id sid tid token lemma pos cord-345211-4ivqlsgt 1 1 key key NN cord-345211-4ivqlsgt 1 2 : : : cord-345211-4ivqlsgt 2 1 cord-345211 cord-345211 NNP cord-345211-4ivqlsgt 2 2 - - : cord-345211-4ivqlsgt 2 3 4ivqlsgt 4ivqlsgt CD cord-345211-4ivqlsgt 2 4 authors author NNS cord-345211-4ivqlsgt 2 5 : : : cord-345211-4ivqlsgt 2 6 Murdoch Murdoch NNP cord-345211-4ivqlsgt 2 7 , , , cord-345211-4ivqlsgt 2 8 David David NNP cord-345211-4ivqlsgt 2 9 R. R. NNP cord-345211-4ivqlsgt 2 10 title title NN cord-345211-4ivqlsgt 2 11 : : : cord-345211-4ivqlsgt 2 12 How how WRB cord-345211-4ivqlsgt 2 13 recent recent JJ cord-345211-4ivqlsgt 2 14 advances advance NNS cord-345211-4ivqlsgt 2 15 in in IN cord-345211-4ivqlsgt 2 16 molecular molecular JJ cord-345211-4ivqlsgt 2 17 tests test NNS cord-345211-4ivqlsgt 2 18 could could MD cord-345211-4ivqlsgt 2 19 impact impact VB cord-345211-4ivqlsgt 2 20 the the DT cord-345211-4ivqlsgt 2 21 diagnosis diagnosis NN cord-345211-4ivqlsgt 2 22 of of IN cord-345211-4ivqlsgt 2 23 pneumonia pneumonia NN cord-345211-4ivqlsgt 2 24 date date NN cord-345211-4ivqlsgt 2 25 : : : cord-345211-4ivqlsgt 2 26 2016 2016 CD cord-345211-4ivqlsgt 2 27 - - HYPH cord-345211-4ivqlsgt 2 28 03 03 CD cord-345211-4ivqlsgt 2 29 - - HYPH cord-345211-4ivqlsgt 2 30 07 07 CD cord-345211-4ivqlsgt 2 31 journal journal NN cord-345211-4ivqlsgt 2 32 : : : cord-345211-4ivqlsgt 3 1 Expert Expert NNP cord-345211-4ivqlsgt 3 2 Rev Rev NNP cord-345211-4ivqlsgt 3 3 Mol Mol NNP cord-345211-4ivqlsgt 3 4 Diagn Diagn NNP cord-345211-4ivqlsgt 3 5 DOI doi NN cord-345211-4ivqlsgt 3 6 : : : cord-345211-4ivqlsgt 4 1 10.1586/14737159.2016.1156536 10.1586/14737159.2016.1156536 NNP cord-345211-4ivqlsgt 4 2 sha sha NNP cord-345211-4ivqlsgt 4 3 : : : cord-345211-4ivqlsgt 5 1 9775b80a0f13a6b29c78338b26f40316bec7b71f 9775b80a0f13a6b29c78338b26f40316bec7b71f NNP cord-345211-4ivqlsgt 5 2 doc_id doc_id CD cord-345211-4ivqlsgt 6 1 : : : cord-345211-4ivqlsgt 6 2 345211 345211 CD cord-345211-4ivqlsgt 6 3 cord_uid cord_uid NN cord-345211-4ivqlsgt 6 4 : : : cord-345211-4ivqlsgt 7 1 4ivqlsgt 4ivqlsgt LS cord-345211-4ivqlsgt 7 2 Molecular molecular JJ cord-345211-4ivqlsgt 7 3 diagnostic diagnostic JJ cord-345211-4ivqlsgt 7 4 tests test NNS cord-345211-4ivqlsgt 7 5 have have VBP cord-345211-4ivqlsgt 7 6 been be VBN cord-345211-4ivqlsgt 7 7 the the DT cord-345211-4ivqlsgt 7 8 single single JJ cord-345211-4ivqlsgt 7 9 major major JJ cord-345211-4ivqlsgt 7 10 development development NN cord-345211-4ivqlsgt 7 11 in in IN cord-345211-4ivqlsgt 7 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 7 13 diagnostics diagnostic NNS cord-345211-4ivqlsgt 7 14 over over IN cord-345211-4ivqlsgt 7 15 recent recent JJ cord-345211-4ivqlsgt 7 16 years year NNS cord-345211-4ivqlsgt 7 17 . . . cord-345211-4ivqlsgt 8 1 Nucleic nucleic JJ cord-345211-4ivqlsgt 8 2 acid acid NN cord-345211-4ivqlsgt 8 3 detection detection NN cord-345211-4ivqlsgt 8 4 tests test NNS cord-345211-4ivqlsgt 8 5 ( ( -LRB- cord-345211-4ivqlsgt 8 6 NATs NATs NNP cord-345211-4ivqlsgt 8 7 ) ) -RRB- cord-345211-4ivqlsgt 8 8 have have VBP cord-345211-4ivqlsgt 8 9 greatly greatly RB cord-345211-4ivqlsgt 8 10 improved improve VBN cord-345211-4ivqlsgt 8 11 the the DT cord-345211-4ivqlsgt 8 12 ability ability NN cord-345211-4ivqlsgt 8 13 to to TO cord-345211-4ivqlsgt 8 14 detect detect VB cord-345211-4ivqlsgt 8 15 respiratory respiratory JJ cord-345211-4ivqlsgt 8 16 viruses virus NNS cord-345211-4ivqlsgt 8 17 and and CC cord-345211-4ivqlsgt 8 18 bacterial bacterial JJ cord-345211-4ivqlsgt 8 19 pathogens pathogen NNS cord-345211-4ivqlsgt 8 20 that that WDT cord-345211-4ivqlsgt 8 21 do do VBP cord-345211-4ivqlsgt 8 22 not not RB cord-345211-4ivqlsgt 8 23 normally normally RB cord-345211-4ivqlsgt 8 24 colonize colonize VB cord-345211-4ivqlsgt 8 25 the the DT cord-345211-4ivqlsgt 8 26 respiratory respiratory JJ cord-345211-4ivqlsgt 8 27 tract tract NN cord-345211-4ivqlsgt 8 28 . . . cord-345211-4ivqlsgt 9 1 In in IN cord-345211-4ivqlsgt 9 2 contrast contrast NN cord-345211-4ivqlsgt 9 3 , , , cord-345211-4ivqlsgt 9 4 NATs NATs NNP cord-345211-4ivqlsgt 9 5 do do VBP cord-345211-4ivqlsgt 9 6 not not RB cord-345211-4ivqlsgt 9 7 yet yet RB cord-345211-4ivqlsgt 9 8 have have VB cord-345211-4ivqlsgt 9 9 an an DT cord-345211-4ivqlsgt 9 10 established establish VBN cord-345211-4ivqlsgt 9 11 role role NN cord-345211-4ivqlsgt 9 12 for for IN cord-345211-4ivqlsgt 9 13 diagnosing diagnose VBG cord-345211-4ivqlsgt 9 14 pneumonia pneumonia NN cord-345211-4ivqlsgt 9 15 caused cause VBN cord-345211-4ivqlsgt 9 16 by by IN cord-345211-4ivqlsgt 9 17 bacteria bacteria NNS cord-345211-4ivqlsgt 9 18 that that WDT cord-345211-4ivqlsgt 9 19 commonly commonly RB cord-345211-4ivqlsgt 9 20 colonize colonize VBP cord-345211-4ivqlsgt 9 21 the the DT cord-345211-4ivqlsgt 9 22 nasopharynx nasopharynx NN cord-345211-4ivqlsgt 9 23 due due JJ cord-345211-4ivqlsgt 9 24 to to IN cord-345211-4ivqlsgt 9 25 difficulties difficulty NNS cord-345211-4ivqlsgt 9 26 discriminating discriminate VBG cord-345211-4ivqlsgt 9 27 between between IN cord-345211-4ivqlsgt 9 28 pathogens pathogen NNS cord-345211-4ivqlsgt 9 29 and and CC cord-345211-4ivqlsgt 9 30 coincidental coincidental JJ cord-345211-4ivqlsgt 9 31 carriage carriage NN cord-345211-4ivqlsgt 9 32 strains strain NNS cord-345211-4ivqlsgt 9 33 . . . cord-345211-4ivqlsgt 10 1 New new JJ cord-345211-4ivqlsgt 10 2 approaches approach NNS cord-345211-4ivqlsgt 10 3 are be VBP cord-345211-4ivqlsgt 10 4 needed need VBN cord-345211-4ivqlsgt 10 5 to to TO cord-345211-4ivqlsgt 10 6 distinguish distinguish VB cord-345211-4ivqlsgt 10 7 infection infection NN cord-345211-4ivqlsgt 10 8 from from IN cord-345211-4ivqlsgt 10 9 colonization colonization NN cord-345211-4ivqlsgt 10 10 , , , cord-345211-4ivqlsgt 10 11 such such JJ cord-345211-4ivqlsgt 10 12 as as IN cord-345211-4ivqlsgt 10 13 through through IN cord-345211-4ivqlsgt 10 14 use use NN cord-345211-4ivqlsgt 10 15 of of IN cord-345211-4ivqlsgt 10 16 quantitative quantitative JJ cord-345211-4ivqlsgt 10 17 methods method NNS cord-345211-4ivqlsgt 10 18 and and CC cord-345211-4ivqlsgt 10 19 identification identification NN cord-345211-4ivqlsgt 10 20 of of IN cord-345211-4ivqlsgt 10 21 discriminating discriminate VBG cord-345211-4ivqlsgt 10 22 cut cut VB cord-345211-4ivqlsgt 10 23 - - HYPH cord-345211-4ivqlsgt 10 24 off off RP cord-345211-4ivqlsgt 10 25 levels level NNS cord-345211-4ivqlsgt 10 26 . . . cord-345211-4ivqlsgt 11 1 The the DT cord-345211-4ivqlsgt 11 2 recent recent JJ cord-345211-4ivqlsgt 11 3 realization realization NN cord-345211-4ivqlsgt 11 4 that that IN cord-345211-4ivqlsgt 11 5 the the DT cord-345211-4ivqlsgt 11 6 lung lung NN cord-345211-4ivqlsgt 11 7 microbiome microbiome NN cord-345211-4ivqlsgt 11 8 exists exist VBZ cord-345211-4ivqlsgt 11 9 has have VBZ cord-345211-4ivqlsgt 11 10 provided provide VBN cord-345211-4ivqlsgt 11 11 new new JJ cord-345211-4ivqlsgt 11 12 insights insight NNS cord-345211-4ivqlsgt 11 13 into into IN cord-345211-4ivqlsgt 11 14 the the DT cord-345211-4ivqlsgt 11 15 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 11 16 of of IN cord-345211-4ivqlsgt 11 17 pneumonia pneumonia NN cord-345211-4ivqlsgt 11 18 involving involve VBG cord-345211-4ivqlsgt 11 19 the the DT cord-345211-4ivqlsgt 11 20 interaction interaction NN cord-345211-4ivqlsgt 11 21 between between IN cord-345211-4ivqlsgt 11 22 multiple multiple JJ cord-345211-4ivqlsgt 11 23 microorganisms microorganism NNS cord-345211-4ivqlsgt 11 24 . . . cord-345211-4ivqlsgt 12 1 New new JJ cord-345211-4ivqlsgt 12 2 developments development NNS cord-345211-4ivqlsgt 12 3 in in IN cord-345211-4ivqlsgt 12 4 molecular molecular JJ cord-345211-4ivqlsgt 12 5 diagnostics diagnostic NNS cord-345211-4ivqlsgt 12 6 must must MD cord-345211-4ivqlsgt 12 7 account account VB cord-345211-4ivqlsgt 12 8 for for IN cord-345211-4ivqlsgt 12 9 this this DT cord-345211-4ivqlsgt 12 10 new new JJ cord-345211-4ivqlsgt 12 11 paradigm paradigm NN cord-345211-4ivqlsgt 12 12 . . . cord-345211-4ivqlsgt 13 1 Pneumonia pneumonia NN cord-345211-4ivqlsgt 13 2 continues continue VBZ cord-345211-4ivqlsgt 13 3 to to TO cord-345211-4ivqlsgt 13 4 provide provide VB cord-345211-4ivqlsgt 13 5 a a DT cord-345211-4ivqlsgt 13 6 huge huge JJ cord-345211-4ivqlsgt 13 7 global global JJ cord-345211-4ivqlsgt 13 8 burden burden NN cord-345211-4ivqlsgt 13 9 of of IN cord-345211-4ivqlsgt 13 10 disease disease NN cord-345211-4ivqlsgt 13 11 [ [ -LRB- cord-345211-4ivqlsgt 13 12 1 1 CD cord-345211-4ivqlsgt 13 13 ] ] -RRB- cord-345211-4ivqlsgt 13 14 . . . cord-345211-4ivqlsgt 14 1 Although although IN cord-345211-4ivqlsgt 14 2 the the DT cord-345211-4ivqlsgt 14 3 incidence incidence NN cord-345211-4ivqlsgt 14 4 of of IN cord-345211-4ivqlsgt 14 5 pneumonia pneumonia NN cord-345211-4ivqlsgt 14 6 increases increase VBZ cord-345211-4ivqlsgt 14 7 with with IN cord-345211-4ivqlsgt 14 8 increasing increase VBG cord-345211-4ivqlsgt 14 9 age age NN cord-345211-4ivqlsgt 14 10 , , , cord-345211-4ivqlsgt 14 11 it -PRON- PRP cord-345211-4ivqlsgt 14 12 is be VBZ cord-345211-4ivqlsgt 14 13 not not RB cord-345211-4ivqlsgt 14 14 widely widely RB cord-345211-4ivqlsgt 14 15 appreciated appreciate VBN cord-345211-4ivqlsgt 14 16 that that IN cord-345211-4ivqlsgt 14 17 pneumonia pneumonia NN cord-345211-4ivqlsgt 14 18 is be VBZ cord-345211-4ivqlsgt 14 19 also also RB cord-345211-4ivqlsgt 14 20 the the DT cord-345211-4ivqlsgt 14 21 world world NN cord-345211-4ivqlsgt 14 22 's 's POS cord-345211-4ivqlsgt 14 23 biggest big JJS cord-345211-4ivqlsgt 14 24 killer killer NN cord-345211-4ivqlsgt 14 25 of of IN cord-345211-4ivqlsgt 14 26 young young JJ cord-345211-4ivqlsgt 14 27 children child NNS cord-345211-4ivqlsgt 14 28 [ [ -LRB- cord-345211-4ivqlsgt 14 29 2 2 CD cord-345211-4ivqlsgt 14 30 ] ] -RRB- cord-345211-4ivqlsgt 14 31 . . . cord-345211-4ivqlsgt 15 1 A a DT cord-345211-4ivqlsgt 15 2 wide wide JJ cord-345211-4ivqlsgt 15 3 variety variety NN cord-345211-4ivqlsgt 15 4 of of IN cord-345211-4ivqlsgt 15 5 microorganisms microorganism NNS cord-345211-4ivqlsgt 15 6 are be VBP cord-345211-4ivqlsgt 15 7 listed list VBN cord-345211-4ivqlsgt 15 8 as as IN cord-345211-4ivqlsgt 15 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 15 10 pathogens pathogen NNS cord-345211-4ivqlsgt 15 11 [ [ -LRB- cord-345211-4ivqlsgt 15 12 3 3 CD cord-345211-4ivqlsgt 15 13 ] ] -RRB- cord-345211-4ivqlsgt 15 14 , , , cord-345211-4ivqlsgt 15 15 and and CC cord-345211-4ivqlsgt 15 16 identification identification NN cord-345211-4ivqlsgt 15 17 of of IN cord-345211-4ivqlsgt 15 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 15 19 etiology etiology NN cord-345211-4ivqlsgt 15 20 is be VBZ cord-345211-4ivqlsgt 15 21 useful useful JJ cord-345211-4ivqlsgt 15 22 for for IN cord-345211-4ivqlsgt 15 23 both both DT cord-345211-4ivqlsgt 15 24 patient patient JJ cord-345211-4ivqlsgt 15 25 management management NN cord-345211-4ivqlsgt 15 26 and and CC cord-345211-4ivqlsgt 15 27 surveillance surveillance NN cord-345211-4ivqlsgt 15 28 purposes purpose NNS cord-345211-4ivqlsgt 15 29 . . . cord-345211-4ivqlsgt 16 1 However however RB cord-345211-4ivqlsgt 16 2 , , , cord-345211-4ivqlsgt 16 3 despite despite IN cord-345211-4ivqlsgt 16 4 increased increase VBN cord-345211-4ivqlsgt 16 5 recognition recognition NN cord-345211-4ivqlsgt 16 6 of of IN cord-345211-4ivqlsgt 16 7 the the DT cord-345211-4ivqlsgt 16 8 burden burden NN cord-345211-4ivqlsgt 16 9 of of IN cord-345211-4ivqlsgt 16 10 disease disease NN cord-345211-4ivqlsgt 16 11 and and CC cord-345211-4ivqlsgt 16 12 advances advance NNS cord-345211-4ivqlsgt 16 13 in in IN cord-345211-4ivqlsgt 16 14 effective effective JJ cord-345211-4ivqlsgt 16 15 vaccines vaccine NNS cord-345211-4ivqlsgt 16 16 against against IN cord-345211-4ivqlsgt 16 17 major major JJ cord-345211-4ivqlsgt 16 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 16 19 pathogens pathogen NNS cord-345211-4ivqlsgt 16 20 , , , cord-345211-4ivqlsgt 16 21 we -PRON- PRP cord-345211-4ivqlsgt 16 22 continue continue VBP cord-345211-4ivqlsgt 16 23 to to TO cord-345211-4ivqlsgt 16 24 struggle struggle VB cord-345211-4ivqlsgt 16 25 in in IN cord-345211-4ivqlsgt 16 26 our -PRON- PRP$ cord-345211-4ivqlsgt 16 27 efforts effort NNS cord-345211-4ivqlsgt 16 28 to to TO cord-345211-4ivqlsgt 16 29 identify identify VB cord-345211-4ivqlsgt 16 30 the the DT cord-345211-4ivqlsgt 16 31 pathogens pathogen NNS cord-345211-4ivqlsgt 16 32 that that WDT cord-345211-4ivqlsgt 16 33 cause cause VBP cord-345211-4ivqlsgt 16 34 pneumonia pneumonia NN cord-345211-4ivqlsgt 16 35 in in IN cord-345211-4ivqlsgt 16 36 individual individual JJ cord-345211-4ivqlsgt 16 37 patients patient NNS cord-345211-4ivqlsgt 16 38 [ [ -LRB- cord-345211-4ivqlsgt 16 39 4 4 CD cord-345211-4ivqlsgt 16 40 ] ] -RRB- cord-345211-4ivqlsgt 16 41 . . . cord-345211-4ivqlsgt 17 1 Indeed indeed RB cord-345211-4ivqlsgt 17 2 , , , cord-345211-4ivqlsgt 17 3 historically historically RB cord-345211-4ivqlsgt 17 4 , , , cord-345211-4ivqlsgt 17 5 we -PRON- PRP cord-345211-4ivqlsgt 17 6 have have VBP cord-345211-4ivqlsgt 17 7 been be VBN cord-345211-4ivqlsgt 17 8 unable unable JJ cord-345211-4ivqlsgt 17 9 to to TO cord-345211-4ivqlsgt 17 10 define define VB cord-345211-4ivqlsgt 17 11 a a DT cord-345211-4ivqlsgt 17 12 causative causative JJ cord-345211-4ivqlsgt 17 13 pathogen pathogen NN cord-345211-4ivqlsgt 17 14 in in IN cord-345211-4ivqlsgt 17 15 a a DT cord-345211-4ivqlsgt 17 16 significant significant JJ cord-345211-4ivqlsgt 17 17 proportion proportion NN cord-345211-4ivqlsgt 17 18 of of IN cord-345211-4ivqlsgt 17 19 pneumonia pneumonia NN cord-345211-4ivqlsgt 17 20 episodes episode NNS cord-345211-4ivqlsgt 17 21 , , , cord-345211-4ivqlsgt 17 22 even even RB cord-345211-4ivqlsgt 17 23 with with IN cord-345211-4ivqlsgt 17 24 the the DT cord-345211-4ivqlsgt 17 25 best good JJS cord-345211-4ivqlsgt 17 26 methods method NNS cord-345211-4ivqlsgt 17 27 . . . cord-345211-4ivqlsgt 18 1 Determining determine VBG cord-345211-4ivqlsgt 18 2 the the DT cord-345211-4ivqlsgt 18 3 microbial microbial JJ cord-345211-4ivqlsgt 18 4 etiology etiology NN cord-345211-4ivqlsgt 18 5 of of IN cord-345211-4ivqlsgt 18 6 pneumonia pneumonia NN cord-345211-4ivqlsgt 18 7 in in IN cord-345211-4ivqlsgt 18 8 children child NNS cord-345211-4ivqlsgt 18 9 has have VBZ cord-345211-4ivqlsgt 18 10 been be VBN cord-345211-4ivqlsgt 18 11 a a DT cord-345211-4ivqlsgt 18 12 particular particular JJ cord-345211-4ivqlsgt 18 13 challenge challenge NN cord-345211-4ivqlsgt 18 14 [ [ -LRB- cord-345211-4ivqlsgt 18 15 5 5 CD cord-345211-4ivqlsgt 18 16 ] ] -RRB- cord-345211-4ivqlsgt 18 17 . . . cord-345211-4ivqlsgt 19 1 The the DT cord-345211-4ivqlsgt 19 2 implications implication NNS cord-345211-4ivqlsgt 19 3 of of IN cord-345211-4ivqlsgt 19 4 poor poor JJ cord-345211-4ivqlsgt 19 5 pneumonia pneumonia NN cord-345211-4ivqlsgt 19 6 diagnostics diagnostic NNS cord-345211-4ivqlsgt 19 7 extend extend VBP cord-345211-4ivqlsgt 19 8 to to IN cord-345211-4ivqlsgt 19 9 the the DT cord-345211-4ivqlsgt 19 10 population population NN cord-345211-4ivqlsgt 19 11 level level NN cord-345211-4ivqlsgt 19 12 as as RB cord-345211-4ivqlsgt 19 13 well well RB cord-345211-4ivqlsgt 19 14 ; ; : cord-345211-4ivqlsgt 19 15 assessment assessment NN cord-345211-4ivqlsgt 19 16 of of IN cord-345211-4ivqlsgt 19 17 interventions intervention NNS cord-345211-4ivqlsgt 19 18 , , , cord-345211-4ivqlsgt 19 19 such such JJ cord-345211-4ivqlsgt 19 20 as as IN cord-345211-4ivqlsgt 19 21 vaccines vaccine NNS cord-345211-4ivqlsgt 19 22 , , , cord-345211-4ivqlsgt 19 23 is be VBZ cord-345211-4ivqlsgt 19 24 hindered hinder VBN cord-345211-4ivqlsgt 19 25 by by IN cord-345211-4ivqlsgt 19 26 suboptimal suboptimal JJ cord-345211-4ivqlsgt 19 27 measures measure NNS cord-345211-4ivqlsgt 19 28 of of IN cord-345211-4ivqlsgt 19 29 disease disease NN cord-345211-4ivqlsgt 19 30 impact impact NN cord-345211-4ivqlsgt 19 31 that that WDT cord-345211-4ivqlsgt 19 32 often often RB cord-345211-4ivqlsgt 19 33 rely rely VBP cord-345211-4ivqlsgt 19 34 on on IN cord-345211-4ivqlsgt 19 35 accurate accurate JJ cord-345211-4ivqlsgt 19 36 surveillance surveillance NN cord-345211-4ivqlsgt 19 37 data datum NNS cord-345211-4ivqlsgt 19 38 [ [ -LRB- cord-345211-4ivqlsgt 19 39 6 6 CD cord-345211-4ivqlsgt 19 40 ] ] -RRB- cord-345211-4ivqlsgt 19 41 . . . cord-345211-4ivqlsgt 20 1 Why why WRB cord-345211-4ivqlsgt 20 2 is be VBZ cord-345211-4ivqlsgt 20 3 it -PRON- PRP cord-345211-4ivqlsgt 20 4 so so RB cord-345211-4ivqlsgt 20 5 difficult difficult JJ cord-345211-4ivqlsgt 20 6 to to TO cord-345211-4ivqlsgt 20 7 determine determine VB cord-345211-4ivqlsgt 20 8 the the DT cord-345211-4ivqlsgt 20 9 microbial microbial JJ cord-345211-4ivqlsgt 20 10 etiology etiology NN cord-345211-4ivqlsgt 20 11 of of IN cord-345211-4ivqlsgt 20 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 20 13 ? ? . cord-345211-4ivqlsgt 21 1 The the DT cord-345211-4ivqlsgt 21 2 inability inability NN cord-345211-4ivqlsgt 21 3 to to TO cord-345211-4ivqlsgt 21 4 obtain obtain VB cord-345211-4ivqlsgt 21 5 good good JJ cord-345211-4ivqlsgt 21 6 quality quality NN cord-345211-4ivqlsgt 21 7 specimens specimen NNS cord-345211-4ivqlsgt 21 8 from from IN cord-345211-4ivqlsgt 21 9 the the DT cord-345211-4ivqlsgt 21 10 lower low JJR cord-345211-4ivqlsgt 21 11 respiratory respiratory JJ cord-345211-4ivqlsgt 21 12 tract tract NN cord-345211-4ivqlsgt 21 13 is be VBZ cord-345211-4ivqlsgt 21 14 one one CD cord-345211-4ivqlsgt 21 15 fundamental fundamental JJ cord-345211-4ivqlsgt 21 16 problem problem NN cord-345211-4ivqlsgt 21 17 with with IN cord-345211-4ivqlsgt 21 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 21 19 diagnostics diagnostic NNS cord-345211-4ivqlsgt 21 20 . . . cord-345211-4ivqlsgt 22 1 Whereas whereas IN cord-345211-4ivqlsgt 22 2 , , , cord-345211-4ivqlsgt 22 3 it -PRON- PRP cord-345211-4ivqlsgt 22 4 is be VBZ cord-345211-4ivqlsgt 22 5 relatively relatively RB cord-345211-4ivqlsgt 22 6 easy easy JJ cord-345211-4ivqlsgt 22 7 to to TO cord-345211-4ivqlsgt 22 8 get get VB cord-345211-4ivqlsgt 22 9 specimens specimen NNS cord-345211-4ivqlsgt 22 10 from from IN cord-345211-4ivqlsgt 22 11 the the DT cord-345211-4ivqlsgt 22 12 site site NN cord-345211-4ivqlsgt 22 13 of of IN cord-345211-4ivqlsgt 22 14 infection infection NN cord-345211-4ivqlsgt 22 15 with with IN cord-345211-4ivqlsgt 22 16 diseases disease NNS cord-345211-4ivqlsgt 22 17 such such JJ cord-345211-4ivqlsgt 22 18 as as IN cord-345211-4ivqlsgt 22 19 meningitis meningitis NN cord-345211-4ivqlsgt 22 20 , , , cord-345211-4ivqlsgt 22 21 gastroenteritis gastroenteritis NN cord-345211-4ivqlsgt 22 22 , , , cord-345211-4ivqlsgt 22 23 and and CC cord-345211-4ivqlsgt 22 24 endocarditis endocarditis NN cord-345211-4ivqlsgt 22 25 , , , cord-345211-4ivqlsgt 23 1 obtaining obtain VBG cord-345211-4ivqlsgt 23 2 representative representative JJ cord-345211-4ivqlsgt 23 3 and and CC cord-345211-4ivqlsgt 23 4 uncontaminated uncontaminated JJ cord-345211-4ivqlsgt 23 5 specimens specimen NNS cord-345211-4ivqlsgt 23 6 from from IN cord-345211-4ivqlsgt 23 7 the the DT cord-345211-4ivqlsgt 23 8 lungs lung NNS cord-345211-4ivqlsgt 23 9 in in IN cord-345211-4ivqlsgt 23 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 23 11 is be VBZ cord-345211-4ivqlsgt 23 12 a a DT cord-345211-4ivqlsgt 23 13 challenge challenge NN cord-345211-4ivqlsgt 23 14 . . . cord-345211-4ivqlsgt 24 1 Sputum Sputum NNP cord-345211-4ivqlsgt 24 2 and and CC cord-345211-4ivqlsgt 24 3 bronchoscopic bronchoscopic NNP cord-345211-4ivqlsgt 24 4 specimens specimen NNS cord-345211-4ivqlsgt 24 5 may may MD cord-345211-4ivqlsgt 24 6 be be VB cord-345211-4ivqlsgt 24 7 contaminated contaminate VBN cord-345211-4ivqlsgt 24 8 by by IN cord-345211-4ivqlsgt 24 9 normal normal JJ cord-345211-4ivqlsgt 24 10 respiratory respiratory JJ cord-345211-4ivqlsgt 24 11 flora flora NNS cord-345211-4ivqlsgt 24 12 , , , cord-345211-4ivqlsgt 24 13 and and CC cord-345211-4ivqlsgt 24 14 transthoracic transthoracic NNP cord-345211-4ivqlsgt 24 15 lung lung NNP cord-345211-4ivqlsgt 24 16 aspirates aspirate NNS cord-345211-4ivqlsgt 24 17 are be VBP cord-345211-4ivqlsgt 24 18 rarely rarely RB cord-345211-4ivqlsgt 24 19 performed perform VBN cord-345211-4ivqlsgt 24 20 despite despite IN cord-345211-4ivqlsgt 24 21 a a DT cord-345211-4ivqlsgt 24 22 good good JJ cord-345211-4ivqlsgt 24 23 safety safety NN cord-345211-4ivqlsgt 24 24 profile profile NN cord-345211-4ivqlsgt 24 25 [ [ -LRB- cord-345211-4ivqlsgt 24 26 7 7 CD cord-345211-4ivqlsgt 24 27 ] ] -RRB- cord-345211-4ivqlsgt 24 28 . . . cord-345211-4ivqlsgt 25 1 Instead instead RB cord-345211-4ivqlsgt 25 2 , , , cord-345211-4ivqlsgt 25 3 we -PRON- PRP cord-345211-4ivqlsgt 25 4 are be VBP cord-345211-4ivqlsgt 25 5 currently currently RB cord-345211-4ivqlsgt 25 6 reliant reliant JJ cord-345211-4ivqlsgt 25 7 on on IN cord-345211-4ivqlsgt 25 8 testing test VBG cord-345211-4ivqlsgt 25 9 more more RBR cord-345211-4ivqlsgt 25 10 distant distant JJ cord-345211-4ivqlsgt 25 11 clinical clinical JJ cord-345211-4ivqlsgt 25 12 specimens specimen NNS cord-345211-4ivqlsgt 25 13 , , , cord-345211-4ivqlsgt 25 14 particularly particularly RB cord-345211-4ivqlsgt 25 15 from from IN cord-345211-4ivqlsgt 25 16 the the DT cord-345211-4ivqlsgt 25 17 upper upper JJ cord-345211-4ivqlsgt 25 18 respiratory respiratory JJ cord-345211-4ivqlsgt 25 19 tract tract NN cord-345211-4ivqlsgt 25 20 , , , cord-345211-4ivqlsgt 25 21 blood blood NN cord-345211-4ivqlsgt 25 22 , , , cord-345211-4ivqlsgt 25 23 or or CC cord-345211-4ivqlsgt 25 24 urine urine NN cord-345211-4ivqlsgt 25 25 . . . cord-345211-4ivqlsgt 26 1 In in IN cord-345211-4ivqlsgt 26 2 general general JJ cord-345211-4ivqlsgt 26 3 , , , cord-345211-4ivqlsgt 26 4 testing test VBG cord-345211-4ivqlsgt 26 5 these these DT cord-345211-4ivqlsgt 26 6 specimens specimen NNS cord-345211-4ivqlsgt 26 7 has have VBZ cord-345211-4ivqlsgt 26 8 suboptimal suboptimal JJ cord-345211-4ivqlsgt 26 9 sensitivity sensitivity NN cord-345211-4ivqlsgt 26 10 and/or and/or CC cord-345211-4ivqlsgt 26 11 specificity specificity NN cord-345211-4ivqlsgt 26 12 for for IN cord-345211-4ivqlsgt 26 13 determining determine VBG cord-345211-4ivqlsgt 26 14 the the DT cord-345211-4ivqlsgt 26 15 microbial microbial JJ cord-345211-4ivqlsgt 26 16 etiology etiology NN cord-345211-4ivqlsgt 26 17 of of IN cord-345211-4ivqlsgt 26 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 26 19 with with IN cord-345211-4ivqlsgt 26 20 confidence confidence NN cord-345211-4ivqlsgt 26 21 . . . cord-345211-4ivqlsgt 27 1 A a DT cord-345211-4ivqlsgt 27 2 second second JJ cord-345211-4ivqlsgt 27 3 important important JJ cord-345211-4ivqlsgt 27 4 issue issue NN cord-345211-4ivqlsgt 27 5 hindering hinder VBG cord-345211-4ivqlsgt 27 6 our -PRON- PRP$ cord-345211-4ivqlsgt 27 7 ability ability NN cord-345211-4ivqlsgt 27 8 to to TO cord-345211-4ivqlsgt 27 9 determine determine VB cord-345211-4ivqlsgt 27 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 27 11 etiology etiology NN cord-345211-4ivqlsgt 27 12 is be VBZ cord-345211-4ivqlsgt 27 13 the the DT cord-345211-4ivqlsgt 27 14 fact fact NN cord-345211-4ivqlsgt 27 15 that that IN cord-345211-4ivqlsgt 27 16 some some DT cord-345211-4ivqlsgt 27 17 major major JJ cord-345211-4ivqlsgt 27 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 27 19 pathogens pathogen NNS cord-345211-4ivqlsgt 27 20 , , , cord-345211-4ivqlsgt 27 21 such such JJ cord-345211-4ivqlsgt 27 22 as as IN cord-345211-4ivqlsgt 27 23 Streptococcus streptococcus NN cord-345211-4ivqlsgt 27 24 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 27 25 , , , cord-345211-4ivqlsgt 27 26 Haemophilus haemophilus JJ cord-345211-4ivqlsgt 27 27 influenzae influenzae NN cord-345211-4ivqlsgt 27 28 , , , cord-345211-4ivqlsgt 27 29 and and CC cord-345211-4ivqlsgt 27 30 Staphylococcus Staphylococcus NNP cord-345211-4ivqlsgt 27 31 aureus aureus NN cord-345211-4ivqlsgt 27 32 , , , cord-345211-4ivqlsgt 27 33 may may MD cord-345211-4ivqlsgt 27 34 also also RB cord-345211-4ivqlsgt 27 35 asymptomatically asymptomatically RB cord-345211-4ivqlsgt 27 36 colonize colonize VB cord-345211-4ivqlsgt 27 37 the the DT cord-345211-4ivqlsgt 27 38 upper upper JJ cord-345211-4ivqlsgt 27 39 respiratory respiratory JJ cord-345211-4ivqlsgt 27 40 tract tract NN cord-345211-4ivqlsgt 27 41 as as IN cord-345211-4ivqlsgt 27 42 part part NN cord-345211-4ivqlsgt 27 43 of of IN cord-345211-4ivqlsgt 27 44 normal normal JJ cord-345211-4ivqlsgt 27 45 oropharyngeal oropharyngeal JJ cord-345211-4ivqlsgt 27 46 flora flora NNS cord-345211-4ivqlsgt 27 47 . . . cord-345211-4ivqlsgt 28 1 Consequently consequently RB cord-345211-4ivqlsgt 28 2 , , , cord-345211-4ivqlsgt 28 3 the the DT cord-345211-4ivqlsgt 28 4 detection detection NN cord-345211-4ivqlsgt 28 5 of of IN cord-345211-4ivqlsgt 28 6 these these DT cord-345211-4ivqlsgt 28 7 microorganisms microorganism NNS cord-345211-4ivqlsgt 28 8 is be VBZ cord-345211-4ivqlsgt 28 9 insufficient insufficient JJ cord-345211-4ivqlsgt 28 10 by by IN cord-345211-4ivqlsgt 28 11 itself -PRON- PRP cord-345211-4ivqlsgt 28 12 in in IN cord-345211-4ivqlsgt 28 13 order order NN cord-345211-4ivqlsgt 28 14 to to TO cord-345211-4ivqlsgt 28 15 attribute attribute VB cord-345211-4ivqlsgt 28 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 28 17 causation causation NN cord-345211-4ivqlsgt 28 18 . . . cord-345211-4ivqlsgt 29 1 This this DT cord-345211-4ivqlsgt 29 2 perspective perspective NN cord-345211-4ivqlsgt 29 3 reviews review VBZ cord-345211-4ivqlsgt 29 4 the the DT cord-345211-4ivqlsgt 29 5 current current JJ cord-345211-4ivqlsgt 29 6 use use NN cord-345211-4ivqlsgt 29 7 of of IN cord-345211-4ivqlsgt 29 8 molecular molecular JJ cord-345211-4ivqlsgt 29 9 diagnostics diagnostic NNS cord-345211-4ivqlsgt 29 10 for for IN cord-345211-4ivqlsgt 29 11 determining determine VBG cord-345211-4ivqlsgt 29 12 the the DT cord-345211-4ivqlsgt 29 13 microbial microbial JJ cord-345211-4ivqlsgt 29 14 etiology etiology NN cord-345211-4ivqlsgt 29 15 of of IN cord-345211-4ivqlsgt 29 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 29 17 and and CC cord-345211-4ivqlsgt 29 18 future future JJ cord-345211-4ivqlsgt 29 19 prospects prospect NNS cord-345211-4ivqlsgt 29 20 for for IN cord-345211-4ivqlsgt 29 21 this this DT cord-345211-4ivqlsgt 29 22 purpose purpose NN cord-345211-4ivqlsgt 29 23 . . . cord-345211-4ivqlsgt 30 1 The the DT cord-345211-4ivqlsgt 30 2 focus focus NN cord-345211-4ivqlsgt 30 3 is be VBZ cord-345211-4ivqlsgt 30 4 on on IN cord-345211-4ivqlsgt 30 5 recent recent JJ cord-345211-4ivqlsgt 30 6 advances advance NNS cord-345211-4ivqlsgt 30 7 and and CC cord-345211-4ivqlsgt 30 8 their -PRON- PRP$ cord-345211-4ivqlsgt 30 9 clinical clinical JJ cord-345211-4ivqlsgt 30 10 applications application NNS cord-345211-4ivqlsgt 30 11 rather rather RB cord-345211-4ivqlsgt 30 12 than than IN cord-345211-4ivqlsgt 30 13 detailed detailed JJ cord-345211-4ivqlsgt 30 14 description description NN cord-345211-4ivqlsgt 30 15 of of IN cord-345211-4ivqlsgt 30 16 specific specific JJ cord-345211-4ivqlsgt 30 17 technologies technology NNS cord-345211-4ivqlsgt 30 18 . . . cord-345211-4ivqlsgt 31 1 Presently presently RB cord-345211-4ivqlsgt 31 2 , , , cord-345211-4ivqlsgt 31 3 we -PRON- PRP cord-345211-4ivqlsgt 31 4 are be VBP cord-345211-4ivqlsgt 31 5 still still RB cord-345211-4ivqlsgt 31 6 reliant reliant JJ cord-345211-4ivqlsgt 31 7 on on IN cord-345211-4ivqlsgt 31 8 traditional traditional JJ cord-345211-4ivqlsgt 31 9 diagnostic diagnostic JJ cord-345211-4ivqlsgt 31 10 tools tool NNS cord-345211-4ivqlsgt 31 11 that that WDT cord-345211-4ivqlsgt 31 12 have have VBP cord-345211-4ivqlsgt 31 13 been be VBN cord-345211-4ivqlsgt 31 14 used use VBN cord-345211-4ivqlsgt 31 15 for for IN cord-345211-4ivqlsgt 31 16 decades decade NNS cord-345211-4ivqlsgt 31 17 to to TO cord-345211-4ivqlsgt 31 18 determine determine VB cord-345211-4ivqlsgt 31 19 the the DT cord-345211-4ivqlsgt 31 20 microbial microbial JJ cord-345211-4ivqlsgt 31 21 etiology etiology NN cord-345211-4ivqlsgt 31 22 of of IN cord-345211-4ivqlsgt 31 23 pneumonia pneumonia NN cord-345211-4ivqlsgt 31 24 . . . cord-345211-4ivqlsgt 32 1 Current current JJ cord-345211-4ivqlsgt 32 2 guidelines guideline NNS cord-345211-4ivqlsgt 32 3 for for IN cord-345211-4ivqlsgt 32 4 the the DT cord-345211-4ivqlsgt 32 5 management management NN cord-345211-4ivqlsgt 32 6 of of IN cord-345211-4ivqlsgt 32 7 community community NN cord-345211-4ivqlsgt 32 8 - - HYPH cord-345211-4ivqlsgt 32 9 acquired acquire VBN cord-345211-4ivqlsgt 32 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 32 11 in in IN cord-345211-4ivqlsgt 32 12 adults adult NNS cord-345211-4ivqlsgt 32 13 typically typically RB cord-345211-4ivqlsgt 32 14 recommend recommend VBP cord-345211-4ivqlsgt 32 15 that that IN cord-345211-4ivqlsgt 32 16 microbiologic microbiologic JJ cord-345211-4ivqlsgt 32 17 testing testing NN cord-345211-4ivqlsgt 32 18 should should MD cord-345211-4ivqlsgt 32 19 be be VB cord-345211-4ivqlsgt 32 20 largely largely RB cord-345211-4ivqlsgt 32 21 restricted restrict VBN cord-345211-4ivqlsgt 32 22 to to IN cord-345211-4ivqlsgt 32 23 patients patient NNS cord-345211-4ivqlsgt 32 24 with with IN cord-345211-4ivqlsgt 32 25 more more RBR cord-345211-4ivqlsgt 32 26 severe severe JJ cord-345211-4ivqlsgt 32 27 disease disease NN cord-345211-4ivqlsgt 32 28 , , , cord-345211-4ivqlsgt 32 29 and and CC cord-345211-4ivqlsgt 32 30 give give VB cord-345211-4ivqlsgt 32 31 guidance guidance NN cord-345211-4ivqlsgt 32 32 about about IN cord-345211-4ivqlsgt 32 33 the the DT cord-345211-4ivqlsgt 32 34 judicious judicious JJ cord-345211-4ivqlsgt 32 35 use use NN cord-345211-4ivqlsgt 32 36 of of IN cord-345211-4ivqlsgt 32 37 blood blood NN cord-345211-4ivqlsgt 32 38 cultures culture NNS cord-345211-4ivqlsgt 32 39 , , , cord-345211-4ivqlsgt 32 40 sputum sputum NN cord-345211-4ivqlsgt 32 41 microscopy microscopy NNS cord-345211-4ivqlsgt 32 42 and and CC cord-345211-4ivqlsgt 32 43 culture culture NN cord-345211-4ivqlsgt 32 44 , , , cord-345211-4ivqlsgt 32 45 urinary urinary JJ cord-345211-4ivqlsgt 32 46 antigen antigen NN cord-345211-4ivqlsgt 32 47 tests test NNS cord-345211-4ivqlsgt 32 48 , , , cord-345211-4ivqlsgt 32 49 and and CC cord-345211-4ivqlsgt 32 50 serology serology NN cord-345211-4ivqlsgt 32 51 [ [ -LRB- cord-345211-4ivqlsgt 32 52 8 8 CD cord-345211-4ivqlsgt 32 53 ] ] -RRB- cord-345211-4ivqlsgt 32 54 [ [ -LRB- cord-345211-4ivqlsgt 32 55 9 9 CD cord-345211-4ivqlsgt 32 56 ] ] -RRB- cord-345211-4ivqlsgt 32 57 [ [ -LRB- cord-345211-4ivqlsgt 32 58 10 10 CD cord-345211-4ivqlsgt 32 59 ] ] -RRB- cord-345211-4ivqlsgt 32 60 . . . cord-345211-4ivqlsgt 33 1 Guidelines guideline NNS cord-345211-4ivqlsgt 33 2 for for IN cord-345211-4ivqlsgt 33 3 the the DT cord-345211-4ivqlsgt 33 4 management management NN cord-345211-4ivqlsgt 33 5 of of IN cord-345211-4ivqlsgt 33 6 community community NN cord-345211-4ivqlsgt 33 7 - - HYPH cord-345211-4ivqlsgt 33 8 acquired acquire VBN cord-345211-4ivqlsgt 33 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 33 10 in in IN cord-345211-4ivqlsgt 33 11 children child NNS cord-345211-4ivqlsgt 33 12 are be VBP cord-345211-4ivqlsgt 33 13 even even RB cord-345211-4ivqlsgt 33 14 more more RBR cord-345211-4ivqlsgt 33 15 restrictive restrictive JJ cord-345211-4ivqlsgt 33 16 , , , cord-345211-4ivqlsgt 33 17 again again RB cord-345211-4ivqlsgt 33 18 recommending recommend VBG cord-345211-4ivqlsgt 33 19 that that IN cord-345211-4ivqlsgt 33 20 tests test NNS cord-345211-4ivqlsgt 33 21 should should MD cord-345211-4ivqlsgt 33 22 mainly mainly RB cord-345211-4ivqlsgt 33 23 be be VB cord-345211-4ivqlsgt 33 24 used use VBN cord-345211-4ivqlsgt 33 25 on on IN cord-345211-4ivqlsgt 33 26 patients patient NNS cord-345211-4ivqlsgt 33 27 with with IN cord-345211-4ivqlsgt 33 28 severe severe JJ cord-345211-4ivqlsgt 33 29 disease disease NN cord-345211-4ivqlsgt 33 30 , , , cord-345211-4ivqlsgt 33 31 with with IN cord-345211-4ivqlsgt 33 32 a a DT cord-345211-4ivqlsgt 33 33 focus focus NN cord-345211-4ivqlsgt 33 34 on on IN cord-345211-4ivqlsgt 33 35 blood blood NN cord-345211-4ivqlsgt 33 36 cultures culture NNS cord-345211-4ivqlsgt 33 37 and and CC cord-345211-4ivqlsgt 33 38 detection detection NN cord-345211-4ivqlsgt 33 39 of of IN cord-345211-4ivqlsgt 33 40 respiratory respiratory JJ cord-345211-4ivqlsgt 33 41 viruses virus NNS cord-345211-4ivqlsgt 33 42 [ [ -LRB- cord-345211-4ivqlsgt 33 43 11 11 CD cord-345211-4ivqlsgt 33 44 , , , cord-345211-4ivqlsgt 33 45 12 12 CD cord-345211-4ivqlsgt 33 46 ] ] -RRB- cord-345211-4ivqlsgt 33 47 . . . cord-345211-4ivqlsgt 34 1 Common common JJ cord-345211-4ivqlsgt 34 2 to to IN cord-345211-4ivqlsgt 34 3 these these DT cord-345211-4ivqlsgt 34 4 guidelines guideline NNS cord-345211-4ivqlsgt 34 5 is be VBZ cord-345211-4ivqlsgt 34 6 a a DT cord-345211-4ivqlsgt 34 7 cautious cautious JJ cord-345211-4ivqlsgt 34 8 approach approach NN cord-345211-4ivqlsgt 34 9 to to IN cord-345211-4ivqlsgt 34 10 the the DT cord-345211-4ivqlsgt 34 11 use use NN cord-345211-4ivqlsgt 34 12 of of IN cord-345211-4ivqlsgt 34 13 molecular molecular JJ cord-345211-4ivqlsgt 34 14 diagnostics diagnostic NNS cord-345211-4ivqlsgt 34 15 , , , cord-345211-4ivqlsgt 34 16 although although IN cord-345211-4ivqlsgt 34 17 this this DT cord-345211-4ivqlsgt 34 18 may may MD cord-345211-4ivqlsgt 34 19 change change VB cord-345211-4ivqlsgt 34 20 with with IN cord-345211-4ivqlsgt 34 21 ongoing ongoing JJ cord-345211-4ivqlsgt 34 22 reviews review NNS cord-345211-4ivqlsgt 34 23 . . . cord-345211-4ivqlsgt 35 1 This this DT cord-345211-4ivqlsgt 35 2 caution caution NN cord-345211-4ivqlsgt 35 3 is be VBZ cord-345211-4ivqlsgt 35 4 driven drive VBN cord-345211-4ivqlsgt 35 5 partly partly RB cord-345211-4ivqlsgt 35 6 by by IN cord-345211-4ivqlsgt 35 7 the the DT cord-345211-4ivqlsgt 35 8 perceived perceive VBN cord-345211-4ivqlsgt 35 9 and and CC cord-345211-4ivqlsgt 35 10 real real JJ cord-345211-4ivqlsgt 35 11 lack lack NN cord-345211-4ivqlsgt 35 12 of of IN cord-345211-4ivqlsgt 35 13 commercial commercial JJ cord-345211-4ivqlsgt 35 14 and and CC cord-345211-4ivqlsgt 35 15 standardized standardized JJ cord-345211-4ivqlsgt 35 16 assays assay NNS cord-345211-4ivqlsgt 35 17 and and CC cord-345211-4ivqlsgt 35 18 partly partly RB cord-345211-4ivqlsgt 35 19 by by IN cord-345211-4ivqlsgt 35 20 lack lack NN cord-345211-4ivqlsgt 35 21 of of IN cord-345211-4ivqlsgt 35 22 good good JJ cord-345211-4ivqlsgt 35 23 data datum NNS cord-345211-4ivqlsgt 35 24 on on IN cord-345211-4ivqlsgt 35 25 diagnostic diagnostic JJ cord-345211-4ivqlsgt 35 26 accuracy accuracy NN cord-345211-4ivqlsgt 35 27 . . . cord-345211-4ivqlsgt 36 1 There there EX cord-345211-4ivqlsgt 36 2 is be VBZ cord-345211-4ivqlsgt 36 3 also also RB cord-345211-4ivqlsgt 36 4 a a DT cord-345211-4ivqlsgt 36 5 lingering linger VBG cord-345211-4ivqlsgt 36 6 perception perception NN cord-345211-4ivqlsgt 36 7 that that IN cord-345211-4ivqlsgt 36 8 molecular molecular JJ cord-345211-4ivqlsgt 36 9 diagnostics diagnostic NNS cord-345211-4ivqlsgt 36 10 are be VBP cord-345211-4ivqlsgt 36 11 expensive expensive JJ cord-345211-4ivqlsgt 36 12 tests test NNS cord-345211-4ivqlsgt 36 13 and and CC cord-345211-4ivqlsgt 36 14 that that IN cord-345211-4ivqlsgt 36 15 use use NN cord-345211-4ivqlsgt 36 16 should should MD cord-345211-4ivqlsgt 36 17 be be VB cord-345211-4ivqlsgt 36 18 restricted restrict VBN cord-345211-4ivqlsgt 36 19 on on IN cord-345211-4ivqlsgt 36 20 this this DT cord-345211-4ivqlsgt 36 21 basis basis NN cord-345211-4ivqlsgt 36 22 . . . cord-345211-4ivqlsgt 37 1 Cost cost NN cord-345211-4ivqlsgt 37 2 is be VBZ cord-345211-4ivqlsgt 37 3 not not RB cord-345211-4ivqlsgt 37 4 the the DT cord-345211-4ivqlsgt 37 5 barrier barrier NN cord-345211-4ivqlsgt 37 6 it -PRON- PRP cord-345211-4ivqlsgt 37 7 used use VBD cord-345211-4ivqlsgt 37 8 to to TO cord-345211-4ivqlsgt 37 9 be be VB cord-345211-4ivqlsgt 37 10 , , , cord-345211-4ivqlsgt 37 11 and and CC cord-345211-4ivqlsgt 37 12 the the DT cord-345211-4ivqlsgt 37 13 relative relative JJ cord-345211-4ivqlsgt 37 14 price price NN cord-345211-4ivqlsgt 37 15 of of IN cord-345211-4ivqlsgt 37 16 molecular molecular JJ cord-345211-4ivqlsgt 37 17 diagnostics diagnostic NNS cord-345211-4ivqlsgt 37 18 has have VBZ cord-345211-4ivqlsgt 37 19 actually actually