id sid tid token lemma pos cord-251986-ajlpb9li 1 1 key key NN cord-251986-ajlpb9li 1 2 : : : cord-251986-ajlpb9li 2 1 cord-251986-ajlpb9li cord-251986-ajlpb9li NNP cord-251986-ajlpb9li 2 2 authors author NNS cord-251986-ajlpb9li 2 3 : : : cord-251986-ajlpb9li 2 4 Li Li NNP cord-251986-ajlpb9li 2 5 , , , cord-251986-ajlpb9li 2 6 Yan‐Chao Yan‐Chao NNP cord-251986-ajlpb9li 2 7 ; ; : cord-251986-ajlpb9li 2 8 Bai Bai NNP cord-251986-ajlpb9li 2 9 , , , cord-251986-ajlpb9li 2 10 Wan‐Zhu Wan‐Zhu NNP cord-251986-ajlpb9li 2 11 ; ; : cord-251986-ajlpb9li 2 12 Hashikawa Hashikawa NNP cord-251986-ajlpb9li 2 13 , , , cord-251986-ajlpb9li 2 14 Tsutomu Tsutomu NNP cord-251986-ajlpb9li 2 15 title title NN cord-251986-ajlpb9li 2 16 : : : cord-251986-ajlpb9li 2 17 The the DT cord-251986-ajlpb9li 2 18 neuroinvasive neuroinvasive JJ cord-251986-ajlpb9li 2 19 potential potential NN cord-251986-ajlpb9li 2 20 of of IN cord-251986-ajlpb9li 2 21 SARS‐CoV2 SARS‐CoV2 NNP cord-251986-ajlpb9li 2 22 may may MD cord-251986-ajlpb9li 2 23 play play VB cord-251986-ajlpb9li 2 24 a a DT cord-251986-ajlpb9li 2 25 role role NN cord-251986-ajlpb9li 2 26 in in IN cord-251986-ajlpb9li 2 27 the the DT cord-251986-ajlpb9li 2 28 respiratory respiratory JJ cord-251986-ajlpb9li 2 29 failure failure NN cord-251986-ajlpb9li 2 30 of of IN cord-251986-ajlpb9li 2 31 COVID‐19 covid‐19 NN cord-251986-ajlpb9li 2 32 patients patient NNS cord-251986-ajlpb9li 2 33 date date NN cord-251986-ajlpb9li 2 34 : : : cord-251986-ajlpb9li 2 35 2020 2020 CD cord-251986-ajlpb9li 2 36 - - HYPH cord-251986-ajlpb9li 2 37 03 03 CD cord-251986-ajlpb9li 2 38 - - HYPH cord-251986-ajlpb9li 2 39 11 11 CD cord-251986-ajlpb9li 2 40 journal journal NN cord-251986-ajlpb9li 2 41 : : : cord-251986-ajlpb9li 3 1 J J NNP cord-251986-ajlpb9li 3 2 Med Med NNP cord-251986-ajlpb9li 3 3 Virol Virol NNP cord-251986-ajlpb9li 3 4 DOI doi NN cord-251986-ajlpb9li 3 5 : : : cord-251986-ajlpb9li 4 1 10.1002/ 10.1002/ LS cord-251986-ajlpb9li 5 1 jmv.25728 jmv.25728 NNP cord-251986-ajlpb9li 6 1 sha sha NNP cord-251986-ajlpb9li 6 2 : : : cord-251986-ajlpb9li 7 1 ba139493dfc91d8e847d162613747f40950add89 ba139493dfc91d8e847d162613747f40950add89 NNP cord-251986-ajlpb9li 7 2 doc_id doc_id NNP cord-251986-ajlpb9li 7 3 : : : cord-251986-ajlpb9li 7 4 251986 251986 CD cord-251986-ajlpb9li 7 5 cord_uid cord_uid NNS cord-251986-ajlpb9li 7 6 : : : cord-251986-ajlpb9li 8 1 ajlpb9li ajlpb9li JJ cord-251986-ajlpb9li 9 1 Following follow VBG cord-251986-ajlpb9li 9 2 the the DT cord-251986-ajlpb9li 9 3 severe severe JJ cord-251986-ajlpb9li 9 4 acute acute JJ cord-251986-ajlpb9li 9 5 respiratory respiratory JJ cord-251986-ajlpb9li 9 6 syndrome syndrome NN cord-251986-ajlpb9li 9 7 coronavirus coronavirus NN cord-251986-ajlpb9li 9 8 ( ( -LRB- cord-251986-ajlpb9li 9 9 SARS‐CoV SARS‐CoV NNP cord-251986-ajlpb9li 9 10 ) ) -RRB- cord-251986-ajlpb9li 9 11 and and CC cord-251986-ajlpb9li 9 12 Middle Middle NNP cord-251986-ajlpb9li 9 13 East East NNP cord-251986-ajlpb9li 9 14 respiratory respiratory JJ cord-251986-ajlpb9li 9 15 syndrome syndrome NN cord-251986-ajlpb9li 9 16 coronavirus coronavirus NN cord-251986-ajlpb9li 9 17 ( ( -LRB- cord-251986-ajlpb9li 9 18 MERS‐CoV MERS‐CoV NNP cord-251986-ajlpb9li 9 19 ) ) -RRB- cord-251986-ajlpb9li 9 20 , , , cord-251986-ajlpb9li 9 21 another another DT cord-251986-ajlpb9li 9 22 highly highly RB cord-251986-ajlpb9li 9 23 pathogenic pathogenic JJ cord-251986-ajlpb9li 9 24 coronavirus coronavirus NN cord-251986-ajlpb9li 9 25 named name VBN cord-251986-ajlpb9li 9 26 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-251986-ajlpb9li 9 27 ( ( -LRB- cord-251986-ajlpb9li 9 28 previously previously RB cord-251986-ajlpb9li 9 29 known know VBN cord-251986-ajlpb9li 9 30 as as IN cord-251986-ajlpb9li 9 31 2019‐nCoV 2019‐ncov CD cord-251986-ajlpb9li 9 32 ) ) -RRB- cord-251986-ajlpb9li 9 33 emerged emerge VBD cord-251986-ajlpb9li 9 34 in in IN cord-251986-ajlpb9li 9 35 December December NNP cord-251986-ajlpb9li 9 36 2019 2019 CD cord-251986-ajlpb9li 9 37 in in IN cord-251986-ajlpb9li 9 38 Wuhan Wuhan NNP cord-251986-ajlpb9li 9 39 , , , cord-251986-ajlpb9li 9 40 China China NNP cord-251986-ajlpb9li 9 41 , , , cord-251986-ajlpb9li 9 42 and and CC cord-251986-ajlpb9li 9 43 rapidly rapidly RB cord-251986-ajlpb9li 9 44 spreads spread VBZ cord-251986-ajlpb9li 9 45 around around IN cord-251986-ajlpb9li 9 46 the the DT cord-251986-ajlpb9li 9 47 world world NN cord-251986-ajlpb9li 9 48 . . . cord-251986-ajlpb9li 10 1 This this DT cord-251986-ajlpb9li 10 2 virus virus NN cord-251986-ajlpb9li 10 3 shares share VBZ cord-251986-ajlpb9li 10 4 highly highly RB cord-251986-ajlpb9li 10 5 homological homological JJ cord-251986-ajlpb9li 10 6 sequence sequence NN cord-251986-ajlpb9li 10 7 with with IN cord-251986-ajlpb9li 10 8 SARS‐CoV SARS‐CoV NNP cord-251986-ajlpb9li 10 9 , , , cord-251986-ajlpb9li 10 10 and and CC cord-251986-ajlpb9li 10 11 causes cause VBZ cord-251986-ajlpb9li 10 12 acute acute JJ cord-251986-ajlpb9li 10 13 , , , cord-251986-ajlpb9li 10 14 highly highly RB cord-251986-ajlpb9li 10 15 lethal lethal JJ cord-251986-ajlpb9li 10 16 pneumonia pneumonia NN cord-251986-ajlpb9li 10 17 coronavirus coronavirus NN cord-251986-ajlpb9li 10 18 disease disease NN cord-251986-ajlpb9li 10 19 2019 2019 CD cord-251986-ajlpb9li 11 1 ( ( -LRB- cord-251986-ajlpb9li 11 2 COVID‐19 COVID‐19 NNP cord-251986-ajlpb9li 11 3 ) ) -RRB- cord-251986-ajlpb9li 11 4 with with IN cord-251986-ajlpb9li 11 5 clinical clinical JJ cord-251986-ajlpb9li 11 6 symptoms symptom NNS cord-251986-ajlpb9li 11 7 similar similar JJ cord-251986-ajlpb9li 11 8 to to IN cord-251986-ajlpb9li 11 9 those those DT cord-251986-ajlpb9li 11 10 reported report VBN cord-251986-ajlpb9li 11 11 for for IN cord-251986-ajlpb9li 11 12 SARS‐CoV sars‐cov NN cord-251986-ajlpb9li 11 13 and and CC cord-251986-ajlpb9li 11 14 MERS‐CoV. MERS‐CoV. NNP cord-251986-ajlpb9li 12 1 The the DT cord-251986-ajlpb9li 12 2 most most RBS cord-251986-ajlpb9li 12 3 characteristic characteristic JJ cord-251986-ajlpb9li 12 4 symptom symptom NN cord-251986-ajlpb9li 12 5 of of IN cord-251986-ajlpb9li 12 6 patients patient NNS cord-251986-ajlpb9li 12 7 with with IN cord-251986-ajlpb9li 12 8 COVID‐19 COVID‐19 NNP cord-251986-ajlpb9li 12 9 is be VBZ cord-251986-ajlpb9li 12 10 respiratory respiratory JJ cord-251986-ajlpb9li 12 11 distress distress NN cord-251986-ajlpb9li 12 12 , , , cord-251986-ajlpb9li 12 13 and and CC cord-251986-ajlpb9li 12 14 most most JJS cord-251986-ajlpb9li 12 15 of of IN cord-251986-ajlpb9li 12 16 the the DT cord-251986-ajlpb9li 12 17 patients patient NNS cord-251986-ajlpb9li 12 18 admitted admit VBN cord-251986-ajlpb9li 12 19 to to IN cord-251986-ajlpb9li 12 20 the the DT cord-251986-ajlpb9li 12 21 intensive intensive JJ cord-251986-ajlpb9li 12 22 care care NN cord-251986-ajlpb9li 12 23 could could MD cord-251986-ajlpb9li 12 24 not not RB cord-251986-ajlpb9li 12 25 breathe breathe VB cord-251986-ajlpb9li 12 26 spontaneously spontaneously RB cord-251986-ajlpb9li 12 27 . . . cord-251986-ajlpb9li 13 1 Additionally additionally RB cord-251986-ajlpb9li 13 2 , , , cord-251986-ajlpb9li 13 3 some some DT cord-251986-ajlpb9li 13 4 patients patient NNS cord-251986-ajlpb9li 13 5 with with IN cord-251986-ajlpb9li 13 6 COVID‐19 COVID‐19 NNP cord-251986-ajlpb9li 13 7 also also RB cord-251986-ajlpb9li 13 8 showed show VBD cord-251986-ajlpb9li 13 9 neurologic neurologic JJ cord-251986-ajlpb9li 13 10 signs sign NNS cord-251986-ajlpb9li 13 11 , , , cord-251986-ajlpb9li 13 12 such such JJ cord-251986-ajlpb9li 13 13 as as IN cord-251986-ajlpb9li 13 14 headache headache NN cord-251986-ajlpb9li 13 15 , , , cord-251986-ajlpb9li 13 16 nausea nausea NN cord-251986-ajlpb9li 13 17 , , , cord-251986-ajlpb9li 13 18 and and CC cord-251986-ajlpb9li 13 19 vomiting vomit VBG cord-251986-ajlpb9li 13 20 . . . cord-251986-ajlpb9li 14 1 Increasing increase VBG cord-251986-ajlpb9li 14 2 evidence evidence NN cord-251986-ajlpb9li 14 3 shows show VBZ cord-251986-ajlpb9li 14 4 that that IN cord-251986-ajlpb9li 14 5 coronaviruses coronaviruse NNS cord-251986-ajlpb9li 14 6 are be VBP cord-251986-ajlpb9li 14 7 not not RB cord-251986-ajlpb9li 14 8 always always RB cord-251986-ajlpb9li 14 9 confined confine VBN cord-251986-ajlpb9li 14 10 to to IN cord-251986-ajlpb9li 14 11 the the DT cord-251986-ajlpb9li 14 12 respiratory respiratory JJ cord-251986-ajlpb9li 14 13 tract tract NN cord-251986-ajlpb9li 14 14 and and CC cord-251986-ajlpb9li 14 15 that that IN cord-251986-ajlpb9li 14 16 they -PRON- PRP cord-251986-ajlpb9li 14 17 may may MD cord-251986-ajlpb9li 14 18 also also RB cord-251986-ajlpb9li 14 19 invade invade VB cord-251986-ajlpb9li 14 20 the the DT cord-251986-ajlpb9li 14 21 central central JJ cord-251986-ajlpb9li 14 22 nervous nervous JJ cord-251986-ajlpb9li 14 23 system system NN cord-251986-ajlpb9li 14 24 inducing induce VBG cord-251986-ajlpb9li 14 25 neurological neurological JJ cord-251986-ajlpb9li 14 26 diseases disease NNS cord-251986-ajlpb9li 14 27 . . . cord-251986-ajlpb9li 15 1 The the DT cord-251986-ajlpb9li 15 2 infection infection NN cord-251986-ajlpb9li 15 3 of of IN cord-251986-ajlpb9li 15 4 SARS‐CoV SARS‐CoV NNP cord-251986-ajlpb9li 15 5 has have VBZ cord-251986-ajlpb9li 15 6 been be VBN cord-251986-ajlpb9li 15 7 reported report VBN cord-251986-ajlpb9li 15 8 in in IN cord-251986-ajlpb9li 15 9 the the DT cord-251986-ajlpb9li 15 10 brains brain NNS cord-251986-ajlpb9li 15 11 from from IN cord-251986-ajlpb9li 15 12 both both DT cord-251986-ajlpb9li 15 13 patients patient NNS cord-251986-ajlpb9li 15 14 and and CC cord-251986-ajlpb9li 15 15 experimental experimental JJ cord-251986-ajlpb9li 15 16 animals animal NNS cord-251986-ajlpb9li 15 17 , , , cord-251986-ajlpb9li 15 18 where where WRB cord-251986-ajlpb9li 15 19 the the DT cord-251986-ajlpb9li 15 20 brainstem brainstem NN cord-251986-ajlpb9li 15 21 was be VBD cord-251986-ajlpb9li 15 22 heavily heavily RB cord-251986-ajlpb9li 15 23 infected infect VBN cord-251986-ajlpb9li 15 24 . . . cord-251986-ajlpb9li 16 1 Furthermore furthermore RB cord-251986-ajlpb9li 16 2 , , , cord-251986-ajlpb9li 16 3 some some DT cord-251986-ajlpb9li 16 4 coronaviruses coronaviruse NNS cord-251986-ajlpb9li 16 5 have have VBP cord-251986-ajlpb9li 16 6 been be VBN cord-251986-ajlpb9li 16 7 demonstrated demonstrate VBN cord-251986-ajlpb9li 16 8 able able JJ cord-251986-ajlpb9li 16 9 to to TO cord-251986-ajlpb9li 16 10 spread spread VB cord-251986-ajlpb9li 16 11 via via IN cord-251986-ajlpb9li 16 12 a a DT cord-251986-ajlpb9li 16 13 synapse‐connected synapse‐connected JJ cord-251986-ajlpb9li 16 14 route route NN cord-251986-ajlpb9li 16 15 to to IN cord-251986-ajlpb9li 16 16 the the DT cord-251986-ajlpb9li 16 17 medullary medullary JJ cord-251986-ajlpb9li 16 18 cardiorespiratory cardiorespiratory JJ cord-251986-ajlpb9li 16 19 center center NN cord-251986-ajlpb9li 16 20 from from IN cord-251986-ajlpb9li 16 21 the the DT cord-251986-ajlpb9li 16 22 mechanoreceptors mechanoreceptor NNS cord-251986-ajlpb9li 16 23 and and CC cord-251986-ajlpb9li 16 24 chemoreceptors chemoreceptor NNS cord-251986-ajlpb9li 16 25 in in IN cord-251986-ajlpb9li 16 26 the the DT cord-251986-ajlpb9li 16 27 lung lung NN cord-251986-ajlpb9li 16 28 and and CC cord-251986-ajlpb9li 16 29 lower low JJR cord-251986-ajlpb9li 16 30 respiratory respiratory JJ cord-251986-ajlpb9li 16 31 airways airway NNS cord-251986-ajlpb9li 16 32 . . . cord-251986-ajlpb9li 17 1 Considering consider VBG cord-251986-ajlpb9li 17 2 the the DT cord-251986-ajlpb9li 17 3 high high JJ cord-251986-ajlpb9li 17 4 similarity similarity NN cord-251986-ajlpb9li 17 5 between between IN cord-251986-ajlpb9li 17 6 SARS‐CoV sars‐cov NN cord-251986-ajlpb9li 17 7 and and CC cord-251986-ajlpb9li 17 8 SARS‐CoV2 SARS‐CoV2 NNP cord-251986-ajlpb9li 17 9 , , , cord-251986-ajlpb9li 17 10 it -PRON- PRP cord-251986-ajlpb9li 17 11 remains remain VBZ cord-251986-ajlpb9li 17 12 to to TO cord-251986-ajlpb9li 17 13 make make VB cord-251986-ajlpb9li 17 14 clear clear JJ cord-251986-ajlpb9li 17 15 whether whether IN cord-251986-ajlpb9li 17 16 the the DT cord-251986-ajlpb9li 17 17 potential potential JJ cord-251986-ajlpb9li 17 18 invasion invasion NN cord-251986-ajlpb9li 17 19 of of IN cord-251986-ajlpb9li 17 20 SARS‐CoV2 SARS‐CoV2 NNP cord-251986-ajlpb9li 17 21 is be VBZ cord-251986-ajlpb9li 17 22 partially partially RB cord-251986-ajlpb9li 17 23 responsible responsible JJ cord-251986-ajlpb9li 17 24 for for IN cord-251986-ajlpb9li 17 25 the the DT cord-251986-ajlpb9li 17 26 acute acute JJ cord-251986-ajlpb9li 17 27 respiratory respiratory JJ cord-251986-ajlpb9li 17 28 failure failure NN cord-251986-ajlpb9li 17 29 of of IN cord-251986-ajlpb9li 17 30 patients patient NNS cord-251986-ajlpb9li 17 31 with with IN cord-251986-ajlpb9li 17 32 COVID‐19 COVID‐19 NNP cord-251986-ajlpb9li 17 33 . . . cord-251986-ajlpb9li 18 1 Awareness awareness NN cord-251986-ajlpb9li 18 2 of of IN cord-251986-ajlpb9li 18 3 this this DT cord-251986-ajlpb9li 18 4 may may MD cord-251986-ajlpb9li 18 5 have have VB cord-251986-ajlpb9li 18 6 a a DT cord-251986-ajlpb9li 18 7 guiding guide VBG cord-251986-ajlpb9li 18 8 significance significance NN cord-251986-ajlpb9li 18 9 for for IN cord-251986-ajlpb9li 18 10 the the DT cord-251986-ajlpb9li 18 11 prevention prevention NN cord-251986-ajlpb9li 18 12 and and CC cord-251986-ajlpb9li 18 13 treatment treatment NN cord-251986-ajlpb9li 18 14 of of IN cord-251986-ajlpb9li 18 15 the the DT cord-251986-ajlpb9li 18 16 SARS‐CoV‐2‐induced sars‐cov‐2‐induce VBN cord-251986-ajlpb9li 18 17 respiratory respiratory JJ cord-251986-ajlpb9li 18 18 failure failure NN cord-251986-ajlpb9li 18 19 . . . cord-251986-ajlpb9li 19 1 Increasing increase VBG cord-251986-ajlpb9li 19 2 evidence evidence NN cord-251986-ajlpb9li 