id	sid	tid	token	lemma	pos
cord-254895-ym0jsir5	1	1	key	key	NN
cord-254895-ym0jsir5	1	2	:	:	:
cord-254895-ym0jsir5	2	1	cord-254895-ym0jsir5	cord-254895-ym0jsir5	NNP
cord-254895-ym0jsir5	2	2	authors	author	NNS
cord-254895-ym0jsir5	2	3	:	:	:
cord-254895-ym0jsir5	2	4	Eisenächer	Eisenächer	NNP
cord-254895-ym0jsir5	2	5	,	,	,
cord-254895-ym0jsir5	2	6	Katharina	Katharina	NNP
cord-254895-ym0jsir5	2	7	;	;	:
cord-254895-ym0jsir5	2	8	Steinberg	Steinberg	NNP
cord-254895-ym0jsir5	2	9	,	,	,
cord-254895-ym0jsir5	2	10	Christian	Christian	NNP
cord-254895-ym0jsir5	2	11	;	;	:
cord-254895-ym0jsir5	2	12	Reindl	Reindl	NNP
cord-254895-ym0jsir5	2	13	,	,	,
cord-254895-ym0jsir5	2	14	Wolfgang	Wolfgang	NNP
cord-254895-ym0jsir5	2	15	;	;	:
cord-254895-ym0jsir5	2	16	Krug	Krug	NNP
cord-254895-ym0jsir5	2	17	,	,	,
cord-254895-ym0jsir5	2	18	Anne	Anne	NNP
cord-254895-ym0jsir5	2	19	title	title	NN
cord-254895-ym0jsir5	2	20	:	:	:
cord-254895-ym0jsir5	2	21	The	the	DT
cord-254895-ym0jsir5	2	22	role	role	NN
cord-254895-ym0jsir5	2	23	of	of	IN
cord-254895-ym0jsir5	2	24	viral	viral	JJ
cord-254895-ym0jsir5	2	25	nucleic	nucleic	JJ
cord-254895-ym0jsir5	2	26	acid	acid	NN
cord-254895-ym0jsir5	2	27	recognition	recognition	NN
cord-254895-ym0jsir5	2	28	in	in	IN
cord-254895-ym0jsir5	2	29	dendritic	dendritic	JJ
cord-254895-ym0jsir5	2	30	cells	cell	NNS
cord-254895-ym0jsir5	2	31	for	for	IN
cord-254895-ym0jsir5	2	32	innate	innate	JJ
cord-254895-ym0jsir5	2	33	and	and	CC
cord-254895-ym0jsir5	2	34	adaptive	adaptive	JJ
cord-254895-ym0jsir5	2	35	antiviral	antiviral	JJ
cord-254895-ym0jsir5	2	36	immunity	immunity	NN
cord-254895-ym0jsir5	2	37	date	date	NN
cord-254895-ym0jsir5	2	38	:	:	:
cord-254895-ym0jsir5	2	39	2008	2008	CD
cord-254895-ym0jsir5	2	40	-	-	SYM
cord-254895-ym0jsir5	2	41	01	01	CD
cord-254895-ym0jsir5	2	42	-	-	SYM
cord-254895-ym0jsir5	2	43	18	18	CD
cord-254895-ym0jsir5	2	44	journal	journal	NN
cord-254895-ym0jsir5	2	45	:	:	:
cord-254895-ym0jsir5	3	1	Immunobiology	Immunobiology	NNP
cord-254895-ym0jsir5	3	2	DOI	DOI	NNP
cord-254895-ym0jsir5	3	3	:	:	:
cord-254895-ym0jsir5	3	4	10.1016	10.1016	CD
cord-254895-ym0jsir5	3	5	/	/	SYM
cord-254895-ym0jsir5	3	6	j.imbio.2007.09.007	j.imbio.2007.09.007	NN
cord-254895-ym0jsir5	3	7	sha	sha	NN
cord-254895-ym0jsir5	3	8	:	:	:
cord-254895-ym0jsir5	3	9	5f5b18b0f7c14a78216c49da9a13712161fe5750	5f5b18b0f7c14a78216c49da9a13712161fe5750	CD
cord-254895-ym0jsir5	3	10	doc_id	doc_id	CD
cord-254895-ym0jsir5	3	11	:	:	:
cord-254895-ym0jsir5	3	12	254895	254895	CD
cord-254895-ym0jsir5	3	13	cord_uid	cord_uid	NNS
cord-254895-ym0jsir5	3	14	:	:	:
cord-254895-ym0jsir5	4	1	ym0jsir5	ym0jsir5	NNP
cord-254895-ym0jsir5	4	2	Abstract	Abstract	NNP
cord-254895-ym0jsir5	4	3	Dendritic	Dendritic	NNP
cord-254895-ym0jsir5	4	4	cells	cell	NNS
cord-254895-ym0jsir5	4	5	which	which	WDT
cord-254895-ym0jsir5	4	6	are	be	VBP
cord-254895-ym0jsir5	4	7	located	locate	VBN
cord-254895-ym0jsir5	4	8	at	at	IN
cord-254895-ym0jsir5	4	9	the	the	DT
cord-254895-ym0jsir5	4	10	interface	interface	NN
cord-254895-ym0jsir5	4	11	of	of	IN
cord-254895-ym0jsir5	4	12	innate	innate	JJ
cord-254895-ym0jsir5	4	13	and	and	CC
cord-254895-ym0jsir5	4	14	adaptive	adaptive	JJ
cord-254895-ym0jsir5	4	15	immunity	immunity	NN
cord-254895-ym0jsir5	4	16	are	be	VBP
cord-254895-ym0jsir5	4	17	targets	target	NNS
cord-254895-ym0jsir5	4	18	for	for	IN
cord-254895-ym0jsir5	4	19	infection	infection	NN
cord-254895-ym0jsir5	4	20	by	by	IN
cord-254895-ym0jsir5	4	21	many	many	JJ
cord-254895-ym0jsir5	4	22	different	different	JJ
cord-254895-ym0jsir5	4	23	DNA	dna	NN
cord-254895-ym0jsir5	4	24	and	and	CC
cord-254895-ym0jsir5	4	25	RNA	RNA	NNP
cord-254895-ym0jsir5	4	26	viruses	virus	NNS
cord-254895-ym0jsir5	4	27	.	.	.
cord-254895-ym0jsir5	5	1	Dendritic	dendritic	JJ
cord-254895-ym0jsir5	5	2	cell	cell	NN
cord-254895-ym0jsir5	5	3	subpopulations	subpopulation	NNS
cord-254895-ym0jsir5	5	4	express	express	VBP
cord-254895-ym0jsir5	5	5	specific	specific	JJ
cord-254895-ym0jsir5	5	6	nucleic	nucleic	JJ
cord-254895-ym0jsir5	5	7	acid	acid	NN
cord-254895-ym0jsir5	5	8	recognition	recognition	NN
cord-254895-ym0jsir5	5	9	receptors	receptor	NNS
cord-254895-ym0jsir5	5	10	belonging	belong	VBG
cord-254895-ym0jsir5	5	11	to	to	IN
cord-254895-ym0jsir5	5	12	the	the	DT
cord-254895-ym0jsir5	5	13	Toll	Toll	NNP
cord-254895-ym0jsir5	5	14	-	-	HYPH
cord-254895-ym0jsir5	5	15	like	like	JJ
cord-254895-ym0jsir5	5	16	receptor	receptor	NN
cord-254895-ym0jsir5	5	17	family	family	NN
cord-254895-ym0jsir5	5	18	(	(	-LRB-
cord-254895-ym0jsir5	5	19	TLR3	TLR3	NNP
cord-254895-ym0jsir5	5	20	,	,	,
cord-254895-ym0jsir5	5	21	7	7	CD
cord-254895-ym0jsir5	5	22	,	,	,
cord-254895-ym0jsir5	5	23	8	8	CD
cord-254895-ym0jsir5	5	24	,	,	,
cord-254895-ym0jsir5	5	25	9	9	CD
cord-254895-ym0jsir5	5	26	)	)	-RRB-
cord-254895-ym0jsir5	5	27	and	and	CC
cord-254895-ym0jsir5	5	28	the	the	DT
cord-254895-ym0jsir5	5	29	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	5	30	RNA	RNA	NNP
cord-254895-ym0jsir5	5	31	helicase	helicase	NN
cord-254895-ym0jsir5	5	32	family	family	NN
cord-254895-ym0jsir5	5	33	(	(	-LRB-
cord-254895-ym0jsir5	5	34	RIG	rig	NN
cord-254895-ym0jsir5	5	35	-	-	HYPH
cord-254895-ym0jsir5	5	36	I	I	NNP
cord-254895-ym0jsir5	5	37	,	,	,
cord-254895-ym0jsir5	5	38	MDA5	MDA5	NNP
cord-254895-ym0jsir5	5	39	,	,	,
cord-254895-ym0jsir5	5	40	LGP2	LGP2	NNP
cord-254895-ym0jsir5	5	41	)	)	-RRB-
cord-254895-ym0jsir5	5	42	.	.	.
cord-254895-ym0jsir5	6	1	Activation	activation	NN
cord-254895-ym0jsir5	6	2	of	of	IN
cord-254895-ym0jsir5	6	3	dendritic	dendritic	JJ
cord-254895-ym0jsir5	6	4	cells	cell	NNS
cord-254895-ym0jsir5	6	5	by	by	IN
cord-254895-ym0jsir5	6	6	viral	viral	JJ
cord-254895-ym0jsir5	6	7	DNA	DNA	NNP
cord-254895-ym0jsir5	6	8	and	and	CC
cord-254895-ym0jsir5	6	9	RNA	RNA	NNP
cord-254895-ym0jsir5	6	10	via	via	IN
cord-254895-ym0jsir5	6	11	these	these	DT
cord-254895-ym0jsir5	6	12	receptors	receptor	NNS
cord-254895-ym0jsir5	6	13	is	be	VBZ
cord-254895-ym0jsir5	6	14	essential	essential	JJ
cord-254895-ym0jsir5	6	15	for	for	IN
cord-254895-ym0jsir5	6	16	triggering	trigger	VBG
cord-254895-ym0jsir5	6	17	the	the	DT
cord-254895-ym0jsir5	6	18	innate	innate	JJ
cord-254895-ym0jsir5	6	19	antiviral	antiviral	JJ
cord-254895-ym0jsir5	6	20	immune	immune	JJ
cord-254895-ym0jsir5	6	21	response	response	NN
cord-254895-ym0jsir5	6	22	and	and	CC
cord-254895-ym0jsir5	6	23	shaping	shape	VBG
cord-254895-ym0jsir5	6	24	the	the	DT
cord-254895-ym0jsir5	6	25	ensuing	ensue	VBG
cord-254895-ym0jsir5	6	26	adaptive	adaptive	JJ
cord-254895-ym0jsir5	6	27	antiviral	antiviral	JJ
cord-254895-ym0jsir5	6	28	immunity	immunity	NN
cord-254895-ym0jsir5	6	29	.	.	.
cord-254895-ym0jsir5	7	1	This	this	DT
cord-254895-ym0jsir5	7	2	review	review	NN
cord-254895-ym0jsir5	7	3	will	will	MD
cord-254895-ym0jsir5	7	4	summarize	summarize	VB
cord-254895-ym0jsir5	7	5	our	-PRON-	PRP$
cord-254895-ym0jsir5	7	6	current	current	JJ
cord-254895-ym0jsir5	7	7	knowledge	knowledge	NN
cord-254895-ym0jsir5	7	8	of	of	IN
cord-254895-ym0jsir5	7	9	viral	viral	JJ
cord-254895-ym0jsir5	7	10	nucleic	nucleic	JJ
cord-254895-ym0jsir5	7	11	acid	acid	NN
cord-254895-ym0jsir5	7	12	recognition	recognition	NN
cord-254895-ym0jsir5	7	13	and	and	CC
cord-254895-ym0jsir5	7	14	signaling	signaling	NN
cord-254895-ym0jsir5	7	15	by	by	IN
cord-254895-ym0jsir5	7	16	Toll	toll	NN
cord-254895-ym0jsir5	7	17	-	-	HYPH
cord-254895-ym0jsir5	7	18	like	like	JJ
cord-254895-ym0jsir5	7	19	receptors	receptor	NNS
cord-254895-ym0jsir5	7	20	and	and	CC
cord-254895-ym0jsir5	7	21	RNA	RNA	NNP
cord-254895-ym0jsir5	7	22	helicases	helicase	NNS
cord-254895-ym0jsir5	7	23	focusing	focus	VBG
cord-254895-ym0jsir5	7	24	on	on	IN
cord-254895-ym0jsir5	7	25	recent	recent	JJ
cord-254895-ym0jsir5	7	26	evidence	evidence	NN
cord-254895-ym0jsir5	7	27	for	for	IN
cord-254895-ym0jsir5	7	28	their	-PRON-	PRP$
cord-254895-ym0jsir5	7	29	specific	specific	JJ
cord-254895-ym0jsir5	7	30	functions	function	NNS
cord-254895-ym0jsir5	7	31	in	in	IN
cord-254895-ym0jsir5	7	32	antiviral	antiviral	JJ
cord-254895-ym0jsir5	7	33	defense	defense	NN
cord-254895-ym0jsir5	7	34	in	in	IN
cord-254895-ym0jsir5	7	35	vivo	vivo	NNP
cord-254895-ym0jsir5	7	36	.	.	.
cord-254895-ym0jsir5	8	1	Dendritic	dendritic	JJ
cord-254895-ym0jsir5	8	2	cells	cell	NNS
cord-254895-ym0jsir5	8	3	(	(	-LRB-
cord-254895-ym0jsir5	8	4	DCs	DCs	NNP
cord-254895-ym0jsir5	8	5	)	)	-RRB-
cord-254895-ym0jsir5	8	6	,	,	,
cord-254895-ym0jsir5	8	7	which	which	WDT
cord-254895-ym0jsir5	8	8	are	be	VBP
cord-254895-ym0jsir5	8	9	present	present	JJ
cord-254895-ym0jsir5	8	10	in	in	IN
cord-254895-ym0jsir5	8	11	the	the	DT
cord-254895-ym0jsir5	8	12	tissues	tissue	NNS
cord-254895-ym0jsir5	8	13	of	of	IN
cord-254895-ym0jsir5	8	14	all	all	DT
cord-254895-ym0jsir5	8	15	organs	organ	NNS
cord-254895-ym0jsir5	8	16	as	as	RB
cord-254895-ym0jsir5	8	17	well	well	RB
cord-254895-ym0jsir5	8	18	as	as	IN
cord-254895-ym0jsir5	8	19	in	in	IN
cord-254895-ym0jsir5	8	20	the	the	DT
cord-254895-ym0jsir5	8	21	circulation	circulation	NN
cord-254895-ym0jsir5	8	22	and	and	CC
cord-254895-ym0jsir5	8	23	in	in	IN
cord-254895-ym0jsir5	8	24	lymphatic	lymphatic	JJ
cord-254895-ym0jsir5	8	25	organs	organ	NNS
cord-254895-ym0jsir5	8	26	,	,	,
cord-254895-ym0jsir5	8	27	are	be	VBP
cord-254895-ym0jsir5	8	28	targets	target	NNS
cord-254895-ym0jsir5	8	29	for	for	IN
cord-254895-ym0jsir5	8	30	infection	infection	NN
cord-254895-ym0jsir5	8	31	by	by	IN
cord-254895-ym0jsir5	8	32	many	many	JJ
cord-254895-ym0jsir5	8	33	different	different	JJ
cord-254895-ym0jsir5	8	34	viruses	virus	NNS
cord-254895-ym0jsir5	8	35	.	.	.
cord-254895-ym0jsir5	9	1	Viruses	virus	NNS
cord-254895-ym0jsir5	9	2	entering	enter	VBG
cord-254895-ym0jsir5	9	3	the	the	DT
cord-254895-ym0jsir5	9	4	body	body	NN
cord-254895-ym0jsir5	9	5	through	through	IN
cord-254895-ym0jsir5	9	6	epithelial	epithelial	JJ
cord-254895-ym0jsir5	9	7	surfaces	surface	NNS
cord-254895-ym0jsir5	9	8	or	or	CC
cord-254895-ym0jsir5	9	9	directly	directly	RB
cord-254895-ym0jsir5	9	10	via	via	IN
cord-254895-ym0jsir5	9	11	the	the	DT
cord-254895-ym0jsir5	9	12	blood	blood	NN
cord-254895-ym0jsir5	9	13	stream	stream	NN
cord-254895-ym0jsir5	9	14	encounter	encounter	NN
cord-254895-ym0jsir5	9	15	DCs	dc	NNS
cord-254895-ym0jsir5	9	16	at	at	IN
cord-254895-ym0jsir5	9	17	early	early	JJ
cord-254895-ym0jsir5	9	18	time	time	NN
cord-254895-ym0jsir5	9	19	points	point	NNS
cord-254895-ym0jsir5	9	20	during	during	IN
cord-254895-ym0jsir5	9	21	infection	infection	NN
cord-254895-ym0jsir5	9	22	.	.	.
cord-254895-ym0jsir5	10	1	DCs	DCs	NNP
cord-254895-ym0jsir5	10	2	are	be	VBP
cord-254895-ym0jsir5	10	3	unique	unique	JJ
cord-254895-ym0jsir5	10	4	in	in	IN
cord-254895-ym0jsir5	10	5	their	-PRON-	PRP$
cord-254895-ym0jsir5	10	6	capacity	capacity	NN
cord-254895-ym0jsir5	10	7	to	to	TO
cord-254895-ym0jsir5	10	8	migrate	migrate	VB
cord-254895-ym0jsir5	10	9	from	from	IN
cord-254895-ym0jsir5	10	10	the	the	DT
cord-254895-ym0jsir5	10	11	periphery	periphery	NN
cord-254895-ym0jsir5	10	12	to	to	IN
cord-254895-ym0jsir5	10	13	lymphoid	lymphoid	JJ
cord-254895-ym0jsir5	10	14	organs	organ	NNS
cord-254895-ym0jsir5	10	15	or	or	CC
cord-254895-ym0jsir5	10	16	from	from	IN
cord-254895-ym0jsir5	10	17	the	the	DT
cord-254895-ym0jsir5	10	18	blood	blood	NN
cord-254895-ym0jsir5	10	19	stream	stream	NN
cord-254895-ym0jsir5	10	20	into	into	IN
cord-254895-ym0jsir5	10	21	lymphatic	lymphatic	NN
cord-254895-ym0jsir5	10	22	and	and	CC
cord-254895-ym0jsir5	10	23	peripheral	peripheral	JJ
cord-254895-ym0jsir5	10	24	tissues	tissue	NNS
cord-254895-ym0jsir5	10	25	.	.	.
cord-254895-ym0jsir5	11	1	Virus	virus	NN
cord-254895-ym0jsir5	11	2	-	-	HYPH
cord-254895-ym0jsir5	11	3	infected	infect	VBN
cord-254895-ym0jsir5	11	4	DCs	dc	NNS
cord-254895-ym0jsir5	11	5	can	can	MD
cord-254895-ym0jsir5	11	6	therefore	therefore	RB
cord-254895-ym0jsir5	11	7	transport	transport	VB
cord-254895-ym0jsir5	11	8	viruses	virus	NNS
cord-254895-ym0jsir5	11	9	to	to	IN
cord-254895-ym0jsir5	11	10	other	other	JJ
cord-254895-ym0jsir5	11	11	parts	part	NNS
cord-254895-ym0jsir5	11	12	of	of	IN
cord-254895-ym0jsir5	11	13	the	the	DT
cord-254895-ym0jsir5	11	14	organism	organism	NN
cord-254895-ym0jsir5	11	15	and	and	CC
cord-254895-ym0jsir5	11	16	thus	thus	RB
cord-254895-ym0jsir5	11	17	contribute	contribute	VB
cord-254895-ym0jsir5	11	18	to	to	IN
cord-254895-ym0jsir5	11	19	the	the	DT
cord-254895-ym0jsir5	11	20	spreading	spreading	NN
cord-254895-ym0jsir5	11	21	of	of	IN
cord-254895-ym0jsir5	11	22	the	the	DT
cord-254895-ym0jsir5	11	23	pathogens	pathogen	NNS
cord-254895-ym0jsir5	11	24	to	to	IN
cord-254895-ym0jsir5	11	25	many	many	JJ
cord-254895-ym0jsir5	11	26	organs	organ	NNS
cord-254895-ym0jsir5	11	27	during	during	IN
cord-254895-ym0jsir5	11	28	systemic	systemic	JJ
cord-254895-ym0jsir5	11	29	infection	infection	NN
cord-254895-ym0jsir5	11	30	.	.	.
cord-254895-ym0jsir5	12	1	However	however	RB
cord-254895-ym0jsir5	12	2	,	,	,
cord-254895-ym0jsir5	12	3	DCs	dc	NNS
cord-254895-ym0jsir5	12	4	are	be	VBP
cord-254895-ym0jsir5	12	5	also	also	RB
cord-254895-ym0jsir5	12	6	equipped	equip	VBN
cord-254895-ym0jsir5	12	7	with	with	IN
cord-254895-ym0jsir5	12	8	a	a	DT
cord-254895-ym0jsir5	12	9	range	range	NN
cord-254895-ym0jsir5	12	10	of	of	IN
cord-254895-ym0jsir5	12	11	receptors	receptor	NNS
cord-254895-ym0jsir5	12	12	(	(	-LRB-
cord-254895-ym0jsir5	12	13	for	for	IN
cord-254895-ym0jsir5	12	14	example	example	NN
cord-254895-ym0jsir5	12	15	Toll	Toll	NNP
cord-254895-ym0jsir5	12	16	-	-	HYPH
cord-254895-ym0jsir5	12	17	like	like	JJ
cord-254895-ym0jsir5	12	18	receptors	receptor	NNS
cord-254895-ym0jsir5	12	19	,	,	,
cord-254895-ym0jsir5	12	20	TLRs	TLRs	NNP
cord-254895-ym0jsir5	12	21	)	)	-RRB-
cord-254895-ym0jsir5	12	22	that	that	WDT
cord-254895-ym0jsir5	12	23	recognize	recognize	VBP
cord-254895-ym0jsir5	12	24	conserved	conserve	VBN
cord-254895-ym0jsir5	12	25	molecular	molecular	JJ
cord-254895-ym0jsir5	12	26	patterns	pattern	NNS
cord-254895-ym0jsir5	12	27	of	of	IN
cord-254895-ym0jsir5	12	28	viruseseither	viruseseither	JJ
cord-254895-ym0jsir5	12	29	viral	viral	JJ
cord-254895-ym0jsir5	12	30	proteins	protein	NNS
cord-254895-ym0jsir5	12	31	or	or	CC
cord-254895-ym0jsir5	12	32	viral	viral	JJ
cord-254895-ym0jsir5	12	33	nucleic	nucleic	JJ
cord-254895-ym0jsir5	12	34	acids	acid	NNS
cord-254895-ym0jsir5	12	35	with	with	IN
cord-254895-ym0jsir5	12	36	specific	specific	JJ
cord-254895-ym0jsir5	12	37	distinguishing	distinguishing	JJ
cord-254895-ym0jsir5	12	38	features	feature	NNS
cord-254895-ym0jsir5	12	39	(	(	-LRB-
cord-254895-ym0jsir5	12	40	Lund	Lund	NNP
cord-254895-ym0jsir5	12	41	et	et	NNP
cord-254895-ym0jsir5	12	42	al	al	NNP
cord-254895-ym0jsir5	12	43	.	.	NNP
cord-254895-ym0jsir5	12	44	,	,	,
cord-254895-ym0jsir5	12	45	2003	2003	CD
cord-254895-ym0jsir5	12	46	;	;	:
cord-254895-ym0jsir5	12	47	Krug	Krug	NNP
cord-254895-ym0jsir5	12	48	et	et	NNP
cord-254895-ym0jsir5	12	49	al	al	NNP
cord-254895-ym0jsir5	12	50	.	.	NNP
cord-254895-ym0jsir5	12	51	,	,	,
cord-254895-ym0jsir5	12	52	2004a	2004a	CD
cord-254895-ym0jsir5	12	53	,	,	,
cord-254895-ym0jsir5	12	54	b	b	LS
cord-254895-ym0jsir5	12	55	;	;	:
cord-254895-ym0jsir5	12	56	Schulz	Schulz	NNP
cord-254895-ym0jsir5	12	57	et	et	NNP
cord-254895-ym0jsir5	12	58	al	al	NNP
cord-254895-ym0jsir5	12	59	.	.	NNP
cord-254895-ym0jsir5	12	60	,	,	,
cord-254895-ym0jsir5	12	61	2005	2005	CD
cord-254895-ym0jsir5	12	62	)	)	-RRB-
cord-254895-ym0jsir5	12	63	.	.	.
cord-254895-ym0jsir5	13	1	Triggering	trigger	VBG
cord-254895-ym0jsir5	13	2	of	of	IN
cord-254895-ym0jsir5	13	3	these	these	DT
cord-254895-ym0jsir5	13	4	pattern	pattern	NN
cord-254895-ym0jsir5	13	5	recognition	recognition	NN
cord-254895-ym0jsir5	13	6	receptors	receptor	NNS
cord-254895-ym0jsir5	13	7	in	in	IN
cord-254895-ym0jsir5	13	8	virus	virus	NN
cord-254895-ym0jsir5	13	9	-	-	HYPH
cord-254895-ym0jsir5	13	10	infected	infect	VBN
cord-254895-ym0jsir5	13	11	DCs	dc	NNS
cord-254895-ym0jsir5	13	12	initiates	initiate	VBZ
cord-254895-ym0jsir5	13	13	the	the	DT
cord-254895-ym0jsir5	13	14	innate	innate	JJ
cord-254895-ym0jsir5	13	15	antiviral	antiviral	JJ
cord-254895-ym0jsir5	13	16	immune	immune	JJ
cord-254895-ym0jsir5	13	17	response	response	NN
cord-254895-ym0jsir5	13	18	,	,	,
cord-254895-ym0jsir5	13	19	which	which	WDT
cord-254895-ym0jsir5	13	20	is	be	VBZ
cord-254895-ym0jsir5	13	21	essential	essential	JJ
cord-254895-ym0jsir5	13	22	for	for	IN
cord-254895-ym0jsir5	13	23	limiting	limit	VBG
cord-254895-ym0jsir5	13	24	further	further	JJ
cord-254895-ym0jsir5	13	25	viral	viral	JJ
cord-254895-ym0jsir5	13	26	dissemination	dissemination	NN
cord-254895-ym0jsir5	13	27	(	(	-LRB-
cord-254895-ym0jsir5	13	28	Dalod	Dalod	NNP
cord-254895-ym0jsir5	13	29	et	et	FW
cord-254895-ym0jsir5	13	30	al	al	NNP
cord-254895-ym0jsir5	13	31	.	.	NNP
cord-254895-ym0jsir5	13	32	,	,	,
cord-254895-ym0jsir5	13	33	2003	2003	CD
cord-254895-ym0jsir5	13	34	;	;	:
cord-254895-ym0jsir5	13	35	Krug	Krug	NNP
cord-254895-ym0jsir5	13	36	et	et	NNP
cord-254895-ym0jsir5	13	37	al	al	NNP
cord-254895-ym0jsir5	13	38	.	.	NNP
cord-254895-ym0jsir5	13	39	,	,	,
cord-254895-ym0jsir5	13	40	2004a	2004a	CD
cord-254895-ym0jsir5	13	41	)	)	-RRB-
cord-254895-ym0jsir5	13	42	.	.	.
cord-254895-ym0jsir5	14	1	The	the	DT
cord-254895-ym0jsir5	14	2	DCs	dc	NNS
cord-254895-ym0jsir5	14	3	themselves	-PRON-	PRP
cord-254895-ym0jsir5	14	4	produce	produce	VBP
cord-254895-ym0jsir5	14	5	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	14	6	cytokines	cytokine	NNS
cord-254895-ym0jsir5	14	7	and	and	CC
cord-254895-ym0jsir5	14	8	antiviral	antiviral	JJ
cord-254895-ym0jsir5	14	9	interferons	interferon	NNS
cord-254895-ym0jsir5	14	10	in	in	IN
cord-254895-ym0jsir5	14	11	response	response	NN
cord-254895-ym0jsir5	14	12	to	to	IN
cord-254895-ym0jsir5	14	13	viral	viral	JJ
cord-254895-ym0jsir5	14	14	infection	infection	NN
cord-254895-ym0jsir5	14	15	.	.	.
cord-254895-ym0jsir5	15	1	In	in	IN
cord-254895-ym0jsir5	15	2	addition	addition	NN
cord-254895-ym0jsir5	15	3	DCs	DCs	NNP
cord-254895-ym0jsir5	15	4	express	express	NNP
cord-254895-ym0jsir5	15	5	ligands	ligand	NNS
cord-254895-ym0jsir5	15	6	for	for	IN
cord-254895-ym0jsir5	15	7	activating	activate	VBG
cord-254895-ym0jsir5	15	8	receptors	receptor	NNS
cord-254895-ym0jsir5	15	9	on	on	IN
cord-254895-ym0jsir5	15	10	the	the	DT
cord-254895-ym0jsir5	15	11	surface	surface	NN
cord-254895-ym0jsir5	15	12	of	of	IN
cord-254895-ym0jsir5	15	13	natural	natural	JJ
cord-254895-ym0jsir5	15	14	killer	killer	NN
cord-254895-ym0jsir5	15	15	(	(	-LRB-
cord-254895-ym0jsir5	15	16	NK	NK	NNP
cord-254895-ym0jsir5	15	17	)	)	-RRB-
cord-254895-ym0jsir5	15	18	cells	cell	NNS
cord-254895-ym0jsir5	15	19	leading	lead	VBG
cord-254895-ym0jsir5	15	20	to	to	IN
cord-254895-ym0jsir5	15	21	activation	activation	NN
cord-254895-ym0jsir5	15	22	of	of	IN
cord-254895-ym0jsir5	15	23	this	this	DT
cord-254895-ym0jsir5	15	24	innate	innate	JJ
cord-254895-ym0jsir5	15	25	antiviral	antiviral	JJ
cord-254895-ym0jsir5	15	26	effector	effector	NN
cord-254895-ym0jsir5	15	27	cell	cell	NN
cord-254895-ym0jsir5	15	28	type	type	NN
cord-254895-ym0jsir5	15	29	(	(	-LRB-
cord-254895-ym0jsir5	15	30	Andoniou	Andoniou	NNP
cord-254895-ym0jsir5	15	31	et	et	NNP
cord-254895-ym0jsir5	15	32	al	al	NNP
cord-254895-ym0jsir5	15	33	.	.	NNP
cord-254895-ym0jsir5	15	34	,	,	,
cord-254895-ym0jsir5	15	35	2005	2005	CD
cord-254895-ym0jsir5	15	36	)	)	-RRB-
cord-254895-ym0jsir5	15	37	.	.	.
cord-254895-ym0jsir5	16	1	DCs	DCs	NNP
cord-254895-ym0jsir5	16	2	are	be	VBP
cord-254895-ym0jsir5	16	3	experts	expert	NNS
cord-254895-ym0jsir5	16	4	in	in	IN
cord-254895-ym0jsir5	16	5	the	the	DT
cord-254895-ym0jsir5	16	6	processing	processing	NN
cord-254895-ym0jsir5	16	7	and	and	CC
cord-254895-ym0jsir5	16	8	presentation	presentation	NN
cord-254895-ym0jsir5	16	9	of	of	IN
cord-254895-ym0jsir5	16	10	viral	viral	JJ
cord-254895-ym0jsir5	16	11	antigens	antigen	NNS
cord-254895-ym0jsir5	16	12	on	on	IN
cord-254895-ym0jsir5	16	13	MHC	MHC	NNP
cord-254895-ym0jsir5	16	14	class	class	NN
cord-254895-ym0jsir5	16	15	I	-PRON-	PRP
cord-254895-ym0jsir5	16	16	as	as	RB
cord-254895-ym0jsir5	16	17	well	well	RB
cord-254895-ym0jsir5	16	18	as	as	IN
cord-254895-ym0jsir5	16	19	crosspresentation	crosspresentation	NN
cord-254895-ym0jsir5	16	20	on	on	IN
cord-254895-ym0jsir5	16	21	MHC	MHC	NNP
cord-254895-ym0jsir5	16	22	class	class	NN
cord-254895-ym0jsir5	16	23	II	II	NNP
cord-254895-ym0jsir5	16	24	.	.	.
cord-254895-ym0jsir5	17	1	The	the	DT
cord-254895-ym0jsir5	17	2	antigen	antigen	NN
cord-254895-ym0jsir5	17	3	presenting	present	VBG
cord-254895-ym0jsir5	17	4	function	function	NN
cord-254895-ym0jsir5	17	5	of	of	IN
cord-254895-ym0jsir5	17	6	DCs	DCs	NNP
cord-254895-ym0jsir5	17	7	is	be	VBZ
cord-254895-ym0jsir5	17	8	critically	critically	RB
cord-254895-ym0jsir5	17	9	involved	involve	VBN
cord-254895-ym0jsir5	17	10	in	in	IN
cord-254895-ym0jsir5	17	11	the	the	DT
cord-254895-ym0jsir5	17	12	generation	generation	NN
cord-254895-ym0jsir5	17	13	of	of	IN
cord-254895-ym0jsir5	17	14	efficient	efficient	JJ
cord-254895-ym0jsir5	17	15	adaptive	adaptive	JJ
cord-254895-ym0jsir5	17	16	immunity	immunity	NN
cord-254895-ym0jsir5	17	17	against	against	IN
cord-254895-ym0jsir5	17	18	viruses	virus	NNS
cord-254895-ym0jsir5	17	19	(	(	-LRB-
cord-254895-ym0jsir5	17	20	Belz	Belz	NNP
cord-254895-ym0jsir5	17	21	et	et	NNP
cord-254895-ym0jsir5	17	22	al	al	NNP
cord-254895-ym0jsir5	17	23	.	.	NNP
cord-254895-ym0jsir5	17	24	,	,	,
cord-254895-ym0jsir5	17	25	2004	2004	CD
cord-254895-ym0jsir5	17	26	)	)	-RRB-
cord-254895-ym0jsir5	17	27	.	.	.
cord-254895-ym0jsir5	18	1	DC	DC	NNP
cord-254895-ym0jsir5	18	2	activation	activation	NN
cord-254895-ym0jsir5	18	3	by	by	IN
cord-254895-ym0jsir5	18	4	viruses	virus	NNS
cord-254895-ym0jsir5	18	5	via	via	IN
cord-254895-ym0jsir5	18	6	pattern	pattern	NN
cord-254895-ym0jsir5	18	7	recognition	recognition	NN
cord-254895-ym0jsir5	18	8	receptors	receptor	NNS
cord-254895-ym0jsir5	18	9	provides	provide	VBZ
cord-254895-ym0jsir5	18	10	the	the	DT
cord-254895-ym0jsir5	18	11	2nd	2nd	JJ
cord-254895-ym0jsir5	18	12	and	and	CC
cord-254895-ym0jsir5	18	13	3rd	3rd	JJ
cord-254895-ym0jsir5	18	14	signals	signal	NNS
cord-254895-ym0jsir5	18	15	required	require	VBN
cord-254895-ym0jsir5	18	16	for	for	IN
cord-254895-ym0jsir5	18	17	the	the	DT
cord-254895-ym0jsir5	18	18	priming	priming	NN
cord-254895-ym0jsir5	18	19	of	of	IN
cord-254895-ym0jsir5	18	20	naı¨ve	naı¨ve	NN
cord-254895-ym0jsir5	18	21	-	-	HYPH
cord-254895-ym0jsir5	18	22	specific	specific	JJ
cord-254895-ym0jsir5	18	23	T	t	NN
cord-254895-ym0jsir5	18	24	lymphocytes	lymphocyte	NNS
cord-254895-ym0jsir5	18	25	and	and	CC
cord-254895-ym0jsir5	18	26	their	-PRON-	PRP$
cord-254895-ym0jsir5	18	27	differentiation	differentiation	NN
cord-254895-ym0jsir5	18	28	into	into	IN
cord-254895-ym0jsir5	18	29	effector	effector	NN
cord-254895-ym0jsir5	18	30	T	t	NN
cord-254895-ym0jsir5	18	31	cells	cell	NNS
cord-254895-ym0jsir5	18	32	.	.	.
cord-254895-ym0jsir5	19	1	DC	DC	NNP
cord-254895-ym0jsir5	19	2	subpopulations	subpopulation	NNS
cord-254895-ym0jsir5	19	3	fulfill	fulfill	VBP
cord-254895-ym0jsir5	19	4	specific	specific	JJ
cord-254895-ym0jsir5	19	5	tasks	task	NNS
cord-254895-ym0jsir5	19	6	in	in	IN
cord-254895-ym0jsir5	19	7	the	the	DT
cord-254895-ym0jsir5	19	8	generation	generation	NN
cord-254895-ym0jsir5	19	9	of	of	IN
cord-254895-ym0jsir5	19	10	antiviral	antiviral	JJ
cord-254895-ym0jsir5	19	11	immune	immune	JJ
cord-254895-ym0jsir5	19	12	responses	response	NNS
cord-254895-ym0jsir5	19	13	.	.	.
cord-254895-ym0jsir5	20	1	Plasmacytoid	Plasmacytoid	NNP
cord-254895-ym0jsir5	20	2	DCs	DCs	NNP
cord-254895-ym0jsir5	20	3	(	(	-LRB-
cord-254895-ym0jsir5	20	4	pDC	pDC	NNP
cord-254895-ym0jsir5	20	5	)	)	-RRB-
cord-254895-ym0jsir5	20	6	,	,	,
cord-254895-ym0jsir5	20	7	which	which	WDT
cord-254895-ym0jsir5	20	8	have	have	VBP
cord-254895-ym0jsir5	20	9	also	also	RB
cord-254895-ym0jsir5	20	10	been	be	VBN
cord-254895-ym0jsir5	20	11	described	describe	VBN
cord-254895-ym0jsir5	20	12	as	as	IN
cord-254895-ym0jsir5	20	13	natural	natural	JJ
cord-254895-ym0jsir5	20	14	interferon	interferon	NN
cord-254895-ym0jsir5	20	15	producing	produce	VBG
cord-254895-ym0jsir5	20	16	cells	cell	NNS
cord-254895-ym0jsir5	20	17	(	(	-LRB-
cord-254895-ym0jsir5	20	18	Perussia	Perussia	NNP
cord-254895-ym0jsir5	20	19	et	et	NNP
cord-254895-ym0jsir5	20	20	al	al	NNP
cord-254895-ym0jsir5	20	21	.	.	NNP
cord-254895-ym0jsir5	20	22	,	,	,
cord-254895-ym0jsir5	20	23	1985	1985	CD
cord-254895-ym0jsir5	20	24	;	;	:
cord-254895-ym0jsir5	20	25	Ronnblom	Ronnblom	NNP
cord-254895-ym0jsir5	20	26	et	et	FW
cord-254895-ym0jsir5	20	27	al	al	NNP
cord-254895-ym0jsir5	20	28	.	.	NNP
cord-254895-ym0jsir5	20	29	,	,	,
cord-254895-ym0jsir5	20	30	1983	1983	CD
cord-254895-ym0jsir5	20	31	)	)	-RRB-
cord-254895-ym0jsir5	20	32	represent	represent	VBP
cord-254895-ym0jsir5	20	33	a	a	DT
cord-254895-ym0jsir5	20	34	specialized	specialized	JJ
cord-254895-ym0jsir5	20	35	subset	subset	NN
cord-254895-ym0jsir5	20	36	of	of	IN
cord-254895-ym0jsir5	20	37	DCs	dc	NNS
cord-254895-ym0jsir5	20	38	characterized	characterize	VBN
cord-254895-ym0jsir5	20	39	by	by	IN
cord-254895-ym0jsir5	20	40	their	-PRON-	PRP$
cord-254895-ym0jsir5	20	41	ability	ability	NN
cord-254895-ym0jsir5	20	42	to	to	TO
cord-254895-ym0jsir5	20	43	express	express	VB
cord-254895-ym0jsir5	20	44	large	large	JJ
cord-254895-ym0jsir5	20	45	amounts	amount	NNS
cord-254895-ym0jsir5	20	46	of	of	IN
cord-254895-ym0jsir5	20	47	type	type	NN
cord-254895-ym0jsir5	21	1	I	-PRON-	PRP
cord-254895-ym0jsir5	21	2	interferons	interferon	NNS
cord-254895-ym0jsir5	21	3	and	and	CC
cord-254895-ym0jsir5	21	4	interferoninduced	interferoninduced	JJ
cord-254895-ym0jsir5	21	5	genes	gene	NNS
cord-254895-ym0jsir5	21	6	in	in	IN
cord-254895-ym0jsir5	21	7	response	response	NN
cord-254895-ym0jsir5	21	8	to	to	IN
cord-254895-ym0jsir5	21	9	viruses	virus	NNS
cord-254895-ym0jsir5	21	10	as	as	RB
cord-254895-ym0jsir5	21	11	well	well	RB
cord-254895-ym0jsir5	21	12	as	as	IN
cord-254895-ym0jsir5	21	13	synthetic	synthetic	JJ
cord-254895-ym0jsir5	21	14	TLR7	TLR7	NNP
cord-254895-ym0jsir5	21	15	and	and	CC
cord-254895-ym0jsir5	21	16	TLR9	tlr9	CD
cord-254895-ym0jsir5	21	17	ligands	ligand	NNS
cord-254895-ym0jsir5	22	1	(	(	-LRB-
cord-254895-ym0jsir5	22	2	Cella	Cella	NNP
cord-254895-ym0jsir5	22	3	et	et	FW
cord-254895-ym0jsir5	22	4	al	al	NNP
cord-254895-ym0jsir5	22	5	.	.	.
cord-254895-ym0jsir5	23	1	,	,	,
cord-254895-ym0jsir5	23	2	1999	1999	CD
cord-254895-ym0jsir5	23	3	;	;	:
cord-254895-ym0jsir5	23	4	Krug	Krug	NNP
cord-254895-ym0jsir5	23	5	et	et	NNP
cord-254895-ym0jsir5	23	6	al	al	NNP
cord-254895-ym0jsir5	23	7	.	.	.
cord-254895-ym0jsir5	24	1	,	,	,
cord-254895-ym0jsir5	24	2	2004a	2004a	CD
cord-254895-ym0jsir5	24	3	Krug	Krug	NNP
cord-254895-ym0jsir5	24	4	et	et	NNP
cord-254895-ym0jsir5	24	5	al	al	NNP
cord-254895-ym0jsir5	24	6	.	.	.
cord-254895-ym0jsir5	25	1	,	,	,
cord-254895-ym0jsir5	25	2	,	,	,
cord-254895-ym0jsir5	25	3	2001	2001	CD
cord-254895-ym0jsir5	25	4	Siegal	Siegal	NNP
cord-254895-ym0jsir5	25	5	et	et	NNP
cord-254895-ym0jsir5	25	6	al	al	NNP
cord-254895-ym0jsir5	25	7	.	.	NNP
cord-254895-ym0jsir5	25	8	,	,	,
cord-254895-ym0jsir5	25	9	1999	1999	CD
cord-254895-ym0jsir5	25	10	)	)	-RRB-
cord-254895-ym0jsir5	25	11	.	.	.
cord-254895-ym0jsir5	26	1	In	in	IN
cord-254895-ym0jsir5	26	2	response	response	NN
cord-254895-ym0jsir5	26	3	to	to	IN
cord-254895-ym0jsir5	26	4	many	many	JJ
cord-254895-ym0jsir5	26	5	viruses	virus	NNS
cord-254895-ym0jsir5	26	6	pDCs	pdc	VBN
cord-254895-ym0jsir5	26	7	produce	produce	VBP
cord-254895-ym0jsir5	26	8	10-to	10-to	CD
cord-254895-ym0jsir5	26	9	100fold	100fold	JJ
cord-254895-ym0jsir5	26	10	more	more	JJR
cord-254895-ym0jsir5	26	11	type	type	NN
cord-254895-ym0jsir5	27	1	I	-PRON-	PRP
cord-254895-ym0jsir5	27	2	interferon	interferon	VBD
cord-254895-ym0jsir5	27	3	on	on	IN
cord-254895-ym0jsir5	27	4	a	a	DT
cord-254895-ym0jsir5	27	5	single	single	JJ
cord-254895-ym0jsir5	27	6	cell	cell	NN
cord-254895-ym0jsir5	27	7	basis	basis	NN
cord-254895-ym0jsir5	27	8	than	than	IN
cord-254895-ym0jsir5	27	9	other	other	JJ
cord-254895-ym0jsir5	27	10	cell	cell	NN
cord-254895-ym0jsir5	27	11	types	type	NNS
cord-254895-ym0jsir5	27	12	such	such	JJ
cord-254895-ym0jsir5	27	13	as	as	IN
cord-254895-ym0jsir5	27	14	conventional	conventional	JJ
cord-254895-ym0jsir5	27	15	DC	DC	NNP
cord-254895-ym0jsir5	27	16	or	or	CC
cord-254895-ym0jsir5	27	17	macrophages	macrophage	NNS
cord-254895-ym0jsir5	27	18	(	(	-LRB-
cord-254895-ym0jsir5	27	19	Colonna	Colonna	NNP
cord-254895-ym0jsir5	27	20	et	et	FW
cord-254895-ym0jsir5	27	21	al	al	NNP
cord-254895-ym0jsir5	27	22	.	.	NNP
cord-254895-ym0jsir5	27	23	,	,	,
cord-254895-ym0jsir5	27	24	2002	2002	CD
cord-254895-ym0jsir5	27	25	)	)	-RRB-
cord-254895-ym0jsir5	27	26	.	.	.
cord-254895-ym0jsir5	28	1	In	in	IN
cord-254895-ym0jsir5	28	2	many	many	JJ
cord-254895-ym0jsir5	28	3	viral	viral	JJ
cord-254895-ym0jsir5	28	4	infections	infection	NNS
cord-254895-ym0jsir5	28	5	pDCs	pdc	VBN
cord-254895-ym0jsir5	28	6	have	have	VBP
cord-254895-ym0jsir5	28	7	been	be	VBN
cord-254895-ym0jsir5	28	8	shown	show	VBN
cord-254895-ym0jsir5	28	9	to	to	TO
cord-254895-ym0jsir5	28	10	release	release	VB
cord-254895-ym0jsir5	28	11	the	the	DT
cord-254895-ym0jsir5	28	12	first	first	JJ
cord-254895-ym0jsir5	28	13	wave	wave	NN
cord-254895-ym0jsir5	28	14	of	of	IN
cord-254895-ym0jsir5	28	15	type	type	NN
cord-254895-ym0jsir5	28	16	I	-PRON-	PRP
cord-254895-ym0jsir5	28	17	interferons	interferon	NNS
cord-254895-ym0jsir5	28	18	and	and	CC
cord-254895-ym0jsir5	28	19	thus	thus	RB
cord-254895-ym0jsir5	28	20	support	support	VBP
cord-254895-ym0jsir5	28	21	subsequent	subsequent	JJ
cord-254895-ym0jsir5	28	22	steps	step	NNS
cord-254895-ym0jsir5	28	23	of	of	IN
cord-254895-ym0jsir5	28	24	antiviral	antiviral	JJ
cord-254895-ym0jsir5	28	25	immunity	immunity	NN
cord-254895-ym0jsir5	28	26	,	,	,
cord-254895-ym0jsir5	28	27	including	include	VBG
cord-254895-ym0jsir5	28	28	NK	NK	NNP
cord-254895-ym0jsir5	28	29	cell	cell	NN
cord-254895-ym0jsir5	28	30	activation	activation	NN
cord-254895-ym0jsir5	28	31	,	,	,
cord-254895-ym0jsir5	28	32	Th1	th1	NN
cord-254895-ym0jsir5	28	33	cell	cell	NN
cord-254895-ym0jsir5	28	34	and	and	CC
cord-254895-ym0jsir5	28	35	CTL	CTL	NNP
cord-254895-ym0jsir5	28	36	differentiation	differentiation	NN
cord-254895-ym0jsir5	29	1	(	(	-LRB-
cord-254895-ym0jsir5	29	2	Dalod	Dalod	NNP
cord-254895-ym0jsir5	29	3	et	et	FW
cord-254895-ym0jsir5	29	4	al	al	NNP
cord-254895-ym0jsir5	29	5	.	.	NNP
cord-254895-ym0jsir5	29	6	,	,	,
cord-254895-ym0jsir5	29	7	2002	2002	CD
cord-254895-ym0jsir5	30	1	(	(	-LRB-
cord-254895-ym0jsir5	30	2	Dalod	Dalod	NNP
cord-254895-ym0jsir5	30	3	et	et	FW
cord-254895-ym0jsir5	30	4	al	al	NNP
cord-254895-ym0jsir5	30	5	.	.	.
