id	sid	tid	token	lemma	pos
cord-328189-jpkxjn6e	1	1	key	key	JJ
cord-328189-jpkxjn6e	2	1	:	:	:
cord-328189-jpkxjn6e	2	2	cord-328189-jpkxjn6e	cord-328189-jpkxjn6e	NNS
cord-328189-jpkxjn6e	2	3	authors	author	NNS
cord-328189-jpkxjn6e	2	4	:	:	:
cord-328189-jpkxjn6e	2	5	Brielle	Brielle	NNP
cord-328189-jpkxjn6e	2	6	,	,	,
cord-328189-jpkxjn6e	2	7	Esther	Esther	NNP
cord-328189-jpkxjn6e	2	8	S.	S.	NNP
cord-328189-jpkxjn6e	2	9	;	;	:
cord-328189-jpkxjn6e	2	10	Schneidman	Schneidman	NNP
cord-328189-jpkxjn6e	2	11	-	-	HYPH
cord-328189-jpkxjn6e	2	12	Duhovny	Duhovny	NNP
cord-328189-jpkxjn6e	2	13	,	,	,
cord-328189-jpkxjn6e	2	14	Dina	Dina	NNP
cord-328189-jpkxjn6e	2	15	;	;	:
cord-328189-jpkxjn6e	2	16	Linial	Linial	NNP
cord-328189-jpkxjn6e	2	17	,	,	,
cord-328189-jpkxjn6e	2	18	Michal	Michal	NNP
cord-328189-jpkxjn6e	2	19	title	title	NN
cord-328189-jpkxjn6e	2	20	:	:	:
cord-328189-jpkxjn6e	3	1	The	the	DT
cord-328189-jpkxjn6e	3	2	SARS	SARS	NNP
cord-328189-jpkxjn6e	3	3	-	-	HYPH
cord-328189-jpkxjn6e	3	4	CoV-2	CoV-2	NNP
cord-328189-jpkxjn6e	3	5	exerts	exert	VBZ
cord-328189-jpkxjn6e	3	6	a	a	DT
cord-328189-jpkxjn6e	3	7	distinctive	distinctive	JJ
cord-328189-jpkxjn6e	3	8	strategy	strategy	NN
cord-328189-jpkxjn6e	3	9	for	for	IN
cord-328189-jpkxjn6e	3	10	interacting	interact	VBG
cord-328189-jpkxjn6e	3	11	with	with	IN
cord-328189-jpkxjn6e	3	12	the	the	DT
cord-328189-jpkxjn6e	3	13	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	3	14	human	human	JJ
cord-328189-jpkxjn6e	3	15	receptor	receptor	NN
cord-328189-jpkxjn6e	3	16	date	date	NN
cord-328189-jpkxjn6e	4	1	:	:	:
cord-328189-jpkxjn6e	4	2	2020	2020	CD
cord-328189-jpkxjn6e	4	3	-	-	HYPH
cord-328189-jpkxjn6e	4	4	03	03	CD
cord-328189-jpkxjn6e	4	5	-	-	HYPH
cord-328189-jpkxjn6e	4	6	12	12	CD
cord-328189-jpkxjn6e	4	7	journal	journal	NN
cord-328189-jpkxjn6e	4	8	:	:	:
cord-328189-jpkxjn6e	5	1	bioRxiv	biorxiv	IN
cord-328189-jpkxjn6e	5	2	DOI	DOI	NNP
cord-328189-jpkxjn6e	5	3	:	:	:
cord-328189-jpkxjn6e	6	1	10.1101/2020.03.10.986398	10.1101/2020.03.10.986398	CD
cord-328189-jpkxjn6e	7	1	sha	sha	NNP
cord-328189-jpkxjn6e	7	2	:	:	:
cord-328189-jpkxjn6e	7	3	cb19a324508f3bf37f1c708f263d2e0d6224ad64	cb19a324508f3bf37f1c708f263d2e0d6224ad64	NNP
cord-328189-jpkxjn6e	7	4	doc_id	doc_id	NNP
cord-328189-jpkxjn6e	7	5	:	:	:
cord-328189-jpkxjn6e	7	6	328189	328189	CD
cord-328189-jpkxjn6e	7	7	cord_uid	cord_uid	NN
cord-328189-jpkxjn6e	7	8	:	:	:
cord-328189-jpkxjn6e	8	1	jpkxjn6e	jpkxjn6e	NNP
cord-328189-jpkxjn6e	9	1	The	the	DT
cord-328189-jpkxjn6e	9	2	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	9	3	disease	disease	NN
cord-328189-jpkxjn6e	9	4	has	have	VBZ
cord-328189-jpkxjn6e	9	5	plagued	plague	VBN
cord-328189-jpkxjn6e	9	6	over	over	IN
cord-328189-jpkxjn6e	9	7	110	110	CD
cord-328189-jpkxjn6e	9	8	countries	country	NNS
cord-328189-jpkxjn6e	9	9	and	and	CC
cord-328189-jpkxjn6e	9	10	has	have	VBZ
cord-328189-jpkxjn6e	9	11	resulted	result	VBN
cord-328189-jpkxjn6e	9	12	in	in	IN
cord-328189-jpkxjn6e	9	13	over	over	IN
cord-328189-jpkxjn6e	9	14	4,000	4,000	CD
cord-328189-jpkxjn6e	9	15	deaths	death	NNS
cord-328189-jpkxjn6e	9	16	within	within	IN
cord-328189-jpkxjn6e	9	17	10	10	CD
cord-328189-jpkxjn6e	9	18	weeks	week	NNS
cord-328189-jpkxjn6e	9	19	.	.	.
cord-328189-jpkxjn6e	10	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	10	2	compare	compare	VBP
cord-328189-jpkxjn6e	10	3	the	the	DT
cord-328189-jpkxjn6e	10	4	interaction	interaction	NN
cord-328189-jpkxjn6e	10	5	between	between	IN
cord-328189-jpkxjn6e	10	6	the	the	DT
cord-328189-jpkxjn6e	10	7	human	human	JJ
cord-328189-jpkxjn6e	10	8	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	10	9	receptor	receptor	NN
cord-328189-jpkxjn6e	10	10	and	and	CC
cord-328189-jpkxjn6e	10	11	the	the	DT
cord-328189-jpkxjn6e	10	12	SARS	SARS	NNP
cord-328189-jpkxjn6e	10	13	-	-	HYPH
cord-328189-jpkxjn6e	10	14	CoV-2	CoV-2	NNP
cord-328189-jpkxjn6e	10	15	spike	spike	NN
cord-328189-jpkxjn6e	10	16	protein	protein	NN
cord-328189-jpkxjn6e	10	17	with	with	IN
cord-328189-jpkxjn6e	10	18	that	that	DT
cord-328189-jpkxjn6e	10	19	of	of	IN
cord-328189-jpkxjn6e	10	20	other	other	JJ
cord-328189-jpkxjn6e	10	21	pathogenic	pathogenic	JJ
cord-328189-jpkxjn6e	10	22	coronaviruses	coronaviruse	NNS
cord-328189-jpkxjn6e	10	23	using	use	VBG
cord-328189-jpkxjn6e	10	24	molecular	molecular	JJ
cord-328189-jpkxjn6e	10	25	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	10	26	simulations	simulation	NNS
cord-328189-jpkxjn6e	10	27	.	.	.
cord-328189-jpkxjn6e	11	1	SARS	SARS	NNP
cord-328189-jpkxjn6e	11	2	-	-	HYPH
cord-328189-jpkxjn6e	11	3	CoV	CoV	NNP
cord-328189-jpkxjn6e	11	4	,	,	,
cord-328189-jpkxjn6e	11	5	SARS	SARS	NNP
cord-328189-jpkxjn6e	11	6	-	-	HYPH
cord-328189-jpkxjn6e	11	7	CoV-2	CoV-2	NNP
cord-328189-jpkxjn6e	11	8	,	,	,
cord-328189-jpkxjn6e	11	9	and	and	CC
cord-328189-jpkxjn6e	11	10	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	11	11	-	-	:
cord-328189-jpkxjn6e	11	12	NL63	NL63	NNP
cord-328189-jpkxjn6e	11	13	recognize	recognize	VB
cord-328189-jpkxjn6e	11	14	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	11	15	as	as	IN
cord-328189-jpkxjn6e	11	16	the	the	DT
cord-328189-jpkxjn6e	11	17	natural	natural	JJ
cord-328189-jpkxjn6e	11	18	receptor	receptor	NN
cord-328189-jpkxjn6e	11	19	but	but	CC
cord-328189-jpkxjn6e	11	20	present	present	VB
cord-328189-jpkxjn6e	11	21	a	a	DT
cord-328189-jpkxjn6e	11	22	distinct	distinct	JJ
cord-328189-jpkxjn6e	11	23	binding	bind	VBG
cord-328189-jpkxjn6e	11	24	interface	interface	NN
cord-328189-jpkxjn6e	11	25	to	to	IN
cord-328189-jpkxjn6e	11	26	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	11	27	and	and	CC
cord-328189-jpkxjn6e	11	28	a	a	DT
cord-328189-jpkxjn6e	11	29	different	different	JJ
cord-328189-jpkxjn6e	11	30	network	network	NN
cord-328189-jpkxjn6e	11	31	of	of	IN
cord-328189-jpkxjn6e	11	32	residue	residue	NN
cord-328189-jpkxjn6e	11	33	-	-	HYPH
cord-328189-jpkxjn6e	11	34	residue	residue	NN
cord-328189-jpkxjn6e	11	35	contacts	contact	NNS
cord-328189-jpkxjn6e	11	36	.	.	.
cord-328189-jpkxjn6e	12	1	SARS	SARS	NNP
cord-328189-jpkxjn6e	12	2	-	-	HYPH
cord-328189-jpkxjn6e	12	3	CoV	CoV	NNP
cord-328189-jpkxjn6e	12	4	and	and	CC
cord-328189-jpkxjn6e	12	5	SARS	SARS	NNP
cord-328189-jpkxjn6e	12	6	-	-	HYPH
cord-328189-jpkxjn6e	12	7	CoV-2	CoV-2	NNP
cord-328189-jpkxjn6e	12	8	have	have	VBP
cord-328189-jpkxjn6e	12	9	comparable	comparable	JJ
cord-328189-jpkxjn6e	12	10	binding	bind	VBG
cord-328189-jpkxjn6e	12	11	affinities	affinity	NNS
cord-328189-jpkxjn6e	12	12	achieved	achieve	VBN
cord-328189-jpkxjn6e	12	13	by	by	IN
cord-328189-jpkxjn6e	12	14	balancing	balance	VBG
cord-328189-jpkxjn6e	12	15	energetics	energetic	NNS
cord-328189-jpkxjn6e	12	16	and	and	CC
cord-328189-jpkxjn6e	12	17	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	12	18	.	.	.
cord-328189-jpkxjn6e	13	1	The	the	DT
cord-328189-jpkxjn6e	13	2	SARS	SARS	NNP
cord-328189-jpkxjn6e	13	3	-	-	HYPH
cord-328189-jpkxjn6e	13	4	CoV-2–ACE2	CoV-2–ACE2	NNP
cord-328189-jpkxjn6e	13	5	complex	complex	NN
cord-328189-jpkxjn6e	13	6	contains	contain	VBZ
cord-328189-jpkxjn6e	13	7	a	a	DT
cord-328189-jpkxjn6e	13	8	higher	high	JJR
cord-328189-jpkxjn6e	13	9	number	number	NN
cord-328189-jpkxjn6e	13	10	of	of	IN
cord-328189-jpkxjn6e	13	11	contacts	contact	NNS
cord-328189-jpkxjn6e	13	12	,	,	,
cord-328189-jpkxjn6e	13	13	a	a	DT
cord-328189-jpkxjn6e	13	14	larger	large	JJR
cord-328189-jpkxjn6e	13	15	interface	interface	NN
cord-328189-jpkxjn6e	13	16	area	area	NN
cord-328189-jpkxjn6e	13	17	,	,	,
cord-328189-jpkxjn6e	13	18	and	and	CC
cord-328189-jpkxjn6e	13	19	decreased	decrease	VBD
cord-328189-jpkxjn6e	13	20	interface	interface	NN
cord-328189-jpkxjn6e	13	21	residue	residue	NN
cord-328189-jpkxjn6e	13	22	fluctuations	fluctuation	NNS
cord-328189-jpkxjn6e	13	23	relative	relative	JJ
cord-328189-jpkxjn6e	13	24	to	to	IN
cord-328189-jpkxjn6e	13	25	SARS-	sars-	VB
cord-328189-jpkxjn6e	14	1	CoV.	CoV.	NNP
cord-328189-jpkxjn6e	15	1	These	these	DT
cord-328189-jpkxjn6e	15	2	findings	finding	NNS
cord-328189-jpkxjn6e	15	3	expose	expose	VBP
cord-328189-jpkxjn6e	15	4	an	an	DT
cord-328189-jpkxjn6e	15	5	exceptional	exceptional	JJ
cord-328189-jpkxjn6e	15	6	evolutionary	evolutionary	JJ
cord-328189-jpkxjn6e	15	7	exploration	exploration	NN
cord-328189-jpkxjn6e	15	8	exerted	exert	VBN
cord-328189-jpkxjn6e	15	9	by	by	IN
cord-328189-jpkxjn6e	15	10	coronaviruses	coronaviruse	NNS
cord-328189-jpkxjn6e	15	11	toward	toward	IN
cord-328189-jpkxjn6e	15	12	host	host	NN
cord-328189-jpkxjn6e	15	13	recognition	recognition	NN
cord-328189-jpkxjn6e	15	14	.	.	.
cord-328189-jpkxjn6e	16	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	16	2	postulate	postulate	VBP
cord-328189-jpkxjn6e	16	3	that	that	IN
cord-328189-jpkxjn6e	16	4	the	the	DT
cord-328189-jpkxjn6e	16	5	versatility	versatility	NN
cord-328189-jpkxjn6e	16	6	of	of	IN
cord-328189-jpkxjn6e	16	7	cell	cell	NN
cord-328189-jpkxjn6e	16	8	receptor	receptor	NN
cord-328189-jpkxjn6e	16	9	binding	bind	VBG
cord-328189-jpkxjn6e	16	10	strategies	strategy	NNS
cord-328189-jpkxjn6e	16	11	has	have	VBZ
cord-328189-jpkxjn6e	16	12	immediate	immediate	JJ
cord-328189-jpkxjn6e	16	13	implications	implication	NNS
cord-328189-jpkxjn6e	16	14	on	on	IN
cord-328189-jpkxjn6e	16	15	therapeutic	therapeutic	JJ
cord-328189-jpkxjn6e	16	16	strategies	strategy	NNS
cord-328189-jpkxjn6e	16	17	.	.	.
cord-328189-jpkxjn6e	17	1	One	one	CD
cord-328189-jpkxjn6e	17	2	Sentence	sentence	NN
cord-328189-jpkxjn6e	17	3	Summary	Summary	NNP
cord-328189-jpkxjn6e	17	4	Molecular	Molecular	NNP
cord-328189-jpkxjn6e	17	5	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	17	6	simulations	simulation	NNS
cord-328189-jpkxjn6e	17	7	reveal	reveal	VBP
cord-328189-jpkxjn6e	17	8	a	a	DT
cord-328189-jpkxjn6e	17	9	temporal	temporal	JJ
cord-328189-jpkxjn6e	17	10	dimension	dimension	NN
cord-328189-jpkxjn6e	17	11	of	of	IN
cord-328189-jpkxjn6e	17	12	coronaviruses	coronaviruse	NNS
cord-328189-jpkxjn6e	17	13	interactions	interaction	NNS
cord-328189-jpkxjn6e	17	14	with	with	IN
cord-328189-jpkxjn6e	17	15	the	the	DT
cord-328189-jpkxjn6e	17	16	host	host	NN
cord-328189-jpkxjn6e	17	17	receptor	receptor	NN
cord-328189-jpkxjn6e	17	18	.	.	.
cord-328189-jpkxjn6e	18	1	To	to	TO
cord-328189-jpkxjn6e	18	2	gain	gain	VB
cord-328189-jpkxjn6e	18	3	access	access	NN
cord-328189-jpkxjn6e	18	4	to	to	IN
cord-328189-jpkxjn6e	18	5	host	host	NN
cord-328189-jpkxjn6e	18	6	cells	cell	NNS
cord-328189-jpkxjn6e	18	7	,	,	,
cord-328189-jpkxjn6e	18	8	coronaviruses	coronaviruse	NNS
cord-328189-jpkxjn6e	18	9	rely	rely	VBP
cord-328189-jpkxjn6e	18	10	on	on	IN
cord-328189-jpkxjn6e	18	11	spike	spike	NN
cord-328189-jpkxjn6e	18	12	proteins	protein	NNS
cord-328189-jpkxjn6e	18	13	,	,	,
cord-328189-jpkxjn6e	18	14	which	which	WDT
cord-328189-jpkxjn6e	18	15	are	be	VBP
cord-328189-jpkxjn6e	18	16	membrane	membrane	NN
cord-328189-jpkxjn6e	18	17	-	-	HYPH
cord-328189-jpkxjn6e	18	18	anchored	anchor	VBN
cord-328189-jpkxjn6e	18	19	trimers	trimer	NNS
cord-328189-jpkxjn6e	18	20	containing	contain	VBG
cord-328189-jpkxjn6e	18	21	a	a	DT
cord-328189-jpkxjn6e	18	22	receptor	receptor	NN
cord-328189-jpkxjn6e	18	23	-	-	HYPH
cord-328189-jpkxjn6e	18	24	binding	bind	VBG
cord-328189-jpkxjn6e	18	25	S1	s1	NN
cord-328189-jpkxjn6e	18	26	segment	segment	NN
cord-328189-jpkxjn6e	18	27	and	and	CC
cord-328189-jpkxjn6e	18	28	a	a	DT
cord-328189-jpkxjn6e	18	29	membrane	membrane	NN
cord-328189-jpkxjn6e	18	30	-	-	HYPH
cord-328189-jpkxjn6e	18	31	fusion	fusion	NN
cord-328189-jpkxjn6e	18	32	S2	s2	NN
cord-328189-jpkxjn6e	18	33	segment	segment	NN
cord-328189-jpkxjn6e	18	34	(	(	-LRB-
cord-328189-jpkxjn6e	18	35	6	6	CD
cord-328189-jpkxjn6e	18	36	)	)	-RRB-
cord-328189-jpkxjn6e	18	37	.	.	.
cord-328189-jpkxjn6e	19	1	The	the	DT
cord-328189-jpkxjn6e	19	2	S1	s1	NN
cord-328189-jpkxjn6e	19	3	segment	segment	NN
cord-328189-jpkxjn6e	19	4	contains	contain	VBZ
cord-328189-jpkxjn6e	19	5	a	a	DT
cord-328189-jpkxjn6e	19	6	receptor	receptor	NN
cord-328189-jpkxjn6e	19	7	binding	bind	VBG
cord-328189-jpkxjn6e	19	8	domain	domain	NN
cord-328189-jpkxjn6e	19	9	(	(	-LRB-
cord-328189-jpkxjn6e	19	10	RBD	RBD	NNP
cord-328189-jpkxjn6e	19	11	)	)	-RRB-
cord-328189-jpkxjn6e	19	12	that	that	WDT
cord-328189-jpkxjn6e	19	13	recognizes	recognize	VBZ
cord-328189-jpkxjn6e	19	14	and	and	CC
cord-328189-jpkxjn6e	19	15	binds	bind	VBZ
cord-328189-jpkxjn6e	19	16	to	to	IN
cord-328189-jpkxjn6e	19	17	a	a	DT
cord-328189-jpkxjn6e	19	18	host	host	NN
cord-328189-jpkxjn6e	19	19	cell	cell	NN
cord-328189-jpkxjn6e	19	20	receptor	receptor	NN
cord-328189-jpkxjn6e	19	21	.	.	.
cord-328189-jpkxjn6e	20	1	The	the	DT
cord-328189-jpkxjn6e	20	2	angiotensin	angiotensin	NN
cord-328189-jpkxjn6e	20	3	-	-	HYPH
cord-328189-jpkxjn6e	20	4	converting	convert	VBG
cord-328189-jpkxjn6e	20	5	enzyme	enzyme	NN
cord-328189-jpkxjn6e	20	6	2	2	CD
cord-328189-jpkxjn6e	20	7	(	(	-LRB-
cord-328189-jpkxjn6e	20	8	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	20	9	)	)	-RRB-
cord-328189-jpkxjn6e	20	10	was	be	VBD
cord-328189-jpkxjn6e	20	11	identified	identify	VBN
cord-328189-jpkxjn6e	20	12	as	as	IN
cord-328189-jpkxjn6e	20	13	the	the	DT
cord-328189-jpkxjn6e	20	14	critical	critical	JJ
cord-328189-jpkxjn6e	20	15	receptor	receptor	NN
cord-328189-jpkxjn6e	20	16	for	for	IN
cord-328189-jpkxjn6e	20	17	mediating	mediate	VBG
cord-328189-jpkxjn6e	20	18	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	20	19	entry	entry	NN
cord-328189-jpkxjn6e	20	20	into	into	IN
cord-328189-jpkxjn6e	20	21	host	host	NN
cord-328189-jpkxjn6e	20	22	cells	cell	NNS
cord-328189-jpkxjn6e	20	23	(	(	-LRB-
cord-328189-jpkxjn6e	20	24	7	7	CD
cord-328189-jpkxjn6e	20	25	,	,	,
cord-328189-jpkxjn6e	20	26	8)	8)	NN
cord-328189-jpkxjn6e	20	27	.	.	.
cord-328189-jpkxjn6e	21	1	Binding	bind	VBG
cord-328189-jpkxjn6e	21	2	of	of	IN
cord-328189-jpkxjn6e	21	3	the	the	DT
cord-328189-jpkxjn6e	21	4	spike	spike	NN
cord-328189-jpkxjn6e	21	5	protein	protein	NN
cord-328189-jpkxjn6e	21	6	to	to	IN
cord-328189-jpkxjn6e	21	7	the	the	DT
cord-328189-jpkxjn6e	21	8	receptor	receptor	NN
cord-328189-jpkxjn6e	21	9	is	be	VBZ
cord-328189-jpkxjn6e	21	10	a	a	DT
cord-328189-jpkxjn6e	21	11	critical	critical	JJ
cord-328189-jpkxjn6e	21	12	phase	phase	NN
cord-328189-jpkxjn6e	21	13	where	where	WRB
cord-328189-jpkxjn6e	21	14	the	the	DT
cord-328189-jpkxjn6e	21	15	levels	level	NNS
cord-328189-jpkxjn6e	21	16	of	of	IN
cord-328189-jpkxjn6e	21	17	the	the	DT
cord-328189-jpkxjn6e	21	18	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	21	19	expressed	express	VBD
cord-328189-jpkxjn6e	21	20	on	on	IN
cord-328189-jpkxjn6e	21	21	the	the	DT
cord-328189-jpkxjn6e	21	22	cell	cell	NN
cord-328189-jpkxjn6e	21	23	membrane	membrane	NN
cord-328189-jpkxjn6e	21	24	correlates	correlate	VBZ
cord-328189-jpkxjn6e	21	25	with	with	IN
cord-328189-jpkxjn6e	21	26	viral	viral	JJ
cord-328189-jpkxjn6e	21	27	infectivity	infectivity	NN
cord-328189-jpkxjn6e	21	28	,	,	,
cord-328189-jpkxjn6e	21	29	and	and	CC
cord-328189-jpkxjn6e	21	30	govern	govern	VB
cord-328189-jpkxjn6e	21	31	clinical	clinical	JJ
cord-328189-jpkxjn6e	21	32	outcomes	outcome	NNS
cord-328189-jpkxjn6e	21	33	(	(	-LRB-
cord-328189-jpkxjn6e	21	34	9	9	CD
cord-328189-jpkxjn6e	21	35	)	)	-RRB-
cord-328189-jpkxjn6e	21	36	.	.	.
cord-328189-jpkxjn6e	22	1	Consistent	consistent	JJ
cord-328189-jpkxjn6e	22	2	with	with	IN
cord-328189-jpkxjn6e	22	3	the	the	DT
cord-328189-jpkxjn6e	22	4	clinical	clinical	JJ
cord-328189-jpkxjn6e	22	5	pulmonary	pulmonary	JJ
cord-328189-jpkxjn6e	22	6	manifestation	manifestation	NN
cord-328189-jpkxjn6e	22	7	,	,	,
cord-328189-jpkxjn6e	22	8	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	22	9	is	be	VBZ
cord-328189-jpkxjn6e	22	10	widely	widely	RB
cord-328189-jpkxjn6e	22	11	expressed	express	VBN
cord-328189-jpkxjn6e	22	12	in	in	IN
cord-328189-jpkxjn6e	22	13	almost	almost	RB
cord-328189-jpkxjn6e	22	14	all	all	DT
cord-328189-jpkxjn6e	22	15	tissues	tissue	NNS
cord-328189-jpkxjn6e	22	16	,	,	,
cord-328189-jpkxjn6e	22	17	with	with	IN
cord-328189-jpkxjn6e	22	18	the	the	DT
cord-328189-jpkxjn6e	22	19	highest	high	JJS
cord-328189-jpkxjn6e	22	20	expression	expression	NN
cord-328189-jpkxjn6e	22	21	levels	level	NNS
cord-328189-jpkxjn6e	22	22	in	in	IN
cord-328189-jpkxjn6e	22	23	the	the	DT
cord-328189-jpkxjn6e	22	24	epithelium	epithelium	NN
cord-328189-jpkxjn6e	22	25	of	of	IN
cord-328189-jpkxjn6e	22	26	the	the	DT
cord-328189-jpkxjn6e	22	27	lung	lung	NN
cord-328189-jpkxjn6e	22	28	(	(	-LRB-
cord-328189-jpkxjn6e	22	29	10	10	CD
cord-328189-jpkxjn6e	22	30	)	)	-RRB-
cord-328189-jpkxjn6e	22	31	.	.	.
cord-328189-jpkxjn6e	23	1	Similar	similar	JJ
cord-328189-jpkxjn6e	23	2	to	to	IN
cord-328189-jpkxjn6e	23	3	the	the	DT
cord-328189-jpkxjn6e	23	4	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	23	5	virus	virus	NN
cord-328189-jpkxjn6e	23	6	,	,	,
cord-328189-jpkxjn6e	23	7	the	the	DT
cord-328189-jpkxjn6e	23	8	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	23	9	virus	virus	NN
cord-328189-jpkxjn6e	23	10	enters	enter	VBZ
cord-328189-jpkxjn6e	23	11	the	the	DT
cord-328189-jpkxjn6e	23	12	host	host	NN
cord-328189-jpkxjn6e	23	13	cell	cell	NN
cord-328189-jpkxjn6e	23	14	by	by	IN
cord-328189-jpkxjn6e	23	15	RBD	RBD	NNP
cord-328189-jpkxjn6e	23	16	binding	bind	VBG
cord-328189-jpkxjn6e	23	17	to	to	IN
cord-328189-jpkxjn6e	23	18	the	the	DT
cord-328189-jpkxjn6e	23	19	host	host	NN
cord-328189-jpkxjn6e	23	20	cell	cell	NN
cord-328189-jpkxjn6e	23	21	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	23	22	receptor	receptor	NN
cord-328189-jpkxjn6e	23	23	(	(	-LRB-
cord-328189-jpkxjn6e	23	24	7	7	CD
cord-328189-jpkxjn6e	23	25	,	,	,
cord-328189-jpkxjn6e	23	26	11	11	CD
cord-328189-jpkxjn6e	23	27	,	,	,
cord-328189-jpkxjn6e	23	28	12	12	CD
cord-328189-jpkxjn6e	23	29	)	)	-RRB-
cord-328189-jpkxjn6e	23	30	.	.	.
cord-328189-jpkxjn6e	24	1	Host	host	NN
cord-328189-jpkxjn6e	24	2	receptor	receptor	NN
cord-328189-jpkxjn6e	24	3	recognition	recognition	NN
cord-328189-jpkxjn6e	24	4	for	for	IN
cord-328189-jpkxjn6e	24	5	cell	cell	NN
cord-328189-jpkxjn6e	24	6	entry	entry	NN
cord-328189-jpkxjn6e	24	7	is	be	VBZ
cord-328189-jpkxjn6e	24	8	,	,	,
cord-328189-jpkxjn6e	24	9	however	however	RB
cord-328189-jpkxjn6e	24	10	,	,	,
cord-328189-jpkxjn6e	24	11	not	not	RB
cord-328189-jpkxjn6e	24	12	specified	specify	VBN
cord-328189-jpkxjn6e	24	13	by	by	IN
cord-328189-jpkxjn6e	24	14	the	the	DT
cord-328189-jpkxjn6e	24	15	CoV	cov	NN
cord-328189-jpkxjn6e	24	16	genus	genus	NN
cord-328189-jpkxjn6e	24	17	classification	classification	NN
cord-328189-jpkxjn6e	24	18	.	.	.