RB cord-345211-4ivqlsgt 37 20 fallen fall VBN cord-345211-4ivqlsgt 37 21 over over IN cord-345211-4ivqlsgt 37 22 recent recent JJ cord-345211-4ivqlsgt 37 23 years year NNS cord-345211-4ivqlsgt 37 24 . . . cord-345211-4ivqlsgt 38 1 Indeed indeed RB cord-345211-4ivqlsgt 38 2 , , , cord-345211-4ivqlsgt 38 3 many many JJ cord-345211-4ivqlsgt 38 4 molecular molecular JJ cord-345211-4ivqlsgt 38 5 assays assay NNS cord-345211-4ivqlsgt 38 6 are be VBP cord-345211-4ivqlsgt 38 7 now now RB cord-345211-4ivqlsgt 38 8 comparable comparable JJ cord-345211-4ivqlsgt 38 9 in in IN cord-345211-4ivqlsgt 38 10 cost cost NN cord-345211-4ivqlsgt 38 11 to to IN cord-345211-4ivqlsgt 38 12 conventional conventional JJ cord-345211-4ivqlsgt 38 13 culture culture NN cord-345211-4ivqlsgt 38 14 - - HYPH cord-345211-4ivqlsgt 38 15 based base VBN cord-345211-4ivqlsgt 38 16 methods method NNS cord-345211-4ivqlsgt 38 17 . . . cord-345211-4ivqlsgt 39 1 Molecular molecular JJ cord-345211-4ivqlsgt 39 2 methods method NNS cord-345211-4ivqlsgt 39 3 have have VBP cord-345211-4ivqlsgt 39 4 been be VBN cord-345211-4ivqlsgt 39 5 a a DT cord-345211-4ivqlsgt 39 6 particularly particularly RB cord-345211-4ivqlsgt 39 7 welcome welcome JJ cord-345211-4ivqlsgt 39 8 addition addition NN cord-345211-4ivqlsgt 39 9 to to IN cord-345211-4ivqlsgt 39 10 the the DT cord-345211-4ivqlsgt 39 11 pneumonia pneumonia NN cord-345211-4ivqlsgt 39 12 diagnostic diagnostic JJ cord-345211-4ivqlsgt 39 13 toolbox toolbox NN cord-345211-4ivqlsgt 39 14 . . . cord-345211-4ivqlsgt 40 1 Collectively collectively RB cord-345211-4ivqlsgt 40 2 , , , cord-345211-4ivqlsgt 40 3 they -PRON- PRP cord-345211-4ivqlsgt 40 4 represent represent VBP cord-345211-4ivqlsgt 40 5 the the DT cord-345211-4ivqlsgt 40 6 single single JJ cord-345211-4ivqlsgt 40 7 biggest big JJS cord-345211-4ivqlsgt 40 8 recent recent JJ cord-345211-4ivqlsgt 40 9 advance advance NN cord-345211-4ivqlsgt 40 10 in in IN cord-345211-4ivqlsgt 40 11 the the DT cord-345211-4ivqlsgt 40 12 field field NN cord-345211-4ivqlsgt 40 13 . . . cord-345211-4ivqlsgt 41 1 While while IN cord-345211-4ivqlsgt 41 2 not not RB cord-345211-4ivqlsgt 41 3 exactly exactly RB cord-345211-4ivqlsgt 41 4 new new JJ cord-345211-4ivqlsgt 41 5 ( ( -LRB- cord-345211-4ivqlsgt 41 6 polymerase polymerase NN cord-345211-4ivqlsgt 41 7 chain chain NN cord-345211-4ivqlsgt 41 8 reaction reaction NN cord-345211-4ivqlsgt 41 9 ( ( -LRB- cord-345211-4ivqlsgt 41 10 PCR PCR NNP cord-345211-4ivqlsgt 41 11 ) ) -RRB- cord-345211-4ivqlsgt 41 12 assays assay NNS cord-345211-4ivqlsgt 41 13 for for IN cord-345211-4ivqlsgt 41 14 respiratory respiratory JJ cord-345211-4ivqlsgt 41 15 pathogens pathogen NNS cord-345211-4ivqlsgt 41 16 have have VBP cord-345211-4ivqlsgt 41 17 been be VBN cord-345211-4ivqlsgt 41 18 around around RB cord-345211-4ivqlsgt 41 19 for for IN cord-345211-4ivqlsgt 41 20 over over IN cord-345211-4ivqlsgt 41 21 20 20 CD cord-345211-4ivqlsgt 41 22 years year NNS cord-345211-4ivqlsgt 41 23 ) ) -RRB- cord-345211-4ivqlsgt 41 24 , , , cord-345211-4ivqlsgt 41 25 the the DT cord-345211-4ivqlsgt 41 26 widespread widespread JJ cord-345211-4ivqlsgt 41 27 adoption adoption NN cord-345211-4ivqlsgt 41 28 of of IN cord-345211-4ivqlsgt 41 29 nucleic nucleic JJ cord-345211-4ivqlsgt 41 30 acid acid NN cord-345211-4ivqlsgt 41 31 detection detection NN cord-345211-4ivqlsgt 41 32 tests test NNS cord-345211-4ivqlsgt 41 33 ( ( -LRB- cord-345211-4ivqlsgt 41 34 NATs NATs NNP cord-345211-4ivqlsgt 41 35 ) ) -RRB- cord-345211-4ivqlsgt 41 36 by by IN cord-345211-4ivqlsgt 41 37 diagnostic diagnostic JJ cord-345211-4ivqlsgt 41 38 laboratories laboratory NNS cord-345211-4ivqlsgt 41 39 has have VBZ cord-345211-4ivqlsgt 41 40 been be VBN cord-345211-4ivqlsgt 41 41 relatively relatively RB cord-345211-4ivqlsgt 41 42 slow slow JJ cord-345211-4ivqlsgt 41 43 . . . cord-345211-4ivqlsgt 42 1 This this DT cord-345211-4ivqlsgt 42 2 contrasts contrast VBZ cord-345211-4ivqlsgt 42 3 to to IN cord-345211-4ivqlsgt 42 4 NATs NATs NNP cord-345211-4ivqlsgt 42 5 for for IN cord-345211-4ivqlsgt 42 6 other other JJ cord-345211-4ivqlsgt 42 7 infectious infectious JJ cord-345211-4ivqlsgt 42 8 diseases disease NNS cord-345211-4ivqlsgt 42 9 , , , cord-345211-4ivqlsgt 42 10 which which WDT cord-345211-4ivqlsgt 42 11 have have VBP cord-345211-4ivqlsgt 42 12 been be VBN cord-345211-4ivqlsgt 42 13 more more RBR cord-345211-4ivqlsgt 42 14 quickly quickly RB cord-345211-4ivqlsgt 42 15 embraced embrace VBN cord-345211-4ivqlsgt 42 16 by by IN cord-345211-4ivqlsgt 42 17 laboratories laboratory NNS cord-345211-4ivqlsgt 42 18 and and CC cord-345211-4ivqlsgt 42 19 clinicians clinician NNS cord-345211-4ivqlsgt 42 20 [ [ -LRB- cord-345211-4ivqlsgt 42 21 13 13 CD cord-345211-4ivqlsgt 42 22 ] ] -RRB- cord-345211-4ivqlsgt 42 23 . . . cord-345211-4ivqlsgt 43 1 A a DT cord-345211-4ivqlsgt 43 2 major major JJ cord-345211-4ivqlsgt 43 3 reason reason NN cord-345211-4ivqlsgt 43 4 for for IN cord-345211-4ivqlsgt 43 5 the the DT cord-345211-4ivqlsgt 43 6 slow slow JJ cord-345211-4ivqlsgt 43 7 uptake uptake NN cord-345211-4ivqlsgt 43 8 and and CC cord-345211-4ivqlsgt 43 9 acceptance acceptance NN cord-345211-4ivqlsgt 43 10 of of IN cord-345211-4ivqlsgt 43 11 respiratory respiratory JJ cord-345211-4ivqlsgt 43 12 NATs nat NNS cord-345211-4ivqlsgt 43 13 has have VBZ cord-345211-4ivqlsgt 43 14 been be VBN cord-345211-4ivqlsgt 43 15 the the DT cord-345211-4ivqlsgt 43 16 lack lack NN cord-345211-4ivqlsgt 43 17 of of IN cord-345211-4ivqlsgt 43 18 commercial commercial JJ cord-345211-4ivqlsgt 43 19 assays assay NNS cord-345211-4ivqlsgt 43 20 . . . cord-345211-4ivqlsgt 44 1 This this DT cord-345211-4ivqlsgt 44 2 situation situation NN cord-345211-4ivqlsgt 44 3 is be VBZ cord-345211-4ivqlsgt 44 4 changing change VBG cord-345211-4ivqlsgt 44 5 rapidly rapidly RB cord-345211-4ivqlsgt 44 6 , , , cord-345211-4ivqlsgt 44 7 undoubtedly undoubtedly RB cord-345211-4ivqlsgt 44 8 spurred spur VBN cord-345211-4ivqlsgt 44 9 on on RP cord-345211-4ivqlsgt 44 10 by by IN cord-345211-4ivqlsgt 44 11 recent recent JJ cord-345211-4ivqlsgt 44 12 outbreaks outbreak NNS cord-345211-4ivqlsgt 44 13 of of IN cord-345211-4ivqlsgt 44 14 global global JJ cord-345211-4ivqlsgt 44 15 concern concern NN cord-345211-4ivqlsgt 44 16 , , , cord-345211-4ivqlsgt 44 17 such such JJ cord-345211-4ivqlsgt 44 18 as as IN cord-345211-4ivqlsgt 44 19 pandemic pandemic NN cord-345211-4ivqlsgt 44 20 influenza influenza NN cord-345211-4ivqlsgt 44 21 , , , cord-345211-4ivqlsgt 44 22 Middle Middle NNP cord-345211-4ivqlsgt 44 23 East East NNP cord-345211-4ivqlsgt 44 24 respiratory respiratory JJ cord-345211-4ivqlsgt 44 25 syndrome syndrome NN cord-345211-4ivqlsgt 44 26 ( ( -LRB- cord-345211-4ivqlsgt 44 27 MERS MERS NNP cord-345211-4ivqlsgt 44 28 ) ) -RRB- cord-345211-4ivqlsgt 44 29 , , , cord-345211-4ivqlsgt 44 30 and and CC cord-345211-4ivqlsgt 44 31 Ebola Ebola NNP cord-345211-4ivqlsgt 44 32 [ [ -LRB- cord-345211-4ivqlsgt 44 33 14 14 CD cord-345211-4ivqlsgt 44 34 ] ] -RRB- cord-345211-4ivqlsgt 44 35 [ [ -LRB- cord-345211-4ivqlsgt 44 36 15 15 CD cord-345211-4ivqlsgt 44 37 ] ] -RRB- cord-345211-4ivqlsgt 44 38 [ [ -LRB- cord-345211-4ivqlsgt 44 39 16 16 CD cord-345211-4ivqlsgt 44 40 ] ] -RRB- cord-345211-4ivqlsgt 44 41 . . . cord-345211-4ivqlsgt 45 1 Indeed indeed RB cord-345211-4ivqlsgt 45 2 , , , cord-345211-4ivqlsgt 45 3 the the DT cord-345211-4ivqlsgt 45 4 increased increase VBN cord-345211-4ivqlsgt 45 5 availability availability NN cord-345211-4ivqlsgt 45 6 of of IN cord-345211-4ivqlsgt 45 7 commercial commercial JJ cord-345211-4ivqlsgt 45 8 assays assay NNS cord-345211-4ivqlsgt 45 9 is be VBZ cord-345211-4ivqlsgt 45 10 the the DT cord-345211-4ivqlsgt 45 11 major major JJ cord-345211-4ivqlsgt 45 12 change change NN cord-345211-4ivqlsgt 45 13 in in IN cord-345211-4ivqlsgt 45 14 the the DT cord-345211-4ivqlsgt 45 15 area area NN cord-345211-4ivqlsgt 45 16 since since IN cord-345211-4ivqlsgt 45 17 I -PRON- PRP cord-345211-4ivqlsgt 45 18 first first RB cord-345211-4ivqlsgt 45 19 started start VBD cord-345211-4ivqlsgt 45 20 reviewing review VBG cord-345211-4ivqlsgt 45 21 the the DT cord-345211-4ivqlsgt 45 22 role role NN cord-345211-4ivqlsgt 45 23 of of IN cord-345211-4ivqlsgt 45 24 molecular molecular JJ cord-345211-4ivqlsgt 45 25 diagnostics diagnostic NNS cord-345211-4ivqlsgt 45 26 in in IN cord-345211-4ivqlsgt 45 27 pneumonia pneumonia NN cord-345211-4ivqlsgt 45 28 over over IN cord-345211-4ivqlsgt 45 29 10 10 CD cord-345211-4ivqlsgt 45 30 years year NNS cord-345211-4ivqlsgt 45 31 ago ago RB cord-345211-4ivqlsgt 45 32 [ [ -LRB- cord-345211-4ivqlsgt 45 33 17 17 CD cord-345211-4ivqlsgt 45 34 , , , cord-345211-4ivqlsgt 45 35 18 18 CD cord-345211-4ivqlsgt 45 36 ] ] -RRB- cord-345211-4ivqlsgt 45 37 . . . cord-345211-4ivqlsgt 46 1 To to IN cord-345211-4ivqlsgt 46 2 date date NN cord-345211-4ivqlsgt 46 3 , , , cord-345211-4ivqlsgt 46 4 molecular molecular JJ cord-345211-4ivqlsgt 46 5 tests test NNS cord-345211-4ivqlsgt 46 6 for for IN cord-345211-4ivqlsgt 46 7 pneumonia pneumonia NN cord-345211-4ivqlsgt 46 8 have have VBP cord-345211-4ivqlsgt 46 9 mainly mainly RB cord-345211-4ivqlsgt 46 10 focused focus VBN cord-345211-4ivqlsgt 46 11 on on IN cord-345211-4ivqlsgt 46 12 detection detection NN cord-345211-4ivqlsgt 46 13 of of IN cord-345211-4ivqlsgt 46 14 specific specific JJ cord-345211-4ivqlsgt 46 15 known know VBN cord-345211-4ivqlsgt 46 16 pathogens pathogen NNS cord-345211-4ivqlsgt 46 17 by by IN cord-345211-4ivqlsgt 46 18 NATs NATs NNP cord-345211-4ivqlsgt 46 19 . . . cord-345211-4ivqlsgt 47 1 NATs nat NNS cord-345211-4ivqlsgt 47 2 have have VBP cord-345211-4ivqlsgt 47 3 several several JJ cord-345211-4ivqlsgt 47 4 advantages advantage NNS cord-345211-4ivqlsgt 47 5 over over IN cord-345211-4ivqlsgt 47 6 other other JJ cord-345211-4ivqlsgt 47 7 existing exist VBG cord-345211-4ivqlsgt 47 8 diagnostic diagnostic JJ cord-345211-4ivqlsgt 47 9 tools tool NNS cord-345211-4ivqlsgt 47 10 . . . cord-345211-4ivqlsgt 48 1 They -PRON- PRP cord-345211-4ivqlsgt 48 2 potentially potentially RB cord-345211-4ivqlsgt 48 3 detect detect VBP cord-345211-4ivqlsgt 48 4 low low JJ cord-345211-4ivqlsgt 48 5 levels level NNS cord-345211-4ivqlsgt 48 6 of of IN cord-345211-4ivqlsgt 48 7 all all RB cord-345211-4ivqlsgt 48 8 - - HYPH cord-345211-4ivqlsgt 48 9 known know VBN cord-345211-4ivqlsgt 48 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 48 11 pathogens pathogen NNS cord-345211-4ivqlsgt 48 12 in in IN cord-345211-4ivqlsgt 48 13 clinical clinical JJ cord-345211-4ivqlsgt 48 14 specimens specimen NNS cord-345211-4ivqlsgt 48 15 , , , cord-345211-4ivqlsgt 48 16 do do VBP cord-345211-4ivqlsgt 48 17 not not RB cord-345211-4ivqlsgt 48 18 depend depend VB cord-345211-4ivqlsgt 48 19 on on IN cord-345211-4ivqlsgt 48 20 the the DT cord-345211-4ivqlsgt 48 21 viability viability NN cord-345211-4ivqlsgt 48 22 of of IN cord-345211-4ivqlsgt 48 23 the the DT cord-345211-4ivqlsgt 48 24 target target NN cord-345211-4ivqlsgt 48 25 microbe microbe NN cord-345211-4ivqlsgt 48 26 , , , cord-345211-4ivqlsgt 48 27 and and CC cord-345211-4ivqlsgt 48 28 can can MD cord-345211-4ivqlsgt 48 29 provide provide VB cord-345211-4ivqlsgt 48 30 results result NNS cord-345211-4ivqlsgt 48 31 within within IN cord-345211-4ivqlsgt 48 32 a a DT cord-345211-4ivqlsgt 48 33 clinically clinically RB cord-345211-4ivqlsgt 48 34 relevant relevant JJ cord-345211-4ivqlsgt 48 35 time time NN cord-345211-4ivqlsgt 48 36 frame frame NN cord-345211-4ivqlsgt 48 37 . . . cord-345211-4ivqlsgt 49 1 They -PRON- PRP cord-345211-4ivqlsgt 49 2 are be VBP cord-345211-4ivqlsgt 49 3 also also RB cord-345211-4ivqlsgt 49 4 probably probably RB cord-345211-4ivqlsgt 49 5 less less RBR cord-345211-4ivqlsgt 49 6 affected affect VBN cord-345211-4ivqlsgt 49 7 by by IN cord-345211-4ivqlsgt 49 8 previous previous JJ cord-345211-4ivqlsgt 49 9 antimicrobial antimicrobial JJ cord-345211-4ivqlsgt 49 10 therapy therapy NN cord-345211-4ivqlsgt 49 11 than than IN cord-345211-4ivqlsgt 49 12 are be VBP cord-345211-4ivqlsgt 49 13 culturebased culturebase VBN cord-345211-4ivqlsgt 49 14 diagnostic diagnostic JJ cord-345211-4ivqlsgt 49 15 methods method NNS cord-345211-4ivqlsgt 49 16 . . . cord-345211-4ivqlsgt 50 1 There there EX cord-345211-4ivqlsgt 50 2 are be VBP cord-345211-4ivqlsgt 50 3 now now RB cord-345211-4ivqlsgt 50 4 a a DT cord-345211-4ivqlsgt 50 5 wide wide JJ cord-345211-4ivqlsgt 50 6 variety variety NN cord-345211-4ivqlsgt 50 7 of of IN cord-345211-4ivqlsgt 50 8 user user NN cord-345211-4ivqlsgt 50 9 - - HYPH cord-345211-4ivqlsgt 50 10 friendly friendly JJ cord-345211-4ivqlsgt 50 11 platforms platform NNS cord-345211-4ivqlsgt 50 12 that that WDT cord-345211-4ivqlsgt 50 13 have have VBP cord-345211-4ivqlsgt 50 14 enabled enable VBN cord-345211-4ivqlsgt 50 15 NATs nat NNS cord-345211-4ivqlsgt 50 16 to to TO cord-345211-4ivqlsgt 50 17 be be VB cord-345211-4ivqlsgt 50 18 deployed deploy VBN cord-345211-4ivqlsgt 50 19 in in IN cord-345211-4ivqlsgt 50 20 laboratories laboratory NNS cord-345211-4ivqlsgt 50 21 outside outside RB cord-345211-4ivqlsgt 50 22 of of IN cord-345211-4ivqlsgt 50 23 specialist specialist JJ cord-345211-4ivqlsgt 50 24 tertiary tertiary JJ cord-345211-4ivqlsgt 50 25 referral referral NN cord-345211-4ivqlsgt 50 26 centers center NNS cord-345211-4ivqlsgt 50 27 . . . cord-345211-4ivqlsgt 51 1 Although although IN cord-345211-4ivqlsgt 51 2 NATs nat NNS cord-345211-4ivqlsgt 51 3 have have VBP cord-345211-4ivqlsgt 51 4 mainly mainly RB cord-345211-4ivqlsgt 51 5 focused focus VBN cord-345211-4ivqlsgt 51 6 on on IN cord-345211-4ivqlsgt 51 7 detecting detect VBG cord-345211-4ivqlsgt 51 8 the the DT cord-345211-4ivqlsgt 51 9 presence presence NN cord-345211-4ivqlsgt 51 10 of of IN cord-345211-4ivqlsgt 51 11 a a DT cord-345211-4ivqlsgt 51 12 particular particular JJ cord-345211-4ivqlsgt 51 13 microorganism microorganism NN cord-345211-4ivqlsgt 51 14 , , , cord-345211-4ivqlsgt 51 15 they -PRON- PRP cord-345211-4ivqlsgt 51 16 may may MD cord-345211-4ivqlsgt 51 17 also also RB cord-345211-4ivqlsgt 51 18 provide provide VB cord-345211-4ivqlsgt 51 19 additional additional JJ cord-345211-4ivqlsgt 51 20 information information NN cord-345211-4ivqlsgt 51 21 , , , cord-345211-4ivqlsgt 51 22 such such JJ cord-345211-4ivqlsgt 51 23 as as IN cord-345211-4ivqlsgt 51 24 data datum NNS cord-345211-4ivqlsgt 51 25 on on IN cord-345211-4ivqlsgt 51 26 antimicrobial antimicrobial JJ cord-345211-4ivqlsgt 51 27 resistance resistance NN cord-345211-4ivqlsgt 51 28 and and CC cord-345211-4ivqlsgt 51 29 strain strain NN cord-345211-4ivqlsgt 51 30 typing typing NN cord-345211-4ivqlsgt 51 31 . . . cord-345211-4ivqlsgt 52 1 The the DT cord-345211-4ivqlsgt 52 2 NATs nat NNS cord-345211-4ivqlsgt 52 3 that that WDT cord-345211-4ivqlsgt 52 4 are be VBP cord-345211-4ivqlsgt 52 5 most most RBS cord-345211-4ivqlsgt 52 6 widely widely RB cord-345211-4ivqlsgt 52 7 used use VBN cord-345211-4ivqlsgt 52 8 in in IN cord-345211-4ivqlsgt 52 9 diagnostic diagnostic JJ cord-345211-4ivqlsgt 52 10 laboratories laboratory NNS cord-345211-4ivqlsgt 52 11 are be VBP cord-345211-4ivqlsgt 52 12 those those DT cord-345211-4ivqlsgt 52 13 that that WDT cord-345211-4ivqlsgt 52 14 detect detect VBP cord-345211-4ivqlsgt 52 15 potential potential JJ cord-345211-4ivqlsgt 52 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 52 17 pathogens pathogen NNS cord-345211-4ivqlsgt 52 18 that that WDT cord-345211-4ivqlsgt 52 19 are be VBP cord-345211-4ivqlsgt 52 20 not not RB cord-345211-4ivqlsgt 52 21 part part NN cord-345211-4ivqlsgt 52 22 of of IN cord-345211-4ivqlsgt 52 23 the the DT cord-345211-4ivqlsgt 52 24 normal normal JJ cord-345211-4ivqlsgt 52 25 flora flora NNS cord-345211-4ivqlsgt 52 26 , , , cord-345211-4ivqlsgt 52 27 namely namely RB cord-345211-4ivqlsgt 52 28 respiratory respiratory JJ cord-345211-4ivqlsgt 52 29 viruses virus NNS cord-345211-4ivqlsgt 52 30 and and CC cord-345211-4ivqlsgt 52 31 selected select VBN cord-345211-4ivqlsgt 52 32 non non JJ cord-345211-4ivqlsgt 52 33 - - JJ cord-345211-4ivqlsgt 52 34 colonizing colonizing JJ cord-345211-4ivqlsgt 52 35 bacteria bacteria NNS cord-345211-4ivqlsgt 52 36 . . . cord-345211-4ivqlsgt 53 1 For for IN cord-345211-4ivqlsgt 53 2 these these DT cord-345211-4ivqlsgt 53 3 microbes microbe NNS cord-345211-4ivqlsgt 53 4 , , , cord-345211-4ivqlsgt 53 5 simply simply RB cord-345211-4ivqlsgt 53 6 detecting detect VBG cord-345211-4ivqlsgt 53 7 their -PRON- PRP$ cord-345211-4ivqlsgt 53 8 presence presence NN cord-345211-4ivqlsgt 53 9 in in IN cord-345211-4ivqlsgt 53 10 a a DT cord-345211-4ivqlsgt 53 11 respiratory respiratory JJ cord-345211-4ivqlsgt 53 12 sample sample NN cord-345211-4ivqlsgt 53 13 has have VBZ cord-345211-4ivqlsgt 53 14 been be VBN cord-345211-4ivqlsgt 53 15 regarded regard VBN cord-345211-4ivqlsgt 53 16 as as IN cord-345211-4ivqlsgt 53 17 sufficient sufficient JJ cord-345211-4ivqlsgt 53 18 evidence evidence NN cord-345211-4ivqlsgt 53 19 to to TO cord-345211-4ivqlsgt 53 20 assign assign VB cord-345211-4ivqlsgt 53 21 causation causation NN cord-345211-4ivqlsgt 53 22 . . . cord-345211-4ivqlsgt 54 1 In in IN cord-345211-4ivqlsgt 54 2 contrast contrast NN cord-345211-4ivqlsgt 54 3 , , , cord-345211-4ivqlsgt 54 4 NATs NATs NNP cord-345211-4ivqlsgt 54 5 for for IN cord-345211-4ivqlsgt 54 6 other other JJ cord-345211-4ivqlsgt 54 7 bacteria bacteria NNS cord-345211-4ivqlsgt 54 8 , , , cord-345211-4ivqlsgt 54 9 including include VBG cord-345211-4ivqlsgt 54 10 some some DT cord-345211-4ivqlsgt 54 11 of of IN cord-345211-4ivqlsgt 54 12 the the DT cord-345211-4ivqlsgt 54 13 most most RBS cord-345211-4ivqlsgt 54 14 important important JJ cord-345211-4ivqlsgt 54 15 pneumonia pneumonia NN cord-345211-4ivqlsgt 54 16 pathogens pathogen NNS cord-345211-4ivqlsgt 54 17 , , , cord-345211-4ivqlsgt 54 18 have have VBP cord-345211-4ivqlsgt 54 19 struggled struggle VBN cord-345211-4ivqlsgt 54 20 for for IN cord-345211-4ivqlsgt 54 21 a a DT cord-345211-4ivqlsgt 54 22 defined define VBN cord-345211-4ivqlsgt 54 23 role role NN cord-345211-4ivqlsgt 54 24 outside outside IN cord-345211-4ivqlsgt 54 25 research research NN cord-345211-4ivqlsgt 54 26 laboratories laboratory NNS cord-345211-4ivqlsgt 54 27 . . . cord-345211-4ivqlsgt 55 1 NATs NATs NNP cord-345211-4ivqlsgt 55 2 for for IN cord-345211-4ivqlsgt 55 3 detection detection NN cord-345211-4ivqlsgt 55 4 of of IN cord-345211-4ivqlsgt 55 5 the the DT cord-345211-4ivqlsgt 55 6 following follow VBG cord-345211-4ivqlsgt 55 7 respiratory respiratory JJ cord-345211-4ivqlsgt 55 8 pathogens pathogen NNS cord-345211-4ivqlsgt 55 9 now now RB cord-345211-4ivqlsgt 55 10 have have VBP cord-345211-4ivqlsgt 55 11 established establish VBN cord-345211-4ivqlsgt 55 12 roles role NNS cord-345211-4ivqlsgt 55 13 . . . cord-345211-4ivqlsgt 56 1 NATs nat NNS cord-345211-4ivqlsgt 56 2 have have VBP cord-345211-4ivqlsgt 56 3 revolutionized revolutionize VBN cord-345211-4ivqlsgt 56 4 the the DT cord-345211-4ivqlsgt 56 5 diagnosis diagnosis NN cord-345211-4ivqlsgt 56 6 of of IN cord-345211-4ivqlsgt 56 7 viral viral JJ cord-345211-4ivqlsgt 56 8 respiratory respiratory JJ cord-345211-4ivqlsgt 56 9 tract tract NN cord-345211-4ivqlsgt 56 10 infections infection NNS cord-345211-4ivqlsgt 56 11 [ [ -LRB- cord-345211-4ivqlsgt 56 12 19 19 CD cord-345211-4ivqlsgt 56 13 , , , cord-345211-4ivqlsgt 56 14 20 20 CD cord-345211-4ivqlsgt 56 15 ] ] -RRB- cord-345211-4ivqlsgt 56 16 . . . cord-345211-4ivqlsgt 57 1 With with IN cord-345211-4ivqlsgt 57 2 high high JJ cord-345211-4ivqlsgt 57 3 sensitivity sensitivity NN cord-345211-4ivqlsgt 57 4 and and CC cord-345211-4ivqlsgt 57 5 specificity specificity NN cord-345211-4ivqlsgt 57 6 , , , cord-345211-4ivqlsgt 57 7 rapid rapid JJ cord-345211-4ivqlsgt 57 8 turnaround turnaround NN cord-345211-4ivqlsgt 57 9 time time NN cord-345211-4ivqlsgt 57 10 , , , cord-345211-4ivqlsgt 57 11 and and CC cord-345211-4ivqlsgt 57 12 availability availability NN cord-345211-4ivqlsgt 57 13 as as IN cord-345211-4ivqlsgt 57 14 commercial commercial JJ cord-345211-4ivqlsgt 57 15 assays assay NNS cord-345211-4ivqlsgt 57 16 , , , cord-345211-4ivqlsgt 57 17 NATs NATs NNP cord-345211-4ivqlsgt 57 18 are be VBP cord-345211-4ivqlsgt 57 19 now now RB cord-345211-4ivqlsgt 57 20 the the DT cord-345211-4ivqlsgt 57 21 testing testing NN cord-345211-4ivqlsgt 57 22 method method NN cord-345211-4ivqlsgt 57 23 of of IN cord-345211-4ivqlsgt 57 24 choice choice NN cord-345211-4ivqlsgt 57 25 for for IN cord-345211-4ivqlsgt 57 26 respiratory respiratory JJ cord-345211-4ivqlsgt 57 27 viruses virus NNS cord-345211-4ivqlsgt 57 28 . . . cord-345211-4ivqlsgt 58 1 Respiratory respiratory JJ cord-345211-4ivqlsgt 58 2 viruses virus NNS cord-345211-4ivqlsgt 58 3 commonly commonly RB cord-345211-4ivqlsgt 58 4 detected detect VBN cord-345211-4ivqlsgt 58 5 by by IN cord-345211-4ivqlsgt 58 6 NATs NATs NNP cord-345211-4ivqlsgt 58 7 , , , cord-345211-4ivqlsgt 58 8 often often RB cord-345211-4ivqlsgt 58 9 in in IN cord-345211-4ivqlsgt 58 10 large large JJ cord-345211-4ivqlsgt 58 11 multiplex multiplex JJ cord-345211-4ivqlsgt 58 12 panels panel NNS cord-345211-4ivqlsgt 58 13 , , , cord-345211-4ivqlsgt 58 14 include include VBP cord-345211-4ivqlsgt 58 15 influenza influenza NN cord-345211-4ivqlsgt 58 16 A a NN cord-345211-4ivqlsgt 58 17 and and CC cord-345211-4ivqlsgt 58 18 B b NN cord-345211-4ivqlsgt 58 19 viruses virus NNS cord-345211-4ivqlsgt 58 20 , , , cord-345211-4ivqlsgt 58 21 respiratory respiratory JJ cord-345211-4ivqlsgt 58 22 syncytial syncytial JJ cord-345211-4ivqlsgt 58 23 virus virus NN cord-345211-4ivqlsgt 58 24 , , , cord-345211-4ivqlsgt 58 25 parainfluenza parainfluenza NNP cord-345211-4ivqlsgt 58 26 viruses virus NNS cord-345211-4ivqlsgt 58 27 , , , cord-345211-4ivqlsgt 58 28 human human JJ cord-345211-4ivqlsgt 58 29 metapneumovirus metapneumovirus NNP cord-345211-4ivqlsgt 58 30 , , , cord-345211-4ivqlsgt 58 31 human human JJ cord-345211-4ivqlsgt 58 32 rhinoviruses rhinovirus NNS cord-345211-4ivqlsgt 58 33 , , , cord-345211-4ivqlsgt 58 34 enteroviruses enterovirus NNS cord-345211-4ivqlsgt 58 35 , , , cord-345211-4ivqlsgt 58 36 adenoviruses adenovirus NNS cord-345211-4ivqlsgt 58 37 , , , cord-345211-4ivqlsgt 58 38 human human JJ cord-345211-4ivqlsgt 58 39 bocavirus bocavirus NN cord-345211-4ivqlsgt 58 40 , , , cord-345211-4ivqlsgt 58 41 and and CC cord-345211-4ivqlsgt 58 42 several several JJ cord-345211-4ivqlsgt 58 43 coronaviruses coronaviruse NNS cord-345211-4ivqlsgt 58 44 ( ( -LRB- cord-345211-4ivqlsgt 58 45 OC43 OC43 NNP cord-345211-4ivqlsgt 58 46 , , , cord-345211-4ivqlsgt 58 47 229E 229e CD cord-345211-4ivqlsgt 58 48 , , , cord-345211-4ivqlsgt 58 49 NL63 NL63 NNP cord-345211-4ivqlsgt 58 50 , , , cord-345211-4ivqlsgt 58 51 and and CC cord-345211-4ivqlsgt 58 52 HKU1 HKU1 NNP cord-345211-4ivqlsgt 58 53 ) ) -RRB- cord-345211-4ivqlsgt 58 54 . . . cord-345211-4ivqlsgt 59 1 NATs NATs NNP cord-345211-4ivqlsgt 59 2 are be VBP cord-345211-4ivqlsgt 59 3 also also RB cord-345211-4ivqlsgt 59 4 established establish VBN cord-345211-4ivqlsgt 59 5 diagnostic diagnostic JJ cord-345211-4ivqlsgt 59 6 tools tool NNS cord-345211-4ivqlsgt 59 7 for for IN cord-345211-4ivqlsgt 59 8 detection detection NN cord-345211-4ivqlsgt 59 9 of of IN cord-345211-4ivqlsgt 59 10 severe severe JJ cord-345211-4ivqlsgt 59 11 acute acute JJ cord-345211-4ivqlsgt 59 12 respiratory respiratory JJ cord-345211-4ivqlsgt 59 13 syndromecoronavirus syndromecoronavirus NN cord-345211-4ivqlsgt 59 14 and and CC cord-345211-4ivqlsgt 59 15 MERS MERS NNP cord-345211-4ivqlsgt 59 16 - - HYPH cord-345211-4ivqlsgt 59 17 coronavirus coronavirus NN cord-345211-4ivqlsgt 59 18 [ [ -LRB- cord-345211-4ivqlsgt 59 19 16 16 CD cord-345211-4ivqlsgt 59 20 , , , cord-345211-4ivqlsgt 59 21 20 20 CD cord-345211-4ivqlsgt 59 22 ] ] -RRB- cord-345211-4ivqlsgt 59 23 . . . cord-345211-4ivqlsgt 60 1 In in IN cord-345211-4ivqlsgt 60 2 the the DT cord-345211-4ivqlsgt 60 3 context context NN cord-345211-4ivqlsgt 60 4 of of IN cord-345211-4ivqlsgt 60 5 pneumonia pneumonia NN cord-345211-4ivqlsgt 60 6 , , , cord-345211-4ivqlsgt 60 7 the the DT cord-345211-4ivqlsgt 60 8 detection detection NN cord-345211-4ivqlsgt 60 9 of of IN cord-345211-4ivqlsgt 60 10 a a DT cord-345211-4ivqlsgt 60 11 respiratory respiratory JJ cord-345211-4ivqlsgt 60 12 virus virus NN cord-345211-4ivqlsgt 60 13 in in IN cord-345211-4ivqlsgt 60 14 an an DT cord-345211-4ivqlsgt 60 15 upper upper JJ cord-345211-4ivqlsgt 60 16 respiratory respiratory JJ cord-345211-4ivqlsgt 60 17 specimen specimen NN cord-345211-4ivqlsgt 60 18 by by IN cord-345211-4ivqlsgt 60 19 a a DT cord-345211-4ivqlsgt 60 20 NAT NAT NNP cord-345211-4ivqlsgt 60 21 has have VBZ cord-345211-4ivqlsgt 60 22 been be VBN cord-345211-4ivqlsgt 60 23 regarded regard VBN cord-345211-4ivqlsgt 60 24 as as IN cord-345211-4ivqlsgt 60 25 sufficient sufficient JJ cord-345211-4ivqlsgt 60 26 to to TO cord-345211-4ivqlsgt 60 27 assign assign VB cord-345211-4ivqlsgt 60 28 causation causation NN cord-345211-4ivqlsgt 60 29 in in IN cord-345211-4ivqlsgt 60 30 both both DT cord-345211-4ivqlsgt 60 31 children child NNS cord-345211-4ivqlsgt 60 32 and and CC cord-345211-4ivqlsgt 60 33 adults adult NNS cord-345211-4ivqlsgt 60 34 [ [ -LRB- cord-345211-4ivqlsgt 60 35 21 21 CD cord-345211-4ivqlsgt 60 36 ] ] -RRB- cord-345211-4ivqlsgt 60 37 . . . cord-345211-4ivqlsgt 61 1 However however RB cord-345211-4ivqlsgt 61 2 , , , cord-345211-4ivqlsgt 61 3 this this DT cord-345211-4ivqlsgt 61 4 assumption assumption NN cord-345211-4ivqlsgt 61 5 is be VBZ cord-345211-4ivqlsgt 61 6 not not RB cord-345211-4ivqlsgt 61 7 always always RB cord-345211-4ivqlsgt 61 8 reliable reliable JJ cord-345211-4ivqlsgt 61 9 . . . cord-345211-4ivqlsgt 62 1 There there EX cord-345211-4ivqlsgt 62 2 is be VBZ cord-345211-4ivqlsgt 62 3 still still RB cord-345211-4ivqlsgt 62 4 debate debate NN cord-345211-4ivqlsgt 62 5 about about IN cord-345211-4ivqlsgt 62 6 the the DT cord-345211-4ivqlsgt 62 7 exact exact JJ cord-345211-4ivqlsgt 62 8 role role NN cord-345211-4ivqlsgt 62 9 ( ( -LRB- cord-345211-4ivqlsgt 62 10 if if IN cord-345211-4ivqlsgt 62 11 any any DT cord-345211-4ivqlsgt 62 12 ) ) -RRB- cord-345211-4ivqlsgt 62 13 of of IN cord-345211-4ivqlsgt 62 14 some some DT cord-345211-4ivqlsgt 62 15 viruses virus NNS cord-345211-4ivqlsgt 62 16 in in IN cord-345211-4ivqlsgt 62 17 the the DT cord-345211-4ivqlsgt 62 18 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 62 19 of of IN cord-345211-4ivqlsgt 62 20 pneumonia pneumonia NN cord-345211-4ivqlsgt 62 21 , , , cord-345211-4ivqlsgt 62 22 including include VBG cord-345211-4ivqlsgt 62 23 human human JJ cord-345211-4ivqlsgt 62 24 rhinoviruses rhinovirus NNS cord-345211-4ivqlsgt 62 25 and and CC cord-345211-4ivqlsgt 62 26 human human JJ cord-345211-4ivqlsgt 62 27 bocavirus bocavirus NN cord-345211-4ivqlsgt 62 28 [ [ -LRB- cord-345211-4ivqlsgt 62 29 22 22 CD cord-345211-4ivqlsgt 62 30 ] ] -RRB- cord-345211-4ivqlsgt 62 31 . . . cord-345211-4ivqlsgt 63 1 This this DT cord-345211-4ivqlsgt 63 2 has have VBZ cord-345211-4ivqlsgt 63 3 led lead VBN cord-345211-4ivqlsgt 63 4 some some DT cord-345211-4ivqlsgt 63 5 to to TO cord-345211-4ivqlsgt 63 6 question question VB cord-345211-4ivqlsgt 63 7 the the DT cord-345211-4ivqlsgt 63 8 wisdom wisdom NN cord-345211-4ivqlsgt 63 9 of of IN cord-345211-4ivqlsgt 63 10 using use VBG cord-345211-4ivqlsgt 63 11 large large JJ cord-345211-4ivqlsgt 63 12 multiplex multiplex JJ cord-345211-4ivqlsgt 63 13 NAT NAT NNP cord-345211-4ivqlsgt 63 14 panels panel NNS cord-345211-4ivqlsgt 63 15 as as IN cord-345211-4ivqlsgt 63 16 first first JJ cord-345211-4ivqlsgt 63 17 - - HYPH cord-345211-4ivqlsgt 63 18 line line NN cord-345211-4ivqlsgt 63 19 tests test NNS cord-345211-4ivqlsgt 63 20 for for IN cord-345211-4ivqlsgt 63 21 respiratory respiratory JJ cord-345211-4ivqlsgt 63 22 pathogens pathogen NNS cord-345211-4ivqlsgt 63 23 given give VBN cord-345211-4ivqlsgt 63 24 potential potential JJ cord-345211-4ivqlsgt 63 25 problems problem NNS cord-345211-4ivqlsgt 63 26 with with IN cord-345211-4ivqlsgt 63 27 interpretation interpretation NN cord-345211-4ivqlsgt 63 28 of of IN cord-345211-4ivqlsgt 63 29 positive positive JJ cord-345211-4ivqlsgt 63 30 results result NNS cord-345211-4ivqlsgt 63 31 [ [ -LRB- cord-345211-4ivqlsgt 63 32 23 23 CD cord-345211-4ivqlsgt 63 33 ] ] -RRB- cord-345211-4ivqlsgt 63 34 . . . cord-345211-4ivqlsgt 64 1 In in IN cord-345211-4ivqlsgt 64 2 addition addition NN cord-345211-4ivqlsgt 64 3 , , , cord-345211-4ivqlsgt 64 4 when when WRB cord-345211-4ivqlsgt 64 5 control control NN cord-345211-4ivqlsgt 64 6 groups group NNS cord-345211-4ivqlsgt 64 7 are be VBP cord-345211-4ivqlsgt 64 8 used use VBN cord-345211-4ivqlsgt 64 9 in in IN cord-345211-4ivqlsgt 64 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 64 11 etiology etiology NN cord-345211-4ivqlsgt 64 12 studies study NNS cord-345211-4ivqlsgt 64 13 , , , cord-345211-4ivqlsgt 64 14 respiratory respiratory JJ cord-345211-4ivqlsgt 64 15 viruses virus NNS cord-345211-4ivqlsgt 64 16 are be VBP cord-345211-4ivqlsgt 64 17 often often RB cord-345211-4ivqlsgt 64 18 detected detect VBN cord-345211-4ivqlsgt 64 19 in in IN cord-345211-4ivqlsgt 64 20 a a DT cord-345211-4ivqlsgt 64 21 similar similar JJ cord-345211-4ivqlsgt 64 22 proportion proportion NN cord-345211-4ivqlsgt 64 23 of of IN cord-345211-4ivqlsgt 64 24 both both DT cord-345211-4ivqlsgt 64 25 subjects subject NNS cord-345211-4ivqlsgt 64 26 with with IN cord-345211-4ivqlsgt 64 27 and and CC cord-345211-4ivqlsgt 64 28 without without IN cord-345211-4ivqlsgt 64 29 pneumonia pneumonia NN cord-345211-4ivqlsgt 64 30 , , , cord-345211-4ivqlsgt 64 31 especially especially RB cord-345211-4ivqlsgt 64 32 in in IN cord-345211-4ivqlsgt 64 33 children child NNS cord-345211-4ivqlsgt 64 34 [ [ -LRB- cord-345211-4ivqlsgt 64 35 24 24 CD cord-345211-4ivqlsgt 64 36 , , , cord-345211-4ivqlsgt 64 37 25 25 CD cord-345211-4ivqlsgt 64 38 ] ] -RRB- cord-345211-4ivqlsgt 64 39 . . . cord-345211-4ivqlsgt 65 1 These these DT cord-345211-4ivqlsgt 65 2 findings finding NNS cord-345211-4ivqlsgt 65 3 vary vary VBP cord-345211-4ivqlsgt 65 4 by by IN cord-345211-4ivqlsgt 65 5 specific specific JJ cord-345211-4ivqlsgt 65 6 virus virus NN cord-345211-4ivqlsgt 65 7 , , , cord-345211-4ivqlsgt 65 8 with with IN cord-345211-4ivqlsgt 65 9 influenza influenza NN cord-345211-4ivqlsgt 65 10 A a NN cord-345211-4ivqlsgt 65 11 and and CC cord-345211-4ivqlsgt 65 12 B b NN cord-345211-4ivqlsgt 65 13 viruses virus NNS cord-345211-4ivqlsgt 65 14 , , , cord-345211-4ivqlsgt 65 15 respiratory respiratory JJ cord-345211-4ivqlsgt 65 16 syncytial syncytial JJ cord-345211-4ivqlsgt 65 17 virus virus NN cord-345211-4ivqlsgt 65 18 , , , cord-345211-4ivqlsgt 65 19 and and CC cord-345211-4ivqlsgt 65 20 human human NN cord-345211-4ivqlsgt 65 21 metapneumovirus metapneumovirus NN cord-345211-4ivqlsgt 65 22 being be VBG cord-345211-4ivqlsgt 65 23 typically typically RB cord-345211-4ivqlsgt 65 24 detected detect VBN cord-345211-4ivqlsgt 65 25 in in IN cord-345211-4ivqlsgt 65 26 a a DT cord-345211-4ivqlsgt 65 27 significantly significantly RB cord-345211-4ivqlsgt 65 28 higher high JJR cord-345211-4ivqlsgt 65 29 proportion proportion NN cord-345211-4ivqlsgt 65 30 of of IN cord-345211-4ivqlsgt 65 31 cases case NNS cord-345211-4ivqlsgt 65 32 with with IN cord-345211-4ivqlsgt 65 33 pneumonia pneumonia NN cord-345211-4ivqlsgt 65 34 than than IN cord-345211-4ivqlsgt 65 35 controls control NNS cord-345211-4ivqlsgt 65 36 . . . cord-345211-4ivqlsgt 66 1 Environmental environmental JJ cord-345211-4ivqlsgt 66 2 bacteria bacteria NNS cord-345211-4ivqlsgt 66 3 of of IN cord-345211-4ivqlsgt 66 4 the the DT cord-345211-4ivqlsgt 66 5 genus genus NN cord-345211-4ivqlsgt 66 6 Legionella Legionella NNP cord-345211-4ivqlsgt 66 7 are be VBP cord-345211-4ivqlsgt 66 8 the the DT cord-345211-4ivqlsgt 66 9 cause cause NN cord-345211-4ivqlsgt 66 10 of of IN cord-345211-4ivqlsgt 66 11 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 66 12 ' ' POS cord-345211-4ivqlsgt 66 13 disease disease NN cord-345211-4ivqlsgt 66 14 , , , cord-345211-4ivqlsgt 66 15 a a DT cord-345211-4ivqlsgt 66 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 66 17 that that WDT cord-345211-4ivqlsgt 66 18 requires require VBZ cord-345211-4ivqlsgt 66 19 specific specific JJ cord-345211-4ivqlsgt 66 20 antimicrobial antimicrobial JJ cord-345211-4ivqlsgt 66 21 treatment treatment NN cord-345211-4ivqlsgt 66 22 and and CC cord-345211-4ivqlsgt 66 23 is be VBZ cord-345211-4ivqlsgt 66 24 often often RB cord-345211-4ivqlsgt 66 25 associated associate VBN cord-345211-4ivqlsgt 66 26 with with IN cord-345211-4ivqlsgt 66 27 outbreaks outbreak NNS cord-345211-4ivqlsgt 66 28 [ [ -LRB- cord-345211-4ivqlsgt 66 29 26 26 CD cord-345211-4ivqlsgt 66 30 ] ] -RRB- cord-345211-4ivqlsgt 66 31 . . . cord-345211-4ivqlsgt 67 1 Of of IN cord-345211-4ivqlsgt 67 2 the the DT cord-345211-4ivqlsgt 67 3 many many JJ cord-345211-4ivqlsgt 67 4 Legionella Legionella NNP cord-345211-4ivqlsgt 67 5 species specie NNS cord-345211-4ivqlsgt 67 6 that that WDT cord-345211-4ivqlsgt 67 7 can can MD cord-345211-4ivqlsgt 67 8 cause cause VB cord-345211-4ivqlsgt 67 9 human human JJ cord-345211-4ivqlsgt 67 10 infection infection NN cord-345211-4ivqlsgt 67 11 , , , cord-345211-4ivqlsgt 67 12 Legionella Legionella NNP cord-345211-4ivqlsgt 67 13 pneumophila pneumophila NN cord-345211-4ivqlsgt 67 14 is be VBZ cord-345211-4ivqlsgt 67 15 the the DT cord-345211-4ivqlsgt 67 16 most most RBS cord-345211-4ivqlsgt 67 17 common common JJ cord-345211-4ivqlsgt 67 18 cause cause NN cord-345211-4ivqlsgt 67 19 globally globally RB cord-345211-4ivqlsgt 67 20 , , , cord-345211-4ivqlsgt 67 21 with with IN cord-345211-4ivqlsgt 67 22 infection infection NN cord-345211-4ivqlsgt 67 23 usually usually RB cord-345211-4ivqlsgt 67 24 acquired acquire VBN cord-345211-4ivqlsgt 67 25 from from IN cord-345211-4ivqlsgt 67 26 water water NN cord-345211-4ivqlsgt 67 27 sources source NNS cord-345211-4ivqlsgt 67 28 . . . cord-345211-4ivqlsgt 68 1 Other other JJ cord-345211-4ivqlsgt 68 2 species specie NNS cord-345211-4ivqlsgt 68 3 predominate predominate VBP cord-345211-4ivqlsgt 68 4 in in IN cord-345211-4ivqlsgt 68 5 some some DT cord-345211-4ivqlsgt 68 6 geographic geographic JJ cord-345211-4ivqlsgt 68 7 locations location NNS cord-345211-4ivqlsgt 68 8 , , , cord-345211-4ivqlsgt 68 9 particularly particularly RB cord-345211-4ivqlsgt 68 10 Legionella Legionella NNP cord-345211-4ivqlsgt 68 11 longbeachae longbeachae NN cord-345211-4ivqlsgt 68 12 which which WDT cord-345211-4ivqlsgt 68 13 is be VBZ cord-345211-4ivqlsgt 68 14 an an DT cord-345211-4ivqlsgt 68 15 inhabitant inhabitant NN cord-345211-4ivqlsgt 68 16 of of IN cord-345211-4ivqlsgt 68 17 soil soil NN cord-345211-4ivqlsgt 68 18 and and CC cord-345211-4ivqlsgt 68 19 compost compost NN cord-345211-4ivqlsgt 68 20 . . . cord-345211-4ivqlsgt 69 1 There there EX cord-345211-4ivqlsgt 69 2 is be VBZ cord-345211-4ivqlsgt 69 3 no no DT cord-345211-4ivqlsgt 69 4 human human NN cord-345211-4ivqlsgt 69 5 - - HYPH cord-345211-4ivqlsgt 69 6 to to IN cord-345211-4ivqlsgt 69 7 - - HYPH cord-345211-4ivqlsgt 69 8 human human JJ cord-345211-4ivqlsgt 69 9 spread spread NN cord-345211-4ivqlsgt 69 10 of of IN cord-345211-4ivqlsgt 69 11 Legionnaires Legionnaires NNPS cord-345211-4ivqlsgt 69 12 ' ' POS cord-345211-4ivqlsgt 69 13 disease disease NN cord-345211-4ivqlsgt 69 14 , , , cord-345211-4ivqlsgt 69 15 and and CC cord-345211-4ivqlsgt 69 16 human human JJ cord-345211-4ivqlsgt 69 17 infection infection NN cord-345211-4ivqlsgt 69 18 follows follow VBZ cord-345211-4ivqlsgt 69 19 environmental environmental JJ cord-345211-4ivqlsgt 69 20 exposure exposure NN cord-345211-4ivqlsgt 69 21 to to IN cord-345211-4ivqlsgt 69 22 the the DT cord-345211-4ivqlsgt 69 23 causative causative JJ cord-345211-4ivqlsgt 69 24 microorganism microorganism NN cord-345211-4ivqlsgt 69 25 . . . cord-345211-4ivqlsgt 70 1 Legionella Legionella NNP cord-345211-4ivqlsgt 70 2 spp spp NNS cord-345211-4ivqlsgt 70 3 . . . cord-345211-4ivqlsgt 71 1 are be VBP cord-345211-4ivqlsgt 71 2 fastidious fastidious JJ cord-345211-4ivqlsgt 71 3 organisms organism NNS cord-345211-4ivqlsgt 71 4 and and CC cord-345211-4ivqlsgt 71 5 the the DT cord-345211-4ivqlsgt 71 6 traditional traditional JJ cord-345211-4ivqlsgt 71 7 reliance reliance NN cord-345211-4ivqlsgt 71 8 on on IN cord-345211-4ivqlsgt 