id	sid	tid	token	lemma	pos
cord-257558-dgnbfzli	1	1	key	key	JJ
cord-257558-dgnbfzli	1	2	:	:	:
cord-257558-dgnbfzli	1	3	cord-257558-dgnbfzli	cord-257558-dgnbfzli	ADD
cord-257558-dgnbfzli	1	4	authors	author	NNS
cord-257558-dgnbfzli	1	5	:	:	:
cord-257558-dgnbfzli	1	6	Diamond	Diamond	NNP
cord-257558-dgnbfzli	1	7	,	,	,
cord-257558-dgnbfzli	1	8	Betty	Betty	NNP
cord-257558-dgnbfzli	1	9	title	title	NN
cord-257558-dgnbfzli	1	10	:	:	:
cord-257558-dgnbfzli	1	11	The	the	DT
cord-257558-dgnbfzli	1	12	renin	renin	NN
cord-257558-dgnbfzli	1	13	–	–	:
cord-257558-dgnbfzli	1	14	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	1	15	system	system	NN
cord-257558-dgnbfzli	1	16	:	:	:
cord-257558-dgnbfzli	2	1	An	an	DT
cord-257558-dgnbfzli	2	2	integrated	integrated	JJ
cord-257558-dgnbfzli	2	3	view	view	NN
cord-257558-dgnbfzli	2	4	of	of	IN
cord-257558-dgnbfzli	2	5	lung	lung	NN
cord-257558-dgnbfzli	2	6	disease	disease	NN
cord-257558-dgnbfzli	2	7	and	and	CC
cord-257558-dgnbfzli	2	8	coagulopathy	coagulopathy	NN
cord-257558-dgnbfzli	2	9	in	in	IN
cord-257558-dgnbfzli	2	10	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	2	11	and	and	CC
cord-257558-dgnbfzli	2	12	therapeutic	therapeutic	JJ
cord-257558-dgnbfzli	2	13	implications	implication	NNS
cord-257558-dgnbfzli	2	14	date	date	NN
cord-257558-dgnbfzli	2	15	:	:	:
cord-257558-dgnbfzli	2	16	2020	2020	CD
cord-257558-dgnbfzli	2	17	-	-	HYPH
cord-257558-dgnbfzli	2	18	06	06	CD
cord-257558-dgnbfzli	2	19	-	-	SYM
cord-257558-dgnbfzli	2	20	18	18	CD
cord-257558-dgnbfzli	2	21	journal	journal	NN
cord-257558-dgnbfzli	2	22	:	:	:
cord-257558-dgnbfzli	3	1	J	J	NNP
cord-257558-dgnbfzli	3	2	Exp	Exp	NNP
cord-257558-dgnbfzli	3	3	Med	Med	NNP
cord-257558-dgnbfzli	3	4	DOI	DOI	NNP
cord-257558-dgnbfzli	3	5	:	:	:
cord-257558-dgnbfzli	3	6	10.1084	10.1084	CD
cord-257558-dgnbfzli	3	7	/	/	SYM
cord-257558-dgnbfzli	3	8	jem.20201000	jem.20201000	NNP
cord-257558-dgnbfzli	3	9	sha	sha	NNP
cord-257558-dgnbfzli	3	10	:	:	:
cord-257558-dgnbfzli	3	11	0a9b4684df9c21787c85d3c6cb39b3b877d9ba4f	0a9b4684df9c21787c85d3c6cb39b3b877d9ba4f	CD
cord-257558-dgnbfzli	4	1	doc_id	doc_id	CD
cord-257558-dgnbfzli	4	2	:	:	:
cord-257558-dgnbfzli	4	3	257558	257558	CD
cord-257558-dgnbfzli	4	4	cord_uid	cord_uid	NNS
cord-257558-dgnbfzli	4	5	:	:	:
cord-257558-dgnbfzli	4	6	dgnbfzli	dgnbfzli	VB
cord-257558-dgnbfzli	4	7	The	the	DT
cord-257558-dgnbfzli	4	8	renin	renin	NN
cord-257558-dgnbfzli	4	9	–	–	:
cord-257558-dgnbfzli	4	10	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	4	11	system	system	NN
cord-257558-dgnbfzli	4	12	(	(	-LRB-
cord-257558-dgnbfzli	4	13	RAS	RAS	NNP
cord-257558-dgnbfzli	4	14	)	)	-RRB-
cord-257558-dgnbfzli	4	15	has	have	VBZ
cord-257558-dgnbfzli	4	16	long	long	RB
cord-257558-dgnbfzli	4	17	been	be	VBN
cord-257558-dgnbfzli	4	18	appreciated	appreciate	VBN
cord-257558-dgnbfzli	4	19	as	as	IN
cord-257558-dgnbfzli	4	20	a	a	DT
cord-257558-dgnbfzli	4	21	major	major	JJ
cord-257558-dgnbfzli	4	22	regulator	regulator	NN
cord-257558-dgnbfzli	4	23	of	of	IN
cord-257558-dgnbfzli	4	24	blood	blood	NN
cord-257558-dgnbfzli	4	25	pressure	pressure	NN
cord-257558-dgnbfzli	4	26	,	,	,
cord-257558-dgnbfzli	4	27	but	but	CC
cord-257558-dgnbfzli	4	28	has	have	VBZ
cord-257558-dgnbfzli	4	29	more	more	RBR
cord-257558-dgnbfzli	4	30	recently	recently	RB
cord-257558-dgnbfzli	4	31	been	be	VBN
cord-257558-dgnbfzli	4	32	recognized	recognize	VBN
cord-257558-dgnbfzli	4	33	as	as	IN
cord-257558-dgnbfzli	4	34	a	a	DT
cord-257558-dgnbfzli	4	35	mechanism	mechanism	NN
cord-257558-dgnbfzli	4	36	for	for	IN
cord-257558-dgnbfzli	4	37	modulating	modulate	VBG
cord-257558-dgnbfzli	4	38	inflammation	inflammation	NN
cord-257558-dgnbfzli	4	39	as	as	RB
cord-257558-dgnbfzli	4	40	well	well	RB
cord-257558-dgnbfzli	4	41	.	.	.
cord-257558-dgnbfzli	5	1	While	while	IN
cord-257558-dgnbfzli	5	2	there	there	EX
cord-257558-dgnbfzli	5	3	has	have	VBZ
cord-257558-dgnbfzli	5	4	been	be	VBN
cord-257558-dgnbfzli	5	5	concern	concern	NN
cord-257558-dgnbfzli	5	6	in	in	IN
cord-257558-dgnbfzli	5	7	COVID-19	covid-19	JJ
cord-257558-dgnbfzli	5	8	patients	patient	NNS
cord-257558-dgnbfzli	5	9	over	over	IN
cord-257558-dgnbfzli	5	10	the	the	DT
cord-257558-dgnbfzli	5	11	use	use	NN
cord-257558-dgnbfzli	5	12	of	of	IN
cord-257558-dgnbfzli	5	13	drugs	drug	NNS
cord-257558-dgnbfzli	5	14	that	that	WDT
cord-257558-dgnbfzli	5	15	target	target	VBP
cord-257558-dgnbfzli	5	16	this	this	DT
cord-257558-dgnbfzli	5	17	system	system	NN
cord-257558-dgnbfzli	5	18	,	,	,
cord-257558-dgnbfzli	5	19	the	the	DT
cord-257558-dgnbfzli	5	20	RAS	RAS	NNP
cord-257558-dgnbfzli	5	21	has	have	VBZ
cord-257558-dgnbfzli	5	22	not	not	RB
cord-257558-dgnbfzli	5	23	been	be	VBN
cord-257558-dgnbfzli	5	24	explored	explore	VBN
cord-257558-dgnbfzli	5	25	fully	fully	RB
cord-257558-dgnbfzli	5	26	as	as	IN
cord-257558-dgnbfzli	5	27	a	a	DT
cord-257558-dgnbfzli	5	28	druggable	druggable	JJ
cord-257558-dgnbfzli	5	29	target	target	NN
cord-257558-dgnbfzli	5	30	.	.	.
cord-257558-dgnbfzli	6	1	The	the	DT
cord-257558-dgnbfzli	6	2	abbreviated	abbreviated	JJ
cord-257558-dgnbfzli	6	3	description	description	NN
cord-257558-dgnbfzli	6	4	of	of	IN
cord-257558-dgnbfzli	6	5	the	the	DT
cord-257558-dgnbfzli	6	6	RAS	RAS	NNP
cord-257558-dgnbfzli	6	7	suggests	suggest	VBZ
cord-257558-dgnbfzli	6	8	that	that	IN
cord-257558-dgnbfzli	6	9	its	-PRON-	PRP$
cord-257558-dgnbfzli	6	10	dysregulation	dysregulation	NN
cord-257558-dgnbfzli	6	11	may	may	MD
cord-257558-dgnbfzli	6	12	be	be	VB
cord-257558-dgnbfzli	6	13	at	at	IN
cord-257558-dgnbfzli	6	14	the	the	DT
cord-257558-dgnbfzli	6	15	center	center	NN
cord-257558-dgnbfzli	6	16	of	of	IN
cord-257558-dgnbfzli	6	17	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	6	18	.	.	.
cord-257558-dgnbfzli	7	1	Engagement	engagement	NN
cord-257558-dgnbfzli	7	2	of	of	IN
cord-257558-dgnbfzli	7	3	the	the	DT
cord-257558-dgnbfzli	7	4	second	second	JJ
cord-257558-dgnbfzli	7	5	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	7	6	receptor	receptor	NN
cord-257558-dgnbfzli	7	7	,	,	,
cord-257558-dgnbfzli	7	8	AT2	at2	NN
cord-257558-dgnbfzli	7	9	,	,	,
cord-257558-dgnbfzli	7	10	also	also	RB
cord-257558-dgnbfzli	7	11	expressed	express	VBD
cord-257558-dgnbfzli	7	12	fairly	fairly	RB
cord-257558-dgnbfzli	7	13	ubiquitously	ubiquitously	RB
cord-257558-dgnbfzli	7	14	,	,	,
cord-257558-dgnbfzli	7	15	by	by	IN
cord-257558-dgnbfzli	7	16	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	7	17	II	II	NNP
cord-257558-dgnbfzli	7	18	leads	lead	VBZ
cord-257558-dgnbfzli	7	19	to	to	IN
cord-257558-dgnbfzli	7	20	vasodilation	vasodilation	NN
cord-257558-dgnbfzli	7	21	and	and	CC
cord-257558-dgnbfzli	7	22	to	to	IN
cord-257558-dgnbfzli	7	23	suppression	suppression	NN
cord-257558-dgnbfzli	7	24	of	of	IN
cord-257558-dgnbfzli	7	25	inflammation	inflammation	NN
cord-257558-dgnbfzli	7	26	(	(	-LRB-
cord-257558-dgnbfzli	7	27	Crowley	Crowley	NNP
cord-257558-dgnbfzli	7	28	and	and	CC
cord-257558-dgnbfzli	7	29	Rudemiller	Rudemiller	NNP
cord-257558-dgnbfzli	7	30	,	,	,
cord-257558-dgnbfzli	7	31	2017	2017	CD
cord-257558-dgnbfzli	7	32	)	)	-RRB-
cord-257558-dgnbfzli	7	33	.	.	.
cord-257558-dgnbfzli	8	1	Under	under	IN
cord-257558-dgnbfzli	8	2	both	both	DT
cord-257558-dgnbfzli	8	3	acute	acute	JJ
cord-257558-dgnbfzli	8	4	and	and	CC
cord-257558-dgnbfzli	8	5	chronic	chronic	JJ
cord-257558-dgnbfzli	8	6	inflammatory	inflammatory	JJ
cord-257558-dgnbfzli	8	7	conditions	condition	NNS
cord-257558-dgnbfzli	8	8	,	,	,
cord-257558-dgnbfzli	8	9	the	the	DT
cord-257558-dgnbfzli	8	10	level	level	NN
cord-257558-dgnbfzli	8	11	of	of	IN
cord-257558-dgnbfzli	8	12	AT1	at1	NN
cord-257558-dgnbfzli	8	13	is	be	VBZ
cord-257558-dgnbfzli	8	14	increased	increase	VBN
cord-257558-dgnbfzli	8	15	and	and	CC
cord-257558-dgnbfzli	8	16	the	the	DT
cord-257558-dgnbfzli	8	17	level	level	NN
cord-257558-dgnbfzli	8	18	of	of	IN
cord-257558-dgnbfzli	8	19	AT2	at2	NN
cord-257558-dgnbfzli	8	20	is	be	VBZ
cord-257558-dgnbfzli	8	21	decreased	decrease	VBN
cord-257558-dgnbfzli	8	22	(	(	-LRB-
cord-257558-dgnbfzli	8	23	Crowley	Crowley	NNP
cord-257558-dgnbfzli	8	24	and	and	CC
cord-257558-dgnbfzli	8	25	Rudemiller	Rudemiller	NNP
cord-257558-dgnbfzli	8	26	,	,	,
cord-257558-dgnbfzli	8	27	2017	2017	CD
cord-257558-dgnbfzli	8	28	;	;	:
cord-257558-dgnbfzli	8	29	Koka	Koka	NNP
cord-257558-dgnbfzli	8	30	et	et	NNP
cord-257558-dgnbfzli	8	31	al	al	NNP
cord-257558-dgnbfzli	8	32	.	.	NNP
cord-257558-dgnbfzli	8	33	,	,	,
cord-257558-dgnbfzli	8	34	2008	2008	CD
cord-257558-dgnbfzli	8	35	;	;	.
cord-257558-dgnbfzli	9	1	Tikellis	Tikellis	NNP
cord-257558-dgnbfzli	9	2	and	and	CC
cord-257558-dgnbfzli	9	3	Thomas	Thomas	NNP
cord-257558-dgnbfzli	9	4	,	,	,
cord-257558-dgnbfzli	9	5	2012	2012	CD
cord-257558-dgnbfzli	9	6	)	)	-RRB-
cord-257558-dgnbfzli	9	7	.	.	.
