id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321607-3r736dnk	Ezelle, Heather J.	The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response	2016-01-08		.txt	text/plain	11694	588	42	The active nuclease then cleaves ssRNAs, both cellular and viral, leading to downregulation of their expression and the generation of small RNAs capable of activating retinoic acid-inducible gene-I (RIG-I)-like receptors or the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome. Although cleavage of RNA virus genomes appeared as the most direct mechanism of action, other important pathways have become evident, such as the regulation of host gene expression, stimulation of IFNβ production, activation of the NACHT, LRR, and PYD-containing protein-3 (NLRP3) inflammasome, and maintenance of the cell's structural barrier to infection [27, 55, 83, 84] . These small RNAs are capable of stimulating RIG-I and MDA5 (melanoma differentiation associated gene-5) to activate mitochondrial antiviral signaling protein (MAVS) and induce the subsequent translocation of interferon regulatory factor 3 (IRF3) to the nucleus to drive transcription of IFNβ.	./cache/cord-321607-3r736dnk.txt	./txt/cord-321607-3r736dnk.txt