp	23	60	the	the	DT
cord-006439-q7m4srvp	23	61	RAS	RAS	NNP
cord-006439-q7m4srvp	23	62	,	,	,
cord-006439-q7m4srvp	23	63	such	such	JJ
cord-006439-q7m4srvp	23	64	as	as	IN
cord-006439-q7m4srvp	23	65	ANG-(1	ang-(1	CD
cord-006439-q7m4srvp	23	66	-	-	SYM
cord-006439-q7m4srvp	23	67	7	7	CD
cord-006439-q7m4srvp	23	68	)	)	-RRB-
cord-006439-q7m4srvp	23	69	and	and	CC
cord-006439-q7m4srvp	23	70	alamandine	alamandine	NNP
cord-006439-q7m4srvp	23	71	,	,	,
cord-006439-q7m4srvp	23	72	also	also	RB
cord-006439-q7m4srvp	23	73	act	act	VB
cord-006439-q7m4srvp	23	74	to	to	TO
cord-006439-q7m4srvp	23	75	counter	counter	VB
cord-006439-q7m4srvp	23	76	regulate	regulate	VB
cord-006439-q7m4srvp	23	77	the	the	DT
cord-006439-q7m4srvp	23	78	action	action	NN
cord-006439-q7m4srvp	23	79	of	of	IN
cord-006439-q7m4srvp	23	80	ANG	ANG	NNP
cord-006439-q7m4srvp	23	81	-	-	HYPH
cord-006439-q7m4srvp	23	82	II	II	NNP
cord-006439-q7m4srvp	23	83	at	at	IN
cord-006439-q7m4srvp	23	84	AT	at	NN
cord-006439-q7m4srvp	23	85	1	1	CD
cord-006439-q7m4srvp	23	86	R	r	NN
cord-006439-q7m4srvp	23	87	[	[	-LRB-
cord-006439-q7m4srvp	23	88	3	3	CD
cord-006439-q7m4srvp	23	89	,	,	,
cord-006439-q7m4srvp	23	90	4	4	CD
cord-006439-q7m4srvp	23	91	]	]	-RRB-
cord-006439-q7m4srvp	23	92	.	.	.
cord-006439-q7m4srvp	24	1	Drugs	drug	NNS
cord-006439-q7m4srvp	24	2	targeting	target	VBG
cord-006439-q7m4srvp	24	3	the	the	DT
cord-006439-q7m4srvp	24	4	RAS	RAS	NNP
cord-006439-q7m4srvp	24	5	are	be	VBP
cord-006439-q7m4srvp	24	6	effective	effective	JJ
cord-006439-q7m4srvp	24	7	as	as	IN
cord-006439-q7m4srvp	24	8	treatments	treatment	NNS
cord-006439-q7m4srvp	24	9	for	for	IN
cord-006439-q7m4srvp	24	10	hypertension	hypertension	NN
cord-006439-q7m4srvp	24	11	and	and	CC
cord-006439-q7m4srvp	24	12	other	other	JJ
cord-006439-q7m4srvp	24	13	diseases	disease	NNS
cord-006439-q7m4srvp	24	14	including	include	VBG
cord-006439-q7m4srvp	24	15	heart	heart	NN
cord-006439-q7m4srvp	24	16	failure	failure	NN
cord-006439-q7m4srvp	24	17	,	,	,
cord-006439-q7m4srvp	24	18	chronic	chronic	JJ
cord-006439-q7m4srvp	24	19	kidney	kidney	NN
cord-006439-q7m4srvp	24	20	disease	disease	NN
cord-006439-q7m4srvp	24	21	,	,	,
cord-006439-q7m4srvp	24	22	diabetic	diabetic	JJ
cord-006439-q7m4srvp	24	23	nephropathy	nephropathy	NN
cord-006439-q7m4srvp	24	24	,	,	,
cord-006439-q7m4srvp	24	25	Marfan	Marfan	NNP
cord-006439-q7m4srvp	24	26	's	's	POS
cord-006439-q7m4srvp	24	27	syndrome	syndrome	NN
cord-006439-q7m4srvp	24	28	,	,	,
cord-006439-q7m4srvp	24	29	and	and	CC
cord-006439-q7m4srvp	24	30	some	some	DT
cord-006439-q7m4srvp	24	31	autoimmune	autoimmune	JJ
cord-006439-q7m4srvp	24	32	diseases	disease	NNS
cord-006439-q7m4srvp	24	33	[	[	-LRB-
cord-006439-q7m4srvp	24	34	5	5	CD
cord-006439-q7m4srvp	24	35	]	]	-RRB-
cord-006439-q7m4srvp	24	36	[	[	-LRB-
cord-006439-q7m4srvp	24	37	6	6	CD
cord-006439-q7m4srvp	24	38	]	]	-RRB-
cord-006439-q7m4srvp	24	39	[	[	-LRB-
cord-006439-q7m4srvp	24	40	7	7	CD
cord-006439-q7m4srvp	24	41	]	]	-RRB-
cord-006439-q7m4srvp	24	42	[	[	-LRB-
cord-006439-q7m4srvp	24	43	8	8	CD
cord-006439-q7m4srvp	24	44	]	]	-RRB-
cord-006439-q7m4srvp	24	45	[	[	-LRB-
cord-006439-q7m4srvp	24	46	9	9	CD
cord-006439-q7m4srvp	24	47	]	]	-RRB-
cord-006439-q7m4srvp	24	48	[	[	-LRB-
cord-006439-q7m4srvp	24	49	10	10	CD
cord-006439-q7m4srvp	24	50	]	]	-RRB-
cord-006439-q7m4srvp	24	51	.	.	.
cord-006439-q7m4srvp	25	1	However	however	RB
cord-006439-q7m4srvp	25	2	,	,	,
cord-006439-q7m4srvp	25	3	it	-PRON-	PRP
cord-006439-q7m4srvp	25	4	is	be	VBZ
cord-006439-q7m4srvp	25	5	unclear	unclear	JJ
cord-006439-q7m4srvp	25	6	why	why	WRB
cord-006439-q7m4srvp	25	7	these	these	DT
cord-006439-q7m4srvp	25	8	drugs	drug	NNS
cord-006439-q7m4srvp	25	9	are	be	VBP
cord-006439-q7m4srvp	25	10	effective	effective	JJ
cord-006439-q7m4srvp	25	11	even	even	RB
cord-006439-q7m4srvp	25	12	in	in	IN
cord-006439-q7m4srvp	25	13	patients	patient	NNS
cord-006439-q7m4srvp	25	14	exhibiting	exhibit	VBG
cord-006439-q7m4srvp	25	15	low	low	JJ
cord-006439-q7m4srvp	25	16	or	or	CC
cord-006439-q7m4srvp	25	17	normal	normal	JJ
cord-006439-q7m4srvp	25	18	circulating	circulate	VBG
cord-006439-q7m4srvp	25	19	renin	renin	NN
cord-006439-q7m4srvp	25	20	activity	activity	NN
cord-006439-q7m4srvp	25	21	[	[	-LRB-
cord-006439-q7m4srvp	25	22	11	11	CD
cord-006439-q7m4srvp	25	23	,	,	,
cord-006439-q7m4srvp	25	24	12	12	CD
cord-006439-q7m4srvp	25	25	]	]	-RRB-
cord-006439-q7m4srvp	25	26	.	.	.
cord-006439-q7m4srvp	26	1	The	the	DT
cord-006439-q7m4srvp	26	2	answer	answer	NN
cord-006439-q7m4srvp	26	3	to	to	IN
cord-006439-q7m4srvp	26	4	this	this	DT
cord-006439-q7m4srvp	26	5	observation	observation	NN
cord-006439-q7m4srvp	26	6	may	may	MD
cord-006439-q7m4srvp	26	7	lie	lie	VB
cord-006439-q7m4srvp	26	8	in	in	IN
cord-006439-q7m4srvp	26	9	the	the	DT
cord-006439-q7m4srvp	26	10	existence	existence	NN
cord-006439-q7m4srvp	26	11	of	of	IN
cord-006439-q7m4srvp	26	12	an	an	DT
cord-006439-q7m4srvp	26	13	independent	independent	JJ
cord-006439-q7m4srvp	26	14	autocrine	autocrine	NN
cord-006439-q7m4srvp	26	15	/	/	SYM
cord-006439-q7m4srvp	26	16	paracrine	paracrine	JJ
cord-006439-q7m4srvp	26	17	RAS	RAS	NNP
cord-006439-q7m4srvp	26	18	acting	act	VBG
cord-006439-q7m4srvp	26	19	locally	locally	RB
cord-006439-q7m4srvp	26	20	within	within	IN
cord-006439-q7m4srvp	26	21	several	several	JJ
cord-006439-q7m4srvp	26	22	tissues	tissue	NNS
cord-006439-q7m4srvp	26	23	,	,	,
cord-006439-q7m4srvp	26	24	including	include	VBG
cord-006439-q7m4srvp	26	25	the	the	DT
cord-006439-q7m4srvp	26	26	brain	brain	NN
cord-006439-q7m4srvp	26	27	.	.	.
cord-006439-q7m4srvp	27	1	The	the	DT
cord-006439-q7m4srvp	27	2	existence	existence	NN
cord-006439-q7m4srvp	27	3	of	of	IN
cord-006439-q7m4srvp	27	4	the	the	DT
cord-006439-q7m4srvp	27	5	brain	brain	NN
cord-006439-q7m4srvp	27	6	RAS	RAS	NNP
cord-006439-q7m4srvp	27	7	,	,	,
cord-006439-q7m4srvp	27	8	which	which	WDT
cord-006439-q7m4srvp	27	9	was	be	VBD
cord-006439-q7m4srvp	27	10	initially	initially	RB
cord-006439-q7m4srvp	27	11	proposed	propose	VBN
cord-006439-q7m4srvp	27	12	by	by	IN
cord-006439-q7m4srvp	27	13	Bickerton	Bickerton	NNP
cord-006439-q7m4srvp	27	14	and	and	CC
cord-006439-q7m4srvp	27	15	Buckley	Buckley	NNP
cord-006439-q7m4srvp	27	16	in	in	IN
cord-006439-q7m4srvp	27	17	1961	1961	CD
cord-006439-q7m4srvp	27	18	,	,	,
cord-006439-q7m4srvp	27	19	has	have	VBZ
cord-006439-q7m4srvp	27	20	changed	change	VBN
cord-006439-q7m4srvp	27	21	the	the	DT
cord-006439-q7m4srvp	27	22	traditional	traditional	JJ
cord-006439-q7m4srvp	27	23	view	view	NN
cord-006439-q7m4srvp	27	24	of	of	IN
cord-006439-q7m4srvp	27	25	the	the	DT
cord-006439-q7m4srvp	27	26	RAS	RAS	NNP
cord-006439-q7m4srvp	27	27	[	[	-LRB-
cord-006439-q7m4srvp	27	28	13	13	CD
cord-006439-q7m4srvp	27	29	]	]	-RRB-
cord-006439-q7m4srvp	27	30	.	.	.
cord-006439-q7m4srvp	28	1	Since	since	IN
cord-006439-q7m4srvp	28	2	the	the	DT
cord-006439-q7m4srvp	28	3	discovery	discovery	NN
cord-006439-q7m4srvp	28	4	that	that	IN
cord-006439-q7m4srvp	28	5	central	central	JJ
cord-006439-q7m4srvp	28	6	ANG	ANG	NNP
cord-006439-q7m4srvp	28	7	-	-	HYPH
cord-006439-q7m4srvp	28	8	II	II	NNP
cord-006439-q7m4srvp	28	9	induces	induce	VBZ
cord-006439-q7m4srvp	28	10	a	a	DT
cord-006439-q7m4srvp	28	11	potent	potent	JJ
cord-006439-q7m4srvp	28	12	pressor	pressor	NN
cord-006439-q7m4srvp	28	13	response	response	NN
cord-006439-q7m4srvp	28	14	,	,	,
cord-006439-q7m4srvp	28	15	several	several	JJ
cord-006439-q7m4srvp	28	16	new	new	JJ
cord-006439-q7m4srvp	28	17	functions	function	NNS
cord-006439-q7m4srvp	28	18	of	of	IN
cord-006439-q7m4srvp	28	19	the	the	DT
cord-006439-q7m4srvp	28	20	brain	brain	NN
cord-006439-q7m4srvp	28	21	RAS	RAS	NNP
cord-006439-q7m4srvp	28	22	have	have	VBP
cord-006439-q7m4srvp	28	23	been	be	VBN
cord-006439-q7m4srvp	28	24	identified	identify	VBN
cord-006439-q7m4srvp	28	25	.	.	.
cord-006439-q7m4srvp	29	1	Central	central	JJ
cord-006439-q7m4srvp	29	2	administration	administration	NN
cord-006439-q7m4srvp	29	3	of	of	IN
cord-006439-q7m4srvp	29	4	ANG	ANG	NNP
cord-006439-q7m4srvp	29	5	-	-	HYPH
cord-006439-q7m4srvp	29	6	II	II	NNP
cord-006439-q7m4srvp	29	7	elicits	elicit	VBZ
cord-006439-q7m4srvp	29	8	potent	potent	JJ
cord-006439-q7m4srvp	29	9	dipsogenic	dipsogenic	JJ
cord-006439-q7m4srvp	29	10	responses	response	NNS
cord-006439-q7m4srvp	29	11	,	,	,
cord-006439-q7m4srvp	29	12	induces	induce	VBZ
cord-006439-q7m4srvp	29	13	sodium	sodium	NN
cord-006439-q7m4srvp	29	14	intake	intake	NN
cord-006439-q7m4srvp	29	15	,	,	,
cord-006439-q7m4srvp	29	16	triggers	trigger	VBZ
cord-006439-q7m4srvp	29	17	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	29	18	outflow	outflow	NN
cord-006439-q7m4srvp	29	19	to	to	IN
cord-006439-q7m4srvp	29	20	the	the	DT
cord-006439-q7m4srvp	29	21	kidney	kidney	NN
cord-006439-q7m4srvp	29	22	and	and	CC
cord-006439-q7m4srvp	29	23	other	other	JJ
cord-006439-q7m4srvp	29	24	organs	organ	NNS
cord-006439-q7m4srvp	29	25	,	,	,
cord-006439-q7m4srvp	29	26	and	and	CC
cord-006439-q7m4srvp	29	27	recently	recently	RB
cord-006439-q7m4srvp	29	28	,	,	,
cord-006439-q7m4srvp	29	29	evidence	evidence	NN
cord-006439-q7m4srvp	29	30	has	have	VBZ
cord-006439-q7m4srvp	29	31	established	establish	VBN
cord-006439-q7m4srvp	29	32	that	that	IN
cord-006439-q7m4srvp	29	33	the	the	DT
cord-006439-q7m4srvp	29	34	brain	brain	NN
cord-006439-q7m4srvp	29	35	RAS	RAS	NNP
cord-006439-q7m4srvp	29	36	modulates	modulate	VBZ
cord-006439-q7m4srvp	29	37	metabolic	metabolic	JJ
cord-006439-q7m4srvp	29	38	function	function	NN
cord-006439-q7m4srvp	29	39	primarily	primarily	RB
cord-006439-q7m4srvp	29	40	through	through	IN
cord-006439-q7m4srvp	29	41	distinct	distinct	JJ
cord-006439-q7m4srvp	29	42	nuclei	nucleus	NNS
cord-006439-q7m4srvp	29	43	within	within	IN
cord-006439-q7m4srvp	29	44	the	the	DT
cord-006439-q7m4srvp	29	45	hypothalamus	hypothalamus	NN
cord-006439-q7m4srvp	29	46	[	[	-LRB-
cord-006439-q7m4srvp	29	47	14	14	CD
cord-006439-q7m4srvp	29	48	]	]	-RRB-
cord-006439-q7m4srvp	29	49	[	[	-LRB-
cord-006439-q7m4srvp	29	50	15	15	CD
cord-006439-q7m4srvp	29	51	]	]	-RRB-
cord-006439-q7m4srvp	29	52	[	[	-LRB-
cord-006439-q7m4srvp	29	53	16	16	CD
cord-006439-q7m4srvp	29	54	]	]	-RRB-
cord-006439-q7m4srvp	29	55	[	[	-LRB-
cord-006439-q7m4srvp	29	56	17	17	CD
cord-006439-q7m4srvp	29	57	]	]	-RRB-
cord-006439-q7m4srvp	29	58	.	.	.
cord-006439-q7m4srvp	30	1	Most	Most	JJS
cord-006439-q7m4srvp	30	2	of	of	IN
cord-006439-q7m4srvp	30	3	these	these	DT
cord-006439-q7m4srvp	30	4	effects	effect	NNS
cord-006439-q7m4srvp	30	5	can	can	MD
cord-006439-q7m4srvp	30	6	be	be	VB
cord-006439-q7m4srvp	30	7	attenuated	attenuate	VBN
cord-006439-q7m4srvp	30	8	by	by	IN
cord-006439-q7m4srvp	30	9	administration	administration	NN
cord-006439-q7m4srvp	30	10	of	of	IN
cord-006439-q7m4srvp	30	11	RAS	RAS	NNP
cord-006439-q7m4srvp	30	12	blockers	blocker	NNS
cord-006439-q7m4srvp	30	13	or	or	CC
cord-006439-q7m4srvp	30	14	by	by	IN
cord-006439-q7m4srvp	30	15	genetically	genetically	RB
cord-006439-q7m4srvp	30	16	ablating	ablate	VBG
cord-006439-q7m4srvp	30	17	AT	at	IN
cord-006439-q7m4srvp	30	18	1	1	CD
cord-006439-q7m4srvp	30	19	R	r	NN
cord-006439-q7m4srvp	30	20	in	in	IN
cord-006439-q7m4srvp	30	21	specific	specific	JJ
cord-006439-q7m4srvp	30	22	brain	brain	NN
cord-006439-q7m4srvp	30	23	regions	region	NNS
cord-006439-q7m4srvp	30	24	or	or	CC
cord-006439-q7m4srvp	30	25	cell	cell	NN
cord-006439-q7m4srvp	30	26	types	type	NNS
cord-006439-q7m4srvp	30	27	[	[	-LRB-
cord-006439-q7m4srvp	30	28	18	18	CD
cord-006439-q7m4srvp	30	29	]	]	-RRB-
cord-006439-q7m4srvp	30	30	[	[	-LRB-
cord-006439-q7m4srvp	30	31	19	19	CD
cord-006439-q7m4srvp	30	32	]	]	-RRB-
cord-006439-q7m4srvp	30	33	[	[	-LRB-
cord-006439-q7m4srvp	30	34	20	20	CD
cord-006439-q7m4srvp	30	35	]	]	-RRB-
cord-006439-q7m4srvp	30	36	.	.	.
cord-006439-q7m4srvp	31	1	Resistant	resistant	JJ
cord-006439-q7m4srvp	31	2	hypertension	hypertension	NN
cord-006439-q7m4srvp	31	3	,	,	,
cord-006439-q7m4srvp	31	4	in	in	IN
cord-006439-q7m4srvp	31	5	which	which	WDT
cord-006439-q7m4srvp	31	6	high	high	JJ
cord-006439-q7m4srvp	31	7	blood	blood	NN
cord-006439-q7m4srvp	31	8	pressure	pressure	NN
cord-006439-q7m4srvp	31	9	remains	remain	VBZ
cord-006439-q7m4srvp	31	10	above	above	IN
cord-006439-q7m4srvp	31	11	140/90	140/90	NN
cord-006439-q7m4srvp	31	12	mmHg	mmHg	NNS
cord-006439-q7m4srvp	31	13	despite	despite	IN
cord-006439-q7m4srvp	31	14	use	use	NN
cord-006439-q7m4srvp	31	15	of	of	IN
cord-006439-q7m4srvp	31	16	3	3	CD
cord-006439-q7m4srvp	31	17	or	or	CC
cord-006439-q7m4srvp	31	18	more	more	JJR
cord-006439-q7m4srvp	31	19	antihypertensive	antihypertensive	JJ
cord-006439-q7m4srvp	31	20	drugs	drug	NNS
cord-006439-q7m4srvp	31	21	(	(	-LRB-
cord-006439-q7m4srvp	31	22	including	include	VBG
cord-006439-q7m4srvp	31	23	a	a	DT
cord-006439-q7m4srvp	31	24	diuretic	diuretic	NN
cord-006439-q7m4srvp	31	25	)	)	-RRB-
cord-006439-q7m4srvp	31	26	,	,	,
cord-006439-q7m4srvp	31	27	accounts	account	VBZ
cord-006439-q7m4srvp	31	28	for	for	IN
cord-006439-q7m4srvp	31	29	approximately	approximately	RB
cord-006439-q7m4srvp	31	30	10	10	CD
cord-006439-q7m4srvp	31	31	%	%	NN
cord-006439-q7m4srvp	31	32	of	of	IN
cord-006439-q7m4srvp	31	33	patients	patient	NNS
cord-006439-q7m4srvp	31	34	with	with	IN
cord-006439-q7m4srvp	31	35	essential	essential	JJ
cord-006439-q7m4srvp	31	36	hypertension	hypertension	NN
cord-006439-q7m4srvp	31	37	[	[	-LRB-
cord-006439-q7m4srvp	31	38	21	21	CD
cord-006439-q7m4srvp	31	39	]	]	-RRB-
cord-006439-q7m4srvp	31	40	.	.	.
cord-006439-q7m4srvp	32	1	Resistant	resistant	JJ
cord-006439-q7m4srvp	32	2	hypertension	hypertension	NN
cord-006439-q7m4srvp	32	3	and	and	CC
cord-006439-q7m4srvp	32	4	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	32	5	overactivity	overactivity	NN
cord-006439-q7m4srvp	32	6	have	have	VBP
cord-006439-q7m4srvp	32	7	been	be	VBN
cord-006439-q7m4srvp	32	8	linked	link	VBN
cord-006439-q7m4srvp	32	9	to	to	IN
cord-006439-q7m4srvp	32	10	brain	brain	NN
cord-006439-q7m4srvp	32	11	RAS	RAS	NNP
cord-006439-q7m4srvp	32	12	overactivation	overactivation	NN
cord-006439-q7m4srvp	32	13	[	[	-LRB-
cord-006439-q7m4srvp	32	14	22	22	CD
cord-006439-q7m4srvp	32	15	]	]	-RRB-
cord-006439-q7m4srvp	32	16	.	.	.
cord-006439-q7m4srvp	33	1	Thus	thus	RB
cord-006439-q7m4srvp	33	2	,	,	,
cord-006439-q7m4srvp	33	3	novel	novel	JJ
cord-006439-q7m4srvp	33	4	drugs	drug	NNS
cord-006439-q7m4srvp	33	5	targeting	target	VBG
cord-006439-q7m4srvp	33	6	the	the	DT
cord-006439-q7m4srvp	33	7	brain	brain	NN
cord-006439-q7m4srvp	33	8	RAS	RAS	NNP
cord-006439-q7m4srvp	33	9	might	may	MD
cord-006439-q7m4srvp	33	10	be	be	VB
cord-006439-q7m4srvp	33	11	useful	useful	JJ
cord-006439-q7m4srvp	33	12	to	to	TO
cord-006439-q7m4srvp	33	13	treat	treat	VB
cord-006439-q7m4srvp	33	14	resistant	resistant	JJ
cord-006439-q7m4srvp	33	15	hypertension	hypertension	NN
cord-006439-q7m4srvp	33	16	and/or	and/or	CC
cord-006439-q7m4srvp	33	17	diseases	disease	NNS
cord-006439-q7m4srvp	33	18	associated	associate	VBN
cord-006439-q7m4srvp	33	19	with	with	IN
cord-006439-q7m4srvp	33	20	elevated	elevated	JJ
cord-006439-q7m4srvp	33	21	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	33	22	outflow	outflow	NN
cord-006439-q7m4srvp	33	23	such	such	JJ
cord-006439-q7m4srvp	33	24	as	as	IN
cord-006439-q7m4srvp	33	25	heart	heart	NN
cord-006439-q7m4srvp	33	26	failure	failure	NN
cord-006439-q7m4srvp	33	27	[	[	-LRB-
cord-006439-q7m4srvp	33	28	23	23	CD
cord-006439-q7m4srvp	33	29	]	]	-RRB-
cord-006439-q7m4srvp	33	30	.	.	.
cord-006439-q7m4srvp	34	1	This	this	DT
cord-006439-q7m4srvp	34	2	article	article	NN
cord-006439-q7m4srvp	34	3	aims	aim	VBZ
cord-006439-q7m4srvp	34	4	to	to	TO
cord-006439-q7m4srvp	34	5	bring	bring	VB
cord-006439-q7m4srvp	34	6	the	the	DT
cord-006439-q7m4srvp	34	7	reader	reader	NN
cord-006439-q7m4srvp	34	8	up	up	RP
cord-006439-q7m4srvp	34	9	-	-	HYPH
cord-006439-q7m4srvp	34	10	to	to	IN
cord-006439-q7m4srvp	34	11	-	-	HYPH
cord-006439-q7m4srvp	34	12	date	date	NN
cord-006439-q7m4srvp	34	13	on	on	IN
cord-006439-q7m4srvp	34	14	the	the	DT
cord-006439-q7m4srvp	34	15	important	important	JJ
cord-006439-q7m4srvp	34	16	new	new	JJ
cord-006439-q7m4srvp	34	17	findings	finding	NNS
cord-006439-q7m4srvp	34	18	and	and	CC
cord-006439-q7m4srvp	34	19	the	the	DT
cord-006439-q7m4srvp	34	20	currently	currently	RB
cord-006439-q7m4srvp	34	21	controversial	controversial	JJ
cord-006439-q7m4srvp	34	22	topics	topic	NNS
cord-006439-q7m4srvp	34	23	in	in	IN
cord-006439-q7m4srvp	34	24	the	the	DT
cord-006439-q7m4srvp	34	25	field	field	NN
cord-006439-q7m4srvp	34	26	.	.	.
cord-006439-q7m4srvp	35	1	Then	then	RB
cord-006439-q7m4srvp	35	2	,	,	,
cord-006439-q7m4srvp	35	3	novel	novel	JJ
cord-006439-q7m4srvp	35	4	translatable	translatable	JJ
cord-006439-q7m4srvp	35	5	strategies	strategy	NNS
cord-006439-q7m4srvp	35	6	to	to	TO
cord-006439-q7m4srvp	35	7	attenuate	attenuate	VB
cord-006439-q7m4srvp	35	8	the	the	DT
cord-006439-q7m4srvp	35	9	upregulation	upregulation	NN
cord-006439-q7m4srvp	35	10	of	of	IN
cord-006439-q7m4srvp	35	11	brain	brain	NN
cord-006439-q7m4srvp	35	12	RAS	RAS	NNP
cord-006439-q7m4srvp	35	13	activity	activity	NN
cord-006439-q7m4srvp	35	14	in	in	IN
cord-006439-q7m4srvp	35	15	human	human	JJ
cord-006439-q7m4srvp	35	16	resistant	resistant	JJ
cord-006439-q7m4srvp	35	17	hypertension	hypertension	NN
cord-006439-q7m4srvp	35	18	will	will	MD
cord-006439-q7m4srvp	35	19	be	be	VB
cord-006439-q7m4srvp	35	20	also	also	RB
cord-006439-q7m4srvp	35	21	discussed	discuss	VBN
cord-006439-q7m4srvp	35	22	.	.	.
cord-006439-q7m4srvp	36	1	Although	although	IN
cord-006439-q7m4srvp	36	2	more	more	JJR
cord-006439-q7m4srvp	36	3	than	than	IN
cord-006439-q7m4srvp	36	4	50	50	CD
cord-006439-q7m4srvp	36	5	years	year	NNS
cord-006439-q7m4srvp	36	6	of	of	IN
cord-006439-q7m4srvp	36	7	research	research	NN
cord-006439-q7m4srvp	36	8	supports	support	VBZ
cord-006439-q7m4srvp	36	9	the	the	DT
cord-006439-q7m4srvp	36	10	important	important	JJ
cord-006439-q7m4srvp	36	11	role	role	NN
cord-006439-q7m4srvp	36	12	of	of	IN
cord-006439-q7m4srvp	36	13	the	the	DT
cord-006439-q7m4srvp	36	14	brain	brain	NN
cord-006439-q7m4srvp	36	15	RAS	RAS	NNP
cord-006439-q7m4srvp	36	16	in	in	IN
cord-006439-q7m4srvp	36	17	modulating	modulate	VBG
cord-006439-q7m4srvp	36	18	several	several	JJ
cord-006439-q7m4srvp	36	19	physiological	physiological	JJ
cord-006439-q7m4srvp	36	20	functions	function	NNS
cord-006439-q7m4srvp	36	21	,	,	,
cord-006439-q7m4srvp	36	22	it	-PRON-	PRP
cord-006439-q7m4srvp	36	23	is	be	VBZ
cord-006439-q7m4srvp	36	24	not	not	RB
cord-006439-q7m4srvp	36	25	completely	completely	RB
cord-006439-q7m4srvp	36	26	clear	clear	JJ
cord-006439-q7m4srvp	36	27	how	how	WRB
cord-006439-q7m4srvp	36	28	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	36	29	peptides	peptide	NNS
cord-006439-q7m4srvp	36	30	are	be	VBP
cord-006439-q7m4srvp	36	31	generated	generate	VBN
cord-006439-q7m4srvp	36	32	within	within	IN
cord-006439-q7m4srvp	36	33	the	the	DT
cord-006439-q7m4srvp	36	34	central	central	JJ
cord-006439-q7m4srvp	36	35	nervous	nervous	JJ
cord-006439-q7m4srvp	36	36	system	system	NN
cord-006439-q7m4srvp	36	37	(	(	-LRB-
cord-006439-q7m4srvp	36	38	CNS	CNS	NNP
cord-006439-q7m4srvp	36	39	)	)	-RRB-
cord-006439-q7m4srvp	36	40	.	.	.
cord-006439-q7m4srvp	37	1	There	there	EX
cord-006439-q7m4srvp	37	2	is	be	VBZ
cord-006439-q7m4srvp	37	3	extensive	extensive	JJ
cord-006439-q7m4srvp	37	4	evidence	evidence	NN
cord-006439-q7m4srvp	37	5	indicating	indicate	VBG
cord-006439-q7m4srvp	37	6	that	that	IN
cord-006439-q7m4srvp	37	7	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	37	8	is	be	VBZ
cord-006439-q7m4srvp	37	9	highly	highly	RB
cord-006439-q7m4srvp	37	10	expressed	express	VBN
cord-006439-q7m4srvp	37	11	in	in	IN
cord-006439-q7m4srvp	37	12	astrocytes	astrocyte	NNS
cord-006439-q7m4srvp	37	13	and	and	CC
cord-006439-q7m4srvp	37	14	in	in	IN
cord-006439-q7m4srvp	37	15	some	some	DT
cord-006439-q7m4srvp	37	16	specific	specific	JJ
cord-006439-q7m4srvp	37	17	populations	population	NNS
cord-006439-q7m4srvp	37	18	of	of	IN
cord-006439-q7m4srvp	37	19	neurons	neuron	NNS
cord-006439-q7m4srvp	37	20	,	,	,
cord-006439-q7m4srvp	37	21	which	which	WDT
cord-006439-q7m4srvp	37	22	suggests	suggest	VBZ
cord-006439-q7m4srvp	37	23	that	that	IN
cord-006439-q7m4srvp	37	24	the	the	DT
cord-006439-q7m4srvp	37	25	extracellular	extracellular	JJ
cord-006439-q7m4srvp	37	26	space	space	NN
cord-006439-q7m4srvp	37	27	of	of	IN
cord-006439-q7m4srvp	37	28	the	the	DT
cord-006439-q7m4srvp	37	29	CNS	CNS	NNP
cord-006439-q7m4srvp	37	30	has	have	VBZ
cord-006439-q7m4srvp	37	31	abundant	abundant	JJ
cord-006439-q7m4srvp	37	32	renin	renin	NN
cord-006439-q7m4srvp	37	33	substrate	substrate	NN
cord-006439-q7m4srvp	37	34	[	[	-LRB-
cord-006439-q7m4srvp	37	35	19	19	CD
cord-006439-q7m4srvp	37	36	,	,	,
cord-006439-q7m4srvp	37	37	[	[	-LRB-
cord-006439-q7m4srvp	37	38	24	24	CD
cord-006439-q7m4srvp	37	39	]	]	-RRB-
cord-006439-q7m4srvp	37	40	[	[	-LRB-
cord-006439-q7m4srvp	37	41	25	25	CD
cord-006439-q7m4srvp	37	42	]	]	-RRB-
cord-006439-q7m4srvp	37	43	[	[	-LRB-
cord-006439-q7m4srvp	37	44	26	26	CD
cord-006439-q7m4srvp	37	45	]	]	-RRB-
cord-006439-q7m4srvp	37	46	[	[	-LRB-
cord-006439-q7m4srvp	37	47	27	27	CD
cord-006439-q7m4srvp	37	48	]	]	-RRB-
cord-006439-q7m4srvp	37	49	[	[	-LRB-
cord-006439-q7m4srvp	37	50	28	28	CD
cord-006439-q7m4srvp	37	51	]	]	-RRB-
cord-006439-q7m4srvp	37	52	.	.	.
cord-006439-q7m4srvp	38	1	The	the	DT
cord-006439-q7m4srvp	38	2	distribution	distribution	NN
cord-006439-q7m4srvp	38	3	of	of	IN
cord-006439-q7m4srvp	38	4	the	the	DT
cord-006439-q7m4srvp	38	5	two	two	CD
cord-006439-q7m4srvp	38	6	main	main	JJ
cord-006439-q7m4srvp	38	7	ANG	ANG	NNP
cord-006439-q7m4srvp	38	8	-	-	HYPH
cord-006439-q7m4srvp	38	9	II	II	NNP
cord-006439-q7m4srvp	38	10	receptors	receptor	NNS
cord-006439-q7m4srvp	38	11	,	,	,
cord-006439-q7m4srvp	38	12	AT	at	IN
cord-006439-q7m4srvp	38	13	1	1	CD
cord-006439-q7m4srvp	38	14	R	r	NN
cord-006439-q7m4srvp	38	15	and	and	CC
cord-006439-q7m4srvp	38	16	AT	at	NN
cord-006439-q7m4srvp	38	17	2	2	CD
cord-006439-q7m4srvp	38	18	R	r	NN
cord-006439-q7m4srvp	38	19	,	,	,
cord-006439-q7m4srvp	38	20	was	be	VBD
cord-006439-q7m4srvp	38	21	mapped	map	VBN
cord-006439-q7m4srvp	38	22	initially	initially	RB
cord-006439-q7m4srvp	38	23	by	by	IN
cord-006439-q7m4srvp	38	24	autoradiography	autoradiography	NNP
cord-006439-q7m4srvp	38	25	and	and	CC
cord-006439-q7m4srvp	38	26	subsequently	subsequently	RB
cord-006439-q7m4srvp	38	27	confirmed	confirm	VBN
cord-006439-q7m4srvp	38	28	by	by	IN
cord-006439-q7m4srvp	38	29	either	either	CC
cord-006439-q7m4srvp	38	30	in	in	IN
cord-006439-q7m4srvp	38	31	situ	situ	NN
cord-006439-q7m4srvp	38	32	hybridization	hybridization	NN
cord-006439-q7m4srvp	38	33	or	or	CC
cord-006439-q7m4srvp	38	34	utilizing	utilize	VBG
cord-006439-q7m4srvp	38	35	transgenic	transgenic	JJ
cord-006439-q7m4srvp	38	36	mice	mouse	NNS
cord-006439-q7m4srvp	38	37	expressing	express	VBG
cord-006439-q7m4srvp	38	38	reporter	reporter	NN
cord-006439-q7m4srvp	38	39	genes	gene	NNS
cord-006439-q7m4srvp	38	40	under	under	IN
cord-006439-q7m4srvp	38	41	the	the	DT
cord-006439-q7m4srvp	38	42	control	control	NN
cord-006439-q7m4srvp	38	43	of	of	IN
cord-006439-q7m4srvp	38	44	either	either	DT
cord-006439-q7m4srvp	38	45	AT	AT	NNP
cord-006439-q7m4srvp	38	46	1	1	CD
cord-006439-q7m4srvp	38	47	R	r	NN
cord-006439-q7m4srvp	38	48	or	or	CC
cord-006439-q7m4srvp	38	49	AT	at	NN
cord-006439-q7m4srvp	38	50	2	2	CD
cord-006439-q7m4srvp	38	51	R	r	NN
cord-006439-q7m4srvp	38	52	promoters	promoter	NNS
cord-006439-q7m4srvp	38	53	[	[	-LRB-
cord-006439-q7m4srvp	38	54	29	29	CD
cord-006439-q7m4srvp	38	55	,	,	,
cord-006439-q7m4srvp	38	56	30	30	CD
cord-006439-q7m4srvp	38	57	,	,	,
cord-006439-q7m4srvp	38	58	31•	31•	CD
cord-006439-q7m4srvp	38	59	]	]	-RRB-
cord-006439-q7m4srvp	38	60	.	.	.
cord-006439-q7m4srvp	39	1	AT	at	IN
cord-006439-q7m4srvp	39	2	1	1	CD
cord-006439-q7m4srvp	39	3	R	r	NN
cord-006439-q7m4srvp	39	4	is	be	VBZ
cord-006439-q7m4srvp	39	5	highly	highly	RB
cord-006439-q7m4srvp	39	6	expressed	express	VBN
cord-006439-q7m4srvp	39	7	in	in	IN
cord-006439-q7m4srvp	39	8	most	most	JJS
cord-006439-q7m4srvp	39	9	of	of	IN
cord-006439-q7m4srvp	39	10	the	the	DT
cord-006439-q7m4srvp	39	11	circumventricular	circumventricular	JJ
cord-006439-q7m4srvp	39	12	organs	organ	NNS
cord-006439-q7m4srvp	39	13	such	such	JJ
cord-006439-q7m4srvp	39	14	as	as	IN
cord-006439-q7m4srvp	39	15	the	the	DT
cord-006439-q7m4srvp	39	16	subfornical	subfornical	JJ
cord-006439-q7m4srvp	39	17	organ	organ	NN
cord-006439-q7m4srvp	39	18	,	,	,
cord-006439-q7m4srvp	39	19	the	the	DT
cord-006439-q7m4srvp	39	20	organum	organum	NNP
cord-006439-q7m4srvp	39	21	vasculosum	vasculosum	NNP
cord-006439-q7m4srvp	39	22	laminae	laminae	NNP
cord-006439-q7m4srvp	39	23	terminalis	terminalis	NNP
cord-006439-q7m4srvp	39	24	(	(	-LRB-
cord-006439-q7m4srvp	39	25	OVLT	OVLT	NNP
cord-006439-q7m4srvp	39	26	)	)	-RRB-
cord-006439-q7m4srvp	39	27	,	,	,
cord-006439-q7m4srvp	39	28	and	and	CC
cord-006439-q7m4srvp	39	29	the	the	DT
cord-006439-q7m4srvp	39	30	area	area	NN
cord-006439-q7m4srvp	39	31	postrema	postrema	NNP
cord-006439-q7m4srvp	39	32	.	.	.
cord-006439-q7m4srvp	40	1	However	however	RB
cord-006439-q7m4srvp	40	2	,	,	,
cord-006439-q7m4srvp	40	3	the	the	DT
cord-006439-q7m4srvp	40	4	elevated	elevated	JJ
cord-006439-q7m4srvp	40	5	expression	expression	NN
cord-006439-q7m4srvp	40	6	of	of	IN
cord-006439-q7m4srvp	40	7	AT	AT	NNP
cord-006439-q7m4srvp	40	8	1	1	CD
cord-006439-q7m4srvp	40	9	R	r	NN
cord-006439-q7m4srvp	40	10	in	in	IN
cord-006439-q7m4srvp	40	11	some	some	DT
cord-006439-q7m4srvp	40	12	regions	region	NNS
cord-006439-q7m4srvp	40	13	behind	behind	IN
cord-006439-q7m4srvp	40	14	the	the	DT
cord-006439-q7m4srvp	40	15	bloodbrain	bloodbrain	NN
cord-006439-q7m4srvp	40	16	barrier	barrier	NN
cord-006439-q7m4srvp	40	17	such	such	JJ
cord-006439-q7m4srvp	40	18	as	as	IN
cord-006439-q7m4srvp	40	19	the	the	DT
cord-006439-q7m4srvp	40	20	paraventricular	paraventricular	NNP
cord-006439-q7m4srvp	40	21	nucleus	nucleus	NN
cord-006439-q7m4srvp	40	22	of	of	IN
cord-006439-q7m4srvp	40	23	the	the	DT
cord-006439-q7m4srvp	40	24	hypothalamus	hypothalamus	NN
cord-006439-q7m4srvp	40	25	(	(	-LRB-
cord-006439-q7m4srvp	40	26	PVN	PVN	NNP
cord-006439-q7m4srvp	40	27	)	)	-RRB-
cord-006439-q7m4srvp	40	28	,	,	,
cord-006439-q7m4srvp	40	29	the	the	DT
cord-006439-q7m4srvp	40	30	nucleus	nucleus	NN
cord-006439-q7m4srvp	40	31	tractus	tractus	NN
cord-006439-q7m4srvp	40	32	solitarius	solitarius	NN
cord-006439-q7m4srvp	40	33	(	(	-LRB-
cord-006439-q7m4srvp	40	34	NTS	NTS	NNP
cord-006439-q7m4srvp	40	35	)	)	-RRB-
cord-006439-q7m4srvp	40	36	,	,	,
cord-006439-q7m4srvp	40	37	the	the	DT
cord-006439-q7m4srvp	40	38	rostral	rostral	JJ
cord-006439-q7m4srvp	40	39	and	and	CC
cord-006439-q7m4srvp	40	40	caudal	caudal	JJ
cord-006439-q7m4srvp	40	41	ventrolateral	ventrolateral	JJ
cord-006439-q7m4srvp	40	42	medulla	medulla	NN
cord-006439-q7m4srvp	40	43	(	(	-LRB-
cord-006439-q7m4srvp	40	44	RVLM	RVLM	NNP
cord-006439-q7m4srvp	40	45	and	and	CC
cord-006439-q7m4srvp	40	46	CVLM	CVLM	NNP
cord-006439-q7m4srvp	40	47	,	,	,
cord-006439-q7m4srvp	40	48	respectively	respectively	RB
cord-006439-q7m4srvp	40	49	)	)	-RRB-
cord-006439-q7m4srvp	40	50	,	,	,
cord-006439-q7m4srvp	40	51	the	the	DT
cord-006439-q7m4srvp	40	52	medial	medial	JJ
cord-006439-q7m4srvp	40	53	preoptic	preoptic	JJ
cord-006439-q7m4srvp	40	54	nucleus	nucleus	NN
cord-006439-q7m4srvp	40	55	(	(	-LRB-
cord-006439-q7m4srvp	40	56	MnPO	MnPO	NNP
cord-006439-q7m4srvp	40	57	)	)	-RRB-
cord-006439-q7m4srvp	40	58	,	,	,
cord-006439-q7m4srvp	40	59	and	and	CC
cord-006439-q7m4srvp	40	60	some	some	DT
cord-006439-q7m4srvp	40	61	neurons	neuron	NNS
cord-006439-q7m4srvp	40	62	within	within	IN
cord-006439-q7m4srvp	40	63	the	the	DT
cord-006439-q7m4srvp	40	64	arcuate	arcuate	JJ
cord-006439-q7m4srvp	40	65	nucleus	nucleus	NN
cord-006439-q7m4srvp	40	66	(	(	-LRB-
cord-006439-q7m4srvp	40	67	ARC	ARC	NNP
cord-006439-q7m4srvp	40	68	)	)	-RRB-
cord-006439-q7m4srvp	40	69	suggests	suggest	VBZ
cord-006439-q7m4srvp	40	70	a	a	DT
cord-006439-q7m4srvp	40	71	role	role	NN
cord-006439-q7m4srvp	40	72	for	for	IN
cord-006439-q7m4srvp	40	73	ANG	ANG	NNP
cord-006439-q7m4srvp	40	74	-	-	HYPH
cord-006439-q7m4srvp	40	75	II	II	NNP
cord-006439-q7m4srvp	40	76	as	as	IN
cord-006439-q7m4srvp	40	77	a	a	DT
cord-006439-q7m4srvp	40	78	neuromodulator	neuromodulator	NN
cord-006439-q7m4srvp	40	79	.	.	.
cord-006439-q7m4srvp	41	1	Expression	expression	NN
cord-006439-q7m4srvp	41	2	of	of	IN
cord-006439-q7m4srvp	41	3	AT	AT	NNP
cord-006439-q7m4srvp	41	4	2	2	CD
cord-006439-q7m4srvp	41	5	R	r	NN
cord-006439-q7m4srvp	41	6	in	in	IN
cord-006439-q7m4srvp	41	7	the	the	DT
cord-006439-q7m4srvp	41	8	brain	brain	NN
cord-006439-q7m4srvp	41	9	predominates	predominate	VBZ
cord-006439-q7m4srvp	41	10	over	over	IN
cord-006439-q7m4srvp	41	11	AT	at	IN
cord-006439-q7m4srvp	41	12	1	1	CD
cord-006439-q7m4srvp	41	13	R	r	NN
cord-006439-q7m4srvp	41	14	expression	expression	NN
cord-006439-q7m4srvp	41	15	during	during	IN
cord-006439-q7m4srvp	41	16	fetal	fetal	JJ
cord-006439-q7m4srvp	41	17	development	development	NN
cord-006439-q7m4srvp	41	18	[	[	-LRB-
cord-006439-q7m4srvp	41	19	32	32	CD
cord-006439-q7m4srvp	41	20	]	]	-RRB-
cord-006439-q7m4srvp	41	21	.	.	.
cord-006439-q7m4srvp	42	1	However	however	RB
cord-006439-q7m4srvp	42	2	,	,	,
cord-006439-q7m4srvp	42	3	recent	recent	JJ
cord-006439-q7m4srvp	42	4	studies	study	NNS
cord-006439-q7m4srvp	42	5	from	from	IN
cord-006439-q7m4srvp	42	6	De	De	NNP
cord-006439-q7m4srvp	42	7	Kloet	Kloet	NNP
cord-006439-q7m4srvp	42	8	et	et	FW
cord-006439-q7m4srvp	42	9	al	al	NNP
cord-006439-q7m4srvp	42	10	.	.	.
cord-006439-q7m4srvp	43	1	utilizing	utilize	VBG
cord-006439-q7m4srvp	43	2	bacterial	bacterial	JJ
cord-006439-q7m4srvp	43	3	artificial	artificial	JJ
cord-006439-q7m4srvp	43	4	chromosome	chromosome	NN
cord-006439-q7m4srvp	43	5	transgenic	transgenic	JJ
cord-006439-q7m4srvp	43	6	AT	at	IN
cord-006439-q7m4srvp	43	7	2	2	CD
cord-006439-q7m4srvp	43	8	R	r	NN
cord-006439-q7m4srvp	43	9	-	-	HYPH
cord-006439-q7m4srvp	43	10	enhanced	enhance	VBN
cord-006439-q7m4srvp	43	11	green	green	JJ
cord-006439-q7m4srvp	43	12	fluorescent	fluorescent	NN
cord-006439-q7m4srvp	43	13	protein	protein	NN
cord-006439-q7m4srvp	43	14	(	(	-LRB-
cord-006439-q7m4srvp	43	15	eGFP	egfp	NN
cord-006439-q7m4srvp	43	16	)	)	-RRB-
cord-006439-q7m4srvp	44	1	reporter	reporter	NN
cord-006439-q7m4srvp	44	2	mouse	mouse	NN
cord-006439-q7m4srvp	44	3	confirmed	confirm	VBD
cord-006439-q7m4srvp	44	4	the	the	DT
cord-006439-q7m4srvp	44	5	presence	presence	NN
cord-006439-q7m4srvp	44	6	of	of	IN
cord-006439-q7m4srvp	44	7	AT	AT	NNP
cord-006439-q7m4srvp	44	8	2	2	CD
cord-006439-q7m4srvp	44	9	R	r	NN
cord-006439-q7m4srvp	44	10	in	in	IN
cord-006439-q7m4srvp	44	11	adult	adult	NN
cord-006439-q7m4srvp	44	12	brains	brain	NNS
cord-006439-q7m4srvp	44	13	particularly	particularly	RB
cord-006439-q7m4srvp	44	14	in	in	IN
cord-006439-q7m4srvp	44	15	neurons	neuron	NNS
cord-006439-q7m4srvp	44	16	and/or	and/or	CC
cord-006439-q7m4srvp	44	17	fiber	fiber	NN
cord-006439-q7m4srvp	44	18	terminals	terminal	NNS
cord-006439-q7m4srvp	44	19	in	in	IN
cord-006439-q7m4srvp	44	20	circumventricular	circumventricular	JJ
cord-006439-q7m4srvp	44	21	organs	organ	NNS
cord-006439-q7m4srvp	44	22	,	,	,
cord-006439-q7m4srvp	44	23	hypothalamic	hypothalamic	JJ
cord-006439-q7m4srvp	44	24	nuclei	nucleus	NNS
cord-006439-q7m4srvp	44	25	,	,	,
cord-006439-q7m4srvp	44	26	and	and	CC
cord-006439-q7m4srvp	44	27	the	the	DT
cord-006439-q7m4srvp	44	28	hindbrain	hindbrain	NNP
cord-006439-q7m4srvp	44	29	[	[	-LRB-
cord-006439-q7m4srvp	44	30	30	30	CD
cord-006439-q7m4srvp	44	31	]	]	-RRB-
cord-006439-q7m4srvp	44	32	.	.	.
cord-006439-q7m4srvp	45	1	Although	although	IN
cord-006439-q7m4srvp	45	2	most	most	JJS
cord-006439-q7m4srvp	45	3	of	of	IN
cord-006439-q7m4srvp	45	4	the	the	DT
cord-006439-q7m4srvp	45	5	components	component	NNS
cord-006439-q7m4srvp	45	6	of	of	IN
cord-006439-q7m4srvp	45	7	the	the	DT
cord-006439-q7m4srvp	45	8	RAS	RAS	NNP
cord-006439-q7m4srvp	45	9	have	have	VBP
cord-006439-q7m4srvp	45	10	been	be	VBN
cord-006439-q7m4srvp	45	11	identified	identify	VBN
cord-006439-q7m4srvp	45	12	in	in	IN
cord-006439-q7m4srvp	45	13	the	the	DT
cord-006439-q7m4srvp	45	14	brain	brain	NN
cord-006439-q7m4srvp	45	15	,	,	,
cord-006439-q7m4srvp	45	16	the	the	DT
cord-006439-q7m4srvp	45	17	lack	lack	NN
cord-006439-q7m4srvp	45	18	of	of	IN
cord-006439-q7m4srvp	45	19	a	a	DT
cord-006439-q7m4srvp	45	20	reliable	reliable	JJ
cord-006439-q7m4srvp	45	21	method	method	NN
cord-006439-q7m4srvp	45	22	to	to	TO
cord-006439-q7m4srvp	45	23	detect	detect	VB
cord-006439-q7m4srvp	45	24	renin	renin	NN
cord-006439-q7m4srvp	45	25	in	in	IN
cord-006439-q7m4srvp	45	26	small	small	JJ
cord-006439-q7m4srvp	45	27	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	45	28	structures	structure	NNS
cord-006439-q7m4srvp	45	29	had	have	VBD
cord-006439-q7m4srvp	45	30	led	lead	VBN
cord-006439-q7m4srvp	45	31	some	some	DT
cord-006439-q7m4srvp	45	32	to	to	TO
cord-006439-q7m4srvp	45	33	question	question	VB
cord-006439-q7m4srvp	45	34	whether	whether	IN
cord-006439-q7m4srvp	45	35	the	the	DT
cord-006439-q7m4srvp	45	36	central	central	JJ
cord-006439-q7m4srvp	45	37	generation	generation	NN
cord-006439-q7m4srvp	45	38	of	of	IN
cord-006439-q7m4srvp	45	39	ANG	ANG	NNP
cord-006439-q7m4srvp	45	40	-	-	HYPH
cord-006439-q7m4srvp	45	41	II	II	NNP
cord-006439-q7m4srvp	45	42	requires	require	VBZ
cord-006439-q7m4srvp	45	43	renin	renin	NN
cord-006439-q7m4srvp	45	44	.	.	.
cord-006439-q7m4srvp	46	1	Indeed	indeed	RB
cord-006439-q7m4srvp	46	2	,	,	,
cord-006439-q7m4srvp	46	3	renin	renin	NN
cord-006439-q7m4srvp	46	4	-	-	HYPH
cord-006439-q7m4srvp	46	5	independent	independent	JJ
cord-006439-q7m4srvp	46	6	ANG	ANG	NNP
cord-006439-q7m4srvp	46	7	-	-	HYPH
cord-006439-q7m4srvp	46	8	II	II	NNP
cord-006439-q7m4srvp	46	9	generating	generate	VBG
cord-006439-q7m4srvp	46	10	biochemical	biochemical	JJ
cord-006439-q7m4srvp	46	11	pathways	pathway	NNS
cord-006439-q7m4srvp	46	12	involving	involve	VBG
cord-006439-q7m4srvp	46	13	tonin	tonin	NN
cord-006439-q7m4srvp	46	14	and	and	CC
cord-006439-q7m4srvp	46	15	cathepsin	cathepsin	NN
cord-006439-q7m4srvp	46	16	D	d	NN
cord-006439-q7m4srvp	46	17	have	have	VBP
cord-006439-q7m4srvp	46	18	been	be	VBN
cord-006439-q7m4srvp	46	19	proposed	propose	VBN
cord-006439-q7m4srvp	46	20	[	[	-LRB-
cord-006439-q7m4srvp	46	21	33	33	CD
cord-006439-q7m4srvp	46	22	]	]	-RRB-
cord-006439-q7m4srvp	46	23	[	[	-LRB-
cord-006439-q7m4srvp	46	24	34	34	CD
cord-006439-q7m4srvp	46	25	]	]	-RRB-
cord-006439-q7m4srvp	47	1	[	[	-LRB-
cord-006439-q7m4srvp	47	2	35	35	CD
cord-006439-q7m4srvp	47	3	]	]	-RRB-
cord-006439-q7m4srvp	47	4	[	[	-LRB-
cord-006439-q7m4srvp	47	5	36	36	CD
cord-006439-q7m4srvp	47	6	]	]	-RRB-
cord-006439-q7m4srvp	47	7	.	.	.
cord-006439-q7m4srvp	48	1	Others	other	NNS
cord-006439-q7m4srvp	48	2	have	have	VBP
cord-006439-q7m4srvp	48	3	performed	perform	VBN
cord-006439-q7m4srvp	48	4	experiments	experiment	NNS
cord-006439-q7m4srvp	48	5	which	which	WDT
cord-006439-q7m4srvp	48	6	they	-PRON-	PRP
cord-006439-q7m4srvp	48	7	interpret	interpret	VBP
cord-006439-q7m4srvp	48	8	as	as	IN
cord-006439-q7m4srvp	48	9	a	a	DT
cord-006439-q7m4srvp	48	10	refutation	refutation	NN
cord-006439-q7m4srvp	48	11	of	of	IN
cord-006439-q7m4srvp	48	12	the	the	DT
cord-006439-q7m4srvp	48	13	brain	brain	NN
cord-006439-q7m4srvp	48	14	RAS	RAS	NNP
cord-006439-q7m4srvp	48	15	[	[	-LRB-
cord-006439-q7m4srvp	48	16	37	37	CD
cord-006439-q7m4srvp	48	17	]	]	-RRB-
cord-006439-q7m4srvp	48	18	.	.	.
cord-006439-q7m4srvp	49	1	The	the	DT
cord-006439-q7m4srvp	49	2	difficulties	difficulty	NNS
cord-006439-q7m4srvp	49	3	in	in	IN
cord-006439-q7m4srvp	49	4	measuring	measure	VBG
cord-006439-q7m4srvp	49	5	renin	renin	NN
cord-006439-q7m4srvp	49	6	stem	stem	NN
cord-006439-q7m4srvp	49	7	from	from	IN
cord-006439-q7m4srvp	49	8	several	several	JJ
cord-006439-q7m4srvp	49	9	factors	factor	NNS
cord-006439-q7m4srvp	49	10	.	.	.
