id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309563-3cuzmsll	Duprex, W. Paul	Gain-of-function experiments: time for a real debate	2014-12-08		.txt	text/plain	6574	278	44	Recent studies, particularly those on influenza viruses, have led to renewed attention on DURC, as there is an ongoing debate over whether the benefits of gain-of-function (GOF) experiments that result in an increase in the transmission and/or pathogenicity of potential pandemic pathogens (PPPs) are outweighed by concerns over biosecurity and biosafety. Recent studies, particularly those on influenza viruses, have led to renewed attention on DURC, as there is an ongoing debate over whether the benefits of gain-of-function (GOF) experiments that result in an increase in the transmission and/or pathogenicity of potential pandemic pathogens (PPPs) are outweighed by concerns over biosecurity and biosafety. In this Viewpoint article, proponents and opponents of GOF experiments discuss the benefits and risks associated with these studies, as well as the implications of the current debate for the scientific community and the general public, and suggest how the current discussion should move forward.	./cache/cord-309563-3cuzmsll.txt	./txt/cord-309563-3cuzmsll.txt