id author title date pages extension mime words sentences flesch summary cache txt cord-346916-jj4l9ydl Girardi, Erika Roadblocks and fast tracks: How RNA binding proteins affect the viral RNA journey in the cell 2020-08-23 .txt text/plain 13119 728 45 Moreover, despite the molecular mimicry set by RNA viruses to resemble cellular mRNAs and escape host recognition, the viral nucleic acid still needs to embark on a long journey through a hostile cell environment and must overcome the obstacles put in place by the host antiviral system in order to be translated and replicated. Another example, is the zinc-finger antiviral protein (ZAP), which binds vRNAs containing a ZAP response element (ZRE) and induces RNA degradation via interaction of its N-terminal domain with host decay machinery mediated [75] (Fig. 1 ). In fact, IRES elements present in the genome of different families of RNA viruses lack overall conserved features [146, 147] .The classification of viral IRESs in four types stems from their structural organization, their respective dependence on sets of translation initiation factors, and whether they use scanning or instead directly recruit ribosomes to the start codon [148] (Fig. 2) . ./cache/cord-346916-jj4l9ydl.txt ./txt/cord-346916-jj4l9ydl.txt