cord-006439-q7m4srvp	50	1	First	first	RB
cord-006439-q7m4srvp	50	2	,	,	,
cord-006439-q7m4srvp	50	3	considering	consider	VBG
cord-006439-q7m4srvp	50	4	that	that	IN
cord-006439-q7m4srvp	50	5	renin	renin	NN
cord-006439-q7m4srvp	50	6	is	be	VBZ
cord-006439-q7m4srvp	50	7	the	the	DT
cord-006439-q7m4srvp	50	8	rate	rate	NN
cord-006439-q7m4srvp	50	9	-	-	HYPH
cord-006439-q7m4srvp	50	10	limiting	limit	VBG
cord-006439-q7m4srvp	50	11	enzyme	enzyme	NN
cord-006439-q7m4srvp	50	12	for	for	IN
cord-006439-q7m4srvp	50	13	the	the	DT
cord-006439-q7m4srvp	50	14	generation	generation	NN
cord-006439-q7m4srvp	50	15	of	of	IN
cord-006439-q7m4srvp	50	16	ANG	ANG	NNP
cord-006439-q7m4srvp	50	17	-	-	:
cord-006439-q7m4srvp	50	18	I	I	NNP
cord-006439-q7m4srvp	50	19	,	,	,
cord-006439-q7m4srvp	50	20	and	and	CC
cord-006439-q7m4srvp	50	21	given	give	VBN
cord-006439-q7m4srvp	50	22	the	the	DT
cord-006439-q7m4srvp	50	23	elevated	elevated	JJ
cord-006439-q7m4srvp	50	24	bioavailability	bioavailability	NN
cord-006439-q7m4srvp	50	25	of	of	IN
cord-006439-q7m4srvp	50	26	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	50	27	in	in	IN
cord-006439-q7m4srvp	50	28	the	the	DT
cord-006439-q7m4srvp	50	29	extracellular	extracellular	JJ
cord-006439-q7m4srvp	50	30	space	space	NN
cord-006439-q7m4srvp	50	31	of	of	IN
cord-006439-q7m4srvp	50	32	the	the	DT
cord-006439-q7m4srvp	50	33	brain	brain	NN
cord-006439-q7m4srvp	50	34	,	,	,
cord-006439-q7m4srvp	50	35	it	-PRON-	PRP
cord-006439-q7m4srvp	50	36	is	be	VBZ
cord-006439-q7m4srvp	50	37	expected	expect	VBN
cord-006439-q7m4srvp	50	38	renin	renin	NN
cord-006439-q7m4srvp	50	39	must	must	MD
cord-006439-q7m4srvp	50	40	be	be	VB
cord-006439-q7m4srvp	50	41	tightly	tightly	RB
cord-006439-q7m4srvp	50	42	controlled	control	VBN
cord-006439-q7m4srvp	50	43	and	and	CC
cord-006439-q7m4srvp	50	44	secreted	secrete	VBN
cord-006439-q7m4srvp	50	45	from	from	IN
cord-006439-q7m4srvp	50	46	specific	specific	JJ
cord-006439-q7m4srvp	50	47	cells	cell	NNS
cord-006439-q7m4srvp	50	48	within	within	IN
cord-006439-q7m4srvp	50	49	selected	select	VBN
cord-006439-q7m4srvp	50	50	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	50	51	nuclei	nucleus	NNS
cord-006439-q7m4srvp	50	52	.	.	.
cord-006439-q7m4srvp	51	1	Supporting	support	VBG
cord-006439-q7m4srvp	51	2	this	this	DT
cord-006439-q7m4srvp	51	3	,	,	,
cord-006439-q7m4srvp	51	4	minimal	minimal	JJ
cord-006439-q7m4srvp	51	5	elevation	elevation	NN
cord-006439-q7m4srvp	51	6	of	of	IN
cord-006439-q7m4srvp	51	7	ANG	ANG	NNP
cord-006439-q7m4srvp	51	8	-	-	HYPH
cord-006439-q7m4srvp	51	9	II	II	NNP
cord-006439-q7m4srvp	51	10	levels	level	NNS
cord-006439-q7m4srvp	51	11	in	in	IN
cord-006439-q7m4srvp	51	12	discrete	discrete	JJ
cord-006439-q7m4srvp	51	13	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	51	14	regions	region	NNS
cord-006439-q7m4srvp	51	15	is	be	VBZ
cord-006439-q7m4srvp	51	16	expected	expect	VBN
cord-006439-q7m4srvp	51	17	to	to	TO
cord-006439-q7m4srvp	51	18	elicit	elicit	VB
cord-006439-q7m4srvp	51	19	extremely	extremely	RB
cord-006439-q7m4srvp	51	20	profound	profound	JJ
cord-006439-q7m4srvp	51	21	effects	effect	NNS
cord-006439-q7m4srvp	51	22	.	.	.
cord-006439-q7m4srvp	52	1	Indeed	indeed	RB
cord-006439-q7m4srvp	52	2	,	,	,
cord-006439-q7m4srvp	52	3	evidence	evidence	NN
cord-006439-q7m4srvp	52	4	indicates	indicate	VBZ
cord-006439-q7m4srvp	52	5	that	that	IN
cord-006439-q7m4srvp	52	6	ablation	ablation	NN
cord-006439-q7m4srvp	52	7	or	or	CC
cord-006439-q7m4srvp	52	8	stimulation	stimulation	NN
cord-006439-q7m4srvp	52	9	of	of	IN
cord-006439-q7m4srvp	52	10	angiotensinergic	angiotensinergic	NN
cord-006439-q7m4srvp	52	11	signaling	signal	VBG
cord-006439-q7m4srvp	52	12	within	within	IN
cord-006439-q7m4srvp	52	13	a	a	DT
cord-006439-q7m4srvp	52	14	few	few	JJ
cord-006439-q7m4srvp	52	15	cells	cell	NNS
cord-006439-q7m4srvp	52	16	in	in	IN
cord-006439-q7m4srvp	52	17	the	the	DT
cord-006439-q7m4srvp	52	18	brain	brain	NN
cord-006439-q7m4srvp	52	19	leads	lead	VBZ
cord-006439-q7m4srvp	52	20	to	to	IN
cord-006439-q7m4srvp	52	21	extremely	extremely	RB
cord-006439-q7m4srvp	52	22	prominent	prominent	JJ
cord-006439-q7m4srvp	52	23	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	52	24	and	and	CC
cord-006439-q7m4srvp	52	25	metabolic	metabolic	JJ
cord-006439-q7m4srvp	52	26	phenotypes	phenotype	NNS
cord-006439-q7m4srvp	52	27	[	[	-LRB-
cord-006439-q7m4srvp	52	28	38	38	CD
cord-006439-q7m4srvp	52	29	]	]	-RRB-
cord-006439-q7m4srvp	52	30	[	[	-LRB-
cord-006439-q7m4srvp	52	31	39	39	CD
cord-006439-q7m4srvp	52	32	]	]	-RRB-
cord-006439-q7m4srvp	52	33	[	[	-LRB-
cord-006439-q7m4srvp	52	34	40	40	CD
cord-006439-q7m4srvp	52	35	]	]	-RRB-
cord-006439-q7m4srvp	52	36	.	.	.
cord-006439-q7m4srvp	53	1	Second	second	RB
cord-006439-q7m4srvp	53	2	,	,	,
cord-006439-q7m4srvp	53	3	we	-PRON-	PRP
cord-006439-q7m4srvp	53	4	and	and	CC
cord-006439-q7m4srvp	53	5	others	other	NNS
cord-006439-q7m4srvp	53	6	have	have	VBP
cord-006439-q7m4srvp	53	7	described	describe	VBN
cord-006439-q7m4srvp	53	8	the	the	DT
cord-006439-q7m4srvp	53	9	existence	existence	NN
cord-006439-q7m4srvp	53	10	of	of	IN
cord-006439-q7m4srvp	53	11	an	an	DT
cord-006439-q7m4srvp	53	12	alternative	alternative	JJ
cord-006439-q7m4srvp	53	13	renin	renin	NN
cord-006439-q7m4srvp	53	14	isoform	isoform	NN
cord-006439-q7m4srvp	53	15	termed	term	VBD
cord-006439-q7m4srvp	53	16	renin	renin	NN
cord-006439-q7m4srvp	53	17	-	-	HYPH
cord-006439-q7m4srvp	53	18	b	b	NN
cord-006439-q7m4srvp	53	19	,	,	,
cord-006439-q7m4srvp	53	20	which	which	WDT
cord-006439-q7m4srvp	53	21	is	be	VBZ
cord-006439-q7m4srvp	53	22	the	the	DT
cord-006439-q7m4srvp	53	23	predominant	predominant	JJ
cord-006439-q7m4srvp	53	24	transcribed	transcribe	VBN
cord-006439-q7m4srvp	53	25	renin	renin	NN
cord-006439-q7m4srvp	53	26	isoform	isoform	NN
cord-006439-q7m4srvp	53	27	in	in	IN
cord-006439-q7m4srvp	53	28	the	the	DT
cord-006439-q7m4srvp	53	29	brain	brain	NN
cord-006439-q7m4srvp	53	30	,	,	,
cord-006439-q7m4srvp	53	31	but	but	CC
cord-006439-q7m4srvp	53	32	is	be	VBZ
cord-006439-q7m4srvp	53	33	absent	absent	JJ
cord-006439-q7m4srvp	53	34	in	in	IN
cord-006439-q7m4srvp	53	35	other	other	JJ
cord-006439-q7m4srvp	53	36	tissues	tissue	NNS
cord-006439-q7m4srvp	53	37	[	[	-LRB-
cord-006439-q7m4srvp	53	38	41	41	CD
cord-006439-q7m4srvp	53	39	,	,	,
cord-006439-q7m4srvp	53	40	42	42	CD
cord-006439-q7m4srvp	53	41	]	]	-RRB-
cord-006439-q7m4srvp	53	42	.	.	.
cord-006439-q7m4srvp	54	1	Renin	renin	NN
cord-006439-q7m4srvp	54	2	-	-	HYPH
cord-006439-q7m4srvp	54	3	b	b	NNP
cord-006439-q7m4srvp	54	4	lacks	lack	VBZ
cord-006439-q7m4srvp	54	5	the	the	DT
cord-006439-q7m4srvp	54	6	signal	signal	NN
cord-006439-q7m4srvp	54	7	peptide	peptide	NN
cord-006439-q7m4srvp	54	8	and	and	CC
cord-006439-q7m4srvp	54	9	the	the	DT
cord-006439-q7m4srvp	54	10	first	first	JJ
cord-006439-q7m4srvp	54	11	third	third	NN
cord-006439-q7m4srvp	54	12	of	of	IN
cord-006439-q7m4srvp	54	13	the	the	DT
cord-006439-q7m4srvp	54	14	pro	pro	JJ
cord-006439-q7m4srvp	54	15	-	-	JJ
cord-006439-q7m4srvp	54	16	segment	segment	NN
cord-006439-q7m4srvp	54	17	which	which	WDT
cord-006439-q7m4srvp	54	18	implies	imply	VBZ
cord-006439-q7m4srvp	54	19	that	that	IN
cord-006439-q7m4srvp	54	20	(	(	-LRB-
cord-006439-q7m4srvp	54	21	1	1	CD
cord-006439-q7m4srvp	54	22	)	)	-RRB-
cord-006439-q7m4srvp	54	23	renin	renin	NN
cord-006439-q7m4srvp	54	24	-	-	HYPH
cord-006439-q7m4srvp	54	25	b	b	NN
cord-006439-q7m4srvp	54	26	protein	protein	NN
cord-006439-q7m4srvp	54	27	is	be	VBZ
cord-006439-q7m4srvp	54	28	catalytically	catalytically	RB
cord-006439-q7m4srvp	54	29	active	active	JJ
cord-006439-q7m4srvp	54	30	and	and	CC
cord-006439-q7m4srvp	54	31	(	(	-LRB-
cord-006439-q7m4srvp	54	32	2	2	LS
cord-006439-q7m4srvp	54	33	)	)	-RRB-
cord-006439-q7m4srvp	54	34	is	be	VBZ
cord-006439-q7m4srvp	54	35	predicted	predict	VBN
cord-006439-q7m4srvp	54	36	to	to	TO
cord-006439-q7m4srvp	54	37	remain	remain	VB
cord-006439-q7m4srvp	54	38	in	in	IN
cord-006439-q7m4srvp	54	39	an	an	DT
cord-006439-q7m4srvp	54	40	intracellular	intracellular	JJ
cord-006439-q7m4srvp	54	41	compartment	compartment	NN
cord-006439-q7m4srvp	54	42	[	[	-LRB-
cord-006439-q7m4srvp	54	43	43	43	CD
cord-006439-q7m4srvp	54	44	]	]	-RRB-
cord-006439-q7m4srvp	54	45	.	.	.
cord-006439-q7m4srvp	55	1	This	this	DT
cord-006439-q7m4srvp	55	2	observation	observation	NN
cord-006439-q7m4srvp	55	3	was	be	VBD
cord-006439-q7m4srvp	55	4	particularly	particularly	RB
cord-006439-q7m4srvp	55	5	compelling	compelling	JJ
cord-006439-q7m4srvp	55	6	as	as	IN
cord-006439-q7m4srvp	55	7	an	an	DT
cord-006439-q7m4srvp	55	8	intracrine	intracrine	NNP
cord-006439-q7m4srvp	55	9	RAS	RAS	NNP
cord-006439-q7m4srvp	55	10	had	have	VBD
cord-006439-q7m4srvp	55	11	been	be	VBN
cord-006439-q7m4srvp	55	12	previously	previously	RB
cord-006439-q7m4srvp	55	13	proposed	propose	VBN
cord-006439-q7m4srvp	55	14	[	[	-LRB-
cord-006439-q7m4srvp	55	15	44	44	CD
cord-006439-q7m4srvp	55	16	,	,	,
cord-006439-q7m4srvp	55	17	45	45	CD
cord-006439-q7m4srvp	55	18	]	]	-RRB-
cord-006439-q7m4srvp	55	19	.	.	.
cord-006439-q7m4srvp	56	1	Notably	notably	RB
cord-006439-q7m4srvp	56	2	,	,	,
cord-006439-q7m4srvp	56	3	evidence	evidence	NN
cord-006439-q7m4srvp	56	4	that	that	IN
cord-006439-q7m4srvp	56	5	ANG	ANG	NNP
cord-006439-q7m4srvp	56	6	-	-	HYPH
cord-006439-q7m4srvp	56	7	II	II	NNP
cord-006439-q7m4srvp	56	8	can	can	MD
cord-006439-q7m4srvp	56	9	be	be	VB
cord-006439-q7m4srvp	56	10	generated	generate	VBN
cord-006439-q7m4srvp	56	11	intracellularly	intracellularly	RB
cord-006439-q7m4srvp	56	12	in	in	IN
cord-006439-q7m4srvp	56	13	presynaptic	presynaptic	JJ
cord-006439-q7m4srvp	56	14	neurons	neuron	NNS
cord-006439-q7m4srvp	56	15	and	and	CC
cord-006439-q7m4srvp	56	16	subsequently	subsequently	RB
cord-006439-q7m4srvp	56	17	released	release	VBN
cord-006439-q7m4srvp	56	18	to	to	IN
cord-006439-q7m4srvp	56	19	the	the	DT
cord-006439-q7m4srvp	56	20	synaptic	synaptic	JJ
cord-006439-q7m4srvp	56	21	terminal	terminal	NN
cord-006439-q7m4srvp	56	22	upon	upon	IN
cord-006439-q7m4srvp	56	23	presynaptic	presynaptic	JJ
cord-006439-q7m4srvp	56	24	depolarization	depolarization	NN
cord-006439-q7m4srvp	56	25	would	would	MD
cord-006439-q7m4srvp	56	26	provide	provide	VB
cord-006439-q7m4srvp	56	27	a	a	DT
cord-006439-q7m4srvp	56	28	strong	strong	JJ
cord-006439-q7m4srvp	56	29	argument	argument	NN
cord-006439-q7m4srvp	56	30	to	to	TO
cord-006439-q7m4srvp	56	31	define	define	VB
cord-006439-q7m4srvp	56	32	ANG	ANG	NNP
cord-006439-q7m4srvp	56	33	-	-	HYPH
cord-006439-q7m4srvp	56	34	II	II	NNP
cord-006439-q7m4srvp	56	35	as	as	IN
cord-006439-q7m4srvp	56	36	a	a	DT
cord-006439-q7m4srvp	56	37	neurotransmitter	neurotransmitter	NN
cord-006439-q7m4srvp	56	38	.	.	.
cord-006439-q7m4srvp	57	1	To	to	TO
cord-006439-q7m4srvp	57	2	test	test	VB
cord-006439-q7m4srvp	57	3	the	the	DT
cord-006439-q7m4srvp	57	4	hypothesis	hypothesis	NN
cord-006439-q7m4srvp	57	5	that	that	IN
cord-006439-q7m4srvp	57	6	renin	renin	NN
cord-006439-q7m4srvp	57	7	-	-	HYPH
cord-006439-q7m4srvp	57	8	b	b	NN
cord-006439-q7m4srvp	57	9	is	be	VBZ
cord-006439-q7m4srvp	57	10	involved	involve	VBN
cord-006439-q7m4srvp	57	11	in	in	IN
cord-006439-q7m4srvp	57	12	the	the	DT
cord-006439-q7m4srvp	57	13	generation	generation	NN
cord-006439-q7m4srvp	57	14	of	of	IN
cord-006439-q7m4srvp	57	15	intracellular	intracellular	JJ
cord-006439-q7m4srvp	57	16	ANG	ANG	NNP
cord-006439-q7m4srvp	57	17	-	-	HYPH
cord-006439-q7m4srvp	57	18	II	II	NNP
cord-006439-q7m4srvp	57	19	in	in	IN
cord-006439-q7m4srvp	57	20	the	the	DT
cord-006439-q7m4srvp	57	21	brain	brain	NN
cord-006439-q7m4srvp	57	22	,	,	,
cord-006439-q7m4srvp	57	23	we	-PRON-	PRP
cord-006439-q7m4srvp	57	24	generated	generate	VBD
cord-006439-q7m4srvp	57	25	transgenic	transgenic	JJ
cord-006439-q7m4srvp	57	26	mice	mouse	NNS
cord-006439-q7m4srvp	57	27	lacking	lack	VBG
cord-006439-q7m4srvp	57	28	the	the	DT
cord-006439-q7m4srvp	57	29	alternative	alternative	JJ
cord-006439-q7m4srvp	57	30	renin	renin	NN
cord-006439-q7m4srvp	57	31	-	-	HYPH
cord-006439-q7m4srvp	57	32	b	b	NN
cord-006439-q7m4srvp	57	33	,	,	,
cord-006439-q7m4srvp	57	34	while	while	IN
cord-006439-q7m4srvp	57	35	renin	renin	NN
cord-006439-q7m4srvp	57	36	-	-	:
cord-006439-q7m4srvp	57	37	a	a	NN
cord-006439-q7m4srvp	57	38	was	be	VBD
cord-006439-q7m4srvp	57	39	preserved	preserve	VBN
cord-006439-q7m4srvp	57	40	[	[	-LRB-
cord-006439-q7m4srvp	57	41	46	46	CD
cord-006439-q7m4srvp	57	42	]	]	-RRB-
cord-006439-q7m4srvp	57	43	.	.	.
cord-006439-q7m4srvp	58	1	Paradoxically	paradoxically	RB
cord-006439-q7m4srvp	58	2	,	,	,
cord-006439-q7m4srvp	58	3	mice	mouse	NNS
cord-006439-q7m4srvp	58	4	lacking	lack	VBG
cord-006439-q7m4srvp	58	5	renin	renin	NN
cord-006439-q7m4srvp	58	6	-	-	HYPH
cord-006439-q7m4srvp	58	7	b	b	NN
cord-006439-q7m4srvp	58	8	exhibited	exhibit	VBD
cord-006439-q7m4srvp	58	9	a	a	DT
cord-006439-q7m4srvp	58	10	mild	mild	JJ
cord-006439-q7m4srvp	58	11	increase	increase	NN
cord-006439-q7m4srvp	58	12	in	in	IN
cord-006439-q7m4srvp	58	13	blood	blood	NN
cord-006439-q7m4srvp	58	14	pressure	pressure	NN
cord-006439-q7m4srvp	58	15	during	during	IN
cord-006439-q7m4srvp	58	16	the	the	DT
cord-006439-q7m4srvp	58	17	light	light	JJ
cord-006439-q7m4srvp	58	18	cycle	cycle	NN
cord-006439-q7m4srvp	58	19	,	,	,
cord-006439-q7m4srvp	58	20	which	which	WDT
cord-006439-q7m4srvp	58	21	was	be	VBD
cord-006439-q7m4srvp	58	22	attenuated	attenuate	VBN
cord-006439-q7m4srvp	58	23	by	by	IN
cord-006439-q7m4srvp	58	24	intracerebroventricular	intracerebroventricular	JJ
cord-006439-q7m4srvp	58	25	infusions	infusion	NNS
cord-006439-q7m4srvp	58	26	of	of	IN
cord-006439-q7m4srvp	58	27	AT	at	NN
cord-006439-q7m4srvp	58	28	1	1	CD
cord-006439-q7m4srvp	58	29	R	r	NN
cord-006439-q7m4srvp	58	30	blockers	blocker	NNS
cord-006439-q7m4srvp	58	31	or	or	CC
cord-006439-q7m4srvp	58	32	ACE	ace	NN
cord-006439-q7m4srvp	58	33	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	58	34	[	[	-LRB-
cord-006439-q7m4srvp	58	35	47•	47•	CD
cord-006439-q7m4srvp	58	36	]	]	-RRB-
cord-006439-q7m4srvp	58	37	.	.	.
cord-006439-q7m4srvp	59	1	These	these	DT
cord-006439-q7m4srvp	59	2	data	datum	NNS
cord-006439-q7m4srvp	59	3	indicate	indicate	VBP
cord-006439-q7m4srvp	59	4	that	that	IN
cord-006439-q7m4srvp	59	5	intracellular	intracellular	JJ
cord-006439-q7m4srvp	59	6	renin	renin	NN
cord-006439-q7m4srvp	59	7	-	-	HYPH
cord-006439-q7m4srvp	59	8	b	b	NN
cord-006439-q7m4srvp	59	9	might	may	MD
cord-006439-q7m4srvp	59	10	play	play	VB
cord-006439-q7m4srvp	59	11	a	a	DT
cord-006439-q7m4srvp	59	12	regulatory	regulatory	JJ
cord-006439-q7m4srvp	59	13	role	role	NN
cord-006439-q7m4srvp	59	14	on	on	IN
cord-006439-q7m4srvp	59	15	the	the	DT
cord-006439-q7m4srvp	59	16	brain	brain	NN
cord-006439-q7m4srvp	59	17	RAS	RAS	NNP
cord-006439-q7m4srvp	59	18	rather	rather	RB
cord-006439-q7m4srvp	59	19	than	than	IN
cord-006439-q7m4srvp	59	20	generating	generate	VBG
cord-006439-q7m4srvp	59	21	intracellular	intracellular	JJ
cord-006439-q7m4srvp	59	22	ANG	ANG	NNP
cord-006439-q7m4srvp	59	23	-	-	HYPH
cord-006439-q7m4srvp	59	24	II	II	NNP
cord-006439-q7m4srvp	59	25	as	as	IN
cord-006439-q7m4srvp	59	26	initially	initially	RB
cord-006439-q7m4srvp	59	27	proposed	propose	VBD
cord-006439-q7m4srvp	59	28	[	[	-LRB-
cord-006439-q7m4srvp	59	29	46	46	CD
cord-006439-q7m4srvp	59	30	]	]	-RRB-
cord-006439-q7m4srvp	59	31	.	.	.
cord-006439-q7m4srvp	60	1	Even	even	RB
cord-006439-q7m4srvp	60	2	though	though	IN
cord-006439-q7m4srvp	60	3	our	-PRON-	PRP$
cord-006439-q7m4srvp	60	4	data	datum	NNS
cord-006439-q7m4srvp	60	5	do	do	VBP
cord-006439-q7m4srvp	60	6	not	not	RB
cord-006439-q7m4srvp	60	7	support	support	VB
cord-006439-q7m4srvp	60	8	the	the	DT
cord-006439-q7m4srvp	60	9	existence	existence	NN
cord-006439-q7m4srvp	60	10	of	of	IN
cord-006439-q7m4srvp	60	11	an	an	DT
cord-006439-q7m4srvp	60	12	intracellular	intracellular	JJ
cord-006439-q7m4srvp	60	13	ANG	ANG	NNP
cord-006439-q7m4srvp	60	14	-	-	HYPH
cord-006439-q7m4srvp	60	15	II	II	NNP
cord-006439-q7m4srvp	60	16	generating	generating	NN
cord-006439-q7m4srvp	60	17	mechanism	mechanism	NN
cord-006439-q7m4srvp	60	18	,	,	,
cord-006439-q7m4srvp	60	19	they	-PRON-	PRP
cord-006439-q7m4srvp	60	20	neither	neither	CC
cord-006439-q7m4srvp	60	21	disprove	disprove	VBP
cord-006439-q7m4srvp	60	22	it	-PRON-	PRP
cord-006439-q7m4srvp	60	23	.	.	.
cord-006439-q7m4srvp	61	1	The	the	DT
cord-006439-q7m4srvp	61	2	brain	brain	NN
cord-006439-q7m4srvp	61	3	is	be	VBZ
cord-006439-q7m4srvp	61	4	one	one	CD
cord-006439-q7m4srvp	61	5	of	of	IN
cord-006439-q7m4srvp	61	6	the	the	DT
cord-006439-q7m4srvp	61	7	most	most	RBS
cord-006439-q7m4srvp	61	8	vascularized	vascularized	JJ
cord-006439-q7m4srvp	61	9	systems	system	NNS
cord-006439-q7m4srvp	61	10	because	because	IN
cord-006439-q7m4srvp	61	11	it	-PRON-	PRP
cord-006439-q7m4srvp	61	12	receives	receive	VBZ
cord-006439-q7m4srvp	61	13	8.6	8.6	CD
cord-006439-q7m4srvp	61	14	-	-	HYPH
cord-006439-q7m4srvp	61	15	20.4	20.4	CD
cord-006439-q7m4srvp	61	16	%	%	NN
cord-006439-q7m4srvp	61	17	of	of	IN
cord-006439-q7m4srvp	61	18	total	total	JJ
cord-006439-q7m4srvp	61	19	cardiac	cardiac	JJ
cord-006439-q7m4srvp	61	20	output	output	NN
cord-006439-q7m4srvp	61	21	;	;	:
cord-006439-q7m4srvp	61	22	thus	thus	RB
cord-006439-q7m4srvp	61	23	,	,	,
cord-006439-q7m4srvp	61	24	distinguishing	distinguish	VBG
cord-006439-q7m4srvp	61	25	renin	renin	NN
cord-006439-q7m4srvp	61	26	levels	level	NNS
cord-006439-q7m4srvp	61	27	generated	generate	VBN
cord-006439-q7m4srvp	61	28	within	within	IN
cord-006439-q7m4srvp	61	29	brain	brain	NN
cord-006439-q7m4srvp	61	30	tissues	tissue	NNS
cord-006439-q7m4srvp	61	31	(	(	-LRB-
cord-006439-q7m4srvp	61	32	autocrine	autocrine	NN
cord-006439-q7m4srvp	61	33	/	/	SYM
cord-006439-q7m4srvp	61	34	paracrine	paracrine	NN
cord-006439-q7m4srvp	61	35	)	)	-RRB-
cord-006439-q7m4srvp	61	36	from	from	IN
cord-006439-q7m4srvp	61	37	the	the	DT
cord-006439-q7m4srvp	61	38	circulating	circulate	VBG
cord-006439-q7m4srvp	61	39	renin	renin	NN
cord-006439-q7m4srvp	61	40	(	(	-LRB-
cord-006439-q7m4srvp	61	41	endocrine	endocrine	NN
cord-006439-q7m4srvp	61	42	)	)	-RRB-
cord-006439-q7m4srvp	61	43	is	be	VBZ
cord-006439-q7m4srvp	61	44	extremely	extremely	RB
cord-006439-q7m4srvp	61	45	challenging	challenging	JJ
cord-006439-q7m4srvp	61	46	[	[	-LRB-
cord-006439-q7m4srvp	61	47	48	48	CD
cord-006439-q7m4srvp	61	48	]	]	-RRB-
cord-006439-q7m4srvp	61	49	.	.	.
cord-006439-q7m4srvp	62	1	Despite	despite	IN
cord-006439-q7m4srvp	62	2	evidence	evidence	NN
cord-006439-q7m4srvp	62	3	that	that	IN
cord-006439-q7m4srvp	62	4	renin	renin	NN
cord-006439-q7m4srvp	62	5	activity	activity	NN
cord-006439-q7m4srvp	62	6	and	and	CC
cord-006439-q7m4srvp	62	7	ANG	ANG	NNP
cord-006439-q7m4srvp	62	8	-	-	HYPH
cord-006439-q7m4srvp	62	9	II	II	NNP
cord-006439-q7m4srvp	62	10	have	have	VBP
cord-006439-q7m4srvp	62	11	been	be	VBN
cord-006439-q7m4srvp	62	12	identified	identify	VBN
cord-006439-q7m4srvp	62	13	in	in	IN
cord-006439-q7m4srvp	62	14	the	the	DT
cord-006439-q7m4srvp	62	15	cerebrospinal	cerebrospinal	JJ
cord-006439-q7m4srvp	62	16	fluid	fluid	NN
cord-006439-q7m4srvp	62	17	(	(	-LRB-
cord-006439-q7m4srvp	62	18	CSF	CSF	NNP
cord-006439-q7m4srvp	62	19	)	)	-RRB-
cord-006439-q7m4srvp	62	20	and	and	CC
cord-006439-q7m4srvp	62	21	brain	brain	NN
cord-006439-q7m4srvp	62	22	tissues	tissue	NNS
cord-006439-q7m4srvp	62	23	from	from	IN
cord-006439-q7m4srvp	62	24	nephrectomized	nephrectomized	JJ
cord-006439-q7m4srvp	62	25	animals	animal	NNS
cord-006439-q7m4srvp	62	26	,	,	,
cord-006439-q7m4srvp	62	27	those	those	DT
cord-006439-q7m4srvp	62	28	who	who	WP
cord-006439-q7m4srvp	62	29	resist	resist	VBP
cord-006439-q7m4srvp	62	30	the	the	DT
cord-006439-q7m4srvp	62	31	existence	existence	NN
cord-006439-q7m4srvp	62	32	of	of	IN
cord-006439-q7m4srvp	62	33	the	the	DT
cord-006439-q7m4srvp	62	34	brain	brain	NN
cord-006439-q7m4srvp	62	35	RAS	RAS	NNP
cord-006439-q7m4srvp	62	36	postulated	postulate	VBD
cord-006439-q7m4srvp	62	37	that	that	IN
cord-006439-q7m4srvp	62	38	samples	sample	NNS
cord-006439-q7m4srvp	62	39	must	must	MD
cord-006439-q7m4srvp	62	40	be	be	VB
cord-006439-q7m4srvp	62	41	contaminated	contaminate	VBN
cord-006439-q7m4srvp	62	42	with	with	IN
cord-006439-q7m4srvp	62	43	traces	trace	NNS
cord-006439-q7m4srvp	62	44	of	of	IN
cord-006439-q7m4srvp	62	45	trapped	trap	VBN
cord-006439-q7m4srvp	62	46	blood	blood	NN
cord-006439-q7m4srvp	62	47	[	[	-LRB-
cord-006439-q7m4srvp	62	48	49	49	CD
cord-006439-q7m4srvp	62	49	]	]	-RRB-
cord-006439-q7m4srvp	62	50	[	[	-LRB-
cord-006439-q7m4srvp	62	51	50	50	CD
cord-006439-q7m4srvp	62	52	]	]	-RRB-
cord-006439-q7m4srvp	62	53	[	[	-LRB-
cord-006439-q7m4srvp	62	54	51	51	CD
cord-006439-q7m4srvp	62	55	]	]	-RRB-
cord-006439-q7m4srvp	62	56	[	[	-LRB-
cord-006439-q7m4srvp	62	57	52	52	CD
cord-006439-q7m4srvp	62	58	]	]	-RRB-
cord-006439-q7m4srvp	62	59	[	[	-LRB-
cord-006439-q7m4srvp	62	60	53	53	CD
cord-006439-q7m4srvp	62	61	]	]	-RRB-
cord-006439-q7m4srvp	62	62	[	[	-LRB-
cord-006439-q7m4srvp	62	63	54	54	CD
cord-006439-q7m4srvp	62	64	]	]	-RRB-
cord-006439-q7m4srvp	62	65	[	[	-LRB-
cord-006439-q7m4srvp	62	66	55	55	CD
cord-006439-q7m4srvp	62	67	]	]	-RRB-
cord-006439-q7m4srvp	62	68	[	[	-LRB-
cord-006439-q7m4srvp	62	69	56	56	CD
cord-006439-q7m4srvp	62	70	]	]	-RRB-
cord-006439-q7m4srvp	62	71	[	[	-LRB-
cord-006439-q7m4srvp	62	72	57	57	CD
cord-006439-q7m4srvp	62	73	]	]	-RRB-
cord-006439-q7m4srvp	62	74	.	.	.
cord-006439-q7m4srvp	63	1	Following	follow	VBG
cord-006439-q7m4srvp	63	2	this	this	DT
cord-006439-q7m4srvp	63	3	rationale	rationale	NN
cord-006439-q7m4srvp	63	4	,	,	,
cord-006439-q7m4srvp	63	5	Van	Van	NNP
cord-006439-q7m4srvp	63	6	Thiel	Thiel	NNP
cord-006439-q7m4srvp	63	7	and	and	CC
cord-006439-q7m4srvp	63	8	colleagues	colleague	NNS
cord-006439-q7m4srvp	63	9	attempted	attempt	VBD
cord-006439-q7m4srvp	63	10	to	to	TO
cord-006439-q7m4srvp	63	11	provide	provide	VB
cord-006439-q7m4srvp	63	12	evidence	evidence	NN
cord-006439-q7m4srvp	63	13	that	that	IN
cord-006439-q7m4srvp	63	14	the	the	DT
cord-006439-q7m4srvp	63	15	brain	brain	NN
cord-006439-q7m4srvp	63	16	lacks	lack	VBZ
cord-006439-q7m4srvp	63	17	the	the	DT
cord-006439-q7m4srvp	63	18	capacity	capacity	NN
cord-006439-q7m4srvp	63	19	to	to	TO
cord-006439-q7m4srvp	63	20	generate	generate	VB
cord-006439-q7m4srvp	63	21	ANG	ANG	NNP
cord-006439-q7m4srvp	63	22	-	-	HYPH
cord-006439-q7m4srvp	63	23	II	II	NNP
cord-006439-q7m4srvp	63	24	by	by	IN
cord-006439-q7m4srvp	63	25	measuring	measure	VBG
cord-006439-q7m4srvp	63	26	renin	renin	NN
cord-006439-q7m4srvp	63	27	activity	activity	NN
cord-006439-q7m4srvp	63	28	(	(	-LRB-
cord-006439-q7m4srvp	63	29	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	63	30	-	-	HYPH
cord-006439-q7m4srvp	63	31	generating	generate	VBG
cord-006439-q7m4srvp	63	32	activity	activity	NN
cord-006439-q7m4srvp	63	33	)	)	-RRB-
cord-006439-q7m4srvp	63	34	in	in	IN
cord-006439-q7m4srvp	63	35	brain	brain	NN
cord-006439-q7m4srvp	63	36	structures	structure	NNS
cord-006439-q7m4srvp	63	37	before	before	IN
cord-006439-q7m4srvp	63	38	and	and	CC
cord-006439-q7m4srvp	63	39	after	after	IN
cord-006439-q7m4srvp	63	40	organ	organ	NN
cord-006439-q7m4srvp	63	41	buffer	buffer	NN
cord-006439-q7m4srvp	63	42	perfusion	perfusion	NN
cord-006439-q7m4srvp	63	43	[	[	-LRB-
cord-006439-q7m4srvp	63	44	37	37	CD
cord-006439-q7m4srvp	63	45	]	]	-RRB-
cord-006439-q7m4srvp	63	46	.	.	.
cord-006439-q7m4srvp	64	1	It	-PRON-	PRP
cord-006439-q7m4srvp	64	2	is	be	VBZ
cord-006439-q7m4srvp	64	3	not	not	RB
cord-006439-q7m4srvp	64	4	surprising	surprising	JJ
cord-006439-q7m4srvp	64	5	that	that	IN
cord-006439-q7m4srvp	64	6	there	there	EX
cord-006439-q7m4srvp	64	7	was	be	VBD
cord-006439-q7m4srvp	64	8	a	a	DT
cord-006439-q7m4srvp	64	9	significant	significant	JJ
cord-006439-q7m4srvp	64	10	decrease	decrease	NN
cord-006439-q7m4srvp	64	11	in	in	IN
cord-006439-q7m4srvp	64	12	renin	renin	NN
cord-006439-q7m4srvp	64	13	activity	activity	NN
cord-006439-q7m4srvp	64	14	within	within	IN
cord-006439-q7m4srvp	64	15	several	several	JJ
cord-006439-q7m4srvp	64	16	brain	brain	NN
cord-006439-q7m4srvp	64	17	structures	structure	NNS
cord-006439-q7m4srvp	64	18	after	after	IN
cord-006439-q7m4srvp	64	19	buffer	buffer	NN
cord-006439-q7m4srvp	64	20	perfusion	perfusion	NN
cord-006439-q7m4srvp	64	21	because	because	IN
cord-006439-q7m4srvp	64	22	(	(	-LRB-
cord-006439-q7m4srvp	64	23	1	1	LS
cord-006439-q7m4srvp	64	24	)	)	-RRB-
cord-006439-q7m4srvp	64	25	the	the	DT
cord-006439-q7m4srvp	64	26	brain	brain	NN
cord-006439-q7m4srvp	64	27	has	have	VBZ
cord-006439-q7m4srvp	64	28	blood	blood	NN
cord-006439-q7m4srvp	64	29	,	,	,
cord-006439-q7m4srvp	64	30	and	and	CC
cord-006439-q7m4srvp	64	31	(	(	-LRB-
cord-006439-q7m4srvp	64	32	2	2	LS
cord-006439-q7m4srvp	64	33	)	)	-RRB-
cord-006439-q7m4srvp	64	34	neurons	neuron	NNS
cord-006439-q7m4srvp	64	35	unlikely	unlikely	JJ
cord-006439-q7m4srvp	64	36	store	store	NN
cord-006439-q7m4srvp	64	37	renin	renin	NN
cord-006439-q7m4srvp	64	38	within	within	IN
cord-006439-q7m4srvp	64	39	granules	granule	NNS
cord-006439-q7m4srvp	64	40	as	as	IN
cord-006439-q7m4srvp	64	41	do	do	VBP
cord-006439-q7m4srvp	64	42	specialized	specialized	JJ
cord-006439-q7m4srvp	64	43	renal	renal	JJ
cord-006439-q7m4srvp	64	44	juxtaglomerular	juxtaglomerular	JJ
cord-006439-q7m4srvp	64	45	cells	cell	NNS
cord-006439-q7m4srvp	64	46	.	.	.
cord-006439-q7m4srvp	65	1	Indeed	indeed	RB
cord-006439-q7m4srvp	65	2	,	,	,
cord-006439-q7m4srvp	65	3	the	the	DT
cord-006439-q7m4srvp	65	4	most	most	RBS
cord-006439-q7m4srvp	65	5	direct	direct	JJ
cord-006439-q7m4srvp	65	6	and	and	CC
cord-006439-q7m4srvp	65	7	accurate	accurate	JJ
cord-006439-q7m4srvp	65	8	conclusion	conclusion	NN
cord-006439-q7m4srvp	65	9	from	from	IN
cord-006439-q7m4srvp	65	10	this	this	DT
cord-006439-q7m4srvp	65	11	study	study	NN
cord-006439-q7m4srvp	65	12	was	be	VBD
cord-006439-q7m4srvp	65	13	that	that	IN
cord-006439-q7m4srvp	65	14	the	the	DT
cord-006439-q7m4srvp	65	15	brain	brain	NN
cord-006439-q7m4srvp	65	16	indeed	indeed	RB
cord-006439-q7m4srvp	65	17	contains	contain	VBZ
cord-006439-q7m4srvp	65	18	blood	blood	NN
cord-006439-q7m4srvp	65	19	.	.	.
cord-006439-q7m4srvp	66	1	It	-PRON-	PRP
cord-006439-q7m4srvp	66	2	is	be	VBZ
cord-006439-q7m4srvp	66	3	surprising	surprise	VBG
cord-006439-q7m4srvp	66	4	the	the	DT
cord-006439-q7m4srvp	66	5	authors	author	NNS
cord-006439-q7m4srvp	66	6	decided	decide	VBD
cord-006439-q7m4srvp	66	7	to	to	TO
cord-006439-q7m4srvp	66	8	ignore	ignore	VB
cord-006439-q7m4srvp	66	9	their	-PRON-	PRP$
cord-006439-q7m4srvp	66	10	own	own	JJ
cord-006439-q7m4srvp	66	11	data	datum	NNS
cord-006439-q7m4srvp	66	12	that	that	IN
cord-006439-q7m4srvp	66	13	renin	renin	NN
cord-006439-q7m4srvp	66	14	activity	activity	NN
cord-006439-q7m4srvp	66	15	remained	remain	VBD
cord-006439-q7m4srvp	66	16	at	at	IN
cord-006439-q7m4srvp	66	17	detectable	detectable	JJ
cord-006439-q7m4srvp	66	18	levels	level	NNS
cord-006439-q7m4srvp	66	19	in	in	IN
cord-006439-q7m4srvp	66	20	some	some	DT
cord-006439-q7m4srvp	66	21	buffer	buffer	NN
cord-006439-q7m4srvp	66	22	-	-	HYPH
cord-006439-q7m4srvp	66	23	perfused	perfuse	VBN
cord-006439-q7m4srvp	66	24	tissues	tissue	NNS
cord-006439-q7m4srvp	66	25	including	include	VBG
cord-006439-q7m4srvp	66	26	the	the	DT
cord-006439-q7m4srvp	66	27	brainstem	brainstem	NN
cord-006439-q7m4srvp	66	28	.	.	.
cord-006439-q7m4srvp	67	1	This	this	DT
cord-006439-q7m4srvp	67	2	is	be	VBZ
cord-006439-q7m4srvp	67	3	particularly	particularly	RB
cord-006439-q7m4srvp	67	4	interesting	interesting	JJ
cord-006439-q7m4srvp	67	5	because	because	IN
cord-006439-q7m4srvp	67	6	in	in	IN
cord-006439-q7m4srvp	67	7	a	a	DT
cord-006439-q7m4srvp	67	8	double	double	JJ
cord-006439-q7m4srvp	67	9	-	-	HYPH
cord-006439-q7m4srvp	67	10	transgenic	transgenic	JJ
cord-006439-q7m4srvp	67	11	mouse	mouse	NN
cord-006439-q7m4srvp	67	12	in	in	IN
cord-006439-q7m4srvp	67	13	which	which	WDT
cord-006439-q7m4srvp	67	14	enhanced	enhance	VBD
cord-006439-q7m4srvp	67	15	green	green	JJ
cord-006439-q7m4srvp	67	16	fluorescence	fluorescence	NN
cord-006439-q7m4srvp	67	17	protein	protein	NN
cord-006439-q7m4srvp	67	18	(	(	-LRB-
cord-006439-q7m4srvp	67	19	GFP	GFP	NNP
cord-006439-q7m4srvp	67	20	)	)	-RRB-
cord-006439-q7m4srvp	67	21	is	be	VBZ
cord-006439-q7m4srvp	67	22	expressed	express	VBN
cord-006439-q7m4srvp	67	23	under	under	IN
cord-006439-q7m4srvp	67	24	the	the	DT
cord-006439-q7m4srvp	67	25	control	control	NN
cord-006439-q7m4srvp	67	26	of	of	IN
cord-006439-q7m4srvp	67	27	the	the	DT
cord-006439-q7m4srvp	67	28	renin	renin	NN
cord-006439-q7m4srvp	67	29	promoter	promoter	NN
cord-006439-q7m4srvp	67	30	and	and	CC
cord-006439-q7m4srvp	67	31	β	β	NN
cord-006439-q7m4srvp	67	32	-	-	HYPH
cord-006439-q7m4srvp	67	33	galactosidase	galactosidase	NN
cord-006439-q7m4srvp	67	34	is	be	VBZ
cord-006439-q7m4srvp	67	35	controlled	control	VBN
cord-006439-q7m4srvp	67	36	by	by	IN
cord-006439-q7m4srvp	67	37	the	the	DT
cord-006439-q7m4srvp	67	38	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	67	39	promoter	promoter	NN
cord-006439-q7m4srvp	67	40	,	,	,
cord-006439-q7m4srvp	67	41	we	-PRON-	PRP
cord-006439-q7m4srvp	67	42	identified	identify	VBD
cord-006439-q7m4srvp	67	43	unique	unique	JJ
cord-006439-q7m4srvp	67	44	reninexpressing	reninexpressing	NN
cord-006439-q7m4srvp	67	45	cells	cell	NNS
cord-006439-q7m4srvp	67	46	in	in	IN
cord-006439-q7m4srvp	67	47	close	close	JJ
cord-006439-q7m4srvp	67	48	proximity	proximity	NN
cord-006439-q7m4srvp	67	49	to	to	IN
cord-006439-q7m4srvp	67	50	angiotensinogenexpressing	angiotensinogenexpressing	NN
cord-006439-q7m4srvp	67	51	cells	cell	NNS
cord-006439-q7m4srvp	67	52	specifically	specifically	RB
cord-006439-q7m4srvp	67	53	within	within	IN
cord-006439-q7m4srvp	67	54	the	the	DT
cord-006439-q7m4srvp	67	55	RVLM	RVLM	NNP
cord-006439-q7m4srvp	67	56	,	,	,
cord-006439-q7m4srvp	67	57	a	a	DT
cord-006439-q7m4srvp	67	58	brainstem	brainstem	NN
cord-006439-q7m4srvp	67	59	nucleus	nucleus	NN
cord-006439-q7m4srvp	67	60	[	[	-LRB-
cord-006439-q7m4srvp	67	61	58	58	CD
cord-006439-q7m4srvp	67	62	,	,	,
cord-006439-q7m4srvp	67	63	59	59	CD
cord-006439-q7m4srvp	67	64	]	]	-RRB-
cord-006439-q7m4srvp	67	65	.	.	.
cord-006439-q7m4srvp	68	1	It	-PRON-	PRP
cord-006439-q7m4srvp	68	2	is	be	VBZ
cord-006439-q7m4srvp	68	3	of	of	IN
cord-006439-q7m4srvp	68	4	utmost	utmost	JJ
cord-006439-q7m4srvp	68	5	importance	importance	NN
cord-006439-q7m4srvp	68	6	that	that	WDT
cord-006439-q7m4srvp	68	7	one	one	CD
cord-006439-q7m4srvp	68	8	contrasts	contrast	VBZ
cord-006439-q7m4srvp	68	9	a	a	DT
cord-006439-q7m4srvp	68	10	classical	classical	JJ
cord-006439-q7m4srvp	68	11	endocrine	endocrine	NN
cord-006439-q7m4srvp	68	12	system	system	NN
cord-006439-q7m4srvp	68	13	and	and	CC
cord-006439-q7m4srvp	68	14	views	view	VBZ
cord-006439-q7m4srvp	68	15	the	the	DT
cord-006439-q7m4srvp	68	16	brain	brain	NN
cord-006439-q7m4srvp	68	17	RAS	RAS	NNP
cord-006439-q7m4srvp	68	18	as	as	IN
cord-006439-q7m4srvp	68	19	a	a	DT
cord-006439-q7m4srvp	68	20	neuroendocrine	neuroendocrine	NN
cord-006439-q7m4srvp	68	21	,	,	,
cord-006439-q7m4srvp	68	22	autacoid	autacoid	JJ
cord-006439-q7m4srvp	68	23	,	,	,
cord-006439-q7m4srvp	68	24	or	or	CC
cord-006439-q7m4srvp	68	25	neurotransmitter	neurotransmitter	NN
cord-006439-q7m4srvp	68	26	system	system	NN
cord-006439-q7m4srvp	68	27	where	where	WRB
cord-006439-q7m4srvp	68	28	single	single	JJ
cord-006439-q7m4srvp	68	29	neurons	neuron	NNS
cord-006439-q7m4srvp	68	30	or	or	CC
cord-006439-q7m4srvp	68	31	small	small	JJ
cord-006439-q7m4srvp	68	32	collections	collection	NNS
cord-006439-q7m4srvp	68	33	of	of	IN
cord-006439-q7m4srvp	68	34	neurons	neuron	NNS
cord-006439-q7m4srvp	68	35	mediate	mediate	VBP
cord-006439-q7m4srvp	68	36	output	output	NN
cord-006439-q7m4srvp	68	37	from	from	IN
cord-006439-q7m4srvp	68	38	the	the	DT
cord-006439-q7m4srvp	68	39	CNS	CNS	NNP
cord-006439-q7m4srvp	68	40	.	.	.
cord-006439-q7m4srvp	69	1	Thus	thus	RB
cord-006439-q7m4srvp	69	2	,	,	,
cord-006439-q7m4srvp	69	3	cellular	cellular	JJ
cord-006439-q7m4srvp	69	4	,	,	,
cord-006439-q7m4srvp	69	5	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	69	6	,	,	,
cord-006439-q7m4srvp	69	7	and	and	CC
cord-006439-q7m4srvp	69	8	molecular	molecular	JJ
cord-006439-q7m4srvp	69	9	specificities	specificity	NNS
cord-006439-q7m4srvp	69	10	are	be	VBP
cord-006439-q7m4srvp	69	11	the	the	DT
cord-006439-q7m4srvp	69	12	key	key	JJ
cord-006439-q7m4srvp	69	13	aspects	aspect	NNS
cord-006439-q7m4srvp	69	14	to	to	TO
cord-006439-q7m4srvp	69	15	be	be	VB
cord-006439-q7m4srvp	69	16	considered	consider	VBN
cord-006439-q7m4srvp	69	17	when	when	WRB
cord-006439-q7m4srvp	69	18	neuroendocrine	neuroendocrine	JJ
cord-006439-q7m4srvp	69	19	systems	system	NNS
cord-006439-q7m4srvp	69	20	,	,	,
cord-006439-q7m4srvp	69	21	such	such	JJ
cord-006439-q7m4srvp	69	22	as	as	IN
cord-006439-q7m4srvp	69	23	the	the	DT
cord-006439-q7m4srvp	69	24	brain	brain	NN
cord-006439-q7m4srvp	69	25	RAS	RAS	NNP
cord-006439-q7m4srvp	69	26	,	,	,
cord-006439-q7m4srvp	69	27	are	be	VBP
cord-006439-q7m4srvp	69	28	studied	study	VBN
cord-006439-q7m4srvp	69	29	.	.	.
cord-006439-q7m4srvp	70	1	It	-PRON-	PRP
cord-006439-q7m4srvp	70	2	remains	remain	VBZ
cord-006439-q7m4srvp	70	3	unfortunate	unfortunate	JJ
cord-006439-q7m4srvp	70	4	that	that	IN
cord-006439-q7m4srvp	70	5	equivocal	equivocal	JJ
cord-006439-q7m4srvp	70	6	interpretations	interpretation	NNS
cord-006439-q7m4srvp	70	7	from	from	IN
cord-006439-q7m4srvp	70	8	experiments	experiment	NNS
cord-006439-q7m4srvp	70	9	lacking	lack	VBG
cord-006439-q7m4srvp	70	10	sensitivity	sensitivity	NN
cord-006439-q7m4srvp	70	11	and	and	CC
cord-006439-q7m4srvp	70	12	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	70	13	selectivity	selectivity	NN
cord-006439-q7m4srvp	70	14	,	,	,
cord-006439-q7m4srvp	70	15	those	those	DT
cord-006439-q7m4srvp	70	16	which	which	WDT
cord-006439-q7m4srvp	70	17	are	be	VBP
cord-006439-q7m4srvp	70	18	not	not	RB
cord-006439-q7m4srvp	70	19	required	require	VBN
cord-006439-q7m4srvp	70	20	when	when	WRB
cord-006439-q7m4srvp	70	21	studying	study	VBG
cord-006439-q7m4srvp	70	22	the	the	DT
cord-006439-q7m4srvp	70	23	classical	classical	JJ
cord-006439-q7m4srvp	70	24	RAS	RAS	NNP
cord-006439-q7m4srvp	70	25	,	,	,
cord-006439-q7m4srvp	70	26	re	re	NNS
cord-006439-q7m4srvp	70	27	-	-	NN
cord-006439-q7m4srvp	70	28	emerge	emerge	VB
cord-006439-q7m4srvp	70	29	from	from	IN
cord-006439-q7m4srvp	70	30	time	time	NN
cord-006439-q7m4srvp	70	31	to	to	IN
cord-006439-q7m4srvp	70	32	time	time	NN
cord-006439-q7m4srvp	70	33	to	to	TO
cord-006439-q7m4srvp	70	34	question	question	VB
cord-006439-q7m4srvp	70	35	the	the	DT
cord-006439-q7m4srvp	70	36	existence	existence	NN
cord-006439-q7m4srvp	70	37	of	of	IN
cord-006439-q7m4srvp	70	38	the	the	DT
cord-006439-q7m4srvp	70	39	brain	brain	NN
cord-006439-q7m4srvp	70	40	RAS	RAS	NNP
cord-006439-q7m4srvp	70	41	[	[	-LRB-
cord-006439-q7m4srvp	70	42	60	60	CD
cord-006439-q7m4srvp	70	43	]	]	-RRB-
cord-006439-q7m4srvp	70	44	.	.	.
cord-006439-q7m4srvp	71	1	In	in	IN
cord-006439-q7m4srvp	71	2	the	the	DT
cord-006439-q7m4srvp	71	3	final	final	JJ
cord-006439-q7m4srvp	71	4	section	section	NN
cord-006439-q7m4srvp	71	5	of	of	IN
cord-006439-q7m4srvp	71	6	this	this	DT
cord-006439-q7m4srvp	71	7	article	article	NN
cord-006439-q7m4srvp	71	8	,	,	,
cord-006439-q7m4srvp	71	9	we	-PRON-	PRP
cord-006439-q7m4srvp	71	10	will	will	MD
cord-006439-q7m4srvp	71	11	discuss	discuss	VB
cord-006439-q7m4srvp	71	12	how	how	WRB
cord-006439-q7m4srvp	71	13	the	the	DT
cord-006439-q7m4srvp	71	14	development	development	NN
cord-006439-q7m4srvp	71	15	of	of	IN
cord-006439-q7m4srvp	71	16	state	state	NN
cord-006439-q7m4srvp	71	17	-	-	HYPH
cord-006439-q7m4srvp	71	18	of	of	IN
cord-006439-q7m4srvp	71	19	-	-	HYPH
cord-006439-q7m4srvp	71	20	the	the	DT
cord-006439-q7m4srvp	71	21	-	-	HYPH
cord-006439-q7m4srvp	71	22	art	art	NN
cord-006439-q7m4srvp	71	23	technology	technology	NN
cord-006439-q7m4srvp	71	24	to	to	TO
cord-006439-q7m4srvp	71	25	study	study	VB
cord-006439-q7m4srvp	71	26	precise	precise	JJ
cord-006439-q7m4srvp	71	27	molecular	molecular	JJ
cord-006439-q7m4srvp	71	28	signaling	signaling	NN
cord-006439-q7m4srvp	71	29	and	and	CC
cord-006439-q7m4srvp	71	30	neuronal	neuronal	JJ
cord-006439-q7m4srvp	71	31	circuits	circuit	NNS
cord-006439-q7m4srvp	71	32	within	within	IN
cord-006439-q7m4srvp	71	33	the	the	DT
cord-006439-q7m4srvp	71	34	CNS	CNS	NNP
cord-006439-q7m4srvp	71	35	are	be	VBP
cord-006439-q7m4srvp	71	36	appropriate	appropriate	JJ
cord-006439-q7m4srvp	71	37	to	to	TO
cord-006439-q7m4srvp	71	38	elucidate	elucidate	VB
cord-006439-q7m4srvp	71	39	the	the	DT
cord-006439-q7m4srvp	71	40	key	key	JJ
cord-006439-q7m4srvp	71	41	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	71	42	regulating	regulate	VBG
cord-006439-q7m4srvp	71	43	generation	generation	NN
cord-006439-q7m4srvp	71	44	and	and	CC
cord-006439-q7m4srvp	71	45	action	action	NN
cord-006439-q7m4srvp	71	46	of	of	IN
cord-006439-q7m4srvp	71	47	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	71	48	peptides	peptide	NNS
cord-006439-q7m4srvp	71	49	within	within	IN
cord-006439-q7m4srvp	71	50	different	different	JJ
cord-006439-q7m4srvp	71	51	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	71	52	regions	region	NNS
cord-006439-q7m4srvp	71	53	.	.	.
cord-006439-q7m4srvp	72	1	The	the	DT
cord-006439-q7m4srvp	72	2	proteolytic	proteolytic	JJ
cord-006439-q7m4srvp	72	3	activation	activation	NN
cord-006439-q7m4srvp	72	4	of	of	IN
cord-006439-q7m4srvp	72	5	prorenin	prorenin	NN
cord-006439-q7m4srvp	72	6	that	that	WDT
cord-006439-q7m4srvp	72	7	normally	normally	RB
cord-006439-q7m4srvp	72	8	occurs	occur	VBZ
cord-006439-q7m4srvp	72	9	in	in	IN
cord-006439-q7m4srvp	72	10	secretory	secretory	JJ
cord-006439-q7m4srvp	72	11	granules	granule	NNS
cord-006439-q7m4srvp	72	12	in	in	IN
cord-006439-q7m4srvp	72	13	renal	renal	JJ
cord-006439-q7m4srvp	72	14	JG	JG	NNP
cord-006439-q7m4srvp	72	15	cells	cell	NNS
cord-006439-q7m4srvp	72	16	is	be	VBZ
cord-006439-q7m4srvp	72	17	unlikely	unlikely	JJ
cord-006439-q7m4srvp	72	18	to	to	TO
cord-006439-q7m4srvp	72	19	occur	occur	VB
cord-006439-q7m4srvp	72	20	in	in	IN
cord-006439-q7m4srvp	72	21	extrarenal	extrarenal	JJ
cord-006439-q7m4srvp	72	22	tissues	tissue	NNS
cord-006439-q7m4srvp	72	23	,	,	,
cord-006439-q7m4srvp	72	24	including	include	VBG
cord-006439-q7m4srvp	72	25	the	the	DT
cord-006439-q7m4srvp	72	26	brain	brain	NN
cord-006439-q7m4srvp	72	27	[	[	-LRB-
cord-006439-q7m4srvp	72	28	61	61	CD
cord-006439-q7m4srvp	72	29	]	]	-RRB-
cord-006439-q7m4srvp	72	30	.	.	.
