id	sid	tid	token	lemma	pos
cord-254492-42d77vxf	1	1	key	key	JJ
cord-254492-42d77vxf	1	2	:	:	:
cord-254492-42d77vxf	1	3	cord-254492	cord-254492	NNP
cord-254492-42d77vxf	1	4	-	-	HYPH
cord-254492-42d77vxf	1	5	42d77vxf	42d77vxf	CD
cord-254492-42d77vxf	1	6	authors	author	NNS
cord-254492-42d77vxf	1	7	:	:	:
cord-254492-42d77vxf	1	8	Heaton	Heaton	NNP
cord-254492-42d77vxf	1	9	,	,	,
cord-254492-42d77vxf	1	10	Steven	Steven	NNP
cord-254492-42d77vxf	1	11	M.	M.	NNP
cord-254492-42d77vxf	1	12	;	;	:
cord-254492-42d77vxf	1	13	Borg	Borg	NNP
cord-254492-42d77vxf	1	14	,	,	,
cord-254492-42d77vxf	1	15	Natalie	Natalie	NNP
cord-254492-42d77vxf	1	16	A.	a.	NN
cord-254492-42d77vxf	1	17	;	;	:
cord-254492-42d77vxf	1	18	Dixit	Dixit	NNP
cord-254492-42d77vxf	1	19	,	,	,
cord-254492-42d77vxf	1	20	Vishva	Vishva	NNP
cord-254492-42d77vxf	1	21	M.	M.	NNP
cord-254492-42d77vxf	1	22	title	title	NN
cord-254492-42d77vxf	1	23	:	:	:
cord-254492-42d77vxf	1	24	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	1	25	in	in	IN
cord-254492-42d77vxf	1	26	the	the	DT
cord-254492-42d77vxf	1	27	activation	activation	NN
cord-254492-42d77vxf	1	28	and	and	CC
cord-254492-42d77vxf	1	29	attenuation	attenuation	NN
cord-254492-42d77vxf	1	30	of	of	IN
cord-254492-42d77vxf	1	31	innate	innate	JJ
cord-254492-42d77vxf	1	32	antiviral	antiviral	JJ
cord-254492-42d77vxf	1	33	immunity	immunity	NN
cord-254492-42d77vxf	1	34	date	date	NN
cord-254492-42d77vxf	1	35	:	:	:
cord-254492-42d77vxf	1	36	2016	2016	CD
cord-254492-42d77vxf	1	37	-	-	HYPH
cord-254492-42d77vxf	1	38	01	01	CD
cord-254492-42d77vxf	1	39	-	-	HYPH
cord-254492-42d77vxf	1	40	11	11	CD
cord-254492-42d77vxf	1	41	journal	journal	NN
cord-254492-42d77vxf	1	42	:	:	:
cord-254492-42d77vxf	1	43	J	J	NNP
cord-254492-42d77vxf	1	44	Exp	Exp	NNP
cord-254492-42d77vxf	1	45	Med	Med	NNP
cord-254492-42d77vxf	1	46	DOI	doi	NN
cord-254492-42d77vxf	1	47	:	:	:
cord-254492-42d77vxf	2	1	10.1084	10.1084	LS
cord-254492-42d77vxf	2	2	/	/	SYM
cord-254492-42d77vxf	2	3	jem.20151531	jem.20151531	NNP
cord-254492-42d77vxf	2	4	sha	sha	NNP
cord-254492-42d77vxf	3	1	:	:	:
cord-254492-42d77vxf	3	2	dd4ce30ff12f64b4cc7327406db2d77e5a9a66b9	dd4ce30ff12f64b4cc7327406db2d77e5a9a66b9	NNP
cord-254492-42d77vxf	3	3	doc_id	doc_id	NNPS
cord-254492-42d77vxf	3	4	:	:	:
cord-254492-42d77vxf	3	5	254492	254492	CD
cord-254492-42d77vxf	3	6	cord_uid	cord_uid	NNS
cord-254492-42d77vxf	3	7	:	:	:
cord-254492-42d77vxf	4	1	42d77vxf	42d77vxf	CD
cord-254492-42d77vxf	5	1	Viral	viral	JJ
cord-254492-42d77vxf	5	2	infection	infection	NN
cord-254492-42d77vxf	5	3	activates	activate	VBZ
cord-254492-42d77vxf	5	4	danger	danger	NN
cord-254492-42d77vxf	5	5	signals	signal	NNS
cord-254492-42d77vxf	5	6	that	that	WDT
cord-254492-42d77vxf	5	7	are	be	VBP
cord-254492-42d77vxf	5	8	transmitted	transmit	VBN
cord-254492-42d77vxf	5	9	via	via	IN
cord-254492-42d77vxf	5	10	the	the	DT
cord-254492-42d77vxf	5	11	retinoic	retinoic	JJ
cord-254492-42d77vxf	5	12	acid	acid	NN
cord-254492-42d77vxf	5	13	–	–	:
cord-254492-42d77vxf	5	14	inducible	inducible	JJ
cord-254492-42d77vxf	5	15	gene	gene	NN
cord-254492-42d77vxf	5	16	1–like	1–like	CD
cord-254492-42d77vxf	5	17	receptor	receptor	NN
cord-254492-42d77vxf	5	18	(	(	-LRB-
cord-254492-42d77vxf	5	19	RLR	RLR	NNP
cord-254492-42d77vxf	5	20	)	)	-RRB-
cord-254492-42d77vxf	5	21	,	,	,
cord-254492-42d77vxf	5	22	nucleotide	nucleotide	NN
cord-254492-42d77vxf	5	23	-	-	HYPH
cord-254492-42d77vxf	5	24	binding	bind	VBG
cord-254492-42d77vxf	5	25	oligomerization	oligomerization	NN
cord-254492-42d77vxf	5	26	domain	domain	NN
cord-254492-42d77vxf	5	27	-	-	HYPH
cord-254492-42d77vxf	5	28	like	like	JJ
cord-254492-42d77vxf	5	29	receptor	receptor	NN
cord-254492-42d77vxf	5	30	(	(	-LRB-
cord-254492-42d77vxf	5	31	NLR	NLR	NNP
cord-254492-42d77vxf	5	32	)	)	-RRB-
cord-254492-42d77vxf	5	33	,	,	,
cord-254492-42d77vxf	5	34	and	and	CC
cord-254492-42d77vxf	5	35	Toll	toll	NN
cord-254492-42d77vxf	5	36	-	-	HYPH
cord-254492-42d77vxf	5	37	like	like	JJ
cord-254492-42d77vxf	5	38	receptor	receptor	NN
cord-254492-42d77vxf	5	39	(	(	-LRB-
cord-254492-42d77vxf	5	40	TLR	TLR	NNP
cord-254492-42d77vxf	5	41	)	)	-RRB-
cord-254492-42d77vxf	5	42	protein	protein	NN
cord-254492-42d77vxf	5	43	signaling	signal	VBG
cord-254492-42d77vxf	5	44	cascades	cascade	NNS
cord-254492-42d77vxf	5	45	.	.	.
cord-254492-42d77vxf	6	1	This	this	DT
cord-254492-42d77vxf	6	2	places	place	NNS
cord-254492-42d77vxf	6	3	host	host	NN
cord-254492-42d77vxf	6	4	cells	cell	NNS
cord-254492-42d77vxf	6	5	in	in	IN
cord-254492-42d77vxf	6	6	an	an	DT
cord-254492-42d77vxf	6	7	antiviral	antiviral	JJ
cord-254492-42d77vxf	6	8	posture	posture	NN
cord-254492-42d77vxf	6	9	by	by	IN
cord-254492-42d77vxf	6	10	up	up	IN
cord-254492-42d77vxf	6	11	-	-	HYPH
cord-254492-42d77vxf	6	12	regulating	regulate	VBG
cord-254492-42d77vxf	6	13	antiviral	antiviral	JJ
cord-254492-42d77vxf	6	14	cytokines	cytokine	NNS
cord-254492-42d77vxf	6	15	including	include	VBG
cord-254492-42d77vxf	6	16	type	type	NN
cord-254492-42d77vxf	6	17	-	-	:
cord-254492-42d77vxf	6	18	I	-PRON-	PRP
cord-254492-42d77vxf	6	19	interferon	interferon	NN
cord-254492-42d77vxf	6	20	(	(	-LRB-
cord-254492-42d77vxf	6	21	IFN	IFN	NNP
cord-254492-42d77vxf	6	22	-	-	HYPH
cord-254492-42d77vxf	6	23	I	I	NNP
cord-254492-42d77vxf	6	24	)	)	-RRB-
cord-254492-42d77vxf	6	25	.	.	.
cord-254492-42d77vxf	7	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	7	2	modifications	modification	NNS
cord-254492-42d77vxf	7	3	and	and	CC
cord-254492-42d77vxf	7	4	cross	cross	NN
cord-254492-42d77vxf	7	5	-	-	NN
cord-254492-42d77vxf	7	6	talk	talk	NN
cord-254492-42d77vxf	7	7	between	between	IN
cord-254492-42d77vxf	7	8	proteins	protein	NNS
cord-254492-42d77vxf	7	9	within	within	IN
cord-254492-42d77vxf	7	10	these	these	DT
cord-254492-42d77vxf	7	11	signaling	signal	VBG
cord-254492-42d77vxf	7	12	cascades	cascade	NNS
cord-254492-42d77vxf	7	13	potentiate	potentiate	VBP
cord-254492-42d77vxf	7	14	IFN	IFN	NNP
cord-254492-42d77vxf	7	15	-	-	HYPH
cord-254492-42d77vxf	7	16	I	-PRON-	PRP
cord-254492-42d77vxf	7	17	expression	expression	NN
cord-254492-42d77vxf	7	18	,	,	,
cord-254492-42d77vxf	7	19	and	and	CC
cord-254492-42d77vxf	7	20	inversely	inversely	RB
cord-254492-42d77vxf	7	21	,	,	,
cord-254492-42d77vxf	7	22	a	a	DT
cord-254492-42d77vxf	7	23	growing	grow	VBG
cord-254492-42d77vxf	7	24	number	number	NN
cord-254492-42d77vxf	7	25	of	of	IN
cord-254492-42d77vxf	7	26	viruses	virus	NNS
cord-254492-42d77vxf	7	27	are	be	VBP
cord-254492-42d77vxf	7	28	found	find	VBN
cord-254492-42d77vxf	7	29	to	to	TO
cord-254492-42d77vxf	7	30	weaponize	weaponize	VB
cord-254492-42d77vxf	7	31	the	the	DT
cord-254492-42d77vxf	7	32	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	7	33	modification	modification	NN
cord-254492-42d77vxf	7	34	system	system	NN
cord-254492-42d77vxf	7	35	to	to	TO
cord-254492-42d77vxf	7	36	suppress	suppress	VB
cord-254492-42d77vxf	7	37	IFN	IFN	NNP
cord-254492-42d77vxf	7	38	-	-	HYPH
cord-254492-42d77vxf	7	39	I.	I.	NNP
cord-254492-42d77vxf	8	1	Here	here	RB
cord-254492-42d77vxf	8	2	we	-PRON-	PRP
cord-254492-42d77vxf	8	3	review	review	VBP
cord-254492-42d77vxf	8	4	how	how	WRB
cord-254492-42d77vxf	8	5	host-	host-	NN
cord-254492-42d77vxf	8	6	and	and	CC
cord-254492-42d77vxf	8	7	virus	virus	NN
cord-254492-42d77vxf	8	8	-	-	HYPH
cord-254492-42d77vxf	8	9	directed	direct	VBN
cord-254492-42d77vxf	8	10	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	8	11	modification	modification	NN
cord-254492-42d77vxf	8	12	of	of	IN
cord-254492-42d77vxf	8	13	proteins	protein	NNS
cord-254492-42d77vxf	8	14	in	in	IN
cord-254492-42d77vxf	8	15	the	the	DT
cord-254492-42d77vxf	8	16	RLR	RLR	NNP
cord-254492-42d77vxf	8	17	,	,	,
cord-254492-42d77vxf	8	18	NLR	NLR	NNP
cord-254492-42d77vxf	8	19	,	,	,
cord-254492-42d77vxf	8	20	and	and	CC
cord-254492-42d77vxf	8	21	TLR	TLR	NNP
cord-254492-42d77vxf	8	22	antiviral	antiviral	JJ
cord-254492-42d77vxf	8	23	signaling	signaling	NN
cord-254492-42d77vxf	8	24	cascades	cascade	NNS
cord-254492-42d77vxf	8	25	modulate	modulate	VBP
cord-254492-42d77vxf	8	26	IFN	IFN	NNP
cord-254492-42d77vxf	8	27	-	-	HYPH
cord-254492-42d77vxf	8	28	I	-PRON-	PRP
cord-254492-42d77vxf	8	29	expression	expression	NN
cord-254492-42d77vxf	8	30	.	.	.
cord-254492-42d77vxf	9	1	The	the	DT
cord-254492-42d77vxf	9	2	frontline	frontline	NN
cord-254492-42d77vxf	9	3	in	in	IN
cord-254492-42d77vxf	9	4	the	the	DT
cord-254492-42d77vxf	9	5	cellular	cellular	JJ
cord-254492-42d77vxf	9	6	response	response	NN
cord-254492-42d77vxf	9	7	to	to	IN
cord-254492-42d77vxf	9	8	viral	viral	JJ
cord-254492-42d77vxf	9	9	infection	infection	NN
cord-254492-42d77vxf	9	10	is	be	VBZ
cord-254492-42d77vxf	9	11	comprised	comprise	VBN
cord-254492-42d77vxf	9	12	of	of	IN
cord-254492-42d77vxf	9	13	the	the	DT
cord-254492-42d77vxf	9	14	specific	specific	JJ
cord-254492-42d77vxf	9	15	and	and	CC
cord-254492-42d77vxf	9	16	general	general	JJ
cord-254492-42d77vxf	9	17	effectors	effector	NNS
cord-254492-42d77vxf	9	18	of	of	IN
cord-254492-42d77vxf	9	19	the	the	DT
cord-254492-42d77vxf	9	20	innate	innate	JJ
cord-254492-42d77vxf	9	21	immune	immune	JJ
cord-254492-42d77vxf	9	22	system	system	NN
cord-254492-42d77vxf	9	23	.	.	.
cord-254492-42d77vxf	10	1	Effector	effector	NN
cord-254492-42d77vxf	10	2	molecule	molecule	NN
cord-254492-42d77vxf	10	3	production	production	NN
cord-254492-42d77vxf	10	4	is	be	VBZ
cord-254492-42d77vxf	10	5	initiated	initiate	VBN
cord-254492-42d77vxf	10	6	by	by	IN
cord-254492-42d77vxf	10	7	immune	immune	JJ
cord-254492-42d77vxf	10	8	sentinels	sentinel	NNS
cord-254492-42d77vxf	10	9	known	know	VBN
cord-254492-42d77vxf	10	10	as	as	IN
cord-254492-42d77vxf	10	11	pattern	pattern	NN
cord-254492-42d77vxf	10	12	recognition	recognition	NN
cord-254492-42d77vxf	10	13	receptors	receptor	NNS
cord-254492-42d77vxf	10	14	(	(	-LRB-
cord-254492-42d77vxf	10	15	PRRs	PRRs	NNP
cord-254492-42d77vxf	10	16	)	)	-RRB-
cord-254492-42d77vxf	10	17	,	,	,
cord-254492-42d77vxf	10	18	which	which	WDT
cord-254492-42d77vxf	10	19	screen	screen	VBP
cord-254492-42d77vxf	10	20	the	the	DT
cord-254492-42d77vxf	10	21	intra	intra	JJ
cord-254492-42d77vxf	10	22	-	-	JJ
cord-254492-42d77vxf	10	23	and	and	CC
cord-254492-42d77vxf	10	24	extracellular	extracellular	JJ
cord-254492-42d77vxf	10	25	environment	environment	NN
cord-254492-42d77vxf	10	26	for	for	IN
cord-254492-42d77vxf	10	27	molecular	molecular	JJ
cord-254492-42d77vxf	10	28	motifs	motif	NNS
cord-254492-42d77vxf	10	29	uniquely	uniquely	RB
cord-254492-42d77vxf	10	30	associated	associate	VBN
cord-254492-42d77vxf	10	31	with	with	IN
cord-254492-42d77vxf	10	32	pathogens	pathogen	NNS
cord-254492-42d77vxf	10	33	.	.	.
cord-254492-42d77vxf	11	1	PRR	PRR	NNP
cord-254492-42d77vxf	11	2	engagement	engagement	NN
cord-254492-42d77vxf	11	3	transduces	transduce	VBZ
cord-254492-42d77vxf	11	4	pro	pro	JJ
cord-254492-42d77vxf	11	5	-	-	JJ
cord-254492-42d77vxf	11	6	immune	immune	JJ
cord-254492-42d77vxf	11	7	signals	signal	NNS
cord-254492-42d77vxf	11	8	into	into	IN
cord-254492-42d77vxf	11	9	the	the	DT
cord-254492-42d77vxf	11	10	nucleus	nucleus	NN
cord-254492-42d77vxf	11	11	via	via	IN
cord-254492-42d77vxf	11	12	protein	protein	NN
cord-254492-42d77vxf	11	13	signaling	signal	VBG
cord-254492-42d77vxf	11	14	cascades	cascade	NNS
cord-254492-42d77vxf	11	15	that	that	IN
cord-254492-42d77vxf	11	16	self	self	NN
cord-254492-42d77vxf	11	17	-	-	HYPH
cord-254492-42d77vxf	11	18	limit	limit	NN
cord-254492-42d77vxf	11	19	to	to	TO
cord-254492-42d77vxf	11	20	mitigate	mitigate	VB
cord-254492-42d77vxf	11	21	autoimmunity	autoimmunity	NN
cord-254492-42d77vxf	11	22	as	as	IN
cord-254492-42d77vxf	11	23	the	the	DT
cord-254492-42d77vxf	11	24	infection	infection	NN
cord-254492-42d77vxf	11	25	clears	clear	VBZ
cord-254492-42d77vxf	11	26	(	(	-LRB-
cord-254492-42d77vxf	11	27	Crampton	Crampton	NNP
cord-254492-42d77vxf	11	28	et	et	NNP
cord-254492-42d77vxf	11	29	al	al	NNP
cord-254492-42d77vxf	11	30	.	.	NNP
cord-254492-42d77vxf	11	31	,	,	,
cord-254492-42d77vxf	11	32	2012	2012	CD
cord-254492-42d77vxf	11	33	)	)	-RRB-
cord-254492-42d77vxf	11	34	.	.	.
cord-254492-42d77vxf	12	1	Protein	protein	NN
cord-254492-42d77vxf	12	2	posttranslational	posttranslational	JJ
cord-254492-42d77vxf	12	3	modifications	modification	NNS
cord-254492-42d77vxf	12	4	(	(	-LRB-
cord-254492-42d77vxf	12	5	PTMs	ptm	NNS
cord-254492-42d77vxf	12	6	)	)	-RRB-
cord-254492-42d77vxf	12	7	form	form	VBP
cord-254492-42d77vxf	12	8	part	part	NN
cord-254492-42d77vxf	12	9	of	of	IN
cord-254492-42d77vxf	12	10	this	this	DT
cord-254492-42d77vxf	12	11	exquisite	exquisite	JJ
cord-254492-42d77vxf	12	12	system	system	NN
cord-254492-42d77vxf	12	13	of	of	IN
cord-254492-42d77vxf	12	14	regulation	regulation	NN
cord-254492-42d77vxf	12	15	,	,	,
cord-254492-42d77vxf	12	16	with	with	IN
cord-254492-42d77vxf	12	17	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	12	18	and	and	CC
cord-254492-42d77vxf	12	19	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	12	20	-	-	HYPH
cord-254492-42d77vxf	12	21	like	like	JJ
cord-254492-42d77vxf	12	22	modifications	modification	NNS
cord-254492-42d77vxf	12	23	key	key	JJ
cord-254492-42d77vxf	12	24	among	among	IN
cord-254492-42d77vxf	12	25	them	-PRON-	PRP
cord-254492-42d77vxf	12	26	.	.	.
cord-254492-42d77vxf	13	1	The	the	DT
cord-254492-42d77vxf	13	2	retinoic	retinoic	JJ
cord-254492-42d77vxf	13	3	acid	acid	NN
cord-254492-42d77vxf	13	4	-	-	HYPH
cord-254492-42d77vxf	13	5	inducible	inducible	JJ
cord-254492-42d77vxf	13	6	gene	gene	NN
cord-254492-42d77vxf	13	7	1	1	CD
cord-254492-42d77vxf	13	8	(	(	-LRB-
cord-254492-42d77vxf	13	9	RIG	RIG	NNP
cord-254492-42d77vxf	13	10	-	-	HYPH
cord-254492-42d77vxf	13	11	I)-like	I)-like	NNP
cord-254492-42d77vxf	13	12	receptors	receptor	NNS
cord-254492-42d77vxf	13	13	(	(	-LRB-
cord-254492-42d77vxf	13	14	RLRs	rlr	NNS
cord-254492-42d77vxf	13	15	)	)	-RRB-
cord-254492-42d77vxf	13	16	and	and	CC
cord-254492-42d77vxf	13	17	nucleotide	nucleotide	NN
cord-254492-42d77vxf	13	18	-	-	HYPH
cord-254492-42d77vxf	13	19	binding	bind	VBG
cord-254492-42d77vxf	13	20	oligomerization	oligomerization	NN
cord-254492-42d77vxf	13	21	domain	domain	NN
cord-254492-42d77vxf	13	22	(	(	-LRB-
cord-254492-42d77vxf	13	23	NOD)-like	nod)-like	CD
cord-254492-42d77vxf	13	24	receptors	receptor	NNS
cord-254492-42d77vxf	13	25	(	(	-LRB-
cord-254492-42d77vxf	13	26	NLRs	nlr	NNS
cord-254492-42d77vxf	13	27	)	)	-RRB-
cord-254492-42d77vxf	13	28	are	be	VBP
cord-254492-42d77vxf	13	29	intracellular	intracellular	JJ
cord-254492-42d77vxf	13	30	PRRs	prr	NNS
cord-254492-42d77vxf	13	31	.	.	.
cord-254492-42d77vxf	14	1	The	the	DT
cord-254492-42d77vxf	14	2	RLRs	rlr	NNS
cord-254492-42d77vxf	14	3	sense	sense	VBP
cord-254492-42d77vxf	14	4	invasive	invasive	JJ
cord-254492-42d77vxf	14	5	RNA	RNA	NNP
cord-254492-42d77vxf	14	6	produced	produce	VBN
cord-254492-42d77vxf	14	7	during	during	IN
cord-254492-42d77vxf	14	8	infection	infection	NN
cord-254492-42d77vxf	14	9	by	by	IN
cord-254492-42d77vxf	14	10	both	both	DT
cord-254492-42d77vxf	14	11	RNA	RNA	NNP
cord-254492-42d77vxf	14	12	and	and	CC
cord-254492-42d77vxf	14	13	DNA	dna	NN
cord-254492-42d77vxf	14	14	viruses	virus	NNS
cord-254492-42d77vxf	14	15	(	(	-LRB-
cord-254492-42d77vxf	14	16	Schlee	Schlee	NNP
cord-254492-42d77vxf	14	17	,	,	,
cord-254492-42d77vxf	14	18	2013	2013	CD
cord-254492-42d77vxf	14	19	)	)	-RRB-
cord-254492-42d77vxf	14	20	.	.	.
cord-254492-42d77vxf	15	1	RLR	RLR	NNP
cord-254492-42d77vxf	15	2	engagement	engagement	NN
cord-254492-42d77vxf	15	3	up	up	RB
cord-254492-42d77vxf	15	4	-	-	HYPH
cord-254492-42d77vxf	15	5	regulates	regulate	NNS
cord-254492-42d77vxf	15	6	type	type	NN
cord-254492-42d77vxf	15	7	-	-	:
cord-254492-42d77vxf	15	8	I	-PRON-	PRP
cord-254492-42d77vxf	15	9	IFN	IFN	NNP
cord-254492-42d77vxf	15	10	(	(	-LRB-
cord-254492-42d77vxf	15	11	IFN	IFN	NNP
cord-254492-42d77vxf	15	12	-	-	HYPH
cord-254492-42d77vxf	15	13	I	I	NNP
cord-254492-42d77vxf	15	14	)	)	-RRB-
cord-254492-42d77vxf	15	15	expression	expression	NN
cord-254492-42d77vxf	15	16	,	,	,
cord-254492-42d77vxf	15	17	which	which	WDT
cord-254492-42d77vxf	15	18	in	in	IN
cord-254492-42d77vxf	15	19	turn	turn	NN
cord-254492-42d77vxf	15	20	stimulates	stimulate	VBZ
cord-254492-42d77vxf	15	21	transcription	transcription	NN
cord-254492-42d77vxf	15	22	of	of	IN
cord-254492-42d77vxf	15	23	hundreds	hundred	NNS
cord-254492-42d77vxf	15	24	of	of	IN
cord-254492-42d77vxf	15	25	IFN	IFN	NNP
cord-254492-42d77vxf	15	26	-	-	HYPH
cord-254492-42d77vxf	15	27	stimulated	stimulate	VBN
cord-254492-42d77vxf	15	28	genes	gene	NNS
cord-254492-42d77vxf	15	29	(	(	-LRB-
cord-254492-42d77vxf	15	30	ISGs	ISGs	NNP
cord-254492-42d77vxf	15	31	)	)	-RRB-
cord-254492-42d77vxf	15	32	that	that	WDT
cord-254492-42d77vxf	15	33	commit	commit	VBP
cord-254492-42d77vxf	15	34	host	host	NN
cord-254492-42d77vxf	15	35	and	and	CC
cord-254492-42d77vxf	15	36	nearby	nearby	JJ
cord-254492-42d77vxf	15	37	cells	cell	NNS
cord-254492-42d77vxf	15	38	to	to	IN
cord-254492-42d77vxf	15	39	an	an	DT
cord-254492-42d77vxf	15	40	antiviral	antiviral	JJ
cord-254492-42d77vxf	15	41	posture	posture	NN
cord-254492-42d77vxf	15	42	.	.	.
cord-254492-42d77vxf	16	1	Recognized	recognize	VBN
cord-254492-42d77vxf	16	2	for	for	IN
cord-254492-42d77vxf	16	3	their	-PRON-	PRP$
cord-254492-42d77vxf	16	4	role	role	NN
cord-254492-42d77vxf	16	5	in	in	IN
cord-254492-42d77vxf	16	6	antibacterial	antibacterial	JJ
cord-254492-42d77vxf	16	7	immunity	immunity	NN
cord-254492-42d77vxf	16	8	,	,	,
cord-254492-42d77vxf	16	9	the	the	DT
cord-254492-42d77vxf	16	10	NLRs	nlr	NNS
cord-254492-42d77vxf	16	11	are	be	VBP
cord-254492-42d77vxf	16	12	emerging	emerge	VBG
cord-254492-42d77vxf	16	13	as	as	IN
cord-254492-42d77vxf	16	14	antiviral	antiviral	JJ
cord-254492-42d77vxf	16	15	mediators	mediator	NNS
cord-254492-42d77vxf	16	16	that	that	WDT
cord-254492-42d77vxf	16	17	regulate	regulate	VBP
cord-254492-42d77vxf	16	18	both	both	CC
cord-254492-42d77vxf	16	19	IFN	IFN	NNP
cord-254492-42d77vxf	16	20	-	-	HYPH
cord-254492-42d77vxf	16	21	I	I	NNP
cord-254492-42d77vxf	16	22	and	and	CC
cord-254492-42d77vxf	16	23	NF	NF	NNP
cord-254492-42d77vxf	16	24	-	-	HYPH
cord-254492-42d77vxf	16	25	κB	κb	CD
cord-254492-42d77vxf	16	26	activation	activation	NN
cord-254492-42d77vxf	16	27	.	.	.
cord-254492-42d77vxf	17	1	These	these	DT
cord-254492-42d77vxf	17	2	are	be	VBP
cord-254492-42d77vxf	17	3	also	also	RB
cord-254492-42d77vxf	17	4	activated	activate	VBN
cord-254492-42d77vxf	17	5	by	by	IN
cord-254492-42d77vxf	17	6	TLRs	TLRs	NNP
cord-254492-42d77vxf	17	7	,	,	,
cord-254492-42d77vxf	17	8	a	a	DT
cord-254492-42d77vxf	17	9	cell	cell	NN
cord-254492-42d77vxf	17	10	-	-	HYPH
cord-254492-42d77vxf	17	11	specific	specific	JJ
cord-254492-42d77vxf	17	12	class	class	NN
cord-254492-42d77vxf	17	13	of	of	IN
cord-254492-42d77vxf	17	14	extracellular	extracellular	JJ
cord-254492-42d77vxf	17	15	and	and	CC
cord-254492-42d77vxf	17	16	endosomal	endosomal	NNP
cord-254492-42d77vxf	17	17	transmembrane	transmembrane	NNP
cord-254492-42d77vxf	17	18	PRRs	PRRs	NNP
cord-254492-42d77vxf	17	19	that	that	WDT
cord-254492-42d77vxf	17	20	sense	sense	VBP
cord-254492-42d77vxf	17	21	a	a	DT
cord-254492-42d77vxf	17	22	broad	broad	JJ
cord-254492-42d77vxf	17	23	spectrum	spectrum	NN
cord-254492-42d77vxf	17	24	of	of	IN
cord-254492-42d77vxf	17	25	pathogenic	pathogenic	JJ
cord-254492-42d77vxf	17	26	motifs	motif	NNS
cord-254492-42d77vxf	17	27	.	.	.
cord-254492-42d77vxf	18	1	RLR	RLR	NNP
cord-254492-42d77vxf	18	2	,	,	,
cord-254492-42d77vxf	18	3	NLR	NLR	NNP
cord-254492-42d77vxf	18	4	,	,	,
cord-254492-42d77vxf	18	5	and	and	CC
cord-254492-42d77vxf	18	6	TLR	TLR	NNP
cord-254492-42d77vxf	18	7	signaling	signal	VBG
cord-254492-42d77vxf	18	8	proteins	protein	NNS
cord-254492-42d77vxf	18	9	must	must	MD
cord-254492-42d77vxf	18	10	be	be	VB
cord-254492-42d77vxf	18	11	spatially	spatially	RB
cord-254492-42d77vxf	18	12	and	and	CC
cord-254492-42d77vxf	18	13	temporally	temporally	RB
cord-254492-42d77vxf	18	14	coordinated	coordinated	JJ
cord-254492-42d77vxf	18	15	for	for	IN
cord-254492-42d77vxf	18	16	efficient	efficient	JJ
cord-254492-42d77vxf	18	17	immune	immune	JJ
cord-254492-42d77vxf	18	18	signal	signal	NN
cord-254492-42d77vxf	18	19	transduction	transduction	NN
cord-254492-42d77vxf	18	20	.	.	.
cord-254492-42d77vxf	19	1	Ubiquitination	Ubiquitination	NNP
cord-254492-42d77vxf	19	2	is	be	VBZ
cord-254492-42d77vxf	19	3	a	a	DT
cord-254492-42d77vxf	19	4	PTM	PTM	NNP
cord-254492-42d77vxf	19	5	involving	involve	VBG
cord-254492-42d77vxf	19	6	the	the	DT
cord-254492-42d77vxf	19	7	covalent	covalent	JJ
cord-254492-42d77vxf	19	8	attachment	attachment	NN
cord-254492-42d77vxf	19	9	of	of	IN
cord-254492-42d77vxf	19	10	the	the	DT
cord-254492-42d77vxf	19	11	8.6-kD	8.6-kd	CD
cord-254492-42d77vxf	19	12	protein	protein	NN
cord-254492-42d77vxf	19	13	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	19	14	to	to	TO
cord-254492-42d77vxf	19	15	target	target	VB
cord-254492-42d77vxf	19	16	proteins	protein	NNS
cord-254492-42d77vxf	19	17	.	.	.
cord-254492-42d77vxf	20	1	Ubiquitination	Ubiquitination	NNP
cord-254492-42d77vxf	20	2	is	be	VBZ
cord-254492-42d77vxf	20	3	catalyzed	catalyze	VBN
cord-254492-42d77vxf	20	4	by	by	IN
cord-254492-42d77vxf	20	5	the	the	DT
cord-254492-42d77vxf	20	6	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	20	7	-	-	HYPH
cord-254492-42d77vxf	20	8	activating	activate	VBG
cord-254492-42d77vxf	20	9	enzyme	enzyme	NN
cord-254492-42d77vxf	20	10	(	(	-LRB-
cord-254492-42d77vxf	20	11	E1	E1	NNP
cord-254492-42d77vxf	20	12	)	)	-RRB-
cord-254492-42d77vxf	20	13	,	,	,
cord-254492-42d77vxf	20	14	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	20	15	-	-	HYPH
cord-254492-42d77vxf	20	16	conjugating	conjugate	VBG
cord-254492-42d77vxf	20	17	enzyme	enzyme	NN
cord-254492-42d77vxf	20	18	(	(	-LRB-
cord-254492-42d77vxf	20	19	E2	E2	NNP
cord-254492-42d77vxf	20	20	)	)	-RRB-
cord-254492-42d77vxf	20	21	,	,	,
cord-254492-42d77vxf	20	22	and	and	CC
cord-254492-42d77vxf	20	23	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	20	24	protein	protein	NN
cord-254492-42d77vxf	20	25	ligase	ligase	NN
cord-254492-42d77vxf	20	26	(	(	-LRB-
cord-254492-42d77vxf	20	27	E3	E3	NNP
cord-254492-42d77vxf	20	28	)	)	-RRB-
cord-254492-42d77vxf	20	29	.	.	.
cord-254492-42d77vxf	21	1	The	the	DT
cord-254492-42d77vxf	21	2	E3	E3	NNP
cord-254492-42d77vxf	21	3	largely	largely	RB
cord-254492-42d77vxf	21	4	dictates	dictate	VBZ
cord-254492-42d77vxf	21	5	substrate	substrate	NN
cord-254492-42d77vxf	21	6	specificity	specificity	NN
cord-254492-42d77vxf	21	7	,	,	,
cord-254492-42d77vxf	21	8	with	with	IN
cord-254492-42d77vxf	21	9	at	at	RB
cord-254492-42d77vxf	21	10	least	least	RBS
cord-254492-42d77vxf	21	11	617	617	CD
cord-254492-42d77vxf	21	12	genes	gene	NNS
cord-254492-42d77vxf	21	13	encoding	encode	VBG
cord-254492-42d77vxf	21	14	putative	putative	JJ
cord-254492-42d77vxf	21	15	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	21	16	and	and	CC
cord-254492-42d77vxf	21	17	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	21	18	-	-	HYPH
cord-254492-42d77vxf	21	19	like	like	JJ
cord-254492-42d77vxf	21	20	E3s	e3s	NN
cord-254492-42d77vxf	21	21	annotated	annotate	VBN
cord-254492-42d77vxf	21	22	in	in	IN
cord-254492-42d77vxf	21	23	the	the	DT
cord-254492-42d77vxf	21	24	human	human	JJ
cord-254492-42d77vxf	21	25	genome	genome	NN
cord-254492-42d77vxf	22	1	(	(	-LRB-
cord-254492-42d77vxf	22	2	Li	Li	NNP
cord-254492-42d77vxf	22	3	et	et	NNP
cord-254492-42d77vxf	22	4	al	al	NNP
cord-254492-42d77vxf	22	5	.	.	NNP
cord-254492-42d77vxf	22	6	,	,	,
cord-254492-42d77vxf	22	7	2008	2008	CD
cord-254492-42d77vxf	22	8	)	)	-RRB-
cord-254492-42d77vxf	22	9	.	.	.
cord-254492-42d77vxf	23	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	23	2	can	can	MD
cord-254492-42d77vxf	23	3	undergo	undergo	VB
cord-254492-42d77vxf	23	4	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	23	5	itself	-PRON-	PRP
cord-254492-42d77vxf	23	6	at	at	IN
cord-254492-42d77vxf	23	7	its	-PRON-	PRP$
cord-254492-42d77vxf	23	8	seven	seven	CD
cord-254492-42d77vxf	23	9	lysine	lysine	NN
cord-254492-42d77vxf	23	10	residues	residue	NNS
cord-254492-42d77vxf	23	11	(	(	-LRB-
cord-254492-42d77vxf	23	12	K6	K6	NNP
cord-254492-42d77vxf	23	13	/	/	SYM
cord-254492-42d77vxf	23	14	K11	K11	NNP
cord-254492-42d77vxf	23	15	/	/	SYM
cord-254492-42d77vxf	23	16	K27	K27	NNP
cord-254492-42d77vxf	23	17	/	/	SYM
cord-254492-42d77vxf	23	18	K29	K29	NNP
cord-254492-42d77vxf	23	19	/	/	SYM
cord-254492-42d77vxf	23	20	K33	K33	NNP
cord-254492-42d77vxf	23	21	/	/	SYM
cord-254492-42d77vxf	23	22	K48	K48	NNP
cord-254492-42d77vxf	23	23	/	/	SYM
cord-254492-42d77vxf	23	24	K63	K63	NNP
cord-254492-42d77vxf	23	25	)	)	-RRB-
cord-254492-42d77vxf	23	26	,	,	,
cord-254492-42d77vxf	23	27	building	build	VBG
cord-254492-42d77vxf	23	28	lysine	lysine	NN
cord-254492-42d77vxf	23	29	-	-	HYPH
cord-254492-42d77vxf	23	30	linked	link	VBN
cord-254492-42d77vxf	23	31	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	23	32	chains	chain	NNS
cord-254492-42d77vxf	23	33	,	,	,
cord-254492-42d77vxf	23	34	or	or	CC
cord-254492-42d77vxf	23	35	its	-PRON-	PRP$
cord-254492-42d77vxf	23	36	N	n	CD
cord-254492-42d77vxf	23	37	-	-	HYPH
cord-254492-42d77vxf	23	38	terminal	terminal	NN
cord-254492-42d77vxf	23	39	methionine	methionine	NN
cord-254492-42d77vxf	23	40	(	(	-LRB-
cord-254492-42d77vxf	23	41	M1	M1	NNP
cord-254492-42d77vxf	23	42	)	)	-RRB-
cord-254492-42d77vxf	23	43	,	,	,
cord-254492-42d77vxf	23	44	forming	form	VBG
cord-254492-42d77vxf	23	45	linear	linear	JJ
cord-254492-42d77vxf	23	46	polyubiquitin	polyubiquitin	NNS
cord-254492-42d77vxf	23	47	chains	chain	NNS
cord-254492-42d77vxf	23	48	.	.	.
cord-254492-42d77vxf	24	1	Alternatively	alternatively	RB
cord-254492-42d77vxf	24	2	,	,	,
cord-254492-42d77vxf	24	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	24	4	chains	chain	NNS
cord-254492-42d77vxf	24	5	may	may	MD
cord-254492-42d77vxf	24	6	be	be	VB
cord-254492-42d77vxf	24	7	noncovalently	noncovalently	RB
cord-254492-42d77vxf	24	8	associated	associate	VBN
cord-254492-42d77vxf	24	9	with	with	IN
cord-254492-42d77vxf	24	10	target	target	NN
cord-254492-42d77vxf	24	11	proteins	protein	NNS
cord-254492-42d77vxf	24	12	.	.	.
cord-254492-42d77vxf	25	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	25	2	,	,	,
cord-254492-42d77vxf	25	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	25	4	chains	chain	NNS
cord-254492-42d77vxf	25	5	may	may	MD
cord-254492-42d77vxf	25	6	be	be	VB
cord-254492-42d77vxf	25	7	remodeled	remodel	VBN
cord-254492-42d77vxf	25	8	by	by	IN
cord-254492-42d77vxf	25	9	deubiquitinating	deubiquitinate	VBG
cord-254492-42d77vxf	25	10	enzymes	enzyme	NNS
cord-254492-42d77vxf	25	11	(	(	-LRB-
cord-254492-42d77vxf	25	12	DUbs	DUbs	NNP
cord-254492-42d77vxf	25	13	;	;	:
cord-254492-42d77vxf	25	14	Fig	Fig	NNP
cord-254492-42d77vxf	25	15	.	.	NNP
cord-254492-42d77vxf	25	16	1	1	CD
cord-254492-42d77vxf	25	17	)	)	-RRB-
cord-254492-42d77vxf	25	18	.	.	.
cord-254492-42d77vxf	26	1	The	the	DT
cord-254492-42d77vxf	26	2	function	function	NN
cord-254492-42d77vxf	26	3	,	,	,
cord-254492-42d77vxf	26	4	abundance	abundance	NN
cord-254492-42d77vxf	26	5	,	,	,
cord-254492-42d77vxf	26	6	or	or	CC
cord-254492-42d77vxf	26	7	subcellular	subcellular	JJ
cord-254492-42d77vxf	26	8	distribution	distribution	NN
cord-254492-42d77vxf	26	9	of	of	IN
cord-254492-42d77vxf	26	10	proteins	protein	NNS
cord-254492-42d77vxf	26	11	involved	involve	VBN
cord-254492-42d77vxf	26	12	in	in	IN
cord-254492-42d77vxf	26	13	almost	almost	RB
cord-254492-42d77vxf	26	14	every	every	DT
cord-254492-42d77vxf	26	15	cellular	cellular	JJ
cord-254492-42d77vxf	26	16	process	process	NN
cord-254492-42d77vxf	26	17	is	be	VBZ
cord-254492-42d77vxf	26	18	regulated	regulate	VBN
cord-254492-42d77vxf	26	19	in	in	IN
cord-254492-42d77vxf	26	20	this	this	DT
cord-254492-42d77vxf	26	21	way	way	NN
cord-254492-42d77vxf	26	22	,	,	,
cord-254492-42d77vxf	26	23	with	with	IN
cord-254492-42d77vxf	26	24	an	an	DT
cord-254492-42d77vxf	26	25	increasingly	increasingly	RB
cord-254492-42d77vxf	26	26	clear	clear	JJ
cord-254492-42d77vxf	26	27	role	role	NN
cord-254492-42d77vxf	26	28	in	in	IN
cord-254492-42d77vxf	26	29	regulating	regulate	VBG
cord-254492-42d77vxf	26	30	innate	innate	JJ
cord-254492-42d77vxf	26	31	immunity	immunity	NN
cord-254492-42d77vxf	26	32	.	.	.
cord-254492-42d77vxf	27	1	Viruses	virus	NNS
cord-254492-42d77vxf	27	2	are	be	VBP
cord-254492-42d77vxf	27	3	obligate	obligate	VBN
cord-254492-42d77vxf	27	4	intracellular	intracellular	JJ
cord-254492-42d77vxf	27	5	parasites	parasite	NNS
cord-254492-42d77vxf	27	6	that	that	WDT
cord-254492-42d77vxf	27	7	facilitate	facilitate	VBP
cord-254492-42d77vxf	27	8	their	-PRON-	PRP$
cord-254492-42d77vxf	27	9	own	own	JJ
cord-254492-42d77vxf	27	10	replication	replication	NN
cord-254492-42d77vxf	27	11	by	by	IN
cord-254492-42d77vxf	27	12	manipulating	manipulate	VBG
cord-254492-42d77vxf	27	13	the	the	DT
cord-254492-42d77vxf	27	14	host	host	NN
cord-254492-42d77vxf	27	15	cell	cell	NN
cord-254492-42d77vxf	27	16	environment	environment	NN
cord-254492-42d77vxf	27	17	.	.	.
cord-254492-42d77vxf	28	1	Thus	thus	RB
cord-254492-42d77vxf	28	2	,	,	,
cord-254492-42d77vxf	28	3	the	the	DT
cord-254492-42d77vxf	28	4	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	28	5	modification	modification	NN
cord-254492-42d77vxf	28	6	system	system	NN
cord-254492-42d77vxf	28	7	presents	present	VBZ
cord-254492-42d77vxf	28	8	a	a	DT
cord-254492-42d77vxf	28	9	key	key	JJ
cord-254492-42d77vxf	28	10	manipulation	manipulation	NN
cord-254492-42d77vxf	28	11	target	target	NN
cord-254492-42d77vxf	28	12	for	for	IN
cord-254492-42d77vxf	28	13	viruses	virus	NNS
cord-254492-42d77vxf	28	14	to	to	TO
cord-254492-42d77vxf	28	15	circumvent	circumvent	VB
cord-254492-42d77vxf	28	16	antiviral	antiviral	JJ
cord-254492-42d77vxf	28	17	signaling	signal	VBG
cord-254492-42d77vxf	28	18	pathways	pathway	NNS
cord-254492-42d77vxf	28	19	.	.	.
cord-254492-42d77vxf	29	1	Methods	method	NNS
cord-254492-42d77vxf	29	2	for	for	IN
cord-254492-42d77vxf	29	3	this	this	DT
cord-254492-42d77vxf	29	4	include	include	VBP
cord-254492-42d77vxf	29	5	substrate	substrate	NN
cord-254492-42d77vxf	29	6	molecular	molecular	JJ
cord-254492-42d77vxf	29	7	mimicry	mimicry	NN
cord-254492-42d77vxf	29	8	,	,	,
cord-254492-42d77vxf	29	9	binding	binding	NN
cord-254492-42d77vxf	29	10	and	and	CC
cord-254492-42d77vxf	29	11	blocking	block	VBG
cord-254492-42d77vxf	29	12	E3-substrate	e3-substrate	NN
cord-254492-42d77vxf	29	13	pairs	pair	NNS
cord-254492-42d77vxf	29	14	,	,	,
cord-254492-42d77vxf	29	15	expressing	express	VBG
cord-254492-42d77vxf	30	1	virally	virally	RB
cord-254492-42d77vxf	30	2	encoded	encode	VBN
cord-254492-42d77vxf	30	3	E3s	e3s	NN
cord-254492-42d77vxf	30	4	/	/	SYM
cord-254492-42d77vxf	30	5	DUbs	DUbs	NNP
cord-254492-42d77vxf	30	6	,	,	,
cord-254492-42d77vxf	30	7	and	and	CC
cord-254492-42d77vxf	30	8	hijacking	hijacking	NN
cord-254492-42d77vxf	30	9	host	host	NN
cord-254492-42d77vxf	31	1	E3s	e3s	UH
cord-254492-42d77vxf	32	1	/DUbs	/DUbs	NFP
cord-254492-42d77vxf	32	2	.	.	.
cord-254492-42d77vxf	33	1	Additionally	additionally	RB
cord-254492-42d77vxf	33	2	,	,	,
cord-254492-42d77vxf	33	3	a	a	DT
cord-254492-42d77vxf	33	4	novel	novel	JJ
cord-254492-42d77vxf	33	5	mechanism	mechanism	NN
cord-254492-42d77vxf	33	6	involving	involve	VBG
cord-254492-42d77vxf	33	7	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	33	8	chain	chain	NN
cord-254492-42d77vxf	33	9	packaging	packaging	NN
cord-254492-42d77vxf	33	10	into	into	IN
cord-254492-42d77vxf	33	11	nascent	nascent	JJ
cord-254492-42d77vxf	33	12	virions	virion	NNS
cord-254492-42d77vxf	33	13	for	for	IN
cord-254492-42d77vxf	33	14	subsequent	subsequent	JJ
cord-254492-42d77vxf	33	15	redeployment	redeployment	NN
cord-254492-42d77vxf	33	16	Viral	viral	JJ
cord-254492-42d77vxf	33	17	infection	infection	NN
cord-254492-42d77vxf	33	18	activates	activate	VBZ
cord-254492-42d77vxf	33	19	danger	danger	NN
cord-254492-42d77vxf	33	20	signals	signal	NNS
cord-254492-42d77vxf	33	21	that	that	WDT
cord-254492-42d77vxf	33	22	are	be	VBP
cord-254492-42d77vxf	33	23	transmitted	transmit	VBN
cord-254492-42d77vxf	33	24	via	via	IN
cord-254492-42d77vxf	33	25	the	the	DT
cord-254492-42d77vxf	33	26	retinoic	retinoic	JJ
cord-254492-42d77vxf	33	27	acid	acid	NN
cord-254492-42d77vxf	33	28	-	-	HYPH
cord-254492-42d77vxf	33	29	inducible	inducible	JJ
cord-254492-42d77vxf	33	30	gene	gene	NN
cord-254492-42d77vxf	33	31	1-like	1-like	CD
cord-254492-42d77vxf	33	32	receptor	receptor	NN
cord-254492-42d77vxf	33	33	(	(	-LRB-
cord-254492-42d77vxf	33	34	RLR	RLR	NNP
cord-254492-42d77vxf	33	35	)	)	-RRB-
cord-254492-42d77vxf	33	36	,	,	,
cord-254492-42d77vxf	33	37	nucleotide	nucleotide	NN
cord-254492-42d77vxf	33	38	-	-	HYPH
cord-254492-42d77vxf	33	39	binding	bind	VBG
cord-254492-42d77vxf	33	40	oligomerization	oligomerization	NN
cord-254492-42d77vxf	33	41	domain	domain	NN
cord-254492-42d77vxf	33	42	-	-	HYPH
cord-254492-42d77vxf	33	43	like	like	JJ
cord-254492-42d77vxf	33	44	receptor	receptor	NN
cord-254492-42d77vxf	33	45	(	(	-LRB-
cord-254492-42d77vxf	33	46	NLR	NLR	NNP
cord-254492-42d77vxf	33	47	)	)	-RRB-
cord-254492-42d77vxf	33	48	,	,	,
cord-254492-42d77vxf	33	49	and	and	CC
cord-254492-42d77vxf	33	50	Toll	toll	NN
cord-254492-42d77vxf	33	51	-	-	HYPH
cord-254492-42d77vxf	33	52	like	like	JJ
cord-254492-42d77vxf	33	53	receptor	receptor	NN
cord-254492-42d77vxf	33	54	(	(	-LRB-
cord-254492-42d77vxf	33	55	TLR	TLR	NNP
cord-254492-42d77vxf	33	56	)	)	-RRB-
cord-254492-42d77vxf	33	57	protein	protein	NN
cord-254492-42d77vxf	33	58	signaling	signal	VBG
cord-254492-42d77vxf	33	59	cascades	cascade	NNS
cord-254492-42d77vxf	33	60	.	.	.
cord-254492-42d77vxf	34	1	This	this	DT
cord-254492-42d77vxf	34	2	places	place	NNS
cord-254492-42d77vxf	34	3	host	host	NN
cord-254492-42d77vxf	34	4	cells	cell	NNS
cord-254492-42d77vxf	34	5	in	in	IN
cord-254492-42d77vxf	34	6	an	an	DT
cord-254492-42d77vxf	34	7	antiviral	antiviral	JJ
cord-254492-42d77vxf	34	8	posture	posture	NN
cord-254492-42d77vxf	34	9	by	by	IN
cord-254492-42d77vxf	34	10	up	up	IN
cord-254492-42d77vxf	34	11	-	-	HYPH
cord-254492-42d77vxf	34	12	regulating	regulate	VBG
cord-254492-42d77vxf	34	13	antiviral	antiviral	JJ
cord-254492-42d77vxf	34	14	cytokines	cytokine	NNS
cord-254492-42d77vxf	34	15	including	include	VBG
cord-254492-42d77vxf	34	16	type	type	NN
cord-254492-42d77vxf	34	17	-	-	:
cord-254492-42d77vxf	34	18	I	-PRON-	PRP
cord-254492-42d77vxf	34	19	interferon	interferon	NN
cord-254492-42d77vxf	34	20	(	(	-LRB-
cord-254492-42d77vxf	34	21	IFN	IFN	NNP
cord-254492-42d77vxf	34	22	-	-	HYPH
cord-254492-42d77vxf	34	23	I	I	NNP
cord-254492-42d77vxf	34	24	)	)	-RRB-
cord-254492-42d77vxf	34	25	.	.	.
cord-254492-42d77vxf	35	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	35	2	modifications	modification	NNS
cord-254492-42d77vxf	35	3	and	and	CC
cord-254492-42d77vxf	35	4	cross	cross	NN
cord-254492-42d77vxf	35	5	-	-	NN
cord-254492-42d77vxf	35	6	talk	talk	NN
cord-254492-42d77vxf	35	7	between	between	IN
cord-254492-42d77vxf	35	8	proteins	protein	NNS
cord-254492-42d77vxf	35	9	within	within	IN
cord-254492-42d77vxf	35	10	these	these	DT
cord-254492-42d77vxf	35	11	signaling	signal	VBG
cord-254492-42d77vxf	35	12	cascades	cascade	NNS
cord-254492-42d77vxf	35	13	potentiate	potentiate	VBP
cord-254492-42d77vxf	35	14	IFN	IFN	NNP
cord-254492-42d77vxf	35	15	-	-	HYPH
cord-254492-42d77vxf	35	16	I	-PRON-	PRP
cord-254492-42d77vxf	35	17	expression	expression	NN
cord-254492-42d77vxf	35	18	,	,	,
cord-254492-42d77vxf	35	19	and	and	CC
cord-254492-42d77vxf	35	20	inversely	inversely	RB
cord-254492-42d77vxf	35	21	,	,	,
cord-254492-42d77vxf	35	22	a	a	DT
cord-254492-42d77vxf	35	23	growing	grow	VBG
cord-254492-42d77vxf	35	24	number	number	NN
cord-254492-42d77vxf	35	25	of	of	IN
cord-254492-42d77vxf	35	26	viruses	virus	NNS
cord-254492-42d77vxf	35	27	are	be	VBP
cord-254492-42d77vxf	35	28	found	find	VBN
cord-254492-42d77vxf	35	29	to	to	TO
cord-254492-42d77vxf	35	30	weaponize	weaponize	VB
cord-254492-42d77vxf	35	31	the	the	DT
cord-254492-42d77vxf	35	32	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	35	33	modification	modification	NN
cord-254492-42d77vxf	35	34	system	system	NN
cord-254492-42d77vxf	35	35	to	to	TO
cord-254492-42d77vxf	35	36	suppress	suppress	VB
cord-254492-42d77vxf	35	37	IFN	IFN	NNP
cord-254492-42d77vxf	35	38	-	-	HYPH
cord-254492-42d77vxf	35	39	I.	I.	NNP
cord-254492-42d77vxf	36	1	Here	here	RB
cord-254492-42d77vxf	36	2	we	-PRON-	PRP
cord-254492-42d77vxf	36	3	review	review	VBP
cord-254492-42d77vxf	36	4	how	how	WRB
cord-254492-42d77vxf	36	5	host	host	NN
cord-254492-42d77vxf	36	6	-	-	:
cord-254492-42d77vxf	36	7	and	and	CC
cord-254492-42d77vxf	36	8	virus	virus	NN
cord-254492-42d77vxf	36	9	-	-	HYPH
cord-254492-42d77vxf	36	10	directed	direct	VBN
cord-254492-42d77vxf	36	11	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	36	12	modification	modification	NN
cord-254492-42d77vxf	36	13	of	of	IN
cord-254492-42d77vxf	36	14	proteins	protein	NNS
cord-254492-42d77vxf	36	15	in	in	IN
cord-254492-42d77vxf	36	16	the	the	DT
cord-254492-42d77vxf	36	17	RLR	RLR	NNP
cord-254492-42d77vxf	36	18	,	,	,
cord-254492-42d77vxf	36	19	NLR	NLR	NNP
cord-254492-42d77vxf	36	20	,	,	,
cord-254492-42d77vxf	36	21	and	and	CC
cord-254492-42d77vxf	36	22	TLR	TLR	NNP
cord-254492-42d77vxf	36	23	antiviral	antiviral	JJ
cord-254492-42d77vxf	36	24	signaling	signaling	NN
cord-254492-42d77vxf	36	25	cascades	cascade	NNS
cord-254492-42d77vxf	36	26	modulate	modulate	VBP
cord-254492-42d77vxf	36	27	IFN	IFN	NNP
cord-254492-42d77vxf	36	28	-	-	HYPH
cord-254492-42d77vxf	36	29	I	-PRON-	PRP
cord-254492-42d77vxf	36	30	expression	expression	NN
cord-254492-42d77vxf	36	31	.	.	.
cord-254492-42d77vxf	37	1	localization	localization	NN
cord-254492-42d77vxf	37	2	changes	change	NNS
cord-254492-42d77vxf	37	3	from	from	IN
cord-254492-42d77vxf	37	4	the	the	DT
cord-254492-42d77vxf	37	5	cytosol	cytosol	NN
cord-254492-42d77vxf	37	6	to	to	IN
cord-254492-42d77vxf	37	7	distinct	distinct	JJ
cord-254492-42d77vxf	37	8	subcellular	subcellular	JJ
cord-254492-42d77vxf	37	9	compartments	compartment	NNS
cord-254492-42d77vxf	37	10	depending	depend	VBG
cord-254492-42d77vxf	37	11	on	on	IN
cord-254492-42d77vxf	37	12	upstream	upstream	JJ
cord-254492-42d77vxf	37	13	signaling	signal	VBG
cord-254492-42d77vxf	37	14	events	event	NNS
cord-254492-42d77vxf	37	15	(	(	-LRB-
cord-254492-42d77vxf	37	16	Goncalves	Goncalves	NNP
cord-254492-42d77vxf	37	17	et	et	FW
cord-254492-42d77vxf	37	18	al	al	NNP
cord-254492-42d77vxf	37	19	.	.	NNP
cord-254492-42d77vxf	37	20	,	,	,
cord-254492-42d77vxf	37	21	2011	2011	CD
cord-254492-42d77vxf	37	22	)	)	-RRB-
cord-254492-42d77vxf	37	23	.	.	.
cord-254492-42d77vxf	38	1	In	in	IN
cord-254492-42d77vxf	38	2	promoting	promote	VBG
cord-254492-42d77vxf	38	3	IFN	IFN	NNP
cord-254492-42d77vxf	38	4	-	-	HYPH
cord-254492-42d77vxf	38	5	I	I	NNP
cord-254492-42d77vxf	38	6	signaling	signal	VBG
cord-254492-42d77vxf	38	7	,	,	,
cord-254492-42d77vxf	38	8	TBK1	TBK1	NNP
cord-254492-42d77vxf	38	9	associates	associate	NNS
cord-254492-42d77vxf	38	10	with	with	IN
cord-254492-42d77vxf	38	11	RIG	rig	NN
cord-254492-42d77vxf	38	12	-	-	:
cord-254492-42d77vxf	38	13	I	-PRON-	PRP
cord-254492-42d77vxf	38	14	as	as	RB
cord-254492-42d77vxf	38	15	well	well	RB
cord-254492-42d77vxf	38	16	as	as	IN
cord-254492-42d77vxf	38	17	key	key	JJ
cord-254492-42d77vxf	38	18	adaptor	adaptor	NN
cord-254492-42d77vxf	38	19	proteins	protein	NNS
cord-254492-42d77vxf	38	20	,	,	,
cord-254492-42d77vxf	38	21	including	include	VBG
cord-254492-42d77vxf	38	22	TANK	tank	NN
cord-254492-42d77vxf	38	23	and	and	CC
cord-254492-42d77vxf	38	24	NF	nf	NN
cord-254492-42d77vxf	38	25	-	-	HYPH
cord-254492-42d77vxf	38	26	κB	κb	CD
cord-254492-42d77vxf	38	27	essential	essential	JJ
cord-254492-42d77vxf	38	28	modulator	modulator	NN
cord-254492-42d77vxf	38	29	(	(	-LRB-
cord-254492-42d77vxf	38	30	NEMO	NEMO	NNP
cord-254492-42d77vxf	38	31	;	;	:
cord-254492-42d77vxf	38	32	Guo	Guo	NNP
cord-254492-42d77vxf	38	33	and	and	CC
cord-254492-42d77vxf	38	34	Cheng	Cheng	NNP
cord-254492-42d77vxf	38	35	,	,	,
cord-254492-42d77vxf	38	36	2007	2007	CD
cord-254492-42d77vxf	38	37	;	;	:
cord-254492-42d77vxf	38	38	Zhao	Zhao	NNP
cord-254492-42d77vxf	38	39	et	et	NNP
cord-254492-42d77vxf	38	40	al	al	NNP
cord-254492-42d77vxf	38	41	.	.	NNP
cord-254492-42d77vxf	38	42	,	,	,
cord-254492-42d77vxf	38	43	2007	2007	CD
cord-254492-42d77vxf	38	44	;	;	:
cord-254492-42d77vxf	38	45	Wang	Wang	NNP
cord-254492-42d77vxf	38	46	et	et	NNP
cord-254492-42d77vxf	38	47	al	al	NNP
cord-254492-42d77vxf	38	48	.	.	NNP
cord-254492-42d77vxf	38	49	,	,	,
cord-254492-42d77vxf	38	50	2012a	2012a	CD
cord-254492-42d77vxf	38	51	)	)	-RRB-
cord-254492-42d77vxf	38	52	.	.	.
cord-254492-42d77vxf	39	1	This	this	DT
cord-254492-42d77vxf	39	2	facilitates	facilitate	VBZ
cord-254492-42d77vxf	39	3	interactions	interaction	NNS
cord-254492-42d77vxf	39	4	between	between	IN
cord-254492-42d77vxf	39	5	TBK1	TBK1	NNP
cord-254492-42d77vxf	39	6	,	,	,
cord-254492-42d77vxf	39	7	inhibitor	inhibitor	NN
cord-254492-42d77vxf	39	8	of	of	IN
cord-254492-42d77vxf	39	9	NF	nf	NN
cord-254492-42d77vxf	39	10	-	-	HYPH
cord-254492-42d77vxf	39	11	κB	κB	NNP
cord-254492-42d77vxf	39	12	kinase	kinase	NN
cord-254492-42d77vxf	39	13	subunit	subunit	NN
cord-254492-42d77vxf	39	14	ε	ε	NN
cord-254492-42d77vxf	39	15	(	(	-LRB-
cord-254492-42d77vxf	39	16	IKKε	IKKε	NNP
cord-254492-42d77vxf	39	17	)	)	-RRB-
cord-254492-42d77vxf	39	18	and	and	CC
cord-254492-42d77vxf	39	19	TRAFs	traf	NNS
cord-254492-42d77vxf	39	20	,	,	,
cord-254492-42d77vxf	39	21	particularly	particularly	RB
cord-254492-42d77vxf	39	22	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	39	23	.	.	.
cord-254492-42d77vxf	40	1	Upon	upon	IN
cord-254492-42d77vxf	40	2	RLR	RLR	NNP
cord-254492-42d77vxf	40	3	activation	activation	NN
cord-254492-42d77vxf	40	4	,	,	,
cord-254492-42d77vxf	40	5	these	these	DT
cord-254492-42d77vxf	40	6	proteins	protein	NNS
cord-254492-42d77vxf	40	7	are	be	VBP
cord-254492-42d77vxf	40	8	colocalized	colocalize	VBN
cord-254492-42d77vxf	40	9	at	at	IN
cord-254492-42d77vxf	40	10	the	the	DT
cord-254492-42d77vxf	40	11	cytosolic	cytosolic	JJ
cord-254492-42d77vxf	40	12	surface	surface	NN
cord-254492-42d77vxf	40	13	of	of	IN
cord-254492-42d77vxf	40	14	the	the	DT
cord-254492-42d77vxf	40	15	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	40	16	outer	outer	JJ
cord-254492-42d77vxf	40	17	membrane	membrane	NN
cord-254492-42d77vxf	41	1	(	(	-LRB-
cord-254492-42d77vxf	41	2	Parvatiyar	Parvatiyar	NNP
cord-254492-42d77vxf	41	3	et	et	NNP
cord-254492-42d77vxf	41	4	al	al	NNP
cord-254492-42d77vxf	41	5	.	.	NNP
cord-254492-42d77vxf	41	6	,	,	,
cord-254492-42d77vxf	41	7	2010	2010	CD
cord-254492-42d77vxf	41	8	;	;	:
cord-254492-42d77vxf	41	9	van	van	NNP
cord-254492-42d77vxf	41	10	Zuylen	Zuylen	NNP
cord-254492-42d77vxf	41	11	et	et	NNP
cord-254492-42d77vxf	41	12	al	al	NNP
cord-254492-42d77vxf	41	13	.	.	NNP
cord-254492-42d77vxf	41	14	,	,	,
cord-254492-42d77vxf	41	15	2012	2012	CD
cord-254492-42d77vxf	41	16	)	)	-RRB-
cord-254492-42d77vxf	41	17	,	,	,
cord-254492-42d77vxf	41	18	coordinated	coordinate	VBN
cord-254492-42d77vxf	41	19	by	by	IN
cord-254492-42d77vxf	41	20	the	the	DT
cord-254492-42d77vxf	41	21	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	41	22	antiviral	antiviral	JJ
cord-254492-42d77vxf	41	23	-	-	HYPH
cord-254492-42d77vxf	41	24	signaling	signal	VBG
cord-254492-42d77vxf	41	25	protein	protein	NN
cord-254492-42d77vxf	41	26	(	(	-LRB-
cord-254492-42d77vxf	41	27	MAVS	mavs	RB
cord-254492-42d77vxf	41	28	;	;	:
cord-254492-42d77vxf	41	29	also	also	RB
cord-254492-42d77vxf	41	30	termed	term	VBN
cord-254492-42d77vxf	41	31	VISA	VISA	NNP
cord-254492-42d77vxf	41	32	/	/	SYM
cord-254492-42d77vxf	41	33	Cardif	Cardif	NNP
cord-254492-42d77vxf	41	34	/	/	SYM
cord-254492-42d77vxf	41	35	IPS-1	IPS-1	NNP
cord-254492-42d77vxf	41	36	)	)	-RRB-
cord-254492-42d77vxf	41	37	.	.	.
cord-254492-42d77vxf	42	1	At	at	IN
cord-254492-42d77vxf	42	2	rest	rest	NN
cord-254492-42d77vxf	42	3	,	,	,
cord-254492-42d77vxf	42	4	the	the	DT
cord-254492-42d77vxf	42	5	RLR	RLR	NNP
cord-254492-42d77vxf	42	6	cascade	cascade	NN
cord-254492-42d77vxf	42	7	is	be	VBZ
cord-254492-42d77vxf	42	8	maintained	maintain	VBN
cord-254492-42d77vxf	42	9	in	in	IN
cord-254492-42d77vxf	42	10	an	an	DT
cord-254492-42d77vxf	42	11	inactive	inactive	JJ
cord-254492-42d77vxf	42	12	but	but	CC
cord-254492-42d77vxf	42	13	tensioned	tensione	VBN
cord-254492-42d77vxf	42	14	state	state	NN
cord-254492-42d77vxf	42	15	through	through	IN
cord-254492-42d77vxf	42	16	an	an	DT
cord-254492-42d77vxf	42	17	intricate	intricate	JJ
cord-254492-42d77vxf	42	18	negative	negative	JJ
cord-254492-42d77vxf	42	19	feedback	feedback	NN
cord-254492-42d77vxf	42	20	system	system	NN
cord-254492-42d77vxf	42	21	involving	involve	VBG
cord-254492-42d77vxf	42	22	protein	protein	NN
cord-254492-42d77vxf	42	23	expression	expression	NN
cord-254492-42d77vxf	42	24	levels	level	NNS
cord-254492-42d77vxf	42	25	,	,	,
cord-254492-42d77vxf	42	26	conformational	conformational	JJ
cord-254492-42d77vxf	42	27	changes	change	NNS
cord-254492-42d77vxf	42	28	,	,	,
cord-254492-42d77vxf	42	29	compartmentalization	compartmentalization	NN
cord-254492-42d77vxf	42	30	,	,	,
cord-254492-42d77vxf	42	31	and	and	CC
cord-254492-42d77vxf	42	32	PTMs	ptm	NNS
cord-254492-42d77vxf	42	33	.	.	.
cord-254492-42d77vxf	43	1	Part	part	NN
cord-254492-42d77vxf	43	2	of	of	IN
cord-254492-42d77vxf	43	3	this	this	DT
cord-254492-42d77vxf	43	4	system	system	NN
cord-254492-42d77vxf	43	5	operates	operate	VBZ
cord-254492-42d77vxf	43	6	at	at	IN
cord-254492-42d77vxf	43	7	the	the	DT
cord-254492-42d77vxf	43	8	receptor	receptor	NN
cord-254492-42d77vxf	43	9	through	through	IN
cord-254492-42d77vxf	43	10	conformational	conformational	JJ
cord-254492-42d77vxf	43	11	auto	auto	NN
cord-254492-42d77vxf	43	12	-	-	HYPH
cord-254492-42d77vxf	43	13	inhibition	inhibition	NN
cord-254492-42d77vxf	43	14	of	of	IN
cord-254492-42d77vxf	43	15	the	the	DT
cord-254492-42d77vxf	43	16	RIG	rig	NN
cord-254492-42d77vxf	43	17	-	-	HYPH
cord-254492-42d77vxf	43	18	I	i	NN
cord-254492-42d77vxf	43	19	CARDs	card	NNS
cord-254492-42d77vxf	43	20	.	.	.
cord-254492-42d77vxf	44	1	The	the	DT
cord-254492-42d77vxf	44	2	RIG	rig	NN
cord-254492-42d77vxf	44	3	-	-	:
cord-254492-42d77vxf	44	4	I	I	NNP
cord-254492-42d77vxf	44	5	C	c	NN
cord-254492-42d77vxf	44	6	-	-	HYPH
cord-254492-42d77vxf	44	7	terminal	terminal	NN
cord-254492-42d77vxf	44	8	repressor	repressor	NN
cord-254492-42d77vxf	44	9	domain	domain	NN
cord-254492-42d77vxf	44	10	(	(	-LRB-
cord-254492-42d77vxf	44	11	RD	RD	NNP
cord-254492-42d77vxf	44	12	)	)	-RRB-
cord-254492-42d77vxf	44	13	audits	audits	VBP
cord-254492-42d77vxf	44	14	the	the	DT
cord-254492-42d77vxf	44	15	cytosol	cytosol	NN
cord-254492-42d77vxf	44	16	for	for	IN
cord-254492-42d77vxf	44	17	viral	viral	JJ
cord-254492-42d77vxf	44	18	RNA	RNA	NNP
cord-254492-42d77vxf	44	19	,	,	,
cord-254492-42d77vxf	44	20	binding	binding	NN
cord-254492-42d77vxf	44	21	of	of	IN
cord-254492-42d77vxf	44	22	which	which	WDT
cord-254492-42d77vxf	44	23	induces	induce	VBZ
cord-254492-42d77vxf	44	24	a	a	DT
cord-254492-42d77vxf	44	25	major	major	JJ
cord-254492-42d77vxf	44	26	structural	structural	JJ
cord-254492-42d77vxf	44	27	rearrangement	rearrangement	NN
cord-254492-42d77vxf	44	28	in	in	IN
cord-254492-42d77vxf	44	29	the	the	DT
cord-254492-42d77vxf	44	30	RD	RD	NNP
cord-254492-42d77vxf	44	31	and	and	CC
cord-254492-42d77vxf	44	32	CARD	CARD	NNP
cord-254492-42d77vxf	45	1	(	(	-LRB-
cord-254492-42d77vxf	45	2	Saito	Saito	NNP
cord-254492-42d77vxf	45	3	et	et	NNP
cord-254492-42d77vxf	45	4	al	al	NNP
cord-254492-42d77vxf	45	5	.	.	NNP
cord-254492-42d77vxf	45	6	,	,	,
cord-254492-42d77vxf	45	7	2007	2007	CD
cord-254492-42d77vxf	45	8	)	)	-RRB-
cord-254492-42d77vxf	45	9	.	.	.