71 9 culture culture NN cord-345211-4ivqlsgt 71 10 , , , cord-345211-4ivqlsgt 71 11 serology serology NN cord-345211-4ivqlsgt 71 12 , , , cord-345211-4ivqlsgt 71 13 and and CC cord-345211-4ivqlsgt 71 14 urinary urinary JJ cord-345211-4ivqlsgt 71 15 antigen antigen NN cord-345211-4ivqlsgt 71 16 tests test NNS cord-345211-4ivqlsgt 71 17 has have VBZ cord-345211-4ivqlsgt 71 18 led lead VBN cord-345211-4ivqlsgt 71 19 to to IN cord-345211-4ivqlsgt 71 20 underdiagnosis underdiagnosis NN cord-345211-4ivqlsgt 71 21 of of IN cord-345211-4ivqlsgt 71 22 Legionnaires Legionnaires NNPS cord-345211-4ivqlsgt 71 23 ' ' POS cord-345211-4ivqlsgt 71 24 disease disease NN cord-345211-4ivqlsgt 71 25 globally globally RB cord-345211-4ivqlsgt 71 26 [ [ -LRB- cord-345211-4ivqlsgt 71 27 27 27 CD cord-345211-4ivqlsgt 71 28 ] ] -RRB- cord-345211-4ivqlsgt 71 29 . . . cord-345211-4ivqlsgt 72 1 Indeed indeed RB cord-345211-4ivqlsgt 72 2 , , , cord-345211-4ivqlsgt 72 3 the the DT cord-345211-4ivqlsgt 72 4 almost almost RB cord-345211-4ivqlsgt 72 5 sole sole JJ cord-345211-4ivqlsgt 72 6 reliance reliance NN cord-345211-4ivqlsgt 72 7 on on IN cord-345211-4ivqlsgt 72 8 the the DT cord-345211-4ivqlsgt 72 9 urinary urinary JJ cord-345211-4ivqlsgt 72 10 antigen antigen NN cord-345211-4ivqlsgt 72 11 test test NN cord-345211-4ivqlsgt 72 12 , , , cord-345211-4ivqlsgt 72 13 which which WDT cord-345211-4ivqlsgt 72 14 can can MD cord-345211-4ivqlsgt 72 15 only only RB cord-345211-4ivqlsgt 72 16 detect detect VB cord-345211-4ivqlsgt 72 17 L. L. NNP cord-345211-4ivqlsgt 72 18 pneumophila pneumophila NN cord-345211-4ivqlsgt 72 19 serogroup serogroup NNP cord-345211-4ivqlsgt 72 20 1 1 CD cord-345211-4ivqlsgt 72 21 , , , cord-345211-4ivqlsgt 72 22 in in IN cord-345211-4ivqlsgt 72 23 some some DT cord-345211-4ivqlsgt 72 24 parts part NNS cord-345211-4ivqlsgt 72 25 of of IN cord-345211-4ivqlsgt 72 26 the the DT cord-345211-4ivqlsgt 72 27 world world NN cord-345211-4ivqlsgt 72 28 has have VBZ cord-345211-4ivqlsgt 72 29 created create VBN cord-345211-4ivqlsgt 72 30 a a DT cord-345211-4ivqlsgt 72 31 ' ' `` cord-345211-4ivqlsgt 72 32 blind blind JJ cord-345211-4ivqlsgt 72 33 spot spot NN cord-345211-4ivqlsgt 72 34 ' ' '' cord-345211-4ivqlsgt 72 35 for for IN cord-345211-4ivqlsgt 72 36 Legionnaires Legionnaires NNPS cord-345211-4ivqlsgt 72 37 ' ' POS cord-345211-4ivqlsgt 72 38 disease disease NN cord-345211-4ivqlsgt 72 39 caused cause VBN cord-345211-4ivqlsgt 72 40 by by IN cord-345211-4ivqlsgt 72 41 other other JJ cord-345211-4ivqlsgt 72 42 species specie NNS cord-345211-4ivqlsgt 72 43 and and CC cord-345211-4ivqlsgt 72 44 serogroups serogroup NNS cord-345211-4ivqlsgt 72 45 [ [ -LRB- cord-345211-4ivqlsgt 72 46 27 27 CD cord-345211-4ivqlsgt 72 47 ] ] -RRB- cord-345211-4ivqlsgt 72 48 . . . cord-345211-4ivqlsgt 73 1 NATs NATs NNP cord-345211-4ivqlsgt 73 2 have have VBP cord-345211-4ivqlsgt 73 3 long long RB cord-345211-4ivqlsgt 73 4 been be VBN cord-345211-4ivqlsgt 73 5 used use VBN cord-345211-4ivqlsgt 73 6 to to TO cord-345211-4ivqlsgt 73 7 detect detect VB cord-345211-4ivqlsgt 73 8 Legionella legionella NN cord-345211-4ivqlsgt 73 9 infection infection NN cord-345211-4ivqlsgt 73 10 [ [ -LRB- cord-345211-4ivqlsgt 73 11 27 27 CD cord-345211-4ivqlsgt 73 12 ] ] -RRB- cord-345211-4ivqlsgt 73 13 and and CC cord-345211-4ivqlsgt 73 14 are be VBP cord-345211-4ivqlsgt 73 15 well well RB cord-345211-4ivqlsgt 73 16 - - HYPH cord-345211-4ivqlsgt 73 17 suited suit VBN cord-345211-4ivqlsgt 73 18 for for IN cord-345211-4ivqlsgt 73 19 this this DT cord-345211-4ivqlsgt 73 20 purpose purpose NN cord-345211-4ivqlsgt 73 21 . . . cord-345211-4ivqlsgt 74 1 Legionella legionella NN cord-345211-4ivqlsgt 74 2 are be VBP cord-345211-4ivqlsgt 74 3 not not RB cord-345211-4ivqlsgt 74 4 regarded regard VBN cord-345211-4ivqlsgt 74 5 as as IN cord-345211-4ivqlsgt 74 6 human human JJ cord-345211-4ivqlsgt 74 7 colonizers colonizer NNS cord-345211-4ivqlsgt 74 8 [ [ -LRB- cord-345211-4ivqlsgt 74 9 28 28 CD cord-345211-4ivqlsgt 74 10 ] ] -RRB- cord-345211-4ivqlsgt 74 11 , , , cord-345211-4ivqlsgt 74 12 and and CC cord-345211-4ivqlsgt 74 13 the the DT cord-345211-4ivqlsgt 74 14 detection detection NN cord-345211-4ivqlsgt 74 15 of of IN cord-345211-4ivqlsgt 74 16 any any DT cord-345211-4ivqlsgt 74 17 amount amount NN cord-345211-4ivqlsgt 74 18 of of IN cord-345211-4ivqlsgt 74 19 legionellae legionellae NNS cord-345211-4ivqlsgt 74 20 in in IN cord-345211-4ivqlsgt 74 21 a a DT cord-345211-4ivqlsgt 74 22 clinical clinical JJ cord-345211-4ivqlsgt 74 23 specimen specimen NN cord-345211-4ivqlsgt 74 24 is be VBZ cord-345211-4ivqlsgt 74 25 regarded regard VBN cord-345211-4ivqlsgt 74 26 as as RB cord-345211-4ivqlsgt 74 27 diagnostic diagnostic JJ cord-345211-4ivqlsgt 74 28 for for IN cord-345211-4ivqlsgt 74 29 infection infection NN cord-345211-4ivqlsgt 74 30 , , , cord-345211-4ivqlsgt 74 31 assuming assume VBG cord-345211-4ivqlsgt 74 32 contamination contamination NN cord-345211-4ivqlsgt 74 33 has have VBZ cord-345211-4ivqlsgt 74 34 not not RB cord-345211-4ivqlsgt 74 35 occurred occur VBN cord-345211-4ivqlsgt 74 36 during during IN cord-345211-4ivqlsgt 74 37 the the DT cord-345211-4ivqlsgt 74 38 testing testing NN cord-345211-4ivqlsgt 74 39 process process NN cord-345211-4ivqlsgt 74 40 . . . cord-345211-4ivqlsgt 75 1 Furthermore furthermore RB cord-345211-4ivqlsgt 75 2 , , , cord-345211-4ivqlsgt 75 3 all all DT cord-345211-4ivqlsgt 75 4 species specie NNS cord-345211-4ivqlsgt 75 5 and and CC cord-345211-4ivqlsgt 75 6 serogroups serogroup NNS cord-345211-4ivqlsgt 75 7 can can MD cord-345211-4ivqlsgt 75 8 be be VB cord-345211-4ivqlsgt 75 9 detected detect VBN cord-345211-4ivqlsgt 75 10 . . . cord-345211-4ivqlsgt 76 1 Legionella Legionella NNP cord-345211-4ivqlsgt 76 2 DNA DNA NNP cord-345211-4ivqlsgt 76 3 has have VBZ cord-345211-4ivqlsgt 76 4 been be VBN cord-345211-4ivqlsgt 76 5 detected detect VBN cord-345211-4ivqlsgt 76 6 in in IN cord-345211-4ivqlsgt 76 7 both both CC cord-345211-4ivqlsgt 76 8 upper upper JJ cord-345211-4ivqlsgt 76 9 and and CC cord-345211-4ivqlsgt 76 10 lower low JJR cord-345211-4ivqlsgt 76 11 respiratory respiratory JJ cord-345211-4ivqlsgt 76 12 samples sample NNS cord-345211-4ivqlsgt 76 13 , , , cord-345211-4ivqlsgt 76 14 urine urine NN cord-345211-4ivqlsgt 76 15 , , , cord-345211-4ivqlsgt 76 16 and and CC cord-345211-4ivqlsgt 76 17 blood blood NN cord-345211-4ivqlsgt 76 18 from from IN cord-345211-4ivqlsgt 76 19 patients patient NNS cord-345211-4ivqlsgt 76 20 with with IN cord-345211-4ivqlsgt 76 21 Legionnaires Legionnaires NNPS cord-345211-4ivqlsgt 76 22 ' ' POS cord-345211-4ivqlsgt 76 23 disease disease NN cord-345211-4ivqlsgt 76 24 [ [ -LRB- cord-345211-4ivqlsgt 76 25 29 29 CD cord-345211-4ivqlsgt 76 26 ] ] -RRB- cord-345211-4ivqlsgt 76 27 [ [ -LRB- cord-345211-4ivqlsgt 76 28 30 30 CD cord-345211-4ivqlsgt 76 29 ] ] -RRB- cord-345211-4ivqlsgt 76 30 [ [ -LRB- cord-345211-4ivqlsgt 76 31 31 31 CD cord-345211-4ivqlsgt 76 32 ] ] -RRB- cord-345211-4ivqlsgt 77 1 [ [ -LRB- cord-345211-4ivqlsgt 77 2 32 32 CD cord-345211-4ivqlsgt 77 3 ] ] -RRB- cord-345211-4ivqlsgt 77 4 [ [ -LRB- cord-345211-4ivqlsgt 77 5 33 33 CD cord-345211-4ivqlsgt 77 6 ] ] -RRB- cord-345211-4ivqlsgt 77 7 [ [ -LRB- cord-345211-4ivqlsgt 77 8 34 34 CD cord-345211-4ivqlsgt 77 9 ] ] -RRB- cord-345211-4ivqlsgt 77 10 , , , cord-345211-4ivqlsgt 77 11 although although IN cord-345211-4ivqlsgt 77 12 sputum sputum NN cord-345211-4ivqlsgt 77 13 and and CC cord-345211-4ivqlsgt 77 14 other other JJ cord-345211-4ivqlsgt 77 15 lower low JJR cord-345211-4ivqlsgt 77 16 respiratory respiratory JJ cord-345211-4ivqlsgt 77 17 samples sample NNS cord-345211-4ivqlsgt 77 18 are be VBP cord-345211-4ivqlsgt 77 19 regarded regard VBN cord-345211-4ivqlsgt 77 20 as as IN cord-345211-4ivqlsgt 77 21 the the DT cord-345211-4ivqlsgt 77 22 specimens specimen NNS cord-345211-4ivqlsgt 77 23 of of IN cord-345211-4ivqlsgt 77 24 choice choice NN cord-345211-4ivqlsgt 77 25 [ [ -LRB- cord-345211-4ivqlsgt 77 26 31 31 CD cord-345211-4ivqlsgt 77 27 ] ] -RRB- cord-345211-4ivqlsgt 77 28 . . . cord-345211-4ivqlsgt 78 1 Recently recently RB cord-345211-4ivqlsgt 78 2 , , , cord-345211-4ivqlsgt 78 3 the the DT cord-345211-4ivqlsgt 78 4 systematic systematic JJ cord-345211-4ivqlsgt 78 5 use use NN cord-345211-4ivqlsgt 78 6 of of IN cord-345211-4ivqlsgt 78 7 PCR PCR NNP cord-345211-4ivqlsgt 78 8 [ [ -LRB- cord-345211-4ivqlsgt 78 9 31 31 CD cord-345211-4ivqlsgt 78 10 ] ] -RRB- cord-345211-4ivqlsgt 78 11 and and CC cord-345211-4ivqlsgt 78 12 collection collection NN cord-345211-4ivqlsgt 78 13 of of IN cord-345211-4ivqlsgt 78 14 induced induce VBN cord-345211-4ivqlsgt 78 15 sputum sputum NN cord-345211-4ivqlsgt 78 16 from from IN cord-345211-4ivqlsgt 78 17 patients patient NNS cord-345211-4ivqlsgt 78 18 unable unable JJ cord-345211-4ivqlsgt 78 19 to to TO cord-345211-4ivqlsgt 78 20 expectorate expectorate VB cord-345211-4ivqlsgt 78 21 [ [ -LRB- cord-345211-4ivqlsgt 78 22 35 35 CD cord-345211-4ivqlsgt 78 23 ] ] -RRB- cord-345211-4ivqlsgt 78 24 have have VBP cord-345211-4ivqlsgt 78 25 uncovered uncover VBN cord-345211-4ivqlsgt 78 26 a a DT cord-345211-4ivqlsgt 78 27 hidden hide VBN cord-345211-4ivqlsgt 78 28 burden burden NN cord-345211-4ivqlsgt 78 29 of of IN cord-345211-4ivqlsgt 78 30 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 78 31 ' ' POS cord-345211-4ivqlsgt 78 32 disease disease NN cord-345211-4ivqlsgt 78 33 and and CC cord-345211-4ivqlsgt 78 34 have have VBP cord-345211-4ivqlsgt 78 35 demonstrated demonstrate VBN cord-345211-4ivqlsgt 78 36 the the DT cord-345211-4ivqlsgt 78 37 diagnostic diagnostic JJ cord-345211-4ivqlsgt 78 38 utility utility NN cord-345211-4ivqlsgt 78 39 of of IN cord-345211-4ivqlsgt 78 40 NATs NATs NNP cord-345211-4ivqlsgt 78 41 for for IN cord-345211-4ivqlsgt 78 42 this this DT cord-345211-4ivqlsgt 78 43 disease disease NN cord-345211-4ivqlsgt 78 44 . . . cord-345211-4ivqlsgt 79 1 Arguably arguably RB cord-345211-4ivqlsgt 79 2 , , , cord-345211-4ivqlsgt 79 3 NATs NATs NNP cord-345211-4ivqlsgt 79 4 are be VBP cord-345211-4ivqlsgt 79 5 now now RB cord-345211-4ivqlsgt 79 6 the the DT cord-345211-4ivqlsgt 79 7 test test NN cord-345211-4ivqlsgt 79 8 of of IN cord-345211-4ivqlsgt 79 9 choice choice NN cord-345211-4ivqlsgt 79 10 for for IN cord-345211-4ivqlsgt 79 11 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 79 12 ' ' POS cord-345211-4ivqlsgt 79 13 disease disease NN cord-345211-4ivqlsgt 79 14 . . . cord-345211-4ivqlsgt 80 1 Being be VBG cord-345211-4ivqlsgt 80 2 an an DT cord-345211-4ivqlsgt 80 3 environmental environmental JJ cord-345211-4ivqlsgt 80 4 organism organism NN cord-345211-4ivqlsgt 80 5 , , , cord-345211-4ivqlsgt 80 6 there there EX cord-345211-4ivqlsgt 80 7 has have VBZ cord-345211-4ivqlsgt 80 8 been be VBN cord-345211-4ivqlsgt 80 9 concern concern NN cord-345211-4ivqlsgt 80 10 about about IN cord-345211-4ivqlsgt 80 11 Legionella legionella NN cord-345211-4ivqlsgt 80 12 contamination contamination NN cord-345211-4ivqlsgt 80 13 during during IN cord-345211-4ivqlsgt 80 14 testing testing NN cord-345211-4ivqlsgt 80 15 , , , cord-345211-4ivqlsgt 80 16 highlighted highlight VBN cord-345211-4ivqlsgt 80 17 by by IN cord-345211-4ivqlsgt 80 18 the the DT cord-345211-4ivqlsgt 80 19 occasional occasional JJ cord-345211-4ivqlsgt 80 20 documented document VBN cord-345211-4ivqlsgt 80 21 contamination contamination NN cord-345211-4ivqlsgt 80 22 of of IN cord-345211-4ivqlsgt 80 23 nucleic nucleic JJ cord-345211-4ivqlsgt 80 24 acid acid NN cord-345211-4ivqlsgt 80 25 extraction extraction NN cord-345211-4ivqlsgt 80 26 kits kit NNS cord-345211-4ivqlsgt 80 27 [ [ -LRB- cord-345211-4ivqlsgt 80 28 36 36 CD cord-345211-4ivqlsgt 80 29 ] ] -RRB- cord-345211-4ivqlsgt 80 30 . . . cord-345211-4ivqlsgt 81 1 This this DT cord-345211-4ivqlsgt 81 2 problem problem NN cord-345211-4ivqlsgt 81 3 can can MD cord-345211-4ivqlsgt 81 4 be be VB cord-345211-4ivqlsgt 81 5 overcome overcome VBN cord-345211-4ivqlsgt 81 6 by by IN cord-345211-4ivqlsgt 81 7 strict strict JJ cord-345211-4ivqlsgt 81 8 adherence adherence NN cord-345211-4ivqlsgt 81 9 to to IN cord-345211-4ivqlsgt 81 10 good good JJ cord-345211-4ivqlsgt 81 11 laboratory laboratory NN cord-345211-4ivqlsgt 81 12 practice practice NN cord-345211-4ivqlsgt 81 13 . . . cord-345211-4ivqlsgt 82 1 Mycoplasma mycoplasma NN cord-345211-4ivqlsgt 82 2 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 82 3 is be VBZ cord-345211-4ivqlsgt 82 4 associated associate VBN cord-345211-4ivqlsgt 82 5 with with IN cord-345211-4ivqlsgt 82 6 a a DT cord-345211-4ivqlsgt 82 7 variety variety NN cord-345211-4ivqlsgt 82 8 of of IN cord-345211-4ivqlsgt 82 9 both both CC cord-345211-4ivqlsgt 82 10 upper upper JJ cord-345211-4ivqlsgt 82 11 and and CC cord-345211-4ivqlsgt 82 12 lower low JJR cord-345211-4ivqlsgt 82 13 respiratory respiratory JJ cord-345211-4ivqlsgt 82 14 tract tract NN cord-345211-4ivqlsgt 82 15 infections infection NNS cord-345211-4ivqlsgt 82 16 and and CC cord-345211-4ivqlsgt 82 17 is be VBZ cord-345211-4ivqlsgt 82 18 an an DT cord-345211-4ivqlsgt 82 19 important important JJ cord-345211-4ivqlsgt 82 20 cause cause NN cord-345211-4ivqlsgt 82 21 of of IN cord-345211-4ivqlsgt 82 22 pneumonia pneumonia NN cord-345211-4ivqlsgt 82 23 , , , cord-345211-4ivqlsgt 82 24 frequently frequently RB cord-345211-4ivqlsgt 82 25 occurring occur VBG cord-345211-4ivqlsgt 82 26 in in IN cord-345211-4ivqlsgt 82 27 outbreaks outbreak NNS cord-345211-4ivqlsgt 82 28 . . . cord-345211-4ivqlsgt 83 1 NATs NATs NNP cord-345211-4ivqlsgt 83 2 are be VBP cord-345211-4ivqlsgt 83 3 now now RB cord-345211-4ivqlsgt 83 4 widely widely RB cord-345211-4ivqlsgt 83 5 regarded regard VBN cord-345211-4ivqlsgt 83 6 as as IN cord-345211-4ivqlsgt 83 7 the the DT cord-345211-4ivqlsgt 83 8 methods method NNS cord-345211-4ivqlsgt 83 9 of of IN cord-345211-4ivqlsgt 83 10 choice choice NN cord-345211-4ivqlsgt 83 11 for for IN cord-345211-4ivqlsgt 83 12 detection detection NN cord-345211-4ivqlsgt 83 13 of of IN cord-345211-4ivqlsgt 83 14 M. M. NNP cord-345211-4ivqlsgt 83 15 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 83 16 infections infection NNS cord-345211-4ivqlsgt 83 17 [ [ -LRB- cord-345211-4ivqlsgt 83 18 37 37 CD cord-345211-4ivqlsgt 83 19 , , , cord-345211-4ivqlsgt 83 20 38 38 CD cord-345211-4ivqlsgt 83 21 ] ] -RRB- cord-345211-4ivqlsgt 83 22 , , , cord-345211-4ivqlsgt 83 23 and and CC cord-345211-4ivqlsgt 83 24 a a DT cord-345211-4ivqlsgt 83 25 M. M. NNP cord-345211-4ivqlsgt 83 26 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 83 27 target target NN cord-345211-4ivqlsgt 83 28 has have VBZ cord-345211-4ivqlsgt 83 29 been be VBN cord-345211-4ivqlsgt 83 30 incorporated incorporate VBN cord-345211-4ivqlsgt 83 31 alongside alongside IN cord-345211-4ivqlsgt 83 32 viral viral JJ cord-345211-4ivqlsgt 83 33 targets target NNS cord-345211-4ivqlsgt 83 34 in in IN cord-345211-4ivqlsgt 83 35 many many JJ cord-345211-4ivqlsgt 83 36 large large JJ cord-345211-4ivqlsgt 83 37 respiratory respiratory JJ cord-345211-4ivqlsgt 83 38 multiplex multiplex NN cord-345211-4ivqlsgt 83 39 panels panel NNS cord-345211-4ivqlsgt 83 40 . . . cord-345211-4ivqlsgt 84 1 In in IN cord-345211-4ivqlsgt 84 2 practice practice NN cord-345211-4ivqlsgt 84 3 , , , cord-345211-4ivqlsgt 84 4 NATs nat NNS cord-345211-4ivqlsgt 84 5 have have VBP cord-345211-4ivqlsgt 84 6 also also RB cord-345211-4ivqlsgt 84 7 been be VBN cord-345211-4ivqlsgt 84 8 useful useful JJ cord-345211-4ivqlsgt 84 9 for for IN cord-345211-4ivqlsgt 84 10 M. M. NNP cord-345211-4ivqlsgt 84 11 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 84 12 outbreak outbreak NN cord-345211-4ivqlsgt 84 13 identification identification NN cord-345211-4ivqlsgt 84 14 and and CC cord-345211-4ivqlsgt 84 15 management management NN cord-345211-4ivqlsgt 84 16 [ [ -LRB- cord-345211-4ivqlsgt 84 17 39 39 CD cord-345211-4ivqlsgt 84 18 ] ] -RRB- cord-345211-4ivqlsgt 84 19 . . . cord-345211-4ivqlsgt 85 1 Both both DT cord-345211-4ivqlsgt 85 2 upper upper JJ cord-345211-4ivqlsgt 85 3 and and CC cord-345211-4ivqlsgt 85 4 lower low JJR cord-345211-4ivqlsgt 85 5 respiratory respiratory JJ cord-345211-4ivqlsgt 85 6 tract tract NN cord-345211-4ivqlsgt 85 7 specimens specimen NNS cord-345211-4ivqlsgt 85 8 are be VBP cord-345211-4ivqlsgt 85 9 suitable suitable JJ cord-345211-4ivqlsgt 85 10 for for IN cord-345211-4ivqlsgt 85 11 testing testing NN cord-345211-4ivqlsgt 85 12 by by IN cord-345211-4ivqlsgt 85 13 NATs NATs NNP cord-345211-4ivqlsgt 85 14 , , , cord-345211-4ivqlsgt 85 15 and and CC cord-345211-4ivqlsgt 85 16 a a DT cord-345211-4ivqlsgt 85 17 positive positive JJ cord-345211-4ivqlsgt 85 18 result result NN cord-345211-4ivqlsgt 85 19 in in IN cord-345211-4ivqlsgt 85 20 the the DT cord-345211-4ivqlsgt 85 21 context context NN cord-345211-4ivqlsgt 85 22 of of IN cord-345211-4ivqlsgt 85 23 pneumonia pneumonia NN cord-345211-4ivqlsgt 85 24 is be VBZ cord-345211-4ivqlsgt 85 25 regarded regard VBN cord-345211-4ivqlsgt 85 26 as as IN cord-345211-4ivqlsgt 85 27 being be VBG cord-345211-4ivqlsgt 85 28 diagnostic diagnostic JJ cord-345211-4ivqlsgt 85 29 , , , cord-345211-4ivqlsgt 85 30 as as IN cord-345211-4ivqlsgt 85 31 asymptomatic asymptomatic JJ cord-345211-4ivqlsgt 85 32 carriage carriage NN cord-345211-4ivqlsgt 85 33 of of IN cord-345211-4ivqlsgt 85 34 M. M. NNP cord-345211-4ivqlsgt 85 35 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 85 36 is be VBZ cord-345211-4ivqlsgt 85 37 uncommon uncommon JJ cord-345211-4ivqlsgt 85 38 [ [ -LRB- cord-345211-4ivqlsgt 85 39 40 40 CD cord-345211-4ivqlsgt 85 40 ] ] -RRB- cord-345211-4ivqlsgt 85 41 . . . cord-345211-4ivqlsgt 86 1 Chlamydophila chlamydophila NN cord-345211-4ivqlsgt 86 2 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 86 3 is be VBZ cord-345211-4ivqlsgt 86 4 a a DT cord-345211-4ivqlsgt 86 5 relatively relatively RB cord-345211-4ivqlsgt 86 6 common common JJ cord-345211-4ivqlsgt 86 7 cause cause NN cord-345211-4ivqlsgt 86 8 of of IN cord-345211-4ivqlsgt 86 9 community community NN cord-345211-4ivqlsgt 86 10 - - HYPH cord-345211-4ivqlsgt 86 11 acquired acquire VBN cord-345211-4ivqlsgt 86 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 86 13 in in IN cord-345211-4ivqlsgt 86 14 some some DT cord-345211-4ivqlsgt 86 15 geographic geographic JJ cord-345211-4ivqlsgt 86 16 regions region NNS cord-345211-4ivqlsgt 86 17 , , , cord-345211-4ivqlsgt 86 18 but but CC cord-345211-4ivqlsgt 86 19 is be VBZ cord-345211-4ivqlsgt 86 20 not not RB cord-345211-4ivqlsgt 86 21 typically typically RB cord-345211-4ivqlsgt 86 22 associated associate VBN cord-345211-4ivqlsgt 86 23 with with IN cord-345211-4ivqlsgt 86 24 severe severe JJ cord-345211-4ivqlsgt 86 25 disease disease NN cord-345211-4ivqlsgt 86 26 [ [ -LRB- cord-345211-4ivqlsgt 86 27 41 41 CD cord-345211-4ivqlsgt 86 28 , , , cord-345211-4ivqlsgt 86 29 42 42 CD cord-345211-4ivqlsgt 86 30 ] ] -RRB- cord-345211-4ivqlsgt 86 31 . . . cord-345211-4ivqlsgt 87 1 NATs NATs NNP cord-345211-4ivqlsgt 87 2 have have VBP cord-345211-4ivqlsgt 87 3 long long RB cord-345211-4ivqlsgt 87 4 been be VBN cord-345211-4ivqlsgt 87 5 used use VBN cord-345211-4ivqlsgt 87 6 for for IN cord-345211-4ivqlsgt 87 7 diagnostic diagnostic JJ cord-345211-4ivqlsgt 87 8 purposes purpose NNS cord-345211-4ivqlsgt 87 9 and and CC cord-345211-4ivqlsgt 87 10 , , , cord-345211-4ivqlsgt 87 11 indeed indeed RB cord-345211-4ivqlsgt 87 12 , , , cord-345211-4ivqlsgt 87 13 C. C. NNP cord-345211-4ivqlsgt 87 14 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 87 15 NATs NATs NNPS cord-345211-4ivqlsgt 87 16 were be VBD cord-345211-4ivqlsgt 87 17 the the DT cord-345211-4ivqlsgt 87 18 focus focus NN cord-345211-4ivqlsgt 87 19 of of IN cord-345211-4ivqlsgt 87 20 some some DT cord-345211-4ivqlsgt 87 21 of of IN cord-345211-4ivqlsgt 87 22 the the DT cord-345211-4ivqlsgt 87 23 earliest early JJS cord-345211-4ivqlsgt 87 24 efforts effort NNS cord-345211-4ivqlsgt 87 25 to to TO cord-345211-4ivqlsgt 87 26 standardize standardize VB cord-345211-4ivqlsgt 87 27 NATs nat NNS cord-345211-4ivqlsgt 87 28 for for IN cord-345211-4ivqlsgt 87 29 respiratory respiratory JJ cord-345211-4ivqlsgt 87 30 pathogens pathogen NNS cord-345211-4ivqlsgt 87 31 [ [ -LRB- cord-345211-4ivqlsgt 87 32 43 43 CD cord-345211-4ivqlsgt 87 33 ] ] -RRB- cord-345211-4ivqlsgt 87 34 . . . cord-345211-4ivqlsgt 88 1 Perhaps perhaps RB cord-345211-4ivqlsgt 88 2 because because IN cord-345211-4ivqlsgt 88 3 of of IN cord-345211-4ivqlsgt 88 4 the the DT cord-345211-4ivqlsgt 88 5 association association NN cord-345211-4ivqlsgt 88 6 with with IN cord-345211-4ivqlsgt 88 7 milder mild JJR cord-345211-4ivqlsgt 88 8 disease disease NN cord-345211-4ivqlsgt 88 9 , , , cord-345211-4ivqlsgt 88 10 C. C. NNP cord-345211-4ivqlsgt 88 11 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 88 12 targets target NNS cord-345211-4ivqlsgt 88 13 have have VBP cord-345211-4ivqlsgt 88 14 not not RB cord-345211-4ivqlsgt 88 15 been be VBN cord-345211-4ivqlsgt 88 16 a a DT cord-345211-4ivqlsgt 88 17 priority priority NN cord-345211-4ivqlsgt 88 18 for for IN cord-345211-4ivqlsgt 88 19 incorporation incorporation NN cord-345211-4ivqlsgt 88 20 into into IN cord-345211-4ivqlsgt 88 21 multiplex multiplex JJ cord-345211-4ivqlsgt 88 22 respiratory respiratory JJ cord-345211-4ivqlsgt 88 23 panels panel NNS cord-345211-4ivqlsgt 88 24 . . . cord-345211-4ivqlsgt 89 1 Colonization colonization NN cord-345211-4ivqlsgt 89 2 with with IN cord-345211-4ivqlsgt 89 3 Pneumocystis Pneumocystis NNP cord-345211-4ivqlsgt 89 4 jirovecii jirovecii NNP cord-345211-4ivqlsgt 89 5 is be VBZ cord-345211-4ivqlsgt 89 6 common common JJ cord-345211-4ivqlsgt 89 7 among among IN cord-345211-4ivqlsgt 89 8 the the DT cord-345211-4ivqlsgt 89 9 general general JJ cord-345211-4ivqlsgt 89 10 population population NN cord-345211-4ivqlsgt 89 11 and and CC cord-345211-4ivqlsgt 89 12 is be VBZ cord-345211-4ivqlsgt 89 13 associated associate VBN cord-345211-4ivqlsgt 89 14 with with IN cord-345211-4ivqlsgt 89 15 pneumonia pneumonia NN cord-345211-4ivqlsgt 89 16 in in IN cord-345211-4ivqlsgt 89 17 immunocompromised immunocompromised JJ cord-345211-4ivqlsgt 89 18 individuals individual NNS cord-345211-4ivqlsgt 89 19 . . . cord-345211-4ivqlsgt 90 1 NATs nat NNS cord-345211-4ivqlsgt 90 2 have have VBP cord-345211-4ivqlsgt 90 3 advantages advantage NNS cord-345211-4ivqlsgt 90 4 over over IN cord-345211-4ivqlsgt 90 5 traditional traditional JJ cord-345211-4ivqlsgt 90 6 microscopy microscopy NNS cord-345211-4ivqlsgt 90 7 - - HYPH cord-345211-4ivqlsgt 90 8 based base VBN cord-345211-4ivqlsgt 90 9 diagnostic diagnostic JJ cord-345211-4ivqlsgt 90 10 tools tool NNS cord-345211-4ivqlsgt 90 11 , , , cord-345211-4ivqlsgt 90 12 detecting detect VBG cord-345211-4ivqlsgt 90 13 P. P. NNP cord-345211-4ivqlsgt 90 14 jirovecii jirovecii NN cord-345211-4ivqlsgt 90 15 in in IN cord-345211-4ivqlsgt 90 16 induced induce VBN cord-345211-4ivqlsgt 90 17 sputum sputum NN cord-345211-4ivqlsgt 90 18 , , , cord-345211-4ivqlsgt 90 19 bronchoscopic bronchoscopic NNP cord-345211-4ivqlsgt 90 20 , , , cord-345211-4ivqlsgt 90 21 or or CC cord-345211-4ivqlsgt 90 22 oropharyngeal oropharyngeal JJ cord-345211-4ivqlsgt 90 23 specimens specimen NNS cord-345211-4ivqlsgt 90 24 with with IN cord-345211-4ivqlsgt 90 25 high high JJ cord-345211-4ivqlsgt 90 26 sensitivity sensitivity NN cord-345211-4ivqlsgt 90 27 [ [ -LRB- cord-345211-4ivqlsgt 90 28 44 44 CD cord-345211-4ivqlsgt 90 29 ] ] -RRB- cord-345211-4ivqlsgt 90 30 . . . cord-345211-4ivqlsgt 91 1 Indeed indeed RB cord-345211-4ivqlsgt 91 2 , , , cord-345211-4ivqlsgt 91 3 it -PRON- PRP cord-345211-4ivqlsgt 91 4 was be VBD cord-345211-4ivqlsgt 91 5 PCRbased pcrbase VBN cord-345211-4ivqlsgt 91 6 methods method NNS cord-345211-4ivqlsgt 91 7 that that WDT cord-345211-4ivqlsgt 91 8 provided provide VBD cord-345211-4ivqlsgt 91 9 some some DT cord-345211-4ivqlsgt 91 10 of of IN cord-345211-4ivqlsgt 91 11 the the DT cord-345211-4ivqlsgt 91 12 early early JJ cord-345211-4ivqlsgt 91 13 evidence evidence NN cord-345211-4ivqlsgt 91 14 of of IN cord-345211-4ivqlsgt 91 15 the the DT cord-345211-4ivqlsgt 91 16 existence existence NN cord-345211-4ivqlsgt 91 17 of of IN cord-345211-4ivqlsgt 91 18 P. P. NNP cord-345211-4ivqlsgt 91 19 jirovecii jirovecii NNP cord-345211-4ivqlsgt 91 20 colonization colonization NNP cord-345211-4ivqlsgt 91 21 [ [ -LRB- cord-345211-4ivqlsgt 91 22 45 45 CD cord-345211-4ivqlsgt 91 23 ] ] -RRB- cord-345211-4ivqlsgt 91 24 . . . cord-345211-4ivqlsgt 92 1 The the DT cord-345211-4ivqlsgt 92 2 use use NN cord-345211-4ivqlsgt 92 3 of of IN cord-345211-4ivqlsgt 92 4 quantitative quantitative JJ cord-345211-4ivqlsgt 92 5 methods method NNS cord-345211-4ivqlsgt 92 6 has have VBZ cord-345211-4ivqlsgt 92 7 been be VBN cord-345211-4ivqlsgt 92 8 necessary necessary JJ cord-345211-4ivqlsgt 92 9 in in IN cord-345211-4ivqlsgt 92 10 order order NN cord-345211-4ivqlsgt 92 11 to to TO cord-345211-4ivqlsgt 92 12 discriminate discriminate VB cord-345211-4ivqlsgt 92 13 between between IN cord-345211-4ivqlsgt 92 14 colonization colonization NN cord-345211-4ivqlsgt 92 15 and and CC cord-345211-4ivqlsgt 92 16 disease disease NN cord-345211-4ivqlsgt 92 17 ; ; : cord-345211-4ivqlsgt 92 18 thus thus RB cord-345211-4ivqlsgt 92 19 , , , cord-345211-4ivqlsgt 92 20 at at IN cord-345211-4ivqlsgt 92 21 least least JJS cord-345211-4ivqlsgt 92 22 partially partially RB cord-345211-4ivqlsgt 92 23 overcoming overcome VBG cord-345211-4ivqlsgt 92 24 the the DT cord-345211-4ivqlsgt 92 25 problem problem NN cord-345211-4ivqlsgt 92 26 of of IN cord-345211-4ivqlsgt 92 27 false false JJ cord-345211-4ivqlsgt 92 28 - - HYPH cord-345211-4ivqlsgt 92 29 positive positive JJ cord-345211-4ivqlsgt 92 30 results result NNS cord-345211-4ivqlsgt 92 31 . . . cord-345211-4ivqlsgt 93 1 Although although IN cord-345211-4ivqlsgt 93 2 promising promise VBG cord-345211-4ivqlsgt 93 3 , , , cord-345211-4ivqlsgt 93 4 the the DT cord-345211-4ivqlsgt 93 5 cut cut VB cord-345211-4ivqlsgt 93 6 - - HYPH cord-345211-4ivqlsgt 93 7 off off RP cord-345211-4ivqlsgt 93 8 values value NNS cord-345211-4ivqlsgt 93 9 remain remain VBP cord-345211-4ivqlsgt 93 10 to to TO cord-345211-4ivqlsgt 93 11 be be VB cord-345211-4ivqlsgt 93 12 standardized standardize VBN cord-345211-4ivqlsgt 93 13 for for IN cord-345211-4ivqlsgt 93 14 quantitative quantitative JJ cord-345211-4ivqlsgt 93 15 NATs NATs NNP cord-345211-4ivqlsgt 93 16 and and CC cord-345211-4ivqlsgt 93 17 may may MD cord-345211-4ivqlsgt 93 18 vary vary VB cord-345211-4ivqlsgt 93 19 with with IN cord-345211-4ivqlsgt 93 20 patient patient JJ cord-345211-4ivqlsgt 93 21 population population NN cord-345211-4ivqlsgt 93 22 [ [ -LRB- cord-345211-4ivqlsgt 93 23 46 46 CD cord-345211-4ivqlsgt 93 24 ] ] -RRB- cord-345211-4ivqlsgt 93 25 . . . cord-345211-4ivqlsgt 94 1 Microscopy Microscopy NNS cord-345211-4ivqlsgt 94 2 and and CC cord-345211-4ivqlsgt 94 3 culture culture NN cord-345211-4ivqlsgt 94 4 of of IN cord-345211-4ivqlsgt 94 5 lower low JJR cord-345211-4ivqlsgt 94 6 respiratory respiratory JJ cord-345211-4ivqlsgt 94 7 samples sample NNS cord-345211-4ivqlsgt 94 8 remain remain VBP cord-345211-4ivqlsgt 94 9 the the DT cord-345211-4ivqlsgt 94 10 standard standard JJ cord-345211-4ivqlsgt 94 11 diagnostic diagnostic JJ cord-345211-4ivqlsgt 94 12 tools tool NNS cord-345211-4ivqlsgt 94 13 for for IN cord-345211-4ivqlsgt 94 14 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 94 15 . . . cord-345211-4ivqlsgt 95 1 Despite despite IN cord-345211-4ivqlsgt 95 2 improvements improvement NNS cord-345211-4ivqlsgt 95 3 in in IN cord-345211-4ivqlsgt 95 4 culture culture NN cord-345211-4ivqlsgt 95 5 - - HYPH cord-345211-4ivqlsgt 95 6 based base VBN cord-345211-4ivqlsgt 95 7 methods method NNS cord-345211-4ivqlsgt 95 8 , , , cord-345211-4ivqlsgt 95 9 the the DT cord-345211-4ivqlsgt 95 10 slow slow JJ cord-345211-4ivqlsgt 95 11 turnaround turnaround NN cord-345211-4ivqlsgt 95 12 time time NN cord-345211-4ivqlsgt 95 13 for for IN cord-345211-4ivqlsgt 95 14 laboratory laboratory NN cord-345211-4ivqlsgt 95 15 diagnosis diagnosis NN cord-345211-4ivqlsgt 95 16 and and CC cord-345211-4ivqlsgt 95 17 global global JJ cord-345211-4ivqlsgt 95 18 concern concern NN cord-345211-4ivqlsgt 95 19 about about IN cord-345211-4ivqlsgt 95 20 disease disease NN cord-345211-4ivqlsgt 95 21 burden burden NN cord-345211-4ivqlsgt 95 22 and and CC cord-345211-4ivqlsgt 95 23 multidrug multidrug NN cord-345211-4ivqlsgt 95 24 resistance resistance NN cord-345211-4ivqlsgt 95 25 has have VBZ cord-345211-4ivqlsgt 95 26 provided provide VBN cord-345211-4ivqlsgt 95 27 the the DT cord-345211-4ivqlsgt 95 28 impetus impetus NN cord-345211-4ivqlsgt 95 29 for for IN cord-345211-4ivqlsgt 95 30 the the DT cord-345211-4ivqlsgt 95 31 development development NN cord-345211-4ivqlsgt 95 32 of of IN cord-345211-4ivqlsgt 95 33 rapid rapid JJ cord-345211-4ivqlsgt 95 34 testing testing NN cord-345211-4ivqlsgt 95 35 methods method NNS cord-345211-4ivqlsgt 95 36 [ [ -LRB- cord-345211-4ivqlsgt 95 37 47 47 CD cord-345211-4ivqlsgt 95 38 ] ] -RRB- cord-345211-4ivqlsgt 95 39 . . . cord-345211-4ivqlsgt 96 1 Considerable considerable JJ cord-345211-4ivqlsgt 96 2 effort effort NN cord-345211-4ivqlsgt 96 3 has have VBZ cord-345211-4ivqlsgt 96 4 been be VBN cord-345211-4ivqlsgt 96 5 put put VBN cord-345211-4ivqlsgt 96 6 into into IN cord-345211-4ivqlsgt 96 7 the the DT cord-345211-4ivqlsgt 96 8 development development NN cord-345211-4ivqlsgt 96 9 of of IN cord-345211-4ivqlsgt 96 10 NATs NATs NNP cord-345211-4ivqlsgt 96 11 for for IN cord-345211-4ivqlsgt 96 12 Mycobacterium Mycobacterium NNP cord-345211-4ivqlsgt 96 13 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 96 14 , , , cord-345211-4ivqlsgt 96 15 and and CC cord-345211-4ivqlsgt 96 16 several several JJ cord-345211-4ivqlsgt 96 17 commercial commercial JJ cord-345211-4ivqlsgt 96 18 assays assay NNS cord-345211-4ivqlsgt 96 19 are be VBP cord-345211-4ivqlsgt 96 20 now now RB cord-345211-4ivqlsgt 96 21 widely widely RB cord-345211-4ivqlsgt 96 22 available available JJ cord-345211-4ivqlsgt 96 23 [ [ -LRB- cord-345211-4ivqlsgt 96 24 48 48 CD cord-345211-4ivqlsgt 96 25 ] ] -RRB- cord-345211-4ivqlsgt 96 26 . . . cord-345211-4ivqlsgt 97 1 Interestingly interestingly RB cord-345211-4ivqlsgt 97 2 , , , cord-345211-4ivqlsgt 97 3 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 97 4 is be VBZ cord-345211-4ivqlsgt 97 5 unusual unusual JJ cord-345211-4ivqlsgt 97 6 among among IN cord-345211-4ivqlsgt 97 7 infectious infectious JJ cord-345211-4ivqlsgt 97 8 diseases disease NNS cord-345211-4ivqlsgt 97 9 in in IN cord-345211-4ivqlsgt 97 10 that that IN cord-345211-4ivqlsgt 97 11 NATs NATs NNP cord-345211-4ivqlsgt 97 12 are be VBP cord-345211-4ivqlsgt 97 13 less less RBR cord-345211-4ivqlsgt 97 14 sensitive sensitive JJ cord-345211-4ivqlsgt 97 15 than than IN cord-345211-4ivqlsgt 97 16 culture culture NN cord-345211-4ivqlsgt 97 17 , , , cord-345211-4ivqlsgt 97 18 a a DT cord-345211-4ivqlsgt 97 19 possible possible JJ cord-345211-4ivqlsgt 97 20 consequence consequence NN cord-345211-4ivqlsgt 97 21 of of IN cord-345211-4ivqlsgt 97 22 difficulty difficulty NN cord-345211-4ivqlsgt 97 23 with with IN cord-345211-4ivqlsgt 97 24 DNA dna NN cord-345211-4ivqlsgt 97 25 extraction extraction NN cord-345211-4ivqlsgt 97 26 . . . cord-345211-4ivqlsgt 98 1 Sensitivities sensitivity NNS cord-345211-4ivqlsgt 98 2 are be VBP cord-345211-4ivqlsgt 98 3 typically typically RB cord-345211-4ivqlsgt 98 4 92 92 CD cord-345211-4ivqlsgt 98 5 - - SYM cord-345211-4ivqlsgt 98 6 100 100 CD cord-345211-4ivqlsgt 98 7 % % NN cord-345211-4ivqlsgt 98 8 for for IN cord-345211-4ivqlsgt 98 9 smear smear NN cord-345211-4ivqlsgt 98 10 - - HYPH cord-345211-4ivqlsgt 98 11 positive positive JJ cord-345211-4ivqlsgt 98 12 specimens specimen NNS cord-345211-4ivqlsgt 98 13 and and CC cord-345211-4ivqlsgt 98 14 40 40 CD cord-345211-4ivqlsgt 98 15 - - SYM cord-345211-4ivqlsgt 98 16 93 93 CD cord-345211-4ivqlsgt 98 17 % % NN cord-345211-4ivqlsgt 98 18 for for IN cord-345211-4ivqlsgt 98 19 smear smear NN cord-345211-4ivqlsgt 98 20 - - HYPH cord-345211-4ivqlsgt 98 21 negative negative JJ cord-345211-4ivqlsgt 98 22 specimens specimen NNS cord-345211-4ivqlsgt 98 23 [ [ -LRB- cord-345211-4ivqlsgt 98 24 48 48 CD cord-345211-4ivqlsgt 98 25 ] ] -RRB- cord-345211-4ivqlsgt 98 26 . . . cord-345211-4ivqlsgt 99 1 Importantly importantly RB cord-345211-4ivqlsgt 99 2 , , , cord-345211-4ivqlsgt 99 3 small small JJ cord-345211-4ivqlsgt 99 4 , , , cord-345211-4ivqlsgt 99 5 user user NN cord-345211-4ivqlsgt 99 6 - - HYPH cord-345211-4ivqlsgt 99 7 friendly friendly JJ cord-345211-4ivqlsgt 99 8 platforms platform NNS cord-345211-4ivqlsgt 99 9 ( ( -LRB- cord-345211-4ivqlsgt 99 10 such such JJ cord-345211-4ivqlsgt 99 11 as as IN cord-345211-4ivqlsgt 99 12 the the DT cord-345211-4ivqlsgt 99 13 Xpert Xpert NNP cord-345211-4ivqlsgt 99 14 MTB MTB NNP cord-345211-4ivqlsgt 99 15 / / SYM cord-345211-4ivqlsgt 99 16 RIF RIF NNP cord-345211-4ivqlsgt 99 17 assay assay NN cord-345211-4ivqlsgt 99 18 ) ) -RRB- cord-345211-4ivqlsgt 99 19 have have VBP cord-345211-4ivqlsgt 99 20 been be VBN cord-345211-4ivqlsgt 99 21 developed develop VBN cord-345211-4ivqlsgt 99 22 to to IN cord-345211-4ivqlsgt 99 23 an an DT cord-345211-4ivqlsgt 99 24 extent extent NN cord-345211-4ivqlsgt 99 25 that that IN cord-345211-4ivqlsgt 99 26 they -PRON- PRP cord-345211-4ivqlsgt 99 27 have have VBP cord-345211-4ivqlsgt 99 28 been be VBN cord-345211-4ivqlsgt 99 29 successfully successfully RB cord-345211-4ivqlsgt 99 30 deployed deploy VBN cord-345211-4ivqlsgt 99 31 in in IN cord-345211-4ivqlsgt 99 32 many many JJ cord-345211-4ivqlsgt 99 33 resource resource NN cord-345211-4ivqlsgt 99 34 - - HYPH cord-345211-4ivqlsgt 99 35 poor poor JJ cord-345211-4ivqlsgt 99 36 locations location NNS cord-345211-4ivqlsgt 99 37 where where WRB cord-345211-4ivqlsgt 99 38 rapid rapid JJ cord-345211-4ivqlsgt 99 39 diagnostics diagnostic NNS cord-345211-4ivqlsgt 99 40 for for IN cord-345211-4ivqlsgt 99 41 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 99 42 are be VBP cord-345211-4ivqlsgt 99 43 most most RBS cord-345211-4ivqlsgt 99 44 needed need VBN cord-345211-4ivqlsgt 99 45 [ [ -LRB- cord-345211-4ivqlsgt 99 46 47 47 CD cord-345211-4ivqlsgt 99 47 , , , cord-345211-4ivqlsgt 99 48 49 49 CD cord-345211-4ivqlsgt 99 49 ] ] -RRB- cord-345211-4ivqlsgt 99 50 . . . cord-345211-4ivqlsgt 100 1 This this DT cord-345211-4ivqlsgt 100 2 is be VBZ cord-345211-4ivqlsgt 100 3 a a DT cord-345211-4ivqlsgt 100 4 real real JJ cord-345211-4ivqlsgt 100 5 success success NN cord-345211-4ivqlsgt 100 6 story story NN cord-345211-4ivqlsgt 100 7 and and CC cord-345211-4ivqlsgt 100 8 highlights highlight NNS cord-345211-4ivqlsgt 100 9 what what WP cord-345211-4ivqlsgt 100 10 can can MD cord-345211-4ivqlsgt 100 11 be be VB cord-345211-4ivqlsgt 100 12 achieved achieve VBN cord-345211-4ivqlsgt 100 13 with with IN cord-345211-4ivqlsgt 100 14 molecular molecular JJ cord-345211-4ivqlsgt 100 15 diagnostics diagnostic NNS cord-345211-4ivqlsgt 100 16 outside outside IN cord-345211-4ivqlsgt 100 17 major major JJ cord-345211-4ivqlsgt 100 18 laboratories laboratory NNS cord-345211-4ivqlsgt 100 19 . . . cord-345211-4ivqlsgt 101 1 NATs NATs NNP cord-345211-4ivqlsgt 101 2 are be VBP cord-345211-4ivqlsgt 101 3 now now RB cord-345211-4ivqlsgt 101 4 established establish VBN cord-345211-4ivqlsgt 101 5 tests test NNS cord-345211-4ivqlsgt 101 6 for for IN cord-345211-4ivqlsgt 101 7 the the DT cord-345211-4ivqlsgt 101 8 detection detection NN cord-345211-4ivqlsgt 101 9 of of IN cord-345211-4ivqlsgt 101 10 the the DT cord-345211-4ivqlsgt 101 11 causative causative JJ cord-345211-4ivqlsgt 101 12 agents agent NNS cord-345211-4ivqlsgt 101 13 of of IN cord-345211-4ivqlsgt 101 14 pertussis pertussis NN cord-345211-4ivqlsgt 101 15 [ [ -LRB- cord-345211-4ivqlsgt 101 16 50 50 CD cord-345211-4ivqlsgt 101 17 ] ] -RRB- cord-345211-4ivqlsgt 101 18 [ [ -LRB- cord-345211-4ivqlsgt 101 19 51 51 CD cord-345211-4ivqlsgt 101 20 ] ] -RRB- cord-345211-4ivqlsgt 101 21 [ [ -LRB- cord-345211-4ivqlsgt 101 22 52 52 CD cord-345211-4ivqlsgt 101 23 ] ] -RRB- cord-345211-4ivqlsgt 101 24 . . . cord-345211-4ivqlsgt 102 1 While while IN cord-345211-4ivqlsgt 102 2 Bordetella Bordetella NNP cord-345211-4ivqlsgt 102 3 pertussis pertussis NN cord-345211-4ivqlsgt 102 4 is be VBZ cord-345211-4ivqlsgt 102 5 the the DT cord-345211-4ivqlsgt 