cord-254895-ym0jsir5	31	1	,	,	,
cord-254895-ym0jsir5	31	2	,	,	,
cord-254895-ym0jsir5	31	3	2003	2003	CD
cord-254895-ym0jsir5	31	4	Krug	Krug	NNP
cord-254895-ym0jsir5	31	5	et	et	NNP
cord-254895-ym0jsir5	31	6	al	al	NNP
cord-254895-ym0jsir5	31	7	.	.	NNP
cord-254895-ym0jsir5	31	8	,	,	,
cord-254895-ym0jsir5	31	9	2004a	2004a	CD
cord-254895-ym0jsir5	31	10	;	;	:
cord-254895-ym0jsir5	31	11	Cervantes	Cervantes	NNP
cord-254895-ym0jsir5	31	12	-	-	HYPH
cord-254895-ym0jsir5	31	13	Barragan	Barragan	NNP
cord-254895-ym0jsir5	31	14	et	et	NNP
cord-254895-ym0jsir5	31	15	al	al	NNP
cord-254895-ym0jsir5	31	16	.	.	NNP
cord-254895-ym0jsir5	31	17	,	,	,
cord-254895-ym0jsir5	31	18	2006	2006	CD
cord-254895-ym0jsir5	31	19	)	)	-RRB-
cord-254895-ym0jsir5	31	20	.	.	.
cord-254895-ym0jsir5	32	1	It	-PRON-	PRP
cord-254895-ym0jsir5	32	2	has	have	VBZ
cord-254895-ym0jsir5	32	3	been	be	VBN
cord-254895-ym0jsir5	32	4	shown	show	VBN
cord-254895-ym0jsir5	32	5	in	in	IN
cord-254895-ym0jsir5	32	6	vivo	vivo	NN
cord-254895-ym0jsir5	32	7	and	and	CC
cord-254895-ym0jsir5	32	8	in	in	IN
cord-254895-ym0jsir5	32	9	vitro	vitro	FW
cord-254895-ym0jsir5	32	10	however	however	RB
cord-254895-ym0jsir5	32	11	,	,	,
cord-254895-ym0jsir5	32	12	that	that	IN
cord-254895-ym0jsir5	32	13	cells	cell	NNS
cord-254895-ym0jsir5	32	14	other	other	JJ
cord-254895-ym0jsir5	32	15	than	than	IN
cord-254895-ym0jsir5	32	16	pDCs	pDCs	NNP
cord-254895-ym0jsir5	33	1	(	(	-LRB-
cord-254895-ym0jsir5	33	2	for	for	IN
cord-254895-ym0jsir5	33	3	example	example	NN
cord-254895-ym0jsir5	33	4	conventional	conventional	JJ
cord-254895-ym0jsir5	33	5	DCs	dc	NNS
cord-254895-ym0jsir5	33	6	,	,	,
cord-254895-ym0jsir5	33	7	macrophages	macrophage	NNS
cord-254895-ym0jsir5	33	8	and	and	CC
cord-254895-ym0jsir5	33	9	non	non	JJ
cord-254895-ym0jsir5	33	10	-	-	JJ
cord-254895-ym0jsir5	33	11	immune	immune	JJ
cord-254895-ym0jsir5	33	12	cells	cell	NNS
cord-254895-ym0jsir5	33	13	)	)	-RRB-
cord-254895-ym0jsir5	33	14	,	,	,
cord-254895-ym0jsir5	33	15	also	also	RB
cord-254895-ym0jsir5	33	16	significantly	significantly	RB
cord-254895-ym0jsir5	33	17	contribute	contribute	VBP
cord-254895-ym0jsir5	33	18	to	to	IN
cord-254895-ym0jsir5	33	19	type	type	NN
cord-254895-ym0jsir5	33	20	I	-PRON-	PRP
cord-254895-ym0jsir5	33	21	IFN	IFN	NNP
cord-254895-ym0jsir5	33	22	responses	response	NNS
cord-254895-ym0jsir5	33	23	during	during	IN
cord-254895-ym0jsir5	33	24	viral	viral	JJ
cord-254895-ym0jsir5	33	25	infection	infection	NN
cord-254895-ym0jsir5	33	26	despite	despite	IN
cord-254895-ym0jsir5	33	27	the	the	DT
cord-254895-ym0jsir5	33	28	lower	low	JJR
cord-254895-ym0jsir5	33	29	amount	amount	NN
cord-254895-ym0jsir5	33	30	of	of	IN
cord-254895-ym0jsir5	33	31	type	type	NN
cord-254895-ym0jsir5	34	1	I	-PRON-	PRP
cord-254895-ym0jsir5	34	2	interferon	interferon	RB
cord-254895-ym0jsir5	34	3	produced	produce	VBD
cord-254895-ym0jsir5	34	4	per	per	IN
cord-254895-ym0jsir5	34	5	cell	cell	NN
cord-254895-ym0jsir5	34	6	Barchet	Barchet	NNP
cord-254895-ym0jsir5	34	7	et	et	NNP
cord-254895-ym0jsir5	34	8	al	al	NNP
cord-254895-ym0jsir5	34	9	.	.	NNP
cord-254895-ym0jsir5	34	10	2005	2005	CD
cord-254895-ym0jsir5	34	11	;	;	:
cord-254895-ym0jsir5	34	12	Krug	Krug	NNP
cord-254895-ym0jsir5	34	13	et	et	NNP
cord-254895-ym0jsir5	34	14	al	al	NNP
cord-254895-ym0jsir5	34	15	.	.	NNP
cord-254895-ym0jsir5	34	16	,	,	,
cord-254895-ym0jsir5	34	17	2004a	2004a	CD
cord-254895-ym0jsir5	34	18	)	)	-RRB-
cord-254895-ym0jsir5	34	19	.	.	.
cord-254895-ym0jsir5	35	1	In	in	IN
cord-254895-ym0jsir5	35	2	contrast	contrast	NN
cord-254895-ym0jsir5	35	3	to	to	IN
cord-254895-ym0jsir5	35	4	other	other	JJ
cord-254895-ym0jsir5	35	5	DC	DC	NNP
cord-254895-ym0jsir5	35	6	populations	population	NNS
cord-254895-ym0jsir5	35	7	,	,	,
cord-254895-ym0jsir5	35	8	pDCs	pdcs	PRP
cord-254895-ym0jsir5	35	9	are	be	VBP
cord-254895-ym0jsir5	35	10	less	less	RBR
cord-254895-ym0jsir5	35	11	efficient	efficient	JJ
cord-254895-ym0jsir5	35	12	in	in	IN
cord-254895-ym0jsir5	35	13	presenting	present	VBG
cord-254895-ym0jsir5	35	14	antigens	antigen	NNS
cord-254895-ym0jsir5	35	15	.	.	.
cord-254895-ym0jsir5	36	1	Several	several	JJ
cord-254895-ym0jsir5	36	2	studies	study	NNS
cord-254895-ym0jsir5	36	3	report	report	VBP
cord-254895-ym0jsir5	36	4	that	that	IN
cord-254895-ym0jsir5	36	5	pDCs	pdcs	PRP
cord-254895-ym0jsir5	36	6	are	be	VBP
cord-254895-ym0jsir5	36	7	capable	capable	JJ
cord-254895-ym0jsir5	36	8	of	of	IN
cord-254895-ym0jsir5	36	9	presenting	present	VBG
cord-254895-ym0jsir5	36	10	antigens	antigen	NNS
cord-254895-ym0jsir5	36	11	to	to	IN
cord-254895-ym0jsir5	36	12	T	t	NN
cord-254895-ym0jsir5	36	13	cells	cell	NNS
cord-254895-ym0jsir5	36	14	and	and	CC
cord-254895-ym0jsir5	36	15	triggering	trigger	VBG
cord-254895-ym0jsir5	36	16	T	t	NN
cord-254895-ym0jsir5	36	17	cell	cell	NN
cord-254895-ym0jsir5	36	18	proliferation	proliferation	NN
cord-254895-ym0jsir5	36	19	and	and	CC
cord-254895-ym0jsir5	36	20	differentiation	differentiation	NN
cord-254895-ym0jsir5	36	21	to	to	TO
cord-254895-ym0jsir5	36	22	effector	effector	VB
cord-254895-ym0jsir5	36	23	cells	cell	NNS
cord-254895-ym0jsir5	36	24	(	(	-LRB-
cord-254895-ym0jsir5	37	1	Boonstra	Boonstra	NNP
cord-254895-ym0jsir5	37	2	et	et	NNP
cord-254895-ym0jsir5	37	3	al	al	NNP
cord-254895-ym0jsir5	37	4	.	.	.
cord-254895-ym0jsir5	38	1	,	,	,
cord-254895-ym0jsir5	38	2	2003	2003	CD
cord-254895-ym0jsir5	38	3	;	;	:
cord-254895-ym0jsir5	38	4	Dalod	Dalod	NNP
cord-254895-ym0jsir5	38	5	et	et	FW
cord-254895-ym0jsir5	38	6	al	al	NNP
cord-254895-ym0jsir5	38	7	.	.	NNP
cord-254895-ym0jsir5	38	8	,	,	,
cord-254895-ym0jsir5	38	9	2003	2003	CD
cord-254895-ym0jsir5	39	1	;	;	:
cord-254895-ym0jsir5	39	2	Salio	Salio	NNP
cord-254895-ym0jsir5	39	3	et	et	NNP
cord-254895-ym0jsir5	39	4	al	al	NNP
cord-254895-ym0jsir5	39	5	.	.	NNP
cord-254895-ym0jsir5	39	6	,	,	,
cord-254895-ym0jsir5	39	7	2004	2004	CD
cord-254895-ym0jsir5	39	8	;	;	:
cord-254895-ym0jsir5	39	9	Schlecht	Schlecht	NNP
cord-254895-ym0jsir5	39	10	et	et	FW
cord-254895-ym0jsir5	39	11	al	al	NNP
cord-254895-ym0jsir5	39	12	.	.	NNP
cord-254895-ym0jsir5	39	13	,	,	,
cord-254895-ym0jsir5	39	14	2004	2004	CD
cord-254895-ym0jsir5	39	15	)	)	-RRB-
cord-254895-ym0jsir5	39	16	.	.	.
cord-254895-ym0jsir5	40	1	However	however	RB
cord-254895-ym0jsir5	40	2	,	,	,
cord-254895-ym0jsir5	40	3	initial	initial	JJ
cord-254895-ym0jsir5	40	4	priming	priming	NN
cord-254895-ym0jsir5	40	5	of	of	IN
cord-254895-ym0jsir5	40	6	T	T	NNP
cord-254895-ym0jsir5	40	7	cell	cell	NN
cord-254895-ym0jsir5	40	8	responses	response	NNS
cord-254895-ym0jsir5	40	9	in	in	IN
cord-254895-ym0jsir5	40	10	many	many	JJ
cord-254895-ym0jsir5	40	11	viral	viral	JJ
cord-254895-ym0jsir5	40	12	infections	infection	NNS
cord-254895-ym0jsir5	40	13	relies	rely	VBZ
cord-254895-ym0jsir5	40	14	on	on	IN
cord-254895-ym0jsir5	40	15	conventional	conventional	JJ
cord-254895-ym0jsir5	40	16	DCs	dc	NNS
cord-254895-ym0jsir5	40	17	,	,	,
cord-254895-ym0jsir5	40	18	especially	especially	RB
cord-254895-ym0jsir5	40	19	the	the	DT
cord-254895-ym0jsir5	40	20	CD8a	CD8a	NNP
cord-254895-ym0jsir5	40	21	+	+	CC
cord-254895-ym0jsir5	40	22	DCs	dc	NNS
cord-254895-ym0jsir5	40	23	in	in	IN
cord-254895-ym0jsir5	40	24	the	the	DT
cord-254895-ym0jsir5	40	25	murine	murine	JJ
cord-254895-ym0jsir5	40	26	system	system	NN
cord-254895-ym0jsir5	40	27	(	(	-LRB-
cord-254895-ym0jsir5	40	28	Belz	Belz	NNP
cord-254895-ym0jsir5	40	29	et	et	NNP
cord-254895-ym0jsir5	40	30	al	al	NNP
cord-254895-ym0jsir5	40	31	.	.	NNP
cord-254895-ym0jsir5	40	32	,	,	,
cord-254895-ym0jsir5	40	33	2004	2004	CD
cord-254895-ym0jsir5	40	34	)	)	-RRB-
cord-254895-ym0jsir5	40	35	.	.	.
cord-254895-ym0jsir5	41	1	In	in	IN
cord-254895-ym0jsir5	41	2	addition	addition	NN
cord-254895-ym0jsir5	41	3	it	-PRON-	PRP
cord-254895-ym0jsir5	41	4	has	have	VBZ
cord-254895-ym0jsir5	41	5	been	be	VBN
cord-254895-ym0jsir5	41	6	reported	report	VBN
cord-254895-ym0jsir5	41	7	recently	recently	RB
cord-254895-ym0jsir5	41	8	that	that	DT
cord-254895-ym0jsir5	41	9	pDCs	pdcs	XX
cord-254895-ym0jsir5	42	1	activated	activate	VBN
cord-254895-ym0jsir5	42	2	via	via	IN
cord-254895-ym0jsir5	42	3	TLRs	tlr	NNS
cord-254895-ym0jsir5	42	4	may	may	MD
cord-254895-ym0jsir5	42	5	also	also	RB
cord-254895-ym0jsir5	42	6	induce	induce	VB
cord-254895-ym0jsir5	42	7	regulatory	regulatory	JJ
cord-254895-ym0jsir5	42	8	T	t	NN
cord-254895-ym0jsir5	42	9	cells	cell	NNS
cord-254895-ym0jsir5	42	10	(	(	-LRB-
cord-254895-ym0jsir5	42	11	Moseman	Moseman	NNP
cord-254895-ym0jsir5	42	12	et	et	NNP
cord-254895-ym0jsir5	42	13	al	al	NNP
cord-254895-ym0jsir5	42	14	.	.	NNP
cord-254895-ym0jsir5	42	15	,	,	,
cord-254895-ym0jsir5	42	16	2004	2004	CD
cord-254895-ym0jsir5	42	17	)	)	-RRB-
cord-254895-ym0jsir5	42	18	,	,	,
cord-254895-ym0jsir5	42	19	which	which	WDT
cord-254895-ym0jsir5	42	20	may	may	MD
cord-254895-ym0jsir5	42	21	inhibit	inhibit	VB
cord-254895-ym0jsir5	42	22	the	the	DT
cord-254895-ym0jsir5	42	23	expansion	expansion	NN
cord-254895-ym0jsir5	42	24	and	and	CC
cord-254895-ym0jsir5	42	25	differentiation	differentiation	NN
cord-254895-ym0jsir5	42	26	of	of	IN
cord-254895-ym0jsir5	42	27	antiviral	antiviral	JJ
cord-254895-ym0jsir5	42	28	T	t	NN
cord-254895-ym0jsir5	42	29	lymphocytes	lymphocyte	NNS
cord-254895-ym0jsir5	42	30	to	to	TO
cord-254895-ym0jsir5	42	31	prevent	prevent	VB
cord-254895-ym0jsir5	42	32	overstimulation	overstimulation	NN
cord-254895-ym0jsir5	42	33	of	of	IN
cord-254895-ym0jsir5	42	34	the	the	DT
cord-254895-ym0jsir5	42	35	immune	immune	JJ
cord-254895-ym0jsir5	42	36	system	system	NN
cord-254895-ym0jsir5	42	37	.	.	.
cord-254895-ym0jsir5	43	1	What	what	WP
cord-254895-ym0jsir5	43	2	is	be	VBZ
cord-254895-ym0jsir5	43	3	the	the	DT
cord-254895-ym0jsir5	43	4	molecular	molecular	JJ
cord-254895-ym0jsir5	43	5	basis	basis	NN
cord-254895-ym0jsir5	43	6	for	for	IN
cord-254895-ym0jsir5	43	7	the	the	DT
cord-254895-ym0jsir5	43	8	rapid	rapid	JJ
cord-254895-ym0jsir5	43	9	and	and	CC
cord-254895-ym0jsir5	43	10	robust	robust	JJ
cord-254895-ym0jsir5	43	11	interferon	interferon	NN
cord-254895-ym0jsir5	43	12	production	production	NN
cord-254895-ym0jsir5	43	13	in	in	IN
cord-254895-ym0jsir5	43	14	pDCs	pDCs	NNP
cord-254895-ym0jsir5	43	15	?	?	.
cord-254895-ym0jsir5	44	1	pDCs	pDCs	NNP
cord-254895-ym0jsir5	44	2	recognize	recognize	VB
cord-254895-ym0jsir5	44	3	viruses	virus	NNS
cord-254895-ym0jsir5	44	4	via	via	IN
cord-254895-ym0jsir5	44	5	TLRs	tlr	NNS
cord-254895-ym0jsir5	44	6	,	,	,
cord-254895-ym0jsir5	44	7	particularly	particularly	RB
cord-254895-ym0jsir5	44	8	via	via	IN
cord-254895-ym0jsir5	44	9	the	the	DT
cord-254895-ym0jsir5	44	10	endosomally	endosomally	RB
cord-254895-ym0jsir5	44	11	located	locate	VBN
cord-254895-ym0jsir5	44	12	TLR7	TLR7	NNP
cord-254895-ym0jsir5	44	13	,	,	,
cord-254895-ym0jsir5	44	14	TLR8	TLR8	NNP
cord-254895-ym0jsir5	44	15	and	and	CC
cord-254895-ym0jsir5	44	16	TLR9	TLR9	NNP
cord-254895-ym0jsir5	44	17	.	.	.
cord-254895-ym0jsir5	45	1	Downstream	downstream	JJ
cord-254895-ym0jsir5	45	2	signaling	signaling	NN
cord-254895-ym0jsir5	45	3	of	of	IN
cord-254895-ym0jsir5	45	4	TLR7/8	tlr7/8	NN
cord-254895-ym0jsir5	46	1	and	and	CC
cord-254895-ym0jsir5	46	2	TLR9	TLR9	NNP
cord-254895-ym0jsir5	46	3	leads	lead	VBZ
cord-254895-ym0jsir5	46	4	to	to	IN
cord-254895-ym0jsir5	46	5	the	the	DT
cord-254895-ym0jsir5	46	6	activation	activation	NN
cord-254895-ym0jsir5	46	7	of	of	IN
cord-254895-ym0jsir5	46	8	IRF7	IRF7	NNP
cord-254895-ym0jsir5	46	9	,	,	,
cord-254895-ym0jsir5	46	10	which	which	WDT
cord-254895-ym0jsir5	46	11	is	be	VBZ
cord-254895-ym0jsir5	46	12	the	the	DT
cord-254895-ym0jsir5	46	13	central	central	JJ
cord-254895-ym0jsir5	46	14	transcription	transcription	NN
cord-254895-ym0jsir5	46	15	factor	factor	NN
cord-254895-ym0jsir5	46	16	for	for	IN
cord-254895-ym0jsir5	46	17	expression	expression	NN
cord-254895-ym0jsir5	46	18	of	of	IN
cord-254895-ym0jsir5	46	19	type	type	NN
cord-254895-ym0jsir5	47	1	I	-PRON-	PRP
cord-254895-ym0jsir5	47	2	interferon	interferon	VBD
cord-254895-ym0jsir5	47	3	and	and	CC
cord-254895-ym0jsir5	47	4	interferon	interferon	NN
cord-254895-ym0jsir5	47	5	inducible	inducible	JJ
cord-254895-ym0jsir5	47	6	genes	gene	NNS
cord-254895-ym0jsir5	47	7	(	(	-LRB-
cord-254895-ym0jsir5	47	8	Honda	Honda	NNP
cord-254895-ym0jsir5	47	9	et	et	NNP
cord-254895-ym0jsir5	47	10	al	al	NNP
cord-254895-ym0jsir5	47	11	.	.	NNP
cord-254895-ym0jsir5	47	12	,	,	,
cord-254895-ym0jsir5	47	13	2005b	2005b	CD
cord-254895-ym0jsir5	47	14	)	)	-RRB-
cord-254895-ym0jsir5	47	15	.	.	.
cord-254895-ym0jsir5	48	1	In	in	IN
cord-254895-ym0jsir5	48	2	contrast	contrast	NN
cord-254895-ym0jsir5	48	3	to	to	IN
cord-254895-ym0jsir5	48	4	most	most	JJS
cord-254895-ym0jsir5	48	5	other	other	JJ
cord-254895-ym0jsir5	48	6	cell	cell	NN
cord-254895-ym0jsir5	48	7	types	type	NNS
cord-254895-ym0jsir5	49	1	pDCs	pDCs	NNP
cord-254895-ym0jsir5	49	2	show	show	VBP
cord-254895-ym0jsir5	49	3	constitutive	constitutive	JJ
cord-254895-ym0jsir5	49	4	expression	expression	NN
cord-254895-ym0jsir5	49	5	of	of	IN
cord-254895-ym0jsir5	49	6	IRF7	IRF7	NNP
cord-254895-ym0jsir5	49	7	which	which	WDT
cord-254895-ym0jsir5	49	8	is	be	VBZ
cord-254895-ym0jsir5	49	9	required	require	VBN
cord-254895-ym0jsir5	49	10	for	for	IN
cord-254895-ym0jsir5	49	11	the	the	DT
cord-254895-ym0jsir5	49	12	rapid	rapid	JJ
cord-254895-ym0jsir5	49	13	and	and	CC
cord-254895-ym0jsir5	49	14	potent	potent	JJ
cord-254895-ym0jsir5	49	15	production	production	NN
cord-254895-ym0jsir5	49	16	of	of	IN
cord-254895-ym0jsir5	49	17	the	the	DT
cord-254895-ym0jsir5	49	18	full	full	JJ
cord-254895-ym0jsir5	49	19	range	range	NN
cord-254895-ym0jsir5	49	20	of	of	IN
cord-254895-ym0jsir5	49	21	type	type	NN
cord-254895-ym0jsir5	49	22	I	-PRON-	PRP
cord-254895-ym0jsir5	49	23	IFNs	ifns	VBP
cord-254895-ym0jsir5	50	1	(	(	-LRB-
cord-254895-ym0jsir5	50	2	Izaguirre	Izaguirre	NNP
cord-254895-ym0jsir5	50	3	et	et	NNP
cord-254895-ym0jsir5	50	4	al	al	NNP
cord-254895-ym0jsir5	50	5	.	.	.
cord-254895-ym0jsir5	51	1	,	,	,
cord-254895-ym0jsir5	51	2	2003	2003	CD
cord-254895-ym0jsir5	51	3	;	;	:
cord-254895-ym0jsir5	51	4	Kerkmann	Kerkmann	NNP
cord-254895-ym0jsir5	51	5	et	et	NNP
cord-254895-ym0jsir5	51	6	al	al	NNP
cord-254895-ym0jsir5	51	7	.	.	NNP
cord-254895-ym0jsir5	51	8	,	,	,
cord-254895-ym0jsir5	51	9	2003	2003	CD
cord-254895-ym0jsir5	51	10	)	)	-RRB-
cord-254895-ym0jsir5	51	11	.	.	.
cord-254895-ym0jsir5	52	1	pDC	pDC	NNP
cord-254895-ym0jsir5	52	2	are	be	VBP
cord-254895-ym0jsir5	52	3	unique	unique	JJ
cord-254895-ym0jsir5	52	4	in	in	IN
cord-254895-ym0jsir5	52	5	that	that	IN
cord-254895-ym0jsir5	52	6	IFN	IFN	NNP
cord-254895-ym0jsir5	52	7	-	-	:
cord-254895-ym0jsir5	52	8	a	a	DT
cord-254895-ym0jsir5	52	9	expression	expression	NN
cord-254895-ym0jsir5	52	10	is	be	VBZ
cord-254895-ym0jsir5	52	11	induced	induce	VBN
cord-254895-ym0jsir5	52	12	by	by	IN
cord-254895-ym0jsir5	52	13	ligands	ligand	NNS
cord-254895-ym0jsir5	52	14	of	of	IN
cord-254895-ym0jsir5	52	15	TLR7/8	TLR7/8	NNP
cord-254895-ym0jsir5	53	1	and	and	CC
cord-254895-ym0jsir5	53	2	TLR9	TLR9	NNP
cord-254895-ym0jsir5	53	3	via	via	IN
cord-254895-ym0jsir5	53	4	a	a	DT
cord-254895-ym0jsir5	53	5	supramolecular	supramolecular	JJ
cord-254895-ym0jsir5	53	6	complex	complex	NN
cord-254895-ym0jsir5	53	7	formed	form	VBN
cord-254895-ym0jsir5	53	8	between	between	IN
cord-254895-ym0jsir5	53	9	MyD88	MyD88	NNP
cord-254895-ym0jsir5	53	10	,	,	,
cord-254895-ym0jsir5	53	11	TRAF6	traf6	NN
cord-254895-ym0jsir5	53	12	,	,	,
cord-254895-ym0jsir5	53	13	IRAK1/4	IRAK1/4	NNP
cord-254895-ym0jsir5	53	14	and	and	CC
cord-254895-ym0jsir5	53	15	IRF7	IRF7	NNP
cord-254895-ym0jsir5	53	16	,	,	,
cord-254895-ym0jsir5	53	17	which	which	WDT
cord-254895-ym0jsir5	53	18	leads	lead	VBZ
cord-254895-ym0jsir5	53	19	to	to	IN
cord-254895-ym0jsir5	53	20	direct	direct	JJ
cord-254895-ym0jsir5	53	21	activation	activation	NN
cord-254895-ym0jsir5	53	22	of	of	IN
cord-254895-ym0jsir5	53	23	the	the	DT
cord-254895-ym0jsir5	53	24	constitutively	constitutively	RB
cord-254895-ym0jsir5	53	25	expressed	express	VBN
cord-254895-ym0jsir5	53	26	IRF7	IRF7	NNP
cord-254895-ym0jsir5	53	27	only	only	RB
cord-254895-ym0jsir5	53	28	in	in	IN
cord-254895-ym0jsir5	53	29	this	this	DT
cord-254895-ym0jsir5	53	30	specialized	specialized	JJ
cord-254895-ym0jsir5	53	31	cell	cell	NN
cord-254895-ym0jsir5	53	32	type	type	NN
cord-254895-ym0jsir5	53	33	(	(	-LRB-
cord-254895-ym0jsir5	53	34	Honda	Honda	NNP
cord-254895-ym0jsir5	53	35	et	et	NNP
cord-254895-ym0jsir5	53	36	al	al	NNP
cord-254895-ym0jsir5	53	37	.	.	NNP
cord-254895-ym0jsir5	53	38	,	,	,
cord-254895-ym0jsir5	53	39	2004	2004	CD
cord-254895-ym0jsir5	53	40	;	;	:
cord-254895-ym0jsir5	53	41	Kawai	Kawai	NNP
cord-254895-ym0jsir5	53	42	et	et	NNP
cord-254895-ym0jsir5	53	43	al	al	NNP
cord-254895-ym0jsir5	53	44	.	.	NNP
cord-254895-ym0jsir5	53	45	,	,	,
cord-254895-ym0jsir5	53	46	2004	2004	CD
cord-254895-ym0jsir5	53	47	)	)	-RRB-
cord-254895-ym0jsir5	53	48	.	.	.
cord-254895-ym0jsir5	54	1	The	the	DT
cord-254895-ym0jsir5	54	2	cytoplasmatic	cytoplasmatic	JJ
cord-254895-ym0jsir5	54	3	RNA	RNA	NNP
cord-254895-ym0jsir5	54	4	helicases	helicase	NNS
cord-254895-ym0jsir5	54	5	RIG	rig	NN
cord-254895-ym0jsir5	54	6	-	-	:
cord-254895-ym0jsir5	54	7	I	I	NNP
cord-254895-ym0jsir5	54	8	or	or	CC
cord-254895-ym0jsir5	54	9	MDA5	MDA5	NNP
cord-254895-ym0jsir5	54	10	do	do	VBP
cord-254895-ym0jsir5	54	11	not	not	RB
cord-254895-ym0jsir5	54	12	contribute	contribute	VB
cord-254895-ym0jsir5	54	13	to	to	IN
cord-254895-ym0jsir5	54	14	viral	viral	JJ
cord-254895-ym0jsir5	54	15	recognition	recognition	NN
cord-254895-ym0jsir5	54	16	in	in	IN
cord-254895-ym0jsir5	54	17	pDCs	pDCs	NNP
cord-254895-ym0jsir5	54	18	,	,	,
cord-254895-ym0jsir5	54	19	because	because	IN
cord-254895-ym0jsir5	54	20	the	the	DT
cord-254895-ym0jsir5	54	21	response	response	NN
cord-254895-ym0jsir5	54	22	of	of	IN
cord-254895-ym0jsir5	54	23	pDCs	pDCs	NNP
cord-254895-ym0jsir5	54	24	from	from	IN
cord-254895-ym0jsir5	54	25	mice	mouse	NNS
cord-254895-ym0jsir5	54	26	deficient	deficient	JJ
cord-254895-ym0jsir5	54	27	in	in	IN
cord-254895-ym0jsir5	54	28	RIG	rig	NN
cord-254895-ym0jsir5	54	29	-	-	:
cord-254895-ym0jsir5	54	30	I	-PRON-	PRP
cord-254895-ym0jsir5	54	31	or	or	CC
cord-254895-ym0jsir5	54	32	the	the	DT
cord-254895-ym0jsir5	54	33	essential	essential	JJ
cord-254895-ym0jsir5	54	34	signaling	signal	VBG
cord-254895-ym0jsir5	54	35	adaptor	adaptor	NN
cord-254895-ym0jsir5	54	36	of	of	IN
cord-254895-ym0jsir5	54	37	RIG	rig	NN
cord-254895-ym0jsir5	54	38	-	-	:
cord-254895-ym0jsir5	54	39	I	I	NNP
cord-254895-ym0jsir5	54	40	and	and	CC
cord-254895-ym0jsir5	54	41	MDA5	MDA5	NNP
cord-254895-ym0jsir5	54	42	to	to	IN
cord-254895-ym0jsir5	54	43	RNA	RNA	NNP
cord-254895-ym0jsir5	54	44	viruses	virus	NNS
cord-254895-ym0jsir5	54	45	is	be	VBZ
cord-254895-ym0jsir5	54	46	comparable	comparable	JJ
cord-254895-ym0jsir5	54	47	to	to	IN
cord-254895-ym0jsir5	54	48	that	that	DT
cord-254895-ym0jsir5	54	49	of	of	IN
cord-254895-ym0jsir5	54	50	wild	wild	JJ
cord-254895-ym0jsir5	54	51	-	-	HYPH
cord-254895-ym0jsir5	54	52	type	type	NN
cord-254895-ym0jsir5	54	53	mice	mouse	NNS
cord-254895-ym0jsir5	54	54	.	.	.
cord-254895-ym0jsir5	55	1	It	-PRON-	PRP
cord-254895-ym0jsir5	55	2	has	have	VBZ
cord-254895-ym0jsir5	55	3	been	be	VBN
cord-254895-ym0jsir5	55	4	demonstrated	demonstrate	VBN
cord-254895-ym0jsir5	55	5	in	in	IN
cord-254895-ym0jsir5	55	6	several	several	JJ
cord-254895-ym0jsir5	55	7	studies	study	NNS
cord-254895-ym0jsir5	55	8	that	that	WDT
cord-254895-ym0jsir5	55	9	pDCs	pdc	MD
cord-254895-ym0jsir5	55	10	recognize	recognize	VB
cord-254895-ym0jsir5	55	11	herpes	herpes	NN
cord-254895-ym0jsir5	55	12	simplex	simplex	NNP
cord-254895-ym0jsir5	55	13	virus	virus	NN
cord-254895-ym0jsir5	55	14	type	type	NN
cord-254895-ym0jsir5	55	15	1	1	CD
cord-254895-ym0jsir5	55	16	and	and	CC
cord-254895-ym0jsir5	55	17	2	2	CD
cord-254895-ym0jsir5	56	1	(	(	-LRB-
cord-254895-ym0jsir5	56	2	HSV-1	hsv-1	NN
cord-254895-ym0jsir5	56	3	and	and	CC
cord-254895-ym0jsir5	57	1	-2	-2	LS
cord-254895-ym0jsir5	57	2	)	)	-RRB-
cord-254895-ym0jsir5	58	1	(	(	-LRB-
cord-254895-ym0jsir5	58	2	Krug	Krug	NNP
cord-254895-ym0jsir5	58	3	et	et	NNP
cord-254895-ym0jsir5	58	4	al	al	NNP
cord-254895-ym0jsir5	58	5	.	.	NNP
cord-254895-ym0jsir5	58	6	,	,	,
cord-254895-ym0jsir5	58	7	2004b	2004b	CD
cord-254895-ym0jsir5	58	8	;	;	:
cord-254895-ym0jsir5	58	9	Lund	Lund	NNP
cord-254895-ym0jsir5	58	10	et	et	NNP
cord-254895-ym0jsir5	58	11	al	al	NNP
cord-254895-ym0jsir5	58	12	.	.	NNP
cord-254895-ym0jsir5	58	13	,	,	,
cord-254895-ym0jsir5	58	14	2003	2003	CD
cord-254895-ym0jsir5	58	15	)	)	-RRB-
cord-254895-ym0jsir5	58	16	,	,	,
cord-254895-ym0jsir5	58	17	murine	murine	JJ
cord-254895-ym0jsir5	58	18	cytomegalovirus	cytomegalovirus	NN
cord-254895-ym0jsir5	58	19	(	(	-LRB-
cord-254895-ym0jsir5	58	20	MCMV	MCMV	NNP
cord-254895-ym0jsir5	58	21	)	)	-RRB-
cord-254895-ym0jsir5	59	1	(	(	-LRB-
cord-254895-ym0jsir5	59	2	Krug	Krug	NNP
cord-254895-ym0jsir5	59	3	et	et	NNP
cord-254895-ym0jsir5	59	4	al	al	NNP
cord-254895-ym0jsir5	59	5	.	.	.
cord-254895-ym0jsir5	60	1	,	,	,
cord-254895-ym0jsir5	60	2	2004a	2004a	CD
cord-254895-ym0jsir5	60	3	)	)	-RRB-
cord-254895-ym0jsir5	60	4	and	and	CC
cord-254895-ym0jsir5	60	5	also	also	RB
cord-254895-ym0jsir5	60	6	recombinant	recombinant	JJ
cord-254895-ym0jsir5	60	7	replication	replication	NN
cord-254895-ym0jsir5	60	8	-	-	HYPH
cord-254895-ym0jsir5	60	9	deficient	deficient	JJ
cord-254895-ym0jsir5	60	10	adenovirus	adenovirus	NN
cord-254895-ym0jsir5	61	1	(	(	-LRB-
cord-254895-ym0jsir5	61	2	Basner	Basner	NNP
cord-254895-ym0jsir5	61	3	-	-	HYPH
cord-254895-ym0jsir5	61	4	Tschakarjan	Tschakarjan	NNP
cord-254895-ym0jsir5	61	5	et	et	NNP
cord-254895-ym0jsir5	61	6	al	al	NNP
cord-254895-ym0jsir5	61	7	.	.	NNP
cord-254895-ym0jsir5	61	8	,	,	,
cord-254895-ym0jsir5	61	9	2006	2006	CD
cord-254895-ym0jsir5	61	10	)	)	-RRB-
cord-254895-ym0jsir5	61	11	,	,	,
cord-254895-ym0jsir5	61	12	via	via	IN
cord-254895-ym0jsir5	61	13	TLR9	TLR9	NNP
cord-254895-ym0jsir5	61	14	,	,	,
cord-254895-ym0jsir5	61	15	whereas	whereas	IN
cord-254895-ym0jsir5	61	16	Influenza	Influenza	NNP
cord-254895-ym0jsir5	61	17	virus	virus	NN
cord-254895-ym0jsir5	61	18	(	(	-LRB-
cord-254895-ym0jsir5	61	19	Barchet	Barchet	NNP
cord-254895-ym0jsir5	61	20	et	et	NNP
cord-254895-ym0jsir5	61	21	al	al	NNP
cord-254895-ym0jsir5	61	22	.	.	NNP
cord-254895-ym0jsir5	61	23	,	,	,
cord-254895-ym0jsir5	61	24	2005	2005	CD
cord-254895-ym0jsir5	61	25	;	;	:
cord-254895-ym0jsir5	61	26	Diebold	Diebold	NNP
cord-254895-ym0jsir5	61	27	et	et	FW
cord-254895-ym0jsir5	61	28	al	al	NNP
cord-254895-ym0jsir5	61	29	.	.	NNP
cord-254895-ym0jsir5	61	30	,	,	,
cord-254895-ym0jsir5	61	31	2004	2004	CD
cord-254895-ym0jsir5	61	32	)	)	-RRB-
cord-254895-ym0jsir5	61	33	,	,	,
cord-254895-ym0jsir5	61	34	vesicular	vesicular	JJ
cord-254895-ym0jsir5	61	35	stomatitis	stomatitis	NN
cord-254895-ym0jsir5	61	36	virus	virus	NN
cord-254895-ym0jsir5	61	37	(	(	-LRB-
cord-254895-ym0jsir5	61	38	VSV	VSV	NNP
cord-254895-ym0jsir5	61	39	)	)	-RRB-
cord-254895-ym0jsir5	61	40	,	,	,
cord-254895-ym0jsir5	61	41	Newcastle	Newcastle	NNP
cord-254895-ym0jsir5	61	42	disease	disease	NN
cord-254895-ym0jsir5	61	43	virus	virus	NN
cord-254895-ym0jsir5	61	44	(	(	-LRB-
cord-254895-ym0jsir5	61	45	NDV	NDV	NNP
cord-254895-ym0jsir5	61	46	)	)	-RRB-
cord-254895-ym0jsir5	61	47	and	and	CC
cord-254895-ym0jsir5	61	48	Sendai	Sendai	NNP
cord-254895-ym0jsir5	61	49	virus	virus	NN
cord-254895-ym0jsir5	61	50	(	(	-LRB-
cord-254895-ym0jsir5	61	51	SeV	sev	NN
cord-254895-ym0jsir5	61	52	)	)	-RRB-
cord-254895-ym0jsir5	62	1	(	(	-LRB-
cord-254895-ym0jsir5	62	2	Lund	Lund	NNP
cord-254895-ym0jsir5	62	3	et	et	NNP
cord-254895-ym0jsir5	62	4	al	al	NNP
cord-254895-ym0jsir5	62	5	.	.	NNP
cord-254895-ym0jsir5	62	6	,	,	,
cord-254895-ym0jsir5	62	7	2004	2004	CD
cord-254895-ym0jsir5	62	8	)	)	-RRB-
cord-254895-ym0jsir5	62	9	are	be	VBP
cord-254895-ym0jsir5	62	10	recognized	recognize	VBN
cord-254895-ym0jsir5	62	11	by	by	IN
cord-254895-ym0jsir5	62	12	TLR7	TLR7	NNP
cord-254895-ym0jsir5	62	13	in	in	IN
cord-254895-ym0jsir5	62	14	pDCs	pDCs	NNP
cord-254895-ym0jsir5	62	15	.	.	.
cord-254895-ym0jsir5	63	1	Many	many	JJ
cord-254895-ym0jsir5	63	2	viruses	virus	NNS
cord-254895-ym0jsir5	63	3	that	that	WDT
cord-254895-ym0jsir5	63	4	enter	enter	VBP
cord-254895-ym0jsir5	63	5	pDCs	pdcs	NN
cord-254895-ym0jsir5	63	6	and	and	CC
cord-254895-ym0jsir5	63	7	trigger	trigger	NN
cord-254895-ym0jsir5	63	8	TLRs	tlr	NNS
cord-254895-ym0jsir5	63	9	are	be	VBP
cord-254895-ym0jsir5	63	10	prevented	prevent	VBN
cord-254895-ym0jsir5	63	11	from	from	IN
cord-254895-ym0jsir5	63	12	expressing	express	VBG
cord-254895-ym0jsir5	63	13	viral	viral	JJ
cord-254895-ym0jsir5	63	14	genes	gene	NNS
cord-254895-ym0jsir5	63	15	and	and	CC
cord-254895-ym0jsir5	63	16	replicating	replicate	VBG
cord-254895-ym0jsir5	63	17	their	-PRON-	PRP$
cord-254895-ym0jsir5	63	18	genome	genome	NN
cord-254895-ym0jsir5	63	19	.	.	.
cord-254895-ym0jsir5	64	1	Thus	thus	RB
cord-254895-ym0jsir5	64	2	,	,	,
cord-254895-ym0jsir5	64	3	the	the	DT
cord-254895-ym0jsir5	64	4	activation	activation	NN
cord-254895-ym0jsir5	64	5	of	of	IN
cord-254895-ym0jsir5	64	6	the	the	DT
cord-254895-ym0jsir5	64	7	type	type	NN
cord-254895-ym0jsir5	64	8	I	-PRON-	PRP
cord-254895-ym0jsir5	64	9	IFN	IFN	NNP
cord-254895-ym0jsir5	64	10	response	response	NN
cord-254895-ym0jsir5	64	11	in	in	IN
cord-254895-ym0jsir5	64	12	pDCs	pDCs	NNP
cord-254895-ym0jsir5	64	13	most	most	RBS
cord-254895-ym0jsir5	64	14	often	often	RB
cord-254895-ym0jsir5	64	15	is	be	VBZ
cord-254895-ym0jsir5	64	16	not	not	RB
cord-254895-ym0jsir5	64	17	counteracted	counteract	VBN
cord-254895-ym0jsir5	64	18	by	by	IN
cord-254895-ym0jsir5	64	19	viral	viral	JJ
cord-254895-ym0jsir5	64	20	immune	immune	JJ
cord-254895-ym0jsir5	64	21	evasion	evasion	NN
cord-254895-ym0jsir5	64	22	strategies	strategy	NNS
cord-254895-ym0jsir5	64	23	.	.	.
cord-254895-ym0jsir5	65	1	Accordingly	accordingly	RB
cord-254895-ym0jsir5	65	2	,	,	,
cord-254895-ym0jsir5	65	3	active	active	JJ
cord-254895-ym0jsir5	65	4	viral	viral	JJ
cord-254895-ym0jsir5	65	5	replication	replication	NN
cord-254895-ym0jsir5	65	6	is	be	VBZ
cord-254895-ym0jsir5	65	7	not	not	RB
cord-254895-ym0jsir5	65	8	required	require	VBN
cord-254895-ym0jsir5	65	9	for	for	IN
cord-254895-ym0jsir5	65	10	the	the	DT
cord-254895-ym0jsir5	65	11	induction	induction	NN
cord-254895-ym0jsir5	65	12	of	of	IN
cord-254895-ym0jsir5	65	13	type	type	NN
cord-254895-ym0jsir5	65	14	I	-PRON-	PRP
cord-254895-ym0jsir5	65	15	IFN	IFN	NNP
cord-254895-ym0jsir5	65	16	production	production	NN
cord-254895-ym0jsir5	65	17	in	in	IN
cord-254895-ym0jsir5	65	18	pDCs	pDCs	NNP
cord-254895-ym0jsir5	65	19	for	for	IN
cord-254895-ym0jsir5	65	20	many	many	JJ
cord-254895-ym0jsir5	65	21	enveloped	envelop	VBN
cord-254895-ym0jsir5	65	22	viruses	virus	NNS
cord-254895-ym0jsir5	65	23	,	,	,
cord-254895-ym0jsir5	65	24	for	for	IN
cord-254895-ym0jsir5	65	25	example	example	NN
cord-254895-ym0jsir5	65	26	Influenza	Influenza	NNP
cord-254895-ym0jsir5	65	27	virus	virus	NN
cord-254895-ym0jsir5	65	28	or	or	CC
cord-254895-ym0jsir5	65	29	herpes	herpes	NN
cord-254895-ym0jsir5	65	30	viruses	virus	NNS
cord-254895-ym0jsir5	66	1	(	(	-LRB-
cord-254895-ym0jsir5	66	2	Krug	Krug	NNP
cord-254895-ym0jsir5	66	3	et	et	NNP
cord-254895-ym0jsir5	66	4	al	al	NNP
cord-254895-ym0jsir5	66	5	.	.	NNP
cord-254895-ym0jsir5	66	6	,	,	,
cord-254895-ym0jsir5	66	7	2004b	2004b	CD
cord-254895-ym0jsir5	66	8	;	;	:
cord-254895-ym0jsir5	66	9	Lund	Lund	NNP
cord-254895-ym0jsir5	66	10	et	et	NNP
cord-254895-ym0jsir5	66	11	al	al	NNP
cord-254895-ym0jsir5	66	12	.	.	NNP
cord-254895-ym0jsir5	66	13	,	,	,
cord-254895-ym0jsir5	66	14	2003	2003	CD
cord-254895-ym0jsir5	66	15	)	)	-RRB-
cord-254895-ym0jsir5	66	16	.	.	.
cord-254895-ym0jsir5	67	1	Following	follow	VBG
cord-254895-ym0jsir5	67	2	endocytic	endocytic	JJ
cord-254895-ym0jsir5	67	3	uptake	uptake	NN
cord-254895-ym0jsir5	67	4	it	-PRON-	PRP
cord-254895-ym0jsir5	67	5	is	be	VBZ
cord-254895-ym0jsir5	67	6	assumed	assume	VBN
cord-254895-ym0jsir5	67	7	that	that	IN
cord-254895-ym0jsir5	67	8	these	these	DT
cord-254895-ym0jsir5	67	9	viruses	virus	NNS
cord-254895-ym0jsir5	67	10	are	be	VBP
cord-254895-ym0jsir5	67	11	retained	retain	VBN
cord-254895-ym0jsir5	67	12	in	in	IN
cord-254895-ym0jsir5	67	13	acidified	acidify	VBN
cord-254895-ym0jsir5	67	14	endosomal	endosomal	NNP
cord-254895-ym0jsir5	67	15	compartments	compartment	NNS
cord-254895-ym0jsir5	67	16	,	,	,
cord-254895-ym0jsir5	67	17	where	where	WRB
cord-254895-ym0jsir5	67	18	TLR7	TLR7	NNP
cord-254895-ym0jsir5	67	19	and	and	CC
cord-254895-ym0jsir5	67	20	TLR9	TLR9	NNP
cord-254895-ym0jsir5	67	21	are	be	VBP
cord-254895-ym0jsir5	67	22	localized	localize	VBN
cord-254895-ym0jsir5	67	23	,	,	,
cord-254895-ym0jsir5	67	24	so	so	IN
cord-254895-ym0jsir5	67	25	that	that	IN
cord-254895-ym0jsir5	67	26	the	the	DT
cord-254895-ym0jsir5	67	27	viral	viral	JJ
cord-254895-ym0jsir5	67	28	particles	particle	NNS
cord-254895-ym0jsir5	67	29	are	be	VBP
cord-254895-ym0jsir5	67	30	degraded	degrade	VBN
cord-254895-ym0jsir5	67	31	and	and	CC
cord-254895-ym0jsir5	67	32	viral	viral	JJ
cord-254895-ym0jsir5	67	33	nucleic	nucleic	JJ
cord-254895-ym0jsir5	67	34	acids	acid	NNS
cord-254895-ym0jsir5	67	35	come	come	VBP
cord-254895-ym0jsir5	67	36	into	into	IN
cord-254895-ym0jsir5	67	37	contact	contact	NN
cord-254895-ym0jsir5	67	38	with	with	IN
cord-254895-ym0jsir5	67	39	TLR7	TLR7	NNP
cord-254895-ym0jsir5	67	40	and	and	CC
cord-254895-ym0jsir5	67	41	TLR9	TLR9	NNP
cord-254895-ym0jsir5	67	42	.	.	.