19 3 shows show VBZ cord-251986-ajlpb9li 19 4 that that IN cord-251986-ajlpb9li 19 5 coronaviruses coronaviruse NNS cord-251986-ajlpb9li 19 6 are be VBP cord-251986-ajlpb9li 19 7 not not RB cord-251986-ajlpb9li 19 8 always always RB cord-251986-ajlpb9li 19 9 confined confine VBN cord-251986-ajlpb9li 19 10 to to IN cord-251986-ajlpb9li 19 11 the the DT cord-251986-ajlpb9li 19 12 respiratory respiratory JJ cord-251986-ajlpb9li 19 13 tract tract NN cord-251986-ajlpb9li 19 14 and and CC cord-251986-ajlpb9li 19 15 that that IN cord-251986-ajlpb9li 19 16 they -PRON- PRP cord-251986-ajlpb9li 19 17 may may MD cord-251986-ajlpb9li 19 18 also also RB cord-251986-ajlpb9li 19 19 invade invade VB cord-251986-ajlpb9li 19 20 the the DT cord-251986-ajlpb9li 19 21 central central JJ cord-251986-ajlpb9li 19 22 nervous nervous JJ cord-251986-ajlpb9li 19 23 system system NN cord-251986-ajlpb9li 19 24 inducing induce VBG cord-251986-ajlpb9li 19 25 neurological neurological JJ cord-251986-ajlpb9li 19 26 diseases disease NNS cord-251986-ajlpb9li 19 27 . . . cord-251986-ajlpb9li 20 1 The the DT cord-251986-ajlpb9li 20 2 infection infection NN cord-251986-ajlpb9li 20 3 of of IN cord-251986-ajlpb9li 20 4 SARS SARS NNP cord-251986-ajlpb9li 20 5 - - HYPH cord-251986-ajlpb9li 20 6 CoV CoV NNP cord-251986-ajlpb9li 20 7 has have VBZ cord-251986-ajlpb9li 20 8 been be VBN cord-251986-ajlpb9li 20 9 reported report VBN cord-251986-ajlpb9li 20 10 in in IN cord-251986-ajlpb9li 20 11 the the DT cord-251986-ajlpb9li 20 12 brains brain NNS cord-251986-ajlpb9li 20 13 from from IN cord-251986-ajlpb9li 20 14 both both DT cord-251986-ajlpb9li 20 15 patients patient NNS cord-251986-ajlpb9li 20 16 and and CC cord-251986-ajlpb9li 20 17 experimental experimental JJ cord-251986-ajlpb9li 20 18 animals animal NNS cord-251986-ajlpb9li 20 19 , , , cord-251986-ajlpb9li 20 20 where where WRB cord-251986-ajlpb9li 20 21 the the DT cord-251986-ajlpb9li 20 22 brainstem brainstem NN cord-251986-ajlpb9li 20 23 was be VBD cord-251986-ajlpb9li 20 24 heavily heavily RB cord-251986-ajlpb9li 20 25 infected infect VBN cord-251986-ajlpb9li 20 26 . . . cord-251986-ajlpb9li 21 1 Furthermore furthermore RB cord-251986-ajlpb9li 21 2 , , , cord-251986-ajlpb9li 21 3 some some DT cord-251986-ajlpb9li 21 4 coronaviruses coronaviruse NNS cord-251986-ajlpb9li 21 5 have have VBP cord-251986-ajlpb9li 21 6 been be VBN cord-251986-ajlpb9li 21 7 demonstrated demonstrate VBN cord-251986-ajlpb9li 21 8 able able JJ cord-251986-ajlpb9li 21 9 to to TO cord-251986-ajlpb9li 21 10 spread spread VB cord-251986-ajlpb9li 21 11 via via IN cord-251986-ajlpb9li 21 12 a a DT cord-251986-ajlpb9li 21 13 synapse synapse NN cord-251986-ajlpb9li 21 14 - - HYPH cord-251986-ajlpb9li 21 15 connected connect VBN cord-251986-ajlpb9li 21 16 route route NN cord-251986-ajlpb9li 21 17 to to IN cord-251986-ajlpb9li 21 18 the the DT cord-251986-ajlpb9li 21 19 medullary medullary JJ cord-251986-ajlpb9li 21 20 cardiorespiratory cardiorespiratory JJ cord-251986-ajlpb9li 21 21 center center NN cord-251986-ajlpb9li 21 22 from from IN cord-251986-ajlpb9li 21 23 the the DT cord-251986-ajlpb9li 21 24 mechanoreceptors mechanoreceptor NNS cord-251986-ajlpb9li 21 25 and and CC cord-251986-ajlpb9li 21 26 chemoreceptors chemoreceptor NNS cord-251986-ajlpb9li 21 27 in in IN cord-251986-ajlpb9li 21 28 the the DT cord-251986-ajlpb9li 21 29 lung lung NN cord-251986-ajlpb9li 21 30 and and CC cord-251986-ajlpb9li 21 31 lower low JJR cord-251986-ajlpb9li 21 32 respiratory respiratory JJ cord-251986-ajlpb9li 21 33 airways airway NNS cord-251986-ajlpb9li 21 34 . . . cord-251986-ajlpb9li 22 1 Considering consider VBG cord-251986-ajlpb9li 22 2 the the DT cord-251986-ajlpb9li 22 3 high high JJ cord-251986-ajlpb9li 22 4 similarity similarity NN cord-251986-ajlpb9li 22 5 between between IN cord-251986-ajlpb9li 22 6 SARS SARS NNP cord-251986-ajlpb9li 22 7 - - HYPH cord-251986-ajlpb9li 22 8 CoV CoV NNP cord-251986-ajlpb9li 22 9 and and CC cord-251986-ajlpb9li 22 10 SARS SARS NNP cord-251986-ajlpb9li 22 11 - - HYPH cord-251986-ajlpb9li 22 12 CoV2 CoV2 NNP cord-251986-ajlpb9li 22 13 , , , cord-251986-ajlpb9li 22 14 it -PRON- PRP cord-251986-ajlpb9li 22 15 remains remain VBZ cord-251986-ajlpb9li 22 16 to to TO cord-251986-ajlpb9li 22 17 make make VB cord-251986-ajlpb9li 22 18 clear clear JJ cord-251986-ajlpb9li 22 19 whether whether IN cord-251986-ajlpb9li 22 20 the the DT cord-251986-ajlpb9li 22 21 potential potential JJ cord-251986-ajlpb9li 22 22 invasion invasion NN cord-251986-ajlpb9li 22 23 of of IN cord-251986-ajlpb9li 22 24 SARS SARS NNP cord-251986-ajlpb9li 22 25 - - HYPH cord-251986-ajlpb9li 22 26 CoV2 CoV2 NNP cord-251986-ajlpb9li 22 27 is be VBZ cord-251986-ajlpb9li 22 28 partially partially RB cord-251986-ajlpb9li 22 29 responsible responsible JJ cord-251986-ajlpb9li 22 30 for for IN cord-251986-ajlpb9li 22 31 the the DT cord-251986-ajlpb9li 22 32 acute acute JJ cord-251986-ajlpb9li 22 33 respiratory respiratory JJ cord-251986-ajlpb9li 22 34 failure failure NN cord-251986-ajlpb9li 22 35 of of IN cord-251986-ajlpb9li 22 36 patients patient NNS cord-251986-ajlpb9li 22 37 with with IN cord-251986-ajlpb9li 22 38 COVID-19 COVID-19 NNP cord-251986-ajlpb9li 22 39 . . . cord-251986-ajlpb9li 23 1 Awareness awareness NN cord-251986-ajlpb9li 23 2 of of IN cord-251986-ajlpb9li 23 3 this this DT cord-251986-ajlpb9li 23 4 may may MD cord-251986-ajlpb9li 23 5 have have VB cord-251986-ajlpb9li 23 6 a a DT cord-251986-ajlpb9li 23 7 guiding guide VBG cord-251986-ajlpb9li 23 8 significance significance NN cord-251986-ajlpb9li 23 9 for for IN cord-251986-ajlpb9li 23 10 the the DT cord-251986-ajlpb9li 23 11 prevention prevention NN cord-251986-ajlpb9li 23 12 and and CC cord-251986-ajlpb9li 23 13 treatment treatment NN cord-251986-ajlpb9li 23 14 of of IN cord-251986-ajlpb9li 23 15 the the DT cord-251986-ajlpb9li 23 16 SARS SARS NNP cord-251986-ajlpb9li 23 17 - - HYPH cord-251986-ajlpb9li 23 18 CoV-2-induced cov-2-induce VBN cord-251986-ajlpb9li 23 19 respiratory respiratory JJ cord-251986-ajlpb9li 23 20 failure failure NN cord-251986-ajlpb9li 23 21 . . . cord-251986-ajlpb9li 24 1 Genomic genomic JJ cord-251986-ajlpb9li 24 2 analysis analysis NN cord-251986-ajlpb9li 24 3 shows show VBZ cord-251986-ajlpb9li 24 4 that that IN cord-251986-ajlpb9li 24 5 SARS SARS NNP cord-251986-ajlpb9li 24 6 - - HYPH cord-251986-ajlpb9li 24 7 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 24 8 is be VBZ cord-251986-ajlpb9li 24 9 in in IN cord-251986-ajlpb9li 24 10 the the DT cord-251986-ajlpb9li 24 11 same same JJ cord-251986-ajlpb9li 24 12 betacoronavirus betacoronavirus NN cord-251986-ajlpb9li 24 13 ( ( -LRB- cord-251986-ajlpb9li 24 14 βCoV βCoV NNP cord-251986-ajlpb9li 24 15 ) ) -RRB- cord-251986-ajlpb9li 24 16 clade clade NN cord-251986-ajlpb9li 24 17 as as IN cord-251986-ajlpb9li 24 18 MERS MERS NNP cord-251986-ajlpb9li 24 19 - - HYPH cord-251986-ajlpb9li 24 20 CoV CoV NNP cord-251986-ajlpb9li 24 21 and and CC cord-251986-ajlpb9li 24 22 SARS SARS NNP cord-251986-ajlpb9li 24 23 - - HYPH cord-251986-ajlpb9li 24 24 CoV CoV NNP cord-251986-ajlpb9li 24 25 , , , cord-251986-ajlpb9li 24 26 and and CC cord-251986-ajlpb9li 24 27 shares share NNS cord-251986-ajlpb9li 24 28 highly highly RB cord-251986-ajlpb9li 24 29 homological homological JJ cord-251986-ajlpb9li 24 30 sequence sequence NN cord-251986-ajlpb9li 24 31 with with IN cord-251986-ajlpb9li 24 32 SARS SARS NNP cord-251986-ajlpb9li 24 33 - - HYPH cord-251986-ajlpb9li 24 34 CoV. CoV. NNP cord-251986-ajlpb9li 24 35 3 3 CD cord-251986-ajlpb9li 25 1 The the DT cord-251986-ajlpb9li 25 2 public public JJ cord-251986-ajlpb9li 25 3 evidence evidence NN cord-251986-ajlpb9li 25 4 shows show VBZ cord-251986-ajlpb9li 25 5 that that IN cord-251986-ajlpb9li 25 6 COVID-19 covid-19 JJ cord-251986-ajlpb9li 25 7 shares share NNS cord-251986-ajlpb9li 25 8 similar similar JJ cord-251986-ajlpb9li 25 9 pathogenesis pathogenesis NN cord-251986-ajlpb9li 25 10 with with IN cord-251986-ajlpb9li 25 11 the the DT cord-251986-ajlpb9li 25 12 pneumonia pneumonia NN cord-251986-ajlpb9li 25 13 induced induce VBN cord-251986-ajlpb9li 25 14 by by IN cord-251986-ajlpb9li 25 15 SARS SARS NNP cord-251986-ajlpb9li 25 16 - - HYPH cord-251986-ajlpb9li 25 17 CoV CoV NNP cord-251986-ajlpb9li 25 18 or or CC cord-251986-ajlpb9li 25 19 MERS MERS NNP cord-251986-ajlpb9li 25 20 - - HYPH cord-251986-ajlpb9li 25 21 CoV. CoV. NNP cord-251986-ajlpb9li 25 22 4 4 CD cord-251986-ajlpb9li 26 1 Moreover moreover RB cord-251986-ajlpb9li 26 2 , , , cord-251986-ajlpb9li 26 3 the the DT cord-251986-ajlpb9li 26 4 entry entry NN cord-251986-ajlpb9li 26 5 of of IN cord-251986-ajlpb9li 26 6 SARS SARS NNP cord-251986-ajlpb9li 26 7 - - HYPH cord-251986-ajlpb9li 26 8 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 26 9 into into IN cord-251986-ajlpb9li 26 10 human human JJ cord-251986-ajlpb9li 26 11 host host NN cord-251986-ajlpb9li 26 12 cells cell NNS cord-251986-ajlpb9li 26 13 has have VBZ cord-251986-ajlpb9li 26 14 been be VBN cord-251986-ajlpb9li 26 15 identified identify VBN cord-251986-ajlpb9li 26 16 to to TO cord-251986-ajlpb9li 26 17 use use VB cord-251986-ajlpb9li 26 18 the the DT cord-251986-ajlpb9li 26 19 same same JJ cord-251986-ajlpb9li 26 20 receptor receptor NN cord-251986-ajlpb9li 26 21 as as IN cord-251986-ajlpb9li 26 22 SARS SARS NNP cord-251986-ajlpb9li 26 23 - - HYPH cord-251986-ajlpb9li 26 24 CoV. CoV. NNP cord-251986-ajlpb9li 26 25 5 5 CD cord-251986-ajlpb9li 26 26 , , , cord-251986-ajlpb9li 26 27 6 6 CD cord-251986-ajlpb9li 26 28 Most Most JJS cord-251986-ajlpb9li 26 29 CoVs CoVs NNP cord-251986-ajlpb9li 26 30 share share VBP cord-251986-ajlpb9li 26 31 a a DT cord-251986-ajlpb9li 26 32 similar similar JJ cord-251986-ajlpb9li 26 33 viral viral JJ cord-251986-ajlpb9li 26 34 structure structure NN cord-251986-ajlpb9li 26 35 and and CC cord-251986-ajlpb9li 26 36 infection infection NN cord-251986-ajlpb9li 26 37 pathway pathway NN cord-251986-ajlpb9li 26 38 , , , cord-251986-ajlpb9li 26 39 7 7 CD cord-251986-ajlpb9li 26 40 , , , cord-251986-ajlpb9li 26 41 8 8 CD cord-251986-ajlpb9li 26 42 and and CC cord-251986-ajlpb9li 26 43 therefore therefore RB cord-251986-ajlpb9li 26 44 the the DT cord-251986-ajlpb9li 26 45 infection infection NN cord-251986-ajlpb9li 26 46 mechanisms mechanism NNS cord-251986-ajlpb9li 26 47 previously previously RB cord-251986-ajlpb9li 26 48 found find VBN cord-251986-ajlpb9li 26 49 for for IN cord-251986-ajlpb9li 26 50 other other JJ cord-251986-ajlpb9li 26 51 CoVs CoVs NNP cord-251986-ajlpb9li 27 1 may may MD cord-251986-ajlpb9li 27 2 also also RB cord-251986-ajlpb9li 27 3 be be VB cord-251986-ajlpb9li 27 4 applicable applicable JJ cord-251986-ajlpb9li 27 5 for for IN cord-251986-ajlpb9li 27 6 SARS SARS NNP cord-251986-ajlpb9li 27 7 - - HYPH cord-251986-ajlpb9li 27 8 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 27 9 . . . cord-251986-ajlpb9li 28 1 A a DT cord-251986-ajlpb9li 28 2 growing grow VBG cord-251986-ajlpb9li 28 3 body body NN cord-251986-ajlpb9li 28 4 of of IN cord-251986-ajlpb9li 28 5 evidence evidence NN cord-251986-ajlpb9li 28 6 shows show VBZ cord-251986-ajlpb9li 28 7 that that IN cord-251986-ajlpb9li 28 8 neurotropism neurotropism NN cord-251986-ajlpb9li 28 9 is be VBZ cord-251986-ajlpb9li 28 10 one one CD cord-251986-ajlpb9li 28 11 common common JJ cord-251986-ajlpb9li 28 12 feature feature NN cord-251986-ajlpb9li 28 13 of of IN cord-251986-ajlpb9li 28 14 CoVs CoVs NNP cord-251986-ajlpb9li 28 15 . . . cord-251986-ajlpb9li 29 1 1 1 LS cord-251986-ajlpb9li 29 2 , , , cord-251986-ajlpb9li 29 3 [ [ -LRB- cord-251986-ajlpb9li 29 4 9 9 CD cord-251986-ajlpb9li 29 5 ] ] -RRB- cord-251986-ajlpb9li 29 6 [ [ -LRB- cord-251986-ajlpb9li 29 7 10 10 CD cord-251986-ajlpb9li 29 8 ] ] -RRB- cord-251986-ajlpb9li 29 9 [ [ -LRB- cord-251986-ajlpb9li 29 10 11 11 CD cord-251986-ajlpb9li 29 11 ] ] -RRB- cord-251986-ajlpb9li 30 1 [ [ -LRB- cord-251986-ajlpb9li 30 2 12 12 CD cord-251986-ajlpb9li 30 3 ] ] -RRB- cord-251986-ajlpb9li 31 1 Therefore therefore RB cord-251986-ajlpb9li 31 2 , , , cord-251986-ajlpb9li 31 3 it -PRON- PRP cord-251986-ajlpb9li 31 4 is be VBZ cord-251986-ajlpb9li 31 5 urgent urgent JJ cord-251986-ajlpb9li 31 6 to to TO cord-251986-ajlpb9li 31 7 make make VB cord-251986-ajlpb9li 31 8 clear clear JJ cord-251986-ajlpb9li 31 9 whether whether IN cord-251986-ajlpb9li 31 10 SARS SARS NNP cord-251986-ajlpb9li 31 11 - - HYPH cord-251986-ajlpb9li 31 12 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 31 13 can can MD cord-251986-ajlpb9li 31 14 gain gain VB cord-251986-ajlpb9li 31 15 access access NN cord-251986-ajlpb9li 31 16 to to IN cord-251986-ajlpb9li 31 17 the the DT cord-251986-ajlpb9li 31 18 central central JJ cord-251986-ajlpb9li 31 19 nervous nervous JJ cord-251986-ajlpb9li 31 20 system system NN cord-251986-ajlpb9li 31 21 ( ( -LRB- cord-251986-ajlpb9li 31 22 CNS CNS NNP cord-251986-ajlpb9li 31 23 ) ) -RRB- cord-251986-ajlpb9li 31 24 and and CC cord-251986-ajlpb9li 31 25 induce induce VB cord-251986-ajlpb9li 31 26 neuronal neuronal JJ cord-251986-ajlpb9li 31 27 injury injury NN cord-251986-ajlpb9li 31 28 leading lead VBG cord-251986-ajlpb9li 31 29 to to IN cord-251986-ajlpb9li 31 30 the the DT cord-251986-ajlpb9li 31 31 acute acute JJ cord-251986-ajlpb9li 31 32 respiratory respiratory JJ cord-251986-ajlpb9li 31 33 distress distress NN cord-251986-ajlpb9li 31 34 . . . cord-251986-ajlpb9li 32 1 SARS SARS NNP cord-251986-ajlpb9li 32 2 - - HYPH cord-251986-ajlpb9li 32 3 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 32 4 causes cause VBZ cord-251986-ajlpb9li 32 5 acute acute JJ cord-251986-ajlpb9li 32 6 , , , cord-251986-ajlpb9li 32 7 highly highly RB cord-251986-ajlpb9li 32 8 lethal lethal JJ cord-251986-ajlpb9li 32 9 pneumonia pneumonia NN