cord-257558-dgnbfzli	10	1	A	a	DT
cord-257558-dgnbfzli	10	2	second	second	JJ
cord-257558-dgnbfzli	10	3	ACE	ace	NN
cord-257558-dgnbfzli	10	4	,	,	,
cord-257558-dgnbfzli	10	5	ACE2	ACE2	NNP
cord-257558-dgnbfzli	10	6	,	,	,
cord-257558-dgnbfzli	10	7	exists	exist	VBZ
cord-257558-dgnbfzli	10	8	as	as	IN
cord-257558-dgnbfzli	10	9	a	a	DT
cord-257558-dgnbfzli	10	10	membrane	membrane	NN
cord-257558-dgnbfzli	10	11	-	-	HYPH
cord-257558-dgnbfzli	10	12	bound	bind	VBN
cord-257558-dgnbfzli	10	13	protease	protease	NN
cord-257558-dgnbfzli	10	14	on	on	IN
cord-257558-dgnbfzli	10	15	numerous	numerous	JJ
cord-257558-dgnbfzli	10	16	cell	cell	NN
cord-257558-dgnbfzli	10	17	types	type	NNS
cord-257558-dgnbfzli	10	18	(	(	-LRB-
cord-257558-dgnbfzli	10	19	Clarke	Clarke	NNP
cord-257558-dgnbfzli	10	20	et	et	NNP
cord-257558-dgnbfzli	10	21	al	al	NNP
cord-257558-dgnbfzli	10	22	.	.	NNP
cord-257558-dgnbfzli	10	23	,	,	,
cord-257558-dgnbfzli	10	24	2012	2012	CD
cord-257558-dgnbfzli	10	25	)	)	-RRB-
cord-257558-dgnbfzli	10	26	.	.	.
cord-257558-dgnbfzli	11	1	ACE2	ACE2	NNP
cord-257558-dgnbfzli	11	2	cleaves	cleave	VBZ
cord-257558-dgnbfzli	11	3	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	11	4	II	II	NNP
cord-257558-dgnbfzli	11	5	to	to	TO
cord-257558-dgnbfzli	11	6	produce	produce	VB
cord-257558-dgnbfzli	11	7	a	a	DT
cord-257558-dgnbfzli	11	8	small	small	JJ
cord-257558-dgnbfzli	11	9	peptide	peptide	NN
cord-257558-dgnbfzli	11	10	,	,	,
cord-257558-dgnbfzli	11	11	ang1	ang1	CD
cord-257558-dgnbfzli	11	12	-	-	SYM
cord-257558-dgnbfzli	11	13	7	7	CD
cord-257558-dgnbfzli	11	14	,	,	,
cord-257558-dgnbfzli	11	15	which	which	WDT
cord-257558-dgnbfzli	11	16	binds	bind	VBZ
cord-257558-dgnbfzli	11	17	to	to	IN
cord-257558-dgnbfzli	11	18	a	a	DT
cord-257558-dgnbfzli	11	19	G	g	NN
cord-257558-dgnbfzli	11	20	protein	protein	NN
cord-257558-dgnbfzli	11	21	-	-	HYPH
cord-257558-dgnbfzli	11	22	coupled	couple	VBN
cord-257558-dgnbfzli	11	23	receptor	receptor	NN
cord-257558-dgnbfzli	11	24	Mas	Mas	NNP
cord-257558-dgnbfzli	11	25	to	to	TO
cord-257558-dgnbfzli	11	26	induce	induce	VB
cord-257558-dgnbfzli	11	27	an	an	DT
cord-257558-dgnbfzli	11	28	anti	anti	JJ
cord-257558-dgnbfzli	11	29	-	-	JJ
cord-257558-dgnbfzli	11	30	inflammatory	inflammatory	JJ
cord-257558-dgnbfzli	11	31	and	and	CC
cord-257558-dgnbfzli	11	32	anti	anti	JJ
cord-257558-dgnbfzli	11	33	-	-	JJ
cord-257558-dgnbfzli	11	34	apoptotic	apoptotic	JJ
cord-257558-dgnbfzli	11	35	program	program	NN
cord-257558-dgnbfzli	11	36	and	and	CC
cord-257558-dgnbfzli	11	37	vasodilation	vasodilation	NN
cord-257558-dgnbfzli	12	1	(	(	-LRB-
cord-257558-dgnbfzli	12	2	Simões	Simões	NNP
cord-257558-dgnbfzli	12	3	e	e	NNP
cord-257558-dgnbfzli	12	4	Silva	Silva	NNP
cord-257558-dgnbfzli	12	5	et	et	NNP
cord-257558-dgnbfzli	12	6	al	al	NNP
cord-257558-dgnbfzli	12	7	.	.	NNP
cord-257558-dgnbfzli	12	8	,	,	,
cord-257558-dgnbfzli	12	9	2013	2013	CD
cord-257558-dgnbfzli	12	10	)	)	-RRB-
cord-257558-dgnbfzli	12	11	.	.	.
cord-257558-dgnbfzli	13	1	ACE2	ACE2	NNP
cord-257558-dgnbfzli	13	2	is	be	VBZ
cord-257558-dgnbfzli	13	3	the	the	DT
cord-257558-dgnbfzli	13	4	cellular	cellular	JJ
cord-257558-dgnbfzli	13	5	receptor	receptor	NN
cord-257558-dgnbfzli	13	6	for	for	IN
cord-257558-dgnbfzli	13	7	the	the	DT
cord-257558-dgnbfzli	13	8	SARS	SARS	NNP
cord-257558-dgnbfzli	13	9	-	-	HYPH
cord-257558-dgnbfzli	13	10	CoV-2	CoV-2	NNP
cord-257558-dgnbfzli	13	11	virus	virus	NN
cord-257558-dgnbfzli	14	1	(	(	-LRB-
cord-257558-dgnbfzli	14	2	Lan	Lan	NNP
cord-257558-dgnbfzli	14	3	et	et	FW
cord-257558-dgnbfzli	14	4	al	al	NNP
cord-257558-dgnbfzli	14	5	.	.	NNP
cord-257558-dgnbfzli	14	6	,	,	,
cord-257558-dgnbfzli	14	7	2020	2020	CD
cord-257558-dgnbfzli	14	8	)	)	-RRB-
cord-257558-dgnbfzli	14	9	,	,	,
cord-257558-dgnbfzli	14	10	the	the	DT
cord-257558-dgnbfzli	14	11	causative	causative	JJ
cord-257558-dgnbfzli	14	12	agent	agent	NN
cord-257558-dgnbfzli	14	13	for	for	IN
cord-257558-dgnbfzli	14	14	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	14	15	,	,	,
cord-257558-dgnbfzli	14	16	and	and	CC
cord-257558-dgnbfzli	14	17	permits	permit	VBZ
cord-257558-dgnbfzli	14	18	viral	viral	JJ
cord-257558-dgnbfzli	14	19	entry	entry	NN
cord-257558-dgnbfzli	14	20	into	into	IN
cord-257558-dgnbfzli	14	21	ACE2-expressing	ace2-expresse	VBG
cord-257558-dgnbfzli	14	22	cells	cell	NNS
cord-257558-dgnbfzli	14	23	.	.	.
cord-257558-dgnbfzli	15	1	When	when	WRB
cord-257558-dgnbfzli	15	2	the	the	DT
cord-257558-dgnbfzli	15	3	viral	viral	JJ
cord-257558-dgnbfzli	15	4	spike	spike	NN
cord-257558-dgnbfzli	15	5	protein	protein	NN
cord-257558-dgnbfzli	15	6	binds	bind	VBZ
cord-257558-dgnbfzli	15	7	ACE2	ACE2	NNP
cord-257558-dgnbfzli	15	8	,	,	,
cord-257558-dgnbfzli	15	9	however	however	RB
cord-257558-dgnbfzli	15	10	,	,	,
cord-257558-dgnbfzli	15	11	another	another	DT
cord-257558-dgnbfzli	15	12	protease	protease	NN
cord-257558-dgnbfzli	15	13	termed	term	VBN
cord-257558-dgnbfzli	15	14	TACE	TACE	NNP
cord-257558-dgnbfzli	15	15	,	,	,
cord-257558-dgnbfzli	15	16	or	or	CC
cord-257558-dgnbfzli	15	17	ADAM	ADAM	NNP
cord-257558-dgnbfzli	15	18	17	17	CD
cord-257558-dgnbfzli	15	19	,	,	,
cord-257558-dgnbfzli	15	20	is	be	VBZ
cord-257558-dgnbfzli	15	21	activated	activate	VBN
cord-257558-dgnbfzli	15	22	;	;	:
cord-257558-dgnbfzli	15	23	this	this	DT
cord-257558-dgnbfzli	15	24	causes	cause	VBZ
cord-257558-dgnbfzli	15	25	ACE2	ACE2	NNP
cord-257558-dgnbfzli	15	26	to	to	TO
cord-257558-dgnbfzli	15	27	be	be	VB
cord-257558-dgnbfzli	15	28	shed	shed	VBN
cord-257558-dgnbfzli	15	29	from	from	IN
cord-257558-dgnbfzli	15	30	the	the	DT
cord-257558-dgnbfzli	15	31	cell	cell	NN
cord-257558-dgnbfzli	15	32	membrane	membrane	NN
cord-257558-dgnbfzli	15	33	,	,	,
cord-257558-dgnbfzli	15	34	leading	lead	VBG
cord-257558-dgnbfzli	15	35	to	to	IN
cord-257558-dgnbfzli	15	36	decreased	decrease	VBN
cord-257558-dgnbfzli	15	37	degradation	degradation	NN
cord-257558-dgnbfzli	15	38	of	of	IN
cord-257558-dgnbfzli	15	39	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	15	40	II	II	NNP
cord-257558-dgnbfzli	15	41	and	and	CC
cord-257558-dgnbfzli	15	42	decreased	decrease	VBD
cord-257558-dgnbfzli	15	43	production	production	NN
cord-257558-dgnbfzli	15	44	of	of	IN
cord-257558-dgnbfzli	15	45	ang1	ang1	CD
cord-257558-dgnbfzli	15	46	-	-	SYM
cord-257558-dgnbfzli	15	47	7	7	CD
cord-257558-dgnbfzli	15	48	(	(	-LRB-
cord-257558-dgnbfzli	15	49	Shah	Shah	NNP
cord-257558-dgnbfzli	15	50	and	and	CC
cord-257558-dgnbfzli	15	51	Catt	Catt	NNP
cord-257558-dgnbfzli	15	52	,	,	,
cord-257558-dgnbfzli	15	53	2006	2006	CD
cord-257558-dgnbfzli	15	54	)	)	-RRB-
cord-257558-dgnbfzli	15	55	.	.	.
cord-257558-dgnbfzli	16	1	Interestingly	interestingly	RB
cord-257558-dgnbfzli	16	2	,	,	,
cord-257558-dgnbfzli	16	3	a	a	DT
cord-257558-dgnbfzli	16	4	high	high	JJ
cord-257558-dgnbfzli	16	5	concentration	concentration	NN
cord-257558-dgnbfzli	16	6	of	of	IN
cord-257558-dgnbfzli	16	7	aldosterone	aldosterone	NN
cord-257558-dgnbfzli	16	8	reduces	reduce	VBZ
cord-257558-dgnbfzli	16	9	Mas	Mas	NNP
cord-257558-dgnbfzli	16	10	expression	expression	NN
cord-257558-dgnbfzli	16	11	,	,	,
cord-257558-dgnbfzli	16	12	also	also	RB
cord-257558-dgnbfzli	16	13	impairing	impair	VBG
cord-257558-dgnbfzli	16	14	this	this	DT
cord-257558-dgnbfzli	16	15	arm	arm	NN
cord-257558-dgnbfzli	16	16	of	of	IN
cord-257558-dgnbfzli	16	17	the	the	DT
cord-257558-dgnbfzli	16	18	RAS	RAS	NNP
cord-257558-dgnbfzli	16	19	(	(	-LRB-
cord-257558-dgnbfzli	16	20	Stoll	Stoll	NNP
cord-257558-dgnbfzli	16	21	et	et	NNP
cord-257558-dgnbfzli	16	22	al	al	NNP
cord-257558-dgnbfzli	16	23	.	.	NNP
cord-257558-dgnbfzli	16	24	,	,	,
cord-257558-dgnbfzli	16	25	2019	2019	CD
cord-257558-dgnbfzli	16	26	)	)	-RRB-
cord-257558-dgnbfzli	16	27	.	.	.
cord-257558-dgnbfzli	17	1	So	so	RB
cord-257558-dgnbfzli	17	2	how	how	WRB
cord-257558-dgnbfzli	17	3	does	do	VBZ
cord-257558-dgnbfzli	17	4	this	this	DT
cord-257558-dgnbfzli	17	5	relate	relate	VB
cord-257558-dgnbfzli	17	6	to	to	TO
cord-257558-dgnbfzli	17	7	COVID-19	covid-19	VB
cord-257558-dgnbfzli	17	8	?	?	.
cord-257558-dgnbfzli	18	1	SARS	SARS	NNP
cord-257558-dgnbfzli	18	2	-	-	HYPH
cord-257558-dgnbfzli	18	3	CoV-2	CoV-2	NNP
cord-257558-dgnbfzli	18	4	infection	infection	NN
cord-257558-dgnbfzli	18	5	can	can	MD
cord-257558-dgnbfzli	18	6	cause	cause	VB
cord-257558-dgnbfzli	18	7	a	a	DT
cord-257558-dgnbfzli	18	8	particularly	particularly	RB
cord-257558-dgnbfzli	18	9	severe	severe	JJ
cord-257558-dgnbfzli	18	10	disease	disease	NN
cord-257558-dgnbfzli	18	11	in	in	IN
cord-257558-dgnbfzli	18	12	hypertensive	hypertensive	JJ
cord-257558-dgnbfzli	18	13	and	and	CC
cord-257558-dgnbfzli	18	14	obese	obese	JJ
cord-257558-dgnbfzli	18	15	individuals	individual	NNS
cord-257558-dgnbfzli	18	16	(	(	-LRB-
cord-257558-dgnbfzli	18	17	Kenyon	Kenyon	NNP
cord-257558-dgnbfzli	18	18	,	,	,
cord-257558-dgnbfzli	18	19	2020	2020	CD
cord-257558-dgnbfzli	18	20	;	;	:
cord-257558-dgnbfzli	18	21	Richardson	Richardson	NNP
cord-257558-dgnbfzli	18	22	et	et	NNP
cord-257558-dgnbfzli	18	23	al	al	NNP
cord-257558-dgnbfzli	18	24	.	.	NNP
cord-257558-dgnbfzli	18	25	,	,	,
cord-257558-dgnbfzli	18	26	2020	2020	CD
cord-257558-dgnbfzli	18	27	)	)	-RRB-
cord-257558-dgnbfzli	18	28	.	.	.