cord-254492-42d77vxf	46	1	Conversely	conversely	RB
cord-254492-42d77vxf	46	2	,	,	,
cord-254492-42d77vxf	46	3	MDA5	MDA5	NNP
cord-254492-42d77vxf	46	4	oligomerizes	oligomerize	NNS
cord-254492-42d77vxf	46	5	along	along	IN
cord-254492-42d77vxf	46	6	the	the	DT
cord-254492-42d77vxf	46	7	length	length	NN
cord-254492-42d77vxf	46	8	of	of	IN
cord-254492-42d77vxf	46	9	RNA	rna	NN
cord-254492-42d77vxf	46	10	ligands	ligand	NNS
cord-254492-42d77vxf	46	11	,	,	,
cord-254492-42d77vxf	46	12	forming	form	VBG
cord-254492-42d77vxf	46	13	immunogenic	immunogenic	JJ
cord-254492-42d77vxf	46	14	filaments	filament	NNS
cord-254492-42d77vxf	46	15	that	that	WDT
cord-254492-42d77vxf	46	16	are	be	VBP
cord-254492-42d77vxf	46	17	potentiated	potentiate	VBN
cord-254492-42d77vxf	46	18	by	by	IN
cord-254492-42d77vxf	46	19	ATP	ATP	NNP
cord-254492-42d77vxf	46	20	hydrolysis	hydrolysis	NN
cord-254492-42d77vxf	46	21	and	and	CC
cord-254492-42d77vxf	46	22	interaction	interaction	NN
cord-254492-42d77vxf	46	23	with	with	IN
cord-254492-42d77vxf	46	24	LGP2	LGP2	NNP
cord-254492-42d77vxf	46	25	(	(	-LRB-
cord-254492-42d77vxf	46	26	Peisley	Peisley	NNP
cord-254492-42d77vxf	46	27	et	et	NNP
cord-254492-42d77vxf	46	28	al	al	NNP
cord-254492-42d77vxf	46	29	.	.	NNP
cord-254492-42d77vxf	46	30	,	,	,
cord-254492-42d77vxf	46	31	2012	2012	CD
cord-254492-42d77vxf	46	32	;	;	:
cord-254492-42d77vxf	46	33	Bruns	Bruns	NNP
cord-254492-42d77vxf	46	34	et	et	NNP
cord-254492-42d77vxf	46	35	al	al	NNP
cord-254492-42d77vxf	46	36	.	.	.
cord-254492-42d77vxf	47	1	,	,	,
cord-254492-42d77vxf	47	2	2014	2014	CD
cord-254492-42d77vxf	47	3	)	)	-RRB-
cord-254492-42d77vxf	47	4	.	.	.
cord-254492-42d77vxf	48	1	The	the	DT
cord-254492-42d77vxf	48	2	unfurled	unfurl	VBN
cord-254492-42d77vxf	48	3	RIG	rig	NN
cord-254492-42d77vxf	48	4	-	-	:
cord-254492-42d77vxf	48	5	I	-PRON-	PRP
cord-254492-42d77vxf	48	6	CARDs	card	NNS
cord-254492-42d77vxf	48	7	undergo	undergo	VB
cord-254492-42d77vxf	48	8	tetramerization	tetramerization	NN
cord-254492-42d77vxf	48	9	upon	upon	IN
cord-254492-42d77vxf	48	10	K63-linked	k63-linked	JJ
cord-254492-42d77vxf	48	11	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	48	12	or	or	CC
cord-254492-42d77vxf	48	13	unanchored	unanchored	JJ
cord-254492-42d77vxf	48	14	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	48	15	chain	chain	NNP
cord-254492-42d77vxf	48	16	association	association	NNP
cord-254492-42d77vxf	49	1	(	(	-LRB-
cord-254492-42d77vxf	49	2	Peisley	Peisley	NNP
cord-254492-42d77vxf	49	3	et	et	NNP
cord-254492-42d77vxf	49	4	al	al	NNP
cord-254492-42d77vxf	49	5	.	.	NNP
cord-254492-42d77vxf	49	6	,	,	,
cord-254492-42d77vxf	49	7	2014	2014	CD
cord-254492-42d77vxf	49	8	)	)	-RRB-
cord-254492-42d77vxf	49	9	.	.	.
cord-254492-42d77vxf	50	1	These	these	DT
cord-254492-42d77vxf	50	2	modifications	modification	NNS
cord-254492-42d77vxf	50	3	drive	drive	VBP
cord-254492-42d77vxf	50	4	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	50	5	accumulation	accumulation	NN
cord-254492-42d77vxf	50	6	of	of	IN
cord-254492-42d77vxf	50	7	RIG	rig	NN
cord-254492-42d77vxf	50	8	-	-	:
cord-254492-42d77vxf	50	9	I	i	NN
cord-254492-42d77vxf	50	10	,	,	,
cord-254492-42d77vxf	50	11	promoting	promote	VBG
cord-254492-42d77vxf	50	12	CARD	card	NN
cord-254492-42d77vxf	50	13	-	-	HYPH
cord-254492-42d77vxf	50	14	CARD	card	NN
cord-254492-42d77vxf	50	15	interac-	interac-	NN
cord-254492-42d77vxf	50	16	(	(	-LRB-
cord-254492-42d77vxf	50	17	1	1	LS
cord-254492-42d77vxf	50	18	)	)	-RRB-
cord-254492-42d77vxf	50	19	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	50	20	(	(	-LRB-
cord-254492-42d77vxf	50	21	Ub	Ub	NNP
cord-254492-42d77vxf	50	22	)	)	-RRB-
cord-254492-42d77vxf	50	23	expresses	express	VBZ
cord-254492-42d77vxf	50	24	as	as	IN
cord-254492-42d77vxf	50	25	an	an	DT
cord-254492-42d77vxf	50	26	inactive	inactive	JJ
cord-254492-42d77vxf	50	27	polyprotein	polyprotein	NN
cord-254492-42d77vxf	50	28	,	,	,
cord-254492-42d77vxf	50	29	encoded	encode	VBN
cord-254492-42d77vxf	50	30	by	by	IN
cord-254492-42d77vxf	50	31	the	the	DT
cord-254492-42d77vxf	50	32	UBB	UBB	NNP
cord-254492-42d77vxf	50	33	and	and	CC
cord-254492-42d77vxf	50	34	UBC	UBC	NNP
cord-254492-42d77vxf	50	35	genes	gene	NNS
cord-254492-42d77vxf	50	36	.	.	.
cord-254492-42d77vxf	51	1	DUbs	DUbs	NNP
cord-254492-42d77vxf	51	2	cleave	cleave	VBP
cord-254492-42d77vxf	51	3	this	this	DT
cord-254492-42d77vxf	51	4	polyprotein	polyprotein	NN
cord-254492-42d77vxf	51	5	into	into	IN
cord-254492-42d77vxf	51	6	monomers	monomer	NNS
cord-254492-42d77vxf	51	7	that	that	WDT
cord-254492-42d77vxf	51	8	are	be	VBP
cord-254492-42d77vxf	51	9	activated	activate	VBN
cord-254492-42d77vxf	51	10	by	by	IN
cord-254492-42d77vxf	51	11	the	the	DT
cord-254492-42d77vxf	51	12	E1-activating	e1-activating	NN
cord-254492-42d77vxf	51	13	enzyme	enzyme	NN
cord-254492-42d77vxf	51	14	,	,	,
cord-254492-42d77vxf	51	15	involving	involve	VBG
cord-254492-42d77vxf	51	16	the	the	DT
cord-254492-42d77vxf	51	17	energy	energy	NN
cord-254492-42d77vxf	51	18	-	-	HYPH
cord-254492-42d77vxf	51	19	dependent	dependent	JJ
cord-254492-42d77vxf	51	20	adenylation	adenylation	NN
cord-254492-42d77vxf	51	21	of	of	IN
cord-254492-42d77vxf	51	22	the	the	DT
cord-254492-42d77vxf	51	23	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	51	24	C	c	NN
cord-254492-42d77vxf	51	25	-	-	HYPH
cord-254492-42d77vxf	51	26	terminal	terminal	NN
cord-254492-42d77vxf	51	27	glycine	glycine	NN
cord-254492-42d77vxf	51	28	.	.	.
cord-254492-42d77vxf	52	1	The	the	DT
cord-254492-42d77vxf	52	2	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	52	3	-	-	HYPH
cord-254492-42d77vxf	52	4	adenylate	adenylate	NN
cord-254492-42d77vxf	52	5	intermediate	intermediate	NN
cord-254492-42d77vxf	52	6	(	(	-LRB-
cord-254492-42d77vxf	52	7	dashed	dash	VBN
cord-254492-42d77vxf	52	8	line	line	NN
cord-254492-42d77vxf	52	9	)	)	-RRB-
cord-254492-42d77vxf	52	10	converts	convert	VBZ
cord-254492-42d77vxf	52	11	into	into	IN
cord-254492-42d77vxf	52	12	a	a	DT
cord-254492-42d77vxf	52	13	covalent	covalent	JJ
cord-254492-42d77vxf	52	14	thioester	thioester	NN
cord-254492-42d77vxf	52	15	bond	bond	NN
cord-254492-42d77vxf	52	16	(	(	-LRB-
cord-254492-42d77vxf	52	17	solid	solid	JJ
cord-254492-42d77vxf	52	18	line	line	NN
cord-254492-42d77vxf	52	19	)	)	-RRB-
cord-254492-42d77vxf	52	20	.	.	.
cord-254492-42d77vxf	53	1	(	(	-LRB-
cord-254492-42d77vxf	53	2	2	2	LS
cord-254492-42d77vxf	53	3	)	)	-RRB-
cord-254492-42d77vxf	53	4	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	53	5	transfers	transfer	NNS
cord-254492-42d77vxf	53	6	to	to	IN
cord-254492-42d77vxf	53	7	the	the	DT
cord-254492-42d77vxf	53	8	active	active	JJ
cord-254492-42d77vxf	53	9	site	site	NN
cord-254492-42d77vxf	53	10	cysteine	cysteine	NN
cord-254492-42d77vxf	53	11	residue	residue	NN
cord-254492-42d77vxf	53	12	of	of	IN
cord-254492-42d77vxf	53	13	an	an	DT
cord-254492-42d77vxf	53	14	E2-conjugating	e2-conjugating	NN
cord-254492-42d77vxf	53	15	enzyme	enzyme	NN
cord-254492-42d77vxf	53	16	.	.	.
cord-254492-42d77vxf	54	1	(	(	-LRB-
cord-254492-42d77vxf	54	2	3	3	LS
cord-254492-42d77vxf	54	3	)	)	-RRB-
cord-254492-42d77vxf	55	1	The	the	DT
cord-254492-42d77vxf	55	2	E3	E3	NNP
cord-254492-42d77vxf	55	3	directly	directly	RB
cord-254492-42d77vxf	55	4	or	or	CC
cord-254492-42d77vxf	55	5	indirectly	indirectly	RB
cord-254492-42d77vxf	55	6	transfers	transfer	VBZ
cord-254492-42d77vxf	55	7	the	the	DT
cord-254492-42d77vxf	55	8	E2-bound	e2-bound	NN
cord-254492-42d77vxf	55	9	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	55	10	to	to	IN
cord-254492-42d77vxf	55	11	a	a	DT
cord-254492-42d77vxf	55	12	substrate	substrate	NN
cord-254492-42d77vxf	55	13	acceptor	acceptor	NN
cord-254492-42d77vxf	55	14	residue	residue	NN
cord-254492-42d77vxf	55	15	,	,	,
cord-254492-42d77vxf	55	16	forming	form	VBG
cord-254492-42d77vxf	55	17	an	an	DT
cord-254492-42d77vxf	55	18	isopeptide	isopeptide	NN
cord-254492-42d77vxf	55	19	bond	bond	NN
cord-254492-42d77vxf	55	20	.	.	.
cord-254492-42d77vxf	56	1	(	(	-LRB-
cord-254492-42d77vxf	56	2	4	4	LS
cord-254492-42d77vxf	56	3	)	)	-RRB-
cord-254492-42d77vxf	57	1	DUbs	DUbs	NNP
cord-254492-42d77vxf	57	2	remodel	remodel	NN
cord-254492-42d77vxf	57	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	57	4	modifications	modification	NNS
cord-254492-42d77vxf	57	5	and	and	CC
cord-254492-42d77vxf	57	6	antagonize	antagonize	VB
cord-254492-42d77vxf	57	7	ubiquitin	ubiquitin	RB
cord-254492-42d77vxf	57	8	-	-	HYPH
cord-254492-42d77vxf	57	9	driven	drive	VBN
cord-254492-42d77vxf	57	10	functional	functional	JJ
cord-254492-42d77vxf	57	11	outcomes	outcome	NNS
cord-254492-42d77vxf	57	12	.	.	.
cord-254492-42d77vxf	58	1	tions	tion	NNS
cord-254492-42d77vxf	58	2	with	with	IN
cord-254492-42d77vxf	58	3	MAVS	MAVS	NNPS
cord-254492-42d77vxf	58	4	and	and	CC
cord-254492-42d77vxf	58	5	inducing	induce	VBG
cord-254492-42d77vxf	58	6	its	-PRON-	PRP$
cord-254492-42d77vxf	58	7	oligomerization	oligomerization	NN
cord-254492-42d77vxf	58	8	and	and	CC
cord-254492-42d77vxf	58	9	filamentation	filamentation	NN
cord-254492-42d77vxf	58	10	.	.	.
cord-254492-42d77vxf	59	1	The	the	DT
cord-254492-42d77vxf	59	2	RIG	rig	NN
cord-254492-42d77vxf	59	3	-	-	:
cord-254492-42d77vxf	59	4	I	-PRON-	PRP
cord-254492-42d77vxf	59	5	CARDs	card	NNS
cord-254492-42d77vxf	59	6	contain	contain	VBP
cord-254492-42d77vxf	59	7	a	a	DT
cord-254492-42d77vxf	59	8	high	high	JJ
cord-254492-42d77vxf	59	9	proportion	proportion	NN
cord-254492-42d77vxf	59	10	of	of	IN
cord-254492-42d77vxf	59	11	hydrophobic	hydrophobic	JJ
cord-254492-42d77vxf	59	12	residues	residue	NNS
cord-254492-42d77vxf	59	13	and	and	CC
cord-254492-42d77vxf	59	14	are	be	VBP
cord-254492-42d77vxf	59	15	prone	prone	JJ
cord-254492-42d77vxf	59	16	to	to	IN
cord-254492-42d77vxf	59	17	aggregation	aggregation	NN
cord-254492-42d77vxf	59	18	,	,	,
cord-254492-42d77vxf	59	19	thus	thus	RB
cord-254492-42d77vxf	59	20	oligomerization	oligomerization	NN
cord-254492-42d77vxf	59	21	and	and	CC
cord-254492-42d77vxf	59	22	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	59	23	may	may	MD
cord-254492-42d77vxf	59	24	stabilize	stabilize	VB
cord-254492-42d77vxf	59	25	the	the	DT
cord-254492-42d77vxf	59	26	activated	activate	VBN
cord-254492-42d77vxf	59	27	CARDs	card	NNS
cord-254492-42d77vxf	59	28	or	or	CC
cord-254492-42d77vxf	59	29	elicit	elicit	VB
cord-254492-42d77vxf	59	30	a	a	DT
cord-254492-42d77vxf	59	31	separate	separate	JJ
cord-254492-42d77vxf	59	32	mitochondrial	mitochondrial	NN
cord-254492-42d77vxf	59	33	targeting	targeting	NN
cord-254492-42d77vxf	59	34	signal	signal	NN
cord-254492-42d77vxf	59	35	.	.	.
cord-254492-42d77vxf	60	1	Conversely	conversely	RB
cord-254492-42d77vxf	60	2	,	,	,
cord-254492-42d77vxf	60	3	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	60	4	has	have	VBZ
cord-254492-42d77vxf	60	5	no	no	DT
cord-254492-42d77vxf	60	6	known	know	VBN
cord-254492-42d77vxf	60	7	role	role	NN
cord-254492-42d77vxf	60	8	in	in	IN
cord-254492-42d77vxf	60	9	MDA5	MDA5	NNP
cord-254492-42d77vxf	60	10	or	or	CC
cord-254492-42d77vxf	60	11	LGP2	LGP2	NNP
cord-254492-42d77vxf	60	12	activation	activation	NN
cord-254492-42d77vxf	60	13	.	.	.
cord-254492-42d77vxf	61	1	The	the	DT
cord-254492-42d77vxf	61	2	first	first	JJ
cord-254492-42d77vxf	61	3	virus	virus	NN
cord-254492-42d77vxf	61	4	-	-	HYPH
cord-254492-42d77vxf	61	5	triggered	trigger	VBN
cord-254492-42d77vxf	61	6	RIG	rig	NN
cord-254492-42d77vxf	61	7	-	-	:
cord-254492-42d77vxf	61	8	I	-PRON-	PRP
cord-254492-42d77vxf	61	9	ubiquitination	ubiquitination	IN
cord-254492-42d77vxf	61	10	site	site	NN
cord-254492-42d77vxf	61	11	described	describe	VBN
cord-254492-42d77vxf	61	12	,	,	,
cord-254492-42d77vxf	61	13	K172	K172	NNP
cord-254492-42d77vxf	61	14	,	,	,
cord-254492-42d77vxf	61	15	depends	depend	VBZ
cord-254492-42d77vxf	61	16	on	on	IN
cord-254492-42d77vxf	61	17	the	the	DT
cord-254492-42d77vxf	61	18	E3	e3	NN
cord-254492-42d77vxf	61	19	activity	activity	NN
cord-254492-42d77vxf	61	20	of	of	IN
cord-254492-42d77vxf	61	21	tripartite	tripartite	JJ
cord-254492-42d77vxf	61	22	motif	motif	NN
cord-254492-42d77vxf	61	23	protein	protein	NN
cord-254492-42d77vxf	61	24	25	25	CD
cord-254492-42d77vxf	62	1	(	(	-LRB-
cord-254492-42d77vxf	62	2	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	62	3	;	;	:
cord-254492-42d77vxf	62	4	Gack	Gack	NNP
cord-254492-42d77vxf	62	5	et	et	FW
cord-254492-42d77vxf	62	6	al	al	NNP
cord-254492-42d77vxf	62	7	.	.	NNP
cord-254492-42d77vxf	62	8	,	,	,
cord-254492-42d77vxf	62	9	2007	2007	CD
cord-254492-42d77vxf	62	10	)	)	-RRB-
cord-254492-42d77vxf	62	11	.	.	.
cord-254492-42d77vxf	63	1	Plausibly	plausibly	RB
cord-254492-42d77vxf	63	2	as	as	IN
cord-254492-42d77vxf	63	3	a	a	DT
cord-254492-42d77vxf	63	4	means	means	NN
cord-254492-42d77vxf	63	5	of	of	IN
cord-254492-42d77vxf	63	6	restricting	restrict	VBG
cord-254492-42d77vxf	63	7	escape	escape	NN
cord-254492-42d77vxf	63	8	mutant	mutant	JJ
cord-254492-42d77vxf	63	9	selection	selection	NN
cord-254492-42d77vxf	63	10	,	,	,
cord-254492-42d77vxf	63	11	this	this	DT
cord-254492-42d77vxf	63	12	activation	activation	NN
cord-254492-42d77vxf	63	13	mechanism	mechanism	NN
cord-254492-42d77vxf	63	14	now	now	RB
cord-254492-42d77vxf	63	15	appears	appear	VBZ
cord-254492-42d77vxf	63	16	to	to	TO
cord-254492-42d77vxf	63	17	have	have	VB
cord-254492-42d77vxf	63	18	evolved	evolve	VBN
cord-254492-42d77vxf	63	19	with	with	IN
cord-254492-42d77vxf	63	20	partial	partial	JJ
cord-254492-42d77vxf	63	21	redundancy	redundancy	NN
cord-254492-42d77vxf	63	22	using	use	VBG
cord-254492-42d77vxf	63	23	alternate	alternate	JJ
cord-254492-42d77vxf	63	24	E3s	e3s	NN
cord-254492-42d77vxf	63	25	.	.	.
cord-254492-42d77vxf	64	1	TRIM4	TRIM4	NNP
cord-254492-42d77vxf	64	2	was	be	VBD
cord-254492-42d77vxf	64	3	recently	recently	RB
cord-254492-42d77vxf	64	4	described	describe	VBN
cord-254492-42d77vxf	64	5	to	to	TO
cord-254492-42d77vxf	64	6	modify	modify	VB
cord-254492-42d77vxf	64	7	this	this	DT
cord-254492-42d77vxf	64	8	same	same	JJ
cord-254492-42d77vxf	64	9	site	site	NN
cord-254492-42d77vxf	64	10	in	in	IN
cord-254492-42d77vxf	64	11	addition	addition	NN
cord-254492-42d77vxf	64	12	to	to	IN
cord-254492-42d77vxf	64	13	two	two	CD
cord-254492-42d77vxf	64	14	other	other	JJ
cord-254492-42d77vxf	64	15	CARD	card	NN
cord-254492-42d77vxf	64	16	residues	residue	NNS
cord-254492-42d77vxf	64	17	:	:	:
cord-254492-42d77vxf	64	18	K154	k154	CD
cord-254492-42d77vxf	64	19	and	and	CC
cord-254492-42d77vxf	64	20	K164	k164	ADD
cord-254492-42d77vxf	65	1	(	(	-LRB-
cord-254492-42d77vxf	65	2	Yan	Yan	NNP
cord-254492-42d77vxf	65	3	et	et	NNP
cord-254492-42d77vxf	65	4	al	al	NNP
cord-254492-42d77vxf	65	5	.	.	NNP
cord-254492-42d77vxf	65	6	,	,	,
cord-254492-42d77vxf	65	7	2014	2014	CD
cord-254492-42d77vxf	65	8	)	)	-RRB-
cord-254492-42d77vxf	65	9	.	.	.
cord-254492-42d77vxf	66	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	66	2	,	,	,
cord-254492-42d77vxf	66	3	these	these	DT
cord-254492-42d77vxf	66	4	same	same	JJ
cord-254492-42d77vxf	66	5	three	three	CD
cord-254492-42d77vxf	66	6	residues	residue	NNS
cord-254492-42d77vxf	66	7	are	be	VBP
cord-254492-42d77vxf	66	8	reportedly	reportedly	RB
cord-254492-42d77vxf	66	9	ubiquitinated	ubiquitinate	VBN
cord-254492-42d77vxf	66	10	by	by	IN
cord-254492-42d77vxf	66	11	really	really	RB
cord-254492-42d77vxf	66	12	interesting	interesting	JJ
cord-254492-42d77vxf	66	13	new	new	JJ
cord-254492-42d77vxf	66	14	gene	gene	NN
cord-254492-42d77vxf	66	15	(	(	-LRB-
cord-254492-42d77vxf	66	16	RING	ring	NN
cord-254492-42d77vxf	66	17	)	)	-RRB-
cord-254492-42d77vxf	66	18	finger	finger	NN
cord-254492-42d77vxf	66	19	protein-135	protein-135	XX
cord-254492-42d77vxf	67	1	(	(	-LRB-
cord-254492-42d77vxf	67	2	RNF135	RNF135	NNS
cord-254492-42d77vxf	67	3	;	;	:
cord-254492-42d77vxf	67	4	also	also	RB
cord-254492-42d77vxf	67	5	termed	term	VBN
cord-254492-42d77vxf	67	6	Riplet	Riplet	NNP
cord-254492-42d77vxf	67	7	/	/	SYM
cord-254492-42d77vxf	67	8	REUL	REUL	NNP
cord-254492-42d77vxf	67	9	;	;	:
cord-254492-42d77vxf	68	1	Gao	Gao	NNP
cord-254492-42d77vxf	68	2	et	et	NNP
cord-254492-42d77vxf	68	3	al	al	NNP
cord-254492-42d77vxf	68	4	.	.	NNP
cord-254492-42d77vxf	68	5	,	,	,
cord-254492-42d77vxf	68	6	2009	2009	CD
cord-254492-42d77vxf	68	7	)	)	-RRB-
cord-254492-42d77vxf	68	8	,	,	,
cord-254492-42d77vxf	68	9	although	although	IN
cord-254492-42d77vxf	68	10	this	this	DT
cord-254492-42d77vxf	68	11	is	be	VBZ
cord-254492-42d77vxf	68	12	controversial	controversial	JJ
cord-254492-42d77vxf	68	13	(	(	-LRB-
cord-254492-42d77vxf	68	14	Fig	Fig	NNP
cord-254492-42d77vxf	68	15	.	.	.
cord-254492-42d77vxf	68	16	3	3	CD
cord-254492-42d77vxf	68	17	;	;	:
cord-254492-42d77vxf	68	18	Oshiumi	Oshiumi	NNP
cord-254492-42d77vxf	68	19	et	et	NNP
cord-254492-42d77vxf	68	20	al	al	NNP
cord-254492-42d77vxf	68	21	.	.	NNP
cord-254492-42d77vxf	68	22	,	,	,
cord-254492-42d77vxf	68	23	2010	2010	CD
cord-254492-42d77vxf	68	24	)	)	-RRB-
cord-254492-42d77vxf	68	25	.	.	.
cord-254492-42d77vxf	69	1	Underscoring	underscore	VBG
cord-254492-42d77vxf	69	2	the	the	DT
cord-254492-42d77vxf	69	3	importance	importance	NN
cord-254492-42d77vxf	69	4	of	of	IN
cord-254492-42d77vxf	69	5	these	these	DT
cord-254492-42d77vxf	69	6	modifications	modification	NNS
cord-254492-42d77vxf	69	7	,	,	,
cord-254492-42d77vxf	69	8	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	69	9	-	-	HYPH
cord-254492-42d77vxf	69	10	specific	specific	JJ
cord-254492-42d77vxf	69	11	protease	protease	NN
cord-254492-42d77vxf	69	12	3	3	CD
cord-254492-42d77vxf	69	13	(	(	-LRB-
cord-254492-42d77vxf	69	14	USP3	USP3	NNP
cord-254492-42d77vxf	69	15	)	)	-RRB-
cord-254492-42d77vxf	69	16	and	and	CC
cord-254492-42d77vxf	69	17	ubiquitin	ubiquitin	NNP
cord-254492-42d77vxf	69	18	C	C	NNP
cord-254492-42d77vxf	69	19	-	-	HYPH
cord-254492-42d77vxf	69	20	terminal	terminal	NN
cord-254492-42d77vxf	69	21	hydrolase	hydrolase	NN
cord-254492-42d77vxf	69	22	are	be	VBP
cord-254492-42d77vxf	69	23	DUbs	DUbs	NNP
cord-254492-42d77vxf	69	24	that	that	WDT
cord-254492-42d77vxf	69	25	inhibit	inhibit	VBP
cord-254492-42d77vxf	69	26	IFN	IFN	NNP
cord-254492-42d77vxf	69	27	-	-	HYPH
cord-254492-42d77vxf	69	28	I	-PRON-	PRP
cord-254492-42d77vxf	69	29	production	production	NN
cord-254492-42d77vxf	69	30	by	by	IN
cord-254492-42d77vxf	69	31	removing	remove	VBG
cord-254492-42d77vxf	69	32	such	such	JJ
cord-254492-42d77vxf	69	33	chains	chain	NNS
cord-254492-42d77vxf	69	34	from	from	IN
cord-254492-42d77vxf	69	35	RIG	rig	NN
cord-254492-42d77vxf	69	36	-	-	:
cord-254492-42d77vxf	69	37	I	i	NN
cord-254492-42d77vxf	69	38	(	(	-LRB-
cord-254492-42d77vxf	69	39	Friedman	Friedman	NNP
cord-254492-42d77vxf	69	40	et	et	NNP
cord-254492-42d77vxf	69	41	al	al	NNP
cord-254492-42d77vxf	69	42	.	.	NNP
cord-254492-42d77vxf	69	43	,	,	,
cord-254492-42d77vxf	69	44	2008	2008	CD
cord-254492-42d77vxf	69	45	;	;	:
cord-254492-42d77vxf	69	46	Cui	Cui	NNP
cord-254492-42d77vxf	69	47	et	et	FW
cord-254492-42d77vxf	69	48	al	al	NNP
cord-254492-42d77vxf	69	49	.	.	NNP
cord-254492-42d77vxf	69	50	,	,	,
cord-254492-42d77vxf	69	51	2014	2014	CD
cord-254492-42d77vxf	69	52	)	)	-RRB-
cord-254492-42d77vxf	69	53	.	.	.
cord-254492-42d77vxf	70	1	Both	both	DT
cord-254492-42d77vxf	70	2	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	70	3	and	and	CC
cord-254492-42d77vxf	70	4	RNF135	RNF135	NNS
cord-254492-42d77vxf	70	5	are	be	VBP
cord-254492-42d77vxf	70	6	targets	target	NNS
cord-254492-42d77vxf	70	7	of	of	IN
cord-254492-42d77vxf	70	8	the	the	DT
cord-254492-42d77vxf	70	9	influenza	influenza	NN
cord-254492-42d77vxf	70	10	A	a	DT
cord-254492-42d77vxf	70	11	virus	virus	NN
cord-254492-42d77vxf	70	12	(	(	-LRB-
cord-254492-42d77vxf	70	13	IAV	IAV	NNP
cord-254492-42d77vxf	70	14	)	)	-RRB-
cord-254492-42d77vxf	70	15	nonstructural	nonstructural	JJ
cord-254492-42d77vxf	70	16	protein	protein	NN
cord-254492-42d77vxf	70	17	1	1	CD
cord-254492-42d77vxf	70	18	(	(	-LRB-
cord-254492-42d77vxf	70	19	NS1	ns1	CD
cord-254492-42d77vxf	70	20	)	)	-RRB-
cord-254492-42d77vxf	70	21	,	,	,
cord-254492-42d77vxf	70	22	which	which	WDT
cord-254492-42d77vxf	70	23	blocks	block	VBZ
cord-254492-42d77vxf	70	24	their	-PRON-	PRP$
cord-254492-42d77vxf	70	25	E3	e3	NN
cord-254492-42d77vxf	70	26	activity	activity	NN
cord-254492-42d77vxf	70	27	and	and	CC
cord-254492-42d77vxf	70	28	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	70	29	-	-	HYPH
cord-254492-42d77vxf	70	30	dependent	dependent	JJ
cord-254492-42d77vxf	70	31	RIG	rig	NN
cord-254492-42d77vxf	70	32	-	-	:
cord-254492-42d77vxf	70	33	I	-PRON-	PRP
cord-254492-42d77vxf	70	34	activation	activation	NN
cord-254492-42d77vxf	70	35	(	(	-LRB-
cord-254492-42d77vxf	70	36	Fig	Fig	NNP
cord-254492-42d77vxf	70	37	.	.	.
cord-254492-42d77vxf	70	38	3	3	CD
cord-254492-42d77vxf	70	39	;	;	:
cord-254492-42d77vxf	70	40	Gack	Gack	NNP
cord-254492-42d77vxf	70	41	et	et	FW
cord-254492-42d77vxf	70	42	al	al	NNP
cord-254492-42d77vxf	70	43	.	.	.
cord-254492-42d77vxf	71	1	,	,	,
cord-254492-42d77vxf	71	2	2009	2009	CD
cord-254492-42d77vxf	71	3	;	;	:
cord-254492-42d77vxf	71	4	Rajsbaum	Rajsbaum	NNP
cord-254492-42d77vxf	71	5	et	et	NNP
cord-254492-42d77vxf	71	6	al	al	NNP
cord-254492-42d77vxf	71	7	.	.	NNP
cord-254492-42d77vxf	71	8	,	,	,
cord-254492-42d77vxf	71	9	2012	2012	CD
cord-254492-42d77vxf	71	10	)	)	-RRB-
cord-254492-42d77vxf	71	11	.	.	.
cord-254492-42d77vxf	72	1	IAV	IAV	NNP
cord-254492-42d77vxf	72	2	-	-	HYPH
cord-254492-42d77vxf	72	3	NS1	ns1	NN
cord-254492-42d77vxf	72	4	binds	bind	VBZ
cord-254492-42d77vxf	72	5	the	the	DT
cord-254492-42d77vxf	72	6	central	central	JJ
cord-254492-42d77vxf	72	7	coiled	coil	VBN
cord-254492-42d77vxf	72	8	-	-	HYPH
cord-254492-42d77vxf	72	9	coil	coil	NN
cord-254492-42d77vxf	72	10	domain	domain	NN
cord-254492-42d77vxf	72	11	(	(	-LRB-
cord-254492-42d77vxf	72	12	CCD	CCD	NNP
cord-254492-42d77vxf	72	13	)	)	-RRB-
cord-254492-42d77vxf	72	14	of	of	IN
cord-254492-42d77vxf	72	15	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	72	16	and	and	CC
cord-254492-42d77vxf	72	17	is	be	VBZ
cord-254492-42d77vxf	72	18	postulated	postulate	VBN
cord-254492-42d77vxf	72	19	to	to	TO
cord-254492-42d77vxf	72	20	prevent	prevent	VB
cord-254492-42d77vxf	72	21	CCD	ccd	NN
cord-254492-42d77vxf	72	22	-	-	HYPH
cord-254492-42d77vxf	72	23	mediated	mediate	VBN
cord-254492-42d77vxf	72	24	homooligomerization	homooligomerization	NN
cord-254492-42d77vxf	72	25	.	.	.
cord-254492-42d77vxf	73	1	Although	although	IN
cord-254492-42d77vxf	73	2	the	the	DT
cord-254492-42d77vxf	73	3	NS1-binding	ns1-binding	NN
cord-254492-42d77vxf	73	4	site	site	NN
cord-254492-42d77vxf	73	5	on	on	IN
cord-254492-42d77vxf	73	6	RNF135	RNF135	NNS
cord-254492-42d77vxf	73	7	is	be	VBZ
cord-254492-42d77vxf	73	8	unknown	unknown	JJ
cord-254492-42d77vxf	73	9	,	,	,
cord-254492-42d77vxf	73	10	RNF135	RNF135	NNS
cord-254492-42d77vxf	73	11	and	and	CC
cord-254492-42d77vxf	73	12	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	73	13	share	share	VBP
cord-254492-42d77vxf	73	14	a	a	DT
cord-254492-42d77vxf	73	15	similar	similar	JJ
cord-254492-42d77vxf	73	16	RING	ring	NN
cord-254492-42d77vxf	73	17	-	-	HYPH
cord-254492-42d77vxf	73	18	CCD	ccd	NN
cord-254492-42d77vxf	73	19	-	-	HYPH
cord-254492-42d77vxf	73	20	B30.2	B30.2	NNP
cord-254492-42d77vxf	73	21	/	/	SYM
cord-254492-42d77vxf	73	22	SPRY	SPRY	NNP
cord-254492-42d77vxf	73	23	(	(	-LRB-
cord-254492-42d77vxf	73	24	sp1A	sp1A	NNP
cord-254492-42d77vxf	73	25	and	and	CC
cord-254492-42d77vxf	73	26	ryanodine	ryanodine	JJ
cord-254492-42d77vxf	73	27	receptors	receptor	NNS
cord-254492-42d77vxf	73	28	)	)	-RRB-
cord-254492-42d77vxf	73	29	domain	domain	NN
cord-254492-42d77vxf	73	30	Figure	figure	NN
cord-254492-42d77vxf	73	31	2	2	CD
cord-254492-42d77vxf	73	32	.	.	.
cord-254492-42d77vxf	74	1	Schematic	Schematic	NNP
cord-254492-42d77vxf	74	2	of	of	IN
cord-254492-42d77vxf	74	3	the	the	DT
cord-254492-42d77vxf	74	4	TLR	TLR	NNP
cord-254492-42d77vxf	74	5	,	,	,
cord-254492-42d77vxf	74	6	RLR	RLR	NNP
cord-254492-42d77vxf	74	7	,	,	,
cord-254492-42d77vxf	74	8	and	and	CC
cord-254492-42d77vxf	74	9	NLR	NLR	NNP
cord-254492-42d77vxf	74	10	antiviral	antiviral	JJ
cord-254492-42d77vxf	74	11	protein	protein	NN
cord-254492-42d77vxf	74	12	signaling	signal	VBG
cord-254492-42d77vxf	74	13	cascades	cascade	NNS
cord-254492-42d77vxf	74	14	and	and	CC
cord-254492-42d77vxf	74	15	modes	mode	NNS
cord-254492-42d77vxf	74	16	of	of	IN
cord-254492-42d77vxf	74	17	cross	cross	NN
cord-254492-42d77vxf	74	18	-	-	NN
cord-254492-42d77vxf	74	19	talk	talk	NN
cord-254492-42d77vxf	74	20	.	.	.
cord-254492-42d77vxf	75	1	PRRs	PRRs	NNP
cord-254492-42d77vxf	75	2	(	(	-LRB-
cord-254492-42d77vxf	75	3	blue	blue	NNP
cord-254492-42d77vxf	75	4	)	)	-RRB-
cord-254492-42d77vxf	75	5	screen	screen	NN
cord-254492-42d77vxf	75	6	the	the	DT
cord-254492-42d77vxf	75	7	intracellular	intracellular	JJ
cord-254492-42d77vxf	75	8	and	and	CC
cord-254492-42d77vxf	75	9	extracellular	extracellular	JJ
cord-254492-42d77vxf	75	10	environment	environment	NN
cord-254492-42d77vxf	75	11	for	for	IN
cord-254492-42d77vxf	75	12	pathogenic	pathogenic	JJ
cord-254492-42d77vxf	75	13	motifs	motif	NNS
cord-254492-42d77vxf	75	14	.	.	.
cord-254492-42d77vxf	76	1	Ligand	ligand	NN
cord-254492-42d77vxf	76	2	-	-	HYPH
cord-254492-42d77vxf	76	3	activated	activate	VBN
cord-254492-42d77vxf	76	4	PRRs	prr	NNS
cord-254492-42d77vxf	76	5	bind	bind	NN
cord-254492-42d77vxf	76	6	adaptor	adaptor	NN
cord-254492-42d77vxf	76	7	proteins	protein	NNS
cord-254492-42d77vxf	76	8	(	(	-LRB-
cord-254492-42d77vxf	76	9	purple	purple	JJ
cord-254492-42d77vxf	76	10	)	)	-RRB-
cord-254492-42d77vxf	76	11	and	and	CC
cord-254492-42d77vxf	76	12	recruit	recruit	VB
cord-254492-42d77vxf	76	13	protein	protein	NN
cord-254492-42d77vxf	76	14	kinases	kinase	NNS
cord-254492-42d77vxf	76	15	(	(	-LRB-
cord-254492-42d77vxf	76	16	yellow	yellow	JJ
cord-254492-42d77vxf	76	17	)	)	-RRB-
cord-254492-42d77vxf	76	18	and	and	CC
cord-254492-42d77vxf	76	19	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	76	20	-	-	HYPH
cord-254492-42d77vxf	76	21	protein	protein	NN
cord-254492-42d77vxf	76	22	ligases	ligase	NNS
cord-254492-42d77vxf	76	23	(	(	-LRB-
cord-254492-42d77vxf	76	24	green	green	JJ
cord-254492-42d77vxf	76	25	)	)	-RRB-
cord-254492-42d77vxf	76	26	.	.	.
cord-254492-42d77vxf	77	1	These	these	DT
cord-254492-42d77vxf	77	2	regulate	regulate	VBP
cord-254492-42d77vxf	77	3	immune	immune	JJ
cord-254492-42d77vxf	77	4	signal	signal	NN
cord-254492-42d77vxf	77	5	transduction	transduction	NN
cord-254492-42d77vxf	77	6	to	to	IN
cord-254492-42d77vxf	77	7	transcription	transcription	NN
cord-254492-42d77vxf	77	8	factors	factor	NNS
cord-254492-42d77vxf	77	9	(	(	-LRB-
cord-254492-42d77vxf	77	10	orange	orange	NNP
cord-254492-42d77vxf	77	11	)	)	-RRB-
cord-254492-42d77vxf	77	12	through	through	IN
cord-254492-42d77vxf	77	13	PTM	PTM	NNP
cord-254492-42d77vxf	77	14	of	of	IN
cord-254492-42d77vxf	77	15	signaling	signal	VBG
cord-254492-42d77vxf	77	16	cascade	cascade	NN
cord-254492-42d77vxf	77	17	proteins	protein	NNS
cord-254492-42d77vxf	77	18	.	.	.
cord-254492-42d77vxf	78	1	Other	other	JJ
cord-254492-42d77vxf	78	2	regulatory	regulatory	JJ
cord-254492-42d77vxf	78	3	proteins	protein	NNS
cord-254492-42d77vxf	78	4	(	(	-LRB-
cord-254492-42d77vxf	78	5	gray	gray	JJ
cord-254492-42d77vxf	78	6	)	)	-RRB-
cord-254492-42d77vxf	78	7	support	support	NN
cord-254492-42d77vxf	78	8	or	or	CC
cord-254492-42d77vxf	78	9	sequester	sequester	VB
cord-254492-42d77vxf	78	10	these	these	DT
cord-254492-42d77vxf	78	11	signaling	signal	VBG
cord-254492-42d77vxf	78	12	proteins	protein	NNS
cord-254492-42d77vxf	78	13	.	.	.
cord-254492-42d77vxf	79	1	Immune	immune	NN
cord-254492-42d77vxf	79	2	signaling	signal	VBG
cord-254492-42d77vxf	79	3	scaffolds	scaffold	NNS
cord-254492-42d77vxf	79	4	such	such	JJ
cord-254492-42d77vxf	79	5	as	as	IN
cord-254492-42d77vxf	79	6	mitochondria	mitochondrion	NNS
cord-254492-42d77vxf	79	7	typically	typically	RB
cord-254492-42d77vxf	79	8	coordinate	coordinate	VBP
cord-254492-42d77vxf	79	9	these	these	DT
cord-254492-42d77vxf	79	10	actions	action	NNS
cord-254492-42d77vxf	79	11	.	.	.
cord-254492-42d77vxf	80	1	Activated	activate	VBN
cord-254492-42d77vxf	80	2	transcription	transcription	NN
cord-254492-42d77vxf	80	3	factors	factor	NNS
cord-254492-42d77vxf	80	4	translocate	translocate	VBP
cord-254492-42d77vxf	80	5	into	into	IN
cord-254492-42d77vxf	80	6	the	the	DT
cord-254492-42d77vxf	80	7	nucleus	nucleus	NN
cord-254492-42d77vxf	80	8	and	and	CC
cord-254492-42d77vxf	80	9	bind	bind	VB
cord-254492-42d77vxf	80	10	to	to	IN
cord-254492-42d77vxf	80	11	promoter	promoter	NN
cord-254492-42d77vxf	80	12	response	response	NN
cord-254492-42d77vxf	80	13	elements	element	NNS
cord-254492-42d77vxf	80	14	,	,	,
cord-254492-42d77vxf	80	15	stimulating	stimulate	VBG
cord-254492-42d77vxf	80	16	appropriate	appropriate	JJ
cord-254492-42d77vxf	80	17	antiviral	antiviral	JJ
cord-254492-42d77vxf	80	18	gene	gene	NN
cord-254492-42d77vxf	80	19	transcription	transcription	NN
cord-254492-42d77vxf	80	20	.	.	.
cord-254492-42d77vxf	81	1	Blue	blue	JJ
cord-254492-42d77vxf	81	2	and	and	CC
cord-254492-42d77vxf	81	3	green	green	JJ
cord-254492-42d77vxf	81	4	circles	circle	NNS
cord-254492-42d77vxf	81	5	represent	represent	VBP
cord-254492-42d77vxf	81	6	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	81	7	and	and	CC
cord-254492-42d77vxf	81	8	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	81	9	,	,	,
cord-254492-42d77vxf	81	10	respectively	respectively	RB
cord-254492-42d77vxf	81	11	.	.	.
cord-254492-42d77vxf	82	1	Black	black	JJ
cord-254492-42d77vxf	82	2	arrows	arrow	NNS
cord-254492-42d77vxf	82	3	,	,	,
cord-254492-42d77vxf	82	4	activation	activation	NN
cord-254492-42d77vxf	82	5	;	;	:
cord-254492-42d77vxf	82	6	red	red	JJ
cord-254492-42d77vxf	82	7	lines	line	NNS
cord-254492-42d77vxf	82	8	,	,	,
cord-254492-42d77vxf	82	9	deactivation	deactivation	NN
cord-254492-42d77vxf	82	10	.	.	.
cord-254492-42d77vxf	82	11	organization	organization	NN
cord-254492-42d77vxf	82	12	.	.	.
cord-254492-42d77vxf	83	1	However	however	RB
cord-254492-42d77vxf	83	2	,	,	,
cord-254492-42d77vxf	83	3	the	the	DT
cord-254492-42d77vxf	83	4	CCDs	ccd	NNS
cord-254492-42d77vxf	83	5	differ	differ	VBP
cord-254492-42d77vxf	83	6	in	in	IN
cord-254492-42d77vxf	83	7	size	size	NN
cord-254492-42d77vxf	83	8	and	and	CC
cord-254492-42d77vxf	83	9	sequence	sequence	NN
cord-254492-42d77vxf	83	10	markedly	markedly	RB
cord-254492-42d77vxf	83	11	,	,	,
cord-254492-42d77vxf	83	12	suggesting	suggest	VBG
cord-254492-42d77vxf	83	13	that	that	IN
cord-254492-42d77vxf	83	14	IAV	IAV	NNP
cord-254492-42d77vxf	83	15	-	-	HYPH
cord-254492-42d77vxf	83	16	NS1	NS1	NNP
cord-254492-42d77vxf	83	17	may	may	MD
cord-254492-42d77vxf	83	18	bind	bind	VB
cord-254492-42d77vxf	83	19	multiple	multiple	JJ
cord-254492-42d77vxf	83	20	sites	site	NNS
cord-254492-42d77vxf	83	21	on	on	IN
cord-254492-42d77vxf	83	22	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	83	23	and	and	CC
cord-254492-42d77vxf	83	24	RNF135	RNF135	NNS
cord-254492-42d77vxf	83	25	.	.	.
cord-254492-42d77vxf	84	1	Alternatively	alternatively	RB
cord-254492-42d77vxf	84	2	,	,	,
cord-254492-42d77vxf	84	3	given	give	VBN
cord-254492-42d77vxf	84	4	that	that	IN
cord-254492-42d77vxf	84	5	CCDs	ccd	NNS
cord-254492-42d77vxf	84	6	often	often	RB
cord-254492-42d77vxf	84	7	mediate	mediate	VBP
cord-254492-42d77vxf	84	8	protein	protein	NN
cord-254492-42d77vxf	84	9	-	-	HYPH
cord-254492-42d77vxf	84	10	protein	protein	NN
cord-254492-42d77vxf	84	11	interactions	interaction	NNS
cord-254492-42d77vxf	84	12	,	,	,
cord-254492-42d77vxf	84	13	IAV	IAV	NNP
cord-254492-42d77vxf	84	14	-	-	HYPH
cord-254492-42d77vxf	84	15	NS1	ns1	NN
cord-254492-42d77vxf	84	16	may	may	MD
cord-254492-42d77vxf	84	17	sense	sense	VB
cord-254492-42d77vxf	84	18	and	and	CC
cord-254492-42d77vxf	84	19	subvert	subvert	VB
cord-254492-42d77vxf	84	20	CCD	ccd	NN
cord-254492-42d77vxf	84	21	-	-	HYPH
cord-254492-42d77vxf	84	22	interacting	interact	VBG
cord-254492-42d77vxf	84	23	domains	domain	NNS
cord-254492-42d77vxf	84	24	more	more	RBR
cord-254492-42d77vxf	84	25	broadly	broadly	RB
cord-254492-42d77vxf	84	26	.	.	.
cord-254492-42d77vxf	85	1	Notably	notably	RB
cord-254492-42d77vxf	85	2	,	,	,
cord-254492-42d77vxf	85	3	the	the	DT
cord-254492-42d77vxf	85	4	IAV	IAV	NNP
cord-254492-42d77vxf	85	5	-NS1	-ns1	XX
cord-254492-42d77vxf	85	6	:	:	:
cord-254492-42d77vxf	86	1	RNF135	RNF135	NNS
cord-254492-42d77vxf	86	2	interactions	interaction	NNS
cord-254492-42d77vxf	86	3	observed	observe	VBN
cord-254492-42d77vxf	86	4	by	by	IN
cord-254492-42d77vxf	86	5	Rajsbaum	Rajsbaum	NNP
cord-254492-42d77vxf	86	6	et	et	NNP
cord-254492-42d77vxf	86	7	al	al	NNP
cord-254492-42d77vxf	86	8	.	.	.
cord-254492-42d77vxf	87	1	(	(	-LRB-
cord-254492-42d77vxf	87	2	2012	2012	CD
cord-254492-42d77vxf	87	3	)	)	-RRB-
cord-254492-42d77vxf	87	4	were	be	VBD
cord-254492-42d77vxf	87	5	strain	strain	NN
cord-254492-42d77vxf	87	6	dependent	dependent	JJ
cord-254492-42d77vxf	87	7	.	.	.
cord-254492-42d77vxf	88	1	RNF135	RNF135	NNS
cord-254492-42d77vxf	88	2	enables	enable	VBZ
cord-254492-42d77vxf	88	3	RIG-	rig-	PRP
cord-254492-42d77vxf	89	1	I	-PRON-	PRP
cord-254492-42d77vxf	89	2	CARD	card	VBP
cord-254492-42d77vxf	89	3	activation	activation	NN
cord-254492-42d77vxf	89	4	by	by	IN
cord-254492-42d77vxf	89	5	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	89	6	upon	upon	IN
cord-254492-42d77vxf	89	7	ubiquitinating	ubiquitinate	VBG
cord-254492-42d77vxf	89	8	RD	RD	NNP
cord-254492-42d77vxf	89	9	residues	residue	NNS
cord-254492-42d77vxf	89	10	K849	k849	VBP
cord-254492-42d77vxf	89	11	and	and	CC
cord-254492-42d77vxf	89	12	K851	k851	NN
cord-254492-42d77vxf	89	13	.	.	.
cord-254492-42d77vxf	90	1	RNF135	RNF135	NNS
cord-254492-42d77vxf	91	1	knockdown	knockdown	NNP
cord-254492-42d77vxf	91	2	inhibits	inhibit	VBZ
cord-254492-42d77vxf	91	3	interaction	interaction	NN
cord-254492-42d77vxf	91	4	between	between	IN
cord-254492-42d77vxf	91	5	RIG	rig	NN
cord-254492-42d77vxf	91	6	-I	-i	NN
cord-254492-42d77vxf	91	7	:	:	:
cord-254492-42d77vxf	92	1	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	92	2	and	and	CC
cord-254492-42d77vxf	92	3	eliminates	eliminate	VBZ
cord-254492-42d77vxf	92	4	TBK1	TBK1	NNP
cord-254492-42d77vxf	92	5	recruitment	recruitment	NN
cord-254492-42d77vxf	92	6	(	(	-LRB-
cord-254492-42d77vxf	92	7	Oshiumi	Oshiumi	NNP
cord-254492-42d77vxf	92	8	et	et	NNP
cord-254492-42d77vxf	92	9	al	al	NNP
cord-254492-42d77vxf	92	10	.	.	NNP
cord-254492-42d77vxf	92	11	,	,	,
cord-254492-42d77vxf	92	12	2009	2009	CD
cord-254492-42d77vxf	92	13	)	)	-RRB-
cord-254492-42d77vxf	92	14	,	,	,
cord-254492-42d77vxf	92	15	revealing	reveal	VBG
cord-254492-42d77vxf	92	16	an	an	DT
cord-254492-42d77vxf	92	17	ordered	order	VBN
cord-254492-42d77vxf	92	18	functional	functional	JJ
cord-254492-42d77vxf	92	19	interplay	interplay	NN
cord-254492-42d77vxf	92	20	between	between	IN
cord-254492-42d77vxf	92	21	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	92	22	and	and	CC
cord-254492-42d77vxf	92	23	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	92	24	in	in	IN
cord-254492-42d77vxf	92	25	coordinating	coordinate	VBG
cord-254492-42d77vxf	92	26	RIG	rig	NN
cord-254492-42d77vxf	92	27	-	-	:
cord-254492-42d77vxf	92	28	I	-PRON-	PRP
cord-254492-42d77vxf	92	29	activation	activation	NN
cord-254492-42d77vxf	92	30	.	.	.
cord-254492-42d77vxf	93	1	Hepatitis	Hepatitis	NNP
cord-254492-42d77vxf	93	2	C	C	NNP
cord-254492-42d77vxf	93	3	virus	virus	NN
cord-254492-42d77vxf	93	4	(	(	-LRB-
cord-254492-42d77vxf	93	5	HCV	HCV	NNP
cord-254492-42d77vxf	93	6	)	)	-RRB-
cord-254492-42d77vxf	93	7	NS3	ns3	RB
cord-254492-42d77vxf	93	8	-	-	HYPH
cord-254492-42d77vxf	93	9	4A	4a	CD
cord-254492-42d77vxf	93	10	protease	protease	NN
cord-254492-42d77vxf	93	11	exploits	exploit	VBZ
cord-254492-42d77vxf	93	12	this	this	DT
cord-254492-42d77vxf	93	13	concept	concept	NN
cord-254492-42d77vxf	93	14	by	by	IN
cord-254492-42d77vxf	93	15	targeting	target	VBG
cord-254492-42d77vxf	93	16	RNF135	RNF135	NNS
cord-254492-42d77vxf	93	17	for	for	IN
cord-254492-42d77vxf	93	18	proteolytic	proteolytic	JJ
cord-254492-42d77vxf	93	19	cleavage	cleavage	NN
cord-254492-42d77vxf	94	1	(	(	-LRB-
cord-254492-42d77vxf	94	2	Oshiumi	Oshiumi	NNP
cord-254492-42d77vxf	94	3	et	et	NNP
cord-254492-42d77vxf	94	4	al	al	NNP
cord-254492-42d77vxf	94	5	.	.	NNP
cord-254492-42d77vxf	94	6	,	,	,
cord-254492-42d77vxf	94	7	2013	2013	CD
cord-254492-42d77vxf	94	8	)	)	-RRB-
cord-254492-42d77vxf	94	9	.	.	.
cord-254492-42d77vxf	95	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	95	2	,	,	,
cord-254492-42d77vxf	95	3	numerous	numerous	JJ
cord-254492-42d77vxf	95	4	herpesviruses	herpesviruse	NNS
cord-254492-42d77vxf	95	5	encode	encode	VBP
cord-254492-42d77vxf	95	6	their	-PRON-	PRP$
cord-254492-42d77vxf	95	7	own	own	JJ
cord-254492-42d77vxf	95	8	DUbs	DUbs	NNP
cord-254492-42d77vxf	95	9	that	that	WDT
cord-254492-42d77vxf	95	10	inhibit	inhibit	VBP
cord-254492-42d77vxf	95	11	IFN	IFN	NNP
cord-254492-42d77vxf	95	12	-	-	HYPH
cord-254492-42d77vxf	95	13	I	-PRON-	PRP
cord-254492-42d77vxf	95	14	expression	expression	NN
cord-254492-42d77vxf	95	15	by	by	IN
cord-254492-42d77vxf	95	16	stripping	strip	VBG
cord-254492-42d77vxf	95	17	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	95	18	modifications	modification	NNS
cord-254492-42d77vxf	95	19	from	from	IN
cord-254492-42d77vxf	95	20	activated	activate	VBN
cord-254492-42d77vxf	95	21	RIG-	RIG-	NNP
cord-254492-42d77vxf	96	1	I	-PRON-	PRP
cord-254492-42d77vxf	96	2	(	(	-LRB-
cord-254492-42d77vxf	96	3	Inn	Inn	NNP
cord-254492-42d77vxf	96	4	et	et	NNP
cord-254492-42d77vxf	96	5	al	al	NNP
cord-254492-42d77vxf	96	6	.	.	NNP
cord-254492-42d77vxf	96	7	,	,	,
cord-254492-42d77vxf	96	8	2011b	2011b	CD
cord-254492-42d77vxf	96	9	)	)	-RRB-
cord-254492-42d77vxf	96	10	.	.	.
cord-254492-42d77vxf	97	1	Accordingly	accordingly	RB
cord-254492-42d77vxf	97	2	,	,	,
cord-254492-42d77vxf	97	3	HCV	HCV	NNP
cord-254492-42d77vxf	97	4	and	and	CC
cord-254492-42d77vxf	97	5	herpesvirus	herpesvirus	NN
cord-254492-42d77vxf	97	6	infections	infection	NNS
cord-254492-42d77vxf	97	7	are	be	VBP
cord-254492-42d77vxf	97	8	treatable	treatable	JJ
cord-254492-42d77vxf	97	9	with	with	IN
cord-254492-42d77vxf	97	10	IFN	IFN	NNP
cord-254492-42d77vxf	97	11	(	(	-LRB-
cord-254492-42d77vxf	97	12	Oberman	Oberman	NNP
cord-254492-42d77vxf	97	13	and	and	CC
cord-254492-42d77vxf	97	14	Panet	Panet	NNP
cord-254492-42d77vxf	97	15	,	,	,
cord-254492-42d77vxf	97	16	1988	1988	CD
cord-254492-42d77vxf	97	17	;	;	:
cord-254492-42d77vxf	97	18	Nguyen	Nguyen	NNP
cord-254492-42d77vxf	97	19	et	et	NNP
cord-254492-42d77vxf	97	20	al	al	NNP
cord-254492-42d77vxf	97	21	.	.	NNP
cord-254492-42d77vxf	97	22	,	,	,
cord-254492-42d77vxf	97	23	2014	2014	CD
cord-254492-42d77vxf	97	24	)	)	-RRB-
cord-254492-42d77vxf	97	25	,	,	,
cord-254492-42d77vxf	97	26	although	although	IN
cord-254492-42d77vxf	97	27	this	this	DT
cord-254492-42d77vxf	97	28	can	can	MD
cord-254492-42d77vxf	97	29	carry	carry	VB
cord-254492-42d77vxf	97	30	significant	significant	JJ
cord-254492-42d77vxf	97	31	side	side	NN
cord-254492-42d77vxf	97	32	effects	effect	NNS
cord-254492-42d77vxf	97	33	.	.	.
cord-254492-42d77vxf	98	1	Endogenous	endogenous	JJ
cord-254492-42d77vxf	98	2	IFN	IFN	NNP
cord-254492-42d77vxf	98	3	-	-	HYPH
cord-254492-42d77vxf	98	4	I	-PRON-	PRP
cord-254492-42d77vxf	98	5	expression	expression	NN
cord-254492-42d77vxf	98	6	and	and	CC
cord-254492-42d77vxf	98	7	self	self	NN
cord-254492-42d77vxf	98	8	-	-	HYPH
cord-254492-42d77vxf	98	9	regulation	regulation	NN
cord-254492-42d77vxf	98	10	may	may	MD
cord-254492-42d77vxf	98	11	be	be	VB
cord-254492-42d77vxf	98	12	restored	restore	VBN
cord-254492-42d77vxf	98	13	by	by	IN
cord-254492-42d77vxf	98	14	defeating	defeat	VBG
cord-254492-42d77vxf	98	15	such	such	JJ
cord-254492-42d77vxf	98	16	mechanisms	mechanism	NNS
cord-254492-42d77vxf	98	17	of	of	IN
cord-254492-42d77vxf	98	18	viral	viral	JJ
cord-254492-42d77vxf	98	19	antagonism	antagonism	NN
cord-254492-42d77vxf	98	20	.	.	.
cord-254492-42d77vxf	99	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	99	2	in	in	IN
cord-254492-42d77vxf	99	3	the	the	DT
cord-254492-42d77vxf	99	4	return	return	NN
cord-254492-42d77vxf	99	5	to	to	IN
cord-254492-42d77vxf	99	6	homeostasis	homeostasis	NN
cord-254492-42d77vxf	99	7	.	.	.
cord-254492-42d77vxf	100	1	RLR	RLR	NNP
cord-254492-42d77vxf	100	2	signaling	signaling	NN
cord-254492-42d77vxf	100	3	is	be	VBZ
cord-254492-42d77vxf	100	4	also	also	RB
cord-254492-42d77vxf	100	5	counterbalanced	counterbalance	VBN
cord-254492-42d77vxf	100	6	and	and	CC
cord-254492-42d77vxf	100	7	diminished	diminish	VBN
cord-254492-42d77vxf	100	8	through	through	IN
cord-254492-42d77vxf	100	9	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	100	10	modifica-	modifica-	XX
cord-254492-42d77vxf	100	11	tion	tion	NN
cord-254492-42d77vxf	100	12	as	as	IN
cord-254492-42d77vxf	100	13	the	the	DT
cord-254492-42d77vxf	100	14	antiviral	antiviral	JJ
cord-254492-42d77vxf	100	15	posture	posture	NN
cord-254492-42d77vxf	100	16	becomes	become	VBZ
cord-254492-42d77vxf	100	17	unnecessary	unnecessary	JJ
cord-254492-42d77vxf	100	18	.	.	.
cord-254492-42d77vxf	101	1	RNF125	RNF125	NNP
cord-254492-42d77vxf	101	2	forms	form	VBZ
cord-254492-42d77vxf	101	3	part	part	NN
cord-254492-42d77vxf	101	4	of	of	IN
cord-254492-42d77vxf	101	5	this	this	DT
cord-254492-42d77vxf	101	6	process	process	NN
cord-254492-42d77vxf	101	7	,	,	,
cord-254492-42d77vxf	101	8	ligating	ligate	VBG
cord-254492-42d77vxf	101	9	K48-linked	K48-linked	NNP
cord-254492-42d77vxf	101	10	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	101	11	chains	chain	NNS
cord-254492-42d77vxf	101	12	to	to	IN
cord-254492-42d77vxf	101	13	the	the	DT
cord-254492-42d77vxf	101	14	activated	activate	VBN
cord-254492-42d77vxf	101	15	CARD	card	NN
cord-254492-42d77vxf	101	16	of	of	IN
cord-254492-42d77vxf	101	17	RIG	rig	NN
cord-254492-42d77vxf	101	18	-	-	:
cord-254492-42d77vxf	101	19	I	I	NNP
cord-254492-42d77vxf	101	20	and	and	CC
cord-254492-42d77vxf	101	21	MDA5	MDA5	NNP
cord-254492-42d77vxf	101	22	,	,	,
cord-254492-42d77vxf	101	23	leading	lead	VBG
cord-254492-42d77vxf	101	24	to	to	IN
cord-254492-42d77vxf	101	25	proteasome	proteasome	NN
cord-254492-42d77vxf	101	26	-	-	HYPH
cord-254492-42d77vxf	101	27	mediated	mediate	VBN
cord-254492-42d77vxf	101	28	degradation	degradation	NN
cord-254492-42d77vxf	101	29	of	of	IN
cord-254492-42d77vxf	101	30	both	both	DT
cord-254492-42d77vxf	101	31	receptors	receptor	NNS
cord-254492-42d77vxf	101	32	and	and	CC
cord-254492-42d77vxf	101	33	diminished	diminish	VBD
cord-254492-42d77vxf	101	34	IFN	IFN	NNP
cord-254492-42d77vxf	101	35	-	-	HYPH
cord-254492-42d77vxf	101	36	I	I	NNP
cord-254492-42d77vxf	101	37	signaling	signal	VBG
cord-254492-42d77vxf	101	38	.	.	.
cord-254492-42d77vxf	102	1	USP4	USP4	NNP
cord-254492-42d77vxf	102	2	is	be	VBZ
cord-254492-42d77vxf	102	3	a	a	DT
cord-254492-42d77vxf	102	4	DUb	dub	NN
cord-254492-42d77vxf	102	5	that	that	WDT
cord-254492-42d77vxf	102	6	sustains	sustain	VBZ
cord-254492-42d77vxf	102	7	RLR	RLR	NNP
cord-254492-42d77vxf	102	8	signaling	signal	VBG
cord-254492-42d77vxf	102	9	by	by	IN
cord-254492-42d77vxf	102	10	specifically	specifically	RB
cord-254492-42d77vxf	102	11	removing	remove	VBG
cord-254492-42d77vxf	102	12	such	such	JJ
cord-254492-42d77vxf	102	13	chains	chain	NNS
cord-254492-42d77vxf	102	14	(	(	-LRB-
cord-254492-42d77vxf	102	15	Wang	Wang	NNP
cord-254492-42d77vxf	102	16	et	et	NNP
cord-254492-42d77vxf	102	17	al	al	NNP
cord-254492-42d77vxf	102	18	.	.	NNP
cord-254492-42d77vxf	102	19	,	,	,
cord-254492-42d77vxf	102	20	2013a	2013a	CD
cord-254492-42d77vxf	102	21	)	)	-RRB-
cord-254492-42d77vxf	102	22	.	.	.
cord-254492-42d77vxf	103	1	In	in	IN
cord-254492-42d77vxf	103	2	the	the	DT
cord-254492-42d77vxf	103	3	same	same	JJ
cord-254492-42d77vxf	103	4	way	way	NN
cord-254492-42d77vxf	103	5	,	,	,
cord-254492-42d77vxf	103	6	RNF125	RNF125	NNP
cord-254492-42d77vxf	103	7	ubiquitinates	ubiquitinate	NNS
cord-254492-42d77vxf	103	8	and	and	CC
cord-254492-42d77vxf	103	9	degrades	degrade	VBZ
cord-254492-42d77vxf	103	10	activated	activate	VBN
cord-254492-42d77vxf	103	11	MAVS	MAVS	NNP
cord-254492-42d77vxf	103	12	(	(	-LRB-
cord-254492-42d77vxf	103	13	Arimoto	Arimoto	NNP
cord-254492-42d77vxf	103	14	et	et	NNP
cord-254492-42d77vxf	103	15	al	al	NNP
cord-254492-42d77vxf	103	16	.	.	NNP
cord-254492-42d77vxf	103	17	,	,	,
cord-254492-42d77vxf	103	18	2007	2007	CD
cord-254492-42d77vxf	103	19	)	)	-RRB-
cord-254492-42d77vxf	103	20	,	,	,
cord-254492-42d77vxf	103	21	suggesting	suggest	VBG
cord-254492-42d77vxf	103	22	that	that	IN
cord-254492-42d77vxf	103	23	RNF125	RNF125	NNP
cord-254492-42d77vxf	103	24	is	be	VBZ
cord-254492-42d77vxf	103	25	an	an	DT
cord-254492-42d77vxf	103	26	E3	e3	NN
cord-254492-42d77vxf	103	27	that	that	WDT
cord-254492-42d77vxf	103	28	destabilizes	destabilize	VBZ
cord-254492-42d77vxf	103	29	proteins	protein	NNS
cord-254492-42d77vxf	103	30	containing	contain	VBG
cord-254492-42d77vxf	103	31	activated	activate	VBN
cord-254492-42d77vxf	103	32	CARDs	card	NNS
cord-254492-42d77vxf	103	33	.	.	.
cord-254492-42d77vxf	104	1	Given	give	VBN
cord-254492-42d77vxf	104	2	how	how	WRB
cord-254492-42d77vxf	104	3	commonly	commonly	RB
cord-254492-42d77vxf	104	4	CARD	card	NN
cord-254492-42d77vxf	104	5	-	-	HYPH
cord-254492-42d77vxf	104	6	containing	contain	VBG
cord-254492-42d77vxf	104	7	proteins	protein	NNS
cord-254492-42d77vxf	104	8	and	and	CC
cord-254492-42d77vxf	104	9	their	-PRON-	PRP$
cord-254492-42d77vxf	104	10	homotypic	homotypic	JJ
cord-254492-42d77vxf	104	11	interactions	interaction	NNS
cord-254492-42d77vxf	104	12	feature	feature	VBP
cord-254492-42d77vxf	104	13	in	in	IN
cord-254492-42d77vxf	104	14	immune	immune	JJ
cord-254492-42d77vxf	104	15	signaling	signal	VBG
cord-254492-42d77vxf	104	16	pathways	pathway	NNS
cord-254492-42d77vxf	105	1	(	(	-LRB-
cord-254492-42d77vxf	105	2	Bouchier	Bouchier	NNP
cord-254492-42d77vxf	105	3	-	-	HYPH
cord-254492-42d77vxf	105	4	Hayes	Hayes	NNP
cord-254492-42d77vxf	105	5	and	and	CC
cord-254492-42d77vxf	105	6	Martin	Martin	NNP
cord-254492-42d77vxf	105	7	,	,	,
cord-254492-42d77vxf	105	8	2002	2002	CD
cord-254492-42d77vxf	105	9	)	)	-RRB-
cord-254492-42d77vxf	105	10	,	,	,
cord-254492-42d77vxf	105	11	RNF125	RNF125	NNP
cord-254492-42d77vxf	105	12	may	may	MD
cord-254492-42d77vxf	105	13	represent	represent	VB
cord-254492-42d77vxf	105	14	a	a	DT
cord-254492-42d77vxf	105	15	general	general	JJ
cord-254492-42d77vxf	105	16	immune	immune	NN
cord-254492-42d77vxf	105	17	signaling	signal	VBG
cord-254492-42d77vxf	105	18	antagonist	antagonist	NN
cord-254492-42d77vxf	105	19	.	.	.
cord-254492-42d77vxf	106	1	Conversely	conversely	RB
cord-254492-42d77vxf	106	2	,	,	,
cord-254492-42d77vxf	106	3	the	the	DT
cord-254492-42d77vxf	106	4	52-kD	52-kd	CD
cord-254492-42d77vxf	106	5	repressor	repressor	NN
cord-254492-42d77vxf	106	6	of	of	IN
cord-254492-42d77vxf	106	7	the	the	DT
cord-254492-42d77vxf	106	8	inhibitor	inhibitor	NN
cord-254492-42d77vxf	106	9	of	of	IN
cord-254492-42d77vxf	106	10	the	the	DT
cord-254492-42d77vxf	106	11	protein	protein	NN
cord-254492-42d77vxf	106	12	kinase	kinase	NN
cord-254492-42d77vxf	106	13	(	(	-LRB-
cord-254492-42d77vxf	106	14	p52rIPK	p52ripk	NN
cord-254492-42d77vxf	106	15	)	)	-RRB-
cord-254492-42d77vxf	106	16	binds	bind	VBZ
cord-254492-42d77vxf	106	17	and	and	CC
cord-254492-42d77vxf	106	18	enhances	enhance	VBZ
cord-254492-42d77vxf	106	19	the	the	DT
cord-254492-42d77vxf	106	20	stability	stability	NN
cord-254492-42d77vxf	106	21	of	of	IN
cord-254492-42d77vxf	106	22	RIG	rig	NN
cord-254492-42d77vxf	107	1	-I	-i	WDT
cord-254492-42d77vxf	107	2	by	by	IN
cord-254492-42d77vxf	107	3	blocking	block	VBG
cord-254492-42d77vxf	107	4	its	-PRON-	PRP$
cord-254492-42d77vxf	107	5	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	107	6	-	-	HYPH
cord-254492-42d77vxf	107	7	mediated	mediate	VBN
cord-254492-42d77vxf	107	8	degradation	degradation	NN
cord-254492-42d77vxf	107	9	(	(	-LRB-
cord-254492-42d77vxf	107	10	Now	now	RB
cord-254492-42d77vxf	107	11	and	and	CC
cord-254492-42d77vxf	107	12	Yoo	Yoo	NNP
cord-254492-42d77vxf	107	13	,	,	,
cord-254492-42d77vxf	107	14	2011	2011	CD
cord-254492-42d77vxf	107	15	)	)	-RRB-
cord-254492-42d77vxf	107	16	.	.	.
cord-254492-42d77vxf	108	1	Accordingly	accordingly	RB
cord-254492-42d77vxf	108	2	,	,	,
cord-254492-42d77vxf	108	3	the	the	DT
cord-254492-42d77vxf	108	4	properties	property	NNS
cord-254492-42d77vxf	108	5	of	of	IN
cord-254492-42d77vxf	108	6	p52rIPK	p52ripk	JJ
cord-254492-42d77vxf	108	7	or	or	CC
cord-254492-42d77vxf	108	8	RNF125	RNF125	NNP
cord-254492-42d77vxf	108	9	may	may	MD
cord-254492-42d77vxf	108	10	be	be	VB
cord-254492-42d77vxf	108	11	exploitable	exploitable	JJ
cord-254492-42d77vxf	108	12	in	in	IN
cord-254492-42d77vxf	108	13	the	the	DT
cord-254492-42d77vxf	108	14	treatment	treatment	NN
cord-254492-42d77vxf	108	15	of	of	IN
cord-254492-42d77vxf	108	16	viral	viral	JJ
cord-254492-42d77vxf	108	17	infections	infection	NNS
cord-254492-42d77vxf	108	18	or	or	CC
cord-254492-42d77vxf	108	19	autoimmune	autoimmune	JJ
cord-254492-42d77vxf	108	20	disorders	disorder	NNS
cord-254492-42d77vxf	108	21	.	.	.
