id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285339-pwy1ry4n	Tarigan, Ronald	Role of pattern recognition receptors and interferon-beta in protecting bat cell lines from encephalomyocarditis virus and Japanese encephalitis virus infection	2020-06-18		.txt	text/plain	3174	155	55	Here, kidney epithelial cell lines derived from four bat species (Pteropus dasymallus, Rousettus leschenaultii, Rhinolophus ferrumequinum, and Miniopterus fuliginosus) and two non-bat species (Homo sapiens and Mesocricetus auratus) were infected with EMCV and JEV. fuliginosus with a higher expression level of pattern recognition receptors (PRRs) (TLR3, RIG-I, and MDA5) and interferon-beta (IFN-β) than that in the non-bat cell lines and a bat cell line derived from P. The knockdown of TLR3, RIG-I, and MDA5 in Rhinolophus bat cell line using antisense RNA oligonucleotide led to decrease IFN-β expression and increased viral replication. EMCV and JEV infection resulted in a higher expression level of PRRs in bat cell lines with a lower viral replication level (DEMKT1, BKT1, and YUBFKT1) (Fig. 2B, C, and 2D ).	./cache/cord-285339-pwy1ry4n.txt	./txt/cord-285339-pwy1ry4n.txt