cord-257558-dgnbfzli	19	1	Hypertensive	hypertensive	JJ
cord-257558-dgnbfzli	19	2	individuals	individual	NNS
cord-257558-dgnbfzli	19	3	generally	generally	RB
cord-257558-dgnbfzli	19	4	have	have	VBP
cord-257558-dgnbfzli	19	5	high	high	JJ
cord-257558-dgnbfzli	19	6	levels	level	NNS
cord-257558-dgnbfzli	19	7	of	of	IN
cord-257558-dgnbfzli	19	8	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	19	9	and	and	CC
cord-257558-dgnbfzli	19	10	high	high	JJ
cord-257558-dgnbfzli	19	11	levels	level	NNS
cord-257558-dgnbfzli	19	12	of	of	IN
cord-257558-dgnbfzli	19	13	TF	TF	NNP
cord-257558-dgnbfzli	19	14	,	,	,
cord-257558-dgnbfzli	19	15	leading	lead	VBG
cord-257558-dgnbfzli	19	16	to	to	IN
cord-257558-dgnbfzli	19	17	the	the	DT
cord-257558-dgnbfzli	19	18	hypercoagulable	hypercoagulable	JJ
cord-257558-dgnbfzli	19	19	state	state	NN
cord-257558-dgnbfzli	19	20	that	that	WDT
cord-257558-dgnbfzli	19	21	is	be	VBZ
cord-257558-dgnbfzli	19	22	seen	see	VBN
cord-257558-dgnbfzli	19	23	in	in	IN
cord-257558-dgnbfzli	19	24	hypertension	hypertension	NN
cord-257558-dgnbfzli	19	25	(	(	-LRB-
cord-257558-dgnbfzli	19	26	Dielis	Dielis	NNP
cord-257558-dgnbfzli	19	27	et	et	FW
cord-257558-dgnbfzli	19	28	al	al	NNP
cord-257558-dgnbfzli	19	29	.	.	NNP
cord-257558-dgnbfzli	19	30	,	,	,
cord-257558-dgnbfzli	19	31	2005	2005	CD
cord-257558-dgnbfzli	19	32	)	)	-RRB-
cord-257558-dgnbfzli	19	33	.	.	.
cord-257558-dgnbfzli	20	1	It	-PRON-	PRP
cord-257558-dgnbfzli	20	2	is	be	VBZ
cord-257558-dgnbfzli	20	3	important	important	JJ
cord-257558-dgnbfzli	20	4	to	to	TO
cord-257558-dgnbfzli	20	5	note	note	VB
cord-257558-dgnbfzli	20	6	that	that	IN
cord-257558-dgnbfzli	20	7	renin	renin	NN
cord-257558-dgnbfzli	20	8	levels	level	NNS
cord-257558-dgnbfzli	20	9	are	be	VBP
cord-257558-dgnbfzli	20	10	often	often	RB
cord-257558-dgnbfzli	20	11	low	low	JJ
cord-257558-dgnbfzli	20	12	in	in	IN
cord-257558-dgnbfzli	20	13	African	african	JJ
cord-257558-dgnbfzli	20	14	Americans	Americans	NNPS
cord-257558-dgnbfzli	20	15	,	,	,
cord-257558-dgnbfzli	20	16	but	but	CC
cord-257558-dgnbfzli	20	17	there	there	EX
cord-257558-dgnbfzli	20	18	is	be	VBZ
cord-257558-dgnbfzli	20	19	evidence	evidence	NN
cord-257558-dgnbfzli	20	20	in	in	IN
cord-257558-dgnbfzli	20	21	rodent	rodent	NN
cord-257558-dgnbfzli	20	22	models	model	NNS
cord-257558-dgnbfzli	20	23	that	that	IN
cord-257558-dgnbfzli	20	24	tissue	tissue	NN
cord-257558-dgnbfzli	20	25	levels	level	NNS
cord-257558-dgnbfzli	20	26	of	of	IN
cord-257558-dgnbfzli	20	27	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	20	28	may	may	MD
cord-257558-dgnbfzli	20	29	be	be	VB
cord-257558-dgnbfzli	20	30	high	high	JJ
cord-257558-dgnbfzli	20	31	even	even	RB
cord-257558-dgnbfzli	20	32	in	in	IN
cord-257558-dgnbfzli	20	33	the	the	DT
cord-257558-dgnbfzli	20	34	face	face	NN
cord-257558-dgnbfzli	20	35	of	of	IN
cord-257558-dgnbfzli	20	36	low	low	JJ
cord-257558-dgnbfzli	20	37	renin	renin	NN
cord-257558-dgnbfzli	20	38	(	(	-LRB-
cord-257558-dgnbfzli	20	39	Williams	Williams	NNP
cord-257558-dgnbfzli	20	40	et	et	NNP
cord-257558-dgnbfzli	20	41	al	al	NNP
cord-257558-dgnbfzli	20	42	.	.	NNP
cord-257558-dgnbfzli	20	43	,	,	,
cord-257558-dgnbfzli	20	44	2014	2014	CD
cord-257558-dgnbfzli	20	45	)	)	-RRB-
cord-257558-dgnbfzli	20	46	.	.	.
cord-257558-dgnbfzli	21	1	Obesity	obesity	NN
cord-257558-dgnbfzli	21	2	is	be	VBZ
cord-257558-dgnbfzli	21	3	associated	associate	VBN
cord-257558-dgnbfzli	21	4	with	with	IN
cord-257558-dgnbfzli	21	5	high	high	JJ
cord-257558-dgnbfzli	21	6	levels	level	NNS
cord-257558-dgnbfzli	21	7	of	of	IN
cord-257558-dgnbfzli	21	8	ACE	ace	NN
cord-257558-dgnbfzli	21	9	and	and	CC
cord-257558-dgnbfzli	21	10	AT1	AT1	NNP
cord-257558-dgnbfzli	21	11	(	(	-LRB-
cord-257558-dgnbfzli	21	12	Barton	Barton	NNP
cord-257558-dgnbfzli	21	13	et	et	NNP
cord-257558-dgnbfzli	21	14	al	al	NNP
cord-257558-dgnbfzli	21	15	.	.	NNP
cord-257558-dgnbfzli	21	16	,	,	,
cord-257558-dgnbfzli	21	17	2000	2000	CD
cord-257558-dgnbfzli	21	18	)	)	-RRB-
cord-257558-dgnbfzli	21	19	.	.	.
cord-257558-dgnbfzli	22	1	Both	both	DT
cord-257558-dgnbfzli	22	2	of	of	IN
cord-257558-dgnbfzli	22	3	these	these	DT
cord-257558-dgnbfzli	22	4	comorbidities	comorbiditie	NNS
cord-257558-dgnbfzli	22	5	will	will	MD
cord-257558-dgnbfzli	22	6	,	,	,
cord-257558-dgnbfzli	22	7	therefore	therefore	RB
cord-257558-dgnbfzli	22	8	,	,	,
cord-257558-dgnbfzli	22	9	enhance	enhance	VB
cord-257558-dgnbfzli	22	10	the	the	DT
cord-257558-dgnbfzli	22	11	pro	pro	JJ
cord-257558-dgnbfzli	22	12	-	-	JJ
cord-257558-dgnbfzli	22	13	inflammatory	inflammatory	JJ
cord-257558-dgnbfzli	22	14	,	,	,
cord-257558-dgnbfzli	22	15	pro	pro	JJ
cord-257558-dgnbfzli	22	16	-	-	JJ
cord-257558-dgnbfzli	22	17	apoptotic	apoptotic	JJ
cord-257558-dgnbfzli	22	18	,	,	,
cord-257558-dgnbfzli	22	19	procoagulant	procoagulant	JJ
cord-257558-dgnbfzli	22	20	arms	arm	NNS
cord-257558-dgnbfzli	22	21	of	of	IN
cord-257558-dgnbfzli	22	22	the	the	DT
cord-257558-dgnbfzli	22	23	RAS	RAS	NNP
cord-257558-dgnbfzli	22	24	.	.	.
cord-257558-dgnbfzli	23	1	A	a	DT
cord-257558-dgnbfzli	23	2	model	model	NN
cord-257558-dgnbfzli	23	3	of	of	IN
cord-257558-dgnbfzli	23	4	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	23	5	might	may	MD
cord-257558-dgnbfzli	23	6	be	be	VB
cord-257558-dgnbfzli	23	7	that	that	IN
cord-257558-dgnbfzli	23	8	SARS	SARS	NNP
cord-257558-dgnbfzli	23	9	-	-	HYPH
cord-257558-dgnbfzli	23	10	CoV-2	CoV-2	NNP
cord-257558-dgnbfzli	23	11	infects	infect	VBZ
cord-257558-dgnbfzli	23	12	lung	lung	NN
cord-257558-dgnbfzli	23	13	alveolar	alveolar	NN
cord-257558-dgnbfzli	23	14	epithelial	epithelial	JJ
cord-257558-dgnbfzli	23	15	cells	cell	NNS
cord-257558-dgnbfzli	23	16	,	,	,
cord-257558-dgnbfzli	23	17	the	the	DT
cord-257558-dgnbfzli	23	18	source	source	NN
cord-257558-dgnbfzli	23	19	of	of	IN
cord-257558-dgnbfzli	23	20	surfactant	surfactant	NN
cord-257558-dgnbfzli	23	21	,	,	,
cord-257558-dgnbfzli	23	22	causing	cause	VBG
cord-257558-dgnbfzli	23	23	a	a	DT
cord-257558-dgnbfzli	23	24	cytopathic	cytopathic	JJ
cord-257558-dgnbfzli	23	25	effect	effect	NN
cord-257558-dgnbfzli	23	26	.	.	.
cord-257558-dgnbfzli	24	1	In	in	IN
cord-257558-dgnbfzli	24	2	addition	addition	NN
cord-257558-dgnbfzli	24	3	,	,	,
cord-257558-dgnbfzli	24	4	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	24	5	II	II	NNP
cord-257558-dgnbfzli	24	6	binding	bind	VBG
cord-257558-dgnbfzli	24	7	to	to	IN
cord-257558-dgnbfzli	24	8	alveolar	alveolar	JJ
cord-257558-dgnbfzli	24	9	epithelial	epithelial	JJ
cord-257558-dgnbfzli	24	10	cells	cell	NNS
cord-257558-dgnbfzli	24	11	induces	induce	VBZ
cord-257558-dgnbfzli	24	12	their	-PRON-	PRP$
cord-257558-dgnbfzli	24	13	death	death	NN
cord-257558-dgnbfzli	24	14	through	through	IN
cord-257558-dgnbfzli	24	15	apoptosis	apoptosis	NN
cord-257558-dgnbfzli	24	16	.	.	.
cord-257558-dgnbfzli	25	1	Because	because	IN
cord-257558-dgnbfzli	25	2	ACE2	ACE2	NNP
cord-257558-dgnbfzli	25	3	is	be	VBZ
cord-257558-dgnbfzli	25	4	shed	shed	VBN
cord-257558-dgnbfzli	25	5	when	when	WRB
cord-257558-dgnbfzli	25	6	bound	bind	VBN
cord-257558-dgnbfzli	25	7	by	by	IN
cord-257558-dgnbfzli	25	8	spike	spike	NN
cord-257558-dgnbfzli	25	9	protein	protein	NN
cord-257558-dgnbfzli	25	10	,	,	,
cord-257558-dgnbfzli	25	11	we	-PRON-	PRP
cord-257558-dgnbfzli	25	12	speculate	speculate	VBP
cord-257558-dgnbfzli	25	13	that	that	IN
cord-257558-dgnbfzli	25	14	ang1	ang1	CD
cord-257558-dgnbfzli	25	15	-	-	SYM
cord-257558-dgnbfzli	25	16	7	7	CD
cord-257558-dgnbfzli	25	17	is	be	VBZ
cord-257558-dgnbfzli	25	18	not	not	RB
cord-257558-dgnbfzli	25	19	generated	generate	VBN
cord-257558-dgnbfzli	25	20	.	.	.
cord-257558-dgnbfzli	26	1	With	with	IN
cord-257558-dgnbfzli	26	2	diminished	diminish	VBN
cord-257558-dgnbfzli	26	3	ang1	ang1	NNP
cord-257558-dgnbfzli	26	4	-	-	SYM
cord-257558-dgnbfzli	26	5	7	7	CD
cord-257558-dgnbfzli	26	6	to	to	TO
cord-257558-dgnbfzli	26	7	bind	bind	VB
cord-257558-dgnbfzli	26	8	Mas	Mas	NNP
cord-257558-dgnbfzli	26	9	,	,	,
cord-257558-dgnbfzli	26	10	there	there	EX
cord-257558-dgnbfzli	26	11	may	may	MD
cord-257558-dgnbfzli	26	12	be	be	VB
cord-257558-dgnbfzli	26	13	no	no	DT
cord-257558-dgnbfzli	26	14	activation	activation	NN
cord-257558-dgnbfzli	26	15	of	of	IN
cord-257558-dgnbfzli	26	16	the	the	DT
cord-257558-dgnbfzli	26	17	arm	arm	NN
cord-257558-dgnbfzli	26	18	of	of	IN
cord-257558-dgnbfzli	26	19	the	the	DT
cord-257558-dgnbfzli	26	20	RAS	RAS	NNP
cord-257558-dgnbfzli	26	21	pathway	pathway	NN
cord-257558-dgnbfzli	26	22	that	that	WDT
cord-257558-dgnbfzli	26	23	protects	protect	VBZ
cord-257558-dgnbfzli	26	24	against	against	IN
cord-257558-dgnbfzli	26	25	apoptosis	apoptosis	NN
cord-257558-dgnbfzli	26	26	.	.	.
cord-257558-dgnbfzli	27	1	First	first	RB
cord-257558-dgnbfzli	27	2	,	,	,
cord-257558-dgnbfzli	27	3	therefore	therefore	RB
cord-257558-dgnbfzli	27	4	,	,	,
cord-257558-dgnbfzli	27	5	we	-PRON-	PRP
cord-257558-dgnbfzli	27	6	suggest	suggest	VBP
cord-257558-dgnbfzli	27	7	there	there	EX
cord-257558-dgnbfzli	27	8	is	be	VBZ
cord-257558-dgnbfzli	27	9	a	a	DT
cord-257558-dgnbfzli	27	10	collapse	collapse	NN
cord-257558-dgnbfzli	27	11	of	of	IN
cord-257558-dgnbfzli	27	12	alveolae	alveolae	NNS
cord-257558-dgnbfzli	27	13	with	with	IN
cord-257558-dgnbfzli	27	14	ensuing	ensue	VBG
cord-257558-dgnbfzli	27	15	hypoxia	hypoxia	NN
cord-257558-dgnbfzli	27	16	.	.	.
