id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305737-bnzd7b25	Rehwinkel, Jan	Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence	2013-05-23		.txt	text/plain	4133	246	55	Targeting the viral Achilles' heel: recognition of 5 0 -triphosphate RNA in innate anti-viral defence Jan Rehwinkel 1 and Caetano Reis e Sousa 2 Some RNA virus genomes bear 5 0 -triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5 0 -triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA virus infection while IFITs sequester viral RNAs to exert an antiviral effect. Recent work shows that the IFN system targets 5PPP RNAs during both phases: both RIG-I, a virus sensor that induces IFN expression, and IFITs, effector molecules that execute anti-viral activities, can specifically recognize 5PPP RNAs. As such, 5PPP RNAs appear to be Achilles' heel of many RNA viruses in their interaction with the innate immune system (Figure 3a ).	./cache/cord-305737-bnzd7b25.txt	./txt/cord-305737-bnzd7b25.txt