id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342557-a7q8vp8m	Chowdhury, Surid Mohammad	Antiviral Peptides as Promising Therapeutics against SARS-CoV-2	2020-10-23		.txt	text/plain	3554	232	54	[Image: see text] Over 50 peptides, which were known to inhibit SARS-CoV-1, were computationally screened against the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. Peptides that showed higher S protein-binding affinity compared to the α-helix (AH) of the ACE2 peptidase were further analyzed with molecular dynamics (MD) simulation and the structure− activity relationship (SAR) in order to achieve a high-affinity binder for the S protein. 30 Initially, stepwise multiple linear regression (MLR) was performed considering these properties as variables to predict the calculated binding affinity of the test peptides with the RBD of the SARS CoV-2 spike protein. All 51 peptides were docked to the RBD of the SARS CoV-2 spike protein using PatchDock. Various residues including Glu484, Tyr449, and Tyr505 present in the ACE2 binding site of the RBD were involved in noncovalent interaction with the antiviral peptides ( Figure 1a) .	./cache/cord-342557-a7q8vp8m.txt	./txt/cord-342557-a7q8vp8m.txt