id	sid	tid	token	lemma	pos
cord-007689-0vpp3xdl	1	1	key	key	NN
cord-007689-0vpp3xdl	1	2	:	:	:
cord-007689-0vpp3xdl	2	1	cord-007689	cord-007689	NN
cord-007689-0vpp3xdl	2	2	-	-	HYPH
cord-007689-0vpp3xdl	2	3	0vpp3xdl	0vpp3xdl	CD
cord-007689-0vpp3xdl	2	4	authors	author	NNS
cord-007689-0vpp3xdl	2	5	:	:	:
cord-007689-0vpp3xdl	2	6	Schlee	Schlee	NNP
cord-007689-0vpp3xdl	2	7	,	,	,
cord-007689-0vpp3xdl	2	8	M.	M.	NNP
cord-007689-0vpp3xdl	2	9	;	;	:
cord-007689-0vpp3xdl	2	10	Barchet	Barchet	NNP
cord-007689-0vpp3xdl	2	11	,	,	,
cord-007689-0vpp3xdl	2	12	W.	W.	NNP
cord-007689-0vpp3xdl	2	13	;	;	:
cord-007689-0vpp3xdl	2	14	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	2	15	,	,	,
cord-007689-0vpp3xdl	2	16	V.	V.	NNP
cord-007689-0vpp3xdl	2	17	;	;	:
cord-007689-0vpp3xdl	2	18	Hartmann	Hartmann	NNP
cord-007689-0vpp3xdl	2	19	,	,	,
cord-007689-0vpp3xdl	3	1	G.	G.	NNP
cord-007689-0vpp3xdl	3	2	title	title	NN
cord-007689-0vpp3xdl	3	3	:	:	:
cord-007689-0vpp3xdl	4	1	Beyond	beyond	IN
cord-007689-0vpp3xdl	4	2	Double	double	JJ
cord-007689-0vpp3xdl	4	3	-	-	HYPH
cord-007689-0vpp3xdl	4	4	Stranded	Stranded	NNP
cord-007689-0vpp3xdl	4	5	RNA	RNA	NNP
cord-007689-0vpp3xdl	4	6	-	-	HYPH
cord-007689-0vpp3xdl	4	7	Type	type	NN
cord-007689-0vpp3xdl	5	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	5	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	5	3	Induction	Induction	NNP
cord-007689-0vpp3xdl	5	4	by	by	IN
cord-007689-0vpp3xdl	5	5	3pRNA	3prna	CD
cord-007689-0vpp3xdl	5	6	and	and	CC
cord-007689-0vpp3xdl	5	7	Other	other	JJ
cord-007689-0vpp3xdl	5	8	Viral	Viral	NNP
cord-007689-0vpp3xdl	5	9	Nucleic	nucleic	JJ
cord-007689-0vpp3xdl	5	10	Acids	acid	NNS
cord-007689-0vpp3xdl	5	11	date	date	NN
cord-007689-0vpp3xdl	5	12	:	:	:
cord-007689-0vpp3xdl	6	1	2007	2007	CD
cord-007689-0vpp3xdl	6	2	journal	journal	NNP
cord-007689-0vpp3xdl	6	3	:	:	:
cord-007689-0vpp3xdl	7	1	Interferon	interferon	NN
cord-007689-0vpp3xdl	7	2	:	:	:
cord-007689-0vpp3xdl	8	1	The	the	DT
cord-007689-0vpp3xdl	8	2	50th	50th	JJ
cord-007689-0vpp3xdl	8	3	Anniversary	anniversary	NN
cord-007689-0vpp3xdl	8	4	DOI	doi	NN
cord-007689-0vpp3xdl	8	5	:	:	:
cord-007689-0vpp3xdl	8	6	10.1007/978	10.1007/978	CD
cord-007689-0vpp3xdl	8	7	-	-	HYPH
cord-007689-0vpp3xdl	8	8	3	3	CD
cord-007689-0vpp3xdl	8	9	-	-	HYPH
cord-007689-0vpp3xdl	8	10	540	540	CD
cord-007689-0vpp3xdl	8	11	-	-	HYPH
cord-007689-0vpp3xdl	8	12	71329	71329	CD
cord-007689-0vpp3xdl	8	13	-	-	HYPH
cord-007689-0vpp3xdl	8	14	6_11	6_11	CD
cord-007689-0vpp3xdl	8	15	sha	sha	NNP
cord-007689-0vpp3xdl	8	16	:	:	:
cord-007689-0vpp3xdl	9	1	e59a051e4ff6f3a30b91203cdb0a1503d0050d21	e59a051e4ff6f3a30b91203cdb0a1503d0050d21	NNP
cord-007689-0vpp3xdl	9	2	doc_id	doc_id	CD
cord-007689-0vpp3xdl	9	3	:	:	:
cord-007689-0vpp3xdl	9	4	7689	7689	CD
cord-007689-0vpp3xdl	9	5	cord_uid	cord_uid	NNS
cord-007689-0vpp3xdl	9	6	:	:	:
cord-007689-0vpp3xdl	10	1	0vpp3xdl	0vpp3xdl	NFP
cord-007689-0vpp3xdl	11	1	Production	production	NN
cord-007689-0vpp3xdl	11	2	of	of	IN
cord-007689-0vpp3xdl	11	3	type	type	NN
cord-007689-0vpp3xdl	12	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	12	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	12	3	is	be	VBZ
cord-007689-0vpp3xdl	12	4	the	the	DT
cord-007689-0vpp3xdl	12	5	key	key	JJ
cord-007689-0vpp3xdl	12	6	response	response	NN
cord-007689-0vpp3xdl	12	7	to	to	IN
cord-007689-0vpp3xdl	12	8	viral	viral	JJ
cord-007689-0vpp3xdl	12	9	infection	infection	NN
cord-007689-0vpp3xdl	12	10	.	.	.
cord-007689-0vpp3xdl	13	1	Since	since	IN
cord-007689-0vpp3xdl	13	2	the	the	DT
cord-007689-0vpp3xdl	13	3	discovery	discovery	NN
cord-007689-0vpp3xdl	13	4	of	of	IN
cord-007689-0vpp3xdl	13	5	type	type	NN
cord-007689-0vpp3xdl	13	6	I	-PRON-	PRP
cord-007689-0vpp3xdl	13	7	IFNs	ifns	VBP
cord-007689-0vpp3xdl	13	8	in	in	IN
cord-007689-0vpp3xdl	13	9	1957	1957	CD
cord-007689-0vpp3xdl	13	10	,	,	,
cord-007689-0vpp3xdl	13	11	long	long	RB
cord-007689-0vpp3xdl	13	12	double	double	RB
cord-007689-0vpp3xdl	13	13	-	-	HYPH
cord-007689-0vpp3xdl	13	14	stranded	strand	VBN
cord-007689-0vpp3xdl	13	15	RNA	RNA	NNP
cord-007689-0vpp3xdl	13	16	formed	form	VBN
cord-007689-0vpp3xdl	13	17	during	during	IN
cord-007689-0vpp3xdl	13	18	replication	replication	NN
cord-007689-0vpp3xdl	13	19	of	of	IN
cord-007689-0vpp3xdl	13	20	many	many	JJ
cord-007689-0vpp3xdl	13	21	viruses	virus	NNS
cord-007689-0vpp3xdl	13	22	was	be	VBD
cord-007689-0vpp3xdl	13	23	thought	think	VBN
cord-007689-0vpp3xdl	13	24	to	to	TO
cord-007689-0vpp3xdl	13	25	be	be	VB
cord-007689-0vpp3xdl	13	26	responsible	responsible	JJ
cord-007689-0vpp3xdl	13	27	for	for	IN
cord-007689-0vpp3xdl	13	28	type	type	NN
cord-007689-0vpp3xdl	14	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	14	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	14	3	induction	induction	NN
cord-007689-0vpp3xdl	14	4	,	,	,
cord-007689-0vpp3xdl	14	5	and	and	CC
cord-007689-0vpp3xdl	14	6	for	for	IN
cord-007689-0vpp3xdl	14	7	decades	decade	NNS
cord-007689-0vpp3xdl	14	8	double	double	RB
cord-007689-0vpp3xdl	14	9	-	-	HYPH
cord-007689-0vpp3xdl	14	10	stranded	strand	VBN
cord-007689-0vpp3xdl	14	11	RNA	RNA	NNP
cord-007689-0vpp3xdl	14	12	-	-	HYPH
cord-007689-0vpp3xdl	14	13	activated	activate	VBN
cord-007689-0vpp3xdl	14	14	protein	protein	NN
cord-007689-0vpp3xdl	14	15	kinase	kinase	NN
cord-007689-0vpp3xdl	14	16	(	(	-LRB-
cord-007689-0vpp3xdl	14	17	PKR	PKR	NNP
cord-007689-0vpp3xdl	14	18	)	)	-RRB-
cord-007689-0vpp3xdl	14	19	was	be	VBD
cord-007689-0vpp3xdl	14	20	thought	think	VBN
cord-007689-0vpp3xdl	14	21	to	to	TO
cord-007689-0vpp3xdl	14	22	be	be	VB
cord-007689-0vpp3xdl	14	23	the	the	DT
cord-007689-0vpp3xdl	14	24	receptor	receptor	NN
cord-007689-0vpp3xdl	14	25	.	.	.
cord-007689-0vpp3xdl	15	1	Recently	recently	RB
cord-007689-0vpp3xdl	15	2	,	,	,
cord-007689-0vpp3xdl	15	3	this	this	DT
cord-007689-0vpp3xdl	15	4	picture	picture	NN
cord-007689-0vpp3xdl	15	5	has	have	VBZ
cord-007689-0vpp3xdl	15	6	dramatically	dramatically	RB
cord-007689-0vpp3xdl	15	7	changed	change	VBN
cord-007689-0vpp3xdl	15	8	.	.	.
cord-007689-0vpp3xdl	16	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	16	2	now	now	RB
cord-007689-0vpp3xdl	16	3	became	become	VBD
cord-007689-0vpp3xdl	16	4	evident	evident	JJ
cord-007689-0vpp3xdl	16	5	that	that	IN
cord-007689-0vpp3xdl	16	6	not	not	RB
cord-007689-0vpp3xdl	16	7	PKR	PKR	NNP
cord-007689-0vpp3xdl	16	8	but	but	CC
cord-007689-0vpp3xdl	16	9	two	two	CD
cord-007689-0vpp3xdl	16	10	members	member	NNS
cord-007689-0vpp3xdl	16	11	of	of	IN
cord-007689-0vpp3xdl	16	12	the	the	DT
cord-007689-0vpp3xdl	16	13	Toll	Toll	NNP
cord-007689-0vpp3xdl	16	14	-	-	HYPH
cord-007689-0vpp3xdl	16	15	like	like	JJ
cord-007689-0vpp3xdl	16	16	receptor	receptor	NN
cord-007689-0vpp3xdl	16	17	(	(	-LRB-
cord-007689-0vpp3xdl	16	18	TLR	TLR	NNP
cord-007689-0vpp3xdl	16	19	)	)	-RRB-
cord-007689-0vpp3xdl	16	20	family	family	NN
cord-007689-0vpp3xdl	16	21	,	,	,
cord-007689-0vpp3xdl	16	22	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	16	23	and	and	CC
cord-007689-0vpp3xdl	16	24	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	16	25	,	,	,
cord-007689-0vpp3xdl	16	26	and	and	CC
cord-007689-0vpp3xdl	16	27	two	two	CD
cord-007689-0vpp3xdl	16	28	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	16	29	helicases	helicase	NNS
cord-007689-0vpp3xdl	16	30	,	,	,
cord-007689-0vpp3xdl	16	31	RIG	rig	NN
cord-007689-0vpp3xdl	16	32	-	-	:
cord-007689-0vpp3xdl	16	33	I	I	NNP
cord-007689-0vpp3xdl	16	34	and	and	CC
cord-007689-0vpp3xdl	16	35	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	16	36	,	,	,
cord-007689-0vpp3xdl	16	37	are	be	VBP
cord-007689-0vpp3xdl	16	38	responsible	responsible	JJ
cord-007689-0vpp3xdl	16	39	for	for	IN
cord-007689-0vpp3xdl	16	40	the	the	DT
cord-007689-0vpp3xdl	16	41	majority	majority	NN
cord-007689-0vpp3xdl	16	42	of	of	IN
cord-007689-0vpp3xdl	16	43	type	type	NN
cord-007689-0vpp3xdl	17	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	17	2	IFNs	ifns	VBP
cord-007689-0vpp3xdl	17	3	induced	induce	VBN
cord-007689-0vpp3xdl	17	4	upon	upon	IN
cord-007689-0vpp3xdl	17	5	recognition	recognition	NN
cord-007689-0vpp3xdl	17	6	of	of	IN
cord-007689-0vpp3xdl	17	7	viral	viral	JJ
cord-007689-0vpp3xdl	17	8	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	17	9	acids	acid	NNS
cord-007689-0vpp3xdl	17	10	.	.	.
cord-007689-0vpp3xdl	18	1	In	in	IN
cord-007689-0vpp3xdl	18	2	this	this	DT
cord-007689-0vpp3xdl	18	3	review	review	NN
cord-007689-0vpp3xdl	18	4	,	,	,
cord-007689-0vpp3xdl	18	5	we	-PRON-	PRP
cord-007689-0vpp3xdl	18	6	focus	focus	VBP
cord-007689-0vpp3xdl	18	7	on	on	IN
cord-007689-0vpp3xdl	18	8	the	the	DT
cord-007689-0vpp3xdl	18	9	molecular	molecular	JJ
cord-007689-0vpp3xdl	18	10	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	18	11	by	by	IN
cord-007689-0vpp3xdl	18	12	which	which	WDT
cord-007689-0vpp3xdl	18	13	those	those	DT
cord-007689-0vpp3xdl	18	14	innate	innate	VBP
cord-007689-0vpp3xdl	18	15	immune	immune	JJ
cord-007689-0vpp3xdl	18	16	receptors	receptor	NNS
cord-007689-0vpp3xdl	18	17	detect	detect	VBP
cord-007689-0vpp3xdl	18	18	viral	viral	JJ
cord-007689-0vpp3xdl	18	19	infection	infection	NN
cord-007689-0vpp3xdl	18	20	.	.	.
cord-007689-0vpp3xdl	19	1	Based	base	VBN
cord-007689-0vpp3xdl	19	2	on	on	IN
cord-007689-0vpp3xdl	19	3	the	the	DT
cord-007689-0vpp3xdl	19	4	recent	recent	JJ
cord-007689-0vpp3xdl	19	5	progress	progress	NN
cord-007689-0vpp3xdl	19	6	in	in	IN
cord-007689-0vpp3xdl	19	7	the	the	DT
cord-007689-0vpp3xdl	19	8	field	field	NN
cord-007689-0vpp3xdl	19	9	,	,	,
cord-007689-0vpp3xdl	19	10	we	-PRON-	PRP
cord-007689-0vpp3xdl	19	11	now	now	RB
cord-007689-0vpp3xdl	19	12	know	know	VBP
cord-007689-0vpp3xdl	19	13	that	that	IN
cord-007689-0vpp3xdl	19	14	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	19	15	,	,	,
cord-007689-0vpp3xdl	19	16	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	19	17	,	,	,
cord-007689-0vpp3xdl	19	18	and	and	CC
cord-007689-0vpp3xdl	19	19	RIG	rig	NN
cord-007689-0vpp3xdl	19	20	-	-	:
cord-007689-0vpp3xdl	19	21	I	-PRON-	PRP
cord-007689-0vpp3xdl	19	22	do	do	VBP
cord-007689-0vpp3xdl	19	23	not	not	RB
cord-007689-0vpp3xdl	19	24	require	require	VB
cord-007689-0vpp3xdl	19	25	long	long	JJ
cord-007689-0vpp3xdl	19	26	double	double	RB
cord-007689-0vpp3xdl	19	27	-	-	HYPH
cord-007689-0vpp3xdl	19	28	stranded	strand	VBN
cord-007689-0vpp3xdl	19	29	RNA	RNA	NNP
cord-007689-0vpp3xdl	19	30	for	for	IN
cord-007689-0vpp3xdl	19	31	type	type	NN
cord-007689-0vpp3xdl	19	32	I	-PRON-	PRP
cord-007689-0vpp3xdl	19	33	IFN	IFN	NNP
cord-007689-0vpp3xdl	19	34	induction	induction	NN
cord-007689-0vpp3xdl	19	35	.	.	.
cord-007689-0vpp3xdl	20	1	Type	type	NN
cord-007689-0vpp3xdl	20	2	I	-PRON-	PRP
cord-007689-0vpp3xdl	20	3	IFNs	ifns	NN
cord-007689-0vpp3xdl	20	4	(	(	-LRB-
cord-007689-0vpp3xdl	20	5	IFN	IFN	NNP
cord-007689-0vpp3xdl	20	6	-	-	HYPH
cord-007689-0vpp3xdl	20	7	α	α	NNP
cord-007689-0vpp3xdl	20	8	isoforms	isoform	NNS
cord-007689-0vpp3xdl	20	9	and	and	CC
cord-007689-0vpp3xdl	20	10	IFN	IFN	NNP
cord-007689-0vpp3xdl	20	11	-	-	HYPH
cord-007689-0vpp3xdl	20	12	β	β	NNP
cord-007689-0vpp3xdl	20	13	)	)	-RRB-
cord-007689-0vpp3xdl	20	14	are	be	VBP
cord-007689-0vpp3xdl	20	15	regarded	regard	VBN
cord-007689-0vpp3xdl	20	16	as	as	IN
cord-007689-0vpp3xdl	20	17	the	the	DT
cord-007689-0vpp3xdl	20	18	dominant	dominant	JJ
cord-007689-0vpp3xdl	20	19	mediators	mediator	NNS
cord-007689-0vpp3xdl	20	20	of	of	IN
cord-007689-0vpp3xdl	20	21	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	20	22	defense	defense	NN
cord-007689-0vpp3xdl	20	23	in	in	IN
cord-007689-0vpp3xdl	20	24	vertebrates	vertebrate	NNS
cord-007689-0vpp3xdl	20	25	.	.	.
cord-007689-0vpp3xdl	21	1	Since	since	IN
cord-007689-0vpp3xdl	21	2	their	-PRON-	PRP$
cord-007689-0vpp3xdl	21	3	initial	initial	JJ
cord-007689-0vpp3xdl	21	4	discovery	discovery	NN
cord-007689-0vpp3xdl	21	5	half	half	NN
cord-007689-0vpp3xdl	21	6	a	a	DT
cord-007689-0vpp3xdl	21	7	century	century	NN
cord-007689-0vpp3xdl	21	8	ago	ago	RB
cord-007689-0vpp3xdl	21	9	as	as	IN
cord-007689-0vpp3xdl	21	10	acid	acid	NN
cord-007689-0vpp3xdl	21	11	-	-	HYPH
cord-007689-0vpp3xdl	21	12	stable	stable	JJ
cord-007689-0vpp3xdl	21	13	,	,	,
cord-007689-0vpp3xdl	21	14	soluble	soluble	JJ
cord-007689-0vpp3xdl	21	15	factors	factor	NNS
cord-007689-0vpp3xdl	21	16	"	"	``
cord-007689-0vpp3xdl	21	17	interfering	interfere	VBG
cord-007689-0vpp3xdl	21	18	"	"	''
cord-007689-0vpp3xdl	21	19	with	with	IN
cord-007689-0vpp3xdl	21	20	viral	viral	JJ
cord-007689-0vpp3xdl	21	21	proliferation	proliferation	NN
cord-007689-0vpp3xdl	21	22	in	in	IN
cord-007689-0vpp3xdl	21	23	cultured	cultured	JJ
cord-007689-0vpp3xdl	21	24	cells	cell	NNS
cord-007689-0vpp3xdl	21	25	(	(	-LRB-
cord-007689-0vpp3xdl	21	26	Isaacs	Isaacs	NNP
cord-007689-0vpp3xdl	21	27	and	and	CC
cord-007689-0vpp3xdl	21	28	Lindenmann	Lindenmann	NNP
cord-007689-0vpp3xdl	21	29	1957	1957	CD
cord-007689-0vpp3xdl	21	30	;	;	:
cord-007689-0vpp3xdl	21	31	Nagano	Nagano	NNP
cord-007689-0vpp3xdl	21	32	and	and	CC
cord-007689-0vpp3xdl	21	33	Kojima	Kojima	NNP
cord-007689-0vpp3xdl	21	34	1958	1958	CD
cord-007689-0vpp3xdl	21	35	)	)	-RRB-
cord-007689-0vpp3xdl	21	36	,	,	,
cord-007689-0vpp3xdl	21	37	intense	intense	JJ
cord-007689-0vpp3xdl	21	38	research	research	NN
cord-007689-0vpp3xdl	21	39	has	have	VBZ
cord-007689-0vpp3xdl	21	40	focused	focus	VBN
cord-007689-0vpp3xdl	21	41	on	on	IN
cord-007689-0vpp3xdl	21	42	type	type	NN
cord-007689-0vpp3xdl	22	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	22	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	22	3	receptor	receptor	NN
cord-007689-0vpp3xdl	22	4	signaling	signal	VBG
cord-007689-0vpp3xdl	22	5	and	and	CC
cord-007689-0vpp3xdl	22	6	the	the	DT
cord-007689-0vpp3xdl	22	7	plethora	plethora	NN
cord-007689-0vpp3xdl	22	8	of	of	IN
cord-007689-0vpp3xdl	22	9	type	type	NN
cord-007689-0vpp3xdl	23	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	23	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	23	3	-	-	HYPH
cord-007689-0vpp3xdl	23	4	mediated	mediate	VBN
cord-007689-0vpp3xdl	23	5	effects	effect	NNS
cord-007689-0vpp3xdl	23	6	(	(	-LRB-
cord-007689-0vpp3xdl	23	7	Theofilopoulos	Theofilopoulos	NNP
cord-007689-0vpp3xdl	23	8	et	et	NNP
cord-007689-0vpp3xdl	23	9	al	al	NNP
cord-007689-0vpp3xdl	23	10	.	.	NNP
cord-007689-0vpp3xdl	23	11	2005	2005	CD
cord-007689-0vpp3xdl	23	12	)	)	-RRB-
cord-007689-0vpp3xdl	23	13	.	.	.
cord-007689-0vpp3xdl	24	1	For	for	IN
cord-007689-0vpp3xdl	24	2	the	the	DT
cord-007689-0vpp3xdl	24	3	host	host	NN
cord-007689-0vpp3xdl	24	4	,	,	,
cord-007689-0vpp3xdl	24	5	an	an	DT
cord-007689-0vpp3xdl	24	6	intact	intact	JJ
cord-007689-0vpp3xdl	24	7	type	type	NN
cord-007689-0vpp3xdl	25	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	25	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	25	3	response	response	NN
cord-007689-0vpp3xdl	25	4	is	be	VBZ
cord-007689-0vpp3xdl	25	5	critical	critical	JJ
cord-007689-0vpp3xdl	25	6	for	for	IN
cord-007689-0vpp3xdl	25	7	the	the	DT
cord-007689-0vpp3xdl	25	8	survival	survival	NN
cord-007689-0vpp3xdl	25	9	of	of	IN
cord-007689-0vpp3xdl	25	10	many	many	JJ
cord-007689-0vpp3xdl	25	11	viral	viral	JJ
cord-007689-0vpp3xdl	25	12	infections	infection	NNS
cord-007689-0vpp3xdl	25	13	(	(	-LRB-
cord-007689-0vpp3xdl	25	14	Gresser	Gresser	NNP
cord-007689-0vpp3xdl	25	15	et	et	NNP
cord-007689-0vpp3xdl	25	16	al	al	NNP
cord-007689-0vpp3xdl	25	17	.	.	.
cord-007689-0vpp3xdl	25	18	1976	1976	CD
cord-007689-0vpp3xdl	25	19	;	;	:
cord-007689-0vpp3xdl	25	20	Muller	Muller	NNP
cord-007689-0vpp3xdl	25	21	et	et	NNP
cord-007689-0vpp3xdl	25	22	al	al	NNP
cord-007689-0vpp3xdl	25	23	.	.	.
cord-007689-0vpp3xdl	25	24	1994	1994	CD
cord-007689-0vpp3xdl	25	25	)	)	-RRB-
cord-007689-0vpp3xdl	25	26	.	.	.
cord-007689-0vpp3xdl	26	1	Sensing	sensing	NN
cord-007689-0vpp3xdl	26	2	of	of	IN
cord-007689-0vpp3xdl	26	3	viral	viral	JJ
cord-007689-0vpp3xdl	26	4	replication	replication	NN
cord-007689-0vpp3xdl	26	5	has	have	VBZ
cord-007689-0vpp3xdl	26	6	been	be	VBN
cord-007689-0vpp3xdl	26	7	proposed	propose	VBN
cord-007689-0vpp3xdl	26	8	to	to	TO
cord-007689-0vpp3xdl	26	9	be	be	VB
cord-007689-0vpp3xdl	26	10	responsible	responsible	JJ
cord-007689-0vpp3xdl	26	11	for	for	IN
cord-007689-0vpp3xdl	26	12	triggering	trigger	VBG
cord-007689-0vpp3xdl	26	13	the	the	DT
cord-007689-0vpp3xdl	26	14	production	production	NN
cord-007689-0vpp3xdl	26	15	of	of	IN
cord-007689-0vpp3xdl	26	16	type	type	NN
cord-007689-0vpp3xdl	26	17	I	-PRON-	PRP
cord-007689-0vpp3xdl	26	18	IFNs	ifn	NNS
cord-007689-0vpp3xdl	26	19	by	by	IN
cord-007689-0vpp3xdl	26	20	infected	infected	JJ
cord-007689-0vpp3xdl	26	21	host	host	NN
cord-007689-0vpp3xdl	26	22	cells	cell	NNS
cord-007689-0vpp3xdl	26	23	.	.	.
cord-007689-0vpp3xdl	27	1	However	however	RB
cord-007689-0vpp3xdl	27	2	,	,	,
cord-007689-0vpp3xdl	27	3	the	the	DT
cord-007689-0vpp3xdl	27	4	specific	specific	JJ
cord-007689-0vpp3xdl	27	5	host	host	NN
cord-007689-0vpp3xdl	27	6	immune	immune	JJ
cord-007689-0vpp3xdl	27	7	receptors	receptor	NNS
cord-007689-0vpp3xdl	27	8	and	and	CC
cord-007689-0vpp3xdl	27	9	their	-PRON-	PRP$
cord-007689-0vpp3xdl	27	10	respective	respective	JJ
cord-007689-0vpp3xdl	27	11	molecular	molecular	JJ
cord-007689-0vpp3xdl	27	12	ligands	ligand	NNS
cord-007689-0vpp3xdl	27	13	remained	remain	VBD
cord-007689-0vpp3xdl	27	14	elusive	elusive	JJ
cord-007689-0vpp3xdl	27	15	until	until	IN
cord-007689-0vpp3xdl	27	16	very	very	RB
cord-007689-0vpp3xdl	27	17	recently	recently	RB
cord-007689-0vpp3xdl	27	18	.	.	.
cord-007689-0vpp3xdl	28	1	Moreover	moreover	RB
cord-007689-0vpp3xdl	28	2	,	,	,
cord-007689-0vpp3xdl	28	3	to	to	TO
cord-007689-0vpp3xdl	28	4	mount	mount	VB
cord-007689-0vpp3xdl	28	5	an	an	DT
cord-007689-0vpp3xdl	28	6	appropriate	appropriate	JJ
cord-007689-0vpp3xdl	28	7	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	28	8	response	response	NN
cord-007689-0vpp3xdl	28	9	,	,	,
cord-007689-0vpp3xdl	28	10	the	the	DT
cord-007689-0vpp3xdl	28	11	innate	innate	JJ
cord-007689-0vpp3xdl	28	12	immune	immune	JJ
cord-007689-0vpp3xdl	28	13	system	system	NN
cord-007689-0vpp3xdl	28	14	must	must	MD
cord-007689-0vpp3xdl	28	15	distinguish	distinguish	VB
cord-007689-0vpp3xdl	28	16	viruses	virus	NNS
cord-007689-0vpp3xdl	28	17	from	from	IN
cord-007689-0vpp3xdl	28	18	bacteria	bacteria	NNS
cord-007689-0vpp3xdl	28	19	,	,	,
cord-007689-0vpp3xdl	28	20	fungi	fungus	NNS
cord-007689-0vpp3xdl	28	21	,	,	,
cord-007689-0vpp3xdl	28	22	and	and	CC
cord-007689-0vpp3xdl	28	23	multicellular	multicellular	JJ
cord-007689-0vpp3xdl	28	24	parasites	parasite	NNS
cord-007689-0vpp3xdl	28	25	.	.	.
cord-007689-0vpp3xdl	29	1	Charles	Charles	NNP
cord-007689-0vpp3xdl	29	2	Janeway	Janeway	NNP
cord-007689-0vpp3xdl	29	3	was	be	VBD
cord-007689-0vpp3xdl	29	4	the	the	DT
cord-007689-0vpp3xdl	29	5	first	first	JJ
cord-007689-0vpp3xdl	29	6	to	to	TO
cord-007689-0vpp3xdl	29	7	propose	propose	VB
cord-007689-0vpp3xdl	29	8	that	that	IN
cord-007689-0vpp3xdl	29	9	the	the	DT
cord-007689-0vpp3xdl	29	10	detection	detection	NN
cord-007689-0vpp3xdl	29	11	of	of	IN
cord-007689-0vpp3xdl	29	12	highly	highly	RB
cord-007689-0vpp3xdl	29	13	conserved	conserved	JJ
cord-007689-0vpp3xdl	29	14	pathogen	pathogen	NN
cord-007689-0vpp3xdl	29	15	-	-	HYPH
cord-007689-0vpp3xdl	29	16	associated	associate	VBN
cord-007689-0vpp3xdl	29	17	molecular	molecular	JJ
cord-007689-0vpp3xdl	29	18	patterns	pattern	NNS
cord-007689-0vpp3xdl	29	19	(	(	-LRB-
cord-007689-0vpp3xdl	29	20	PAMPs	pamp	NNS
cord-007689-0vpp3xdl	29	21	)	)	-RRB-
cord-007689-0vpp3xdl	29	22	may	may	MD
cord-007689-0vpp3xdl	29	23	be	be	VB
cord-007689-0vpp3xdl	29	24	mastered	master	VBN
cord-007689-0vpp3xdl	29	25	by	by	IN
cord-007689-0vpp3xdl	29	26	a	a	DT
cord-007689-0vpp3xdl	29	27	limited	limited	JJ
cord-007689-0vpp3xdl	29	28	number	number	NN
cord-007689-0vpp3xdl	29	29	of	of	IN
cord-007689-0vpp3xdl	29	30	germline	germline	NN
cord-007689-0vpp3xdl	29	31	-	-	HYPH
cord-007689-0vpp3xdl	29	32	encoded	encode	VBN
cord-007689-0vpp3xdl	29	33	pattern	pattern	NN
cord-007689-0vpp3xdl	29	34	recognition	recognition	NN
cord-007689-0vpp3xdl	29	35	receptors	receptor	NNS
cord-007689-0vpp3xdl	29	36	(	(	-LRB-
cord-007689-0vpp3xdl	29	37	PRRs	PRRs	NNP
cord-007689-0vpp3xdl	29	38	)	)	-RRB-
cord-007689-0vpp3xdl	29	39	(	(	-LRB-
cord-007689-0vpp3xdl	29	40	Janeway	Janeway	NNP
cord-007689-0vpp3xdl	29	41	1989	1989	CD
cord-007689-0vpp3xdl	29	42	)	)	-RRB-
cord-007689-0vpp3xdl	29	43	.	.	.
cord-007689-0vpp3xdl	30	1	A	a	DT
cord-007689-0vpp3xdl	30	2	few	few	JJ
cord-007689-0vpp3xdl	30	3	years	year	NNS
cord-007689-0vpp3xdl	30	4	later	later	RB
cord-007689-0vpp3xdl	30	5	,	,	,
cord-007689-0vpp3xdl	30	6	the	the	DT
cord-007689-0vpp3xdl	30	7	first	first	JJ
cord-007689-0vpp3xdl	30	8	experimental	experimental	JJ
cord-007689-0vpp3xdl	30	9	evidence	evidence	NN
cord-007689-0vpp3xdl	30	10	of	of	IN
cord-007689-0vpp3xdl	30	11	such	such	PDT
cord-007689-0vpp3xdl	30	12	a	a	DT
cord-007689-0vpp3xdl	30	13	receptor	receptor	NN
cord-007689-0vpp3xdl	30	14	came	come	VBD
cord-007689-0vpp3xdl	30	15	from	from	IN
cord-007689-0vpp3xdl	30	16	the	the	DT
cord-007689-0vpp3xdl	30	17	fruit	fruit	NN
cord-007689-0vpp3xdl	30	18	fly	fly	NN
cord-007689-0vpp3xdl	30	19	(	(	-LRB-
cord-007689-0vpp3xdl	30	20	Lemaitre	Lemaitre	NNP
cord-007689-0vpp3xdl	30	21	et	et	NNP
cord-007689-0vpp3xdl	30	22	al	al	NNP
cord-007689-0vpp3xdl	30	23	.	.	.
cord-007689-0vpp3xdl	30	24	1996	1996	CD
cord-007689-0vpp3xdl	30	25	)	)	-RRB-
cord-007689-0vpp3xdl	30	26	.	.	.
cord-007689-0vpp3xdl	31	1	Shortly	shortly	RB
cord-007689-0vpp3xdl	31	2	afterwards	afterwards	RB
cord-007689-0vpp3xdl	31	3	,	,	,
cord-007689-0vpp3xdl	31	4	a	a	DT
cord-007689-0vpp3xdl	31	5	member	member	NN
cord-007689-0vpp3xdl	31	6	of	of	IN
cord-007689-0vpp3xdl	31	7	the	the	DT
cord-007689-0vpp3xdl	31	8	family	family	NN
cord-007689-0vpp3xdl	31	9	of	of	IN
cord-007689-0vpp3xdl	31	10	toll	toll	NN
cord-007689-0vpp3xdl	31	11	-	-	HYPH
cord-007689-0vpp3xdl	31	12	like	like	JJ
cord-007689-0vpp3xdl	31	13	receptors	receptor	NNS
cord-007689-0vpp3xdl	31	14	(	(	-LRB-
cord-007689-0vpp3xdl	31	15	TLR	TLR	NNP
cord-007689-0vpp3xdl	31	16	)	)	-RRB-
cord-007689-0vpp3xdl	31	17	,	,	,
cord-007689-0vpp3xdl	31	18	the	the	DT
cord-007689-0vpp3xdl	31	19	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	31	20	homolog	homolog	NN
cord-007689-0vpp3xdl	31	21	of	of	IN
cord-007689-0vpp3xdl	31	22	Drosophila	Drosophila	NNP
cord-007689-0vpp3xdl	31	23	toll	toll	NN
cord-007689-0vpp3xdl	31	24	,	,	,
cord-007689-0vpp3xdl	31	25	was	be	VBD
cord-007689-0vpp3xdl	31	26	demonstrated	demonstrate	VBN
cord-007689-0vpp3xdl	31	27	to	to	TO
cord-007689-0vpp3xdl	31	28	be	be	VB
cord-007689-0vpp3xdl	31	29	responsible	responsible	JJ
cord-007689-0vpp3xdl	31	30	for	for	IN
cord-007689-0vpp3xdl	31	31	detecting	detect	VBG
cord-007689-0vpp3xdl	31	32	lipopolysaccharides	lipopolysaccharides	NNP
cord-007689-0vpp3xdl	31	33	(	(	-LRB-
cord-007689-0vpp3xdl	31	34	LPS	LPS	NNP
cord-007689-0vpp3xdl	31	35	)	)	-RRB-
cord-007689-0vpp3xdl	31	36	,	,	,
cord-007689-0vpp3xdl	31	37	a	a	DT
cord-007689-0vpp3xdl	31	38	characteristic	characteristic	JJ
cord-007689-0vpp3xdl	31	39	component	component	NN
cord-007689-0vpp3xdl	31	40	of	of	IN
cord-007689-0vpp3xdl	31	41	the	the	DT
cord-007689-0vpp3xdl	31	42	cell	cell	NN
cord-007689-0vpp3xdl	31	43	walls	wall	NNS
cord-007689-0vpp3xdl	31	44	of	of	IN
cord-007689-0vpp3xdl	31	45	Gram	gram	NN
cord-007689-0vpp3xdl	31	46	-	-	HYPH
cord-007689-0vpp3xdl	31	47	negative	negative	JJ
cord-007689-0vpp3xdl	31	48	bacteria	bacteria	NNS
cord-007689-0vpp3xdl	31	49	(	(	-LRB-
cord-007689-0vpp3xdl	31	50	Medzhitov	Medzhitov	NNP
cord-007689-0vpp3xdl	31	51	et	et	NNP
cord-007689-0vpp3xdl	31	52	al	al	NNP
cord-007689-0vpp3xdl	31	53	.	.	.
cord-007689-0vpp3xdl	31	54	1997	1997	CD
cord-007689-0vpp3xdl	31	55	;	;	:
cord-007689-0vpp3xdl	31	56	Poltorak	Poltorak	NNP
cord-007689-0vpp3xdl	31	57	et	et	NNP
cord-007689-0vpp3xdl	31	58	al	al	NNP
cord-007689-0vpp3xdl	31	59	.	.	NNP
cord-007689-0vpp3xdl	31	60	1998	1998	CD
cord-007689-0vpp3xdl	31	61	)	)	-RRB-
cord-007689-0vpp3xdl	31	62	.	.	.
cord-007689-0vpp3xdl	32	1	This	this	DT
cord-007689-0vpp3xdl	32	2	observation	observation	NN
cord-007689-0vpp3xdl	32	3	was	be	VBD
cord-007689-0vpp3xdl	32	4	confirmed	confirm	VBN
cord-007689-0vpp3xdl	32	5	by	by	IN
cord-007689-0vpp3xdl	32	6	the	the	DT
cord-007689-0vpp3xdl	32	7	subsequent	subsequent	JJ
cord-007689-0vpp3xdl	32	8	generation	generation	NN
cord-007689-0vpp3xdl	32	9	of	of	IN
cord-007689-0vpp3xdl	32	10	TLR4-deficient	TLR4-deficient	NNP
cord-007689-0vpp3xdl	32	11	mice	mouse	NNS
cord-007689-0vpp3xdl	32	12	(	(	-LRB-
cord-007689-0vpp3xdl	32	13	Hoshino	Hoshino	NNP
cord-007689-0vpp3xdl	32	14	et	et	FW
cord-007689-0vpp3xdl	32	15	al	al	NNP
cord-007689-0vpp3xdl	32	16	.	.	.
cord-007689-0vpp3xdl	32	17	1999	1999	CD
cord-007689-0vpp3xdl	32	18	)	)	-RRB-
cord-007689-0vpp3xdl	32	19	.	.	.
cord-007689-0vpp3xdl	33	1	Parasites	parasite	NNS
cord-007689-0vpp3xdl	33	2	,	,	,
cord-007689-0vpp3xdl	33	3	bacteria	bacteria	NNS
cord-007689-0vpp3xdl	33	4	,	,	,
cord-007689-0vpp3xdl	33	5	and	and	CC
cord-007689-0vpp3xdl	33	6	fungi	fungus	NNS
cord-007689-0vpp3xdl	33	7	rely	rely	VBP
cord-007689-0vpp3xdl	33	8	on	on	IN
cord-007689-0vpp3xdl	33	9	a	a	DT
cord-007689-0vpp3xdl	33	10	multitude	multitude	NN
cord-007689-0vpp3xdl	33	11	of	of	IN
cord-007689-0vpp3xdl	33	12	molecules	molecule	NNS
cord-007689-0vpp3xdl	33	13	that	that	WDT
cord-007689-0vpp3xdl	33	14	are	be	VBP
cord-007689-0vpp3xdl	33	15	distant	distant	JJ
cord-007689-0vpp3xdl	33	16	in	in	IN
cord-007689-0vpp3xdl	33	17	evolutionary	evolutionary	JJ
cord-007689-0vpp3xdl	33	18	terms	term	NNS
cord-007689-0vpp3xdl	33	19	from	from	IN
cord-007689-0vpp3xdl	33	20	the	the	DT
cord-007689-0vpp3xdl	33	21	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	33	22	organism	organism	NN
cord-007689-0vpp3xdl	33	23	,	,	,
cord-007689-0vpp3xdl	33	24	and	and	CC
cord-007689-0vpp3xdl	33	25	are	be	VBP
cord-007689-0vpp3xdl	33	26	thus	thus	RB
cord-007689-0vpp3xdl	33	27	readily	readily	RB
cord-007689-0vpp3xdl	33	28	discernible	discernible	JJ
cord-007689-0vpp3xdl	33	29	as	as	IN
cord-007689-0vpp3xdl	33	30	non	non	JJ
cord-007689-0vpp3xdl	33	31	-	-	JJ
cord-007689-0vpp3xdl	33	32	self	self	JJ
cord-007689-0vpp3xdl	33	33	by	by	IN
cord-007689-0vpp3xdl	33	34	members	member	NNS
cord-007689-0vpp3xdl	33	35	of	of	IN
cord-007689-0vpp3xdl	33	36	the	the	DT
cord-007689-0vpp3xdl	33	37	Toll	Toll	NNP
cord-007689-0vpp3xdl	33	38	-	-	HYPH
cord-007689-0vpp3xdl	33	39	like	like	JJ
cord-007689-0vpp3xdl	33	40	receptor	receptor	NN
cord-007689-0vpp3xdl	33	41	(	(	-LRB-
cord-007689-0vpp3xdl	33	42	TLR	TLR	NNP
cord-007689-0vpp3xdl	33	43	)	)	-RRB-
cord-007689-0vpp3xdl	33	44	and	and	CC
cord-007689-0vpp3xdl	33	45	NODlike	nodlike	NN
cord-007689-0vpp3xdl	33	46	receptor	receptor	NN
cord-007689-0vpp3xdl	33	47	(	(	-LRB-
cord-007689-0vpp3xdl	33	48	NLR	NLR	NNP
cord-007689-0vpp3xdl	33	49	)	)	-RRB-
cord-007689-0vpp3xdl	33	50	families	family	NNS
cord-007689-0vpp3xdl	33	51	(	(	-LRB-
cord-007689-0vpp3xdl	33	52	reviewed	review	VBN
cord-007689-0vpp3xdl	33	53	in	in	IN
cord-007689-0vpp3xdl	33	54	Meylan	Meylan	NNP
cord-007689-0vpp3xdl	33	55	et	et	NNP
cord-007689-0vpp3xdl	33	56	al	al	NNP
cord-007689-0vpp3xdl	33	57	.	.	NNP
cord-007689-0vpp3xdl	33	58	2005	2005	CD
cord-007689-0vpp3xdl	33	59	)	)	-RRB-
cord-007689-0vpp3xdl	33	60	.	.	.
cord-007689-0vpp3xdl	34	1	In	in	IN
cord-007689-0vpp3xdl	34	2	sharp	sharp	JJ
cord-007689-0vpp3xdl	34	3	contrast	contrast	NN
cord-007689-0vpp3xdl	34	4	,	,	,
cord-007689-0vpp3xdl	34	5	all	all	DT
cord-007689-0vpp3xdl	34	6	components	component	NNS
cord-007689-0vpp3xdl	34	7	of	of	IN
cord-007689-0vpp3xdl	34	8	viruses	virus	NNS
cord-007689-0vpp3xdl	34	9	are	be	VBP
cord-007689-0vpp3xdl	34	10	produced	produce	VBN
cord-007689-0vpp3xdl	34	11	within	within	IN
cord-007689-0vpp3xdl	34	12	the	the	DT
cord-007689-0vpp3xdl	34	13	infected	infected	JJ
cord-007689-0vpp3xdl	34	14	host	host	NN
cord-007689-0vpp3xdl	34	15	cell	cell	NN
cord-007689-0vpp3xdl	34	16	,	,	,
cord-007689-0vpp3xdl	34	17	and	and	CC
cord-007689-0vpp3xdl	34	18	therefore	therefore	RB
cord-007689-0vpp3xdl	34	19	lack	lack	VBP
cord-007689-0vpp3xdl	34	20	distinguishable	distinguishable	JJ
cord-007689-0vpp3xdl	34	21	non	non	JJ
cord-007689-0vpp3xdl	34	22	-	-	JJ
cord-007689-0vpp3xdl	34	23	self	self	JJ
cord-007689-0vpp3xdl	34	24	molecular	molecular	JJ
cord-007689-0vpp3xdl	34	25	patterns	pattern	NNS
cord-007689-0vpp3xdl	34	26	.	.	.
cord-007689-0vpp3xdl	35	1	Nevertheless	nevertheless	RB
cord-007689-0vpp3xdl	35	2	,	,	,
cord-007689-0vpp3xdl	35	3	viruses	virus	NNS
cord-007689-0vpp3xdl	35	4	are	be	VBP
cord-007689-0vpp3xdl	35	5	promptly	promptly	RB
cord-007689-0vpp3xdl	35	6	recognized	recognize	VBN
cord-007689-0vpp3xdl	35	7	by	by	IN
cord-007689-0vpp3xdl	35	8	the	the	DT
cord-007689-0vpp3xdl	35	9	innate	innate	JJ
cord-007689-0vpp3xdl	35	10	immune	immune	JJ
cord-007689-0vpp3xdl	35	11	system	system	NN
cord-007689-0vpp3xdl	35	12	and	and	CC
cord-007689-0vpp3xdl	35	13	elicit	elicit	VB
cord-007689-0vpp3xdl	35	14	pronounced	pronounce	VBN
cord-007689-0vpp3xdl	35	15	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	35	16	type	type	NN
cord-007689-0vpp3xdl	36	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	36	2	interferon	interferon	VBD
cord-007689-0vpp3xdl	36	3	and	and	CC
cord-007689-0vpp3xdl	36	4	cytokine	cytokine	NN
cord-007689-0vpp3xdl	36	5	responses	response	NNS
cord-007689-0vpp3xdl	36	6	.	.	.
cord-007689-0vpp3xdl	37	1	Shortly	shortly	RB
cord-007689-0vpp3xdl	37	2	after	after	IN
cord-007689-0vpp3xdl	37	3	the	the	DT
cord-007689-0vpp3xdl	37	4	discovery	discovery	NN
cord-007689-0vpp3xdl	37	5	of	of	IN
cord-007689-0vpp3xdl	37	6	type	type	NN
cord-007689-0vpp3xdl	37	7	I	-PRON-	PRP
cord-007689-0vpp3xdl	37	8	interferons	interferon	NNS
cord-007689-0vpp3xdl	37	9	,	,	,
cord-007689-0vpp3xdl	37	10	it	-PRON-	PRP
cord-007689-0vpp3xdl	37	11	was	be	VBD
cord-007689-0vpp3xdl	37	12	proposed	propose	VBN
cord-007689-0vpp3xdl	37	13	that	that	IN
cord-007689-0vpp3xdl	37	14	viral	viral	JJ
cord-007689-0vpp3xdl	37	15	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	37	16	acids	acid	NNS
cord-007689-0vpp3xdl	37	17	could	could	MD
cord-007689-0vpp3xdl	37	18	be	be	VB
cord-007689-0vpp3xdl	37	19	stimulating	stimulate	VBG
cord-007689-0vpp3xdl	37	20	the	the	DT
cord-007689-0vpp3xdl	37	21	type	type	NN
cord-007689-0vpp3xdl	37	22	I	-PRON-	PRP
cord-007689-0vpp3xdl	37	23	IFN	IFN	NNP
cord-007689-0vpp3xdl	37	24	response	response	NN
cord-007689-0vpp3xdl	37	25	(	(	-LRB-
cord-007689-0vpp3xdl	38	1	Isaacs	Isaacs	NNP
cord-007689-0vpp3xdl	38	2	et	et	NNP
cord-007689-0vpp3xdl	38	3	al	al	NNP
cord-007689-0vpp3xdl	38	4	.	.	.
cord-007689-0vpp3xdl	38	5	1963	1963	CD
cord-007689-0vpp3xdl	38	6	)	)	-RRB-
cord-007689-0vpp3xdl	38	7	.	.	.
cord-007689-0vpp3xdl	39	1	Many	many	JJ
cord-007689-0vpp3xdl	39	2	viruses	virus	NNS
cord-007689-0vpp3xdl	39	3	synthesize	synthesize	VBP
cord-007689-0vpp3xdl	39	4	double	double	RB
cord-007689-0vpp3xdl	39	5	-	-	HYPH
cord-007689-0vpp3xdl	39	6	stranded	strand	VBN
cord-007689-0vpp3xdl	39	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	39	8	(	(	-LRB-
cord-007689-0vpp3xdl	39	9	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	39	10	)	)	-RRB-
cord-007689-0vpp3xdl	39	11	during	during	IN
cord-007689-0vpp3xdl	39	12	their	-PRON-	PRP$
cord-007689-0vpp3xdl	39	13	replication	replication	NN
cord-007689-0vpp3xdl	39	14	cycle	cycle	NN
cord-007689-0vpp3xdl	39	15	(	(	-LRB-
cord-007689-0vpp3xdl	39	16	Baltimore	Baltimore	NNP
cord-007689-0vpp3xdl	39	17	et	et	NNP
cord-007689-0vpp3xdl	39	18	al	al	NNP
cord-007689-0vpp3xdl	39	19	.	.	.
cord-007689-0vpp3xdl	39	20	1964	1964	CD
cord-007689-0vpp3xdl	39	21	;	;	:
cord-007689-0vpp3xdl	39	22	Montagnier	Montagnier	NNP
cord-007689-0vpp3xdl	39	23	and	and	CC
cord-007689-0vpp3xdl	39	24	Sanders	Sanders	NNP
cord-007689-0vpp3xdl	39	25	1963	1963	CD
cord-007689-0vpp3xdl	39	26	)	)	-RRB-
cord-007689-0vpp3xdl	39	27	,	,	,
cord-007689-0vpp3xdl	39	28	whereas	whereas	IN
cord-007689-0vpp3xdl	39	29	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	39	30	was	be	VBD
cord-007689-0vpp3xdl	39	31	thought	think	VBN
cord-007689-0vpp3xdl	39	32	to	to	TO
cord-007689-0vpp3xdl	39	33	be	be	VB
cord-007689-0vpp3xdl	39	34	absent	absent	JJ
cord-007689-0vpp3xdl	39	35	in	in	IN
cord-007689-0vpp3xdl	39	36	uninfected	uninfected	JJ
cord-007689-0vpp3xdl	39	37	cells	cell	NNS
cord-007689-0vpp3xdl	39	38	.	.	.
cord-007689-0vpp3xdl	40	1	Therefore	therefore	RB
cord-007689-0vpp3xdl	40	2	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	40	3	formed	form	VBN
cord-007689-0vpp3xdl	40	4	during	during	IN
cord-007689-0vpp3xdl	40	5	viral	viral	JJ
cord-007689-0vpp3xdl	40	6	infection	infection	NN
cord-007689-0vpp3xdl	40	7	was	be	VBD
cord-007689-0vpp3xdl	40	8	postulated	postulate	VBN
cord-007689-0vpp3xdl	40	9	to	to	TO
cord-007689-0vpp3xdl	40	10	be	be	VB
cord-007689-0vpp3xdl	40	11	the	the	DT
cord-007689-0vpp3xdl	40	12	molecular	molecular	JJ
cord-007689-0vpp3xdl	40	13	signature	signature	NN
cord-007689-0vpp3xdl	40	14	of	of	IN
cord-007689-0vpp3xdl	40	15	viral	viral	JJ
cord-007689-0vpp3xdl	40	16	infection	infection	NN
cord-007689-0vpp3xdl	40	17	.	.	.
cord-007689-0vpp3xdl	41	1	In	in	IN
cord-007689-0vpp3xdl	41	2	support	support	NN
cord-007689-0vpp3xdl	41	3	of	of	IN
cord-007689-0vpp3xdl	41	4	this	this	DT
cord-007689-0vpp3xdl	41	5	hypothesis	hypothesis	NN
cord-007689-0vpp3xdl	41	6	,	,	,
cord-007689-0vpp3xdl	41	7	the	the	DT
cord-007689-0vpp3xdl	41	8	enzymatically	enzymatically	RB
cord-007689-0vpp3xdl	41	9	generated	generate	VBN
cord-007689-0vpp3xdl	41	10	double	double	RB
cord-007689-0vpp3xdl	41	11	-	-	HYPH
cord-007689-0vpp3xdl	41	12	stranded	strand	VBN
cord-007689-0vpp3xdl	41	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	41	14	polynucleotide	polynucleotide	IN
cord-007689-0vpp3xdl	41	15	polyinosinic	polyinosinic	NNP
cord-007689-0vpp3xdl	41	16	:	:	:
cord-007689-0vpp3xdl	41	17	polycytidylic	polycytidylic	NNP
cord-007689-0vpp3xdl	41	18	acid	acid	NNP
cord-007689-0vpp3xdl	41	19	(	(	-LRB-
cord-007689-0vpp3xdl	41	20	poly	poly	NN
cord-007689-0vpp3xdl	41	21	I	i	NN
cord-007689-0vpp3xdl	41	22	:	:	:
cord-007689-0vpp3xdl	41	23	C	C	NNP
cord-007689-0vpp3xdl	41	24	)	)	-RRB-
cord-007689-0vpp3xdl	41	25	was	be	VBD
cord-007689-0vpp3xdl	41	26	found	find	VBN
cord-007689-0vpp3xdl	41	27	to	to	TO
cord-007689-0vpp3xdl	41	28	be	be	VB
cord-007689-0vpp3xdl	41	29	a	a	DT
cord-007689-0vpp3xdl	41	30	potent	potent	JJ
cord-007689-0vpp3xdl	41	31	inducer	inducer	NN
cord-007689-0vpp3xdl	41	32	of	of	IN
cord-007689-0vpp3xdl	41	33	type	type	NN
cord-007689-0vpp3xdl	42	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	42	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	42	3	(	(	-LRB-
cord-007689-0vpp3xdl	42	4	Field	Field	NNP
cord-007689-0vpp3xdl	42	5	et	et	FW
cord-007689-0vpp3xdl	42	6	al	al	NNP
cord-007689-0vpp3xdl	42	7	.	.	.
cord-007689-0vpp3xdl	42	8	1967	1967	CD
cord-007689-0vpp3xdl	42	9	)	)	-RRB-
cord-007689-0vpp3xdl	42	10	.	.	.
cord-007689-0vpp3xdl	43	1	Although	although	IN
cord-007689-0vpp3xdl	43	2	the	the	DT
cord-007689-0vpp3xdl	43	3	authors	author	NNS
cord-007689-0vpp3xdl	43	4	carefully	carefully	RB
cord-007689-0vpp3xdl	43	5	emphasized	emphasize	VBD
cord-007689-0vpp3xdl	43	6	that	that	IN
cord-007689-0vpp3xdl	43	7	all	all	DT
cord-007689-0vpp3xdl	43	8	other	other	JJ
cord-007689-0vpp3xdl	43	9	double	double	RB
cord-007689-0vpp3xdl	43	10	-	-	HYPH
cord-007689-0vpp3xdl	43	11	stranded	strand	VBN
cord-007689-0vpp3xdl	43	12	polynucleotides	polynucleotide	NNS
cord-007689-0vpp3xdl	43	13	were	be	VBD
cord-007689-0vpp3xdl	43	14	inactive	inactive	JJ
cord-007689-0vpp3xdl	43	15	,	,	,
cord-007689-0vpp3xdl	43	16	the	the	DT
cord-007689-0vpp3xdl	43	17	notion	notion	NN
cord-007689-0vpp3xdl	43	18	that	that	IN
cord-007689-0vpp3xdl	43	19	long	long	JJ
cord-007689-0vpp3xdl	43	20	viral	viral	JJ
cord-007689-0vpp3xdl	43	21	double	double	RB
cord-007689-0vpp3xdl	43	22	-	-	HYPH
cord-007689-0vpp3xdl	43	23	stranded	strand	VBN
cord-007689-0vpp3xdl	43	24	RNA	RNA	NNP
cord-007689-0vpp3xdl	43	25	elicits	elicit	VBZ
cord-007689-0vpp3xdl	43	26	type	type	NN
cord-007689-0vpp3xdl	43	27	I	-PRON-	PRP
cord-007689-0vpp3xdl	43	28	IFN	IFN	NNP
cord-007689-0vpp3xdl	43	29	became	become	VBD
cord-007689-0vpp3xdl	43	30	commonplace	commonplace	JJ
cord-007689-0vpp3xdl	43	31	,	,	,
cord-007689-0vpp3xdl	43	32	and	and	CC
cord-007689-0vpp3xdl	43	33	poly	poly	NN
cord-007689-0vpp3xdl	43	34	I	i	NN
cord-007689-0vpp3xdl	43	35	:	:	:
cord-007689-0vpp3xdl	43	36	C	C	NNP
cord-007689-0vpp3xdl	43	37	has	have	VBZ
cord-007689-0vpp3xdl	43	38	been	be	VBN
cord-007689-0vpp3xdl	43	39	used	use	VBN
cord-007689-0vpp3xdl	43	40	as	as	IN
cord-007689-0vpp3xdl	43	41	an	an	DT
cord-007689-0vpp3xdl	43	42	interferon	interferon	NN
cord-007689-0vpp3xdl	43	43	-	-	HYPH
cord-007689-0vpp3xdl	43	44	inducing	induce	VBG
cord-007689-0vpp3xdl	43	45	mimic	mimic	NN
cord-007689-0vpp3xdl	43	46	of	of	IN
cord-007689-0vpp3xdl	43	47	viral	viral	JJ
cord-007689-0vpp3xdl	43	48	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	43	49	ever	ever	RB
cord-007689-0vpp3xdl	43	50	since	since	RB
cord-007689-0vpp3xdl	43	51	.	.	.
cord-007689-0vpp3xdl	44	1	In	in	IN
cord-007689-0vpp3xdl	44	2	early	early	JJ
cord-007689-0vpp3xdl	44	3	attempts	attempt	NNS
cord-007689-0vpp3xdl	44	4	to	to	TO
cord-007689-0vpp3xdl	44	5	uncover	uncover	VB
cord-007689-0vpp3xdl	44	6	the	the	DT
cord-007689-0vpp3xdl	44	7	inducers	inducer	NNS
cord-007689-0vpp3xdl	44	8	of	of	IN
cord-007689-0vpp3xdl	44	9	interferon	interferon	NN
cord-007689-0vpp3xdl	44	10	and	and	CC
cord-007689-0vpp3xdl	44	11	of	of	IN
cord-007689-0vpp3xdl	44	12	other	other	JJ
cord-007689-0vpp3xdl	44	13	mediators	mediator	NNS
cord-007689-0vpp3xdl	44	14	of	of	IN
cord-007689-0vpp3xdl	44	15	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	44	16	activity	activity	NN
cord-007689-0vpp3xdl	44	17	,	,	,
cord-007689-0vpp3xdl	44	18	IFN	IFN	NNP
cord-007689-0vpp3xdl	44	19	-	-	HYPH
cord-007689-0vpp3xdl	44	20	α	α	NNP
cord-007689-0vpp3xdl	44	21	and	and	CC
cord-007689-0vpp3xdl	44	22	poly	poly	NNP
cord-007689-0vpp3xdl	44	23	I	i	NN
cord-007689-0vpp3xdl	44	24	:	:	:
cord-007689-0vpp3xdl	44	25	C	c	NN
cord-007689-0vpp3xdl	44	26	-	-	HYPH
cord-007689-0vpp3xdl	44	27	treated	treat	VBN
cord-007689-0vpp3xdl	44	28	or	or	CC
cord-007689-0vpp3xdl	44	29	reticulocyte	reticulocyte	NN
cord-007689-0vpp3xdl	44	30	extracts	extract	NNS
cord-007689-0vpp3xdl	44	31	were	be	VBD
cord-007689-0vpp3xdl	44	32	analyzed	analyze	VBN
cord-007689-0vpp3xdl	44	33	.	.	.
cord-007689-0vpp3xdl	45	1	Chromatographic	chromatographic	JJ
cord-007689-0vpp3xdl	45	2	separation	separation	NN
cord-007689-0vpp3xdl	45	3	of	of	IN
cord-007689-0vpp3xdl	45	4	lysates	lysate	NNS
cord-007689-0vpp3xdl	45	5	revealed	reveal	VBD
cord-007689-0vpp3xdl	45	6	proteins	protein	NNS
cord-007689-0vpp3xdl	45	7	that	that	WDT
cord-007689-0vpp3xdl	45	8	were	be	VBD
cord-007689-0vpp3xdl	45	9	increased	increase	VBN
cord-007689-0vpp3xdl	45	10	by	by	IN
cord-007689-0vpp3xdl	45	11	preincubation	preincubation	NN
cord-007689-0vpp3xdl	45	12	with	with	IN
cord-007689-0vpp3xdl	45	13	IFN	IFN	NNP
cord-007689-0vpp3xdl	45	14	-	-	HYPH
cord-007689-0vpp3xdl	45	15	α	α	NNP
cord-007689-0vpp3xdl	45	16	,	,	,
cord-007689-0vpp3xdl	45	17	and	and	CC
cord-007689-0vpp3xdl	45	18	whose	whose	WP$
cord-007689-0vpp3xdl	45	19	enzymatic	enzymatic	JJ
cord-007689-0vpp3xdl	45	20	activity	activity	NN
cord-007689-0vpp3xdl	45	21	depended	depend	VBD
cord-007689-0vpp3xdl	45	22	on	on	IN
cord-007689-0vpp3xdl	45	23	the	the	DT
cord-007689-0vpp3xdl	45	24	presence	presence	NN
cord-007689-0vpp3xdl	45	25	of	of	IN
cord-007689-0vpp3xdl	45	26	dsRNA	dsRNA	VBG
cord-007689-0vpp3xdl	45	27	(	(	-LRB-
cord-007689-0vpp3xdl	45	28	usually	usually	RB
cord-007689-0vpp3xdl	45	29	poly	poly	JJ
cord-007689-0vpp3xdl	45	30	I	i	NN
cord-007689-0vpp3xdl	45	31	:	:	:
cord-007689-0vpp3xdl	45	32	C	C	NNP
cord-007689-0vpp3xdl	45	33	)	)	-RRB-
cord-007689-0vpp3xdl	46	1	(	(	-LRB-
cord-007689-0vpp3xdl	46	2	Farrell	Farrell	NNP
cord-007689-0vpp3xdl	46	3	et	et	NNP
cord-007689-0vpp3xdl	46	4	al	al	NNP
cord-007689-0vpp3xdl	46	5	.	.	.
cord-007689-0vpp3xdl	46	6	1978	1978	CD
cord-007689-0vpp3xdl	47	1	;	;	:
cord-007689-0vpp3xdl	47	2	Hovanessian	Hovanessian	NNP
cord-007689-0vpp3xdl	47	3	et	et	NNP
cord-007689-0vpp3xdl	47	4	al	al	NNP
cord-007689-0vpp3xdl	47	5	.	.	.
cord-007689-0vpp3xdl	48	1	1977	1977	CD
cord-007689-0vpp3xdl	48	2	;	;	:
cord-007689-0vpp3xdl	48	3	Zilberstein	Zilberstein	NNP
cord-007689-0vpp3xdl	48	4	et	et	NNP
cord-007689-0vpp3xdl	48	5	al	al	NNP
cord-007689-0vpp3xdl	48	6	.	.	.
cord-007689-0vpp3xdl	48	7	1978	1978	CD
cord-007689-0vpp3xdl	48	8	)	)	-RRB-
cord-007689-0vpp3xdl	48	9	.	.	.
cord-007689-0vpp3xdl	49	1	Two	two	CD
cord-007689-0vpp3xdl	49	2	proteins	protein	NNS
cord-007689-0vpp3xdl	49	3	,	,	,
cord-007689-0vpp3xdl	49	4	interferon	interferon	NN
cord-007689-0vpp3xdl	49	5	inducible	inducible	JJ
cord-007689-0vpp3xdl	49	6	double	double	RB
cord-007689-0vpp3xdl	49	7	-	-	HYPH
cord-007689-0vpp3xdl	49	8	stranded	strand	VBN
cord-007689-0vpp3xdl	49	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	49	10	-	-	HYPH
cord-007689-0vpp3xdl	49	11	activated	activate	VBN
cord-007689-0vpp3xdl	49	12	protein	protein	NN
cord-007689-0vpp3xdl	49	13	kinase	kinase	NN
cord-007689-0vpp3xdl	49	14	(	(	-LRB-
cord-007689-0vpp3xdl	49	15	PKR	PKR	NNP
cord-007689-0vpp3xdl	49	16	)	)	-RRB-
cord-007689-0vpp3xdl	49	17	and	and	CC
cord-007689-0vpp3xdl	49	18	the	the	DT
cord-007689-0vpp3xdl	49	19	2′,5′	2′,5′	CD
cord-007689-0vpp3xdl	49	20	oligoadenylate	oligoadenylate	NNP
cord-007689-0vpp3xdl	49	21	synthetase	synthetase	NNP
cord-007689-0vpp3xdl	49	22	(	(	-LRB-
cord-007689-0vpp3xdl	49	23	OAS	OAS	NNP
cord-007689-0vpp3xdl	49	24	)	)	-RRB-
cord-007689-0vpp3xdl	49	25	could	could	MD
cord-007689-0vpp3xdl	49	26	be	be	VB
cord-007689-0vpp3xdl	49	27	affinity	affinity	NN
cord-007689-0vpp3xdl	49	28	purified	purify	VBN
cord-007689-0vpp3xdl	49	29	using	use	VBG
cord-007689-0vpp3xdl	49	30	poly	poly	NNP
cord-007689-0vpp3xdl	50	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	50	2	:	:	:
cord-007689-0vpp3xdl	50	3	C	c	NN
cord-007689-0vpp3xdl	50	4	-	-	HYPH
cord-007689-0vpp3xdl	50	5	cellulose	cellulose	NN
cord-007689-0vpp3xdl	50	6	(	(	-LRB-
cord-007689-0vpp3xdl	50	7	Farrell	Farrell	NNP
cord-007689-0vpp3xdl	50	8	et	et	NNP
cord-007689-0vpp3xdl	50	9	al	al	NNP
cord-007689-0vpp3xdl	50	10	.	.	.
cord-007689-0vpp3xdl	50	11	1978	1978	CD
cord-007689-0vpp3xdl	50	12	;	;	:
cord-007689-0vpp3xdl	50	13	Hovanessian	Hovanessian	NNP
cord-007689-0vpp3xdl	50	14	et	et	NNP
cord-007689-0vpp3xdl	50	15	al	al	NNP
cord-007689-0vpp3xdl	50	16	.	.	NNP
cord-007689-0vpp3xdl	50	17	1977	1977	CD
cord-007689-0vpp3xdl	50	18	)	)	-RRB-
cord-007689-0vpp3xdl	50	19	.	.	.
cord-007689-0vpp3xdl	51	1	Both	both	DT
cord-007689-0vpp3xdl	51	2	activated	activate	VBD
cord-007689-0vpp3xdl	51	3	PKR	PKR	NNP
cord-007689-0vpp3xdl	51	4	and	and	CC
cord-007689-0vpp3xdl	51	5	OAS	OAS	NNP
cord-007689-0vpp3xdl	51	6	were	be	VBD
cord-007689-0vpp3xdl	51	7	found	find	VBN
cord-007689-0vpp3xdl	51	8	to	to	TO
cord-007689-0vpp3xdl	51	9	block	block	VB
cord-007689-0vpp3xdl	51	10	translation	translation	NN
cord-007689-0vpp3xdl	51	11	of	of	IN
cord-007689-0vpp3xdl	51	12	viral	viral	JJ
cord-007689-0vpp3xdl	51	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	51	14	by	by	IN
cord-007689-0vpp3xdl	51	15	distinct	distinct	JJ
cord-007689-0vpp3xdl	51	16	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	51	17	.	.	.
cord-007689-0vpp3xdl	52	1	In	in	IN
cord-007689-0vpp3xdl	52	2	the	the	DT
cord-007689-0vpp3xdl	52	3	presence	presence	NN
cord-007689-0vpp3xdl	52	4	of	of	IN
cord-007689-0vpp3xdl	52	5	poly	poly	NNP
cord-007689-0vpp3xdl	52	6	I	i	NN
cord-007689-0vpp3xdl	52	7	:	:	:
cord-007689-0vpp3xdl	52	8	C	C	NNP
cord-007689-0vpp3xdl	53	1	,	,	,
cord-007689-0vpp3xdl	53	2	OAS	OAS	NNP
cord-007689-0vpp3xdl	53	3	catalyzes	catalyze	VBZ
cord-007689-0vpp3xdl	53	4	the	the	DT
cord-007689-0vpp3xdl	53	5	synthesis	synthesis	NN
cord-007689-0vpp3xdl	53	6	of	of	IN
cord-007689-0vpp3xdl	53	7	2′,5′	2′,5′	CD
cord-007689-0vpp3xdl	53	8	oligomers	oligomer	NNS
cord-007689-0vpp3xdl	53	9	of	of	IN
cord-007689-0vpp3xdl	53	10	adenosine	adenosine	NN
cord-007689-0vpp3xdl	53	11	(	(	-LRB-
cord-007689-0vpp3xdl	53	12	2	2	CD
cord-007689-0vpp3xdl	53	13	-	-	HYPH
cord-007689-0vpp3xdl	53	14	5As	5as	JJ
cord-007689-0vpp3xdl	53	15	)	)	-RRB-
cord-007689-0vpp3xdl	54	1	(	(	-LRB-
cord-007689-0vpp3xdl	54	2	Hovanessian	Hovanessian	NNP
cord-007689-0vpp3xdl	54	3	et	et	FW
cord-007689-0vpp3xdl	54	4	al	al	NNP
cord-007689-0vpp3xdl	54	5	.	.	.
cord-007689-0vpp3xdl	55	1	1977	1977	CD
cord-007689-0vpp3xdl	55	2	;	;	:
cord-007689-0vpp3xdl	55	3	Zilberstein	Zilberstein	NNP
cord-007689-0vpp3xdl	55	4	et	et	NNP
cord-007689-0vpp3xdl	55	5	al	al	NNP
cord-007689-0vpp3xdl	55	6	.	.	.
cord-007689-0vpp3xdl	55	7	1978	1978	CD
cord-007689-0vpp3xdl	55	8	)	)	-RRB-
cord-007689-0vpp3xdl	55	9	,	,	,
cord-007689-0vpp3xdl	55	10	which	which	WDT
cord-007689-0vpp3xdl	55	11	activate	activate	VBP
cord-007689-0vpp3xdl	55	12	RNase	RNase	NNP
cord-007689-0vpp3xdl	55	13	L	L	NNP
cord-007689-0vpp3xdl	55	14	(	(	-LRB-
cord-007689-0vpp3xdl	55	15	Farrell	Farrell	NNP
cord-007689-0vpp3xdl	55	16	et	et	NNP
cord-007689-0vpp3xdl	55	17	al	al	NNP
cord-007689-0vpp3xdl	55	18	.	.	.
cord-007689-0vpp3xdl	55	19	1978	1978	CD
cord-007689-0vpp3xdl	55	20	)	)	-RRB-
cord-007689-0vpp3xdl	55	21	.	.	.
cord-007689-0vpp3xdl	56	1	RNase	RNase	NNP
cord-007689-0vpp3xdl	56	2	L	L	NNP
cord-007689-0vpp3xdl	56	3	in	in	IN
cord-007689-0vpp3xdl	56	4	turn	turn	NN
cord-007689-0vpp3xdl	56	5	degrades	degrade	VBZ
cord-007689-0vpp3xdl	56	6	single	single	RB
cord-007689-0vpp3xdl	56	7	-	-	HYPH
cord-007689-0vpp3xdl	56	8	stranded	strand	VBN
cord-007689-0vpp3xdl	56	9	viral	viral	JJ
cord-007689-0vpp3xdl	56	10	and	and	CC
cord-007689-0vpp3xdl	56	11	cellular	cellular	JJ
cord-007689-0vpp3xdl	56	12	RNAs	rna	NNS
cord-007689-0vpp3xdl	56	13	(	(	-LRB-
cord-007689-0vpp3xdl	56	14	Farrell	Farrell	NNP
cord-007689-0vpp3xdl	56	15	et	et	NNP
cord-007689-0vpp3xdl	56	16	al	al	NNP
cord-007689-0vpp3xdl	56	17	.	.	.
cord-007689-0vpp3xdl	56	18	1978	1978	CD
cord-007689-0vpp3xdl	56	19	)	)	-RRB-
cord-007689-0vpp3xdl	56	20	in	in	IN
cord-007689-0vpp3xdl	56	21	a	a	DT
cord-007689-0vpp3xdl	56	22	sequence	sequence	NN
cord-007689-0vpp3xdl	56	23	-	-	HYPH
cord-007689-0vpp3xdl	56	24	independent	independent	JJ
cord-007689-0vpp3xdl	56	25	manner	manner	NN
cord-007689-0vpp3xdl	56	26	(	(	-LRB-
cord-007689-0vpp3xdl	56	27	Minks	Minks	NNP
cord-007689-0vpp3xdl	56	28	et	et	NNP
cord-007689-0vpp3xdl	56	29	al	al	NNP
cord-007689-0vpp3xdl	56	30	.	.	.
cord-007689-0vpp3xdl	56	31	1979	1979	CD
cord-007689-0vpp3xdl	56	32	)	)	-RRB-
cord-007689-0vpp3xdl	56	33	.	.	.
cord-007689-0vpp3xdl	57	1	Consequently	consequently	RB
cord-007689-0vpp3xdl	57	2	RNase	RNase	NNP
cord-007689-0vpp3xdl	57	3	L	l	NN
cord-007689-0vpp3xdl	57	4	-	-	HYPH
cord-007689-0vpp3xdl	57	5	deficient	deficient	JJ
cord-007689-0vpp3xdl	57	6	mice	mouse	NNS
cord-007689-0vpp3xdl	57	7	displayed	display	VBD
cord-007689-0vpp3xdl	57	8	a	a	DT
cord-007689-0vpp3xdl	57	9	reduced	reduce	VBN
cord-007689-0vpp3xdl	57	10	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	57	11	activity	activity	NN
cord-007689-0vpp3xdl	57	12	of	of	IN
cord-007689-0vpp3xdl	57	13	IFN	IFN	NNP
cord-007689-0vpp3xdl	57	14	-	-	HYPH
cord-007689-0vpp3xdl	57	15	α	α	NNP
cord-007689-0vpp3xdl	57	16	,	,	,
cord-007689-0vpp3xdl	57	17	as	as	RB
cord-007689-0vpp3xdl	57	18	well	well	RB
cord-007689-0vpp3xdl	57	19	as	as	IN
cord-007689-0vpp3xdl	57	20	impaired	impaired	JJ
cord-007689-0vpp3xdl	57	21	apoptosis	apoptosis	NN
cord-007689-0vpp3xdl	57	22	(	(	-LRB-
cord-007689-0vpp3xdl	57	23	Zhou	Zhou	NNP
cord-007689-0vpp3xdl	57	24	et	et	NNP
cord-007689-0vpp3xdl	57	25	al	al	NNP
cord-007689-0vpp3xdl	57	26	.	.	.
cord-007689-0vpp3xdl	57	27	1997	1997	CD
cord-007689-0vpp3xdl	57	28	)	)	-RRB-
cord-007689-0vpp3xdl	57	29	.	.	.