cord-257558-dgnbfzli	28	1	Because	because	IN
cord-257558-dgnbfzli	28	2	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	28	3	II	II	NNP
cord-257558-dgnbfzli	28	4	increases	increase	VBZ
cord-257558-dgnbfzli	28	5	vascular	vascular	JJ
cord-257558-dgnbfzli	28	6	permeability	permeability	NN
cord-257558-dgnbfzli	28	7	,	,	,
cord-257558-dgnbfzli	28	8	there	there	EX
cord-257558-dgnbfzli	28	9	may	may	MD
cord-257558-dgnbfzli	28	10	be	be	VB
cord-257558-dgnbfzli	28	11	extravasation	extravasation	NN
cord-257558-dgnbfzli	28	12	of	of	IN
cord-257558-dgnbfzli	28	13	neutrophils	neutrophil	NNS
cord-257558-dgnbfzli	28	14	into	into	IN
cord-257558-dgnbfzli	28	15	alveolae	alveolae	NNS
cord-257558-dgnbfzli	28	16	.	.	.
cord-257558-dgnbfzli	29	1	Moreover	moreover	RB
cord-257558-dgnbfzli	29	2	,	,	,
cord-257558-dgnbfzli	29	3	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	29	4	II	ii	CD
cord-257558-dgnbfzli	29	5	acting	act	VBG
cord-257558-dgnbfzli	29	6	on	on	IN
cord-257558-dgnbfzli	29	7	endothelial	endothelial	JJ
cord-257558-dgnbfzli	29	8	cells	cell	NNS
cord-257558-dgnbfzli	29	9	induces	induce	VBZ
cord-257558-dgnbfzli	29	10	IL-8	IL-8	NNP
cord-257558-dgnbfzli	29	11	leading	lead	VBG
cord-257558-dgnbfzli	29	12	to	to	IN
cord-257558-dgnbfzli	29	13	neutrophil	neutrophil	NN
cord-257558-dgnbfzli	29	14	recruitment	recruitment	NN
cord-257558-dgnbfzli	29	15	(	(	-LRB-
cord-257558-dgnbfzli	29	16	Nabah	Nabah	NNP
cord-257558-dgnbfzli	29	17	et	et	NNP
cord-257558-dgnbfzli	29	18	al	al	NNP
cord-257558-dgnbfzli	29	19	.	.	NNP
cord-257558-dgnbfzli	29	20	,	,	,
cord-257558-dgnbfzli	29	21	2004	2004	CD
cord-257558-dgnbfzli	29	22	)	)	-RRB-
cord-257558-dgnbfzli	29	23	.	.	.
cord-257558-dgnbfzli	30	1	These	these	DT
cord-257558-dgnbfzli	30	2	neutrophils	neutrophil	NNS
cord-257558-dgnbfzli	30	3	can	can	MD
cord-257558-dgnbfzli	30	4	release	release	VB
cord-257558-dgnbfzli	30	5	ROS	ROS	NNP
cord-257558-dgnbfzli	30	6	and	and	CC
cord-257558-dgnbfzli	30	7	form	form	NN
cord-257558-dgnbfzli	30	8	neutrophil	neutrophil	NN
cord-257558-dgnbfzli	30	9	extracellular	extracellular	JJ
cord-257558-dgnbfzli	30	10	traps	trap	NNS
cord-257558-dgnbfzli	30	11	(	(	-LRB-
cord-257558-dgnbfzli	30	12	Khan	Khan	NNP
cord-257558-dgnbfzli	30	13	et	et	NNP
cord-257558-dgnbfzli	30	14	al	al	NNP
cord-257558-dgnbfzli	30	15	.	.	NNP
cord-257558-dgnbfzli	30	16	,	,	,
cord-257558-dgnbfzli	30	17	2017	2017	CD
cord-257558-dgnbfzli	30	18	)	)	-RRB-
cord-257558-dgnbfzli	30	19	.	.	.
cord-257558-dgnbfzli	31	1	Indeed	indeed	RB
cord-257558-dgnbfzli	31	2	,	,	,
cord-257558-dgnbfzli	31	3	neutrophils	neutrophil	NNS
cord-257558-dgnbfzli	31	4	in	in	IN
cord-257558-dgnbfzli	31	5	the	the	DT
cord-257558-dgnbfzli	31	6	alveolae	alveolae	NNS
cord-257558-dgnbfzli	31	7	have	have	VBP
cord-257558-dgnbfzli	31	8	been	be	VBN
cord-257558-dgnbfzli	31	9	seen	see	VBN
cord-257558-dgnbfzli	31	10	in	in	IN
cord-257558-dgnbfzli	31	11	lung	lung	NN
cord-257558-dgnbfzli	31	12	pathology	pathology	NN
cord-257558-dgnbfzli	31	13	of	of	IN
cord-257558-dgnbfzli	31	14	infected	infected	JJ
cord-257558-dgnbfzli	31	15	patients	patient	NNS
cord-257558-dgnbfzli	31	16	(	(	-LRB-
cord-257558-dgnbfzli	31	17	Barnes	Barnes	NNP
cord-257558-dgnbfzli	31	18	et	et	NNP
cord-257558-dgnbfzli	31	19	al	al	NNP
cord-257558-dgnbfzli	31	20	.	.	NNP
cord-257558-dgnbfzli	31	21	,	,	,
cord-257558-dgnbfzli	31	22	2020	2020	CD
cord-257558-dgnbfzli	31	23	)	)	-RRB-
cord-257558-dgnbfzli	31	24	.	.	.
cord-257558-dgnbfzli	32	1	This	this	DT
cord-257558-dgnbfzli	32	2	accumulation	accumulation	NN
cord-257558-dgnbfzli	32	3	of	of	IN
cord-257558-dgnbfzli	32	4	neutrophils	neutrophil	NNS
cord-257558-dgnbfzli	32	5	,	,	,
cord-257558-dgnbfzli	32	6	we	-PRON-	PRP
cord-257558-dgnbfzli	32	7	propose	propose	VBP
cord-257558-dgnbfzli	32	8	,	,	,
cord-257558-dgnbfzli	32	9	will	will	MD
cord-257558-dgnbfzli	32	10	lead	lead	VB
cord-257558-dgnbfzli	32	11	to	to	IN
cord-257558-dgnbfzli	32	12	netosis	netosis	NNP
cord-257558-dgnbfzli	32	13	and	and	CC
cord-257558-dgnbfzli	32	14	hypercapnia	hypercapnia	NN
cord-257558-dgnbfzli	32	15	with	with	IN
cord-257558-dgnbfzli	32	16	inadequate	inadequate	JJ
cord-257558-dgnbfzli	32	17	diffusion	diffusion	NN
cord-257558-dgnbfzli	32	18	of	of	IN
cord-257558-dgnbfzli	32	19	CO	CO	NNP
cord-257558-dgnbfzli	32	20	2	2	CD
cord-257558-dgnbfzli	32	21	through	through	IN
cord-257558-dgnbfzli	32	22	the	the	DT
cord-257558-dgnbfzli	32	23	alveolae	alveolae	NNS
cord-257558-dgnbfzli	32	24	if	if	IN
cord-257558-dgnbfzli	32	25	our	-PRON-	PRP$
cord-257558-dgnbfzli	32	26	model	model	NN
cord-257558-dgnbfzli	32	27	is	be	VBZ
cord-257558-dgnbfzli	32	28	correct	correct	JJ
cord-257558-dgnbfzli	32	29	.	.	.
cord-257558-dgnbfzli	33	1	Surfactant	surfactant	NN
cord-257558-dgnbfzli	33	2	,	,	,
cord-257558-dgnbfzli	33	3	which	which	WDT
cord-257558-dgnbfzli	33	4	usually	usually	RB
cord-257558-dgnbfzli	33	5	protects	protect	VBZ
cord-257558-dgnbfzli	33	6	against	against	IN
cord-257558-dgnbfzli	33	7	netosis	netosis	NNP
cord-257558-dgnbfzli	33	8	(	(	-LRB-
cord-257558-dgnbfzli	33	9	Rodriguez	Rodriguez	NNP
cord-257558-dgnbfzli	33	10	et	et	NNP
cord-257558-dgnbfzli	33	11	al	al	NNP
cord-257558-dgnbfzli	33	12	.	.	NNP
cord-257558-dgnbfzli	33	13	,	,	,
cord-257558-dgnbfzli	33	14	2019	2019	CD
cord-257558-dgnbfzli	33	15	)	)	-RRB-
cord-257558-dgnbfzli	33	16	,	,	,
cord-257558-dgnbfzli	33	17	will	will	MD
cord-257558-dgnbfzli	33	18	be	be	VB
cord-257558-dgnbfzli	33	19	sparse	sparse	JJ
cord-257558-dgnbfzli	33	20	due	due	IN
cord-257558-dgnbfzli	33	21	to	to	IN
cord-257558-dgnbfzli	33	22	the	the	DT
cord-257558-dgnbfzli	33	23	loss	loss	NN
cord-257558-dgnbfzli	33	24	of	of	IN
cord-257558-dgnbfzli	33	25	alveolar	alveolar	JJ
cord-257558-dgnbfzli	33	26	epithelial	epithelial	JJ
cord-257558-dgnbfzli	33	27	cells	cell	NNS
cord-257558-dgnbfzli	33	28	.	.	.
cord-257558-dgnbfzli	34	1	This	this	DT
cord-257558-dgnbfzli	34	2	may	may	MD
cord-257558-dgnbfzli	34	3	lead	lead	VB
cord-257558-dgnbfzli	34	4	to	to	IN
cord-257558-dgnbfzli	34	5	an	an	DT
cord-257558-dgnbfzli	34	6	impairment	impairment	NN
cord-257558-dgnbfzli	34	7	in	in	IN
cord-257558-dgnbfzli	34	8	lung	lung	NN
cord-257558-dgnbfzli	34	9	function	function	NN
cord-257558-dgnbfzli	34	10	that	that	WDT
cord-257558-dgnbfzli	34	11	appears	appear	VBZ
cord-257558-dgnbfzli	34	12	to	to	TO
cord-257558-dgnbfzli	34	13	be	be	VB
cord-257558-dgnbfzli	34	14	like	like	IN
cord-257558-dgnbfzli	34	15	what	what	WP
cord-257558-dgnbfzli	34	16	is	be	VBZ
cord-257558-dgnbfzli	34	17	seen	see	VBN
cord-257558-dgnbfzli	34	18	in	in	IN
cord-257558-dgnbfzli	34	19	acute	acute	JJ
cord-257558-dgnbfzli	34	20	respiratory	respiratory	JJ
cord-257558-dgnbfzli	34	21	distress	distress	NN
cord-257558-dgnbfzli	34	22	syndrome	syndrome	NN
cord-257558-dgnbfzli	34	23	,	,	,
cord-257558-dgnbfzli	34	24	but	but	CC
cord-257558-dgnbfzli	34	25	in	in	IN
cord-257558-dgnbfzli	34	26	SARS	SARS	NNP
cord-257558-dgnbfzli	34	27	-	-	HYPH
cord-257558-dgnbfzli	34	28	CoV-2	CoV-2	NNP
cord-257558-dgnbfzli	34	29	infection	infection	NN
cord-257558-dgnbfzli	34	30	,	,	,
cord-257558-dgnbfzli	34	31	the	the	DT
cord-257558-dgnbfzli	34	32	destruction	destruction	NN
cord-257558-dgnbfzli	34	33	of	of	IN
cord-257558-dgnbfzli	34	34	lung	lung	NN
cord-257558-dgnbfzli	34	35	function	function	NN
cord-257558-dgnbfzli	34	36	may	may	MD
cord-257558-dgnbfzli	34	37	progress	progress	VB
cord-257558-dgnbfzli	34	38	through	through	IN
cord-257558-dgnbfzli	34	39	a	a	DT
cord-257558-dgnbfzli	34	40	different	different	JJ
cord-257558-dgnbfzli	34	41	pathway	pathway	NN
cord-257558-dgnbfzli	34	42	.	.	.
cord-257558-dgnbfzli	35	1	In	in	IN
cord-257558-dgnbfzli	35	2	acute	acute	JJ
cord-257558-dgnbfzli	35	3	respiratory	respiratory	JJ
cord-257558-dgnbfzli	35	4	distress	distress	NN
cord-257558-dgnbfzli	35	5	syndrome	syndrome	NN
cord-257558-dgnbfzli	35	6	,	,	,
cord-257558-dgnbfzli	35	7	the	the	DT
cord-257558-dgnbfzli	35	8	loss	loss	NN
cord-257558-dgnbfzli	35	9	of	of	IN
cord-257558-dgnbfzli	35	10	lung	lung	NN
cord-257558-dgnbfzli	35	11	function	function	NN
cord-257558-dgnbfzli	35	12	is	be	VBZ
cord-257558-dgnbfzli	35	13	a	a	DT
cord-257558-dgnbfzli	35	14	consequence	consequence	NN
cord-257558-dgnbfzli	35	15	of	of	IN
cord-257558-dgnbfzli	35	16	cytokine	cytokine	NN
cord-257558-dgnbfzli	35	17	storm	storm	NN
cord-257558-dgnbfzli	35	18	due	due	IN
cord-257558-dgnbfzli	35	19	to	to	IN
cord-257558-dgnbfzli	35	20	the	the	DT
cord-257558-dgnbfzli	35	21	activation	activation	NN
cord-257558-dgnbfzli	35	22	of	of	IN
cord-257558-dgnbfzli	35	23	the	the	DT
cord-257558-dgnbfzli	35	24	innate	innate	JJ
cord-257558-dgnbfzli	35	25	and	and	CC
cord-257558-dgnbfzli	35	26	adaptive	adaptive	JJ
cord-257558-dgnbfzli	35	27	immune	immune	JJ
cord-257558-dgnbfzli	35	28	systems	system	NNS
cord-257558-dgnbfzli	35	29	.	.	.
