id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307914-lgprrwee	Bartok, Eva	Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids	2020-07-14		.txt	text/plain	17726	1100	51	Indeed, the functionalization of CRISPR/Cas systems as a tool for genomic editing have revealed important differences in human and murine NA sensing, including distinct cell subset expression patterns of NA-sensing Toll-Like Receptors (TLRs) or species differences in the structural requirements for the detection of cyclic dinucleotide cGAMP by STING. As a long dsRNA with a 5 0 diphosphate terminus, polyI:C is known to activate the sensing receptors TLR3, MDA5, and RIG-I (Alexopoulou et al., 2001; Gitlin et al., 2006; Kato et al., 2008; Yoneyama et al., 2005) , accessory proteins such including LGP2 and members of the DDX and DHX families (reviewed in Oshiumi et al., 2016) as well as the restriction factors PKR and the OAS family (Farrell et al., 1978; Hovanessian et al., 1977; Zilberstein et al., 1978) .	./cache/cord-307914-lgprrwee.txt	./txt/cord-307914-lgprrwee.txt