cord-007689-0vpp3xdl	58	1	In	in	IN
cord-007689-0vpp3xdl	58	2	contrast	contrast	NN
cord-007689-0vpp3xdl	58	3	,	,	,
cord-007689-0vpp3xdl	58	4	the	the	DT
cord-007689-0vpp3xdl	58	5	serine	serine	JJ
cord-007689-0vpp3xdl	58	6	threonine	threonine	NN
cord-007689-0vpp3xdl	58	7	kinase	kinase	NN
cord-007689-0vpp3xdl	58	8	PKR	PKR	NNP
cord-007689-0vpp3xdl	58	9	was	be	VBD
cord-007689-0vpp3xdl	58	10	found	find	VBN
cord-007689-0vpp3xdl	58	11	to	to	IN
cord-007689-0vpp3xdl	58	12	more	more	RBR
cord-007689-0vpp3xdl	58	13	specifically	specifically	RB
cord-007689-0vpp3xdl	58	14	block	block	VB
cord-007689-0vpp3xdl	58	15	the	the	DT
cord-007689-0vpp3xdl	58	16	translation	translation	NN
cord-007689-0vpp3xdl	58	17	of	of	IN
cord-007689-0vpp3xdl	58	18	viral	viral	JJ
cord-007689-0vpp3xdl	58	19	RNA	RNA	NNP
cord-007689-0vpp3xdl	58	20	(	(	-LRB-
cord-007689-0vpp3xdl	58	21	Farrell	Farrell	NNP
cord-007689-0vpp3xdl	58	22	et	et	NNP
cord-007689-0vpp3xdl	58	23	al	al	NNP
cord-007689-0vpp3xdl	58	24	.	.	.
cord-007689-0vpp3xdl	58	25	1978	1978	CD
cord-007689-0vpp3xdl	58	26	)	)	-RRB-
cord-007689-0vpp3xdl	58	27	by	by	IN
cord-007689-0vpp3xdl	58	28	phosphorylation	phosphorylation	NN
cord-007689-0vpp3xdl	58	29	of	of	IN
cord-007689-0vpp3xdl	58	30	the	the	DT
cord-007689-0vpp3xdl	58	31	eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	58	32	translation	translation	NN
cord-007689-0vpp3xdl	58	33	initiation	initiation	NN
cord-007689-0vpp3xdl	58	34	factor	factor	NN
cord-007689-0vpp3xdl	58	35	eIF2a	eIF2a	NNP
cord-007689-0vpp3xdl	58	36	.	.	.
cord-007689-0vpp3xdl	59	1	Besides	besides	IN
cord-007689-0vpp3xdl	59	2	its	-PRON-	PRP$
cord-007689-0vpp3xdl	59	3	function	function	NN
cord-007689-0vpp3xdl	59	4	in	in	IN
cord-007689-0vpp3xdl	59	5	limiting	limit	VBG
cord-007689-0vpp3xdl	59	6	translation	translation	NN
cord-007689-0vpp3xdl	59	7	of	of	IN
cord-007689-0vpp3xdl	59	8	viral	viral	JJ
cord-007689-0vpp3xdl	59	9	protein	protein	NN
cord-007689-0vpp3xdl	59	10	,	,	,
cord-007689-0vpp3xdl	59	11	PKR	PKR	NNP
cord-007689-0vpp3xdl	59	12	was	be	VBD
cord-007689-0vpp3xdl	59	13	also	also	RB
cord-007689-0vpp3xdl	59	14	reported	report	VBN
cord-007689-0vpp3xdl	59	15	to	to	TO
cord-007689-0vpp3xdl	59	16	activate	activate	VB
cord-007689-0vpp3xdl	59	17	NF	NF	NNP
cord-007689-0vpp3xdl	59	18	-	-	HYPH
cord-007689-0vpp3xdl	59	19	κB	κB	NNP
cord-007689-0vpp3xdl	59	20	(	(	-LRB-
cord-007689-0vpp3xdl	59	21	Kumar	Kumar	NNP
cord-007689-0vpp3xdl	59	22	et	et	NNP
cord-007689-0vpp3xdl	59	23	al	al	NNP
cord-007689-0vpp3xdl	59	24	.	.	.
cord-007689-0vpp3xdl	59	25	1994	1994	CD
cord-007689-0vpp3xdl	59	26	)	)	-RRB-
cord-007689-0vpp3xdl	59	27	.	.	.
cord-007689-0vpp3xdl	60	1	PKR	PKR	NNP
cord-007689-0vpp3xdl	60	2	was	be	VBD
cord-007689-0vpp3xdl	60	3	therefore	therefore	RB
cord-007689-0vpp3xdl	60	4	proposed	propose	VBN
cord-007689-0vpp3xdl	60	5	as	as	IN
cord-007689-0vpp3xdl	60	6	a	a	DT
cord-007689-0vpp3xdl	60	7	key	key	JJ
cord-007689-0vpp3xdl	60	8	receptor	receptor	NN
cord-007689-0vpp3xdl	60	9	mediating	mediate	VBG
cord-007689-0vpp3xdl	60	10	virus	virus	NN
cord-007689-0vpp3xdl	60	11	-	-	:
cord-007689-0vpp3xdl	60	12	and	and	CC
cord-007689-0vpp3xdl	60	13	dsRNA	dsrna	RB
cord-007689-0vpp3xdl	60	14	-	-	HYPH
cord-007689-0vpp3xdl	60	15	induced	induce	VBN
cord-007689-0vpp3xdl	60	16	production	production	NN
cord-007689-0vpp3xdl	60	17	of	of	IN
cord-007689-0vpp3xdl	60	18	type	type	NN
cord-007689-0vpp3xdl	60	19	I	-PRON-	PRP
cord-007689-0vpp3xdl	60	20	interferons	interferon	NNS
cord-007689-0vpp3xdl	60	21	(	(	-LRB-
cord-007689-0vpp3xdl	60	22	Kumar	Kumar	NNP
cord-007689-0vpp3xdl	60	23	et	et	NNP
cord-007689-0vpp3xdl	60	24	al	al	NNP
cord-007689-0vpp3xdl	60	25	.	.	.
cord-007689-0vpp3xdl	60	26	1994	1994	CD
cord-007689-0vpp3xdl	60	27	)	)	-RRB-
cord-007689-0vpp3xdl	60	28	.	.	.
cord-007689-0vpp3xdl	61	1	However	however	RB
cord-007689-0vpp3xdl	61	2	,	,	,
cord-007689-0vpp3xdl	61	3	these	these	DT
cord-007689-0vpp3xdl	61	4	findings	finding	NNS
cord-007689-0vpp3xdl	61	5	remained	remain	VBD
cord-007689-0vpp3xdl	61	6	controversial	controversial	JJ
cord-007689-0vpp3xdl	61	7	,	,	,
cord-007689-0vpp3xdl	61	8	as	as	IN
cord-007689-0vpp3xdl	61	9	other	other	JJ
cord-007689-0vpp3xdl	61	10	studies	study	NNS
cord-007689-0vpp3xdl	61	11	that	that	WDT
cord-007689-0vpp3xdl	61	12	examined	examine	VBD
cord-007689-0vpp3xdl	61	13	PKR	PKR	NNP
cord-007689-0vpp3xdl	61	14	-	-	HYPH
cord-007689-0vpp3xdl	61	15	deficient	deficient	JJ
cord-007689-0vpp3xdl	61	16	mice	mouse	NNS
cord-007689-0vpp3xdl	61	17	and	and	CC
cord-007689-0vpp3xdl	61	18	cells	cell	NNS
cord-007689-0vpp3xdl	62	1	(	(	-LRB-
cord-007689-0vpp3xdl	62	2	Chu	Chu	NNP
cord-007689-0vpp3xdl	62	3	et	et	FW
cord-007689-0vpp3xdl	62	4	al	al	NNP
cord-007689-0vpp3xdl	62	5	.	.	.
cord-007689-0vpp3xdl	63	1	1999	1999	CD
cord-007689-0vpp3xdl	63	2	;	;	:
cord-007689-0vpp3xdl	63	3	Iordanov	Iordanov	NNP
cord-007689-0vpp3xdl	63	4	et	et	NNP
cord-007689-0vpp3xdl	63	5	al	al	NNP
cord-007689-0vpp3xdl	63	6	.	.	.
cord-007689-0vpp3xdl	64	1	2001	2001	CD
cord-007689-0vpp3xdl	64	2	;	;	:
cord-007689-0vpp3xdl	64	3	Maggi	Maggi	NNP
cord-007689-0vpp3xdl	64	4	et	et	NNP
cord-007689-0vpp3xdl	64	5	al	al	NNP
cord-007689-0vpp3xdl	64	6	.	.	.
cord-007689-0vpp3xdl	65	1	2000	2000	CD
cord-007689-0vpp3xdl	65	2	;	;	:
cord-007689-0vpp3xdl	65	3	Smith	Smith	NNP
cord-007689-0vpp3xdl	65	4	et	et	NNP
cord-007689-0vpp3xdl	65	5	al	al	NNP
cord-007689-0vpp3xdl	65	6	.	.	.
cord-007689-0vpp3xdl	66	1	2001	2001	CD
cord-007689-0vpp3xdl	66	2	;	;	:
cord-007689-0vpp3xdl	66	3	Yang	Yang	NNP
cord-007689-0vpp3xdl	66	4	et	et	NNP
cord-007689-0vpp3xdl	66	5	al	al	NNP
cord-007689-0vpp3xdl	66	6	.	.	NNP
cord-007689-0vpp3xdl	66	7	1995	1995	CD
cord-007689-0vpp3xdl	66	8	)	)	-RRB-
cord-007689-0vpp3xdl	66	9	found	find	VBD
cord-007689-0vpp3xdl	66	10	no	no	DT
cord-007689-0vpp3xdl	66	11	defects	defect	NNS
cord-007689-0vpp3xdl	66	12	in	in	IN
cord-007689-0vpp3xdl	66	13	the	the	DT
cord-007689-0vpp3xdl	66	14	induction	induction	NN
cord-007689-0vpp3xdl	66	15	of	of	IN
cord-007689-0vpp3xdl	66	16	interferon	interferon	NN
cord-007689-0vpp3xdl	66	17	in	in	IN
cord-007689-0vpp3xdl	66	18	response	response	NN
cord-007689-0vpp3xdl	66	19	to	to	IN
cord-007689-0vpp3xdl	66	20	poly	poly	NNP
cord-007689-0vpp3xdl	66	21	I	I	NNP
cord-007689-0vpp3xdl	66	22	:	:	:
cord-007689-0vpp3xdl	66	23	C	c	NN
cord-007689-0vpp3xdl	66	24	or	or	CC
cord-007689-0vpp3xdl	66	25	viral	viral	JJ
cord-007689-0vpp3xdl	66	26	infection	infection	NN
cord-007689-0vpp3xdl	66	27	that	that	WDT
cord-007689-0vpp3xdl	66	28	could	could	MD
cord-007689-0vpp3xdl	66	29	not	not	RB
cord-007689-0vpp3xdl	66	30	be	be	VB
cord-007689-0vpp3xdl	66	31	overcome	overcome	VBN
cord-007689-0vpp3xdl	66	32	with	with	IN
cord-007689-0vpp3xdl	66	33	type	type	NN
cord-007689-0vpp3xdl	66	34	I	-PRON-	PRP
cord-007689-0vpp3xdl	66	35	IFN	IFN	NNP
cord-007689-0vpp3xdl	66	36	pretreatment	pretreatment	NN
cord-007689-0vpp3xdl	66	37	.	.	.
cord-007689-0vpp3xdl	67	1	Further	further	JJ
cord-007689-0vpp3xdl	67	2	analysis	analysis	NN
cord-007689-0vpp3xdl	67	3	revealed	reveal	VBD
cord-007689-0vpp3xdl	67	4	that	that	IN
cord-007689-0vpp3xdl	67	5	PKR	PKR	NNP
cord-007689-0vpp3xdl	67	6	is	be	VBZ
cord-007689-0vpp3xdl	67	7	not	not	RB
cord-007689-0vpp3xdl	67	8	only	only	RB
cord-007689-0vpp3xdl	67	9	activated	activate	VBN
cord-007689-0vpp3xdl	67	10	by	by	IN
cord-007689-0vpp3xdl	67	11	poly	poly	NNP
cord-007689-0vpp3xdl	67	12	I	I	NNP
cord-007689-0vpp3xdl	67	13	:	:	:
cord-007689-0vpp3xdl	67	14	C	c	NN
cord-007689-0vpp3xdl	67	15	but	but	CC
cord-007689-0vpp3xdl	67	16	is	be	VBZ
cord-007689-0vpp3xdl	67	17	able	able	JJ
cord-007689-0vpp3xdl	67	18	to	to	TO
cord-007689-0vpp3xdl	67	19	interact	interact	VB
cord-007689-0vpp3xdl	67	20	with	with	IN
cord-007689-0vpp3xdl	67	21	dsRNA	dsRNA	NNS
cord-007689-0vpp3xdl	67	22	as	as	RB
cord-007689-0vpp3xdl	67	23	short	short	JJ
cord-007689-0vpp3xdl	67	24	as	as	IN
cord-007689-0vpp3xdl	67	25	11	11	CD
cord-007689-0vpp3xdl	67	26	bp	bp	NNP
cord-007689-0vpp3xdl	67	27	.	.	.
cord-007689-0vpp3xdl	68	1	However	however	RB
cord-007689-0vpp3xdl	68	2	,	,	,
cord-007689-0vpp3xdl	68	3	at	at	RB
cord-007689-0vpp3xdl	68	4	least	least	RBS
cord-007689-0vpp3xdl	68	5	30	30	CD
cord-007689-0vpp3xdl	68	6	bp	bp	NNS
cord-007689-0vpp3xdl	68	7	are	be	VBP
cord-007689-0vpp3xdl	68	8	required	require	VBN
cord-007689-0vpp3xdl	68	9	to	to	TO
cord-007689-0vpp3xdl	68	10	activate	activate	VB
cord-007689-0vpp3xdl	68	11	PKR	PKR	NNP
cord-007689-0vpp3xdl	68	12	kinase	kinase	NN
cord-007689-0vpp3xdl	68	13	activity	activity	NN
cord-007689-0vpp3xdl	68	14	(	(	-LRB-
cord-007689-0vpp3xdl	68	15	Manche	Manche	NNP
cord-007689-0vpp3xdl	68	16	et	et	FW
cord-007689-0vpp3xdl	68	17	al	al	NNP
cord-007689-0vpp3xdl	68	18	.	.	NNP
cord-007689-0vpp3xdl	68	19	1992	1992	CD
cord-007689-0vpp3xdl	68	20	)	)	-RRB-
cord-007689-0vpp3xdl	68	21	.	.	.
cord-007689-0vpp3xdl	69	1	In	in	IN
cord-007689-0vpp3xdl	69	2	another	another	DT
cord-007689-0vpp3xdl	69	3	study	study	NN
cord-007689-0vpp3xdl	69	4	(	(	-LRB-
cord-007689-0vpp3xdl	69	5	Zheng	Zheng	NNP
cord-007689-0vpp3xdl	69	6	and	and	CC
cord-007689-0vpp3xdl	69	7	Bevilacqua	Bevilacqua	NNP
cord-007689-0vpp3xdl	69	8	2004	2004	CD
cord-007689-0vpp3xdl	69	9	)	)	-RRB-
cord-007689-0vpp3xdl	69	10	,	,	,
cord-007689-0vpp3xdl	69	11	recombinant	recombinant	JJ
cord-007689-0vpp3xdl	69	12	PKR	PKR	NNP
cord-007689-0vpp3xdl	69	13	could	could	MD
cord-007689-0vpp3xdl	69	14	also	also	RB
cord-007689-0vpp3xdl	69	15	be	be	VB
cord-007689-0vpp3xdl	69	16	activated	activate	VBN
cord-007689-0vpp3xdl	69	17	by	by	IN
cord-007689-0vpp3xdl	69	18	RNA	RNA	NNP
cord-007689-0vpp3xdl	69	19	oligonucleotides	oligonucleotide	NNS
cord-007689-0vpp3xdl	69	20	containing	contain	VBG
cord-007689-0vpp3xdl	69	21	a	a	DT
cord-007689-0vpp3xdl	69	22	16-bp	16-bp	CD
cord-007689-0vpp3xdl	69	23	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	69	24	stem	stem	NN
cord-007689-0vpp3xdl	69	25	loop	loop	NN
cord-007689-0vpp3xdl	69	26	in	in	IN
cord-007689-0vpp3xdl	69	27	combination	combination	NN
cord-007689-0vpp3xdl	69	28	with	with	IN
cord-007689-0vpp3xdl	69	29	a	a	DT
cord-007689-0vpp3xdl	69	30	more	more	JJR
cord-007689-0vpp3xdl	69	31	than	than	IN
cord-007689-0vpp3xdl	69	32	11bp	11bp	JJ
cord-007689-0vpp3xdl	69	33	-	-	HYPH
cord-007689-0vpp3xdl	69	34	long	long	JJ
cord-007689-0vpp3xdl	69	35	single	single	RB
cord-007689-0vpp3xdl	69	36	-	-	HYPH
cord-007689-0vpp3xdl	69	37	stranded	strand	VBN
cord-007689-0vpp3xdl	69	38	RNA	RNA	NNP
cord-007689-0vpp3xdl	69	39	part	part	NN
cord-007689-0vpp3xdl	69	40	at	at	IN
cord-007689-0vpp3xdl	69	41	the	the	DT
cord-007689-0vpp3xdl	69	42	5′	5′	CD
cord-007689-0vpp3xdl	69	43	or	or	CC
cord-007689-0vpp3xdl	69	44	3′	3′	CD
cord-007689-0vpp3xdl	69	45	end	end	NN
cord-007689-0vpp3xdl	69	46	.	.	.
cord-007689-0vpp3xdl	70	1	All	all	PDT
cord-007689-0vpp3xdl	70	2	these	these	DT
cord-007689-0vpp3xdl	70	3	studies	study	NNS
cord-007689-0vpp3xdl	70	4	question	question	VBP
cord-007689-0vpp3xdl	70	5	the	the	DT
cord-007689-0vpp3xdl	70	6	often	often	RB
cord-007689-0vpp3xdl	70	7	quoted	quote	VBN
cord-007689-0vpp3xdl	70	8	requirement	requirement	NN
cord-007689-0vpp3xdl	70	9	of	of	IN
cord-007689-0vpp3xdl	70	10	a	a	DT
cord-007689-0vpp3xdl	70	11	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	70	12	molecule	molecule	NN
cord-007689-0vpp3xdl	70	13	longer	long	JJR
cord-007689-0vpp3xdl	70	14	than	than	IN
cord-007689-0vpp3xdl	70	15	30	30	CD
cord-007689-0vpp3xdl	70	16	bp	bp	NN
cord-007689-0vpp3xdl	70	17	;	;	:
cord-007689-0vpp3xdl	70	18	furthermore	furthermore	RB
cord-007689-0vpp3xdl	70	19	,	,	,
cord-007689-0vpp3xdl	70	20	it	-PRON-	PRP
cord-007689-0vpp3xdl	70	21	became	become	VBD
cord-007689-0vpp3xdl	70	22	evident	evident	JJ
cord-007689-0vpp3xdl	70	23	that	that	IN
cord-007689-0vpp3xdl	70	24	the	the	DT
cord-007689-0vpp3xdl	70	25	translational	translational	JJ
cord-007689-0vpp3xdl	70	26	shut	shut	NN
cord-007689-0vpp3xdl	70	27	-	-	HYPH
cord-007689-0vpp3xdl	70	28	down	down	NN
cord-007689-0vpp3xdl	70	29	by	by	IN
cord-007689-0vpp3xdl	70	30	PKR	PKR	NNP
cord-007689-0vpp3xdl	70	31	is	be	VBZ
cord-007689-0vpp3xdl	70	32	not	not	RB
cord-007689-0vpp3xdl	70	33	linked	link	VBN
cord-007689-0vpp3xdl	70	34	to	to	IN
cord-007689-0vpp3xdl	70	35	the	the	DT
cord-007689-0vpp3xdl	70	36	induction	induction	NN
cord-007689-0vpp3xdl	70	37	of	of	IN
cord-007689-0vpp3xdl	70	38	type	type	NN
cord-007689-0vpp3xdl	71	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	71	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	71	3	synthesis	synthesis	NN
cord-007689-0vpp3xdl	71	4	and	and	CC
cord-007689-0vpp3xdl	71	5	secretion	secretion	NN
cord-007689-0vpp3xdl	71	6	.	.	.
cord-007689-0vpp3xdl	72	1	The	the	DT
cord-007689-0vpp3xdl	72	2	finding	finding	NN
cord-007689-0vpp3xdl	72	3	that	that	IN
cord-007689-0vpp3xdl	72	4	PKR	PKR	NNP
cord-007689-0vpp3xdl	72	5	-/cells	-/cells	NNP
cord-007689-0vpp3xdl	72	6	still	still	RB
cord-007689-0vpp3xdl	72	7	produce	produce	VBP
cord-007689-0vpp3xdl	72	8	type	type	NN
cord-007689-0vpp3xdl	72	9	I	-PRON-	PRP
cord-007689-0vpp3xdl	72	10	IFNs	ifns	VBP
cord-007689-0vpp3xdl	72	11	spurred	spur	VBD
cord-007689-0vpp3xdl	72	12	further	further	JJ
cord-007689-0vpp3xdl	72	13	research	research	NN
cord-007689-0vpp3xdl	72	14	on	on	IN
cord-007689-0vpp3xdl	72	15	receptors	receptor	NNS
cord-007689-0vpp3xdl	72	16	capable	capable	JJ
cord-007689-0vpp3xdl	72	17	of	of	IN
cord-007689-0vpp3xdl	72	18	recognizing	recognize	VBG
cord-007689-0vpp3xdl	72	19	long	long	JJ
cord-007689-0vpp3xdl	72	20	double	double	RB
cord-007689-0vpp3xdl	72	21	-	-	HYPH
cord-007689-0vpp3xdl	72	22	stranded	strand	VBN
cord-007689-0vpp3xdl	72	23	RNA	RNA	NNP
cord-007689-0vpp3xdl	72	24	.	.	.
cord-007689-0vpp3xdl	73	1	Such	such	JJ
cord-007689-0vpp3xdl	73	2	investigations	investigation	NNS
cord-007689-0vpp3xdl	73	3	led	lead	VBD
cord-007689-0vpp3xdl	73	4	to	to	IN
cord-007689-0vpp3xdl	73	5	a	a	DT
cord-007689-0vpp3xdl	73	6	member	member	NN
cord-007689-0vpp3xdl	73	7	of	of	IN
cord-007689-0vpp3xdl	73	8	the	the	DT
cord-007689-0vpp3xdl	73	9	Toll	Toll	NNP
cord-007689-0vpp3xdl	73	10	-	-	HYPH
cord-007689-0vpp3xdl	73	11	like	like	JJ
cord-007689-0vpp3xdl	73	12	receptor	receptor	NN
cord-007689-0vpp3xdl	73	13	(	(	-LRB-
cord-007689-0vpp3xdl	73	14	TLR	TLR	NNP
cord-007689-0vpp3xdl	73	15	)	)	-RRB-
cord-007689-0vpp3xdl	73	16	family	family	NN
cord-007689-0vpp3xdl	73	17	,	,	,
cord-007689-0vpp3xdl	73	18	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	73	19	,	,	,
cord-007689-0vpp3xdl	73	20	which	which	WDT
cord-007689-0vpp3xdl	73	21	was	be	VBD
cord-007689-0vpp3xdl	73	22	proposed	propose	VBN
cord-007689-0vpp3xdl	73	23	to	to	TO
cord-007689-0vpp3xdl	73	24	bind	bind	VB
cord-007689-0vpp3xdl	73	25	to	to	IN
cord-007689-0vpp3xdl	73	26	long	long	JJ
cord-007689-0vpp3xdl	73	27	dsRNA	dsRNA	NNS
cord-007689-0vpp3xdl	73	28	and	and	CC
cord-007689-0vpp3xdl	73	29	to	to	TO
cord-007689-0vpp3xdl	73	30	induce	induce	VB
cord-007689-0vpp3xdl	73	31	IFN	IFN	NNP
cord-007689-0vpp3xdl	73	32	-	-	HYPH
cord-007689-0vpp3xdl	73	33	β	β	NNP
cord-007689-0vpp3xdl	73	34	(	(	-LRB-
cord-007689-0vpp3xdl	73	35	Alexopoulou	Alexopoulou	NNP
cord-007689-0vpp3xdl	73	36	et	et	NNP
cord-007689-0vpp3xdl	73	37	al	al	NNP
cord-007689-0vpp3xdl	73	38	.	.	NNP
cord-007689-0vpp3xdl	73	39	2001	2001	CD
cord-007689-0vpp3xdl	73	40	)	)	-RRB-
cord-007689-0vpp3xdl	73	41	.	.	.
cord-007689-0vpp3xdl	74	1	TLRs	TLRs	NNP
cord-007689-0vpp3xdl	74	2	are	be	VBP
cord-007689-0vpp3xdl	74	3	transmembrane	transmembrane	NN
cord-007689-0vpp3xdl	74	4	receptors	receptor	NNS
cord-007689-0vpp3xdl	74	5	that	that	WDT
cord-007689-0vpp3xdl	74	6	were	be	VBD
cord-007689-0vpp3xdl	74	7	shown	show	VBN
cord-007689-0vpp3xdl	74	8	to	to	TO
cord-007689-0vpp3xdl	74	9	recognize	recognize	VB
cord-007689-0vpp3xdl	74	10	a	a	DT
cord-007689-0vpp3xdl	74	11	variety	variety	NN
cord-007689-0vpp3xdl	74	12	of	of	IN
cord-007689-0vpp3xdl	74	13	conserved	conserve	VBN
cord-007689-0vpp3xdl	74	14	pathogenassociated	pathogenassociate	VBN
cord-007689-0vpp3xdl	74	15	molecular	molecular	JJ
cord-007689-0vpp3xdl	74	16	patterns	pattern	NNS
cord-007689-0vpp3xdl	74	17	(	(	-LRB-
cord-007689-0vpp3xdl	74	18	PAMPs	pamp	NNS
cord-007689-0vpp3xdl	74	19	)	)	-RRB-
cord-007689-0vpp3xdl	74	20	of	of	IN
cord-007689-0vpp3xdl	74	21	bacterial	bacterial	JJ
cord-007689-0vpp3xdl	74	22	,	,	,
cord-007689-0vpp3xdl	74	23	fungal	fungal	JJ
cord-007689-0vpp3xdl	74	24	,	,	,
cord-007689-0vpp3xdl	74	25	and	and	CC
cord-007689-0vpp3xdl	74	26	parasitic	parasitic	JJ
cord-007689-0vpp3xdl	74	27	origin	origin	NN
cord-007689-0vpp3xdl	74	28	.	.	.
cord-007689-0vpp3xdl	75	1	The	the	DT
cord-007689-0vpp3xdl	75	2	study	study	NN
cord-007689-0vpp3xdl	75	3	of	of	IN
cord-007689-0vpp3xdl	75	4	Alexopoulou	Alexopoulou	NNP
cord-007689-0vpp3xdl	75	5	et	et	NNP
cord-007689-0vpp3xdl	75	6	al	al	NNP
cord-007689-0vpp3xdl	75	7	.	.	NNP
cord-007689-0vpp3xdl	75	8	was	be	VBD
cord-007689-0vpp3xdl	75	9	the	the	DT
cord-007689-0vpp3xdl	75	10	first	first	JJ
cord-007689-0vpp3xdl	75	11	to	to	TO
cord-007689-0vpp3xdl	75	12	demonstrate	demonstrate	VB
cord-007689-0vpp3xdl	75	13	a	a	DT
cord-007689-0vpp3xdl	75	14	role	role	NN
cord-007689-0vpp3xdl	75	15	for	for	IN
cord-007689-0vpp3xdl	75	16	TLRs	tlr	NNS
cord-007689-0vpp3xdl	75	17	in	in	IN
cord-007689-0vpp3xdl	75	18	the	the	DT
cord-007689-0vpp3xdl	75	19	recognition	recognition	NN
cord-007689-0vpp3xdl	75	20	of	of	IN
cord-007689-0vpp3xdl	75	21	viruses	virus	NNS
cord-007689-0vpp3xdl	75	22	.	.	.
cord-007689-0vpp3xdl	76	1	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	76	2	was	be	VBD
cord-007689-0vpp3xdl	76	3	found	find	VBN
cord-007689-0vpp3xdl	76	4	to	to	TO
cord-007689-0vpp3xdl	76	5	be	be	VB
cord-007689-0vpp3xdl	76	6	the	the	DT
cord-007689-0vpp3xdl	76	7	receptor	receptor	NN
cord-007689-0vpp3xdl	76	8	for	for	IN
cord-007689-0vpp3xdl	76	9	unmethylated	unmethylate	VBN
cord-007689-0vpp3xdl	76	10	CpG	CpG	NNP
cord-007689-0vpp3xdl	76	11	motifs	motif	NNS
cord-007689-0vpp3xdl	76	12	in	in	IN
cord-007689-0vpp3xdl	76	13	DNA	DNA	NNP
cord-007689-0vpp3xdl	76	14	(	(	-LRB-
cord-007689-0vpp3xdl	76	15	Hemmi	Hemmi	NNP
cord-007689-0vpp3xdl	76	16	et	et	NNP
cord-007689-0vpp3xdl	76	17	al	al	NNP
cord-007689-0vpp3xdl	76	18	2000	2000	CD
cord-007689-0vpp3xdl	76	19	)	)	-RRB-
cord-007689-0vpp3xdl	76	20	;	;	:
cord-007689-0vpp3xdl	76	21	however	however	RB
cord-007689-0vpp3xdl	76	22	,	,	,
cord-007689-0vpp3xdl	76	23	CpG	CpG	NNP
cord-007689-0vpp3xdl	76	24	-	-	HYPH
cord-007689-0vpp3xdl	76	25	DNA	DNA	NNP
cord-007689-0vpp3xdl	76	26	at	at	IN
cord-007689-0vpp3xdl	76	27	first	first	RB
cord-007689-0vpp3xdl	76	28	was	be	VBD
cord-007689-0vpp3xdl	76	29	thought	think	VBN
cord-007689-0vpp3xdl	76	30	to	to	TO
cord-007689-0vpp3xdl	76	31	be	be	VB
cord-007689-0vpp3xdl	76	32	characteristic	characteristic	JJ
cord-007689-0vpp3xdl	76	33	for	for	IN
cord-007689-0vpp3xdl	76	34	bacterial	bacterial	JJ
cord-007689-0vpp3xdl	76	35	DNA	dna	NN
cord-007689-0vpp3xdl	76	36	,	,	,
cord-007689-0vpp3xdl	76	37	and	and	CC
cord-007689-0vpp3xdl	76	38	the	the	DT
cord-007689-0vpp3xdl	76	39	role	role	NN
cord-007689-0vpp3xdl	76	40	of	of	IN
cord-007689-0vpp3xdl	76	41	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	76	42	in	in	IN
cord-007689-0vpp3xdl	76	43	detecting	detect	VBG
cord-007689-0vpp3xdl	76	44	DNA	dna	NN
cord-007689-0vpp3xdl	76	45	viruses	virus	NNS
cord-007689-0vpp3xdl	76	46	was	be	VBD
cord-007689-0vpp3xdl	76	47	only	only	RB
cord-007689-0vpp3xdl	76	48	proposed	propose	VBN
cord-007689-0vpp3xdl	76	49	later	later	RB
cord-007689-0vpp3xdl	77	1	(	(	-LRB-
cord-007689-0vpp3xdl	77	2	Krug	Krug	NNP
cord-007689-0vpp3xdl	77	3	et	et	NNP
cord-007689-0vpp3xdl	77	4	al	al	NNP
cord-007689-0vpp3xdl	77	5	.	.	.
cord-007689-0vpp3xdl	78	1	2004a	2004a	CD
cord-007689-0vpp3xdl	79	1	(	(	-LRB-
cord-007689-0vpp3xdl	79	2	Krug	Krug	NNP
cord-007689-0vpp3xdl	79	3	et	et	NNP
cord-007689-0vpp3xdl	79	4	al	al	NNP
cord-007689-0vpp3xdl	79	5	.	.	.
cord-007689-0vpp3xdl	80	1	,	,	,
cord-007689-0vpp3xdl	80	2	2004b	2004b	CD
cord-007689-0vpp3xdl	80	3	Tabeta	Tabeta	NNP
cord-007689-0vpp3xdl	80	4	et	et	FW
cord-007689-0vpp3xdl	80	5	al	al	NNP
cord-007689-0vpp3xdl	80	6	.	.	.
cord-007689-0vpp3xdl	80	7	2004	2004	CD
cord-007689-0vpp3xdl	80	8	)	)	-RRB-
cord-007689-0vpp3xdl	80	9	.	.	.
cord-007689-0vpp3xdl	81	1	Upon	upon	IN
cord-007689-0vpp3xdl	81	2	engagement	engagement	NN
cord-007689-0vpp3xdl	81	3	with	with	IN
cord-007689-0vpp3xdl	81	4	their	-PRON-	PRP$
cord-007689-0vpp3xdl	81	5	specific	specific	JJ
cord-007689-0vpp3xdl	81	6	ligands	ligand	NNS
cord-007689-0vpp3xdl	81	7	,	,	,
cord-007689-0vpp3xdl	81	8	TLRs	TLRs	NNP
cord-007689-0vpp3xdl	81	9	trigger	trigger	NN
cord-007689-0vpp3xdl	81	10	signaling	signal	VBG
cord-007689-0vpp3xdl	81	11	pathways	pathway	NNS
cord-007689-0vpp3xdl	81	12	that	that	WDT
cord-007689-0vpp3xdl	81	13	lead	lead	VBP
cord-007689-0vpp3xdl	81	14	to	to	IN
cord-007689-0vpp3xdl	81	15	the	the	DT
cord-007689-0vpp3xdl	81	16	activation	activation	NN
cord-007689-0vpp3xdl	81	17	of	of	IN
cord-007689-0vpp3xdl	81	18	NF	nf	NN
cord-007689-0vpp3xdl	81	19	-	-	HYPH
cord-007689-0vpp3xdl	81	20	κB	κB	NNP
cord-007689-0vpp3xdl	81	21	and	and	CC
cord-007689-0vpp3xdl	81	22	IRFs	IRFs	NNP
cord-007689-0vpp3xdl	81	23	(	(	-LRB-
cord-007689-0vpp3xdl	81	24	signaling	signal	VBG
cord-007689-0vpp3xdl	81	25	of	of	IN
cord-007689-0vpp3xdl	81	26	TLRs	tlr	NNS
cord-007689-0vpp3xdl	81	27	reviewed	review	VBN
cord-007689-0vpp3xdl	81	28	in	in	IN
cord-007689-0vpp3xdl	81	29	Moynagh	Moynagh	NNP
cord-007689-0vpp3xdl	81	30	2005	2005	CD
cord-007689-0vpp3xdl	81	31	)	)	-RRB-
cord-007689-0vpp3xdl	81	32	.	.	.
cord-007689-0vpp3xdl	82	1	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	82	2	was	be	VBD
cord-007689-0vpp3xdl	82	3	found	find	VBN
cord-007689-0vpp3xdl	82	4	to	to	TO
cord-007689-0vpp3xdl	82	5	induce	induce	VB
cord-007689-0vpp3xdl	82	6	type	type	NN
cord-007689-0vpp3xdl	82	7	I	-PRON-	PRP
cord-007689-0vpp3xdl	82	8	IFNs	ifns	VBP
cord-007689-0vpp3xdl	82	9	upon	upon	IN
cord-007689-0vpp3xdl	82	10	poly	poly	NNP
cord-007689-0vpp3xdl	83	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	83	2	:	:	:
cord-007689-0vpp3xdl	83	3	C	c	NN
cord-007689-0vpp3xdl	83	4	stimulation	stimulation	NN
cord-007689-0vpp3xdl	83	5	by	by	IN
cord-007689-0vpp3xdl	83	6	activation	activation	NN
cord-007689-0vpp3xdl	83	7	of	of	IN
cord-007689-0vpp3xdl	83	8	the	the	DT
cord-007689-0vpp3xdl	83	9	kinase	kinase	NN
cord-007689-0vpp3xdl	83	10	TBK1	TBK1	NNP
cord-007689-0vpp3xdl	83	11	,	,	,
cord-007689-0vpp3xdl	83	12	which	which	WDT
cord-007689-0vpp3xdl	83	13	phosphorylates	phosphorylate	VBZ
cord-007689-0vpp3xdl	83	14	the	the	DT
cord-007689-0vpp3xdl	83	15	transcription	transcription	NN
cord-007689-0vpp3xdl	83	16	factor	factor	NN
cord-007689-0vpp3xdl	83	17	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	83	18	,	,	,
cord-007689-0vpp3xdl	83	19	resulting	result	VBG
cord-007689-0vpp3xdl	83	20	in	in	IN
cord-007689-0vpp3xdl	83	21	the	the	DT
cord-007689-0vpp3xdl	83	22	induction	induction	NN
cord-007689-0vpp3xdl	83	23	of	of	IN
cord-007689-0vpp3xdl	83	24	IFN	IFN	NNP
cord-007689-0vpp3xdl	83	25	-	-	HYPH
cord-007689-0vpp3xdl	83	26	β	β	NNP
cord-007689-0vpp3xdl	83	27	(	(	-LRB-
cord-007689-0vpp3xdl	83	28	Doyle	Doyle	NNP
cord-007689-0vpp3xdl	83	29	et	et	NNP
cord-007689-0vpp3xdl	83	30	al	al	NNP
cord-007689-0vpp3xdl	83	31	.	.	.
cord-007689-0vpp3xdl	83	32	2002	2002	CD
cord-007689-0vpp3xdl	83	33	;	;	:
cord-007689-0vpp3xdl	83	34	Fitzgerald	Fitzgerald	NNP
cord-007689-0vpp3xdl	83	35	et	et	NNP
cord-007689-0vpp3xdl	83	36	al	al	NNP
cord-007689-0vpp3xdl	83	37	.	.	.
cord-007689-0vpp3xdl	84	1	2003	2003	CD
cord-007689-0vpp3xdl	84	2	;	;	:
cord-007689-0vpp3xdl	84	3	Sharma	Sharma	NNP
cord-007689-0vpp3xdl	84	4	et	et	NNP
cord-007689-0vpp3xdl	84	5	al	al	NNP
cord-007689-0vpp3xdl	84	6	.	.	NNP
cord-007689-0vpp3xdl	84	7	2003	2003	CD
cord-007689-0vpp3xdl	84	8	)	)	-RRB-
cord-007689-0vpp3xdl	84	9	.	.	.
cord-007689-0vpp3xdl	85	1	Another	another	DT
cord-007689-0vpp3xdl	85	2	group	group	NN
cord-007689-0vpp3xdl	85	3	reported	report	VBD
cord-007689-0vpp3xdl	85	4	that	that	IN
cord-007689-0vpp3xdl	85	5	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	85	6	is	be	VBZ
cord-007689-0vpp3xdl	85	7	activated	activate	VBN
cord-007689-0vpp3xdl	85	8	by	by	IN
cord-007689-0vpp3xdl	85	9	ssRNA	ssRNA	''
cord-007689-0vpp3xdl	86	1	(	(	-LRB-
cord-007689-0vpp3xdl	86	2	Kariko	Kariko	NNP
cord-007689-0vpp3xdl	86	3	et	et	FW
cord-007689-0vpp3xdl	86	4	al	al	NNP
cord-007689-0vpp3xdl	86	5	.	.	NNP
cord-007689-0vpp3xdl	86	6	2004b	2004b	CD
cord-007689-0vpp3xdl	86	7	)	)	-RRB-
cord-007689-0vpp3xdl	86	8	;	;	:
cord-007689-0vpp3xdl	86	9	however	however	RB
cord-007689-0vpp3xdl	86	10	,	,	,
cord-007689-0vpp3xdl	86	11	TLR3-deficient	tlr3-deficient	NN
cord-007689-0vpp3xdl	86	12	mice	mouse	NNS
cord-007689-0vpp3xdl	86	13	and	and	CC
cord-007689-0vpp3xdl	86	14	mice	mouse	NNS
cord-007689-0vpp3xdl	86	15	deficient	deficient	JJ
cord-007689-0vpp3xdl	86	16	in	in	IN
cord-007689-0vpp3xdl	86	17	the	the	DT
cord-007689-0vpp3xdl	86	18	signaling	signal	VBG
cord-007689-0vpp3xdl	86	19	adapter	adapter	NN
cord-007689-0vpp3xdl	86	20	TRIF	TRIF	NNP
cord-007689-0vpp3xdl	87	1	(	(	-LRB-
cord-007689-0vpp3xdl	87	2	Gitlin	Gitlin	NNP
cord-007689-0vpp3xdl	87	3	et	et	FW
cord-007689-0vpp3xdl	87	4	al	al	NNP
cord-007689-0vpp3xdl	87	5	.	.	.
cord-007689-0vpp3xdl	88	1	2006	2006	CD
cord-007689-0vpp3xdl	88	2	;	;	:
cord-007689-0vpp3xdl	88	3	Kato	Kato	NNP
cord-007689-0vpp3xdl	88	4	et	et	NNP
cord-007689-0vpp3xdl	88	5	al	al	NNP
cord-007689-0vpp3xdl	88	6	.	.	.
cord-007689-0vpp3xdl	89	1	2006	2006	CD
cord-007689-0vpp3xdl	89	2	)	)	-RRB-
cord-007689-0vpp3xdl	89	3	still	still	RB
cord-007689-0vpp3xdl	89	4	responded	respond	VBD
cord-007689-0vpp3xdl	89	5	to	to	IN
cord-007689-0vpp3xdl	89	6	poly	poly	NNP
cord-007689-0vpp3xdl	89	7	I	I	NNP
cord-007689-0vpp3xdl	89	8	:	:	:
cord-007689-0vpp3xdl	90	1	C.	C.	NNP
cord-007689-0vpp3xdl	90	2	Moreover	Moreover	NNP
cord-007689-0vpp3xdl	90	3	,	,	,
cord-007689-0vpp3xdl	90	4	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	90	5	cells	cell	NNS
cord-007689-0vpp3xdl	90	6	derived	derive	VBN
cord-007689-0vpp3xdl	90	7	from	from	IN
cord-007689-0vpp3xdl	90	8	TLR3-deficient	tlr3-deficient	NN
cord-007689-0vpp3xdl	90	9	mice	mouse	NNS
cord-007689-0vpp3xdl	90	10	were	be	VBD
cord-007689-0vpp3xdl	90	11	still	still	RB
cord-007689-0vpp3xdl	90	12	stimulated	stimulate	VBN
cord-007689-0vpp3xdl	90	13	by	by	IN
cord-007689-0vpp3xdl	90	14	dsRNA	dsRNA	VBG
cord-007689-0vpp3xdl	90	15	transfected	transfecte	VBN
cord-007689-0vpp3xdl	90	16	into	into	IN
cord-007689-0vpp3xdl	90	17	the	the	DT
cord-007689-0vpp3xdl	90	18	cytosol	cytosol	NN
cord-007689-0vpp3xdl	90	19	(	(	-LRB-
cord-007689-0vpp3xdl	90	20	Diebold	Diebold	NNP
cord-007689-0vpp3xdl	90	21	et	et	FW
cord-007689-0vpp3xdl	90	22	al	al	NNP
cord-007689-0vpp3xdl	90	23	.	.	NNP
cord-007689-0vpp3xdl	90	24	2003	2003	CD
cord-007689-0vpp3xdl	90	25	)	)	-RRB-
cord-007689-0vpp3xdl	90	26	.	.	.
cord-007689-0vpp3xdl	91	1	Unlike	unlike	IN
cord-007689-0vpp3xdl	91	2	tumor	tumor	NN
cord-007689-0vpp3xdl	91	3	cell	cell	NN
cord-007689-0vpp3xdl	91	4	lines	line	NNS
cord-007689-0vpp3xdl	91	5	,	,	,
cord-007689-0vpp3xdl	91	6	which	which	WDT
cord-007689-0vpp3xdl	91	7	were	be	VBD
cord-007689-0vpp3xdl	91	8	examined	examine	VBN
cord-007689-0vpp3xdl	91	9	in	in	IN
cord-007689-0vpp3xdl	91	10	early	early	JJ
cord-007689-0vpp3xdl	91	11	studies	study	NNS
cord-007689-0vpp3xdl	91	12	on	on	IN
cord-007689-0vpp3xdl	91	13	type	type	NN
cord-007689-0vpp3xdl	92	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	92	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	92	3	and	and	CC
cord-007689-0vpp3xdl	92	4	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	92	5	,	,	,
cord-007689-0vpp3xdl	92	6	primary	primary	JJ
cord-007689-0vpp3xdl	92	7	immune	immune	JJ
cord-007689-0vpp3xdl	92	8	cells	cell	NNS
cord-007689-0vpp3xdl	92	9	such	such	JJ
cord-007689-0vpp3xdl	92	10	as	as	IN
cord-007689-0vpp3xdl	92	11	peripheral	peripheral	JJ
cord-007689-0vpp3xdl	92	12	blood	blood	NN
cord-007689-0vpp3xdl	92	13	mononuclear	mononuclear	NN
cord-007689-0vpp3xdl	92	14	cells	cell	NNS
cord-007689-0vpp3xdl	92	15	(	(	-LRB-
cord-007689-0vpp3xdl	92	16	PBMCs	PBMCs	NNP
cord-007689-0vpp3xdl	92	17	)	)	-RRB-
cord-007689-0vpp3xdl	92	18	express	express	VB
cord-007689-0vpp3xdl	92	19	a	a	DT
cord-007689-0vpp3xdl	92	20	wide	wide	JJ
cord-007689-0vpp3xdl	92	21	spectrum	spectrum	NN
cord-007689-0vpp3xdl	92	22	of	of	IN
cord-007689-0vpp3xdl	92	23	functional	functional	JJ
cord-007689-0vpp3xdl	92	24	TLRs	tlr	NNS
cord-007689-0vpp3xdl	92	25	.	.	.
cord-007689-0vpp3xdl	93	1	Different	different	JJ
cord-007689-0vpp3xdl	93	2	immune	immune	JJ
cord-007689-0vpp3xdl	93	3	cell	cell	NN
cord-007689-0vpp3xdl	93	4	subsets	subset	NNS
cord-007689-0vpp3xdl	93	5	express	express	VBP
cord-007689-0vpp3xdl	93	6	distinct	distinct	JJ
cord-007689-0vpp3xdl	93	7	patterns	pattern	NNS
cord-007689-0vpp3xdl	93	8	of	of	IN
cord-007689-0vpp3xdl	93	9	TLRs	tlr	NNS
cord-007689-0vpp3xdl	93	10	(	(	-LRB-
cord-007689-0vpp3xdl	93	11	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	93	12	et	et	NNP
cord-007689-0vpp3xdl	93	13	al	al	NNP
cord-007689-0vpp3xdl	93	14	.	.	.
cord-007689-0vpp3xdl	93	15	2002	2002	CD
cord-007689-0vpp3xdl	93	16	)	)	-RRB-
cord-007689-0vpp3xdl	93	17	.	.	.
cord-007689-0vpp3xdl	94	1	Plasmacytoid	Plasmacytoid	NNP
cord-007689-0vpp3xdl	94	2	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	94	3	cells	cell	NNS
cord-007689-0vpp3xdl	94	4	(	(	-LRB-
cord-007689-0vpp3xdl	94	5	PDCs	pdc	NNS
cord-007689-0vpp3xdl	94	6	)	)	-RRB-
cord-007689-0vpp3xdl	94	7	(	(	-LRB-
cord-007689-0vpp3xdl	94	8	reviewed	review	VBN
cord-007689-0vpp3xdl	94	9	in	in	IN
cord-007689-0vpp3xdl	94	10	Colonna	Colonna	NNP
cord-007689-0vpp3xdl	94	11	et	et	FW
cord-007689-0vpp3xdl	94	12	al	al	NNP
cord-007689-0vpp3xdl	94	13	.	.	.
cord-007689-0vpp3xdl	94	14	2004	2004	CD
cord-007689-0vpp3xdl	94	15	)	)	-RRB-
cord-007689-0vpp3xdl	94	16	are	be	VBP
cord-007689-0vpp3xdl	94	17	the	the	DT
cord-007689-0vpp3xdl	94	18	major	major	JJ
cord-007689-0vpp3xdl	94	19	producers	producer	NNS
cord-007689-0vpp3xdl	94	20	of	of	IN
cord-007689-0vpp3xdl	94	21	early	early	JJ
cord-007689-0vpp3xdl	94	22	type	type	NN
cord-007689-0vpp3xdl	95	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	95	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	95	3	production	production	NN
cord-007689-0vpp3xdl	95	4	upon	upon	IN
cord-007689-0vpp3xdl	95	5	viral	viral	JJ
cord-007689-0vpp3xdl	95	6	infection	infection	NN
cord-007689-0vpp3xdl	95	7	.	.	.
cord-007689-0vpp3xdl	96	1	PDCs	pdc	NNS
cord-007689-0vpp3xdl	96	2	express	express	VBP
cord-007689-0vpp3xdl	96	3	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	96	4	and	and	CC
cord-007689-0vpp3xdl	96	5	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	96	6	but	but	CC
cord-007689-0vpp3xdl	96	7	not	not	RB
cord-007689-0vpp3xdl	96	8	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	96	9	.	.	.
cord-007689-0vpp3xdl	97	1	Both	both	DT
cord-007689-0vpp3xdl	97	2	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	97	3	and	and	CC
cord-007689-0vpp3xdl	97	4	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	97	5	are	be	VBP
cord-007689-0vpp3xdl	97	6	located	locate	VBN
cord-007689-0vpp3xdl	97	7	in	in	IN
cord-007689-0vpp3xdl	97	8	the	the	DT
cord-007689-0vpp3xdl	97	9	endosomal	endosomal	NNP
cord-007689-0vpp3xdl	97	10	compartment	compartment	NN
cord-007689-0vpp3xdl	97	11	and	and	CC
cord-007689-0vpp3xdl	97	12	signal	signal	VB
cord-007689-0vpp3xdl	97	13	via	via	IN
cord-007689-0vpp3xdl	97	14	the	the	DT
cord-007689-0vpp3xdl	97	15	adaptor	adaptor	NN
cord-007689-0vpp3xdl	97	16	molecules	molecule	NNS
cord-007689-0vpp3xdl	97	17	MyD88	MyD88	NNS
cord-007689-0vpp3xdl	97	18	,	,	,
cord-007689-0vpp3xdl	97	19	IRAK1	IRAK1	NNP
cord-007689-0vpp3xdl	97	20	,	,	,
cord-007689-0vpp3xdl	97	21	and	and	CC
cord-007689-0vpp3xdl	97	22	TRAF6	TRAF6	NNP
cord-007689-0vpp3xdl	97	23	,	,	,
cord-007689-0vpp3xdl	97	24	leading	lead	VBG
cord-007689-0vpp3xdl	97	25	to	to	IN
cord-007689-0vpp3xdl	97	26	activation	activation	NN
cord-007689-0vpp3xdl	97	27	of	of	IN
cord-007689-0vpp3xdl	97	28	IRF7	IRF7	NNP
cord-007689-0vpp3xdl	97	29	and	and	CC
cord-007689-0vpp3xdl	97	30	the	the	DT
cord-007689-0vpp3xdl	97	31	induction	induction	NN
cord-007689-0vpp3xdl	97	32	of	of	IN
cord-007689-0vpp3xdl	97	33	type	type	NN
cord-007689-0vpp3xdl	97	34	I	-PRON-	PRP
cord-007689-0vpp3xdl	97	35	interferons	interferon	NNS
cord-007689-0vpp3xdl	97	36	as	as	IN
cord-007689-0vpp3xdl	97	37	reviewed	review	VBN
cord-007689-0vpp3xdl	97	38	by	by	IN
cord-007689-0vpp3xdl	97	39	Moynagh	Moynagh	NNP
cord-007689-0vpp3xdl	97	40	(	(	-LRB-
cord-007689-0vpp3xdl	97	41	2005	2005	CD
cord-007689-0vpp3xdl	97	42	)	)	-RRB-
cord-007689-0vpp3xdl	97	43	.	.	.
cord-007689-0vpp3xdl	98	1	In	in	IN
cord-007689-0vpp3xdl	98	2	addition	addition	NN
cord-007689-0vpp3xdl	98	3	,	,	,
cord-007689-0vpp3xdl	98	4	recent	recent	JJ
cord-007689-0vpp3xdl	98	5	studies	study	NNS
cord-007689-0vpp3xdl	98	6	show	show	VBP
cord-007689-0vpp3xdl	98	7	that	that	IN
cord-007689-0vpp3xdl	98	8	TRAF3	TRAF3	NNP
cord-007689-0vpp3xdl	98	9	plays	play	VBZ
cord-007689-0vpp3xdl	98	10	a	a	DT
cord-007689-0vpp3xdl	98	11	crucial	crucial	JJ
cord-007689-0vpp3xdl	98	12	role	role	NN
cord-007689-0vpp3xdl	98	13	in	in	IN
cord-007689-0vpp3xdl	98	14	the	the	DT
cord-007689-0vpp3xdl	98	15	MyD88-dependent	MyD88-dependent	NNP
cord-007689-0vpp3xdl	98	16	signaling	signal	VBG
cord-007689-0vpp3xdl	98	17	cascade	cascade	NN
cord-007689-0vpp3xdl	98	18	(	(	-LRB-
cord-007689-0vpp3xdl	98	19	Hacker	Hacker	NNP
cord-007689-0vpp3xdl	98	20	et	et	NNP
cord-007689-0vpp3xdl	98	21	al	al	NNP
cord-007689-0vpp3xdl	98	22	.	.	NNP
cord-007689-0vpp3xdl	98	23	2005	2005	CD
cord-007689-0vpp3xdl	98	24	;	;	:
cord-007689-0vpp3xdl	98	25	Oganesyan	Oganesyan	NNP
cord-007689-0vpp3xdl	98	26	et	et	NNP
cord-007689-0vpp3xdl	98	27	al	al	NNP
cord-007689-0vpp3xdl	98	28	.	.	NNP
cord-007689-0vpp3xdl	98	29	2005	2005	CD
cord-007689-0vpp3xdl	98	30	)	)	-RRB-
cord-007689-0vpp3xdl	98	31	.	.	.
cord-007689-0vpp3xdl	99	1	Single	single	JJ
cord-007689-0vpp3xdl	99	2	-	-	HYPH
cord-007689-0vpp3xdl	99	3	stranded	strand	VBN
cord-007689-0vpp3xdl	99	4	DNA	dna	NN
cord-007689-0vpp3xdl	99	5	and	and	CC
cord-007689-0vpp3xdl	99	6	the	the	DT
cord-007689-0vpp3xdl	99	7	small	small	JJ
cord-007689-0vpp3xdl	99	8	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	99	9	compound	compound	NN
cord-007689-0vpp3xdl	99	10	R848	r848	NN
cord-007689-0vpp3xdl	99	11	had	have	VBD
cord-007689-0vpp3xdl	99	12	been	be	VBN
cord-007689-0vpp3xdl	99	13	shown	show	VBN
cord-007689-0vpp3xdl	99	14	to	to	TO
cord-007689-0vpp3xdl	99	15	induce	induce	VB
cord-007689-0vpp3xdl	99	16	IFN	IFN	NNP
cord-007689-0vpp3xdl	99	17	in	in	IN
cord-007689-0vpp3xdl	99	18	PDCs	pdc	NNS
cord-007689-0vpp3xdl	99	19	dependent	dependent	JJ
cord-007689-0vpp3xdl	99	20	on	on	IN
cord-007689-0vpp3xdl	99	21	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	99	22	and	and	CC
cord-007689-0vpp3xdl	99	23	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	99	24	,	,	,
cord-007689-0vpp3xdl	99	25	respectively	respectively	RB
cord-007689-0vpp3xdl	99	26	(	(	-LRB-
cord-007689-0vpp3xdl	99	27	Hemmi	Hemmi	NNP
cord-007689-0vpp3xdl	99	28	et	et	NNP
cord-007689-0vpp3xdl	99	29	al	al	NNP
cord-007689-0vpp3xdl	99	30	.	.	.
cord-007689-0vpp3xdl	100	1	2000	2000	CD
cord-007689-0vpp3xdl	101	1	(	(	-LRB-
cord-007689-0vpp3xdl	101	2	Hemmi	Hemmi	NNP
cord-007689-0vpp3xdl	101	3	et	et	NNP
cord-007689-0vpp3xdl	101	4	al	al	NNP
cord-007689-0vpp3xdl	101	5	.	.	NNP
cord-007689-0vpp3xdl	101	6	,	,	,
cord-007689-0vpp3xdl	101	7	2002	2002	CD
cord-007689-0vpp3xdl	102	1	Jurk	Jurk	NNP
cord-007689-0vpp3xdl	102	2	et	et	FW
cord-007689-0vpp3xdl	102	3	al	al	NNP
cord-007689-0vpp3xdl	102	4	.	.	.
cord-007689-0vpp3xdl	103	1	2002	2002	CD
cord-007689-0vpp3xdl	103	2	;	;	:
cord-007689-0vpp3xdl	103	3	Krug	Krug	NNP
cord-007689-0vpp3xdl	103	4	et	et	NNP
cord-007689-0vpp3xdl	103	5	al	al	NNP
cord-007689-0vpp3xdl	103	6	.	.	.
cord-007689-0vpp3xdl	104	1	2001b	2001b	CD
cord-007689-0vpp3xdl	105	1	;	;	:
cord-007689-0vpp3xdl	105	2	Rothenfusser	Rothenfusser	NNP
cord-007689-0vpp3xdl	105	3	et	et	NNP
cord-007689-0vpp3xdl	105	4	al	al	NNP
cord-007689-0vpp3xdl	105	5	.	.	.
cord-007689-0vpp3xdl	105	6	2002	2002	CD
cord-007689-0vpp3xdl	105	7	)	)	-RRB-
cord-007689-0vpp3xdl	105	8	.	.	.
cord-007689-0vpp3xdl	106	1	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	106	2	detects	detect	VBZ
cord-007689-0vpp3xdl	106	3	unmethylated	unmethylate	VBN
cord-007689-0vpp3xdl	106	4	so	so	RB
cord-007689-0vpp3xdl	106	5	-	-	HYPH
cord-007689-0vpp3xdl	106	6	called	call	VBN
cord-007689-0vpp3xdl	106	7	CpG	cpg	NN
cord-007689-0vpp3xdl	106	8	motifs	motif	NNS
cord-007689-0vpp3xdl	106	9	in	in	IN
cord-007689-0vpp3xdl	106	10	single	single	RB
cord-007689-0vpp3xdl	106	11	-	-	HYPH
cord-007689-0vpp3xdl	106	12	stranded	strand	VBN
cord-007689-0vpp3xdl	106	13	DNA	dna	NN
cord-007689-0vpp3xdl	106	14	(	(	-LRB-
cord-007689-0vpp3xdl	106	15	Hemmi	Hemmi	NNP
cord-007689-0vpp3xdl	106	16	et	et	NNP
cord-007689-0vpp3xdl	106	17	al	al	NNP
cord-007689-0vpp3xdl	106	18	.	.	.
cord-007689-0vpp3xdl	106	19	2000	2000	CD
cord-007689-0vpp3xdl	106	20	)	)	-RRB-
cord-007689-0vpp3xdl	106	21	.	.	.
cord-007689-0vpp3xdl	107	1	Different	different	JJ
cord-007689-0vpp3xdl	107	2	classes	class	NNS
cord-007689-0vpp3xdl	107	3	of	of	IN
cord-007689-0vpp3xdl	107	4	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	107	5	CpG	CpG	NNP
cord-007689-0vpp3xdl	107	6	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-007689-0vpp3xdl	107	7	(	(	-LRB-
cord-007689-0vpp3xdl	107	8	ODN	ODN	NNP
cord-007689-0vpp3xdl	107	9	)	)	-RRB-
cord-007689-0vpp3xdl	107	10	were	be	VBD
cord-007689-0vpp3xdl	107	11	developed	develop	VBN
cord-007689-0vpp3xdl	107	12	based	base	VBN
cord-007689-0vpp3xdl	107	13	on	on	IN
cord-007689-0vpp3xdl	107	14	the	the	DT
cord-007689-0vpp3xdl	107	15	distinct	distinct	JJ
cord-007689-0vpp3xdl	107	16	effects	effect	NNS
cord-007689-0vpp3xdl	107	17	on	on	IN
cord-007689-0vpp3xdl	107	18	the	the	DT
cord-007689-0vpp3xdl	107	19	two	two	CD
cord-007689-0vpp3xdl	107	20	TLR9-expressing	tlr9-expresse	VBG
cord-007689-0vpp3xdl	107	21	immune	immune	JJ
cord-007689-0vpp3xdl	107	22	cell	cell	NN
cord-007689-0vpp3xdl	107	23	types	type	NNS
cord-007689-0vpp3xdl	107	24	:	:	:
cord-007689-0vpp3xdl	107	25	PDCs	pdc	NNS
cord-007689-0vpp3xdl	107	26	and	and	CC
cord-007689-0vpp3xdl	107	27	B	b	NN
cord-007689-0vpp3xdl	107	28	cells	cell	NNS
cord-007689-0vpp3xdl	107	29	(	(	-LRB-
cord-007689-0vpp3xdl	107	30	Hartmann	Hartmann	NNP
cord-007689-0vpp3xdl	107	31	et	et	NNP
cord-007689-0vpp3xdl	107	32	al	al	NNP
cord-007689-0vpp3xdl	107	33	.	.	NNP
cord-007689-0vpp3xdl	107	34	2003	2003	CD
cord-007689-0vpp3xdl	107	35	;	;	:
cord-007689-0vpp3xdl	108	1	Hartmann	Hartmann	NNP
cord-007689-0vpp3xdl	108	2	and	and	CC
cord-007689-0vpp3xdl	108	3	Krieg	Krieg	NNP
cord-007689-0vpp3xdl	108	4	2000	2000	CD
cord-007689-0vpp3xdl	108	5	;	;	:
cord-007689-0vpp3xdl	108	6	Krug	Krug	NNP
cord-007689-0vpp3xdl	108	7	et	et	NNP
cord-007689-0vpp3xdl	108	8	al	al	NNP
cord-007689-0vpp3xdl	108	9	.	.	NNP
cord-007689-0vpp3xdl	108	10	2001a	2001a	CD
cord-007689-0vpp3xdl	108	11	)	)	-RRB-
cord-007689-0vpp3xdl	108	12	.	.	.
cord-007689-0vpp3xdl	109	1	In	in	IN
cord-007689-0vpp3xdl	109	2	contrast	contrast	NN
cord-007689-0vpp3xdl	109	3	to	to	IN
cord-007689-0vpp3xdl	109	4	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	109	5	,	,	,
cord-007689-0vpp3xdl	109	6	both	both	DT
cord-007689-0vpp3xdl	109	7	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	109	8	and	and	CC
cord-007689-0vpp3xdl	109	9	9	9	CD
cord-007689-0vpp3xdl	109	10	depend	depend	VBP
cord-007689-0vpp3xdl	109	11	on	on	IN
cord-007689-0vpp3xdl	109	12	the	the	DT
cord-007689-0vpp3xdl	109	13	signaling	signal	VBG
cord-007689-0vpp3xdl	109	14	adapter	adapter	NN
cord-007689-0vpp3xdl	109	15	MyD88	MyD88	NNS
cord-007689-0vpp3xdl	109	16	.	.	.
cord-007689-0vpp3xdl	110	1	Accordingly	accordingly	RB
cord-007689-0vpp3xdl	110	2	,	,	,
cord-007689-0vpp3xdl	110	3	PDCs	pdc	NNS
cord-007689-0vpp3xdl	110	4	derived	derive	VBN
cord-007689-0vpp3xdl	110	5	from	from	IN
cord-007689-0vpp3xdl	110	6	TLR9-or	TLR9-or	NNP
cord-007689-0vpp3xdl	111	1	MyD88-deficient	MyD88-deficient	NNP
cord-007689-0vpp3xdl	111	2	mice	mouse	NNS
cord-007689-0vpp3xdl	111	3	are	be	VBP
cord-007689-0vpp3xdl	111	4	unable	unable	JJ
cord-007689-0vpp3xdl	111	5	to	to	TO
cord-007689-0vpp3xdl	111	6	produce	produce	VB
cord-007689-0vpp3xdl	111	7	type	type	NN
cord-007689-0vpp3xdl	112	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	112	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	112	3	in	in	IN
cord-007689-0vpp3xdl	112	4	response	response	NN
cord-007689-0vpp3xdl	112	5	to	to	IN
cord-007689-0vpp3xdl	112	6	DNA	dna	NN
cord-007689-0vpp3xdl	112	7	viruses	virus	NNS
cord-007689-0vpp3xdl	112	8	such	such	JJ
cord-007689-0vpp3xdl	112	9	as	as	IN
cord-007689-0vpp3xdl	112	10	herpes	herpes	NN
cord-007689-0vpp3xdl	112	11	simplex	simplex	NNP
cord-007689-0vpp3xdl	112	12	viruses	virus	NNS
cord-007689-0vpp3xdl	112	13	(	(	-LRB-
cord-007689-0vpp3xdl	112	14	HSV	HSV	NNP
cord-007689-0vpp3xdl	112	15	)	)	-RRB-
cord-007689-0vpp3xdl	112	16	and	and	CC
cord-007689-0vpp3xdl	112	17	murine	murine	JJ
cord-007689-0vpp3xdl	112	18	cytomegalovirus	cytomegalovirus	NN
cord-007689-0vpp3xdl	112	19	(	(	-LRB-
cord-007689-0vpp3xdl	112	20	MCMV	MCMV	NNP
cord-007689-0vpp3xdl	112	21	)	)	-RRB-
cord-007689-0vpp3xdl	113	1	(	(	-LRB-
cord-007689-0vpp3xdl	113	2	Krug	Krug	NNP
cord-007689-0vpp3xdl	113	3	et	et	NNP
cord-007689-0vpp3xdl	113	4	al	al	NNP
cord-007689-0vpp3xdl	113	5	.	.	.
cord-007689-0vpp3xdl	114	1	2004a	2004a	CD
cord-007689-0vpp3xdl	115	1	(	(	-LRB-
cord-007689-0vpp3xdl	115	2	Krug	Krug	NNP
cord-007689-0vpp3xdl	115	3	et	et	NNP
cord-007689-0vpp3xdl	115	4	al	al	NNP
cord-007689-0vpp3xdl	115	5	.	.	NNP
cord-007689-0vpp3xdl	115	6	,	,	,
cord-007689-0vpp3xdl	116	1	2004b	2004b	CD
cord-007689-0vpp3xdl	116	2	Lund	Lund	NNP
cord-007689-0vpp3xdl	116	3	et	et	NNP
cord-007689-0vpp3xdl	116	4	al	al	NNP
cord-007689-0vpp3xdl	116	5	.	.	.
cord-007689-0vpp3xdl	117	1	2003	2003	CD
cord-007689-0vpp3xdl	117	2	;	;	:
cord-007689-0vpp3xdl	117	3	Tabeta	Tabeta	NNP
cord-007689-0vpp3xdl	117	4	et	et	FW
cord-007689-0vpp3xdl	117	5	al	al	NNP
cord-007689-0vpp3xdl	117	6	.	.	.
cord-007689-0vpp3xdl	117	7	2004	2004	CD
cord-007689-0vpp3xdl	117	8	)	)	-RRB-
cord-007689-0vpp3xdl	117	9	.	.	.
cord-007689-0vpp3xdl	118	1	While	while	IN
cord-007689-0vpp3xdl	118	2	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	118	3	was	be	VBD
cord-007689-0vpp3xdl	118	4	responsible	responsible	JJ
cord-007689-0vpp3xdl	118	5	for	for	IN
cord-007689-0vpp3xdl	118	6	detecting	detect	VBG
cord-007689-0vpp3xdl	118	7	viral	viral	JJ
cord-007689-0vpp3xdl	118	8	DNA	dna	NN
cord-007689-0vpp3xdl	118	9	,	,	,
cord-007689-0vpp3xdl	118	10	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	118	11	was	be	VBD
cord-007689-0vpp3xdl	118	12	shown	show	VBN
cord-007689-0vpp3xdl	118	13	to	to	TO
cord-007689-0vpp3xdl	118	14	recognize	recognize	VB
cord-007689-0vpp3xdl	118	15	RNA	RNA	NNP
cord-007689-0vpp3xdl	118	16	:	:	:
cord-007689-0vpp3xdl	119	1	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	119	2	detects	detect	VBZ
cord-007689-0vpp3xdl	119	3	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	119	4	short	short	JJ
cord-007689-0vpp3xdl	119	5	(	(	-LRB-
cord-007689-0vpp3xdl	119	6	20	20	CD
cord-007689-0vpp3xdl	119	7	-	-	SYM
cord-007689-0vpp3xdl	119	8	27	27	CD
cord-007689-0vpp3xdl	119	9	bases	basis	NNS
cord-007689-0vpp3xdl	119	10	)	)	-RRB-
cord-007689-0vpp3xdl	119	11	single	single	RB
cord-007689-0vpp3xdl	119	12	-	-	HYPH
cord-007689-0vpp3xdl	119	13	stranded	strand	VBN
cord-007689-0vpp3xdl	119	14	RNA	RNA	NNP
cord-007689-0vpp3xdl	119	15	(	(	-LRB-
cord-007689-0vpp3xdl	119	16	Diebold	Diebold	NNP
cord-007689-0vpp3xdl	119	17	et	et	FW
cord-007689-0vpp3xdl	119	18	al	al	NNP
cord-007689-0vpp3xdl	119	19	.	.	.
cord-007689-0vpp3xdl	119	20	2004	2004	CD
cord-007689-0vpp3xdl	119	21	;	;	:
cord-007689-0vpp3xdl	119	22	Heil	Heil	NNP
cord-007689-0vpp3xdl	119	23	et	et	NNP
cord-007689-0vpp3xdl	119	24	al	al	NNP
cord-007689-0vpp3xdl	119	25	.	.	.
cord-007689-0vpp3xdl	119	26	2004	2004	CD
cord-007689-0vpp3xdl	119	27	)	)	-RRB-
cord-007689-0vpp3xdl	119	28	and	and	CC
cord-007689-0vpp3xdl	119	29	short	short	JJ
cord-007689-0vpp3xdl	119	30	interfering	interfere	VBG
cord-007689-0vpp3xdl	119	31	double	double	RB
cord-007689-0vpp3xdl	119	32	-	-	HYPH
cord-007689-0vpp3xdl	119	33	stranded	strand	VBN
cord-007689-0vpp3xdl	119	34	RNA	RNA	NNP
cord-007689-0vpp3xdl	119	35	(	(	-LRB-
cord-007689-0vpp3xdl	119	36	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	119	37	)	)	-RRB-
cord-007689-0vpp3xdl	120	1	(	(	-LRB-
cord-007689-0vpp3xdl	120	2	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	120	3	et	et	NNP
cord-007689-0vpp3xdl	120	4	al	al	NNP
cord-007689-0vpp3xdl	120	5	.	.	.
cord-007689-0vpp3xdl	120	6	2005	2005	CD
cord-007689-0vpp3xdl	121	1	;	;	:
cord-007689-0vpp3xdl	121	2	Judge	Judge	NNP
cord-007689-0vpp3xdl	121	3	et	et	NNP
cord-007689-0vpp3xdl	121	4	al	al	NNP
cord-007689-0vpp3xdl	121	5	.	.	.
cord-007689-0vpp3xdl	122	1	2005	2005	CD
cord-007689-0vpp3xdl	122	2	;	;	:
cord-007689-0vpp3xdl	122	3	Sioud	Sioud	NNP
cord-007689-0vpp3xdl	122	4	2005	2005	CD
cord-007689-0vpp3xdl	122	5	;	;	:
cord-007689-0vpp3xdl	122	6	reviewed	review	VBN
cord-007689-0vpp3xdl	122	7	in	in	IN
cord-007689-0vpp3xdl	122	8	Schlee	Schlee	NNP
cord-007689-0vpp3xdl	122	9	et	et	NNP
cord-007689-0vpp3xdl	122	10	al	al	NNP
cord-007689-0vpp3xdl	122	11	.	.	.
cord-007689-0vpp3xdl	122	12	2006	2006	CD
cord-007689-0vpp3xdl	122	13	)	)	-RRB-
cord-007689-0vpp3xdl	122	14	.	.	.
cord-007689-0vpp3xdl	123	1	The	the	DT
cord-007689-0vpp3xdl	123	2	amount	amount	NN
cord-007689-0vpp3xdl	123	3	of	of	IN
cord-007689-0vpp3xdl	123	4	type	type	NN
cord-007689-0vpp3xdl	123	5	I	-PRON-	PRP
cord-007689-0vpp3xdl	123	6	interferon	interferon	VBD
cord-007689-0vpp3xdl	123	7	induction	induction	NN
cord-007689-0vpp3xdl	123	8	was	be	VBD
cord-007689-0vpp3xdl	123	9	dependent	dependent	JJ
cord-007689-0vpp3xdl	123	10	on	on	IN
cord-007689-0vpp3xdl	123	11	the	the	DT
cord-007689-0vpp3xdl	123	12	RNA	RNA	NNP
cord-007689-0vpp3xdl	123	13	sequence	sequence	NN
cord-007689-0vpp3xdl	123	14	.	.	.
cord-007689-0vpp3xdl	124	1	Ironically	ironically	RB
cord-007689-0vpp3xdl	124	2	,	,	,
cord-007689-0vpp3xdl	124	3	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	124	4	and	and	CC
cord-007689-0vpp3xdl	124	5	colleagues	colleague	NNS
cord-007689-0vpp3xdl	124	6	came	come	VBD
cord-007689-0vpp3xdl	124	7	across	across	IN
cord-007689-0vpp3xdl	124	8	a	a	DT
cord-007689-0vpp3xdl	124	9	very	very	RB
cord-007689-0vpp3xdl	124	10	potent	potent	JJ
cord-007689-0vpp3xdl	124	11	type	type	NN
cord-007689-0vpp3xdl	124	12	I	-PRON-	PRP
cord-007689-0vpp3xdl	124	13	interferon	interferon	VBD
cord-007689-0vpp3xdl	124	14	inducing	induce	VBG
cord-007689-0vpp3xdl	124	15	small	small	JJ
cord-007689-0vpp3xdl	124	16	RNA	RNA	NNP
cord-007689-0vpp3xdl	124	17	sequence	sequence	NN
cord-007689-0vpp3xdl	124	18	core	core	NN
cord-007689-0vpp3xdl	124	19	motif	motif	NN
cord-007689-0vpp3xdl	124	20	(	(	-LRB-
cord-007689-0vpp3xdl	124	21	5′-GUCCUUCAA-3′	5′-guccuucaa-3′	CD
cord-007689-0vpp3xdl	124	22	)	)	-RRB-
cord-007689-0vpp3xdl	124	23	in	in	IN
cord-007689-0vpp3xdl	124	24	the	the	DT
cord-007689-0vpp3xdl	124	25	attempt	attempt	NN
cord-007689-0vpp3xdl	124	26	to	to	TO
cord-007689-0vpp3xdl	124	27	knock	knock	VB
cord-007689-0vpp3xdl	124	28	down	down	RP
cord-007689-0vpp3xdl	124	29	the	the	DT
cord-007689-0vpp3xdl	124	30	interferon	interferon	NN
cord-007689-0vpp3xdl	124	31	inducer	inducer	NN
cord-007689-0vpp3xdl	124	32	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	124	33	in	in	IN
cord-007689-0vpp3xdl	124	34	PDCs	pdc	NNS
cord-007689-0vpp3xdl	124	35	using	use	VBG
cord-007689-0vpp3xdl	124	36	the	the	DT
cord-007689-0vpp3xdl	124	37	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	124	38	technology	technology	NN
cord-007689-0vpp3xdl	124	39	(	(	-LRB-
cord-007689-0vpp3xdl	124	40	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	124	41	et	et	NNP
cord-007689-0vpp3xdl	124	42	al	al	NNP
cord-007689-0vpp3xdl	124	43	.	.	NNP
cord-007689-0vpp3xdl	124	44	2005	2005	CD
cord-007689-0vpp3xdl	124	45	)	)	-RRB-
cord-007689-0vpp3xdl	124	46	.	.	.