cord-254895-ym0jsir5	68	1	A	a	DT
cord-254895-ym0jsir5	68	2	recent	recent	JJ
cord-254895-ym0jsir5	68	3	report	report	NN
cord-254895-ym0jsir5	68	4	,	,	,
cord-254895-ym0jsir5	68	5	however	however	RB
cord-254895-ym0jsir5	68	6	,	,	,
cord-254895-ym0jsir5	68	7	clearly	clearly	RB
cord-254895-ym0jsir5	68	8	demonstrates	demonstrate	VBZ
cord-254895-ym0jsir5	68	9	that	that	IN
cord-254895-ym0jsir5	68	10	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	68	11	viral	viral	JJ
cord-254895-ym0jsir5	68	12	replication	replication	NN
cord-254895-ym0jsir5	68	13	and	and	CC
cord-254895-ym0jsir5	68	14	a	a	DT
cord-254895-ym0jsir5	68	15	transport	transport	NN
cord-254895-ym0jsir5	68	16	mechanism	mechanism	NN
cord-254895-ym0jsir5	68	17	involving	involve	VBG
cord-254895-ym0jsir5	68	18	autophagy	autophagy	NN
cord-254895-ym0jsir5	68	19	is	be	VBZ
cord-254895-ym0jsir5	68	20	necessary	necessary	JJ
cord-254895-ym0jsir5	68	21	for	for	IN
cord-254895-ym0jsir5	68	22	triggering	trigger	VBG
cord-254895-ym0jsir5	68	23	the	the	DT
cord-254895-ym0jsir5	68	24	TLR7-dependent	TLR7-dependent	NNP
cord-254895-ym0jsir5	68	25	response	response	NN
cord-254895-ym0jsir5	68	26	to	to	IN
cord-254895-ym0jsir5	68	27	other	other	JJ
cord-254895-ym0jsir5	68	28	RNA	RNA	NNP
cord-254895-ym0jsir5	68	29	viruses	virus	NNS
cord-254895-ym0jsir5	68	30	,	,	,
cord-254895-ym0jsir5	68	31	such	such	JJ
cord-254895-ym0jsir5	68	32	as	as	IN
cord-254895-ym0jsir5	68	33	VSV	VSV	NNP
cord-254895-ym0jsir5	68	34	or	or	CC
cord-254895-ym0jsir5	68	35	SeV	sev	NN
cord-254895-ym0jsir5	68	36	in	in	IN
cord-254895-ym0jsir5	68	37	pDCs	pDCs	NNP
cord-254895-ym0jsir5	69	1	(	(	-LRB-
cord-254895-ym0jsir5	69	2	Lee	Lee	NNP
cord-254895-ym0jsir5	69	3	et	et	NNP
cord-254895-ym0jsir5	69	4	al	al	NNP
cord-254895-ym0jsir5	69	5	.	.	NNP
cord-254895-ym0jsir5	69	6	,	,	,
cord-254895-ym0jsir5	69	7	2007	2007	CD
cord-254895-ym0jsir5	69	8	)	)	-RRB-
cord-254895-ym0jsir5	69	9	.	.	.
cord-254895-ym0jsir5	70	1	After	after	IN
cord-254895-ym0jsir5	70	2	infection	infection	NN
cord-254895-ym0jsir5	70	3	of	of	IN
cord-254895-ym0jsir5	70	4	pDCs	pdcs	NN
cord-254895-ym0jsir5	70	5	with	with	IN
cord-254895-ym0jsir5	70	6	these	these	DT
cord-254895-ym0jsir5	70	7	RNA	RNA	NNP
cord-254895-ym0jsir5	70	8	viruses	virus	NNS
cord-254895-ym0jsir5	70	9	,	,	,
cord-254895-ym0jsir5	70	10	viral	viral	JJ
cord-254895-ym0jsir5	70	11	replication	replication	NN
cord-254895-ym0jsir5	70	12	intermediates	intermediate	NNS
cord-254895-ym0jsir5	70	13	in	in	IN
cord-254895-ym0jsir5	70	14	the	the	DT
cord-254895-ym0jsir5	70	15	cytosol	cytosol	NN
cord-254895-ym0jsir5	70	16	are	be	VBP
cord-254895-ym0jsir5	70	17	internalized	internalize	VBN
cord-254895-ym0jsir5	70	18	in	in	IN
cord-254895-ym0jsir5	70	19	autophagic	autophagic	NN
cord-254895-ym0jsir5	70	20	vesicles	vesicle	NNS
cord-254895-ym0jsir5	70	21	which	which	WDT
cord-254895-ym0jsir5	70	22	are	be	VBP
cord-254895-ym0jsir5	70	23	then	then	RB
cord-254895-ym0jsir5	70	24	directed	direct	VBN
cord-254895-ym0jsir5	70	25	towards	towards	IN
cord-254895-ym0jsir5	70	26	the	the	DT
cord-254895-ym0jsir5	70	27	TLR7-containing	tlr7-containe	VBG
cord-254895-ym0jsir5	70	28	lysosomes	lysosome	NNS
cord-254895-ym0jsir5	70	29	,	,	,
cord-254895-ym0jsir5	70	30	where	where	WRB
cord-254895-ym0jsir5	70	31	recognition	recognition	NN
cord-254895-ym0jsir5	70	32	of	of	IN
cord-254895-ym0jsir5	70	33	the	the	DT
cord-254895-ym0jsir5	70	34	viral	viral	JJ
cord-254895-ym0jsir5	70	35	RNA	RNA	NNP
cord-254895-ym0jsir5	70	36	occurs	occur	VBZ
cord-254895-ym0jsir5	70	37	(	(	-LRB-
cord-254895-ym0jsir5	71	1	Lee	Lee	NNP
cord-254895-ym0jsir5	71	2	et	et	NNP
cord-254895-ym0jsir5	71	3	al	al	NNP
cord-254895-ym0jsir5	71	4	.	.	NNP
cord-254895-ym0jsir5	71	5	,	,	,
cord-254895-ym0jsir5	71	6	2007	2007	CD
cord-254895-ym0jsir5	71	7	)	)	-RRB-
cord-254895-ym0jsir5	71	8	.	.	.
cord-254895-ym0jsir5	72	1	The	the	DT
cord-254895-ym0jsir5	72	2	Toll	Toll	NNP
cord-254895-ym0jsir5	72	3	-	-	HYPH
cord-254895-ym0jsir5	72	4	like	like	JJ
cord-254895-ym0jsir5	72	5	receptors	receptor	NNS
cord-254895-ym0jsir5	72	6	are	be	VBP
cord-254895-ym0jsir5	72	7	a	a	DT
cord-254895-ym0jsir5	72	8	family	family	NN
cord-254895-ym0jsir5	72	9	of	of	IN
cord-254895-ym0jsir5	72	10	type	type	NN
cord-254895-ym0jsir5	72	11	I	-PRON-	PRP
cord-254895-ym0jsir5	72	12	transmembrane	transmembrane	NN
cord-254895-ym0jsir5	72	13	glycoproteins	glycoprotein	NNS
cord-254895-ym0jsir5	72	14	characterized	characterize	VBN
cord-254895-ym0jsir5	72	15	by	by	IN
cord-254895-ym0jsir5	72	16	the	the	DT
cord-254895-ym0jsir5	72	17	extracellular	extracellular	JJ
cord-254895-ym0jsir5	72	18	leucine	leucine	NN
cord-254895-ym0jsir5	72	19	-	-	HYPH
cord-254895-ym0jsir5	72	20	rich	rich	JJ
cord-254895-ym0jsir5	72	21	-	-	HYPH
cord-254895-ym0jsir5	72	22	repeat	repeat	NN
cord-254895-ym0jsir5	72	23	domain	domain	NN
cord-254895-ym0jsir5	72	24	and	and	CC
cord-254895-ym0jsir5	72	25	the	the	DT
cord-254895-ym0jsir5	72	26	cytoplasmatic	cytoplasmatic	JJ
cord-254895-ym0jsir5	72	27	TIR	TIR	NNP
cord-254895-ym0jsir5	72	28	domain	domain	NN
cord-254895-ym0jsir5	72	29	for	for	IN
cord-254895-ym0jsir5	72	30	downstream	downstream	JJ
cord-254895-ym0jsir5	72	31	signaling	signaling	NN
cord-254895-ym0jsir5	72	32	,	,	,
cord-254895-ym0jsir5	72	33	which	which	WDT
cord-254895-ym0jsir5	72	34	is	be	VBZ
cord-254895-ym0jsir5	72	35	homologous	homologous	JJ
cord-254895-ym0jsir5	72	36	to	to	IN
cord-254895-ym0jsir5	72	37	the	the	DT
cord-254895-ym0jsir5	72	38	TIR	TIR	NNP
cord-254895-ym0jsir5	72	39	domain	domain	NN
cord-254895-ym0jsir5	72	40	of	of	IN
cord-254895-ym0jsir5	72	41	the	the	DT
cord-254895-ym0jsir5	72	42	IL-1	IL-1	NNP
cord-254895-ym0jsir5	72	43	and	and	CC
cord-254895-ym0jsir5	72	44	IL-18	IL-18	NNP
cord-254895-ym0jsir5	72	45	receptors	receptor	NNS
cord-254895-ym0jsir5	72	46	.	.	.
cord-254895-ym0jsir5	73	1	TLR	TLR	NNP
cord-254895-ym0jsir5	73	2	expression	expression	NN
cord-254895-ym0jsir5	73	3	is	be	VBZ
cord-254895-ym0jsir5	73	4	predominantly	predominantly	RB
cord-254895-ym0jsir5	73	5	found	find	VBN
cord-254895-ym0jsir5	73	6	in	in	IN
cord-254895-ym0jsir5	73	7	various	various	JJ
cord-254895-ym0jsir5	73	8	immune	immune	JJ
cord-254895-ym0jsir5	73	9	cells	cell	NNS
cord-254895-ym0jsir5	73	10	like	like	IN
cord-254895-ym0jsir5	73	11	dendritic	dendritic	JJ
cord-254895-ym0jsir5	73	12	cells	cell	NNS
cord-254895-ym0jsir5	73	13	,	,	,
cord-254895-ym0jsir5	73	14	macrophages	macrophage	NNS
cord-254895-ym0jsir5	73	15	,	,	,
cord-254895-ym0jsir5	73	16	B	b	NN
cord-254895-ym0jsir5	73	17	cells	cell	NNS
cord-254895-ym0jsir5	73	18	and	and	CC
cord-254895-ym0jsir5	73	19	some	some	DT
cord-254895-ym0jsir5	73	20	types	type	NNS
cord-254895-ym0jsir5	73	21	of	of	IN
cord-254895-ym0jsir5	73	22	T	t	NN
cord-254895-ym0jsir5	73	23	cells	cell	NNS
cord-254895-ym0jsir5	73	24	.	.	.
cord-254895-ym0jsir5	74	1	Moreover	moreover	RB
cord-254895-ym0jsir5	74	2	TLRs	tlr	NNS
cord-254895-ym0jsir5	74	3	can	can	MD
cord-254895-ym0jsir5	74	4	be	be	VB
cord-254895-ym0jsir5	74	5	expressed	express	VBN
cord-254895-ym0jsir5	74	6	by	by	IN
cord-254895-ym0jsir5	74	7	non	non	JJ
cord-254895-ym0jsir5	74	8	-	-	JJ
cord-254895-ym0jsir5	74	9	immune	immune	JJ
cord-254895-ym0jsir5	74	10	cells	cell	NNS
cord-254895-ym0jsir5	74	11	such	such	JJ
cord-254895-ym0jsir5	74	12	as	as	IN
cord-254895-ym0jsir5	74	13	fibroblasts	fibroblast	NNS
cord-254895-ym0jsir5	74	14	and	and	CC
cord-254895-ym0jsir5	74	15	epithelial	epithelial	JJ
cord-254895-ym0jsir5	74	16	cells	cell	NNS
cord-254895-ym0jsir5	74	17	.	.	.
cord-254895-ym0jsir5	75	1	Among	among	IN
cord-254895-ym0jsir5	75	2	the	the	DT
cord-254895-ym0jsir5	75	3	TLR	TLR	NNP
cord-254895-ym0jsir5	75	4	family	family	NN
cord-254895-ym0jsir5	75	5	a	a	DT
cord-254895-ym0jsir5	75	6	subgroup	subgroup	NN
cord-254895-ym0jsir5	75	7	of	of	IN
cord-254895-ym0jsir5	75	8	mainly	mainly	RB
cord-254895-ym0jsir5	75	9	intracellularly	intracellularly	RB
cord-254895-ym0jsir5	75	10	localized	localize	VBN
cord-254895-ym0jsir5	75	11	TLRs	tlr	NNS
cord-254895-ym0jsir5	75	12	(	(	-LRB-
cord-254895-ym0jsir5	75	13	TLR3	TLR3	NNP
cord-254895-ym0jsir5	75	14	,	,	,
cord-254895-ym0jsir5	75	15	7	7	CD
cord-254895-ym0jsir5	75	16	,	,	,
cord-254895-ym0jsir5	75	17	8	8	CD
cord-254895-ym0jsir5	75	18	,	,	,
cord-254895-ym0jsir5	75	19	9	9	CD
cord-254895-ym0jsir5	75	20	)	)	-RRB-
cord-254895-ym0jsir5	75	21	can	can	MD
cord-254895-ym0jsir5	75	22	be	be	VB
cord-254895-ym0jsir5	75	23	differentiated	differentiate	VBN
cord-254895-ym0jsir5	75	24	from	from	IN
cord-254895-ym0jsir5	75	25	TLRs	tlr	NNS
cord-254895-ym0jsir5	75	26	which	which	WDT
cord-254895-ym0jsir5	75	27	are	be	VBP
cord-254895-ym0jsir5	75	28	expressed	express	VBN
cord-254895-ym0jsir5	75	29	on	on	IN
cord-254895-ym0jsir5	75	30	the	the	DT
cord-254895-ym0jsir5	75	31	cell	cell	NN
cord-254895-ym0jsir5	75	32	surface	surface	NN
cord-254895-ym0jsir5	75	33	(	(	-LRB-
cord-254895-ym0jsir5	75	34	TLR1	TLR1	NNP
cord-254895-ym0jsir5	75	35	,	,	,
cord-254895-ym0jsir5	75	36	2	2	CD
cord-254895-ym0jsir5	75	37	,	,	,
cord-254895-ym0jsir5	75	38	4	4	CD
cord-254895-ym0jsir5	75	39	,	,	,
cord-254895-ym0jsir5	75	40	5	5	CD
cord-254895-ym0jsir5	75	41	,	,	,
cord-254895-ym0jsir5	75	42	6	6	CD
cord-254895-ym0jsir5	75	43	,	,	,
cord-254895-ym0jsir5	75	44	5	5	CD
cord-254895-ym0jsir5	75	45	)	)	-RRB-
cord-254895-ym0jsir5	75	46	.	.	.
cord-254895-ym0jsir5	76	1	Whereas	whereas	IN
cord-254895-ym0jsir5	76	2	surfaceexpressed	surfaceexpressed	JJ
cord-254895-ym0jsir5	76	3	TLRs	tlr	NNS
cord-254895-ym0jsir5	76	4	are	be	VBP
cord-254895-ym0jsir5	76	5	mainly	mainly	RB
cord-254895-ym0jsir5	76	6	involved	involve	VBN
cord-254895-ym0jsir5	76	7	in	in	IN
cord-254895-ym0jsir5	76	8	the	the	DT
cord-254895-ym0jsir5	76	9	recognition	recognition	NN
cord-254895-ym0jsir5	76	10	of	of	IN
cord-254895-ym0jsir5	76	11	bacterial	bacterial	JJ
cord-254895-ym0jsir5	76	12	and	and	CC
cord-254895-ym0jsir5	76	13	fungal	fungal	JJ
cord-254895-ym0jsir5	76	14	cell	cell	NN
cord-254895-ym0jsir5	76	15	wall	wall	NN
cord-254895-ym0jsir5	76	16	components	component	NNS
cord-254895-ym0jsir5	76	17	as	as	RB
cord-254895-ym0jsir5	76	18	well	well	RB
cord-254895-ym0jsir5	76	19	as	as	IN
cord-254895-ym0jsir5	76	20	some	some	DT
cord-254895-ym0jsir5	76	21	viral	viral	JJ
cord-254895-ym0jsir5	76	22	proteins	protein	NNS
cord-254895-ym0jsir5	76	23	,	,	,
cord-254895-ym0jsir5	76	24	the	the	DT
cord-254895-ym0jsir5	76	25	intracellular	intracellular	JJ
cord-254895-ym0jsir5	76	26	/	/	SYM
cord-254895-ym0jsir5	76	27	endosomal	endosomal	NNP
cord-254895-ym0jsir5	76	28	TLRs	tlr	NNS
cord-254895-ym0jsir5	76	29	have	have	VBP
cord-254895-ym0jsir5	76	30	the	the	DT
cord-254895-ym0jsir5	76	31	capacity	capacity	NN
cord-254895-ym0jsir5	76	32	to	to	TO
cord-254895-ym0jsir5	76	33	detect	detect	VB
cord-254895-ym0jsir5	76	34	microbial	microbial	JJ
cord-254895-ym0jsir5	76	35	nucleic	nucleic	JJ
cord-254895-ym0jsir5	76	36	acids	acid	NNS
cord-254895-ym0jsir5	76	37	,	,	,
cord-254895-ym0jsir5	76	38	particularly	particularly	RB
cord-254895-ym0jsir5	76	39	viral	viral	JJ
cord-254895-ym0jsir5	76	40	DNA	DNA	NNP
cord-254895-ym0jsir5	76	41	and	and	CC
cord-254895-ym0jsir5	76	42	RNA	RNA	NNP
cord-254895-ym0jsir5	76	43	.	.	.
cord-254895-ym0jsir5	77	1	Apart	apart	RB
cord-254895-ym0jsir5	77	2	from	from	IN
cord-254895-ym0jsir5	77	3	activating	activate	VBG
cord-254895-ym0jsir5	77	4	the	the	DT
cord-254895-ym0jsir5	77	5	NFkB	NFkB	NNPS
cord-254895-ym0jsir5	77	6	and	and	CC
cord-254895-ym0jsir5	77	7	MAPK	MAPK	NNP
cord-254895-ym0jsir5	77	8	signaling	signal	VBG
cord-254895-ym0jsir5	77	9	pathways	pathway	NNS
cord-254895-ym0jsir5	77	10	leading	lead	VBG
cord-254895-ym0jsir5	77	11	to	to	IN
cord-254895-ym0jsir5	77	12	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	77	13	cytokine	cytokine	NN
cord-254895-ym0jsir5	77	14	and	and	CC
cord-254895-ym0jsir5	77	15	chemokine	chemokine	NN
cord-254895-ym0jsir5	77	16	production	production	NN
cord-254895-ym0jsir5	77	17	as	as	RB
cord-254895-ym0jsir5	77	18	well	well	RB
cord-254895-ym0jsir5	77	19	as	as	IN
cord-254895-ym0jsir5	77	20	costimulatory	costimulatory	NNP
cord-254895-ym0jsir5	77	21	molecule	molecule	NN
cord-254895-ym0jsir5	77	22	expression	expression	NN
cord-254895-ym0jsir5	77	23	,	,	,
cord-254895-ym0jsir5	77	24	the	the	DT
cord-254895-ym0jsir5	77	25	intracellularly	intracellularly	RB
cord-254895-ym0jsir5	77	26	localized	localize	VBN
cord-254895-ym0jsir5	77	27	nucleic	nucleic	JJ
cord-254895-ym0jsir5	77	28	acid	acid	NN
cord-254895-ym0jsir5	77	29	recognition	recognition	NN
cord-254895-ym0jsir5	77	30	receptors	receptor	NNS
cord-254895-ym0jsir5	77	31	TLR3	TLR3	NNP
cord-254895-ym0jsir5	77	32	,	,	,
cord-254895-ym0jsir5	77	33	7	7	CD
cord-254895-ym0jsir5	77	34	,	,	,
cord-254895-ym0jsir5	77	35	8	8	CD
cord-254895-ym0jsir5	77	36	and	and	CC
cord-254895-ym0jsir5	77	37	9	9	CD
cord-254895-ym0jsir5	77	38	specifically	specifically	RB
cord-254895-ym0jsir5	77	39	trigger	trigger	NN
cord-254895-ym0jsir5	77	40	type	type	NN
cord-254895-ym0jsir5	78	1	I	-PRON-	PRP
cord-254895-ym0jsir5	79	1	interferon	interferon	NN
cord-254895-ym0jsir5	79	2	production	production	NN
cord-254895-ym0jsir5	79	3	via	via	IN
cord-254895-ym0jsir5	79	4	MyD88-and	myd88-and	JJ
cord-254895-ym0jsir5	79	5	TRIF	trif	NN
cord-254895-ym0jsir5	79	6	-	-	HYPH
cord-254895-ym0jsir5	79	7	dependent	dependent	JJ
cord-254895-ym0jsir5	79	8	signaling	signal	VBG
cord-254895-ym0jsir5	79	9	pathways	pathway	NNS
cord-254895-ym0jsir5	79	10	.	.	.
cord-254895-ym0jsir5	80	1	TLR3	TLR3	NNP
cord-254895-ym0jsir5	80	2	binds	bind	VBZ
cord-254895-ym0jsir5	80	3	double	double	RB
cord-254895-ym0jsir5	80	4	-	-	HYPH
cord-254895-ym0jsir5	80	5	stranded	stranded	JJ
cord-254895-ym0jsir5	80	6	(	(	-LRB-
cord-254895-ym0jsir5	80	7	ds	ds	NNP
cord-254895-ym0jsir5	80	8	)	)	-RRB-
cord-254895-ym0jsir5	80	9	RNA	RNA	NNP
cord-254895-ym0jsir5	80	10	which	which	WDT
cord-254895-ym0jsir5	80	11	is	be	VBZ
cord-254895-ym0jsir5	80	12	found	find	VBN
cord-254895-ym0jsir5	80	13	in	in	IN
cord-254895-ym0jsir5	80	14	dsRNA	dsrna	NN
cord-254895-ym0jsir5	80	15	viruses	virus	NNS
cord-254895-ym0jsir5	80	16	,	,	,
cord-254895-ym0jsir5	80	17	such	such	JJ
cord-254895-ym0jsir5	80	18	as	as	IN
cord-254895-ym0jsir5	80	19	reovirus	reovirus	NNP
cord-254895-ym0jsir5	80	20	,	,	,
cord-254895-ym0jsir5	80	21	or	or	CC
cord-254895-ym0jsir5	80	22	is	be	VBZ
cord-254895-ym0jsir5	80	23	generated	generate	VBN
cord-254895-ym0jsir5	80	24	during	during	IN
cord-254895-ym0jsir5	80	25	replication	replication	NN
cord-254895-ym0jsir5	80	26	of	of	IN
cord-254895-ym0jsir5	80	27	single	single	RB
cord-254895-ym0jsir5	80	28	-	-	HYPH
cord-254895-ym0jsir5	80	29	stranded	stranded	JJ
cord-254895-ym0jsir5	80	30	(	(	-LRB-
cord-254895-ym0jsir5	80	31	ss	ss	NNP
cord-254895-ym0jsir5	80	32	)	)	-RRB-
cord-254895-ym0jsir5	80	33	RNA	RNA	NNP
cord-254895-ym0jsir5	80	34	viruses	virus	NNS
cord-254895-ym0jsir5	80	35	such	such	JJ
cord-254895-ym0jsir5	80	36	as	as	IN
cord-254895-ym0jsir5	80	37	West	West	NNP
cord-254895-ym0jsir5	80	38	Nile	Nile	NNP
cord-254895-ym0jsir5	80	39	virus	virus	NN
cord-254895-ym0jsir5	80	40	(	(	-LRB-
cord-254895-ym0jsir5	80	41	Wang	Wang	NNP
cord-254895-ym0jsir5	80	42	et	et	NNP
cord-254895-ym0jsir5	80	43	al	al	NNP
cord-254895-ym0jsir5	80	44	.	.	NNP
cord-254895-ym0jsir5	80	45	,	,	,
cord-254895-ym0jsir5	80	46	2004	2004	CD
cord-254895-ym0jsir5	80	47	)	)	-RRB-
cord-254895-ym0jsir5	80	48	or	or	CC
cord-254895-ym0jsir5	80	49	respiratory	respiratory	JJ
cord-254895-ym0jsir5	80	50	syncytial	syncytial	JJ
cord-254895-ym0jsir5	80	51	virus	virus	NN
cord-254895-ym0jsir5	81	1	(	(	-LRB-
cord-254895-ym0jsir5	81	2	Rudd	Rudd	NNP
cord-254895-ym0jsir5	81	3	et	et	NNP
cord-254895-ym0jsir5	81	4	al	al	NNP
cord-254895-ym0jsir5	81	5	.	.	NNP
cord-254895-ym0jsir5	81	6	,	,	,
cord-254895-ym0jsir5	81	7	2006	2006	CD
cord-254895-ym0jsir5	81	8	)	)	-RRB-
cord-254895-ym0jsir5	81	9	or	or	CC
cord-254895-ym0jsir5	81	10	as	as	IN
cord-254895-ym0jsir5	81	11	a	a	DT
cord-254895-ym0jsir5	81	12	by	by	IN
cord-254895-ym0jsir5	81	13	-	-	HYPH
cord-254895-ym0jsir5	81	14	product	product	NN
cord-254895-ym0jsir5	81	15	of	of	IN
cord-254895-ym0jsir5	81	16	symmetrical	symmetrical	JJ
cord-254895-ym0jsir5	81	17	transcription	transcription	NN
cord-254895-ym0jsir5	81	18	of	of	IN
cord-254895-ym0jsir5	81	19	viral	viral	JJ
cord-254895-ym0jsir5	81	20	DNA	dna	NN
cord-254895-ym0jsir5	81	21	,	,	,
cord-254895-ym0jsir5	81	22	for	for	IN
cord-254895-ym0jsir5	81	23	example	example	NN
cord-254895-ym0jsir5	81	24	from	from	IN
cord-254895-ym0jsir5	81	25	herpes	herpes	NN
cord-254895-ym0jsir5	81	26	viruses	virus	NNS
cord-254895-ym0jsir5	81	27	.	.	.
cord-254895-ym0jsir5	82	1	Another	another	DT
cord-254895-ym0jsir5	82	2	ligand	ligand	NN
cord-254895-ym0jsir5	82	3	for	for	IN
cord-254895-ym0jsir5	82	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	82	5	is	be	VBZ
cord-254895-ym0jsir5	82	6	poly(I	poly(i	NN
cord-254895-ym0jsir5	82	7	:	:	:
cord-254895-ym0jsir5	82	8	C	C	NNP
cord-254895-ym0jsir5	82	9	)	)	-RRB-
cord-254895-ym0jsir5	82	10	which	which	WDT
cord-254895-ym0jsir5	82	11	is	be	VBZ
cord-254895-ym0jsir5	82	12	a	a	DT
cord-254895-ym0jsir5	82	13	synthetic	synthetic	JJ
cord-254895-ym0jsir5	82	14	dsRNA	dsrna	JJ
cord-254895-ym0jsir5	82	15	mimicking	mimic	VBG
cord-254895-ym0jsir5	82	16	viral	viral	JJ
cord-254895-ym0jsir5	82	17	infection	infection	NN
cord-254895-ym0jsir5	83	1	(	(	-LRB-
cord-254895-ym0jsir5	83	2	Alexopoulou	Alexopoulou	NNP
cord-254895-ym0jsir5	83	3	et	et	NNP
cord-254895-ym0jsir5	83	4	al	al	NNP
cord-254895-ym0jsir5	83	5	.	.	NNP
cord-254895-ym0jsir5	83	6	,	,	,
cord-254895-ym0jsir5	83	7	2001	2001	CD
cord-254895-ym0jsir5	83	8	)	)	-RRB-
cord-254895-ym0jsir5	83	9	.	.	.
cord-254895-ym0jsir5	84	1	Studies	study	NNS
cord-254895-ym0jsir5	84	2	in	in	IN
cord-254895-ym0jsir5	84	3	TLR3	TLR3	NNP
cord-254895-ym0jsir5	84	4	À	à	NN
cord-254895-ym0jsir5	84	5	/	/	SYM
cord-254895-ym0jsir5	84	6	À	à	NN
cord-254895-ym0jsir5	84	7	mice	mouse	NNS
cord-254895-ym0jsir5	84	8	identified	identify	VBD
cord-254895-ym0jsir5	84	9	poly(I	poly(I	NNP
cord-254895-ym0jsir5	84	10	:	:	:
cord-254895-ym0jsir5	84	11	C	C	NNP
cord-254895-ym0jsir5	84	12	)	)	-RRB-
cord-254895-ym0jsir5	84	13	and	and	CC
cord-254895-ym0jsir5	84	14	dsRNA	dsrna	NN
cord-254895-ym0jsir5	84	15	as	as	IN
cord-254895-ym0jsir5	84	16	ligands	ligand	NNS
cord-254895-ym0jsir5	84	17	for	for	IN
cord-254895-ym0jsir5	84	18	TLR3	TLR3	NNP
cord-254895-ym0jsir5	84	19	,	,	,
cord-254895-ym0jsir5	84	20	which	which	WDT
cord-254895-ym0jsir5	84	21	induce	induce	VBP
cord-254895-ym0jsir5	84	22	type	type	NN
cord-254895-ym0jsir5	85	1	I	-PRON-	PRP
cord-254895-ym0jsir5	85	2	IFN	IFN	NNP
cord-254895-ym0jsir5	85	3	and	and	CC
cord-254895-ym0jsir5	85	4	proinflammatory	proinflammatory	JJ
cord-254895-ym0jsir5	85	5	cytokine	cytokine	NN
cord-254895-ym0jsir5	85	6	production	production	NN
cord-254895-ym0jsir5	85	7	.	.	.
cord-254895-ym0jsir5	86	1	Up	up	IN
cord-254895-ym0jsir5	86	2	-	-	HYPH
cord-254895-ym0jsir5	86	3	regulation	regulation	NN
cord-254895-ym0jsir5	86	4	of	of	IN
cord-254895-ym0jsir5	86	5	TLR3	tlr3	CD
cord-254895-ym0jsir5	86	6	expression	expression	NN
cord-254895-ym0jsir5	86	7	by	by	IN
cord-254895-ym0jsir5	86	8	type	type	NN
cord-254895-ym0jsir5	87	1	I	-PRON-	PRP
cord-254895-ym0jsir5	87	2	IFN	IFN	NNP
cord-254895-ym0jsir5	87	3	amplifies	amplify	VBZ
cord-254895-ym0jsir5	87	4	the	the	DT
cord-254895-ym0jsir5	87	5	response	response	NN
cord-254895-ym0jsir5	87	6	to	to	IN
cord-254895-ym0jsir5	87	7	TLR3	TLR3	NNP
cord-254895-ym0jsir5	87	8	ligands	ligand	NNS
cord-254895-ym0jsir5	87	9	.	.	.
cord-254895-ym0jsir5	88	1	TLR3	TLR3	NNP
cord-254895-ym0jsir5	88	2	is	be	VBZ
cord-254895-ym0jsir5	88	3	expressed	express	VBN
cord-254895-ym0jsir5	88	4	in	in	IN
cord-254895-ym0jsir5	88	5	conventional	conventional	JJ
cord-254895-ym0jsir5	88	6	DC	DC	NNP
cord-254895-ym0jsir5	88	7	(	(	-LRB-
cord-254895-ym0jsir5	88	8	cDCs	cDCs	NNP
cord-254895-ym0jsir5	88	9	)	)	-RRB-
cord-254895-ym0jsir5	88	10	subpopulations	subpopulation	NNS
cord-254895-ym0jsir5	88	11	and	and	CC
cord-254895-ym0jsir5	88	12	macrophages	macrophage	NNS
cord-254895-ym0jsir5	88	13	as	as	RB
cord-254895-ym0jsir5	88	14	well	well	RB
cord-254895-ym0jsir5	88	15	as	as	IN
cord-254895-ym0jsir5	88	16	nonimmune	nonimmune	JJ
cord-254895-ym0jsir5	88	17	cells	cell	NNS
cord-254895-ym0jsir5	88	18	,	,	,
cord-254895-ym0jsir5	88	19	such	such	JJ
cord-254895-ym0jsir5	88	20	as	as	IN
cord-254895-ym0jsir5	88	21	fibroblasts	fibroblast	NNS
cord-254895-ym0jsir5	88	22	and	and	CC
cord-254895-ym0jsir5	88	23	epithelial	epithelial	JJ
cord-254895-ym0jsir5	88	24	cells	cell	NNS
cord-254895-ym0jsir5	88	25	,	,	,
cord-254895-ym0jsir5	88	26	and	and	CC
cord-254895-ym0jsir5	88	27	the	the	DT
cord-254895-ym0jsir5	88	28	cellular	cellular	JJ
cord-254895-ym0jsir5	88	29	localization	localization	NN
cord-254895-ym0jsir5	88	30	of	of	IN
cord-254895-ym0jsir5	88	31	TLR3	TLR3	NNP
cord-254895-ym0jsir5	88	32	varies	vary	VBZ
cord-254895-ym0jsir5	88	33	between	between	IN
cord-254895-ym0jsir5	88	34	different	different	JJ
cord-254895-ym0jsir5	88	35	cell	cell	NN
cord-254895-ym0jsir5	88	36	types	type	NNS
cord-254895-ym0jsir5	88	37	.	.	.
cord-254895-ym0jsir5	89	1	In	in	IN
cord-254895-ym0jsir5	89	2	conventional	conventional	JJ
cord-254895-ym0jsir5	89	3	DCs	dc	NNS
cord-254895-ym0jsir5	89	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	89	5	is	be	VBZ
cord-254895-ym0jsir5	89	6	thought	think	VBN
cord-254895-ym0jsir5	89	7	to	to	TO
cord-254895-ym0jsir5	89	8	be	be	VB
cord-254895-ym0jsir5	89	9	localized	localize	VBN
cord-254895-ym0jsir5	89	10	in	in	IN
cord-254895-ym0jsir5	89	11	intracellular	intracellular	JJ
cord-254895-ym0jsir5	89	12	vesicular	vesicular	JJ
cord-254895-ym0jsir5	89	13	structures	structure	NNS
cord-254895-ym0jsir5	89	14	(	(	-LRB-
cord-254895-ym0jsir5	89	15	Matsumoto	Matsumoto	NNP
cord-254895-ym0jsir5	89	16	et	et	NNP
cord-254895-ym0jsir5	89	17	al	al	NNP
cord-254895-ym0jsir5	89	18	.	.	NNP
cord-254895-ym0jsir5	89	19	,	,	,
cord-254895-ym0jsir5	89	20	2003	2003	CD
cord-254895-ym0jsir5	89	21	)	)	-RRB-
cord-254895-ym0jsir5	89	22	.	.	.
cord-254895-ym0jsir5	90	1	High	high	JJ
cord-254895-ym0jsir5	90	2	expression	expression	NN
cord-254895-ym0jsir5	90	3	of	of	IN
cord-254895-ym0jsir5	90	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	90	5	is	be	VBZ
cord-254895-ym0jsir5	90	6	seen	see	VBN
cord-254895-ym0jsir5	90	7	in	in	IN
cord-254895-ym0jsir5	90	8	the	the	DT
cord-254895-ym0jsir5	90	9	subset	subset	NN
cord-254895-ym0jsir5	90	10	of	of	IN
cord-254895-ym0jsir5	90	11	CD8a	CD8a	NNP
cord-254895-ym0jsir5	90	12	+	+	SYM
cord-254895-ym0jsir5	90	13	CD4	CD4	NNP
cord-254895-ym0jsir5	90	14	À	À	NNP
cord-254895-ym0jsir5	90	15	DC	DC	NNP
cord-254895-ym0jsir5	90	16	which	which	WDT
cord-254895-ym0jsir5	90	17	phagocytose	phagocytose	VBD
cord-254895-ym0jsir5	90	18	apoptotic	apoptotic	JJ
cord-254895-ym0jsir5	90	19	cells	cell	NNS
cord-254895-ym0jsir5	90	20	,	,	,
cord-254895-ym0jsir5	90	21	including	include	VBG
cord-254895-ym0jsir5	90	22	dying	die	VBG
cord-254895-ym0jsir5	90	23	cells	cell	NNS
cord-254895-ym0jsir5	90	24	that	that	WDT
cord-254895-ym0jsir5	90	25	are	be	VBP
cord-254895-ym0jsir5	90	26	infected	infect	VBN
cord-254895-ym0jsir5	90	27	by	by	IN
cord-254895-ym0jsir5	90	28	RNA	RNA	NNP
cord-254895-ym0jsir5	90	29	viruses	virus	NNS
cord-254895-ym0jsir5	90	30	(	(	-LRB-
cord-254895-ym0jsir5	90	31	Edwards	Edwards	NNP
cord-254895-ym0jsir5	90	32	et	et	NNP
cord-254895-ym0jsir5	90	33	al	al	NNP
cord-254895-ym0jsir5	90	34	.	.	NNP
cord-254895-ym0jsir5	90	35	,	,	,
cord-254895-ym0jsir5	90	36	2003	2003	CD
cord-254895-ym0jsir5	90	37	)	)	-RRB-
cord-254895-ym0jsir5	90	38	.	.	.
cord-254895-ym0jsir5	91	1	In	in	IN
cord-254895-ym0jsir5	91	2	other	other	JJ
cord-254895-ym0jsir5	91	3	cell	cell	NN
cord-254895-ym0jsir5	91	4	types	type	NNS
cord-254895-ym0jsir5	91	5	such	such	JJ
cord-254895-ym0jsir5	91	6	as	as	IN
cord-254895-ym0jsir5	91	7	fibroblasts	fibroblast	NNS
cord-254895-ym0jsir5	91	8	or	or	CC
cord-254895-ym0jsir5	91	9	epithelial	epithelial	JJ
cord-254895-ym0jsir5	91	10	cells	cell	NNS
cord-254895-ym0jsir5	92	1	TLR3	TLR3	NNP
cord-254895-ym0jsir5	92	2	is	be	VBZ
cord-254895-ym0jsir5	92	3	expressed	express	VBN
cord-254895-ym0jsir5	92	4	on	on	IN
cord-254895-ym0jsir5	92	5	the	the	DT
cord-254895-ym0jsir5	92	6	cell	cell	NN
cord-254895-ym0jsir5	92	7	surface	surface	NN
cord-254895-ym0jsir5	92	8	(	(	-LRB-
cord-254895-ym0jsir5	92	9	Matsumoto	Matsumoto	NNP
cord-254895-ym0jsir5	92	10	et	et	NNP
cord-254895-ym0jsir5	92	11	al	al	NNP
cord-254895-ym0jsir5	92	12	.	.	NNP
cord-254895-ym0jsir5	92	13	,	,	,
cord-254895-ym0jsir5	92	14	2003	2003	CD
cord-254895-ym0jsir5	92	15	)	)	-RRB-
cord-254895-ym0jsir5	92	16	.	.	.
cord-254895-ym0jsir5	93	1	Epithelial	epithelial	JJ
cord-254895-ym0jsir5	93	2	expression	expression	NN
cord-254895-ym0jsir5	93	3	of	of	IN
cord-254895-ym0jsir5	93	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	93	5	can	can	MD
cord-254895-ym0jsir5	93	6	be	be	VB
cord-254895-ym0jsir5	93	7	found	find	VBN
cord-254895-ym0jsir5	93	8	in	in	IN
cord-254895-ym0jsir5	93	9	many	many	JJ
cord-254895-ym0jsir5	93	10	different	different	JJ
cord-254895-ym0jsir5	93	11	organs	organ	NNS
cord-254895-ym0jsir5	93	12	including	include	VBG
cord-254895-ym0jsir5	93	13	the	the	DT
cord-254895-ym0jsir5	93	14	airways	airway	NNS
cord-254895-ym0jsir5	93	15	as	as	RB
cord-254895-ym0jsir5	93	16	well	well	RB
cord-254895-ym0jsir5	93	17	as	as	IN
cord-254895-ym0jsir5	93	18	the	the	DT
cord-254895-ym0jsir5	93	19	gastrointestinal	gastrointestinal	JJ
cord-254895-ym0jsir5	93	20	and	and	CC
cord-254895-ym0jsir5	93	21	urogenital	urogenital	JJ
cord-254895-ym0jsir5	93	22	system	system	NN
cord-254895-ym0jsir5	93	23	.	.	.
cord-254895-ym0jsir5	94	1	Furthermore	furthermore	RB
cord-254895-ym0jsir5	94	2	,	,	,
cord-254895-ym0jsir5	94	3	strong	strong	JJ
cord-254895-ym0jsir5	94	4	expression	expression	NN
cord-254895-ym0jsir5	94	5	of	of	IN
cord-254895-ym0jsir5	94	6	TLR3	TLR3	NNP
cord-254895-ym0jsir5	94	7	is	be	VBZ
cord-254895-ym0jsir5	94	8	detectable	detectable	JJ
cord-254895-ym0jsir5	94	9	in	in	IN
cord-254895-ym0jsir5	94	10	the	the	DT
cord-254895-ym0jsir5	94	11	brain	brain	NN
cord-254895-ym0jsir5	94	12	suggesting	suggest	VBG
cord-254895-ym0jsir5	94	13	a	a	DT
cord-254895-ym0jsir5	94	14	specific	specific	JJ
cord-254895-ym0jsir5	94	15	role	role	NN
cord-254895-ym0jsir5	94	16	in	in	IN
cord-254895-ym0jsir5	94	17	response	response	NN
cord-254895-ym0jsir5	94	18	to	to	IN
cord-254895-ym0jsir5	94	19	viral	viral	JJ
cord-254895-ym0jsir5	94	20	infections	infection	NNS
cord-254895-ym0jsir5	94	21	of	of	IN
cord-254895-ym0jsir5	94	22	the	the	DT
cord-254895-ym0jsir5	94	23	central	central	JJ
cord-254895-ym0jsir5	94	24	nervous	nervous	JJ
cord-254895-ym0jsir5	94	25	system	system	NN
cord-254895-ym0jsir5	94	26	.	.	.
cord-254895-ym0jsir5	95	1	Despite	despite	IN
cord-254895-ym0jsir5	95	2	this	this	DT
cord-254895-ym0jsir5	95	3	wide	wide	JJ
cord-254895-ym0jsir5	95	4	expression	expression	NN
cord-254895-ym0jsir5	95	5	pattern	pattern	NN
cord-254895-ym0jsir5	95	6	TLR3	TLR3	NNP
cord-254895-ym0jsir5	95	7	does	do	VBZ
cord-254895-ym0jsir5	95	8	not	not	RB
cord-254895-ym0jsir5	95	9	appear	appear	VB
cord-254895-ym0jsir5	95	10	to	to	TO
cord-254895-ym0jsir5	95	11	be	be	VB
cord-254895-ym0jsir5	95	12	essential	essential	JJ
cord-254895-ym0jsir5	95	13	for	for	IN
cord-254895-ym0jsir5	95	14	the	the	DT
cord-254895-ym0jsir5	95	15	initial	initial	JJ
cord-254895-ym0jsir5	95	16	antiviral	antiviral	JJ
cord-254895-ym0jsir5	95	17	immune	immune	JJ
cord-254895-ym0jsir5	95	18	response	response	NN
cord-254895-ym0jsir5	95	19	in	in	IN
cord-254895-ym0jsir5	95	20	several	several	JJ
cord-254895-ym0jsir5	95	21	mouse	mouse	NN
cord-254895-ym0jsir5	95	22	models	model	NNS
cord-254895-ym0jsir5	95	23	of	of	IN
cord-254895-ym0jsir5	95	24	viral	viral	JJ
cord-254895-ym0jsir5	95	25	infection	infection	NN
cord-254895-ym0jsir5	96	1	(	(	-LRB-
cord-254895-ym0jsir5	96	2	Edelmann	Edelmann	NNP
cord-254895-ym0jsir5	96	3	et	et	NNP
cord-254895-ym0jsir5	96	4	al	al	NNP
cord-254895-ym0jsir5	96	5	.	.	NNP
cord-254895-ym0jsir5	96	6	,	,	,
cord-254895-ym0jsir5	96	7	2004	2004	CD
cord-254895-ym0jsir5	96	8	;	;	:
cord-254895-ym0jsir5	96	9	Lopez	Lopez	NNP
cord-254895-ym0jsir5	96	10	et	et	NNP
cord-254895-ym0jsir5	96	11	al	al	NNP
cord-254895-ym0jsir5	96	12	.	.	NNP
cord-254895-ym0jsir5	96	13	,	,	,
cord-254895-ym0jsir5	96	14	2004	2004	CD
cord-254895-ym0jsir5	96	15	)	)	-RRB-
cord-254895-ym0jsir5	96	16	.	.	.
cord-254895-ym0jsir5	97	1	Downstream	downstream	JJ
cord-254895-ym0jsir5	97	2	signaling	signaling	NN
cord-254895-ym0jsir5	97	3	of	of	IN
cord-254895-ym0jsir5	97	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	97	5	is	be	VBZ
cord-254895-ym0jsir5	97	6	unique	unique	JJ
cord-254895-ym0jsir5	97	7	among	among	IN
cord-254895-ym0jsir5	97	8	all	all	DT
cord-254895-ym0jsir5	97	9	TLRs	tlr	NNS
cord-254895-ym0jsir5	97	10	,	,	,
cord-254895-ym0jsir5	97	11	because	because	IN
cord-254895-ym0jsir5	97	12	it	-PRON-	PRP
cord-254895-ym0jsir5	97	13	is	be	VBZ
cord-254895-ym0jsir5	97	14	entirely	entirely	RB
cord-254895-ym0jsir5	97	15	MyD88-independent	myd88-independent	JJ
cord-254895-ym0jsir5	97	16	and	and	CC
cord-254895-ym0jsir5	97	17	is	be	VBZ
cord-254895-ym0jsir5	97	18	mediated	mediate	VBN
cord-254895-ym0jsir5	97	19	by	by	IN
cord-254895-ym0jsir5	97	20	the	the	DT
cord-254895-ym0jsir5	97	21	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	97	22	TIR	tir	NN
cord-254895-ym0jsir5	97	23	-	-	HYPH
cord-254895-ym0jsir5	97	24	domain	domain	NN
cord-254895-ym0jsir5	97	25	containing	contain	VBG
cord-254895-ym0jsir5	97	26	adaptor	adaptor	NN
cord-254895-ym0jsir5	97	27	protein	protein	NN
cord-254895-ym0jsir5	97	28	TRIF	TRIF	NNP
cord-254895-ym0jsir5	97	29	.	.	.