cord-254492-42d77vxf	109	1	The	the	DT
cord-254492-42d77vxf	109	2	linear	linear	JJ
cord-254492-42d77vxf	109	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	109	4	assembly	assembly	NN
cord-254492-42d77vxf	109	5	complex	complex	NN
cord-254492-42d77vxf	109	6	(	(	-LRB-
cord-254492-42d77vxf	109	7	LUB	LUB	NNP
cord-254492-42d77vxf	109	8	AC	AC	NNP
cord-254492-42d77vxf	109	9	)	)	-RRB-
cord-254492-42d77vxf	109	10	,	,	,
cord-254492-42d77vxf	109	11	containing	contain	VBG
cord-254492-42d77vxf	109	12	SHA	SHA	NNP
cord-254492-42d77vxf	109	13	NK	NK	NNP
cord-254492-42d77vxf	109	14	-	-	HYPH
cord-254492-42d77vxf	109	15	associated	associate	VBN
cord-254492-42d77vxf	109	16	RH	RH	NNP
cord-254492-42d77vxf	109	17	domain	domain	NN
cord-254492-42d77vxf	109	18	-	-	HYPH
cord-254492-42d77vxf	109	19	interacting	interact	VBG
cord-254492-42d77vxf	109	20	protein	protein	NN
cord-254492-42d77vxf	109	21	(	(	-LRB-
cord-254492-42d77vxf	109	22	SHA	SHA	NNP
cord-254492-42d77vxf	109	23	RPIN	RPIN	NNPS
cord-254492-42d77vxf	109	24	)	)	-RRB-
cord-254492-42d77vxf	109	25	,	,	,
cord-254492-42d77vxf	109	26	heme	heme	NN
cord-254492-42d77vxf	109	27	-	-	HYPH
cord-254492-42d77vxf	109	28	oxidized	oxidize	VBN
cord-254492-42d77vxf	109	29	IRP2	IRP2	NNP
cord-254492-42d77vxf	109	30	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	109	31	ligase	ligase	NN
cord-254492-42d77vxf	109	32	1L	1l	CD
cord-254492-42d77vxf	109	33	(	(	-LRB-
cord-254492-42d77vxf	109	34	HOIL-1L	HOIL-1L	NNP
cord-254492-42d77vxf	109	35	)	)	-RRB-
cord-254492-42d77vxf	109	36	,	,	,
cord-254492-42d77vxf	109	37	and	and	CC
cord-254492-42d77vxf	109	38	HOIL-1-interacting	hoil-1-interacte	VBG
cord-254492-42d77vxf	109	39	protein	protein	NN
cord-254492-42d77vxf	109	40	(	(	-LRB-
cord-254492-42d77vxf	109	41	HOIP	HOIP	NNP
cord-254492-42d77vxf	109	42	)	)	-RRB-
cord-254492-42d77vxf	109	43	,	,	,
cord-254492-42d77vxf	109	44	was	be	VBD
cord-254492-42d77vxf	109	45	proposed	propose	VBN
cord-254492-42d77vxf	109	46	to	to	TO
cord-254492-42d77vxf	109	47	negatively	negatively	RB
cord-254492-42d77vxf	109	48	regulate	regulate	VB
cord-254492-42d77vxf	109	49	RLR	RLR	NNP
cord-254492-42d77vxf	109	50	-	-	HYPH
cord-254492-42d77vxf	109	51	mediated	mediate	VBN
cord-254492-42d77vxf	109	52	IFN	IFN	NNP
cord-254492-42d77vxf	109	53	-	-	HYPH
cord-254492-42d77vxf	109	54	I	-PRON-	PRP
cord-254492-42d77vxf	109	55	expression	expression	NN
cord-254492-42d77vxf	109	56	via	via	IN
cord-254492-42d77vxf	109	57	two	two	CD
cord-254492-42d77vxf	109	58	independent	independent	JJ
cord-254492-42d77vxf	109	59	mechanisms	mechanism	NNS
cord-254492-42d77vxf	109	60	(	(	-LRB-
cord-254492-42d77vxf	109	61	Inn	Inn	NNP
cord-254492-42d77vxf	109	62	et	et	NNP
cord-254492-42d77vxf	109	63	al	al	NNP
cord-254492-42d77vxf	109	64	.	.	NNP
cord-254492-42d77vxf	109	65	,	,	,
cord-254492-42d77vxf	109	66	2011a	2011a	CD
cord-254492-42d77vxf	109	67	)	)	-RRB-
cord-254492-42d77vxf	109	68	.	.	.
cord-254492-42d77vxf	110	1	First	first	RB
cord-254492-42d77vxf	110	2	,	,	,
cord-254492-42d77vxf	110	3	HOIL-1L	HOIL-1L	NNP
cord-254492-42d77vxf	110	4	competes	compete	VBZ
cord-254492-42d77vxf	110	5	with	with	IN
cord-254492-42d77vxf	110	6	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	110	7	for	for	IN
cord-254492-42d77vxf	110	8	RIG-	RIG-	NNP
cord-254492-42d77vxf	111	1	I	-PRON-	PRP
cord-254492-42d77vxf	111	2	CARD	card	VBP
cord-254492-42d77vxf	111	3	binding	bind	VBG
cord-254492-42d77vxf	111	4	,	,	,
cord-254492-42d77vxf	111	5	abrogating	abrogate	VBG
cord-254492-42d77vxf	111	6	the	the	DT
cord-254492-42d77vxf	111	7	RIG	rig	NN
cord-254492-42d77vxf	111	8	-I	-i	NN
cord-254492-42d77vxf	111	9	:	:	:
cord-254492-42d77vxf	111	10	MAVS	mavs	RB
cord-254492-42d77vxf	111	11	interaction	interaction	NN
cord-254492-42d77vxf	111	12	.	.	.
cord-254492-42d77vxf	112	1	Second	second	RB
cord-254492-42d77vxf	112	2	,	,	,
cord-254492-42d77vxf	112	3	HOIP	HOIP	NNP
cord-254492-42d77vxf	112	4	promotes	promote	VBZ
cord-254492-42d77vxf	112	5	M1-and	m1-and	NN
cord-254492-42d77vxf	112	6	K48-linked	K48-linked	NNP
cord-254492-42d77vxf	112	7	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	112	8	of	of	IN
cord-254492-42d77vxf	112	9	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	112	10	and	and	CC
cord-254492-42d77vxf	112	11	induces	induce	VBZ
cord-254492-42d77vxf	112	12	its	-PRON-	PRP$
cord-254492-42d77vxf	112	13	proteasomal	proteasomal	JJ
cord-254492-42d77vxf	112	14	degradation	degradation	NN
cord-254492-42d77vxf	112	15	,	,	,
cord-254492-42d77vxf	112	16	thereby	thereby	RB
cord-254492-42d77vxf	112	17	decreasing	decrease	VBG
cord-254492-42d77vxf	112	18	TRIM25-mediated	trim25-mediated	JJ
cord-254492-42d77vxf	112	19	activation	activation	NN
cord-254492-42d77vxf	112	20	of	of	IN
cord-254492-42d77vxf	112	21	RIG	rig	NN
cord-254492-42d77vxf	112	22	-	-	HYPH
cord-254492-42d77vxf	112	23	I.	i.	NN
cord-254492-42d77vxf	112	24	If	if	IN
cord-254492-42d77vxf	112	25	LUB	LUB	NNP
cord-254492-42d77vxf	112	26	AC	AC	NNP
cord-254492-42d77vxf	112	27	were	be	VBD
cord-254492-42d77vxf	112	28	capable	capable	JJ
cord-254492-42d77vxf	112	29	of	of	IN
cord-254492-42d77vxf	112	30	ligating	ligate	VBG
cord-254492-42d77vxf	112	31	K48-linked	K48-linked	NNP
cord-254492-42d77vxf	112	32	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	112	33	chains	chain	NNS
cord-254492-42d77vxf	112	34	to	to	IN
cord-254492-42d77vxf	112	35	substrates	substrate	NNS
cord-254492-42d77vxf	112	36	,	,	,
cord-254492-42d77vxf	112	37	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	112	38	would	would	MD
cord-254492-42d77vxf	112	39	be	be	VB
cord-254492-42d77vxf	112	40	the	the	DT
cord-254492-42d77vxf	112	41	first	first	JJ
cord-254492-42d77vxf	112	42	example	example	NN
cord-254492-42d77vxf	112	43	to	to	IN
cord-254492-42d77vxf	112	44	our	-PRON-	PRP$
cord-254492-42d77vxf	112	45	knowledge	knowledge	NN
cord-254492-42d77vxf	112	46	.	.	.
cord-254492-42d77vxf	113	1	Another	another	DT
cord-254492-42d77vxf	113	2	route	route	NN
cord-254492-42d77vxf	113	3	of	of	IN
cord-254492-42d77vxf	113	4	RLR	RLR	NNP
cord-254492-42d77vxf	113	5	inhibition	inhibition	NN
cord-254492-42d77vxf	113	6	involves	involve	VBZ
cord-254492-42d77vxf	113	7	tetraspanin-6	tetraspanin-6	VBN
cord-254492-42d77vxf	113	8	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	113	9	by	by	IN
cord-254492-42d77vxf	113	10	an	an	DT
cord-254492-42d77vxf	113	11	unknown	unknown	JJ
cord-254492-42d77vxf	113	12	E3	e3	NN
cord-254492-42d77vxf	113	13	.	.	.
cord-254492-42d77vxf	114	1	During	during	IN
cord-254492-42d77vxf	114	2	RLR	RLR	NNP
cord-254492-42d77vxf	114	3	activation	activation	NN
cord-254492-42d77vxf	114	4	,	,	,
cord-254492-42d77vxf	114	5	polyubiquitinated	polyubiquitinate	VBD
cord-254492-42d77vxf	114	6	tetraspanin-6	tetraspanin-6	NNP
cord-254492-42d77vxf	114	7	is	be	VBZ
cord-254492-42d77vxf	114	8	recruited	recruit	VBN
cord-254492-42d77vxf	114	9	to	to	IN
cord-254492-42d77vxf	114	10	MAVS	MAVS	NNP
cord-254492-42d77vxf	114	11	and	and	CC
cord-254492-42d77vxf	114	12	blocks	block	VBZ
cord-254492-42d77vxf	114	13	the	the	DT
cord-254492-42d77vxf	114	14	RLR	RLR	NNP
cord-254492-42d77vxf	114	15	:	:	:
cord-254492-42d77vxf	114	16	MAVS	MAVS	NNP
cord-254492-42d77vxf	114	17	interaction	interaction	NN
cord-254492-42d77vxf	114	18	,	,	,
cord-254492-42d77vxf	114	19	thereby	thereby	RB
cord-254492-42d77vxf	114	20	impeding	impede	VBG
cord-254492-42d77vxf	114	21	recruitment	recruitment	NN
cord-254492-42d77vxf	114	22	of	of	IN
cord-254492-42d77vxf	114	23	the	the	DT
cord-254492-42d77vxf	114	24	downstream	downstream	JJ
cord-254492-42d77vxf	114	25	signaling	signaling	NN
cord-254492-42d77vxf	114	26	apparatus	apparatus	NN
cord-254492-42d77vxf	114	27	(	(	-LRB-
cord-254492-42d77vxf	114	28	Wang	Wang	NNP
cord-254492-42d77vxf	114	29	et	et	NNP
cord-254492-42d77vxf	114	30	al	al	NNP
cord-254492-42d77vxf	114	31	.	.	NNP
cord-254492-42d77vxf	114	32	,	,	,
cord-254492-42d77vxf	114	33	2012b	2012b	CD
cord-254492-42d77vxf	114	34	)	)	-RRB-
cord-254492-42d77vxf	114	35	.	.	.
cord-254492-42d77vxf	115	1	Mitochondria	mitochondrion	NNS
cord-254492-42d77vxf	115	2	,	,	,
cord-254492-42d77vxf	115	3	peroxisomes	peroxisome	NNS
cord-254492-42d77vxf	115	4	,	,	,
cord-254492-42d77vxf	115	5	and	and	CC
cord-254492-42d77vxf	115	6	endoplasmic	endoplasmic	NN
cord-254492-42d77vxf	115	7	reticulum	reticulum	NN
cord-254492-42d77vxf	115	8	function	function	NN
cord-254492-42d77vxf	115	9	as	as	IN
cord-254492-42d77vxf	115	10	immune	immune	JJ
cord-254492-42d77vxf	115	11	signaling	signal	VBG
cord-254492-42d77vxf	115	12	platforms	platform	NNS
cord-254492-42d77vxf	115	13	linking	link	VBG
cord-254492-42d77vxf	115	14	viral	viral	JJ
cord-254492-42d77vxf	115	15	pattern	pattern	NN
cord-254492-42d77vxf	115	16	recognition	recognition	NN
cord-254492-42d77vxf	115	17	with	with	IN
cord-254492-42d77vxf	115	18	effector	effector	NN
cord-254492-42d77vxf	115	19	molecule	molecule	NN
cord-254492-42d77vxf	115	20	production	production	NN
cord-254492-42d77vxf	115	21	(	(	-LRB-
cord-254492-42d77vxf	115	22	Fig	Fig	NNP
cord-254492-42d77vxf	115	23	.	.	NNP
cord-254492-42d77vxf	115	24	2	2	CD
cord-254492-42d77vxf	115	25	,	,	,
cord-254492-42d77vxf	115	26	middle	middle	JJ
cord-254492-42d77vxf	115	27	)	)	-RRB-
cord-254492-42d77vxf	115	28	.	.	.
cord-254492-42d77vxf	116	1	Although	although	IN
cord-254492-42d77vxf	116	2	this	this	DT
cord-254492-42d77vxf	116	3	process	process	NN
cord-254492-42d77vxf	116	4	remains	remain	VBZ
cord-254492-42d77vxf	116	5	poorly	poorly	RB
cord-254492-42d77vxf	116	6	characterized	characterize	VBN
cord-254492-42d77vxf	116	7	,	,	,
cord-254492-42d77vxf	116	8	the	the	DT
cord-254492-42d77vxf	116	9	nature	nature	NN
cord-254492-42d77vxf	116	10	and	and	CC
cord-254492-42d77vxf	116	11	context	context	NN
cord-254492-42d77vxf	116	12	of	of	IN
cord-254492-42d77vxf	116	13	viral	viral	JJ
cord-254492-42d77vxf	116	14	ligands	ligand	NNS
cord-254492-42d77vxf	116	15	detected	detect	VBN
cord-254492-42d77vxf	116	16	by	by	IN
cord-254492-42d77vxf	116	17	PRRs	PRRs	NNP
cord-254492-42d77vxf	116	18	drives	drive	VBZ
cord-254492-42d77vxf	116	19	accumulation	accumulation	NN
cord-254492-42d77vxf	116	20	of	of	IN
cord-254492-42d77vxf	116	21	the	the	DT
cord-254492-42d77vxf	116	22	downstream	downstream	JJ
cord-254492-42d77vxf	116	23	signaling	signaling	NN
cord-254492-42d77vxf	116	24	apparatus	apparatus	NN
cord-254492-42d77vxf	116	25	to	to	IN
cord-254492-42d77vxf	116	26	these	these	DT
cord-254492-42d77vxf	116	27	platforms	platform	NNS
cord-254492-42d77vxf	116	28	.	.	.
cord-254492-42d77vxf	117	1	Adaptor	adaptor	NN
cord-254492-42d77vxf	117	2	proteins	protein	NNS
cord-254492-42d77vxf	117	3	mediate	mediate	VBP
cord-254492-42d77vxf	117	4	this	this	DT
cord-254492-42d77vxf	117	5	accumulation	accumulation	NN
cord-254492-42d77vxf	117	6	:	:	:
cord-254492-42d77vxf	118	1	mitochondria	mitochondrion	NNS
cord-254492-42d77vxf	118	2	and	and	CC
cord-254492-42d77vxf	118	3	peroxisomes	peroxisome	NNS
cord-254492-42d77vxf	118	4	by	by	IN
cord-254492-42d77vxf	118	5	MAVS	MAVS	NNP
cord-254492-42d77vxf	119	1	(	(	-LRB-
cord-254492-42d77vxf	119	2	Dixit	Dixit	NNP
cord-254492-42d77vxf	119	3	et	et	FW
cord-254492-42d77vxf	119	4	al	al	NNP
cord-254492-42d77vxf	119	5	.	.	NNP
cord-254492-42d77vxf	119	6	,	,	,
cord-254492-42d77vxf	119	7	2010	2010	CD
cord-254492-42d77vxf	119	8	)	)	-RRB-
cord-254492-42d77vxf	119	9	and	and	CC
cord-254492-42d77vxf	119	10	endoplasmic	endoplasmic	NN
cord-254492-42d77vxf	119	11	reticulum	reticulum	NN
cord-254492-42d77vxf	119	12	by	by	IN
cord-254492-42d77vxf	119	13	stimulator	stimulator	NN
cord-254492-42d77vxf	119	14	of	of	IN
cord-254492-42d77vxf	119	15	IFN	IFN	NNP
cord-254492-42d77vxf	119	16	genes	gene	NNS
cord-254492-42d77vxf	119	17	(	(	-LRB-
cord-254492-42d77vxf	119	18	STI	STI	NNP
cord-254492-42d77vxf	119	19	NG	NG	NNP
cord-254492-42d77vxf	119	20	;	;	:
cord-254492-42d77vxf	119	21	Ishikawa	Ishikawa	NNP
cord-254492-42d77vxf	119	22	and	and	CC
cord-254492-42d77vxf	119	23	Barber	Barber	NNP
cord-254492-42d77vxf	119	24	,	,	,
cord-254492-42d77vxf	119	25	2008	2008	CD
cord-254492-42d77vxf	119	26	)	)	-RRB-
cord-254492-42d77vxf	119	27	.	.	.
cord-254492-42d77vxf	120	1	Cyclic	cyclic	JJ
cord-254492-42d77vxf	120	2	GMP	GMP	NNP
cord-254492-42d77vxf	120	3	-	-	HYPH
cord-254492-42d77vxf	120	4	AMP	AMP	NNP
cord-254492-42d77vxf	120	5	synthase	synthase	NN
cord-254492-42d77vxf	120	6	(	(	-LRB-
cord-254492-42d77vxf	120	7	cGAS	cGAS	NNP
cord-254492-42d77vxf	120	8	)	)	-RRB-
cord-254492-42d77vxf	120	9	and	and	CC
cord-254492-42d77vxf	120	10	AIM2-like	aim2-like	IN
cord-254492-42d77vxf	120	11	receptors	receptor	NNS
cord-254492-42d77vxf	120	12	(	(	-LRB-
cord-254492-42d77vxf	120	13	ALRs	ALRs	NNP
cord-254492-42d77vxf	120	14	)	)	-RRB-
cord-254492-42d77vxf	120	15	,	,	,
cord-254492-42d77vxf	120	16	which	which	WDT
cord-254492-42d77vxf	120	17	include	include	VBP
cord-254492-42d77vxf	120	18	AIM2	AIM2	NNP
cord-254492-42d77vxf	120	19	and	and	CC
cord-254492-42d77vxf	120	20	human	human	JJ
cord-254492-42d77vxf	120	21	IFN	IFN	NNP
cord-254492-42d77vxf	120	22	-	-	HYPH
cord-254492-42d77vxf	120	23	inducible	inducible	JJ
cord-254492-42d77vxf	120	24	protein	protein	NN
cord-254492-42d77vxf	120	25	16	16	CD
cord-254492-42d77vxf	120	26	(	(	-LRB-
cord-254492-42d77vxf	120	27	IFI16	IFI16	NNP
cord-254492-42d77vxf	120	28	)	)	-RRB-
cord-254492-42d77vxf	120	29	,	,	,
cord-254492-42d77vxf	120	30	have	have	VBP
cord-254492-42d77vxf	120	31	also	also	RB
cord-254492-42d77vxf	120	32	emerged	emerge	VBN
cord-254492-42d77vxf	120	33	as	as	IN
cord-254492-42d77vxf	120	34	important	important	JJ
cord-254492-42d77vxf	120	35	DNA	dna	NN
cord-254492-42d77vxf	120	36	virus	virus	NN
cord-254492-42d77vxf	120	37	PRRs	prr	NNS
cord-254492-42d77vxf	120	38	.	.	.
cord-254492-42d77vxf	121	1	cGAS	cgas	JJ
cord-254492-42d77vxf	121	2	signals	signal	NNS
cord-254492-42d77vxf	121	3	via	via	IN
cord-254492-42d77vxf	121	4	STI	STI	NNP
cord-254492-42d77vxf	121	5	NG	NG	NNP
cord-254492-42d77vxf	121	6	and	and	CC
cord-254492-42d77vxf	121	7	AIM2	AIM2	NNP
cord-254492-42d77vxf	121	8	generates	generate	VBZ
cord-254492-42d77vxf	121	9	inflammasome	inflammasome	NN
cord-254492-42d77vxf	121	10	oligomers	oligomer	NNS
cord-254492-42d77vxf	121	11	,	,	,
cord-254492-42d77vxf	121	12	whereas	whereas	IN
cord-254492-42d77vxf	121	13	IFI16	ifi16	NN
cord-254492-42d77vxf	121	14	can	can	MD
cord-254492-42d77vxf	121	15	stimulate	stimulate	VB
cord-254492-42d77vxf	121	16	both	both	DT
cord-254492-42d77vxf	121	17	signaling	signal	VBG
cord-254492-42d77vxf	121	18	mechanisms	mechanism	NNS
cord-254492-42d77vxf	121	19	(	(	-LRB-
cord-254492-42d77vxf	121	20	Diner	Diner	NNP
cord-254492-42d77vxf	121	21	et	et	NNP
cord-254492-42d77vxf	121	22	al	al	NNP
cord-254492-42d77vxf	121	23	.	.	NNP
cord-254492-42d77vxf	121	24	,	,	,
cord-254492-42d77vxf	121	25	2015	2015	CD
cord-254492-42d77vxf	121	26	)	)	-RRB-
cord-254492-42d77vxf	121	27	.	.	.
cord-254492-42d77vxf	122	1	RNA	RNA	NNP
cord-254492-42d77vxf	122	2	-	-	HYPH
cord-254492-42d77vxf	122	3	activated	activate	VBN
cord-254492-42d77vxf	122	4	RIG	rig	NN
cord-254492-42d77vxf	122	5	-	-	:
cord-254492-42d77vxf	122	6	I	I	NNP
cord-254492-42d77vxf	122	7	and	and	CC
cord-254492-42d77vxf	122	8	MDA5	mda5	JJ
cord-254492-42d77vxf	122	9	colocalize	colocalize	NN
cord-254492-42d77vxf	122	10	with	with	IN
cord-254492-42d77vxf	122	11	MAVS	MAVS	NNPS
cord-254492-42d77vxf	122	12	,	,	,
cord-254492-42d77vxf	122	13	inducing	induce	VBG
cord-254492-42d77vxf	122	14	its	-PRON-	PRP$
cord-254492-42d77vxf	122	15	filamentation	filamentation	NN
cord-254492-42d77vxf	122	16	.	.	.
cord-254492-42d77vxf	123	1	It	-PRON-	PRP
cord-254492-42d77vxf	123	2	remains	remain	VBZ
cord-254492-42d77vxf	123	3	unclear	unclear	JJ
cord-254492-42d77vxf	123	4	why	why	WRB
cord-254492-42d77vxf	123	5	these	these	DT
cord-254492-42d77vxf	123	6	filaments	filament	NNS
cord-254492-42d77vxf	123	7	are	be	VBP
cord-254492-42d77vxf	123	8	potent	potent	JJ
cord-254492-42d77vxf	123	9	inducers	inducer	NNS
cord-254492-42d77vxf	123	10	of	of	IN
cord-254492-42d77vxf	123	11	downstream	downstream	JJ
cord-254492-42d77vxf	123	12	signaling	signaling	NN
cord-254492-42d77vxf	123	13	;	;	:
cord-254492-42d77vxf	123	14	however	however	RB
cord-254492-42d77vxf	123	15	,	,	,
cord-254492-42d77vxf	123	16	RLR	RLR	NNP
cord-254492-42d77vxf	123	17	cascade	cascade	NN
cord-254492-42d77vxf	123	18	proteins	protein	NNS
cord-254492-42d77vxf	123	19	including	include	VBG
cord-254492-42d77vxf	123	20	NEMO	NEMO	NNP
cord-254492-42d77vxf	123	21	,	,	,
cord-254492-42d77vxf	123	22	IKKε	IKKε	NNS
cord-254492-42d77vxf	123	23	,	,	,
cord-254492-42d77vxf	123	24	and	and	CC
cord-254492-42d77vxf	123	25	various	various	JJ
cord-254492-42d77vxf	123	26	TRAFs	traf	NNS
cord-254492-42d77vxf	123	27	possess	possess	VBP
cord-254492-42d77vxf	123	28	MAVS	mavs	RB
cord-254492-42d77vxf	123	29	-	-	HYPH
cord-254492-42d77vxf	123	30	targeting	target	VBG
cord-254492-42d77vxf	123	31	signals	signal	NNS
cord-254492-42d77vxf	124	1	(	(	-LRB-
cord-254492-42d77vxf	124	2	Paz	Paz	NNP
cord-254492-42d77vxf	124	3	et	et	NNP
cord-254492-42d77vxf	124	4	al	al	NNP
cord-254492-42d77vxf	124	5	.	.	NNP
cord-254492-42d77vxf	124	6	,	,	,
cord-254492-42d77vxf	124	7	2011	2011	CD
cord-254492-42d77vxf	124	8	)	)	-RRB-
cord-254492-42d77vxf	124	9	.	.	.
cord-254492-42d77vxf	125	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	125	2	,	,	,
cord-254492-42d77vxf	125	3	TBK1	TBK1	NNP
cord-254492-42d77vxf	125	4	and	and	CC
cord-254492-42d77vxf	125	5	other	other	JJ
cord-254492-42d77vxf	125	6	key	key	JJ
cord-254492-42d77vxf	125	7	RLR	RLR	NNP
cord-254492-42d77vxf	125	8	cascade	cascade	NN
cord-254492-42d77vxf	125	9	proteins	protein	NNS
cord-254492-42d77vxf	125	10	interact	interact	VBP
cord-254492-42d77vxf	125	11	with	with	IN
cord-254492-42d77vxf	125	12	these	these	DT
cord-254492-42d77vxf	125	13	proteins	protein	NNS
cord-254492-42d77vxf	125	14	but	but	CC
cord-254492-42d77vxf	125	15	are	be	VBP
cord-254492-42d77vxf	125	16	activated	activate	VBN
cord-254492-42d77vxf	125	17	only	only	RB
cord-254492-42d77vxf	125	18	upon	upon	IN
cord-254492-42d77vxf	125	19	oligomerization	oligomerization	NN
cord-254492-42d77vxf	125	20	.	.	.
cord-254492-42d77vxf	126	1	Thus	thus	RB
cord-254492-42d77vxf	126	2	,	,	,
cord-254492-42d77vxf	126	3	steady	steady	JJ
cord-254492-42d77vxf	126	4	state	state	NN
cord-254492-42d77vxf	126	5	isolation	isolation	NN
cord-254492-42d77vxf	126	6	of	of	IN
cord-254492-42d77vxf	126	7	MAVS	MAVS	NNPS
cord-254492-42d77vxf	126	8	may	may	MD
cord-254492-42d77vxf	126	9	represent	represent	VB
cord-254492-42d77vxf	126	10	a	a	DT
cord-254492-42d77vxf	126	11	spatiotemporal	spatiotemporal	JJ
cord-254492-42d77vxf	126	12	barrier	barrier	NN
cord-254492-42d77vxf	126	13	that	that	WDT
cord-254492-42d77vxf	126	14	restrains	restrain	VBZ
cord-254492-42d77vxf	126	15	innate	innate	JJ
cord-254492-42d77vxf	126	16	immune	immune	JJ
cord-254492-42d77vxf	126	17	signaling	signaling	NN
cord-254492-42d77vxf	126	18	,	,	,
cord-254492-42d77vxf	126	19	overcome	overcome	VBN
cord-254492-42d77vxf	126	20	through	through	IN
cord-254492-42d77vxf	126	21	coordinating	coordinate	VBG
cord-254492-42d77vxf	126	22	these	these	DT
cord-254492-42d77vxf	126	23	proteins	protein	NNS
cord-254492-42d77vxf	126	24	into	into	IN
cord-254492-42d77vxf	126	25	signaling	signal	VBG
cord-254492-42d77vxf	126	26	complexes	complex	NNS
cord-254492-42d77vxf	126	27	upon	upon	IN
cord-254492-42d77vxf	126	28	MAVS	MAVS	NNP
cord-254492-42d77vxf	126	29	multimerization	multimerization	NNP
cord-254492-42d77vxf	126	30	.	.	.
cord-254492-42d77vxf	127	1	In	in	IN
cord-254492-42d77vxf	127	2	this	this	DT
cord-254492-42d77vxf	127	3	way	way	NN
cord-254492-42d77vxf	127	4	,	,	,
cord-254492-42d77vxf	127	5	it	-PRON-	PRP
cord-254492-42d77vxf	127	6	is	be	VBZ
cord-254492-42d77vxf	127	7	conceivable	conceivable	JJ
cord-254492-42d77vxf	127	8	how	how	WRB
cord-254492-42d77vxf	127	9	immunomodulating	immunomodulating	JJ
cord-254492-42d77vxf	127	10	E3s	e3s	NN
cord-254492-42d77vxf	127	11	/	/	,
cord-254492-42d77vxf	127	12	DUbs	DUbs	NNP
cord-254492-42d77vxf	127	13	may	may	MD
cord-254492-42d77vxf	127	14	be	be	VB
cord-254492-42d77vxf	127	15	compartmentalized	compartmentalize	VBN
cord-254492-42d77vxf	127	16	together	together	RB
cord-254492-42d77vxf	127	17	with	with	IN
cord-254492-42d77vxf	127	18	their	-PRON-	PRP$
cord-254492-42d77vxf	127	19	substrates	substrate	NNS
cord-254492-42d77vxf	127	20	.	.	.
cord-254492-42d77vxf	128	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	128	2	stringently	stringently	RB
cord-254492-42d77vxf	128	3	regulates	regulate	VBZ
cord-254492-42d77vxf	128	4	the	the	DT
cord-254492-42d77vxf	128	5	MAVS	MAVS	NNPS
cord-254492-42d77vxf	128	6	signalosome	signalosome	NNP
cord-254492-42d77vxf	128	7	.	.	.
cord-254492-42d77vxf	129	1	The	the	DT
cord-254492-42d77vxf	129	2	central	central	JJ
cord-254492-42d77vxf	129	3	position	position	NN
cord-254492-42d77vxf	129	4	that	that	WDT
cord-254492-42d77vxf	129	5	MAVS	MAVS	NNP
cord-254492-42d77vxf	129	6	occupies	occupy	VBZ
cord-254492-42d77vxf	129	7	within	within	IN
cord-254492-42d77vxf	129	8	the	the	DT
cord-254492-42d77vxf	129	9	RLR	RLR	NNP
cord-254492-42d77vxf	129	10	cascade	cascade	NN
cord-254492-42d77vxf	129	11	is	be	VBZ
cord-254492-42d77vxf	129	12	commensurate	commensurate	JJ
cord-254492-42d77vxf	129	13	with	with	IN
cord-254492-42d77vxf	129	14	the	the	DT
cord-254492-42d77vxf	129	15	many	many	JJ
cord-254492-42d77vxf	129	16	PTMs	ptm	NNS
cord-254492-42d77vxf	129	17	that	that	WDT
cord-254492-42d77vxf	129	18	modulate	modulate	VBP
cord-254492-42d77vxf	129	19	its	-PRON-	PRP$
cord-254492-42d77vxf	129	20	role	role	NN
cord-254492-42d77vxf	129	21	.	.	.
cord-254492-42d77vxf	130	1	To	to	IN
cord-254492-42d77vxf	130	2	our	-PRON-	PRP$
cord-254492-42d77vxf	130	3	knowledge	knowledge	NN
cord-254492-42d77vxf	130	4	,	,	,
cord-254492-42d77vxf	130	5	MAVS	MAVS	NNP
cord-254492-42d77vxf	130	6	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	130	7	has	have	VBZ
cord-254492-42d77vxf	130	8	not	not	RB
cord-254492-42d77vxf	130	9	been	be	VBN
cord-254492-42d77vxf	130	10	observed	observe	VBN
cord-254492-42d77vxf	130	11	in	in	IN
cord-254492-42d77vxf	130	12	resting	rest	VBG
cord-254492-42d77vxf	130	13	cells	cell	NNS
cord-254492-42d77vxf	130	14	using	use	VBG
cord-254492-42d77vxf	130	15	a	a	DT
cord-254492-42d77vxf	130	16	variety	variety	NN
cord-254492-42d77vxf	130	17	of	of	IN
cord-254492-42d77vxf	130	18	proteomic	proteomic	JJ
cord-254492-42d77vxf	130	19	and	and	CC
cord-254492-42d77vxf	130	20	biochemical	biochemical	JJ
cord-254492-42d77vxf	130	21	approaches	approach	NNS
cord-254492-42d77vxf	130	22	,	,	,
cord-254492-42d77vxf	130	23	indicating	indicate	VBG
cord-254492-42d77vxf	130	24	that	that	IN
cord-254492-42d77vxf	130	25	MAVS	mavs	RB
cord-254492-42d77vxf	130	26	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	130	27	occurs	occur	VBZ
cord-254492-42d77vxf	130	28	specifically	specifically	RB
cord-254492-42d77vxf	130	29	during	during	IN
cord-254492-42d77vxf	130	30	viral	viral	JJ
cord-254492-42d77vxf	130	31	infection	infection	NN
cord-254492-42d77vxf	130	32	.	.	.
cord-254492-42d77vxf	131	1	At	at	RB
cord-254492-42d77vxf	131	2	least	least	JJS
cord-254492-42d77vxf	131	3	seven	seven	CD
cord-254492-42d77vxf	131	4	E3s	e3s	NN
cord-254492-42d77vxf	131	5	ubiquitinate	ubiquitinate	JJ
cord-254492-42d77vxf	131	6	MAVS	MAVS	NNPS
cord-254492-42d77vxf	131	7	,	,	,
cord-254492-42d77vxf	131	8	leading	lead	VBG
cord-254492-42d77vxf	131	9	to	to	IN
cord-254492-42d77vxf	131	10	MAVS	MAVS	NNP
cord-254492-42d77vxf	131	11	degradation	degradation	NN
cord-254492-42d77vxf	131	12	in	in	IN
cord-254492-42d77vxf	131	13	almost	almost	RB
cord-254492-42d77vxf	131	14	every	every	DT
cord-254492-42d77vxf	131	15	case	case	NN
cord-254492-42d77vxf	131	16	,	,	,
cord-254492-42d77vxf	131	17	as	as	IN
cord-254492-42d77vxf	131	18	described	describe	VBN
cord-254492-42d77vxf	131	19	later	later	RB
cord-254492-42d77vxf	131	20	in	in	IN
cord-254492-42d77vxf	131	21	this	this	DT
cord-254492-42d77vxf	131	22	section	section	NN
cord-254492-42d77vxf	131	23	(	(	-LRB-
cord-254492-42d77vxf	131	24	Fig	Fig	NNP
cord-254492-42d77vxf	131	25	.	.	.
cord-254492-42d77vxf	131	26	3	3	CD
cord-254492-42d77vxf	131	27	)	)	-RRB-
cord-254492-42d77vxf	131	28	.	.	.
cord-254492-42d77vxf	132	1	At	at	RB
cord-254492-42d77vxf	132	2	least	least	RBS
cord-254492-42d77vxf	132	3	five	five	CD
cord-254492-42d77vxf	132	4	of	of	IN
cord-254492-42d77vxf	132	5	these	these	DT
cord-254492-42d77vxf	132	6	modify	modify	VBP
cord-254492-42d77vxf	132	7	other	other	JJ
cord-254492-42d77vxf	132	8	substrates	substrate	NNS
cord-254492-42d77vxf	132	9	within	within	IN
cord-254492-42d77vxf	132	10	the	the	DT
cord-254492-42d77vxf	132	11	same	same	JJ
cord-254492-42d77vxf	132	12	cascade	cascade	NN
cord-254492-42d77vxf	132	13	,	,	,
cord-254492-42d77vxf	132	14	highlighting	highlight	VBG
cord-254492-42d77vxf	132	15	MAVS	MAVS	NNPS
cord-254492-42d77vxf	132	16	as	as	IN
cord-254492-42d77vxf	132	17	a	a	DT
cord-254492-42d77vxf	132	18	crucial	crucial	JJ
cord-254492-42d77vxf	132	19	locus	locus	NN
cord-254492-42d77vxf	132	20	of	of	IN
cord-254492-42d77vxf	132	21	RLR	RLR	NNP
cord-254492-42d77vxf	132	22	regulation	regulation	NN
cord-254492-42d77vxf	132	23	.	.	.
cord-254492-42d77vxf	133	1	Accordingly	accordingly	RB
cord-254492-42d77vxf	133	2	,	,	,
cord-254492-42d77vxf	133	3	MAVS	MAVS	NNP
cord-254492-42d77vxf	133	4	is	be	VBZ
cord-254492-42d77vxf	133	5	targeted	target	VBN
cord-254492-42d77vxf	133	6	by	by	IN
cord-254492-42d77vxf	133	7	numerous	numerous	JJ
cord-254492-42d77vxf	133	8	viruses	virus	NNS
cord-254492-42d77vxf	133	9	in	in	IN
cord-254492-42d77vxf	133	10	a	a	DT
cord-254492-42d77vxf	133	11	variety	variety	NN
cord-254492-42d77vxf	133	12	of	of	IN
cord-254492-42d77vxf	133	13	ways	way	NNS
cord-254492-42d77vxf	133	14	;	;	:
cord-254492-42d77vxf	133	15	however	however	RB
cord-254492-42d77vxf	133	16	,	,	,
cord-254492-42d77vxf	133	17	with	with	IN
cord-254492-42d77vxf	133	18	the	the	DT
cord-254492-42d77vxf	133	19	exception	exception	NN
cord-254492-42d77vxf	133	20	of	of	IN
cord-254492-42d77vxf	133	21	HBV	HBV	NNP
cord-254492-42d77vxf	133	22	and	and	CC
cord-254492-42d77vxf	133	23	severe	severe	JJ
cord-254492-42d77vxf	133	24	acute	acute	JJ
cord-254492-42d77vxf	133	25	respiratory	respiratory	JJ
cord-254492-42d77vxf	133	26	syndrome	syndrome	NN
cord-254492-42d77vxf	133	27	-	-	HYPH
cord-254492-42d77vxf	133	28	coronavirus	coronavirus	NN
cord-254492-42d77vxf	133	29	(	(	-LRB-
cord-254492-42d77vxf	133	30	SARS	SARS	NNP
cord-254492-42d77vxf	133	31	-	-	HYPH
cord-254492-42d77vxf	133	32	CoV	CoV	NNP
cord-254492-42d77vxf	133	33	;	;	:
cord-254492-42d77vxf	134	1	Fig	Fig	NNP
cord-254492-42d77vxf	134	2	.	.	.
cord-254492-42d77vxf	135	1	3	3	LS
cord-254492-42d77vxf	135	2	;	;	:
cord-254492-42d77vxf	135	3	Wei	Wei	NNP
cord-254492-42d77vxf	135	4	et	et	NNP
cord-254492-42d77vxf	135	5	al	al	NNP
cord-254492-42d77vxf	135	6	.	.	NNP
cord-254492-42d77vxf	135	7	,	,	,
cord-254492-42d77vxf	135	8	2010	2010	CD
cord-254492-42d77vxf	136	1	;	;	:
cord-254492-42d77vxf	136	2	Shi	Shi	NNP
cord-254492-42d77vxf	136	3	et	et	FW
cord-254492-42d77vxf	136	4	al	al	NNP
cord-254492-42d77vxf	136	5	.	.	NNP
cord-254492-42d77vxf	136	6	,	,	,
cord-254492-42d77vxf	136	7	2014	2014	CD
cord-254492-42d77vxf	136	8	)	)	-RRB-
cord-254492-42d77vxf	136	9	,	,	,
cord-254492-42d77vxf	136	10	this	this	DT
cord-254492-42d77vxf	136	11	is	be	VBZ
cord-254492-42d77vxf	136	12	usually	usually	RB
cord-254492-42d77vxf	136	13	achieved	achieve	VBN
cord-254492-42d77vxf	136	14	by	by	IN
cord-254492-42d77vxf	136	15	means	mean	NNS
cord-254492-42d77vxf	136	16	other	other	JJ
cord-254492-42d77vxf	136	17	than	than	IN
cord-254492-42d77vxf	136	18	manipulating	manipulate	VBG
cord-254492-42d77vxf	136	19	MAVS	MAVS	NNP
cord-254492-42d77vxf	136	20	ubiquitination	ubiquitination	IN
cord-254492-42d77vxf	136	21	,	,	,
cord-254492-42d77vxf	136	22	likely	likely	RB
cord-254492-42d77vxf	136	23	given	give	VBN
cord-254492-42d77vxf	136	24	the	the	DT
cord-254492-42d77vxf	136	25	extensive	extensive	JJ
cord-254492-42d77vxf	136	26	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	136	27	-	-	HYPH
cord-254492-42d77vxf	136	28	mediated	mediate	VBN
cord-254492-42d77vxf	136	29	negative	negative	JJ
cord-254492-42d77vxf	136	30	regulatory	regulatory	JJ
cord-254492-42d77vxf	136	31	systems	system	NNS
cord-254492-42d77vxf	136	32	already	already	RB
cord-254492-42d77vxf	136	33	in	in	IN
cord-254492-42d77vxf	136	34	place	place	NN
cord-254492-42d77vxf	136	35	.	.	.
cord-254492-42d77vxf	137	1	MAVS	MAVS	NNP
cord-254492-42d77vxf	137	2	aggregation	aggregation	NN
cord-254492-42d77vxf	137	3	is	be	VBZ
cord-254492-42d77vxf	137	4	a	a	DT
cord-254492-42d77vxf	137	5	key	key	JJ
cord-254492-42d77vxf	137	6	feature	feature	NN
cord-254492-42d77vxf	137	7	of	of	IN
cord-254492-42d77vxf	137	8	RLR	RLR	NNP
cord-254492-42d77vxf	137	9	cascade	cascade	NN
cord-254492-42d77vxf	137	10	activation	activation	NN
cord-254492-42d77vxf	137	11	,	,	,
cord-254492-42d77vxf	137	12	but	but	CC
cord-254492-42d77vxf	137	13	how	how	WRB
cord-254492-42d77vxf	137	14	these	these	DT
cord-254492-42d77vxf	137	15	aggregates	aggregate	NNS
cord-254492-42d77vxf	137	16	are	be	VBP
cord-254492-42d77vxf	137	17	resolved	resolve	VBN
cord-254492-42d77vxf	137	18	during	during	IN
cord-254492-42d77vxf	137	19	deactivation	deactivation	NN
cord-254492-42d77vxf	137	20	is	be	VBZ
cord-254492-42d77vxf	137	21	only	only	RB
cord-254492-42d77vxf	137	22	beginning	begin	VBG
cord-254492-42d77vxf	137	23	to	to	TO
cord-254492-42d77vxf	137	24	be	be	VB
cord-254492-42d77vxf	137	25	clarified	clarify	VBN
cord-254492-42d77vxf	137	26	.	.	.
cord-254492-42d77vxf	138	1	In	in	IN
cord-254492-42d77vxf	138	2	addition	addition	NN
cord-254492-42d77vxf	138	3	to	to	IN
cord-254492-42d77vxf	138	4	ubiquitinating	ubiquitinating	NNP
cord-254492-42d77vxf	138	5	RIG	RIG	NNP
cord-254492-42d77vxf	138	6	-	-	:
cord-254492-42d77vxf	138	7	I	I	NNP
cord-254492-42d77vxf	138	8	and	and	CC
cord-254492-42d77vxf	138	9	enhancing	enhance	VBG
cord-254492-42d77vxf	138	10	its	-PRON-	PRP$
cord-254492-42d77vxf	138	11	association	association	NN
cord-254492-42d77vxf	138	12	with	with	IN
cord-254492-42d77vxf	138	13	MAVS	MAVS	NNP
cord-254492-42d77vxf	138	14	,	,	,
cord-254492-42d77vxf	138	15	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	138	16	ubiquitinates	ubiquitinate	NNS
cord-254492-42d77vxf	138	17	MAVS	mavs	RB
cord-254492-42d77vxf	138	18	at	at	IN
cord-254492-42d77vxf	138	19	Lys7	Lys7	NNP
cord-254492-42d77vxf	138	20	and	and	CC
cord-254492-42d77vxf	138	21	Lys10	Lys10	NNP
cord-254492-42d77vxf	138	22	and	and	CC
cord-254492-42d77vxf	138	23	induces	induce	VBZ
cord-254492-42d77vxf	138	24	its	-PRON-	PRP$
cord-254492-42d77vxf	138	25	partial	partial	JJ
cord-254492-42d77vxf	138	26	proteolysis	proteolysis	NN
cord-254492-42d77vxf	138	27	(	(	-LRB-
cord-254492-42d77vxf	138	28	Castanier	Castanier	NNP
cord-254492-42d77vxf	138	29	et	et	FW
cord-254492-42d77vxf	138	30	al	al	NNP
cord-254492-42d77vxf	138	31	.	.	NNP
cord-254492-42d77vxf	138	32	,	,	,
cord-254492-42d77vxf	138	33	2012	2012	CD
cord-254492-42d77vxf	138	34	)	)	-RRB-
cord-254492-42d77vxf	138	35	.	.	.
cord-254492-42d77vxf	139	1	This	this	DT
cord-254492-42d77vxf	139	2	was	be	VBD
cord-254492-42d77vxf	139	3	proposed	propose	VBN
cord-254492-42d77vxf	139	4	as	as	IN
cord-254492-42d77vxf	139	5	a	a	DT
cord-254492-42d77vxf	139	6	means	means	NN
cord-254492-42d77vxf	139	7	of	of	IN
cord-254492-42d77vxf	139	8	discharging	discharge	VBG
cord-254492-42d77vxf	139	9	the	the	DT
cord-254492-42d77vxf	139	10	activated	activate	VBN
cord-254492-42d77vxf	139	11	RLR	RLR	NNP
cord-254492-42d77vxf	139	12	signalosome	signalosome	NN
cord-254492-42d77vxf	139	13	from	from	IN
cord-254492-42d77vxf	139	14	the	the	DT
cord-254492-42d77vxf	139	15	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	139	16	recruitment	recruitment	NN
cord-254492-42d77vxf	139	17	platform	platform	NN
cord-254492-42d77vxf	139	18	and	and	CC
cord-254492-42d77vxf	139	19	would	would	MD
cord-254492-42d77vxf	139	20	begin	begin	VB
cord-254492-42d77vxf	139	21	to	to	TO
cord-254492-42d77vxf	139	22	address	address	VB
cord-254492-42d77vxf	139	23	how	how	WRB
cord-254492-42d77vxf	139	24	IRF3	IRF3	NNP
cord-254492-42d77vxf	139	25	and	and	CC
cord-254492-42d77vxf	139	26	other	other	JJ
cord-254492-42d77vxf	139	27	RLR	RLR	NNP
cord-254492-42d77vxf	139	28	signalosome	signalosome	NN
cord-254492-42d77vxf	139	29	components	component	NNS
cord-254492-42d77vxf	139	30	traffic	traffic	NN
cord-254492-42d77vxf	139	31	correctly	correctly	RB
cord-254492-42d77vxf	139	32	after	after	IN
cord-254492-42d77vxf	139	33	activation	activation	NN
cord-254492-42d77vxf	139	34	.	.	.
cord-254492-42d77vxf	140	1	More	more	RBR
cord-254492-42d77vxf	140	2	recently	recently	RB
cord-254492-42d77vxf	140	3	,	,	,
cord-254492-42d77vxf	140	4	Lys7	Lys7	NNP
cord-254492-42d77vxf	140	5	and	and	CC
cord-254492-42d77vxf	140	6	Lys500	lys500	CD
cord-254492-42d77vxf	140	7	were	be	VBD
cord-254492-42d77vxf	140	8	shown	show	VBN
cord-254492-42d77vxf	140	9	to	to	TO
cord-254492-42d77vxf	140	10	be	be	VB
cord-254492-42d77vxf	140	11	polyubiquitinated	polyubiquitinate	VBN
cord-254492-42d77vxf	140	12	by	by	IN
cord-254492-42d77vxf	140	13	membrane	membrane	NN
cord-254492-42d77vxf	140	14	-	-	HYPH
cord-254492-42d77vxf	140	15	associated	associate	VBN
cord-254492-42d77vxf	140	16	RING	ring	NN
cord-254492-42d77vxf	140	17	finger	finger	NN
cord-254492-42d77vxf	140	18	protein	protein	NN
cord-254492-42d77vxf	140	19	5	5	CD
cord-254492-42d77vxf	140	20	(	(	-LRB-
cord-254492-42d77vxf	140	21	MAR	MAR	NNP
cord-254492-42d77vxf	140	22	CH5	CH5	NNP
cord-254492-42d77vxf	140	23	)	)	-RRB-
cord-254492-42d77vxf	140	24	,	,	,
cord-254492-42d77vxf	140	25	a	a	DT
cord-254492-42d77vxf	140	26	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	140	27	membrane	membrane	NN
cord-254492-42d77vxf	140	28	-	-	HYPH
cord-254492-42d77vxf	140	29	bound	bind	VBN
cord-254492-42d77vxf	140	30	E3	E3	NNP
cord-254492-42d77vxf	140	31	that	that	WDT
cord-254492-42d77vxf	140	32	effectively	effectively	RB
cord-254492-42d77vxf	140	33	dissolves	dissolve	VBZ
cord-254492-42d77vxf	140	34	MAVS	MAVS	NNP
cord-254492-42d77vxf	140	35	aggregates	aggregate	NNS
cord-254492-42d77vxf	140	36	by	by	IN
cord-254492-42d77vxf	140	37	specifically	specifically	RB
cord-254492-42d77vxf	140	38	targeting	target	VBG
cord-254492-42d77vxf	140	39	them	-PRON-	PRP
cord-254492-42d77vxf	140	40	for	for	IN
cord-254492-42d77vxf	140	41	degradation	degradation	NN
cord-254492-42d77vxf	140	42	.	.	.
cord-254492-42d77vxf	141	1	MAR	MAR	NNP
cord-254492-42d77vxf	141	2	CH5	CH5	NNP
cord-254492-42d77vxf	141	3	is	be	VBZ
cord-254492-42d77vxf	141	4	an	an	DT
cord-254492-42d77vxf	141	5	important	important	JJ
cord-254492-42d77vxf	141	6	regulator	regulator	NN
cord-254492-42d77vxf	141	7	of	of	IN
cord-254492-42d77vxf	141	8	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	141	9	fission	fission	NN
cord-254492-42d77vxf	141	10	and	and	CC
cord-254492-42d77vxf	141	11	fusion	fusion	NN
cord-254492-42d77vxf	141	12	whose	whose	WP$
cord-254492-42d77vxf	141	13	expression	expression	NN
cord-254492-42d77vxf	141	14	is	be	VBZ
cord-254492-42d77vxf	141	15	up	up	RB
cord-254492-42d77vxf	141	16	-	-	HYPH
cord-254492-42d77vxf	141	17	regulated	regulate	VBN
cord-254492-42d77vxf	141	18	during	during	IN
cord-254492-42d77vxf	141	19	infection	infection	NN
cord-254492-42d77vxf	141	20	(	(	-LRB-
cord-254492-42d77vxf	141	21	Yoo	Yoo	NNP
cord-254492-42d77vxf	141	22	et	et	NNP
cord-254492-42d77vxf	141	23	al	al	NNP
cord-254492-42d77vxf	141	24	.	.	NNP
cord-254492-42d77vxf	141	25	,	,	,
cord-254492-42d77vxf	141	26	2015	2015	CD
cord-254492-42d77vxf	141	27	)	)	-RRB-
cord-254492-42d77vxf	141	28	.	.	.
cord-254492-42d77vxf	142	1	These	these	DT
cord-254492-42d77vxf	142	2	mechanisms	mechanism	NNS
cord-254492-42d77vxf	142	3	of	of	IN
cord-254492-42d77vxf	142	4	MAVS	MAVS	NNP
cord-254492-42d77vxf	142	5	aggregate	aggregate	JJ
cord-254492-42d77vxf	142	6	resolution	resolution	NN
cord-254492-42d77vxf	142	7	may	may	MD
cord-254492-42d77vxf	142	8	be	be	VB
cord-254492-42d77vxf	142	9	nonredundant	nonredundant	JJ
cord-254492-42d77vxf	142	10	,	,	,
cord-254492-42d77vxf	142	11	with	with	IN
cord-254492-42d77vxf	142	12	the	the	DT
cord-254492-42d77vxf	142	13	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	142	14	mechanism	mechanism	NN
cord-254492-42d77vxf	142	15	occurring	occur	VBG
cord-254492-42d77vxf	142	16	throughout	throughout	IN
cord-254492-42d77vxf	142	17	the	the	DT
cord-254492-42d77vxf	142	18	immune	immune	JJ
cord-254492-42d77vxf	142	19	response	response	NN
cord-254492-42d77vxf	142	20	and	and	CC
cord-254492-42d77vxf	142	21	the	the	DT
cord-254492-42d77vxf	142	22	MAR	MAR	NNP
cord-254492-42d77vxf	142	23	CH5	CH5	NNP
cord-254492-42d77vxf	142	24	mechanism	mechanism	NN
cord-254492-42d77vxf	142	25	amplifying	amplify	VBG
cord-254492-42d77vxf	142	26	gradually	gradually	RB
cord-254492-42d77vxf	142	27	in	in	IN
cord-254492-42d77vxf	142	28	an	an	DT
cord-254492-42d77vxf	142	29	IFN	IFN	NNP
cord-254492-42d77vxf	142	30	-	-	HYPH
cord-254492-42d77vxf	142	31	I	-PRON-	PRP
cord-254492-42d77vxf	142	32	negative	negative	JJ
cord-254492-42d77vxf	142	33	feedback	feedback	NN
cord-254492-42d77vxf	142	34	loop	loop	NN
cord-254492-42d77vxf	142	35	.	.	.
cord-254492-42d77vxf	143	1	Complete	complete	JJ
cord-254492-42d77vxf	143	2	MAVS	MAVS	NNP
cord-254492-42d77vxf	143	3	degradation	degradation	NN
cord-254492-42d77vxf	143	4	is	be	VBZ
cord-254492-42d77vxf	143	5	independently	independently	RB
cord-254492-42d77vxf	143	6	promoted	promote	VBN
cord-254492-42d77vxf	143	7	by	by	IN
cord-254492-42d77vxf	143	8	the	the	DT
cord-254492-42d77vxf	143	9	E3s	E3s	NNP
cord-254492-42d77vxf	143	10	RNF5	RNF5	NNP
cord-254492-42d77vxf	143	11	,	,	,
cord-254492-42d77vxf	143	12	RNF125	RNF125	NNP
cord-254492-42d77vxf	143	13	,	,	,
cord-254492-42d77vxf	143	14	atrophin-1-interacting	atrophin-1-interacte	VBG
cord-254492-42d77vxf	143	15	protein	protein	NN
cord-254492-42d77vxf	143	16	4	4	CD
cord-254492-42d77vxf	143	17	(	(	-LRB-
cord-254492-42d77vxf	143	18	AIP4	AIP4	NNP
cord-254492-42d77vxf	143	19	;	;	:
cord-254492-42d77vxf	143	20	also	also	RB
cord-254492-42d77vxf	143	21	termed	term	VBN
cord-254492-42d77vxf	143	22	ITCH	itch	NN
cord-254492-42d77vxf	143	23	)	)	-RRB-
cord-254492-42d77vxf	143	24	,	,	,
cord-254492-42d77vxf	143	25	SMAD	SMAD	NNP
cord-254492-42d77vxf	143	26	ubiquitination	ubiquitination	VBD
cord-254492-42d77vxf	143	27	regulatory	regulatory	JJ
cord-254492-42d77vxf	143	28	factor	factor	NN
cord-254492-42d77vxf	143	29	1	1	CD
cord-254492-42d77vxf	143	30	(	(	-LRB-
cord-254492-42d77vxf	143	31	Smurf1	Smurf1	NNP
cord-254492-42d77vxf	143	32	)	)	-RRB-
cord-254492-42d77vxf	143	33	,	,	,
cord-254492-42d77vxf	143	34	and	and	CC
cord-254492-42d77vxf	143	35	Smurf2	Smurf2	NNP
cord-254492-42d77vxf	144	1	(	(	-LRB-
cord-254492-42d77vxf	144	2	Fig	Fig	NNP
cord-254492-42d77vxf	144	3	.	.	.
cord-254492-42d77vxf	144	4	3	3	CD
cord-254492-42d77vxf	144	5	)	)	-RRB-
cord-254492-42d77vxf	144	6	.	.	.
cord-254492-42d77vxf	145	1	RNF5	RNF5	NNP
cord-254492-42d77vxf	145	2	polyubiquitinates	polyubiquitinate	NNS
cord-254492-42d77vxf	145	3	MAVS	mavs	RB
cord-254492-42d77vxf	145	4	at	at	IN
cord-254492-42d77vxf	145	5	Lys362	lys362	ADD
cord-254492-42d77vxf	146	1	and	and	CC
cord-254492-42d77vxf	146	2	Lys461	lys461	DT
cord-254492-42d77vxf	146	3	,	,	,
cord-254492-42d77vxf	146	4	whereas	whereas	IN
cord-254492-42d77vxf	146	5	the	the	DT
cord-254492-42d77vxf	146	6	adjacent	adjacent	JJ
cord-254492-42d77vxf	146	7	residues	residue	NNS
cord-254492-42d77vxf	146	8	Lys371	Lys371	NNP
cord-254492-42d77vxf	146	9	and	and	CC
cord-254492-42d77vxf	146	10	Lys420	Lys420	NNP
cord-254492-42d77vxf	146	11	are	be	VBP
cord-254492-42d77vxf	146	12	polyubiquitinated	polyubiquitinate	VBN
cord-254492-42d77vxf	146	13	by	by	IN
cord-254492-42d77vxf	146	14	AIP4	AIP4	NNP
cord-254492-42d77vxf	146	15	upon	upon	IN
cord-254492-42d77vxf	146	16	recruitment	recruitment	NN
cord-254492-42d77vxf	146	17	by	by	IN
cord-254492-42d77vxf	146	18	poly(rC)-binding	poly(rC)-binding	NNP
cord-254492-42d77vxf	146	19	protein	protein	NN
cord-254492-42d77vxf	146	20	1	1	CD
cord-254492-42d77vxf	146	21	(	(	-LRB-
cord-254492-42d77vxf	146	22	PCBP1	PCBP1	NNS
cord-254492-42d77vxf	146	23	)	)	-RRB-
cord-254492-42d77vxf	146	24	or	or	CC
cord-254492-42d77vxf	146	25	PCBP2	PCBP2	NNP
cord-254492-42d77vxf	147	1	(	(	-LRB-
cord-254492-42d77vxf	147	2	You	-PRON-	PRP
cord-254492-42d77vxf	147	3	et	et	FW
cord-254492-42d77vxf	147	4	al	al	NNP
cord-254492-42d77vxf	147	5	.	.	.
cord-254492-42d77vxf	148	1	,	,	,
cord-254492-42d77vxf	148	2	2009	2009	CD
cord-254492-42d77vxf	148	3	;	;	:
cord-254492-42d77vxf	148	4	Zhong	Zhong	NNP
cord-254492-42d77vxf	148	5	et	et	NNP
cord-254492-42d77vxf	148	6	al	al	NNP
cord-254492-42d77vxf	148	7	.	.	NNP
cord-254492-42d77vxf	148	8	,	,	,
cord-254492-42d77vxf	148	9	2010	2010	CD
cord-254492-42d77vxf	148	10	;	;	:
cord-254492-42d77vxf	148	11	Zhou	Zhou	NNP
cord-254492-42d77vxf	148	12	et	et	NNP
cord-254492-42d77vxf	148	13	al	al	NNP
cord-254492-42d77vxf	148	14	.	.	NNP
cord-254492-42d77vxf	148	15	,	,	,
cord-254492-42d77vxf	148	16	2012	2012	CD
cord-254492-42d77vxf	148	17	)	)	-RRB-
cord-254492-42d77vxf	148	18	.	.	.
cord-254492-42d77vxf	149	1	AIP4	AIP4	NNP
cord-254492-42d77vxf	149	2	additionally	additionally	RB
cord-254492-42d77vxf	149	3	inhibits	inhibit	VBZ
cord-254492-42d77vxf	149	4	IFN	IFN	NNP
cord-254492-42d77vxf	149	5	-	-	HYPH
cord-254492-42d77vxf	149	6	I	-PRON-	PRP
cord-254492-42d77vxf	149	7	as	as	RB
cord-254492-42d77vxf	149	8	well	well	RB
cord-254492-42d77vxf	149	9	as	as	IN
cord-254492-42d77vxf	149	10	NF	nf	NN
cord-254492-42d77vxf	149	11	-	-	HYPH
cord-254492-42d77vxf	149	12	κB	κb	CD
cord-254492-42d77vxf	149	13	activation	activation	NN
cord-254492-42d77vxf	149	14	by	by	IN
cord-254492-42d77vxf	149	15	ubiquitinating	ubiquitinate	VBG
cord-254492-42d77vxf	149	16	the	the	DT
cord-254492-42d77vxf	149	17	inhibitor	inhibitor	NN
cord-254492-42d77vxf	149	18	of	of	IN
cord-254492-42d77vxf	149	19	apoptosis	apoptosis	NN
cord-254492-42d77vxf	149	20	protein	protein	NN
cord-254492-42d77vxf	149	21	1	1	CD
cord-254492-42d77vxf	149	22	(	(	-LRB-
cord-254492-42d77vxf	149	23	cIAP1	ciap1	NN
cord-254492-42d77vxf	149	24	)	)	-RRB-
cord-254492-42d77vxf	149	25	,	,	,
cord-254492-42d77vxf	149	26	targeting	target	VBG
cord-254492-42d77vxf	149	27	it	-PRON-	PRP
cord-254492-42d77vxf	149	28	for	for	IN
cord-254492-42d77vxf	149	29	lysosomal	lysosomal	JJ
cord-254492-42d77vxf	149	30	degradation	degradation	NN
cord-254492-42d77vxf	149	31	(	(	-LRB-
cord-254492-42d77vxf	149	32	Tigno	Tigno	NNP
cord-254492-42d77vxf	149	33	-	-	HYPH
cord-254492-42d77vxf	149	34	Aranjuez	Aranjuez	NNP
cord-254492-42d77vxf	149	35	et	et	NNP
cord-254492-42d77vxf	149	36	al	al	NNP
cord-254492-42d77vxf	149	37	.	.	NNP
cord-254492-42d77vxf	149	38	,	,	,
cord-254492-42d77vxf	149	39	2013	2013	CD
cord-254492-42d77vxf	149	40	)	)	-RRB-
cord-254492-42d77vxf	149	41	.	.	.
cord-254492-42d77vxf	150	1	cIAP1	ciap1	NN
cord-254492-42d77vxf	150	2	is	be	VBZ
cord-254492-42d77vxf	150	3	an	an	DT
cord-254492-42d77vxf	150	4	E3	e3	NN
cord-254492-42d77vxf	150	5	that	that	WDT
cord-254492-42d77vxf	150	6	activates	activate	VBZ
cord-254492-42d77vxf	150	7	TRAF3/6	TRAF3/6	NNP
cord-254492-42d77vxf	150	8	during	during	IN
cord-254492-42d77vxf	150	9	viral	viral	JJ
cord-254492-42d77vxf	150	10	infection	infection	NN
cord-254492-42d77vxf	151	1	(	(	-LRB-
cord-254492-42d77vxf	151	2	Mao	Mao	NNP
cord-254492-42d77vxf	151	3	et	et	NNP
cord-254492-42d77vxf	151	4	al	al	NNP
cord-254492-42d77vxf	151	5	.	.	NNP
cord-254492-42d77vxf	151	6	,	,	,
cord-254492-42d77vxf	151	7	2010	2010	CD
cord-254492-42d77vxf	151	8	)	)	-RRB-
cord-254492-42d77vxf	151	9	,	,	,
cord-254492-42d77vxf	151	10	revealing	reveal	VBG
cord-254492-42d77vxf	151	11	that	that	IN
cord-254492-42d77vxf	151	12	AIP4	AIP4	NNP
cord-254492-42d77vxf	151	13	broadly	broadly	RB
cord-254492-42d77vxf	151	14	and	and	CC
cord-254492-42d77vxf	151	15	multiply	multiply	VB
cord-254492-42d77vxf	151	16	inhibits	inhibit	VBZ
cord-254492-42d77vxf	151	17	NLR-	NLR-	NNP
cord-254492-42d77vxf	151	18	,	,	,
cord-254492-42d77vxf	151	19	RLR-	RLR-	NNP
cord-254492-42d77vxf	151	20	,	,	,
cord-254492-42d77vxf	151	21	and	and	CC
cord-254492-42d77vxf	151	22	TLR	tlr	NN
cord-254492-42d77vxf	151	23	-	-	HYPH
cord-254492-42d77vxf	151	24	mediated	mediate	VBN
cord-254492-42d77vxf	151	25	immune	immune	NN
cord-254492-42d77vxf	151	26	signaling	signaling	NN
cord-254492-42d77vxf	151	27	.	.	.
cord-254492-42d77vxf	152	1	The	the	DT
cord-254492-42d77vxf	152	2	acceptor	acceptor	NN
cord-254492-42d77vxf	152	3	site	site	NN
cord-254492-42d77vxf	152	4	or	or	CC
cord-254492-42d77vxf	152	5	sites	site	NNS
cord-254492-42d77vxf	152	6	for	for	IN
cord-254492-42d77vxf	152	7	RNF125-induced	RNF125-induced	NNP
cord-254492-42d77vxf	152	8	MAVS	MAVS	NNPS
cord-254492-42d77vxf	152	9	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	152	10	are	be	VBP
cord-254492-42d77vxf	152	11	unknown	unknown	JJ
cord-254492-42d77vxf	152	12	;	;	:
cord-254492-42d77vxf	152	13	however	however	RB
cord-254492-42d77vxf	152	14	,	,	,
cord-254492-42d77vxf	152	15	given	give	VBN
cord-254492-42d77vxf	152	16	that	that	IN
cord-254492-42d77vxf	152	17	RNF125	RNF125	NNP
cord-254492-42d77vxf	152	18	also	also	RB
cord-254492-42d77vxf	152	19	ubiquitinates	ubiquitinate	VBZ
cord-254492-42d77vxf	152	20	the	the	DT
cord-254492-42d77vxf	152	21	activated	activate	VBN
cord-254492-42d77vxf	152	22	CARDs	card	NNS
cord-254492-42d77vxf	152	23	of	of	IN
cord-254492-42d77vxf	152	24	RIG	rig	NN
cord-254492-42d77vxf	152	25	-	-	:
cord-254492-42d77vxf	152	26	I	I	NNP
cord-254492-42d77vxf	152	27	and	and	CC
cord-254492-42d77vxf	152	28	MDA5	MDA5	NNP
cord-254492-42d77vxf	153	1	(	(	-LRB-
cord-254492-42d77vxf	153	2	Arimoto	Arimoto	NNP
cord-254492-42d77vxf	153	3	et	et	NNP
cord-254492-42d77vxf	153	4	al	al	NNP
cord-254492-42d77vxf	153	5	.	.	NNP
cord-254492-42d77vxf	153	6	,	,	,
cord-254492-42d77vxf	153	7	2007	2007	CD
cord-254492-42d77vxf	153	8	)	)	-RRB-
cord-254492-42d77vxf	153	9	,	,	,
cord-254492-42d77vxf	153	10	the	the	DT
cord-254492-42d77vxf	153	11	MAVS	MAVS	NNP
cord-254492-42d77vxf	153	12	CARD	CARD	NNP
cord-254492-42d77vxf	153	13	appears	appear	VBZ
cord-254492-42d77vxf	153	14	a	a	DT
cord-254492-42d77vxf	153	15	likely	likely	JJ
cord-254492-42d77vxf	153	16	candidate	candidate	NN
cord-254492-42d77vxf	153	17	.	.	.
cord-254492-42d77vxf	154	1	NEDD4	NEDD4	NNP
cord-254492-42d77vxf	154	2	family	family	NN
cord-254492-42d77vxf	154	3	-	-	HYPH
cord-254492-42d77vxf	154	4	interacting	interact	VBG
cord-254492-42d77vxf	154	5	protein	protein	NN
cord-254492-42d77vxf	154	6	1	1	CD
cord-254492-42d77vxf	155	1	(	(	-LRB-
cord-254492-42d77vxf	155	2	Ndfip1	Ndfip1	NNP
cord-254492-42d77vxf	155	3	)	)	-RRB-
cord-254492-42d77vxf	155	4	binds	bind	VBZ
cord-254492-42d77vxf	155	5	MAVS	MAVS	NNP
cord-254492-42d77vxf	155	6	and	and	CC
cord-254492-42d77vxf	155	7	recruits	recruit	VBZ
cord-254492-42d77vxf	155	8	Smurf1	Smurf1	NNP
cord-254492-42d77vxf	155	9	and	and	CC
cord-254492-42d77vxf	155	10	possibly	possibly	RB
cord-254492-42d77vxf	155	11	Smurf2	Smurf2	NNP
cord-254492-42d77vxf	155	12	,	,	,
cord-254492-42d77vxf	155	13	facilitating	facilitate	VBG
cord-254492-42d77vxf	155	14	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	155	15	of	of	IN
cord-254492-42d77vxf	155	16	unknown	unknown	JJ
cord-254492-42d77vxf	155	17	sites	site	NNS
cord-254492-42d77vxf	155	18	within	within	IN
cord-254492-42d77vxf	155	19	MAVS	MAVS	NNP
cord-254492-42d77vxf	156	1	(	(	-LRB-
cord-254492-42d77vxf	156	2	Wang	Wang	NNP
cord-254492-42d77vxf	156	3	et	et	NNP
cord-254492-42d77vxf	156	4	al	al	NNP
cord-254492-42d77vxf	156	5	.	.	NNP
cord-254492-42d77vxf	156	6	,	,	,
cord-254492-42d77vxf	156	7	2012c	2012c	CD
cord-254492-42d77vxf	156	8	;	;	:
cord-254492-42d77vxf	157	1	Pan	Pan	NNP
cord-254492-42d77vxf	157	2	et	et	NNP
cord-254492-42d77vxf	157	3	al	al	NNP
cord-254492-42d77vxf	157	4	.	.	NNP
cord-254492-42d77vxf	157	5	,	,	,
cord-254492-42d77vxf	157	6	2014	2014	CD
cord-254492-42d77vxf	157	7	)	)	-RRB-
cord-254492-42d77vxf	157	8	.	.	.
cord-254492-42d77vxf	158	1	Moreover	moreover	RB
cord-254492-42d77vxf	158	2	,	,	,
cord-254492-42d77vxf	158	3	numerous	numerous	JJ
cord-254492-42d77vxf	158	4	TRAFs	traf	NNS
cord-254492-42d77vxf	158	5	,	,	,
cord-254492-42d77vxf	158	6	including	include	VBG
cord-254492-42d77vxf	158	7	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	158	8	and	and	CC
cord-254492-42d77vxf	158	9	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	158	10	,	,	,
cord-254492-42d77vxf	158	11	interact	interact	VB
cord-254492-42d77vxf	158	12	with	with	IN
cord-254492-42d77vxf	158	13	MAVS	MAVS	NNPS
cord-254492-42d77vxf	158	14	,	,	,
cord-254492-42d77vxf	158	15	and	and	CC
cord-254492-42d77vxf	158	16	Smurf1	Smurf1	NNP
cord-254492-42d77vxf	158	17	also	also	RB
cord-254492-42d77vxf	158	18	targets	target	VBZ
cord-254492-42d77vxf	158	19	these	these	DT
cord-254492-42d77vxf	158	20	for	for	IN
cord-254492-42d77vxf	158	21	degradation	degradation	NN
cord-254492-42d77vxf	158	22	(	(	-LRB-
cord-254492-42d77vxf	158	23	Li	Li	NNP
cord-254492-42d77vxf	158	24	et	et	NNP
cord-254492-42d77vxf	158	25	al	al	NNP
cord-254492-42d77vxf	158	26	.	.	NNP
cord-254492-42d77vxf	158	27	,	,	,
cord-254492-42d77vxf	158	28	2010a	2010a	CD
cord-254492-42d77vxf	158	29	)	)	-RRB-
cord-254492-42d77vxf	158	30	.	.	.