cord-251986-ajlpb9li 32 10 with with IN cord-251986-ajlpb9li 32 11 clinical clinical JJ cord-251986-ajlpb9li 32 12 symptoms symptom NNS cord-251986-ajlpb9li 32 13 similar similar JJ cord-251986-ajlpb9li 32 14 to to IN cord-251986-ajlpb9li 32 15 those those DT cord-251986-ajlpb9li 32 16 reported report VBN cord-251986-ajlpb9li 32 17 for for IN cord-251986-ajlpb9li 32 18 SARS SARS NNP cord-251986-ajlpb9li 32 19 - - HYPH cord-251986-ajlpb9li 32 20 CoV CoV NNP cord-251986-ajlpb9li 32 21 and and CC cord-251986-ajlpb9li 32 22 MERS MERS NNP cord-251986-ajlpb9li 32 23 - - HYPH cord-251986-ajlpb9li 32 24 CoV. CoV. NNP cord-251986-ajlpb9li 32 25 2 2 CD cord-251986-ajlpb9li 32 26 , , , cord-251986-ajlpb9li 32 27 11 11 CD cord-251986-ajlpb9li 32 28 Imaging Imaging NNP cord-251986-ajlpb9li 32 29 examination examination NN cord-251986-ajlpb9li 32 30 revealed reveal VBD cord-251986-ajlpb9li 32 31 that that IN cord-251986-ajlpb9li 32 32 most most JJS cord-251986-ajlpb9li 32 33 patients patient NNS cord-251986-ajlpb9li 32 34 with with IN cord-251986-ajlpb9li 32 35 fever fever NN cord-251986-ajlpb9li 32 36 , , , cord-251986-ajlpb9li 32 37 dry dry JJ cord-251986-ajlpb9li 32 38 cough cough NN cord-251986-ajlpb9li 32 39 , , , cord-251986-ajlpb9li 32 40 and and CC cord-251986-ajlpb9li 32 41 dyspnea dyspnea NN cord-251986-ajlpb9li 32 42 showed show VBD cord-251986-ajlpb9li 32 43 bilateral bilateral JJ cord-251986-ajlpb9li 32 44 ground ground NN cord-251986-ajlpb9li 32 45 - - HYPH cord-251986-ajlpb9li 32 46 glass glass NN cord-251986-ajlpb9li 32 47 opacities opacity NNS cord-251986-ajlpb9li 32 48 on on IN cord-251986-ajlpb9li 32 49 chest chest NN cord-251986-ajlpb9li 32 50 computerized computerized JJ cord-251986-ajlpb9li 32 51 tomography tomography NN cord-251986-ajlpb9li 32 52 scans scan NNS cord-251986-ajlpb9li 32 53 . . . cord-251986-ajlpb9li 33 1 12 12 CD cord-251986-ajlpb9li 34 1 However however RB cord-251986-ajlpb9li 34 2 , , , cord-251986-ajlpb9li 34 3 different different JJ cord-251986-ajlpb9li 34 4 from from IN cord-251986-ajlpb9li 34 5 SARS SARS NNP cord-251986-ajlpb9li 34 6 - - HYPH cord-251986-ajlpb9li 34 7 CoV CoV NNP cord-251986-ajlpb9li 34 8 , , , cord-251986-ajlpb9li 34 9 SARS SARS NNP cord-251986-ajlpb9li 34 10 - - HYPH cord-251986-ajlpb9li 34 11 CoV-2-infected cov-2-infecte VBN cord-251986-ajlpb9li 34 12 patients patient NNS cord-251986-ajlpb9li 34 13 rarely rarely RB cord-251986-ajlpb9li 34 14 showed show VBD cord-251986-ajlpb9li 34 15 prominent prominent JJ cord-251986-ajlpb9li 34 16 upper upper JJ cord-251986-ajlpb9li 34 17 respiratory respiratory JJ cord-251986-ajlpb9li 34 18 tract tract NN cord-251986-ajlpb9li 34 19 signs sign NNS cord-251986-ajlpb9li 34 20 and and CC cord-251986-ajlpb9li 34 21 symptoms symptom NNS cord-251986-ajlpb9li 34 22 , , , cord-251986-ajlpb9li 34 23 indicating indicate VBG cord-251986-ajlpb9li 34 24 that that IN cord-251986-ajlpb9li 34 25 the the DT cord-251986-ajlpb9li 34 26 target target NN cord-251986-ajlpb9li 34 27 cells cell NNS cord-251986-ajlpb9li 34 28 of of IN cord-251986-ajlpb9li 34 29 SARS SARS NNP cord-251986-ajlpb9li 34 30 - - HYPH cord-251986-ajlpb9li 34 31 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 34 32 may may MD cord-251986-ajlpb9li 34 33 be be VB cord-251986-ajlpb9li 34 34 located locate VBN cord-251986-ajlpb9li 34 35 in in IN cord-251986-ajlpb9li 34 36 the the DT cord-251986-ajlpb9li 34 37 lower low JJR cord-251986-ajlpb9li 34 38 airway airway NN cord-251986-ajlpb9li 34 39 . . . cord-251986-ajlpb9li 35 1 2 2 LS cord-251986-ajlpb9li 36 1 Based base VBN cord-251986-ajlpb9li 36 2 upon upon IN cord-251986-ajlpb9li 36 3 the the DT cord-251986-ajlpb9li 36 4 first first JJ cord-251986-ajlpb9li 36 5 - - HYPH cord-251986-ajlpb9li 36 6 hand hand NN cord-251986-ajlpb9li 36 7 evidence evidence NN cord-251986-ajlpb9li 36 8 from from IN cord-251986-ajlpb9li 36 9 Wuhan Wuhan NNP cord-251986-ajlpb9li 36 10 local local JJ cord-251986-ajlpb9li 36 11 hospitals hospital NNS cord-251986-ajlpb9li 36 12 , , , cord-251986-ajlpb9li 37 1 2,10,12 2,10,12 NFP cord-251986-ajlpb9li 37 2 the the DT cord-251986-ajlpb9li 37 3 common common JJ cord-251986-ajlpb9li 37 4 symptoms symptom NNS cord-251986-ajlpb9li 37 5 of of IN cord-251986-ajlpb9li 37 6 COVID-19 COVID-19 NNP cord-251986-ajlpb9li 37 7 were be VBD cord-251986-ajlpb9li 37 8 fever fever NN cord-251986-ajlpb9li 37 9 ( ( -LRB- cord-251986-ajlpb9li 37 10 83%-99 83%-99 CD cord-251986-ajlpb9li 37 11 % % NN cord-251986-ajlpb9li 37 12 ) ) -RRB- cord-251986-ajlpb9li 37 13 and and CC cord-251986-ajlpb9li 37 14 dry dry JJ cord-251986-ajlpb9li 37 15 cough cough NN cord-251986-ajlpb9li 37 16 ( ( -LRB- cord-251986-ajlpb9li 37 17 59.4%-82 59.4%-82 CD cord-251986-ajlpb9li 37 18 % % NN cord-251986-ajlpb9li 37 19 ) ) -RRB- cord-251986-ajlpb9li 37 20 at at IN cord-251986-ajlpb9li 37 21 the the DT cord-251986-ajlpb9li 37 22 onset onset NN cord-251986-ajlpb9li 37 23 of of IN cord-251986-ajlpb9li 37 24 illness illness NN cord-251986-ajlpb9li 37 25 . . . cord-251986-ajlpb9li 38 1 However however RB cord-251986-ajlpb9li 38 2 , , , cord-251986-ajlpb9li 38 3 the the DT cord-251986-ajlpb9li 38 4 most most RBS cord-251986-ajlpb9li 38 5 characteristic characteristic JJ cord-251986-ajlpb9li 38 6 symptom symptom NN cord-251986-ajlpb9li 38 7 of of IN cord-251986-ajlpb9li 38 8 patients patient NNS cord-251986-ajlpb9li 38 9 is be VBZ cord-251986-ajlpb9li 38 10 respiratory respiratory JJ cord-251986-ajlpb9li 38 11 distress distress NN cord-251986-ajlpb9li 38 12 ( ( -LRB- cord-251986-ajlpb9li 38 13 ~55 ~55 CD cord-251986-ajlpb9li 38 14 % % NN cord-251986-ajlpb9li 38 15 ) ) -RRB- cord-251986-ajlpb9li 38 16 . . . cord-251986-ajlpb9li 39 1 Among among IN cord-251986-ajlpb9li 39 2 the the DT cord-251986-ajlpb9li 39 3 patients patient NNS cord-251986-ajlpb9li 39 4 with with IN cord-251986-ajlpb9li 39 5 dyspnea dyspnea NN cord-251986-ajlpb9li 39 6 , , , cord-251986-ajlpb9li 39 7 more more JJR cord-251986-ajlpb9li 39 8 than than IN cord-251986-ajlpb9li 39 9 half half DT cord-251986-ajlpb9li 39 10 needed need VBN cord-251986-ajlpb9li 39 11 intensive intensive JJ cord-251986-ajlpb9li 39 12 care care NN cord-251986-ajlpb9li 39 13 . . . cord-251986-ajlpb9li 40 1 About about RB cord-251986-ajlpb9li 40 2 46 46 CD cord-251986-ajlpb9li 40 3 % % NN cord-251986-ajlpb9li 40 4 to to IN cord-251986-ajlpb9li 40 5 65 65 CD cord-251986-ajlpb9li 40 6 % % NN cord-251986-ajlpb9li 40 7 of of IN cord-251986-ajlpb9li 40 8 the the DT cord-251986-ajlpb9li 40 9 patients patient NNS cord-251986-ajlpb9li 40 10 in in IN cord-251986-ajlpb9li 40 11 the the DT cord-251986-ajlpb9li 40 12 intensive intensive JJ cord-251986-ajlpb9li 40 13 care care NN cord-251986-ajlpb9li 40 14 worsened worsen VBD cord-251986-ajlpb9li 40 15 in in IN cord-251986-ajlpb9li 40 16 a a DT cord-251986-ajlpb9li 40 17 short short JJ cord-251986-ajlpb9li 40 18 period period NN cord-251986-ajlpb9li 40 19 of of IN cord-251986-ajlpb9li 40 20 time time NN cord-251986-ajlpb9li 40 21 and and CC cord-251986-ajlpb9li 40 22 died die VBD cord-251986-ajlpb9li 40 23 due due IN cord-251986-ajlpb9li 40 24 to to IN cord-251986-ajlpb9li 40 25 respiratory respiratory JJ cord-251986-ajlpb9li 40 26 failure failure NN cord-251986-ajlpb9li 40 27 . . . cord-251986-ajlpb9li 41 1 Among among IN cord-251986-ajlpb9li 41 2 the the DT cord-251986-ajlpb9li 41 3 36 36 CD cord-251986-ajlpb9li 41 4 cases case NNS cord-251986-ajlpb9li 41 5 in in IN cord-251986-ajlpb9li 41 6 the the DT cord-251986-ajlpb9li 41 7 intensive intensive JJ cord-251986-ajlpb9li 41 8 care care NN cord-251986-ajlpb9li 41 9 reported report VBN cord-251986-ajlpb9li 41 10 by by IN cord-251986-ajlpb9li 41 11 Wang Wang NNP cord-251986-ajlpb9li 41 12 et et NNP cord-251986-ajlpb9li 41 13 al al NNP cord-251986-ajlpb9li 41 14 , , , cord-251986-ajlpb9li 41 15 10 10 CD cord-251986-ajlpb9li 41 16 11.1 11.1 CD cord-251986-ajlpb9li 41 17 % % NN cord-251986-ajlpb9li 41 18 received receive VBD cord-251986-ajlpb9li 41 19 highflow highflow NNP cord-251986-ajlpb9li 41 20 oxygen oxygen NN cord-251986-ajlpb9li 41 21 therapy therapy NN cord-251986-ajlpb9li 41 22 , , , cord-251986-ajlpb9li 41 23 41.7 41.7 CD cord-251986-ajlpb9li 41 24 % % NN cord-251986-ajlpb9li 41 25 received receive VBD cord-251986-ajlpb9li 41 26 noninvasive noninvasive JJ cord-251986-ajlpb9li 41 27 ventilation ventilation NN cord-251986-ajlpb9li 41 28 , , , cord-251986-ajlpb9li 41 29 and and CC cord-251986-ajlpb9li 41 30 47.2 47.2 CD cord-251986-ajlpb9li 41 31 % % NN cord-251986-ajlpb9li 41 32 received receive VBD cord-251986-ajlpb9li 41 33 invasive invasive JJ cord-251986-ajlpb9li 41 34 ventilation ventilation NN cord-251986-ajlpb9li 41 35 . . . cord-251986-ajlpb9li 42 1 These these DT cord-251986-ajlpb9li 42 2 data datum NNS cord-251986-ajlpb9li 42 3 suggest suggest VBP cord-251986-ajlpb9li 42 4 that that IN cord-251986-ajlpb9li 42 5 most most RBS cord-251986-ajlpb9li 42 6 ( ( -LRB- cord-251986-ajlpb9li 42 7 about about RB cord-251986-ajlpb9li 42 8 89 89 CD cord-251986-ajlpb9li 42 9 % % NN cord-251986-ajlpb9li 42 10 ) ) -RRB- cord-251986-ajlpb9li 42 11 of of IN cord-251986-ajlpb9li 42 12 the the DT cord-251986-ajlpb9li 42 13 patients patient NNS cord-251986-ajlpb9li 42 14 in in IN cord-251986-ajlpb9li 42 15 need need NN cord-251986-ajlpb9li 42 16 of of IN cord-251986-ajlpb9li 42 17 intensive intensive JJ cord-251986-ajlpb9li 42 18 care care NN cord-251986-ajlpb9li 42 19 could could MD cord-251986-ajlpb9li 42 20 not not RB cord-251986-ajlpb9li 42 21 breathe breathe VB cord-251986-ajlpb9li 42 22 spontaneously spontaneously RB cord-251986-ajlpb9li 42 23 . . . cord-251986-ajlpb9li 43 1 It -PRON- PRP cord-251986-ajlpb9li 43 2 is be VBZ cord-251986-ajlpb9li 43 3 now now RB cord-251986-ajlpb9li 43 4 known know VBN cord-251986-ajlpb9li 43 5 that that IN cord-251986-ajlpb9li 43 6 CoVs CoVs NNP cord-251986-ajlpb9li 43 7 are be VBP cord-251986-ajlpb9li 43 8 not not RB cord-251986-ajlpb9li 43 9 always always RB cord-251986-ajlpb9li 43 10 confined confine VBN cord-251986-ajlpb9li 43 11 to to IN cord-251986-ajlpb9li 43 12 the the DT cord-251986-ajlpb9li 43 13 respiratory respiratory JJ cord-251986-ajlpb9li 43 14 tract tract NN cord-251986-ajlpb9li 43 15 and and CC cord-251986-ajlpb9li 43 16 that that IN cord-251986-ajlpb9li 43 17 they -PRON- PRP cord-251986-ajlpb9li 43 18 may may MD cord-251986-ajlpb9li 43 19 also also RB cord-251986-ajlpb9li 43 20 invade invade VB cord-251986-ajlpb9li 43 21 the the DT cord-251986-ajlpb9li 43 22 CNS CNS NNP cord-251986-ajlpb9li 43 23 inducing induce VBG cord-251986-ajlpb9li 43 24 neurological neurological JJ cord-251986-ajlpb9li 43 25 diseases disease NNS cord-251986-ajlpb9li 43 26 . . . cord-251986-ajlpb9li 44 1 Such such JJ cord-251986-ajlpb9li 44 2 neuroinvasive neuroinvasive JJ cord-251986-ajlpb9li 44 3 propensity propensity NN cord-251986-ajlpb9li 44 4 of of IN cord-251986-ajlpb9li 44 5 CoVs CoVs NNP cord-251986-ajlpb9li 44 6 has have VBZ cord-251986-ajlpb9li 44 7 been be VBN cord-251986-ajlpb9li 44 8 documented document VBN cord-251986-ajlpb9li 44 9 almost almost RB cord-251986-ajlpb9li 44 10 for for IN cord-251986-ajlpb9li 44 11 all all PDT cord-251986-ajlpb9li 44 12 the the DT cord-251986-ajlpb9li 44 13 βCoVs βCoVs NNP cord-251986-ajlpb9li 44 14 , , , cord-251986-ajlpb9li 44 15 including include VBG cord-251986-ajlpb9li 44 16 SARS SARS NNP cord-251986-ajlpb9li 44 17 - - HYPH cord-251986-ajlpb9li 44 18 CoV CoV NNP cord-251986-ajlpb9li 44 19 , , , cord-251986-ajlpb9li 44 20 1 1 CD cord-251986-ajlpb9li 44 21 MERS MERS NNP cord-251986-ajlpb9li 44 22 - - HYPH cord-251986-ajlpb9li 44 23 CoV CoV NNP cord-251986-ajlpb9li 44 24 , , , cord-251986-ajlpb9li 44 25 13 13 CD cord-251986-ajlpb9li 44 26 HCoV-229E HCoV-229E NNP cord-251986-ajlpb9li 44 27 , , , cord-251986-ajlpb9li 44 28 14 14 CD cord-251986-ajlpb9li 44 29 HCoV HCoV NNP cord-251986-ajlpb9li 44 30 - - HYPH cord-251986-ajlpb9li 44 31 OC43 OC43 NNP cord-251986-ajlpb9li 44 32 , , , cord-251986-ajlpb9li 44 33 15 15 CD cord-251986-ajlpb9li 44 34 mouse mouse NN cord-251986-ajlpb9li 44 35 hepatitis hepatitis NNP cord-251986-ajlpb9li 44 36 virus virus NN cord-251986-ajlpb9li 44 37 , , , cord-251986-ajlpb9li 44 38 16 16 CD cord-251986-ajlpb9li 44 39 and and CC cord-251986-ajlpb9li 44 40 porcine porcine JJ cord-251986-ajlpb9li 44 41 hemagglutinating hemagglutinate VBG cord-251986-ajlpb9li 44 42 encephalomyelitis encephalomyelitis NN cord-251986-ajlpb9li 44 43 coronavirus coronavirus NN cord-251986-ajlpb9li 44 44 ( ( -LRB- cord-251986-ajlpb9li 44 45 HEV HEV NNP cord-251986-ajlpb9li 44 46 ) ) -RRB- cord-251986-ajlpb9li 44 47 . . . cord-251986-ajlpb9li 45 1 9 9 CD cord-251986-ajlpb9li 45 2 , , , cord-251986-ajlpb9li 45 3 [ [ -LRB- cord-251986-ajlpb9li 45 4 17 17 CD cord-251986-ajlpb9li 45 5 ] ] -RRB- cord-251986-ajlpb9li 45 6 [ [ -LRB- cord-251986-ajlpb9li 45 7 18 18 CD cord-251986-ajlpb9li 45 8 ] ] -RRB- cord-251986-ajlpb9li 45 9 [ [ -LRB- cord-251986-ajlpb9li 45 10 19 19 CD cord-251986-ajlpb9li 45 11 ] ] -RRB- cord-251986-ajlpb9li 46 1 With with IN cord-251986-ajlpb9li 46 2 respect respect NN cord-251986-ajlpb9li 46 3 to to IN cord-251986-ajlpb9li 46 4 the the DT cord-251986-ajlpb9li 46 5 high high JJ cord-251986-ajlpb9li 46 6 similarity similarity NN cord-251986-ajlpb9li 46 7 between between IN cord-251986-ajlpb9li 46 8 SARS SARS NNP cord-251986-ajlpb9li 46 9 - - HYPH cord-251986-ajlpb9li 46 10 CoV CoV NNP cord-251986-ajlpb9li 46 11 and and CC cord-251986-ajlpb9li 46 12 SARS SARS NNP cord-251986-ajlpb9li 46 13 - - HYPH cord-251986-ajlpb9li 46 14 CoV2 CoV2 NNP cord-251986-ajlpb9li 46 15 , , , cord-251986-ajlpb9li 46 16 it -PRON- PRP cord-251986-ajlpb9li 46 17 remains remain VBZ cord-251986-ajlpb9li 46 18 to to TO cord-251986-ajlpb9li 46 19 know know VB cord-251986-ajlpb9li 46 20 whether whether IN