102 6 major major JJ cord-345211-4ivqlsgt 102 7 cause cause NN cord-345211-4ivqlsgt 102 8 of of IN cord-345211-4ivqlsgt 102 9 pertussis pertussis NN cord-345211-4ivqlsgt 102 10 in in IN cord-345211-4ivqlsgt 102 11 humans human NNS cord-345211-4ivqlsgt 102 12 and and CC cord-345211-4ivqlsgt 102 13 can can MD cord-345211-4ivqlsgt 102 14 be be VB cord-345211-4ivqlsgt 102 15 complicated complicate VBN cord-345211-4ivqlsgt 102 16 by by IN cord-345211-4ivqlsgt 102 17 pneumonia pneumonia NN cord-345211-4ivqlsgt 102 18 [ [ -LRB- cord-345211-4ivqlsgt 102 19 53 53 CD cord-345211-4ivqlsgt 102 20 , , , cord-345211-4ivqlsgt 102 21 54 54 CD cord-345211-4ivqlsgt 102 22 ] ] -RRB- cord-345211-4ivqlsgt 102 23 , , , cord-345211-4ivqlsgt 102 24 Bordetella Bordetella NNP cord-345211-4ivqlsgt 102 25 bronchiseptica bronchiseptica NNP cord-345211-4ivqlsgt 102 26 , , , cord-345211-4ivqlsgt 102 27 Bordetella Bordetella NNP cord-345211-4ivqlsgt 102 28 holmesii holmesii NNP cord-345211-4ivqlsgt 102 29 , , , cord-345211-4ivqlsgt 102 30 and and CC cord-345211-4ivqlsgt 102 31 Bordetella Bordetella NNP cord-345211-4ivqlsgt 102 32 parapertussis parapertussi NNS cord-345211-4ivqlsgt 102 33 have have VBP cord-345211-4ivqlsgt 102 34 all all DT cord-345211-4ivqlsgt 102 35 been be VBN cord-345211-4ivqlsgt 102 36 occasionally occasionally RB cord-345211-4ivqlsgt 102 37 associated associate VBN cord-345211-4ivqlsgt 102 38 with with IN cord-345211-4ivqlsgt 102 39 ( ( -LRB- cord-345211-4ivqlsgt 102 40 often often RB cord-345211-4ivqlsgt 102 41 milder mild JJR cord-345211-4ivqlsgt 102 42 ) ) -RRB- cord-345211-4ivqlsgt 102 43 pertussis pertussis NN cord-345211-4ivqlsgt 102 44 - - HYPH cord-345211-4ivqlsgt 102 45 like like JJ cord-345211-4ivqlsgt 102 46 illnesses illness NNS cord-345211-4ivqlsgt 102 47 [ [ -LRB- cord-345211-4ivqlsgt 102 48 50 50 CD cord-345211-4ivqlsgt 102 49 ] ] -RRB- cord-345211-4ivqlsgt 102 50 . . . cord-345211-4ivqlsgt 103 1 NATs NATs NNP cord-345211-4ivqlsgt 103 2 are be VBP cord-345211-4ivqlsgt 103 3 the the DT cord-345211-4ivqlsgt 103 4 most most RBS cord-345211-4ivqlsgt 103 5 sensitive sensitive JJ cord-345211-4ivqlsgt 103 6 methods method NNS cord-345211-4ivqlsgt 103 7 for for IN cord-345211-4ivqlsgt 103 8 the the DT cord-345211-4ivqlsgt 103 9 detection detection NN cord-345211-4ivqlsgt 103 10 of of IN cord-345211-4ivqlsgt 103 11 B. B. NNP cord-345211-4ivqlsgt 103 12 pertussis pertussis NN cord-345211-4ivqlsgt 103 13 and and CC cord-345211-4ivqlsgt 103 14 , , , cord-345211-4ivqlsgt 103 15 with with IN cord-345211-4ivqlsgt 103 16 rapid rapid JJ cord-345211-4ivqlsgt 103 17 turnaround turnaround NN cord-345211-4ivqlsgt 103 18 times time NNS cord-345211-4ivqlsgt 103 19 , , , cord-345211-4ivqlsgt 103 20 have have VBP cord-345211-4ivqlsgt 103 21 been be VBN cord-345211-4ivqlsgt 103 22 invaluable invaluable JJ cord-345211-4ivqlsgt 103 23 tools tool NNS cord-345211-4ivqlsgt 103 24 in in IN cord-345211-4ivqlsgt 103 25 outbreak outbreak NN cord-345211-4ivqlsgt 103 26 management management NN cord-345211-4ivqlsgt 103 27 [ [ -LRB- cord-345211-4ivqlsgt 103 28 55 55 CD cord-345211-4ivqlsgt 103 29 , , , cord-345211-4ivqlsgt 103 30 56 56 CD cord-345211-4ivqlsgt 103 31 ] ] -RRB- cord-345211-4ivqlsgt 103 32 . . . cord-345211-4ivqlsgt 104 1 The the DT cord-345211-4ivqlsgt 104 2 main main JJ cord-345211-4ivqlsgt 104 3 limitation limitation NN cord-345211-4ivqlsgt 104 4 of of IN cord-345211-4ivqlsgt 104 5 B. B. NNP cord-345211-4ivqlsgt 104 6 pertussis pertussis NN cord-345211-4ivqlsgt 104 7 NATs NATs NNP cord-345211-4ivqlsgt 104 8 is be VBZ cord-345211-4ivqlsgt 104 9 specificity specificity NN cord-345211-4ivqlsgt 104 10 , , , cord-345211-4ivqlsgt 104 11 particularly particularly RB cord-345211-4ivqlsgt 104 12 the the DT cord-345211-4ivqlsgt 104 13 ability ability NN cord-345211-4ivqlsgt 104 14 of of IN cord-345211-4ivqlsgt 104 15 the the DT cord-345211-4ivqlsgt 104 16 most most RBS cord-345211-4ivqlsgt 104 17 widely widely RB cord-345211-4ivqlsgt 104 18 used use VBN cord-345211-4ivqlsgt 104 19 ( ( -LRB- cord-345211-4ivqlsgt 104 20 IS481-based is481-base VBN cord-345211-4ivqlsgt 104 21 ) ) -RRB- cord-345211-4ivqlsgt 104 22 assays assay NNS cord-345211-4ivqlsgt 104 23 to to TO cord-345211-4ivqlsgt 104 24 also also RB cord-345211-4ivqlsgt 104 25 detect detect VB cord-345211-4ivqlsgt 104 26 B. B. NNP cord-345211-4ivqlsgt 104 27 holmesii holmesii NNP cord-345211-4ivqlsgt 104 28 , , , cord-345211-4ivqlsgt 104 29 which which WDT cord-345211-4ivqlsgt 104 30 is be VBZ cord-345211-4ivqlsgt 104 31 generally generally RB cord-345211-4ivqlsgt 104 32 considered consider VBN cord-345211-4ivqlsgt 104 33 a a DT cord-345211-4ivqlsgt 104 34 false false JJ cord-345211-4ivqlsgt 104 35 positive positive JJ cord-345211-4ivqlsgt 104 36 result result NN cord-345211-4ivqlsgt 104 37 [ [ -LRB- cord-345211-4ivqlsgt 104 38 50 50 CD cord-345211-4ivqlsgt 104 39 ] ] -RRB- cord-345211-4ivqlsgt 104 40 . . . cord-345211-4ivqlsgt 105 1 The the DT cord-345211-4ivqlsgt 105 2 use use NN cord-345211-4ivqlsgt 105 3 of of IN cord-345211-4ivqlsgt 105 4 dual dual JJ cord-345211-4ivqlsgt 105 5 target target NN cord-345211-4ivqlsgt 105 6 assays assay NNS cord-345211-4ivqlsgt 105 7 has have VBZ cord-345211-4ivqlsgt 105 8 been be VBN cord-345211-4ivqlsgt 105 9 advocated advocate VBN cord-345211-4ivqlsgt 105 10 to to TO cord-345211-4ivqlsgt 105 11 overcome overcome VB cord-345211-4ivqlsgt 105 12 this this DT cord-345211-4ivqlsgt 105 13 potential potential JJ cord-345211-4ivqlsgt 105 14 problem problem NN cord-345211-4ivqlsgt 105 15 [ [ -LRB- cord-345211-4ivqlsgt 105 16 52 52 CD cord-345211-4ivqlsgt 105 17 ] ] -RRB- cord-345211-4ivqlsgt 105 18 . . . cord-345211-4ivqlsgt 106 1 What what WP cord-345211-4ivqlsgt 106 2 are be VBP cord-345211-4ivqlsgt 106 3 the the DT cord-345211-4ivqlsgt 106 4 limitations limitation NNS cord-345211-4ivqlsgt 106 5 of of IN cord-345211-4ivqlsgt 106 6 molecular molecular JJ cord-345211-4ivqlsgt 106 7 diagnostic diagnostic JJ cord-345211-4ivqlsgt 106 8 tests test NNS cord-345211-4ivqlsgt 106 9 for for IN cord-345211-4ivqlsgt 106 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 106 11 and and CC cord-345211-4ivqlsgt 106 12 what what WP cord-345211-4ivqlsgt 106 13 needs need VBZ cord-345211-4ivqlsgt 106 14 to to TO cord-345211-4ivqlsgt 106 15 be be VB cord-345211-4ivqlsgt 106 16 addressed address VBN cord-345211-4ivqlsgt 106 17 in in IN cord-345211-4ivqlsgt 106 18 order order NN cord-345211-4ivqlsgt 106 19 to to TO cord-345211-4ivqlsgt 106 20 progress progress VB cord-345211-4ivqlsgt 106 21 with with IN cord-345211-4ivqlsgt 106 22 development development NN cord-345211-4ivqlsgt 106 23 ? ? . cord-345211-4ivqlsgt 107 1 Common common JJ cord-345211-4ivqlsgt 107 2 to to IN cord-345211-4ivqlsgt 107 3 all all DT cord-345211-4ivqlsgt 107 4 pneumonia pneumonia NN cord-345211-4ivqlsgt 107 5 diagnostic diagnostic JJ cord-345211-4ivqlsgt 107 6 testing testing NN cord-345211-4ivqlsgt 107 7 , , , cord-345211-4ivqlsgt 107 8 the the DT cord-345211-4ivqlsgt 107 9 inability inability NN cord-345211-4ivqlsgt 107 10 to to TO cord-345211-4ivqlsgt 107 11 obtain obtain VB cord-345211-4ivqlsgt 107 12 good good JJ cord-345211-4ivqlsgt 107 13 quality quality NN cord-345211-4ivqlsgt 107 14 specimens specimen NNS cord-345211-4ivqlsgt 107 15 from from IN cord-345211-4ivqlsgt 107 16 the the DT cord-345211-4ivqlsgt 107 17 lower low JJR cord-345211-4ivqlsgt 107 18 respiratory respiratory JJ cord-345211-4ivqlsgt 107 19 tract tract NN cord-345211-4ivqlsgt 107 20 is be VBZ cord-345211-4ivqlsgt 107 21 a a DT cord-345211-4ivqlsgt 107 22 major major JJ cord-345211-4ivqlsgt 107 23 problem problem NN cord-345211-4ivqlsgt 107 24 that that WDT cord-345211-4ivqlsgt 107 25 will will MD cord-345211-4ivqlsgt 107 26 only only RB cord-345211-4ivqlsgt 107 27 be be VB cord-345211-4ivqlsgt 107 28 overcome overcome VBN cord-345211-4ivqlsgt 107 29 through through IN cord-345211-4ivqlsgt 107 30 new new JJ cord-345211-4ivqlsgt 107 31 innovative innovative JJ cord-345211-4ivqlsgt 107 32 and and CC cord-345211-4ivqlsgt 107 33 safe safe JJ cord-345211-4ivqlsgt 107 34 methods method NNS cord-345211-4ivqlsgt 107 35 of of IN cord-345211-4ivqlsgt 107 36 specimen specimen JJ cord-345211-4ivqlsgt 107 37 collection collection NN cord-345211-4ivqlsgt 107 38 and and CC cord-345211-4ivqlsgt 107 39 a a DT cord-345211-4ivqlsgt 107 40 greater great JJR cord-345211-4ivqlsgt 107 41 understanding understanding NN cord-345211-4ivqlsgt 107 42 of of IN cord-345211-4ivqlsgt 107 43 the the DT cord-345211-4ivqlsgt 107 44 relationships relationship NNS cord-345211-4ivqlsgt 107 45 between between IN cord-345211-4ivqlsgt 107 46 changes change NNS cord-345211-4ivqlsgt 107 47 in in IN cord-345211-4ivqlsgt 107 48 the the DT cord-345211-4ivqlsgt 107 49 lung lung NN cord-345211-4ivqlsgt 107 50 and and CC cord-345211-4ivqlsgt 107 51 in in IN cord-345211-4ivqlsgt 107 52 more more RBR cord-345211-4ivqlsgt 107 53 distant distant JJ cord-345211-4ivqlsgt 107 54 specimens specimen NNS cord-345211-4ivqlsgt 107 55 in in IN cord-345211-4ivqlsgt 107 56 pneumonia pneumonia NN cord-345211-4ivqlsgt 107 57 . . . cord-345211-4ivqlsgt 108 1 A a DT cord-345211-4ivqlsgt 108 2 second second JJ cord-345211-4ivqlsgt 108 3 - - HYPH cord-345211-4ivqlsgt 108 4 major major JJ cord-345211-4ivqlsgt 108 5 limitation limitation NN cord-345211-4ivqlsgt 108 6 of of IN cord-345211-4ivqlsgt 108 7 NATs NATs NNP cord-345211-4ivqlsgt 108 8 is be VBZ cord-345211-4ivqlsgt 108 9 their -PRON- PRP$ cord-345211-4ivqlsgt 108 10 inability inability NN cord-345211-4ivqlsgt 108 11 to to TO cord-345211-4ivqlsgt 108 12 distinguish distinguish VB cord-345211-4ivqlsgt 108 13 pathogens pathogen NNS cord-345211-4ivqlsgt 108 14 from from IN cord-345211-4ivqlsgt 108 15 innocent innocent JJ cord-345211-4ivqlsgt 108 16 bystanders bystander NNS cord-345211-4ivqlsgt 108 17 . . . cord-345211-4ivqlsgt 109 1 In in IN cord-345211-4ivqlsgt 109 2 essence essence NN cord-345211-4ivqlsgt 109 3 , , , cord-345211-4ivqlsgt 109 4 we -PRON- PRP cord-345211-4ivqlsgt 109 5 need need VBP cord-345211-4ivqlsgt 109 6 two two CD cord-345211-4ivqlsgt 109 7 pieces piece NNS cord-345211-4ivqlsgt 109 8 of of IN cord-345211-4ivqlsgt 109 9 information information NN cord-345211-4ivqlsgt 109 10 . . . cord-345211-4ivqlsgt 110 1 First first RB cord-345211-4ivqlsgt 110 2 , , , cord-345211-4ivqlsgt 110 3 is be VBZ cord-345211-4ivqlsgt 110 4 a a DT cord-345211-4ivqlsgt 110 5 particular particular JJ cord-345211-4ivqlsgt 110 6 microorganism microorganism NN cord-345211-4ivqlsgt 110 7 present present JJ cord-345211-4ivqlsgt 110 8 in in IN cord-345211-4ivqlsgt 110 9 the the DT cord-345211-4ivqlsgt 110 10 clinical clinical JJ cord-345211-4ivqlsgt 110 11 specimen specimen NN cord-345211-4ivqlsgt 110 12 ? ? . cord-345211-4ivqlsgt 111 1 Second second RB cord-345211-4ivqlsgt 111 2 , , , cord-345211-4ivqlsgt 111 3 if if IN cord-345211-4ivqlsgt 111 4 the the DT cord-345211-4ivqlsgt 111 5 microorganism microorganism NN cord-345211-4ivqlsgt 111 6 is be VBZ cord-345211-4ivqlsgt 111 7 present present JJ cord-345211-4ivqlsgt 111 8 , , , cord-345211-4ivqlsgt 111 9 is be VBZ cord-345211-4ivqlsgt 111 10 it -PRON- PRP cord-345211-4ivqlsgt 111 11 causing cause VBG cord-345211-4ivqlsgt 111 12 this this DT cord-345211-4ivqlsgt 111 13 episode episode NN cord-345211-4ivqlsgt 111 14 of of IN cord-345211-4ivqlsgt 111 15 pneumonia pneumonia NN cord-345211-4ivqlsgt 111 16 ? ? . cord-345211-4ivqlsgt 112 1 To to IN cord-345211-4ivqlsgt 112 2 date date NN cord-345211-4ivqlsgt 112 3 , , , cord-345211-4ivqlsgt 112 4 diagnostic diagnostic JJ cord-345211-4ivqlsgt 112 5 efforts effort NNS cord-345211-4ivqlsgt 112 6 have have VBP cord-345211-4ivqlsgt 112 7 focused focus VBN cord-345211-4ivqlsgt 112 8 almost almost RB cord-345211-4ivqlsgt 112 9 exclusively exclusively RB cord-345211-4ivqlsgt 112 10 on on IN cord-345211-4ivqlsgt 112 11 the the DT cord-345211-4ivqlsgt 112 12 first first JJ cord-345211-4ivqlsgt 112 13 question question NN cord-345211-4ivqlsgt 112 14 and and CC cord-345211-4ivqlsgt 112 15 have have VBP cord-345211-4ivqlsgt 112 16 ignored ignore VBN cord-345211-4ivqlsgt 112 17 the the DT cord-345211-4ivqlsgt 112 18 second second JJ cord-345211-4ivqlsgt 112 19 , , , cord-345211-4ivqlsgt 112 20 which which WDT cord-345211-4ivqlsgt 112 21 is be VBZ cord-345211-4ivqlsgt 112 22 usually usually RB cord-345211-4ivqlsgt 112 23 much much RB cord-345211-4ivqlsgt 112 24 more more RBR cord-345211-4ivqlsgt 112 25 difficult difficult JJ cord-345211-4ivqlsgt 112 26 to to TO cord-345211-4ivqlsgt 112 27 answer answer VB cord-345211-4ivqlsgt 112 28 unless unless IN cord-345211-4ivqlsgt 112 29 the the DT cord-345211-4ivqlsgt 112 30 microorganism microorganism NN cord-345211-4ivqlsgt 112 31 is be VBZ cord-345211-4ivqlsgt 112 32 never never RB cord-345211-4ivqlsgt 112 33 present present JJ cord-345211-4ivqlsgt 112 34 as as IN cord-345211-4ivqlsgt 112 35 a a DT cord-345211-4ivqlsgt 112 36 colonizer colonizer NN cord-345211-4ivqlsgt 112 37 ( ( -LRB- cord-345211-4ivqlsgt 112 38 e.g. e.g. RB cord-345211-4ivqlsgt 112 39 Legionella Legionella NNP cord-345211-4ivqlsgt 112 40 spp spp NNP cord-345211-4ivqlsgt 112 41 . . . cord-345211-4ivqlsgt 112 42 ) ) -RRB- cord-345211-4ivqlsgt 112 43 . . . cord-345211-4ivqlsgt 113 1 The the DT cord-345211-4ivqlsgt 113 2 efforts effort NNS cord-345211-4ivqlsgt 113 3 to to TO cord-345211-4ivqlsgt 113 4 use use VB cord-345211-4ivqlsgt 113 5 NATs NATs NNP cord-345211-4ivqlsgt 113 6 as as IN cord-345211-4ivqlsgt 113 7 a a DT cord-345211-4ivqlsgt 113 8 diagnostic diagnostic NN cord-345211-4ivqlsgt 113 9 for for IN cord-345211-4ivqlsgt 113 10 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 113 11 pneumonia pneumonia NN cord-345211-4ivqlsgt 113 12 illustrate illustrate VBP cord-345211-4ivqlsgt 113 13 some some DT cord-345211-4ivqlsgt 113 14 of of IN cord-345211-4ivqlsgt 113 15 the the DT cord-345211-4ivqlsgt 113 16 key key JJ cord-345211-4ivqlsgt 113 17 issues issue NNS cord-345211-4ivqlsgt 113 18 . . . cord-345211-4ivqlsgt 114 1 S. S. NNP cord-345211-4ivqlsgt 114 2 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 114 3 is be VBZ cord-345211-4ivqlsgt 114 4 regarded regard VBN cord-345211-4ivqlsgt 114 5 as as IN cord-345211-4ivqlsgt 114 6 the the DT cord-345211-4ivqlsgt 114 7 most most RBS cord-345211-4ivqlsgt 114 8 common common JJ cord-345211-4ivqlsgt 114 9 cause cause NN cord-345211-4ivqlsgt 114 10 of of IN cord-345211-4ivqlsgt 114 11 pneumonia pneumonia NN cord-345211-4ivqlsgt 114 12 in in IN cord-345211-4ivqlsgt 114 13 all all DT cord-345211-4ivqlsgt 114 14 age age NN cord-345211-4ivqlsgt 114 15 groups group NNS cord-345211-4ivqlsgt 114 16 and and CC cord-345211-4ivqlsgt 114 17 yet yet RB cord-345211-4ivqlsgt 114 18 , , , cord-345211-4ivqlsgt 114 19 molecular molecular JJ cord-345211-4ivqlsgt 114 20 tests test NNS cord-345211-4ivqlsgt 114 21 do do VBP cord-345211-4ivqlsgt 114 22 not not RB cord-345211-4ivqlsgt 114 23 have have VB cord-345211-4ivqlsgt 114 24 an an DT cord-345211-4ivqlsgt 114 25 established establish VBN cord-345211-4ivqlsgt 114 26 diagnostic diagnostic JJ cord-345211-4ivqlsgt 114 27 role role NN cord-345211-4ivqlsgt 114 28 [ [ -LRB- cord-345211-4ivqlsgt 114 29 57 57 CD cord-345211-4ivqlsgt 114 30 ] ] -RRB- cord-345211-4ivqlsgt 114 31 . . . cord-345211-4ivqlsgt 115 1 S. S. NNP cord-345211-4ivqlsgt 115 2 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 115 3 is be VBZ cord-345211-4ivqlsgt 115 4 also also RB cord-345211-4ivqlsgt 115 5 a a DT cord-345211-4ivqlsgt 115 6 common common JJ cord-345211-4ivqlsgt 115 7 nasopharyngeal nasopharyngeal JJ cord-345211-4ivqlsgt 115 8 colonizer colonizer NN cord-345211-4ivqlsgt 115 9 , , , cord-345211-4ivqlsgt 115 10 with with IN cord-345211-4ivqlsgt 115 11 carriage carriage NN cord-345211-4ivqlsgt 115 12 prevalence prevalence NN cord-345211-4ivqlsgt 115 13 exceeding exceed VBG cord-345211-4ivqlsgt 115 14 50 50 CD cord-345211-4ivqlsgt 115 15 % % NN cord-345211-4ivqlsgt 115 16 among among IN cord-345211-4ivqlsgt 115 17 children child NNS cord-345211-4ivqlsgt 115 18 in in IN cord-345211-4ivqlsgt 115 19 some some DT cord-345211-4ivqlsgt 115 20 regions region NNS cord-345211-4ivqlsgt 115 21 of of IN cord-345211-4ivqlsgt 115 22 the the DT cord-345211-4ivqlsgt 115 23 world world NN cord-345211-4ivqlsgt 115 24 [ [ -LRB- cord-345211-4ivqlsgt 115 25 58 58 CD cord-345211-4ivqlsgt 115 26 ] ] -RRB- cord-345211-4ivqlsgt 115 27 . . . cord-345211-4ivqlsgt 116 1 Earlier early RBR cord-345211-4ivqlsgt 116 2 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 116 3 PCR pcr NN cord-345211-4ivqlsgt 116 4 assays assay NNS cord-345211-4ivqlsgt 116 5 , , , cord-345211-4ivqlsgt 116 6 such such JJ cord-345211-4ivqlsgt 116 7 as as IN cord-345211-4ivqlsgt 116 8 those those DT cord-345211-4ivqlsgt 116 9 targeting target VBG cord-345211-4ivqlsgt 116 10 the the DT cord-345211-4ivqlsgt 116 11 pneumolysin pneumolysin NNP cord-345211-4ivqlsgt 116 12 gene gene NN cord-345211-4ivqlsgt 116 13 , , , cord-345211-4ivqlsgt 116 14 had have VBD cord-345211-4ivqlsgt 116 15 problems problem NNS cord-345211-4ivqlsgt 116 16 of of IN cord-345211-4ivqlsgt 116 17 poor poor JJ cord-345211-4ivqlsgt 116 18 specificity specificity NN cord-345211-4ivqlsgt 116 19 due due IN cord-345211-4ivqlsgt 116 20 to to IN cord-345211-4ivqlsgt 116 21 detection detection NN cord-345211-4ivqlsgt 116 22 of of IN cord-345211-4ivqlsgt 116 23 other other JJ cord-345211-4ivqlsgt 116 24 , , , cord-345211-4ivqlsgt 116 25 closely closely RB cord-345211-4ivqlsgt 116 26 related related JJ cord-345211-4ivqlsgt 116 27 streptococci streptococcus NNS cord-345211-4ivqlsgt 116 28 [ [ -LRB- cord-345211-4ivqlsgt 116 29 59 59 CD cord-345211-4ivqlsgt 116 30 ] ] -RRB- cord-345211-4ivqlsgt 116 31 , , , cord-345211-4ivqlsgt 116 32 although although IN cord-345211-4ivqlsgt 116 33 false false JJ cord-345211-4ivqlsgt 116 34 - - HYPH cord-345211-4ivqlsgt 116 35 positive positive JJ cord-345211-4ivqlsgt 116 36 results result NNS cord-345211-4ivqlsgt 116 37 are be VBP cord-345211-4ivqlsgt 116 38 less less RBR cord-345211-4ivqlsgt 116 39 likely likely JJ cord-345211-4ivqlsgt 116 40 with with IN cord-345211-4ivqlsgt 116 41 some some DT cord-345211-4ivqlsgt 116 42 of of IN cord-345211-4ivqlsgt 116 43 the the DT cord-345211-4ivqlsgt 116 44 currently currently RB cord-345211-4ivqlsgt 116 45 more more RBR cord-345211-4ivqlsgt 116 46 widely widely RB cord-345211-4ivqlsgt 116 47 used use VBN cord-345211-4ivqlsgt 116 48 targets target NNS cord-345211-4ivqlsgt 116 49 ( ( -LRB- cord-345211-4ivqlsgt 116 50 e.g. e.g. RB cord-345211-4ivqlsgt 116 51 autolysin autolysin NNP cord-345211-4ivqlsgt 116 52 gene gene NN cord-345211-4ivqlsgt 116 53 ) ) -RRB- cord-345211-4ivqlsgt 116 54 [ [ -LRB- cord-345211-4ivqlsgt 116 55 60 60 CD cord-345211-4ivqlsgt 116 56 ] ] -RRB- cord-345211-4ivqlsgt 116 57 . . . cord-345211-4ivqlsgt 117 1 S. S. NNP cord-345211-4ivqlsgt 117 2 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 117 3 is be VBZ cord-345211-4ivqlsgt 117 4 frequently frequently RB cord-345211-4ivqlsgt 117 5 detected detect VBN cord-345211-4ivqlsgt 117 6 by by IN cord-345211-4ivqlsgt 117 7 NATs nat NNS cord-345211-4ivqlsgt 117 8 in in IN cord-345211-4ivqlsgt 117 9 both both CC cord-345211-4ivqlsgt 117 10 upper upper JJ cord-345211-4ivqlsgt 117 11 and and CC cord-345211-4ivqlsgt 117 12 lower low JJR cord-345211-4ivqlsgt 117 13 respiratory respiratory JJ cord-345211-4ivqlsgt 117 14 specimens specimen NNS cord-345211-4ivqlsgt 117 15 from from IN cord-345211-4ivqlsgt 117 16 patients patient NNS cord-345211-4ivqlsgt 117 17 with with IN cord-345211-4ivqlsgt 117 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 117 19 [ [ -LRB- cord-345211-4ivqlsgt 117 20 59 59 CD cord-345211-4ivqlsgt 117 21 ] ] -RRB- cord-345211-4ivqlsgt 117 22 , , , cord-345211-4ivqlsgt 117 23 but but CC cord-345211-4ivqlsgt 117 24 the the DT cord-345211-4ivqlsgt 117 25 clinical clinical JJ cord-345211-4ivqlsgt 117 26 implications implication NNS cord-345211-4ivqlsgt 117 27 of of IN cord-345211-4ivqlsgt 117 28 a a DT cord-345211-4ivqlsgt 117 29 positive positive JJ cord-345211-4ivqlsgt 117 30 result result NN cord-345211-4ivqlsgt 117 31 are be VBP cord-345211-4ivqlsgt 117 32 uncertain uncertain JJ cord-345211-4ivqlsgt 117 33 given give VBN cord-345211-4ivqlsgt 117 34 the the DT cord-345211-4ivqlsgt 117 35 relative relative JJ cord-345211-4ivqlsgt 117 36 high high JJ cord-345211-4ivqlsgt 117 37 prevalence prevalence NN cord-345211-4ivqlsgt 117 38 of of IN cord-345211-4ivqlsgt 117 39 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 117 40 carriage carriage NN cord-345211-4ivqlsgt 117 41 . . . cord-345211-4ivqlsgt 118 1 Testing testing NN cord-345211-4ivqlsgt 118 2 of of IN cord-345211-4ivqlsgt 118 3 blood blood NN cord-345211-4ivqlsgt 118 4 for for IN cord-345211-4ivqlsgt 118 5 S. S. NNP cord-345211-4ivqlsgt 118 6 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 118 7 by by IN cord-345211-4ivqlsgt 118 8 PCR PCR NNP cord-345211-4ivqlsgt 118 9 has have VBZ cord-345211-4ivqlsgt 118 10 been be VBN cord-345211-4ivqlsgt 118 11 promoted promote VBN cord-345211-4ivqlsgt 118 12 as as IN cord-345211-4ivqlsgt 118 13 an an DT cord-345211-4ivqlsgt 118 14 alternative alternative JJ cord-345211-4ivqlsgt 118 15 approach approach NN cord-345211-4ivqlsgt 118 16 that that WDT cord-345211-4ivqlsgt 118 17 can can MD cord-345211-4ivqlsgt 118 18 potentially potentially RB cord-345211-4ivqlsgt 118 19 avoid avoid VB cord-345211-4ivqlsgt 118 20 issues issue NNS cord-345211-4ivqlsgt 118 21 of of IN cord-345211-4ivqlsgt 118 22 contamination contamination NN cord-345211-4ivqlsgt 118 23 . . . cord-345211-4ivqlsgt 119 1 Among among IN cord-345211-4ivqlsgt 119 2 Italian italian JJ cord-345211-4ivqlsgt 119 3 children child NNS cord-345211-4ivqlsgt 119 4 , , , cord-345211-4ivqlsgt 119 5 blood blood NN cord-345211-4ivqlsgt 119 6 PCR PCR NNP cord-345211-4ivqlsgt 119 7 showed show VBD cord-345211-4ivqlsgt 119 8 promise promise NN cord-345211-4ivqlsgt 119 9 as as IN cord-345211-4ivqlsgt 119 10 a a DT cord-345211-4ivqlsgt 119 11 diagnostic diagnostic NN cord-345211-4ivqlsgt 119 12 for for IN cord-345211-4ivqlsgt 119 13 invasive invasive JJ cord-345211-4ivqlsgt 119 14 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 119 15 disease disease NN cord-345211-4ivqlsgt 119 16 [ [ -LRB- cord-345211-4ivqlsgt 119 17 61 61 CD cord-345211-4ivqlsgt 119 18 ] ] -RRB- cord-345211-4ivqlsgt 119 19 [ [ -LRB- cord-345211-4ivqlsgt 119 20 62 62 CD cord-345211-4ivqlsgt 119 21 ] ] -RRB- cord-345211-4ivqlsgt 119 22 [ [ -LRB- cord-345211-4ivqlsgt 119 23 63 63 CD cord-345211-4ivqlsgt 119 24 ] ] -RRB- cord-345211-4ivqlsgt 119 25 [ [ -LRB- cord-345211-4ivqlsgt 119 26 64 64 CD cord-345211-4ivqlsgt 119 27 ] ] -RRB- cord-345211-4ivqlsgt 120 1 with with IN cord-345211-4ivqlsgt 120 2 high high JJ cord-345211-4ivqlsgt 120 3 specificity specificity NN cord-345211-4ivqlsgt 120 4 [ [ -LRB- cord-345211-4ivqlsgt 120 5 65 65 CD cord-345211-4ivqlsgt 120 6 ] ] -RRB- cord-345211-4ivqlsgt 120 7 . . . cord-345211-4ivqlsgt 121 1 However however RB cord-345211-4ivqlsgt 121 2 , , , cord-345211-4ivqlsgt 121 3 in in IN cord-345211-4ivqlsgt 121 4 other other JJ cord-345211-4ivqlsgt 121 5 populations population NNS cord-345211-4ivqlsgt 121 6 , , , cord-345211-4ivqlsgt 121 7 positive positive JJ cord-345211-4ivqlsgt 121 8 results result NNS cord-345211-4ivqlsgt 121 9 have have VBP cord-345211-4ivqlsgt 121 10 been be VBN cord-345211-4ivqlsgt 121 11 reported report VBN cord-345211-4ivqlsgt 121 12 in in IN cord-345211-4ivqlsgt 121 13 control control NN cord-345211-4ivqlsgt 121 14 participants participant NNS cord-345211-4ivqlsgt 121 15 who who WP cord-345211-4ivqlsgt 121 16 do do VBP cord-345211-4ivqlsgt 121 17 not not RB cord-345211-4ivqlsgt 121 18 have have VB cord-345211-4ivqlsgt 121 19 suspected suspect VBN cord-345211-4ivqlsgt 121 20 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 121 21 disease disease NN cord-345211-4ivqlsgt 121 22 [ [ -LRB- cord-345211-4ivqlsgt 121 23 66 66 CD cord-345211-4ivqlsgt 121 24 ] ] -RRB- cord-345211-4ivqlsgt 121 25 , , , cord-345211-4ivqlsgt 121 26 raising raise VBG cord-345211-4ivqlsgt 121 27 concerns concern NNS cord-345211-4ivqlsgt 121 28 about about IN cord-345211-4ivqlsgt 121 29 the the DT cord-345211-4ivqlsgt 121 30 broader broad JJR cord-345211-4ivqlsgt 121 31 utility utility NN cord-345211-4ivqlsgt 121 32 of of IN cord-345211-4ivqlsgt 121 33 this this DT cord-345211-4ivqlsgt 121 34 approach approach NN cord-345211-4ivqlsgt 121 35 . . . cord-345211-4ivqlsgt 122 1 In in IN cord-345211-4ivqlsgt 122 2 particular particular JJ cord-345211-4ivqlsgt 122 3 , , , cord-345211-4ivqlsgt 122 4 false false JJ cord-345211-4ivqlsgt 122 5 - - HYPH cord-345211-4ivqlsgt 122 6 positive positive JJ cord-345211-4ivqlsgt 122 7 results result NNS cord-345211-4ivqlsgt 122 8 are be VBP cord-345211-4ivqlsgt 122 9 relatively relatively RB cord-345211-4ivqlsgt 122 10 common common JJ cord-345211-4ivqlsgt 122 11 in in IN cord-345211-4ivqlsgt 122 12 children child NNS cord-345211-4ivqlsgt 122 13 from from IN cord-345211-4ivqlsgt 122 14 developing develop VBG cord-345211-4ivqlsgt 122 15 countries country NNS cord-345211-4ivqlsgt 122 16 where where WRB cord-345211-4ivqlsgt 122 17 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 122 18 carriage carriage NN cord-345211-4ivqlsgt 122 19 is be VBZ cord-345211-4ivqlsgt 122 20 common common JJ cord-345211-4ivqlsgt 122 21 [ [ -LRB- cord-345211-4ivqlsgt 122 22 67 67 CD cord-345211-4ivqlsgt 122 23 ] ] -RRB- cord-345211-4ivqlsgt 122 24 . . . cord-345211-4ivqlsgt 123 1 Consequently consequently RB cord-345211-4ivqlsgt 123 2 , , , cord-345211-4ivqlsgt 123 3 a a DT cord-345211-4ivqlsgt 123 4 positive positive JJ cord-345211-4ivqlsgt 123 5 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 123 6 NAT NAT NNP cord-345211-4ivqlsgt 123 7 result result NN cord-345211-4ivqlsgt 123 8 alone alone RB cord-345211-4ivqlsgt 123 9 is be VBZ cord-345211-4ivqlsgt 123 10 usually usually RB cord-345211-4ivqlsgt 123 11 not not RB cord-345211-4ivqlsgt 123 12 enough enough JJ cord-345211-4ivqlsgt 123 13 to to TO cord-345211-4ivqlsgt 123 14 diagnose diagnose VB cord-345211-4ivqlsgt 123 15 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 123 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 123 17 . . . cord-345211-4ivqlsgt 124 1 The the DT cord-345211-4ivqlsgt 124 2 possible possible JJ cord-345211-4ivqlsgt 124 3 exception exception NN cord-345211-4ivqlsgt 124 4 is be VBZ cord-345211-4ivqlsgt 124 5 the the DT cord-345211-4ivqlsgt 124 6 use use NN cord-345211-4ivqlsgt 124 7 of of IN cord-345211-4ivqlsgt 124 8 NATs NATs NNP cord-345211-4ivqlsgt 124 9 to to TO cord-345211-4ivqlsgt 124 10 detect detect VB cord-345211-4ivqlsgt 124 11 S. S. NNP cord-345211-4ivqlsgt 124 12 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 124 13 in in IN cord-345211-4ivqlsgt 124 14 pleural pleural JJ cord-345211-4ivqlsgt 124 15 fluid fluid NN cord-345211-4ivqlsgt 124 16 [ [ -LRB- cord-345211-4ivqlsgt 124 17 68 68 CD cord-345211-4ivqlsgt 124 18 , , , cord-345211-4ivqlsgt 124 19 69 69 CD cord-345211-4ivqlsgt 124 20 ] ] -RRB- cord-345211-4ivqlsgt 124 21 . . . cord-345211-4ivqlsgt 125 1 Another another DT cord-345211-4ivqlsgt 125 2 important important JJ cord-345211-4ivqlsgt 125 3 limitation limitation NN cord-345211-4ivqlsgt 125 4 with with IN cord-345211-4ivqlsgt 125 5 current current JJ cord-345211-4ivqlsgt 125 6 NATs NATs NNP cord-345211-4ivqlsgt 125 7 is be VBZ cord-345211-4ivqlsgt 125 8 their -PRON- PRP$ cord-345211-4ivqlsgt 125 9 focus focus NN cord-345211-4ivqlsgt 125 10 , , , cord-345211-4ivqlsgt 125 11 by by IN cord-345211-4ivqlsgt 125 12 nature nature NN cord-345211-4ivqlsgt 125 13 , , , cord-345211-4ivqlsgt 125 14 on on IN cord-345211-4ivqlsgt 125 15 specific specific JJ cord-345211-4ivqlsgt 125 16 known know VBN cord-345211-4ivqlsgt 125 17 or or CC cord-345211-4ivqlsgt 125 18 suspected suspect VBN cord-345211-4ivqlsgt 125 19 pneumonia pneumonia NN cord-345211-4ivqlsgt 125 20 pathogens pathogen NNS cord-345211-4ivqlsgt 125 21 . . . cord-345211-4ivqlsgt 126 1 Implicit implicit JJ cord-345211-4ivqlsgt 126 2 with with IN cord-345211-4ivqlsgt 126 3 this this DT cord-345211-4ivqlsgt 126 4 focus focus NN cord-345211-4ivqlsgt 126 5 is be VBZ cord-345211-4ivqlsgt 126 6 the the DT cord-345211-4ivqlsgt 126 7 assumption assumption NN cord-345211-4ivqlsgt 126 8 that that IN cord-345211-4ivqlsgt 126 9 we -PRON- PRP cord-345211-4ivqlsgt 126 10 know know VBP cord-345211-4ivqlsgt 126 11 the the DT cord-345211-4ivqlsgt 126 12 full full JJ cord-345211-4ivqlsgt 126 13 range range NN cord-345211-4ivqlsgt 126 14 of of IN cord-345211-4ivqlsgt 126 15 key key JJ cord-345211-4ivqlsgt 126 16 potential potential JJ cord-345211-4ivqlsgt 126 17 pathogens pathogen NNS cord-345211-4ivqlsgt 126 18 that that WDT cord-345211-4ivqlsgt 126 19 cause cause VBP cord-345211-4ivqlsgt 126 20 pneumonia pneumonia NN cord-345211-4ivqlsgt 126 21 . . . cord-345211-4ivqlsgt 127 1 This this DT cord-345211-4ivqlsgt 127 2 may may MD cord-345211-4ivqlsgt 127 3 well well RB cord-345211-4ivqlsgt 127 4 be be VB cord-345211-4ivqlsgt 127 5 correct correct JJ cord-345211-4ivqlsgt 127 6 , , , cord-345211-4ivqlsgt 127 7 but but CC cord-345211-4ivqlsgt 127 8 there there EX cord-345211-4ivqlsgt 127 9 is be VBZ cord-345211-4ivqlsgt 127 10 increasing increase VBG cord-345211-4ivqlsgt 127 11 interest interest NN cord-345211-4ivqlsgt 127 12 in in IN cord-345211-4ivqlsgt 127 13 the the DT cord-345211-4ivqlsgt 127 14 use use NN cord-345211-4ivqlsgt 127 15 of of IN cord-345211-4ivqlsgt 127 16 modern modern JJ cord-345211-4ivqlsgt 127 17 techniques technique NNS cord-345211-4ivqlsgt 127 18 , , , cord-345211-4ivqlsgt 127 19 such such JJ cord-345211-4ivqlsgt 127 20 as as IN cord-345211-4ivqlsgt 127 21 next next JJ cord-345211-4ivqlsgt 127 22 generation generation NN cord-345211-4ivqlsgt 127 23 sequencing sequencing NN cord-345211-4ivqlsgt 127 24 , , , cord-345211-4ivqlsgt 127 25 which which WDT cord-345211-4ivqlsgt 127 26 provide provide VBP cord-345211-4ivqlsgt 127 27 the the DT cord-345211-4ivqlsgt 127 28 opportunity opportunity NN cord-345211-4ivqlsgt 127 29 for for IN cord-345211-4ivqlsgt 127 30 discovering discover VBG cord-345211-4ivqlsgt 127 31 new new JJ cord-345211-4ivqlsgt 127 32 or or CC cord-345211-4ivqlsgt 127 33 unexpected unexpected JJ cord-345211-4ivqlsgt 127 34 pathogens pathogen NNS cord-345211-4ivqlsgt 127 35 [ [ -LRB- cord-345211-4ivqlsgt 127 36 70 70 CD cord-345211-4ivqlsgt 127 37 , , , cord-345211-4ivqlsgt 127 38 71 71 CD cord-345211-4ivqlsgt 127 39 ] ] -RRB- cord-345211-4ivqlsgt 127 40 . . . cord-345211-4ivqlsgt 128 1 The the DT cord-345211-4ivqlsgt 128 2 broader broad JJR cord-345211-4ivqlsgt 128 3 approach approach NN cord-345211-4ivqlsgt 128 4 of of IN cord-345211-4ivqlsgt 128 5 these these DT cord-345211-4ivqlsgt 128 6 technologies technology NNS cord-345211-4ivqlsgt 128 7 may may MD cord-345211-4ivqlsgt 128 8 provide provide VB cord-345211-4ivqlsgt 128 9 novel novel JJ cord-345211-4ivqlsgt 128 10 insights insight NNS cord-345211-4ivqlsgt 128 11 into into IN cord-345211-4ivqlsgt 128 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 128 13 etiology etiology NN cord-345211-4ivqlsgt 128 14 , , , cord-345211-4ivqlsgt 128 15 but but CC cord-345211-4ivqlsgt 128 16 have have VBP cord-345211-4ivqlsgt 128 17 yet yet RB cord-345211-4ivqlsgt 128 18 to to TO cord-345211-4ivqlsgt 128 19 show show VB cord-345211-4ivqlsgt 128 20 added add VBN cord-345211-4ivqlsgt 128 21 advantage advantage NN cord-345211-4ivqlsgt 128 22 as as IN cord-345211-4ivqlsgt 128 23 a a DT cord-345211-4ivqlsgt 128 24 routine routine JJ cord-345211-4ivqlsgt 128 25 diagnostic diagnostic JJ cord-345211-4ivqlsgt 128 26 tool tool NN cord-345211-4ivqlsgt 128 27 [ [ -LRB- cord-345211-4ivqlsgt 128 28 72 72 CD cord-345211-4ivqlsgt 128 29 ] ] -RRB- cord-345211-4ivqlsgt 128 30 . . . cord-345211-4ivqlsgt 129 1 No no DT cord-345211-4ivqlsgt 129 2 major major JJ cord-345211-4ivqlsgt 129 3 new new JJ cord-345211-4ivqlsgt 129 4 pneumonia pneumonia NN cord-345211-4ivqlsgt 129 5 pathogens pathogen NNS cord-345211-4ivqlsgt 129 6 have have VBP cord-345211-4ivqlsgt 129 7 been be VBN cord-345211-4ivqlsgt 129 8 uncovered uncover VBN cord-345211-4ivqlsgt 129 9 over over IN cord-345211-4ivqlsgt 129 10 recent recent JJ cord-345211-4ivqlsgt 129 11 years year NNS cord-345211-4ivqlsgt 129 12 . . . cord-345211-4ivqlsgt 130 1 A a DT cord-345211-4ivqlsgt 130 2 key key JJ cord-345211-4ivqlsgt 130 3 reason reason NN cord-345211-4ivqlsgt 130 4 for for IN cord-345211-4ivqlsgt 130 5 the the DT cord-345211-4ivqlsgt 130 6 slow slow JJ cord-345211-4ivqlsgt 130 7 adoption adoption NN cord-345211-4ivqlsgt 130 8 of of IN cord-345211-4ivqlsgt 130 9 respiratory respiratory JJ cord-345211-4ivqlsgt 130 10 NATs nat NNS cord-345211-4ivqlsgt 130 11 by by IN cord-345211-4ivqlsgt 130 12 diagnostic diagnostic JJ cord-345211-4ivqlsgt 130 13 laboratories laboratory NNS cord-345211-4ivqlsgt 130 14 is be VBZ cord-345211-4ivqlsgt 130 15 the the DT cord-345211-4ivqlsgt 130 16 lack lack NN cord-345211-4ivqlsgt 130 17 of of IN cord-345211-4ivqlsgt 130 18 commercial commercial JJ cord-345211-4ivqlsgt 130 19 assays assay NNS cord-345211-4ivqlsgt 130 20 that that WDT cord-345211-4ivqlsgt 130 21 have have VBP cord-345211-4ivqlsgt 130 22 been be VBN cord-345211-4ivqlsgt 130 23 approved approve VBN cord-345211-4ivqlsgt 130 24 by by IN cord-345211-4ivqlsgt 130 25 regulatory regulatory JJ cord-345211-4ivqlsgt 130 26 bodies body NNS cord-345211-4ivqlsgt 130 27 . . . cord-345211-4ivqlsgt 131 1 The the DT cord-345211-4ivqlsgt 131 2 impact impact NN cord-345211-4ivqlsgt 131 3 has have VBZ cord-345211-4ivqlsgt 131 4 probably probably RB cord-345211-4ivqlsgt 131 5 been be VBN cord-345211-4ivqlsgt 131 6 felt feel VBN cord-345211-4ivqlsgt 131 7 more more JJR cord-345211-4ivqlsgt 131 8 in in IN cord-345211-4ivqlsgt 131 9 the the DT cord-345211-4ivqlsgt 131 10 USA USA NNP cord-345211-4ivqlsgt 131 11 given give VBD cord-345211-4ivqlsgt 131 12 the the DT cord-345211-4ivqlsgt 131 13 strict strict JJ cord-345211-4ivqlsgt 131 14 requirements requirement NNS cord-345211-4ivqlsgt 131 15 of of IN cord-345211-4ivqlsgt 131 16 the the DT cord-345211-4ivqlsgt 131 17 US US NNP cord-345211-4ivqlsgt 131 18 FDA FDA NNP cord-345211-4ivqlsgt 131 19 . . . cord-345211-4ivqlsgt 132 1 The the DT cord-345211-4ivqlsgt 132 2 level level NN cord-345211-4ivqlsgt 132 3 and and CC cord-345211-4ivqlsgt 132 4 importance importance NN cord-345211-4ivqlsgt 132 5 of of IN cord-345211-4ivqlsgt 132 6 regulation regulation NN cord-345211-4ivqlsgt 132 7 have have VBP cord-345211-4ivqlsgt 132 8 been be VBN cord-345211-4ivqlsgt 132 9 debated debate VBN cord-345211-4ivqlsgt 132 10 [ [ -LRB- cord-345211-4ivqlsgt 132 11 73 73 CD cord-345211-4ivqlsgt 132 12 , , , cord-345211-4ivqlsgt 132 13 74 74 CD cord-345211-4ivqlsgt 132 14 ] ] -RRB- cord-345211-4ivqlsgt 132 15 , , , cord-345211-4ivqlsgt 132 16 and and CC cord-345211-4ivqlsgt 132 17 it -PRON- PRP cord-345211-4ivqlsgt 132 18 is be VBZ cord-345211-4ivqlsgt 132 19 clear clear JJ cord-345211-4ivqlsgt 132 20 that that IN cord-345211-4ivqlsgt 132 21 a a DT cord-345211-4ivqlsgt 132 22 balance balance NN cord-345211-4ivqlsgt 132 23 is be VBZ cord-345211-4ivqlsgt 132 24 needed need VBN cord-345211-4ivqlsgt 132 25 between between IN cord-345211-4ivqlsgt 132 26 appropriate appropriate JJ cord-345211-4ivqlsgt 132 27 regulation regulation NN cord-345211-4ivqlsgt 132 28 of of IN cord-345211-4ivqlsgt 132 29 new new JJ cord-345211-4ivqlsgt 132 30 diagnostics diagnostic NNS cord-345211-4ivqlsgt 132 31 , , , cord-345211-4ivqlsgt 132 32 while while IN cord-345211-4ivqlsgt 132 33 avoiding avoid VBG cord-345211-4ivqlsgt 132 34 unnecessary unnecessary JJ cord-345211-4ivqlsgt 132 35 barriers barrier NNS cord-345211-4ivqlsgt 132 36 to to IN cord-345211-4ivqlsgt 132 37 the the DT cord-345211-4ivqlsgt 132 38 deployment deployment NN cord-345211-4ivqlsgt 132 39 of of IN cord-345211-4ivqlsgt 132 40 useful useful JJ cord-345211-4ivqlsgt 132 41 tests test NNS cord-345211-4ivqlsgt 132 42 . . . cord-345211-4ivqlsgt 133 1 The the DT cord-345211-4ivqlsgt 133 2 use use NN cord-345211-4ivqlsgt 133 3 of of IN cord-345211-4ivqlsgt 133 4 molecular molecular JJ cord-345211-4ivqlsgt 133 5 tests test NNS cord-345211-4ivqlsgt 133 6 for for IN cord-345211-4ivqlsgt 133 7 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 133 8 ' ' POS cord-345211-4ivqlsgt 133 9 disease disease NN cord-345211-4ivqlsgt 133 10 is be VBZ cord-345211-4ivqlsgt 133 11 a a DT cord-345211-4ivqlsgt 133 12 good good JJ cord-345211-4ivqlsgt 133 13 example example NN cord-345211-4ivqlsgt 133 14 of of IN cord-345211-4ivqlsgt 133 15 how how WRB cord-345211-4ivqlsgt 133 16 assay assay NN cord-345211-4ivqlsgt 133 17 regulation regulation NN cord-345211-4ivqlsgt 133 18 has have VBZ cord-345211-4ivqlsgt 133 19 had have VBN cord-345211-4ivqlsgt 133 20 an an DT cord-345211-4ivqlsgt 133 21 impact impact NN cord-345211-4ivqlsgt 133 22 on on IN cord-345211-4ivqlsgt 133 23 diagnostic diagnostic JJ cord-345211-4ivqlsgt 133 24 strategies strategy NNS cord-345211-4ivqlsgt 133 25 . . . cord-345211-4ivqlsgt 134 1 Despite despite IN cord-345211-4ivqlsgt 134 2 NATs nat NNS cord-345211-4ivqlsgt 134 3 being be VBG cord-345211-4ivqlsgt 134 4 the the DT cord-345211-4ivqlsgt 134 5 diagnostic diagnostic JJ cord-345211-4ivqlsgt 134 6 test test NN cord-345211-4ivqlsgt 134 7 of of IN cord-345211-4ivqlsgt 134 8 choice choice NN cord-345211-4ivqlsgt 134 9 for for IN cord-345211-4ivqlsgt 134 10 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 134 11 ' ' POS cord-345211-4ivqlsgt 134 12 disease disease NN cord-345211-4ivqlsgt 134 13 , , , cord-345211-4ivqlsgt 134 14 the the DT cord-345211-4ivqlsgt 134 15 shortage shortage NN cord-345211-4ivqlsgt 134 16 of of IN cord-345211-4ivqlsgt 134 17 FDA FDA NNP cord-345211-4ivqlsgt 134 18 - - HYPH cord-345211-4ivqlsgt 134 19 approved approve VBN cord-345211-4ivqlsgt 134 20 assays assay NNS cord-345211-4ivqlsgt 134 21 has have VBZ cord-345211-4ivqlsgt 134 22 severely severely RB cord-345211-4ivqlsgt 134 23 limited limit VBN cord-345211-4ivqlsgt 134 24 the the DT cord-345211-4ivqlsgt 134 25 use use NN cord-345211-4ivqlsgt 134 26 of of IN cord-345211-4ivqlsgt 134 27 these these DT cord-345211-4ivqlsgt 134 28 tests test NNS cord-345211-4ivqlsgt 134 29 in in IN cord-345211-4ivqlsgt 134 30 the the DT cord-345211-4ivqlsgt 134 31 USA USA NNP cord-345211-4ivqlsgt 134 32 , , , cord-345211-4ivqlsgt 134 33 resulting result VBG cord-345211-4ivqlsgt 134 34 in in IN cord-345211-4ivqlsgt 134 35 the the DT cord-345211-4ivqlsgt 134 36 continued continue VBN cord-345211-4ivqlsgt 134 37 use use NN cord-345211-4ivqlsgt 134 38 of of IN cord-345211-4ivqlsgt 134 39 suboptimal suboptimal JJ cord-345211-4ivqlsgt 134 40 diagnostics diagnostic NNS cord-345211-4ivqlsgt 134 41 and and CC cord-345211-4ivqlsgt 134 42 underdiagnosis underdiagnosis NN cord-345211-4ivqlsgt 134 43 of of IN cord-345211-4ivqlsgt 134 44 this this DT cord-345211-4ivqlsgt 134 45 disease disease NN cord-345211-4ivqlsgt 134 46 [ [ -LRB- cord-345211-4ivqlsgt 134 47 27 27 CD cord-345211-4ivqlsgt 134 48 ] ] -RRB- cord-345211-4ivqlsgt 134 49 . . . cord-345211-4ivqlsgt 135 1 Moreover moreover RB cord-345211-4ivqlsgt 135 2 , , , cord-345211-4ivqlsgt 135 3 the the DT cord-345211-4ivqlsgt 135 4 absence absence NN cord-345211-4ivqlsgt 135 5 of of IN cord-345211-4ivqlsgt 135 6 a a DT cord-345211-4ivqlsgt 135 7 prominent prominent JJ cord-345211-4ivqlsgt 135 8 role role NN cord-345211-4ivqlsgt 135 9 in in IN cord-345211-4ivqlsgt 135 10 diagnostic diagnostic JJ cord-345211-4ivqlsgt 135 11 algorithms algorithm NNS cord-345211-4ivqlsgt 135 12 has have VBZ cord-345211-4ivqlsgt 135 13 possibly possibly RB cord-345211-4ivqlsgt 135 14 led lead VBN cord-345211-4ivqlsgt 135 15 to to IN cord-345211-4ivqlsgt 135 16 an an DT cord-345211-4ivqlsgt 135 17 incorrect incorrect JJ cord-345211-4ivqlsgt 135 18 perception perception NN cord-345211-4ivqlsgt 135 19 that that IN cord-345211-4ivqlsgt 135 20 the the DT cord-345211-4ivqlsgt 135 21 performance performance NN cord-345211-4ivqlsgt 135 22 of of IN cord-345211-4ivqlsgt 135 23 NATs NATs NNP cord-345211-4ivqlsgt 135 24 is be VBZ cord-345211-4ivqlsgt 135 25 inadequate inadequate JJ cord-345211-4ivqlsgt 135 26 . . . cord-345211-4ivqlsgt 136 1 Hopefully hopefully RB cord-345211-4ivqlsgt 136 2 , , , cord-345211-4ivqlsgt 136 3 increased increase VBN cord-345211-4ivqlsgt 136 4 experience experience NN cord-345211-4ivqlsgt 136 5 with with IN cord-345211-4ivqlsgt 136 6 these these DT cord-345211-4ivqlsgt 136 7 tests test NNS cord-345211-4ivqlsgt 136 8 will will MD cord-345211-4ivqlsgt 136 9 reverse reverse VB cord-345211-4ivqlsgt 136 10 this this DT cord-345211-4ivqlsgt 136 11 perception perception NN cord-345211-4ivqlsgt 136 12 . . . cord-345211-4ivqlsgt 137 1 A a DT cord-345211-4ivqlsgt 137 2 major major JJ cord-345211-4ivqlsgt 137 3 recent recent JJ cord-345211-4ivqlsgt 137 4 revelation revelation NN cord-345211-4ivqlsgt 137 5 in in IN cord-345211-4ivqlsgt 137 6 respiratory respiratory JJ cord-345211-4ivqlsgt 137 7 medicine medicine NN cord-345211-4ivqlsgt 137 8 has have VBZ cord-345211-4ivqlsgt 137 9 been be VBN cord-345211-4ivqlsgt 137 10 recognition recognition NN cord-345211-4ivqlsgt 137 11 of of IN cord-345211-4ivqlsgt 137 12 the the DT cord-345211-4ivqlsgt 137 13 lung lung NN cord-345211-4ivqlsgt 137 14 microbiome microbiome NN cord-345211-4ivqlsgt 137 15 [ [ -LRB- cord-345211-4ivqlsgt 137 16 75 75 CD cord-345211-4ivqlsgt 137 17 ] ] -RRB- cord-345211-4ivqlsgt 137 18 . . . cord-345211-4ivqlsgt 138 1 Until until IN cord-345211-4ivqlsgt 138 2 recently recently RB cord-345211-4ivqlsgt 138 3 , , , cord-345211-4ivqlsgt 138 4 the the DT cord-345211-4ivqlsgt 138 5 lungs lung NNS cord-345211-4ivqlsgt 138 6 in in IN cord-345211-4ivqlsgt 138 7 health health NN cord-345211-4ivqlsgt 138 8 were be VBD cord-345211-4ivqlsgt 138 9 regarded regard VBN cord-345211-4ivqlsgt 138 10 as as IN cord-345211-4ivqlsgt 138 11 sterile sterile JJ cord-345211-4ivqlsgt 138 12 . . . cord-345211-4ivqlsgt 139 1 The the DT cord-345211-4ivqlsgt 139 2 use use NN cord-345211-4ivqlsgt 139 3 of of IN cord-345211-4ivqlsgt 139 4 modern modern JJ cord-345211-4ivqlsgt 139 5 culture culture NN cord-345211-4ivqlsgt 139 6 - - HYPH cord-345211-4ivqlsgt 139 7 independent independent JJ cord-345211-4ivqlsgt 139 8 techniques technique NNS cord-345211-4ivqlsgt 139 9 has have VBZ cord-345211-4ivqlsgt 139 10 not not RB cord-345211-4ivqlsgt 139 11 supported support VBN cord-345211-4ivqlsgt 139 12 this this DT cord-345211-4ivqlsgt 139 13 concept concept NN cord-345211-4ivqlsgt 139 14 , , , cord-345211-4ivqlsgt 139 15 consistently consistently RB cord-345211-4ivqlsgt 139 16 finding find VBG cord-345211-4ivqlsgt 139 17 evidence evidence NN cord-345211-4ivqlsgt 139 18 of of IN cord-345211-4ivqlsgt 139 19 bacteria bacteria NNS cord-345211-4ivqlsgt 139 20 in in IN cord-345211-4ivqlsgt 139 21 the the DT cord-345211-4ivqlsgt 139 22 lower low JJR cord-345211-4ivqlsgt 139 23 airways airway NNS cord-345211-4ivqlsgt 139 24 [ [ -LRB- cord-345211-4ivqlsgt 139 25 75 75 CD cord-345211-4ivqlsgt 139 26 ] ] -RRB- cord-345211-4ivqlsgt 139 27 . . . cord-345211-4ivqlsgt 140 1 This this DT cord-345211-4ivqlsgt 140 2 important important JJ cord-345211-4ivqlsgt 140 3 realization realization NN cord-345211-4ivqlsgt 140 4 has have VBZ cord-345211-4ivqlsgt 140 5 challenged challenge VBN cord-345211-4ivqlsgt 140 6 our -PRON- PRP$ cord-345211-4ivqlsgt 140 7 traditional traditional JJ cord-345211-4ivqlsgt 140 8 paradigm paradigm NN cord-345211-4ivqlsgt 140 9 of of IN cord-345211-4ivqlsgt 140 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 140 11 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 140 12 . . . cord-345211-4ivqlsgt 141 1 The the DT cord-345211-4ivqlsgt 141 2 tradition tradition NN cord-345211-4ivqlsgt 141 3 view view VBP cord-345211-4ivqlsgt 141 4 that that IN cord-345211-4ivqlsgt 141 5 pneumonia pneumonia NN cord-345211-4ivqlsgt 141 6 is be VBZ cord-345211-4ivqlsgt 141 7 caused cause VBN cord-345211-4ivqlsgt 141 8 by by IN cord-345211-4ivqlsgt 141 9 a a DT cord-345211-4ivqlsgt 141 10 single single JJ cord-345211-4ivqlsgt 141 11 invasive invasive JJ cord-345211-4ivqlsgt 141 12 pathogen pathogen NN cord-345211-4ivqlsgt 141 13 in in IN cord-345211-4ivqlsgt 141 14 a a DT cord-345211-4ivqlsgt 141 15 normally normally RB cord-345211-4ivqlsgt 141 16 sterile sterile JJ cord-345211-4ivqlsgt 141 17 site site NN cord-345211-4ivqlsgt 141 18 is be VBZ cord-345211-4ivqlsgt 141 19 likely likely RB cord-345211-4ivqlsgt 141 20 wrong wrong JJ cord-345211-4ivqlsgt 141 21 . . . cord-345211-4ivqlsgt 142 1 Increasing increase VBG cord-345211-4ivqlsgt 142 2 recognition recognition NN cord-345211-4ivqlsgt 142 3 that that IN cord-345211-4ivqlsgt 142 4 bacteria bacteria NNS cord-345211-4ivqlsgt 142 5 and and CC cord-345211-4ivqlsgt 142 6 viruses virus NNS cord-345211-4ivqlsgt 142 7 frequently frequently RB cord-345211-4ivqlsgt 142 8 interact interact VBP cord-345211-4ivqlsgt 142 9 in in IN cord-345211-4ivqlsgt 142 10 the the DT cord-345211-4ivqlsgt 142 11 causative causative JJ cord-345211-4ivqlsgt 142 12 pathway pathway NN cord-345211-4ivqlsgt 142 13 to to IN cord-345211-4ivqlsgt 142 14 pneumonia pneumonia NN cord-345211-4ivqlsgt 142 15 [ [ -LRB- cord-345211-4ivqlsgt 142 16 76 76 CD cord-345211-4ivqlsgt 142 17 , , , cord-345211-4ivqlsgt 142 18 77 77 CD cord-345211-4ivqlsgt 142 19 ] ] -RRB- cord-345211-4ivqlsgt 142 20 adds add VBZ cord-345211-4ivqlsgt 142 21 additional additional JJ cord-345211-4ivqlsgt 142 22 complexity complexity NN cord-345211-4ivqlsgt 142 23 , , , cord-345211-4ivqlsgt 142 24 as as IN cord-345211-4ivqlsgt 142 25 does do VBZ cord-345211-4ivqlsgt 142 26 the the DT cord-345211-4ivqlsgt 142 27 frequent frequent JJ cord-345211-4ivqlsgt 142 28 finding finding NN cord-345211-4ivqlsgt 142 29 of of IN cord-345211-4ivqlsgt 142 30 polymicrobial polymicrobial JJ cord-345211-4ivqlsgt 142 31 infections infection NNS cord-345211-4ivqlsgt 142 32 [ [ -LRB- cord-345211-4ivqlsgt 142 33 78 78 CD cord-345211-4ivqlsgt 142 34 ] ] -RRB- cord-345211-4ivqlsgt 142 35 . . . cord-345211-4ivqlsgt 143 1 Under under IN cord-345211-4ivqlsgt 143 2 the the DT cord-345211-4ivqlsgt 143 3 new new JJ cord-345211-4ivqlsgt 143 4 paradigm paradigm NN cord-345211-4ivqlsgt 143 5 , , , cord-345211-4ivqlsgt 143 6 dominant dominant JJ cord-345211-4ivqlsgt 143 7 species specie NNS cord-345211-4ivqlsgt 143 8 emerge emerge VBP cord-345211-4ivqlsgt 143 9 from from IN cord-345211-4ivqlsgt 143 10 the the DT cord-345211-4ivqlsgt 143 11 lung lung NN cord-345211-4ivqlsgt 143 12 ecosystem ecosystem NN cord-345211-4ivqlsgt 143 13 in in IN cord-345211-4ivqlsgt 143 14 pneumonia pneumonia NN cord-345211-4ivqlsgt 143 15 through through IN cord-345211-4ivqlsgt 143 16 uncertain uncertain JJ cord-345211-4ivqlsgt 143 17 mechanisms mechanism NNS cord-345211-4ivqlsgt 143 18 , , , cord-345211-4ivqlsgt 143 19 and and CC cord-345211-4ivqlsgt 143 20 the the DT cord-345211-4ivqlsgt 143 21 bacterial bacterial JJ cord-345211-4ivqlsgt 143 22 versus versus IN cord-345211-4ivqlsgt 143 23 viral viral JJ cord-345211-4ivqlsgt 143 24 pneumonia pneumonia NN cord-345211-4ivqlsgt 143 25 concept concept NN cord-345211-4ivqlsgt 143 26 is be VBZ cord-345211-4ivqlsgt 143 27 too too RB cord-345211-4ivqlsgt 143 28 simplistic simplistic JJ cord-345211-4ivqlsgt 143 29 . . . cord-345211-4ivqlsgt 144 1 Consequently consequently RB cord-345211-4ivqlsgt 144 2 , , , cord-345211-4ivqlsgt 144 3 we -PRON- PRP cord-345211-4ivqlsgt 144 4 probably probably RB cord-345211-4ivqlsgt 144 5 need need VBP cord-345211-4ivqlsgt 144 6 to to TO cord-345211-4ivqlsgt 144 7 use use VB cord-345211-4ivqlsgt 144 8 more more RBR cord-345211-4ivqlsgt 144 9 sophisticated sophisticated JJ cord-345211-4ivqlsgt 144 10 approaches approach NNS cord-345211-4ivqlsgt 144 11 to to IN cord-345211-4ivqlsgt 144 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 144 13 diagnosis diagnosis NN cord-345211-4ivqlsgt 144 14 than than IN cord-345211-4ivqlsgt 144 15 assays assay NNS cord-345211-4ivqlsgt 144 16 that that WDT cord-345211-4ivqlsgt 144 17 simply simply RB cord-345211-4ivqlsgt 144 18 target target VBP cord-345211-4ivqlsgt 144 19 single single JJ cord-345211-4ivqlsgt 144 20 specific specific JJ cord-345211-4ivqlsgt 144 21 putative putative JJ cord-345211-4ivqlsgt 144 22 pathogens pathogen NNS cord-345211-4ivqlsgt 144 23 . . . cord-345211-4ivqlsgt 145 1 We -PRON- PRP cord-345211-4ivqlsgt 145 2 have have VBP cord-345211-4ivqlsgt 145 3 a a DT cord-345211-4ivqlsgt 145 4 lot lot NN cord-345211-4ivqlsgt 145 5 to to TO cord-345211-4ivqlsgt 145 6 learn learn VB cord-345211-4ivqlsgt 145 7 and and CC cord-345211-4ivqlsgt 145 8 are be VBP cord-345211-4ivqlsgt 145 9 only only RB cord-345211-4ivqlsgt 145 10 just just RB cord-345211-4ivqlsgt 145 11 beginning begin VBG cord-345211-4ivqlsgt 145 12 to to TO cord-345211-4ivqlsgt 145 13 understand understand VB cord-345211-4ivqlsgt 145 14 changes change NNS cord-345211-4ivqlsgt 145 15 in in IN cord-345211-4ivqlsgt 145 16 the the DT cord-345211-4ivqlsgt 145 17 microbiome microbiome NN cord-345211-4ivqlsgt 145 18 during during IN cord-345211-4ivqlsgt 145 19 acute acute JJ cord-345211-4ivqlsgt 145 20 infections infection NNS cord-345211-4ivqlsgt 145 21 [ [ -LRB- cord-345211-4ivqlsgt 145 22 75 75 CD cord-345211-4ivqlsgt 145 23 , , , cord-345211-4ivqlsgt 145 24 79 79 CD cord-345211-4ivqlsgt 145 25 , , , cord-345211-4ivqlsgt 145 26 80 80 CD cord-345211-4ivqlsgt 145 27 ] ] -RRB- cord-345211-4ivqlsgt 145 28 . . . cord-345211-4ivqlsgt 146 1 Analysis analysis NN cord-345211-4ivqlsgt 146 2 of of IN cord-345211-4ivqlsgt 146 3 the the DT cord-345211-4ivqlsgt 146 4 lung lung NN cord-345211-4ivqlsgt 146 5 microbiome microbiome NN cord-345211-4ivqlsgt 146 6 may may MD cord-345211-4ivqlsgt 146 7 provide provide VB cord-345211-4ivqlsgt 146 8 insights insight NNS cord-345211-4ivqlsgt 146 9 into into IN cord-345211-4ivqlsgt 146 10 pneumonia pneumonia NN cord-345211-4ivqlsgt 146 11 etiology etiology NN cord-345211-4ivqlsgt 146 12 and and CC cord-345211-4ivqlsgt 146 13 reveal reveal VB cord-345211-4ivqlsgt 146 14 novel novel JJ cord-345211-4ivqlsgt 146 15 markers marker NNS cord-345211-4ivqlsgt 146 16 for for IN cord-345211-4ivqlsgt 146 17 pneumonia pneumonia NN cord-345211-4ivqlsgt 146 18 prognosis prognosis NN cord-345211-4ivqlsgt 146 19 and and CC cord-345211-4ivqlsgt 146 20 for for IN cord-345211-4ivqlsgt 146 21 treatment treatment NN cord-345211-4ivqlsgt 146 22 guidance guidance NN cord-345211-4ivqlsgt 146 23 [ [ -LRB- cord-345211-4ivqlsgt 146 24 81 81 CD cord-345211-4ivqlsgt 146 25 ] ] -RRB- cord-345211-4ivqlsgt 146 26 . . . cord-345211-4ivqlsgt 147 1 Molecular molecular JJ cord-345211-4ivqlsgt 147 2 diagnostic diagnostic JJ cord-345211-4ivqlsgt 147 3 techniques technique NNS cord-345211-4ivqlsgt 147 4 clearly clearly RB cord-345211-4ivqlsgt 147 5 have have VBP cord-345211-4ivqlsgt 147 6 a a DT cord-345211-4ivqlsgt 147 7 central central JJ cord-345211-4ivqlsgt 147 8 role role NN cord-345211-4ivqlsgt 147 9 in in IN cord-345211-4ivqlsgt 147 10 these these DT cord-345211-4ivqlsgt 147 11 metagenomic metagenomic NN cord-345211-4ivqlsgt 147 12 analyses analysis NNS cord-345211-4ivqlsgt 147 13 [ [ -LRB- cord-345211-4ivqlsgt 147 14 82 82 CD cord-345211-4ivqlsgt 147 15 , , , cord-345211-4ivqlsgt 147 16 83 83 CD cord-345211-4ivqlsgt 147 17 ] ] -RRB- cord-345211-4ivqlsgt 147 18 , , , cord-345211-4ivqlsgt 147 19 providing provide VBG cord-345211-4ivqlsgt 147 20 another another DT cord-345211-4ivqlsgt 147 21 opportunity opportunity NN cord-345211-4ivqlsgt 147 22 for for IN cord-345211-4ivqlsgt 147 23 next next JJ cord-345211-4ivqlsgt 147 24 generation generation NN cord-345211-4ivqlsgt 147 25 sequencing sequencing NN cord-345211-4ivqlsgt 147 26 technology technology NN cord-345211-4ivqlsgt 147 27 . . . cord-345211-4ivqlsgt 148 1 Any any DT cord-345211-4ivqlsgt 148 2 future future JJ cord-345211-4ivqlsgt 148 3 developments development NNS cord-345211-4ivqlsgt 148 4 in in IN cord-345211-4ivqlsgt 148 5 pneumonia pneumonia NN cord-345211-4ivqlsgt 148 6 diagnostics diagnostic NNS cord-345211-4ivqlsgt 148 7 must must MD cord-345211-4ivqlsgt 148 8 be be VB cord-345211-4ivqlsgt 148 9 cognizant cognizant JJ cord-345211-4ivqlsgt 148 10 of of IN cord-345211-4ivqlsgt 148 11 new new JJ cord-345211-4ivqlsgt 148 12 knowledge knowledge NN cord-345211-4ivqlsgt 148 13 about about IN cord-345211-4ivqlsgt 148 14 the the DT cord-345211-4ivqlsgt 148 15 lung lung NN cord-345211-4ivqlsgt 148 16 microbiome microbiome NN cord-345211-4ivqlsgt 148 17 and and CC cord-345211-4ivqlsgt 148 18 about about IN cord-345211-4ivqlsgt 148 19 changes change NNS cord-345211-4ivqlsgt 148 20 in in IN cord-345211-4ivqlsgt 148 21 the the DT cord-345211-4ivqlsgt 148 22 lungs lung NNS cord-345211-4ivqlsgt 148 23 during during IN cord-345211-4ivqlsgt 148 24 the the DT cord-345211-4ivqlsgt 148 25 pathway pathway NN cord-345211-4ivqlsgt 148 26 to to IN cord-345211-4ivqlsgt 148 27 pneumonia pneumonia NN cord-345211-4ivqlsgt 148 28 . . . cord-345211-4ivqlsgt 149 1 There there EX cord-345211-4ivqlsgt 149 2 is be VBZ cord-345211-4ivqlsgt 149 3 likely likely JJ cord-345211-4ivqlsgt 149 4 to to TO cord-345211-4ivqlsgt 149 5 be be VB cord-345211-4ivqlsgt 149 6 less less JJR cord-345211-4ivqlsgt 149 7 focus focus NN cord-345211-4ivqlsgt 149 8 on on IN cord-345211-4ivqlsgt 149 9 just just RB cord-345211-4ivqlsgt 149 10 the the DT cord-345211-4ivqlsgt 149 11 detection detection NN cord-345211-4ivqlsgt 149 12 of of IN cord-345211-4ivqlsgt 149 13 specific specific JJ cord-345211-4ivqlsgt 149 14 known know VBN cord-345211-4ivqlsgt 149 15 pathogens pathogen NNS cord-345211-4ivqlsgt 149 16 , , , cord-345211-4ivqlsgt 149 17 with with IN cord-345211-4ivqlsgt 149 18 more more JJR cord-345211-4ivqlsgt 149 19 interest interest NN cord-345211-4ivqlsgt 149 20 in in IN cord-345211-4ivqlsgt 149 21 the the DT cord-345211-4ivqlsgt 149 22 search search NN cord-345211-4ivqlsgt 149 23 for for IN cord-345211-4ivqlsgt 149 24 markers marker NNS cord-345211-4ivqlsgt 149 25 of of IN cord-345211-4ivqlsgt 149 26 change change NN cord-345211-4ivqlsgt 149 27 in in IN cord-345211-4ivqlsgt 149 28 the the DT cord-345211-4ivqlsgt 149 29 lung lung NN cord-345211-4ivqlsgt 149 30 microbial microbial NN cord-345211-4ivqlsgt 149 31 ecology ecology NN cord-345211-4ivqlsgt 149 32 in in IN cord-345211-4ivqlsgt 149 33 the the DT cord-345211-4ivqlsgt 149 34 diseased diseased JJ cord-345211-4ivqlsgt 149 35 state state NN cord-345211-4ivqlsgt 149 36 . . . cord-345211-4ivqlsgt 150 1 The the DT cord-345211-4ivqlsgt 150 2 potential potential JJ cord-345211-4ivqlsgt 150 3 application application NN cord-345211-4ivqlsgt 150 4 of of IN cord-345211-4ivqlsgt 150 5 metagenomics metagenomic NNS cord-345211-4ivqlsgt 150 6 in in IN cord-345211-4ivqlsgt 150 7 the the DT cord-345211-4ivqlsgt 150 8 diagnostic diagnostic JJ cord-345211-4ivqlsgt 150 9 laboratory laboratory NN cord-345211-4ivqlsgt 150 10 is be VBZ cord-345211-4ivqlsgt 150 11 still still RB cord-345211-4ivqlsgt 150 12 uncertain uncertain JJ cord-345211-4ivqlsgt 150 13 and and CC cord-345211-4ivqlsgt 150 14 will will MD cord-345211-4ivqlsgt 150 15 dependent dependent JJ cord-345211-4ivqlsgt 150 16 on on IN cord-345211-4ivqlsgt 150 17 the the DT cord-345211-4ivqlsgt 150 18 emergence emergence NN cord-345211-4ivqlsgt 150 19 of of IN cord-345211-4ivqlsgt 150 20 improved improved JJ cord-345211-4ivqlsgt 150 21 sequencing sequencing NN cord-345211-4ivqlsgt 150 22 technology technology NN cord-345211-4ivqlsgt 150 23 and and CC cord-345211-4ivqlsgt 150 24 bioinformatics bioinformatics NN cord-345211-4ivqlsgt 150 25 software software NN cord-345211-4ivqlsgt 150 26 . . . cord-345211-4ivqlsgt 151 1 Whole whole JJ cord-345211-4ivqlsgt 151 2 genome genome NN cord-345211-4ivqlsgt 151 3 sequencing sequencing NN cord-345211-4ivqlsgt 151 4 of of IN cord-345211-4ivqlsgt 151 5 bacterial bacterial JJ cord-345211-4ivqlsgt 151 6 isolates isolate NNS cord-345211-4ivqlsgt 151 7 is be VBZ cord-345211-4ivqlsgt 151 8 already already RB cord-345211-4ivqlsgt 151 9 being be VBG cord-345211-4ivqlsgt 151 10 increasingly increasingly RB cord-345211-4ivqlsgt 151 11 used use VBN cord-345211-4ivqlsgt 151 12 for for IN cord-345211-4ivqlsgt 151 13 strain strain NN cord-345211-4ivqlsgt 151 14 characterization characterization NN cord-345211-4ivqlsgt 151 15 and and CC cord-345211-4ivqlsgt 151 16 epidemiological epidemiological JJ cord-345211-4ivqlsgt 151 17 analyses analysis NNS cord-345211-4ivqlsgt 151 18 [ [ -LRB- cord-345211-4ivqlsgt 151 19 84 84 CD cord-345211-4ivqlsgt 151 20 ] ] -RRB- cord-345211-4ivqlsgt 151 21 . . . cord-345211-4ivqlsgt 152 1 For for IN cord-345211-4ivqlsgt 152 2 detection detection NN cord-345211-4ivqlsgt 152 3 of of IN cord-345211-4ivqlsgt 152 4 specific specific JJ cord-345211-4ivqlsgt 152 5 pathogens pathogen NNS cord-345211-4ivqlsgt 152 6 , , , cord-345211-4ivqlsgt 152 7 existing exist VBG cord-345211-4ivqlsgt 152 8 molecular molecular JJ cord-345211-4ivqlsgt 152 9 tests test NNS cord-345211-4ivqlsgt 152 10 can can MD cord-345211-4ivqlsgt 152 11 detect detect VB cord-345211-4ivqlsgt 152 12 very very RB cord-345211-4ivqlsgt 152 13 low low JJ cord-345211-4ivqlsgt 152 14 microbial microbial JJ cord-345211-4ivqlsgt 152 15 loads load NNS cord-345211-4ivqlsgt 152 16 with with IN cord-345211-4ivqlsgt 152 17 high high JJ cord-345211-4ivqlsgt 152 18 analytical analytical JJ cord-345211-4ivqlsgt 152 19 specificity specificity NN cord-345211-4ivqlsgt 152 20 . . . cord-345211-4ivqlsgt 153 1 It -PRON- PRP cord-345211-4ivqlsgt 153 2 is be VBZ cord-345211-4ivqlsgt 153 3 unlikely unlikely JJ cord-345211-4ivqlsgt 153 4 that that IN cord-345211-4ivqlsgt 153 5 further further JJ cord-345211-4ivqlsgt 153 6 test test NN cord-345211-4ivqlsgt 153 7 developments development NNS cord-345211-4ivqlsgt 153 8 will will MD cord-345211-4ivqlsgt 153 9 lead lead VB cord-345211-4ivqlsgt 153 10 to to IN cord-345211-4ivqlsgt 153 11 significantly significantly RB cord-345211-4ivqlsgt 153 12 improved improve VBN cord-345211-4ivqlsgt 153 13 performance performance NN cord-345211-4ivqlsgt 153 14 than than IN cord-345211-4ivqlsgt 153 15 we -PRON- PRP cord-345211-4ivqlsgt 153 16 have have VBP cord-345211-4ivqlsgt 153 17 now now RB cord-345211-4ivqlsgt 153 18 . . . cord-345211-4ivqlsgt 154 1 Indeed indeed RB cord-345211-4ivqlsgt 154 2 , , , cord-345211-4ivqlsgt 154 3 the the DT cord-345211-4ivqlsgt 154 4 interpretation interpretation NN cord-345211-4ivqlsgt 154 5 of of IN cord-345211-4ivqlsgt 154 6 low low JJ cord-345211-4ivqlsgt 154 7 - - HYPH cord-345211-4ivqlsgt 154 8 level level NN cord-345211-4ivqlsgt 154 9 positive positive JJ cord-345211-4ivqlsgt 154 10 results result NNS cord-345211-4ivqlsgt 154 11 from from IN cord-345211-4ivqlsgt 154 12 NATs NATs NNP cord-345211-4ivqlsgt 154 13 already already RB cord-345211-4ivqlsgt 154 14 provides provide VBZ cord-345211-4ivqlsgt 154 15 a a DT cord-345211-4ivqlsgt 154 16 dilemma dilemma NN cord-345211-4ivqlsgt 154 17 for for IN cord-345211-4ivqlsgt 154 18 diagnostic diagnostic JJ cord-345211-4ivqlsgt 154 19 laboratories laboratory NNS cord-345211-4ivqlsgt 154 20 . . . cord-345211-4ivqlsgt 155 1 Instead instead RB cord-345211-4ivqlsgt 155 2 , , , cord-345211-4ivqlsgt 155 3 the the DT cord-345211-4ivqlsgt 155 4 focus focus NN cord-345211-4ivqlsgt 155 5 of of IN cord-345211-4ivqlsgt 155 6 developers developer NNS cord-345211-4ivqlsgt 155 7 should should MD cord-345211-4ivqlsgt 155 8 be be VB cord-345211-4ivqlsgt 155 9 on on IN cord-345211-4ivqlsgt 155 10 making make VBG cord-345211-4ivqlsgt 155 11 test test NN cord-345211-4ivqlsgt 155 12 platforms platform NNS cord-345211-4ivqlsgt 155 13 that that WDT cord-345211-4ivqlsgt 155 14 are be VBP cord-345211-4ivqlsgt 155 15 more more JJR cord-345211-4ivqlsgt 155 16 user user NN cord-345211-4ivqlsgt 155 17 - - HYPH cord-345211-4ivqlsgt 155 18 friendly friendly JJ cord-345211-4ivqlsgt 155 19 and and CC cord-345211-4ivqlsgt 155 20 that that WDT cord-345211-4ivqlsgt 155 21 allow allow VBP cord-345211-4ivqlsgt 155 22 shorter short JJR cord-345211-4ivqlsgt 155 23 turnaround turnaround NN cord-345211-4ivqlsgt 155 24 times time NNS cord-345211-4ivqlsgt 155 25 . . . cord-345211-4ivqlsgt 156 1 We -PRON- PRP cord-345211-4ivqlsgt 156 2 also also RB cord-345211-4ivqlsgt 156 3 need need VBP cord-345211-4ivqlsgt 156 4 to to TO cord-345211-4ivqlsgt 156 5 place place VB cord-345211-4ivqlsgt 156 6 greater great JJR cord-345211-4ivqlsgt 156 7 attention attention NN cord-345211-4ivqlsgt 156 8 on on IN cord-345211-4ivqlsgt 156 9 the the DT cord-345211-4ivqlsgt 156 10 meaningful meaningful JJ cord-345211-4ivqlsgt 156 11 interpretation interpretation NN cord-345211-4ivqlsgt 156 12 of of IN cord-345211-4ivqlsgt 156 13 positive positive JJ cord-345211-4ivqlsgt 156 14 results result NNS cord-345211-4ivqlsgt 156 15 in in IN cord-345211-4ivqlsgt 156 16 order order NN cord-345211-4ivqlsgt 156 17 to to TO cord-345211-4ivqlsgt 156 18 determine determine VB cord-345211-4ivqlsgt 156 19 which which WDT cord-345211-4ivqlsgt 156 20 microorganisms microorganism NNS cord-345211-4ivqlsgt 156 21 are be VBP cord-345211-4ivqlsgt 156 22 actually actually RB cord-345211-4ivqlsgt 156 23 causing cause VBG cord-345211-4ivqlsgt 156 24 individual individual JJ cord-345211-4ivqlsgt 156 25 episodes episode NNS cord-345211-4ivqlsgt 156 26 of of IN cord-345211-4ivqlsgt 156 27 pneumonia pneumonia NN cord-345211-4ivqlsgt 156 28 . . . cord-345211-4ivqlsgt 157 1 One one CD cord-345211-4ivqlsgt 157 2 approach approach NN cord-345211-4ivqlsgt 157 3 to to TO cord-345211-4ivqlsgt 157 4 help help VB cord-345211-4ivqlsgt 157 5 distinguish distinguish VB cord-345211-4ivqlsgt 157 6 infection infection NN cord-345211-4ivqlsgt 157 7 from from IN cord-345211-4ivqlsgt 157 8 contamination contamination NN cord-345211-4ivqlsgt 157 9 or or CC cord-345211-4ivqlsgt 157 10 colonization colonization NN cord-345211-4ivqlsgt 157 11 is be VBZ cord-345211-4ivqlsgt 157 12 to to TO cord-345211-4ivqlsgt 157 13 quantify quantify VB cord-345211-4ivqlsgt 157 14 microbial microbial JJ cord-345211-4ivqlsgt 157 15 load load NN cord-345211-4ivqlsgt 157 16 by by IN cord-345211-4ivqlsgt 157 17 molecular molecular JJ cord-345211-4ivqlsgt 157 18 methods method NNS cord-345211-4ivqlsgt 157 19 . . . cord-345211-4ivqlsgt 158 1 The the DT cord-345211-4ivqlsgt 158 2 situation situation NN cord-345211-4ivqlsgt 158 3 is be VBZ cord-345211-4ivqlsgt 158 4 analogous analogous JJ cord-345211-4ivqlsgt 158 5 to to IN cord-345211-4ivqlsgt 158 6 culturebased culturebased JJ cord-345211-4ivqlsgt 158 7 methods method NNS cord-345211-4ivqlsgt 158 8 , , , cord-345211-4ivqlsgt 158 9 whereby whereby WRB cord-345211-4ivqlsgt 158 10 organisms organism NNS cord-345211-4ivqlsgt 158 11 isolated isolate VBN cord-345211-4ivqlsgt 158 12 in in IN cord-345211-4ivqlsgt 158 13 greater great JJR cord-345211-4ivqlsgt 158 14 quantities quantity NNS cord-345211-4ivqlsgt 158 15 from from IN cord-345211-4ivqlsgt 158 16 certain certain JJ cord-345211-4ivqlsgt 158 17 cultures culture NNS cord-345211-4ivqlsgt 158 18 are be VBP cord-345211-4ivqlsgt 158 19 regarded regard VBN cord-345211-4ivqlsgt 158 20 as as IN cord-345211-4ivqlsgt 158 21 more more RBR cord-345211-4ivqlsgt 158 22 likely likely JJ cord-345211-4ivqlsgt 158 23 to to TO cord-345211-4ivqlsgt 158 24 be be VB cord-345211-4ivqlsgt 158 25 clinically clinically RB cord-345211-4ivqlsgt 158 26 significant significant JJ cord-345211-4ivqlsgt 158 27 . . . cord-345211-4ivqlsgt 159 1 This this DT cord-345211-4ivqlsgt 159 2 approach approach NN cord-345211-4ivqlsgt 159 3 depends depend VBZ cord-345211-4ivqlsgt 159 4 on on IN cord-345211-4ivqlsgt 159 5 the the DT cord-345211-4ivqlsgt 159 6 determination determination NN cord-345211-4ivqlsgt 159 7 of of IN cord-345211-4ivqlsgt 159 8 cut cut VB cord-345211-4ivqlsgt 159 9 - - HYPH cord-345211-4ivqlsgt 159 10 off off RP cord-345211-4ivqlsgt 159 11 microbial microbial JJ cord-345211-4ivqlsgt 159 12 load load NN cord-345211-4ivqlsgt 159 13 levels level NNS cord-345211-4ivqlsgt 159 14 that that WDT cord-345211-4ivqlsgt 159 15 will will MD cord-345211-4ivqlsgt 159 16 provide provide VB cord-345211-4ivqlsgt 159 17 sufficient sufficient JJ cord-345211-4ivqlsgt 159 18 diagnostic diagnostic JJ cord-345211-4ivqlsgt 159 19 accuracy accuracy NN cord-345211-4ivqlsgt 159 20 to to TO cord-345211-4ivqlsgt 159 21 distinguish distinguish VB cord-345211-4ivqlsgt 159 22 infection infection NN cord-345211-4ivqlsgt 159 23 from from IN cord-345211-4ivqlsgt 159 24 colonization/ colonization/ CD cord-345211-4ivqlsgt 159 25 contamination contamination NN cord-345211-4ivqlsgt 159 26 . . . cord-345211-4ivqlsgt 160 1 However however RB cord-345211-4ivqlsgt 160 2 , , , cord-345211-4ivqlsgt 160 3 given give VBN cord-345211-4ivqlsgt 160 4 the the DT cord-345211-4ivqlsgt 160 5 lack lack NN cord-345211-4ivqlsgt 160 6 of of IN cord-345211-4ivqlsgt 160 7 suitable suitable JJ cord-345211-4ivqlsgt 160 8 comparator comparator NN cord-345211-4ivqlsgt 160 9 ' ' `` cord-345211-4ivqlsgt 160 10 gold gold NN cord-345211-4ivqlsgt 160 11 ' ' '' cord-345211-4ivqlsgt 160 12 standards standard NNS cord-345211-4ivqlsgt 160 13 , , , cord-345211-4ivqlsgt 160 14 these these DT cord-345211-4ivqlsgt 160 15 cut cut VB cord-345211-4ivqlsgt 160 16 - - HYPH cord-345211-4ivqlsgt 160 17 off off RP cord-345211-4ivqlsgt 160 18 values value NNS cord-345211-4ivqlsgt 160 19 are be VBP cord-345211-4ivqlsgt 160 20 very very RB cord-345211-4ivqlsgt 160 21 difficult difficult JJ cord-345211-4ivqlsgt 160 22 to to TO cord-345211-4ivqlsgt 160 23 identify identify VB cord-345211-4ivqlsgt 160 24 in in IN cord-345211-4ivqlsgt 160 25 a a DT cord-345211-4ivqlsgt 160 26 scientific scientific JJ cord-345211-4ivqlsgt 160 27 manner manner NN cord-345211-4ivqlsgt 160 28 . . . cord-345211-4ivqlsgt 161 1 They -PRON- PRP cord-345211-4ivqlsgt 161 2 may may MD cord-345211-4ivqlsgt 161 3 also also RB cord-345211-4ivqlsgt 161 4 vary vary VB cord-345211-4ivqlsgt 161 5 for for IN cord-345211-4ivqlsgt 161 6 different different JJ cord-345211-4ivqlsgt 161 7 microorganisms microorganism NNS cord-345211-4ivqlsgt 161 8 . . . cord-345211-4ivqlsgt 162 1 Quantitative quantitative JJ cord-345211-4ivqlsgt 162 2 multiplex multiplex NN cord-345211-4ivqlsgt 162 3 PCR PCR NNP cord-345211-4ivqlsgt 162 4 has have VBZ cord-345211-4ivqlsgt 162 5 been be VBN cord-345211-4ivqlsgt 162 6 used use VBN cord-345211-4ivqlsgt 162 7 to to TO cord-345211-4ivqlsgt 162 8 determine determine VB cord-345211-4ivqlsgt 162 9 the the DT cord-345211-4ivqlsgt 162 10 etiology etiology NN cord-345211-4ivqlsgt 162 11 of of IN cord-345211-4ivqlsgt 162 12 community community NN cord-345211-4ivqlsgt 162 13 - - HYPH cord-345211-4ivqlsgt 162 14 acquired acquire VBN cord-345211-4ivqlsgt 162 15 pneumonia pneumonia NN cord-345211-4ivqlsgt 162 16 in in IN cord-345211-4ivqlsgt 162 17 adults adult NNS cord-345211-4ivqlsgt 162 18 using use VBG cord-345211-4ivqlsgt 162 19 cutoffs cutoff NNS cord-345211-4ivqlsgt 162 20 developed develop VBN cord-345211-4ivqlsgt 162 21 for for IN cord-345211-4ivqlsgt 162 22 interpretation interpretation NN cord-345211-4ivqlsgt 162 23 of of IN cord-345211-4ivqlsgt 162 24 culture culture NN cord-345211-4ivqlsgt 162 25 results result NNS cord-345211-4ivqlsgt 162 26 from from IN cord-345211-4ivqlsgt 162 27 lower low JJR cord-345211-4ivqlsgt 162 28 respiratory respiratory JJ cord-345211-4ivqlsgt 162 29 tract tract NN cord-345211-4ivqlsgt 162 30 specimens specimen NNS cord-345211-4ivqlsgt 162 31 [ [ -LRB- cord-345211-4ivqlsgt 162 32 85 85 CD cord-345211-4ivqlsgt 162 33 , , , cord-345211-4ivqlsgt 162 34 86 86 CD cord-345211-4ivqlsgt 162 35 ] ] -RRB- cord-345211-4ivqlsgt 162 36 . . . cord-345211-4ivqlsgt 163 1 Not not RB cord-345211-4ivqlsgt 163 2 surprisingly surprisingly RB cord-345211-4ivqlsgt 163 3 , , , cord-345211-4ivqlsgt 163 4 the the DT cord-345211-4ivqlsgt 163 5 addition addition NN cord-345211-4ivqlsgt 163 6 of of IN cord-345211-4ivqlsgt 163 7 PCR PCR NNP cord-345211-4ivqlsgt 163 8 targets target NNS cord-345211-4ivqlsgt 163 9 for for IN cord-345211-4ivqlsgt 163 10 common common JJ cord-345211-4ivqlsgt 163 11 bacterial bacterial JJ cord-345211-4ivqlsgt 163 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 163 13 pathogens pathogen NNS cord-345211-4ivqlsgt 163 14 , , , cord-345211-4ivqlsgt 163 15 such such JJ cord-345211-4ivqlsgt 163 16 as as IN cord-345211-4ivqlsgt 163 17 S. S. NNP cord-345211-4ivqlsgt 163 18 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 163 19 , , , cord-345211-4ivqlsgt 163 20 resulted result VBD cord-345211-4ivqlsgt 163 21 in in IN cord-345211-4ivqlsgt 163 22 an an DT cord-345211-4ivqlsgt 163 23 etiological etiological JJ cord-345211-4ivqlsgt 163 24 diagnosis diagnosis NN cord-345211-4ivqlsgt 163 25 being be VBG cord-345211-4ivqlsgt 163 26 made make VBN cord-345211-4ivqlsgt 163 27 in in IN cord-345211-4ivqlsgt 163 28 a a DT cord-345211-4ivqlsgt 163 29 high high JJ cord-345211-4ivqlsgt 163 30 proportion proportion NN cord-345211-4ivqlsgt 163 31 of of IN cord-345211-4ivqlsgt 163 32 cases case NNS cord-345211-4ivqlsgt 163 33 . . . cord-345211-4ivqlsgt 164 1 However however RB cord-345211-4ivqlsgt 164 2 , , , cord-345211-4ivqlsgt 164 3 these these DT cord-345211-4ivqlsgt 164 4 cutoffs cutoff NNS cord-345211-4ivqlsgt 164 5 have have VBP cord-345211-4ivqlsgt 164 6 been be VBN cord-345211-4ivqlsgt 164 7 determined determine VBN cord-345211-4ivqlsgt 164 8 by by IN cord-345211-4ivqlsgt 164 9 expert expert JJ cord-345211-4ivqlsgt 164 10 opinion opinion NN cord-345211-4ivqlsgt 164 11 and and CC cord-345211-4ivqlsgt 164 12 , , , cord-345211-4ivqlsgt 164 13 although although IN cord-345211-4ivqlsgt 164 14 generally generally RB cord-345211-4ivqlsgt 164 15 intuitive intuitive JJ cord-345211-4ivqlsgt 164 16 , , , cord-345211-4ivqlsgt 164 17 might may MD cord-345211-4ivqlsgt 164 18 be be VB cord-345211-4ivqlsgt 164 19 quite quite RB cord-345211-4ivqlsgt 164 20 misleading misleading JJ cord-345211-4ivqlsgt 164 21 . . . cord-345211-4ivqlsgt 165 1 Despite despite IN cord-345211-4ivqlsgt 165 2 the the DT cord-345211-4ivqlsgt 165 3 challenges challenge NNS cord-345211-4ivqlsgt 165 4 in in IN cord-345211-4ivqlsgt 165 5 doing do VBG cord-345211-4ivqlsgt 165 6 so so RB cord-345211-4ivqlsgt 165 7 , , , cord-345211-4ivqlsgt 165 8 we -PRON- PRP cord-345211-4ivqlsgt 165 9 need need VBP cord-345211-4ivqlsgt 165 10 more more RBR cord-345211-4ivqlsgt 165 11 objective objective JJ cord-345211-4ivqlsgt 165 12 assessment assessment NN cord-345211-4ivqlsgt 165 13 of of IN cord-345211-4ivqlsgt 165 14 cut cut VB cord-345211-4ivqlsgt 165 15 - - HYPH cord-345211-4ivqlsgt 165 16 off off RP cord-345211-4ivqlsgt 165 17 values value NNS cord-345211-4ivqlsgt 165 18 using use VBG cord-345211-4ivqlsgt 165 19 good good JJ cord-345211-4ivqlsgt 165 20 scientific scientific JJ cord-345211-4ivqlsgt 165 21 and and CC cord-345211-4ivqlsgt 165 22 epidemiologic epidemiologic JJ cord-345211-4ivqlsgt 165 23 principles principle NNS cord-345211-4ivqlsgt 165 24 . . . cord-345211-4ivqlsgt 166 1 Quantitative quantitative JJ cord-345211-4ivqlsgt 166 2 approaches approach NNS cord-345211-4ivqlsgt 166 3 have have VBP cord-345211-4ivqlsgt 166 4 also also RB cord-345211-4ivqlsgt 166 5 been be VBN cord-345211-4ivqlsgt 166 6 applied apply VBN cord-345211-4ivqlsgt 166 7 to to IN cord-345211-4ivqlsgt 166 8 nasopharyngeal nasopharyngeal JJ cord-345211-4ivqlsgt 166 9 specimens specimen NNS cord-345211-4ivqlsgt 166 10 . . . cord-345211-4ivqlsgt 167 1 Among among IN cord-345211-4ivqlsgt 167 2 HIV HIV NNP cord-345211-4ivqlsgt 167 3 - - HYPH cord-345211-4ivqlsgt 167 4 infected infect VBN cord-345211-4ivqlsgt 167 5 adults adult NNS cord-345211-4ivqlsgt 167 6 in in IN cord-345211-4ivqlsgt 167 7 South South NNP cord-345211-4ivqlsgt 167 8 Africa Africa NNP cord-345211-4ivqlsgt 167 9 , , , cord-345211-4ivqlsgt 167 10 quantitative quantitative JJ cord-345211-4ivqlsgt 167 11 PCR PCR NNP cord-345211-4ivqlsgt 167 12 testing testing NN cord-345211-4ivqlsgt 167 13 of of IN cord-345211-4ivqlsgt 167 14 nasopharyngeal nasopharyngeal JJ cord-345211-4ivqlsgt 167 15 samples sample NNS cord-345211-4ivqlsgt 167 16 distinguished distinguish VBN cord-345211-4ivqlsgt 167 17 between between IN cord-345211-4ivqlsgt 167 18 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 167 19 pneumonia pneumonia NN cord-345211-4ivqlsgt 167 20 and and CC cord-345211-4ivqlsgt 167 21 asymptomatic asymptomatic JJ cord-345211-4ivqlsgt 167 22 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 167 23 colonization colonization NN cord-345211-4ivqlsgt 167 24 with with IN cord-345211-4ivqlsgt 167 25 reasonable reasonable JJ cord-345211-4ivqlsgt 167 26 diagnostic diagnostic JJ cord-345211-4ivqlsgt 167 27 accuracy accuracy NN cord-345211-4ivqlsgt 167 28 [ [ -LRB- cord-345211-4ivqlsgt 167 29 87 87 CD cord-345211-4ivqlsgt 167 30 , , , cord-345211-4ivqlsgt 167 31 88 88 CD cord-345211-4ivqlsgt 167 32 ] ] -RRB- cord-345211-4ivqlsgt 167 33 . . . cord-345211-4ivqlsgt 168 1 Data datum NNS cord-345211-4ivqlsgt 168 2 from from IN cord-345211-4ivqlsgt 168 3 other other JJ cord-345211-4ivqlsgt 168 4 populations population NNS cord-345211-4ivqlsgt 168 5 are be VBP cord-345211-4ivqlsgt 168 6 needed need VBN cord-345211-4ivqlsgt 168 7 in in IN cord-345211-4ivqlsgt 168 8 order order NN cord-345211-4ivqlsgt 168 9 to to TO cord-345211-4ivqlsgt 168 10 assess assess VB cord-345211-4ivqlsgt 168 11 whether whether IN cord-345211-4ivqlsgt 168 12 this this DT cord-345211-4ivqlsgt 168 13 method method NN cord-345211-4ivqlsgt 168 14 can can MD cord-345211-4ivqlsgt 168 15 be be VB cord-345211-4ivqlsgt 168 16 used use VBN cord-345211-4ivqlsgt 168 17 in in IN cord-345211-4ivqlsgt 168 18 clinical clinical JJ cord-345211-4ivqlsgt 168 19 practice practice NN cord-345211-4ivqlsgt 168 20 . . . cord-345211-4ivqlsgt 169 1 Microbial microbial JJ cord-345211-4ivqlsgt 169 2 load load NN cord-345211-4ivqlsgt 169 3 in in IN cord-345211-4ivqlsgt 169 4 pneumonia pneumonia NN cord-345211-4ivqlsgt 169 5 can can MD cord-345211-4ivqlsgt 169 6 also also RB cord-345211-4ivqlsgt 169 7 be be VB cord-345211-4ivqlsgt 169 8 a a DT cord-345211-4ivqlsgt 169 9 prognostic prognostic JJ cord-345211-4ivqlsgt 169 10 marker marker NN cord-345211-4ivqlsgt 169 11 . . . cord-345211-4ivqlsgt 170 1 For for IN cord-345211-4ivqlsgt 170 2 example example NN cord-345211-4ivqlsgt 170 3 , , , cord-345211-4ivqlsgt 170 4 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 170 5 density density NN cord-345211-4ivqlsgt 170 6 in in IN cord-345211-4ivqlsgt 170 7 the the DT cord-345211-4ivqlsgt 170 8 nasopharynx nasopharynx NN cord-345211-4ivqlsgt 170 9 [ [ -LRB- cord-345211-4ivqlsgt 170 10 89 89 CD cord-345211-4ivqlsgt 170 11 ] ] -RRB- cord-345211-4ivqlsgt 170 12 and and CC cord-345211-4ivqlsgt 170 13 blood blood NN cord-345211-4ivqlsgt 170 14 [ [ -LRB- cord-345211-4ivqlsgt 170 15 90 90 CD cord-345211-4ivqlsgt 170 16 , , , cord-345211-4ivqlsgt 170 17 91 91 CD cord-345211-4ivqlsgt 170 18 ] ] -RRB- cord-345211-4ivqlsgt 170 19 are be VBP cord-345211-4ivqlsgt 170 20 associated associate VBN cord-345211-4ivqlsgt 170 21 with with IN cord-345211-4ivqlsgt 170 22 disease disease NN cord-345211-4ivqlsgt 170 23 severity severity NN cord-345211-4ivqlsgt 170 24 in in IN cord-345211-4ivqlsgt 170 25 adults adult NNS cord-345211-4ivqlsgt 170 26 . . . cord-345211-4ivqlsgt 171 1 We -PRON- PRP cord-345211-4ivqlsgt 171 2 can can MD cord-345211-4ivqlsgt 171 3 probably probably RB cord-345211-4ivqlsgt 171 4 also also RB cord-345211-4ivqlsgt 171 5 be be VB cord-345211-4ivqlsgt 171 6 more more RBR cord-345211-4ivqlsgt 171 7 innovative innovative JJ cord-345211-4ivqlsgt 171 8 with with IN cord-345211-4ivqlsgt 171 9 statistical statistical JJ cord-345211-4ivqlsgt 171 10 methods method NNS cord-345211-4ivqlsgt 171 11 to to TO cord-345211-4ivqlsgt 171 12 help help VB cord-345211-4ivqlsgt 171 13 interpret interpret VB cord-345211-4ivqlsgt 171 14 molecular molecular JJ cord-345211-4ivqlsgt 171 15 test test NN cord-345211-4ivqlsgt 171 16 results result NNS cord-345211-4ivqlsgt 171 17 . . . cord-345211-4ivqlsgt 172 1 Statistical statistical JJ cord-345211-4ivqlsgt 172 2 modeling modeling NN cord-345211-4ivqlsgt 172 3 techniques technique NNS cord-345211-4ivqlsgt 172 4 can can MD cord-345211-4ivqlsgt 172 5 be be VB cord-345211-4ivqlsgt 172 6 used use VBN cord-345211-4ivqlsgt 172 7 to to TO cord-345211-4ivqlsgt 172 8 help help VB cord-345211-4ivqlsgt 172 9 overcome overcome VB cord-345211-4ivqlsgt 172 10 the the DT cord-345211-4ivqlsgt 172 11 limitations limitation NNS cord-345211-4ivqlsgt 172 12 of of IN cord-345211-4ivqlsgt 172 13 diagnostic diagnostic JJ cord-345211-4ivqlsgt 172 14 testing testing NN cord-345211-4ivqlsgt 172 15 for for IN cord-345211-4ivqlsgt 172 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 172 17 , , , cord-345211-4ivqlsgt 172 18 particularly particularly RB cord-345211-4ivqlsgt 172 19 the the DT cord-345211-4ivqlsgt 172 20 lack lack NN cord-345211-4ivqlsgt 172 21 of of IN cord-345211-4ivqlsgt 172 22 good good JJ cord-345211-4ivqlsgt 172 23 comparator comparator NN cord-345211-4ivqlsgt 172 24 standards standard NNS cord-345211-4ivqlsgt 172 25 . . . cord-345211-4ivqlsgt 173 1 Latent Latent NNP cord-345211-4ivqlsgt 173 2 class class NN cord-345211-4ivqlsgt 173 3 analysis analysis NN cord-345211-4ivqlsgt 173 4 has have VBZ cord-345211-4ivqlsgt 173 5 been be VBN cord-345211-4ivqlsgt 173 6 used use VBN cord-345211-4ivqlsgt 173 7 to to TO cord-345211-4ivqlsgt 173 8 determine determine VB cord-345211-4ivqlsgt 173 9 the the DT cord-345211-4ivqlsgt 173 10 prevalence prevalence NN cord-345211-4ivqlsgt 173 11 of of IN cord-345211-4ivqlsgt 173 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 173 13 caused cause VBN cord-345211-4ivqlsgt 173 14 by by IN cord-345211-4ivqlsgt 173 15 specific specific JJ cord-345211-4ivqlsgt 173 16 pathogens pathogen NNS cord-345211-4ivqlsgt 173 17 in in IN cord-345211-4ivqlsgt 173 18 epidemiologic epidemiologic JJ cord-345211-4ivqlsgt 173 19 studies study NNS cord-345211-4ivqlsgt 173 20 [ [ -LRB- cord-345211-4ivqlsgt 173 21 92 92 CD cord-345211-4ivqlsgt 173 22 , , , cord-345211-4ivqlsgt 173 23 93 93 CD cord-345211-4ivqlsgt 173 24 ] ] -RRB- cord-345211-4ivqlsgt 173 25 and and CC cord-345211-4ivqlsgt 173 26 for for IN cord-345211-4ivqlsgt 173 27 the the DT cord-345211-4ivqlsgt 173 28 assessment assessment NN cord-345211-4ivqlsgt 173 29 of of IN cord-345211-4ivqlsgt 173 30 diagnostic diagnostic JJ cord-345211-4ivqlsgt 173 31 tests test NNS cord-345211-4ivqlsgt 173 32 in in IN cord-345211-4ivqlsgt 173 33 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 173 34 [ [ -LRB- cord-345211-4ivqlsgt 173 35 94 94 CD cord-345211-4ivqlsgt 173 36 , , , cord-345211-4ivqlsgt 173 37 95 95 CD cord-345211-4ivqlsgt 173 38 ] ] -RRB- cord-345211-4ivqlsgt 173 39 . . . cord-345211-4ivqlsgt 174 1 Possibly possibly RB cord-345211-4ivqlsgt 174 2 the the DT cord-345211-4ivqlsgt 174 3 most most RBS cord-345211-4ivqlsgt 174 4 sophisticated sophisticated JJ cord-345211-4ivqlsgt 174 5 use use NN cord-345211-4ivqlsgt 174 6 of of IN cord-345211-4ivqlsgt 174 7 statistical statistical JJ cord-345211-4ivqlsgt 174 8 modeling modeling NN cord-345211-4ivqlsgt 174 9 techniques technique NNS cord-345211-4ivqlsgt 174 10 in in IN cord-345211-4ivqlsgt 174 11 the the DT cord-345211-4ivqlsgt 174 12 context context NN cord-345211-4ivqlsgt 174 13 of of IN cord-345211-4ivqlsgt 174 14 pneumonia pneumonia NN cord-345211-4ivqlsgt 174 15 etiology etiology NN cord-345211-4ivqlsgt 174 16 is be VBZ cord-345211-4ivqlsgt 174 17 currently currently RB cord-345211-4ivqlsgt 174 18 being be VBG cord-345211-4ivqlsgt 174 19 undertaken undertake VBN cord-345211-4ivqlsgt 174 20 as as IN cord-345211-4ivqlsgt 174 21 part part NN cord-345211-4ivqlsgt 174 22 of of IN cord-345211-4ivqlsgt 174 23 the the DT cord-345211-4ivqlsgt 174 24 Pneumonia Pneumonia NNP cord-345211-4ivqlsgt 174 25 Etiology Etiology NNP cord-345211-4ivqlsgt 174 26 Research Research NNP cord-345211-4ivqlsgt 174 27 for for IN cord-345211-4ivqlsgt 174 28 Child Child NNP cord-345211-4ivqlsgt 174 29 Health Health NNP cord-345211-4ivqlsgt 174 30 ( ( -LRB- cord-345211-4ivqlsgt 174 31 PERCH PERCH NNP cord-345211-4ivqlsgt 174 32 ) ) -RRB- cord-345211-4ivqlsgt 174 33 study study NN cord-345211-4ivqlsgt 174 34 [ [ -LRB- cord-345211-4ivqlsgt 174 35 96 96 CD cord-345211-4ivqlsgt 174 36 ] ] -RRB- cord-345211-4ivqlsgt 174 37 . . . cord-345211-4ivqlsgt 175 1 PERCH perch NN cord-345211-4ivqlsgt 175 2 is be VBZ cord-345211-4ivqlsgt 175 3 a a DT cord-345211-4ivqlsgt 175 4 large large JJ cord-345211-4ivqlsgt 175 5 7-country 7-country CD cord-345211-4ivqlsgt 175 6 case case NN cord-345211-4ivqlsgt 175 7 - - HYPH cord-345211-4ivqlsgt 175 8 control control NN cord-345211-4ivqlsgt 175 9 study study NN cord-345211-4ivqlsgt 175 10 focused focus VBD cord-345211-4ivqlsgt 175 11 on on IN cord-345211-4ivqlsgt 175 12 the the DT cord-345211-4ivqlsgt 175 13 causes cause NNS cord-345211-4ivqlsgt 175 14 of of IN cord-345211-4ivqlsgt 175 15 severe severe JJ cord-345211-4ivqlsgt 175 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 175 17 in in IN cord-345211-4ivqlsgt 175 18 young young JJ cord-345211-4ivqlsgt 175 19 children child NNS cord-345211-4ivqlsgt 175 20 from from IN cord-345211-4ivqlsgt 175 21 developing develop VBG cord-345211-4ivqlsgt 175 22 countries country NNS cord-345211-4ivqlsgt 175 23 , , , cord-345211-4ivqlsgt 175 24 the the DT cord-345211-4ivqlsgt 175 25 findings finding NNS cord-345211-4ivqlsgt 175 26 of of IN cord-345211-4ivqlsgt 175 27 which which WDT cord-345211-4ivqlsgt 175 28 will will MD cord-345211-4ivqlsgt 175 29 be be VB cord-345211-4ivqlsgt 175 30 published publish VBN cord-345211-4ivqlsgt 175 31 in in IN cord-345211-4ivqlsgt 175 32 2016 2016 CD cord-345211-4ivqlsgt 175 33 . . . cord-345211-4ivqlsgt 176 1 In in IN cord-345211-4ivqlsgt 176 2 this this DT cord-345211-4ivqlsgt 176 3 study study NN cord-345211-4ivqlsgt 176 4 , , , cord-345211-4ivqlsgt 176 5 partially partially RB cord-345211-4ivqlsgt 176 6 latent latent JJ cord-345211-4ivqlsgt 176 7 class class NN cord-345211-4ivqlsgt 176 8 models model NNS cord-345211-4ivqlsgt 176 9 have have VBP cord-345211-4ivqlsgt 176 10 been be VBN cord-345211-4ivqlsgt 176 11 designed design VBN cord-345211-4ivqlsgt 176 12 for for IN cord-345211-4ivqlsgt 176 13 estimating estimate VBG cord-345211-4ivqlsgt 176 14 the the DT cord-345211-4ivqlsgt 176 15 population population NN cord-345211-4ivqlsgt 176 16 etiology etiology NN cord-345211-4ivqlsgt 176 17 distribution distribution NN cord-345211-4ivqlsgt 176 18 and and CC cord-345211-4ivqlsgt 176 19 the the DT cord-345211-4ivqlsgt 176 20 individual individual JJ cord-345211-4ivqlsgt 176 21 etiology etiology NN cord-345211-4ivqlsgt 176 22 probabilities probability NNS cord-345211-4ivqlsgt 176 23 for for IN cord-345211-4ivqlsgt 176 24 specific specific JJ cord-345211-4ivqlsgt 176 25 pneumonia pneumonia NN cord-345211-4ivqlsgt 176 26 pathogens pathogen NNS cord-345211-4ivqlsgt 176 27 , , , cord-345211-4ivqlsgt 176 28 with with IN cord-345211-4ivqlsgt 176 29 a a DT cord-345211-4ivqlsgt 176 30 major major JJ cord-345211-4ivqlsgt 176 31 focus focus NN cord-345211-4ivqlsgt 176 32 on on IN cord-345211-4ivqlsgt 176 33 molecular molecular JJ cord-345211-4ivqlsgt 176 34 diagnostic diagnostic JJ cord-345211-4ivqlsgt 176 35 test test NN cord-345211-4ivqlsgt 176 36 results result NNS cord-345211-4ivqlsgt 176 37 [ [ -LRB- cord-345211-4ivqlsgt 176 38 97 97 CD cord-345211-4ivqlsgt 176 39 ] ] -RRB- cord-345211-4ivqlsgt 176 40 . . . cord-345211-4ivqlsgt 177 1 The the DT cord-345211-4ivqlsgt 177 2 findings finding NNS cord-345211-4ivqlsgt 177 3 of of IN cord-345211-4ivqlsgt 177 4 PERCH perch NN cord-345211-4ivqlsgt 177 5 are be VBP cord-345211-4ivqlsgt 177 6 awaited await VBN cord-345211-4ivqlsgt 177 7 with with IN cord-345211-4ivqlsgt 177 8 great great JJ cord-345211-4ivqlsgt 177 9 anticipation anticipation NN cord-345211-4ivqlsgt 177 10 , , , cord-345211-4ivqlsgt 177 11 as as IN cord-345211-4ivqlsgt 177 12 this this DT cord-345211-4ivqlsgt 177 13 approach approach NN cord-345211-4ivqlsgt 177 14 has have VBZ cord-345211-4ivqlsgt 177 15 never never RB cord-345211-4ivqlsgt 177 16 before before RB cord-345211-4ivqlsgt 177 17 been be VBN cord-345211-4ivqlsgt 177 18 so so RB cord-345211-4ivqlsgt 177 19 extensively extensively RB cord-345211-4ivqlsgt 177 20 applied apply VBN cord-345211-4ivqlsgt 177 21 to to IN cord-345211-4ivqlsgt 177 22 the the DT cord-345211-4ivqlsgt 177 23 etiology etiology NN cord-345211-4ivqlsgt 177 24 of of IN cord-345211-4ivqlsgt 177 25 an an DT cord-345211-4ivqlsgt 177 26 infectious infectious JJ cord-345211-4ivqlsgt 177 27 disease disease NN cord-345211-4ivqlsgt 177 28 . . . cord-345211-4ivqlsgt 178 1 We -PRON- PRP cord-345211-4ivqlsgt 178 2 have have VBP cord-345211-4ivqlsgt 178 3 entered enter VBN cord-345211-4ivqlsgt 178 4 a a DT cord-345211-4ivqlsgt 178 5 new new JJ cord-345211-4ivqlsgt 178 6 age age NN cord-345211-4ivqlsgt 178 7 in in IN cord-345211-4ivqlsgt 178 8 pneumonia pneumonia NN cord-345211-4ivqlsgt 178 9 diagnostics diagnostic NNS cord-345211-4ivqlsgt 178 10 that that WDT cord-345211-4ivqlsgt 178 11 needs need VBZ cord-345211-4ivqlsgt 178 12 to to TO cord-345211-4ivqlsgt 178 13 look look VB cord-345211-4ivqlsgt 178 14 beyond beyond IN cord-345211-4ivqlsgt 178 15 the the DT cord-345211-4ivqlsgt 178 16 targeting targeting NN cord-345211-4ivqlsgt 178 17 of of IN cord-345211-4ivqlsgt 178 18 a a DT cord-345211-4ivqlsgt 178 19 limited limited JJ cord-345211-4ivqlsgt 178 20 number number NN cord-345211-4ivqlsgt 178 21 of of IN cord-345211-4ivqlsgt 178 22 potential potential JJ cord-345211-4ivqlsgt 178 23 pathogens pathogen NNS cord-345211-4ivqlsgt 178 24 . . . cord-345211-4ivqlsgt 179 1 New new JJ cord-345211-4ivqlsgt 179 2 knowledge knowledge NN cord-345211-4ivqlsgt 179 3 about about IN cord-345211-4ivqlsgt 179 4 the the DT cord-345211-4ivqlsgt 179 5 lung lung NN cord-345211-4ivqlsgt 179 6 microbiome microbiome NN cord-345211-4ivqlsgt 179 7 and and CC cord-345211-4ivqlsgt 179 8 pneumonia pneumonia NN cord-345211-4ivqlsgt 179 9 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 179 10 , , , cord-345211-4ivqlsgt 179 11 together together RB cord-345211-4ivqlsgt 179 12 with with IN cord-345211-4ivqlsgt 179 13 emerging emerge VBG cord-345211-4ivqlsgt 179 14 developments development NNS cord-345211-4ivqlsgt 179 15 in in IN cord-345211-4ivqlsgt 179 16 sequencing sequencing NN cord-345211-4ivqlsgt 179 17 technology technology NN cord-345211-4ivqlsgt 179 18 , , , cord-345211-4ivqlsgt 179 19 provide provide VB cord-345211-4ivqlsgt 179 20 opportunities opportunity NNS cord-345211-4ivqlsgt 179 21 for for IN cord-345211-4ivqlsgt 179 22 novel novel JJ cord-345211-4ivqlsgt 179 23 diagnostic diagnostic JJ cord-345211-4ivqlsgt 179 24 tools tool NNS cord-345211-4ivqlsgt 179 25 to to TO cord-345211-4ivqlsgt 179 26 help help VB cord-345211-4ivqlsgt 179 27 better well RBR cord-345211-4ivqlsgt 179 28 guide guide VB cord-345211-4ivqlsgt 179 29 the the DT cord-345211-4ivqlsgt 179 30 management management NN cord-345211-4ivqlsgt 179 31 of of IN cord-345211-4ivqlsgt 179 32 pneumonia pneumonia NN cord-345211-4ivqlsgt 179 33 . . . cord-345211-4ivqlsgt 180 1 Molecular molecular JJ cord-345211-4ivqlsgt 180 2 tests test NNS cord-345211-4ivqlsgt 180 3 are be VBP cord-345211-4ivqlsgt 180 4 now now RB cord-345211-4ivqlsgt 180 5 mainstream mainstream JJ cord-345211-4ivqlsgt 180 6 diagnostics diagnostic NNS cord-345211-4ivqlsgt 180 7 for for IN cord-345211-4ivqlsgt 180 8 many many JJ cord-345211-4ivqlsgt 180 9 respiratory respiratory JJ cord-345211-4ivqlsgt 180 10 infections infection NNS cord-345211-4ivqlsgt 180 11 , , , cord-345211-4ivqlsgt 180 12 although although IN cord-345211-4ivqlsgt 180 13 we -PRON- PRP cord-345211-4ivqlsgt 180 14 still still RB cord-345211-4ivqlsgt 180 15 have have VBP cord-345211-4ivqlsgt 180 16 much much JJ cord-345211-4ivqlsgt 180 17 to to TO cord-345211-4ivqlsgt 180 18 learn learn VB cord-345211-4ivqlsgt 180 19 about about IN cord-345211-4ivqlsgt 180 20 using use VBG cord-345211-4ivqlsgt 180 21 them -PRON- PRP cord-345211-4ivqlsgt 180 22 more more RBR cord-345211-4ivqlsgt 180 23 effectively effectively RB cord-345211-4ivqlsgt 180 24 to to TO cord-345211-4ivqlsgt 180 25 assist assist VB cord-345211-4ivqlsgt 180 26 with with IN cord-345211-4ivqlsgt 180 27 the the DT cord-345211-4ivqlsgt 180 28 management management NN cord-345211-4ivqlsgt 180 29 of of IN cord-345211-4ivqlsgt 180 30 pneumonia pneumonia NN cord-345211-4ivqlsgt 180 31 . . . cord-345211-4ivqlsgt 181 1 Those those DT cord-345211-4ivqlsgt 181 2 involved involve VBN cord-345211-4ivqlsgt 181 3 in in IN cord-345211-4ivqlsgt 181 4 molecular molecular JJ cord-345211-4ivqlsgt 181 5 diagnostic diagnostic JJ cord-345211-4ivqlsgt 181 6 test test NN cord-345211-4ivqlsgt 181 7 development development NN cord-345211-4ivqlsgt 181 8 for for IN cord-345211-4ivqlsgt 181 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 181 10 need need VBP cord-345211-4ivqlsgt 181 11 to to TO cord-345211-4ivqlsgt 181 12 look look VB cord-345211-4ivqlsgt 181 13 beyond beyond IN cord-345211-4ivqlsgt 181 14 the the DT cord-345211-4ivqlsgt 181 15 simple simple JJ cord-345211-4ivqlsgt 181 16 detection detection NN cord-345211-4ivqlsgt 181 17 of of IN cord-345211-4ivqlsgt 181 18 specific specific JJ cord-345211-4ivqlsgt 181 19 known know VBN cord-345211-4ivqlsgt 181 20 pathogens pathogen NNS cord-345211-4ivqlsgt 181 21 and and CC cord-345211-4ivqlsgt 181 22 also also RB cord-345211-4ivqlsgt 181 23 provide provide VB cord-345211-4ivqlsgt 181 24 means mean NNS cord-345211-4ivqlsgt 181 25 to to TO cord-345211-4ivqlsgt 181 26 accurately accurately RB cord-345211-4ivqlsgt 181 27 interpret interpret VB cord-345211-4ivqlsgt 181 28 the the DT cord-345211-4ivqlsgt 181 29 clinical clinical JJ cord-345211-4ivqlsgt 181 30 significance significance NN cord-345211-4ivqlsgt 181 31 of of IN cord-345211-4ivqlsgt 181 32 a a DT cord-345211-4ivqlsgt 181 33 positive positive JJ cord-345211-4ivqlsgt 181 34 result result NN cord-345211-4ivqlsgt 181 35 . . . cord-345211-4ivqlsgt 182 1 It -PRON- PRP cord-345211-4ivqlsgt 182 2 is be VBZ cord-345211-4ivqlsgt 182 3 not not RB cord-345211-4ivqlsgt 182 4 good good JJ cord-345211-4ivqlsgt 182 5 enough enough RB cord-345211-4ivqlsgt 182 6 to to TO cord-345211-4ivqlsgt 182 7 simply simply RB cord-345211-4ivqlsgt 182 8 assess assess VB cord-345211-4ivqlsgt 182 9 a a DT cord-345211-4ivqlsgt 182 10 new new JJ cord-345211-4ivqlsgt 182 11 test test NN cord-345211-4ivqlsgt 182 12 by by IN cord-345211-4ivqlsgt 182 13 measuring measure VBG cord-345211-4ivqlsgt 182 14 analytical analytical JJ cord-345211-4ivqlsgt 182 15 sensitivity sensitivity NN cord-345211-4ivqlsgt 182 16 and and CC cord-345211-4ivqlsgt 182 17 making make VBG cord-345211-4ivqlsgt 182 18 comparisons comparison NNS cord-345211-4ivqlsgt 182 19 to to IN cord-345211-4ivqlsgt 182 20 the the DT cord-345211-4ivqlsgt 182 21 performance performance NN cord-345211-4ivqlsgt 182 22 of of IN cord-345211-4ivqlsgt 182 23 other other JJ cord-345211-4ivqlsgt 182 24 similar similar JJ cord-345211-4ivqlsgt 182 25 assays assay NNS cord-345211-4ivqlsgt 182 26 . . . cord-345211-4ivqlsgt 183 1 Diagnostic diagnostic JJ cord-345211-4ivqlsgt 183 2 tests test NNS cord-345211-4ivqlsgt 183 3 must must MD cord-345211-4ivqlsgt 183 4 be be VB cord-345211-4ivqlsgt 183 5 evaluated evaluate VBN cord-345211-4ivqlsgt 183 6 properly properly RB cord-345211-4ivqlsgt 183 7 following follow VBG cord-345211-4ivqlsgt 183 8 good good JJ cord-345211-4ivqlsgt 183 9 epidemiological epidemiological JJ cord-345211-4ivqlsgt 183 10 principles principle NNS cord-345211-4ivqlsgt 183 11 . . . cord-345211-4ivqlsgt 184 1 New new JJ cord-345211-4ivqlsgt 184 2 developments development NNS cord-345211-4ivqlsgt 184 3 in in IN cord-345211-4ivqlsgt 184 4 molecular molecular JJ cord-345211-4ivqlsgt 184 5 diagnostics diagnostic NNS cord-345211-4ivqlsgt 184 6 must must MD cord-345211-4ivqlsgt 184 7 also also RB cord-345211-4ivqlsgt 184 8 be be VB cord-345211-4ivqlsgt 184 9 cognizant cognizant JJ cord-345211-4ivqlsgt 184 10 of of IN cord-345211-4ivqlsgt 184 11 emerging emerge VBG cord-345211-4ivqlsgt 184 12 information information NN cord-345211-4ivqlsgt 184 13 about about IN cord-345211-4ivqlsgt 184 14 the the DT cord-345211-4ivqlsgt 184 15 lung lung NN cord-345211-4ivqlsgt 184 16 microbiome microbiome NN cord-345211-4ivqlsgt 184 17 , , , cord-345211-4ivqlsgt 184 18 which which WDT cord-345211-4ivqlsgt 184 19 will will MD cord-345211-4ivqlsgt 184 20 likely likely RB cord-345211-4ivqlsgt 184 21 provide provide VB cord-345211-4ivqlsgt 184 22 opportunities opportunity NNS cord-345211-4ivqlsgt 184 23 for for IN cord-345211-4ivqlsgt 184 24 the the DT cord-345211-4ivqlsgt 184 25 discovery discovery NN cord-345211-4ivqlsgt 184 26 of of IN cord-345211-4ivqlsgt 184 27 novel novel JJ cord-345211-4ivqlsgt 184 28 markers marker NNS cord-345211-4ivqlsgt 184 29 to to TO cord-345211-4ivqlsgt 184 30 help help VB cord-345211-4ivqlsgt 184 31 guide guide VB cord-345211-4ivqlsgt 184 32 pneumonia pneumonia NN cord-345211-4ivqlsgt 184 33 management management NN cord-345211-4ivqlsgt 184 34 . . . cord-345211-4ivqlsgt 185 1 The the DT cord-345211-4ivqlsgt 185 2 recent recent JJ cord-345211-4ivqlsgt 185 3 expansion expansion NN cord-345211-4ivqlsgt 185 4 in in IN cord-345211-4ivqlsgt 185 5 the the DT cord-345211-4ivqlsgt 185 6 number number NN cord-345211-4ivqlsgt 185 7 and and CC cord-345211-4ivqlsgt 185 8 variety variety NN cord-345211-4ivqlsgt 185 9 of of IN cord-345211-4ivqlsgt 185 10 commercial commercial JJ cord-345211-4ivqlsgt 185 11 NATs NATs NNP cord-345211-4ivqlsgt 185 12 is be VBZ cord-345211-4ivqlsgt 185 13 likely likely JJ cord-345211-4ivqlsgt 185 14 to to TO cord-345211-4ivqlsgt 185 15 continue continue VB cord-345211-4ivqlsgt 185 16 , , , cord-345211-4ivqlsgt 185 17 leading lead VBG cord-345211-4ivqlsgt 185 18 to to IN cord-345211-4ivqlsgt 185 19 greater great JJR cord-345211-4ivqlsgt 185 20 uptake uptake NN cord-345211-4ivqlsgt 185 21 by by IN cord-345211-4ivqlsgt 185 22 diagnostic diagnostic JJ cord-345211-4ivqlsgt 185 23 laboratories laboratory NNS cord-345211-4ivqlsgt 185 24 and and CC cord-345211-4ivqlsgt 185 25 greater great JJR cord-345211-4ivqlsgt 185 26 incorporation incorporation NN cord-345211-4ivqlsgt 185 27 into into IN cord-345211-4ivqlsgt 185 28 diagnostic diagnostic JJ cord-345211-4ivqlsgt 185 29 test test NN cord-345211-4ivqlsgt 185 30 algorithms algorithm NNS cord-345211-4ivqlsgt 185 31 and and CC cord-345211-4ivqlsgt 185 32 guidelines guideline NNS cord-345211-4ivqlsgt 185 33 for for IN cord-345211-4ivqlsgt 185 34 the the DT cord-345211-4ivqlsgt 185 35 management management NN cord-345211-4ivqlsgt 185 36 of of IN cord-345211-4ivqlsgt 185 37 pneumonia pneumonia NN cord-345211-4ivqlsgt 185 38 . . . cord-345211-4ivqlsgt 186 1 The the DT cord-345211-4ivqlsgt 186 2 provision provision NN cord-345211-4ivqlsgt 186 3 of of IN cord-345211-4ivqlsgt 186 4 even even RB cord-345211-4ivqlsgt 186 5 more more JJR cord-345211-4ivqlsgt 186 6 user user NN cord-345211-4ivqlsgt 186 7 - - HYPH cord-345211-4ivqlsgt 186 8 friendly friendly JJ cord-345211-4ivqlsgt 186 9 platforms platform NNS cord-345211-4ivqlsgt 186 10 will will MD cord-345211-4ivqlsgt 186 11 enable enable VB cord-345211-4ivqlsgt 186 12 deployment deployment NN cord-345211-4ivqlsgt 186 13 of of IN cord-345211-4ivqlsgt 186 14 these these DT cord-345211-4ivqlsgt 186 15 tests test NNS cord-345211-4ivqlsgt 186 16 in in IN cord-345211-4ivqlsgt 186 17 laboratories laboratory NNS cord-345211-4ivqlsgt 186 18 that that WDT cord-345211-4ivqlsgt 186 19 have have VBP cord-345211-4ivqlsgt 186 20 not not RB cord-345211-4ivqlsgt 186 21 traditionally traditionally RB cord-345211-4ivqlsgt 186 22 used use VBN cord-345211-4ivqlsgt 186 23 molecular molecular JJ cord-345211-4ivqlsgt 186 24 diagnostics diagnostic NNS cord-345211-4ivqlsgt 186 25 . . . cord-345211-4ivqlsgt 187 1 Further further JJ cord-345211-4ivqlsgt 187 2 efforts effort NNS cord-345211-4ivqlsgt 187 3 are be VBP cord-345211-4ivqlsgt 187 4 needed need VBN cord-345211-4ivqlsgt 187 5 to to TO cord-345211-4ivqlsgt 187 6 evaluate evaluate VB cord-345211-4ivqlsgt 187 7 the the DT cord-345211-4ivqlsgt 187 8 clinical clinical JJ cord-345211-4ivqlsgt 187 9 application application NN cord-345211-4ivqlsgt 187 10 of of IN cord-345211-4ivqlsgt 187 11 microbial microbial JJ cord-345211-4ivqlsgt 187 12 load load NN cord-345211-4ivqlsgt 187 13 measurement measurement NN cord-345211-4ivqlsgt 187 14 for for IN cord-345211-4ivqlsgt 187 15 the the DT cord-345211-4ivqlsgt 187 16 purpose purpose NN cord-345211-4ivqlsgt 187 17 of of IN cord-345211-4ivqlsgt 187 18 distinguishing distinguish VBG cord-345211-4ivqlsgt 187 19 pathogens pathogen NNS cord-345211-4ivqlsgt 187 20 from from IN cord-345211-4ivqlsgt 187 21 colonizing colonize VBG cord-345211-4ivqlsgt 187 22 microorganisms microorganism NNS cord-345211-4ivqlsgt 187 23 and and CC cord-345211-4ivqlsgt 187 24 as as IN cord-345211-4ivqlsgt 187 25 a a DT cord-345211-4ivqlsgt 187 26 prognostic prognostic JJ cord-345211-4ivqlsgt 187 27 marker marker NN cord-345211-4ivqlsgt 187 28 . . . cord-345211-4ivqlsgt 188 1 It -PRON- PRP cord-345211-4ivqlsgt 188 2 is be VBZ cord-345211-4ivqlsgt 188 3 still still RB cord-345211-4ivqlsgt 188 4 unclear unclear JJ cord-345211-4ivqlsgt 188 5 about about IN cord-345211-4ivqlsgt 188 6 how how WRB cord-345211-4ivqlsgt 188 7 new new JJ cord-345211-4ivqlsgt 188 8 knowledge knowledge NN cord-345211-4ivqlsgt 188 9 about about IN cord-345211-4ivqlsgt 188 10 the the DT cord-345211-4ivqlsgt 188 11 lung lung NN cord-345211-4ivqlsgt 188 12 microbiome microbiome NN cord-345211-4ivqlsgt 188 13 will will MD cord-345211-4ivqlsgt 188 14 affect affect VB cord-345211-4ivqlsgt 188 15 the the DT cord-345211-4ivqlsgt 188 16 development development NN cord-345211-4ivqlsgt 188 17 of of IN cord-345211-4ivqlsgt 188 18 pneumonia pneumonia NN cord-345211-4ivqlsgt 188 19 diagnostics diagnostic NNS cord-345211-4ivqlsgt 188 20 , , , cord-345211-4ivqlsgt 188 21 but but CC cord-345211-4ivqlsgt 188 22 the the DT cord-345211-4ivqlsgt 188 23 impact impact NN cord-345211-4ivqlsgt 188 24 may may MD cord-345211-4ivqlsgt 188 25 be be VB cord-345211-4ivqlsgt 188 26 profound profound JJ cord-345211-4ivqlsgt 188 27 . . . cord-345211-4ivqlsgt 189 1 While while IN cord-345211-4ivqlsgt 189 2 it -PRON- PRP cord-345211-4ivqlsgt 189 3 will will MD cord-345211-4ivqlsgt 189 4 be be VB cord-345211-4ivqlsgt 189 5 some some DT cord-345211-4ivqlsgt 189 6 time time NN cord-345211-4ivqlsgt 189 7 before before IN cord-345211-4ivqlsgt 189 8 next next JJ cord-345211-4ivqlsgt 189 9 generation generation NN cord-345211-4ivqlsgt 189 10 sequencing sequencing NN cord-345211-4ivqlsgt 189 11 becomes become VBZ cord-345211-4ivqlsgt 189 12 a a DT cord-345211-4ivqlsgt 189 13 standard standard JJ cord-345211-4ivqlsgt 189 14 tool tool NN cord-345211-4ivqlsgt 189 15 in in IN cord-345211-4ivqlsgt 189 16 diagnostic diagnostic JJ cord-345211-4ivqlsgt 189 17 laboratories laboratory NNS cord-345211-4ivqlsgt 189 18 , , , cord-345211-4ivqlsgt 189 19 this this DT cord-345211-4ivqlsgt 189 20 technology technology NN cord-345211-4ivqlsgt 189 21 may may MD cord-345211-4ivqlsgt 189 22 provide provide VB cord-345211-4ivqlsgt 189 23 valuable valuable JJ cord-345211-4ivqlsgt 189 24 insights insight NNS cord-345211-4ivqlsgt 189 25 into into IN cord-345211-4ivqlsgt 189 26 the the DT cord-345211-4ivqlsgt 189 27 lung lung NN cord-345211-4ivqlsgt 189 28 microbial microbial NN cord-345211-4ivqlsgt 189 29 ecology ecology NN cord-345211-4ivqlsgt 189 30 in in IN cord-345211-4ivqlsgt 189 31 health health NN cord-345211-4ivqlsgt 189 32 and and CC cord-345211-4ivqlsgt 189 33 disease disease NN cord-345211-4ivqlsgt 189 34 and and CC cord-345211-4ivqlsgt 189 35 a a DT cord-345211-4ivqlsgt 189 36 greater great JJR cord-345211-4ivqlsgt 189 37 understanding understanding NN cord-345211-4ivqlsgt 189 38 of of IN cord-345211-4ivqlsgt 189 39 the the DT cord-345211-4ivqlsgt 189 40 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 189 41 of of IN cord-345211-4ivqlsgt 189 42 pneumonia pneumonia NN cord-345211-4ivqlsgt 189 43 . . . cord-345211-4ivqlsgt 190 1 With with IN cord-345211-4ivqlsgt 190 2 this this DT cord-345211-4ivqlsgt 190 3 comes come VBZ cord-345211-4ivqlsgt 190 4 a a DT cord-345211-4ivqlsgt 190 5 shift shift NN cord-345211-4ivqlsgt 190 6 away away RB cord-345211-4ivqlsgt 190 7 from from IN cord-345211-4ivqlsgt 190 8 the the DT cord-345211-4ivqlsgt 190 9 targeting targeting NN cord-345211-4ivqlsgt 190 10 of of IN cord-345211-4ivqlsgt 190 11 a a DT cord-345211-4ivqlsgt 190 12 limited limited JJ cord-345211-4ivqlsgt 190 13 number number NN cord-345211-4ivqlsgt 190 14 of of IN cord-345211-4ivqlsgt 190 15 putative putative JJ cord-345211-4ivqlsgt 190 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 190 17 pathogens pathogen NNS cord-345211-4ivqlsgt 190 18 toward toward IN cord-345211-4ivqlsgt 190 19 the the DT cord-345211-4ivqlsgt 190 20 identification identification NN cord-345211-4ivqlsgt 190 21 of of IN cord-345211-4ivqlsgt 190 22 signal signal NN cord-345211-4ivqlsgt 190 23 patterns pattern NNS cord-345211-4ivqlsgt 190 24 characteristic characteristic JJ cord-345211-4ivqlsgt 190 25 of of IN cord-345211-4ivqlsgt 190 26 different different JJ cord-345211-4ivqlsgt 190 27 etiologies etiology NNS cord-345211-4ivqlsgt 190 28 and and CC cord-345211-4ivqlsgt 190 29 stages stage NNS cord-345211-4ivqlsgt 190 30 of of IN cord-345211-4ivqlsgt 190 31 pneumonia pneumonia NN cord-345211-4ivqlsgt 190 32 . . . cord-345211-4ivqlsgt 191 1 The the DT cord-345211-4ivqlsgt 191 2 hope hope NN cord-345211-4ivqlsgt 191 3 is be VBZ cord-345211-4ivqlsgt 191 4 that that IN cord-345211-4ivqlsgt 191 5 these these DT cord-345211-4ivqlsgt 191 6 signals signal NNS cord-345211-4ivqlsgt 191 7 will will MD cord-345211-4ivqlsgt 191 8 have have VB cord-345211-4ivqlsgt 191 9 sufficient sufficient JJ cord-345211-4ivqlsgt 191 10 diagnostic diagnostic JJ cord-345211-4ivqlsgt 191 11 accuracy accuracy NN cord-345211-4ivqlsgt 191 12 to to TO cord-345211-4ivqlsgt 191 13 help help VB cord-345211-4ivqlsgt 191 14 guide guide VB cord-345211-4ivqlsgt 191 15 pneumonia pneumonia NN cord-345211-4ivqlsgt 191 16 management management NN cord-345211-4ivqlsgt 191 17 . . . cord-345211-4ivqlsgt 192 1 The the DT cord-345211-4ivqlsgt 192 2 author author NN cord-345211-4ivqlsgt 192 3 has have VBZ cord-345211-4ivqlsgt 192 4 no no DT cord-345211-4ivqlsgt 192 5 relevant relevant JJ cord-345211-4ivqlsgt 192 6 affiliations affiliation NNS cord-345211-4ivqlsgt 192 7 or or CC cord-345211-4ivqlsgt 192 8 financial financial JJ cord-345211-4ivqlsgt 192 9 involvement involvement NN cord-345211-4ivqlsgt 192 10 with with IN cord-345211-4ivqlsgt 192 11 any any DT cord-345211-4ivqlsgt 192 12 organization organization NN cord-345211-4ivqlsgt 192 13 or or CC cord-345211-4ivqlsgt 192 14 entity entity NN cord-345211-4ivqlsgt 192 15 with with IN cord-345211-4ivqlsgt 192 16 a a DT cord-345211-4ivqlsgt 192 17 financial financial JJ cord-345211-4ivqlsgt 192 18 interest interest NN cord-345211-4ivqlsgt 192 19 in in IN cord-345211-4ivqlsgt 192 20 or or CC cord-345211-4ivqlsgt 192 21 financial financial JJ cord-345211-4ivqlsgt 192 22 conflict conflict NN cord-345211-4ivqlsgt 192 23 with with IN cord-345211-4ivqlsgt 192 24 the the DT cord-345211-4ivqlsgt 192 25 subject subject JJ cord-345211-4ivqlsgt 192 26 matter matter NN cord-345211-4ivqlsgt 192 27 or or CC cord-345211-4ivqlsgt 192 28 materials material NNS cord-345211-4ivqlsgt 192 29 discussed discuss VBN cord-345211-4ivqlsgt 192 30 in in IN cord-345211-4ivqlsgt 192 31 the the DT cord-345211-4ivqlsgt 192 32 manuscript manuscript NN cord-345211-4ivqlsgt 192 33 . . . cord-345211-4ivqlsgt 193 1 This this DT cord-345211-4ivqlsgt 193 2 includes include VBZ cord-345211-4ivqlsgt 193 3 employment employment NN cord-345211-4ivqlsgt 193 4 , , , cord-345211-4ivqlsgt 193 5 consultancies consultancy NNS cord-345211-4ivqlsgt 193 6 , , , cord-345211-4ivqlsgt 193 7 honoraria honorarium NNS cord-345211-4ivqlsgt 193 8 , , , cord-345211-4ivqlsgt 193 9 stock stock NN cord-345211-4ivqlsgt 193 10 ownership ownership NN cord-345211-4ivqlsgt 193 11 or or CC cord-345211-4ivqlsgt 193 12 options option NNS cord-345211-4ivqlsgt 193 13 , , , cord-345211-4ivqlsgt 193 14 expert expert JJ cord-345211-4ivqlsgt 193 15 testimony testimony NN cord-345211-4ivqlsgt 193 16 , , , cord-345211-4ivqlsgt 193 17 grants grant NNS cord-345211-4ivqlsgt 193 18 or or CC cord-345211-4ivqlsgt 193 19 patents patent NNS cord-345211-4ivqlsgt 193 20 received receive VBN cord-345211-4ivqlsgt 193 21 or or CC cord-345211-4ivqlsgt 193 22 pending pende VBG cord-345211-4ivqlsgt 193 23 , , , cord-345211-4ivqlsgt 193 24 or or CC cord-345211-4ivqlsgt 193 25 royalties royalty NNS cord-345211-4ivqlsgt 193 26 . . . cord-345211-4ivqlsgt 194 1 • • NNP cord-345211-4ivqlsgt 195 1 Identifying identify VBG cord-345211-4ivqlsgt 195 2 the the DT cord-345211-4ivqlsgt 195 3 microbial microbial JJ cord-345211-4ivqlsgt 195 4 etiology etiology NN cord-345211-4ivqlsgt 195 5 of of IN cord-345211-4ivqlsgt 195 6 pneumonia pneumonia NN cord-345211-4ivqlsgt 195 7 is be VBZ cord-345211-4ivqlsgt 195 8 challenging challenging JJ cord-345211-4ivqlsgt 195 9 , , , cord-345211-4ivqlsgt 195 10 largely largely RB cord-345211-4ivqlsgt 195 11 due due JJ cord-345211-4ivqlsgt 195 12 to to IN cord-345211-4ivqlsgt 195 13 difficulty difficulty NN cord-345211-4ivqlsgt 195 14 in in IN cord-345211-4ivqlsgt 195 15 obtaining obtain VBG cord-345211-4ivqlsgt 195 16 uncontaminated uncontaminated JJ cord-345211-4ivqlsgt 195 17 specimens specimen NNS cord-345211-4ivqlsgt 195 18 from from IN cord-345211-4ivqlsgt 195 19 the the DT cord-345211-4ivqlsgt 195 20 site site NN cord-345211-4ivqlsgt 195 21 of of IN cord-345211-4ivqlsgt 195 22 infection infection NN cord-345211-4ivqlsgt 195 23 and and CC cord-345211-4ivqlsgt 195 24 in in IN cord-345211-4ivqlsgt 195 25 discriminating discriminate VBG cord-345211-4ivqlsgt 195 26 between between IN cord-345211-4ivqlsgt 195 27 colonizing colonize VBG cord-345211-4ivqlsgt 195 28 microorganisms microorganism NNS cord-345211-4ivqlsgt 195 29 and and CC cord-345211-4ivqlsgt 195 30 true true JJ cord-345211-4ivqlsgt 195 31 pathogens pathogen NNS cord-345211-4ivqlsgt 195 32 . . . cord-345211-4ivqlsgt 196 1 • • NNP cord-345211-4ivqlsgt 197 1 Molecular molecular JJ cord-345211-4ivqlsgt 197 2 tests test NNS cord-345211-4ivqlsgt 197 3 , , , cord-345211-4ivqlsgt 197 4 particularly particularly RB cord-345211-4ivqlsgt 197 5 NATs NATs NNP cord-345211-4ivqlsgt 197 6 , , , cord-345211-4ivqlsgt 197 7 have have VBP cord-345211-4ivqlsgt 197 8 been be VBN cord-345211-4ivqlsgt 197 9 the the DT cord-345211-4ivqlsgt 197 10 major major JJ cord-345211-4ivqlsgt 197 11 advance advance NN cord-345211-4ivqlsgt 197 12 in in IN cord-345211-4ivqlsgt 197 13 pneumonia pneumonia NN cord-345211-4ivqlsgt 197 14 diagnostics diagnostic NNS cord-345211-4ivqlsgt 197 15 over over IN cord-345211-4ivqlsgt 197 16 recent recent JJ cord-345211-4ivqlsgt 197 17 years year NNS cord-345211-4ivqlsgt 197 18 . . . cord-345211-4ivqlsgt 198 1 • • NNP cord-345211-4ivqlsgt 198 2 Although although IN cord-345211-4ivqlsgt 198 3 uptake uptake NN cord-345211-4ivqlsgt 198 4 has have VBZ cord-345211-4ivqlsgt 198 5 been be VBN cord-345211-4ivqlsgt 198 6 relatively relatively RB cord-345211-4ivqlsgt 198 7 slow slow JJ cord-345211-4ivqlsgt 198 8 , , , cord-345211-4ivqlsgt 198 9 NATs NATs NNP cord-345211-4ivqlsgt 198 10 now now RB cord-345211-4ivqlsgt 198 11 have have VBP cord-345211-4ivqlsgt 198 12 established establish VBN cord-345211-4ivqlsgt 198 13 roles role NNS cord-345211-4ivqlsgt 198 14 ( ( -LRB- cord-345211-4ivqlsgt 198 15 often often RB cord-345211-4ivqlsgt 198 16 as as IN cord-345211-4ivqlsgt 198 17 the the DT cord-345211-4ivqlsgt 198 18 diagnostic diagnostic NN cord-345211-4ivqlsgt 198 19 of of IN cord-345211-4ivqlsgt 198 20 choice choice NN cord-345211-4ivqlsgt 198 21 ) ) -RRB- cord-345211-4ivqlsgt 198 22 for for IN cord-345211-4ivqlsgt 198 23 the the DT cord-345211-4ivqlsgt 198 24 detection detection NN cord-345211-4ivqlsgt 198 25 of of IN cord-345211-4ivqlsgt 198 26 respiratory respiratory JJ cord-345211-4ivqlsgt 198 27 viruses virus NNS cord-345211-4ivqlsgt 198 28 and and CC cord-345211-4ivqlsgt 198 29 several several JJ cord-345211-4ivqlsgt 198 30 non non JJ cord-345211-4ivqlsgt 198 31 - - JJ cord-345211-4ivqlsgt 198 32 colonizing colonizing JJ cord-345211-4ivqlsgt 198 33 bacteria bacteria NNS cord-345211-4ivqlsgt 198 34 ( ( -LRB- cord-345211-4ivqlsgt 198 35 e.g. e.g. RB cord-345211-4ivqlsgt 198 36 Legionella Legionella NNP cord-345211-4ivqlsgt 198 37 species specie NNS cord-345211-4ivqlsgt 198 38 ) ) -RRB- cord-345211-4ivqlsgt 198 39 . . . cord-345211-4ivqlsgt 199 1 In in IN cord-345211-4ivqlsgt 199 2 contrast contrast NN cord-345211-4ivqlsgt 199 3 , , , cord-345211-4ivqlsgt 199 4 NATs NATs NNP cord-345211-4ivqlsgt 199 5 have have VBP cord-345211-4ivqlsgt 199 6 yet yet