cord-328189-jpkxjn6e	25	1	MERS	MERS	NNP
cord-328189-jpkxjn6e	25	2	-	-	HYPH
cord-328189-jpkxjn6e	25	3	CoV	CoV	NNP
cord-328189-jpkxjn6e	25	4	is	be	VBZ
cord-328189-jpkxjn6e	25	5	a	a	DT
cord-328189-jpkxjn6e	25	6	member	member	NN
cord-328189-jpkxjn6e	25	7	of	of	IN
cord-328189-jpkxjn6e	25	8	the	the	DT
cord-328189-jpkxjn6e	25	9	BCoV	BCoV	NNP
cord-328189-jpkxjn6e	25	10	genus	genus	NN
cord-328189-jpkxjn6e	25	11	but	but	CC
cord-328189-jpkxjn6e	25	12	does	do	VBZ
cord-328189-jpkxjn6e	25	13	not	not	RB
cord-328189-jpkxjn6e	25	14	recognize	recognize	VB
cord-328189-jpkxjn6e	25	15	the	the	DT
cord-328189-jpkxjn6e	25	16	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	25	17	receptor	receptor	NN
cord-328189-jpkxjn6e	25	18	.	.	.
cord-328189-jpkxjn6e	26	1	In	in	IN
cord-328189-jpkxjn6e	26	2	contrast	contrast	NN
cord-328189-jpkxjn6e	26	3	,	,	,
cord-328189-jpkxjn6e	26	4	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	26	5	-	-	HYPH
cord-328189-jpkxjn6e	26	6	NL63	NL63	NNP
cord-328189-jpkxjn6e	26	7	is	be	VBZ
cord-328189-jpkxjn6e	26	8	a	a	DT
cord-328189-jpkxjn6e	26	9	member	member	NN
cord-328189-jpkxjn6e	26	10	of	of	IN
cord-328189-jpkxjn6e	26	11	the	the	DT
cord-328189-jpkxjn6e	26	12	ACoV	ACoV	NNP
cord-328189-jpkxjn6e	26	13	genus	genus	NN
cord-328189-jpkxjn6e	26	14	and	and	CC
cord-328189-jpkxjn6e	26	15	does	do	VBZ
cord-328189-jpkxjn6e	26	16	recognize	recognize	VB
cord-328189-jpkxjn6e	26	17	the	the	DT
cord-328189-jpkxjn6e	26	18	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	26	19	receptor	receptor	NN
cord-328189-jpkxjn6e	26	20	(	(	-LRB-
cord-328189-jpkxjn6e	26	21	13	13	CD
cord-328189-jpkxjn6e	26	22	)	)	-RRB-
cord-328189-jpkxjn6e	26	23	.	.	.
cord-328189-jpkxjn6e	27	1	Herein	herein	RB
cord-328189-jpkxjn6e	27	2	,	,	,
cord-328189-jpkxjn6e	27	3	we	-PRON-	PRP
cord-328189-jpkxjn6e	27	4	analyze	analyze	VBP
cord-328189-jpkxjn6e	27	5	the	the	DT
cord-328189-jpkxjn6e	27	6	binding	binding	NN
cord-328189-jpkxjn6e	27	7	of	of	IN
cord-328189-jpkxjn6e	27	8	several	several	JJ
cord-328189-jpkxjn6e	27	9	CoV	cov	NN
cord-328189-jpkxjn6e	27	10	RBDs	rbds	NN
cord-328189-jpkxjn6e	27	11	to	to	IN
cord-328189-jpkxjn6e	27	12	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	27	13	with	with	IN
cord-328189-jpkxjn6e	27	14	molecular	molecular	JJ
cord-328189-jpkxjn6e	27	15	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	27	16	(	(	-LRB-
cord-328189-jpkxjn6e	27	17	MD	MD	NNP
cord-328189-jpkxjn6e	27	18	)	)	-RRB-
cord-328189-jpkxjn6e	27	19	simulations	simulation	NNS
cord-328189-jpkxjn6e	27	20	and	and	CC
cord-328189-jpkxjn6e	27	21	compare	compare	VB
cord-328189-jpkxjn6e	27	22	the	the	DT
cord-328189-jpkxjn6e	27	23	stability	stability	NN
cord-328189-jpkxjn6e	27	24	,	,	,
cord-328189-jpkxjn6e	27	25	relative	relative	JJ
cord-328189-jpkxjn6e	27	26	interaction	interaction	NN
cord-328189-jpkxjn6e	27	27	strength	strength	NN
cord-328189-jpkxjn6e	27	28	,	,	,
cord-328189-jpkxjn6e	27	29	and	and	CC
cord-328189-jpkxjn6e	27	30	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	27	31	of	of	IN
cord-328189-jpkxjn6e	27	32	the	the	DT
cord-328189-jpkxjn6e	27	33	interaction	interaction	NN
cord-328189-jpkxjn6e	27	34	between	between	IN
cord-328189-jpkxjn6e	27	35	the	the	DT
cord-328189-jpkxjn6e	27	36	viral	viral	JJ
cord-328189-jpkxjn6e	27	37	spike	spike	NN
cord-328189-jpkxjn6e	27	38	protein	protein	NN
cord-328189-jpkxjn6e	27	39	and	and	CC
cord-328189-jpkxjn6e	27	40	the	the	DT
cord-328189-jpkxjn6e	27	41	human	human	JJ
cord-328189-jpkxjn6e	27	42	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	27	43	receptor	receptor	NN
cord-328189-jpkxjn6e	27	44	.	.	.
cord-328189-jpkxjn6e	28	1	The	the	DT
cord-328189-jpkxjn6e	28	2	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	28	3	RBD	RBD	NNP
cord-328189-jpkxjn6e	28	4	(	(	-LRB-
cord-328189-jpkxjn6e	28	5	residues	residue	NNS
cord-328189-jpkxjn6e	28	6	319	319	CD
cord-328189-jpkxjn6e	28	7	-	-	SYM
cord-328189-jpkxjn6e	28	8	529	529	CD
cord-328189-jpkxjn6e	28	9	)	)	-RRB-
cord-328189-jpkxjn6e	28	10	shares	share	VBZ
cord-328189-jpkxjn6e	28	11	a	a	DT
cord-328189-jpkxjn6e	28	12	72.8	72.8	CD
cord-328189-jpkxjn6e	28	13	%	%	NN
cord-328189-jpkxjn6e	28	14	sequence	sequence	NN
cord-328189-jpkxjn6e	28	15	identity	identity	NN
cord-328189-jpkxjn6e	28	16	and	and	CC
cord-328189-jpkxjn6e	28	17	high	high	JJ
cord-328189-jpkxjn6e	28	18	structural	structural	JJ
cord-328189-jpkxjn6e	28	19	similarity	similarity	NN
cord-328189-jpkxjn6e	28	20	with	with	IN
cord-328189-jpkxjn6e	28	21	the	the	DT
cord-328189-jpkxjn6e	28	22	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	28	23	RBD	RBD	NNP
cord-328189-jpkxjn6e	28	24	(	(	-LRB-
cord-328189-jpkxjn6e	28	25	Table	table	NN
cord-328189-jpkxjn6e	28	26	1	1	CD
cord-328189-jpkxjn6e	28	27	)	)	-RRB-
cord-328189-jpkxjn6e	28	28	.	.	.
cord-328189-jpkxjn6e	29	1	In	in	IN
cord-328189-jpkxjn6e	29	2	contrast	contrast	NN
cord-328189-jpkxjn6e	29	3	,	,	,
cord-328189-jpkxjn6e	29	4	the	the	DT
cord-328189-jpkxjn6e	29	5	RBD	RBD	NNP
cord-328189-jpkxjn6e	29	6	of	of	IN
cord-328189-jpkxjn6e	29	7	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	29	8	-	-	:
cord-328189-jpkxjn6e	29	9	NL63	NL63	NNP
cord-328189-jpkxjn6e	29	10	is	be	VBZ
cord-328189-jpkxjn6e	29	11	only	only	RB
cord-328189-jpkxjn6e	29	12	17.1	17.1	CD
cord-328189-jpkxjn6e	29	13	%	%	NN
cord-328189-jpkxjn6e	29	14	identical	identical	JJ
cord-328189-jpkxjn6e	29	15	to	to	IN
cord-328189-jpkxjn6e	29	16	that	that	DT
cord-328189-jpkxjn6e	29	17	of	of	IN
cord-328189-jpkxjn6e	29	18	COVID-19	covid-19	VB
cord-328189-jpkxjn6e	29	19	and	and	CC
cord-328189-jpkxjn6e	29	20	there	there	EX
cord-328189-jpkxjn6e	29	21	are	be	VBP
cord-328189-jpkxjn6e	29	22	no	no	DT
cord-328189-jpkxjn6e	29	23	significant	significant	JJ
cord-328189-jpkxjn6e	29	24	structural	structural	JJ
cord-328189-jpkxjn6e	29	25	similarities	similarity	NNS
cord-328189-jpkxjn6e	29	26	between	between	IN
cord-328189-jpkxjn6e	29	27	them	-PRON-	PRP
cord-328189-jpkxjn6e	29	28	(	(	-LRB-
cord-328189-jpkxjn6e	29	29	Fig	Fig	NNP
cord-328189-jpkxjn6e	29	30	.	.	.
cord-328189-jpkxjn6e	29	31	S1	S1	NNP
cord-328189-jpkxjn6e	29	32	)	)	-RRB-
cord-328189-jpkxjn6e	29	33	.	.	.
cord-328189-jpkxjn6e	30	1	Remarkably	remarkably	RB
cord-328189-jpkxjn6e	30	2	,	,	,
cord-328189-jpkxjn6e	30	3	the	the	DT
cord-328189-jpkxjn6e	30	4	RBD	RBD	NNP
cord-328189-jpkxjn6e	30	5	of	of	IN
cord-328189-jpkxjn6e	30	6	MERS	MERS	NNP
cord-328189-jpkxjn6e	30	7	-	-	HYPH
cord-328189-jpkxjn6e	30	8	CoV	CoV	NNP
cord-328189-jpkxjn6e	30	9	,	,	,
cord-328189-jpkxjn6e	30	10	which	which	WDT
cord-328189-jpkxjn6e	30	11	is	be	VBZ
cord-328189-jpkxjn6e	30	12	structurally	structurally	RB
cord-328189-jpkxjn6e	30	13	similar	similar	JJ
cord-328189-jpkxjn6e	30	14	to	to	IN
cord-328189-jpkxjn6e	30	15	that	that	DT
cord-328189-jpkxjn6e	30	16	of	of	IN
cord-328189-jpkxjn6e	30	17	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	30	18	(	(	-LRB-
cord-328189-jpkxjn6e	30	19	20.1	20.1	CD
cord-328189-jpkxjn6e	30	20	%	%	NN
cord-328189-jpkxjn6e	30	21	sequence	sequence	NN
cord-328189-jpkxjn6e	30	22	identity	identity	NN
cord-328189-jpkxjn6e	30	23	,	,	,
cord-328189-jpkxjn6e	30	24	65	65	CD
cord-328189-jpkxjn6e	30	25	%	%	NN
cord-328189-jpkxjn6e	30	26	structure	structure	NN
cord-328189-jpkxjn6e	30	27	similarity	similarity	NN
cord-328189-jpkxjn6e	30	28	)	)	-RRB-
cord-328189-jpkxjn6e	30	29	recognizes	recognize	VBZ
cord-328189-jpkxjn6e	30	30	a	a	DT
cord-328189-jpkxjn6e	30	31	different	different	JJ
cord-328189-jpkxjn6e	30	32	host	host	NN
cord-328189-jpkxjn6e	30	33	receptor	receptor	NN
cord-328189-jpkxjn6e	30	34	(	(	-LRB-
cord-328189-jpkxjn6e	30	35	DPP4	DPP4	NNP
cord-328189-jpkxjn6e	30	36	)	)	-RRB-
cord-328189-jpkxjn6e	30	37	for	for	IN
cord-328189-jpkxjn6e	30	38	its	-PRON-	PRP$
cord-328189-jpkxjn6e	30	39	cell	cell	NN
cord-328189-jpkxjn6e	30	40	entry	entry	NN
cord-328189-jpkxjn6e	30	41	and	and	CC
cord-328189-jpkxjn6e	30	42	does	do	VBZ
cord-328189-jpkxjn6e	30	43	not	not	RB
cord-328189-jpkxjn6e	30	44	bind	bind	VB
cord-328189-jpkxjn6e	30	45	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	30	46	(	(	-LRB-
cord-328189-jpkxjn6e	30	47	14	14	CD
cord-328189-jpkxjn6e	30	48	)	)	-RRB-
cord-328189-jpkxjn6e	30	49	.	.	.
cord-328189-jpkxjn6e	31	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	31	2	ran	run	VBD
cord-328189-jpkxjn6e	31	3	100ns	100ns	JJ
cord-328189-jpkxjn6e	31	4	molecular	molecular	JJ
cord-328189-jpkxjn6e	31	5	dynamic	dynamic	NNP
cord-328189-jpkxjn6e	31	6	(	(	-LRB-
cord-328189-jpkxjn6e	31	7	MD	MD	NNP
cord-328189-jpkxjn6e	31	8	)	)	-RRB-
cord-328189-jpkxjn6e	31	9	simulations	simulation	NNS
cord-328189-jpkxjn6e	31	10	of	of	IN
cord-328189-jpkxjn6e	31	11	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	31	12	in	in	IN
cord-328189-jpkxjn6e	31	13	complex	complex	NN
cord-328189-jpkxjn6e	31	14	with	with	IN
cord-328189-jpkxjn6e	31	15	the	the	DT
cord-328189-jpkxjn6e	31	16	RBDs	rbds	NN
cord-328189-jpkxjn6e	31	17	of	of	IN
cord-328189-jpkxjn6e	31	18	the	the	DT
cord-328189-jpkxjn6e	31	19	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	31	20	,	,	,
cord-328189-jpkxjn6e	31	21	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	31	22	,	,	,
cord-328189-jpkxjn6e	31	23	and	and	CC
cord-328189-jpkxjn6e	31	24	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	31	25	-	-	HYPH
cord-328189-jpkxjn6e	31	26	NL63	NL63	NNP
cord-328189-jpkxjn6e	31	27	viruses	virus	NNS
cord-328189-jpkxjn6e	31	28	to	to	TO
cord-328189-jpkxjn6e	31	29	quantify	quantify	VB
cord-328189-jpkxjn6e	31	30	the	the	DT
cord-328189-jpkxjn6e	31	31	energetics	energetic	NNS
cord-328189-jpkxjn6e	31	32	and	and	CC
cord-328189-jpkxjn6e	31	33	the	the	DT
cord-328189-jpkxjn6e	31	34	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	31	35	of	of	IN
cord-328189-jpkxjn6e	31	36	the	the	DT
cord-328189-jpkxjn6e	31	37	different	different	JJ
cord-328189-jpkxjn6e	31	38	RBD	RBD	NNP
cord-328189-jpkxjn6e	31	39	-	-	HYPH
cord-328189-jpkxjn6e	31	40	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	31	41	interactions	interaction	NNS
cord-328189-jpkxjn6e	31	42	.	.	.
cord-328189-jpkxjn6e	32	1	The	the	DT
cord-328189-jpkxjn6e	32	2	simulation	simulation	NN
cord-328189-jpkxjn6e	32	3	trajectory	trajectory	NN
cord-328189-jpkxjn6e	32	4	snapshots	snapshot	NNS
cord-328189-jpkxjn6e	32	5	at	at	IN
cord-328189-jpkxjn6e	32	6	10	10	CD
cord-328189-jpkxjn6e	32	7	ps	ps	NNP
cord-328189-jpkxjn6e	32	8	intervals	interval	NNS
cord-328189-jpkxjn6e	32	9	(	(	-LRB-
cord-328189-jpkxjn6e	32	10	10,000	10,000	CD
cord-328189-jpkxjn6e	32	11	frames	frame	NNS
cord-328189-jpkxjn6e	32	12	)	)	-RRB-
cord-328189-jpkxjn6e	32	13	were	be	VBD
cord-328189-jpkxjn6e	32	14	analyzed	analyze	VBN
cord-328189-jpkxjn6e	32	15	by	by	IN
cord-328189-jpkxjn6e	32	16	a	a	DT
cord-328189-jpkxjn6e	32	17	statistical	statistical	JJ
cord-328189-jpkxjn6e	32	18	potential	potential	NN
cord-328189-jpkxjn6e	32	19	to	to	TO
cord-328189-jpkxjn6e	32	20	assess	assess	VB
cord-328189-jpkxjn6e	32	21	the	the	DT
cord-328189-jpkxjn6e	32	22	probability	probability	NN
cord-328189-jpkxjn6e	32	23	of	of	IN
cord-328189-jpkxjn6e	32	24	the	the	DT
cord-328189-jpkxjn6e	32	25	RBD	RBD	NNP
cord-328189-jpkxjn6e	32	26	-	-	HYPH
cord-328189-jpkxjn6e	32	27	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	32	28	interaction	interaction	NN
cord-328189-jpkxjn6e	32	29	(	(	-LRB-
cord-328189-jpkxjn6e	32	30	SOAP	soap	NN
cord-328189-jpkxjn6e	32	31	score	score	NN
cord-328189-jpkxjn6e	32	32	,	,	,
cord-328189-jpkxjn6e	32	33	(	(	-LRB-
cord-328189-jpkxjn6e	32	34	16	16	CD
cord-328189-jpkxjn6e	32	35	)	)	-RRB-
cord-328189-jpkxjn6e	32	36	)	)	-RRB-
cord-328189-jpkxjn6e	32	37	,	,	,
cord-328189-jpkxjn6e	32	38	with	with	IN
cord-328189-jpkxjn6e	32	39	lower	low	JJR
cord-328189-jpkxjn6e	32	40	values	value	NNS
cord-328189-jpkxjn6e	32	41	corresponding	correspond	VBG
cord-328189-jpkxjn6e	32	42	to	to	IN
cord-328189-jpkxjn6e	32	43	higher	high	JJR
cord-328189-jpkxjn6e	32	44	probabilities	probability	NNS
cord-328189-jpkxjn6e	32	45	and	and	CC
cord-328189-jpkxjn6e	32	46	thus	thus	RB
cord-328189-jpkxjn6e	32	47	higher	high	JJR
cord-328189-jpkxjn6e	32	48	affinities	affinity	NNS
cord-328189-jpkxjn6e	32	49	.	.	.
cord-328189-jpkxjn6e	33	1	The	the	DT
cord-328189-jpkxjn6e	33	2	interaction	interaction	NN
cord-328189-jpkxjn6e	33	3	scores	score	VBZ
cord-328189-jpkxjn6e	33	4	for	for	IN
cord-328189-jpkxjn6e	33	5	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	33	6	RBD	RBD	NNP
cord-328189-jpkxjn6e	33	7	-	-	HYPH
cord-328189-jpkxjn6e	33	8	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	33	9	were	be	VBD
cord-328189-jpkxjn6e	33	10	comparable	comparable	JJ
cord-328189-jpkxjn6e	33	11	to	to	IN
cord-328189-jpkxjn6e	33	12	those	those	DT
cord-328189-jpkxjn6e	33	13	of	of	IN
cord-328189-jpkxjn6e	33	14	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	33	15	,	,	,
cord-328189-jpkxjn6e	33	16	median	median	NN
cord-328189-jpkxjn6e	33	17	of	of	IN
cord-328189-jpkxjn6e	33	18	-1865.9	-1865.9	.
cord-328189-jpkxjn6e	34	1	and	and	CC
cord-328189-jpkxjn6e	34	2	-1929.5	-1929.5	:
cord-328189-jpkxjn6e	34	3	,	,	,
cord-328189-jpkxjn6e	34	4	respectively	respectively	RB
cord-328189-jpkxjn6e	34	5	(	(	-LRB-
cord-328189-jpkxjn6e	34	6	Fig	Fig	NNP
cord-328189-jpkxjn6e	34	7	.	.	.
cord-328189-jpkxjn6e	34	8	1A	1a	NN
cord-328189-jpkxjn6e	34	9	)	)	-RRB-
cord-328189-jpkxjn6e	34	10	.	.	.
cord-328189-jpkxjn6e	35	1	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	36	1	-NL63	-NL63	:
cord-328189-jpkxjn6e	36	2	has	have	VBZ
cord-328189-jpkxjn6e	36	3	RBD	RBD	NNP
cord-328189-jpkxjn6e	36	4	-	-	HYPH
cord-328189-jpkxjn6e	36	5	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	36	6	interaction	interaction	NN
cord-328189-jpkxjn6e	36	7	scores	score	NNS
cord-328189-jpkxjn6e	36	8	are	be	VBP
cord-328189-jpkxjn6e	36	9	higher	high	JJR
cord-328189-jpkxjn6e	36	10	than	than	IN
cord-328189-jpkxjn6e	36	11	both	both	DT
cord-328189-jpkxjn6e	36	12	of	of	IN
cord-328189-jpkxjn6e	36	13	the	the	DT
cord-328189-jpkxjn6e	36	14	SARS	SARS	NNP
cord-328189-jpkxjn6e	36	15	-	-	HYPH
cord-328189-jpkxjn6e	36	16	CoVs	CoVs	NNP
cord-328189-jpkxjn6e	36	17	(	(	-LRB-
cord-328189-jpkxjn6e	36	18	median	median	NN
cord-328189-jpkxjn6e	36	19	of	of	IN
cord-328189-jpkxjn6e	36	20	-941.6	-941.6	CD
cord-328189-jpkxjn6e	36	21	)	)	-RRB-
cord-328189-jpkxjn6e	36	22	.	.	.
cord-328189-jpkxjn6e	37	1	MERS	MERS	NNP
cord-328189-jpkxjn6e	37	2	,	,	,
cord-328189-jpkxjn6e	37	3	which	which	WDT
cord-328189-jpkxjn6e	37	4	is	be	VBZ
cord-328189-jpkxjn6e	37	5	structurally	structurally	RB
cord-328189-jpkxjn6e	37	6	similar	similar	JJ
cord-328189-jpkxjn6e	37	7	to	to	IN
cord-328189-jpkxjn6e	37	8	COVID-19	covid-19	VB
cord-328189-jpkxjn6e	37	9	(	(	-LRB-
cord-328189-jpkxjn6e	37	10	Table	table	NN
cord-328189-jpkxjn6e	37	11	1	1	CD
cord-328189-jpkxjn6e	37	12	)	)	-RRB-
cord-328189-jpkxjn6e	37	13	does	do	VBZ
cord-328189-jpkxjn6e	37	14	not	not	RB
cord-328189-jpkxjn6e	37	15	bind	bind	VB
cord-328189-jpkxjn6e	37	16	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	37	17	.	.	.
cord-328189-jpkxjn6e	38	1	MERS	MERS	NNP
cord-328189-jpkxjn6e	38	2	virus	virus	NN
cord-328189-jpkxjn6e	38	3	which	which	WDT
cord-328189-jpkxjn6e	38	4	binds	bind	VBZ
cord-328189-jpkxjn6e	38	5	dipeptidyl	dipeptidyl	JJ
cord-328189-jpkxjn6e	38	6	peptidase-4	peptidase-4	NNP
cord-328189-jpkxjn6e	38	7	(	(	-LRB-
cord-328189-jpkxjn6e	38	8	DPP4	DPP4	NNP
cord-328189-jpkxjn6e	38	9	,	,	,
cord-328189-jpkxjn6e	38	10	also	also	RB
cord-328189-jpkxjn6e	38	11	known	know	VBN
cord-328189-jpkxjn6e	38	12	as	as	IN
cord-328189-jpkxjn6e	38	13	CD26	CD26	NNP
cord-328189-jpkxjn6e	38	14	(	(	-LRB-
cord-328189-jpkxjn6e	38	15	14	14	CD
cord-328189-jpkxjn6e	38	16	)	)	-RRB-
cord-328189-jpkxjn6e	38	17	)	)	-RRB-
cord-328189-jpkxjn6e	38	18	,	,	,
cord-328189-jpkxjn6e	38	19	has	have	VBZ
cord-328189-jpkxjn6e	38	20	RBD	RBD	NNP
cord-328189-jpkxjn6e	38	21	-	-	HYPH
cord-328189-jpkxjn6e	38	22	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	38	23	interaction	interaction	NN
cord-328189-jpkxjn6e	38	24	scores	score	NNS
cord-328189-jpkxjn6e	38	25	that	that	WDT
cord-328189-jpkxjn6e	38	26	indicate	indicate	VBP
cord-328189-jpkxjn6e	38	27	extremely	extremely	RB
cord-328189-jpkxjn6e	38	28	weak	weak	JJ
cord-328189-jpkxjn6e	38	29	affinity	affinity	NN
cord-328189-jpkxjn6e	38	30	(	(	-LRB-
cord-328189-jpkxjn6e	38	31	median	median	NN
cord-328189-jpkxjn6e	38	32	of	of	IN
cord-328189-jpkxjn6e	38	33	-692.6	-692.6	CD
cord-328189-jpkxjn6e	38	34	)	)	-RRB-
cord-328189-jpkxjn6e	38	35	,	,	,
cord-328189-jpkxjn6e	38	36	as	as	IN
cord-328189-jpkxjn6e	38	37	expected	expect	VBN
cord-328189-jpkxjn6e	38	38	from	from	IN
cord-328189-jpkxjn6e	38	39	a	a	DT
cord-328189-jpkxjn6e	38	40	non	non	JJ
cord-328189-jpkxjn6e	38	41	-	-	JJ
cord-328189-jpkxjn6e	38	42	cognate	cognate	JJ
cord-328189-jpkxjn6e	38	43	receptor	receptor	NN
cord-328189-jpkxjn6e	38	44	interaction	interaction	NN
cord-328189-jpkxjn6e	38	45	.	.	.
cord-328189-jpkxjn6e	39	1	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	39	2	has	have	VBZ
cord-328189-jpkxjn6e	39	3	the	the	DT
cord-328189-jpkxjn6e	39	4	largest	large	JJS
cord-328189-jpkxjn6e	39	5	buried	bury	VBN
cord-328189-jpkxjn6e	39	6	surface	surface	NN
cord-328189-jpkxjn6e	39	7	area	area	NN
cord-328189-jpkxjn6e	39	8	at	at	IN
cord-328189-jpkxjn6e	39	9	the	the	DT
cord-328189-jpkxjn6e	39	10	interface	interface	NN
cord-328189-jpkxjn6e	39	11	(	(	-LRB-
cord-328189-jpkxjn6e	39	12	1204Å	1204å	CD
cord-328189-jpkxjn6e	39	13	2	2	CD
cord-328189-jpkxjn6e	39	14	)	)	-RRB-
cord-328189-jpkxjn6e	39	15	,	,	,
cord-328189-jpkxjn6e	39	16	followed	follow	VBN
cord-328189-jpkxjn6e	39	17	by	by	IN
cord-328189-jpkxjn6e	39	18	the	the	DT
cord-328189-jpkxjn6e	39	19	interface	interface	NN
cord-328189-jpkxjn6e	39	20	area	area	NN
cord-328189-jpkxjn6e	39	21	for	for	IN
cord-328189-jpkxjn6e	39	22	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	39	23	(	(	-LRB-
cord-328189-jpkxjn6e	39	24	998Å	998å	CD
cord-328189-jpkxjn6e	39	25	2	2	CD
cord-328189-jpkxjn6e	39	26	)	)	-RRB-
cord-328189-jpkxjn6e	40	1	and	and	CC
cord-328189-jpkxjn6e	40	2	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	40	3	-	-	HYPH
cord-328189-jpkxjn6e	40	4	NL63	NL63	NNP
cord-328189-jpkxjn6e	40	5	(	(	-LRB-
cord-328189-jpkxjn6e	40	6	973Å	973å	CD
cord-328189-jpkxjn6e	40	7	2	2	CD
cord-328189-jpkxjn6e	40	8	)	)	-RRB-
cord-328189-jpkxjn6e	40	9	.	.	.
cord-328189-jpkxjn6e	41	1	The	the	DT
cord-328189-jpkxjn6e	41	2	number	number	NN
cord-328189-jpkxjn6e	41	3	of	of	IN
cord-328189-jpkxjn6e	41	4	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	41	5	contacting	contact	VBG
cord-328189-jpkxjn6e	41	6	residues	residue	NNS
cord-328189-jpkxjn6e	41	7	maintains	maintain	VBZ
cord-328189-jpkxjn6e	41	8	the	the	DT
cord-328189-jpkxjn6e	41	9	same	same	JJ
cord-328189-jpkxjn6e	41	10	order	order	NN
cord-328189-jpkxjn6e	41	11	,	,	,
cord-328189-jpkxjn6e	41	12	with	with	IN
cord-328189-jpkxjn6e	41	13	30	30	CD
cord-328189-jpkxjn6e	41	14	,	,	,
cord-328189-jpkxjn6e	41	15	24	24	CD
cord-328189-jpkxjn6e	41	16	,	,	,
cord-328189-jpkxjn6e	41	17	and	and	CC
cord-328189-jpkxjn6e	41	18	23	23	CD
cord-328189-jpkxjn6e	41	19	for	for	IN
cord-328189-jpkxjn6e	41	20	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	41	21	,	,	,
cord-328189-jpkxjn6e	41	22	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	41	23	,	,	,
cord-328189-jpkxjn6e	41	24	and	and	CC
cord-328189-jpkxjn6e	41	25	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	41	26	-	-	HYPH
cord-328189-jpkxjn6e	41	27	NL63	NL63	NNP
cord-328189-jpkxjn6e	41	28	,	,	,
cord-328189-jpkxjn6e	41	29	respectively	respectively	RB
cord-328189-jpkxjn6e	41	30	(	(	-LRB-
cord-328189-jpkxjn6e	41	31	Fig	Fig	NNP
cord-328189-jpkxjn6e	41	32	.	.	.
cord-328189-jpkxjn6e	41	33	1C	1C	NNP
cord-328189-jpkxjn6e	41	34	)	)	-RRB-
cord-328189-jpkxjn6e	41	35	.	.	.