cord-007689-0vpp3xdl	125	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	125	2	was	be	VBD
cord-007689-0vpp3xdl	125	3	demonstrated	demonstrate	VBN
cord-007689-0vpp3xdl	125	4	that	that	IN
cord-007689-0vpp3xdl	125	5	these	these	DT
cord-007689-0vpp3xdl	125	6	siRNAs	sirna	NNS
cord-007689-0vpp3xdl	125	7	induce	induce	VBP
cord-007689-0vpp3xdl	125	8	systemic	systemic	JJ
cord-007689-0vpp3xdl	125	9	immune	immune	JJ
cord-007689-0vpp3xdl	125	10	activation	activation	NN
cord-007689-0vpp3xdl	125	11	in	in	IN
cord-007689-0vpp3xdl	125	12	mice	mouse	NNS
cord-007689-0vpp3xdl	125	13	,	,	,
cord-007689-0vpp3xdl	125	14	and	and	CC
cord-007689-0vpp3xdl	125	15	that	that	IN
cord-007689-0vpp3xdl	125	16	the	the	DT
cord-007689-0vpp3xdl	125	17	immunological	immunological	JJ
cord-007689-0vpp3xdl	125	18	activity	activity	NN
cord-007689-0vpp3xdl	125	19	required	require	VBD
cord-007689-0vpp3xdl	125	20	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	125	21	.	.	.
cord-007689-0vpp3xdl	126	1	Of	of	IN
cord-007689-0vpp3xdl	126	2	note	note	NN
cord-007689-0vpp3xdl	126	3	,	,	,
cord-007689-0vpp3xdl	126	4	the	the	DT
cord-007689-0vpp3xdl	126	5	same	same	JJ
cord-007689-0vpp3xdl	126	6	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	126	7	did	do	VBD
cord-007689-0vpp3xdl	126	8	not	not	RB
cord-007689-0vpp3xdl	126	9	induce	induce	VB
cord-007689-0vpp3xdl	126	10	type	type	NN
cord-007689-0vpp3xdl	127	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	127	2	interferon	interferon	VBD
cord-007689-0vpp3xdl	127	3	in	in	IN
cord-007689-0vpp3xdl	127	4	immortalized	immortalize	VBN
cord-007689-0vpp3xdl	127	5	human	human	JJ
cord-007689-0vpp3xdl	127	6	embryonic	embryonic	JJ
cord-007689-0vpp3xdl	127	7	kidney	kidney	NN
cord-007689-0vpp3xdl	127	8	cells	cell	NNS
cord-007689-0vpp3xdl	127	9	(	(	-LRB-
cord-007689-0vpp3xdl	127	10	HEK293	HEK293	NNP
cord-007689-0vpp3xdl	127	11	)	)	-RRB-
cord-007689-0vpp3xdl	127	12	,	,	,
cord-007689-0vpp3xdl	127	13	which	which	WDT
cord-007689-0vpp3xdl	127	14	produced	produce	VBD
cord-007689-0vpp3xdl	127	15	type	type	NN
cord-007689-0vpp3xdl	128	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	128	2	interferon	interferon	VBD
cord-007689-0vpp3xdl	128	3	in	in	IN
cord-007689-0vpp3xdl	128	4	response	response	NN
cord-007689-0vpp3xdl	128	5	to	to	IN
cord-007689-0vpp3xdl	128	6	poly	poly	NNP
cord-007689-0vpp3xdl	128	7	I	I	NNP
cord-007689-0vpp3xdl	128	8	:	:	:
cord-007689-0vpp3xdl	128	9	C.	c.	NN
cord-007689-0vpp3xdl	129	1	In	in	IN
cord-007689-0vpp3xdl	129	2	subsequent	subsequent	JJ
cord-007689-0vpp3xdl	129	3	studies	study	NNS
cord-007689-0vpp3xdl	129	4	,	,	,
cord-007689-0vpp3xdl	129	5	similar	similar	JJ
cord-007689-0vpp3xdl	129	6	findings	finding	NNS
cord-007689-0vpp3xdl	129	7	were	be	VBD
cord-007689-0vpp3xdl	129	8	reported	report	VBN
cord-007689-0vpp3xdl	129	9	by	by	IN
cord-007689-0vpp3xdl	129	10	Judge	Judge	NNP
cord-007689-0vpp3xdl	129	11	et	et	NNP
cord-007689-0vpp3xdl	129	12	al	al	NNP
cord-007689-0vpp3xdl	129	13	.	.	.
cord-007689-0vpp3xdl	130	1	(	(	-LRB-
cord-007689-0vpp3xdl	130	2	2005	2005	CD
cord-007689-0vpp3xdl	130	3	)	)	-RRB-
cord-007689-0vpp3xdl	131	1	(	(	-LRB-
cord-007689-0vpp3xdl	131	2	identifying	identify	VBG
cord-007689-0vpp3xdl	131	3	a	a	DT
cord-007689-0vpp3xdl	131	4	core	core	NN
cord-007689-0vpp3xdl	131	5	motif	motif	NN
cord-007689-0vpp3xdl	131	6	5′-UGUGU-3′	5′-ugugu-3′	CD
cord-007689-0vpp3xdl	131	7	)	)	-RRB-
cord-007689-0vpp3xdl	131	8	and	and	CC
cord-007689-0vpp3xdl	131	9	Sioud	Sioud	NNP
cord-007689-0vpp3xdl	131	10	(	(	-LRB-
cord-007689-0vpp3xdl	131	11	2005	2005	CD
cord-007689-0vpp3xdl	131	12	)	)	-RRB-
cord-007689-0vpp3xdl	131	13	.	.	.
cord-007689-0vpp3xdl	132	1	In	in	IN
cord-007689-0vpp3xdl	132	2	all	all	DT
cord-007689-0vpp3xdl	132	3	three	three	CD
cord-007689-0vpp3xdl	132	4	studies	study	NNS
cord-007689-0vpp3xdl	132	5	,	,	,
cord-007689-0vpp3xdl	132	6	transfection	transfection	NN
cord-007689-0vpp3xdl	132	7	with	with	IN
cord-007689-0vpp3xdl	132	8	cationic	cationic	JJ
cord-007689-0vpp3xdl	132	9	lipids	lipid	NNS
cord-007689-0vpp3xdl	132	10	(	(	-LRB-
cord-007689-0vpp3xdl	132	11	e.g.	e.g.	RB
cord-007689-0vpp3xdl	132	12	,	,	,
cord-007689-0vpp3xdl	132	13	DOTAP	DOTAP	NNP
cord-007689-0vpp3xdl	132	14	,	,	,
cord-007689-0vpp3xdl	132	15	lipofectamine	lipofectamine	NN
cord-007689-0vpp3xdl	132	16	)	)	-RRB-
cord-007689-0vpp3xdl	132	17	or	or	CC
cord-007689-0vpp3xdl	132	18	cationic	cationic	JJ
cord-007689-0vpp3xdl	132	19	polymers	polymer	NNS
cord-007689-0vpp3xdl	132	20	(	(	-LRB-
cord-007689-0vpp3xdl	132	21	e.g.	e.g.	RB
cord-007689-0vpp3xdl	132	22	,	,	,
cord-007689-0vpp3xdl	132	23	PEI	PEI	NNP
cord-007689-0vpp3xdl	132	24	,	,	,
cord-007689-0vpp3xdl	132	25	polyethylenimine	polyethylenimine	NNP
cord-007689-0vpp3xdl	132	26	)	)	-RRB-
cord-007689-0vpp3xdl	132	27	was	be	VBD
cord-007689-0vpp3xdl	132	28	essential	essential	JJ
cord-007689-0vpp3xdl	132	29	for	for	IN
cord-007689-0vpp3xdl	132	30	the	the	DT
cord-007689-0vpp3xdl	132	31	immunological	immunological	JJ
cord-007689-0vpp3xdl	132	32	activity	activity	NN
cord-007689-0vpp3xdl	132	33	of	of	IN
cord-007689-0vpp3xdl	132	34	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	132	35	.	.	.
cord-007689-0vpp3xdl	133	1	The	the	DT
cord-007689-0vpp3xdl	133	2	same	same	JJ
cord-007689-0vpp3xdl	133	3	applies	apply	VBZ
cord-007689-0vpp3xdl	133	4	for	for	IN
cord-007689-0vpp3xdl	133	5	the	the	DT
cord-007689-0vpp3xdl	133	6	immunological	immunological	JJ
cord-007689-0vpp3xdl	133	7	activity	activity	NN
cord-007689-0vpp3xdl	133	8	of	of	IN
cord-007689-0vpp3xdl	133	9	single	single	RB
cord-007689-0vpp3xdl	133	10	-	-	HYPH
cord-007689-0vpp3xdl	133	11	stranded	strand	VBN
cord-007689-0vpp3xdl	133	12	RNA	RNA	NNP
cord-007689-0vpp3xdl	133	13	(	(	-LRB-
cord-007689-0vpp3xdl	133	14	Diebold	Diebold	NNP
cord-007689-0vpp3xdl	133	15	et	et	FW
cord-007689-0vpp3xdl	133	16	al	al	NNP
cord-007689-0vpp3xdl	133	17	.	.	.
cord-007689-0vpp3xdl	133	18	2004	2004	CD
cord-007689-0vpp3xdl	133	19	;	;	:
cord-007689-0vpp3xdl	133	20	Heil	Heil	NNP
cord-007689-0vpp3xdl	133	21	et	et	NNP
cord-007689-0vpp3xdl	133	22	al	al	NNP
cord-007689-0vpp3xdl	133	23	.	.	.
cord-007689-0vpp3xdl	133	24	2004	2004	CD
cord-007689-0vpp3xdl	133	25	;	;	:
cord-007689-0vpp3xdl	133	26	Scheel	Scheel	NNP
cord-007689-0vpp3xdl	133	27	et	et	NNP
cord-007689-0vpp3xdl	133	28	al	al	NNP
cord-007689-0vpp3xdl	133	29	.	.	NNP
cord-007689-0vpp3xdl	133	30	2005	2005	CD
cord-007689-0vpp3xdl	133	31	)	)	-RRB-
cord-007689-0vpp3xdl	133	32	.	.	.
cord-007689-0vpp3xdl	134	1	While	while	IN
cord-007689-0vpp3xdl	134	2	for	for	IN
cord-007689-0vpp3xdl	134	3	short	short	JJ
cord-007689-0vpp3xdl	134	4	RNA	RNA	NNP
cord-007689-0vpp3xdl	134	5	oligonucleotides	oligonucleotide	NNS
cord-007689-0vpp3xdl	134	6	the	the	DT
cord-007689-0vpp3xdl	134	7	immunological	immunological	JJ
cord-007689-0vpp3xdl	134	8	activity	activity	NN
cord-007689-0vpp3xdl	134	9	is	be	VBZ
cord-007689-0vpp3xdl	134	10	clearly	clearly	RB
cord-007689-0vpp3xdl	134	11	sequence	sequence	NN
cord-007689-0vpp3xdl	134	12	dependent	dependent	JJ
cord-007689-0vpp3xdl	135	1	(	(	-LRB-
cord-007689-0vpp3xdl	135	2	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	135	3	et	et	NNP
cord-007689-0vpp3xdl	135	4	al	al	NNP
cord-007689-0vpp3xdl	135	5	.	.	.
cord-007689-0vpp3xdl	135	6	2005	2005	CD
cord-007689-0vpp3xdl	136	1	;	;	:
cord-007689-0vpp3xdl	136	2	Judge	Judge	NNP
cord-007689-0vpp3xdl	136	3	et	et	NNP
cord-007689-0vpp3xdl	136	4	al	al	NNP
cord-007689-0vpp3xdl	136	5	.	.	NNP
cord-007689-0vpp3xdl	136	6	2005	2005	CD
cord-007689-0vpp3xdl	136	7	)	)	-RRB-
cord-007689-0vpp3xdl	136	8	,	,	,
cord-007689-0vpp3xdl	136	9	for	for	IN
cord-007689-0vpp3xdl	136	10	long	long	JJ
cord-007689-0vpp3xdl	136	11	RNA	RNA	NNP
cord-007689-0vpp3xdl	136	12	molecules	molecule	NNS
cord-007689-0vpp3xdl	136	13	such	such	JJ
cord-007689-0vpp3xdl	136	14	as	as	IN
cord-007689-0vpp3xdl	136	15	mRNA	mrna	NN
cord-007689-0vpp3xdl	136	16	,	,	,
cord-007689-0vpp3xdl	136	17	sequence	sequence	NN
cord-007689-0vpp3xdl	136	18	specificity	specificity	NN
cord-007689-0vpp3xdl	136	19	of	of	IN
cord-007689-0vpp3xdl	136	20	immunological	immunological	JJ
cord-007689-0vpp3xdl	136	21	activity	activity	NN
cord-007689-0vpp3xdl	136	22	is	be	VBZ
cord-007689-0vpp3xdl	136	23	less	less	RBR
cord-007689-0vpp3xdl	136	24	prominent	prominent	JJ
cord-007689-0vpp3xdl	136	25	(	(	-LRB-
cord-007689-0vpp3xdl	136	26	Scheel	Scheel	NNP
cord-007689-0vpp3xdl	136	27	et	et	NNP
cord-007689-0vpp3xdl	136	28	al	al	NNP
cord-007689-0vpp3xdl	136	29	.	.	NNP
cord-007689-0vpp3xdl	136	30	2005	2005	CD
cord-007689-0vpp3xdl	136	31	)	)	-RRB-
cord-007689-0vpp3xdl	136	32	.	.	.
cord-007689-0vpp3xdl	137	1	This	this	DT
cord-007689-0vpp3xdl	137	2	raises	raise	VBZ
cord-007689-0vpp3xdl	137	3	the	the	DT
cord-007689-0vpp3xdl	137	4	question	question	NN
cord-007689-0vpp3xdl	137	5	of	of	IN
cord-007689-0vpp3xdl	137	6	how	how	WRB
cord-007689-0vpp3xdl	137	7	the	the	DT
cord-007689-0vpp3xdl	137	8	immune	immune	JJ
cord-007689-0vpp3xdl	137	9	system	system	NN
cord-007689-0vpp3xdl	137	10	is	be	VBZ
cord-007689-0vpp3xdl	137	11	able	able	JJ
cord-007689-0vpp3xdl	137	12	to	to	TO
cord-007689-0vpp3xdl	137	13	distinguish	distinguish	VB
cord-007689-0vpp3xdl	137	14	between	between	IN
cord-007689-0vpp3xdl	137	15	self	self	NN
cord-007689-0vpp3xdl	137	16	and	and	CC
cord-007689-0vpp3xdl	137	17	non	non	JJ
cord-007689-0vpp3xdl	137	18	-	-	JJ
cord-007689-0vpp3xdl	137	19	self	self	JJ
cord-007689-0vpp3xdl	137	20	(	(	-LRB-
cord-007689-0vpp3xdl	137	21	for	for	IN
cord-007689-0vpp3xdl	137	22	example	example	NN
cord-007689-0vpp3xdl	137	23	viral	viral	JJ
cord-007689-0vpp3xdl	137	24	)	)	-RRB-
cord-007689-0vpp3xdl	137	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	137	26	.	.	.
cord-007689-0vpp3xdl	138	1	This	this	DT
cord-007689-0vpp3xdl	138	2	question	question	NN
cord-007689-0vpp3xdl	138	3	was	be	VBD
cord-007689-0vpp3xdl	138	4	addressed	address	VBN
cord-007689-0vpp3xdl	138	5	recently	recently	RB
cord-007689-0vpp3xdl	138	6	by	by	IN
cord-007689-0vpp3xdl	138	7	Kariko	Kariko	NNP
cord-007689-0vpp3xdl	138	8	and	and	CC
cord-007689-0vpp3xdl	138	9	colleagues	colleague	NNS
cord-007689-0vpp3xdl	138	10	(	(	-LRB-
cord-007689-0vpp3xdl	138	11	2005	2005	CD
cord-007689-0vpp3xdl	138	12	)	)	-RRB-
cord-007689-0vpp3xdl	138	13	who	who	WP
cord-007689-0vpp3xdl	138	14	showed	show	VBD
cord-007689-0vpp3xdl	138	15	that	that	IN
cord-007689-0vpp3xdl	138	16	human	human	JJ
cord-007689-0vpp3xdl	138	17	mitochondrial	mitochondrial	NN
cord-007689-0vpp3xdl	138	18	RNA	RNA	NNP
cord-007689-0vpp3xdl	138	19	,	,	,
cord-007689-0vpp3xdl	138	20	when	when	WRB
cord-007689-0vpp3xdl	138	21	transfected	transfecte	VBN
cord-007689-0vpp3xdl	138	22	into	into	IN
cord-007689-0vpp3xdl	138	23	monocyte	monocyte	NNP
cord-007689-0vpp3xdl	138	24	-	-	HYPH
cord-007689-0vpp3xdl	138	25	derived	derive	VBN
cord-007689-0vpp3xdl	138	26	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	138	27	cells	cell	NNS
cord-007689-0vpp3xdl	138	28	,	,	,
cord-007689-0vpp3xdl	138	29	provoked	provoke	VBD
cord-007689-0vpp3xdl	138	30	secretion	secretion	NN
cord-007689-0vpp3xdl	138	31	of	of	IN
cord-007689-0vpp3xdl	138	32	TNF	TNF	NNP
cord-007689-0vpp3xdl	138	33	-	-	HYPH
cord-007689-0vpp3xdl	138	34	α	α	NNP
cord-007689-0vpp3xdl	138	35	at	at	IN
cord-007689-0vpp3xdl	138	36	similar	similar	JJ
cord-007689-0vpp3xdl	138	37	quantities	quantity	NNS
cord-007689-0vpp3xdl	138	38	compared	compare	VBN
cord-007689-0vpp3xdl	138	39	to	to	IN
cord-007689-0vpp3xdl	138	40	total	total	JJ
cord-007689-0vpp3xdl	138	41	RNA	RNA	NNP
cord-007689-0vpp3xdl	138	42	isolated	isolate	VBN
cord-007689-0vpp3xdl	138	43	from	from	IN
cord-007689-0vpp3xdl	138	44	Escherichia	Escherichia	NNP
cord-007689-0vpp3xdl	138	45	coli	coli	NNS
cord-007689-0vpp3xdl	138	46	.	.	.
cord-007689-0vpp3xdl	139	1	In	in	IN
cord-007689-0vpp3xdl	139	2	contrast	contrast	NN
cord-007689-0vpp3xdl	139	3	,	,	,
cord-007689-0vpp3xdl	139	4	RNA	RNA	NNP
cord-007689-0vpp3xdl	139	5	of	of	IN
cord-007689-0vpp3xdl	139	6	other	other	JJ
cord-007689-0vpp3xdl	139	7	cellular	cellular	JJ
cord-007689-0vpp3xdl	139	8	compartments	compartment	NNS
cord-007689-0vpp3xdl	139	9	showed	show	VBD
cord-007689-0vpp3xdl	139	10	no	no	DT
cord-007689-0vpp3xdl	139	11	immunological	immunological	JJ
cord-007689-0vpp3xdl	139	12	activity	activity	NN
cord-007689-0vpp3xdl	139	13	.	.	.
cord-007689-0vpp3xdl	140	1	The	the	DT
cord-007689-0vpp3xdl	140	2	authors	author	NNS
cord-007689-0vpp3xdl	140	3	proposed	propose	VBD
cord-007689-0vpp3xdl	140	4	that	that	IN
cord-007689-0vpp3xdl	140	5	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	140	6	RNA	RNA	NNP
cord-007689-0vpp3xdl	140	7	is	be	VBZ
cord-007689-0vpp3xdl	140	8	masked	mask	VBN
cord-007689-0vpp3xdl	140	9	by	by	IN
cord-007689-0vpp3xdl	140	10	naturally	naturally	RB
cord-007689-0vpp3xdl	140	11	occurring	occur	VBG
cord-007689-0vpp3xdl	140	12	nucleoside	nucleoside	NN
cord-007689-0vpp3xdl	140	13	modifications	modification	NNS
cord-007689-0vpp3xdl	140	14	that	that	WDT
cord-007689-0vpp3xdl	140	15	are	be	VBP
cord-007689-0vpp3xdl	140	16	expected	expect	VBN
cord-007689-0vpp3xdl	140	17	to	to	TO
cord-007689-0vpp3xdl	140	18	be	be	VB
cord-007689-0vpp3xdl	140	19	similar	similar	JJ
cord-007689-0vpp3xdl	140	20	in	in	IN
cord-007689-0vpp3xdl	140	21	closely	closely	RB
cord-007689-0vpp3xdl	140	22	related	relate	VBN
cord-007689-0vpp3xdl	140	23	species	specie	NNS
cord-007689-0vpp3xdl	140	24	.	.	.
cord-007689-0vpp3xdl	141	1	According	accord	VBG
cord-007689-0vpp3xdl	141	2	to	to	IN
cord-007689-0vpp3xdl	141	3	this	this	DT
cord-007689-0vpp3xdl	141	4	concept	concept	NN
cord-007689-0vpp3xdl	141	5	,	,	,
cord-007689-0vpp3xdl	141	6	mitochondrial	mitochondrial	NN
cord-007689-0vpp3xdl	141	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	141	8	is	be	VBZ
cord-007689-0vpp3xdl	141	9	stimulatory	stimulatory	JJ
cord-007689-0vpp3xdl	141	10	since	since	IN
cord-007689-0vpp3xdl	141	11	it	-PRON-	PRP
cord-007689-0vpp3xdl	141	12	resembles	resemble	VBZ
cord-007689-0vpp3xdl	141	13	bacterial	bacterial	JJ
cord-007689-0vpp3xdl	141	14	rather	rather	RB
cord-007689-0vpp3xdl	141	15	than	than	IN
cord-007689-0vpp3xdl	141	16	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	141	17	RNA	RNA	NNP
cord-007689-0vpp3xdl	141	18	.	.	.
cord-007689-0vpp3xdl	142	1	In	in	IN
cord-007689-0vpp3xdl	142	2	healthy	healthy	JJ
cord-007689-0vpp3xdl	142	3	cells	cell	NNS
cord-007689-0vpp3xdl	142	4	,	,	,
cord-007689-0vpp3xdl	142	5	mitochondrial	mitochondrial	JJ
cord-007689-0vpp3xdl	142	6	RNA	RNA	NNP
cord-007689-0vpp3xdl	142	7	will	will	MD
cord-007689-0vpp3xdl	142	8	not	not	RB
cord-007689-0vpp3xdl	142	9	be	be	VB
cord-007689-0vpp3xdl	142	10	released	release	VBN
cord-007689-0vpp3xdl	142	11	.	.	.
cord-007689-0vpp3xdl	143	1	In	in	IN
cord-007689-0vpp3xdl	143	2	contrast	contrast	NN
cord-007689-0vpp3xdl	143	3	to	to	IN
cord-007689-0vpp3xdl	143	4	other	other	JJ
cord-007689-0vpp3xdl	143	5	self	self	NN
cord-007689-0vpp3xdl	143	6	-	-	HYPH
cord-007689-0vpp3xdl	143	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	143	8	,	,	,
cord-007689-0vpp3xdl	143	9	mitochondrial	mitochondrial	NN
cord-007689-0vpp3xdl	143	10	RNA	RNA	NNP
cord-007689-0vpp3xdl	143	11	never	never	RB
cord-007689-0vpp3xdl	143	12	enters	enter	VBZ
cord-007689-0vpp3xdl	143	13	the	the	DT
cord-007689-0vpp3xdl	143	14	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	143	15	compartment	compartment	NN
cord-007689-0vpp3xdl	143	16	.	.	.
cord-007689-0vpp3xdl	144	1	As	as	IN
cord-007689-0vpp3xdl	144	2	a	a	DT
cord-007689-0vpp3xdl	144	3	consequence	consequence	NN
cord-007689-0vpp3xdl	144	4	,	,	,
cord-007689-0vpp3xdl	144	5	mitochondrial	mitochondrial	JJ
cord-007689-0vpp3xdl	144	6	RNA	RNA	NNP
cord-007689-0vpp3xdl	144	7	under	under	IN
cord-007689-0vpp3xdl	144	8	healthy	healthy	JJ
cord-007689-0vpp3xdl	144	9	conditions	condition	NNS
cord-007689-0vpp3xdl	144	10	is	be	VBZ
cord-007689-0vpp3xdl	144	11	not	not	RB
cord-007689-0vpp3xdl	144	12	detected	detect	VBN
cord-007689-0vpp3xdl	144	13	by	by	IN
cord-007689-0vpp3xdl	144	14	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	144	15	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	144	16	of	of	IN
cord-007689-0vpp3xdl	144	17	detection	detection	NN
cord-007689-0vpp3xdl	144	18	.	.	.
cord-007689-0vpp3xdl	145	1	Only	only	RB
cord-007689-0vpp3xdl	145	2	if	if	IN
cord-007689-0vpp3xdl	145	3	the	the	DT
cord-007689-0vpp3xdl	145	4	cell	cell	NN
cord-007689-0vpp3xdl	145	5	is	be	VBZ
cord-007689-0vpp3xdl	145	6	lysed	lyse	VBN
cord-007689-0vpp3xdl	145	7	can	can	MD
cord-007689-0vpp3xdl	145	8	mitochondrial	mitochondrial	VB
cord-007689-0vpp3xdl	145	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	145	10	enter	enter	VB
cord-007689-0vpp3xdl	145	11	the	the	DT
cord-007689-0vpp3xdl	145	12	endosomal	endosomal	NNP
cord-007689-0vpp3xdl	145	13	compartment	compartment	NN
cord-007689-0vpp3xdl	145	14	of	of	IN
cord-007689-0vpp3xdl	145	15	immune	immune	JJ
cord-007689-0vpp3xdl	145	16	cells	cell	NNS
cord-007689-0vpp3xdl	145	17	via	via	IN
cord-007689-0vpp3xdl	145	18	phagocytosis	phagocytosis	NN
cord-007689-0vpp3xdl	145	19	.	.	.
cord-007689-0vpp3xdl	146	1	Indeed	indeed	RB
cord-007689-0vpp3xdl	146	2	,	,	,
cord-007689-0vpp3xdl	146	3	the	the	DT
cord-007689-0vpp3xdl	146	4	stimulatory	stimulatory	JJ
cord-007689-0vpp3xdl	146	5	effect	effect	NN
cord-007689-0vpp3xdl	146	6	of	of	IN
cord-007689-0vpp3xdl	146	7	in	in	FW
cord-007689-0vpp3xdl	146	8	vitro	vitro	FW
cord-007689-0vpp3xdl	146	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	146	10	transcripts	transcript	NNS
cord-007689-0vpp3xdl	146	11	composed	compose	VBN
cord-007689-0vpp3xdl	146	12	of	of	IN
cord-007689-0vpp3xdl	146	13	unmodified	unmodified	JJ
cord-007689-0vpp3xdl	146	14	nucleotides	nucleotide	NNS
cord-007689-0vpp3xdl	146	15	in	in	IN
cord-007689-0vpp3xdl	146	16	their	-PRON-	PRP$
cord-007689-0vpp3xdl	146	17	study	study	NN
cord-007689-0vpp3xdl	146	18	could	could	MD
cord-007689-0vpp3xdl	146	19	be	be	VB
cord-007689-0vpp3xdl	146	20	abrogated	abrogate	VBN
cord-007689-0vpp3xdl	146	21	by	by	IN
cord-007689-0vpp3xdl	146	22	incorporation	incorporation	NN
cord-007689-0vpp3xdl	146	23	of	of	IN
cord-007689-0vpp3xdl	146	24	modified	modify	VBN
cord-007689-0vpp3xdl	146	25	nucleosides	nucleoside	NNS
cord-007689-0vpp3xdl	146	26	such	such	JJ
cord-007689-0vpp3xdl	146	27	as	as	IN
cord-007689-0vpp3xdl	146	28	pseudouridine	pseudouridine	NN
cord-007689-0vpp3xdl	146	29	,	,	,
cord-007689-0vpp3xdl	146	30	5-methylcytidine	5-methylcytidine	CD
cord-007689-0vpp3xdl	146	31	,	,	,
cord-007689-0vpp3xdl	146	32	N6-methyladenosine	N6-methyladenosine	NNP
cord-007689-0vpp3xdl	146	33	,	,	,
cord-007689-0vpp3xdl	146	34	inosine	inosine	JJ
cord-007689-0vpp3xdl	146	35	,	,	,
cord-007689-0vpp3xdl	146	36	and	and	CC
cord-007689-0vpp3xdl	146	37	N7methylguanosine	N7methylguanosine	NNP
cord-007689-0vpp3xdl	146	38	.	.	.
cord-007689-0vpp3xdl	147	1	In	in	IN
cord-007689-0vpp3xdl	147	2	order	order	NN
cord-007689-0vpp3xdl	147	3	to	to	TO
cord-007689-0vpp3xdl	147	4	examine	examine	VB
cord-007689-0vpp3xdl	147	5	modification	modification	NN
cord-007689-0vpp3xdl	147	6	sensitivity	sensitivity	NN
cord-007689-0vpp3xdl	147	7	of	of	IN
cord-007689-0vpp3xdl	147	8	different	different	JJ
cord-007689-0vpp3xdl	147	9	TLRs	tlr	NNS
cord-007689-0vpp3xdl	147	10	,	,	,
cord-007689-0vpp3xdl	147	11	HEK293	HEK293	NNP
cord-007689-0vpp3xdl	147	12	cells	cell	NNS
cord-007689-0vpp3xdl	147	13	expressing	express	VBG
cord-007689-0vpp3xdl	147	14	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	147	15	,	,	,
cord-007689-0vpp3xdl	147	16	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	147	17	,	,	,
cord-007689-0vpp3xdl	147	18	TLR8	TLR8	NNP
cord-007689-0vpp3xdl	147	19	,	,	,
cord-007689-0vpp3xdl	147	20	or	or	CC
cord-007689-0vpp3xdl	147	21	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	147	22	were	be	VBD
cord-007689-0vpp3xdl	147	23	transfected	transfecte	VBN
cord-007689-0vpp3xdl	147	24	with	with	IN
cord-007689-0vpp3xdl	147	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	147	26	containing	contain	VBG
cord-007689-0vpp3xdl	147	27	modified	modify	VBN
cord-007689-0vpp3xdl	147	28	nucleosides	nucleoside	NNS
cord-007689-0vpp3xdl	147	29	.	.	.
cord-007689-0vpp3xdl	148	1	Transfection	transfection	NN
cord-007689-0vpp3xdl	148	2	of	of	IN
cord-007689-0vpp3xdl	148	3	unmodified	unmodified	JJ
cord-007689-0vpp3xdl	148	4	RNAs	rna	NNS
cord-007689-0vpp3xdl	148	5	stimulated	stimulate	VBD
cord-007689-0vpp3xdl	148	6	IL-8	il-8	NN
cord-007689-0vpp3xdl	148	7	production	production	NN
cord-007689-0vpp3xdl	148	8	(	(	-LRB-
cord-007689-0vpp3xdl	148	9	sensitive	sensitive	JJ
cord-007689-0vpp3xdl	148	10	readout	readout	NN
cord-007689-0vpp3xdl	148	11	for	for	IN
cord-007689-0vpp3xdl	148	12	immunoactivation	immunoactivation	NN
cord-007689-0vpp3xdl	148	13	of	of	IN
cord-007689-0vpp3xdl	148	14	HEK293	HEK293	NNP
cord-007689-0vpp3xdl	148	15	cells	cell	NNS
cord-007689-0vpp3xdl	148	16	)	)	-RRB-
cord-007689-0vpp3xdl	148	17	in	in	IN
cord-007689-0vpp3xdl	148	18	HEK293	HEK293	NNP
cord-007689-0vpp3xdl	148	19	cells	cell	NNS
cord-007689-0vpp3xdl	148	20	overexpressing	overexpresse	VBG
cord-007689-0vpp3xdl	148	21	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	148	22	,	,	,
cord-007689-0vpp3xdl	148	23	7	7	CD
cord-007689-0vpp3xdl	148	24	,	,	,
cord-007689-0vpp3xdl	148	25	and	and	CC
cord-007689-0vpp3xdl	148	26	8	8	CD
cord-007689-0vpp3xdl	148	27	.	.	.
cord-007689-0vpp3xdl	149	1	Interestingly	interestingly	RB
cord-007689-0vpp3xdl	149	2	,	,	,
cord-007689-0vpp3xdl	149	3	RNA	RNA	NNP
cord-007689-0vpp3xdl	149	4	recognition	recognition	NN
cord-007689-0vpp3xdl	149	5	by	by	IN
cord-007689-0vpp3xdl	149	6	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	149	7	,	,	,
cord-007689-0vpp3xdl	149	8	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	149	9	,	,	,
cord-007689-0vpp3xdl	149	10	and	and	CC
cord-007689-0vpp3xdl	149	11	TLR8	TLR8	NNP
cord-007689-0vpp3xdl	149	12	is	be	VBZ
cord-007689-0vpp3xdl	149	13	suppressed	suppress	VBN
cord-007689-0vpp3xdl	149	14	by	by	IN
cord-007689-0vpp3xdl	149	15	the	the	DT
cord-007689-0vpp3xdl	149	16	presence	presence	NN
cord-007689-0vpp3xdl	149	17	of	of	IN
cord-007689-0vpp3xdl	149	18	different	different	JJ
cord-007689-0vpp3xdl	149	19	types	type	NNS
cord-007689-0vpp3xdl	149	20	of	of	IN
cord-007689-0vpp3xdl	149	21	modified	modify	VBN
cord-007689-0vpp3xdl	149	22	nucleotides	nucleotide	NNS
cord-007689-0vpp3xdl	149	23	within	within	IN
cord-007689-0vpp3xdl	149	24	the	the	DT
cord-007689-0vpp3xdl	149	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	149	26	ligand	ligand	NN
cord-007689-0vpp3xdl	149	27	.	.	.
cord-007689-0vpp3xdl	150	1	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	150	2	was	be	VBD
cord-007689-0vpp3xdl	150	3	the	the	DT
cord-007689-0vpp3xdl	150	4	least	least	JJS
cord-007689-0vpp3xdl	150	5	sensitive	sensitive	JJ
cord-007689-0vpp3xdl	150	6	receptor	receptor	NN
cord-007689-0vpp3xdl	150	7	with	with	IN
cord-007689-0vpp3xdl	150	8	regard	regard	NN
cord-007689-0vpp3xdl	150	9	to	to	IN
cord-007689-0vpp3xdl	150	10	suppression	suppression	NN
cord-007689-0vpp3xdl	150	11	by	by	IN
cord-007689-0vpp3xdl	150	12	nucleoside	nucleoside	JJ
cord-007689-0vpp3xdl	150	13	modifications	modification	NNS
cord-007689-0vpp3xdl	150	14	.	.	.
cord-007689-0vpp3xdl	151	1	Furthermore	furthermore	RB
cord-007689-0vpp3xdl	151	2	,	,	,
cord-007689-0vpp3xdl	151	3	the	the	DT
cord-007689-0vpp3xdl	151	4	authors	author	NNS
cord-007689-0vpp3xdl	151	5	showed	show	VBD
cord-007689-0vpp3xdl	151	6	that	that	IN
cord-007689-0vpp3xdl	151	7	in	in	IN
cord-007689-0vpp3xdl	151	8	monocyte	monocyte	NNP
cord-007689-0vpp3xdl	151	9	-	-	HYPH
cord-007689-0vpp3xdl	151	10	derived	derive	VBN
cord-007689-0vpp3xdl	151	11	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	151	12	cells	cell	NNS
cord-007689-0vpp3xdl	151	13	,	,	,
cord-007689-0vpp3xdl	151	14	5%-10	5%-10	CD
cord-007689-0vpp3xdl	151	15	%	%	NN
cord-007689-0vpp3xdl	151	16	of	of	IN
cord-007689-0vpp3xdl	151	17	modified	modify	VBN
cord-007689-0vpp3xdl	151	18	nucleosides	nucleoside	NNS
cord-007689-0vpp3xdl	151	19	were	be	VBD
cord-007689-0vpp3xdl	151	20	sufficient	sufficient	JJ
cord-007689-0vpp3xdl	151	21	to	to	TO
cord-007689-0vpp3xdl	151	22	inhibit	inhibit	VB
cord-007689-0vpp3xdl	151	23	TNF	TNF	NNP
cord-007689-0vpp3xdl	151	24	-	-	HYPH
cord-007689-0vpp3xdl	151	25	α	α	VBG
cord-007689-0vpp3xdl	151	26	secretion	secretion	NN
cord-007689-0vpp3xdl	151	27	by	by	IN
cord-007689-0vpp3xdl	151	28	75%-90	75%-90	CD
cord-007689-0vpp3xdl	151	29	%	%	NN
cord-007689-0vpp3xdl	151	30	.	.	.
cord-007689-0vpp3xdl	152	1	Together	together	RB
cord-007689-0vpp3xdl	152	2	,	,	,
cord-007689-0vpp3xdl	152	3	these	these	DT
cord-007689-0vpp3xdl	152	4	results	result	NNS
cord-007689-0vpp3xdl	152	5	show	show	VBP
cord-007689-0vpp3xdl	152	6	that	that	IN
cord-007689-0vpp3xdl	152	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	152	8	modification	modification	NN
cord-007689-0vpp3xdl	152	9	contributes	contribute	VBZ
cord-007689-0vpp3xdl	152	10	to	to	IN
cord-007689-0vpp3xdl	152	11	the	the	DT
cord-007689-0vpp3xdl	152	12	distinction	distinction	NN
cord-007689-0vpp3xdl	152	13	of	of	IN
cord-007689-0vpp3xdl	152	14	self	self	NN
cord-007689-0vpp3xdl	152	15	versus	versus	IN
cord-007689-0vpp3xdl	152	16	non	non	JJ
cord-007689-0vpp3xdl	152	17	-	-	JJ
cord-007689-0vpp3xdl	152	18	self	self	JJ
cord-007689-0vpp3xdl	152	19	RNA	RNA	NNP
cord-007689-0vpp3xdl	152	20	by	by	IN
cord-007689-0vpp3xdl	152	21	the	the	DT
cord-007689-0vpp3xdl	152	22	immune	immune	JJ
cord-007689-0vpp3xdl	152	23	system	system	NN
cord-007689-0vpp3xdl	152	24	.	.	.
cord-007689-0vpp3xdl	153	1	Further	further	JJ
cord-007689-0vpp3xdl	153	2	insight	insight	NN
cord-007689-0vpp3xdl	153	3	into	into	IN
cord-007689-0vpp3xdl	153	4	the	the	DT
cord-007689-0vpp3xdl	153	5	properties	property	NNS
cord-007689-0vpp3xdl	153	6	that	that	WDT
cord-007689-0vpp3xdl	153	7	render	render	VBP
cord-007689-0vpp3xdl	153	8	RNA	rna	NN
cord-007689-0vpp3xdl	153	9	molecules	molecule	NNS
cord-007689-0vpp3xdl	153	10	stimulatory	stimulatory	JJ
cord-007689-0vpp3xdl	153	11	to	to	IN
cord-007689-0vpp3xdl	153	12	the	the	DT
cord-007689-0vpp3xdl	153	13	immune	immune	JJ
cord-007689-0vpp3xdl	153	14	system	system	NN
cord-007689-0vpp3xdl	153	15	is	be	VBZ
cord-007689-0vpp3xdl	153	16	driven	drive	VBN
cord-007689-0vpp3xdl	153	17	by	by	IN
cord-007689-0vpp3xdl	153	18	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	153	19	technology	technology	NN
cord-007689-0vpp3xdl	153	20	.	.	.
cord-007689-0vpp3xdl	154	1	Based	base	VBN
cord-007689-0vpp3xdl	154	2	on	on	IN
cord-007689-0vpp3xdl	154	3	studies	study	NNS
cord-007689-0vpp3xdl	154	4	by	by	IN
cord-007689-0vpp3xdl	154	5	Tuschl	Tuschl	NNP
cord-007689-0vpp3xdl	154	6	and	and	CC
cord-007689-0vpp3xdl	154	7	colleagues	colleague	NNS
cord-007689-0vpp3xdl	155	1	(	(	-LRB-
cord-007689-0vpp3xdl	155	2	Elbashir	Elbashir	NNP
cord-007689-0vpp3xdl	155	3	et	et	FW
cord-007689-0vpp3xdl	155	4	al	al	NNP
cord-007689-0vpp3xdl	155	5	.	.	NNP
cord-007689-0vpp3xdl	155	6	2001	2001	CD
cord-007689-0vpp3xdl	155	7	)	)	-RRB-
cord-007689-0vpp3xdl	155	8	,	,	,
cord-007689-0vpp3xdl	155	9	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	155	10	is	be	VBZ
cord-007689-0vpp3xdl	155	11	now	now	RB
cord-007689-0vpp3xdl	155	12	used	use	VBN
cord-007689-0vpp3xdl	155	13	worldwide	worldwide	RB
cord-007689-0vpp3xdl	155	14	as	as	IN
cord-007689-0vpp3xdl	155	15	a	a	DT
cord-007689-0vpp3xdl	155	16	robust	robust	JJ
cord-007689-0vpp3xdl	155	17	tool	tool	NN
cord-007689-0vpp3xdl	155	18	for	for	IN
cord-007689-0vpp3xdl	155	19	target	target	NN
cord-007689-0vpp3xdl	155	20	-	-	HYPH
cord-007689-0vpp3xdl	155	21	specific	specific	JJ
cord-007689-0vpp3xdl	155	22	gene	gene	NN
cord-007689-0vpp3xdl	155	23	silencing	silence	VBG
cord-007689-0vpp3xdl	155	24	in	in	IN
cord-007689-0vpp3xdl	155	25	cell	cell	NN
cord-007689-0vpp3xdl	155	26	lines	line	NNS
cord-007689-0vpp3xdl	155	27	and	and	CC
cord-007689-0vpp3xdl	155	28	human	human	JJ
cord-007689-0vpp3xdl	155	29	primary	primary	JJ
cord-007689-0vpp3xdl	155	30	cells	cell	NNS
cord-007689-0vpp3xdl	155	31	.	.	.
cord-007689-0vpp3xdl	156	1	However	however	RB
cord-007689-0vpp3xdl	156	2	,	,	,
cord-007689-0vpp3xdl	156	3	depending	depend	VBG
cord-007689-0vpp3xdl	156	4	on	on	IN
cord-007689-0vpp3xdl	156	5	the	the	DT
cord-007689-0vpp3xdl	156	6	mode	mode	NN
cord-007689-0vpp3xdl	156	7	of	of	IN
cord-007689-0vpp3xdl	156	8	synthesis	synthesis	NN
cord-007689-0vpp3xdl	156	9	and	and	CC
cord-007689-0vpp3xdl	156	10	the	the	DT
cord-007689-0vpp3xdl	156	11	sequences	sequence	NNS
cord-007689-0vpp3xdl	156	12	used	use	VBD
cord-007689-0vpp3xdl	156	13	to	to	TO
cord-007689-0vpp3xdl	156	14	generate	generate	VB
cord-007689-0vpp3xdl	156	15	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	156	16	,	,	,
cord-007689-0vpp3xdl	156	17	also	also	RB
cord-007689-0vpp3xdl	156	18	nonspecific	nonspecific	JJ
cord-007689-0vpp3xdl	156	19	,	,	,
cord-007689-0vpp3xdl	156	20	so	so	RB
cord-007689-0vpp3xdl	156	21	-	-	HYPH
cord-007689-0vpp3xdl	156	22	called	call	VBN
cord-007689-0vpp3xdl	156	23	nonspecific	nonspecific	JJ
cord-007689-0vpp3xdl	156	24	off	off	IN
cord-007689-0vpp3xdl	156	25	-	-	HYPH
cord-007689-0vpp3xdl	156	26	target	target	NN
cord-007689-0vpp3xdl	156	27	effects	effect	NNS
cord-007689-0vpp3xdl	156	28	of	of	IN
cord-007689-0vpp3xdl	156	29	siRNAs	sirna	NNS
cord-007689-0vpp3xdl	156	30	were	be	VBD
cord-007689-0vpp3xdl	156	31	observed	observe	VBN
cord-007689-0vpp3xdl	156	32	.	.	.
cord-007689-0vpp3xdl	157	1	To	to	TO
cord-007689-0vpp3xdl	157	2	overcome	overcome	VB
cord-007689-0vpp3xdl	157	3	limitations	limitation	NNS
cord-007689-0vpp3xdl	157	4	with	with	IN
cord-007689-0vpp3xdl	157	5	the	the	DT
cord-007689-0vpp3xdl	157	6	transfection	transfection	NN
cord-007689-0vpp3xdl	157	7	of	of	IN
cord-007689-0vpp3xdl	157	8	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	157	9	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	157	10	,	,	,
cord-007689-0vpp3xdl	157	11	vectorbased	vectorbased	NNP
cord-007689-0vpp3xdl	157	12	(	(	-LRB-
cord-007689-0vpp3xdl	157	13	e.g.	e.g.	RB
cord-007689-0vpp3xdl	157	14	,	,	,
cord-007689-0vpp3xdl	157	15	lentiviral	lentiviral	JJ
cord-007689-0vpp3xdl	157	16	)	)	-RRB-
cord-007689-0vpp3xdl	157	17	expression	expression	NN
cord-007689-0vpp3xdl	157	18	systems	system	NNS
cord-007689-0vpp3xdl	157	19	for	for	IN
cord-007689-0vpp3xdl	157	20	the	the	DT
cord-007689-0vpp3xdl	157	21	introduction	introduction	NN
cord-007689-0vpp3xdl	157	22	of	of	IN
cord-007689-0vpp3xdl	157	23	short	short	JJ
cord-007689-0vpp3xdl	157	24	hairpin	hairpin	NN
cord-007689-0vpp3xdl	157	25	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	157	26	(	(	-LRB-
cord-007689-0vpp3xdl	157	27	shRNA	shrna	NN
cord-007689-0vpp3xdl	157	28	)	)	-RRB-
cord-007689-0vpp3xdl	157	29	mimicking	mimic	VBG
cord-007689-0vpp3xdl	157	30	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	157	31	were	be	VBD
cord-007689-0vpp3xdl	157	32	developed	develop	VBN
cord-007689-0vpp3xdl	158	1	(	(	-LRB-
cord-007689-0vpp3xdl	158	2	Brummelkamp	Brummelkamp	NNP
cord-007689-0vpp3xdl	158	3	et	et	NNP
cord-007689-0vpp3xdl	158	4	al	al	NNP
cord-007689-0vpp3xdl	158	5	.	.	.
cord-007689-0vpp3xdl	159	1	2002	2002	CD
cord-007689-0vpp3xdl	159	2	;	;	:
cord-007689-0vpp3xdl	159	3	Harborth	Harborth	NNP
cord-007689-0vpp3xdl	159	4	et	et	NNP
cord-007689-0vpp3xdl	159	5	al	al	NNP
cord-007689-0vpp3xdl	159	6	.	.	.
cord-007689-0vpp3xdl	160	1	2003	2003	CD
cord-007689-0vpp3xdl	160	2	;	;	:
cord-007689-0vpp3xdl	160	3	Paddison	Paddison	NNP
cord-007689-0vpp3xdl	160	4	et	et	NNP
cord-007689-0vpp3xdl	160	5	al	al	NNP
cord-007689-0vpp3xdl	160	6	.	.	.
cord-007689-0vpp3xdl	160	7	2002	2002	CD
cord-007689-0vpp3xdl	160	8	)	)	-RRB-
cord-007689-0vpp3xdl	160	9	.	.	.
cord-007689-0vpp3xdl	161	1	The	the	DT
cord-007689-0vpp3xdl	161	2	most	most	RBS
cord-007689-0vpp3xdl	161	3	commonly	commonly	RB
cord-007689-0vpp3xdl	161	4	used	use	VBN
cord-007689-0vpp3xdl	161	5	shRNA	shrna	NN
cord-007689-0vpp3xdl	161	6	expression	expression	NN
cord-007689-0vpp3xdl	161	7	system	system	NN
cord-007689-0vpp3xdl	161	8	consists	consist	VBZ
cord-007689-0vpp3xdl	161	9	of	of	IN
cord-007689-0vpp3xdl	161	10	a	a	DT
cord-007689-0vpp3xdl	161	11	RNA	rna	NN
cord-007689-0vpp3xdl	161	12	-	-	HYPH
cord-007689-0vpp3xdl	161	13	polymerase	polymerase	NN
cord-007689-0vpp3xdl	161	14	III	iii	CD
cord-007689-0vpp3xdl	161	15	dependent	dependent	JJ
cord-007689-0vpp3xdl	161	16	promoter	promoter	NN
cord-007689-0vpp3xdl	161	17	driving	drive	VBG
cord-007689-0vpp3xdl	161	18	the	the	DT
cord-007689-0vpp3xdl	161	19	expression	expression	NN
cord-007689-0vpp3xdl	161	20	of	of	IN
cord-007689-0vpp3xdl	161	21	two	two	CD
cord-007689-0vpp3xdl	161	22	complementary	complementary	JJ
cord-007689-0vpp3xdl	161	23	19-to	19-to	CD
cord-007689-0vpp3xdl	162	1	29-bp	29-bp	CD
cord-007689-0vpp3xdl	162	2	RNA	RNA	NNP
cord-007689-0vpp3xdl	162	3	sequences	sequence	NNS
cord-007689-0vpp3xdl	162	4	linked	link	VBN
cord-007689-0vpp3xdl	162	5	by	by	IN
cord-007689-0vpp3xdl	162	6	a	a	DT
cord-007689-0vpp3xdl	162	7	short	short	JJ
cord-007689-0vpp3xdl	162	8	loop	loop	NN
cord-007689-0vpp3xdl	162	9	of	of	IN
cord-007689-0vpp3xdl	162	10	4	4	CD
cord-007689-0vpp3xdl	162	11	-	-	SYM
cord-007689-0vpp3xdl	162	12	10	10	CD
cord-007689-0vpp3xdl	162	13	nt	nt	RB
cord-007689-0vpp3xdl	162	14	.	.	.
cord-007689-0vpp3xdl	163	1	The	the	DT
cord-007689-0vpp3xdl	163	2	resulting	result	VBG
cord-007689-0vpp3xdl	163	3	transcript	transcript	NN
cord-007689-0vpp3xdl	163	4	is	be	VBZ
cord-007689-0vpp3xdl	163	5	exported	export	VBN
cord-007689-0vpp3xdl	163	6	to	to	IN
cord-007689-0vpp3xdl	163	7	the	the	DT
cord-007689-0vpp3xdl	163	8	cytoplasm	cytoplasm	NN
cord-007689-0vpp3xdl	163	9	and	and	CC
cord-007689-0vpp3xdl	163	10	processed	process	VBN
cord-007689-0vpp3xdl	163	11	by	by	IN
cord-007689-0vpp3xdl	163	12	dicer	dicer	NN
cord-007689-0vpp3xdl	163	13	.	.	.
cord-007689-0vpp3xdl	164	1	Lentiviral	Lentiviral	NNP
cord-007689-0vpp3xdl	164	2	vectors	vector	NNS
cord-007689-0vpp3xdl	164	3	haboring	habore	VBG
cord-007689-0vpp3xdl	164	4	the	the	DT
cord-007689-0vpp3xdl	164	5	Pol	Pol	NNP
cord-007689-0vpp3xdl	164	6	III	III	NNP
cord-007689-0vpp3xdl	164	7	-	-	HYPH
cord-007689-0vpp3xdl	164	8	shRNA	shrna	NN
cord-007689-0vpp3xdl	164	9	expression	expression	NN
cord-007689-0vpp3xdl	164	10	cassette	cassette	NN
cord-007689-0vpp3xdl	164	11	(	(	-LRB-
cord-007689-0vpp3xdl	164	12	Li	Li	NNP
cord-007689-0vpp3xdl	164	13	et	et	NNP
cord-007689-0vpp3xdl	164	14	al	al	NNP
cord-007689-0vpp3xdl	164	15	.	.	.
cord-007689-0vpp3xdl	164	16	2003	2003	CD
cord-007689-0vpp3xdl	165	1	;	;	:
cord-007689-0vpp3xdl	165	2	Rubinson	Rubinson	NNP
cord-007689-0vpp3xdl	165	3	et	et	NNP
cord-007689-0vpp3xdl	165	4	al	al	NNP
cord-007689-0vpp3xdl	165	5	.	.	.
cord-007689-0vpp3xdl	166	1	2003	2003	CD
cord-007689-0vpp3xdl	166	2	;	;	:
cord-007689-0vpp3xdl	166	3	Tiscornia	Tiscornia	NNP
cord-007689-0vpp3xdl	166	4	et	et	NNP
cord-007689-0vpp3xdl	166	5	al	al	NNP
cord-007689-0vpp3xdl	166	6	.	.	NNP
cord-007689-0vpp3xdl	166	7	2003	2003	CD
cord-007689-0vpp3xdl	166	8	)	)	-RRB-
cord-007689-0vpp3xdl	166	9	allow	allow	VBP
cord-007689-0vpp3xdl	166	10	RNAi	RNAi	NNP
cord-007689-0vpp3xdl	166	11	-	-	HYPH
cord-007689-0vpp3xdl	166	12	mediated	mediate	VBN
cord-007689-0vpp3xdl	166	13	gene	gene	NN
cord-007689-0vpp3xdl	166	14	silencing	silencing	NN
cord-007689-0vpp3xdl	166	15	via	via	IN
cord-007689-0vpp3xdl	166	16	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	166	17	in	in	IN
cord-007689-0vpp3xdl	166	18	cells	cell	NNS
cord-007689-0vpp3xdl	166	19	that	that	WDT
cord-007689-0vpp3xdl	166	20	are	be	VBP
cord-007689-0vpp3xdl	166	21	otherwise	otherwise	RB
cord-007689-0vpp3xdl	166	22	difficult	difficult	JJ
cord-007689-0vpp3xdl	166	23	to	to	TO
cord-007689-0vpp3xdl	166	24	transfect	transfect	VB
cord-007689-0vpp3xdl	166	25	.	.	.
cord-007689-0vpp3xdl	167	1	Sequence	sequence	NN
cord-007689-0vpp3xdl	167	2	specificity	specificity	NN
cord-007689-0vpp3xdl	167	3	of	of	IN
cord-007689-0vpp3xdl	167	4	gene	gene	NN
cord-007689-0vpp3xdl	167	5	silencing	silencing	NN
cord-007689-0vpp3xdl	167	6	by	by	IN
cord-007689-0vpp3xdl	167	7	such	such	JJ
cord-007689-0vpp3xdl	167	8	shRNA	shrna	NN
cord-007689-0vpp3xdl	167	9	was	be	VBD
cord-007689-0vpp3xdl	167	10	questioned	question	VBN
cord-007689-0vpp3xdl	167	11	by	by	IN
cord-007689-0vpp3xdl	167	12	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	167	13	et	et	NNP
cord-007689-0vpp3xdl	167	14	al	al	NNP
cord-007689-0vpp3xdl	167	15	.	.	.
cord-007689-0vpp3xdl	168	1	(	(	-LRB-
cord-007689-0vpp3xdl	168	2	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	168	3	et	et	NNP
cord-007689-0vpp3xdl	168	4	al	al	NNP
cord-007689-0vpp3xdl	168	5	.	.	NNP
cord-007689-0vpp3xdl	168	6	2003	2003	CD
cord-007689-0vpp3xdl	168	7	)	)	-RRB-
cord-007689-0vpp3xdl	168	8	,	,	,
cord-007689-0vpp3xdl	168	9	who	who	WP
cord-007689-0vpp3xdl	168	10	demonstrated	demonstrate	VBD
cord-007689-0vpp3xdl	168	11	that	that	IN
cord-007689-0vpp3xdl	168	12	infection	infection	NN
cord-007689-0vpp3xdl	168	13	of	of	IN
cord-007689-0vpp3xdl	168	14	human	human	JJ
cord-007689-0vpp3xdl	168	15	lung	lung	NN
cord-007689-0vpp3xdl	168	16	fibroblasts	fibroblast	NNS
cord-007689-0vpp3xdl	168	17	with	with	IN
cord-007689-0vpp3xdl	168	18	Pol	Pol	NNP
cord-007689-0vpp3xdl	168	19	III	III	NNP
cord-007689-0vpp3xdl	168	20	-	-	HYPH
cord-007689-0vpp3xdl	168	21	shRNA	shrna	NN
cord-007689-0vpp3xdl	168	22	containing	contain	VBG
cord-007689-0vpp3xdl	168	23	lentivirus	lentivirus	NN
cord-007689-0vpp3xdl	168	24	directed	direct	VBN
cord-007689-0vpp3xdl	168	25	against	against	IN
cord-007689-0vpp3xdl	168	26	the	the	DT
cord-007689-0vpp3xdl	168	27	gene	gene	NN
cord-007689-0vpp3xdl	168	28	MORF4L1	MORF4L1	NNP
cord-007689-0vpp3xdl	168	29	not	not	RB
cord-007689-0vpp3xdl	168	30	only	only	RB
cord-007689-0vpp3xdl	168	31	silenced	silence	VBD
cord-007689-0vpp3xdl	168	32	MORF4L1	MORF4L1	NNP
cord-007689-0vpp3xdl	168	33	but	but	CC
cord-007689-0vpp3xdl	168	34	also	also	RB
cord-007689-0vpp3xdl	168	35	stimulated	stimulate	VBD
cord-007689-0vpp3xdl	168	36	interferoninducible	interferoninducible	JJ
cord-007689-0vpp3xdl	168	37	genes	gene	NNS
cord-007689-0vpp3xdl	168	38	such	such	JJ
cord-007689-0vpp3xdl	168	39	as	as	IN
cord-007689-0vpp3xdl	168	40	2′,5′-OAS	2′,5′-oas	CD
cord-007689-0vpp3xdl	168	41	,	,	,
cord-007689-0vpp3xdl	168	42	an	an	DT
cord-007689-0vpp3xdl	168	43	indicator	indicator	NN
cord-007689-0vpp3xdl	168	44	of	of	IN
cord-007689-0vpp3xdl	168	45	type	type	NN
cord-007689-0vpp3xdl	168	46	I	-PRON-	PRP
cord-007689-0vpp3xdl	168	47	interferon	interferon	VBD
cord-007689-0vpp3xdl	168	48	.	.	.
cord-007689-0vpp3xdl	169	1	The	the	DT
cord-007689-0vpp3xdl	169	2	IFNinducing	ifninducing	NN
cord-007689-0vpp3xdl	169	3	effect	effect	NN
cord-007689-0vpp3xdl	169	4	was	be	VBD
cord-007689-0vpp3xdl	169	5	dependent	dependent	JJ
cord-007689-0vpp3xdl	169	6	on	on	IN
cord-007689-0vpp3xdl	169	7	the	the	DT
cord-007689-0vpp3xdl	169	8	sequence	sequence	NN
cord-007689-0vpp3xdl	169	9	and	and	CC
cord-007689-0vpp3xdl	169	10	the	the	DT
cord-007689-0vpp3xdl	169	11	dose	dose	NN
cord-007689-0vpp3xdl	169	12	of	of	IN
cord-007689-0vpp3xdl	169	13	the	the	DT
cord-007689-0vpp3xdl	169	14	vector	vector	NN
cord-007689-0vpp3xdl	169	15	;	;	:
cord-007689-0vpp3xdl	169	16	seven	seven	CD
cord-007689-0vpp3xdl	169	17	of	of	IN
cord-007689-0vpp3xdl	169	18	23	23	CD
cord-007689-0vpp3xdl	169	19	shRNAs	shRNAs	NNP
cord-007689-0vpp3xdl	169	20	targeting	target	VBG
cord-007689-0vpp3xdl	169	21	different	different	JJ
cord-007689-0vpp3xdl	169	22	genes	gene	NNS
cord-007689-0vpp3xdl	169	23	exhibited	exhibit	VBD
cord-007689-0vpp3xdl	169	24	IFN	IFN	NNP
cord-007689-0vpp3xdl	169	25	induction	induction	NN
cord-007689-0vpp3xdl	169	26	.	.	.
cord-007689-0vpp3xdl	170	1	In	in	IN
cord-007689-0vpp3xdl	170	2	contrast	contrast	NN
cord-007689-0vpp3xdl	170	3	,	,	,
cord-007689-0vpp3xdl	170	4	transfection	transfection	NN
cord-007689-0vpp3xdl	170	5	of	of	IN
cord-007689-0vpp3xdl	170	6	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	170	7	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	170	8	with	with	IN
cord-007689-0vpp3xdl	170	9	the	the	DT
cord-007689-0vpp3xdl	170	10	same	same	JJ
cord-007689-0vpp3xdl	170	11	putative	putative	JJ
cord-007689-0vpp3xdl	170	12	IFN	IFN	NNP
cord-007689-0vpp3xdl	170	13	-	-	HYPH
cord-007689-0vpp3xdl	170	14	inducing	induce	VBG
cord-007689-0vpp3xdl	170	15	sequences	sequence	NNS
cord-007689-0vpp3xdl	170	16	led	lead	VBD
cord-007689-0vpp3xdl	170	17	to	to	IN
cord-007689-0vpp3xdl	170	18	sequence	sequence	NN
cord-007689-0vpp3xdl	170	19	-	-	HYPH
cord-007689-0vpp3xdl	170	20	specific	specific	JJ
cord-007689-0vpp3xdl	170	21	silencing	silencing	NN
cord-007689-0vpp3xdl	170	22	without	without	IN
cord-007689-0vpp3xdl	170	23	triggering	trigger	VBG
cord-007689-0vpp3xdl	170	24	an	an	DT
cord-007689-0vpp3xdl	170	25	IFN	IFN	NNP
cord-007689-0vpp3xdl	170	26	response	response	NN
cord-007689-0vpp3xdl	170	27	.	.	.
cord-007689-0vpp3xdl	171	1	Northern	northern	JJ
cord-007689-0vpp3xdl	171	2	blot	blot	NN
cord-007689-0vpp3xdl	171	3	analysis	analysis	NN
cord-007689-0vpp3xdl	171	4	of	of	IN
cord-007689-0vpp3xdl	171	5	shRNA	shrna	NN
cord-007689-0vpp3xdl	171	6	showed	show	VBD
cord-007689-0vpp3xdl	171	7	that	that	IN
cord-007689-0vpp3xdl	171	8	the	the	DT
cord-007689-0vpp3xdl	171	9	majority	majority	NN
cord-007689-0vpp3xdl	171	10	of	of	IN
cord-007689-0vpp3xdl	171	11	shRNA	shrna	CD
cord-007689-0vpp3xdl	171	12	transcripts	transcript	NNS
cord-007689-0vpp3xdl	171	13	were	be	VBD
cord-007689-0vpp3xdl	171	14	correctly	correctly	RB
cord-007689-0vpp3xdl	171	15	processed	process	VBN
cord-007689-0vpp3xdl	171	16	to	to	IN
cord-007689-0vpp3xdl	171	17	20	20	CD
cord-007689-0vpp3xdl	171	18	nt	nt	NNP
cord-007689-0vpp3xdl	171	19	transcripts	transcript	NNS
cord-007689-0vpp3xdl	171	20	.	.	.
cord-007689-0vpp3xdl	172	1	The	the	DT
cord-007689-0vpp3xdl	172	2	authors	author	NNS
cord-007689-0vpp3xdl	172	3	speculated	speculate	VBD
cord-007689-0vpp3xdl	172	4	that	that	IN
cord-007689-0vpp3xdl	172	5	remaining	remain	VBG
cord-007689-0vpp3xdl	172	6	unprocessed	unprocessed	JJ
cord-007689-0vpp3xdl	172	7	transcripts	transcript	NNS
cord-007689-0vpp3xdl	172	8	could	could	MD
cord-007689-0vpp3xdl	172	9	be	be	VB
cord-007689-0vpp3xdl	172	10	detected	detect	VBN
cord-007689-0vpp3xdl	172	11	by	by	IN
cord-007689-0vpp3xdl	172	12	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	172	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	172	14	sensing	sensing	NN
cord-007689-0vpp3xdl	172	15	receptors	receptor	NNS
cord-007689-0vpp3xdl	172	16	.	.	.
cord-007689-0vpp3xdl	173	1	In	in	IN
cord-007689-0vpp3xdl	173	2	the	the	DT
cord-007689-0vpp3xdl	173	3	follow	follow	NN
cord-007689-0vpp3xdl	173	4	-	-	HYPH
cord-007689-0vpp3xdl	173	5	up	up	NN
cord-007689-0vpp3xdl	173	6	paper	paper	NN
cord-007689-0vpp3xdl	173	7	,	,	,
cord-007689-0vpp3xdl	173	8	the	the	DT
cord-007689-0vpp3xdl	173	9	group	group	NN
cord-007689-0vpp3xdl	173	10	of	of	IN
cord-007689-0vpp3xdl	173	11	Iggo	Iggo	NNP
cord-007689-0vpp3xdl	173	12	(	(	-LRB-
cord-007689-0vpp3xdl	173	13	Pebernard	Pebernard	NNP
cord-007689-0vpp3xdl	173	14	and	and	CC
cord-007689-0vpp3xdl	173	15	Iggo	Iggo	NNP
cord-007689-0vpp3xdl	173	16	2004	2004	CD
cord-007689-0vpp3xdl	173	17	)	)	-RRB-
cord-007689-0vpp3xdl	173	18	,	,	,
cord-007689-0vpp3xdl	173	19	further	further	RB
cord-007689-0vpp3xdl	173	20	correlated	correlate	VBD
cord-007689-0vpp3xdl	173	21	the	the	DT
cord-007689-0vpp3xdl	173	22	U6	U6	NNP
cord-007689-0vpp3xdl	173	23	promoter	promoter	NN
cord-007689-0vpp3xdl	173	24	sequence	sequence	NN
cord-007689-0vpp3xdl	173	25	with	with	IN
cord-007689-0vpp3xdl	173	26	OAS	OAS	NNP
cord-007689-0vpp3xdl	173	27	induction	induction	NN
cord-007689-0vpp3xdl	173	28	.	.	.
cord-007689-0vpp3xdl	174	1	This	this	DT
cord-007689-0vpp3xdl	174	2	study	study	NN
cord-007689-0vpp3xdl	174	3	revealed	reveal	VBD
cord-007689-0vpp3xdl	174	4	that	that	IN
cord-007689-0vpp3xdl	174	5	the	the	DT
cord-007689-0vpp3xdl	174	6	region	region	NN
cord-007689-0vpp3xdl	174	7	between	between	IN
cord-007689-0vpp3xdl	174	8	-2	-2	NNP
cord-007689-0vpp3xdl	174	9	(	(	-LRB-
cord-007689-0vpp3xdl	174	10	the	the	DT
cord-007689-0vpp3xdl	174	11	end	end	NN
cord-007689-0vpp3xdl	174	12	of	of	IN
cord-007689-0vpp3xdl	174	13	the	the	DT
cord-007689-0vpp3xdl	174	14	promoter	promoter	NN
cord-007689-0vpp3xdl	174	15	)	)	-RRB-
cord-007689-0vpp3xdl	174	16	and	and	CC
cord-007689-0vpp3xdl	174	17	+2	+2	LS
cord-007689-0vpp3xdl	174	18	(	(	-LRB-
cord-007689-0vpp3xdl	174	19	the	the	DT
cord-007689-0vpp3xdl	174	20	start	start	NN
cord-007689-0vpp3xdl	174	21	of	of	IN
cord-007689-0vpp3xdl	174	22	RNA	RNA	NNP
cord-007689-0vpp3xdl	174	23	transcript	transcript	NN
cord-007689-0vpp3xdl	174	24	)	)	-RRB-
cord-007689-0vpp3xdl	174	25	is	be	VBZ
cord-007689-0vpp3xdl	174	26	crucial	crucial	JJ
cord-007689-0vpp3xdl	174	27	for	for	IN
cord-007689-0vpp3xdl	174	28	the	the	DT
cord-007689-0vpp3xdl	174	29	immune	immune	JJ
cord-007689-0vpp3xdl	174	30	stimulatory	stimulatory	JJ
cord-007689-0vpp3xdl	174	31	effect	effect	NN
cord-007689-0vpp3xdl	174	32	,	,	,
cord-007689-0vpp3xdl	174	33	which	which	WDT
cord-007689-0vpp3xdl	174	34	was	be	VBD
cord-007689-0vpp3xdl	174	35	lost	lose	VBN
cord-007689-0vpp3xdl	174	36	when	when	WRB
cord-007689-0vpp3xdl	174	37	they	-PRON-	PRP
cord-007689-0vpp3xdl	174	38	used	use	VBD
cord-007689-0vpp3xdl	174	39	the	the	DT
cord-007689-0vpp3xdl	174	40	endogenous	endogenous	JJ
cord-007689-0vpp3xdl	174	41	human	human	JJ
cord-007689-0vpp3xdl	174	42	sequence	sequence	NN
cord-007689-0vpp3xdl	174	43	(	(	-LRB-
cord-007689-0vpp3xdl	174	44	CCGA	CCGA	NNP
cord-007689-0vpp3xdl	174	45	)	)	-RRB-
cord-007689-0vpp3xdl	174	46	.	.	.
cord-007689-0vpp3xdl	175	1	Further	further	JJ
cord-007689-0vpp3xdl	175	2	mutations	mutation	NNS
cord-007689-0vpp3xdl	175	3	leading	lead	VBG
cord-007689-0vpp3xdl	175	4	to	to	IN
cord-007689-0vpp3xdl	175	5	a	a	DT
cord-007689-0vpp3xdl	175	6	partial	partial	JJ
cord-007689-0vpp3xdl	175	7	mismatch	mismatch	NN
cord-007689-0vpp3xdl	175	8	in	in	IN
cord-007689-0vpp3xdl	175	9	the	the	DT
cord-007689-0vpp3xdl	175	10	shRNA	shrna	NN
cord-007689-0vpp3xdl	175	11	(	(	-LRB-
cord-007689-0vpp3xdl	175	12	predicted	predict	VBN
cord-007689-0vpp3xdl	175	13	to	to	TO
cord-007689-0vpp3xdl	175	14	create	create	VB
cord-007689-0vpp3xdl	175	15	a	a	DT
cord-007689-0vpp3xdl	175	16	14-bp	14-bp	CD
cord-007689-0vpp3xdl	175	17	duplex	duplex	NN
cord-007689-0vpp3xdl	175	18	)	)	-RRB-
cord-007689-0vpp3xdl	175	19	suggested	suggest	VBD
cord-007689-0vpp3xdl	175	20	that	that	IN
cord-007689-0vpp3xdl	175	21	stimulation	stimulation	NN
cord-007689-0vpp3xdl	175	22	required	require	VBD
cord-007689-0vpp3xdl	175	23	more	more	RBR
cord-007689-0vpp3xdl	175	24	than	than	IN
cord-007689-0vpp3xdl	175	25	a	a	DT
cord-007689-0vpp3xdl	175	26	14-bp	14-bp	CD
cord-007689-0vpp3xdl	175	27	duplex	duplex	NN
cord-007689-0vpp3xdl	175	28	.	.	.
cord-007689-0vpp3xdl	176	1	William´s	william´s	JJ
cord-007689-0vpp3xdl	176	2	group	group	NN
cord-007689-0vpp3xdl	176	3	(	(	-LRB-
cord-007689-0vpp3xdl	176	4	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	176	5	et	et	NNP
cord-007689-0vpp3xdl	176	6	al	al	NNP
cord-007689-0vpp3xdl	176	7	.	.	NNP
cord-007689-0vpp3xdl	176	8	2003	2003	CD
cord-007689-0vpp3xdl	176	9	)	)	-RRB-
cord-007689-0vpp3xdl	176	10	described	describe	VBD
cord-007689-0vpp3xdl	176	11	the	the	DT
cord-007689-0vpp3xdl	176	12	induction	induction	NN
cord-007689-0vpp3xdl	176	13	of	of	IN
cord-007689-0vpp3xdl	176	14	IFN	IFN	NNP
cord-007689-0vpp3xdl	176	15	target	target	NN
cord-007689-0vpp3xdl	176	16	genes	gene	NNS
cord-007689-0vpp3xdl	176	17	by	by	IN
cord-007689-0vpp3xdl	176	18	transfection	transfection	NN
cord-007689-0vpp3xdl	176	19	of	of	IN
cord-007689-0vpp3xdl	176	20	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	176	21	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	176	22	into	into	IN
cord-007689-0vpp3xdl	176	23	a	a	DT
cord-007689-0vpp3xdl	176	24	human	human	JJ
cord-007689-0vpp3xdl	176	25	glioblastoma	glioblastoma	NN
cord-007689-0vpp3xdl	176	26	cell	cell	NN
cord-007689-0vpp3xdl	176	27	line	line	NN
cord-007689-0vpp3xdl	176	28	(	(	-LRB-
cord-007689-0vpp3xdl	176	29	T98	T98	NNP
cord-007689-0vpp3xdl	176	30	G	G	NNP
cord-007689-0vpp3xdl	176	31	)	)	-RRB-
cord-007689-0vpp3xdl	176	32	or	or	CC
cord-007689-0vpp3xdl	176	33	a	a	DT
cord-007689-0vpp3xdl	176	34	renal	renal	JJ
cord-007689-0vpp3xdl	176	35	carcinoma	carcinoma	NN
cord-007689-0vpp3xdl	176	36	cell	cell	NN
cord-007689-0vpp3xdl	176	37	line	line	NN
cord-007689-0vpp3xdl	176	38	(	(	-LRB-
cord-007689-0vpp3xdl	176	39	RCC	RCC	NNP
cord-007689-0vpp3xdl	176	40	)	)	-RRB-
cord-007689-0vpp3xdl	176	41	.	.	.
cord-007689-0vpp3xdl	177	1	When	when	WRB
cord-007689-0vpp3xdl	177	2	comparing	compare	VBG
cord-007689-0vpp3xdl	177	3	the	the	DT
cord-007689-0vpp3xdl	177	4	two	two	CD
cord-007689-0vpp3xdl	177	5	studies	study	NNS
cord-007689-0vpp3xdl	177	6	from	from	IN
cord-007689-0vpp3xdl	177	7	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	177	8	and	and	CC
cord-007689-0vpp3xdl	177	9	colleagues	colleague	NNS
cord-007689-0vpp3xdl	177	10	and	and	CC
cord-007689-0vpp3xdl	177	11	from	from	IN
cord-007689-0vpp3xdl	177	12	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	177	13	and	and	CC
cord-007689-0vpp3xdl	177	14	colleagues	colleague	NNS
cord-007689-0vpp3xdl	177	15	,	,	,
cord-007689-0vpp3xdl	177	16	it	-PRON-	PRP
cord-007689-0vpp3xdl	177	17	is	be	VBZ
cord-007689-0vpp3xdl	177	18	important	important	JJ
cord-007689-0vpp3xdl	177	19	to	to	TO
cord-007689-0vpp3xdl	177	20	note	note	VB
cord-007689-0vpp3xdl	177	21	that	that	IN
cord-007689-0vpp3xdl	177	22	different	different	JJ
cord-007689-0vpp3xdl	177	23	cell	cell	NN
cord-007689-0vpp3xdl	177	24	lines	line	NNS
cord-007689-0vpp3xdl	177	25	(	(	-LRB-
cord-007689-0vpp3xdl	177	26	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	177	27	,	,	,
cord-007689-0vpp3xdl	177	28	human	human	JJ
cord-007689-0vpp3xdl	177	29	lung	lung	NN
cord-007689-0vpp3xdl	177	30	fibroblasts	fibroblast	NNS
cord-007689-0vpp3xdl	177	31	;	;	:
cord-007689-0vpp3xdl	177	32	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	177	33	,	,	,
cord-007689-0vpp3xdl	177	34	RCC	RCC	NNP
cord-007689-0vpp3xdl	177	35	and	and	CC
cord-007689-0vpp3xdl	177	36	T98	T98	NNP
cord-007689-0vpp3xdl	177	37	G	G	NNP
cord-007689-0vpp3xdl	177	38	)	)	-RRB-
cord-007689-0vpp3xdl	177	39	and	and	CC
cord-007689-0vpp3xdl	177	40	different	different	JJ
cord-007689-0vpp3xdl	177	41	ways	way	NNS
cord-007689-0vpp3xdl	177	42	of	of	IN
cord-007689-0vpp3xdl	177	43	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	177	44	generation	generation	NN
cord-007689-0vpp3xdl	177	45	(	(	-LRB-
cord-007689-0vpp3xdl	177	46	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	177	47	,	,	,
cord-007689-0vpp3xdl	177	48	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	177	49	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	177	50	and	and	CC
cord-007689-0vpp3xdl	177	51	shRNAs	shRNAs	NNP
cord-007689-0vpp3xdl	177	52	;	;	:
cord-007689-0vpp3xdl	177	53	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	177	54	,	,	,
cord-007689-0vpp3xdl	177	55	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	177	56	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	177	57	and	and	CC
cord-007689-0vpp3xdl	177	58	T7-phage	t7-phage	NN
cord-007689-0vpp3xdl	177	59	-	-	HYPH
cord-007689-0vpp3xdl	177	60	polymerase	polymerase	NN
cord-007689-0vpp3xdl	177	61	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	177	62	)	)	-RRB-
cord-007689-0vpp3xdl	177	63	were	be	VBD
cord-007689-0vpp3xdl	177	64	used	use	VBN
cord-007689-0vpp3xdl	177	65	.	.	.