cord-251986-ajlpb9li 46 21 the the DT cord-251986-ajlpb9li 46 22 potential potential JJ cord-251986-ajlpb9li 46 23 neuroinvasion neuroinvasion NN cord-251986-ajlpb9li 46 24 of of IN cord-251986-ajlpb9li 46 25 SARS SARS NNP cord-251986-ajlpb9li 46 26 - - HYPH cord-251986-ajlpb9li 46 27 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 46 28 plays play VBZ cord-251986-ajlpb9li 46 29 a a DT cord-251986-ajlpb9li 46 30 role role NN cord-251986-ajlpb9li 46 31 in in IN cord-251986-ajlpb9li 46 32 the the DT cord-251986-ajlpb9li 46 33 acute acute JJ cord-251986-ajlpb9li 46 34 respiratory respiratory JJ cord-251986-ajlpb9li 46 35 failure failure NN cord-251986-ajlpb9li 46 36 of of IN cord-251986-ajlpb9li 46 37 patients patient NNS cord-251986-ajlpb9li 46 38 with with IN cord-251986-ajlpb9li 46 39 COVID-19 COVID-19 NNP cord-251986-ajlpb9li 46 40 . . . cord-251986-ajlpb9li 47 1 It -PRON- PRP cord-251986-ajlpb9li 47 2 is be VBZ cord-251986-ajlpb9li 47 3 believed believe VBN cord-251986-ajlpb9li 47 4 that that IN cord-251986-ajlpb9li 47 5 the the DT cord-251986-ajlpb9li 47 6 tissue tissue NN cord-251986-ajlpb9li 47 7 distributions distribution NNS cord-251986-ajlpb9li 47 8 of of IN cord-251986-ajlpb9li 47 9 host host NN cord-251986-ajlpb9li 47 10 receptors receptor NNS cord-251986-ajlpb9li 47 11 are be VBP cord-251986-ajlpb9li 47 12 generally generally RB cord-251986-ajlpb9li 47 13 consistent consistent JJ cord-251986-ajlpb9li 47 14 with with IN cord-251986-ajlpb9li 47 15 the the DT cord-251986-ajlpb9li 47 16 tropisms tropism NNS cord-251986-ajlpb9li 47 17 of of IN cord-251986-ajlpb9li 47 18 viruses virus NNS cord-251986-ajlpb9li 47 19 . . . cord-251986-ajlpb9li 48 1 [ [ -LRB- cord-251986-ajlpb9li 48 2 20 20 CD cord-251986-ajlpb9li 48 3 ] ] -RRB- cord-251986-ajlpb9li 48 4 [ [ -LRB- cord-251986-ajlpb9li 48 5 21 21 CD cord-251986-ajlpb9li 48 6 ] ] -RRB- cord-251986-ajlpb9li 49 1 [ [ -LRB- cord-251986-ajlpb9li 49 2 22 22 CD cord-251986-ajlpb9li 49 3 ] ] -RRB- cord-251986-ajlpb9li 50 1 The the DT cord-251986-ajlpb9li 50 2 entry entry NN cord-251986-ajlpb9li 50 3 of of IN cord-251986-ajlpb9li 50 4 SARS SARS NNP cord-251986-ajlpb9li 50 5 - - HYPH cord-251986-ajlpb9li 50 6 CoV CoV NNP cord-251986-ajlpb9li 50 7 into into IN cord-251986-ajlpb9li 50 8 human human JJ cord-251986-ajlpb9li 50 9 host host NN cord-251986-ajlpb9li 50 10 cells cell NNS cord-251986-ajlpb9li 50 11 is be VBZ cord-251986-ajlpb9li 50 12 mediated mediate VBN cord-251986-ajlpb9li 50 13 mainly mainly RB cord-251986-ajlpb9li 50 14 by by IN cord-251986-ajlpb9li 50 15 a a DT cord-251986-ajlpb9li 50 16 cellular cellular JJ cord-251986-ajlpb9li 50 17 receptor receptor NN cord-251986-ajlpb9li 50 18 angiotensin angiotensin NN cord-251986-ajlpb9li 50 19 - - HYPH cord-251986-ajlpb9li 50 20 converting convert VBG cord-251986-ajlpb9li 50 21 enzyme enzyme NN cord-251986-ajlpb9li 50 22 2 2 CD cord-251986-ajlpb9li 50 23 ( ( -LRB- cord-251986-ajlpb9li 50 24 ACE2 ACE2 NNP cord-251986-ajlpb9li 50 25 ) ) -RRB- cord-251986-ajlpb9li 50 26 , , , cord-251986-ajlpb9li 50 27 which which WDT cord-251986-ajlpb9li 50 28 is be VBZ cord-251986-ajlpb9li 50 29 expressed express VBN cord-251986-ajlpb9li 50 30 in in IN cord-251986-ajlpb9li 50 31 human human JJ cord-251986-ajlpb9li 50 32 airway airway NN cord-251986-ajlpb9li 50 33 epithelia epithelium NNS cord-251986-ajlpb9li 50 34 , , , cord-251986-ajlpb9li 50 35 lung lung NN cord-251986-ajlpb9li 50 36 parenchyma parenchyma NN cord-251986-ajlpb9li 50 37 , , , cord-251986-ajlpb9li 50 38 vascular vascular JJ cord-251986-ajlpb9li 50 39 endothelia endothelia NNP cord-251986-ajlpb9li 50 40 , , , cord-251986-ajlpb9li 50 41 kidney kidney NN cord-251986-ajlpb9li 50 42 cells cell NNS cord-251986-ajlpb9li 50 43 , , , cord-251986-ajlpb9li 50 44 and and CC cord-251986-ajlpb9li 50 45 small small JJ cord-251986-ajlpb9li 50 46 intestine intestine NN cord-251986-ajlpb9li 50 47 cells cell NNS cord-251986-ajlpb9li 50 48 . . . cord-251986-ajlpb9li 51 1 [ [ -LRB- cord-251986-ajlpb9li 51 2 23 23 CD cord-251986-ajlpb9li 51 3 ] ] -RRB- cord-251986-ajlpb9li 51 4 [ [ -LRB- cord-251986-ajlpb9li 51 5 24 24 CD cord-251986-ajlpb9li 51 6 ] ] -RRB- cord-251986-ajlpb9li 51 7 [ [ -LRB- cord-251986-ajlpb9li 51 8 25 25 CD cord-251986-ajlpb9li 51 9 ] ] -RRB- cord-251986-ajlpb9li 52 1 Different different JJ cord-251986-ajlpb9li 52 2 from from IN cord-251986-ajlpb9li 52 3 SARS SARS NNP cord-251986-ajlpb9li 52 4 - - HYPH cord-251986-ajlpb9li 52 5 CoV CoV NNP cord-251986-ajlpb9li 52 6 , , , cord-251986-ajlpb9li 52 7 MERS MERS NNP cord-251986-ajlpb9li 52 8 - - HYPH cord-251986-ajlpb9li 52 9 CoV CoV NNP cord-251986-ajlpb9li 52 10 enters enter VBZ cord-251986-ajlpb9li 52 11 human human JJ cord-251986-ajlpb9li 52 12 host host NN cord-251986-ajlpb9li 52 13 cells cell NNS cord-251986-ajlpb9li 52 14 mainly mainly RB cord-251986-ajlpb9li 52 15 via via IN cord-251986-ajlpb9li 52 16 dipeptidyl dipeptidyl JJ cord-251986-ajlpb9li 52 17 peptidase peptidase NN cord-251986-ajlpb9li 52 18 4 4 CD cord-251986-ajlpb9li 52 19 ( ( -LRB- cord-251986-ajlpb9li 52 20 DPP4 DPP4 NNP cord-251986-ajlpb9li 52 21 ) ) -RRB- cord-251986-ajlpb9li 52 22 , , , cord-251986-ajlpb9li 52 23 which which WDT cord-251986-ajlpb9li 52 24 is be VBZ cord-251986-ajlpb9li 52 25 present present JJ cord-251986-ajlpb9li 52 26 in in IN cord-251986-ajlpb9li 52 27 the the DT cord-251986-ajlpb9li 52 28 lower low JJR cord-251986-ajlpb9li 52 29 respiratory respiratory JJ cord-251986-ajlpb9li 52 30 tract tract NN cord-251986-ajlpb9li 52 31 , , , cord-251986-ajlpb9li 52 32 kidney kidney NN cord-251986-ajlpb9li 52 33 , , , cord-251986-ajlpb9li 52 34 small small JJ cord-251986-ajlpb9li 52 35 intestine intestine NN cord-251986-ajlpb9li 52 36 , , , cord-251986-ajlpb9li 52 37 liver liver NN cord-251986-ajlpb9li 52 38 , , , cord-251986-ajlpb9li 52 39 and and CC cord-251986-ajlpb9li 52 40 the the DT cord-251986-ajlpb9li 52 41 cells cell NNS cord-251986-ajlpb9li 52 42 of of IN cord-251986-ajlpb9li 52 43 the the DT cord-251986-ajlpb9li 52 44 immune immune JJ cord-251986-ajlpb9li 52 45 system system NN cord-251986-ajlpb9li 52 46 . . . cord-251986-ajlpb9li 53 1 26 26 CD cord-251986-ajlpb9li 53 2 , , , cord-251986-ajlpb9li 53 3 27 27 CD cord-251986-ajlpb9li 54 1 However however RB cord-251986-ajlpb9li 54 2 , , , cord-251986-ajlpb9li 54 3 the the DT cord-251986-ajlpb9li 54 4 presence presence NN cord-251986-ajlpb9li 54 5 of of IN cord-251986-ajlpb9li 54 6 ACE2 ACE2 NNP cord-251986-ajlpb9li 54 7 or or CC cord-251986-ajlpb9li 54 8 DPP4 DPP4 NNP cord-251986-ajlpb9li 54 9 solely solely RB cord-251986-ajlpb9li 54 10 is be VBZ cord-251986-ajlpb9li 54 11 not not RB cord-251986-ajlpb9li 54 12 sufficient sufficient JJ cord-251986-ajlpb9li 54 13 in in IN cord-251986-ajlpb9li 54 14 the the DT cord-251986-ajlpb9li 54 15 brain brain NN cord-251986-ajlpb9li 54 16 , , , cord-251986-ajlpb9li 54 17 where where WRB cord-251986-ajlpb9li 54 18 they -PRON- PRP cord-251986-ajlpb9li 54 19 were be VBD cord-251986-ajlpb9li 54 20 located locate VBN cord-251986-ajlpb9li 54 21 almost almost RB cord-251986-ajlpb9li 54 22 exclusively exclusively RB cord-251986-ajlpb9li 54 23 in in IN cord-251986-ajlpb9li 54 24 the the DT cord-251986-ajlpb9li 54 25 neurons neuron NNS cord-251986-ajlpb9li 54 26 . . . cord-251986-ajlpb9li 55 1 [ [ -LRB- cord-251986-ajlpb9li 55 2 31 31 CD cord-251986-ajlpb9li 55 3 ] ] -RRB- cord-251986-ajlpb9li 55 4 [ [ -LRB- cord-251986-ajlpb9li 55 5 32 32 CD cord-251986-ajlpb9li 55 6 ] ] -RRB- cord-251986-ajlpb9li 55 7 [ [ -LRB- cord-251986-ajlpb9li 55 8 33 33 CD cord-251986-ajlpb9li 55 9 ] ] -RRB- cord-251986-ajlpb9li 55 10 Experimental experimental JJ cord-251986-ajlpb9li 55 11 studies study NNS cord-251986-ajlpb9li 55 12 using use VBG cord-251986-ajlpb9li 55 13 transgenic transgenic JJ cord-251986-ajlpb9li 55 14 mice mouse NNS cord-251986-ajlpb9li 55 15 further further RB cord-251986-ajlpb9li 55 16 revealed reveal VBD cord-251986-ajlpb9li 55 17 that that IN cord-251986-ajlpb9li 55 18 either either DT cord-251986-ajlpb9li 55 19 SARS SARS NNP cord-251986-ajlpb9li 55 20 - - HYPH cord-251986-ajlpb9li 55 21 CoV CoV NNP cord-251986-ajlpb9li 55 22 34 34 CD cord-251986-ajlpb9li 55 23 or or CC cord-251986-ajlpb9li 55 24 MERS MERS NNP cord-251986-ajlpb9li 55 25 - - HYPH cord-251986-ajlpb9li 55 26 COV COV NNP cord-251986-ajlpb9li 55 27 , , , cord-251986-ajlpb9li 55 28 13 13 CD cord-251986-ajlpb9li 55 29 when when WRB cord-251986-ajlpb9li 55 30 given give VBN cord-251986-ajlpb9li 55 31 intranasally intranasally RB cord-251986-ajlpb9li 55 32 , , , cord-251986-ajlpb9li 55 33 could could MD cord-251986-ajlpb9li 55 34 enter enter VB cord-251986-ajlpb9li 55 35 the the DT cord-251986-ajlpb9li 55 36 brain brain NN cord-251986-ajlpb9li 55 37 , , , cord-251986-ajlpb9li 55 38 possibly possibly RB cord-251986-ajlpb9li 55 39 via via IN cord-251986-ajlpb9li 55 40 the the DT cord-251986-ajlpb9li 55 41 olfactory olfactory JJ cord-251986-ajlpb9li 55 42 nerves nerve NNS cord-251986-ajlpb9li 55 43 , , , cord-251986-ajlpb9li 55 44 and and CC cord-251986-ajlpb9li 55 45 thereafter thereafter RB cord-251986-ajlpb9li 55 46 rapidly rapidly RB cord-251986-ajlpb9li 55 47 spread spread VBD cord-251986-ajlpb9li 55 48 to to IN cord-251986-ajlpb9li 55 49 some some DT cord-251986-ajlpb9li 55 50 specific specific JJ cord-251986-ajlpb9li 55 51 brain brain NN cord-251986-ajlpb9li 55 52 areas area NNS cord-251986-ajlpb9li 55 53 including include VBG cord-251986-ajlpb9li 55 54 thalamus thalamus NN cord-251986-ajlpb9li 55 55 and and CC cord-251986-ajlpb9li 55 56 brainstem brainstem NN cord-251986-ajlpb9li 55 57 . . . cord-251986-ajlpb9li 56 1 It -PRON- PRP cord-251986-ajlpb9li 56 2 is be VBZ cord-251986-ajlpb9li 56 3 noteworthy noteworthy JJ cord-251986-ajlpb9li 56 4 that that IN cord-251986-ajlpb9li 56 5 in in IN cord-251986-ajlpb9li 56 6 the the DT cord-251986-ajlpb9li 56 7 mice mouse NNS cord-251986-ajlpb9li 56 8 infected infect VBN cord-251986-ajlpb9li 56 9 with with IN cord-251986-ajlpb9li 56 10 low low JJ cord-251986-ajlpb9li 56 11 inoculum inoculum NN cord-251986-ajlpb9li 56 12 doses dose NNS cord-251986-ajlpb9li 56 13 of of IN cord-251986-ajlpb9li 56 14 MERS MERS NNP cord-251986-ajlpb9li 56 15 - - HYPH cord-251986-ajlpb9li 56 16 CoV CoV NNP cord-251986-ajlpb9li 56 17 virus virus NN cord-251986-ajlpb9li 56 18 particles particle NNS cord-251986-ajlpb9li 56 19 were be VBD cord-251986-ajlpb9li 56 20 detected detect VBN cord-251986-ajlpb9li 56 21 only only RB cord-251986-ajlpb9li 56 22 in in IN cord-251986-ajlpb9li 56 23 the the DT cord-251986-ajlpb9li 56 24 brain brain NN cord-251986-ajlpb9li 56 25 , , , cord-251986-ajlpb9li 56 26 but but CC cord-251986-ajlpb9li 56 27 not not RB cord-251986-ajlpb9li 56 28 in in IN cord-251986-ajlpb9li 56 29 the the DT cord-251986-ajlpb9li 56 30 lung lung NN cord-251986-ajlpb9li 56 31 , , , cord-251986-ajlpb9li 56 32 which which WDT cord-251986-ajlpb9li 56 33 indicates indicate VBZ cord-251986-ajlpb9li 56 34 that that IN cord-251986-ajlpb9li 56 35 the the DT cord-251986-ajlpb9li 56 36 infection infection NN cord-251986-ajlpb9li 56 37 in in IN cord-251986-ajlpb9li 56 38 the the DT cord-251986-ajlpb9li 56 39 CNS CNS NNP cord-251986-ajlpb9li 56 40 was be VBD cord-251986-ajlpb9li 56 41 more more RBR cord-251986-ajlpb9li 56 42 important important JJ cord-251986-ajlpb9li 56 43 for for IN cord-251986-ajlpb9li 56 44 the the DT cord-251986-ajlpb9li 56 45 high high JJ cord-251986-ajlpb9li 56 46 mortality mortality NN cord-251986-ajlpb9li 56 47 observed observe VBN cord-251986-ajlpb9li 56 48 in in IN cord-251986-ajlpb9li 56 49 the the DT cord-251986-ajlpb9li 56 50 infected infected JJ cord-251986-ajlpb9li 56 51 mice mouse NNS cord-251986-ajlpb9li 56 52 . . . cord-251986-ajlpb9li 57 1 13 13 CD cord-251986-ajlpb9li 58 1 Among among IN cord-251986-ajlpb9li 58 2 the the DT cord-251986-ajlpb9li 58 3 involved involved JJ cord-251986-ajlpb9li 58 4 brain brain NN cord-251986-ajlpb9li 58 5 areas area NNS cord-251986-ajlpb9li 58 6 , , , cord-251986-ajlpb9li 58 7 the the DT cord-251986-ajlpb9li 58 8 brainstem brainstem NN cord-251986-ajlpb9li 58 9 has have VBZ cord-251986-ajlpb9li 58 10 been be VBN cord-251986-ajlpb9li 58 11 demonstrated demonstrate VBN cord-251986-ajlpb9li 58 12 to to TO cord-251986-ajlpb9li 58 13 be be VB cord-251986-ajlpb9li 58 14 heavily heavily RB cord-251986-ajlpb9li 58 15 infected infect VBN cord-251986-ajlpb9li 58 16 by by IN cord-251986-ajlpb9li 58 17 SARS SARS NNP cord-251986-ajlpb9li 58 18 - - HYPH cord-251986-ajlpb9li 58 19 CoV CoV NNP cord-251986-ajlpb9li 58 20 34 34 CD cord-251986-ajlpb9li 58 21 , , , cord-251986-ajlpb9li 58 22 35 35 CD cord-251986-ajlpb9li 58 23 or or CC cord-251986-ajlpb9li 58 24 MERS MERS NNP cord-251986-ajlpb9li 58 25 - - HYPH cord-251986-ajlpb9li 58 26 CoV. CoV. NNP cord-251986-ajlpb9li 58 27 13 13 CD cord-251986-ajlpb9li 59 1 The the DT cord-251986-ajlpb9li 59 2 exact exact JJ cord-251986-ajlpb9li 59 3 route route NN cord-251986-ajlpb9li 59 4 by by IN cord-251986-ajlpb9li 59 5 which which WDT cord-251986-ajlpb9li 59 6 SARS SARS NNP cord-251986-ajlpb9li 59 7 - - HYPH cord-251986-ajlpb9li 59 8 CoV CoV NNP cord-251986-ajlpb9li 59 9 or or CC cord-251986-ajlpb9li 59 10 MERS MERS NNP cord-251986-ajlpb9li 59 11 - - HYPH cord-251986-ajlpb9li 59 12 COV COV NNP cord-251986-ajlpb9li 59 13 enters enter VBZ cord-251986-ajlpb9li 59 14 the the DT cord-251986-ajlpb9li 59 15 CNS CNS NNP cord-251986-ajlpb9li 59 16 is be VBZ cord-251986-ajlpb9li 59 17 still still RB cord-251986-ajlpb9li 59 18 not not RB cord-251986-ajlpb9li 59 19 reported report VBN cord-251986-ajlpb9li 59 20 . . . cord-251986-ajlpb9li 60 1 However however RB cord-251986-ajlpb9li 60 2 , , , cord-251986-ajlpb9li 60 3 hematogenous hematogenous JJ cord-251986-ajlpb9li 60 4 or or CC cord-251986-ajlpb9li 60 5 lymphatic lymphatic JJ cord-251986-ajlpb9li 60 6 route route NN cord-251986-ajlpb9li 60 7 seems seem VBZ cord-251986-ajlpb9li 60 8 impossible impossible JJ cord-251986-ajlpb9li 60 9 , , , cord-251986-ajlpb9li 60 10 especially especially RB cord-251986-ajlpb9li 60 11 in in IN cord-251986-ajlpb9li 60 12 the the DT cord-251986-ajlpb9li 60 13 early early JJ cord-251986-ajlpb9li 60 14 stage stage NN cord-251986-ajlpb9li 60 15 of of IN cord-251986-ajlpb9li 60 16 infection infection NN cord-251986-ajlpb9li 60 17 , , , cord-251986-ajlpb9li 60 18 since since IN cord-251986-ajlpb9li 60 19 almost almost RB cord-251986-ajlpb9li 60 20 no no DT cord-251986-ajlpb9li 60 21 virus virus NN cord-251986-ajlpb9li 60 22 particle particle NN cord-251986-ajlpb9li 60 23 was be VBD cord-251986-ajlpb9li 60 24 detected detect VBN cord-251986-ajlpb9li 60 25 in in IN cord-251986-ajlpb9li 60 26 the the DT cord-251986-ajlpb9li 60 27 nonneuronal nonneuronal JJ cord-251986-ajlpb9li 60 28 cells cell NNS cord-251986-ajlpb9li 60 29 in in IN cord-251986-ajlpb9li 60 30 the the DT cord-251986-ajlpb9li 60 31 infected infected JJ cord-251986-ajlpb9li 60 32 brain brain NN cord-251986-ajlpb9li 60 33 areas area NNS cord-251986-ajlpb9li 60 34 . . . cord-251986-ajlpb9li 61 1 [ [ -LRB- cord-251986-ajlpb9li 61 2 31 31 CD cord-251986-ajlpb9li 61 3 ] ] -RRB- cord-251986-ajlpb9li 61 4 [ [ -LRB- cord-251986-ajlpb9li 61 5 32 32 CD cord-251986-ajlpb9li 61 6 ] ] -RRB- cord-251986-ajlpb9li 61 7 [ [ -LRB- cord-251986-ajlpb9li 61 8 33 33 CD cord-251986-ajlpb9li 61 9 ] ] -RRB- cord-251986-ajlpb9li 62 1 On on IN cord-251986-ajlpb9li 62 2 the the DT cord-251986-ajlpb9li 62 3 other other JJ cord-251986-ajlpb9li 62 4 hand hand NN cord-251986-ajlpb9li 62 5 , , , cord-251986-ajlpb9li 62 6 increasing increase VBG cord-251986-ajlpb9li 62 7 evidence evidence NN cord-251986-ajlpb9li 62 8 shows show VBZ cord-251986-ajlpb9li 62 9 that that IN cord-251986-ajlpb9li 62 10 CoVs CoVs NNP cord-251986-ajlpb9li 62 11 may may MD cord-251986-ajlpb9li 62 12 first first RB cord-251986-ajlpb9li 62 13 invade invade VB cord-251986-ajlpb9li 62 14 peripheral peripheral JJ cord-251986-ajlpb9li 62 15 nerve nerve NN cord-251986-ajlpb9li 62 16 terminals terminal NNS cord-251986-ajlpb9li 62 17 , , , cord-251986-ajlpb9li 62 18 and and CC cord-251986-ajlpb9li 62 19 then then RB cord-251986-ajlpb9li 62 20 gain gain VB cord-251986-ajlpb9li 62 21 access access NN cord-251986-ajlpb9li 62 22 to to IN cord-251986-ajlpb9li 62 23 the the DT cord-251986-ajlpb9li 62 24 CNS CNS NNP cord-251986-ajlpb9li 62 25 via via IN cord-251986-ajlpb9li 62 26 a a DT cord-251986-ajlpb9li 62 27 synapse synapse NN cord-251986-ajlpb9li 62 28 - - HYPH cord-251986-ajlpb9li 62 29 connected connect VBN cord-251986-ajlpb9li 62 30 route route NN cord-251986-ajlpb9li 62 31 . . . cord-251986-ajlpb9li 63 1 9 9 CD cord-251986-ajlpb9li 63 2 , , , cord-251986-ajlpb9li 63 3 17 17 CD cord-251986-ajlpb9li 63 4 , , , cord-251986-ajlpb9li 63 5 19 19 CD cord-251986-ajlpb9li 63 6 , , , cord-251986-ajlpb9li 63 7 36 36 CD cord-251986-ajlpb9li 63 8 The the DT cord-251986-ajlpb9li 63 9 trans trans JJ cord-251986-ajlpb9li 63 10 - - JJ cord-251986-ajlpb9li 63 11 synaptic synaptic JJ cord-251986-ajlpb9li 63 12 transfer transfer NN cord-251986-ajlpb9li 63 13 has have VBZ cord-251986-ajlpb9li 63 14 been be VBN cord-251986-ajlpb9li 63 15 well well RB cord-251986-ajlpb9li 63 16 documented document VBN cord-251986-ajlpb9li 63 17 for for IN cord-251986-ajlpb9li 63 18 other other JJ cord-251986-ajlpb9li 63 19 CoVs CoVs NNP cord-251986-ajlpb9li 63 20 , , , cord-251986-ajlpb9li 63 21 such such JJ cord-251986-ajlpb9li 63 22 as as IN cord-251986-ajlpb9li 63 23 HEV67 HEV67 NNP cord-251986-ajlpb9li 63 24 9 9 CD cord-251986-ajlpb9li 63 25 - - HYPH cord-251986-ajlpb9li 63 26 10,18 10,18 CD cord-251986-ajlpb9li 63 27 - - SYM cord-251986-ajlpb9li 63 28 19 19 CD cord-251986-ajlpb9li 63 29 and and CC cord-251986-ajlpb9li 63 30 avian avian JJ cord-251986-ajlpb9li 63 31 bronchitis bronchitis NN cord-251986-ajlpb9li 63 32 virus virus NN cord-251986-ajlpb9li 63 33 . . . cord-251986-ajlpb9li 64 1 36 36 CD cord-251986-ajlpb9li 64 2 , , , cord-251986-ajlpb9li 64 3 37 37 CD cord-251986-ajlpb9li 64 4 HEV HEV NNP cord-251986-ajlpb9li 64 5 67N 67N NNS cord-251986-ajlpb9li 64 6 is be VBZ cord-251986-ajlpb9li 64 7 the the DT cord-251986-ajlpb9li 64 8 first first JJ cord-251986-ajlpb9li 64 9 CoV cov NN cord-251986-ajlpb9li 64 10 found find VBN cord-251986-ajlpb9li 64 11 to to TO cord-251986-ajlpb9li 64 12 invade invade VB cord-251986-ajlpb9li 64 13 the the DT cord-251986-ajlpb9li 64 14 porcine porcine JJ cord-251986-ajlpb9li 64 15 brain brain NN cord-251986-ajlpb9li 64 16 , , , cord-251986-ajlpb9li 64 17 and and CC cord-251986-ajlpb9li 64 18 it -PRON- PRP cord-251986-ajlpb9li 64 19 shares share VBZ cord-251986-ajlpb9li 64 20 more more JJR cord-251986-ajlpb9li 64 21 than than IN cord-251986-ajlpb9li 64 22 91 91 CD cord-251986-ajlpb9li 64 23 % % NN cord-251986-ajlpb9li 64 24 homology homology NN cord-251986-ajlpb9li 64 25 with with IN cord-251986-ajlpb9li 64 26 HCoV HCoV NNP cord-251986-ajlpb9li 64 27 - - HYPH cord-251986-ajlpb9li 64 28 OC43 OC43 NNP cord-251986-ajlpb9li 64 29 . . . cord-251986-ajlpb9li 65 1 38 38 CD cord-251986-ajlpb9li 65 2 , , , cord-251986-ajlpb9li 65 3 39 39 CD cord-251986-ajlpb9li 65 4 HEV hev NN cord-251986-ajlpb9li 65 5 first first RB cord-251986-ajlpb9li 65 6 oronasally oronasally RB cord-251986-ajlpb9li 65 7 infects infect VBZ cord-251986-ajlpb9li 65 8 the the DT cord-251986-ajlpb9li 65 9 nasal nasal NN cord-251986-ajlpb9li 65 10 mucosa mucosa JJ cord-251986-ajlpb9li 65 11 , , , cord-251986-ajlpb9li 65 12 tonsil tonsil NN cord-251986-ajlpb9li 65 13 , , , cord-251986-ajlpb9li 65 14 lung lung NN cord-251986-ajlpb9li 65 15 , , , cord-251986-ajlpb9li 65 16 and and CC cord-251986-ajlpb9li 65 17 small small JJ cord-251986-ajlpb9li 65 18 intestine intestine NN cord-251986-ajlpb9li 65 19 in in IN cord-251986-ajlpb9li 65 20 suckling suckle VBG cord-251986-ajlpb9li 65 21 piglets piglet NNS cord-251986-ajlpb9li 65 22 , , , cord-251986-ajlpb9li 65 23 and and CC cord-251986-ajlpb9li 65 24 then then RB cord-251986-ajlpb9li 65 25 is be VBZ cord-251986-ajlpb9li 65 26 delivered deliver VBN cord-251986-ajlpb9li 65 27 retrogradely retrogradely RB cord-251986-ajlpb9li 65 28 via via IN cord-251986-ajlpb9li 65 29 peripheral peripheral JJ cord-251986-ajlpb9li 65 30 nerves nerve NNS cord-251986-ajlpb9li 65 31 to to IN cord-251986-ajlpb9li 65 32 the the DT cord-251986-ajlpb9li 65 33 medullary medullary JJ cord-251986-ajlpb9li 65 34 neurons neuron NNS cord-251986-ajlpb9li 65 35 in in IN cord-251986-ajlpb9li 65 36 charge charge NN cord-251986-ajlpb9li 65 37 of of IN cord-251986-ajlpb9li 65 38 peristaltic peristaltic JJ cord-251986-ajlpb9li 65 39 function function NN cord-251986-ajlpb9li 65 40 of of IN cord-251986-ajlpb9li 65 41 the the DT cord-251986-ajlpb9li 65 42 digestive digestive JJ cord-251986-ajlpb9li 65 43 tract tract NN cord-251986-ajlpb9li 65 44 , , , cord-251986-ajlpb9li 65 45 resulting result VBG cord-251986-ajlpb9li 65 46 in in IN cord-251986-ajlpb9li 65 47 the the DT cord-251986-ajlpb9li 65 48 so so RB cord-251986-ajlpb9li 65 49 - - HYPH cord-251986-ajlpb9li 65 50 called call VBN cord-251986-ajlpb9li 65 51 vomiting vomit VBG cord-251986-ajlpb9li 65 52 diseases disease NNS cord-251986-ajlpb9li 65 53 . . . cord-251986-ajlpb9li 66 1 18 18 CD cord-251986-ajlpb9li 66 2 , , , cord-251986-ajlpb9li 66 3 19 19 CD cord-251986-ajlpb9li 67 1 The the DT cord-251986-ajlpb9li 67 2 transfer transfer NN cord-251986-ajlpb9li 67 3 of of IN cord-251986-ajlpb9li 67 4 HEV HEV NNP cord-251986-ajlpb9li 67 5 67N 67n CD cord-251986-ajlpb9li 67 6 between between IN cord-251986-ajlpb9li 67 7 neurons neuron NNS cord-251986-ajlpb9li 67 8 has have VBZ cord-251986-ajlpb9li 67 9 been be VBN cord-251986-ajlpb9li 67 10 demonstrated demonstrate VBN cord-251986-ajlpb9li 67 11 by by IN cord-251986-ajlpb9li 67 12 our -PRON- PRP$ cord-251986-ajlpb9li 67 13 previous previous JJ cord-251986-ajlpb9li 67 14 ultrastructural ultrastructural JJ cord-251986-ajlpb9li 67 15 studies study NNS cord-251986-ajlpb9li 67 16 to to TO cord-251986-ajlpb9li 67 17 use use VB cord-251986-ajlpb9li 67 18 the the DT cord-251986-ajlpb9li 67 19 clathrin clathrin NN cord-251986-ajlpb9li 67 20 - - HYPH cord-251986-ajlpb9li 67 21 coatingmediated coatingmediate VBN cord-251986-ajlpb9li 67 22 endocytotic endocytotic JJ cord-251986-ajlpb9li 67 23 / / SYM cord-251986-ajlpb9li 67 24 exocytotic exocytotic JJ cord-251986-ajlpb9li 67 25 pathway pathway NN cord-251986-ajlpb9li 67 26 . . . cord-251986-ajlpb9li 68 1 17 17 CD cord-251986-ajlpb9li 69 1 Similarly similarly RB cord-251986-ajlpb9li 69 2 , , , cord-251986-ajlpb9li 69 3 the the DT cord-251986-ajlpb9li 69 4 trans trans JJ cord-251986-ajlpb9li 69 5 - - JJ cord-251986-ajlpb9li 69 6 synaptic synaptic JJ cord-251986-ajlpb9li 69 7 transfer transfer NN cord-251986-ajlpb9li 69 8 has have VBZ cord-251986-ajlpb9li 69 9 been be VBN cord-251986-ajlpb9li 69 10 reported report VBN cord-251986-ajlpb9li 69 11 for for IN cord-251986-ajlpb9li 69 12 avian avian JJ cord-251986-ajlpb9li 69 13 bronchitis bronchitis NN cord-251986-ajlpb9li 69 14 virus virus NN cord-251986-ajlpb9li 69 15 . . . cord-251986-ajlpb9li 70 1 36 36 CD cord-251986-ajlpb9li 70 2 , , , cord-251986-ajlpb9li 70 3 37 37 CD cord-251986-ajlpb9li 70 4 Intranasal Intranasal NNP cord-251986-ajlpb9li 70 5 inoculation inoculation NN cord-251986-ajlpb9li 70 6 in in IN cord-251986-ajlpb9li 70 7 mice mouse NNS cord-251986-ajlpb9li 70 8 with with IN cord-251986-ajlpb9li 70 9 avian avian JJ cord-251986-ajlpb9li 70 10 influenza influenza NN cord-251986-ajlpb9li 70 11 virus virus NN cord-251986-ajlpb9li 70 12 was be VBD cord-251986-ajlpb9li 70 13 reported report VBN cord-251986-ajlpb9li 70 14 to to TO cord-251986-ajlpb9li 70 15 cause cause VB cord-251986-ajlpb9li 70 16 neural neural JJ cord-251986-ajlpb9li 70 17 infection infection NN cord-251986-ajlpb9li 70 18 besides besides IN cord-251986-ajlpb9li 70 19 bronchitis bronchitis NN cord-251986-ajlpb9li 70 20 or or CC cord-251986-ajlpb9li 70 21 pneumonia pneumonia NN cord-251986-ajlpb9li 70 22 . . . cord-251986-ajlpb9li 71 1 36 36 CD cord-251986-ajlpb9li 71 2 Of of IN cord-251986-ajlpb9li 71 3 interest interest NN cord-251986-ajlpb9li 71 4 , , , cord-251986-ajlpb9li 71 5 viral viral JJ cord-251986-ajlpb9li 71 6 antigens antigen NNS cord-251986-ajlpb9li 71 7 have have VBP cord-251986-ajlpb9li 71 8 been be VBN cord-251986-ajlpb9li 71 9 detected detect VBN cord-251986-ajlpb9li 71 10 in in IN cord-251986-ajlpb9li 71 11 the the DT cord-251986-ajlpb9li 71 12 brainstem brainstem NN cord-251986-ajlpb9li 71 13 , , , cord-251986-ajlpb9li 71 14 where where WRB cord-251986-ajlpb9li 71 15 the the DT cord-251986-ajlpb9li 71 16 infected infected JJ cord-251986-ajlpb9li 71 17 regions region NNS cord-251986-ajlpb9li 71 18 included include VBD cord-251986-ajlpb9li 71 19 the the DT cord-251986-ajlpb9li 71 20 nucleus nucleus NN cord-251986-ajlpb9li 71 21 of of IN cord-251986-ajlpb9li 71 22 the the DT cord-251986-ajlpb9li 71 23 solitary solitary JJ cord-251986-ajlpb9li 71 24 tract tract NN cord-251986-ajlpb9li 71 25 and and CC cord-251986-ajlpb9li 71 26 nucleus nucleus NN cord-251986-ajlpb9li 71 27 ambiguus ambiguus NNP cord-251986-ajlpb9li 71 28 . . . cord-251986-ajlpb9li 72 1 The the DT cord-251986-ajlpb9li 72 2 nucleus nucleus NN cord-251986-ajlpb9li 72 3 of of IN cord-251986-ajlpb9li 72 4 the the DT cord-251986-ajlpb9li 72 5 solitary solitary JJ cord-251986-ajlpb9li 72 6 tract tract NN cord-251986-ajlpb9li 72 7 receives receive VBZ cord-251986-ajlpb9li 72 8 sensory sensory JJ cord-251986-ajlpb9li 72 9 information information NN cord-251986-ajlpb9li 72 10 from from IN cord-251986-ajlpb9li 72 11 the the DT cord-251986-ajlpb9li 72 12 mechanoreceptors mechanoreceptor NNS cord-251986-ajlpb9li 72 13 and and CC cord-251986-ajlpb9li 72 14 chemoreceptors chemoreceptor NNS cord-251986-ajlpb9li 72 15 in in IN cord-251986-ajlpb9li 72 16 the the DT cord-251986-ajlpb9li 72 17 lung lung NN cord-251986-ajlpb9li 72 18 and and CC cord-251986-ajlpb9li 72 19 respiratory respiratory JJ cord-251986-ajlpb9li 72 20 tracts tract NNS cord-251986-ajlpb9li 72 21 , , , cord-251986-ajlpb9li 72 22 [ [ -LRB- cord-251986-ajlpb9li 72 23 40 40 CD cord-251986-ajlpb9li 72 24 ] ] -RRB- cord-251986-ajlpb9li 72 25 [ [ -LRB- cord-251986-ajlpb9li 72 26 41 41 CD cord-251986-ajlpb9li 72 27 ] ] -RRB- cord-251986-ajlpb9li 72 28 [ [ -LRB- cord-251986-ajlpb9li 72 29 42 42 CD cord-251986-ajlpb9li 72 30 ] ] -RRB- cord-251986-ajlpb9li 72 31 while while IN cord-251986-ajlpb9li 72 32 the the DT cord-251986-ajlpb9li 72 33 efferent efferent JJ cord-251986-ajlpb9li 72 34 fibers fiber NNS cord-251986-ajlpb9li 72 35 from from IN cord-251986-ajlpb9li 72 36 the the DT cord-251986-ajlpb9li 72 37 nucleus nucleus NN cord-251986-ajlpb9li 72 38 ambiguus ambiguus NNP cord-251986-ajlpb9li 72 39 and and CC cord-251986-ajlpb9li 72 40 the the DT cord-251986-ajlpb9li 72 41 nucleus nucleus NN cord-251986-ajlpb9li 72 42 of of IN cord-251986-ajlpb9li 72 43 the the DT cord-251986-ajlpb9li 72 44 solitary solitary JJ cord-251986-ajlpb9li 72 45 tract tract NN cord-251986-ajlpb9li 72 46 provide provide VBP cord-251986-ajlpb9li 72 47 innervation innervation NN cord-251986-ajlpb9li 72 48 to to IN cord-251986-ajlpb9li 72 49 airway airway VB cord-251986-ajlpb9li 72 50 smooth smooth JJ cord-251986-ajlpb9li 72 51 muscle muscle NN cord-251986-ajlpb9li 72 52 , , , cord-251986-ajlpb9li 72 53 glands gland NNS cord-251986-ajlpb9li 72 54 , , , cord-251986-ajlpb9li 72 55 and and CC cord-251986-ajlpb9li 72 56 blood blood NN cord-251986-ajlpb9li 72 57 vessels vessel NNS cord-251986-ajlpb9li 72 58 . . . cord-251986-ajlpb9li 73 1 Such such JJ cord-251986-ajlpb9li 73 2 neuroanatomic