cord-328189-jpkxjn6e	42	1	The	the	DT
cord-328189-jpkxjn6e	42	2	three	three	CD
cord-328189-jpkxjn6e	42	3	RBDs	rbd	NNS
cord-328189-jpkxjn6e	42	4	exploit	exploit	VB
cord-328189-jpkxjn6e	42	5	specific	specific	JJ
cord-328189-jpkxjn6e	42	6	binding	bind	VBG
cord-328189-jpkxjn6e	42	7	sites	site	NNS
cord-328189-jpkxjn6e	42	8	on	on	IN
cord-328189-jpkxjn6e	42	9	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	42	10	based	base	VBN
cord-328189-jpkxjn6e	42	11	on	on	IN
cord-328189-jpkxjn6e	42	12	the	the	DT
cord-328189-jpkxjn6e	42	13	analysis	analysis	NN
cord-328189-jpkxjn6e	42	14	of	of	IN
cord-328189-jpkxjn6e	42	15	the	the	DT
cord-328189-jpkxjn6e	42	16	MD	MD	NNP
cord-328189-jpkxjn6e	42	17	trajectories	trajectory	NNS
cord-328189-jpkxjn6e	42	18	(	(	-LRB-
cord-328189-jpkxjn6e	42	19	Fig	Fig	NNP
cord-328189-jpkxjn6e	42	20	.	.	NNP
cord-328189-jpkxjn6e	42	21	1	1	CD
cord-328189-jpkxjn6e	42	22	,	,	,
cord-328189-jpkxjn6e	42	23	C	C	NNP
cord-328189-jpkxjn6e	42	24	and	and	CC
cord-328189-jpkxjn6e	42	25	D	D	NNP
cord-328189-jpkxjn6e	42	26	;	;	:
cord-328189-jpkxjn6e	42	27	Movie	Movie	NNP
cord-328189-jpkxjn6e	42	28	S1	S1	NNP
cord-328189-jpkxjn6e	42	29	)	)	-RRB-
cord-328189-jpkxjn6e	42	30	.	.	.
cord-328189-jpkxjn6e	43	1	There	there	EX
cord-328189-jpkxjn6e	43	2	is	be	VBZ
cord-328189-jpkxjn6e	43	3	a	a	DT
cord-328189-jpkxjn6e	43	4	significant	significant	JJ
cord-328189-jpkxjn6e	43	5	overlap	overlap	NN
cord-328189-jpkxjn6e	43	6	of	of	IN
cord-328189-jpkxjn6e	43	7	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	43	8	interacting	interact	VBG
cord-328189-jpkxjn6e	43	9	residues	residue	NNS
cord-328189-jpkxjn6e	43	10	between	between	IN
cord-328189-jpkxjn6e	43	11	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	43	12	and	and	CC
cord-328189-jpkxjn6e	43	13	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	43	14	(	(	-LRB-
cord-328189-jpkxjn6e	43	15	at	at	RB
cord-328189-jpkxjn6e	43	16	least	least	RBS
cord-328189-jpkxjn6e	43	17	73	73	CD
cord-328189-jpkxjn6e	43	18	%	%	NN
cord-328189-jpkxjn6e	43	19	)	)	-RRB-
cord-328189-jpkxjn6e	43	20	,	,	,
cord-328189-jpkxjn6e	43	21	while	while	IN
cord-328189-jpkxjn6e	43	22	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	43	23	-	-	HYPH
cord-328189-jpkxjn6e	43	24	NL63	NL63	NNP
cord-328189-jpkxjn6e	43	25	shares	share	NNS
cord-328189-jpkxjn6e	43	26	only	only	RB
cord-328189-jpkxjn6e	43	27	17	17	CD
cord-328189-jpkxjn6e	43	28	%	%	NN
cord-328189-jpkxjn6e	43	29	and	and	CC
cord-328189-jpkxjn6e	43	30	36	36	CD
cord-328189-jpkxjn6e	43	31	%	%	NN
cord-328189-jpkxjn6e	43	32	of	of	IN
cord-328189-jpkxjn6e	43	33	contacts	contact	NNS
cord-328189-jpkxjn6e	43	34	with	with	IN
cord-328189-jpkxjn6e	43	35	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	43	36	and	and	CC
cord-328189-jpkxjn6e	43	37	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	43	38	,	,	,
cord-328189-jpkxjn6e	43	39	respectively	respectively	RB
cord-328189-jpkxjn6e	43	40	.	.	.
cord-328189-jpkxjn6e	44	1	These	these	DT
cord-328189-jpkxjn6e	44	2	findings	finding	NNS
cord-328189-jpkxjn6e	44	3	suggest	suggest	VBP
cord-328189-jpkxjn6e	44	4	that	that	IN
cord-328189-jpkxjn6e	44	5	the	the	DT
cord-328189-jpkxjn6e	44	6	coronaviruses	coronaviruse	NNS
cord-328189-jpkxjn6e	44	7	exert	exert	VBP
cord-328189-jpkxjn6e	44	8	different	different	JJ
cord-328189-jpkxjn6e	44	9	interaction	interaction	NN
cord-328189-jpkxjn6e	44	10	strategies	strategy	NNS
cord-328189-jpkxjn6e	44	11	with	with	IN
cord-328189-jpkxjn6e	44	12	their	-PRON-	PRP$
cord-328189-jpkxjn6e	44	13	cognate	cognate	JJ
cord-328189-jpkxjn6e	44	14	receptors	receptor	NNS
cord-328189-jpkxjn6e	44	15	to	to	TO
cord-328189-jpkxjn6e	44	16	achieve	achieve	VB
cord-328189-jpkxjn6e	44	17	the	the	DT
cord-328189-jpkxjn6e	44	18	affinity	affinity	NN
cord-328189-jpkxjn6e	44	19	that	that	WDT
cord-328189-jpkxjn6e	44	20	is	be	VBZ
cord-328189-jpkxjn6e	44	21	required	require	VBN
cord-328189-jpkxjn6e	44	22	for	for	IN
cord-328189-jpkxjn6e	44	23	effective	effective	JJ
cord-328189-jpkxjn6e	44	24	cell	cell	NN
cord-328189-jpkxjn6e	44	25	entry	entry	NN
cord-328189-jpkxjn6e	44	26	.	.	.
cord-328189-jpkxjn6e	45	1	An	an	DT
cord-328189-jpkxjn6e	45	2	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	45	3	residue	residue	NN
cord-328189-jpkxjn6e	45	4	is	be	VBZ
cord-328189-jpkxjn6e	45	5	considered	consider	VBN
cord-328189-jpkxjn6e	45	6	as	as	IN
cord-328189-jpkxjn6e	45	7	part	part	NN
cord-328189-jpkxjn6e	45	8	of	of	IN
cord-328189-jpkxjn6e	45	9	the	the	DT
cord-328189-jpkxjn6e	45	10	interface	interface	NN
cord-328189-jpkxjn6e	45	11	if	if	IN
cord-328189-jpkxjn6e	45	12	one	one	CD
cord-328189-jpkxjn6e	45	13	of	of	IN
cord-328189-jpkxjn6e	45	14	its	-PRON-	PRP$
cord-328189-jpkxjn6e	45	15	atoms	atom	NNS
cord-328189-jpkxjn6e	45	16	is	be	VBZ
cord-328189-jpkxjn6e	45	17	within	within	IN
cord-328189-jpkxjn6e	45	18	4Å	4å	CD
cord-328189-jpkxjn6e	45	19	from	from	IN
cord-328189-jpkxjn6e	45	20	any	any	DT
cord-328189-jpkxjn6e	45	21	RBD	RBD	NNP
cord-328189-jpkxjn6e	45	22	atom	atom	NN
cord-328189-jpkxjn6e	45	23	in	in	IN
cord-328189-jpkxjn6e	45	24	at	at	RB
cord-328189-jpkxjn6e	45	25	least	least	RBS
cord-328189-jpkxjn6e	45	26	10	10	CD
cord-328189-jpkxjn6e	45	27	%	%	NN
cord-328189-jpkxjn6e	45	28	of	of	IN
cord-328189-jpkxjn6e	45	29	the	the	DT
cord-328189-jpkxjn6e	45	30	10,000	10,000	CD
cord-328189-jpkxjn6e	45	31	MD	MD	NNP
cord-328189-jpkxjn6e	45	32	simulation	simulation	NN
cord-328189-jpkxjn6e	45	33	frames	frame	NNS
cord-328189-jpkxjn6e	45	34	.	.	.
cord-328189-jpkxjn6e	46	1	(	(	-LRB-
cord-328189-jpkxjn6e	46	2	D	D	NNP
cord-328189-jpkxjn6e	46	3	)	)	-RRB-
cord-328189-jpkxjn6e	46	4	Overlay	overlay	NN
cord-328189-jpkxjn6e	46	5	of	of	IN
cord-328189-jpkxjn6e	46	6	50	50	CD
cord-328189-jpkxjn6e	46	7	snapshots	snapshot	NNS
cord-328189-jpkxjn6e	46	8	for	for	IN
cord-328189-jpkxjn6e	46	9	each	each	DT
cord-328189-jpkxjn6e	46	10	of	of	IN
cord-328189-jpkxjn6e	46	11	the	the	DT
cord-328189-jpkxjn6e	46	12	three	three	CD
cord-328189-jpkxjn6e	46	13	RBDs	rbd	NNS
cord-328189-jpkxjn6e	46	14	.	.	.
cord-328189-jpkxjn6e	47	1	The	the	DT
cord-328189-jpkxjn6e	47	2	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	47	3	is	be	VBZ
cord-328189-jpkxjn6e	47	4	in	in	IN
cord-328189-jpkxjn6e	47	5	surface	surface	NN
cord-328189-jpkxjn6e	47	6	representation	representation	NN
cord-328189-jpkxjn6e	47	7	(	(	-LRB-
cord-328189-jpkxjn6e	47	8	gray	gray	JJ
cord-328189-jpkxjn6e	47	9	)	)	-RRB-
cord-328189-jpkxjn6e	47	10	.	.	.
cord-328189-jpkxjn6e	48	1	The	the	DT
cord-328189-jpkxjn6e	48	2	frames	frame	NNS
cord-328189-jpkxjn6e	48	3	were	be	VBD
cord-328189-jpkxjn6e	48	4	aligned	align	VBN
cord-328189-jpkxjn6e	48	5	using	use	VBG
cord-328189-jpkxjn6e	48	6	the	the	DT
cord-328189-jpkxjn6e	48	7	N	n	CD
cord-328189-jpkxjn6e	48	8	-	-	HYPH
cord-328189-jpkxjn6e	48	9	terminal	terminal	NN
cord-328189-jpkxjn6e	48	10	fragment	fragment	NN
cord-328189-jpkxjn6e	48	11	of	of	IN
cord-328189-jpkxjn6e	48	12	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	48	13	that	that	WDT
cord-328189-jpkxjn6e	48	14	contains	contain	VBZ
cord-328189-jpkxjn6e	48	15	the	the	DT
cord-328189-jpkxjn6e	48	16	two	two	CD
cord-328189-jpkxjn6e	48	17	helices	helix	NNS
cord-328189-jpkxjn6e	48	18	participating	participate	VBG
cord-328189-jpkxjn6e	48	19	in	in	IN
cord-328189-jpkxjn6e	48	20	the	the	DT
cord-328189-jpkxjn6e	48	21	RBDs	rbds	NN
cord-328189-jpkxjn6e	48	22	binding	bind	VBG
cord-328189-jpkxjn6e	48	23	.	.	.
cord-328189-jpkxjn6e	49	1	While	while	IN
cord-328189-jpkxjn6e	49	2	the	the	DT
cord-328189-jpkxjn6e	49	3	sequence	sequence	NN
cord-328189-jpkxjn6e	49	4	identity	identity	NN
cord-328189-jpkxjn6e	49	5	between	between	IN
cord-328189-jpkxjn6e	49	6	the	the	DT
cord-328189-jpkxjn6e	49	7	RBDs	RBDs	NNP
cord-328189-jpkxjn6e	49	8	of	of	IN
cord-328189-jpkxjn6e	49	9	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	49	10	and	and	CC
cord-328189-jpkxjn6e	49	11	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	49	12	is	be	VBZ
cord-328189-jpkxjn6e	49	13	73	73	CD
cord-328189-jpkxjn6e	49	14	%	%	NN
cord-328189-jpkxjn6e	49	15	(	(	-LRB-
cord-328189-jpkxjn6e	49	16	Table	table	NN
cord-328189-jpkxjn6e	49	17	1	1	CD
cord-328189-jpkxjn6e	49	18	)	)	-RRB-
cord-328189-jpkxjn6e	49	19	,	,	,
cord-328189-jpkxjn6e	49	20	we	-PRON-	PRP
cord-328189-jpkxjn6e	49	21	observe	observe	VBP
cord-328189-jpkxjn6e	49	22	a	a	DT
cord-328189-jpkxjn6e	49	23	significantly	significantly	RB
cord-328189-jpkxjn6e	49	24	higher	high	JJR
cord-328189-jpkxjn6e	49	25	residue	residue	NN
cord-328189-jpkxjn6e	49	26	substitution	substitution	NN
cord-328189-jpkxjn6e	49	27	rate	rate	NN
cord-328189-jpkxjn6e	49	28	at	at	IN
cord-328189-jpkxjn6e	49	29	the	the	DT
cord-328189-jpkxjn6e	49	30	interaction	interaction	NN
cord-328189-jpkxjn6e	49	31	interface	interface	NN
cord-328189-jpkxjn6e	49	32	with	with	IN
cord-328189-jpkxjn6e	49	33	the	the	DT
cord-328189-jpkxjn6e	49	34	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	49	35	receptor	receptor	NN
cord-328189-jpkxjn6e	49	36	.	.	.
cord-328189-jpkxjn6e	50	1	Out	out	IN
cord-328189-jpkxjn6e	50	2	of	of	IN
cord-328189-jpkxjn6e	50	3	29	29	CD
cord-328189-jpkxjn6e	50	4	RBD	rbd	NN
cord-328189-jpkxjn6e	50	5	interface	interface	NN
cord-328189-jpkxjn6e	50	6	residues	residue	NNS
cord-328189-jpkxjn6e	50	7	,	,	,
cord-328189-jpkxjn6e	50	8	only	only	RB
cord-328189-jpkxjn6e	50	9	10	10	CD
cord-328189-jpkxjn6e	50	10	residues	residue	NNS
cord-328189-jpkxjn6e	50	11	(	(	-LRB-
cord-328189-jpkxjn6e	50	12	34	34	CD
cord-328189-jpkxjn6e	50	13	%	%	NN
cord-328189-jpkxjn6e	50	14	)	)	-RRB-
cord-328189-jpkxjn6e	50	15	in	in	IN
cord-328189-jpkxjn6e	50	16	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	50	17	are	be	VBP
cord-328189-jpkxjn6e	50	18	conserved	conserve	VBN
cord-328189-jpkxjn6e	50	19	with	with	IN
cord-328189-jpkxjn6e	50	20	respect	respect	NN
cord-328189-jpkxjn6e	50	21	to	to	IN
cord-328189-jpkxjn6e	50	22	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	51	1	(	(	-LRB-
cord-328189-jpkxjn6e	51	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	51	3	.	.	.
cord-328189-jpkxjn6e	51	4	2A	2a	CD
cord-328189-jpkxjn6e	51	5	,	,	,
cord-328189-jpkxjn6e	51	6	Table	Table	NNP
cord-328189-jpkxjn6e	51	7	S1	S1	NNP
cord-328189-jpkxjn6e	51	8	,	,	,
cord-328189-jpkxjn6e	51	9	Fig	Fig	NNP
cord-328189-jpkxjn6e	51	10	.	.	.
cord-328189-jpkxjn6e	51	11	S1	S1	NNP
cord-328189-jpkxjn6e	51	12	)	)	-RRB-
cord-328189-jpkxjn6e	51	13	.	.	.
cord-328189-jpkxjn6e	52	1	Similarly	similarly	RB
cord-328189-jpkxjn6e	52	2	,	,	,
cord-328189-jpkxjn6e	52	3	only	only	RB
cord-328189-jpkxjn6e	52	4	12	12	CD
cord-328189-jpkxjn6e	52	5	residues	residue	NNS
cord-328189-jpkxjn6e	52	6	(	(	-LRB-
cord-328189-jpkxjn6e	52	7	40	40	CD
cord-328189-jpkxjn6e	52	8	%	%	NN
cord-328189-jpkxjn6e	52	9	)	)	-RRB-
cord-328189-jpkxjn6e	52	10	in	in	IN
cord-328189-jpkxjn6e	52	11	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	52	12	are	be	VBP
cord-328189-jpkxjn6e	52	13	conserved	conserve	VBN
cord-328189-jpkxjn6e	52	14	with	with	IN
cord-328189-jpkxjn6e	52	15	respect	respect	NN
cord-328189-jpkxjn6e	52	16	to	to	IN
cord-328189-jpkxjn6e	52	17	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	52	18	.	.	.
cord-328189-jpkxjn6e	53	1	To	to	TO
cord-328189-jpkxjn6e	53	2	investigate	investigate	VB
cord-328189-jpkxjn6e	53	3	these	these	DT
cord-328189-jpkxjn6e	53	4	interface	interface	NN
cord-328189-jpkxjn6e	53	5	residues	residue	NNS
cord-328189-jpkxjn6e	53	6	,	,	,
cord-328189-jpkxjn6e	53	7	we	-PRON-	PRP
cord-328189-jpkxjn6e	53	8	construct	construct	VBP
cord-328189-jpkxjn6e	53	9	and	and	CC
cord-328189-jpkxjn6e	53	10	overlay	overlay	VBP
cord-328189-jpkxjn6e	53	11	the	the	DT
cord-328189-jpkxjn6e	53	12	contact	contact	NN
cord-328189-jpkxjn6e	53	13	maps	map	NNS
cord-328189-jpkxjn6e	53	14	for	for	IN
cord-328189-jpkxjn6e	53	15	the	the	DT
cord-328189-jpkxjn6e	53	16	RBD	RBD	NNP
cord-328189-jpkxjn6e	53	17	-	-	HYPH
cord-328189-jpkxjn6e	53	18	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	53	19	interfaces	interface	NNS
cord-328189-jpkxjn6e	53	20	for	for	IN
cord-328189-jpkxjn6e	53	21	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	53	22	and	and	CC
cord-328189-jpkxjn6e	53	23	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	53	24	(	(	-LRB-
cord-328189-jpkxjn6e	53	25	Fig	Fig	NNP
cord-328189-jpkxjn6e	53	26	.	.	.
cord-328189-jpkxjn6e	53	27	2B	2b	CD
cord-328189-jpkxjn6e	53	28	)	)	-RRB-
cord-328189-jpkxjn6e	53	29	.	.	.
cord-328189-jpkxjn6e	54	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	54	2	define	define	VBP
cord-328189-jpkxjn6e	54	3	a	a	DT
cord-328189-jpkxjn6e	54	4	residue	residue	NN
cord-328189-jpkxjn6e	54	5	-	-	HYPH
cord-328189-jpkxjn6e	54	6	residue	residue	NN
cord-328189-jpkxjn6e	54	7	contact	contact	NN
cord-328189-jpkxjn6e	54	8	frequency	frequency	NN
cord-328189-jpkxjn6e	54	9	(	(	-LRB-
cord-328189-jpkxjn6e	54	10	CF	CF	NNP
cord-328189-jpkxjn6e	54	11	)	)	-RRB-
cord-328189-jpkxjn6e	54	12	as	as	IN
cord-328189-jpkxjn6e	54	13	the	the	DT
cord-328189-jpkxjn6e	54	14	fraction	fraction	NN
cord-328189-jpkxjn6e	54	15	of	of	IN
cord-328189-jpkxjn6e	54	16	MD	MD	NNP
cord-328189-jpkxjn6e	54	17	trajectory	trajectory	NN
cord-328189-jpkxjn6e	54	18	frames	frame	NNS
cord-328189-jpkxjn6e	54	19	in	in	IN
cord-328189-jpkxjn6e	54	20	which	which	WDT
cord-328189-jpkxjn6e	54	21	the	the	DT
cord-328189-jpkxjn6e	54	22	contact	contact	NN
cord-328189-jpkxjn6e	54	23	appears	appear	VBZ
cord-328189-jpkxjn6e	54	24	.	.	.
cord-328189-jpkxjn6e	55	1	Remarkably	remarkably	RB
cord-328189-jpkxjn6e	55	2	,	,	,
cord-328189-jpkxjn6e	55	3	only	only	RB
cord-328189-jpkxjn6e	55	4	8	8	CD
cord-328189-jpkxjn6e	55	5	out	out	IN
cord-328189-jpkxjn6e	55	6	of	of	IN
cord-328189-jpkxjn6e	55	7	the	the	DT
cord-328189-jpkxjn6e	55	8	total	total	JJ
cord-328189-jpkxjn6e	55	9	72	72	CD
cord-328189-jpkxjn6e	55	10	residue	residue	NN
cord-328189-jpkxjn6e	55	11	-	-	HYPH
cord-328189-jpkxjn6e	55	12	residue	residue	NN
cord-328189-jpkxjn6e	55	13	interface	interface	NN
cord-328189-jpkxjn6e	55	14	contacts	contact	NNS
cord-328189-jpkxjn6e	55	15	have	have	VBP
cord-328189-jpkxjn6e	55	16	comparable	comparable	JJ
cord-328189-jpkxjn6e	55	17	(	(	-LRB-
cord-328189-jpkxjn6e	55	18	<	<	XX
cord-328189-jpkxjn6e	55	19	50	50	CD
cord-328189-jpkxjn6e	55	20	%	%	NN
cord-328189-jpkxjn6e	55	21	difference	difference	NN
cord-328189-jpkxjn6e	55	22	)	)	-RRB-
cord-328189-jpkxjn6e	56	1	contact	contact	NN
cord-328189-jpkxjn6e	56	2	frequencies	frequency	NNS
cord-328189-jpkxjn6e	56	3	between	between	IN
cord-328189-jpkxjn6e	56	4	the	the	DT
cord-328189-jpkxjn6e	56	5	COVID-19-ACE2	covid-19-ace2	CD
cord-328189-jpkxjn6e	56	6	and	and	CC
cord-328189-jpkxjn6e	56	7	SARS-2002-ACE2	sars-2002-ace2	JJ
cord-328189-jpkxjn6e	56	8	interfaces	interface	NNS
cord-328189-jpkxjn6e	56	9	(	(	-LRB-
cord-328189-jpkxjn6e	56	10	Fig	Fig	NNP
cord-328189-jpkxjn6e	56	11	.	.	.
cord-328189-jpkxjn6e	56	12	2B	2b	CD
cord-328189-jpkxjn6e	56	13	,	,	,
cord-328189-jpkxjn6e	56	14	colored	color	VBN
cord-328189-jpkxjn6e	56	15	gray	gray	NN
cord-328189-jpkxjn6e	56	16	)	)	-RRB-
cord-328189-jpkxjn6e	56	17	.	.	.
cord-328189-jpkxjn6e	57	1	Furthermore	furthermore	RB
cord-328189-jpkxjn6e	57	2	,	,	,
cord-328189-jpkxjn6e	57	3	we	-PRON-	PRP
cord-328189-jpkxjn6e	57	4	find	find	VBP
cord-328189-jpkxjn6e	57	5	two	two	CD
cord-328189-jpkxjn6e	57	6	interaction	interaction	NN
cord-328189-jpkxjn6e	57	7	patches	patch	NNS
cord-328189-jpkxjn6e	57	8	unique	unique	JJ
cord-328189-jpkxjn6e	57	9	to	to	IN
cord-328189-jpkxjn6e	57	10	COVID-19	covid-19	VB
cord-328189-jpkxjn6e	58	1	(	(	-LRB-
cord-328189-jpkxjn6e	58	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	58	3	.	.	.
cord-328189-jpkxjn6e	58	4	2B	2b	CD
cord-328189-jpkxjn6e	58	5	,	,	,
cord-328189-jpkxjn6e	58	6	patches	patch	NNS
cord-328189-jpkxjn6e	58	7	1	1	CD
cord-328189-jpkxjn6e	58	8	and	and	CC
cord-328189-jpkxjn6e	58	9	3	3	CD
cord-328189-jpkxjn6e	58	10	)	)	-RRB-
cord-328189-jpkxjn6e	58	11	and	and	CC
cord-328189-jpkxjn6e	58	12	another	another	DT
cord-328189-jpkxjn6e	58	13	patch	patch	NN
cord-328189-jpkxjn6e	58	14	unique	unique	JJ
cord-328189-jpkxjn6e	58	15	to	to	IN
cord-328189-jpkxjn6e	58	16	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	59	1	(	(	-LRB-
cord-328189-jpkxjn6e	59	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	59	3	.	.	.
cord-328189-jpkxjn6e	59	4	2B	2B	NNP
cord-328189-jpkxjn6e	59	5	,	,	,
cord-328189-jpkxjn6e	59	6	patch	patch	NN
cord-328189-jpkxjn6e	59	7	2	2	CD
cord-328189-jpkxjn6e	59	8	)	)	-RRB-
cord-328189-jpkxjn6e	59	9	.	.	.
cord-328189-jpkxjn6e	60	1	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	60	2	has	have	VBZ
cord-328189-jpkxjn6e	60	3	a	a	DT
cord-328189-jpkxjn6e	60	4	significant	significant	JJ
cord-328189-jpkxjn6e	60	5	and	and	CC
cord-328189-jpkxjn6e	60	6	unique	unique	JJ
cord-328189-jpkxjn6e	60	7	contact	contact	NN
cord-328189-jpkxjn6e	60	8	site	site	NN
cord-328189-jpkxjn6e	60	9	between	between	IN
cord-328189-jpkxjn6e	60	10	residues	residue	NNS
cord-328189-jpkxjn6e	60	11	500	500	CD
cord-328189-jpkxjn6e	60	12	-	-	SYM
cord-328189-jpkxjn6e	60	13	505	505	CD
cord-328189-jpkxjn6e	60	14	of	of	IN
cord-328189-jpkxjn6e	60	15	the	the	DT
cord-328189-jpkxjn6e	60	16	RBD	RBD	NNP
cord-328189-jpkxjn6e	60	17	and	and	CC
cord-328189-jpkxjn6e	60	18	residues	residue	VBZ
cord-328189-jpkxjn6e	60	19	353	353	CD
cord-328189-jpkxjn6e	60	20	-	-	HYPH
cord-328189-jpkxjn6e	60	21	357	357	CD
cord-328189-jpkxjn6e	60	22	of	of	IN
cord-328189-jpkxjn6e	60	23	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	61	1	(	(	-LRB-
cord-328189-jpkxjn6e	61	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	61	3	.	.	NNP
cord-328189-jpkxjn6e	61	4	2	2	CD
cord-328189-jpkxjn6e	61	5	,	,	,
cord-328189-jpkxjn6e	61	6	B	b	NN
cord-328189-jpkxjn6e	61	7	and	and	CC
cord-328189-jpkxjn6e	61	8	C	C	NNP
cord-328189-jpkxjn6e	61	9	)	)	-RRB-
cord-328189-jpkxjn6e	61	10	.	.	.
cord-328189-jpkxjn6e	62	1	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	62	2	also	also	RB
cord-328189-jpkxjn6e	62	3	creates	create	VBZ
cord-328189-jpkxjn6e	62	4	a	a	DT
cord-328189-jpkxjn6e	62	5	new	new	JJ
cord-328189-jpkxjn6e	62	6	interaction	interaction	NN
cord-328189-jpkxjn6e	62	7	patch	patch	NN
cord-328189-jpkxjn6e	62	8	with	with	IN
cord-328189-jpkxjn6e	62	9	the	the	DT
cord-328189-jpkxjn6e	62	10	middle	middle	NN
cord-328189-jpkxjn6e	62	11	of	of	IN
cord-328189-jpkxjn6e	62	12	the	the	DT
cord-328189-jpkxjn6e	62	13	N	N	NNP
cord-328189-jpkxjn6e	62	14	-	-	HYPH
cord-328189-jpkxjn6e	62	15	terminal	terminal	NN
cord-328189-jpkxjn6e	62	16	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	62	17	helix	helix	NN
cord-328189-jpkxjn6e	63	1	(	(	-LRB-
cord-328189-jpkxjn6e	63	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	63	3	.	.	NNP
cord-328189-jpkxjn6e	63	4	2	2	CD
cord-328189-jpkxjn6e	63	5	,	,	,
cord-328189-jpkxjn6e	63	6	B	b	NN
cord-328189-jpkxjn6e	63	7	and	and	CC
cord-328189-jpkxjn6e	63	8	C	C	NNP
cord-328189-jpkxjn6e	63	9	)	)	-RRB-
cord-328189-jpkxjn6e	63	10	,	,	,
cord-328189-jpkxjn6e	63	11	while	while	IN
cord-328189-jpkxjn6e	63	12	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	63	13	has	have	VBZ
cord-328189-jpkxjn6e	63	14	a	a	DT
cord-328189-jpkxjn6e	63	15	unique	unique	JJ
cord-328189-jpkxjn6e	63	16	interaction	interaction	NN
cord-328189-jpkxjn6e	63	17	patch	patch	NN
cord-328189-jpkxjn6e	63	18	with	with	IN
cord-328189-jpkxjn6e	63	19	the	the	DT
cord-328189-jpkxjn6e	63	20	end	end	NN
cord-328189-jpkxjn6e	63	21	of	of	IN
cord-328189-jpkxjn6e	63	22	the	the	DT
cord-328189-jpkxjn6e	63	23	same	same	JJ
cord-328189-jpkxjn6e	63	24	helix	helix	NN
cord-328189-jpkxjn6e	63	25	(	(	-LRB-
cord-328189-jpkxjn6e	63	26	Fig	Fig	NNP
cord-328189-jpkxjn6e	63	27	.	.	NNP
cord-328189-jpkxjn6e	63	28	2	2	CD
cord-328189-jpkxjn6e	63	29	,	,	,
cord-328189-jpkxjn6e	63	30	B	b	NN
cord-328189-jpkxjn6e	63	31	and	and	CC
cord-328189-jpkxjn6e	63	32	C	C	NNP
cord-328189-jpkxjn6e	63	33	)	)	-RRB-
cord-328189-jpkxjn6e	63	34	.	.	.