cord-006439-q7m4srvp	73	1	Thus	thus	RB
cord-006439-q7m4srvp	73	2	,	,	,
cord-006439-q7m4srvp	73	3	it	-PRON-	PRP
cord-006439-q7m4srvp	73	4	has	have	VBZ
cord-006439-q7m4srvp	73	5	been	be	VBN
cord-006439-q7m4srvp	73	6	proposed	propose	VBN
cord-006439-q7m4srvp	73	7	that	that	DT
cord-006439-q7m4srvp	73	8	activation	activation	NN
cord-006439-q7m4srvp	73	9	of	of	IN
cord-006439-q7m4srvp	73	10	renin	renin	NN
cord-006439-q7m4srvp	73	11	in	in	IN
cord-006439-q7m4srvp	73	12	extrarenal	extrarenal	JJ
cord-006439-q7m4srvp	73	13	tissues	tissue	NNS
cord-006439-q7m4srvp	73	14	requires	require	VBZ
cord-006439-q7m4srvp	73	15	its	-PRON-	PRP$
cord-006439-q7m4srvp	73	16	binding	binding	NN
cord-006439-q7m4srvp	73	17	to	to	IN
cord-006439-q7m4srvp	73	18	ATPase	ATPase	NNP
cord-006439-q7m4srvp	73	19	H(+)-transporting	h(+)-transporte	VBG
cord-006439-q7m4srvp	73	20	lysosomal	lysosomal	JJ
cord-006439-q7m4srvp	73	21	accessory	accessory	NN
cord-006439-q7m4srvp	73	22	protein	protein	NN
cord-006439-q7m4srvp	73	23	2	2	CD
cord-006439-q7m4srvp	73	24	,	,	,
cord-006439-q7m4srvp	73	25	also	also	RB
cord-006439-q7m4srvp	73	26	known	know	VBN
cord-006439-q7m4srvp	73	27	as	as	IN
cord-006439-q7m4srvp	73	28	the	the	DT
cord-006439-q7m4srvp	73	29	prorenin	prorenin	JJ
cord-006439-q7m4srvp	73	30	receptor	receptor	NN
cord-006439-q7m4srvp	73	31	(	(	-LRB-
cord-006439-q7m4srvp	73	32	PRR	PRR	NNP
cord-006439-q7m4srvp	73	33	)	)	-RRB-
cord-006439-q7m4srvp	73	34	,	,	,
cord-006439-q7m4srvp	73	35	encoded	encode	VBN
cord-006439-q7m4srvp	73	36	by	by	IN
cord-006439-q7m4srvp	73	37	the	the	DT
cord-006439-q7m4srvp	73	38	ATP6ap2	ATP6ap2	NNP
cord-006439-q7m4srvp	73	39	gene	gene	NN
cord-006439-q7m4srvp	73	40	.	.	.
cord-006439-q7m4srvp	74	1	PRR	PRR	NNP
cord-006439-q7m4srvp	74	2	has	have	VBZ
cord-006439-q7m4srvp	74	3	the	the	DT
cord-006439-q7m4srvp	74	4	unique	unique	JJ
cord-006439-q7m4srvp	74	5	capability	capability	NN
cord-006439-q7m4srvp	74	6	to	to	TO
cord-006439-q7m4srvp	74	7	bind	bind	VB
cord-006439-q7m4srvp	74	8	prorenin	prorenin	NNS
cord-006439-q7m4srvp	74	9	and	and	CC
cord-006439-q7m4srvp	74	10	induce	induce	VB
cord-006439-q7m4srvp	74	11	its	-PRON-	PRP$
cord-006439-q7m4srvp	74	12	activation	activation	NN
cord-006439-q7m4srvp	74	13	without	without	IN
cord-006439-q7m4srvp	74	14	prosegment	prosegment	NN
cord-006439-q7m4srvp	74	15	removal	removal	NN
cord-006439-q7m4srvp	74	16	[	[	-LRB-
cord-006439-q7m4srvp	74	17	62	62	CD
cord-006439-q7m4srvp	74	18	]	]	-RRB-
cord-006439-q7m4srvp	74	19	.	.	.
cord-006439-q7m4srvp	75	1	PRR	PRR	NNP
cord-006439-q7m4srvp	75	2	is	be	VBZ
cord-006439-q7m4srvp	75	3	highly	highly	RB
cord-006439-q7m4srvp	75	4	expressed	express	VBN
cord-006439-q7m4srvp	75	5	in	in	IN
cord-006439-q7m4srvp	75	6	neurons	neuron	NNS
cord-006439-q7m4srvp	75	7	and	and	CC
cord-006439-q7m4srvp	75	8	some	some	DT
cord-006439-q7m4srvp	75	9	microglia	microglia	JJ
cord-006439-q7m4srvp	75	10	cells	cell	NNS
cord-006439-q7m4srvp	75	11	and	and	CC
cord-006439-q7m4srvp	75	12	has	have	VBZ
cord-006439-q7m4srvp	75	13	been	be	VBN
cord-006439-q7m4srvp	75	14	detected	detect	VBN
cord-006439-q7m4srvp	75	15	in	in	IN
cord-006439-q7m4srvp	75	16	several	several	JJ
cord-006439-q7m4srvp	75	17	brain	brain	NN
cord-006439-q7m4srvp	75	18	regions	region	NNS
cord-006439-q7m4srvp	75	19	implicated	implicate	VBN
cord-006439-q7m4srvp	75	20	in	in	IN
cord-006439-q7m4srvp	75	21	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	75	22	and	and	CC
cord-006439-q7m4srvp	75	23	autonomic	autonomic	JJ
cord-006439-q7m4srvp	75	24	control	control	NN
cord-006439-q7m4srvp	75	25	including	include	VBG
cord-006439-q7m4srvp	75	26	the	the	DT
cord-006439-q7m4srvp	75	27	subfornical	subfornical	JJ
cord-006439-q7m4srvp	75	28	organ	organ	NN
cord-006439-q7m4srvp	75	29	(	(	-LRB-
cord-006439-q7m4srvp	75	30	SFO	SFO	NNP
cord-006439-q7m4srvp	75	31	)	)	-RRB-
cord-006439-q7m4srvp	75	32	,	,	,
cord-006439-q7m4srvp	75	33	paraventricular	paraventricular	NNP
cord-006439-q7m4srvp	75	34	nucleus	nucleus	NN
cord-006439-q7m4srvp	75	35	(	(	-LRB-
cord-006439-q7m4srvp	75	36	PVN	PVN	NNP
cord-006439-q7m4srvp	75	37	)	)	-RRB-
cord-006439-q7m4srvp	75	38	,	,	,
cord-006439-q7m4srvp	75	39	nucleus	nucleus	NN
cord-006439-q7m4srvp	75	40	of	of	IN
cord-006439-q7m4srvp	75	41	the	the	DT
cord-006439-q7m4srvp	75	42	solitary	solitary	JJ
cord-006439-q7m4srvp	75	43	tract	tract	NN
cord-006439-q7m4srvp	75	44	(	(	-LRB-
cord-006439-q7m4srvp	75	45	NTS	NTS	NNP
cord-006439-q7m4srvp	75	46	)	)	-RRB-
cord-006439-q7m4srvp	75	47	,	,	,
cord-006439-q7m4srvp	75	48	and	and	CC
cord-006439-q7m4srvp	75	49	the	the	DT
cord-006439-q7m4srvp	75	50	rostral	rostral	JJ
cord-006439-q7m4srvp	75	51	ventrolateral	ventrolateral	JJ
cord-006439-q7m4srvp	75	52	medulla	medulla	NN
cord-006439-q7m4srvp	75	53	(	(	-LRB-
cord-006439-q7m4srvp	75	54	RVLM	RVLM	NNP
cord-006439-q7m4srvp	75	55	)	)	-RRB-
cord-006439-q7m4srvp	76	1	[	[	-LRB-
cord-006439-q7m4srvp	76	2	63•	63•	CD
cord-006439-q7m4srvp	76	3	,	,	,
cord-006439-q7m4srvp	76	4	64	64	CD
cord-006439-q7m4srvp	76	5	]	]	-RRB-
cord-006439-q7m4srvp	76	6	.	.	.
cord-006439-q7m4srvp	77	1	Despite	despite	IN
cord-006439-q7m4srvp	77	2	initial	initial	JJ
cord-006439-q7m4srvp	77	3	reports	report	NNS
cord-006439-q7m4srvp	77	4	indicating	indicate	VBG
cord-006439-q7m4srvp	77	5	that	that	IN
cord-006439-q7m4srvp	77	6	PRR	PRR	NNP
cord-006439-q7m4srvp	77	7	might	may	MD
cord-006439-q7m4srvp	77	8	be	be	VB
cord-006439-q7m4srvp	77	9	involved	involve	VBN
cord-006439-q7m4srvp	77	10	in	in	IN
cord-006439-q7m4srvp	77	11	hypertension	hypertension	NN
cord-006439-q7m4srvp	77	12	through	through	IN
cord-006439-q7m4srvp	77	13	local	local	JJ
cord-006439-q7m4srvp	77	14	generation	generation	NN
cord-006439-q7m4srvp	77	15	of	of	IN
cord-006439-q7m4srvp	77	16	ANG	ANG	NNP
cord-006439-q7m4srvp	77	17	-	-	HYPH
cord-006439-q7m4srvp	77	18	II	II	NNP
cord-006439-q7m4srvp	77	19	,	,	,
cord-006439-q7m4srvp	77	20	other	other	JJ
cord-006439-q7m4srvp	77	21	roles	role	NNS
cord-006439-q7m4srvp	77	22	that	that	WDT
cord-006439-q7m4srvp	77	23	are	be	VBP
cord-006439-q7m4srvp	77	24	independent	independent	JJ
cord-006439-q7m4srvp	77	25	of	of	IN
cord-006439-q7m4srvp	77	26	RAS	RAS	NNP
cord-006439-q7m4srvp	77	27	activation	activation	NN
cord-006439-q7m4srvp	77	28	have	have	VBP
cord-006439-q7m4srvp	77	29	been	be	VBN
cord-006439-q7m4srvp	77	30	described	describe	VBN
cord-006439-q7m4srvp	77	31	(	(	-LRB-
cord-006439-q7m4srvp	77	32	reviewed	review	VBN
cord-006439-q7m4srvp	77	33	in	in	IN
cord-006439-q7m4srvp	77	34	[	[	-LRB-
cord-006439-q7m4srvp	77	35	65	65	CD
cord-006439-q7m4srvp	77	36	]	]	-RRB-
cord-006439-q7m4srvp	77	37	)	)	-RRB-
cord-006439-q7m4srvp	77	38	.	.	.
cord-006439-q7m4srvp	78	1	For	for	IN
cord-006439-q7m4srvp	78	2	instance	instance	NN
cord-006439-q7m4srvp	78	3	,	,	,
cord-006439-q7m4srvp	78	4	the	the	DT
cord-006439-q7m4srvp	78	5	transmembrane	transmembrane	NN
cord-006439-q7m4srvp	78	6	domain	domain	NN
cord-006439-q7m4srvp	78	7	of	of	IN
cord-006439-q7m4srvp	78	8	the	the	DT
cord-006439-q7m4srvp	78	9	PRR	PRR	NNP
cord-006439-q7m4srvp	78	10	interacts	interact	VBZ
cord-006439-q7m4srvp	78	11	with	with	IN
cord-006439-q7m4srvp	78	12	the	the	DT
cord-006439-q7m4srvp	78	13	vacuolar	vacuolar	JJ
cord-006439-q7m4srvp	78	14	H(+)-ATPase	H(+)-ATPase	NNP
cord-006439-q7m4srvp	78	15	and	and	CC
cord-006439-q7m4srvp	78	16	plays	play	VBZ
cord-006439-q7m4srvp	78	17	an	an	DT
cord-006439-q7m4srvp	78	18	important	important	JJ
cord-006439-q7m4srvp	78	19	role	role	NN
cord-006439-q7m4srvp	78	20	in	in	IN
cord-006439-q7m4srvp	78	21	lysosomal	lysosomal	JJ
cord-006439-q7m4srvp	78	22	function	function	NN
cord-006439-q7m4srvp	78	23	and	and	CC
cord-006439-q7m4srvp	78	24	neuronal	neuronal	JJ
cord-006439-q7m4srvp	78	25	development	development	NN
cord-006439-q7m4srvp	78	26	[	[	-LRB-
cord-006439-q7m4srvp	78	27	66	66	CD
cord-006439-q7m4srvp	78	28	]	]	-RRB-
cord-006439-q7m4srvp	78	29	.	.	.
cord-006439-q7m4srvp	79	1	In	in	IN
cord-006439-q7m4srvp	79	2	humans	human	NNS
cord-006439-q7m4srvp	79	3	,	,	,
cord-006439-q7m4srvp	79	4	a	a	DT
cord-006439-q7m4srvp	79	5	unique	unique	JJ
cord-006439-q7m4srvp	79	6	mutation	mutation	NN
cord-006439-q7m4srvp	79	7	(	(	-LRB-
cord-006439-q7m4srvp	79	8	c.321C	c.321C	NNP
cord-006439-q7m4srvp	79	9	>	>	XX
cord-006439-q7m4srvp	79	10	T	T	NNP
cord-006439-q7m4srvp	79	11	,	,	,
cord-006439-q7m4srvp	79	12	p	p	NN
cord-006439-q7m4srvp	79	13	.	.	.
cord-006439-q7m4srvp	79	14	D107D	D107D	NNP
cord-006439-q7m4srvp	79	15	)	)	-RRB-
cord-006439-q7m4srvp	79	16	in	in	IN
cord-006439-q7m4srvp	79	17	the	the	DT
cord-006439-q7m4srvp	79	18	PRR	PRR	NNP
cord-006439-q7m4srvp	79	19	locus	locus	NN
cord-006439-q7m4srvp	79	20	is	be	VBZ
cord-006439-q7m4srvp	79	21	associated	associate	VBN
cord-006439-q7m4srvp	79	22	with	with	IN
cord-006439-q7m4srvp	79	23	X	x	NN
cord-006439-q7m4srvp	79	24	-	-	HYPH
cord-006439-q7m4srvp	79	25	linked	link	VBN
cord-006439-q7m4srvp	79	26	mental	mental	JJ
cord-006439-q7m4srvp	79	27	retardation	retardation	NN
cord-006439-q7m4srvp	79	28	and	and	CC
cord-006439-q7m4srvp	79	29	epilepsy	epilepsy	NN
cord-006439-q7m4srvp	79	30	[	[	-LRB-
cord-006439-q7m4srvp	79	31	67	67	CD
cord-006439-q7m4srvp	79	32	]	]	-RRB-
cord-006439-q7m4srvp	79	33	.	.	.
cord-006439-q7m4srvp	80	1	Although	although	IN
cord-006439-q7m4srvp	80	2	many	many	JJ
cord-006439-q7m4srvp	80	3	RAS	RAS	NNP
cord-006439-q7m4srvp	80	4	-	-	HYPH
cord-006439-q7m4srvp	80	5	independent	independent	JJ
cord-006439-q7m4srvp	80	6	functions	function	NNS
cord-006439-q7m4srvp	80	7	of	of	IN
cord-006439-q7m4srvp	80	8	PRR	PRR	NNP
cord-006439-q7m4srvp	80	9	are	be	VBP
cord-006439-q7m4srvp	80	10	well	well	RB
cord-006439-q7m4srvp	80	11	defined	define	VBN
cord-006439-q7m4srvp	80	12	in	in	IN
cord-006439-q7m4srvp	80	13	kidney	kidney	NN
cord-006439-q7m4srvp	80	14	,	,	,
cord-006439-q7m4srvp	80	15	the	the	DT
cord-006439-q7m4srvp	80	16	RAS	RAS	NNP
cord-006439-q7m4srvp	80	17	-	-	HYPH
cord-006439-q7m4srvp	80	18	independent	independent	JJ
cord-006439-q7m4srvp	80	19	functions	function	NNS
cord-006439-q7m4srvp	80	20	of	of	IN
cord-006439-q7m4srvp	80	21	PRR	PRR	NNP
cord-006439-q7m4srvp	80	22	in	in	IN
cord-006439-q7m4srvp	80	23	the	the	DT
cord-006439-q7m4srvp	80	24	brain	brain	NN
cord-006439-q7m4srvp	80	25	are	be	VBP
cord-006439-q7m4srvp	80	26	not	not	RB
cord-006439-q7m4srvp	80	27	completely	completely	RB
cord-006439-q7m4srvp	80	28	understood	understand	VBN
cord-006439-q7m4srvp	80	29	[	[	-LRB-
cord-006439-q7m4srvp	80	30	49	49	CD
cord-006439-q7m4srvp	80	31	,	,	,
cord-006439-q7m4srvp	80	32	66	66	CD
cord-006439-q7m4srvp	80	33	,	,	,
cord-006439-q7m4srvp	81	1	[	[	-LRB-
cord-006439-q7m4srvp	81	2	68	68	CD
cord-006439-q7m4srvp	81	3	]	]	-RRB-
cord-006439-q7m4srvp	81	4	[	[	-LRB-
cord-006439-q7m4srvp	81	5	69	69	CD
cord-006439-q7m4srvp	81	6	]	]	-RRB-
cord-006439-q7m4srvp	81	7	[	[	-LRB-
cord-006439-q7m4srvp	81	8	70	70	CD
cord-006439-q7m4srvp	81	9	]	]	-RRB-
cord-006439-q7m4srvp	81	10	.	.	.
cord-006439-q7m4srvp	82	1	In	in	IN
cord-006439-q7m4srvp	82	2	mice	mouse	NNS
cord-006439-q7m4srvp	82	3	where	where	WRB
cord-006439-q7m4srvp	82	4	neuronal	neuronal	JJ
cord-006439-q7m4srvp	82	5	PRR	PRR	NNP
cord-006439-q7m4srvp	82	6	was	be	VBD
cord-006439-q7m4srvp	82	7	ablated	ablate	VBN
cord-006439-q7m4srvp	82	8	at	at	IN
cord-006439-q7m4srvp	82	9	embryonic	embryonic	JJ
cord-006439-q7m4srvp	82	10	daỹ	daỹ	NNS
cord-006439-q7m4srvp	82	11	18.5	18.5	CD
cord-006439-q7m4srvp	82	12	(	(	-LRB-
cord-006439-q7m4srvp	82	13	neuron	neuron	NN
cord-006439-q7m4srvp	82	14	filament	filament	NN
cord-006439-q7m4srvp	82	15	promoter	promoter	NN
cord-006439-q7m4srvp	82	16	-	-	HYPH
cord-006439-q7m4srvp	82	17	CRE	CRE	NNP
cord-006439-q7m4srvp	82	18	crossed	cross	VBD
cord-006439-q7m4srvp	82	19	with	with	IN
cord-006439-q7m4srvp	82	20	PRRfloxed	prrfloxed	JJ
cord-006439-q7m4srvp	82	21	mice	mouse	NNS
cord-006439-q7m4srvp	82	22	;	;	:
cord-006439-q7m4srvp	82	23	Nefh	Nefh	NNP
cord-006439-q7m4srvp	82	24	-	-	HYPH
cord-006439-q7m4srvp	82	25	PRRKO	PRRKO	NNP
cord-006439-q7m4srvp	82	26	)	)	-RRB-
cord-006439-q7m4srvp	82	27	,	,	,
cord-006439-q7m4srvp	82	28	central	central	JJ
cord-006439-q7m4srvp	82	29	generation	generation	NN
cord-006439-q7m4srvp	82	30	of	of	IN
cord-006439-q7m4srvp	82	31	ANG	ANG	NNP
cord-006439-q7m4srvp	82	32	-	-	HYPH
cord-006439-q7m4srvp	82	33	II	II	NNP
cord-006439-q7m4srvp	82	34	in	in	IN
cord-006439-q7m4srvp	82	35	response	response	NN
cord-006439-q7m4srvp	82	36	to	to	IN
cord-006439-q7m4srvp	82	37	intracerebroventricular	intracerebroventricular	NNP
cord-006439-q7m4srvp	82	38	administration	administration	NN
cord-006439-q7m4srvp	82	39	of	of	IN
cord-006439-q7m4srvp	82	40	recombinant	recombinant	JJ
cord-006439-q7m4srvp	82	41	prorenin	prorenin	NNP
cord-006439-q7m4srvp	82	42	was	be	VBD
cord-006439-q7m4srvp	82	43	attenuated	attenuate	VBN
cord-006439-q7m4srvp	82	44	.	.	.
cord-006439-q7m4srvp	83	1	To	to	TO
cord-006439-q7m4srvp	83	2	study	study	VB
cord-006439-q7m4srvp	83	3	the	the	DT
cord-006439-q7m4srvp	83	4	role	role	NN
cord-006439-q7m4srvp	83	5	of	of	IN
cord-006439-q7m4srvp	83	6	neuronal	neuronal	JJ
cord-006439-q7m4srvp	83	7	PRR	PRR	NNP
cord-006439-q7m4srvp	83	8	in	in	IN
cord-006439-q7m4srvp	83	9	the	the	DT
cord-006439-q7m4srvp	83	10	pathogenesis	pathogenesis	NN
cord-006439-q7m4srvp	83	11	of	of	IN
cord-006439-q7m4srvp	83	12	hypertension	hypertension	NN
cord-006439-q7m4srvp	83	13	,	,	,
cord-006439-q7m4srvp	83	14	Feng	Feng	NNP
cord-006439-q7m4srvp	83	15	's	's	POS
cord-006439-q7m4srvp	83	16	lab	lab	NN
cord-006439-q7m4srvp	83	17	utilized	utilize	VBN
cord-006439-q7m4srvp	83	18	the	the	DT
cord-006439-q7m4srvp	83	19	model	model	NN
cord-006439-q7m4srvp	83	20	of	of	IN
cord-006439-q7m4srvp	83	21	low	low	JJ
cord-006439-q7m4srvp	83	22	-	-	HYPH
cord-006439-q7m4srvp	83	23	renin	renin	NN
cord-006439-q7m4srvp	83	24	hypertension	hypertension	NN
cord-006439-q7m4srvp	83	25	induced	induce	VBN
cord-006439-q7m4srvp	83	26	by	by	IN
cord-006439-q7m4srvp	83	27	deoxycorticosterone	deoxycorticosterone	NNP
cord-006439-q7m4srvp	83	28	acetate	acetate	NN
cord-006439-q7m4srvp	83	29	(	(	-LRB-
cord-006439-q7m4srvp	83	30	DOCA	DOCA	NNP
cord-006439-q7m4srvp	83	31	)	)	-RRB-
cord-006439-q7m4srvp	83	32	infusion	infusion	NN
cord-006439-q7m4srvp	83	33	and	and	CC
cord-006439-q7m4srvp	83	34	high	high	JJ
cord-006439-q7m4srvp	83	35	dietary	dietary	JJ
cord-006439-q7m4srvp	83	36	sodium	sodium	NN
cord-006439-q7m4srvp	83	37	.	.	.
cord-006439-q7m4srvp	84	1	Intracerebroventricular	intracerebroventricular	JJ
cord-006439-q7m4srvp	84	2	infusion	infusion	NN
cord-006439-q7m4srvp	84	3	of	of	IN
cord-006439-q7m4srvp	84	4	ACE	ACE	NNP
cord-006439-q7m4srvp	84	5	inhibitor	inhibitor	NN
cord-006439-q7m4srvp	84	6	prevents	prevent	VBZ
cord-006439-q7m4srvp	84	7	and	and	CC
cord-006439-q7m4srvp	84	8	reverses	reverse	VBZ
cord-006439-q7m4srvp	84	9	high	high	JJ
cord-006439-q7m4srvp	84	10	blood	blood	NN
cord-006439-q7m4srvp	84	11	pressure	pressure	NN
cord-006439-q7m4srvp	84	12	,	,	,
cord-006439-q7m4srvp	84	13	demonstrating	demonstrate	VBG
cord-006439-q7m4srvp	84	14	that	that	IN
cord-006439-q7m4srvp	84	15	production	production	NN
cord-006439-q7m4srvp	84	16	of	of	IN
cord-006439-q7m4srvp	84	17	ANG	ANG	NNP
cord-006439-q7m4srvp	84	18	-	-	HYPH
cord-006439-q7m4srvp	84	19	II	II	NNP
cord-006439-q7m4srvp	84	20	in	in	IN
cord-006439-q7m4srvp	84	21	the	the	DT
cord-006439-q7m4srvp	84	22	brain	brain	NN
cord-006439-q7m4srvp	84	23	is	be	VBZ
cord-006439-q7m4srvp	84	24	required	require	VBN
cord-006439-q7m4srvp	84	25	for	for	IN
cord-006439-q7m4srvp	84	26	DOCA	DOCA	NNP
cord-006439-q7m4srvp	84	27	-	-	HYPH
cord-006439-q7m4srvp	84	28	salt	salt	NN
cord-006439-q7m4srvp	84	29	hypertension	hypertension	NN
cord-006439-q7m4srvp	84	30	even	even	RB
cord-006439-q7m4srvp	84	31	though	though	IN
cord-006439-q7m4srvp	84	32	circulating	circulate	VBG
cord-006439-q7m4srvp	84	33	RAS	RAS	NNP
cord-006439-q7m4srvp	84	34	activity	activity	NN
cord-006439-q7m4srvp	84	35	is	be	VBZ
cord-006439-q7m4srvp	84	36	suppressed	suppress	VBN
cord-006439-q7m4srvp	84	37	[	[	-LRB-
cord-006439-q7m4srvp	84	38	71	71	CD
cord-006439-q7m4srvp	84	39	]	]	-RRB-
cord-006439-q7m4srvp	84	40	.	.	.
cord-006439-q7m4srvp	85	1	Moreover	moreover	RB
cord-006439-q7m4srvp	85	2	,	,	,
cord-006439-q7m4srvp	85	3	two	two	CD
cord-006439-q7m4srvp	85	4	separate	separate	JJ
cord-006439-q7m4srvp	85	5	studies	study	NNS
cord-006439-q7m4srvp	85	6	have	have	VBP
cord-006439-q7m4srvp	85	7	shown	show	VBN
cord-006439-q7m4srvp	85	8	that	that	IN
cord-006439-q7m4srvp	85	9	central	central	JJ
cord-006439-q7m4srvp	85	10	infusion	infusion	NN
cord-006439-q7m4srvp	85	11	of	of	IN
cord-006439-q7m4srvp	85	12	an	an	DT
cord-006439-q7m4srvp	85	13	AT	AT	NNP
cord-006439-q7m4srvp	85	14	1	1	CD
cord-006439-q7m4srvp	85	15	R	r	NN
cord-006439-q7m4srvp	85	16	blocker	blocker	NN
cord-006439-q7m4srvp	85	17	mimics	mimic	VBZ
cord-006439-q7m4srvp	85	18	the	the	DT
cord-006439-q7m4srvp	85	19	effects	effect	NNS
cord-006439-q7m4srvp	85	20	of	of	IN
cord-006439-q7m4srvp	85	21	central	central	JJ
cord-006439-q7m4srvp	85	22	delivery	delivery	NN
cord-006439-q7m4srvp	85	23	of	of	IN
cord-006439-q7m4srvp	85	24	ACE	ace	NN
cord-006439-q7m4srvp	85	25	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	85	26	[	[	-LRB-
cord-006439-q7m4srvp	85	27	72	72	CD
cord-006439-q7m4srvp	85	28	,	,	,
cord-006439-q7m4srvp	85	29	73	73	CD
cord-006439-q7m4srvp	85	30	]	]	-RRB-
cord-006439-q7m4srvp	85	31	.	.	.
cord-006439-q7m4srvp	86	1	Thus	thus	RB
cord-006439-q7m4srvp	86	2	,	,	,
cord-006439-q7m4srvp	86	3	it	-PRON-	PRP
cord-006439-q7m4srvp	86	4	is	be	VBZ
cord-006439-q7m4srvp	86	5	well	well	RB
cord-006439-q7m4srvp	86	6	accepted	accept	VBN
cord-006439-q7m4srvp	86	7	that	that	IN
cord-006439-q7m4srvp	86	8	the	the	DT
cord-006439-q7m4srvp	86	9	blood	blood	NN
cord-006439-q7m4srvp	86	10	pressure	pressure	NN
cord-006439-q7m4srvp	86	11	elevation	elevation	NN
cord-006439-q7m4srvp	86	12	in	in	IN
cord-006439-q7m4srvp	86	13	DOCA	DOCA	NNP
cord-006439-q7m4srvp	86	14	-	-	HYPH
cord-006439-q7m4srvp	86	15	salt	salt	NN
cord-006439-q7m4srvp	86	16	hypertension	hypertension	NN
cord-006439-q7m4srvp	86	17	is	be	VBZ
cord-006439-q7m4srvp	86	18	strongly	strongly	RB
cord-006439-q7m4srvp	86	19	driven	drive	VBN
cord-006439-q7m4srvp	86	20	by	by	IN
cord-006439-q7m4srvp	86	21	a	a	DT
cord-006439-q7m4srvp	86	22	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	86	23	mechanism	mechanism	NN
cord-006439-q7m4srvp	86	24	involving	involve	VBG
cord-006439-q7m4srvp	86	25	activation	activation	NN
cord-006439-q7m4srvp	86	26	of	of	IN
cord-006439-q7m4srvp	86	27	the	the	DT
cord-006439-q7m4srvp	86	28	brain	brain	NN
cord-006439-q7m4srvp	86	29	RAS	RAS	NNP
cord-006439-q7m4srvp	86	30	[	[	-LRB-
cord-006439-q7m4srvp	86	31	74	74	CD
cord-006439-q7m4srvp	86	32	]	]	-RRB-
cord-006439-q7m4srvp	86	33	.	.	.
cord-006439-q7m4srvp	87	1	Li	Li	NNP
cord-006439-q7m4srvp	87	2	et	et	NNP
cord-006439-q7m4srvp	87	3	al	al	NNP
cord-006439-q7m4srvp	87	4	.	.	NNP
cord-006439-q7m4srvp	87	5	reported	report	VBD
cord-006439-q7m4srvp	87	6	that	that	IN
cord-006439-q7m4srvp	87	7	the	the	DT
cord-006439-q7m4srvp	87	8	selective	selective	JJ
cord-006439-q7m4srvp	87	9	ablation	ablation	NN
cord-006439-q7m4srvp	87	10	of	of	IN
cord-006439-q7m4srvp	87	11	PRR	PRR	NNP
cord-006439-q7m4srvp	87	12	in	in	IN
cord-006439-q7m4srvp	87	13	neurons	neuron	NNS
cord-006439-q7m4srvp	87	14	attenuated	attenuate	VBD
cord-006439-q7m4srvp	87	15	the	the	DT
cord-006439-q7m4srvp	87	16	elevation	elevation	NN
cord-006439-q7m4srvp	87	17	of	of	IN
cord-006439-q7m4srvp	87	18	blood	blood	NN
cord-006439-q7m4srvp	87	19	pressure	pressure	NN
cord-006439-q7m4srvp	87	20	in	in	IN
cord-006439-q7m4srvp	87	21	DOCA	DOCA	NNP
cord-006439-q7m4srvp	87	22	-	-	HYPH
cord-006439-q7m4srvp	87	23	salt	salt	NN
cord-006439-q7m4srvp	87	24	hypertension	hypertension	NN
cord-006439-q7m4srvp	87	25	when	when	WRB
cord-006439-q7m4srvp	87	26	0.9	0.9	CD
cord-006439-q7m4srvp	87	27	M	M	NNP
cord-006439-q7m4srvp	87	28	NaCl	nacl	NN
cord-006439-q7m4srvp	87	29	was	be	VBD
cord-006439-q7m4srvp	87	30	the	the	DT
cord-006439-q7m4srvp	87	31	only	only	JJ
cord-006439-q7m4srvp	87	32	fluid	fluid	NN
cord-006439-q7m4srvp	87	33	offered	offer	VBD
cord-006439-q7m4srvp	87	34	[	[	-LRB-
cord-006439-q7m4srvp	87	35	75	75	CD
cord-006439-q7m4srvp	87	36	]	]	-RRB-
cord-006439-q7m4srvp	87	37	.	.	.
cord-006439-q7m4srvp	88	1	In	in	IN
cord-006439-q7m4srvp	88	2	contrast	contrast	NN
cord-006439-q7m4srvp	88	3	,	,	,
cord-006439-q7m4srvp	88	4	experiments	experiment	NNS
cord-006439-q7m4srvp	88	5	where	where	WRB
cord-006439-q7m4srvp	88	6	DOCA	DOCA	NNP
cord-006439-q7m4srvp	88	7	-	-	HYPH
cord-006439-q7m4srvp	88	8	treated	treat	VBN
cord-006439-q7m4srvp	88	9	Nefh	Nefh	NNP
cord-006439-q7m4srvp	88	10	-	-	HYPH
cord-006439-q7m4srvp	88	11	PRRKO	PRRKO	NNP
cord-006439-q7m4srvp	88	12	mice	mouse	NNS
cord-006439-q7m4srvp	88	13	were	be	VBD
cord-006439-q7m4srvp	88	14	exposed	expose	VBN
cord-006439-q7m4srvp	88	15	to	to	IN
cord-006439-q7m4srvp	88	16	two	two	CD
cord-006439-q7m4srvp	88	17	-	-	HYPH
cord-006439-q7m4srvp	88	18	bottle	bottle	NN
cord-006439-q7m4srvp	88	19	choice	choice	NN
cord-006439-q7m4srvp	88	20	paradigm	paradigm	NN
cord-006439-q7m4srvp	88	21	for	for	IN
cord-006439-q7m4srvp	88	22	the	the	DT
cord-006439-q7m4srvp	88	23	assessment	assessment	NN
cord-006439-q7m4srvp	88	24	of	of	IN
cord-006439-q7m4srvp	88	25	sodium	sodium	NN
cord-006439-q7m4srvp	88	26	preference	preference	NN
cord-006439-q7m4srvp	88	27	revealed	reveal	VBD
cord-006439-q7m4srvp	88	28	that	that	IN
cord-006439-q7m4srvp	88	29	the	the	DT
cord-006439-q7m4srvp	88	30	ablation	ablation	NN
cord-006439-q7m4srvp	88	31	of	of	IN
cord-006439-q7m4srvp	88	32	PRR	PRR	NNP
cord-006439-q7m4srvp	88	33	in	in	IN
cord-006439-q7m4srvp	88	34	neurons	neuron	NNS
cord-006439-q7m4srvp	88	35	is	be	VBZ
cord-006439-q7m4srvp	88	36	insufficient	insufficient	JJ
cord-006439-q7m4srvp	88	37	to	to	TO
cord-006439-q7m4srvp	88	38	decrease	decrease	VB
cord-006439-q7m4srvp	88	39	blood	blood	NN
cord-006439-q7m4srvp	88	40	pressure	pressure	NN
cord-006439-q7m4srvp	88	41	but	but	CC
cord-006439-q7m4srvp	88	42	suppressed	suppress	VBD
cord-006439-q7m4srvp	88	43	DOCA	DOCA	NNP
cord-006439-q7m4srvp	88	44	-	-	HYPH
cord-006439-q7m4srvp	88	45	induced	induce	VBN
cord-006439-q7m4srvp	88	46	saline	saline	NN
cord-006439-q7m4srvp	88	47	intake	intake	NN
cord-006439-q7m4srvp	88	48	[	[	-LRB-
cord-006439-q7m4srvp	88	49	76	76	CD
cord-006439-q7m4srvp	88	50	]	]	-RRB-
cord-006439-q7m4srvp	88	51	.	.	.
cord-006439-q7m4srvp	89	1	These	these	DT
cord-006439-q7m4srvp	89	2	data	datum	NNS
cord-006439-q7m4srvp	89	3	suggest	suggest	VBP
cord-006439-q7m4srvp	89	4	expression	expression	NN
cord-006439-q7m4srvp	89	5	of	of	IN
cord-006439-q7m4srvp	89	6	PRR	PRR	NNP
cord-006439-q7m4srvp	89	7	in	in	IN
cord-006439-q7m4srvp	89	8	specific	specific	JJ
cord-006439-q7m4srvp	89	9	brain	brain	NN
cord-006439-q7m4srvp	89	10	regions	region	NNS
cord-006439-q7m4srvp	89	11	controlling	control	VBG
cord-006439-q7m4srvp	89	12	drinking	drinking	NN
cord-006439-q7m4srvp	89	13	behavior	behavior	NN
cord-006439-q7m4srvp	89	14	,	,	,
cord-006439-q7m4srvp	89	15	such	such	JJ
cord-006439-q7m4srvp	89	16	as	as	IN
cord-006439-q7m4srvp	89	17	the	the	DT
cord-006439-q7m4srvp	89	18	SFO	SFO	NNP
cord-006439-q7m4srvp	89	19	is	be	VBZ
cord-006439-q7m4srvp	89	20	of	of	IN
cord-006439-q7m4srvp	89	21	physiological	physiological	JJ
cord-006439-q7m4srvp	89	22	relevance	relevance	NN
cord-006439-q7m4srvp	89	23	.	.	.
cord-006439-q7m4srvp	90	1	Recently	recently	RB
cord-006439-q7m4srvp	90	2	,	,	,
cord-006439-q7m4srvp	90	3	Souza	Souza	NNP
cord-006439-q7m4srvp	90	4	and	and	CC
cord-006439-q7m4srvp	90	5	colleagues	colleague	NNS
cord-006439-q7m4srvp	90	6	examined	examine	VBD
cord-006439-q7m4srvp	90	7	the	the	DT
cord-006439-q7m4srvp	90	8	role	role	NN
cord-006439-q7m4srvp	90	9	of	of	IN
cord-006439-q7m4srvp	90	10	PRR	PRR	NNP
cord-006439-q7m4srvp	90	11	in	in	IN
cord-006439-q7m4srvp	90	12	the	the	DT
cord-006439-q7m4srvp	90	13	PVN	PVN	NNP
cord-006439-q7m4srvp	90	14	,	,	,
cord-006439-q7m4srvp	90	15	a	a	DT
cord-006439-q7m4srvp	90	16	key	key	JJ
cord-006439-q7m4srvp	90	17	integratory	integratory	JJ
cord-006439-q7m4srvp	90	18	nucleus	nucleus	NN
cord-006439-q7m4srvp	90	19	involved	involve	VBN
cord-006439-q7m4srvp	90	20	in	in	IN
cord-006439-q7m4srvp	90	21	blood	blood	NN
cord-006439-q7m4srvp	90	22	pressure	pressure	NN
cord-006439-q7m4srvp	90	23	control	control	NN
cord-006439-q7m4srvp	90	24	[	[	-LRB-
cord-006439-q7m4srvp	90	25	77	77	CD
cord-006439-q7m4srvp	90	26	]	]	-RRB-
cord-006439-q7m4srvp	90	27	.	.	.
cord-006439-q7m4srvp	91	1	In	in	IN
cord-006439-q7m4srvp	91	2	this	this	DT
cord-006439-q7m4srvp	91	3	study	study	NN
cord-006439-q7m4srvp	91	4	,	,	,
cord-006439-q7m4srvp	91	5	PVNtargeted	pvntargeted	JJ
cord-006439-q7m4srvp	91	6	ablation	ablation	NN
cord-006439-q7m4srvp	91	7	of	of	IN
cord-006439-q7m4srvp	91	8	PRR	PRR	NNP
cord-006439-q7m4srvp	91	9	was	be	VBD
cord-006439-q7m4srvp	91	10	induced	induce	VBN
cord-006439-q7m4srvp	91	11	in	in	IN
cord-006439-q7m4srvp	91	12	PRR	PRR	NNP
cord-006439-q7m4srvp	91	13	-	-	HYPH
cord-006439-q7m4srvp	91	14	floxed	floxe	VBN
cord-006439-q7m4srvp	91	15	mice	mouse	NNS
cord-006439-q7m4srvp	91	16	by	by	IN
cord-006439-q7m4srvp	91	17	bilateral	bilateral	JJ
cord-006439-q7m4srvp	91	18	stereotactic	stereotactic	JJ
cord-006439-q7m4srvp	91	19	microinjection	microinjection	NN
cord-006439-q7m4srvp	91	20	of	of	IN
cord-006439-q7m4srvp	91	21	adeno	adeno	NN
cord-006439-q7m4srvp	91	22	-	-	HYPH
cord-006439-q7m4srvp	91	23	associated	associate	VBN
cord-006439-q7m4srvp	91	24	virus	virus	NN
cord-006439-q7m4srvp	91	25	(	(	-LRB-
cord-006439-q7m4srvp	91	26	AAV)-CRE	aav)-cre	NN
cord-006439-q7m4srvp	91	27	-	-	HYPH
cord-006439-q7m4srvp	91	28	GFP	gfp	NN
cord-006439-q7m4srvp	91	29	.	.	.
cord-006439-q7m4srvp	92	1	The	the	DT
cord-006439-q7m4srvp	92	2	reduction	reduction	NN
cord-006439-q7m4srvp	92	3	of	of	IN
cord-006439-q7m4srvp	92	4	PRR	PRR	NNP
cord-006439-q7m4srvp	92	5	expression	expression	NN
cord-006439-q7m4srvp	92	6	in	in	IN
cord-006439-q7m4srvp	92	7	the	the	DT
cord-006439-q7m4srvp	92	8	PVN	PVN	NNP
cord-006439-q7m4srvp	92	9	by	by	IN
cord-006439-q7m4srvp	92	10	less	less	JJR
cord-006439-q7m4srvp	92	11	than	than	IN
cord-006439-q7m4srvp	92	12	50	50	CD
cord-006439-q7m4srvp	92	13	%	%	NN
cord-006439-q7m4srvp	92	14	was	be	VBD
cord-006439-q7m4srvp	92	15	sufficient	sufficient	JJ
cord-006439-q7m4srvp	92	16	to	to	TO
cord-006439-q7m4srvp	92	17	attenuate	attenuate	VB
cord-006439-q7m4srvp	92	18	DOCA	DOCA	NNP
cord-006439-q7m4srvp	92	19	-	-	HYPH
cord-006439-q7m4srvp	92	20	salt	salt	NN
cord-006439-q7m4srvp	92	21	induced	induce	VBN
cord-006439-q7m4srvp	92	22	blood	blood	NN
cord-006439-q7m4srvp	92	23	pressure	pressure	NN
cord-006439-q7m4srvp	92	24	elevations	elevation	NNS
cord-006439-q7m4srvp	92	25	,	,	,
cord-006439-q7m4srvp	92	26	cardiac	cardiac	NN
cord-006439-q7m4srvp	92	27	and	and	CC
cord-006439-q7m4srvp	92	28	vasomotor	vasomotor	NN
cord-006439-q7m4srvp	92	29	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	92	30	over	over	IN
cord-006439-q7m4srvp	92	31	-	-	HYPH
cord-006439-q7m4srvp	92	32	activity	activity	NN
cord-006439-q7m4srvp	92	33	,	,	,
cord-006439-q7m4srvp	92	34	and	and	CC
cord-006439-q7m4srvp	92	35	improved	improved	JJ
cord-006439-q7m4srvp	92	36	cardiac	cardiac	JJ
cord-006439-q7m4srvp	92	37	parasympathetic	parasympathetic	JJ
cord-006439-q7m4srvp	92	38	function	function	NN
cord-006439-q7m4srvp	92	39	[	[	-LRB-
cord-006439-q7m4srvp	92	40	63•	63•	NNP
cord-006439-q7m4srvp	92	41	]	]	-RRB-
cord-006439-q7m4srvp	92	42	.	.	.
cord-006439-q7m4srvp	93	1	In	in	IN
cord-006439-q7m4srvp	93	2	addition	addition	NN
cord-006439-q7m4srvp	93	3	,	,	,
cord-006439-q7m4srvp	93	4	live	live	JJ
cord-006439-q7m4srvp	93	5	-	-	HYPH
cord-006439-q7m4srvp	93	6	cell	cell	NN
cord-006439-q7m4srvp	93	7	calcium	calcium	NN
cord-006439-q7m4srvp	93	8	recordings	recording	NNS
cord-006439-q7m4srvp	93	9	utilizing	utilize	VBG
cord-006439-q7m4srvp	93	10	a	a	DT
cord-006439-q7m4srvp	93	11	novel	novel	JJ
cord-006439-q7m4srvp	93	12	calcium	calcium	NN
cord-006439-q7m4srvp	93	13	biosensor	biosensor	NN
cord-006439-q7m4srvp	93	14	(	(	-LRB-
cord-006439-q7m4srvp	93	15	GCaMP6	GCaMP6	NNP
cord-006439-q7m4srvp	93	16	)	)	-RRB-
cord-006439-q7m4srvp	93	17	revealed	reveal	VBD
cord-006439-q7m4srvp	93	18	PVNtargeted	pvntargeted	JJ
cord-006439-q7m4srvp	93	19	ablation	ablation	NN
cord-006439-q7m4srvp	93	20	of	of	IN
cord-006439-q7m4srvp	93	21	PRR	PRR	NNP
cord-006439-q7m4srvp	93	22	attenuates	attenuate	VBZ
cord-006439-q7m4srvp	93	23	calcium	calcium	NN
cord-006439-q7m4srvp	93	24	influx	influx	NN
cord-006439-q7m4srvp	93	25	in	in	IN
cord-006439-q7m4srvp	93	26	response	response	NN
cord-006439-q7m4srvp	93	27	to	to	IN
cord-006439-q7m4srvp	93	28	ANG	ANG	NNP
cord-006439-q7m4srvp	93	29	-	-	HYPH
cord-006439-q7m4srvp	93	30	II	II	NNP
cord-006439-q7m4srvp	93	31	in	in	IN
cord-006439-q7m4srvp	93	32	DOCA	DOCA	NNP
cord-006439-q7m4srvp	93	33	-	-	HYPH
cord-006439-q7m4srvp	93	34	salt	salt	NN
cord-006439-q7m4srvp	93	35	hypertension	hypertension	NN
cord-006439-q7m4srvp	93	36	.	.	.
cord-006439-q7m4srvp	94	1	Despite	despite	IN
cord-006439-q7m4srvp	94	2	the	the	DT
cord-006439-q7m4srvp	94	3	growing	grow	VBG
cord-006439-q7m4srvp	94	4	evidence	evidence	NN
cord-006439-q7m4srvp	94	5	indicating	indicate	VBG
cord-006439-q7m4srvp	94	6	the	the	DT
cord-006439-q7m4srvp	94	7	importance	importance	NN
cord-006439-q7m4srvp	94	8	of	of	IN
cord-006439-q7m4srvp	94	9	PRR	PRR	NNP
cord-006439-q7m4srvp	94	10	in	in	IN
cord-006439-q7m4srvp	94	11	the	the	DT
cord-006439-q7m4srvp	94	12	CNS	CNS	NNP
cord-006439-q7m4srvp	94	13	to	to	TO
cord-006439-q7m4srvp	94	14	control	control	VB
cord-006439-q7m4srvp	94	15	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	94	16	function	function	NN
cord-006439-q7m4srvp	94	17	,	,	,
cord-006439-q7m4srvp	94	18	there	there	EX
cord-006439-q7m4srvp	94	19	is	be	VBZ
cord-006439-q7m4srvp	94	20	no	no	DT
cord-006439-q7m4srvp	94	21	generalized	generalized	JJ
cord-006439-q7m4srvp	94	22	consensus	consensus	NN
cord-006439-q7m4srvp	94	23	whether	whether	IN
cord-006439-q7m4srvp	94	24	the	the	DT
cord-006439-q7m4srvp	94	25	underlying	underlie	VBG
cord-006439-q7m4srvp	94	26	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	94	27	require	require	VBP
cord-006439-q7m4srvp	94	28	local	local	JJ
cord-006439-q7m4srvp	94	29	ANG	ANG	NNP
cord-006439-q7m4srvp	94	30	-	-	HYPH
cord-006439-q7m4srvp	94	31	II	II	NNP
cord-006439-q7m4srvp	94	32	generation	generation	NN
cord-006439-q7m4srvp	94	33	.	.	.
cord-006439-q7m4srvp	95	1	It	-PRON-	PRP
cord-006439-q7m4srvp	95	2	is	be	VBZ
cord-006439-q7m4srvp	95	3	likely	likely	JJ
cord-006439-q7m4srvp	95	4	that	that	IN
cord-006439-q7m4srvp	95	5	both	both	CC
cord-006439-q7m4srvp	95	6	ANG	ANG	NNP
cord-006439-q7m4srvp	95	7	-	-	HYPH
cord-006439-q7m4srvp	95	8	II	II	NNP
cord-006439-q7m4srvp	95	9	-	-	HYPH
cord-006439-q7m4srvp	95	10	dependent	dependent	JJ
cord-006439-q7m4srvp	95	11	and	and	CC
cord-006439-q7m4srvp	95	12	ANG	ANG	NNP
cord-006439-q7m4srvp	95	13	-	-	HYPH
cord-006439-q7m4srvp	95	14	II	II	NNP
cord-006439-q7m4srvp	95	15	-	-	HYPH
cord-006439-q7m4srvp	95	16	independent	independent	JJ
cord-006439-q7m4srvp	95	17	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	95	18	might	may	MD
cord-006439-q7m4srvp	95	19	occur	occur	VB
cord-006439-q7m4srvp	95	20	simultaneously	simultaneously	RB
cord-006439-q7m4srvp	95	21	at	at	IN
cord-006439-q7m4srvp	95	22	different	different	JJ
cord-006439-q7m4srvp	95	23	degrees	degree	NNS
cord-006439-q7m4srvp	95	24	depending	depend	VBG
cord-006439-q7m4srvp	95	25	on	on	IN
cord-006439-q7m4srvp	95	26	the	the	DT
cord-006439-q7m4srvp	95	27	neuroanatomical	neuroanatomical	JJ
cord-006439-q7m4srvp	95	28	localization	localization	NN
cord-006439-q7m4srvp	95	29	and	and	CC
cord-006439-q7m4srvp	95	30	cell	cell	NN
cord-006439-q7m4srvp	95	31	types	type	NNS
cord-006439-q7m4srvp	95	32	,	,	,
cord-006439-q7m4srvp	95	33	as	as	RB
cord-006439-q7m4srvp	95	34	well	well	RB
cord-006439-q7m4srvp	95	35	as	as	IN
cord-006439-q7m4srvp	95	36	different	different	JJ
cord-006439-q7m4srvp	95	37	physiological	physiological	JJ
cord-006439-q7m4srvp	95	38	and	and	CC
cord-006439-q7m4srvp	95	39	pathological	pathological	JJ
cord-006439-q7m4srvp	95	40	circumstances	circumstance	NNS
cord-006439-q7m4srvp	95	41	[	[	-LRB-
cord-006439-q7m4srvp	95	42	78	78	CD
cord-006439-q7m4srvp	95	43	]	]	-RRB-
cord-006439-q7m4srvp	95	44	.	.	.
cord-006439-q7m4srvp	96	1	There	there	EX
cord-006439-q7m4srvp	96	2	is	be	VBZ
cord-006439-q7m4srvp	96	3	a	a	DT
cord-006439-q7m4srvp	96	4	growing	grow	VBG
cord-006439-q7m4srvp	96	5	interest	interest	NN
cord-006439-q7m4srvp	96	6	in	in	IN
cord-006439-q7m4srvp	96	7	the	the	DT
cord-006439-q7m4srvp	96	8	soluble	soluble	JJ
cord-006439-q7m4srvp	96	9	PRR	PRR	NNP
cord-006439-q7m4srvp	96	10	fragment	fragment	NN
cord-006439-q7m4srvp	96	11	(	(	-LRB-
cord-006439-q7m4srvp	96	12	sPRR	sprr	JJ
cord-006439-q7m4srvp	96	13	)	)	-RRB-
cord-006439-q7m4srvp	96	14	which	which	WDT
cord-006439-q7m4srvp	96	15	arises	arise	VBZ
cord-006439-q7m4srvp	96	16	from	from	IN
cord-006439-q7m4srvp	96	17	the	the	DT
cord-006439-q7m4srvp	96	18	proteolytic	proteolytic	JJ
cord-006439-q7m4srvp	96	19	cleavage	cleavage	NN
cord-006439-q7m4srvp	96	20	of	of	IN
cord-006439-q7m4srvp	96	21	PRR	PRR	NNP
cord-006439-q7m4srvp	96	22	by	by	IN
cord-006439-q7m4srvp	96	23	furin	furin	NN
cord-006439-q7m4srvp	96	24	or	or	CC
cord-006439-q7m4srvp	96	25	site-1	site-1	NNP
cord-006439-q7m4srvp	96	26	protease	protease	NN
cord-006439-q7m4srvp	96	27	to	to	TO
cord-006439-q7m4srvp	96	28	generate	generate	VB
cord-006439-q7m4srvp	96	29	a	a	DT
cord-006439-q7m4srvp	96	30	10-kD	10-kd	CD
cord-006439-q7m4srvp	96	31	transmembrane/	transmembrane/	CD
cord-006439-q7m4srvp	96	32	cytoplasmic	cytoplasmic	JJ
cord-006439-q7m4srvp	96	33	fragment	fragment	NN
cord-006439-q7m4srvp	96	34	and	and	CC
cord-006439-q7m4srvp	96	35	a	a	DT
cord-006439-q7m4srvp	96	36	28-kD	28-kd	CD
cord-006439-q7m4srvp	96	37	soluble	soluble	JJ
cord-006439-q7m4srvp	96	38	PRR	PRR	NNP
cord-006439-q7m4srvp	96	39	form	form	NN
cord-006439-q7m4srvp	96	40	[	[	-LRB-
cord-006439-q7m4srvp	96	41	79	79	CD
cord-006439-q7m4srvp	96	42	,	,	,
cord-006439-q7m4srvp	96	43	80	80	CD
cord-006439-q7m4srvp	96	44	]	]	-RRB-
cord-006439-q7m4srvp	96	45	.	.	.
cord-006439-q7m4srvp	97	1	Growing	grow	VBG
cord-006439-q7m4srvp	97	2	evidence	evidence	NN
cord-006439-q7m4srvp	97	3	supports	support	VBZ
cord-006439-q7m4srvp	97	4	that	that	IN
cord-006439-q7m4srvp	97	5	elevation	elevation	NN
cord-006439-q7m4srvp	97	6	of	of	IN
cord-006439-q7m4srvp	97	7	circulating	circulate	VBG
cord-006439-q7m4srvp	97	8	sPRR	sprr	JJ
cord-006439-q7m4srvp	97	9	levels	level	NNS
cord-006439-q7m4srvp	97	10	are	be	VBP
cord-006439-q7m4srvp	97	11	associated	associate	VBN
cord-006439-q7m4srvp	97	12	with	with	IN
cord-006439-q7m4srvp	97	13	high	high	JJ
cord-006439-q7m4srvp	97	14	blood	blood	NN
cord-006439-q7m4srvp	97	15	pressure	pressure	NN
cord-006439-q7m4srvp	97	16	,	,	,
cord-006439-q7m4srvp	97	17	chronic	chronic	JJ
cord-006439-q7m4srvp	97	18	kidney	kidney	NN
cord-006439-q7m4srvp	97	19	disease	disease	NN
cord-006439-q7m4srvp	97	20	,	,	,
cord-006439-q7m4srvp	97	21	preeclampsia	preeclampsia	NN
cord-006439-q7m4srvp	97	22	,	,	,
cord-006439-q7m4srvp	97	23	and	and	CC
cord-006439-q7m4srvp	97	24	obstructive	obstructive	JJ
cord-006439-q7m4srvp	97	25	sleep	sleep	NN
cord-006439-q7m4srvp	97	26	apnea	apnea	NN
cord-006439-q7m4srvp	97	27	[	[	-LRB-
cord-006439-q7m4srvp	97	28	81	81	CD
cord-006439-q7m4srvp	97	29	]	]	-RRB-
cord-006439-q7m4srvp	97	30	[	[	-LRB-
cord-006439-q7m4srvp	97	31	82	82	CD
cord-006439-q7m4srvp	97	32	]	]	-RRB-
cord-006439-q7m4srvp	98	1	[	[	-LRB-
cord-006439-q7m4srvp	98	2	83	83	CD
cord-006439-q7m4srvp	98	3	]	]	-RRB-
cord-006439-q7m4srvp	98	4	[	[	-LRB-
cord-006439-q7m4srvp	98	5	84	84	CD
cord-006439-q7m4srvp	98	6	]	]	-RRB-
cord-006439-q7m4srvp	98	7	.	.	.