cord-007689-0vpp3xdl	178	1	Using	use	VBG
cord-007689-0vpp3xdl	178	2	mouse	mouse	NN
cord-007689-0vpp3xdl	178	3	embryonic	embryonic	JJ
cord-007689-0vpp3xdl	178	4	fibroblasts	fibroblast	NNS
cord-007689-0vpp3xdl	178	5	(	(	-LRB-
cord-007689-0vpp3xdl	178	6	MEFs	MEFs	NNP
cord-007689-0vpp3xdl	178	7	)	)	-RRB-
cord-007689-0vpp3xdl	178	8	with	with	IN
cord-007689-0vpp3xdl	178	9	different	different	JJ
cord-007689-0vpp3xdl	178	10	gene	gene	NN
cord-007689-0vpp3xdl	178	11	deficiencies	deficiency	NNS
cord-007689-0vpp3xdl	178	12	related	relate	VBN
cord-007689-0vpp3xdl	178	13	to	to	IN
cord-007689-0vpp3xdl	178	14	the	the	DT
cord-007689-0vpp3xdl	178	15	IFN	IFN	NNP
cord-007689-0vpp3xdl	178	16	response	response	NN
cord-007689-0vpp3xdl	178	17	system	system	NN
cord-007689-0vpp3xdl	178	18	,	,	,
cord-007689-0vpp3xdl	178	19	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	178	20	et	et	NNP
cord-007689-0vpp3xdl	178	21	al	al	NNP
cord-007689-0vpp3xdl	178	22	.	.	NNP
cord-007689-0vpp3xdl	178	23	proposed	propose	VBD
cord-007689-0vpp3xdl	178	24	that	that	IN
cord-007689-0vpp3xdl	178	25	PKR	PKR	NNP
cord-007689-0vpp3xdl	178	26	was	be	VBD
cord-007689-0vpp3xdl	178	27	the	the	DT
cord-007689-0vpp3xdl	178	28	interferon	interferon	NN
cord-007689-0vpp3xdl	178	29	-	-	HYPH
cord-007689-0vpp3xdl	178	30	inducing	induce	VBG
cord-007689-0vpp3xdl	178	31	receptor	receptor	NN
cord-007689-0vpp3xdl	178	32	for	for	IN
cord-007689-0vpp3xdl	178	33	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	178	34	.	.	.
cord-007689-0vpp3xdl	179	1	Later	later	RBR
cord-007689-0vpp3xdl	179	2	,	,	,
cord-007689-0vpp3xdl	179	3	the	the	DT
cord-007689-0vpp3xdl	179	4	same	same	JJ
cord-007689-0vpp3xdl	179	5	group	group	NN
cord-007689-0vpp3xdl	179	6	postulated	postulate	VBD
cord-007689-0vpp3xdl	179	7	a	a	DT
cord-007689-0vpp3xdl	179	8	different	different	JJ
cord-007689-0vpp3xdl	179	9	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	179	10	receptor	receptor	NN
cord-007689-0vpp3xdl	179	11	(	(	-LRB-
cord-007689-0vpp3xdl	179	12	RIG	rig	NN
cord-007689-0vpp3xdl	179	13	-	-	:
cord-007689-0vpp3xdl	179	14	I	-PRON-	PRP
cord-007689-0vpp3xdl	179	15	,	,	,
cord-007689-0vpp3xdl	179	16	see	see	VB
cord-007689-0vpp3xdl	179	17	below	below	RB
cord-007689-0vpp3xdl	179	18	)	)	-RRB-
cord-007689-0vpp3xdl	179	19	in	in	IN
cord-007689-0vpp3xdl	179	20	T98	T98	NNP
cord-007689-0vpp3xdl	179	21	G	G	NNP
cord-007689-0vpp3xdl	179	22	cells	cell	NNS
cord-007689-0vpp3xdl	179	23	(	(	-LRB-
cord-007689-0vpp3xdl	179	24	Marques	Marques	NNP
cord-007689-0vpp3xdl	179	25	et	et	NNP
cord-007689-0vpp3xdl	179	26	al	al	NNP
cord-007689-0vpp3xdl	179	27	.	.	.
cord-007689-0vpp3xdl	179	28	2006	2006	CD
cord-007689-0vpp3xdl	179	29	)	)	-RRB-
cord-007689-0vpp3xdl	179	30	.	.	.
cord-007689-0vpp3xdl	180	1	Of	of	IN
cord-007689-0vpp3xdl	180	2	note	note	VB
cord-007689-0vpp3xdl	180	3	,	,	,
cord-007689-0vpp3xdl	180	4	in	in	IN
cord-007689-0vpp3xdl	180	5	the	the	DT
cord-007689-0vpp3xdl	180	6	two	two	CD
cord-007689-0vpp3xdl	180	7	studies	study	NNS
cord-007689-0vpp3xdl	180	8	published	publish	VBN
cord-007689-0vpp3xdl	180	9	by	by	IN
cord-007689-0vpp3xdl	180	10	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	180	11	et	et	NNP
cord-007689-0vpp3xdl	180	12	al	al	NNP
cord-007689-0vpp3xdl	180	13	.	.	.
cord-007689-0vpp3xdl	181	1	(	(	-LRB-
cord-007689-0vpp3xdl	181	2	2003	2003	CD
cord-007689-0vpp3xdl	181	3	)	)	-RRB-
cord-007689-0vpp3xdl	181	4	and	and	CC
cord-007689-0vpp3xdl	181	5	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	181	6	et	et	NNP
cord-007689-0vpp3xdl	181	7	al	al	NNP
cord-007689-0vpp3xdl	181	8	.	.	.
cord-007689-0vpp3xdl	182	1	(	(	-LRB-
cord-007689-0vpp3xdl	182	2	2003	2003	CD
cord-007689-0vpp3xdl	182	3	)	)	-RRB-
cord-007689-0vpp3xdl	182	4	,	,	,
cord-007689-0vpp3xdl	182	5	type	type	NN
cord-007689-0vpp3xdl	182	6	I	-PRON-	PRP
cord-007689-0vpp3xdl	182	7	interferon	interferon	NN
cord-007689-0vpp3xdl	182	8	was	be	VBD
cord-007689-0vpp3xdl	182	9	not	not	RB
cord-007689-0vpp3xdl	182	10	analyzed	analyze	VBN
cord-007689-0vpp3xdl	182	11	at	at	IN
cord-007689-0vpp3xdl	182	12	the	the	DT
cord-007689-0vpp3xdl	182	13	protein	protein	NN
cord-007689-0vpp3xdl	182	14	level	level	NN
cord-007689-0vpp3xdl	182	15	.	.	.
cord-007689-0vpp3xdl	183	1	Kariko	Kariko	NNP
cord-007689-0vpp3xdl	183	2	et	et	FW
cord-007689-0vpp3xdl	183	3	al	al	NNP
cord-007689-0vpp3xdl	183	4	.	.	.
cord-007689-0vpp3xdl	184	1	(	(	-LRB-
cord-007689-0vpp3xdl	184	2	2004a	2004a	CD
cord-007689-0vpp3xdl	184	3	)	)	-RRB-
cord-007689-0vpp3xdl	184	4	suggested	suggest	VBD
cord-007689-0vpp3xdl	184	5	that	that	IN
cord-007689-0vpp3xdl	184	6	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	184	7	was	be	VBD
cord-007689-0vpp3xdl	184	8	responsible	responsible	JJ
cord-007689-0vpp3xdl	184	9	for	for	IN
cord-007689-0vpp3xdl	184	10	the	the	DT
cord-007689-0vpp3xdl	184	11	induction	induction	NN
cord-007689-0vpp3xdl	184	12	of	of	IN
cord-007689-0vpp3xdl	184	13	type	type	NN
cord-007689-0vpp3xdl	185	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	185	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	185	3	by	by	IN
cord-007689-0vpp3xdl	185	4	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	185	5	.	.	.
cord-007689-0vpp3xdl	186	1	These	these	DT
cord-007689-0vpp3xdl	186	2	data	datum	NNS
cord-007689-0vpp3xdl	186	3	are	be	VBP
cord-007689-0vpp3xdl	186	4	based	base	VBN
cord-007689-0vpp3xdl	186	5	on	on	IN
cord-007689-0vpp3xdl	186	6	keratinocyte	keratinocyte	NNP
cord-007689-0vpp3xdl	186	7	(	(	-LRB-
cord-007689-0vpp3xdl	186	8	HaCaT	HaCaT	NNP
cord-007689-0vpp3xdl	186	9	)	)	-RRB-
cord-007689-0vpp3xdl	186	10	and	and	CC
cord-007689-0vpp3xdl	186	11	HEK	HEK	NNP
cord-007689-0vpp3xdl	186	12	293	293	CD
cord-007689-0vpp3xdl	186	13	cells	cell	NNS
cord-007689-0vpp3xdl	186	14	,	,	,
cord-007689-0vpp3xdl	186	15	which	which	WDT
cord-007689-0vpp3xdl	186	16	responded	respond	VBD
cord-007689-0vpp3xdl	186	17	to	to	IN
cord-007689-0vpp3xdl	186	18	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	186	19	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	186	20	but	but	CC
cord-007689-0vpp3xdl	186	21	not	not	RB
cord-007689-0vpp3xdl	186	22	to	to	IN
cord-007689-0vpp3xdl	186	23	the	the	DT
cord-007689-0vpp3xdl	186	24	singlestranded	singlestrande	VBN
cord-007689-0vpp3xdl	186	25	components	component	NNS
cord-007689-0vpp3xdl	186	26	(	(	-LRB-
cord-007689-0vpp3xdl	186	27	ssRNA	ssrna	NN
cord-007689-0vpp3xdl	186	28	)	)	-RRB-
cord-007689-0vpp3xdl	186	29	by	by	IN
cord-007689-0vpp3xdl	186	30	secretion	secretion	NN
cord-007689-0vpp3xdl	186	31	of	of	IN
cord-007689-0vpp3xdl	186	32	low	low	JJ
cord-007689-0vpp3xdl	186	33	amounts	amount	NNS
cord-007689-0vpp3xdl	186	34	of	of	IN
cord-007689-0vpp3xdl	186	35	IFN	IFN	NNP
cord-007689-0vpp3xdl	186	36	-	-	HYPH
cord-007689-0vpp3xdl	186	37	β	β	NNP
cord-007689-0vpp3xdl	186	38	that	that	WDT
cord-007689-0vpp3xdl	186	39	was	be	VBD
cord-007689-0vpp3xdl	186	40	comparable	comparable	JJ
cord-007689-0vpp3xdl	186	41	to	to	IN
cord-007689-0vpp3xdl	186	42	stimulation	stimulation	NN
cord-007689-0vpp3xdl	186	43	with	with	IN
cord-007689-0vpp3xdl	186	44	poly	poly	NN
cord-007689-0vpp3xdl	187	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	187	2	:	:	:
cord-007689-0vpp3xdl	188	1	C.	C.	NNP
cord-007689-0vpp3xdl	188	2	Overexpression	Overexpression	NNP
cord-007689-0vpp3xdl	188	3	of	of	IN
cord-007689-0vpp3xdl	188	4	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	188	5	in	in	IN
cord-007689-0vpp3xdl	188	6	HEK	HEK	NNP
cord-007689-0vpp3xdl	188	7	293	293	CD
cord-007689-0vpp3xdl	188	8	cells	cell	NNS
cord-007689-0vpp3xdl	188	9	resulted	result	VBD
cord-007689-0vpp3xdl	188	10	in	in	IN
cord-007689-0vpp3xdl	188	11	fourfold	fourfold	JJ
cord-007689-0vpp3xdl	188	12	higher	high	JJR
cord-007689-0vpp3xdl	188	13	induction	induction	NN
cord-007689-0vpp3xdl	188	14	of	of	IN
cord-007689-0vpp3xdl	188	15	type	type	NN
cord-007689-0vpp3xdl	189	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	189	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	189	3	secretion	secretion	NN
cord-007689-0vpp3xdl	189	4	in	in	IN
cord-007689-0vpp3xdl	189	5	response	response	NN
cord-007689-0vpp3xdl	189	6	to	to	IN
cord-007689-0vpp3xdl	189	7	transfected	transfecte	VBN
cord-007689-0vpp3xdl	189	8	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	189	9	.	.	.
cord-007689-0vpp3xdl	190	1	However	however	RB
cord-007689-0vpp3xdl	190	2	,	,	,
cord-007689-0vpp3xdl	190	3	overexpression	overexpression	NN
cord-007689-0vpp3xdl	190	4	of	of	IN
cord-007689-0vpp3xdl	190	5	NF	nf	NN
cord-007689-0vpp3xdl	190	6	-	-	HYPH
cord-007689-0vpp3xdl	190	7	κB	κB	NNP
cord-007689-0vpp3xdl	190	8	-	-	HYPH
cord-007689-0vpp3xdl	190	9	inducing	induce	VBG
cord-007689-0vpp3xdl	190	10	receptors	receptor	NNS
cord-007689-0vpp3xdl	190	11	such	such	JJ
cord-007689-0vpp3xdl	190	12	as	as	IN
cord-007689-0vpp3xdl	190	13	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	190	14	may	may	MD
cord-007689-0vpp3xdl	190	15	also	also	RB
cord-007689-0vpp3xdl	190	16	contribute	contribute	VB
cord-007689-0vpp3xdl	190	17	indirectly	indirectly	RB
cord-007689-0vpp3xdl	190	18	to	to	IN
cord-007689-0vpp3xdl	190	19	the	the	DT
cord-007689-0vpp3xdl	190	20	enhanced	enhanced	JJ
cord-007689-0vpp3xdl	190	21	type	type	NN
cord-007689-0vpp3xdl	191	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	191	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	191	3	response	response	NN
cord-007689-0vpp3xdl	191	4	induced	induce	VBN
cord-007689-0vpp3xdl	191	5	by	by	IN
cord-007689-0vpp3xdl	191	6	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	191	7	,	,	,
cord-007689-0vpp3xdl	191	8	for	for	IN
cord-007689-0vpp3xdl	191	9	example	example	NN
cord-007689-0vpp3xdl	191	10	by	by	IN
cord-007689-0vpp3xdl	191	11	upregulating	upregulate	VBG
cord-007689-0vpp3xdl	191	12	IFN	IFN	NNP
cord-007689-0vpp3xdl	191	13	-	-	HYPH
cord-007689-0vpp3xdl	191	14	inducible	inducible	JJ
cord-007689-0vpp3xdl	191	15	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	191	16	RNA	RNA	NNP
cord-007689-0vpp3xdl	191	17	receptors	receptor	NNS
cord-007689-0vpp3xdl	191	18	.	.	.
cord-007689-0vpp3xdl	192	1	For	for	IN
cord-007689-0vpp3xdl	192	2	example	example	NN
cord-007689-0vpp3xdl	192	3	,	,	,
cord-007689-0vpp3xdl	192	4	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	192	5	overexpressing	overexpresse	VBG
cord-007689-0vpp3xdl	192	6	HEK	HEK	NNP
cord-007689-0vpp3xdl	192	7	293	293	CD
cord-007689-0vpp3xdl	192	8	cells	cell	NNS
cord-007689-0vpp3xdl	192	9	secrete	secrete	VBP
cord-007689-0vpp3xdl	192	10	more	more	JJR
cord-007689-0vpp3xdl	192	11	IL-8	il-8	NN
cord-007689-0vpp3xdl	192	12	than	than	IN
cord-007689-0vpp3xdl	192	13	empty	empty	JJ
cord-007689-0vpp3xdl	192	14	vector	vector	NN
cord-007689-0vpp3xdl	192	15	or	or	CC
cord-007689-0vpp3xdl	192	16	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	192	17	overexpressing	overexpresse	VBG
cord-007689-0vpp3xdl	192	18	HEK	HEK	NNP
cord-007689-0vpp3xdl	192	19	293	293	CD
cord-007689-0vpp3xdl	192	20	cells	cell	NNS
cord-007689-0vpp3xdl	192	21	(	(	-LRB-
cord-007689-0vpp3xdl	192	22	Kariko	Kariko	NNP
cord-007689-0vpp3xdl	192	23	et	et	FW
cord-007689-0vpp3xdl	192	24	al	al	NNP
cord-007689-0vpp3xdl	192	25	.	.	NNP
cord-007689-0vpp3xdl	192	26	2005	2005	CD
cord-007689-0vpp3xdl	192	27	)	)	-RRB-
cord-007689-0vpp3xdl	192	28	;	;	:
cord-007689-0vpp3xdl	192	29	consequently	consequently	RB
cord-007689-0vpp3xdl	192	30	,	,	,
cord-007689-0vpp3xdl	192	31	such	such	JJ
cord-007689-0vpp3xdl	192	32	studies	study	NNS
cord-007689-0vpp3xdl	192	33	do	do	VBP
cord-007689-0vpp3xdl	192	34	not	not	RB
cord-007689-0vpp3xdl	192	35	necessarily	necessarily	RB
cord-007689-0vpp3xdl	192	36	provide	provide	VB
cord-007689-0vpp3xdl	192	37	evidence	evidence	NN
cord-007689-0vpp3xdl	192	38	for	for	IN
cord-007689-0vpp3xdl	192	39	a	a	DT
cord-007689-0vpp3xdl	192	40	direct	direct	JJ
cord-007689-0vpp3xdl	192	41	interaction	interaction	NN
cord-007689-0vpp3xdl	192	42	between	between	IN
cord-007689-0vpp3xdl	192	43	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	192	44	and	and	CC
cord-007689-0vpp3xdl	192	45	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	192	46	.	.	.
cord-007689-0vpp3xdl	193	1	Kim	Kim	NNP
cord-007689-0vpp3xdl	193	2	et	et	NNP
cord-007689-0vpp3xdl	193	3	al	al	NNP
cord-007689-0vpp3xdl	193	4	.	.	.
cord-007689-0vpp3xdl	194	1	(	(	-LRB-
cord-007689-0vpp3xdl	194	2	2004	2004	CD
cord-007689-0vpp3xdl	194	3	)	)	-RRB-
cord-007689-0vpp3xdl	194	4	showed	show	VBD
cord-007689-0vpp3xdl	194	5	that	that	IN
cord-007689-0vpp3xdl	194	6	the	the	DT
cord-007689-0vpp3xdl	194	7	induction	induction	NN
cord-007689-0vpp3xdl	194	8	of	of	IN
cord-007689-0vpp3xdl	194	9	type	type	NN
cord-007689-0vpp3xdl	195	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	195	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	195	3	by	by	IN
cord-007689-0vpp3xdl	195	4	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	195	5	depended	depend	VBD
cord-007689-0vpp3xdl	195	6	on	on	IN
cord-007689-0vpp3xdl	195	7	the	the	DT
cord-007689-0vpp3xdl	195	8	use	use	NN
cord-007689-0vpp3xdl	195	9	of	of	IN
cord-007689-0vpp3xdl	195	10	T7-RNA	T7-RNA	NNP
cord-007689-0vpp3xdl	195	11	polymerase	polymerase	NN
cord-007689-0vpp3xdl	195	12	(	(	-LRB-
cord-007689-0vpp3xdl	195	13	T7	T7	NNP
cord-007689-0vpp3xdl	195	14	RNAP	RNAP	NNP
cord-007689-0vpp3xdl	195	15	)	)	-RRB-
cord-007689-0vpp3xdl	195	16	for	for	IN
cord-007689-0vpp3xdl	195	17	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	195	18	generation	generation	NN
cord-007689-0vpp3xdl	195	19	.	.	.
cord-007689-0vpp3xdl	196	1	In	in	IN
cord-007689-0vpp3xdl	196	2	contrast	contrast	NN
cord-007689-0vpp3xdl	196	3	to	to	IN
cord-007689-0vpp3xdl	196	4	Bridge	Bridge	NNP
cord-007689-0vpp3xdl	196	5	et	et	FW
cord-007689-0vpp3xdl	196	6	al	al	NNP
cord-007689-0vpp3xdl	196	7	.	.	.
cord-007689-0vpp3xdl	197	1	(	(	-LRB-
cord-007689-0vpp3xdl	197	2	2003	2003	CD
cord-007689-0vpp3xdl	197	3	)	)	-RRB-
cord-007689-0vpp3xdl	197	4	and	and	CC
cord-007689-0vpp3xdl	197	5	Sledz	Sledz	NNP
cord-007689-0vpp3xdl	197	6	et	et	NNP
cord-007689-0vpp3xdl	197	7	al	al	NNP
cord-007689-0vpp3xdl	197	8	.	.	.
cord-007689-0vpp3xdl	198	1	(	(	-LRB-
cord-007689-0vpp3xdl	198	2	2003	2003	CD
cord-007689-0vpp3xdl	198	3	)	)	-RRB-
cord-007689-0vpp3xdl	198	4	,	,	,
cord-007689-0vpp3xdl	198	5	in	in	IN
cord-007689-0vpp3xdl	198	6	the	the	DT
cord-007689-0vpp3xdl	198	7	study	study	NN
cord-007689-0vpp3xdl	198	8	by	by	IN
cord-007689-0vpp3xdl	198	9	Kim	Kim	NNP
cord-007689-0vpp3xdl	198	10	and	and	CC
cord-007689-0vpp3xdl	198	11	colleagues	colleague	NNS
cord-007689-0vpp3xdl	198	12	,	,	,
cord-007689-0vpp3xdl	198	13	type	type	NN
cord-007689-0vpp3xdl	198	14	I	-PRON-	PRP
cord-007689-0vpp3xdl	198	15	IFN	IFN	NNP
cord-007689-0vpp3xdl	198	16	was	be	VBD
cord-007689-0vpp3xdl	198	17	measured	measure	VBN
cord-007689-0vpp3xdl	198	18	at	at	IN
cord-007689-0vpp3xdl	198	19	the	the	DT
cord-007689-0vpp3xdl	198	20	protein	protein	NN
cord-007689-0vpp3xdl	198	21	level	level	NN
cord-007689-0vpp3xdl	198	22	,	,	,
cord-007689-0vpp3xdl	198	23	which	which	WDT
cord-007689-0vpp3xdl	198	24	is	be	VBZ
cord-007689-0vpp3xdl	198	25	less	less	RBR
cord-007689-0vpp3xdl	198	26	sensitive	sensitive	JJ
cord-007689-0vpp3xdl	198	27	than	than	IN
cord-007689-0vpp3xdl	198	28	measuring	measure	VBG
cord-007689-0vpp3xdl	198	29	IFN	IFN	NNP
cord-007689-0vpp3xdl	198	30	-	-	HYPH
cord-007689-0vpp3xdl	198	31	dependent	dependent	JJ
cord-007689-0vpp3xdl	198	32	responses	response	NNS
cord-007689-0vpp3xdl	198	33	on	on	IN
cord-007689-0vpp3xdl	198	34	the	the	DT
cord-007689-0vpp3xdl	198	35	transcriptional	transcriptional	JJ
cord-007689-0vpp3xdl	198	36	level	level	NN
cord-007689-0vpp3xdl	198	37	and	and	CC
cord-007689-0vpp3xdl	198	38	thus	thus	RB
cord-007689-0vpp3xdl	198	39	underscores	underscore	VBZ
cord-007689-0vpp3xdl	198	40	the	the	DT
cord-007689-0vpp3xdl	198	41	magnitude	magnitude	NN
cord-007689-0vpp3xdl	198	42	of	of	IN
cord-007689-0vpp3xdl	198	43	the	the	DT
cord-007689-0vpp3xdl	198	44	IFN	IFN	NNP
cord-007689-0vpp3xdl	198	45	response	response	NN
cord-007689-0vpp3xdl	198	46	they	-PRON-	PRP
cord-007689-0vpp3xdl	198	47	reported	report	VBD
cord-007689-0vpp3xdl	198	48	.	.	.
cord-007689-0vpp3xdl	199	1	In	in	IN
cord-007689-0vpp3xdl	199	2	their	-PRON-	PRP$
cord-007689-0vpp3xdl	199	3	study	study	NN
cord-007689-0vpp3xdl	199	4	,	,	,
cord-007689-0vpp3xdl	199	5	Kim	Kim	NNP
cord-007689-0vpp3xdl	199	6	and	and	CC
cord-007689-0vpp3xdl	199	7	colleagues	colleague	NNS
cord-007689-0vpp3xdl	199	8	examined	examine	VBD
cord-007689-0vpp3xdl	199	9	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	199	10	targeting	target	VBG
cord-007689-0vpp3xdl	199	11	the	the	DT
cord-007689-0vpp3xdl	199	12	early	early	JJ
cord-007689-0vpp3xdl	199	13	ICP4	icp4	JJ
cord-007689-0vpp3xdl	199	14	gene	gene	NN
cord-007689-0vpp3xdl	199	15	of	of	IN
cord-007689-0vpp3xdl	199	16	HSV-1	HSV-1	NNP
cord-007689-0vpp3xdl	199	17	.	.	.
cord-007689-0vpp3xdl	200	1	Only	only	RB
cord-007689-0vpp3xdl	200	2	T7	T7	NNP
cord-007689-0vpp3xdl	200	3	RNAP	RNAP	NNP
cord-007689-0vpp3xdl	200	4	-	-	HYPH
cord-007689-0vpp3xdl	200	5	derived	derive	VBN
cord-007689-0vpp3xdl	200	6	transcripts	transcript	NNS
cord-007689-0vpp3xdl	200	7	but	but	CC
cord-007689-0vpp3xdl	200	8	not	not	RB
cord-007689-0vpp3xdl	200	9	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	200	10	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	200	11	elicited	elicit	VBD
cord-007689-0vpp3xdl	200	12	a	a	DT
cord-007689-0vpp3xdl	200	13	potent	potent	JJ
cord-007689-0vpp3xdl	200	14	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	200	15	activity	activity	NN
cord-007689-0vpp3xdl	200	16	when	when	WRB
cord-007689-0vpp3xdl	200	17	transfected	transfecte	VBN
cord-007689-0vpp3xdl	200	18	into	into	IN
cord-007689-0vpp3xdl	200	19	HEK	HEK	NNP
cord-007689-0vpp3xdl	200	20	293	293	CD
cord-007689-0vpp3xdl	200	21	cells	cell	NNS
cord-007689-0vpp3xdl	200	22	.	.	.
cord-007689-0vpp3xdl	201	1	The	the	DT
cord-007689-0vpp3xdl	201	2	same	same	JJ
cord-007689-0vpp3xdl	201	3	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	201	4	activity	activity	NN
cord-007689-0vpp3xdl	201	5	was	be	VBD
cord-007689-0vpp3xdl	201	6	observed	observe	VBN
cord-007689-0vpp3xdl	201	7	by	by	IN
cord-007689-0vpp3xdl	201	8	transfection	transfection	NN
cord-007689-0vpp3xdl	201	9	of	of	IN
cord-007689-0vpp3xdl	201	10	T7	t7	NN
cord-007689-0vpp3xdl	201	11	transcripts	transcript	NNS
cord-007689-0vpp3xdl	201	12	with	with	IN
cord-007689-0vpp3xdl	201	13	unrelated	unrelated	JJ
cord-007689-0vpp3xdl	201	14	sequences	sequence	NNS
cord-007689-0vpp3xdl	201	15	.	.	.
cord-007689-0vpp3xdl	202	1	Analysis	analysis	NN
cord-007689-0vpp3xdl	202	2	of	of	IN
cord-007689-0vpp3xdl	202	3	supernatants	supernatant	NNS
cord-007689-0vpp3xdl	202	4	revealed	reveal	VBD
cord-007689-0vpp3xdl	202	5	the	the	DT
cord-007689-0vpp3xdl	202	6	presence	presence	NN
cord-007689-0vpp3xdl	202	7	of	of	IN
cord-007689-0vpp3xdl	202	8	substantial	substantial	JJ
cord-007689-0vpp3xdl	202	9	amounts	amount	NNS
cord-007689-0vpp3xdl	202	10	of	of	IN
cord-007689-0vpp3xdl	202	11	IFN	IFN	NNP
cord-007689-0vpp3xdl	202	12	-	-	HYPH
cord-007689-0vpp3xdl	202	13	α	α	NNP
cord-007689-0vpp3xdl	202	14	and	and	CC
cord-007689-0vpp3xdl	202	15	IFN	IFN	NNP
cord-007689-0vpp3xdl	202	16	-	-	HYPH
cord-007689-0vpp3xdl	202	17	β	β	NNP
cord-007689-0vpp3xdl	202	18	protein	protein	NN
cord-007689-0vpp3xdl	202	19	.	.	.
cord-007689-0vpp3xdl	203	1	These	these	DT
cord-007689-0vpp3xdl	203	2	results	result	NNS
cord-007689-0vpp3xdl	203	3	were	be	VBD
cord-007689-0vpp3xdl	203	4	reproduced	reproduce	VBN
cord-007689-0vpp3xdl	203	5	in	in	IN
cord-007689-0vpp3xdl	203	6	HeLa	HeLa	NNP
cord-007689-0vpp3xdl	203	7	cells	cell	NNS
cord-007689-0vpp3xdl	203	8	,	,	,
cord-007689-0vpp3xdl	203	9	as	as	RB
cord-007689-0vpp3xdl	203	10	well	well	RB
cord-007689-0vpp3xdl	203	11	as	as	IN
cord-007689-0vpp3xdl	203	12	K562	k562	XX
cord-007689-0vpp3xdl	203	13	,	,	,
cord-007689-0vpp3xdl	203	14	CEM	CEM	NNP
cord-007689-0vpp3xdl	203	15	,	,	,
cord-007689-0vpp3xdl	203	16	and	and	CC
cord-007689-0vpp3xdl	203	17	Jurkat	Jurkat	NNP
cord-007689-0vpp3xdl	203	18	cells	cell	NNS
cord-007689-0vpp3xdl	203	19	.	.	.
cord-007689-0vpp3xdl	204	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	204	2	is	be	VBZ
cord-007689-0vpp3xdl	204	3	well	well	RB
cord-007689-0vpp3xdl	204	4	known	know	VBN
cord-007689-0vpp3xdl	204	5	that	that	IN
cord-007689-0vpp3xdl	204	6	unlike	unlike	IN
cord-007689-0vpp3xdl	204	7	capped	cap	VBN
cord-007689-0vpp3xdl	204	8	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	204	9	mRNA	mrna	NN
cord-007689-0vpp3xdl	204	10	,	,	,
cord-007689-0vpp3xdl	204	11	the	the	DT
cord-007689-0vpp3xdl	204	12	5′	5′	CD
cord-007689-0vpp3xdl	204	13	ends	end	NNS
cord-007689-0vpp3xdl	204	14	of	of	IN
cord-007689-0vpp3xdl	204	15	T7	T7	NNP
cord-007689-0vpp3xdl	204	16	transcripts	transcript	NNS
cord-007689-0vpp3xdl	204	17	harbor	harbor	VBP
cord-007689-0vpp3xdl	204	18	a	a	DT
cord-007689-0vpp3xdl	204	19	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	204	20	GTP	gtp	NN
cord-007689-0vpp3xdl	204	21	-	-	HYPH
cord-007689-0vpp3xdl	204	22	nucleotide	nucleotide	JJ
cord-007689-0vpp3xdl	204	23	.	.	.
cord-007689-0vpp3xdl	205	1	Treatment	treatment	NN
cord-007689-0vpp3xdl	205	2	of	of	IN
cord-007689-0vpp3xdl	205	3	T7	t7	NN
cord-007689-0vpp3xdl	205	4	transcripts	transcript	NNS
cord-007689-0vpp3xdl	205	5	with	with	IN
cord-007689-0vpp3xdl	205	6	RNase	RNase	NNP
cord-007689-0vpp3xdl	205	7	T1	T1	NNP
cord-007689-0vpp3xdl	205	8	(	(	-LRB-
cord-007689-0vpp3xdl	205	9	with	with	IN
cord-007689-0vpp3xdl	205	10	the	the	DT
cord-007689-0vpp3xdl	205	11	5′	5′	CD
cord-007689-0vpp3xdl	205	12	end	end	NN
cord-007689-0vpp3xdl	205	13	p	p	NN
cord-007689-0vpp3xdl	205	14	-	-	:
cord-007689-0vpp3xdl	205	15	GGG	GGG	NNP
cord-007689-0vpp3xdl	205	16	removed	remove	VBN
cord-007689-0vpp3xdl	205	17	,	,	,
cord-007689-0vpp3xdl	205	18	which	which	WDT
cord-007689-0vpp3xdl	205	19	was	be	VBD
cord-007689-0vpp3xdl	205	20	single	single	RB
cord-007689-0vpp3xdl	205	21	-	-	HYPH
cord-007689-0vpp3xdl	205	22	stranded	strand	VBN
cord-007689-0vpp3xdl	205	23	in	in	IN
cord-007689-0vpp3xdl	205	24	their	-PRON-	PRP$
cord-007689-0vpp3xdl	205	25	case	case	NN
cord-007689-0vpp3xdl	205	26	)	)	-RRB-
cord-007689-0vpp3xdl	205	27	and	and	CC
cord-007689-0vpp3xdl	205	28	alkaline	alkaline	JJ
cord-007689-0vpp3xdl	205	29	phosphatase	phosphatase	NN
cord-007689-0vpp3xdl	205	30	was	be	VBD
cord-007689-0vpp3xdl	205	31	sufficient	sufficient	JJ
cord-007689-0vpp3xdl	205	32	to	to	TO
cord-007689-0vpp3xdl	205	33	completely	completely	RB
cord-007689-0vpp3xdl	205	34	abrogate	abrogate	VB
cord-007689-0vpp3xdl	205	35	interferon	interferon	NN
cord-007689-0vpp3xdl	205	36	-inducing	-inducing	NN
cord-007689-0vpp3xdl	205	37	activity	activity	NN
cord-007689-0vpp3xdl	205	38	.	.	.
cord-007689-0vpp3xdl	206	1	Additional	additional	JJ
cord-007689-0vpp3xdl	206	2	experiments	experiment	NNS
cord-007689-0vpp3xdl	206	3	using	use	VBG
cord-007689-0vpp3xdl	206	4	T3	T3	NNP
cord-007689-0vpp3xdl	206	5	and	and	CC
cord-007689-0vpp3xdl	206	6	Sp6	Sp6	NNP
cord-007689-0vpp3xdl	206	7	phage	phage	NNP
cord-007689-0vpp3xdl	206	8	RNA	RNA	NNP
cord-007689-0vpp3xdl	206	9	polymerases	polymerase	NNS
cord-007689-0vpp3xdl	206	10	demonstrated	demonstrate	VBD
cord-007689-0vpp3xdl	206	11	similar	similar	JJ
cord-007689-0vpp3xdl	206	12	induction	induction	NN
cord-007689-0vpp3xdl	206	13	of	of	IN
cord-007689-0vpp3xdl	206	14	type	type	NN
cord-007689-0vpp3xdl	206	15	I	-PRON-	PRP
cord-007689-0vpp3xdl	206	16	IFN	IFN	NNP
cord-007689-0vpp3xdl	206	17	.	.	.
cord-007689-0vpp3xdl	207	1	The	the	DT
cord-007689-0vpp3xdl	207	2	examination	examination	NN
cord-007689-0vpp3xdl	207	3	of	of	IN
cord-007689-0vpp3xdl	207	4	multiple	multiple	JJ
cord-007689-0vpp3xdl	207	5	cell	cell	NN
cord-007689-0vpp3xdl	207	6	lines	line	NNS
cord-007689-0vpp3xdl	207	7	by	by	IN
cord-007689-0vpp3xdl	207	8	Kim	Kim	NNP
cord-007689-0vpp3xdl	207	9	et	et	NNP
cord-007689-0vpp3xdl	207	10	al	al	NNP
cord-007689-0vpp3xdl	207	11	.	.	.
cord-007689-0vpp3xdl	208	1	(	(	-LRB-
cord-007689-0vpp3xdl	208	2	2004	2004	CD
cord-007689-0vpp3xdl	208	3	)	)	-RRB-
cord-007689-0vpp3xdl	208	4	pointed	point	VBD
cord-007689-0vpp3xdl	208	5	to	to	IN
cord-007689-0vpp3xdl	208	6	a	a	DT
cord-007689-0vpp3xdl	208	7	powerful	powerful	JJ
cord-007689-0vpp3xdl	208	8	ubiquitously	ubiquitously	RB
cord-007689-0vpp3xdl	208	9	expressed	express	VBN
cord-007689-0vpp3xdl	208	10	sensor	sensor	NN
cord-007689-0vpp3xdl	208	11	for	for	IN
cord-007689-0vpp3xdl	208	12	short	short	JJ
cord-007689-0vpp3xdl	208	13	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	208	14	RNA	RNA	NNP
cord-007689-0vpp3xdl	208	15	.	.	.
cord-007689-0vpp3xdl	209	1	Yoneyama	Yoneyama	NNP
cord-007689-0vpp3xdl	209	2	and	and	CC
cord-007689-0vpp3xdl	209	3	colleagues	colleague	NNS
cord-007689-0vpp3xdl	209	4	identified	identify	VBD
cord-007689-0vpp3xdl	209	5	the	the	DT
cord-007689-0vpp3xdl	209	6	interferon	interferon	NN
cord-007689-0vpp3xdl	209	7	-	-	HYPH
cord-007689-0vpp3xdl	209	8	inducing	induce	VBG
cord-007689-0vpp3xdl	209	9	cytoplasmic	cytoplasmic	JJ
cord-007689-0vpp3xdl	209	10	DexD/	DexD/	NNP
cord-007689-0vpp3xdl	209	11	H	H	NNP
cord-007689-0vpp3xdl	209	12	box	box	NN
cord-007689-0vpp3xdl	209	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	209	14	helicase	helicase	NNP
cord-007689-0vpp3xdl	209	15	RIG	rig	NN
cord-007689-0vpp3xdl	209	16	-	-	:
cord-007689-0vpp3xdl	209	17	I	I	NNP
cord-007689-0vpp3xdl	209	18	,	,	,
cord-007689-0vpp3xdl	209	19	containing	contain	VBG
cord-007689-0vpp3xdl	209	20	a	a	DT
cord-007689-0vpp3xdl	209	21	caspase	caspase	JJ
cord-007689-0vpp3xdl	209	22	recruitment	recruitment	NN
cord-007689-0vpp3xdl	209	23	domain	domain	NN
cord-007689-0vpp3xdl	209	24	(	(	-LRB-
cord-007689-0vpp3xdl	209	25	CARD	card	NN
cord-007689-0vpp3xdl	209	26	)	)	-RRB-
cord-007689-0vpp3xdl	209	27	(	(	-LRB-
cord-007689-0vpp3xdl	209	28	Yoneyama	Yoneyama	NNP
cord-007689-0vpp3xdl	209	29	et	et	NNP
cord-007689-0vpp3xdl	209	30	al	al	NNP
cord-007689-0vpp3xdl	209	31	.	.	.
cord-007689-0vpp3xdl	209	32	2004	2004	CD
cord-007689-0vpp3xdl	209	33	)	)	-RRB-
cord-007689-0vpp3xdl	209	34	.	.	.
cord-007689-0vpp3xdl	210	1	Expression	expression	NN
cord-007689-0vpp3xdl	210	2	of	of	IN
cord-007689-0vpp3xdl	210	3	the	the	DT
cord-007689-0vpp3xdl	210	4	CARD	card	NN
cord-007689-0vpp3xdl	210	5	domain	domain	NN
cord-007689-0vpp3xdl	210	6	sensitized	sensitize	VBD
cord-007689-0vpp3xdl	210	7	cells	cell	NNS
cord-007689-0vpp3xdl	210	8	to	to	TO
cord-007689-0vpp3xdl	210	9	activate	activate	VB
cord-007689-0vpp3xdl	210	10	the	the	DT
cord-007689-0vpp3xdl	210	11	transcription	transcription	NN
cord-007689-0vpp3xdl	210	12	factor	factor	NN
cord-007689-0vpp3xdl	210	13	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	210	14	,	,	,
cord-007689-0vpp3xdl	210	15	leading	lead	VBG
cord-007689-0vpp3xdl	210	16	to	to	IN
cord-007689-0vpp3xdl	210	17	the	the	DT
cord-007689-0vpp3xdl	210	18	induction	induction	NN
cord-007689-0vpp3xdl	210	19	of	of	IN
cord-007689-0vpp3xdl	210	20	the	the	DT
cord-007689-0vpp3xdl	210	21	IFN	IFN	NNP
cord-007689-0vpp3xdl	210	22	-	-	HYPH
cord-007689-0vpp3xdl	210	23	β	β	NNP
cord-007689-0vpp3xdl	210	24	promoter	promoter	NN
cord-007689-0vpp3xdl	210	25	.	.	.
cord-007689-0vpp3xdl	211	1	Later	later	RB
cord-007689-0vpp3xdl	211	2	on	on	IN
cord-007689-0vpp3xdl	211	3	it	-PRON-	PRP
cord-007689-0vpp3xdl	211	4	was	be	VBD
cord-007689-0vpp3xdl	211	5	shown	show	VBN
cord-007689-0vpp3xdl	211	6	that	that	IN
cord-007689-0vpp3xdl	211	7	this	this	DT
cord-007689-0vpp3xdl	211	8	pathway	pathway	NN
cord-007689-0vpp3xdl	211	9	involves	involve	VBZ
cord-007689-0vpp3xdl	211	10	the	the	DT
cord-007689-0vpp3xdl	211	11	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	211	12	kinase	kinase	NNP
cord-007689-0vpp3xdl	211	13	TBK1	TBK1	NNP
cord-007689-0vpp3xdl	211	14	,	,	,
cord-007689-0vpp3xdl	211	15	which	which	WDT
cord-007689-0vpp3xdl	211	16	is	be	VBZ
cord-007689-0vpp3xdl	211	17	activated	activate	VBN
cord-007689-0vpp3xdl	211	18	by	by	IN
cord-007689-0vpp3xdl	211	19	the	the	DT
cord-007689-0vpp3xdl	211	20	newly	newly	RB
cord-007689-0vpp3xdl	211	21	characterized	characterize	VBN
cord-007689-0vpp3xdl	211	22	adaptor	adaptor	NN
cord-007689-0vpp3xdl	211	23	protein	protein	NN
cord-007689-0vpp3xdl	211	24	IPS-1	IPS-1	NNP
cord-007689-0vpp3xdl	211	25	,	,	,
cord-007689-0vpp3xdl	211	26	also	also	RB
cord-007689-0vpp3xdl	211	27	known	know	VBN
cord-007689-0vpp3xdl	211	28	as	as	IN
cord-007689-0vpp3xdl	211	29	Cardif	Cardif	NNP
cord-007689-0vpp3xdl	211	30	,	,	,
cord-007689-0vpp3xdl	211	31	MAVS	MAVS	NNP
cord-007689-0vpp3xdl	211	32	,	,	,
cord-007689-0vpp3xdl	211	33	or	or	CC
cord-007689-0vpp3xdl	211	34	VISA	VISA	NNP
cord-007689-0vpp3xdl	211	35	(	(	-LRB-
cord-007689-0vpp3xdl	211	36	Kawai	Kawai	NNP
cord-007689-0vpp3xdl	211	37	et	et	NNP
cord-007689-0vpp3xdl	211	38	al	al	NNP
cord-007689-0vpp3xdl	211	39	.	.	NNP
cord-007689-0vpp3xdl	211	40	2005	2005	CD
cord-007689-0vpp3xdl	211	41	;	;	:
cord-007689-0vpp3xdl	211	42	Meylan	Meylan	NNP
cord-007689-0vpp3xdl	211	43	et	et	NNP
cord-007689-0vpp3xdl	211	44	al	al	NNP
cord-007689-0vpp3xdl	211	45	.	.	NNP
cord-007689-0vpp3xdl	211	46	2005	2005	CD
cord-007689-0vpp3xdl	211	47	;	;	:
cord-007689-0vpp3xdl	211	48	Seth	Seth	NNP
cord-007689-0vpp3xdl	211	49	et	et	NNP
cord-007689-0vpp3xdl	211	50	al	al	NNP
cord-007689-0vpp3xdl	211	51	.	.	NNP
cord-007689-0vpp3xdl	211	52	2005	2005	CD
cord-007689-0vpp3xdl	211	53	;	;	:
cord-007689-0vpp3xdl	211	54	Xu	Xu	NNP
cord-007689-0vpp3xdl	211	55	et	et	NNP
cord-007689-0vpp3xdl	211	56	al	al	NNP
cord-007689-0vpp3xdl	211	57	.	.	NNP
cord-007689-0vpp3xdl	211	58	2005	2005	CD
cord-007689-0vpp3xdl	211	59	;	;	:
cord-007689-0vpp3xdl	211	60	reviewed	review	VBN
cord-007689-0vpp3xdl	211	61	in	in	IN
cord-007689-0vpp3xdl	211	62	Sen	Sen	NNP
cord-007689-0vpp3xdl	211	63	and	and	CC
cord-007689-0vpp3xdl	211	64	Sarkar	Sarkar	NNP
cord-007689-0vpp3xdl	211	65	2005	2005	CD
cord-007689-0vpp3xdl	211	66	)	)	-RRB-
cord-007689-0vpp3xdl	211	67	.	.	.
cord-007689-0vpp3xdl	212	1	In	in	IN
cord-007689-0vpp3xdl	212	2	overexpression	overexpression	NN
cord-007689-0vpp3xdl	212	3	experiments	experiment	NNS
cord-007689-0vpp3xdl	212	4	,	,	,
cord-007689-0vpp3xdl	212	5	RIG	rig	NN
cord-007689-0vpp3xdl	212	6	-	-	:
cord-007689-0vpp3xdl	212	7	I	-PRON-	PRP
cord-007689-0vpp3xdl	212	8	was	be	VBD
cord-007689-0vpp3xdl	212	9	shown	show	VBN
cord-007689-0vpp3xdl	212	10	to	to	TO
cord-007689-0vpp3xdl	212	11	bind	bind	VB
cord-007689-0vpp3xdl	212	12	poly	poly	NNP
cord-007689-0vpp3xdl	213	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	213	2	:	:	:
cord-007689-0vpp3xdl	213	3	C.	c.	NN
cord-007689-0vpp3xdl	214	1	However	however	RB
cord-007689-0vpp3xdl	214	2	,	,	,
cord-007689-0vpp3xdl	214	3	overexpression	overexpression	NN
cord-007689-0vpp3xdl	214	4	of	of	IN
cord-007689-0vpp3xdl	214	5	a	a	DT
cord-007689-0vpp3xdl	214	6	dominant	dominant	JJ
cord-007689-0vpp3xdl	214	7	negative	negative	JJ
cord-007689-0vpp3xdl	214	8	mutant	mutant	NN
cord-007689-0vpp3xdl	214	9	of	of	IN
cord-007689-0vpp3xdl	214	10	RIG	rig	NN
cord-007689-0vpp3xdl	214	11	-	-	:
cord-007689-0vpp3xdl	214	12	I	-PRON-	PRP
cord-007689-0vpp3xdl	214	13	impaired	impair	VBD
cord-007689-0vpp3xdl	214	14	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	214	15	activation	activation	NN
cord-007689-0vpp3xdl	214	16	by	by	IN
cord-007689-0vpp3xdl	214	17	Newcastle	Newcastle	NNP
cord-007689-0vpp3xdl	214	18	disease	disease	NN
cord-007689-0vpp3xdl	214	19	virus	virus	NN
cord-007689-0vpp3xdl	214	20	(	(	-LRB-
cord-007689-0vpp3xdl	214	21	NDV	NDV	NNP
cord-007689-0vpp3xdl	214	22	)	)	-RRB-
cord-007689-0vpp3xdl	214	23	,	,	,
cord-007689-0vpp3xdl	214	24	a	a	DT
cord-007689-0vpp3xdl	214	25	negative	negative	JJ
cord-007689-0vpp3xdl	214	26	-	-	HYPH
cord-007689-0vpp3xdl	214	27	strand	strand	NN
cord-007689-0vpp3xdl	214	28	RNA	RNA	NNP
cord-007689-0vpp3xdl	214	29	virus	virus	NN
cord-007689-0vpp3xdl	214	30	,	,	,
cord-007689-0vpp3xdl	214	31	while	while	IN
cord-007689-0vpp3xdl	214	32	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	214	33	activation	activation	NN
cord-007689-0vpp3xdl	214	34	by	by	IN
cord-007689-0vpp3xdl	214	35	poly	poly	NNP
cord-007689-0vpp3xdl	214	36	I	I	NNP
cord-007689-0vpp3xdl	214	37	:	:	:
cord-007689-0vpp3xdl	214	38	C	C	NNP
cord-007689-0vpp3xdl	214	39	was	be	VBD
cord-007689-0vpp3xdl	214	40	not	not	RB
cord-007689-0vpp3xdl	214	41	inhibited	inhibit	VBN
cord-007689-0vpp3xdl	214	42	.	.	.
cord-007689-0vpp3xdl	215	1	Subsequent	subsequent	JJ
cord-007689-0vpp3xdl	215	2	studies	study	NNS
cord-007689-0vpp3xdl	215	3	with	with	IN
cord-007689-0vpp3xdl	215	4	RIG-	RIG-	NNP
cord-007689-0vpp3xdl	216	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	216	2	-/mice	-/mice	VBP
cord-007689-0vpp3xdl	216	3	and	and	CC
cord-007689-0vpp3xdl	216	4	MEFs	mef	NNS
cord-007689-0vpp3xdl	216	5	showed	show	VBD
cord-007689-0vpp3xdl	216	6	no	no	DT
cord-007689-0vpp3xdl	216	7	defect	defect	NN
cord-007689-0vpp3xdl	216	8	in	in	IN
cord-007689-0vpp3xdl	216	9	the	the	DT
cord-007689-0vpp3xdl	216	10	response	response	NN
cord-007689-0vpp3xdl	216	11	to	to	IN
cord-007689-0vpp3xdl	216	12	poly	poly	NNP
cord-007689-0vpp3xdl	216	13	I	I	NNP
cord-007689-0vpp3xdl	216	14	:	:	:
cord-007689-0vpp3xdl	216	15	C.	C.	NNP
cord-007689-0vpp3xdl	216	16	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	216	17	and	and	CC
cord-007689-0vpp3xdl	216	18	colleagues	colleague	NNS
cord-007689-0vpp3xdl	216	19	(	(	-LRB-
cord-007689-0vpp3xdl	216	20	2006	2006	CD
cord-007689-0vpp3xdl	216	21	)	)	-RRB-
cord-007689-0vpp3xdl	216	22	demonstrated	demonstrate	VBD
cord-007689-0vpp3xdl	216	23	that	that	IN
cord-007689-0vpp3xdl	216	24	RIG	rig	NN
cord-007689-0vpp3xdl	216	25	-	-	:
cord-007689-0vpp3xdl	216	26	I	-PRON-	PRP
cord-007689-0vpp3xdl	216	27	detects	detect	VBZ
cord-007689-0vpp3xdl	216	28	in	in	IN
cord-007689-0vpp3xdl	216	29	vitro	vitro	FW
cord-007689-0vpp3xdl	216	30	transcribed	transcribe	VBN
cord-007689-0vpp3xdl	216	31	RNA	RNA	NNP
cord-007689-0vpp3xdl	216	32	.	.	.
cord-007689-0vpp3xdl	217	1	RNA	RNA	NNP
cord-007689-0vpp3xdl	217	2	with	with	IN
cord-007689-0vpp3xdl	217	3	a	a	DT
cord-007689-0vpp3xdl	217	4	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	217	5	at	at	IN
cord-007689-0vpp3xdl	217	6	the	the	DT
cord-007689-0vpp3xdl	217	7	5′	5′	CD
cord-007689-0vpp3xdl	217	8	end	end	NN
cord-007689-0vpp3xdl	217	9	(	(	-LRB-
cord-007689-0vpp3xdl	217	10	now	now	RB
cord-007689-0vpp3xdl	217	11	termed	term	VBN
cord-007689-0vpp3xdl	217	12	3pRNA	3prna	CD
cord-007689-0vpp3xdl	217	13	)	)	-RRB-
cord-007689-0vpp3xdl	217	14	,	,	,
cord-007689-0vpp3xdl	217	15	which	which	WDT
cord-007689-0vpp3xdl	217	16	is	be	VBZ
cord-007689-0vpp3xdl	217	17	generated	generate	VBN
cord-007689-0vpp3xdl	217	18	during	during	IN
cord-007689-0vpp3xdl	217	19	in	in	IN
cord-007689-0vpp3xdl	217	20	vitro	vitro	FW
cord-007689-0vpp3xdl	217	21	transcription	transcription	NN
cord-007689-0vpp3xdl	217	22	,	,	,
cord-007689-0vpp3xdl	217	23	was	be	VBD
cord-007689-0vpp3xdl	217	24	identified	identify	VBN
cord-007689-0vpp3xdl	217	25	to	to	TO
cord-007689-0vpp3xdl	217	26	be	be	VB
cord-007689-0vpp3xdl	217	27	the	the	DT
cord-007689-0vpp3xdl	217	28	ligand	ligand	NN
cord-007689-0vpp3xdl	217	29	for	for	IN
cord-007689-0vpp3xdl	217	30	RIG	rig	NN
cord-007689-0vpp3xdl	217	31	-	-	HYPH
cord-007689-0vpp3xdl	217	32	I.	i.	NN
cord-007689-0vpp3xdl	218	1	The	the	DT
cord-007689-0vpp3xdl	218	2	minimal	minimal	JJ
cord-007689-0vpp3xdl	218	3	length	length	NN
cord-007689-0vpp3xdl	218	4	of	of	IN
cord-007689-0vpp3xdl	218	5	3pRNA	3prna	CD
cord-007689-0vpp3xdl	218	6	was	be	VBD
cord-007689-0vpp3xdl	218	7	19	19	CD
cord-007689-0vpp3xdl	218	8	nucleotides	nucleotide	NNS
cord-007689-0vpp3xdl	218	9	.	.	.
cord-007689-0vpp3xdl	219	1	The	the	DT
cord-007689-0vpp3xdl	219	2	activity	activity	NN
cord-007689-0vpp3xdl	219	3	of	of	IN
cord-007689-0vpp3xdl	219	4	3pRNA	3prna	CD
cord-007689-0vpp3xdl	219	5	was	be	VBD
cord-007689-0vpp3xdl	219	6	independent	independent	JJ
cord-007689-0vpp3xdl	219	7	of	of	IN
cord-007689-0vpp3xdl	219	8	double	double	JJ
cord-007689-0vpp3xdl	219	9	-	-	HYPH
cord-007689-0vpp3xdl	219	10	strand	strand	NN
cord-007689-0vpp3xdl	219	11	formation	formation	NN
cord-007689-0vpp3xdl	219	12	.	.	.
cord-007689-0vpp3xdl	220	1	Both	both	DT
cord-007689-0vpp3xdl	220	2	exogenous	exogenous	JJ
cord-007689-0vpp3xdl	220	3	3pRNA	3pRNA	NNS
cord-007689-0vpp3xdl	220	4	transfected	transfecte	VBN
cord-007689-0vpp3xdl	220	5	into	into	IN
cord-007689-0vpp3xdl	220	6	the	the	DT
cord-007689-0vpp3xdl	220	7	cell	cell	NN
cord-007689-0vpp3xdl	220	8	and	and	CC
cord-007689-0vpp3xdl	220	9	endogenously	endogenously	RB
cord-007689-0vpp3xdl	220	10	formed	form	VBN
cord-007689-0vpp3xdl	220	11	3pRNA	3prna	CD
cord-007689-0vpp3xdl	220	12	(	(	-LRB-
cord-007689-0vpp3xdl	220	13	expression	expression	NN
cord-007689-0vpp3xdl	220	14	of	of	IN
cord-007689-0vpp3xdl	220	15	T7	T7	NNP
cord-007689-0vpp3xdl	220	16	RNA	RNA	NNP
cord-007689-0vpp3xdl	220	17	polymerase	polymerase	NN
cord-007689-0vpp3xdl	220	18	)	)	-RRB-
cord-007689-0vpp3xdl	220	19	activated	activate	VBN
cord-007689-0vpp3xdl	220	20	RIG	rig	NN
cord-007689-0vpp3xdl	220	21	-	-	HYPH
cord-007689-0vpp3xdl	220	22	I.	I.	NNP
cord-007689-0vpp3xdl	220	23	Genomic	Genomic	NNP
cord-007689-0vpp3xdl	220	24	RNA	RNA	NNP
cord-007689-0vpp3xdl	220	25	prepared	prepare	VBD
cord-007689-0vpp3xdl	220	26	from	from	IN
cord-007689-0vpp3xdl	220	27	a	a	DT
cord-007689-0vpp3xdl	220	28	negative	negative	JJ
cord-007689-0vpp3xdl	220	29	-	-	HYPH
cord-007689-0vpp3xdl	220	30	strand	strand	NN
cord-007689-0vpp3xdl	220	31	RNA	RNA	NNP
cord-007689-0vpp3xdl	220	32	virus	virus	NN
cord-007689-0vpp3xdl	220	33	and	and	CC
cord-007689-0vpp3xdl	220	34	RNA	RNA	NNP
cord-007689-0vpp3xdl	220	35	prepared	prepare	VBD
cord-007689-0vpp3xdl	220	36	from	from	IN
cord-007689-0vpp3xdl	220	37	virus	virus	NN
cord-007689-0vpp3xdl	220	38	-	-	HYPH
cord-007689-0vpp3xdl	220	39	infected	infect	VBN
cord-007689-0vpp3xdl	220	40	cells	cell	NNS
cord-007689-0vpp3xdl	220	41	,	,	,
cord-007689-0vpp3xdl	220	42	but	but	CC
cord-007689-0vpp3xdl	220	43	not	not	RB
cord-007689-0vpp3xdl	220	44	RNA	RNA	NNP
cord-007689-0vpp3xdl	220	45	from	from	IN
cord-007689-0vpp3xdl	220	46	noninfected	noninfected	JJ
cord-007689-0vpp3xdl	220	47	cells	cell	NNS
cord-007689-0vpp3xdl	220	48	,	,	,
cord-007689-0vpp3xdl	220	49	triggered	trigger	VBD
cord-007689-0vpp3xdl	220	50	a	a	DT
cord-007689-0vpp3xdl	220	51	potent	potent	JJ
cord-007689-0vpp3xdl	220	52	IFN	IFN	NNP
cord-007689-0vpp3xdl	220	53	-	-	HYPH
cord-007689-0vpp3xdl	220	54	α	α	NNP
cord-007689-0vpp3xdl	220	55	response	response	NN
cord-007689-0vpp3xdl	220	56	in	in	IN
cord-007689-0vpp3xdl	220	57	a	a	DT
cord-007689-0vpp3xdl	220	58	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	220	59	-	-	HYPH
cord-007689-0vpp3xdl	220	60	dependent	dependent	JJ
cord-007689-0vpp3xdl	220	61	manner	manner	NN
cord-007689-0vpp3xdl	220	62	.	.	.
cord-007689-0vpp3xdl	221	1	Binding	binding	NN
cord-007689-0vpp3xdl	221	2	studies	study	NNS
cord-007689-0vpp3xdl	221	3	of	of	IN
cord-007689-0vpp3xdl	221	4	RIG	rig	NN
cord-007689-0vpp3xdl	221	5	-	-	:
cord-007689-0vpp3xdl	221	6	I	I	NNP
cord-007689-0vpp3xdl	221	7	and	and	CC
cord-007689-0vpp3xdl	221	8	3pRNA	3pRNA	NNS
cord-007689-0vpp3xdl	221	9	revealed	reveal	VBD
cord-007689-0vpp3xdl	221	10	a	a	DT
cord-007689-0vpp3xdl	221	11	direct	direct	JJ
cord-007689-0vpp3xdl	221	12	molecular	molecular	JJ
cord-007689-0vpp3xdl	221	13	interaction	interaction	NN
cord-007689-0vpp3xdl	221	14	.	.	.
cord-007689-0vpp3xdl	222	1	The	the	DT
cord-007689-0vpp3xdl	222	2	5′	5′	CD
cord-007689-0vpp3xdl	222	3	capping	cap	VBG
cord-007689-0vpp3xdl	222	4	or	or	CC
cord-007689-0vpp3xdl	222	5	incorporation	incorporation	NN
cord-007689-0vpp3xdl	222	6	of	of	IN
cord-007689-0vpp3xdl	222	7	modified	modify	VBN
cord-007689-0vpp3xdl	222	8	nucleotides	nucleotide	NNS
cord-007689-0vpp3xdl	222	9	such	such	JJ
cord-007689-0vpp3xdl	222	10	as	as	IN
cord-007689-0vpp3xdl	222	11	pseudouridine	pseudouridine	NN
cord-007689-0vpp3xdl	222	12	,	,	,
cord-007689-0vpp3xdl	222	13	2-thiouridine	2-thiouridine	CD
cord-007689-0vpp3xdl	222	14	,	,	,
cord-007689-0vpp3xdl	222	15	and	and	CC
cord-007689-0vpp3xdl	222	16	2′-O	2′-o	CD
cord-007689-0vpp3xdl	222	17	-	-	HYPH
cord-007689-0vpp3xdl	222	18	methylated	methylate	VBN
cord-007689-0vpp3xdl	222	19	uridine	uridine	NN
cord-007689-0vpp3xdl	222	20	in	in	IN
cord-007689-0vpp3xdl	222	21	place	place	NN
cord-007689-0vpp3xdl	222	22	of	of	IN
cord-007689-0vpp3xdl	222	23	uridine	uridine	NN
cord-007689-0vpp3xdl	222	24	in	in	IN
cord-007689-0vpp3xdl	222	25	short	short	JJ
cord-007689-0vpp3xdl	222	26	3pRNA	3prna	CD
cord-007689-0vpp3xdl	222	27	strongly	strongly	RB
cord-007689-0vpp3xdl	222	28	diminished	diminish	VBD
cord-007689-0vpp3xdl	222	29	IFN	IFN	NNP
cord-007689-0vpp3xdl	222	30	-	-	HYPH
cord-007689-0vpp3xdl	222	31	α	α	NN
cord-007689-0vpp3xdl	222	32	induction	induction	NN
cord-007689-0vpp3xdl	222	33	.	.	.
cord-007689-0vpp3xdl	223	1	In	in	IN
cord-007689-0vpp3xdl	223	2	a	a	DT
cord-007689-0vpp3xdl	223	3	parallel	parallel	JJ
cord-007689-0vpp3xdl	223	4	study	study	NN
cord-007689-0vpp3xdl	223	5	,	,	,
cord-007689-0vpp3xdl	223	6	Pichlmair	Pichlmair	NNP
cord-007689-0vpp3xdl	223	7	et	et	NNP
cord-007689-0vpp3xdl	223	8	al	al	NNP
cord-007689-0vpp3xdl	223	9	.	.	.
cord-007689-0vpp3xdl	224	1	(	(	-LRB-
cord-007689-0vpp3xdl	224	2	2006	2006	CD
cord-007689-0vpp3xdl	224	3	)	)	-RRB-
cord-007689-0vpp3xdl	224	4	attributed	attribute	VBD
cord-007689-0vpp3xdl	224	5	the	the	DT
cord-007689-0vpp3xdl	224	6	inhibitory	inhibitory	JJ
cord-007689-0vpp3xdl	224	7	effect	effect	NN
cord-007689-0vpp3xdl	224	8	of	of	IN
cord-007689-0vpp3xdl	224	9	the	the	DT
cord-007689-0vpp3xdl	224	10	influenza	influenza	NN
cord-007689-0vpp3xdl	224	11	virus	virus	NN
cord-007689-0vpp3xdl	224	12	protein	protein	NN
cord-007689-0vpp3xdl	224	13	NS1	NS1	VBZ
cord-007689-0vpp3xdl	224	14	to	to	IN
cord-007689-0vpp3xdl	224	15	its	-PRON-	PRP$
cord-007689-0vpp3xdl	224	16	binding	binding	NN
cord-007689-0vpp3xdl	224	17	and	and	CC
cord-007689-0vpp3xdl	224	18	inhibition	inhibition	NN
cord-007689-0vpp3xdl	224	19	of	of	IN
cord-007689-0vpp3xdl	224	20	the	the	DT
cord-007689-0vpp3xdl	224	21	RIG	rig	NN
cord-007689-0vpp3xdl	224	22	-	-	HYPH
cord-007689-0vpp3xdl	224	23	I	-PRON-	PRP
cord-007689-0vpp3xdl	224	24	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	224	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	224	26	complex	complex	NN
cord-007689-0vpp3xdl	224	27	.	.	.
cord-007689-0vpp3xdl	225	1	These	these	DT
cord-007689-0vpp3xdl	225	2	results	result	NNS
cord-007689-0vpp3xdl	225	3	provide	provide	VBP
cord-007689-0vpp3xdl	225	4	evidence	evidence	NN
cord-007689-0vpp3xdl	225	5	that	that	IN
cord-007689-0vpp3xdl	225	6	uncapped	uncapped	JJ
cord-007689-0vpp3xdl	225	7	unmodified	unmodified	JJ
cord-007689-0vpp3xdl	225	8	3pRNA	3pRNA	NNS
cord-007689-0vpp3xdl	225	9	is	be	VBZ
cord-007689-0vpp3xdl	225	10	detected	detect	VBN
cord-007689-0vpp3xdl	225	11	by	by	IN
cord-007689-0vpp3xdl	225	12	RIG	rig	NN
cord-007689-0vpp3xdl	225	13	-	-	:
cord-007689-0vpp3xdl	225	14	I	-PRON-	PRP
cord-007689-0vpp3xdl	225	15	in	in	IN
cord-007689-0vpp3xdl	225	16	the	the	DT
cord-007689-0vpp3xdl	225	17	cytosol	cytosol	NN
cord-007689-0vpp3xdl	225	18	of	of	IN
cord-007689-0vpp3xdl	225	19	eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	225	20	cells	cell	NNS
cord-007689-0vpp3xdl	225	21	.	.	.
cord-007689-0vpp3xdl	226	1	Of	of	IN
cord-007689-0vpp3xdl	226	2	note	note	VB
cord-007689-0vpp3xdl	226	3	,	,	,
cord-007689-0vpp3xdl	226	4	all	all	DT
cord-007689-0vpp3xdl	226	5	primer	primer	NN
cord-007689-0vpp3xdl	226	6	-	-	HYPH
cord-007689-0vpp3xdl	226	7	independent	independent	JJ
cord-007689-0vpp3xdl	226	8	RNA	RNA	NNP
cord-007689-0vpp3xdl	226	9	transcripts	transcript	NNS
cord-007689-0vpp3xdl	226	10	in	in	IN
cord-007689-0vpp3xdl	226	11	a	a	DT
cord-007689-0vpp3xdl	226	12	normal	normal	JJ
cord-007689-0vpp3xdl	226	13	uninfected	uninfected	JJ
cord-007689-0vpp3xdl	226	14	cell	cell	NN
cord-007689-0vpp3xdl	226	15	initially	initially	RB
cord-007689-0vpp3xdl	226	16	contain	contain	VBP
cord-007689-0vpp3xdl	226	17	a	a	DT
cord-007689-0vpp3xdl	226	18	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	226	19	end	end	NN
cord-007689-0vpp3xdl	226	20	.	.	.
cord-007689-0vpp3xdl	227	1	However	however	RB
cord-007689-0vpp3xdl	227	2	,	,	,
cord-007689-0vpp3xdl	227	3	most	most	JJS
cord-007689-0vpp3xdl	227	4	if	if	IN
cord-007689-0vpp3xdl	227	5	not	not	RB
cord-007689-0vpp3xdl	227	6	all	all	DT
cord-007689-0vpp3xdl	227	7	self	self	NN
cord-007689-0vpp3xdl	227	8	-	-	HYPH
cord-007689-0vpp3xdl	227	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	227	10	species	specie	NNS
cord-007689-0vpp3xdl	227	11	entering	enter	VBG
cord-007689-0vpp3xdl	227	12	the	the	DT
cord-007689-0vpp3xdl	227	13	cytosol	cytosol	NN
cord-007689-0vpp3xdl	227	14	lack	lack	VBP
cord-007689-0vpp3xdl	227	15	a	a	DT
cord-007689-0vpp3xdl	227	16	free	free	JJ
cord-007689-0vpp3xdl	227	17	5′triphosphate	5′triphosphate	CD
cord-007689-0vpp3xdl	227	18	end	end	NN
cord-007689-0vpp3xdl	227	19	.	.	.
cord-007689-0vpp3xdl	228	1	Before	before	IN
cord-007689-0vpp3xdl	228	2	self	self	NN
cord-007689-0vpp3xdl	228	3	-	-	HYPH
cord-007689-0vpp3xdl	228	4	RNA	RNA	NNP
cord-007689-0vpp3xdl	228	5	leaves	leave	VBZ
cord-007689-0vpp3xdl	228	6	the	the	DT
cord-007689-0vpp3xdl	228	7	nucleus	nucleus	NN
cord-007689-0vpp3xdl	228	8	,	,	,
cord-007689-0vpp3xdl	228	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	228	10	is	be	VBZ
cord-007689-0vpp3xdl	228	11	further	far	RBR
cord-007689-0vpp3xdl	228	12	processed	process	VBN
cord-007689-0vpp3xdl	228	13	,	,	,
cord-007689-0vpp3xdl	228	14	which	which	WDT
cord-007689-0vpp3xdl	228	15	applies	apply	VBZ
cord-007689-0vpp3xdl	228	16	to	to	IN
cord-007689-0vpp3xdl	228	17	RNA	RNA	NNP
cord-007689-0vpp3xdl	228	18	transcripts	transcript	NNS
cord-007689-0vpp3xdl	228	19	of	of	IN
cord-007689-0vpp3xdl	228	20	all	all	DT
cord-007689-0vpp3xdl	228	21	three	three	CD
cord-007689-0vpp3xdl	228	22	DNA	dna	NN
cord-007689-0vpp3xdl	228	23	-	-	HYPH
cord-007689-0vpp3xdl	228	24	dependent	dependent	JJ
cord-007689-0vpp3xdl	228	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	228	26	polymerases	polymerase	NNS
cord-007689-0vpp3xdl	228	27	(	(	-LRB-
cord-007689-0vpp3xdl	228	28	pol	pol	NNP
cord-007689-0vpp3xdl	228	29	)	)	-RRB-
cord-007689-0vpp3xdl	228	30	in	in	IN
cord-007689-0vpp3xdl	228	31	eukaryotes	eukaryote	NNS
cord-007689-0vpp3xdl	228	32	.	.	.
cord-007689-0vpp3xdl	229	1	Pol	Pol	NNP
cord-007689-0vpp3xdl	229	2	I	-PRON-	PRP
cord-007689-0vpp3xdl	229	3	transcribes	transcribe	VBZ
cord-007689-0vpp3xdl	229	4	a	a	DT
cord-007689-0vpp3xdl	229	5	large	large	JJ
cord-007689-0vpp3xdl	229	6	polycistronic	polycistronic	JJ
cord-007689-0vpp3xdl	229	7	precursor	precursor	NN
cord-007689-0vpp3xdl	229	8	of	of	IN
cord-007689-0vpp3xdl	229	9	ribosomal	ribosomal	NNP
cord-007689-0vpp3xdl	229	10	RNA	RNA	NNP
cord-007689-0vpp3xdl	229	11	(	(	-LRB-
cord-007689-0vpp3xdl	229	12	rRNA	rRNA	NNP
cord-007689-0vpp3xdl	229	13	)	)	-RRB-
cord-007689-0vpp3xdl	229	14	that	that	WDT
cord-007689-0vpp3xdl	229	15	contains	contain	VBZ
cord-007689-0vpp3xdl	229	16	the	the	DT
cord-007689-0vpp3xdl	229	17	sequences	sequence	NNS
cord-007689-0vpp3xdl	229	18	for	for	IN
cord-007689-0vpp3xdl	229	19	the	the	DT
cord-007689-0vpp3xdl	229	20	mature	mature	JJ
cord-007689-0vpp3xdl	229	21	rRNAs	rrna	NNS
cord-007689-0vpp3xdl	230	1	(	(	-LRB-
cord-007689-0vpp3xdl	230	2	18	18	CD
cord-007689-0vpp3xdl	230	3	,	,	,
cord-007689-0vpp3xdl	230	4	5.8S	5.8s	CD
cord-007689-0vpp3xdl	230	5	,	,	,
cord-007689-0vpp3xdl	230	6	25	25	CD
cord-007689-0vpp3xdl	230	7	-	-	HYPH
cord-007689-0vpp3xdl	230	8	28S	28S	NNP
cord-007689-0vpp3xdl	230	9	rRNA	rRNA	NNP
cord-007689-0vpp3xdl	230	10	)	)	-RRB-
cord-007689-0vpp3xdl	230	11	,	,	,
cord-007689-0vpp3xdl	230	12	two	two	CD
cord-007689-0vpp3xdl	230	13	external	external	JJ
cord-007689-0vpp3xdl	230	14	transcribed	transcribe	VBN
cord-007689-0vpp3xdl	230	15	spacers	spacer	NNS
cord-007689-0vpp3xdl	230	16	,	,	,
cord-007689-0vpp3xdl	230	17	and	and	CC
cord-007689-0vpp3xdl	230	18	two	two	CD
cord-007689-0vpp3xdl	230	19	internal	internal	JJ
cord-007689-0vpp3xdl	230	20	transcribed	transcribe	VBN
cord-007689-0vpp3xdl	230	21	spacers	spacer	NNS
cord-007689-0vpp3xdl	230	22	.	.	.
cord-007689-0vpp3xdl	231	1	This	this	DT
cord-007689-0vpp3xdl	231	2	primary	primary	JJ
cord-007689-0vpp3xdl	231	3	transcript	transcript	NN
cord-007689-0vpp3xdl	231	4	is	be	VBZ
cord-007689-0vpp3xdl	231	5	subjected	subject	VBN
cord-007689-0vpp3xdl	231	6	to	to	IN
cord-007689-0vpp3xdl	231	7	endo	endo	NN
cord-007689-0vpp3xdl	231	8	-	-	,
cord-007689-0vpp3xdl	231	9	and	and	CC
cord-007689-0vpp3xdl	231	10	exonucleolytic	exonucleolytic	JJ
cord-007689-0vpp3xdl	231	11	processing	processing	NN
cord-007689-0vpp3xdl	231	12	steps	step	NNS
cord-007689-0vpp3xdl	231	13	to	to	TO
cord-007689-0vpp3xdl	231	14	produce	produce	VB
cord-007689-0vpp3xdl	231	15	the	the	DT
cord-007689-0vpp3xdl	231	16	mature	mature	JJ
cord-007689-0vpp3xdl	231	17	rRNAs	rrna	NNS
cord-007689-0vpp3xdl	231	18	.	.	.
