cord-001989-6gi3o5mu	2016	METHODS: For this methodological review, we searched MEDLINE via PubMed, from January 1, 2013 to December 31, 2013 for meta-analyses including at least one non-randomized study evaluating therapeutic interventions. CONCLUSIONS: Some key methodological components of the systematic review process—search for grey literature, description of the type of NRSI included, assessment of risk of confounding bias and reporting of whether crude or adjusted estimates were combined—are not adequately carried out or reported in meta-analyses including NRSI. Therefore, an increasing number of systematic reviews and meta-analyses are including data from non-randomized studies to assess therapeutic interventions. To illustrate: a metaanalysis that investigated the association of the use of statins and risk of cancer would was considered a therapeutic evaluation if the authors planned to include RCTs. Individual patient data meta-analyses were also excluded, as were non-randomized studies that conducted a meta-analysis of the literature as secondary analysis.
cord-013477-dzm4xi21	2020	The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. Results showed that 100 mg/kg curcumin significantly reduced blood glucose and insulin levels, increased hepatic glycogen content, and improved oxidative stress by reducing thiobarbituric acid reactive substance (TBARS) and increasing glutathione (GSH) levels, superoxide dismutase (SOD), and catalase (CAT) activities in the liver of diabetic pregnant mice at gestational day 20. The authors evaluated the possible mechanisms responsible for these effects and found that curcumin-induced apoptosis was associated with the modulation of pro-and anti-apoptotic molecules (i.e., increased Bax and reduced Bcl-2 expression), ROS generation, and caspase-3 activation [66] .
cord-014687-0am4l5ms	2012	This presentation will focus on recent developments that have lead to a better understanding of the embryopathogenesis for fibropolycystic liver diseases (including choledochal cysts and Caroli disease), histopathological findings that have led to new classification systems for of pediatric vascular anomalies, technological advances and contrast agents in magnetic resonance imaging that are useful to characterize and limit the differential diagnosis of hepatic masses. Disclosure: Dr. Annapragada has indicated that he is a stock holder and consultant for Marval Biosciences Inc. Paper #: PA-067 Cardiovascular Image Quality Using a Nanoparticle CT Contrast Agent: Preliminary Studies in a Pig Model Rajesh Krishnamurthy, Radiology, Texas Children''s Hospital, rxkrishn@texaschildrens.org; Ketan Ghaghada, Prakash Masand, Abhay Divekar, Eric Hoffman, Ananth Annapragada Purpose or Case Report: Image quality in a separate study using a long circulating, liposomal-based nanoscale blood pool iodinated contrast agent (NCTX) suggests clinical utility in pediatrics, potentially reducing difficulties in contrast-CT of children with congenital heart disease (CHD) including the size of intravenous cannula, need for accurate timing, inability to simultaneously opacify multiple targets of interest (requiring repeated contrast administration and/or repeated imaging).
cord-020901-aew8xr6n	2020	TransRev learns vector representations for At training time, a function''s parameters are learned to compute the review embedding from the word token embeddings such that the embedding of the user translated by the review embedding is similar to the product embedding. Methods that fall into this category such as [31, 32] learn latent representations of users and items from the text content so as to perform well at rating prediction. Similar to sentiment analysis methods, TransRev trains a regression model that predicts the review rating from the review text. We compare to the following methods: a SVD matrix factorization; HFT, which has not often been benchmarked in previous works; and DeepCoNN [38] , which learns user and item representations from reviews via convolutional neural networks. Representation learning of users and items for review rating prediction using attention-based convolutional neural network
cord-020905-gw8i6tkn	2020	To model such customer expectations and capture important information from a review text, we propose a novel neural network which leverages review sentiment and product information. In order to address the above issues, we propose a novel neural network architecture to introduce sentiment and product information when identifying helpful content from a review text. In the cold start scenario, our proposed model demonstrates an AUC improvement of 5.4% and 1.5% on Amazon and Yelp data sets, respectively, when compared to the state of the art model. From Table 5 , we see that adding a sentiment attention layer (HSA) to the base model (HBiLSTM) results in an average improvement in the AUC score of 2.0% and 2.6%, respectively on the Amazon and Yelp data sets. In this paper, we describe our analysis of review helpfulness prediction and propose a novel neural network model with attention modules to incorporate sentiment and product information.