cord-006439-q7m4srvp	99	1	However	however	RB
cord-006439-q7m4srvp	99	2	,	,	,
cord-006439-q7m4srvp	99	3	the	the	DT
cord-006439-q7m4srvp	99	4	biological	biological	JJ
cord-006439-q7m4srvp	99	5	function	function	NN
cord-006439-q7m4srvp	99	6	and	and	CC
cord-006439-q7m4srvp	99	7	the	the	DT
cord-006439-q7m4srvp	99	8	physiological	physiological	JJ
cord-006439-q7m4srvp	99	9	relevance	relevance	NN
cord-006439-q7m4srvp	99	10	of	of	IN
cord-006439-q7m4srvp	99	11	sPRR	sprr	NN
cord-006439-q7m4srvp	99	12	were	be	VBD
cord-006439-q7m4srvp	99	13	completely	completely	RB
cord-006439-q7m4srvp	99	14	unknown	unknown	JJ
cord-006439-q7m4srvp	99	15	until	until	IN
cord-006439-q7m4srvp	99	16	recently	recently	RB
cord-006439-q7m4srvp	99	17	.	.	.
cord-006439-q7m4srvp	100	1	Many	many	JJ
cord-006439-q7m4srvp	100	2	functions	function	NNS
cord-006439-q7m4srvp	100	3	of	of	IN
cord-006439-q7m4srvp	100	4	sPRR	sprr	JJ
cord-006439-q7m4srvp	100	5	controlling	control	VBG
cord-006439-q7m4srvp	100	6	renal	renal	JJ
cord-006439-q7m4srvp	100	7	function	function	NN
cord-006439-q7m4srvp	100	8	have	have	VBP
cord-006439-q7m4srvp	100	9	been	be	VBN
cord-006439-q7m4srvp	100	10	reported	report	VBN
cord-006439-q7m4srvp	100	11	.	.	.
cord-006439-q7m4srvp	101	1	For	for	IN
cord-006439-q7m4srvp	101	2	instance	instance	NN
cord-006439-q7m4srvp	101	3	,	,	,
cord-006439-q7m4srvp	101	4	sPRR	sPRR	NNP
cord-006439-q7m4srvp	101	5	exerts	exert	VBZ
cord-006439-q7m4srvp	101	6	antidiuretic	antidiuretic	JJ
cord-006439-q7m4srvp	101	7	actions	action	NNS
cord-006439-q7m4srvp	101	8	in	in	IN
cord-006439-q7m4srvp	101	9	part	part	NN
cord-006439-q7m4srvp	101	10	by	by	IN
cord-006439-q7m4srvp	101	11	inducing	induce	VBG
cord-006439-q7m4srvp	101	12	frizzled	frizzle	VBN
cord-006439-q7m4srvp	101	13	8-dependent	8-dependent	CD
cord-006439-q7m4srvp	101	14	stimulation	stimulation	NN
cord-006439-q7m4srvp	101	15	of	of	IN
cord-006439-q7m4srvp	101	16	aquaporin	aquaporin	NNP
cord-006439-q7m4srvp	101	17	2	2	CD
cord-006439-q7m4srvp	101	18	expression	expression	NN
cord-006439-q7m4srvp	101	19	in	in	IN
cord-006439-q7m4srvp	101	20	the	the	DT
cord-006439-q7m4srvp	101	21	collecting	collecting	NN
cord-006439-q7m4srvp	101	22	duct	duct	NN
cord-006439-q7m4srvp	101	23	[	[	-LRB-
cord-006439-q7m4srvp	101	24	49	49	CD
cord-006439-q7m4srvp	101	25	]	]	-RRB-
cord-006439-q7m4srvp	101	26	.	.	.
cord-006439-q7m4srvp	102	1	Studies	study	NNS
cord-006439-q7m4srvp	102	2	specifically	specifically	RB
cord-006439-q7m4srvp	102	3	aiming	aim	VBG
cord-006439-q7m4srvp	102	4	to	to	TO
cord-006439-q7m4srvp	102	5	elucidate	elucidate	VB
cord-006439-q7m4srvp	102	6	the	the	DT
cord-006439-q7m4srvp	102	7	role	role	NN
cord-006439-q7m4srvp	102	8	of	of	IN
cord-006439-q7m4srvp	102	9	sPRR	sprr	NN
cord-006439-q7m4srvp	102	10	in	in	IN
cord-006439-q7m4srvp	102	11	the	the	DT
cord-006439-q7m4srvp	102	12	CNS	CNS	NNP
cord-006439-q7m4srvp	102	13	have	have	VBP
cord-006439-q7m4srvp	102	14	not	not	RB
cord-006439-q7m4srvp	102	15	been	be	VBN
cord-006439-q7m4srvp	102	16	reported	report	VBN
cord-006439-q7m4srvp	102	17	.	.	.
cord-006439-q7m4srvp	103	1	Recently	recently	RB
cord-006439-q7m4srvp	103	2	,	,	,
cord-006439-q7m4srvp	103	3	Gatineau	Gatineau	NNP
cord-006439-q7m4srvp	103	4	et	et	NNP
cord-006439-q7m4srvp	103	5	al	al	NNP
cord-006439-q7m4srvp	103	6	.	.	NNP
cord-006439-q7m4srvp	103	7	demonstrated	demonstrate	VBD
cord-006439-q7m4srvp	103	8	that	that	IN
cord-006439-q7m4srvp	103	9	the	the	DT
cord-006439-q7m4srvp	103	10	selective	selective	JJ
cord-006439-q7m4srvp	103	11	deletion	deletion	NN
cord-006439-q7m4srvp	103	12	of	of	IN
cord-006439-q7m4srvp	103	13	adipose	adipose	JJ
cord-006439-q7m4srvp	103	14	tissue	tissue	NN
cord-006439-q7m4srvp	103	15	PRR	PRR	NNP
cord-006439-q7m4srvp	103	16	elevates	elevate	VBZ
cord-006439-q7m4srvp	103	17	systolic	systolic	JJ
cord-006439-q7m4srvp	103	18	blood	blood	NN
cord-006439-q7m4srvp	103	19	pressure	pressure	NN
cord-006439-q7m4srvp	103	20	concomitant	concomitant	JJ
cord-006439-q7m4srvp	103	21	with	with	IN
cord-006439-q7m4srvp	103	22	increased	increase	VBN
cord-006439-q7m4srvp	103	23	circulating	circulate	VBG
cord-006439-q7m4srvp	103	24	sPRR	sprr	JJ
cord-006439-q7m4srvp	103	25	levels	level	NNS
cord-006439-q7m4srvp	103	26	in	in	IN
cord-006439-q7m4srvp	103	27	high	high	JJ
cord-006439-q7m4srvp	103	28	fat	fat	NN
cord-006439-q7m4srvp	103	29	diet	diet	NN
cord-006439-q7m4srvp	103	30	-	-	HYPH
cord-006439-q7m4srvp	103	31	fed	feed	VBN
cord-006439-q7m4srvp	103	32	mice	mouse	NNS
cord-006439-q7m4srvp	103	33	[	[	-LRB-
cord-006439-q7m4srvp	103	34	85•	85•	CD
cord-006439-q7m4srvp	103	35	]	]	-RRB-
cord-006439-q7m4srvp	103	36	.	.	.
cord-006439-q7m4srvp	104	1	In	in	IN
cord-006439-q7m4srvp	104	2	males	male	NNS
cord-006439-q7m4srvp	104	3	,	,	,
cord-006439-q7m4srvp	104	4	systemic	systemic	JJ
cord-006439-q7m4srvp	104	5	infusion	infusion	NN
cord-006439-q7m4srvp	104	6	of	of	IN
cord-006439-q7m4srvp	104	7	recombinant	recombinant	JJ
cord-006439-q7m4srvp	104	8	mouse	mouse	NN
cord-006439-q7m4srvp	104	9	epitope	epitope	NN
cord-006439-q7m4srvp	104	10	tagged	tagged	NNP
cord-006439-q7m4srvp	104	11	sPRR	sPRR	NNP
cord-006439-q7m4srvp	104	12	resulted	result	VBD
cord-006439-q7m4srvp	104	13	in	in	IN
cord-006439-q7m4srvp	104	14	blood	blood	NN
cord-006439-q7m4srvp	104	15	pressure	pressure	NN
cord-006439-q7m4srvp	104	16	elevation	elevation	NN
cord-006439-q7m4srvp	104	17	and	and	CC
cord-006439-q7m4srvp	104	18	this	this	DT
cord-006439-q7m4srvp	104	19	increase	increase	NN
cord-006439-q7m4srvp	104	20	was	be	VBD
cord-006439-q7m4srvp	104	21	attenuated	attenuate	VBN
cord-006439-q7m4srvp	104	22	by	by	IN
cord-006439-q7m4srvp	104	23	ganglionic	ganglionic	NNP
cord-006439-q7m4srvp	104	24	blockade	blockade	NN
cord-006439-q7m4srvp	104	25	,	,	,
cord-006439-q7m4srvp	104	26	but	but	CC
cord-006439-q7m4srvp	104	27	not	not	RB
cord-006439-q7m4srvp	104	28	administration	administration	NN
cord-006439-q7m4srvp	104	29	of	of	IN
cord-006439-q7m4srvp	104	30	AT	AT	NNP
cord-006439-q7m4srvp	104	31	1	1	CD
cord-006439-q7m4srvp	104	32	R	r	NN
cord-006439-q7m4srvp	104	33	blockers	blocker	NNS
cord-006439-q7m4srvp	104	34	,	,	,
cord-006439-q7m4srvp	104	35	indicating	indicate	VBG
cord-006439-q7m4srvp	104	36	that	that	IN
cord-006439-q7m4srvp	104	37	autonomic	autonomic	JJ
cord-006439-q7m4srvp	104	38	dysfunction	dysfunction	NN
cord-006439-q7m4srvp	104	39	,	,	,
cord-006439-q7m4srvp	104	40	but	but	CC
cord-006439-q7m4srvp	104	41	not	not	RB
cord-006439-q7m4srvp	104	42	circulating	circulate	VBG
cord-006439-q7m4srvp	104	43	RAS	RAS	NNP
cord-006439-q7m4srvp	104	44	overactivation	overactivation	NN
cord-006439-q7m4srvp	104	45	,	,	,
cord-006439-q7m4srvp	104	46	is	be	VBZ
cord-006439-q7m4srvp	104	47	a	a	DT
cord-006439-q7m4srvp	104	48	key	key	JJ
cord-006439-q7m4srvp	104	49	mechanism	mechanism	NN
cord-006439-q7m4srvp	104	50	underlying	underlie	VBG
cord-006439-q7m4srvp	104	51	sPRR	sprr	RB
cord-006439-q7m4srvp	104	52	-	-	HYPH
cord-006439-q7m4srvp	104	53	mediated	mediate	VBN
cord-006439-q7m4srvp	104	54	blood	blood	NN
cord-006439-q7m4srvp	104	55	pressure	pressure	NN
cord-006439-q7m4srvp	104	56	elevation	elevation	NN
cord-006439-q7m4srvp	104	57	in	in	IN
cord-006439-q7m4srvp	104	58	obese	obese	JJ
cord-006439-q7m4srvp	104	59	male	male	JJ
cord-006439-q7m4srvp	104	60	mice	mouse	NNS
cord-006439-q7m4srvp	104	61	.	.	.
cord-006439-q7m4srvp	105	1	In	in	IN
cord-006439-q7m4srvp	105	2	contrast	contrast	NN
cord-006439-q7m4srvp	105	3	,	,	,
cord-006439-q7m4srvp	105	4	infusion	infusion	NN
cord-006439-q7m4srvp	105	5	of	of	IN
cord-006439-q7m4srvp	105	6	sPRR	sprr	NN
cord-006439-q7m4srvp	105	7	in	in	IN
cord-006439-q7m4srvp	105	8	females	female	NNS
cord-006439-q7m4srvp	105	9	failed	fail	VBD
cord-006439-q7m4srvp	105	10	to	to	TO
cord-006439-q7m4srvp	105	11	induce	induce	VB
cord-006439-q7m4srvp	105	12	autonomic	autonomic	JJ
cord-006439-q7m4srvp	105	13	dysfunction	dysfunction	NN
cord-006439-q7m4srvp	105	14	but	but	CC
cord-006439-q7m4srvp	105	15	it	-PRON-	PRP
cord-006439-q7m4srvp	105	16	induced	induce	VBD
cord-006439-q7m4srvp	105	17	elevated	elevated	JJ
cord-006439-q7m4srvp	105	18	vasopressin	vasopressin	NN
cord-006439-q7m4srvp	105	19	levels	level	NNS
cord-006439-q7m4srvp	105	20	and	and	CC
cord-006439-q7m4srvp	105	21	plasma	plasma	NN
cord-006439-q7m4srvp	105	22	renin	renin	NN
cord-006439-q7m4srvp	105	23	indicating	indicate	VBG
cord-006439-q7m4srvp	105	24	the	the	DT
cord-006439-q7m4srvp	105	25	existence	existence	NN
cord-006439-q7m4srvp	105	26	of	of	IN
cord-006439-q7m4srvp	105	27	sex	sex	NN
cord-006439-q7m4srvp	105	28	differences	difference	NNS
cord-006439-q7m4srvp	105	29	in	in	IN
cord-006439-q7m4srvp	105	30	sPRR	sprr	RB
cord-006439-q7m4srvp	105	31	-	-	HYPH
cord-006439-q7m4srvp	105	32	mediated	mediate	VBN
cord-006439-q7m4srvp	105	33	responses	response	NNS
cord-006439-q7m4srvp	105	34	[	[	-LRB-
cord-006439-q7m4srvp	105	35	86	86	CD
cord-006439-q7m4srvp	105	36	]	]	-RRB-
cord-006439-q7m4srvp	105	37	.	.	.
cord-006439-q7m4srvp	106	1	Given	give	VBN
cord-006439-q7m4srvp	106	2	that	that	IN
cord-006439-q7m4srvp	106	3	the	the	DT
cord-006439-q7m4srvp	106	4	source	source	NN
cord-006439-q7m4srvp	106	5	of	of	IN
cord-006439-q7m4srvp	106	6	vasopressin	vasopressin	NN
cord-006439-q7m4srvp	106	7	is	be	VBZ
cord-006439-q7m4srvp	106	8	exclusively	exclusively	RB
cord-006439-q7m4srvp	106	9	from	from	IN
cord-006439-q7m4srvp	106	10	the	the	DT
cord-006439-q7m4srvp	106	11	PVN	PVN	NNP
cord-006439-q7m4srvp	106	12	and	and	CC
cord-006439-q7m4srvp	106	13	supraoptic	supraoptic	JJ
cord-006439-q7m4srvp	106	14	nucleus	nucleus	NN
cord-006439-q7m4srvp	106	15	(	(	-LRB-
cord-006439-q7m4srvp	106	16	SON	SON	NNP
cord-006439-q7m4srvp	106	17	)	)	-RRB-
cord-006439-q7m4srvp	106	18	,	,	,
cord-006439-q7m4srvp	106	19	these	these	DT
cord-006439-q7m4srvp	106	20	observations	observation	NNS
cord-006439-q7m4srvp	106	21	support	support	VBP
cord-006439-q7m4srvp	106	22	that	that	IN
cord-006439-q7m4srvp	106	23	sPRR	sprr	NN
cord-006439-q7m4srvp	106	24	is	be	VBZ
cord-006439-q7m4srvp	106	25	biologically	biologically	RB
cord-006439-q7m4srvp	106	26	active	active	JJ
cord-006439-q7m4srvp	106	27	in	in	IN
cord-006439-q7m4srvp	106	28	the	the	DT
cord-006439-q7m4srvp	106	29	CNS	CNS	NNP
cord-006439-q7m4srvp	106	30	and	and	CC
cord-006439-q7m4srvp	106	31	elevations	elevation	NNS
cord-006439-q7m4srvp	106	32	of	of	IN
cord-006439-q7m4srvp	106	33	sPRR	sprr	CD
cord-006439-q7m4srvp	106	34	in	in	IN
cord-006439-q7m4srvp	106	35	the	the	DT
cord-006439-q7m4srvp	106	36	brain	brain	NN
cord-006439-q7m4srvp	106	37	might	may	MD
cord-006439-q7m4srvp	106	38	be	be	VB
cord-006439-q7m4srvp	106	39	implicated	implicate	VBN
cord-006439-q7m4srvp	106	40	in	in	IN
cord-006439-q7m4srvp	106	41	certain	certain	JJ
cord-006439-q7m4srvp	106	42	forms	form	NNS
cord-006439-q7m4srvp	106	43	of	of	IN
cord-006439-q7m4srvp	106	44	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	106	45	hypertension	hypertension	NN
cord-006439-q7m4srvp	106	46	linked	link	VBN
cord-006439-q7m4srvp	106	47	to	to	IN
cord-006439-q7m4srvp	106	48	obesity	obesity	NN
cord-006439-q7m4srvp	106	49	.	.	.
cord-006439-q7m4srvp	107	1	It	-PRON-	PRP
cord-006439-q7m4srvp	107	2	has	have	VBZ
cord-006439-q7m4srvp	107	3	been	be	VBN
cord-006439-q7m4srvp	107	4	proposed	propose	VBN
cord-006439-q7m4srvp	107	5	that	that	IN
cord-006439-q7m4srvp	107	6	many	many	JJ
cord-006439-q7m4srvp	107	7	of	of	IN
cord-006439-q7m4srvp	107	8	the	the	DT
cord-006439-q7m4srvp	107	9	effects	effect	NNS
cord-006439-q7m4srvp	107	10	of	of	IN
cord-006439-q7m4srvp	107	11	ANG-(1	ang-(1	CD
cord-006439-q7m4srvp	107	12	-	-	SYM
cord-006439-q7m4srvp	107	13	7	7	CD
cord-006439-q7m4srvp	107	14	)	)	-RRB-
cord-006439-q7m4srvp	107	15	in	in	IN
cord-006439-q7m4srvp	107	16	the	the	DT
cord-006439-q7m4srvp	107	17	CNS	CNS	NNP
cord-006439-q7m4srvp	107	18	oppose	oppose	VBP
cord-006439-q7m4srvp	107	19	many	many	JJ
cord-006439-q7m4srvp	107	20	of	of	IN
cord-006439-q7m4srvp	107	21	the	the	DT
cord-006439-q7m4srvp	107	22	AT	AT	NNP
cord-006439-q7m4srvp	107	23	1	1	CD
cord-006439-q7m4srvp	107	24	R	r	NN
cord-006439-q7m4srvp	107	25	-	-	HYPH
cord-006439-q7m4srvp	107	26	mediated	mediate	VBN
cord-006439-q7m4srvp	107	27	actions	action	NNS
cord-006439-q7m4srvp	107	28	of	of	IN
cord-006439-q7m4srvp	107	29	ANG	ANG	NNP
cord-006439-q7m4srvp	107	30	-	-	HYPH
cord-006439-q7m4srvp	107	31	II	II	NNP
cord-006439-q7m4srvp	107	32	in	in	IN
cord-006439-q7m4srvp	107	33	the	the	DT
cord-006439-q7m4srvp	107	34	brain	brain	NN
cord-006439-q7m4srvp	107	35	[	[	-LRB-
cord-006439-q7m4srvp	107	36	87	87	CD
cord-006439-q7m4srvp	107	37	]	]	-RRB-
cord-006439-q7m4srvp	107	38	.	.	.
cord-006439-q7m4srvp	108	1	ANG-(1	ang-(1	CD
cord-006439-q7m4srvp	108	2	-	-	SYM
cord-006439-q7m4srvp	108	3	7	7	CD
cord-006439-q7m4srvp	108	4	)	)	-RRB-
cord-006439-q7m4srvp	108	5	induces	induce	VBZ
cord-006439-q7m4srvp	108	6	its	-PRON-	PRP$
cord-006439-q7m4srvp	108	7	effects	effect	NNS
cord-006439-q7m4srvp	108	8	mainly	mainly	RB
cord-006439-q7m4srvp	108	9	through	through	IN
cord-006439-q7m4srvp	108	10	Mas	Mas	NNP
cord-006439-q7m4srvp	108	11	receptor	receptor	NN
cord-006439-q7m4srvp	108	12	activation	activation	NN
cord-006439-q7m4srvp	108	13	,	,	,
cord-006439-q7m4srvp	108	14	although	although	IN
cord-006439-q7m4srvp	108	15	it	-PRON-	PRP
cord-006439-q7m4srvp	108	16	has	have	VBZ
cord-006439-q7m4srvp	108	17	been	be	VBN
cord-006439-q7m4srvp	108	18	reported	report	VBN
cord-006439-q7m4srvp	108	19	to	to	TO
cord-006439-q7m4srvp	108	20	also	also	RB
cord-006439-q7m4srvp	108	21	act	act	VB
cord-006439-q7m4srvp	108	22	through	through	IN
cord-006439-q7m4srvp	108	23	AT	AT	NNP
cord-006439-q7m4srvp	108	24	2	2	CD
cord-006439-q7m4srvp	108	25	R	r	NN
cord-006439-q7m4srvp	108	26	[	[	-LRB-
cord-006439-q7m4srvp	108	27	88	88	CD
cord-006439-q7m4srvp	108	28	]	]	-RRB-
cord-006439-q7m4srvp	108	29	.	.	.
cord-006439-q7m4srvp	109	1	Other	other	JJ
cord-006439-q7m4srvp	109	2	studies	study	NNS
cord-006439-q7m4srvp	109	3	proposed	propose	VBD
cord-006439-q7m4srvp	109	4	that	that	IN
cord-006439-q7m4srvp	109	5	Mas	Mas	NNP
cord-006439-q7m4srvp	109	6	receptors	receptor	NNS
cord-006439-q7m4srvp	109	7	form	form	VBP
cord-006439-q7m4srvp	109	8	heterodimers	heterodimer	NNS
cord-006439-q7m4srvp	109	9	with	with	IN
cord-006439-q7m4srvp	109	10	AT	at	IN
cord-006439-q7m4srvp	109	11	2	2	CD
cord-006439-q7m4srvp	109	12	R	r	NN
cord-006439-q7m4srvp	109	13	in	in	IN
cord-006439-q7m4srvp	109	14	astrocytes	astrocyte	NNS
cord-006439-q7m4srvp	109	15	[	[	-LRB-
cord-006439-q7m4srvp	109	16	89	89	CD
cord-006439-q7m4srvp	109	17	]	]	-RRB-
cord-006439-q7m4srvp	109	18	.	.	.
cord-006439-q7m4srvp	110	1	Teixeira	Teixeira	NNP
cord-006439-q7m4srvp	110	2	et	et	NNP
cord-006439-q7m4srvp	110	3	al	al	NNP
cord-006439-q7m4srvp	110	4	.	.	.
cord-006439-q7m4srvp	111	1	recently	recently	RB
cord-006439-q7m4srvp	111	2	reported	report	VBD
cord-006439-q7m4srvp	111	3	that	that	IN
cord-006439-q7m4srvp	111	4	ANG-(1	ANG-(1	NNP
cord-006439-q7m4srvp	111	5	-	-	SYM
cord-006439-q7m4srvp	111	6	7	7	CD
cord-006439-q7m4srvp	111	7	)	)	-RRB-
cord-006439-q7m4srvp	111	8	binds	bind	VBZ
cord-006439-q7m4srvp	111	9	to	to	IN
cord-006439-q7m4srvp	111	10	AT	at	NN
cord-006439-q7m4srvp	111	11	1	1	CD
cord-006439-q7m4srvp	111	12	R	r	NN
cord-006439-q7m4srvp	111	13	but	but	CC
cord-006439-q7m4srvp	111	14	fails	fail	VBZ
cord-006439-q7m4srvp	111	15	to	to	TO
cord-006439-q7m4srvp	111	16	engage	engage	VB
cord-006439-q7m4srvp	111	17	its	-PRON-	PRP$
cord-006439-q7m4srvp	111	18	canonical	canonical	JJ
cord-006439-q7m4srvp	111	19	G	g	NN
cord-006439-q7m4srvp	111	20	protein	protein	NN
cord-006439-q7m4srvp	111	21	signaling	signal	VBG
cord-006439-q7m4srvp	111	22	[	[	-LRB-
cord-006439-q7m4srvp	111	23	90	90	CD
cord-006439-q7m4srvp	111	24	]	]	-RRB-
cord-006439-q7m4srvp	111	25	.	.	.
cord-006439-q7m4srvp	112	1	Instead	instead	RB
cord-006439-q7m4srvp	112	2	,	,	,
cord-006439-q7m4srvp	112	3	ANG-(1	ang-(1	CD
cord-006439-q7m4srvp	112	4	-	-	SYM
cord-006439-q7m4srvp	112	5	7	7	CD
cord-006439-q7m4srvp	112	6	)	)	-RRB-
cord-006439-q7m4srvp	112	7	triggers	trigger	VBZ
cord-006439-q7m4srvp	112	8	β	β	XX
cord-006439-q7m4srvp	112	9	-	-	HYPH
cord-006439-q7m4srvp	112	10	arrestin	arrestin	NN
cord-006439-q7m4srvp	112	11	recruitment	recruitment	NN
cord-006439-q7m4srvp	112	12	and	and	CC
cord-006439-q7m4srvp	112	13	intracellular	intracellular	JJ
cord-006439-q7m4srvp	112	14	signaling	signaling	NN
cord-006439-q7m4srvp	112	15	,	,	,
cord-006439-q7m4srvp	112	16	suggesting	suggest	VBG
cord-006439-q7m4srvp	112	17	it	-PRON-	PRP
cord-006439-q7m4srvp	112	18	may	may	MD
cord-006439-q7m4srvp	112	19	have	have	VB
cord-006439-q7m4srvp	112	20	the	the	DT
cord-006439-q7m4srvp	112	21	properties	property	NNS
cord-006439-q7m4srvp	112	22	of	of	IN
cord-006439-q7m4srvp	112	23	a	a	DT
cord-006439-q7m4srvp	112	24	biased	biased	JJ
cord-006439-q7m4srvp	112	25	agonist	agonist	NN
cord-006439-q7m4srvp	112	26	for	for	IN
cord-006439-q7m4srvp	112	27	AT	AT	NNP
cord-006439-q7m4srvp	112	28	1	1	CD
cord-006439-q7m4srvp	113	1	R.	R.	NNP
cord-006439-q7m4srvp	113	2	Several	several	JJ
cord-006439-q7m4srvp	113	3	synthetic	synthetic	NN
cord-006439-q7m4srvp	113	4	AT	AT	NNP
cord-006439-q7m4srvp	113	5	1	1	CD
cord-006439-q7m4srvp	113	6	R	r	NN
cord-006439-q7m4srvp	113	7	biased	bias	VBN
cord-006439-q7m4srvp	113	8	agonists	agonist	NNS
cord-006439-q7m4srvp	113	9	have	have	VBP
cord-006439-q7m4srvp	113	10	been	be	VBN
cord-006439-q7m4srvp	113	11	designed	design	VBN
cord-006439-q7m4srvp	113	12	,	,	,
cord-006439-q7m4srvp	113	13	but	but	CC
cord-006439-q7m4srvp	113	14	the	the	DT
cord-006439-q7m4srvp	113	15	existence	existence	NN
cord-006439-q7m4srvp	113	16	of	of	IN
cord-006439-q7m4srvp	113	17	an	an	DT
cord-006439-q7m4srvp	113	18	endogenous	endogenous	JJ
cord-006439-q7m4srvp	113	19	functional	functional	JJ
cord-006439-q7m4srvp	113	20	biased	biased	JJ
cord-006439-q7m4srvp	113	21	ligand	ligand	NN
cord-006439-q7m4srvp	113	22	for	for	IN
cord-006439-q7m4srvp	113	23	AT	at	NN
cord-006439-q7m4srvp	113	24	1	1	CD
cord-006439-q7m4srvp	113	25	R	r	NN
cord-006439-q7m4srvp	113	26	has	have	VBZ
cord-006439-q7m4srvp	113	27	not	not	RB
cord-006439-q7m4srvp	113	28	been	be	VBN
cord-006439-q7m4srvp	113	29	reported	report	VBN
cord-006439-q7m4srvp	113	30	.	.	.
cord-006439-q7m4srvp	114	1	ANG-(1	ang-(1	CD
cord-006439-q7m4srvp	114	2	-	-	SYM
cord-006439-q7m4srvp	114	3	7	7	CD
cord-006439-q7m4srvp	114	4	)	)	-RRB-
cord-006439-q7m4srvp	114	5	can	can	MD
cord-006439-q7m4srvp	114	6	be	be	VB
cord-006439-q7m4srvp	114	7	generated	generate	VBN
cord-006439-q7m4srvp	114	8	from	from	IN
cord-006439-q7m4srvp	114	9	the	the	DT
cord-006439-q7m4srvp	114	10	direct	direct	JJ
cord-006439-q7m4srvp	114	11	cleavage	cleavage	NN
cord-006439-q7m4srvp	114	12	of	of	IN
cord-006439-q7m4srvp	114	13	ANG	ANG	NNP
cord-006439-q7m4srvp	114	14	-	-	HYPH
cord-006439-q7m4srvp	114	15	II	II	NNP
cord-006439-q7m4srvp	114	16	by	by	IN
cord-006439-q7m4srvp	114	17	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	114	18	converting	convert	VBG
cord-006439-q7m4srvp	114	19	enzyme	enzyme	NN
cord-006439-q7m4srvp	114	20	2	2	CD
cord-006439-q7m4srvp	114	21	(	(	-LRB-
cord-006439-q7m4srvp	114	22	ACE2	ACE2	NNP
cord-006439-q7m4srvp	114	23	)	)	-RRB-
cord-006439-q7m4srvp	114	24	,	,	,
cord-006439-q7m4srvp	114	25	but	but	CC
cord-006439-q7m4srvp	114	26	ACE2	ACE2	NNP
cord-006439-q7m4srvp	114	27	can	can	MD
cord-006439-q7m4srvp	114	28	also	also	RB
cord-006439-q7m4srvp	114	29	catalyze	catalyze	VB
cord-006439-q7m4srvp	114	30	the	the	DT
cord-006439-q7m4srvp	114	31	conversion	conversion	NN
cord-006439-q7m4srvp	114	32	of	of	IN
cord-006439-q7m4srvp	114	33	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	114	34	I	-PRON-	PRP
cord-006439-q7m4srvp	114	35	to	to	IN
cord-006439-q7m4srvp	114	36	Angiotensin-(1	Angiotensin-(1	NNP
cord-006439-q7m4srvp	114	37	-	-	HYPH
cord-006439-q7m4srvp	114	38	9	9	CD
cord-006439-q7m4srvp	114	39	)	)	-RRB-
cord-006439-q7m4srvp	114	40	,	,	,
cord-006439-q7m4srvp	114	41	which	which	WDT
cord-006439-q7m4srvp	114	42	subsequently	subsequently	RB
cord-006439-q7m4srvp	114	43	is	be	VBZ
cord-006439-q7m4srvp	114	44	converted	convert	VBN
cord-006439-q7m4srvp	114	45	to	to	IN
cord-006439-q7m4srvp	114	46	ANG-(1	ang-(1	CD
cord-006439-q7m4srvp	114	47	-	-	SYM
cord-006439-q7m4srvp	114	48	7	7	CD
cord-006439-q7m4srvp	114	49	)	)	-RRB-
cord-006439-q7m4srvp	114	50	by	by	IN
cord-006439-q7m4srvp	114	51	ACE	ACE	NNP
cord-006439-q7m4srvp	114	52	or	or	CC
cord-006439-q7m4srvp	114	53	neutral	neutral	JJ
cord-006439-q7m4srvp	114	54	endopeptidase	endopeptidase	NN
cord-006439-q7m4srvp	114	55	[	[	-LRB-
cord-006439-q7m4srvp	114	56	91	91	CD
cord-006439-q7m4srvp	114	57	]	]	-RRB-
cord-006439-q7m4srvp	114	58	.	.	.
cord-006439-q7m4srvp	115	1	Downregulation	Downregulation	NNP
cord-006439-q7m4srvp	115	2	of	of	IN
cord-006439-q7m4srvp	115	3	ACE2	ACE2	NNP
cord-006439-q7m4srvp	115	4	and	and	CC
cord-006439-q7m4srvp	115	5	suppression	suppression	NN
cord-006439-q7m4srvp	115	6	of	of	IN
cord-006439-q7m4srvp	115	7	central	central	JJ
cord-006439-q7m4srvp	115	8	ANG-(1	ANG-(1	NNP
cord-006439-q7m4srvp	115	9	-	-	SYM
cord-006439-q7m4srvp	115	10	7	7	CD
cord-006439-q7m4srvp	115	11	)	)	-RRB-
cord-006439-q7m4srvp	115	12	levels	level	NNS
cord-006439-q7m4srvp	115	13	are	be	VBP
cord-006439-q7m4srvp	115	14	thought	think	VBN
cord-006439-q7m4srvp	115	15	to	to	TO
cord-006439-q7m4srvp	115	16	be	be	VB
cord-006439-q7m4srvp	115	17	one	one	CD
cord-006439-q7m4srvp	115	18	of	of	IN
cord-006439-q7m4srvp	115	19	the	the	DT
cord-006439-q7m4srvp	115	20	underlying	underlie	VBG
cord-006439-q7m4srvp	115	21	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	115	22	causing	cause	VBG
cord-006439-q7m4srvp	115	23	low	low	JJ
cord-006439-q7m4srvp	115	24	renin	renin	NN
cord-006439-q7m4srvp	115	25	hypertension	hypertension	NN
cord-006439-q7m4srvp	115	26	[	[	-LRB-
cord-006439-q7m4srvp	115	27	20	20	CD
cord-006439-q7m4srvp	115	28	,	,	,
cord-006439-q7m4srvp	115	29	92	92	CD
cord-006439-q7m4srvp	115	30	]	]	-RRB-
cord-006439-q7m4srvp	115	31	.	.	.
cord-006439-q7m4srvp	116	1	In	in	IN
cord-006439-q7m4srvp	116	2	recent	recent	JJ
cord-006439-q7m4srvp	116	3	years	year	NNS
cord-006439-q7m4srvp	116	4	,	,	,
cord-006439-q7m4srvp	116	5	significant	significant	JJ
cord-006439-q7m4srvp	116	6	progress	progress	NN
cord-006439-q7m4srvp	116	7	has	have	VBZ
cord-006439-q7m4srvp	116	8	been	be	VBN
cord-006439-q7m4srvp	116	9	achieved	achieve	VBN
cord-006439-q7m4srvp	116	10	particularly	particularly	RB
cord-006439-q7m4srvp	116	11	on	on	IN
cord-006439-q7m4srvp	116	12	the	the	DT
cord-006439-q7m4srvp	116	13	molecular	molecular	JJ
cord-006439-q7m4srvp	116	14	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	116	15	controlling	control	VBG
cord-006439-q7m4srvp	116	16	brain	brain	NN
cord-006439-q7m4srvp	116	17	ACE2	ACE2	NNP
cord-006439-q7m4srvp	116	18	activity	activity	NN
cord-006439-q7m4srvp	116	19	.	.	.
cord-006439-q7m4srvp	117	1	Lambert	Lambert	NNP
cord-006439-q7m4srvp	117	2	et	et	NNP
cord-006439-q7m4srvp	117	3	al	al	NNP
cord-006439-q7m4srvp	117	4	.	.	.
cord-006439-q7m4srvp	118	1	described	describe	VBD
cord-006439-q7m4srvp	118	2	a	a	DT
cord-006439-q7m4srvp	118	3	process	process	NN
cord-006439-q7m4srvp	118	4	termed	term	VBN
cord-006439-q7m4srvp	118	5	"	"	``
cord-006439-q7m4srvp	118	6	ACE2	ACE2	NNP
cord-006439-q7m4srvp	118	7	shedding	shedding	NN
cord-006439-q7m4srvp	118	8	"	"	''
cord-006439-q7m4srvp	118	9	in	in	IN
cord-006439-q7m4srvp	118	10	which	which	WDT
cord-006439-q7m4srvp	118	11	a	a	DT
cord-006439-q7m4srvp	118	12	disintegrin	disintegrin	NNP
cord-006439-q7m4srvp	118	13	and	and	CC
cord-006439-q7m4srvp	118	14	metalloprotease	metalloprotease	NNP
cord-006439-q7m4srvp	118	15	17	17	CD
cord-006439-q7m4srvp	119	1	(	(	-LRB-
cord-006439-q7m4srvp	119	2	ADAM17	adam17	LS
cord-006439-q7m4srvp	119	3	)	)	-RRB-
cord-006439-q7m4srvp	119	4	catalyze	catalyze	VB
cord-006439-q7m4srvp	119	5	the	the	DT
cord-006439-q7m4srvp	119	6	cleavage	cleavage	NN
cord-006439-q7m4srvp	119	7	of	of	IN
cord-006439-q7m4srvp	119	8	membrane	membrane	NN
cord-006439-q7m4srvp	119	9	anchored	anchor	VBN
cord-006439-q7m4srvp	119	10	ACE2	ACE2	NNP
cord-006439-q7m4srvp	119	11	[	[	-LRB-
cord-006439-q7m4srvp	119	12	93	93	CD
cord-006439-q7m4srvp	119	13	]	]	-RRB-
cord-006439-q7m4srvp	119	14	.	.	.
cord-006439-q7m4srvp	120	1	However	however	RB
cord-006439-q7m4srvp	120	2	,	,	,
cord-006439-q7m4srvp	120	3	advances	advance	VBZ
cord-006439-q7m4srvp	120	4	on	on	IN
cord-006439-q7m4srvp	120	5	the	the	DT
cord-006439-q7m4srvp	120	6	physiological	physiological	JJ
cord-006439-q7m4srvp	120	7	and	and	CC
cord-006439-q7m4srvp	120	8	pathophysiological	pathophysiological	JJ
cord-006439-q7m4srvp	120	9	role	role	NN
cord-006439-q7m4srvp	120	10	of	of	IN
cord-006439-q7m4srvp	120	11	ADAM17-mediated	ADAM17-mediated	NNP
cord-006439-q7m4srvp	120	12	ACE2	ACE2	NNP
cord-006439-q7m4srvp	120	13	shedding	shed	VBG
cord-006439-q7m4srvp	120	14	in	in	IN
cord-006439-q7m4srvp	120	15	the	the	DT
cord-006439-q7m4srvp	120	16	brain	brain	NN
cord-006439-q7m4srvp	120	17	have	have	VBP
cord-006439-q7m4srvp	120	18	only	only	RB
cord-006439-q7m4srvp	120	19	been	be	VBN
cord-006439-q7m4srvp	120	20	recently	recently	RB
cord-006439-q7m4srvp	120	21	demonstrated	demonstrate	VBN
cord-006439-q7m4srvp	120	22	.	.	.
cord-006439-q7m4srvp	121	1	Xia	Xia	NNP
cord-006439-q7m4srvp	121	2	and	and	CC
cord-006439-q7m4srvp	121	3	Sriramula	Sriramula	NNP
cord-006439-q7m4srvp	121	4	et	et	NNP
cord-006439-q7m4srvp	121	5	al	al	NNP
cord-006439-q7m4srvp	121	6	.	.	NNP
cord-006439-q7m4srvp	121	7	demonstrated	demonstrate	VBD
cord-006439-q7m4srvp	121	8	that	that	IN
cord-006439-q7m4srvp	121	9	neuron	neuron	NN
cord-006439-q7m4srvp	121	10	-	-	HYPH
cord-006439-q7m4srvp	121	11	targeted	target	VBN
cord-006439-q7m4srvp	121	12	overexpression	overexpression	NN
cord-006439-q7m4srvp	121	13	of	of	IN
cord-006439-q7m4srvp	121	14	ACE2	ACE2	NNP
cord-006439-q7m4srvp	121	15	is	be	VBZ
cord-006439-q7m4srvp	121	16	sufficient	sufficient	JJ
cord-006439-q7m4srvp	121	17	to	to	TO
cord-006439-q7m4srvp	121	18	ameliorate	ameliorate	VB
cord-006439-q7m4srvp	121	19	elevated	elevated	JJ
cord-006439-q7m4srvp	121	20	blood	blood	NN
cord-006439-q7m4srvp	121	21	pressure	pressure	NN
cord-006439-q7m4srvp	121	22	,	,	,
cord-006439-q7m4srvp	121	23	autonomic	autonomic	JJ
cord-006439-q7m4srvp	121	24	dysfunction	dysfunction	NN
cord-006439-q7m4srvp	121	25	,	,	,
cord-006439-q7m4srvp	121	26	and	and	CC
cord-006439-q7m4srvp	121	27	vasopressin	vasopressin	NN
cord-006439-q7m4srvp	121	28	release	release	NN
cord-006439-q7m4srvp	121	29	in	in	IN
cord-006439-q7m4srvp	121	30	response	response	NN
cord-006439-q7m4srvp	121	31	to	to	IN
cord-006439-q7m4srvp	121	32	DOCA	DOCA	NNP
cord-006439-q7m4srvp	121	33	-	-	HYPH
cord-006439-q7m4srvp	121	34	salt	salt	NN
cord-006439-q7m4srvp	121	35	hypertension	hypertension	NN
cord-006439-q7m4srvp	121	36	[	[	-LRB-
cord-006439-q7m4srvp	121	37	94	94	CD
cord-006439-q7m4srvp	121	38	]	]	-RRB-
cord-006439-q7m4srvp	121	39	.	.	.
cord-006439-q7m4srvp	122	1	Moreover	moreover	RB
cord-006439-q7m4srvp	122	2	,	,	,
cord-006439-q7m4srvp	122	3	braintargeted	braintargeted	JJ
cord-006439-q7m4srvp	122	4	ablation	ablation	NN
cord-006439-q7m4srvp	122	5	of	of	IN
cord-006439-q7m4srvp	122	6	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	122	7	utilizing	utilize	VBG
cord-006439-q7m4srvp	122	8	central	central	JJ
cord-006439-q7m4srvp	122	9	infusions	infusion	NNS
cord-006439-q7m4srvp	122	10	of	of	IN
cord-006439-q7m4srvp	122	11	siRNA	siRNA	NNP
cord-006439-q7m4srvp	122	12	suppressed	suppress	VBD
cord-006439-q7m4srvp	122	13	DOCA	DOCA	NNP
cord-006439-q7m4srvp	122	14	-	-	HYPH
cord-006439-q7m4srvp	122	15	salt	salt	NN
cord-006439-q7m4srvp	122	16	induced	induce	VBN
cord-006439-q7m4srvp	122	17	hypertension	hypertension	NN
cord-006439-q7m4srvp	122	18	concomitant	concomitant	JJ
cord-006439-q7m4srvp	122	19	with	with	IN
cord-006439-q7m4srvp	122	20	blunted	blunted	JJ
cord-006439-q7m4srvp	122	21	reduction	reduction	NN
cord-006439-q7m4srvp	122	22	of	of	IN
cord-006439-q7m4srvp	122	23	ACE2	ACE2	NNP
cord-006439-q7m4srvp	122	24	activity	activity	NN
cord-006439-q7m4srvp	122	25	in	in	IN
cord-006439-q7m4srvp	122	26	the	the	DT
cord-006439-q7m4srvp	122	27	hypothalamus	hypothalamus	NN
cord-006439-q7m4srvp	122	28	and	and	CC
cord-006439-q7m4srvp	122	29	cerebrospinal	cerebrospinal	NN
cord-006439-q7m4srvp	122	30	fluid	fluid	NN
cord-006439-q7m4srvp	122	31	,	,	,
cord-006439-q7m4srvp	122	32	indicating	indicate	VBG
cord-006439-q7m4srvp	122	33	that	that	IN
cord-006439-q7m4srvp	122	34	ACE2	ACE2	NNP
cord-006439-q7m4srvp	122	35	shedding	shed	VBG
cord-006439-q7m4srvp	122	36	by	by	IN
cord-006439-q7m4srvp	122	37	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	122	38	in	in	IN
cord-006439-q7m4srvp	122	39	the	the	DT
cord-006439-q7m4srvp	122	40	brain	brain	NN
cord-006439-q7m4srvp	122	41	is	be	VBZ
cord-006439-q7m4srvp	122	42	a	a	DT
cord-006439-q7m4srvp	122	43	relevant	relevant	JJ
cord-006439-q7m4srvp	122	44	mechanism	mechanism	NN
cord-006439-q7m4srvp	122	45	contributing	contribute	VBG
cord-006439-q7m4srvp	122	46	to	to	IN
cord-006439-q7m4srvp	122	47	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	122	48	hypertension	hypertension	NN
cord-006439-q7m4srvp	122	49	.	.	.
cord-006439-q7m4srvp	123	1	New	new	JJ
cord-006439-q7m4srvp	123	2	evidence	evidence	NN
cord-006439-q7m4srvp	123	3	indicates	indicate	VBZ
cord-006439-q7m4srvp	123	4	that	that	IN
cord-006439-q7m4srvp	123	5	activation	activation	NN
cord-006439-q7m4srvp	123	6	of	of	IN
cord-006439-q7m4srvp	123	7	AT	at	NN
cord-006439-q7m4srvp	123	8	1	1	CD
cord-006439-q7m4srvp	123	9	R	r	NN
cord-006439-q7m4srvp	123	10	is	be	VBZ
cord-006439-q7m4srvp	123	11	required	require	VBN
cord-006439-q7m4srvp	123	12	for	for	IN
cord-006439-q7m4srvp	123	13	ADAM17-mediated	ADAM17-mediated	NNP
cord-006439-q7m4srvp	123	14	ACE2	ACE2	NNP
cord-006439-q7m4srvp	123	15	shedding	shed	VBG
cord-006439-q7m4srvp	123	16	possibly	possibly	RB
cord-006439-q7m4srvp	123	17	via	via	IN
cord-006439-q7m4srvp	123	18	reactive	reactive	JJ
cord-006439-q7m4srvp	123	19	oxygen	oxygen	NN
cord-006439-q7m4srvp	123	20	species	specie	NNS
cord-006439-q7m4srvp	123	21	and	and	CC
cord-006439-q7m4srvp	123	22	phosphorylation	phosphorylation	NN
cord-006439-q7m4srvp	123	23	of	of	IN
cord-006439-q7m4srvp	123	24	extracellular	extracellular	JJ
cord-006439-q7m4srvp	123	25	signal	signal	NN
cord-006439-q7m4srvp	123	26	-	-	HYPH
cord-006439-q7m4srvp	123	27	regulated	regulate	VBN
cord-006439-q7m4srvp	123	28	kinase	kinase	NN
cord-006439-q7m4srvp	123	29	in	in	IN
cord-006439-q7m4srvp	123	30	neurons	neuron	NNS
cord-006439-q7m4srvp	123	31	[	[	-LRB-
cord-006439-q7m4srvp	123	32	92	92	CD
cord-006439-q7m4srvp	123	33	]	]	-RRB-
cord-006439-q7m4srvp	123	34	.	.	.
cord-006439-q7m4srvp	124	1	It	-PRON-	PRP
cord-006439-q7m4srvp	124	2	has	have	VBZ
cord-006439-q7m4srvp	124	3	been	be	VBN
cord-006439-q7m4srvp	124	4	previously	previously	RB
cord-006439-q7m4srvp	124	5	shown	show	VBN
cord-006439-q7m4srvp	124	6	that	that	IN
cord-006439-q7m4srvp	124	7	a	a	DT
cord-006439-q7m4srvp	124	8	reduction	reduction	NN
cord-006439-q7m4srvp	124	9	of	of	IN
cord-006439-q7m4srvp	124	10	ACE2	ACE2	NNP
cord-006439-q7m4srvp	124	11	expression	expression	NN
cord-006439-q7m4srvp	124	12	in	in	IN
cord-006439-q7m4srvp	124	13	the	the	DT
cord-006439-q7m4srvp	124	14	RVLM	RVLM	NNP
cord-006439-q7m4srvp	124	15	is	be	VBZ
cord-006439-q7m4srvp	124	16	a	a	DT
cord-006439-q7m4srvp	124	17	contributing	contribute	VBG
cord-006439-q7m4srvp	124	18	factor	factor	NN
cord-006439-q7m4srvp	124	19	in	in	IN
cord-006439-q7m4srvp	124	20	the	the	DT
cord-006439-q7m4srvp	124	21	development	development	NN
cord-006439-q7m4srvp	124	22	of	of	IN
cord-006439-q7m4srvp	124	23	hypertension	hypertension	NN
cord-006439-q7m4srvp	124	24	in	in	IN
cord-006439-q7m4srvp	124	25	spontaneously	spontaneously	RB
cord-006439-q7m4srvp	124	26	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	124	27	rats	rat	NNS
cord-006439-q7m4srvp	124	28	[	[	-LRB-
cord-006439-q7m4srvp	124	29	95	95	CD
cord-006439-q7m4srvp	124	30	]	]	-RRB-
cord-006439-q7m4srvp	124	31	.	.	.
cord-006439-q7m4srvp	125	1	Mukerjee	Mukerjee	NNP
cord-006439-q7m4srvp	125	2	et	et	NNP
cord-006439-q7m4srvp	125	3	al	al	NNP
cord-006439-q7m4srvp	125	4	.	.	.
cord-006439-q7m4srvp	126	1	provided	provide	VBN
cord-006439-q7m4srvp	126	2	evidence	evidence	NN
cord-006439-q7m4srvp	126	3	of	of	IN
cord-006439-q7m4srvp	126	4	the	the	DT
cord-006439-q7m4srvp	126	5	importance	importance	NN
cord-006439-q7m4srvp	126	6	of	of	IN
cord-006439-q7m4srvp	126	7	ACE2/	ACE2/	NNP
cord-006439-q7m4srvp	127	1	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	127	2	pathway	pathway	NN
cord-006439-q7m4srvp	127	3	in	in	IN
cord-006439-q7m4srvp	127	4	pre	pre	JJ
cord-006439-q7m4srvp	127	5	-	-	JJ
cord-006439-q7m4srvp	127	6	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	127	7	neurons	neuron	NNS
cord-006439-q7m4srvp	127	8	within	within	IN
cord-006439-q7m4srvp	127	9	the	the	DT
cord-006439-q7m4srvp	127	10	PVN	PVN	NNP
cord-006439-q7m4srvp	127	11	[	[	-LRB-
cord-006439-q7m4srvp	127	12	96•	96•	JJ
cord-006439-q7m4srvp	127	13	]	]	-RRB-
cord-006439-q7m4srvp	127	14	.	.	.
cord-006439-q7m4srvp	128	1	Interestingly	interestingly	RB
cord-006439-q7m4srvp	128	2	,	,	,
cord-006439-q7m4srvp	128	3	ACE2	ACE2	NNP
cord-006439-q7m4srvp	128	4	is	be	VBZ
cord-006439-q7m4srvp	128	5	expressed	express	VBN
cord-006439-q7m4srvp	128	6	in	in	IN
cord-006439-q7m4srvp	128	7	GABAergic	gabaergic	JJ
cord-006439-q7m4srvp	128	8	inhibitory	inhibitory	JJ
cord-006439-q7m4srvp	128	9	neurons	neuron	NNS
cord-006439-q7m4srvp	128	10	projecting	project	VBG
cord-006439-q7m4srvp	128	11	onto	onto	IN
cord-006439-q7m4srvp	128	12	the	the	DT
cord-006439-q7m4srvp	128	13	hypothalamus	hypothalamus	NN
cord-006439-q7m4srvp	128	14	.	.	.
cord-006439-q7m4srvp	129	1	Thus	thus	RB
cord-006439-q7m4srvp	129	2	,	,	,
cord-006439-q7m4srvp	129	3	ACE2	ACE2	NNP
cord-006439-q7m4srvp	129	4	is	be	VBZ
cord-006439-q7m4srvp	129	5	thought	think	VBN
cord-006439-q7m4srvp	129	6	to	to	TO
cord-006439-q7m4srvp	129	7	maintain	maintain	VB
cord-006439-q7m4srvp	129	8	a	a	DT
cord-006439-q7m4srvp	129	9	normal	normal	JJ
cord-006439-q7m4srvp	129	10	GABAergic	gabaergic	NN
cord-006439-q7m4srvp	129	11	inhibitory	inhibitory	JJ
cord-006439-q7m4srvp	129	12	tone	tone	NN
cord-006439-q7m4srvp	129	13	to	to	IN
cord-006439-q7m4srvp	129	14	the	the	DT
cord-006439-q7m4srvp	129	15	presympathetic	presympathetic	JJ
cord-006439-q7m4srvp	129	16	neurons	neuron	NNS
cord-006439-q7m4srvp	129	17	in	in	IN
cord-006439-q7m4srvp	129	18	the	the	DT
cord-006439-q7m4srvp	129	19	PVN	PVN	NNP
cord-006439-q7m4srvp	129	20	in	in	IN
cord-006439-q7m4srvp	129	21	normal	normal	JJ
cord-006439-q7m4srvp	129	22	physiological	physiological	JJ
cord-006439-q7m4srvp	129	23	conditions	condition	NNS
cord-006439-q7m4srvp	129	24	,	,	,
cord-006439-q7m4srvp	129	25	while	while	IN
cord-006439-q7m4srvp	129	26	disinhibition	disinhibition	NN
cord-006439-q7m4srvp	129	27	of	of	IN
cord-006439-q7m4srvp	129	28	this	this	DT
cord-006439-q7m4srvp	129	29	pathway	pathway	NN
cord-006439-q7m4srvp	129	30	might	may	MD
cord-006439-q7m4srvp	129	31	lead	lead	VB
cord-006439-q7m4srvp	129	32	to	to	IN
cord-006439-q7m4srvp	129	33	hypertension	hypertension	NN
cord-006439-q7m4srvp	129	34	.	.	.
cord-006439-q7m4srvp	130	1	In	in	IN
cord-006439-q7m4srvp	130	2	contrast	contrast	NN
cord-006439-q7m4srvp	130	3	,	,	,
cord-006439-q7m4srvp	130	4	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	130	5	is	be	VBZ
cord-006439-q7m4srvp	130	6	expressed	express	VBN
cord-006439-q7m4srvp	130	7	in	in	IN
cord-006439-q7m4srvp	130	8	single	single	JJ
cord-006439-q7m4srvp	130	9	-	-	HYPH
cord-006439-q7m4srvp	130	10	minded	minded	JJ
cord-006439-q7m4srvp	130	11	family	family	NN
cord-006439-q7m4srvp	130	12	basic	basic	JJ
cord-006439-q7m4srvp	130	13	helixloop	helixloop	JJ
cord-006439-q7m4srvp	130	14	helix	helix	NN
cord-006439-q7m4srvp	130	15	transcription	transcription	NN
cord-006439-q7m4srvp	130	16	factor	factor	NN
cord-006439-q7m4srvp	130	17	1	1	CD
cord-006439-q7m4srvp	130	18	(	(	-LRB-
cord-006439-q7m4srvp	130	19	Sim1)-positive	sim1)-positive	JJ
cord-006439-q7m4srvp	130	20	excitatory	excitatory	JJ
cord-006439-q7m4srvp	130	21	neurons	neuron	NNS
cord-006439-q7m4srvp	130	22	within	within	IN
cord-006439-q7m4srvp	130	23	the	the	DT
cord-006439-q7m4srvp	130	24	PVN	PVN	NNP
cord-006439-q7m4srvp	130	25	and	and	CC
cord-006439-q7m4srvp	130	26	promotes	promote	VBZ
cord-006439-q7m4srvp	130	27	excitatory	excitatory	JJ
cord-006439-q7m4srvp	130	28	activity	activity	NN
cord-006439-q7m4srvp	130	29	.	.	.
cord-006439-q7m4srvp	131	1	Ablation	ablation	NN
cord-006439-q7m4srvp	131	2	of	of	IN
cord-006439-q7m4srvp	131	3	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	131	4	in	in	IN
cord-006439-q7m4srvp	131	5	the	the	DT
cord-006439-q7m4srvp	131	6	PVN	PVN	NNP
cord-006439-q7m4srvp	131	7	blunts	blunt	NNS
cord-006439-q7m4srvp	131	8	pressor	pressor	NN
cord-006439-q7m4srvp	131	9	responses	response	NNS
cord-006439-q7m4srvp	131	10	to	to	IN
cord-006439-q7m4srvp	131	11	acute	acute	JJ
cord-006439-q7m4srvp	131	12	PVN	PVN	NNP
cord-006439-q7m4srvp	131	13	-	-	HYPH
cord-006439-q7m4srvp	131	14	targeted	target	VBN
cord-006439-q7m4srvp	131	15	microinjection	microinjection	NN
cord-006439-q7m4srvp	131	16	of	of	IN
cord-006439-q7m4srvp	131	17	ANG	ANG	NNP
cord-006439-q7m4srvp	131	18	-	-	HYPH
cord-006439-q7m4srvp	131	19	II	II	NNP
cord-006439-q7m4srvp	131	20	.	.	.