cord-007689-0vpp3xdl	232	1	The	the	DT
cord-007689-0vpp3xdl	232	2	net	net	JJ
cord-007689-0vpp3xdl	232	3	result	result	NN
cord-007689-0vpp3xdl	232	4	of	of	IN
cord-007689-0vpp3xdl	232	5	this	this	DT
cord-007689-0vpp3xdl	232	6	maturation	maturation	NN
cord-007689-0vpp3xdl	232	7	process	process	NN
cord-007689-0vpp3xdl	232	8	is	be	VBZ
cord-007689-0vpp3xdl	232	9	a	a	DT
cord-007689-0vpp3xdl	232	10	monophosphate	monophosphate	NN
cord-007689-0vpp3xdl	232	11	group	group	NN
cord-007689-0vpp3xdl	232	12	at	at	IN
cord-007689-0vpp3xdl	232	13	the	the	DT
cord-007689-0vpp3xdl	232	14	5′	5′	CD
cord-007689-0vpp3xdl	232	15	end	end	NN
cord-007689-0vpp3xdl	232	16	of	of	IN
cord-007689-0vpp3xdl	232	17	all	all	DT
cord-007689-0vpp3xdl	232	18	pol	pol	NN
cord-007689-0vpp3xdl	232	19	I	-PRON-	PRP
cord-007689-0vpp3xdl	232	20	transcribed	transcribe	VBD
cord-007689-0vpp3xdl	232	21	rRNAs	rrna	NNS
cord-007689-0vpp3xdl	233	1	(	(	-LRB-
cord-007689-0vpp3xdl	233	2	Fromont	Fromont	NNP
cord-007689-0vpp3xdl	233	3	-	-	HYPH
cord-007689-0vpp3xdl	233	4	Racine	Racine	NNP
cord-007689-0vpp3xdl	233	5	et	et	FW
cord-007689-0vpp3xdl	233	6	al	al	NNP
cord-007689-0vpp3xdl	233	7	.	.	NNP
cord-007689-0vpp3xdl	233	8	2003	2003	CD
cord-007689-0vpp3xdl	233	9	)	)	-RRB-
cord-007689-0vpp3xdl	233	10	.	.	.
cord-007689-0vpp3xdl	234	1	Messenger	Messenger	NNP
cord-007689-0vpp3xdl	234	2	RNAs	rna	NNS
cord-007689-0vpp3xdl	234	3	(	(	-LRB-
cord-007689-0vpp3xdl	234	4	mRNAs	mrnas	CD
cord-007689-0vpp3xdl	234	5	)	)	-RRB-
cord-007689-0vpp3xdl	234	6	and	and	CC
cord-007689-0vpp3xdl	234	7	small	small	JJ
cord-007689-0vpp3xdl	234	8	nuclear	nuclear	JJ
cord-007689-0vpp3xdl	234	9	RNAs	rna	NNS
cord-007689-0vpp3xdl	234	10	(	(	-LRB-
cord-007689-0vpp3xdl	234	11	snRNAs	snRNAs	NNP
cord-007689-0vpp3xdl	234	12	)	)	-RRB-
cord-007689-0vpp3xdl	234	13	,	,	,
cord-007689-0vpp3xdl	234	14	which	which	WDT
cord-007689-0vpp3xdl	234	15	are	be	VBP
cord-007689-0vpp3xdl	234	16	transcribed	transcribe	VBN
cord-007689-0vpp3xdl	234	17	by	by	IN
cord-007689-0vpp3xdl	234	18	pol	pol	NNP
cord-007689-0vpp3xdl	234	19	II	II	NNP
cord-007689-0vpp3xdl	234	20	,	,	,
cord-007689-0vpp3xdl	234	21	receive	receive	VBP
cord-007689-0vpp3xdl	234	22	a	a	DT
cord-007689-0vpp3xdl	234	23	7-methyl	7-methyl	CD
cord-007689-0vpp3xdl	234	24	guanosine	guanosine	NN
cord-007689-0vpp3xdl	234	25	group	group	NN
cord-007689-0vpp3xdl	234	26	that	that	WDT
cord-007689-0vpp3xdl	234	27	is	be	VBZ
cord-007689-0vpp3xdl	234	28	attached	attach	VBN
cord-007689-0vpp3xdl	234	29	to	to	IN
cord-007689-0vpp3xdl	234	30	the	the	DT
cord-007689-0vpp3xdl	234	31	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	234	32	of	of	IN
cord-007689-0vpp3xdl	234	33	the	the	DT
cord-007689-0vpp3xdl	234	34	nascent	nascent	JJ
cord-007689-0vpp3xdl	234	35	RNA	RNA	NNP
cord-007689-0vpp3xdl	234	36	by	by	IN
cord-007689-0vpp3xdl	234	37	a	a	DT
cord-007689-0vpp3xdl	234	38	process	process	NN
cord-007689-0vpp3xdl	234	39	called	call	VBN
cord-007689-0vpp3xdl	234	40	capping	cap	VBG
cord-007689-0vpp3xdl	234	41	(	(	-LRB-
cord-007689-0vpp3xdl	234	42	Shatkin	Shatkin	NNP
cord-007689-0vpp3xdl	234	43	and	and	CC
cord-007689-0vpp3xdl	234	44	Manley	Manley	NNP
cord-007689-0vpp3xdl	234	45	2000	2000	CD
cord-007689-0vpp3xdl	234	46	)	)	-RRB-
cord-007689-0vpp3xdl	234	47	.	.	.
cord-007689-0vpp3xdl	235	1	Thus	thus	RB
cord-007689-0vpp3xdl	235	2	,	,	,
cord-007689-0vpp3xdl	235	3	upon	upon	IN
cord-007689-0vpp3xdl	235	4	export	export	NN
cord-007689-0vpp3xdl	235	5	into	into	IN
cord-007689-0vpp3xdl	235	6	the	the	DT
cord-007689-0vpp3xdl	235	7	cytoplasm	cytoplasm	NN
cord-007689-0vpp3xdl	235	8	,	,	,
cord-007689-0vpp3xdl	235	9	no	no	DT
cord-007689-0vpp3xdl	235	10	free	free	JJ
cord-007689-0vpp3xdl	235	11	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	235	12	groups	group	NNS
cord-007689-0vpp3xdl	235	13	are	be	VBP
cord-007689-0vpp3xdl	235	14	found	find	VBN
cord-007689-0vpp3xdl	235	15	in	in	IN
cord-007689-0vpp3xdl	235	16	pol	pol	NNP
cord-007689-0vpp3xdl	235	17	II	II	NNP
cord-007689-0vpp3xdl	235	18	transcripts	transcript	NNS
cord-007689-0vpp3xdl	235	19	.	.	.
cord-007689-0vpp3xdl	236	1	All	all	DT
cord-007689-0vpp3xdl	236	2	mature	mature	VBP
cord-007689-0vpp3xdl	236	3	tRNAs	trna	NNS
cord-007689-0vpp3xdl	237	1	(	(	-LRB-
cord-007689-0vpp3xdl	237	2	pol	pol	NNP
cord-007689-0vpp3xdl	237	3	III	III	NNP
cord-007689-0vpp3xdl	237	4	)	)	-RRB-
cord-007689-0vpp3xdl	237	5	have	have	VBP
cord-007689-0vpp3xdl	237	6	a	a	DT
cord-007689-0vpp3xdl	237	7	5′-monophosphate	5′-monophosphate	CD
cord-007689-0vpp3xdl	237	8	(	(	-LRB-
cord-007689-0vpp3xdl	237	9	Xiao	Xiao	NNP
cord-007689-0vpp3xdl	237	10	et	et	NNP
cord-007689-0vpp3xdl	237	11	al	al	NNP
cord-007689-0vpp3xdl	237	12	.	.	.
cord-007689-0vpp3xdl	237	13	2002	2002	CD
cord-007689-0vpp3xdl	237	14	)	)	-RRB-
cord-007689-0vpp3xdl	237	15	,	,	,
cord-007689-0vpp3xdl	237	16	as	as	IN
cord-007689-0vpp3xdl	237	17	it	-PRON-	PRP
cord-007689-0vpp3xdl	237	18	is	be	VBZ
cord-007689-0vpp3xdl	237	19	likely	likely	JJ
cord-007689-0vpp3xdl	237	20	to	to	TO
cord-007689-0vpp3xdl	237	21	apply	apply	VB
cord-007689-0vpp3xdl	237	22	to	to	IN
cord-007689-0vpp3xdl	237	23	5S	5S	NNP
cord-007689-0vpp3xdl	237	24	rRNA	rRNA	NNP
cord-007689-0vpp3xdl	237	25	.	.	.
cord-007689-0vpp3xdl	238	1	U6	U6	NNP
cord-007689-0vpp3xdl	238	2	RNA	RNA	NNP
cord-007689-0vpp3xdl	238	3	receives	receive	VBZ
cord-007689-0vpp3xdl	238	4	a	a	DT
cord-007689-0vpp3xdl	238	5	γ	γ	NN
cord-007689-0vpp3xdl	238	6	-	-	HYPH
cord-007689-0vpp3xdl	238	7	monomethylphosphate	monomethylphosphate	NNP
cord-007689-0vpp3xdl	238	8	cap	cap	NN
cord-007689-0vpp3xdl	238	9	structure	structure	NN
cord-007689-0vpp3xdl	238	10	following	follow	VBG
cord-007689-0vpp3xdl	238	11	transcription	transcription	NN
cord-007689-0vpp3xdl	238	12	.	.	.
cord-007689-0vpp3xdl	239	1	However	however	RB
cord-007689-0vpp3xdl	239	2	,	,	,
cord-007689-0vpp3xdl	239	3	7SL	7SL	NNP
cord-007689-0vpp3xdl	239	4	RNA	RNA	NNP
cord-007689-0vpp3xdl	239	5	(	(	-LRB-
cord-007689-0vpp3xdl	239	6	pol	pol	NNP
cord-007689-0vpp3xdl	239	7	III	III	NNP
cord-007689-0vpp3xdl	239	8	)	)	-RRB-
cord-007689-0vpp3xdl	239	9	has	have	VBZ
cord-007689-0vpp3xdl	239	10	a	a	DT
cord-007689-0vpp3xdl	239	11	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	239	12	at	at	IN
cord-007689-0vpp3xdl	239	13	the	the	DT
cord-007689-0vpp3xdl	239	14	5′	5′	CD
cord-007689-0vpp3xdl	239	15	end	end	NN
cord-007689-0vpp3xdl	239	16	,	,	,
cord-007689-0vpp3xdl	239	17	and	and	CC
cord-007689-0vpp3xdl	239	18	is	be	VBZ
cord-007689-0vpp3xdl	239	19	present	present	JJ
cord-007689-0vpp3xdl	239	20	at	at	IN
cord-007689-0vpp3xdl	239	21	high	high	JJ
cord-007689-0vpp3xdl	239	22	copy	copy	NN
cord-007689-0vpp3xdl	239	23	numbers	number	NNS
cord-007689-0vpp3xdl	239	24	in	in	IN
cord-007689-0vpp3xdl	239	25	the	the	DT
cord-007689-0vpp3xdl	239	26	cytosol	cytosol	NN
cord-007689-0vpp3xdl	239	27	.	.	.
cord-007689-0vpp3xdl	240	1	Therefore	therefore	RB
cord-007689-0vpp3xdl	240	2	,	,	,
cord-007689-0vpp3xdl	240	3	the	the	DT
cord-007689-0vpp3xdl	240	4	presence	presence	NN
cord-007689-0vpp3xdl	240	5	or	or	CC
cord-007689-0vpp3xdl	240	6	absence	absence	NN
cord-007689-0vpp3xdl	240	7	of	of	IN
cord-007689-0vpp3xdl	240	8	a	a	DT
cord-007689-0vpp3xdl	240	9	5′	5′	CD
cord-007689-0vpp3xdl	240	10	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	240	11	might	may	MD
cord-007689-0vpp3xdl	240	12	not	not	RB
cord-007689-0vpp3xdl	240	13	be	be	VB
cord-007689-0vpp3xdl	240	14	the	the	DT
cord-007689-0vpp3xdl	240	15	only	only	JJ
cord-007689-0vpp3xdl	240	16	structural	structural	JJ
cord-007689-0vpp3xdl	240	17	feature	feature	NN
cord-007689-0vpp3xdl	240	18	of	of	IN
cord-007689-0vpp3xdl	240	19	RNA	RNA	NNP
cord-007689-0vpp3xdl	240	20	responsible	responsible	JJ
cord-007689-0vpp3xdl	240	21	for	for	IN
cord-007689-0vpp3xdl	240	22	the	the	DT
cord-007689-0vpp3xdl	240	23	distinction	distinction	NN
cord-007689-0vpp3xdl	240	24	of	of	IN
cord-007689-0vpp3xdl	240	25	self	self	NN
cord-007689-0vpp3xdl	240	26	and	and	CC
cord-007689-0vpp3xdl	240	27	viral	viral	JJ
cord-007689-0vpp3xdl	240	28	RNA	RNA	NNP
cord-007689-0vpp3xdl	240	29	.	.	.
cord-007689-0vpp3xdl	241	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	241	2	is	be	VBZ
cord-007689-0vpp3xdl	241	3	well	well	RB
cord-007689-0vpp3xdl	241	4	known	know	VBN
cord-007689-0vpp3xdl	241	5	that	that	IN
cord-007689-0vpp3xdl	241	6	eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	241	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	241	8	undergoes	undergo	VBZ
cord-007689-0vpp3xdl	241	9	significant	significant	JJ
cord-007689-0vpp3xdl	241	10	modifications	modification	NNS
cord-007689-0vpp3xdl	241	11	to	to	IN
cord-007689-0vpp3xdl	241	12	its	-PRON-	PRP$
cord-007689-0vpp3xdl	241	13	nucleosides	nucleoside	NNS
cord-007689-0vpp3xdl	241	14	and	and	CC
cord-007689-0vpp3xdl	241	15	its	-PRON-	PRP$
cord-007689-0vpp3xdl	241	16	ribose	ribose	NN
cord-007689-0vpp3xdl	241	17	backbone	backbone	NN
cord-007689-0vpp3xdl	241	18	.	.	.
cord-007689-0vpp3xdl	242	1	Among	among	IN
cord-007689-0vpp3xdl	242	2	all	all	DT
cord-007689-0vpp3xdl	242	3	nucleoside	nucleoside	NN
cord-007689-0vpp3xdl	242	4	modifications	modification	NNS
cord-007689-0vpp3xdl	242	5	,	,	,
cord-007689-0vpp3xdl	242	6	pseudouridinylation	pseudouridinylation	NN
cord-007689-0vpp3xdl	242	7	is	be	VBZ
cord-007689-0vpp3xdl	242	8	one	one	CD
cord-007689-0vpp3xdl	242	9	of	of	IN
cord-007689-0vpp3xdl	242	10	the	the	DT
cord-007689-0vpp3xdl	242	11	most	most	RBS
cord-007689-0vpp3xdl	242	12	common	common	JJ
cord-007689-0vpp3xdl	242	13	post	post	JJ
cord-007689-0vpp3xdl	242	14	-	-	JJ
cord-007689-0vpp3xdl	242	15	transcriptional	transcriptional	JJ
cord-007689-0vpp3xdl	242	16	modifications	modification	NNS
cord-007689-0vpp3xdl	242	17	of	of	IN
cord-007689-0vpp3xdl	242	18	RNA	RNA	NNP
cord-007689-0vpp3xdl	242	19	that	that	WDT
cord-007689-0vpp3xdl	242	20	appears	appear	VBZ
cord-007689-0vpp3xdl	242	21	to	to	TO
cord-007689-0vpp3xdl	242	22	be	be	VB
cord-007689-0vpp3xdl	242	23	universal	universal	JJ
cord-007689-0vpp3xdl	242	24	among	among	IN
cord-007689-0vpp3xdl	242	25	rRNAs	rrna	NNS
cord-007689-0vpp3xdl	242	26	and	and	CC
cord-007689-0vpp3xdl	242	27	small	small	JJ
cord-007689-0vpp3xdl	242	28	stable	stable	JJ
cord-007689-0vpp3xdl	242	29	RNAs	rna	NNS
cord-007689-0vpp3xdl	242	30	such	such	JJ
cord-007689-0vpp3xdl	242	31	as	as	IN
cord-007689-0vpp3xdl	242	32	splicing	splice	VBG
cord-007689-0vpp3xdl	242	33	small	small	JJ
cord-007689-0vpp3xdl	242	34	nuclear	nuclear	JJ
cord-007689-0vpp3xdl	242	35	RNAs	rna	NNS
cord-007689-0vpp3xdl	242	36	(	(	-LRB-
cord-007689-0vpp3xdl	242	37	snRNAs	snRNAs	NNP
cord-007689-0vpp3xdl	242	38	)	)	-RRB-
cord-007689-0vpp3xdl	242	39	,	,	,
cord-007689-0vpp3xdl	242	40	tRNAs	trna	NNS
cord-007689-0vpp3xdl	242	41	,	,	,
cord-007689-0vpp3xdl	242	42	and	and	CC
cord-007689-0vpp3xdl	242	43	small	small	JJ
cord-007689-0vpp3xdl	242	44	nucleolar	nucleolar	JJ
cord-007689-0vpp3xdl	242	45	RNAs	rna	NNS
cord-007689-0vpp3xdl	242	46	(	(	-LRB-
cord-007689-0vpp3xdl	242	47	snoRNAs	snoRNAs	NNP
cord-007689-0vpp3xdl	242	48	)	)	-RRB-
cord-007689-0vpp3xdl	242	49	.	.	.
cord-007689-0vpp3xdl	243	1	However	however	RB
cord-007689-0vpp3xdl	243	2	,	,	,
cord-007689-0vpp3xdl	243	3	the	the	DT
cord-007689-0vpp3xdl	243	4	frequency	frequency	NN
cord-007689-0vpp3xdl	243	5	and	and	CC
cord-007689-0vpp3xdl	243	6	location	location	NN
cord-007689-0vpp3xdl	243	7	of	of	IN
cord-007689-0vpp3xdl	243	8	pseudouridinylated	pseudouridinylate	VBN
cord-007689-0vpp3xdl	243	9	nucleotides	nucleotide	NNS
cord-007689-0vpp3xdl	243	10	vary	vary	VBP
cord-007689-0vpp3xdl	243	11	phylogenetically	phylogenetically	RB
cord-007689-0vpp3xdl	243	12	.	.	.
cord-007689-0vpp3xdl	244	1	Intriguingly	intriguingly	RB
cord-007689-0vpp3xdl	244	2	,	,	,
cord-007689-0vpp3xdl	244	3	eukaryotes	eukaryote	NNS
cord-007689-0vpp3xdl	244	4	contain	contain	VBP
cord-007689-0vpp3xdl	244	5	far	far	RB
cord-007689-0vpp3xdl	244	6	more	more	JJR
cord-007689-0vpp3xdl	244	7	nucleoside	nucleoside	NN
cord-007689-0vpp3xdl	244	8	modifications	modification	NNS
cord-007689-0vpp3xdl	244	9	within	within	IN
cord-007689-0vpp3xdl	244	10	their	-PRON-	PRP$
cord-007689-0vpp3xdl	244	11	RNA	RNA	NNP
cord-007689-0vpp3xdl	244	12	species	specie	NNS
cord-007689-0vpp3xdl	244	13	.	.	.
cord-007689-0vpp3xdl	245	1	Human	human	JJ
cord-007689-0vpp3xdl	245	2	ribosomal	ribosomal	NNP
cord-007689-0vpp3xdl	245	3	RNA	RNA	NNP
cord-007689-0vpp3xdl	245	4	,	,	,
cord-007689-0vpp3xdl	245	5	for	for	IN
cord-007689-0vpp3xdl	245	6	example	example	NN
cord-007689-0vpp3xdl	245	7	,	,	,
cord-007689-0vpp3xdl	245	8	the	the	DT
cord-007689-0vpp3xdl	245	9	major	major	JJ
cord-007689-0vpp3xdl	245	10	constituent	constituent	NN
cord-007689-0vpp3xdl	245	11	of	of	IN
cord-007689-0vpp3xdl	245	12	cellular	cellular	JJ
cord-007689-0vpp3xdl	245	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	245	14	,	,	,
cord-007689-0vpp3xdl	245	15	contains	contain	VBZ
cord-007689-0vpp3xdl	245	16	ten	ten	CD
cord-007689-0vpp3xdl	245	17	times	time	NNS
cord-007689-0vpp3xdl	245	18	more	more	JJR
cord-007689-0vpp3xdl	245	19	pseudouridine	pseudouridine	NN
cord-007689-0vpp3xdl	245	20	and	and	CC
cord-007689-0vpp3xdl	245	21	25	25	CD
cord-007689-0vpp3xdl	245	22	times	time	NNS
cord-007689-0vpp3xdl	245	23	more	more	JJR
cord-007689-0vpp3xdl	245	24	2-O	2-o	CD
cord-007689-0vpp3xdl	245	25	-	-	HYPH
cord-007689-0vpp3xdl	245	26	methylated	methylate	VBN
cord-007689-0vpp3xdl	245	27	nucleosides	nucleoside	NNS
cord-007689-0vpp3xdl	245	28	than	than	IN
cord-007689-0vpp3xdl	245	29	E.	E.	NNP
cord-007689-0vpp3xdl	245	30	coli	coli	VBZ
cord-007689-0vpp3xdl	245	31	rRNA	rrna	NN
cord-007689-0vpp3xdl	245	32	(	(	-LRB-
cord-007689-0vpp3xdl	245	33	Rozenski	Rozenski	NNP
cord-007689-0vpp3xdl	245	34	et	et	NNP
cord-007689-0vpp3xdl	245	35	al	al	NNP
cord-007689-0vpp3xdl	245	36	.	.	.
cord-007689-0vpp3xdl	245	37	1999	1999	CD
cord-007689-0vpp3xdl	245	38	)	)	-RRB-
cord-007689-0vpp3xdl	245	39	.	.	.
cord-007689-0vpp3xdl	246	1	The	the	DT
cord-007689-0vpp3xdl	246	2	same	same	JJ
cord-007689-0vpp3xdl	246	3	applies	apply	VBZ
cord-007689-0vpp3xdl	246	4	to	to	IN
cord-007689-0vpp3xdl	246	5	eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	246	6	tRNAs	trna	NNS
cord-007689-0vpp3xdl	246	7	,	,	,
cord-007689-0vpp3xdl	246	8	the	the	DT
cord-007689-0vpp3xdl	246	9	most	most	RBS
cord-007689-0vpp3xdl	246	10	heavily	heavily	RB
cord-007689-0vpp3xdl	246	11	modified	modify	VBN
cord-007689-0vpp3xdl	246	12	subgroup	subgroup	NN
cord-007689-0vpp3xdl	246	13	of	of	IN
cord-007689-0vpp3xdl	246	14	RNA	RNA	NNP
cord-007689-0vpp3xdl	246	15	with	with	IN
cord-007689-0vpp3xdl	246	16	up	up	IN
cord-007689-0vpp3xdl	246	17	to	to	TO
cord-007689-0vpp3xdl	246	18	25	25	CD
cord-007689-0vpp3xdl	246	19	%	%	NN
cord-007689-0vpp3xdl	246	20	of	of	IN
cord-007689-0vpp3xdl	246	21	modified	modify	VBN
cord-007689-0vpp3xdl	246	22	nucleosides	nucleoside	NNS
cord-007689-0vpp3xdl	246	23	.	.	.
cord-007689-0vpp3xdl	247	1	The	the	DT
cord-007689-0vpp3xdl	247	2	host	host	NN
cord-007689-0vpp3xdl	247	3	machinery	machinery	NN
cord-007689-0vpp3xdl	247	4	that	that	WDT
cord-007689-0vpp3xdl	247	5	guides	guide	VBZ
cord-007689-0vpp3xdl	247	6	nucleoside	nucleoside	JJ
cord-007689-0vpp3xdl	247	7	modifications	modification	NNS
cord-007689-0vpp3xdl	247	8	and	and	CC
cord-007689-0vpp3xdl	247	9	2′-O	2′-o	CD
cord-007689-0vpp3xdl	247	10	-	-	HYPH
cord-007689-0vpp3xdl	247	11	methylation	methylation	NN
cord-007689-0vpp3xdl	247	12	of	of	IN
cord-007689-0vpp3xdl	247	13	the	the	DT
cord-007689-0vpp3xdl	247	14	ribose	ribose	NN
cord-007689-0vpp3xdl	247	15	backbone	backbone	NN
cord-007689-0vpp3xdl	247	16	is	be	VBZ
cord-007689-0vpp3xdl	247	17	located	locate	VBN
cord-007689-0vpp3xdl	247	18	in	in	IN
cord-007689-0vpp3xdl	247	19	the	the	DT
cord-007689-0vpp3xdl	247	20	nucleolus	nucleolus	NN
cord-007689-0vpp3xdl	247	21	,	,	,
cord-007689-0vpp3xdl	247	22	and	and	CC
cord-007689-0vpp3xdl	247	23	consists	consist	VBZ
cord-007689-0vpp3xdl	247	24	of	of	IN
cord-007689-0vpp3xdl	247	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	247	26	-	-	HYPH
cord-007689-0vpp3xdl	247	27	protein	protein	NN
cord-007689-0vpp3xdl	247	28	complexes	complex	NNS
cord-007689-0vpp3xdl	247	29	containing	contain	VBG
cord-007689-0vpp3xdl	247	30	snoRNAs	snoRNAs	NNP
cord-007689-0vpp3xdl	247	31	and	and	CC
cord-007689-0vpp3xdl	247	32	several	several	JJ
cord-007689-0vpp3xdl	247	33	associated	associate	VBN
cord-007689-0vpp3xdl	247	34	proteins	protein	NNS
cord-007689-0vpp3xdl	247	35	(	(	-LRB-
cord-007689-0vpp3xdl	247	36	snoRNPs	snornps	RB
cord-007689-0vpp3xdl	247	37	)	)	-RRB-
cord-007689-0vpp3xdl	248	1	(	(	-LRB-
cord-007689-0vpp3xdl	248	2	Decatur	Decatur	NNP
cord-007689-0vpp3xdl	248	3	and	and	CC
cord-007689-0vpp3xdl	248	4	Fournier	Fournier	NNP
cord-007689-0vpp3xdl	248	5	2003	2003	CD
cord-007689-0vpp3xdl	248	6	)	)	-RRB-
cord-007689-0vpp3xdl	248	7	.	.	.
cord-007689-0vpp3xdl	249	1	Information	information	NN
cord-007689-0vpp3xdl	249	2	on	on	IN
cord-007689-0vpp3xdl	249	3	nucleolus	nucleolus	NN
cord-007689-0vpp3xdl	249	4	-	-	HYPH
cord-007689-0vpp3xdl	249	5	specific	specific	JJ
cord-007689-0vpp3xdl	249	6	nucleoside	nucleoside	NN
cord-007689-0vpp3xdl	249	7	modifications	modification	NNS
cord-007689-0vpp3xdl	249	8	or	or	CC
cord-007689-0vpp3xdl	249	9	ribose	ribose	NN
cord-007689-0vpp3xdl	249	10	2′-O	2′-o	CD
cord-007689-0vpp3xdl	249	11	-	-	HYPH
cord-007689-0vpp3xdl	249	12	methylation	methylation	NN
cord-007689-0vpp3xdl	249	13	of	of	IN
cord-007689-0vpp3xdl	249	14	viral	viral	JJ
cord-007689-0vpp3xdl	249	15	RNA	RNA	NNP
cord-007689-0vpp3xdl	249	16	genomes	genome	NNS
cord-007689-0vpp3xdl	249	17	is	be	VBZ
cord-007689-0vpp3xdl	249	18	limited	limited	JJ
cord-007689-0vpp3xdl	249	19	.	.	.
cord-007689-0vpp3xdl	250	1	Since	since	IN
cord-007689-0vpp3xdl	250	2	most	most	JJS
cord-007689-0vpp3xdl	250	3	RNA	RNA	NNP
cord-007689-0vpp3xdl	250	4	viruses	virus	NNS
cord-007689-0vpp3xdl	250	5	do	do	VBP
cord-007689-0vpp3xdl	250	6	not	not	RB
cord-007689-0vpp3xdl	250	7	replicate	replicate	VB
cord-007689-0vpp3xdl	250	8	in	in	IN
cord-007689-0vpp3xdl	250	9	the	the	DT
cord-007689-0vpp3xdl	250	10	nucleus	nucleus	NN
cord-007689-0vpp3xdl	250	11	and	and	CC
cord-007689-0vpp3xdl	250	12	modification	modification	NN
cord-007689-0vpp3xdl	250	13	is	be	VBZ
cord-007689-0vpp3xdl	250	14	tightly	tightly	RB
cord-007689-0vpp3xdl	250	15	confined	confine	VBN
cord-007689-0vpp3xdl	250	16	to	to	IN
cord-007689-0vpp3xdl	250	17	the	the	DT
cord-007689-0vpp3xdl	250	18	sequence	sequence	NN
cord-007689-0vpp3xdl	250	19	and	and	CC
cord-007689-0vpp3xdl	250	20	structure	structure	NN
cord-007689-0vpp3xdl	250	21	of	of	IN
cord-007689-0vpp3xdl	250	22	their	-PRON-	PRP$
cord-007689-0vpp3xdl	250	23	target	target	NN
cord-007689-0vpp3xdl	250	24	,	,	,
cord-007689-0vpp3xdl	250	25	extensive	extensive	JJ
cord-007689-0vpp3xdl	250	26	modification	modification	NN
cord-007689-0vpp3xdl	250	27	of	of	IN
cord-007689-0vpp3xdl	250	28	viral	viral	JJ
cord-007689-0vpp3xdl	250	29	RNA	RNA	NNP
cord-007689-0vpp3xdl	250	30	seems	seem	VBZ
cord-007689-0vpp3xdl	250	31	unlikely	unlikely	JJ
cord-007689-0vpp3xdl	250	32	.	.	.
cord-007689-0vpp3xdl	251	1	Altogether	altogether	RB
cord-007689-0vpp3xdl	251	2	,	,	,
cord-007689-0vpp3xdl	251	3	post	post	JJ
cord-007689-0vpp3xdl	251	4	-	-	JJ
cord-007689-0vpp3xdl	251	5	transcriptional	transcriptional	JJ
cord-007689-0vpp3xdl	251	6	modifications	modification	NNS
cord-007689-0vpp3xdl	251	7	of	of	IN
cord-007689-0vpp3xdl	251	8	eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	251	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	251	10	such	such	JJ
cord-007689-0vpp3xdl	251	11	as	as	IN
cord-007689-0vpp3xdl	251	12	5′	5′	CD
cord-007689-0vpp3xdl	251	13	processing	processing	NN
cord-007689-0vpp3xdl	251	14	or	or	CC
cord-007689-0vpp3xdl	251	15	capping	capping	NN
cord-007689-0vpp3xdl	251	16	,	,	,
cord-007689-0vpp3xdl	251	17	as	as	RB
cord-007689-0vpp3xdl	251	18	well	well	RB
cord-007689-0vpp3xdl	251	19	as	as	IN
cord-007689-0vpp3xdl	251	20	nucleoside	nucleoside	NN
cord-007689-0vpp3xdl	251	21	modifications	modification	NNS
cord-007689-0vpp3xdl	251	22	or	or	CC
cord-007689-0vpp3xdl	251	23	ribose	ribose	NN
cord-007689-0vpp3xdl	251	24	backbone	backbone	NN
cord-007689-0vpp3xdl	251	25	methylation	methylation	NN
cord-007689-0vpp3xdl	251	26	,	,	,
cord-007689-0vpp3xdl	251	27	provide	provide	VB
cord-007689-0vpp3xdl	251	28	the	the	DT
cord-007689-0vpp3xdl	251	29	molecular	molecular	JJ
cord-007689-0vpp3xdl	251	30	basis	basis	NN
cord-007689-0vpp3xdl	251	31	for	for	IN
cord-007689-0vpp3xdl	251	32	the	the	DT
cord-007689-0vpp3xdl	251	33	distinction	distinction	NN
cord-007689-0vpp3xdl	251	34	of	of	IN
cord-007689-0vpp3xdl	251	35	self	self	NN
cord-007689-0vpp3xdl	251	36	-	-	HYPH
cord-007689-0vpp3xdl	251	37	RNA	RNA	NNP
cord-007689-0vpp3xdl	251	38	generated	generate	VBN
cord-007689-0vpp3xdl	251	39	in	in	IN
cord-007689-0vpp3xdl	251	40	the	the	DT
cord-007689-0vpp3xdl	251	41	nucleus	nucleus	NN
cord-007689-0vpp3xdl	251	42	from	from	IN
cord-007689-0vpp3xdl	251	43	viral	viral	JJ
cord-007689-0vpp3xdl	251	44	RNA	RNA	NNP
cord-007689-0vpp3xdl	251	45	of	of	IN
cord-007689-0vpp3xdl	251	46	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	251	47	origin	origin	NN
cord-007689-0vpp3xdl	251	48	containing	contain	VBG
cord-007689-0vpp3xdl	251	49	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	251	50	(	(	-LRB-
cord-007689-0vpp3xdl	251	51	3pRNA	3prna	CD
cord-007689-0vpp3xdl	251	52	)	)	-RRB-
cord-007689-0vpp3xdl	251	53	.	.	.
cord-007689-0vpp3xdl	252	1	The	the	DT
cord-007689-0vpp3xdl	252	2	mRNAs	mrna	NNS
cord-007689-0vpp3xdl	252	3	of	of	IN
cord-007689-0vpp3xdl	252	4	viruses	virus	NNS
cord-007689-0vpp3xdl	252	5	infecting	infect	VBG
cord-007689-0vpp3xdl	252	6	eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	252	7	cells	cell	NNS
cord-007689-0vpp3xdl	252	8	also	also	RB
cord-007689-0vpp3xdl	252	9	commonly	commonly	RB
cord-007689-0vpp3xdl	252	10	contain	contain	VBP
cord-007689-0vpp3xdl	252	11	7-methyl	7-methyl	CD
cord-007689-0vpp3xdl	252	12	guanosine	guanosine	NN
cord-007689-0vpp3xdl	252	13	cap	cap	NN
cord-007689-0vpp3xdl	252	14	-	-	HYPH
cord-007689-0vpp3xdl	252	15	structures	structure	NNS
cord-007689-0vpp3xdl	252	16	at	at	IN
cord-007689-0vpp3xdl	252	17	their	-PRON-	PRP$
cord-007689-0vpp3xdl	252	18	5′	5′	CD
cord-007689-0vpp3xdl	252	19	ends	end	NNS
cord-007689-0vpp3xdl	252	20	and	and	CC
cord-007689-0vpp3xdl	252	21	poly(A	poly(a	JJ
cord-007689-0vpp3xdl	252	22	)	)	-RRB-
cord-007689-0vpp3xdl	253	1	tails	tail	NNS
cord-007689-0vpp3xdl	253	2	at	at	IN
cord-007689-0vpp3xdl	253	3	their	-PRON-	PRP$
cord-007689-0vpp3xdl	253	4	3′ends	3′ends	CD
cord-007689-0vpp3xdl	253	5	(	(	-LRB-
cord-007689-0vpp3xdl	253	6	Furuichi	Furuichi	NNP
cord-007689-0vpp3xdl	253	7	and	and	CC
cord-007689-0vpp3xdl	253	8	Shatkin	Shatkin	NNP
cord-007689-0vpp3xdl	253	9	2000	2000	CD
cord-007689-0vpp3xdl	253	10	)	)	-RRB-
cord-007689-0vpp3xdl	253	11	.	.	.
cord-007689-0vpp3xdl	254	1	Some	some	DT
cord-007689-0vpp3xdl	254	2	viruses	virus	NNS
cord-007689-0vpp3xdl	254	3	make	make	VBP
cord-007689-0vpp3xdl	254	4	use	use	NN
cord-007689-0vpp3xdl	254	5	of	of	IN
cord-007689-0vpp3xdl	254	6	the	the	DT
cord-007689-0vpp3xdl	254	7	host	host	NN
cord-007689-0vpp3xdl	254	8	transcription	transcription	NN
cord-007689-0vpp3xdl	254	9	machinery	machinery	NN
cord-007689-0vpp3xdl	254	10	to	to	TO
cord-007689-0vpp3xdl	254	11	acquire	acquire	VB
cord-007689-0vpp3xdl	254	12	caps	cap	NNS
cord-007689-0vpp3xdl	254	13	and	and	CC
cord-007689-0vpp3xdl	254	14	poly(A	poly(a	JJ
cord-007689-0vpp3xdl	254	15	)	)	-RRB-
cord-007689-0vpp3xdl	254	16	tails	tail	NNS
cord-007689-0vpp3xdl	254	17	.	.	.
cord-007689-0vpp3xdl	255	1	RNA	RNA	NNP
cord-007689-0vpp3xdl	255	2	viruses	virus	NNS
cord-007689-0vpp3xdl	255	3	that	that	WDT
cord-007689-0vpp3xdl	255	4	do	do	VBP
cord-007689-0vpp3xdl	255	5	not	not	RB
cord-007689-0vpp3xdl	255	6	rely	rely	VB
cord-007689-0vpp3xdl	255	7	on	on	IN
cord-007689-0vpp3xdl	255	8	the	the	DT
cord-007689-0vpp3xdl	255	9	host	host	NN
cord-007689-0vpp3xdl	255	10	transcriptional	transcriptional	JJ
cord-007689-0vpp3xdl	255	11	machinery	machinery	NN
cord-007689-0vpp3xdl	255	12	produce	produce	VBP
cord-007689-0vpp3xdl	255	13	their	-PRON-	PRP$
cord-007689-0vpp3xdl	255	14	own	own	JJ
cord-007689-0vpp3xdl	255	15	capping	cap	VBG
cord-007689-0vpp3xdl	255	16	enzymes	enzyme	NNS
cord-007689-0vpp3xdl	255	17	or	or	CC
cord-007689-0vpp3xdl	255	18	utilize	utilize	VBP
cord-007689-0vpp3xdl	255	19	other	other	JJ
cord-007689-0vpp3xdl	255	20	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	255	21	such	such	JJ
cord-007689-0vpp3xdl	255	22	as	as	IN
cord-007689-0vpp3xdl	255	23	snatching	snatch	VBG
cord-007689-0vpp3xdl	255	24	the	the	DT
cord-007689-0vpp3xdl	255	25	5′terminal	5′terminal	CD
cord-007689-0vpp3xdl	255	26	regions	region	NNS
cord-007689-0vpp3xdl	255	27	of	of	IN
cord-007689-0vpp3xdl	255	28	host	host	NN
cord-007689-0vpp3xdl	255	29	mRNAs	mrnas	CD
cord-007689-0vpp3xdl	255	30	.	.	.
cord-007689-0vpp3xdl	256	1	Despite	despite	IN
cord-007689-0vpp3xdl	256	2	these	these	DT
cord-007689-0vpp3xdl	256	3	adaptations	adaptation	NNS
cord-007689-0vpp3xdl	256	4	of	of	IN
cord-007689-0vpp3xdl	256	5	viruses	virus	NNS
cord-007689-0vpp3xdl	256	6	to	to	IN
cord-007689-0vpp3xdl	256	7	the	the	DT
cord-007689-0vpp3xdl	256	8	host	host	NN
cord-007689-0vpp3xdl	256	9	transcriptional	transcriptional	NN
cord-007689-0vpp3xdl	256	10	system	system	NN
cord-007689-0vpp3xdl	256	11	,	,	,
cord-007689-0vpp3xdl	256	12	viral	viral	JJ
cord-007689-0vpp3xdl	256	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	256	14	synthesis	synthesis	NN
cord-007689-0vpp3xdl	256	15	leads	lead	VBZ
cord-007689-0vpp3xdl	256	16	to	to	IN
cord-007689-0vpp3xdl	256	17	transient	transient	JJ
cord-007689-0vpp3xdl	256	18	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	256	19	RNA	RNA	NNP
cord-007689-0vpp3xdl	256	20	intermediates	intermediate	NNS
cord-007689-0vpp3xdl	256	21	with	with	IN
cord-007689-0vpp3xdl	256	22	an	an	DT
cord-007689-0vpp3xdl	256	23	uncapped	uncapped	JJ
cord-007689-0vpp3xdl	256	24	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	256	25	end	end	NN
cord-007689-0vpp3xdl	256	26	.	.	.
cord-007689-0vpp3xdl	257	1	With	with	IN
cord-007689-0vpp3xdl	257	2	notable	notable	JJ
cord-007689-0vpp3xdl	257	3	exceptions	exception	NNS
cord-007689-0vpp3xdl	257	4	such	such	JJ
cord-007689-0vpp3xdl	257	5	as	as	IN
cord-007689-0vpp3xdl	257	6	the	the	DT
cord-007689-0vpp3xdl	257	7	Picornavirus	Picornavirus	NNP
cord-007689-0vpp3xdl	257	8	family	family	NN
cord-007689-0vpp3xdl	257	9	(	(	-LRB-
cord-007689-0vpp3xdl	257	10	see	see	VB
cord-007689-0vpp3xdl	257	11	below	below	RB
cord-007689-0vpp3xdl	257	12	)	)	-RRB-
cord-007689-0vpp3xdl	257	13	,	,	,
cord-007689-0vpp3xdl	257	14	viral	viral	JJ
cord-007689-0vpp3xdl	257	15	RNA	RNA	NNP
cord-007689-0vpp3xdl	257	16	-	-	HYPH
cord-007689-0vpp3xdl	257	17	dependent	dependent	JJ
cord-007689-0vpp3xdl	257	18	RNA	RNA	NNP
cord-007689-0vpp3xdl	257	19	polymerases	polymerase	NNS
cord-007689-0vpp3xdl	257	20	(	(	-LRB-
cord-007689-0vpp3xdl	257	21	RdRp	RdRp	NNP
cord-007689-0vpp3xdl	257	22	)	)	-RRB-
cord-007689-0vpp3xdl	257	23	initiate	initiate	VB
cord-007689-0vpp3xdl	257	24	polymerase	polymerase	NN
cord-007689-0vpp3xdl	257	25	activity	activity	NN
cord-007689-0vpp3xdl	257	26	de	de	NNP
cord-007689-0vpp3xdl	257	27	novo	novo	NNP
cord-007689-0vpp3xdl	257	28	,	,	,
cord-007689-0vpp3xdl	257	29	without	without	IN
cord-007689-0vpp3xdl	257	30	a	a	DT
cord-007689-0vpp3xdl	257	31	specific	specific	JJ
cord-007689-0vpp3xdl	257	32	primer	primer	NN
cord-007689-0vpp3xdl	257	33	(	(	-LRB-
cord-007689-0vpp3xdl	257	34	Kao	Kao	NNP
cord-007689-0vpp3xdl	257	35	et	et	FW
cord-007689-0vpp3xdl	257	36	al	al	NNP
cord-007689-0vpp3xdl	257	37	.	.	NNP
cord-007689-0vpp3xdl	257	38	2001	2001	CD
cord-007689-0vpp3xdl	257	39	)	)	-RRB-
cord-007689-0vpp3xdl	257	40	.	.	.
cord-007689-0vpp3xdl	258	1	As	as	IN
cord-007689-0vpp3xdl	258	2	a	a	DT
cord-007689-0vpp3xdl	258	3	consequence	consequence	NN
cord-007689-0vpp3xdl	258	4	,	,	,
cord-007689-0vpp3xdl	258	5	these	these	DT
cord-007689-0vpp3xdl	258	6	RdRp	rdrp	NN
cord-007689-0vpp3xdl	258	7	-	-	HYPH
cord-007689-0vpp3xdl	258	8	dependent	dependent	JJ
cord-007689-0vpp3xdl	258	9	transcripts	transcript	NNS
cord-007689-0vpp3xdl	258	10	start	start	VBP
cord-007689-0vpp3xdl	258	11	with	with	IN
cord-007689-0vpp3xdl	258	12	an	an	DT
cord-007689-0vpp3xdl	258	13	uncapped	uncapped	JJ
cord-007689-0vpp3xdl	258	14	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	258	15	.	.	.
cord-007689-0vpp3xdl	259	1	This	this	DT
cord-007689-0vpp3xdl	259	2	has	have	VBZ
cord-007689-0vpp3xdl	259	3	been	be	VBN
cord-007689-0vpp3xdl	259	4	studied	study	VBN
cord-007689-0vpp3xdl	259	5	in	in	IN
cord-007689-0vpp3xdl	259	6	great	great	JJ
cord-007689-0vpp3xdl	259	7	detail	detail	NN
cord-007689-0vpp3xdl	259	8	for	for	IN
cord-007689-0vpp3xdl	259	9	the	the	DT
cord-007689-0vpp3xdl	259	10	replication	replication	NN
cord-007689-0vpp3xdl	259	11	of	of	IN
cord-007689-0vpp3xdl	259	12	positive	positive	JJ
cord-007689-0vpp3xdl	259	13	-	-	HYPH
cord-007689-0vpp3xdl	259	14	strand	strand	NN
cord-007689-0vpp3xdl	259	15	RNA	RNA	NNP
cord-007689-0vpp3xdl	259	16	viruses	virus	NNS
cord-007689-0vpp3xdl	259	17	of	of	IN
cord-007689-0vpp3xdl	259	18	the	the	DT
cord-007689-0vpp3xdl	259	19	family	family	NN
cord-007689-0vpp3xdl	259	20	of	of	IN
cord-007689-0vpp3xdl	259	21	Flaviviridae	Flaviviridae	NNP
cord-007689-0vpp3xdl	259	22	(	(	-LRB-
cord-007689-0vpp3xdl	259	23	including	include	VBG
cord-007689-0vpp3xdl	259	24	the	the	DT
cord-007689-0vpp3xdl	259	25	genera	genera	NNP
cord-007689-0vpp3xdl	259	26	Flavivirus	Flavivirus	NNP
cord-007689-0vpp3xdl	259	27	,	,	,
cord-007689-0vpp3xdl	259	28	Pestivirus	Pestivirus	NNP
cord-007689-0vpp3xdl	259	29	,	,	,
cord-007689-0vpp3xdl	259	30	and	and	CC
cord-007689-0vpp3xdl	259	31	Hepacivirus	Hepacivirus	NNP
cord-007689-0vpp3xdl	259	32	)	)	-RRB-
cord-007689-0vpp3xdl	259	33	;	;	:
cord-007689-0vpp3xdl	259	34	members	member	NNS
cord-007689-0vpp3xdl	259	35	of	of	IN
cord-007689-0vpp3xdl	259	36	all	all	DT
cord-007689-0vpp3xdl	259	37	of	of	IN
cord-007689-0vpp3xdl	259	38	these	these	DT
cord-007689-0vpp3xdl	259	39	virus	virus	NN
cord-007689-0vpp3xdl	259	40	genera	genus	NNS
cord-007689-0vpp3xdl	259	41	were	be	VBD
cord-007689-0vpp3xdl	259	42	reported	report	VBN
cord-007689-0vpp3xdl	259	43	as	as	IN
cord-007689-0vpp3xdl	259	44	being	be	VBG
cord-007689-0vpp3xdl	259	45	recognized	recognize	VBN
cord-007689-0vpp3xdl	259	46	via	via	IN
cord-007689-0vpp3xdl	259	47	RIG	rig	NN
cord-007689-0vpp3xdl	259	48	-	-	:
cord-007689-0vpp3xdl	259	49	I	i	NN
cord-007689-0vpp3xdl	259	50	(	(	-LRB-
cord-007689-0vpp3xdl	259	51	Honda	Honda	NNP
cord-007689-0vpp3xdl	259	52	et	et	NNP
cord-007689-0vpp3xdl	259	53	al	al	NNP
cord-007689-0vpp3xdl	259	54	.	.	.
cord-007689-0vpp3xdl	260	1	1998	1998	CD
cord-007689-0vpp3xdl	260	2	;	;	:
cord-007689-0vpp3xdl	260	3	Kato	Kato	NNP
cord-007689-0vpp3xdl	260	4	et	et	NNP
cord-007689-0vpp3xdl	260	5	al	al	NNP
cord-007689-0vpp3xdl	260	6	.	.	.
cord-007689-0vpp3xdl	261	1	2006	2006	CD
cord-007689-0vpp3xdl	261	2	;	;	:
cord-007689-0vpp3xdl	261	3	Sumpter	Sumpter	NNP
cord-007689-0vpp3xdl	261	4	et	et	NNP
cord-007689-0vpp3xdl	261	5	al	al	NNP
cord-007689-0vpp3xdl	261	6	.	.	NNP
cord-007689-0vpp3xdl	261	7	2005	2005	CD
cord-007689-0vpp3xdl	261	8	)	)	-RRB-
cord-007689-0vpp3xdl	261	9	.	.	.
cord-007689-0vpp3xdl	262	1	Segmented	segmented	JJ
cord-007689-0vpp3xdl	262	2	NSV	NSV	NNP
cord-007689-0vpp3xdl	262	3	rely	rely	VBP
cord-007689-0vpp3xdl	262	4	on	on	IN
cord-007689-0vpp3xdl	262	5	a	a	DT
cord-007689-0vpp3xdl	262	6	cap	cap	NN
cord-007689-0vpp3xdl	262	7	-	-	HYPH
cord-007689-0vpp3xdl	262	8	snatched	snatch	VBN
cord-007689-0vpp3xdl	262	9	primer	primer	NN
cord-007689-0vpp3xdl	262	10	for	for	IN
cord-007689-0vpp3xdl	262	11	mRNA	mRNA	NNP
cord-007689-0vpp3xdl	262	12	transcription	transcription	NN
cord-007689-0vpp3xdl	262	13	,	,	,
cord-007689-0vpp3xdl	262	14	yet	yet	CC
cord-007689-0vpp3xdl	262	15	initiate	initiate	VB
cord-007689-0vpp3xdl	262	16	genomic	genomic	JJ
cord-007689-0vpp3xdl	262	17	and	and	CC
cord-007689-0vpp3xdl	262	18	the	the	DT
cord-007689-0vpp3xdl	262	19	complementary	complementary	JJ
cord-007689-0vpp3xdl	262	20	antigenomic	antigenomic	NNP
cord-007689-0vpp3xdl	262	21	RNA	RNA	NNP
cord-007689-0vpp3xdl	262	22	replication	replication	NN
cord-007689-0vpp3xdl	262	23	by	by	IN
cord-007689-0vpp3xdl	262	24	a	a	DT
cord-007689-0vpp3xdl	262	25	primer	primer	NN
cord-007689-0vpp3xdl	262	26	-	-	HYPH
cord-007689-0vpp3xdl	262	27	independent	independent	JJ
cord-007689-0vpp3xdl	262	28	de	de	FW
cord-007689-0vpp3xdl	262	29	novo	novo	NNP
cord-007689-0vpp3xdl	262	30	mechanism	mechanism	NN
cord-007689-0vpp3xdl	262	31	resulting	result	VBG
cord-007689-0vpp3xdl	262	32	in	in	IN
cord-007689-0vpp3xdl	262	33	a	a	DT
cord-007689-0vpp3xdl	262	34	5′-triphosphateinitiated	5′-triphosphateinitiated	CD
cord-007689-0vpp3xdl	262	35	transcript	transcript	NN
cord-007689-0vpp3xdl	262	36	(	(	-LRB-
cord-007689-0vpp3xdl	262	37	Honda	Honda	NNP
cord-007689-0vpp3xdl	262	38	et	et	NNP
cord-007689-0vpp3xdl	262	39	al	al	NNP
cord-007689-0vpp3xdl	262	40	.	.	NNP
cord-007689-0vpp3xdl	262	41	1998	1998	CD
cord-007689-0vpp3xdl	262	42	;	;	:
cord-007689-0vpp3xdl	262	43	Neumann	Neumann	NNP
cord-007689-0vpp3xdl	262	44	et	et	NNP
cord-007689-0vpp3xdl	262	45	al	al	NNP
cord-007689-0vpp3xdl	262	46	.	.	.
cord-007689-0vpp3xdl	262	47	2004	2004	CD
cord-007689-0vpp3xdl	262	48	)	)	-RRB-
cord-007689-0vpp3xdl	262	49	.	.	.
cord-007689-0vpp3xdl	263	1	NSV	NSV	NNP
cord-007689-0vpp3xdl	263	2	with	with	IN
cord-007689-0vpp3xdl	263	3	a	a	DT
cord-007689-0vpp3xdl	263	4	nonsegmented	nonsegmente	VBN
cord-007689-0vpp3xdl	263	5	genome	genome	NN
cord-007689-0vpp3xdl	263	6	(	(	-LRB-
cord-007689-0vpp3xdl	263	7	order	order	NN
cord-007689-0vpp3xdl	263	8	Mononegavirales	Mononegavirales	NNP
cord-007689-0vpp3xdl	263	9	)	)	-RRB-
cord-007689-0vpp3xdl	263	10	,	,	,
cord-007689-0vpp3xdl	263	11	including	include	VBG
cord-007689-0vpp3xdl	263	12	the	the	DT
cord-007689-0vpp3xdl	263	13	Paramyxoviruses	Paramyxoviruses	NNPS
cord-007689-0vpp3xdl	263	14	and	and	CC
cord-007689-0vpp3xdl	263	15	Rhabdoviruses	Rhabdoviruses	NNPS
cord-007689-0vpp3xdl	263	16	,	,	,
cord-007689-0vpp3xdl	263	17	initiate	initiate	VB
cord-007689-0vpp3xdl	263	18	both	both	DT
cord-007689-0vpp3xdl	263	19	replication	replication	NN
cord-007689-0vpp3xdl	263	20	and	and	CC
cord-007689-0vpp3xdl	263	21	transcription	transcription	NN
cord-007689-0vpp3xdl	263	22	de	de	NNP
cord-007689-0vpp3xdl	263	23	novo	novo	NNP
cord-007689-0vpp3xdl	263	24	leading	lead	VBG
cord-007689-0vpp3xdl	263	25	to	to	IN
cord-007689-0vpp3xdl	263	26	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	263	27	RNA	RNA	NNP
cord-007689-0vpp3xdl	263	28	in	in	IN
cord-007689-0vpp3xdl	263	29	the	the	DT
cord-007689-0vpp3xdl	263	30	cytosol	cytosol	NN
cord-007689-0vpp3xdl	263	31	.	.	.
cord-007689-0vpp3xdl	264	1	Both	both	DT
cord-007689-0vpp3xdl	264	2	the	the	DT
cord-007689-0vpp3xdl	264	3	full	full	JJ
cord-007689-0vpp3xdl	264	4	-	-	HYPH
cord-007689-0vpp3xdl	264	5	length	length	NN
cord-007689-0vpp3xdl	264	6	replication	replication	NN
cord-007689-0vpp3xdl	264	7	products	product	NNS
cord-007689-0vpp3xdl	264	8	,	,	,
cord-007689-0vpp3xdl	264	9	vRNA	vrna	JJ
cord-007689-0vpp3xdl	264	10	and	and	CC
cord-007689-0vpp3xdl	264	11	cRNA	cRNA	NNS
cord-007689-0vpp3xdl	264	12	,	,	,
cord-007689-0vpp3xdl	264	13	and	and	CC
cord-007689-0vpp3xdl	264	14	a	a	DT
cord-007689-0vpp3xdl	264	15	short	short	JJ
cord-007689-0vpp3xdl	264	16	leader	leader	NN
cord-007689-0vpp3xdl	264	17	RNA	RNA	NNP
cord-007689-0vpp3xdl	264	18	,	,	,
cord-007689-0vpp3xdl	264	19	which	which	WDT
cord-007689-0vpp3xdl	264	20	is	be	VBZ
cord-007689-0vpp3xdl	264	21	abundantly	abundantly	RB
cord-007689-0vpp3xdl	264	22	synthesized	synthesize	VBN
cord-007689-0vpp3xdl	264	23	during	during	IN
cord-007689-0vpp3xdl	264	24	initiation	initiation	NN
cord-007689-0vpp3xdl	264	25	of	of	IN
cord-007689-0vpp3xdl	264	26	transcription	transcription	NN
cord-007689-0vpp3xdl	264	27	,	,	,
cord-007689-0vpp3xdl	264	28	maintain	maintain	VBP
cord-007689-0vpp3xdl	264	29	their	-PRON-	PRP$
cord-007689-0vpp3xdl	264	30	5′triphosphate	5′triphosphate	CD
cord-007689-0vpp3xdl	264	31	(	(	-LRB-
cord-007689-0vpp3xdl	264	32	Colonno	Colonno	NNP
cord-007689-0vpp3xdl	264	33	and	and	CC
cord-007689-0vpp3xdl	264	34	Banerjee	Banerjee	NNP
cord-007689-0vpp3xdl	264	35	1978	1978	CD
cord-007689-0vpp3xdl	264	36	;	;	:
cord-007689-0vpp3xdl	264	37	Whelan	Whelan	NNP
cord-007689-0vpp3xdl	264	38	et	et	NNP
cord-007689-0vpp3xdl	264	39	al	al	NNP
cord-007689-0vpp3xdl	264	40	.	.	.
cord-007689-0vpp3xdl	264	41	2004	2004	CD
cord-007689-0vpp3xdl	264	42	)	)	-RRB-
cord-007689-0vpp3xdl	264	43	,	,	,
cord-007689-0vpp3xdl	264	44	while	while	IN
cord-007689-0vpp3xdl	264	45	the	the	DT
cord-007689-0vpp3xdl	264	46	virus	virus	NN
cord-007689-0vpp3xdl	264	47	-	-	HYPH
cord-007689-0vpp3xdl	264	48	encoded	encode	VBN
cord-007689-0vpp3xdl	264	49	mRNA	mRNA	NNP
cord-007689-0vpp3xdl	264	50	transcripts	transcript	NNS
cord-007689-0vpp3xdl	264	51	are	be	VBP
cord-007689-0vpp3xdl	264	52	further	further	RB
cord-007689-0vpp3xdl	264	53	modified	modify	VBN
cord-007689-0vpp3xdl	264	54	at	at	IN
cord-007689-0vpp3xdl	264	55	their	-PRON-	PRP$
cord-007689-0vpp3xdl	264	56	5′	5′	CD
cord-007689-0vpp3xdl	264	57	ends	end	NNS
cord-007689-0vpp3xdl	264	58	by	by	IN
cord-007689-0vpp3xdl	264	59	capping	cap	VBG
cord-007689-0vpp3xdl	264	60	and	and	CC
cord-007689-0vpp3xdl	264	61	cap	cap	NN
cord-007689-0vpp3xdl	264	62	methylation	methylation	NN
cord-007689-0vpp3xdl	264	63	.	.	.
cord-007689-0vpp3xdl	265	1	Consequently	consequently	RB
cord-007689-0vpp3xdl	265	2	,	,	,
cord-007689-0vpp3xdl	265	3	genomic	genomic	JJ
cord-007689-0vpp3xdl	265	4	RNA	RNA	NNP
cord-007689-0vpp3xdl	265	5	from	from	IN
cord-007689-0vpp3xdl	265	6	NSVs	nsv	NNS
cord-007689-0vpp3xdl	265	7	per	per	IN
cord-007689-0vpp3xdl	265	8	se	se	FW
cord-007689-0vpp3xdl	265	9	is	be	VBZ
cord-007689-0vpp3xdl	265	10	expected	expect	VBN
cord-007689-0vpp3xdl	265	11	to	to	TO
cord-007689-0vpp3xdl	265	12	trigger	trigger	VB
cord-007689-0vpp3xdl	265	13	an	an	DT
cord-007689-0vpp3xdl	265	14	IFN	IFN	NNP
cord-007689-0vpp3xdl	265	15	-	-	HYPH
cord-007689-0vpp3xdl	265	16	response	response	NN
cord-007689-0vpp3xdl	265	17	without	without	IN
cord-007689-0vpp3xdl	265	18	the	the	DT
cord-007689-0vpp3xdl	265	19	need	need	NN
cord-007689-0vpp3xdl	265	20	for	for	IN
cord-007689-0vpp3xdl	265	21	replication	replication	NN
cord-007689-0vpp3xdl	265	22	and	and	CC
cord-007689-0vpp3xdl	265	23	presumed	presume	VBN
cord-007689-0vpp3xdl	265	24	dsRNA	dsrna	JJ
cord-007689-0vpp3xdl	265	25	formation	formation	NN
cord-007689-0vpp3xdl	265	26	.	.	.
cord-007689-0vpp3xdl	266	1	Consistent	consistent	JJ
cord-007689-0vpp3xdl	266	2	with	with	IN
cord-007689-0vpp3xdl	266	3	this	this	DT
cord-007689-0vpp3xdl	266	4	notion	notion	NN
cord-007689-0vpp3xdl	266	5	,	,	,
cord-007689-0vpp3xdl	266	6	not	not	RB
cord-007689-0vpp3xdl	266	7	only	only	RB
cord-007689-0vpp3xdl	266	8	live	live	VBP
cord-007689-0vpp3xdl	266	9	virus	virus	NN
cord-007689-0vpp3xdl	266	10	but	but	CC
cord-007689-0vpp3xdl	266	11	also	also	RB
cord-007689-0vpp3xdl	266	12	RNA	RNA	NNP
cord-007689-0vpp3xdl	266	13	purified	purify	VBN
cord-007689-0vpp3xdl	266	14	from	from	IN
cord-007689-0vpp3xdl	266	15	NSV	NSV	NNP
cord-007689-0vpp3xdl	266	16	virions	virion	NNS
cord-007689-0vpp3xdl	266	17	(	(	-LRB-
cord-007689-0vpp3xdl	266	18	VSV	VSV	NNP
cord-007689-0vpp3xdl	266	19	)	)	-RRB-
cord-007689-0vpp3xdl	266	20	has	have	VBZ
cord-007689-0vpp3xdl	266	21	been	be	VBN
cord-007689-0vpp3xdl	266	22	shown	show	VBN
cord-007689-0vpp3xdl	266	23	to	to	TO
cord-007689-0vpp3xdl	266	24	trigger	trigger	VB
cord-007689-0vpp3xdl	266	25	strong	strong	JJ
cord-007689-0vpp3xdl	266	26	type	type	NN
cord-007689-0vpp3xdl	267	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	267	2	interferon	interferon	NN
cord-007689-0vpp3xdl	267	3	responses	response	NNS
cord-007689-0vpp3xdl	267	4	depending	depend	VBG
cord-007689-0vpp3xdl	267	5	on	on	IN
cord-007689-0vpp3xdl	267	6	RIG	rig	NN
cord-007689-0vpp3xdl	267	7	-	-	:
cord-007689-0vpp3xdl	267	8	I	i	NN
cord-007689-0vpp3xdl	267	9	)	)	-RRB-
cord-007689-0vpp3xdl	267	10	.	.	.
cord-007689-0vpp3xdl	268	1	Hornung	hornung	NN
cord-007689-0vpp3xdl	268	2	and	and	CC
cord-007689-0vpp3xdl	268	3	colleagues	colleague	NNS
cord-007689-0vpp3xdl	268	4	confirmed	confirm	VBD
cord-007689-0vpp3xdl	268	5	and	and	CC
cord-007689-0vpp3xdl	268	6	extended	extend	VBD
cord-007689-0vpp3xdl	268	7	these	these	DT
cord-007689-0vpp3xdl	268	8	observations	observation	NNS
cord-007689-0vpp3xdl	268	9	by	by	IN
cord-007689-0vpp3xdl	268	10	demonstrating	demonstrate	VBG
cord-007689-0vpp3xdl	268	11	that	that	DT
cord-007689-0vpp3xdl	268	12	dephosphorylation	dephosphorylation	NN
cord-007689-0vpp3xdl	268	13	of	of	IN
cord-007689-0vpp3xdl	268	14	the	the	DT
cord-007689-0vpp3xdl	268	15	viral	viral	JJ
cord-007689-0vpp3xdl	268	16	RNA	RNA	NNP
cord-007689-0vpp3xdl	268	17	isolates	isolate	NNS
cord-007689-0vpp3xdl	268	18	completely	completely	RB
cord-007689-0vpp3xdl	268	19	abolished	abolish	VBD
cord-007689-0vpp3xdl	268	20	the	the	DT
cord-007689-0vpp3xdl	268	21	IFN	IFN	NNP
cord-007689-0vpp3xdl	268	22	-	-	HYPH
cord-007689-0vpp3xdl	268	23	response	response	NN
cord-007689-0vpp3xdl	268	24	,	,	,
cord-007689-0vpp3xdl	268	25	thereby	thereby	RB
cord-007689-0vpp3xdl	268	26	indicating	indicate	VBG
cord-007689-0vpp3xdl	268	27	that	that	IN
cord-007689-0vpp3xdl	268	28	the	the	DT
cord-007689-0vpp3xdl	268	29	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	268	30	moiety	moiety	NN
cord-007689-0vpp3xdl	268	31	is	be	VBZ
cord-007689-0vpp3xdl	268	32	strictly	strictly	RB
cord-007689-0vpp3xdl	268	33	required	require	VBN
cord-007689-0vpp3xdl	268	34	for	for	IN
cord-007689-0vpp3xdl	268	35	recognition	recognition	NN
cord-007689-0vpp3xdl	268	36	.	.	.
cord-007689-0vpp3xdl	269	1	A	a	DT
cord-007689-0vpp3xdl	269	2	notable	notable	JJ
cord-007689-0vpp3xdl	269	3	exception	exception	NN
cord-007689-0vpp3xdl	269	4	are	be	VBP
cord-007689-0vpp3xdl	269	5	the	the	DT
cord-007689-0vpp3xdl	269	6	viruses	virus	NNS
cord-007689-0vpp3xdl	269	7	in	in	IN
cord-007689-0vpp3xdl	269	8	the	the	DT
cord-007689-0vpp3xdl	269	9	Picornavirus	Picornavirus	NNP
cord-007689-0vpp3xdl	269	10	-	-	HYPH
cord-007689-0vpp3xdl	269	11	like	like	JJ
cord-007689-0vpp3xdl	269	12	supergroup	supergroup	NN
cord-007689-0vpp3xdl	269	13	(	(	-LRB-
cord-007689-0vpp3xdl	269	14	picornavirus	picornavirus	NNP
cord-007689-0vpp3xdl	269	15	,	,	,
cord-007689-0vpp3xdl	269	16	potyvirus	potyvirus	NNP
cord-007689-0vpp3xdl	269	17	,	,	,
cord-007689-0vpp3xdl	269	18	comovirus	comovirus	NNP
cord-007689-0vpp3xdl	269	19	,	,	,
cord-007689-0vpp3xdl	269	20	calicivirus	calicivirus	NNP
cord-007689-0vpp3xdl	269	21	,	,	,
cord-007689-0vpp3xdl	269	22	and	and	CC
cord-007689-0vpp3xdl	269	23	other	other	JJ
cord-007689-0vpp3xdl	269	24	viruses	virus	NNS
cord-007689-0vpp3xdl	269	25	)	)	-RRB-
cord-007689-0vpp3xdl	269	26	,	,	,
cord-007689-0vpp3xdl	269	27	which	which	WDT
cord-007689-0vpp3xdl	269	28	exclusively	exclusively	RB
cord-007689-0vpp3xdl	269	29	employs	employ	VBZ
cord-007689-0vpp3xdl	269	30	a	a	DT
cord-007689-0vpp3xdl	269	31	protein	protein	NN
cord-007689-0vpp3xdl	269	32	known	know	VBN
cord-007689-0vpp3xdl	269	33	as	as	IN
cord-007689-0vpp3xdl	269	34	viral	viral	JJ
cord-007689-0vpp3xdl	269	35	genome	genome	NN
cord-007689-0vpp3xdl	269	36	-	-	HYPH
cord-007689-0vpp3xdl	269	37	linked	link	VBN
cord-007689-0vpp3xdl	269	38	protein	protein	NN
cord-007689-0vpp3xdl	269	39	(	(	-LRB-
cord-007689-0vpp3xdl	269	40	VPg	VPg	NNS
cord-007689-0vpp3xdl	269	41	)	)	-RRB-
cord-007689-0vpp3xdl	269	42	as	as	IN
cord-007689-0vpp3xdl	269	43	a	a	DT
cord-007689-0vpp3xdl	269	44	primer	primer	NN
cord-007689-0vpp3xdl	269	45	for	for	IN
cord-007689-0vpp3xdl	269	46	both	both	DT
cord-007689-0vpp3xdl	269	47	positive	positive	JJ
cord-007689-0vpp3xdl	269	48	-	-	HYPH
cord-007689-0vpp3xdl	269	49	and	and	CC
cord-007689-0vpp3xdl	269	50	negative	negative	JJ
cord-007689-0vpp3xdl	269	51	-	-	HYPH
cord-007689-0vpp3xdl	269	52	strand	strand	NN
cord-007689-0vpp3xdl	269	53	RNA	RNA	NNP
cord-007689-0vpp3xdl	269	54	production	production	NN
cord-007689-0vpp3xdl	269	55	.	.	.
cord-007689-0vpp3xdl	270	1	This	this	DT
cord-007689-0vpp3xdl	270	2	protein	protein	NN
cord-007689-0vpp3xdl	270	3	primer	primer	NN
cord-007689-0vpp3xdl	270	4	is	be	VBZ
cord-007689-0vpp3xdl	270	5	part	part	NN
cord-007689-0vpp3xdl	270	6	of	of	IN
cord-007689-0vpp3xdl	270	7	the	the	DT
cord-007689-0vpp3xdl	270	8	precursor	precursor	NN
cord-007689-0vpp3xdl	270	9	RdRp	RdRp	NNP
cord-007689-0vpp3xdl	270	10	and	and	CC
cord-007689-0vpp3xdl	270	11	is	be	VBZ
cord-007689-0vpp3xdl	270	12	cleaved	cleave	VBN
cord-007689-0vpp3xdl	270	13	off	off	RP
cord-007689-0vpp3xdl	270	14	as	as	IN
cord-007689-0vpp3xdl	270	15	elongation	elongation	NN
cord-007689-0vpp3xdl	270	16	of	of	IN
cord-007689-0vpp3xdl	270	17	the	the	DT
cord-007689-0vpp3xdl	270	18	initial	initial	JJ
cord-007689-0vpp3xdl	270	19	complex	complex	NN
cord-007689-0vpp3xdl	270	20	occurs	occur	VBZ
cord-007689-0vpp3xdl	270	21	,	,	,
cord-007689-0vpp3xdl	270	22	usually	usually	RB
cord-007689-0vpp3xdl	270	23	to	to	TO
cord-007689-0vpp3xdl	270	24	become	become	VB
cord-007689-0vpp3xdl	270	25	a	a	DT
cord-007689-0vpp3xdl	270	26	5′-genome	5′-genome	CD
cord-007689-0vpp3xdl	270	27	-	-	HYPH
cord-007689-0vpp3xdl	270	28	linked	link	VBN
cord-007689-0vpp3xdl	270	29	protein	protein	NN
cord-007689-0vpp3xdl	270	30	(	(	-LRB-
cord-007689-0vpp3xdl	270	31	Lee	Lee	NNP
cord-007689-0vpp3xdl	270	32	et	et	NNP
cord-007689-0vpp3xdl	270	33	al	al	NNP
cord-007689-0vpp3xdl	270	34	.	.	NNP
cord-007689-0vpp3xdl	270	35	1977	1977	CD
cord-007689-0vpp3xdl	270	36	)	)	-RRB-
cord-007689-0vpp3xdl	270	37	.	.	.
cord-007689-0vpp3xdl	271	1	Thus	thus	RB
cord-007689-0vpp3xdl	271	2	during	during	IN
cord-007689-0vpp3xdl	271	3	the	the	DT
cord-007689-0vpp3xdl	271	4	life	life	NN
cord-007689-0vpp3xdl	271	5	-	-	HYPH
cord-007689-0vpp3xdl	271	6	cycle	cycle	NN
cord-007689-0vpp3xdl	271	7	of	of	IN
cord-007689-0vpp3xdl	271	8	Picornaviruses	Picornaviruses	NNP
cord-007689-0vpp3xdl	271	9	uncapped	uncapped	JJ
cord-007689-0vpp3xdl	271	10	,	,	,
cord-007689-0vpp3xdl	271	11	triphosphorylated	triphosphorylated	JJ
cord-007689-0vpp3xdl	271	12	5′	5′	NN
cord-007689-0vpp3xdl	271	13	ends	end	NNS
cord-007689-0vpp3xdl	271	14	are	be	VBP
cord-007689-0vpp3xdl	271	15	absent	absent	JJ
cord-007689-0vpp3xdl	271	16	.	.	.
cord-007689-0vpp3xdl	272	1	Consequently	consequently	RB
cord-007689-0vpp3xdl	272	2	,	,	,
cord-007689-0vpp3xdl	272	3	based	base	VBN
cord-007689-0vpp3xdl	272	4	on	on	IN
cord-007689-0vpp3xdl	272	5	our	-PRON-	PRP$
cord-007689-0vpp3xdl	272	6	studies	study	NNS
cord-007689-0vpp3xdl	272	7	,	,	,
cord-007689-0vpp3xdl	272	8	RIG	rig	NN
cord-007689-0vpp3xdl	272	9	-	-	:
cord-007689-0vpp3xdl	272	10	I	-PRON-	PRP
cord-007689-0vpp3xdl	272	11	is	be	VBZ
cord-007689-0vpp3xdl	272	12	expected	expect	VBN
cord-007689-0vpp3xdl	272	13	to	to	TO
cord-007689-0vpp3xdl	272	14	be	be	VB
cord-007689-0vpp3xdl	272	15	involved	involve	VBN
cord-007689-0vpp3xdl	272	16	in	in	IN
cord-007689-0vpp3xdl	272	17	the	the	DT
cord-007689-0vpp3xdl	272	18	detection	detection	NN
cord-007689-0vpp3xdl	272	19	of	of	IN
cord-007689-0vpp3xdl	272	20	Flaviviridae	Flaviviridae	NNP
cord-007689-0vpp3xdl	272	21	and	and	CC
cord-007689-0vpp3xdl	272	22	NSV	nsv	NN
cord-007689-0vpp3xdl	272	23	but	but	CC
cord-007689-0vpp3xdl	272	24	not	not	RB
cord-007689-0vpp3xdl	272	25	Picornaviruses	Picornaviruses	NNP
cord-007689-0vpp3xdl	272	26	.	.	.
cord-007689-0vpp3xdl	273	1	This	this	DT
cord-007689-0vpp3xdl	273	2	is	be	VBZ
cord-007689-0vpp3xdl	273	3	confirmed	confirm	VBN
cord-007689-0vpp3xdl	273	4	in	in	IN
cord-007689-0vpp3xdl	273	5	a	a	DT
cord-007689-0vpp3xdl	273	6	recent	recent	JJ
cord-007689-0vpp3xdl	273	7	study	study	NN
cord-007689-0vpp3xdl	273	8	.	.	.
cord-007689-0vpp3xdl	274	1	A	a	DT
cord-007689-0vpp3xdl	274	2	number	number	NN
cord-007689-0vpp3xdl	274	3	of	of	IN
cord-007689-0vpp3xdl	274	4	studies	study	NNS
cord-007689-0vpp3xdl	274	5	suggested	suggest	VBD
cord-007689-0vpp3xdl	274	6	that	that	IN
cord-007689-0vpp3xdl	274	7	the	the	DT
cord-007689-0vpp3xdl	274	8	helicases	helicase	NNS
cord-007689-0vpp3xdl	274	9	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	274	10	and	and	CC
cord-007689-0vpp3xdl	274	11	RIG	rig	NN
cord-007689-0vpp3xdl	274	12	-	-	:
cord-007689-0vpp3xdl	274	13	I	-PRON-	PRP
cord-007689-0vpp3xdl	274	14	recognize	recognize	VBP
cord-007689-0vpp3xdl	274	15	dsRNA	dsRNA	.
cord-007689-0vpp3xdl	275	1	(	(	-LRB-
cord-007689-0vpp3xdl	275	2	Andrejeva	Andrejeva	NNP
cord-007689-0vpp3xdl	275	3	et	et	NNP
cord-007689-0vpp3xdl	275	4	al	al	NNP
cord-007689-0vpp3xdl	275	5	.	.	.
cord-007689-0vpp3xdl	276	1	2004	2004	CD
cord-007689-0vpp3xdl	276	2	;	;	:
cord-007689-0vpp3xdl	276	3	Rothenfusser	Rothenfusser	NNP
cord-007689-0vpp3xdl	276	4	et	et	NNP
cord-007689-0vpp3xdl	276	5	al	al	NNP
cord-007689-0vpp3xdl	276	6	.	.	.