cord-254895-ym0jsir5	98	1	TRIF	TRIF	NNP
cord-254895-ym0jsir5	98	2	is	be	VBZ
cord-254895-ym0jsir5	98	3	recruited	recruit	VBN
cord-254895-ym0jsir5	98	4	to	to	IN
cord-254895-ym0jsir5	98	5	the	the	DT
cord-254895-ym0jsir5	98	6	cytoplasmatic	cytoplasmatic	JJ
cord-254895-ym0jsir5	98	7	TIR	TIR	NNP
cord-254895-ym0jsir5	98	8	domain	domain	NN
cord-254895-ym0jsir5	98	9	of	of	IN
cord-254895-ym0jsir5	98	10	TLR3	TLR3	NNP
cord-254895-ym0jsir5	98	11	and	and	CC
cord-254895-ym0jsir5	98	12	interacts	interact	VBZ
cord-254895-ym0jsir5	98	13	with	with	IN
cord-254895-ym0jsir5	98	14	a	a	DT
cord-254895-ym0jsir5	98	15	set	set	NN
cord-254895-ym0jsir5	98	16	of	of	IN
cord-254895-ym0jsir5	98	17	different	different	JJ
cord-254895-ym0jsir5	98	18	signaling	signal	VBG
cord-254895-ym0jsir5	98	19	molecules	molecule	NNS
cord-254895-ym0jsir5	98	20	and	and	CC
cord-254895-ym0jsir5	98	21	kinases	kinase	NNS
cord-254895-ym0jsir5	98	22	which	which	WDT
cord-254895-ym0jsir5	98	23	in	in	IN
cord-254895-ym0jsir5	98	24	turn	turn	NN
cord-254895-ym0jsir5	98	25	initiate	initiate	VBP
cord-254895-ym0jsir5	98	26	activation	activation	NN
cord-254895-ym0jsir5	98	27	of	of	IN
cord-254895-ym0jsir5	98	28	NFkB	NFkB	NNP
cord-254895-ym0jsir5	98	29	or	or	CC
cord-254895-ym0jsir5	98	30	IRF3	IRF3	NNP
cord-254895-ym0jsir5	98	31	and	and	CC
cord-254895-ym0jsir5	98	32	IRF7	IRF7	NNP
cord-254895-ym0jsir5	98	33	leading	lead	VBG
cord-254895-ym0jsir5	98	34	to	to	IN
cord-254895-ym0jsir5	98	35	type	type	NN
cord-254895-ym0jsir5	98	36	I	-PRON-	PRP
cord-254895-ym0jsir5	98	37	interferon	interferon	RB
cord-254895-ym0jsir5	98	38	induction	induction	NN
cord-254895-ym0jsir5	98	39	.	.	.
cord-254895-ym0jsir5	99	1	Interaction	interaction	NN
cord-254895-ym0jsir5	99	2	of	of	IN
cord-254895-ym0jsir5	99	3	TRIF	TRIF	NNP
cord-254895-ym0jsir5	99	4	with	with	IN
cord-254895-ym0jsir5	99	5	TRAF3	TRAF3	NNP
cord-254895-ym0jsir5	99	6	allows	allow	VBZ
cord-254895-ym0jsir5	99	7	complex	complex	JJ
cord-254895-ym0jsir5	99	8	formation	formation	NN
cord-254895-ym0jsir5	99	9	with	with	IN
cord-254895-ym0jsir5	99	10	the	the	DT
cord-254895-ym0jsir5	99	11	non	non	JJ
cord-254895-ym0jsir5	99	12	-	-	JJ
cord-254895-ym0jsir5	99	13	canonical	canonical	JJ
cord-254895-ym0jsir5	99	14	IKKs	ikk	NNS
cord-254895-ym0jsir5	99	15	-	-	HYPH
cord-254895-ym0jsir5	99	16	TBK1	TBK1	NNP
cord-254895-ym0jsir5	99	17	and	and	CC
cord-254895-ym0jsir5	99	18	IKKe	IKKe	NNS
cord-254895-ym0jsir5	99	19	leading	lead	VBG
cord-254895-ym0jsir5	99	20	to	to	IN
cord-254895-ym0jsir5	99	21	the	the	DT
cord-254895-ym0jsir5	99	22	activation	activation	NN
cord-254895-ym0jsir5	99	23	of	of	IN
cord-254895-ym0jsir5	99	24	IRF3	IRF3	NNP
cord-254895-ym0jsir5	99	25	and	and	CC
cord-254895-ym0jsir5	99	26	IRF7	IRF7	NNP
cord-254895-ym0jsir5	99	27	,	,	,
cord-254895-ym0jsir5	99	28	which	which	WDT
cord-254895-ym0jsir5	99	29	form	form	VBP
cord-254895-ym0jsir5	99	30	homo	homo	NN
cord-254895-ym0jsir5	99	31	-	-	:
cord-254895-ym0jsir5	99	32	or	or	CC
cord-254895-ym0jsir5	99	33	heterodimers	heterodimer	NNS
cord-254895-ym0jsir5	99	34	upon	upon	IN
cord-254895-ym0jsir5	99	35	phosphorylation	phosphorylation	NN
cord-254895-ym0jsir5	99	36	and	and	CC
cord-254895-ym0jsir5	99	37	are	be	VBP
cord-254895-ym0jsir5	99	38	then	then	RB
cord-254895-ym0jsir5	99	39	translocated	translocate	VBN
cord-254895-ym0jsir5	99	40	to	to	IN
cord-254895-ym0jsir5	99	41	the	the	DT
cord-254895-ym0jsir5	99	42	nucleus	nucleus	NN
cord-254895-ym0jsir5	99	43	to	to	TO
cord-254895-ym0jsir5	99	44	induce	induce	VB
cord-254895-ym0jsir5	99	45	type	type	NN
cord-254895-ym0jsir5	99	46	I	-PRON-	PRP
cord-254895-ym0jsir5	99	47	IFN	IFN	NNP
cord-254895-ym0jsir5	99	48	and	and	CC
cord-254895-ym0jsir5	99	49	IFN	IFN	NNP
cord-254895-ym0jsir5	99	50	inducible	inducible	JJ
cord-254895-ym0jsir5	99	51	gene	gene	NN
cord-254895-ym0jsir5	99	52	expression	expression	NN
cord-254895-ym0jsir5	99	53	Sharma	Sharma	NNP
cord-254895-ym0jsir5	99	54	et	et	FW
cord-254895-ym0jsir5	99	55	al	al	NNP
cord-254895-ym0jsir5	99	56	.	.	.
cord-254895-ym0jsir5	100	1	,	,	,
cord-254895-ym0jsir5	100	2	2003	2003	CD
cord-254895-ym0jsir5	100	3	;	;	:
cord-254895-ym0jsir5	100	4	Yamamoto	Yamamoto	NNP
cord-254895-ym0jsir5	100	5	et	et	NNP
cord-254895-ym0jsir5	100	6	al	al	NNP
cord-254895-ym0jsir5	100	7	.	.	NNP
cord-254895-ym0jsir5	100	8	,	,	,
cord-254895-ym0jsir5	100	9	2003	2003	CD
cord-254895-ym0jsir5	100	10	)	)	-RRB-
cord-254895-ym0jsir5	100	11	.	.	.
cord-254895-ym0jsir5	101	1	NFkB	nfkb	JJ
cord-254895-ym0jsir5	101	2	activation	activation	NN
cord-254895-ym0jsir5	101	3	by	by	IN
cord-254895-ym0jsir5	101	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	101	5	ligands	ligand	NNS
cord-254895-ym0jsir5	101	6	is	be	VBZ
cord-254895-ym0jsir5	101	7	mediated	mediate	VBN
cord-254895-ym0jsir5	101	8	in	in	IN
cord-254895-ym0jsir5	101	9	two	two	CD
cord-254895-ym0jsir5	101	10	waysvia	waysvia	NNP
cord-254895-ym0jsir5	101	11	association	association	NN
cord-254895-ym0jsir5	101	12	of	of	IN
cord-254895-ym0jsir5	101	13	TRIF	TRIF	NNP
cord-254895-ym0jsir5	101	14	with	with	IN
cord-254895-ym0jsir5	101	15	RIP1	RIP1	NNP
cord-254895-ym0jsir5	101	16	or	or	CC
cord-254895-ym0jsir5	101	17	via	via	IN
cord-254895-ym0jsir5	101	18	interaction	interaction	NN
cord-254895-ym0jsir5	101	19	of	of	IN
cord-254895-ym0jsir5	101	20	TRIF	TRIF	NNP
cord-254895-ym0jsir5	101	21	with	with	IN
cord-254895-ym0jsir5	101	22	TRAF6	TRAF6	NNP
cord-254895-ym0jsir5	101	23	,	,	,
cord-254895-ym0jsir5	101	24	which	which	WDT
cord-254895-ym0jsir5	101	25	in	in	IN
cord-254895-ym0jsir5	101	26	turn	turn	NN
cord-254895-ym0jsir5	101	27	activates	activate	VBZ
cord-254895-ym0jsir5	101	28	TAK1	TAK1	NNP
cord-254895-ym0jsir5	101	29	.	.	.
cord-254895-ym0jsir5	102	1	Both	both	DT
cord-254895-ym0jsir5	102	2	RIP1	RIP1	NNP
cord-254895-ym0jsir5	102	3	and	and	CC
cord-254895-ym0jsir5	102	4	TAK1	TAK1	NNP
cord-254895-ym0jsir5	102	5	mediate	mediate	JJ
cord-254895-ym0jsir5	102	6	activation	activation	NN
cord-254895-ym0jsir5	102	7	of	of	IN
cord-254895-ym0jsir5	102	8	canonical	canonical	JJ
cord-254895-ym0jsir5	102	9	IKKs	ikk	NNS
cord-254895-ym0jsir5	102	10	(	(	-LRB-
cord-254895-ym0jsir5	102	11	IKKa	IKKa	NNS
cord-254895-ym0jsir5	102	12	,	,	,
cord-254895-ym0jsir5	102	13	IKKb	IKKb	NNP
cord-254895-ym0jsir5	102	14	)	)	-RRB-
cord-254895-ym0jsir5	102	15	resulting	result	VBG
cord-254895-ym0jsir5	102	16	in	in	IN
cord-254895-ym0jsir5	102	17	IkB	ikb	NN
cord-254895-ym0jsir5	102	18	degradation	degradation	NN
cord-254895-ym0jsir5	102	19	and	and	CC
cord-254895-ym0jsir5	102	20	NFkB	nfkb	JJ
cord-254895-ym0jsir5	102	21	translocation	translocation	NN
cord-254895-ym0jsir5	102	22	to	to	IN
cord-254895-ym0jsir5	102	23	the	the	DT
cord-254895-ym0jsir5	102	24	nucleus	nucleus	NN
cord-254895-ym0jsir5	103	1	(	(	-LRB-
cord-254895-ym0jsir5	103	2	Meylan	Meylan	NNP
cord-254895-ym0jsir5	103	3	et	et	NNP
cord-254895-ym0jsir5	103	4	al	al	NNP
cord-254895-ym0jsir5	103	5	.	.	NNP
cord-254895-ym0jsir5	103	6	,	,	,
cord-254895-ym0jsir5	103	7	2004	2004	CD
cord-254895-ym0jsir5	103	8	;	;	:
cord-254895-ym0jsir5	103	9	Sato	Sato	NNP
cord-254895-ym0jsir5	103	10	et	et	FW
cord-254895-ym0jsir5	103	11	al	al	NNP
cord-254895-ym0jsir5	103	12	.	.	NNP
cord-254895-ym0jsir5	103	13	,	,	,
cord-254895-ym0jsir5	103	14	2007	2007	CD
cord-254895-ym0jsir5	103	15	)	)	-RRB-
cord-254895-ym0jsir5	103	16	.	.	.
cord-254895-ym0jsir5	104	1	The	the	DT
cord-254895-ym0jsir5	104	2	role	role	NN
cord-254895-ym0jsir5	104	3	of	of	IN
cord-254895-ym0jsir5	104	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	104	5	in	in	IN
cord-254895-ym0jsir5	104	6	antiviral	antiviral	JJ
cord-254895-ym0jsir5	104	7	immunity	immunity	NN
cord-254895-ym0jsir5	104	8	remains	remain	VBZ
cord-254895-ym0jsir5	104	9	unclear	unclear	JJ
cord-254895-ym0jsir5	104	10	so	so	RB
cord-254895-ym0jsir5	104	11	far	far	RB
cord-254895-ym0jsir5	104	12	.	.	.
cord-254895-ym0jsir5	105	1	Most	Most	JJS
cord-254895-ym0jsir5	105	2	studies	study	NNS
cord-254895-ym0jsir5	105	3	did	do	VBD
cord-254895-ym0jsir5	105	4	not	not	RB
cord-254895-ym0jsir5	105	5	find	find	VB
cord-254895-ym0jsir5	105	6	an	an	DT
cord-254895-ym0jsir5	105	7	essential	essential	JJ
cord-254895-ym0jsir5	105	8	role	role	NN
cord-254895-ym0jsir5	105	9	of	of	IN
cord-254895-ym0jsir5	105	10	TLR3	TLR3	NNP
cord-254895-ym0jsir5	105	11	for	for	IN
cord-254895-ym0jsir5	105	12	the	the	DT
cord-254895-ym0jsir5	105	13	generation	generation	NN
cord-254895-ym0jsir5	105	14	of	of	IN
cord-254895-ym0jsir5	105	15	effective	effective	JJ
cord-254895-ym0jsir5	105	16	antiviral	antiviral	JJ
cord-254895-ym0jsir5	105	17	immune	immune	JJ
cord-254895-ym0jsir5	105	18	responses	response	NNS
cord-254895-ym0jsir5	105	19	.	.	.
cord-254895-ym0jsir5	106	1	TLR3-deficient	tlr3-deficient	NN
cord-254895-ym0jsir5	106	2	mice	mouse	NNS
cord-254895-ym0jsir5	106	3	are	be	VBP
cord-254895-ym0jsir5	106	4	as	as	RB
cord-254895-ym0jsir5	106	5	susceptible	susceptible	JJ
cord-254895-ym0jsir5	106	6	to	to	IN
cord-254895-ym0jsir5	106	7	reovirus	reovirus	NNP
cord-254895-ym0jsir5	106	8	,	,	,
cord-254895-ym0jsir5	106	9	VSV	VSV	NNP
cord-254895-ym0jsir5	106	10	and	and	CC
cord-254895-ym0jsir5	106	11	LCMV	LCMV	NNP
cord-254895-ym0jsir5	106	12	infection	infection	NN
cord-254895-ym0jsir5	106	13	as	as	IN
cord-254895-ym0jsir5	106	14	wild	wild	JJ
cord-254895-ym0jsir5	106	15	-	-	HYPH
cord-254895-ym0jsir5	106	16	type	type	NN
cord-254895-ym0jsir5	106	17	mice	mouse	NNS
cord-254895-ym0jsir5	106	18	and	and	CC
cord-254895-ym0jsir5	106	19	there	there	EX
cord-254895-ym0jsir5	106	20	was	be	VBD
cord-254895-ym0jsir5	106	21	no	no	DT
cord-254895-ym0jsir5	106	22	significant	significant	JJ
cord-254895-ym0jsir5	106	23	difference	difference	NN
cord-254895-ym0jsir5	106	24	in	in	IN
cord-254895-ym0jsir5	106	25	generating	generate	VBG
cord-254895-ym0jsir5	106	26	specific	specific	JJ
cord-254895-ym0jsir5	106	27	CD4	CD4	NNP
cord-254895-ym0jsir5	106	28	and	and	CC
cord-254895-ym0jsir5	106	29	CD8	CD8	NNP
cord-254895-ym0jsir5	106	30	T	T	NNP
cord-254895-ym0jsir5	106	31	cell	cell	NN
cord-254895-ym0jsir5	106	32	responses	response	NNS
cord-254895-ym0jsir5	106	33	to	to	IN
cord-254895-ym0jsir5	106	34	these	these	DT
cord-254895-ym0jsir5	106	35	viruses	virus	NNS
cord-254895-ym0jsir5	107	1	(	(	-LRB-
cord-254895-ym0jsir5	107	2	Edelmann	Edelmann	NNP
cord-254895-ym0jsir5	107	3	et	et	NNP
cord-254895-ym0jsir5	107	4	al	al	NNP
cord-254895-ym0jsir5	107	5	.	.	NNP
cord-254895-ym0jsir5	107	6	,	,	,
cord-254895-ym0jsir5	107	7	2004	2004	CD
cord-254895-ym0jsir5	107	8	)	)	-RRB-
cord-254895-ym0jsir5	107	9	.	.	.
cord-254895-ym0jsir5	108	1	Interestingly	interestingly	RB
cord-254895-ym0jsir5	108	2	,	,	,
cord-254895-ym0jsir5	108	3	however	however	RB
cord-254895-ym0jsir5	108	4	,	,	,
cord-254895-ym0jsir5	108	5	virally	virally	RB
cord-254895-ym0jsir5	108	6	induced	induce	VBN
cord-254895-ym0jsir5	108	7	CNS	CNS	NNP
cord-254895-ym0jsir5	108	8	injury	injury	NN
cord-254895-ym0jsir5	108	9	was	be	VBD
cord-254895-ym0jsir5	108	10	improved	improve	VBN
cord-254895-ym0jsir5	108	11	by	by	IN
cord-254895-ym0jsir5	108	12	TLR3-deficiency	TLR3-deficiency	NNP
cord-254895-ym0jsir5	108	13	suggesting	suggest	VBG
cord-254895-ym0jsir5	108	14	that	that	IN
cord-254895-ym0jsir5	108	15	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	108	16	responses	response	NNS
cord-254895-ym0jsir5	108	17	mediated	mediate	VBN
cord-254895-ym0jsir5	108	18	by	by	IN
cord-254895-ym0jsir5	108	19	TLR3	TLR3	NNP
cord-254895-ym0jsir5	108	20	are	be	VBP
cord-254895-ym0jsir5	108	21	at	at	IN
cord-254895-ym0jsir5	108	22	least	least	JJS
cord-254895-ym0jsir5	108	23	partially	partially	RB
cord-254895-ym0jsir5	108	24	responsible	responsible	JJ
cord-254895-ym0jsir5	108	25	for	for	IN
cord-254895-ym0jsir5	108	26	a	a	DT
cord-254895-ym0jsir5	108	27	breakdown	breakdown	NN
cord-254895-ym0jsir5	108	28	of	of	IN
cord-254895-ym0jsir5	108	29	the	the	DT
cord-254895-ym0jsir5	108	30	blood	blood	NN
cord-254895-ym0jsir5	108	31	-	-	HYPH
cord-254895-ym0jsir5	108	32	brain	brain	NN
cord-254895-ym0jsir5	108	33	barrier	barrier	NN
cord-254895-ym0jsir5	108	34	which	which	WDT
cord-254895-ym0jsir5	108	35	facilitates	facilitate	VBZ
cord-254895-ym0jsir5	108	36	and	and	CC
cord-254895-ym0jsir5	108	37	enhances	enhance	VBZ
cord-254895-ym0jsir5	108	38	virus	virus	NN
cord-254895-ym0jsir5	108	39	entry	entry	NN
cord-254895-ym0jsir5	108	40	into	into	IN
cord-254895-ym0jsir5	108	41	the	the	DT
cord-254895-ym0jsir5	108	42	brain	brain	NN
cord-254895-ym0jsir5	108	43	.	.	.
cord-254895-ym0jsir5	109	1	TLR3-deficient	tlr3-deficient	NN
cord-254895-ym0jsir5	109	2	mice	mouse	NNS
cord-254895-ym0jsir5	109	3	survived	survive	VBD
cord-254895-ym0jsir5	109	4	viral	viral	JJ
cord-254895-ym0jsir5	109	5	CNS	CNS	NNP
cord-254895-ym0jsir5	109	6	infection	infection	NN
cord-254895-ym0jsir5	109	7	with	with	IN
cord-254895-ym0jsir5	109	8	West	West	NNP
cord-254895-ym0jsir5	109	9	Nile	Nile	NNP
cord-254895-ym0jsir5	109	10	virus	virus	NN
cord-254895-ym0jsir5	109	11	(	(	-LRB-
cord-254895-ym0jsir5	109	12	Wang	Wang	NNP
cord-254895-ym0jsir5	109	13	et	et	NNP
cord-254895-ym0jsir5	109	14	al	al	NNP
cord-254895-ym0jsir5	109	15	.	.	NNP
cord-254895-ym0jsir5	109	16	,	,	,
cord-254895-ym0jsir5	109	17	2004	2004	CD
cord-254895-ym0jsir5	109	18	)	)	-RRB-
cord-254895-ym0jsir5	109	19	,	,	,
cord-254895-ym0jsir5	109	20	which	which	WDT
cord-254895-ym0jsir5	109	21	is	be	VBZ
cord-254895-ym0jsir5	109	22	characterized	characterize	VBN
cord-254895-ym0jsir5	109	23	by	by	IN
cord-254895-ym0jsir5	109	24	meningitis	meningitis	NN
cord-254895-ym0jsir5	109	25	and	and	CC
cord-254895-ym0jsir5	109	26	encephalitis	encephalitis	NN
cord-254895-ym0jsir5	109	27	induced	induce	VBN
cord-254895-ym0jsir5	109	28	by	by	IN
cord-254895-ym0jsir5	109	29	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	109	30	mediators	mediator	NNS
cord-254895-ym0jsir5	109	31	,	,	,
cord-254895-ym0jsir5	109	32	for	for	IN
cord-254895-ym0jsir5	109	33	longer	long	JJR
cord-254895-ym0jsir5	109	34	time	time	NN
cord-254895-ym0jsir5	109	35	periods	period	NNS
cord-254895-ym0jsir5	109	36	than	than	IN
cord-254895-ym0jsir5	109	37	wild	wild	JJ
cord-254895-ym0jsir5	109	38	-	-	HYPH
cord-254895-ym0jsir5	109	39	type	type	NN
cord-254895-ym0jsir5	109	40	mice	mouse	NNS
cord-254895-ym0jsir5	109	41	.	.	.
cord-254895-ym0jsir5	110	1	Similarly	similarly	RB
cord-254895-ym0jsir5	110	2	,	,	,
cord-254895-ym0jsir5	110	3	in	in	IN
cord-254895-ym0jsir5	111	1	murine	murine	JJ
cord-254895-ym0jsir5	111	2	influenza	influenza	NN
cord-254895-ym0jsir5	111	3	A	a	DT
cord-254895-ym0jsir5	111	4	virus	virus	NN
cord-254895-ym0jsir5	111	5	infection	infection	NN
cord-254895-ym0jsir5	111	6	TLR3-mediated	tlr3-mediate	VBD
cord-254895-ym0jsir5	111	7	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	111	8	responses	response	NNS
cord-254895-ym0jsir5	111	9	in	in	IN
cord-254895-ym0jsir5	111	10	the	the	DT
cord-254895-ym0jsir5	111	11	lung	lung	NN
cord-254895-ym0jsir5	111	12	contribute	contribute	VBP
cord-254895-ym0jsir5	111	13	significantly	significantly	RB
cord-254895-ym0jsir5	111	14	to	to	TO
cord-254895-ym0jsir5	111	15	host	host	VB
cord-254895-ym0jsir5	111	16	morbidity	morbidity	NN
cord-254895-ym0jsir5	111	17	and	and	CC
cord-254895-ym0jsir5	111	18	lethality	lethality	NN
cord-254895-ym0jsir5	111	19	.	.	.
cord-254895-ym0jsir5	112	1	Despite	despite	IN
cord-254895-ym0jsir5	112	2	higher	high	JJR
cord-254895-ym0jsir5	112	3	pulmonary	pulmonary	JJ
cord-254895-ym0jsir5	112	4	viral	viral	JJ
cord-254895-ym0jsir5	112	5	loads	load	NNS
cord-254895-ym0jsir5	112	6	TLR3	TLR3	NNP
cord-254895-ym0jsir5	112	7	À	à	NN
cord-254895-ym0jsir5	112	8	/	/	SYM
cord-254895-ym0jsir5	112	9	À	à	NN
cord-254895-ym0jsir5	112	10	mice	mouse	NNS
cord-254895-ym0jsir5	112	11	showed	show	VBD
cord-254895-ym0jsir5	112	12	less	less	JJR
cord-254895-ym0jsir5	112	13	inflammation	inflammation	NN
cord-254895-ym0jsir5	112	14	and	and	CC
cord-254895-ym0jsir5	112	15	better	well	JJR
cord-254895-ym0jsir5	112	16	survival	survival	NN
cord-254895-ym0jsir5	113	1	(	(	-LRB-
cord-254895-ym0jsir5	113	2	Le	Le	NNP
cord-254895-ym0jsir5	113	3	Goffic	Goffic	NNP
cord-254895-ym0jsir5	113	4	et	et	NNP
cord-254895-ym0jsir5	113	5	al	al	NNP
cord-254895-ym0jsir5	113	6	.	.	NNP
cord-254895-ym0jsir5	113	7	,	,	,
cord-254895-ym0jsir5	113	8	2006	2006	CD
cord-254895-ym0jsir5	113	9	)	)	-RRB-
cord-254895-ym0jsir5	113	10	.	.	.
cord-254895-ym0jsir5	114	1	Interestingly	interestingly	RB
cord-254895-ym0jsir5	114	2	,	,	,
cord-254895-ym0jsir5	114	3	human	human	JJ
cord-254895-ym0jsir5	114	4	lung	lung	NN
cord-254895-ym0jsir5	114	5	epithelial	epithelial	NN
cord-254895-ym0jsir5	114	6	cells	cell	NNS
cord-254895-ym0jsir5	114	7	express	express	VBP
cord-254895-ym0jsir5	114	8	proinflammatory	proinflammatory	JJ
cord-254895-ym0jsir5	114	9	cytokines	cytokine	NNS
cord-254895-ym0jsir5	114	10	including	include	VBG
cord-254895-ym0jsir5	114	11	IL-6	IL-6	NNP
cord-254895-ym0jsir5	114	12	and	and	CC
cord-254895-ym0jsir5	114	13	IL-8	IL-8	NNP
cord-254895-ym0jsir5	114	14	upon	upon	IN
cord-254895-ym0jsir5	114	15	infection	infection	NN
cord-254895-ym0jsir5	114	16	with	with	IN
cord-254895-ym0jsir5	114	17	influenza	influenza	NN
cord-254895-ym0jsir5	114	18	A	a	DT
cord-254895-ym0jsir5	114	19	virus	virus	NN
cord-254895-ym0jsir5	114	20	in	in	IN
cord-254895-ym0jsir5	114	21	a	a	DT
cord-254895-ym0jsir5	114	22	TLR3dependent	tlr3dependent	CD
cord-254895-ym0jsir5	114	23	manner	manner	NN
cord-254895-ym0jsir5	115	1	(	(	-LRB-
cord-254895-ym0jsir5	115	2	Le	Le	NNP
cord-254895-ym0jsir5	115	3	Goffic	Goffic	NNP
cord-254895-ym0jsir5	115	4	et	et	NNP
cord-254895-ym0jsir5	115	5	al	al	NNP
cord-254895-ym0jsir5	115	6	.	.	NNP
cord-254895-ym0jsir5	115	7	,	,	,
cord-254895-ym0jsir5	115	8	2007	2007	CD
cord-254895-ym0jsir5	115	9	)	)	-RRB-
cord-254895-ym0jsir5	115	10	,	,	,
cord-254895-ym0jsir5	115	11	suggesting	suggest	VBG
cord-254895-ym0jsir5	115	12	that	that	IN
cord-254895-ym0jsir5	115	13	TLR3-mediated	tlr3-mediate	VBN
cord-254895-ym0jsir5	115	14	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	115	15	responses	response	NNS
cord-254895-ym0jsir5	115	16	may	may	MD
cord-254895-ym0jsir5	115	17	also	also	RB
cord-254895-ym0jsir5	115	18	contribute	contribute	VB
cord-254895-ym0jsir5	115	19	to	to	IN
cord-254895-ym0jsir5	115	20	influenza	influenza	NN
cord-254895-ym0jsir5	115	21	virus	virus	NN
cord-254895-ym0jsir5	115	22	-	-	HYPH
cord-254895-ym0jsir5	115	23	induced	induce	VBN
cord-254895-ym0jsir5	115	24	lung	lung	NN
cord-254895-ym0jsir5	115	25	pathology	pathology	NN
cord-254895-ym0jsir5	115	26	in	in	IN
cord-254895-ym0jsir5	115	27	humans	human	NNS
cord-254895-ym0jsir5	115	28	.	.	.
cord-254895-ym0jsir5	116	1	The	the	DT
cord-254895-ym0jsir5	116	2	role	role	NN
cord-254895-ym0jsir5	116	3	of	of	IN
cord-254895-ym0jsir5	116	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	116	5	in	in	IN
cord-254895-ym0jsir5	116	6	MCMV	MCMV	NNP
cord-254895-ym0jsir5	116	7	infection	infection	NN
cord-254895-ym0jsir5	116	8	is	be	VBZ
cord-254895-ym0jsir5	116	9	more	more	RBR
cord-254895-ym0jsir5	116	10	controversial	controversial	JJ
cord-254895-ym0jsir5	116	11	.	.	.
cord-254895-ym0jsir5	117	1	Whereas	whereas	IN
cord-254895-ym0jsir5	117	2	Edelmann	Edelmann	NNP
cord-254895-ym0jsir5	117	3	et	et	NNP
cord-254895-ym0jsir5	117	4	al	al	NNP
cord-254895-ym0jsir5	117	5	.	.	.
cord-254895-ym0jsir5	118	1	(	(	-LRB-
cord-254895-ym0jsir5	118	2	2004	2004	CD
cord-254895-ym0jsir5	118	3	)	)	-RRB-
cord-254895-ym0jsir5	118	4	claimed	claim	VBD
cord-254895-ym0jsir5	118	5	no	no	DT
cord-254895-ym0jsir5	118	6	impairment	impairment	NN
cord-254895-ym0jsir5	118	7	in	in	IN
cord-254895-ym0jsir5	118	8	antiviral	antiviral	JJ
cord-254895-ym0jsir5	118	9	response	response	NN
cord-254895-ym0jsir5	118	10	to	to	IN
cord-254895-ym0jsir5	118	11	MCMV	MCMV	NNP
cord-254895-ym0jsir5	118	12	in	in	IN
cord-254895-ym0jsir5	118	13	TLR3	TLR3	NNP
cord-254895-ym0jsir5	118	14	À	à	NN
cord-254895-ym0jsir5	118	15	/	/	SYM
cord-254895-ym0jsir5	118	16	À	à	NN
cord-254895-ym0jsir5	118	17	mice	mouse	NNS
cord-254895-ym0jsir5	118	18	,	,	,
cord-254895-ym0jsir5	118	19	another	another	DT
cord-254895-ym0jsir5	118	20	publication	publication	NN
cord-254895-ym0jsir5	118	21	suggested	suggest	VBD
cord-254895-ym0jsir5	118	22	a	a	DT
cord-254895-ym0jsir5	118	23	higher	high	JJR
cord-254895-ym0jsir5	118	24	susceptibility	susceptibility	NN
cord-254895-ym0jsir5	118	25	to	to	IN
cord-254895-ym0jsir5	118	26	MCMV	MCMV	NNP
cord-254895-ym0jsir5	118	27	in	in	IN
cord-254895-ym0jsir5	118	28	the	the	DT
cord-254895-ym0jsir5	118	29	absence	absence	NN
cord-254895-ym0jsir5	118	30	TLR3	tlr3	XX
cord-254895-ym0jsir5	119	1	(	(	-LRB-
cord-254895-ym0jsir5	119	2	Tabeta	Tabeta	NNP
cord-254895-ym0jsir5	119	3	et	et	FW
cord-254895-ym0jsir5	119	4	al	al	NNP
cord-254895-ym0jsir5	119	5	.	.	NNP
cord-254895-ym0jsir5	119	6	,	,	,
cord-254895-ym0jsir5	119	7	2004	2004	CD
cord-254895-ym0jsir5	119	8	)	)	-RRB-
cord-254895-ym0jsir5	119	9	.	.	.
cord-254895-ym0jsir5	120	1	In	in	IN
cord-254895-ym0jsir5	120	2	this	this	DT
cord-254895-ym0jsir5	120	3	study	study	NN
cord-254895-ym0jsir5	120	4	TLR3	TLR3	NNP
cord-254895-ym0jsir5	120	5	deficiency	deficiency	NN
cord-254895-ym0jsir5	120	6	results	result	NNS
cord-254895-ym0jsir5	120	7	in	in	IN
cord-254895-ym0jsir5	120	8	higher	high	JJR
cord-254895-ym0jsir5	120	9	splenic	splenic	JJ
cord-254895-ym0jsir5	120	10	viral	viral	JJ
cord-254895-ym0jsir5	120	11	titers	titer	NNS
cord-254895-ym0jsir5	120	12	compared	compare	VBN
cord-254895-ym0jsir5	120	13	to	to	IN
cord-254895-ym0jsir5	120	14	wild	wild	JJ
cord-254895-ym0jsir5	120	15	-	-	HYPH
cord-254895-ym0jsir5	120	16	type	type	NN
cord-254895-ym0jsir5	120	17	mice	mouse	NNS
cord-254895-ym0jsir5	120	18	.	.	.
cord-254895-ym0jsir5	121	1	Similar	similar	JJ
cord-254895-ym0jsir5	121	2	observations	observation	NNS
cord-254895-ym0jsir5	121	3	were	be	VBD
cord-254895-ym0jsir5	121	4	made	make	VBN
cord-254895-ym0jsir5	121	5	when	when	WRB
cord-254895-ym0jsir5	121	6	infecting	infect	VBG
cord-254895-ym0jsir5	121	7	TRIF	TRIF	NNP
cord-254895-ym0jsir5	121	8	Lps2	Lps2	NNP
cord-254895-ym0jsir5	121	9	/	/	SYM
cord-254895-ym0jsir5	121	10	Lps2	Lps2	NNP
cord-254895-ym0jsir5	121	11	mice	mouse	NNS
cord-254895-ym0jsir5	121	12	with	with	IN
cord-254895-ym0jsir5	121	13	MCMV	MCMV	NNP
cord-254895-ym0jsir5	121	14	(	(	-LRB-
cord-254895-ym0jsir5	121	15	Hoebe	Hoebe	NNP
cord-254895-ym0jsir5	121	16	et	et	FW
cord-254895-ym0jsir5	121	17	al	al	NNP
cord-254895-ym0jsir5	121	18	.	.	NNP
cord-254895-ym0jsir5	121	19	,	,	,
cord-254895-ym0jsir5	121	20	2003	2003	CD
cord-254895-ym0jsir5	121	21	)	)	-RRB-
cord-254895-ym0jsir5	121	22	.	.	.
cord-254895-ym0jsir5	122	1	The	the	DT
cord-254895-ym0jsir5	122	2	increased	increase	VBN
cord-254895-ym0jsir5	122	3	viral	viral	JJ
cord-254895-ym0jsir5	122	4	load	load	NN
cord-254895-ym0jsir5	122	5	was	be	VBD
cord-254895-ym0jsir5	122	6	accompanied	accompany	VBN
cord-254895-ym0jsir5	122	7	by	by	IN
cord-254895-ym0jsir5	122	8	a	a	DT
cord-254895-ym0jsir5	122	9	decreased	decrease	VBN
cord-254895-ym0jsir5	122	10	cytokine	cytokine	NN
cord-254895-ym0jsir5	122	11	response	response	NN
cord-254895-ym0jsir5	122	12	which	which	WDT
cord-254895-ym0jsir5	122	13	mostly	mostly	RB
cord-254895-ym0jsir5	122	14	affected	affect	VBN
cord-254895-ym0jsir5	122	15	type	type	NN
cord-254895-ym0jsir5	123	1	I	-PRON-	PRP
cord-254895-ym0jsir5	123	2	IFN	IFN	NNP
cord-254895-ym0jsir5	123	3	and	and	CC
cord-254895-ym0jsir5	123	4	to	to	IN
cord-254895-ym0jsir5	123	5	a	a	DT
cord-254895-ym0jsir5	123	6	lesser	less	JJR
cord-254895-ym0jsir5	123	7	extent	extent	NN
cord-254895-ym0jsir5	124	1	IL12p40	IL12p40	NNP
cord-254895-ym0jsir5	124	2	and	and	CC
cord-254895-ym0jsir5	124	3	IFN	IFN	NNP
cord-254895-ym0jsir5	124	4	-	-	HYPH
cord-254895-ym0jsir5	124	5	g	g	NNP
cord-254895-ym0jsir5	124	6	produced	produce	VBN
cord-254895-ym0jsir5	124	7	by	by	IN
cord-254895-ym0jsir5	124	8	NK	NK	NNP
cord-254895-ym0jsir5	124	9	and	and	CC
cord-254895-ym0jsir5	124	10	NKT	NKT	NNP
cord-254895-ym0jsir5	124	11	cells	cell	NNS
cord-254895-ym0jsir5	125	1	(	(	-LRB-
cord-254895-ym0jsir5	125	2	Tabeta	Tabeta	NNP
cord-254895-ym0jsir5	125	3	et	et	FW
cord-254895-ym0jsir5	125	4	al	al	NNP
cord-254895-ym0jsir5	125	5	.	.	.
cord-254895-ym0jsir5	126	1	,	,	,
cord-254895-ym0jsir5	126	2	2004	2004	CD
cord-254895-ym0jsir5	126	3	)	)	-RRB-
cord-254895-ym0jsir5	126	4	.	.	.
cord-254895-ym0jsir5	127	1	Crosspriming	crosspriming	NN
cord-254895-ym0jsir5	127	2	occurs	occur	VBZ
cord-254895-ym0jsir5	127	3	most	most	RBS
cord-254895-ym0jsir5	127	4	efficiently	efficiently	RB
cord-254895-ym0jsir5	127	5	in	in	IN
cord-254895-ym0jsir5	127	6	the	the	DT
cord-254895-ym0jsir5	127	7	specialized	specialized	JJ
cord-254895-ym0jsir5	127	8	subpopulation	subpopulation	NN
cord-254895-ym0jsir5	127	9	of	of	IN
cord-254895-ym0jsir5	127	10	CD8a	CD8a	NNP
cord-254895-ym0jsir5	127	11	+	+	CC
cord-254895-ym0jsir5	127	12	DCs	DCs	NNP
cord-254895-ym0jsir5	127	13	,	,	,
cord-254895-ym0jsir5	127	14	which	which	WDT
cord-254895-ym0jsir5	127	15	have	have	VBP
cord-254895-ym0jsir5	127	16	a	a	DT
cord-254895-ym0jsir5	127	17	high	high	JJ
cord-254895-ym0jsir5	127	18	capacity	capacity	NN
cord-254895-ym0jsir5	127	19	for	for	IN
cord-254895-ym0jsir5	127	20	internalization	internalization	NN
cord-254895-ym0jsir5	127	21	of	of	IN
cord-254895-ym0jsir5	127	22	apoptotic	apoptotic	JJ
cord-254895-ym0jsir5	127	23	cells	cell	NNS
cord-254895-ym0jsir5	127	24	.	.	.
cord-254895-ym0jsir5	128	1	TLR3	TLR3	NNP
cord-254895-ym0jsir5	128	2	which	which	WDT
cord-254895-ym0jsir5	128	3	is	be	VBZ
cord-254895-ym0jsir5	128	4	expressed	express	VBN
cord-254895-ym0jsir5	128	5	at	at	IN
cord-254895-ym0jsir5	128	6	high	high	JJ
cord-254895-ym0jsir5	128	7	levels	level	NNS
cord-254895-ym0jsir5	128	8	in	in	IN
cord-254895-ym0jsir5	128	9	CD8a	CD8a	NNP
cord-254895-ym0jsir5	128	10	+	+	CC
cord-254895-ym0jsir5	128	11	DCs	DCs	NNP
cord-254895-ym0jsir5	128	12	(	(	-LRB-
cord-254895-ym0jsir5	128	13	Edwards	Edwards	NNP
cord-254895-ym0jsir5	128	14	et	et	NNP
cord-254895-ym0jsir5	128	15	al	al	NNP
cord-254895-ym0jsir5	128	16	.	.	NNP
cord-254895-ym0jsir5	128	17	,	,	,
cord-254895-ym0jsir5	128	18	2003	2003	CD
cord-254895-ym0jsir5	128	19	)	)	-RRB-
cord-254895-ym0jsir5	128	20	plays	play	VBZ
cord-254895-ym0jsir5	128	21	a	a	DT
cord-254895-ym0jsir5	128	22	critical	critical	JJ
cord-254895-ym0jsir5	128	23	role	role	NN
cord-254895-ym0jsir5	128	24	for	for	IN
cord-254895-ym0jsir5	128	25	crosspriming	crosspriming	NN
cord-254895-ym0jsir5	128	26	of	of	IN
cord-254895-ym0jsir5	128	27	CTLs	ctl	NNS
cord-254895-ym0jsir5	128	28	directed	direct	VBN
cord-254895-ym0jsir5	128	29	against	against	IN
cord-254895-ym0jsir5	128	30	viruses	virus	NNS
cord-254895-ym0jsir5	128	31	that	that	WDT
cord-254895-ym0jsir5	128	32	do	do	VBP
cord-254895-ym0jsir5	128	33	not	not	RB
cord-254895-ym0jsir5	128	34	infect	infect	VB
cord-254895-ym0jsir5	128	35	DCs	DCs	NNP
cord-254895-ym0jsir5	128	36	directly	directly	RB
cord-254895-ym0jsir5	128	37	.	.	.
cord-254895-ym0jsir5	129	1	CD8a	CD8a	NNP
cord-254895-ym0jsir5	129	2	+	+	CC
cord-254895-ym0jsir5	129	3	DCs	dc	NNS
cord-254895-ym0jsir5	129	4	are	be	VBP
cord-254895-ym0jsir5	129	5	activated	activate	VBN
cord-254895-ym0jsir5	129	6	by	by	IN
cord-254895-ym0jsir5	129	7	viral	viral	JJ
cord-254895-ym0jsir5	129	8	RNA	RNA	NNP
cord-254895-ym0jsir5	129	9	contained	contain	VBN
cord-254895-ym0jsir5	129	10	in	in	IN
cord-254895-ym0jsir5	129	11	internalized	internalize	VBN
cord-254895-ym0jsir5	129	12	virally	virally	RB
cord-254895-ym0jsir5	129	13	infected	infect	VBN
cord-254895-ym0jsir5	129	14	apoptotic	apoptotic	JJ
cord-254895-ym0jsir5	129	15	cells	cell	NNS
cord-254895-ym0jsir5	129	16	and	and	CC
cord-254895-ym0jsir5	129	17	crosspresent	crosspresent	NN
cord-254895-ym0jsir5	129	18	viral	viral	JJ
cord-254895-ym0jsir5	129	19	antigens	antigen	NNS
cord-254895-ym0jsir5	129	20	to	to	IN
cord-254895-ym0jsir5	129	21	specific	specific	JJ
cord-254895-ym0jsir5	129	22	CD8	CD8	NNP
cord-254895-ym0jsir5	129	23	+	+	CC
cord-254895-ym0jsir5	129	24	T	t	NN
cord-254895-ym0jsir5	129	25	cells	cell	NNS
cord-254895-ym0jsir5	129	26	in	in	IN
cord-254895-ym0jsir5	129	27	a	a	DT
cord-254895-ym0jsir5	129	28	TLR3-dependent	tlr3-dependent	NN
cord-254895-ym0jsir5	129	29	manner	manner	NN
cord-254895-ym0jsir5	129	30	(	(	-LRB-
cord-254895-ym0jsir5	129	31	Schulz	Schulz	NNP
cord-254895-ym0jsir5	129	32	et	et	NNP
cord-254895-ym0jsir5	129	33	al	al	NNP
cord-254895-ym0jsir5	129	34	.	.	NNP
cord-254895-ym0jsir5	129	35	,	,	,
cord-254895-ym0jsir5	129	36	2005	2005	CD
cord-254895-ym0jsir5	129	37	)	)	-RRB-
cord-254895-ym0jsir5	129	38	.	.	.
cord-254895-ym0jsir5	130	1	Toll	toll	NN
cord-254895-ym0jsir5	130	2	-	-	HYPH
cord-254895-ym0jsir5	130	3	like	like	JJ
cord-254895-ym0jsir5	130	4	receptor	receptor	NN
cord-254895-ym0jsir5	130	5	9	9	CD
cord-254895-ym0jsir5	130	6	TLR9	TLR9	NNP
cord-254895-ym0jsir5	130	7	has	have	VBZ
cord-254895-ym0jsir5	130	8	been	be	VBN
cord-254895-ym0jsir5	130	9	described	describe	VBN
cord-254895-ym0jsir5	130	10	to	to	TO
cord-254895-ym0jsir5	130	11	recognize	recognize	VB
cord-254895-ym0jsir5	130	12	bacterial	bacterial	JJ
cord-254895-ym0jsir5	130	13	DNA	dna	NN
cord-254895-ym0jsir5	130	14	or	or	CC
cord-254895-ym0jsir5	130	15	synthetic	synthetic	JJ
cord-254895-ym0jsir5	130	16	oligodesoxyribonucleotides	oligodesoxyribonucleotide	NNS
cord-254895-ym0jsir5	131	1	(	(	-LRB-
cord-254895-ym0jsir5	131	2	ODN	ODN	NNP
cord-254895-ym0jsir5	131	3	)	)	-RRB-
cord-254895-ym0jsir5	131	4	containing	contain	VBG
cord-254895-ym0jsir5	131	5	specific	specific	JJ
cord-254895-ym0jsir5	131	6	unmethylated	unmethylate	VBN
cord-254895-ym0jsir5	131	7	CpG	CpG	NNP
cord-254895-ym0jsir5	131	8	sequence	sequence	NN
cord-254895-ym0jsir5	131	9	motifs	motifs	NNP
cord-254895-ym0jsir5	131	10	.	.	.
cord-254895-ym0jsir5	132	1	These	these	DT
cord-254895-ym0jsir5	132	2	can	can	MD
cord-254895-ym0jsir5	132	3	also	also	RB
cord-254895-ym0jsir5	132	4	be	be	VB
cord-254895-ym0jsir5	132	5	found	find	VBN
cord-254895-ym0jsir5	132	6	in	in	IN
cord-254895-ym0jsir5	132	7	the	the	DT
cord-254895-ym0jsir5	132	8	genome	genome	NN
cord-254895-ym0jsir5	132	9	of	of	IN
cord-254895-ym0jsir5	132	10	DNA	dna	NN
cord-254895-ym0jsir5	132	11	viruses	virus	NNS
cord-254895-ym0jsir5	132	12	.	.	.
cord-254895-ym0jsir5	133	1	Viruses	virus	NNS
cord-254895-ym0jsir5	133	2	recognized	recognize	VBN
cord-254895-ym0jsir5	133	3	by	by	IN
cord-254895-ym0jsir5	133	4	TLR9	TLR9	NNP
cord-254895-ym0jsir5	133	5	are	be	VBP
cord-254895-ym0jsir5	133	6	HSV	HSV	NNP
cord-254895-ym0jsir5	133	7	type	type	NN
cord-254895-ym0jsir5	133	8	1	1	CD
cord-254895-ym0jsir5	133	9	and	and	CC
cord-254895-ym0jsir5	133	10	2	2	CD
cord-254895-ym0jsir5	134	1	Krug	Krug	NNP
cord-254895-ym0jsir5	134	2	et	et	NNP
cord-254895-ym0jsir5	134	3	al	al	NNP
cord-254895-ym0jsir5	134	4	.	.	NNP
cord-254895-ym0jsir5	134	5	,	,	,
cord-254895-ym0jsir5	134	6	2004b	2004b	CD
cord-254895-ym0jsir5	134	7	)	)	-RRB-
cord-254895-ym0jsir5	135	1	,	,	,
cord-254895-ym0jsir5	135	2	MCMV	MCMV	NNP
cord-254895-ym0jsir5	135	3	(	(	-LRB-
cord-254895-ym0jsir5	135	4	Krug	Krug	NNP
cord-254895-ym0jsir5	135	5	et	et	NNP
cord-254895-ym0jsir5	135	6	al	al	NNP
cord-254895-ym0jsir5	135	7	.	.	NNP
cord-254895-ym0jsir5	135	8	,	,	,
cord-254895-ym0jsir5	135	9	2004a	2004a	CD
cord-254895-ym0jsir5	135	10	;	;	:
cord-254895-ym0jsir5	135	11	Lund	Lund	NNP
cord-254895-ym0jsir5	135	12	et	et	NNP
cord-254895-ym0jsir5	135	13	al	al	NNP
cord-254895-ym0jsir5	135	14	.	.	NNP
cord-254895-ym0jsir5	135	15	,	,	,
cord-254895-ym0jsir5	135	16	2003	2003	CD
cord-254895-ym0jsir5	135	17	;	;	:
cord-254895-ym0jsir5	136	1	Tabeta	Tabeta	NNP
cord-254895-ym0jsir5	136	2	et	et	FW
cord-254895-ym0jsir5	136	3	al	al	NNP
cord-254895-ym0jsir5	136	4	.	.	NNP
cord-254895-ym0jsir5	136	5	,	,	,
cord-254895-ym0jsir5	136	6	2004	2004	CD
cord-254895-ym0jsir5	136	7	)	)	-RRB-
cord-254895-ym0jsir5	136	8	,	,	,
cord-254895-ym0jsir5	136	9	adenovirus	adenovirus	NN
cord-254895-ym0jsir5	136	10	(	(	-LRB-
cord-254895-ym0jsir5	136	11	Basner	Basner	NNP
cord-254895-ym0jsir5	136	12	-	-	HYPH
cord-254895-ym0jsir5	136	13	Tschakarjan	Tschakarjan	NNP
cord-254895-ym0jsir5	136	14	et	et	NNP
cord-254895-ym0jsir5	136	15	al	al	NNP
cord-254895-ym0jsir5	136	16	.	.	NNP
cord-254895-ym0jsir5	136	17	,	,	,
cord-254895-ym0jsir5	136	18	2006	2006	CD
cord-254895-ym0jsir5	136	19	)	)	-RRB-
cord-254895-ym0jsir5	136	20	and	and	CC
cord-254895-ym0jsir5	136	21	baculovirus	baculovirus	NNP
cord-254895-ym0jsir5	136	22	(	(	-LRB-
cord-254895-ym0jsir5	136	23	Abe	Abe	NNP
cord-254895-ym0jsir5	136	24	et	et	NNP
cord-254895-ym0jsir5	136	25	al	al	NNP
cord-254895-ym0jsir5	136	26	.	.	NNP
cord-254895-ym0jsir5	136	27	,	,	,
cord-254895-ym0jsir5	136	28	2005	2005	CD
cord-254895-ym0jsir5	136	29	)	)	-RRB-
cord-254895-ym0jsir5	136	30	.	.	.