RB cord-345211-4ivqlsgt 199 7 to to TO cord-345211-4ivqlsgt 199 8 have have VB cord-345211-4ivqlsgt 199 9 an an DT cord-345211-4ivqlsgt 199 10 established establish VBN cord-345211-4ivqlsgt 199 11 role role NN cord-345211-4ivqlsgt 199 12 for for IN cord-345211-4ivqlsgt 199 13 several several JJ cord-345211-4ivqlsgt 199 14 important important JJ cord-345211-4ivqlsgt 199 15 bacterial bacterial JJ cord-345211-4ivqlsgt 199 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 199 17 pathogens pathogen NNS cord-345211-4ivqlsgt 199 18 ( ( -LRB- cord-345211-4ivqlsgt 199 19 e.g. e.g. RB cord-345211-4ivqlsgt 199 20 S. S. NNP cord-345211-4ivqlsgt 199 21 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 199 22 ) ) -RRB- cord-345211-4ivqlsgt 199 23 that that WDT cord-345211-4ivqlsgt 199 24 also also RB cord-345211-4ivqlsgt 199 25 are be VBP cord-345211-4ivqlsgt 199 26 asymptomatic asymptomatic JJ cord-345211-4ivqlsgt 199 27 colonizers colonizer NNS cord-345211-4ivqlsgt 199 28 of of IN cord-345211-4ivqlsgt 199 29 the the DT cord-345211-4ivqlsgt 199 30 upper upper JJ cord-345211-4ivqlsgt 199 31 respiratory respiratory JJ cord-345211-4ivqlsgt 199 32 tract tract NN cord-345211-4ivqlsgt 199 33 . . . cord-345211-4ivqlsgt 200 1 • • NNP cord-345211-4ivqlsgt 201 1 Further further JJ cord-345211-4ivqlsgt 201 2 developments development NNS cord-345211-4ivqlsgt 201 3 in in IN cord-345211-4ivqlsgt 201 4 molecular molecular JJ cord-345211-4ivqlsgt 201 5 tests test NNS cord-345211-4ivqlsgt 201 6 need need VBP cord-345211-4ivqlsgt 201 7 to to TO cord-345211-4ivqlsgt 201 8 focus focus VB cord-345211-4ivqlsgt 201 9 on on IN cord-345211-4ivqlsgt 201 10 methods method NNS cord-345211-4ivqlsgt 201 11 to to TO cord-345211-4ivqlsgt 201 12 help help VB cord-345211-4ivqlsgt 201 13 interpret interpret VB cord-345211-4ivqlsgt 201 14 the the DT cord-345211-4ivqlsgt 201 15 significance significance NN cord-345211-4ivqlsgt 201 16 of of IN cord-345211-4ivqlsgt 201 17 positive positive JJ cord-345211-4ivqlsgt 201 18 results result NNS cord-345211-4ivqlsgt 201 19 . . . cord-345211-4ivqlsgt 202 1 The the DT cord-345211-4ivqlsgt 202 2 use use NN cord-345211-4ivqlsgt 202 3 of of IN cord-345211-4ivqlsgt 202 4 quantitative quantitative JJ cord-345211-4ivqlsgt 202 5 NATs nat NNS cord-345211-4ivqlsgt 202 6 and and CC cord-345211-4ivqlsgt 202 7 microbial microbial JJ cord-345211-4ivqlsgt 202 8 load load NN cord-345211-4ivqlsgt 202 9 cutoffs cutoff NNS cord-345211-4ivqlsgt 202 10 has have VBZ cord-345211-4ivqlsgt 202 11 shown show VBN cord-345211-4ivqlsgt 202 12 promise promise NN cord-345211-4ivqlsgt 202 13 as as IN cord-345211-4ivqlsgt 202 14 one one CD cord-345211-4ivqlsgt 202 15 means mean VBZ cord-345211-4ivqlsgt 202 16 to to TO cord-345211-4ivqlsgt 202 17 discriminate discriminate VB cord-345211-4ivqlsgt 202 18 between between IN cord-345211-4ivqlsgt 202 19 colonizing colonize VBG cord-345211-4ivqlsgt 202 20 and and CC cord-345211-4ivqlsgt 202 21 pathogenic pathogenic JJ cord-345211-4ivqlsgt 202 22 microorganisms microorganism NNS cord-345211-4ivqlsgt 202 23 . . . cord-345211-4ivqlsgt 203 1 • • NNP cord-345211-4ivqlsgt 204 1 The the DT cord-345211-4ivqlsgt 204 2 recent recent JJ cord-345211-4ivqlsgt 204 3 revelation revelation NN cord-345211-4ivqlsgt 204 4 that that IN cord-345211-4ivqlsgt 204 5 the the DT cord-345211-4ivqlsgt 204 6 lung lung NN cord-345211-4ivqlsgt 204 7 microbiome microbiome NN cord-345211-4ivqlsgt 204 8 exists exist VBZ cord-345211-4ivqlsgt 204 9 and and CC cord-345211-4ivqlsgt 204 10 new new JJ cord-345211-4ivqlsgt 204 11 knowledge knowledge NN cord-345211-4ivqlsgt 204 12 about about IN cord-345211-4ivqlsgt 204 13 the the DT cord-345211-4ivqlsgt 204 14 interaction interaction NN cord-345211-4ivqlsgt 204 15 between between IN cord-345211-4ivqlsgt 204 16 bacteria bacteria NNS cord-345211-4ivqlsgt 204 17 and and CC cord-345211-4ivqlsgt 204 18 viruses virus NNS cord-345211-4ivqlsgt 204 19 has have VBZ cord-345211-4ivqlsgt 204 20 changed change VBN cord-345211-4ivqlsgt 204 21 the the DT cord-345211-4ivqlsgt 204 22 traditional traditional JJ cord-345211-4ivqlsgt 204 23 view view NN cord-345211-4ivqlsgt 204 24 of of IN cord-345211-4ivqlsgt 204 25 pneumonia pneumonia NN cord-345211-4ivqlsgt 204 26 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 204 27 . . . cord-345211-4ivqlsgt 205 1 New new JJ cord-345211-4ivqlsgt 205 2 diagnostics diagnostic NNS cord-345211-4ivqlsgt 205 3 need need VBP cord-345211-4ivqlsgt 205 4 to to TO cord-345211-4ivqlsgt 205 5 account account VB cord-345211-4ivqlsgt 205 6 for for IN cord-345211-4ivqlsgt 205 7 this this DT cord-345211-4ivqlsgt 205 8 new new JJ cord-345211-4ivqlsgt 205 9 paradigm paradigm NN cord-345211-4ivqlsgt 205 10 and and CC cord-345211-4ivqlsgt 205 11 be be VB cord-345211-4ivqlsgt 205 12 less less RBR cord-345211-4ivqlsgt 205 13 focused focused JJ cord-345211-4ivqlsgt 205 14 on on IN cord-345211-4ivqlsgt 205 15 just just RB cord-345211-4ivqlsgt 205 16 detecting detect VBG cord-345211-4ivqlsgt 205 17 specific specific JJ cord-345211-4ivqlsgt 205 18 known know VBN cord-345211-4ivqlsgt 205 19 pathogens pathogen NNS cord-345211-4ivqlsgt 205 20 . . . cord-345211-4ivqlsgt 206 1 Global global JJ cord-345211-4ivqlsgt 206 2 , , , cord-345211-4ivqlsgt 206 3 regional regional JJ cord-345211-4ivqlsgt 206 4 , , , cord-345211-4ivqlsgt 206 5 and and CC cord-345211-4ivqlsgt 206 6 national national JJ cord-345211-4ivqlsgt 206 7 incidence incidence NN cord-345211-4ivqlsgt 206 8 , , , cord-345211-4ivqlsgt 206 9 prevalence prevalence NN cord-345211-4ivqlsgt 206 10 , , , cord-345211-4ivqlsgt 206 11 and and CC cord-345211-4ivqlsgt 206 12 years year NNS cord-345211-4ivqlsgt 206 13 lived live VBD cord-345211-4ivqlsgt 206 14 with with IN cord-345211-4ivqlsgt 206 15 disability disability NN cord-345211-4ivqlsgt 206 16 for for IN cord-345211-4ivqlsgt 206 17 301 301 CD cord-345211-4ivqlsgt 206 18 acute acute JJ cord-345211-4ivqlsgt 206 19 and and CC cord-345211-4ivqlsgt 206 20 chronic chronic JJ cord-345211-4ivqlsgt 206 21 diseases disease NNS cord-345211-4ivqlsgt 206 22 and and CC cord-345211-4ivqlsgt 206 23 injuries injury NNS cord-345211-4ivqlsgt 206 24 in in IN cord-345211-4ivqlsgt 206 25 188 188 CD cord-345211-4ivqlsgt 206 26 countries country NNS cord-345211-4ivqlsgt 206 27 , , , cord-345211-4ivqlsgt 206 28 1990 1990 CD cord-345211-4ivqlsgt 206 29 - - SYM cord-345211-4ivqlsgt 206 30 2013 2013 CD cord-345211-4ivqlsgt 206 31 : : : cord-345211-4ivqlsgt 206 32 a a DT cord-345211-4ivqlsgt 206 33 systematic systematic JJ cord-345211-4ivqlsgt 206 34 analysis analysis NN cord-345211-4ivqlsgt 206 35 for for IN cord-345211-4ivqlsgt 206 36 the the DT cord-345211-4ivqlsgt 206 37 global global JJ cord-345211-4ivqlsgt 206 38 burden burden NN cord-345211-4ivqlsgt 206 39 of of IN cord-345211-4ivqlsgt 206 40 disease disease NN cord-345211-4ivqlsgt 206 41 study study NN cord-345211-4ivqlsgt 206 42 2013 2013 CD cord-345211-4ivqlsgt 206 43 Global global JJ cord-345211-4ivqlsgt 206 44 burden burden NN cord-345211-4ivqlsgt 206 45 of of IN cord-345211-4ivqlsgt 206 46 childhood childhood NN cord-345211-4ivqlsgt 206 47 pneumonia pneumonia NN cord-345211-4ivqlsgt 206 48 and and CC cord-345211-4ivqlsgt 206 49 diarrhoea diarrhoea NN cord-345211-4ivqlsgt 207 1 Community community NN cord-345211-4ivqlsgt 207 2 - - HYPH cord-345211-4ivqlsgt 207 3 acquired acquire VBN cord-345211-4ivqlsgt 207 4 pneumonia pneumonia NN cord-345211-4ivqlsgt 207 5 Breathing breathe VBG cord-345211-4ivqlsgt 207 6 new new JJ cord-345211-4ivqlsgt 207 7 life life NN cord-345211-4ivqlsgt 207 8 into into IN cord-345211-4ivqlsgt 207 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 207 10 diagnostics diagnostic NNS cord-345211-4ivqlsgt 208 1 This this DT cord-345211-4ivqlsgt 208 2 commentary commentary NN cord-345211-4ivqlsgt 208 3 summarizes summarize VBZ cord-345211-4ivqlsgt 208 4 some some DT cord-345211-4ivqlsgt 208 5 of of IN cord-345211-4ivqlsgt 208 6 the the DT cord-345211-4ivqlsgt 208 7 key key JJ cord-345211-4ivqlsgt 208 8 challenges challenge NNS cord-345211-4ivqlsgt 208 9 in in IN cord-345211-4ivqlsgt 208 10 determining determine VBG cord-345211-4ivqlsgt 208 11 the the DT cord-345211-4ivqlsgt 208 12 microbial microbial JJ cord-345211-4ivqlsgt 208 13 etiology etiology NN cord-345211-4ivqlsgt 208 14 of of IN cord-345211-4ivqlsgt 208 15 pneumonia pneumonia NN cord-345211-4ivqlsgt 208 16 Laboratory laboratory NN cord-345211-4ivqlsgt 208 17 methods method NNS cord-345211-4ivqlsgt 208 18 for for IN cord-345211-4ivqlsgt 208 19 determining determine VBG cord-345211-4ivqlsgt 208 20 pneumonia pneumonia NN cord-345211-4ivqlsgt 208 21 etiology etiology NN cord-345211-4ivqlsgt 208 22 in in IN cord-345211-4ivqlsgt 208 23 children child NNS cord-345211-4ivqlsgt 208 24 Vaccine vaccine NN cord-345211-4ivqlsgt 208 25 effects effect NNS cord-345211-4ivqlsgt 208 26 and and CC cord-345211-4ivqlsgt 208 27 impact impact NN cord-345211-4ivqlsgt 208 28 of of IN cord-345211-4ivqlsgt 208 29 vaccination vaccination NN cord-345211-4ivqlsgt 208 30 programmes programme NNS cord-345211-4ivqlsgt 208 31 in in IN cord-345211-4ivqlsgt 208 32 post post JJ cord-345211-4ivqlsgt 208 33 - - JJ cord-345211-4ivqlsgt 208 34 licensure licensure JJ cord-345211-4ivqlsgt 208 35 studies study NNS cord-345211-4ivqlsgt 209 1 Transthoracic Transthoracic NNP cord-345211-4ivqlsgt 209 2 lung lung NN cord-345211-4ivqlsgt 209 3 aspiration aspiration NN cord-345211-4ivqlsgt 209 4 for for IN cord-345211-4ivqlsgt 209 5 the the DT cord-345211-4ivqlsgt 209 6 aetiological aetiological JJ cord-345211-4ivqlsgt 209 7 diagnosis diagnosis NN cord-345211-4ivqlsgt 209 8 of of IN cord-345211-4ivqlsgt 209 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 209 10 : : : cord-345211-4ivqlsgt 210 1 25 25 CD cord-345211-4ivqlsgt 210 2 years year NNS cord-345211-4ivqlsgt 210 3 of of IN cord-345211-4ivqlsgt 210 4 experience experience NN cord-345211-4ivqlsgt 210 5 from from IN cord-345211-4ivqlsgt 210 6 The the DT cord-345211-4ivqlsgt 210 7 Gambia Gambia NNP cord-345211-4ivqlsgt 210 8 BTS BTS NNP cord-345211-4ivqlsgt 210 9 guidelines guideline NNS cord-345211-4ivqlsgt 210 10 for for IN cord-345211-4ivqlsgt 210 11 the the DT cord-345211-4ivqlsgt 210 12 management management NN cord-345211-4ivqlsgt 210 13 of of IN cord-345211-4ivqlsgt 210 14 community community NN cord-345211-4ivqlsgt 210 15 acquired acquire VBD cord-345211-4ivqlsgt 210 16 pneumonia pneumonia NN cord-345211-4ivqlsgt 210 17 in in IN cord-345211-4ivqlsgt 210 18 adults adult NNS cord-345211-4ivqlsgt 210 19 : : : cord-345211-4ivqlsgt 210 20 update update VB cord-345211-4ivqlsgt 210 21 Infectious infectious JJ cord-345211-4ivqlsgt 210 22 diseases disease NNS cord-345211-4ivqlsgt 210 23 society society NN cord-345211-4ivqlsgt 210 24 of of IN cord-345211-4ivqlsgt 210 25 America America NNP cord-345211-4ivqlsgt 210 26 / / SYM cord-345211-4ivqlsgt 210 27 American american JJ cord-345211-4ivqlsgt 210 28 thoracic thoracic JJ cord-345211-4ivqlsgt 210 29 society society NN cord-345211-4ivqlsgt 210 30 consensus consensus NN cord-345211-4ivqlsgt 210 31 guidelines guideline NNS cord-345211-4ivqlsgt 210 32 on on IN cord-345211-4ivqlsgt 210 33 the the DT cord-345211-4ivqlsgt 210 34 management management NN cord-345211-4ivqlsgt 210 35 of of IN cord-345211-4ivqlsgt 210 36 community community NN cord-345211-4ivqlsgt 210 37 - - HYPH cord-345211-4ivqlsgt 210 38 acquired acquire VBN cord-345211-4ivqlsgt 210 39 pneumonia pneumonia NN cord-345211-4ivqlsgt 210 40 in in IN cord-345211-4ivqlsgt 210 41 adults adult NNS cord-345211-4ivqlsgt 210 42 Pneumonia Pneumonia NNP cord-345211-4ivqlsgt 210 43 in in IN cord-345211-4ivqlsgt 210 44 adults adult NNS cord-345211-4ivqlsgt 210 45 : : : cord-345211-4ivqlsgt 210 46 diagnosis diagnosis NN cord-345211-4ivqlsgt 210 47 and and CC cord-345211-4ivqlsgt 210 48 management management NN cord-345211-4ivqlsgt 210 49 . . . cord-345211-4ivqlsgt 211 1 Manchester Manchester NNP cord-345211-4ivqlsgt 211 2 : : : cord-345211-4ivqlsgt 212 1 National National NNP cord-345211-4ivqlsgt 212 2 Institute Institute NNP cord-345211-4ivqlsgt 212 3 for for IN cord-345211-4ivqlsgt 212 4 Health Health NNP cord-345211-4ivqlsgt 212 5 and and CC cord-345211-4ivqlsgt 212 6 Care Care NNP cord-345211-4ivqlsgt 212 7 Excellence Excellence NNP cord-345211-4ivqlsgt 213 1 The the DT cord-345211-4ivqlsgt 213 2 management management NN cord-345211-4ivqlsgt 213 3 of of IN cord-345211-4ivqlsgt 213 4 community community NN cord-345211-4ivqlsgt 213 5 - - HYPH cord-345211-4ivqlsgt 213 6 acquired acquire VBN cord-345211-4ivqlsgt 213 7 pneumonia pneumonia NN cord-345211-4ivqlsgt 213 8 in in IN cord-345211-4ivqlsgt 213 9 infants infant NNS cord-345211-4ivqlsgt 213 10 and and CC cord-345211-4ivqlsgt 213 11 children child NNS cord-345211-4ivqlsgt 213 12 older old JJR cord-345211-4ivqlsgt 213 13 than than IN cord-345211-4ivqlsgt 213 14 3 3 CD cord-345211-4ivqlsgt 213 15 months month NNS cord-345211-4ivqlsgt 213 16 of of IN cord-345211-4ivqlsgt 213 17 age age NN cord-345211-4ivqlsgt 213 18 : : : cord-345211-4ivqlsgt 213 19 clinical clinical JJ cord-345211-4ivqlsgt 213 20 practice practice NN cord-345211-4ivqlsgt 213 21 guidelines guideline NNS cord-345211-4ivqlsgt 213 22 by by IN cord-345211-4ivqlsgt 213 23 the the DT cord-345211-4ivqlsgt 213 24 Pediatric pediatric JJ cord-345211-4ivqlsgt 213 25 infectious infectious JJ cord-345211-4ivqlsgt 213 26 diseases disease NNS cord-345211-4ivqlsgt 213 27 society society NN cord-345211-4ivqlsgt 213 28 and and CC cord-345211-4ivqlsgt 213 29 the the DT cord-345211-4ivqlsgt 213 30 infectious infectious JJ cord-345211-4ivqlsgt 213 31 diseases disease NNS cord-345211-4ivqlsgt 213 32 society society NN cord-345211-4ivqlsgt 213 33 of of IN cord-345211-4ivqlsgt 213 34 America America NNP cord-345211-4ivqlsgt 213 35 British British NNP cord-345211-4ivqlsgt 213 36 Thoracic Thoracic NNP cord-345211-4ivqlsgt 213 37 Society Society NNP cord-345211-4ivqlsgt 213 38 guidelines guideline NNS cord-345211-4ivqlsgt 213 39 for for IN cord-345211-4ivqlsgt 213 40 the the DT cord-345211-4ivqlsgt 213 41 management management NN cord-345211-4ivqlsgt 213 42 of of IN cord-345211-4ivqlsgt 213 43 community community NN cord-345211-4ivqlsgt 213 44 acquired acquire VBD cord-345211-4ivqlsgt 213 45 pneumonia pneumonia NN cord-345211-4ivqlsgt 213 46 in in IN cord-345211-4ivqlsgt 213 47 children child NNS cord-345211-4ivqlsgt 213 48 : : : cord-345211-4ivqlsgt 213 49 update update VB cord-345211-4ivqlsgt 213 50 Rapid Rapid NNP cord-345211-4ivqlsgt 213 51 identification identification NN cord-345211-4ivqlsgt 213 52 of of IN cord-345211-4ivqlsgt 213 53 pathogens pathogen NNS cord-345211-4ivqlsgt 213 54 using use VBG cord-345211-4ivqlsgt 213 55 molecular molecular JJ cord-345211-4ivqlsgt 213 56 techniques technique NNS cord-345211-4ivqlsgt 213 57 Development development NN cord-345211-4ivqlsgt 213 58 and and CC cord-345211-4ivqlsgt 213 59 deployment deployment NN cord-345211-4ivqlsgt 213 60 of of IN cord-345211-4ivqlsgt 213 61 a a DT cord-345211-4ivqlsgt 213 62 rapid rapid JJ cord-345211-4ivqlsgt 213 63 recombinase recombinase NN cord-345211-4ivqlsgt 213 64 polymerase polymerase NN cord-345211-4ivqlsgt 213 65 amplification amplification NN cord-345211-4ivqlsgt 213 66 Ebola Ebola NNP cord-345211-4ivqlsgt 213 67 virus virus NN cord-345211-4ivqlsgt 213 68 detection detection NN cord-345211-4ivqlsgt 213 69 assay assay NN cord-345211-4ivqlsgt 213 70 in in IN cord-345211-4ivqlsgt 213 71 Guinea Guinea NNP cord-345211-4ivqlsgt 213 72 in in IN cord-345211-4ivqlsgt 213 73 2015 2015 CD cord-345211-4ivqlsgt 213 74 Update update NN cord-345211-4ivqlsgt 213 75 on on IN cord-345211-4ivqlsgt 213 76 influenza influenza NN cord-345211-4ivqlsgt 213 77 diagnostics diagnostic NNS cord-345211-4ivqlsgt 213 78 : : : cord-345211-4ivqlsgt 214 1 lessons lesson NNS cord-345211-4ivqlsgt 214 2 from from IN cord-345211-4ivqlsgt 214 3 the the DT cord-345211-4ivqlsgt 214 4 novel novel NN cord-345211-4ivqlsgt 215 1 H1N1 H1N1 NNP cord-345211-4ivqlsgt 215 2 influenza influenza NN cord-345211-4ivqlsgt 215 3 A a DT cord-345211-4ivqlsgt 215 4 pandemic pandemic NN cord-345211-4ivqlsgt 215 5 MERS MERS NNP cord-345211-4ivqlsgt 215 6 coronavirus coronavirus NN cord-345211-4ivqlsgt 215 7 : : : cord-345211-4ivqlsgt 215 8 diagnostics diagnostic NNS cord-345211-4ivqlsgt 215 9 , , , cord-345211-4ivqlsgt 215 10 epidemiology epidemiology NN cord-345211-4ivqlsgt 215 11 and and CC cord-345211-4ivqlsgt 215 12 transmission transmission NN cord-345211-4ivqlsgt 216 1 Nucleic nucleic JJ cord-345211-4ivqlsgt 216 2 acid acid NN cord-345211-4ivqlsgt 216 3 amplification amplification NN cord-345211-4ivqlsgt 216 4 tests test NNS cord-345211-4ivqlsgt 216 5 for for IN cord-345211-4ivqlsgt 216 6 the the DT cord-345211-4ivqlsgt 216 7 diagnosis diagnosis NN cord-345211-4ivqlsgt 216 8 of of IN cord-345211-4ivqlsgt 216 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 216 10 Molecular molecular JJ cord-345211-4ivqlsgt 216 11 genetic genetic JJ cord-345211-4ivqlsgt 216 12 methods method NNS cord-345211-4ivqlsgt 216 13 in in IN cord-345211-4ivqlsgt 216 14 the the DT cord-345211-4ivqlsgt 216 15 diagnosis diagnosis NN cord-345211-4ivqlsgt 216 16 of of IN cord-345211-4ivqlsgt 216 17 lower low JJR cord-345211-4ivqlsgt 216 18 respiratory respiratory JJ cord-345211-4ivqlsgt 216 19 tract tract NN cord-345211-4ivqlsgt 216 20 infections infection NNS cord-345211-4ivqlsgt 216 21 Molecular molecular JJ cord-345211-4ivqlsgt 216 22 diagnosis diagnosis NN cord-345211-4ivqlsgt 216 23 of of IN cord-345211-4ivqlsgt 216 24 respiratory respiratory JJ cord-345211-4ivqlsgt 216 25 viruses virus NNS cord-345211-4ivqlsgt 216 26 Nucleic nucleic IN cord-345211-4ivqlsgt 216 27 acid acid NN cord-345211-4ivqlsgt 216 28 amplification amplification NN cord-345211-4ivqlsgt 216 29 - - HYPH cord-345211-4ivqlsgt 216 30 based base VBN cord-345211-4ivqlsgt 216 31 diagnosis diagnosis NN cord-345211-4ivqlsgt 216 32 of of IN cord-345211-4ivqlsgt 216 33 respiratory respiratory JJ cord-345211-4ivqlsgt 216 34 virus virus NN cord-345211-4ivqlsgt 216 35 infections infection NNS cord-345211-4ivqlsgt 216 36 Viral viral JJ cord-345211-4ivqlsgt 216 37 pneumonia pneumonia NN cord-345211-4ivqlsgt 216 38 Viral viral JJ cord-345211-4ivqlsgt 216 39 infections infection NNS cord-345211-4ivqlsgt 216 40 of of IN cord-345211-4ivqlsgt 216 41 the the DT cord-345211-4ivqlsgt 216 42 lower low JJR cord-345211-4ivqlsgt 216 43 respiratory respiratory JJ cord-345211-4ivqlsgt 216 44 tract tract NN cord-345211-4ivqlsgt 216 45 : : : cord-345211-4ivqlsgt 216 46 old old JJ cord-345211-4ivqlsgt 216 47 viruses virus NNS cord-345211-4ivqlsgt 216 48 , , , cord-345211-4ivqlsgt 216 49 new new JJ cord-345211-4ivqlsgt 216 50 viruses virus NNS cord-345211-4ivqlsgt 216 51 , , , cord-345211-4ivqlsgt 216 52 and and CC cord-345211-4ivqlsgt 216 53 the the DT cord-345211-4ivqlsgt 216 54 role role NN cord-345211-4ivqlsgt 216 55 of of IN cord-345211-4ivqlsgt 216 56 diagnosis diagnosis NN cord-345211-4ivqlsgt 216 57 Point point NN cord-345211-4ivqlsgt 216 58 - - HYPH cord-345211-4ivqlsgt 216 59 counterpoint counterpoint NN cord-345211-4ivqlsgt 216 60 : : : cord-345211-4ivqlsgt 216 61 large large JJ cord-345211-4ivqlsgt 216 62 multiplex multiplex NN cord-345211-4ivqlsgt 216 63 PCR pcr NN cord-345211-4ivqlsgt 216 64 panels panel NNS cord-345211-4ivqlsgt 216 65 should should MD cord-345211-4ivqlsgt 216 66 be be VB cord-345211-4ivqlsgt 216 67 first first JJ cord-345211-4ivqlsgt 216 68 - - HYPH cord-345211-4ivqlsgt 216 69 line line NN cord-345211-4ivqlsgt 216 70 tests test NNS cord-345211-4ivqlsgt 216 71 for for IN cord-345211-4ivqlsgt 216 72 detection detection NN cord-345211-4ivqlsgt 216 73 of of IN cord-345211-4ivqlsgt 216 74 respiratory respiratory JJ cord-345211-4ivqlsgt 216 75 and and CC cord-345211-4ivqlsgt 216 76 intestinal intestinal JJ cord-345211-4ivqlsgt 216 77 pathogens pathogen NNS cord-345211-4ivqlsgt 216 78 A a DT cord-345211-4ivqlsgt 216 79 preliminary preliminary JJ cord-345211-4ivqlsgt 216 80 study study NN cord-345211-4ivqlsgt 216 81 of of IN cord-345211-4ivqlsgt 216 82 pneumonia pneumonia NN cord-345211-4ivqlsgt 216 83 etiology etiology NN cord-345211-4ivqlsgt 216 84 among among IN cord-345211-4ivqlsgt 216 85 hospitalized hospitalize VBN cord-345211-4ivqlsgt 216 86 children child NNS cord-345211-4ivqlsgt 216 87 in in IN cord-345211-4ivqlsgt 216 88 Kenya Kenya NNP cord-345211-4ivqlsgt 216 89 Respiratory respiratory JJ cord-345211-4ivqlsgt 216 90 viruses virus NNS cord-345211-4ivqlsgt 216 91 associated associate VBN cord-345211-4ivqlsgt 216 92 with with IN cord-345211-4ivqlsgt 216 93 community community NN cord-345211-4ivqlsgt 216 94 - - HYPH cord-345211-4ivqlsgt 216 95 acquired acquire VBN cord-345211-4ivqlsgt 216 96 pneumonia pneumonia NN cord-345211-4ivqlsgt 216 97 in in IN cord-345211-4ivqlsgt 216 98 children child NNS cord-345211-4ivqlsgt 216 99 : : : cord-345211-4ivqlsgt 216 100 matched match VBN cord-345211-4ivqlsgt 216 101 case case NN cord-345211-4ivqlsgt 216 102 - - HYPH cord-345211-4ivqlsgt 216 103 control control NN cord-345211-4ivqlsgt 216 104 study study NN cord-345211-4ivqlsgt 217 1 This this DT cord-345211-4ivqlsgt 217 2 recent recent JJ cord-345211-4ivqlsgt 217 3 case case NN cord-345211-4ivqlsgt 217 4 - - HYPH cord-345211-4ivqlsgt 217 5 control control NN cord-345211-4ivqlsgt 217 6 study study NN cord-345211-4ivqlsgt 217 7 highlights highlight VBZ cord-345211-4ivqlsgt 217 8 the the DT cord-345211-4ivqlsgt 217 9 relatively relatively RB cord-345211-4ivqlsgt 217 10 high high JJ cord-345211-4ivqlsgt 217 11 prevalence prevalence NN cord-345211-4ivqlsgt 217 12 of of IN cord-345211-4ivqlsgt 217 13 respiratory respiratory JJ cord-345211-4ivqlsgt 217 14 virus virus NN cord-345211-4ivqlsgt 217 15 detection detection NN cord-345211-4ivqlsgt 217 16 among among IN cord-345211-4ivqlsgt 217 17 community community NN cord-345211-4ivqlsgt 217 18 controls control NNS cord-345211-4ivqlsgt 217 19 and and CC cord-345211-4ivqlsgt 217 20 some some DT cord-345211-4ivqlsgt 217 21 of of IN cord-345211-4ivqlsgt 217 22 the the DT cord-345211-4ivqlsgt 217 23 challenges challenge NNS cord-345211-4ivqlsgt 217 24 with with IN cord-345211-4ivqlsgt 217 25 interpretation interpretation NN cord-345211-4ivqlsgt 217 26 of of IN cord-345211-4ivqlsgt 217 27 positive positive JJ cord-345211-4ivqlsgt 217 28 PCR PCR NNP cord-345211-4ivqlsgt 217 29 results result NNS cord-345211-4ivqlsgt 217 30 in in IN cord-345211-4ivqlsgt 217 31 children child NNS cord-345211-4ivqlsgt 217 32 with with IN cord-345211-4ivqlsgt 217 33 pneumonia pneumonia NN cord-345211-4ivqlsgt 217 34 Epidemiology epidemiology NN cord-345211-4ivqlsgt 217 35 and and CC cord-345211-4ivqlsgt 217 36 clinical clinical JJ cord-345211-4ivqlsgt 217 37 management management NN cord-345211-4ivqlsgt 217 38 of of IN cord-345211-4ivqlsgt 217 39 Legionnaires Legionnaires NNPS cord-345211-4ivqlsgt 217 40 ' ' POS cord-345211-4ivqlsgt 217 41 disease disease NN cord-345211-4ivqlsgt 217 42 Current Current NNP cord-345211-4ivqlsgt 217 43 and and CC cord-345211-4ivqlsgt 217 44 emerging emerge VBG cord-345211-4ivqlsgt 217 45 Legionella Legionella NNP cord-345211-4ivqlsgt 217 46 diagnostics diagnostic NNS cord-345211-4ivqlsgt 217 47 for for IN cord-345211-4ivqlsgt 217 48 laboratory laboratory NN cord-345211-4ivqlsgt 217 49 and and CC cord-345211-4ivqlsgt 217 50 outbreak outbreak NN cord-345211-4ivqlsgt 217 51 investigations investigation NNS cord-345211-4ivqlsgt 218 1 Environmental environmental JJ cord-345211-4ivqlsgt 218 2 legionellosis legionellosis NN cord-345211-4ivqlsgt 218 3 and and CC cord-345211-4ivqlsgt 218 4 oropharyngeal oropharyngeal JJ cord-345211-4ivqlsgt 218 5 colonization colonization NN cord-345211-4ivqlsgt 218 6 by by IN cord-345211-4ivqlsgt 218 7 Legionella Legionella NNP cord-345211-4ivqlsgt 218 8 in in IN cord-345211-4ivqlsgt 218 9 immunosuppressed immunosuppressed JJ cord-345211-4ivqlsgt 218 10 patients patient NNS cord-345211-4ivqlsgt 218 11 Utility Utility NNP cord-345211-4ivqlsgt 218 12 of of IN cord-345211-4ivqlsgt 218 13 real real JJ cord-345211-4ivqlsgt 218 14 - - HYPH cord-345211-4ivqlsgt 218 15 time time NN cord-345211-4ivqlsgt 218 16 PCR PCR NNP cord-345211-4ivqlsgt 218 17 for for IN cord-345211-4ivqlsgt 218 18 diagnosis diagnosis NN cord-345211-4ivqlsgt 218 19 of of IN cord-345211-4ivqlsgt 218 20 legionnaires legionnaire NNS cord-345211-4ivqlsgt 218 21 ' ' POS cord-345211-4ivqlsgt 218 22 disease disease NN cord-345211-4ivqlsgt 218 23 in in IN cord-345211-4ivqlsgt 218 24 routine routine JJ cord-345211-4ivqlsgt 218 25 clinical clinical JJ cord-345211-4ivqlsgt 218 26 practice practice NN cord-345211-4ivqlsgt 218 27 Detection Detection NNP cord-345211-4ivqlsgt 218 28 of of IN cord-345211-4ivqlsgt 218 29 Legionella Legionella NNP cord-345211-4ivqlsgt 218 30 DNA DNA NNP cord-345211-4ivqlsgt 218 31 in in IN cord-345211-4ivqlsgt 218 32 peripheral peripheral JJ cord-345211-4ivqlsgt 218 33 leukocytes leukocyte NNS cord-345211-4ivqlsgt 218 34 , , , cord-345211-4ivqlsgt 218 35 serum serum NN cord-345211-4ivqlsgt 218 36 , , , cord-345211-4ivqlsgt 218 37 and and CC cord-345211-4ivqlsgt 218 38 urine urine NN cord-345211-4ivqlsgt 218 39 from from IN cord-345211-4ivqlsgt 218 40 a a DT cord-345211-4ivqlsgt 218 41 patient patient NN cord-345211-4ivqlsgt 218 42 with with IN cord-345211-4ivqlsgt 218 43 pneumonia pneumonia NN cord-345211-4ivqlsgt 218 44 caused cause VBN cord-345211-4ivqlsgt 218 45 by by IN cord-345211-4ivqlsgt 218 46 Legionella Legionella NNP cord-345211-4ivqlsgt 218 47 dumoffii dumoffii NNP cord-345211-4ivqlsgt 218 48 Impact Impact NNP cord-345211-4ivqlsgt 218 49 of of IN cord-345211-4ivqlsgt 218 50 routine routine JJ cord-345211-4ivqlsgt 218 51 systematic systematic JJ cord-345211-4ivqlsgt 218 52 polymerase polymerase NN cord-345211-4ivqlsgt 218 53 chain chain NN cord-345211-4ivqlsgt 218 54 reaction reaction NN cord-345211-4ivqlsgt 218 55 testing testing NN cord-345211-4ivqlsgt 218 56 on on IN cord-345211-4ivqlsgt 218 57 case case NN cord-345211-4ivqlsgt 218 58 finding find VBG cord-345211-4ivqlsgt 218 59 for for IN cord-345211-4ivqlsgt 218 60 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 218 61 ' ' POS cord-345211-4ivqlsgt 218 62 disease disease NN cord-345211-4ivqlsgt 219 1 : : : cord-345211-4ivqlsgt 219 2 a a DT cord-345211-4ivqlsgt 219 3 pre pre JJ cord-345211-4ivqlsgt 219 4 - - JJ cord-345211-4ivqlsgt 219 5 post post JJ cord-345211-4ivqlsgt 219 6 comparison comparison NN cord-345211-4ivqlsgt 219 7 study study NN cord-345211-4ivqlsgt 220 1 This this DT cord-345211-4ivqlsgt 220 2 study study NN cord-345211-4ivqlsgt 220 3 illustrates illustrate VBZ cord-345211-4ivqlsgt 220 4 a a DT cord-345211-4ivqlsgt 220 5 pragmatic pragmatic JJ cord-345211-4ivqlsgt 220 6 application application NN cord-345211-4ivqlsgt 220 7 of of IN cord-345211-4ivqlsgt 220 8 PCR PCR NNP cord-345211-4ivqlsgt 220 9 for for IN cord-345211-4ivqlsgt 220 10 the the DT cord-345211-4ivqlsgt 220 11 diagnosis diagnosis NN cord-345211-4ivqlsgt 220 12 of of IN cord-345211-4ivqlsgt 220 13 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 220 14 ' ' POS cord-345211-4ivqlsgt 220 15 disease disease NN cord-345211-4ivqlsgt 220 16 Use use NN cord-345211-4ivqlsgt 220 17 of of IN cord-345211-4ivqlsgt 220 18 the the DT cord-345211-4ivqlsgt 220 19 polymerase polymerase NN cord-345211-4ivqlsgt 220 20 chain chain NN cord-345211-4ivqlsgt 220 21 reaction reaction NN cord-345211-4ivqlsgt 220 22 to to TO cord-345211-4ivqlsgt 220 23 detect detect VB cord-345211-4ivqlsgt 220 24 Legionella Legionella NNP cord-345211-4ivqlsgt 220 25 DNA DNA NNP cord-345211-4ivqlsgt 220 26 in in IN cord-345211-4ivqlsgt 220 27 urine urine NN cord-345211-4ivqlsgt 220 28 and and CC cord-345211-4ivqlsgt 220 29 serum serum NN cord-345211-4ivqlsgt 220 30 samples sample NNS cord-345211-4ivqlsgt 220 31 from from IN cord-345211-4ivqlsgt 220 32 patients patient NNS cord-345211-4ivqlsgt 220 33 with with IN cord-345211-4ivqlsgt 220 34 pneumonia pneumonia NN cord-345211-4ivqlsgt 220 35 Diagnosis Diagnosis NNP cord-345211-4ivqlsgt 220 36 of of IN cord-345211-4ivqlsgt 220 37 Legionella Legionella NNP cord-345211-4ivqlsgt 220 38 pneumophila pneumophila NN cord-345211-4ivqlsgt 220 39 , , , cord-345211-4ivqlsgt 220 40 Mycoplasma mycoplasma NN cord-345211-4ivqlsgt 220 41 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 220 42 , , , cord-345211-4ivqlsgt 220 43 or or CC cord-345211-4ivqlsgt 220 44 Chlamydia Chlamydia NNP cord-345211-4ivqlsgt 220 45 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 220 46 lower low JJR cord-345211-4ivqlsgt 220 47 respiratory respiratory JJ cord-345211-4ivqlsgt 220 48 infection infection NN cord-345211-4ivqlsgt 220 49 using use VBG cord-345211-4ivqlsgt 220 50 the the DT cord-345211-4ivqlsgt 220 51 polymerase polymerase NN cord-345211-4ivqlsgt 220 52 chain chain NN cord-345211-4ivqlsgt 220 53 reaction reaction NN cord-345211-4ivqlsgt 220 54 on on IN cord-345211-4ivqlsgt 220 55 a a DT cord-345211-4ivqlsgt 220 56 single single JJ cord-345211-4ivqlsgt 220 57 throat throat NN cord-345211-4ivqlsgt 220 58 swab swab NN cord-345211-4ivqlsgt 220 59 specimen specimen NN cord-345211-4ivqlsgt 220 60 Sensitivity sensitivity NN cord-345211-4ivqlsgt 220 61 of of IN cord-345211-4ivqlsgt 220 62 Legionella Legionella NNP cord-345211-4ivqlsgt 220 63 pneumophila pneumophila NN cord-345211-4ivqlsgt 220 64 DNA dna NN cord-345211-4ivqlsgt 220 65 detection detection NN cord-345211-4ivqlsgt 220 66 in in IN cord-345211-4ivqlsgt 220 67 serum serum NN cord-345211-4ivqlsgt 220 68 samples sample NNS cord-345211-4ivqlsgt 220 69 in in IN cord-345211-4ivqlsgt 220 70 relation relation NN cord-345211-4ivqlsgt 220 71 to to IN cord-345211-4ivqlsgt 220 72 disease disease NN cord-345211-4ivqlsgt 220 73 severity severity NN cord-345211-4ivqlsgt 221 1 Enhanced enhanced JJ cord-345211-4ivqlsgt 221 2 detection detection NN cord-345211-4ivqlsgt 221 3 of of IN cord-345211-4ivqlsgt 221 4 Legionnaires legionnaire NNS cord-345211-4ivqlsgt 221 5 ' ' POS cord-345211-4ivqlsgt 221 6 disease disease NN cord-345211-4ivqlsgt 221 7 by by IN cord-345211-4ivqlsgt 221 8 PCR PCR NNP cord-345211-4ivqlsgt 221 9 testing testing NN cord-345211-4ivqlsgt 221 10 of of IN cord-345211-4ivqlsgt 221 11 induced induce VBN cord-345211-4ivqlsgt 221 12 sputum sputum NN cord-345211-4ivqlsgt 221 13 and and CC cord-345211-4ivqlsgt 221 14 throat throat NN cord-345211-4ivqlsgt 221 15 swabs swab NNS cord-345211-4ivqlsgt 221 16 Contamination contamination NN cord-345211-4ivqlsgt 221 17 of of IN cord-345211-4ivqlsgt 221 18 Qiagen Qiagen NNP cord-345211-4ivqlsgt 221 19 DNA dna NN cord-345211-4ivqlsgt 221 20 extraction extraction NN cord-345211-4ivqlsgt 221 21 kits kit NNS cord-345211-4ivqlsgt 221 22 with with IN cord-345211-4ivqlsgt 221 23 Legionella Legionella NNP cord-345211-4ivqlsgt 221 24 DNA DNA NNP cord-345211-4ivqlsgt 221 25 Acute acute JJ cord-345211-4ivqlsgt 221 26 respiratory respiratory JJ cord-345211-4ivqlsgt 221 27 infection infection NN cord-345211-4ivqlsgt 221 28 due due JJ cord-345211-4ivqlsgt 221 29 to to IN cord-345211-4ivqlsgt 221 30 Mycoplasma mycoplasma NN cord-345211-4ivqlsgt 221 31 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 221 32 : : : cord-345211-4ivqlsgt 221 33 current current JJ cord-345211-4ivqlsgt 221 34 status status NN cord-345211-4ivqlsgt 221 35 of of IN cord-345211-4ivqlsgt 221 36 diagnostic diagnostic JJ cord-345211-4ivqlsgt 221 37 methods method NNS cord-345211-4ivqlsgt 222 1 Molecular molecular JJ cord-345211-4ivqlsgt 222 2 methods method NNS cord-345211-4ivqlsgt 222 3 for for IN cord-345211-4ivqlsgt 222 4 the the DT cord-345211-4ivqlsgt 222 5 detection detection NN cord-345211-4ivqlsgt 222 6 of of IN cord-345211-4ivqlsgt 222 7 Mycoplasma Mycoplasma NNP cord-345211-4ivqlsgt 222 8 and and CC cord-345211-4ivqlsgt 222 9 Ureaplasma Ureaplasma NNP cord-345211-4ivqlsgt 222 10 infections infection NNS cord-345211-4ivqlsgt 222 11 in in IN cord-345211-4ivqlsgt 222 12 humans human NNS cord-345211-4ivqlsgt 222 13 Detection detection NN cord-345211-4ivqlsgt 222 14 and and CC cord-345211-4ivqlsgt 222 15 characterization characterization NN cord-345211-4ivqlsgt 222 16 of of IN cord-345211-4ivqlsgt 222 17 Mycoplasma Mycoplasma NNP cord-345211-4ivqlsgt 222 18 pneumoniae pneumoniae NNS cord-345211-4ivqlsgt 222 19 during during IN cord-345211-4ivqlsgt 222 20 an an DT cord-345211-4ivqlsgt 222 21 outbreak outbreak NN cord-345211-4ivqlsgt 222 22 of of IN cord-345211-4ivqlsgt 222 23 respiratory respiratory JJ cord-345211-4ivqlsgt 222 24 illness illness NN cord-345211-4ivqlsgt 222 25 at at IN cord-345211-4ivqlsgt 222 26 a a DT cord-345211-4ivqlsgt 222 27 university university NN cord-345211-4ivqlsgt 222 28 Polymerase Polymerase NNP cord-345211-4ivqlsgt 222 29 chain chain NN cord-345211-4ivqlsgt 222 30 reaction reaction NN cord-345211-4ivqlsgt 222 31 is be VBZ cord-345211-4ivqlsgt 222 32 superior superior JJ cord-345211-4ivqlsgt 222 33 to to IN cord-345211-4ivqlsgt 222 34 serology serology NN cord-345211-4ivqlsgt 222 35 for for IN cord-345211-4ivqlsgt 222 36 the the DT cord-345211-4ivqlsgt 222 37 diagnosis diagnosis NN cord-345211-4ivqlsgt 222 38 of of IN cord-345211-4ivqlsgt 222 39 acute acute JJ cord-345211-4ivqlsgt 222 40 Mycoplasma Mycoplasma NNP cord-345211-4ivqlsgt 222 41 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 222 42 infection infection NN cord-345211-4ivqlsgt 222 43 and and CC cord-345211-4ivqlsgt 222 44 reveals reveal VBZ cord-345211-4ivqlsgt 222 45 a a DT cord-345211-4ivqlsgt 222 46 high high JJ cord-345211-4ivqlsgt 222 47 rate rate NN cord-345211-4ivqlsgt 222 48 of of IN cord-345211-4ivqlsgt 222 49 persistent persistent JJ cord-345211-4ivqlsgt 222 50 infection infection NN cord-345211-4ivqlsgt 222 51 Standardizing standardize VBG cord-345211-4ivqlsgt 222 52 Chlamydia Chlamydia NNP cord-345211-4ivqlsgt 222 53 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 222 54 assays assay NNS cord-345211-4ivqlsgt 222 55 : : : cord-345211-4ivqlsgt 222 56 recommendations recommendation NNS cord-345211-4ivqlsgt 222 57 from from IN cord-345211-4ivqlsgt 222 58 the the DT cord-345211-4ivqlsgt 222 59 Centers Centers NNPS cord-345211-4ivqlsgt 222 60 for for IN cord-345211-4ivqlsgt 222 61 Diseases Diseases NNPS cord-345211-4ivqlsgt 222 62 Control Control NNP cord-345211-4ivqlsgt 222 63 and and CC cord-345211-4ivqlsgt 222 64 Prevention Prevention NNP cord-345211-4ivqlsgt 222 65 ( ( -LRB- cord-345211-4ivqlsgt 222 66 USA USA NNP cord-345211-4ivqlsgt 222 67 ) ) -RRB- cord-345211-4ivqlsgt 222 68 and and CC cord-345211-4ivqlsgt 222 69 the the DT cord-345211-4ivqlsgt 222 70 Laboratory Laboratory NNP cord-345211-4ivqlsgt 222 71 Centre Centre NNP cord-345211-4ivqlsgt 222 72 for for IN cord-345211-4ivqlsgt 222 73 Disease Disease NNP cord-345211-4ivqlsgt 222 74 Control Control NNP cord-345211-4ivqlsgt 222 75 ( ( -LRB- cord-345211-4ivqlsgt 222 76 Canada Canada NNP cord-345211-4ivqlsgt 222 77 ) ) -RRB- cord-345211-4ivqlsgt 223 1 Recent recent JJ cord-345211-4ivqlsgt 223 2 advances advance NNS cord-345211-4ivqlsgt 223 3 in in IN cord-345211-4ivqlsgt 223 4 the the DT cord-345211-4ivqlsgt 223 5 diagnosis diagnosis NN cord-345211-4ivqlsgt 223 6 of of IN cord-345211-4ivqlsgt 223 7 Pneumocystis Pneumocystis NNP cord-345211-4ivqlsgt 223 8 jirovecii jirovecii NNP cord-345211-4ivqlsgt 223 9 pneumonia pneumonia NN cord-345211-4ivqlsgt 223 10 in in IN cord-345211-4ivqlsgt 223 11 HIV HIV NNP cord-345211-4ivqlsgt 223 12 - - HYPH cord-345211-4ivqlsgt 223 13 infected infect VBN cord-345211-4ivqlsgt 223 14 adults adult NNS cord-345211-4ivqlsgt 223 15 Pneumocystis Pneumocystis NNP cord-345211-4ivqlsgt 223 16 carinii carinii NN cord-345211-4ivqlsgt 223 17 carriage carriage NN cord-345211-4ivqlsgt 223 18 in in IN cord-345211-4ivqlsgt 223 19 immunocompromised immunocompromised JJ cord-345211-4ivqlsgt 223 20 patients patient NNS cord-345211-4ivqlsgt 223 21 with with IN cord-345211-4ivqlsgt 223 22 and and CC cord-345211-4ivqlsgt 223 23 without without IN cord-345211-4ivqlsgt 223 24 human human JJ cord-345211-4ivqlsgt 223 25 immunodeficiency immunodeficiency NN cord-345211-4ivqlsgt 223 26 virus virus NN cord-345211-4ivqlsgt 223 27 infection infection NN cord-345211-4ivqlsgt 223 28 Impact Impact NNP cord-345211-4ivqlsgt 223 29 of of IN cord-345211-4ivqlsgt 223 30 HIV HIV NNP cord-345211-4ivqlsgt 223 31 infection infection NN cord-345211-4ivqlsgt 223 32 status status NN