cord-007689-0vpp3xdl	277	1	2005	2005	CD
cord-007689-0vpp3xdl	277	2	;	;	:
cord-007689-0vpp3xdl	277	3	Yoneyama	Yoneyama	NNP
cord-007689-0vpp3xdl	277	4	et	et	NNP
cord-007689-0vpp3xdl	277	5	al	al	NNP
cord-007689-0vpp3xdl	277	6	.	.	.
cord-007689-0vpp3xdl	277	7	2004	2004	CD
cord-007689-0vpp3xdl	277	8	)	)	-RRB-
cord-007689-0vpp3xdl	277	9	.	.	.
cord-007689-0vpp3xdl	278	1	The	the	DT
cord-007689-0vpp3xdl	278	2	results	result	NNS
cord-007689-0vpp3xdl	278	3	in	in	IN
cord-007689-0vpp3xdl	278	4	the	the	DT
cord-007689-0vpp3xdl	278	5	work	work	NN
cord-007689-0vpp3xdl	278	6	of	of	IN
cord-007689-0vpp3xdl	278	7	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	278	8	and	and	CC
cord-007689-0vpp3xdl	278	9	colleagues	colleague	NNS
cord-007689-0vpp3xdl	278	10	(	(	-LRB-
cord-007689-0vpp3xdl	278	11	2006	2006	CD
cord-007689-0vpp3xdl	278	12	)	)	-RRB-
cord-007689-0vpp3xdl	278	13	demonstrated	demonstrate	VBD
cord-007689-0vpp3xdl	278	14	that	that	IN
cord-007689-0vpp3xdl	278	15	double	double	JJ
cord-007689-0vpp3xdl	278	16	-	-	HYPH
cord-007689-0vpp3xdl	278	17	strand	strand	NN
cord-007689-0vpp3xdl	278	18	formation	formation	NN
cord-007689-0vpp3xdl	278	19	of	of	IN
cord-007689-0vpp3xdl	278	20	RNA	RNA	NNP
cord-007689-0vpp3xdl	278	21	is	be	VBZ
cord-007689-0vpp3xdl	278	22	not	not	RB
cord-007689-0vpp3xdl	278	23	required	require	VBN
cord-007689-0vpp3xdl	278	24	for	for	IN
cord-007689-0vpp3xdl	278	25	RIG	rig	NN
cord-007689-0vpp3xdl	278	26	-	-	HYPH
cord-007689-0vpp3xdl	278	27	I	I	NNP
cord-007689-0vpp3xdl	278	28	-	-	HYPH
cord-007689-0vpp3xdl	278	29	RNA	RNA	NNP
cord-007689-0vpp3xdl	278	30	interaction	interaction	NN
cord-007689-0vpp3xdl	278	31	,	,	,
cord-007689-0vpp3xdl	278	32	and	and	CC
cord-007689-0vpp3xdl	278	33	that	that	IN
cord-007689-0vpp3xdl	278	34	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	278	35	is	be	VBZ
cord-007689-0vpp3xdl	278	36	not	not	RB
cord-007689-0vpp3xdl	278	37	sufficient	sufficient	JJ
cord-007689-0vpp3xdl	278	38	for	for	IN
cord-007689-0vpp3xdl	278	39	RIG	rig	NN
cord-007689-0vpp3xdl	278	40	-	-	:
cord-007689-0vpp3xdl	278	41	I	-PRON-	PRP
cord-007689-0vpp3xdl	278	42	activation	activation	NN
cord-007689-0vpp3xdl	278	43	.	.	.
cord-007689-0vpp3xdl	279	1	These	these	DT
cord-007689-0vpp3xdl	279	2	results	result	NNS
cord-007689-0vpp3xdl	279	3	further	further	RB
cord-007689-0vpp3xdl	279	4	demonstrate	demonstrate	VBP
cord-007689-0vpp3xdl	279	5	that	that	IN
cord-007689-0vpp3xdl	279	6	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	279	7	is	be	VBZ
cord-007689-0vpp3xdl	279	8	not	not	RB
cord-007689-0vpp3xdl	279	9	involved	involve	VBN
cord-007689-0vpp3xdl	279	10	in	in	IN
cord-007689-0vpp3xdl	279	11	5′-triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	279	12	RNA	RNA	NNP
cord-007689-0vpp3xdl	279	13	recognition	recognition	NN
cord-007689-0vpp3xdl	279	14	.	.	.
cord-007689-0vpp3xdl	280	1	Although	although	IN
cord-007689-0vpp3xdl	280	2	there	there	EX
cord-007689-0vpp3xdl	280	3	is	be	VBZ
cord-007689-0vpp3xdl	280	4	convincing	convincing	JJ
cord-007689-0vpp3xdl	280	5	evidence	evidence	NN
cord-007689-0vpp3xdl	280	6	that	that	IN
cord-007689-0vpp3xdl	280	7	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	280	8	is	be	VBZ
cord-007689-0vpp3xdl	280	9	activated	activate	VBN
cord-007689-0vpp3xdl	280	10	by	by	IN
cord-007689-0vpp3xdl	280	11	the	the	DT
cord-007689-0vpp3xdl	280	12	long	long	JJ
cord-007689-0vpp3xdl	280	13	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	280	14	mimic	mimic	VBP
cord-007689-0vpp3xdl	280	15	poly	poly	NNP
cord-007689-0vpp3xdl	280	16	I	i	NN
cord-007689-0vpp3xdl	280	17	:	:	:
cord-007689-0vpp3xdl	280	18	C	C	NNP
cord-007689-0vpp3xdl	280	19	,	,	,
cord-007689-0vpp3xdl	280	20	activation	activation	NN
cord-007689-0vpp3xdl	280	21	of	of	IN
cord-007689-0vpp3xdl	280	22	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	280	23	by	by	IN
cord-007689-0vpp3xdl	280	24	natural	natural	JJ
cord-007689-0vpp3xdl	280	25	long	long	JJ
cord-007689-0vpp3xdl	280	26	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	280	27	is	be	VBZ
cord-007689-0vpp3xdl	280	28	still	still	RB
cord-007689-0vpp3xdl	280	29	controversial	controversial	JJ
cord-007689-0vpp3xdl	280	30	.	.	.
cord-007689-0vpp3xdl	281	1	Taken	take	VBN
cord-007689-0vpp3xdl	281	2	together	together	RB
cord-007689-0vpp3xdl	281	3	,	,	,
cord-007689-0vpp3xdl	281	4	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	281	5	is	be	VBZ
cord-007689-0vpp3xdl	281	6	so	so	RB
cord-007689-0vpp3xdl	281	7	far	far	RB
cord-007689-0vpp3xdl	281	8	the	the	DT
cord-007689-0vpp3xdl	281	9	only	only	JJ
cord-007689-0vpp3xdl	281	10	receptor	receptor	NN
cord-007689-0vpp3xdl	281	11	that	that	WDT
cord-007689-0vpp3xdl	281	12	induces	induce	VBZ
cord-007689-0vpp3xdl	281	13	type	type	NN
cord-007689-0vpp3xdl	281	14	I	-PRON-	PRP
cord-007689-0vpp3xdl	281	15	IFN	IFN	NNP
cord-007689-0vpp3xdl	281	16	upon	upon	IN
cord-007689-0vpp3xdl	281	17	binding	bind	VBG
cord-007689-0vpp3xdl	281	18	of	of	IN
cord-007689-0vpp3xdl	281	19	the	the	DT
cord-007689-0vpp3xdl	281	20	natural	natural	JJ
cord-007689-0vpp3xdl	281	21	molecule	molecule	NN
cord-007689-0vpp3xdl	281	22	long	long	JJ
cord-007689-0vpp3xdl	281	23	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	281	24	,	,	,
cord-007689-0vpp3xdl	281	25	but	but	CC
cord-007689-0vpp3xdl	281	26	the	the	DT
cord-007689-0vpp3xdl	281	27	contribution	contribution	NN
cord-007689-0vpp3xdl	281	28	of	of	IN
cord-007689-0vpp3xdl	281	29	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	281	30	to	to	TO
cord-007689-0vpp3xdl	281	31	type	type	VB
cord-007689-0vpp3xdl	281	32	I	-PRON-	PRP
cord-007689-0vpp3xdl	281	33	IFN	IFN	NNP
cord-007689-0vpp3xdl	281	34	induction	induction	NN
cord-007689-0vpp3xdl	281	35	and	and	CC
cord-007689-0vpp3xdl	281	36	viral	viral	JJ
cord-007689-0vpp3xdl	281	37	clearance	clearance	NN
cord-007689-0vpp3xdl	281	38	in	in	IN
cord-007689-0vpp3xdl	281	39	vivo	vivo	NNP
cord-007689-0vpp3xdl	281	40	seems	seem	VBZ
cord-007689-0vpp3xdl	281	41	to	to	TO
cord-007689-0vpp3xdl	281	42	be	be	VB
cord-007689-0vpp3xdl	281	43	weak	weak	JJ
cord-007689-0vpp3xdl	282	1	(	(	-LRB-
cord-007689-0vpp3xdl	282	2	Rudd	Rudd	NNP
cord-007689-0vpp3xdl	282	3	et	et	NNP
cord-007689-0vpp3xdl	282	4	al	al	NNP
cord-007689-0vpp3xdl	282	5	.	.	.
cord-007689-0vpp3xdl	282	6	2006	2006	CD
cord-007689-0vpp3xdl	282	7	)	)	-RRB-
cord-007689-0vpp3xdl	282	8	.	.	.
cord-007689-0vpp3xdl	283	1	There	there	EX
cord-007689-0vpp3xdl	283	2	is	be	VBZ
cord-007689-0vpp3xdl	283	3	good	good	JJ
cord-007689-0vpp3xdl	283	4	evidence	evidence	NN
cord-007689-0vpp3xdl	283	5	that	that	IN
cord-007689-0vpp3xdl	283	6	short	short	JJ
cord-007689-0vpp3xdl	283	7	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	283	8	such	such	JJ
cord-007689-0vpp3xdl	283	9	as	as	IN
cord-007689-0vpp3xdl	283	10	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	283	11	generated	generate	VBN
cord-007689-0vpp3xdl	283	12	by	by	IN
cord-007689-0vpp3xdl	283	13	Dicermediated	Dicermediated	NNP
cord-007689-0vpp3xdl	283	14	cleavage	cleavage	NN
cord-007689-0vpp3xdl	283	15	of	of	IN
cord-007689-0vpp3xdl	283	16	long	long	JJ
cord-007689-0vpp3xdl	283	17	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	283	18	does	do	VBZ
cord-007689-0vpp3xdl	283	19	not	not	RB
cord-007689-0vpp3xdl	283	20	elicit	elicit	VB
cord-007689-0vpp3xdl	283	21	a	a	DT
cord-007689-0vpp3xdl	283	22	type	type	NN
cord-007689-0vpp3xdl	283	23	I	-PRON-	PRP
cord-007689-0vpp3xdl	283	24	IFN	IFN	NNP
cord-007689-0vpp3xdl	283	25	response	response	NN
cord-007689-0vpp3xdl	283	26	in	in	IN
cord-007689-0vpp3xdl	283	27	nonimmune	nonimmune	NNP
cord-007689-0vpp3xdl	283	28	cells	cell	NNS
cord-007689-0vpp3xdl	284	1	(	(	-LRB-
cord-007689-0vpp3xdl	284	2	Elbashir	Elbashir	NNP
cord-007689-0vpp3xdl	284	3	et	et	FW
cord-007689-0vpp3xdl	284	4	al	al	NNP
cord-007689-0vpp3xdl	284	5	.	.	.
cord-007689-0vpp3xdl	285	1	2001	2001	CD
cord-007689-0vpp3xdl	285	2	;	;	:
cord-007689-0vpp3xdl	285	3	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	285	4	et	et	NNP
cord-007689-0vpp3xdl	285	5	al	al	NNP
cord-007689-0vpp3xdl	285	6	.	.	.
cord-007689-0vpp3xdl	286	1	2005	2005	CD
cord-007689-0vpp3xdl	286	2	;	;	:
cord-007689-0vpp3xdl	286	3	Kim	Kim	NNP
cord-007689-0vpp3xdl	286	4	et	et	NNP
cord-007689-0vpp3xdl	286	5	al	al	NNP
cord-007689-0vpp3xdl	286	6	.	.	.
cord-007689-0vpp3xdl	286	7	2004	2004	CD
cord-007689-0vpp3xdl	286	8	)	)	-RRB-
cord-007689-0vpp3xdl	286	9	.	.	.
cord-007689-0vpp3xdl	287	1	A	a	DT
cord-007689-0vpp3xdl	287	2	recent	recent	JJ
cord-007689-0vpp3xdl	287	3	study	study	NN
cord-007689-0vpp3xdl	287	4	suggests	suggest	VBZ
cord-007689-0vpp3xdl	287	5	that	that	IN
cord-007689-0vpp3xdl	287	6	the	the	DT
cord-007689-0vpp3xdl	287	7	two	two	CD
cord-007689-0vpp3xdl	287	8	-	-	HYPH
cord-007689-0vpp3xdl	287	9	nucleotide	nucleotide	JJ
cord-007689-0vpp3xdl	287	10	overhang	overhang	NN
cord-007689-0vpp3xdl	287	11	at	at	IN
cord-007689-0vpp3xdl	287	12	the	the	DT
cord-007689-0vpp3xdl	287	13	3′	3′	CD
cord-007689-0vpp3xdl	287	14	end	end	NN
cord-007689-0vpp3xdl	287	15	of	of	IN
cord-007689-0vpp3xdl	287	16	dicer	dicer	NN
cord-007689-0vpp3xdl	287	17	cleavage	cleavage	NN
cord-007689-0vpp3xdl	287	18	products	product	NNS
cord-007689-0vpp3xdl	287	19	are	be	VBP
cord-007689-0vpp3xdl	287	20	essential	essential	JJ
cord-007689-0vpp3xdl	287	21	for	for	IN
cord-007689-0vpp3xdl	287	22	the	the	DT
cord-007689-0vpp3xdl	287	23	lack	lack	NN
cord-007689-0vpp3xdl	287	24	of	of	IN
cord-007689-0vpp3xdl	287	25	immunorecognition	immunorecognition	NN
cord-007689-0vpp3xdl	287	26	of	of	IN
cord-007689-0vpp3xdl	287	27	short	short	NNP
cord-007689-0vpp3xdl	287	28	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	288	1	(	(	-LRB-
cord-007689-0vpp3xdl	288	2	Marques	Marques	NNP
cord-007689-0vpp3xdl	288	3	et	et	NNP
cord-007689-0vpp3xdl	288	4	al	al	NNP
cord-007689-0vpp3xdl	288	5	.	.	.
cord-007689-0vpp3xdl	288	6	2006	2006	CD
cord-007689-0vpp3xdl	288	7	)	)	-RRB-
cord-007689-0vpp3xdl	288	8	.	.	.
cord-007689-0vpp3xdl	289	1	The	the	DT
cord-007689-0vpp3xdl	289	2	same	same	JJ
cord-007689-0vpp3xdl	289	3	study	study	NN
cord-007689-0vpp3xdl	289	4	proposed	propose	VBD
cord-007689-0vpp3xdl	289	5	that	that	IN
cord-007689-0vpp3xdl	289	6	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	289	7	blunt	blunt	JJ
cord-007689-0vpp3xdl	289	8	-	-	HYPH
cord-007689-0vpp3xdl	289	9	end	end	NN
cord-007689-0vpp3xdl	289	10	short	short	JJ
cord-007689-0vpp3xdl	289	11	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	289	12	is	be	VBZ
cord-007689-0vpp3xdl	289	13	recognized	recognize	VBN
cord-007689-0vpp3xdl	289	14	via	via	IN
cord-007689-0vpp3xdl	289	15	RIG	rig	NN
cord-007689-0vpp3xdl	289	16	-	-	HYPH
cord-007689-0vpp3xdl	289	17	I.	i.	NN
cord-007689-0vpp3xdl	290	1	The	the	DT
cord-007689-0vpp3xdl	290	2	conclusion	conclusion	NN
cord-007689-0vpp3xdl	290	3	that	that	IN
cord-007689-0vpp3xdl	290	4	RIG	rig	NN
cord-007689-0vpp3xdl	290	5	-	-	:
cord-007689-0vpp3xdl	290	6	I	-PRON-	PRP
cord-007689-0vpp3xdl	290	7	is	be	VBZ
cord-007689-0vpp3xdl	290	8	the	the	DT
cord-007689-0vpp3xdl	290	9	receptor	receptor	NN
cord-007689-0vpp3xdl	290	10	for	for	IN
cord-007689-0vpp3xdl	290	11	blunt	blunt	JJ
cord-007689-0vpp3xdl	290	12	end	end	NN
cord-007689-0vpp3xdl	290	13	short	short	JJ
cord-007689-0vpp3xdl	290	14	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	290	15	is	be	VBZ
cord-007689-0vpp3xdl	290	16	based	base	VBN
cord-007689-0vpp3xdl	290	17	on	on	IN
cord-007689-0vpp3xdl	290	18	experiments	experiment	NNS
cord-007689-0vpp3xdl	290	19	using	use	VBG
cord-007689-0vpp3xdl	290	20	RIG-	RIG-	NNP
cord-007689-0vpp3xdl	291	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	291	2	overexpression	overexpression	VBP
cord-007689-0vpp3xdl	291	3	and	and	CC
cord-007689-0vpp3xdl	291	4	using	use	VBG
cord-007689-0vpp3xdl	291	5	anti	anti	JJ
cord-007689-0vpp3xdl	291	6	-	-	JJ
cord-007689-0vpp3xdl	291	7	RIG	rig	NN
cord-007689-0vpp3xdl	291	8	-	-	HYPH
cord-007689-0vpp3xdl	291	9	I	I	NNP
cord-007689-0vpp3xdl	291	10	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	291	11	(	(	-LRB-
cord-007689-0vpp3xdl	291	12	short	short	NNP
cord-007689-0vpp3xdl	291	13	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	291	14	with	with	IN
cord-007689-0vpp3xdl	291	15	two	two	CD
cord-007689-0vpp3xdl	291	16	-	-	HYPH
cord-007689-0vpp3xdl	291	17	nucleotide	nucleotide	NN
cord-007689-0vpp3xdl	291	18	3′overhangs	3′overhangs	CD
cord-007689-0vpp3xdl	291	19	)	)	-RRB-
cord-007689-0vpp3xdl	291	20	on	on	IN
cord-007689-0vpp3xdl	291	21	top	top	NN
cord-007689-0vpp3xdl	291	22	of	of	IN
cord-007689-0vpp3xdl	291	23	stimulation	stimulation	NN
cord-007689-0vpp3xdl	291	24	with	with	IN
cord-007689-0vpp3xdl	291	25	blunt	blunt	JJ
cord-007689-0vpp3xdl	291	26	end	end	NN
cord-007689-0vpp3xdl	291	27	short	short	JJ
cord-007689-0vpp3xdl	291	28	dsRNA	dsrna	JJ
cord-007689-0vpp3xdl	291	29	stimulation	stimulation	NN
cord-007689-0vpp3xdl	291	30	.	.	.
cord-007689-0vpp3xdl	292	1	RIG	rig	NN
cord-007689-0vpp3xdl	292	2	-	-	HYPH
cord-007689-0vpp3xdl	292	3	I	i	NN
cord-007689-0vpp3xdl	292	4	-	-	HYPH
cord-007689-0vpp3xdl	292	5	deficient	deficient	JJ
cord-007689-0vpp3xdl	292	6	cells	cell	NNS
cord-007689-0vpp3xdl	292	7	have	have	VBP
cord-007689-0vpp3xdl	292	8	not	not	RB
cord-007689-0vpp3xdl	292	9	been	be	VBN
cord-007689-0vpp3xdl	292	10	examined	examine	VBN
cord-007689-0vpp3xdl	292	11	in	in	IN
cord-007689-0vpp3xdl	292	12	this	this	DT
cord-007689-0vpp3xdl	292	13	study	study	NN
cord-007689-0vpp3xdl	292	14	.	.	.
cord-007689-0vpp3xdl	293	1	This	this	DT
cord-007689-0vpp3xdl	293	2	experimental	experimental	JJ
cord-007689-0vpp3xdl	293	3	design	design	NN
cord-007689-0vpp3xdl	293	4	does	do	VBZ
cord-007689-0vpp3xdl	293	5	not	not	RB
cord-007689-0vpp3xdl	293	6	provide	provide	VB
cord-007689-0vpp3xdl	293	7	clear	clear	RB
cord-007689-0vpp3xdl	293	8	-	-	HYPH
cord-007689-0vpp3xdl	293	9	cut	cut	VBN
cord-007689-0vpp3xdl	293	10	evidence	evidence	NN
cord-007689-0vpp3xdl	293	11	for	for	IN
cord-007689-0vpp3xdl	293	12	the	the	DT
cord-007689-0vpp3xdl	293	13	primary	primary	JJ
cord-007689-0vpp3xdl	293	14	involvement	involvement	NN
cord-007689-0vpp3xdl	293	15	of	of	IN
cord-007689-0vpp3xdl	293	16	RIG	rig	NN
cord-007689-0vpp3xdl	293	17	-	-	:
cord-007689-0vpp3xdl	293	18	I	-PRON-	PRP
cord-007689-0vpp3xdl	293	19	in	in	IN
cord-007689-0vpp3xdl	293	20	type	type	NN
cord-007689-0vpp3xdl	294	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	294	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	294	3	induction	induction	NN
cord-007689-0vpp3xdl	294	4	by	by	IN
cord-007689-0vpp3xdl	294	5	blunt	blunt	JJ
cord-007689-0vpp3xdl	294	6	-	-	HYPH
cord-007689-0vpp3xdl	294	7	end	end	NN
cord-007689-0vpp3xdl	294	8	short	short	JJ
cord-007689-0vpp3xdl	294	9	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	294	10	.	.	.
cord-007689-0vpp3xdl	295	1	Furthermore	furthermore	RB
cord-007689-0vpp3xdl	295	2	,	,	,
cord-007689-0vpp3xdl	295	3	in	in	IN
cord-007689-0vpp3xdl	295	4	the	the	DT
cord-007689-0vpp3xdl	295	5	study	study	NN
cord-007689-0vpp3xdl	295	6	by	by	IN
cord-007689-0vpp3xdl	295	7	Hornung	Hornung	NNP
cord-007689-0vpp3xdl	295	8	and	and	CC
cord-007689-0vpp3xdl	295	9	colleagues	colleague	NNS
cord-007689-0vpp3xdl	295	10	,	,	,
cord-007689-0vpp3xdl	295	11	5′	5′	CD
cord-007689-0vpp3xdl	295	12	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	295	13	blunt	blunt	JJ
cord-007689-0vpp3xdl	295	14	-	-	HYPH
cord-007689-0vpp3xdl	295	15	end	end	NN
cord-007689-0vpp3xdl	295	16	RNA	rna	NN
cord-007689-0vpp3xdl	295	17	and	and	CC
cord-007689-0vpp3xdl	295	18	5′	5′	CD
cord-007689-0vpp3xdl	295	19	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	295	20	2-nt	2-nt	CD
cord-007689-0vpp3xdl	295	21	overhang	overhang	NN
cord-007689-0vpp3xdl	296	1	RNA	RNA	NNP
cord-007689-0vpp3xdl	296	2	showed	show	VBD
cord-007689-0vpp3xdl	296	3	identical	identical	JJ
cord-007689-0vpp3xdl	296	4	RIG	rig	NN
cord-007689-0vpp3xdl	296	5	-	-	HYPH
cord-007689-0vpp3xdl	296	6	I	i	NN
cord-007689-0vpp3xdl	296	7	ligand	ligand	NN
cord-007689-0vpp3xdl	296	8	activity	activity	NN
cord-007689-0vpp3xdl	296	9	,	,	,
cord-007689-0vpp3xdl	296	10	suggesting	suggest	VBG
cord-007689-0vpp3xdl	296	11	that	that	IN
cord-007689-0vpp3xdl	296	12	the	the	DT
cord-007689-0vpp3xdl	296	13	molecular	molecular	JJ
cord-007689-0vpp3xdl	296	14	feature	feature	NN
cord-007689-0vpp3xdl	296	15	2-nt	2-nt	CD
cord-007689-0vpp3xdl	296	16	overhang	overhang	NN
cord-007689-0vpp3xdl	296	17	does	do	VBZ
cord-007689-0vpp3xdl	296	18	not	not	RB
cord-007689-0vpp3xdl	296	19	inhibit	inhibit	VB
cord-007689-0vpp3xdl	296	20	RIG	rig	NN
cord-007689-0vpp3xdl	296	21	-	-	HYPH
cord-007689-0vpp3xdl	296	22	I	i	NN
cord-007689-0vpp3xdl	296	23	-	-	HYPH
cord-007689-0vpp3xdl	296	24	mediated	mediate	VBN
cord-007689-0vpp3xdl	296	25	recognition	recognition	NN
cord-007689-0vpp3xdl	296	26	)	)	-RRB-
cord-007689-0vpp3xdl	296	27	.	.	.
cord-007689-0vpp3xdl	297	1	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	297	2	is	be	VBZ
cord-007689-0vpp3xdl	297	3	structurally	structurally	RB
cord-007689-0vpp3xdl	297	4	related	relate	VBN
cord-007689-0vpp3xdl	297	5	to	to	IN
cord-007689-0vpp3xdl	297	6	RIG	rig	NN
cord-007689-0vpp3xdl	297	7	-	-	:
cord-007689-0vpp3xdl	297	8	I	-PRON-	PRP
cord-007689-0vpp3xdl	297	9	,	,	,
cord-007689-0vpp3xdl	297	10	as	as	IN
cord-007689-0vpp3xdl	297	11	it	-PRON-	PRP
cord-007689-0vpp3xdl	297	12	also	also	RB
cord-007689-0vpp3xdl	297	13	contains	contain	VBZ
cord-007689-0vpp3xdl	297	14	two	two	CD
cord-007689-0vpp3xdl	297	15	CARD	card	NN
cord-007689-0vpp3xdl	297	16	domains	domain	NNS
cord-007689-0vpp3xdl	297	17	and	and	CC
cord-007689-0vpp3xdl	297	18	a	a	DT
cord-007689-0vpp3xdl	297	19	helicase	helicase	NN
cord-007689-0vpp3xdl	297	20	domain	domain	NN
cord-007689-0vpp3xdl	297	21	.	.	.
cord-007689-0vpp3xdl	298	1	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	298	2	was	be	VBD
cord-007689-0vpp3xdl	298	3	originally	originally	RB
cord-007689-0vpp3xdl	298	4	identified	identify	VBN
cord-007689-0vpp3xdl	298	5	as	as	IN
cord-007689-0vpp3xdl	298	6	a	a	DT
cord-007689-0vpp3xdl	298	7	type	type	NN
cord-007689-0vpp3xdl	298	8	I	-PRON-	PRP
cord-007689-0vpp3xdl	298	9	IFN	IFN	NNP
cord-007689-0vpp3xdl	298	10	-	-	HYPH
cord-007689-0vpp3xdl	298	11	inducible	inducible	JJ
cord-007689-0vpp3xdl	298	12	molecule	molecule	NN
cord-007689-0vpp3xdl	298	13	mediating	mediate	VBG
cord-007689-0vpp3xdl	298	14	cell	cell	NN
cord-007689-0vpp3xdl	298	15	cycle	cycle	NN
cord-007689-0vpp3xdl	298	16	arrest	arrest	NN
cord-007689-0vpp3xdl	298	17	and	and	CC
cord-007689-0vpp3xdl	298	18	apoptosis	apoptosis	NN
cord-007689-0vpp3xdl	298	19	in	in	IN
cord-007689-0vpp3xdl	298	20	melanoma	melanoma	NN
cord-007689-0vpp3xdl	298	21	cells	cell	NNS
cord-007689-0vpp3xdl	298	22	(	(	-LRB-
cord-007689-0vpp3xdl	299	1	hence	hence	RB
cord-007689-0vpp3xdl	299	2	the	the	DT
cord-007689-0vpp3xdl	299	3	name	name	NN
cord-007689-0vpp3xdl	299	4	melanoma	melanoma	NN
cord-007689-0vpp3xdl	299	5	differentiation	differentiation	NN
cord-007689-0vpp3xdl	299	6	antigen	antigen	NNP
cord-007689-0vpp3xdl	299	7	5	5	CD
cord-007689-0vpp3xdl	299	8	)	)	-RRB-
cord-007689-0vpp3xdl	300	1	(	(	-LRB-
cord-007689-0vpp3xdl	300	2	Kang	Kang	NNP
cord-007689-0vpp3xdl	300	3	et	et	NNP
cord-007689-0vpp3xdl	300	4	al	al	NNP
cord-007689-0vpp3xdl	300	5	.	.	.
cord-007689-0vpp3xdl	301	1	2002	2002	CD
cord-007689-0vpp3xdl	302	1	(	(	-LRB-
cord-007689-0vpp3xdl	302	2	Kang	Kang	NNP
cord-007689-0vpp3xdl	302	3	et	et	NNP
cord-007689-0vpp3xdl	302	4	al	al	NNP
cord-007689-0vpp3xdl	302	5	.	.	NNP
cord-007689-0vpp3xdl	302	6	,	,	,
cord-007689-0vpp3xdl	303	1	2004	2004	CD
cord-007689-0vpp3xdl	303	2	Kovacsovics	Kovacsovics	NNPS
cord-007689-0vpp3xdl	303	3	et	et	NNP
cord-007689-0vpp3xdl	303	4	al	al	NNP
cord-007689-0vpp3xdl	303	5	.	.	.
cord-007689-0vpp3xdl	303	6	2002	2002	CD
cord-007689-0vpp3xdl	303	7	)	)	-RRB-
cord-007689-0vpp3xdl	303	8	.	.	.
cord-007689-0vpp3xdl	304	1	A	a	DT
cord-007689-0vpp3xdl	304	2	first	first	JJ
cord-007689-0vpp3xdl	304	3	indication	indication	NN
cord-007689-0vpp3xdl	304	4	of	of	IN
cord-007689-0vpp3xdl	304	5	a	a	DT
cord-007689-0vpp3xdl	304	6	role	role	NN
cord-007689-0vpp3xdl	304	7	for	for	IN
cord-007689-0vpp3xdl	304	8	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	304	9	in	in	IN
cord-007689-0vpp3xdl	304	10	virus	virus	NN
cord-007689-0vpp3xdl	304	11	recognition	recognition	NN
cord-007689-0vpp3xdl	304	12	came	come	VBD
cord-007689-0vpp3xdl	304	13	from	from	IN
cord-007689-0vpp3xdl	304	14	the	the	DT
cord-007689-0vpp3xdl	304	15	observation	observation	NN
cord-007689-0vpp3xdl	304	16	that	that	IN
cord-007689-0vpp3xdl	304	17	a	a	DT
cord-007689-0vpp3xdl	304	18	paramyxoviral	paramyxoviral	JJ
cord-007689-0vpp3xdl	304	19	protein	protein	NN
cord-007689-0vpp3xdl	304	20	that	that	WDT
cord-007689-0vpp3xdl	304	21	mediated	mediate	VBD
cord-007689-0vpp3xdl	304	22	immune	immune	JJ
cord-007689-0vpp3xdl	304	23	evasion	evasion	NN
cord-007689-0vpp3xdl	304	24	bound	bind	VBN
cord-007689-0vpp3xdl	304	25	to	to	IN
cord-007689-0vpp3xdl	304	26	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	305	1	(	(	-LRB-
cord-007689-0vpp3xdl	305	2	Andrejeva	Andrejeva	NNP
cord-007689-0vpp3xdl	305	3	et	et	NNP
cord-007689-0vpp3xdl	305	4	al	al	NNP
cord-007689-0vpp3xdl	305	5	.	.	.
cord-007689-0vpp3xdl	305	6	2004	2004	CD
cord-007689-0vpp3xdl	305	7	)	)	-RRB-
cord-007689-0vpp3xdl	305	8	.	.	.
cord-007689-0vpp3xdl	306	1	In	in	IN
cord-007689-0vpp3xdl	306	2	overexpression	overexpression	NN
cord-007689-0vpp3xdl	306	3	experiments	experiment	NNS
cord-007689-0vpp3xdl	306	4	,	,	,
cord-007689-0vpp3xdl	306	5	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	306	6	was	be	VBD
cord-007689-0vpp3xdl	306	7	shown	show	VBN
cord-007689-0vpp3xdl	306	8	to	to	TO
cord-007689-0vpp3xdl	306	9	bind	bind	VB
cord-007689-0vpp3xdl	306	10	poly	poly	NNP
cord-007689-0vpp3xdl	307	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	307	2	:	:	:
cord-007689-0vpp3xdl	307	3	C	C	NNP
cord-007689-0vpp3xdl	307	4	,	,	,
cord-007689-0vpp3xdl	307	5	and	and	CC
cord-007689-0vpp3xdl	307	6	enhanced	enhance	VBD
cord-007689-0vpp3xdl	307	7	the	the	DT
cord-007689-0vpp3xdl	307	8	interferon	interferon	NN
cord-007689-0vpp3xdl	307	9	response	response	NN
cord-007689-0vpp3xdl	307	10	to	to	IN
cord-007689-0vpp3xdl	307	11	poly	poly	NNP
cord-007689-0vpp3xdl	307	12	I	I	NNP
cord-007689-0vpp3xdl	307	13	:	:	:
cord-007689-0vpp3xdl	307	14	C	C	NNP
cord-007689-0vpp3xdl	307	15	as	as	RB
cord-007689-0vpp3xdl	307	16	well	well	RB
cord-007689-0vpp3xdl	307	17	as	as	IN
cord-007689-0vpp3xdl	307	18	several	several	JJ
cord-007689-0vpp3xdl	307	19	viruses	virus	NNS
cord-007689-0vpp3xdl	307	20	.	.	.
cord-007689-0vpp3xdl	308	1	Conversely	conversely	RB
cord-007689-0vpp3xdl	308	2	,	,	,
cord-007689-0vpp3xdl	308	3	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	308	4	mediated	mediate	VBD
cord-007689-0vpp3xdl	308	5	knock	knock	NN
cord-007689-0vpp3xdl	308	6	-	-	HYPH
cord-007689-0vpp3xdl	308	7	down	down	RP
cord-007689-0vpp3xdl	308	8	blocked	block	VBN
cord-007689-0vpp3xdl	308	9	type	type	NN
cord-007689-0vpp3xdl	309	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	309	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	309	3	induction	induction	NN
cord-007689-0vpp3xdl	309	4	in	in	IN
cord-007689-0vpp3xdl	309	5	response	response	NN
cord-007689-0vpp3xdl	309	6	to	to	IN
cord-007689-0vpp3xdl	309	7	these	these	DT
cord-007689-0vpp3xdl	309	8	stimuli	stimulus	NNS
cord-007689-0vpp3xdl	309	9	.	.	.
cord-007689-0vpp3xdl	310	1	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	310	2	was	be	VBD
cord-007689-0vpp3xdl	310	3	then	then	RB
cord-007689-0vpp3xdl	310	4	shown	show	VBN
cord-007689-0vpp3xdl	310	5	to	to	TO
cord-007689-0vpp3xdl	310	6	play	play	VB
cord-007689-0vpp3xdl	310	7	an	an	DT
cord-007689-0vpp3xdl	310	8	essential	essential	JJ
cord-007689-0vpp3xdl	310	9	role	role	NN
cord-007689-0vpp3xdl	310	10	in	in	IN
cord-007689-0vpp3xdl	310	11	the	the	DT
cord-007689-0vpp3xdl	310	12	detection	detection	NN
cord-007689-0vpp3xdl	310	13	of	of	IN
cord-007689-0vpp3xdl	310	14	Picornaviruses	Picornaviruses	NNP
cord-007689-0vpp3xdl	310	15	such	such	JJ
cord-007689-0vpp3xdl	310	16	as	as	IN
cord-007689-0vpp3xdl	310	17	encephalomyocarditis	encephalomyocarditis	NNP
cord-007689-0vpp3xdl	310	18	virus	virus	NN
cord-007689-0vpp3xdl	310	19	(	(	-LRB-
cord-007689-0vpp3xdl	310	20	EMCV	EMCV	NNP
cord-007689-0vpp3xdl	310	21	)	)	-RRB-
cord-007689-0vpp3xdl	310	22	or	or	CC
cord-007689-0vpp3xdl	310	23	Theiler	Theiler	NNP
cord-007689-0vpp3xdl	310	24	's	's	POS
cord-007689-0vpp3xdl	310	25	virus	virus	NN
cord-007689-0vpp3xdl	310	26	(	(	-LRB-
cord-007689-0vpp3xdl	310	27	Gitlin	Gitlin	NNP
cord-007689-0vpp3xdl	310	28	et	et	FW
cord-007689-0vpp3xdl	310	29	al	al	NNP
cord-007689-0vpp3xdl	310	30	.	.	.
cord-007689-0vpp3xdl	311	1	2006	2006	CD
cord-007689-0vpp3xdl	311	2	;	;	:
cord-007689-0vpp3xdl	311	3	Kato	Kato	NNP
cord-007689-0vpp3xdl	311	4	et	et	NNP
cord-007689-0vpp3xdl	311	5	al	al	NNP
cord-007689-0vpp3xdl	311	6	.	.	.
cord-007689-0vpp3xdl	311	7	2006	2006	CD
cord-007689-0vpp3xdl	311	8	)	)	-RRB-
cord-007689-0vpp3xdl	311	9	.	.	.
cord-007689-0vpp3xdl	312	1	In	in	IN
cord-007689-0vpp3xdl	312	2	addition	addition	NN
cord-007689-0vpp3xdl	312	3	,	,	,
cord-007689-0vpp3xdl	312	4	mice	mouse	NNS
cord-007689-0vpp3xdl	312	5	deficient	deficient	JJ
cord-007689-0vpp3xdl	312	6	in	in	IN
cord-007689-0vpp3xdl	312	7	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	312	8	were	be	VBD
cord-007689-0vpp3xdl	312	9	found	find	VBN
cord-007689-0vpp3xdl	312	10	to	to	TO
cord-007689-0vpp3xdl	312	11	be	be	VB
cord-007689-0vpp3xdl	312	12	highly	highly	RB
cord-007689-0vpp3xdl	312	13	susceptible	susceptible	JJ
cord-007689-0vpp3xdl	312	14	to	to	IN
cord-007689-0vpp3xdl	312	15	EMCV	EMCV	NNP
cord-007689-0vpp3xdl	312	16	.	.	.
cord-007689-0vpp3xdl	313	1	Although	although	IN
cord-007689-0vpp3xdl	313	2	the	the	DT
cord-007689-0vpp3xdl	313	3	nature	nature	NN
cord-007689-0vpp3xdl	313	4	of	of	IN
cord-007689-0vpp3xdl	313	5	the	the	DT
cord-007689-0vpp3xdl	313	6	natural	natural	JJ
cord-007689-0vpp3xdl	313	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	313	8	ligand	ligand	NN
cord-007689-0vpp3xdl	313	9	that	that	WDT
cord-007689-0vpp3xdl	313	10	engages	engage	VBZ
cord-007689-0vpp3xdl	313	11	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	313	12	has	have	VBZ
cord-007689-0vpp3xdl	313	13	so	so	RB
cord-007689-0vpp3xdl	313	14	far	far	RB
cord-007689-0vpp3xdl	313	15	remained	remain	VBN
cord-007689-0vpp3xdl	313	16	obscure	obscure	JJ
cord-007689-0vpp3xdl	313	17	,	,	,
cord-007689-0vpp3xdl	313	18	a	a	DT
cord-007689-0vpp3xdl	313	19	surprising	surprising	JJ
cord-007689-0vpp3xdl	313	20	observation	observation	NN
cord-007689-0vpp3xdl	313	21	was	be	VBD
cord-007689-0vpp3xdl	313	22	that	that	IN
cord-007689-0vpp3xdl	313	23	cells	cell	NNS
cord-007689-0vpp3xdl	313	24	derived	derive	VBN
cord-007689-0vpp3xdl	313	25	from	from	IN
cord-007689-0vpp3xdl	313	26	MDA-5-deficient	MDA-5-deficient	NNP
cord-007689-0vpp3xdl	313	27	mice	mice	NNP
cord-007689-0vpp3xdl	313	28	,	,	,
cord-007689-0vpp3xdl	313	29	as	as	RB
cord-007689-0vpp3xdl	313	30	well	well	RB
cord-007689-0vpp3xdl	313	31	as	as	IN
cord-007689-0vpp3xdl	313	32	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	313	33	-/mice	-/mice	ADD
cord-007689-0vpp3xdl	313	34	stimulated	stimulate	VBN
cord-007689-0vpp3xdl	313	35	in	in	IN
cord-007689-0vpp3xdl	313	36	vivo	vivo	NN
cord-007689-0vpp3xdl	313	37	were	be	VBD
cord-007689-0vpp3xdl	313	38	found	find	VBN
cord-007689-0vpp3xdl	313	39	unable	unable	JJ
cord-007689-0vpp3xdl	313	40	to	to	TO
cord-007689-0vpp3xdl	313	41	mount	mount	VB
cord-007689-0vpp3xdl	313	42	a	a	DT
cord-007689-0vpp3xdl	313	43	type	type	NN
cord-007689-0vpp3xdl	314	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	314	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	314	3	response	response	NN
cord-007689-0vpp3xdl	314	4	to	to	IN
cord-007689-0vpp3xdl	314	5	poly	poly	NNP
cord-007689-0vpp3xdl	315	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	315	2	:	:	:
cord-007689-0vpp3xdl	315	3	C	C	NNP
cord-007689-0vpp3xdl	315	4	,	,	,
cord-007689-0vpp3xdl	315	5	establishing	establish	VBG
cord-007689-0vpp3xdl	315	6	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	315	7	,	,	,
cord-007689-0vpp3xdl	315	8	rather	rather	RB
cord-007689-0vpp3xdl	315	9	than	than	IN
cord-007689-0vpp3xdl	315	10	the	the	DT
cord-007689-0vpp3xdl	315	11	several	several	JJ
cord-007689-0vpp3xdl	315	12	other	other	JJ
cord-007689-0vpp3xdl	315	13	receptors	receptor	NNS
cord-007689-0vpp3xdl	315	14	that	that	WDT
cord-007689-0vpp3xdl	315	15	bind	bind	VBP
cord-007689-0vpp3xdl	315	16	,	,	,
cord-007689-0vpp3xdl	315	17	or	or	CC
cord-007689-0vpp3xdl	315	18	have	have	VBP
cord-007689-0vpp3xdl	315	19	been	be	VBN
cord-007689-0vpp3xdl	315	20	shown	show	VBN
cord-007689-0vpp3xdl	315	21	to	to	TO
cord-007689-0vpp3xdl	315	22	be	be	VB
cord-007689-0vpp3xdl	315	23	activated	activate	VBN
cord-007689-0vpp3xdl	315	24	by	by	IN
cord-007689-0vpp3xdl	315	25	poly	poly	NNP
cord-007689-0vpp3xdl	315	26	I	I	NNP
cord-007689-0vpp3xdl	315	27	:	:	:
cord-007689-0vpp3xdl	315	28	C	C	NNP
cord-007689-0vpp3xdl	315	29	,	,	,
cord-007689-0vpp3xdl	315	30	as	as	IN
cord-007689-0vpp3xdl	315	31	the	the	DT
cord-007689-0vpp3xdl	315	32	dominant	dominant	JJ
cord-007689-0vpp3xdl	315	33	receptor	receptor	NN
cord-007689-0vpp3xdl	315	34	mediating	mediate	VBG
cord-007689-0vpp3xdl	315	35	the	the	DT
cord-007689-0vpp3xdl	315	36	interferon	interferon	NN
cord-007689-0vpp3xdl	315	37	response	response	NN
cord-007689-0vpp3xdl	315	38	to	to	IN
cord-007689-0vpp3xdl	315	39	poly	poly	NNP
cord-007689-0vpp3xdl	316	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	316	2	:	:	:
cord-007689-0vpp3xdl	316	3	C	C	NNP
cord-007689-0vpp3xdl	316	4	(	(	-LRB-
cord-007689-0vpp3xdl	316	5	Gitlin	Gitlin	NNP
cord-007689-0vpp3xdl	316	6	et	et	FW
cord-007689-0vpp3xdl	316	7	al	al	NNP
cord-007689-0vpp3xdl	316	8	.	.	.
cord-007689-0vpp3xdl	316	9	2006	2006	CD
cord-007689-0vpp3xdl	316	10	;	;	:
cord-007689-0vpp3xdl	316	11	Kato	Kato	NNP
cord-007689-0vpp3xdl	316	12	et	et	NNP
cord-007689-0vpp3xdl	316	13	al	al	NNP
cord-007689-0vpp3xdl	316	14	.	.	.
cord-007689-0vpp3xdl	316	15	2006	2006	CD
cord-007689-0vpp3xdl	316	16	)	)	-RRB-
cord-007689-0vpp3xdl	316	17	.	.	.
cord-007689-0vpp3xdl	317	1	However	however	RB
cord-007689-0vpp3xdl	317	2	,	,	,
cord-007689-0vpp3xdl	317	3	the	the	DT
cord-007689-0vpp3xdl	317	4	natural	natural	JJ
cord-007689-0vpp3xdl	317	5	viral	viral	JJ
cord-007689-0vpp3xdl	317	6	ligand	ligand	NN
cord-007689-0vpp3xdl	317	7	for	for	IN
cord-007689-0vpp3xdl	317	8	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	317	9	has	have	VBZ
cord-007689-0vpp3xdl	317	10	not	not	RB
cord-007689-0vpp3xdl	317	11	yet	yet	RB
cord-007689-0vpp3xdl	317	12	been	be	VBN
cord-007689-0vpp3xdl	317	13	identified	identify	VBN
cord-007689-0vpp3xdl	317	14	.	.	.
cord-007689-0vpp3xdl	318	1	In	in	IN
cord-007689-0vpp3xdl	318	2	addition	addition	NN
cord-007689-0vpp3xdl	318	3	to	to	IN
cord-007689-0vpp3xdl	318	4	RIG	rig	NN
cord-007689-0vpp3xdl	318	5	-	-	:
cord-007689-0vpp3xdl	318	6	I	-PRON-	PRP
cord-007689-0vpp3xdl	318	7	and	and	CC
cord-007689-0vpp3xdl	318	8	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	318	9	,	,	,
cord-007689-0vpp3xdl	318	10	another	another	DT
cord-007689-0vpp3xdl	318	11	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	318	12	receptor	receptor	NN
cord-007689-0vpp3xdl	318	13	may	may	MD
cord-007689-0vpp3xdl	318	14	exist	exist	VB
cord-007689-0vpp3xdl	318	15	for	for	IN
cord-007689-0vpp3xdl	318	16	detecting	detect	VBG
cord-007689-0vpp3xdl	318	17	DNA	dna	NN
cord-007689-0vpp3xdl	318	18	.	.	.
cord-007689-0vpp3xdl	319	1	Until	until	IN
cord-007689-0vpp3xdl	319	2	recently	recently	RB
cord-007689-0vpp3xdl	319	3	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	319	4	was	be	VBD
cord-007689-0vpp3xdl	319	5	the	the	DT
cord-007689-0vpp3xdl	319	6	only	only	JJ
cord-007689-0vpp3xdl	319	7	innate	innate	JJ
cord-007689-0vpp3xdl	319	8	sensor	sensor	NN
cord-007689-0vpp3xdl	319	9	for	for	IN
cord-007689-0vpp3xdl	319	10	detecting	detect	VBG
cord-007689-0vpp3xdl	319	11	microbial	microbial	JJ
cord-007689-0vpp3xdl	319	12	DNA	dna	NN
cord-007689-0vpp3xdl	319	13	.	.	.
cord-007689-0vpp3xdl	320	1	Recent	recent	JJ
cord-007689-0vpp3xdl	320	2	studies	study	NNS
cord-007689-0vpp3xdl	320	3	indicate	indicate	VBP
cord-007689-0vpp3xdl	320	4	that	that	IN
cord-007689-0vpp3xdl	320	5	DNA	DNA	NNP
cord-007689-0vpp3xdl	320	6	is	be	VBZ
cord-007689-0vpp3xdl	320	7	detected	detect	VBN
cord-007689-0vpp3xdl	320	8	in	in	IN
cord-007689-0vpp3xdl	320	9	the	the	DT
cord-007689-0vpp3xdl	320	10	cytosol	cytosol	NN
cord-007689-0vpp3xdl	320	11	independently	independently	RB
cord-007689-0vpp3xdl	320	12	of	of	IN
cord-007689-0vpp3xdl	320	13	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	320	14	(	(	-LRB-
cord-007689-0vpp3xdl	320	15	Okabe	Okabe	NNP
cord-007689-0vpp3xdl	320	16	et	et	NNP
cord-007689-0vpp3xdl	320	17	al	al	NNP
cord-007689-0vpp3xdl	320	18	.	.	NNP
cord-007689-0vpp3xdl	320	19	2005	2005	CD
cord-007689-0vpp3xdl	320	20	;	;	:
cord-007689-0vpp3xdl	320	21	Stetson	Stetson	NNP
cord-007689-0vpp3xdl	320	22	and	and	CC
cord-007689-0vpp3xdl	320	23	Medzhitov	Medzhitov	NNP
cord-007689-0vpp3xdl	320	24	2006	2006	CD
cord-007689-0vpp3xdl	320	25	)	)	-RRB-
cord-007689-0vpp3xdl	320	26	,	,	,
cord-007689-0vpp3xdl	320	27	but	but	CC
cord-007689-0vpp3xdl	320	28	the	the	DT
cord-007689-0vpp3xdl	320	29	receptor	receptor	NN
cord-007689-0vpp3xdl	320	30	has	have	VBZ
cord-007689-0vpp3xdl	320	31	not	not	RB
cord-007689-0vpp3xdl	320	32	been	be	VBN
cord-007689-0vpp3xdl	320	33	identified	identify	VBN
cord-007689-0vpp3xdl	320	34	yet	yet	RB
cord-007689-0vpp3xdl	320	35	.	.	.
cord-007689-0vpp3xdl	321	1	The	the	DT
cord-007689-0vpp3xdl	321	2	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	321	3	receptor	receptor	NN
cord-007689-0vpp3xdl	321	4	mediating	mediate	VBG
cord-007689-0vpp3xdl	321	5	recognition	recognition	NN
cord-007689-0vpp3xdl	321	6	of	of	IN
cord-007689-0vpp3xdl	321	7	B	b	NN
cord-007689-0vpp3xdl	321	8	-	-	HYPH
cord-007689-0vpp3xdl	321	9	form	form	NN
cord-007689-0vpp3xdl	321	10	DNA	dna	NN
cord-007689-0vpp3xdl	321	11	,	,	,
cord-007689-0vpp3xdl	321	12	unlike	unlike	IN
cord-007689-0vpp3xdl	321	13	RIG	rig	NN
cord-007689-0vpp3xdl	321	14	-	-	:
cord-007689-0vpp3xdl	321	15	I	I	NNP
cord-007689-0vpp3xdl	321	16	and	and	CC
cord-007689-0vpp3xdl	321	17	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	321	18	,	,	,
cord-007689-0vpp3xdl	321	19	signals	signal	NNS
cord-007689-0vpp3xdl	321	20	independently	independently	RB
cord-007689-0vpp3xdl	321	21	of	of	IN
cord-007689-0vpp3xdl	321	22	IPS-1	IPS-1	NNP
cord-007689-0vpp3xdl	321	23	.	.	.
cord-007689-0vpp3xdl	322	1	As	as	IN
cord-007689-0vpp3xdl	322	2	discussed	discuss	VBN
cord-007689-0vpp3xdl	322	3	in	in	IN
cord-007689-0vpp3xdl	322	4	the	the	DT
cord-007689-0vpp3xdl	322	5	previous	previous	JJ
cord-007689-0vpp3xdl	322	6	sections	section	NNS
cord-007689-0vpp3xdl	322	7	,	,	,
cord-007689-0vpp3xdl	322	8	immune	immune	JJ
cord-007689-0vpp3xdl	322	9	and	and	CC
cord-007689-0vpp3xdl	322	10	nonimmune	nonimmune	JJ
cord-007689-0vpp3xdl	322	11	cell	cell	NN
cord-007689-0vpp3xdl	322	12	types	type	NNS
cord-007689-0vpp3xdl	322	13	express	express	VBP
cord-007689-0vpp3xdl	322	14	characteristic	characteristic	JJ
cord-007689-0vpp3xdl	322	15	patterns	pattern	NNS
cord-007689-0vpp3xdl	322	16	of	of	IN
cord-007689-0vpp3xdl	322	17	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	322	18	acid	acid	NN
cord-007689-0vpp3xdl	322	19	receptors	receptor	NNS
cord-007689-0vpp3xdl	322	20	(	(	-LRB-
cord-007689-0vpp3xdl	322	21	Table	table	NN
cord-007689-0vpp3xdl	322	22	1	1	CD
cord-007689-0vpp3xdl	322	23	)	)	-RRB-
cord-007689-0vpp3xdl	322	24	.	.	.
cord-007689-0vpp3xdl	323	1	For	for	IN
cord-007689-0vpp3xdl	323	2	example	example	NN
cord-007689-0vpp3xdl	323	3	,	,	,
cord-007689-0vpp3xdl	323	4	Melchjorsen	Melchjorsen	NNP
cord-007689-0vpp3xdl	323	5	and	and	CC
cord-007689-0vpp3xdl	323	6	colleagues	colleague	NNS
cord-007689-0vpp3xdl	323	7	reported	report	VBD
cord-007689-0vpp3xdl	323	8	that	that	IN
cord-007689-0vpp3xdl	323	9	activation	activation	NN
cord-007689-0vpp3xdl	323	10	of	of	IN
cord-007689-0vpp3xdl	323	11	innate	innate	JJ
cord-007689-0vpp3xdl	323	12	defense	defense	NN
cord-007689-0vpp3xdl	323	13	against	against	IN
cord-007689-0vpp3xdl	323	14	a	a	DT
cord-007689-0vpp3xdl	323	15	paramyxovirus	paramyxovirus	NN
cord-007689-0vpp3xdl	323	16	is	be	VBZ
cord-007689-0vpp3xdl	323	17	mediated	mediate	VBN
cord-007689-0vpp3xdl	323	18	by	by	IN
cord-007689-0vpp3xdl	323	19	RIG	rig	NN
cord-007689-0vpp3xdl	323	20	-	-	:
cord-007689-0vpp3xdl	323	21	I	I	NNP
cord-007689-0vpp3xdl	323	22	,	,	,
cord-007689-0vpp3xdl	323	23	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	323	24	,	,	,
cord-007689-0vpp3xdl	323	25	and	and	CC
cord-007689-0vpp3xdl	323	26	TLR8	TLR8	NNP
cord-007689-0vpp3xdl	323	27	in	in	IN
cord-007689-0vpp3xdl	323	28	a	a	DT
cord-007689-0vpp3xdl	323	29	cell	cell	NN
cord-007689-0vpp3xdl	323	30	-	-	HYPH
cord-007689-0vpp3xdl	323	31	type	type	NN
cord-007689-0vpp3xdl	323	32	-	-	HYPH
cord-007689-0vpp3xdl	323	33	specific	specific	JJ
cord-007689-0vpp3xdl	323	34	manner	manner	NN
cord-007689-0vpp3xdl	324	1	(	(	-LRB-
cord-007689-0vpp3xdl	324	2	Melchjorsen	Melchjorsen	NNP
cord-007689-0vpp3xdl	324	3	et	et	NNP
cord-007689-0vpp3xdl	324	4	al	al	NNP
cord-007689-0vpp3xdl	324	5	.	.	NNP
cord-007689-0vpp3xdl	324	6	2005	2005	CD
cord-007689-0vpp3xdl	324	7	)	)	-RRB-
cord-007689-0vpp3xdl	324	8	.	.	.
cord-007689-0vpp3xdl	325	1	They	-PRON-	PRP
cord-007689-0vpp3xdl	325	2	found	find	VBD
cord-007689-0vpp3xdl	325	3	that	that	IN
cord-007689-0vpp3xdl	325	4	nonimmune	nonimmune	JJ
cord-007689-0vpp3xdl	325	5	cells	cell	NNS
cord-007689-0vpp3xdl	325	6	relied	rely	VBD
cord-007689-0vpp3xdl	325	7	entirely	entirely	RB
cord-007689-0vpp3xdl	325	8	on	on	IN
cord-007689-0vpp3xdl	325	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	325	10	recognition	recognition	NN
cord-007689-0vpp3xdl	325	11	through	through	IN
cord-007689-0vpp3xdl	325	12	RIG	rig	NN
cord-007689-0vpp3xdl	325	13	-	-	:
cord-007689-0vpp3xdl	325	14	I	-PRON-	PRP
cord-007689-0vpp3xdl	325	15	for	for	IN
cord-007689-0vpp3xdl	325	16	activation	activation	NN
cord-007689-0vpp3xdl	325	17	of	of	IN
cord-007689-0vpp3xdl	325	18	an	an	DT
cord-007689-0vpp3xdl	325	19	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	325	20	response	response	NN
cord-007689-0vpp3xdl	325	21	.	.	.
cord-007689-0vpp3xdl	326	1	In	in	IN
cord-007689-0vpp3xdl	326	2	contrast	contrast	NN
cord-007689-0vpp3xdl	326	3	,	,	,
cord-007689-0vpp3xdl	326	4	immune	immune	JJ
cord-007689-0vpp3xdl	326	5	cells	cell	NNS
cord-007689-0vpp3xdl	326	6	such	such	JJ
cord-007689-0vpp3xdl	326	7	as	as	IN
cord-007689-0vpp3xdl	326	8	myeloid	myeloid	NN
cord-007689-0vpp3xdl	326	9	cells	cell	NNS
cord-007689-0vpp3xdl	326	10	utilized	utilize	VBN
cord-007689-0vpp3xdl	326	11	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	326	12	and	and	CC
cord-007689-0vpp3xdl	326	13	TLR8	TLR8	NNP
cord-007689-0vpp3xdl	326	14	.	.	.
cord-007689-0vpp3xdl	327	1	Unlike	unlike	IN
cord-007689-0vpp3xdl	327	2	Modifications	modification	NNS
cord-007689-0vpp3xdl	327	3	that	that	WDT
cord-007689-0vpp3xdl	327	4	have	have	VBP
cord-007689-0vpp3xdl	327	5	been	be	VBN
cord-007689-0vpp3xdl	327	6	shown	show	VBN
cord-007689-0vpp3xdl	327	7	to	to	TO
cord-007689-0vpp3xdl	327	8	prevent	prevent	VB
cord-007689-0vpp3xdl	327	9	detection	detection	NN
cord-007689-0vpp3xdl	327	10	by	by	IN
cord-007689-0vpp3xdl	327	11	the	the	DT
cord-007689-0vpp3xdl	327	12	receptors	receptor	NNS
cord-007689-0vpp3xdl	327	13	indicated	indicate	VBN
cord-007689-0vpp3xdl	327	14	and	and	CC
cord-007689-0vpp3xdl	327	15	that	that	WDT
cord-007689-0vpp3xdl	327	16	are	be	VBP
cord-007689-0vpp3xdl	327	17	frequently	frequently	RB
cord-007689-0vpp3xdl	327	18	found	find	VBN
cord-007689-0vpp3xdl	327	19	in	in	IN
cord-007689-0vpp3xdl	327	20	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	327	21	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	327	22	acids	acid	NNS
cord-007689-0vpp3xdl	327	23	in	in	IN
cord-007689-0vpp3xdl	327	24	nonimmune	nonimmune	JJ
cord-007689-0vpp3xdl	327	25	cells	cell	NNS
cord-007689-0vpp3xdl	327	26	,	,	,
cord-007689-0vpp3xdl	327	27	RNA	RNA	NNP
cord-007689-0vpp3xdl	327	28	sensing	sensing	NN
cord-007689-0vpp3xdl	327	29	in	in	IN
cord-007689-0vpp3xdl	327	30	paramyxovirus	paramyxovirus	NN
cord-007689-0vpp3xdl	327	31	-	-	HYPH
cord-007689-0vpp3xdl	327	32	infected	infect	VBN
cord-007689-0vpp3xdl	327	33	myeloid	myeloid	NN
cord-007689-0vpp3xdl	327	34	cells	cell	NNS
cord-007689-0vpp3xdl	327	35	was	be	VBD
cord-007689-0vpp3xdl	327	36	independent	independent	JJ
cord-007689-0vpp3xdl	327	37	of	of	IN
cord-007689-0vpp3xdl	327	38	RIG	rig	NN
cord-007689-0vpp3xdl	327	39	-	-	:
cord-007689-0vpp3xdl	327	40	I	I	NNP
cord-007689-0vpp3xdl	327	41	,	,	,
cord-007689-0vpp3xdl	327	42	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	327	43	,	,	,
cord-007689-0vpp3xdl	327	44	and	and	CC
cord-007689-0vpp3xdl	327	45	PKR	PKR	NNP
cord-007689-0vpp3xdl	327	46	.	.	.
cord-007689-0vpp3xdl	328	1	Kato	Kato	NNP
cord-007689-0vpp3xdl	328	2	and	and	CC
cord-007689-0vpp3xdl	328	3	colleagues	colleague	NNS
cord-007689-0vpp3xdl	328	4	also	also	RB
cord-007689-0vpp3xdl	328	5	found	find	VBD
cord-007689-0vpp3xdl	328	6	celltype	celltype	NN
cord-007689-0vpp3xdl	328	7	specific	specific	JJ
cord-007689-0vpp3xdl	328	8	involvement	involvement	NN
cord-007689-0vpp3xdl	328	9	of	of	IN
cord-007689-0vpp3xdl	328	10	RIG	rig	NN
cord-007689-0vpp3xdl	328	11	-	-	:
cord-007689-0vpp3xdl	328	12	I	-PRON-	PRP
cord-007689-0vpp3xdl	328	13	in	in	IN
cord-007689-0vpp3xdl	328	14	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	328	15	immune	immune	JJ
cord-007689-0vpp3xdl	328	16	response	response	NN
cord-007689-0vpp3xdl	328	17	.	.	.
cord-007689-0vpp3xdl	329	1	In	in	IN
cord-007689-0vpp3xdl	329	2	their	-PRON-	PRP$
cord-007689-0vpp3xdl	329	3	study	study	NN
cord-007689-0vpp3xdl	329	4	type	type	NN
cord-007689-0vpp3xdl	329	5	I	-PRON-	PRP
cord-007689-0vpp3xdl	329	6	IFN	IFN	NNP
cord-007689-0vpp3xdl	329	7	induction	induction	NN
cord-007689-0vpp3xdl	329	8	in	in	IN
cord-007689-0vpp3xdl	329	9	both	both	DT
cord-007689-0vpp3xdl	329	10	fibroblasts	fibroblast	NNS
cord-007689-0vpp3xdl	329	11	and	and	CC
cord-007689-0vpp3xdl	329	12	myeloid	myeloid	JJ
cord-007689-0vpp3xdl	329	13	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	329	14	cells	cell	NNS
cord-007689-0vpp3xdl	329	15	was	be	VBD
cord-007689-0vpp3xdl	329	16	RIG	rig	NN
cord-007689-0vpp3xdl	329	17	-	-	HYPH
cord-007689-0vpp3xdl	329	18	I	i	NN
cord-007689-0vpp3xdl	329	19	-	-	HYPH
cord-007689-0vpp3xdl	329	20	dependent	dependent	JJ
cord-007689-0vpp3xdl	329	21	,	,	,
cord-007689-0vpp3xdl	329	22	while	while	IN
cord-007689-0vpp3xdl	329	23	type	type	NN
cord-007689-0vpp3xdl	329	24	I	-PRON-	PRP
cord-007689-0vpp3xdl	329	25	IFN	IFN	NNP
cord-007689-0vpp3xdl	329	26	induction	induction	NN
cord-007689-0vpp3xdl	329	27	in	in	IN
cord-007689-0vpp3xdl	329	28	PDC	PDC	NNP
cord-007689-0vpp3xdl	329	29	was	be	VBD
cord-007689-0vpp3xdl	329	30	RIG	rig	NN
cord-007689-0vpp3xdl	329	31	-	-	HYPH
cord-007689-0vpp3xdl	329	32	I	i	NN
cord-007689-0vpp3xdl	329	33	-	-	HYPH
cord-007689-0vpp3xdl	329	34	independent	independent	JJ
cord-007689-0vpp3xdl	329	35	.	.	.
cord-007689-0vpp3xdl	330	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	330	2	is	be	VBZ
cord-007689-0vpp3xdl	330	3	important	important	JJ
cord-007689-0vpp3xdl	330	4	to	to	TO
cord-007689-0vpp3xdl	330	5	note	note	VB
cord-007689-0vpp3xdl	330	6	that	that	IN
cord-007689-0vpp3xdl	330	7	the	the	DT
cord-007689-0vpp3xdl	330	8	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	330	9	used	use	VBN
cord-007689-0vpp3xdl	330	10	for	for	IN
cord-007689-0vpp3xdl	330	11	RNA	RNA	NNP
cord-007689-0vpp3xdl	330	12	sensing	sensing	NN
cord-007689-0vpp3xdl	330	13	may	may	MD
cord-007689-0vpp3xdl	330	14	not	not	RB
cord-007689-0vpp3xdl	330	15	only	only	RB
cord-007689-0vpp3xdl	330	16	be	be	VB
cord-007689-0vpp3xdl	330	17	cell	cell	NN
cord-007689-0vpp3xdl	330	18	-	-	HYPH
cord-007689-0vpp3xdl	330	19	type	type	NN
cord-007689-0vpp3xdl	330	20	-	-	HYPH
cord-007689-0vpp3xdl	330	21	dependent	dependent	JJ
cord-007689-0vpp3xdl	330	22	but	but	CC
cord-007689-0vpp3xdl	330	23	may	may	MD
cord-007689-0vpp3xdl	330	24	also	also	RB
cord-007689-0vpp3xdl	330	25	depend	depend	VB
cord-007689-0vpp3xdl	330	26	on	on	IN
cord-007689-0vpp3xdl	330	27	the	the	DT
cord-007689-0vpp3xdl	330	28	type	type	NN
cord-007689-0vpp3xdl	330	29	of	of	IN
cord-007689-0vpp3xdl	330	30	virus	virus	NN
cord-007689-0vpp3xdl	330	31	and	and	CC
cord-007689-0vpp3xdl	330	32	its	-PRON-	PRP$
cord-007689-0vpp3xdl	330	33	strategy	strategy	NN
cord-007689-0vpp3xdl	330	34	to	to	TO
cord-007689-0vpp3xdl	330	35	enter	enter	VB
cord-007689-0vpp3xdl	330	36	the	the	DT
cord-007689-0vpp3xdl	330	37	target	target	NN
cord-007689-0vpp3xdl	330	38	cell	cell	NN
cord-007689-0vpp3xdl	330	39	and	and	CC
cord-007689-0vpp3xdl	330	40	to	to	TO
cord-007689-0vpp3xdl	330	41	evade	evade	VB
cord-007689-0vpp3xdl	330	42	immune	immune	JJ
cord-007689-0vpp3xdl	330	43	recognition	recognition	NN
cord-007689-0vpp3xdl	330	44	.	.	.
cord-007689-0vpp3xdl	331	1	In	in	IN
cord-007689-0vpp3xdl	331	2	contrast	contrast	NN
cord-007689-0vpp3xdl	331	3	,	,	,
cord-007689-0vpp3xdl	331	4	recognition	recognition	NN
cord-007689-0vpp3xdl	331	5	of	of	IN
cord-007689-0vpp3xdl	331	6	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	331	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	331	8	or	or	CC
cord-007689-0vpp3xdl	331	9	of	of	IN
cord-007689-0vpp3xdl	331	10	RNA	RNA	NNP
cord-007689-0vpp3xdl	331	11	transcribed	transcribe	VBN
cord-007689-0vpp3xdl	331	12	from	from	IN
cord-007689-0vpp3xdl	331	13	vector	vector	NN
cord-007689-0vpp3xdl	331	14	systems	system	NNS
cord-007689-0vpp3xdl	331	15	is	be	VBZ
cord-007689-0vpp3xdl	331	16	more	more	RBR
cord-007689-0vpp3xdl	331	17	predictable	predictable	JJ
cord-007689-0vpp3xdl	331	18	because	because	IN
cord-007689-0vpp3xdl	331	19	there	there	EX
cord-007689-0vpp3xdl	331	20	is	be	VBZ
cord-007689-0vpp3xdl	331	21	no	no	DT
cord-007689-0vpp3xdl	331	22	immune	immune	JJ
cord-007689-0vpp3xdl	331	23	evasion	evasion	NN
cord-007689-0vpp3xdl	331	24	and	and	CC
cord-007689-0vpp3xdl	331	25	because	because	IN
cord-007689-0vpp3xdl	331	26	the	the	DT
cord-007689-0vpp3xdl	331	27	mode	mode	NN
cord-007689-0vpp3xdl	331	28	of	of	IN
cord-007689-0vpp3xdl	331	29	delivery	delivery	NN
cord-007689-0vpp3xdl	331	30	is	be	VBZ
cord-007689-0vpp3xdl	331	31	known	know	VBN
cord-007689-0vpp3xdl	331	32	.	.	.
cord-007689-0vpp3xdl	332	1	Of	of	IN
cord-007689-0vpp3xdl	332	2	note	note	NN
cord-007689-0vpp3xdl	332	3	,	,	,
cord-007689-0vpp3xdl	332	4	the	the	DT
cord-007689-0vpp3xdl	332	5	use	use	NN
cord-007689-0vpp3xdl	332	6	of	of	IN
cord-007689-0vpp3xdl	332	7	cationic	cationic	JJ
cord-007689-0vpp3xdl	332	8	lipids	lipid	NNS
cord-007689-0vpp3xdl	332	9	and	and	CC
cord-007689-0vpp3xdl	332	10	polycationes	polycationes	NNP
cord-007689-0vpp3xdl	332	11	leads	lead	VBZ
cord-007689-0vpp3xdl	332	12	to	to	IN
cord-007689-0vpp3xdl	332	13	both	both	DT
cord-007689-0vpp3xdl	332	14	endosomal	endosomal	JJ
cord-007689-0vpp3xdl	332	15	and	and	CC
cord-007689-0vpp3xdl	332	16	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	332	17	delivery	delivery	NN
cord-007689-0vpp3xdl	333	1	(	(	-LRB-
cord-007689-0vpp3xdl	333	2	Almofti	Almofti	NNP
cord-007689-0vpp3xdl	333	3	et	et	FW
cord-007689-0vpp3xdl	333	4	al	al	NNP
cord-007689-0vpp3xdl	333	5	.	.	.
cord-007689-0vpp3xdl	334	1	2003	2003	CD
cord-007689-0vpp3xdl	334	2	;	;	:
cord-007689-0vpp3xdl	334	3	Boussif	Boussif	NNP
cord-007689-0vpp3xdl	334	4	et	et	FW
cord-007689-0vpp3xdl	334	5	al	al	NNP
cord-007689-0vpp3xdl	334	6	.	.	NNP
cord-007689-0vpp3xdl	334	7	1995	1995	CD
cord-007689-0vpp3xdl	334	8	)	)	-RRB-
cord-007689-0vpp3xdl	335	1	and	and	CC
cord-007689-0vpp3xdl	335	2	thus	thus	RB
cord-007689-0vpp3xdl	335	3	both	both	DT
cord-007689-0vpp3xdl	335	4	TLR	TLR	NNP
cord-007689-0vpp3xdl	335	5	-	-	:
cord-007689-0vpp3xdl	335	6	and	and	CC
cord-007689-0vpp3xdl	335	7	RIG	rig	NN
cord-007689-0vpp3xdl	335	8	-	-	HYPH
cord-007689-0vpp3xdl	335	9	I	i	NN
cord-007689-0vpp3xdl	335	10	-	-	HYPH
cord-007689-0vpp3xdl	335	11	mediated	mediate	VBN
cord-007689-0vpp3xdl	335	12	RNA	RNA	NNP
cord-007689-0vpp3xdl	335	13	sensing	sensing	NN
cord-007689-0vpp3xdl	335	14	is	be	VBZ
cord-007689-0vpp3xdl	335	15	triggered	trigger	VBN
cord-007689-0vpp3xdl	335	16	,	,	,
cord-007689-0vpp3xdl	335	17	provided	provide	VBD
cord-007689-0vpp3xdl	335	18	these	these	DT
cord-007689-0vpp3xdl	335	19	receptors	receptor	NNS
cord-007689-0vpp3xdl	335	20	are	be	VBP
cord-007689-0vpp3xdl	335	21	expressed	express	VBN
cord-007689-0vpp3xdl	335	22	in	in	IN
cord-007689-0vpp3xdl	335	23	the	the	DT
cord-007689-0vpp3xdl	335	24	cell	cell	NN
cord-007689-0vpp3xdl	335	25	type	type	NN
cord-007689-0vpp3xdl	335	26	examined	examine	VBN
cord-007689-0vpp3xdl	335	27	,	,	,
cord-007689-0vpp3xdl	335	28	and	and	CC
cord-007689-0vpp3xdl	335	29	the	the	DT
cord-007689-0vpp3xdl	335	30	appropriate	appropriate	JJ
cord-007689-0vpp3xdl	335	31	RNA	RNA	NNP
cord-007689-0vpp3xdl	335	32	ligand	ligand	NN
cord-007689-0vpp3xdl	335	33	is	be	VBZ
cord-007689-0vpp3xdl	335	34	delivered	deliver	VBN
cord-007689-0vpp3xdl	335	35	.	.	.
cord-007689-0vpp3xdl	336	1	Of	of	IN
cord-007689-0vpp3xdl	336	2	note	note	NN
cord-007689-0vpp3xdl	336	3	,	,	,
cord-007689-0vpp3xdl	336	4	subcellular	subcellular	JJ
cord-007689-0vpp3xdl	336	5	localization	localization	NN
cord-007689-0vpp3xdl	336	6	of	of	IN
cord-007689-0vpp3xdl	336	7	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	336	8	is	be	VBZ
cord-007689-0vpp3xdl	336	9	cell	cell	NN
cord-007689-0vpp3xdl	336	10	-	-	HYPH
cord-007689-0vpp3xdl	336	11	type	type	NN
cord-007689-0vpp3xdl	336	12	-	-	HYPH
cord-007689-0vpp3xdl	336	13	specific	specific	JJ
cord-007689-0vpp3xdl	336	14	(	(	-LRB-
cord-007689-0vpp3xdl	336	15	Matsumoto	Matsumoto	NNP
cord-007689-0vpp3xdl	336	16	et	et	NNP
cord-007689-0vpp3xdl	336	17	al	al	NNP
cord-007689-0vpp3xdl	336	18	.	.	NNP
cord-007689-0vpp3xdl	336	19	2003	2003	CD
cord-007689-0vpp3xdl	336	20	)	)	-RRB-
cord-007689-0vpp3xdl	336	21	:	:	:
cord-007689-0vpp3xdl	337	1	in	in	IN
cord-007689-0vpp3xdl	337	2	fibroblasts	fibroblast	NNS
cord-007689-0vpp3xdl	337	3	,	,	,
cord-007689-0vpp3xdl	337	4	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	337	5	is	be	VBZ
cord-007689-0vpp3xdl	337	6	located	locate	VBN
cord-007689-0vpp3xdl	337	7	on	on	IN
cord-007689-0vpp3xdl	337	8	the	the	DT
cord-007689-0vpp3xdl	337	9	cell	cell	NN
cord-007689-0vpp3xdl	337	10	surface	surface	NN
cord-007689-0vpp3xdl	337	11	,	,	,
cord-007689-0vpp3xdl	337	12	and	and	CC
cord-007689-0vpp3xdl	337	13	the	the	DT
cord-007689-0vpp3xdl	337	14	TLR3-mediated	tlr3-mediated	JJ
cord-007689-0vpp3xdl	337	15	activity	activity	NN
cord-007689-0vpp3xdl	337	16	can	can	MD
cord-007689-0vpp3xdl	337	17	be	be	VB
cord-007689-0vpp3xdl	337	18	blocked	block	VBN
cord-007689-0vpp3xdl	337	19	by	by	IN
cord-007689-0vpp3xdl	337	20	anti	anti	JJ
cord-007689-0vpp3xdl	337	21	-	-	JJ
cord-007689-0vpp3xdl	337	22	TLR3	tlr3	JJ
cord-007689-0vpp3xdl	337	23	antibodies	antibody	NNS
cord-007689-0vpp3xdl	337	24	.	.	.