neuroanatomic JJ cord-251986-ajlpb9li 73 3 interconnections interconnection NNS cord-251986-ajlpb9li 73 4 indicate indicate VBP cord-251986-ajlpb9li 73 5 that that IN cord-251986-ajlpb9li 73 6 the the DT cord-251986-ajlpb9li 73 7 death death NN cord-251986-ajlpb9li 73 8 of of IN cord-251986-ajlpb9li 73 9 infected infected JJ cord-251986-ajlpb9li 73 10 animals animal NNS cord-251986-ajlpb9li 73 11 or or CC cord-251986-ajlpb9li 73 12 patients patient NNS cord-251986-ajlpb9li 73 13 may may MD cord-251986-ajlpb9li 73 14 be be VB cord-251986-ajlpb9li 73 15 due due JJ cord-251986-ajlpb9li 73 16 to to IN cord-251986-ajlpb9li 73 17 the the DT cord-251986-ajlpb9li 73 18 dysfunction dysfunction NN cord-251986-ajlpb9li 73 19 of of IN cord-251986-ajlpb9li 73 20 the the DT cord-251986-ajlpb9li 73 21 cardiorespiratory cardiorespiratory JJ cord-251986-ajlpb9li 73 22 center center NN cord-251986-ajlpb9li 73 23 in in IN cord-251986-ajlpb9li 73 24 the the DT cord-251986-ajlpb9li 73 25 brainstem brainstem NN cord-251986-ajlpb9li 73 26 . . . cord-251986-ajlpb9li 74 1 11 11 CD cord-251986-ajlpb9li 74 2 , , , cord-251986-ajlpb9li 74 3 30 30 CD cord-251986-ajlpb9li 74 4 , , , cord-251986-ajlpb9li 74 5 36 36 CD cord-251986-ajlpb9li 74 6 Taken take VBN cord-251986-ajlpb9li 74 7 together together RB cord-251986-ajlpb9li 74 8 , , , cord-251986-ajlpb9li 74 9 the the DT cord-251986-ajlpb9li 74 10 neuroinvasive neuroinvasive JJ cord-251986-ajlpb9li 74 11 propensity propensity NN cord-251986-ajlpb9li 74 12 has have VBZ cord-251986-ajlpb9li 74 13 been be VBN cord-251986-ajlpb9li 74 14 demonstrated demonstrate VBN cord-251986-ajlpb9li 74 15 as as IN cord-251986-ajlpb9li 74 16 a a DT cord-251986-ajlpb9li 74 17 common common JJ cord-251986-ajlpb9li 74 18 feature feature NN cord-251986-ajlpb9li 74 19 of of IN cord-251986-ajlpb9li 74 20 CoVs CoVs NNP cord-251986-ajlpb9li 74 21 . . . cord-251986-ajlpb9li 75 1 In in IN cord-251986-ajlpb9li 75 2 light light NN cord-251986-ajlpb9li 75 3 of of IN cord-251986-ajlpb9li 75 4 the the DT cord-251986-ajlpb9li 75 5 high high JJ cord-251986-ajlpb9li 75 6 similarity similarity NN cord-251986-ajlpb9li 75 7 between between IN cord-251986-ajlpb9li 75 8 SARS SARS NNP cord-251986-ajlpb9li 75 9 - - HYPH cord-251986-ajlpb9li 75 10 CoV CoV NNP cord-251986-ajlpb9li 75 11 and and CC cord-251986-ajlpb9li 75 12 SARS SARS NNP cord-251986-ajlpb9li 75 13 - - HYPH cord-251986-ajlpb9li 75 14 CoV2 CoV2 NNP cord-251986-ajlpb9li 75 15 , , , cord-251986-ajlpb9li 75 16 it -PRON- PRP cord-251986-ajlpb9li 75 17 is be VBZ cord-251986-ajlpb9li 75 18 quite quite RB cord-251986-ajlpb9li 75 19 likely likely JJ cord-251986-ajlpb9li 75 20 that that IN cord-251986-ajlpb9li 75 21 SARS SARS NNP cord-251986-ajlpb9li 75 22 - - HYPH cord-251986-ajlpb9li 75 23 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 75 24 also also RB cord-251986-ajlpb9li 75 25 possesses possess VBZ cord-251986-ajlpb9li 75 26 a a DT cord-251986-ajlpb9li 75 27 similar similar JJ cord-251986-ajlpb9li 75 28 potential potential NN cord-251986-ajlpb9li 75 29 . . . cord-251986-ajlpb9li 76 1 Based base VBN cord-251986-ajlpb9li 76 2 on on IN cord-251986-ajlpb9li 76 3 an an DT cord-251986-ajlpb9li 76 4 epidemiological epidemiological JJ cord-251986-ajlpb9li 76 5 survey survey NN cord-251986-ajlpb9li 76 6 on on IN cord-251986-ajlpb9li 76 7 COVID-19 COVID-19 NNP cord-251986-ajlpb9li 76 8 , , , cord-251986-ajlpb9li 76 9 the the DT cord-251986-ajlpb9li 76 10 median median JJ cord-251986-ajlpb9li 76 11 time time NN cord-251986-ajlpb9li 76 12 from from IN cord-251986-ajlpb9li 76 13 the the DT cord-251986-ajlpb9li 76 14 first first JJ cord-251986-ajlpb9li 76 15 symptom symptom NN cord-251986-ajlpb9li 76 16 to to IN cord-251986-ajlpb9li 76 17 dyspnea dyspnea NN cord-251986-ajlpb9li 76 18 was be VBD cord-251986-ajlpb9li 76 19 5.0 5.0 CD cord-251986-ajlpb9li 76 20 days day NNS cord-251986-ajlpb9li 76 21 , , , cord-251986-ajlpb9li 76 22 to to IN cord-251986-ajlpb9li 76 23 hospital hospital NN cord-251986-ajlpb9li 76 24 admission admission NN cord-251986-ajlpb9li 76 25 was be VBD cord-251986-ajlpb9li 76 26 7.0 7.0 CD cord-251986-ajlpb9li 76 27 days day NNS cord-251986-ajlpb9li 76 28 , , , cord-251986-ajlpb9li 76 29 and and CC cord-251986-ajlpb9li 76 30 to to IN cord-251986-ajlpb9li 76 31 the the DT cord-251986-ajlpb9li 76 32 intensive intensive JJ cord-251986-ajlpb9li 76 33 care care NN cord-251986-ajlpb9li 76 34 was be VBD cord-251986-ajlpb9li 76 35 8.0 8.0 CD cord-251986-ajlpb9li 76 36 days day NNS cord-251986-ajlpb9li 76 37 . . . cord-251986-ajlpb9li 77 1 10 10 CD cord-251986-ajlpb9li 78 1 Therefore therefore RB cord-251986-ajlpb9li 78 2 , , , cord-251986-ajlpb9li 78 3 the the DT cord-251986-ajlpb9li 78 4 latency latency NN cord-251986-ajlpb9li 78 5 period period NN cord-251986-ajlpb9li 78 6 may may MD cord-251986-ajlpb9li 78 7 be be VB cord-251986-ajlpb9li 78 8 enough enough JJ cord-251986-ajlpb9li 78 9 for for IN cord-251986-ajlpb9li 78 10 the the DT cord-251986-ajlpb9li 78 11 virus virus NN cord-251986-ajlpb9li 78 12 to to TO cord-251986-ajlpb9li 78 13 enter enter VB cord-251986-ajlpb9li 78 14 and and CC cord-251986-ajlpb9li 78 15 destroy destroy VB cord-251986-ajlpb9li 78 16 the the DT cord-251986-ajlpb9li 78 17 medullary medullary JJ cord-251986-ajlpb9li 78 18 neurons neuron NNS cord-251986-ajlpb9li 78 19 . . . cord-251986-ajlpb9li 79 1 As as IN cord-251986-ajlpb9li 79 2 a a DT cord-251986-ajlpb9li 79 3 matter matter NN cord-251986-ajlpb9li 79 4 of of IN cord-251986-ajlpb9li 79 5 fact fact NN cord-251986-ajlpb9li 79 6 , , , cord-251986-ajlpb9li 79 7 the the DT cord-251986-ajlpb9li 79 8 previous previous JJ cord-251986-ajlpb9li 79 9 studies study NNS cord-251986-ajlpb9li 79 10 2,14 2,14 CD cord-251986-ajlpb9li 79 11 - - SYM cord-251986-ajlpb9li 79 12 15 15 CD cord-251986-ajlpb9li 79 13 mentioned mention VBN cord-251986-ajlpb9li 79 14 above above RB cord-251986-ajlpb9li 79 15 has have VBZ cord-251986-ajlpb9li 79 16 reported report VBN cord-251986-ajlpb9li 79 17 that that IN cord-251986-ajlpb9li 79 18 some some DT cord-251986-ajlpb9li 79 19 patients patient NNS cord-251986-ajlpb9li 79 20 infected infect VBN cord-251986-ajlpb9li 79 21 with with IN cord-251986-ajlpb9li 79 22 SARS SARS NNP cord-251986-ajlpb9li 79 23 - - HYPH cord-251986-ajlpb9li 79 24 CoV-2 CoV-2 NNP cord-251986-ajlpb9li 79 25 did do VBD cord-251986-ajlpb9li 79 26 show show VB cord-251986-ajlpb9li 79 27 neurologic neurologic JJ cord-251986-ajlpb9li 79 28 signs sign NNS cord-251986-ajlpb9li 79 29 such such JJ cord-251986-ajlpb9li 79 30 as as IN cord-251986-ajlpb9li 79 31 headache headache NN cord-251986-ajlpb9li 79 32 ( ( -LRB- cord-251986-ajlpb9li 79 33 about about RB cord-251986-ajlpb9li 79 34 8 8 CD cord-251986-ajlpb9li 79 35 % % NN cord-251986-ajlpb9li 79 36 ) ) -RRB- cord-251986-ajlpb9li 79 37 , , , cord-251986-ajlpb9li 79 38 nausea nausea NN cord-251986-ajlpb9li 79 39 and and CC cord-251986-ajlpb9li 79 40 vomiting vomiting NN cord-251986-ajlpb9li 79 41 ( ( -LRB- cord-251986-ajlpb9li 79 42 1 1 CD cord-251986-ajlpb9li 79 43 % % NN cord-251986-ajlpb9li 79 44 ) ) -RRB- cord-251986-ajlpb9li 79 45 . . . cord-251986-ajlpb9li 80 1 More more RBR cord-251986-ajlpb9li 80 2 recently recently RB cord-251986-ajlpb9li 80 3 , , , cord-251986-ajlpb9li 80 4 one one CD cord-251986-ajlpb9li 80 5 study study NN cord-251986-ajlpb9li 80 6 on on IN cord-251986-ajlpb9li 80 7 214 214 CD cord-251986-ajlpb9li 80 8 COVID-19 covid-19 CD cord-251986-ajlpb9li 80 9 patients patient NNS cord-251986-ajlpb9li 80 10 by by IN cord-251986-ajlpb9li 80 11 Mao Mao NNP cord-251986-ajlpb9li 80 12 et et NNP cord-251986-ajlpb9li 80 13 al al NNP cord-251986-ajlpb9li 80 14 . . . cord-251986-ajlpb9li 81 1 43 43 CD cord-251986-ajlpb9li 81 2 further further RB cord-251986-ajlpb9li 81 3 found find VBD cord-251986-ajlpb9li 81 4 that that IN cord-251986-ajlpb9li 81 5 about about IN cord-251986-ajlpb9li 81 6 88 88 CD cord-251986-ajlpb9li 81 7 % % NN cord-251986-ajlpb9li 81 8 ( ( -LRB- cord-251986-ajlpb9li 81 9 78/88 78/88 CD cord-251986-ajlpb9li 81 10 ) ) -RRB- cord-251986-ajlpb9li 81 11 among among IN cord-251986-ajlpb9li 81 12 the the DT cord-251986-ajlpb9li 81 13 severe severe JJ cord-251986-ajlpb9li 81 14 patients patient NNS cord-251986-ajlpb9li 81 15 displayed display VBD cord-251986-ajlpb9li 81 16 neurologic neurologic JJ cord-251986-ajlpb9li 81 17 manifestations manifestation NNS cord-251986-ajlpb9li 81 18 including include VBG cord-251986-ajlpb9li 81 19 acute acute JJ cord-251986-ajlpb9li 81 20 cerebrovascular cerebrovascular JJ cord-251986-ajlpb9li 81 21 diseases disease NNS cord-251986-ajlpb9li 81 22 and and CC cord-251986-ajlpb9li 81 23 impaired impaired JJ cord-251986-ajlpb9li 81 24 consciousness consciousness NN cord-251986-ajlpb9li 81 25 . . . cord-251986-ajlpb9li 82 1 Therefore therefore RB cord-251986-ajlpb9li 82 2 , , , cord-251986-ajlpb9li 82 3 awareness awareness NN cord-251986-ajlpb9li 82 4 of of IN cord-251986-ajlpb9li 82 5 the the DT cord-251986-ajlpb9li 82 6 possible possible JJ cord-251986-ajlpb9li 82 7 neuroinvasion neuroinvasion NN cord-251986-ajlpb9li 82 8 may may MD cord-251986-ajlpb9li 82 9 have have VB cord-251986-ajlpb9li 82 10 a a DT cord-251986-ajlpb9li 82 11 guiding guide VBG cord-251986-ajlpb9li 82 12 significance significance NN cord-251986-ajlpb9li 82 13 for for IN cord-251986-ajlpb9li 82 14 the the DT cord-251986-ajlpb9li 82 15 prevention prevention NN cord-251986-ajlpb9li 82 16 and and CC cord-251986-ajlpb9li 82 17 treatment treatment NN cord-251986-ajlpb9li 82 18 of of IN cord-251986-ajlpb9li 82 19 the the DT cord-251986-ajlpb9li 82 20 SARS SARS NNP cord-251986-ajlpb9li 82 21 - - HYPH cord-251986-ajlpb9li 82 22 CoV-2-induced cov-2-induce VBN cord-251986-ajlpb9li 82 23 respiratory respiratory JJ cord-251986-ajlpb9li 82 24 failure failure NN cord-251986-ajlpb9li 82 25 . . . cord-251986-ajlpb9li 83 1 http://orcid.org/0000-0002-2884-9829 http://orcid.org/0000-0002-2884-9829 NNP cord-251986-ajlpb9li 83 2 Mechanisms Mechanisms NNPS cord-251986-ajlpb9li 83 3 of of IN cord-251986-ajlpb9li 83 4 host host NN cord-251986-ajlpb9li 83 5 defense defense NN cord-251986-ajlpb9li 83 6 following follow VBG cord-251986-ajlpb9li 83 7 severe severe JJ cord-251986-ajlpb9li 83 8 acute acute JJ cord-251986-ajlpb9li 83 9 respiratory respiratory JJ cord-251986-ajlpb9li 83 10 syndrome syndrome NN cord-251986-ajlpb9li 83 11 - - HYPH cord-251986-ajlpb9li 83 12 coronavirus coronavirus NN cord-251986-ajlpb9li 83 13 ( ( -LRB- cord-251986-ajlpb9li 83 14 SARS SARS NNP cord-251986-ajlpb9li 83 15 - - HYPH cord-251986-ajlpb9li 83 16 CoV CoV NNP cord-251986-ajlpb9li 83 17 ) ) -RRB- cord-251986-ajlpb9li 83 18 pulmonary pulmonary JJ cord-251986-ajlpb9li 83 19 infection infection NN cord-251986-ajlpb9li 83 20 of of IN cord-251986-ajlpb9li 83 21 mice mouse NNS cord-251986-ajlpb9li 83 22 Clinical clinical JJ cord-251986-ajlpb9li 83 23 features feature NNS cord-251986-ajlpb9li 83 24 of of IN cord-251986-ajlpb9li 83 25 patients patient NNS cord-251986-ajlpb9li 83 26 infected infect VBN cord-251986-ajlpb9li 83 27 with with IN cord-251986-ajlpb9li 83 28 2019 2019 CD cord-251986-ajlpb9li 83 29 novel novel JJ cord-251986-ajlpb9li 83 30 coronavirus coronavirus NN cord-251986-ajlpb9li 83 31 in in IN cord-251986-ajlpb9li 83 32 Wuhan Wuhan NNP cord-251986-ajlpb9li 83 33 Measures Measures NNP cord-251986-ajlpb9li 83 34 for for IN cord-251986-ajlpb9li 83 35 diagnosing diagnose VBG cord-251986-ajlpb9li 83 36 and and CC cord-251986-ajlpb9li 83 37 treating treat VBG cord-251986-ajlpb9li 83 38 infections infection NNS cord-251986-ajlpb9li 83 39 by by IN cord-251986-ajlpb9li 83 40 a a DT cord-251986-ajlpb9li 83 41 novel novel JJ cord-251986-ajlpb9li 83 42 coronavirus coronavirus NN cord-251986-ajlpb9li 83 43 responsible responsible JJ cord-251986-ajlpb9li 83 44 for for IN cord-251986-ajlpb9li 83 45 a a DT cord-251986-ajlpb9li 83 46 pneumonia pneumonia NN cord-251986-ajlpb9li 83 47 outbreak outbreak NN cord-251986-ajlpb9li 83 48 originating originate VBG cord-251986-ajlpb9li 83 49 in in IN cord-251986-ajlpb9li 83 50 Wuhan Wuhan NNP cord-251986-ajlpb9li 83 51 , , , cord-251986-ajlpb9li 83 52 China China NNP cord-251986-ajlpb9li 83 53 . . . cord-251986-ajlpb9li 84 1 Microbes microbe NNS cord-251986-ajlpb9li 84 2 Infect infect VBP cord-251986-ajlpb9li 84 3 From from IN cord-251986-ajlpb9li 84 4 SARS SARS NNP cord-251986-ajlpb9li 84 5 to to IN cord-251986-ajlpb9li 84 6 MERS MERS NNP cord-251986-ajlpb9li 84 7 , , , cord-251986-ajlpb9li 84 8 thrusting thrust VBG cord-251986-ajlpb9li 84 9 coronaviruses coronaviruse NNS cord-251986-ajlpb9li 84 10 into into IN cord-251986-ajlpb9li 84 11 the the DT cord-251986-ajlpb9li 84 12 spotlight spotlight NN cord-251986-ajlpb9li 84 13 Genomic genomic JJ cord-251986-ajlpb9li 84 14 characterisation characterisation NN cord-251986-ajlpb9li 84 15 and and CC cord-251986-ajlpb9li 84 16 epidemiology epidemiology NN cord-251986-ajlpb9li 84 17 of of IN cord-251986-ajlpb9li 84 18 2019 2019 CD cord-251986-ajlpb9li 84 19 novel novel JJ cord-251986-ajlpb9li 84 20 coronavirus coronavirus NN cord-251986-ajlpb9li 84 21 : : : cord-251986-ajlpb9li 84 22 implications implication NNS cord-251986-ajlpb9li 84 23 for for IN cord-251986-ajlpb9li 84 24 virus virus NN cord-251986-ajlpb9li 84 25 origins origin NNS cord-251986-ajlpb9li 84 26 and and CC cord-251986-ajlpb9li 84 27 receptor receptor NN cord-251986-ajlpb9li 84 28 binding bind VBG cord-251986-ajlpb9li 84 29 Receptor receptor NN cord-251986-ajlpb9li 84 30 recognition recognition NN cord-251986-ajlpb9li 84 31 by by IN cord-251986-ajlpb9li 84 32 novel novel JJ cord-251986-ajlpb9li 84 33 coronavirus coronavirus NN cord-251986-ajlpb9li 84 34 from from IN cord-251986-ajlpb9li 84 35 Wuhan Wuhan NNP cord-251986-ajlpb9li 84 36 : : : cord-251986-ajlpb9li 84 37 an an DT