cord-328189-jpkxjn6e	64	1	The	the	DT
cord-328189-jpkxjn6e	64	2	rest	rest	NN
cord-328189-jpkxjn6e	64	3	of	of	IN
cord-328189-jpkxjn6e	64	4	the	the	DT
cord-328189-jpkxjn6e	64	5	changes	change	NNS
cord-328189-jpkxjn6e	64	6	in	in	IN
cord-328189-jpkxjn6e	64	7	the	the	DT
cord-328189-jpkxjn6e	64	8	interface	interface	NN
cord-328189-jpkxjn6e	64	9	contact	contact	NN
cord-328189-jpkxjn6e	64	10	frequencies	frequency	NNS
cord-328189-jpkxjn6e	64	11	are	be	VBP
cord-328189-jpkxjn6e	64	12	due	due	JJ
cord-328189-jpkxjn6e	64	13	to	to	IN
cord-328189-jpkxjn6e	64	14	the	the	DT
cord-328189-jpkxjn6e	64	15	different	different	JJ
cord-328189-jpkxjn6e	64	16	interface	interface	NN
cord-328189-jpkxjn6e	64	17	loop	loop	NN
cord-328189-jpkxjn6e	64	18	conformations	conformation	NNS
cord-328189-jpkxjn6e	64	19	(	(	-LRB-
cord-328189-jpkxjn6e	64	20	COVID-19	covid-19	JJ
cord-328189-jpkxjn6e	64	21	residue	residue	NN
cord-328189-jpkxjn6e	64	22	numbers	number	NNS
cord-328189-jpkxjn6e	64	23	474	474	CD
cord-328189-jpkxjn6e	64	24	-	-	SYM
cord-328189-jpkxjn6e	64	25	498	498	CD
cord-328189-jpkxjn6e	64	26	,	,	,
cord-328189-jpkxjn6e	64	27	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	64	28	residue	residue	NN
cord-328189-jpkxjn6e	64	29	numbers	number	NNS
cord-328189-jpkxjn6e	64	30	461	461	CD
cord-328189-jpkxjn6e	64	31	-	-	SYM
cord-328189-jpkxjn6e	64	32	484	484	CD
cord-328189-jpkxjn6e	64	33	)	)	-RRB-
cord-328189-jpkxjn6e	64	34	(	(	-LRB-
cord-328189-jpkxjn6e	64	35	Fig	Fig	NNP
cord-328189-jpkxjn6e	64	36	.	.	NNP
cord-328189-jpkxjn6e	64	37	2	2	CD
cord-328189-jpkxjn6e	64	38	,	,	,
cord-328189-jpkxjn6e	64	39	A	a	NN
cord-328189-jpkxjn6e	64	40	and	and	CC
cord-328189-jpkxjn6e	64	41	B	b	NN
cord-328189-jpkxjn6e	64	42	,	,	,
cord-328189-jpkxjn6e	64	43	Table	Table	NNP
cord-328189-jpkxjn6e	64	44	S1	S1	NNP
cord-328189-jpkxjn6e	64	45	)	)	-RRB-
cord-328189-jpkxjn6e	64	46	.	.	.
cord-328189-jpkxjn6e	65	1	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	65	2	has	have	VBZ
cord-328189-jpkxjn6e	65	3	a	a	DT
cord-328189-jpkxjn6e	65	4	significantly	significantly	RB
cord-328189-jpkxjn6e	65	5	higher	high	JJR
cord-328189-jpkxjn6e	65	6	number	number	NN
cord-328189-jpkxjn6e	65	7	of	of	IN
cord-328189-jpkxjn6e	65	8	well	well	RB
cord-328189-jpkxjn6e	65	9	-	-	HYPH
cord-328189-jpkxjn6e	65	10	defined	define	VBN
cord-328189-jpkxjn6e	65	11	contact	contact	NN
cord-328189-jpkxjn6e	65	12	pairs	pair	NNS
cord-328189-jpkxjn6e	65	13	compared	compare	VBN
cord-328189-jpkxjn6e	65	14	to	to	IN
cord-328189-jpkxjn6e	65	15	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	65	16	:	:	:
cord-328189-jpkxjn6e	65	17	52	52	CD
cord-328189-jpkxjn6e	65	18	vs.	vs.	IN
cord-328189-jpkxjn6e	65	19	28	28	CD
cord-328189-jpkxjn6e	65	20	contacts	contact	NNS
cord-328189-jpkxjn6e	65	21	(	(	-LRB-
cord-328189-jpkxjn6e	65	22	with	with	IN
cord-328189-jpkxjn6e	65	23	44	44	CD
cord-328189-jpkxjn6e	65	24	and	and	CC
cord-328189-jpkxjn6e	65	25	20	20	CD
cord-328189-jpkxjn6e	65	26	unique	unique	JJ
cord-328189-jpkxjn6e	65	27	pairs	pair	NNS
cord-328189-jpkxjn6e	65	28	,	,	,
cord-328189-jpkxjn6e	65	29	excluding	exclude	VBG
cord-328189-jpkxjn6e	65	30	the	the	DT
cord-328189-jpkxjn6e	65	31	ones	one	NNS
cord-328189-jpkxjn6e	65	32	with	with	IN
cord-328189-jpkxjn6e	65	33	similar	similar	JJ
cord-328189-jpkxjn6e	65	34	CFs	cf	NNS
cord-328189-jpkxjn6e	65	35	)	)	-RRB-
cord-328189-jpkxjn6e	65	36	were	be	VBD
cord-328189-jpkxjn6e	65	37	found	find	VBN
cord-328189-jpkxjn6e	65	38	for	for	IN
cord-328189-jpkxjn6e	65	39	RBD	RBD	NNP
cord-328189-jpkxjn6e	65	40	-	-	HYPH
cord-328189-jpkxjn6e	65	41	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	65	42	of	of	IN
cord-328189-jpkxjn6e	65	43	the	the	DT
cord-328189-jpkxjn6e	65	44	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	65	45	and	and	CC
cord-328189-jpkxjn6e	65	46	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	65	47	,	,	,
cord-328189-jpkxjn6e	65	48	respectively	respectively	RB
cord-328189-jpkxjn6e	65	49	(	(	-LRB-
cord-328189-jpkxjn6e	65	50	Fig	Fig	NNP
cord-328189-jpkxjn6e	65	51	.	.	.
cord-328189-jpkxjn6e	65	52	2B	2b	CD
cord-328189-jpkxjn6e	65	53	)	)	-RRB-
cord-328189-jpkxjn6e	65	54	.	.	.
cord-328189-jpkxjn6e	66	1	Results	result	NNS
cord-328189-jpkxjn6e	66	2	from	from	IN
cord-328189-jpkxjn6e	66	3	Fig	Fig	NNP
cord-328189-jpkxjn6e	66	4	.	.	.
cord-328189-jpkxjn6e	67	1	2	2	LS
cord-328189-jpkxjn6e	67	2	expose	expose	VBP
cord-328189-jpkxjn6e	67	3	the	the	DT
cord-328189-jpkxjn6e	67	4	accelerated	accelerated	JJ
cord-328189-jpkxjn6e	67	5	evolution	evolution	NN
cord-328189-jpkxjn6e	67	6	among	among	IN
cord-328189-jpkxjn6e	67	7	the	the	DT
cord-328189-jpkxjn6e	67	8	key	key	JJ
cord-328189-jpkxjn6e	67	9	anchoring	anchor	VBG
cord-328189-jpkxjn6e	67	10	residues	residue	NNS
cord-328189-jpkxjn6e	67	11	of	of	IN
cord-328189-jpkxjn6e	67	12	the	the	DT
cord-328189-jpkxjn6e	67	13	RBD	RBD	NNP
cord-328189-jpkxjn6e	67	14	-	-	HYPH
cord-328189-jpkxjn6e	67	15	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	67	16	interface	interface	NN
cord-328189-jpkxjn6e	67	17	.	.	.
cord-328189-jpkxjn6e	68	1	This	this	DT
cord-328189-jpkxjn6e	68	2	comparison	comparison	NN
cord-328189-jpkxjn6e	68	3	raises	raise	VBZ
cord-328189-jpkxjn6e	68	4	the	the	DT
cord-328189-jpkxjn6e	68	5	following	following	JJ
cord-328189-jpkxjn6e	68	6	question	question	NN
cord-328189-jpkxjn6e	68	7	:	:	:
cord-328189-jpkxjn6e	68	8	How	how	WRB
cord-328189-jpkxjn6e	68	9	does	do	VBZ
cord-328189-jpkxjn6e	68	10	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	68	11	RBD	RBD	NNP
cord-328189-jpkxjn6e	68	12	reach	reach	VB
cord-328189-jpkxjn6e	68	13	an	an	DT
cord-328189-jpkxjn6e	68	14	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	68	15	binding	binding	NN
cord-328189-jpkxjn6e	68	16	affinity	affinity	NN
cord-328189-jpkxjn6e	68	17	that	that	WDT
cord-328189-jpkxjn6e	68	18	is	be	VBZ
cord-328189-jpkxjn6e	68	19	comparable	comparable	JJ
cord-328189-jpkxjn6e	68	20	to	to	IN
cord-328189-jpkxjn6e	68	21	that	that	DT
cord-328189-jpkxjn6e	68	22	of	of	IN
cord-328189-jpkxjn6e	68	23	COVID-19	covid-19	CD
cord-328189-jpkxjn6e	68	24	but	but	CC
cord-328189-jpkxjn6e	68	25	with	with	IN
cord-328189-jpkxjn6e	68	26	fewer	few	JJR
cord-328189-jpkxjn6e	68	27	contact	contact	NN
cord-328189-jpkxjn6e	68	28	pairs	pair	NNS
cord-328189-jpkxjn6e	68	29	and	and	CC
cord-328189-jpkxjn6e	68	30	a	a	DT
cord-328189-jpkxjn6e	68	31	smaller	small	JJR
cord-328189-jpkxjn6e	68	32	interface	interface	NN
cord-328189-jpkxjn6e	68	33	area	area	NN
cord-328189-jpkxjn6e	68	34	?	?	.
cord-328189-jpkxjn6e	69	1	The	the	DT
cord-328189-jpkxjn6e	69	2	distribution	distribution	NN
cord-328189-jpkxjn6e	69	3	of	of	IN
cord-328189-jpkxjn6e	69	4	SOAP	soap	NN
cord-328189-jpkxjn6e	69	5	scores	score	NNS
cord-328189-jpkxjn6e	69	6	throughout	throughout	IN
cord-328189-jpkxjn6e	69	7	the	the	DT
cord-328189-jpkxjn6e	69	8	simulation	simulation	NN
cord-328189-jpkxjn6e	69	9	trajectory	trajectory	NN
cord-328189-jpkxjn6e	69	10	has	have	VBZ
cord-328189-jpkxjn6e	69	11	a	a	DT
cord-328189-jpkxjn6e	69	12	larger	large	JJR
cord-328189-jpkxjn6e	69	13	fluctuation	fluctuation	NN
cord-328189-jpkxjn6e	69	14	range	range	NN
cord-328189-jpkxjn6e	69	15	for	for	IN
cord-328189-jpkxjn6e	69	16	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	69	17	,	,	,
cord-328189-jpkxjn6e	69	18	relative	relative	JJ
cord-328189-jpkxjn6e	69	19	to	to	IN
cord-328189-jpkxjn6e	69	20	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	69	21	(	(	-LRB-
cord-328189-jpkxjn6e	69	22	Fig	Fig	NNP
cord-328189-jpkxjn6e	69	23	.	.	.
cord-328189-jpkxjn6e	70	1	1	1	LS
cord-328189-jpkxjn6e	70	2	,	,	,
cord-328189-jpkxjn6e	70	3	A	a	NN
cord-328189-jpkxjn6e	70	4	and	and	CC
cord-328189-jpkxjn6e	70	5	B	b	NN
cord-328189-jpkxjn6e	70	6	;	;	:
cord-328189-jpkxjn6e	70	7	Fig	Fig	NNP
cord-328189-jpkxjn6e	70	8	.	.	.
cord-328189-jpkxjn6e	71	1	S2A	S2A	NNP
cord-328189-jpkxjn6e	71	2	)	)	-RRB-
cord-328189-jpkxjn6e	71	3	suggesting	suggest	VBG
cord-328189-jpkxjn6e	71	4	that	that	IN
cord-328189-jpkxjn6e	71	5	SARS-2002-ACE2	sars-2002-ace2	JJ
cord-328189-jpkxjn6e	71	6	interaction	interaction	NN
cord-328189-jpkxjn6e	71	7	is	be	VBZ
cord-328189-jpkxjn6e	71	8	fluctuating	fluctuate	VBG
cord-328189-jpkxjn6e	71	9	between	between	IN
cord-328189-jpkxjn6e	71	10	several	several	JJ
cord-328189-jpkxjn6e	71	11	structural	structural	JJ
cord-328189-jpkxjn6e	71	12	states	state	NNS
cord-328189-jpkxjn6e	71	13	.	.	.
cord-328189-jpkxjn6e	72	1	Moreover	moreover	RB
cord-328189-jpkxjn6e	72	2	,	,	,
cord-328189-jpkxjn6e	72	3	analysis	analysis	NN
cord-328189-jpkxjn6e	72	4	of	of	IN
cord-328189-jpkxjn6e	72	5	contact	contact	NN
cord-328189-jpkxjn6e	72	6	frequencies	frequency	NNS
cord-328189-jpkxjn6e	72	7	along	along	IN
cord-328189-jpkxjn6e	72	8	the	the	DT
cord-328189-jpkxjn6e	72	9	entire	entire	JJ
cord-328189-jpkxjn6e	72	10	trajectory	trajectory	NN
cord-328189-jpkxjn6e	72	11	reveals	reveal	VBZ
cord-328189-jpkxjn6e	72	12	that	that	IN
cord-328189-jpkxjn6e	72	13	none	none	NN
cord-328189-jpkxjn6e	72	14	of	of	IN
cord-328189-jpkxjn6e	72	15	the	the	DT
cord-328189-jpkxjn6e	72	16	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	72	17	contacts	contact	NNS
cord-328189-jpkxjn6e	72	18	are	be	VBP
cord-328189-jpkxjn6e	72	19	maintained	maintain	VBN
cord-328189-jpkxjn6e	72	20	over	over	IN
cord-328189-jpkxjn6e	72	21	90	90	CD
cord-328189-jpkxjn6e	72	22	%	%	NN
cord-328189-jpkxjn6e	72	23	of	of	IN
cord-328189-jpkxjn6e	72	24	the	the	DT
cord-328189-jpkxjn6e	72	25	frames	frame	NNS
cord-328189-jpkxjn6e	72	26	while	while	IN
cord-328189-jpkxjn6e	72	27	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	72	28	still	still	RB
cord-328189-jpkxjn6e	72	29	maintains	maintain	VBZ
cord-328189-jpkxjn6e	72	30	about	about	IN
cord-328189-jpkxjn6e	72	31	half	half	NN
cord-328189-jpkxjn6e	72	32	of	of	IN
cord-328189-jpkxjn6e	72	33	its	-PRON-	PRP$
cord-328189-jpkxjn6e	72	34	contacts	contact	NNS
cord-328189-jpkxjn6e	72	35	at	at	IN
cord-328189-jpkxjn6e	72	36	90	90	CD
cord-328189-jpkxjn6e	72	37	%	%	NN
cord-328189-jpkxjn6e	72	38	of	of	IN
cord-328189-jpkxjn6e	72	39	the	the	DT
cord-328189-jpkxjn6e	72	40	trajectory	trajectory	NN
cord-328189-jpkxjn6e	72	41	(	(	-LRB-
cord-328189-jpkxjn6e	72	42	Fig	Fig	NNP
cord-328189-jpkxjn6e	72	43	.	.	.
cord-328189-jpkxjn6e	72	44	S2B	s2b	NN
cord-328189-jpkxjn6e	72	45	)	)	-RRB-
cord-328189-jpkxjn6e	72	46	.	.	.
cord-328189-jpkxjn6e	73	1	To	to	TO
cord-328189-jpkxjn6e	73	2	investigate	investigate	VB
cord-328189-jpkxjn6e	73	3	the	the	DT
cord-328189-jpkxjn6e	73	4	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	73	5	of	of	IN
cord-328189-jpkxjn6e	73	6	COVID-19	covid-19	JJ
cord-328189-jpkxjn6e	73	7	binding	binding	NN
cord-328189-jpkxjn6e	73	8	compared	compare	VBN
cord-328189-jpkxjn6e	73	9	to	to	IN
cord-328189-jpkxjn6e	73	10	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	73	11	,	,	,
cord-328189-jpkxjn6e	73	12	we	-PRON-	PRP
cord-328189-jpkxjn6e	73	13	calculate	calculate	VBP
cord-328189-jpkxjn6e	73	14	the	the	DT
cord-328189-jpkxjn6e	73	15	root	root	NN
cord-328189-jpkxjn6e	73	16	-	-	HYPH
cord-328189-jpkxjn6e	73	17	mean	mean	JJ
cord-328189-jpkxjn6e	73	18	-	-	HYPH
cord-328189-jpkxjn6e	73	19	square	square	JJ
cord-328189-jpkxjn6e	73	20	fluctuation	fluctuation	NN
cord-328189-jpkxjn6e	73	21	(	(	-LRB-
cord-328189-jpkxjn6e	73	22	RMSF	RMSF	NNP
cord-328189-jpkxjn6e	73	23	)	)	-RRB-
cord-328189-jpkxjn6e	73	24	of	of	IN
cord-328189-jpkxjn6e	73	25	each	each	DT
cord-328189-jpkxjn6e	73	26	residue	residue	NN
cord-328189-jpkxjn6e	73	27	with	with	IN
cord-328189-jpkxjn6e	73	28	respect	respect	NN
cord-328189-jpkxjn6e	73	29	to	to	IN
cord-328189-jpkxjn6e	73	30	the	the	DT
cord-328189-jpkxjn6e	73	31	lowest	low	JJS
cord-328189-jpkxjn6e	73	32	energy	energy	NN
cord-328189-jpkxjn6e	73	33	snapshot	snapshot	NN
cord-328189-jpkxjn6e	73	34	from	from	IN
cord-328189-jpkxjn6e	73	35	their	-PRON-	PRP$
cord-328189-jpkxjn6e	73	36	respective	respective	JJ
cord-328189-jpkxjn6e	73	37	100ns	100ns	JJ
cord-328189-jpkxjn6e	73	38	MD	MD	NNP
cord-328189-jpkxjn6e	73	39	simulation	simulation	NN
cord-328189-jpkxjn6e	73	40	trajectory	trajectory	NN
cord-328189-jpkxjn6e	73	41	.	.	.
cord-328189-jpkxjn6e	74	1	The	the	DT
cord-328189-jpkxjn6e	74	2	interface	interface	NN
cord-328189-jpkxjn6e	74	3	region	region	NN
cord-328189-jpkxjn6e	74	4	in	in	IN
cord-328189-jpkxjn6e	74	5	the	the	DT
cord-328189-jpkxjn6e	74	6	RBD	RBD	NNP
cord-328189-jpkxjn6e	74	7	contains	contain	VBZ
cord-328189-jpkxjn6e	74	8	two	two	CD
cord-328189-jpkxjn6e	74	9	loops	loop	NNS
cord-328189-jpkxjn6e	74	10	(	(	-LRB-
cord-328189-jpkxjn6e	74	11	loop1	loop1	NN
cord-328189-jpkxjn6e	74	12	:	:	:
cord-328189-jpkxjn6e	74	13	residues	residue	NNS
cord-328189-jpkxjn6e	74	14	474	474	CD
cord-328189-jpkxjn6e	74	15	-	-	SYM
cord-328189-jpkxjn6e	74	16	489	489	CD
cord-328189-jpkxjn6e	74	17	,	,	,
cord-328189-jpkxjn6e	74	18	loop2	loop2	NN
cord-328189-jpkxjn6e	74	19	:	:	:
cord-328189-jpkxjn6e	74	20	residues	residue	NNS
cord-328189-jpkxjn6e	74	21	498	498	CD
cord-328189-jpkxjn6e	74	22	-	-	SYM
cord-328189-jpkxjn6e	74	23	505	505	CD
cord-328189-jpkxjn6e	74	24	;	;	:
cord-328189-jpkxjn6e	74	25	using	use	VBG
cord-328189-jpkxjn6e	74	26	COVID-19	covid-19	JJ
cord-328189-jpkxjn6e	74	27	numbering	numbering	NN
cord-328189-jpkxjn6e	74	28	,	,	,
cord-328189-jpkxjn6e	74	29	Fig	Fig	NNP
cord-328189-jpkxjn6e	74	30	.	.	.
cord-328189-jpkxjn6e	74	31	 	 	_SP
cord-328189-jpkxjn6e	75	1	3D	3D	NNP
cord-328189-jpkxjn6e	75	2	)	)	-RRB-
cord-328189-jpkxjn6e	75	3	that	that	WDT
cord-328189-jpkxjn6e	75	4	bind	bind	VBP
cord-328189-jpkxjn6e	75	5	to	to	IN
cord-328189-jpkxjn6e	75	6	the	the	DT
cord-328189-jpkxjn6e	75	7	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	75	8	N	N	NNP
cord-328189-jpkxjn6e	75	9	-	-	HYPH
cord-328189-jpkxjn6e	75	10	terminal	terminal	JJ
cord-328189-jpkxjn6e	75	11	helix	helix	NN
cord-328189-jpkxjn6e	75	12	on	on	IN
cord-328189-jpkxjn6e	75	13	both	both	DT
cord-328189-jpkxjn6e	75	14	of	of	IN
cord-328189-jpkxjn6e	75	15	its	-PRON-	PRP$
cord-328189-jpkxjn6e	75	16	ends	end	NNS
cord-328189-jpkxjn6e	75	17	.	.	.
cord-328189-jpkxjn6e	76	1	These	these	DT
cord-328189-jpkxjn6e	76	2	two	two	CD
cord-328189-jpkxjn6e	76	3	loops	loop	NNS
cord-328189-jpkxjn6e	76	4	are	be	VBP
cord-328189-jpkxjn6e	76	5	highly	highly	RB
cord-328189-jpkxjn6e	76	6	flexible	flexible	JJ
cord-328189-jpkxjn6e	76	7	in	in	IN
cord-328189-jpkxjn6e	76	8	the	the	DT
cord-328189-jpkxjn6e	76	9	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	76	10	RBD	RBD	NNP
cord-328189-jpkxjn6e	76	11	(	(	-LRB-
cord-328189-jpkxjn6e	76	12	Fig	Fig	NNP
cord-328189-jpkxjn6e	76	13	.	.	.
cord-328189-jpkxjn6e	76	14	3	3	CD
cord-328189-jpkxjn6e	76	15	,	,	,
cord-328189-jpkxjn6e	76	16	A	a	NN
cord-328189-jpkxjn6e	76	17	and	and	CC
cord-328189-jpkxjn6e	76	18	D	D	NNP
cord-328189-jpkxjn6e	76	19	)	)	-RRB-
cord-328189-jpkxjn6e	76	20	.	.	.
cord-328189-jpkxjn6e	77	1	While	while	IN
cord-328189-jpkxjn6e	77	2	loop1	loop1	NN
cord-328189-jpkxjn6e	77	3	is	be	VBZ
cord-328189-jpkxjn6e	77	4	also	also	RB
cord-328189-jpkxjn6e	77	5	fluctuating	fluctuate	VBG
cord-328189-jpkxjn6e	77	6	in	in	IN
cord-328189-jpkxjn6e	77	7	the	the	DT
cord-328189-jpkxjn6e	77	8	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	77	9	RBD	RBD	NNP
cord-328189-jpkxjn6e	77	10	,	,	,
cord-328189-jpkxjn6e	77	11	albeit	albeit	RB
cord-328189-jpkxjn6e	77	12	much	much	RB
cord-328189-jpkxjn6e	77	13	less	less	JJR
cord-328189-jpkxjn6e	77	14	,	,	,
cord-328189-jpkxjn6e	77	15	loop2	loop2	NNP
cord-328189-jpkxjn6e	77	16	remains	remain	VBZ
cord-328189-jpkxjn6e	77	17	relatively	relatively	RB
cord-328189-jpkxjn6e	77	18	rigid	rigid	JJ
cord-328189-jpkxjn6e	77	19	in	in	IN
cord-328189-jpkxjn6e	77	20	the	the	DT
cord-328189-jpkxjn6e	77	21	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	77	22	RBD	RBD	NNP
cord-328189-jpkxjn6e	77	23	.	.	.
cord-328189-jpkxjn6e	78	1	In	in	IN
cord-328189-jpkxjn6e	78	2	addition	addition	NN
cord-328189-jpkxjn6e	78	3	,	,	,
cord-328189-jpkxjn6e	78	4	we	-PRON-	PRP
cord-328189-jpkxjn6e	78	5	find	find	VBP
cord-328189-jpkxjn6e	78	6	that	that	IN
cord-328189-jpkxjn6e	78	7	in	in	IN
cord-328189-jpkxjn6e	78	8	the	the	DT
cord-328189-jpkxjn6e	78	9	COVID-19-RBD	covid-19-rbd	NN
cord-328189-jpkxjn6e	78	10	,	,	,
cord-328189-jpkxjn6e	78	11	a	a	DT
cord-328189-jpkxjn6e	78	12	region	region	NN
cord-328189-jpkxjn6e	78	13	centered	center	VBN
cord-328189-jpkxjn6e	78	14	around	around	RB
cord-328189-jpkxjn6e	78	15	K417	K417	NNS
cord-328189-jpkxjn6e	78	16	leads	lead	VBZ
cord-328189-jpkxjn6e	78	17	to	to	IN
cord-328189-jpkxjn6e	78	18	further	further	JJ
cord-328189-jpkxjn6e	78	19	stability	stability	NN
cord-328189-jpkxjn6e	78	20	relative	relative	JJ
cord-328189-jpkxjn6e	78	21	to	to	IN
cord-328189-jpkxjn6e	78	22	the	the	DT
cord-328189-jpkxjn6e	78	23	corresponding	correspond	VBG
cord-328189-jpkxjn6e	78	24	region	region	NN
cord-328189-jpkxjn6e	78	25	in	in	IN
cord-328189-jpkxjn6e	78	26	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	78	27	.	.	.
cord-328189-jpkxjn6e	79	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	79	2	attribute	attribute	VBP
cord-328189-jpkxjn6e	79	3	this	this	DT
cord-328189-jpkxjn6e	79	4	difference	difference	NN
cord-328189-jpkxjn6e	79	5	to	to	IN
cord-328189-jpkxjn6e	79	6	the	the	DT
cord-328189-jpkxjn6e	79	7	unique	unique	JJ
cord-328189-jpkxjn6e	79	8	interaction	interaction	NN
cord-328189-jpkxjn6e	79	9	of	of	IN
cord-328189-jpkxjn6e	79	10	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	79	11	at	at	IN
cord-328189-jpkxjn6e	79	12	position	position	NN
cord-328189-jpkxjn6e	79	13	K417	K417	NFP
cord-328189-jpkxjn6e	79	14	with	with	IN
cord-328189-jpkxjn6e	79	15	the	the	DT
cord-328189-jpkxjn6e	79	16	middle	middle	NN
cord-328189-jpkxjn6e	79	17	of	of	IN
cord-328189-jpkxjn6e	79	18	the	the	DT
cord-328189-jpkxjn6e	79	19	N	N	NNP
cord-328189-jpkxjn6e	79	20	-	-	HYPH
cord-328189-jpkxjn6e	79	21	terminal	terminal	NN
cord-328189-jpkxjn6e	79	22	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	79	23	helix	helix	NN
cord-328189-jpkxjn6e	79	24	,	,	,
cord-328189-jpkxjn6e	79	25	thus	thus	RB
cord-328189-jpkxjn6e	79	26	serving	serve	VBG
cord-328189-jpkxjn6e	79	27	as	as	IN
cord-328189-jpkxjn6e	79	28	an	an	DT
cord-328189-jpkxjn6e	79	29	anchor	anchor	NN
cord-328189-jpkxjn6e	79	30	site	site	NN
cord-328189-jpkxjn6e	79	31	to	to	IN
cord-328189-jpkxjn6e	79	32	the	the	DT
cord-328189-jpkxjn6e	79	33	receptor	receptor	NN
cord-328189-jpkxjn6e	80	1	(	(	-LRB-
cord-328189-jpkxjn6e	80	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	80	3	.	.	.
cord-328189-jpkxjn6e	80	4	2C	2C	NNP
cord-328189-jpkxjn6e	80	5	and	and	CC
cord-328189-jpkxjn6e	80	6	Fig	Fig	NNP
cord-328189-jpkxjn6e	80	7	.	.	.
cord-328189-jpkxjn6e	80	8	3A	3A	NNP
cord-328189-jpkxjn6e	80	9	)	)	-RRB-
cord-328189-jpkxjn6e	80	10	.	.	.
cord-328189-jpkxjn6e	81	1	The	the	DT
cord-328189-jpkxjn6e	81	2	contribution	contribution	NN
cord-328189-jpkxjn6e	81	3	of	of	IN
cord-328189-jpkxjn6e	81	4	K417	k417	CD
cord-328189-jpkxjn6e	81	5	to	to	IN
cord-328189-jpkxjn6e	81	6	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	81	7	binding	binding	NN
cord-328189-jpkxjn6e	81	8	is	be	VBZ
cord-328189-jpkxjn6e	81	9	observed	observe	VBN
cord-328189-jpkxjn6e	81	10	in	in	IN
cord-328189-jpkxjn6e	81	11	a	a	DT
cord-328189-jpkxjn6e	81	12	recent	recent	JJ
cord-328189-jpkxjn6e	81	13	cryoEM	cryoEM	NNP
cord-328189-jpkxjn6e	81	14	structure	structure	NN
cord-328189-jpkxjn6e	81	15	of	of	IN
cord-328189-jpkxjn6e	81	16	the	the	DT
cord-328189-jpkxjn6e	81	17	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	81	18	spike	spike	NN
cord-328189-jpkxjn6e	81	19	protein	protein	NN
cord-328189-jpkxjn6e	81	20	bound	bind	VBN
cord-328189-jpkxjn6e	81	21	to	to	IN
cord-328189-jpkxjn6e	81	22	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	81	23	(	(	-LRB-
cord-328189-jpkxjn6e	81	24	17	17	CD
cord-328189-jpkxjn6e	81	25	)	)	-RRB-
cord-328189-jpkxjn6e	81	26	.	.	.
cord-328189-jpkxjn6e	82	1	Overall	overall	RB
cord-328189-jpkxjn6e	82	2	,	,	,
cord-328189-jpkxjn6e	82	3	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	82	4	is	be	VBZ
cord-328189-jpkxjn6e	82	5	more	more	RBR
cord-328189-jpkxjn6e	82	6	rigid	rigid	JJ
cord-328189-jpkxjn6e	82	7	compared	compare	VBN
cord-328189-jpkxjn6e	82	8	to	to	IN
cord-328189-jpkxjn6e	82	9	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	82	10	(	(	-LRB-
cord-328189-jpkxjn6e	82	11	Fig	fig	NN
cord-328189-jpkxjn6e	82	12	.	.	.
cord-328189-jpkxjn6e	83	1	3	3	LS
cord-328189-jpkxjn6e	83	2	,	,	,
cord-328189-jpkxjn6e	83	3	A	a	NN
cord-328189-jpkxjn6e	83	4	and	and	CC
cord-328189-jpkxjn6e	83	5	D	D	NNP
cord-328189-jpkxjn6e	83	6	)	)	-RRB-
cord-328189-jpkxjn6e	83	7	.	.	.
cord-328189-jpkxjn6e	84	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	84	2	investigate	investigate	VBP
cord-328189-jpkxjn6e	84	3	the	the	DT
cord-328189-jpkxjn6e	84	4	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	84	5	of	of	IN
cord-328189-jpkxjn6e	84	6	a	a	DT
cord-328189-jpkxjn6e	84	7	designed	design	VBN
cord-328189-jpkxjn6e	84	8	SARS	SARS	NNP
cord-328189-jpkxjn6e	84	9	(	(	-LRB-
cord-328189-jpkxjn6e	84	10	SARS	SARS	NNP
cord-328189-jpkxjn6e	84	11	-	-	HYPH
cord-328189-jpkxjn6e	84	12	des	des	NNP
cord-328189-jpkxjn6e	84	13	)	)	-RRB-
cord-328189-jpkxjn6e	85	1	variant	variant	NNP
cord-328189-jpkxjn6e	85	2	(	(	-LRB-
cord-328189-jpkxjn6e	85	3	11	11	CD
cord-328189-jpkxjn6e	85	4	)	)	-RRB-
cord-328189-jpkxjn6e	85	5	Table	table	NN
cord-328189-jpkxjn6e	85	6	S1	S1	NNP
cord-328189-jpkxjn6e	85	7	)	)	-RRB-
cord-328189-jpkxjn6e	85	8	.	.	.
cord-328189-jpkxjn6e	86	1	The	the	DT
cord-328189-jpkxjn6e	86	2	L486F	L486F	NNP
cord-328189-jpkxjn6e	86	3	mutation	mutation	NN
cord-328189-jpkxjn6e	86	4	is	be	VBZ
cord-328189-jpkxjn6e	86	5	of	of	IN
cord-328189-jpkxjn6e	86	6	special	special	JJ
cord-328189-jpkxjn6e	86	7	interest	interest	NN
cord-328189-jpkxjn6e	86	8	for	for	IN
cord-328189-jpkxjn6e	86	9	the	the	DT
cord-328189-jpkxjn6e	86	10	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	86	11	RBD	RBD	NNP
cord-328189-jpkxjn6e	86	12	as	as	RB
cord-328189-jpkxjn6e	86	13	well	well	RB
cord-328189-jpkxjn6e	86	14	because	because	IN
cord-328189-jpkxjn6e	86	15	it	-PRON-	PRP
cord-328189-jpkxjn6e	86	16	has	have	VBZ
cord-328189-jpkxjn6e	86	17	this	this	DT
cord-328189-jpkxjn6e	86	18	same	same	JJ
cord-328189-jpkxjn6e	86	19	substitution	substitution	NN
cord-328189-jpkxjn6e	86	20	.	.	.
cord-328189-jpkxjn6e	87	1	Our	-PRON-	PRP$
cord-328189-jpkxjn6e	87	2	MD	MD	NNP
cord-328189-jpkxjn6e	87	3	simulation	simulation	NN
cord-328189-jpkxjn6e	87	4	analysis	analysis	NN
cord-328189-jpkxjn6e	87	5	reveals	reveal	VBZ
cord-328189-jpkxjn6e	87	6	that	that	IN
cord-328189-jpkxjn6e	87	7	the	the	DT
cord-328189-jpkxjn6e	87	8	SARS	SARS	NNP
cord-328189-jpkxjn6e	87	9	-	-	HYPH
cord-328189-jpkxjn6e	87	10	des	des	NNP
cord-328189-jpkxjn6e	87	11	has	have	VBZ
cord-328189-jpkxjn6e	87	12	a	a	DT
cord-328189-jpkxjn6e	87	13	substantially	substantially	RB
cord-328189-jpkxjn6e	87	14	lower	low	JJR
cord-328189-jpkxjn6e	87	15	interaction	interaction	NN
cord-328189-jpkxjn6e	87	16	scores	score	NNS
cord-328189-jpkxjn6e	87	17	with	with	IN
cord-328189-jpkxjn6e	87	18	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	87	19	(	(	-LRB-
cord-328189-jpkxjn6e	87	20	median	median	NN
cord-328189-jpkxjn6e	87	21	of	of	IN
cord-328189-jpkxjn6e	87	22	-2199.2	-2199.2	,
cord-328189-jpkxjn6e	87	23	,	,	,
cord-328189-jpkxjn6e	87	24	Fig	Fig	NNP
cord-328189-jpkxjn6e	87	25	.	.	.
cord-328189-jpkxjn6e	87	26	S2	S2	NNP
cord-328189-jpkxjn6e	87	27	)	)	-RRB-
cord-328189-jpkxjn6e	87	28	,	,	,
cord-328189-jpkxjn6e	87	29	as	as	IN
cord-328189-jpkxjn6e	87	30	expected	expect	VBN
cord-328189-jpkxjn6e	87	31	for	for	IN
cord-328189-jpkxjn6e	87	32	an	an	DT
cord-328189-jpkxjn6e	87	33	optimized	optimize	VBN
cord-328189-jpkxjn6e	87	34	human	human	NN
cord-328189-jpkxjn6e	87	35	ACE2-binding	ace2-binde	VBG
cord-328189-jpkxjn6e	87	36	RBD	RBD	NNP
cord-328189-jpkxjn6e	87	37	design	design	NN
cord-328189-jpkxjn6e	87	38	.	.	.
cord-328189-jpkxjn6e	88	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	88	2	observed	observe	VBD
cord-328189-jpkxjn6e	88	3	that	that	IN
cord-328189-jpkxjn6e	88	4	these	these	DT
cord-328189-jpkxjn6e	88	5	two	two	CD
cord-328189-jpkxjn6e	88	6	mutations	mutation	NNS
cord-328189-jpkxjn6e	88	7	not	not	RB
cord-328189-jpkxjn6e	88	8	only	only	RB
cord-328189-jpkxjn6e	88	9	enhance	enhance	VBP
cord-328189-jpkxjn6e	88	10	the	the	DT
cord-328189-jpkxjn6e	88	11	binding	bind	VBG
cord-328189-jpkxjn6e	88	12	affinity	affinity	NN
cord-328189-jpkxjn6e	88	13	to	to	IN
cord-328189-jpkxjn6e	88	14	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	88	15	,	,	,
cord-328189-jpkxjn6e	88	16	but	but	CC
cord-328189-jpkxjn6e	88	17	also	also	RB
cord-328189-jpkxjn6e	88	18	lead	lead	VBP
cord-328189-jpkxjn6e	88	19	to	to	IN
cord-328189-jpkxjn6e	88	20	a	a	DT
cord-328189-jpkxjn6e	88	21	substantial	substantial	JJ
cord-328189-jpkxjn6e	88	22	stabilization	stabilization	NN
cord-328189-jpkxjn6e	88	23	of	of	IN
cord-328189-jpkxjn6e	88	24	the	the	DT
cord-328189-jpkxjn6e	88	25	interaction	interaction	NN
cord-328189-jpkxjn6e	88	26	interface	interface	NN
cord-328189-jpkxjn6e	88	27	.	.	.
cord-328189-jpkxjn6e	89	1	The	the	DT
cord-328189-jpkxjn6e	89	2	fluctuation	fluctuation	NN
cord-328189-jpkxjn6e	89	3	signatures	signature	VBZ
cord-328189-jpkxjn6e	89	4	along	along	IN
cord-328189-jpkxjn6e	89	5	the	the	DT
cord-328189-jpkxjn6e	89	6	RBD	RBD	NNP
cord-328189-jpkxjn6e	89	7	of	of	IN
cord-328189-jpkxjn6e	89	8	SARS	SARS	NNP
cord-328189-jpkxjn6e	89	9	-	-	HYPH
cord-328189-jpkxjn6e	89	10	des	des	NNP
cord-328189-jpkxjn6e	89	11	are	be	VBP
cord-328189-jpkxjn6e	89	12	surprisingly	surprisingly	RB
cord-328189-jpkxjn6e	89	13	similar	similar	JJ
cord-328189-jpkxjn6e	89	14	to	to	IN
cord-328189-jpkxjn6e	89	15	those	those	DT
cord-328189-jpkxjn6e	89	16	recorded	record	VBN
cord-328189-jpkxjn6e	89	17	for	for	IN
cord-328189-jpkxjn6e	89	18	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	89	19	(	(	-LRB-
cord-328189-jpkxjn6e	89	20	Fig	Fig	NNP
cord-328189-jpkxjn6e	89	21	.	.	.
cord-328189-jpkxjn6e	90	1	3	3	LS
cord-328189-jpkxjn6e	90	2	,	,	,
cord-328189-jpkxjn6e	90	3	B	b	NN
cord-328189-jpkxjn6e	90	4	and	and	CC
cord-328189-jpkxjn6e	90	5	C	C	NNP
cord-328189-jpkxjn6e	90	6	)	)	-RRB-
cord-328189-jpkxjn6e	90	7	.	.	.
cord-328189-jpkxjn6e	91	1	Thus	thus	RB
cord-328189-jpkxjn6e	91	2	,	,	,
cord-328189-jpkxjn6e	91	3	the	the	DT
cord-328189-jpkxjn6e	91	4	switch	switch	NN
cord-328189-jpkxjn6e	91	5	from	from	IN
cord-328189-jpkxjn6e	91	6	a	a	DT
cord-328189-jpkxjn6e	91	7	flexible	flexible	JJ
cord-328189-jpkxjn6e	91	8	binding	binding	NN
cord-328189-jpkxjn6e	91	9	mode	mode	NN
cord-328189-jpkxjn6e	91	10	(	(	-LRB-
cord-328189-jpkxjn6e	91	11	for	for	IN
cord-328189-jpkxjn6e	91	12	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	91	13	)	)	-RRB-
cord-328189-jpkxjn6e	91	14	to	to	IN
cord-328189-jpkxjn6e	91	15	a	a	DT
cord-328189-jpkxjn6e	91	16	stable	stable	JJ
cord-328189-jpkxjn6e	91	17	one	one	CD
cord-328189-jpkxjn6e	91	18	(	(	-LRB-
cord-328189-jpkxjn6e	91	19	COVID-19	covid-19	VB
cord-328189-jpkxjn6e	91	20	and	and	CC
cord-328189-jpkxjn6e	91	21	SARSdes	sarsde	NNS
cord-328189-jpkxjn6e	91	22	,	,	,
cord-328189-jpkxjn6e	91	23	Fig	Fig	NNP
cord-328189-jpkxjn6e	91	24	.	.	.
cord-328189-jpkxjn6e	91	25	3B	3B	NNP
cord-328189-jpkxjn6e	91	26	)	)	-RRB-
cord-328189-jpkxjn6e	91	27	highlights	highlight	VBZ
cord-328189-jpkxjn6e	91	28	the	the	DT
cord-328189-jpkxjn6e	91	29	remarkable	remarkable	JJ
cord-328189-jpkxjn6e	91	30	capacity	capacity	NN
cord-328189-jpkxjn6e	91	31	of	of	IN
cord-328189-jpkxjn6e	91	32	the	the	DT
cord-328189-jpkxjn6e	91	33	RBD	RBD	NNP
cord-328189-jpkxjn6e	91	34	to	to	TO
cord-328189-jpkxjn6e	91	35	adopt	adopt	VB
cord-328189-jpkxjn6e	91	36	alternative	alternative	JJ
cord-328189-jpkxjn6e	91	37	receptor	receptor	NN
cord-328189-jpkxjn6e	91	38	binding	bind	VBG
cord-328189-jpkxjn6e	91	39	strategies	strategy	NNS
cord-328189-jpkxjn6e	91	40	driven	drive	VBN
cord-328189-jpkxjn6e	91	41	by	by	IN
cord-328189-jpkxjn6e	91	42	a	a	DT
cord-328189-jpkxjn6e	91	43	minimal	minimal	JJ
cord-328189-jpkxjn6e	91	44	number	number	NN
cord-328189-jpkxjn6e	91	45	of	of	IN
cord-328189-jpkxjn6e	91	46	amino	amino	NN
cord-328189-jpkxjn6e	91	47	acid	acid	NN
cord-328189-jpkxjn6e	91	48	substitutions	substitution	NNS
cord-328189-jpkxjn6e	91	49	.	.	.
cord-328189-jpkxjn6e	92	1	This	this	DT
cord-328189-jpkxjn6e	92	2	analysis	analysis	NN
cord-328189-jpkxjn6e	92	3	reveals	reveal	VBZ
cord-328189-jpkxjn6e	92	4	the	the	DT
cord-328189-jpkxjn6e	92	5	critical	critical	JJ
cord-328189-jpkxjn6e	92	6	role	role	NN
cord-328189-jpkxjn6e	92	7	of	of	IN
cord-328189-jpkxjn6e	92	8	L486F	L486F	NNP
cord-328189-jpkxjn6e	92	9	(	(	-LRB-
cord-328189-jpkxjn6e	92	10	SARS	SARS	NNP
cord-328189-jpkxjn6e	92	11	-	-	HYPH
cord-328189-jpkxjn6e	92	12	des	des	NNP
cord-328189-jpkxjn6e	92	13	residue	residue	NN
cord-328189-jpkxjn6e	92	14	F472	F472	NNP
cord-328189-jpkxjn6e	92	15	)	)	-RRB-
cord-328189-jpkxjn6e	92	16	for	for	IN
cord-328189-jpkxjn6e	92	17	stabilizing	stabilize	VBG
cord-328189-jpkxjn6e	92	18	the	the	DT
cord-328189-jpkxjn6e	92	19	COVID-19-ACE2	covid-19-ace2	CD
cord-328189-jpkxjn6e	92	20	interface	interface	NN
cord-328189-jpkxjn6e	92	21	and	and	CC
cord-328189-jpkxjn6e	92	22	a	a	DT
cord-328189-jpkxjn6e	92	23	reduction	reduction	NN
cord-328189-jpkxjn6e	92	24	in	in	IN
cord-328189-jpkxjn6e	92	25	the	the	DT
cord-328189-jpkxjn6e	92	26	number	number	NN
cord-328189-jpkxjn6e	92	27	of	of	IN
cord-328189-jpkxjn6e	92	28	states	state	NNS
cord-328189-jpkxjn6e	92	29	of	of	IN
cord-328189-jpkxjn6e	92	30	the	the	DT
cord-328189-jpkxjn6e	92	31	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	92	32	spike	spike	NN
cord-328189-jpkxjn6e	92	33	protein	protein	NN
cord-328189-jpkxjn6e	92	34	bound	bind	VBN
cord-328189-jpkxjn6e	92	35	to	to	IN
cord-328189-jpkxjn6e	92	36	an	an	DT
cord-328189-jpkxjn6e	92	37	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	92	38	receptor	receptor	NN
cord-328189-jpkxjn6e	92	39	.	.	.
cord-328189-jpkxjn6e	93	1	Experimental	experimental	JJ
cord-328189-jpkxjn6e	93	2	affinity	affinity	NN
cord-328189-jpkxjn6e	93	3	measurements	measurement	NNS
cord-328189-jpkxjn6e	93	4	(	(	-LRB-
cord-328189-jpkxjn6e	93	5	e.g.	e.g.	RB
cord-328189-jpkxjn6e	93	6	surface	surface	NN
cord-328189-jpkxjn6e	93	7	plasmon	plasmon	JJ
cord-328189-jpkxjn6e	93	8	resonance	resonance	NN
cord-328189-jpkxjn6e	93	9	,	,	,
cord-328189-jpkxjn6e	93	10	SPR	SPR	NNP
cord-328189-jpkxjn6e	93	11	)	)	-RRB-
cord-328189-jpkxjn6e	93	12	confirm	confirm	VBP
cord-328189-jpkxjn6e	93	13	the	the	DT
cord-328189-jpkxjn6e	93	14	high	high	JJ
cord-328189-jpkxjn6e	93	15	affinity	affinity	NN
cord-328189-jpkxjn6e	93	16	of	of	IN
cord-328189-jpkxjn6e	93	17	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	93	18	RBD	RBD	NNP
cord-328189-jpkxjn6e	93	19	-	-	HYPH
cord-328189-jpkxjn6e	93	20	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	93	21	binding	binding	NN
cord-328189-jpkxjn6e	93	22	,	,	,
cord-328189-jpkxjn6e	93	23	with	with	IN
cord-328189-jpkxjn6e	93	24	an	an	DT
cord-328189-jpkxjn6e	93	25	equilibrium	equilibrium	NN
cord-328189-jpkxjn6e	93	26	dissociation	dissociation	NN
cord-328189-jpkxjn6e	93	27	constant	constant	NN
cord-328189-jpkxjn6e	93	28	(	(	-LRB-
cord-328189-jpkxjn6e	93	29	KD	KD	NNP
cord-328189-jpkxjn6e	93	30	)	)	-RRB-
cord-328189-jpkxjn6e	93	31	of	of	IN
cord-328189-jpkxjn6e	93	32	~15	~15	JJS
cord-328189-jpkxjn6e	93	33	mM	mm	CD
cord-328189-jpkxjn6e	93	34	(	(	-LRB-
cord-328189-jpkxjn6e	93	35	18	18	CD
cord-328189-jpkxjn6e	93	36	)	)	-RRB-
cord-328189-jpkxjn6e	94	1	(	(	-LRB-
cord-328189-jpkxjn6e	94	2	19	19	CD
cord-328189-jpkxjn6e	94	3	)	)	-RRB-
cord-328189-jpkxjn6e	94	4	(	(	-LRB-
cord-328189-jpkxjn6e	94	5	20	20	CD
cord-328189-jpkxjn6e	94	6	)	)	-RRB-
cord-328189-jpkxjn6e	94	7	(	(	-LRB-
cord-328189-jpkxjn6e	94	8	21	21	CD
cord-328189-jpkxjn6e	94	9	)	)	-RRB-
cord-328189-jpkxjn6e	94	10	,	,	,
cord-328189-jpkxjn6e	94	11	similar	similar	JJ
cord-328189-jpkxjn6e	94	12	to	to	IN
cord-328189-jpkxjn6e	94	13	the	the	DT
cord-328189-jpkxjn6e	94	14	binding	bind	VBG
cord-328189-jpkxjn6e	94	15	affinity	affinity	NN
cord-328189-jpkxjn6e	94	16	of	of	IN
cord-328189-jpkxjn6e	94	17	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	94	18	and	and	CC
cord-328189-jpkxjn6e	94	19	the	the	DT
cord-328189-jpkxjn6e	94	20	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	94	21	RBD	RBD	NNP
cord-328189-jpkxjn6e	94	22	(	(	-LRB-
cord-328189-jpkxjn6e	94	23	22	22	CD
cord-328189-jpkxjn6e	94	24	,	,	,
cord-328189-jpkxjn6e	94	25	23	23	CD
cord-328189-jpkxjn6e	94	26	)	)	-RRB-
cord-328189-jpkxjn6e	94	27	.	.	.
cord-328189-jpkxjn6e	95	1	Our	-PRON-	PRP$
cord-328189-jpkxjn6e	95	2	MD	MD	NNP
cord-328189-jpkxjn6e	95	3	based	base	VBN
cord-328189-jpkxjn6e	95	4	calculation	calculation	NN
cord-328189-jpkxjn6e	95	5	is	be	VBZ
cord-328189-jpkxjn6e	95	6	consistent	consistent	JJ
cord-328189-jpkxjn6e	95	7	with	with	IN
cord-328189-jpkxjn6e	95	8	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	95	9	displaying	display	VBG
cord-328189-jpkxjn6e	95	10	a	a	DT
cord-328189-jpkxjn6e	95	11	similar	similar	JJ
cord-328189-jpkxjn6e	95	12	but	but	CC
cord-328189-jpkxjn6e	95	13	slightly	slightly	RB
cord-328189-jpkxjn6e	95	14	higher	high	JJR
cord-328189-jpkxjn6e	95	15	affinity	affinity	NN
cord-328189-jpkxjn6e	95	16	relative	relative	NN
cord-328189-jpkxjn6e	95	17	to	to	IN
cord-328189-jpkxjn6e	95	18	COVID-19	covid-19	VB
cord-328189-jpkxjn6e	96	1	(	(	-LRB-
cord-328189-jpkxjn6e	96	2	Fig	Fig	NNP
cord-328189-jpkxjn6e	96	3	.	.	.
cord-328189-jpkxjn6e	96	4	1A	1a	NN
cord-328189-jpkxjn6e	96	5	,	,	,
cord-328189-jpkxjn6e	96	6	Fig	Fig	NNP
cord-328189-jpkxjn6e	96	7	.	.	.
cord-328189-jpkxjn6e	97	1	S2	S2	NNP
cord-328189-jpkxjn6e	97	2	and	and	CC
cord-328189-jpkxjn6e	97	3	Table	Table	NNP
cord-328189-jpkxjn6e	97	4	S2	S2	NNP
cord-328189-jpkxjn6e	97	5	)	)	-RRB-
cord-328189-jpkxjn6e	97	6	.	.	.
cord-328189-jpkxjn6e	98	1	Binding	bind	VBG
cord-328189-jpkxjn6e	98	2	affinity	affinity	NN
cord-328189-jpkxjn6e	98	3	is	be	VBZ
cord-328189-jpkxjn6e	98	4	achieved	achieve	VBN
cord-328189-jpkxjn6e	98	5	through	through	IN
cord-328189-jpkxjn6e	98	6	a	a	DT
cord-328189-jpkxjn6e	98	7	combination	combination	NN
cord-328189-jpkxjn6e	98	8	of	of	IN
cord-328189-jpkxjn6e	98	9	interface	interface	NN
cord-328189-jpkxjn6e	98	10	contact	contact	NN
cord-328189-jpkxjn6e	98	11	optimization	optimization	NN
cord-328189-jpkxjn6e	98	12	and	and	CC
cord-328189-jpkxjn6e	98	13	protein	protein	NN
cord-328189-jpkxjn6e	98	14	stability	stability	NN
cord-328189-jpkxjn6e	98	15	(	(	-LRB-
cord-328189-jpkxjn6e	98	16	Fig	Fig	NNP
cord-328189-jpkxjn6e	98	17	.	.	.
cord-328189-jpkxjn6e	98	18	3E	3E	NNP
cord-328189-jpkxjn6e	98	19	)	)	-RRB-
cord-328189-jpkxjn6e	98	20	.	.	.
cord-328189-jpkxjn6e	99	1	While	while	IN
cord-328189-jpkxjn6e	99	2	the	the	DT
cord-328189-jpkxjn6e	99	3	RBD	RBD	NNP
cord-328189-jpkxjn6e	99	4	-	-	HYPH
cord-328189-jpkxjn6e	99	5	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	99	6	complex	complex	NN
cord-328189-jpkxjn6e	99	7	can	can	MD
cord-328189-jpkxjn6e	99	8	be	be	VB
cord-328189-jpkxjn6e	99	9	resolved	resolve	VBN
cord-328189-jpkxjn6e	99	10	at	at	IN
cord-328189-jpkxjn6e	99	11	high	high	JJ
cord-328189-jpkxjn6e	99	12	-	-	HYPH
cord-328189-jpkxjn6e	99	13	resolution	resolution	NN
cord-328189-jpkxjn6e	99	14	by	by	IN
cord-328189-jpkxjn6e	99	15	cryo	cryo	NN
cord-328189-jpkxjn6e	99	16	-	-	HYPH
cord-328189-jpkxjn6e	99	17	EM	EM	NNP
cord-328189-jpkxjn6e	99	18	(	(	-LRB-
cord-328189-jpkxjn6e	99	19	17	17	CD
cord-328189-jpkxjn6e	99	20	,	,	,
cord-328189-jpkxjn6e	99	21	23	23	CD
cord-328189-jpkxjn6e	99	22	)	)	-RRB-
cord-328189-jpkxjn6e	99	23	,	,	,
cord-328189-jpkxjn6e	99	24	MD	MD	NNP
cord-328189-jpkxjn6e	99	25	simulations	simulation	NNS
cord-328189-jpkxjn6e	99	26	provide	provide	VBP
cord-328189-jpkxjn6e	99	27	orthogonal	orthogonal	JJ
cord-328189-jpkxjn6e	99	28	information	information	NN
cord-328189-jpkxjn6e	99	29	about	about	IN
cord-328189-jpkxjn6e	99	30	the	the	DT
cord-328189-jpkxjn6e	99	31	interaction	interaction	NN
cord-328189-jpkxjn6e	99	32	dynamics	dynamic	NNS
cord-328189-jpkxjn6e	99	33	on	on	IN
cord-328189-jpkxjn6e	99	34	a	a	DT
cord-328189-jpkxjn6e	99	35	nanosecond	nanosecond	NN
cord-328189-jpkxjn6e	99	36	timescale	timescale	NN
cord-328189-jpkxjn6e	99	37	.	.	.
cord-328189-jpkxjn6e	100	1	In	in	IN
cord-328189-jpkxjn6e	100	2	the	the	DT
cord-328189-jpkxjn6e	100	3	case	case	NN
cord-328189-jpkxjn6e	100	4	of	of	IN
cord-328189-jpkxjn6e	100	5	CoVs	CoVs	NNP
cord-328189-jpkxjn6e	100	6	,	,	,
cord-328189-jpkxjn6e	100	7	MD	MD	NNP
cord-328189-jpkxjn6e	100	8	simulations	simulation	NNS
cord-328189-jpkxjn6e	100	9	reveal	reveal	VBP
cord-328189-jpkxjn6e	100	10	an	an	DT
cord-328189-jpkxjn6e	100	11	exceptional	exceptional	JJ
cord-328189-jpkxjn6e	100	12	versatility	versatility	NN
cord-328189-jpkxjn6e	100	13	of	of	IN
cord-328189-jpkxjn6e	100	14	viral	viral	JJ
cord-328189-jpkxjn6e	100	15	receptor	receptor	NN
cord-328189-jpkxjn6e	100	16	binding	bind	VBG
cord-328189-jpkxjn6e	100	17	strategies	strategy	NNS
cord-328189-jpkxjn6e	100	18	(	(	-LRB-
cord-328189-jpkxjn6e	100	19	Fig	Fig	NNP
cord-328189-jpkxjn6e	100	20	.	.	.
cord-328189-jpkxjn6e	100	21	3E	3E	NNP
cord-328189-jpkxjn6e	100	22	)	)	-RRB-
cord-328189-jpkxjn6e	100	23	.	.	.
cord-328189-jpkxjn6e	101	1	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	101	2	adopted	adopt	VBD
cord-328189-jpkxjn6e	101	3	a	a	DT
cord-328189-jpkxjn6e	101	4	different	different	JJ
cord-328189-jpkxjn6e	101	5	strategy	strategy	NN
cord-328189-jpkxjn6e	101	6	for	for	IN
cord-328189-jpkxjn6e	101	7	achieving	achieve	VBG
cord-328189-jpkxjn6e	101	8	comparable	comparable	JJ
cord-328189-jpkxjn6e	101	9	affinity	affinity	NN
cord-328189-jpkxjn6e	101	10	to	to	IN
cord-328189-jpkxjn6e	101	11	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	101	12	:	:	:
cord-328189-jpkxjn6e	101	13	the	the	DT
cord-328189-jpkxjn6e	101	14	interface	interface	NN
cord-328189-jpkxjn6e	101	15	of	of	IN
cord-328189-jpkxjn6e	101	16	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	101	17	is	be	VBZ
cord-328189-jpkxjn6e	101	18	significantly	significantly	RB
cord-328189-jpkxjn6e	101	19	larger	large	JJR
cord-328189-jpkxjn6e	101	20	than	than	IN
cord-328189-jpkxjn6e	101	21	that	that	DT
cord-328189-jpkxjn6e	101	22	of	of	IN
cord-328189-jpkxjn6e	101	23	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	101	24	(	(	-LRB-
cord-328189-jpkxjn6e	101	25	1204Å	1204å	CD
cord-328189-jpkxjn6e	101	26	vs.	vs.	IN
cord-328189-jpkxjn6e	101	27	998Å	998å	CD
cord-328189-jpkxjn6e	101	28	)	)	-RRB-
cord-328189-jpkxjn6e	101	29	with	with	IN
cord-328189-jpkxjn6e	101	30	a	a	DT
cord-328189-jpkxjn6e	101	31	remarkable	remarkable	JJ
cord-328189-jpkxjn6e	101	32	number	number	NN
cord-328189-jpkxjn6e	101	33	of	of	IN
cord-328189-jpkxjn6e	101	34	interacting	interact	VBG
cord-328189-jpkxjn6e	101	35	residues	residue	NNS
cord-328189-jpkxjn6e	101	36	(	(	-LRB-
cord-328189-jpkxjn6e	101	37	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	101	38	:	:	:
cord-328189-jpkxjn6e	101	39	30	30	CD
cord-328189-jpkxjn6e	101	40	vs.	vs.	IN
cord-328189-jpkxjn6e	101	41	24	24	CD
cord-328189-jpkxjn6e	101	42	,	,	,
cord-328189-jpkxjn6e	101	43	Fig	Fig	NNP
cord-328189-jpkxjn6e	101	44	.	.	NNP
cord-328189-jpkxjn6e	101	45	1C	1C	NNP
cord-328189-jpkxjn6e	101	46	)	)	-RRB-
cord-328189-jpkxjn6e	101	47	.	.	.
cord-328189-jpkxjn6e	102	1	In	in	IN
cord-328189-jpkxjn6e	102	2	contrast	contrast	NN
cord-328189-jpkxjn6e	102	3	,	,	,
cord-328189-jpkxjn6e	102	4	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	102	5	is	be	VBZ
cord-328189-jpkxjn6e	102	6	more	more	RBR
cord-328189-jpkxjn6e	102	7	flexible	flexible	JJ
cord-328189-jpkxjn6e	102	8	in	in	IN
cord-328189-jpkxjn6e	102	9	its	-PRON-	PRP$
cord-328189-jpkxjn6e	102	10	interaction	interaction	NN
cord-328189-jpkxjn6e	102	11	with	with	IN
cord-328189-jpkxjn6e	102	12	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	102	13	,	,	,
cord-328189-jpkxjn6e	102	14	interacting	interact	VBG
cord-328189-jpkxjn6e	102	15	through	through	IN
cord-328189-jpkxjn6e	102	16	fewer	few	JJR
cord-328189-jpkxjn6e	102	17	contacts	contact	NNS
cord-328189-jpkxjn6e	102	18	that	that	WDT
cord-328189-jpkxjn6e	102	19	serve	serve	VBP
cord-328189-jpkxjn6e	102	20	as	as	IN
cord-328189-jpkxjn6e	102	21	"	"	``
cord-328189-jpkxjn6e	102	22	hot	hot	JJ
cord-328189-jpkxjn6e	102	23	spots	spot	NNS
cord-328189-jpkxjn6e	102	24	"	"	''
cord-328189-jpkxjn6e	102	25	.	.	.
cord-328189-jpkxjn6e	103	1	Therefore	therefore	RB
cord-328189-jpkxjn6e	103	2	,	,	,
cord-328189-jpkxjn6e	103	3	we	-PRON-	PRP
cord-328189-jpkxjn6e	103	4	predict	predict	VBP
cord-328189-jpkxjn6e	103	5	that	that	IN
cord-328189-jpkxjn6e	103	6	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	103	7	RBD	RBD	NNP
cord-328189-jpkxjn6e	103	8	neutralizing	neutralize	VBG
cord-328189-jpkxjn6e	103	9	antibodies	antibody	NNS
cord-328189-jpkxjn6e	103	10	will	will	MD
cord-328189-jpkxjn6e	103	11	not	not	RB
cord-328189-jpkxjn6e	103	12	be	be	VB
cord-328189-jpkxjn6e	103	13	effective	effective	JJ
cord-328189-jpkxjn6e	103	14	for	for	IN
cord-328189-jpkxjn6e	103	15	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	103	16	.	.	.
cord-328189-jpkxjn6e	104	1	The	the	DT
cord-328189-jpkxjn6e	104	2	failure	failure	NN
cord-328189-jpkxjn6e	104	3	of	of	IN
cord-328189-jpkxjn6e	104	4	several	several	JJ
cord-328189-jpkxjn6e	104	5	of	of	IN
cord-328189-jpkxjn6e	104	6	these	these	DT
cord-328189-jpkxjn6e	104	7	antibodies	antibody	NNS
cord-328189-jpkxjn6e	104	8	to	to	TO
cord-328189-jpkxjn6e	104	9	neutralize	neutralize	VB
cord-328189-jpkxjn6e	104	10	the	the	DT
cord-328189-jpkxjn6e	104	11	binding	binding	NN
cord-328189-jpkxjn6e	104	12	of	of	IN
cord-328189-jpkxjn6e	104	13	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	104	14	RBD	RBD	NNP
cord-328189-jpkxjn6e	104	15	to	to	IN
cord-328189-jpkxjn6e	104	16	its	-PRON-	PRP$
cord-328189-jpkxjn6e	104	17	receptor	receptor	NN
cord-328189-jpkxjn6e	104	18	is	be	VBZ
cord-328189-jpkxjn6e	104	19	consistent	consistent	JJ
cord-328189-jpkxjn6e	104	20	with	with	IN
cord-328189-jpkxjn6e	104	21	our	-PRON-	PRP$
cord-328189-jpkxjn6e	104	22	findings	finding	NNS
cord-328189-jpkxjn6e	104	23	(	(	-LRB-
cord-328189-jpkxjn6e	104	24	20	20	CD
cord-328189-jpkxjn6e	104	25	,	,	,
cord-328189-jpkxjn6e	104	26	23	23	CD
cord-328189-jpkxjn6e	104	27	)	)	-RRB-
cord-328189-jpkxjn6e	104	28	.	.	.
cord-328189-jpkxjn6e	105	1	The	the	DT
cord-328189-jpkxjn6e	105	2	fluctuation	fluctuation	NN
cord-328189-jpkxjn6e	105	3	from	from	IN
cord-328189-jpkxjn6e	105	4	high	high	JJ
cord-328189-jpkxjn6e	105	5	-	-	HYPH
cord-328189-jpkxjn6e	105	6	to	to	IN
cord-328189-jpkxjn6e	105	7	low	low	JJ
cord-328189-jpkxjn6e	105	8	-	-	HYPH
cord-328189-jpkxjn6e	105	9	affinity	affinity	NN
cord-328189-jpkxjn6e	105	10	conformations	conformation	NNS
cord-328189-jpkxjn6e	105	11	in	in	IN
cord-328189-jpkxjn6e	105	12	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	105	13	leads	lead	VBZ
cord-328189-jpkxjn6e	105	14	to	to	IN
cord-328189-jpkxjn6e	105	15	an	an	DT
cord-328189-jpkxjn6e	105	16	increased	increase	VBN
cord-328189-jpkxjn6e	105	17	efficacy	efficacy	NN
cord-328189-jpkxjn6e	105	18	for	for	IN
cord-328189-jpkxjn6e	105	19	inhibiting	inhibit	VBG
cord-328189-jpkxjn6e	105	20	peptides	peptide	NNS
cord-328189-jpkxjn6e	105	21	(	(	-LRB-
cord-328189-jpkxjn6e	105	22	24	24	CD
cord-328189-jpkxjn6e	105	23	)	)	-RRB-
cord-328189-jpkxjn6e	105	24	and	and	CC
cord-328189-jpkxjn6e	105	25	high	high	JJ
cord-328189-jpkxjn6e	105	26	-	-	HYPH
cord-328189-jpkxjn6e	105	27	affinity	affinity	NN
cord-328189-jpkxjn6e	105	28	antibodies	antibody	NNS
cord-328189-jpkxjn6e	105	29	(	(	-LRB-
cord-328189-jpkxjn6e	105	30	25	25	CD
cord-328189-jpkxjn6e	105	31	)	)	-RRB-
cord-328189-jpkxjn6e	105	32	compared	compare	VBN
cord-328189-jpkxjn6e	105	33	to	to	IN
cord-328189-jpkxjn6e	105	34	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	105	35	.	.	.
cord-328189-jpkxjn6e	106	1	This	this	DT
cord-328189-jpkxjn6e	106	2	implies	imply	VBZ
cord-328189-jpkxjn6e	106	3	a	a	DT
cord-328189-jpkxjn6e	106	4	therapeutic	therapeutic	JJ
cord-328189-jpkxjn6e	106	5	challenge	challenge	NN
cord-328189-jpkxjn6e	106	6	is	be	VBZ
cord-328189-jpkxjn6e	106	7	attributed	attribute	VBN
cord-328189-jpkxjn6e	106	8	to	to	IN
cord-328189-jpkxjn6e	106	9	the	the	DT
cord-328189-jpkxjn6e	106	10	enhanced	enhance	VBN
cord-328189-jpkxjn6e	106	11	rigidity	rigidity	NN
cord-328189-jpkxjn6e	106	12	of	of	IN
cord-328189-jpkxjn6e	106	13	the	the	DT
cord-328189-jpkxjn6e	106	14	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	106	15	RBD	RBD	NNP
cord-328189-jpkxjn6e	106	16	relative	relative	NN
cord-328189-jpkxjn6e	106	17	to	to	IN
cord-328189-jpkxjn6e	106	18	that	that	DT
cord-328189-jpkxjn6e	106	19	of	of	IN
cord-328189-jpkxjn6e	106	20	the	the	DT
cord-328189-jpkxjn6e	106	21	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	106	22	.	.	.
cord-328189-jpkxjn6e	107	1	The	the	DT
cord-328189-jpkxjn6e	107	2	geometric	geometric	JJ
cord-328189-jpkxjn6e	107	3	and	and	CC
cord-328189-jpkxjn6e	107	4	physicochemical	physicochemical	JJ
cord-328189-jpkxjn6e	107	5	properties	property	NNS
cord-328189-jpkxjn6e	107	6	of	of	IN
cord-328189-jpkxjn6e	107	7	RBD	RBD	NNP
cord-328189-jpkxjn6e	107	8	-	-	HYPH
cord-328189-jpkxjn6e	107	9	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	107	10	interfaces	interface	NNS
cord-328189-jpkxjn6e	107	11	resemble	resemble	VBP
cord-328189-jpkxjn6e	107	12	those	those	DT
cord-328189-jpkxjn6e	107	13	of	of	IN
cord-328189-jpkxjn6e	107	14	antibody	antibody	NN
cord-328189-jpkxjn6e	107	15	-	-	HYPH
cord-328189-jpkxjn6e	107	16	antigen	antigen	NN
cord-328189-jpkxjn6e	107	17	interactions	interaction	NNS
cord-328189-jpkxjn6e	107	18	.	.	.
cord-328189-jpkxjn6e	108	1	In	in	IN
cord-328189-jpkxjn6e	108	2	both	both	DT
cord-328189-jpkxjn6e	108	3	cases	case	NNS
cord-328189-jpkxjn6e	108	4	the	the	DT
cord-328189-jpkxjn6e	108	5	interface	interface	NN
cord-328189-jpkxjn6e	108	6	benefits	benefit	NNS
cord-328189-jpkxjn6e	108	7	from	from	IN
cord-328189-jpkxjn6e	108	8	long	long	JJ
cord-328189-jpkxjn6e	108	9	loop	loop	NN
cord-328189-jpkxjn6e	108	10	plasticity	plasticity	NN
cord-328189-jpkxjn6e	108	11	,	,	,
cord-328189-jpkxjn6e	108	12	bulky	bulky	JJ
cord-328189-jpkxjn6e	108	13	aromatic	aromatic	JJ
cord-328189-jpkxjn6e	108	14	side	side	NN
cord-328189-jpkxjn6e	108	15	chains	chain	NNS
cord-328189-jpkxjn6e	108	16	as	as	IN
cord-328189-jpkxjn6e	108	17	anchoring	anchor	VBG
cord-328189-jpkxjn6e	108	18	sites	site	NNS
cord-328189-jpkxjn6e	108	19	,	,	,
cord-328189-jpkxjn6e	108	20	and	and	CC
cord-328189-jpkxjn6e	108	21	the	the	DT
cord-328189-jpkxjn6e	108	22	stabilization	stabilization	NN
cord-328189-jpkxjn6e	108	23	of	of	IN
cord-328189-jpkxjn6e	108	24	the	the	DT
cord-328189-jpkxjn6e	108	25	complex	complex	NN
cord-328189-jpkxjn6e	108	26	by	by	IN
cord-328189-jpkxjn6e	108	27	distributed	distribute	VBN
cord-328189-jpkxjn6e	108	28	electrostatic	electrostatic	JJ
cord-328189-jpkxjn6e	108	29	interactions	interaction	NNS
cord-328189-jpkxjn6e	108	30	(	(	-LRB-
cord-328189-jpkxjn6e	108	31	26	26	CD
cord-328189-jpkxjn6e	108	32	)	)	-RRB-
cord-328189-jpkxjn6e	108	33	.	.	.
cord-328189-jpkxjn6e	109	1	Both	both	DT
cord-328189-jpkxjn6e	109	2	COVID-19	covid-19	VBP
cord-328189-jpkxjn6e	109	3	and	and	CC
cord-328189-jpkxjn6e	109	4	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	109	5	interfaces	interface	NNS
cord-328189-jpkxjn6e	109	6	contain	contain	VBP
cord-328189-jpkxjn6e	109	7	long	long	JJ
cord-328189-jpkxjn6e	109	8	flexible	flexible	JJ
cord-328189-jpkxjn6e	109	9	loops	loop	NNS
cord-328189-jpkxjn6e	109	10	and	and	CC
cord-328189-jpkxjn6e	109	11	nine	nine	CD
cord-328189-jpkxjn6e	109	12	aromatic	aromatic	JJ
cord-328189-jpkxjn6e	109	13	residues	residue	NNS
cord-328189-jpkxjn6e	109	14	(	(	-LRB-
cord-328189-jpkxjn6e	109	15	Tyr	Tyr	NNP
cord-328189-jpkxjn6e	109	16	,	,	,
cord-328189-jpkxjn6e	109	17	Trp	Trp	NNP
cord-328189-jpkxjn6e	109	18	,	,	,
cord-328189-jpkxjn6e	109	19	Phe	Phe	NNP
cord-328189-jpkxjn6e	109	20	)	)	-RRB-
cord-328189-jpkxjn6e	109	21	in	in	IN
cord-328189-jpkxjn6e	109	22	the	the	DT
cord-328189-jpkxjn6e	109	23	interface	interface	NN
cord-328189-jpkxjn6e	109	24	with	with	IN
cord-328189-jpkxjn6e	109	25	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	109	26	(	(	-LRB-
cord-328189-jpkxjn6e	109	27	Fig	Fig	NNP
cord-328189-jpkxjn6e	109	28	.	.	.
cord-328189-jpkxjn6e	109	29	2A	2a	CD
cord-328189-jpkxjn6e	109	30	)	)	-RRB-
cord-328189-jpkxjn6e	109	31	.	.	.
cord-328189-jpkxjn6e	110	1	Moreover	moreover	RB
cord-328189-jpkxjn6e	110	2	,	,	,
cord-328189-jpkxjn6e	110	3	in	in	IN
cord-328189-jpkxjn6e	110	4	the	the	DT
cord-328189-jpkxjn6e	110	5	SARS	SARS	NNP
cord-328189-jpkxjn6e	110	6	designed	design	VBN
cord-328189-jpkxjn6e	110	7	variant	variant	NN
cord-328189-jpkxjn6e	110	8	(	(	-LRB-
cord-328189-jpkxjn6e	110	9	SARS	SARS	NNP
cord-328189-jpkxjn6e	110	10	-	-	HYPH
cord-328189-jpkxjn6e	110	11	des	des	NNP
cord-328189-jpkxjn6e	110	12	(	(	-LRB-
cord-328189-jpkxjn6e	110	13	11	11	CD
cord-328189-jpkxjn6e	110	14	)	)	-RRB-
cord-328189-jpkxjn6e	110	15	)	)	-RRB-
cord-328189-jpkxjn6e	110	16	,	,	,
cord-328189-jpkxjn6e	110	17	the	the	DT
cord-328189-jpkxjn6e	110	18	addition	addition	NN
cord-328189-jpkxjn6e	110	19	of	of	IN
cord-328189-jpkxjn6e	110	20	an	an	DT
cord-328189-jpkxjn6e	110	21	aromatic	aromatic	JJ
cord-328189-jpkxjn6e	110	22	residue	residue	NN
cord-328189-jpkxjn6e	110	23	(	(	-LRB-
cord-328189-jpkxjn6e	110	24	L486F	L486F	NNP
cord-328189-jpkxjn6e	110	25	substitution	substitution	NN
cord-328189-jpkxjn6e	110	26	)	)	-RRB-
cord-328189-jpkxjn6e	110	27	significantly	significantly	RB
cord-328189-jpkxjn6e	110	28	improved	improve	VBD
cord-328189-jpkxjn6e	110	29	the	the	DT
cord-328189-jpkxjn6e	110	30	interaction	interaction	NN
cord-328189-jpkxjn6e	110	31	scores	score	NNS
cord-328189-jpkxjn6e	110	32	and	and	CC
cord-328189-jpkxjn6e	110	33	interface	interface	NN
cord-328189-jpkxjn6e	110	34	stability	stability	NN
cord-328189-jpkxjn6e	110	35	(	(	-LRB-
cord-328189-jpkxjn6e	110	36	Fig	Fig	NNP
cord-328189-jpkxjn6e	110	37	.	.	.
cord-328189-jpkxjn6e	110	38	3	3	CD
cord-328189-jpkxjn6e	110	39	,	,	,
cord-328189-jpkxjn6e	110	40	 	 	_SP
cord-328189-jpkxjn6e	110	41	B	B	NNP
cord-328189-jpkxjn6e	110	42	and	and	CC
cord-328189-jpkxjn6e	110	43	D	D	NNP
cord-328189-jpkxjn6e	110	44	)	)	-RRB-
cord-328189-jpkxjn6e	110	45	.	.	.
cord-328189-jpkxjn6e	111	1	Our	-PRON-	PRP$
cord-328189-jpkxjn6e	111	2	findings	finding	NNS
cord-328189-jpkxjn6e	111	3	shed	shed	VBP
cord-328189-jpkxjn6e	111	4	light	light	NN
cord-328189-jpkxjn6e	111	5	on	on	IN
cord-328189-jpkxjn6e	111	6	the	the	DT
cord-328189-jpkxjn6e	111	7	accelerated	accelerated	JJ
cord-328189-jpkxjn6e	111	8	evolution	evolution	NN
cord-328189-jpkxjn6e	111	9	of	of	IN
cord-328189-jpkxjn6e	111	10	spike	spike	NN
cord-328189-jpkxjn6e	111	11	protein	protein	NN
cord-328189-jpkxjn6e	111	12	binding	bind	VBG
cord-328189-jpkxjn6e	111	13	to	to	IN
cord-328189-jpkxjn6e	111	14	the	the	DT
cord-328189-jpkxjn6e	111	15	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	111	16	receptor	receptor	NN
cord-328189-jpkxjn6e	111	17	similar	similar	JJ
cord-328189-jpkxjn6e	111	18	to	to	IN
cord-328189-jpkxjn6e	111	19	the	the	DT
cord-328189-jpkxjn6e	111	20	rapid	rapid	JJ
cord-328189-jpkxjn6e	111	21	evolution	evolution	NN
cord-328189-jpkxjn6e	111	22	along	along	IN
cord-328189-jpkxjn6e	111	23	the	the	DT
cord-328189-jpkxjn6e	111	24	antibody	antibody	NN
cord-328189-jpkxjn6e	111	25	-	-	HYPH
cord-328189-jpkxjn6e	111	26	antigen	antigen	NN
cord-328189-jpkxjn6e	111	27	affinity	affinity	NN
cord-328189-jpkxjn6e	111	28	maturation	maturation	NN
cord-328189-jpkxjn6e	111	29	process	process	NN
cord-328189-jpkxjn6e	111	30	.	.	.
cord-328189-jpkxjn6e	112	1	Structural	structural	JJ
cord-328189-jpkxjn6e	112	2	modeling	model	VBG
cord-328189-jpkxjn6e	112	3	The	the	DT
cord-328189-jpkxjn6e	112	4	structural	structural	JJ
cord-328189-jpkxjn6e	112	5	model	model	NN
cord-328189-jpkxjn6e	112	6	of	of	IN
cord-328189-jpkxjn6e	112	7	the	the	DT
cord-328189-jpkxjn6e	112	8	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	112	9	spike	spike	NN
cord-328189-jpkxjn6e	112	10	protein	protein	NN
cord-328189-jpkxjn6e	112	11	receptor	receptor	NN
cord-328189-jpkxjn6e	112	12	binding	bind	VBG
cord-328189-jpkxjn6e	112	13	domain	domain	NN
cord-328189-jpkxjn6e	112	14	(	(	-LRB-
cord-328189-jpkxjn6e	112	15	RBD	RBD	NNP
cord-328189-jpkxjn6e	112	16	)	)	-RRB-
cord-328189-jpkxjn6e	112	17	in	in	IN
cord-328189-jpkxjn6e	112	18	complex	complex	NN
cord-328189-jpkxjn6e	112	19	with	with	IN
cord-328189-jpkxjn6e	112	20	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	112	21	was	be	VBD
cord-328189-jpkxjn6e	112	22	generated	generate	VBN
cord-328189-jpkxjn6e	112	23	by	by	IN
cord-328189-jpkxjn6e	112	24	comparative	comparative	JJ
cord-328189-jpkxjn6e	112	25	modeling	modeling	NN
cord-328189-jpkxjn6e	112	26	using	use	VBG
cord-328189-jpkxjn6e	112	27	Modeller	Modeller	NNP
cord-328189-jpkxjn6e	112	28	9.18	9.18	CD
cord-328189-jpkxjn6e	112	29	(	(	-LRB-
cord-328189-jpkxjn6e	112	30	27	27	CD
cord-328189-jpkxjn6e	112	31	)	)	-RRB-
cord-328189-jpkxjn6e	112	32	with	with	IN
cord-328189-jpkxjn6e	112	33	the	the	DT
cord-328189-jpkxjn6e	112	34	COVID-19	covid-19	JJ
cord-328189-jpkxjn6e	112	35	sequence	sequence	NN
cord-328189-jpkxjn6e	112	36	(	(	-LRB-
cord-328189-jpkxjn6e	112	37	RefSeq	RefSeq	NNP
cord-328189-jpkxjn6e	112	38	:	:	:
cord-328189-jpkxjn6e	112	39	YP_009724390.1	YP_009724390.1	NNP
cord-328189-jpkxjn6e	112	40	)	)	-RRB-
cord-328189-jpkxjn6e	112	41	.	.	.
cord-328189-jpkxjn6e	113	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	113	2	relied	rely	VBD
cord-328189-jpkxjn6e	113	3	on	on	IN
cord-328189-jpkxjn6e	113	4	the	the	DT
cord-328189-jpkxjn6e	113	5	crystal	crystal	JJ
cord-328189-jpkxjn6e	113	6	structure	structure	NN
cord-328189-jpkxjn6e	113	7	of	of	IN
cord-328189-jpkxjn6e	113	8	the	the	DT
cord-328189-jpkxjn6e	113	9	spike	spike	NN
cord-328189-jpkxjn6e	113	10	protein	protein	NN
cord-328189-jpkxjn6e	113	11	receptor	receptor	NN
cord-328189-jpkxjn6e	113	12	-	-	HYPH
cord-328189-jpkxjn6e	113	13	binding	bind	VBG
cord-328189-jpkxjn6e	113	14	domain	domain	NN
cord-328189-jpkxjn6e	113	15	from	from	IN
cord-328189-jpkxjn6e	113	16	a	a	DT
cord-328189-jpkxjn6e	113	17	SARS	SARS	NNP
cord-328189-jpkxjn6e	113	18	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	113	19	designed	design	VBN
cord-328189-jpkxjn6e	113	20	human	human	JJ
cord-328189-jpkxjn6e	113	21	strain	strain	NN
cord-328189-jpkxjn6e	113	22	complexed	complexe	VBN
cord-328189-jpkxjn6e	113	23	with	with	IN
cord-328189-jpkxjn6e	113	24	the	the	DT
cord-328189-jpkxjn6e	113	25	human	human	JJ
cord-328189-jpkxjn6e	113	26	receptor	receptor	NN
cord-328189-jpkxjn6e	113	27	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	113	28	(	(	-LRB-
cord-328189-jpkxjn6e	113	29	PDB	PDB	NNP
cord-328189-jpkxjn6e	113	30	3SCI	3sci	CD
cord-328189-jpkxjn6e	113	31	,	,	,
cord-328189-jpkxjn6e	113	32	resolution	resolution	NN
cord-328189-jpkxjn6e	113	33	2.9Å	2.9Å	NNP
cord-328189-jpkxjn6e	113	34	)	)	-RRB-
cord-328189-jpkxjn6e	113	35	as	as	IN
cord-328189-jpkxjn6e	113	36	a	a	DT
cord-328189-jpkxjn6e	113	37	template	template	NN
cord-328189-jpkxjn6e	113	38	for	for	IN
cord-328189-jpkxjn6e	113	39	comparative	comparative	JJ
cord-328189-jpkxjn6e	113	40	modeling	modeling	NN
cord-328189-jpkxjn6e	113	41	.	.	.
cord-328189-jpkxjn6e	114	1	The	the	DT
cord-328189-jpkxjn6e	114	2	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	114	3	spike	spike	NN
cord-328189-jpkxjn6e	114	4	protein	protein	NN
cord-328189-jpkxjn6e	114	5	RBD	RBD	NNP
cord-328189-jpkxjn6e	114	6	and	and	CC
cord-328189-jpkxjn6e	114	7	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	114	8	-	-	HYPH
cord-328189-jpkxjn6e	114	9	NL63	NL63	NNP
cord-328189-jpkxjn6e	114	10	in	in	IN
cord-328189-jpkxjn6e	114	11	complex	complex	NN
cord-328189-jpkxjn6e	114	12	with	with	IN
cord-328189-jpkxjn6e	114	13	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	114	14	were	be	VBD
cord-328189-jpkxjn6e	114	15	taken	take	VBN
cord-328189-jpkxjn6e	114	16	from	from	IN
cord-328189-jpkxjn6e	114	17	PDB	PDB	NNP
cord-328189-jpkxjn6e	114	18	2AJF	2AJF	NNP
cord-328189-jpkxjn6e	114	19	(	(	-LRB-
cord-328189-jpkxjn6e	114	20	resolution	resolution	NN
cord-328189-jpkxjn6e	114	21	2.9Å	2.9Å	NNP
cord-328189-jpkxjn6e	114	22	)	)	-RRB-
cord-328189-jpkxjn6e	114	23	and	and	CC
cord-328189-jpkxjn6e	114	24	3KBH	3kbh	LS
cord-328189-jpkxjn6e	114	25	(	(	-LRB-
cord-328189-jpkxjn6e	114	26	resolution	resolution	NN
cord-328189-jpkxjn6e	114	27	3.3Å	3.3Å	NNP
cord-328189-jpkxjn6e	114	28	)	)	-RRB-
cord-328189-jpkxjn6e	114	29	,	,	,
cord-328189-jpkxjn6e	114	30	respectively	respectively	RB
cord-328189-jpkxjn6e	114	31	.	.	.
cord-328189-jpkxjn6e	115	1	Missing	miss	VBG
cord-328189-jpkxjn6e	115	2	residues	residue	NNS
cord-328189-jpkxjn6e	115	3	were	be	VBD
cord-328189-jpkxjn6e	115	4	added	add	VBN
cord-328189-jpkxjn6e	115	5	in	in	IN
cord-328189-jpkxjn6e	115	6	MODELLER	MODELLER	NNP
cord-328189-jpkxjn6e	115	7	.	.	.