cord-254895-ym0jsir5	137	1	Recognition	recognition	NN
cord-254895-ym0jsir5	137	2	of	of	IN
cord-254895-ym0jsir5	137	3	HSV	HSV	NNP
cord-254895-ym0jsir5	137	4	or	or	CC
cord-254895-ym0jsir5	137	5	MCMV	MCMV	NNP
cord-254895-ym0jsir5	137	6	by	by	IN
cord-254895-ym0jsir5	137	7	TLR9	TLR9	NNP
cord-254895-ym0jsir5	137	8	of	of	IN
cord-254895-ym0jsir5	137	9	pDCs	pDCs	NNP
cord-254895-ym0jsir5	137	10	results	result	NNS
cord-254895-ym0jsir5	137	11	in	in	IN
cord-254895-ym0jsir5	137	12	robust	robust	JJ
cord-254895-ym0jsir5	137	13	induction	induction	NN
cord-254895-ym0jsir5	137	14	of	of	IN
cord-254895-ym0jsir5	137	15	type	type	NN
cord-254895-ym0jsir5	138	1	I	-PRON-	PRP
cord-254895-ym0jsir5	138	2	interferon	interferon	VBD
cord-254895-ym0jsir5	138	3	and	and	CC
cord-254895-ym0jsir5	138	4	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	138	5	cytokines	cytokine	NNS
cord-254895-ym0jsir5	139	1	(	(	-LRB-
cord-254895-ym0jsir5	139	2	Krug	Krug	NNP
cord-254895-ym0jsir5	139	3	et	et	NNP
cord-254895-ym0jsir5	139	4	al	al	NNP
cord-254895-ym0jsir5	139	5	.	.	NNP
cord-254895-ym0jsir5	139	6	,	,	,
cord-254895-ym0jsir5	139	7	2004a	2004a	CD
cord-254895-ym0jsir5	139	8	,	,	,
cord-254895-ym0jsir5	139	9	b	b	LS
cord-254895-ym0jsir5	139	10	;	;	:
cord-254895-ym0jsir5	139	11	Lund	Lund	NNP
cord-254895-ym0jsir5	139	12	et	et	NNP
cord-254895-ym0jsir5	139	13	al	al	NNP
cord-254895-ym0jsir5	139	14	.	.	NNP
cord-254895-ym0jsir5	139	15	,	,	,
cord-254895-ym0jsir5	139	16	2003	2003	CD
cord-254895-ym0jsir5	139	17	)	)	-RRB-
cord-254895-ym0jsir5	139	18	.	.	.
cord-254895-ym0jsir5	140	1	CpG	CpG	NNP
cord-254895-ym0jsir5	140	2	ODN	ODN	NNP
cord-254895-ym0jsir5	140	3	class	class	NN
cord-254895-ym0jsir5	140	4	A	A	NNP
cord-254895-ym0jsir5	140	5	,	,	,
cord-254895-ym0jsir5	140	6	B	B	NNP
cord-254895-ym0jsir5	140	7	and	and	CC
cord-254895-ym0jsir5	140	8	C	C	NNP
cord-254895-ym0jsir5	140	9	have	have	VBP
cord-254895-ym0jsir5	140	10	been	be	VBN
cord-254895-ym0jsir5	140	11	designed	design	VBN
cord-254895-ym0jsir5	140	12	to	to	TO
cord-254895-ym0jsir5	140	13	trigger	trigger	VB
cord-254895-ym0jsir5	140	14	primarily	primarily	RB
cord-254895-ym0jsir5	140	15	type	type	NN
cord-254895-ym0jsir5	141	1	I	-PRON-	PRP
cord-254895-ym0jsir5	141	2	IFN	IFN	NNP
cord-254895-ym0jsir5	141	3	response	response	NN
cord-254895-ym0jsir5	141	4	(	(	-LRB-
cord-254895-ym0jsir5	141	5	A	a	NN
cord-254895-ym0jsir5	141	6	)	)	-RRB-
cord-254895-ym0jsir5	141	7	or	or	CC
cord-254895-ym0jsir5	141	8	costimulatory	costimulatory	NNP
cord-254895-ym0jsir5	141	9	molecule	molecule	NN
cord-254895-ym0jsir5	141	10	expression	expression	NN
cord-254895-ym0jsir5	141	11	and	and	CC
cord-254895-ym0jsir5	141	12	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	141	13	cytokine	cytokine	NN
cord-254895-ym0jsir5	141	14	production	production	NN
cord-254895-ym0jsir5	141	15	(	(	-LRB-
cord-254895-ym0jsir5	141	16	B	b	NN
cord-254895-ym0jsir5	141	17	)	)	-RRB-
cord-254895-ym0jsir5	141	18	or	or	CC
cord-254895-ym0jsir5	141	19	both	both	DT
cord-254895-ym0jsir5	141	20	(	(	-LRB-
cord-254895-ym0jsir5	141	21	C	C	NNP
cord-254895-ym0jsir5	141	22	)	)	-RRB-
cord-254895-ym0jsir5	141	23	in	in	IN
cord-254895-ym0jsir5	141	24	pDCs	pDCs	NNP
cord-254895-ym0jsir5	141	25	.	.	.
cord-254895-ym0jsir5	142	1	CpG	CpG	NNP
cord-254895-ym0jsir5	142	2	-	-	HYPH
cord-254895-ym0jsir5	142	3	B	B	NNP
cord-254895-ym0jsir5	142	4	and	and	CC
cord-254895-ym0jsir5	142	5	CpG	CpG	NNP
cord-254895-ym0jsir5	142	6	-	-	HYPH
cord-254895-ym0jsir5	142	7	C	C	NNP
cord-254895-ym0jsir5	142	8	additionally	additionally	RB
cord-254895-ym0jsir5	142	9	trigger	trigger	VBP
cord-254895-ym0jsir5	142	10	B	b	NN
cord-254895-ym0jsir5	142	11	cell	cell	NN
cord-254895-ym0jsir5	142	12	stimulation	stimulation	NN
cord-254895-ym0jsir5	142	13	via	via	IN
cord-254895-ym0jsir5	142	14	TLR9	TLR9	NNP
cord-254895-ym0jsir5	142	15	(	(	-LRB-
cord-254895-ym0jsir5	142	16	Krug	Krug	NNP
cord-254895-ym0jsir5	142	17	et	et	NNP
cord-254895-ym0jsir5	142	18	al	al	NNP
cord-254895-ym0jsir5	142	19	.	.	.
cord-254895-ym0jsir5	143	1	,	,	,
cord-254895-ym0jsir5	143	2	2001	2001	CD
cord-254895-ym0jsir5	143	3	;	;	:
cord-254895-ym0jsir5	143	4	Verthelyi	Verthelyi	NNP
cord-254895-ym0jsir5	143	5	et	et	NNP
cord-254895-ym0jsir5	143	6	al	al	NNP
cord-254895-ym0jsir5	143	7	.	.	NNP
cord-254895-ym0jsir5	143	8	,	,	,
cord-254895-ym0jsir5	143	9	2001	2001	CD
cord-254895-ym0jsir5	144	1	;	;	:
cord-254895-ym0jsir5	144	2	Hartmann	Hartmann	NNP
cord-254895-ym0jsir5	144	3	et	et	NNP
cord-254895-ym0jsir5	144	4	al	al	NNP
cord-254895-ym0jsir5	144	5	.	.	NNP
cord-254895-ym0jsir5	144	6	,	,	,
cord-254895-ym0jsir5	144	7	2003	2003	CD
cord-254895-ym0jsir5	144	8	)	)	-RRB-
cord-254895-ym0jsir5	144	9	.	.	.
cord-254895-ym0jsir5	145	1	Induction	induction	NN
cord-254895-ym0jsir5	145	2	of	of	IN
cord-254895-ym0jsir5	145	3	type	type	NN
cord-254895-ym0jsir5	146	1	I	-PRON-	PRP
cord-254895-ym0jsir5	146	2	IFNs	ifns	VBP
cord-254895-ym0jsir5	146	3	by	by	IN
cord-254895-ym0jsir5	146	4	TLR9	TLR9	NNP
cord-254895-ym0jsir5	146	5	ligands	ligand	NNS
cord-254895-ym0jsir5	146	6	in	in	IN
cord-254895-ym0jsir5	146	7	pDCs	pDCs	NNP
cord-254895-ym0jsir5	146	8	depends	depend	VBZ
cord-254895-ym0jsir5	146	9	on	on	IN
cord-254895-ym0jsir5	146	10	retention	retention	NN
cord-254895-ym0jsir5	146	11	of	of	IN
cord-254895-ym0jsir5	146	12	the	the	DT
cord-254895-ym0jsir5	146	13	ligand	ligand	NN
cord-254895-ym0jsir5	146	14	-	-	HYPH
cord-254895-ym0jsir5	146	15	receptor	receptor	NN
cord-254895-ym0jsir5	146	16	complex	complex	NN
cord-254895-ym0jsir5	146	17	within	within	IN
cord-254895-ym0jsir5	146	18	early	early	JJ
cord-254895-ym0jsir5	146	19	endosomes	endosome	NNS
cord-254895-ym0jsir5	146	20	at	at	IN
cord-254895-ym0jsir5	146	21	a	a	DT
cord-254895-ym0jsir5	146	22	pH	ph	NN
cord-254895-ym0jsir5	146	23	value	value	NN
cord-254895-ym0jsir5	146	24	between	between	IN
cord-254895-ym0jsir5	146	25	6.2	6.2	CD
cord-254895-ym0jsir5	146	26	and	and	CC
cord-254895-ym0jsir5	146	27	5.5	5.5	CD
cord-254895-ym0jsir5	147	1	(	(	-LRB-
cord-254895-ym0jsir5	147	2	Guiducci	Guiducci	NNP
cord-254895-ym0jsir5	147	3	et	et	NNP
cord-254895-ym0jsir5	147	4	al	al	NNP
cord-254895-ym0jsir5	147	5	.	.	NNP
cord-254895-ym0jsir5	147	6	,	,	,
cord-254895-ym0jsir5	147	7	2006	2006	CD
cord-254895-ym0jsir5	147	8	)	)	-RRB-
cord-254895-ym0jsir5	147	9	.	.	.
cord-254895-ym0jsir5	148	1	Delivery	delivery	NN
cord-254895-ym0jsir5	148	2	of	of	IN
cord-254895-ym0jsir5	148	3	TLR9	tlr9	JJ
cord-254895-ym0jsir5	148	4	ligands	ligand	NNS
cord-254895-ym0jsir5	148	5	to	to	IN
cord-254895-ym0jsir5	148	6	late	late	JJ
cord-254895-ym0jsir5	148	7	endosome	endosome	NN
cord-254895-ym0jsir5	148	8	with	with	IN
cord-254895-ym0jsir5	148	9	lower	low	JJR
cord-254895-ym0jsir5	148	10	pH	pH	NNP
cord-254895-ym0jsir5	148	11	values	value	NNS
cord-254895-ym0jsir5	148	12	(	(	-LRB-
cord-254895-ym0jsir5	148	13	o4.5	o4.5	JJ
cord-254895-ym0jsir5	148	14	)	)	-RRB-
cord-254895-ym0jsir5	148	15	impairs	impair	VBZ
cord-254895-ym0jsir5	148	16	the	the	DT
cord-254895-ym0jsir5	148	17	induction	induction	NN
cord-254895-ym0jsir5	148	18	of	of	IN
cord-254895-ym0jsir5	148	19	type	type	NN
cord-254895-ym0jsir5	148	20	I	-PRON-	PRP
cord-254895-ym0jsir5	148	21	IFNs	ifns	VBP
cord-254895-ym0jsir5	148	22	and	and	CC
cord-254895-ym0jsir5	148	23	promotes	promote	VBZ
cord-254895-ym0jsir5	148	24	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	148	25	cytokine	cytokine	NN
cord-254895-ym0jsir5	148	26	and	and	CC
cord-254895-ym0jsir5	148	27	costimulatory	costimulatory	NNP
cord-254895-ym0jsir5	148	28	molecule	molecule	NN
cord-254895-ym0jsir5	148	29	expression	expression	NN
cord-254895-ym0jsir5	148	30	in	in	IN
cord-254895-ym0jsir5	148	31	pDCs	pDCs	NNP
cord-254895-ym0jsir5	149	1	(	(	-LRB-
cord-254895-ym0jsir5	149	2	Guiducci	Guiducci	NNP
cord-254895-ym0jsir5	149	3	et	et	NNP
cord-254895-ym0jsir5	149	4	al	al	NNP
cord-254895-ym0jsir5	149	5	.	.	NNP
cord-254895-ym0jsir5	149	6	,	,	,
cord-254895-ym0jsir5	149	7	2006	2006	CD
cord-254895-ym0jsir5	149	8	)	)	-RRB-
cord-254895-ym0jsir5	149	9	.	.	.
cord-254895-ym0jsir5	150	1	Early	early	RB
cord-254895-ym0jsir5	150	2	endosomal	endosomal	JJ
cord-254895-ym0jsir5	150	3	retention	retention	NN
cord-254895-ym0jsir5	150	4	is	be	VBZ
cord-254895-ym0jsir5	150	5	achieved	achieve	VBN
cord-254895-ym0jsir5	150	6	by	by	IN
cord-254895-ym0jsir5	150	7	using	use	VBG
cord-254895-ym0jsir5	150	8	CpG	CpG	NNP
cord-254895-ym0jsir5	150	9	-	-	HYPH
cord-254895-ym0jsir5	150	10	A	A	NNP
cord-254895-ym0jsir5	150	11	,	,	,
cord-254895-ym0jsir5	150	12	which	which	WDT
cord-254895-ym0jsir5	150	13	forms	form	VBZ
cord-254895-ym0jsir5	150	14	aggregates	aggregate	NNS
cord-254895-ym0jsir5	150	15	or	or	CC
cord-254895-ym0jsir5	150	16	by	by	IN
cord-254895-ym0jsir5	150	17	transfecting	transfecting	NNP
cord-254895-ym0jsir5	150	18	CpG	CpG	NNP
cord-254895-ym0jsir5	150	19	-	-	HYPH
cord-254895-ym0jsir5	150	20	B	B	NNP
cord-254895-ym0jsir5	150	21	with	with	IN
cord-254895-ym0jsir5	150	22	cationic	cationic	JJ
cord-254895-ym0jsir5	150	23	liposomes	liposome	NNS
cord-254895-ym0jsir5	150	24	or	or	CC
cord-254895-ym0jsir5	150	25	delivering	deliver	VBG
cord-254895-ym0jsir5	150	26	CpG	CpG	NNP
cord-254895-ym0jsir5	150	27	DNA	DNA	NNP
cord-254895-ym0jsir5	150	28	in	in	IN
cord-254895-ym0jsir5	150	29	the	the	DT
cord-254895-ym0jsir5	150	30	form	form	NN
cord-254895-ym0jsir5	150	31	of	of	IN
cord-254895-ym0jsir5	150	32	immune	immune	JJ
cord-254895-ym0jsir5	150	33	complexes	complex	NNS
cord-254895-ym0jsir5	151	1	(	(	-LRB-
cord-254895-ym0jsir5	151	2	Kerkmann	Kerkmann	NNP
cord-254895-ym0jsir5	151	3	et	et	NNP
cord-254895-ym0jsir5	151	4	al	al	NNP
cord-254895-ym0jsir5	151	5	.	.	NNP
cord-254895-ym0jsir5	151	6	,	,	,
cord-254895-ym0jsir5	151	7	2005	2005	CD
cord-254895-ym0jsir5	151	8	;	;	:
cord-254895-ym0jsir5	151	9	Means	Means	NNPS
cord-254895-ym0jsir5	151	10	et	et	NNP
cord-254895-ym0jsir5	151	11	al	al	NNP
cord-254895-ym0jsir5	151	12	.	.	NNP
cord-254895-ym0jsir5	151	13	,	,	,
cord-254895-ym0jsir5	151	14	2005	2005	CD
cord-254895-ym0jsir5	151	15	;	;	:
cord-254895-ym0jsir5	152	1	Guiducci	Guiducci	NNP
cord-254895-ym0jsir5	152	2	et	et	NNP
cord-254895-ym0jsir5	152	3	al	al	NNP
cord-254895-ym0jsir5	152	4	.	.	NNP
cord-254895-ym0jsir5	152	5	,	,	,
cord-254895-ym0jsir5	152	6	2006	2006	CD
cord-254895-ym0jsir5	152	7	)	)	-RRB-
cord-254895-ym0jsir5	152	8	.	.	.
cord-254895-ym0jsir5	153	1	TLR9	tlr9	JJ
cord-254895-ym0jsir5	153	2	ligands	ligand	NNS
cord-254895-ym0jsir5	153	3	delivered	deliver	VBN
cord-254895-ym0jsir5	153	4	within	within	IN
cord-254895-ym0jsir5	153	5	herpes	herpes	NNP
cord-254895-ym0jsir5	153	6	virus	virus	NN
cord-254895-ym0jsir5	153	7	particles	particle	NNS
cord-254895-ym0jsir5	153	8	also	also	RB
cord-254895-ym0jsir5	153	9	seem	seem	VBP
cord-254895-ym0jsir5	153	10	to	to	TO
cord-254895-ym0jsir5	153	11	be	be	VB
cord-254895-ym0jsir5	153	12	retained	retain	VBN
cord-254895-ym0jsir5	153	13	long	long	RB
cord-254895-ym0jsir5	153	14	enough	enough	RB
cord-254895-ym0jsir5	153	15	in	in	IN
cord-254895-ym0jsir5	153	16	the	the	DT
cord-254895-ym0jsir5	153	17	early	early	JJ
cord-254895-ym0jsir5	153	18	endosomal	endosomal	NNP
cord-254895-ym0jsir5	153	19	compartment	compartment	NN
cord-254895-ym0jsir5	153	20	to	to	TO
cord-254895-ym0jsir5	153	21	trigger	trigger	VB
cord-254895-ym0jsir5	153	22	type	type	NN
cord-254895-ym0jsir5	153	23	I	-PRON-	PRP
cord-254895-ym0jsir5	153	24	IFN	IFN	NNP
cord-254895-ym0jsir5	153	25	responses	response	NNS
cord-254895-ym0jsir5	153	26	efficiently	efficiently	RB
cord-254895-ym0jsir5	153	27	.	.	.
cord-254895-ym0jsir5	154	1	Upon	upon	IN
cord-254895-ym0jsir5	154	2	ligand	ligand	NN
cord-254895-ym0jsir5	154	3	binding	bind	VBG
cord-254895-ym0jsir5	154	4	the	the	DT
cord-254895-ym0jsir5	154	5	TIR	TIR	NNP
cord-254895-ym0jsir5	154	6	domain	domain	NN
cord-254895-ym0jsir5	154	7	of	of	IN
cord-254895-ym0jsir5	154	8	TLR9	TLR9	NNP
cord-254895-ym0jsir5	154	9	recruits	recruit	NNS
cord-254895-ym0jsir5	154	10	MyD88	MyD88	NNS
cord-254895-ym0jsir5	154	11	which	which	WDT
cord-254895-ym0jsir5	154	12	forms	form	VBZ
cord-254895-ym0jsir5	154	13	a	a	DT
cord-254895-ym0jsir5	154	14	supramolecular	supramolecular	JJ
cord-254895-ym0jsir5	154	15	complex	complex	NN
cord-254895-ym0jsir5	154	16	with	with	IN
cord-254895-ym0jsir5	154	17	TRAF6	TRAF6	NNP
cord-254895-ym0jsir5	154	18	,	,	,
cord-254895-ym0jsir5	154	19	IRAK1	IRAK1	NNP
cord-254895-ym0jsir5	154	20	,	,	,
cord-254895-ym0jsir5	154	21	IRAK4	IRAK4	NNP
cord-254895-ym0jsir5	154	22	and	and	CC
cord-254895-ym0jsir5	154	23	IRF7	IRF7	NNP
cord-254895-ym0jsir5	155	1	(	(	-LRB-
cord-254895-ym0jsir5	155	2	Honda	Honda	NNP
cord-254895-ym0jsir5	155	3	et	et	NNP
cord-254895-ym0jsir5	155	4	al	al	NNP
cord-254895-ym0jsir5	155	5	.	.	NNP
cord-254895-ym0jsir5	155	6	,	,	,
cord-254895-ym0jsir5	155	7	2004	2004	CD
cord-254895-ym0jsir5	156	1	;	;	:
cord-254895-ym0jsir5	156	2	Kawai	Kawai	NNP
cord-254895-ym0jsir5	156	3	et	et	NNP
cord-254895-ym0jsir5	156	4	al	al	NNP
cord-254895-ym0jsir5	156	5	.	.	NNP
cord-254895-ym0jsir5	156	6	,	,	,
cord-254895-ym0jsir5	156	7	2004	2004	CD
cord-254895-ym0jsir5	156	8	)	)	-RRB-
cord-254895-ym0jsir5	156	9	.	.	.
cord-254895-ym0jsir5	157	1	IRF7	IRF7	NNP
cord-254895-ym0jsir5	157	2	becomes	become	VBZ
cord-254895-ym0jsir5	157	3	activated	activate	VBN
cord-254895-ym0jsir5	157	4	upon	upon	IN
cord-254895-ym0jsir5	157	5	phosphorylation	phosphorylation	NN
cord-254895-ym0jsir5	157	6	which	which	WDT
cord-254895-ym0jsir5	157	7	results	result	VBZ
cord-254895-ym0jsir5	157	8	in	in	IN
cord-254895-ym0jsir5	157	9	homodimerization	homodimerization	NN
cord-254895-ym0jsir5	157	10	of	of	IN
cord-254895-ym0jsir5	157	11	IRF7	IRF7	NNP
cord-254895-ym0jsir5	157	12	or	or	CC
cord-254895-ym0jsir5	157	13	heterodimerization	heterodimerization	NN
cord-254895-ym0jsir5	157	14	of	of	IN
cord-254895-ym0jsir5	157	15	IRF3	IRF3	NNP
cord-254895-ym0jsir5	157	16	and	and	CC
cord-254895-ym0jsir5	157	17	IRF7	IRF7	NNP
cord-254895-ym0jsir5	157	18	.	.	.
cord-254895-ym0jsir5	158	1	These	these	DT
cord-254895-ym0jsir5	158	2	dimers	dimer	NNS
cord-254895-ym0jsir5	158	3	then	then	RB
cord-254895-ym0jsir5	158	4	translocate	translocate	VB
cord-254895-ym0jsir5	158	5	to	to	IN
cord-254895-ym0jsir5	158	6	the	the	DT
cord-254895-ym0jsir5	158	7	nucleus	nucleus	NN
cord-254895-ym0jsir5	158	8	and	and	CC
cord-254895-ym0jsir5	158	9	induce	induce	VB
cord-254895-ym0jsir5	158	10	expression	expression	NN
cord-254895-ym0jsir5	158	11	of	of	IN
cord-254895-ym0jsir5	158	12	type	type	NN
cord-254895-ym0jsir5	159	1	I	-PRON-	PRP
cord-254895-ym0jsir5	159	2	interferon	interferon	VBD
cord-254895-ym0jsir5	159	3	and	and	CC
cord-254895-ym0jsir5	159	4	interferon	interferon	NN
cord-254895-ym0jsir5	159	5	inducible	inducible	JJ
cord-254895-ym0jsir5	159	6	genes	gene	NNS
cord-254895-ym0jsir5	159	7	.	.	.
cord-254895-ym0jsir5	160	1	Several	several	JJ
cord-254895-ym0jsir5	160	2	proteins	protein	NNS
cord-254895-ym0jsir5	160	3	were	be	VBD
cord-254895-ym0jsir5	160	4	implicated	implicate	VBN
cord-254895-ym0jsir5	160	5	in	in	IN
cord-254895-ym0jsir5	160	6	the	the	DT
cord-254895-ym0jsir5	160	7	phosphorylation	phosphorylation	NN
cord-254895-ym0jsir5	160	8	of	of	IN
cord-254895-ym0jsir5	160	9	IRF7	IRF7	NNP
cord-254895-ym0jsir5	160	10	including	include	VBG
cord-254895-ym0jsir5	160	11	IRAK-1	IRAK-1	NNP
cord-254895-ym0jsir5	160	12	,	,	,
cord-254895-ym0jsir5	160	13	IKKa	IKKa	NNS
cord-254895-ym0jsir5	160	14	,	,	,
cord-254895-ym0jsir5	160	15	and	and	CC
cord-254895-ym0jsir5	160	16	a	a	DT
cord-254895-ym0jsir5	160	17	precursor	precursor	NN
cord-254895-ym0jsir5	160	18	of	of	IN
cord-254895-ym0jsir5	160	19	osteopontin	osteopontin	NN
cord-254895-ym0jsir5	160	20	(	(	-LRB-
cord-254895-ym0jsir5	160	21	Hoshino	Hoshino	NNP
cord-254895-ym0jsir5	160	22	et	et	FW
cord-254895-ym0jsir5	160	23	al	al	NNP
cord-254895-ym0jsir5	160	24	.	.	NNP
cord-254895-ym0jsir5	160	25	,	,	,
cord-254895-ym0jsir5	160	26	2006	2006	CD
cord-254895-ym0jsir5	160	27	;	;	:
cord-254895-ym0jsir5	160	28	Shinohara	Shinohara	NNP
cord-254895-ym0jsir5	160	29	et	et	FW
cord-254895-ym0jsir5	160	30	al	al	NNP
cord-254895-ym0jsir5	160	31	.	.	NNP
cord-254895-ym0jsir5	160	32	,	,	,
cord-254895-ym0jsir5	160	33	2006	2006	CD
cord-254895-ym0jsir5	160	34	;	;	:
cord-254895-ym0jsir5	160	35	Uematsu	Uematsu	NNP
cord-254895-ym0jsir5	160	36	et	et	NNP
cord-254895-ym0jsir5	160	37	al	al	NNP
cord-254895-ym0jsir5	160	38	.	.	NNP
cord-254895-ym0jsir5	160	39	,	,	,
cord-254895-ym0jsir5	160	40	2005	2005	CD
cord-254895-ym0jsir5	160	41	)	)	-RRB-
cord-254895-ym0jsir5	160	42	.	.	.
cord-254895-ym0jsir5	161	1	Lack	lack	NN
cord-254895-ym0jsir5	161	2	of	of	IN
cord-254895-ym0jsir5	161	3	IRAK1	irak1	NN
cord-254895-ym0jsir5	161	4	abolishes	abolish	VBZ
cord-254895-ym0jsir5	161	5	IFN	IFN	NNP
cord-254895-ym0jsir5	161	6	-	-	:
cord-254895-ym0jsir5	161	7	a	a	DT
cord-254895-ym0jsir5	161	8	production	production	NN
cord-254895-ym0jsir5	161	9	and	and	CC
cord-254895-ym0jsir5	161	10	IRF7	IRF7	NNP
cord-254895-ym0jsir5	161	11	activation	activation	NN
cord-254895-ym0jsir5	161	12	in	in	IN
cord-254895-ym0jsir5	161	13	response	response	NN
cord-254895-ym0jsir5	161	14	to	to	IN
cord-254895-ym0jsir5	161	15	TLR7	TLR7	NNP
cord-254895-ym0jsir5	161	16	,	,	,
cord-254895-ym0jsir5	161	17	TLR8	TLR8	NNP
cord-254895-ym0jsir5	161	18	and	and	CC
cord-254895-ym0jsir5	161	19	TLR9	tlr9	JJ
cord-254895-ym0jsir5	161	20	ligands	ligand	NNS
cord-254895-ym0jsir5	161	21	.	.	.
cord-254895-ym0jsir5	162	1	IRF7	IRF7	NNP
cord-254895-ym0jsir5	162	2	plays	play	VBZ
cord-254895-ym0jsir5	162	3	the	the	DT
cord-254895-ym0jsir5	162	4	role	role	NN
cord-254895-ym0jsir5	162	5	of	of	IN
cord-254895-ym0jsir5	162	6	a	a	DT
cord-254895-ym0jsir5	162	7	'	'	''
cord-254895-ym0jsir5	162	8	'	'	''
cord-254895-ym0jsir5	162	9	master	master	NN
cord-254895-ym0jsir5	162	10	regulator	regulator	NN
cord-254895-ym0jsir5	162	11	'	'	''
cord-254895-ym0jsir5	162	12	'	'	''
cord-254895-ym0jsir5	162	13	in	in	IN
cord-254895-ym0jsir5	162	14	the	the	DT
cord-254895-ym0jsir5	162	15	induction	induction	NN
cord-254895-ym0jsir5	162	16	of	of	IN
cord-254895-ym0jsir5	162	17	type	type	NN
cord-254895-ym0jsir5	163	1	I	-PRON-	PRP
cord-254895-ym0jsir5	163	2	interferon	interferon	VBD
cord-254895-ym0jsir5	163	3	and	and	CC
cord-254895-ym0jsir5	163	4	IFN	IFN	NNP
cord-254895-ym0jsir5	163	5	inducible	inducible	JJ
cord-254895-ym0jsir5	163	6	genes	gene	NNS
cord-254895-ym0jsir5	163	7	in	in	IN
cord-254895-ym0jsir5	163	8	response	response	NN
cord-254895-ym0jsir5	163	9	to	to	IN
cord-254895-ym0jsir5	163	10	viruses	virus	NNS
cord-254895-ym0jsir5	163	11	(	(	-LRB-
cord-254895-ym0jsir5	163	12	Honda	Honda	NNP
cord-254895-ym0jsir5	163	13	et	et	NNP
cord-254895-ym0jsir5	163	14	al	al	NNP
cord-254895-ym0jsir5	163	15	.	.	NNP
cord-254895-ym0jsir5	163	16	,	,	,
cord-254895-ym0jsir5	163	17	2005a	2005a	CD
cord-254895-ym0jsir5	163	18	)	)	-RRB-
cord-254895-ym0jsir5	163	19	.	.	.
cord-254895-ym0jsir5	164	1	The	the	DT
cord-254895-ym0jsir5	164	2	currently	currently	RB
cord-254895-ym0jsir5	164	3	accepted	accept	VBN
cord-254895-ym0jsir5	164	4	two	two	CD
cord-254895-ym0jsir5	164	5	step	step	NN
cord-254895-ym0jsir5	164	6	model	model	NN
cord-254895-ym0jsir5	164	7	of	of	IN
cord-254895-ym0jsir5	164	8	positive	positive	JJ
cord-254895-ym0jsir5	164	9	feedback	feedback	NN
cord-254895-ym0jsir5	164	10	regulation	regulation	NN
cord-254895-ym0jsir5	164	11	of	of	IN
cord-254895-ym0jsir5	164	12	type	type	NN
cord-254895-ym0jsir5	165	1	I	-PRON-	PRP
cord-254895-ym0jsir5	165	2	interferon	interferon	RB
cord-254895-ym0jsir5	165	3	gene	gene	NN
cord-254895-ym0jsir5	165	4	expression	expression	NN
cord-254895-ym0jsir5	165	5	consists	consist	VBZ
cord-254895-ym0jsir5	165	6	of	of	IN
cord-254895-ym0jsir5	165	7	an	an	DT
cord-254895-ym0jsir5	165	8	initial	initial	JJ
cord-254895-ym0jsir5	165	9	phase	phase	NN
cord-254895-ym0jsir5	165	10	with	with	IN
cord-254895-ym0jsir5	165	11	activation	activation	NN
cord-254895-ym0jsir5	165	12	of	of	IN
cord-254895-ym0jsir5	165	13	IRF7	IRF7	NNP
cord-254895-ym0jsir5	165	14	expressed	express	VBD
cord-254895-ym0jsir5	165	15	constitutively	constitutively	RB
cord-254895-ym0jsir5	165	16	at	at	IN
cord-254895-ym0jsir5	165	17	low	low	JJ
cord-254895-ym0jsir5	165	18	levels	level	NNS
cord-254895-ym0jsir5	165	19	,	,	,
cord-254895-ym0jsir5	165	20	formation	formation	NN
cord-254895-ym0jsir5	165	21	of	of	IN
cord-254895-ym0jsir5	165	22	IRF7-homodimers	IRF7-homodimers	NNPS
cord-254895-ym0jsir5	165	23	or	or	CC
cord-254895-ym0jsir5	165	24	IRF7	IRF7	NNP
cord-254895-ym0jsir5	165	25	/	/	SYM
cord-254895-ym0jsir5	165	26	IRF3-heterodimers	irf3-heterodimer	NNS
cord-254895-ym0jsir5	165	27	and	and	CC
cord-254895-ym0jsir5	165	28	induction	induction	NN
cord-254895-ym0jsir5	165	29	of	of	IN
cord-254895-ym0jsir5	165	30	small	small	JJ
cord-254895-ym0jsir5	165	31	amounts	amount	NNS
cord-254895-ym0jsir5	165	32	of	of	IN
cord-254895-ym0jsir5	165	33	IFN	IFN	NNP
cord-254895-ym0jsir5	165	34	-	-	HYPH
cord-254895-ym0jsir5	165	35	b	b	NNP
cord-254895-ym0jsir5	165	36	/	/	SYM
cord-254895-ym0jsir5	165	37	IFN	IFN	NNP
cord-254895-ym0jsir5	165	38	-	-	HYPH
cord-254895-ym0jsir5	165	39	a	a	NNP
cord-254895-ym0jsir5	165	40	and	and	CC
cord-254895-ym0jsir5	165	41	chemokines	chemokine	NNS
cord-254895-ym0jsir5	165	42	.	.	.
cord-254895-ym0jsir5	166	1	During	during	IN
cord-254895-ym0jsir5	166	2	the	the	DT
cord-254895-ym0jsir5	166	3	second	second	JJ
cord-254895-ym0jsir5	166	4	phase	phase	NN
cord-254895-ym0jsir5	166	5	secreted	secrete	VBN
cord-254895-ym0jsir5	166	6	type	type	NN
cord-254895-ym0jsir5	166	7	I	-PRON-	PRP
cord-254895-ym0jsir5	166	8	IFNs	ifns	VBP
cord-254895-ym0jsir5	166	9	signal	signal	NN
cord-254895-ym0jsir5	166	10	via	via	IN
cord-254895-ym0jsir5	166	11	type	type	NN
cord-254895-ym0jsir5	166	12	I	-PRON-	PRP
cord-254895-ym0jsir5	166	13	IFN	IFN	NNP
cord-254895-ym0jsir5	166	14	receptor	receptor	NN
cord-254895-ym0jsir5	166	15	in	in	IN
cord-254895-ym0jsir5	166	16	an	an	DT
cord-254895-ym0jsir5	166	17	autocrine	autocrine	NN
cord-254895-ym0jsir5	166	18	and	and	CC
cord-254895-ym0jsir5	166	19	paracrine	paracrine	JJ
cord-254895-ym0jsir5	166	20	manner	manner	NN
cord-254895-ym0jsir5	166	21	.	.	.
cord-254895-ym0jsir5	167	1	Downstream	downstream	JJ
cord-254895-ym0jsir5	167	2	signaling	signaling	NN
cord-254895-ym0jsir5	167	3	of	of	IN
cord-254895-ym0jsir5	167	4	the	the	DT
cord-254895-ym0jsir5	167	5	type	type	NN
cord-254895-ym0jsir5	168	1	I	-PRON-	PRP
cord-254895-ym0jsir5	168	2	IFN	IFN	NNP
cord-254895-ym0jsir5	168	3	receptor	receptor	NN
cord-254895-ym0jsir5	168	4	induces	induce	VBZ
cord-254895-ym0jsir5	168	5	a	a	DT
cord-254895-ym0jsir5	168	6	strong	strong	JJ
cord-254895-ym0jsir5	168	7	up	up	NN
cord-254895-ym0jsir5	168	8	-	-	HYPH
cord-254895-ym0jsir5	168	9	regulation	regulation	NN
cord-254895-ym0jsir5	168	10	of	of	IN
cord-254895-ym0jsir5	168	11	IRF7	IRF7	NNP
cord-254895-ym0jsir5	168	12	production	production	NN
cord-254895-ym0jsir5	168	13	leading	lead	VBG
cord-254895-ym0jsir5	168	14	to	to	IN
cord-254895-ym0jsir5	168	15	full	full	JJ
cord-254895-ym0jsir5	168	16	expression	expression	NN
cord-254895-ym0jsir5	168	17	of	of	IN
cord-254895-ym0jsir5	168	18	type	type	NN
cord-254895-ym0jsir5	169	1	I	-PRON-	PRP
cord-254895-ym0jsir5	169	2	IFN	IFN	NNP
cord-254895-ym0jsir5	169	3	genes	gene	NNS
cord-254895-ym0jsir5	169	4	(	(	-LRB-
cord-254895-ym0jsir5	169	5	positive	positive	JJ
cord-254895-ym0jsir5	169	6	feedback	feedback	NN
cord-254895-ym0jsir5	169	7	loop	loop	NN
cord-254895-ym0jsir5	169	8	)	)	-RRB-
cord-254895-ym0jsir5	169	9	.	.	.
cord-254895-ym0jsir5	170	1	Although	although	IN
cord-254895-ym0jsir5	170	2	pDCs	pdcs	XX
cord-254895-ym0jsir5	170	3	constitutively	constitutively	RB
cord-254895-ym0jsir5	170	4	express	express	VB
cord-254895-ym0jsir5	170	5	IRF7	IRF7	NNP
cord-254895-ym0jsir5	170	6	at	at	IN
cord-254895-ym0jsir5	170	7	higher	high	JJR
cord-254895-ym0jsir5	170	8	levels	level	NNS
cord-254895-ym0jsir5	170	9	than	than	IN
cord-254895-ym0jsir5	170	10	other	other	JJ
cord-254895-ym0jsir5	170	11	cells	cell	NNS
cord-254895-ym0jsir5	170	12	,	,	,
cord-254895-ym0jsir5	170	13	they	-PRON-	PRP
cord-254895-ym0jsir5	170	14	also	also	RB
cord-254895-ym0jsir5	170	15	depend	depend	VBP
cord-254895-ym0jsir5	170	16	on	on	IN
cord-254895-ym0jsir5	170	17	further	further	JJ
cord-254895-ym0jsir5	170	18	up	up	NN
cord-254895-ym0jsir5	170	19	-	-	HYPH
cord-254895-ym0jsir5	170	20	regulation	regulation	NN
cord-254895-ym0jsir5	170	21	of	of	IN
cord-254895-ym0jsir5	170	22	IRF7	IRF7	NNP
cord-254895-ym0jsir5	170	23	by	by	IN
cord-254895-ym0jsir5	170	24	type	type	NN
cord-254895-ym0jsir5	171	1	I	-PRON-	PRP
cord-254895-ym0jsir5	171	2	IFN	IFN	NNP
cord-254895-ym0jsir5	171	3	signaling	signal	VBG
cord-254895-ym0jsir5	171	4	to	to	TO
cord-254895-ym0jsir5	171	5	be	be	VB
cord-254895-ym0jsir5	171	6	able	able	JJ
cord-254895-ym0jsir5	171	7	to	to	TO
cord-254895-ym0jsir5	171	8	sustain	sustain	VB
cord-254895-ym0jsir5	171	9	high	high	JJ
cord-254895-ym0jsir5	171	10	level	level	NN
cord-254895-ym0jsir5	171	11	production	production	NN
cord-254895-ym0jsir5	171	12	of	of	IN
cord-254895-ym0jsir5	171	13	type	type	NN
cord-254895-ym0jsir5	172	1	I	-PRON-	PRP
cord-254895-ym0jsir5	172	2	IFNs	ifn	VBD
cord-254895-ym0jsir5	172	3	Honda	Honda	NNP
cord-254895-ym0jsir5	172	4	et	et	NNP
cord-254895-ym0jsir5	172	5	al	al	NNP
cord-254895-ym0jsir5	172	6	.	.	NNP
cord-254895-ym0jsir5	172	7	,	,	,
cord-254895-ym0jsir5	172	8	2005b	2005b	CD
cord-254895-ym0jsir5	172	9	)	)	-RRB-
cord-254895-ym0jsir5	172	10	.	.	.
cord-254895-ym0jsir5	173	1	In	in	IN
cord-254895-ym0jsir5	173	2	contrast	contrast	NN
cord-254895-ym0jsir5	173	3	to	to	IN
cord-254895-ym0jsir5	173	4	pDCs	pDCs	NNP
cord-254895-ym0jsir5	173	5	,	,	,
cord-254895-ym0jsir5	173	6	type	type	NN
cord-254895-ym0jsir5	173	7	I	-PRON-	PRP
cord-254895-ym0jsir5	173	8	IFN	IFN	NNP
cord-254895-ym0jsir5	173	9	production	production	NN
cord-254895-ym0jsir5	173	10	in	in	IN
cord-254895-ym0jsir5	173	11	myeloid	myeloid	JJ
cord-254895-ym0jsir5	173	12	DCs	dc	NNS
cord-254895-ym0jsir5	173	13	in	in	IN
cord-254895-ym0jsir5	173	14	response	response	NN
cord-254895-ym0jsir5	173	15	to	to	IN
cord-254895-ym0jsir5	173	16	DNA	dna	NN
cord-254895-ym0jsir5	173	17	viruses	virus	NNS
cord-254895-ym0jsir5	173	18	is	be	VBZ
cord-254895-ym0jsir5	173	19	mediated	mediate	VBN
cord-254895-ym0jsir5	173	20	by	by	IN
cord-254895-ym0jsir5	173	21	both	both	CC
cord-254895-ym0jsir5	173	22	TLR9-dependent	TLR9-dependent	NNP
cord-254895-ym0jsir5	173	23	and	and	CC
cord-254895-ym0jsir5	173	24	TLR9	TLR9	NNP
cord-254895-ym0jsir5	173	25	/	/	SYM
cord-254895-ym0jsir5	173	26	MyD88-independent	MyD88-independent	NNP
cord-254895-ym0jsir5	173	27	pathways	pathway	NNS
cord-254895-ym0jsir5	173	28	.	.	.
cord-254895-ym0jsir5	174	1	Downstream	downstream	JJ
cord-254895-ym0jsir5	174	2	signaling	signaling	NN
cord-254895-ym0jsir5	174	3	of	of	IN
cord-254895-ym0jsir5	174	4	TLR9	TLR9	NNP
cord-254895-ym0jsir5	174	5	in	in	IN
cord-254895-ym0jsir5	174	6	murine	murine	JJ
cord-254895-ym0jsir5	174	7	myeloid	myeloid	JJ
cord-254895-ym0jsir5	174	8	DCs	dc	NNS
cord-254895-ym0jsir5	174	9	shows	show	VBZ
cord-254895-ym0jsir5	174	10	differences	difference	NNS
cord-254895-ym0jsir5	174	11	compared	compare	VBN
cord-254895-ym0jsir5	174	12	to	to	IN
cord-254895-ym0jsir5	174	13	pDCs	pDCs	NNP
cord-254895-ym0jsir5	174	14	.	.	.
cord-254895-ym0jsir5	175	1	In	in	IN
cord-254895-ym0jsir5	175	2	myeloid	myeloid	JJ
cord-254895-ym0jsir5	175	3	DCs	DCs	NNP
cord-254895-ym0jsir5	175	4	IRF1	IRF1	NNP
cord-254895-ym0jsir5	175	5	plays	play	VBZ
cord-254895-ym0jsir5	175	6	a	a	DT
cord-254895-ym0jsir5	175	7	crucial	crucial	JJ
cord-254895-ym0jsir5	175	8	role	role	NN
cord-254895-ym0jsir5	175	9	in	in	IN
cord-254895-ym0jsir5	175	10	the	the	DT
cord-254895-ym0jsir5	175	11	downstream	downstream	JJ
cord-254895-ym0jsir5	175	12	signaling	signaling	NN
cord-254895-ym0jsir5	175	13	of	of	IN
cord-254895-ym0jsir5	175	14	TLR9	TLR9	NNP
cord-254895-ym0jsir5	175	15	.	.	.
cord-254895-ym0jsir5	176	1	IRF1	IRF1	NNP
cord-254895-ym0jsir5	176	2	À	à	NN
cord-254895-ym0jsir5	176	3	/	/	SYM
cord-254895-ym0jsir5	176	4	À	à	NN
cord-254895-ym0jsir5	176	5	mice	mouse	NNS
cord-254895-ym0jsir5	176	6	show	show	VBP
cord-254895-ym0jsir5	176	7	an	an	DT
cord-254895-ym0jsir5	176	8	impaired	impaired	JJ
cord-254895-ym0jsir5	176	9	induction	induction	NN
cord-254895-ym0jsir5	176	10	of	of	IN
cord-254895-ym0jsir5	176	11	IFN	IFN	NNP
cord-254895-ym0jsir5	176	12	-	-	HYPH
cord-254895-ym0jsir5	176	13	b	b	NNP
cord-254895-ym0jsir5	176	14	,	,	,
cord-254895-ym0jsir5	176	15	iNOS	inos	NN
cord-254895-ym0jsir5	176	16	and	and	CC
cord-254895-ym0jsir5	176	17	IL-12p35	IL-12p35	NNP
cord-254895-ym0jsir5	176	18	upon	upon	IN
cord-254895-ym0jsir5	176	19	stimulation	stimulation	NN
cord-254895-ym0jsir5	176	20	with	with	IN
cord-254895-ym0jsir5	176	21	TLR9	TLR9	NNP
cord-254895-ym0jsir5	176	22	ligand	ligand	NN
cord-254895-ym0jsir5	176	23	CpG	cpg	NN
cord-254895-ym0jsir5	176	24	-	-	HYPH
cord-254895-ym0jsir5	176	25	B	B	NNP
cord-254895-ym0jsir5	176	26	,	,	,
cord-254895-ym0jsir5	176	27	whereas	whereas	IN
cord-254895-ym0jsir5	176	28	type	type	NN
cord-254895-ym0jsir5	176	29	I	-PRON-	PRP
cord-254895-ym0jsir5	176	30	interferon	interferon	VBD
cord-254895-ym0jsir5	176	31	response	response	NN
cord-254895-ym0jsir5	176	32	of	of	IN
cord-254895-ym0jsir5	176	33	pDCs	pDCs	NNP
cord-254895-ym0jsir5	176	34	is	be	VBZ
cord-254895-ym0jsir5	176	35	not	not	RB
cord-254895-ym0jsir5	176	36	affected	affect	VBN
cord-254895-ym0jsir5	176	37	by	by	IN
cord-254895-ym0jsir5	176	38	lack	lack	NN
cord-254895-ym0jsir5	176	39	of	of	IN
cord-254895-ym0jsir5	176	40	IRF1	IRF1	NNP
cord-254895-ym0jsir5	176	41	(	(	-LRB-
cord-254895-ym0jsir5	176	42	Negishi	Negishi	NNP
cord-254895-ym0jsir5	176	43	et	et	NNP
cord-254895-ym0jsir5	176	44	al	al	NNP
cord-254895-ym0jsir5	176	45	.	.	NNP
cord-254895-ym0jsir5	176	46	,	,	,
cord-254895-ym0jsir5	176	47	2006	2006	CD
cord-254895-ym0jsir5	176	48	;	;	.