cord-006439-q7m4srvp	132	1	This	this	DT
cord-006439-q7m4srvp	132	2	accumulating	accumulate	VBG
cord-006439-q7m4srvp	132	3	evidence	evidence	NN
cord-006439-q7m4srvp	132	4	suggests	suggest	VBZ
cord-006439-q7m4srvp	132	5	the	the	DT
cord-006439-q7m4srvp	132	6	importance	importance	NN
cord-006439-q7m4srvp	132	7	of	of	IN
cord-006439-q7m4srvp	132	8	the	the	DT
cord-006439-q7m4srvp	132	9	opposing	oppose	VBG
cord-006439-q7m4srvp	132	10	roles	role	NNS
cord-006439-q7m4srvp	132	11	of	of	IN
cord-006439-q7m4srvp	132	12	ACE2	ACE2	NNP
cord-006439-q7m4srvp	132	13	and	and	CC
cord-006439-q7m4srvp	132	14	ADAM17	adam17	NN
cord-006439-q7m4srvp	132	15	in	in	IN
cord-006439-q7m4srvp	132	16	modulating	modulate	VBG
cord-006439-q7m4srvp	132	17	of	of	IN
cord-006439-q7m4srvp	132	18	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	132	19	activity	activity	NN
cord-006439-q7m4srvp	132	20	and	and	CC
cord-006439-q7m4srvp	132	21	central	central	JJ
cord-006439-q7m4srvp	132	22	control	control	NN
cord-006439-q7m4srvp	132	23	of	of	IN
cord-006439-q7m4srvp	132	24	blood	blood	NN
cord-006439-q7m4srvp	132	25	pressure	pressure	NN
cord-006439-q7m4srvp	132	26	.	.	.
cord-006439-q7m4srvp	133	1	Finally	finally	RB
cord-006439-q7m4srvp	133	2	,	,	,
cord-006439-q7m4srvp	133	3	it	-PRON-	PRP
cord-006439-q7m4srvp	133	4	has	have	VBZ
cord-006439-q7m4srvp	133	5	been	be	VBN
cord-006439-q7m4srvp	133	6	recognized	recognize	VBN
cord-006439-q7m4srvp	133	7	that	that	IN
cord-006439-q7m4srvp	133	8	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	133	9	has	have	VBZ
cord-006439-q7m4srvp	133	10	a	a	DT
cord-006439-q7m4srvp	133	11	role	role	NN
cord-006439-q7m4srvp	133	12	in	in	IN
cord-006439-q7m4srvp	133	13	processing	process	VBG
cord-006439-q7m4srvp	133	14	the	the	DT
cord-006439-q7m4srvp	133	15	proinflammatory	proinflammatory	JJ
cord-006439-q7m4srvp	133	16	cytokine	cytokine	NN
cord-006439-q7m4srvp	133	17	,	,	,
cord-006439-q7m4srvp	133	18	tumor	tumor	NN
cord-006439-q7m4srvp	133	19	necrosis	necrosis	NN
cord-006439-q7m4srvp	133	20	factor	factor	NN
cord-006439-q7m4srvp	133	21	alpha	alpha	NN
cord-006439-q7m4srvp	133	22	(	(	-LRB-
cord-006439-q7m4srvp	133	23	TNF	TNF	NNP
cord-006439-q7m4srvp	133	24	-	-	HYPH
cord-006439-q7m4srvp	133	25	α	α	NNP
cord-006439-q7m4srvp	133	26	)	)	-RRB-
cord-006439-q7m4srvp	133	27	.	.	.
cord-006439-q7m4srvp	134	1	Indeed	indeed	RB
cord-006439-q7m4srvp	134	2	,	,	,
cord-006439-q7m4srvp	134	3	upregulation	upregulation	NN
cord-006439-q7m4srvp	134	4	of	of	IN
cord-006439-q7m4srvp	134	5	the	the	DT
cord-006439-q7m4srvp	134	6	brain	brain	NN
cord-006439-q7m4srvp	134	7	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	134	8	was	be	VBD
cord-006439-q7m4srvp	134	9	associated	associate	VBN
cord-006439-q7m4srvp	134	10	with	with	IN
cord-006439-q7m4srvp	134	11	elevated	elevated	JJ
cord-006439-q7m4srvp	134	12	TNF	TNF	NNP
cord-006439-q7m4srvp	134	13	-	-	HYPH
cord-006439-q7m4srvp	134	14	α	α	NNP
cord-006439-q7m4srvp	134	15	implicating	implicate	VBG
cord-006439-q7m4srvp	134	16	that	that	DT
cord-006439-q7m4srvp	134	17	attenuation	attenuation	NN
cord-006439-q7m4srvp	134	18	of	of	IN
cord-006439-q7m4srvp	134	19	TNF	TNF	NNP
cord-006439-q7m4srvp	134	20	-	-	HYPH
cord-006439-q7m4srvp	134	21	α	α	NN
cord-006439-q7m4srvp	134	22	-	-	HYPH
cord-006439-q7m4srvp	134	23	related	relate	VBN
cord-006439-q7m4srvp	134	24	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	134	25	could	could	MD
cord-006439-q7m4srvp	134	26	be	be	VB
cord-006439-q7m4srvp	134	27	mediating	mediate	VBG
cord-006439-q7m4srvp	134	28	part	part	NN
cord-006439-q7m4srvp	134	29	of	of	IN
cord-006439-q7m4srvp	134	30	the	the	DT
cord-006439-q7m4srvp	134	31	phenotype	phenotype	NN
cord-006439-q7m4srvp	134	32	observed	observe	VBN
cord-006439-q7m4srvp	134	33	in	in	IN
cord-006439-q7m4srvp	134	34	mice	mouse	NNS
cord-006439-q7m4srvp	134	35	lacking	lack	VBG
cord-006439-q7m4srvp	134	36	hypothalamic	hypothalamic	JJ
cord-006439-q7m4srvp	134	37	ADAM17	adam17	NN
cord-006439-q7m4srvp	134	38	.	.	.
cord-006439-q7m4srvp	135	1	Numerous	numerous	JJ
cord-006439-q7m4srvp	135	2	reports	report	NNS
cord-006439-q7m4srvp	135	3	suggest	suggest	VBP
cord-006439-q7m4srvp	135	4	elevation	elevation	NN
cord-006439-q7m4srvp	135	5	of	of	IN
cord-006439-q7m4srvp	135	6	TNF	TNF	NNP
cord-006439-q7m4srvp	135	7	-	-	HYPH
cord-006439-q7m4srvp	135	8	α	α	NNP
cord-006439-q7m4srvp	135	9	and	and	CC
cord-006439-q7m4srvp	135	10	activation	activation	NN
cord-006439-q7m4srvp	135	11	of	of	IN
cord-006439-q7m4srvp	135	12	inflammatory	inflammatory	JJ
cord-006439-q7m4srvp	135	13	cells	cell	NNS
cord-006439-q7m4srvp	135	14	(	(	-LRB-
cord-006439-q7m4srvp	135	15	microglia	microglia	NNS
cord-006439-q7m4srvp	135	16	)	)	-RRB-
cord-006439-q7m4srvp	135	17	within	within	IN
cord-006439-q7m4srvp	135	18	certain	certain	JJ
cord-006439-q7m4srvp	135	19	brain	brain	NN
cord-006439-q7m4srvp	135	20	regions	region	NNS
cord-006439-q7m4srvp	135	21	triggers	trigger	VBZ
cord-006439-q7m4srvp	135	22	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	135	23	responses	response	NNS
cord-006439-q7m4srvp	135	24	[	[	-LRB-
cord-006439-q7m4srvp	135	25	97	97	CD
cord-006439-q7m4srvp	135	26	]	]	-RRB-
cord-006439-q7m4srvp	135	27	[	[	-LRB-
cord-006439-q7m4srvp	135	28	98	98	CD
cord-006439-q7m4srvp	135	29	]	]	-RRB-
cord-006439-q7m4srvp	135	30	[	[	-LRB-
cord-006439-q7m4srvp	135	31	99	99	CD
cord-006439-q7m4srvp	135	32	]	]	-RRB-
cord-006439-q7m4srvp	135	33	.	.	.
cord-006439-q7m4srvp	136	1	Therefore	therefore	RB
cord-006439-q7m4srvp	136	2	,	,	,
cord-006439-q7m4srvp	136	3	future	future	JJ
cord-006439-q7m4srvp	136	4	studies	study	NNS
cord-006439-q7m4srvp	136	5	are	be	VBP
cord-006439-q7m4srvp	136	6	expected	expect	VBN
cord-006439-q7m4srvp	136	7	to	to	TO
cord-006439-q7m4srvp	136	8	clarify	clarify	VB
cord-006439-q7m4srvp	136	9	whether	whether	IN
cord-006439-q7m4srvp	136	10	TNF	TNF	NNP
cord-006439-q7m4srvp	136	11	-	-	HYPH
cord-006439-q7m4srvp	136	12	α	α	NNP
cord-006439-q7m4srvp	136	13	plays	play	VBZ
cord-006439-q7m4srvp	136	14	a	a	DT
cord-006439-q7m4srvp	136	15	regulatory	regulatory	JJ
cord-006439-q7m4srvp	136	16	role	role	NN
cord-006439-q7m4srvp	136	17	in	in	IN
cord-006439-q7m4srvp	136	18	ACE2	ACE2	NNP
cord-006439-q7m4srvp	136	19	activity	activity	NN
cord-006439-q7m4srvp	136	20	and	and	CC
cord-006439-q7m4srvp	136	21	other	other	JJ
cord-006439-q7m4srvp	136	22	RAS	RAS	NNP
cord-006439-q7m4srvp	136	23	components	component	NNS
cord-006439-q7m4srvp	136	24	.	.	.
cord-006439-q7m4srvp	137	1	A	a	DT
cord-006439-q7m4srvp	137	2	quarter	quarter	NN
cord-006439-q7m4srvp	137	3	of	of	IN
cord-006439-q7m4srvp	137	4	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	137	5	patients	patient	NNS
cord-006439-q7m4srvp	137	6	exhibit	exhibit	VBP
cord-006439-q7m4srvp	137	7	low	low	JJ
cord-006439-q7m4srvp	137	8	-	-	HYPH
cord-006439-q7m4srvp	137	9	renin	renin	NN
cord-006439-q7m4srvp	137	10	hypertension	hypertension	NN
cord-006439-q7m4srvp	137	11	[	[	-LRB-
cord-006439-q7m4srvp	137	12	100	100	CD
cord-006439-q7m4srvp	137	13	]	]	-RRB-
cord-006439-q7m4srvp	137	14	.	.	.
cord-006439-q7m4srvp	138	1	It	-PRON-	PRP
cord-006439-q7m4srvp	138	2	has	have	VBZ
cord-006439-q7m4srvp	138	3	been	be	VBN
cord-006439-q7m4srvp	138	4	suggested	suggest	VBN
cord-006439-q7m4srvp	138	5	that	that	IN
cord-006439-q7m4srvp	138	6	low	low	JJ
cord-006439-q7m4srvp	138	7	-	-	HYPH
cord-006439-q7m4srvp	138	8	renin	renin	NN
cord-006439-q7m4srvp	138	9	hypertension	hypertension	NN
cord-006439-q7m4srvp	138	10	is	be	VBZ
cord-006439-q7m4srvp	138	11	in	in	IN
cord-006439-q7m4srvp	138	12	part	part	NN
cord-006439-q7m4srvp	138	13	driven	drive	VBN
cord-006439-q7m4srvp	138	14	by	by	IN
cord-006439-q7m4srvp	138	15	elevated	elevated	JJ
cord-006439-q7m4srvp	138	16	angiotensinergic	angiotensinergic	NN
cord-006439-q7m4srvp	138	17	signaling	signal	VBG
cord-006439-q7m4srvp	138	18	in	in	IN
cord-006439-q7m4srvp	138	19	the	the	DT
cord-006439-q7m4srvp	138	20	brain	brain	NN
cord-006439-q7m4srvp	138	21	[	[	-LRB-
cord-006439-q7m4srvp	138	22	71	71	CD
cord-006439-q7m4srvp	138	23	,	,	,
cord-006439-q7m4srvp	138	24	101	101	CD
cord-006439-q7m4srvp	138	25	]	]	-RRB-
cord-006439-q7m4srvp	138	26	.	.	.
cord-006439-q7m4srvp	139	1	Therefore	therefore	RB
cord-006439-q7m4srvp	139	2	,	,	,
cord-006439-q7m4srvp	139	3	the	the	DT
cord-006439-q7m4srvp	139	4	development	development	NN
cord-006439-q7m4srvp	139	5	of	of	IN
cord-006439-q7m4srvp	139	6	novel	novel	JJ
cord-006439-q7m4srvp	139	7	drugs	drug	NNS
cord-006439-q7m4srvp	139	8	modulating	modulate	VBG
cord-006439-q7m4srvp	139	9	the	the	DT
cord-006439-q7m4srvp	139	10	brain	brain	NN
cord-006439-q7m4srvp	139	11	RAS	RAS	NNP
cord-006439-q7m4srvp	139	12	might	may	MD
cord-006439-q7m4srvp	139	13	represent	represent	VB
cord-006439-q7m4srvp	139	14	an	an	DT
cord-006439-q7m4srvp	139	15	effective	effective	JJ
cord-006439-q7m4srvp	139	16	solution	solution	NN
cord-006439-q7m4srvp	139	17	to	to	TO
cord-006439-q7m4srvp	139	18	treat	treat	VB
cord-006439-q7m4srvp	139	19	resistant	resistant	JJ
cord-006439-q7m4srvp	139	20	hypertension	hypertension	NN
cord-006439-q7m4srvp	139	21	coincident	coincident	JJ
cord-006439-q7m4srvp	139	22	with	with	IN
cord-006439-q7m4srvp	139	23	elevated	elevated	JJ
cord-006439-q7m4srvp	139	24	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	139	25	activity	activity	NN
cord-006439-q7m4srvp	139	26	and	and	CC
cord-006439-q7m4srvp	139	27	suppressed	suppress	VBD
cord-006439-q7m4srvp	139	28	circulating	circulate	VBG
cord-006439-q7m4srvp	139	29	renin	renin	NN
cord-006439-q7m4srvp	139	30	activity	activity	NN
cord-006439-q7m4srvp	139	31	.	.	.
cord-006439-q7m4srvp	140	1	Two	two	CD
cord-006439-q7m4srvp	140	2	decades	decade	NNS
cord-006439-q7m4srvp	140	3	ago	ago	RB
cord-006439-q7m4srvp	140	4	,	,	,
cord-006439-q7m4srvp	140	5	Llorens	Llorens	NNP
cord-006439-q7m4srvp	140	6	-	-	HYPH
cord-006439-q7m4srvp	140	7	Cortes	Cortes	NNP
cord-006439-q7m4srvp	140	8	's	's	POS
cord-006439-q7m4srvp	140	9	laboratory	laboratory	NN
cord-006439-q7m4srvp	140	10	demonstrated	demonstrate	VBD
cord-006439-q7m4srvp	140	11	that	that	IN
cord-006439-q7m4srvp	140	12	the	the	DT
cord-006439-q7m4srvp	140	13	conversion	conversion	NN
cord-006439-q7m4srvp	140	14	of	of	IN
cord-006439-q7m4srvp	140	15	ANG	ANG	NNP
cord-006439-q7m4srvp	140	16	-	-	HYPH
cord-006439-q7m4srvp	140	17	II	II	NNP
cord-006439-q7m4srvp	140	18	into	into	IN
cord-006439-q7m4srvp	140	19	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	140	20	III	III	NNP
cord-006439-q7m4srvp	140	21	(	(	-LRB-
cord-006439-q7m4srvp	140	22	ANG	ANG	NNP
cord-006439-q7m4srvp	140	23	-	-	HYPH
cord-006439-q7m4srvp	140	24	III	III	NNP
cord-006439-q7m4srvp	140	25	)	)	-RRB-
cord-006439-q7m4srvp	140	26	in	in	IN
cord-006439-q7m4srvp	140	27	the	the	DT
cord-006439-q7m4srvp	140	28	brain	brain	NN
cord-006439-q7m4srvp	140	29	is	be	VBZ
cord-006439-q7m4srvp	140	30	catalyzed	catalyze	VBN
cord-006439-q7m4srvp	140	31	by	by	IN
cord-006439-q7m4srvp	140	32	aminopeptidase	aminopeptidase	NN
cord-006439-q7m4srvp	140	33	A	A	NNP
cord-006439-q7m4srvp	140	34	(	(	-LRB-
cord-006439-q7m4srvp	140	35	APA	APA	NNP
cord-006439-q7m4srvp	140	36	)	)	-RRB-
cord-006439-q7m4srvp	140	37	,	,	,
cord-006439-q7m4srvp	140	38	a	a	DT
cord-006439-q7m4srvp	140	39	zinc	zinc	NN
cord-006439-q7m4srvp	140	40	metalloprotease	metalloprotease	NN
cord-006439-q7m4srvp	140	41	[	[	-LRB-
cord-006439-q7m4srvp	140	42	102	102	CD
cord-006439-q7m4srvp	140	43	]	]	-RRB-
cord-006439-q7m4srvp	140	44	.	.	.
cord-006439-q7m4srvp	141	1	Importantly	importantly	RB
cord-006439-q7m4srvp	141	2	,	,	,
cord-006439-q7m4srvp	141	3	ANG	ANG	NNP
cord-006439-q7m4srvp	141	4	-	-	HYPH
cord-006439-q7m4srvp	141	5	III	III	NNP
cord-006439-q7m4srvp	141	6	has	have	VBZ
cord-006439-q7m4srvp	141	7	been	be	VBN
cord-006439-q7m4srvp	141	8	hypothesized	hypothesize	VBN
cord-006439-q7m4srvp	141	9	to	to	TO
cord-006439-q7m4srvp	141	10	be	be	VB
cord-006439-q7m4srvp	141	11	the	the	DT
cord-006439-q7m4srvp	141	12	major	major	JJ
cord-006439-q7m4srvp	141	13	biologically	biologically	RB
cord-006439-q7m4srvp	141	14	active	active	JJ
cord-006439-q7m4srvp	141	15	peptide	peptide	NN
cord-006439-q7m4srvp	141	16	of	of	IN
cord-006439-q7m4srvp	141	17	the	the	DT
cord-006439-q7m4srvp	141	18	brain	brain	NN
cord-006439-q7m4srvp	141	19	RAS	RAS	NNP
cord-006439-q7m4srvp	141	20	.	.	.
cord-006439-q7m4srvp	142	1	This	this	DT
cord-006439-q7m4srvp	142	2	is	be	VBZ
cord-006439-q7m4srvp	142	3	based	base	VBN
cord-006439-q7m4srvp	142	4	on	on	IN
cord-006439-q7m4srvp	142	5	the	the	DT
cord-006439-q7m4srvp	142	6	observation	observation	NN
cord-006439-q7m4srvp	142	7	that	that	IN
cord-006439-q7m4srvp	142	8	inhibition	inhibition	NN
cord-006439-q7m4srvp	142	9	of	of	IN
cord-006439-q7m4srvp	142	10	the	the	DT
cord-006439-q7m4srvp	142	11	brain	brain	NN
cord-006439-q7m4srvp	142	12	APA	APA	NNP
cord-006439-q7m4srvp	142	13	completely	completely	RB
cord-006439-q7m4srvp	142	14	prevents	prevent	VBZ
cord-006439-q7m4srvp	142	15	elevated	elevate	VBN
cord-006439-q7m4srvp	142	16	blood	blood	NN
cord-006439-q7m4srvp	142	17	pressure	pressure	NN
cord-006439-q7m4srvp	142	18	in	in	IN
cord-006439-q7m4srvp	142	19	models	model	NNS
cord-006439-q7m4srvp	142	20	of	of	IN
cord-006439-q7m4srvp	142	21	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	142	22	hypertension	hypertension	NN
cord-006439-q7m4srvp	142	23	with	with	IN
cord-006439-q7m4srvp	142	24	elevated	elevated	JJ
cord-006439-q7m4srvp	142	25	brain	brain	NN
cord-006439-q7m4srvp	142	26	RAS	RAS	NNP
cord-006439-q7m4srvp	142	27	[	[	-LRB-
cord-006439-q7m4srvp	142	28	103	103	CD
cord-006439-q7m4srvp	142	29	]	]	-RRB-
cord-006439-q7m4srvp	142	30	.	.	.
cord-006439-q7m4srvp	143	1	It	-PRON-	PRP
cord-006439-q7m4srvp	143	2	took	take	VBD
cord-006439-q7m4srvp	143	3	years	year	NNS
cord-006439-q7m4srvp	143	4	to	to	TO
cord-006439-q7m4srvp	143	5	translate	translate	VB
cord-006439-q7m4srvp	143	6	the	the	DT
cord-006439-q7m4srvp	143	7	observation	observation	NN
cord-006439-q7m4srvp	143	8	that	that	IN
cord-006439-q7m4srvp	143	9	pharmacological	pharmacological	JJ
cord-006439-q7m4srvp	143	10	inhibition	inhibition	NN
cord-006439-q7m4srvp	143	11	of	of	IN
cord-006439-q7m4srvp	143	12	APA	APA	NNP
cord-006439-q7m4srvp	143	13	can	can	MD
cord-006439-q7m4srvp	143	14	be	be	VB
cord-006439-q7m4srvp	143	15	used	use	VBN
cord-006439-q7m4srvp	143	16	as	as	IN
cord-006439-q7m4srvp	143	17	a	a	DT
cord-006439-q7m4srvp	143	18	therapeutic	therapeutic	JJ
cord-006439-q7m4srvp	143	19	tool	tool	NN
cord-006439-q7m4srvp	143	20	to	to	TO
cord-006439-q7m4srvp	143	21	treat	treat	VB
cord-006439-q7m4srvp	143	22	resistant	resistant	JJ
cord-006439-q7m4srvp	143	23	hypertension	hypertension	NN
cord-006439-q7m4srvp	143	24	in	in	IN
cord-006439-q7m4srvp	143	25	humans	human	NNS
cord-006439-q7m4srvp	143	26	.	.	.
cord-006439-q7m4srvp	144	1	Recently	recently	RB
cord-006439-q7m4srvp	144	2	,	,	,
cord-006439-q7m4srvp	144	3	a	a	DT
cord-006439-q7m4srvp	144	4	new	new	JJ
cord-006439-q7m4srvp	144	5	multicenter	multicenter	NN
cord-006439-q7m4srvp	144	6	,	,	,
cord-006439-q7m4srvp	144	7	open	open	JJ
cord-006439-q7m4srvp	144	8	-	-	HYPH
cord-006439-q7m4srvp	144	9	label	label	NN
cord-006439-q7m4srvp	144	10	,	,	,
cord-006439-q7m4srvp	144	11	phase	phase	NN
cord-006439-q7m4srvp	144	12	II	ii	CD
cord-006439-q7m4srvp	144	13	study	study	NN
cord-006439-q7m4srvp	144	14	was	be	VBD
cord-006439-q7m4srvp	144	15	released	release	VBN
cord-006439-q7m4srvp	144	16	evidencing	evidence	VBG
cord-006439-q7m4srvp	144	17	the	the	DT
cord-006439-q7m4srvp	144	18	efficacy	efficacy	NN
cord-006439-q7m4srvp	144	19	of	of	IN
cord-006439-q7m4srvp	144	20	a	a	DT
cord-006439-q7m4srvp	144	21	brain	brain	NN
cord-006439-q7m4srvp	144	22	penetrating	penetrate	VBG
cord-006439-q7m4srvp	144	23	inhibitor	inhibitor	NN
cord-006439-q7m4srvp	144	24	of	of	IN
cord-006439-q7m4srvp	144	25	APA	APA	NNP
cord-006439-q7m4srvp	144	26	,	,	,
cord-006439-q7m4srvp	144	27	firibastat	firibastat	NNP
cord-006439-q7m4srvp	144	28	(	(	-LRB-
cord-006439-q7m4srvp	144	29	previously	previously	RB
cord-006439-q7m4srvp	144	30	named	name	VBN
cord-006439-q7m4srvp	144	31	RB150	rb150	NN
cord-006439-q7m4srvp	144	32	)	)	-RRB-
cord-006439-q7m4srvp	144	33	,	,	,
cord-006439-q7m4srvp	144	34	in	in	IN
cord-006439-q7m4srvp	144	35	reducing	reduce	VBG
cord-006439-q7m4srvp	144	36	blood	blood	NN
cord-006439-q7m4srvp	144	37	pressure	pressure	NN
cord-006439-q7m4srvp	144	38	in	in	IN
cord-006439-q7m4srvp	144	39	overweight	overweight	JJ
cord-006439-q7m4srvp	144	40	patients	patient	NNS
cord-006439-q7m4srvp	144	41	of	of	IN
cord-006439-q7m4srvp	144	42	multiple	multiple	JJ
cord-006439-q7m4srvp	144	43	ethnic	ethnic	JJ
cord-006439-q7m4srvp	144	44	origins	origin	NNS
cord-006439-q7m4srvp	144	45	without	without	IN
cord-006439-q7m4srvp	144	46	angioedema	angioedema	NN
cord-006439-q7m4srvp	144	47	[	[	-LRB-
cord-006439-q7m4srvp	144	48	104•	104•	CD
cord-006439-q7m4srvp	144	49	]	]	-RRB-
cord-006439-q7m4srvp	144	50	.	.	.
cord-006439-q7m4srvp	145	1	Moreover	moreover	RB
cord-006439-q7m4srvp	145	2	,	,	,
cord-006439-q7m4srvp	145	3	an	an	DT
cord-006439-q7m4srvp	145	4	additional	additional	JJ
cord-006439-q7m4srvp	145	5	pilot	pilot	NN
cord-006439-q7m4srvp	145	6	double	double	RB
cord-006439-q7m4srvp	145	7	-	-	HYPH
cord-006439-q7m4srvp	145	8	blinded	blinded	JJ
cord-006439-q7m4srvp	145	9	randomized	randomized	JJ
cord-006439-q7m4srvp	145	10	placebo	placebo	NN
cord-006439-q7m4srvp	145	11	-	-	HYPH
cord-006439-q7m4srvp	145	12	controlled	control	VBN
cord-006439-q7m4srvp	145	13	study	study	NN
cord-006439-q7m4srvp	145	14	in	in	IN
cord-006439-q7m4srvp	145	15	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	145	16	patients	patient	NNS
cord-006439-q7m4srvp	145	17	demonstrated	demonstrate	VBD
cord-006439-q7m4srvp	145	18	that	that	IN
cord-006439-q7m4srvp	145	19	blood	blood	NN
cord-006439-q7m4srvp	145	20	pressure	pressure	NN
cord-006439-q7m4srvp	145	21	in	in	IN
cord-006439-q7m4srvp	145	22	firibastat	firibastat	RB
cord-006439-q7m4srvp	145	23	-	-	HYPH
cord-006439-q7m4srvp	145	24	treated	treat	VBN
cord-006439-q7m4srvp	145	25	patients	patient	NNS
cord-006439-q7m4srvp	145	26	trended	trend	VBD
cord-006439-q7m4srvp	145	27	to	to	TO
cord-006439-q7m4srvp	145	28	be	be	VB
cord-006439-q7m4srvp	145	29	decreased	decrease	VBN
cord-006439-q7m4srvp	145	30	compared	compare	VBN
cord-006439-q7m4srvp	145	31	to	to	IN
cord-006439-q7m4srvp	145	32	placebo	placebo	NN
cord-006439-q7m4srvp	145	33	controls	control	NNS
cord-006439-q7m4srvp	145	34	without	without	IN
cord-006439-q7m4srvp	145	35	affecting	affect	VBG
cord-006439-q7m4srvp	145	36	systemic	systemic	JJ
cord-006439-q7m4srvp	145	37	RAS	RAS	NNP
cord-006439-q7m4srvp	145	38	activity	activity	NN
cord-006439-q7m4srvp	145	39	[	[	-LRB-
cord-006439-q7m4srvp	145	40	105	105	CD
cord-006439-q7m4srvp	145	41	]	]	-RRB-
cord-006439-q7m4srvp	145	42	.	.	.
cord-006439-q7m4srvp	146	1	Firibastat	Firibastat	NNP
cord-006439-q7m4srvp	146	2	is	be	VBZ
cord-006439-q7m4srvp	146	3	the	the	DT
cord-006439-q7m4srvp	146	4	first	first	JJ
cord-006439-q7m4srvp	146	5	oral	oral	JJ
cord-006439-q7m4srvp	146	6	medication	medication	NN
cord-006439-q7m4srvp	146	7	that	that	WDT
cord-006439-q7m4srvp	146	8	may	may	MD
cord-006439-q7m4srvp	146	9	target	target	VB
cord-006439-q7m4srvp	146	10	the	the	DT
cord-006439-q7m4srvp	146	11	brain	brain	NN
cord-006439-q7m4srvp	146	12	RAS	RAS	NNP
cord-006439-q7m4srvp	146	13	with	with	IN
cord-006439-q7m4srvp	146	14	promising	promising	JJ
cord-006439-q7m4srvp	146	15	clinical	clinical	JJ
cord-006439-q7m4srvp	146	16	application	application	NN
cord-006439-q7m4srvp	146	17	.	.	.
cord-006439-q7m4srvp	147	1	Current	current	JJ
cord-006439-q7m4srvp	147	2	efforts	effort	NNS
cord-006439-q7m4srvp	147	3	in	in	IN
cord-006439-q7m4srvp	147	4	designing	design	VBG
cord-006439-q7m4srvp	147	5	new	new	JJ
cord-006439-q7m4srvp	147	6	brainpenetrating	brainpenetrate	VBG
cord-006439-q7m4srvp	147	7	APA	APA	NNP
cord-006439-q7m4srvp	147	8	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	147	9	led	lead	VBD
cord-006439-q7m4srvp	147	10	to	to	IN
cord-006439-q7m4srvp	147	11	a	a	DT
cord-006439-q7m4srvp	147	12	10-fold	10-fold	JJ
cord-006439-q7m4srvp	147	13	more	more	RBR
cord-006439-q7m4srvp	147	14	potent	potent	JJ
cord-006439-q7m4srvp	147	15	new	new	JJ
cord-006439-q7m4srvp	147	16	prodrug	prodrug	NN
cord-006439-q7m4srvp	147	17	,	,	,
cord-006439-q7m4srvp	148	1	NI956	NI956	NNP
cord-006439-q7m4srvp	148	2	/	/	SYM
cord-006439-q7m4srvp	148	3	QGC006	QGC006	NNP
cord-006439-q7m4srvp	148	4	,	,	,
cord-006439-q7m4srvp	148	5	which	which	WDT
cord-006439-q7m4srvp	148	6	has	have	VBZ
cord-006439-q7m4srvp	148	7	been	be	VBN
cord-006439-q7m4srvp	148	8	shown	show	VBN
cord-006439-q7m4srvp	148	9	to	to	TO
cord-006439-q7m4srvp	148	10	exert	exert	VB
cord-006439-q7m4srvp	148	11	powerful	powerful	JJ
cord-006439-q7m4srvp	148	12	antihypertensive	antihypertensive	JJ
cord-006439-q7m4srvp	148	13	effects	effect	NNS
cord-006439-q7m4srvp	148	14	in	in	IN
cord-006439-q7m4srvp	148	15	rats	rat	NNS
cord-006439-q7m4srvp	148	16	treated	treat	VBN
cord-006439-q7m4srvp	148	17	with	with	IN
cord-006439-q7m4srvp	148	18	DOCA	DOCA	NNP
cord-006439-q7m4srvp	148	19	-	-	HYPH
cord-006439-q7m4srvp	148	20	salt	salt	NN
cord-006439-q7m4srvp	148	21	[	[	-LRB-
cord-006439-q7m4srvp	148	22	106	106	CD
cord-006439-q7m4srvp	148	23	]	]	-RRB-
cord-006439-q7m4srvp	148	24	.	.	.
cord-006439-q7m4srvp	149	1	In	in	IN
cord-006439-q7m4srvp	149	2	recent	recent	JJ
cord-006439-q7m4srvp	149	3	years	year	NNS
cord-006439-q7m4srvp	149	4	,	,	,
cord-006439-q7m4srvp	149	5	multiple	multiple	JJ
cord-006439-q7m4srvp	149	6	pleiotropic	pleiotropic	JJ
cord-006439-q7m4srvp	149	7	roles	role	NNS
cord-006439-q7m4srvp	149	8	of	of	IN
cord-006439-q7m4srvp	149	9	the	the	DT
cord-006439-q7m4srvp	149	10	brain	brain	NN
cord-006439-q7m4srvp	149	11	RAS	RAS	NNP
cord-006439-q7m4srvp	149	12	,	,	,
cord-006439-q7m4srvp	149	13	namely	namely	RB
cord-006439-q7m4srvp	149	14	neuroinflammation	neuroinflammation	NN
cord-006439-q7m4srvp	149	15	,	,	,
cord-006439-q7m4srvp	149	16	autophagy	autophagy	NN
cord-006439-q7m4srvp	149	17	,	,	,
cord-006439-q7m4srvp	149	18	ER	ER	NNP
cord-006439-q7m4srvp	149	19	stress	stress	NN
cord-006439-q7m4srvp	149	20	,	,	,
cord-006439-q7m4srvp	149	21	and	and	CC
cord-006439-q7m4srvp	149	22	mitochondrial	mitochondrial	JJ
cord-006439-q7m4srvp	149	23	dysfunction	dysfunction	NN
cord-006439-q7m4srvp	149	24	,	,	,
cord-006439-q7m4srvp	149	25	have	have	VBP
cord-006439-q7m4srvp	149	26	emerged	emerge	VBN
cord-006439-q7m4srvp	149	27	.	.	.
cord-006439-q7m4srvp	150	1	These	these	DT
cord-006439-q7m4srvp	150	2	findings	finding	NNS
cord-006439-q7m4srvp	150	3	resulted	result	VBD
cord-006439-q7m4srvp	150	4	in	in	IN
cord-006439-q7m4srvp	150	5	considerable	considerable	JJ
cord-006439-q7m4srvp	150	6	advances	advance	NNS
cord-006439-q7m4srvp	150	7	in	in	IN
cord-006439-q7m4srvp	150	8	utilizing	utilize	VBG
cord-006439-q7m4srvp	150	9	brain	brain	NN
cord-006439-q7m4srvp	150	10	RAS	RAS	NNP
cord-006439-q7m4srvp	150	11	blockade	blockade	NN
cord-006439-q7m4srvp	150	12	or	or	CC
cord-006439-q7m4srvp	150	13	RAS	RAS	NNP
cord-006439-q7m4srvp	150	14	modulation	modulation	NN
cord-006439-q7m4srvp	150	15	as	as	IN
cord-006439-q7m4srvp	150	16	a	a	DT
cord-006439-q7m4srvp	150	17	therapeutic	therapeutic	JJ
cord-006439-q7m4srvp	150	18	strategy	strategy	NN
cord-006439-q7m4srvp	150	19	to	to	TO
cord-006439-q7m4srvp	150	20	treat	treat	VB
cord-006439-q7m4srvp	150	21	diseases	disease	NNS
cord-006439-q7m4srvp	150	22	beyond	beyond	IN
cord-006439-q7m4srvp	150	23	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	150	24	hypertension	hypertension	NN
cord-006439-q7m4srvp	150	25	.	.	.
cord-006439-q7m4srvp	151	1	This	this	DT
cord-006439-q7m4srvp	151	2	is	be	VBZ
cord-006439-q7m4srvp	151	3	specifically	specifically	RB
cord-006439-q7m4srvp	151	4	relevant	relevant	JJ
cord-006439-q7m4srvp	151	5	in	in	IN
cord-006439-q7m4srvp	151	6	stroke	stroke	NN
cord-006439-q7m4srvp	151	7	and	and	CC
cord-006439-q7m4srvp	151	8	cerebrovascular	cerebrovascular	JJ
cord-006439-q7m4srvp	151	9	diseases	disease	NNS
cord-006439-q7m4srvp	151	10	,	,	,
cord-006439-q7m4srvp	151	11	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	151	12	's	's	POS
cord-006439-q7m4srvp	151	13	disease	disease	NN
cord-006439-q7m4srvp	151	14	,	,	,
cord-006439-q7m4srvp	151	15	cognitive	cognitive	JJ
cord-006439-q7m4srvp	151	16	dysfunction	dysfunction	NN
cord-006439-q7m4srvp	151	17	,	,	,
cord-006439-q7m4srvp	151	18	Parkinson	Parkinson	NNP
cord-006439-q7m4srvp	151	19	disease	disease	NN
cord-006439-q7m4srvp	151	20	,	,	,
cord-006439-q7m4srvp	151	21	aging	age	VBG
cord-006439-q7m4srvp	151	22	,	,	,
cord-006439-q7m4srvp	151	23	and	and	CC
cord-006439-q7m4srvp	151	24	others	other	NNS
cord-006439-q7m4srvp	151	25	[	[	-LRB-
cord-006439-q7m4srvp	151	26	107	107	CD
cord-006439-q7m4srvp	151	27	]	]	-RRB-
cord-006439-q7m4srvp	152	1	[	[	-LRB-
cord-006439-q7m4srvp	152	2	108	108	CD
cord-006439-q7m4srvp	152	3	]	]	-RRB-
cord-006439-q7m4srvp	152	4	[	[	-LRB-
cord-006439-q7m4srvp	152	5	109	109	CD
cord-006439-q7m4srvp	152	6	]	]	-RRB-
cord-006439-q7m4srvp	152	7	[	[	-LRB-
cord-006439-q7m4srvp	152	8	110	110	CD
cord-006439-q7m4srvp	152	9	]	]	-RRB-
cord-006439-q7m4srvp	152	10	[	[	-LRB-
cord-006439-q7m4srvp	152	11	111	111	CD
cord-006439-q7m4srvp	152	12	]	]	-RRB-
cord-006439-q7m4srvp	152	13	[	[	-LRB-
cord-006439-q7m4srvp	152	14	112	112	CD
cord-006439-q7m4srvp	152	15	]	]	-RRB-
cord-006439-q7m4srvp	152	16	[	[	-LRB-
cord-006439-q7m4srvp	152	17	113	113	CD
cord-006439-q7m4srvp	152	18	]	]	-RRB-
cord-006439-q7m4srvp	152	19	[	[	-LRB-
cord-006439-q7m4srvp	152	20	114	114	CD
cord-006439-q7m4srvp	152	21	]	]	-RRB-
cord-006439-q7m4srvp	152	22	[	[	-LRB-
cord-006439-q7m4srvp	152	23	115	115	CD
cord-006439-q7m4srvp	152	24	]	]	-RRB-
cord-006439-q7m4srvp	152	25	.	.	.
cord-006439-q7m4srvp	153	1	Numerous	numerous	JJ
cord-006439-q7m4srvp	153	2	other	other	JJ
cord-006439-q7m4srvp	153	3	new	new	JJ
cord-006439-q7m4srvp	153	4	molecules	molecule	NNS
cord-006439-q7m4srvp	153	5	or	or	CC
cord-006439-q7m4srvp	153	6	administration	administration	NN
cord-006439-q7m4srvp	153	7	routes	route	NNS
cord-006439-q7m4srvp	153	8	to	to	TO
cord-006439-q7m4srvp	153	9	target	target	VB
cord-006439-q7m4srvp	153	10	the	the	DT
cord-006439-q7m4srvp	153	11	brain	brain	NN
cord-006439-q7m4srvp	153	12	RAS	RAS	NNP
cord-006439-q7m4srvp	153	13	are	be	VBP
cord-006439-q7m4srvp	153	14	currently	currently	RB
cord-006439-q7m4srvp	153	15	under	under	IN
cord-006439-q7m4srvp	153	16	investigation	investigation	NN
cord-006439-q7m4srvp	153	17	.	.	.
cord-006439-q7m4srvp	154	1	For	for	IN
cord-006439-q7m4srvp	154	2	instance	instance	NN
cord-006439-q7m4srvp	154	3	,	,	,
cord-006439-q7m4srvp	154	4	new	new	JJ
cord-006439-q7m4srvp	154	5	classes	class	NNS
cord-006439-q7m4srvp	154	6	of	of	IN
cord-006439-q7m4srvp	154	7	AT	AT	NNP
cord-006439-q7m4srvp	154	8	1	1	CD
cord-006439-q7m4srvp	154	9	R	r	NN
cord-006439-q7m4srvp	154	10	biased	bias	VBN
cord-006439-q7m4srvp	154	11	agonists	agonist	NNS
cord-006439-q7m4srvp	154	12	,	,	,
cord-006439-q7m4srvp	154	13	which	which	WDT
cord-006439-q7m4srvp	154	14	can	can	MD
cord-006439-q7m4srvp	154	15	selectively	selectively	RB
cord-006439-q7m4srvp	154	16	activate	activate	VB
cord-006439-q7m4srvp	154	17	β	β	NN
cord-006439-q7m4srvp	154	18	-	-	HYPH
cord-006439-q7m4srvp	154	19	arrestin	arrestin	NNP
cord-006439-q7m4srvp	154	20	without	without	IN
cord-006439-q7m4srvp	154	21	activating	activate	VBG
cord-006439-q7m4srvp	154	22	the	the	DT
cord-006439-q7m4srvp	154	23	classical	classical	JJ
cord-006439-q7m4srvp	154	24	G	g	NN
cord-006439-q7m4srvp	154	25	protein	protein	NN
cord-006439-q7m4srvp	154	26	-	-	HYPH
cord-006439-q7m4srvp	154	27	coupled	couple	VBN
cord-006439-q7m4srvp	154	28	signaling	signaling	NN
cord-006439-q7m4srvp	154	29	,	,	,
cord-006439-q7m4srvp	154	30	might	may	MD
cord-006439-q7m4srvp	154	31	represent	represent	VB
cord-006439-q7m4srvp	154	32	potential	potential	JJ
cord-006439-q7m4srvp	154	33	tools	tool	NNS
cord-006439-q7m4srvp	154	34	to	to	TO
cord-006439-q7m4srvp	154	35	modulate	modulate	VB
cord-006439-q7m4srvp	154	36	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	154	37	signaling	signaling	NN
cord-006439-q7m4srvp	154	38	within	within	IN
cord-006439-q7m4srvp	154	39	the	the	DT
cord-006439-q7m4srvp	154	40	brain	brain	NN
cord-006439-q7m4srvp	154	41	.	.	.
cord-006439-q7m4srvp	155	1	For	for	IN
cord-006439-q7m4srvp	155	2	example	example	NN
cord-006439-q7m4srvp	155	3	,	,	,
cord-006439-q7m4srvp	155	4	Carvalho	Carvalho	NNP
cord-006439-q7m4srvp	155	5	-	-	HYPH
cord-006439-q7m4srvp	155	6	Galvão	Galvão	NNP
cord-006439-q7m4srvp	155	7	et	et	NNP
cord-006439-q7m4srvp	155	8	al	al	NNP
cord-006439-q7m4srvp	155	9	.	.	NNP
cord-006439-q7m4srvp	155	10	demonstrated	demonstrate	VBD
cord-006439-q7m4srvp	155	11	that	that	IN
cord-006439-q7m4srvp	155	12	intracerebroventricular	intracerebroventricular	JJ
cord-006439-q7m4srvp	155	13	infusion	infusion	NN
cord-006439-q7m4srvp	155	14	of	of	IN
cord-006439-q7m4srvp	155	15	TRV027	TRV027	NNP
cord-006439-q7m4srvp	155	16	,	,	,
cord-006439-q7m4srvp	155	17	a	a	DT
cord-006439-q7m4srvp	155	18	β	β	NN
cord-006439-q7m4srvp	155	19	-	-	HYPH
cord-006439-q7m4srvp	155	20	arrestin	arrestin	RB
cord-006439-q7m4srvp	155	21	-	-	HYPH
cord-006439-q7m4srvp	155	22	biased	bias	VBN
cord-006439-q7m4srvp	155	23	AT	at	IN
cord-006439-q7m4srvp	155	24	1	1	CD
cord-006439-q7m4srvp	155	25	R	r	NN
cord-006439-q7m4srvp	155	26	-	-	HYPH
cord-006439-q7m4srvp	155	27	agonist	agonist	NN
cord-006439-q7m4srvp	155	28	effectively	effectively	RB
cord-006439-q7m4srvp	155	29	attenuated	attenuate	VBD
cord-006439-q7m4srvp	155	30	autonomic	autonomic	JJ
cord-006439-q7m4srvp	155	31	dysfunction	dysfunction	NN
cord-006439-q7m4srvp	155	32	and	and	CC
cord-006439-q7m4srvp	155	33	decreased	decrease	VBD
cord-006439-q7m4srvp	155	34	arterial	arterial	JJ
cord-006439-q7m4srvp	155	35	pressure	pressure	NN
cord-006439-q7m4srvp	155	36	in	in	IN
cord-006439-q7m4srvp	155	37	spontaneously	spontaneously	RB
cord-006439-q7m4srvp	155	38	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	155	39	rats	rat	NNS
cord-006439-q7m4srvp	155	40	(	(	-LRB-
cord-006439-q7m4srvp	155	41	SHR	SHR	NNP
cord-006439-q7m4srvp	155	42	)	)	-RRB-
cord-006439-q7m4srvp	155	43	[	[	-LRB-
cord-006439-q7m4srvp	155	44	116	116	CD
cord-006439-q7m4srvp	155	45	]	]	-RRB-
cord-006439-q7m4srvp	155	46	.	.	.
cord-006439-q7m4srvp	156	1	Thus	thus	RB
cord-006439-q7m4srvp	156	2	,	,	,
cord-006439-q7m4srvp	156	3	the	the	DT
cord-006439-q7m4srvp	156	4	development	development	NN
cord-006439-q7m4srvp	156	5	of	of	IN
cord-006439-q7m4srvp	156	6	brain	brain	NN
cord-006439-q7m4srvp	156	7	-	-	HYPH
cord-006439-q7m4srvp	156	8	penetrating	penetrate	VBG
cord-006439-q7m4srvp	156	9	AT	AT	NNP
cord-006439-q7m4srvp	156	10	1	1	CD
cord-006439-q7m4srvp	156	11	R	r	NN
cord-006439-q7m4srvp	156	12	-	-	HYPH
cord-006439-q7m4srvp	156	13	biased	bias	VBN
cord-006439-q7m4srvp	156	14	agonists	agonist	NNS
cord-006439-q7m4srvp	156	15	would	would	MD
cord-006439-q7m4srvp	156	16	be	be	VB
cord-006439-q7m4srvp	156	17	a	a	DT
cord-006439-q7m4srvp	156	18	promising	promising	JJ
cord-006439-q7m4srvp	156	19	strategy	strategy	NN
cord-006439-q7m4srvp	156	20	to	to	TO
cord-006439-q7m4srvp	156	21	treat	treat	VB
cord-006439-q7m4srvp	156	22	resistant	resistant	JJ
cord-006439-q7m4srvp	156	23	hypertension	hypertension	NN
cord-006439-q7m4srvp	156	24	.	.	.
cord-006439-q7m4srvp	157	1	Finally	finally	RB
cord-006439-q7m4srvp	157	2	,	,	,
cord-006439-q7m4srvp	157	3	Torika	Torika	NNP
cord-006439-q7m4srvp	157	4	et	et	FW
cord-006439-q7m4srvp	157	5	al	al	NNP
cord-006439-q7m4srvp	157	6	.	.	NNP
cord-006439-q7m4srvp	157	7	demonstrated	demonstrate	VBD
cord-006439-q7m4srvp	157	8	that	that	IN
cord-006439-q7m4srvp	157	9	intranasal	intranasal	NNP
cord-006439-q7m4srvp	157	10	administration	administration	NN
cord-006439-q7m4srvp	157	11	of	of	IN
cord-006439-q7m4srvp	157	12	telmisartan	telmisartan	NNP
cord-006439-q7m4srvp	157	13	is	be	VBZ
cord-006439-q7m4srvp	157	14	effective	effective	JJ
cord-006439-q7m4srvp	157	15	at	at	IN
cord-006439-q7m4srvp	157	16	reducing	reduce	VBG
cord-006439-q7m4srvp	157	17	brain	brain	NN
cord-006439-q7m4srvp	157	18	inflammation	inflammation	NN
cord-006439-q7m4srvp	157	19	and	and	CC
cord-006439-q7m4srvp	157	20	ameliorating	ameliorate	VBG
cord-006439-q7m4srvp	157	21	the	the	DT
cord-006439-q7m4srvp	157	22	progression	progression	NN
cord-006439-q7m4srvp	157	23	of	of	IN
cord-006439-q7m4srvp	157	24	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	157	25	's	's	POS
cord-006439-q7m4srvp	157	26	disease	disease	NN
cord-006439-q7m4srvp	157	27	in	in	IN
cord-006439-q7m4srvp	157	28	mice	mouse	NNS
cord-006439-q7m4srvp	157	29	indicating	indicate	VBG
cord-006439-q7m4srvp	157	30	that	that	IN
cord-006439-q7m4srvp	157	31	novel	novel	JJ
cord-006439-q7m4srvp	157	32	routes	route	NNS
cord-006439-q7m4srvp	157	33	of	of	IN
cord-006439-q7m4srvp	157	34	administration	administration	NN
cord-006439-q7m4srvp	157	35	can	can	MD
cord-006439-q7m4srvp	157	36	also	also	RB
cord-006439-q7m4srvp	157	37	be	be	VB
cord-006439-q7m4srvp	157	38	employed	employ	VBN
cord-006439-q7m4srvp	157	39	to	to	TO
cord-006439-q7m4srvp	157	40	inhibit	inhibit	VB
cord-006439-q7m4srvp	157	41	the	the	DT
cord-006439-q7m4srvp	157	42	brain	brain	NN
cord-006439-q7m4srvp	157	43	RAS	RAS	NNP
cord-006439-q7m4srvp	157	44	without	without	IN
cord-006439-q7m4srvp	157	45	systemic	systemic	JJ
cord-006439-q7m4srvp	157	46	off	off	RP
cord-006439-q7m4srvp	157	47	targets	target	NNS
cord-006439-q7m4srvp	157	48	effects	effect	NNS
cord-006439-q7m4srvp	157	49	[	[	-LRB-
cord-006439-q7m4srvp	157	50	117	117	CD
cord-006439-q7m4srvp	157	51	]	]	-RRB-
cord-006439-q7m4srvp	157	52	.	.	.
cord-006439-q7m4srvp	158	1	The	the	DT
cord-006439-q7m4srvp	158	2	development	development	NN
cord-006439-q7m4srvp	158	3	of	of	IN
cord-006439-q7m4srvp	158	4	several	several	JJ
cord-006439-q7m4srvp	158	5	cutting	cut	VBG
cord-006439-q7m4srvp	158	6	-	-	HYPH
cord-006439-q7m4srvp	158	7	edge	edge	NN
cord-006439-q7m4srvp	158	8	technologies	technology	NNS
cord-006439-q7m4srvp	158	9	to	to	TO
cord-006439-q7m4srvp	158	10	study	study	VB
cord-006439-q7m4srvp	158	11	the	the	DT
cord-006439-q7m4srvp	158	12	CNS	CNS	NNP
cord-006439-q7m4srvp	158	13	predicts	predict	VBZ
cord-006439-q7m4srvp	158	14	that	that	IN
cord-006439-q7m4srvp	158	15	we	-PRON-	PRP
cord-006439-q7m4srvp	158	16	might	may	MD
cord-006439-q7m4srvp	158	17	witness	witness	VB
cord-006439-q7m4srvp	158	18	a	a	DT
cord-006439-q7m4srvp	158	19	profound	profound	JJ
cord-006439-q7m4srvp	158	20	advance	advance	NN
cord-006439-q7m4srvp	158	21	in	in	IN
cord-006439-q7m4srvp	158	22	this	this	DT
cord-006439-q7m4srvp	158	23	field	field	NN
cord-006439-q7m4srvp	158	24	in	in	IN
cord-006439-q7m4srvp	158	25	the	the	DT
cord-006439-q7m4srvp	158	26	near	near	JJ
cord-006439-q7m4srvp	158	27	future	future	NN
cord-006439-q7m4srvp	158	28	.	.	.
cord-006439-q7m4srvp	159	1	Several	several	JJ
cord-006439-q7m4srvp	159	2	laboratories	laboratory	NNS
cord-006439-q7m4srvp	159	3	are	be	VBP
cord-006439-q7m4srvp	159	4	currently	currently	RB
cord-006439-q7m4srvp	159	5	utilizing	utilize	VBG
cord-006439-q7m4srvp	159	6	novel	novel	NN
cord-006439-q7m4srvp	159	7	in	in	IN
cord-006439-q7m4srvp	159	8	situ	situ	JJ
cord-006439-q7m4srvp	159	9	hybridization	hybridization	NN
cord-006439-q7m4srvp	159	10	techniques	technique	NNS
cord-006439-q7m4srvp	159	11	with	with	IN
cord-006439-q7m4srvp	159	12	significantly	significantly	RB
cord-006439-q7m4srvp	159	13	higher	high	JJR
cord-006439-q7m4srvp	159	14	specificity	specificity	NN
cord-006439-q7m4srvp	159	15	and	and	CC
cord-006439-q7m4srvp	159	16	sensitivity	sensitivity	NN
cord-006439-q7m4srvp	159	17	.	.	.
cord-006439-q7m4srvp	160	1	These	these	DT
cord-006439-q7m4srvp	160	2	are	be	VBP
cord-006439-q7m4srvp	160	3	powerful	powerful	JJ
cord-006439-q7m4srvp	160	4	tools	tool	NNS
cord-006439-q7m4srvp	160	5	to	to	TO
cord-006439-q7m4srvp	160	6	identify	identify	VB
cord-006439-q7m4srvp	160	7	the	the	DT
cord-006439-q7m4srvp	160	8	anatomical	anatomical	JJ
cord-006439-q7m4srvp	160	9	and	and	CC
cord-006439-q7m4srvp	160	10	cellular	cellular	JJ
cord-006439-q7m4srvp	160	11	localization	localization	NN
cord-006439-q7m4srvp	160	12	of	of	IN
cord-006439-q7m4srvp	160	13	cells	cell	NNS
cord-006439-q7m4srvp	160	14	expressing	express	VBG
cord-006439-q7m4srvp	160	15	components	component	NNS
cord-006439-q7m4srvp	160	16	of	of	IN
cord-006439-q7m4srvp	160	17	the	the	DT
cord-006439-q7m4srvp	160	18	RAS	RAS	NNP
cord-006439-q7m4srvp	160	19	within	within	IN
cord-006439-q7m4srvp	160	20	the	the	DT
cord-006439-q7m4srvp	160	21	CNS	CNS	NNP
cord-006439-q7m4srvp	160	22	and	and	CC
cord-006439-q7m4srvp	160	23	to	to	TO
cord-006439-q7m4srvp	160	24	query	query	VB
cord-006439-q7m4srvp	160	25	the	the	DT
cord-006439-q7m4srvp	160	26	molecular	molecular	JJ
cord-006439-q7m4srvp	160	27	and/or	and/or	CC
cord-006439-q7m4srvp	160	28	neural	neural	JJ
cord-006439-q7m4srvp	160	29	significance	significance	NN
cord-006439-q7m4srvp	160	30	of	of	IN
cord-006439-q7m4srvp	160	31	these	these	DT
cord-006439-q7m4srvp	160	32	cells	cell	NNS
cord-006439-q7m4srvp	160	33	by	by	IN
cord-006439-q7m4srvp	160	34	multiplexing	multiplexe	VBG
cord-006439-q7m4srvp	160	35	with	with	IN
cord-006439-q7m4srvp	160	36	different	different	JJ
cord-006439-q7m4srvp	160	37	probes	probe	NNS
cord-006439-q7m4srvp	160	38	.	.	.
cord-006439-q7m4srvp	161	1	We	-PRON-	PRP
cord-006439-q7m4srvp	161	2	used	use	VBD
cord-006439-q7m4srvp	161	3	RNAscope	rnascope	NN
cord-006439-q7m4srvp	161	4	®	®	POS
cord-006439-q7m4srvp	161	5	technology	technology	NN
cord-006439-q7m4srvp	161	6	to	to	TO
cord-006439-q7m4srvp	161	7	confirm	confirm	VB
cord-006439-q7m4srvp	161	8	the	the	DT
cord-006439-q7m4srvp	161	9	abundance	abundance	NN
cord-006439-q7m4srvp	161	10	of	of	IN
cord-006439-q7m4srvp	161	11	AGT	AGT	NNP
cord-006439-q7m4srvp	161	12	and	and	CC
cord-006439-q7m4srvp	161	13	the	the	DT
cord-006439-q7m4srvp	161	14	presence	presence	NN
cord-006439-q7m4srvp	161	15	of	of	IN
cord-006439-q7m4srvp	161	16	AT	AT	NNP
cord-006439-q7m4srvp	161	17	1	1	CD
cord-006439-q7m4srvp	161	18	R	r	NN
cord-006439-q7m4srvp	161	19	and	and	CC
cord-006439-q7m4srvp	161	20	PRR	PRR	NNP
cord-006439-q7m4srvp	161	21	in	in	IN
cord-006439-q7m4srvp	161	22	discrete	discrete	JJ
cord-006439-q7m4srvp	161	23	cells	cell	NNS
cord-006439-q7m4srvp	161	24	within	within	IN
cord-006439-q7m4srvp	161	25	the	the	DT
cord-006439-q7m4srvp	161	26	brain	brain	NN
cord-006439-q7m4srvp	161	27	.	.	.