cord-345211-4ivqlsgt 223 33 on on IN cord-345211-4ivqlsgt 223 34 interpretation interpretation NN cord-345211-4ivqlsgt 223 35 of of IN cord-345211-4ivqlsgt 223 36 quantitative quantitative JJ cord-345211-4ivqlsgt 223 37 PCR PCR NNP cord-345211-4ivqlsgt 223 38 for for IN cord-345211-4ivqlsgt 223 39 detection detection NN cord-345211-4ivqlsgt 223 40 of of IN cord-345211-4ivqlsgt 223 41 Pneumocystis Pneumocystis NNP cord-345211-4ivqlsgt 223 42 jirovecii jirovecii NNP cord-345211-4ivqlsgt 223 43 Tuberculosis Tuberculosis NNP cord-345211-4ivqlsgt 223 44 diagnostics diagnostic NNS cord-345211-4ivqlsgt 223 45 in in IN cord-345211-4ivqlsgt 223 46 2015 2015 CD cord-345211-4ivqlsgt 223 47 : : : cord-345211-4ivqlsgt 223 48 landscape landscape NN cord-345211-4ivqlsgt 223 49 , , , cord-345211-4ivqlsgt 223 50 priorities priority NNS cord-345211-4ivqlsgt 223 51 , , , cord-345211-4ivqlsgt 223 52 needs need NNS cord-345211-4ivqlsgt 223 53 , , , cord-345211-4ivqlsgt 223 54 and and CC cord-345211-4ivqlsgt 223 55 prospects prospect NNS cord-345211-4ivqlsgt 223 56 Molecular molecular JJ cord-345211-4ivqlsgt 223 57 diagnostics diagnostic NNS cord-345211-4ivqlsgt 223 58 for for IN cord-345211-4ivqlsgt 223 59 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 223 60 Automated automate VBN cord-345211-4ivqlsgt 223 61 real real JJ cord-345211-4ivqlsgt 223 62 - - HYPH cord-345211-4ivqlsgt 223 63 time time NN cord-345211-4ivqlsgt 223 64 nucleic nucleic JJ cord-345211-4ivqlsgt 223 65 acid acid NN cord-345211-4ivqlsgt 223 66 amplification amplification NN cord-345211-4ivqlsgt 223 67 technology technology NN cord-345211-4ivqlsgt 223 68 for for IN cord-345211-4ivqlsgt 223 69 rapid rapid JJ cord-345211-4ivqlsgt 223 70 and and CC cord-345211-4ivqlsgt 223 71 simultaneous simultaneous JJ cord-345211-4ivqlsgt 223 72 detection detection NN cord-345211-4ivqlsgt 223 73 of of IN cord-345211-4ivqlsgt 223 74 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 223 75 and and CC cord-345211-4ivqlsgt 223 76 rifampicin rifampicin NN cord-345211-4ivqlsgt 223 77 resistance resistance NN cord-345211-4ivqlsgt 223 78 : : : cord-345211-4ivqlsgt 224 1 xpert xpert NNP cord-345211-4ivqlsgt 224 2 MTB MTB NNP cord-345211-4ivqlsgt 224 3 / / SYM cord-345211-4ivqlsgt 224 4 RIF RIF NNP cord-345211-4ivqlsgt 224 5 assay assay NN cord-345211-4ivqlsgt 224 6 for for IN cord-345211-4ivqlsgt 224 7 the the DT cord-345211-4ivqlsgt 224 8 diagnosis diagnosis NN cord-345211-4ivqlsgt 224 9 of of IN cord-345211-4ivqlsgt 224 10 pulmonary pulmonary JJ cord-345211-4ivqlsgt 224 11 and and CC cord-345211-4ivqlsgt 224 12 extrapulmonary extrapulmonary JJ cord-345211-4ivqlsgt 224 13 TB TB NNP cord-345211-4ivqlsgt 224 14 in in IN cord-345211-4ivqlsgt 224 15 adults adult NNS cord-345211-4ivqlsgt 224 16 and and CC cord-345211-4ivqlsgt 224 17 children child NNS cord-345211-4ivqlsgt 224 18 : : : cord-345211-4ivqlsgt 224 19 policy policy NN cord-345211-4ivqlsgt 224 20 update update NN cord-345211-4ivqlsgt 224 21 . . . cord-345211-4ivqlsgt 225 1 Geneva Geneva NNP cord-345211-4ivqlsgt 225 2 : : : cord-345211-4ivqlsgt 226 1 World World NNP cord-345211-4ivqlsgt 226 2 Health Health NNP cord-345211-4ivqlsgt 226 3 Organization Organization NNP cord-345211-4ivqlsgt 226 4 Towards towards IN cord-345211-4ivqlsgt 226 5 improved improved JJ cord-345211-4ivqlsgt 226 6 accuracy accuracy NN cord-345211-4ivqlsgt 226 7 of of IN cord-345211-4ivqlsgt 226 8 Bordetella Bordetella NNP cord-345211-4ivqlsgt 226 9 pertussis pertussis NN cord-345211-4ivqlsgt 226 10 nucleic nucleic VBZ cord-345211-4ivqlsgt 226 11 acid acid NN cord-345211-4ivqlsgt 226 12 amplification amplification NN cord-345211-4ivqlsgt 226 13 tests test NNS cord-345211-4ivqlsgt 226 14 Nucleic nucleic JJ cord-345211-4ivqlsgt 226 15 acid acid NN cord-345211-4ivqlsgt 226 16 amplification amplification NN cord-345211-4ivqlsgt 226 17 tests test NNS cord-345211-4ivqlsgt 226 18 for for IN cord-345211-4ivqlsgt 226 19 diagnosis diagnosis NN cord-345211-4ivqlsgt 226 20 of of IN cord-345211-4ivqlsgt 226 21 Bordetella Bordetella NNP cord-345211-4ivqlsgt 226 22 infections infection NNS cord-345211-4ivqlsgt 226 23 Laboratory Laboratory NNP cord-345211-4ivqlsgt 226 24 diagnosis diagnosis NN cord-345211-4ivqlsgt 226 25 of of IN cord-345211-4ivqlsgt 226 26 pertussis pertussis NN cord-345211-4ivqlsgt 226 27 Bordetella Bordetella NNP cord-345211-4ivqlsgt 226 28 pertussis pertussis NN cord-345211-4ivqlsgt 226 29 in in IN cord-345211-4ivqlsgt 226 30 adult adult NN cord-345211-4ivqlsgt 226 31 pneumonia pneumonia NN cord-345211-4ivqlsgt 226 32 patients patient NNS cord-345211-4ivqlsgt 227 1 Pertussis pertussis NN cord-345211-4ivqlsgt 227 2 : : : cord-345211-4ivqlsgt 227 3 review review NN cord-345211-4ivqlsgt 227 4 of of IN cord-345211-4ivqlsgt 227 5 epidemiology epidemiology NN cord-345211-4ivqlsgt 227 6 , , , cord-345211-4ivqlsgt 227 7 diagnosis diagnosis NN cord-345211-4ivqlsgt 227 8 , , , cord-345211-4ivqlsgt 227 9 management management NN cord-345211-4ivqlsgt 227 10 and and CC cord-345211-4ivqlsgt 227 11 prevention prevention NN cord-345211-4ivqlsgt 227 12 A a DT cord-345211-4ivqlsgt 227 13 boarding board VBG cord-345211-4ivqlsgt 227 14 school school NN cord-345211-4ivqlsgt 227 15 outbreak outbreak NN cord-345211-4ivqlsgt 227 16 of of IN cord-345211-4ivqlsgt 227 17 pertussis pertussis NN cord-345211-4ivqlsgt 227 18 in in IN cord-345211-4ivqlsgt 227 19 adolescents adolescent NNS cord-345211-4ivqlsgt 227 20 : : : cord-345211-4ivqlsgt 227 21 value value NN cord-345211-4ivqlsgt 227 22 of of IN cord-345211-4ivqlsgt 227 23 laboratory laboratory NN cord-345211-4ivqlsgt 227 24 diagnostic diagnostic JJ cord-345211-4ivqlsgt 227 25 methods method NNS cord-345211-4ivqlsgt 227 26 Epidemiology epidemiology NN cord-345211-4ivqlsgt 227 27 and and CC cord-345211-4ivqlsgt 227 28 control control NN cord-345211-4ivqlsgt 227 29 of of IN cord-345211-4ivqlsgt 227 30 pertussis pertussis NN cord-345211-4ivqlsgt 227 31 outbreaks outbreak NNS cord-345211-4ivqlsgt 227 32 in in IN cord-345211-4ivqlsgt 227 33 a a DT cord-345211-4ivqlsgt 227 34 tertiary tertiary JJ cord-345211-4ivqlsgt 227 35 care care NN cord-345211-4ivqlsgt 227 36 center center NN cord-345211-4ivqlsgt 227 37 and and CC cord-345211-4ivqlsgt 227 38 the the DT cord-345211-4ivqlsgt 227 39 resource resource NN cord-345211-4ivqlsgt 227 40 consumption consumption NN cord-345211-4ivqlsgt 227 41 associated associate VBN cord-345211-4ivqlsgt 227 42 with with IN cord-345211-4ivqlsgt 227 43 these these DT cord-345211-4ivqlsgt 227 44 outbreaks outbreak NNS cord-345211-4ivqlsgt 227 45 Laboratory Laboratory NNP cord-345211-4ivqlsgt 227 46 diagnosis diagnosis NN cord-345211-4ivqlsgt 227 47 of of IN cord-345211-4ivqlsgt 227 48 invasive invasive JJ cord-345211-4ivqlsgt 227 49 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 227 50 disease disease NN cord-345211-4ivqlsgt 227 51 Carriage carriage NN cord-345211-4ivqlsgt 227 52 of of IN cord-345211-4ivqlsgt 227 53 Streptococcus Streptococcus NNP cord-345211-4ivqlsgt 227 54 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 227 55 and and CC cord-345211-4ivqlsgt 227 56 other other JJ cord-345211-4ivqlsgt 227 57 respiratory respiratory JJ cord-345211-4ivqlsgt 227 58 bacterial bacterial JJ cord-345211-4ivqlsgt 227 59 pathogens pathogen NNS cord-345211-4ivqlsgt 227 60 in in IN cord-345211-4ivqlsgt 227 61 low low JJ cord-345211-4ivqlsgt 227 62 and and CC cord-345211-4ivqlsgt 227 63 lower low JJR cord-345211-4ivqlsgt 227 64 - - HYPH cord-345211-4ivqlsgt 227 65 middle middle JJ cord-345211-4ivqlsgt 227 66 income income NN cord-345211-4ivqlsgt 227 67 countries country NNS cord-345211-4ivqlsgt 227 68 : : : cord-345211-4ivqlsgt 227 69 a a DT cord-345211-4ivqlsgt 227 70 systematic systematic JJ cord-345211-4ivqlsgt 227 71 review review NN cord-345211-4ivqlsgt 227 72 and and CC cord-345211-4ivqlsgt 227 73 meta meta NNP cord-345211-4ivqlsgt 227 74 - - HYPH cord-345211-4ivqlsgt 227 75 analysis analysis NNP cord-345211-4ivqlsgt 227 76 Evaluation Evaluation NNP cord-345211-4ivqlsgt 227 77 of of IN cord-345211-4ivqlsgt 227 78 a a DT cord-345211-4ivqlsgt 227 79 PCR PCR NNP cord-345211-4ivqlsgt 227 80 assay assay NN cord-345211-4ivqlsgt 227 81 for for IN cord-345211-4ivqlsgt 227 82 detection detection NN cord-345211-4ivqlsgt 227 83 of of IN cord-345211-4ivqlsgt 227 84 Streptococcus streptococcus NN cord-345211-4ivqlsgt 227 85 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 227 86 in in IN cord-345211-4ivqlsgt 227 87 respiratory respiratory JJ cord-345211-4ivqlsgt 227 88 and and CC cord-345211-4ivqlsgt 227 89 nonrespiratory nonrespiratory NN cord-345211-4ivqlsgt 227 90 samples sample NNS cord-345211-4ivqlsgt 227 91 from from IN cord-345211-4ivqlsgt 227 92 adults adult NNS cord-345211-4ivqlsgt 227 93 with with IN cord-345211-4ivqlsgt 227 94 community community NN cord-345211-4ivqlsgt 227 95 - - HYPH cord-345211-4ivqlsgt 227 96 acquired acquire VBN cord-345211-4ivqlsgt 227 97 pneumonia pneumonia NN cord-345211-4ivqlsgt 227 98 Evaluation evaluation NN cord-345211-4ivqlsgt 227 99 and and CC cord-345211-4ivqlsgt 227 100 improvement improvement NN cord-345211-4ivqlsgt 227 101 of of IN cord-345211-4ivqlsgt 227 102 real real JJ cord-345211-4ivqlsgt 227 103 - - HYPH cord-345211-4ivqlsgt 227 104 time time NN cord-345211-4ivqlsgt 227 105 PCR PCR NNP cord-345211-4ivqlsgt 227 106 assays assay NNS cord-345211-4ivqlsgt 227 107 targeting target VBG cord-345211-4ivqlsgt 227 108 lytA lyta VB cord-345211-4ivqlsgt 227 109 , , , cord-345211-4ivqlsgt 227 110 ply ply NN cord-345211-4ivqlsgt 227 111 , , , cord-345211-4ivqlsgt 227 112 and and CC cord-345211-4ivqlsgt 227 113 psaA psaa IN cord-345211-4ivqlsgt 227 114 genes gene NNS cord-345211-4ivqlsgt 227 115 for for IN cord-345211-4ivqlsgt 227 116 detection detection NN cord-345211-4ivqlsgt 227 117 of of IN cord-345211-4ivqlsgt 227 118 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 227 119 DNA DNA NNP cord-345211-4ivqlsgt 227 120 Real real JJ cord-345211-4ivqlsgt 227 121 - - HYPH cord-345211-4ivqlsgt 227 122 time time NN cord-345211-4ivqlsgt 227 123 PCR PCR NNP cord-345211-4ivqlsgt 227 124 is be VBZ cord-345211-4ivqlsgt 227 125 more more RBR cord-345211-4ivqlsgt 227 126 sensitive sensitive JJ cord-345211-4ivqlsgt 227 127 than than IN cord-345211-4ivqlsgt 227 128 multiplex multiplex JJ cord-345211-4ivqlsgt 227 129 PCR pcr NN cord-345211-4ivqlsgt 227 130 for for IN cord-345211-4ivqlsgt 227 131 diagnosis diagnosis NN cord-345211-4ivqlsgt 227 132 and and CC cord-345211-4ivqlsgt 227 133 serotyping serotype VBG cord-345211-4ivqlsgt 227 134 in in IN cord-345211-4ivqlsgt 227 135 children child NNS cord-345211-4ivqlsgt 227 136 with with IN cord-345211-4ivqlsgt 227 137 culture culture NN cord-345211-4ivqlsgt 227 138 negative negative JJ cord-345211-4ivqlsgt 227 139 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 227 140 invasive invasive JJ cord-345211-4ivqlsgt 227 141 disease disease NN cord-345211-4ivqlsgt 227 142 Molecular molecular JJ cord-345211-4ivqlsgt 227 143 detection detection NN cord-345211-4ivqlsgt 227 144 methods method NNS cord-345211-4ivqlsgt 227 145 and and CC cord-345211-4ivqlsgt 227 146 serotyping serotyping NN cord-345211-4ivqlsgt 227 147 performed perform VBN cord-345211-4ivqlsgt 227 148 directly directly RB cord-345211-4ivqlsgt 227 149 on on IN cord-345211-4ivqlsgt 227 150 clinical clinical JJ cord-345211-4ivqlsgt 227 151 samples sample NNS cord-345211-4ivqlsgt 227 152 improve improve VBP cord-345211-4ivqlsgt 227 153 diagnostic diagnostic JJ cord-345211-4ivqlsgt 227 154 sensitivity sensitivity NN cord-345211-4ivqlsgt 227 155 and and CC cord-345211-4ivqlsgt 227 156 reveal reveal VB cord-345211-4ivqlsgt 227 157 increased increase VBN cord-345211-4ivqlsgt 227 158 incidence incidence NN cord-345211-4ivqlsgt 227 159 of of IN cord-345211-4ivqlsgt 227 160 invasive invasive JJ cord-345211-4ivqlsgt 227 161 disease disease NN cord-345211-4ivqlsgt 227 162 by by IN cord-345211-4ivqlsgt 227 163 Streptococcus streptococcus NN cord-345211-4ivqlsgt 227 164 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 227 165 in in IN cord-345211-4ivqlsgt 227 166 Italian italian JJ cord-345211-4ivqlsgt 227 167 children child NNS cord-345211-4ivqlsgt 227 168 Bacteremic Bacteremic NNP cord-345211-4ivqlsgt 227 169 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 227 170 community community NN cord-345211-4ivqlsgt 227 171 - - HYPH cord-345211-4ivqlsgt 227 172 acquired acquire VBN cord-345211-4ivqlsgt 227 173 pneumonia pneumonia NN cord-345211-4ivqlsgt 227 174 in in IN cord-345211-4ivqlsgt 227 175 children child NNS cord-345211-4ivqlsgt 227 176 less less JJR cord-345211-4ivqlsgt 227 177 than than IN cord-345211-4ivqlsgt 227 178 5 5 CD cord-345211-4ivqlsgt 227 179 years year NNS cord-345211-4ivqlsgt 227 180 of of IN cord-345211-4ivqlsgt 227 181 age age NN cord-345211-4ivqlsgt 227 182 in in IN cord-345211-4ivqlsgt 227 183 Italy Italy NNP cord-345211-4ivqlsgt 227 184 Detection Detection NNP cord-345211-4ivqlsgt 227 185 of of IN cord-345211-4ivqlsgt 227 186 Streptococcus Streptococcus NNP cord-345211-4ivqlsgt 227 187 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 227 188 and and CC cord-345211-4ivqlsgt 227 189 identification identification NN cord-345211-4ivqlsgt 227 190 of of IN cord-345211-4ivqlsgt 227 191 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 227 192 serotypes serotype NNS cord-345211-4ivqlsgt 227 193 by by IN cord-345211-4ivqlsgt 227 194 realtime realtime JJ cord-345211-4ivqlsgt 227 195 polymerase polymerase NN cord-345211-4ivqlsgt 227 196 chain chain NN cord-345211-4ivqlsgt 227 197 reaction reaction NN cord-345211-4ivqlsgt 227 198 using use VBG cord-345211-4ivqlsgt 227 199 blood blood NN cord-345211-4ivqlsgt 227 200 samples sample NNS cord-345211-4ivqlsgt 227 201 from from IN cord-345211-4ivqlsgt 227 202 Italian italian JJ cord-345211-4ivqlsgt 227 203 children child NNS cord-345211-4ivqlsgt 227 204 ≤5 ≤5 NN cord-345211-4ivqlsgt 227 205 years year NNS cord-345211-4ivqlsgt 227 206 of of IN cord-345211-4ivqlsgt 227 207 age age NN cord-345211-4ivqlsgt 227 208 with with IN cord-345211-4ivqlsgt 227 209 community community NN cord-345211-4ivqlsgt 227 210 - - HYPH cord-345211-4ivqlsgt 227 211 acquired acquire VBN cord-345211-4ivqlsgt 227 212 pneumonia pneumonia NN cord-345211-4ivqlsgt 227 213 Pneumococcal Pneumococcal NNP cord-345211-4ivqlsgt 227 214 DNA DNA NNP cord-345211-4ivqlsgt 227 215 is be VBZ cord-345211-4ivqlsgt 227 216 not not RB cord-345211-4ivqlsgt 227 217 detectable detectable JJ cord-345211-4ivqlsgt 227 218 in in IN cord-345211-4ivqlsgt 227 219 the the DT cord-345211-4ivqlsgt 227 220 blood blood NN cord-345211-4ivqlsgt 227 221 of of IN cord-345211-4ivqlsgt 227 222 healthy healthy JJ cord-345211-4ivqlsgt 227 223 carrier carrier NN cord-345211-4ivqlsgt 227 224 children child NNS cord-345211-4ivqlsgt 227 225 by by IN cord-345211-4ivqlsgt 227 226 real real JJ cord-345211-4ivqlsgt 227 227 - - HYPH cord-345211-4ivqlsgt 227 228 time time NN cord-345211-4ivqlsgt 227 229 PCR PCR NNP cord-345211-4ivqlsgt 227 230 targeting target VBG cord-345211-4ivqlsgt 227 231 the the DT cord-345211-4ivqlsgt 227 232 lytA lyta JJ cord-345211-4ivqlsgt 227 233 gene gene NN cord-345211-4ivqlsgt 227 234 PCR PCR NNP cord-345211-4ivqlsgt 227 235 using use VBG cord-345211-4ivqlsgt 227 236 blood blood NN cord-345211-4ivqlsgt 227 237 for for IN cord-345211-4ivqlsgt 227 238 diagnosis diagnosis NN cord-345211-4ivqlsgt 227 239 of of IN cord-345211-4ivqlsgt 227 240 invasive invasive JJ cord-345211-4ivqlsgt 227 241 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 227 242 disease disease NN cord-345211-4ivqlsgt 227 243 : : : cord-345211-4ivqlsgt 227 244 systematic systematic JJ cord-345211-4ivqlsgt 227 245 review review NN cord-345211-4ivqlsgt 227 246 and and CC cord-345211-4ivqlsgt 227 247 meta meta NNP cord-345211-4ivqlsgt 227 248 - - HYPH cord-345211-4ivqlsgt 227 249 analysis analysis NN cord-345211-4ivqlsgt 228 1 The the DT cord-345211-4ivqlsgt 228 2 PERCH perch NN cord-345211-4ivqlsgt 228 3 study study NN cord-345211-4ivqlsgt 228 4 group group NN cord-345211-4ivqlsgt 228 5 . . . cord-345211-4ivqlsgt 229 1 Detection detection NN cord-345211-4ivqlsgt 229 2 of of IN cord-345211-4ivqlsgt 229 3 Streptococcus streptococcus NN cord-345211-4ivqlsgt 229 4 pneumoniae pneumoniae NN cord-345211-4ivqlsgt 229 5 by by IN cord-345211-4ivqlsgt 229 6 whole whole JJ cord-345211-4ivqlsgt 229 7 blood blood NN cord-345211-4ivqlsgt 229 8 lytA lyta VBP cord-345211-4ivqlsgt 229 9 PCR PCR NNP cord-345211-4ivqlsgt 229 10 and and CC cord-345211-4ivqlsgt 229 11 association association NN cord-345211-4ivqlsgt 229 12 with with IN cord-345211-4ivqlsgt 229 13 pediatric pediatric JJ cord-345211-4ivqlsgt 229 14 pneumonia pneumonia NN cord-345211-4ivqlsgt 229 15 Detection detection NN cord-345211-4ivqlsgt 229 16 of of IN cord-345211-4ivqlsgt 229 17 bacteria bacteria NNS cord-345211-4ivqlsgt 229 18 and and CC cord-345211-4ivqlsgt 229 19 viruses virus NNS cord-345211-4ivqlsgt 229 20 in in IN cord-345211-4ivqlsgt 229 21 the the DT cord-345211-4ivqlsgt 229 22 pleural pleural JJ cord-345211-4ivqlsgt 229 23 effusion effusion NN cord-345211-4ivqlsgt 229 24 of of IN cord-345211-4ivqlsgt 229 25 children child NNS cord-345211-4ivqlsgt 229 26 and and CC cord-345211-4ivqlsgt 229 27 adults adult NNS cord-345211-4ivqlsgt 229 28 with with IN cord-345211-4ivqlsgt 229 29 community community NN cord-345211-4ivqlsgt 229 30 - - HYPH cord-345211-4ivqlsgt 229 31 acquired acquire VBN cord-345211-4ivqlsgt 229 32 pneumonia pneumonia NN cord-345211-4ivqlsgt 229 33 Pleural Pleural NNP cord-345211-4ivqlsgt 229 34 fluid fluid NN cord-345211-4ivqlsgt 229 35 nucleic nucleic JJ cord-345211-4ivqlsgt 229 36 acid acid NN cord-345211-4ivqlsgt 229 37 testing testing NN cord-345211-4ivqlsgt 229 38 enhances enhance VBZ cord-345211-4ivqlsgt 229 39 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 229 40 surveillance surveillance NN cord-345211-4ivqlsgt 229 41 in in IN cord-345211-4ivqlsgt 229 42 children child NNS cord-345211-4ivqlsgt 229 43 Viral viral JJ cord-345211-4ivqlsgt 229 44 pathogen pathogen NN cord-345211-4ivqlsgt 229 45 discovery discovery NN cord-345211-4ivqlsgt 230 1 The the DT cord-345211-4ivqlsgt 230 2 changing change VBG cord-345211-4ivqlsgt 230 3 face face NN cord-345211-4ivqlsgt 230 4 of of IN cord-345211-4ivqlsgt 230 5 pathogen pathogen NN cord-345211-4ivqlsgt 230 6 discovery discovery NN cord-345211-4ivqlsgt 230 7 and and CC cord-345211-4ivqlsgt 230 8 surveillance surveillance NN cord-345211-4ivqlsgt 231 1 The the DT cord-345211-4ivqlsgt 231 2 use use NN cord-345211-4ivqlsgt 231 3 of of IN cord-345211-4ivqlsgt 231 4 next next JJ cord-345211-4ivqlsgt 231 5 generation generation NN cord-345211-4ivqlsgt 231 6 sequencing sequencing NN cord-345211-4ivqlsgt 231 7 in in IN cord-345211-4ivqlsgt 231 8 the the DT cord-345211-4ivqlsgt 231 9 diagnosis diagnosis NN cord-345211-4ivqlsgt 231 10 and and CC cord-345211-4ivqlsgt 231 11 typing typing NN cord-345211-4ivqlsgt 231 12 of of IN cord-345211-4ivqlsgt 231 13 respiratory respiratory JJ cord-345211-4ivqlsgt 231 14 infections infection NNS cord-345211-4ivqlsgt 231 15 Genetic genetic JJ cord-345211-4ivqlsgt 231 16 testing testing NN cord-345211-4ivqlsgt 231 17 and and CC cord-345211-4ivqlsgt 231 18 FDA FDA NNP cord-345211-4ivqlsgt 231 19 regulation regulation NN cord-345211-4ivqlsgt 231 20 : : : cord-345211-4ivqlsgt 231 21 overregulation overregulation NN cord-345211-4ivqlsgt 231 22 threatens threaten VBZ cord-345211-4ivqlsgt 231 23 the the DT cord-345211-4ivqlsgt 231 24 emergence emergence NN cord-345211-4ivqlsgt 231 25 of of IN cord-345211-4ivqlsgt 231 26 genomic genomic JJ cord-345211-4ivqlsgt 231 27 medicine medicine NN cord-345211-4ivqlsgt 231 28 FDA FDA NNP cord-345211-4ivqlsgt 231 29 regulation regulation NN cord-345211-4ivqlsgt 231 30 of of IN cord-345211-4ivqlsgt 231 31 laboratory laboratory NN cord-345211-4ivqlsgt 231 32 - - HYPH cord-345211-4ivqlsgt 231 33 developed develop VBN cord-345211-4ivqlsgt 231 34 diagnostic diagnostic JJ cord-345211-4ivqlsgt 231 35 tests test NNS cord-345211-4ivqlsgt 231 36 : : : cord-345211-4ivqlsgt 231 37 protect protect VB cord-345211-4ivqlsgt 231 38 the the DT cord-345211-4ivqlsgt 231 39 public public NN cord-345211-4ivqlsgt 231 40 , , , cord-345211-4ivqlsgt 231 41 advance advance VB cord-345211-4ivqlsgt 231 42 the the DT cord-345211-4ivqlsgt 231 43 science science NN cord-345211-4ivqlsgt 232 1 The the DT cord-345211-4ivqlsgt 232 2 lung lung NN cord-345211-4ivqlsgt 232 3 microbiome microbiome NN cord-345211-4ivqlsgt 232 4 : : : cord-345211-4ivqlsgt 232 5 new new JJ cord-345211-4ivqlsgt 232 6 principles principle NNS cord-345211-4ivqlsgt 232 7 for for IN cord-345211-4ivqlsgt 232 8 respiratory respiratory JJ cord-345211-4ivqlsgt 232 9 bacteriology bacteriology NN cord-345211-4ivqlsgt 232 10 in in IN cord-345211-4ivqlsgt 232 11 health health NN cord-345211-4ivqlsgt 232 12 and and CC cord-345211-4ivqlsgt 232 13 disease disease NN cord-345211-4ivqlsgt 233 1 A a DT cord-345211-4ivqlsgt 233 2 recent recent JJ cord-345211-4ivqlsgt 233 3 review review NN cord-345211-4ivqlsgt 233 4 of of IN cord-345211-4ivqlsgt 233 5 recent recent JJ cord-345211-4ivqlsgt 233 6 current current JJ cord-345211-4ivqlsgt 233 7 knowledge knowledge NN cord-345211-4ivqlsgt 233 8 about about IN cord-345211-4ivqlsgt 233 9 the the DT cord-345211-4ivqlsgt 233 10 lung lung NN cord-345211-4ivqlsgt 233 11 microbiome microbiome NN cord-345211-4ivqlsgt 234 1 The the DT cord-345211-4ivqlsgt 234 2 co co NN cord-345211-4ivqlsgt 234 3 - - NN cord-345211-4ivqlsgt 234 4 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 234 5 of of IN cord-345211-4ivqlsgt 234 6 influenza influenza NN cord-345211-4ivqlsgt 234 7 viruses virus NNS cord-345211-4ivqlsgt 234 8 with with IN cord-345211-4ivqlsgt 234 9 bacteria bacteria NNS cord-345211-4ivqlsgt 234 10 in in IN cord-345211-4ivqlsgt 234 11 the the DT cord-345211-4ivqlsgt 234 12 lung lung NN cord-345211-4ivqlsgt 234 13 Viral Viral NNP cord-345211-4ivqlsgt 234 14 bacterial bacterial JJ cord-345211-4ivqlsgt 234 15 co co NN cord-345211-4ivqlsgt 234 16 - - NN cord-345211-4ivqlsgt 234 17 infection infection NN cord-345211-4ivqlsgt 234 18 of of IN cord-345211-4ivqlsgt 234 19 the the DT cord-345211-4ivqlsgt 234 20 respiratory respiratory JJ cord-345211-4ivqlsgt 234 21 tract tract NN cord-345211-4ivqlsgt 234 22 during during IN cord-345211-4ivqlsgt 234 23 early early JJ cord-345211-4ivqlsgt 234 24 childhood childhood NN cord-345211-4ivqlsgt 234 25 Polymicrobial polymicrobial JJ cord-345211-4ivqlsgt 234 26 community community NN cord-345211-4ivqlsgt 234 27 - - HYPH cord-345211-4ivqlsgt 234 28 acquired acquire VBN cord-345211-4ivqlsgt 234 29 pneumonia pneumonia NN cord-345211-4ivqlsgt 234 30 : : : cord-345211-4ivqlsgt 234 31 an an DT cord-345211-4ivqlsgt 234 32 emerging emerge VBG cord-345211-4ivqlsgt 234 33 entity entity NN cord-345211-4ivqlsgt 235 1 The the DT cord-345211-4ivqlsgt 235 2 microbiome microbiome NN cord-345211-4ivqlsgt 235 3 and and CC cord-345211-4ivqlsgt 235 4 critical critical JJ cord-345211-4ivqlsgt 235 5 illness illness NN cord-345211-4ivqlsgt 235 6 Towards towards IN cord-345211-4ivqlsgt 235 7 an an DT cord-345211-4ivqlsgt 235 8 ecology ecology NN cord-345211-4ivqlsgt 235 9 of of IN cord-345211-4ivqlsgt 235 10 the the DT cord-345211-4ivqlsgt 235 11 lung lung NN cord-345211-4ivqlsgt 235 12 : : : cord-345211-4ivqlsgt 235 13 new new JJ cord-345211-4ivqlsgt 235 14 conceptual conceptual JJ cord-345211-4ivqlsgt 235 15 models model NNS cord-345211-4ivqlsgt 235 16 of of IN cord-345211-4ivqlsgt 235 17 pulmonary pulmonary JJ cord-345211-4ivqlsgt 235 18 microbiology microbiology NN cord-345211-4ivqlsgt 235 19 and and CC cord-345211-4ivqlsgt 235 20 pneumonia pneumonia NN cord-345211-4ivqlsgt 235 21 pathogenesis pathogenesis NN cord-345211-4ivqlsgt 235 22 Precision Precision NNP cord-345211-4ivqlsgt 235 23 respiratory respiratory JJ cord-345211-4ivqlsgt 235 24 medicine medicine NN cord-345211-4ivqlsgt 235 25 and and CC cord-345211-4ivqlsgt 235 26 the the DT cord-345211-4ivqlsgt 235 27 microbiome microbiome NN cord-345211-4ivqlsgt 235 28 Analysis Analysis NNP cord-345211-4ivqlsgt 235 29 of of IN cord-345211-4ivqlsgt 235 30 the the DT cord-345211-4ivqlsgt 235 31 upper upper JJ cord-345211-4ivqlsgt 235 32 respiratory respiratory JJ cord-345211-4ivqlsgt 235 33 tract tract NN cord-345211-4ivqlsgt 235 34 microbiotas microbiotas NN cord-345211-4ivqlsgt 235 35 as as IN cord-345211-4ivqlsgt 235 36 the the DT cord-345211-4ivqlsgt 235 37 source source NN cord-345211-4ivqlsgt 235 38 of of IN cord-345211-4ivqlsgt 235 39 the the DT cord-345211-4ivqlsgt 235 40 lung lung NN cord-345211-4ivqlsgt 235 41 and and CC cord-345211-4ivqlsgt 235 42 gastric gastric JJ cord-345211-4ivqlsgt 235 43 microbiotas microbiota NNS cord-345211-4ivqlsgt 235 44 in in IN cord-345211-4ivqlsgt 235 45 healthy healthy JJ cord-345211-4ivqlsgt 235 46 individuals individual NNS cord-345211-4ivqlsgt 236 1 The the DT cord-345211-4ivqlsgt 236 2 microbiome microbiome NN cord-345211-4ivqlsgt 236 3 and and CC cord-345211-4ivqlsgt 236 4 the the DT cord-345211-4ivqlsgt 236 5 respiratory respiratory JJ cord-345211-4ivqlsgt 236 6 tract tract NN cord-345211-4ivqlsgt 236 7 Whole whole JJ cord-345211-4ivqlsgt 236 8 genome genome NN cord-345211-4ivqlsgt 236 9 sequencing sequencing NN cord-345211-4ivqlsgt 236 10 in in IN cord-345211-4ivqlsgt 236 11 clinical clinical JJ cord-345211-4ivqlsgt 236 12 and and CC cord-345211-4ivqlsgt 236 13 public public JJ cord-345211-4ivqlsgt 236 14 health health NN cord-345211-4ivqlsgt 236 15 microbiology microbiology NN cord-345211-4ivqlsgt 236 16 Comprehensive Comprehensive NNP cord-345211-4ivqlsgt 236 17 molecular molecular JJ cord-345211-4ivqlsgt 236 18 testing testing NN cord-345211-4ivqlsgt 236 19 for for IN cord-345211-4ivqlsgt 236 20 respiratory respiratory JJ cord-345211-4ivqlsgt 236 21 pathogens pathogen NNS cord-345211-4ivqlsgt 236 22 in in IN cord-345211-4ivqlsgt 236 23 community community NN cord-345211-4ivqlsgt 236 24 - - HYPH cord-345211-4ivqlsgt 236 25 acquired acquire VBN cord-345211-4ivqlsgt 236 26 pneumonia pneumonia NN cord-345211-4ivqlsgt 236 27 Comparison comparison NN cord-345211-4ivqlsgt 236 28 of of IN cord-345211-4ivqlsgt 236 29 sputum sputum NN cord-345211-4ivqlsgt 236 30 and and CC cord-345211-4ivqlsgt 236 31 nasopharyngeal nasopharyngeal JJ cord-345211-4ivqlsgt 236 32 aspirate aspirate NN cord-345211-4ivqlsgt 236 33 samples sample NNS cord-345211-4ivqlsgt 236 34 and and CC cord-345211-4ivqlsgt 236 35 of of IN cord-345211-4ivqlsgt 236 36 the the DT cord-345211-4ivqlsgt 236 37 PCR PCR NNP cord-345211-4ivqlsgt 236 38 gene gene NN cord-345211-4ivqlsgt 236 39 targets target NNS cord-345211-4ivqlsgt 236 40 lytA lyta VBP cord-345211-4ivqlsgt 236 41 and and CC cord-345211-4ivqlsgt 236 42 Spn9802 Spn9802 NNP cord-345211-4ivqlsgt 236 43 for for IN cord-345211-4ivqlsgt 236 44 quantitative quantitative JJ cord-345211-4ivqlsgt 236 45 PCR PCR NNP cord-345211-4ivqlsgt 236 46 for for IN cord-345211-4ivqlsgt 236 47 rapid rapid JJ cord-345211-4ivqlsgt 236 48 detection detection NN cord-345211-4ivqlsgt 236 49 of of IN cord-345211-4ivqlsgt 236 50 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 236 51 pneumonia pneumonia NN cord-345211-4ivqlsgt 236 52 Genomic Genomic NNP cord-345211-4ivqlsgt 236 53 load load NN cord-345211-4ivqlsgt 236 54 from from IN cord-345211-4ivqlsgt 236 55 sputum sputum NN cord-345211-4ivqlsgt 236 56 samples sample NNS cord-345211-4ivqlsgt 236 57 and and CC cord-345211-4ivqlsgt 236 58 nasopharyngeal nasopharyngeal JJ cord-345211-4ivqlsgt 236 59 swabs swab NNS cord-345211-4ivqlsgt 236 60 for for IN cord-345211-4ivqlsgt 236 61 diagnosis diagnosis NN cord-345211-4ivqlsgt 236 62 of of IN cord-345211-4ivqlsgt 236 63 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 236 64 pneumonia pneumonia NN cord-345211-4ivqlsgt 236 65 in in IN cord-345211-4ivqlsgt 236 66 HIV HIV NNP cord-345211-4ivqlsgt 236 67 - - HYPH cord-345211-4ivqlsgt 236 68 infected infect VBN cord-345211-4ivqlsgt 236 69 adults adult NNS cord-345211-4ivqlsgt 237 1 Use use NN cord-345211-4ivqlsgt 237 2 of of IN cord-345211-4ivqlsgt 237 3 a a DT cord-345211-4ivqlsgt 237 4 rapid rapid JJ cord-345211-4ivqlsgt 237 5 test test NN cord-345211-4ivqlsgt 237 6 of of IN cord-345211-4ivqlsgt 237 7 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 237 8 colonization colonization NN cord-345211-4ivqlsgt 237 9 density density NN cord-345211-4ivqlsgt 237 10 to to TO cord-345211-4ivqlsgt 237 11 diagnose diagnose VB cord-345211-4ivqlsgt 237 12 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 237 13 pneumonia pneumonia NN cord-345211-4ivqlsgt 238 1 • • NNP cord-345211-4ivqlsgt 239 1 The the DT cord-345211-4ivqlsgt 239 2 first first JJ cord-345211-4ivqlsgt 239 3 study study NN cord-345211-4ivqlsgt 239 4 to to TO cord-345211-4ivqlsgt 239 5 demonstrate demonstrate VB cord-345211-4ivqlsgt 239 6 the the DT cord-345211-4ivqlsgt 239 7 potential potential JJ cord-345211-4ivqlsgt 239 8 application application NN cord-345211-4ivqlsgt 239 9 of of IN cord-345211-4ivqlsgt 239 10 nasopharyngeal nasopharyngeal JJ cord-345211-4ivqlsgt 239 11 colonization colonization NN cord-345211-4ivqlsgt 239 12 density density NN cord-345211-4ivqlsgt 239 13 , , , cord-345211-4ivqlsgt 239 14 using use VBG cord-345211-4ivqlsgt 239 15 quantitative quantitative JJ cord-345211-4ivqlsgt 239 16 PCR PCR NNP cord-345211-4ivqlsgt 239 17 , , , cord-345211-4ivqlsgt 239 18 to to TO cord-345211-4ivqlsgt 239 19 diagnose diagnose VB cord-345211-4ivqlsgt 239 20 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 239 21 pneumonia pneumonia NN cord-345211-4ivqlsgt 239 22 in in IN cord-345211-4ivqlsgt 239 23 adults adult NNS cord-345211-4ivqlsgt 240 1 Pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 240 2 colonisation colonisation NN cord-345211-4ivqlsgt 240 3 density density NN cord-345211-4ivqlsgt 240 4 : : : cord-345211-4ivqlsgt 240 5 a a DT cord-345211-4ivqlsgt 240 6 new new JJ cord-345211-4ivqlsgt 240 7 marker marker NN cord-345211-4ivqlsgt 240 8 for for IN cord-345211-4ivqlsgt 240 9 disease disease NN cord-345211-4ivqlsgt 240 10 severity severity NN cord-345211-4ivqlsgt 240 11 in in IN cord-345211-4ivqlsgt 240 12 HIV HIV NNP cord-345211-4ivqlsgt 240 13 - - HYPH cord-345211-4ivqlsgt 240 14 infected infect VBN cord-345211-4ivqlsgt 240 15 adults adult NNS cord-345211-4ivqlsgt 240 16 with with IN cord-345211-4ivqlsgt 240 17 pneumonia pneumonia NNP cord-345211-4ivqlsgt 240 18 Association Association NNP cord-345211-4ivqlsgt 240 19 between between IN cord-345211-4ivqlsgt 240 20 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 240 21 load load NN cord-345211-4ivqlsgt 240 22 and and CC cord-345211-4ivqlsgt 240 23 disease disease NN cord-345211-4ivqlsgt 240 24 severity severity NN cord-345211-4ivqlsgt 240 25 in in IN cord-345211-4ivqlsgt 240 26 adults adult NNS cord-345211-4ivqlsgt 240 27 with with IN cord-345211-4ivqlsgt 240 28 pneumonia pneumonia NN cord-345211-4ivqlsgt 240 29 Severity severity NN cord-345211-4ivqlsgt 240 30 of of IN cord-345211-4ivqlsgt 240 31 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 240 32 pneumonia pneumonia NN cord-345211-4ivqlsgt 240 33 associated associate VBN cord-345211-4ivqlsgt 240 34 with with IN cord-345211-4ivqlsgt 240 35 genomic genomic JJ cord-345211-4ivqlsgt 240 36 bacterial bacterial JJ cord-345211-4ivqlsgt 240 37 load load NN cord-345211-4ivqlsgt 240 38 Classical Classical NNP cord-345211-4ivqlsgt 240 39 and and CC cord-345211-4ivqlsgt 240 40 latent latent JJ cord-345211-4ivqlsgt 240 41 class class NN cord-345211-4ivqlsgt 240 42 analysis analysis NN cord-345211-4ivqlsgt 240 43 evaluation evaluation NN cord-345211-4ivqlsgt 240 44 of of IN cord-345211-4ivqlsgt 240 45 sputum sputum NN cord-345211-4ivqlsgt 240 46 polymerase polymerase NN cord-345211-4ivqlsgt 240 47 chain chain NN cord-345211-4ivqlsgt 240 48 reaction reaction NN cord-345211-4ivqlsgt 240 49 and and CC cord-345211-4ivqlsgt 240 50 urine urine NN cord-345211-4ivqlsgt 240 51 antigen antigen NN cord-345211-4ivqlsgt 240 52 testing testing NN cord-345211-4ivqlsgt 240 53 for for IN cord-345211-4ivqlsgt 240 54 diagnosis diagnosis NN cord-345211-4ivqlsgt 240 55 of of IN cord-345211-4ivqlsgt 240 56 pneumococcal pneumococcal JJ cord-345211-4ivqlsgt 240 57 pneumonia pneumonia NN cord-345211-4ivqlsgt 240 58 in in IN cord-345211-4ivqlsgt 240 59 adults adult NNS cord-345211-4ivqlsgt 240 60 Estimating estimate VBG cord-345211-4ivqlsgt 240 61 the the DT cord-345211-4ivqlsgt 240 62 proportion proportion NN cord-345211-4ivqlsgt 240 63 of of IN cord-345211-4ivqlsgt 240 64 pneumonia pneumonia NN cord-345211-4ivqlsgt 240 65 attributable attributable JJ cord-345211-4ivqlsgt 240 66 to to IN cord-345211-4ivqlsgt 240 67 pneumococcus pneumococcus NN cord-345211-4ivqlsgt 240 68 in in IN cord-345211-4ivqlsgt 240 69 Kenyan kenyan JJ cord-345211-4ivqlsgt 240 70 adults adult NNS cord-345211-4ivqlsgt 240 71 : : : cord-345211-4ivqlsgt 241 1 latent latent JJ cord-345211-4ivqlsgt 241 2 class class NN cord-345211-4ivqlsgt 241 3 analysis analysis NN cord-345211-4ivqlsgt 241 4 Comparison comparison NN cord-345211-4ivqlsgt 241 5 of of IN cord-345211-4ivqlsgt 241 6 TB TB NNP cord-345211-4ivqlsgt 241 7 - - HYPH cord-345211-4ivqlsgt 241 8 LAMP LAMP NNP cord-345211-4ivqlsgt 241 9 , , , cord-345211-4ivqlsgt 241 10 GeneXpert GeneXpert NNP cord-345211-4ivqlsgt 241 11 MTB MTB NNP cord-345211-4ivqlsgt 241 12 / / SYM cord-345211-4ivqlsgt 241 13 RIF RIF NNP cord-345211-4ivqlsgt 241 14 and and CC cord-345211-4ivqlsgt 241 15 culture culture NN cord-345211-4ivqlsgt 241 16 for for IN cord-345211-4ivqlsgt 241 17 diagnosis diagnosis NN cord-345211-4ivqlsgt 241 18 of of IN cord-345211-4ivqlsgt 241 19 pulmonary pulmonary JJ cord-345211-4ivqlsgt 241 20 tuberculosis tuberculosis NN cord-345211-4ivqlsgt 241 21 in in IN cord-345211-4ivqlsgt 241 22 The the DT cord-345211-4ivqlsgt 241 23 Gambia Gambia NNP cord-345211-4ivqlsgt 241 24 A a DT cord-345211-4ivqlsgt 241 25 Bayesian bayesian JJ cord-345211-4ivqlsgt 241 26 framework framework NN cord-345211-4ivqlsgt 241 27 for for IN cord-345211-4ivqlsgt 241 28 estimating estimate VBG cord-345211-4ivqlsgt 241 29 the the DT cord-345211-4ivqlsgt 241 30 incremental incremental JJ cord-345211-4ivqlsgt 241 31 value value NN cord-345211-4ivqlsgt 241 32 of of IN cord-345211-4ivqlsgt 241 33 a a DT cord-345211-4ivqlsgt 241 34 diagnostic diagnostic JJ cord-345211-4ivqlsgt 241 35 test test NN cord-345211-4ivqlsgt 241 36 in in IN cord-345211-4ivqlsgt 241 37 the the DT cord-345211-4ivqlsgt 241 38 absence absence NN cord-345211-4ivqlsgt 241 39 of of IN cord-345211-4ivqlsgt 241 40 a a DT cord-345211-4ivqlsgt 241 41 gold gold NN cord-345211-4ivqlsgt 241 42 standard standard NN cord-345211-4ivqlsgt 242 1 The the DT cord-345211-4ivqlsgt 242 2 pneumonia pneumonia NN cord-345211-4ivqlsgt 242 3 etiology etiology NN cord-345211-4ivqlsgt 242 4 research research NN cord-345211-4ivqlsgt 242 5 for for IN cord-345211-4ivqlsgt 242 6 child child NN cord-345211-4ivqlsgt 242 7 health health NN cord-345211-4ivqlsgt 242 8 project project NN cord-345211-4ivqlsgt 242 9 : : : cord-345211-4ivqlsgt 243 1 A a DT cord-345211-4ivqlsgt 243 2 21st 21st JJ cord-345211-4ivqlsgt 243 3 century century NN cord-345211-4ivqlsgt 243 4 childhood childhood NN cord-345211-4ivqlsgt 243 5 pneumonia pneumonia NN cord-345211-4ivqlsgt 243 6 etiology etiology NN cord-345211-4ivqlsgt 243 7 study study NN cord-345211-4ivqlsgt 244 1 The the DT cord-345211-4ivqlsgt 244 2 pneumonia pneumonia NN cord-345211-4ivqlsgt 244 3 etiology etiology NN cord-345211-4ivqlsgt 244 4 research research NN cord-345211-4ivqlsgt 244 5 for for IN cord-345211-4ivqlsgt 244 6 child child NN cord-345211-4ivqlsgt 244 7 health health NN cord-345211-4ivqlsgt 244 8 core core NN cord-345211-4ivqlsgt 244 9 team team NN cord-345211-4ivqlsgt 244 10 . . . cord-345211-4ivqlsgt 245 1 Partially partially RB cord-345211-4ivqlsgt 245 2 latent latent JJ cord-345211-4ivqlsgt 245 3 class class NN cord-345211-4ivqlsgt 245 4 models model NNS cord-345211-4ivqlsgt 245 5 for for IN cord-345211-4ivqlsgt 245 6 case case NN cord-345211-4ivqlsgt 245 7 - - HYPH cord-345211-4ivqlsgt 245 8 control control NN cord-345211-4ivqlsgt 245 9 studies study NNS cord-345211-4ivqlsgt 245 10 of of IN cord-345211-4ivqlsgt 245 11 childhood childhood NN cord-345211-4ivqlsgt 245 12 pneumonia pneumonia NN cord-345211-4ivqlsgt 245 13 aetiology aetiology NN