cord-032077-6wtdq0ia	2020	The search of literature was performed till May 10, 2020, till when there were no published studies with ten or more patients describing the pediatric multisystem inflammatory syndrome (PMIS). We do not agree with the author''s suggestion of including PMIS in the screening strategy for COVID-19 in children. As of now, PMIS is a rare and poorly understood presentation of COVID-19 in children [2] . Living systematic review (LSR) is an emerging approach in which the review is updated frequently (classically at monthly intervals) and usually published online-only. COVID-19 children: Clinical and epidemiological implications. Coronavirus disease 2019 (COVID-19) in children -What we know so far and what we do not Clinical features and outcome of SARS-CoV-2 infection in children: A systematic review and meta-analysis Clinical features and outcome of SARS-CoV-2 infection in children: A systematic review and meta-analysis Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19
cord-269377-ylgyvxtd	2020	Stroke in the setting of viral vasculopathy has been described with other viruses, such as varicella zoster virus (VZV) or 1 ; more recently, it has also been associated with other coronavirus, namely, Middle East respiratory syndrome coronavirus, during the outbreak in Saudi Arabia in 2012. The imaging presentation of multiple lesions involving deep and subcortical white matter, as well as deep gray nuclei, with marked restricted diffusion of some, has been described in the setting of VZV vasculopathy. Primary angiitis of the central nervous system was also considered, but the absence of obvious large vessel irregularities, normal CSF cellular count, and concomitant SARS-CoV-2 infection led us consider a COVID-19-related vasculopathy as the most probable diagnosis, potentially induced by misdirected immune mediated-vasoconstriction of medium-/ small-sized arteries; we believe this represents a new imaging presentation of a SARS-CoV-2-related complication.
cord-271363-nsjn05q0	2020	• Given the urgent need for credible answers to high-priority questions about the health and social impacts of COVID-19, many systematic reviewers seek to contribute their skills and expertise; • Rather than embarking on unnecessary, duplicate reviews, we encourage the evidence synthesis community to prioritise purposeful replication of systematic reviews of evidence relevant to COVID-19. We believe that while original reviews are essential, decision making during the pandemic would benefit also from the purposeful replication of some systematic reviews of evidence relevant to COVID-19. Along with minimising production of unnecessary, duplicate reviews, we encourage the evidence synthesis community to prioritise purposeful replication of some systematic reviews of evidence relevant to COVID-19. Based on registration data in PROSPERO, there are many systematic reviewers keen to contribute to the COVID-19 research effort, who could band together to work on purposeful replications that evaluate the impact of abbreviated methods on review findings, rather than proceeding with a redundant review.
cord-273119-jfy0iviy	2020	In UK radiotherapy departments, radiation therapist (review radiographer)-led clinics moved to telephone-based clinics to reduce the time spent by patients in a hospital environment. The pandemic has forced patients to slow down and really focus on themselves which has led to picking up physical and mental health changes earlier. As a radiation therapist (therapeutic radiographer) and member of the radiotherapy review team, I see patients throughout their radiotherapy treatments to address their physical and emotional side effects. Those of us in the radiotherapy review team have changed to telephone appointments to minimize time spent by patients in a hospital environment. Telephone reviews aren''t a new process within healthcare (4); oncology teams use telephone triage when patients report treatment related side effects. In my opinion, radiotherapy reviews are more in depth than triage calls as they cover all aspects of a patient''s care and side effects to help them live with and beyond cancer.
cord-283340-ksyd5l56	2020	OBJECTIVE: The aim of this study was to analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews. Specifically, we conducted an umbrella review to evaluate the findings of systematic reviews and/or metaanalyses that investigated the relationship of dyslipidemia and severity of COVID-19 infection and to assess the evidence regarding potential limitations and the consistency of findings. The following criteria were applied to identify the articles to be included in the present umbrella review: (1) systematic reviews and/or meta-analyses; (2) studies involving adults who tested positive for COVID-19; and (3) studies reporting the association between dyslipidemia and COVID-19 infection. Two authors (G.J.C. and H.M.K.) independently extracted the outcomes on the relationship of dyslipidemia or non-dyslipidemia and lipid profile with COVID-19 infection severity from the identified systematic reviews and meta-analyses.
cord-290421-9v841ose	2020	The current paper presents a synthesis of review literature discussing the application of behaviour change theories within an infectious disease and emergency response context, with a view to informing infectious disease modelling, research and public health practice. Papers were included if they presented a review of theoretical models as applied to understanding preventative health behaviours in the context of emergency preparedness and response, and/or infectious disease outbreaks. Although this is based on key outcomes/ conclusions and not an exhaustive list of all successful theories reported within/ across reviews, the commonly applied behaviour change theories do seem to be identified as relevant for understanding and explaining human behaviour within an infectious disease and emergency response context. Based on these identified theories and our synthesis of review outcomes, and in conjunction with a recent review by Weston and colleagues [26] , we make recommendations to assist researchers, intervention designers, and mathematical modellers to incorporate psychological behaviour change theories within infectious disease and emergency response contexts.