cord-254895-ym0jsir5	177	1	Schmitz	Schmitz	NNP
cord-254895-ym0jsir5	177	2	et	et	NNP
cord-254895-ym0jsir5	177	3	al	al	NNP
cord-254895-ym0jsir5	177	4	.	.	NNP
cord-254895-ym0jsir5	177	5	,	,	,
cord-254895-ym0jsir5	177	6	2007	2007	CD
cord-254895-ym0jsir5	177	7	)	)	-RRB-
cord-254895-ym0jsir5	177	8	.	.	.
cord-254895-ym0jsir5	178	1	What	what	WP
cord-254895-ym0jsir5	178	2	is	be	VBZ
cord-254895-ym0jsir5	178	3	the	the	DT
cord-254895-ym0jsir5	178	4	role	role	NN
cord-254895-ym0jsir5	178	5	of	of	IN
cord-254895-ym0jsir5	178	6	TLR9	TLR9	NNP
cord-254895-ym0jsir5	178	7	for	for	IN
cord-254895-ym0jsir5	178	8	antiviral	antiviral	JJ
cord-254895-ym0jsir5	178	9	immunity	immunity	NN
cord-254895-ym0jsir5	178	10	in	in	IN
cord-254895-ym0jsir5	178	11	vivo	vivo	NN
cord-254895-ym0jsir5	178	12	?	?	.
cord-254895-ym0jsir5	179	1	Several	several	JJ
cord-254895-ym0jsir5	179	2	studies	study	NNS
cord-254895-ym0jsir5	179	3	have	have	VBP
cord-254895-ym0jsir5	179	4	described	describe	VBN
cord-254895-ym0jsir5	179	5	increased	increase	VBN
cord-254895-ym0jsir5	179	6	susceptibility	susceptibility	NN
cord-254895-ym0jsir5	179	7	of	of	IN
cord-254895-ym0jsir5	179	8	TLR9	TLR9	NNP
cord-254895-ym0jsir5	179	9	À	à	NN
cord-254895-ym0jsir5	179	10	/	/	SYM
cord-254895-ym0jsir5	179	11	À	à	NN
cord-254895-ym0jsir5	179	12	mice	mouse	NNS
cord-254895-ym0jsir5	179	13	to	to	IN
cord-254895-ym0jsir5	179	14	systemic	systemic	JJ
cord-254895-ym0jsir5	179	15	murine	murine	JJ
cord-254895-ym0jsir5	179	16	cytomegalovirus	cytomegalovirus	NN
cord-254895-ym0jsir5	179	17	(	(	-LRB-
cord-254895-ym0jsir5	179	18	MCMV	MCMV	NNP
cord-254895-ym0jsir5	179	19	)	)	-RRB-
cord-254895-ym0jsir5	179	20	infection	infection	NN
cord-254895-ym0jsir5	179	21	(	(	-LRB-
cord-254895-ym0jsir5	179	22	Tabeta	Tabeta	NNP
cord-254895-ym0jsir5	179	23	et	et	FW
cord-254895-ym0jsir5	179	24	al	al	NNP
cord-254895-ym0jsir5	179	25	.	.	.
cord-254895-ym0jsir5	179	26	2004	2004	CD
cord-254895-ym0jsir5	179	27	;	;	:
cord-254895-ym0jsir5	179	28	Krug	Krug	NNP
cord-254895-ym0jsir5	179	29	et	et	NNP
cord-254895-ym0jsir5	179	30	al	al	NNP
cord-254895-ym0jsir5	179	31	.	.	NNP
cord-254895-ym0jsir5	179	32	,	,	,
cord-254895-ym0jsir5	179	33	2004a	2004a	CD
cord-254895-ym0jsir5	179	34	;	;	:
cord-254895-ym0jsir5	179	35	Delale	Delale	NNP
cord-254895-ym0jsir5	179	36	et	et	NNP
cord-254895-ym0jsir5	179	37	al	al	NNP
cord-254895-ym0jsir5	179	38	.	.	NNP
cord-254895-ym0jsir5	179	39	,	,	,
cord-254895-ym0jsir5	179	40	2005	2005	CD
cord-254895-ym0jsir5	179	41	)	)	-RRB-
cord-254895-ym0jsir5	179	42	.	.	.
cord-254895-ym0jsir5	180	1	We	-PRON-	PRP
cord-254895-ym0jsir5	180	2	could	could	MD
cord-254895-ym0jsir5	180	3	show	show	VB
cord-254895-ym0jsir5	180	4	that	that	IN
cord-254895-ym0jsir5	180	5	TLR9-dependent	TLR9-dependent	NNP
cord-254895-ym0jsir5	180	6	recognition	recognition	NN
cord-254895-ym0jsir5	180	7	of	of	IN
cord-254895-ym0jsir5	180	8	MCMV	MCMV	NNP
cord-254895-ym0jsir5	180	9	by	by	IN
cord-254895-ym0jsir5	180	10	pDCs	pDCs	NNP
cord-254895-ym0jsir5	180	11	and	and	CC
cord-254895-ym0jsir5	180	12	conventional	conventional	JJ
cord-254895-ym0jsir5	180	13	DC	DC	NNP
cord-254895-ym0jsir5	180	14	is	be	VBZ
cord-254895-ym0jsir5	180	15	clearly	clearly	RB
cord-254895-ym0jsir5	180	16	involved	involve	VBN
cord-254895-ym0jsir5	180	17	in	in	IN
cord-254895-ym0jsir5	180	18	the	the	DT
cord-254895-ym0jsir5	180	19	innate	innate	JJ
cord-254895-ym0jsir5	180	20	immune	immune	JJ
cord-254895-ym0jsir5	180	21	response	response	NN
cord-254895-ym0jsir5	180	22	to	to	IN
cord-254895-ym0jsir5	180	23	MCMV	MCMV	NNP
cord-254895-ym0jsir5	180	24	.	.	.
cord-254895-ym0jsir5	181	1	In	in	IN
cord-254895-ym0jsir5	181	2	the	the	DT
cord-254895-ym0jsir5	181	3	very	very	RB
cord-254895-ym0jsir5	181	4	early	early	JJ
cord-254895-ym0jsir5	181	5	phase	phase	NN
cord-254895-ym0jsir5	181	6	of	of	IN
cord-254895-ym0jsir5	181	7	systemic	systemic	JJ
cord-254895-ym0jsir5	181	8	MCMV	MCMV	NNP
cord-254895-ym0jsir5	181	9	infection	infection	NN
cord-254895-ym0jsir5	181	10	pDCs	pdcs	NN
cord-254895-ym0jsir5	181	11	and	and	CC
cord-254895-ym0jsir5	181	12	conventional	conventional	JJ
cord-254895-ym0jsir5	181	13	DCs	dc	NNS
cord-254895-ym0jsir5	181	14	release	release	VBP
cord-254895-ym0jsir5	181	15	the	the	DT
cord-254895-ym0jsir5	181	16	first	first	JJ
cord-254895-ym0jsir5	181	17	wave	wave	NN
cord-254895-ym0jsir5	181	18	of	of	IN
cord-254895-ym0jsir5	181	19	type	type	NN
cord-254895-ym0jsir5	181	20	I	-PRON-	PRP
cord-254895-ym0jsir5	181	21	interferons	interferon	NNS
cord-254895-ym0jsir5	181	22	and	and	CC
cord-254895-ym0jsir5	181	23	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	181	24	cytokines	cytokine	NNS
cord-254895-ym0jsir5	181	25	including	include	VBG
cord-254895-ym0jsir5	181	26	IL-12	IL-12	NNP
cord-254895-ym0jsir5	181	27	.	.	.
cord-254895-ym0jsir5	182	1	The	the	DT
cord-254895-ym0jsir5	182	2	expression	expression	NN
cord-254895-ym0jsir5	182	3	of	of	IN
cord-254895-ym0jsir5	182	4	these	these	DT
cord-254895-ym0jsir5	182	5	cytokines	cytokine	NNS
cord-254895-ym0jsir5	182	6	peaks	peak	NNS
cord-254895-ym0jsir5	182	7	between	between	IN
cord-254895-ym0jsir5	182	8	36	36	CD
cord-254895-ym0jsir5	182	9	and	and	CC
cord-254895-ym0jsir5	182	10	38	38	CD
cord-254895-ym0jsir5	182	11	h	h	NN
cord-254895-ym0jsir5	182	12	postinfection	postinfection	NN
cord-254895-ym0jsir5	183	1	(	(	-LRB-
cord-254895-ym0jsir5	183	2	Dalod	Dalod	NNP
cord-254895-ym0jsir5	183	3	et	et	FW
cord-254895-ym0jsir5	183	4	al	al	NNP
cord-254895-ym0jsir5	183	5	.	.	.
cord-254895-ym0jsir5	184	1	,	,	,
cord-254895-ym0jsir5	184	2	2002	2002	CD
cord-254895-ym0jsir5	184	3	;	;	:
cord-254895-ym0jsir5	184	4	Orange	Orange	NNP
cord-254895-ym0jsir5	184	5	and	and	CC
cord-254895-ym0jsir5	184	6	Biron	Biron	NNP
cord-254895-ym0jsir5	184	7	,	,	,
cord-254895-ym0jsir5	184	8	1996b	1996b	CD
cord-254895-ym0jsir5	184	9	)	)	-RRB-
cord-254895-ym0jsir5	184	10	and	and	CC
cord-254895-ym0jsir5	184	11	triggers	trigger	VBZ
cord-254895-ym0jsir5	184	12	non	non	JJ
cord-254895-ym0jsir5	184	13	-	-	JJ
cord-254895-ym0jsir5	184	14	specific	specific	JJ
cord-254895-ym0jsir5	184	15	NK	NK	NNP
cord-254895-ym0jsir5	184	16	cell	cell	NN
cord-254895-ym0jsir5	184	17	activation	activation	NN
cord-254895-ym0jsir5	184	18	at	at	IN
cord-254895-ym0jsir5	184	19	this	this	DT
cord-254895-ym0jsir5	184	20	time	time	NN
cord-254895-ym0jsir5	184	21	point	point	NN
cord-254895-ym0jsir5	184	22	.	.	.
cord-254895-ym0jsir5	185	1	Control	control	NN
cord-254895-ym0jsir5	185	2	of	of	IN
cord-254895-ym0jsir5	185	3	viral	viral	JJ
cord-254895-ym0jsir5	185	4	replication	replication	NN
cord-254895-ym0jsir5	185	5	and	and	CC
cord-254895-ym0jsir5	185	6	clearance	clearance	NN
cord-254895-ym0jsir5	185	7	of	of	IN
cord-254895-ym0jsir5	185	8	the	the	DT
cord-254895-ym0jsir5	185	9	virus	virus	NN
cord-254895-ym0jsir5	185	10	from	from	IN
cord-254895-ym0jsir5	185	11	infected	infected	JJ
cord-254895-ym0jsir5	185	12	organs	organ	NNS
cord-254895-ym0jsir5	185	13	during	during	IN
cord-254895-ym0jsir5	185	14	the	the	DT
cord-254895-ym0jsir5	185	15	first	first	JJ
cord-254895-ym0jsir5	185	16	week	week	NN
cord-254895-ym0jsir5	185	17	of	of	IN
cord-254895-ym0jsir5	185	18	MCMV	MCMV	NNP
cord-254895-ym0jsir5	185	19	infection	infection	NN
cord-254895-ym0jsir5	185	20	relies	rely	VBZ
cord-254895-ym0jsir5	185	21	mostly	mostly	RB
cord-254895-ym0jsir5	185	22	on	on	IN
cord-254895-ym0jsir5	185	23	NK	NK	NNP
cord-254895-ym0jsir5	185	24	cells	cell	NNS
cord-254895-ym0jsir5	185	25	,	,	,
cord-254895-ym0jsir5	185	26	which	which	WDT
cord-254895-ym0jsir5	185	27	produce	produce	VBP
cord-254895-ym0jsir5	185	28	IFN	IFN	NNP
cord-254895-ym0jsir5	185	29	-	-	HYPH
cord-254895-ym0jsir5	185	30	g	g	NNP
cord-254895-ym0jsir5	185	31	(	(	-LRB-
cord-254895-ym0jsir5	185	32	mediated	mediate	VBN
cord-254895-ym0jsir5	185	33	by	by	IN
cord-254895-ym0jsir5	185	34	IL-12	IL-12	NNP
cord-254895-ym0jsir5	185	35	and	and	CC
cord-254895-ym0jsir5	185	36	IL-18	IL-18	NNP
cord-254895-ym0jsir5	185	37	)	)	-RRB-
cord-254895-ym0jsir5	185	38	and	and	CC
cord-254895-ym0jsir5	185	39	kill	kill	VB
cord-254895-ym0jsir5	185	40	infected	infected	JJ
cord-254895-ym0jsir5	185	41	cells	cell	NNS
cord-254895-ym0jsir5	185	42	(	(	-LRB-
cord-254895-ym0jsir5	185	43	Orange	Orange	NNP
cord-254895-ym0jsir5	185	44	and	and	CC
cord-254895-ym0jsir5	185	45	Biron	Biron	NNP
cord-254895-ym0jsir5	185	46	,	,	,
cord-254895-ym0jsir5	185	47	1996a	1996a	CD
cord-254895-ym0jsir5	185	48	)	)	-RRB-
cord-254895-ym0jsir5	185	49	.	.	.
cord-254895-ym0jsir5	186	1	We	-PRON-	PRP
cord-254895-ym0jsir5	186	2	found	find	VBD
cord-254895-ym0jsir5	186	3	a	a	DT
cord-254895-ym0jsir5	186	4	significant	significant	JJ
cord-254895-ym0jsir5	186	5	reduction	reduction	NN
cord-254895-ym0jsir5	186	6	in	in	IN
cord-254895-ym0jsir5	186	7	IFN	IFN	NNP
cord-254895-ym0jsir5	186	8	-	-	HYPH
cord-254895-ym0jsir5	186	9	a	a	NN
cord-254895-ym0jsir5	186	10	and	and	CC
cord-254895-ym0jsir5	186	11	IL-12	IL-12	NNP
cord-254895-ym0jsir5	186	12	serum	serum	NN
cord-254895-ym0jsir5	186	13	levels	level	NNS
cord-254895-ym0jsir5	186	14	in	in	IN
cord-254895-ym0jsir5	186	15	TLR9-and	tlr9-and	NN
cord-254895-ym0jsir5	186	16	MyD88-deficient	MyD88-deficient	NNP
cord-254895-ym0jsir5	186	17	mice	mouse	NNS
cord-254895-ym0jsir5	186	18	at	at	IN
cord-254895-ym0jsir5	186	19	36	36	CD
cord-254895-ym0jsir5	186	20	h	h	NN
cord-254895-ym0jsir5	186	21	after	after	IN
cord-254895-ym0jsir5	186	22	infection	infection	NN
cord-254895-ym0jsir5	186	23	.	.	.
cord-254895-ym0jsir5	187	1	However	however	RB
cord-254895-ym0jsir5	187	2	,	,	,
cord-254895-ym0jsir5	187	3	IFN	IFN	NNP
cord-254895-ym0jsir5	187	4	-	-	:
cord-254895-ym0jsir5	187	5	a	a	DT
cord-254895-ym0jsir5	187	6	serum	serum	NN
cord-254895-ym0jsir5	187	7	levels	level	NNS
cord-254895-ym0jsir5	187	8	comparable	comparable	JJ
cord-254895-ym0jsir5	187	9	to	to	IN
cord-254895-ym0jsir5	187	10	those	those	DT
cord-254895-ym0jsir5	187	11	of	of	IN
cord-254895-ym0jsir5	187	12	wild	wild	JJ
cord-254895-ym0jsir5	187	13	-	-	HYPH
cord-254895-ym0jsir5	187	14	type	type	NN
cord-254895-ym0jsir5	187	15	mice	mouse	NNS
cord-254895-ym0jsir5	187	16	could	could	MD
cord-254895-ym0jsir5	187	17	be	be	VB
cord-254895-ym0jsir5	187	18	observed	observe	VBN
cord-254895-ym0jsir5	187	19	in	in	IN
cord-254895-ym0jsir5	187	20	TLR9-and	TLR9-and	NNP
cord-254895-ym0jsir5	187	21	MyD88-deficient	MyD88-deficient	NNP
cord-254895-ym0jsir5	187	22	mice	mouse	NNS
cord-254895-ym0jsir5	187	23	at	at	IN
cord-254895-ym0jsir5	187	24	later	later	JJ
cord-254895-ym0jsir5	187	25	time	time	NN
cord-254895-ym0jsir5	187	26	points	point	NNS
cord-254895-ym0jsir5	187	27	suggesting	suggest	VBG
cord-254895-ym0jsir5	187	28	the	the	DT
cord-254895-ym0jsir5	187	29	existence	existence	NN
cord-254895-ym0jsir5	187	30	of	of	IN
cord-254895-ym0jsir5	187	31	an	an	DT
cord-254895-ym0jsir5	187	32	additional	additional	JJ
cord-254895-ym0jsir5	187	33	TLR9	TLR9	NNP
cord-254895-ym0jsir5	187	34	/	/	SYM
cord-254895-ym0jsir5	187	35	MyD88-independent	MyD88-independent	NNP
cord-254895-ym0jsir5	187	36	type	type	NN
cord-254895-ym0jsir5	187	37	I	-PRON-	PRP
cord-254895-ym0jsir5	187	38	IFN	IFN	NNP
cord-254895-ym0jsir5	187	39	induction	induction	NN
cord-254895-ym0jsir5	187	40	mechanism	mechanism	NN
cord-254895-ym0jsir5	187	41	with	with	IN
cord-254895-ym0jsir5	187	42	delayed	delay	VBN
cord-254895-ym0jsir5	187	43	kinetics	kinetic	NNS
cord-254895-ym0jsir5	187	44	.	.	.
cord-254895-ym0jsir5	188	1	Loss	loss	NN
cord-254895-ym0jsir5	188	2	of	of	IN
cord-254895-ym0jsir5	188	3	the	the	DT
cord-254895-ym0jsir5	188	4	early	early	JJ
cord-254895-ym0jsir5	188	5	IFN	IFN	NNP
cord-254895-ym0jsir5	188	6	-	-	:
cord-254895-ym0jsir5	188	7	a	a	DT
cord-254895-ym0jsir5	188	8	peak	peak	NN
cord-254895-ym0jsir5	188	9	is	be	VBZ
cord-254895-ym0jsir5	188	10	due	due	JJ
cord-254895-ym0jsir5	188	11	to	to	IN
cord-254895-ym0jsir5	188	12	an	an	DT
cord-254895-ym0jsir5	188	13	impaired	impaired	JJ
cord-254895-ym0jsir5	188	14	function	function	NN
cord-254895-ym0jsir5	188	15	of	of	IN
cord-254895-ym0jsir5	188	16	pDCs	pdcs	NN
cord-254895-ym0jsir5	188	17	in	in	IN
cord-254895-ym0jsir5	188	18	TLR9	TLR9	NNP
cord-254895-ym0jsir5	188	19	À	à	NN
cord-254895-ym0jsir5	188	20	/	/	SYM
cord-254895-ym0jsir5	188	21	À	à	NN
cord-254895-ym0jsir5	188	22	mice	mouse	NNS
cord-254895-ym0jsir5	188	23	as	as	IN
cord-254895-ym0jsir5	188	24	MCMV	MCMV	NNP
cord-254895-ym0jsir5	188	25	recognition	recognition	NN
cord-254895-ym0jsir5	188	26	and	and	CC
cord-254895-ym0jsir5	188	27	type	type	NN
cord-254895-ym0jsir5	189	1	I	-PRON-	PRP
cord-254895-ym0jsir5	189	2	IFN	IFN	NNP
cord-254895-ym0jsir5	189	3	production	production	NN
cord-254895-ym0jsir5	189	4	are	be	VBP
cord-254895-ym0jsir5	189	5	TLR9dependent	TLR9dependent	NNP
cord-254895-ym0jsir5	189	6	in	in	IN
cord-254895-ym0jsir5	189	7	this	this	DT
cord-254895-ym0jsir5	189	8	cell	cell	NN
cord-254895-ym0jsir5	189	9	type	type	NN
cord-254895-ym0jsir5	189	10	.	.	.
cord-254895-ym0jsir5	190	1	pDC	pDC	NNP
cord-254895-ym0jsir5	190	2	depletion	depletion	NN
cord-254895-ym0jsir5	190	3	in	in	IN
cord-254895-ym0jsir5	190	4	vivo	vivo	NN
cord-254895-ym0jsir5	190	5	led	lead	VBN
cord-254895-ym0jsir5	190	6	to	to	IN
cord-254895-ym0jsir5	190	7	markedly	markedly	RB
cord-254895-ym0jsir5	190	8	reduced	reduce	VBN
cord-254895-ym0jsir5	190	9	IFN	IFN	NNP
cord-254895-ym0jsir5	190	10	-	-	:
cord-254895-ym0jsir5	190	11	a	a	DT
cord-254895-ym0jsir5	190	12	levels	level	NNS
cord-254895-ym0jsir5	190	13	at	at	IN
cord-254895-ym0jsir5	190	14	36	36	CD
cord-254895-ym0jsir5	190	15	h	h	NN
cord-254895-ym0jsir5	190	16	after	after	IN
cord-254895-ym0jsir5	190	17	infection	infection	NN
cord-254895-ym0jsir5	190	18	reflecting	reflect	VBG
cord-254895-ym0jsir5	190	19	their	-PRON-	PRP$
cord-254895-ym0jsir5	190	20	almost	almost	RB
cord-254895-ym0jsir5	190	21	exclusive	exclusive	JJ
cord-254895-ym0jsir5	190	22	role	role	NN
cord-254895-ym0jsir5	190	23	for	for	IN
cord-254895-ym0jsir5	190	24	IFN	IFN	NNP
cord-254895-ym0jsir5	190	25	-	-	:
cord-254895-ym0jsir5	190	26	a	a	DT
cord-254895-ym0jsir5	190	27	production	production	NN
cord-254895-ym0jsir5	190	28	at	at	IN
cord-254895-ym0jsir5	190	29	this	this	DT
cord-254895-ym0jsir5	190	30	early	early	JJ
cord-254895-ym0jsir5	190	31	time	time	NN
cord-254895-ym0jsir5	190	32	point	point	NN
cord-254895-ym0jsir5	190	33	.	.	.
cord-254895-ym0jsir5	191	1	In	in	IN
cord-254895-ym0jsir5	191	2	contrast	contrast	NN
cord-254895-ym0jsir5	191	3	to	to	IN
cord-254895-ym0jsir5	191	4	IFN	IFN	NNP
cord-254895-ym0jsir5	191	5	-	-	HYPH
cord-254895-ym0jsir5	191	6	a	a	NNP
cord-254895-ym0jsir5	191	7	,	,	,
cord-254895-ym0jsir5	191	8	IL-12	IL-12	NNP
cord-254895-ym0jsir5	191	9	production	production	NN
cord-254895-ym0jsir5	191	10	was	be	VBD
cord-254895-ym0jsir5	191	11	severely	severely	RB
cord-254895-ym0jsir5	191	12	impaired	impaired	JJ
cord-254895-ym0jsir5	191	13	in	in	IN
cord-254895-ym0jsir5	191	14	TLR9-and	tlr9-and	NN
cord-254895-ym0jsir5	191	15	MyD88-deficient	MyD88-deficient	NNP
cord-254895-ym0jsir5	191	16	mice	mouse	NNS
cord-254895-ym0jsir5	191	17	at	at	IN
cord-254895-ym0jsir5	191	18	all	all	DT
cord-254895-ym0jsir5	191	19	time	time	NN
cord-254895-ym0jsir5	191	20	points	point	NNS
cord-254895-ym0jsir5	191	21	reflecting	reflect	VBG
cord-254895-ym0jsir5	191	22	the	the	DT
cord-254895-ym0jsir5	191	23	requirement	requirement	NN
cord-254895-ym0jsir5	191	24	of	of	IN
cord-254895-ym0jsir5	191	25	TLR9	TLR9	NNP
cord-254895-ym0jsir5	191	26	for	for	IN
cord-254895-ym0jsir5	191	27	IL-12	IL-12	NNP
cord-254895-ym0jsir5	191	28	responses	response	NNS
cord-254895-ym0jsir5	191	29	to	to	IN
cord-254895-ym0jsir5	191	30	MCMV	MCMV	NNP
cord-254895-ym0jsir5	191	31	in	in	IN
cord-254895-ym0jsir5	191	32	all	all	DT
cord-254895-ym0jsir5	191	33	DC	DC	NNP
cord-254895-ym0jsir5	191	34	subpopulations	subpopulation	NNS
cord-254895-ym0jsir5	191	35	.	.	.
cord-254895-ym0jsir5	192	1	IFN	IFN	NNP
cord-254895-ym0jsir5	192	2	-	-	HYPH
cord-254895-ym0jsir5	192	3	g	g	NN
cord-254895-ym0jsir5	192	4	production	production	NN
cord-254895-ym0jsir5	192	5	by	by	IN
cord-254895-ym0jsir5	192	6	NK	NK	NNP
cord-254895-ym0jsir5	192	7	cells	cell	NNS
cord-254895-ym0jsir5	192	8	which	which	WDT
cord-254895-ym0jsir5	192	9	is	be	VBZ
cord-254895-ym0jsir5	192	10	induced	induce	VBN
cord-254895-ym0jsir5	192	11	by	by	IN
cord-254895-ym0jsir5	192	12	IL-12	IL-12	NNP
cord-254895-ym0jsir5	192	13	and	and	CC
cord-254895-ym0jsir5	192	14	IL-18	IL-18	NNP
cord-254895-ym0jsir5	192	15	was	be	VBD
cord-254895-ym0jsir5	192	16	also	also	RB
cord-254895-ym0jsir5	192	17	significantly	significantly	RB
cord-254895-ym0jsir5	192	18	reduced	reduce	VBN
cord-254895-ym0jsir5	192	19	in	in	IN
cord-254895-ym0jsir5	192	20	the	the	DT
cord-254895-ym0jsir5	192	21	absence	absence	NN
cord-254895-ym0jsir5	192	22	of	of	IN
cord-254895-ym0jsir5	192	23	TLR9	TLR9	NNP
cord-254895-ym0jsir5	192	24	or	or	CC
cord-254895-ym0jsir5	192	25	MyD88	MyD88	NNS
cord-254895-ym0jsir5	192	26	.	.	.
cord-254895-ym0jsir5	193	1	These	these	DT
cord-254895-ym0jsir5	193	2	defects	defect	NNS
cord-254895-ym0jsir5	193	3	in	in	IN
cord-254895-ym0jsir5	193	4	the	the	DT
cord-254895-ym0jsir5	193	5	innate	innate	JJ
cord-254895-ym0jsir5	193	6	immune	immune	JJ
cord-254895-ym0jsir5	193	7	response	response	NN
cord-254895-ym0jsir5	193	8	to	to	IN
cord-254895-ym0jsir5	193	9	MCMV	MCMV	NNP
cord-254895-ym0jsir5	193	10	correlated	correlate	VBD
cord-254895-ym0jsir5	193	11	with	with	IN
cord-254895-ym0jsir5	193	12	higher	high	JJR
cord-254895-ym0jsir5	193	13	viral	viral	JJ
cord-254895-ym0jsir5	193	14	titers	titer	NNS
cord-254895-ym0jsir5	193	15	in	in	IN
cord-254895-ym0jsir5	193	16	spleen	spleen	NNS
cord-254895-ym0jsir5	193	17	and	and	CC
cord-254895-ym0jsir5	193	18	liver	liver	NN
cord-254895-ym0jsir5	193	19	of	of	IN
cord-254895-ym0jsir5	193	20	TLR9	TLR9	NNP
cord-254895-ym0jsir5	193	21	À	à	NN
cord-254895-ym0jsir5	193	22	/	/	SYM
cord-254895-ym0jsir5	193	23	À	à	NN
cord-254895-ym0jsir5	193	24	and	and	CC
cord-254895-ym0jsir5	193	25	MyD88	MyD88	NNP
cord-254895-ym0jsir5	193	26	À	à	NN
cord-254895-ym0jsir5	193	27	/	/	SYM
cord-254895-ym0jsir5	193	28	À	à	NN
cord-254895-ym0jsir5	193	29	mice	mouse	NNS
cord-254895-ym0jsir5	193	30	on	on	IN
cord-254895-ym0jsir5	193	31	the	the	DT
cord-254895-ym0jsir5	193	32	C57BL/6	C57BL/6	NNP
cord-254895-ym0jsir5	193	33	background	background	NN
cord-254895-ym0jsir5	193	34	reflecting	reflect	VBG
cord-254895-ym0jsir5	193	35	increased	increase	VBN
cord-254895-ym0jsir5	193	36	susceptibility	susceptibility	NN
cord-254895-ym0jsir5	193	37	to	to	IN
cord-254895-ym0jsir5	193	38	MCMV	MCMV	NNP
cord-254895-ym0jsir5	193	39	in	in	IN
cord-254895-ym0jsir5	193	40	the	the	DT
cord-254895-ym0jsir5	193	41	early	early	JJ
cord-254895-ym0jsir5	193	42	phase	phase	NN
cord-254895-ym0jsir5	193	43	of	of	IN
cord-254895-ym0jsir5	193	44	the	the	DT
cord-254895-ym0jsir5	193	45	infection	infection	NN
cord-254895-ym0jsir5	193	46	Krug	Krug	NNP
cord-254895-ym0jsir5	193	47	et	et	NNP
cord-254895-ym0jsir5	193	48	al	al	NNP
cord-254895-ym0jsir5	193	49	.	.	NNP
cord-254895-ym0jsir5	193	50	,	,	,
cord-254895-ym0jsir5	193	51	2004a	2004a	CD
cord-254895-ym0jsir5	193	52	)	)	-RRB-
cord-254895-ym0jsir5	193	53	.	.	.
cord-254895-ym0jsir5	194	1	A	a	DT
cord-254895-ym0jsir5	194	2	recent	recent	JJ
cord-254895-ym0jsir5	194	3	report	report	NN
cord-254895-ym0jsir5	194	4	showed	show	VBD
cord-254895-ym0jsir5	194	5	that	that	IN
cord-254895-ym0jsir5	194	6	pDCs	pdcs	XX
cord-254895-ym0jsir5	194	7	which	which	WDT
cord-254895-ym0jsir5	194	8	are	be	VBP
cord-254895-ym0jsir5	194	9	recruited	recruit	VBN
cord-254895-ym0jsir5	194	10	to	to	IN
cord-254895-ym0jsir5	194	11	the	the	DT
cord-254895-ym0jsir5	194	12	vaginal	vaginal	JJ
cord-254895-ym0jsir5	194	13	mucosa	mucosa	NN
cord-254895-ym0jsir5	194	14	after	after	IN
cord-254895-ym0jsir5	194	15	local	local	JJ
cord-254895-ym0jsir5	194	16	infection	infection	NN
cord-254895-ym0jsir5	194	17	with	with	IN
cord-254895-ym0jsir5	194	18	HSV-2	HSV-2	NNS
cord-254895-ym0jsir5	194	19	are	be	VBP
cord-254895-ym0jsir5	194	20	activated	activate	VBN
cord-254895-ym0jsir5	194	21	to	to	TO
cord-254895-ym0jsir5	194	22	produce	produce	VB
cord-254895-ym0jsir5	194	23	type	type	NN
cord-254895-ym0jsir5	195	1	I	-PRON-	PRP
cord-254895-ym0jsir5	195	2	IFN	IFN	NNP
cord-254895-ym0jsir5	195	3	in	in	IN
cord-254895-ym0jsir5	195	4	a	a	DT
cord-254895-ym0jsir5	195	5	TLR9dependent	TLR9dependent	NNP
cord-254895-ym0jsir5	195	6	manner	manner	NN
cord-254895-ym0jsir5	195	7	,	,	,
cord-254895-ym0jsir5	195	8	thus	thus	RB
cord-254895-ym0jsir5	195	9	reducing	reduce	VBG
cord-254895-ym0jsir5	195	10	local	local	JJ
cord-254895-ym0jsir5	195	11	viral	viral	JJ
cord-254895-ym0jsir5	195	12	replication	replication	NN
cord-254895-ym0jsir5	195	13	and	and	CC
cord-254895-ym0jsir5	195	14	pathology	pathology	NN
cord-254895-ym0jsir5	196	1	(	(	-LRB-
cord-254895-ym0jsir5	196	2	Lund	Lund	NNP
cord-254895-ym0jsir5	196	3	et	et	NNP
cord-254895-ym0jsir5	196	4	al	al	NNP
cord-254895-ym0jsir5	196	5	.	.	NNP
cord-254895-ym0jsir5	196	6	,	,	,
cord-254895-ym0jsir5	196	7	2006	2006	CD
cord-254895-ym0jsir5	196	8	)	)	-RRB-
cord-254895-ym0jsir5	196	9	.	.	.
cord-254895-ym0jsir5	197	1	In	in	IN
cord-254895-ym0jsir5	197	2	two	two	CD
cord-254895-ym0jsir5	197	3	mouse	mouse	NN
cord-254895-ym0jsir5	197	4	models	model	NNS
cord-254895-ym0jsir5	197	5	of	of	IN
cord-254895-ym0jsir5	197	6	local	local	JJ
cord-254895-ym0jsir5	197	7	infection	infection	NN
cord-254895-ym0jsir5	197	8	with	with	IN
cord-254895-ym0jsir5	197	9	HSV-1	hsv-1	NN
cord-254895-ym0jsir5	197	10	(	(	-LRB-
cord-254895-ym0jsir5	197	11	footpad	footpad	NN
cord-254895-ym0jsir5	197	12	or	or	CC
cord-254895-ym0jsir5	197	13	eye	eye	NN
cord-254895-ym0jsir5	197	14	infection	infection	NN
cord-254895-ym0jsir5	197	15	)	)	-RRB-
cord-254895-ym0jsir5	197	16	,	,	,
cord-254895-ym0jsir5	197	17	however	however	RB
cord-254895-ym0jsir5	197	18	,	,	,
cord-254895-ym0jsir5	197	19	we	-PRON-	PRP
cord-254895-ym0jsir5	197	20	did	do	VBD
cord-254895-ym0jsir5	197	21	not	not	RB
cord-254895-ym0jsir5	197	22	find	find	VB
cord-254895-ym0jsir5	197	23	a	a	DT
cord-254895-ym0jsir5	197	24	significant	significant	JJ
cord-254895-ym0jsir5	197	25	difference	difference	NN
cord-254895-ym0jsir5	197	26	in	in	IN
cord-254895-ym0jsir5	197	27	viral	viral	JJ
cord-254895-ym0jsir5	197	28	titers	titer	NNS
cord-254895-ym0jsir5	197	29	between	between	IN
cord-254895-ym0jsir5	197	30	TLR9	TLR9	NNP
cord-254895-ym0jsir5	197	31	À	à	NN
cord-254895-ym0jsir5	197	32	/	/	SYM
cord-254895-ym0jsir5	197	33	À	à	NN
cord-254895-ym0jsir5	197	34	and	and	CC
cord-254895-ym0jsir5	197	35	MyD88	MyD88	NNP
cord-254895-ym0jsir5	197	36	À	à	NN
cord-254895-ym0jsir5	197	37	/	/	SYM
cord-254895-ym0jsir5	197	38	À	à	NN
cord-254895-ym0jsir5	197	39	mice	mouse	NNS
cord-254895-ym0jsir5	197	40	and	and	CC
cord-254895-ym0jsir5	197	41	wildtype	wildtype	NN
cord-254895-ym0jsir5	197	42	mice	mouse	NNS
cord-254895-ym0jsir5	198	1	(	(	-LRB-
cord-254895-ym0jsir5	198	2	Krug	Krug	NNP
cord-254895-ym0jsir5	198	3	et	et	NNP
cord-254895-ym0jsir5	198	4	al	al	NNP
cord-254895-ym0jsir5	198	5	.	.	NNP
cord-254895-ym0jsir5	198	6	,	,	,
cord-254895-ym0jsir5	198	7	2004b	2004b	CD
cord-254895-ym0jsir5	198	8	)	)	-RRB-
cord-254895-ym0jsir5	198	9	.	.	.
cord-254895-ym0jsir5	199	1	The	the	DT
cord-254895-ym0jsir5	199	2	requirement	requirement	NN
cord-254895-ym0jsir5	199	3	for	for	IN
cord-254895-ym0jsir5	199	4	TLR9	TLR9	NNP
cord-254895-ym0jsir5	199	5	in	in	IN
cord-254895-ym0jsir5	199	6	the	the	DT
cord-254895-ym0jsir5	199	7	innate	innate	JJ
cord-254895-ym0jsir5	199	8	immune	immune	JJ
cord-254895-ym0jsir5	199	9	response	response	NN
cord-254895-ym0jsir5	199	10	to	to	IN
cord-254895-ym0jsir5	199	11	herpes	herpes	NN
cord-254895-ym0jsir5	199	12	viruses	virus	NNS
cord-254895-ym0jsir5	199	13	in	in	IN
cord-254895-ym0jsir5	199	14	vivo	vivo	NN
cord-254895-ym0jsir5	199	15	is	be	VBZ
cord-254895-ym0jsir5	199	16	influenced	influence	VBN
cord-254895-ym0jsir5	199	17	by	by	IN
cord-254895-ym0jsir5	199	18	the	the	DT
cord-254895-ym0jsir5	199	19	site	site	NN
cord-254895-ym0jsir5	199	20	of	of	IN
cord-254895-ym0jsir5	199	21	virus	virus	NN
cord-254895-ym0jsir5	199	22	entry	entry	NN
cord-254895-ym0jsir5	199	23	and	and	CC
cord-254895-ym0jsir5	199	24	the	the	DT
cord-254895-ym0jsir5	199	25	recruitment	recruitment	NN
cord-254895-ym0jsir5	199	26	of	of	IN
cord-254895-ym0jsir5	199	27	DC	DC	NNP
cord-254895-ym0jsir5	199	28	subpopulations	subpopulation	NNS
cord-254895-ym0jsir5	199	29	to	to	IN
cord-254895-ym0jsir5	199	30	the	the	DT
cord-254895-ym0jsir5	199	31	infected	infected	JJ
cord-254895-ym0jsir5	199	32	tissue	tissue	NN
cord-254895-ym0jsir5	199	33	.	.	.
cord-254895-ym0jsir5	200	1	All	all	DT
cord-254895-ym0jsir5	200	2	of	of	IN
cord-254895-ym0jsir5	200	3	the	the	DT
cord-254895-ym0jsir5	200	4	described	describe	VBN
cord-254895-ym0jsir5	200	5	in	in	IN
cord-254895-ym0jsir5	200	6	vivo	vivo	NNP
cord-254895-ym0jsir5	200	7	studies	study	NNS
cord-254895-ym0jsir5	200	8	show	show	VBP
cord-254895-ym0jsir5	200	9	that	that	IN
cord-254895-ym0jsir5	200	10	in	in	IN
cord-254895-ym0jsir5	200	11	addition	addition	NN
cord-254895-ym0jsir5	200	12	to	to	IN
cord-254895-ym0jsir5	200	13	TLR9	tlr9	CD
cord-254895-ym0jsir5	200	14	other	other	JJ
cord-254895-ym0jsir5	200	15	pattern	pattern	NN
cord-254895-ym0jsir5	200	16	recognition	recognition	NN
cord-254895-ym0jsir5	200	17	receptors	receptor	NNS
cord-254895-ym0jsir5	200	18	and	and	CC
cord-254895-ym0jsir5	200	19	signaling	signal	VBG
cord-254895-ym0jsir5	200	20	pathways	pathway	NNS
cord-254895-ym0jsir5	200	21	responding	respond	VBG
cord-254895-ym0jsir5	200	22	to	to	IN
cord-254895-ym0jsir5	200	23	herpes	herpes	NN
cord-254895-ym0jsir5	200	24	virus	virus	NN
cord-254895-ym0jsir5	200	25	infection	infection	NN
cord-254895-ym0jsir5	200	26	must	must	MD
cord-254895-ym0jsir5	200	27	exist	exist	VB
cord-254895-ym0jsir5	200	28	,	,	,
cord-254895-ym0jsir5	200	29	which	which	WDT
cord-254895-ym0jsir5	200	30	can	can	MD
cord-254895-ym0jsir5	200	31	partially	partially	RB
cord-254895-ym0jsir5	200	32	compensate	compensate	VB
cord-254895-ym0jsir5	200	33	for	for	IN
cord-254895-ym0jsir5	200	34	the	the	DT
cord-254895-ym0jsir5	200	35	lack	lack	NN
cord-254895-ym0jsir5	200	36	of	of	IN
cord-254895-ym0jsir5	200	37	TLR9	TLR9	NNP
cord-254895-ym0jsir5	200	38	and	and	CC
cord-254895-ym0jsir5	200	39	other	other	JJ
cord-254895-ym0jsir5	200	40	MyD88-dependent	MyD88-dependent	NNP
cord-254895-ym0jsir5	200	41	receptors	receptor	NNS
cord-254895-ym0jsir5	200	42	(	(	-LRB-
cord-254895-ym0jsir5	200	43	Krug	Krug	NNP
cord-254895-ym0jsir5	200	44	et	et	NNP
cord-254895-ym0jsir5	200	45	al	al	NNP
cord-254895-ym0jsir5	200	46	.	.	NNP
cord-254895-ym0jsir5	200	47	,	,	,
cord-254895-ym0jsir5	200	48	2004b	2004b	CD
cord-254895-ym0jsir5	200	49	;	;	:
cord-254895-ym0jsir5	201	1	Hochrein	Hochrein	NNP
cord-254895-ym0jsir5	201	2	et	et	NNP
cord-254895-ym0jsir5	201	3	al	al	NNP
cord-254895-ym0jsir5	201	4	.	.	NNP
cord-254895-ym0jsir5	201	5	,	,	,
cord-254895-ym0jsir5	201	6	2004	2004	CD
cord-254895-ym0jsir5	201	7	;	;	:
cord-254895-ym0jsir5	201	8	Lund	Lund	NNP
cord-254895-ym0jsir5	201	9	et	et	NNP
cord-254895-ym0jsir5	201	10	al	al	NNP
cord-254895-ym0jsir5	201	11	.	.	NNP
cord-254895-ym0jsir5	201	12	,	,	,
cord-254895-ym0jsir5	201	13	2006	2006	CD
cord-254895-ym0jsir5	201	14	)	)	-RRB-
cord-254895-ym0jsir5	201	15	.	.	.
cord-254895-ym0jsir5	202	1	The	the	DT
cord-254895-ym0jsir5	202	2	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	202	3	DNA	dna	NN
cord-254895-ym0jsir5	202	4	receptor	receptor	NN
cord-254895-ym0jsir5	202	5	which	which	WDT
cord-254895-ym0jsir5	202	6	has	have	VBZ
cord-254895-ym0jsir5	202	7	been	be	VBN
cord-254895-ym0jsir5	202	8	described	describe	VBN
cord-254895-ym0jsir5	202	9	recently	recently	RB
cord-254895-ym0jsir5	202	10	(	(	-LRB-
cord-254895-ym0jsir5	202	11	Stetson	Stetson	NNP
cord-254895-ym0jsir5	202	12	and	and	CC
cord-254895-ym0jsir5	202	13	Medzhitov	Medzhitov	NNP
cord-254895-ym0jsir5	202	14	,	,	,
cord-254895-ym0jsir5	202	15	2006	2006	CD
cord-254895-ym0jsir5	202	16	;	;	:
cord-254895-ym0jsir5	202	17	Ishii	Ishii	NNP
cord-254895-ym0jsir5	202	18	et	et	NNP
cord-254895-ym0jsir5	202	19	al	al	NNP
cord-254895-ym0jsir5	202	20	.	.	NNP
cord-254895-ym0jsir5	202	21	,	,	,
cord-254895-ym0jsir5	202	22	2006	2006	CD
cord-254895-ym0jsir5	202	23	;	;	:
cord-254895-ym0jsir5	202	24	Takaoka	Takaoka	NNP
cord-254895-ym0jsir5	202	25	et	et	NNP
cord-254895-ym0jsir5	202	26	al	al	NNP
cord-254895-ym0jsir5	202	27	.	.	NNP
cord-254895-ym0jsir5	202	28	,	,	,
cord-254895-ym0jsir5	202	29	2007	2007	CD
cord-254895-ym0jsir5	202	30	)	)	-RRB-
cord-254895-ym0jsir5	202	31	may	may	MD
cord-254895-ym0jsir5	202	32	also	also	RB
cord-254895-ym0jsir5	202	33	be	be	VB
cord-254895-ym0jsir5	202	34	involved	involve	VBN
cord-254895-ym0jsir5	202	35	in	in	IN
cord-254895-ym0jsir5	202	36	the	the	DT
cord-254895-ym0jsir5	202	37	TLR9independent	TLR9independent	NNP
cord-254895-ym0jsir5	202	38	component	component	NN
cord-254895-ym0jsir5	202	39	of	of	IN
cord-254895-ym0jsir5	202	40	the	the	DT
cord-254895-ym0jsir5	202	41	immune	immune	JJ
cord-254895-ym0jsir5	202	42	response	response	NN
cord-254895-ym0jsir5	202	43	to	to	IN
cord-254895-ym0jsir5	202	44	herpes	herpes	NN
cord-254895-ym0jsir5	202	45	virus	virus	NN
cord-254895-ym0jsir5	202	46	infections	infection	NNS
cord-254895-ym0jsir5	202	47	.	.	.
cord-254895-ym0jsir5	203	1	Toll	toll	NN
cord-254895-ym0jsir5	203	2	-	-	HYPH
cord-254895-ym0jsir5	203	3	like	like	JJ
cord-254895-ym0jsir5	203	4	receptor	receptor	NN
cord-254895-ym0jsir5	203	5	7	7	CD
cord-254895-ym0jsir5	203	6	and	and	CC
cord-254895-ym0jsir5	203	7	8	8	CD
cord-254895-ym0jsir5	203	8	TLR7	TLR7	NNP
cord-254895-ym0jsir5	203	9	and	and	CC
cord-254895-ym0jsir5	203	10	TLR8	TLR8	NNP
cord-254895-ym0jsir5	203	11	are	be	VBP
cord-254895-ym0jsir5	203	12	both	both	DT
cord-254895-ym0jsir5	203	13	located	locate	VBN
cord-254895-ym0jsir5	203	14	on	on	IN
cord-254895-ym0jsir5	203	15	the	the	DT
cord-254895-ym0jsir5	203	16	X	x	NN
cord-254895-ym0jsir5	203	17	chromosome	chromosome	NN
cord-254895-ym0jsir5	203	18	and	and	CC
cord-254895-ym0jsir5	203	19	are	be	VBP
cord-254895-ym0jsir5	203	20	homologous	homologous	JJ
cord-254895-ym0jsir5	203	21	to	to	IN
cord-254895-ym0jsir5	203	22	each	each	DT
cord-254895-ym0jsir5	203	23	other	other	JJ
cord-254895-ym0jsir5	203	24	.	.	.