cord-006439-q7m4srvp	162	1	Using	use	VBG
cord-006439-q7m4srvp	162	2	this	this	DT
cord-006439-q7m4srvp	162	3	same	same	JJ
cord-006439-q7m4srvp	162	4	technique	technique	NN
cord-006439-q7m4srvp	162	5	,	,	,
cord-006439-q7m4srvp	162	6	we	-PRON-	PRP
cord-006439-q7m4srvp	162	7	and	and	CC
cord-006439-q7m4srvp	162	8	others	other	NNS
cord-006439-q7m4srvp	162	9	have	have	VBP
cord-006439-q7m4srvp	162	10	identified	identify	VBN
cord-006439-q7m4srvp	162	11	the	the	DT
cord-006439-q7m4srvp	162	12	distribution	distribution	NN
cord-006439-q7m4srvp	162	13	of	of	IN
cord-006439-q7m4srvp	162	14	RAS	RAS	NNP
cord-006439-q7m4srvp	162	15	genes	gene	NNS
cord-006439-q7m4srvp	162	16	in	in	IN
cord-006439-q7m4srvp	162	17	specific	specific	JJ
cord-006439-q7m4srvp	162	18	NeuN+	NeuN+	NNP
cord-006439-q7m4srvp	162	19	neurons	neuron	NNS
cord-006439-q7m4srvp	162	20	,	,	,
cord-006439-q7m4srvp	162	21	GFAP+	gfap+	NN
cord-006439-q7m4srvp	162	22	astrocytes	astrocyte	NNS
cord-006439-q7m4srvp	162	23	,	,	,
cord-006439-q7m4srvp	162	24	and	and	CC
cord-006439-q7m4srvp	162	25	Iba-1	Iba-1	NNP
cord-006439-q7m4srvp	162	26	+	+	CC
cord-006439-q7m4srvp	162	27	microglia	microglia	NN
cord-006439-q7m4srvp	162	28	cells	cell	NNS
cord-006439-q7m4srvp	162	29	in	in	IN
cord-006439-q7m4srvp	162	30	the	the	DT
cord-006439-q7m4srvp	162	31	SFO	SFO	NNP
cord-006439-q7m4srvp	162	32	,	,	,
cord-006439-q7m4srvp	162	33	PVN	PVN	NNP
cord-006439-q7m4srvp	162	34	,	,	,
cord-006439-q7m4srvp	162	35	ARC	ARC	NNP
cord-006439-q7m4srvp	162	36	,	,	,
cord-006439-q7m4srvp	162	37	and	and	CC
cord-006439-q7m4srvp	162	38	the	the	DT
cord-006439-q7m4srvp	162	39	RVLM	RVLM	NNP
cord-006439-q7m4srvp	162	40	(	(	-LRB-
cord-006439-q7m4srvp	162	41	unpublished	unpublished	JJ
cord-006439-q7m4srvp	162	42	)	)	-RRB-
cord-006439-q7m4srvp	162	43	.	.	.
cord-006439-q7m4srvp	163	1	In	in	IN
cord-006439-q7m4srvp	163	2	addition	addition	NN
cord-006439-q7m4srvp	163	3	,	,	,
cord-006439-q7m4srvp	163	4	the	the	DT
cord-006439-q7m4srvp	163	5	development	development	NN
cord-006439-q7m4srvp	163	6	of	of	IN
cord-006439-q7m4srvp	163	7	an	an	DT
cord-006439-q7m4srvp	163	8	extensive	extensive	JJ
cord-006439-q7m4srvp	163	9	array	array	NN
cord-006439-q7m4srvp	163	10	of	of	IN
cord-006439-q7m4srvp	163	11	transgenic	transgenic	JJ
cord-006439-q7m4srvp	163	12	mice	mouse	NNS
cord-006439-q7m4srvp	163	13	carrying	carry	VBG
cord-006439-q7m4srvp	163	14	conditional	conditional	JJ
cord-006439-q7m4srvp	163	15	alleles	allele	NNS
cord-006439-q7m4srvp	163	16	of	of	IN
cord-006439-q7m4srvp	163	17	RAS	RAS	NNP
cord-006439-q7m4srvp	163	18	genes	gene	NNS
cord-006439-q7m4srvp	163	19	as	as	RB
cord-006439-q7m4srvp	163	20	well	well	RB
cord-006439-q7m4srvp	163	21	as	as	IN
cord-006439-q7m4srvp	163	22	mice	mouse	NNS
cord-006439-q7m4srvp	163	23	expressing	express	VBG
cord-006439-q7m4srvp	163	24	tamoxifen	tamoxifen	NN
cord-006439-q7m4srvp	163	25	-	-	HYPH
cord-006439-q7m4srvp	163	26	inducible	inducible	JJ
cord-006439-q7m4srvp	163	27	and/or	and/or	CC
cord-006439-q7m4srvp	163	28	cell	cell	NN
cord-006439-q7m4srvp	163	29	-	-	HYPH
cord-006439-q7m4srvp	163	30	specific	specific	JJ
cord-006439-q7m4srvp	163	31	CRE	CRE	NNP
cord-006439-q7m4srvp	163	32	recombinase	recombinase	NN
cord-006439-q7m4srvp	163	33	expression	expression	NN
cord-006439-q7m4srvp	163	34	facilitates	facilitate	VBZ
cord-006439-q7m4srvp	163	35	further	further	JJ
cord-006439-q7m4srvp	163	36	exploration	exploration	NN
cord-006439-q7m4srvp	163	37	of	of	IN
cord-006439-q7m4srvp	163	38	novel	novel	NN
cord-006439-q7m4srvp	163	39	molecular	molecular	JJ
cord-006439-q7m4srvp	163	40	and	and	CC
cord-006439-q7m4srvp	163	41	physiological	physiological	JJ
cord-006439-q7m4srvp	163	42	functions	function	NNS
cord-006439-q7m4srvp	163	43	of	of	IN
cord-006439-q7m4srvp	163	44	the	the	DT
cord-006439-q7m4srvp	163	45	RAS	RAS	NNP
cord-006439-q7m4srvp	163	46	within	within	IN
cord-006439-q7m4srvp	163	47	specific	specific	JJ
cord-006439-q7m4srvp	163	48	cell	cell	NN
cord-006439-q7m4srvp	163	49	types	type	NNS
cord-006439-q7m4srvp	163	50	within	within	IN
cord-006439-q7m4srvp	163	51	the	the	DT
cord-006439-q7m4srvp	163	52	brain	brain	NN
cord-006439-q7m4srvp	163	53	.	.	.
cord-006439-q7m4srvp	164	1	Novel	novel	JJ
cord-006439-q7m4srvp	164	2	and	and	CC
cord-006439-q7m4srvp	164	3	previously	previously	RB
cord-006439-q7m4srvp	164	4	generated	generate	VBN
cord-006439-q7m4srvp	164	5	animals	animal	NNS
cord-006439-q7m4srvp	164	6	expressing	express	VBG
cord-006439-q7m4srvp	164	7	CRE	CRE	NNP
cord-006439-q7m4srvp	164	8	recombinase	recombinase	NN
cord-006439-q7m4srvp	164	9	under	under	IN
cord-006439-q7m4srvp	164	10	the	the	DT
cord-006439-q7m4srvp	164	11	control	control	NN
cord-006439-q7m4srvp	164	12	of	of	IN
cord-006439-q7m4srvp	164	13	specific	specific	JJ
cord-006439-q7m4srvp	164	14	promotors	promotor	NNS
cord-006439-q7m4srvp	164	15	including	include	VBG
cord-006439-q7m4srvp	164	16	AT	at	IN
cord-006439-q7m4srvp	164	17	1	1	CD
cord-006439-q7m4srvp	164	18	R	R	NNP
cord-006439-q7m4srvp	164	19	-	-	HYPH
cord-006439-q7m4srvp	164	20	CRE	cre	NN
cord-006439-q7m4srvp	164	21	or	or	CC
cord-006439-q7m4srvp	164	22	Ren1-CRE	ren1-cre	NN
cord-006439-q7m4srvp	164	23	mice	mouse	NNS
cord-006439-q7m4srvp	164	24	,	,	,
cord-006439-q7m4srvp	164	25	which	which	WDT
cord-006439-q7m4srvp	164	26	can	can	MD
cord-006439-q7m4srvp	164	27	be	be	VB
cord-006439-q7m4srvp	164	28	crossed	cross	VBN
cord-006439-q7m4srvp	164	29	with	with	IN
cord-006439-q7m4srvp	164	30	mice	mouse	NNS
cord-006439-q7m4srvp	164	31	expressing	express	VBG
cord-006439-q7m4srvp	164	32	CRE	cre	NN
cord-006439-q7m4srvp	164	33	-	-	HYPH
cord-006439-q7m4srvp	164	34	dependent	dependent	JJ
cord-006439-q7m4srvp	164	35	TdTomato	TdTomato	NNP
cord-006439-q7m4srvp	164	36	(	(	-LRB-
cord-006439-q7m4srvp	164	37	or	or	CC
cord-006439-q7m4srvp	164	38	other	other	JJ
cord-006439-q7m4srvp	164	39	reporter	reporter	NN
cord-006439-q7m4srvp	164	40	genes	gene	NNS
cord-006439-q7m4srvp	164	41	)	)	-RRB-
cord-006439-q7m4srvp	164	42	as	as	RB
cord-006439-q7m4srvp	164	43	well	well	RB
cord-006439-q7m4srvp	164	44	as	as	IN
cord-006439-q7m4srvp	164	45	mice	mouse	NNS
cord-006439-q7m4srvp	164	46	expressing	express	VBG
cord-006439-q7m4srvp	164	47	a	a	DT
cord-006439-q7m4srvp	164	48	fluorescent	fluorescent	JJ
cord-006439-q7m4srvp	164	49	reporter	reporter	NN
cord-006439-q7m4srvp	164	50	gene	gene	NN
cord-006439-q7m4srvp	164	51	under	under	IN
cord-006439-q7m4srvp	164	52	the	the	DT
cord-006439-q7m4srvp	164	53	control	control	NN
cord-006439-q7m4srvp	164	54	of	of	IN
cord-006439-q7m4srvp	164	55	RAS	RAS	NNP
cord-006439-q7m4srvp	164	56	genes	gene	NNS
cord-006439-q7m4srvp	164	57	such	such	JJ
cord-006439-q7m4srvp	164	58	as	as	IN
cord-006439-q7m4srvp	164	59	AT	AT	NNP
cord-006439-q7m4srvp	164	60	2	2	CD
cord-006439-q7m4srvp	164	61	R	r	NN
cord-006439-q7m4srvp	164	62	-	-	HYPH
cord-006439-q7m4srvp	164	63	eGFP	egfp	NN
cord-006439-q7m4srvp	165	1	or	or	CC
cord-006439-q7m4srvp	165	2	AT	AT	NNP
cord-006439-q7m4srvp	165	3	1a	1a	CD
cord-006439-q7m4srvp	165	4	R	R	NNP
cord-006439-q7m4srvp	165	5	-	-	HYPH
cord-006439-q7m4srvp	165	6	EGFP	EGFP	NNP
cord-006439-q7m4srvp	165	7	(	(	-LRB-
cord-006439-q7m4srvp	165	8	NZ44	NZ44	NNP
cord-006439-q7m4srvp	165	9	)	)	-RRB-
cord-006439-q7m4srvp	165	10	,	,	,
cord-006439-q7m4srvp	165	11	allow	allow	VB
cord-006439-q7m4srvp	165	12	fluorescent	fluorescent	JJ
cord-006439-q7m4srvp	165	13	labelling	labelling	NN
cord-006439-q7m4srvp	165	14	of	of	IN
cord-006439-q7m4srvp	165	15	cells	cell	NNS
cord-006439-q7m4srvp	165	16	expressing	express	VBG
cord-006439-q7m4srvp	165	17	RAS	RAS	NNP
cord-006439-q7m4srvp	165	18	genes	gene	NNS
cord-006439-q7m4srvp	165	19	[	[	-LRB-
cord-006439-q7m4srvp	165	20	30	30	CD
cord-006439-q7m4srvp	165	21	,	,	,
cord-006439-q7m4srvp	165	22	31•	31•	CD
cord-006439-q7m4srvp	165	23	,	,	,
cord-006439-q7m4srvp	165	24	118	118	CD
cord-006439-q7m4srvp	165	25	,	,	,
cord-006439-q7m4srvp	165	26	119	119	CD
cord-006439-q7m4srvp	165	27	]	]	-RRB-
cord-006439-q7m4srvp	165	28	.	.	.
cord-006439-q7m4srvp	166	1	Significant	significant	JJ
cord-006439-q7m4srvp	166	2	progress	progress	NN
cord-006439-q7m4srvp	166	3	has	have	VBZ
cord-006439-q7m4srvp	166	4	been	be	VBN
cord-006439-q7m4srvp	166	5	made	make	VBN
cord-006439-q7m4srvp	166	6	in	in	IN
cord-006439-q7m4srvp	166	7	developing	develop	VBG
cord-006439-q7m4srvp	166	8	techniques	technique	NNS
cord-006439-q7m4srvp	166	9	to	to	TO
cord-006439-q7m4srvp	166	10	identify	identify	VB
cord-006439-q7m4srvp	166	11	the	the	DT
cord-006439-q7m4srvp	166	12	distinct	distinct	JJ
cord-006439-q7m4srvp	166	13	roles	role	NNS
cord-006439-q7m4srvp	166	14	of	of	IN
cord-006439-q7m4srvp	166	15	specific	specific	JJ
cord-006439-q7m4srvp	166	16	neurons	neuron	NNS
cord-006439-q7m4srvp	166	17	in	in	IN
cord-006439-q7m4srvp	166	18	the	the	DT
cord-006439-q7m4srvp	166	19	brain	brain	NN
cord-006439-q7m4srvp	166	20	.	.	.
cord-006439-q7m4srvp	167	1	These	these	DT
cord-006439-q7m4srvp	167	2	techniques	technique	NNS
cord-006439-q7m4srvp	167	3	include	include	VBP
cord-006439-q7m4srvp	167	4	optogenetics	optogenetic	NNS
cord-006439-q7m4srvp	167	5	and	and	CC
cord-006439-q7m4srvp	167	6	Designer	designer	NN
cord-006439-q7m4srvp	167	7	Receptors	receptor	NNS
cord-006439-q7m4srvp	167	8	Exclusively	exclusively	RB
cord-006439-q7m4srvp	167	9	Activated	activate	VBN
cord-006439-q7m4srvp	167	10	by	by	IN
cord-006439-q7m4srvp	167	11	Designer	designer	NN
cord-006439-q7m4srvp	167	12	Drugs	drug	NNS
cord-006439-q7m4srvp	167	13	(	(	-LRB-
cord-006439-q7m4srvp	167	14	DREADD	DREADD	NNP
cord-006439-q7m4srvp	167	15	)	)	-RRB-
cord-006439-q7m4srvp	167	16	,	,	,
cord-006439-q7m4srvp	167	17	a	a	DT
cord-006439-q7m4srvp	167	18	chemogenetic	chemogenetic	JJ
cord-006439-q7m4srvp	167	19	technique	technique	NN
cord-006439-q7m4srvp	167	20	,	,	,
cord-006439-q7m4srvp	167	21	in	in	IN
cord-006439-q7m4srvp	167	22	which	which	WDT
cord-006439-q7m4srvp	167	23	neuronal	neuronal	JJ
cord-006439-q7m4srvp	167	24	activity	activity	NN
cord-006439-q7m4srvp	167	25	can	can	MD
cord-006439-q7m4srvp	167	26	be	be	VB
cord-006439-q7m4srvp	167	27	stimulated	stimulate	VBN
cord-006439-q7m4srvp	167	28	or	or	CC
cord-006439-q7m4srvp	167	29	suppressed	suppress	VBN
cord-006439-q7m4srvp	167	30	in	in	IN
cord-006439-q7m4srvp	167	31	specific	specific	JJ
cord-006439-q7m4srvp	167	32	brain	brain	NN
cord-006439-q7m4srvp	167	33	nuclei	nucleus	NNS
cord-006439-q7m4srvp	167	34	utilizing	utilize	VBG
cord-006439-q7m4srvp	167	35	light	light	NN
cord-006439-q7m4srvp	167	36	or	or	CC
cord-006439-q7m4srvp	167	37	designer	designer	NN
cord-006439-q7m4srvp	167	38	drugs	drug	NNS
cord-006439-q7m4srvp	167	39	,	,	,
cord-006439-q7m4srvp	167	40	respectively	respectively	RB
cord-006439-q7m4srvp	167	41	.	.	.
cord-006439-q7m4srvp	168	1	Using	use	VBG
cord-006439-q7m4srvp	168	2	these	these	DT
cord-006439-q7m4srvp	168	3	techniques	technique	NNS
cord-006439-q7m4srvp	168	4	,	,	,
cord-006439-q7m4srvp	168	5	several	several	JJ
cord-006439-q7m4srvp	168	6	laboratories	laboratory	NNS
cord-006439-q7m4srvp	168	7	recently	recently	RB
cord-006439-q7m4srvp	168	8	showed	show	VBD
cord-006439-q7m4srvp	168	9	the	the	DT
cord-006439-q7m4srvp	168	10	distinct	distinct	JJ
cord-006439-q7m4srvp	168	11	roles	role	NNS
cord-006439-q7m4srvp	168	12	of	of	IN
cord-006439-q7m4srvp	168	13	specific	specific	JJ
cord-006439-q7m4srvp	168	14	cells	cell	NNS
cord-006439-q7m4srvp	168	15	within	within	IN
cord-006439-q7m4srvp	168	16	selected	select	VBN
cord-006439-q7m4srvp	168	17	nuclei	nucleus	NNS
cord-006439-q7m4srvp	168	18	controlling	control	VBG
cord-006439-q7m4srvp	168	19	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	168	20	,	,	,
cord-006439-q7m4srvp	168	21	metabolic	metabolic	JJ
cord-006439-q7m4srvp	168	22	,	,	,
cord-006439-q7m4srvp	168	23	and	and	CC
cord-006439-q7m4srvp	168	24	autonomic	autonomic	JJ
cord-006439-q7m4srvp	168	25	function	function	NN
cord-006439-q7m4srvp	168	26	.	.	.
cord-006439-q7m4srvp	169	1	For	for	IN
cord-006439-q7m4srvp	169	2	instance	instance	NN
cord-006439-q7m4srvp	169	3	,	,	,
cord-006439-q7m4srvp	169	4	De	De	NNP
cord-006439-q7m4srvp	169	5	Kloet	Kloet	NNP
cord-006439-q7m4srvp	169	6	el	el	NNP
cord-006439-q7m4srvp	169	7	al	al	NNP
cord-006439-q7m4srvp	169	8	.	.	.
cord-006439-q7m4srvp	170	1	recently	recently	RB
cord-006439-q7m4srvp	170	2	reported	report	VBD
cord-006439-q7m4srvp	170	3	that	that	IN
cord-006439-q7m4srvp	170	4	optogenetic	optogenetic	JJ
cord-006439-q7m4srvp	170	5	stimulation	stimulation	NN
cord-006439-q7m4srvp	170	6	of	of	IN
cord-006439-q7m4srvp	170	7	AT	at	NN
cord-006439-q7m4srvp	170	8	1	1	CD
cord-006439-q7m4srvp	170	9	R	r	NN
cord-006439-q7m4srvp	170	10	expressing	express	VBG
cord-006439-q7m4srvp	170	11	neurons	neuron	NNS
cord-006439-q7m4srvp	170	12	in	in	IN
cord-006439-q7m4srvp	170	13	the	the	DT
cord-006439-q7m4srvp	170	14	PVN	PVN	NNP
cord-006439-q7m4srvp	170	15	promotes	promote	VBZ
cord-006439-q7m4srvp	170	16	blood	blood	NN
cord-006439-q7m4srvp	170	17	pressure	pressure	NN
cord-006439-q7m4srvp	170	18	elevation	elevation	NN
cord-006439-q7m4srvp	170	19	and	and	CC
cord-006439-q7m4srvp	170	20	activation	activation	NN
cord-006439-q7m4srvp	170	21	of	of	IN
cord-006439-q7m4srvp	170	22	the	the	DT
cord-006439-q7m4srvp	170	23	hypothalamic	hypothalamic	JJ
cord-006439-q7m4srvp	170	24	-	-	HYPH
cord-006439-q7m4srvp	170	25	pituitary	pituitary	NN
cord-006439-q7m4srvp	170	26	-	-	HYPH
cord-006439-q7m4srvp	170	27	adrenal	adrenal	NN
cord-006439-q7m4srvp	170	28	axis	axis	NN
cord-006439-q7m4srvp	170	29	[	[	-LRB-
cord-006439-q7m4srvp	170	30	31•	31•	CD
cord-006439-q7m4srvp	170	31	]	]	-RRB-
cord-006439-q7m4srvp	170	32	.	.	.
cord-006439-q7m4srvp	171	1	Similarly	similarly	RB
cord-006439-q7m4srvp	171	2	,	,	,
cord-006439-q7m4srvp	171	3	Nation	Nation	NNP
cord-006439-q7m4srvp	171	4	et	et	NNP
cord-006439-q7m4srvp	171	5	al	al	NNP
cord-006439-q7m4srvp	171	6	.	.	NNP
cord-006439-q7m4srvp	171	7	utilized	utilize	VBN
cord-006439-q7m4srvp	171	8	DREADDs	dreadd	NNS
cord-006439-q7m4srvp	171	9	to	to	TO
cord-006439-q7m4srvp	171	10	study	study	VB
cord-006439-q7m4srvp	171	11	the	the	DT
cord-006439-q7m4srvp	171	12	role	role	NN
cord-006439-q7m4srvp	171	13	of	of	IN
cord-006439-q7m4srvp	171	14	SFO	SFO	NNP
cord-006439-q7m4srvp	171	15	neurons	neuron	NNS
cord-006439-q7m4srvp	171	16	in	in	IN
cord-006439-q7m4srvp	171	17	thirst	thirst	NN
cord-006439-q7m4srvp	171	18	and	and	CC
cord-006439-q7m4srvp	171	19	salt	salt	NN
cord-006439-q7m4srvp	171	20	appetite	appetite	NN
cord-006439-q7m4srvp	171	21	[	[	-LRB-
cord-006439-q7m4srvp	171	22	120•	120•	CD
cord-006439-q7m4srvp	171	23	]	]	-RRB-
cord-006439-q7m4srvp	171	24	.	.	.
cord-006439-q7m4srvp	172	1	Stimulation	stimulation	NN
cord-006439-q7m4srvp	172	2	of	of	IN
cord-006439-q7m4srvp	172	3	neuronal	neuronal	JJ
cord-006439-q7m4srvp	172	4	firing	firing	NN
cord-006439-q7m4srvp	172	5	and	and	CC
cord-006439-q7m4srvp	172	6	activation	activation	NN
cord-006439-q7m4srvp	172	7	of	of	IN
cord-006439-q7m4srvp	172	8	Gq	Gq	NNP
cord-006439-q7m4srvp	172	9	signaling	signal	VBG
cord-006439-q7m4srvp	172	10	in	in	IN
cord-006439-q7m4srvp	172	11	mice	mouse	NNS
cord-006439-q7m4srvp	172	12	receiving	receive	VBG
cord-006439-q7m4srvp	172	13	SFO	SFO	NNP
cord-006439-q7m4srvp	172	14	-	-	HYPH
cord-006439-q7m4srvp	172	15	targeted	target	VBN
cord-006439-q7m4srvp	172	16	microinjection	microinjection	NN
cord-006439-q7m4srvp	172	17	of	of	IN
cord-006439-q7m4srvp	172	18	a	a	DT
cord-006439-q7m4srvp	172	19	virus	virus	NN
cord-006439-q7m4srvp	172	20	(	(	-LRB-
cord-006439-q7m4srvp	172	21	AAV2-CaMKII	aav2-camkii	NN
cord-006439-q7m4srvp	172	22	-	-	HYPH
cord-006439-q7m4srvp	172	23	HA	HA	NNP
cord-006439-q7m4srvp	172	24	-	-	HYPH
cord-006439-q7m4srvp	172	25	hM3D(Gq)-IRES	hM3D(Gq)-IRES	NNP
cord-006439-q7m4srvp	172	26	-	-	HYPH
cord-006439-q7m4srvp	172	27	mCitrine	mCitrine	NNP
cord-006439-q7m4srvp	172	28	)	)	-RRB-
cord-006439-q7m4srvp	172	29	to	to	TO
cord-006439-q7m4srvp	172	30	induce	induce	VB
cord-006439-q7m4srvp	172	31	selective	selective	JJ
cord-006439-q7m4srvp	172	32	neuronal	neuronal	JJ
cord-006439-q7m4srvp	172	33	expression	expression	NN
cord-006439-q7m4srvp	172	34	of	of	IN
cord-006439-q7m4srvp	172	35	Gαq	Gαq	NNP
cord-006439-q7m4srvp	172	36	via	via	IN
cord-006439-q7m4srvp	172	37	a	a	DT
cord-006439-q7m4srvp	172	38	designer	designer	NN
cord-006439-q7m4srvp	172	39	receptor	receptor	NN
cord-006439-q7m4srvp	172	40	(	(	-LRB-
cord-006439-q7m4srvp	172	41	hM3D	hm3d	ADD
cord-006439-q7m4srvp	172	42	)	)	-RRB-
cord-006439-q7m4srvp	172	43	that	that	WDT
cord-006439-q7m4srvp	172	44	is	be	VBZ
cord-006439-q7m4srvp	172	45	exclusively	exclusively	RB
cord-006439-q7m4srvp	172	46	activated	activate	VBN
cord-006439-q7m4srvp	172	47	by	by	IN
cord-006439-q7m4srvp	172	48	clozapine	clozapine	NNP
cord-006439-q7m4srvp	172	49	N	N	NNP
cord-006439-q7m4srvp	172	50	-	-	HYPH
cord-006439-q7m4srvp	172	51	oxide	oxide	NN
cord-006439-q7m4srvp	172	52	,	,	,
cord-006439-q7m4srvp	172	53	resulted	result	VBD
cord-006439-q7m4srvp	172	54	in	in	IN
cord-006439-q7m4srvp	172	55	strong	strong	JJ
cord-006439-q7m4srvp	172	56	dipsogenic	dipsogenic	JJ
cord-006439-q7m4srvp	172	57	responses	response	NNS
cord-006439-q7m4srvp	172	58	and	and	CC
cord-006439-q7m4srvp	172	59	preference	preference	NN
cord-006439-q7m4srvp	172	60	to	to	IN
cord-006439-q7m4srvp	172	61	0.3	0.3	CD
cord-006439-q7m4srvp	172	62	M	m	CD
cord-006439-q7m4srvp	172	63	saline	saline	NN
cord-006439-q7m4srvp	172	64	.	.	.
cord-006439-q7m4srvp	173	1	The	the	DT
cord-006439-q7m4srvp	173	2	combination	combination	NN
cord-006439-q7m4srvp	173	3	of	of	IN
cord-006439-q7m4srvp	173	4	these	these	DT
cord-006439-q7m4srvp	173	5	novel	novel	JJ
cord-006439-q7m4srvp	173	6	techniques	technique	NNS
cord-006439-q7m4srvp	173	7	with	with	IN
cord-006439-q7m4srvp	173	8	the	the	DT
cord-006439-q7m4srvp	173	9	array	array	NN
cord-006439-q7m4srvp	173	10	of	of	IN
cord-006439-q7m4srvp	173	11	transgenic	transgenic	JJ
cord-006439-q7m4srvp	173	12	mice	mouse	NNS
cord-006439-q7m4srvp	173	13	described	describe	VBN
cord-006439-q7m4srvp	173	14	above	above	RB
cord-006439-q7m4srvp	173	15	are	be	VBP
cord-006439-q7m4srvp	173	16	powerful	powerful	JJ
cord-006439-q7m4srvp	173	17	tools	tool	NNS
cord-006439-q7m4srvp	173	18	to	to	TO
cord-006439-q7m4srvp	173	19	inquire	inquire	VB
cord-006439-q7m4srvp	173	20	the	the	DT
cord-006439-q7m4srvp	173	21	responses	response	NNS
cord-006439-q7m4srvp	173	22	to	to	IN
cord-006439-q7m4srvp	173	23	stimulating	stimulate	VBG
cord-006439-q7m4srvp	173	24	or	or	CC
cord-006439-q7m4srvp	173	25	inactivating	inactivate	VBG
cord-006439-q7m4srvp	173	26	different	different	JJ
cord-006439-q7m4srvp	173	27	neuronal	neuronal	JJ
cord-006439-q7m4srvp	173	28	circuits	circuit	NNS
cord-006439-q7m4srvp	173	29	in	in	IN
cord-006439-q7m4srvp	173	30	the	the	DT
cord-006439-q7m4srvp	173	31	CNS	CNS	NNP
cord-006439-q7m4srvp	173	32	.	.	.
cord-006439-q7m4srvp	174	1	Finally	finally	RB
cord-006439-q7m4srvp	174	2	,	,	,
cord-006439-q7m4srvp	174	3	emerging	emerge	VBG
cord-006439-q7m4srvp	174	4	"	"	``
cord-006439-q7m4srvp	174	5	omics	omic	NNS
cord-006439-q7m4srvp	174	6	"	"	''
cord-006439-q7m4srvp	174	7	techniques	technique	NNS
cord-006439-q7m4srvp	174	8	are	be	VBP
cord-006439-q7m4srvp	174	9	becoming	become	VBG
cord-006439-q7m4srvp	174	10	more	more	RBR
cord-006439-q7m4srvp	174	11	accessible	accessible	JJ
cord-006439-q7m4srvp	174	12	and	and	CC
cord-006439-q7m4srvp	174	13	reliable	reliable	JJ
cord-006439-q7m4srvp	174	14	to	to	TO
cord-006439-q7m4srvp	174	15	study	study	VB
cord-006439-q7m4srvp	174	16	the	the	DT
cord-006439-q7m4srvp	174	17	transcriptome	transcriptome	NN
cord-006439-q7m4srvp	174	18	profile	profile	NN
cord-006439-q7m4srvp	174	19	in	in	IN
cord-006439-q7m4srvp	174	20	different	different	JJ
cord-006439-q7m4srvp	174	21	neuronal	neuronal	JJ
cord-006439-q7m4srvp	174	22	populations	population	NNS
cord-006439-q7m4srvp	174	23	.	.	.
cord-006439-q7m4srvp	175	1	There	there	EX
cord-006439-q7m4srvp	175	2	is	be	VBZ
cord-006439-q7m4srvp	175	3	particular	particular	JJ
cord-006439-q7m4srvp	175	4	interest	interest	NN
cord-006439-q7m4srvp	175	5	in	in	IN
cord-006439-q7m4srvp	175	6	single	single	JJ
cord-006439-q7m4srvp	175	7	-	-	HYPH
cord-006439-q7m4srvp	175	8	cell	cell	NN
cord-006439-q7m4srvp	175	9	and	and	CC
cord-006439-q7m4srvp	175	10	single	single	JJ
cord-006439-q7m4srvp	175	11	-	-	HYPH
cord-006439-q7m4srvp	175	12	nuclear	nuclear	JJ
cord-006439-q7m4srvp	175	13	RNA	RNA	NNP
cord-006439-q7m4srvp	175	14	sequencing	sequencing	NN
cord-006439-q7m4srvp	175	15	technology	technology	NN
cord-006439-q7m4srvp	175	16	to	to	TO
cord-006439-q7m4srvp	175	17	identify	identify	VB
cord-006439-q7m4srvp	175	18	different	different	JJ
cord-006439-q7m4srvp	175	19	clusters	cluster	NNS
cord-006439-q7m4srvp	175	20	expressing	express	VBG
cord-006439-q7m4srvp	175	21	RAS	RAS	NNP
cord-006439-q7m4srvp	175	22	genes	gene	NNS
cord-006439-q7m4srvp	175	23	to	to	TO
cord-006439-q7m4srvp	175	24	evaluate	evaluate	VB
cord-006439-q7m4srvp	175	25	the	the	DT
cord-006439-q7m4srvp	175	26	molecular	molecular	JJ
cord-006439-q7m4srvp	175	27	signature	signature	NN
cord-006439-q7m4srvp	175	28	of	of	IN
cord-006439-q7m4srvp	175	29	cells	cell	NNS
cord-006439-q7m4srvp	175	30	.	.	.
cord-006439-q7m4srvp	176	1	Although	although	IN
cord-006439-q7m4srvp	176	2	studies	study	NNS
cord-006439-q7m4srvp	176	3	utilizing	utilize	VBG
cord-006439-q7m4srvp	176	4	these	these	DT
cord-006439-q7m4srvp	176	5	techniques	technique	NNS
cord-006439-q7m4srvp	176	6	to	to	TO
cord-006439-q7m4srvp	176	7	specifically	specifically	RB
cord-006439-q7m4srvp	176	8	evaluate	evaluate	VB
cord-006439-q7m4srvp	176	9	the	the	DT
cord-006439-q7m4srvp	176	10	brain	brain	NN
cord-006439-q7m4srvp	176	11	RAS	RAS	NNP
cord-006439-q7m4srvp	176	12	are	be	VBP
cord-006439-q7m4srvp	176	13	not	not	RB
cord-006439-q7m4srvp	176	14	yet	yet	RB
cord-006439-q7m4srvp	176	15	available	available	JJ
cord-006439-q7m4srvp	176	16	,	,	,
cord-006439-q7m4srvp	176	17	Sapouckey	Sapouckey	NNP
cord-006439-q7m4srvp	176	18	recently	recently	RB
cord-006439-q7m4srvp	176	19	reported	report	VBD
cord-006439-q7m4srvp	176	20	an	an	DT
cord-006439-q7m4srvp	176	21	in	in	IN
cord-006439-q7m4srvp	176	22	silico	silico	NN
cord-006439-q7m4srvp	176	23	re	re	NN
cord-006439-q7m4srvp	176	24	-	-	NN
cord-006439-q7m4srvp	176	25	analysis	analysis	NN
cord-006439-q7m4srvp	176	26	of	of	IN
cord-006439-q7m4srvp	176	27	hypothalamic	hypothalamic	JJ
cord-006439-q7m4srvp	176	28	single	single	JJ
cord-006439-q7m4srvp	176	29	-	-	HYPH
cord-006439-q7m4srvp	176	30	cell	cell	NN
cord-006439-q7m4srvp	176	31	RNA	rna	NN
cord-006439-q7m4srvp	176	32	sequencing	sequencing	NN
cord-006439-q7m4srvp	176	33	datasets	dataset	NNS
cord-006439-q7m4srvp	176	34	revealing	reveal	VBG
cord-006439-q7m4srvp	176	35	that	that	IN
cord-006439-q7m4srvp	176	36	AT	AT	NNP
cord-006439-q7m4srvp	176	37	1	1	CD
cord-006439-q7m4srvp	176	38	R	r	NN
cord-006439-q7m4srvp	176	39	is	be	VBZ
cord-006439-q7m4srvp	176	40	expressed	express	VBN
cord-006439-q7m4srvp	176	41	in	in	IN
cord-006439-q7m4srvp	176	42	a	a	DT
cord-006439-q7m4srvp	176	43	specific	specific	JJ
cord-006439-q7m4srvp	176	44	cluster	cluster	NN
cord-006439-q7m4srvp	176	45	of	of	IN
cord-006439-q7m4srvp	176	46	neurons	neuron	NNS
cord-006439-q7m4srvp	176	47	expressing	express	VBG
cord-006439-q7m4srvp	176	48	both	both	DT
cord-006439-q7m4srvp	176	49	Agouti	Agouti	NNP
cord-006439-q7m4srvp	176	50	-	-	HYPH
cord-006439-q7m4srvp	176	51	related	relate	VBN
cord-006439-q7m4srvp	176	52	peptide	peptide	NN
cord-006439-q7m4srvp	176	53	(	(	-LRB-
cord-006439-q7m4srvp	176	54	AgRP	AgRP	NNP
cord-006439-q7m4srvp	176	55	)	)	-RRB-
cord-006439-q7m4srvp	176	56	and	and	CC
cord-006439-q7m4srvp	176	57	leptin	leptin	NN
cord-006439-q7m4srvp	176	58	receptors	receptor	NNS
cord-006439-q7m4srvp	176	59	[	[	-LRB-
cord-006439-q7m4srvp	176	60	121•	121•	CD
cord-006439-q7m4srvp	176	61	]	]	-RRB-
cord-006439-q7m4srvp	176	62	.	.	.
cord-006439-q7m4srvp	177	1	This	this	DT
cord-006439-q7m4srvp	177	2	seminal	seminal	JJ
cord-006439-q7m4srvp	177	3	discovery	discovery	NN
cord-006439-q7m4srvp	177	4	may	may	MD
cord-006439-q7m4srvp	177	5	illuminate	illuminate	VB
cord-006439-q7m4srvp	177	6	the	the	DT
cord-006439-q7m4srvp	177	7	underlying	underlie	VBG
cord-006439-q7m4srvp	177	8	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	177	9	by	by	IN
cord-006439-q7m4srvp	177	10	which	which	WDT
cord-006439-q7m4srvp	177	11	the	the	DT
cord-006439-q7m4srvp	177	12	brain	brain	NN
cord-006439-q7m4srvp	177	13	RAS	RAS	NNP
cord-006439-q7m4srvp	177	14	controls	control	VBZ
cord-006439-q7m4srvp	177	15	resting	rest	VBG
cord-006439-q7m4srvp	177	16	metabolic	metabolic	JJ
cord-006439-q7m4srvp	177	17	rate	rate	NN
cord-006439-q7m4srvp	177	18	and	and	CC
cord-006439-q7m4srvp	177	19	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	177	20	activity	activity	NN
cord-006439-q7m4srvp	177	21	in	in	IN
cord-006439-q7m4srvp	177	22	obesity	obesity	NN
cord-006439-q7m4srvp	177	23	-	-	HYPH
cord-006439-q7m4srvp	177	24	related	relate	VBN
cord-006439-q7m4srvp	177	25	hypertension	hypertension	NN
cord-006439-q7m4srvp	177	26	.	.	.
cord-006439-q7m4srvp	178	1	Although	although	IN
cord-006439-q7m4srvp	178	2	the	the	DT
cord-006439-q7m4srvp	178	3	RAS	RAS	NNP
cord-006439-q7m4srvp	178	4	in	in	IN
cord-006439-q7m4srvp	178	5	the	the	DT
cord-006439-q7m4srvp	178	6	brain	brain	NN
cord-006439-q7m4srvp	178	7	has	have	VBZ
cord-006439-q7m4srvp	178	8	been	be	VBN
cord-006439-q7m4srvp	178	9	studied	study	VBN
cord-006439-q7m4srvp	178	10	for	for	IN
cord-006439-q7m4srvp	178	11	decades	decade	NNS
cord-006439-q7m4srvp	178	12	,	,	,
cord-006439-q7m4srvp	178	13	interesting	interesting	JJ
cord-006439-q7m4srvp	178	14	and	and	CC
cord-006439-q7m4srvp	178	15	seminal	seminal	JJ
cord-006439-q7m4srvp	178	16	discoveries	discovery	NNS
cord-006439-q7m4srvp	178	17	continue	continue	VBP
cord-006439-q7m4srvp	178	18	to	to	TO
cord-006439-q7m4srvp	178	19	be	be	VB
cord-006439-q7m4srvp	178	20	made	make	VBN
cord-006439-q7m4srvp	178	21	to	to	IN
cord-006439-q7m4srvp	178	22	this	this	DT
cord-006439-q7m4srvp	178	23	day	day	NN
cord-006439-q7m4srvp	178	24	.	.	.
cord-006439-q7m4srvp	179	1	These	these	DT
cord-006439-q7m4srvp	179	2	include	include	VBP
cord-006439-q7m4srvp	179	3	assessing	assess	VBG
cord-006439-q7m4srvp	179	4	the	the	DT
cord-006439-q7m4srvp	179	5	functional	functional	JJ
cord-006439-q7m4srvp	179	6	significance	significance	NN
cord-006439-q7m4srvp	179	7	of	of	IN
cord-006439-q7m4srvp	179	8	newly	newly	RB
cord-006439-q7m4srvp	179	9	identified	identify	VBN
cord-006439-q7m4srvp	179	10	components	component	NNS
cord-006439-q7m4srvp	179	11	of	of	IN
cord-006439-q7m4srvp	179	12	the	the	DT
cord-006439-q7m4srvp	179	13	RAS	RAS	NNP
cord-006439-q7m4srvp	179	14	(	(	-LRB-
cord-006439-q7m4srvp	179	15	such	such	JJ
cord-006439-q7m4srvp	179	16	as	as	IN
cord-006439-q7m4srvp	179	17	prorenin	prorenin	JJ
cord-006439-q7m4srvp	179	18	receptor	receptor	NN
cord-006439-q7m4srvp	179	19	)	)	-RRB-
cord-006439-q7m4srvp	179	20	,	,	,
cord-006439-q7m4srvp	179	21	the	the	DT
cord-006439-q7m4srvp	179	22	action	action	NN
cord-006439-q7m4srvp	179	23	of	of	IN
cord-006439-q7m4srvp	179	24	unconventional	unconventional	JJ
cord-006439-q7m4srvp	179	25	RAS	RAS	NNP
cord-006439-q7m4srvp	179	26	peptides	peptide	NNS
cord-006439-q7m4srvp	179	27	(	(	-LRB-
cord-006439-q7m4srvp	179	28	such	such	JJ
cord-006439-q7m4srvp	179	29	as	as	IN
cord-006439-q7m4srvp	179	30	ANG	ANG	NNP
cord-006439-q7m4srvp	179	31	III	III	NNP
cord-006439-q7m4srvp	179	32	)	)	-RRB-
cord-006439-q7m4srvp	179	33	,	,	,
cord-006439-q7m4srvp	179	34	enzymes	enzyme	NNS
cord-006439-q7m4srvp	179	35	which	which	WDT
cord-006439-q7m4srvp	179	36	modify	modify	VBP
cord-006439-q7m4srvp	179	37	RAS	RAS	NNP
cord-006439-q7m4srvp	179	38	components	component	NNS
cord-006439-q7m4srvp	179	39	(	(	-LRB-
cord-006439-q7m4srvp	179	40	such	such	JJ
cord-006439-q7m4srvp	179	41	as	as	IN
cord-006439-q7m4srvp	179	42	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	179	43	)	)	-RRB-
cord-006439-q7m4srvp	179	44	,	,	,
cord-006439-q7m4srvp	179	45	and	and	CC
cord-006439-q7m4srvp	179	46	new	new	JJ
cord-006439-q7m4srvp	179	47	therapeutic	therapeutic	JJ
cord-006439-q7m4srvp	179	48	tools	tool	NNS
cord-006439-q7m4srvp	179	49	to	to	TO
cord-006439-q7m4srvp	179	50	combat	combat	VB
cord-006439-q7m4srvp	179	51	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	179	52	hypertension	hypertension	NN
cord-006439-q7m4srvp	179	53	.	.	.
cord-006439-q7m4srvp	180	1	New	new	JJ
cord-006439-q7m4srvp	180	2	technologies	technology	NNS
cord-006439-q7m4srvp	180	3	are	be	VBP
cord-006439-q7m4srvp	180	4	making	make	VBG
cord-006439-q7m4srvp	180	5	it	-PRON-	PRP
cord-006439-q7m4srvp	180	6	easier	easy	JJR
cord-006439-q7m4srvp	180	7	to	to	TO
cord-006439-q7m4srvp	180	8	answer	answer	VB
cord-006439-q7m4srvp	180	9	old	old	JJ
cord-006439-q7m4srvp	180	10	questions	question	NNS
cord-006439-q7m4srvp	180	11	-	-	:
cord-006439-q7m4srvp	180	12	what	what	WP
cord-006439-q7m4srvp	180	13	is	be	VBZ
cord-006439-q7m4srvp	180	14	the	the	DT
cord-006439-q7m4srvp	180	15	localization	localization	NN
cord-006439-q7m4srvp	180	16	of	of	IN
cord-006439-q7m4srvp	180	17	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	180	18	receptors	receptor	NNS
cord-006439-q7m4srvp	180	19	-	-	:
cord-006439-q7m4srvp	180	20	and	and	CC
cord-006439-q7m4srvp	180	21	investigate	investigate	VB
cord-006439-q7m4srvp	180	22	new	new	JJ
cord-006439-q7m4srvp	180	23	ones	one	NNS
cord-006439-q7m4srvp	180	24	-	-	:
cord-006439-q7m4srvp	180	25	what	what	WP
cord-006439-q7m4srvp	180	26	are	be	VBP
cord-006439-q7m4srvp	180	27	function	function	NN
cord-006439-q7m4srvp	180	28	of	of	IN
cord-006439-q7m4srvp	180	29	specific	specific	JJ
cord-006439-q7m4srvp	180	30	subsets	subset	NNS
cord-006439-q7m4srvp	180	31	of	of	IN
cord-006439-q7m4srvp	180	32	AT	at	NN
cord-006439-q7m4srvp	180	33	1	1	CD
cord-006439-q7m4srvp	180	34	R	r	NN
cord-006439-q7m4srvp	180	35	-	-	HYPH
cord-006439-q7m4srvp	180	36	containng	containng	NN
cord-006439-q7m4srvp	180	37	neurons	neuron	NNS
cord-006439-q7m4srvp	180	38	?	?	.
cord-006439-q7m4srvp	181	1	New	new	JJ
cord-006439-q7m4srvp	181	2	genomic	genomic	JJ
cord-006439-q7m4srvp	181	3	technologies	technology	NNS
cord-006439-q7m4srvp	181	4	such	such	JJ
cord-006439-q7m4srvp	181	5	as	as	IN
cord-006439-q7m4srvp	181	6	single	single	JJ
cord-006439-q7m4srvp	181	7	cell	cell	NN
cord-006439-q7m4srvp	181	8	sequencing	sequencing	NN
cord-006439-q7m4srvp	181	9	will	will	MD
cord-006439-q7m4srvp	181	10	provide	provide	VB
cord-006439-q7m4srvp	181	11	novel	novel	JJ
cord-006439-q7m4srvp	181	12	platforms	platform	NNS
cord-006439-q7m4srvp	181	13	to	to	TO
cord-006439-q7m4srvp	181	14	understand	understand	VB
cord-006439-q7m4srvp	181	15	the	the	DT
cord-006439-q7m4srvp	181	16	diversity	diversity	NN
cord-006439-q7m4srvp	181	17	of	of	IN
cord-006439-q7m4srvp	181	18	neuronal	neuronal	JJ
cord-006439-q7m4srvp	181	19	types	type	NNS
cord-006439-q7m4srvp	181	20	which	which	WDT
cord-006439-q7m4srvp	181	21	respond	respond	VBP
cord-006439-q7m4srvp	181	22	to	to	IN
cord-006439-q7m4srvp	181	23	RAS	RAS	NNP
cord-006439-q7m4srvp	181	24	activation	activation	NN
cord-006439-q7m4srvp	181	25	or	or	CC
cord-006439-q7m4srvp	181	26	mediate	mediate	VB
cord-006439-q7m4srvp	181	27	downstream	downstream	JJ
cord-006439-q7m4srvp	181	28	RAS	RAS	NNP
cord-006439-q7m4srvp	181	29	signaling	signaling	NN
cord-006439-q7m4srvp	181	30	.	.	.
cord-006439-q7m4srvp	182	1	Conflict	conflict	NN
cord-006439-q7m4srvp	182	2	of	of	IN
cord-006439-q7m4srvp	182	3	Interest	interest	NN
cord-006439-q7m4srvp	183	1	The	the	DT
cord-006439-q7m4srvp	183	2	authors	author	NNS
cord-006439-q7m4srvp	183	3	declare	declare	VBP
cord-006439-q7m4srvp	183	4	no	no	DT
cord-006439-q7m4srvp	183	5	conflicts	conflict	NNS
cord-006439-q7m4srvp	183	6	of	of	IN
cord-006439-q7m4srvp	183	7	interest	interest	NN
cord-006439-q7m4srvp	183	8	relevant	relevant	JJ
cord-006439-q7m4srvp	183	9	to	to	IN
cord-006439-q7m4srvp	183	10	this	this	DT
cord-006439-q7m4srvp	183	11	manuscript	manuscript	NN
cord-006439-q7m4srvp	183	12	.	.	.
cord-006439-q7m4srvp	184	1	Human	human	JJ
cord-006439-q7m4srvp	184	2	and	and	CC
cord-006439-q7m4srvp	184	3	Animal	Animal	NNP
cord-006439-q7m4srvp	184	4	Rights	Rights	NNPS
cord-006439-q7m4srvp	184	5	and	and	CC
cord-006439-q7m4srvp	184	6	Informed	Informed	NNP
cord-006439-q7m4srvp	184	7	Consent	Consent	NNP
cord-006439-q7m4srvp	185	1	This	this	DT
cord-006439-q7m4srvp	185	2	article	article	NN
cord-006439-q7m4srvp	185	3	does	do	VBZ
cord-006439-q7m4srvp	185	4	not	not	RB
cord-006439-q7m4srvp	185	5	contain	contain	VB
cord-006439-q7m4srvp	185	6	any	any	DT
cord-006439-q7m4srvp	185	7	studies	study	NNS
cord-006439-q7m4srvp	185	8	with	with	IN
cord-006439-q7m4srvp	185	9	human	human	JJ
cord-006439-q7m4srvp	185	10	or	or	CC
cord-006439-q7m4srvp	185	11	animal	animal	NN
cord-006439-q7m4srvp	185	12	subjects	subject	NNS
cord-006439-q7m4srvp	185	13	performed	perform	VBN
cord-006439-q7m4srvp	185	14	by	by	IN
cord-006439-q7m4srvp	185	15	any	any	DT
cord-006439-q7m4srvp	185	16	of	of	IN
cord-006439-q7m4srvp	185	17	the	the	DT
cord-006439-q7m4srvp	185	18	authors	author	NNS
cord-006439-q7m4srvp	185	19	.	.	.
cord-006439-q7m4srvp	186	1	Papers	paper	NNS
cord-006439-q7m4srvp	186	2	of	of	IN
cord-006439-q7m4srvp	186	3	particular	particular	JJ
cord-006439-q7m4srvp	186	4	interest	interest	NN
cord-006439-q7m4srvp	186	5	,	,	,
cord-006439-q7m4srvp	186	6	published	publish	VBN
cord-006439-q7m4srvp	186	7	recently	recently	RB
cord-006439-q7m4srvp	186	8	,	,	,
cord-006439-q7m4srvp	186	9	have	have	VBP
cord-006439-q7m4srvp	186	10	been	be	VBN
cord-006439-q7m4srvp	186	11	highlighted	highlight	VBN
cord-006439-q7m4srvp	186	12	as	as	IN
cord-006439-q7m4srvp	186	13	:	:	:
cord-006439-q7m4srvp	186	14	•	•	.
cord-006439-q7m4srvp	187	1	Of	of	IN
cord-006439-q7m4srvp	187	2	importance	importance	NN
cord-006439-q7m4srvp	187	3	••	••	CD
cord-006439-q7m4srvp	188	1	Of	of	IN
cord-006439-q7m4srvp	188	2	major	major	JJ
cord-006439-q7m4srvp	188	3	importance	importance	NN
cord-006439-q7m4srvp	188	4	Heart	heart	NN
cord-006439-q7m4srvp	188	5	disease	disease	NN
cord-006439-q7m4srvp	188	6	and	and	CC
cord-006439-q7m4srvp	188	7	stroke	stroke	NN
cord-006439-q7m4srvp	188	8	statistics-2015	statistics-2015	NNP
cord-006439-q7m4srvp	188	9	update	update	NN
cord-006439-q7m4srvp	188	10	:	:	:
cord-006439-q7m4srvp	188	11	a	a	DT
cord-006439-q7m4srvp	188	12	report	report	NN
cord-006439-q7m4srvp	188	13	from	from	IN
cord-006439-q7m4srvp	188	14	the	the	DT
cord-006439-q7m4srvp	188	15	Classical	Classical	NNP
cord-006439-q7m4srvp	188	16	renin	renin	NN
cord-006439-q7m4srvp	188	17	-	-	HYPH
cord-006439-q7m4srvp	188	18	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	188	19	system	system	NN
cord-006439-q7m4srvp	188	20	in	in	IN
cord-006439-q7m4srvp	188	21	kidney	kidney	NN
cord-006439-q7m4srvp	188	22	physiology	physiology	NN
cord-006439-q7m4srvp	188	23	Angiotensin-(1	Angiotensin-(1	NNP
cord-006439-q7m4srvp	188	24	-	-	HYPH
cord-006439-q7m4srvp	188	25	7	7	CD
cord-006439-q7m4srvp	188	26	)	)	-RRB-
cord-006439-q7m4srvp	188	27	counterregulates	counterregulates	NNP
cord-006439-q7m4srvp	188	28	angiotensin	angiotensin	NNP
cord-006439-q7m4srvp	188	29	II	II	NNP
cord-006439-q7m4srvp	188	30	signaling	signal	VBG
cord-006439-q7m4srvp	188	31	in	in	IN
cord-006439-q7m4srvp	188	32	human	human	JJ
cord-006439-q7m4srvp	188	33	endothelial	endothelial	JJ
cord-006439-q7m4srvp	188	34	cells	cell	NNS
cord-006439-q7m4srvp	188	35	Discovery	discovery	NN
cord-006439-q7m4srvp	188	36	and	and	CC
cord-006439-q7m4srvp	188	37	characterization	characterization	NN
cord-006439-q7m4srvp	188	38	of	of	IN
cord-006439-q7m4srvp	188	39	alamandine	alamandine	NN
cord-006439-q7m4srvp	188	40	:	:	:
cord-006439-q7m4srvp	188	41	a	a	DT
cord-006439-q7m4srvp	188	42	novel	novel	JJ
cord-006439-q7m4srvp	188	43	component	component	NN
cord-006439-q7m4srvp	188	44	of	of	IN
cord-006439-q7m4srvp	188	45	the	the	DT
cord-006439-q7m4srvp	188	46	renin	renin	NN
cord-006439-q7m4srvp	188	47	-	-	HYPH
cord-006439-q7m4srvp	188	48	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	188	49	system	system	NN
cord-006439-q7m4srvp	189	1	The	the	DT
cord-006439-q7m4srvp	189	2	use	use	NN
cord-006439-q7m4srvp	189	3	of	of	IN
cord-006439-q7m4srvp	189	4	renin	renin	NN
cord-006439-q7m4srvp	189	5	-	-	HYPH
cord-006439-q7m4srvp	189	6	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	189	7	system	system	NN
cord-006439-q7m4srvp	189	8	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	189	9	in	in	IN
cord-006439-q7m4srvp	189	10	patients	patient	NNS
cord-006439-q7m4srvp	189	11	with	with	IN
cord-006439-q7m4srvp	189	12	chronic	chronic	JJ
cord-006439-q7m4srvp	189	13	kidney	kidney	NN
cord-006439-q7m4srvp	189	14	disease	disease	NN
cord-006439-q7m4srvp	189	15	Heart	Heart	NNP
cord-006439-q7m4srvp	189	16	failure	failure	NN
cord-006439-q7m4srvp	189	17	drug	drug	NN
cord-006439-q7m4srvp	189	18	treatment	treatment	NN
cord-006439-q7m4srvp	189	19	Treatment	treatment	NN
cord-006439-q7m4srvp	189	20	of	of	IN
cord-006439-q7m4srvp	189	21	diabetic	diabetic	JJ
cord-006439-q7m4srvp	189	22	nephropathy	nephropathy	NN
cord-006439-q7m4srvp	189	23	with	with	IN
cord-006439-q7m4srvp	189	24	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	189	25	II	II	NNP
cord-006439-q7m4srvp	189	26	receptor	receptor	NN
cord-006439-q7m4srvp	189	27	antagonist	antagonist	NN
cord-006439-q7m4srvp	189	28	Update	update	NN
cord-006439-q7m4srvp	189	29	on	on	IN
cord-006439-q7m4srvp	189	30	clinical	clinical	JJ
cord-006439-q7m4srvp	189	31	trials	trial	NNS
cord-006439-q7m4srvp	189	32	of	of	IN
cord-006439-q7m4srvp	189	33	losartan	losartan	NNP
cord-006439-q7m4srvp	189	34	with	with	IN
cord-006439-q7m4srvp	189	35	and	and	CC
cord-006439-q7m4srvp	189	36	without	without	IN
cord-006439-q7m4srvp	189	37	beta	beta	NN
cord-006439-q7m4srvp	189	38	-	-	HYPH
cord-006439-q7m4srvp	189	39	blockers	blocker	NNS
cord-006439-q7m4srvp	189	40	to	to	TO
cord-006439-q7m4srvp	189	41	block	block	VB
cord-006439-q7m4srvp	189	42	aneurysm	aneurysm	NN
cord-006439-q7m4srvp	189	43	growth	growth	NN
cord-006439-q7m4srvp	189	44	in	in	IN
cord-006439-q7m4srvp	189	45	patients	patient	NNS
cord-006439-q7m4srvp	189	46	with	with	IN
cord-006439-q7m4srvp	189	47	Marfan	Marfan	NNP
cord-006439-q7m4srvp	189	48	syndrome	syndrome	NN
cord-006439-q7m4srvp	189	49	:	:	:
cord-006439-q7m4srvp	189	50	a	a	DT
cord-006439-q7m4srvp	189	51	review	review	NN
cord-006439-q7m4srvp	189	52	Antiproteinuric	Antiproteinuric	NNP
cord-006439-q7m4srvp	189	53	effect	effect	NN
cord-006439-q7m4srvp	189	54	of	of	IN
cord-006439-q7m4srvp	189	55	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	189	56	-	-	HYPH
cord-006439-q7m4srvp	189	57	converting	convert	VBG
cord-006439-q7m4srvp	189	58	enzyme	enzyme	NN
cord-006439-q7m4srvp	189	59	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	189	60	and	and	CC
cord-006439-q7m4srvp	189	61	an	an	DT
cord-006439-q7m4srvp	189	62	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	189	63	II	ii	CD
cord-006439-q7m4srvp	189	64	receptor	receptor	NN
cord-006439-q7m4srvp	189	65	blocker	blocker	NN
cord-006439-q7m4srvp	189	66	in	in	IN
cord-006439-q7m4srvp	189	67	patients	patient	NNS
cord-006439-q7m4srvp	189	68	with	with	IN
cord-006439-q7m4srvp	189	69	lupus	lupus	NN
cord-006439-q7m4srvp	189	70	nephritis	nephritis	NN
cord-006439-q7m4srvp	189	71	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	189	72	II	II	NNP
cord-006439-q7m4srvp	189	73	in	in	IN
cord-006439-q7m4srvp	189	74	inflammation	inflammation	NN
cord-006439-q7m4srvp	189	75	,	,	,
cord-006439-q7m4srvp	189	76	immunity	immunity	NN
cord-006439-q7m4srvp	189	77	and	and	CC
cord-006439-q7m4srvp	189	78	rheumatoid	rheumatoid	NN
cord-006439-q7m4srvp	189	79	arthritis	arthritis	NN
cord-006439-q7m4srvp	189	80	Enalapril	Enalapril	NNP
cord-006439-q7m4srvp	189	81	in	in	IN
cord-006439-q7m4srvp	189	82	lowrenin	lowrenin	JJ
cord-006439-q7m4srvp	189	83	essential	essential	JJ
cord-006439-q7m4srvp	189	84	hypertension	hypertension	NN
cord-006439-q7m4srvp	189	85	Synergistic	synergistic	JJ
cord-006439-q7m4srvp	189	86	effect	effect	NN
cord-006439-q7m4srvp	189	87	of	of	IN
cord-006439-q7m4srvp	189	88	captopril	captopril	NN
cord-006439-q7m4srvp	189	89	with	with	IN
cord-006439-q7m4srvp	189	90	hydrochlorothiazide	hydrochlorothiazide	NN
cord-006439-q7m4srvp	189	91	for	for	IN
cord-006439-q7m4srvp	189	92	the	the	DT
cord-006439-q7m4srvp	189	93	treatment	treatment	NN
cord-006439-q7m4srvp	189	94	of	of	IN
cord-006439-q7m4srvp	189	95	low	low	JJ
cord-006439-q7m4srvp	189	96	-	-	HYPH
cord-006439-q7m4srvp	189	97	renin	renin	NN
cord-006439-q7m4srvp	189	98	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	189	99	black	black	JJ
cord-006439-q7m4srvp	189	100	patients	patient	NNS
cord-006439-q7m4srvp	189	101	Evidence	evidence	NN
cord-006439-q7m4srvp	189	102	for	for	IN
cord-006439-q7m4srvp	189	103	a	a	DT
cord-006439-q7m4srvp	189	104	central	central	JJ
cord-006439-q7m4srvp	189	105	mechanism	mechanism	NN
cord-006439-q7m4srvp	189	106	in	in	IN
cord-006439-q7m4srvp	189	107	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	189	108	induced	induce	VBN
cord-006439-q7m4srvp	189	109	hypertension	hypertension	NN
cord-006439-q7m4srvp	190	1	The	the	DT
cord-006439-q7m4srvp	190	2	brain	brain	NN
cord-006439-q7m4srvp	190	3	renin	renin	NN
cord-006439-q7m4srvp	190	4	-	-	HYPH
cord-006439-q7m4srvp	190	5	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	190	6	system	system	NN
cord-006439-q7m4srvp	190	7	controls	control	VBZ
cord-006439-q7m4srvp	190	8	divergent	divergent	JJ
cord-006439-q7m4srvp	190	9	efferent	efferent	JJ
cord-006439-q7m4srvp	190	10	mechanisms	mechanism	NNS
cord-006439-q7m4srvp	190	11	to	to	TO
cord-006439-q7m4srvp	190	12	regulate	regulate	VB
cord-006439-q7m4srvp	190	13	fluid	fluid	NN
cord-006439-q7m4srvp	190	14	and	and	CC
cord-006439-q7m4srvp	190	15	energy	energy	NN
cord-006439-q7m4srvp	190	16	balance	balance	NN
cord-006439-q7m4srvp	190	17	Increased	increase	VBD
cord-006439-q7m4srvp	190	18	sodium	sodium	NN
cord-006439-q7m4srvp	190	19	appetite	appetite	NN
cord-006439-q7m4srvp	190	20	in	in	IN
cord-006439-q7m4srvp	190	21	the	the	DT
cord-006439-q7m4srvp	190	22	rat	rat	NN
cord-006439-q7m4srvp	190	23	induced	induce	VBN
cord-006439-q7m4srvp	190	24	by	by	IN
cord-006439-q7m4srvp	190	25	intracranial	intracranial	JJ
cord-006439-q7m4srvp	190	26	administration	administration	NN
cord-006439-q7m4srvp	190	27	of	of	IN
cord-006439-q7m4srvp	190	28	components	component	NNS
cord-006439-q7m4srvp	190	29	of	of	IN
cord-006439-q7m4srvp	190	30	the	the	DT
cord-006439-q7m4srvp	190	31	renin	renin	NN
cord-006439-q7m4srvp	190	32	-	-	HYPH
cord-006439-q7m4srvp	190	33	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	190	34	system	system	NN
cord-006439-q7m4srvp	190	35	Interrelationship	Interrelationship	NNP
cord-006439-q7m4srvp	190	36	between	between	IN
cord-006439-q7m4srvp	190	37	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	190	38	II	II	NNP
cord-006439-q7m4srvp	190	39	and	and	CC
cord-006439-q7m4srvp	190	40	the	the	DT
cord-006439-q7m4srvp	190	41	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	190	42	nervous	nervous	JJ
cord-006439-q7m4srvp	190	43	system	system	NN
cord-006439-q7m4srvp	190	44	Differential	differential	JJ
cord-006439-q7m4srvp	190	45	effects	effect	NNS
cord-006439-q7m4srvp	190	46	of	of	IN
cord-006439-q7m4srvp	190	47	central	central	JJ
cord-006439-q7m4srvp	190	48	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	190	49	II	II	NNP
cord-006439-q7m4srvp	190	50	and	and	CC
cord-006439-q7m4srvp	190	51	substance	substance	NN
cord-006439-q7m4srvp	190	52	P	p	NN
cord-006439-q7m4srvp	190	53	on	on	IN
cord-006439-q7m4srvp	190	54	sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	190	55	nerve	nerve	NN
cord-006439-q7m4srvp	190	56	activity	activity	NN
cord-006439-q7m4srvp	190	57	in	in	IN
cord-006439-q7m4srvp	190	58	conscious	conscious	JJ
cord-006439-q7m4srvp	190	59	rats	rat	NNS
cord-006439-q7m4srvp	190	60	.	.	.