cord-257558-dgnbfzli	36	1	We	-PRON-	PRP
cord-257558-dgnbfzli	36	2	propose	propose	VBP
cord-257558-dgnbfzli	36	3	that	that	IN
cord-257558-dgnbfzli	36	4	,	,	,
cord-257558-dgnbfzli	36	5	in	in	IN
cord-257558-dgnbfzli	36	6	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	36	7	,	,	,
cord-257558-dgnbfzli	36	8	the	the	DT
cord-257558-dgnbfzli	36	9	lung	lung	NN
cord-257558-dgnbfzli	36	10	is	be	VBZ
cord-257558-dgnbfzli	36	11	destroyed	destroy	VBN
cord-257558-dgnbfzli	36	12	by	by	IN
cord-257558-dgnbfzli	36	13	a	a	DT
cord-257558-dgnbfzli	36	14	combination	combination	NN
cord-257558-dgnbfzli	36	15	of	of	IN
cord-257558-dgnbfzli	36	16	the	the	DT
cord-257558-dgnbfzli	36	17	cytopathic	cytopathic	JJ
cord-257558-dgnbfzli	36	18	effect	effect	NN
cord-257558-dgnbfzli	36	19	of	of	IN
cord-257558-dgnbfzli	36	20	the	the	DT
cord-257558-dgnbfzli	36	21	virus	virus	NN
cord-257558-dgnbfzli	36	22	and	and	CC
cord-257558-dgnbfzli	36	23	an	an	DT
cord-257558-dgnbfzli	36	24	imbalanced	imbalanced	JJ
cord-257558-dgnbfzli	36	25	RAS	RAS	NNP
cord-257558-dgnbfzli	36	26	with	with	IN
cord-257558-dgnbfzli	36	27	too	too	RB
cord-257558-dgnbfzli	36	28	much	much	JJ
cord-257558-dgnbfzli	36	29	AT1	at1	NN
cord-257558-dgnbfzli	36	30	and	and	CC
cord-257558-dgnbfzli	36	31	insufficient	insufficient	JJ
cord-257558-dgnbfzli	36	32	ACE2	ACE2	NNP
cord-257558-dgnbfzli	37	1	(	(	-LRB-
cord-257558-dgnbfzli	37	2	Fig	Fig	NNP
cord-257558-dgnbfzli	37	3	.	.	NNP
cord-257558-dgnbfzli	37	4	1	1	CD
cord-257558-dgnbfzli	37	5	)	)	-RRB-
cord-257558-dgnbfzli	37	6	.	.	.
cord-257558-dgnbfzli	38	1	This	this	DT
cord-257558-dgnbfzli	38	2	is	be	VBZ
cord-257558-dgnbfzli	38	3	the	the	DT
cord-257558-dgnbfzli	38	4	crux	crux	NN
cord-257558-dgnbfzli	38	5	of	of	IN
cord-257558-dgnbfzli	38	6	the	the	DT
cord-257558-dgnbfzli	38	7	issue	issue	NN
cord-257558-dgnbfzli	38	8	and	and	CC
cord-257558-dgnbfzli	38	9	would	would	MD
cord-257558-dgnbfzli	38	10	explain	explain	VB
cord-257558-dgnbfzli	38	11	the	the	DT
cord-257558-dgnbfzli	38	12	greater	great	JJR
cord-257558-dgnbfzli	38	13	disease	disease	NN
cord-257558-dgnbfzli	38	14	severity	severity	NN
cord-257558-dgnbfzli	38	15	in	in	IN
cord-257558-dgnbfzli	38	16	the	the	DT
cord-257558-dgnbfzli	38	17	elderly	elderly	JJ
cord-257558-dgnbfzli	38	18	as	as	RB
cord-257558-dgnbfzli	38	19	well	well	RB
cord-257558-dgnbfzli	38	20	as	as	IN
cord-257558-dgnbfzli	38	21	in	in	IN
cord-257558-dgnbfzli	38	22	hypertensive	hypertensive	JJ
cord-257558-dgnbfzli	38	23	and	and	CC
cord-257558-dgnbfzli	38	24	obese	obese	JJ
cord-257558-dgnbfzli	38	25	individuals	individual	NNS
cord-257558-dgnbfzli	38	26	,	,	,
cord-257558-dgnbfzli	38	27	rather	rather	RB
cord-257558-dgnbfzli	38	28	than	than	IN
cord-257558-dgnbfzli	38	29	in	in	IN
cord-257558-dgnbfzli	38	30	young	young	JJ
cord-257558-dgnbfzli	38	31	and	and	CC
cord-257558-dgnbfzli	38	32	healthy	healthy	JJ
cord-257558-dgnbfzli	38	33	individuals	individual	NNS
cord-257558-dgnbfzli	38	34	.	.	.
cord-257558-dgnbfzli	39	1	In	in	IN
cord-257558-dgnbfzli	39	2	this	this	DT
cord-257558-dgnbfzli	39	3	model	model	NN
cord-257558-dgnbfzli	39	4	,	,	,
cord-257558-dgnbfzli	39	5	the	the	DT
cord-257558-dgnbfzli	39	6	key	key	JJ
cord-257558-dgnbfzli	39	7	issue	issue	NN
cord-257558-dgnbfzli	39	8	is	be	VBZ
cord-257558-dgnbfzli	39	9	the	the	DT
cord-257558-dgnbfzli	39	10	loss	loss	NN
cord-257558-dgnbfzli	39	11	of	of	IN
cord-257558-dgnbfzli	39	12	ACE2	ACE2	NNP
cord-257558-dgnbfzli	39	13	due	due	IN
cord-257558-dgnbfzli	39	14	to	to	IN
cord-257558-dgnbfzli	39	15	ACE2	ACE2	NNP
cord-257558-dgnbfzli	39	16	engagement	engagement	NN
cord-257558-dgnbfzli	39	17	of	of	IN
cord-257558-dgnbfzli	39	18	the	the	DT
cord-257558-dgnbfzli	39	19	spike	spike	NN
cord-257558-dgnbfzli	39	20	protein	protein	NN
cord-257558-dgnbfzli	39	21	and	and	CC
cord-257558-dgnbfzli	39	22	activation	activation	NN
cord-257558-dgnbfzli	39	23	of	of	IN
cord-257558-dgnbfzli	39	24	TACE	TACE	NNP
cord-257558-dgnbfzli	39	25	.	.	.
cord-257558-dgnbfzli	40	1	Indeed	indeed	RB
cord-257558-dgnbfzli	40	2	,	,	,
cord-257558-dgnbfzli	40	3	ACE2	ACE2	NNP
cord-257558-dgnbfzli	40	4	deficiency	deficiency	NN
cord-257558-dgnbfzli	40	5	exacerbates	exacerbate	VBZ
cord-257558-dgnbfzli	40	6	disease	disease	NN
cord-257558-dgnbfzli	40	7	in	in	IN
cord-257558-dgnbfzli	40	8	mouse	mouse	NN
cord-257558-dgnbfzli	40	9	models	model	NNS
cord-257558-dgnbfzli	40	10	of	of	IN
cord-257558-dgnbfzli	40	11	methicillin	methicillin	NN
cord-257558-dgnbfzli	40	12	-	-	HYPH
cord-257558-dgnbfzli	40	13	resistant	resistant	JJ
cord-257558-dgnbfzli	40	14	Staphylococcus	Staphylococcus	NNP
cord-257558-dgnbfzli	40	15	aureus	aureus	NN
cord-257558-dgnbfzli	40	16	and	and	CC
cord-257558-dgnbfzli	40	17	two	two	CD
cord-257558-dgnbfzli	40	18	strains	strain	NNS
cord-257558-dgnbfzli	40	19	of	of	IN
cord-257558-dgnbfzli	40	20	influenza	influenza	NN
cord-257558-dgnbfzli	40	21	(	(	-LRB-
cord-257558-dgnbfzli	40	22	Khan	Khan	NNP
cord-257558-dgnbfzli	40	23	et	et	NNP
cord-257558-dgnbfzli	40	24	al	al	NNP
cord-257558-dgnbfzli	40	25	.	.	NNP
cord-257558-dgnbfzli	40	26	,	,	,
cord-257558-dgnbfzli	40	27	2017	2017	CD
cord-257558-dgnbfzli	40	28	;	;	.
cord-257558-dgnbfzli	41	1	Yang	Yang	NNP
cord-257558-dgnbfzli	41	2	et	et	NNP
cord-257558-dgnbfzli	41	3	al	al	NNP
cord-257558-dgnbfzli	41	4	.	.	.
cord-257558-dgnbfzli	42	1	,	,	,
cord-257558-dgnbfzli	42	2	2014	2014	CD
cord-257558-dgnbfzli	42	3	;	;	:
cord-257558-dgnbfzli	42	4	Zou	Zou	NNP
cord-257558-dgnbfzli	42	5	et	et	FW
cord-257558-dgnbfzli	42	6	al	al	NNP
cord-257558-dgnbfzli	42	7	.	.	NNP
cord-257558-dgnbfzli	42	8	,	,	,
cord-257558-dgnbfzli	42	9	2014	2014	CD
cord-257558-dgnbfzli	42	10	)	)	-RRB-
cord-257558-dgnbfzli	42	11	.	.	.
cord-257558-dgnbfzli	43	1	In	in	IN
cord-257558-dgnbfzli	43	2	patients	patient	NNS
cord-257558-dgnbfzli	43	3	infected	infect	VBN
cord-257558-dgnbfzli	43	4	with	with	IN
cord-257558-dgnbfzli	43	5	H5N1	H5N1	NNP
cord-257558-dgnbfzli	43	6	bird	bird	NN
cord-257558-dgnbfzli	43	7	flu	flu	NN
cord-257558-dgnbfzli	43	8	,	,	,
cord-257558-dgnbfzli	43	9	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	43	10	II	ii	CD
cord-257558-dgnbfzli	43	11	levels	level	NNS
cord-257558-dgnbfzli	43	12	rise	rise	VBP
cord-257558-dgnbfzli	43	13	,	,	,
cord-257558-dgnbfzli	43	14	with	with	IN
cord-257558-dgnbfzli	43	15	high	high	JJ
cord-257558-dgnbfzli	43	16	levels	level	NNS
cord-257558-dgnbfzli	43	17	associated	associate	VBN
cord-257558-dgnbfzli	43	18	with	with	IN
cord-257558-dgnbfzli	43	19	greater	great	JJR
cord-257558-dgnbfzli	43	20	disease	disease	NN
cord-257558-dgnbfzli	43	21	severity	severity	NN
cord-257558-dgnbfzli	43	22	.	.	.
cord-257558-dgnbfzli	44	1	Similarly	similarly	RB
cord-257558-dgnbfzli	44	2	,	,	,
cord-257558-dgnbfzli	44	3	in	in	IN
cord-257558-dgnbfzli	44	4	mice	mouse	NNS
cord-257558-dgnbfzli	44	5	infected	infect	VBN
cord-257558-dgnbfzli	44	6	with	with	IN
cord-257558-dgnbfzli	44	7	H5N1	H5N1	NNP
cord-257558-dgnbfzli	44	8	,	,	,
cord-257558-dgnbfzli	44	9	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	44	10	II	ii	CD
cord-257558-dgnbfzli	44	11	levels	level	NNS
cord-257558-dgnbfzli	44	12	predict	predict	VBP
cord-257558-dgnbfzli	44	13	outcome	outcome	NN
cord-257558-dgnbfzli	44	14	,	,	,
cord-257558-dgnbfzli	44	15	and	and	CC
cord-257558-dgnbfzli	44	16	ACE2	ACE2	NNP
cord-257558-dgnbfzli	44	17	deficiency	deficiency	NN
cord-257558-dgnbfzli	44	18	leads	lead	VBZ
cord-257558-dgnbfzli	44	19	to	to	IN
cord-257558-dgnbfzli	44	20	greater	great	JJR
cord-257558-dgnbfzli	44	21	mortality	mortality	NN
cord-257558-dgnbfzli	44	22	(	(	-LRB-
cord-257558-dgnbfzli	44	23	Zou	Zou	NNP
cord-257558-dgnbfzli	44	24	et	et	FW
cord-257558-dgnbfzli	44	25	al	al	NNP
cord-257558-dgnbfzli	44	26	.	.	NNP
cord-257558-dgnbfzli	44	27	,	,	,
cord-257558-dgnbfzli	44	28	2014	2014	CD
cord-257558-dgnbfzli	44	29	)	)	-RRB-
cord-257558-dgnbfzli	44	30	.	.	.
cord-257558-dgnbfzli	45	1	In	in	IN
cord-257558-dgnbfzli	45	2	mice	mouse	NNS
cord-257558-dgnbfzli	45	3	infected	infect	VBN
cord-257558-dgnbfzli	45	4	with	with	IN
cord-257558-dgnbfzli	45	5	H5N9	H5N9	NNP
cord-257558-dgnbfzli	45	6	,	,	,
cord-257558-dgnbfzli	45	7	ACE2	ACE2	NNP
cord-257558-dgnbfzli	45	8	deficiency	deficiency	NN
cord-257558-dgnbfzli	45	9	also	also	RB
cord-257558-dgnbfzli	45	10	leads	lead	VBZ
cord-257558-dgnbfzli	45	11	to	to	IN
cord-257558-dgnbfzli	45	12	more	more	RBR
cord-257558-dgnbfzli	45	13	severe	severe	JJ
cord-257558-dgnbfzli	45	14	disease	disease	NN
cord-257558-dgnbfzli	45	15	.	.	.
cord-257558-dgnbfzli	46	1	Angiotensin	angiotensin	NN
cord-257558-dgnbfzli	46	2	,	,	,
cord-257558-dgnbfzli	46	3	not	not	RB
cord-257558-dgnbfzli	46	4	cleaved	cleave	VBN
cord-257558-dgnbfzli	46	5	by	by	IN
cord-257558-dgnbfzli	46	6	ACE2	ACE2	NNP
cord-257558-dgnbfzli	46	7	,	,	,
cord-257558-dgnbfzli	46	8	binds	bind	VBZ
cord-257558-dgnbfzli	46	9	the	the	DT
cord-257558-dgnbfzli	46	10	AT1	AT1	NNP
cord-257558-dgnbfzli	46	11	receptor	receptor	NN
cord-257558-dgnbfzli	46	12	,	,	,
cord-257558-dgnbfzli	46	13	contributing	contribute	VBG
cord-257558-dgnbfzli	46	14	to	to	IN
cord-257558-dgnbfzli	46	15	pathology	pathology	NN
cord-257558-dgnbfzli	46	16	;	;	:
cord-257558-dgnbfzli	46	17	an	an	DT
cord-257558-dgnbfzli	46	18	AT1	at1	NN
cord-257558-dgnbfzli	46	19	receptor	receptor	NN
cord-257558-dgnbfzli	46	20	inhibitor	inhibitor	NN
cord-257558-dgnbfzli	46	21	,	,	,
cord-257558-dgnbfzli	46	22	losartan	losartan	NNP
cord-257558-dgnbfzli	46	23	,	,	,
cord-257558-dgnbfzli	46	24	improves	improve	VBZ
cord-257558-dgnbfzli	46	25	disease	disease	NNP
cord-257558-dgnbfzli	46	26	outcome	outcome	NN
cord-257558-dgnbfzli	47	1	(	(	-LRB-
cord-257558-dgnbfzli	47	2	Yang	Yang	NNP
cord-257558-dgnbfzli	47	3	et	et	NNP
cord-257558-dgnbfzli	47	4	al	al	NNP
cord-257558-dgnbfzli	47	5	.	.	NNP
cord-257558-dgnbfzli	47	6	,	,	,
cord-257558-dgnbfzli	47	7	2014	2014	CD
cord-257558-dgnbfzli	47	8	)	)	-RRB-
cord-257558-dgnbfzli	47	9	.	.	.