cord-254895-ym0jsir5	204	1	GU	GU	NNP
cord-254895-ym0jsir5	204	2	-	-	HYPH
cord-254895-ym0jsir5	204	3	rich	rich	JJ
cord-254895-ym0jsir5	204	4	ssRNA	ssrna	NN
cord-254895-ym0jsir5	204	5	sequences	sequence	NNS
cord-254895-ym0jsir5	204	6	of	of	IN
cord-254895-ym0jsir5	204	7	viral	viral	JJ
cord-254895-ym0jsir5	204	8	or	or	CC
cord-254895-ym0jsir5	204	9	host	host	NN
cord-254895-ym0jsir5	204	10	origin	origin	NN
cord-254895-ym0jsir5	204	11	,	,	,
cord-254895-ym0jsir5	204	12	poly	poly	NNP
cord-254895-ym0jsir5	204	13	-	-	HYPH
cord-254895-ym0jsir5	204	14	U	U	NNP
cord-254895-ym0jsir5	204	15	RNA	RNA	NNP
cord-254895-ym0jsir5	204	16	and	and	CC
cord-254895-ym0jsir5	204	17	specific	specific	JJ
cord-254895-ym0jsir5	204	18	siRNA	siRNA	NNP
cord-254895-ym0jsir5	204	19	sequences	sequence	NNS
cord-254895-ym0jsir5	204	20	are	be	VBP
cord-254895-ym0jsir5	204	21	ligands	ligand	NNS
cord-254895-ym0jsir5	204	22	for	for	IN
cord-254895-ym0jsir5	204	23	both	both	DT
cord-254895-ym0jsir5	204	24	receptors	receptor	NNS
cord-254895-ym0jsir5	204	25	,	,	,
cord-254895-ym0jsir5	204	26	whereas	whereas	IN
cord-254895-ym0jsir5	204	27	synthetic	synthetic	JJ
cord-254895-ym0jsir5	204	28	imidazoquinoline	imidazoquinoline	NN
cord-254895-ym0jsir5	204	29	derivatives	derivative	NNS
cord-254895-ym0jsir5	204	30	have	have	VBP
cord-254895-ym0jsir5	204	31	been	be	VBN
cord-254895-ym0jsir5	204	32	designed	design	VBN
cord-254895-ym0jsir5	204	33	to	to	TO
cord-254895-ym0jsir5	204	34	specifically	specifically	RB
cord-254895-ym0jsir5	204	35	activate	activate	VB
cord-254895-ym0jsir5	204	36	TLR7	TLR7	NNP
cord-254895-ym0jsir5	204	37	or	or	CC
cord-254895-ym0jsir5	204	38	TLR8	TLR8	NNP
cord-254895-ym0jsir5	204	39	or	or	CC
cord-254895-ym0jsir5	204	40	both	both	DT
cord-254895-ym0jsir5	204	41	receptors	receptor	NNS
cord-254895-ym0jsir5	204	42	(	(	-LRB-
cord-254895-ym0jsir5	204	43	Heil	Heil	NNP
cord-254895-ym0jsir5	204	44	et	et	NNP
cord-254895-ym0jsir5	204	45	al	al	NNP
cord-254895-ym0jsir5	204	46	.	.	NNP
cord-254895-ym0jsir5	204	47	,	,	,
cord-254895-ym0jsir5	204	48	2004	2004	CD
cord-254895-ym0jsir5	204	49	;	;	:
cord-254895-ym0jsir5	204	50	Hemmi	Hemmi	NNP
cord-254895-ym0jsir5	204	51	et	et	NNP
cord-254895-ym0jsir5	204	52	al	al	NNP
cord-254895-ym0jsir5	204	53	.	.	NNP
cord-254895-ym0jsir5	204	54	,	,	,
cord-254895-ym0jsir5	204	55	2002	2002	CD
cord-254895-ym0jsir5	204	56	;	;	:
cord-254895-ym0jsir5	205	1	Diebold	Diebold	NNP
cord-254895-ym0jsir5	205	2	et	et	FW
cord-254895-ym0jsir5	205	3	al	al	NNP
cord-254895-ym0jsir5	205	4	.	.	NNP
cord-254895-ym0jsir5	205	5	,	,	,
cord-254895-ym0jsir5	205	6	2004	2004	CD
cord-254895-ym0jsir5	206	1	;	;	:
cord-254895-ym0jsir5	206	2	Jurk	Jurk	NNP
cord-254895-ym0jsir5	206	3	et	et	NNP
cord-254895-ym0jsir5	206	4	al	al	NNP
cord-254895-ym0jsir5	206	5	.	.	NNP
cord-254895-ym0jsir5	206	6	,	,	,
cord-254895-ym0jsir5	206	7	2002	2002	CD
cord-254895-ym0jsir5	206	8	;	;	:
cord-254895-ym0jsir5	206	9	Hornung	Hornung	NNP
cord-254895-ym0jsir5	206	10	et	et	NNP
cord-254895-ym0jsir5	206	11	al	al	NNP
cord-254895-ym0jsir5	206	12	.	.	.
cord-254895-ym0jsir5	207	1	,	,	,
cord-254895-ym0jsir5	207	2	2005	2005	CD
cord-254895-ym0jsir5	207	3	;	;	:
cord-254895-ym0jsir5	207	4	Gorden	Gorden	NNP
cord-254895-ym0jsir5	207	5	et	et	NNP
cord-254895-ym0jsir5	207	6	al	al	NNP
cord-254895-ym0jsir5	207	7	.	.	NNP
cord-254895-ym0jsir5	207	8	,	,	,
cord-254895-ym0jsir5	207	9	2005	2005	CD
cord-254895-ym0jsir5	207	10	)	)	-RRB-
cord-254895-ym0jsir5	207	11	.	.	.
cord-254895-ym0jsir5	208	1	TLR7	TLR7	NNP
cord-254895-ym0jsir5	208	2	is	be	VBZ
cord-254895-ym0jsir5	208	3	expressed	express	VBN
cord-254895-ym0jsir5	208	4	in	in	IN
cord-254895-ym0jsir5	208	5	human	human	JJ
cord-254895-ym0jsir5	208	6	and	and	CC
cord-254895-ym0jsir5	208	7	murine	murine	JJ
cord-254895-ym0jsir5	208	8	pDCs	pdcs	NN
cord-254895-ym0jsir5	208	9	,	,	,
cord-254895-ym0jsir5	208	10	conventional	conventional	JJ
cord-254895-ym0jsir5	208	11	DCs	dc	NNS
cord-254895-ym0jsir5	208	12	and	and	CC
cord-254895-ym0jsir5	208	13	B	B	NNP
cord-254895-ym0jsir5	208	14	cells	cell	NNS
cord-254895-ym0jsir5	208	15	,	,	,
cord-254895-ym0jsir5	208	16	whereas	whereas	IN
cord-254895-ym0jsir5	208	17	TLR8	TLR8	NNP
cord-254895-ym0jsir5	208	18	seems	seem	VBZ
cord-254895-ym0jsir5	208	19	to	to	TO
cord-254895-ym0jsir5	208	20	be	be	VB
cord-254895-ym0jsir5	208	21	functional	functional	JJ
cord-254895-ym0jsir5	208	22	mainly	mainly	RB
cord-254895-ym0jsir5	208	23	in	in	IN
cord-254895-ym0jsir5	208	24	human	human	JJ
cord-254895-ym0jsir5	208	25	monocytes	monocyte	NNS
cord-254895-ym0jsir5	208	26	and	and	CC
cord-254895-ym0jsir5	208	27	myeloid	myeloid	JJ
cord-254895-ym0jsir5	208	28	DCs	dc	NNS
cord-254895-ym0jsir5	208	29	.	.	.
cord-254895-ym0jsir5	209	1	The	the	DT
cord-254895-ym0jsir5	209	2	role	role	NN
cord-254895-ym0jsir5	209	3	of	of	IN
cord-254895-ym0jsir5	209	4	TLR8	TLR8	NNP
cord-254895-ym0jsir5	209	5	in	in	IN
cord-254895-ym0jsir5	209	6	the	the	DT
cord-254895-ym0jsir5	209	7	murine	murine	JJ
cord-254895-ym0jsir5	209	8	immune	immune	JJ
cord-254895-ym0jsir5	209	9	system	system	NN
cord-254895-ym0jsir5	209	10	remains	remain	VBZ
cord-254895-ym0jsir5	209	11	to	to	TO
cord-254895-ym0jsir5	209	12	be	be	VB
cord-254895-ym0jsir5	209	13	elucidated	elucidate	VBN
cord-254895-ym0jsir5	209	14	.	.	.
cord-254895-ym0jsir5	210	1	Similar	similar	JJ
cord-254895-ym0jsir5	210	2	to	to	IN
cord-254895-ym0jsir5	210	3	what	what	WP
cord-254895-ym0jsir5	210	4	has	have	VBZ
cord-254895-ym0jsir5	210	5	been	be	VBN
cord-254895-ym0jsir5	210	6	described	describe	VBN
cord-254895-ym0jsir5	210	7	for	for	IN
cord-254895-ym0jsir5	210	8	TLR9	TLR9	NNP
cord-254895-ym0jsir5	210	9	,	,	,
cord-254895-ym0jsir5	210	10	activation	activation	NN
cord-254895-ym0jsir5	210	11	of	of	IN
cord-254895-ym0jsir5	210	12	TLR7	TLR7	NNP
cord-254895-ym0jsir5	210	13	and	and	CC
cord-254895-ym0jsir5	210	14	TLR8	TLR8	NNP
cord-254895-ym0jsir5	210	15	by	by	IN
cord-254895-ym0jsir5	210	16	specific	specific	JJ
cord-254895-ym0jsir5	210	17	ligands	ligand	NNS
cord-254895-ym0jsir5	210	18	occurs	occur	VBZ
cord-254895-ym0jsir5	210	19	in	in	IN
cord-254895-ym0jsir5	210	20	the	the	DT
cord-254895-ym0jsir5	210	21	acidified	acidify	VBN
cord-254895-ym0jsir5	210	22	endosomal	endosomal	NNP
cord-254895-ym0jsir5	210	23	compartment	compartment	NN
cord-254895-ym0jsir5	210	24	.	.	.
cord-254895-ym0jsir5	211	1	The	the	DT
cord-254895-ym0jsir5	211	2	MyD88-dependent	MyD88-dependent	NNP
cord-254895-ym0jsir5	211	3	signal	signal	NN
cord-254895-ym0jsir5	211	4	transduction	transduction	NN
cord-254895-ym0jsir5	211	5	pathway	pathway	NN
cord-254895-ym0jsir5	211	6	downstream	downstream	RB
cord-254895-ym0jsir5	211	7	of	of	IN
cord-254895-ym0jsir5	211	8	TLR7	TLR7	NNP
cord-254895-ym0jsir5	212	1	and	and	CC
cord-254895-ym0jsir5	212	2	8	8	CD
cord-254895-ym0jsir5	212	3	is	be	VBZ
cord-254895-ym0jsir5	212	4	very	very	RB
cord-254895-ym0jsir5	212	5	similar	similar	JJ
cord-254895-ym0jsir5	212	6	to	to	IN
cord-254895-ym0jsir5	212	7	TLR9-mediated	tlr9-mediated	JJ
cord-254895-ym0jsir5	212	8	signaling	signal	VBG
cord-254895-ym0jsir5	212	9	.	.	.
cord-254895-ym0jsir5	213	1	Several	several	JJ
cord-254895-ym0jsir5	213	2	viruses	virus	NNS
cord-254895-ym0jsir5	213	3	are	be	VBP
cord-254895-ym0jsir5	213	4	recognized	recognize	VBN
cord-254895-ym0jsir5	213	5	by	by	IN
cord-254895-ym0jsir5	213	6	pDCs	pDCs	NNP
cord-254895-ym0jsir5	213	7	in	in	IN
cord-254895-ym0jsir5	213	8	a	a	DT
cord-254895-ym0jsir5	213	9	TLR7dependent	TLR7dependent	NNP
cord-254895-ym0jsir5	213	10	manner	manner	NN
cord-254895-ym0jsir5	213	11	including	include	VBG
cord-254895-ym0jsir5	213	12	influenza	influenza	NN
cord-254895-ym0jsir5	213	13	virus	virus	NN
cord-254895-ym0jsir5	213	14	(	(	-LRB-
cord-254895-ym0jsir5	213	15	Diebold	Diebold	NNP
cord-254895-ym0jsir5	213	16	et	et	FW
cord-254895-ym0jsir5	213	17	al	al	NNP
cord-254895-ym0jsir5	213	18	.	.	NNP
cord-254895-ym0jsir5	213	19	,	,	,
cord-254895-ym0jsir5	213	20	2004	2004	CD
cord-254895-ym0jsir5	213	21	;	;	:
cord-254895-ym0jsir5	213	22	Barchet	Barchet	NNP
cord-254895-ym0jsir5	213	23	et	et	NNP
cord-254895-ym0jsir5	213	24	al	al	NNP
cord-254895-ym0jsir5	213	25	.	.	NNP
cord-254895-ym0jsir5	213	26	,	,	,
cord-254895-ym0jsir5	213	27	2005	2005	CD
cord-254895-ym0jsir5	213	28	)	)	-RRB-
cord-254895-ym0jsir5	213	29	,	,	,
cord-254895-ym0jsir5	213	30	Newcastle	Newcastle	NNP
cord-254895-ym0jsir5	213	31	disease	disease	NN
cord-254895-ym0jsir5	213	32	virus	virus	NN
cord-254895-ym0jsir5	213	33	(	(	-LRB-
cord-254895-ym0jsir5	213	34	NDV	NDV	NNP
cord-254895-ym0jsir5	213	35	)	)	-RRB-
cord-254895-ym0jsir5	213	36	,	,	,
cord-254895-ym0jsir5	213	37	vesicular	vesicular	JJ
cord-254895-ym0jsir5	213	38	stomatitis	stomatitis	NN
cord-254895-ym0jsir5	213	39	virus	virus	NN
cord-254895-ym0jsir5	213	40	(	(	-LRB-
cord-254895-ym0jsir5	213	41	VSV	VSV	NNP
cord-254895-ym0jsir5	213	42	)	)	-RRB-
cord-254895-ym0jsir5	214	1	(	(	-LRB-
cord-254895-ym0jsir5	214	2	Lund	Lund	NNP
cord-254895-ym0jsir5	214	3	et	et	NNP
cord-254895-ym0jsir5	214	4	al	al	NNP
cord-254895-ym0jsir5	214	5	.	.	NNP
cord-254895-ym0jsir5	214	6	,	,	,
cord-254895-ym0jsir5	214	7	2004	2004	CD
cord-254895-ym0jsir5	214	8	)	)	-RRB-
cord-254895-ym0jsir5	214	9	,	,	,
cord-254895-ym0jsir5	214	10	coronaviruses	coronaviruse	NNS
cord-254895-ym0jsir5	214	11	(	(	-LRB-
cord-254895-ym0jsir5	214	12	Cervantes-	Cervantes-	VBZ
cord-254895-ym0jsir5	214	13	Barragan	Barragan	NNP
cord-254895-ym0jsir5	214	14	et	et	NNP
cord-254895-ym0jsir5	214	15	al	al	NNP
cord-254895-ym0jsir5	214	16	.	.	NNP
cord-254895-ym0jsir5	214	17	,	,	,
cord-254895-ym0jsir5	214	18	2006	2006	CD
cord-254895-ym0jsir5	214	19	)	)	-RRB-
cord-254895-ym0jsir5	214	20	and	and	CC
cord-254895-ym0jsir5	214	21	RNA	RNA	NNP
cord-254895-ym0jsir5	214	22	viruses	virus	NNS
cord-254895-ym0jsir5	214	23	(	(	-LRB-
cord-254895-ym0jsir5	214	24	Heil	Heil	NNP
cord-254895-ym0jsir5	214	25	et	et	NNP
cord-254895-ym0jsir5	214	26	al	al	NNP
cord-254895-ym0jsir5	214	27	.	.	.
cord-254895-ym0jsir5	215	1	,	,	,
cord-254895-ym0jsir5	215	2	2004	2004	CD
cord-254895-ym0jsir5	215	3	;	;	:
cord-254895-ym0jsir5	215	4	Beignon	Beignon	NNP
cord-254895-ym0jsir5	215	5	et	et	NNP
cord-254895-ym0jsir5	215	6	al	al	NNP
cord-254895-ym0jsir5	215	7	.	.	NNP
cord-254895-ym0jsir5	215	8	,	,	,
cord-254895-ym0jsir5	215	9	2005	2005	CD
cord-254895-ym0jsir5	215	10	)	)	-RRB-
cord-254895-ym0jsir5	215	11	.	.	.
cord-254895-ym0jsir5	216	1	TLR7	TLR7	NNP
cord-254895-ym0jsir5	216	2	does	do	VBZ
cord-254895-ym0jsir5	216	3	not	not	RB
cord-254895-ym0jsir5	216	4	seem	seem	VB
cord-254895-ym0jsir5	216	5	to	to	TO
cord-254895-ym0jsir5	216	6	play	play	VB
cord-254895-ym0jsir5	216	7	an	an	DT
cord-254895-ym0jsir5	216	8	essential	essential	JJ
cord-254895-ym0jsir5	216	9	role	role	NN
cord-254895-ym0jsir5	216	10	in	in	IN
cord-254895-ym0jsir5	216	11	the	the	DT
cord-254895-ym0jsir5	216	12	innate	innate	JJ
cord-254895-ym0jsir5	216	13	immune	immune	JJ
cord-254895-ym0jsir5	216	14	response	response	NN
cord-254895-ym0jsir5	216	15	to	to	IN
cord-254895-ym0jsir5	216	16	RNA	RNA	NNP
cord-254895-ym0jsir5	216	17	virus	virus	NN
cord-254895-ym0jsir5	216	18	infection	infection	NN
cord-254895-ym0jsir5	216	19	in	in	IN
cord-254895-ym0jsir5	216	20	vivo	vivo	NN
cord-254895-ym0jsir5	216	21	.	.	.
cord-254895-ym0jsir5	217	1	We	-PRON-	PRP
cord-254895-ym0jsir5	217	2	could	could	MD
cord-254895-ym0jsir5	217	3	not	not	RB
cord-254895-ym0jsir5	217	4	find	find	VB
cord-254895-ym0jsir5	217	5	a	a	DT
cord-254895-ym0jsir5	217	6	significant	significant	JJ
cord-254895-ym0jsir5	217	7	difference	difference	NN
cord-254895-ym0jsir5	217	8	between	between	IN
cord-254895-ym0jsir5	217	9	MyD88	MyD88	NNP
cord-254895-ym0jsir5	217	10	À	à	NN
cord-254895-ym0jsir5	217	11	/	/	SYM
cord-254895-ym0jsir5	217	12	À	à	NN
cord-254895-ym0jsir5	217	13	and	and	CC
cord-254895-ym0jsir5	217	14	wild	wild	JJ
cord-254895-ym0jsir5	217	15	-	-	HYPH
cord-254895-ym0jsir5	217	16	type	type	NN
cord-254895-ym0jsir5	217	17	mice	mouse	NNS
cord-254895-ym0jsir5	217	18	in	in	IN
cord-254895-ym0jsir5	217	19	the	the	DT
cord-254895-ym0jsir5	217	20	susceptibility	susceptibility	NN
cord-254895-ym0jsir5	217	21	to	to	IN
cord-254895-ym0jsir5	217	22	intranasal	intranasal	NN
cord-254895-ym0jsir5	217	23	influenza	influenza	NN
cord-254895-ym0jsir5	217	24	virus	virus	NN
cord-254895-ym0jsir5	217	25	infection	infection	NN
cord-254895-ym0jsir5	217	26	and	and	CC
cord-254895-ym0jsir5	217	27	type	type	NN
cord-254895-ym0jsir5	218	1	I	-PRON-	PRP
cord-254895-ym0jsir5	218	2	IFN	IFN	NNP
cord-254895-ym0jsir5	218	3	response	response	NN
cord-254895-ym0jsir5	218	4	to	to	IN
cord-254895-ym0jsir5	218	5	intravenously	intravenously	RB
cord-254895-ym0jsir5	218	6	injected	inject	VBN
cord-254895-ym0jsir5	218	7	influenza	influenza	NN
cord-254895-ym0jsir5	218	8	virus	virus	NN
cord-254895-ym0jsir5	218	9	was	be	VBD
cord-254895-ym0jsir5	218	10	only	only	RB
cord-254895-ym0jsir5	218	11	partially	partially	RB
cord-254895-ym0jsir5	218	12	reduced	reduce	VBN
cord-254895-ym0jsir5	218	13	in	in	IN
cord-254895-ym0jsir5	218	14	the	the	DT
cord-254895-ym0jsir5	218	15	MyD88-deficient	MyD88-deficient	NNP
cord-254895-ym0jsir5	218	16	animals	animal	NNS
cord-254895-ym0jsir5	218	17	(	(	-LRB-
cord-254895-ym0jsir5	218	18	Barchet	Barchet	NNP
cord-254895-ym0jsir5	218	19	et	et	NNP
cord-254895-ym0jsir5	218	20	al	al	NNP
cord-254895-ym0jsir5	218	21	.	.	NNP
cord-254895-ym0jsir5	218	22	,	,	,
cord-254895-ym0jsir5	218	23	2005	2005	CD
cord-254895-ym0jsir5	218	24	)	)	-RRB-
cord-254895-ym0jsir5	218	25	.	.	.
cord-254895-ym0jsir5	219	1	At	at	IN
cord-254895-ym0jsir5	219	2	high	high	JJ
cord-254895-ym0jsir5	219	3	viral	viral	JJ
cord-254895-ym0jsir5	219	4	doses	dose	NNS
cord-254895-ym0jsir5	219	5	type	type	NN
cord-254895-ym0jsir5	219	6	I	-PRON-	PRP
cord-254895-ym0jsir5	219	7	IFN	IFN	NNP
cord-254895-ym0jsir5	219	8	response	response	NN
cord-254895-ym0jsir5	219	9	to	to	IN
cord-254895-ym0jsir5	219	10	systemic	systemic	JJ
cord-254895-ym0jsir5	219	11	VSV	VSV	NNP
cord-254895-ym0jsir5	219	12	infection	infection	NN
cord-254895-ym0jsir5	219	13	is	be	VBZ
cord-254895-ym0jsir5	219	14	TLR7dependent	TLR7dependent	NNP
cord-254895-ym0jsir5	219	15	and	and	CC
cord-254895-ym0jsir5	219	16	mediated	mediate	VBN
cord-254895-ym0jsir5	219	17	by	by	IN
cord-254895-ym0jsir5	219	18	pDCs	pDCs	NNP
cord-254895-ym0jsir5	219	19	,	,	,
cord-254895-ym0jsir5	219	20	whereas	whereas	IN
cord-254895-ym0jsir5	219	21	at	at	IN
cord-254895-ym0jsir5	219	22	lower	low	JJR
cord-254895-ym0jsir5	219	23	doses	dose	NNS
cord-254895-ym0jsir5	219	24	TLR7-independent	tlr7-independent	NN
cord-254895-ym0jsir5	219	25	type	type	NN
cord-254895-ym0jsir5	219	26	I	-PRON-	PRP
cord-254895-ym0jsir5	219	27	IFN	IFN	NNP
cord-254895-ym0jsir5	219	28	induction	induction	NN
cord-254895-ym0jsir5	219	29	pathways	pathway	NNS
cord-254895-ym0jsir5	219	30	play	play	VBP
cord-254895-ym0jsir5	219	31	the	the	DT
cord-254895-ym0jsir5	219	32	major	major	JJ
cord-254895-ym0jsir5	219	33	role	role	NN
cord-254895-ym0jsir5	219	34	.	.	.
cord-254895-ym0jsir5	220	1	A	a	DT
cord-254895-ym0jsir5	220	2	recent	recent	JJ
cord-254895-ym0jsir5	220	3	study	study	NN
cord-254895-ym0jsir5	220	4	demonstrates	demonstrate	VBZ
cord-254895-ym0jsir5	220	5	an	an	DT
cord-254895-ym0jsir5	220	6	essential	essential	JJ
cord-254895-ym0jsir5	220	7	function	function	NN
cord-254895-ym0jsir5	220	8	of	of	IN
cord-254895-ym0jsir5	220	9	TLR7	TLR7	NNP
cord-254895-ym0jsir5	220	10	for	for	IN
cord-254895-ym0jsir5	220	11	the	the	DT
cord-254895-ym0jsir5	220	12	innate	innate	JJ
cord-254895-ym0jsir5	220	13	immune	immune	JJ
cord-254895-ym0jsir5	220	14	response	response	NN
cord-254895-ym0jsir5	220	15	to	to	IN
cord-254895-ym0jsir5	220	16	systemic	systemic	JJ
cord-254895-ym0jsir5	220	17	coronavirus	coronavirus	NN
cord-254895-ym0jsir5	220	18	infection	infection	NN
cord-254895-ym0jsir5	220	19	in	in	IN
cord-254895-ym0jsir5	220	20	mice	mouse	NNS
cord-254895-ym0jsir5	221	1	(	(	-LRB-
cord-254895-ym0jsir5	221	2	Cervantes	Cervantes	NNP
cord-254895-ym0jsir5	221	3	-	-	HYPH
cord-254895-ym0jsir5	221	4	Barragan	Barragan	NNP
cord-254895-ym0jsir5	221	5	et	et	NNP
cord-254895-ym0jsir5	221	6	al	al	NNP
cord-254895-ym0jsir5	221	7	.	.	NNP
cord-254895-ym0jsir5	221	8	,	,	,
cord-254895-ym0jsir5	221	9	2006	2006	CD
cord-254895-ym0jsir5	221	10	)	)	-RRB-
cord-254895-ym0jsir5	221	11	.	.	.
cord-254895-ym0jsir5	222	1	pDCs	pDCs	NNP
cord-254895-ym0jsir5	222	2	,	,	,
cord-254895-ym0jsir5	222	3	but	but	CC
cord-254895-ym0jsir5	222	4	not	not	RB
cord-254895-ym0jsir5	222	5	conventional	conventional	JJ
cord-254895-ym0jsir5	222	6	DCs	dc	NNS
cord-254895-ym0jsir5	222	7	are	be	VBP
cord-254895-ym0jsir5	222	8	capable	capable	JJ
cord-254895-ym0jsir5	222	9	of	of	IN
cord-254895-ym0jsir5	222	10	producing	produce	VBG
cord-254895-ym0jsir5	222	11	significant	significant	JJ
cord-254895-ym0jsir5	222	12	amounts	amount	NNS
cord-254895-ym0jsir5	222	13	of	of	IN
cord-254895-ym0jsir5	222	14	type	type	NN
cord-254895-ym0jsir5	223	1	I	-PRON-	PRP
cord-254895-ym0jsir5	223	2	IFN	IFN	NNP
cord-254895-ym0jsir5	223	3	in	in	IN
cord-254895-ym0jsir5	223	4	response	response	NN
cord-254895-ym0jsir5	223	5	to	to	IN
cord-254895-ym0jsir5	223	6	the	the	DT
cord-254895-ym0jsir5	223	7	rapidly	rapidly	RB
cord-254895-ym0jsir5	223	8	replicating	replicate	VBG
cord-254895-ym0jsir5	223	9	coronaviruses	coronaviruse	NNS
cord-254895-ym0jsir5	223	10	and	and	CC
cord-254895-ym0jsir5	223	11	this	this	DT
cord-254895-ym0jsir5	223	12	response	response	NN
cord-254895-ym0jsir5	223	13	is	be	VBZ
cord-254895-ym0jsir5	223	14	entirely	entirely	RB
cord-254895-ym0jsir5	223	15	TLR7-dependent	tlr7-dependent	NN
cord-254895-ym0jsir5	223	16	.	.	.
cord-254895-ym0jsir5	224	1	pDC	pDC	NNP
cord-254895-ym0jsir5	224	2	depletion	depletion	NN
cord-254895-ym0jsir5	224	3	led	lead	VBD
cord-254895-ym0jsir5	224	4	to	to	IN
cord-254895-ym0jsir5	224	5	abrogation	abrogation	NN
cord-254895-ym0jsir5	224	6	of	of	IN
cord-254895-ym0jsir5	224	7	type	type	NN
cord-254895-ym0jsir5	225	1	I	-PRON-	PRP
cord-254895-ym0jsir5	225	2	IFN	IFN	NNP
cord-254895-ym0jsir5	225	3	response	response	NN
cord-254895-ym0jsir5	225	4	and	and	CC
cord-254895-ym0jsir5	225	5	increased	increase	VBN
cord-254895-ym0jsir5	225	6	disease	disease	NN
cord-254895-ym0jsir5	225	7	severity	severity	NN
cord-254895-ym0jsir5	225	8	(	(	-LRB-
cord-254895-ym0jsir5	225	9	Cervantes-	Cervantes-	VBZ
cord-254895-ym0jsir5	225	10	Barragan	Barragan	NNP
cord-254895-ym0jsir5	225	11	et	et	NNP
cord-254895-ym0jsir5	225	12	al	al	NNP
cord-254895-ym0jsir5	225	13	.	.	NNP
cord-254895-ym0jsir5	225	14	,	,	,
cord-254895-ym0jsir5	225	15	2006	2006	CD
cord-254895-ym0jsir5	225	16	)	)	-RRB-
cord-254895-ym0jsir5	225	17	.	.	.
cord-254895-ym0jsir5	226	1	It	-PRON-	PRP
cord-254895-ym0jsir5	226	2	can	can	MD
cord-254895-ym0jsir5	226	3	be	be	VB
cord-254895-ym0jsir5	226	4	concluded	conclude	VBN
cord-254895-ym0jsir5	226	5	that	that	IN
cord-254895-ym0jsir5	226	6	TLR7	TLR7	NNP
cord-254895-ym0jsir5	226	7	(	(	-LRB-
cord-254895-ym0jsir5	226	8	and	and	CC
cord-254895-ym0jsir5	226	9	possibly	possibly	RB
cord-254895-ym0jsir5	226	10	TLR8	TLR8	NNP
cord-254895-ym0jsir5	226	11	in	in	IN
cord-254895-ym0jsir5	226	12	the	the	DT
cord-254895-ym0jsir5	226	13	human	human	JJ
cord-254895-ym0jsir5	226	14	system	system	NN
cord-254895-ym0jsir5	226	15	)	)	-RRB-
cord-254895-ym0jsir5	226	16	contribute	contribute	VB
cord-254895-ym0jsir5	226	17	to	to	IN
cord-254895-ym0jsir5	226	18	the	the	DT
cord-254895-ym0jsir5	226	19	initiation	initiation	NN
cord-254895-ym0jsir5	226	20	of	of	IN
cord-254895-ym0jsir5	226	21	the	the	DT
cord-254895-ym0jsir5	226	22	antiviral	antiviral	JJ
cord-254895-ym0jsir5	226	23	immune	immune	JJ
cord-254895-ym0jsir5	226	24	response	response	NN
cord-254895-ym0jsir5	226	25	against	against	IN
cord-254895-ym0jsir5	226	26	viruses	virus	NNS
cord-254895-ym0jsir5	226	27	which	which	WDT
cord-254895-ym0jsir5	226	28	specifically	specifically	RB
cord-254895-ym0jsir5	226	29	target	target	VBP
cord-254895-ym0jsir5	226	30	pDCs	pDCs	NNP
cord-254895-ym0jsir5	226	31	.	.	.
cord-254895-ym0jsir5	227	1	In	in	IN
cord-254895-ym0jsir5	227	2	addition	addition	NN
cord-254895-ym0jsir5	227	3	the	the	DT
cord-254895-ym0jsir5	227	4	ubiquitously	ubiquitously	RB
cord-254895-ym0jsir5	227	5	expressed	express	VBN
cord-254895-ym0jsir5	227	6	RNA	RNA	NNP
cord-254895-ym0jsir5	227	7	helicases	helicase	NNS
cord-254895-ym0jsir5	227	8	provide	provide	VBP
cord-254895-ym0jsir5	227	9	protection	protection	NN
cord-254895-ym0jsir5	227	10	against	against	IN
cord-254895-ym0jsir5	227	11	RNA	RNA	NNP
cord-254895-ym0jsir5	227	12	viruses	virus	NNS
cord-254895-ym0jsir5	227	13	in	in	IN
cord-254895-ym0jsir5	227	14	all	all	DT
cord-254895-ym0jsir5	227	15	cell	cell	NN
cord-254895-ym0jsir5	227	16	types	type	NNS
cord-254895-ym0jsir5	227	17	(	(	-LRB-
cord-254895-ym0jsir5	227	18	see	see	VB
cord-254895-ym0jsir5	227	19	below	below	RB
cord-254895-ym0jsir5	227	20	)	)	-RRB-
cord-254895-ym0jsir5	227	21	.	.	.
cord-254895-ym0jsir5	228	1	Depending	depend	VBG
cord-254895-ym0jsir5	228	2	on	on	IN
cord-254895-ym0jsir5	228	3	the	the	DT
cord-254895-ym0jsir5	228	4	route	route	NN
cord-254895-ym0jsir5	228	5	and	and	CC
cord-254895-ym0jsir5	228	6	kinetics	kinetic	NNS
cord-254895-ym0jsir5	228	7	of	of	IN
cord-254895-ym0jsir5	228	8	infection	infection	NN
cord-254895-ym0jsir5	228	9	,	,	,
cord-254895-ym0jsir5	228	10	cellular	cellular	JJ
cord-254895-ym0jsir5	228	11	tropism	tropism	NN
cord-254895-ym0jsir5	228	12	,	,	,
cord-254895-ym0jsir5	228	13	viral	viral	JJ
cord-254895-ym0jsir5	228	14	entry	entry	NN
cord-254895-ym0jsir5	228	15	and	and	CC
cord-254895-ym0jsir5	228	16	replication	replication	NN
cord-254895-ym0jsir5	228	17	as	as	RB
cord-254895-ym0jsir5	228	18	well	well	RB
cord-254895-ym0jsir5	228	19	as	as	IN
cord-254895-ym0jsir5	228	20	immune	immune	JJ
cord-254895-ym0jsir5	228	21	evasion	evasion	NN
cord-254895-ym0jsir5	228	22	mechanisms	mechanism	NNS
cord-254895-ym0jsir5	228	23	of	of	IN
cord-254895-ym0jsir5	228	24	individual	individual	JJ
cord-254895-ym0jsir5	228	25	virus	virus	NN
cord-254895-ym0jsir5	228	26	strains	strain	VBZ
cord-254895-ym0jsir5	228	27	one	one	CD
cord-254895-ym0jsir5	228	28	or	or	CC
cord-254895-ym0jsir5	228	29	the	the	DT
cord-254895-ym0jsir5	228	30	other	other	JJ
cord-254895-ym0jsir5	228	31	viral	viral	JJ
cord-254895-ym0jsir5	228	32	RNA	RNA	NNP
cord-254895-ym0jsir5	228	33	recognition	recognition	NN
cord-254895-ym0jsir5	228	34	pathway	pathway	NN
cord-254895-ym0jsir5	228	35	may	may	MD
cord-254895-ym0jsir5	228	36	dominate	dominate	VB
cord-254895-ym0jsir5	228	37	the	the	DT
cord-254895-ym0jsir5	228	38	innate	innate	JJ
cord-254895-ym0jsir5	228	39	antiviral	antiviral	JJ
cord-254895-ym0jsir5	228	40	immune	immune	JJ
cord-254895-ym0jsir5	228	41	response	response	NN
cord-254895-ym0jsir5	228	42	in	in	IN
cord-254895-ym0jsir5	228	43	vivo	vivo	NNP
cord-254895-ym0jsir5	228	44	.	.	.
cord-254895-ym0jsir5	229	1	As	as	IN
cord-254895-ym0jsir5	229	2	suggested	suggest	VBN
cord-254895-ym0jsir5	229	3	by	by	IN
cord-254895-ym0jsir5	229	4	the	the	DT
cord-254895-ym0jsir5	229	5	murine	murine	NN
cord-254895-ym0jsir5	229	6	in	in	IN
cord-254895-ym0jsir5	229	7	vivo	vivo	NNP
cord-254895-ym0jsir5	229	8	studies	study	NNS
cord-254895-ym0jsir5	229	9	there	there	EX
cord-254895-ym0jsir5	229	10	is	be	VBZ
cord-254895-ym0jsir5	229	11	considerable	considerable	JJ
cord-254895-ym0jsir5	229	12	redundancy	redundancy	NN
cord-254895-ym0jsir5	229	13	in	in	IN
cord-254895-ym0jsir5	229	14	TLR	tlr	NN
cord-254895-ym0jsir5	229	15	-	-	HYPH
cord-254895-ym0jsir5	229	16	dependent	dependent	JJ
cord-254895-ym0jsir5	229	17	and	and	CC
cord-254895-ym0jsir5	229	18	TLR	tlr	NN
cord-254895-ym0jsir5	229	19	-	-	HYPH
cord-254895-ym0jsir5	229	20	independent	independent	JJ
cord-254895-ym0jsir5	229	21	viral	viral	JJ
cord-254895-ym0jsir5	229	22	pattern	pattern	NN
cord-254895-ym0jsir5	229	23	recognition	recognition	NN
cord-254895-ym0jsir5	229	24	mechanisms	mechanism	NNS
cord-254895-ym0jsir5	229	25	also	also	RB
cord-254895-ym0jsir5	229	26	in	in	IN
cord-254895-ym0jsir5	229	27	the	the	DT
cord-254895-ym0jsir5	229	28	human	human	JJ
cord-254895-ym0jsir5	229	29	system	system	NN
cord-254895-ym0jsir5	229	30	.	.	.
cord-254895-ym0jsir5	230	1	IRAK-4-deficient	IRAK-4-deficient	NNP
cord-254895-ym0jsir5	231	1	patients	patient	NNS
cord-254895-ym0jsir5	231	2	are	be	VBP
cord-254895-ym0jsir5	231	3	prone	prone	JJ
cord-254895-ym0jsir5	231	4	to	to	IN
cord-254895-ym0jsir5	231	5	invasive	invasive	JJ
cord-254895-ym0jsir5	231	6	infection	infection	NN
cord-254895-ym0jsir5	231	7	with	with	IN
cord-254895-ym0jsir5	231	8	pneumococci	pneumococcus	NNS
cord-254895-ym0jsir5	231	9	,	,	,
cord-254895-ym0jsir5	231	10	but	but	CC
cord-254895-ym0jsir5	231	11	are	be	VBP
cord-254895-ym0jsir5	231	12	resistant	resistant	JJ
cord-254895-ym0jsir5	231	13	to	to	IN
cord-254895-ym0jsir5	231	14	natural	natural	JJ
cord-254895-ym0jsir5	231	15	viral	viral	JJ
cord-254895-ym0jsir5	231	16	infection	infection	NN
cord-254895-ym0jsir5	231	17	(	(	-LRB-
cord-254895-ym0jsir5	231	18	Picard	Picard	NNP
cord-254895-ym0jsir5	231	19	et	et	NNP
cord-254895-ym0jsir5	231	20	al	al	NNP
cord-254895-ym0jsir5	231	21	.	.	NNP
cord-254895-ym0jsir5	231	22	,	,	,
cord-254895-ym0jsir5	231	23	2003	2003	CD
cord-254895-ym0jsir5	231	24	)	)	-RRB-
cord-254895-ym0jsir5	231	25	.	.	.
cord-254895-ym0jsir5	232	1	IRAK4-deficient	irak4-deficient	XX
cord-254895-ym0jsir5	233	1	PBMC	PBMC	NNS
cord-254895-ym0jsir5	233	2	do	do	VBP
cord-254895-ym0jsir5	233	3	not	not	RB
cord-254895-ym0jsir5	233	4	respond	respond	VB
cord-254895-ym0jsir5	233	5	to	to	IN
cord-254895-ym0jsir5	233	6	any	any	DT
cord-254895-ym0jsir5	233	7	of	of	IN
cord-254895-ym0jsir5	233	8	the	the	DT
cord-254895-ym0jsir5	233	9	MyD88-dependent	MyD88-dependent	NNP
cord-254895-ym0jsir5	233	10	TLR	TLR	NNP
cord-254895-ym0jsir5	233	11	ligands	ligand	NNS
cord-254895-ym0jsir5	233	12	,	,	,
cord-254895-ym0jsir5	233	13	but	but	CC
cord-254895-ym0jsir5	233	14	are	be	VBP
cord-254895-ym0jsir5	233	15	capable	capable	JJ
cord-254895-ym0jsir5	233	16	of	of	IN
cord-254895-ym0jsir5	233	17	type	type	NN
cord-254895-ym0jsir5	234	1	I	-PRON-	PRP
cord-254895-ym0jsir5	234	2	IFN	IFN	NNP
cord-254895-ym0jsir5	234	3	production	production	NN
cord-254895-ym0jsir5	234	4	in	in	IN
cord-254895-ym0jsir5	234	5	response	response	NN
cord-254895-ym0jsir5	234	6	to	to	IN
cord-254895-ym0jsir5	234	7	many	many	JJ
cord-254895-ym0jsir5	234	8	DNA	DNA	NNP
cord-254895-ym0jsir5	234	9	and	and	CC
cord-254895-ym0jsir5	234	10	RNA	RNA	NNP
cord-254895-ym0jsir5	234	11	viruses	virus	NNS
cord-254895-ym0jsir5	234	12	.	.	.
cord-254895-ym0jsir5	235	1	There	there	EX
cord-254895-ym0jsir5	235	2	also	also	RB
cord-254895-ym0jsir5	235	3	seems	seem	VBZ
cord-254895-ym0jsir5	235	4	to	to	TO
cord-254895-ym0jsir5	235	5	be	be	VB
cord-254895-ym0jsir5	235	6	considerable	considerable	JJ
cord-254895-ym0jsir5	235	7	redundancy	redundancy	NN
cord-254895-ym0jsir5	235	8	between	between	IN
cord-254895-ym0jsir5	235	9	different	different	JJ
cord-254895-ym0jsir5	235	10	TLRs	tlr	NNS
cord-254895-ym0jsir5	235	11	,	,	,
cord-254895-ym0jsir5	235	12	because	because	IN
cord-254895-ym0jsir5	235	13	in	in	IN
cord-254895-ym0jsir5	235	14	contrast	contrast	NN
cord-254895-ym0jsir5	235	15	to	to	IN
cord-254895-ym0jsir5	235	16	the	the	DT
cord-254895-ym0jsir5	235	17	IRAK4-deficient	IRAK4-deficient	NNP
cord-254895-ym0jsir5	235	18	patients	patient	NNS
cord-254895-ym0jsir5	235	19	,	,	,
cord-254895-ym0jsir5	235	20	which	which	WDT
cord-254895-ym0jsir5	235	21	show	show	VBP
cord-254895-ym0jsir5	235	22	no	no	DT
cord-254895-ym0jsir5	235	23	significant	significant	JJ
cord-254895-ym0jsir5	235	24	defects	defect	NNS
cord-254895-ym0jsir5	235	25	in	in	IN
cord-254895-ym0jsir5	235	26	antiviral	antiviral	JJ
cord-254895-ym0jsir5	235	27	responses	response	NNS
cord-254895-ym0jsir5	235	28	(	(	-LRB-
cord-254895-ym0jsir5	235	29	Picard	Picard	NNP
cord-254895-ym0jsir5	235	30	et	et	NNP
cord-254895-ym0jsir5	235	31	al	al	NNP
cord-254895-ym0jsir5	235	32	.	.	NNP
cord-254895-ym0jsir5	235	33	,	,	,
cord-254895-ym0jsir5	235	34	2003	2003	CD
cord-254895-ym0jsir5	235	35	)	)	-RRB-
cord-254895-ym0jsir5	235	36	,	,	,
cord-254895-ym0jsir5	235	37	individuals	individual	NNS
cord-254895-ym0jsir5	235	38	with	with	IN
cord-254895-ym0jsir5	235	39	autosomal	autosomal	JJ
cord-254895-ym0jsir5	235	40	recessive	recessive	JJ
cord-254895-ym0jsir5	235	41	deficiency	deficiency	NN
cord-254895-ym0jsir5	235	42	in	in	IN
cord-254895-ym0jsir5	235	43	the	the	DT
cord-254895-ym0jsir5	235	44	intracellular	intracellular	JJ
cord-254895-ym0jsir5	235	45	protein	protein	NN
cord-254895-ym0jsir5	235	46	Unc-93b	Unc-93b	NNP
cord-254895-ym0jsir5	235	47	have	have	VBP
cord-254895-ym0jsir5	235	48	an	an	DT
cord-254895-ym0jsir5	235	49	impaired	impaired	JJ
cord-254895-ym0jsir5	235	50	antiviral	antiviral	JJ
cord-254895-ym0jsir5	235	51	type	type	NN
cord-254895-ym0jsir5	236	1	I	-PRON-	PRP
cord-254895-ym0jsir5	236	2	IFN	IFN	NNP
cord-254895-ym0jsir5	236	3	response	response	NN
cord-254895-ym0jsir5	236	4	and	and	CC
cord-254895-ym0jsir5	236	5	are	be	VBP
cord-254895-ym0jsir5	236	6	susceptible	susceptible	JJ
cord-254895-ym0jsir5	236	7	to	to	IN
cord-254895-ym0jsir5	236	8	HSV-1	hsv-1	NN
cord-254895-ym0jsir5	236	9	encephalitis	encephalitis	JJ
cord-254895-ym0jsir5	236	10	(	(	-LRB-
cord-254895-ym0jsir5	236	11	Casrouge	Casrouge	NNP
cord-254895-ym0jsir5	236	12	et	et	NNP
cord-254895-ym0jsir5	236	13	al	al	NNP
cord-254895-ym0jsir5	236	14	.	.	NNP
cord-254895-ym0jsir5	236	15	,	,	,
cord-254895-ym0jsir5	236	16	2006	2006	CD
cord-254895-ym0jsir5	236	17	)	)	-RRB-
cord-254895-ym0jsir5	236	18	.	.	.
cord-254895-ym0jsir5	237	1	Unc-93b	unc-93b	JJ
cord-254895-ym0jsir5	237	2	-	-	HYPH
cord-254895-ym0jsir5	237	3	deficiency	deficiency	NN
cord-254895-ym0jsir5	237	4	prevents	prevent	VBZ
cord-254895-ym0jsir5	237	5	signaling	signal	VBG
cord-254895-ym0jsir5	237	6	in	in	IN
cord-254895-ym0jsir5	237	7	response	response	NN
cord-254895-ym0jsir5	237	8	to	to	IN
cord-254895-ym0jsir5	237	9	ligands	ligand	NNS
cord-254895-ym0jsir5	237	10	of	of	IN
cord-254895-ym0jsir5	237	11	the	the	DT
cord-254895-ym0jsir5	237	12	endosomally	endosomally	RB
cord-254895-ym0jsir5	237	13	localized	localize	VBN
cord-254895-ym0jsir5	237	14	TLR3	TLR3	NNP
cord-254895-ym0jsir5	237	15	,	,	,
cord-254895-ym0jsir5	237	16	TLR7	TLR7	NNP
cord-254895-ym0jsir5	237	17	,	,	,
cord-254895-ym0jsir5	237	18	TLR8	TLR8	NNP
cord-254895-ym0jsir5	237	19	and	and	CC
cord-254895-ym0jsir5	237	20	TLR9	TLR9	NNP
cord-254895-ym0jsir5	237	21	.	.	.
cord-254895-ym0jsir5	238	1	In	in	IN
cord-254895-ym0jsir5	238	2	addition	addition	NN
cord-254895-ym0jsir5	238	3	,	,	,
cord-254895-ym0jsir5	238	4	the	the	DT
cord-254895-ym0jsir5	238	5	Unc-93b	Unc-93b	NNP
cord-254895-ym0jsir5	238	6	protein	protein	NN
cord-254895-ym0jsir5	238	7	,	,	,
cord-254895-ym0jsir5	238	8	which	which	WDT
cord-254895-ym0jsir5	238	9	is	be	VBZ
cord-254895-ym0jsir5	238	10	localized	localize	VBN
cord-254895-ym0jsir5	238	11	in	in	IN
cord-254895-ym0jsir5	238	12	the	the	DT
cord-254895-ym0jsir5	238	13	endoplasmic	endoplasmic	NN
cord-254895-ym0jsir5	238	14	reticulum	reticulum	NN
cord-254895-ym0jsir5	238	15	,	,	,
cord-254895-ym0jsir5	238	16	is	be	VBZ
cord-254895-ym0jsir5	238	17	required	require	VBN
cord-254895-ym0jsir5	238	18	for	for	IN
cord-254895-ym0jsir5	238	19	efficient	efficient	JJ
cord-254895-ym0jsir5	238	20	crosspresentation	crosspresentation	NN
cord-254895-ym0jsir5	238	21	and	and	CC
cord-254895-ym0jsir5	238	22	MHC	MHC	NNP
cord-254895-ym0jsir5	238	23	class	class	NN
cord-254895-ym0jsir5	238	24	II	II	NNP
cord-254895-ym0jsir5	238	25	presentation	presentation	NN
cord-254895-ym0jsir5	238	26	of	of	IN
cord-254895-ym0jsir5	238	27	exogenous	exogenous	JJ
cord-254895-ym0jsir5	238	28	antigens	antigen	NNS
cord-254895-ym0jsir5	238	29	.	.	.