cord-299269-ylyhlyzw	2020	We comprehensively searched the following databases: Medline, EMBASE, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang Data and CBM (SinoMed) from their inception to 31 March 2020, and other sources to identify systematic reviews and meta-analyses related to supportive treatments for patient with respiratory diseases including COVID-19, SARS, MERS and influenza. We included systematic reviews and meta-analyses related to supportive treatment for patient with respiratory diseases including COVID-19, SARS, MERS and influenza published in English and Chinese without other restrictions. 13.20064360 doi: medRxiv preprint reviews and meta-analyses that focused on the proportion of medical staff, monitoring of vital signs, respiratory and circulatory support, and psychological intervention. We also considered systematic reviews and meta-analyses with related indirect evidence if no sufficient literature on COVID-19, SARS, MERS and influenza was found. We comprehensively searched systematic reviews and meta-analyses on SARS, MERS, COVID-19 and influenza and evaluated the quality of methodology and evidence.
cord-309350-7qen8z3y	2020	SUMMARY: The present umbrella review suggests that EVC, and likely HNBC, despite clearly causing an increase in overall cardiovascular risk, may represent a temporary lesser evil than TCC in a risk-reduction or risk-modification strategy, aiming for eventual abstinence from all tobacco or nicotine products. Kennedy and colleagues reviewed several experimental and clinical studies on the cardiovascular safety of EVC, highlighting that they may cause oxidative stress, cardiomyocyte dysfunction and mutagenesis, vascular inflammation, endothelial dysfunction, vasospasm, complement deposition, platelet aggregation, adhesion, and activation, with hypertension, tachycardia, arterial stiffening, atherosclerosis and thrombotic risk, albeit less intensely than TCC [25] . Our umbrella review, poignantly synthesizing the evidence accrued so far from in vitro, in animal, in human volunteers, healthy subjects, and patients on the cardiovascular risk associated with EVC use, either acute or chronic, shows that data are expanding progressively, but several conclusions can already be made on the 31] .
cord-313056-wuo7zerg	2020	A search was performed in the Traditional, Complementary and Integrative Medicine Virtual Health Library and PubMed, using the MeSH and DeCS terms for respiratory viral diseases associated with epidemics, COVID-19 symptoms, relevant mental health topics, pharmacological and non-pharmacological interventions related to TCIM. RESULTS: For the map, 126 systematic reviews and controlled clinical studies were characterized, distributed in a matrix with 57 interventions (18 phytotherapy, 9 mind-body therapies, 10 traditional chinese medicine, 3 homeopathic and anthroposophic dynamized medicines and 17 supplements), and 67 outcomes (14 immunological response, 23 mental health, 25 complementary clinical management of the infection and 5 other). A search strategy was developed, using the MeSH and DeCS terms for respiratory viral diseases associated with epidemics, COVID-19 symptoms, relevant mental health topics, pharmacological interventions related to TCIM (medicinal plants/ phytotherapy, herbal medicine, Chinese and Ayurvedic herbology, drugs related to homeopathy and anthroposophic medicine, probiotics, nutritional supplements, among others), as well as non-pharmacological TCIM interventions (yoga, taichi, mindfulness, meditation, qigong, tapping, body practices, among others).
cord-321827-e7zc44ca	2017	This paper reports on this overview, which aimed to identify high quality evidence of the determinants and consequences of turnover in nurses working in the field of adult health care services and bring that evidence together into one place to highlight where strong enough evidence to support managerial decisions exists and where gaps in the evidence may indicate the need for further research, particularly when considered in the context of the broader management literature regarding turnover. The empirical evidence shows that stress and issues concerning leadership consistently exert both direct and indirect effects on job satisfaction and intent to leave There are a number of published articles characterized by loosely defined terms The main reasons for reviews being in the moderate rather than strong evidence category were the lack of publication of an a priori protocol, varying levels of details about the search strategy performed, the failure to have two reviewers check the selection and data extraction, not providing a list of both included and excluded primary studies (with the exception of Toh et al.
cord-327652-tn29r8lj	2020	In response to urgent needs for updated evidence for decision-making on various aspects related to coronavirus disease (COVID-19), the Norwegian Institute of Public Health established a rapid review team. While keeping up with scientific developments is challenging also under normal circumstances, the combination of uncertainties in dealing with a novel virus and a huge outpour of research papers dealing with COVID-19, many of them not peer-reviewed, made it particularly challenging to provide evidence-informed guidance, either to the public, health services or policymakers. In addition, systematic reviews on COVID-19-related topics were likely to become rapidly outdated, given the large number of new study reports published daily. Being a national public health institute with responsibilities for infectious diseases prevention and response, as well as having the role as the national centre for evidence-based healthcare, meant that the competence and tools to develop the rapid reviews were available within the organisation.