cord-006439-q7m4srvp	191	1	Implications	implication	NNS
cord-006439-q7m4srvp	191	2	for	for	IN
cord-006439-q7m4srvp	191	3	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	191	4	adaptation	adaptation	NN
cord-006439-q7m4srvp	191	5	to	to	IN
cord-006439-q7m4srvp	191	6	behavioral	behavioral	JJ
cord-006439-q7m4srvp	191	7	responses	response	NNS
cord-006439-q7m4srvp	191	8	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	191	9	type	type	NN
cord-006439-q7m4srvp	191	10	1a	1a	CD
cord-006439-q7m4srvp	191	11	receptors	receptor	NNS
cord-006439-q7m4srvp	191	12	in	in	IN
cord-006439-q7m4srvp	191	13	the	the	DT
cord-006439-q7m4srvp	191	14	subfornical	subfornical	JJ
cord-006439-q7m4srvp	191	15	organ	organ	NN
cord-006439-q7m4srvp	191	16	are	be	VBP
cord-006439-q7m4srvp	191	17	required	require	VBN
cord-006439-q7m4srvp	191	18	for	for	IN
cord-006439-q7m4srvp	191	19	deoxycorticosterone	deoxycorticosterone	NNP
cord-006439-q7m4srvp	191	20	acetate	acetate	NN
cord-006439-q7m4srvp	191	21	-	-	HYPH
cord-006439-q7m4srvp	191	22	salt	salt	NN
cord-006439-q7m4srvp	191	23	hypertension	hypertension	NN
cord-006439-q7m4srvp	192	1	Angiotensin	angiotensin	NN
cord-006439-q7m4srvp	192	2	AT1A	AT1A	NNP
cord-006439-q7m4srvp	192	3	receptors	receptor	NNS
cord-006439-q7m4srvp	192	4	expressed	express	VBN
cord-006439-q7m4srvp	192	5	in	in	IN
cord-006439-q7m4srvp	192	6	vasopressin	vasopressin	NN
cord-006439-q7m4srvp	192	7	-	-	HYPH
cord-006439-q7m4srvp	192	8	producing	produce	VBG
cord-006439-q7m4srvp	192	9	cells	cell	NNS
cord-006439-q7m4srvp	192	10	of	of	IN
cord-006439-q7m4srvp	192	11	the	the	DT
cord-006439-q7m4srvp	192	12	supraoptic	supraoptic	JJ
cord-006439-q7m4srvp	192	13	nucleus	nucleus	NN
cord-006439-q7m4srvp	192	14	contribute	contribute	VB
cord-006439-q7m4srvp	192	15	to	to	IN
cord-006439-q7m4srvp	192	16	osmotic	osmotic	JJ
cord-006439-q7m4srvp	192	17	control	control	NN
cord-006439-q7m4srvp	192	18	of	of	IN
cord-006439-q7m4srvp	192	19	vasopressin	vasopressin	NN
cord-006439-q7m4srvp	192	20	Clinical	clinical	JJ
cord-006439-q7m4srvp	192	21	relevance	relevance	NN
cord-006439-q7m4srvp	192	22	and	and	CC
cord-006439-q7m4srvp	192	23	role	role	NN
cord-006439-q7m4srvp	192	24	of	of	IN
cord-006439-q7m4srvp	192	25	neuronal	neuronal	JJ
cord-006439-q7m4srvp	192	26	AT1	at1	NN
cord-006439-q7m4srvp	192	27	receptors	receptor	NNS
cord-006439-q7m4srvp	192	28	in	in	IN
cord-006439-q7m4srvp	192	29	ADAM17-mediated	ADAM17-mediated	NNP
cord-006439-q7m4srvp	192	30	ACE2	ACE2	NNP
cord-006439-q7m4srvp	192	31	shedding	shed	VBG
cord-006439-q7m4srvp	192	32	in	in	IN
cord-006439-q7m4srvp	192	33	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	192	34	hypertension	hypertension	NN
cord-006439-q7m4srvp	192	35	Prevalence	prevalence	NN
cord-006439-q7m4srvp	192	36	of	of	IN
cord-006439-q7m4srvp	192	37	resistant	resistant	JJ
cord-006439-q7m4srvp	192	38	hypertension	hypertension	NN
cord-006439-q7m4srvp	192	39	in	in	IN
cord-006439-q7m4srvp	192	40	the	the	DT
cord-006439-q7m4srvp	192	41	United	United	NNP
cord-006439-q7m4srvp	192	42	States	States	NNP
cord-006439-q7m4srvp	192	43	Sympathetic	sympathetic	JJ
cord-006439-q7m4srvp	192	44	activation	activation	NN
cord-006439-q7m4srvp	192	45	in	in	IN
cord-006439-q7m4srvp	192	46	resistant	resistant	JJ
cord-006439-q7m4srvp	192	47	hypertension	hypertension	NN
cord-006439-q7m4srvp	192	48	:	:	:
cord-006439-q7m4srvp	192	49	theory	theory	NN
cord-006439-q7m4srvp	192	50	and	and	CC
cord-006439-q7m4srvp	192	51	therapy	therapy	NN
cord-006439-q7m4srvp	192	52	Catecholamines	Catecholamines	NNP
cord-006439-q7m4srvp	192	53	,	,	,
cord-006439-q7m4srvp	192	54	cardiac	cardiac	JJ
cord-006439-q7m4srvp	192	55	beta	beta	JJ
cord-006439-q7m4srvp	192	56	-	-	HYPH
cord-006439-q7m4srvp	192	57	adrenergic	adrenergic	NN
cord-006439-q7m4srvp	192	58	receptors	receptor	NNS
cord-006439-q7m4srvp	192	59	,	,	,
cord-006439-q7m4srvp	192	60	and	and	CC
cord-006439-q7m4srvp	192	61	heart	heart	NN
cord-006439-q7m4srvp	192	62	failure	failure	NN
cord-006439-q7m4srvp	193	1	The	the	DT
cord-006439-q7m4srvp	193	2	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	193	3	gene	gene	NN
cord-006439-q7m4srvp	193	4	is	be	VBZ
cord-006439-q7m4srvp	193	5	expressed	express	VBN
cord-006439-q7m4srvp	193	6	in	in	IN
cord-006439-q7m4srvp	193	7	both	both	DT
cord-006439-q7m4srvp	193	8	astrocytes	astrocyte	NNS
cord-006439-q7m4srvp	193	9	and	and	CC
cord-006439-q7m4srvp	193	10	neurons	neuron	NNS
cord-006439-q7m4srvp	193	11	in	in	IN
cord-006439-q7m4srvp	193	12	murine	murine	JJ
cord-006439-q7m4srvp	193	13	central	central	JJ
cord-006439-q7m4srvp	193	14	nervous	nervous	JJ
cord-006439-q7m4srvp	193	15	system	system	NN
cord-006439-q7m4srvp	193	16	Astrocyte	Astrocyte	NNP
cord-006439-q7m4srvp	193	17	cultures	culture	NNS
cord-006439-q7m4srvp	193	18	derived	derive	VBN
cord-006439-q7m4srvp	193	19	from	from	IN
cord-006439-q7m4srvp	193	20	human	human	JJ
cord-006439-q7m4srvp	193	21	brain	brain	NN
cord-006439-q7m4srvp	193	22	tissue	tissue	NN
cord-006439-q7m4srvp	193	23	express	express	NNP
cord-006439-q7m4srvp	194	1	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	194	2	mRNA	mRNA	NNP
cord-006439-q7m4srvp	194	3	Astrocytes	Astrocytes	NNP
cord-006439-q7m4srvp	194	4	synthesize	synthesize	VBP
cord-006439-q7m4srvp	194	5	angiotensinogen	angiotensinogen	NN
cord-006439-q7m4srvp	194	6	in	in	IN
cord-006439-q7m4srvp	194	7	brain	brain	NN
cord-006439-q7m4srvp	194	8	Angiotensinogen	Angiotensinogen	NNP
cord-006439-q7m4srvp	194	9	production	production	NN
cord-006439-q7m4srvp	194	10	by	by	IN
cord-006439-q7m4srvp	194	11	rat	rat	NN
cord-006439-q7m4srvp	194	12	astroglial	astroglial	JJ
cord-006439-q7m4srvp	194	13	cells	cell	NNS
cord-006439-q7m4srvp	194	14	in	in	IN
cord-006439-q7m4srvp	194	15	vitro	vitro	FW
cord-006439-q7m4srvp	194	16	and	and	CC
cord-006439-q7m4srvp	194	17	in	in	IN
cord-006439-q7m4srvp	194	18	vivo	vivo	FW
cord-006439-q7m4srvp	194	19	Evidence	evidence	NN
cord-006439-q7m4srvp	194	20	for	for	IN
cord-006439-q7m4srvp	194	21	intraventricular	intraventricular	JJ
cord-006439-q7m4srvp	194	22	secretion	secretion	NN
cord-006439-q7m4srvp	194	23	of	of	IN
cord-006439-q7m4srvp	194	24	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	194	25	and	and	CC
cord-006439-q7m4srvp	194	26	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	194	27	by	by	IN
cord-006439-q7m4srvp	194	28	the	the	DT
cord-006439-q7m4srvp	194	29	subfornical	subfornical	JJ
cord-006439-q7m4srvp	194	30	organ	organ	NN
cord-006439-q7m4srvp	194	31	using	use	VBG
cord-006439-q7m4srvp	194	32	transgenic	transgenic	JJ
cord-006439-q7m4srvp	194	33	mice	mouse	NNS
cord-006439-q7m4srvp	194	34	Mapping	Mapping	NNP
cord-006439-q7m4srvp	194	35	of	of	IN
cord-006439-q7m4srvp	194	36	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	194	37	II	II	NNP
cord-006439-q7m4srvp	194	38	receptor	receptor	NN
cord-006439-q7m4srvp	194	39	subtype	subtype	NN
cord-006439-q7m4srvp	194	40	heterogeneity	heterogeneity	NN
cord-006439-q7m4srvp	194	41	in	in	IN
cord-006439-q7m4srvp	194	42	rat	rat	NN
cord-006439-q7m4srvp	194	43	brain	brain	NN
cord-006439-q7m4srvp	194	44	Reporter	reporter	NN
cord-006439-q7m4srvp	194	45	mouse	mouse	NN
cord-006439-q7m4srvp	194	46	strain	strain	NN
cord-006439-q7m4srvp	195	1	provides	provide	VBZ
cord-006439-q7m4srvp	195	2	a	a	DT
cord-006439-q7m4srvp	195	3	novel	novel	JJ
cord-006439-q7m4srvp	195	4	look	look	NN
cord-006439-q7m4srvp	195	5	at	at	IN
cord-006439-q7m4srvp	195	6	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	195	7	type-2	type-2	NNP
cord-006439-q7m4srvp	195	8	receptor	receptor	NN
cord-006439-q7m4srvp	195	9	distribution	distribution	NN
cord-006439-q7m4srvp	195	10	in	in	IN
cord-006439-q7m4srvp	195	11	the	the	DT
cord-006439-q7m4srvp	195	12	central	central	JJ
cord-006439-q7m4srvp	195	13	nervous	nervous	JJ
cord-006439-q7m4srvp	195	14	system	system	NN
cord-006439-q7m4srvp	195	15	A	a	DT
cord-006439-q7m4srvp	195	16	unique	unique	JJ
cord-006439-q7m4srvp	195	17	"	"	``
cord-006439-q7m4srvp	195	18	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	195	19	-	-	HYPH
cord-006439-q7m4srvp	195	20	sensitive	sensitive	JJ
cord-006439-q7m4srvp	195	21	"	"	``
cord-006439-q7m4srvp	195	22	neuronal	neuronal	JJ
cord-006439-q7m4srvp	195	23	population	population	NN
cord-006439-q7m4srvp	195	24	coordinates	coordinate	VBZ
cord-006439-q7m4srvp	195	25	neuroendocrine	neuroendocrine	JJ
cord-006439-q7m4srvp	195	26	,	,	,
cord-006439-q7m4srvp	195	27	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	195	28	,	,	,
cord-006439-q7m4srvp	195	29	and	and	CC
cord-006439-q7m4srvp	195	30	behavioral	behavioral	JJ
cord-006439-q7m4srvp	195	31	responses	response	NNS
cord-006439-q7m4srvp	195	32	to	to	TO
cord-006439-q7m4srvp	195	33	stress	stress	VB
cord-006439-q7m4srvp	195	34	Expression	expression	NN
cord-006439-q7m4srvp	195	35	of	of	IN
cord-006439-q7m4srvp	195	36	AT2	at2	NN
cord-006439-q7m4srvp	195	37	receptors	receptor	NNS
cord-006439-q7m4srvp	195	38	in	in	IN
cord-006439-q7m4srvp	195	39	the	the	DT
cord-006439-q7m4srvp	195	40	developing	develop	VBG
cord-006439-q7m4srvp	195	41	rat	rat	NN
cord-006439-q7m4srvp	195	42	fetus	fetus	NN
cord-006439-q7m4srvp	195	43	Tonin	Tonin	NNP
cord-006439-q7m4srvp	195	44	expression	expression	NN
cord-006439-q7m4srvp	195	45	in	in	IN
cord-006439-q7m4srvp	195	46	the	the	DT
cord-006439-q7m4srvp	195	47	rat	rat	NN
cord-006439-q7m4srvp	195	48	brain	brain	NN
cord-006439-q7m4srvp	195	49	and	and	CC
cord-006439-q7m4srvp	195	50	toninmediated	toninmediate	VBN
cord-006439-q7m4srvp	195	51	central	central	JJ
cord-006439-q7m4srvp	195	52	production	production	NN
cord-006439-q7m4srvp	195	53	of	of	IN
cord-006439-q7m4srvp	195	54	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	195	55	II	II	NNP
cord-006439-q7m4srvp	195	56	Extrarenal	Extrarenal	NNP
cord-006439-q7m4srvp	195	57	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	195	58	-	-	HYPH
cord-006439-q7m4srvp	195	59	forming	form	VBG
cord-006439-q7m4srvp	195	60	enzymes	enzyme	NNS
cord-006439-q7m4srvp	195	61	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	195	62	generation	generation	NN
cord-006439-q7m4srvp	195	63	in	in	IN
cord-006439-q7m4srvp	195	64	the	the	DT
cord-006439-q7m4srvp	195	65	brain	brain	NN
cord-006439-q7m4srvp	195	66	and	and	CC
cord-006439-q7m4srvp	195	67	drinking	drinking	NN
cord-006439-q7m4srvp	195	68	:	:	:
cord-006439-q7m4srvp	195	69	indications	indication	NNS
cord-006439-q7m4srvp	195	70	for	for	IN
cord-006439-q7m4srvp	195	71	the	the	DT
cord-006439-q7m4srvp	195	72	involvement	involvement	NN
cord-006439-q7m4srvp	195	73	of	of	IN
cord-006439-q7m4srvp	195	74	endopeptidase	endopeptidase	NN
cord-006439-q7m4srvp	195	75	activity	activity	NN
cord-006439-q7m4srvp	195	76	distinct	distinct	JJ
cord-006439-q7m4srvp	195	77	from	from	IN
cord-006439-q7m4srvp	195	78	cathepsin	cathepsin	NN
cord-006439-q7m4srvp	195	79	D	D	NNP
cord-006439-q7m4srvp	195	80	Chronic	Chronic	NNP
cord-006439-q7m4srvp	195	81	immunoneutralization	immunoneutralization	NN
cord-006439-q7m4srvp	195	82	of	of	IN
cord-006439-q7m4srvp	195	83	brain	brain	NN
cord-006439-q7m4srvp	195	84	angiotensin-(1	angiotensin-(1	CD
cord-006439-q7m4srvp	195	85	-	-	HYPH
cord-006439-q7m4srvp	195	86	12	12	CD
cord-006439-q7m4srvp	195	87	)	)	-RRB-
cord-006439-q7m4srvp	195	88	lowers	lower	VBZ
cord-006439-q7m4srvp	195	89	blood	blood	NN
cord-006439-q7m4srvp	195	90	pressure	pressure	NN
cord-006439-q7m4srvp	195	91	in	in	IN
cord-006439-q7m4srvp	195	92	transgenic	transgenic	JJ
cord-006439-q7m4srvp	195	93	(	(	-LRB-
cord-006439-q7m4srvp	195	94	mRen2)27	mren2)27	CD
cord-006439-q7m4srvp	195	95	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	195	96	rats	rat	NNS
cord-006439-q7m4srvp	195	97	Brain	Brain	NNP
cord-006439-q7m4srvp	195	98	renin	renin	NN
cord-006439-q7m4srvp	195	99	-	-	HYPH
cord-006439-q7m4srvp	195	100	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	195	101	system	system	NN
cord-006439-q7m4srvp	195	102	:	:	:
cord-006439-q7m4srvp	195	103	does	do	VBZ
cord-006439-q7m4srvp	195	104	it	-PRON-	PRP
cord-006439-q7m4srvp	195	105	exist	exist	VB
cord-006439-q7m4srvp	195	106	?	?	.
cord-006439-q7m4srvp	196	1	Hypertension	hypertension	NN
cord-006439-q7m4srvp	196	2	Local	local	JJ
cord-006439-q7m4srvp	196	3	production	production	NN
cord-006439-q7m4srvp	196	4	of	of	IN
cord-006439-q7m4srvp	196	5	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	196	6	II	II	NNP
cord-006439-q7m4srvp	196	7	in	in	IN
cord-006439-q7m4srvp	196	8	the	the	DT
cord-006439-q7m4srvp	196	9	subfornical	subfornical	JJ
cord-006439-q7m4srvp	196	10	organ	organ	NN
cord-006439-q7m4srvp	196	11	causes	cause	VBZ
cord-006439-q7m4srvp	196	12	elevated	elevate	VBN
cord-006439-q7m4srvp	196	13	drinking	drink	VBG
cord-006439-q7m4srvp	196	14	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	196	15	AT1A	AT1A	NNP
cord-006439-q7m4srvp	196	16	receptors	receptor	NNS
cord-006439-q7m4srvp	196	17	on	on	IN
cord-006439-q7m4srvp	196	18	leptin	leptin	NN
cord-006439-q7m4srvp	196	19	receptor	receptor	NN
cord-006439-q7m4srvp	196	20	-	-	HYPH
cord-006439-q7m4srvp	196	21	expressing	express	VBG
cord-006439-q7m4srvp	196	22	cells	cell	NNS
cord-006439-q7m4srvp	196	23	control	control	NN
cord-006439-q7m4srvp	196	24	resting	rest	VBG
cord-006439-q7m4srvp	196	25	metabolism	metabolism	NN
cord-006439-q7m4srvp	197	1	The	the	DT
cord-006439-q7m4srvp	197	2	brain	brain	NN
cord-006439-q7m4srvp	197	3	renin	renin	NN
cord-006439-q7m4srvp	197	4	-	-	HYPH
cord-006439-q7m4srvp	197	5	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	197	6	system	system	NN
cord-006439-q7m4srvp	197	7	and	and	CC
cord-006439-q7m4srvp	197	8	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	197	9	responses	response	NNS
cord-006439-q7m4srvp	197	10	to	to	IN
cord-006439-q7m4srvp	197	11	stress	stress	NN
cord-006439-q7m4srvp	197	12	:	:	:
cord-006439-q7m4srvp	197	13	insights	insight	NNS
cord-006439-q7m4srvp	197	14	from	from	IN
cord-006439-q7m4srvp	197	15	transgenic	transgenic	JJ
cord-006439-q7m4srvp	197	16	rats	rat	NNS
cord-006439-q7m4srvp	197	17	with	with	IN
cord-006439-q7m4srvp	197	18	low	low	JJ
cord-006439-q7m4srvp	197	19	brain	brain	NN
cord-006439-q7m4srvp	197	20	angiotensinogen	angiotensinogen	NN
cord-006439-q7m4srvp	197	21	Distinct	distinct	JJ
cord-006439-q7m4srvp	197	22	renin	renin	NN
cord-006439-q7m4srvp	197	23	isoforms	isoform	NNS
cord-006439-q7m4srvp	197	24	generated	generate	VBN
cord-006439-q7m4srvp	197	25	by	by	IN
cord-006439-q7m4srvp	197	26	tissue	tissue	NN
cord-006439-q7m4srvp	197	27	-	-	HYPH
cord-006439-q7m4srvp	197	28	specific	specific	JJ
cord-006439-q7m4srvp	197	29	transcription	transcription	NN
cord-006439-q7m4srvp	197	30	initiation	initiation	NN
cord-006439-q7m4srvp	197	31	and	and	CC
cord-006439-q7m4srvp	197	32	alternative	alternative	JJ
cord-006439-q7m4srvp	197	33	splicing	splicing	NN
cord-006439-q7m4srvp	197	34	Identification	identification	NN
cord-006439-q7m4srvp	197	35	of	of	IN
cord-006439-q7m4srvp	197	36	three	three	CD
cord-006439-q7m4srvp	197	37	human	human	JJ
cord-006439-q7m4srvp	197	38	renin	renin	NN
cord-006439-q7m4srvp	197	39	mRNA	mRNA	NNP
cord-006439-q7m4srvp	197	40	isoforms	isoform	NNS
cord-006439-q7m4srvp	197	41	from	from	IN
cord-006439-q7m4srvp	197	42	alternative	alternative	JJ
cord-006439-q7m4srvp	197	43	tissue	tissue	NN
cord-006439-q7m4srvp	197	44	-	-	HYPH
cord-006439-q7m4srvp	197	45	specific	specific	JJ
cord-006439-q7m4srvp	197	46	transcriptional	transcriptional	JJ
cord-006439-q7m4srvp	197	47	initiation	initiation	NN
cord-006439-q7m4srvp	198	1	A	a	DT
cord-006439-q7m4srvp	198	2	renin	renin	NN
cord-006439-q7m4srvp	198	3	transcript	transcript	NN
cord-006439-q7m4srvp	198	4	lacking	lack	VBG
cord-006439-q7m4srvp	198	5	exon	exon	NN
cord-006439-q7m4srvp	198	6	1	1	CD
cord-006439-q7m4srvp	198	7	encodes	encode	VBZ
cord-006439-q7m4srvp	198	8	for	for	IN
cord-006439-q7m4srvp	198	9	a	a	DT
cord-006439-q7m4srvp	198	10	non	non	JJ
cord-006439-q7m4srvp	198	11	-	-	JJ
cord-006439-q7m4srvp	198	12	secretory	secretory	JJ
cord-006439-q7m4srvp	198	13	intracellular	intracellular	JJ
cord-006439-q7m4srvp	198	14	renin	renin	NN
cord-006439-q7m4srvp	198	15	that	that	WDT
cord-006439-q7m4srvp	198	16	increases	increase	VBZ
cord-006439-q7m4srvp	198	17	aldosterone	aldosterone	NN
cord-006439-q7m4srvp	198	18	production	production	NN
cord-006439-q7m4srvp	198	19	in	in	IN
cord-006439-q7m4srvp	198	20	transgenic	transgenic	JJ
cord-006439-q7m4srvp	198	21	rats	rat	NNS
cord-006439-q7m4srvp	199	1	Role	role	NN
cord-006439-q7m4srvp	199	2	of	of	IN
cord-006439-q7m4srvp	199	3	intracellular	intracellular	JJ
cord-006439-q7m4srvp	199	4	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	199	5	II	II	NNP
cord-006439-q7m4srvp	199	6	High	High	NNP
cord-006439-q7m4srvp	199	7	-	-	HYPH
cord-006439-q7m4srvp	199	8	glucoseinduced	glucoseinduce	VBN
cord-006439-q7m4srvp	199	9	regulation	regulation	NN
cord-006439-q7m4srvp	199	10	of	of	IN
cord-006439-q7m4srvp	199	11	intracellular	intracellular	JJ
cord-006439-q7m4srvp	199	12	ANG	ANG	NNP
cord-006439-q7m4srvp	199	13	II	II	NNP
cord-006439-q7m4srvp	199	14	synthesis	synthesis	NN
cord-006439-q7m4srvp	199	15	and	and	CC
cord-006439-q7m4srvp	199	16	nuclear	nuclear	JJ
cord-006439-q7m4srvp	199	17	redistribution	redistribution	NN
cord-006439-q7m4srvp	199	18	in	in	IN
cord-006439-q7m4srvp	199	19	cardiac	cardiac	JJ
cord-006439-q7m4srvp	199	20	myocytes	myocyte	NNS
cord-006439-q7m4srvp	200	1	An	an	DT
cord-006439-q7m4srvp	200	2	intracellular	intracellular	JJ
cord-006439-q7m4srvp	200	3	renin	renin	NN
cord-006439-q7m4srvp	200	4	-	-	HYPH
cord-006439-q7m4srvp	200	5	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	200	6	system	system	NN
cord-006439-q7m4srvp	200	7	in	in	IN
cord-006439-q7m4srvp	200	8	neurons	neuron	NNS
cord-006439-q7m4srvp	200	9	:	:	:
cord-006439-q7m4srvp	200	10	fact	fact	NN
cord-006439-q7m4srvp	200	11	,	,	,
cord-006439-q7m4srvp	200	12	hypothesis	hypothesis	NN
cord-006439-q7m4srvp	200	13	,	,	,
cord-006439-q7m4srvp	200	14	or	or	CC
cord-006439-q7m4srvp	200	15	fantasy	fantasy	NN
cord-006439-q7m4srvp	201	1	This	this	DT
cord-006439-q7m4srvp	201	2	study	study	NN
cord-006439-q7m4srvp	201	3	describes	describe	VBZ
cord-006439-q7m4srvp	201	4	how	how	WRB
cord-006439-q7m4srvp	201	5	a	a	DT
cord-006439-q7m4srvp	201	6	selective	selective	JJ
cord-006439-q7m4srvp	201	7	ablation	ablation	NN
cord-006439-q7m4srvp	201	8	of	of	IN
cord-006439-q7m4srvp	201	9	the	the	DT
cord-006439-q7m4srvp	201	10	alternative	alternative	JJ
cord-006439-q7m4srvp	201	11	intracellular	intracellular	JJ
cord-006439-q7m4srvp	201	12	renin	renin	NN
cord-006439-q7m4srvp	201	13	isoform	isoform	NN
cord-006439-q7m4srvp	201	14	leads	lead	VBZ
cord-006439-q7m4srvp	201	15	to	to	IN
cord-006439-q7m4srvp	201	16	paradoxical	paradoxical	JJ
cord-006439-q7m4srvp	201	17	elevation	elevation	NN
cord-006439-q7m4srvp	201	18	of	of	IN
cord-006439-q7m4srvp	201	19	angiotensinergic	angiotensinergic	NNP
cord-006439-q7m4srvp	201	20	signaling	signal	VBG
cord-006439-q7m4srvp	201	21	Reference	reference	NN
cord-006439-q7m4srvp	201	22	values	value	NNS
cord-006439-q7m4srvp	201	23	for	for	IN
cord-006439-q7m4srvp	201	24	resting	rest	VBG
cord-006439-q7m4srvp	201	25	blood	blood	NN
cord-006439-q7m4srvp	201	26	flow	flow	NN
cord-006439-q7m4srvp	201	27	to	to	IN
cord-006439-q7m4srvp	201	28	organs	organ	NNS
cord-006439-q7m4srvp	201	29	of	of	IN
cord-006439-q7m4srvp	201	30	man	man	NN
cord-006439-q7m4srvp	201	31	Soluble	soluble	JJ
cord-006439-q7m4srvp	201	32	(	(	-LRB-
cord-006439-q7m4srvp	201	33	pro)renin	pro)renin	RB
cord-006439-q7m4srvp	202	1	receptor	receptor	NN
cord-006439-q7m4srvp	202	2	via	via	IN
cord-006439-q7m4srvp	202	3	beta	beta	NN
cord-006439-q7m4srvp	202	4	-	-	HYPH
cord-006439-q7m4srvp	202	5	catenin	catenin	NN
cord-006439-q7m4srvp	202	6	enhances	enhance	VBZ
cord-006439-q7m4srvp	202	7	urine	urine	NN
cord-006439-q7m4srvp	202	8	concentration	concentration	NN
cord-006439-q7m4srvp	202	9	capability	capability	NN
cord-006439-q7m4srvp	202	10	as	as	IN
cord-006439-q7m4srvp	202	11	a	a	DT
cord-006439-q7m4srvp	202	12	target	target	NN
cord-006439-q7m4srvp	202	13	of	of	IN
cord-006439-q7m4srvp	202	14	liver	liver	NN
cord-006439-q7m4srvp	202	15	X	x	NN
cord-006439-q7m4srvp	202	16	receptor	receptor	NN
cord-006439-q7m4srvp	202	17	Distribution	distribution	NN
cord-006439-q7m4srvp	202	18	of	of	IN
cord-006439-q7m4srvp	202	19	immunoreactive	immunoreactive	JJ
cord-006439-q7m4srvp	202	20	angiotensin	angiotensin	NNP
cord-006439-q7m4srvp	202	21	II	II	NNP
cord-006439-q7m4srvp	202	22	,	,	,
cord-006439-q7m4srvp	202	23	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	202	24	I	-PRON-	PRP
cord-006439-q7m4srvp	202	25	,	,	,
cord-006439-q7m4srvp	202	26	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	202	27	and	and	CC
cord-006439-q7m4srvp	202	28	renin	renin	NN
cord-006439-q7m4srvp	202	29	in	in	IN
cord-006439-q7m4srvp	202	30	the	the	DT
cord-006439-q7m4srvp	202	31	central	central	JJ
cord-006439-q7m4srvp	202	32	nervous	nervous	JJ
cord-006439-q7m4srvp	202	33	system	system	NN
cord-006439-q7m4srvp	202	34	of	of	IN
cord-006439-q7m4srvp	202	35	intact	intact	JJ
cord-006439-q7m4srvp	202	36	and	and	CC
cord-006439-q7m4srvp	202	37	nephrectomized	nephrectomized	JJ
cord-006439-q7m4srvp	202	38	rats	rat	NNS
cord-006439-q7m4srvp	203	1	The	the	DT
cord-006439-q7m4srvp	203	2	distribution	distribution	NN
cord-006439-q7m4srvp	203	3	of	of	IN
cord-006439-q7m4srvp	203	4	immunoreactive	immunoreactive	JJ
cord-006439-q7m4srvp	203	5	angiotensins	angiotensins	NNP
cord-006439-q7m4srvp	203	6	I	I	NNP
cord-006439-q7m4srvp	203	7	and	and	CC
cord-006439-q7m4srvp	203	8	II	II	NNP
cord-006439-q7m4srvp	203	9	extracted	extract	VBN
cord-006439-q7m4srvp	203	10	from	from	IN
cord-006439-q7m4srvp	203	11	rat	rat	NN
cord-006439-q7m4srvp	203	12	brain	brain	NN
cord-006439-q7m4srvp	203	13	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	203	14	II	II	NNP
cord-006439-q7m4srvp	203	15	in	in	IN
cord-006439-q7m4srvp	203	16	rat	rat	NN
cord-006439-q7m4srvp	203	17	brain	brain	NN
cord-006439-q7m4srvp	203	18	comigrates	comigrate	NNS
cord-006439-q7m4srvp	203	19	with	with	IN
cord-006439-q7m4srvp	203	20	authentic	authentic	JJ
cord-006439-q7m4srvp	203	21	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	203	22	II	II	NNP
cord-006439-q7m4srvp	203	23	in	in	IN
cord-006439-q7m4srvp	203	24	high	high	JJ
cord-006439-q7m4srvp	203	25	pressure	pressure	NN
cord-006439-q7m4srvp	203	26	liquid	liquid	NN
cord-006439-q7m4srvp	203	27	chromatography	chromatography	NN
cord-006439-q7m4srvp	203	28	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	203	29	biosynthesis	biosynthesis	NN
cord-006439-q7m4srvp	203	30	and	and	CC
cord-006439-q7m4srvp	203	31	concentrations	concentration	NNS
cord-006439-q7m4srvp	203	32	in	in	IN
cord-006439-q7m4srvp	203	33	brain	brain	NN
cord-006439-q7m4srvp	203	34	of	of	IN
cord-006439-q7m4srvp	203	35	normotensive	normotensive	JJ
cord-006439-q7m4srvp	203	36	and	and	CC
cord-006439-q7m4srvp	203	37	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	203	38	rats	rat	NNS
cord-006439-q7m4srvp	203	39	Definitive	definitive	JJ
cord-006439-q7m4srvp	203	40	evidence	evidence	NN
cord-006439-q7m4srvp	203	41	for	for	IN
cord-006439-q7m4srvp	203	42	renin	renin	NN
cord-006439-q7m4srvp	203	43	in	in	IN
cord-006439-q7m4srvp	203	44	rat	rat	NN
cord-006439-q7m4srvp	203	45	brain	brain	NN
cord-006439-q7m4srvp	203	46	by	by	IN
cord-006439-q7m4srvp	203	47	affinity	affinity	NN
cord-006439-q7m4srvp	203	48	chromatographic	chromatographic	JJ
cord-006439-q7m4srvp	203	49	separation	separation	NN
cord-006439-q7m4srvp	203	50	from	from	IN
cord-006439-q7m4srvp	203	51	protease	protease	NN
cord-006439-q7m4srvp	203	52	Identification	identification	NN
cord-006439-q7m4srvp	203	53	of	of	IN
cord-006439-q7m4srvp	203	54	renin	renin	NN
cord-006439-q7m4srvp	203	55	and	and	CC
cord-006439-q7m4srvp	203	56	renin	renin	NN
cord-006439-q7m4srvp	203	57	-	-	HYPH
cord-006439-q7m4srvp	203	58	like	like	JJ
cord-006439-q7m4srvp	203	59	enzymes	enzyme	NNS
cord-006439-q7m4srvp	203	60	in	in	IN
cord-006439-q7m4srvp	203	61	rat	rat	NN
cord-006439-q7m4srvp	203	62	brain	brain	NN
cord-006439-q7m4srvp	203	63	by	by	IN
cord-006439-q7m4srvp	203	64	a	a	DT
cord-006439-q7m4srvp	203	65	renin	renin	NN
cord-006439-q7m4srvp	203	66	-	-	HYPH
cord-006439-q7m4srvp	203	67	specific	specific	JJ
cord-006439-q7m4srvp	203	68	antibody	antibody	NN
cord-006439-q7m4srvp	203	69	Angiotensin	angiotensin	NN
cord-006439-q7m4srvp	203	70	-	-	HYPH
cord-006439-q7m4srvp	203	71	forming	form	VBG
cord-006439-q7m4srvp	203	72	enzyme	enzyme	NN
cord-006439-q7m4srvp	203	73	in	in	IN
cord-006439-q7m4srvp	203	74	brain	brain	NN
cord-006439-q7m4srvp	203	75	tissue	tissue	NN
cord-006439-q7m4srvp	203	76	Angiotensin	angiotensin	NN
cord-006439-q7m4srvp	203	77	-	-	HYPH
cord-006439-q7m4srvp	203	78	forming	form	VBG
cord-006439-q7m4srvp	203	79	enzyme	enzyme	NN
cord-006439-q7m4srvp	203	80	active	active	JJ
cord-006439-q7m4srvp	203	81	at	at	IN
cord-006439-q7m4srvp	203	82	the	the	DT
cord-006439-q7m4srvp	203	83	physiological	physiological	JJ
cord-006439-q7m4srvp	203	84	Ph	Ph	NNP
cord-006439-q7m4srvp	203	85	in	in	IN
cord-006439-q7m4srvp	203	86	the	the	DT
cord-006439-q7m4srvp	203	87	brain	brain	NN
cord-006439-q7m4srvp	203	88	of	of	IN
cord-006439-q7m4srvp	203	89	normal	normal	JJ
cord-006439-q7m4srvp	203	90	and	and	CC
cord-006439-q7m4srvp	203	91	nephrectomized	nephrectomized	JJ
cord-006439-q7m4srvp	203	92	rats	rat	NNS
cord-006439-q7m4srvp	204	1	Adjacent	adjacent	JJ
cord-006439-q7m4srvp	204	2	expression	expression	NN
cord-006439-q7m4srvp	204	3	of	of	IN
cord-006439-q7m4srvp	204	4	renin	renin	NN
cord-006439-q7m4srvp	204	5	and	and	CC
cord-006439-q7m4srvp	204	6	angiotensinogen	angiotensinogen	NNP
cord-006439-q7m4srvp	204	7	in	in	IN
cord-006439-q7m4srvp	204	8	the	the	DT
cord-006439-q7m4srvp	204	9	rostral	rostral	JJ
cord-006439-q7m4srvp	204	10	ventrolateral	ventrolateral	JJ
cord-006439-q7m4srvp	204	11	medulla	medulla	NN
cord-006439-q7m4srvp	204	12	using	use	VBG
cord-006439-q7m4srvp	204	13	a	a	DT
cord-006439-q7m4srvp	204	14	dual	dual	JJ
cord-006439-q7m4srvp	204	15	-	-	HYPH
cord-006439-q7m4srvp	204	16	reporter	reporter	NN
cord-006439-q7m4srvp	204	17	transgenic	transgenic	JJ
cord-006439-q7m4srvp	204	18	model	model	NN
cord-006439-q7m4srvp	204	19	Localization	Localization	NNP
cord-006439-q7m4srvp	204	20	of	of	IN
cord-006439-q7m4srvp	204	21	renin	renin	NN
cord-006439-q7m4srvp	204	22	expressing	express	VBG
cord-006439-q7m4srvp	204	23	cells	cell	NNS
cord-006439-q7m4srvp	204	24	in	in	IN
cord-006439-q7m4srvp	204	25	the	the	DT
cord-006439-q7m4srvp	204	26	brain	brain	NN
cord-006439-q7m4srvp	204	27	,	,	,
cord-006439-q7m4srvp	204	28	by	by	IN
cord-006439-q7m4srvp	204	29	use	use	NN
cord-006439-q7m4srvp	204	30	of	of	IN
cord-006439-q7m4srvp	204	31	a	a	DT
cord-006439-q7m4srvp	204	32	REN	REN	NNP
cord-006439-q7m4srvp	204	33	-	-	HYPH
cord-006439-q7m4srvp	204	34	eGFP	egfp	JJ
cord-006439-q7m4srvp	204	35	transgenic	transgenic	JJ
cord-006439-q7m4srvp	204	36	model	model	NN
cord-006439-q7m4srvp	204	37	Revisiting	revisit	VBG
cord-006439-q7m4srvp	204	38	the	the	DT
cord-006439-q7m4srvp	204	39	brain	brain	NN
cord-006439-q7m4srvp	204	40	renin	renin	NN
cord-006439-q7m4srvp	204	41	-	-	HYPH
cord-006439-q7m4srvp	204	42	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	204	43	system	system	NN
cord-006439-q7m4srvp	204	44	-	-	HYPH
cord-006439-q7m4srvp	204	45	focus	focus	NN
cord-006439-q7m4srvp	204	46	on	on	IN
cord-006439-q7m4srvp	204	47	novel	novel	JJ
cord-006439-q7m4srvp	204	48	therapies	therapy	NNS
cord-006439-q7m4srvp	204	49	Totally	totally	RB
cord-006439-q7m4srvp	204	50	inactive	inactive	JJ
cord-006439-q7m4srvp	204	51	renin	renin	NN
cord-006439-q7m4srvp	204	52	zymogen	zymogen	NN
cord-006439-q7m4srvp	204	53	and	and	CC
cord-006439-q7m4srvp	204	54	different	different	JJ
cord-006439-q7m4srvp	204	55	forms	form	NNS
cord-006439-q7m4srvp	204	56	of	of	IN
cord-006439-q7m4srvp	204	57	active	active	JJ
cord-006439-q7m4srvp	204	58	renin	renin	NN
cord-006439-q7m4srvp	204	59	in	in	IN
cord-006439-q7m4srvp	204	60	hog	hog	NN
cord-006439-q7m4srvp	204	61	brain	brain	NN
cord-006439-q7m4srvp	204	62	tissues	tissue	VBZ
cord-006439-q7m4srvp	204	63	Pivotal	pivotal	JJ
cord-006439-q7m4srvp	204	64	role	role	NN
cord-006439-q7m4srvp	204	65	of	of	IN
cord-006439-q7m4srvp	204	66	the	the	DT
cord-006439-q7m4srvp	204	67	renin	renin	NN
cord-006439-q7m4srvp	204	68	/	/	SYM
cord-006439-q7m4srvp	204	69	prorenin	prorenin	NN
cord-006439-q7m4srvp	204	70	receptor	receptor	NN
cord-006439-q7m4srvp	204	71	in	in	IN
cord-006439-q7m4srvp	204	72	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	204	73	II	ii	CD
cord-006439-q7m4srvp	204	74	production	production	NN
cord-006439-q7m4srvp	204	75	and	and	CC
cord-006439-q7m4srvp	204	76	cellular	cellular	JJ
cord-006439-q7m4srvp	204	77	responses	response	NNS
cord-006439-q7m4srvp	204	78	to	to	IN
cord-006439-q7m4srvp	204	79	renin	renin	NN
cord-006439-q7m4srvp	204	80	Utilizing	utilize	VBG
cord-006439-q7m4srvp	204	81	a	a	DT
cord-006439-q7m4srvp	204	82	novel	novel	JJ
cord-006439-q7m4srvp	204	83	calcium	calcium	NN
cord-006439-q7m4srvp	204	84	biosensor	biosensor	NN
cord-006439-q7m4srvp	204	85	,	,	,
cord-006439-q7m4srvp	204	86	the	the	DT
cord-006439-q7m4srvp	204	87	authors	author	NNS
cord-006439-q7m4srvp	204	88	demonstrate	demonstrate	VBP
cord-006439-q7m4srvp	204	89	that	that	IN
cord-006439-q7m4srvp	204	90	ablation	ablation	NN
cord-006439-q7m4srvp	204	91	of	of	IN
cord-006439-q7m4srvp	204	92	prorenin	prorenin	JJ
cord-006439-q7m4srvp	204	93	receptor	receptor	NN
cord-006439-q7m4srvp	204	94	in	in	IN
cord-006439-q7m4srvp	204	95	the	the	DT
cord-006439-q7m4srvp	204	96	paraventricular	paraventricular	NNP
cord-006439-q7m4srvp	204	97	nucleus	nucleus	NNP
cord-006439-q7m4srvp	204	98	attenuates	attenuate	VBZ
cord-006439-q7m4srvp	204	99	angiotensin	angiotensin	JJ
cord-006439-q7m4srvp	204	100	IIinduced	iiinduced	JJ
cord-006439-q7m4srvp	204	101	calcium	calcium	NN
cord-006439-q7m4srvp	204	102	signaling	signal	VBG
cord-006439-q7m4srvp	204	103	in	in	IN
cord-006439-q7m4srvp	204	104	hypertension	hypertension	NN
cord-006439-q7m4srvp	205	1	The	the	DT
cord-006439-q7m4srvp	205	2	critical	critical	JJ
cord-006439-q7m4srvp	205	3	role	role	NN
cord-006439-q7m4srvp	205	4	of	of	IN
cord-006439-q7m4srvp	205	5	the	the	DT
cord-006439-q7m4srvp	205	6	central	central	JJ
cord-006439-q7m4srvp	205	7	nervous	nervous	JJ
cord-006439-q7m4srvp	205	8	system	system	NN
cord-006439-q7m4srvp	205	9	(	(	-LRB-
cord-006439-q7m4srvp	205	10	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	205	11	receptor	receptor	NN
cord-006439-q7m4srvp	205	12	in	in	IN
cord-006439-q7m4srvp	205	13	regulating	regulate	VBG
cord-006439-q7m4srvp	205	14	systemic	systemic	JJ
cord-006439-q7m4srvp	205	15	blood	blood	NN
cord-006439-q7m4srvp	205	16	pressure	pressure	NN
cord-006439-q7m4srvp	205	17	Roles	role	NNS
cord-006439-q7m4srvp	205	18	and	and	CC
cord-006439-q7m4srvp	205	19	functions	function	NNS
cord-006439-q7m4srvp	205	20	of	of	IN
cord-006439-q7m4srvp	205	21	Atp6ap2	atp6ap2	CD
cord-006439-q7m4srvp	205	22	in	in	IN
cord-006439-q7m4srvp	205	23	the	the	DT
cord-006439-q7m4srvp	205	24	brain	brain	NN
cord-006439-q7m4srvp	206	1	Renal	renal	JJ
cord-006439-q7m4srvp	206	2	Atp6ap2/(pro)renin	atp6ap2/(pro)renin	JJ
cord-006439-q7m4srvp	206	3	receptor	receptor	NN
cord-006439-q7m4srvp	206	4	is	be	VBZ
cord-006439-q7m4srvp	206	5	required	require	VBN
cord-006439-q7m4srvp	206	6	for	for	IN
cord-006439-q7m4srvp	206	7	normal	normal	JJ
cord-006439-q7m4srvp	206	8	vacuolar	vacuolar	NN
cord-006439-q7m4srvp	206	9	H+-ATPase	h+-atpase	IN
cord-006439-q7m4srvp	206	10	function	function	NN
cord-006439-q7m4srvp	206	11	but	but	CC
cord-006439-q7m4srvp	206	12	not	not	RB
cord-006439-q7m4srvp	206	13	for	for	IN
cord-006439-q7m4srvp	206	14	the	the	DT
cord-006439-q7m4srvp	206	15	renin	renin	NN
cord-006439-q7m4srvp	206	16	-	-	HYPH
cord-006439-q7m4srvp	206	17	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	206	18	system	system	NN
cord-006439-q7m4srvp	207	1	A	a	DT
cord-006439-q7m4srvp	207	2	unique	unique	JJ
cord-006439-q7m4srvp	207	3	exonic	exonic	NN
cord-006439-q7m4srvp	207	4	splice	splice	NN
cord-006439-q7m4srvp	207	5	enhancer	enhancer	NN
cord-006439-q7m4srvp	207	6	mutation	mutation	NN
cord-006439-q7m4srvp	207	7	in	in	IN
cord-006439-q7m4srvp	207	8	a	a	DT
cord-006439-q7m4srvp	207	9	family	family	NN
cord-006439-q7m4srvp	207	10	with	with	IN
cord-006439-q7m4srvp	207	11	X	x	NN
cord-006439-q7m4srvp	207	12	-	-	HYPH
cord-006439-q7m4srvp	207	13	linked	link	VBN
cord-006439-q7m4srvp	207	14	mental	mental	JJ
cord-006439-q7m4srvp	207	15	retardation	retardation	NN
cord-006439-q7m4srvp	207	16	and	and	CC
cord-006439-q7m4srvp	207	17	epilepsy	epilepsy	NN
cord-006439-q7m4srvp	207	18	points	point	VBZ
cord-006439-q7m4srvp	207	19	to	to	IN
cord-006439-q7m4srvp	207	20	a	a	DT
cord-006439-q7m4srvp	207	21	novel	novel	JJ
cord-006439-q7m4srvp	207	22	role	role	NN
cord-006439-q7m4srvp	207	23	of	of	IN
cord-006439-q7m4srvp	207	24	the	the	DT
cord-006439-q7m4srvp	207	25	renin	renin	NN
cord-006439-q7m4srvp	207	26	receptor	receptor	NN
cord-006439-q7m4srvp	207	27	(	(	-LRB-
cord-006439-q7m4srvp	207	28	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	207	29	receptor	receptor	NN
cord-006439-q7m4srvp	207	30	and	and	CC
cord-006439-q7m4srvp	207	31	autophagy	autophagy	NN
cord-006439-q7m4srvp	207	32	in	in	IN
cord-006439-q7m4srvp	207	33	podocytes	podocyte	NNS
cord-006439-q7m4srvp	208	1	Pro)renin	Pro)renin	NNP
cord-006439-q7m4srvp	208	2	receptor	receptor	NN
cord-006439-q7m4srvp	208	3	regulates	regulate	VBZ
cord-006439-q7m4srvp	208	4	autophagy	autophagy	NN
cord-006439-q7m4srvp	208	5	and	and	CC
cord-006439-q7m4srvp	208	6	apoptosis	apoptosis	NN
cord-006439-q7m4srvp	208	7	in	in	IN
cord-006439-q7m4srvp	208	8	podocytes	podocyte	NNS
cord-006439-q7m4srvp	208	9	exposed	expose	VBN
cord-006439-q7m4srvp	208	10	to	to	IN
cord-006439-q7m4srvp	208	11	high	high	JJ
cord-006439-q7m4srvp	208	12	glucose	glucose	NN
cord-006439-q7m4srvp	208	13	Nephron	Nephron	NNP
cord-006439-q7m4srvp	208	14	-	-	HYPH
cord-006439-q7m4srvp	208	15	specific	specific	JJ
cord-006439-q7m4srvp	208	16	deletion	deletion	NN
cord-006439-q7m4srvp	208	17	of	of	IN
cord-006439-q7m4srvp	208	18	the	the	DT
cord-006439-q7m4srvp	208	19	prorenin	prorenin	JJ
cord-006439-q7m4srvp	208	20	receptor	receptor	NN
cord-006439-q7m4srvp	208	21	causes	cause	VBZ
cord-006439-q7m4srvp	208	22	a	a	DT
cord-006439-q7m4srvp	208	23	urine	urine	NN
cord-006439-q7m4srvp	208	24	concentration	concentration	NN
cord-006439-q7m4srvp	208	25	defect	defect	NN
cord-006439-q7m4srvp	208	26	Central	central	JJ
cord-006439-q7m4srvp	208	27	renin	renin	NN
cord-006439-q7m4srvp	208	28	-	-	HYPH
cord-006439-q7m4srvp	208	29	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	208	30	system	system	NN
cord-006439-q7m4srvp	208	31	and	and	CC
cord-006439-q7m4srvp	208	32	the	the	DT
cord-006439-q7m4srvp	208	33	pathogenesis	pathogenesis	NN
cord-006439-q7m4srvp	208	34	of	of	IN
cord-006439-q7m4srvp	208	35	DOCA	DOCA	NNP
cord-006439-q7m4srvp	208	36	-	-	HYPH
cord-006439-q7m4srvp	208	37	salt	salt	NN
cord-006439-q7m4srvp	208	38	hypertension	hypertension	NN
cord-006439-q7m4srvp	208	39	in	in	IN
cord-006439-q7m4srvp	208	40	rats	rat	NNS
cord-006439-q7m4srvp	209	1	An	an	DT
cord-006439-q7m4srvp	209	2	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	209	3	system	system	NN
cord-006439-q7m4srvp	209	4	in	in	IN
cord-006439-q7m4srvp	209	5	the	the	DT
cord-006439-q7m4srvp	209	6	anterior	anterior	NNP
cord-006439-q7m4srvp	209	7	hypothalamic	hypothalamic	JJ
cord-006439-q7m4srvp	209	8	area	area	NN
cord-006439-q7m4srvp	209	9	anterior	anterior	NNP
cord-006439-q7m4srvp	209	10	is	be	VBZ
cord-006439-q7m4srvp	209	11	involved	involve	VBN
cord-006439-q7m4srvp	209	12	in	in	IN
cord-006439-q7m4srvp	209	13	the	the	DT
cord-006439-q7m4srvp	209	14	maintenance	maintenance	NN
cord-006439-q7m4srvp	209	15	of	of	IN
cord-006439-q7m4srvp	209	16	hypertension	hypertension	NN
cord-006439-q7m4srvp	209	17	in	in	IN
cord-006439-q7m4srvp	209	18	spontaneously	spontaneously	RB
cord-006439-q7m4srvp	209	19	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	209	20	rats	rat	NNS
cord-006439-q7m4srvp	210	1	Effects	effect	NNS
cord-006439-q7m4srvp	210	2	of	of	IN
cord-006439-q7m4srvp	210	3	centrally	centrally	RB
cord-006439-q7m4srvp	210	4	administered	administer	VBN
cord-006439-q7m4srvp	210	5	losartan	losartan	NNP
cord-006439-q7m4srvp	210	6	on	on	IN
cord-006439-q7m4srvp	210	7	deoxycorticosterone	deoxycorticosterone	NNP
cord-006439-q7m4srvp	210	8	-	-	HYPH
cord-006439-q7m4srvp	210	9	salt	salt	NN
cord-006439-q7m4srvp	210	10	hypertension	hypertension	NN
cord-006439-q7m4srvp	210	11	rats	rat	NNS
cord-006439-q7m4srvp	210	12	DOCA	DOCA	NNP
cord-006439-q7m4srvp	210	13	-	-	HYPH
cord-006439-q7m4srvp	210	14	salt	salt	NN
cord-006439-q7m4srvp	210	15	hypertension	hypertension	NN
cord-006439-q7m4srvp	210	16	:	:	:
cord-006439-q7m4srvp	211	1	an	an	DT
cord-006439-q7m4srvp	211	2	update	update	NN
cord-006439-q7m4srvp	211	3	Neuron	Neuron	NNP
cord-006439-q7m4srvp	211	4	-	-	HYPH
cord-006439-q7m4srvp	211	5	specific	specific	JJ
cord-006439-q7m4srvp	211	6	(	(	-LRB-
cord-006439-q7m4srvp	211	7	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	211	8	receptor	receptor	NN
cord-006439-q7m4srvp	211	9	knockout	knockout	NN
cord-006439-q7m4srvp	211	10	prevents	prevent	VBZ
cord-006439-q7m4srvp	211	11	the	the	DT
cord-006439-q7m4srvp	211	12	development	development	NN
cord-006439-q7m4srvp	211	13	of	of	IN
cord-006439-q7m4srvp	211	14	salt	salt	NN
cord-006439-q7m4srvp	211	15	-	-	HYPH
cord-006439-q7m4srvp	211	16	sensitive	sensitive	JJ