cord-257558-dgnbfzli	48	1	Interestingly	interestingly	RB
cord-257558-dgnbfzli	48	2	,	,	,
cord-257558-dgnbfzli	48	3	in	in	IN
cord-257558-dgnbfzli	48	4	a	a	DT
cord-257558-dgnbfzli	48	5	mouse	mouse	NN
cord-257558-dgnbfzli	48	6	model	model	NN
cord-257558-dgnbfzli	48	7	of	of	IN
cord-257558-dgnbfzli	48	8	Pseudomonas	Pseudomonas	NNP
cord-257558-dgnbfzli	48	9	aeruginosa	aeruginosa	NN
cord-257558-dgnbfzli	48	10	infection	infection	NN
cord-257558-dgnbfzli	48	11	,	,	,
cord-257558-dgnbfzli	48	12	a	a	DT
cord-257558-dgnbfzli	48	13	deficiency	deficiency	NN
cord-257558-dgnbfzli	48	14	of	of	IN
cord-257558-dgnbfzli	48	15	ACE2	ACE2	NNP
cord-257558-dgnbfzli	48	16	function	function	NN
cord-257558-dgnbfzli	48	17	leads	lead	VBZ
cord-257558-dgnbfzli	48	18	to	to	IN
cord-257558-dgnbfzli	48	19	increased	increase	VBN
cord-257558-dgnbfzli	48	20	neutrophil	neutrophil	NN
cord-257558-dgnbfzli	48	21	accumulation	accumulation	NN
cord-257558-dgnbfzli	48	22	in	in	IN
cord-257558-dgnbfzli	48	23	the	the	DT
cord-257558-dgnbfzli	48	24	lung	lung	NN
cord-257558-dgnbfzli	48	25	through	through	IN
cord-257558-dgnbfzli	48	26	an	an	DT
cord-257558-dgnbfzli	48	27	IL-17-dependent	IL-17-dependent	NNP
cord-257558-dgnbfzli	48	28	pathway	pathway	NN
cord-257558-dgnbfzli	48	29	(	(	-LRB-
cord-257558-dgnbfzli	48	30	Sodhi	Sodhi	NNP
cord-257558-dgnbfzli	48	31	et	et	NNP
cord-257558-dgnbfzli	48	32	al	al	NNP
cord-257558-dgnbfzli	48	33	.	.	NNP
cord-257558-dgnbfzli	48	34	,	,	,
cord-257558-dgnbfzli	48	35	2019	2019	CD
cord-257558-dgnbfzli	48	36	)	)	-RRB-
cord-257558-dgnbfzli	48	37	.	.	.
cord-257558-dgnbfzli	49	1	The	the	DT
cord-257558-dgnbfzli	49	2	increased	increase	VBN
cord-257558-dgnbfzli	49	3	TF	tf	NN
cord-257558-dgnbfzli	49	4	in	in	IN
cord-257558-dgnbfzli	49	5	endothelial	endothelial	JJ
cord-257558-dgnbfzli	49	6	cells	cell	NNS
cord-257558-dgnbfzli	49	7	leads	lead	VBZ
cord-257558-dgnbfzli	49	8	to	to	IN
cord-257558-dgnbfzli	49	9	thrombosis	thrombosis	NN
cord-257558-dgnbfzli	49	10	,	,	,
cord-257558-dgnbfzli	49	11	which	which	WDT
cord-257558-dgnbfzli	49	12	is	be	VBZ
cord-257558-dgnbfzli	49	13	present	present	JJ
cord-257558-dgnbfzli	49	14	in	in	IN
cord-257558-dgnbfzli	49	15	numerous	numerous	JJ
cord-257558-dgnbfzli	49	16	hospitalized	hospitalize	VBN
cord-257558-dgnbfzli	49	17	COVID-19	covid-19	CD
cord-257558-dgnbfzli	49	18	patients	patient	NNS
cord-257558-dgnbfzli	50	1	(	(	-LRB-
cord-257558-dgnbfzli	50	2	Bikdeli	Bikdeli	NNP
cord-257558-dgnbfzli	50	3	et	et	NNP
cord-257558-dgnbfzli	50	4	al	al	NNP
cord-257558-dgnbfzli	50	5	.	.	.
cord-257558-dgnbfzli	51	1	,	,	,
cord-257558-dgnbfzli	51	2	2020	2020	CD
cord-257558-dgnbfzli	51	3	;	;	:
cord-257558-dgnbfzli	51	4	Klok	Klok	NNP
cord-257558-dgnbfzli	51	5	et	et	NNP
cord-257558-dgnbfzli	51	6	al	al	NNP
cord-257558-dgnbfzli	51	7	.	.	NNP
cord-257558-dgnbfzli	51	8	,	,	,
cord-257558-dgnbfzli	51	9	2020	2020	CD
cord-257558-dgnbfzli	51	10	)	)	-RRB-
cord-257558-dgnbfzli	51	11	.	.	.
cord-257558-dgnbfzli	52	1	The	the	DT
cord-257558-dgnbfzli	52	2	increased	increase	VBN
cord-257558-dgnbfzli	52	3	aldosterone	aldosterone	NN
cord-257558-dgnbfzli	52	4	may	may	MD
cord-257558-dgnbfzli	52	5	be	be	VB
cord-257558-dgnbfzli	52	6	responsible	responsible	JJ
cord-257558-dgnbfzli	52	7	for	for	IN
cord-257558-dgnbfzli	52	8	the	the	DT
cord-257558-dgnbfzli	52	9	hypokalemia	hypokalemia	NN
cord-257558-dgnbfzli	52	10	seen	see	VBN
cord-257558-dgnbfzli	52	11	in	in	IN
cord-257558-dgnbfzli	52	12	many	many	JJ
cord-257558-dgnbfzli	52	13	COVID-19	covid-19	JJ
cord-257558-dgnbfzli	52	14	patients	patient	NNS
cord-257558-dgnbfzli	52	15	.	.	.
cord-257558-dgnbfzli	53	1	More	more	RBR
cord-257558-dgnbfzli	53	2	speculatively	speculatively	RB
cord-257558-dgnbfzli	53	3	,	,	,
cord-257558-dgnbfzli	53	4	while	while	IN
cord-257558-dgnbfzli	53	5	the	the	DT
cord-257558-dgnbfzli	53	6	inflammatory	inflammatory	JJ
cord-257558-dgnbfzli	53	7	arm	arm	NN
cord-257558-dgnbfzli	53	8	of	of	IN
cord-257558-dgnbfzli	53	9	the	the	DT
cord-257558-dgnbfzli	53	10	RAS	RAS	NNP
cord-257558-dgnbfzli	53	11	produces	produce	VBZ
cord-257558-dgnbfzli	53	12	TNF	TNF	NNP
cord-257558-dgnbfzli	53	13	,	,	,
cord-257558-dgnbfzli	53	14	IL-6	IL-6	NNP
cord-257558-dgnbfzli	53	15	,	,	,
cord-257558-dgnbfzli	53	16	and	and	CC
cord-257558-dgnbfzli	53	17	other	other	JJ
cord-257558-dgnbfzli	53	18	pro	pro	JJ
cord-257558-dgnbfzli	53	19	-	-	JJ
cord-257558-dgnbfzli	53	20	inflammatory	inflammatory	JJ
cord-257558-dgnbfzli	53	21	cytokines	cytokine	NNS
cord-257558-dgnbfzli	53	22	without	without	IN
cord-257558-dgnbfzli	53	23	producing	produce	VBG
cord-257558-dgnbfzli	53	24	interferon	interferon	NN
cord-257558-dgnbfzli	53	25	,	,	,
cord-257558-dgnbfzli	53	26	ACE	ACE	NNP
cord-257558-dgnbfzli	53	27	cleaves	cleave	VBZ
cord-257558-dgnbfzli	53	28	bradykinin	bradykinin	NN
cord-257558-dgnbfzli	53	29	,	,	,
cord-257558-dgnbfzli	53	30	a	a	DT
cord-257558-dgnbfzli	53	31	known	know	VBN
cord-257558-dgnbfzli	53	32	suppressor	suppressor	NN
cord-257558-dgnbfzli	53	33	of	of	IN
cord-257558-dgnbfzli	53	34	interferon	interferon	NN
cord-257558-dgnbfzli	53	35	,	,	,
cord-257558-dgnbfzli	53	36	and	and	CC
cord-257558-dgnbfzli	53	37	so	so	RB
cord-257558-dgnbfzli	53	38	might	may	MD
cord-257558-dgnbfzli	53	39	lead	lead	VB
cord-257558-dgnbfzli	53	40	to	to	IN
cord-257558-dgnbfzli	53	41	increased	increase	VBN
cord-257558-dgnbfzli	53	42	interferon	interferon	NN
cord-257558-dgnbfzli	53	43	in	in	IN
cord-257558-dgnbfzli	53	44	some	some	DT
cord-257558-dgnbfzli	53	45	individuals	individual	NNS
cord-257558-dgnbfzli	53	46	(	(	-LRB-
cord-257558-dgnbfzli	53	47	Seliga	Seliga	NNP
cord-257558-dgnbfzli	53	48	et	et	NNP
cord-257558-dgnbfzli	53	49	al	al	NNP
cord-257558-dgnbfzli	53	50	.	.	NNP
cord-257558-dgnbfzli	53	51	,	,	,
cord-257558-dgnbfzli	53	52	2018	2018	CD
cord-257558-dgnbfzli	53	53	)	)	-RRB-
cord-257558-dgnbfzli	53	54	.	.	.
cord-257558-dgnbfzli	54	1	Some	some	DT
cord-257558-dgnbfzli	54	2	individuals	individual	NNS
cord-257558-dgnbfzli	54	3	with	with	IN
cord-257558-dgnbfzli	54	4	a	a	DT
cord-257558-dgnbfzli	54	5	particular	particular	JJ
cord-257558-dgnbfzli	54	6	genetic	genetic	JJ
cord-257558-dgnbfzli	54	7	predisposition	predisposition	NN
cord-257558-dgnbfzli	54	8	may	may	MD
cord-257558-dgnbfzli	54	9	produce	produce	VB
cord-257558-dgnbfzli	54	10	high	high	JJ
cord-257558-dgnbfzli	54	11	levels	level	NNS
cord-257558-dgnbfzli	54	12	of	of	IN
cord-257558-dgnbfzli	54	13	interferon	interferon	NN
cord-257558-dgnbfzli	54	14	,	,	,
cord-257558-dgnbfzli	54	15	and	and	CC
cord-257558-dgnbfzli	54	16	these	these	DT
cord-257558-dgnbfzli	54	17	may	may	MD
cord-257558-dgnbfzli	54	18	be	be	VB
cord-257558-dgnbfzli	54	19	the	the	DT
cord-257558-dgnbfzli	54	20	individuals	individual	NNS
cord-257558-dgnbfzli	54	21	who	who	WP
cord-257558-dgnbfzli	54	22	develop	develop	VBP
cord-257558-dgnbfzli	54	23	"	"	``
cord-257558-dgnbfzli	54	24	COVID	COVID	NNP
cord-257558-dgnbfzli	54	25	toes	toe	NNS
cord-257558-dgnbfzli	54	26	"	"	''
cord-257558-dgnbfzli	54	27	(	(	-LRB-
cord-257558-dgnbfzli	54	28	Landa	Landa	NNP
cord-257558-dgnbfzli	54	29	et	et	NNP
cord-257558-dgnbfzli	54	30	al	al	NNP
cord-257558-dgnbfzli	54	31	.	.	NNP
cord-257558-dgnbfzli	54	32	,	,	,
cord-257558-dgnbfzli	54	33	2020	2020	CD
cord-257558-dgnbfzli	54	34	;	;	.
cord-257558-dgnbfzli	55	1	Zhang	Zhang	NNP
cord-257558-dgnbfzli	55	2	et	et	NNP
cord-257558-dgnbfzli	55	3	al	al	NNP
cord-257558-dgnbfzli	55	4	.	.	NNP
cord-257558-dgnbfzli	55	5	,	,	,
cord-257558-dgnbfzli	55	6	2020	2020	CD
cord-257558-dgnbfzli	55	7	)	)	-RRB-
cord-257558-dgnbfzli	55	8	.	.	.
cord-257558-dgnbfzli	56	1	This	this	DT
cord-257558-dgnbfzli	56	2	predisposition	predisposition	NN
cord-257558-dgnbfzli	56	3	may	may	MD
cord-257558-dgnbfzli	56	4	include	include	VB
cord-257558-dgnbfzli	56	5	those	those	DT
cord-257558-dgnbfzli	56	6	genes	gene	NNS
cord-257558-dgnbfzli	56	7	with	with	IN
cord-257558-dgnbfzli	56	8	risk	risk	NN
cord-257558-dgnbfzli	56	9	alleles	allele	NNS
cord-257558-dgnbfzli	56	10	in	in	IN
cord-257558-dgnbfzli	56	11	systemic	systemic	JJ
cord-257558-dgnbfzli	56	12	lupus	lupus	NN
cord-257558-dgnbfzli	56	13	erythematosus	erythematosus	NN
cord-257558-dgnbfzli	56	14	(	(	-LRB-
cord-257558-dgnbfzli	56	15	SLE	SLE	NNP
cord-257558-dgnbfzli	56	16	)	)	-RRB-
cord-257558-dgnbfzli	56	17	that	that	WDT
cord-257558-dgnbfzli	56	18	have	have	VBP
cord-257558-dgnbfzli	56	19	a	a	DT
cord-257558-dgnbfzli	56	20	propensity	propensity	NN
cord-257558-dgnbfzli	56	21	for	for	IN
cord-257558-dgnbfzli	56	22	high	high	JJ
cord-257558-dgnbfzli	56	23	interferon	interferon	NN
cord-257558-dgnbfzli	56	24	production	production	NN
cord-257558-dgnbfzli	56	25	(	(	-LRB-
cord-257558-dgnbfzli	56	26	Ghodke	Ghodke	NNP
cord-257558-dgnbfzli	56	27	-	-	HYPH
cord-257558-dgnbfzli	56	28	Puranik	Puranik	NNP
cord-257558-dgnbfzli	56	29	and	and	CC
cord-257558-dgnbfzli	56	30	Niewold	Niewold	NNP
cord-257558-dgnbfzli	56	31	,	,	,
cord-257558-dgnbfzli	56	32	2015	2015	CD
cord-257558-dgnbfzli	56	33	)	)	-RRB-
cord-257558-dgnbfzli	56	34	.	.	.
