id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312560-onfabcfv	Klingler, J.	Role of IgM and IgA Antibodies to the Neutralization of SARS-CoV-2	2020-08-21		.txt	text/plain	5861	353	55	The data demonstrate high prevalence of spike-and RBD-specific IgM and IgA, similar to that of IgG1, in plasma/serum from COVID-19 patients and their significant contributions to virusneutralizing activities. In Fig. 3 , comparing levels of total Ig with the different Ig isotypes showed a highly significant correlation with IgG1 for both Abs specific for spike and RBD indicating that IgG1 is the major isotype induced by SARS-CoV-2 infection. To ask directly to what extent Abs of different isotypes mediate neutralization, we evaluated the neutralization activities of IgM, IgG, and IgA fractions purified from plasma from five COVID-19-convalescent individuals (RP#1-5). Several SARS-CoV-2 vaccine candidates tested in animal models and humans were shown to induce IgG responses against spike and RBD as well as virus neutralizing activities, but in many of these studies, the induction of other Ig isotypes was not evaluated 46-49 .	./cache/cord-312560-onfabcfv.txt	./txt/cord-312560-onfabcfv.txt