cord-254492-42d77vxf	159	1	Finally	finally	RB
cord-254492-42d77vxf	159	2	,	,	,
cord-254492-42d77vxf	159	3	Lys500	Lys500	NNP
cord-254492-42d77vxf	159	4	was	be	VBD
cord-254492-42d77vxf	159	5	reported	report	VBN
cord-254492-42d77vxf	159	6	as	as	IN
cord-254492-42d77vxf	159	7	a	a	DT
cord-254492-42d77vxf	159	8	single	single	JJ
cord-254492-42d77vxf	159	9	site	site	NN
cord-254492-42d77vxf	159	10	of	of	IN
cord-254492-42d77vxf	159	11	IFN	IFN	NNP
cord-254492-42d77vxf	159	12	-	-	HYPH
cord-254492-42d77vxf	159	13	I	I	NNP
cord-254492-42d77vxf	159	14	-	-	HYPH
cord-254492-42d77vxf	159	15	activating	activate	VBG
cord-254492-42d77vxf	159	16	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	159	17	by	by	IN
cord-254492-42d77vxf	159	18	an	an	DT
cord-254492-42d77vxf	159	19	unknown	unknown	JJ
cord-254492-42d77vxf	159	20	E3	e3	NN
cord-254492-42d77vxf	159	21	,	,	,
cord-254492-42d77vxf	159	22	inhibiting	inhibit	VBG
cord-254492-42d77vxf	159	23	NF	nf	NN
cord-254492-42d77vxf	159	24	-	-	HYPH
cord-254492-42d77vxf	159	25	κB	κb	CD
cord-254492-42d77vxf	159	26	activation	activation	NN
cord-254492-42d77vxf	159	27	by	by	IN
cord-254492-42d77vxf	159	28	sequestering	sequester	VBG
cord-254492-42d77vxf	159	29	IKKε	IKKε	NNS
cord-254492-42d77vxf	159	30	(	(	-LRB-
cord-254492-42d77vxf	159	31	Paz	Paz	NNP
cord-254492-42d77vxf	159	32	et	et	NNP
cord-254492-42d77vxf	159	33	al	al	NNP
cord-254492-42d77vxf	159	34	.	.	NNP
cord-254492-42d77vxf	159	35	,	,	,
cord-254492-42d77vxf	159	36	2009	2009	CD
cord-254492-42d77vxf	159	37	)	)	-RRB-
cord-254492-42d77vxf	159	38	.	.	.
cord-254492-42d77vxf	160	1	The	the	DT
cord-254492-42d77vxf	160	2	TRAFs	traf	NNS
cord-254492-42d77vxf	160	3	are	be	VBP
cord-254492-42d77vxf	160	4	six	six	CD
cord-254492-42d77vxf	160	5	multifunctional	multifunctional	JJ
cord-254492-42d77vxf	160	6	adaptor	adaptor	NN
cord-254492-42d77vxf	160	7	proteins	protein	NNS
cord-254492-42d77vxf	160	8	that	that	WDT
cord-254492-42d77vxf	160	9	regulate	regulate	VBP
cord-254492-42d77vxf	160	10	both	both	DT
cord-254492-42d77vxf	160	11	NF	nf	NN
cord-254492-42d77vxf	160	12	-	-	HYPH
cord-254492-42d77vxf	160	13	κB	κb	CD
cord-254492-42d77vxf	160	14	activation	activation	NN
cord-254492-42d77vxf	160	15	and	and	CC
cord-254492-42d77vxf	160	16	IFN	IFN	NNP
cord-254492-42d77vxf	160	17	-	-	HYPH
cord-254492-42d77vxf	160	18	I	-PRON-	PRP
cord-254492-42d77vxf	160	19	expression	expression	NN
cord-254492-42d77vxf	160	20	via	via	IN
cord-254492-42d77vxf	160	21	the	the	DT
cord-254492-42d77vxf	160	22	RLR	RLR	NNP
cord-254492-42d77vxf	160	23	,	,	,
cord-254492-42d77vxf	160	24	NLR	NLR	NNP
cord-254492-42d77vxf	160	25	,	,	,
cord-254492-42d77vxf	160	26	and	and	CC
cord-254492-42d77vxf	160	27	TLR	TLR	NNP
cord-254492-42d77vxf	160	28	protein	protein	NN
cord-254492-42d77vxf	160	29	signaling	signal	VBG
cord-254492-42d77vxf	160	30	cascades	cascade	NNS
cord-254492-42d77vxf	161	1	(	(	-LRB-
cord-254492-42d77vxf	161	2	Fig	Fig	NNP
cord-254492-42d77vxf	161	3	.	.	NNP
cord-254492-42d77vxf	161	4	2	2	CD
cord-254492-42d77vxf	161	5	)	)	-RRB-
cord-254492-42d77vxf	161	6	.	.	.
cord-254492-42d77vxf	162	1	TRAF	TRAF	NNP
cord-254492-42d77vxf	162	2	-	-	HYPH
cord-254492-42d77vxf	162	3	mediated	mediate	VBN
cord-254492-42d77vxf	162	4	signaling	signal	VBG
cord-254492-42d77vxf	162	5	outcomes	outcome	NNS
cord-254492-42d77vxf	162	6	are	be	VBP
cord-254492-42d77vxf	162	7	augmented	augment	VBN
cord-254492-42d77vxf	162	8	by	by	IN
cord-254492-42d77vxf	162	9	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	162	10	,	,	,
cord-254492-42d77vxf	162	11	and	and	CC
cord-254492-42d77vxf	162	12	,	,	,
cord-254492-42d77vxf	162	13	excepting	except	VBG
cord-254492-42d77vxf	162	14	TRAF1	traf1	JJ
cord-254492-42d77vxf	162	15	,	,	,
cord-254492-42d77vxf	162	16	all	all	DT
cord-254492-42d77vxf	162	17	TRAFs	traf	NNS
cord-254492-42d77vxf	162	18	possess	possess	VBP
cord-254492-42d77vxf	162	19	a	a	DT
cord-254492-42d77vxf	162	20	RING	ring	NN
cord-254492-42d77vxf	162	21	finger	finger	NN
cord-254492-42d77vxf	162	22	domain	domain	NN
cord-254492-42d77vxf	162	23	and	and	CC
cord-254492-42d77vxf	162	24	multiple	multiple	JJ
cord-254492-42d77vxf	162	25	zinc	zinc	NN
cord-254492-42d77vxf	162	26	coordination	coordination	NN
cord-254492-42d77vxf	162	27	sites	site	NNS
cord-254492-42d77vxf	162	28	,	,	,
cord-254492-42d77vxf	162	29	features	feature	VBZ
cord-254492-42d77vxf	162	30	typical	typical	JJ
cord-254492-42d77vxf	162	31	of	of	IN
cord-254492-42d77vxf	162	32	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	162	33	E3s	e3s	NN
cord-254492-42d77vxf	162	34	.	.	.
cord-254492-42d77vxf	163	1	K63-linked	k63-linked	JJ
cord-254492-42d77vxf	163	2	autoubiquitination	autoubiquitination	NN
cord-254492-42d77vxf	163	3	at	at	IN
cord-254492-42d77vxf	163	4	Lys124	Lys124	NNP
cord-254492-42d77vxf	163	5	is	be	VBZ
cord-254492-42d77vxf	163	6	a	a	DT
cord-254492-42d77vxf	163	7	key	key	JJ
cord-254492-42d77vxf	163	8	activation	activation	NN
cord-254492-42d77vxf	163	9	mechanism	mechanism	NN
cord-254492-42d77vxf	163	10	of	of	IN
cord-254492-42d77vxf	163	11	TRAF6	traf6	NN
cord-254492-42d77vxf	164	1	(	(	-LRB-
cord-254492-42d77vxf	164	2	Lamothe	Lamothe	NNP
cord-254492-42d77vxf	164	3	et	et	FW
cord-254492-42d77vxf	164	4	al	al	NNP
cord-254492-42d77vxf	164	5	.	.	NNP
cord-254492-42d77vxf	164	6	,	,	,
cord-254492-42d77vxf	164	7	2007	2007	CD
cord-254492-42d77vxf	165	1	;	;	:
cord-254492-42d77vxf	165	2	Jiao	Jiao	NNP
cord-254492-42d77vxf	165	3	et	et	NNP
cord-254492-42d77vxf	165	4	al	al	NNP
cord-254492-42d77vxf	165	5	.	.	NNP
cord-254492-42d77vxf	165	6	,	,	,
cord-254492-42d77vxf	165	7	2015	2015	CD
cord-254492-42d77vxf	165	8	)	)	-RRB-
cord-254492-42d77vxf	165	9	and	and	CC
cord-254492-42d77vxf	165	10	possibly	possibly	RB
cord-254492-42d77vxf	165	11	TRAF2	traf2	XX
cord-254492-42d77vxf	166	1	(	(	-LRB-
cord-254492-42d77vxf	166	2	Habelhah	Habelhah	NNP
cord-254492-42d77vxf	166	3	et	et	NNP
cord-254492-42d77vxf	166	4	al	al	NNP
cord-254492-42d77vxf	166	5	.	.	NNP
cord-254492-42d77vxf	166	6	,	,	,
cord-254492-42d77vxf	166	7	2004	2004	CD
cord-254492-42d77vxf	166	8	)	)	-RRB-
cord-254492-42d77vxf	166	9	,	,	.
cord-254492-42d77vxf	167	1	TRAF4	traf4	JJ
cord-254492-42d77vxf	168	1	(	(	-LRB-
cord-254492-42d77vxf	168	2	Marinis	Marinis	NNP
cord-254492-42d77vxf	168	3	et	et	NNP
cord-254492-42d77vxf	168	4	al	al	NNP
cord-254492-42d77vxf	168	5	.	.	NNP
cord-254492-42d77vxf	168	6	,	,	,
cord-254492-42d77vxf	168	7	2012	2012	CD
cord-254492-42d77vxf	168	8	)	)	-RRB-
cord-254492-42d77vxf	168	9	,	,	,
cord-254492-42d77vxf	168	10	and	and	CC
cord-254492-42d77vxf	168	11	TRAF5	traf5	NN
cord-254492-42d77vxf	169	1	(	(	-LRB-
cord-254492-42d77vxf	169	2	Zhong	Zhong	NNP
cord-254492-42d77vxf	169	3	et	et	NNP
cord-254492-42d77vxf	169	4	al	al	NNP
cord-254492-42d77vxf	169	5	.	.	NNP
cord-254492-42d77vxf	169	6	,	,	,
cord-254492-42d77vxf	169	7	2012	2012	CD
cord-254492-42d77vxf	169	8	)	)	-RRB-
cord-254492-42d77vxf	169	9	.	.	.
cord-254492-42d77vxf	170	1	In	in	IN
cord-254492-42d77vxf	170	2	vitro	vitro	FW
cord-254492-42d77vxf	170	3	TRAF3	traf3	NN
cord-254492-42d77vxf	170	4	ubiquitination	ubiquitination	IN
cord-254492-42d77vxf	170	5	assays	assay	NNS
cord-254492-42d77vxf	170	6	and	and	CC
cord-254492-42d77vxf	170	7	analysis	analysis	NN
cord-254492-42d77vxf	170	8	of	of	IN
cord-254492-42d77vxf	170	9	recombinant	recombinant	JJ
cord-254492-42d77vxf	170	10	TRAF3ΔRI	traf3δri	CD
cord-254492-42d77vxf	170	11	NG	NG	NNP
cord-254492-42d77vxf	170	12	isolated	isolate	VBN
cord-254492-42d77vxf	170	13	from	from	IN
cord-254492-42d77vxf	170	14	mammalian	mammalian	JJ
cord-254492-42d77vxf	170	15	cell	cell	NN
cord-254492-42d77vxf	170	16	lysates	lysate	NNS
cord-254492-42d77vxf	170	17	are	be	VBP
cord-254492-42d77vxf	170	18	also	also	RB
cord-254492-42d77vxf	170	19	consistent	consistent	JJ
cord-254492-42d77vxf	170	20	with	with	IN
cord-254492-42d77vxf	170	21	an	an	DT
cord-254492-42d77vxf	170	22	autoubiquitination	autoubiquitination	NN
cord-254492-42d77vxf	170	23	activation	activation	NN
cord-254492-42d77vxf	170	24	mechanism	mechanism	NN
cord-254492-42d77vxf	170	25	for	for	IN
cord-254492-42d77vxf	170	26	TRAF3	traf3	NN
cord-254492-42d77vxf	171	1	(	(	-LRB-
cord-254492-42d77vxf	171	2	Kayagaki	Kayagaki	NNP
cord-254492-42d77vxf	171	3	et	et	NNP
cord-254492-42d77vxf	171	4	al	al	NNP
cord-254492-42d77vxf	171	5	.	.	NNP
cord-254492-42d77vxf	171	6	,	,	,
cord-254492-42d77vxf	171	7	2007	2007	CD
cord-254492-42d77vxf	171	8	;	;	:
cord-254492-42d77vxf	171	9	Zeng	Zeng	NNP
cord-254492-42d77vxf	171	10	et	et	FW
cord-254492-42d77vxf	171	11	al	al	NNP
cord-254492-42d77vxf	171	12	.	.	NNP
cord-254492-42d77vxf	171	13	,	,	,
cord-254492-42d77vxf	171	14	2009	2009	CD
cord-254492-42d77vxf	171	15	)	)	-RRB-
cord-254492-42d77vxf	171	16	.	.	.
cord-254492-42d77vxf	172	1	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	173	1	and	and	CC
cord-254492-42d77vxf	173	2	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	173	3	are	be	VBP
cord-254492-42d77vxf	173	4	among	among	IN
cord-254492-42d77vxf	173	5	the	the	DT
cord-254492-42d77vxf	173	6	first	first	JJ
cord-254492-42d77vxf	173	7	molecules	molecule	NNS
cord-254492-42d77vxf	173	8	activated	activate	VBN
cord-254492-42d77vxf	173	9	by	by	IN
cord-254492-42d77vxf	173	10	MAVS	MAVS	NNPS
cord-254492-42d77vxf	173	11	in	in	IN
cord-254492-42d77vxf	173	12	the	the	DT
cord-254492-42d77vxf	173	13	RLR	RLR	NNP
cord-254492-42d77vxf	173	14	pathway	pathway	NN
cord-254492-42d77vxf	173	15	(	(	-LRB-
cord-254492-42d77vxf	173	16	Fig	Fig	NNP
cord-254492-42d77vxf	173	17	.	.	NNP
cord-254492-42d77vxf	173	18	2	2	CD
cord-254492-42d77vxf	173	19	,	,	,
cord-254492-42d77vxf	173	20	middle	middle	JJ
cord-254492-42d77vxf	173	21	)	)	-RRB-
cord-254492-42d77vxf	173	22	.	.	.
cord-254492-42d77vxf	174	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	174	2	,	,	,
cord-254492-42d77vxf	174	3	there	there	EX
cord-254492-42d77vxf	174	4	is	be	VBZ
cord-254492-42d77vxf	174	5	increasing	increase	VBG
cord-254492-42d77vxf	174	6	evidence	evidence	NN
cord-254492-42d77vxf	174	7	of	of	IN
cord-254492-42d77vxf	174	8	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	174	9	-	-	HYPH
cord-254492-42d77vxf	174	10	mediated	mediate	VBN
cord-254492-42d77vxf	174	11	cross	cross	NN
cord-254492-42d77vxf	174	12	-	-	NN
cord-254492-42d77vxf	174	13	talk	talk	NN
cord-254492-42d77vxf	174	14	between	between	IN
cord-254492-42d77vxf	174	15	TRAFs	traf	NNS
cord-254492-42d77vxf	174	16	.	.	.
cord-254492-42d77vxf	175	1	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	175	2	promotes	promote	VBZ
cord-254492-42d77vxf	175	3	IFN	IFN	NNP
cord-254492-42d77vxf	175	4	-	-	HYPH
cord-254492-42d77vxf	175	5	I	-PRON-	PRP
cord-254492-42d77vxf	175	6	expression	expression	NN
cord-254492-42d77vxf	175	7	by	by	IN
cord-254492-42d77vxf	175	8	activating	activate	VBG
cord-254492-42d77vxf	175	9	TBK1	TBK1	NNP
cord-254492-42d77vxf	175	10	/	/	SYM
cord-254492-42d77vxf	175	11	IRF3	IRF3	NNP
cord-254492-42d77vxf	176	1	(	(	-LRB-
cord-254492-42d77vxf	176	2	Parvatiyar	Parvatiyar	NNP
cord-254492-42d77vxf	176	3	et	et	NNP
cord-254492-42d77vxf	176	4	al	al	NNP
cord-254492-42d77vxf	176	5	.	.	NNP
cord-254492-42d77vxf	176	6	,	,	,
cord-254492-42d77vxf	176	7	2010	2010	CD
cord-254492-42d77vxf	176	8	)	)	-RRB-
cord-254492-42d77vxf	176	9	,	,	,
cord-254492-42d77vxf	176	10	whereas	whereas	IN
cord-254492-42d77vxf	176	11	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	176	12	activates	activate	VBZ
cord-254492-42d77vxf	177	1	mitogen	mitogen	NNP
cord-254492-42d77vxf	177	2	-	-	HYPH
cord-254492-42d77vxf	177	3	activated	activate	VBN
cord-254492-42d77vxf	177	4	protein	protein	NN
cord-254492-42d77vxf	177	5	kinase	kinase	NN
cord-254492-42d77vxf	177	6	kinase	kinase	VBZ
cord-254492-42d77vxf	177	7	kinase	kinase	VBZ
cord-254492-42d77vxf	177	8	1	1	CD
cord-254492-42d77vxf	178	1	(	(	-LRB-
cord-254492-42d77vxf	178	2	MEKK1	mekk1	NN
cord-254492-42d77vxf	178	3	)	)	-RRB-
cord-254492-42d77vxf	178	4	to	to	TO
cord-254492-42d77vxf	178	5	activate	activate	VB
cord-254492-42d77vxf	178	6	NF	NF	NNP
cord-254492-42d77vxf	178	7	-	-	HYPH
cord-254492-42d77vxf	178	8	κB	κB	NNP
cord-254492-42d77vxf	178	9	,	,	,
cord-254492-42d77vxf	178	10	which	which	WDT
cord-254492-42d77vxf	178	11	also	also	RB
cord-254492-42d77vxf	178	12	enhances	enhance	VBZ
cord-254492-42d77vxf	178	13	IFN	IFN	NNP
cord-254492-42d77vxf	178	14	-	-	HYPH
cord-254492-42d77vxf	178	15	I	-PRON-	PRP
cord-254492-42d77vxf	178	16	expression	expression	NN
cord-254492-42d77vxf	178	17	(	(	-LRB-
cord-254492-42d77vxf	178	18	Yoshida	Yoshida	NNP
cord-254492-42d77vxf	178	19	et	et	NNP
cord-254492-42d77vxf	178	20	al	al	NNP
cord-254492-42d77vxf	178	21	.	.	NNP
cord-254492-42d77vxf	178	22	,	,	,
cord-254492-42d77vxf	178	23	2008	2008	CD
cord-254492-42d77vxf	178	24	)	)	-RRB-
cord-254492-42d77vxf	178	25	.	.	.
cord-254492-42d77vxf	179	1	Simultaneously	simultaneously	RB
cord-254492-42d77vxf	179	2	,	,	,
cord-254492-42d77vxf	179	3	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	179	4	suppresses	suppress	VBZ
cord-254492-42d77vxf	179	5	NF	NF	NNP
cord-254492-42d77vxf	179	6	-	-	HYPH
cord-254492-42d77vxf	179	7	κB	κB	NNP
cord-254492-42d77vxf	179	8	by	by	IN
cord-254492-42d77vxf	179	9	inhibiting	inhibit	VBG
cord-254492-42d77vxf	179	10	IKK	IKK	NNP
cord-254492-42d77vxf	179	11	activation	activation	NN
cord-254492-42d77vxf	179	12	upon	upon	IN
cord-254492-42d77vxf	179	13	binding	bind	VBG
cord-254492-42d77vxf	179	14	TRAF2	traf2	XX
cord-254492-42d77vxf	180	1	(	(	-LRB-
cord-254492-42d77vxf	180	2	Zarnegar	Zarnegar	NNP
cord-254492-42d77vxf	180	3	et	et	FW
cord-254492-42d77vxf	180	4	al	al	NNP
cord-254492-42d77vxf	180	5	.	.	NNP
cord-254492-42d77vxf	180	6	,	,	,
cord-254492-42d77vxf	180	7	2008	2008	CD
cord-254492-42d77vxf	180	8	)	)	-RRB-
cord-254492-42d77vxf	180	9	,	,	,
cord-254492-42d77vxf	180	10	likely	likely	JJ
cord-254492-42d77vxf	180	11	as	as	IN
cord-254492-42d77vxf	180	12	a	a	DT
cord-254492-42d77vxf	180	13	mecha	mecha	NN
cord-254492-42d77vxf	180	14	-	-	HYPH
cord-254492-42d77vxf	180	15	nism	nism	NN
cord-254492-42d77vxf	180	16	to	to	TO
cord-254492-42d77vxf	180	17	skew	skew	VB
cord-254492-42d77vxf	180	18	innate	innate	JJ
cord-254492-42d77vxf	180	19	immune	immune	JJ
cord-254492-42d77vxf	180	20	effector	effector	NN
cord-254492-42d77vxf	180	21	molecule	molecule	NN
cord-254492-42d77vxf	180	22	expression	expression	NN
cord-254492-42d77vxf	180	23	as	as	IN
cord-254492-42d77vxf	180	24	required	require	VBN
cord-254492-42d77vxf	180	25	.	.	.
cord-254492-42d77vxf	181	1	Inversely	inversely	RB
cord-254492-42d77vxf	181	2	,	,	,
cord-254492-42d77vxf	181	3	the	the	DT
cord-254492-42d77vxf	181	4	E3	e3	NN
cord-254492-42d77vxf	181	5	cIAP2	ciap2	NN
cord-254492-42d77vxf	181	6	,	,	,
cord-254492-42d77vxf	181	7	after	after	IN
cord-254492-42d77vxf	181	8	itself	-PRON-	PRP
cord-254492-42d77vxf	181	9	being	be	VBG
cord-254492-42d77vxf	181	10	ubiquitinated	ubiquitinate	VBN
cord-254492-42d77vxf	181	11	by	by	IN
cord-254492-42d77vxf	181	12	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	181	13	,	,	,
cord-254492-42d77vxf	181	14	promotes	promote	VBZ
cord-254492-42d77vxf	181	15	TRAF3	traf3	NN
cord-254492-42d77vxf	181	16	degradation	degradation	NN
cord-254492-42d77vxf	181	17	by	by	IN
cord-254492-42d77vxf	181	18	ligating	ligate	VBG
cord-254492-42d77vxf	181	19	K48-linked	K48-linked	NNP
cord-254492-42d77vxf	181	20	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	181	21	chains	chain	NNS
cord-254492-42d77vxf	181	22	to	to	IN
cord-254492-42d77vxf	181	23	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	181	24	at	at	IN
cord-254492-42d77vxf	181	25	residues	residue	NNS
cord-254492-42d77vxf	181	26	K107	K107	NNP
cord-254492-42d77vxf	181	27	and	and	CC
cord-254492-42d77vxf	181	28	K156	K156	NNS
cord-254492-42d77vxf	181	29	,	,	,
cord-254492-42d77vxf	181	30	thereby	thereby	RB
cord-254492-42d77vxf	181	31	restoring	restore	VBG
cord-254492-42d77vxf	181	32	NF	nf	NN
cord-254492-42d77vxf	181	33	-	-	HYPH
cord-254492-42d77vxf	181	34	κB	κb	CD
cord-254492-42d77vxf	181	35	activation	activation	NN
cord-254492-42d77vxf	181	36	(	(	-LRB-
cord-254492-42d77vxf	181	37	Tseng	Tseng	NNP
cord-254492-42d77vxf	181	38	et	et	NNP
cord-254492-42d77vxf	181	39	al	al	NNP
cord-254492-42d77vxf	181	40	.	.	NNP
cord-254492-42d77vxf	181	41	,	,	,
cord-254492-42d77vxf	181	42	2010	2010	CD
cord-254492-42d77vxf	181	43	)	)	-RRB-
cord-254492-42d77vxf	181	44	.	.	.
cord-254492-42d77vxf	182	1	However	however	RB
cord-254492-42d77vxf	182	2	,	,	,
cord-254492-42d77vxf	182	3	as	as	RB
cord-254492-42d77vxf	182	4	well	well	RB
cord-254492-42d77vxf	182	5	as	as	IN
cord-254492-42d77vxf	182	6	degrading	degrade	VBG
cord-254492-42d77vxf	182	7	TRAF3	traf3	NN
cord-254492-42d77vxf	182	8	,	,	,
cord-254492-42d77vxf	182	9	cIAP1/2	cIAP1/2	NNP
cord-254492-42d77vxf	182	10	can	can	MD
cord-254492-42d77vxf	182	11	also	also	RB
cord-254492-42d77vxf	182	12	activate	activate	VB
cord-254492-42d77vxf	182	13	TRAF3	traf3	NN
cord-254492-42d77vxf	182	14	by	by	IN
cord-254492-42d77vxf	182	15	catalyzing	catalyze	VBG
cord-254492-42d77vxf	182	16	its	-PRON-	PRP$
cord-254492-42d77vxf	182	17	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	182	18	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	183	1	(	(	-LRB-
cord-254492-42d77vxf	183	2	Fig	Fig	NNP
cord-254492-42d77vxf	183	3	.	.	.
cord-254492-42d77vxf	184	1	3	3	LS
cord-254492-42d77vxf	184	2	;	;	:
cord-254492-42d77vxf	184	3	Mao	Mao	NNP
cord-254492-42d77vxf	184	4	et	et	NNP
cord-254492-42d77vxf	184	5	al	al	NNP
cord-254492-42d77vxf	184	6	.	.	NNP
cord-254492-42d77vxf	184	7	,	,	,
cord-254492-42d77vxf	184	8	2010	2010	CD
cord-254492-42d77vxf	184	9	)	)	-RRB-
cord-254492-42d77vxf	184	10	.	.	.
cord-254492-42d77vxf	185	1	This	this	DT
cord-254492-42d77vxf	185	2	suggests	suggest	VBZ
cord-254492-42d77vxf	185	3	that	that	IN
cord-254492-42d77vxf	185	4	the	the	DT
cord-254492-42d77vxf	185	5	context	context	NN
cord-254492-42d77vxf	185	6	-	-	HYPH
cord-254492-42d77vxf	185	7	dependent	dependent	JJ
cord-254492-42d77vxf	185	8	ubiquitination	ubiquitination	JJ
cord-254492-42d77vxf	185	9	state	state	NN
cord-254492-42d77vxf	185	10	of	of	IN
cord-254492-42d77vxf	185	11	cIAP1/2	cIAP1/2	NNP
cord-254492-42d77vxf	185	12	determines	determine	VBZ
cord-254492-42d77vxf	185	13	its	-PRON-	PRP$
cord-254492-42d77vxf	185	14	effect	effect	NN
cord-254492-42d77vxf	185	15	on	on	IN
cord-254492-42d77vxf	185	16	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	185	17	.	.	.
cord-254492-42d77vxf	186	1	The	the	DT
cord-254492-42d77vxf	186	2	E3	e3	NN
cord-254492-42d77vxf	186	3	RNF166	RNF166	NNP
cord-254492-42d77vxf	186	4	was	be	VBD
cord-254492-42d77vxf	186	5	recently	recently	RB
cord-254492-42d77vxf	186	6	reported	report	VBN
cord-254492-42d77vxf	186	7	to	to	IN
cord-254492-42d77vxf	186	8	ubiquitinate	ubiquitinate	NNP
cord-254492-42d77vxf	186	9	and	and	CC
cord-254492-42d77vxf	186	10	activate	activate	VB
cord-254492-42d77vxf	186	11	both	both	DT
cord-254492-42d77vxf	186	12	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	186	13	and	and	CC
cord-254492-42d77vxf	186	14	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	186	15	.	.	.
cord-254492-42d77vxf	187	1	Finally	finally	RB
cord-254492-42d77vxf	187	2	,	,	,
cord-254492-42d77vxf	187	3	the	the	DT
cord-254492-42d77vxf	187	4	RIG	rig	NN
cord-254492-42d77vxf	187	5	-	-	HYPH
cord-254492-42d77vxf	187	6	I	i	NN
cord-254492-42d77vxf	187	7	-	-	HYPH
cord-254492-42d77vxf	187	8	activating	activate	VBG
cord-254492-42d77vxf	187	9	E3	E3	NNP
cord-254492-42d77vxf	187	10	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	187	11	was	be	VBD
cord-254492-42d77vxf	187	12	reported	report	VBN
cord-254492-42d77vxf	187	13	to	to	TO
cord-254492-42d77vxf	187	14	enhance	enhance	VB
cord-254492-42d77vxf	187	15	MDA5-mediated	mda5-mediated	JJ
cord-254492-42d77vxf	187	16	NF	NF	NNP
cord-254492-42d77vxf	187	17	-	-	HYPH
cord-254492-42d77vxf	187	18	κB	κb	CD
cord-254492-42d77vxf	187	19	activation	activation	NN
cord-254492-42d77vxf	187	20	at	at	IN
cord-254492-42d77vxf	187	21	the	the	DT
cord-254492-42d77vxf	187	22	level	level	NN
cord-254492-42d77vxf	187	23	of	of	IN
cord-254492-42d77vxf	187	24	TRAF6	traf6	NN
cord-254492-42d77vxf	187	25	,	,	,
cord-254492-42d77vxf	187	26	although	although	IN
cord-254492-42d77vxf	187	27	mechanistic	mechanistic	JJ
cord-254492-42d77vxf	187	28	details	detail	NNS
cord-254492-42d77vxf	187	29	remain	remain	VBP
cord-254492-42d77vxf	187	30	unclear	unclear	JJ
cord-254492-42d77vxf	187	31	.	.	.
cord-254492-42d77vxf	188	1	TRAF	TRAF	NNP
cord-254492-42d77vxf	188	2	-	-	HYPH
cord-254492-42d77vxf	188	3	mediated	mediate	VBN
cord-254492-42d77vxf	188	4	signaling	signaling	NN
cord-254492-42d77vxf	188	5	is	be	VBZ
cord-254492-42d77vxf	188	6	also	also	RB
cord-254492-42d77vxf	188	7	terminated	terminate	VBN
cord-254492-42d77vxf	188	8	by	by	IN
cord-254492-42d77vxf	188	9	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	188	10	in	in	IN
cord-254492-42d77vxf	188	11	numerous	numerous	JJ
cord-254492-42d77vxf	188	12	ways	way	NNS
cord-254492-42d77vxf	188	13	.	.	.
cord-254492-42d77vxf	189	1	HSV	HSV	NNP
cord-254492-42d77vxf	189	2	encodes	encode	VBZ
cord-254492-42d77vxf	189	3	the	the	DT
cord-254492-42d77vxf	189	4	DUb	DUb	NNP
cord-254492-42d77vxf	189	5	UL36USP	UL36USP	NNP
cord-254492-42d77vxf	189	6	,	,	,
cord-254492-42d77vxf	189	7	which	which	WDT
cord-254492-42d77vxf	189	8	strips	strip	VBZ
cord-254492-42d77vxf	189	9	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	189	10	polyubiquitin	polyubiquitin	NNS
cord-254492-42d77vxf	189	11	chains	chain	NNS
cord-254492-42d77vxf	189	12	from	from	IN
cord-254492-42d77vxf	189	13	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	189	14	to	to	TO
cord-254492-42d77vxf	189	15	prevent	prevent	VB
cord-254492-42d77vxf	189	16	downstream	downstream	JJ
cord-254492-42d77vxf	189	17	protein	protein	NN
cord-254492-42d77vxf	189	18	recruitment	recruitment	NN
cord-254492-42d77vxf	189	19	(	(	-LRB-
cord-254492-42d77vxf	189	20	Fig	Fig	NNP
cord-254492-42d77vxf	189	21	.	.	.
cord-254492-42d77vxf	189	22	3	3	CD
cord-254492-42d77vxf	189	23	;	;	:
cord-254492-42d77vxf	189	24	Wang	Wang	NNP
cord-254492-42d77vxf	189	25	et	et	NNP
cord-254492-42d77vxf	189	26	al	al	NNP
cord-254492-42d77vxf	189	27	.	.	NNP
cord-254492-42d77vxf	189	28	,	,	,
cord-254492-42d77vxf	189	29	2013b	2013b	CD
cord-254492-42d77vxf	189	30	)	)	-RRB-
cord-254492-42d77vxf	189	31	,	,	,
cord-254492-42d77vxf	189	32	possibly	possibly	RB
cord-254492-42d77vxf	189	33	antagonizing	antagonize	VBG
cord-254492-42d77vxf	189	34	cIAP1/2-mediated	ciap1/2-mediate	VBN
cord-254492-42d77vxf	189	35	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	189	36	.	.	.
cord-254492-42d77vxf	190	1	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	191	1	and	and	CC
cord-254492-42d77vxf	191	2	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	191	3	are	be	VBP
cord-254492-42d77vxf	191	4	both	both	DT
cord-254492-42d77vxf	191	5	deactivated	deactivate	VBN
cord-254492-42d77vxf	191	6	by	by	IN
cord-254492-42d77vxf	191	7	the	the	DT
cord-254492-42d77vxf	191	8	DUbs	DUbs	NNP
cord-254492-42d77vxf	191	9	otubain	otubain	NN
cord-254492-42d77vxf	191	10	1	1	CD
cord-254492-42d77vxf	191	11	(	(	-LRB-
cord-254492-42d77vxf	191	12	OTUB1	otub1	NN
cord-254492-42d77vxf	191	13	)	)	-RRB-
cord-254492-42d77vxf	192	1	and	and	CC
cord-254492-42d77vxf	192	2	OTUB2	OTUB2	NNP
cord-254492-42d77vxf	192	3	,	,	,
cord-254492-42d77vxf	192	4	which	which	WDT
cord-254492-42d77vxf	192	5	remove	remove	VBP
cord-254492-42d77vxf	192	6	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	192	7	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	192	8	chains	chain	NNS
cord-254492-42d77vxf	192	9	(	(	-LRB-
cord-254492-42d77vxf	192	10	Li	Li	NNP
cord-254492-42d77vxf	192	11	et	et	NNP
cord-254492-42d77vxf	192	12	al	al	NNP
cord-254492-42d77vxf	192	13	.	.	NNP
cord-254492-42d77vxf	192	14	,	,	,
cord-254492-42d77vxf	192	15	2010b	2010b	CD
cord-254492-42d77vxf	192	16	)	)	-RRB-
cord-254492-42d77vxf	192	17	.	.	.
cord-254492-42d77vxf	193	1	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	193	2	is	be	VBZ
cord-254492-42d77vxf	193	3	further	further	RB
cord-254492-42d77vxf	193	4	deactivated	deactivate	VBN
cord-254492-42d77vxf	193	5	by	by	IN
cord-254492-42d77vxf	193	6	the	the	DT
cord-254492-42d77vxf	193	7	deubiquitinase	deubiquitinase	NN
cord-254492-42d77vxf	193	8	DUBA	DUBA	NNP
cord-254492-42d77vxf	193	9	,	,	,
cord-254492-42d77vxf	193	10	which	which	WDT
cord-254492-42d77vxf	193	11	removes	remove	VBZ
cord-254492-42d77vxf	193	12	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	193	13	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	193	14	chains	chain	NNS
cord-254492-42d77vxf	193	15	from	from	IN
cord-254492-42d77vxf	193	16	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	194	1	(	(	-LRB-
cord-254492-42d77vxf	194	2	Kayagaki	Kayagaki	NNP
cord-254492-42d77vxf	194	3	et	et	NNP
cord-254492-42d77vxf	194	4	al	al	NNP
cord-254492-42d77vxf	194	5	.	.	NNP
cord-254492-42d77vxf	194	6	,	,	,
cord-254492-42d77vxf	194	7	2007	2007	CD
cord-254492-42d77vxf	194	8	)	)	-RRB-
cord-254492-42d77vxf	194	9	.	.	.
cord-254492-42d77vxf	195	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	195	2	,	,	,
cord-254492-42d77vxf	195	3	the	the	DT
cord-254492-42d77vxf	195	4	E3	E3	NNP
cord-254492-42d77vxf	195	5	Triad3A	Triad3A	NNP
cord-254492-42d77vxf	195	6	redirects	redirect	VBZ
cord-254492-42d77vxf	195	7	TRAF3	traf3	NN
cord-254492-42d77vxf	195	8	to	to	IN
cord-254492-42d77vxf	195	9	the	the	DT
cord-254492-42d77vxf	195	10	proteasome	proteasome	NN
cord-254492-42d77vxf	195	11	by	by	IN
cord-254492-42d77vxf	195	12	ligating	ligate	VBG
cord-254492-42d77vxf	195	13	K48-linked	K48-linked	NNP
cord-254492-42d77vxf	195	14	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	195	15	chains	chain	NNS
cord-254492-42d77vxf	196	1	(	(	-LRB-
cord-254492-42d77vxf	196	2	Nakhaei	Nakhaei	NNP
cord-254492-42d77vxf	196	3	et	et	NNP
cord-254492-42d77vxf	196	4	al	al	NNP
cord-254492-42d77vxf	196	5	.	.	NNP
cord-254492-42d77vxf	196	6	,	,	,
cord-254492-42d77vxf	196	7	2009	2009	CD
cord-254492-42d77vxf	196	8	)	)	-RRB-
cord-254492-42d77vxf	196	9	.	.	.
cord-254492-42d77vxf	197	1	Altogether	altogether	RB
cord-254492-42d77vxf	197	2	,	,	,
cord-254492-42d77vxf	197	3	this	this	DT
cord-254492-42d77vxf	197	4	constitutes	constitute	VBZ
cord-254492-42d77vxf	197	5	a	a	DT
cord-254492-42d77vxf	197	6	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	197	7	-	-	HYPH
cord-254492-42d77vxf	197	8	dependent	dependent	JJ
cord-254492-42d77vxf	197	9	feedback	feedback	NN
cord-254492-42d77vxf	197	10	mechanism	mechanism	NN
cord-254492-42d77vxf	197	11	that	that	WDT
cord-254492-42d77vxf	197	12	enables	enable	VBZ
cord-254492-42d77vxf	197	13	TRAFs	traf	NNS
cord-254492-42d77vxf	197	14	to	to	TO
cord-254492-42d77vxf	197	15	dictate	dictate	VB
cord-254492-42d77vxf	197	16	the	the	DT
cord-254492-42d77vxf	197	17	direction	direction	NN
cord-254492-42d77vxf	197	18	of	of	IN
cord-254492-42d77vxf	197	19	immune	immune	JJ
cord-254492-42d77vxf	197	20	signal	signal	NN
cord-254492-42d77vxf	197	21	transmission	transmission	NN
cord-254492-42d77vxf	197	22	in	in	IN
cord-254492-42d77vxf	197	23	a	a	DT
cord-254492-42d77vxf	197	24	context	context	NN
cord-254492-42d77vxf	197	25	-	-	HYPH
cord-254492-42d77vxf	197	26	dependent	dependent	JJ
cord-254492-42d77vxf	197	27	manner	manner	NN
cord-254492-42d77vxf	197	28	.	.	.
cord-254492-42d77vxf	198	1	In	in	IN
cord-254492-42d77vxf	198	2	contrast	contrast	NN
cord-254492-42d77vxf	198	3	to	to	IN
cord-254492-42d77vxf	198	4	the	the	DT
cord-254492-42d77vxf	198	5	three	three	CD
cord-254492-42d77vxf	198	6	RLR	RLR	NNP
cord-254492-42d77vxf	198	7	receptors	receptor	NNS
cord-254492-42d77vxf	198	8	,	,	,
cord-254492-42d77vxf	198	9	the	the	DT
cord-254492-42d77vxf	198	10	22	22	CD
cord-254492-42d77vxf	198	11	NLRs	nlr	NNS
cord-254492-42d77vxf	198	12	have	have	VBP
cord-254492-42d77vxf	198	13	diverse	diverse	JJ
cord-254492-42d77vxf	198	14	expression	expression	NN
cord-254492-42d77vxf	198	15	patterns	pattern	NNS
cord-254492-42d77vxf	198	16	and	and	CC
cord-254492-42d77vxf	198	17	largely	largely	RB
cord-254492-42d77vxf	198	18	under	under	RB
cord-254492-42d77vxf	198	19	-	-	HYPH
cord-254492-42d77vxf	198	20	characterized	characterize	VBN
cord-254492-42d77vxf	198	21	functions	function	NNS
cord-254492-42d77vxf	198	22	.	.	.
cord-254492-42d77vxf	199	1	The	the	DT
cord-254492-42d77vxf	199	2	NLRs	nlr	NNS
cord-254492-42d77vxf	199	3	are	be	VBP
cord-254492-42d77vxf	199	4	well	well	RB
cord-254492-42d77vxf	199	5	recognized	recognize	VBN
cord-254492-42d77vxf	199	6	for	for	IN
cord-254492-42d77vxf	199	7	their	-PRON-	PRP$
cord-254492-42d77vxf	199	8	roles	role	NNS
cord-254492-42d77vxf	199	9	in	in	IN
cord-254492-42d77vxf	199	10	regulating	regulate	VBG
cord-254492-42d77vxf	199	11	NF	nf	NN
cord-254492-42d77vxf	199	12	-	-	HYPH
cord-254492-42d77vxf	199	13	κB	κb	CD
cord-254492-42d77vxf	199	14	activation	activation	NN
cord-254492-42d77vxf	199	15	and	and	CC
cord-254492-42d77vxf	199	16	antibacterial	antibacterial	JJ
cord-254492-42d77vxf	199	17	immunity	immunity	NN
cord-254492-42d77vxf	199	18	;	;	:
cord-254492-42d77vxf	199	19	however	however	RB
cord-254492-42d77vxf	199	20	,	,	,
cord-254492-42d77vxf	199	21	at	at	RB
cord-254492-42d77vxf	199	22	least	least	RBS
cord-254492-42d77vxf	199	23	five	five	CD
cord-254492-42d77vxf	199	24	members	member	NNS
cord-254492-42d77vxf	199	25	have	have	VBP
cord-254492-42d77vxf	199	26	emerging	emerge	VBG
cord-254492-42d77vxf	199	27	roles	role	NNS
cord-254492-42d77vxf	199	28	in	in	IN
cord-254492-42d77vxf	199	29	antiviral	antiviral	JJ
cord-254492-42d77vxf	199	30	immune	immune	NN
cord-254492-42d77vxf	199	31	signaling	signaling	NN
cord-254492-42d77vxf	199	32	:	:	:
cord-254492-42d77vxf	199	33	NOD1	NOD1	NNP
cord-254492-42d77vxf	199	34	,	,	,
cord-254492-42d77vxf	199	35	NOD2	NOD2	NNPS
cord-254492-42d77vxf	199	36	,	,	,
cord-254492-42d77vxf	199	37	NLRC5	NLRC5	NNP
cord-254492-42d77vxf	200	1	(	(	-LRB-
cord-254492-42d77vxf	200	2	NLR	NLR	NNP
cord-254492-42d77vxf	200	3	family	family	NN
cord-254492-42d77vxf	200	4	CARD	card	NN
cord-254492-42d77vxf	200	5	domain	domain	NN
cord-254492-42d77vxf	200	6	-	-	HYPH
cord-254492-42d77vxf	200	7	containing	contain	VBG
cord-254492-42d77vxf	200	8	protein	protein	NN
cord-254492-42d77vxf	200	9	5	5	CD
cord-254492-42d77vxf	200	10	)	)	-RRB-
cord-254492-42d77vxf	200	11	,	,	.
cord-254492-42d77vxf	201	1	NLRP4	NLRP4	NNP
cord-254492-42d77vxf	202	1	(	(	-LRB-
cord-254492-42d77vxf	202	2	NAC	NAC	NNP
cord-254492-42d77vxf	202	3	HT	HT	NNP
cord-254492-42d77vxf	202	4	,	,	,
cord-254492-42d77vxf	202	5	LRR	LRR	NNP
cord-254492-42d77vxf	202	6	,	,	,
cord-254492-42d77vxf	202	7	and	and	CC
cord-254492-42d77vxf	202	8	PYD	PYD	NNP
cord-254492-42d77vxf	202	9	domain	domain	NN
cord-254492-42d77vxf	202	10	-	-	HYPH
cord-254492-42d77vxf	202	11	containing	contain	VBG
cord-254492-42d77vxf	202	12	protein	protein	NN
cord-254492-42d77vxf	202	13	4	4	CD
cord-254492-42d77vxf	202	14	)	)	-RRB-
cord-254492-42d77vxf	202	15	,	,	,
cord-254492-42d77vxf	202	16	and	and	CC
cord-254492-42d77vxf	202	17	NLRX1	NLRX1	NNP
cord-254492-42d77vxf	203	1	(	(	-LRB-
cord-254492-42d77vxf	203	2	NLR	NLR	NNP
cord-254492-42d77vxf	203	3	family	family	NN
cord-254492-42d77vxf	203	4	member	member	NN
cord-254492-42d77vxf	203	5	X1	X1	NNP
cord-254492-42d77vxf	203	6	;	;	:
cord-254492-42d77vxf	203	7	Fig	Fig	NNP
cord-254492-42d77vxf	203	8	.	.	NNP
cord-254492-42d77vxf	203	9	2	2	CD
cord-254492-42d77vxf	203	10	,	,	,
cord-254492-42d77vxf	203	11	right	right	RB
cord-254492-42d77vxf	203	12	)	)	-RRB-
cord-254492-42d77vxf	203	13	.	.	.
cord-254492-42d77vxf	204	1	Although	although	IN
cord-254492-42d77vxf	204	2	NLRs	nlr	NNS
cord-254492-42d77vxf	204	3	recruit	recruit	VBP
cord-254492-42d77vxf	204	4	E3s	e3s	NN
cord-254492-42d77vxf	204	5	and	and	CC
cord-254492-42d77vxf	204	6	modulate	modulate	VB
cord-254492-42d77vxf	204	7	the	the	DT
cord-254492-42d77vxf	204	8	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	204	9	of	of	IN
cord-254492-42d77vxf	204	10	other	other	JJ
cord-254492-42d77vxf	204	11	proteins	protein	NNS
cord-254492-42d77vxf	204	12	,	,	,
cord-254492-42d77vxf	204	13	including	include	VBG
cord-254492-42d77vxf	204	14	several	several	JJ
cord-254492-42d77vxf	204	15	in	in	IN
cord-254492-42d77vxf	204	16	the	the	DT
cord-254492-42d77vxf	204	17	RLR	RLR	NNP
cord-254492-42d77vxf	204	18	cascade	cascade	NN
cord-254492-42d77vxf	204	19	,	,	,
cord-254492-42d77vxf	204	20	the	the	DT
cord-254492-42d77vxf	204	21	role	role	NN
cord-254492-42d77vxf	204	22	of	of	IN
cord-254492-42d77vxf	204	23	PTMs	ptm	NNS
cord-254492-42d77vxf	204	24	in	in	IN
cord-254492-42d77vxf	204	25	NLR	NLR	NNP
cord-254492-42d77vxf	204	26	regulation	regulation	NN
cord-254492-42d77vxf	204	27	remains	remain	VBZ
cord-254492-42d77vxf	204	28	under	under	IN
cord-254492-42d77vxf	204	29	-	-	HYPH
cord-254492-42d77vxf	204	30	defined	define	VBN
cord-254492-42d77vxf	204	31	.	.	.
cord-254492-42d77vxf	205	1	NLR	NLR	NNP
cord-254492-42d77vxf	205	2	regulation	regulation	NN
cord-254492-42d77vxf	205	3	and	and	CC
cord-254492-42d77vxf	205	4	innate	innate	JJ
cord-254492-42d77vxf	205	5	immune	immune	JJ
cord-254492-42d77vxf	205	6	signaling	signal	VBG
cord-254492-42d77vxf	205	7	cross	cross	NN
cord-254492-42d77vxf	205	8	-	-	NN
cord-254492-42d77vxf	205	9	talk	talk	NN
cord-254492-42d77vxf	205	10	.	.	.
cord-254492-42d77vxf	206	1	The	the	DT
cord-254492-42d77vxf	206	2	PRRs	prr	NNS
cord-254492-42d77vxf	206	3	NOD1	NOD1	NNP
cord-254492-42d77vxf	206	4	and	and	CC
cord-254492-42d77vxf	206	5	NOD2	NOD2	NNPS
cord-254492-42d77vxf	206	6	are	be	VBP
cord-254492-42d77vxf	206	7	the	the	DT
cord-254492-42d77vxf	206	8	best	well	RBS
cord-254492-42d77vxf	206	9	characterized	characterize	VBN
cord-254492-42d77vxf	206	10	NLRs	nlr	NNS
cord-254492-42d77vxf	206	11	.	.	.
cord-254492-42d77vxf	207	1	NOD1	NOD1	NNP
cord-254492-42d77vxf	207	2	is	be	VBZ
cord-254492-42d77vxf	207	3	expressed	express	VBN
cord-254492-42d77vxf	207	4	ubiquitously	ubiquitously	RB
cord-254492-42d77vxf	207	5	,	,	,
cord-254492-42d77vxf	207	6	whereas	whereas	IN
cord-254492-42d77vxf	207	7	NOD2	NOD2	NNP
cord-254492-42d77vxf	207	8	is	be	VBZ
cord-254492-42d77vxf	207	9	expressed	express	VBN
cord-254492-42d77vxf	207	10	mainly	mainly	RB
cord-254492-42d77vxf	207	11	in	in	IN
cord-254492-42d77vxf	207	12	cells	cell	NNS
cord-254492-42d77vxf	207	13	of	of	IN
cord-254492-42d77vxf	207	14	myeloid	myeloid	JJ
cord-254492-42d77vxf	207	15	and	and	CC
cord-254492-42d77vxf	207	16	lymphoid	lymphoid	JJ
cord-254492-42d77vxf	207	17	origin	origin	NN
cord-254492-42d77vxf	207	18	and	and	CC
cord-254492-42d77vxf	207	19	is	be	VBZ
cord-254492-42d77vxf	207	20	up	up	RB
cord-254492-42d77vxf	207	21	-	-	HYPH
cord-254492-42d77vxf	207	22	regulated	regulate	VBN
cord-254492-42d77vxf	207	23	during	during	IN
cord-254492-42d77vxf	207	24	bacterial	bacterial	JJ
cord-254492-42d77vxf	207	25	and	and	CC
cord-254492-42d77vxf	207	26	viral	viral	JJ
cord-254492-42d77vxf	207	27	infection	infection	NN
cord-254492-42d77vxf	207	28	.	.	.
cord-254492-42d77vxf	208	1	The	the	DT
cord-254492-42d77vxf	208	2	classic	classic	JJ
cord-254492-42d77vxf	208	3	NOD2-activating	NOD2-activating	NNP
cord-254492-42d77vxf	208	4	ligand	ligand	NN
cord-254492-42d77vxf	208	5	is	be	VBZ
cord-254492-42d77vxf	208	6	bacterial	bacterial	JJ
cord-254492-42d77vxf	208	7	muramyl	muramyl	NNP
cord-254492-42d77vxf	208	8	dipeptide	dipeptide	NNP
cord-254492-42d77vxf	208	9	(	(	-LRB-
cord-254492-42d77vxf	208	10	MDP	MDP	NNP
cord-254492-42d77vxf	208	11	)	)	-RRB-
cord-254492-42d77vxf	208	12	,	,	,
cord-254492-42d77vxf	208	13	which	which	WDT
cord-254492-42d77vxf	208	14	promotes	promote	VBZ
cord-254492-42d77vxf	208	15	NF	NF	NNP
cord-254492-42d77vxf	208	16	-	-	HYPH
cord-254492-42d77vxf	208	17	κB	κb	CD
cord-254492-42d77vxf	208	18	activation	activation	NN
cord-254492-42d77vxf	208	19	.	.	.
cord-254492-42d77vxf	209	1	However	however	RB
cord-254492-42d77vxf	209	2	,	,	,
cord-254492-42d77vxf	209	3	NOD2	NOD2	NNP
cord-254492-42d77vxf	209	4	also	also	RB
cord-254492-42d77vxf	209	5	promotes	promote	VBZ
cord-254492-42d77vxf	209	6	IFN	IFN	NNP
cord-254492-42d77vxf	209	7	-	-	HYPH
cord-254492-42d77vxf	209	8	I	-PRON-	PRP
cord-254492-42d77vxf	209	9	expression	expression	NN
cord-254492-42d77vxf	209	10	during	during	IN
cord-254492-42d77vxf	209	11	infection	infection	NN
cord-254492-42d77vxf	209	12	by	by	IN
cord-254492-42d77vxf	209	13	numerous	numerous	JJ
cord-254492-42d77vxf	209	14	RNA	RNA	NNP
cord-254492-42d77vxf	209	15	viruses	virus	NNS
cord-254492-42d77vxf	209	16	,	,	,
cord-254492-42d77vxf	209	17	in	in	IN
cord-254492-42d77vxf	209	18	part	part	NN
cord-254492-42d77vxf	209	19	through	through	IN
cord-254492-42d77vxf	209	20	recognizing	recognize	VBG
cord-254492-42d77vxf	209	21	single	single	RB
cord-254492-42d77vxf	209	22	-	-	HYPH
cord-254492-42d77vxf	209	23	stranded	strand	VBN
cord-254492-42d77vxf	209	24	RNA	RNA	NNP
cord-254492-42d77vxf	209	25	(	(	-LRB-
cord-254492-42d77vxf	209	26	ssRNA	ssrna	NN
cord-254492-42d77vxf	209	27	)	)	-RRB-
cord-254492-42d77vxf	209	28	and	and	CC
cord-254492-42d77vxf	209	29	interacting	interact	VBG
cord-254492-42d77vxf	209	30	with	with	IN
cord-254492-42d77vxf	209	31	MAVS	MAVS	NNPS
cord-254492-42d77vxf	209	32	.	.	.
cord-254492-42d77vxf	210	1	NOD2	NOD2	NNP
cord-254492-42d77vxf	210	2	may	may	MD
cord-254492-42d77vxf	210	3	also	also	RB
cord-254492-42d77vxf	210	4	promote	promote	VB
cord-254492-42d77vxf	210	5	IFN	IFN	NNP
cord-254492-42d77vxf	210	6	-	-	HYPH
cord-254492-42d77vxf	210	7	I	-PRON-	PRP
cord-254492-42d77vxf	210	8	expression	expression	NN
cord-254492-42d77vxf	210	9	during	during	IN
cord-254492-42d77vxf	210	10	infection	infection	NN
cord-254492-42d77vxf	210	11	by	by	IN
cord-254492-42d77vxf	210	12	particular	particular	JJ
cord-254492-42d77vxf	210	13	DNA	dna	NN
cord-254492-42d77vxf	210	14	viruses	virus	NNS
cord-254492-42d77vxf	210	15	by	by	IN
cord-254492-42d77vxf	210	16	an	an	DT
cord-254492-42d77vxf	210	17	undefined	undefined	JJ
cord-254492-42d77vxf	210	18	mechanism	mechanism	NN
cord-254492-42d77vxf	210	19	(	(	-LRB-
cord-254492-42d77vxf	210	20	Sabbah	Sabbah	NNP
cord-254492-42d77vxf	210	21	et	et	FW
cord-254492-42d77vxf	210	22	al	al	NNP
cord-254492-42d77vxf	210	23	.	.	NNP
cord-254492-42d77vxf	210	24	,	,	,
cord-254492-42d77vxf	210	25	2009	2009	CD
cord-254492-42d77vxf	210	26	;	;	:
cord-254492-42d77vxf	210	27	Kapoor	Kapoor	NNP
cord-254492-42d77vxf	210	28	et	et	NNP
cord-254492-42d77vxf	210	29	al	al	NNP
cord-254492-42d77vxf	210	30	.	.	NNP
cord-254492-42d77vxf	210	31	,	,	,
cord-254492-42d77vxf	210	32	2014	2014	CD
cord-254492-42d77vxf	210	33	)	)	-RRB-
cord-254492-42d77vxf	210	34	.	.	.
cord-254492-42d77vxf	211	1	Accordingly	accordingly	RB
cord-254492-42d77vxf	211	2	,	,	,
cord-254492-42d77vxf	211	3	NOD2	NOD2	NNP
cord-254492-42d77vxf	211	4	dysfunction	dysfunction	NN
cord-254492-42d77vxf	211	5	leads	lead	VBZ
cord-254492-42d77vxf	211	6	to	to	IN
cord-254492-42d77vxf	211	7	inefficient	inefficient	JJ
cord-254492-42d77vxf	211	8	innate	innate	JJ
cord-254492-42d77vxf	211	9	and	and	CC
cord-254492-42d77vxf	211	10	adaptive	adaptive	JJ
cord-254492-42d77vxf	211	11	immune	immune	JJ
cord-254492-42d77vxf	211	12	responses	response	NNS
cord-254492-42d77vxf	211	13	to	to	IN
cord-254492-42d77vxf	211	14	viral	viral	JJ
cord-254492-42d77vxf	211	15	infection	infection	NN
cord-254492-42d77vxf	211	16	(	(	-LRB-
cord-254492-42d77vxf	211	17	Lupfer	Lupfer	NNP
cord-254492-42d77vxf	211	18	et	et	FW
cord-254492-42d77vxf	211	19	al	al	NNP
cord-254492-42d77vxf	211	20	.	.	NNP
cord-254492-42d77vxf	211	21	,	,	,
cord-254492-42d77vxf	211	22	2014	2014	CD
cord-254492-42d77vxf	211	23	)	)	-RRB-
cord-254492-42d77vxf	211	24	.	.	.
cord-254492-42d77vxf	212	1	NOD2	NOD2	NNS
cord-254492-42d77vxf	212	2	features	feature	VBZ
cord-254492-42d77vxf	212	3	regularly	regularly	RB
cord-254492-42d77vxf	212	4	in	in	IN
cord-254492-42d77vxf	212	5	the	the	DT
cord-254492-42d77vxf	212	6	immune	immune	JJ
cord-254492-42d77vxf	212	7	signaling	signal	VBG
cord-254492-42d77vxf	212	8	landscape	landscape	NN
cord-254492-42d77vxf	212	9	,	,	,
cord-254492-42d77vxf	212	10	yet	yet	CC
cord-254492-42d77vxf	212	11	mechanisms	mechanism	NNS
cord-254492-42d77vxf	212	12	of	of	IN
cord-254492-42d77vxf	212	13	NOD2	NOD2	NNP
cord-254492-42d77vxf	212	14	regulation	regulation	NN
cord-254492-42d77vxf	212	15	and	and	CC
cord-254492-42d77vxf	212	16	cross	cross	NN
cord-254492-42d77vxf	212	17	-	-	NN
cord-254492-42d77vxf	212	18	talk	talk	NN
cord-254492-42d77vxf	212	19	are	be	VBP
cord-254492-42d77vxf	212	20	only	only	RB
cord-254492-42d77vxf	212	21	beginning	begin	VBG
cord-254492-42d77vxf	212	22	to	to	TO
cord-254492-42d77vxf	212	23	be	be	VB
cord-254492-42d77vxf	212	24	revealed	reveal	VBN
cord-254492-42d77vxf	212	25	.	.	.
cord-254492-42d77vxf	213	1	Upon	upon	IN
cord-254492-42d77vxf	213	2	activation	activation	NN
cord-254492-42d77vxf	213	3	by	by	IN
cord-254492-42d77vxf	213	4	MDP	MDP	NNP
cord-254492-42d77vxf	213	5	,	,	,
cord-254492-42d77vxf	213	6	NOD2	NOD2	NNP
cord-254492-42d77vxf	213	7	is	be	VBZ
cord-254492-42d77vxf	213	8	ubiquitinated	ubiquitinate	VBN
cord-254492-42d77vxf	213	9	by	by	IN
cord-254492-42d77vxf	213	10	TRIM27	TRIM27	NNP
cord-254492-42d77vxf	213	11	,	,	,
cord-254492-42d77vxf	213	12	leading	lead	VBG
cord-254492-42d77vxf	213	13	to	to	IN
cord-254492-42d77vxf	213	14	NOD2	NOD2	NNP
cord-254492-42d77vxf	213	15	degradation	degradation	NN
cord-254492-42d77vxf	213	16	and	and	CC
cord-254492-42d77vxf	213	17	NF	nf	NN
cord-254492-42d77vxf	213	18	-	-	HYPH
cord-254492-42d77vxf	213	19	κB	κb	CD
cord-254492-42d77vxf	213	20	inhibition	inhibition	NN
cord-254492-42d77vxf	213	21	(	(	-LRB-
cord-254492-42d77vxf	213	22	Zurek	Zurek	NNP
cord-254492-42d77vxf	213	23	et	et	NNP
cord-254492-42d77vxf	213	24	al	al	NNP
cord-254492-42d77vxf	213	25	.	.	NNP
cord-254492-42d77vxf	213	26	,	,	,
cord-254492-42d77vxf	213	27	2012	2012	CD
cord-254492-42d77vxf	213	28	)	)	-RRB-
cord-254492-42d77vxf	213	29	.	.	.
cord-254492-42d77vxf	214	1	NOD2	NOD2	NNS
cord-254492-42d77vxf	214	2	signaling	signal	VBG
cord-254492-42d77vxf	214	3	is	be	VBZ
cord-254492-42d77vxf	214	4	further	further	RB
cord-254492-42d77vxf	214	5	suppressed	suppress	VBN
cord-254492-42d77vxf	214	6	by	by	IN
cord-254492-42d77vxf	214	7	AIP4	AIP4	NNP
cord-254492-42d77vxf	214	8	,	,	,
cord-254492-42d77vxf	214	9	which	which	WDT
cord-254492-42d77vxf	214	10	ubiquitinates	ubiquitinate	VBZ
cord-254492-42d77vxf	214	11	Lys209	Lys209	NNP
cord-254492-42d77vxf	214	12	of	of	IN
cord-254492-42d77vxf	214	13	receptor	receptor	NN
cord-254492-42d77vxf	214	14	-	-	HYPH
cord-254492-42d77vxf	214	15	interacting	interact	VBG
cord-254492-42d77vxf	214	16	serine	serine	NN
cord-254492-42d77vxf	214	17	/	/	SYM
cord-254492-42d77vxf	214	18	threonine	threonine	NN
cord-254492-42d77vxf	214	19	protein	protein	NN
cord-254492-42d77vxf	214	20	kinase	kinase	VBZ
cord-254492-42d77vxf	214	21	2	2	CD
cord-254492-42d77vxf	214	22	(	(	-LRB-
cord-254492-42d77vxf	214	23	RIPK2	RIPK2	NNP
cord-254492-42d77vxf	214	24	)	)	-RRB-
cord-254492-42d77vxf	214	25	,	,	,
cord-254492-42d77vxf	214	26	the	the	DT
cord-254492-42d77vxf	214	27	immediate	immediate	JJ
cord-254492-42d77vxf	214	28	downstream	downstream	NN
cord-254492-42d77vxf	214	29	interacting	interact	VBG
cord-254492-42d77vxf	214	30	partner	partner	NN
cord-254492-42d77vxf	214	31	of	of	IN
cord-254492-42d77vxf	214	32	NOD2	NOD2	NNP
cord-254492-42d77vxf	215	1	(	(	-LRB-
cord-254492-42d77vxf	215	2	Fig	Fig	NNP
cord-254492-42d77vxf	215	3	.	.	NNP
cord-254492-42d77vxf	215	4	2	2	CD
cord-254492-42d77vxf	215	5	,	,	,
cord-254492-42d77vxf	215	6	right	right	JJ
cord-254492-42d77vxf	215	7	;	;	.
cord-254492-42d77vxf	216	1	Tao	Tao	NNP
cord-254492-42d77vxf	216	2	et	et	NNP
cord-254492-42d77vxf	216	3	al	al	NNP
cord-254492-42d77vxf	216	4	.	.	NNP
cord-254492-42d77vxf	216	5	,	,	,
cord-254492-42d77vxf	216	6	2009	2009	CD
cord-254492-42d77vxf	216	7	)	)	-RRB-
cord-254492-42d77vxf	216	8	.	.	.
cord-254492-42d77vxf	217	1	Conversely	conversely	RB
cord-254492-42d77vxf	217	2	,	,	,
cord-254492-42d77vxf	217	3	NOD2-driven	NOD2-driven	NNP
cord-254492-42d77vxf	217	4	NF	NF	NNP
cord-254492-42d77vxf	217	5	-	-	HYPH
cord-254492-42d77vxf	217	6	κB	κb	CD
cord-254492-42d77vxf	217	7	activation	activation	NN
cord-254492-42d77vxf	217	8	is	be	VBZ
cord-254492-42d77vxf	217	9	enhanced	enhance	VBN
cord-254492-42d77vxf	217	10	by	by	IN
cord-254492-42d77vxf	217	11	LUB	LUB	NNP
cord-254492-42d77vxf	217	12	AC	AC	NNP
cord-254492-42d77vxf	217	13	,	,	,
cord-254492-42d77vxf	217	14	a	a	DT
cord-254492-42d77vxf	217	15	negative	negative	JJ
cord-254492-42d77vxf	217	16	regulator	regulator	NN
cord-254492-42d77vxf	217	17	of	of	IN
cord-254492-42d77vxf	217	18	RLR	RLR	NNP
cord-254492-42d77vxf	217	19	signaling	signaling	NN
cord-254492-42d77vxf	217	20	,	,	,
cord-254492-42d77vxf	217	21	as	as	RB
cord-254492-42d77vxf	217	22	well	well	RB
cord-254492-42d77vxf	217	23	as	as	IN
cord-254492-42d77vxf	217	24	X	x	NN
cord-254492-42d77vxf	217	25	-	-	HYPH
cord-254492-42d77vxf	217	26	linked	link	VBN
cord-254492-42d77vxf	217	27	IAP	IAP	NNP
cord-254492-42d77vxf	217	28	(	(	-LRB-
cord-254492-42d77vxf	217	29	XIAP	XIAP	NNP
cord-254492-42d77vxf	217	30	)	)	-RRB-
cord-254492-42d77vxf	217	31	,	,	,
cord-254492-42d77vxf	217	32	which	which	WDT
cord-254492-42d77vxf	217	33	respectively	respectively	RB
cord-254492-42d77vxf	217	34	ligate	ligate	VBP
cord-254492-42d77vxf	217	35	M1-and	m1-and	NN
cord-254492-42d77vxf	217	36	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	217	37	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	217	38	chains	chain	NNS
cord-254492-42d77vxf	217	39	to	to	IN
cord-254492-42d77vxf	217	40	NOD2	NOD2	NNP
cord-254492-42d77vxf	217	41	and	and	CC
cord-254492-42d77vxf	217	42	RIPK2	ripk2	XX
cord-254492-42d77vxf	218	1	(	(	-LRB-
cord-254492-42d77vxf	218	2	Damgaard	Damgaard	NNP
cord-254492-42d77vxf	218	3	et	et	NNP
cord-254492-42d77vxf	218	4	al	al	NNP
cord-254492-42d77vxf	218	5	.	.	NNP
cord-254492-42d77vxf	218	6	,	,	,
cord-254492-42d77vxf	218	7	2012	2012	CD
cord-254492-42d77vxf	218	8	)	)	-RRB-
cord-254492-42d77vxf	218	9	.	.	.
cord-254492-42d77vxf	219	1	These	these	DT
cord-254492-42d77vxf	219	2	activating	activate	VBG
cord-254492-42d77vxf	219	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	219	4	chains	chain	NNS
cord-254492-42d77vxf	219	5	may	may	MD
cord-254492-42d77vxf	219	6	be	be	VB
cord-254492-42d77vxf	219	7	antagonized	antagonize	VBN
cord-254492-42d77vxf	219	8	by	by	IN
cord-254492-42d77vxf	219	9	the	the	DT
cord-254492-42d77vxf	219	10	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	219	11	-	-	HYPH
cord-254492-42d77vxf	219	12	editing	editing	NN
cord-254492-42d77vxf	219	13	enzyme	enzyme	NN
cord-254492-42d77vxf	219	14	A20	A20	NNP
cord-254492-42d77vxf	219	15	,	,	,
cord-254492-42d77vxf	219	16	which	which	WDT
cord-254492-42d77vxf	219	17	also	also	RB
cord-254492-42d77vxf	219	18	disrupts	disrupt	VBZ
cord-254492-42d77vxf	219	19	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	219	20	-	-	HYPH
cord-254492-42d77vxf	219	21	mediated	mediate	VBN
cord-254492-42d77vxf	219	22	TBK1	TBK1	NNP
cord-254492-42d77vxf	219	23	activation	activation	NN
cord-254492-42d77vxf	219	24	in	in	IN
cord-254492-42d77vxf	219	25	the	the	DT
cord-254492-42d77vxf	219	26	RLR	RLR	NNP
cord-254492-42d77vxf	219	27	signaling	signal	VBG
cord-254492-42d77vxf	219	28	cascade	cascade	NN
cord-254492-42d77vxf	219	29	as	as	RB
cord-254492-42d77vxf	219	30	well	well	RB
cord-254492-42d77vxf	219	31	as	as	IN
cord-254492-42d77vxf	219	32	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	219	33	-	-	HYPH
cord-254492-42d77vxf	219	34	mediated	mediate	VBN
cord-254492-42d77vxf	219	35	TRAF6	traf6	NN
cord-254492-42d77vxf	219	36	activation	activation	NN
cord-254492-42d77vxf	219	37	in	in	IN
cord-254492-42d77vxf	219	38	the	the	DT
cord-254492-42d77vxf	219	39	TLR	TLR	NNP
cord-254492-42d77vxf	219	40	cascade	cascade	NN
cord-254492-42d77vxf	219	41	Parvatiyar	Parvatiyar	NNP
cord-254492-42d77vxf	219	42	et	et	NNP
cord-254492-42d77vxf	219	43	al	al	NNP
cord-254492-42d77vxf	219	44	.	.	NNP
cord-254492-42d77vxf	219	45	,	,	,
cord-254492-42d77vxf	219	46	2010	2010	CD
cord-254492-42d77vxf	219	47	)	)	-RRB-
cord-254492-42d77vxf	219	48	.	.	.
cord-254492-42d77vxf	220	1	Another	another	DT
cord-254492-42d77vxf	220	2	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	220	3	link	link	NN
cord-254492-42d77vxf	220	4	between	between	IN
cord-254492-42d77vxf	220	5	the	the	DT
cord-254492-42d77vxf	220	6	NLR	NLR	NNP
cord-254492-42d77vxf	220	7	and	and	CC
cord-254492-42d77vxf	220	8	RLR	RLR	NNP
cord-254492-42d77vxf	220	9	signaling	signal	VBG
cord-254492-42d77vxf	220	10	pathways	pathway	NNS
cord-254492-42d77vxf	220	11	is	be	VBZ
cord-254492-42d77vxf	220	12	the	the	DT
cord-254492-42d77vxf	220	13	ubiquitously	ubiquitously	RB
cord-254492-42d77vxf	220	14	expressed	express	VBN
cord-254492-42d77vxf	220	15	NLRX1	NLRX1	NNP
cord-254492-42d77vxf	221	1	(	(	-LRB-
cord-254492-42d77vxf	221	2	Fig	Fig	NNP
cord-254492-42d77vxf	221	3	.	.	NNP
cord-254492-42d77vxf	221	4	2	2	CD
cord-254492-42d77vxf	221	5	,	,	,
cord-254492-42d77vxf	221	6	right	right	JJ
cord-254492-42d77vxf	221	7	)	)	-RRB-
cord-254492-42d77vxf	221	8	,	,	,
cord-254492-42d77vxf	221	9	whose	whose	WP$
cord-254492-42d77vxf	221	10	role	role	NN
cord-254492-42d77vxf	221	11	in	in	IN
cord-254492-42d77vxf	221	12	IFN	IFN	NNP
cord-254492-42d77vxf	221	13	-	-	HYPH
cord-254492-42d77vxf	221	14	I	I	NNP
cord-254492-42d77vxf	221	15	regulation	regulation	NN
cord-254492-42d77vxf	221	16	is	be	VBZ
cord-254492-42d77vxf	221	17	controversial	controversial	JJ
cord-254492-42d77vxf	221	18	.	.	.
