id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328252-dk54w8z9	Kikkert, Marjolein	Innate Immune Evasion by Human Respiratory RNA Viruses	2019-10-14		.txt	text/plain	11552	550	43	Whether PA-X also degrades viral dsRNA species to prevent recognition by cytosolic RNA sensors is not entirely clear, but mutant viruses in which this PA-X protein was expressed in significantly lower amounts elicited higher levels of innate immune response; for example, IFN-beta production was much higher in these infections [71] . This indeed suggests that PA-X, besides having a role in the degradation of cellular mRNAs, may also degrade viral RNA to prevent recognition by innate immune sensors and activation of innate immune responses, similar to what was shown for the CoVs. To my knowledge, an endoribonuclease has not been identified in the RSV genome, so this virus may use alternative innate immune evasion strategies, as discussed elsewhere in this review. [91] suggested that RSV specifically targets mRNA encoding surfactant protein A, an innate immune factor with an important role in the epithelial tissue of the lung, which directly binds to virus particles to cause their destruction by host defense mechanisms.	./cache/cord-328252-dk54w8z9.txt	./txt/cord-328252-dk54w8z9.txt