cord-257558-dgnbfzli	57	1	Interestingly	interestingly	RB
cord-257558-dgnbfzli	57	2	,	,	,
cord-257558-dgnbfzli	57	3	low	low	JJ
cord-257558-dgnbfzli	57	4	interferon	interferon	NN
cord-257558-dgnbfzli	57	5	is	be	VBZ
cord-257558-dgnbfzli	57	6	seen	see	VBN
cord-257558-dgnbfzli	57	7	in	in	IN
cord-257558-dgnbfzli	57	8	many	many	JJ
cord-257558-dgnbfzli	57	9	COVID-19	covid-19	JJ
cord-257558-dgnbfzli	57	10	patients	patient	NNS
cord-257558-dgnbfzli	57	11	and	and	CC
cord-257558-dgnbfzli	57	12	is	be	VBZ
cord-257558-dgnbfzli	57	13	more	more	RBR
cord-257558-dgnbfzli	57	14	consistent	consistent	JJ
cord-257558-dgnbfzli	57	15	with	with	IN
cord-257558-dgnbfzli	57	16	activation	activation	NN
cord-257558-dgnbfzli	57	17	of	of	IN
cord-257558-dgnbfzli	57	18	the	the	DT
cord-257558-dgnbfzli	57	19	RAS	RAS	NNP
cord-257558-dgnbfzli	57	20	pathway	pathway	NN
cord-257558-dgnbfzli	57	21	than	than	IN
cord-257558-dgnbfzli	57	22	activation	activation	NN
cord-257558-dgnbfzli	57	23	of	of	IN
cord-257558-dgnbfzli	57	24	TLRs	TLRs	NNP
cord-257558-dgnbfzli	58	1	(	(	-LRB-
cord-257558-dgnbfzli	58	2	Hadjadj	Hadjadj	NNP
cord-257558-dgnbfzli	58	3	et	et	NNP
cord-257558-dgnbfzli	58	4	al	al	NNP
cord-257558-dgnbfzli	58	5	.	.	.
cord-257558-dgnbfzli	59	1	,	,	,
cord-257558-dgnbfzli	59	2	2020	2020	CD
cord-257558-dgnbfzli	59	3	Preprint	Preprint	NNP
cord-257558-dgnbfzli	59	4	)	)	-RRB-
cord-257558-dgnbfzli	59	5	.	.	.
cord-257558-dgnbfzli	60	1	TLR	TLR	NNP
cord-257558-dgnbfzli	60	2	activation	activation	NN
cord-257558-dgnbfzli	60	3	induces	induce	VBZ
cord-257558-dgnbfzli	60	4	interferon	interferon	NN
cord-257558-dgnbfzli	60	5	;	;	:
cord-257558-dgnbfzli	60	6	activation	activation	NN
cord-257558-dgnbfzli	60	7	of	of	IN
cord-257558-dgnbfzli	60	8	AT1	at1	NN
cord-257558-dgnbfzli	60	9	by	by	IN
cord-257558-dgnbfzli	60	10	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	60	11	II	II	NNP
cord-257558-dgnbfzli	60	12	,	,	,
cord-257558-dgnbfzli	60	13	in	in	IN
cord-257558-dgnbfzli	60	14	contrast	contrast	NN
cord-257558-dgnbfzli	60	15	,	,	,
cord-257558-dgnbfzli	60	16	leads	lead	VBZ
cord-257558-dgnbfzli	60	17	to	to	IN
cord-257558-dgnbfzli	60	18	proinflammatory	proinflammatory	JJ
cord-257558-dgnbfzli	60	19	cytokines	cytokine	NNS
cord-257558-dgnbfzli	60	20	but	but	CC
cord-257558-dgnbfzli	60	21	not	not	RB
cord-257558-dgnbfzli	60	22	interferon	interferon	JJ
cord-257558-dgnbfzli	61	1	(	(	-LRB-
cord-257558-dgnbfzli	61	2	Meng	Meng	NNP
cord-257558-dgnbfzli	61	3	et	et	FW
cord-257558-dgnbfzli	61	4	al	al	NNP
cord-257558-dgnbfzli	61	5	.	.	NNP
cord-257558-dgnbfzli	61	6	,	,	,
cord-257558-dgnbfzli	61	7	2017	2017	CD
cord-257558-dgnbfzli	61	8	)	)	-RRB-
cord-257558-dgnbfzli	61	9	.	.	.
cord-257558-dgnbfzli	62	1	There	there	EX
cord-257558-dgnbfzli	62	2	are	be	VBP
cord-257558-dgnbfzli	62	3	implications	implication	NNS
cord-257558-dgnbfzli	62	4	of	of	IN
cord-257558-dgnbfzli	62	5	this	this	DT
cord-257558-dgnbfzli	62	6	model	model	NN
cord-257558-dgnbfzli	62	7	.	.	.
cord-257558-dgnbfzli	63	1	First	first	RB
cord-257558-dgnbfzli	63	2	,	,	,
cord-257558-dgnbfzli	63	3	COVID-19	covid-19	JJ
cord-257558-dgnbfzli	63	4	patients	patient	NNS
cord-257558-dgnbfzli	63	5	will	will	MD
cord-257558-dgnbfzli	63	6	have	have	VB
cord-257558-dgnbfzli	63	7	a	a	DT
cord-257558-dgnbfzli	63	8	high	high	JJ
cord-257558-dgnbfzli	63	9	level	level	NN
cord-257558-dgnbfzli	63	10	of	of	IN
cord-257558-dgnbfzli	63	11	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	63	12	II	II	NNP
cord-257558-dgnbfzli	63	13	,	,	,
cord-257558-dgnbfzli	63	14	perhaps	perhaps	RB
cord-257558-dgnbfzli	63	15	even	even	RB
cord-257558-dgnbfzli	63	16	African	African	NNPS
cord-257558-dgnbfzli	63	17	Americans	Americans	NNPS
cord-257558-dgnbfzli	63	18	,	,	,
cord-257558-dgnbfzli	63	19	and	and	CC
cord-257558-dgnbfzli	63	20	a	a	DT
cord-257558-dgnbfzli	63	21	low	low	JJ
cord-257558-dgnbfzli	63	22	level	level	NN
cord-257558-dgnbfzli	63	23	of	of	IN
cord-257558-dgnbfzli	63	24	ang1	ang1	CD
cord-257558-dgnbfzli	63	25	-	-	SYM
cord-257558-dgnbfzli	63	26	7	7	CD
cord-257558-dgnbfzli	63	27	due	due	IN
cord-257558-dgnbfzli	63	28	to	to	IN
cord-257558-dgnbfzli	63	29	the	the	DT
cord-257558-dgnbfzli	63	30	diminished	diminished	JJ
cord-257558-dgnbfzli	63	31	activity	activity	NN
cord-257558-dgnbfzli	63	32	of	of	IN
cord-257558-dgnbfzli	63	33	ACE2	ACE2	NNP
cord-257558-dgnbfzli	63	34	.	.	.
cord-257558-dgnbfzli	64	1	Second	second	RB
cord-257558-dgnbfzli	64	2	,	,	,
cord-257558-dgnbfzli	64	3	those	those	DT
cord-257558-dgnbfzli	64	4	with	with	IN
cord-257558-dgnbfzli	64	5	COVID	COVID	NNP
cord-257558-dgnbfzli	64	6	toes	toe	NNS
cord-257558-dgnbfzli	64	7	may	may	MD
cord-257558-dgnbfzli	64	8	have	have	VB
cord-257558-dgnbfzli	64	9	risk	risk	NN
cord-257558-dgnbfzli	64	10	alleles	allele	NNS
cord-257558-dgnbfzli	64	11	in	in	IN
cord-257558-dgnbfzli	64	12	the	the	DT
cord-257558-dgnbfzli	64	13	interferon	interferon	NN
cord-257558-dgnbfzli	64	14	pathway	pathway	NN
cord-257558-dgnbfzli	64	15	,	,	,
cord-257558-dgnbfzli	64	16	similar	similar	JJ
cord-257558-dgnbfzli	64	17	to	to	IN
cord-257558-dgnbfzli	64	18	some	some	DT
cord-257558-dgnbfzli	64	19	SLE	SLE	NNP
cord-257558-dgnbfzli	64	20	risk	risk	NN
cord-257558-dgnbfzli	64	21	alleles	allele	NNS
cord-257558-dgnbfzli	64	22	,	,	,
cord-257558-dgnbfzli	64	23	as	as	IN
cord-257558-dgnbfzli	64	24	similar	similar	JJ
cord-257558-dgnbfzli	64	25	pathology	pathology	NN
cord-257558-dgnbfzli	64	26	is	be	VBZ
cord-257558-dgnbfzli	64	27	seen	see	VBN
cord-257558-dgnbfzli	64	28	in	in	IN
cord-257558-dgnbfzli	64	29	SLE	SLE	NNP
cord-257558-dgnbfzli	64	30	and	and	CC
cord-257558-dgnbfzli	64	31	interferonopathies	interferonopathies	NNP
cord-257558-dgnbfzli	65	1	(	(	-LRB-
cord-257558-dgnbfzli	65	2	Kolivras	Kolivras	NNP
cord-257558-dgnbfzli	65	3	et	et	NNP
cord-257558-dgnbfzli	65	4	al	al	NNP
cord-257558-dgnbfzli	65	5	.	.	NNP
cord-257558-dgnbfzli	65	6	,	,	,
cord-257558-dgnbfzli	65	7	2020	2020	CD
cord-257558-dgnbfzli	65	8	)	)	-RRB-
cord-257558-dgnbfzli	65	9	.	.	.
cord-257558-dgnbfzli	66	1	High	high	JJ
cord-257558-dgnbfzli	66	2	interferon	interferon	NN
cord-257558-dgnbfzli	66	3	may	may	MD
cord-257558-dgnbfzli	66	4	lead	lead	VB
cord-257558-dgnbfzli	66	5	to	to	IN
cord-257558-dgnbfzli	66	6	an	an	DT
cord-257558-dgnbfzli	66	7	effective	effective	JJ
cord-257558-dgnbfzli	66	8	antiviral	antiviral	JJ
cord-257558-dgnbfzli	66	9	response	response	NN
cord-257558-dgnbfzli	66	10	but	but	CC
cord-257558-dgnbfzli	66	11	also	also	RB
cord-257558-dgnbfzli	66	12	have	have	VBP
cord-257558-dgnbfzli	66	13	the	the	DT
cord-257558-dgnbfzli	66	14	negative	negative	JJ
cord-257558-dgnbfzli	66	15	consequence	consequence	NN
cord-257558-dgnbfzli	66	16	of	of	IN
cord-257558-dgnbfzli	66	17	leading	lead	VBG
cord-257558-dgnbfzli	66	18	to	to	IN
cord-257558-dgnbfzli	66	19	interferon	interferon	NN
cord-257558-dgnbfzli	66	20	-	-	HYPH
cord-257558-dgnbfzli	66	21	induced	induce	VBN
cord-257558-dgnbfzli	66	22	microangiopathy	microangiopathy	NNP
cord-257558-dgnbfzli	66	23	(	(	-LRB-
cord-257558-dgnbfzli	66	24	Massey	Massey	NNP
cord-257558-dgnbfzli	66	25	and	and	CC
cord-257558-dgnbfzli	66	26	Jones	Jones	NNP
cord-257558-dgnbfzli	66	27	,	,	,
cord-257558-dgnbfzli	66	28	2020	2020	CD
cord-257558-dgnbfzli	66	29	)	)	-RRB-
cord-257558-dgnbfzli	66	30	.	.	.
cord-257558-dgnbfzli	67	1	ACE	ACE	NNP
cord-257558-dgnbfzli	67	2	inhibitors	inhibitor	NNS
cord-257558-dgnbfzli	67	3	might	may	MD
cord-257558-dgnbfzli	67	4	be	be	VB
cord-257558-dgnbfzli	67	5	beneficial	beneficial	JJ
cord-257558-dgnbfzli	67	6	rather	rather	RB
cord-257558-dgnbfzli	67	7	than	than	IN
cord-257558-dgnbfzli	67	8	harmful	harmful	JJ
cord-257558-dgnbfzli	67	9	.	.	.
cord-257558-dgnbfzli	68	1	Angiotensin	angiotensin	NN
cord-257558-dgnbfzli	68	2	receptor	receptor	NN
cord-257558-dgnbfzli	68	3	blockers	blocker	NNS
cord-257558-dgnbfzli	68	4	,	,	,
cord-257558-dgnbfzli	68	5	which	which	WDT
cord-257558-dgnbfzli	68	6	preferentially	preferentially	RB
cord-257558-dgnbfzli	68	7	target	target	VBP
cord-257558-dgnbfzli	68	8	AT1	at1	NN
cord-257558-dgnbfzli	68	9	,	,	,
cord-257558-dgnbfzli	68	10	might	may	MD
cord-257558-dgnbfzli	68	11	also	also	RB
cord-257558-dgnbfzli	68	12	be	be	VB
cord-257558-dgnbfzli	68	13	useful	useful	JJ
cord-257558-dgnbfzli	68	14	.	.	.