cord-254492-42d77vxf	222	1	NLRX1	NLRX1	NNP
cord-254492-42d77vxf	222	2	is	be	VBZ
cord-254492-42d77vxf	222	3	localized	localize	VBN
cord-254492-42d77vxf	222	4	to	to	IN
cord-254492-42d77vxf	222	5	the	the	DT
cord-254492-42d77vxf	222	6	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	222	7	outer	outer	JJ
cord-254492-42d77vxf	222	8	membrane	membrane	NN
cord-254492-42d77vxf	222	9	and	and	CC
cord-254492-42d77vxf	222	10	was	be	VBD
cord-254492-42d77vxf	222	11	reported	report	VBN
cord-254492-42d77vxf	222	12	to	to	TO
cord-254492-42d77vxf	222	13	inhibit	inhibit	VB
cord-254492-42d77vxf	223	1	MAVS	MAVS	NNP
cord-254492-42d77vxf	223	2	-	-	HYPH
cord-254492-42d77vxf	223	3	dependent	dependent	JJ
cord-254492-42d77vxf	223	4	IFN	IFN	NNP
cord-254492-42d77vxf	223	5	-	-	HYPH
cord-254492-42d77vxf	223	6	I	I	NNP
cord-254492-42d77vxf	223	7	signaling	signal	VBG
cord-254492-42d77vxf	223	8	by	by	IN
cord-254492-42d77vxf	223	9	blocking	block	VBG
cord-254492-42d77vxf	223	10	the	the	DT
cord-254492-42d77vxf	223	11	interaction	interaction	NN
cord-254492-42d77vxf	223	12	between	between	IN
cord-254492-42d77vxf	223	13	activated	activate	VBN
cord-254492-42d77vxf	223	14	RIG	rig	NN
cord-254492-42d77vxf	223	15	-	-	:
cord-254492-42d77vxf	223	16	I	I	NNP
cord-254492-42d77vxf	223	17	/	/	SYM
cord-254492-42d77vxf	223	18	MDA5	MDA5	NNP
cord-254492-42d77vxf	223	19	and	and	CC
cord-254492-42d77vxf	223	20	MAVS	MAVS	NNP
cord-254492-42d77vxf	223	21	,	,	,
cord-254492-42d77vxf	223	22	although	although	IN
cord-254492-42d77vxf	223	23	viral	viral	JJ
cord-254492-42d77vxf	223	24	replication	replication	NN
cord-254492-42d77vxf	223	25	experiments	experiment	NNS
cord-254492-42d77vxf	223	26	using	use	VBG
cord-254492-42d77vxf	223	27	gene	gene	NN
cord-254492-42d77vxf	223	28	knockout	knockout	NN
cord-254492-42d77vxf	223	29	cells	cell	NNS
cord-254492-42d77vxf	223	30	have	have	VBP
cord-254492-42d77vxf	223	31	produced	produce	VBN
cord-254492-42d77vxf	223	32	conflicting	conflicting	JJ
cord-254492-42d77vxf	223	33	results	result	NNS
cord-254492-42d77vxf	223	34	(	(	-LRB-
cord-254492-42d77vxf	223	35	Soares	Soares	NNP
cord-254492-42d77vxf	223	36	et	et	NNP
cord-254492-42d77vxf	223	37	al	al	NNP
cord-254492-42d77vxf	223	38	.	.	NNP
cord-254492-42d77vxf	223	39	,	,	,
cord-254492-42d77vxf	223	40	2013	2013	CD
cord-254492-42d77vxf	223	41	)	)	-RRB-
cord-254492-42d77vxf	223	42	.	.	.
cord-254492-42d77vxf	224	1	NLRX1	NLRX1	NNP
cord-254492-42d77vxf	224	2	also	also	RB
cord-254492-42d77vxf	224	3	potentiates	potentiate	VBZ
cord-254492-42d77vxf	224	4	NF	NF	NNP
cord-254492-42d77vxf	224	5	-	-	HYPH
cord-254492-42d77vxf	224	6	κB	κB	NNP
cord-254492-42d77vxf	224	7	signaling	signaling	NN
cord-254492-42d77vxf	224	8	by	by	IN
cord-254492-42d77vxf	224	9	promoting	promote	VBG
cord-254492-42d77vxf	224	10	reactive	reactive	JJ
cord-254492-42d77vxf	224	11	oxygen	oxygen	NN
cord-254492-42d77vxf	224	12	species	specie	NNS
cord-254492-42d77vxf	224	13	production	production	NN
cord-254492-42d77vxf	224	14	during	during	IN
cord-254492-42d77vxf	224	15	bacterial	bacterial	JJ
cord-254492-42d77vxf	224	16	infection	infection	NN
cord-254492-42d77vxf	224	17	,	,	,
cord-254492-42d77vxf	224	18	linking	link	VBG
cord-254492-42d77vxf	224	19	the	the	DT
cord-254492-42d77vxf	224	20	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	224	21	immune	immune	NN
cord-254492-42d77vxf	224	22	signaling	signal	VBG
cord-254492-42d77vxf	224	23	platform	platform	NN
cord-254492-42d77vxf	224	24	with	with	IN
cord-254492-42d77vxf	224	25	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	224	26	cytokine	cytokine	NN
cord-254492-42d77vxf	224	27	generation	generation	NN
cord-254492-42d77vxf	225	1	(	(	-LRB-
cord-254492-42d77vxf	225	2	Tattoli	Tattoli	NNP
cord-254492-42d77vxf	225	3	et	et	FW
cord-254492-42d77vxf	225	4	al	al	NNP
cord-254492-42d77vxf	225	5	.	.	NNP
cord-254492-42d77vxf	225	6	,	,	,
cord-254492-42d77vxf	225	7	2008	2008	CD
cord-254492-42d77vxf	225	8	)	)	-RRB-
cord-254492-42d77vxf	225	9	.	.	.
cord-254492-42d77vxf	226	1	NLRC5	NLRC5	NNP
cord-254492-42d77vxf	226	2	was	be	VBD
cord-254492-42d77vxf	226	3	initially	initially	RB
cord-254492-42d77vxf	226	4	described	describe	VBN
cord-254492-42d77vxf	226	5	to	to	TO
cord-254492-42d77vxf	226	6	enhance	enhance	VB
cord-254492-42d77vxf	226	7	IFN	IFN	NNP
cord-254492-42d77vxf	226	8	-	-	HYPH
cord-254492-42d77vxf	226	9	γ	γ	NNP
cord-254492-42d77vxf	226	10	and	and	CC
cord-254492-42d77vxf	226	11	IFN	IFN	NNP
cord-254492-42d77vxf	226	12	-	-	HYPH
cord-254492-42d77vxf	226	13	α	α	NNP
cord-254492-42d77vxf	226	14	expression	expression	NN
cord-254492-42d77vxf	226	15	and	and	CC
cord-254492-42d77vxf	226	16	inhibit	inhibit	VB
cord-254492-42d77vxf	226	17	NF	nf	NN
cord-254492-42d77vxf	226	18	-	-	HYPH
cord-254492-42d77vxf	226	19	κB	κB	NNP
cord-254492-42d77vxf	226	20	and	and	CC
cord-254492-42d77vxf	226	21	IFN	IFN	NNP
cord-254492-42d77vxf	226	22	-	-	HYPH
cord-254492-42d77vxf	226	23	β	β	NNP
cord-254492-42d77vxf	226	24	,	,	,
cord-254492-42d77vxf	226	25	in	in	IN
cord-254492-42d77vxf	226	26	the	the	DT
cord-254492-42d77vxf	226	27	latter	latter	JJ
cord-254492-42d77vxf	226	28	case	case	NN
cord-254492-42d77vxf	226	29	through	through	IN
cord-254492-42d77vxf	226	30	sequestering	sequester	VBG
cord-254492-42d77vxf	226	31	the	the	DT
cord-254492-42d77vxf	226	32	activated	activate	VBN
cord-254492-42d77vxf	226	33	effector	effector	NN
cord-254492-42d77vxf	226	34	domains	domain	NNS
cord-254492-42d77vxf	226	35	of	of	IN
cord-254492-42d77vxf	226	36	RIG	rig	NN
cord-254492-42d77vxf	226	37	-	-	:
cord-254492-42d77vxf	226	38	I	I	NNP
cord-254492-42d77vxf	226	39	and	and	CC
cord-254492-42d77vxf	226	40	MDA5	MDA5	NNP
cord-254492-42d77vxf	226	41	(	(	-LRB-
cord-254492-42d77vxf	226	42	Cui	Cui	NNP
cord-254492-42d77vxf	226	43	et	et	FW
cord-254492-42d77vxf	226	44	al	al	NNP
cord-254492-42d77vxf	226	45	.	.	NNP
cord-254492-42d77vxf	226	46	,	,	,
cord-254492-42d77vxf	226	47	2010	2010	CD
cord-254492-42d77vxf	226	48	;	;	:
cord-254492-42d77vxf	226	49	Kuenzel	Kuenzel	NNP
cord-254492-42d77vxf	226	50	et	et	NNP
cord-254492-42d77vxf	226	51	al	al	NNP
cord-254492-42d77vxf	226	52	.	.	NNP
cord-254492-42d77vxf	226	53	,	,	,
cord-254492-42d77vxf	226	54	2010	2010	CD
cord-254492-42d77vxf	226	55	)	)	-RRB-
cord-254492-42d77vxf	226	56	.	.	.
cord-254492-42d77vxf	227	1	NLRC5	NLRC5	NNP
cord-254492-42d77vxf	227	2	has	have	VBZ
cord-254492-42d77vxf	227	3	also	also	RB
cord-254492-42d77vxf	227	4	been	be	VBN
cord-254492-42d77vxf	227	5	shown	show	VBN
cord-254492-42d77vxf	227	6	to	to	TO
cord-254492-42d77vxf	227	7	bind	bind	VB
cord-254492-42d77vxf	227	8	and	and	CC
cord-254492-42d77vxf	227	9	inhibit	inhibit	VB
cord-254492-42d77vxf	227	10	TBK1mediated	TBK1mediated	NNP
cord-254492-42d77vxf	227	11	IFN	IFN	NNP
cord-254492-42d77vxf	227	12	-	-	HYPH
cord-254492-42d77vxf	227	13	β	β	NN
cord-254492-42d77vxf	227	14	induction	induction	NN
cord-254492-42d77vxf	227	15	in	in	IN
cord-254492-42d77vxf	227	16	HEK-293	HEK-293	NNP
cord-254492-42d77vxf	227	17	T	T	NNP
cord-254492-42d77vxf	227	18	cells	cell	NNS
cord-254492-42d77vxf	227	19	,	,	,
cord-254492-42d77vxf	227	20	although	although	IN
cord-254492-42d77vxf	227	21	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	227	22	−/−	−/−	NNP
cord-254492-42d77vxf	227	23	mice	mouse	NNS
cord-254492-42d77vxf	227	24	show	show	VBP
cord-254492-42d77vxf	227	25	relatively	relatively	RB
cord-254492-42d77vxf	227	26	normal	normal	JJ
cord-254492-42d77vxf	227	27	cytokine	cytokine	NN
cord-254492-42d77vxf	227	28	responses	response	NNS
cord-254492-42d77vxf	227	29	upon	upon	IN
cord-254492-42d77vxf	227	30	exposure	exposure	NN
cord-254492-42d77vxf	227	31	to	to	IN
cord-254492-42d77vxf	227	32	RLR-	RLR-	NNP
cord-254492-42d77vxf	227	33	,	,	,
cord-254492-42d77vxf	227	34	TLR-	TLR-	NNP
cord-254492-42d77vxf	227	35	,	,	,
cord-254492-42d77vxf	227	36	and	and	CC
cord-254492-42d77vxf	227	37	NLR	NLR	NNP
cord-254492-42d77vxf	227	38	-	-	HYPH
cord-254492-42d77vxf	227	39	activating	activate	VBG
cord-254492-42d77vxf	227	40	stimuli	stimulus	NNS
cord-254492-42d77vxf	227	41	(	(	-LRB-
cord-254492-42d77vxf	227	42	Kumar	Kumar	NNP
cord-254492-42d77vxf	227	43	et	et	NNP
cord-254492-42d77vxf	227	44	al	al	NNP
cord-254492-42d77vxf	227	45	.	.	NNP
cord-254492-42d77vxf	227	46	,	,	,
cord-254492-42d77vxf	227	47	2011	2011	CD
cord-254492-42d77vxf	227	48	)	)	-RRB-
cord-254492-42d77vxf	227	49	.	.	.
cord-254492-42d77vxf	228	1	Still	still	RB
cord-254492-42d77vxf	228	2	other	other	JJ
cord-254492-42d77vxf	228	3	findings	finding	NNS
cord-254492-42d77vxf	228	4	indicate	indicate	VBP
cord-254492-42d77vxf	228	5	that	that	IN
cord-254492-42d77vxf	228	6	the	the	DT
cord-254492-42d77vxf	228	7	RIG	rig	NN
cord-254492-42d77vxf	228	8	-I	-i	NN
cord-254492-42d77vxf	228	9	:	:	:
cord-254492-42d77vxf	228	10	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	228	11	interaction	interaction	NN
cord-254492-42d77vxf	228	12	also	also	RB
cord-254492-42d77vxf	228	13	positively	positively	RB
cord-254492-42d77vxf	228	14	regulates	regulate	VBZ
cord-254492-42d77vxf	228	15	IFN	IFN	NNP
cord-254492-42d77vxf	228	16	-	-	HYPH
cord-254492-42d77vxf	228	17	β	β	NNP
cord-254492-42d77vxf	228	18	expression	expression	NN
cord-254492-42d77vxf	228	19	,	,	,
cord-254492-42d77vxf	228	20	and	and	CC
cord-254492-42d77vxf	228	21	this	this	DT
cord-254492-42d77vxf	228	22	interaction	interaction	NN
cord-254492-42d77vxf	228	23	is	be	VBZ
cord-254492-42d77vxf	228	24	targeted	target	VBN
cord-254492-42d77vxf	228	25	by	by	IN
cord-254492-42d77vxf	228	26	the	the	DT
cord-254492-42d77vxf	228	27	IAV	IAV	NNP
cord-254492-42d77vxf	228	28	-	-	HYPH
cord-254492-42d77vxf	228	29	NS1	ns1	NN
cord-254492-42d77vxf	228	30	protein	protein	NN
cord-254492-42d77vxf	228	31	(	(	-LRB-
cord-254492-42d77vxf	228	32	Fig	Fig	NNP
cord-254492-42d77vxf	228	33	.	.	NNP
cord-254492-42d77vxf	228	34	2	2	CD
cord-254492-42d77vxf	228	35	,	,	,
cord-254492-42d77vxf	228	36	right	right	JJ
cord-254492-42d77vxf	228	37	;	;	.
cord-254492-42d77vxf	229	1	Neerincx	Neerincx	NNP
cord-254492-42d77vxf	229	2	et	et	NNP
cord-254492-42d77vxf	229	3	al	al	NNP
cord-254492-42d77vxf	229	4	.	.	NNP
cord-254492-42d77vxf	229	5	,	,	,
cord-254492-42d77vxf	229	6	2010	2010	CD
cord-254492-42d77vxf	229	7	;	;	:
cord-254492-42d77vxf	229	8	Ranjan	Ranjan	NNP
cord-254492-42d77vxf	229	9	et	et	NNP
cord-254492-42d77vxf	229	10	al	al	NNP
cord-254492-42d77vxf	229	11	.	.	NNP
cord-254492-42d77vxf	229	12	,	,	,
cord-254492-42d77vxf	229	13	2015	2015	CD
cord-254492-42d77vxf	229	14	)	)	-RRB-
cord-254492-42d77vxf	229	15	.	.	.
cord-254492-42d77vxf	230	1	These	these	DT
cord-254492-42d77vxf	230	2	disparate	disparate	JJ
cord-254492-42d77vxf	230	3	conclusions	conclusion	NNS
cord-254492-42d77vxf	230	4	may	may	MD
cord-254492-42d77vxf	230	5	reflect	reflect	VB
cord-254492-42d77vxf	230	6	cell	cell	NN
cord-254492-42d77vxf	230	7	-	-	HYPH
cord-254492-42d77vxf	230	8	specific	specific	JJ
cord-254492-42d77vxf	230	9	differences	difference	NNS
cord-254492-42d77vxf	230	10	given	give	VBN
cord-254492-42d77vxf	230	11	that	that	IN
cord-254492-42d77vxf	230	12	NLRC5	nlrc5	NN
cord-254492-42d77vxf	230	13	is	be	VBZ
cord-254492-42d77vxf	230	14	predominantly	predominantly	RB
cord-254492-42d77vxf	230	15	expressed	express	VBN
cord-254492-42d77vxf	230	16	in	in	IN
cord-254492-42d77vxf	230	17	hematopoietic	hematopoietic	JJ
cord-254492-42d77vxf	230	18	cells	cell	NNS
cord-254492-42d77vxf	230	19	or	or	CC
cord-254492-42d77vxf	230	20	differences	difference	NNS
cord-254492-42d77vxf	230	21	between	between	IN
cord-254492-42d77vxf	230	22	mouse	mouse	NN
cord-254492-42d77vxf	230	23	and	and	CC
cord-254492-42d77vxf	230	24	human	human	NN
cord-254492-42d77vxf	230	25	signaling	signal	VBG
cord-254492-42d77vxf	230	26	pathways	pathway	NNS
cord-254492-42d77vxf	230	27	,	,	,
cord-254492-42d77vxf	230	28	suggesting	suggest	VBG
cord-254492-42d77vxf	230	29	that	that	IN
cord-254492-42d77vxf	230	30	the	the	DT
cord-254492-42d77vxf	230	31	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	230	32	regulatory	regulatory	JJ
cord-254492-42d77vxf	230	33	framework	framework	NN
cord-254492-42d77vxf	230	34	is	be	VBZ
cord-254492-42d77vxf	230	35	complex	complex	JJ
cord-254492-42d77vxf	230	36	.	.	.
cord-254492-42d77vxf	231	1	Adding	add	VBG
cord-254492-42d77vxf	231	2	to	to	IN
cord-254492-42d77vxf	231	3	this	this	DT
cord-254492-42d77vxf	231	4	,	,	,
cord-254492-42d77vxf	231	5	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	231	6	plays	play	VBZ
cord-254492-42d77vxf	231	7	an	an	DT
cord-254492-42d77vxf	231	8	uncharacterized	uncharacterized	JJ
cord-254492-42d77vxf	231	9	role	role	NN
cord-254492-42d77vxf	231	10	in	in	IN
cord-254492-42d77vxf	231	11	regulating	regulate	VBG
cord-254492-42d77vxf	231	12	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	231	13	upon	upon	IN
cord-254492-42d77vxf	231	14	LPS	LPS	NNP
cord-254492-42d77vxf	231	15	stimulation	stimulation	NN
cord-254492-42d77vxf	231	16	and	and	CC
cord-254492-42d77vxf	231	17	may	may	MD
cord-254492-42d77vxf	231	18	be	be	VB
cord-254492-42d77vxf	231	19	induced	induce	VBN
cord-254492-42d77vxf	231	20	by	by	IN
cord-254492-42d77vxf	231	21	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	231	22	overexpression	overexpression	NN
cord-254492-42d77vxf	231	23	(	(	-LRB-
cord-254492-42d77vxf	231	24	Cui	Cui	NNP
cord-254492-42d77vxf	231	25	et	et	FW
cord-254492-42d77vxf	231	26	al	al	NNP
cord-254492-42d77vxf	231	27	.	.	NNP
cord-254492-42d77vxf	231	28	,	,	,
cord-254492-42d77vxf	231	29	2010	2010	CD
cord-254492-42d77vxf	231	30	;	;	:
cord-254492-42d77vxf	231	31	Kuenzel	Kuenzel	NNP
cord-254492-42d77vxf	231	32	et	et	NNP
cord-254492-42d77vxf	231	33	al	al	NNP
cord-254492-42d77vxf	231	34	.	.	NNP
cord-254492-42d77vxf	231	35	,	,	,
cord-254492-42d77vxf	231	36	2010	2010	CD
cord-254492-42d77vxf	231	37	)	)	-RRB-
cord-254492-42d77vxf	231	38	.	.	.
cord-254492-42d77vxf	232	1	Given	give	VBN
cord-254492-42d77vxf	232	2	the	the	DT
cord-254492-42d77vxf	232	3	diversity	diversity	NN
cord-254492-42d77vxf	232	4	of	of	IN
cord-254492-42d77vxf	232	5	interactions	interaction	NNS
cord-254492-42d77vxf	232	6	that	that	WDT
cord-254492-42d77vxf	232	7	NLRC5	NLRC5	NNP
cord-254492-42d77vxf	232	8	takes	take	VBZ
cord-254492-42d77vxf	232	9	part	part	NN
cord-254492-42d77vxf	232	10	in	in	RP
cord-254492-42d77vxf	232	11	,	,	,
cord-254492-42d77vxf	232	12	it	-PRON-	PRP
cord-254492-42d77vxf	232	13	is	be	VBZ
cord-254492-42d77vxf	232	14	likely	likely	JJ
cord-254492-42d77vxf	232	15	that	that	IN
cord-254492-42d77vxf	232	16	further	further	JJ
cord-254492-42d77vxf	232	17	PTMs	ptm	NNS
cord-254492-42d77vxf	232	18	will	will	MD
cord-254492-42d77vxf	232	19	be	be	VB
cord-254492-42d77vxf	232	20	shown	show	VBN
cord-254492-42d77vxf	232	21	to	to	TO
cord-254492-42d77vxf	232	22	regulate	regulate	VB
cord-254492-42d77vxf	232	23	NLRC5	nlrc5	RB
cord-254492-42d77vxf	232	24	during	during	IN
cord-254492-42d77vxf	232	25	viral	viral	JJ
cord-254492-42d77vxf	232	26	infection	infection	NN
cord-254492-42d77vxf	232	27	.	.	.
cord-254492-42d77vxf	233	1	NLRP4	NLRP4	NNP
cord-254492-42d77vxf	233	2	has	have	VBZ
cord-254492-42d77vxf	233	3	gained	gain	VBN
cord-254492-42d77vxf	233	4	prominence	prominence	NN
cord-254492-42d77vxf	233	5	as	as	IN
cord-254492-42d77vxf	233	6	another	another	DT
cord-254492-42d77vxf	233	7	negative	negative	JJ
cord-254492-42d77vxf	233	8	regulator	regulator	NN
cord-254492-42d77vxf	233	9	of	of	IN
cord-254492-42d77vxf	233	10	multiple	multiple	JJ
cord-254492-42d77vxf	233	11	immune	immune	NN
cord-254492-42d77vxf	233	12	signaling	signal	VBG
cord-254492-42d77vxf	233	13	pathways	pathway	NNS
cord-254492-42d77vxf	233	14	that	that	WDT
cord-254492-42d77vxf	233	15	is	be	VBZ
cord-254492-42d77vxf	233	16	more	more	RBR
cord-254492-42d77vxf	233	17	widely	widely	RB
cord-254492-42d77vxf	233	18	expressed	express	VBN
cord-254492-42d77vxf	233	19	than	than	IN
cord-254492-42d77vxf	233	20	NLRC5	nlrc5	NN
cord-254492-42d77vxf	233	21	.	.	.
cord-254492-42d77vxf	234	1	NLRP4	NLRP4	NNP
cord-254492-42d77vxf	234	2	was	be	VBD
cord-254492-42d77vxf	234	3	initially	initially	RB
cord-254492-42d77vxf	234	4	described	describe	VBN
cord-254492-42d77vxf	234	5	to	to	TO
cord-254492-42d77vxf	234	6	inhibit	inhibit	VB
cord-254492-42d77vxf	234	7	IKKα	IKKα	NNS
cord-254492-42d77vxf	234	8	-	-	HYPH
cord-254492-42d77vxf	234	9	mediated	mediate	VBN
cord-254492-42d77vxf	234	10	NF	nf	NN
cord-254492-42d77vxf	234	11	-	-	HYPH
cord-254492-42d77vxf	234	12	κB	κb	CD
cord-254492-42d77vxf	234	13	activation	activation	NN
cord-254492-42d77vxf	234	14	(	(	-LRB-
cord-254492-42d77vxf	234	15	Fiorentino	Fiorentino	NNP
cord-254492-42d77vxf	234	16	et	et	FW
cord-254492-42d77vxf	234	17	al	al	NNP
cord-254492-42d77vxf	234	18	.	.	NNP
cord-254492-42d77vxf	234	19	,	,	,
cord-254492-42d77vxf	234	20	2002	2002	CD
cord-254492-42d77vxf	234	21	)	)	-RRB-
cord-254492-42d77vxf	234	22	.	.	.
cord-254492-42d77vxf	235	1	Upon	upon	IN
cord-254492-42d77vxf	235	2	RLR	RLR	NNP
cord-254492-42d77vxf	235	3	cascade	cascade	NN
cord-254492-42d77vxf	235	4	activation	activation	NN
cord-254492-42d77vxf	235	5	,	,	,
cord-254492-42d77vxf	235	6	NLRP4	NLRP4	NNP
cord-254492-42d77vxf	235	7	also	also	RB
cord-254492-42d77vxf	235	8	inhibits	inhibit	VBZ
cord-254492-42d77vxf	235	9	IRF3	IRF3	NNP
cord-254492-42d77vxf	235	10	activation	activation	NN
cord-254492-42d77vxf	235	11	by	by	IN
cord-254492-42d77vxf	235	12	recruiting	recruit	VBG
cord-254492-42d77vxf	235	13	the	the	DT
cord-254492-42d77vxf	235	14	E3	E3	NNP
cord-254492-42d77vxf	235	15	deltex-4	deltex-4	NNP
cord-254492-42d77vxf	235	16	(	(	-LRB-
cord-254492-42d77vxf	235	17	DTX4	DTX4	NNP
cord-254492-42d77vxf	235	18	)	)	-RRB-
cord-254492-42d77vxf	235	19	to	to	IN
cord-254492-42d77vxf	235	20	ubiquitinate	ubiquitinate	VB
cord-254492-42d77vxf	235	21	and	and	CC
cord-254492-42d77vxf	235	22	degrade	degrade	VB
cord-254492-42d77vxf	235	23	TBK1	TBK1	NNP
cord-254492-42d77vxf	235	24	(	(	-LRB-
cord-254492-42d77vxf	235	25	Cui	Cui	NNP
cord-254492-42d77vxf	235	26	et	et	FW
cord-254492-42d77vxf	235	27	al	al	NNP
cord-254492-42d77vxf	235	28	.	.	NNP
cord-254492-42d77vxf	235	29	,	,	,
cord-254492-42d77vxf	235	30	2012	2012	CD
cord-254492-42d77vxf	235	31	)	)	-RRB-
cord-254492-42d77vxf	235	32	,	,	,
cord-254492-42d77vxf	235	33	revealing	reveal	VBG
cord-254492-42d77vxf	235	34	yet	yet	RB
cord-254492-42d77vxf	235	35	another	another	DT
cord-254492-42d77vxf	235	36	route	route	NN
cord-254492-42d77vxf	235	37	for	for	IN
cord-254492-42d77vxf	235	38	RLR	RLR	NNP
cord-254492-42d77vxf	235	39	/	/	SYM
cord-254492-42d77vxf	235	40	NLR	NLR	NNP
cord-254492-42d77vxf	235	41	cross	cross	NN
cord-254492-42d77vxf	235	42	-	-	NN
cord-254492-42d77vxf	235	43	talk	talk	NN
cord-254492-42d77vxf	236	1	(	(	-LRB-
cord-254492-42d77vxf	236	2	Fig	Fig	NNP
cord-254492-42d77vxf	236	3	.	.	NNP
cord-254492-42d77vxf	236	4	2	2	CD
cord-254492-42d77vxf	236	5	,	,	,
cord-254492-42d77vxf	236	6	right	right	RB
cord-254492-42d77vxf	236	7	)	)	-RRB-
cord-254492-42d77vxf	236	8	.	.	.
cord-254492-42d77vxf	237	1	TLRs	tlr	NNS
cord-254492-42d77vxf	237	2	are	be	VBP
cord-254492-42d77vxf	237	3	differentially	differentially	RB
cord-254492-42d77vxf	237	4	expressed	express	VBN
cord-254492-42d77vxf	237	5	in	in	IN
cord-254492-42d77vxf	237	6	a	a	DT
cord-254492-42d77vxf	237	7	wide	wide	JJ
cord-254492-42d77vxf	237	8	range	range	NN
cord-254492-42d77vxf	237	9	of	of	IN
cord-254492-42d77vxf	237	10	cell	cell	NN
cord-254492-42d77vxf	237	11	populations	population	NNS
cord-254492-42d77vxf	237	12	.	.	.
cord-254492-42d77vxf	238	1	TLR3	TLR3	NNP
cord-254492-42d77vxf	238	2	,	,	,
cord-254492-42d77vxf	238	3	TLR7	TLR7	NNP
cord-254492-42d77vxf	238	4	,	,	,
cord-254492-42d77vxf	238	5	TLR8	TLR8	NNP
cord-254492-42d77vxf	238	6	,	,	,
cord-254492-42d77vxf	238	7	and	and	CC
cord-254492-42d77vxf	238	8	TLR9	TLR9	NNP
cord-254492-42d77vxf	238	9	are	be	VBP
cord-254492-42d77vxf	238	10	expressed	express	VBN
cord-254492-42d77vxf	238	11	in	in	IN
cord-254492-42d77vxf	238	12	endosomal	endosomal	NNP
cord-254492-42d77vxf	238	13	vesicles	vesicle	NNS
cord-254492-42d77vxf	238	14	,	,	,
cord-254492-42d77vxf	238	15	whereas	whereas	IN
cord-254492-42d77vxf	238	16	TLR2	TLR2	NNP
cord-254492-42d77vxf	238	17	and	and	CC
cord-254492-42d77vxf	238	18	TLR4	TLR4	NNP
cord-254492-42d77vxf	238	19	are	be	VBP
cord-254492-42d77vxf	238	20	expressed	express	VBN
cord-254492-42d77vxf	238	21	on	on	IN
cord-254492-42d77vxf	238	22	the	the	DT
cord-254492-42d77vxf	238	23	cell	cell	NN
cord-254492-42d77vxf	238	24	surface	surface	NN
cord-254492-42d77vxf	238	25	.	.	.
cord-254492-42d77vxf	239	1	TLR3	TLR3	NNP
cord-254492-42d77vxf	239	2	recognizes	recognize	VBZ
cord-254492-42d77vxf	239	3	double	double	RB
cord-254492-42d77vxf	239	4	-	-	HYPH
cord-254492-42d77vxf	239	5	stranded	strand	VBN
cord-254492-42d77vxf	239	6	RNA	RNA	NNP
cord-254492-42d77vxf	239	7	,	,	,
cord-254492-42d77vxf	239	8	activating	activate	VBG
cord-254492-42d77vxf	239	9	NF	nf	NN
cord-254492-42d77vxf	239	10	-	-	HYPH
cord-254492-42d77vxf	239	11	κB	κB	NNP
cord-254492-42d77vxf	239	12	-	-	HYPH
cord-254492-42d77vxf	239	13	mediated	mediate	VBN
cord-254492-42d77vxf	239	14	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	239	15	cytokine	cytokine	NN
cord-254492-42d77vxf	239	16	production	production	NN
cord-254492-42d77vxf	239	17	and	and	CC
cord-254492-42d77vxf	239	18	strongly	strongly	RB
cord-254492-42d77vxf	239	19	up	up	RB
cord-254492-42d77vxf	239	20	-	-	HYPH
cord-254492-42d77vxf	239	21	regulating	regulate	VBG
cord-254492-42d77vxf	239	22	TBK1/	TBK1/	NNP
cord-254492-42d77vxf	240	1	IRF3-dependent	IRF3-dependent	NNP
cord-254492-42d77vxf	240	2	IFN	IFN	NNP
cord-254492-42d77vxf	240	3	-	-	HYPH
cord-254492-42d77vxf	240	4	I	-PRON-	PRP
cord-254492-42d77vxf	240	5	expression	expression	NN
cord-254492-42d77vxf	240	6	.	.	.
cord-254492-42d77vxf	241	1	TLR7	TLR7	NNP
cord-254492-42d77vxf	241	2	and	and	CC
cord-254492-42d77vxf	241	3	TLR8	TLR8	NNP
cord-254492-42d77vxf	241	4	recognize	recognize	VB
cord-254492-42d77vxf	241	5	ssRNA	ssrna	NN
cord-254492-42d77vxf	241	6	,	,	,
cord-254492-42d77vxf	241	7	up	up	RB
cord-254492-42d77vxf	241	8	-	-	HYPH
cord-254492-42d77vxf	241	9	regulating	regulate	VBG
cord-254492-42d77vxf	241	10	IFN	IFN	NNP
cord-254492-42d77vxf	241	11	-	-	HYPH
cord-254492-42d77vxf	241	12	α	α	NN
cord-254492-42d77vxf	241	13	and	and	CC
cord-254492-42d77vxf	241	14	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	241	15	cytokine	cytokine	NN
cord-254492-42d77vxf	241	16	production	production	NN
cord-254492-42d77vxf	241	17	.	.	.
cord-254492-42d77vxf	242	1	TLR9	TLR9	NNP
cord-254492-42d77vxf	242	2	recognizes	recognize	VBZ
cord-254492-42d77vxf	242	3	unmethylated	unmethylate	VBN
cord-254492-42d77vxf	242	4	cytosine	cytosine	NN
cord-254492-42d77vxf	242	5	-	-	HYPH
cord-254492-42d77vxf	242	6	phosphate	phosphate	NN
cord-254492-42d77vxf	242	7	-	-	HYPH
cord-254492-42d77vxf	242	8	guanine	guanine	NN
cord-254492-42d77vxf	242	9	(	(	-LRB-
cord-254492-42d77vxf	242	10	CpG	CpG	NNP
cord-254492-42d77vxf	242	11	)	)	-RRB-
cord-254492-42d77vxf	242	12	DNA	DNA	NNP
cord-254492-42d77vxf	242	13	,	,	,
cord-254492-42d77vxf	242	14	a	a	DT
cord-254492-42d77vxf	242	15	common	common	JJ
cord-254492-42d77vxf	242	16	feature	feature	NN
cord-254492-42d77vxf	242	17	of	of	IN
cord-254492-42d77vxf	242	18	nonmammalian	nonmammalian	JJ
cord-254492-42d77vxf	242	19	genomes	genome	NNS
cord-254492-42d77vxf	242	20	,	,	,
cord-254492-42d77vxf	242	21	and	and	CC
cord-254492-42d77vxf	242	22	stimulates	stimulate	VBZ
cord-254492-42d77vxf	242	23	IFN	IFN	NNP
cord-254492-42d77vxf	242	24	-	-	HYPH
cord-254492-42d77vxf	242	25	α	α	NN
cord-254492-42d77vxf	242	26	production	production	NN
cord-254492-42d77vxf	242	27	.	.	.
cord-254492-42d77vxf	243	1	TLR2	TLR2	NNP
cord-254492-42d77vxf	243	2	and	and	CC
cord-254492-42d77vxf	243	3	TLR4	TLR4	NNP
cord-254492-42d77vxf	243	4	are	be	VBP
cord-254492-42d77vxf	243	5	activated	activate	VBN
cord-254492-42d77vxf	243	6	by	by	IN
cord-254492-42d77vxf	243	7	a	a	DT
cord-254492-42d77vxf	243	8	variety	variety	NN
cord-254492-42d77vxf	243	9	of	of	IN
cord-254492-42d77vxf	243	10	microbial	microbial	JJ
cord-254492-42d77vxf	243	11	ligands	ligand	NNS
cord-254492-42d77vxf	243	12	,	,	,
cord-254492-42d77vxf	243	13	including	include	VBG
cord-254492-42d77vxf	243	14	specific	specific	JJ
cord-254492-42d77vxf	243	15	viral	viral	JJ
cord-254492-42d77vxf	243	16	proteins	protein	NNS
cord-254492-42d77vxf	243	17	,	,	,
cord-254492-42d77vxf	243	18	resulting	result	VBG
cord-254492-42d77vxf	243	19	in	in	IN
cord-254492-42d77vxf	243	20	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	243	21	cytokine	cytokine	NN
cord-254492-42d77vxf	243	22	expression	expression	NN
cord-254492-42d77vxf	243	23	(	(	-LRB-
cord-254492-42d77vxf	243	24	Fig	Fig	NNP
cord-254492-42d77vxf	243	25	.	.	NNP
cord-254492-42d77vxf	243	26	2	2	CD
cord-254492-42d77vxf	243	27	,	,	,
cord-254492-42d77vxf	243	28	left	leave	VBN
cord-254492-42d77vxf	243	29	)	)	-RRB-
cord-254492-42d77vxf	243	30	.	.	.
cord-254492-42d77vxf	244	1	NF	NF	NNP
cord-254492-42d77vxf	244	2	-	-	HYPH
cord-254492-42d77vxf	244	3	κB	κb	CD
cord-254492-42d77vxf	244	4	activation	activation	NN
cord-254492-42d77vxf	244	5	and	and	CC
cord-254492-42d77vxf	244	6	IFN	IFN	NNP
cord-254492-42d77vxf	244	7	-	-	HYPH
cord-254492-42d77vxf	244	8	I	-PRON-	PRP
cord-254492-42d77vxf	244	9	up	up	IN
cord-254492-42d77vxf	244	10	-	-	HYPH
cord-254492-42d77vxf	244	11	regulation	regulation	NN
cord-254492-42d77vxf	244	12	.	.	.
cord-254492-42d77vxf	245	1	TLR2	TLR2	NNP
cord-254492-42d77vxf	245	2	,	,	,
cord-254492-42d77vxf	245	3	TLR4	TLR4	NNP
cord-254492-42d77vxf	245	4	,	,	,
cord-254492-42d77vxf	245	5	TLR7	TLR7	NNP
cord-254492-42d77vxf	245	6	,	,	,
cord-254492-42d77vxf	245	7	TLR8	TLR8	NNP
cord-254492-42d77vxf	245	8	,	,	,
cord-254492-42d77vxf	245	9	and	and	CC
cord-254492-42d77vxf	245	10	TLR9	TLR9	NNP
cord-254492-42d77vxf	245	11	signaling	signaling	NN
cord-254492-42d77vxf	245	12	is	be	VBZ
cord-254492-42d77vxf	245	13	mediated	mediate	VBN
cord-254492-42d77vxf	245	14	through	through	IN
cord-254492-42d77vxf	245	15	the	the	DT
cord-254492-42d77vxf	245	16	adaptor	adaptor	NN
cord-254492-42d77vxf	245	17	protein	protein	NN
cord-254492-42d77vxf	245	18	myeloid	myeloid	NN
cord-254492-42d77vxf	245	19	differentiation	differentiation	NN
cord-254492-42d77vxf	245	20	primary	primary	JJ
cord-254492-42d77vxf	245	21	response	response	NN
cord-254492-42d77vxf	245	22	gene	gene	NN
cord-254492-42d77vxf	245	23	88	88	CD
cord-254492-42d77vxf	245	24	(	(	-LRB-
cord-254492-42d77vxf	245	25	MyD88	MyD88	NNS
cord-254492-42d77vxf	245	26	;	;	:
cord-254492-42d77vxf	245	27	Fig	Fig	NNP
cord-254492-42d77vxf	245	28	.	.	NNP
cord-254492-42d77vxf	245	29	2	2	CD
cord-254492-42d77vxf	245	30	,	,	,
cord-254492-42d77vxf	245	31	left	leave	VBN
cord-254492-42d77vxf	245	32	)	)	-RRB-
cord-254492-42d77vxf	245	33	.	.	.
cord-254492-42d77vxf	246	1	MyD88	MyD88	NNS
cord-254492-42d77vxf	246	2	recruits	recruit	VBZ
cord-254492-42d77vxf	246	3	NF	nf	NN
cord-254492-42d77vxf	246	4	-	-	HYPH
cord-254492-42d77vxf	246	5	κB	κB	NNP
cord-254492-42d77vxf	246	6	and	and	CC
cord-254492-42d77vxf	246	7	IFN-	IFN-	NNP
cord-254492-42d77vxf	247	1	I	-PRON-	PRP
cord-254492-42d77vxf	247	2	signaling	signal	VBG
cord-254492-42d77vxf	247	3	components	component	NNS
cord-254492-42d77vxf	247	4	,	,	,
cord-254492-42d77vxf	247	5	including	include	VBG
cord-254492-42d77vxf	247	6	interleukin-1	interleukin-1	NNP
cord-254492-42d77vxf	247	7	receptor	receptor	NN
cord-254492-42d77vxf	247	8	-	-	HYPH
cord-254492-42d77vxf	247	9	associated	associate	VBN
cord-254492-42d77vxf	247	10	kinase	kinase	NN
cord-254492-42d77vxf	247	11	1	1	CD
cord-254492-42d77vxf	247	12	(	(	-LRB-
cord-254492-42d77vxf	247	13	IRAK1	IRAK1	NNP
cord-254492-42d77vxf	247	14	)	)	-RRB-
cord-254492-42d77vxf	247	15	,	,	,
cord-254492-42d77vxf	247	16	IRAK4	IRAK4	NNP
cord-254492-42d77vxf	247	17	,	,	,
cord-254492-42d77vxf	247	18	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	247	19	,	,	,
cord-254492-42d77vxf	247	20	and	and	CC
cord-254492-42d77vxf	247	21	IRF7	IRF7	NNP
cord-254492-42d77vxf	247	22	.	.	.
cord-254492-42d77vxf	248	1	Activated	activate	VBN
cord-254492-42d77vxf	248	2	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	248	3	ubiquitinates	ubiquitinates	NNP
cord-254492-42d77vxf	248	4	IRF7	IRF7	NNP
cord-254492-42d77vxf	248	5	,	,	,
cord-254492-42d77vxf	248	6	leading	lead	VBG
cord-254492-42d77vxf	248	7	to	to	IN
cord-254492-42d77vxf	248	8	IFN	IFN	NNP
cord-254492-42d77vxf	248	9	-	-	HYPH
cord-254492-42d77vxf	248	10	α	α	NNP
cord-254492-42d77vxf	248	11	expression	expression	NN
cord-254492-42d77vxf	249	1	(	(	-LRB-
cord-254492-42d77vxf	249	2	Kawai	Kawai	NNP
cord-254492-42d77vxf	249	3	et	et	NNP
cord-254492-42d77vxf	249	4	al	al	NNP
cord-254492-42d77vxf	249	5	.	.	NNP
cord-254492-42d77vxf	249	6	,	,	,
cord-254492-42d77vxf	249	7	2004	2004	CD
cord-254492-42d77vxf	249	8	)	)	-RRB-
cord-254492-42d77vxf	249	9	.	.	.
cord-254492-42d77vxf	250	1	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	250	2	also	also	RB
cord-254492-42d77vxf	250	3	promotes	promote	VBZ
cord-254492-42d77vxf	250	4	K63linked	K63linked	NNP
cord-254492-42d77vxf	250	5	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	250	6	of	of	IN
cord-254492-42d77vxf	250	7	NEMO	NEMO	NNP
cord-254492-42d77vxf	250	8	,	,	,
cord-254492-42d77vxf	250	9	enabling	enable	VBG
cord-254492-42d77vxf	250	10	recruitment	recruitment	NN
cord-254492-42d77vxf	250	11	of	of	IN
cord-254492-42d77vxf	250	12	the	the	DT
cord-254492-42d77vxf	250	13	TGF	TGF	NNP
cord-254492-42d77vxf	250	14	-	-	HYPH
cord-254492-42d77vxf	250	15	β	β	NN
cord-254492-42d77vxf	250	16	-	-	HYPH
cord-254492-42d77vxf	250	17	activated	activate	VBN
cord-254492-42d77vxf	250	18	kinase	kinase	NN
cord-254492-42d77vxf	250	19	(	(	-LRB-
cord-254492-42d77vxf	250	20	TAB)-TAK1	tab)-tak1	JJ
cord-254492-42d77vxf	250	21	kinase	kinase	NN
cord-254492-42d77vxf	250	22	complex	complex	JJ
cord-254492-42d77vxf	250	23	(	(	-LRB-
cord-254492-42d77vxf	250	24	Tseng	Tseng	NNP
cord-254492-42d77vxf	250	25	et	et	NNP
cord-254492-42d77vxf	250	26	al	al	NNP
cord-254492-42d77vxf	250	27	.	.	NNP
cord-254492-42d77vxf	250	28	,	,	,
cord-254492-42d77vxf	250	29	2010	2010	CD
cord-254492-42d77vxf	250	30	)	)	-RRB-
cord-254492-42d77vxf	250	31	.	.	.
cord-254492-42d77vxf	251	1	Subsequent	subsequent	JJ
cord-254492-42d77vxf	251	2	association	association	NN
cord-254492-42d77vxf	251	3	between	between	IN
cord-254492-42d77vxf	251	4	NEMO	NEMO	NNP
cord-254492-42d77vxf	251	5	and	and	CC
cord-254492-42d77vxf	251	6	M1-polyubiquitin	M1-polyubiquitin	NNPS
cord-254492-42d77vxf	251	7	chains	chain	NNS
cord-254492-42d77vxf	251	8	induces	induce	VBZ
cord-254492-42d77vxf	251	9	TAK1-mediated	tak1-mediated	JJ
cord-254492-42d77vxf	251	10	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	251	11	of	of	IN
cord-254492-42d77vxf	251	12	IKKα	IKKα	NNS
cord-254492-42d77vxf	251	13	and	and	CC
cord-254492-42d77vxf	251	14	IKKβ	IKKβ	NNP
cord-254492-42d77vxf	251	15	,	,	,
cord-254492-42d77vxf	251	16	priming	prime	VBG
cord-254492-42d77vxf	251	17	them	-PRON-	PRP
cord-254492-42d77vxf	251	18	for	for	IN
cord-254492-42d77vxf	251	19	full	full	JJ
cord-254492-42d77vxf	251	20	transactivation	transactivation	NN
cord-254492-42d77vxf	251	21	through	through	IN
cord-254492-42d77vxf	251	22	autophosphorylation	autophosphorylation	NN
cord-254492-42d77vxf	251	23	.	.	.
cord-254492-42d77vxf	252	1	Activated	activate	VBN
cord-254492-42d77vxf	252	2	IKKα	IKKα	NNP
cord-254492-42d77vxf	252	3	phosphorylates	phosphorylate	VBZ
cord-254492-42d77vxf	252	4	the	the	DT
cord-254492-42d77vxf	252	5	IκBα	IκBα	NNP
cord-254492-42d77vxf	252	6	subunit	subunit	NN
cord-254492-42d77vxf	252	7	,	,	,
cord-254492-42d77vxf	252	8	leading	lead	VBG
cord-254492-42d77vxf	252	9	to	to	IN
cord-254492-42d77vxf	252	10	its	-PRON-	PRP$
cord-254492-42d77vxf	252	11	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	252	12	and	and	CC
cord-254492-42d77vxf	252	13	proteasomal	proteasomal	JJ
cord-254492-42d77vxf	252	14	degradation	degradation	NN
cord-254492-42d77vxf	252	15	and	and	CC
cord-254492-42d77vxf	252	16	releasing	release	VBG
cord-254492-42d77vxf	252	17	NF	nf	NN
cord-254492-42d77vxf	252	18	-	-	HYPH
cord-254492-42d77vxf	252	19	κB	κB	NNP
cord-254492-42d77vxf	252	20	for	for	IN
cord-254492-42d77vxf	252	21	nuclear	nuclear	JJ
cord-254492-42d77vxf	252	22	translocation	translocation	NN
cord-254492-42d77vxf	252	23	.	.	.
cord-254492-42d77vxf	253	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	253	2	,	,	,
cord-254492-42d77vxf	253	3	MyD88	MyD88	NNPS
cord-254492-42d77vxf	253	4	,	,	,
cord-254492-42d77vxf	253	5	IRAK1/4	IRAK1/4	NNP
cord-254492-42d77vxf	253	6	,	,	,
cord-254492-42d77vxf	253	7	and	and	CC
cord-254492-42d77vxf	253	8	TAB2/3	TAB2/3	NNP
cord-254492-42d77vxf	253	9	are	be	VBP
cord-254492-42d77vxf	253	10	also	also	RB
cord-254492-42d77vxf	253	11	modified	modify	VBN
cord-254492-42d77vxf	253	12	and	and	CC
cord-254492-42d77vxf	253	13	activated	activate	VBN
cord-254492-42d77vxf	253	14	by	by	IN
cord-254492-42d77vxf	253	15	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	253	16	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	253	17	chains	chain	NNS
cord-254492-42d77vxf	253	18	.	.	.
cord-254492-42d77vxf	254	1	Such	such	JJ
cord-254492-42d77vxf	254	2	chains	chain	NNS
cord-254492-42d77vxf	254	3	were	be	VBD
cord-254492-42d77vxf	254	4	recently	recently	RB
cord-254492-42d77vxf	254	5	described	describe	VBN
cord-254492-42d77vxf	254	6	as	as	IN
cord-254492-42d77vxf	254	7	substrates	substrate	NNS
cord-254492-42d77vxf	254	8	for	for	IN
cord-254492-42d77vxf	254	9	M1-polyubiquitination	m1-polyubiquitination	NN
cord-254492-42d77vxf	254	10	by	by	IN
cord-254492-42d77vxf	254	11	HOIP	HOIP	NNP
cord-254492-42d77vxf	254	12	,	,	,
cord-254492-42d77vxf	254	13	resulting	result	VBG
cord-254492-42d77vxf	254	14	in	in	IN
cord-254492-42d77vxf	254	15	hybrid	hybrid	JJ
cord-254492-42d77vxf	254	16	chains	chain	NNS
cord-254492-42d77vxf	254	17	that	that	WDT
cord-254492-42d77vxf	254	18	may	may	MD
cord-254492-42d77vxf	254	19	connect	connect	VB
cord-254492-42d77vxf	254	20	the	the	DT
cord-254492-42d77vxf	254	21	MyD88/	MyD88/	NNP
cord-254492-42d77vxf	254	22	IRAK	IRAK	NNP
cord-254492-42d77vxf	254	23	and	and	CC
cord-254492-42d77vxf	254	24	TAK1	TAK1	NNP
cord-254492-42d77vxf	254	25	/	/	SYM
cord-254492-42d77vxf	254	26	IKK	IKK	NNP
cord-254492-42d77vxf	254	27	signaling	signal	VBG
cord-254492-42d77vxf	254	28	apparatus	apparatus	NN
cord-254492-42d77vxf	254	29	(	(	-LRB-
cord-254492-42d77vxf	254	30	Emmerich	Emmerich	NNP
cord-254492-42d77vxf	254	31	et	et	NNP
cord-254492-42d77vxf	254	32	al	al	NNP
cord-254492-42d77vxf	254	33	.	.	NNP
cord-254492-42d77vxf	254	34	,	,	,
cord-254492-42d77vxf	254	35	2013	2013	CD
cord-254492-42d77vxf	254	36	)	)	-RRB-
cord-254492-42d77vxf	254	37	.	.	.
cord-254492-42d77vxf	255	1	TLR3	TLR3	NNP
cord-254492-42d77vxf	255	2	signaling	signaling	NN
cord-254492-42d77vxf	255	3	is	be	VBZ
cord-254492-42d77vxf	255	4	mediated	mediate	VBN
cord-254492-42d77vxf	255	5	by	by	IN
cord-254492-42d77vxf	255	6	TIR	TIR	NNP
cord-254492-42d77vxf	255	7	domain	domain	NN
cord-254492-42d77vxf	255	8	-	-	HYPH
cord-254492-42d77vxf	255	9	containing	contain	VBG
cord-254492-42d77vxf	255	10	adaptor	adaptor	NN
cord-254492-42d77vxf	255	11	-	-	HYPH
cord-254492-42d77vxf	255	12	inducing	induce	VBG
cord-254492-42d77vxf	255	13	IFN	IFN	NNP
cord-254492-42d77vxf	255	14	-	-	HYPH
cord-254492-42d77vxf	255	15	β	β	NNP
cord-254492-42d77vxf	255	16	(	(	-LRB-
cord-254492-42d77vxf	255	17	TRIF	TRIF	NNP
cord-254492-42d77vxf	255	18	)	)	-RRB-
cord-254492-42d77vxf	255	19	.	.	.
cord-254492-42d77vxf	256	1	TRIF	TRIF	NNP
cord-254492-42d77vxf	256	2	activates	activate	VBZ
cord-254492-42d77vxf	256	3	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	256	4	,	,	,
cord-254492-42d77vxf	256	5	which	which	WDT
cord-254492-42d77vxf	256	6	promotes	promote	VBZ
cord-254492-42d77vxf	256	7	IRF3	IRF3	NNP
cord-254492-42d77vxf	256	8	/	/	SYM
cord-254492-42d77vxf	256	9	IRF7	IRF7	NNP
cord-254492-42d77vxf	256	10	activation	activation	NN
cord-254492-42d77vxf	256	11	(	(	-LRB-
cord-254492-42d77vxf	257	1	Tseng	Tseng	NNP
cord-254492-42d77vxf	257	2	et	et	NNP
cord-254492-42d77vxf	257	3	al	al	NNP
cord-254492-42d77vxf	257	4	.	.	NNP
cord-254492-42d77vxf	257	5	,	,	,
cord-254492-42d77vxf	257	6	2010	2010	CD
cord-254492-42d77vxf	257	7	)	)	-RRB-
cord-254492-42d77vxf	257	8	,	,	,
cord-254492-42d77vxf	257	9	and	and	CC
cord-254492-42d77vxf	257	10	also	also	RB
cord-254492-42d77vxf	257	11	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	257	12	,	,	,
cord-254492-42d77vxf	257	13	which	which	WDT
cord-254492-42d77vxf	257	14	promotes	promote	VBZ
cord-254492-42d77vxf	257	15	IKK	IKK	NNP
cord-254492-42d77vxf	257	16	activation	activation	NN
cord-254492-42d77vxf	257	17	(	(	-LRB-
cord-254492-42d77vxf	257	18	Fig	Fig	NNP
cord-254492-42d77vxf	257	19	.	.	NNP
cord-254492-42d77vxf	257	20	2	2	CD
cord-254492-42d77vxf	257	21	,	,	,
cord-254492-42d77vxf	257	22	left	leave	VBN
cord-254492-42d77vxf	257	23	;	;	.
cord-254492-42d77vxf	258	1	Jiang	Jiang	NNP
cord-254492-42d77vxf	258	2	et	et	NNP
cord-254492-42d77vxf	258	3	al	al	NNP
cord-254492-42d77vxf	258	4	.	.	NNP
cord-254492-42d77vxf	258	5	,	,	,
cord-254492-42d77vxf	258	6	2004	2004	CD
cord-254492-42d77vxf	258	7	)	)	-RRB-
cord-254492-42d77vxf	258	8	.	.	.
cord-254492-42d77vxf	259	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	259	2	regulates	regulate	VBZ
cord-254492-42d77vxf	259	3	the	the	DT
cord-254492-42d77vxf	259	4	MyD88-and	myd88-and	JJ
cord-254492-42d77vxf	259	5	TRIF	trif	NN
cord-254492-42d77vxf	259	6	-	-	HYPH
cord-254492-42d77vxf	259	7	dependent	dependent	JJ
cord-254492-42d77vxf	259	8	pathways	pathway	NNS
cord-254492-42d77vxf	259	9	.	.	.
cord-254492-42d77vxf	260	1	Although	although	IN
cord-254492-42d77vxf	260	2	TLRs	tlr	NNS
cord-254492-42d77vxf	260	3	undergo	undergo	VBP
cord-254492-42d77vxf	260	4	extensive	extensive	JJ
cord-254492-42d77vxf	260	5	PTM	PTM	NNP
cord-254492-42d77vxf	260	6	,	,	,
cord-254492-42d77vxf	260	7	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	260	8	performs	perform	VBZ
cord-254492-42d77vxf	260	9	no	no	DT
cord-254492-42d77vxf	260	10	known	know	VBN
cord-254492-42d77vxf	260	11	role	role	NN
cord-254492-42d77vxf	260	12	in	in	IN
cord-254492-42d77vxf	260	13	regulating	regulate	VBG
cord-254492-42d77vxf	260	14	TLRs	tlr	NNS
cord-254492-42d77vxf	260	15	directly	directly	RB
cord-254492-42d77vxf	260	16	.	.	.
cord-254492-42d77vxf	261	1	Instead	instead	RB
cord-254492-42d77vxf	261	2	,	,	,
cord-254492-42d77vxf	261	3	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	261	4	modulates	modulate	VBZ
cord-254492-42d77vxf	261	5	their	-PRON-	PRP$
cord-254492-42d77vxf	261	6	downstream	downstream	JJ
cord-254492-42d77vxf	261	7	signaling	signal	VBG
cord-254492-42d77vxf	261	8	targets	target	NNS
cord-254492-42d77vxf	261	9	,	,	,
cord-254492-42d77vxf	261	10	particularly	particularly	RB
cord-254492-42d77vxf	261	11	MyD88	MyD88	NNS
cord-254492-42d77vxf	261	12	,	,	,
cord-254492-42d77vxf	261	13	TRIF	TRIF	NNP
cord-254492-42d77vxf	261	14	,	,	,
cord-254492-42d77vxf	261	15	and	and	CC
cord-254492-42d77vxf	261	16	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	261	17	,	,	,
cord-254492-42d77vxf	261	18	and	and	CC
cord-254492-42d77vxf	261	19	it	-PRON-	PRP
cord-254492-42d77vxf	261	20	is	be	VBZ
cord-254492-42d77vxf	261	21	often	often	RB
cord-254492-42d77vxf	261	22	here	here	RB
cord-254492-42d77vxf	261	23	that	that	IN
cord-254492-42d77vxf	261	24	viruses	virus	NNS
cord-254492-42d77vxf	261	25	terminate	terminate	VBP
cord-254492-42d77vxf	261	26	TLR	TLR	NNP
cord-254492-42d77vxf	261	27	-	-	HYPH
cord-254492-42d77vxf	261	28	mediated	mediate	VBN
cord-254492-42d77vxf	261	29	immunity	immunity	NN
cord-254492-42d77vxf	261	30	.	.	.
cord-254492-42d77vxf	262	1	Nrdp1	Nrdp1	NNP
cord-254492-42d77vxf	262	2	is	be	VBZ
cord-254492-42d77vxf	262	3	an	an	DT
cord-254492-42d77vxf	262	4	E3	e3	NN
cord-254492-42d77vxf	262	5	that	that	WDT
cord-254492-42d77vxf	262	6	promotes	promote	VBZ
cord-254492-42d77vxf	262	7	IFN	IFN	NNP
cord-254492-42d77vxf	262	8	-	-	HYPH
cord-254492-42d77vxf	262	9	I	-PRON-	PRP
cord-254492-42d77vxf	262	10	expression	expression	NN
cord-254492-42d77vxf	262	11	at	at	IN
cord-254492-42d77vxf	262	12	the	the	DT
cord-254492-42d77vxf	262	13	expense	expense	NN
cord-254492-42d77vxf	262	14	of	of	IN
cord-254492-42d77vxf	262	15	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	262	16	cytokines	cytokine	NNS
cord-254492-42d77vxf	262	17	.	.	.
cord-254492-42d77vxf	263	1	TBK1	tbk1	CD
cord-254492-42d77vxf	263	2	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	263	3	by	by	IN
cord-254492-42d77vxf	263	4	Nrdp1	Nrdp1	NNP
cord-254492-42d77vxf	263	5	activates	activate	VBZ
cord-254492-42d77vxf	263	6	TBK1	TBK1	NNP
cord-254492-42d77vxf	263	7	in	in	IN
cord-254492-42d77vxf	263	8	TRIF	TRIF	NNP
cord-254492-42d77vxf	263	9	-	-	HYPH
cord-254492-42d77vxf	263	10	mediated	mediate	VBN
cord-254492-42d77vxf	263	11	IFN	IFN	NNP
cord-254492-42d77vxf	263	12	-	-	HYPH
cord-254492-42d77vxf	263	13	I	-PRON-	PRP
cord-254492-42d77vxf	263	14	expression	expression	NN
cord-254492-42d77vxf	263	15	,	,	,
cord-254492-42d77vxf	263	16	which	which	WDT
cord-254492-42d77vxf	263	17	simultaneously	simultaneously	RB
cord-254492-42d77vxf	263	18	K48-polyubiquitinates	K48-polyubiquitinates	NNP
cord-254492-42d77vxf	263	19	and	and	CC
cord-254492-42d77vxf	263	20	down	down	RB
cord-254492-42d77vxf	263	21	-	-	HYPH
cord-254492-42d77vxf	263	22	regulates	regulate	NNS
cord-254492-42d77vxf	263	23	MyD88-mediated	myd88-mediated	JJ
cord-254492-42d77vxf	263	24	NF	NF	NNP
cord-254492-42d77vxf	263	25	-	-	HYPH
cord-254492-42d77vxf	263	26	κB	κb	CD
cord-254492-42d77vxf	263	27	activation	activation	NN
cord-254492-42d77vxf	263	28	.	.	.
cord-254492-42d77vxf	264	1	Conversely	conversely	RB
cord-254492-42d77vxf	264	2	,	,	,
cord-254492-42d77vxf	264	3	the	the	DT
cord-254492-42d77vxf	264	4	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	264	5	-	-	HYPH
cord-254492-42d77vxf	264	6	editing	editing	NN
cord-254492-42d77vxf	264	7	enzyme	enzyme	NN
cord-254492-42d77vxf	264	8	A20	A20	NNP
cord-254492-42d77vxf	264	9	inhibits	inhibit	VBZ
cord-254492-42d77vxf	264	10	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	264	11	-	-	HYPH
cord-254492-42d77vxf	264	12	mediated	mediate	VBN
cord-254492-42d77vxf	264	13	activation	activation	NN
cord-254492-42d77vxf	264	14	of	of	IN
cord-254492-42d77vxf	264	15	TRAF6	traf6	NN
cord-254492-42d77vxf	264	16	,	,	,
cord-254492-42d77vxf	264	17	inhibiting	inhibit	VBG
cord-254492-42d77vxf	264	18	NF	nf	NN
cord-254492-42d77vxf	264	19	-	-	HYPH
cord-254492-42d77vxf	264	20	κB	κb	CD
cord-254492-42d77vxf	264	21	activation	activation	NN
cord-254492-42d77vxf	264	22	via	via	IN
cord-254492-42d77vxf	264	23	the	the	DT
cord-254492-42d77vxf	264	24	TLR	TLR	NNP
cord-254492-42d77vxf	264	25	and	and	CC
cord-254492-42d77vxf	264	26	NLR	NLR	NNP
cord-254492-42d77vxf	264	27	cascades	cascade	NNS
cord-254492-42d77vxf	264	28	,	,	,
cord-254492-42d77vxf	264	29	as	as	RB
cord-254492-42d77vxf	264	30	well	well	RB
cord-254492-42d77vxf	264	31	as	as	IN
cord-254492-42d77vxf	264	32	TBK1	TBK1	NNP
cord-254492-42d77vxf	264	33	,	,	,
cord-254492-42d77vxf	264	34	inhibiting	inhibit	VBG
cord-254492-42d77vxf	264	35	IFN	IFN	NNP
cord-254492-42d77vxf	264	36	-	-	HYPH
cord-254492-42d77vxf	264	37	I	-PRON-	PRP
cord-254492-42d77vxf	264	38	expression	expression	NN
cord-254492-42d77vxf	264	39	Turer	Turer	NNP
cord-254492-42d77vxf	264	40	et	et	NNP
cord-254492-42d77vxf	264	41	al	al	NNP
cord-254492-42d77vxf	264	42	.	.	.
cord-254492-42d77vxf	265	1	,	,	,
cord-254492-42d77vxf	265	2	2008	2008	CD
cord-254492-42d77vxf	265	3	;	;	:
cord-254492-42d77vxf	265	4	Parvatiyar	Parvatiyar	NNP
cord-254492-42d77vxf	265	5	et	et	NNP
cord-254492-42d77vxf	265	6	al	al	NNP
cord-254492-42d77vxf	265	7	.	.	NNP
cord-254492-42d77vxf	265	8	,	,	,
cord-254492-42d77vxf	265	9	2010	2010	CD
cord-254492-42d77vxf	265	10	)	)	-RRB-
cord-254492-42d77vxf	265	11	.	.	.
cord-254492-42d77vxf	266	1	Additional	additional	JJ
cord-254492-42d77vxf	266	2	avenues	avenue	NNS
cord-254492-42d77vxf	266	3	of	of	IN
cord-254492-42d77vxf	266	4	signaling	signal	VBG
cord-254492-42d77vxf	266	5	cross	cross	NN
cord-254492-42d77vxf	266	6	-	-	NN
cord-254492-42d77vxf	266	7	talk	talk	NN
cord-254492-42d77vxf	266	8	include	include	VBP
cord-254492-42d77vxf	266	9	Smurf1	Smurf1	NNP
cord-254492-42d77vxf	266	10	and	and	CC
cord-254492-42d77vxf	266	11	Smurf2	Smurf2	NNP
cord-254492-42d77vxf	266	12	,	,	,
cord-254492-42d77vxf	266	13	which	which	WDT
cord-254492-42d77vxf	266	14	degrade	degrade	VBP
cord-254492-42d77vxf	266	15	MAVS	MAVS	NNP
cord-254492-42d77vxf	266	16	and	and	CC
cord-254492-42d77vxf	266	17	inhibit	inhibit	VB
cord-254492-42d77vxf	266	18	IFN	IFN	NNP
cord-254492-42d77vxf	266	19	-	-	HYPH
cord-254492-42d77vxf	266	20	I	I	NNP
cord-254492-42d77vxf	266	21	activation	activation	NN
cord-254492-42d77vxf	266	22	.	.	.
cord-254492-42d77vxf	267	1	Smurf1	Smurf1	NNP
cord-254492-42d77vxf	267	2	and	and	CC
cord-254492-42d77vxf	267	3	Smurf2	Smurf2	NNP
cord-254492-42d77vxf	267	4	also	also	RB
cord-254492-42d77vxf	267	5	degrade	degrade	VBP
cord-254492-42d77vxf	267	6	MyD88	MyD88	NNS
cord-254492-42d77vxf	267	7	,	,	,
cord-254492-42d77vxf	267	8	inhibiting	inhibit	VBG
cord-254492-42d77vxf	267	9	TLR	tlr	NN
cord-254492-42d77vxf	267	10	-	-	HYPH
cord-254492-42d77vxf	267	11	mediated	mediate	VBN
cord-254492-42d77vxf	267	12	NF	nf	NN
cord-254492-42d77vxf	267	13	-	-	HYPH
cord-254492-42d77vxf	267	14	κB	κb	CD
cord-254492-42d77vxf	267	15	activation	activation	NN
cord-254492-42d77vxf	267	16	(	(	-LRB-
cord-254492-42d77vxf	267	17	Lee	Lee	NNP
cord-254492-42d77vxf	267	18	et	et	NNP
cord-254492-42d77vxf	267	19	al	al	NNP
cord-254492-42d77vxf	267	20	.	.	NNP
cord-254492-42d77vxf	267	21	,	,	,
cord-254492-42d77vxf	267	22	2011	2011	CD
cord-254492-42d77vxf	267	23	)	)	-RRB-
cord-254492-42d77vxf	267	24	.	.	.
cord-254492-42d77vxf	268	1	cIAP2	cIAP2	NNP
cord-254492-42d77vxf	268	2	is	be	VBZ
cord-254492-42d77vxf	268	3	an	an	DT
cord-254492-42d77vxf	268	4	E3	e3	NN
cord-254492-42d77vxf	268	5	that	that	IN
cord-254492-42d77vxf	268	6	,	,	,
cord-254492-42d77vxf	268	7	after	after	IN
cord-254492-42d77vxf	268	8	itself	-PRON-	PRP
cord-254492-42d77vxf	268	9	being	be	VBG
cord-254492-42d77vxf	268	10	ubiquitinated	ubiquitinate	VBN
cord-254492-42d77vxf	268	11	by	by	IN
cord-254492-42d77vxf	268	12	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	268	13	,	,	,
cord-254492-42d77vxf	268	14	targets	target	VBZ
cord-254492-42d77vxf	268	15	TRAF3	traf3	NN
cord-254492-42d77vxf	268	16	for	for	IN
cord-254492-42d77vxf	268	17	degradation	degradation	NN
cord-254492-42d77vxf	269	1	(	(	-LRB-
cord-254492-42d77vxf	269	2	Tseng	Tseng	NNP
cord-254492-42d77vxf	269	3	et	et	NNP
cord-254492-42d77vxf	269	4	al	al	NNP
cord-254492-42d77vxf	269	5	.	.	NNP
cord-254492-42d77vxf	269	6	,	,	,
cord-254492-42d77vxf	269	7	2010	2010	CD
cord-254492-42d77vxf	269	8	)	)	-RRB-
cord-254492-42d77vxf	269	9	.	.	.
cord-254492-42d77vxf	270	1	This	this	DT
cord-254492-42d77vxf	270	2	is	be	VBZ
cord-254492-42d77vxf	270	3	important	important	JJ
cord-254492-42d77vxf	270	4	in	in	IN
cord-254492-42d77vxf	270	5	promoting	promote	VBG
cord-254492-42d77vxf	270	6	TLR4-mediated	tlr4-mediated	JJ
cord-254492-42d77vxf	270	7	signaling	signal	VBG
cord-254492-42d77vxf	270	8	and	and	CC
cord-254492-42d77vxf	270	9	cytokine	cytokine	NN
cord-254492-42d77vxf	270	10	production	production	NN
cord-254492-42d77vxf	270	11	at	at	IN
cord-254492-42d77vxf	270	12	the	the	DT
cord-254492-42d77vxf	270	13	expense	expense	NN
cord-254492-42d77vxf	270	14	of	of	IN
cord-254492-42d77vxf	270	15	type	type	NN
cord-254492-42d77vxf	271	1	I	-PRON-	PRP
cord-254492-42d77vxf	271	2	IFN	IFN	NNP
cord-254492-42d77vxf	271	3	production	production	NN
cord-254492-42d77vxf	271	4	.	.	.
cord-254492-42d77vxf	272	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	272	2	,	,	,
cord-254492-42d77vxf	272	3	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	272	4	itself	-PRON-	PRP
cord-254492-42d77vxf	272	5	promotes	promote	VBZ
cord-254492-42d77vxf	272	6	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	272	7	cytokine	cytokine	NN
cord-254492-42d77vxf	272	8	production	production	NN
cord-254492-42d77vxf	272	9	at	at	IN
cord-254492-42d77vxf	272	10	the	the	DT
cord-254492-42d77vxf	272	11	expense	expense	NN
cord-254492-42d77vxf	272	12	of	of	IN
cord-254492-42d77vxf	272	13	IFN	IFN	NNP
cord-254492-42d77vxf	272	14	-	-	HYPH
cord-254492-42d77vxf	272	15	I.	I.	NNP
cord-254492-42d77vxf	272	16	TRAF6	traf6	NN
cord-254492-42d77vxf	272	17	is	be	VBZ
cord-254492-42d77vxf	272	18	activated	activate	VBN
cord-254492-42d77vxf	272	19	by	by	IN
cord-254492-42d77vxf	272	20	trans	trans	NNP
cord-254492-42d77vxf	272	21	-	-	NN
cord-254492-42d77vxf	272	22	autoubiquitination	autoubiquitination	NN
cord-254492-42d77vxf	272	23	at	at	IN
cord-254492-42d77vxf	272	24	K124	k124	CD
cord-254492-42d77vxf	272	25	,	,	,
cord-254492-42d77vxf	272	26	abolition	abolition	NN
cord-254492-42d77vxf	272	27	of	of	IN
cord-254492-42d77vxf	272	28	which	which	WDT
cord-254492-42d77vxf	272	29	eliminates	eliminate	VBZ
cord-254492-42d77vxf	272	30	NEMO	nemo	NN
cord-254492-42d77vxf	272	31	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	272	32	and	and	CC
cord-254492-42d77vxf	272	33	TAK1	TAK1	NNP
cord-254492-42d77vxf	272	34	activation	activation	NN
cord-254492-42d77vxf	273	1	(	(	-LRB-
cord-254492-42d77vxf	273	2	Lamothe	Lamothe	NNP
cord-254492-42d77vxf	273	3	et	et	FW
cord-254492-42d77vxf	273	4	al	al	NNP
cord-254492-42d77vxf	273	5	.	.	NNP
cord-254492-42d77vxf	273	6	,	,	,
cord-254492-42d77vxf	273	7	2007	2007	CD
cord-254492-42d77vxf	273	8	)	)	-RRB-
cord-254492-42d77vxf	273	9	.	.	.