cord-006439-q7m4srvp	211	17	hypertension	hypertension	NN
cord-006439-q7m4srvp	211	18	Neuronal	neuronal	JJ
cord-006439-q7m4srvp	211	19	(	(	-LRB-
cord-006439-q7m4srvp	211	20	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	211	21	receptor	receptor	NN
cord-006439-q7m4srvp	211	22	regulates	regulate	VBZ
cord-006439-q7m4srvp	211	23	deoxycorticosterone	deoxycorticosterone	NN
cord-006439-q7m4srvp	211	24	-	-	HYPH
cord-006439-q7m4srvp	211	25	induced	induce	VBN
cord-006439-q7m4srvp	211	26	sodium	sodium	NN
cord-006439-q7m4srvp	211	27	intake	intake	NN
cord-006439-q7m4srvp	211	28	Glutamatergic	Glutamatergic	NNP
cord-006439-q7m4srvp	211	29	neurons	neuron	NNS
cord-006439-q7m4srvp	211	30	of	of	IN
cord-006439-q7m4srvp	211	31	the	the	DT
cord-006439-q7m4srvp	211	32	paraventricular	paraventricular	NNP
cord-006439-q7m4srvp	211	33	nucleus	nucleus	NNP
cord-006439-q7m4srvp	211	34	are	be	VBP
cord-006439-q7m4srvp	211	35	critical	critical	JJ
cord-006439-q7m4srvp	211	36	contributors	contributor	NNS
cord-006439-q7m4srvp	211	37	to	to	IN
cord-006439-q7m4srvp	211	38	the	the	DT
cord-006439-q7m4srvp	211	39	development	development	NN
cord-006439-q7m4srvp	211	40	of	of	IN
cord-006439-q7m4srvp	211	41	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	211	42	hypertension	hypertension	NN
cord-006439-q7m4srvp	212	1	Direct	direct	JJ
cord-006439-q7m4srvp	212	2	pro	pro	JJ
cord-006439-q7m4srvp	212	3	-	-	JJ
cord-006439-q7m4srvp	212	4	inflammatory	inflammatory	JJ
cord-006439-q7m4srvp	212	5	effects	effect	NNS
cord-006439-q7m4srvp	212	6	of	of	IN
cord-006439-q7m4srvp	212	7	prorenin	prorenin	NN
cord-006439-q7m4srvp	212	8	on	on	IN
cord-006439-q7m4srvp	212	9	microglia	microglia	JJ
cord-006439-q7m4srvp	212	10	Soluble	soluble	JJ
cord-006439-q7m4srvp	212	11	form	form	NN
cord-006439-q7m4srvp	212	12	of	of	IN
cord-006439-q7m4srvp	212	13	the	the	DT
cord-006439-q7m4srvp	212	14	(	(	-LRB-
cord-006439-q7m4srvp	212	15	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	212	16	receptor	receptor	NN
cord-006439-q7m4srvp	212	17	generated	generate	VBN
cord-006439-q7m4srvp	212	18	by	by	IN
cord-006439-q7m4srvp	212	19	intracellular	intracellular	JJ
cord-006439-q7m4srvp	212	20	cleavage	cleavage	NN
cord-006439-q7m4srvp	212	21	by	by	IN
cord-006439-q7m4srvp	212	22	furin	furin	NN
cord-006439-q7m4srvp	212	23	is	be	VBZ
cord-006439-q7m4srvp	212	24	secreted	secrete	VBN
cord-006439-q7m4srvp	212	25	in	in	IN
cord-006439-q7m4srvp	212	26	plasma	plasma	NN
cord-006439-q7m4srvp	212	27	Site-1	Site-1	NNP
cord-006439-q7m4srvp	212	28	protease	protease	NN
cord-006439-q7m4srvp	212	29	is	be	VBZ
cord-006439-q7m4srvp	212	30	required	require	VBN
cord-006439-q7m4srvp	212	31	for	for	IN
cord-006439-q7m4srvp	212	32	the	the	DT
cord-006439-q7m4srvp	212	33	generation	generation	NN
cord-006439-q7m4srvp	212	34	of	of	IN
cord-006439-q7m4srvp	212	35	soluble	soluble	JJ
cord-006439-q7m4srvp	212	36	(	(	-LRB-
cord-006439-q7m4srvp	212	37	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	212	38	receptor	receptor	NN
cord-006439-q7m4srvp	212	39	Elevated	elevated	JJ
cord-006439-q7m4srvp	212	40	plasma	plasma	NN
cord-006439-q7m4srvp	212	41	levels	level	NNS
cord-006439-q7m4srvp	212	42	of	of	IN
cord-006439-q7m4srvp	212	43	soluble	soluble	JJ
cord-006439-q7m4srvp	212	44	(	(	-LRB-
cord-006439-q7m4srvp	212	45	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	212	46	receptor	receptor	NN
cord-006439-q7m4srvp	212	47	in	in	IN
cord-006439-q7m4srvp	212	48	patients	patient	NNS
cord-006439-q7m4srvp	212	49	with	with	IN
cord-006439-q7m4srvp	212	50	obstructive	obstructive	JJ
cord-006439-q7m4srvp	212	51	sleep	sleep	NN
cord-006439-q7m4srvp	212	52	apnea	apnea	NNP
cord-006439-q7m4srvp	212	53	syndrome	syndrome	NN
cord-006439-q7m4srvp	212	54	:	:	:
cord-006439-q7m4srvp	212	55	association	association	NNP
cord-006439-q7m4srvp	212	56	with	with	IN
cord-006439-q7m4srvp	212	57	polysomnographic	polysomnographic	JJ
cord-006439-q7m4srvp	212	58	parameters	parameter	NNS
cord-006439-q7m4srvp	212	59	Serum	serum	NN
cord-006439-q7m4srvp	212	60	level	level	NN
cord-006439-q7m4srvp	212	61	of	of	IN
cord-006439-q7m4srvp	212	62	soluble	soluble	JJ
cord-006439-q7m4srvp	212	63	(	(	-LRB-
cord-006439-q7m4srvp	212	64	pro)renin	pro)renin	RB
cord-006439-q7m4srvp	213	1	receptor	receptor	NN
cord-006439-q7m4srvp	213	2	is	be	VBZ
cord-006439-q7m4srvp	213	3	modulated	modulate	VBN
cord-006439-q7m4srvp	213	4	in	in	IN
cord-006439-q7m4srvp	213	5	chronic	chronic	JJ
cord-006439-q7m4srvp	213	6	kidney	kidney	NN
cord-006439-q7m4srvp	213	7	disease	disease	NN
cord-006439-q7m4srvp	213	8	Soluble	Soluble	NNP
cord-006439-q7m4srvp	213	9	(	(	-LRB-
cord-006439-q7m4srvp	213	10	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	213	11	receptor	receptor	NN
cord-006439-q7m4srvp	213	12	and	and	CC
cord-006439-q7m4srvp	213	13	blood	blood	NN
cord-006439-q7m4srvp	213	14	pressure	pressure	NN
cord-006439-q7m4srvp	213	15	during	during	IN
cord-006439-q7m4srvp	213	16	pregnancy	pregnancy	NN
cord-006439-q7m4srvp	213	17	:	:	:
cord-006439-q7m4srvp	214	1	a	a	DT
cord-006439-q7m4srvp	214	2	prospective	prospective	JJ
cord-006439-q7m4srvp	214	3	cohort	cohort	NN
cord-006439-q7m4srvp	214	4	study	study	NN
cord-006439-q7m4srvp	214	5	Serum	serum	NN
cord-006439-q7m4srvp	214	6	soluble	soluble	JJ
cord-006439-q7m4srvp	214	7	(	(	-LRB-
cord-006439-q7m4srvp	214	8	pro)renin	pro)renin	JJ
cord-006439-q7m4srvp	214	9	receptor	receptor	NN
cord-006439-q7m4srvp	214	10	levels	level	NNS
cord-006439-q7m4srvp	214	11	in	in	IN
cord-006439-q7m4srvp	214	12	patients	patient	NNS
cord-006439-q7m4srvp	214	13	with	with	IN
cord-006439-q7m4srvp	214	14	essential	essential	JJ
cord-006439-q7m4srvp	214	15	hypertension	hypertension	NN
cord-006439-q7m4srvp	214	16	Provides	provide	VBZ
cord-006439-q7m4srvp	214	17	key	key	JJ
cord-006439-q7m4srvp	214	18	evidence	evidence	NN
cord-006439-q7m4srvp	214	19	that	that	IN
cord-006439-q7m4srvp	214	20	soluble	soluble	JJ
cord-006439-q7m4srvp	214	21	prorenin	prorenin	JJ
cord-006439-q7m4srvp	214	22	receptor	receptor	NN
cord-006439-q7m4srvp	214	23	induces	induce	VBZ
cord-006439-q7m4srvp	214	24	blood	blood	NN
cord-006439-q7m4srvp	214	25	pressure	pressure	NN
cord-006439-q7m4srvp	214	26	elevation	elevation	NN
cord-006439-q7m4srvp	214	27	possibly	possibly	RB
cord-006439-q7m4srvp	214	28	through	through	IN
cord-006439-q7m4srvp	214	29	a	a	DT
cord-006439-q7m4srvp	214	30	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	214	31	mechanism	mechanism	NN
cord-006439-q7m4srvp	214	32	in	in	IN
cord-006439-q7m4srvp	214	33	diseases	disease	NNS
cord-006439-q7m4srvp	214	34	associated	associate	VBN
cord-006439-q7m4srvp	214	35	with	with	IN
cord-006439-q7m4srvp	214	36	obesity	obesity	NN
cord-006439-q7m4srvp	214	37	Losartan	Losartan	NNP
cord-006439-q7m4srvp	214	38	prevents	prevent	VBZ
cord-006439-q7m4srvp	214	39	the	the	DT
cord-006439-q7m4srvp	214	40	elevation	elevation	NN
cord-006439-q7m4srvp	214	41	of	of	IN
cord-006439-q7m4srvp	214	42	blood	blood	NN
cord-006439-q7m4srvp	214	43	pressure	pressure	NN
cord-006439-q7m4srvp	214	44	in	in	IN
cord-006439-q7m4srvp	214	45	adipose	adipose	JJ
cord-006439-q7m4srvp	214	46	-	-	HYPH
cord-006439-q7m4srvp	214	47	PRR	PRR	NNP
cord-006439-q7m4srvp	214	48	deficient	deficient	JJ
cord-006439-q7m4srvp	214	49	female	female	JJ
cord-006439-q7m4srvp	214	50	mice	mouse	NNS
cord-006439-q7m4srvp	214	51	while	while	IN
cord-006439-q7m4srvp	214	52	elevated	elevate	VBN
cord-006439-q7m4srvp	214	53	circulating	circulate	VBG
cord-006439-q7m4srvp	214	54	sPRR	sprr	NN
cord-006439-q7m4srvp	214	55	activates	activate	VBZ
cord-006439-q7m4srvp	214	56	the	the	DT
cord-006439-q7m4srvp	214	57	renin	renin	NN
cord-006439-q7m4srvp	214	58	-	-	HYPH
cord-006439-q7m4srvp	214	59	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	214	60	system	system	NN
cord-006439-q7m4srvp	214	61	Protective	protective	JJ
cord-006439-q7m4srvp	214	62	axis	axis	NN
cord-006439-q7m4srvp	214	63	of	of	IN
cord-006439-q7m4srvp	214	64	the	the	DT
cord-006439-q7m4srvp	214	65	renin	renin	NN
cord-006439-q7m4srvp	214	66	-	-	HYPH
cord-006439-q7m4srvp	214	67	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	214	68	system	system	NN
cord-006439-q7m4srvp	214	69	in	in	IN
cord-006439-q7m4srvp	214	70	the	the	DT
cord-006439-q7m4srvp	214	71	brain	brain	NN
cord-006439-q7m4srvp	214	72	Angiotensin-(1	Angiotensin-(1	NNP
cord-006439-q7m4srvp	214	73	-	-	HYPH
cord-006439-q7m4srvp	214	74	7	7	CD
cord-006439-q7m4srvp	214	75	)	)	-RRB-
cord-006439-q7m4srvp	214	76	is	be	VBZ
cord-006439-q7m4srvp	214	77	an	an	DT
cord-006439-q7m4srvp	214	78	endogenous	endogenous	JJ
cord-006439-q7m4srvp	214	79	ligand	ligand	NN
cord-006439-q7m4srvp	214	80	for	for	IN
cord-006439-q7m4srvp	214	81	the	the	DT
cord-006439-q7m4srvp	214	82	G	G	NNP
cord-006439-q7m4srvp	214	83	protein	protein	NN
cord-006439-q7m4srvp	214	84	-	-	HYPH
cord-006439-q7m4srvp	214	85	coupled	couple	VBN
cord-006439-q7m4srvp	214	86	receptor	receptor	NN
cord-006439-q7m4srvp	214	87	mas	mas	NNP
cord-006439-q7m4srvp	214	88	Evidence	evidence	NN
cord-006439-q7m4srvp	214	89	for	for	IN
cord-006439-q7m4srvp	214	90	heterodimerization	heterodimerization	NN
cord-006439-q7m4srvp	214	91	and	and	CC
cord-006439-q7m4srvp	214	92	functional	functional	JJ
cord-006439-q7m4srvp	214	93	interaction	interaction	NN
cord-006439-q7m4srvp	214	94	of	of	IN
cord-006439-q7m4srvp	214	95	the	the	DT
cord-006439-q7m4srvp	214	96	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	214	97	type	type	NN
cord-006439-q7m4srvp	214	98	2	2	CD
cord-006439-q7m4srvp	214	99	receptor	receptor	NN
cord-006439-q7m4srvp	214	100	and	and	CC
cord-006439-q7m4srvp	215	1	the	the	DT
cord-006439-q7m4srvp	215	2	receptor	receptor	NN
cord-006439-q7m4srvp	215	3	MAS	MAS	NNP
cord-006439-q7m4srvp	215	4	Ang-(1	Ang-(1	NNP
cord-006439-q7m4srvp	215	5	-	-	HYPH
cord-006439-q7m4srvp	215	6	7	7	NNP
cord-006439-q7m4srvp	215	7	)	)	-RRB-
cord-006439-q7m4srvp	215	8	is	be	VBZ
cord-006439-q7m4srvp	215	9	an	an	DT
cord-006439-q7m4srvp	215	10	endogenous	endogenous	JJ
cord-006439-q7m4srvp	215	11	betaarrestin	betaarrestin	NN
cord-006439-q7m4srvp	215	12	-	-	HYPH
cord-006439-q7m4srvp	215	13	biased	bias	VBN
cord-006439-q7m4srvp	215	14	agonist	agonist	NN
cord-006439-q7m4srvp	215	15	of	of	IN
cord-006439-q7m4srvp	215	16	the	the	DT
cord-006439-q7m4srvp	215	17	AT1	AT1	NNP
cord-006439-q7m4srvp	215	18	receptor	receptor	NN
cord-006439-q7m4srvp	215	19	with	with	IN
cord-006439-q7m4srvp	215	20	protective	protective	JJ
cord-006439-q7m4srvp	215	21	action	action	NN
cord-006439-q7m4srvp	215	22	in	in	IN
cord-006439-q7m4srvp	215	23	cardiac	cardiac	JJ
cord-006439-q7m4srvp	215	24	hypertrophy	hypertrophy	NN
cord-006439-q7m4srvp	215	25	Angiotensinconverting	Angiotensinconverting	NNP
cord-006439-q7m4srvp	215	26	enzyme	enzyme	NN
cord-006439-q7m4srvp	215	27	2	2	CD
cord-006439-q7m4srvp	215	28	,	,	,
cord-006439-q7m4srvp	215	29	angiotensin-(1	angiotensin-(1	CD
cord-006439-q7m4srvp	215	30	-	-	SYM
cord-006439-q7m4srvp	215	31	7	7	CD
cord-006439-q7m4srvp	215	32	)	)	-RRB-
cord-006439-q7m4srvp	215	33	and	and	CC
cord-006439-q7m4srvp	215	34	mas	mas	NNP
cord-006439-q7m4srvp	215	35	:	:	:
cord-006439-q7m4srvp	215	36	new	new	JJ
cord-006439-q7m4srvp	215	37	players	player	NNS
cord-006439-q7m4srvp	215	38	of	of	IN
cord-006439-q7m4srvp	215	39	the	the	DT
cord-006439-q7m4srvp	215	40	renin	renin	NN
cord-006439-q7m4srvp	215	41	-	-	HYPH
cord-006439-q7m4srvp	215	42	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	215	43	system	system	NN
cord-006439-q7m4srvp	215	44	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	215	45	II	II	NNP
cord-006439-q7m4srvp	215	46	type	type	NN
cord-006439-q7m4srvp	215	47	1	1	CD
cord-006439-q7m4srvp	215	48	receptor	receptor	NN
cord-006439-q7m4srvp	215	49	-	-	HYPH
cord-006439-q7m4srvp	215	50	mediated	mediate	VBN
cord-006439-q7m4srvp	215	51	reduction	reduction	NN
cord-006439-q7m4srvp	215	52	of	of	IN
cord-006439-q7m4srvp	215	53	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	215	54	-	-	HYPH
cord-006439-q7m4srvp	215	55	converting	convert	VBG
cord-006439-q7m4srvp	215	56	enzyme	enzyme	NN
cord-006439-q7m4srvp	215	57	2	2	CD
cord-006439-q7m4srvp	215	58	activity	activity	NN
cord-006439-q7m4srvp	215	59	in	in	IN
cord-006439-q7m4srvp	215	60	the	the	DT
cord-006439-q7m4srvp	215	61	brain	brain	NN
cord-006439-q7m4srvp	215	62	impairs	impair	VBZ
cord-006439-q7m4srvp	215	63	baroreflex	baroreflex	JJ
cord-006439-q7m4srvp	215	64	function	function	NN
cord-006439-q7m4srvp	215	65	in	in	IN
cord-006439-q7m4srvp	215	66	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	215	67	mice	mouse	NNS
cord-006439-q7m4srvp	215	68	Tumor	tumor	NN
cord-006439-q7m4srvp	215	69	necrosis	necrosis	NN
cord-006439-q7m4srvp	215	70	factor	factor	NN
cord-006439-q7m4srvp	215	71	-	-	HYPH
cord-006439-q7m4srvp	215	72	alpha	alpha	NN
cord-006439-q7m4srvp	215	73	convertase	convertase	NN
cord-006439-q7m4srvp	215	74	(	(	-LRB-
cord-006439-q7m4srvp	215	75	ADAM17	adam17	NN
cord-006439-q7m4srvp	215	76	)	)	-RRB-
cord-006439-q7m4srvp	216	1	mediates	mediate	VBZ
cord-006439-q7m4srvp	216	2	regulated	regulate	VBN
cord-006439-q7m4srvp	216	3	ectodomain	ectodomain	NN
cord-006439-q7m4srvp	216	4	shedding	shedding	NN
cord-006439-q7m4srvp	216	5	of	of	IN
cord-006439-q7m4srvp	216	6	the	the	DT
cord-006439-q7m4srvp	216	7	severe	severe	JJ
cord-006439-q7m4srvp	216	8	-	-	HYPH
cord-006439-q7m4srvp	216	9	acute	acute	JJ
cord-006439-q7m4srvp	216	10	respiratory	respiratory	JJ
cord-006439-q7m4srvp	216	11	syndrome	syndrome	NN
cord-006439-q7m4srvp	216	12	-	-	HYPH
cord-006439-q7m4srvp	216	13	coronavirus	coronavirus	NN
cord-006439-q7m4srvp	216	14	(	(	-LRB-
cord-006439-q7m4srvp	216	15	SARS	SARS	NNP
cord-006439-q7m4srvp	216	16	-	-	HYPH
cord-006439-q7m4srvp	216	17	CoV	CoV	NNP
cord-006439-q7m4srvp	216	18	)	)	-RRB-
cord-006439-q7m4srvp	216	19	receptor	receptor	NN
cord-006439-q7m4srvp	216	20	,	,	,
cord-006439-q7m4srvp	217	1	angiotensinconverting	angiotensinconverte	VBG
cord-006439-q7m4srvp	217	2	enzyme-2	enzyme-2	NNP
cord-006439-q7m4srvp	218	1	(	(	-LRB-
cord-006439-q7m4srvp	218	2	ACE2	ACE2	NNP
cord-006439-q7m4srvp	218	3	)	)	-RRB-
cord-006439-q7m4srvp	219	1	Brain	Brain	NNP
cord-006439-q7m4srvp	219	2	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	219	3	-	-	HYPH
cord-006439-q7m4srvp	219	4	converting	convert	VBG
cord-006439-q7m4srvp	219	5	enzyme	enzyme	NN
cord-006439-q7m4srvp	219	6	type	type	NN
cord-006439-q7m4srvp	219	7	2	2	CD
cord-006439-q7m4srvp	219	8	shedding	shedding	NN
cord-006439-q7m4srvp	219	9	contributes	contribute	VBZ
cord-006439-q7m4srvp	219	10	to	to	IN
cord-006439-q7m4srvp	219	11	the	the	DT
cord-006439-q7m4srvp	219	12	development	development	NN
cord-006439-q7m4srvp	219	13	of	of	IN
cord-006439-q7m4srvp	219	14	neurogenic	neurogenic	JJ
cord-006439-q7m4srvp	219	15	hypertension	hypertension	NN
cord-006439-q7m4srvp	219	16	Overexpression	Overexpression	NNP
cord-006439-q7m4srvp	219	17	of	of	IN
cord-006439-q7m4srvp	219	18	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	219	19	-	-	HYPH
cord-006439-q7m4srvp	219	20	converting	convert	VBG
cord-006439-q7m4srvp	219	21	enzyme	enzyme	NN
cord-006439-q7m4srvp	219	22	2	2	CD
cord-006439-q7m4srvp	219	23	in	in	IN
cord-006439-q7m4srvp	219	24	the	the	DT
cord-006439-q7m4srvp	219	25	rostral	rostral	JJ
cord-006439-q7m4srvp	219	26	ventrolateral	ventrolateral	JJ
cord-006439-q7m4srvp	219	27	medulla	medulla	NN
cord-006439-q7m4srvp	219	28	causes	cause	VBZ
cord-006439-q7m4srvp	219	29	long	long	JJ
cord-006439-q7m4srvp	219	30	-	-	HYPH
cord-006439-q7m4srvp	219	31	term	term	NN
cord-006439-q7m4srvp	219	32	decrease	decrease	NN
cord-006439-q7m4srvp	219	33	in	in	IN
cord-006439-q7m4srvp	219	34	blood	blood	NN
cord-006439-q7m4srvp	219	35	pressure	pressure	NN
cord-006439-q7m4srvp	219	36	in	in	IN
cord-006439-q7m4srvp	219	37	the	the	DT
cord-006439-q7m4srvp	219	38	spontaneously	spontaneously	RB
cord-006439-q7m4srvp	219	39	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	219	40	rats	rat	NNS
cord-006439-q7m4srvp	219	41	ACE2	ACE2	NNP
cord-006439-q7m4srvp	219	42	and	and	CC
cord-006439-q7m4srvp	219	43	ADAM17	ADAM17	NNP
cord-006439-q7m4srvp	219	44	interaction	interaction	NN
cord-006439-q7m4srvp	219	45	regulates	regulate	VBZ
cord-006439-q7m4srvp	219	46	the	the	DT
cord-006439-q7m4srvp	219	47	activity	activity	NN
cord-006439-q7m4srvp	219	48	of	of	IN
cord-006439-q7m4srvp	219	49	presympathetic	presympathetic	JJ
cord-006439-q7m4srvp	219	50	neurons	neuron	NNS
cord-006439-q7m4srvp	220	1	Stressinduced	stressinduced	JJ
cord-006439-q7m4srvp	220	2	sensitization	sensitization	NN
cord-006439-q7m4srvp	220	3	of	of	IN
cord-006439-q7m4srvp	220	4	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	220	5	II	II	NNP
cord-006439-q7m4srvp	220	6	hypertension	hypertension	NN
cord-006439-q7m4srvp	220	7	is	be	VBZ
cord-006439-q7m4srvp	220	8	reversed	reverse	VBN
cord-006439-q7m4srvp	220	9	by	by	IN
cord-006439-q7m4srvp	220	10	blockade	blockade	NN
cord-006439-q7m4srvp	220	11	of	of	IN
cord-006439-q7m4srvp	220	12	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	220	13	-	-	HYPH
cord-006439-q7m4srvp	220	14	converting	convert	VBG
cord-006439-q7m4srvp	220	15	enzyme	enzyme	NN
cord-006439-q7m4srvp	220	16	or	or	CC
cord-006439-q7m4srvp	220	17	tumor	tumor	NN
cord-006439-q7m4srvp	220	18	necrosis	necrosis	NN
cord-006439-q7m4srvp	220	19	factor	factor	NN
cord-006439-q7m4srvp	220	20	-	-	HYPH
cord-006439-q7m4srvp	220	21	alpha	alpha	NN
cord-006439-q7m4srvp	220	22	Central	central	JJ
cord-006439-q7m4srvp	220	23	inhibition	inhibition	NN
cord-006439-q7m4srvp	220	24	of	of	IN
cord-006439-q7m4srvp	220	25	tumor	tumor	NN
cord-006439-q7m4srvp	220	26	necrosis	necrosis	NN
cord-006439-q7m4srvp	220	27	factor	factor	NN
cord-006439-q7m4srvp	220	28	alpha	alpha	NN
cord-006439-q7m4srvp	220	29	reduces	reduce	VBZ
cord-006439-q7m4srvp	220	30	hypertension	hypertension	NN
cord-006439-q7m4srvp	220	31	by	by	IN
cord-006439-q7m4srvp	220	32	attenuating	attenuate	VBG
cord-006439-q7m4srvp	220	33	oxidative	oxidative	JJ
cord-006439-q7m4srvp	220	34	stress	stress	NN
cord-006439-q7m4srvp	220	35	in	in	IN
cord-006439-q7m4srvp	220	36	the	the	DT
cord-006439-q7m4srvp	220	37	rostral	rostral	JJ
cord-006439-q7m4srvp	220	38	ventrolateral	ventrolateral	JJ
cord-006439-q7m4srvp	220	39	medulla	medulla	NN
cord-006439-q7m4srvp	220	40	in	in	IN
cord-006439-q7m4srvp	220	41	renovascular	renovascular	JJ
cord-006439-q7m4srvp	220	42	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	220	43	rats	rat	NNS
cord-006439-q7m4srvp	220	44	Central	central	JJ
cord-006439-q7m4srvp	220	45	leptin	leptin	NN
cord-006439-q7m4srvp	220	46	and	and	CC
cord-006439-q7m4srvp	220	47	tumor	tumor	NN
cord-006439-q7m4srvp	220	48	necrosis	necrosis	NN
cord-006439-q7m4srvp	220	49	factor	factor	NN
cord-006439-q7m4srvp	220	50	-	-	HYPH
cord-006439-q7m4srvp	220	51	alpha	alpha	NN
cord-006439-q7m4srvp	220	52	(	(	-LRB-
cord-006439-q7m4srvp	220	53	TNFalpha	TNFalpha	NNP
cord-006439-q7m4srvp	220	54	)	)	-RRB-
cord-006439-q7m4srvp	220	55	in	in	IN
cord-006439-q7m4srvp	220	56	diurnal	diurnal	JJ
cord-006439-q7m4srvp	220	57	control	control	NN
cord-006439-q7m4srvp	220	58	of	of	IN
cord-006439-q7m4srvp	220	59	blood	blood	NN
cord-006439-q7m4srvp	220	60	pressure	pressure	NN
cord-006439-q7m4srvp	220	61	and	and	CC
cord-006439-q7m4srvp	220	62	hypertension	hypertension	NN
cord-006439-q7m4srvp	220	63	Diagnosis	diagnosis	NN
cord-006439-q7m4srvp	220	64	and	and	CC
cord-006439-q7m4srvp	220	65	treatment	treatment	NN
cord-006439-q7m4srvp	220	66	of	of	IN
cord-006439-q7m4srvp	220	67	low	low	JJ
cord-006439-q7m4srvp	220	68	-	-	HYPH
cord-006439-q7m4srvp	220	69	renin	renin	NN
cord-006439-q7m4srvp	220	70	hypertension	hypertension	NN
cord-006439-q7m4srvp	220	71	Angiotensinergic	Angiotensinergic	NNP
cord-006439-q7m4srvp	220	72	signaling	signal	VBG
cord-006439-q7m4srvp	220	73	in	in	IN
cord-006439-q7m4srvp	220	74	the	the	DT
cord-006439-q7m4srvp	220	75	brain	brain	NN
cord-006439-q7m4srvp	220	76	mediates	mediate	VBZ
cord-006439-q7m4srvp	220	77	metabolic	metabolic	JJ
cord-006439-q7m4srvp	220	78	effects	effect	NNS
cord-006439-q7m4srvp	220	79	of	of	IN
cord-006439-q7m4srvp	220	80	deoxycorticosterone	deoxycorticosterone	NNP
cord-006439-q7m4srvp	220	81	(	(	-LRB-
cord-006439-q7m4srvp	220	82	DOCA)-salt	DOCA)-salt	NNP
cord-006439-q7m4srvp	220	83	in	in	IN
cord-006439-q7m4srvp	220	84	C57	C57	NNP
cord-006439-q7m4srvp	220	85	mice	mouse	NNS
cord-006439-q7m4srvp	220	86	Aminopeptidase	Aminopeptidase	NNP
cord-006439-q7m4srvp	220	87	a	a	DT
cord-006439-q7m4srvp	220	88	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	220	89	as	as	IN
cord-006439-q7m4srvp	220	90	potential	potential	JJ
cord-006439-q7m4srvp	220	91	central	central	JJ
cord-006439-q7m4srvp	220	92	antihypertensive	antihypertensive	JJ
cord-006439-q7m4srvp	220	93	agents	agent	NNS
cord-006439-q7m4srvp	220	94	Brain	Brain	NNP
cord-006439-q7m4srvp	220	95	renin	renin	NN
cord-006439-q7m4srvp	220	96	-	-	HYPH
cord-006439-q7m4srvp	220	97	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	220	98	system	system	NN
cord-006439-q7m4srvp	220	99	blockade	blockade	NN
cord-006439-q7m4srvp	220	100	by	by	IN
cord-006439-q7m4srvp	220	101	systemically	systemically	RB
cord-006439-q7m4srvp	220	102	active	active	JJ
cord-006439-q7m4srvp	220	103	aminopeptidase	aminopeptidase	NN
cord-006439-q7m4srvp	220	104	a	a	DT
cord-006439-q7m4srvp	220	105	inhibitors	inhibitor	NNS
cord-006439-q7m4srvp	220	106	:	:	:
cord-006439-q7m4srvp	220	107	a	a	DT
cord-006439-q7m4srvp	220	108	potential	potential	JJ
cord-006439-q7m4srvp	220	109	treatment	treatment	NN
cord-006439-q7m4srvp	220	110	of	of	IN
cord-006439-q7m4srvp	220	111	salt	salt	NN
cord-006439-q7m4srvp	220	112	-	-	HYPH
cord-006439-q7m4srvp	220	113	dependent	dependent	JJ
cord-006439-q7m4srvp	220	114	hypertension	hypertension	NN
cord-006439-q7m4srvp	220	115	Efficacy	Efficacy	NNP
cord-006439-q7m4srvp	220	116	and	and	CC
cord-006439-q7m4srvp	220	117	safety	safety	NN
cord-006439-q7m4srvp	220	118	of	of	IN
cord-006439-q7m4srvp	220	119	firibastat	firibastat	NNP
cord-006439-q7m4srvp	220	120	,	,	,
cord-006439-q7m4srvp	220	121	a	a	DT
cord-006439-q7m4srvp	220	122	first	first	JJ
cord-006439-q7m4srvp	220	123	-	-	HYPH
cord-006439-q7m4srvp	220	124	in	in	IN
cord-006439-q7m4srvp	220	125	-	-	HYPH
cord-006439-q7m4srvp	220	126	class	class	NN
cord-006439-q7m4srvp	220	127	brain	brain	NN
cord-006439-q7m4srvp	220	128	aminopeptidase	aminopeptidase	NN
cord-006439-q7m4srvp	220	129	A	a	DT
cord-006439-q7m4srvp	220	130	inhibitor	inhibitor	NN
cord-006439-q7m4srvp	220	131	,	,	,
cord-006439-q7m4srvp	220	132	in	in	IN
cord-006439-q7m4srvp	220	133	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	220	134	overweight	overweight	JJ
cord-006439-q7m4srvp	220	135	patients	patient	NNS
cord-006439-q7m4srvp	220	136	of	of	IN
cord-006439-q7m4srvp	220	137	multiple	multiple	JJ
cord-006439-q7m4srvp	220	138	ethnic	ethnic	JJ
cord-006439-q7m4srvp	220	139	origins	origin	NNS
cord-006439-q7m4srvp	221	1	A	a	DT
cord-006439-q7m4srvp	221	2	pilot	pilot	NN
cord-006439-q7m4srvp	221	3	double	double	JJ
cord-006439-q7m4srvp	221	4	-	-	HYPH
cord-006439-q7m4srvp	221	5	blind	blind	JJ
cord-006439-q7m4srvp	221	6	randomized	randomized	JJ
cord-006439-q7m4srvp	221	7	placebo	placebo	NN
cord-006439-q7m4srvp	221	8	-	-	HYPH
cord-006439-q7m4srvp	221	9	controlled	control	VBN
cord-006439-q7m4srvp	221	10	crossover	crossover	NN
cord-006439-q7m4srvp	221	11	pharmacodynamic	pharmacodynamic	JJ
cord-006439-q7m4srvp	221	12	study	study	NN
cord-006439-q7m4srvp	221	13	of	of	IN
cord-006439-q7m4srvp	221	14	the	the	DT
cord-006439-q7m4srvp	221	15	centrally	centrally	RB
cord-006439-q7m4srvp	221	16	active	active	JJ
cord-006439-q7m4srvp	221	17	aminopeptidase	aminopeptidase	NN
cord-006439-q7m4srvp	221	18	A	a	DT
cord-006439-q7m4srvp	221	19	inhibitor	inhibitor	NN
cord-006439-q7m4srvp	221	20	,	,	,
cord-006439-q7m4srvp	221	21	firibastat	firibastat	JJ
cord-006439-q7m4srvp	221	22	,	,	,
cord-006439-q7m4srvp	221	23	in	in	IN
cord-006439-q7m4srvp	221	24	hypertension	hypertension	NN
cord-006439-q7m4srvp	221	25	NI956	NI956	NNP
cord-006439-q7m4srvp	221	26	/	/	SYM
cord-006439-q7m4srvp	221	27	QGC006	QGC006	NNP
cord-006439-q7m4srvp	221	28	,	,	,
cord-006439-q7m4srvp	221	29	a	a	DT
cord-006439-q7m4srvp	221	30	potent	potent	JJ
cord-006439-q7m4srvp	221	31	orally	orally	RB
cord-006439-q7m4srvp	221	32	active	active	JJ
cord-006439-q7m4srvp	221	33	,	,	,
cord-006439-q7m4srvp	221	34	brainpenetrating	brainpenetrate	VBG
cord-006439-q7m4srvp	221	35	aminopeptidase	aminopeptidase	NN
cord-006439-q7m4srvp	221	36	a	a	DT
cord-006439-q7m4srvp	221	37	inhibitor	inhibitor	NN
cord-006439-q7m4srvp	221	38	for	for	IN
cord-006439-q7m4srvp	221	39	treating	treat	VBG
cord-006439-q7m4srvp	221	40	hypertension	hypertension	NN
cord-006439-q7m4srvp	221	41	Attenuation	attenuation	NN
cord-006439-q7m4srvp	221	42	of	of	IN
cord-006439-q7m4srvp	221	43	stroke	stroke	NN
cord-006439-q7m4srvp	221	44	damage	damage	NN
cord-006439-q7m4srvp	221	45	by	by	IN
cord-006439-q7m4srvp	221	46	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	221	47	II	II	NNP
cord-006439-q7m4srvp	221	48	type	type	NN
cord-006439-q7m4srvp	221	49	2	2	CD
cord-006439-q7m4srvp	221	50	receptor	receptor	NN
cord-006439-q7m4srvp	221	51	stimulation	stimulation	NN
cord-006439-q7m4srvp	221	52	via	via	IN
cord-006439-q7m4srvp	221	53	peroxisome	peroxisome	NN
cord-006439-q7m4srvp	221	54	proliferator	proliferator	NN
cord-006439-q7m4srvp	221	55	-	-	HYPH
cord-006439-q7m4srvp	221	56	activated	activate	VBN
cord-006439-q7m4srvp	221	57	receptor	receptor	NN
cord-006439-q7m4srvp	221	58	-	-	HYPH
cord-006439-q7m4srvp	221	59	gamma	gamma	NN
cord-006439-q7m4srvp	221	60	activation	activation	NN
cord-006439-q7m4srvp	221	61	Protective	protective	JJ
cord-006439-q7m4srvp	221	62	effects	effect	NNS
cord-006439-q7m4srvp	221	63	of	of	IN
cord-006439-q7m4srvp	221	64	the	the	DT
cord-006439-q7m4srvp	221	65	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	221	66	II	II	NNP
cord-006439-q7m4srvp	221	67	AT2	at2	NN
cord-006439-q7m4srvp	221	68	receptor	receptor	NN
cord-006439-q7m4srvp	221	69	agonist	agonist	NN
cord-006439-q7m4srvp	221	70	compound	compound	NN
cord-006439-q7m4srvp	221	71	21	21	CD
cord-006439-q7m4srvp	221	72	in	in	IN
cord-006439-q7m4srvp	221	73	ischemic	ischemic	JJ
cord-006439-q7m4srvp	221	74	stroke	stroke	NN
cord-006439-q7m4srvp	221	75	:	:	:
cord-006439-q7m4srvp	221	76	a	a	DT
cord-006439-q7m4srvp	221	77	nose	nose	NN
cord-006439-q7m4srvp	221	78	-	-	HYPH
cord-006439-q7m4srvp	221	79	tobrain	tobrain	NN
cord-006439-q7m4srvp	221	80	delivery	delivery	NN
cord-006439-q7m4srvp	221	81	approach	approach	NN
cord-006439-q7m4srvp	221	82	Central	central	JJ
cord-006439-q7m4srvp	221	83	application	application	NN
cord-006439-q7m4srvp	221	84	of	of	IN
cord-006439-q7m4srvp	221	85	Aliskiren	Aliskiren	NNP
cord-006439-q7m4srvp	221	86	,	,	,
cord-006439-q7m4srvp	221	87	a	a	DT
cord-006439-q7m4srvp	221	88	renin	renin	NN
cord-006439-q7m4srvp	221	89	inhibitor	inhibitor	NN
cord-006439-q7m4srvp	221	90	,	,	,
cord-006439-q7m4srvp	221	91	improves	improve	VBZ
cord-006439-q7m4srvp	221	92	outcome	outcome	NN
cord-006439-q7m4srvp	221	93	after	after	IN
cord-006439-q7m4srvp	221	94	experimental	experimental	JJ
cord-006439-q7m4srvp	221	95	stroke	stroke	NN
cord-006439-q7m4srvp	221	96	independent	independent	JJ
cord-006439-q7m4srvp	221	97	of	of	IN
cord-006439-q7m4srvp	221	98	its	-PRON-	PRP$
cord-006439-q7m4srvp	221	99	blood	blood	NN
cord-006439-q7m4srvp	221	100	pressure	pressure	NN
cord-006439-q7m4srvp	221	101	lowering	lower	VBG
cord-006439-q7m4srvp	221	102	effect	effect	NN
cord-006439-q7m4srvp	222	1	Angiotensin	angiotensin	NN
cord-006439-q7m4srvp	222	2	-	-	HYPH
cord-006439-q7m4srvp	222	3	III	III	NNP
cord-006439-q7m4srvp	222	4	is	be	VBZ
cord-006439-q7m4srvp	222	5	increased	increase	VBN
cord-006439-q7m4srvp	222	6	in	in	IN
cord-006439-q7m4srvp	222	7	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	222	8	's	's	POS
cord-006439-q7m4srvp	222	9	disease	disease	NN
cord-006439-q7m4srvp	222	10	in	in	IN
cord-006439-q7m4srvp	222	11	association	association	NNP
cord-006439-q7m4srvp	222	12	with	with	IN
cord-006439-q7m4srvp	222	13	amyloidbeta	amyloidbeta	NNP
cord-006439-q7m4srvp	222	14	and	and	CC
cord-006439-q7m4srvp	222	15	tau	tau	NN
cord-006439-q7m4srvp	222	16	pathology	pathology	NN
cord-006439-q7m4srvp	223	1	Pleiotropic	Pleiotropic	NNP
cord-006439-q7m4srvp	223	2	benefits	benefit	NNS
cord-006439-q7m4srvp	223	3	of	of	IN
cord-006439-q7m4srvp	223	4	the	the	DT
cord-006439-q7m4srvp	223	5	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	223	6	receptor	receptor	NN
cord-006439-q7m4srvp	223	7	blocker	blocker	NN
cord-006439-q7m4srvp	223	8	candesartan	candesartan	NNP
cord-006439-q7m4srvp	223	9	in	in	IN
cord-006439-q7m4srvp	223	10	a	a	DT
cord-006439-q7m4srvp	223	11	mouse	mouse	NN
cord-006439-q7m4srvp	223	12	model	model	NN
cord-006439-q7m4srvp	223	13	of	of	IN
cord-006439-q7m4srvp	223	14	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	223	15	disease	disease	NN
cord-006439-q7m4srvp	224	1	An	an	DT
cord-006439-q7m4srvp	224	2	integrative	integrative	JJ
cord-006439-q7m4srvp	224	3	genomewide	genomewide	NNP
cord-006439-q7m4srvp	224	4	transcriptome	transcriptome	NN
cord-006439-q7m4srvp	224	5	reveals	reveal	VBZ
cord-006439-q7m4srvp	224	6	that	that	IN
cord-006439-q7m4srvp	224	7	candesartan	candesartan	NNP
cord-006439-q7m4srvp	224	8	is	be	VBZ
cord-006439-q7m4srvp	224	9	neuroprotective	neuroprotective	JJ
cord-006439-q7m4srvp	224	10	and	and	CC
cord-006439-q7m4srvp	224	11	a	a	DT
cord-006439-q7m4srvp	224	12	candidate	candidate	NN
cord-006439-q7m4srvp	224	13	therapeutic	therapeutic	JJ
cord-006439-q7m4srvp	224	14	for	for	IN
cord-006439-q7m4srvp	224	15	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	224	16	's	's	POS
cord-006439-q7m4srvp	224	17	disease	disease	NN
cord-006439-q7m4srvp	224	18	Memory	memory	NN
cord-006439-q7m4srvp	224	19	is	be	VBZ
cord-006439-q7m4srvp	224	20	preserved	preserve	VBN
cord-006439-q7m4srvp	224	21	in	in	IN
cord-006439-q7m4srvp	224	22	older	old	JJR
cord-006439-q7m4srvp	224	23	adults	adult	NNS
cord-006439-q7m4srvp	224	24	taking	take	VBG
cord-006439-q7m4srvp	224	25	AT1	at1	NN
cord-006439-q7m4srvp	224	26	receptor	receptor	NN
cord-006439-q7m4srvp	224	27	blockers	blocker	NNS
cord-006439-q7m4srvp	224	28	Cognitive	cognitive	JJ
cord-006439-q7m4srvp	224	29	benefits	benefit	NNS
cord-006439-q7m4srvp	224	30	of	of	IN
cord-006439-q7m4srvp	224	31	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	224	32	IV	IV	NNP
cord-006439-q7m4srvp	224	33	and	and	CC
cord-006439-q7m4srvp	224	34	angiotensin-(1	angiotensin-(1	CD
cord-006439-q7m4srvp	224	35	-	-	SYM
cord-006439-q7m4srvp	224	36	7	7	CD
cord-006439-q7m4srvp	224	37	)	)	-RRB-
cord-006439-q7m4srvp	224	38	:	:	:
cord-006439-q7m4srvp	224	39	a	a	DT
cord-006439-q7m4srvp	224	40	systematic	systematic	JJ
cord-006439-q7m4srvp	224	41	review	review	NN
cord-006439-q7m4srvp	224	42	of	of	IN
cord-006439-q7m4srvp	224	43	experimental	experimental	JJ
cord-006439-q7m4srvp	224	44	studies	study	NNS
cord-006439-q7m4srvp	224	45	Angiotensin	Angiotensin	NNP
cord-006439-q7m4srvp	224	46	II	II	NNP
cord-006439-q7m4srvp	224	47	-	-	:
cord-006439-q7m4srvp	224	48	and	and	CC
cord-006439-q7m4srvp	224	49	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	224	50	-	-	HYPH
cord-006439-q7m4srvp	224	51	type	type	NN
cord-006439-q7m4srvp	224	52	cardiovascular	cardiovascular	JJ
cord-006439-q7m4srvp	224	53	aging	age	VBG
cord-006439-q7m4srvp	224	54	Central	central	JJ
cord-006439-q7m4srvp	224	55	administration	administration	NN
cord-006439-q7m4srvp	224	56	of	of	IN
cord-006439-q7m4srvp	224	57	TRV027	TRV027	NNP
cord-006439-q7m4srvp	224	58	improves	improve	VBZ
cord-006439-q7m4srvp	224	59	baroreflex	baroreflex	NN
cord-006439-q7m4srvp	224	60	sensitivity	sensitivity	NN
cord-006439-q7m4srvp	224	61	and	and	CC
cord-006439-q7m4srvp	224	62	vascular	vascular	JJ
cord-006439-q7m4srvp	224	63	reactivity	reactivity	NN
cord-006439-q7m4srvp	224	64	in	in	IN
cord-006439-q7m4srvp	224	65	spontaneously	spontaneously	RB
cord-006439-q7m4srvp	224	66	hypertensive	hypertensive	JJ
cord-006439-q7m4srvp	224	67	rats	rat	NNS
cord-006439-q7m4srvp	225	1	Intranasal	Intranasal	NNP
cord-006439-q7m4srvp	225	2	telmisartan	telmisartan	NNP
cord-006439-q7m4srvp	225	3	ameliorates	ameliorate	VBZ
cord-006439-q7m4srvp	225	4	brain	brain	NN
cord-006439-q7m4srvp	225	5	pathology	pathology	NN
cord-006439-q7m4srvp	225	6	in	in	IN
cord-006439-q7m4srvp	225	7	five	five	CD
cord-006439-q7m4srvp	225	8	familial	familial	JJ
cord-006439-q7m4srvp	225	9	Alzheimer	Alzheimer	NNP
cord-006439-q7m4srvp	225	10	's	's	POS
cord-006439-q7m4srvp	225	11	disease	disease	NN
cord-006439-q7m4srvp	225	12	mice	mouse	NNS
cord-006439-q7m4srvp	225	13	Distribution	distribution	NN
cord-006439-q7m4srvp	225	14	of	of	IN
cord-006439-q7m4srvp	225	15	angiotensin	angiotensin	NN
cord-006439-q7m4srvp	225	16	type	type	NN
cord-006439-q7m4srvp	225	17	1a	1a	CD
cord-006439-q7m4srvp	225	18	receptorcontaining	receptorcontaining	NN
cord-006439-q7m4srvp	225	19	cells	cell	NNS
cord-006439-q7m4srvp	225	20	in	in	IN
cord-006439-q7m4srvp	225	21	the	the	DT
cord-006439-q7m4srvp	225	22	brains	brain	NNS
cord-006439-q7m4srvp	225	23	of	of	IN
cord-006439-q7m4srvp	225	24	bacterial	bacterial	JJ
cord-006439-q7m4srvp	225	25	artificial	artificial	JJ
cord-006439-q7m4srvp	225	26	chromosome	chromosome	NN
cord-006439-q7m4srvp	225	27	transgenic	transgenic	JJ
cord-006439-q7m4srvp	225	28	mice	mouse	NNS
cord-006439-q7m4srvp	226	1	Renin	renin	NN
cord-006439-q7m4srvp	226	2	cells	cell	NNS
cord-006439-q7m4srvp	226	3	are	be	VBP
cord-006439-q7m4srvp	226	4	precursors	precursor	NNS
cord-006439-q7m4srvp	226	5	for	for	IN
cord-006439-q7m4srvp	226	6	multiple	multiple	JJ
cord-006439-q7m4srvp	226	7	cell	cell	NN
cord-006439-q7m4srvp	226	8	types	type	NNS
cord-006439-q7m4srvp	226	9	that	that	WDT
cord-006439-q7m4srvp	226	10	switch	switch	VBP
cord-006439-q7m4srvp	226	11	to	to	IN
cord-006439-q7m4srvp	226	12	the	the	DT
cord-006439-q7m4srvp	226	13	renin	renin	NN
cord-006439-q7m4srvp	226	14	phenotype	phenotype	NN
cord-006439-q7m4srvp	226	15	when	when	WRB
cord-006439-q7m4srvp	226	16	homeostasis	homeostasis	NN
cord-006439-q7m4srvp	226	17	is	be	VBZ
cord-006439-q7m4srvp	226	18	threatened	threaten	VBN
cord-006439-q7m4srvp	226	19	Demonstrated	demonstrate	VBN
cord-006439-q7m4srvp	226	20	that	that	IN
cord-006439-q7m4srvp	226	21	DREADD	DREADD	NNP
cord-006439-q7m4srvp	226	22	-	-	HYPH
cord-006439-q7m4srvp	226	23	mediated	mediate	VBN
cord-006439-q7m4srvp	226	24	stimulation	stimulation	NN
cord-006439-q7m4srvp	226	25	of	of	IN
cord-006439-q7m4srvp	226	26	neurons	neuron	NNS
cord-006439-q7m4srvp	226	27	within	within	IN
cord-006439-q7m4srvp	226	28	the	the	DT
cord-006439-q7m4srvp	226	29	subfornical	subfornical	JJ
cord-006439-q7m4srvp	226	30	organ	organ	NN
cord-006439-q7m4srvp	226	31	leads	lead	VBZ
cord-006439-q7m4srvp	226	32	to	to	IN
cord-006439-q7m4srvp	226	33	prominent	prominent	JJ
cord-006439-q7m4srvp	226	34	dipsogenic	dipsogenic	JJ
cord-006439-q7m4srvp	226	35	responses	response	NNS
cord-006439-q7m4srvp	226	36	and	and	CC
cord-006439-q7m4srvp	226	37	salt	salt	NN
cord-006439-q7m4srvp	226	38	appetite	appetite	NN
cord-006439-q7m4srvp	226	39	In	in	IN
cord-006439-q7m4srvp	226	40	silico	silico	NN
cord-006439-q7m4srvp	226	41	re	re	NN
cord-006439-q7m4srvp	226	42	-	-	NN
cord-006439-q7m4srvp	226	43	analysis	analysis	NN
cord-006439-q7m4srvp	226	44	of	of	IN
cord-006439-q7m4srvp	226	45	hypothalamic	hypothalamic	JJ
cord-006439-q7m4srvp	226	46	single	single	JJ
cord-006439-q7m4srvp	226	47	-	-	HYPH
cord-006439-q7m4srvp	226	48	cell	cell	NN
cord-006439-q7m4srvp	226	49	RNA	rna	NN
cord-006439-q7m4srvp	226	50	sequencing	sequencing	NN
cord-006439-q7m4srvp	226	51	datasets	dataset	NNS
cord-006439-q7m4srvp	226	52	reveals	reveal	VBZ
cord-006439-q7m4srvp	226	53	that	that	IN
cord-006439-q7m4srvp	226	54	AT	AT	NNP
cord-006439-q7m4srvp	226	55	1	1	CD
cord-006439-q7m4srvp	226	56	R	r	NN
cord-006439-q7m4srvp	226	57	is	be	VBZ
cord-006439-q7m4srvp	226	58	expressed	express	VBN
cord-006439-q7m4srvp	226	59	in	in	IN
cord-006439-q7m4srvp	226	60	a	a	DT
cord-006439-q7m4srvp	226	61	specific	specific	JJ
cord-006439-q7m4srvp	226	62	subcluster	subcluster	NN
cord-006439-q7m4srvp	226	63	of	of	IN
cord-006439-q7m4srvp	226	64	neurons	neuron	NNS
cord-006439-q7m4srvp	226	65	expressing	express	VBG
cord-006439-q7m4srvp	226	66	both	both	DT
cord-006439-q7m4srvp	226	67	Agouti	Agouti	NNP
cord-006439-q7m4srvp	226	68	-	-	HYPH
cord-006439-q7m4srvp	226	69	related	relate	VBN
cord-006439-q7m4srvp	226	70	peptide	peptide	NN
cord-006439-q7m4srvp	226	71	(	(	-LRB-
cord-006439-q7m4srvp	226	72	AgRP	AgRP	NNP
cord-006439-q7m4srvp	226	73	)	)	-RRB-
cord-006439-q7m4srvp	226	74	and	and	CC
cord-006439-q7m4srvp	226	75	leptin	leptin	NN
cord-006439-q7m4srvp	226	76	receptors	receptor	NNS
cord-006439-q7m4srvp	227	1	Publisher	publisher	NN
cord-006439-q7m4srvp	227	2	's	's	POS
cord-006439-q7m4srvp	227	3	Note	Note	NNP
cord-006439-q7m4srvp	227	4	Springer	Springer	NNP
cord-006439-q7m4srvp	227	5	Nature	Nature	NNP
cord-006439-q7m4srvp	227	6	remains	remain	VBZ
cord-006439-q7m4srvp	227	7	neutral	neutral	JJ
cord-006439-q7m4srvp	227	8	with	with	IN
cord-006439-q7m4srvp	227	9	regard	regard	NN
cord-006439-q7m4srvp	227	10	to	to	IN
cord-006439-q7m4srvp	227	11	jurisdictional	jurisdictional	JJ
cord-006439-q7m4srvp	227	12	claims	claim	NNS
cord-006439-q7m4srvp	227	13	in	in	IN
cord-006439-q7m4srvp	227	14	published	publish	VBN
cord-006439-q7m4srvp	227	15	maps	map	NNS
cord-006439-q7m4srvp	227	16	and	and	CC
cord-006439-q7m4srvp	227	17	institutional	institutional	JJ
cord-006439-q7m4srvp	227	18	affiliations	affiliation	NNS