cord-328902-c91mthxv	2020	Cases requiring special procedures (brachytherapy, radiosurgery, total body irradiation, intra-operative radiation therapy) are currently being revised by groups with experience in those techniques prior to treatment delivery and only controversial treatment indications (i.e., salvage treatment with brachytherapy for irradiated patients) or cases in which boost with HDR-BT is going to be performed after EBRT (i.e., breast cancer, cervical cancer) go through our peer-review conferences before starting treatment. Based on our group peer-review process, we prospectively recollected some data on cases presented at our institutional conference to quantify the rate of plan changes, time and resources needed for this process. Cases were then analyzed to determine the rate of major change, minor change and plan rejection after presentation as well as the type of change (dose/fractionation, contouring, technique or combination) and also median time per session.
cord-333806-e3v67hpx	2020	To better understand the landscape of early childhood environmental education (ECEE) pedagogical practices and expected outcomes, we undertook a systematic review of empirical studies of ECEE programs. In the articles we 351 reviewed, the most frequently reported outcomes were related to the category of Environmental During the initial coding process, we found that researchers described evidence of more 371 than 150 pedagogical practices associated with effective ECEE programs among the 66 studies. 379 The most frequently studied ECEE programs involved children in the four-and five-year-453 old age ranges participating in ongoing, educator-facilitated programs that included time in 454 nature-rich settings and occurred in a formal setting, such as a school, daycare, or early 455 childhood center.
cord-334480-aosmo568	2020	title: Efficacy of remdesivir versus placebo for the treatment of COVID-19: A protocol for systematic review and meta-analysis of randomized controlled trials Here, we aim to conduct a systematic review and meta-analysis of randomized controlled trials to compare the effectiveness of remdesivir and placebo in patients with COVID-19. We will include randomized controlled trials that assessed the effectiveness of remdesivir versus placebo for patients confirmed with COVID-19. Ethics and dissemination: This study does not require ethical approval, because no participants data will be involved in this systematic review and meta-analysis. Keywords: 2019 novel coronavirus, 2019-nCoV, Coronavirus diseases 2019, COVID-19, SARS-cov-2, Remdesivir, Randomized Controlled Trials. This systematic review and meta-analysis will be derived from only randomized controlled trials which will reduce between study heterogeneity. https://doi.org/10.1101/2020.04.09.20059196 doi: medRxiv preprint meta-analysis of RCTs to compare the effectiveness of remdesivir and placebo in patients with COVID-19.
cord-344902-bittqpyo	2020	title: A systematic review of the physical activity levels of acutely ill older adults in Hospital At Home settings: an under-researched field PURPOSE: The purpose of this review was to identify, evaluate and synthesise existing evidence reporting the physical activity levels of acutely ill older patients in a ''Hospital At Home'' setting and compare this to patients with similar characteristics treated in a traditional hospital inpatient setting. CONCLUSION: There is a lack of published research on the physical activity levels of acutely-ill older adults in Hospital at Home settings. The aim of this review was to identify, evaluate and synthesise the evidence on the physical activity levels of acutely ill older patients undergoing treatment in an HaH vs inpatient setting. This review has provided an indication of the baseline activity levels of inpatients suitable for a Hospital at Home service, however primary objective research is needed in this treatment setting.
cord-347446-yw0nk7fo	2020	In our review, the analysis of 23 studies show evidence that high temperature and high humidity reduce the COVID-19 transmission. The aim of the review was, therefore, to summarize all available data on the impact of environmental factors on the survival of all coronaviruses including emerging SARS-CoV and MERS CoV. This systematic review was limited to studies focusing to environmental factors'' impact on COVID-19. All included studies assessed the role of various environmental factors on transmission rates of the COVID-19. Detailed characteristics of the studies included, like author, title and year of publication, country and continent of the study, method of assessing the impact of the environmental factors and the outcome variable are described in Table 1 . . https://doi.org/10.1101/2020.05.10.20069732 doi: medRxiv preprint Figure 2 Temperature associated with the assessing methods the country of epidemics All rights reserved. . https://doi.org/10.1101 Figure 2 Environmental factors associated with the assessing methods the country of epidemics All rights reserved.
cord-349161-4899cq99	2008	For diagnostic accuracy studies, measures of test performance (sensitivity, specificity, predictive values, likelihood ratios or diagnostic odds ratio) are plotted on the horizontal axis. ROC plots can be used to present the results of diagnostic systematic reviews, but differ from those used in primary studies as each point typically represents a separate study or data set within a study (individual studies may contribute more than one point). A summary ROC (SROC) curve can be estimated using one of several methods [12] [13] [14] [15] and quantifies test accuracy and the association between sensitivity and specificity based on differences between studies. A number of graphical displays aim to put results of diagnostic test evaluations into clinical context, based either on primary studies or systematic reviews. The inclusion of graphical displays, such as SROC plots or forest plots, in systematic reviews of test accuracy studies allows a visual assessment of heterogeneity between studies by showing the results from each individual study included in the review.