cord-328189-jpkxjn6e	116	1	MERS	MERS	NNP
cord-328189-jpkxjn6e	116	2	RBD	RBD	NNP
cord-328189-jpkxjn6e	116	3	structure	structure	NN
cord-328189-jpkxjn6e	116	4	was	be	VBD
cord-328189-jpkxjn6e	116	5	taken	take	VBN
cord-328189-jpkxjn6e	116	6	from	from	IN
cord-328189-jpkxjn6e	116	7	the	the	DT
cord-328189-jpkxjn6e	116	8	complex	complex	NN
cord-328189-jpkxjn6e	116	9	with	with	IN
cord-328189-jpkxjn6e	116	10	the	the	DT
cord-328189-jpkxjn6e	116	11	neutralizing	neutralize	VBG
cord-328189-jpkxjn6e	116	12	antibody	antibody	NN
cord-328189-jpkxjn6e	116	13	CDC2-C2	CDC2-C2	NNP
cord-328189-jpkxjn6e	116	14	(	(	-LRB-
cord-328189-jpkxjn6e	116	15	PDB	PDB	NNP
cord-328189-jpkxjn6e	116	16	6C6Z	6c6z	CD
cord-328189-jpkxjn6e	116	17	,	,	,
cord-328189-jpkxjn6e	116	18	resolution	resolution	NN
cord-328189-jpkxjn6e	116	19	2.1Å	2.1å	JJ
cord-328189-jpkxjn6e	116	20	)	)	-RRB-
cord-328189-jpkxjn6e	116	21	and	and	CC
cord-328189-jpkxjn6e	116	22	structurally	structurally	RB
cord-328189-jpkxjn6e	116	23	aligned	align	VBN
cord-328189-jpkxjn6e	116	24	onto	onto	IN
cord-328189-jpkxjn6e	116	25	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	116	26	RBD	RBD	NNP
cord-328189-jpkxjn6e	116	27	in	in	IN
cord-328189-jpkxjn6e	116	28	complex	complex	NN
cord-328189-jpkxjn6e	116	29	with	with	IN
cord-328189-jpkxjn6e	116	30	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	116	31	receptor	receptor	NN
cord-328189-jpkxjn6e	116	32	.	.	.
cord-328189-jpkxjn6e	117	1	The	the	DT
cord-328189-jpkxjn6e	117	2	designed	design	VBN
cord-328189-jpkxjn6e	117	3	variant	variant	NN
cord-328189-jpkxjn6e	117	4	is	be	VBZ
cord-328189-jpkxjn6e	117	5	from	from	IN
cord-328189-jpkxjn6e	117	6	PDB	PDB	NNP
cord-328189-jpkxjn6e	117	7	3SCI	3sci	CD
cord-328189-jpkxjn6e	117	8	.	.	.
cord-328189-jpkxjn6e	118	1	The	the	DT
cord-328189-jpkxjn6e	118	2	MD	MD	NNP
cord-328189-jpkxjn6e	118	3	simulations	simulation	NNS
cord-328189-jpkxjn6e	118	4	were	be	VBD
cord-328189-jpkxjn6e	118	5	performed	perform	VBN
cord-328189-jpkxjn6e	118	6	with	with	IN
cord-328189-jpkxjn6e	118	7	GROMACS	GROMACS	NNP
cord-328189-jpkxjn6e	118	8	2020	2020	CD
cord-328189-jpkxjn6e	118	9	software	software	NN
cord-328189-jpkxjn6e	118	10	(	(	-LRB-
cord-328189-jpkxjn6e	118	11	28	28	CD
cord-328189-jpkxjn6e	118	12	)	)	-RRB-
cord-328189-jpkxjn6e	118	13	using	use	VBG
cord-328189-jpkxjn6e	118	14	the	the	DT
cord-328189-jpkxjn6e	118	15	CHARMM36	CHARMM36	NNP
cord-328189-jpkxjn6e	118	16	m	m	NNP
cord-328189-jpkxjn6e	118	17	force	force	NNP
cord-328189-jpkxjn6e	118	18	field	field	NN
cord-328189-jpkxjn6e	118	19	(	(	-LRB-
cord-328189-jpkxjn6e	118	20	29	29	CD
cord-328189-jpkxjn6e	118	21	)	)	-RRB-
cord-328189-jpkxjn6e	118	22	.	.	.
cord-328189-jpkxjn6e	119	1	Each	each	DT
cord-328189-jpkxjn6e	119	2	of	of	IN
cord-328189-jpkxjn6e	119	3	the	the	DT
cord-328189-jpkxjn6e	119	4	complexes	complex	NNS
cord-328189-jpkxjn6e	119	5	was	be	VBD
cord-328189-jpkxjn6e	119	6	solvated	solvate	VBN
cord-328189-jpkxjn6e	119	7	in	in	IN
cord-328189-jpkxjn6e	119	8	transferable	transferable	JJ
cord-328189-jpkxjn6e	119	9	intermolecular	intermolecular	JJ
cord-328189-jpkxjn6e	119	10	potential	potential	NN
cord-328189-jpkxjn6e	119	11	with	with	IN
cord-328189-jpkxjn6e	119	12	3	3	CD
cord-328189-jpkxjn6e	119	13	points	point	NNS
cord-328189-jpkxjn6e	119	14	(	(	-LRB-
cord-328189-jpkxjn6e	119	15	TIP3P	tip3p	CD
cord-328189-jpkxjn6e	119	16	)	)	-RRB-
cord-328189-jpkxjn6e	119	17	water	water	NN
cord-328189-jpkxjn6e	119	18	molecules	molecule	NNS
cord-328189-jpkxjn6e	119	19	and	and	CC
cord-328189-jpkxjn6e	119	20	ions	ion	NNS
cord-328189-jpkxjn6e	119	21	were	be	VBD
cord-328189-jpkxjn6e	119	22	added	add	VBN
cord-328189-jpkxjn6e	119	23	to	to	TO
cord-328189-jpkxjn6e	119	24	equalize	equalize	VB
cord-328189-jpkxjn6e	119	25	the	the	DT
cord-328189-jpkxjn6e	119	26	total	total	JJ
cord-328189-jpkxjn6e	119	27	system	system	NN
cord-328189-jpkxjn6e	119	28	charge	charge	NN
cord-328189-jpkxjn6e	119	29	.	.	.
cord-328189-jpkxjn6e	120	1	The	the	DT
cord-328189-jpkxjn6e	120	2	steepest	steep	JJS
cord-328189-jpkxjn6e	120	3	descent	descent	NN
cord-328189-jpkxjn6e	120	4	algorithm	algorithm	NN
cord-328189-jpkxjn6e	120	5	was	be	VBD
cord-328189-jpkxjn6e	120	6	used	use	VBN
cord-328189-jpkxjn6e	120	7	for	for	IN
cord-328189-jpkxjn6e	120	8	initial	initial	JJ
cord-328189-jpkxjn6e	120	9	energy	energy	NN
cord-328189-jpkxjn6e	120	10	minimization	minimization	NN
cord-328189-jpkxjn6e	120	11	until	until	IN
cord-328189-jpkxjn6e	120	12	the	the	DT
cord-328189-jpkxjn6e	120	13	system	system	NN
cord-328189-jpkxjn6e	120	14	converged	converge	VBD
cord-328189-jpkxjn6e	120	15	at	at	IN
cord-328189-jpkxjn6e	120	16	Fmax	Fmax	NNP
cord-328189-jpkxjn6e	120	17	<	<	XX
cord-328189-jpkxjn6e	120	18	1,000	1,000	CD
cord-328189-jpkxjn6e	120	19	kJ/(mol	kJ/(mol	NNP
cord-328189-jpkxjn6e	120	20	·	·	NFP
cord-328189-jpkxjn6e	120	21	nm	nm	NN
cord-328189-jpkxjn6e	120	22	)	)	-RRB-
cord-328189-jpkxjn6e	120	23	.	.	.
cord-328189-jpkxjn6e	121	1	Then	then	RB
cord-328189-jpkxjn6e	121	2	water	water	NN
cord-328189-jpkxjn6e	121	3	and	and	CC
cord-328189-jpkxjn6e	121	4	ions	ion	NNS
cord-328189-jpkxjn6e	121	5	were	be	VBD
cord-328189-jpkxjn6e	121	6	allowed	allow	VBN
cord-328189-jpkxjn6e	121	7	to	to	TO
cord-328189-jpkxjn6e	121	8	equilibrate	equilibrate	VB
cord-328189-jpkxjn6e	121	9	around	around	IN
cord-328189-jpkxjn6e	121	10	the	the	DT
cord-328189-jpkxjn6e	121	11	protein	protein	NN
cord-328189-jpkxjn6e	121	12	in	in	IN
cord-328189-jpkxjn6e	121	13	a	a	DT
cord-328189-jpkxjn6e	121	14	two	two	CD
cord-328189-jpkxjn6e	121	15	-	-	HYPH
cord-328189-jpkxjn6e	121	16	step	step	NN
cord-328189-jpkxjn6e	121	17	equilibration	equilibration	NN
cord-328189-jpkxjn6e	121	18	process	process	NN
cord-328189-jpkxjn6e	121	19	.	.	.
cord-328189-jpkxjn6e	122	1	The	the	DT
cord-328189-jpkxjn6e	122	2	first	first	JJ
cord-328189-jpkxjn6e	122	3	part	part	NN
cord-328189-jpkxjn6e	122	4	of	of	IN
cord-328189-jpkxjn6e	122	5	equilibration	equilibration	NN
cord-328189-jpkxjn6e	122	6	was	be	VBD
cord-328189-jpkxjn6e	122	7	at	at	IN
cord-328189-jpkxjn6e	122	8	a	a	DT
cord-328189-jpkxjn6e	122	9	constant	constant	JJ
cord-328189-jpkxjn6e	122	10	number	number	NN
cord-328189-jpkxjn6e	122	11	of	of	IN
cord-328189-jpkxjn6e	122	12	particles	particle	NNS
cord-328189-jpkxjn6e	122	13	,	,	,
cord-328189-jpkxjn6e	122	14	volume	volume	NN
cord-328189-jpkxjn6e	122	15	,	,	,
cord-328189-jpkxjn6e	122	16	and	and	CC
cord-328189-jpkxjn6e	122	17	temperature	temperature	NN
cord-328189-jpkxjn6e	122	18	(	(	-LRB-
cord-328189-jpkxjn6e	122	19	NVT	NVT	NNP
cord-328189-jpkxjn6e	122	20	)	)	-RRB-
cord-328189-jpkxjn6e	122	21	.	.	.
cord-328189-jpkxjn6e	123	1	The	the	DT
cord-328189-jpkxjn6e	123	2	second	second	JJ
cord-328189-jpkxjn6e	123	3	part	part	NN
cord-328189-jpkxjn6e	123	4	of	of	IN
cord-328189-jpkxjn6e	123	5	equilibration	equilibration	NN
cord-328189-jpkxjn6e	123	6	was	be	VBD
cord-328189-jpkxjn6e	123	7	at	at	IN
cord-328189-jpkxjn6e	123	8	a	a	DT
cord-328189-jpkxjn6e	123	9	constant	constant	JJ
cord-328189-jpkxjn6e	123	10	number	number	NN
cord-328189-jpkxjn6e	123	11	of	of	IN
cord-328189-jpkxjn6e	123	12	particles	particle	NNS
cord-328189-jpkxjn6e	123	13	,	,	,
cord-328189-jpkxjn6e	123	14	pressure	pressure	NN
cord-328189-jpkxjn6e	123	15	,	,	,
cord-328189-jpkxjn6e	123	16	and	and	CC
cord-328189-jpkxjn6e	123	17	temperature	temperature	NN
cord-328189-jpkxjn6e	123	18	(	(	-LRB-
cord-328189-jpkxjn6e	123	19	NPT	NPT	NNP
cord-328189-jpkxjn6e	123	20	)	)	-RRB-
cord-328189-jpkxjn6e	123	21	.	.	.
cord-328189-jpkxjn6e	124	1	For	for	IN
cord-328189-jpkxjn6e	124	2	both	both	DT
cord-328189-jpkxjn6e	124	3	MD	MD	NNP
cord-328189-jpkxjn6e	124	4	equilibration	equilibration	NN
cord-328189-jpkxjn6e	124	5	parts	part	NNS
cord-328189-jpkxjn6e	124	6	,	,	,
cord-328189-jpkxjn6e	124	7	positional	positional	JJ
cord-328189-jpkxjn6e	124	8	restraints	restraint	NNS
cord-328189-jpkxjn6e	124	9	of	of	IN
cord-328189-jpkxjn6e	124	10	k	k	NN
cord-328189-jpkxjn6e	124	11	=	=	SYM
cord-328189-jpkxjn6e	124	12	1,000	1,000	CD
cord-328189-jpkxjn6e	124	13	kJ/(mol	kJ/(mol	NNP
cord-328189-jpkxjn6e	124	14	·	·	NFP
cord-328189-jpkxjn6e	124	15	nm	nm	NN
cord-328189-jpkxjn6e	124	16	2	2	CD
cord-328189-jpkxjn6e	124	17	)	)	-RRB-
cord-328189-jpkxjn6e	124	18	were	be	VBD
cord-328189-jpkxjn6e	124	19	applied	apply	VBN
cord-328189-jpkxjn6e	124	20	to	to	IN
cord-328189-jpkxjn6e	124	21	heavy	heavy	JJ
cord-328189-jpkxjn6e	124	22	atoms	atom	NNS
cord-328189-jpkxjn6e	124	23	of	of	IN
cord-328189-jpkxjn6e	124	24	the	the	DT
cord-328189-jpkxjn6e	124	25	protein	protein	NN
cord-328189-jpkxjn6e	124	26	,	,	,
cord-328189-jpkxjn6e	124	27	and	and	CC
cord-328189-jpkxjn6e	124	28	the	the	DT
cord-328189-jpkxjn6e	124	29	system	system	NN
cord-328189-jpkxjn6e	124	30	was	be	VBD
cord-328189-jpkxjn6e	124	31	allowed	allow	VBN
cord-328189-jpkxjn6e	124	32	to	to	TO
cord-328189-jpkxjn6e	124	33	equilibrate	equilibrate	VB
cord-328189-jpkxjn6e	124	34	at	at	IN
cord-328189-jpkxjn6e	124	35	a	a	DT
cord-328189-jpkxjn6e	124	36	reference	reference	NN
cord-328189-jpkxjn6e	124	37	temperature	temperature	NN
cord-328189-jpkxjn6e	124	38	of	of	IN
cord-328189-jpkxjn6e	124	39	300	300	CD
cord-328189-jpkxjn6e	124	40	K	k	NN
cord-328189-jpkxjn6e	124	41	,	,	,
cord-328189-jpkxjn6e	124	42	or	or	CC
cord-328189-jpkxjn6e	124	43	reference	reference	NN
cord-328189-jpkxjn6e	124	44	pressure	pressure	NN
cord-328189-jpkxjn6e	124	45	of	of	IN
cord-328189-jpkxjn6e	124	46	1	1	CD
cord-328189-jpkxjn6e	124	47	bar	bar	NN
cord-328189-jpkxjn6e	124	48	for	for	IN
cord-328189-jpkxjn6e	124	49	100	100	CD
cord-328189-jpkxjn6e	124	50	ps	p	NNS
cord-328189-jpkxjn6e	124	51	at	at	IN
cord-328189-jpkxjn6e	124	52	a	a	DT
cord-328189-jpkxjn6e	124	53	time	time	NN
cord-328189-jpkxjn6e	124	54	step	step	NN
cord-328189-jpkxjn6e	124	55	of	of	IN
cord-328189-jpkxjn6e	124	56	2	2	CD
cord-328189-jpkxjn6e	124	57	fs	f	NNS
cord-328189-jpkxjn6e	124	58	.	.	.
cord-328189-jpkxjn6e	125	1	Following	follow	VBG
cord-328189-jpkxjn6e	125	2	equilibration	equilibration	NN
cord-328189-jpkxjn6e	125	3	,	,	,
cord-328189-jpkxjn6e	125	4	the	the	DT
cord-328189-jpkxjn6e	125	5	production	production	NN
cord-328189-jpkxjn6e	125	6	simulation	simulation	NN
cord-328189-jpkxjn6e	125	7	duration	duration	NN
cord-328189-jpkxjn6e	125	8	was	be	VBD
cord-328189-jpkxjn6e	125	9	100	100	CD
cord-328189-jpkxjn6e	125	10	nanoseconds	nanosecond	NNS
cord-328189-jpkxjn6e	125	11	with	with	IN
cord-328189-jpkxjn6e	125	12	2	2	CD
cord-328189-jpkxjn6e	125	13	fs	f	NNS
cord-328189-jpkxjn6e	125	14	time	time	NN
cord-328189-jpkxjn6e	125	15	intervals	interval	NNS
cord-328189-jpkxjn6e	125	16	.	.	.
cord-328189-jpkxjn6e	126	1	Altogether	altogether	RB
cord-328189-jpkxjn6e	126	2	10,000	10,000	CD
cord-328189-jpkxjn6e	126	3	frames	frame	NNS
cord-328189-jpkxjn6e	126	4	were	be	VBD
cord-328189-jpkxjn6e	126	5	saved	save	VBN
cord-328189-jpkxjn6e	126	6	for	for	IN
cord-328189-jpkxjn6e	126	7	the	the	DT
cord-328189-jpkxjn6e	126	8	analysis	analysis	NN
cord-328189-jpkxjn6e	126	9	at	at	IN
cord-328189-jpkxjn6e	126	10	intervals	interval	NNS
cord-328189-jpkxjn6e	126	11	of	of	IN
cord-328189-jpkxjn6e	126	12	10	10	CD
cord-328189-jpkxjn6e	126	13	ps	ps	NN
cord-328189-jpkxjn6e	126	14	.	.	.
cord-328189-jpkxjn6e	127	1	We	-PRON-	PRP
cord-328189-jpkxjn6e	127	2	superimposed	superimpose	VBD
cord-328189-jpkxjn6e	127	3	several	several	JJ
cord-328189-jpkxjn6e	127	4	MD	MD	NNP
cord-328189-jpkxjn6e	127	5	snapshots	snapshot	NNS
cord-328189-jpkxjn6e	127	6	on	on	IN
cord-328189-jpkxjn6e	127	7	the	the	DT
cord-328189-jpkxjn6e	127	8	recently	recently	RB
cord-328189-jpkxjn6e	127	9	submitted	submit	VBN
cord-328189-jpkxjn6e	127	10	to	to	IN
cord-328189-jpkxjn6e	127	11	the	the	DT
cord-328189-jpkxjn6e	127	12	PDB	PDB	NNP
cord-328189-jpkxjn6e	127	13	x	x	NN
cord-328189-jpkxjn6e	127	14	-	-	NN
cord-328189-jpkxjn6e	127	15	ray	ray	NN
cord-328189-jpkxjn6e	127	16	structure	structure	NN
cord-328189-jpkxjn6e	127	17	(	(	-LRB-
cord-328189-jpkxjn6e	127	18	6VW1	6vw1	CD
cord-328189-jpkxjn6e	127	19	,	,	,
cord-328189-jpkxjn6e	127	20	resolution	resolution	NN
cord-328189-jpkxjn6e	127	21	2.7Å	2.7Å	NNS
cord-328189-jpkxjn6e	127	22	)	)	-RRB-
cord-328189-jpkxjn6e	127	23	of	of	IN
cord-328189-jpkxjn6e	127	24	COVID-19-ACE2	covid-19-ace2	JJ
cord-328189-jpkxjn6e	127	25	complex	complex	NN
cord-328189-jpkxjn6e	127	26	.	.	.
cord-328189-jpkxjn6e	128	1	The	the	DT
cord-328189-jpkxjn6e	128	2	average	average	JJ
cord-328189-jpkxjn6e	128	3	RMSD	RMSD	NNP
cord-328189-jpkxjn6e	128	4	over	over	IN
cord-328189-jpkxjn6e	128	5	the	the	DT
cord-328189-jpkxjn6e	128	6	interface	interface	NN
cord-328189-jpkxjn6e	129	1	Ca	ca	NN
cord-328189-jpkxjn6e	129	2	atoms	atom	NNS
cord-328189-jpkxjn6e	129	3	is	be	VBZ
cord-328189-jpkxjn6e	129	4	~1Å.	~1Å.	:
cord-328189-jpkxjn6e	129	5	Interaction	interaction	NN
cord-328189-jpkxjn6e	129	6	scores	score	NNS
cord-328189-jpkxjn6e	129	7	between	between	IN
cord-328189-jpkxjn6e	129	8	the	the	DT
cord-328189-jpkxjn6e	129	9	virus	virus	NN
cord-328189-jpkxjn6e	129	10	spike	spike	NN
cord-328189-jpkxjn6e	129	11	RBD	RBD	NNP
cord-328189-jpkxjn6e	129	12	and	and	CC
cord-328189-jpkxjn6e	129	13	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	129	14	were	be	VBD
cord-328189-jpkxjn6e	129	15	calculated	calculate	VBN
cord-328189-jpkxjn6e	129	16	for	for	IN
cord-328189-jpkxjn6e	129	17	each	each	DT
cord-328189-jpkxjn6e	129	18	frame	frame	NN
cord-328189-jpkxjn6e	129	19	of	of	IN
cord-328189-jpkxjn6e	129	20	the	the	DT
cord-328189-jpkxjn6e	129	21	trajectory	trajectory	NN
cord-328189-jpkxjn6e	129	22	using	use	VBG
cord-328189-jpkxjn6e	129	23	the	the	DT
cord-328189-jpkxjn6e	129	24	SOAP	soap	NN
cord-328189-jpkxjn6e	129	25	statistical	statistical	JJ
cord-328189-jpkxjn6e	129	26	potential	potential	NN
cord-328189-jpkxjn6e	129	27	(	(	-LRB-
cord-328189-jpkxjn6e	129	28	16	16	CD
cord-328189-jpkxjn6e	129	29	)	)	-RRB-
cord-328189-jpkxjn6e	129	30	.	.	.
cord-328189-jpkxjn6e	130	1	In	in	IN
cord-328189-jpkxjn6e	130	2	the	the	DT
cord-328189-jpkxjn6e	130	3	interface	interface	NN
cord-328189-jpkxjn6e	130	4	contact	contact	NN
cord-328189-jpkxjn6e	130	5	analysis	analysis	NN
cord-328189-jpkxjn6e	130	6	,	,	,
cord-328189-jpkxjn6e	130	7	a	a	DT
cord-328189-jpkxjn6e	130	8	residue	residue	NN
cord-328189-jpkxjn6e	130	9	-	-	HYPH
cord-328189-jpkxjn6e	130	10	residue	residue	NN
cord-328189-jpkxjn6e	130	11	contact	contact	NN
cord-328189-jpkxjn6e	130	12	was	be	VBD
cord-328189-jpkxjn6e	130	13	defined	define	VBN
cord-328189-jpkxjn6e	130	14	based	base	VBN
cord-328189-jpkxjn6e	130	15	on	on	IN
cord-328189-jpkxjn6e	130	16	the	the	DT
cord-328189-jpkxjn6e	130	17	inter	inter	JJ
cord-328189-jpkxjn6e	130	18	-	-	JJ
cord-328189-jpkxjn6e	130	19	atomic	atomic	JJ
cord-328189-jpkxjn6e	130	20	distance	distance	NN
cord-328189-jpkxjn6e	130	21	,	,	,
cord-328189-jpkxjn6e	130	22	with	with	IN
cord-328189-jpkxjn6e	130	23	a	a	DT
cord-328189-jpkxjn6e	130	24	cutoff	cutoff	NN
cord-328189-jpkxjn6e	130	25	of	of	IN
cord-328189-jpkxjn6e	130	26	4Å.	4å.	CD
cord-328189-jpkxjn6e	130	27	Table	table	NN
cord-328189-jpkxjn6e	130	28	S2	S2	NNP
cord-328189-jpkxjn6e	130	29	.	.	.
cord-328189-jpkxjn6e	131	1	RBD	RBD	NNP
cord-328189-jpkxjn6e	131	2	-	-	HYPH
cord-328189-jpkxjn6e	131	3	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	131	4	interface	interface	NN
cord-328189-jpkxjn6e	131	5	evaluated	evaluate	VBN
cord-328189-jpkxjn6e	131	6	by	by	IN
cord-328189-jpkxjn6e	131	7	several	several	JJ
cord-328189-jpkxjn6e	131	8	methods	method	NNS
cord-328189-jpkxjn6e	131	9	for	for	IN
cord-328189-jpkxjn6e	131	10	analysis	analysis	NN
cord-328189-jpkxjn6e	131	11	of	of	IN
cord-328189-jpkxjn6e	131	12	protein	protein	NN
cord-328189-jpkxjn6e	131	13	-	-	HYPH
cord-328189-jpkxjn6e	131	14	protein	protein	NN
cord-328189-jpkxjn6e	131	15	interactions	interaction	NNS
cord-328189-jpkxjn6e	131	16	Movie	Movie	NNP
cord-328189-jpkxjn6e	131	17	S1	S1	NNP
cord-328189-jpkxjn6e	131	18	.	.	.
cord-328189-jpkxjn6e	132	1	Overlay	overlay	NN
cord-328189-jpkxjn6e	132	2	of	of	IN
cord-328189-jpkxjn6e	132	3	50	50	CD
cord-328189-jpkxjn6e	132	4	random	random	JJ
cord-328189-jpkxjn6e	132	5	snapshots	snapshot	NNS
cord-328189-jpkxjn6e	132	6	from	from	IN
cord-328189-jpkxjn6e	132	7	the	the	DT
cord-328189-jpkxjn6e	132	8	MD	MD	NNP
cord-328189-jpkxjn6e	132	9	trajectories	trajectory	NNS
cord-328189-jpkxjn6e	132	10	of	of	IN
cord-328189-jpkxjn6e	132	11	COVID-19-ACE2	covid-19-ace2	CD
cord-328189-jpkxjn6e	132	12	,	,	,
cord-328189-jpkxjn6e	132	13	SARS-2002-ACE2	SARS-2002-ACE2	NNP
cord-328189-jpkxjn6e	132	14	,	,	,
cord-328189-jpkxjn6e	132	15	and	and	CC
cord-328189-jpkxjn6e	132	16	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	132	17	-	-	HYPH
cord-328189-jpkxjn6e	132	18	NL63-ACE2	NL63-ACE2	NNP
cord-328189-jpkxjn6e	132	19	complexes	complex	NNS
cord-328189-jpkxjn6e	132	20	.	.	.
cord-328189-jpkxjn6e	133	1	For	for	IN
cord-328189-jpkxjn6e	133	2	clarity	clarity	NN
cord-328189-jpkxjn6e	133	3	only	only	RB
cord-328189-jpkxjn6e	133	4	one	one	CD
cord-328189-jpkxjn6e	133	5	copy	copy	NN
cord-328189-jpkxjn6e	133	6	of	of	IN
cord-328189-jpkxjn6e	133	7	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	133	8	is	be	VBZ
cord-328189-jpkxjn6e	133	9	shown	show	VBN
cord-328189-jpkxjn6e	133	10	(	(	-LRB-
cord-328189-jpkxjn6e	133	11	gray	gray	JJ
cord-328189-jpkxjn6e	133	12	)	)	-RRB-
cord-328189-jpkxjn6e	133	13	,	,	,
cord-328189-jpkxjn6e	133	14	COVID-19	COVID-19	NNP
cord-328189-jpkxjn6e	133	15	,	,	,
cord-328189-jpkxjn6e	133	16	SARS-2002	SARS-2002	NNP
cord-328189-jpkxjn6e	133	17	,	,	,
cord-328189-jpkxjn6e	133	18	and	and	CC
cord-328189-jpkxjn6e	134	1	HCoV	HCoV	NNP
cord-328189-jpkxjn6e	134	2	-	-	:
cord-328189-jpkxjn6e	134	3	NL63	NL63	NNP
cord-328189-jpkxjn6e	134	4	are	be	VBP
cord-328189-jpkxjn6e	134	5	colored	color	VBN
cord-328189-jpkxjn6e	134	6	blue	blue	JJ
cord-328189-jpkxjn6e	134	7	,	,	,
cord-328189-jpkxjn6e	134	8	red	red	JJ
cord-328189-jpkxjn6e	134	9	,	,	,
cord-328189-jpkxjn6e	134	10	and	and	CC
cord-328189-jpkxjn6e	134	11	green	green	JJ
cord-328189-jpkxjn6e	134	12	,	,	,
cord-328189-jpkxjn6e	134	13	respectively	respectively	RB
cord-328189-jpkxjn6e	134	14	.	.	.
