id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263167-es806qhz	Rogers, Thomas F.	Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model	2020-06-15		.txt	text/plain	4512	249	53	We showed that passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters, as revealed by maintained weight and low lung viral titers in treated animals. Donor plasma were tested for binding to recombinant SARS-CoV-2 and SARS-CoV-1 S and receptor binding domain (RBD) proteins, for binding to cell surface expressed spikes and for neutralization in both live replicating virus and pseudovirus assays (Fig. 2, B to D, and fig. The bulk-transformed ligation products for both the heavy chain and light chain were transfected and tested for binding to RBD and S protein, and for neutralization in the SARS-CoV-2 pseudovirus assay using HeLa-ACE2 target cells ( fig. To investigate the relationship between in vitro neutralization and protection in vivo against SARS-CoV-2, we selected two mAbs for passive transfer/challenge experiments in a Syrian hamster animal model based on a summary of the nAb data (table S3 and fig.	./cache/cord-263167-es806qhz.txt	./txt/cord-263167-es806qhz.txt