cord-251986-ajlpb9li 84 38 analysis analysis NN cord-251986-ajlpb9li 84 39 based base VBN cord-251986-ajlpb9li 84 40 on on IN cord-251986-ajlpb9li 84 41 decade decade NN cord-251986-ajlpb9li 84 42 - - HYPH cord-251986-ajlpb9li 84 43 long long JJ cord-251986-ajlpb9li 84 44 structural structural JJ cord-251986-ajlpb9li 84 45 studies study NNS cord-251986-ajlpb9li 84 46 of of IN cord-251986-ajlpb9li 84 47 SARS SARS NNP cord-251986-ajlpb9li 84 48 Cryo Cryo NNP cord-251986-ajlpb9li 84 49 - - HYPH cord-251986-ajlpb9li 84 50 EM EM NNP cord-251986-ajlpb9li 84 51 structures structure NNS cord-251986-ajlpb9li 84 52 of of IN cord-251986-ajlpb9li 84 53 MERS MERS NNP cord-251986-ajlpb9li 84 54 - - HYPH cord-251986-ajlpb9li 84 55 CoV CoV NNP cord-251986-ajlpb9li 84 56 and and CC cord-251986-ajlpb9li 84 57 SARS SARS NNP cord-251986-ajlpb9li 84 58 - - HYPH cord-251986-ajlpb9li 84 59 CoV CoV NNP cord-251986-ajlpb9li 84 60 spike spike NN cord-251986-ajlpb9li 84 61 glycoproteins glycoprotein NNS cord-251986-ajlpb9li 84 62 reveal reveal VBP cord-251986-ajlpb9li 84 63 the the DT cord-251986-ajlpb9li 84 64 dynamic dynamic JJ cord-251986-ajlpb9li 84 65 receptor receptor NN cord-251986-ajlpb9li 84 66 binding bind VBG cord-251986-ajlpb9li 84 67 domains domain NNS cord-251986-ajlpb9li 84 68 Coronavirus Coronavirus NNP cord-251986-ajlpb9li 84 69 spike spike NN cord-251986-ajlpb9li 84 70 protein protein NN cord-251986-ajlpb9li 84 71 and and CC cord-251986-ajlpb9li 84 72 tropism tropism NN cord-251986-ajlpb9li 84 73 changes change VBZ cord-251986-ajlpb9li 84 74 Coronavirus Coronavirus NNP cord-251986-ajlpb9li 84 75 infection infection NN cord-251986-ajlpb9li 84 76 of of IN cord-251986-ajlpb9li 84 77 rat rat NN cord-251986-ajlpb9li 84 78 dorsal dorsal JJ cord-251986-ajlpb9li 84 79 root root NN cord-251986-ajlpb9li 84 80 ganglia ganglion NNS cord-251986-ajlpb9li 84 81 : : : cord-251986-ajlpb9li 84 82 ultrastructural ultrastructural JJ cord-251986-ajlpb9li 84 83 characterization characterization NN cord-251986-ajlpb9li 84 84 of of IN cord-251986-ajlpb9li 84 85 viral viral JJ cord-251986-ajlpb9li 84 86 replication replication NN cord-251986-ajlpb9li 84 87 , , , cord-251986-ajlpb9li 84 88 transfer transfer NN cord-251986-ajlpb9li 84 89 , , , cord-251986-ajlpb9li 84 90 and and CC cord-251986-ajlpb9li 84 91 the the DT cord-251986-ajlpb9li 84 92 early early JJ cord-251986-ajlpb9li 84 93 response response NN cord-251986-ajlpb9li 84 94 of of IN cord-251986-ajlpb9li 84 95 satellite satellite NN cord-251986-ajlpb9li 84 96 cells cell NNS cord-251986-ajlpb9li 84 97 Clinical clinical JJ cord-251986-ajlpb9li 84 98 characteristics characteristic NNS cord-251986-ajlpb9li 84 99 of of IN cord-251986-ajlpb9li 84 100 138 138 CD cord-251986-ajlpb9li 84 101 hospitalized hospitalize VBN cord-251986-ajlpb9li 84 102 patients patient NNS cord-251986-ajlpb9li 84 103 with with IN cord-251986-ajlpb9li 84 104 2019 2019 CD cord-251986-ajlpb9li 84 105 novel novel JJ cord-251986-ajlpb9li 84 106 coronavirus coronavirus NN cord-251986-ajlpb9li 84 107 - - HYPH cord-251986-ajlpb9li 84 108 infected infect VBN cord-251986-ajlpb9li 84 109 pneumonia pneumonia NN cord-251986-ajlpb9li 84 110 in in IN cord-251986-ajlpb9li 84 111 Wuhan Wuhan NNP cord-251986-ajlpb9li 84 112 , , , cord-251986-ajlpb9li 84 113 China China NNP cord-251986-ajlpb9li 84 114 Novel Novel NNP cord-251986-ajlpb9li 84 115 coronavirus coronavirus NN cord-251986-ajlpb9li 84 116 is be VBZ cord-251986-ajlpb9li 84 117 putting put VBG cord-251986-ajlpb9li 84 118 the the DT cord-251986-ajlpb9li 84 119 whole whole JJ cord-251986-ajlpb9li 84 120 world world NN cord-251986-ajlpb9li 84 121 on on IN cord-251986-ajlpb9li 84 122 alert alert JJ cord-251986-ajlpb9li 84 123 Epidemiological epidemiological JJ cord-251986-ajlpb9li 84 124 and and CC cord-251986-ajlpb9li 84 125 clinical clinical JJ cord-251986-ajlpb9li 84 126 characteristics characteristic NNS cord-251986-ajlpb9li 84 127 of of IN cord-251986-ajlpb9li 84 128 99 99 CD cord-251986-ajlpb9li 84 129 cases case NNS cord-251986-ajlpb9li 84 130 of of IN cord-251986-ajlpb9li 84 131 2019 2019 CD cord-251986-ajlpb9li 84 132 novel novel JJ cord-251986-ajlpb9li 84 133 coronavirus coronavirus NN cord-251986-ajlpb9li 84 134 pneumonia pneumonia NN cord-251986-ajlpb9li 84 135 in in IN cord-251986-ajlpb9li 84 136 Wuhan Wuhan NNP cord-251986-ajlpb9li 84 137 , , , cord-251986-ajlpb9li 84 138 China China NNP cord-251986-ajlpb9li 84 139 : : : cord-251986-ajlpb9li 84 140 a a DT cord-251986-ajlpb9li 84 141 descriptive descriptive JJ cord-251986-ajlpb9li 84 142 study study NN cord-251986-ajlpb9li 85 1 Middle Middle NNP cord-251986-ajlpb9li 85 2 East East NNP cord-251986-ajlpb9li 85 3 respiratory respiratory JJ cord-251986-ajlpb9li 85 4 syndrome syndrome NN cord-251986-ajlpb9li 85 5 coronavirus coronavirus NN cord-251986-ajlpb9li 85 6 causes cause VBZ cord-251986-ajlpb9li 85 7 multiple multiple JJ cord-251986-ajlpb9li 85 8 organ organ NN cord-251986-ajlpb9li 85 9 damage damage NN cord-251986-ajlpb9li 85 10 and and CC cord-251986-ajlpb9li 85 11 lethal lethal JJ cord-251986-ajlpb9li 85 12 disease disease NN cord-251986-ajlpb9li 85 13 in in IN cord-251986-ajlpb9li 85 14 mice mouse NNS cord-251986-ajlpb9li 85 15 transgenic transgenic JJ cord-251986-ajlpb9li 85 16 for for IN cord-251986-ajlpb9li 85 17 human human JJ cord-251986-ajlpb9li 85 18 dipeptidyl dipeptidyl JJ cord-251986-ajlpb9li 85 19 peptidase peptidase NN cord-251986-ajlpb9li 85 20 4 4 CD cord-251986-ajlpb9li 85 21 Neurotropism Neurotropism NNP cord-251986-ajlpb9li 85 22 of of IN cord-251986-ajlpb9li 85 23 human human JJ cord-251986-ajlpb9li 85 24 coronavirus coronavirus NN cord-251986-ajlpb9li 85 25 229E 229e CD cord-251986-ajlpb9li 86 1 Axonal axonal JJ cord-251986-ajlpb9li 86 2 transport transport NN cord-251986-ajlpb9li 86 3 enables enable VBZ cord-251986-ajlpb9li 86 4 neuron neuron NN cord-251986-ajlpb9li 86 5 - - HYPH cord-251986-ajlpb9li 86 6 to to IN cord-251986-ajlpb9li 86 7 - - HYPH cord-251986-ajlpb9li 86 8 neuron neuron NN cord-251986-ajlpb9li 86 9 propagation propagation NN cord-251986-ajlpb9li 86 10 of of IN cord-251986-ajlpb9li 86 11 human human JJ cord-251986-ajlpb9li 86 12 coronavirus coronavirus NN cord-251986-ajlpb9li 86 13 OC43 OC43 NNP cord-251986-ajlpb9li 86 14 Hepatitis Hepatitis NNP cord-251986-ajlpb9li 86 15 E E NNP cord-251986-ajlpb9li 86 16 virus virus NN cord-251986-ajlpb9li 86 17 infects infect VBZ cord-251986-ajlpb9li 86 18 neurons neuron NNS cord-251986-ajlpb9li 86 19 and and CC cord-251986-ajlpb9li 86 20 brains brain NNS cord-251986-ajlpb9li 86 21 Neurotropic Neurotropic NNP cord-251986-ajlpb9li 86 22 virus virus NN cord-251986-ajlpb9li 86 23 tracing tracing NN cord-251986-ajlpb9li 86 24 suggests suggest VBZ cord-251986-ajlpb9li 86 25 a a DT cord-251986-ajlpb9li 86 26 membranous membranous JJ cord-251986-ajlpb9li 86 27 - - HYPH cord-251986-ajlpb9li 86 28 coating coating NN cord-251986-ajlpb9li 86 29 - - HYPH cord-251986-ajlpb9li 86 30 mediated mediate VBN cord-251986-ajlpb9li 86 31 mechanism mechanism NN cord-251986-ajlpb9li 86 32 for for IN cord-251986-ajlpb9li 86 33 transsynaptic transsynaptic JJ cord-251986-ajlpb9li 86 34 communication communication NN cord-251986-ajlpb9li 86 35 Characteristics characteristic NNS cord-251986-ajlpb9li 86 36 of of IN cord-251986-ajlpb9li 86 37 a a DT cord-251986-ajlpb9li 86 38 coronavirus coronavirus NN cord-251986-ajlpb9li 86 39 ( ( -LRB- cord-251986-ajlpb9li 86 40 strain strain NN cord-251986-ajlpb9li 86 41 67N 67n CD cord-251986-ajlpb9li 86 42 ) ) -RRB- cord-251986-ajlpb9li 86 43 of of IN cord-251986-ajlpb9li 86 44 pigs pig NNS cord-251986-ajlpb9li 86 45 Immunofluorescence Immunofluorescence NNP cord-251986-ajlpb9li 86 46 studies study NNS cord-251986-ajlpb9li 86 47 on on IN cord-251986-ajlpb9li 86 48 the the DT cord-251986-ajlpb9li 86 49 pathogenesis pathogenesis NN cord-251986-ajlpb9li 86 50 of of IN cord-251986-ajlpb9li 86 51 hemagglutinating hemagglutinate VBG cord-251986-ajlpb9li 86 52 encephalomyelitis encephalomyelitis NN cord-251986-ajlpb9li 86 53 virus virus NN cord-251986-ajlpb9li 86 54 infection infection NN cord-251986-ajlpb9li 86 55 in in IN cord-251986-ajlpb9li 86 56 pigs pig NNS cord-251986-ajlpb9li 86 57 after after IN cord-251986-ajlpb9li 86 58 oronasal oronasal NN cord-251986-ajlpb9li 86 59 inoculation inoculation NN cord-251986-ajlpb9li 86 60 Exploring explore VBG cord-251986-ajlpb9li 86 61 the the DT cord-251986-ajlpb9li 86 62 pathogenesis pathogenesis NN cord-251986-ajlpb9li 86 63 of of IN cord-251986-ajlpb9li 86 64 severe severe JJ cord-251986-ajlpb9li 86 65 acute acute JJ cord-251986-ajlpb9li 86 66 respiratory respiratory JJ cord-251986-ajlpb9li 86 67 syndrome syndrome NN cord-251986-ajlpb9li 86 68 ( ( -LRB- cord-251986-ajlpb9li 86 69 SARS SARS NNP cord-251986-ajlpb9li 86 70 ) ) -RRB- cord-251986-ajlpb9li 86 71 : : : cord-251986-ajlpb9li 86 72 the the DT cord-251986-ajlpb9li 86 73 tissue tissue NN cord-251986-ajlpb9li 86 74 distribution distribution NN cord-251986-ajlpb9li 86 75 of of IN cord-251986-ajlpb9li 86 76 the the DT cord-251986-ajlpb9li 86 77 coronavirus coronavirus NN cord-251986-ajlpb9li 86 78 ( ( -LRB- cord-251986-ajlpb9li 86 79 SARS SARS NNP cord-251986-ajlpb9li 86 80 - - HYPH cord-251986-ajlpb9li 86 81 CoV CoV NNP cord-251986-ajlpb9li 86 82 ) ) -RRB- cord-251986-ajlpb9li 86 83 and and CC cord-251986-ajlpb9li 86 84 its -PRON- PRP$ cord-251986-ajlpb9li 86 85 putative putative JJ cord-251986-ajlpb9li 86 86 receptor receptor NN cord-251986-ajlpb9li 86 87 , , , cord-251986-ajlpb9li 86 88 angiotensin angiotensin NN cord-251986-ajlpb9li 86 89 - - HYPH cord-251986-ajlpb9li 86 90 converting convert VBG cord-251986-ajlpb9li 86 91 enzyme enzyme NN cord-251986-ajlpb9li 86 92 2 2 CD cord-251986-ajlpb9li 86 93 ( ( -LRB- cord-251986-ajlpb9li 86 94 ACE2 ACE2 NNP cord-251986-ajlpb9li 86 95 ) ) -RRB- cord-251986-ajlpb9li 87 1 Quantitative quantitative JJ cord-251986-ajlpb9li 87 2 temporal temporal JJ cord-251986-ajlpb9li 87 3 - - HYPH cord-251986-ajlpb9li 87 4 spatial spatial JJ cord-251986-ajlpb9li 87 5 distribution distribution NN cord-251986-ajlpb9li 87 6 of of IN cord-251986-ajlpb9li 87 7 severe severe JJ cord-251986-ajlpb9li 87 8 acute acute JJ cord-251986-ajlpb9li 87 9 respiratory respiratory JJ cord-251986-ajlpb9li 87 10 syndromeassociated syndromeassociate VBN cord-251986-ajlpb9li 87 11 coronavirus coronavirus NN cord-251986-ajlpb9li 87 12 ( ( -LRB- cord-251986-ajlpb9li 87 13 SARS SARS NNP cord-251986-ajlpb9li 87 14 - - HYPH cord-251986-ajlpb9li 87 15 CoV CoV NNP cord-251986-ajlpb9li 87 16 ) ) -RRB- cord-251986-ajlpb9li 87 17 in in IN cord-251986-ajlpb9li 87 18 post post JJ cord-251986-ajlpb9li 87 19 - - JJ cord-251986-ajlpb9li 87 20 mortem mortem JJ cord-251986-ajlpb9li 87 21 tissues tissue NNS cord-251986-ajlpb9li 87 22 Cleavage cleavage NN cord-251986-ajlpb9li 87 23 of of IN cord-251986-ajlpb9li 87 24 the the DT cord-251986-ajlpb9li 87 25 SARS SARS NNP cord-251986-ajlpb9li 87 26 coronavirus coronavirus NN cord-251986-ajlpb9li 87 27 spike spike NN cord-251986-ajlpb9li 87 28 glycoprotein glycoprotein NN cord-251986-ajlpb9li 87 29 by by IN cord-251986-ajlpb9li 87 30 airway airway NN cord-251986-ajlpb9li 87 31 proteases protease NNS cord-251986-ajlpb9li 87 32 enhances enhance VBZ cord-251986-ajlpb9li 87 33 virus virus NN cord-251986-ajlpb9li 87 34 entry entry NN cord-251986-ajlpb9li 87 35 into into IN cord-251986-ajlpb9li 87 36 human human JJ cord-251986-ajlpb9li 87 37 bronchial bronchial JJ cord-251986-ajlpb9li 87 38 epithelial epithelial JJ cord-251986-ajlpb9li 87 39 cells cell NNS cord-251986-ajlpb9li 87 40 in in IN cord-251986-ajlpb9li 87 41 vitro vitro FW cord-251986-ajlpb9li 87 42 A a DT cord-251986-ajlpb9li 87 43 novel novel JJ cord-251986-ajlpb9li 87 44 angiotensinconverting angiotensinconverting NN cord-251986-ajlpb9li 87 45 enzyme enzyme NN cord-251986-ajlpb9li 87 46 - - HYPH cord-251986-ajlpb9li 87 47 related relate VBN cord-251986-ajlpb9li 87 48 carboxypeptidase carboxypeptidase NN cord-251986-ajlpb9li 87 49 ( ( -LRB- cord-251986-ajlpb9li 87 50 ACE2 ACE2 NNP cord-251986-ajlpb9li 87 51 ) ) -RRB- cord-251986-ajlpb9li 88 1 converts convert VBZ cord-251986-ajlpb9li 88 2 angiotensin angiotensin NN cord-251986-ajlpb9li 88 3 I -PRON- PRP cord-251986-ajlpb9li 88 4 to to IN cord-251986-ajlpb9li 88 5 angiotensin angiotensin NN cord-251986-ajlpb9li 88 6 1 1 CD cord-251986-ajlpb9li 88 7 - - SYM cord-251986-ajlpb9li 88 8 9 9 CD cord-251986-ajlpb9li 88 9 Quantitative Quantitative NNP cord-251986-ajlpb9li 88 10 mRNA mRNA NNP cord-251986-ajlpb9li 88 11 expression expression NN cord-251986-ajlpb9li 88 12 profiling profiling NN cord-251986-ajlpb9li 88 13 of of IN cord-251986-ajlpb9li 88 14 ACE ace NN cord-251986-ajlpb9li 88 15 2 2 CD cord-251986-ajlpb9li 88 16 , , , cord-251986-ajlpb9li 88 17 a a DT cord-251986-ajlpb9li 88 18 novel novel JJ cord-251986-ajlpb9li 88 19 homologue homologue NN cord-251986-ajlpb9li 88 20 of of IN cord-251986-ajlpb9li 88 21 angiotensin angiotensin NN cord-251986-ajlpb9li 88 22 converting convert VBG cord-251986-ajlpb9li 88 23 enzyme enzyme NN cord-251986-ajlpb9li 88 24 Tissue tissue NN cord-251986-ajlpb9li 88 25 distribution distribution NN cord-251986-ajlpb9li 88 26 of of IN cord-251986-ajlpb9li 88 27 ACE2 ACE2 NNP cord-251986-ajlpb9li 88 28 protein protein NN cord-251986-ajlpb9li 88 29 , , , cord-251986-ajlpb9li 88 30 the the DT cord-251986-ajlpb9li 88 31 functional functional JJ cord-251986-ajlpb9li 88 32 receptor receptor NN cord-251986-ajlpb9li 88 33 for for IN cord-251986-ajlpb9li 88 34 SARS SARS NNP cord-251986-ajlpb9li 88 35 coronavirus coronavirus NN cord-251986-ajlpb9li 88 36 . . . cord-251986-ajlpb9li 89 1 A a DT cord-251986-ajlpb9li 89 2 first first JJ cord-251986-ajlpb9li 89 3 step step NN cord-251986-ajlpb9li 89 4 in in IN cord-251986-ajlpb9li 