cord-328189-jpkxjn6e	135	1	Characterization	characterization	NN
cord-328189-jpkxjn6e	135	2	of	of	IN
cord-328189-jpkxjn6e	135	3	a	a	DT
cord-328189-jpkxjn6e	135	4	novel	novel	JJ
cord-328189-jpkxjn6e	135	5	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	135	6	associated	associate	VBN
cord-328189-jpkxjn6e	135	7	with	with	IN
cord-328189-jpkxjn6e	135	8	severe	severe	JJ
cord-328189-jpkxjn6e	135	9	acute	acute	JJ
cord-328189-jpkxjn6e	135	10	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	135	11	syndrome	syndrome	NN
cord-328189-jpkxjn6e	135	12	Return	return	NN
cord-328189-jpkxjn6e	135	13	of	of	IN
cord-328189-jpkxjn6e	135	14	the	the	DT
cord-328189-jpkxjn6e	135	15	Coronavirus	Coronavirus	NNP
cord-328189-jpkxjn6e	135	16	:	:	:
cord-328189-jpkxjn6e	135	17	2019-nCoV	2019-ncov	CD
cord-328189-jpkxjn6e	135	18	Coronavirus	Coronavirus	NNP
cord-328189-jpkxjn6e	135	19	pathogenesis	pathogenesis	NN
cord-328189-jpkxjn6e	135	20	and	and	CC
cord-328189-jpkxjn6e	135	21	the	the	DT
cord-328189-jpkxjn6e	135	22	emerging	emerge	VBG
cord-328189-jpkxjn6e	135	23	pathogen	pathogen	NN
cord-328189-jpkxjn6e	135	24	severe	severe	JJ
cord-328189-jpkxjn6e	135	25	acute	acute	JJ
cord-328189-jpkxjn6e	135	26	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	135	27	syndrome	syndrome	NN
cord-328189-jpkxjn6e	135	28	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	135	29	Epidemiology	epidemiology	NN
cord-328189-jpkxjn6e	135	30	and	and	CC
cord-328189-jpkxjn6e	135	31	clinical	clinical	JJ
cord-328189-jpkxjn6e	135	32	characteristics	characteristic	NNS
cord-328189-jpkxjn6e	135	33	of	of	IN
cord-328189-jpkxjn6e	135	34	human	human	JJ
cord-328189-jpkxjn6e	135	35	coronaviruses	coronaviruse	NNS
cord-328189-jpkxjn6e	135	36	OC43	OC43	NNP
cord-328189-jpkxjn6e	135	37	,	,	,
cord-328189-jpkxjn6e	135	38	229E	229e	CD
cord-328189-jpkxjn6e	135	39	,	,	,
cord-328189-jpkxjn6e	135	40	NL63	NL63	NNP
cord-328189-jpkxjn6e	135	41	,	,	,
cord-328189-jpkxjn6e	135	42	and	and	CC
cord-328189-jpkxjn6e	135	43	HKU1	HKU1	NNP
cord-328189-jpkxjn6e	135	44	:	:	:
cord-328189-jpkxjn6e	135	45	a	a	DT
cord-328189-jpkxjn6e	135	46	study	study	NN
cord-328189-jpkxjn6e	135	47	of	of	IN
cord-328189-jpkxjn6e	135	48	hospitalized	hospitalize	VBN
cord-328189-jpkxjn6e	135	49	children	child	NNS
cord-328189-jpkxjn6e	135	50	with	with	IN
cord-328189-jpkxjn6e	135	51	acute	acute	JJ
cord-328189-jpkxjn6e	135	52	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	135	53	tract	tract	NN
cord-328189-jpkxjn6e	135	54	infection	infection	NN
cord-328189-jpkxjn6e	135	55	in	in	IN
cord-328189-jpkxjn6e	135	56	Guangzhou	Guangzhou	NNP
cord-328189-jpkxjn6e	135	57	,	,	,
cord-328189-jpkxjn6e	135	58	China	China	NNP
cord-328189-jpkxjn6e	135	59	A	a	DT
cord-328189-jpkxjn6e	135	60	new	new	JJ
cord-328189-jpkxjn6e	135	61	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	135	62	associated	associate	VBN
cord-328189-jpkxjn6e	135	63	with	with	IN
cord-328189-jpkxjn6e	135	64	human	human	JJ
cord-328189-jpkxjn6e	135	65	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	135	66	disease	disease	NN
cord-328189-jpkxjn6e	135	67	in	in	IN
cord-328189-jpkxjn6e	135	68	China	China	NNP
cord-328189-jpkxjn6e	135	69	Structural	structural	JJ
cord-328189-jpkxjn6e	135	70	basis	basis	NN
cord-328189-jpkxjn6e	135	71	for	for	IN
cord-328189-jpkxjn6e	135	72	human	human	JJ
cord-328189-jpkxjn6e	135	73	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	135	74	attachment	attachment	NN
cord-328189-jpkxjn6e	135	75	to	to	IN
cord-328189-jpkxjn6e	135	76	sialic	sialic	JJ
cord-328189-jpkxjn6e	135	77	acid	acid	NN
cord-328189-jpkxjn6e	135	78	receptors	receptor	NNS
cord-328189-jpkxjn6e	136	1	A	a	DT
cord-328189-jpkxjn6e	136	2	crucial	crucial	JJ
cord-328189-jpkxjn6e	136	3	role	role	NN
cord-328189-jpkxjn6e	136	4	of	of	IN
cord-328189-jpkxjn6e	136	5	angiotensin	angiotensin	NN
cord-328189-jpkxjn6e	136	6	converting	convert	VBG
cord-328189-jpkxjn6e	136	7	enzyme	enzyme	NN
cord-328189-jpkxjn6e	136	8	2	2	CD
cord-328189-jpkxjn6e	136	9	(	(	-LRB-
cord-328189-jpkxjn6e	136	10	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	136	11	)	)	-RRB-
cord-328189-jpkxjn6e	136	12	in	in	IN
cord-328189-jpkxjn6e	136	13	SARS	SARS	NNP
cord-328189-jpkxjn6e	136	14	coronavirusinduced	coronavirusinduced	NNP
cord-328189-jpkxjn6e	136	15	lung	lung	NNP
cord-328189-jpkxjn6e	136	16	injury	injury	NN
cord-328189-jpkxjn6e	136	17	Susceptibility	Susceptibility	NNP
cord-328189-jpkxjn6e	136	18	to	to	IN
cord-328189-jpkxjn6e	136	19	SARS	SARS	NNP
cord-328189-jpkxjn6e	136	20	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	136	21	S	S	NNP
cord-328189-jpkxjn6e	136	22	protein	protein	NN
cord-328189-jpkxjn6e	136	23	-	-	HYPH
cord-328189-jpkxjn6e	136	24	driven	drive	VBN
cord-328189-jpkxjn6e	136	25	infection	infection	NN
cord-328189-jpkxjn6e	136	26	correlates	correlate	VBZ
cord-328189-jpkxjn6e	136	27	with	with	IN
cord-328189-jpkxjn6e	136	28	expression	expression	NN
cord-328189-jpkxjn6e	136	29	of	of	IN
cord-328189-jpkxjn6e	136	30	angiotensin	angiotensin	NN
cord-328189-jpkxjn6e	136	31	converting	convert	VBG
cord-328189-jpkxjn6e	136	32	enzyme	enzyme	NN
cord-328189-jpkxjn6e	136	33	2	2	CD
cord-328189-jpkxjn6e	136	34	and	and	CC
cord-328189-jpkxjn6e	136	35	infection	infection	NN
cord-328189-jpkxjn6e	136	36	can	can	MD
cord-328189-jpkxjn6e	136	37	be	be	VB
cord-328189-jpkxjn6e	136	38	blocked	block	VBN
cord-328189-jpkxjn6e	136	39	by	by	IN
cord-328189-jpkxjn6e	136	40	soluble	soluble	JJ
cord-328189-jpkxjn6e	136	41	receptor	receptor	NN
cord-328189-jpkxjn6e	136	42	Exogenous	Exogenous	NNP
cord-328189-jpkxjn6e	136	43	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	136	44	expression	expression	NN
cord-328189-jpkxjn6e	137	1	allows	allow	VBZ
cord-328189-jpkxjn6e	137	2	refractory	refractory	JJ
cord-328189-jpkxjn6e	137	3	cell	cell	NN
cord-328189-jpkxjn6e	137	4	lines	line	NNS
cord-328189-jpkxjn6e	137	5	to	to	TO
cord-328189-jpkxjn6e	137	6	support	support	VB
cord-328189-jpkxjn6e	137	7	severe	severe	JJ
cord-328189-jpkxjn6e	137	8	acute	acute	JJ
cord-328189-jpkxjn6e	137	9	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	137	10	syndrome	syndrome	NN
cord-328189-jpkxjn6e	137	11	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	137	12	replication	replication	NN
cord-328189-jpkxjn6e	137	13	Tissue	tissue	NN
cord-328189-jpkxjn6e	137	14	distribution	distribution	NN
cord-328189-jpkxjn6e	137	15	of	of	IN
cord-328189-jpkxjn6e	137	16	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	137	17	protein	protein	NN
cord-328189-jpkxjn6e	137	18	,	,	,
cord-328189-jpkxjn6e	137	19	the	the	DT
cord-328189-jpkxjn6e	137	20	functional	functional	JJ
cord-328189-jpkxjn6e	137	21	receptor	receptor	NN
cord-328189-jpkxjn6e	137	22	for	for	IN
cord-328189-jpkxjn6e	137	23	SARS	SARS	NNP
cord-328189-jpkxjn6e	137	24	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	137	25	.	.	.
cord-328189-jpkxjn6e	138	1	A	a	DT
cord-328189-jpkxjn6e	138	2	first	first	JJ
cord-328189-jpkxjn6e	138	3	step	step	NN
cord-328189-jpkxjn6e	138	4	in	in	IN
cord-328189-jpkxjn6e	138	5	understanding	understand	VBG
cord-328189-jpkxjn6e	138	6	SARS	SARS	NNP
cord-328189-jpkxjn6e	138	7	pathogenesis	pathogenesis	NN
cord-328189-jpkxjn6e	138	8	Receptor	Receptor	NNP
cord-328189-jpkxjn6e	138	9	recognition	recognition	NN
cord-328189-jpkxjn6e	138	10	by	by	IN
cord-328189-jpkxjn6e	138	11	novel	novel	JJ
cord-328189-jpkxjn6e	138	12	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	138	13	from	from	IN
cord-328189-jpkxjn6e	138	14	Wuhan	Wuhan	NNP
cord-328189-jpkxjn6e	138	15	:	:	:
cord-328189-jpkxjn6e	139	1	An	an	DT
cord-328189-jpkxjn6e	139	2	analysis	analysis	NN
cord-328189-jpkxjn6e	139	3	based	base	VBN
cord-328189-jpkxjn6e	139	4	on	on	IN
cord-328189-jpkxjn6e	139	5	decade	decade	NN
cord-328189-jpkxjn6e	139	6	-	-	HYPH
cord-328189-jpkxjn6e	139	7	long	long	JJ
cord-328189-jpkxjn6e	139	8	structural	structural	JJ
cord-328189-jpkxjn6e	139	9	studies	study	NNS
cord-328189-jpkxjn6e	139	10	of	of	IN
cord-328189-jpkxjn6e	139	11	SARS	SARS	NNP
cord-328189-jpkxjn6e	139	12	Human	Human	NNP
cord-328189-jpkxjn6e	139	13	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	139	14	NL63	NL63	NNP
cord-328189-jpkxjn6e	139	15	employs	employ	VBZ
cord-328189-jpkxjn6e	139	16	the	the	DT
cord-328189-jpkxjn6e	139	17	severe	severe	JJ
cord-328189-jpkxjn6e	139	18	acute	acute	JJ
cord-328189-jpkxjn6e	139	19	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	139	20	syndrome	syndrome	NN
cord-328189-jpkxjn6e	139	21	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	139	22	receptor	receptor	NN
cord-328189-jpkxjn6e	139	23	for	for	IN
cord-328189-jpkxjn6e	139	24	cellular	cellular	JJ
cord-328189-jpkxjn6e	139	25	entry	entry	NN
cord-328189-jpkxjn6e	140	1	The	the	DT
cord-328189-jpkxjn6e	140	2	S	S	NNP
cord-328189-jpkxjn6e	140	3	proteins	protein	NNS
cord-328189-jpkxjn6e	140	4	of	of	IN
cord-328189-jpkxjn6e	140	5	human	human	JJ
cord-328189-jpkxjn6e	140	6	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	140	7	NL63	NL63	NNP
cord-328189-jpkxjn6e	140	8	and	and	CC
cord-328189-jpkxjn6e	140	9	severe	severe	JJ
cord-328189-jpkxjn6e	140	10	acute	acute	JJ
cord-328189-jpkxjn6e	140	11	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	140	12	syndrome	syndrome	NN
cord-328189-jpkxjn6e	140	13	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	140	14	bind	bind	VBP
cord-328189-jpkxjn6e	140	15	overlapping	overlap	VBG
cord-328189-jpkxjn6e	140	16	regions	region	NNS
cord-328189-jpkxjn6e	140	17	of	of	IN
cord-328189-jpkxjn6e	140	18	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	140	19	Structure	Structure	NNP
cord-328189-jpkxjn6e	140	20	of	of	IN
cord-328189-jpkxjn6e	140	21	MERS	MERS	NNP
cord-328189-jpkxjn6e	140	22	-	-	HYPH
cord-328189-jpkxjn6e	140	23	CoV	CoV	NNP
cord-328189-jpkxjn6e	140	24	spike	spike	NN
cord-328189-jpkxjn6e	140	25	receptor	receptor	NN
cord-328189-jpkxjn6e	140	26	-	-	HYPH
cord-328189-jpkxjn6e	140	27	binding	bind	VBG
cord-328189-jpkxjn6e	140	28	domain	domain	NN
cord-328189-jpkxjn6e	140	29	complexed	complexe	VBN
cord-328189-jpkxjn6e	140	30	with	with	IN
cord-328189-jpkxjn6e	140	31	human	human	JJ
cord-328189-jpkxjn6e	140	32	receptor	receptor	NN
cord-328189-jpkxjn6e	140	33	DPP4	DPP4	NNP
cord-328189-jpkxjn6e	140	34	TM	TM	NNP
cord-328189-jpkxjn6e	140	35	-	-	HYPH
cord-328189-jpkxjn6e	140	36	align	align	NNP
cord-328189-jpkxjn6e	140	37	:	:	:
cord-328189-jpkxjn6e	140	38	a	a	DT
cord-328189-jpkxjn6e	140	39	protein	protein	NN
cord-328189-jpkxjn6e	140	40	structure	structure	NN
cord-328189-jpkxjn6e	140	41	alignment	alignment	NN
cord-328189-jpkxjn6e	140	42	algorithm	algorithm	NN
cord-328189-jpkxjn6e	140	43	based	base	VBN
cord-328189-jpkxjn6e	140	44	on	on	IN
cord-328189-jpkxjn6e	140	45	the	the	DT
cord-328189-jpkxjn6e	140	46	TM	TM	NNP
cord-328189-jpkxjn6e	140	47	-	-	HYPH
cord-328189-jpkxjn6e	140	48	score	score	NN
cord-328189-jpkxjn6e	140	49	Optimized	Optimized	NNP
cord-328189-jpkxjn6e	140	50	atomic	atomic	JJ
cord-328189-jpkxjn6e	140	51	statistical	statistical	JJ
cord-328189-jpkxjn6e	140	52	potentials	potential	NNS
cord-328189-jpkxjn6e	140	53	:	:	:
cord-328189-jpkxjn6e	140	54	assessment	assessment	NN
cord-328189-jpkxjn6e	140	55	of	of	IN
cord-328189-jpkxjn6e	140	56	protein	protein	NN
cord-328189-jpkxjn6e	140	57	interfaces	interface	NNS
cord-328189-jpkxjn6e	140	58	and	and	CC
cord-328189-jpkxjn6e	140	59	loops	loop	VBZ
cord-328189-jpkxjn6e	140	60	Structural	structural	JJ
cord-328189-jpkxjn6e	140	61	basis	basis	NN
cord-328189-jpkxjn6e	140	62	for	for	IN
cord-328189-jpkxjn6e	140	63	the	the	DT
cord-328189-jpkxjn6e	140	64	recognition	recognition	NN
cord-328189-jpkxjn6e	140	65	of	of	IN
cord-328189-jpkxjn6e	140	66	the	the	DT
cord-328189-jpkxjn6e	140	67	2019-nCoV	2019-ncov	CD
cord-328189-jpkxjn6e	140	68	by	by	IN
cord-328189-jpkxjn6e	140	69	human	human	JJ
cord-328189-jpkxjn6e	140	70	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	140	71	.	.	.
cord-328189-jpkxjn6e	141	1	bioRxiv	biorxiv	RB
cord-328189-jpkxjn6e	142	1	Computational	computational	JJ
cord-328189-jpkxjn6e	142	2	characterization	characterization	NN
cord-328189-jpkxjn6e	142	3	and	and	CC
cord-328189-jpkxjn6e	142	4	design	design	NN
cord-328189-jpkxjn6e	142	5	of	of	IN
cord-328189-jpkxjn6e	142	6	SARS	SARS	NNP
cord-328189-jpkxjn6e	142	7	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	142	8	receptor	receptor	NN
cord-328189-jpkxjn6e	142	9	recognition	recognition	NN
cord-328189-jpkxjn6e	142	10	and	and	CC
cord-328189-jpkxjn6e	142	11	antibody	antibody	NN
cord-328189-jpkxjn6e	142	12	neutralization	neutralization	NN
cord-328189-jpkxjn6e	142	13	Receptor	receptor	NN
cord-328189-jpkxjn6e	142	14	and	and	CC
cord-328189-jpkxjn6e	142	15	viral	viral	JJ
cord-328189-jpkxjn6e	142	16	determinants	determinant	NNS
cord-328189-jpkxjn6e	142	17	of	of	IN
cord-328189-jpkxjn6e	142	18	SARS	SARS	NNP
cord-328189-jpkxjn6e	142	19	-	-	HYPH
cord-328189-jpkxjn6e	142	20	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	142	21	adaptation	adaptation	NN
cord-328189-jpkxjn6e	142	22	to	to	IN
cord-328189-jpkxjn6e	142	23	human	human	JJ
cord-328189-jpkxjn6e	142	24	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	142	25	Potent	Potent	NNP
cord-328189-jpkxjn6e	142	26	binding	binding	NN
cord-328189-jpkxjn6e	142	27	of	of	IN
cord-328189-jpkxjn6e	142	28	2019	2019	CD
cord-328189-jpkxjn6e	142	29	novel	novel	JJ
cord-328189-jpkxjn6e	142	30	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	142	31	spike	spike	NN
cord-328189-jpkxjn6e	142	32	protein	protein	NN
cord-328189-jpkxjn6e	142	33	by	by	IN
cord-328189-jpkxjn6e	142	34	a	a	DT
cord-328189-jpkxjn6e	142	35	SARS	SARS	NNP
cord-328189-jpkxjn6e	142	36	coronavirusspecific	coronavirusspecific	NNP
cord-328189-jpkxjn6e	142	37	human	human	JJ
cord-328189-jpkxjn6e	142	38	monoclonal	monoclonal	NNP
cord-328189-jpkxjn6e	142	39	antibody	antibody	NN
cord-328189-jpkxjn6e	142	40	Crystal	Crystal	NNP
cord-328189-jpkxjn6e	142	41	structure	structure	NN
cord-328189-jpkxjn6e	142	42	of	of	IN
cord-328189-jpkxjn6e	142	43	NL63	NL63	NNP
cord-328189-jpkxjn6e	142	44	respiratory	respiratory	JJ
cord-328189-jpkxjn6e	142	45	coronavirus	coronavirus	NN
cord-328189-jpkxjn6e	142	46	receptor	receptor	NN
cord-328189-jpkxjn6e	142	47	-	-	HYPH
cord-328189-jpkxjn6e	142	48	binding	bind	VBG
cord-328189-jpkxjn6e	142	49	domain	domain	NN
cord-328189-jpkxjn6e	142	50	complexed	complexe	VBN
cord-328189-jpkxjn6e	142	51	with	with	IN
cord-328189-jpkxjn6e	142	52	its	-PRON-	PRP$
cord-328189-jpkxjn6e	142	53	human	human	JJ
cord-328189-jpkxjn6e	142	54	receptor	receptor	NN
cord-328189-jpkxjn6e	142	55	Structure	Structure	NNP
cord-328189-jpkxjn6e	142	56	,	,	,
cord-328189-jpkxjn6e	142	57	function	function	NN
cord-328189-jpkxjn6e	142	58	and	and	CC
cord-328189-jpkxjn6e	142	59	antigenicity	antigenicity	NN
cord-328189-jpkxjn6e	142	60	of	of	IN
cord-328189-jpkxjn6e	142	61	the	the	DT
cord-328189-jpkxjn6e	142	62	SARS	SARS	NNP
cord-328189-jpkxjn6e	142	63	-	-	HYPH
cord-328189-jpkxjn6e	142	64	CoV-2	CoV-2	NNP
cord-328189-jpkxjn6e	142	65	spike	spike	NN
cord-328189-jpkxjn6e	142	66	glycoprotein	glycoprotein	NN
cord-328189-jpkxjn6e	142	67	.	.	.
cord-328189-jpkxjn6e	143	1	bioRxiv	biorxiv	DT
cord-328189-jpkxjn6e	143	2	Cryo	Cryo	NNP
cord-328189-jpkxjn6e	143	3	-	-	HYPH
cord-328189-jpkxjn6e	143	4	EM	EM	NNP
cord-328189-jpkxjn6e	143	5	structure	structure	NN
cord-328189-jpkxjn6e	143	6	of	of	IN
cord-328189-jpkxjn6e	143	7	the	the	DT
cord-328189-jpkxjn6e	143	8	2019-nCoV	2019-ncov	CD
cord-328189-jpkxjn6e	143	9	spike	spike	NN
cord-328189-jpkxjn6e	143	10	in	in	IN
cord-328189-jpkxjn6e	143	11	the	the	DT
cord-328189-jpkxjn6e	143	12	prefusion	prefusion	NN
cord-328189-jpkxjn6e	143	13	conformation	conformation	NN
cord-328189-jpkxjn6e	144	1	A	a	DT
cord-328189-jpkxjn6e	144	2	hexapeptide	hexapeptide	NN
cord-328189-jpkxjn6e	144	3	of	of	IN
cord-328189-jpkxjn6e	144	4	the	the	DT
cord-328189-jpkxjn6e	144	5	receptorbinding	receptorbinding	NN
cord-328189-jpkxjn6e	144	6	domain	domain	NN
cord-328189-jpkxjn6e	144	7	of	of	IN
cord-328189-jpkxjn6e	144	8	SARS	SARS	NNP
cord-328189-jpkxjn6e	144	9	corona	corona	NNP
cord-328189-jpkxjn6e	144	10	virus	virus	NN
cord-328189-jpkxjn6e	144	11	spike	spike	NN
cord-328189-jpkxjn6e	144	12	protein	protein	NN
cord-328189-jpkxjn6e	144	13	blocks	block	VBZ
cord-328189-jpkxjn6e	144	14	viral	viral	JJ
cord-328189-jpkxjn6e	144	15	entry	entry	NN
cord-328189-jpkxjn6e	144	16	into	into	IN
cord-328189-jpkxjn6e	144	17	host	host	NN
cord-328189-jpkxjn6e	144	18	cells	cell	NNS
cord-328189-jpkxjn6e	144	19	via	via	IN
cord-328189-jpkxjn6e	144	20	the	the	DT
cord-328189-jpkxjn6e	144	21	human	human	JJ
cord-328189-jpkxjn6e	144	22	receptor	receptor	NN
cord-328189-jpkxjn6e	144	23	ACE2	ACE2	NNP
cord-328189-jpkxjn6e	145	1	The	the	DT
cord-328189-jpkxjn6e	145	2	spike	spike	NN
cord-328189-jpkxjn6e	145	3	protein	protein	NN
cord-328189-jpkxjn6e	145	4	of	of	IN
cord-328189-jpkxjn6e	145	5	SARS	SARS	NNP
cord-328189-jpkxjn6e	145	6	-	-	HYPH
cord-328189-jpkxjn6e	145	7	CoV	CoV	NNP
cord-328189-jpkxjn6e	145	8	--	--	:
cord-328189-jpkxjn6e	145	9	a	a	DT
cord-328189-jpkxjn6e	145	10	target	target	NN
cord-328189-jpkxjn6e	145	11	for	for	IN
cord-328189-jpkxjn6e	145	12	vaccine	vaccine	NN
cord-328189-jpkxjn6e	145	13	and	and	CC
cord-328189-jpkxjn6e	145	14	therapeutic	therapeutic	JJ
cord-328189-jpkxjn6e	145	15	development	development	NN
cord-328189-jpkxjn6e	146	1	The	the	DT
cord-328189-jpkxjn6e	146	2	indistinguishability	indistinguishability	NN
cord-328189-jpkxjn6e	146	3	of	of	IN
cord-328189-jpkxjn6e	146	4	epitopes	epitope	NNS
cord-328189-jpkxjn6e	146	5	from	from	IN
cord-328189-jpkxjn6e	146	6	protein	protein	NN
cord-328189-jpkxjn6e	146	7	surface	surface	NN
cord-328189-jpkxjn6e	146	8	is	be	VBZ
cord-328189-jpkxjn6e	146	9	explained	explain	VBN
cord-328189-jpkxjn6e	146	10	by	by	IN
cord-328189-jpkxjn6e	146	11	the	the	DT
cord-328189-jpkxjn6e	146	12	distinct	distinct	JJ
cord-328189-jpkxjn6e	146	13	binding	binding	NN
cord-328189-jpkxjn6e	146	14	preferences	preference	NNS
cord-328189-jpkxjn6e	146	15	of	of	IN
cord-328189-jpkxjn6e	146	16	each	each	DT
cord-328189-jpkxjn6e	146	17	of	of	IN
cord-328189-jpkxjn6e	146	18	the	the	DT
cord-328189-jpkxjn6e	146	19	six	six	CD
cord-328189-jpkxjn6e	146	20	antigen	antigen	NN
cord-328189-jpkxjn6e	146	21	-	-	HYPH
cord-328189-jpkxjn6e	146	22	binding	bind	VBG
cord-328189-jpkxjn6e	146	23	loops	loop	NNS
cord-328189-jpkxjn6e	146	24	Comparative	comparative	JJ
cord-328189-jpkxjn6e	146	25	protein	protein	NN
cord-328189-jpkxjn6e	146	26	structure	structure	NN
cord-328189-jpkxjn6e	146	27	modeling	modeling	NN
cord-328189-jpkxjn6e	146	28	using	use	VBG
cord-328189-jpkxjn6e	146	29	MODELLER	MODELLER	NNP
cord-328189-jpkxjn6e	146	30	GROMACS	GROMACS	NNP
cord-328189-jpkxjn6e	146	31	4.5	4.5	CD
cord-328189-jpkxjn6e	146	32	:	:	:
cord-328189-jpkxjn6e	146	33	a	a	DT
cord-328189-jpkxjn6e	146	34	high	high	JJ
cord-328189-jpkxjn6e	146	35	-	-	HYPH
cord-328189-jpkxjn6e	146	36	throughput	throughput	NN
cord-328189-jpkxjn6e	146	37	and	and	CC
cord-328189-jpkxjn6e	146	38	highly	highly	RB
cord-328189-jpkxjn6e	146	39	parallel	parallel	JJ
cord-328189-jpkxjn6e	146	40	open	open	JJ
cord-328189-jpkxjn6e	146	41	source	source	NN
cord-328189-jpkxjn6e	146	42	molecular	molecular	JJ
cord-328189-jpkxjn6e	146	43	simulation	simulation	NN
cord-328189-jpkxjn6e	146	44	toolkit	toolkit	NN
cord-328189-jpkxjn6e	146	45	CHARMM36	CHARMM36	NNP
cord-328189-jpkxjn6e	146	46	m	m	NN
cord-328189-jpkxjn6e	146	47	:	:	:
cord-328189-jpkxjn6e	146	48	an	an	DT
cord-328189-jpkxjn6e	146	49	improved	improve	VBN
cord-328189-jpkxjn6e	146	50	force	force	NN
cord-328189-jpkxjn6e	146	51	field	field	NN
cord-328189-jpkxjn6e	146	52	for	for	IN
cord-328189-jpkxjn6e	146	53	folded	folded	JJ
cord-328189-jpkxjn6e	146	54	and	and	CC
cord-328189-jpkxjn6e	146	55	intrinsically	intrinsically	RB
cord-328189-jpkxjn6e	146	56	disordered	disordered	JJ
cord-328189-jpkxjn6e	146	57	proteins	protein	NNS
cord-328189-jpkxjn6e	146	58	Acknowledgments	acknowledgment	NNS
cord-328189-jpkxjn6e	146	59	.	.	.
cord-328189-jpkxjn6e	147	1	The	the	DT
cord-328189-jpkxjn6e	147	2	authors	author	NNS
cord-328189-jpkxjn6e	147	3	gratefully	gratefully	RB
cord-328189-jpkxjn6e	147	4	acknowledge	acknowledge	VBP
cord-328189-jpkxjn6e	147	5	Barak	Barak	NNP
cord-328189-jpkxjn6e	147	6	Raveh	Raveh	NNP
cord-328189-jpkxjn6e	147	7	for	for	IN
cord-328189-jpkxjn6e	147	8	useful	useful	JJ
cord-328189-jpkxjn6e	147	9	suggestions	suggestion	NNS
cord-328189-jpkxjn6e	147	10	.	.	.
cord-328189-jpkxjn6e	147	11	 	 	_SP
cord-328189-jpkxjn6e	148	1	Tables	table	NNS
cord-328189-jpkxjn6e	149	1	S1-S2Movie	S1-S2Movie	NNP
cord-328189-jpkxjn6e	149	2	S1References	s1reference	NNS
cord-328189-jpkxjn6e	149	3	(	(	-LRB-
cord-328189-jpkxjn6e	149	4	27	27	CD
cord-328189-jpkxjn6e	149	5	)	)	-RRB-
cord-328189-jpkxjn6e	149	6	(	(	-LRB-
cord-328189-jpkxjn6e	149	7	28	28	CD
cord-328189-jpkxjn6e	149	8	)	)	-RRB-
cord-328189-jpkxjn6e	149	9	(	(	-LRB-
cord-328189-jpkxjn6e	149	10	29	29	CD
cord-328189-jpkxjn6e	149	11	)	)	-RRB-
cord-328189-jpkxjn6e	149	12	 	 	_SP
cord-328189-jpkxjn6e	149	13	Residue	Residue	NNP
cord-328189-jpkxjn6e	149	14	 	 	_SP