cord-007689-0vpp3xdl	338	1	In	in	IN
cord-007689-0vpp3xdl	338	2	myeloid	myeloid	JJ
cord-007689-0vpp3xdl	338	3	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	338	4	cells	cell	NNS
cord-007689-0vpp3xdl	338	5	,	,	,
cord-007689-0vpp3xdl	338	6	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	338	7	is	be	VBZ
cord-007689-0vpp3xdl	338	8	found	find	VBN
cord-007689-0vpp3xdl	338	9	in	in	IN
cord-007689-0vpp3xdl	338	10	the	the	DT
cord-007689-0vpp3xdl	338	11	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	338	12	compartment	compartment	NN
cord-007689-0vpp3xdl	338	13	.	.	.
cord-007689-0vpp3xdl	339	1	A	a	DT
cord-007689-0vpp3xdl	339	2	more	more	RBR
cord-007689-0vpp3xdl	339	3	detailed	detailed	JJ
cord-007689-0vpp3xdl	339	4	analysis	analysis	NN
cord-007689-0vpp3xdl	339	5	in	in	IN
cord-007689-0vpp3xdl	339	6	TLR3-transfected	TLR3-transfected	NNP
cord-007689-0vpp3xdl	339	7	B	B	NNP
cord-007689-0vpp3xdl	339	8	cells	cell	NNS
cord-007689-0vpp3xdl	339	9	revealed	reveal	VBD
cord-007689-0vpp3xdl	339	10	that	that	IN
cord-007689-0vpp3xdl	339	11	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	339	12	is	be	VBZ
cord-007689-0vpp3xdl	339	13	detectable	detectable	JJ
cord-007689-0vpp3xdl	339	14	in	in	IN
cord-007689-0vpp3xdl	339	15	multivesicular	multivesicular	JJ
cord-007689-0vpp3xdl	339	16	bodies	body	NNS
cord-007689-0vpp3xdl	339	17	,	,	,
cord-007689-0vpp3xdl	339	18	a	a	DT
cord-007689-0vpp3xdl	339	19	subcellular	subcellular	JJ
cord-007689-0vpp3xdl	339	20	compartment	compartment	NN
cord-007689-0vpp3xdl	339	21	situated	situate	VBN
cord-007689-0vpp3xdl	339	22	in	in	IN
cord-007689-0vpp3xdl	339	23	the	the	DT
cord-007689-0vpp3xdl	339	24	endocytic	endocytic	JJ
cord-007689-0vpp3xdl	339	25	trafficking	traffic	VBG
cord-007689-0vpp3xdl	339	26	pathway	pathway	NN
cord-007689-0vpp3xdl	339	27	(	(	-LRB-
cord-007689-0vpp3xdl	339	28	Matsumoto	Matsumoto	NNP
cord-007689-0vpp3xdl	339	29	et	et	NNP
cord-007689-0vpp3xdl	339	30	al	al	NNP
cord-007689-0vpp3xdl	339	31	.	.	NNP
cord-007689-0vpp3xdl	339	32	2003	2003	CD
cord-007689-0vpp3xdl	339	33	)	)	-RRB-
cord-007689-0vpp3xdl	339	34	.	.	.
cord-007689-0vpp3xdl	340	1	Bacteria	Bacteria	NNS
cord-007689-0vpp3xdl	340	2	,	,	,
cord-007689-0vpp3xdl	340	3	fungi	fungus	NNS
cord-007689-0vpp3xdl	340	4	,	,	,
cord-007689-0vpp3xdl	340	5	or	or	CC
cord-007689-0vpp3xdl	340	6	cellular	cellular	JJ
cord-007689-0vpp3xdl	340	7	parasites	parasite	NNS
cord-007689-0vpp3xdl	340	8	are	be	VBP
cord-007689-0vpp3xdl	340	9	recognized	recognize	VBN
cord-007689-0vpp3xdl	340	10	via	via	IN
cord-007689-0vpp3xdl	340	11	conserved	conserve	VBN
cord-007689-0vpp3xdl	340	12	molecules	molecule	NNS
cord-007689-0vpp3xdl	340	13	typical	typical	JJ
cord-007689-0vpp3xdl	340	14	for	for	IN
cord-007689-0vpp3xdl	340	15	the	the	DT
cord-007689-0vpp3xdl	340	16	respective	respective	JJ
cord-007689-0vpp3xdl	340	17	type	type	NN
cord-007689-0vpp3xdl	340	18	of	of	IN
cord-007689-0vpp3xdl	340	19	pathogen	pathogen	NN
cord-007689-0vpp3xdl	340	20	.	.	.
cord-007689-0vpp3xdl	341	1	In	in	IN
cord-007689-0vpp3xdl	341	2	contrast	contrast	NN
cord-007689-0vpp3xdl	341	3	,	,	,
cord-007689-0vpp3xdl	341	4	all	all	DT
cord-007689-0vpp3xdl	341	5	virus	virus	NN
cord-007689-0vpp3xdl	341	6	components	component	NNS
cord-007689-0vpp3xdl	341	7	are	be	VBP
cord-007689-0vpp3xdl	341	8	formed	form	VBN
cord-007689-0vpp3xdl	341	9	within	within	IN
cord-007689-0vpp3xdl	341	10	the	the	DT
cord-007689-0vpp3xdl	341	11	infected	infected	JJ
cord-007689-0vpp3xdl	341	12	host	host	NN
cord-007689-0vpp3xdl	341	13	cell	cell	NN
cord-007689-0vpp3xdl	341	14	;	;	:
cord-007689-0vpp3xdl	341	15	consequently	consequently	RB
cord-007689-0vpp3xdl	341	16	,	,	,
cord-007689-0vpp3xdl	341	17	a	a	DT
cord-007689-0vpp3xdl	341	18	virus	virus	NN
cord-007689-0vpp3xdl	341	19	-	-	HYPH
cord-007689-0vpp3xdl	341	20	specific	specific	JJ
cord-007689-0vpp3xdl	341	21	detection	detection	NN
cord-007689-0vpp3xdl	341	22	system	system	NN
cord-007689-0vpp3xdl	341	23	is	be	VBZ
cord-007689-0vpp3xdl	341	24	more	more	RBR
cord-007689-0vpp3xdl	341	25	difficult	difficult	JJ
cord-007689-0vpp3xdl	341	26	to	to	TO
cord-007689-0vpp3xdl	341	27	achieve	achieve	VB
cord-007689-0vpp3xdl	341	28	.	.	.
cord-007689-0vpp3xdl	342	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	342	2	is	be	VBZ
cord-007689-0vpp3xdl	342	3	now	now	RB
cord-007689-0vpp3xdl	342	4	evident	evident	JJ
cord-007689-0vpp3xdl	342	5	that	that	IN
cord-007689-0vpp3xdl	342	6	host	host	NN
cord-007689-0vpp3xdl	342	7	cells	cell	NNS
cord-007689-0vpp3xdl	342	8	are	be	VBP
cord-007689-0vpp3xdl	342	9	equipped	equip	VBN
cord-007689-0vpp3xdl	342	10	to	to	TO
cord-007689-0vpp3xdl	342	11	detect	detect	VB
cord-007689-0vpp3xdl	342	12	viral	viral	JJ
cord-007689-0vpp3xdl	342	13	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	342	14	acids	acid	NNS
cord-007689-0vpp3xdl	342	15	.	.	.
cord-007689-0vpp3xdl	343	1	For	for	IN
cord-007689-0vpp3xdl	343	2	viral	viral	JJ
cord-007689-0vpp3xdl	343	3	infection	infection	NN
cord-007689-0vpp3xdl	343	4	in	in	IN
cord-007689-0vpp3xdl	343	5	vivo	vivo	NN
cord-007689-0vpp3xdl	343	6	,	,	,
cord-007689-0vpp3xdl	343	7	the	the	DT
cord-007689-0vpp3xdl	343	8	following	follow	VBG
cord-007689-0vpp3xdl	343	9	picture	picture	NN
cord-007689-0vpp3xdl	343	10	is	be	VBZ
cord-007689-0vpp3xdl	343	11	evolving	evolve	VBG
cord-007689-0vpp3xdl	343	12	:	:	:
cord-007689-0vpp3xdl	343	13	large	large	JJ
cord-007689-0vpp3xdl	343	14	parts	part	NNS
cord-007689-0vpp3xdl	343	15	of	of	IN
cord-007689-0vpp3xdl	343	16	the	the	DT
cord-007689-0vpp3xdl	343	17	early	early	JJ
cord-007689-0vpp3xdl	343	18	type	type	NN
cord-007689-0vpp3xdl	344	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	344	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	344	3	response	response	NN
cord-007689-0vpp3xdl	344	4	upon	upon	IN
cord-007689-0vpp3xdl	344	5	viral	viral	JJ
cord-007689-0vpp3xdl	344	6	infection	infection	NN
cord-007689-0vpp3xdl	344	7	are	be	VBP
cord-007689-0vpp3xdl	344	8	due	due	JJ
cord-007689-0vpp3xdl	344	9	to	to	IN
cord-007689-0vpp3xdl	344	10	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	344	11	and	and	CC
cord-007689-0vpp3xdl	344	12	TLR9	TLR9	NNP
cord-007689-0vpp3xdl	344	13	expressed	express	VBD
cord-007689-0vpp3xdl	344	14	in	in	IN
cord-007689-0vpp3xdl	344	15	PDCs	pdc	NNS
cord-007689-0vpp3xdl	344	16	;	;	:
cord-007689-0vpp3xdl	344	17	in	in	IN
cord-007689-0vpp3xdl	344	18	fact	fact	NN
cord-007689-0vpp3xdl	344	19	,	,	,
cord-007689-0vpp3xdl	344	20	PDCs	pdc	NNS
cord-007689-0vpp3xdl	344	21	are	be	VBP
cord-007689-0vpp3xdl	344	22	the	the	DT
cord-007689-0vpp3xdl	344	23	only	only	JJ
cord-007689-0vpp3xdl	344	24	considerable	considerable	JJ
cord-007689-0vpp3xdl	344	25	source	source	NN
cord-007689-0vpp3xdl	344	26	of	of	IN
cord-007689-0vpp3xdl	344	27	TLR7-and	TLR7-and	NNP
cord-007689-0vpp3xdl	344	28	TLR9-induced	TLR9-induced	NNP
cord-007689-0vpp3xdl	344	29	type	type	NN
cord-007689-0vpp3xdl	345	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	345	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	345	3	production	production	NN
cord-007689-0vpp3xdl	345	4	upon	upon	IN
cord-007689-0vpp3xdl	345	5	viral	viral	JJ
cord-007689-0vpp3xdl	345	6	infection	infection	NN
cord-007689-0vpp3xdl	345	7	.	.	.
cord-007689-0vpp3xdl	346	1	The	the	DT
cord-007689-0vpp3xdl	346	2	major	major	JJ
cord-007689-0vpp3xdl	346	3	advantages	advantage	NNS
cord-007689-0vpp3xdl	346	4	of	of	IN
cord-007689-0vpp3xdl	346	5	this	this	DT
cord-007689-0vpp3xdl	346	6	PDC	PDC	NNP
cord-007689-0vpp3xdl	346	7	response	response	NN
cord-007689-0vpp3xdl	346	8	are	be	VBP
cord-007689-0vpp3xdl	346	9	that	that	IN
cord-007689-0vpp3xdl	346	10	the	the	DT
cord-007689-0vpp3xdl	346	11	presence	presence	NN
cord-007689-0vpp3xdl	346	12	of	of	IN
cord-007689-0vpp3xdl	346	13	viral	viral	JJ
cord-007689-0vpp3xdl	346	14	particles	particle	NNS
cord-007689-0vpp3xdl	346	15	is	be	VBZ
cord-007689-0vpp3xdl	346	16	sufficient	sufficient	JJ
cord-007689-0vpp3xdl	346	17	for	for	IN
cord-007689-0vpp3xdl	346	18	recognition	recognition	NN
cord-007689-0vpp3xdl	346	19	,	,	,
cord-007689-0vpp3xdl	346	20	that	that	IN
cord-007689-0vpp3xdl	346	21	viral	viral	JJ
cord-007689-0vpp3xdl	346	22	infection	infection	NN
cord-007689-0vpp3xdl	346	23	of	of	IN
cord-007689-0vpp3xdl	346	24	cells	cell	NNS
cord-007689-0vpp3xdl	346	25	is	be	VBZ
cord-007689-0vpp3xdl	346	26	not	not	RB
cord-007689-0vpp3xdl	346	27	required	require	VBN
cord-007689-0vpp3xdl	346	28	for	for	IN
cord-007689-0vpp3xdl	346	29	detection	detection	NN
cord-007689-0vpp3xdl	346	30	,	,	,
cord-007689-0vpp3xdl	346	31	and	and	CC
cord-007689-0vpp3xdl	346	32	that	that	IN
cord-007689-0vpp3xdl	346	33	viruses	virus	NNS
cord-007689-0vpp3xdl	346	34	are	be	VBP
cord-007689-0vpp3xdl	346	35	recognized	recognize	VBN
cord-007689-0vpp3xdl	346	36	before	before	IN
cord-007689-0vpp3xdl	346	37	viral	viral	JJ
cord-007689-0vpp3xdl	346	38	proteins	protein	NNS
cord-007689-0vpp3xdl	346	39	have	have	VBP
cord-007689-0vpp3xdl	346	40	a	a	DT
cord-007689-0vpp3xdl	346	41	chance	chance	NN
cord-007689-0vpp3xdl	346	42	to	to	TO
cord-007689-0vpp3xdl	346	43	mediate	mediate	VB
cord-007689-0vpp3xdl	346	44	immune	immune	JJ
cord-007689-0vpp3xdl	346	45	evasion	evasion	NN
cord-007689-0vpp3xdl	346	46	.	.	.
cord-007689-0vpp3xdl	347	1	This	this	DT
cord-007689-0vpp3xdl	347	2	first	first	JJ
cord-007689-0vpp3xdl	347	3	wave	wave	NN
cord-007689-0vpp3xdl	347	4	of	of	IN
cord-007689-0vpp3xdl	347	5	type	type	NN
cord-007689-0vpp3xdl	347	6	I	-PRON-	PRP
cord-007689-0vpp3xdl	347	7	IFN	IFN	NNP
cord-007689-0vpp3xdl	347	8	production	production	NN
cord-007689-0vpp3xdl	347	9	plays	play	VBZ
cord-007689-0vpp3xdl	347	10	an	an	DT
cord-007689-0vpp3xdl	347	11	important	important	JJ
cord-007689-0vpp3xdl	347	12	role	role	NN
cord-007689-0vpp3xdl	347	13	in	in	IN
cord-007689-0vpp3xdl	347	14	limiting	limit	VBG
cord-007689-0vpp3xdl	347	15	viral	viral	JJ
cord-007689-0vpp3xdl	347	16	spread	spread	NN
cord-007689-0vpp3xdl	347	17	by	by	IN
cord-007689-0vpp3xdl	347	18	PDC	PDC	NNP
cord-007689-0vpp3xdl	347	19	-	-	HYPH
cord-007689-0vpp3xdl	347	20	derived	derive	VBN
cord-007689-0vpp3xdl	347	21	direct	direct	JJ
cord-007689-0vpp3xdl	347	22	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	347	23	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	347	24	early	early	RB
cord-007689-0vpp3xdl	347	25	on	on	RB
cord-007689-0vpp3xdl	347	26	,	,	,
cord-007689-0vpp3xdl	347	27	and	and	CC
cord-007689-0vpp3xdl	347	28	by	by	IN
cord-007689-0vpp3xdl	347	29	sensitizing	sensitize	VBG
cord-007689-0vpp3xdl	347	30	yet	yet	CC
cord-007689-0vpp3xdl	347	31	uninfected	uninfected	JJ
cord-007689-0vpp3xdl	347	32	cells	cell	NNS
cord-007689-0vpp3xdl	347	33	for	for	IN
cord-007689-0vpp3xdl	347	34	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	347	35	recognition	recognition	NN
cord-007689-0vpp3xdl	347	36	of	of	IN
cord-007689-0vpp3xdl	347	37	viral	viral	JJ
cord-007689-0vpp3xdl	347	38	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	347	39	acid	acid	NN
cord-007689-0vpp3xdl	347	40	via	via	IN
cord-007689-0vpp3xdl	347	41	strong	strong	JJ
cord-007689-0vpp3xdl	347	42	upregulation	upregulation	NN
cord-007689-0vpp3xdl	347	43	of	of	IN
cord-007689-0vpp3xdl	347	44	the	the	DT
cord-007689-0vpp3xdl	347	45	two	two	CD
cord-007689-0vpp3xdl	347	46	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	347	47	helicases	helicase	NNS
cord-007689-0vpp3xdl	347	48	,	,	,
cord-007689-0vpp3xdl	347	49	RIG	rig	NN
cord-007689-0vpp3xdl	347	50	-	-	:
cord-007689-0vpp3xdl	347	51	I	-PRON-	PRP
cord-007689-0vpp3xdl	347	52	and	and	CC
cord-007689-0vpp3xdl	347	53	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	347	54	.	.	.
cord-007689-0vpp3xdl	348	1	These	these	DT
cord-007689-0vpp3xdl	348	2	two	two	CD
cord-007689-0vpp3xdl	348	3	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	348	4	receptors	receptor	NNS
cord-007689-0vpp3xdl	348	5	are	be	VBP
cord-007689-0vpp3xdl	348	6	then	then	RB
cord-007689-0vpp3xdl	348	7	responsible	responsible	JJ
cord-007689-0vpp3xdl	348	8	for	for	IN
cord-007689-0vpp3xdl	348	9	the	the	DT
cord-007689-0vpp3xdl	348	10	second	second	JJ
cord-007689-0vpp3xdl	348	11	and	and	CC
cord-007689-0vpp3xdl	348	12	prolonged	prolonged	JJ
cord-007689-0vpp3xdl	348	13	wave	wave	NN
cord-007689-0vpp3xdl	348	14	of	of	IN
cord-007689-0vpp3xdl	348	15	type	type	NN
cord-007689-0vpp3xdl	348	16	I	-PRON-	PRP
cord-007689-0vpp3xdl	348	17	IFN	IFN	NNP
cord-007689-0vpp3xdl	348	18	production	production	NN
cord-007689-0vpp3xdl	348	19	and	and	CC
cord-007689-0vpp3xdl	348	20	for	for	IN
cord-007689-0vpp3xdl	348	21	the	the	DT
cord-007689-0vpp3xdl	348	22	induction	induction	NN
cord-007689-0vpp3xdl	348	23	of	of	IN
cord-007689-0vpp3xdl	348	24	apoptosis	apoptosis	NN
cord-007689-0vpp3xdl	348	25	of	of	IN
cord-007689-0vpp3xdl	348	26	virally	virally	RB
cord-007689-0vpp3xdl	348	27	infected	infect	VBN
cord-007689-0vpp3xdl	348	28	cells	cell	NNS
cord-007689-0vpp3xdl	348	29	.	.	.
cord-007689-0vpp3xdl	349	1	For	for	IN
cord-007689-0vpp3xdl	349	2	all	all	DT
cord-007689-0vpp3xdl	349	3	four	four	CD
cord-007689-0vpp3xdl	349	4	receptors	receptor	NNS
cord-007689-0vpp3xdl	349	5	,	,	,
cord-007689-0vpp3xdl	349	6	distinction	distinction	NN
cord-007689-0vpp3xdl	349	7	of	of	IN
cord-007689-0vpp3xdl	349	8	self	self	NN
cord-007689-0vpp3xdl	349	9	from	from	IN
cord-007689-0vpp3xdl	349	10	viral	viral	JJ
cord-007689-0vpp3xdl	349	11	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	349	12	acid	acid	NN
cord-007689-0vpp3xdl	349	13	is	be	VBZ
cord-007689-0vpp3xdl	349	14	based	base	VBN
cord-007689-0vpp3xdl	349	15	on	on	IN
cord-007689-0vpp3xdl	349	16	a	a	DT
cord-007689-0vpp3xdl	349	17	combination	combination	NN
cord-007689-0vpp3xdl	349	18	of	of	IN
cord-007689-0vpp3xdl	349	19	localization	localization	NN
cord-007689-0vpp3xdl	349	20	and	and	CC
cord-007689-0vpp3xdl	349	21	molecular	molecular	JJ
cord-007689-0vpp3xdl	349	22	structure	structure	NN
cord-007689-0vpp3xdl	349	23	.	.	.
cord-007689-0vpp3xdl	350	1	In	in	IN
cord-007689-0vpp3xdl	350	2	this	this	DT
cord-007689-0vpp3xdl	350	3	sophisticated	sophisticated	JJ
cord-007689-0vpp3xdl	350	4	system	system	NN
cord-007689-0vpp3xdl	350	5	of	of	IN
cord-007689-0vpp3xdl	350	6	virus	virus	NN
cord-007689-0vpp3xdl	350	7	detection	detection	NN
cord-007689-0vpp3xdl	350	8	,	,	,
cord-007689-0vpp3xdl	350	9	the	the	DT
cord-007689-0vpp3xdl	350	10	following	follow	VBG
cord-007689-0vpp3xdl	350	11	situations	situation	NNS
cord-007689-0vpp3xdl	350	12	signal	signal	VBP
cord-007689-0vpp3xdl	350	13	viral	viral	JJ
cord-007689-0vpp3xdl	350	14	danger	danger	NN
cord-007689-0vpp3xdl	350	15	:	:	:
cord-007689-0vpp3xdl	351	1	1	1	LS
cord-007689-0vpp3xdl	351	2	.	.	.
cord-007689-0vpp3xdl	352	1	Appearance	appearance	NN
cord-007689-0vpp3xdl	352	2	of	of	IN
cord-007689-0vpp3xdl	352	3	unmodified	unmodified	JJ
cord-007689-0vpp3xdl	352	4	RNA	RNA	NNP
cord-007689-0vpp3xdl	352	5	in	in	IN
cord-007689-0vpp3xdl	352	6	the	the	DT
cord-007689-0vpp3xdl	352	7	endosomal	endosomal	NNP
cord-007689-0vpp3xdl	352	8	compartment	compartment	NN
cord-007689-0vpp3xdl	352	9	of	of	IN
cord-007689-0vpp3xdl	352	10	PDCs	PDCs	NNP
cord-007689-0vpp3xdl	352	11	2	2	CD
cord-007689-0vpp3xdl	352	12	.	.	.
cord-007689-0vpp3xdl	353	1	Appearance	appearance	NN
cord-007689-0vpp3xdl	353	2	of	of	IN
cord-007689-0vpp3xdl	353	3	DNA	DNA	NNP
cord-007689-0vpp3xdl	353	4	containing	contain	VBG
cord-007689-0vpp3xdl	353	5	unmethylated	unmethylate	VBN
cord-007689-0vpp3xdl	353	6	CpG	CpG	NNP
cord-007689-0vpp3xdl	353	7	motifs	motif	NNS
cord-007689-0vpp3xdl	353	8	in	in	IN
cord-007689-0vpp3xdl	353	9	the	the	DT
cord-007689-0vpp3xdl	353	10	endosomal	endosomal	NNP
cord-007689-0vpp3xdl	353	11	compartment	compartment	NN
cord-007689-0vpp3xdl	353	12	of	of	IN
cord-007689-0vpp3xdl	353	13	PDCs	PDCs	NNP
cord-007689-0vpp3xdl	353	14	3	3	CD
cord-007689-0vpp3xdl	353	15	.	.	.
cord-007689-0vpp3xdl	354	1	Unmodified	Unmodified	NNP
cord-007689-0vpp3xdl	354	2	RNA	RNA	NNP
cord-007689-0vpp3xdl	354	3	with	with	IN
cord-007689-0vpp3xdl	354	4	a	a	DT
cord-007689-0vpp3xdl	354	5	triphosphate	triphosphate	NN
cord-007689-0vpp3xdl	354	6	group	group	NN
cord-007689-0vpp3xdl	354	7	at	at	IN
cord-007689-0vpp3xdl	354	8	the	the	DT
cord-007689-0vpp3xdl	354	9	5′	5′	CD
cord-007689-0vpp3xdl	354	10	end	end	NN
cord-007689-0vpp3xdl	354	11	(	(	-LRB-
cord-007689-0vpp3xdl	354	12	3pRNA	3prna	CD
cord-007689-0vpp3xdl	354	13	)	)	-RRB-
cord-007689-0vpp3xdl	354	14	in	in	IN
cord-007689-0vpp3xdl	354	15	the	the	DT
cord-007689-0vpp3xdl	354	16	cytosol	cytosol	NN
cord-007689-0vpp3xdl	354	17	of	of	IN
cord-007689-0vpp3xdl	354	18	any	any	DT
cord-007689-0vpp3xdl	354	19	cell	cell	NN
cord-007689-0vpp3xdl	354	20	type	type	NN
cord-007689-0vpp3xdl	354	21	4	4	CD
cord-007689-0vpp3xdl	354	22	.	.	.
cord-007689-0vpp3xdl	355	1	DNA	DNA	NNP
cord-007689-0vpp3xdl	355	2	in	in	IN
cord-007689-0vpp3xdl	355	3	the	the	DT
cord-007689-0vpp3xdl	355	4	cytosol	cytosol	NN
cord-007689-0vpp3xdl	355	5	of	of	IN
cord-007689-0vpp3xdl	355	6	any	any	DT
cord-007689-0vpp3xdl	355	7	cell	cell	NN
cord-007689-0vpp3xdl	355	8	type	type	NN
cord-007689-0vpp3xdl	356	1	It	-PRON-	PRP
cord-007689-0vpp3xdl	356	2	is	be	VBZ
cord-007689-0vpp3xdl	356	3	still	still	RB
cord-007689-0vpp3xdl	356	4	unclear	unclear	JJ
cord-007689-0vpp3xdl	356	5	whether	whether	IN
cord-007689-0vpp3xdl	356	6	long	long	JJ
cord-007689-0vpp3xdl	356	7	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	356	8	in	in	IN
cord-007689-0vpp3xdl	356	9	the	the	DT
cord-007689-0vpp3xdl	356	10	cytosol	cytosol	NN
cord-007689-0vpp3xdl	356	11	is	be	VBZ
cord-007689-0vpp3xdl	356	12	sufficient	sufficient	JJ
cord-007689-0vpp3xdl	356	13	to	to	TO
cord-007689-0vpp3xdl	356	14	elicit	elicit	VB
cord-007689-0vpp3xdl	356	15	an	an	DT
cord-007689-0vpp3xdl	356	16	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	356	17	response	response	NN
cord-007689-0vpp3xdl	356	18	via	via	IN
cord-007689-0vpp3xdl	356	19	one	one	CD
cord-007689-0vpp3xdl	356	20	of	of	IN
cord-007689-0vpp3xdl	356	21	the	the	DT
cord-007689-0vpp3xdl	356	22	receptors	receptor	NNS
cord-007689-0vpp3xdl	356	23	known	know	VBN
cord-007689-0vpp3xdl	356	24	to	to	IN
cord-007689-0vpp3xdl	356	25	date	date	NN
cord-007689-0vpp3xdl	356	26	.	.	.
cord-007689-0vpp3xdl	357	1	Although	although	IN
cord-007689-0vpp3xdl	357	2	poly	poly	NNP
cord-007689-0vpp3xdl	357	3	I	i	NN
cord-007689-0vpp3xdl	357	4	:	:	:
cord-007689-0vpp3xdl	357	5	C	C	NNP
cord-007689-0vpp3xdl	357	6	is	be	VBZ
cord-007689-0vpp3xdl	357	7	a	a	DT
cord-007689-0vpp3xdl	357	8	ligand	ligand	NN
cord-007689-0vpp3xdl	357	9	for	for	IN
cord-007689-0vpp3xdl	357	10	MDA-5	MDA-5	NNP
cord-007689-0vpp3xdl	358	1	,	,	,
cord-007689-0vpp3xdl	358	2	long	long	RB
cord-007689-0vpp3xdl	358	3	double	double	RB
cord-007689-0vpp3xdl	358	4	-	-	HYPH
cord-007689-0vpp3xdl	358	5	stranded	strand	VBN
cord-007689-0vpp3xdl	358	6	RNA	RNA	NNP
cord-007689-0vpp3xdl	358	7	seems	seem	VBZ
cord-007689-0vpp3xdl	358	8	insufficient	insufficient	JJ
cord-007689-0vpp3xdl	358	9	as	as	IN
cord-007689-0vpp3xdl	358	10	a	a	DT
cord-007689-0vpp3xdl	358	11	ligand	ligand	NN
cord-007689-0vpp3xdl	358	12	,	,	,
cord-007689-0vpp3xdl	358	13	and	and	CC
cord-007689-0vpp3xdl	358	14	the	the	DT
cord-007689-0vpp3xdl	358	15	natural	natural	JJ
cord-007689-0vpp3xdl	358	16	ligand	ligand	NN
cord-007689-0vpp3xdl	358	17	still	still	RB
cord-007689-0vpp3xdl	358	18	needs	need	VBZ
cord-007689-0vpp3xdl	358	19	to	to	TO
cord-007689-0vpp3xdl	358	20	be	be	VB
cord-007689-0vpp3xdl	358	21	identified	identify	VBN
cord-007689-0vpp3xdl	358	22	.	.	.
cord-007689-0vpp3xdl	359	1	In	in	IN
cord-007689-0vpp3xdl	359	2	addition	addition	NN
cord-007689-0vpp3xdl	359	3	to	to	IN
cord-007689-0vpp3xdl	359	4	RNAdetecting	rnadetecte	VBG
cord-007689-0vpp3xdl	359	5	receptors	receptor	NNS
cord-007689-0vpp3xdl	359	6	,	,	,
cord-007689-0vpp3xdl	359	7	the	the	DT
cord-007689-0vpp3xdl	359	8	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	359	9	receptor	receptor	NN
cord-007689-0vpp3xdl	359	10	for	for	IN
cord-007689-0vpp3xdl	359	11	DNA	DNA	NNP
cord-007689-0vpp3xdl	359	12	may	may	MD
cord-007689-0vpp3xdl	359	13	add	add	VB
cord-007689-0vpp3xdl	359	14	new	new	JJ
cord-007689-0vpp3xdl	359	15	perspectives	perspective	NNS
cord-007689-0vpp3xdl	359	16	in	in	IN
cord-007689-0vpp3xdl	359	17	therapeutic	therapeutic	JJ
cord-007689-0vpp3xdl	359	18	viral	viral	JJ
cord-007689-0vpp3xdl	359	19	mimicry	mimicry	NN
cord-007689-0vpp3xdl	359	20	.	.	.
cord-007689-0vpp3xdl	360	1	With	with	IN
cord-007689-0vpp3xdl	360	2	regard	regard	NN
cord-007689-0vpp3xdl	360	3	to	to	IN
cord-007689-0vpp3xdl	360	4	viruses	virus	NNS
cord-007689-0vpp3xdl	360	5	that	that	WDT
cord-007689-0vpp3xdl	360	6	perform	perform	VBP
cord-007689-0vpp3xdl	360	7	inside	inside	IN
cord-007689-0vpp3xdl	360	8	the	the	DT
cord-007689-0vpp3xdl	360	9	nucleus	nucleus	NN
cord-007689-0vpp3xdl	360	10	such	such	JJ
cord-007689-0vpp3xdl	360	11	as	as	IN
cord-007689-0vpp3xdl	360	12	HBV	HBV	NNP
cord-007689-0vpp3xdl	360	13	and	and	CC
cord-007689-0vpp3xdl	360	14	HIV	HIV	NNP
cord-007689-0vpp3xdl	360	15	,	,	,
cord-007689-0vpp3xdl	360	16	uncovering	uncover	VBG
cord-007689-0vpp3xdl	360	17	molecular	molecular	JJ
cord-007689-0vpp3xdl	360	18	mechanisms	mechanism	NNS
cord-007689-0vpp3xdl	360	19	of	of	IN
cord-007689-0vpp3xdl	360	20	sensing	sense	VBG
cord-007689-0vpp3xdl	360	21	viral	viral	JJ
cord-007689-0vpp3xdl	360	22	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	360	23	acids	acid	NNS
cord-007689-0vpp3xdl	360	24	in	in	IN
cord-007689-0vpp3xdl	360	25	the	the	DT
cord-007689-0vpp3xdl	360	26	nucleus	nucleus	NN
cord-007689-0vpp3xdl	360	27	appears	appear	VBZ
cord-007689-0vpp3xdl	360	28	on	on	IN
cord-007689-0vpp3xdl	360	29	the	the	DT
cord-007689-0vpp3xdl	360	30	radar	radar	NN
cord-007689-0vpp3xdl	360	31	of	of	IN
cord-007689-0vpp3xdl	360	32	scientific	scientific	JJ
cord-007689-0vpp3xdl	360	33	challenges	challenge	NNS
cord-007689-0vpp3xdl	360	34	.	.	.
cord-007689-0vpp3xdl	361	1	Recognition	recognition	NN
cord-007689-0vpp3xdl	361	2	of	of	IN
cord-007689-0vpp3xdl	361	3	double	double	RB
cord-007689-0vpp3xdl	361	4	-	-	HYPH
cord-007689-0vpp3xdl	361	5	stranded	strand	VBN
cord-007689-0vpp3xdl	361	6	RNA	RNA	NNP
cord-007689-0vpp3xdl	361	7	and	and	CC
cord-007689-0vpp3xdl	361	8	activation	activation	NN
cord-007689-0vpp3xdl	361	9	of	of	IN
cord-007689-0vpp3xdl	361	10	NF	NF	NNP
cord-007689-0vpp3xdl	361	11	-	-	HYPH
cord-007689-0vpp3xdl	361	12	kappaB	kappaB	NNP
cord-007689-0vpp3xdl	361	13	by	by	IN
cord-007689-0vpp3xdl	361	14	Toll	Toll	NNP
cord-007689-0vpp3xdl	361	15	-	-	HYPH
cord-007689-0vpp3xdl	361	16	like	like	JJ
cord-007689-0vpp3xdl	361	17	receptor	receptor	NN
cord-007689-0vpp3xdl	361	18	3	3	CD
cord-007689-0vpp3xdl	361	19	Cationic	Cationic	NNP
cord-007689-0vpp3xdl	361	20	liposome	liposome	NN
cord-007689-0vpp3xdl	361	21	-	-	HYPH
cord-007689-0vpp3xdl	361	22	mediated	mediate	VBN
cord-007689-0vpp3xdl	361	23	gene	gene	NN
cord-007689-0vpp3xdl	361	24	delivery	delivery	NN
cord-007689-0vpp3xdl	361	25	:	:	:
cord-007689-0vpp3xdl	361	26	biophysical	biophysical	JJ
cord-007689-0vpp3xdl	361	27	study	study	NN
cord-007689-0vpp3xdl	361	28	and	and	CC
cord-007689-0vpp3xdl	361	29	mechanism	mechanism	NN
cord-007689-0vpp3xdl	361	30	of	of	IN
cord-007689-0vpp3xdl	361	31	internalization	internalization	NN
cord-007689-0vpp3xdl	362	1	The	the	DT
cord-007689-0vpp3xdl	362	2	V	v	NN
cord-007689-0vpp3xdl	362	3	proteins	protein	NNS
cord-007689-0vpp3xdl	362	4	of	of	IN
cord-007689-0vpp3xdl	362	5	paramyxoviruses	paramyxovirus	NNS
cord-007689-0vpp3xdl	362	6	bind	bind	VBP
cord-007689-0vpp3xdl	362	7	the	the	DT
cord-007689-0vpp3xdl	362	8	IFN	IFN	NNP
cord-007689-0vpp3xdl	362	9	-	-	HYPH
cord-007689-0vpp3xdl	362	10	inducible	inducible	JJ
cord-007689-0vpp3xdl	362	11	RNA	RNA	NNP
cord-007689-0vpp3xdl	362	12	helicase	helicase	NN
cord-007689-0vpp3xdl	362	13	,	,	,
cord-007689-0vpp3xdl	362	14	mda-5	mda-5	NNP
cord-007689-0vpp3xdl	362	15	,	,	,
cord-007689-0vpp3xdl	362	16	and	and	CC
cord-007689-0vpp3xdl	362	17	inhibit	inhibit	VB
cord-007689-0vpp3xdl	362	18	its	-PRON-	PRP$
cord-007689-0vpp3xdl	362	19	activation	activation	NN
cord-007689-0vpp3xdl	362	20	of	of	IN
cord-007689-0vpp3xdl	362	21	the	the	DT
cord-007689-0vpp3xdl	362	22	IFN	IFN	NNP
cord-007689-0vpp3xdl	362	23	-	-	HYPH
cord-007689-0vpp3xdl	362	24	beta	beta	NN
cord-007689-0vpp3xdl	362	25	promoter	promoter	NN
cord-007689-0vpp3xdl	362	26	Virus	virus	NN
cord-007689-0vpp3xdl	362	27	-	-	HYPH
cord-007689-0vpp3xdl	362	28	specific	specific	JJ
cord-007689-0vpp3xdl	362	29	double	double	RB
cord-007689-0vpp3xdl	362	30	-	-	HYPH
cord-007689-0vpp3xdl	362	31	stranded	strand	VBN
cord-007689-0vpp3xdl	362	32	RNA	RNA	NNP
cord-007689-0vpp3xdl	362	33	in	in	IN
cord-007689-0vpp3xdl	362	34	poliovirus	poliovirus	NN
cord-007689-0vpp3xdl	362	35	-	-	HYPH
cord-007689-0vpp3xdl	362	36	infected	infect	VBN
cord-007689-0vpp3xdl	362	37	cells	cell	NNS
cord-007689-0vpp3xdl	363	1	Dendritic	dendritic	JJ
cord-007689-0vpp3xdl	363	2	cells	cell	NNS
cord-007689-0vpp3xdl	363	3	respond	respond	VBP
cord-007689-0vpp3xdl	363	4	to	to	IN
cord-007689-0vpp3xdl	363	5	influenza	influenza	NN
cord-007689-0vpp3xdl	363	6	virus	virus	NN
cord-007689-0vpp3xdl	363	7	through	through	IN
cord-007689-0vpp3xdl	363	8	TLR7-and	TLR7-and	NNP
cord-007689-0vpp3xdl	363	9	PKRindependent	PKRindependent	NNP
cord-007689-0vpp3xdl	363	10	pathways	pathway	NNS
cord-007689-0vpp3xdl	364	1	A	a	DT
cord-007689-0vpp3xdl	364	2	versatile	versatile	JJ
cord-007689-0vpp3xdl	364	3	vector	vector	NN
cord-007689-0vpp3xdl	364	4	for	for	IN
cord-007689-0vpp3xdl	364	5	gene	gene	NN
cord-007689-0vpp3xdl	364	6	and	and	CC
cord-007689-0vpp3xdl	364	7	oligonucleotide	oligonucleotide	JJ
cord-007689-0vpp3xdl	364	8	transfer	transfer	NN
cord-007689-0vpp3xdl	364	9	into	into	IN
cord-007689-0vpp3xdl	364	10	cells	cell	NNS
cord-007689-0vpp3xdl	364	11	in	in	IN
cord-007689-0vpp3xdl	364	12	culture	culture	NN
cord-007689-0vpp3xdl	364	13	and	and	CC
cord-007689-0vpp3xdl	364	14	in	in	IN
cord-007689-0vpp3xdl	364	15	vivo	vivo	NN
cord-007689-0vpp3xdl	364	16	:	:	:
cord-007689-0vpp3xdl	365	1	polyethylenimine	polyethylenimine	NNP
cord-007689-0vpp3xdl	365	2	Induction	Induction	NNP
cord-007689-0vpp3xdl	365	3	of	of	IN
cord-007689-0vpp3xdl	365	4	an	an	DT
cord-007689-0vpp3xdl	365	5	interferon	interferon	NN
cord-007689-0vpp3xdl	365	6	response	response	NN
cord-007689-0vpp3xdl	365	7	by	by	IN
cord-007689-0vpp3xdl	365	8	RNAi	RNAi	NNP
cord-007689-0vpp3xdl	365	9	vectors	vector	NNS
cord-007689-0vpp3xdl	365	10	in	in	IN
cord-007689-0vpp3xdl	365	11	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	365	12	cells	cell	NNS
cord-007689-0vpp3xdl	365	13	A	a	DT
cord-007689-0vpp3xdl	365	14	system	system	NN
cord-007689-0vpp3xdl	365	15	for	for	IN
cord-007689-0vpp3xdl	365	16	stable	stable	JJ
cord-007689-0vpp3xdl	365	17	expression	expression	NN
cord-007689-0vpp3xdl	365	18	of	of	IN
cord-007689-0vpp3xdl	365	19	short	short	JJ
cord-007689-0vpp3xdl	365	20	interfering	interfere	VBG
cord-007689-0vpp3xdl	365	21	RNAs	rna	NNS
cord-007689-0vpp3xdl	365	22	in	in	IN
cord-007689-0vpp3xdl	365	23	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	365	24	cells	cell	NNS
cord-007689-0vpp3xdl	365	25	Control	Control	NNP
cord-007689-0vpp3xdl	365	26	of	of	IN
cord-007689-0vpp3xdl	365	27	coronavirus	coronavirus	NN
cord-007689-0vpp3xdl	365	28	infection	infection	NN
cord-007689-0vpp3xdl	365	29	through	through	IN
cord-007689-0vpp3xdl	365	30	plasmacytoid	plasmacytoid	JJ
cord-007689-0vpp3xdl	365	31	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	365	32	-	-	HYPH
cord-007689-0vpp3xdl	365	33	cell	cell	NN
cord-007689-0vpp3xdl	365	34	-	-	HYPH
cord-007689-0vpp3xdl	365	35	derived	derive	VBN
cord-007689-0vpp3xdl	365	36	type	type	NN
cord-007689-0vpp3xdl	366	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	366	2	interferon	interferon	VBD
cord-007689-0vpp3xdl	366	3	JNK2	JNK2	NNP
cord-007689-0vpp3xdl	366	4	and	and	CC
cord-007689-0vpp3xdl	366	5	IKKbeta	IKKbeta	NNP
cord-007689-0vpp3xdl	366	6	are	be	VBP
cord-007689-0vpp3xdl	366	7	required	require	VBN
cord-007689-0vpp3xdl	366	8	for	for	IN
cord-007689-0vpp3xdl	366	9	activating	activate	VBG
cord-007689-0vpp3xdl	366	10	the	the	DT
cord-007689-0vpp3xdl	366	11	innate	innate	JJ
cord-007689-0vpp3xdl	366	12	response	response	NN
cord-007689-0vpp3xdl	366	13	to	to	IN
cord-007689-0vpp3xdl	366	14	viral	viral	JJ
cord-007689-0vpp3xdl	366	15	infection	infection	NN
cord-007689-0vpp3xdl	366	16	Plasmacytoid	Plasmacytoid	NNP
cord-007689-0vpp3xdl	366	17	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	366	18	cells	cell	NNS
cord-007689-0vpp3xdl	366	19	in	in	IN
cord-007689-0vpp3xdl	366	20	immunity	immunity	NN
cord-007689-0vpp3xdl	366	21	Complete	complete	JJ
cord-007689-0vpp3xdl	366	22	nucleotide	nucleotide	JJ
cord-007689-0vpp3xdl	366	23	sequence	sequence	NN
cord-007689-0vpp3xdl	366	24	of	of	IN
cord-007689-0vpp3xdl	366	25	the	the	DT
cord-007689-0vpp3xdl	366	26	leader	leader	NN
cord-007689-0vpp3xdl	366	27	RNA	RNA	NNP
cord-007689-0vpp3xdl	366	28	synthesized	synthesize	VBN
cord-007689-0vpp3xdl	366	29	in	in	IN
cord-007689-0vpp3xdl	366	30	vitro	vitro	FW
cord-007689-0vpp3xdl	366	31	by	by	IN
cord-007689-0vpp3xdl	366	32	vesicular	vesicular	JJ
cord-007689-0vpp3xdl	366	33	stomatitis	stomatitis	NN
cord-007689-0vpp3xdl	366	34	virus	virus	NN
cord-007689-0vpp3xdl	366	35	RNA	RNA	NNP
cord-007689-0vpp3xdl	366	36	-	-	HYPH
cord-007689-0vpp3xdl	366	37	guided	guide	VBN
cord-007689-0vpp3xdl	366	38	nucleotide	nucleotide	JJ
cord-007689-0vpp3xdl	366	39	modification	modification	NN
cord-007689-0vpp3xdl	366	40	of	of	IN
cord-007689-0vpp3xdl	366	41	ribosomal	ribosomal	JJ
cord-007689-0vpp3xdl	366	42	and	and	CC
cord-007689-0vpp3xdl	366	43	other	other	JJ
cord-007689-0vpp3xdl	366	44	RNAs	rna	NNS
cord-007689-0vpp3xdl	367	1	Innate	innate	JJ
cord-007689-0vpp3xdl	367	2	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	367	3	responses	response	NNS
cord-007689-0vpp3xdl	367	4	by	by	IN
cord-007689-0vpp3xdl	367	5	means	mean	NNS
cord-007689-0vpp3xdl	367	6	of	of	IN
cord-007689-0vpp3xdl	367	7	TLR7-mediated	tlr7-mediated	JJ
cord-007689-0vpp3xdl	367	8	recognition	recognition	NN
cord-007689-0vpp3xdl	367	9	of	of	IN
cord-007689-0vpp3xdl	367	10	single	single	RB
cord-007689-0vpp3xdl	367	11	-	-	HYPH
cord-007689-0vpp3xdl	367	12	stranded	strand	VBN
cord-007689-0vpp3xdl	367	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	367	14	Viral	viral	JJ
cord-007689-0vpp3xdl	367	15	infection	infection	NN
cord-007689-0vpp3xdl	367	16	switches	switch	VBZ
cord-007689-0vpp3xdl	367	17	non	non	JJ
cord-007689-0vpp3xdl	367	18	-	-	JJ
cord-007689-0vpp3xdl	367	19	plasmacytoid	plasmacytoid	JJ
cord-007689-0vpp3xdl	367	20	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	367	21	cells	cell	NNS
cord-007689-0vpp3xdl	367	22	into	into	IN
cord-007689-0vpp3xdl	367	23	high	high	JJ
cord-007689-0vpp3xdl	367	24	interferon	interferon	NN
cord-007689-0vpp3xdl	367	25	producers	producer	NNS
cord-007689-0vpp3xdl	368	1	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	368	2	mediates	mediate	VBZ
cord-007689-0vpp3xdl	369	1	a	a	DT
cord-007689-0vpp3xdl	369	2	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	369	3	/	/	SYM
cord-007689-0vpp3xdl	369	4	TLR4-specific	TLR4-specific	NNP
cord-007689-0vpp3xdl	369	5	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	369	6	gene	gene	NN
cord-007689-0vpp3xdl	369	7	program	program	NN
cord-007689-0vpp3xdl	369	8	Duplexes	Duplexes	NNPS
cord-007689-0vpp3xdl	369	9	of	of	IN
cord-007689-0vpp3xdl	369	10	21-nucleotide	21-nucleotide	CD
cord-007689-0vpp3xdl	369	11	RNAs	rna	NNS
cord-007689-0vpp3xdl	369	12	mediate	mediate	VBP
cord-007689-0vpp3xdl	369	13	RNA	RNA	NNP
cord-007689-0vpp3xdl	369	14	interference	interference	NN
cord-007689-0vpp3xdl	369	15	in	in	IN
cord-007689-0vpp3xdl	369	16	cultured	cultured	JJ
cord-007689-0vpp3xdl	369	17	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	369	18	cells	cell	NNS
cord-007689-0vpp3xdl	370	1	Interferon	interferon	NN
cord-007689-0vpp3xdl	370	2	-	-	HYPH
cord-007689-0vpp3xdl	370	3	beta	beta	NN
cord-007689-0vpp3xdl	370	4	is	be	VBZ
cord-007689-0vpp3xdl	370	5	required	require	VBN
cord-007689-0vpp3xdl	370	6	for	for	IN
cord-007689-0vpp3xdl	370	7	interferon	interferon	NN
cord-007689-0vpp3xdl	370	8	-	-	HYPH
cord-007689-0vpp3xdl	370	9	alpha	alpha	NN
cord-007689-0vpp3xdl	370	10	production	production	NN
cord-007689-0vpp3xdl	370	11	in	in	IN
cord-007689-0vpp3xdl	370	12	mouse	mouse	NN
cord-007689-0vpp3xdl	370	13	fibroblasts	fibroblast	NNS
cord-007689-0vpp3xdl	371	1	Interferon	interferon	NN
cord-007689-0vpp3xdl	371	2	action	action	NN
cord-007689-0vpp3xdl	371	3	:	:	:
cord-007689-0vpp3xdl	371	4	two	two	CD
cord-007689-0vpp3xdl	371	5	distinct	distinct	JJ
cord-007689-0vpp3xdl	371	6	pathways	pathway	NNS
cord-007689-0vpp3xdl	371	7	for	for	IN
cord-007689-0vpp3xdl	371	8	inhibition	inhibition	NN
cord-007689-0vpp3xdl	371	9	of	of	IN
cord-007689-0vpp3xdl	371	10	protein	protein	NN
cord-007689-0vpp3xdl	371	11	synthesis	synthesis	NN
cord-007689-0vpp3xdl	371	12	by	by	IN
cord-007689-0vpp3xdl	371	13	double	double	RB
cord-007689-0vpp3xdl	371	14	-	-	HYPH
cord-007689-0vpp3xdl	371	15	stranded	strand	VBN
cord-007689-0vpp3xdl	371	16	RNA	RNA	NNP
cord-007689-0vpp3xdl	371	17	Inducers	Inducers	NNPS
cord-007689-0vpp3xdl	371	18	of	of	IN
cord-007689-0vpp3xdl	371	19	interferon	interferon	NN
cord-007689-0vpp3xdl	371	20	and	and	CC
cord-007689-0vpp3xdl	371	21	host	host	NN
cord-007689-0vpp3xdl	371	22	resistance	resistance	NN
cord-007689-0vpp3xdl	371	23	.	.	.
cord-007689-0vpp3xdl	372	1	II	II	NNP
cord-007689-0vpp3xdl	372	2	.	.	.
cord-007689-0vpp3xdl	373	1	Multistranded	multistranded	JJ
cord-007689-0vpp3xdl	373	2	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	373	3	polynucleotide	polynucleotide	JJ
cord-007689-0vpp3xdl	373	4	complexes	complexes	JJ
cord-007689-0vpp3xdl	373	5	LPS	LPS	NNP
cord-007689-0vpp3xdl	373	6	-	-	HYPH
cord-007689-0vpp3xdl	373	7	TLR4	TLR4	NNP
cord-007689-0vpp3xdl	373	8	signaling	signal	VBG
cord-007689-0vpp3xdl	373	9	to	to	IN
cord-007689-0vpp3xdl	373	10	IRF-3/7	irf-3/7	NN
cord-007689-0vpp3xdl	373	11	and	and	CC
cord-007689-0vpp3xdl	373	12	NF	NF	NNP
cord-007689-0vpp3xdl	373	13	-	-	HYPH
cord-007689-0vpp3xdl	373	14	kappaB	kappaB	NNP
cord-007689-0vpp3xdl	373	15	involves	involve	VBZ
cord-007689-0vpp3xdl	373	16	the	the	DT
cord-007689-0vpp3xdl	373	17	toll	toll	NN
cord-007689-0vpp3xdl	373	18	adapters	adapter	NNS
cord-007689-0vpp3xdl	373	19	TRAM	TRAM	NNP
cord-007689-0vpp3xdl	373	20	and	and	CC
cord-007689-0vpp3xdl	373	21	TRIF	TRIF	NNP
cord-007689-0vpp3xdl	373	22	Ribosome	Ribosome	NNP
cord-007689-0vpp3xdl	373	23	assembly	assembly	NN
cord-007689-0vpp3xdl	373	24	in	in	IN
cord-007689-0vpp3xdl	373	25	eukaryotes	eukaryote	NNS
cord-007689-0vpp3xdl	373	26	Viral	viral	JJ
cord-007689-0vpp3xdl	373	27	and	and	CC
cord-007689-0vpp3xdl	373	28	cellular	cellular	JJ
cord-007689-0vpp3xdl	374	1	mRNA	mrna	NN
cord-007689-0vpp3xdl	374	2	capping	cap	VBG
cord-007689-0vpp3xdl	374	3	:	:	:
cord-007689-0vpp3xdl	374	4	past	past	NN
cord-007689-0vpp3xdl	374	5	and	and	CC
cord-007689-0vpp3xdl	374	6	prospects	prospect	NNS
cord-007689-0vpp3xdl	374	7	Essential	essential	JJ
cord-007689-0vpp3xdl	374	8	role	role	NN
cord-007689-0vpp3xdl	374	9	of	of	IN
cord-007689-0vpp3xdl	374	10	mda-5	mda-5	DT
cord-007689-0vpp3xdl	374	11	in	in	IN
cord-007689-0vpp3xdl	374	12	type	type	NN
cord-007689-0vpp3xdl	375	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	375	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	375	3	responses	response	NNS
cord-007689-0vpp3xdl	375	4	to	to	IN
cord-007689-0vpp3xdl	375	5	polyriboinosinic	polyriboinosinic	NNP
cord-007689-0vpp3xdl	375	6	:	:	:
cord-007689-0vpp3xdl	375	7	polyribocytidylic	polyribocytidylic	JJ
cord-007689-0vpp3xdl	375	8	acid	acid	NN
cord-007689-0vpp3xdl	375	9	and	and	CC
cord-007689-0vpp3xdl	375	10	encephalomyocarditis	encephalomyocarditis	NNP
cord-007689-0vpp3xdl	375	11	picornavirus	picornavirus	NNP
cord-007689-0vpp3xdl	375	12	Role	role	NN
cord-007689-0vpp3xdl	375	13	of	of	IN
cord-007689-0vpp3xdl	375	14	interferon	interferon	NN
cord-007689-0vpp3xdl	375	15	in	in	IN
cord-007689-0vpp3xdl	375	16	the	the	DT
cord-007689-0vpp3xdl	375	17	pathogenesis	pathogenesis	NN
cord-007689-0vpp3xdl	375	18	of	of	IN
cord-007689-0vpp3xdl	375	19	virus	virus	NN
cord-007689-0vpp3xdl	375	20	diseases	disease	NNS
cord-007689-0vpp3xdl	375	21	in	in	IN
cord-007689-0vpp3xdl	375	22	mice	mouse	NNS
cord-007689-0vpp3xdl	375	23	as	as	IN
cord-007689-0vpp3xdl	375	24	demonstrated	demonstrate	VBN
cord-007689-0vpp3xdl	375	25	by	by	IN
cord-007689-0vpp3xdl	375	26	the	the	DT
cord-007689-0vpp3xdl	375	27	use	use	NN
cord-007689-0vpp3xdl	375	28	of	of	IN
cord-007689-0vpp3xdl	375	29	antiinterferon	antiinterferon	NNP
cord-007689-0vpp3xdl	375	30	serum	serum	NN
cord-007689-0vpp3xdl	375	31	.	.	.
cord-007689-0vpp3xdl	376	1	I.	I.	NNP
cord-007689-0vpp3xdl	376	2	Rapid	Rapid	NNP
cord-007689-0vpp3xdl	376	3	evolution	evolution	NN
cord-007689-0vpp3xdl	376	4	of	of	IN
cord-007689-0vpp3xdl	376	5	encephalomyocarditis	encephalomyocarditis	NNP
cord-007689-0vpp3xdl	376	6	virus	virus	NN
cord-007689-0vpp3xdl	376	7	infection	infection	NN
cord-007689-0vpp3xdl	376	8	Specificity	Specificity	NNP
cord-007689-0vpp3xdl	376	9	in	in	IN
cord-007689-0vpp3xdl	376	10	Toll	Toll	NNP
cord-007689-0vpp3xdl	376	11	-	-	HYPH
cord-007689-0vpp3xdl	376	12	like	like	JJ
cord-007689-0vpp3xdl	376	13	receptor	receptor	NN
cord-007689-0vpp3xdl	376	14	signalling	signal	VBG
cord-007689-0vpp3xdl	376	15	through	through	IN
cord-007689-0vpp3xdl	376	16	distinct	distinct	JJ
cord-007689-0vpp3xdl	376	17	effector	effector	NN
cord-007689-0vpp3xdl	376	18	functions	function	NNS
cord-007689-0vpp3xdl	376	19	of	of	IN
cord-007689-0vpp3xdl	376	20	TRAF3	traf3	NN
cord-007689-0vpp3xdl	376	21	and	and	CC
cord-007689-0vpp3xdl	376	22	TRAF6	TRAF6	NNP
cord-007689-0vpp3xdl	376	23	Sequence	sequence	NN
cord-007689-0vpp3xdl	376	24	,	,	,
cord-007689-0vpp3xdl	376	25	chemical	chemical	NN
cord-007689-0vpp3xdl	376	26	,	,	,
cord-007689-0vpp3xdl	376	27	and	and	CC
cord-007689-0vpp3xdl	376	28	structural	structural	JJ
cord-007689-0vpp3xdl	376	29	variation	variation	NN
cord-007689-0vpp3xdl	376	30	of	of	IN
cord-007689-0vpp3xdl	376	31	small	small	JJ
cord-007689-0vpp3xdl	376	32	interfering	interfere	VBG
cord-007689-0vpp3xdl	376	33	RNAs	rna	NNS
cord-007689-0vpp3xdl	376	34	and	and	CC
cord-007689-0vpp3xdl	376	35	short	short	JJ
cord-007689-0vpp3xdl	376	36	hairpin	hairpin	NN
cord-007689-0vpp3xdl	376	37	RNAs	rna	NNS
cord-007689-0vpp3xdl	376	38	and	and	CC
cord-007689-0vpp3xdl	376	39	the	the	DT
cord-007689-0vpp3xdl	376	40	effect	effect	NN
cord-007689-0vpp3xdl	376	41	on	on	IN
cord-007689-0vpp3xdl	376	42	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	376	43	gene	gene	NN
cord-007689-0vpp3xdl	376	44	silencing	silence	VBG
cord-007689-0vpp3xdl	376	45	Rational	rational	JJ
cord-007689-0vpp3xdl	376	46	design	design	NN
cord-007689-0vpp3xdl	376	47	of	of	IN
cord-007689-0vpp3xdl	376	48	new	new	JJ
cord-007689-0vpp3xdl	376	49	CpG	CpG	NNP
cord-007689-0vpp3xdl	376	50	oligonucleotides	oligonucleotide	NNS
cord-007689-0vpp3xdl	376	51	that	that	WDT
cord-007689-0vpp3xdl	376	52	combine	combine	VBP
cord-007689-0vpp3xdl	376	53	B	b	NN
cord-007689-0vpp3xdl	376	54	cell	cell	NN
cord-007689-0vpp3xdl	376	55	activation	activation	NN
cord-007689-0vpp3xdl	376	56	with	with	IN
cord-007689-0vpp3xdl	376	57	high	high	JJ
cord-007689-0vpp3xdl	376	58	IFN	IFN	NNP
cord-007689-0vpp3xdl	376	59	-	-	HYPH
cord-007689-0vpp3xdl	376	60	alpha	alpha	NN
cord-007689-0vpp3xdl	376	61	induction	induction	NN
cord-007689-0vpp3xdl	376	62	in	in	IN
cord-007689-0vpp3xdl	376	63	plasmacytoid	plasmacytoid	NNP
cord-007689-0vpp3xdl	376	64	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	376	65	cells	cell	NNS
cord-007689-0vpp3xdl	376	66	Mechanism	Mechanism	NNP
cord-007689-0vpp3xdl	376	67	and	and	CC
cord-007689-0vpp3xdl	376	68	function	function	NN
cord-007689-0vpp3xdl	376	69	of	of	IN
cord-007689-0vpp3xdl	376	70	a	a	DT
cord-007689-0vpp3xdl	376	71	newly	newly	RB
cord-007689-0vpp3xdl	376	72	identified	identify	VBN
cord-007689-0vpp3xdl	376	73	CpG	CpG	NNP
cord-007689-0vpp3xdl	376	74	DNA	DNA	NNP
cord-007689-0vpp3xdl	376	75	motif	motif	NN
cord-007689-0vpp3xdl	376	76	in	in	IN
cord-007689-0vpp3xdl	376	77	human	human	JJ
cord-007689-0vpp3xdl	376	78	primary	primary	NN
cord-007689-0vpp3xdl	376	79	B	B	NNP
cord-007689-0vpp3xdl	376	80	cells	cell	NNS
cord-007689-0vpp3xdl	377	1	Species	species	NN
cord-007689-0vpp3xdl	377	2	-	-	HYPH
cord-007689-0vpp3xdl	377	3	specific	specific	JJ
cord-007689-0vpp3xdl	377	4	recognition	recognition	NN
cord-007689-0vpp3xdl	377	5	of	of	IN
cord-007689-0vpp3xdl	377	6	single	single	RB
cord-007689-0vpp3xdl	377	7	-	-	HYPH
cord-007689-0vpp3xdl	377	8	stranded	strand	VBN
cord-007689-0vpp3xdl	377	9	RNA	RNA	NNP
cord-007689-0vpp3xdl	377	10	via	via	IN
cord-007689-0vpp3xdl	377	11	tolllike	tolllike	NN
cord-007689-0vpp3xdl	377	12	receptor	receptor	NNP
cord-007689-0vpp3xdl	377	13	7	7	CD
cord-007689-0vpp3xdl	377	14	and	and	CC
cord-007689-0vpp3xdl	377	15	8	8	CD
cord-007689-0vpp3xdl	377	16	Small	small	JJ
cord-007689-0vpp3xdl	377	17	anti	anti	JJ
cord-007689-0vpp3xdl	377	18	-	-	JJ
cord-007689-0vpp3xdl	377	19	viral	viral	JJ
cord-007689-0vpp3xdl	377	20	compounds	compound	NNS
cord-007689-0vpp3xdl	377	21	activate	activate	VBP
cord-007689-0vpp3xdl	377	22	immune	immune	JJ
cord-007689-0vpp3xdl	377	23	cells	cell	NNS
cord-007689-0vpp3xdl	377	24	via	via	IN
cord-007689-0vpp3xdl	377	25	the	the	DT
cord-007689-0vpp3xdl	377	26	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	377	27	MyD88-dependent	MyD88-dependent	NNP
cord-007689-0vpp3xdl	377	28	signaling	signal	VBG
cord-007689-0vpp3xdl	377	29	pathway	pathway	NN
cord-007689-0vpp3xdl	378	1	A	a	DT
cord-007689-0vpp3xdl	378	2	Toll	toll	NN
cord-007689-0vpp3xdl	378	3	-	-	HYPH
cord-007689-0vpp3xdl	378	4	like	like	JJ
cord-007689-0vpp3xdl	378	5	receptor	receptor	NN
cord-007689-0vpp3xdl	378	6	recognizes	recognize	VBZ
cord-007689-0vpp3xdl	378	7	bacterial	bacterial	JJ
cord-007689-0vpp3xdl	378	8	DNA	DNA	NNP
cord-007689-0vpp3xdl	378	9	Identification	Identification	NNP
cord-007689-0vpp3xdl	378	10	of	of	IN
cord-007689-0vpp3xdl	378	11	the	the	DT
cord-007689-0vpp3xdl	378	12	5′	5′	CD
cord-007689-0vpp3xdl	378	13	terminal	terminal	NN
cord-007689-0vpp3xdl	378	14	structure	structure	NN
cord-007689-0vpp3xdl	378	15	of	of	IN
cord-007689-0vpp3xdl	378	16	influenza	influenza	NN
cord-007689-0vpp3xdl	378	17	virus	virus	NN
cord-007689-0vpp3xdl	378	18	genome	genome	NN
cord-007689-0vpp3xdl	378	19	RNA	RNA	NNP
cord-007689-0vpp3xdl	378	20	by	by	IN
cord-007689-0vpp3xdl	378	21	a	a	DT
cord-007689-0vpp3xdl	378	22	newly	newly	RB
cord-007689-0vpp3xdl	378	23	developed	develop	VBN
cord-007689-0vpp3xdl	378	24	enzymatic	enzymatic	JJ
cord-007689-0vpp3xdl	378	25	method	method	NN
cord-007689-0vpp3xdl	378	26	Role	role	NN
cord-007689-0vpp3xdl	378	27	of	of	IN
cord-007689-0vpp3xdl	378	28	a	a	DT
cord-007689-0vpp3xdl	378	29	transductional	transductional	JJ
cord-007689-0vpp3xdl	378	30	-	-	HYPH
cord-007689-0vpp3xdl	378	31	transcriptional	transcriptional	NN
cord-007689-0vpp3xdl	378	32	processor	processor	NN
cord-007689-0vpp3xdl	378	33	complex	complex	NN
cord-007689-0vpp3xdl	378	34	involving	involve	VBG
cord-007689-0vpp3xdl	378	35	MyD88	MyD88	NNP
cord-007689-0vpp3xdl	378	36	and	and	CC
cord-007689-0vpp3xdl	378	37	IRF-7	IRF-7	NNP
cord-007689-0vpp3xdl	378	38	in	in	IN
cord-007689-0vpp3xdl	378	39	Toll	Toll	NNP
cord-007689-0vpp3xdl	378	40	-	-	HYPH
cord-007689-0vpp3xdl	378	41	like	like	JJ
cord-007689-0vpp3xdl	378	42	receptor	receptor	NN
cord-007689-0vpp3xdl	378	43	signaling	signal	VBG
cord-007689-0vpp3xdl	378	44	5′-Triphosphate	5′-triphosphate	CD
cord-007689-0vpp3xdl	378	45	RNA	RNA	NNP
cord-007689-0vpp3xdl	378	46	is	be	VBZ
cord-007689-0vpp3xdl	378	47	the	the	DT
cord-007689-0vpp3xdl	378	48	ligand	ligand	NN
cord-007689-0vpp3xdl	378	49	for	for	IN
cord-007689-0vpp3xdl	378	50	RIG-	RIG-	NNP
cord-007689-0vpp3xdl	379	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	379	2	Sequence	sequence	NN
cord-007689-0vpp3xdl	379	3	-	-	HYPH
cord-007689-0vpp3xdl	379	4	specific	specific	JJ
cord-007689-0vpp3xdl	379	5	potent	potent	JJ
cord-007689-0vpp3xdl	379	6	induction	induction	NN
cord-007689-0vpp3xdl	379	7	of	of	IN
cord-007689-0vpp3xdl	379	8	IFN	IFN	NNP
cord-007689-0vpp3xdl	379	9	-	-	HYPH
cord-007689-0vpp3xdl	379	10	alpha	alpha	NN
cord-007689-0vpp3xdl	379	11	by	by	IN
cord-007689-0vpp3xdl	379	12	short	short	JJ
cord-007689-0vpp3xdl	379	13	interfering	interfere	VBG
cord-007689-0vpp3xdl	379	14	RNA	RNA	NNP
cord-007689-0vpp3xdl	379	15	in	in	IN
cord-007689-0vpp3xdl	379	16	plasmacytoid	plasmacytoid	NNP
cord-007689-0vpp3xdl	379	17	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	379	18	cells	cell	NNS
cord-007689-0vpp3xdl	379	19	through	through	IN
cord-007689-0vpp3xdl	379	20	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	379	21	Quantitative	quantitative	JJ
cord-007689-0vpp3xdl	379	22	expression	expression	NN
cord-007689-0vpp3xdl	379	23	of	of	IN
cord-007689-0vpp3xdl	379	24	toll	toll	NN
cord-007689-0vpp3xdl	379	25	-	-	HYPH
cord-007689-0vpp3xdl	379	26	like	like	JJ
cord-007689-0vpp3xdl	379	27	receptor	receptor	NN
cord-007689-0vpp3xdl	379	28	1	1	CD
cord-007689-0vpp3xdl	379	29	-	-	SYM
cord-007689-0vpp3xdl	379	30	10	10	CD
cord-007689-0vpp3xdl	379	31	mRNA	mrna	NN
cord-007689-0vpp3xdl	379	32	in	in	IN
cord-007689-0vpp3xdl	379	33	cellular	cellular	JJ
cord-007689-0vpp3xdl	379	34	subsets	subset	NNS
cord-007689-0vpp3xdl	379	35	of	of	IN
cord-007689-0vpp3xdl	379	36	human	human	JJ
cord-007689-0vpp3xdl	379	37	peripheral	peripheral	JJ
cord-007689-0vpp3xdl	379	38	blood	blood	NN
cord-007689-0vpp3xdl	379	39	mononuclear	mononuclear	NN
cord-007689-0vpp3xdl	379	40	cells	cell	NNS
cord-007689-0vpp3xdl	379	41	and	and	CC
cord-007689-0vpp3xdl	379	42	sensitivity	sensitivity	NN
cord-007689-0vpp3xdl	379	43	to	to	IN
cord-007689-0vpp3xdl	379	44	CpG	CpG	NNP
cord-007689-0vpp3xdl	379	45	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-007689-0vpp3xdl	379	46	Cutting	Cutting	NNP
cord-007689-0vpp3xdl	379	47	edge	edge	NN
cord-007689-0vpp3xdl	379	48	:	:	:
cord-007689-0vpp3xdl	380	1	Toll	toll	NN
cord-007689-0vpp3xdl	380	2	-	-	HYPH
cord-007689-0vpp3xdl	380	3	like	like	JJ
cord-007689-0vpp3xdl	380	4	receptor	receptor	NN
cord-007689-0vpp3xdl	380	5	4	4	CD
cord-007689-0vpp3xdl	381	1	(	(	-LRB-
cord-007689-0vpp3xdl	381	2	TLR4)-deficient	tlr4)-deficient	CD
cord-007689-0vpp3xdl	381	3	mice	mouse	NNS
cord-007689-0vpp3xdl	381	4	are	be	VBP
cord-007689-0vpp3xdl	381	5	hyporesponsive	hyporesponsive	JJ
cord-007689-0vpp3xdl	381	6	to	to	IN
cord-007689-0vpp3xdl	381	7	lipopolysaccharide	lipopolysaccharide	NN
cord-007689-0vpp3xdl	381	8	:	:	:
cord-007689-0vpp3xdl	381	9	evidence	evidence	NN
cord-007689-0vpp3xdl	381	10	for	for	IN
cord-007689-0vpp3xdl	381	11	TLR4	TLR4	NNP
cord-007689-0vpp3xdl	381	12	as	as	IN
cord-007689-0vpp3xdl	381	13	the	the	DT
cord-007689-0vpp3xdl	381	14	Lps	Lps	NNP
cord-007689-0vpp3xdl	381	15	gene	gene	NN
cord-007689-0vpp3xdl	381	16	product	product	NN
cord-007689-0vpp3xdl	381	17	Synthesis	Synthesis	NNP
cord-007689-0vpp3xdl	381	18	of	of	IN
cord-007689-0vpp3xdl	381	19	low	low	JJ
cord-007689-0vpp3xdl	381	20	molecular	molecular	JJ
cord-007689-0vpp3xdl	381	21	weight	weight	NN
cord-007689-0vpp3xdl	381	22	inhibitor	inhibitor	NN
cord-007689-0vpp3xdl	381	23	of	of	IN
cord-007689-0vpp3xdl	381	24	protein	protein	NN
cord-007689-0vpp3xdl	381	25	synthesis	synthesis	NN
cord-007689-0vpp3xdl	381	26	with	with	IN
cord-007689-0vpp3xdl	381	27	enzyme	enzyme	NN
cord-007689-0vpp3xdl	381	28	from	from	IN
cord-007689-0vpp3xdl	381	29	interferon	interferon	NN
cord-007689-0vpp3xdl	381	30	-	-	HYPH
cord-007689-0vpp3xdl	381	31	treated	treat	VBN
cord-007689-0vpp3xdl	381	32	cells	cell	NNS
cord-007689-0vpp3xdl	381	33	Activation	activation	NN
cord-007689-0vpp3xdl	381	34	of	of	IN
cord-007689-0vpp3xdl	381	35	NF	NF	NNP
cord-007689-0vpp3xdl	381	36	-	-	HYPH
cord-007689-0vpp3xdl	381	37	kappaB	kappaB	NNP
cord-007689-0vpp3xdl	381	38	by	by	IN
cord-007689-0vpp3xdl	381	39	doublestranded	doublestranded	NNP
cord-007689-0vpp3xdl	381	40	RNA	RNA	NNP
cord-007689-0vpp3xdl	381	41	(	(	-LRB-
cord-007689-0vpp3xdl	381	42	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	381	43	)	)	-RRB-
cord-007689-0vpp3xdl	382	1	in	in	IN
cord-007689-0vpp3xdl	382	2	the	the	DT
cord-007689-0vpp3xdl	382	3	absence	absence	NN
cord-007689-0vpp3xdl	382	4	of	of	IN
cord-007689-0vpp3xdl	382	5	protein	protein	NN
cord-007689-0vpp3xdl	382	6	kinase	kinase	NN
cord-007689-0vpp3xdl	382	7	R	r	NN
cord-007689-0vpp3xdl	382	8	and	and	CC
cord-007689-0vpp3xdl	382	9	RNase	RNase	NNP
cord-007689-0vpp3xdl	382	10	L	L	NNP
cord-007689-0vpp3xdl	382	11	demonstrates	demonstrate	VBZ
cord-007689-0vpp3xdl	382	12	the	the	DT
cord-007689-0vpp3xdl	382	13	existence	existence	NN
cord-007689-0vpp3xdl	382	14	of	of	IN
cord-007689-0vpp3xdl	382	15	two	two	CD
cord-007689-0vpp3xdl	382	16	separate	separate	JJ
cord-007689-0vpp3xdl	382	17	dsRNA	dsrna	NN
cord-007689-0vpp3xdl	382	18	-	-	HYPH
cord-007689-0vpp3xdl	382	19	triggered	trigger	VBN
cord-007689-0vpp3xdl	382	20	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	382	21	programs	program	NNS
cord-007689-0vpp3xdl	382	22	Foreign	foreign	JJ
cord-007689-0vpp3xdl	382	23	nucleic	nucleic	JJ
cord-007689-0vpp3xdl	382	24	acids	acid	NNS
cord-007689-0vpp3xdl	382	25	as	as	IN
cord-007689-0vpp3xdl	382	26	the	the	DT
cord-007689-0vpp3xdl	382	27	stimulus	stimulus	NN
cord-007689-0vpp3xdl	382	28	to	to	TO
cord-007689-0vpp3xdl	382	29	make	make	VB
cord-007689-0vpp3xdl	382	30	interferon	interferon	NN
cord-007689-0vpp3xdl	382	31	Virus	virus	NN
cord-007689-0vpp3xdl	382	32	interference	interference	NN
cord-007689-0vpp3xdl	382	33	.	.	.
cord-007689-0vpp3xdl	383	1	I.	I.	NNP
cord-007689-0vpp3xdl	384	1	The	the	DT
cord-007689-0vpp3xdl	384	2	interferon	interferon	NN
cord-007689-0vpp3xdl	385	1	Approaching	approach	VBG
cord-007689-0vpp3xdl	385	2	the	the	DT
cord-007689-0vpp3xdl	385	3	asymptote	asymptote	NN
cord-007689-0vpp3xdl	385	4	?	?	.