cord-254492-42d77vxf	274	1	This	this	DT
cord-254492-42d77vxf	274	2	mechanism	mechanism	NN
cord-254492-42d77vxf	274	3	is	be	VBZ
cord-254492-42d77vxf	274	4	exploited	exploit	VBN
cord-254492-42d77vxf	274	5	by	by	IN
cord-254492-42d77vxf	274	6	HSV	HSV	NNP
cord-254492-42d77vxf	274	7	,	,	,
cord-254492-42d77vxf	274	8	which	which	WDT
cord-254492-42d77vxf	274	9	uses	use	VBZ
cord-254492-42d77vxf	274	10	the	the	DT
cord-254492-42d77vxf	274	11	virally	virally	RB
cord-254492-42d77vxf	274	12	encoded	encode	VBN
cord-254492-42d77vxf	274	13	E3	E3	NNP
cord-254492-42d77vxf	274	14	infected	infected	JJ
cord-254492-42d77vxf	274	15	cell	cell	NN
cord-254492-42d77vxf	274	16	polypeptide	polypeptide	NN
cord-254492-42d77vxf	274	17	0	0	CD
cord-254492-42d77vxf	275	1	(	(	-LRB-
cord-254492-42d77vxf	275	2	ICP0	ICP0	NNP
cord-254492-42d77vxf	275	3	)	)	-RRB-
cord-254492-42d77vxf	275	4	to	to	TO
cord-254492-42d77vxf	275	5	recruit	recruit	VB
cord-254492-42d77vxf	275	6	USP7	USP7	NNP
cord-254492-42d77vxf	275	7	to	to	TO
cord-254492-42d77vxf	275	8	deubiquitinate	deubiquitinate	VB
cord-254492-42d77vxf	275	9	NEMO	NEMO	NNP
cord-254492-42d77vxf	275	10	and	and	CC
cord-254492-42d77vxf	275	11	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	275	12	(	(	-LRB-
cord-254492-42d77vxf	275	13	Daubeuf	Daubeuf	NNP
cord-254492-42d77vxf	275	14	et	et	NNP
cord-254492-42d77vxf	275	15	al	al	NNP
cord-254492-42d77vxf	275	16	.	.	NNP
cord-254492-42d77vxf	275	17	,	,	,
cord-254492-42d77vxf	275	18	2009	2009	CD
cord-254492-42d77vxf	275	19	)	)	-RRB-
cord-254492-42d77vxf	275	20	.	.	.
cord-254492-42d77vxf	276	1	In	in	IN
cord-254492-42d77vxf	276	2	addition	addition	NN
cord-254492-42d77vxf	276	3	,	,	,
cord-254492-42d77vxf	276	4	ICP0	ICP0	NNP
cord-254492-42d77vxf	276	5	directly	directly	RB
cord-254492-42d77vxf	276	6	catalyzes	catalyze	VBZ
cord-254492-42d77vxf	276	7	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	276	8	and	and	CC
cord-254492-42d77vxf	276	9	degradation	degradation	NN
cord-254492-42d77vxf	276	10	of	of	IN
cord-254492-42d77vxf	276	11	MyD88	MyD88	NNP
cord-254492-42d77vxf	276	12	and	and	CC
cord-254492-42d77vxf	276	13	TIR	TIR	NNP
cord-254492-42d77vxf	276	14	AP	AP	NNP
cord-254492-42d77vxf	277	1	(	(	-LRB-
cord-254492-42d77vxf	277	2	Toll	toll	NN
cord-254492-42d77vxf	277	3	/	/	SYM
cord-254492-42d77vxf	277	4	interleukin-1	interleukin-1	NN
cord-254492-42d77vxf	277	5	receptor	receptor	NN
cord-254492-42d77vxf	277	6	domain	domain	NN
cord-254492-42d77vxf	277	7	-	-	HYPH
cord-254492-42d77vxf	277	8	containing	contain	VBG
cord-254492-42d77vxf	277	9	adaptor	adaptor	NN
cord-254492-42d77vxf	277	10	protein	protein	NN
cord-254492-42d77vxf	277	11	;	;	:
cord-254492-42d77vxf	277	12	van	van	NNP
cord-254492-42d77vxf	277	13	Lint	Lint	NNP
cord-254492-42d77vxf	277	14	et	et	NNP
cord-254492-42d77vxf	277	15	al	al	NNP
cord-254492-42d77vxf	277	16	.	.	NNP
cord-254492-42d77vxf	277	17	,	,	,
cord-254492-42d77vxf	277	18	2010	2010	CD
cord-254492-42d77vxf	277	19	)	)	-RRB-
cord-254492-42d77vxf	277	20	.	.	.
cord-254492-42d77vxf	278	1	Kaposi	Kaposi	NNP
cord-254492-42d77vxf	278	2	's	's	POS
cord-254492-42d77vxf	278	3	sarcoma	sarcoma	NN
cord-254492-42d77vxf	278	4	-	-	HYPH
cord-254492-42d77vxf	278	5	associated	associate	VBN
cord-254492-42d77vxf	278	6	herpesvirus	herpesvirus	NN
cord-254492-42d77vxf	278	7	(	(	-LRB-
cord-254492-42d77vxf	278	8	KSHV	KSHV	NNP
cord-254492-42d77vxf	278	9	)	)	-RRB-
cord-254492-42d77vxf	278	10	encodes	encode	VBZ
cord-254492-42d77vxf	278	11	replication	replication	NN
cord-254492-42d77vxf	278	12	and	and	CC
cord-254492-42d77vxf	278	13	transcription	transcription	NN
cord-254492-42d77vxf	278	14	factor	factor	NN
cord-254492-42d77vxf	278	15	(	(	-LRB-
cord-254492-42d77vxf	278	16	RTA	RTA	NNP
cord-254492-42d77vxf	278	17	)	)	-RRB-
cord-254492-42d77vxf	278	18	,	,	,
cord-254492-42d77vxf	278	19	an	an	DT
cord-254492-42d77vxf	278	20	E3	e3	NN
cord-254492-42d77vxf	278	21	that	that	WDT
cord-254492-42d77vxf	278	22	activates	activate	VBZ
cord-254492-42d77vxf	278	23	latent	latent	JJ
cord-254492-42d77vxf	278	24	virus	virus	NN
cord-254492-42d77vxf	278	25	.	.	.
cord-254492-42d77vxf	279	1	This	this	DT
cord-254492-42d77vxf	279	2	activation	activation	NN
cord-254492-42d77vxf	279	3	process	process	NN
cord-254492-42d77vxf	279	4	involves	involve	VBZ
cord-254492-42d77vxf	279	5	suppression	suppression	NN
cord-254492-42d77vxf	279	6	of	of	IN
cord-254492-42d77vxf	279	7	antiviral	antiviral	JJ
cord-254492-42d77vxf	279	8	cytokines	cytokine	NNS
cord-254492-42d77vxf	279	9	,	,	,
cord-254492-42d77vxf	279	10	partly	partly	RB
cord-254492-42d77vxf	279	11	involving	involve	VBG
cord-254492-42d77vxf	279	12	RTA	RTA	NNP
cord-254492-42d77vxf	279	13	-	-	HYPH
cord-254492-42d77vxf	279	14	catalyzed	catalyze	VBN
cord-254492-42d77vxf	279	15	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	279	16	and	and	CC
cord-254492-42d77vxf	279	17	degradation	degradation	NN
cord-254492-42d77vxf	279	18	of	of	IN
cord-254492-42d77vxf	279	19	MyD88	MyD88	NNS
cord-254492-42d77vxf	279	20	and	and	CC
cord-254492-42d77vxf	279	21	TRIF	TRIF	NNP
cord-254492-42d77vxf	280	1	(	(	-LRB-
cord-254492-42d77vxf	280	2	Ahmad	Ahmad	NNP
cord-254492-42d77vxf	280	3	et	et	NNP
cord-254492-42d77vxf	280	4	al	al	NNP
cord-254492-42d77vxf	280	5	.	.	NNP
cord-254492-42d77vxf	280	6	,	,	,
cord-254492-42d77vxf	280	7	2011	2011	CD
cord-254492-42d77vxf	281	1	;	;	:
cord-254492-42d77vxf	281	2	Zhao	Zhao	NNP
cord-254492-42d77vxf	281	3	et	et	NNP
cord-254492-42d77vxf	281	4	al	al	NNP
cord-254492-42d77vxf	281	5	.	.	NNP
cord-254492-42d77vxf	281	6	,	,	,
cord-254492-42d77vxf	281	7	2015	2015	CD
cord-254492-42d77vxf	281	8	)	)	-RRB-
cord-254492-42d77vxf	281	9	,	,	,
cord-254492-42d77vxf	281	10	thereby	thereby	RB
cord-254492-42d77vxf	281	11	impairing	impair	VBG
cord-254492-42d77vxf	281	12	all	all	DT
cord-254492-42d77vxf	281	13	TLR	tlr	NN
cord-254492-42d77vxf	281	14	-	-	HYPH
cord-254492-42d77vxf	281	15	mediated	mediate	VBN
cord-254492-42d77vxf	281	16	immune	immune	NN
cord-254492-42d77vxf	281	17	signaling	signal	VBG
cord-254492-42d77vxf	281	18	pathways	pathway	NNS
cord-254492-42d77vxf	281	19	.	.	.
cord-254492-42d77vxf	282	1	The	the	DT
cord-254492-42d77vxf	282	2	final	final	JJ
cord-254492-42d77vxf	282	3	relay	relay	NN
cord-254492-42d77vxf	282	4	:	:	:
cord-254492-42d77vxf	282	5	IRFs	irfs	NN
cord-254492-42d77vxf	282	6	transmit	transmit	VB
cord-254492-42d77vxf	282	7	danger	danger	NN
cord-254492-42d77vxf	282	8	signals	signal	NNS
cord-254492-42d77vxf	282	9	into	into	IN
cord-254492-42d77vxf	282	10	the	the	DT
cord-254492-42d77vxf	282	11	nucleus	nucleus	NN
cord-254492-42d77vxf	282	12	TLR	TLR	NNP
cord-254492-42d77vxf	282	13	,	,	,
cord-254492-42d77vxf	282	14	NLR	NLR	NNP
cord-254492-42d77vxf	282	15	,	,	,
cord-254492-42d77vxf	282	16	and	and	CC
cord-254492-42d77vxf	282	17	RLR	RLR	NNP
cord-254492-42d77vxf	282	18	IFN-	IFN-	NNP
cord-254492-42d77vxf	283	1	I	-PRON-	PRP
cord-254492-42d77vxf	283	2	signaling	signal	VBG
cord-254492-42d77vxf	283	3	converges	converge	VBZ
cord-254492-42d77vxf	283	4	at	at	IN
cord-254492-42d77vxf	283	5	IRF	IRF	NNP
cord-254492-42d77vxf	283	6	activation	activation	NN
cord-254492-42d77vxf	283	7	,	,	,
cord-254492-42d77vxf	283	8	the	the	DT
cord-254492-42d77vxf	283	9	penultimate	penultimate	JJ
cord-254492-42d77vxf	283	10	step	step	NN
cord-254492-42d77vxf	283	11	toward	toward	IN
cord-254492-42d77vxf	283	12	IFN	IFN	NNP
cord-254492-42d77vxf	283	13	-	-	HYPH
cord-254492-42d77vxf	283	14	I	-PRON-	PRP
cord-254492-42d77vxf	283	15	transcription	transcription	NN
cord-254492-42d77vxf	283	16	.	.	.
cord-254492-42d77vxf	284	1	IRF3	IRF3	NNP
cord-254492-42d77vxf	284	2	is	be	VBZ
cord-254492-42d77vxf	284	3	constitutively	constitutively	RB
cord-254492-42d77vxf	284	4	expressed	express	VBN
cord-254492-42d77vxf	284	5	in	in	IN
cord-254492-42d77vxf	284	6	most	most	JJS
cord-254492-42d77vxf	284	7	cell	cell	NN
cord-254492-42d77vxf	284	8	types	type	NNS
cord-254492-42d77vxf	284	9	,	,	,
cord-254492-42d77vxf	284	10	residing	reside	VBG
cord-254492-42d77vxf	284	11	inactive	inactive	JJ
cord-254492-42d77vxf	284	12	in	in	IN
cord-254492-42d77vxf	284	13	the	the	DT
cord-254492-42d77vxf	284	14	cytosol	cytosol	NN
cord-254492-42d77vxf	284	15	until	until	IN
cord-254492-42d77vxf	284	16	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	284	17	by	by	IN
cord-254492-42d77vxf	284	18	TBK1	TBK1	NNP
cord-254492-42d77vxf	284	19	/	/	SYM
cord-254492-42d77vxf	284	20	IKKε	IKKε	NNS
cord-254492-42d77vxf	284	21	within	within	IN
cord-254492-42d77vxf	284	22	two	two	CD
cord-254492-42d77vxf	284	23	activation	activation	NN
cord-254492-42d77vxf	284	24	clusters	cluster	NNS
cord-254492-42d77vxf	284	25	(	(	-LRB-
cord-254492-42d77vxf	284	26	Ser385	Ser385	NNP
cord-254492-42d77vxf	284	27	/	/	SYM
cord-254492-42d77vxf	284	28	Ser386	ser386	CD
cord-254492-42d77vxf	284	29	and	and	CC
cord-254492-42d77vxf	284	30	Ser396/	Ser396/	NNP
cord-254492-42d77vxf	284	31	Ser398/	Ser398/	.
cord-254492-42d77vxf	285	1	Ser402/	Ser402/	.
cord-254492-42d77vxf	286	1	Thr404	Thr404	NNP
cord-254492-42d77vxf	286	2	/	/	SYM
cord-254492-42d77vxf	286	3	Ser405	ser405	CD
cord-254492-42d77vxf	286	4	)	)	-RRB-
cord-254492-42d77vxf	286	5	,	,	,
cord-254492-42d77vxf	286	6	resulting	result	VBG
cord-254492-42d77vxf	286	7	in	in	IN
cord-254492-42d77vxf	286	8	homodimerization	homodimerization	NN
cord-254492-42d77vxf	286	9	,	,	,
cord-254492-42d77vxf	286	10	nuclear	nuclear	JJ
cord-254492-42d77vxf	286	11	accumulation	accumulation	NN
cord-254492-42d77vxf	286	12	,	,	,
cord-254492-42d77vxf	286	13	DNA	dna	NN
cord-254492-42d77vxf	286	14	binding	binding	NN
cord-254492-42d77vxf	286	15	,	,	,
cord-254492-42d77vxf	286	16	and	and	CC
cord-254492-42d77vxf	286	17	participation	participation	NN
cord-254492-42d77vxf	286	18	in	in	IN
cord-254492-42d77vxf	286	19	IFNB	IFNB	NNP
cord-254492-42d77vxf	286	20	gene	gene	NN
cord-254492-42d77vxf	286	21	transcription	transcription	NN
cord-254492-42d77vxf	286	22	(	(	-LRB-
cord-254492-42d77vxf	286	23	Lin	Lin	NNP
cord-254492-42d77vxf	286	24	et	et	NNP
cord-254492-42d77vxf	286	25	al	al	NNP
cord-254492-42d77vxf	286	26	.	.	NNP
cord-254492-42d77vxf	286	27	,	,	,
cord-254492-42d77vxf	286	28	1998	1998	CD
cord-254492-42d77vxf	286	29	)	)	-RRB-
cord-254492-42d77vxf	286	30	.	.	.
cord-254492-42d77vxf	287	1	IFN	IFN	NNP
cord-254492-42d77vxf	287	2	-	-	HYPH
cord-254492-42d77vxf	287	3	β	β	NNP
cord-254492-42d77vxf	287	4	acts	act	VBZ
cord-254492-42d77vxf	287	5	in	in	IN
cord-254492-42d77vxf	287	6	an	an	DT
cord-254492-42d77vxf	287	7	autocrine	autocrine	JJ
cord-254492-42d77vxf	287	8	and	and	CC
cord-254492-42d77vxf	287	9	paracrine	paracrine	JJ
cord-254492-42d77vxf	287	10	manner	manner	NN
cord-254492-42d77vxf	287	11	upon	upon	IN
cord-254492-42d77vxf	287	12	its	-PRON-	PRP$
cord-254492-42d77vxf	287	13	cognate	cognate	JJ
cord-254492-42d77vxf	287	14	receptor	receptor	NN
cord-254492-42d77vxf	287	15	,	,	,
cord-254492-42d77vxf	287	16	IFN	IFN	NNP
cord-254492-42d77vxf	287	17	-	-	HYPH
cord-254492-42d77vxf	287	18	α	α	NNP
cord-254492-42d77vxf	287	19	/	/	SYM
cord-254492-42d77vxf	287	20	β	β	NN
cord-254492-42d77vxf	287	21	receptor	receptor	NN
cord-254492-42d77vxf	287	22	(	(	-LRB-
cord-254492-42d77vxf	287	23	IFN	IFN	NNP
cord-254492-42d77vxf	287	24	AR	AR	NNP
cord-254492-42d77vxf	287	25	)	)	-RRB-
cord-254492-42d77vxf	287	26	,	,	,
cord-254492-42d77vxf	287	27	thereby	thereby	RB
cord-254492-42d77vxf	287	28	activating	activate	VBG
cord-254492-42d77vxf	287	29	JAK	JAK	NNP
cord-254492-42d77vxf	287	30	/	/	SYM
cord-254492-42d77vxf	287	31	STAT	stat	NN
cord-254492-42d77vxf	287	32	signaling	signal	VBG
cord-254492-42d77vxf	287	33	and	and	CC
cord-254492-42d77vxf	287	34	ISG	ISG	NNP
cord-254492-42d77vxf	287	35	expression	expression	NN
cord-254492-42d77vxf	287	36	.	.	.
cord-254492-42d77vxf	288	1	IRF7	irf7	JJ
cord-254492-42d77vxf	288	2	expression	expression	NN
cord-254492-42d77vxf	288	3	is	be	VBZ
cord-254492-42d77vxf	288	4	up	up	RB
cord-254492-42d77vxf	288	5	-	-	HYPH
cord-254492-42d77vxf	288	6	regulated	regulate	VBN
cord-254492-42d77vxf	288	7	in	in	IN
cord-254492-42d77vxf	288	8	this	this	DT
cord-254492-42d77vxf	288	9	way	way	NN
cord-254492-42d77vxf	288	10	,	,	,
cord-254492-42d77vxf	288	11	which	which	WDT
cord-254492-42d77vxf	288	12	in	in	IN
cord-254492-42d77vxf	288	13	turn	turn	NN
cord-254492-42d77vxf	288	14	activates	activate	VBZ
cord-254492-42d77vxf	288	15	IFNA	IFNA	NNP
cord-254492-42d77vxf	288	16	transcription	transcription	NN
cord-254492-42d77vxf	288	17	and	and	CC
cord-254492-42d77vxf	288	18	additional	additional	JJ
cord-254492-42d77vxf	288	19	ISG	ISG	NNP
cord-254492-42d77vxf	288	20	expression	expression	NN
cord-254492-42d77vxf	288	21	by	by	IN
cord-254492-42d77vxf	288	22	a	a	DT
cord-254492-42d77vxf	288	23	similar	similar	JJ
cord-254492-42d77vxf	288	24	mechanism	mechanism	NN
cord-254492-42d77vxf	288	25	.	.	.
cord-254492-42d77vxf	289	1	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	289	2	is	be	VBZ
cord-254492-42d77vxf	289	3	an	an	DT
cord-254492-42d77vxf	289	4	IRF	IRF	NNP
cord-254492-42d77vxf	289	5	master	master	NN
cord-254492-42d77vxf	289	6	toggle	toggle	NN
cord-254492-42d77vxf	289	7	.	.	.
cord-254492-42d77vxf	290	1	The	the	DT
cord-254492-42d77vxf	290	2	IRFs	irf	NNS
cord-254492-42d77vxf	290	3	are	be	VBP
cord-254492-42d77vxf	290	4	among	among	IN
cord-254492-42d77vxf	290	5	the	the	DT
cord-254492-42d77vxf	290	6	most	most	RBS
cord-254492-42d77vxf	290	7	tightly	tightly	RB
cord-254492-42d77vxf	290	8	controlled	control	VBN
cord-254492-42d77vxf	290	9	IFN	IFN	NNP
cord-254492-42d77vxf	290	10	-	-	HYPH
cord-254492-42d77vxf	290	11	I	I	NNP
cord-254492-42d77vxf	290	12	signaling	signal	VBG
cord-254492-42d77vxf	290	13	proteins	protein	NNS
cord-254492-42d77vxf	290	14	through	through	IN
cord-254492-42d77vxf	290	15	an	an	DT
cord-254492-42d77vxf	290	16	interplay	interplay	NN
cord-254492-42d77vxf	290	17	of	of	IN
cord-254492-42d77vxf	290	18	PTMs	ptm	NNS
cord-254492-42d77vxf	290	19	,	,	,
cord-254492-42d77vxf	290	20	including	include	VBG
cord-254492-42d77vxf	290	21	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	290	22	,	,	,
cord-254492-42d77vxf	290	23	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	290	24	,	,	,
cord-254492-42d77vxf	290	25	and	and	CC
cord-254492-42d77vxf	290	26	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	290	27	-	-	HYPH
cord-254492-42d77vxf	290	28	like	like	JJ
cord-254492-42d77vxf	290	29	modifications	modification	NNS
cord-254492-42d77vxf	290	30	.	.	.
cord-254492-42d77vxf	291	1	Phosphorylation	Phosphorylation	NNP
cord-254492-42d77vxf	291	2	of	of	IN
cord-254492-42d77vxf	291	3	IRF7	IRF7	NNP
cord-254492-42d77vxf	291	4	at	at	IN
cord-254492-42d77vxf	291	5	Ser477	ser477	CD
cord-254492-42d77vxf	291	6	and	and	CC
cord-254492-42d77vxf	291	7	Ser479	Ser479	NNS
cord-254492-42d77vxf	291	8	by	by	IN
cord-254492-42d77vxf	291	9	TBK1	TBK1	NNP
cord-254492-42d77vxf	291	10	/	/	SYM
cord-254492-42d77vxf	291	11	IKKε	IKKε	NNS
cord-254492-42d77vxf	291	12	is	be	VBZ
cord-254492-42d77vxf	291	13	required	require	VBN
cord-254492-42d77vxf	291	14	for	for	IN
cord-254492-42d77vxf	291	15	its	-PRON-	PRP$
cord-254492-42d77vxf	291	16	activation	activation	NN
cord-254492-42d77vxf	291	17	(	(	-LRB-
cord-254492-42d77vxf	291	18	tenOever	tenOever	NNP
cord-254492-42d77vxf	291	19	et	et	FW
cord-254492-42d77vxf	291	20	al	al	NNP
cord-254492-42d77vxf	291	21	.	.	NNP
cord-254492-42d77vxf	291	22	,	,	,
cord-254492-42d77vxf	291	23	2004	2004	CD
cord-254492-42d77vxf	291	24	)	)	-RRB-
cord-254492-42d77vxf	291	25	.	.	.
cord-254492-42d77vxf	292	1	However	however	RB
cord-254492-42d77vxf	292	2	,	,	,
cord-254492-42d77vxf	292	3	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	292	4	by	by	IN
cord-254492-42d77vxf	292	5	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	292	6	at	at	IN
cord-254492-42d77vxf	292	7	nearby	nearby	JJ
cord-254492-42d77vxf	292	8	residues	residue	NNS
cord-254492-42d77vxf	293	1	Lys444	lys444	UH
cord-254492-42d77vxf	293	2	,	,	,
cord-254492-42d77vxf	293	3	Lys446	lys446	CD
cord-254492-42d77vxf	293	4	,	,	,
cord-254492-42d77vxf	293	5	and	and	CC
cord-254492-42d77vxf	293	6	Lys452	Lys452	NNP
cord-254492-42d77vxf	293	7	appears	appear	VBZ
cord-254492-42d77vxf	293	8	to	to	TO
cord-254492-42d77vxf	293	9	be	be	VB
cord-254492-42d77vxf	293	10	a	a	DT
cord-254492-42d77vxf	293	11	prerequisite	prerequisite	NN
cord-254492-42d77vxf	293	12	to	to	IN
cord-254492-42d77vxf	293	13	this	this	DT
cord-254492-42d77vxf	293	14	and	and	CC
cord-254492-42d77vxf	293	15	serves	serve	VBZ
cord-254492-42d77vxf	293	16	as	as	IN
cord-254492-42d77vxf	293	17	a	a	DT
cord-254492-42d77vxf	293	18	link	link	NN
cord-254492-42d77vxf	293	19	between	between	IN
cord-254492-42d77vxf	293	20	the	the	DT
cord-254492-42d77vxf	293	21	NF	nf	NN
cord-254492-42d77vxf	293	22	-	-	HYPH
cord-254492-42d77vxf	293	23	κB	κB	NNP
cord-254492-42d77vxf	293	24	and	and	CC
cord-254492-42d77vxf	293	25	IFN	IFN	NNP
cord-254492-42d77vxf	293	26	-	-	HYPH
cord-254492-42d77vxf	293	27	I	-PRON-	PRP
cord-254492-42d77vxf	293	28	activation	activation	NN
cord-254492-42d77vxf	293	29	pathways	pathway	NNS
cord-254492-42d77vxf	294	1	(	(	-LRB-
cord-254492-42d77vxf	294	2	Ning	Ning	NNP
cord-254492-42d77vxf	294	3	et	et	FW
cord-254492-42d77vxf	294	4	al	al	NNP
cord-254492-42d77vxf	294	5	.	.	NNP
cord-254492-42d77vxf	294	6	,	,	,
cord-254492-42d77vxf	294	7	2008	2008	CD
cord-254492-42d77vxf	294	8	)	)	-RRB-
cord-254492-42d77vxf	294	9	.	.	.
cord-254492-42d77vxf	295	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	295	2	,	,	,
cord-254492-42d77vxf	295	3	TRIM28	trim28	NN
cord-254492-42d77vxf	295	4	binds	bind	VBZ
cord-254492-42d77vxf	295	5	active	active	JJ
cord-254492-42d77vxf	295	6	IRF7	IRF7	NNP
cord-254492-42d77vxf	295	7	and	and	CC
cord-254492-42d77vxf	295	8	ligates	ligate	VBZ
cord-254492-42d77vxf	295	9	small	small	JJ
cord-254492-42d77vxf	295	10	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	295	11	-	-	HYPH
cord-254492-42d77vxf	295	12	like	like	JJ
cord-254492-42d77vxf	295	13	modifier	modifier	NN
cord-254492-42d77vxf	295	14	(	(	-LRB-
cord-254492-42d77vxf	295	15	SUMO	SUMO	NNP
cord-254492-42d77vxf	295	16	)	)	-RRB-
cord-254492-42d77vxf	295	17	at	at	IN
cord-254492-42d77vxf	295	18	two	two	CD
cord-254492-42d77vxf	295	19	of	of	IN
cord-254492-42d77vxf	295	20	these	these	DT
cord-254492-42d77vxf	295	21	ubiquitination	ubiquitination	JJ
cord-254492-42d77vxf	295	22	sites	site	NNS
cord-254492-42d77vxf	295	23	,	,	,
cord-254492-42d77vxf	296	1	Lys444	Lys444	NNP
cord-254492-42d77vxf	296	2	and	and	CC
cord-254492-42d77vxf	296	3	Lys446	Lys446	NNP
cord-254492-42d77vxf	296	4	,	,	,
cord-254492-42d77vxf	296	5	negatively	negatively	RB
cord-254492-42d77vxf	296	6	regulating	regulate	VBG
cord-254492-42d77vxf	296	7	virus	virus	NN
cord-254492-42d77vxf	296	8	-	-	:
cord-254492-42d77vxf	296	9	triggered	trigger	VBN
cord-254492-42d77vxf	296	10	IFN	IFN	NNP
cord-254492-42d77vxf	296	11	-	-	HYPH
cord-254492-42d77vxf	296	12	α	α	NN
cord-254492-42d77vxf	296	13	production	production	NN
cord-254492-42d77vxf	297	1	(	(	-LRB-
cord-254492-42d77vxf	297	2	Liang	Liang	NNP
cord-254492-42d77vxf	297	3	et	et	NNP
cord-254492-42d77vxf	297	4	al	al	NNP
cord-254492-42d77vxf	297	5	.	.	NNP
cord-254492-42d77vxf	297	6	,	,	,
cord-254492-42d77vxf	297	7	2011	2011	CD
cord-254492-42d77vxf	297	8	)	)	-RRB-
cord-254492-42d77vxf	297	9	,	,	,
cord-254492-42d77vxf	297	10	indicating	indicate	VBG
cord-254492-42d77vxf	297	11	that	that	IN
cord-254492-42d77vxf	297	12	as	as	RB
cord-254492-42d77vxf	297	13	yet	yet	RB
cord-254492-42d77vxf	297	14	unidentified	unidentified	JJ
cord-254492-42d77vxf	297	15	DUbs	DUbs	NNP
cord-254492-42d77vxf	297	16	or	or	CC
cord-254492-42d77vxf	297	17	deSUMOylating	desumoylating	NN
cord-254492-42d77vxf	297	18	enzymes	enzyme	NNS
cord-254492-42d77vxf	297	19	participate	participate	VBP
cord-254492-42d77vxf	297	20	in	in	IN
cord-254492-42d77vxf	297	21	regulating	regulate	VBG
cord-254492-42d77vxf	297	22	IRF7	IRF7	NNP
cord-254492-42d77vxf	297	23	.	.	.
cord-254492-42d77vxf	298	1	Reminiscent	reminiscent	JJ
cord-254492-42d77vxf	298	2	of	of	IN
cord-254492-42d77vxf	298	3	IRF7	IRF7	NNP
cord-254492-42d77vxf	298	4	,	,	,
cord-254492-42d77vxf	298	5	IRF3	IRF3	NNP
cord-254492-42d77vxf	298	6	residues	residue	NNS
cord-254492-42d77vxf	299	1	Lys70	Lys70	NNP
cord-254492-42d77vxf	299	2	and	and	CC
cord-254492-42d77vxf	299	3	Lys87	Lys87	NNP
cord-254492-42d77vxf	299	4	accept	accept	VBP
cord-254492-42d77vxf	299	5	both	both	DT
cord-254492-42d77vxf	299	6	polyubiquitin	polyubiquitin	NNP
cord-254492-42d77vxf	299	7	chains	chain	NNS
cord-254492-42d77vxf	299	8	and	and	CC
cord-254492-42d77vxf	299	9	SUMO	SUMO	NNP
cord-254492-42d77vxf	299	10	,	,	,
cord-254492-42d77vxf	299	11	and	and	CC
cord-254492-42d77vxf	299	12	competition	competition	NN
cord-254492-42d77vxf	299	13	between	between	IN
cord-254492-42d77vxf	299	14	these	these	DT
cord-254492-42d77vxf	299	15	modifications	modification	NNS
cord-254492-42d77vxf	299	16	can	can	MD
cord-254492-42d77vxf	299	17	determine	determine	VB
cord-254492-42d77vxf	299	18	the	the	DT
cord-254492-42d77vxf	299	19	fate	fate	NN
cord-254492-42d77vxf	299	20	of	of	IN
cord-254492-42d77vxf	299	21	IFN	IFN	NNP
cord-254492-42d77vxf	299	22	-	-	HYPH
cord-254492-42d77vxf	299	23	I	-PRON-	PRP
cord-254492-42d77vxf	299	24	signal	signal	VBP
cord-254492-42d77vxf	299	25	transduction	transduction	NN
cord-254492-42d77vxf	299	26	.	.	.
cord-254492-42d77vxf	300	1	At	at	IN
cord-254492-42d77vxf	300	2	steady	steady	JJ
cord-254492-42d77vxf	300	3	state	state	NN
cord-254492-42d77vxf	300	4	,	,	,
cord-254492-42d77vxf	300	5	the	the	DT
cord-254492-42d77vxf	300	6	SUMO	SUMO	NNP
cord-254492-42d77vxf	300	7	-	-	HYPH
cord-254492-42d77vxf	300	8	conjugating	conjugate	VBG
cord-254492-42d77vxf	300	9	enzyme	enzyme	NN
cord-254492-42d77vxf	300	10	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	300	11	carrier	carrier	NN
cord-254492-42d77vxf	300	12	protein	protein	NN
cord-254492-42d77vxf	300	13	9	9	CD
cord-254492-42d77vxf	300	14	(	(	-LRB-
cord-254492-42d77vxf	300	15	Ubc9	Ubc9	NNP
cord-254492-42d77vxf	300	16	)	)	-RRB-
cord-254492-42d77vxf	300	17	protects	protect	VBZ
cord-254492-42d77vxf	300	18	IRF3	IRF3	NNP
cord-254492-42d77vxf	300	19	from	from	IN
cord-254492-42d77vxf	300	20	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	300	21	-	-	HYPH
cord-254492-42d77vxf	300	22	mediated	mediate	VBN
cord-254492-42d77vxf	300	23	degradation	degradation	NN
cord-254492-42d77vxf	300	24	by	by	IN
cord-254492-42d77vxf	300	25	occupying	occupy	VBG
cord-254492-42d77vxf	300	26	these	these	DT
cord-254492-42d77vxf	300	27	sites	site	NNS
cord-254492-42d77vxf	300	28	with	with	IN
cord-254492-42d77vxf	300	29	SUMO	SUMO	NNP
cord-254492-42d77vxf	300	30	.	.	.
cord-254492-42d77vxf	301	1	Alternatively	alternatively	RB
cord-254492-42d77vxf	301	2	,	,	,
cord-254492-42d77vxf	301	3	the	the	DT
cord-254492-42d77vxf	301	4	deSUMOylating	desumoylate	VBG
cord-254492-42d77vxf	301	5	enzyme	enzyme	NN
cord-254492-42d77vxf	301	6	sentrin	sentrin	NN
cord-254492-42d77vxf	301	7	-	-	HYPH
cord-254492-42d77vxf	301	8	specific	specific	JJ
cord-254492-42d77vxf	301	9	protease	protease	NN
cord-254492-42d77vxf	301	10	2	2	CD
cord-254492-42d77vxf	301	11	(	(	-LRB-
cord-254492-42d77vxf	301	12	SENP2	senp2	NN
cord-254492-42d77vxf	301	13	)	)	-RRB-
cord-254492-42d77vxf	301	14	removes	remove	VBZ
cord-254492-42d77vxf	301	15	SUMO	SUMO	NNP
cord-254492-42d77vxf	301	16	from	from	IN
cord-254492-42d77vxf	301	17	IRF3	IRF3	NNP
cord-254492-42d77vxf	301	18	,	,	,
cord-254492-42d77vxf	301	19	enabling	enable	VBG
cord-254492-42d77vxf	301	20	its	-PRON-	PRP$
cord-254492-42d77vxf	301	21	K48-linked	k48-linked	JJ
cord-254492-42d77vxf	301	22	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	301	23	(	(	-LRB-
cord-254492-42d77vxf	301	24	Ran	run	VBD
cord-254492-42d77vxf	301	25	et	et	FW
cord-254492-42d77vxf	301	26	al	al	NNP
cord-254492-42d77vxf	301	27	.	.	NNP
cord-254492-42d77vxf	301	28	,	,	,
cord-254492-42d77vxf	301	29	2011	2011	CD
cord-254492-42d77vxf	301	30	)	)	-RRB-
cord-254492-42d77vxf	301	31	.	.	.
cord-254492-42d77vxf	302	1	Subsequent	subsequent	JJ
cord-254492-42d77vxf	302	2	work	work	NN
cord-254492-42d77vxf	302	3	identified	identify	VBD
cord-254492-42d77vxf	302	4	TRIM26	TRIM26	NNP
cord-254492-42d77vxf	302	5	as	as	IN
cord-254492-42d77vxf	302	6	an	an	DT
cord-254492-42d77vxf	302	7	E3	e3	NN
cord-254492-42d77vxf	302	8	that	that	WDT
cord-254492-42d77vxf	302	9	conjugates	conjugate	VBZ
cord-254492-42d77vxf	302	10	K48-linked	K48-linked	NNP
cord-254492-42d77vxf	302	11	polyubiquitin	polyubiquitin	NNS
cord-254492-42d77vxf	302	12	chains	chain	NNS
cord-254492-42d77vxf	302	13	to	to	IN
cord-254492-42d77vxf	302	14	these	these	DT
cord-254492-42d77vxf	302	15	same	same	JJ
cord-254492-42d77vxf	302	16	sites	site	NNS
cord-254492-42d77vxf	302	17	(	(	-LRB-
cord-254492-42d77vxf	302	18	Fig	Fig	NNP
cord-254492-42d77vxf	302	19	.	.	.
cord-254492-42d77vxf	302	20	3	3	CD
cord-254492-42d77vxf	302	21	;	;	:
cord-254492-42d77vxf	302	22	Wang	Wang	NNP
cord-254492-42d77vxf	302	23	et	et	NNP
cord-254492-42d77vxf	302	24	al	al	NNP
cord-254492-42d77vxf	302	25	.	.	NNP
cord-254492-42d77vxf	302	26	,	,	,
cord-254492-42d77vxf	302	27	2015	2015	CD
cord-254492-42d77vxf	302	28	)	)	-RRB-
cord-254492-42d77vxf	302	29	,	,	,
cord-254492-42d77vxf	302	30	triggering	trigger	VBG
cord-254492-42d77vxf	302	31	degradation	degradation	NN
cord-254492-42d77vxf	302	32	of	of	IN
cord-254492-42d77vxf	302	33	the	the	DT
cord-254492-42d77vxf	302	34	active	active	JJ
cord-254492-42d77vxf	302	35	,	,	,
cord-254492-42d77vxf	302	36	nuclear	nuclear	JJ
cord-254492-42d77vxf	302	37	-	-	HYPH
cord-254492-42d77vxf	302	38	localized	localize	VBN
cord-254492-42d77vxf	302	39	form	form	NN
cord-254492-42d77vxf	302	40	of	of	IN
cord-254492-42d77vxf	302	41	IRF3	IRF3	NNP
cord-254492-42d77vxf	302	42	.	.	.
cord-254492-42d77vxf	303	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	303	2	,	,	,
cord-254492-42d77vxf	303	3	activated	activate	VBD
cord-254492-42d77vxf	303	4	IRF3	IRF3	NNP
cord-254492-42d77vxf	303	5	undergoes	undergo	VBZ
cord-254492-42d77vxf	303	6	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	303	7	at	at	IN
cord-254492-42d77vxf	303	8	Ser339	ser339	CD
cord-254492-42d77vxf	303	9	.	.	.
cord-254492-42d77vxf	304	1	This	this	DT
cord-254492-42d77vxf	304	2	promotes	promote	VBZ
cord-254492-42d77vxf	304	3	interaction	interaction	NN
cord-254492-42d77vxf	304	4	with	with	IN
cord-254492-42d77vxf	304	5	peptidyl	peptidyl	NNP
cord-254492-42d77vxf	304	6	-	-	HYPH
cord-254492-42d77vxf	304	7	prolyl	prolyl	VBN
cord-254492-42d77vxf	305	1	cis/	cis/	NNP
cord-254492-42d77vxf	305	2	trans	trans	NNP
cord-254492-42d77vxf	305	3	isomerase	isomerase	NN
cord-254492-42d77vxf	305	4	NIMA	NIMA	NNP
cord-254492-42d77vxf	305	5	-	-	:
cord-254492-42d77vxf	305	6	interacting	interact	VBG
cord-254492-42d77vxf	305	7	1	1	CD
cord-254492-42d77vxf	305	8	(	(	-LRB-
cord-254492-42d77vxf	305	9	Pin1	Pin1	NNP
cord-254492-42d77vxf	305	10	)	)	-RRB-
cord-254492-42d77vxf	305	11	,	,	,
cord-254492-42d77vxf	305	12	a	a	DT
cord-254492-42d77vxf	305	13	nuclear	nuclear	NN
cord-254492-42d77vxf	305	14	-	-	HYPH
cord-254492-42d77vxf	305	15	localized	localize	VBN
cord-254492-42d77vxf	305	16	protein	protein	NN
cord-254492-42d77vxf	305	17	that	that	WDT
cord-254492-42d77vxf	305	18	promotes	promote	VBZ
cord-254492-42d77vxf	305	19	IRF3	IRF3	NNP
cord-254492-42d77vxf	305	20	degradation	degradation	NN
cord-254492-42d77vxf	305	21	(	(	-LRB-
cord-254492-42d77vxf	305	22	Saitoh	Saitoh	NNP
cord-254492-42d77vxf	305	23	et	et	FW
cord-254492-42d77vxf	305	24	al	al	NNP
cord-254492-42d77vxf	305	25	.	.	NNP
cord-254492-42d77vxf	305	26	,	,	,
cord-254492-42d77vxf	305	27	2006	2006	CD
cord-254492-42d77vxf	305	28	)	)	-RRB-
cord-254492-42d77vxf	305	29	.	.	.
cord-254492-42d77vxf	306	1	The	the	DT
cord-254492-42d77vxf	306	2	E3	e3	NN
cord-254492-42d77vxf	306	3	recruited	recruit	VBN
cord-254492-42d77vxf	306	4	by	by	IN
cord-254492-42d77vxf	306	5	Pin1	Pin1	NNP
cord-254492-42d77vxf	306	6	for	for	IN
cord-254492-42d77vxf	306	7	this	this	DT
cord-254492-42d77vxf	306	8	purpose	purpose	NN
cord-254492-42d77vxf	306	9	is	be	VBZ
cord-254492-42d77vxf	306	10	unknown	unknown	JJ
cord-254492-42d77vxf	306	11	;	;	:
cord-254492-42d77vxf	306	12	however	however	RB
cord-254492-42d77vxf	306	13	,	,	,
cord-254492-42d77vxf	306	14	TRIM26	TRIM26	NNP
cord-254492-42d77vxf	306	15	is	be	VBZ
cord-254492-42d77vxf	306	16	also	also	RB
cord-254492-42d77vxf	306	17	localized	localize	VBN
cord-254492-42d77vxf	306	18	to	to	IN
cord-254492-42d77vxf	306	19	the	the	DT
cord-254492-42d77vxf	306	20	nucleus	nucleus	NN
cord-254492-42d77vxf	306	21	and	and	CC
cord-254492-42d77vxf	306	22	seems	seem	VBZ
cord-254492-42d77vxf	306	23	a	a	DT
cord-254492-42d77vxf	306	24	strong	strong	JJ
cord-254492-42d77vxf	306	25	candidate	candidate	NN
cord-254492-42d77vxf	306	26	.	.	.
cord-254492-42d77vxf	307	1	IRF3	irf3	JJ
cord-254492-42d77vxf	307	2	degradation	degradation	NN
cord-254492-42d77vxf	307	3	is	be	VBZ
cord-254492-42d77vxf	307	4	undesirable	undesirable	JJ
cord-254492-42d77vxf	307	5	at	at	IN
cord-254492-42d77vxf	307	6	early	early	JJ
cord-254492-42d77vxf	307	7	stages	stage	NNS
cord-254492-42d77vxf	307	8	of	of	IN
cord-254492-42d77vxf	307	9	the	the	DT
cord-254492-42d77vxf	307	10	innate	innate	JJ
cord-254492-42d77vxf	307	11	immune	immune	JJ
cord-254492-42d77vxf	307	12	response	response	NN
cord-254492-42d77vxf	307	13	and	and	CC
cord-254492-42d77vxf	307	14	is	be	VBZ
cord-254492-42d77vxf	307	15	limited	limit	VBN
cord-254492-42d77vxf	307	16	in	in	IN
cord-254492-42d77vxf	307	17	several	several	JJ
cord-254492-42d77vxf	307	18	ways	way	NNS
cord-254492-42d77vxf	307	19	.	.	.
cord-254492-42d77vxf	308	1	The	the	DT
cord-254492-42d77vxf	308	2	IRF3-Pin1	IRF3-Pin1	NNP
cord-254492-42d77vxf	308	3	interaction	interaction	NN
cord-254492-42d77vxf	308	4	is	be	VBZ
cord-254492-42d77vxf	308	5	inhibited	inhibit	VBN
cord-254492-42d77vxf	308	6	by	by	IN
cord-254492-42d77vxf	308	7	the	the	DT
cord-254492-42d77vxf	308	8	HECT	HECT	NNS
cord-254492-42d77vxf	308	9	(	(	-LRB-
cord-254492-42d77vxf	308	10	homologous	homologous	JJ
cord-254492-42d77vxf	308	11	to	to	IN
cord-254492-42d77vxf	308	12	the	the	DT
cord-254492-42d77vxf	308	13	E6-AP	E6-AP	NNP
cord-254492-42d77vxf	308	14	C	C	NNP
cord-254492-42d77vxf	308	15	terminus	terminus	NN
cord-254492-42d77vxf	308	16	)	)	-RRB-
cord-254492-42d77vxf	308	17	domain	domain	NN
cord-254492-42d77vxf	308	18	and	and	CC
cord-254492-42d77vxf	308	19	RCC1-like	rcc1-like	NN
cord-254492-42d77vxf	308	20	domain	domain	NN
cord-254492-42d77vxf	308	21	-	-	HYPH
cord-254492-42d77vxf	308	22	containing	contain	VBG
cord-254492-42d77vxf	308	23	protein	protein	NN
cord-254492-42d77vxf	308	24	5	5	CD
cord-254492-42d77vxf	308	25	(	(	-LRB-
cord-254492-42d77vxf	308	26	HERC5	HERC5	NNP
cord-254492-42d77vxf	308	27	)	)	-RRB-
cord-254492-42d77vxf	308	28	,	,	,
cord-254492-42d77vxf	308	29	which	which	WDT
cord-254492-42d77vxf	308	30	ligates	ligate	VBZ
cord-254492-42d77vxf	308	31	another	another	DT
cord-254492-42d77vxf	308	32	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	308	33	-	-	HYPH
cord-254492-42d77vxf	308	34	like	like	JJ
cord-254492-42d77vxf	308	35	protein	protein	NN
cord-254492-42d77vxf	308	36	,	,	,
cord-254492-42d77vxf	308	37	ISG15	ISG15	NNP
cord-254492-42d77vxf	308	38	,	,	,
cord-254492-42d77vxf	308	39	onto	onto	IN
cord-254492-42d77vxf	308	40	IRF3	IRF3	NNP
cord-254492-42d77vxf	308	41	at	at	IN
cord-254492-42d77vxf	308	42	Lys193	Lys193	NNP
cord-254492-42d77vxf	308	43	,	,	,
cord-254492-42d77vxf	308	44	Lys360	lys360	XX
cord-254492-42d77vxf	308	45	,	,	,
cord-254492-42d77vxf	308	46	and	and	CC
cord-254492-42d77vxf	308	47	Lys366	Lys366	NNP
cord-254492-42d77vxf	308	48	,	,	,
cord-254492-42d77vxf	308	49	thereby	thereby	RB
cord-254492-42d77vxf	308	50	sustaining	sustain	VBG
cord-254492-42d77vxf	308	51	IRF3	IRF3	NNP
cord-254492-42d77vxf	308	52	activation	activation	NN
cord-254492-42d77vxf	308	53	(	(	-LRB-
cord-254492-42d77vxf	308	54	Shi	Shi	NNP
cord-254492-42d77vxf	308	55	et	et	FW
cord-254492-42d77vxf	308	56	al	al	NNP
cord-254492-42d77vxf	308	57	.	.	NNP
cord-254492-42d77vxf	308	58	,	,	,
cord-254492-42d77vxf	308	59	2010	2010	CD
cord-254492-42d77vxf	308	60	)	)	-RRB-
cord-254492-42d77vxf	308	61	.	.	.
cord-254492-42d77vxf	309	1	TRIM21	TRIM21	NNP
cord-254492-42d77vxf	309	2	is	be	VBZ
cord-254492-42d77vxf	309	3	a	a	DT
cord-254492-42d77vxf	309	4	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	309	5	E3	e3	NN
cord-254492-42d77vxf	309	6	described	describe	VBN
cord-254492-42d77vxf	309	7	to	to	IN
cord-254492-42d77vxf	309	8	both	both	DT
cord-254492-42d77vxf	309	9	inhibit	inhibit	VB
cord-254492-42d77vxf	309	10	the	the	DT
cord-254492-42d77vxf	309	11	IRF3-Pin1	IRF3-Pin1	NNP
cord-254492-42d77vxf	309	12	interaction	interaction	NN
cord-254492-42d77vxf	309	13	and	and	CC
cord-254492-42d77vxf	309	14	target	target	VB
cord-254492-42d77vxf	309	15	IRF3	IRF3	NNP
cord-254492-42d77vxf	309	16	for	for	IN
cord-254492-42d77vxf	309	17	proteasomal	proteasomal	JJ
cord-254492-42d77vxf	309	18	degradation	degradation	NN
cord-254492-42d77vxf	309	19	(	(	-LRB-
cord-254492-42d77vxf	309	20	Higgs	Higgs	NNP
cord-254492-42d77vxf	309	21	et	et	NNP
cord-254492-42d77vxf	309	22	al	al	NNP
cord-254492-42d77vxf	309	23	.	.	NNP
cord-254492-42d77vxf	309	24	,	,	,
cord-254492-42d77vxf	309	25	2008	2008	CD
cord-254492-42d77vxf	309	26	;	;	.
cord-254492-42d77vxf	310	1	Yang	Yang	NNP
cord-254492-42d77vxf	310	2	et	et	NNP
cord-254492-42d77vxf	310	3	al	al	NNP
cord-254492-42d77vxf	310	4	.	.	NNP
cord-254492-42d77vxf	310	5	,	,	,
cord-254492-42d77vxf	310	6	2009	2009	CD
cord-254492-42d77vxf	310	7	)	)	-RRB-
cord-254492-42d77vxf	310	8	.	.	.
cord-254492-42d77vxf	311	1	TRIM21	TRIM21	NNP
cord-254492-42d77vxf	311	2	reportedly	reportedly	RB
cord-254492-42d77vxf	311	3	also	also	RB
cord-254492-42d77vxf	311	4	targets	target	VBZ
cord-254492-42d77vxf	311	5	IRF7	IRF7	NNP
cord-254492-42d77vxf	311	6	for	for	IN
cord-254492-42d77vxf	311	7	degradation	degradation	NN
cord-254492-42d77vxf	311	8	upon	upon	IN
cord-254492-42d77vxf	311	9	TLR7	TLR7	NNP
cord-254492-42d77vxf	311	10	or	or	CC
cord-254492-42d77vxf	311	11	TLR9	tlr9	CD
cord-254492-42d77vxf	311	12	activation	activation	NN
cord-254492-42d77vxf	311	13	(	(	-LRB-
cord-254492-42d77vxf	311	14	Higgs	Higgs	NNP
cord-254492-42d77vxf	311	15	et	et	NNP
cord-254492-42d77vxf	311	16	al	al	NNP
cord-254492-42d77vxf	311	17	.	.	NNP
cord-254492-42d77vxf	311	18	,	,	,
cord-254492-42d77vxf	311	19	2010	2010	CD
cord-254492-42d77vxf	311	20	)	)	-RRB-
cord-254492-42d77vxf	311	21	,	,	,
cord-254492-42d77vxf	311	22	although	although	IN
cord-254492-42d77vxf	311	23	the	the	DT
cord-254492-42d77vxf	311	24	TRIM21-dependent	trim21-dependent	NN
cord-254492-42d77vxf	311	25	IRF3	IRF3	NNP
cord-254492-42d77vxf	311	26	/	/	SYM
cord-254492-42d77vxf	311	27	IFR7	ifr7	JJ
cord-254492-42d77vxf	311	28	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	311	29	acceptor	acceptor	NN
cord-254492-42d77vxf	311	30	sites	site	NNS
cord-254492-42d77vxf	311	31	remain	remain	VBP
cord-254492-42d77vxf	311	32	undefined	undefined	JJ
cord-254492-42d77vxf	312	1	(	(	-LRB-
cord-254492-42d77vxf	312	2	Fig	Fig	NNP
cord-254492-42d77vxf	312	3	.	.	.
cord-254492-42d77vxf	312	4	3	3	CD
cord-254492-42d77vxf	312	5	)	)	-RRB-
cord-254492-42d77vxf	312	6	.	.	.
cord-254492-42d77vxf	313	1	JEM	JEM	NNP
cord-254492-42d77vxf	313	2	Vol	Vol	NNP
cord-254492-42d77vxf	313	3	.	.	.
cord-254492-42d77vxf	314	1	213	213	CD
cord-254492-42d77vxf	314	2	,	,	,
cord-254492-42d77vxf	314	3	No	no	UH
cord-254492-42d77vxf	314	4	.	.	.
cord-254492-42d77vxf	315	1	1	1	LS
cord-254492-42d77vxf	316	1	Several	several	JJ
cord-254492-42d77vxf	316	2	additional	additional	JJ
cord-254492-42d77vxf	316	3	E3s	e3s	NN
cord-254492-42d77vxf	316	4	regulate	regulate	VBP
cord-254492-42d77vxf	316	5	IRF	IRF	NNP
cord-254492-42d77vxf	316	6	abundance	abundance	NN
cord-254492-42d77vxf	316	7	.	.	.
cord-254492-42d77vxf	317	1	The	the	DT
cord-254492-42d77vxf	317	2	Skp	Skp	NNP
cord-254492-42d77vxf	317	3	-	-	HYPH
cord-254492-42d77vxf	317	4	Cullin	Cullin	NNP
cord-254492-42d77vxf	317	5	-	-	HYPH
cord-254492-42d77vxf	317	6	F	F	NNP
cord-254492-42d77vxf	317	7	-	-	HYPH
cord-254492-42d77vxf	317	8	box	box	NNP
cord-254492-42d77vxf	317	9	(	(	-LRB-
cord-254492-42d77vxf	317	10	SCF)-containing	scf)-containe	VBG
cord-254492-42d77vxf	317	11	complex	complex	NN
cord-254492-42d77vxf	317	12	,	,	,
cord-254492-42d77vxf	317	13	of	of	IN
cord-254492-42d77vxf	317	14	which	which	WDT
cord-254492-42d77vxf	317	15	cullin1	cullin1	NN
cord-254492-42d77vxf	317	16	(	(	-LRB-
cord-254492-42d77vxf	317	17	Cul1	Cul1	NNP
cord-254492-42d77vxf	317	18	)	)	-RRB-
cord-254492-42d77vxf	317	19	is	be	VBZ
cord-254492-42d77vxf	317	20	a	a	DT
cord-254492-42d77vxf	317	21	core	core	NN
cord-254492-42d77vxf	317	22	component	component	NN
cord-254492-42d77vxf	317	23	,	,	,
cord-254492-42d77vxf	317	24	catalyzes	catalyze	VBZ
cord-254492-42d77vxf	317	25	IRF3	IRF3	NNP
cord-254492-42d77vxf	317	26	degradation	degradation	NN
cord-254492-42d77vxf	317	27	as	as	RB
cord-254492-42d77vxf	317	28	well	well	RB
cord-254492-42d77vxf	317	29	as	as	IN
cord-254492-42d77vxf	317	30	IκB	iκb	JJ
cord-254492-42d77vxf	317	31	degradation	degradation	NN
cord-254492-42d77vxf	317	32	,	,	,
cord-254492-42d77vxf	317	33	promoting	promote	VBG
cord-254492-42d77vxf	317	34	NF	nf	NN
cord-254492-42d77vxf	317	35	-	-	HYPH
cord-254492-42d77vxf	317	36	κB	κb	CD
cord-254492-42d77vxf	317	37	activation	activation	NN
cord-254492-42d77vxf	317	38	(	(	-LRB-
cord-254492-42d77vxf	317	39	Fig	Fig	NNP
cord-254492-42d77vxf	317	40	.	.	.
cord-254492-42d77vxf	318	1	3	3	LS
cord-254492-42d77vxf	318	2	;	;	:
cord-254492-42d77vxf	318	3	Bibeau	Bibeau	NNP
cord-254492-42d77vxf	318	4	-	-	HYPH
cord-254492-42d77vxf	318	5	Poirier	Poirier	NNP
cord-254492-42d77vxf	318	6	et	et	NNP
cord-254492-42d77vxf	318	7	al	al	NNP
cord-254492-42d77vxf	318	8	.	.	NNP
cord-254492-42d77vxf	318	9	,	,	,
cord-254492-42d77vxf	318	10	2006	2006	CD
cord-254492-42d77vxf	318	11	)	)	-RRB-
cord-254492-42d77vxf	318	12	.	.	.
cord-254492-42d77vxf	319	1	RanBP	RanBP	NNS
cord-254492-42d77vxf	319	2	-	-	HYPH
cord-254492-42d77vxf	319	3	type	type	NN
cord-254492-42d77vxf	319	4	and	and	CC
cord-254492-42d77vxf	319	5	C3HC4-type	c3hc4-type	NN
cord-254492-42d77vxf	319	6	zinc	zinc	NN
cord-254492-42d77vxf	319	7	finger	finger	NN
cord-254492-42d77vxf	319	8	-	-	HYPH
cord-254492-42d77vxf	319	9	containing	contain	VBG
cord-254492-42d77vxf	319	10	protein	protein	NN
cord-254492-42d77vxf	319	11	1	1	CD
cord-254492-42d77vxf	319	12	(	(	-LRB-
cord-254492-42d77vxf	319	13	RBCK1	RBCK1	NNP
cord-254492-42d77vxf	319	14	)	)	-RRB-
cord-254492-42d77vxf	319	15	catalyzes	catalyze	VBZ
cord-254492-42d77vxf	319	16	K48-linked	k48-linked	JJ
cord-254492-42d77vxf	319	17	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	319	18	and	and	CC
cord-254492-42d77vxf	319	19	degradation	degradation	NN
cord-254492-42d77vxf	319	20	of	of	IN
cord-254492-42d77vxf	319	21	IRF3	IRF3	NNP
cord-254492-42d77vxf	319	22	during	during	IN
cord-254492-42d77vxf	319	23	viral	viral	JJ
cord-254492-42d77vxf	319	24	infection	infection	NN
cord-254492-42d77vxf	319	25	(	(	-LRB-
cord-254492-42d77vxf	319	26	Fig	fig	NN
cord-254492-42d77vxf	319	27	.	.	.
cord-254492-42d77vxf	320	1	3	3	LS
cord-254492-42d77vxf	320	2	;	;	:
cord-254492-42d77vxf	320	3	Zhang	Zhang	NNP
cord-254492-42d77vxf	320	4	et	et	NNP
cord-254492-42d77vxf	320	5	al	al	NNP
cord-254492-42d77vxf	320	6	.	.	NNP
cord-254492-42d77vxf	320	7	,	,	,
cord-254492-42d77vxf	320	8	2008	2008	CD
cord-254492-42d77vxf	320	9	)	)	-RRB-
cord-254492-42d77vxf	320	10	.	.	.
cord-254492-42d77vxf	321	1	Finally	finally	RB
cord-254492-42d77vxf	321	2	,	,	,
cord-254492-42d77vxf	321	3	the	the	DT
cord-254492-42d77vxf	321	4	forkhead	forkhead	NNP
cord-254492-42d77vxf	321	5	box	box	NNP
cord-254492-42d77vxf	321	6	protein	protein	NNP
cord-254492-42d77vxf	321	7	O1	O1	NNP
cord-254492-42d77vxf	321	8	(	(	-LRB-
cord-254492-42d77vxf	321	9	FoxO1	FoxO1	NNP
cord-254492-42d77vxf	321	10	)	)	-RRB-
cord-254492-42d77vxf	321	11	,	,	,
cord-254492-42d77vxf	321	12	a	a	DT
cord-254492-42d77vxf	321	13	regulator	regulator	NN
cord-254492-42d77vxf	321	14	of	of	IN
cord-254492-42d77vxf	321	15	insulin	insulin	NN
cord-254492-42d77vxf	321	16	signaling	signaling	NN
cord-254492-42d77vxf	321	17	,	,	,
cord-254492-42d77vxf	321	18	binds	bind	VBZ
cord-254492-42d77vxf	321	19	IRF3	IRF3	NNP
cord-254492-42d77vxf	321	20	and	and	CC
cord-254492-42d77vxf	321	21	promotes	promote	VBZ
cord-254492-42d77vxf	321	22	its	-PRON-	PRP$
cord-254492-42d77vxf	321	23	degradation	degradation	NN
cord-254492-42d77vxf	321	24	by	by	IN
cord-254492-42d77vxf	321	25	recruiting	recruit	VBG
cord-254492-42d77vxf	321	26	an	an	DT
cord-254492-42d77vxf	321	27	unknown	unknown	JJ
cord-254492-42d77vxf	321	28	E3	e3	NN
cord-254492-42d77vxf	321	29	.	.	.
cord-254492-42d77vxf	322	1	FoxO1	foxo1	NN
cord-254492-42d77vxf	322	2	also	also	RB
cord-254492-42d77vxf	322	3	negatively	negatively	RB
cord-254492-42d77vxf	322	4	regulates	regulate	VBZ
cord-254492-42d77vxf	322	5	IRF7	IRF7	NNP
cord-254492-42d77vxf	322	6	transcription	transcription	NN
cord-254492-42d77vxf	322	7	(	(	-LRB-
cord-254492-42d77vxf	322	8	Lei	Lei	NNP
cord-254492-42d77vxf	322	9	et	et	FW
cord-254492-42d77vxf	322	10	al	al	NNP
cord-254492-42d77vxf	322	11	.	.	NNP
cord-254492-42d77vxf	322	12	,	,	,
cord-254492-42d77vxf	322	13	2013	2013	CD
cord-254492-42d77vxf	322	14	)	)	-RRB-
cord-254492-42d77vxf	322	15	,	,	,
cord-254492-42d77vxf	322	16	altogether	altogether	RB
cord-254492-42d77vxf	322	17	implying	imply	VBG
cord-254492-42d77vxf	322	18	a	a	DT
cord-254492-42d77vxf	322	19	link	link	NN
cord-254492-42d77vxf	322	20	between	between	IN
cord-254492-42d77vxf	322	21	metabolism	metabolism	NN
cord-254492-42d77vxf	322	22	and	and	CC
cord-254492-42d77vxf	322	23	innate	innate	JJ
cord-254492-42d77vxf	322	24	immune	immune	JJ
cord-254492-42d77vxf	322	25	induction	induction	NN
cord-254492-42d77vxf	322	26	.	.	.
cord-254492-42d77vxf	323	1	Expression	expression	NN
cord-254492-42d77vxf	323	2	of	of	IN
cord-254492-42d77vxf	323	3	Cul1	Cul1	NNP
cord-254492-42d77vxf	323	4	and	and	CC
cord-254492-42d77vxf	323	5	the	the	DT
cord-254492-42d77vxf	323	6	E3s	e3s	NN
cord-254492-42d77vxf	323	7	RBCK1	rbck1	NN
cord-254492-42d77vxf	323	8	,	,	,
cord-254492-42d77vxf	324	1	TRIM21	trim21	UH
cord-254492-42d77vxf	324	2	,	,	,
cord-254492-42d77vxf	324	3	TRIM26	TRIM26	NNP
cord-254492-42d77vxf	324	4	,	,	,
cord-254492-42d77vxf	324	5	and	and	CC
cord-254492-42d77vxf	325	1	HERC5	HERC5	NNP
cord-254492-42d77vxf	325	2	is	be	VBZ
cord-254492-42d77vxf	325	3	IFN-	IFN-	NNP
cord-254492-42d77vxf	326	1	I	-PRON-	PRP
cord-254492-42d77vxf	326	2	inducible	inducible	JJ
cord-254492-42d77vxf	327	1	(	(	-LRB-
cord-254492-42d77vxf	327	2	Henig	Henig	NNP
cord-254492-42d77vxf	327	3	et	et	NNP
cord-254492-42d77vxf	327	4	al	al	NNP
cord-254492-42d77vxf	327	5	.	.	NNP
cord-254492-42d77vxf	327	6	,	,	,
cord-254492-42d77vxf	327	7	2013	2013	CD
cord-254492-42d77vxf	327	8	)	)	-RRB-
cord-254492-42d77vxf	327	9	,	,	.
cord-254492-42d77vxf	328	1	constituting	constitute	VBG
cord-254492-42d77vxf	328	2	a	a	DT
cord-254492-42d77vxf	328	3	multiply	multiply	NN
cord-254492-42d77vxf	328	4	redundant	redundant	JJ
cord-254492-42d77vxf	328	5	negative	negative	JJ
cord-254492-42d77vxf	328	6	feedback	feedback	NN
cord-254492-42d77vxf	328	7	web	web	NN
cord-254492-42d77vxf	328	8	in	in	IN
cord-254492-42d77vxf	328	9	which	which	WDT
cord-254492-42d77vxf	328	10	IFN	IFN	NNP
cord-254492-42d77vxf	328	11	-	-	HYPH
cord-254492-42d77vxf	328	12	I	-PRON-	PRP
cord-254492-42d77vxf	328	13	expression	expression	NN
cord-254492-42d77vxf	328	14	is	be	VBZ
cord-254492-42d77vxf	328	15	self	self	NN
cord-254492-42d77vxf	328	16	-	-	HYPH
cord-254492-42d77vxf	328	17	restraining	restraining	NN
cord-254492-42d77vxf	328	18	.	.	.
cord-254492-42d77vxf	329	1	Not	not	RB
cord-254492-42d77vxf	329	2	so	so	RB
cord-254492-42d77vxf	329	3	fast	fast	RB
cord-254492-42d77vxf	329	4	:	:	:
cord-254492-42d77vxf	329	5	Seizing	seize	VBG
cord-254492-42d77vxf	329	6	the	the	DT
cord-254492-42d77vxf	329	7	penultimate	penultimate	JJ
cord-254492-42d77vxf	329	8	step	step	NN
cord-254492-42d77vxf	329	9	toward	toward	IN
cord-254492-42d77vxf	329	10	antiviral	antiviral	JJ
cord-254492-42d77vxf	329	11	gene	gene	NN
cord-254492-42d77vxf	329	12	transcription	transcription	NN
cord-254492-42d77vxf	329	13	.	.	.
cord-254492-42d77vxf	330	1	IRFs	IRFs	NNP
cord-254492-42d77vxf	330	2	are	be	VBP
cord-254492-42d77vxf	330	3	a	a	DT
cord-254492-42d77vxf	330	4	significant	significant	JJ
cord-254492-42d77vxf	330	5	target	target	NN
cord-254492-42d77vxf	330	6	of	of	IN
cord-254492-42d77vxf	330	7	viral	viral	JJ
cord-254492-42d77vxf	330	8	disruption	disruption	NN
cord-254492-42d77vxf	330	9	,	,	,
cord-254492-42d77vxf	330	10	usually	usually	RB
cord-254492-42d77vxf	330	11	resulting	result	VBG
cord-254492-42d77vxf	330	12	in	in	IN
cord-254492-42d77vxf	330	13	their	-PRON-	PRP$
cord-254492-42d77vxf	330	14	proteasome	proteasome	NN
cord-254492-42d77vxf	330	15	-	-	HYPH
cord-254492-42d77vxf	330	16	mediated	mediate	VBN
cord-254492-42d77vxf	330	17	degradation	degradation	NN
cord-254492-42d77vxf	330	18	.	.	.
cord-254492-42d77vxf	331	1	Rotavirus	Rotavirus	NNP
cord-254492-42d77vxf	331	2	(	(	-LRB-
cord-254492-42d77vxf	331	3	RoV	RoV	NNP
cord-254492-42d77vxf	331	4	)	)	-RRB-
cord-254492-42d77vxf	331	5	nonstructural	nonstructural	JJ
cord-254492-42d77vxf	331	6	protein	protein	NN
cord-254492-42d77vxf	331	7	1	1	CD
cord-254492-42d77vxf	331	8	blocks	block	NNS
cord-254492-42d77vxf	332	1	NF	NF	NNP
cord-254492-42d77vxf	332	2	-	-	HYPH
cord-254492-42d77vxf	332	3	κB	κB	NNP
cord-254492-42d77vxf	332	4	signaling	signal	VBG
cord-254492-42d77vxf	332	5	and	and	CC
cord-254492-42d77vxf	332	6	usurps	usurp	VBZ
cord-254492-42d77vxf	332	7	the	the	DT
cord-254492-42d77vxf	332	8	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	332	9	modification	modification	NN
cord-254492-42d77vxf	332	10	system	system	NN
cord-254492-42d77vxf	332	11	to	to	TO
cord-254492-42d77vxf	332	12	redirect	redirect	VB
cord-254492-42d77vxf	332	13	IRF3/5/7/9	IRF3/5/7/9	NNP
cord-254492-42d77vxf	332	14	to	to	IN
cord-254492-42d77vxf	332	15	the	the	DT
cord-254492-42d77vxf	332	16	proteasome	proteasome	NN
cord-254492-42d77vxf	332	17	in	in	IN
cord-254492-42d77vxf	332	18	a	a	DT
cord-254492-42d77vxf	332	19	strain	strain	NN
cord-254492-42d77vxf	332	20	-	-	HYPH
cord-254492-42d77vxf	332	21	specific	specific	JJ
cord-254492-42d77vxf	332	22	manner	manner	NN
cord-254492-42d77vxf	333	1	(	(	-LRB-
cord-254492-42d77vxf	333	2	Fig	Fig	NNP
cord-254492-42d77vxf	333	3	.	.	.
cord-254492-42d77vxf	333	4	3	3	CD
cord-254492-42d77vxf	333	5	;	;	:
cord-254492-42d77vxf	333	6	Morelli	Morelli	NNP
cord-254492-42d77vxf	333	7	et	et	NNP
cord-254492-42d77vxf	333	8	al	al	NNP
cord-254492-42d77vxf	333	9	.	.	NNP
cord-254492-42d77vxf	333	10	,	,	,
cord-254492-42d77vxf	333	11	2015	2015	CD
cord-254492-42d77vxf	333	12	)	)	-RRB-
cord-254492-42d77vxf	333	13	.	.	.
cord-254492-42d77vxf	334	1	Cells	cell	NNS
cord-254492-42d77vxf	334	2	produce	produce	VBP
cord-254492-42d77vxf	334	3	trace	trace	NN
cord-254492-42d77vxf	334	4	quantities	quantity	NNS
cord-254492-42d77vxf	334	5	of	of	IN
cord-254492-42d77vxf	334	6	IFN	IFN	NNP
cord-254492-42d77vxf	334	7	-	-	HYPH
cord-254492-42d77vxf	334	8	I	-PRON-	PRP
cord-254492-42d77vxf	334	9	at	at	IN
cord-254492-42d77vxf	334	10	rest	rest	NN
cord-254492-42d77vxf	334	11	through	through	IN
cord-254492-42d77vxf	334	12	basal	basal	NN
cord-254492-42d77vxf	334	13	activation	activation	NN
cord-254492-42d77vxf	334	14	of	of	IN
cord-254492-42d77vxf	334	15	endogenous	endogenous	JJ
cord-254492-42d77vxf	334	16	IRF3	IRF3	NNP
cord-254492-42d77vxf	334	17	/	/	SYM
cord-254492-42d77vxf	334	18	IRF7	IRF7	NNP
cord-254492-42d77vxf	334	19	,	,	,
cord-254492-42d77vxf	334	20	the	the	DT
cord-254492-42d77vxf	334	21	intracellular	intracellular	JJ
cord-254492-42d77vxf	334	22	concentration	concentration	NN
cord-254492-42d77vxf	334	23	of	of	IN
cord-254492-42d77vxf	334	24	which	which	WDT
cord-254492-42d77vxf	334	25	are	be	VBP
cord-254492-42d77vxf	334	26	regulated	regulate	VBN
cord-254492-42d77vxf	334	27	by	by	IN
cord-254492-42d77vxf	334	28	the	the	DT
cord-254492-42d77vxf	334	29	E3	E3	NNP
cord-254492-42d77vxf	334	30	RTA	RTA	NNP
cord-254492-42d77vxf	334	31	-	-	HYPH
cord-254492-42d77vxf	334	32	associated	associate	VBN
cord-254492-42d77vxf	334	33	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	334	34	ligase	ligase	NN
cord-254492-42d77vxf	334	35	(	(	-LRB-
cord-254492-42d77vxf	334	36	RAUL	RAUL	NNP
cord-254492-42d77vxf	334	37	)	)	-RRB-
cord-254492-42d77vxf	334	38	.	.	.