89 5 understanding understand VBG cord-251986-ajlpb9li 89 6 SARS SARS NNP cord-251986-ajlpb9li 89 7 pathogenesis pathogenesis NN cord-251986-ajlpb9li 89 8 Expression expression NN cord-251986-ajlpb9li 89 9 of of IN cord-251986-ajlpb9li 89 10 CD26 CD26 NNP cord-251986-ajlpb9li 89 11 ( ( -LRB- cord-251986-ajlpb9li 89 12 dipeptidyl dipeptidyl JJ cord-251986-ajlpb9li 89 13 peptidase peptidase NN cord-251986-ajlpb9li 89 14 IV IV NNP cord-251986-ajlpb9li 89 15 ) ) -RRB- cord-251986-ajlpb9li 89 16 on on IN cord-251986-ajlpb9li 89 17 resting rest VBG cord-251986-ajlpb9li 89 18 and and CC cord-251986-ajlpb9li 89 19 activated activate VBN cord-251986-ajlpb9li 89 20 human human JJ cord-251986-ajlpb9li 89 21 T t NN cord-251986-ajlpb9li 89 22 - - HYPH cord-251986-ajlpb9li 89 23 lymphocytes lymphocyte NNS cord-251986-ajlpb9li 90 1 The the DT cord-251986-ajlpb9li 90 2 multifunctional multifunctional JJ cord-251986-ajlpb9li 90 3 or or CC cord-251986-ajlpb9li 90 4 moonlighting moonlight VBG cord-251986-ajlpb9li 90 5 protein protein NN cord-251986-ajlpb9li 91 1 CD26 CD26 NNP cord-251986-ajlpb9li 91 2 / / SYM cord-251986-ajlpb9li 91 3 DPPIV DPPIV NNP cord-251986-ajlpb9li 91 4 Persistent persistent JJ cord-251986-ajlpb9li 91 5 infection infection NN cord-251986-ajlpb9li 91 6 of of IN cord-251986-ajlpb9li 91 7 SARS SARS NNP cord-251986-ajlpb9li 91 8 coronavirus coronavirus NN cord-251986-ajlpb9li 91 9 in in IN cord-251986-ajlpb9li 91 10 colonic colonic JJ cord-251986-ajlpb9li 91 11 cells cell NNS cord-251986-ajlpb9li 91 12 in in IN cord-251986-ajlpb9li 91 13 vitro vitro FW cord-251986-ajlpb9li 92 1 The the DT cord-251986-ajlpb9li 92 2 clinical clinical JJ cord-251986-ajlpb9li 92 3 pathology pathology NN cord-251986-ajlpb9li 92 4 of of IN cord-251986-ajlpb9li 92 5 severe severe JJ cord-251986-ajlpb9li 92 6 acute acute JJ cord-251986-ajlpb9li 92 7 respiratory respiratory JJ cord-251986-ajlpb9li 92 8 syndrome syndrome NN cord-251986-ajlpb9li 92 9 ( ( -LRB- cord-251986-ajlpb9li 92 10 SARS SARS NNP cord-251986-ajlpb9li 92 11 ) ) -RRB- cord-251986-ajlpb9li 92 12 : : : cord-251986-ajlpb9li 93 1 a a DT cord-251986-ajlpb9li 93 2 report report NN cord-251986-ajlpb9li 93 3 from from IN cord-251986-ajlpb9li 93 4 Dipeptidyl Dipeptidyl NNP cord-251986-ajlpb9li 93 5 peptidase peptidase NN cord-251986-ajlpb9li 93 6 IV IV NNP cord-251986-ajlpb9li 93 7 , , , cord-251986-ajlpb9li 93 8 which which WDT cord-251986-ajlpb9li 93 9 probably probably RB cord-251986-ajlpb9li 93 10 plays play VBZ cord-251986-ajlpb9li 93 11 important important JJ cord-251986-ajlpb9li 93 12 roles role NNS cord-251986-ajlpb9li 93 13 in in IN cord-251986-ajlpb9li 93 14 alzheimer alzheimer NNP cord-251986-ajlpb9li 93 15 disease disease NNP cord-251986-ajlpb9li 93 16 ( ( -LRB- cord-251986-ajlpb9li 93 17 AD ad NN cord-251986-ajlpb9li 93 18 ) ) -RRB- cord-251986-ajlpb9li 93 19 pathology pathology NN cord-251986-ajlpb9li 93 20 , , , cord-251986-ajlpb9li 93 21 is be VBZ cord-251986-ajlpb9li 93 22 upregulated upregulate VBN cord-251986-ajlpb9li 93 23 in in IN cord-251986-ajlpb9li 93 24 AD ad NN cord-251986-ajlpb9li 93 25 brain brain NN cord-251986-ajlpb9li 93 26 neurons neuron NNS cord-251986-ajlpb9li 93 27 and and CC cord-251986-ajlpb9li 93 28 associates associate NNS cord-251986-ajlpb9li 93 29 with with IN cord-251986-ajlpb9li 93 30 amyloid amyloid NN cord-251986-ajlpb9li 93 31 plaques plaque NNS cord-251986-ajlpb9li 93 32 Organ Organ NNP cord-251986-ajlpb9li 93 33 distribution distribution NN cord-251986-ajlpb9li 93 34 of of IN cord-251986-ajlpb9li 93 35 severe severe JJ cord-251986-ajlpb9li 93 36 acute acute JJ cord-251986-ajlpb9li 93 37 respiratory respiratory JJ cord-251986-ajlpb9li 93 38 syndrome syndrome NN cord-251986-ajlpb9li 93 39 ( ( -LRB- cord-251986-ajlpb9li 93 40 SARS SARS NNP cord-251986-ajlpb9li 93 41 ) ) -RRB- cord-251986-ajlpb9li 93 42 associated associate VBD cord-251986-ajlpb9li 93 43 coronavirus coronavirus NN cord-251986-ajlpb9li 93 44 ( ( -LRB- cord-251986-ajlpb9li 93 45 SARS SARS NNP cord-251986-ajlpb9li 93 46 - - HYPH cord-251986-ajlpb9li 93 47 CoV CoV NNP cord-251986-ajlpb9li 93 48 ) ) -RRB- cord-251986-ajlpb9li 93 49 in in IN cord-251986-ajlpb9li 93 50 SARS SARS NNP cord-251986-ajlpb9li 93 51 patients patient NNS cord-251986-ajlpb9li 93 52 : : : cord-251986-ajlpb9li 93 53 implications implication NNS cord-251986-ajlpb9li 93 54 for for IN cord-251986-ajlpb9li 93 55 pathogenesis pathogenesis NN cord-251986-ajlpb9li 93 56 and and CC cord-251986-ajlpb9li 93 57 virus virus NN cord-251986-ajlpb9li 93 58 transmission transmission NN cord-251986-ajlpb9li 93 59 pathways pathway NNS cord-251986-ajlpb9li 94 1 Multiple multiple JJ cord-251986-ajlpb9li 94 2 organ organ NN cord-251986-ajlpb9li 94 3 infection infection NN cord-251986-ajlpb9li 94 4 and and CC cord-251986-ajlpb9li 94 5 the the DT cord-251986-ajlpb9li 94 6 pathogenesis pathogenesis NN cord-251986-ajlpb9li 94 7 of of IN cord-251986-ajlpb9li 94 8 SARS SARS NNP cord-251986-ajlpb9li 94 9 Detection Detection NNP cord-251986-ajlpb9li 94 10 of of IN cord-251986-ajlpb9li 94 11 severe severe JJ cord-251986-ajlpb9li 94 12 acute acute JJ cord-251986-ajlpb9li 94 13 respiratory respiratory JJ cord-251986-ajlpb9li 94 14 syndrome syndrome NN cord-251986-ajlpb9li 94 15 coronavirus coronavirus NN cord-251986-ajlpb9li 94 16 in in IN cord-251986-ajlpb9li 94 17 the the DT cord-251986-ajlpb9li 94 18 brain brain NN cord-251986-ajlpb9li 94 19 : : : cord-251986-ajlpb9li 94 20 potential potential JJ cord-251986-ajlpb9li 94 21 role role NN cord-251986-ajlpb9li 94 22 of of IN cord-251986-ajlpb9li 94 23 the the DT cord-251986-ajlpb9li 94 24 chemokine chemokine NN cord-251986-ajlpb9li 94 25 mig mig NNP cord-251986-ajlpb9li 94 26 in in IN cord-251986-ajlpb9li 94 27 pathogenesis pathogenesis NN cord-251986-ajlpb9li 94 28 Severe severe JJ cord-251986-ajlpb9li 94 29 acute acute JJ cord-251986-ajlpb9li 94 30 respiratory respiratory JJ cord-251986-ajlpb9li 94 31 syndrome syndrome NN cord-251986-ajlpb9li 94 32 coronavirus coronavirus NN cord-251986-ajlpb9li 94 33 infection infection NN cord-251986-ajlpb9li 94 34 causes cause VBZ cord-251986-ajlpb9li 94 35 neuronal neuronal JJ cord-251986-ajlpb9li 94 36 death death NN cord-251986-ajlpb9li 94 37 in in IN cord-251986-ajlpb9li 94 38 the the DT cord-251986-ajlpb9li 94 39 absence absence NN cord-251986-ajlpb9li 94 40 of of IN cord-251986-ajlpb9li 94 41 encephalitis encephalitis NN cord-251986-ajlpb9li 94 42 in in IN cord-251986-ajlpb9li 94 43 mice mouse NNS cord-251986-ajlpb9li 94 44 transgenic transgenic JJ cord-251986-ajlpb9li 94 45 for for IN cord-251986-ajlpb9li 94 46 human human JJ cord-251986-ajlpb9li 94 47 ACE2 ACE2 NNP cord-251986-ajlpb9li 94 48 Lethal lethal JJ cord-251986-ajlpb9li 94 49 infection infection NN cord-251986-ajlpb9li 94 50 of of IN cord-251986-ajlpb9li 94 51 K18-hACE2 k18-hace2 JJ cord-251986-ajlpb9li 94 52 mice mouse NNS cord-251986-ajlpb9li 94 53 infected infect VBN cord-251986-ajlpb9li 94 54 with with IN cord-251986-ajlpb9li 94 55 severe severe JJ cord-251986-ajlpb9li 94 56 acute acute JJ cord-251986-ajlpb9li 94 57 respiratory respiratory JJ cord-251986-ajlpb9li 94 58 syndrome syndrome NN cord-251986-ajlpb9li 94 59 coronavirus coronavirus NN cord-251986-ajlpb9li 95 1 The the DT cord-251986-ajlpb9li 95 2 vagus vagus NN cord-251986-ajlpb9li 95 3 nerve nerve NN cord-251986-ajlpb9li 95 4 is be VBZ cord-251986-ajlpb9li 95 5 one one CD cord-251986-ajlpb9li 95 6 route route NN cord-251986-ajlpb9li 95 7 of of IN cord-251986-ajlpb9li 95 8 transneural transneural JJ cord-251986-ajlpb9li 95 9 invasion invasion NN cord-251986-ajlpb9li 95 10 for for IN cord-251986-ajlpb9li 95 11 intranasally intranasally RB cord-251986-ajlpb9li 95 12 inoculated inoculate VBN cord-251986-ajlpb9li 95 13 influenza influenza NN cord-251986-ajlpb9li 95 14 a a DT cord-251986-ajlpb9li 95 15 virus virus NN cord-251986-ajlpb9li 95 16 in in IN cord-251986-ajlpb9li 95 17 mice mouse NNS cord-251986-ajlpb9li 96 1 Morphogenesis morphogenesis NN cord-251986-ajlpb9li 96 2 of of IN cord-251986-ajlpb9li 96 3 avian avian JJ cord-251986-ajlpb9li 96 4 infectious infectious JJ cord-251986-ajlpb9li 96 5 bronchitis bronchitis NN cord-251986-ajlpb9li 96 6 virus virus NN cord-251986-ajlpb9li 96 7 in in IN cord-251986-ajlpb9li 96 8 primary primary JJ cord-251986-ajlpb9li 96 9 chick chick NN cord-251986-ajlpb9li 96 10 kidney kidney NN cord-251986-ajlpb9li 96 11 cells cell NNS cord-251986-ajlpb9li 97 1 A a DT cord-251986-ajlpb9li 97 2 comparative comparative JJ cord-251986-ajlpb9li 97 3 sequence sequence NN cord-251986-ajlpb9li 97 4 analysis analysis NN cord-251986-ajlpb9li 97 5 to to TO cord-251986-ajlpb9li 97 6 revise revise VB cord-251986-ajlpb9li 97 7 the the DT cord-251986-ajlpb9li 97 8 current current JJ cord-251986-ajlpb9li 97 9 taxonomy taxonomy NN cord-251986-ajlpb9li 97 10 of of IN cord-251986-ajlpb9li 97 11 the the DT cord-251986-ajlpb9li 97 12 family family NN cord-251986-ajlpb9li 97 13 coronaviridae coronaviridae NNP cord-251986-ajlpb9li 98 1 The the DT cord-251986-ajlpb9li 98 2 evidence evidence NN cord-251986-ajlpb9li 98 3 of of IN cord-251986-ajlpb9li 98 4 porcine porcine JJ cord-251986-ajlpb9li 98 5 hemagglutinating hemagglutinate VBG cord-251986-ajlpb9li 98 6 encephalomyelitis encephalomyelitis NN cord-251986-ajlpb9li 98 7 virus virus NN cord-251986-ajlpb9li 98 8 induced induce VBD cord-251986-ajlpb9li 98 9 nonsuppurative nonsuppurative RB cord-251986-ajlpb9li 98 10 encephalitis encephalitis RB cord-251986-ajlpb9li 98 11 as as IN cord-251986-ajlpb9li 98 12 the the DT cord-251986-ajlpb9li 98 13 cause cause NN cord-251986-ajlpb9li 98 14 of of IN cord-251986-ajlpb9li 98 15 death death NN cord-251986-ajlpb9li 98 16 in in IN cord-251986-ajlpb9li 98 17 piglets piglet NNS cord-251986-ajlpb9li 98 18 Brain Brain NNP cord-251986-ajlpb9li 98 19 stem stem NN cord-251986-ajlpb9li 98 20 projections projection NNS cord-251986-ajlpb9li 98 21 of of IN cord-251986-ajlpb9li 98 22 sensory sensory JJ cord-251986-ajlpb9li 98 23 and and CC cord-251986-ajlpb9li 98 24 motor motor NN cord-251986-ajlpb9li 98 25 components component NNS cord-251986-ajlpb9li 98 26 of of IN cord-251986-ajlpb9li 98 27 the the DT cord-251986-ajlpb9li 98 28 vagus vagus NN cord-251986-ajlpb9li 98 29 complex complex NN cord-251986-ajlpb9li 98 30 in in IN cord-251986-ajlpb9li 98 31 the the DT cord-251986-ajlpb9li 98 32 cat cat NN cord-251986-ajlpb9li 98 33 : : : cord-251986-ajlpb9li 98 34 II II NNP cord-251986-ajlpb9li 98 35 . . . cord-251986-ajlpb9li 99 1 Laryngeal Laryngeal NNP cord-251986-ajlpb9li 99 2 , , , cord-251986-ajlpb9li 99 3 tracheobronchial tracheobronchial JJ cord-251986-ajlpb9li 99 4 , , , cord-251986-ajlpb9li 99 5 pulmonary pulmonary JJ cord-251986-ajlpb9li 99 6 , , , cord-251986-ajlpb9li 99 7 cardiac cardiac JJ cord-251986-ajlpb9li 99 8 , , , cord-251986-ajlpb9li 99 9 and and CC cord-251986-ajlpb9li 99 10 gastrointestinal gastrointestinal JJ cord-251986-ajlpb9li 99 11 branches branch NNS cord-251986-ajlpb9li 99 12 CNS cns JJ cord-251986-ajlpb9li 99 13 innervation innervation NN cord-251986-ajlpb9li 99 14 of of IN cord-251986-ajlpb9li 99 15 vagal vagal JJ cord-251986-ajlpb9li 99 16 preganglionic preganglionic JJ cord-251986-ajlpb9li 99 17 neurons neuron NNS cord-251986-ajlpb9li 99 18 controlling control VBG cord-251986-ajlpb9li 99 19 peripheral peripheral NNP cord-251986-ajlpb9li 99 20 airways airways NNPS cord-251986-ajlpb9li 99 21 : : : cord-251986-ajlpb9li 99 22 a a DT cord-251986-ajlpb9li 99 23 transneuronal transneuronal JJ cord-251986-ajlpb9li 99 24 labeling labeling NN cord-251986-ajlpb9li 99 25 study study NN cord-251986-ajlpb9li 99 26 using use VBG cord-251986-ajlpb9li 99 27 pseudorabies pseudorabies NN cord-251986-ajlpb9li 99 28 virus virus NN cord-251986-ajlpb9li 99 29 Interaction Interaction NNP cord-251986-ajlpb9li 99 30 of of IN cord-251986-ajlpb9li 99 31 the the DT cord-251986-ajlpb9li 99 32 rabies rabies NN cord-251986-ajlpb9li 99 33 virus virus NN cord-251986-ajlpb9li 99 34 P p NN cord-251986-ajlpb9li 99 35 protein protein NN cord-251986-ajlpb9li 99 36 with with IN cord-251986-ajlpb9li 99 37 the the DT cord-251986-ajlpb9li 99 38 LC8 lc8 JJ cord-251986-ajlpb9li 99 39 dynein dynein NNP cord-251986-ajlpb9li 99 40 light light NN cord-251986-ajlpb9li 99 41 chain chain NN cord-251986-ajlpb9li 99 42 Neurological Neurological NNP cord-251986-ajlpb9li 99 43 Manifestations manifestation NNS cord-251986-ajlpb9li 99 44 of of IN cord-251986-ajlpb9li 99 45 Hospitalized Hospitalized NNP cord-251986-ajlpb9li 99 46 Patients Patients NNPS cord-251986-ajlpb9li 99 47 with with IN cord-251986-ajlpb9li 99 48 COVID-19 COVID-19 NNP cord-251986-ajlpb9li 99 49 in in IN cord-251986-ajlpb9li 99 50 Wuhan Wuhan NNP cord-251986-ajlpb9li 99 51 , , , cord-251986-ajlpb9li 99 52 China China NNP cord-251986-ajlpb9li 99 53 : : : cord-251986-ajlpb9li 100 1 a a DT cord-251986-ajlpb9li 100 2 retrospective retrospective JJ cord-251986-ajlpb9li 100 3 case case NN cord-251986-ajlpb9li 100 4 series series NN cord-251986-ajlpb9li 100 5 study study NN cord-251986-ajlpb9li 101 1 The the DT cord-251986-ajlpb9li 101 2 neuroinvasive neuroinvasive JJ cord-251986-ajlpb9li 101 3 potential potential NN cord-251986-ajlpb9li 101 4 of of IN cord-251986-ajlpb9li 101 5 SARS SARS NNP cord-251986-ajlpb9li 101 6 - - HYPH cord-251986-ajlpb9li 101 7 CoV2 CoV2 NNP cord-251986-ajlpb9li 101 8 may may MD cord-251986-ajlpb9li 101 9 play play VB cord-251986-ajlpb9li 101 10 a a DT cord-251986-ajlpb9li 101 11 role role NN cord-251986-ajlpb9li 101 12 in in IN cord-251986-ajlpb9li 101 13 the the DT cord-251986-ajlpb9li 101 14 respiratory respiratory JJ cord-251986-ajlpb9li 101 15 failure failure NN cord-251986-ajlpb9li 101 16 of of IN cord-251986-ajlpb9li 101 17 COVID-19 covid-19 JJ cord-251986-ajlpb9li 101 18 patients patient NNS