cord-257558-dgnbfzli	69	1	While	while	IN
cord-257558-dgnbfzli	69	2	there	there	EX
cord-257558-dgnbfzli	69	3	was	be	VBD
cord-257558-dgnbfzli	69	4	initial	initial	JJ
cord-257558-dgnbfzli	69	5	concern	concern	NN
cord-257558-dgnbfzli	69	6	over	over	IN
cord-257558-dgnbfzli	69	7	the	the	DT
cord-257558-dgnbfzli	69	8	use	use	NN
cord-257558-dgnbfzli	69	9	of	of	IN
cord-257558-dgnbfzli	69	10	these	these	DT
cord-257558-dgnbfzli	69	11	drugs	drug	NNS
cord-257558-dgnbfzli	69	12	,	,	,
cord-257558-dgnbfzli	69	13	as	as	IN
cord-257558-dgnbfzli	69	14	they	-PRON-	PRP
cord-257558-dgnbfzli	69	15	increase	increase	VBP
cord-257558-dgnbfzli	69	16	ACE2	ACE2	NNP
cord-257558-dgnbfzli	69	17	expression	expression	NN
cord-257558-dgnbfzli	69	18	when	when	WRB
cord-257558-dgnbfzli	69	19	used	use	VBN
cord-257558-dgnbfzli	69	20	not	not	RB
cord-257558-dgnbfzli	69	21	in	in	IN
cord-257558-dgnbfzli	69	22	the	the	DT
cord-257558-dgnbfzli	69	23	context	context	NN
cord-257558-dgnbfzli	69	24	of	of	IN
cord-257558-dgnbfzli	69	25	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	69	26	(	(	-LRB-
cord-257558-dgnbfzli	69	27	Vaduganathan	Vaduganathan	NNP
cord-257558-dgnbfzli	69	28	et	et	FW
cord-257558-dgnbfzli	69	29	al	al	NNP
cord-257558-dgnbfzli	69	30	.	.	NNP
cord-257558-dgnbfzli	69	31	,	,	,
cord-257558-dgnbfzli	69	32	2020	2020	CD
cord-257558-dgnbfzli	69	33	)	)	-RRB-
cord-257558-dgnbfzli	69	34	,	,	,
cord-257558-dgnbfzli	69	35	it	-PRON-	PRP
cord-257558-dgnbfzli	69	36	is	be	VBZ
cord-257558-dgnbfzli	69	37	now	now	RB
cord-257558-dgnbfzli	69	38	clear	clear	JJ
cord-257558-dgnbfzli	69	39	they	-PRON-	PRP
cord-257558-dgnbfzli	69	40	are	be	VBP
cord-257558-dgnbfzli	69	41	not	not	RB
cord-257558-dgnbfzli	69	42	harmful	harmful	JJ
cord-257558-dgnbfzli	69	43	in	in	IN
cord-257558-dgnbfzli	69	44	the	the	DT
cord-257558-dgnbfzli	69	45	context	context	NN
cord-257558-dgnbfzli	69	46	of	of	IN
cord-257558-dgnbfzli	69	47	the	the	DT
cord-257558-dgnbfzli	69	48	virus	virus	NN
cord-257558-dgnbfzli	69	49	and	and	CC
cord-257558-dgnbfzli	69	50	may	may	MD
cord-257558-dgnbfzli	69	51	indeed	indeed	RB
cord-257558-dgnbfzli	69	52	be	be	VB
cord-257558-dgnbfzli	69	53	beneficial	beneficial	JJ
cord-257558-dgnbfzli	70	1	(	(	-LRB-
cord-257558-dgnbfzli	70	2	Ghosal	Ghosal	NNP
cord-257558-dgnbfzli	70	3	et	et	NNP
cord-257558-dgnbfzli	70	4	al	al	NNP
cord-257558-dgnbfzli	70	5	.	.	NNP
cord-257558-dgnbfzli	70	6	,	,	,
cord-257558-dgnbfzli	71	1	2020	2020	CD
cord-257558-dgnbfzli	71	2	Preprint	Preprint	NNP
cord-257558-dgnbfzli	71	3	;	;	:
cord-257558-dgnbfzli	71	4	Robertson	Robertson	NNP
cord-257558-dgnbfzli	71	5	,	,	,
cord-257558-dgnbfzli	71	6	2020	2020	CD
cord-257558-dgnbfzli	71	7	)	)	-RRB-
cord-257558-dgnbfzli	71	8	.	.	.
cord-257558-dgnbfzli	72	1	Finally	finally	RB
cord-257558-dgnbfzli	72	2	,	,	,
cord-257558-dgnbfzli	72	3	the	the	DT
cord-257558-dgnbfzli	72	4	use	use	NN
cord-257558-dgnbfzli	72	5	of	of	IN
cord-257558-dgnbfzli	72	6	the	the	DT
cord-257558-dgnbfzli	72	7	ang1	ang1	NNP
cord-257558-dgnbfzli	72	8	-	-	SYM
cord-257558-dgnbfzli	72	9	7	7	CD
cord-257558-dgnbfzli	72	10	peptide	peptide	NN
cord-257558-dgnbfzli	72	11	to	to	TO
cord-257558-dgnbfzli	72	12	counter	counter	VB
cord-257558-dgnbfzli	72	13	the	the	DT
cord-257558-dgnbfzli	72	14	effects	effect	NNS
cord-257558-dgnbfzli	72	15	of	of	IN
cord-257558-dgnbfzli	72	16	the	the	DT
cord-257558-dgnbfzli	72	17	angiotensin	angiotensin	NN
cord-257558-dgnbfzli	72	18	-	-	HYPH
cord-257558-dgnbfzli	72	19	AT1	at1	NN
cord-257558-dgnbfzli	72	20	interaction	interaction	NN
cord-257558-dgnbfzli	72	21	might	may	MD
cord-257558-dgnbfzli	72	22	be	be	VB
cord-257558-dgnbfzli	72	23	a	a	DT
cord-257558-dgnbfzli	72	24	novel	novel	NN
cord-257558-dgnbfzli	72	25	therapeutic	therapeutic	JJ
cord-257558-dgnbfzli	72	26	to	to	TO
cord-257558-dgnbfzli	72	27	pursue	pursue	VB
cord-257558-dgnbfzli	72	28	.	.	.
cord-257558-dgnbfzli	73	1	Figure	figure	NN
cord-257558-dgnbfzli	73	2	1	1	CD
cord-257558-dgnbfzli	73	3	.	.	.
cord-257558-dgnbfzli	74	1	The	the	DT
cord-257558-dgnbfzli	74	2	RAS	RAS	NNP
cord-257558-dgnbfzli	74	3	in	in	IN
cord-257558-dgnbfzli	74	4	health	health	NN
cord-257558-dgnbfzli	74	5	and	and	CC
cord-257558-dgnbfzli	74	6	in	in	IN
cord-257558-dgnbfzli	74	7	SARS	SARS	NNP
cord-257558-dgnbfzli	74	8	-	-	HYPH
cord-257558-dgnbfzli	74	9	CoV-2	CoV-2	NNP
cord-257558-dgnbfzli	74	10	infection	infection	NN
cord-257558-dgnbfzli	74	11	.	.	.
cord-257558-dgnbfzli	75	1	Left	leave	VBN
cord-257558-dgnbfzli	75	2	:	:	:
cord-257558-dgnbfzli	75	3	In	in	IN
cord-257558-dgnbfzli	75	4	a	a	DT
cord-257558-dgnbfzli	75	5	healthy	healthy	JJ
cord-257558-dgnbfzli	75	6	individual	individual	NN
cord-257558-dgnbfzli	75	7	,	,	,
cord-257558-dgnbfzli	75	8	there	there	EX
cord-257558-dgnbfzli	75	9	is	be	VBZ
cord-257558-dgnbfzli	75	10	a	a	DT
cord-257558-dgnbfzli	75	11	balance	balance	NN
cord-257558-dgnbfzli	75	12	of	of	IN
cord-257558-dgnbfzli	75	13	AT1	at1	NN
cord-257558-dgnbfzli	75	14	,	,	,
cord-257558-dgnbfzli	75	15	AT2	at2	NN
cord-257558-dgnbfzli	75	16	,	,	,
cord-257558-dgnbfzli	75	17	and	and	CC
cord-257558-dgnbfzli	75	18	membrane	membrane	NN
cord-257558-dgnbfzli	75	19	-	-	HYPH
cord-257558-dgnbfzli	75	20	bound	bind	VBN
cord-257558-dgnbfzli	75	21	ACE2	ACE2	NNP
cord-257558-dgnbfzli	75	22	with	with	IN
cord-257558-dgnbfzli	75	23	production	production	NN
cord-257558-dgnbfzli	75	24	of	of	IN
cord-257558-dgnbfzli	75	25	ang1	ang1	CD
cord-257558-dgnbfzli	75	26	-	-	SYM
cord-257558-dgnbfzli	75	27	7	7	CD
cord-257558-dgnbfzli	75	28	.	.	.
cord-257558-dgnbfzli	76	1	Aldosterone	Aldosterone	NNP
cord-257558-dgnbfzli	76	2	increases	increase	VBZ
cord-257558-dgnbfzli	76	3	Mas	Mas	NNP
cord-257558-dgnbfzli	76	4	expression	expression	NN
cord-257558-dgnbfzli	76	5	,	,	,
cord-257558-dgnbfzli	76	6	and	and	CC
cord-257558-dgnbfzli	76	7	ang1	ang1	CD
cord-257558-dgnbfzli	76	8	-	-	SYM
cord-257558-dgnbfzli	76	9	7	7	CD
cord-257558-dgnbfzli	76	10	binds	bind	VBZ
cord-257558-dgnbfzli	76	11	Mas	Mas	NNP
cord-257558-dgnbfzli	76	12	to	to	TO
cord-257558-dgnbfzli	76	13	suppress	suppress	VB
cord-257558-dgnbfzli	76	14	inflammation	inflammation	NN
cord-257558-dgnbfzli	76	15	.	.	.
cord-257558-dgnbfzli	77	1	Right	right	RB
cord-257558-dgnbfzli	77	2	:	:	:
cord-257558-dgnbfzli	77	3	In	in	IN
cord-257558-dgnbfzli	77	4	a	a	DT
cord-257558-dgnbfzli	77	5	SARS	SARS	NNP
cord-257558-dgnbfzli	77	6	-	-	HYPH
cord-257558-dgnbfzli	77	7	CoV-2-infected	cov-2-infecte	VBN
cord-257558-dgnbfzli	77	8	individual	individual	NN
cord-257558-dgnbfzli	77	9	,	,	,
cord-257558-dgnbfzli	77	10	there	there	EX
cord-257558-dgnbfzli	77	11	is	be	VBZ
cord-257558-dgnbfzli	77	12	an	an	DT
cord-257558-dgnbfzli	77	13	imbalanced	imbalanced	JJ
cord-257558-dgnbfzli	77	14	RAS	RAS	NNP
cord-257558-dgnbfzli	77	15	,	,	,
cord-257558-dgnbfzli	77	16	with	with	IN
cord-257558-dgnbfzli	77	17	viral	viral	JJ
cord-257558-dgnbfzli	77	18	spike	spike	NN
cord-257558-dgnbfzli	77	19	protein	protein	NN
cord-257558-dgnbfzli	77	20	causing	cause	VBG
cord-257558-dgnbfzli	77	21	ACE2	ACE2	NNP
cord-257558-dgnbfzli	77	22	shedding	shedding	NN
cord-257558-dgnbfzli	77	23	,	,	,
cord-257558-dgnbfzli	77	24	diminished	diminished	JJ
cord-257558-dgnbfzli	77	25	production	production	NN
cord-257558-dgnbfzli	77	26	of	of	IN
cord-257558-dgnbfzli	77	27	ang1	ang1	CD
cord-257558-dgnbfzli	77	28	-	-	SYM
cord-257558-dgnbfzli	77	29	7	7	CD
cord-257558-dgnbfzli	77	30	,	,	,
cord-257558-dgnbfzli	77	31	and	and	CC
cord-257558-dgnbfzli	77	32	high	high	JJ
cord-257558-dgnbfzli	77	33	AT1	at1	NN
cord-257558-dgnbfzli	77	34	with	with	IN
cord-257558-dgnbfzli	77	35	low	low	JJ
cord-257558-dgnbfzli	77	36	AT2	at2	NN
cord-257558-dgnbfzli	77	37	.	.	.
cord-257558-dgnbfzli	78	1	Microbes	microbe	NNS
cord-257558-dgnbfzli	79	1	Infect	infect	VB
cord-257558-dgnbfzli	79	2	ACE	ace	NN
cord-257558-dgnbfzli	79	3	inhibtors	inhibtor	NNS
cord-257558-dgnbfzli	79	4	appear	appear	VBP
cord-257558-dgnbfzli	79	5	to	to	TO
cord-257558-dgnbfzli	79	6	be	be	VB
cord-257558-dgnbfzli	79	7	safe	safe	JJ
cord-257558-dgnbfzli	79	8	and	and	CC
cord-257558-dgnbfzli	79	9	beneficial	beneficial	JJ
cord-257558-dgnbfzli	79	10	for	for	IN
cord-257558-dgnbfzli	79	11	COVID-19	COVID-19	NNP
cord-257558-dgnbfzli	79	12	,	,	,
cord-257558-dgnbfzli	79	13	say	say	VBP
cord-257558-dgnbfzli	79	14	researchers	researcher	NNS
cord-257558-dgnbfzli	79	15	This	this	DT
cord-257558-dgnbfzli	79	16	work	work	NN
cord-257558-dgnbfzli	79	17	was	be	VBD
cord-257558-dgnbfzli	79	18	supported	support	VBN
cord-257558-dgnbfzli	79	19	by	by	IN
cord-257558-dgnbfzli	79	20	grants	grant	NNS
cord-257558-dgnbfzli	79	21	from	from	IN
cord-257558-dgnbfzli	79	22	the	the	DT
cord-257558-dgnbfzli	79	23	National	National	NNP
cord-257558-dgnbfzli	79	24	Institutes	Institutes	NNPS
cord-257558-dgnbfzli	79	25	of	of	IN
cord-257558-dgnbfzli	79	26	Health	Health	NNP
cord-257558-dgnbfzli	79	27	(	(	-LRB-
cord-257558-dgnbfzli	79	28	NIH	NIH	NNP
cord-257558-dgnbfzli	79	29	P01AI073693	P01AI073693	NNP
cord-257558-dgnbfzli	79	30	and	and	CC
cord-257558-dgnbfzli	79	31	NIH	NIH	NNP
cord-257558-dgnbfzli	79	32	R03-AR065157	R03-AR065157	NNP
cord-257558-dgnbfzli	79	33	)	)	-RRB-
cord-257558-dgnbfzli	79	34	.	.	.