cord-254492-42d77vxf	335	1	KSHV	KSHV	NNP
cord-254492-42d77vxf	335	2	exploits	exploit	VBZ
cord-254492-42d77vxf	335	3	this	this	DT
cord-254492-42d77vxf	335	4	mechanism	mechanism	NN
cord-254492-42d77vxf	335	5	to	to	TO
cord-254492-42d77vxf	335	6	diminish	diminish	VB
cord-254492-42d77vxf	335	7	immune	immune	JJ
cord-254492-42d77vxf	335	8	signaling	signaling	NN
cord-254492-42d77vxf	335	9	,	,	,
cord-254492-42d77vxf	335	10	recruiting	recruit	VBG
cord-254492-42d77vxf	335	11	USP7	USP7	NNP
cord-254492-42d77vxf	336	1	to	to	TO
cord-254492-42d77vxf	336	2	deubiquitinate	deubiquitinate	VB
cord-254492-42d77vxf	336	3	RAUL	RAUL	NNP
cord-254492-42d77vxf	336	4	and	and	CC
cord-254492-42d77vxf	336	5	thereby	thereby	RB
cord-254492-42d77vxf	336	6	maintain	maintain	VB
cord-254492-42d77vxf	336	7	RAUL	RAUL	NNP
cord-254492-42d77vxf	336	8	-	-	HYPH
cord-254492-42d77vxf	336	9	mediated	mediate	VBN
cord-254492-42d77vxf	336	10	IRF3	IRF3	NNP
cord-254492-42d77vxf	336	11	/	/	SYM
cord-254492-42d77vxf	336	12	IRF7	IRF7	NNP
cord-254492-42d77vxf	336	13	degradation	degradation	NN
cord-254492-42d77vxf	336	14	(	(	-LRB-
cord-254492-42d77vxf	336	15	Yu	Yu	NNP
cord-254492-42d77vxf	336	16	and	and	CC
cord-254492-42d77vxf	336	17	Hayward	Hayward	NNP
cord-254492-42d77vxf	336	18	,	,	,
cord-254492-42d77vxf	336	19	2010	2010	CD
cord-254492-42d77vxf	336	20	)	)	-RRB-
cord-254492-42d77vxf	336	21	.	.	.
cord-254492-42d77vxf	337	1	The	the	DT
cord-254492-42d77vxf	337	2	RAUL	RAUL	NNP
cord-254492-42d77vxf	337	3	-	-	HYPH
cord-254492-42d77vxf	337	4	dependent	dependent	JJ
cord-254492-42d77vxf	337	5	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	337	6	acceptor	acceptor	NN
cord-254492-42d77vxf	337	7	sites	site	NNS
cord-254492-42d77vxf	337	8	on	on	IN
cord-254492-42d77vxf	337	9	IRF3	IRF3	NNP
cord-254492-42d77vxf	337	10	/	/	SYM
cord-254492-42d77vxf	337	11	IRF7	IRF7	NNP
cord-254492-42d77vxf	337	12	remain	remain	VBP
cord-254492-42d77vxf	337	13	unknown	unknown	JJ
cord-254492-42d77vxf	337	14	(	(	-LRB-
cord-254492-42d77vxf	337	15	Fig	fig	NN
cord-254492-42d77vxf	337	16	.	.	.
cord-254492-42d77vxf	337	17	3	3	CD
cord-254492-42d77vxf	337	18	)	)	-RRB-
cord-254492-42d77vxf	337	19	,	,	,
cord-254492-42d77vxf	337	20	but	but	CC
cord-254492-42d77vxf	337	21	better	well	JJR
cord-254492-42d77vxf	337	22	characterization	characterization	NN
cord-254492-42d77vxf	337	23	of	of	IN
cord-254492-42d77vxf	337	24	the	the	DT
cord-254492-42d77vxf	337	25	RAUL	RAUL	NNP
cord-254492-42d77vxf	337	26	-	-	HYPH
cord-254492-42d77vxf	337	27	IRF	IRF	NNP
cord-254492-42d77vxf	337	28	interaction	interaction	NN
cord-254492-42d77vxf	337	29	may	may	MD
cord-254492-42d77vxf	337	30	have	have	VB
cord-254492-42d77vxf	337	31	implications	implication	NNS
cord-254492-42d77vxf	337	32	for	for	IN
cord-254492-42d77vxf	337	33	antiviral	antiviral	JJ
cord-254492-42d77vxf	337	34	and	and	CC
cord-254492-42d77vxf	337	35	autoimmunity	autoimmunity	NN
cord-254492-42d77vxf	337	36	treatments	treatment	NNS
cord-254492-42d77vxf	337	37	.	.	.
cord-254492-42d77vxf	338	1	Furthermore	furthermore	RB
cord-254492-42d77vxf	338	2	,	,	,
cord-254492-42d77vxf	338	3	the	the	DT
cord-254492-42d77vxf	338	4	KSHV	KSHV	NNP
cord-254492-42d77vxf	338	5	RTA	RTA	NNP
cord-254492-42d77vxf	338	6	protein	protein	NN
cord-254492-42d77vxf	338	7	catalyzes	catalyze	VBZ
cord-254492-42d77vxf	338	8	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	338	9	and	and	CC
cord-254492-42d77vxf	338	10	degradation	degradation	NN
cord-254492-42d77vxf	338	11	of	of	IN
cord-254492-42d77vxf	338	12	IRF7	IRF7	NNP
cord-254492-42d77vxf	338	13	and	and	CC
cord-254492-42d77vxf	338	14	MyD88	MyD88	NNP
cord-254492-42d77vxf	339	1	(	(	-LRB-
cord-254492-42d77vxf	339	2	Yu	Yu	NNP
cord-254492-42d77vxf	339	3	et	et	FW
cord-254492-42d77vxf	339	4	al	al	NNP
cord-254492-42d77vxf	339	5	.	.	NNP
cord-254492-42d77vxf	339	6	,	,	,
cord-254492-42d77vxf	339	7	2005	2005	CD
cord-254492-42d77vxf	339	8	)	)	-RRB-
cord-254492-42d77vxf	339	9	.	.	.
cord-254492-42d77vxf	340	1	Thus	thus	RB
cord-254492-42d77vxf	340	2	,	,	,
cord-254492-42d77vxf	340	3	KSHV	KSHV	NNP
cord-254492-42d77vxf	340	4	effectively	effectively	RB
cord-254492-42d77vxf	340	5	terminates	terminate	VBZ
cord-254492-42d77vxf	340	6	several	several	JJ
cord-254492-42d77vxf	340	7	signaling	signal	VBG
cord-254492-42d77vxf	340	8	pathways	pathway	NNS
cord-254492-42d77vxf	340	9	at	at	IN
cord-254492-42d77vxf	340	10	multiple	multiple	JJ
cord-254492-42d77vxf	340	11	stages	stage	NNS
cord-254492-42d77vxf	340	12	.	.	.
cord-254492-42d77vxf	341	1	Similar	similar	JJ
cord-254492-42d77vxf	341	2	to	to	IN
cord-254492-42d77vxf	341	3	KSHV	KSHV	NNP
cord-254492-42d77vxf	341	4	,	,	,
cord-254492-42d77vxf	341	5	HIV	HIV	NNP
cord-254492-42d77vxf	341	6	infection	infection	NN
cord-254492-42d77vxf	341	7	fails	fail	VBZ
cord-254492-42d77vxf	341	8	to	to	TO
cord-254492-42d77vxf	341	9	stimulate	stimulate	VB
cord-254492-42d77vxf	341	10	activation	activation	NN
cord-254492-42d77vxf	341	11	of	of	IN
cord-254492-42d77vxf	341	12	IRF3	IRF3	NNP
cord-254492-42d77vxf	341	13	,	,	,
cord-254492-42d77vxf	341	14	endogenous	endogenous	JJ
cord-254492-42d77vxf	341	15	levels	level	NNS
cord-254492-42d77vxf	341	16	of	of	IN
cord-254492-42d77vxf	341	17	which	which	WDT
cord-254492-42d77vxf	341	18	are	be	VBP
cord-254492-42d77vxf	341	19	quickly	quickly	RB
cord-254492-42d77vxf	341	20	reduced	reduce	VBN
cord-254492-42d77vxf	341	21	upon	upon	IN
cord-254492-42d77vxf	341	22	infection	infection	NN
cord-254492-42d77vxf	341	23	.	.	.
cord-254492-42d77vxf	342	1	Underscoring	underscore	VBG
cord-254492-42d77vxf	342	2	the	the	DT
cord-254492-42d77vxf	342	3	importance	importance	NN
cord-254492-42d77vxf	342	4	for	for	IN
cord-254492-42d77vxf	342	5	HIV	HIV	NNP
cord-254492-42d77vxf	342	6	to	to	TO
cord-254492-42d77vxf	342	7	disrupt	disrupt	VB
cord-254492-42d77vxf	342	8	early	early	JJ
cord-254492-42d77vxf	342	9	IFN	IFN	NNP
cord-254492-42d77vxf	342	10	-	-	HYPH
cord-254492-42d77vxf	342	11	I	I	NNP
cord-254492-42d77vxf	342	12	-	-	HYPH
cord-254492-42d77vxf	342	13	mediated	mediate	VBN
cord-254492-42d77vxf	342	14	immunity	immunity	NN
cord-254492-42d77vxf	342	15	,	,	,
cord-254492-42d77vxf	342	16	IRF3	IRF3	NNP
cord-254492-42d77vxf	342	17	degradation	degradation	NN
cord-254492-42d77vxf	342	18	is	be	VBZ
cord-254492-42d77vxf	342	19	independently	independently	RB
cord-254492-42d77vxf	342	20	promoted	promote	VBN
cord-254492-42d77vxf	342	21	by	by	IN
cord-254492-42d77vxf	342	22	two	two	CD
cord-254492-42d77vxf	342	23	viral	viral	JJ
cord-254492-42d77vxf	342	24	accessory	accessory	NN
cord-254492-42d77vxf	342	25	proteins	protein	NNS
cord-254492-42d77vxf	342	26	,	,	,
cord-254492-42d77vxf	342	27	viral	viral	JJ
cord-254492-42d77vxf	342	28	infectivity	infectivity	NN
cord-254492-42d77vxf	342	29	factor	factor	NN
cord-254492-42d77vxf	342	30	(	(	-LRB-
cord-254492-42d77vxf	342	31	Vif	Vif	NNP
cord-254492-42d77vxf	342	32	)	)	-RRB-
cord-254492-42d77vxf	342	33	and	and	CC
cord-254492-42d77vxf	342	34	viral	viral	JJ
cord-254492-42d77vxf	342	35	protein	protein	NN
cord-254492-42d77vxf	342	36	R	r	NN
cord-254492-42d77vxf	342	37	(	(	-LRB-
cord-254492-42d77vxf	342	38	Vpr	Vpr	NNP
cord-254492-42d77vxf	342	39	)	)	-RRB-
cord-254492-42d77vxf	342	40	.	.	.
cord-254492-42d77vxf	343	1	The	the	DT
cord-254492-42d77vxf	343	2	E3s	e3s	NN
cord-254492-42d77vxf	343	3	hijacked	hijack	VBD
cord-254492-42d77vxf	343	4	for	for	IN
cord-254492-42d77vxf	343	5	this	this	DT
cord-254492-42d77vxf	343	6	purpose	purpose	NN
cord-254492-42d77vxf	343	7	are	be	VBP
cord-254492-42d77vxf	343	8	unknown	unknown	JJ
cord-254492-42d77vxf	344	1	(	(	-LRB-
cord-254492-42d77vxf	344	2	Fig	Fig	NNP
cord-254492-42d77vxf	344	3	.	.	.
cord-254492-42d77vxf	344	4	3	3	CD
cord-254492-42d77vxf	344	5	)	)	-RRB-
cord-254492-42d77vxf	344	6	,	,	,
cord-254492-42d77vxf	344	7	although	although	IN
cord-254492-42d77vxf	344	8	Vif	Vif	NNP
cord-254492-42d77vxf	344	9	and	and	CC
cord-254492-42d77vxf	344	10	Vpr	Vpr	NNP
cord-254492-42d77vxf	344	11	recruit	recruit	VB
cord-254492-42d77vxf	344	12	SCF	scf	NN
cord-254492-42d77vxf	344	13	-	-	HYPH
cord-254492-42d77vxf	344	14	related	relate	VBN
cord-254492-42d77vxf	344	15	components	component	NNS
cord-254492-42d77vxf	344	16	to	to	TO
cord-254492-42d77vxf	344	17	degrade	degrade	VB
cord-254492-42d77vxf	344	18	other	other	JJ
cord-254492-42d77vxf	344	19	antiviral	antiviral	JJ
cord-254492-42d77vxf	344	20	proteins	protein	NNS
cord-254492-42d77vxf	345	1	(	(	-LRB-
cord-254492-42d77vxf	345	2	Okumura	Okumura	NNP
cord-254492-42d77vxf	345	3	et	et	NNP
cord-254492-42d77vxf	345	4	al	al	NNP
cord-254492-42d77vxf	345	5	.	.	NNP
cord-254492-42d77vxf	345	6	,	,	,
cord-254492-42d77vxf	345	7	2008	2008	CD
cord-254492-42d77vxf	345	8	)	)	-RRB-
cord-254492-42d77vxf	345	9	.	.	.
cord-254492-42d77vxf	346	1	The	the	DT
cord-254492-42d77vxf	346	2	innate	innate	JJ
cord-254492-42d77vxf	346	3	immune	immune	JJ
cord-254492-42d77vxf	346	4	signaling	signal	VBG
cord-254492-42d77vxf	346	5	architecture	architecture	NN
cord-254492-42d77vxf	346	6	is	be	VBZ
cord-254492-42d77vxf	346	7	complex	complex	JJ
cord-254492-42d77vxf	346	8	and	and	CC
cord-254492-42d77vxf	346	9	has	have	VBZ
cord-254492-42d77vxf	346	10	coevolved	coevolve	VBN
cord-254492-42d77vxf	346	11	with	with	IN
cord-254492-42d77vxf	346	12	the	the	DT
cord-254492-42d77vxf	346	13	pathogens	pathogen	NNS
cord-254492-42d77vxf	346	14	it	-PRON-	PRP
cord-254492-42d77vxf	346	15	guards	guard	VBZ
cord-254492-42d77vxf	346	16	against	against	IN
cord-254492-42d77vxf	346	17	,	,	,
cord-254492-42d77vxf	346	18	meanwhile	meanwhile	RB
cord-254492-42d77vxf	346	19	restraining	restrain	VBG
cord-254492-42d77vxf	346	20	autoimmunity	autoimmunity	NN
cord-254492-42d77vxf	346	21	through	through	IN
cord-254492-42d77vxf	346	22	an	an	DT
cord-254492-42d77vxf	346	23	elaborate	elaborate	JJ
cord-254492-42d77vxf	346	24	negative	negative	JJ
cord-254492-42d77vxf	346	25	feedback	feedback	NN
cord-254492-42d77vxf	346	26	scheme	scheme	NN
cord-254492-42d77vxf	346	27	.	.	.
cord-254492-42d77vxf	347	1	A	a	DT
cord-254492-42d77vxf	347	2	cornerstone	cornerstone	NN
cord-254492-42d77vxf	347	3	of	of	IN
cord-254492-42d77vxf	347	4	this	this	DT
cord-254492-42d77vxf	347	5	dynamic	dynamic	JJ
cord-254492-42d77vxf	347	6	regulatory	regulatory	JJ
cord-254492-42d77vxf	347	7	framework	framework	NN
cord-254492-42d77vxf	347	8	is	be	VBZ
cord-254492-42d77vxf	347	9	the	the	DT
cord-254492-42d77vxf	347	10	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	347	11	modification	modification	NN
cord-254492-42d77vxf	347	12	system	system	NN
cord-254492-42d77vxf	347	13	,	,	,
cord-254492-42d77vxf	347	14	which	which	WDT
cord-254492-42d77vxf	347	15	is	be	VBZ
cord-254492-42d77vxf	347	16	manipulated	manipulate	VBN
cord-254492-42d77vxf	347	17	by	by	IN
cord-254492-42d77vxf	347	18	viruses	virus	NNS
cord-254492-42d77vxf	347	19	relevant	relevant	JJ
cord-254492-42d77vxf	347	20	to	to	IN
cord-254492-42d77vxf	347	21	human	human	JJ
cord-254492-42d77vxf	347	22	disease	disease	NN
cord-254492-42d77vxf	347	23	.	.	.
cord-254492-42d77vxf	348	1	Going	go	VBG
cord-254492-42d77vxf	348	2	forward	forward	RB
cord-254492-42d77vxf	348	3	in	in	IN
cord-254492-42d77vxf	348	4	understanding	understand	VBG
cord-254492-42d77vxf	348	5	mechanisms	mechanism	NNS
cord-254492-42d77vxf	348	6	of	of	IN
cord-254492-42d77vxf	348	7	infection	infection	NN
cord-254492-42d77vxf	348	8	and	and	CC
cord-254492-42d77vxf	348	9	autoimmunity	autoimmunity	NN
cord-254492-42d77vxf	348	10	,	,	,
cord-254492-42d77vxf	348	11	we	-PRON-	PRP
cord-254492-42d77vxf	348	12	must	must	MD
cord-254492-42d77vxf	348	13	address	address	VB
cord-254492-42d77vxf	348	14	significant	significant	JJ
cord-254492-42d77vxf	348	15	gaps	gap	NNS
cord-254492-42d77vxf	348	16	in	in	IN
cord-254492-42d77vxf	348	17	knowledge	knowledge	NN
cord-254492-42d77vxf	348	18	regarding	regard	VBG
cord-254492-42d77vxf	348	19	the	the	DT
cord-254492-42d77vxf	348	20	specificity	specificity	NN
cord-254492-42d77vxf	348	21	and	and	CC
cord-254492-42d77vxf	348	22	context	context	NN
cord-254492-42d77vxf	348	23	-	-	HYPH
cord-254492-42d77vxf	348	24	dependent	dependent	JJ
cord-254492-42d77vxf	348	25	regulation	regulation	NN
cord-254492-42d77vxf	348	26	of	of	IN
cord-254492-42d77vxf	348	27	E3s	e3s	NN
cord-254492-42d77vxf	348	28	and	and	CC
cord-254492-42d77vxf	348	29	DUbs	DUbs	NNP
cord-254492-42d77vxf	348	30	and	and	CC
cord-254492-42d77vxf	348	31	the	the	DT
cord-254492-42d77vxf	348	32	consequences	consequence	NNS
cord-254492-42d77vxf	348	33	of	of	IN
cord-254492-42d77vxf	348	34	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	348	35	modification	modification	NN
cord-254492-42d77vxf	348	36	.	.	.
cord-254492-42d77vxf	349	1	This	this	DT
cord-254492-42d77vxf	349	2	will	will	MD
cord-254492-42d77vxf	349	3	expose	expose	VB
cord-254492-42d77vxf	349	4	further	further	JJ
cord-254492-42d77vxf	349	5	cross	cross	NN
cord-254492-42d77vxf	349	6	-	-	NN
cord-254492-42d77vxf	349	7	talk	talk	NN
cord-254492-42d77vxf	349	8	between	between	IN
cord-254492-42d77vxf	349	9	the	the	DT
cord-254492-42d77vxf	349	10	immune	immune	JJ
cord-254492-42d77vxf	349	11	signaling	signaling	NN
cord-254492-42d77vxf	349	12	cascades	cascade	NNS
cord-254492-42d77vxf	349	13	,	,	,
cord-254492-42d77vxf	349	14	revealing	reveal	VBG
cord-254492-42d77vxf	349	15	a	a	DT
cord-254492-42d77vxf	349	16	functional	functional	JJ
cord-254492-42d77vxf	349	17	and	and	CC
cord-254492-42d77vxf	349	18	self	self	NN
cord-254492-42d77vxf	349	19	-	-	HYPH
cord-254492-42d77vxf	349	20	regulating	regulate	VBG
cord-254492-42d77vxf	349	21	whole	whole	NN
cord-254492-42d77vxf	349	22	.	.	.
cord-254492-42d77vxf	350	1	In	in	IN
cord-254492-42d77vxf	350	2	the	the	DT
cord-254492-42d77vxf	350	3	search	search	NN
cord-254492-42d77vxf	350	4	for	for	IN
cord-254492-42d77vxf	350	5	a	a	DT
cord-254492-42d77vxf	350	6	new	new	JJ
cord-254492-42d77vxf	350	7	generation	generation	NN
cord-254492-42d77vxf	350	8	of	of	IN
cord-254492-42d77vxf	350	9	antiviral	antiviral	JJ
cord-254492-42d77vxf	350	10	and	and	CC
cord-254492-42d77vxf	350	11	autoimmune	autoimmune	JJ
cord-254492-42d77vxf	350	12	treatments	treatment	NNS
cord-254492-42d77vxf	350	13	,	,	,
cord-254492-42d77vxf	350	14	we	-PRON-	PRP
cord-254492-42d77vxf	350	15	continue	continue	VBP
cord-254492-42d77vxf	350	16	to	to	TO
cord-254492-42d77vxf	350	17	learn	learn	VB
cord-254492-42d77vxf	350	18	from	from	IN
cord-254492-42d77vxf	350	19	the	the	DT
cord-254492-42d77vxf	350	20	pathogens	pathogen	NNS
cord-254492-42d77vxf	350	21	that	that	WDT
cord-254492-42d77vxf	350	22	have	have	VBP
cord-254492-42d77vxf	350	23	long	long	RB
cord-254492-42d77vxf	350	24	adapted	adapt	VBN
cord-254492-42d77vxf	350	25	to	to	TO
cord-254492-42d77vxf	350	26	exploit	exploit	VB
cord-254492-42d77vxf	350	27	this	this	DT
cord-254492-42d77vxf	350	28	ready	ready	RB
cord-254492-42d77vxf	350	29	-	-	HYPH
cord-254492-42d77vxf	350	30	made	make	VBN
cord-254492-42d77vxf	350	31	system	system	NN
cord-254492-42d77vxf	350	32	of	of	IN
cord-254492-42d77vxf	350	33	functional	functional	JJ
cord-254492-42d77vxf	350	34	regulation	regulation	NN
cord-254492-42d77vxf	350	35	;	;	:
cord-254492-42d77vxf	350	36	humans	human	NNS
cord-254492-42d77vxf	350	37	possess	possess	VBP
cord-254492-42d77vxf	350	38	hundreds	hundred	NNS
cord-254492-42d77vxf	350	39	of	of	IN
cord-254492-42d77vxf	350	40	specific	specific	JJ
cord-254492-42d77vxf	350	41	-	-	HYPH
cord-254492-42d77vxf	350	42	and	and	CC
cord-254492-42d77vxf	350	43	general	general	JJ
cord-254492-42d77vxf	350	44	-	-	HYPH
cord-254492-42d77vxf	350	45	effect	effect	NN
cord-254492-42d77vxf	350	46	E3s	e3s	NN
cord-254492-42d77vxf	350	47	and	and	CC
cord-254492-42d77vxf	350	48	DUbs	DUbs	NNP
cord-254492-42d77vxf	350	49	,	,	,
cord-254492-42d77vxf	350	50	many	many	JJ
cord-254492-42d77vxf	350	51	of	of	IN
cord-254492-42d77vxf	350	52	which	which	WDT
cord-254492-42d77vxf	350	53	could	could	MD
cord-254492-42d77vxf	350	54	be	be	VB
cord-254492-42d77vxf	350	55	harnessed	harness	VBN
cord-254492-42d77vxf	350	56	for	for	IN
cord-254492-42d77vxf	350	57	therapeutic	therapeutic	JJ
cord-254492-42d77vxf	350	58	use	use	NN
cord-254492-42d77vxf	350	59	.	.	.
cord-254492-42d77vxf	350	60	 	 	_SP
cord-254492-42d77vxf	351	1	Kaposi	Kaposi	NNP
cord-254492-42d77vxf	351	2	sarcoma	sarcoma	NN
cord-254492-42d77vxf	351	3	-	-	HYPH
cord-254492-42d77vxf	351	4	associated	associate	VBN
cord-254492-42d77vxf	351	5	herpesvirus	herpesvirus	NN
cord-254492-42d77vxf	351	6	degrades	degrade	VBZ
cord-254492-42d77vxf	351	7	cellular	cellular	JJ
cord-254492-42d77vxf	351	8	Toll	toll	NN
cord-254492-42d77vxf	351	9	-	-	HYPH
cord-254492-42d77vxf	351	10	interleukin-1	interleukin-1	NN
cord-254492-42d77vxf	351	11	receptor	receptor	NN
cord-254492-42d77vxf	351	12	domain	domain	NN
cord-254492-42d77vxf	351	13	-	-	HYPH
cord-254492-42d77vxf	351	14	containing	contain	VBG
cord-254492-42d77vxf	351	15	adaptor	adaptor	NN
cord-254492-42d77vxf	351	16	-	-	HYPH
cord-254492-42d77vxf	351	17	inducing	induce	VBG
cord-254492-42d77vxf	351	18	β	β	NN
cord-254492-42d77vxf	351	19	-	-	HYPH
cord-254492-42d77vxf	351	20	interferon	interferon	NNP
cord-254492-42d77vxf	351	21	(	(	-LRB-
cord-254492-42d77vxf	351	22	TRIF	TRIF	NNP
cord-254492-42d77vxf	351	23	)	)	-RRB-
cord-254492-42d77vxf	352	1	Negative	negative	JJ
cord-254492-42d77vxf	352	2	regulation	regulation	NN
cord-254492-42d77vxf	352	3	of	of	IN
cord-254492-42d77vxf	352	4	the	the	DT
cord-254492-42d77vxf	352	5	RIG	rig	NN
cord-254492-42d77vxf	353	1	-I	-i	DT
cord-254492-42d77vxf	353	2	signaling	signal	VBG
cord-254492-42d77vxf	353	3	by	by	IN
cord-254492-42d77vxf	353	4	the	the	DT
cord-254492-42d77vxf	353	5	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	353	6	ligase	ligase	NN
cord-254492-42d77vxf	354	1	RNF125	RNF125	NNP
cord-254492-42d77vxf	355	1	Influenza	Influenza	NNP
cord-254492-42d77vxf	355	2	A	a	DT
cord-254492-42d77vxf	355	3	virus	virus	NN
cord-254492-42d77vxf	355	4	uses	use	VBZ
cord-254492-42d77vxf	355	5	the	the	DT
cord-254492-42d77vxf	355	6	aggresome	aggresome	JJ
cord-254492-42d77vxf	355	7	processing	processing	NN
cord-254492-42d77vxf	355	8	machinery	machinery	NN
cord-254492-42d77vxf	355	9	for	for	IN
cord-254492-42d77vxf	355	10	host	host	NN
cord-254492-42d77vxf	355	11	cell	cell	NN
cord-254492-42d77vxf	355	12	entry	entry	NN
cord-254492-42d77vxf	355	13	Involvement	Involvement	NNP
cord-254492-42d77vxf	355	14	of	of	IN
cord-254492-42d77vxf	355	15	the	the	DT
cord-254492-42d77vxf	355	16	IκB	iκb	NN
cord-254492-42d77vxf	355	17	kinase	kinase	NN
cord-254492-42d77vxf	355	18	(	(	-LRB-
cord-254492-42d77vxf	355	19	IKK)-related	ikk)-relate	VBN
cord-254492-42d77vxf	355	20	kinases	kinase	NNS
cord-254492-42d77vxf	355	21	tank	tank	NN
cord-254492-42d77vxf	355	22	-	-	HYPH
cord-254492-42d77vxf	355	23	binding	bind	VBG
cord-254492-42d77vxf	355	24	kinase	kinase	NN
cord-254492-42d77vxf	355	25	1	1	CD
cord-254492-42d77vxf	355	26	/	/	SYM
cord-254492-42d77vxf	355	27	IKKi	IKKi	NNP
cord-254492-42d77vxf	355	28	and	and	CC
cord-254492-42d77vxf	355	29	cullin	cullin	NNP
cord-254492-42d77vxf	355	30	-	-	HYPH
cord-254492-42d77vxf	355	31	based	base	VBN
cord-254492-42d77vxf	355	32	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	355	33	ligases	ligase	NNS
cord-254492-42d77vxf	355	34	in	in	IN
cord-254492-42d77vxf	355	35	IFN	IFN	NNP
cord-254492-42d77vxf	355	36	regulatory	regulatory	JJ
cord-254492-42d77vxf	355	37	factor-3	factor-3	NNP
cord-254492-42d77vxf	355	38	degradation	degradation	NN
cord-254492-42d77vxf	355	39	CARD	card	NN
cord-254492-42d77vxf	355	40	games	game	NNS
cord-254492-42d77vxf	355	41	in	in	IN
cord-254492-42d77vxf	355	42	apoptosis	apoptosis	NN
cord-254492-42d77vxf	355	43	and	and	CC
cord-254492-42d77vxf	355	44	immunity	immunity	NN
cord-254492-42d77vxf	356	1	The	the	DT
cord-254492-42d77vxf	356	2	innate	innate	JJ
cord-254492-42d77vxf	356	3	immune	immune	JJ
cord-254492-42d77vxf	356	4	sensor	sensor	NN
cord-254492-42d77vxf	356	5	LGP2	LGP2	NNP
cord-254492-42d77vxf	356	6	activates	activate	VBZ
cord-254492-42d77vxf	356	7	antiviral	antiviral	JJ
cord-254492-42d77vxf	356	8	signaling	signal	VBG
cord-254492-42d77vxf	356	9	by	by	IN
cord-254492-42d77vxf	356	10	regulating	regulate	VBG
cord-254492-42d77vxf	356	11	MDA5-RNA	MDA5-RNA	NNP
cord-254492-42d77vxf	356	12	interaction	interaction	NN
cord-254492-42d77vxf	356	13	and	and	CC
cord-254492-42d77vxf	356	14	filament	filament	NN
cord-254492-42d77vxf	356	15	assembly	assembly	NN
cord-254492-42d77vxf	356	16	MAVS	mavs	RB
cord-254492-42d77vxf	356	17	ubiquitination	ubiquitination	IN
cord-254492-42d77vxf	356	18	by	by	IN
cord-254492-42d77vxf	356	19	the	the	DT
cord-254492-42d77vxf	356	20	E3	e3	NN
cord-254492-42d77vxf	356	21	ligase	ligase	NN
cord-254492-42d77vxf	356	22	TRIM25	trim25	NN
cord-254492-42d77vxf	356	23	and	and	CC
cord-254492-42d77vxf	356	24	degradation	degradation	NN
cord-254492-42d77vxf	356	25	by	by	IN
cord-254492-42d77vxf	356	26	the	the	DT
cord-254492-42d77vxf	356	27	proteasome	proteasome	NN
cord-254492-42d77vxf	356	28	is	be	VBZ
cord-254492-42d77vxf	356	29	involved	involve	VBN
cord-254492-42d77vxf	356	30	in	in	IN
cord-254492-42d77vxf	356	31	type	type	NN
cord-254492-42d77vxf	357	1	I	-PRON-	PRP
cord-254492-42d77vxf	357	2	interferon	interferon	VBD
cord-254492-42d77vxf	357	3	production	production	NN
cord-254492-42d77vxf	357	4	after	after	IN
cord-254492-42d77vxf	357	5	activation	activation	NN
cord-254492-42d77vxf	357	6	of	of	IN
cord-254492-42d77vxf	357	7	the	the	DT
cord-254492-42d77vxf	357	8	antiviral	antiviral	JJ
cord-254492-42d77vxf	357	9	RIG	rig	NN
cord-254492-42d77vxf	357	10	-	-	HYPH
cord-254492-42d77vxf	357	11	I	i	NN
cord-254492-42d77vxf	357	12	-	-	HYPH
cord-254492-42d77vxf	357	13	like	like	JJ
cord-254492-42d77vxf	357	14	receptors	receptor	NNS
cord-254492-42d77vxf	357	15	Ring	ring	VBP
cord-254492-42d77vxf	357	16	finger	finger	NN
cord-254492-42d77vxf	357	17	protein	protein	NN
cord-254492-42d77vxf	357	18	166	166	CD
cord-254492-42d77vxf	357	19	potentiates	potentiate	VBZ
cord-254492-42d77vxf	357	20	RNA	RNA	NNP
cord-254492-42d77vxf	357	21	virus	virus	NN
cord-254492-42d77vxf	357	22	-	-	HYPH
cord-254492-42d77vxf	357	23	induced	induce	VBN
cord-254492-42d77vxf	357	24	interferon	interferon	NN
cord-254492-42d77vxf	357	25	-	-	HYPH
cord-254492-42d77vxf	357	26	β	β	NN
cord-254492-42d77vxf	357	27	production	production	NN
cord-254492-42d77vxf	357	28	via	via	IN
cord-254492-42d77vxf	357	29	enhancing	enhance	VBG
cord-254492-42d77vxf	357	30	the	the	DT
cord-254492-42d77vxf	357	31	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	357	32	of	of	IN
cord-254492-42d77vxf	357	33	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	357	34	and	and	CC
cord-254492-42d77vxf	357	35	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	357	36	Activation	Activation	NNP
cord-254492-42d77vxf	357	37	of	of	IN
cord-254492-42d77vxf	357	38	the	the	DT
cord-254492-42d77vxf	357	39	canonical	canonical	JJ
cord-254492-42d77vxf	357	40	IKK	IKK	NNP
cord-254492-42d77vxf	357	41	complex	complex	NN
cord-254492-42d77vxf	357	42	by	by	IN
cord-254492-42d77vxf	357	43	K63	K63	NNP
cord-254492-42d77vxf	357	44	/	/	SYM
cord-254492-42d77vxf	357	45	M1-linked	m1-linke	VBD
cord-254492-42d77vxf	357	46	hybrid	hybrid	JJ
cord-254492-42d77vxf	357	47	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	357	48	chains	chain	NNS
cord-254492-42d77vxf	358	1	A	a	DT
cord-254492-42d77vxf	358	2	novel	novel	NN
cord-254492-42d77vxf	358	3	PAAD	PAAD	NNP
cord-254492-42d77vxf	358	4	-	-	HYPH
cord-254492-42d77vxf	358	5	containing	contain	VBG
cord-254492-42d77vxf	358	6	protein	protein	NN
cord-254492-42d77vxf	358	7	that	that	WDT
cord-254492-42d77vxf	358	8	modulates	modulate	VBZ
cord-254492-42d77vxf	358	9	NF	nf	NN
cord-254492-42d77vxf	358	10	-	-	HYPH
cord-254492-42d77vxf	358	11	κB	κb	CD
cord-254492-42d77vxf	358	12	induction	induction	NN
cord-254492-42d77vxf	358	13	by	by	IN
cord-254492-42d77vxf	358	14	cytokines	cytokine	NNS
cord-254492-42d77vxf	358	15	tumor	tumor	NN
cord-254492-42d77vxf	358	16	necrosis	necrosis	NN
cord-254492-42d77vxf	358	17	factor	factor	NN
cord-254492-42d77vxf	358	18	-	-	HYPH
cord-254492-42d77vxf	358	19	α	α	NN
cord-254492-42d77vxf	358	20	and	and	CC
cord-254492-42d77vxf	358	21	interleukin-1β	interleukin-1β	NNP
cord-254492-42d77vxf	359	1	The	the	DT
cord-254492-42d77vxf	359	2	tumour	tumour	NN
cord-254492-42d77vxf	359	3	suppressor	suppressor	NN
cord-254492-42d77vxf	359	4	CYLD	CYLD	NNP
cord-254492-42d77vxf	359	5	is	be	VBZ
cord-254492-42d77vxf	359	6	a	a	DT
cord-254492-42d77vxf	359	7	negative	negative	JJ
cord-254492-42d77vxf	359	8	regulator	regulator	NN
cord-254492-42d77vxf	359	9	of	of	IN
cord-254492-42d77vxf	359	10	RIG	rig	NN
cord-254492-42d77vxf	359	11	-	-	HYPH
cord-254492-42d77vxf	359	12	Imediated	imediate	VBN
cord-254492-42d77vxf	359	13	antiviral	antiviral	JJ
cord-254492-42d77vxf	359	14	response	response	NN
cord-254492-42d77vxf	360	1	TRIM25	trim25	CD
cord-254492-42d77vxf	360	2	RING	ring	NN
cord-254492-42d77vxf	360	3	-	-	HYPH
cord-254492-42d77vxf	360	4	finger	finger	NN
cord-254492-42d77vxf	360	5	E3	e3	NN
cord-254492-42d77vxf	360	6	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	360	7	ligase	ligase	NN
cord-254492-42d77vxf	360	8	is	be	VBZ
cord-254492-42d77vxf	360	9	essential	essential	JJ
cord-254492-42d77vxf	360	10	for	for	IN
cord-254492-42d77vxf	360	11	RIG	rig	NN
cord-254492-42d77vxf	360	12	-	-	HYPH
cord-254492-42d77vxf	360	13	I	i	NN
cord-254492-42d77vxf	360	14	-	-	HYPH
cord-254492-42d77vxf	360	15	mediated	mediate	VBN
cord-254492-42d77vxf	360	16	antiviral	antiviral	JJ
cord-254492-42d77vxf	360	17	activity	activity	NN
cord-254492-42d77vxf	360	18	Influenza	Influenza	NNP
cord-254492-42d77vxf	360	19	A	a	DT
cord-254492-42d77vxf	360	20	virus	virus	NN
cord-254492-42d77vxf	360	21	NS1	ns1	CD
cord-254492-42d77vxf	360	22	targets	target	VBZ
cord-254492-42d77vxf	360	23	the	the	DT
cord-254492-42d77vxf	360	24	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	360	25	ligase	ligase	NN
cord-254492-42d77vxf	360	26	TRIM25	TRIM25	NNP
cord-254492-42d77vxf	360	27	to	to	TO
cord-254492-42d77vxf	360	28	evade	evade	VB
cord-254492-42d77vxf	360	29	recognition	recognition	NN
cord-254492-42d77vxf	360	30	by	by	IN
cord-254492-42d77vxf	360	31	the	the	DT
cord-254492-42d77vxf	360	32	host	host	NN
cord-254492-42d77vxf	360	33	viral	viral	JJ
cord-254492-42d77vxf	360	34	RNA	RNA	NNP
cord-254492-42d77vxf	360	35	sensor	sensor	NN
cord-254492-42d77vxf	360	36	RIG	rig	NN
cord-254492-42d77vxf	361	1	-I	-i	WDT
cord-254492-42d77vxf	361	2	REUL	REUL	NNP
cord-254492-42d77vxf	361	3	is	be	VBZ
cord-254492-42d77vxf	361	4	a	a	DT
cord-254492-42d77vxf	361	5	novel	novel	JJ
cord-254492-42d77vxf	361	6	E3	e3	NN
cord-254492-42d77vxf	361	7	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	361	8	ligase	ligase	NN
cord-254492-42d77vxf	361	9	and	and	CC
cord-254492-42d77vxf	361	10	stimulator	stimulator	NN
cord-254492-42d77vxf	361	11	of	of	IN
cord-254492-42d77vxf	361	12	retinoic	retinoic	JJ
cord-254492-42d77vxf	361	13	-	-	HYPH
cord-254492-42d77vxf	361	14	acid	acid	NN
cord-254492-42d77vxf	361	15	-	-	HYPH
cord-254492-42d77vxf	361	16	inducible	inducible	JJ
cord-254492-42d77vxf	361	17	gene	gene	NN
cord-254492-42d77vxf	361	18	-	-	:
cord-254492-42d77vxf	361	19	I	-PRON-	PRP
cord-254492-42d77vxf	361	20	Functional	functional	JJ
cord-254492-42d77vxf	361	21	dissection	dissection	NN
cord-254492-42d77vxf	361	22	of	of	IN
cord-254492-42d77vxf	361	23	the	the	DT
cord-254492-42d77vxf	361	24	TBK1	TBK1	NNP
cord-254492-42d77vxf	361	25	molecular	molecular	JJ
cord-254492-42d77vxf	361	26	network	network	NN
cord-254492-42d77vxf	361	27	Modulation	modulation	NN
cord-254492-42d77vxf	361	28	of	of	IN
cord-254492-42d77vxf	361	29	the	the	DT
cord-254492-42d77vxf	361	30	interferon	interferon	NN
cord-254492-42d77vxf	361	31	antiviral	antiviral	JJ
cord-254492-42d77vxf	361	32	response	response	NN
cord-254492-42d77vxf	361	33	by	by	IN
cord-254492-42d77vxf	361	34	the	the	DT
cord-254492-42d77vxf	361	35	TBK1	TBK1	NNP
cord-254492-42d77vxf	361	36	/	/	SYM
cord-254492-42d77vxf	361	37	IKKi	IKKi	NNP
cord-254492-42d77vxf	361	38	adaptor	adaptor	NN
cord-254492-42d77vxf	361	39	protein	protein	NN
cord-254492-42d77vxf	361	40	TANK	TANK	NNP
cord-254492-42d77vxf	361	41	Ubiquitination	Ubiquitination	NNP
cord-254492-42d77vxf	361	42	and	and	CC
cord-254492-42d77vxf	361	43	translocation	translocation	NN
cord-254492-42d77vxf	361	44	of	of	IN
cord-254492-42d77vxf	361	45	TRAF2	TRAF2	NNP
cord-254492-42d77vxf	361	46	is	be	VBZ
cord-254492-42d77vxf	361	47	required	require	VBN
cord-254492-42d77vxf	361	48	for	for	IN
cord-254492-42d77vxf	361	49	activation	activation	NN
cord-254492-42d77vxf	361	50	of	of	IN
cord-254492-42d77vxf	361	51	JNK	JNK	NNP
cord-254492-42d77vxf	361	52	but	but	CC
cord-254492-42d77vxf	361	53	not	not	RB
cord-254492-42d77vxf	361	54	of	of	IN
cord-254492-42d77vxf	361	55	p38	p38	CD
cord-254492-42d77vxf	361	56	or	or	CC
cord-254492-42d77vxf	361	57	NF	nf	NN
cord-254492-42d77vxf	361	58	-	-	HYPH
cord-254492-42d77vxf	361	59	κB	κB	NNP
cord-254492-42d77vxf	362	1	Interferon	interferon	NN
cord-254492-42d77vxf	362	2	-	-	HYPH
cord-254492-42d77vxf	362	3	beta	beta	NN
cord-254492-42d77vxf	362	4	induces	induce	VBZ
cord-254492-42d77vxf	362	5	distinct	distinct	JJ
cord-254492-42d77vxf	362	6	gene	gene	NN
cord-254492-42d77vxf	362	7	expression	expression	NN
cord-254492-42d77vxf	362	8	response	response	NN
cord-254492-42d77vxf	362	9	patterns	pattern	NNS
cord-254492-42d77vxf	362	10	in	in	IN
cord-254492-42d77vxf	362	11	human	human	JJ
cord-254492-42d77vxf	362	12	monocytes	monocyte	NNS
cord-254492-42d77vxf	362	13	versus	versus	IN
cord-254492-42d77vxf	362	14	T	t	NN
cord-254492-42d77vxf	362	15	cells	cell	NNS
cord-254492-42d77vxf	363	1	The	the	DT
cord-254492-42d77vxf	363	2	E3	e3	NN
cord-254492-42d77vxf	363	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	363	4	ligase	ligase	NN
cord-254492-42d77vxf	363	5	Ro52	ro52	NN
cord-254492-42d77vxf	363	6	negatively	negatively	RB
cord-254492-42d77vxf	363	7	regulates	regulate	VBZ
cord-254492-42d77vxf	363	8	IFN	IFN	NNP
cord-254492-42d77vxf	363	9	-	-	HYPH
cord-254492-42d77vxf	363	10	β	β	NNP
cord-254492-42d77vxf	363	11	production	production	NN
cord-254492-42d77vxf	363	12	post	post	JJ
cord-254492-42d77vxf	363	13	-	-	JJ
cord-254492-42d77vxf	363	14	pathogen	pathogen	NN
cord-254492-42d77vxf	363	15	recognition	recognition	NN
cord-254492-42d77vxf	363	16	by	by	IN
cord-254492-42d77vxf	363	17	polyubiquitin	polyubiquitin	NNS
cord-254492-42d77vxf	363	18	-	-	HYPH
cord-254492-42d77vxf	363	19	mediated	mediate	VBN
cord-254492-42d77vxf	363	20	degradation	degradation	NN
cord-254492-42d77vxf	363	21	of	of	IN
cord-254492-42d77vxf	363	22	IRF3	IRF3	NNP
cord-254492-42d77vxf	363	23	Self	Self	NNP
cord-254492-42d77vxf	363	24	protection	protection	NN
cord-254492-42d77vxf	363	25	from	from	IN
cord-254492-42d77vxf	363	26	anti	anti	JJ
cord-254492-42d77vxf	363	27	-	-	JJ
cord-254492-42d77vxf	363	28	viral	viral	JJ
cord-254492-42d77vxf	363	29	responses	response	NNS
cord-254492-42d77vxf	363	30	-	-	:
cord-254492-42d77vxf	363	31	Ro52	ro52	NN
cord-254492-42d77vxf	363	32	promotes	promote	VBZ
cord-254492-42d77vxf	363	33	degradation	degradation	NN
cord-254492-42d77vxf	363	34	of	of	IN
cord-254492-42d77vxf	363	35	the	the	DT
cord-254492-42d77vxf	363	36	transcription	transcription	NN
cord-254492-42d77vxf	363	37	factor	factor	NN
cord-254492-42d77vxf	363	38	IRF7	IRF7	NNP
cord-254492-42d77vxf	363	39	downstream	downstream	NN
cord-254492-42d77vxf	363	40	of	of	IN
cord-254492-42d77vxf	363	41	the	the	DT
cord-254492-42d77vxf	363	42	viral	viral	JJ
cord-254492-42d77vxf	363	43	Toll	Toll	NNP
cord-254492-42d77vxf	363	44	-	-	HYPH
cord-254492-42d77vxf	363	45	Like	like	JJ
cord-254492-42d77vxf	363	46	receptors	receptor	NNS
cord-254492-42d77vxf	364	1	The	the	DT
cord-254492-42d77vxf	364	2	ubiquitinediting	ubiquitinedite	VBG
cord-254492-42d77vxf	364	3	enzyme	enzyme	NN
cord-254492-42d77vxf	364	4	A20	A20	NNP
cord-254492-42d77vxf	364	5	restricts	restrict	VBZ
cord-254492-42d77vxf	364	6	nucleotide	nucleotide	NN
cord-254492-42d77vxf	364	7	-	-	HYPH
cord-254492-42d77vxf	364	8	binding	bind	VBG
cord-254492-42d77vxf	364	9	oligomerization	oligomerization	NN
cord-254492-42d77vxf	364	10	domain	domain	NN
cord-254492-42d77vxf	364	11	containing	contain	VBG
cord-254492-42d77vxf	364	12	2-triggered	2-triggered	CD
cord-254492-42d77vxf	364	13	signals	signal	NNS
cord-254492-42d77vxf	364	14	Linear	linear	JJ
cord-254492-42d77vxf	364	15	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	364	16	assembly	assembly	NN
cord-254492-42d77vxf	364	17	complex	complex	NN
cord-254492-42d77vxf	364	18	negatively	negatively	RB
cord-254492-42d77vxf	364	19	regulates	regulate	VBZ
cord-254492-42d77vxf	364	20	RIG	RIG	NNP
cord-254492-42d77vxf	364	21	-	-	HYPH
cord-254492-42d77vxf	364	22	Iand	Iand	NNP
cord-254492-42d77vxf	364	23	TRIM25-mediated	trim25-mediated	JJ
cord-254492-42d77vxf	364	24	type	type	NN
cord-254492-42d77vxf	365	1	I	-PRON-	PRP
cord-254492-42d77vxf	366	1	interferon	interferon	NNP
cord-254492-42d77vxf	366	2	induction	induction	NN
cord-254492-42d77vxf	366	3	Inhibition	Inhibition	NNP
cord-254492-42d77vxf	366	4	of	of	IN
cord-254492-42d77vxf	366	5	RIG	rig	NN
cord-254492-42d77vxf	366	6	-	-	HYPH
cord-254492-42d77vxf	366	7	I	i	NN
cord-254492-42d77vxf	366	8	-	-	HYPH
cord-254492-42d77vxf	366	9	mediated	mediate	VBN
cord-254492-42d77vxf	366	10	signaling	signaling	NN
cord-254492-42d77vxf	366	11	by	by	IN
cord-254492-42d77vxf	366	12	Kaposi	Kaposi	NNP
cord-254492-42d77vxf	366	13	's	's	POS
cord-254492-42d77vxf	366	14	sarcoma	sarcoma	NN
cord-254492-42d77vxf	366	15	-	-	HYPH
cord-254492-42d77vxf	366	16	associated	associate	VBN
cord-254492-42d77vxf	366	17	herpesvirus	herpesvirus	NN
cord-254492-42d77vxf	366	18	-	-	HYPH
cord-254492-42d77vxf	366	19	encoded	encode	VBN
cord-254492-42d77vxf	366	20	deubiquitinase	deubiquitinase	NN
cord-254492-42d77vxf	366	21	ORF64	ORF64	VBN
cord-254492-42d77vxf	366	22	STI	STI	NNP
cord-254492-42d77vxf	366	23	NG	NG	NNP
cord-254492-42d77vxf	366	24	is	be	VBZ
cord-254492-42d77vxf	366	25	an	an	DT
cord-254492-42d77vxf	366	26	endoplasmic	endoplasmic	NN
cord-254492-42d77vxf	366	27	reticulum	reticulum	NN
cord-254492-42d77vxf	366	28	adaptor	adaptor	NN
cord-254492-42d77vxf	366	29	that	that	WDT
cord-254492-42d77vxf	366	30	facilitates	facilitate	VBZ
cord-254492-42d77vxf	366	31	innate	innate	JJ
cord-254492-42d77vxf	366	32	immune	immune	JJ
cord-254492-42d77vxf	366	33	signalling	signal	VBG
cord-254492-42d77vxf	366	34	Toll	toll	NN
cord-254492-42d77vxf	366	35	-	-	HYPH
cord-254492-42d77vxf	366	36	like	like	JJ
cord-254492-42d77vxf	366	37	receptor	receptor	NN
cord-254492-42d77vxf	366	38	3-mediated	3-mediated	CD
cord-254492-42d77vxf	366	39	activation	activation	NN
cord-254492-42d77vxf	366	40	of	of	IN
cord-254492-42d77vxf	366	41	NF	nf	NN
cord-254492-42d77vxf	366	42	-	-	HYPH
cord-254492-42d77vxf	366	43	κB	κB	NNP
cord-254492-42d77vxf	366	44	and	and	CC
cord-254492-42d77vxf	366	45	IRF3	IRF3	NNP
cord-254492-42d77vxf	367	1	diverges	diverge	VBZ
cord-254492-42d77vxf	367	2	at	at	IN
cord-254492-42d77vxf	367	3	Toll	Toll	NNP
cord-254492-42d77vxf	367	4	-	-	HYPH
cord-254492-42d77vxf	367	5	IL-1	IL-1	NNP
cord-254492-42d77vxf	367	6	receptor	receptor	NN
cord-254492-42d77vxf	367	7	domaincontaining	domaincontaining	NN
cord-254492-42d77vxf	367	8	adapter	adapter	NN
cord-254492-42d77vxf	367	9	inducing	induce	VBG
cord-254492-42d77vxf	367	10	IFN	IFN	NNP
cord-254492-42d77vxf	367	11	-	-	HYPH
cord-254492-42d77vxf	367	12	β	β	NNP
cord-254492-42d77vxf	368	1	The	the	DT
cord-254492-42d77vxf	368	2	kinase	kinase	NN
cord-254492-42d77vxf	368	3	MST4	MST4	NNP
cord-254492-42d77vxf	368	4	limits	limit	VBZ
cord-254492-42d77vxf	368	5	inflammatory	inflammatory	JJ
cord-254492-42d77vxf	368	6	responses	response	NNS
cord-254492-42d77vxf	368	7	through	through	IN
cord-254492-42d77vxf	368	8	direct	direct	JJ
cord-254492-42d77vxf	368	9	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	368	10	of	of	IN
cord-254492-42d77vxf	368	11	the	the	DT
cord-254492-42d77vxf	368	12	adaptor	adaptor	NN
cord-254492-42d77vxf	368	13	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	368	14	Activation	Activation	NNP
cord-254492-42d77vxf	368	15	of	of	IN
cord-254492-42d77vxf	368	16	nucleotide	nucleotide	JJ
cord-254492-42d77vxf	368	17	oligomerization	oligomerization	NN
cord-254492-42d77vxf	368	18	domain	domain	NN
cord-254492-42d77vxf	368	19	2	2	CD
cord-254492-42d77vxf	368	20	(	(	-LRB-
cord-254492-42d77vxf	368	21	NOD2	NOD2	NNP
cord-254492-42d77vxf	368	22	)	)	-RRB-
cord-254492-42d77vxf	368	23	by	by	IN
cord-254492-42d77vxf	368	24	human	human	JJ
cord-254492-42d77vxf	368	25	cytomegalovirus	cytomegalovirus	NN
cord-254492-42d77vxf	368	26	initiates	initiate	VBZ
cord-254492-42d77vxf	368	27	innate	innate	JJ
cord-254492-42d77vxf	368	28	immune	immune	JJ
cord-254492-42d77vxf	368	29	responses	response	NNS
cord-254492-42d77vxf	368	30	and	and	CC
cord-254492-42d77vxf	368	31	restricts	restrict	VBZ
cord-254492-42d77vxf	368	32	virus	virus	NN
cord-254492-42d77vxf	368	33	replication	replication	NN
cord-254492-42d77vxf	368	34	Interferon	Interferon	NNP
cord-254492-42d77vxf	368	35	-	-	HYPH
cord-254492-42d77vxf	368	36	α	α	NN
cord-254492-42d77vxf	368	37	induction	induction	NN
cord-254492-42d77vxf	368	38	through	through	IN
cord-254492-42d77vxf	368	39	Toll	Toll	NNP
cord-254492-42d77vxf	368	40	-	-	HYPH
cord-254492-42d77vxf	368	41	like	like	JJ
cord-254492-42d77vxf	368	42	receptors	receptor	NNS
cord-254492-42d77vxf	368	43	involves	involve	VBZ
cord-254492-42d77vxf	368	44	a	a	DT
cord-254492-42d77vxf	368	45	direct	direct	JJ
cord-254492-42d77vxf	368	46	interaction	interaction	NN
cord-254492-42d77vxf	368	47	of	of	IN
cord-254492-42d77vxf	368	48	IRF7	IRF7	NNP
cord-254492-42d77vxf	368	49	with	with	IN
cord-254492-42d77vxf	368	50	MyD88	MyD88	NNP
cord-254492-42d77vxf	368	51	and	and	CC
cord-254492-42d77vxf	368	52	TRAF6	traf6	NN
cord-254492-42d77vxf	368	53	DUBA	DUBA	NNS
cord-254492-42d77vxf	368	54	:	:	:
cord-254492-42d77vxf	368	55	a	a	DT
cord-254492-42d77vxf	368	56	deubiquitinase	deubiquitinase	NN
cord-254492-42d77vxf	368	57	that	that	WDT
cord-254492-42d77vxf	368	58	regulates	regulate	VBZ
cord-254492-42d77vxf	368	59	type	type	NN
cord-254492-42d77vxf	369	1	I	-PRON-	PRP
cord-254492-42d77vxf	369	2	interferon	interferon	VBD
cord-254492-42d77vxf	369	3	production	production	NN
cord-254492-42d77vxf	370	1	The	the	DT
cord-254492-42d77vxf	370	2	nucleotidebinding	nucleotidebinde	VBG
cord-254492-42d77vxf	370	3	oligomerization	oligomerization	NN
cord-254492-42d77vxf	370	4	domain	domain	NN
cord-254492-42d77vxf	370	5	-	-	HYPH
cord-254492-42d77vxf	370	6	like	like	JJ
cord-254492-42d77vxf	370	7	receptor	receptor	NN
cord-254492-42d77vxf	370	8	NLRC5	nlrc5	NN
cord-254492-42d77vxf	370	9	is	be	VBZ
cord-254492-42d77vxf	370	10	involved	involve	VBN
cord-254492-42d77vxf	370	11	in	in	IN
cord-254492-42d77vxf	370	12	IFN	IFN	NNP
cord-254492-42d77vxf	370	13	-	-	HYPH
cord-254492-42d77vxf	370	14	dependent	dependent	JJ
cord-254492-42d77vxf	370	15	antiviral	antiviral	JJ
cord-254492-42d77vxf	370	16	immune	immune	JJ
cord-254492-42d77vxf	370	17	responses	response	NNS
cord-254492-42d77vxf	371	1	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	371	2	deficiency	deficiency	NN
cord-254492-42d77vxf	371	3	does	do	VBZ
cord-254492-42d77vxf	371	4	not	not	RB
cord-254492-42d77vxf	371	5	influence	influence	VB
cord-254492-42d77vxf	371	6	cytokine	cytokine	NN
cord-254492-42d77vxf	371	7	induction	induction	NN
cord-254492-42d77vxf	371	8	by	by	IN
cord-254492-42d77vxf	371	9	virus	virus	NN
cord-254492-42d77vxf	371	10	and	and	CC
cord-254492-42d77vxf	371	11	bacteria	bacteria	NNS
cord-254492-42d77vxf	371	12	infections	infection	NNS
cord-254492-42d77vxf	371	13	Site	site	NN
cord-254492-42d77vxf	371	14	-	-	HYPH
cord-254492-42d77vxf	371	15	specific	specific	JJ
cord-254492-42d77vxf	371	16	Lys-63-linked	Lys-63-linked	NNP
cord-254492-42d77vxf	371	17	tumor	tumor	NN
cord-254492-42d77vxf	371	18	necrosis	necrosis	NN
cord-254492-42d77vxf	371	19	factor	factor	NN
cord-254492-42d77vxf	371	20	receptorassociated	receptorassociate	VBD
cord-254492-42d77vxf	371	21	factor	factor	NN
cord-254492-42d77vxf	371	22	6	6	CD
cord-254492-42d77vxf	371	23	auto	auto	NN
cord-254492-42d77vxf	371	24	-	-	HYPH
cord-254492-42d77vxf	371	25	ubiquitination	ubiquitination	JJ
cord-254492-42d77vxf	372	1	is	be	VBZ
cord-254492-42d77vxf	372	2	a	a	DT
cord-254492-42d77vxf	372	3	critical	critical	JJ
cord-254492-42d77vxf	372	4	determinant	determinant	NN
cord-254492-42d77vxf	372	5	of	of	IN
cord-254492-42d77vxf	372	6	IκB	iκb	NN
cord-254492-42d77vxf	372	7	kinase	kinase	NN
cord-254492-42d77vxf	372	8	activation	activation	NN
cord-254492-42d77vxf	372	9	Regulation	regulation	NN
cord-254492-42d77vxf	372	10	of	of	IN
cord-254492-42d77vxf	372	11	MDA5-MAVS	MDA5-MAVS	NNP
cord-254492-42d77vxf	372	12	antiviral	antiviral	JJ
cord-254492-42d77vxf	372	13	signaling	signal	VBG
cord-254492-42d77vxf	372	14	axis	axis	NN
cord-254492-42d77vxf	372	15	by	by	IN
cord-254492-42d77vxf	372	16	TRIM25	trim25	NN
cord-254492-42d77vxf	372	17	through	through	IN
cord-254492-42d77vxf	372	18	TRAF6-mediated	traf6-mediated	CD
cord-254492-42d77vxf	372	19	NF	NF	NNP
cord-254492-42d77vxf	372	20	-	-	HYPH
cord-254492-42d77vxf	372	21	κB	κb	CD
cord-254492-42d77vxf	372	22	activation	activation	NN
cord-254492-42d77vxf	372	23	Smad6-specific	Smad6-specific	NNP
cord-254492-42d77vxf	372	24	recruitment	recruitment	NN
cord-254492-42d77vxf	372	25	of	of	IN
cord-254492-42d77vxf	372	26	Smurf	Smurf	NNP
cord-254492-42d77vxf	372	27	E3	E3	NNP
cord-254492-42d77vxf	372	28	ligases	ligase	NNS
cord-254492-42d77vxf	373	1	mediates	mediate	VBZ
cord-254492-42d77vxf	373	2	TGF	TGF	NNP
cord-254492-42d77vxf	373	3	-	-	HYPH
cord-254492-42d77vxf	373	4	β1-induced	β1-induce	VBN
cord-254492-42d77vxf	373	5	degradation	degradation	NN
cord-254492-42d77vxf	373	6	of	of	IN
cord-254492-42d77vxf	373	7	MyD88	MyD88	NNS
cord-254492-42d77vxf	373	8	in	in	IN
cord-254492-42d77vxf	373	9	TLR4	TLR4	NNP
cord-254492-42d77vxf	373	10	signalling	signal	VBG
cord-254492-42d77vxf	373	11	FoxO1	FoxO1	NNP
cord-254492-42d77vxf	373	12	negatively	negatively	RB
cord-254492-42d77vxf	373	13	regulates	regulate	VBZ
cord-254492-42d77vxf	373	14	cellular	cellular	JJ
cord-254492-42d77vxf	373	15	antiviral	antiviral	JJ
cord-254492-42d77vxf	373	16	response	response	NN
cord-254492-42d77vxf	373	17	by	by	IN
cord-254492-42d77vxf	373	18	promoting	promote	VBG
cord-254492-42d77vxf	373	19	degradation	degradation	NN
cord-254492-42d77vxf	373	20	of	of	IN
cord-254492-42d77vxf	374	1	IRF3	IRF3	NNP
cord-254492-42d77vxf	374	2	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	374	3	ligase	ligase	NN
cord-254492-42d77vxf	374	4	Smurf1	Smurf1	NNP
cord-254492-42d77vxf	374	5	targets	target	VBZ
cord-254492-42d77vxf	374	6	TRAF	TRAF	NNP
cord-254492-42d77vxf	374	7	family	family	NN
cord-254492-42d77vxf	374	8	proteins	protein	VBZ
cord-254492-42d77vxf	374	9	for	for	IN
cord-254492-42d77vxf	374	10	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	374	11	and	and	CC
cord-254492-42d77vxf	374	12	degradation	degradation	NN
cord-254492-42d77vxf	374	13	Regulation	regulation	NN
cord-254492-42d77vxf	374	14	of	of	IN
cord-254492-42d77vxf	375	1	virus	virus	NN
cord-254492-42d77vxf	375	2	-	-	HYPH
cord-254492-42d77vxf	375	3	triggered	trigger	VBN
cord-254492-42d77vxf	375	4	signaling	signaling	NN
cord-254492-42d77vxf	375	5	by	by	IN
cord-254492-42d77vxf	376	1	OTUB1-and	OTUB1-and	NNP
cord-254492-42d77vxf	376	2	OTUB2-mediated	otub2-mediated	JJ
cord-254492-42d77vxf	376	3	deubiquitination	deubiquitination	NN
cord-254492-42d77vxf	376	4	of	of	IN
cord-254492-42d77vxf	376	5	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	376	6	and	and	CC
cord-254492-42d77vxf	376	7	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	376	8	Genome	Genome	NNP
cord-254492-42d77vxf	376	9	-	-	HYPH
cord-254492-42d77vxf	376	10	wide	wide	JJ
cord-254492-42d77vxf	376	11	and	and	CC
cord-254492-42d77vxf	376	12	functional	functional	JJ
cord-254492-42d77vxf	376	13	annotation	annotation	NN
cord-254492-42d77vxf	376	14	of	of	IN
cord-254492-42d77vxf	376	15	human	human	JJ
cord-254492-42d77vxf	376	16	E3	e3	NN
cord-254492-42d77vxf	376	17	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	376	18	ligases	ligase	NNS
cord-254492-42d77vxf	376	19	identifies	identify	VBZ
cord-254492-42d77vxf	376	20	MUL	MUL	NNP
cord-254492-42d77vxf	376	21	AN	AN	NNP
cord-254492-42d77vxf	376	22	,	,	,
cord-254492-42d77vxf	376	23	a	a	DT
cord-254492-42d77vxf	376	24	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	376	25	E3	e3	NN
cord-254492-42d77vxf	376	26	that	that	WDT
cord-254492-42d77vxf	376	27	regulates	regulate	VBZ
cord-254492-42d77vxf	376	28	the	the	DT
cord-254492-42d77vxf	376	29	organelle	organelle	NN
cord-254492-42d77vxf	376	30	's	's	POS
cord-254492-42d77vxf	376	31	dynamics	dynamic	NNS
cord-254492-42d77vxf	376	32	and	and	CC
cord-254492-42d77vxf	376	33	signaling	signal	VBG
cord-254492-42d77vxf	376	34	Tripartite	tripartite	JJ
cord-254492-42d77vxf	376	35	motif	motif	NN
cord-254492-42d77vxf	376	36	-	-	HYPH
cord-254492-42d77vxf	376	37	containing	contain	VBG
cord-254492-42d77vxf	376	38	protein	protein	NN
cord-254492-42d77vxf	376	39	28	28	CD
cord-254492-42d77vxf	376	40	is	be	VBZ
cord-254492-42d77vxf	376	41	a	a	DT
cord-254492-42d77vxf	376	42	small	small	JJ
cord-254492-42d77vxf	376	43	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	376	44	-	-	HYPH
cord-254492-42d77vxf	376	45	related	relate	VBN
cord-254492-42d77vxf	376	46	modifier	modifier	NN
cord-254492-42d77vxf	376	47	E3	e3	NN
cord-254492-42d77vxf	376	48	ligase	ligase	NN
cord-254492-42d77vxf	376	49	and	and	CC
cord-254492-42d77vxf	376	50	negative	negative	JJ
cord-254492-42d77vxf	376	51	regulator	regulator	NN
cord-254492-42d77vxf	376	52	of	of	IN
cord-254492-42d77vxf	376	53	IFN	IFN	NNP
cord-254492-42d77vxf	376	54	regulatory	regulatory	JJ
cord-254492-42d77vxf	376	55	factor	factor	NN
cord-254492-42d77vxf	377	1	7	7	CD
cord-254492-42d77vxf	377	2	Virus	virus	NN
cord-254492-42d77vxf	377	3	-	-	HYPH
cord-254492-42d77vxf	377	4	dependent	dependent	JJ
cord-254492-42d77vxf	377	5	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	377	6	of	of	IN
cord-254492-42d77vxf	377	7	the	the	DT
cord-254492-42d77vxf	377	8	IRF-3	IRF-3	NNP
cord-254492-42d77vxf	377	9	transcription	transcription	NN
cord-254492-42d77vxf	377	10	factor	factor	NN
cord-254492-42d77vxf	377	11	regulates	regulate	VBZ
cord-254492-42d77vxf	377	12	nuclear	nuclear	JJ
cord-254492-42d77vxf	377	13	translocation	translocation	NN
cord-254492-42d77vxf	377	14	,	,	,
cord-254492-42d77vxf	377	15	transactivation	transactivation	NN
cord-254492-42d77vxf	377	16	potential	potential	NN
cord-254492-42d77vxf	377	17	,	,	,
cord-254492-42d77vxf	377	18	and	and	CC
cord-254492-42d77vxf	377	19	proteasome	proteasome	VBN
cord-254492-42d77vxf	377	20	-	-	HYPH
cord-254492-42d77vxf	377	21	mediated	mediate	VBN
cord-254492-42d77vxf	377	22	degradation	degradation	NN
cord-254492-42d77vxf	377	23	Nucleotide	Nucleotide	NNP
cord-254492-42d77vxf	377	24	oligomerization	oligomerization	NN
cord-254492-42d77vxf	377	25	and	and	CC
cord-254492-42d77vxf	377	26	binding	bind	VBG
cord-254492-42d77vxf	377	27	domain	domain	NN
cord-254492-42d77vxf	377	28	2-dependent	2-dependent	CD
cord-254492-42d77vxf	377	29	dendritic	dendritic	JJ
cord-254492-42d77vxf	377	30	cell	cell	NN
cord-254492-42d77vxf	377	31	activation	activation	NN
cord-254492-42d77vxf	377	32	is	be	VBZ
cord-254492-42d77vxf	377	33	necessary	necessary	JJ
cord-254492-42d77vxf	377	34	for	for	IN
cord-254492-42d77vxf	377	35	innate	innate	JJ
cord-254492-42d77vxf	377	36	immunity	immunity	NN
cord-254492-42d77vxf	377	37	and	and	CC
cord-254492-42d77vxf	377	38	optimal	optimal	JJ
cord-254492-42d77vxf	377	39	CD8	CD8	NNS
cord-254492-42d77vxf	377	40	+	+	CC
cord-254492-42d77vxf	377	41	T	T	NNP
cord-254492-42d77vxf	377	42	Cell	cell	NN
cord-254492-42d77vxf	377	43	responses	response	NNS
cord-254492-42d77vxf	377	44	to	to	TO
cord-254492-42d77vxf	377	45	influenza	influenza	VB
cord-254492-42d77vxf	377	46	A	a	DT
cord-254492-42d77vxf	377	47	virus	virus	NN
cord-254492-42d77vxf	377	48	infection	infection	NN
cord-254492-42d77vxf	377	49	Virus	virus	NN
cord-254492-42d77vxf	377	50	-	-	HYPH
cord-254492-42d77vxf	377	51	triggered	trigger	VBN
cord-254492-42d77vxf	377	52	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	377	53	of	of	IN
cord-254492-42d77vxf	377	54	TRAF3/6	TRAF3/6	NNP
cord-254492-42d77vxf	378	1	by	by	IN
cord-254492-42d77vxf	378	2	cIAP1/2	cIAP1/2	NNP
cord-254492-42d77vxf	378	3	is	be	VBZ
cord-254492-42d77vxf	378	4	essential	essential	JJ
cord-254492-42d77vxf	378	5	for	for	IN
cord-254492-42d77vxf	378	6	induction	induction	NN
cord-254492-42d77vxf	378	7	of	of	IN
cord-254492-42d77vxf	378	8	interferon	interferon	NN
cord-254492-42d77vxf	378	9	-	-	HYPH
cord-254492-42d77vxf	378	10	β	β	NN
cord-254492-42d77vxf	378	11	(	(	-LRB-
cord-254492-42d77vxf	378	12	IFN	IFN	NNP
cord-254492-42d77vxf	378	13	-	-	HYPH
cord-254492-42d77vxf	378	14	β	β	NNP
cord-254492-42d77vxf	378	15	)	)	-RRB-
cord-254492-42d77vxf	378	16	and	and	CC
cord-254492-42d77vxf	378	17	cellular	cellular	JJ
cord-254492-42d77vxf	378	18	antiviral	antiviral	JJ
cord-254492-42d77vxf	378	19	response	response	NN
cord-254492-42d77vxf	378	20	IκB	IκB	NNP
cord-254492-42d77vxf	378	21	kinase	kinase	NN
cord-254492-42d77vxf	378	22	α	α	NN
cord-254492-42d77vxf	378	23	phosphorylation	phosphorylation	NN
cord-254492-42d77vxf	378	24	of	of	IN
cord-254492-42d77vxf	378	25	TRAF4	traf4	NN
cord-254492-42d77vxf	379	1	downregulates	downregulates	NNP
cord-254492-42d77vxf	379	2	innate	innate	JJ
cord-254492-42d77vxf	379	3	immune	immune	NN
cord-254492-42d77vxf	379	4	signaling	signal	VBG
cord-254492-42d77vxf	379	5	Putative	putative	JJ
cord-254492-42d77vxf	379	6	E3	e3	NN
cord-254492-42d77vxf	379	7	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	379	8	ligase	ligase	NN
cord-254492-42d77vxf	379	9	of	of	IN
cord-254492-42d77vxf	379	10	human	human	JJ
cord-254492-42d77vxf	379	11	rotavirus	rotavirus	NN
cord-254492-42d77vxf	380	1	inhibits	inhibit	VBZ
cord-254492-42d77vxf	380	2	NF	NF	NNP
cord-254492-42d77vxf	380	3	-	-	HYPH
cord-254492-42d77vxf	380	4	κB	κb	CD
cord-254492-42d77vxf	380	5	activation	activation	NN
cord-254492-42d77vxf	380	6	by	by	IN
cord-254492-42d77vxf	380	7	using	use	VBG
cord-254492-42d77vxf	380	8	molecular	molecular	JJ
cord-254492-42d77vxf	380	9	mimicry	mimicry	NN
cord-254492-42d77vxf	380	10	to	to	TO
cord-254492-42d77vxf	380	11	target	target	VB
cord-254492-42d77vxf	380	12	β	β	NN
cord-254492-42d77vxf	380	13	-	-	HYPH
cord-254492-42d77vxf	380	14	TrCP	TrCP	NNP
cord-254492-42d77vxf	381	1	The	the	DT
cord-254492-42d77vxf	381	2	E3	e3	NN
cord-254492-42d77vxf	381	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	381	4	ligase	ligase	NN
cord-254492-42d77vxf	381	5	Triad3A	Triad3A	NNP
cord-254492-42d77vxf	381	6	negatively	negatively	RB
cord-254492-42d77vxf	381	7	regulates	regulate	VBZ
cord-254492-42d77vxf	381	8	the	the	DT
cord-254492-42d77vxf	381	9	RIG	rig	NN
cord-254492-42d77vxf	381	10	-	-	HYPH
cord-254492-42d77vxf	381	11	I	I	NNP
cord-254492-42d77vxf	381	12	/	/	SYM
cord-254492-42d77vxf	381	13	MAVS	MAVS	NNP
cord-254492-42d77vxf	381	14	signaling	signal	VBG
cord-254492-42d77vxf	381	15	pathway	pathway	NN
cord-254492-42d77vxf	381	16	by	by	IN
cord-254492-42d77vxf	381	17	targeting	target	VBG
cord-254492-42d77vxf	381	18	TRAF3	traf3	NN
cord-254492-42d77vxf	381	19	for	for	IN
cord-254492-42d77vxf	381	20	degradation	degradation	NN
cord-254492-42d77vxf	381	21	A	a	DT
cord-254492-42d77vxf	381	22	role	role	NN
cord-254492-42d77vxf	381	23	for	for	IN
cord-254492-42d77vxf	381	24	the	the	DT
cord-254492-42d77vxf	381	25	human	human	JJ
cord-254492-42d77vxf	381	26	nucleotide	nucleotide	NN
cord-254492-42d77vxf	381	27	-	-	HYPH
cord-254492-42d77vxf	381	28	binding	bind	VBG
cord-254492-42d77vxf	381	29	domain	domain	NN
cord-254492-42d77vxf	381	30	,	,	,
cord-254492-42d77vxf	381	31	leucine	leucine	NN
cord-254492-42d77vxf	381	32	-	-	HYPH
cord-254492-42d77vxf	381	33	rich	rich	JJ
cord-254492-42d77vxf	381	34	repeat	repeat	NN
cord-254492-42d77vxf	381	35	-	-	HYPH
cord-254492-42d77vxf	381	36	containing	contain	VBG
cord-254492-42d77vxf	381	37	family	family	NN
cord-254492-42d77vxf	381	38	member	member	NN
cord-254492-42d77vxf	381	39	NLRC5	nlrc5	JJ
cord-254492-42d77vxf	381	40	in	in	IN
cord-254492-42d77vxf	381	41	antiviral	antiviral	JJ
cord-254492-42d77vxf	381	42	responses	response	NNS
cord-254492-42d77vxf	381	43	Meta	Meta	NNP
cord-254492-42d77vxf	381	44	-	-	HYPH
cord-254492-42d77vxf	381	45	analysis	analysis	NN
cord-254492-42d77vxf	381	46	of	of	IN
cord-254492-42d77vxf	381	47	patients	patient	NNS
cord-254492-42d77vxf	381	48	with	with	IN
cord-254492-42d77vxf	381	49	hepatitis	hepatitis	NN
cord-254492-42d77vxf	381	50	C	C	NNP
cord-254492-42d77vxf	381	51	virus	virus	NN
cord-254492-42d77vxf	381	52	genotype	genotype	NN
cord-254492-42d77vxf	381	53	6	6	CD
cord-254492-42d77vxf	381	54	:	:	:
cord-254492-42d77vxf	381	55	48	48	CD
cord-254492-42d77vxf	381	56	weeks	week	NNS
cord-254492-42d77vxf	381	57	with	with	IN
cord-254492-42d77vxf	381	58	pegylated	pegylated	JJ
cord-254492-42d77vxf	381	59	interferon	interferon	NN
cord-254492-42d77vxf	381	60	and	and	CC
cord-254492-42d77vxf	381	61	ribavirin	ribavirin	NN
cord-254492-42d77vxf	381	62	is	be	VBZ
cord-254492-42d77vxf	381	63	superior	superior	JJ
cord-254492-42d77vxf	381	64	to	to	IN
cord-254492-42d77vxf	381	65	24	24	CD
cord-254492-42d77vxf	381	66	weeks	week	NNS
cord-254492-42d77vxf	382	1	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	383	1	and	and	CC
cord-254492-42d77vxf	383	2	the	the	DT
cord-254492-42d77vxf	383	3	three	three	CD
cord-254492-42d77vxf	383	4	C	c	NN
cord-254492-42d77vxf	383	5	-	-	HYPH
cord-254492-42d77vxf	383	6	terminal	terminal	NN
cord-254492-42d77vxf	383	7	lysine	lysine	NN
cord-254492-42d77vxf	383	8	sites	site	NNS
cord-254492-42d77vxf	383	9	on	on	IN
cord-254492-42d77vxf	383	10	IRF7	IRF7	NNP
cord-254492-42d77vxf	383	11	are	be	VBP
cord-254492-42d77vxf	383	12	required	require	VBN
cord-254492-42d77vxf	383	13	for	for	IN
cord-254492-42d77vxf	383	14	its	-PRON-	PRP$
cord-254492-42d77vxf	383	15	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	383	16	-	-	HYPH
cord-254492-42d77vxf	383	17	mediated	mediate	VBN
cord-254492-42d77vxf	383	18	activation	activation	NN
cord-254492-42d77vxf	383	19	by	by	IN
cord-254492-42d77vxf	383	20	the	the	DT
cord-254492-42d77vxf	383	21	tumor	tumor	NN
cord-254492-42d77vxf	383	22	necrosis	necrosis	NN
cord-254492-42d77vxf	383	23	factor	factor	NN
cord-254492-42d77vxf	383	24	receptor	receptor	NN
cord-254492-42d77vxf	383	25	family	family	NN
cord-254492-42d77vxf	383	26	member	member	NN
cord-254492-42d77vxf	383	27	latent	latent	NN
cord-254492-42d77vxf	383	28	membrane	membrane	NN
cord-254492-42d77vxf	383	29	protein	protein	NN
cord-254492-42d77vxf	384	1	1	1	LS
cord-254492-42d77vxf	384	2	A	a	DT
cord-254492-42d77vxf	384	3	protein	protein	NN
cord-254492-42d77vxf	384	4	-	-	HYPH
cord-254492-42d77vxf	384	5	kinase	kinase	NN
cord-254492-42d77vxf	384	6	,	,	,
cord-254492-42d77vxf	384	7	IFN	IFN	NNP
cord-254492-42d77vxf	384	8	-	-	HYPH
cord-254492-42d77vxf	384	9	inducible	inducible	JJ
cord-254492-42d77vxf	384	10	doublestranded	doublestranded	NNP
cord-254492-42d77vxf	384	11	RNA	RNA	NNP
cord-254492-42d77vxf	384	12	dependent	dependent	JJ
cord-254492-42d77vxf	384	13	inhibitor	inhibitor	NN
cord-254492-42d77vxf	384	14	and	and	CC
cord-254492-42d77vxf	384	15	repressor	repressor	NN
cord-254492-42d77vxf	384	16	of	of	IN
cord-254492-42d77vxf	384	17	p58	p58	NNP
cord-254492-42d77vxf	384	18	(	(	-LRB-
cord-254492-42d77vxf	384	19	PRK	PRK	NNP
cord-254492-42d77vxf	384	20	RIR	RIR	NNP
cord-254492-42d77vxf	384	21	)	)	-RRB-
cord-254492-42d77vxf	384	22	enhances	enhance	VBZ
cord-254492-42d77vxf	384	23	type	type	NN
cord-254492-42d77vxf	385	1	I	-PRON-	PRP
cord-254492-42d77vxf	385	2	IFN	IFN	NNP
cord-254492-42d77vxf	385	3	-	-	HYPH
cord-254492-42d77vxf	385	4	mediated	mediate	VBN
cord-254492-42d77vxf	385	5	antiviral	antiviral	JJ
cord-254492-42d77vxf	385	6	response	response	NN
cord-254492-42d77vxf	385	7	through	through	IN
cord-254492-42d77vxf	385	8	the	the	DT
cord-254492-42d77vxf	385	9	stability	stability	NN
cord-254492-42d77vxf	385	10	control	control	NN
cord-254492-42d77vxf	385	11	of	of	IN
cord-254492-42d77vxf	385	12	RIG-	RIG-	NNP
cord-254492-42d77vxf	386	1	I	-PRON-	PRP
cord-254492-42d77vxf	387	1	protein	protein	NNP
cord-254492-42d77vxf	387	2	Inhibition	Inhibition	NNP
cord-254492-42d77vxf	387	3	of	of	IN
cord-254492-42d77vxf	387	4	transcription	transcription	NN
cord-254492-42d77vxf	387	5	of	of	IN
cord-254492-42d77vxf	387	6	herpes	herpes	NNP
cord-254492-42d77vxf	387	7	simplex	simplex	NNP
cord-254492-42d77vxf	387	8	virus	virus	NN
cord-254492-42d77vxf	388	1	immediate	immediate	JJ
cord-254492-42d77vxf	388	2	early	early	JJ
cord-254492-42d77vxf	388	3	genes	gene	NNS
cord-254492-42d77vxf	388	4	in	in	IN
cord-254492-42d77vxf	388	5	interferon	interferon	NN
cord-254492-42d77vxf	388	6	-	-	HYPH
cord-254492-42d77vxf	388	7	treated	treat	VBN
cord-254492-42d77vxf	388	8	human	human	JJ
cord-254492-42d77vxf	388	9	cells	cell	NNS
cord-254492-42d77vxf	388	10	HIV-1	HIV-1	NNP
cord-254492-42d77vxf	388	11	accessory	accessory	NN
cord-254492-42d77vxf	388	12	proteins	protein	NNS
cord-254492-42d77vxf	388	13	VPR	VPR	NNP
cord-254492-42d77vxf	388	14	and	and	CC
cord-254492-42d77vxf	388	15	Vif	Vif	NNP
cord-254492-42d77vxf	388	16	modulate	modulate	VB
cord-254492-42d77vxf	388	17	antiviral	antiviral	JJ
cord-254492-42d77vxf	388	18	response	response	NN
cord-254492-42d77vxf	388	19	by	by	IN
cord-254492-42d77vxf	388	20	targeting	target	VBG
cord-254492-42d77vxf	388	21	IRF-3	IRF-3	NNP
cord-254492-42d77vxf	388	22	for	for	IN
cord-254492-42d77vxf	388	23	degradation	degradation	NN
cord-254492-42d77vxf	389	1	Riplet/	Riplet/	NFP
cord-254492-42d77vxf	389	2	RNF135	RNF135	NNS
cord-254492-42d77vxf	389	3	,	,	,
cord-254492-42d77vxf	389	4	a	a	DT
cord-254492-42d77vxf	389	5	RING	ring	NN
cord-254492-42d77vxf	389	6	finger	finger	NN
cord-254492-42d77vxf	389	7	protein	protein	NN
cord-254492-42d77vxf	389	8	,	,	.