cord-007689-0vpp3xdl	386	1	Evolution	evolution	NN
cord-007689-0vpp3xdl	386	2	and	and	CC
cord-007689-0vpp3xdl	386	3	revolution	revolution	NN
cord-007689-0vpp3xdl	386	4	in	in	IN
cord-007689-0vpp3xdl	386	5	immunology	immunology	NN
cord-007689-0vpp3xdl	386	6	Sequencedependent	Sequencedependent	NNP
cord-007689-0vpp3xdl	386	7	stimulation	stimulation	NN
cord-007689-0vpp3xdl	386	8	of	of	IN
cord-007689-0vpp3xdl	386	9	the	the	DT
cord-007689-0vpp3xdl	386	10	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	386	11	innate	innate	JJ
cord-007689-0vpp3xdl	386	12	immune	immune	JJ
cord-007689-0vpp3xdl	386	13	response	response	NN
cord-007689-0vpp3xdl	386	14	by	by	IN
cord-007689-0vpp3xdl	386	15	synthetic	synthetic	JJ
cord-007689-0vpp3xdl	386	16	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	386	17	Human	Human	NNP
cord-007689-0vpp3xdl	386	18	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	386	19	or	or	CC
cord-007689-0vpp3xdl	386	20	TLR8	TLR8	NNP
cord-007689-0vpp3xdl	386	21	independently	independently	RB
cord-007689-0vpp3xdl	386	22	confer	confer	VB
cord-007689-0vpp3xdl	386	23	responsiveness	responsiveness	NN
cord-007689-0vpp3xdl	386	24	to	to	IN
cord-007689-0vpp3xdl	386	25	the	the	DT
cord-007689-0vpp3xdl	386	26	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	386	27	compound	compound	NN
cord-007689-0vpp3xdl	386	28	R-848	r-848	NN
cord-007689-0vpp3xdl	386	29	Expression	expression	NN
cord-007689-0vpp3xdl	386	30	analysis	analysis	NN
cord-007689-0vpp3xdl	386	31	and	and	CC
cord-007689-0vpp3xdl	386	32	genomic	genomic	JJ
cord-007689-0vpp3xdl	386	33	characterization	characterization	NN
cord-007689-0vpp3xdl	386	34	of	of	IN
cord-007689-0vpp3xdl	386	35	human	human	JJ
cord-007689-0vpp3xdl	386	36	melanoma	melanoma	NN
cord-007689-0vpp3xdl	386	37	differentiation	differentiation	NN
cord-007689-0vpp3xdl	386	38	associated	associate	VBN
cord-007689-0vpp3xdl	386	39	gene-5	gene-5	NNP
cord-007689-0vpp3xdl	386	40	,	,	,
cord-007689-0vpp3xdl	386	41	mda-5	mda-5	NNP
cord-007689-0vpp3xdl	386	42	:	:	:
cord-007689-0vpp3xdl	386	43	a	a	DT
cord-007689-0vpp3xdl	386	44	novel	novel	JJ
cord-007689-0vpp3xdl	386	45	type	type	NN
cord-007689-0vpp3xdl	386	46	I	-PRON-	PRP
cord-007689-0vpp3xdl	386	47	interferon	interferon	NN
cord-007689-0vpp3xdl	386	48	-	-	HYPH
cord-007689-0vpp3xdl	386	49	responsive	responsive	JJ
cord-007689-0vpp3xdl	386	50	apoptosisinducing	apoptosisinducing	NN
cord-007689-0vpp3xdl	386	51	gene	gene	NN
cord-007689-0vpp3xdl	386	52	mda-5	mda-5	NNP
cord-007689-0vpp3xdl	386	53	:	:	:
cord-007689-0vpp3xdl	386	54	An	an	DT
cord-007689-0vpp3xdl	386	55	interferon	interferon	NN
cord-007689-0vpp3xdl	386	56	-	-	HYPH
cord-007689-0vpp3xdl	386	57	inducible	inducible	JJ
cord-007689-0vpp3xdl	386	58	putative	putative	JJ
cord-007689-0vpp3xdl	386	59	RNA	RNA	NNP
cord-007689-0vpp3xdl	386	60	helicase	helicase	NN
cord-007689-0vpp3xdl	386	61	with	with	IN
cord-007689-0vpp3xdl	386	62	double	double	RB
cord-007689-0vpp3xdl	386	63	-	-	HYPH
cord-007689-0vpp3xdl	386	64	stranded	strand	VBN
cord-007689-0vpp3xdl	386	65	RNA	rna	NN
cord-007689-0vpp3xdl	386	66	-	-	HYPH
cord-007689-0vpp3xdl	386	67	dependent	dependent	JJ
cord-007689-0vpp3xdl	386	68	ATPase	ATPase	NNP
cord-007689-0vpp3xdl	386	69	activity	activity	NN
cord-007689-0vpp3xdl	386	70	and	and	CC
cord-007689-0vpp3xdl	386	71	melanoma	melanoma	NN
cord-007689-0vpp3xdl	386	72	growth	growth	NN
cord-007689-0vpp3xdl	386	73	-	-	HYPH
cord-007689-0vpp3xdl	386	74	suppressive	suppressive	JJ
cord-007689-0vpp3xdl	386	75	properties	property	NNS
cord-007689-0vpp3xdl	386	76	De	De	NNP
cord-007689-0vpp3xdl	386	77	novo	novo	NN
cord-007689-0vpp3xdl	386	78	initiation	initiation	NN
cord-007689-0vpp3xdl	386	79	of	of	IN
cord-007689-0vpp3xdl	386	80	viral	viral	JJ
cord-007689-0vpp3xdl	386	81	RNA	RNA	NNP
cord-007689-0vpp3xdl	386	82	-	-	HYPH
cord-007689-0vpp3xdl	386	83	dependent	dependent	JJ
cord-007689-0vpp3xdl	386	84	RNA	RNA	NNP
cord-007689-0vpp3xdl	386	85	synthesis	synthesis	NN
cord-007689-0vpp3xdl	386	86	Small	small	JJ
cord-007689-0vpp3xdl	386	87	interfering	interfere	VBG
cord-007689-0vpp3xdl	386	88	RNAs	rna	NNS
cord-007689-0vpp3xdl	386	89	mediate	mediate	VBP
cord-007689-0vpp3xdl	386	90	sequence	sequence	NN
cord-007689-0vpp3xdl	386	91	-	-	HYPH
cord-007689-0vpp3xdl	386	92	independent	independent	JJ
cord-007689-0vpp3xdl	386	93	gene	gene	NN
cord-007689-0vpp3xdl	386	94	suppression	suppression	NN
cord-007689-0vpp3xdl	386	95	and	and	CC
cord-007689-0vpp3xdl	386	96	induce	induce	VB
cord-007689-0vpp3xdl	386	97	immune	immune	JJ
cord-007689-0vpp3xdl	386	98	activation	activation	NN
cord-007689-0vpp3xdl	386	99	by	by	IN
cord-007689-0vpp3xdl	386	100	signaling	signal	VBG
cord-007689-0vpp3xdl	386	101	through	through	IN
cord-007689-0vpp3xdl	386	102	toll	toll	NN
cord-007689-0vpp3xdl	386	103	-	-	HYPH
cord-007689-0vpp3xdl	386	104	like	like	JJ
cord-007689-0vpp3xdl	386	105	receptor	receptor	NN
cord-007689-0vpp3xdl	386	106	3	3	CD
cord-007689-0vpp3xdl	386	107	Suppression	Suppression	NNP
cord-007689-0vpp3xdl	386	108	of	of	IN
cord-007689-0vpp3xdl	386	109	RNA	RNA	NNP
cord-007689-0vpp3xdl	386	110	recognition	recognition	NN
cord-007689-0vpp3xdl	386	111	by	by	IN
cord-007689-0vpp3xdl	386	112	Toll	Toll	NNP
cord-007689-0vpp3xdl	386	113	-	-	HYPH
cord-007689-0vpp3xdl	386	114	like	like	JJ
cord-007689-0vpp3xdl	386	115	receptors	receptor	NNS
cord-007689-0vpp3xdl	386	116	:	:	:
cord-007689-0vpp3xdl	386	117	the	the	DT
cord-007689-0vpp3xdl	386	118	impact	impact	NN
cord-007689-0vpp3xdl	386	119	of	of	IN
cord-007689-0vpp3xdl	386	120	nucleoside	nucleoside	JJ
cord-007689-0vpp3xdl	386	121	modification	modification	NN
cord-007689-0vpp3xdl	386	122	and	and	CC
cord-007689-0vpp3xdl	386	123	the	the	DT
cord-007689-0vpp3xdl	386	124	evolutionary	evolutionary	JJ
cord-007689-0vpp3xdl	386	125	origin	origin	NN
cord-007689-0vpp3xdl	386	126	of	of	IN
cord-007689-0vpp3xdl	386	127	RNA	RNA	NNP
cord-007689-0vpp3xdl	386	128	Cell	Cell	NNP
cord-007689-0vpp3xdl	386	129	type	type	NN
cord-007689-0vpp3xdl	386	130	-	-	HYPH
cord-007689-0vpp3xdl	386	131	specific	specific	JJ
cord-007689-0vpp3xdl	386	132	involvement	involvement	NN
cord-007689-0vpp3xdl	386	133	of	of	IN
cord-007689-0vpp3xdl	386	134	RIG	rig	NN
cord-007689-0vpp3xdl	386	135	-	-	:
cord-007689-0vpp3xdl	386	136	I	-PRON-	PRP
cord-007689-0vpp3xdl	386	137	in	in	IN
cord-007689-0vpp3xdl	386	138	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	386	139	response	response	NN
cord-007689-0vpp3xdl	386	140	Differential	differential	JJ
cord-007689-0vpp3xdl	386	141	roles	role	NNS
cord-007689-0vpp3xdl	386	142	of	of	IN
cord-007689-0vpp3xdl	386	143	MDA5	MDA5	NNP
cord-007689-0vpp3xdl	386	144	and	and	CC
cord-007689-0vpp3xdl	386	145	RIG	rig	NN
cord-007689-0vpp3xdl	387	1	-I	-i	DT
cord-007689-0vpp3xdl	387	2	helicases	helicase	NNS
cord-007689-0vpp3xdl	387	3	in	in	IN
cord-007689-0vpp3xdl	387	4	the	the	DT
cord-007689-0vpp3xdl	387	5	recognition	recognition	NN
cord-007689-0vpp3xdl	387	6	of	of	IN
cord-007689-0vpp3xdl	387	7	RNA	RNA	NNP
cord-007689-0vpp3xdl	387	8	viruses	virus	NNS
cord-007689-0vpp3xdl	387	9	Interferon	interferon	NN
cord-007689-0vpp3xdl	387	10	-	-	HYPH
cord-007689-0vpp3xdl	387	11	alpha	alpha	NN
cord-007689-0vpp3xdl	387	12	induction	induction	NN
cord-007689-0vpp3xdl	387	13	through	through	IN
cord-007689-0vpp3xdl	387	14	Tolllike	Tolllike	NNP
cord-007689-0vpp3xdl	387	15	receptors	receptor	NNS
cord-007689-0vpp3xdl	387	16	involves	involve	VBZ
cord-007689-0vpp3xdl	387	17	a	a	DT
cord-007689-0vpp3xdl	387	18	direct	direct	JJ
cord-007689-0vpp3xdl	387	19	interaction	interaction	NN
cord-007689-0vpp3xdl	387	20	of	of	IN
cord-007689-0vpp3xdl	387	21	IRF7	IRF7	NNP
cord-007689-0vpp3xdl	387	22	with	with	IN
cord-007689-0vpp3xdl	387	23	MyD88	MyD88	NNPS
cord-007689-0vpp3xdl	387	24	and	and	CC
cord-007689-0vpp3xdl	387	25	TRAF6	TRAF6	''
cord-007689-0vpp3xdl	387	26	IPS-1	IPS-1	NNP
cord-007689-0vpp3xdl	387	27	,	,	,
cord-007689-0vpp3xdl	388	1	an	an	DT
cord-007689-0vpp3xdl	388	2	adaptor	adaptor	NN
cord-007689-0vpp3xdl	388	3	triggering	trigger	VBG
cord-007689-0vpp3xdl	388	4	RIG	rig	NN
cord-007689-0vpp3xdl	388	5	-	-	HYPH
cord-007689-0vpp3xdl	388	6	I	i	NN
cord-007689-0vpp3xdl	388	7	-	-	HYPH
cord-007689-0vpp3xdl	388	8	and	and	CC
cord-007689-0vpp3xdl	388	9	Mda5-mediated	Mda5-mediated	NNP
cord-007689-0vpp3xdl	388	10	type	type	NN
cord-007689-0vpp3xdl	389	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	389	2	interferon	interferon	RB
cord-007689-0vpp3xdl	389	3	induction	induction	NN
cord-007689-0vpp3xdl	390	1	Interferon	interferon	NN
cord-007689-0vpp3xdl	390	2	induction	induction	NN
cord-007689-0vpp3xdl	390	3	by	by	IN
cord-007689-0vpp3xdl	390	4	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	390	5	and	and	CC
cord-007689-0vpp3xdl	390	6	ssRNAs	ssRNAs	NNP
cord-007689-0vpp3xdl	390	7	synthesized	synthesize	VBN
cord-007689-0vpp3xdl	390	8	by	by	IN
cord-007689-0vpp3xdl	390	9	phage	phage	NN
cord-007689-0vpp3xdl	390	10	polymerase	polymerase	NN
cord-007689-0vpp3xdl	390	11	Overexpression	Overexpression	NNP
cord-007689-0vpp3xdl	390	12	of	of	IN
cord-007689-0vpp3xdl	390	13	Helicard	Helicard	NNP
cord-007689-0vpp3xdl	390	14	,	,	,
cord-007689-0vpp3xdl	391	1	a	a	DT
cord-007689-0vpp3xdl	391	2	CARD	card	NN
cord-007689-0vpp3xdl	391	3	-	-	HYPH
cord-007689-0vpp3xdl	391	4	containing	contain	VBG
cord-007689-0vpp3xdl	391	5	helicase	helicase	NN
cord-007689-0vpp3xdl	391	6	cleaved	cleave	VBN
cord-007689-0vpp3xdl	391	7	during	during	IN
cord-007689-0vpp3xdl	391	8	apoptosis	apoptosis	NN
cord-007689-0vpp3xdl	391	9	,	,	,
cord-007689-0vpp3xdl	391	10	accelerates	accelerate	VBZ
cord-007689-0vpp3xdl	391	11	DNA	dna	NN
cord-007689-0vpp3xdl	391	12	degradation	degradation	NN
cord-007689-0vpp3xdl	391	13	TLR9-dependent	TLR9-dependent	NNP
cord-007689-0vpp3xdl	391	14	recognition	recognition	NN
cord-007689-0vpp3xdl	391	15	of	of	IN
cord-007689-0vpp3xdl	391	16	MCMV	MCMV	NNP
cord-007689-0vpp3xdl	391	17	by	by	IN
cord-007689-0vpp3xdl	391	18	IPC	IPC	NNP
cord-007689-0vpp3xdl	391	19	and	and	CC
cord-007689-0vpp3xdl	391	20	DC	DC	NNP
cord-007689-0vpp3xdl	391	21	generates	generate	VBZ
cord-007689-0vpp3xdl	391	22	coordinated	coordinated	JJ
cord-007689-0vpp3xdl	391	23	cytokine	cytokine	NN
cord-007689-0vpp3xdl	391	24	responses	response	NNS
cord-007689-0vpp3xdl	391	25	that	that	WDT
cord-007689-0vpp3xdl	391	26	activate	activate	VBP
cord-007689-0vpp3xdl	391	27	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	391	28	NK	NK	NNP
cord-007689-0vpp3xdl	391	29	cell	cell	NN
cord-007689-0vpp3xdl	391	30	function	function	NN
cord-007689-0vpp3xdl	391	31	Herpes	Herpes	NNP
cord-007689-0vpp3xdl	391	32	simplex	simplex	NN
cord-007689-0vpp3xdl	391	33	virus	virus	NN
cord-007689-0vpp3xdl	391	34	type	type	NN
cord-007689-0vpp3xdl	391	35	1	1	CD
cord-007689-0vpp3xdl	391	36	activates	activate	VBZ
cord-007689-0vpp3xdl	391	37	murine	murine	JJ
cord-007689-0vpp3xdl	391	38	natural	natural	JJ
cord-007689-0vpp3xdl	391	39	interferon	interferon	NN
cord-007689-0vpp3xdl	391	40	-	-	HYPH
cord-007689-0vpp3xdl	391	41	producing	produce	VBG
cord-007689-0vpp3xdl	391	42	cells	cell	NNS
cord-007689-0vpp3xdl	391	43	through	through	IN
cord-007689-0vpp3xdl	391	44	toll	toll	NN
cord-007689-0vpp3xdl	391	45	-	-	HYPH
cord-007689-0vpp3xdl	391	46	like	like	JJ
cord-007689-0vpp3xdl	391	47	receptor	receptor	NN
cord-007689-0vpp3xdl	391	48	9	9	CD
cord-007689-0vpp3xdl	391	49	Identification	identification	NN
cord-007689-0vpp3xdl	391	50	of	of	IN
cord-007689-0vpp3xdl	391	51	CpG	CpG	NNP
cord-007689-0vpp3xdl	391	52	oligonucleotide	oligonucleotide	NN
cord-007689-0vpp3xdl	391	53	sequences	sequence	NNS
cord-007689-0vpp3xdl	391	54	with	with	IN
cord-007689-0vpp3xdl	391	55	high	high	JJ
cord-007689-0vpp3xdl	391	56	induction	induction	NN
cord-007689-0vpp3xdl	391	57	of	of	IN
cord-007689-0vpp3xdl	391	58	IFN	IFN	NNP
cord-007689-0vpp3xdl	391	59	-	-	HYPH
cord-007689-0vpp3xdl	391	60	alpha	alpha	NN
cord-007689-0vpp3xdl	391	61	/	/	SYM
cord-007689-0vpp3xdl	391	62	beta	beta	NN
cord-007689-0vpp3xdl	391	63	in	in	IN
cord-007689-0vpp3xdl	391	64	plasmacytoid	plasmacytoid	NNP
cord-007689-0vpp3xdl	391	65	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	391	66	cells	cell	NNS
cord-007689-0vpp3xdl	392	1	Toll	toll	NN
cord-007689-0vpp3xdl	392	2	-	-	HYPH
cord-007689-0vpp3xdl	392	3	like	like	JJ
cord-007689-0vpp3xdl	392	4	receptor	receptor	NN
cord-007689-0vpp3xdl	392	5	expression	expression	NN
cord-007689-0vpp3xdl	392	6	reveals	reveal	VBZ
cord-007689-0vpp3xdl	392	7	CpG	CpG	NNP
cord-007689-0vpp3xdl	392	8	DNA	DNA	NNP
cord-007689-0vpp3xdl	392	9	as	as	IN
cord-007689-0vpp3xdl	392	10	a	a	DT
cord-007689-0vpp3xdl	392	11	unique	unique	JJ
cord-007689-0vpp3xdl	392	12	microbial	microbial	JJ
cord-007689-0vpp3xdl	392	13	stimulus	stimulus	NN
cord-007689-0vpp3xdl	392	14	for	for	IN
cord-007689-0vpp3xdl	392	15	plasmacytoid	plasmacytoid	NNP
cord-007689-0vpp3xdl	392	16	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	392	17	cells	cell	NNS
cord-007689-0vpp3xdl	392	18	which	which	WDT
cord-007689-0vpp3xdl	392	19	synergizes	synergize	VBZ
cord-007689-0vpp3xdl	392	20	with	with	IN
cord-007689-0vpp3xdl	392	21	CD40	CD40	NNP
cord-007689-0vpp3xdl	392	22	ligand	ligand	NN
cord-007689-0vpp3xdl	392	23	to	to	TO
cord-007689-0vpp3xdl	392	24	induce	induce	VB
cord-007689-0vpp3xdl	392	25	high	high	JJ
cord-007689-0vpp3xdl	392	26	amounts	amount	NNS
cord-007689-0vpp3xdl	392	27	of	of	IN
cord-007689-0vpp3xdl	392	28	IL-12	IL-12	NNP
cord-007689-0vpp3xdl	392	29	Double	double	RB
cord-007689-0vpp3xdl	392	30	-	-	HYPH
cord-007689-0vpp3xdl	392	31	stranded	strand	VBN
cord-007689-0vpp3xdl	392	32	RNAdependent	rnadependent	NN
cord-007689-0vpp3xdl	392	33	protein	protein	NN
cord-007689-0vpp3xdl	392	34	kinase	kinase	NN
cord-007689-0vpp3xdl	392	35	activates	activate	VBZ
cord-007689-0vpp3xdl	392	36	transcription	transcription	NN
cord-007689-0vpp3xdl	392	37	factor	factor	NN
cord-007689-0vpp3xdl	392	38	NF	nf	NN
cord-007689-0vpp3xdl	392	39	-	-	HYPH
cord-007689-0vpp3xdl	392	40	kappa	kappa	NN
cord-007689-0vpp3xdl	392	41	B	B	NNP
cord-007689-0vpp3xdl	392	42	by	by	IN
cord-007689-0vpp3xdl	392	43	phosphorylating	phosphorylate	VBG
cord-007689-0vpp3xdl	392	44	I	-PRON-	PRP
cord-007689-0vpp3xdl	393	1	kappa	kappa	NNP
cord-007689-0vpp3xdl	393	2	B	B	NNP
cord-007689-0vpp3xdl	393	3	A	A	NNP
cord-007689-0vpp3xdl	393	4	protein	protein	NN
cord-007689-0vpp3xdl	393	5	covalently	covalently	RB
cord-007689-0vpp3xdl	393	6	linked	link	VBN
cord-007689-0vpp3xdl	393	7	to	to	IN
cord-007689-0vpp3xdl	393	8	poliovirus	poliovirus	NN
cord-007689-0vpp3xdl	393	9	genome	genome	NN
cord-007689-0vpp3xdl	393	10	RNA	RNA	NNP
cord-007689-0vpp3xdl	394	1	The	the	DT
cord-007689-0vpp3xdl	394	2	dorsoventral	dorsoventral	JJ
cord-007689-0vpp3xdl	394	3	regulatory	regulatory	JJ
cord-007689-0vpp3xdl	394	4	gene	gene	NN
cord-007689-0vpp3xdl	394	5	cassette	cassette	NN
cord-007689-0vpp3xdl	394	6	spatzle	spatzle	NNP
cord-007689-0vpp3xdl	394	7	/	/	SYM
cord-007689-0vpp3xdl	394	8	Toll	toll	NN
cord-007689-0vpp3xdl	394	9	/	/	SYM
cord-007689-0vpp3xdl	394	10	cactus	cactus	NN
cord-007689-0vpp3xdl	394	11	controls	control	VBZ
cord-007689-0vpp3xdl	394	12	the	the	DT
cord-007689-0vpp3xdl	394	13	potent	potent	JJ
cord-007689-0vpp3xdl	394	14	antifungal	antifungal	JJ
cord-007689-0vpp3xdl	394	15	response	response	NN
cord-007689-0vpp3xdl	394	16	in	in	IN
cord-007689-0vpp3xdl	394	17	Drosophila	Drosophila	NNP
cord-007689-0vpp3xdl	394	18	adults	adult	NNS
cord-007689-0vpp3xdl	394	19	Inhibition	Inhibition	NNP
cord-007689-0vpp3xdl	394	20	of	of	IN
cord-007689-0vpp3xdl	394	21	HIV-1	HIV-1	NNP
cord-007689-0vpp3xdl	394	22	infection	infection	NN
cord-007689-0vpp3xdl	394	23	by	by	IN
cord-007689-0vpp3xdl	394	24	lentiviral	lentiviral	JJ
cord-007689-0vpp3xdl	394	25	vectors	vector	NNS
cord-007689-0vpp3xdl	394	26	expressing	express	VBG
cord-007689-0vpp3xdl	394	27	Pol	Pol	NNP
cord-007689-0vpp3xdl	394	28	IIIpromoted	iiipromote	VBN
cord-007689-0vpp3xdl	394	29	anti	anti	JJ
cord-007689-0vpp3xdl	394	30	-	-	JJ
cord-007689-0vpp3xdl	394	31	HIV	HIV	NNP
cord-007689-0vpp3xdl	394	32	RNAs	rna	NNS
cord-007689-0vpp3xdl	394	33	Toll	Toll	NNP
cord-007689-0vpp3xdl	394	34	-	-	HYPH
cord-007689-0vpp3xdl	394	35	like	like	JJ
cord-007689-0vpp3xdl	394	36	receptor	receptor	NN
cord-007689-0vpp3xdl	394	37	9-mediated	9-mediated	CD
cord-007689-0vpp3xdl	394	38	recognition	recognition	NN
cord-007689-0vpp3xdl	394	39	of	of	IN
cord-007689-0vpp3xdl	394	40	Herpes	Herpes	NNP
cord-007689-0vpp3xdl	394	41	simplex	simplex	NNP
cord-007689-0vpp3xdl	394	42	virus-2	virus-2	NNP
cord-007689-0vpp3xdl	394	43	by	by	IN
cord-007689-0vpp3xdl	394	44	plasmacytoid	plasmacytoid	NNP
cord-007689-0vpp3xdl	394	45	dendritic	dendritic	NNP
cord-007689-0vpp3xdl	394	46	cells	cell	NNS
cord-007689-0vpp3xdl	394	47	Recognition	Recognition	NNP
cord-007689-0vpp3xdl	394	48	of	of	IN
cord-007689-0vpp3xdl	394	49	single	single	RB
cord-007689-0vpp3xdl	394	50	-	-	HYPH
cord-007689-0vpp3xdl	394	51	stranded	strand	VBN
cord-007689-0vpp3xdl	394	52	RNA	RNA	NNP
cord-007689-0vpp3xdl	394	53	viruses	virus	NNS
cord-007689-0vpp3xdl	394	54	by	by	IN
cord-007689-0vpp3xdl	394	55	Toll	toll	NN
cord-007689-0vpp3xdl	394	56	-	-	HYPH
cord-007689-0vpp3xdl	394	57	like	like	JJ
cord-007689-0vpp3xdl	394	58	receptor	receptor	NN
cord-007689-0vpp3xdl	394	59	7	7	CD
cord-007689-0vpp3xdl	394	60	Potential	potential	JJ
cord-007689-0vpp3xdl	394	61	role	role	NN
cord-007689-0vpp3xdl	394	62	of	of	IN
cord-007689-0vpp3xdl	394	63	PKR	PKR	NNP
cord-007689-0vpp3xdl	394	64	in	in	IN
cord-007689-0vpp3xdl	394	65	double	double	RB
cord-007689-0vpp3xdl	394	66	-	-	HYPH
cord-007689-0vpp3xdl	394	67	stranded	strand	VBN
cord-007689-0vpp3xdl	394	68	RNA	RNA	NNP
cord-007689-0vpp3xdl	394	69	-	-	HYPH
cord-007689-0vpp3xdl	394	70	induced	induce	VBN
cord-007689-0vpp3xdl	394	71	macrophage	macrophage	NN
cord-007689-0vpp3xdl	394	72	activation	activation	NN
cord-007689-0vpp3xdl	394	73	Interactions	interaction	NNS
cord-007689-0vpp3xdl	394	74	between	between	IN
cord-007689-0vpp3xdl	394	75	doublestranded	doublestranded	NNP
cord-007689-0vpp3xdl	394	76	RNA	RNA	NNP
cord-007689-0vpp3xdl	394	77	regulators	regulator	NNS
cord-007689-0vpp3xdl	394	78	and	and	CC
cord-007689-0vpp3xdl	394	79	the	the	DT
cord-007689-0vpp3xdl	394	80	protein	protein	NN
cord-007689-0vpp3xdl	394	81	kinase	kinase	VBZ
cord-007689-0vpp3xdl	394	82	DAI	DAI	NNP
cord-007689-0vpp3xdl	394	83	Differential	differential	JJ
cord-007689-0vpp3xdl	394	84	viral	viral	JJ
cord-007689-0vpp3xdl	394	85	induction	induction	NN
cord-007689-0vpp3xdl	394	86	of	of	IN
cord-007689-0vpp3xdl	394	87	distinct	distinct	JJ
cord-007689-0vpp3xdl	394	88	interferonalpha	interferonalpha	JJ
cord-007689-0vpp3xdl	394	89	genes	gene	NNS
cord-007689-0vpp3xdl	394	90	by	by	IN
cord-007689-0vpp3xdl	394	91	positive	positive	JJ
cord-007689-0vpp3xdl	394	92	feedback	feedback	NN
cord-007689-0vpp3xdl	394	93	through	through	IN
cord-007689-0vpp3xdl	394	94	interferon	interferon	NN
cord-007689-0vpp3xdl	394	95	regulatory	regulatory	JJ
cord-007689-0vpp3xdl	394	96	factor-7	factor-7	NNS
cord-007689-0vpp3xdl	395	1	A	a	DT
cord-007689-0vpp3xdl	395	2	structural	structural	JJ
cord-007689-0vpp3xdl	395	3	basis	basis	NN
cord-007689-0vpp3xdl	395	4	for	for	IN
cord-007689-0vpp3xdl	395	5	discriminating	discriminate	VBG
cord-007689-0vpp3xdl	395	6	between	between	IN
cord-007689-0vpp3xdl	395	7	self	self	NN
cord-007689-0vpp3xdl	395	8	and	and	CC
cord-007689-0vpp3xdl	395	9	nonself	nonself	NN
cord-007689-0vpp3xdl	395	10	double	double	RB
cord-007689-0vpp3xdl	395	11	-	-	HYPH
cord-007689-0vpp3xdl	395	12	stranded	strand	VBN
cord-007689-0vpp3xdl	395	13	RNAs	rna	NNS
cord-007689-0vpp3xdl	395	14	in	in	IN
cord-007689-0vpp3xdl	395	15	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	395	16	cells	cell	NNS
cord-007689-0vpp3xdl	395	17	Subcellular	Subcellular	NNP
cord-007689-0vpp3xdl	395	18	localization	localization	NN
cord-007689-0vpp3xdl	395	19	of	of	IN
cord-007689-0vpp3xdl	395	20	Toll	toll	NN
cord-007689-0vpp3xdl	395	21	-	-	HYPH
cord-007689-0vpp3xdl	395	22	like	like	JJ
cord-007689-0vpp3xdl	395	23	receptor	receptor	NN
cord-007689-0vpp3xdl	395	24	3	3	CD
cord-007689-0vpp3xdl	395	25	in	in	IN
cord-007689-0vpp3xdl	395	26	human	human	JJ
cord-007689-0vpp3xdl	395	27	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	395	28	cells	cell	NNS
cord-007689-0vpp3xdl	396	1	A	a	DT
cord-007689-0vpp3xdl	396	2	human	human	JJ
cord-007689-0vpp3xdl	396	3	homologue	homologue	NN
cord-007689-0vpp3xdl	396	4	of	of	IN
cord-007689-0vpp3xdl	397	1	the	the	DT
cord-007689-0vpp3xdl	397	2	Drosophila	Drosophila	NNP
cord-007689-0vpp3xdl	397	3	Toll	Toll	NNP
cord-007689-0vpp3xdl	397	4	protein	protein	NN
cord-007689-0vpp3xdl	397	5	signals	signal	VBZ
cord-007689-0vpp3xdl	397	6	activation	activation	NN
cord-007689-0vpp3xdl	397	7	of	of	IN
cord-007689-0vpp3xdl	397	8	adaptive	adaptive	JJ
cord-007689-0vpp3xdl	397	9	immunity	immunity	NN
cord-007689-0vpp3xdl	397	10	Activation	Activation	NNP
cord-007689-0vpp3xdl	397	11	of	of	IN
cord-007689-0vpp3xdl	397	12	innate	innate	JJ
cord-007689-0vpp3xdl	397	13	defense	defense	NN
cord-007689-0vpp3xdl	397	14	against	against	IN
cord-007689-0vpp3xdl	397	15	a	a	DT
cord-007689-0vpp3xdl	397	16	paramyxovirus	paramyxovirus	NN
cord-007689-0vpp3xdl	397	17	is	be	VBZ
cord-007689-0vpp3xdl	397	18	mediated	mediate	VBN
cord-007689-0vpp3xdl	397	19	by	by	IN
cord-007689-0vpp3xdl	397	20	RIG	rig	NN
cord-007689-0vpp3xdl	397	21	-	-	:
cord-007689-0vpp3xdl	397	22	I	I	NNP
cord-007689-0vpp3xdl	397	23	and	and	CC
cord-007689-0vpp3xdl	397	24	TLR7	TLR7	NNP
cord-007689-0vpp3xdl	397	25	and	and	CC
cord-007689-0vpp3xdl	397	26	TLR8	TLR8	NNP
cord-007689-0vpp3xdl	397	27	in	in	IN
cord-007689-0vpp3xdl	397	28	a	a	DT
cord-007689-0vpp3xdl	397	29	cell	cell	NN
cord-007689-0vpp3xdl	397	30	-	-	HYPH
cord-007689-0vpp3xdl	397	31	type	type	NN
cord-007689-0vpp3xdl	397	32	-	-	HYPH
cord-007689-0vpp3xdl	397	33	specific	specific	JJ
cord-007689-0vpp3xdl	397	34	manner	manner	JJ
cord-007689-0vpp3xdl	397	35	Cardif	Cardif	NNP
cord-007689-0vpp3xdl	397	36	is	be	VBZ
cord-007689-0vpp3xdl	397	37	an	an	DT
cord-007689-0vpp3xdl	397	38	adaptor	adaptor	NN
cord-007689-0vpp3xdl	397	39	protein	protein	NN
cord-007689-0vpp3xdl	397	40	in	in	IN
cord-007689-0vpp3xdl	397	41	the	the	DT
cord-007689-0vpp3xdl	397	42	RIG	rig	NN
cord-007689-0vpp3xdl	397	43	-	-	:
cord-007689-0vpp3xdl	397	44	I	I	NNP
cord-007689-0vpp3xdl	397	45	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	397	46	pathway	pathway	NN
cord-007689-0vpp3xdl	397	47	and	and	CC
cord-007689-0vpp3xdl	397	48	is	be	VBZ
cord-007689-0vpp3xdl	397	49	targeted	target	VBN
cord-007689-0vpp3xdl	397	50	by	by	IN
cord-007689-0vpp3xdl	397	51	hepatitis	hepatitis	NN
cord-007689-0vpp3xdl	397	52	C	C	NNP
cord-007689-0vpp3xdl	397	53	virus	virus	NN
cord-007689-0vpp3xdl	397	54	Structural	structural	JJ
cord-007689-0vpp3xdl	397	55	requirements	requirement	NNS
cord-007689-0vpp3xdl	397	56	of	of	IN
cord-007689-0vpp3xdl	397	57	doublestranded	doublestranded	NNP
cord-007689-0vpp3xdl	397	58	RNA	RNA	NNP
cord-007689-0vpp3xdl	397	59	for	for	IN
cord-007689-0vpp3xdl	397	60	the	the	DT
cord-007689-0vpp3xdl	397	61	activation	activation	NN
cord-007689-0vpp3xdl	397	62	of	of	IN
cord-007689-0vpp3xdl	397	63	2	2	CD
cord-007689-0vpp3xdl	397	64	'	'	''
cord-007689-0vpp3xdl	397	65	,	,	,
cord-007689-0vpp3xdl	397	66	5'-oligo(A	5'-oligo(a	CD
cord-007689-0vpp3xdl	397	67	)	)	-RRB-
cord-007689-0vpp3xdl	397	68	polymerase	polymerase	NN
cord-007689-0vpp3xdl	397	69	and	and	CC
cord-007689-0vpp3xdl	397	70	protein	protein	NN
cord-007689-0vpp3xdl	397	71	kinase	kinase	NN
cord-007689-0vpp3xdl	397	72	of	of	IN
cord-007689-0vpp3xdl	397	73	interferon	interferon	NN
cord-007689-0vpp3xdl	397	74	-	-	HYPH
cord-007689-0vpp3xdl	397	75	treated	treat	VBN
cord-007689-0vpp3xdl	397	76	HeLa	HeLa	NNP
cord-007689-0vpp3xdl	397	77	cells	cell	NNS
cord-007689-0vpp3xdl	397	78	Replicative	Replicative	NNP
cord-007689-0vpp3xdl	397	79	form	form	NN
cord-007689-0vpp3xdl	397	80	of	of	IN
cord-007689-0vpp3xdl	397	81	encephalomyocarditis	encephalomyocarditis	NNP
cord-007689-0vpp3xdl	397	82	virus	virus	NN
cord-007689-0vpp3xdl	397	83	ribonucleic	ribonucleic	NN
cord-007689-0vpp3xdl	397	84	acid	acid	NN
cord-007689-0vpp3xdl	397	85	TLR	TLR	NNP
cord-007689-0vpp3xdl	397	86	signalling	signal	VBG
cord-007689-0vpp3xdl	397	87	and	and	CC
cord-007689-0vpp3xdl	397	88	activation	activation	NN
cord-007689-0vpp3xdl	397	89	of	of	IN
cord-007689-0vpp3xdl	397	90	IRFs	irfs	NN
cord-007689-0vpp3xdl	397	91	:	:	:
cord-007689-0vpp3xdl	397	92	revisiting	revisit	VBG
cord-007689-0vpp3xdl	397	93	old	old	JJ
cord-007689-0vpp3xdl	397	94	friends	friend	NNS
cord-007689-0vpp3xdl	397	95	from	from	IN
cord-007689-0vpp3xdl	397	96	the	the	DT
cord-007689-0vpp3xdl	397	97	NF	NF	NNP
cord-007689-0vpp3xdl	397	98	-	-	HYPH
cord-007689-0vpp3xdl	397	99	kappaB	kappaB	NNP
cord-007689-0vpp3xdl	397	100	pathway	pathway	NN
cord-007689-0vpp3xdl	397	101	Functional	functional	JJ
cord-007689-0vpp3xdl	397	102	role	role	NN
cord-007689-0vpp3xdl	397	103	of	of	IN
cord-007689-0vpp3xdl	397	104	type	type	NN
cord-007689-0vpp3xdl	397	105	I	-PRON-	PRP
cord-007689-0vpp3xdl	397	106	and	and	CC
cord-007689-0vpp3xdl	397	107	type	type	NN
cord-007689-0vpp3xdl	397	108	II	II	NNP
cord-007689-0vpp3xdl	397	109	interferons	interferon	NNS
cord-007689-0vpp3xdl	397	110	in	in	IN
cord-007689-0vpp3xdl	397	111	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	397	112	defense	defense	NN
cord-007689-0vpp3xdl	397	113	Inhibition	inhibition	NN
cord-007689-0vpp3xdl	397	114	of	of	IN
cord-007689-0vpp3xdl	397	115	vaccinia	vaccinia	NN
cord-007689-0vpp3xdl	397	116	infection	infection	NN
cord-007689-0vpp3xdl	397	117	by	by	IN
cord-007689-0vpp3xdl	397	118	a	a	DT
cord-007689-0vpp3xdl	397	119	liquid	liquid	JJ
cord-007689-0vpp3xdl	397	120	factor	factor	NN
cord-007689-0vpp3xdl	397	121	in	in	IN
cord-007689-0vpp3xdl	397	122	tissues	tissue	NNS
cord-007689-0vpp3xdl	397	123	infected	infect	VBN
cord-007689-0vpp3xdl	397	124	by	by	IN
cord-007689-0vpp3xdl	397	125	homologous	homologous	JJ
cord-007689-0vpp3xdl	397	126	virus	virus	NN
cord-007689-0vpp3xdl	397	127	Orthomyxovirus	Orthomyxovirus	NNP
cord-007689-0vpp3xdl	397	128	replication	replication	NN
cord-007689-0vpp3xdl	397	129	,	,	,
cord-007689-0vpp3xdl	397	130	transcription	transcription	NN
cord-007689-0vpp3xdl	397	131	,	,	,
cord-007689-0vpp3xdl	397	132	and	and	CC
cord-007689-0vpp3xdl	397	133	polyadenylation	polyadenylation	NN
cord-007689-0vpp3xdl	397	134	Critical	critical	JJ
cord-007689-0vpp3xdl	397	135	role	role	NN
cord-007689-0vpp3xdl	397	136	of	of	IN
cord-007689-0vpp3xdl	397	137	TRAF3	traf3	NN
cord-007689-0vpp3xdl	397	138	in	in	IN
cord-007689-0vpp3xdl	397	139	the	the	DT
cord-007689-0vpp3xdl	397	140	Toll	Toll	NNP
cord-007689-0vpp3xdl	397	141	-	-	HYPH
cord-007689-0vpp3xdl	397	142	like	like	JJ
cord-007689-0vpp3xdl	397	143	receptor	receptor	NN
cord-007689-0vpp3xdl	397	144	-	-	HYPH
cord-007689-0vpp3xdl	397	145	dependent	dependent	JJ
cord-007689-0vpp3xdl	397	146	and	and	CC
cord-007689-0vpp3xdl	397	147	-independent	-independent	JJ
cord-007689-0vpp3xdl	397	148	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	397	149	response	response	NN
cord-007689-0vpp3xdl	398	1	Toll	toll	NN
cord-007689-0vpp3xdl	398	2	-	-	HYPH
cord-007689-0vpp3xdl	398	3	like	like	JJ
cord-007689-0vpp3xdl	398	4	receptor	receptor	NN
cord-007689-0vpp3xdl	398	5	-	-	HYPH
cord-007689-0vpp3xdl	398	6	independent	independent	JJ
cord-007689-0vpp3xdl	398	7	gene	gene	NN
cord-007689-0vpp3xdl	398	8	induction	induction	NN
cord-007689-0vpp3xdl	398	9	program	program	NN
cord-007689-0vpp3xdl	398	10	activated	activate	VBN
cord-007689-0vpp3xdl	398	11	by	by	IN
cord-007689-0vpp3xdl	398	12	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	398	13	DNA	dna	NN
cord-007689-0vpp3xdl	398	14	escaped	escape	VBD
cord-007689-0vpp3xdl	398	15	from	from	IN
cord-007689-0vpp3xdl	398	16	apoptotic	apoptotic	JJ
cord-007689-0vpp3xdl	398	17	DNA	dna	NN
cord-007689-0vpp3xdl	398	18	degradation	degradation	NN
cord-007689-0vpp3xdl	398	19	Short	short	JJ
cord-007689-0vpp3xdl	398	20	hairpin	hairpin	NN
cord-007689-0vpp3xdl	398	21	RNAs	rna	NNS
cord-007689-0vpp3xdl	398	22	(	(	-LRB-
cord-007689-0vpp3xdl	398	23	shRNAs	shRNAs	NNP
cord-007689-0vpp3xdl	398	24	)	)	-RRB-
cord-007689-0vpp3xdl	398	25	induce	induce	VB
cord-007689-0vpp3xdl	398	26	sequence	sequence	NN
cord-007689-0vpp3xdl	398	27	-	-	HYPH
cord-007689-0vpp3xdl	398	28	specific	specific	JJ
cord-007689-0vpp3xdl	398	29	silencing	silencing	NN
cord-007689-0vpp3xdl	398	30	in	in	IN
cord-007689-0vpp3xdl	398	31	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	398	32	cells	cell	NNS
cord-007689-0vpp3xdl	398	33	Determinants	determinant	NNS
cord-007689-0vpp3xdl	398	34	of	of	IN
cord-007689-0vpp3xdl	398	35	interferon	interferon	NN
cord-007689-0vpp3xdl	398	36	-	-	HYPH
cord-007689-0vpp3xdl	398	37	stimulated	stimulate	VBN
cord-007689-0vpp3xdl	398	38	gene	gene	NN
cord-007689-0vpp3xdl	398	39	induction	induction	NN
cord-007689-0vpp3xdl	398	40	by	by	IN
cord-007689-0vpp3xdl	398	41	RNAi	RNAi	NNP
cord-007689-0vpp3xdl	398	42	vectors	vectors	NNPS
cord-007689-0vpp3xdl	398	43	RIG	RIG	NNP
cord-007689-0vpp3xdl	398	44	-	-	HYPH
cord-007689-0vpp3xdl	398	45	I	i	NN
cord-007689-0vpp3xdl	398	46	-	-	HYPH
cord-007689-0vpp3xdl	398	47	mediated	mediate	VBN
cord-007689-0vpp3xdl	398	48	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	398	49	responses	response	NNS
cord-007689-0vpp3xdl	398	50	to	to	IN
cord-007689-0vpp3xdl	398	51	single	single	RB
cord-007689-0vpp3xdl	398	52	-	-	HYPH
cord-007689-0vpp3xdl	398	53	stranded	strand	VBN
cord-007689-0vpp3xdl	398	54	RNA	RNA	NNP
cord-007689-0vpp3xdl	398	55	bearing	bear	VBG
cord-007689-0vpp3xdl	398	56	5'-phosphates	5'-phosphates	CD
cord-007689-0vpp3xdl	399	1	Defective	defective	JJ
cord-007689-0vpp3xdl	399	2	LPS	lp	NNS
cord-007689-0vpp3xdl	399	3	signaling	signal	VBG
cord-007689-0vpp3xdl	399	4	in	in	IN
cord-007689-0vpp3xdl	399	5	C3H	c3h	NN
cord-007689-0vpp3xdl	399	6	/	/	SYM
cord-007689-0vpp3xdl	399	7	HeJ	hej	NN
cord-007689-0vpp3xdl	399	8	and	and	CC
cord-007689-0vpp3xdl	399	9	C57BL/10ScCr	c57bl/10sccr	JJ
cord-007689-0vpp3xdl	399	10	mice	mouse	NNS
cord-007689-0vpp3xdl	399	11	:	:	:
cord-007689-0vpp3xdl	400	1	mutations	mutation	NNS
cord-007689-0vpp3xdl	400	2	in	in	IN
cord-007689-0vpp3xdl	400	3	Tlr4	Tlr4	NNP
cord-007689-0vpp3xdl	400	4	gene	gene	NN
cord-007689-0vpp3xdl	401	1	The	the	DT
cord-007689-0vpp3xdl	401	2	RNA	RNA	NNP
cord-007689-0vpp3xdl	401	3	helicase	helicase	NN
cord-007689-0vpp3xdl	401	4	Lgp2	Lgp2	NNP
cord-007689-0vpp3xdl	401	5	inhibits	inhibit	VBZ
cord-007689-0vpp3xdl	401	6	TLRindependent	tlrindependent	NN
cord-007689-0vpp3xdl	401	7	sensing	sensing	NN
cord-007689-0vpp3xdl	401	8	of	of	IN
cord-007689-0vpp3xdl	401	9	viral	viral	JJ
cord-007689-0vpp3xdl	401	10	replication	replication	NN
cord-007689-0vpp3xdl	401	11	by	by	IN
cord-007689-0vpp3xdl	401	12	retinoic	retinoic	JJ
cord-007689-0vpp3xdl	401	13	acid	acid	NN
cord-007689-0vpp3xdl	401	14	-	-	HYPH
cord-007689-0vpp3xdl	401	15	inducible	inducible	JJ
cord-007689-0vpp3xdl	401	16	gene	gene	NN
cord-007689-0vpp3xdl	401	17	-	-	:
cord-007689-0vpp3xdl	401	18	I	I	NNP
cord-007689-0vpp3xdl	401	19	Plasmacytoid	Plasmacytoid	NNP
cord-007689-0vpp3xdl	401	20	dendritic	dendritic	JJ
cord-007689-0vpp3xdl	401	21	cells	cell	NNS
cord-007689-0vpp3xdl	401	22	:	:	:
cord-007689-0vpp3xdl	401	23	the	the	DT
cord-007689-0vpp3xdl	401	24	key	key	NN
cord-007689-0vpp3xdl	401	25	to	to	IN
cord-007689-0vpp3xdl	401	26	CpG	CpG	NNP
cord-007689-0vpp3xdl	402	1	The	the	DT
cord-007689-0vpp3xdl	402	2	RNA	RNA	NNP
cord-007689-0vpp3xdl	402	3	Modification	Modification	NNP
cord-007689-0vpp3xdl	402	4	Database	Database	NNP
cord-007689-0vpp3xdl	402	5	:	:	:
cord-007689-0vpp3xdl	402	6	1999	1999	CD
cord-007689-0vpp3xdl	402	7	update	update	VB
cord-007689-0vpp3xdl	402	8	A	a	DT
cord-007689-0vpp3xdl	402	9	lentivirus	lentivirus	NN
cord-007689-0vpp3xdl	402	10	-	-	HYPH
cord-007689-0vpp3xdl	402	11	based	base	VBN
cord-007689-0vpp3xdl	402	12	system	system	NN
cord-007689-0vpp3xdl	402	13	to	to	TO
cord-007689-0vpp3xdl	402	14	functionally	functionally	RB
cord-007689-0vpp3xdl	402	15	silence	silence	VB
cord-007689-0vpp3xdl	402	16	genes	gene	NNS
cord-007689-0vpp3xdl	402	17	in	in	IN
cord-007689-0vpp3xdl	402	18	primary	primary	JJ
cord-007689-0vpp3xdl	402	19	mammalian	mammalian	JJ
cord-007689-0vpp3xdl	402	20	cells	cell	NNS
cord-007689-0vpp3xdl	402	21	,	,	,
cord-007689-0vpp3xdl	402	22	stem	stem	NN
cord-007689-0vpp3xdl	402	23	cells	cell	NNS
cord-007689-0vpp3xdl	402	24	and	and	CC
cord-007689-0vpp3xdl	402	25	transgenic	transgenic	JJ
cord-007689-0vpp3xdl	402	26	mice	mouse	NNS
cord-007689-0vpp3xdl	402	27	by	by	IN
cord-007689-0vpp3xdl	402	28	RNA	RNA	NNP
cord-007689-0vpp3xdl	402	29	interference	interference	NN
cord-007689-0vpp3xdl	402	30	Deletion	deletion	NN
cord-007689-0vpp3xdl	402	31	of	of	IN
cord-007689-0vpp3xdl	402	32	TLR3	TLR3	NNP
cord-007689-0vpp3xdl	402	33	alters	alter	VBZ
cord-007689-0vpp3xdl	402	34	the	the	DT
cord-007689-0vpp3xdl	402	35	pulmonary	pulmonary	JJ
cord-007689-0vpp3xdl	402	36	immune	immune	JJ
cord-007689-0vpp3xdl	402	37	environment	environment	NN
cord-007689-0vpp3xdl	402	38	and	and	CC
cord-007689-0vpp3xdl	402	39	mucus	mucus	NN
cord-007689-0vpp3xdl	402	40	production	production	NN
cord-007689-0vpp3xdl	402	41	during	during	IN
cord-007689-0vpp3xdl	402	42	respiratory	respiratory	JJ
cord-007689-0vpp3xdl	402	43	syncytial	syncytial	JJ
cord-007689-0vpp3xdl	402	44	virus	virus	NN
cord-007689-0vpp3xdl	402	45	infection	infection	NN
cord-007689-0vpp3xdl	402	46	Positive	positive	JJ
cord-007689-0vpp3xdl	402	47	feedback	feedback	NN
cord-007689-0vpp3xdl	402	48	regulation	regulation	NN
cord-007689-0vpp3xdl	402	49	of	of	IN
cord-007689-0vpp3xdl	402	50	type	type	NN
cord-007689-0vpp3xdl	403	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	403	2	IFN	IFN	NNP
cord-007689-0vpp3xdl	403	3	genes	gene	NNS
cord-007689-0vpp3xdl	403	4	by	by	IN
cord-007689-0vpp3xdl	403	5	the	the	DT
cord-007689-0vpp3xdl	403	6	IFN	IFN	NNP
cord-007689-0vpp3xdl	403	7	-	-	HYPH
cord-007689-0vpp3xdl	403	8	inducible	inducible	JJ
cord-007689-0vpp3xdl	403	9	transcription	transcription	NN
cord-007689-0vpp3xdl	403	10	factor	factor	NN
cord-007689-0vpp3xdl	403	11	IRF-7	IRF-7	NNP
cord-007689-0vpp3xdl	403	12	Toll	Toll	NNP
cord-007689-0vpp3xdl	403	13	-	-	HYPH
cord-007689-0vpp3xdl	403	14	like	like	JJ
cord-007689-0vpp3xdl	403	15	receptor	receptor	NN
cord-007689-0vpp3xdl	403	16	-	-	HYPH
cord-007689-0vpp3xdl	403	17	dependent	dependent	JJ
cord-007689-0vpp3xdl	403	18	activation	activation	NN
cord-007689-0vpp3xdl	403	19	of	of	IN
cord-007689-0vpp3xdl	403	20	several	several	JJ
cord-007689-0vpp3xdl	403	21	human	human	JJ
cord-007689-0vpp3xdl	403	22	blood	blood	NN
cord-007689-0vpp3xdl	403	23	cell	cell	NN
cord-007689-0vpp3xdl	403	24	types	type	NNS
cord-007689-0vpp3xdl	403	25	by	by	IN
cord-007689-0vpp3xdl	403	26	protamine	protamine	NN
cord-007689-0vpp3xdl	403	27	-	-	HYPH
cord-007689-0vpp3xdl	403	28	condensed	condense	VBN
cord-007689-0vpp3xdl	403	29	mRNA	mRNA	NNP
cord-007689-0vpp3xdl	403	30	siRNA	siRNA	NNP
cord-007689-0vpp3xdl	403	31	and	and	CC
cord-007689-0vpp3xdl	404	1	isRNA	isrna	RB
cord-007689-0vpp3xdl	404	2	:	:	:
cord-007689-0vpp3xdl	405	1	two	two	CD
cord-007689-0vpp3xdl	405	2	edges	edge	NNS
cord-007689-0vpp3xdl	405	3	of	of	IN
cord-007689-0vpp3xdl	405	4	one	one	CD
cord-007689-0vpp3xdl	405	5	sword	sword	NN
cord-007689-0vpp3xdl	405	6	Hitching	Hitching	NNP
cord-007689-0vpp3xdl	405	7	RIG	rig	NN
cord-007689-0vpp3xdl	405	8	to	to	IN
cord-007689-0vpp3xdl	405	9	action	action	NN
cord-007689-0vpp3xdl	405	10	Identification	identification	NN
cord-007689-0vpp3xdl	405	11	and	and	CC
cord-007689-0vpp3xdl	405	12	characterization	characterization	NN
cord-007689-0vpp3xdl	405	13	of	of	IN
cord-007689-0vpp3xdl	405	14	MAVS	MAVS	NNPS
cord-007689-0vpp3xdl	405	15	,	,	,
cord-007689-0vpp3xdl	405	16	a	a	DT
cord-007689-0vpp3xdl	405	17	mitochondrial	mitochondrial	JJ
cord-007689-0vpp3xdl	405	18	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	405	19	signaling	signal	VBG
cord-007689-0vpp3xdl	405	20	protein	protein	NN
cord-007689-0vpp3xdl	405	21	that	that	WDT
cord-007689-0vpp3xdl	405	22	activates	activate	VBZ
cord-007689-0vpp3xdl	405	23	NF	NF	NNP
cord-007689-0vpp3xdl	405	24	-	-	HYPH
cord-007689-0vpp3xdl	405	25	kappaB	kappaB	NNP
cord-007689-0vpp3xdl	405	26	and	and	CC
cord-007689-0vpp3xdl	405	27	IRF	IRF	NNP
cord-007689-0vpp3xdl	405	28	3	3	CD
cord-007689-0vpp3xdl	405	29	Triggering	trigger	VBG
cord-007689-0vpp3xdl	405	30	the	the	DT
cord-007689-0vpp3xdl	405	31	interferon	interferon	NN
cord-007689-0vpp3xdl	405	32	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	405	33	response	response	NN
cord-007689-0vpp3xdl	405	34	through	through	IN
cord-007689-0vpp3xdl	405	35	an	an	DT
cord-007689-0vpp3xdl	405	36	IKK	IKK	NNP
cord-007689-0vpp3xdl	405	37	-	-	HYPH
cord-007689-0vpp3xdl	405	38	related	relate	VBN
cord-007689-0vpp3xdl	405	39	pathway	pathway	NN
cord-007689-0vpp3xdl	406	1	The	the	DT
cord-007689-0vpp3xdl	406	2	ends	end	NNS
cord-007689-0vpp3xdl	406	3	of	of	IN
cord-007689-0vpp3xdl	406	4	the	the	DT
cord-007689-0vpp3xdl	406	5	affair	affair	NN
cord-007689-0vpp3xdl	406	6	:	:	:
cord-007689-0vpp3xdl	406	7	capping	capping	NN
cord-007689-0vpp3xdl	406	8	and	and	CC
cord-007689-0vpp3xdl	406	9	polyadenylation	polyadenylation	NN
cord-007689-0vpp3xdl	406	10	Induction	induction	NN
cord-007689-0vpp3xdl	406	11	of	of	IN
cord-007689-0vpp3xdl	406	12	inflammatory	inflammatory	JJ
cord-007689-0vpp3xdl	406	13	cytokines	cytokine	NNS
cord-007689-0vpp3xdl	406	14	and	and	CC
cord-007689-0vpp3xdl	406	15	interferon	interferon	NN
cord-007689-0vpp3xdl	406	16	responses	response	NNS
cord-007689-0vpp3xdl	406	17	by	by	IN
cord-007689-0vpp3xdl	406	18	double	double	RB
cord-007689-0vpp3xdl	406	19	-	-	HYPH
cord-007689-0vpp3xdl	406	20	stranded	stranded	JJ
cord-007689-0vpp3xdl	406	21	and	and	CC
cord-007689-0vpp3xdl	406	22	single	single	RB
cord-007689-0vpp3xdl	406	23	-	-	HYPH
cord-007689-0vpp3xdl	406	24	stranded	strand	VBN
cord-007689-0vpp3xdl	406	25	siRNAs	siRNAs	NNP
cord-007689-0vpp3xdl	406	26	is	be	VBZ
cord-007689-0vpp3xdl	406	27	sequence	sequence	NN
cord-007689-0vpp3xdl	406	28	-	-	HYPH
cord-007689-0vpp3xdl	406	29	dependent	dependent	JJ
cord-007689-0vpp3xdl	406	30	and	and	CC
cord-007689-0vpp3xdl	406	31	requires	require	VBZ
cord-007689-0vpp3xdl	406	32	endosomal	endosomal	NNP
cord-007689-0vpp3xdl	406	33	localization	localization	NN
cord-007689-0vpp3xdl	406	34	Activation	Activation	NNP
cord-007689-0vpp3xdl	406	35	of	of	IN
cord-007689-0vpp3xdl	406	36	the	the	DT
cord-007689-0vpp3xdl	406	37	interferon	interferon	NN
cord-007689-0vpp3xdl	406	38	system	system	NN
cord-007689-0vpp3xdl	406	39	by	by	IN
cord-007689-0vpp3xdl	406	40	short	short	RB
cord-007689-0vpp3xdl	406	41	-	-	HYPH
cord-007689-0vpp3xdl	406	42	interfering	interfere	VBG
cord-007689-0vpp3xdl	406	43	RNAs	rna	NNS
cord-007689-0vpp3xdl	406	44	IRF3	IRF3	NNP
cord-007689-0vpp3xdl	406	45	and	and	CC
cord-007689-0vpp3xdl	406	46	IRF7	IRF7	NNP
cord-007689-0vpp3xdl	406	47	phosphorylation	phosphorylation	NN
cord-007689-0vpp3xdl	406	48	in	in	IN
cord-007689-0vpp3xdl	406	49	virus	virus	NN
cord-007689-0vpp3xdl	406	50	-	-	HYPH
cord-007689-0vpp3xdl	406	51	infected	infect	VBN
cord-007689-0vpp3xdl	406	52	cells	cell	NNS
cord-007689-0vpp3xdl	406	53	does	do	VBZ
cord-007689-0vpp3xdl	406	54	not	not	RB
cord-007689-0vpp3xdl	406	55	require	require	VB
cord-007689-0vpp3xdl	406	56	double	double	RB
cord-007689-0vpp3xdl	406	57	-	-	HYPH
cord-007689-0vpp3xdl	406	58	stranded	strand	VBN
cord-007689-0vpp3xdl	406	59	RNA	rna	NN
cord-007689-0vpp3xdl	406	60	-	-	HYPH
cord-007689-0vpp3xdl	406	61	dependent	dependent	JJ
cord-007689-0vpp3xdl	406	62	protein	protein	NN
cord-007689-0vpp3xdl	406	63	kinase	kinase	NN
cord-007689-0vpp3xdl	406	64	R	r	NN
cord-007689-0vpp3xdl	406	65	or	or	CC
cord-007689-0vpp3xdl	406	66	Ikappa	Ikappa	NNP
cord-007689-0vpp3xdl	406	67	B	B	NNP
cord-007689-0vpp3xdl	406	68	kinase	kinase	NN
cord-007689-0vpp3xdl	406	69	but	but	CC
cord-007689-0vpp3xdl	406	70	is	be	VBZ
cord-007689-0vpp3xdl	406	71	blocked	block	VBN
cord-007689-0vpp3xdl	406	72	by	by	IN
cord-007689-0vpp3xdl	406	73	Vaccinia	Vaccinia	NNP
cord-007689-0vpp3xdl	406	74	virus	virus	NN
cord-007689-0vpp3xdl	406	75	E3L	e3l	NN
cord-007689-0vpp3xdl	406	76	protein	protein	NN
cord-007689-0vpp3xdl	406	77	Recognition	Recognition	NNP
cord-007689-0vpp3xdl	406	78	of	of	IN
cord-007689-0vpp3xdl	406	79	cytosolic	cytosolic	JJ
cord-007689-0vpp3xdl	406	80	DNA	dna	NN
cord-007689-0vpp3xdl	406	81	activates	activate	VBZ
cord-007689-0vpp3xdl	406	82	an	an	DT
cord-007689-0vpp3xdl	406	83	IRF3-dependent	irf3-dependent	NN
cord-007689-0vpp3xdl	406	84	innate	innate	JJ
cord-007689-0vpp3xdl	406	85	immune	immune	JJ
cord-007689-0vpp3xdl	406	86	response	response	NN
cord-007689-0vpp3xdl	406	87	Regulating	regulate	VBG
cord-007689-0vpp3xdl	406	88	intracellular	intracellular	JJ
cord-007689-0vpp3xdl	406	89	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	406	90	defense	defense	NN
cord-007689-0vpp3xdl	406	91	and	and	CC
cord-007689-0vpp3xdl	406	92	permissiveness	permissiveness	NN
cord-007689-0vpp3xdl	406	93	to	to	IN
cord-007689-0vpp3xdl	406	94	hepatitis	hepatitis	NNP
cord-007689-0vpp3xdl	406	95	C	C	NNP
cord-007689-0vpp3xdl	406	96	virus	virus	NN
cord-007689-0vpp3xdl	406	97	RNA	RNA	NNP
cord-007689-0vpp3xdl	406	98	replication	replication	NN
cord-007689-0vpp3xdl	406	99	through	through	IN
cord-007689-0vpp3xdl	406	100	a	a	DT
cord-007689-0vpp3xdl	406	101	cellular	cellular	JJ
cord-007689-0vpp3xdl	406	102	RNA	rna	NN
cord-007689-0vpp3xdl	406	103	helicase	helicase	NN
cord-007689-0vpp3xdl	406	104	,	,	,
cord-007689-0vpp3xdl	406	105	RIG	rig	NN
cord-007689-0vpp3xdl	406	106	-	-	:
cord-007689-0vpp3xdl	406	107	I	I	NNP
cord-007689-0vpp3xdl	406	108	Toll	Toll	NNP
cord-007689-0vpp3xdl	406	109	-	-	HYPH
cord-007689-0vpp3xdl	406	110	like	like	JJ
cord-007689-0vpp3xdl	406	111	receptors	receptor	NNS
cord-007689-0vpp3xdl	406	112	9	9	CD
cord-007689-0vpp3xdl	406	113	and	and	CC
cord-007689-0vpp3xdl	406	114	3	3	CD
cord-007689-0vpp3xdl	406	115	as	as	IN
cord-007689-0vpp3xdl	406	116	essential	essential	JJ
cord-007689-0vpp3xdl	406	117	components	component	NNS
cord-007689-0vpp3xdl	406	118	of	of	IN
cord-007689-0vpp3xdl	406	119	innate	innate	JJ
cord-007689-0vpp3xdl	406	120	immune	immune	JJ
cord-007689-0vpp3xdl	406	121	defense	defense	NN
cord-007689-0vpp3xdl	406	122	against	against	IN
cord-007689-0vpp3xdl	406	123	mouse	mouse	NN
cord-007689-0vpp3xdl	406	124	cytomegalovirus	cytomegalovirus	NNP
cord-007689-0vpp3xdl	406	125	infection	infection	NN
cord-007689-0vpp3xdl	406	126	Type	type	NN
cord-007689-0vpp3xdl	407	1	I	-PRON-	PRP
cord-007689-0vpp3xdl	407	2	interferons	interferon	NNS
cord-007689-0vpp3xdl	407	3	(	(	-LRB-
cord-007689-0vpp3xdl	407	4	alpha/	alpha/	CD
cord-007689-0vpp3xdl	407	5	beta	beta	NN
cord-007689-0vpp3xdl	407	6	)	)	-RRB-
cord-007689-0vpp3xdl	407	7	in	in	IN
cord-007689-0vpp3xdl	407	8	immunity	immunity	NN
cord-007689-0vpp3xdl	407	9	and	and	CC
cord-007689-0vpp3xdl	407	10	autoimmunity	autoimmunity	NN
cord-007689-0vpp3xdl	408	1	A	a	DT
cord-007689-0vpp3xdl	408	2	general	general	JJ
cord-007689-0vpp3xdl	408	3	method	method	NN
cord-007689-0vpp3xdl	408	4	for	for	IN
cord-007689-0vpp3xdl	408	5	gene	gene	NN
cord-007689-0vpp3xdl	408	6	knockdown	knockdown	NN
cord-007689-0vpp3xdl	408	7	in	in	IN
cord-007689-0vpp3xdl	408	8	mice	mouse	NNS
cord-007689-0vpp3xdl	408	9	by	by	IN
cord-007689-0vpp3xdl	408	10	using	use	VBG
cord-007689-0vpp3xdl	408	11	lentiviral	lentiviral	NNP
cord-007689-0vpp3xdl	408	12	vectors	vector	NNS
cord-007689-0vpp3xdl	408	13	expressing	express	VBG
cord-007689-0vpp3xdl	408	14	small	small	JJ
cord-007689-0vpp3xdl	408	15	interfering	interfere	VBG
cord-007689-0vpp3xdl	408	16	RNA	RNA	NNP
cord-007689-0vpp3xdl	408	17	Transcription	Transcription	NNP
cord-007689-0vpp3xdl	408	18	and	and	CC
cord-007689-0vpp3xdl	408	19	replication	replication	NN
cord-007689-0vpp3xdl	408	20	of	of	IN
cord-007689-0vpp3xdl	408	21	nonsegmented	nonsegmente	VBN
cord-007689-0vpp3xdl	408	22	negative	negative	JJ
cord-007689-0vpp3xdl	408	23	-	-	HYPH
cord-007689-0vpp3xdl	408	24	strand	strand	NN
cord-007689-0vpp3xdl	408	25	RNA	RNA	NNP
cord-007689-0vpp3xdl	408	26	viruses	virus	NNS
cord-007689-0vpp3xdl	408	27	Eukaryotic	eukaryotic	JJ
cord-007689-0vpp3xdl	408	28	ribonuclease	ribonuclease	NN
cord-007689-0vpp3xdl	408	29	P	p	NN
cord-007689-0vpp3xdl	408	30	:	:	:
cord-007689-0vpp3xdl	409	1	a	a	DT
cord-007689-0vpp3xdl	409	2	plurality	plurality	NN
cord-007689-0vpp3xdl	409	3	of	of	IN
cord-007689-0vpp3xdl	409	4	ribonucleoprotein	ribonucleoprotein	NN
cord-007689-0vpp3xdl	409	5	enzymes	enzyme	NNS
cord-007689-0vpp3xdl	409	6	VISA	VISA	NNP
cord-007689-0vpp3xdl	409	7	is	be	VBZ
cord-007689-0vpp3xdl	409	8	an	an	DT
cord-007689-0vpp3xdl	409	9	adapter	adapter	NN
cord-007689-0vpp3xdl	409	10	protein	protein	NN
cord-007689-0vpp3xdl	409	11	required	require	VBN
cord-007689-0vpp3xdl	409	12	for	for	IN
cord-007689-0vpp3xdl	409	13	virus	virus	NN
cord-007689-0vpp3xdl	409	14	-	-	HYPH
cord-007689-0vpp3xdl	409	15	triggered	trigger	VBN
cord-007689-0vpp3xdl	409	16	IFN	IFN	NNP
cord-007689-0vpp3xdl	409	17	-	-	HYPH
cord-007689-0vpp3xdl	409	18	beta	beta	NN
cord-007689-0vpp3xdl	409	19	signaling	signal	VBG
cord-007689-0vpp3xdl	409	20	Deficient	deficient	JJ
cord-007689-0vpp3xdl	409	21	signaling	signal	VBG
cord-007689-0vpp3xdl	409	22	in	in	IN
cord-007689-0vpp3xdl	409	23	mice	mice	NN
cord-007689-0vpp3xdl	409	24	devoid	devoid	JJ
cord-007689-0vpp3xdl	409	25	of	of	IN
cord-007689-0vpp3xdl	409	26	double	double	RB
cord-007689-0vpp3xdl	409	27	-	-	HYPH
cord-007689-0vpp3xdl	409	28	stranded	strand	VBN
cord-007689-0vpp3xdl	409	29	RNAdependent	rnadependent	NN
cord-007689-0vpp3xdl	409	30	protein	protein	NN
cord-007689-0vpp3xdl	410	1	kinase	kinase	NNP
cord-007689-0vpp3xdl	410	2	Shared	share	VBN
cord-007689-0vpp3xdl	410	3	and	and	CC
cord-007689-0vpp3xdl	410	4	unique	unique	JJ
cord-007689-0vpp3xdl	410	5	functions	function	NNS
cord-007689-0vpp3xdl	410	6	of	of	IN
cord-007689-0vpp3xdl	410	7	the	the	DT
cord-007689-0vpp3xdl	410	8	DExD	DExD	NNS
cord-007689-0vpp3xdl	410	9	/	/	SYM
cord-007689-0vpp3xdl	410	10	H	h	NN
cord-007689-0vpp3xdl	410	11	-	-	HYPH
cord-007689-0vpp3xdl	410	12	box	box	NN
cord-007689-0vpp3xdl	410	13	helicases	helicase	NNS
cord-007689-0vpp3xdl	410	14	RIG	rig	NN
cord-007689-0vpp3xdl	410	15	-	-	:
cord-007689-0vpp3xdl	410	16	I	I	NNP
cord-007689-0vpp3xdl	410	17	,	,	,
cord-007689-0vpp3xdl	410	18	MDA5	MDA5	NNP
cord-007689-0vpp3xdl	410	19	,	,	,
cord-007689-0vpp3xdl	410	20	and	and	CC
cord-007689-0vpp3xdl	410	21	LGP2	LGP2	NNP
cord-007689-0vpp3xdl	410	22	in	in	IN
cord-007689-0vpp3xdl	410	23	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	410	24	innate	innate	JJ
cord-007689-0vpp3xdl	410	25	immunity	immunity	NN
cord-007689-0vpp3xdl	411	1	The	the	DT
cord-007689-0vpp3xdl	411	2	RNA	RNA	NNP
cord-007689-0vpp3xdl	411	3	helicase	helicase	NN
cord-007689-0vpp3xdl	411	4	RIG	rig	NN
cord-007689-0vpp3xdl	411	5	-	-	:
cord-007689-0vpp3xdl	411	6	I	-PRON-	PRP
cord-007689-0vpp3xdl	411	7	has	have	VBZ
cord-007689-0vpp3xdl	411	8	an	an	DT
cord-007689-0vpp3xdl	411	9	essential	essential	JJ
cord-007689-0vpp3xdl	411	10	function	function	NN
cord-007689-0vpp3xdl	411	11	in	in	IN
cord-007689-0vpp3xdl	411	12	double	double	RB
cord-007689-0vpp3xdl	411	13	-	-	HYPH
cord-007689-0vpp3xdl	411	14	stranded	strand	VBN
cord-007689-0vpp3xdl	411	15	RNA	rna	NN
cord-007689-0vpp3xdl	411	16	-	-	HYPH
cord-007689-0vpp3xdl	411	17	induced	induce	VBN
cord-007689-0vpp3xdl	411	18	innate	innate	JJ
cord-007689-0vpp3xdl	411	19	antiviral	antiviral	JJ
cord-007689-0vpp3xdl	411	20	responses	response	NNS
cord-007689-0vpp3xdl	411	21	Activation	Activation	NNP
cord-007689-0vpp3xdl	411	22	of	of	IN
cord-007689-0vpp3xdl	411	23	the	the	DT
cord-007689-0vpp3xdl	411	24	protein	protein	NN
cord-007689-0vpp3xdl	411	25	kinase	kinase	VBZ
cord-007689-0vpp3xdl	411	26	PKR	PKR	NNP
cord-007689-0vpp3xdl	411	27	by	by	IN
cord-007689-0vpp3xdl	411	28	short	short	JJ
cord-007689-0vpp3xdl	411	29	double	double	RB
cord-007689-0vpp3xdl	411	30	-	-	HYPH
cord-007689-0vpp3xdl	411	31	stranded	stranded	JJ
cord-007689-0vpp3xdl	411	32	RNAs	rna	NNS
cord-007689-0vpp3xdl	411	33	with	with	IN
cord-007689-0vpp3xdl	411	34	single	single	RB
cord-007689-0vpp3xdl	411	35	-	-	HYPH
cord-007689-0vpp3xdl	411	36	stranded	strand	VBN
cord-007689-0vpp3xdl	411	37	tails	tail	NNS
cord-007689-0vpp3xdl	412	1	Interferon	interferon	NN
cord-007689-0vpp3xdl	412	2	action	action	NN
cord-007689-0vpp3xdl	412	3	and	and	CC
cord-007689-0vpp3xdl	412	4	apoptosis	apoptosis	NN
cord-007689-0vpp3xdl	412	5	are	be	VBP
cord-007689-0vpp3xdl	412	6	defective	defective	JJ
cord-007689-0vpp3xdl	412	7	in	in	IN
cord-007689-0vpp3xdl	412	8	mice	mice	NN
cord-007689-0vpp3xdl	412	9	devoid	devoid	JJ
cord-007689-0vpp3xdl	412	10	of	of	IN
cord-007689-0vpp3xdl	412	11	2	2	CD
cord-007689-0vpp3xdl	412	12	'	'	''
cord-007689-0vpp3xdl	412	13	,	,	,
cord-007689-0vpp3xdl	412	14	5'-oligoadenylate	5'-oligoadenylate	CD
cord-007689-0vpp3xdl	412	15	-	-	HYPH
cord-007689-0vpp3xdl	412	16	dependent	dependent	JJ
cord-007689-0vpp3xdl	412	17	RNase	rnase	NN
cord-007689-0vpp3xdl	412	18	L	l	NN
cord-007689-0vpp3xdl	412	19	Isolation	isolation	NN
cord-007689-0vpp3xdl	412	20	of	of	IN
cord-007689-0vpp3xdl	412	21	two	two	CD
cord-007689-0vpp3xdl	412	22	interferon	interferon	NN
cord-007689-0vpp3xdl	412	23	-	-	HYPH
cord-007689-0vpp3xdl	412	24	induced	induce	VBN
cord-007689-0vpp3xdl	412	25	translational	translational	JJ
cord-007689-0vpp3xdl	412	26	inhibitors	inhibitor	NNS
cord-007689-0vpp3xdl	412	27	:	:	:
cord-007689-0vpp3xdl	412	28	a	a	DT
cord-007689-0vpp3xdl	412	29	protein	protein	NN
cord-007689-0vpp3xdl	412	30	kinase	kinase	NN
cord-007689-0vpp3xdl	412	31	and	and	CC
cord-007689-0vpp3xdl	412	32	an	an	DT
cord-007689-0vpp3xdl	412	33	oligo	oligo	JJ
cord-007689-0vpp3xdl	412	34	-	-	HYPH
cord-007689-0vpp3xdl	412	35	isoadenylate	isoadenylate	JJ
cord-007689-0vpp3xdl	412	36	synthetase	synthetase	NN