cord-254492-42d77vxf	390	1	ubiquitinates	ubiquitinates	NNP
cord-254492-42d77vxf	390	2	RIG	RIG	NNP
cord-254492-42d77vxf	390	3	-	-	:
cord-254492-42d77vxf	390	4	I	-PRON-	PRP
cord-254492-42d77vxf	390	5	to	to	TO
cord-254492-42d77vxf	390	6	promote	promote	VB
cord-254492-42d77vxf	390	7	interferon	interferon	NN
cord-254492-42d77vxf	390	8	-	-	HYPH
cord-254492-42d77vxf	390	9	β	β	NN
cord-254492-42d77vxf	390	10	induction	induction	NN
cord-254492-42d77vxf	390	11	during	during	IN
cord-254492-42d77vxf	390	12	the	the	DT
cord-254492-42d77vxf	390	13	early	early	JJ
cord-254492-42d77vxf	390	14	phase	phase	NN
cord-254492-42d77vxf	390	15	of	of	IN
cord-254492-42d77vxf	390	16	viral	viral	JJ
cord-254492-42d77vxf	390	17	infection	infection	NN
cord-254492-42d77vxf	391	1	The	the	DT
cord-254492-42d77vxf	391	2	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	391	3	ligase	ligase	NN
cord-254492-42d77vxf	391	4	Riplet	Riplet	NNP
cord-254492-42d77vxf	391	5	is	be	VBZ
cord-254492-42d77vxf	391	6	essential	essential	JJ
cord-254492-42d77vxf	391	7	for	for	IN
cord-254492-42d77vxf	391	8	RIG	rig	NN
cord-254492-42d77vxf	391	9	-	-	HYPH
cord-254492-42d77vxf	391	10	I	i	NN
cord-254492-42d77vxf	391	11	-	-	HYPH
cord-254492-42d77vxf	391	12	dependent	dependent	JJ
cord-254492-42d77vxf	391	13	innate	innate	JJ
cord-254492-42d77vxf	391	14	immune	immune	JJ
cord-254492-42d77vxf	391	15	responses	response	NNS
cord-254492-42d77vxf	391	16	to	to	IN
cord-254492-42d77vxf	391	17	RNA	RNA	NNP
cord-254492-42d77vxf	391	18	virus	virus	NN
cord-254492-42d77vxf	391	19	infection	infection	NN
cord-254492-42d77vxf	391	20	A	a	DT
cord-254492-42d77vxf	391	21	distinct	distinct	JJ
cord-254492-42d77vxf	391	22	role	role	NN
cord-254492-42d77vxf	391	23	of	of	IN
cord-254492-42d77vxf	391	24	Riplet	Riplet	NNP
cord-254492-42d77vxf	391	25	-	-	HYPH
cord-254492-42d77vxf	391	26	mediated	mediate	VBN
cord-254492-42d77vxf	391	27	K63-Linked	k63-linke	VBN
cord-254492-42d77vxf	391	28	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	391	29	of	of	IN
cord-254492-42d77vxf	391	30	the	the	DT
cord-254492-42d77vxf	391	31	RIG	rig	NN
cord-254492-42d77vxf	391	32	-	-	:
cord-254492-42d77vxf	391	33	I	i	NN
cord-254492-42d77vxf	391	34	repressor	repressor	NN
cord-254492-42d77vxf	391	35	domain	domain	NN
cord-254492-42d77vxf	391	36	in	in	IN
cord-254492-42d77vxf	391	37	human	human	JJ
cord-254492-42d77vxf	391	38	antiviral	antiviral	JJ
cord-254492-42d77vxf	391	39	innate	innate	JJ
cord-254492-42d77vxf	391	40	immune	immune	JJ
cord-254492-42d77vxf	391	41	responses	response	NNS
cord-254492-42d77vxf	392	1	Smurf2	Smurf2	NNP
cord-254492-42d77vxf	392	2	negatively	negatively	RB
cord-254492-42d77vxf	392	3	modulates	modulate	VBZ
cord-254492-42d77vxf	392	4	RIG	rig	NN
cord-254492-42d77vxf	392	5	-	-	HYPH
cord-254492-42d77vxf	392	6	I	i	NN
cord-254492-42d77vxf	392	7	-	-	HYPH
cord-254492-42d77vxf	392	8	dependent	dependent	JJ
cord-254492-42d77vxf	392	9	antiviral	antiviral	JJ
cord-254492-42d77vxf	392	10	response	response	NN
cord-254492-42d77vxf	392	11	by	by	IN
cord-254492-42d77vxf	392	12	targeting	target	VBG
cord-254492-42d77vxf	392	13	VISA	VISA	NNP
cord-254492-42d77vxf	392	14	/	/	SYM
cord-254492-42d77vxf	392	15	MAVS	MAVS	NNP
cord-254492-42d77vxf	392	16	for	for	IN
cord-254492-42d77vxf	392	17	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	392	18	and	and	CC
cord-254492-42d77vxf	392	19	degradation	degradation	NN
cord-254492-42d77vxf	392	20	TAX1BP1	TAX1BP1	NNP
cord-254492-42d77vxf	392	21	and	and	CC
cord-254492-42d77vxf	392	22	A20	A20	NNP
cord-254492-42d77vxf	392	23	inhibit	inhibit	VBP
cord-254492-42d77vxf	392	24	antiviral	antiviral	JJ
cord-254492-42d77vxf	392	25	signaling	signal	VBG
cord-254492-42d77vxf	392	26	by	by	IN
cord-254492-42d77vxf	392	27	targeting	target	VBG
cord-254492-42d77vxf	392	28	TBK1-IKKi	TBK1-IKKi	NNP
cord-254492-42d77vxf	392	29	kinases	kinase	NNS
cord-254492-42d77vxf	392	30	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	392	31	-	-	HYPH
cord-254492-42d77vxf	392	32	regulated	regulate	VBN
cord-254492-42d77vxf	392	33	recruitment	recruitment	NN
cord-254492-42d77vxf	392	34	of	of	IN
cord-254492-42d77vxf	392	35	IκB	IκB	NNP
cord-254492-42d77vxf	392	36	kinase	kinase	NNP
cord-254492-42d77vxf	392	37	ε	ε	NNP
cord-254492-42d77vxf	392	38	to	to	IN
cord-254492-42d77vxf	392	39	the	the	DT
cord-254492-42d77vxf	392	40	MAVS	MAVS	NNPS
cord-254492-42d77vxf	393	1	interferon	interferon	NN
cord-254492-42d77vxf	393	2	signaling	signal	VBG
cord-254492-42d77vxf	393	3	adapter	adapter	NN
cord-254492-42d77vxf	394	1	A	a	DT
cord-254492-42d77vxf	394	2	functional	functional	JJ
cord-254492-42d77vxf	394	3	C	c	NN
cord-254492-42d77vxf	394	4	-	-	HYPH
cord-254492-42d77vxf	394	5	terminal	terminal	NN
cord-254492-42d77vxf	394	6	TRAF3-binding	TRAF3-binding	NNP
cord-254492-42d77vxf	394	7	site	site	NN
cord-254492-42d77vxf	394	8	in	in	IN
cord-254492-42d77vxf	394	9	MAVS	MAVS	NNP
cord-254492-42d77vxf	394	10	participates	participate	VBZ
cord-254492-42d77vxf	394	11	in	in	IN
cord-254492-42d77vxf	394	12	positive	positive	JJ
cord-254492-42d77vxf	394	13	and	and	CC
cord-254492-42d77vxf	394	14	negative	negative	JJ
cord-254492-42d77vxf	394	15	regulation	regulation	NN
cord-254492-42d77vxf	394	16	of	of	IN
cord-254492-42d77vxf	394	17	the	the	DT
cord-254492-42d77vxf	394	18	IFN	IFN	NNP
cord-254492-42d77vxf	394	19	antiviral	antiviral	JJ
cord-254492-42d77vxf	394	20	response	response	NN
cord-254492-42d77vxf	394	21	Kinetic	Kinetic	NNP
cord-254492-42d77vxf	394	22	mechanism	mechanism	NN
cord-254492-42d77vxf	394	23	for	for	IN
cord-254492-42d77vxf	394	24	viral	viral	JJ
cord-254492-42d77vxf	394	25	dsRNA	dsrna	JJ
cord-254492-42d77vxf	394	26	length	length	NN
cord-254492-42d77vxf	394	27	discrimination	discrimination	NN
cord-254492-42d77vxf	394	28	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	394	29	in	in	IN
cord-254492-42d77vxf	394	30	antiviral	antiviral	JJ
cord-254492-42d77vxf	394	31	immunity	immunity	NN
cord-254492-42d77vxf	394	32	by	by	IN
cord-254492-42d77vxf	394	33	MDA5	mda5	JJ
cord-254492-42d77vxf	394	34	filaments	filament	NNS
cord-254492-42d77vxf	394	35	.	.	.
cord-254492-42d77vxf	395	1	Proc	proc	VB
cord-254492-42d77vxf	395	2	.	.	.
cord-254492-42d77vxf	396	1	Natl	Natl	NNP
cord-254492-42d77vxf	396	2	.	.	.
cord-254492-42d77vxf	397	1	Acad	Acad	NNP
cord-254492-42d77vxf	397	2	.	.	.
cord-254492-42d77vxf	398	1	Sci	Sci	NNP
cord-254492-42d77vxf	398	2	.	.	.
cord-254492-42d77vxf	399	1	USA	USA	NNP
cord-254492-42d77vxf	399	2	Structural	structural	JJ
cord-254492-42d77vxf	399	3	basis	basis	NN
cord-254492-42d77vxf	399	4	for	for	IN
cord-254492-42d77vxf	399	5	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	399	6	-	-	HYPH
cord-254492-42d77vxf	399	7	mediated	mediate	VBN
cord-254492-42d77vxf	399	8	antiviral	antiviral	JJ
cord-254492-42d77vxf	399	9	signal	signal	NN
cord-254492-42d77vxf	399	10	activation	activation	NN
cord-254492-42d77vxf	399	11	by	by	IN
cord-254492-42d77vxf	399	12	RIG-	RIG-	NNP
cord-254492-42d77vxf	400	1	I	-PRON-	PRP
cord-254492-42d77vxf	400	2	Species	species	NN
cord-254492-42d77vxf	400	3	-	-	HYPH
cord-254492-42d77vxf	400	4	specific	specific	JJ
cord-254492-42d77vxf	400	5	inhibition	inhibition	NN
cord-254492-42d77vxf	400	6	of	of	IN
cord-254492-42d77vxf	400	7	RIG	rig	NN
cord-254492-42d77vxf	400	8	-	-	:
cord-254492-42d77vxf	400	9	I	-PRON-	PRP
cord-254492-42d77vxf	400	10	ubiquitination	ubiquitination	RB
cord-254492-42d77vxf	400	11	and	and	CC
cord-254492-42d77vxf	400	12	IFN	IFN	NNP
cord-254492-42d77vxf	400	13	induction	induction	NN
cord-254492-42d77vxf	400	14	by	by	IN
cord-254492-42d77vxf	400	15	the	the	DT
cord-254492-42d77vxf	400	16	influenza	influenza	NN
cord-254492-42d77vxf	400	17	A	a	DT
cord-254492-42d77vxf	400	18	virus	virus	NN
cord-254492-42d77vxf	400	19	NS1	ns1	NN
cord-254492-42d77vxf	400	20	protein	protein	NN
cord-254492-42d77vxf	400	21	SENP2	senp2	RB
cord-254492-42d77vxf	400	22	negatively	negatively	RB
cord-254492-42d77vxf	400	23	regulates	regulate	VBZ
cord-254492-42d77vxf	400	24	cellular	cellular	JJ
cord-254492-42d77vxf	400	25	antiviral	antiviral	JJ
cord-254492-42d77vxf	400	26	response	response	NN
cord-254492-42d77vxf	400	27	by	by	IN
cord-254492-42d77vxf	400	28	deSUMOylating	deSUMOylating	NNP
cord-254492-42d77vxf	400	29	IRF3	IRF3	NNP
cord-254492-42d77vxf	400	30	and	and	CC
cord-254492-42d77vxf	400	31	conditioning	condition	VBG
cord-254492-42d77vxf	400	32	it	-PRON-	PRP
cord-254492-42d77vxf	400	33	for	for	IN
cord-254492-42d77vxf	401	1	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	401	2	and	and	CC
cord-254492-42d77vxf	401	3	degradation	degradation	NN
cord-254492-42d77vxf	401	4	NLRC5	nlrc5	NN
cord-254492-42d77vxf	401	5	interacts	interact	VBZ
cord-254492-42d77vxf	401	6	with	with	IN
cord-254492-42d77vxf	401	7	RIG	rig	NN
cord-254492-42d77vxf	401	8	-	-	:
cord-254492-42d77vxf	401	9	I	-PRON-	PRP
cord-254492-42d77vxf	401	10	to	to	TO
cord-254492-42d77vxf	401	11	induce	induce	VB
cord-254492-42d77vxf	401	12	a	a	DT
cord-254492-42d77vxf	401	13	robust	robust	JJ
cord-254492-42d77vxf	401	14	antiviral	antiviral	JJ
cord-254492-42d77vxf	401	15	response	response	NN
cord-254492-42d77vxf	401	16	against	against	IN
cord-254492-42d77vxf	401	17	influenza	influenza	NN
cord-254492-42d77vxf	401	18	virus	virus	NN
cord-254492-42d77vxf	401	19	infection	infection	NN
cord-254492-42d77vxf	401	20	Activation	activation	NN
cord-254492-42d77vxf	401	21	of	of	IN
cord-254492-42d77vxf	401	22	innate	innate	JJ
cord-254492-42d77vxf	401	23	immune	immune	JJ
cord-254492-42d77vxf	401	24	antiviral	antiviral	JJ
cord-254492-42d77vxf	401	25	responses	response	NNS
cord-254492-42d77vxf	401	26	by	by	IN
cord-254492-42d77vxf	401	27	Nod2	Nod2	NNP
cord-254492-42d77vxf	401	28	Regulation	Regulation	NNP
cord-254492-42d77vxf	401	29	of	of	IN
cord-254492-42d77vxf	401	30	innate	innate	JJ
cord-254492-42d77vxf	401	31	antiviral	antiviral	JJ
cord-254492-42d77vxf	401	32	defenses	defense	NNS
cord-254492-42d77vxf	401	33	through	through	IN
cord-254492-42d77vxf	401	34	a	a	DT
cord-254492-42d77vxf	401	35	shared	share	VBN
cord-254492-42d77vxf	401	36	repressor	repressor	NN
cord-254492-42d77vxf	401	37	domain	domain	NN
cord-254492-42d77vxf	401	38	in	in	IN
cord-254492-42d77vxf	401	39	RIG	rig	NN
cord-254492-42d77vxf	401	40	-	-	:
cord-254492-42d77vxf	401	41	I	I	NNP
cord-254492-42d77vxf	401	42	and	and	CC
cord-254492-42d77vxf	401	43	LGP2	LGP2	NNP
cord-254492-42d77vxf	401	44	Negative	negative	JJ
cord-254492-42d77vxf	401	45	regulation	regulation	NN
cord-254492-42d77vxf	401	46	of	of	IN
cord-254492-42d77vxf	401	47	interferon	interferon	NN
cord-254492-42d77vxf	401	48	-	-	HYPH
cord-254492-42d77vxf	401	49	regulatory	regulatory	JJ
cord-254492-42d77vxf	401	50	factor	factor	NN
cord-254492-42d77vxf	401	51	3-dependent	3-dependent	CD
cord-254492-42d77vxf	401	52	innate	innate	JJ
cord-254492-42d77vxf	401	53	antiviral	antiviral	JJ
cord-254492-42d77vxf	401	54	response	response	NN
cord-254492-42d77vxf	401	55	by	by	IN
cord-254492-42d77vxf	401	56	the	the	DT
cord-254492-42d77vxf	401	57	prolyl	prolyl	JJ
cord-254492-42d77vxf	401	58	isomerase	isomerase	NN
cord-254492-42d77vxf	401	59	Pin1	Pin1	NNP
cord-254492-42d77vxf	401	60	Master	Master	NNP
cord-254492-42d77vxf	401	61	sensors	sensor	NNS
cord-254492-42d77vxf	401	62	of	of	IN
cord-254492-42d77vxf	401	63	pathogenic	pathogenic	JJ
cord-254492-42d77vxf	401	64	RNA	RNA	NNP
cord-254492-42d77vxf	401	65	-RIG	-rig	ADD
cord-254492-42d77vxf	402	1	-I	-i	WDT
cord-254492-42d77vxf	402	2	like	like	IN
cord-254492-42d77vxf	402	3	receptors	receptor	NNS
cord-254492-42d77vxf	402	4	Recognition	recognition	NN
cord-254492-42d77vxf	402	5	of	of	IN
cord-254492-42d77vxf	402	6	5′	5′	CD
cord-254492-42d77vxf	402	7	triphosphate	triphosphate	NN
cord-254492-42d77vxf	402	8	by	by	IN
cord-254492-42d77vxf	402	9	RIG	rig	NN
cord-254492-42d77vxf	403	1	-I	-i	DT
cord-254492-42d77vxf	403	2	helicase	helicase	NNP
cord-254492-42d77vxf	403	3	requires	require	VBZ
cord-254492-42d77vxf	403	4	short	short	JJ
cord-254492-42d77vxf	403	5	blunt	blunt	JJ
cord-254492-42d77vxf	403	6	double	double	RB
cord-254492-42d77vxf	403	7	-	-	HYPH
cord-254492-42d77vxf	403	8	stranded	strand	VBN
cord-254492-42d77vxf	403	9	RNA	RNA	NNP
cord-254492-42d77vxf	403	10	as	as	IN
cord-254492-42d77vxf	403	11	contained	contain	VBN
cord-254492-42d77vxf	403	12	in	in	IN
cord-254492-42d77vxf	403	13	panhandle	panhandle	NN
cord-254492-42d77vxf	403	14	of	of	IN
cord-254492-42d77vxf	403	15	negative	negative	JJ
cord-254492-42d77vxf	403	16	-	-	HYPH
cord-254492-42d77vxf	403	17	strand	strand	NN
cord-254492-42d77vxf	403	18	virus	virus	NN
cord-254492-42d77vxf	403	19	SARS	SARS	NNP
cord-254492-42d77vxf	403	20	-	-	HYPH
cord-254492-42d77vxf	403	21	coronavirus	coronavirus	NN
cord-254492-42d77vxf	403	22	open	open	JJ
cord-254492-42d77vxf	403	23	reading	reading	NN
cord-254492-42d77vxf	404	1	frame-9b	frame-9b	NNP
cord-254492-42d77vxf	404	2	suppresses	suppress	VBZ
cord-254492-42d77vxf	404	3	innate	innate	JJ
cord-254492-42d77vxf	404	4	immunity	immunity	NN
cord-254492-42d77vxf	404	5	by	by	IN
cord-254492-42d77vxf	404	6	targeting	target	VBG
cord-254492-42d77vxf	404	7	mitochondria	mitochondrion	NNS
cord-254492-42d77vxf	404	8	and	and	CC
cord-254492-42d77vxf	404	9	the	the	DT
cord-254492-42d77vxf	404	10	MAVS/	MAVS/	NNP
cord-254492-42d77vxf	404	11	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	404	12	/	/	SYM
cord-254492-42d77vxf	404	13	TRAF6	TRAF6	NNP
cord-254492-42d77vxf	404	14	signalosome	signalosome	NNP
cord-254492-42d77vxf	405	1	Positive	positive	JJ
cord-254492-42d77vxf	405	2	regulation	regulation	NN
cord-254492-42d77vxf	405	3	of	of	IN
cord-254492-42d77vxf	405	4	interferon	interferon	NN
cord-254492-42d77vxf	405	5	regulatory	regulatory	JJ
cord-254492-42d77vxf	405	6	factor	factor	NN
cord-254492-42d77vxf	405	7	3	3	CD
cord-254492-42d77vxf	405	8	activation	activation	NN
cord-254492-42d77vxf	405	9	by	by	IN
cord-254492-42d77vxf	405	10	Herc5	Herc5	NNP
cord-254492-42d77vxf	406	1	via	via	IN
cord-254492-42d77vxf	406	2	ISG15	ISG15	NNP
cord-254492-42d77vxf	406	3	modification	modification	NN
cord-254492-42d77vxf	407	1	NLRX1	NLRX1	NNP
cord-254492-42d77vxf	407	2	does	do	VBZ
cord-254492-42d77vxf	407	3	not	not	RB
cord-254492-42d77vxf	407	4	inhibit	inhibit	VB
cord-254492-42d77vxf	407	5	MAVS	MAVS	NNP
cord-254492-42d77vxf	407	6	-	-	HYPH
cord-254492-42d77vxf	407	7	dependent	dependent	JJ
cord-254492-42d77vxf	407	8	antiviral	antiviral	JJ
cord-254492-42d77vxf	407	9	signalling	signalling	NN
cord-254492-42d77vxf	407	10	ITCH	itch	NN
cord-254492-42d77vxf	408	1	K63-ubiquitinates	K63-ubiquitinates	NNP
cord-254492-42d77vxf	408	2	the	the	DT
cord-254492-42d77vxf	408	3	NOD2	NOD2	NNPS
cord-254492-42d77vxf	408	4	binding	bind	VBG
cord-254492-42d77vxf	408	5	protein	protein	NN
cord-254492-42d77vxf	408	6	,	,	,
cord-254492-42d77vxf	408	7	RIP2	RIP2	NNP
cord-254492-42d77vxf	408	8	,	,	,
cord-254492-42d77vxf	408	9	to	to	TO
cord-254492-42d77vxf	408	10	influence	influence	VB
cord-254492-42d77vxf	408	11	inflammatory	inflammatory	JJ
cord-254492-42d77vxf	408	12	signaling	signal	VBG
cord-254492-42d77vxf	408	13	pathways	pathway	NNS
cord-254492-42d77vxf	409	1	NLRX1	NLRX1	NNP
cord-254492-42d77vxf	409	2	is	be	VBZ
cord-254492-42d77vxf	409	3	a	a	DT
cord-254492-42d77vxf	409	4	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	409	5	NOD	nod	NN
cord-254492-42d77vxf	409	6	-	-	HYPH
cord-254492-42d77vxf	409	7	like	like	JJ
cord-254492-42d77vxf	409	8	receptor	receptor	NN
cord-254492-42d77vxf	409	9	that	that	WDT
cord-254492-42d77vxf	409	10	amplifies	amplify	VBZ
cord-254492-42d77vxf	409	11	NF	nf	NN
cord-254492-42d77vxf	409	12	-	-	HYPH
cord-254492-42d77vxf	409	13	κB	κB	NNP
cord-254492-42d77vxf	409	14	and	and	CC
cord-254492-42d77vxf	409	15	JNK	JNK	NNP
cord-254492-42d77vxf	409	16	pathways	pathway	NNS
cord-254492-42d77vxf	409	17	by	by	IN
cord-254492-42d77vxf	409	18	inducing	induce	VBG
cord-254492-42d77vxf	409	19	reactive	reactive	JJ
cord-254492-42d77vxf	409	20	oxygen	oxygen	NN
cord-254492-42d77vxf	409	21	species	specie	NNS
cord-254492-42d77vxf	409	22	production	production	NN
cord-254492-42d77vxf	409	23	Activation	activation	NN
cord-254492-42d77vxf	409	24	of	of	IN
cord-254492-42d77vxf	409	25	TBK1	TBK1	NNP
cord-254492-42d77vxf	409	26	and	and	CC
cord-254492-42d77vxf	409	27	IKKε	IKKε	NNS
cord-254492-42d77vxf	409	28	kinases	kinase	NNS
cord-254492-42d77vxf	409	29	by	by	IN
cord-254492-42d77vxf	409	30	vesicular	vesicular	JJ
cord-254492-42d77vxf	409	31	stomatitis	stomatitis	NN
cord-254492-42d77vxf	409	32	virus	virus	NN
cord-254492-42d77vxf	409	33	infection	infection	NN
cord-254492-42d77vxf	409	34	and	and	CC
cord-254492-42d77vxf	409	35	the	the	DT
cord-254492-42d77vxf	409	36	role	role	NN
cord-254492-42d77vxf	409	37	of	of	IN
cord-254492-42d77vxf	409	38	viral	viral	JJ
cord-254492-42d77vxf	409	39	ribonucleoprotein	ribonucleoprotein	NN
cord-254492-42d77vxf	409	40	in	in	IN
cord-254492-42d77vxf	409	41	the	the	DT
cord-254492-42d77vxf	409	42	development	development	NN
cord-254492-42d77vxf	409	43	of	of	IN
cord-254492-42d77vxf	409	44	interferon	interferon	NN
cord-254492-42d77vxf	409	45	antiviral	antiviral	JJ
cord-254492-42d77vxf	409	46	immunity	immunity	NN
cord-254492-42d77vxf	410	1	A	a	DT
cord-254492-42d77vxf	410	2	discrete	discrete	JJ
cord-254492-42d77vxf	410	3	ubiquitinmediated	ubiquitinmediated	JJ
cord-254492-42d77vxf	410	4	network	network	NN
cord-254492-42d77vxf	410	5	regulates	regulate	VBZ
cord-254492-42d77vxf	410	6	the	the	DT
cord-254492-42d77vxf	410	7	strength	strength	NN
cord-254492-42d77vxf	410	8	of	of	IN
cord-254492-42d77vxf	410	9	NOD2	NOD2	NNPS
cord-254492-42d77vxf	410	10	signaling	signal	VBG
cord-254492-42d77vxf	410	11	Different	different	JJ
cord-254492-42d77vxf	410	12	modes	mode	NNS
cord-254492-42d77vxf	410	13	of	of	IN
cord-254492-42d77vxf	410	14	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	410	15	of	of	IN
cord-254492-42d77vxf	410	16	the	the	DT
cord-254492-42d77vxf	410	17	adaptor	adaptor	NN
cord-254492-42d77vxf	410	18	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	410	19	selectively	selectively	RB
cord-254492-42d77vxf	410	20	activate	activate	VBP
cord-254492-42d77vxf	410	21	the	the	DT
cord-254492-42d77vxf	410	22	expression	expression	NN
cord-254492-42d77vxf	410	23	of	of	IN
cord-254492-42d77vxf	410	24	type	type	NN
cord-254492-42d77vxf	410	25	I	-PRON-	PRP
cord-254492-42d77vxf	410	26	interferons	interferon	NNS
cord-254492-42d77vxf	410	27	and	and	CC
cord-254492-42d77vxf	410	28	proinflammatory	proinflammatory	JJ
cord-254492-42d77vxf	410	29	cytokines	cytokine	NNS
cord-254492-42d77vxf	411	1	Homeostatic	Homeostatic	NNP
cord-254492-42d77vxf	411	2	MyD88-dependent	MyD88-dependent	NNP
cord-254492-42d77vxf	412	1	signals	signal	NNS
cord-254492-42d77vxf	412	2	cause	cause	VBP
cord-254492-42d77vxf	412	3	lethal	lethal	JJ
cord-254492-42d77vxf	412	4	inflammation	inflammation	NN
cord-254492-42d77vxf	412	5	in	in	IN
cord-254492-42d77vxf	412	6	the	the	DT
cord-254492-42d77vxf	412	7	absence	absence	NN
cord-254492-42d77vxf	412	8	of	of	IN
cord-254492-42d77vxf	412	9	A20	A20	NNP
cord-254492-42d77vxf	412	10	Herpes	Herpes	NNP
cord-254492-42d77vxf	412	11	simplex	simplex	NN
cord-254492-42d77vxf	412	12	virus	virus	NN
cord-254492-42d77vxf	412	13	immediate	immediate	JJ
cord-254492-42d77vxf	412	14	-	-	HYPH
cord-254492-42d77vxf	412	15	early	early	JJ
cord-254492-42d77vxf	412	16	ICP0	ICP0	NNP
cord-254492-42d77vxf	412	17	protein	protein	NN
cord-254492-42d77vxf	412	18	inhibits	inhibit	VBZ
cord-254492-42d77vxf	412	19	Toll	toll	NN
cord-254492-42d77vxf	412	20	-	-	HYPH
cord-254492-42d77vxf	412	21	like	like	JJ
cord-254492-42d77vxf	412	22	receptor	receptor	NN
cord-254492-42d77vxf	412	23	2-dependent	2-dependent	CD
cord-254492-42d77vxf	412	24	inflammatory	inflammatory	JJ
cord-254492-42d77vxf	412	25	responses	response	NNS
cord-254492-42d77vxf	412	26	and	and	CC
cord-254492-42d77vxf	413	1	NF	NF	NNP
cord-254492-42d77vxf	413	2	-	-	HYPH
cord-254492-42d77vxf	413	3	κB	κB	NNP
cord-254492-42d77vxf	413	4	signaling	signal	VBG
cord-254492-42d77vxf	413	5	Proteomic	Proteomic	NNP
cord-254492-42d77vxf	413	6	profiling	profiling	NN
cord-254492-42d77vxf	413	7	of	of	IN
cord-254492-42d77vxf	413	8	the	the	DT
cord-254492-42d77vxf	413	9	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	413	10	interactome	interactome	NNP
cord-254492-42d77vxf	413	11	network	network	NN
cord-254492-42d77vxf	413	12	reveals	reveal	VBZ
cord-254492-42d77vxf	413	13	a	a	DT
cord-254492-42d77vxf	413	14	new	new	JJ
cord-254492-42d77vxf	413	15	role	role	NN
cord-254492-42d77vxf	413	16	for	for	IN
cord-254492-42d77vxf	413	17	the	the	DT
cord-254492-42d77vxf	413	18	ER	ER	NNP
cord-254492-42d77vxf	413	19	-	-	HYPH
cord-254492-42d77vxf	413	20	to	to	IN
cord-254492-42d77vxf	413	21	-	-	HYPH
cord-254492-42d77vxf	413	22	Golgi	golgi	NN
cord-254492-42d77vxf	413	23	transport	transport	NN
cord-254492-42d77vxf	413	24	compartments	compartment	NNS
cord-254492-42d77vxf	413	25	in	in	IN
cord-254492-42d77vxf	413	26	innate	innate	JJ
cord-254492-42d77vxf	413	27	immunity	immunity	NN
cord-254492-42d77vxf	414	1	The	the	DT
cord-254492-42d77vxf	414	2	E3	e3	NN
cord-254492-42d77vxf	414	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	414	4	ligase	ligase	NN
cord-254492-42d77vxf	414	5	Nrdp1	Nrdp1	NNP
cord-254492-42d77vxf	414	6	'	'	POS
cord-254492-42d77vxf	414	7	preferentially	preferentially	RB
cord-254492-42d77vxf	414	8	'	'	POS
cord-254492-42d77vxf	414	9	promotes	promote	VBZ
cord-254492-42d77vxf	414	10	TLR	tlr	NN
cord-254492-42d77vxf	414	11	-	-	HYPH
cord-254492-42d77vxf	414	12	mediated	mediate	VBN
cord-254492-42d77vxf	414	13	production	production	NN
cord-254492-42d77vxf	414	14	of	of	IN
cord-254492-42d77vxf	414	15	type	type	NN
cord-254492-42d77vxf	415	1	I	-PRON-	PRP
cord-254492-42d77vxf	415	2	interferon	interferon	VBD
cord-254492-42d77vxf	415	3	NEMO	NEMO	NNP
cord-254492-42d77vxf	415	4	binds	bind	VBZ
cord-254492-42d77vxf	415	5	ubiquitinated	ubiquitinated	JJ
cord-254492-42d77vxf	415	6	TANKbinding	tankbinding	NN
cord-254492-42d77vxf	415	7	kinase	kinase	NN
cord-254492-42d77vxf	415	8	1	1	CD
cord-254492-42d77vxf	415	9	(	(	-LRB-
cord-254492-42d77vxf	415	10	TBK1	TBK1	NNP
cord-254492-42d77vxf	415	11	)	)	-RRB-
cord-254492-42d77vxf	415	12	to	to	TO
cord-254492-42d77vxf	415	13	regulate	regulate	VB
cord-254492-42d77vxf	415	14	innate	innate	JJ
cord-254492-42d77vxf	415	15	immune	immune	JJ
cord-254492-42d77vxf	415	16	responses	response	NNS
cord-254492-42d77vxf	415	17	to	to	IN
cord-254492-42d77vxf	415	18	RNA	RNA	NNP
cord-254492-42d77vxf	415	19	viruses	virus	NNS
cord-254492-42d77vxf	415	20	USP4	USP4	NNP
cord-254492-42d77vxf	416	1	positively	positively	RB
cord-254492-42d77vxf	416	2	regulates	regulate	VBZ
cord-254492-42d77vxf	416	3	RIG	rig	NN
cord-254492-42d77vxf	416	4	-	-	HYPH
cord-254492-42d77vxf	416	5	I	i	NN
cord-254492-42d77vxf	416	6	-	-	HYPH
cord-254492-42d77vxf	416	7	mediated	mediate	VBN
cord-254492-42d77vxf	416	8	antiviral	antiviral	JJ
cord-254492-42d77vxf	416	9	response	response	NN
cord-254492-42d77vxf	416	10	through	through	IN
cord-254492-42d77vxf	416	11	deubiquitination	deubiquitination	NN
cord-254492-42d77vxf	416	12	and	and	CC
cord-254492-42d77vxf	416	13	stabilization	stabilization	NN
cord-254492-42d77vxf	416	14	of	of	IN
cord-254492-42d77vxf	416	15	RIG	rig	NN
cord-254492-42d77vxf	417	1	-I	-I	NFP
cord-254492-42d77vxf	417	2	TRIM26	TRIM26	NNP
cord-254492-42d77vxf	417	3	negatively	negatively	RB
cord-254492-42d77vxf	417	4	regulates	regulate	VBZ
cord-254492-42d77vxf	417	5	interferon	interferon	NN
cord-254492-42d77vxf	417	6	-	-	HYPH
cord-254492-42d77vxf	417	7	β	β	NN
cord-254492-42d77vxf	417	8	production	production	NN
cord-254492-42d77vxf	417	9	and	and	CC
cord-254492-42d77vxf	417	10	antiviral	antiviral	JJ
cord-254492-42d77vxf	417	11	response	response	NN
cord-254492-42d77vxf	417	12	through	through	IN
cord-254492-42d77vxf	417	13	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	417	14	and	and	CC
cord-254492-42d77vxf	417	15	degradation	degradation	NN
cord-254492-42d77vxf	417	16	of	of	IN
cord-254492-42d77vxf	417	17	nuclear	nuclear	JJ
cord-254492-42d77vxf	417	18	IRF3	IRF3	NNP
cord-254492-42d77vxf	417	19	Herpes	Herpes	NNP
cord-254492-42d77vxf	417	20	simplex	simplex	NN
cord-254492-42d77vxf	417	21	virus	virus	NN
cord-254492-42d77vxf	417	22	1	1	CD
cord-254492-42d77vxf	417	23	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	417	24	-	-	HYPH
cord-254492-42d77vxf	417	25	specific	specific	JJ
cord-254492-42d77vxf	417	26	protease	protease	NN
cord-254492-42d77vxf	418	1	UL36	UL36	NNP
cord-254492-42d77vxf	418	2	inhibits	inhibit	VBZ
cord-254492-42d77vxf	418	3	beta	beta	NN
cord-254492-42d77vxf	418	4	interferon	interferon	NN
cord-254492-42d77vxf	418	5	production	production	NN
cord-254492-42d77vxf	418	6	by	by	IN
cord-254492-42d77vxf	418	7	deubiquitinating	deubiquitinate	VBG
cord-254492-42d77vxf	418	8	TRAF3	traf3	XX
cord-254492-42d77vxf	419	1	Tetraspanin	Tetraspanin	NNP
cord-254492-42d77vxf	419	2	6	6	CD
cord-254492-42d77vxf	419	3	(	(	-LRB-
cord-254492-42d77vxf	419	4	TSP	TSP	NNP
cord-254492-42d77vxf	419	5	AN6	AN6	NNP
cord-254492-42d77vxf	419	6	)	)	-RRB-
cord-254492-42d77vxf	419	7	negatively	negatively	RB
cord-254492-42d77vxf	419	8	regulates	regulate	VBZ
cord-254492-42d77vxf	419	9	retinoic	retinoic	JJ
cord-254492-42d77vxf	419	10	acid	acid	NN
cord-254492-42d77vxf	419	11	-	-	HYPH
cord-254492-42d77vxf	419	12	inducible	inducible	JJ
cord-254492-42d77vxf	419	13	gene	gene	NN
cord-254492-42d77vxf	420	1	I	-PRON-	PRP
cord-254492-42d77vxf	420	2	-	-	HYPH
cord-254492-42d77vxf	420	3	like	like	JJ
cord-254492-42d77vxf	420	4	receptor	receptor	NN
cord-254492-42d77vxf	420	5	-	-	HYPH
cord-254492-42d77vxf	420	6	mediated	mediate	VBN
cord-254492-42d77vxf	420	7	immune	immune	NN
cord-254492-42d77vxf	420	8	signaling	signaling	NN
cord-254492-42d77vxf	420	9	in	in	IN
cord-254492-42d77vxf	420	10	a	a	DT
cord-254492-42d77vxf	420	11	ubiquitinationdependent	ubiquitinationdependent	NN
cord-254492-42d77vxf	420	12	manner	manner	NN
cord-254492-42d77vxf	421	1	Ndfip1	Ndfip1	NNP
cord-254492-42d77vxf	421	2	negatively	negatively	RB
cord-254492-42d77vxf	421	3	regulates	regulate	VBZ
cord-254492-42d77vxf	421	4	RIG	rig	NN
cord-254492-42d77vxf	421	5	-	-	:
cord-254492-42d77vxf	421	6	Idependent	Idependent	NNP
cord-254492-42d77vxf	421	7	immune	immune	NN
cord-254492-42d77vxf	421	8	signaling	signal	VBG
cord-254492-42d77vxf	421	9	by	by	IN
cord-254492-42d77vxf	421	10	enhancing	enhance	VBG
cord-254492-42d77vxf	421	11	E3	E3	NNP
cord-254492-42d77vxf	421	12	ligase	ligase	NN
cord-254492-42d77vxf	421	13	Smurf1-mediated	Smurf1-mediated	NNP
cord-254492-42d77vxf	421	14	MAVS	MAVS	NNP
cord-254492-42d77vxf	421	15	degradation	degradation	NN
cord-254492-42d77vxf	422	1	The	the	DT
cord-254492-42d77vxf	422	2	hepatitis	hepatitis	NN
cord-254492-42d77vxf	422	3	B	B	NNP
cord-254492-42d77vxf	422	4	virus	virus	NN
cord-254492-42d77vxf	422	5	X	x	NN
cord-254492-42d77vxf	422	6	protein	protein	NN
cord-254492-42d77vxf	422	7	disrupts	disrupt	VBZ
cord-254492-42d77vxf	422	8	innate	innate	JJ
cord-254492-42d77vxf	422	9	immunity	immunity	NN
cord-254492-42d77vxf	422	10	by	by	IN
cord-254492-42d77vxf	422	11	downregulating	downregulate	VBG
cord-254492-42d77vxf	422	12	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	422	13	antiviral	antiviral	JJ
cord-254492-42d77vxf	422	14	signaling	signal	VBG
cord-254492-42d77vxf	422	15	protein	protein	NN
cord-254492-42d77vxf	423	1	TRIM4	TRIM4	NNP
cord-254492-42d77vxf	423	2	modulates	modulate	VBZ
cord-254492-42d77vxf	423	3	type	type	NN
cord-254492-42d77vxf	424	1	I	-PRON-	PRP
cord-254492-42d77vxf	424	2	interferon	interferon	VBD
cord-254492-42d77vxf	424	3	induction	induction	NN
cord-254492-42d77vxf	424	4	and	and	CC
cord-254492-42d77vxf	424	5	cellular	cellular	JJ
cord-254492-42d77vxf	424	6	antiviral	antiviral	JJ
cord-254492-42d77vxf	424	7	response	response	NN
cord-254492-42d77vxf	424	8	by	by	IN
cord-254492-42d77vxf	424	9	targeting	target	VBG
cord-254492-42d77vxf	424	10	RIG	rig	NN
cord-254492-42d77vxf	424	11	-	-	:
cord-254492-42d77vxf	424	12	I	-PRON-	PRP
cord-254492-42d77vxf	424	13	for	for	IN
cord-254492-42d77vxf	424	14	K63-linked	K63-linked	NNP
cord-254492-42d77vxf	424	15	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	425	1	TRIM21	TRIM21	NNP
cord-254492-42d77vxf	425	2	is	be	VBZ
cord-254492-42d77vxf	425	3	essential	essential	JJ
cord-254492-42d77vxf	425	4	to	to	TO
cord-254492-42d77vxf	425	5	sustain	sustain	VB
cord-254492-42d77vxf	425	6	IFN	IFN	NNP
cord-254492-42d77vxf	425	7	regulatory	regulatory	JJ
cord-254492-42d77vxf	425	8	factor	factor	NN
cord-254492-42d77vxf	425	9	3	3	CD
cord-254492-42d77vxf	425	10	activation	activation	NN
cord-254492-42d77vxf	425	11	during	during	IN
cord-254492-42d77vxf	425	12	antiviral	antiviral	JJ
cord-254492-42d77vxf	425	13	response	response	NN
cord-254492-42d77vxf	426	1	The	the	DT
cord-254492-42d77vxf	426	2	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	426	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	426	4	ligase	ligase	NN
cord-254492-42d77vxf	426	5	MAR	MAR	NNP
cord-254492-42d77vxf	426	6	CH5	CH5	NNP
cord-254492-42d77vxf	426	7	resolves	resolve	VBZ
cord-254492-42d77vxf	426	8	MAVS	MAVS	NNP
cord-254492-42d77vxf	426	9	aggregates	aggregate	NNS
cord-254492-42d77vxf	426	10	during	during	IN
cord-254492-42d77vxf	426	11	antiviral	antiviral	JJ
cord-254492-42d77vxf	426	12	signalling	signal	VBG
cord-254492-42d77vxf	426	13	TRAF6	traf6	NN
cord-254492-42d77vxf	426	14	and	and	CC
cord-254492-42d77vxf	426	15	MEKK1	mekk1	NN
cord-254492-42d77vxf	426	16	play	play	VB
cord-254492-42d77vxf	426	17	a	a	DT
cord-254492-42d77vxf	426	18	pivotal	pivotal	JJ
cord-254492-42d77vxf	426	19	role	role	NN
cord-254492-42d77vxf	426	20	in	in	IN
cord-254492-42d77vxf	426	21	the	the	DT
cord-254492-42d77vxf	426	22	RIG	rig	NN
cord-254492-42d77vxf	426	23	-	-	HYPH
cord-254492-42d77vxf	426	24	I	i	NN
cord-254492-42d77vxf	426	25	-	-	HYPH
cord-254492-42d77vxf	426	26	like	like	JJ
cord-254492-42d77vxf	426	27	helicase	helicase	NN
cord-254492-42d77vxf	426	28	antiviral	antiviral	JJ
cord-254492-42d77vxf	426	29	pathway	pathway	NN
cord-254492-42d77vxf	426	30	PCBP2	PCBP2	NNP
cord-254492-42d77vxf	427	1	mediates	mediate	VBZ
cord-254492-42d77vxf	427	2	degradation	degradation	NN
cord-254492-42d77vxf	427	3	of	of	IN
cord-254492-42d77vxf	427	4	the	the	DT
cord-254492-42d77vxf	427	5	adaptor	adaptor	NN
cord-254492-42d77vxf	427	6	MAVS	MAVS	NNPS
cord-254492-42d77vxf	427	7	via	via	IN
cord-254492-42d77vxf	427	8	the	the	DT
cord-254492-42d77vxf	427	9	HECT	HECT	NNP
cord-254492-42d77vxf	427	10	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	427	11	ligase	ligase	NN
cord-254492-42d77vxf	428	1	AIP4	AIP4	NNP
cord-254492-42d77vxf	429	1	The	the	DT
cord-254492-42d77vxf	429	2	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	429	3	E3	e3	NN
cord-254492-42d77vxf	429	4	ligase	ligase	NN
cord-254492-42d77vxf	429	5	RAUL	RAUL	NNP
cord-254492-42d77vxf	429	6	negatively	negatively	RB
cord-254492-42d77vxf	429	7	regulates	regulate	VBZ
cord-254492-42d77vxf	429	8	type	type	NN
cord-254492-42d77vxf	429	9	I	-PRON-	PRP
cord-254492-42d77vxf	429	10	interferon	interferon	VBD
cord-254492-42d77vxf	429	11	through	through	IN
cord-254492-42d77vxf	429	12	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	429	13	of	of	IN
cord-254492-42d77vxf	429	14	the	the	DT
cord-254492-42d77vxf	429	15	transcription	transcription	NN
cord-254492-42d77vxf	429	16	factors	factor	NNS
cord-254492-42d77vxf	429	17	IRF7	IRF7	NNP
cord-254492-42d77vxf	429	18	and	and	CC
cord-254492-42d77vxf	429	19	IRF3	IRF3	NNP
cord-254492-42d77vxf	430	1	The	the	DT
cord-254492-42d77vxf	430	2	KSHV	KSHV	NNP
cord-254492-42d77vxf	430	3	immediate	immediate	JJ
cord-254492-42d77vxf	430	4	-	-	HYPH
cord-254492-42d77vxf	430	5	early	early	JJ
cord-254492-42d77vxf	430	6	transcription	transcription	NN
cord-254492-42d77vxf	430	7	factor	factor	NN
cord-254492-42d77vxf	430	8	RTA	RTA	NNP
cord-254492-42d77vxf	430	9	encodes	encode	VBZ
cord-254492-42d77vxf	430	10	ubiquitin	ubiquitin	JJ
cord-254492-42d77vxf	430	11	E3	e3	NN
cord-254492-42d77vxf	430	12	ligase	ligase	NN
cord-254492-42d77vxf	430	13	activity	activity	NN
cord-254492-42d77vxf	430	14	that	that	WDT
cord-254492-42d77vxf	430	15	targets	target	VBZ
cord-254492-42d77vxf	430	16	IRF7	IRF7	NNP
cord-254492-42d77vxf	430	17	for	for	IN
cord-254492-42d77vxf	430	18	proteosome	proteosome	NN
cord-254492-42d77vxf	430	19	-	-	HYPH
cord-254492-42d77vxf	430	20	mediated	mediate	VBN
cord-254492-42d77vxf	430	21	degradation	degradation	NN
cord-254492-42d77vxf	430	22	Control	control	NN
cord-254492-42d77vxf	430	23	of	of	IN
cord-254492-42d77vxf	430	24	canonical	canonical	JJ
cord-254492-42d77vxf	430	25	NF	nf	NN
cord-254492-42d77vxf	430	26	-	-	HYPH
cord-254492-42d77vxf	430	27	κB	κb	CD
cord-254492-42d77vxf	430	28	activation	activation	NN
cord-254492-42d77vxf	430	29	through	through	IN
cord-254492-42d77vxf	430	30	the	the	DT
cord-254492-42d77vxf	430	31	NIK	NIK	NNP
cord-254492-42d77vxf	430	32	-	-	HYPH
cord-254492-42d77vxf	430	33	IKK	IKK	NNP
cord-254492-42d77vxf	430	34	complex	complex	JJ
cord-254492-42d77vxf	430	35	pathway	pathway	NN
cord-254492-42d77vxf	430	36	Key	key	JJ
cord-254492-42d77vxf	430	37	role	role	NN
cord-254492-42d77vxf	430	38	of	of	IN
cord-254492-42d77vxf	430	39	Ubc5	Ubc5	NNP
cord-254492-42d77vxf	430	40	and	and	CC
cord-254492-42d77vxf	430	41	lysine-63	lysine-63	NNP
cord-254492-42d77vxf	430	42	polyubiquitination	polyubiquitination	NN
cord-254492-42d77vxf	430	43	in	in	IN
cord-254492-42d77vxf	430	44	viral	viral	JJ
cord-254492-42d77vxf	430	45	activation	activation	NN
cord-254492-42d77vxf	430	46	of	of	IN
cord-254492-42d77vxf	430	47	IRF3	IRF3	NNP
cord-254492-42d77vxf	430	48	An	an	DT
cord-254492-42d77vxf	430	49	unexpected	unexpected	JJ
cord-254492-42d77vxf	430	50	twist	twist	NN
cord-254492-42d77vxf	430	51	to	to	IN
cord-254492-42d77vxf	430	52	the	the	DT
cord-254492-42d77vxf	430	53	activation	activation	NN
cord-254492-42d77vxf	430	54	of	of	IN
cord-254492-42d77vxf	430	55	IKKβ	IKKβ	NNS
cord-254492-42d77vxf	430	56	:	:	:
cord-254492-42d77vxf	431	1	TAK1	TAK1	NNP
cord-254492-42d77vxf	431	2	primes	prime	NNS
cord-254492-42d77vxf	431	3	IKKβ	IKKβ	NNS
cord-254492-42d77vxf	431	4	for	for	IN
cord-254492-42d77vxf	431	5	activation	activation	NN
cord-254492-42d77vxf	431	6	by	by	IN
cord-254492-42d77vxf	431	7	autophosphorylation	autophosphorylation	NN
cord-254492-42d77vxf	431	8	Negative	negative	JJ
cord-254492-42d77vxf	431	9	feedback	feedback	NN
cord-254492-42d77vxf	431	10	regulation	regulation	NN
cord-254492-42d77vxf	431	11	of	of	IN
cord-254492-42d77vxf	431	12	cellular	cellular	JJ
cord-254492-42d77vxf	431	13	antiviral	antiviral	JJ
cord-254492-42d77vxf	431	14	signaling	signaling	NN
cord-254492-42d77vxf	431	15	by	by	IN
cord-254492-42d77vxf	431	16	RBCK1-mediated	rbck1-mediate	VBN
cord-254492-42d77vxf	431	17	degradation	degradation	NN
cord-254492-42d77vxf	431	18	of	of	IN
cord-254492-42d77vxf	432	1	IRF3	IRF3	NNP
cord-254492-42d77vxf	432	2	Kaposi	Kaposi	NNP
cord-254492-42d77vxf	432	3	's	's	POS
cord-254492-42d77vxf	432	4	sarcoma	sarcoma	NN
cord-254492-42d77vxf	432	5	-	-	HYPH
cord-254492-42d77vxf	432	6	associated	associate	VBN
cord-254492-42d77vxf	432	7	herpesvirus	herpesvirus	NN
cord-254492-42d77vxf	432	8	-	-	HYPH
cord-254492-42d77vxf	432	9	encoded	encode	VBN
cord-254492-42d77vxf	432	10	replication	replication	NN
cord-254492-42d77vxf	432	11	and	and	CC
cord-254492-42d77vxf	432	12	transcription	transcription	NN
cord-254492-42d77vxf	432	13	activator	activator	NN
cord-254492-42d77vxf	432	14	impairs	impair	VBZ
cord-254492-42d77vxf	432	15	innate	innate	JJ
cord-254492-42d77vxf	432	16	immunity	immunity	NN
cord-254492-42d77vxf	432	17	via	via	IN
cord-254492-42d77vxf	432	18	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	432	19	-	-	HYPH
cord-254492-42d77vxf	432	20	mediated	mediate	VBN
cord-254492-42d77vxf	432	21	degradation	degradation	NN
cord-254492-42d77vxf	432	22	of	of	IN
cord-254492-42d77vxf	432	23	myeloid	myeloid	JJ
cord-254492-42d77vxf	432	24	differentiation	differentiation	NN
cord-254492-42d77vxf	432	25	factor	factor	NN
cord-254492-42d77vxf	432	26	88	88	CD
cord-254492-42d77vxf	433	1	The	the	DT
cord-254492-42d77vxf	433	2	NEMO	NEMO	NNP
cord-254492-42d77vxf	433	3	adaptor	adaptor	NN
cord-254492-42d77vxf	433	4	bridges	bridge	NNS
cord-254492-42d77vxf	433	5	the	the	DT
cord-254492-42d77vxf	433	6	nuclear	nuclear	JJ
cord-254492-42d77vxf	433	7	factor-	factor-	XX
cord-254492-42d77vxf	434	1	κB	κB	NNP
cord-254492-42d77vxf	434	2	and	and	CC
cord-254492-42d77vxf	434	3	interferon	interferon	NN
cord-254492-42d77vxf	434	4	regulatory	regulatory	JJ
cord-254492-42d77vxf	434	5	factor	factor	NN
cord-254492-42d77vxf	434	6	signaling	signal	VBG
cord-254492-42d77vxf	434	7	pathways	pathway	NNS
cord-254492-42d77vxf	435	1	The	the	DT
cord-254492-42d77vxf	435	2	E3	e3	NN
cord-254492-42d77vxf	435	3	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	435	4	ligase	ligase	NN
cord-254492-42d77vxf	435	5	RNF5	RNF5	NNP
cord-254492-42d77vxf	435	6	targets	target	NNS
cord-254492-42d77vxf	435	7	virus	virus	NN
cord-254492-42d77vxf	435	8	-	-	HYPH
cord-254492-42d77vxf	435	9	induced	induce	VBN
cord-254492-42d77vxf	435	10	signaling	signal	VBG
cord-254492-42d77vxf	435	11	adaptor	adaptor	NN
cord-254492-42d77vxf	435	12	for	for	IN
cord-254492-42d77vxf	435	13	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	435	14	and	and	CC
cord-254492-42d77vxf	435	15	degradation	degradation	NN
cord-254492-42d77vxf	435	16	Negative	negative	JJ
cord-254492-42d77vxf	435	17	regulation	regulation	NN
cord-254492-42d77vxf	435	18	of	of	IN
cord-254492-42d77vxf	435	19	IL-17-mediated	il-17-mediated	JJ
cord-254492-42d77vxf	435	20	signaling	signaling	NN
cord-254492-42d77vxf	435	21	and	and	CC
cord-254492-42d77vxf	435	22	inflammation	inflammation	NN
cord-254492-42d77vxf	435	23	by	by	IN
cord-254492-42d77vxf	435	24	the	the	DT
cord-254492-42d77vxf	435	25	ubiquitin	ubiquitin	NN
cord-254492-42d77vxf	435	26	-	-	HYPH
cord-254492-42d77vxf	435	27	specific	specific	JJ
cord-254492-42d77vxf	435	28	protease	protease	NN
cord-254492-42d77vxf	435	29	USP25	USP25	NNP
cord-254492-42d77vxf	435	30	Ubiquitin	Ubiquitin	NNP
cord-254492-42d77vxf	435	31	-	-	HYPH
cord-254492-42d77vxf	435	32	specific	specific	JJ
cord-254492-42d77vxf	435	33	protease	protease	NN
cord-254492-42d77vxf	435	34	25	25	CD
cord-254492-42d77vxf	435	35	regulates	regulate	VBZ
cord-254492-42d77vxf	435	36	TLR4-dependent	tlr4-dependent	NN
cord-254492-42d77vxf	435	37	innate	innate	JJ
cord-254492-42d77vxf	435	38	immune	immune	JJ
cord-254492-42d77vxf	435	39	responses	response	NNS
cord-254492-42d77vxf	435	40	through	through	IN
cord-254492-42d77vxf	435	41	deubiquitination	deubiquitination	NN
cord-254492-42d77vxf	435	42	of	of	IN
cord-254492-42d77vxf	435	43	the	the	DT
cord-254492-42d77vxf	435	44	adaptor	adaptor	NN
cord-254492-42d77vxf	435	45	protein	protein	NN
cord-254492-42d77vxf	435	46	TRAF3	TRAF3	NNP
cord-254492-42d77vxf	435	47	Poly(C)-binding	poly(c)-binde	VBG
cord-254492-42d77vxf	435	48	protein	protein	NN
cord-254492-42d77vxf	435	49	1	1	CD
cord-254492-42d77vxf	435	50	(	(	-LRB-
cord-254492-42d77vxf	435	51	PCBP1	PCBP1	NNS
cord-254492-42d77vxf	435	52	)	)	-RRB-
cord-254492-42d77vxf	436	1	mediates	mediate	VBZ
cord-254492-42d77vxf	436	2	housekeeping	housekeeping	NN
cord-254492-42d77vxf	436	3	degradation	degradation	NN
cord-254492-42d77vxf	436	4	of	of	IN
cord-254492-42d77vxf	436	5	mitochondrial	mitochondrial	JJ
cord-254492-42d77vxf	436	6	antiviral	antiviral	JJ
cord-254492-42d77vxf	436	7	signaling	signaling	NN
cord-254492-42d77vxf	436	8	(	(	-LRB-
cord-254492-42d77vxf	436	9	MAVS	MAVS	NNP
cord-254492-42d77vxf	436	10	)	)	-RRB-
cord-254492-42d77vxf	437	1	TRIM27	TRIM27	VBG
cord-254492-42d77vxf	437	2	negatively	negatively	RB
cord-254492-42d77vxf	437	3	regulates	regulate	VBZ
cord-254492-42d77vxf	437	4	NOD2	NOD2	NNS
cord-254492-42d77vxf	437	5	by	by	IN
cord-254492-42d77vxf	437	6	ubiquitination	ubiquitination	NN
cord-254492-42d77vxf	437	7	and	and	CC
cord-254492-42d77vxf	437	8	proteasomal	proteasomal	JJ
cord-254492-42d77vxf	437	9	degradation	degradation	NN
cord-254492-42d77vxf	438	1	Ribose	ribose	NN
cord-254492-42d77vxf	438	2	2′-O	2′-o	CD
cord-254492-42d77vxf	438	3	-	-	HYPH
cord-254492-42d77vxf	438	4	methylation	methylation	NN
cord-254492-42d77vxf	438	5	provides	provide	VBZ
cord-254492-42d77vxf	438	6	a	a	DT
cord-254492-42d77vxf	438	7	molecular	molecular	JJ
cord-254492-42d77vxf	438	8	signature	signature	NN
cord-254492-42d77vxf	438	9	for	for	IN
cord-254492-42d77vxf	438	10	the	the	DT
cord-254492-42d77vxf	438	11	distinction	distinction	NN
cord-254492-42d77vxf	438	12	of	of	IN
cord-254492-42d77vxf	438	13	self	self	NN
cord-254492-42d77vxf	438	14	and	and	CC
cord-254492-42d77vxf	438	15	non	non	JJ
cord-254492-42d77vxf	438	16	-	-	JJ
cord-254492-42d77vxf	438	17	self	self	JJ
cord-254492-42d77vxf	438	18	mRNA	mrna	NN
cord-254492-42d77vxf	438	19	dependent	dependent	JJ
cord-254492-42d77vxf	438	20	on	on	IN
cord-254492-42d77vxf	438	21	the	the	DT
cord-254492-42d77vxf	438	22	RNA	RNA	NNP
cord-254492-42d77vxf	438	23	sensor	sensor	NN
cord-254492-42d77vxf	439	1	Mda5	Mda5	NNS
cord-254492-42d77vxf	440	1	We	-PRON-	PRP
cord-254492-42d77vxf	440	2	are	be	VBP
cord-254492-42d77vxf	440	3	grateful	grateful	JJ
cord-254492-42d77vxf	440	4	to	to	IN
cord-254492-42d77vxf	440	5	Dr.	Dr.	NNP
cord-254492-42d77vxf	440	6	Sarah	Sarah	NNP
cord-254492-42d77vxf	440	7	Atkinson	Atkinson	NNP
cord-254492-42d77vxf	440	8	for	for	IN
cord-254492-42d77vxf	440	9	critical	critical	JJ
cord-254492-42d77vxf	440	10	review	review	NN
cord-254492-42d77vxf	440	11	of	of	IN
cord-254492-42d77vxf	440	12	the	the	DT
cord-254492-42d77vxf	440	13	manuscript	manuscript	NN
cord-254492-42d77vxf	440	14	.	.	.
cord-254492-42d77vxf	441	1	N.A.	N.A.	NNP
cord-254492-42d77vxf	441	2	Borg	Borg	NNP
cord-254492-42d77vxf	441	3	is	be	VBZ
cord-254492-42d77vxf	441	4	an	an	DT
cord-254492-42d77vxf	441	5	Australian	Australian	NNP
cord-254492-42d77vxf	441	6	Research	Research	NNP
cord-254492-42d77vxf	441	7	Council	Council	NNP
cord-254492-42d77vxf	441	8	(	(	-LRB-
cord-254492-42d77vxf	441	9	ARC	ARC	NNP
cord-254492-42d77vxf	441	10	)	)	-RRB-
cord-254492-42d77vxf	442	1	Future	future	JJ
cord-254492-42d77vxf	442	2	Fellow	fellow	NN
cord-254492-42d77vxf	442	3	(	(	-LRB-
cord-254492-42d77vxf	442	4	FT110100223	ft110100223	NN
cord-254492-42d77vxf	442	5	)	)	-RRB-
cord-254492-42d77vxf	442	6	.	.	.
cord-254492-42d77vxf	443	1	The	the	DT
cord-254492-42d77vxf	443	2	authors	author	NNS
cord-254492-42d77vxf	443	3	declare	declare	VBP
cord-254492-42d77vxf	443	4	no	no	DT
cord-254492-42d77vxf	443	5	competing	compete	VBG
cord-254492-42d77vxf	443	6	financial	financial	JJ
cord-254492-42d77vxf	443	7	interests	interest	NNS
cord-254492-42d77vxf	443	8	.	.	.
cord-254492-42d77vxf	444	1	Accepted	accept	VBN
cord-254492-42d77vxf	444	2	:	:	:
cord-254492-42d77vxf	444	3	2	2	CD
cord-254492-42d77vxf	444	4	December	December	NNP
cord-254492-42d77vxf	444	5	2015	2015	CD