cord-254895-ym0jsir5	239	1	Therefore	therefore	RB
cord-254895-ym0jsir5	239	2	,	,	,
cord-254895-ym0jsir5	239	3	Unc-93b	unc-93b	NN
cord-254895-ym0jsir5	239	4	-	-	HYPH
cord-254895-ym0jsir5	239	5	deficiency	deficiency	NN
cord-254895-ym0jsir5	239	6	may	may	MD
cord-254895-ym0jsir5	239	7	affect	affect	VB
cord-254895-ym0jsir5	239	8	innate	innate	JJ
cord-254895-ym0jsir5	239	9	and	and	CC
cord-254895-ym0jsir5	239	10	adaptive	adaptive	JJ
cord-254895-ym0jsir5	239	11	antiviral	antiviral	JJ
cord-254895-ym0jsir5	239	12	immune	immune	JJ
cord-254895-ym0jsir5	239	13	responses	response	NNS
cord-254895-ym0jsir5	239	14	at	at	IN
cord-254895-ym0jsir5	239	15	the	the	DT
cord-254895-ym0jsir5	239	16	same	same	JJ
cord-254895-ym0jsir5	239	17	time	time	NN
cord-254895-ym0jsir5	239	18	.	.	.
cord-254895-ym0jsir5	240	1	No	no	DT
cord-254895-ym0jsir5	240	2	human	human	JJ
cord-254895-ym0jsir5	240	3	deficiencies	deficiency	NNS
cord-254895-ym0jsir5	240	4	or	or	CC
cord-254895-ym0jsir5	240	5	mutation	mutation	NN
cord-254895-ym0jsir5	240	6	in	in	IN
cord-254895-ym0jsir5	240	7	the	the	DT
cord-254895-ym0jsir5	240	8	RIG	RIG	NNP
cord-254895-ym0jsir5	240	9	-	-	HYPH
cord-254895-ym0jsir5	240	10	I/	I/	NNP
cord-254895-ym0jsir5	240	11	MDA5	mda5	JJ
cord-254895-ym0jsir5	240	12	pathway	pathway	NN
cord-254895-ym0jsir5	240	13	of	of	IN
cord-254895-ym0jsir5	240	14	RNA	RNA	NNP
cord-254895-ym0jsir5	240	15	virus	virus	NN
cord-254895-ym0jsir5	240	16	recognition	recognition	NN
cord-254895-ym0jsir5	240	17	have	have	VBP
cord-254895-ym0jsir5	240	18	been	be	VBN
cord-254895-ym0jsir5	240	19	described	describe	VBN
cord-254895-ym0jsir5	240	20	so	so	RB
cord-254895-ym0jsir5	240	21	far	far	RB
cord-254895-ym0jsir5	240	22	.	.	.
cord-254895-ym0jsir5	241	1	However	however	RB
cord-254895-ym0jsir5	241	2	,	,	,
cord-254895-ym0jsir5	241	3	the	the	DT
cord-254895-ym0jsir5	241	4	critical	critical	JJ
cord-254895-ym0jsir5	241	5	role	role	NN
cord-254895-ym0jsir5	241	6	of	of	IN
cord-254895-ym0jsir5	241	7	this	this	DT
cord-254895-ym0jsir5	241	8	major	major	JJ
cord-254895-ym0jsir5	241	9	pathway	pathway	NN
cord-254895-ym0jsir5	241	10	for	for	IN
cord-254895-ym0jsir5	241	11	innate	innate	JJ
cord-254895-ym0jsir5	241	12	antiviral	antiviral	JJ
cord-254895-ym0jsir5	241	13	immune	immune	JJ
cord-254895-ym0jsir5	241	14	responses	response	NNS
cord-254895-ym0jsir5	241	15	in	in	IN
cord-254895-ym0jsir5	241	16	humans	human	NNS
cord-254895-ym0jsir5	241	17	is	be	VBZ
cord-254895-ym0jsir5	241	18	greatly	greatly	RB
cord-254895-ym0jsir5	241	19	supported	support	VBN
cord-254895-ym0jsir5	241	20	by	by	IN
cord-254895-ym0jsir5	241	21	the	the	DT
cord-254895-ym0jsir5	241	22	existence	existence	NN
cord-254895-ym0jsir5	241	23	of	of	IN
cord-254895-ym0jsir5	241	24	viral	viral	JJ
cord-254895-ym0jsir5	241	25	immune	immune	JJ
cord-254895-ym0jsir5	241	26	evasion	evasion	NN
cord-254895-ym0jsir5	241	27	strategies	strategy	NNS
cord-254895-ym0jsir5	241	28	,	,	,
cord-254895-ym0jsir5	241	29	which	which	WDT
cord-254895-ym0jsir5	241	30	,	,	,
cord-254895-ym0jsir5	241	31	for	for	IN
cord-254895-ym0jsir5	241	32	example	example	NN
cord-254895-ym0jsir5	241	33	,	,	,
cord-254895-ym0jsir5	241	34	are	be	VBP
cord-254895-ym0jsir5	241	35	employed	employ	VBN
cord-254895-ym0jsir5	241	36	by	by	IN
cord-254895-ym0jsir5	241	37	hepatitis	hepatitis	NN
cord-254895-ym0jsir5	241	38	C	C	NNP
cord-254895-ym0jsir5	241	39	virus	virus	NN
cord-254895-ym0jsir5	241	40	and	and	CC
cord-254895-ym0jsir5	241	41	paramyxoviruses	paramyxovirus	NNS
cord-254895-ym0jsir5	241	42	and	and	CC
cord-254895-ym0jsir5	241	43	are	be	VBP
cord-254895-ym0jsir5	241	44	directed	direct	VBN
cord-254895-ym0jsir5	241	45	against	against	IN
cord-254895-ym0jsir5	241	46	several	several	JJ
cord-254895-ym0jsir5	241	47	signaling	signal	VBG
cord-254895-ym0jsir5	241	48	molecules	molecule	NNS
cord-254895-ym0jsir5	241	49	in	in	IN
cord-254895-ym0jsir5	241	50	this	this	DT
cord-254895-ym0jsir5	241	51	pathway	pathway	NN
cord-254895-ym0jsir5	241	52	(	(	-LRB-
cord-254895-ym0jsir5	241	53	see	see	VB
cord-254895-ym0jsir5	241	54	below	below	RB
cord-254895-ym0jsir5	241	55	)	)	-RRB-
cord-254895-ym0jsir5	241	56	.	.	.
cord-254895-ym0jsir5	242	1	In	in	IN
cord-254895-ym0jsir5	242	2	addition	addition	NN
cord-254895-ym0jsir5	242	3	to	to	IN
cord-254895-ym0jsir5	242	4	the	the	DT
cord-254895-ym0jsir5	242	5	TLRs	TLRs	NNPS
cord-254895-ym0jsir5	242	6	,	,	,
cord-254895-ym0jsir5	242	7	a	a	DT
cord-254895-ym0jsir5	242	8	new	new	JJ
cord-254895-ym0jsir5	242	9	family	family	NN
cord-254895-ym0jsir5	242	10	of	of	IN
cord-254895-ym0jsir5	242	11	viral	viral	JJ
cord-254895-ym0jsir5	242	12	pattern	pattern	NN
cord-254895-ym0jsir5	242	13	recognition	recognition	NN
cord-254895-ym0jsir5	242	14	receptors	receptor	NNS
cord-254895-ym0jsir5	242	15	consisting	consist	VBG
cord-254895-ym0jsir5	242	16	of	of	IN
cord-254895-ym0jsir5	242	17	RNA	RNA	NNP
cord-254895-ym0jsir5	242	18	helicases	helicase	NNS
cord-254895-ym0jsir5	242	19	retinoic	retinoic	JJ
cord-254895-ym0jsir5	242	20	acid	acid	NN
cord-254895-ym0jsir5	242	21	inducible	inducible	JJ
cord-254895-ym0jsir5	242	22	gene	gene	NN
cord-254895-ym0jsir5	243	1	I	-PRON-	PRP
cord-254895-ym0jsir5	244	1	(	(	-LRB-
cord-254895-ym0jsir5	244	2	RIG	rig	NN
cord-254895-ym0jsir5	244	3	-	-	HYPH
cord-254895-ym0jsir5	244	4	I	I	NNP
cord-254895-ym0jsir5	244	5	)	)	-RRB-
cord-254895-ym0jsir5	244	6	,	,	,
cord-254895-ym0jsir5	244	7	melanoma	melanoma	NN
cord-254895-ym0jsir5	244	8	differentiation	differentiation	NN
cord-254895-ym0jsir5	244	9	antigen	antigen	NNP
cord-254895-ym0jsir5	244	10	5	5	CD
cord-254895-ym0jsir5	244	11	(	(	-LRB-
cord-254895-ym0jsir5	244	12	MDA5	MDA5	NNP
cord-254895-ym0jsir5	244	13	)	)	-RRB-
cord-254895-ym0jsir5	244	14	and	and	CC
cord-254895-ym0jsir5	244	15	laboratory	laboratory	NN
cord-254895-ym0jsir5	244	16	of	of	IN
cord-254895-ym0jsir5	244	17	genetics	genetic	NNS
cord-254895-ym0jsir5	244	18	and	and	CC
cord-254895-ym0jsir5	244	19	physiology	physiology	NN
cord-254895-ym0jsir5	244	20	2	2	CD
cord-254895-ym0jsir5	245	1	(	(	-LRB-
cord-254895-ym0jsir5	245	2	LGP2	LGP2	NNP
cord-254895-ym0jsir5	245	3	)	)	-RRB-
cord-254895-ym0jsir5	245	4	-was	-wa	VBD
cord-254895-ym0jsir5	245	5	discovered	discover	VBN
cord-254895-ym0jsir5	245	6	and	and	CC
cord-254895-ym0jsir5	245	7	characterized	characterize	VBN
cord-254895-ym0jsir5	245	8	in	in	IN
cord-254895-ym0jsir5	245	9	the	the	DT
cord-254895-ym0jsir5	245	10	last	last	JJ
cord-254895-ym0jsir5	245	11	3	3	CD
cord-254895-ym0jsir5	245	12	years	year	NNS
cord-254895-ym0jsir5	245	13	.	.	.
cord-254895-ym0jsir5	246	1	These	these	DT
cord-254895-ym0jsir5	246	2	molecules	molecule	NNS
cord-254895-ym0jsir5	246	3	,	,	,
cord-254895-ym0jsir5	246	4	which	which	WDT
cord-254895-ym0jsir5	246	5	are	be	VBP
cord-254895-ym0jsir5	246	6	localized	localize	VBN
cord-254895-ym0jsir5	246	7	in	in	IN
cord-254895-ym0jsir5	246	8	the	the	DT
cord-254895-ym0jsir5	246	9	cytosol	cytosol	NN
cord-254895-ym0jsir5	246	10	,	,	,
cord-254895-ym0jsir5	246	11	bind	bind	VB
cord-254895-ym0jsir5	246	12	specific	specific	JJ
cord-254895-ym0jsir5	246	13	RNA	RNA	NNP
cord-254895-ym0jsir5	246	14	molecules	molecule	NNS
cord-254895-ym0jsir5	246	15	derived	derive	VBN
cord-254895-ym0jsir5	246	16	from	from	IN
cord-254895-ym0jsir5	246	17	the	the	DT
cord-254895-ym0jsir5	246	18	genome	genome	NN
cord-254895-ym0jsir5	246	19	of	of	IN
cord-254895-ym0jsir5	246	20	different	different	JJ
cord-254895-ym0jsir5	246	21	RNA	RNA	NNP
cord-254895-ym0jsir5	246	22	viruses	virus	NNS
cord-254895-ym0jsir5	246	23	and	and	CC
cord-254895-ym0jsir5	246	24	,	,	,
cord-254895-ym0jsir5	246	25	with	with	IN
cord-254895-ym0jsir5	246	26	the	the	DT
cord-254895-ym0jsir5	246	27	exception	exception	NN
cord-254895-ym0jsir5	246	28	of	of	IN
cord-254895-ym0jsir5	246	29	LGP2	LGP2	NNP
cord-254895-ym0jsir5	246	30	which	which	WDT
cord-254895-ym0jsir5	246	31	does	do	VBZ
cord-254895-ym0jsir5	246	32	not	not	RB
cord-254895-ym0jsir5	246	33	signal	signal	VB
cord-254895-ym0jsir5	246	34	itself	-PRON-	PRP
cord-254895-ym0jsir5	246	35	,	,	,
cord-254895-ym0jsir5	246	36	trigger	trigger	VB
cord-254895-ym0jsir5	246	37	a	a	DT
cord-254895-ym0jsir5	246	38	signaling	signal	VBG
cord-254895-ym0jsir5	246	39	cascade	cascade	NN
cord-254895-ym0jsir5	246	40	leading	lead	VBG
cord-254895-ym0jsir5	246	41	to	to	IN
cord-254895-ym0jsir5	246	42	the	the	DT
cord-254895-ym0jsir5	246	43	production	production	NN
cord-254895-ym0jsir5	246	44	of	of	IN
cord-254895-ym0jsir5	246	45	type	type	NN
cord-254895-ym0jsir5	246	46	I	-PRON-	PRP
cord-254895-ym0jsir5	246	47	IFNs	ifns	VBP
cord-254895-ym0jsir5	246	48	and	and	CC
cord-254895-ym0jsir5	246	49	of	of	IN
cord-254895-ym0jsir5	246	50	proinflammatory	proinflammatory	JJ
cord-254895-ym0jsir5	246	51	cytokines	cytokine	NNS
cord-254895-ym0jsir5	246	52	in	in	IN
cord-254895-ym0jsir5	246	53	response	response	NN
cord-254895-ym0jsir5	246	54	to	to	IN
cord-254895-ym0jsir5	246	55	viral	viral	JJ
cord-254895-ym0jsir5	246	56	infection	infection	NN
cord-254895-ym0jsir5	246	57	.	.	.
cord-254895-ym0jsir5	247	1	Retinoic	retinoic	JJ
cord-254895-ym0jsir5	247	2	-	-	HYPH
cord-254895-ym0jsir5	247	3	acid	acid	NN
cord-254895-ym0jsir5	247	4	-	-	HYPH
cord-254895-ym0jsir5	247	5	inducible	inducible	JJ
cord-254895-ym0jsir5	247	6	protein	protein	NN
cord-254895-ym0jsir5	248	1	I	-PRON-	PRP
cord-254895-ym0jsir5	249	1	(	(	-LRB-
cord-254895-ym0jsir5	249	2	RIG	rig	NN
cord-254895-ym0jsir5	249	3	-	-	HYPH
cord-254895-ym0jsir5	249	4	I	I	NNP
cord-254895-ym0jsir5	249	5	)	)	-RRB-
cord-254895-ym0jsir5	249	6	is	be	VBZ
cord-254895-ym0jsir5	249	7	a	a	DT
cord-254895-ym0jsir5	249	8	DExD/	DExD/	NNP
cord-254895-ym0jsir5	249	9	H	H	NNP
cord-254895-ym0jsir5	249	10	box	box	NN
cord-254895-ym0jsir5	249	11	-	-	HYPH
cord-254895-ym0jsir5	249	12	containing	contain	VBG
cord-254895-ym0jsir5	249	13	RNA	RNA	NNP
cord-254895-ym0jsir5	249	14	helicase	helicase	NNP
cord-254895-ym0jsir5	249	15	that	that	WDT
cord-254895-ym0jsir5	249	16	was	be	VBD
cord-254895-ym0jsir5	249	17	originally	originally	RB
cord-254895-ym0jsir5	249	18	identified	identify	VBN
cord-254895-ym0jsir5	249	19	as	as	IN
cord-254895-ym0jsir5	249	20	an	an	DT
cord-254895-ym0jsir5	249	21	enhancer	enhancer	NN
cord-254895-ym0jsir5	249	22	of	of	IN
cord-254895-ym0jsir5	249	23	type	type	NN
cord-254895-ym0jsir5	249	24	I	-PRON-	PRP
cord-254895-ym0jsir5	249	25	IFN	IFN	NNP
cord-254895-ym0jsir5	249	26	expression	expression	NN
cord-254895-ym0jsir5	249	27	in	in	IN
cord-254895-ym0jsir5	249	28	response	response	NN
cord-254895-ym0jsir5	249	29	to	to	IN
cord-254895-ym0jsir5	249	30	dsRNA	dsRNA	NNP
cord-254895-ym0jsir5	249	31	poly	poly	JJ
cord-254895-ym0jsir5	249	32	(	(	-LRB-
cord-254895-ym0jsir5	249	33	I	i	NN
cord-254895-ym0jsir5	249	34	:	:	:
cord-254895-ym0jsir5	249	35	C	C	NNP
cord-254895-ym0jsir5	249	36	)	)	-RRB-
cord-254895-ym0jsir5	249	37	(	(	-LRB-
cord-254895-ym0jsir5	249	38	Yoneyama	Yoneyama	NNP
cord-254895-ym0jsir5	249	39	et	et	NNP
cord-254895-ym0jsir5	249	40	al	al	NNP
cord-254895-ym0jsir5	249	41	.	.	NNP
cord-254895-ym0jsir5	249	42	,	,	,
cord-254895-ym0jsir5	249	43	2004	2004	CD
cord-254895-ym0jsir5	249	44	)	)	-RRB-
cord-254895-ym0jsir5	249	45	.	.	.
cord-254895-ym0jsir5	250	1	DExD	DExD	NNP
cord-254895-ym0jsir5	250	2	/	/	SYM
cord-254895-ym0jsir5	250	3	H	h	NN
cord-254895-ym0jsir5	250	4	box	box	NN
cord-254895-ym0jsir5	250	5	RNA	RNA	NNP
cord-254895-ym0jsir5	250	6	helicases	helicase	NNS
cord-254895-ym0jsir5	250	7	are	be	VBP
cord-254895-ym0jsir5	250	8	defined	define	VBN
cord-254895-ym0jsir5	250	9	by	by	IN
cord-254895-ym0jsir5	250	10	their	-PRON-	PRP$
cord-254895-ym0jsir5	250	11	ability	ability	NN
cord-254895-ym0jsir5	250	12	to	to	TO
cord-254895-ym0jsir5	250	13	unwind	unwind	VB
cord-254895-ym0jsir5	250	14	dsRNA	dsrna	NN
cord-254895-ym0jsir5	250	15	using	use	VBG
cord-254895-ym0jsir5	250	16	their	-PRON-	PRP$
cord-254895-ym0jsir5	250	17	intrinsic	intrinsic	JJ
cord-254895-ym0jsir5	250	18	ATPase	ATPase	NNP
cord-254895-ym0jsir5	250	19	activity	activity	NN
cord-254895-ym0jsir5	250	20	.	.	.
cord-254895-ym0jsir5	251	1	In	in	IN
cord-254895-ym0jsir5	251	2	addition	addition	NN
cord-254895-ym0jsir5	251	3	to	to	IN
cord-254895-ym0jsir5	251	4	the	the	DT
cord-254895-ym0jsir5	251	5	C	C	NNP
cord-254895-ym0jsir5	251	6	-	-	HYPH
cord-254895-ym0jsir5	251	7	terminal	terminal	NN
cord-254895-ym0jsir5	251	8	helicase	helicase	NN
cord-254895-ym0jsir5	251	9	domain	domain	NN
cord-254895-ym0jsir5	251	10	RIG	rig	NN
cord-254895-ym0jsir5	251	11	-	-	:
cord-254895-ym0jsir5	251	12	I	-PRON-	PRP
cord-254895-ym0jsir5	251	13	contains	contain	VBZ
cord-254895-ym0jsir5	251	14	two	two	CD
cord-254895-ym0jsir5	251	15	caspase	caspase	NN
cord-254895-ym0jsir5	251	16	recruitment	recruitment	NN
cord-254895-ym0jsir5	251	17	domains	domain	NNS
cord-254895-ym0jsir5	251	18	(	(	-LRB-
cord-254895-ym0jsir5	251	19	CARD	card	NN
cord-254895-ym0jsir5	251	20	)	)	-RRB-
cord-254895-ym0jsir5	251	21	at	at	IN
cord-254895-ym0jsir5	251	22	its	-PRON-	PRP$
cord-254895-ym0jsir5	251	23	N	n	CD
cord-254895-ym0jsir5	251	24	terminus	terminus	NN
cord-254895-ym0jsir5	251	25	(	(	-LRB-
cord-254895-ym0jsir5	251	26	Zhang	Zhang	NNP
cord-254895-ym0jsir5	251	27	et	et	NNP
cord-254895-ym0jsir5	251	28	al	al	NNP
cord-254895-ym0jsir5	251	29	.	.	NNP
cord-254895-ym0jsir5	251	30	,	,	,
cord-254895-ym0jsir5	251	31	2000	2000	CD
cord-254895-ym0jsir5	251	32	)	)	-RRB-
cord-254895-ym0jsir5	251	33	.	.	.
cord-254895-ym0jsir5	252	1	CARDs	card	NNS
cord-254895-ym0jsir5	252	2	are	be	VBP
cord-254895-ym0jsir5	252	3	found	find	VBN
cord-254895-ym0jsir5	252	4	in	in	IN
cord-254895-ym0jsir5	252	5	a	a	DT
cord-254895-ym0jsir5	252	6	number	number	NN
cord-254895-ym0jsir5	252	7	of	of	IN
cord-254895-ym0jsir5	252	8	caspases	caspase	NNS
cord-254895-ym0jsir5	252	9	,	,	,
cord-254895-ym0jsir5	252	10	but	but	CC
cord-254895-ym0jsir5	252	11	also	also	RB
cord-254895-ym0jsir5	252	12	in	in	IN
cord-254895-ym0jsir5	252	13	other	other	JJ
cord-254895-ym0jsir5	252	14	proteins	protein	NNS
cord-254895-ym0jsir5	252	15	such	such	JJ
cord-254895-ym0jsir5	252	16	as	as	IN
cord-254895-ym0jsir5	252	17	NOD1	NOD1	NNP
cord-254895-ym0jsir5	252	18	and	and	CC
cord-254895-ym0jsir5	252	19	NOD2	NOD2	NNPS
cord-254895-ym0jsir5	252	20	,	,	,
cord-254895-ym0jsir5	252	21	involved	involve	VBN
cord-254895-ym0jsir5	252	22	in	in	IN
cord-254895-ym0jsir5	252	23	sensing	sense	VBG
cord-254895-ym0jsir5	252	24	intracellular	intracellular	JJ
cord-254895-ym0jsir5	252	25	bacterial	bacterial	JJ
cord-254895-ym0jsir5	252	26	products	product	NNS
cord-254895-ym0jsir5	252	27	(	(	-LRB-
cord-254895-ym0jsir5	252	28	Inohara	Inohara	NNP
cord-254895-ym0jsir5	252	29	and	and	CC
cord-254895-ym0jsir5	252	30	Nunez	Nunez	NNP
cord-254895-ym0jsir5	252	31	,	,	,
cord-254895-ym0jsir5	252	32	2003	2003	CD
cord-254895-ym0jsir5	252	33	)	)	-RRB-
cord-254895-ym0jsir5	252	34	.	.	.
cord-254895-ym0jsir5	253	1	The	the	DT
cord-254895-ym0jsir5	253	2	functions	function	NNS
cord-254895-ym0jsir5	253	3	of	of	IN
cord-254895-ym0jsir5	253	4	RIG	rig	NN
cord-254895-ym0jsir5	253	5	-	-	:
cord-254895-ym0jsir5	253	6	I	-PRON-	PRP
cord-254895-ym0jsir5	253	7	have	have	VBP
cord-254895-ym0jsir5	253	8	been	be	VBN
cord-254895-ym0jsir5	253	9	analyzed	analyze	VBN
cord-254895-ym0jsir5	253	10	in	in	IN
cord-254895-ym0jsir5	253	11	detail	detail	NN
cord-254895-ym0jsir5	253	12	in	in	IN
cord-254895-ym0jsir5	253	13	the	the	DT
cord-254895-ym0jsir5	253	14	first	first	JJ
cord-254895-ym0jsir5	253	15	publication	publication	NN
cord-254895-ym0jsir5	253	16	by	by	IN
cord-254895-ym0jsir5	253	17	Yoneyama	Yoneyama	NNP
cord-254895-ym0jsir5	253	18	et	et	NNP
cord-254895-ym0jsir5	253	19	al	al	NNP
cord-254895-ym0jsir5	253	20	.	.	.
cord-254895-ym0jsir5	254	1	(	(	-LRB-
cord-254895-ym0jsir5	254	2	2004	2004	CD
cord-254895-ym0jsir5	254	3	)	)	-RRB-
cord-254895-ym0jsir5	254	4	using	use	VBG
cord-254895-ym0jsir5	254	5	deletion	deletion	NN
cord-254895-ym0jsir5	254	6	constructs	construct	NNS
cord-254895-ym0jsir5	254	7	of	of	IN
cord-254895-ym0jsir5	254	8	full	full	JJ
cord-254895-ym0jsir5	254	9	length	length	NN
cord-254895-ym0jsir5	254	10	RIG	rig	NN
cord-254895-ym0jsir5	254	11	-	-	HYPH
cord-254895-ym0jsir5	254	12	I.	I.	NNP
cord-254895-ym0jsir5	254	13	Overexpression	Overexpression	NNP
cord-254895-ym0jsir5	254	14	of	of	IN
cord-254895-ym0jsir5	254	15	the	the	DT
cord-254895-ym0jsir5	254	16	N	n	CD
cord-254895-ym0jsir5	254	17	-	-	HYPH
cord-254895-ym0jsir5	254	18	terminal	terminal	JJ
cord-254895-ym0jsir5	254	19	region	region	NN
cord-254895-ym0jsir5	254	20	of	of	IN
cord-254895-ym0jsir5	254	21	RIG	rig	NN
cord-254895-ym0jsir5	254	22	-	-	:
cord-254895-ym0jsir5	254	23	I	i	NN
cord-254895-ym0jsir5	254	24	(	(	-LRB-
cord-254895-ym0jsir5	254	25	delta	delta	NNP
cord-254895-ym0jsir5	254	26	RIG	rig	NN
cord-254895-ym0jsir5	254	27	-	-	:
cord-254895-ym0jsir5	254	28	I	I	NNP
cord-254895-ym0jsir5	254	29	)	)	-RRB-
cord-254895-ym0jsir5	254	30	comprising	comprise	VBG
cord-254895-ym0jsir5	254	31	the	the	DT
cord-254895-ym0jsir5	254	32	two	two	CD
cord-254895-ym0jsir5	254	33	tandem	tandem	NN
cord-254895-ym0jsir5	254	34	CARDs	card	NNS
cord-254895-ym0jsir5	254	35	is	be	VBZ
cord-254895-ym0jsir5	254	36	sufficient	sufficient	JJ
cord-254895-ym0jsir5	254	37	to	to	TO
cord-254895-ym0jsir5	254	38	induce	induce	VB
cord-254895-ym0jsir5	254	39	IRF3	IRF3	NNP
cord-254895-ym0jsir5	254	40	and	and	CC
cord-254895-ym0jsir5	254	41	NFkB	NFkB	NNP
cord-254895-ym0jsir5	254	42	activation	activation	NN
cord-254895-ym0jsir5	254	43	even	even	RB
cord-254895-ym0jsir5	254	44	in	in	IN
cord-254895-ym0jsir5	254	45	the	the	DT
cord-254895-ym0jsir5	254	46	absence	absence	NN
cord-254895-ym0jsir5	254	47	of	of	IN
cord-254895-ym0jsir5	254	48	a	a	DT
cord-254895-ym0jsir5	254	49	dsRNA	dsrna	NN
cord-254895-ym0jsir5	254	50	stimulus	stimulus	NN
cord-254895-ym0jsir5	254	51	or	or	CC
cord-254895-ym0jsir5	254	52	viral	viral	JJ
cord-254895-ym0jsir5	254	53	challenge	challenge	NN
cord-254895-ym0jsir5	254	54	.	.	.
cord-254895-ym0jsir5	255	1	The	the	DT
cord-254895-ym0jsir5	255	2	mutant	mutant	NN
cord-254895-ym0jsir5	255	3	of	of	IN
cord-254895-ym0jsir5	255	4	RIG	rig	NN
cord-254895-ym0jsir5	255	5	-	-	:
cord-254895-ym0jsir5	255	6	I	-PRON-	PRP
cord-254895-ym0jsir5	255	7	lacking	lack	VBG
cord-254895-ym0jsir5	255	8	the	the	DT
cord-254895-ym0jsir5	255	9	CARD	card	NN
cord-254895-ym0jsir5	255	10	domain	domain	NN
cord-254895-ym0jsir5	255	11	is	be	VBZ
cord-254895-ym0jsir5	255	12	not	not	RB
cord-254895-ym0jsir5	255	13	capable	capable	JJ
cord-254895-ym0jsir5	255	14	of	of	IN
cord-254895-ym0jsir5	255	15	transmitting	transmit	VBG
cord-254895-ym0jsir5	255	16	signals	signal	NNS
cord-254895-ym0jsir5	255	17	.	.	.
cord-254895-ym0jsir5	256	1	This	this	DT
cord-254895-ym0jsir5	256	2	N	n	NN
cord-254895-ym0jsir5	256	3	-	-	HYPH
cord-254895-ym0jsir5	256	4	terminally	terminally	RB
cord-254895-ym0jsir5	256	5	truncated	truncate	VBN
cord-254895-ym0jsir5	256	6	molecule	molecule	NN
cord-254895-ym0jsir5	256	7	even	even	RB
cord-254895-ym0jsir5	256	8	has	have	VBZ
cord-254895-ym0jsir5	256	9	a	a	DT
cord-254895-ym0jsir5	256	10	dominant	dominant	JJ
cord-254895-ym0jsir5	256	11	negative	negative	JJ
cord-254895-ym0jsir5	256	12	effect	effect	NN
cord-254895-ym0jsir5	256	13	since	since	IN
cord-254895-ym0jsir5	256	14	expression	expression	NN
cord-254895-ym0jsir5	256	15	of	of	IN
cord-254895-ym0jsir5	256	16	this	this	DT
cord-254895-ym0jsir5	256	17	domain	domain	NN
cord-254895-ym0jsir5	256	18	alone	alone	RB
cord-254895-ym0jsir5	256	19	prevents	prevent	VBZ
cord-254895-ym0jsir5	256	20	activation	activation	NN
cord-254895-ym0jsir5	256	21	of	of	IN
cord-254895-ym0jsir5	256	22	IRF3	IRF3	NNP
cord-254895-ym0jsir5	256	23	by	by	IN
cord-254895-ym0jsir5	256	24	dsRNA	dsrna	NN
cord-254895-ym0jsir5	256	25	transfection	transfection	NN
cord-254895-ym0jsir5	256	26	or	or	CC
cord-254895-ym0jsir5	256	27	NDV	ndv	JJ
cord-254895-ym0jsir5	256	28	infection	infection	NN
cord-254895-ym0jsir5	257	1	(	(	-LRB-
cord-254895-ym0jsir5	257	2	Yoneyama	Yoneyama	NNP
cord-254895-ym0jsir5	257	3	et	et	NNP
cord-254895-ym0jsir5	257	4	al	al	NNP
cord-254895-ym0jsir5	257	5	.	.	NNP
cord-254895-ym0jsir5	257	6	,	,	,
cord-254895-ym0jsir5	257	7	2004	2004	CD
cord-254895-ym0jsir5	257	8	)	)	-RRB-
cord-254895-ym0jsir5	257	9	.	.	.
cord-254895-ym0jsir5	258	1	Since	since	IN
cord-254895-ym0jsir5	258	2	CARDs	card	NNS
cord-254895-ym0jsir5	258	3	are	be	VBP
cord-254895-ym0jsir5	258	4	known	know	VBN
cord-254895-ym0jsir5	258	5	to	to	TO
cord-254895-ym0jsir5	258	6	engage	engage	VB
cord-254895-ym0jsir5	258	7	in	in	IN
cord-254895-ym0jsir5	258	8	homophilic	homophilic	NNP
cord-254895-ym0jsir5	258	9	protein	protein	NN
cord-254895-ym0jsir5	258	10	-	-	HYPH
cord-254895-ym0jsir5	258	11	protein	protein	NN
cord-254895-ym0jsir5	258	12	interactions	interaction	NNS
cord-254895-ym0jsir5	258	13	in	in	IN
cord-254895-ym0jsir5	258	14	other	other	JJ
cord-254895-ym0jsir5	258	15	signal	signal	NN
cord-254895-ym0jsir5	258	16	transduction	transduction	NN
cord-254895-ym0jsir5	258	17	pathways	pathway	NNS
cord-254895-ym0jsir5	258	18	,	,	,
cord-254895-ym0jsir5	258	19	it	-PRON-	PRP
cord-254895-ym0jsir5	258	20	was	be	VBD
cord-254895-ym0jsir5	258	21	therefore	therefore	RB
cord-254895-ym0jsir5	258	22	likely	likely	JJ
cord-254895-ym0jsir5	258	23	that	that	IN
cord-254895-ym0jsir5	258	24	the	the	DT
cord-254895-ym0jsir5	258	25	CARDs	card	NNS
cord-254895-ym0jsir5	258	26	of	of	IN
cord-254895-ym0jsir5	258	27	RIG	rig	NN
cord-254895-ym0jsir5	258	28	-	-	:
cord-254895-ym0jsir5	258	29	I	-PRON-	PRP
cord-254895-ym0jsir5	258	30	interact	interact	VBP
cord-254895-ym0jsir5	258	31	with	with	IN
cord-254895-ym0jsir5	258	32	other	other	JJ
cord-254895-ym0jsir5	258	33	CARD	card	NN
cord-254895-ym0jsir5	258	34	containing	contain	VBG
cord-254895-ym0jsir5	258	35	molecules	molecule	NNS
cord-254895-ym0jsir5	258	36	to	to	TO
cord-254895-ym0jsir5	258	37	activate	activate	VB
cord-254895-ym0jsir5	258	38	downstream	downstream	JJ
cord-254895-ym0jsir5	258	39	signaling	signal	VBG
cord-254895-ym0jsir5	258	40	molecules	molecule	NNS
cord-254895-ym0jsir5	258	41	.	.	.
cord-254895-ym0jsir5	259	1	The	the	DT
cord-254895-ym0jsir5	259	2	adaptor	adaptor	NN
cord-254895-ym0jsir5	259	3	protein	protein	NN
cord-254895-ym0jsir5	259	4	that	that	WDT
cord-254895-ym0jsir5	259	5	links	link	VBZ
cord-254895-ym0jsir5	259	6	RIG	rig	NN
cord-254895-ym0jsir5	259	7	-	-	:
cord-254895-ym0jsir5	259	8	I	i	NN
cord-254895-ym0jsir5	259	9	to	to	IN
cord-254895-ym0jsir5	259	10	the	the	DT
cord-254895-ym0jsir5	259	11	activation	activation	NN
cord-254895-ym0jsir5	259	12	of	of	IN
cord-254895-ym0jsir5	259	13	TBK1	TBK1	NNP
cord-254895-ym0jsir5	259	14	/	/	SYM
cord-254895-ym0jsir5	259	15	IKKe	IKKe	NNS
cord-254895-ym0jsir5	259	16	and	and	CC
cord-254895-ym0jsir5	259	17	IKKb	IKKb	NNP
cord-254895-ym0jsir5	259	18	was	be	VBD
cord-254895-ym0jsir5	259	19	identified	identify	VBN
cord-254895-ym0jsir5	259	20	and	and	CC
cord-254895-ym0jsir5	259	21	functionally	functionally	RB
cord-254895-ym0jsir5	259	22	characterized	characterize	VBN
cord-254895-ym0jsir5	259	23	by	by	IN
cord-254895-ym0jsir5	259	24	four	four	CD
cord-254895-ym0jsir5	259	25	independent	independent	JJ
cord-254895-ym0jsir5	259	26	groups	group	NNS
cord-254895-ym0jsir5	259	27	and	and	CC
cord-254895-ym0jsir5	259	28	designated	designate	VBN
cord-254895-ym0jsir5	259	29	as	as	IN
cord-254895-ym0jsir5	259	30	IFN	IFN	NNP
cord-254895-ym0jsir5	259	31	-	-	HYPH
cord-254895-ym0jsir5	259	32	b	b	NNP
cord-254895-ym0jsir5	259	33	promoter	promoter	NN
cord-254895-ym0jsir5	259	34	stimulator	stimulator	NN
cord-254895-ym0jsir5	259	35	1	1	CD
cord-254895-ym0jsir5	259	36	(	(	-LRB-
cord-254895-ym0jsir5	259	37	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	259	38	)	)	-RRB-
cord-254895-ym0jsir5	259	39	,	,	,
cord-254895-ym0jsir5	259	40	mitochondrial	mitochondrial	JJ
cord-254895-ym0jsir5	259	41	antiviral	antiviral	JJ
cord-254895-ym0jsir5	259	42	signaling	signal	VBG
cord-254895-ym0jsir5	259	43	protein	protein	NN
cord-254895-ym0jsir5	259	44	(	(	-LRB-
cord-254895-ym0jsir5	259	45	MAVS	MAVS	NNP
cord-254895-ym0jsir5	259	46	)	)	-RRB-
cord-254895-ym0jsir5	259	47	,	,	,
cord-254895-ym0jsir5	259	48	virus	virus	NN
cord-254895-ym0jsir5	259	49	-	-	HYPH
cord-254895-ym0jsir5	259	50	induced	induce	VBN
cord-254895-ym0jsir5	259	51	signaling	signal	VBG
cord-254895-ym0jsir5	259	52	adapter	adapter	NN
cord-254895-ym0jsir5	259	53	(	(	-LRB-
cord-254895-ym0jsir5	259	54	VISA	VISA	NNP
cord-254895-ym0jsir5	259	55	)	)	-RRB-
cord-254895-ym0jsir5	259	56	(	(	-LRB-
cord-254895-ym0jsir5	259	57	Xu	Xu	NNP
cord-254895-ym0jsir5	259	58	et	et	NNP
cord-254895-ym0jsir5	259	59	al	al	NNP
cord-254895-ym0jsir5	259	60	.	.	NNP
cord-254895-ym0jsir5	259	61	,	,	,
cord-254895-ym0jsir5	259	62	2005	2005	CD
cord-254895-ym0jsir5	259	63	)	)	-RRB-
cord-254895-ym0jsir5	259	64	and	and	CC
cord-254895-ym0jsir5	259	65	CARD	card	NN
cord-254895-ym0jsir5	259	66	adapter	adapter	NN
cord-254895-ym0jsir5	259	67	inducing	induce	VBG
cord-254895-ym0jsir5	259	68	IFN	IFN	NNP
cord-254895-ym0jsir5	259	69	-	-	HYPH
cord-254895-ym0jsir5	259	70	b	b	NNP
cord-254895-ym0jsir5	259	71	(	(	-LRB-
cord-254895-ym0jsir5	259	72	CARDIF	CARDIF	NNP
cord-254895-ym0jsir5	259	73	)	)	-RRB-
cord-254895-ym0jsir5	260	1	(	(	-LRB-
cord-254895-ym0jsir5	260	2	Meylan	Meylan	NNP
cord-254895-ym0jsir5	260	3	et	et	NNP
cord-254895-ym0jsir5	260	4	al	al	NNP
cord-254895-ym0jsir5	260	5	.	.	NNP
cord-254895-ym0jsir5	260	6	,	,	,
cord-254895-ym0jsir5	260	7	2005	2005	CD
cord-254895-ym0jsir5	260	8	)	)	-RRB-
cord-254895-ym0jsir5	260	9	,	,	,
cord-254895-ym0jsir5	260	10	respectively	respectively	RB
cord-254895-ym0jsir5	260	11	.	.	.
cord-254895-ym0jsir5	261	1	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	261	2	contains	contain	VBZ
cord-254895-ym0jsir5	261	3	an	an	DT
cord-254895-ym0jsir5	261	4	N	n	CD
cord-254895-ym0jsir5	261	5	-	-	HYPH
cord-254895-ym0jsir5	261	6	terminal	terminal	JJ
cord-254895-ym0jsir5	261	7	CARD	card	NN
cord-254895-ym0jsir5	261	8	domain	domain	NN
cord-254895-ym0jsir5	261	9	that	that	WDT
cord-254895-ym0jsir5	261	10	interacts	interact	VBZ
cord-254895-ym0jsir5	261	11	with	with	IN
cord-254895-ym0jsir5	261	12	the	the	DT
cord-254895-ym0jsir5	261	13	tandem	tandem	JJ
cord-254895-ym0jsir5	261	14	CARD	card	NN
cord-254895-ym0jsir5	261	15	domains	domain	NNS
cord-254895-ym0jsir5	261	16	of	of	IN
cord-254895-ym0jsir5	261	17	RIG	rig	NN
cord-254895-ym0jsir5	261	18	-	-	:
cord-254895-ym0jsir5	261	19	I	I	NNP
cord-254895-ym0jsir5	261	20	and	and	CC
cord-254895-ym0jsir5	261	21	a	a	DT
cord-254895-ym0jsir5	261	22	C	c	NN
cord-254895-ym0jsir5	261	23	-	-	HYPH
cord-254895-ym0jsir5	261	24	terminal	terminal	NN
cord-254895-ym0jsir5	261	25	hydrophobic	hydrophobic	JJ
cord-254895-ym0jsir5	261	26	transmembrane	transmembrane	NN
cord-254895-ym0jsir5	261	27	(	(	-LRB-
cord-254895-ym0jsir5	261	28	TM	TM	NNP
cord-254895-ym0jsir5	261	29	)	)	-RRB-
cord-254895-ym0jsir5	261	30	domain	domain	NN
cord-254895-ym0jsir5	261	31	that	that	WDT
cord-254895-ym0jsir5	261	32	localizes	localize	VBZ
cord-254895-ym0jsir5	261	33	it	-PRON-	PRP
cord-254895-ym0jsir5	261	34	to	to	IN
cord-254895-ym0jsir5	261	35	the	the	DT
cord-254895-ym0jsir5	261	36	outer	outer	JJ
cord-254895-ym0jsir5	261	37	mitochondrial	mitochondrial	NN
cord-254895-ym0jsir5	261	38	membrane	membrane	NN
cord-254895-ym0jsir5	261	39	.	.	.
cord-254895-ym0jsir5	262	1	Deletion	deletion	NN
cord-254895-ym0jsir5	262	2	analyses	analysis	NNS
cord-254895-ym0jsir5	262	3	have	have	VBP
cord-254895-ym0jsir5	262	4	shown	show	VBN
cord-254895-ym0jsir5	262	5	that	that	IN
cord-254895-ym0jsir5	262	6	both	both	CC
cord-254895-ym0jsir5	262	7	the	the	DT
cord-254895-ym0jsir5	262	8	CARD	card	NN
cord-254895-ym0jsir5	262	9	and	and	CC
cord-254895-ym0jsir5	262	10	the	the	DT
cord-254895-ym0jsir5	262	11	transmembrane	transmembrane	NN
cord-254895-ym0jsir5	262	12	domain	domain	NN
cord-254895-ym0jsir5	262	13	are	be	VBP
cord-254895-ym0jsir5	262	14	essential	essential	JJ
cord-254895-ym0jsir5	262	15	for	for	IN
cord-254895-ym0jsir5	262	16	the	the	DT
cord-254895-ym0jsir5	262	17	function	function	NN
cord-254895-ym0jsir5	262	18	of	of	IN
cord-254895-ym0jsir5	262	19	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	262	20	.	.	.
cord-254895-ym0jsir5	263	1	The	the	DT
cord-254895-ym0jsir5	263	2	mitochondrial	mitochondrial	JJ
cord-254895-ym0jsir5	263	3	localization	localization	NN
cord-254895-ym0jsir5	263	4	of	of	IN
cord-254895-ym0jsir5	263	5	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	263	6	is	be	VBZ
cord-254895-ym0jsir5	263	7	essential	essential	JJ
cord-254895-ym0jsir5	263	8	for	for	IN
cord-254895-ym0jsir5	263	9	its	-PRON-	PRP$
cord-254895-ym0jsir5	263	10	activity	activity	NN
cord-254895-ym0jsir5	263	11	because	because	IN
cord-254895-ym0jsir5	263	12	deletion	deletion	NN
cord-254895-ym0jsir5	263	13	of	of	IN
cord-254895-ym0jsir5	263	14	the	the	DT
cord-254895-ym0jsir5	263	15	TM	TM	NNP
cord-254895-ym0jsir5	263	16	domain	domain	NN
cord-254895-ym0jsir5	263	17	,	,	,
cord-254895-ym0jsir5	263	18	which	which	WDT
cord-254895-ym0jsir5	263	19	leads	lead	VBZ
cord-254895-ym0jsir5	263	20	to	to	IN
cord-254895-ym0jsir5	263	21	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	263	22	expression	expression	NN
cord-254895-ym0jsir5	263	23	of	of	IN
cord-254895-ym0jsir5	263	24	the	the	DT
cord-254895-ym0jsir5	263	25	protein	protein	NN
cord-254895-ym0jsir5	263	26	,	,	,
cord-254895-ym0jsir5	263	27	abolishes	abolish	VBZ
cord-254895-ym0jsir5	263	28	the	the	DT
cord-254895-ym0jsir5	263	29	signaling	signal	VBG
cord-254895-ym0jsir5	263	30	function	function	NN
cord-254895-ym0jsir5	263	31	of	of	IN
cord-254895-ym0jsir5	263	32	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	263	33	.	.	.
cord-254895-ym0jsir5	264	1	The	the	DT
cord-254895-ym0jsir5	264	2	binding	binding	NN
cord-254895-ym0jsir5	264	3	of	of	IN
cord-254895-ym0jsir5	264	4	dsRNA	dsrna	NN
cord-254895-ym0jsir5	264	5	to	to	IN
cord-254895-ym0jsir5	264	6	the	the	DT
cord-254895-ym0jsir5	264	7	helicase	helicase	NN
cord-254895-ym0jsir5	264	8	domain	domain	NN
cord-254895-ym0jsir5	264	9	of	of	IN
cord-254895-ym0jsir5	264	10	RIG	rig	NN
cord-254895-ym0jsir5	264	11	-	-	:
cord-254895-ym0jsir5	264	12	I	-PRON-	PRP
cord-254895-ym0jsir5	264	13	likely	likely	RB
cord-254895-ym0jsir5	264	14	induces	induce	VBZ
cord-254895-ym0jsir5	264	15	a	a	DT
cord-254895-ym0jsir5	264	16	conformational	conformational	JJ
cord-254895-ym0jsir5	264	17	change	change	NN
cord-254895-ym0jsir5	264	18	that	that	WDT
cord-254895-ym0jsir5	264	19	exposes	expose	VBZ
cord-254895-ym0jsir5	264	20	the	the	DT
cord-254895-ym0jsir5	264	21	N	n	CD
cord-254895-ym0jsir5	264	22	-	-	HYPH
cord-254895-ym0jsir5	264	23	terminal	terminal	NN
cord-254895-ym0jsir5	264	24	CARD	card	NN
cord-254895-ym0jsir5	264	25	domains	domain	NNS
cord-254895-ym0jsir5	264	26	to	to	TO
cord-254895-ym0jsir5	264	27	recruit	recruit	VB
cord-254895-ym0jsir5	264	28	its	-PRON-	PRP$
cord-254895-ym0jsir5	264	29	signaling	signaling	NN
cord-254895-ym0jsir5	264	30	adaptor	adaptor	NN
cord-254895-ym0jsir5	264	31	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	264	32	.	.	.
cord-254895-ym0jsir5	265	1	This	this	DT
cord-254895-ym0jsir5	265	2	interaction	interaction	NN
cord-254895-ym0jsir5	265	3	subsequently	subsequently	RB
cord-254895-ym0jsir5	265	4	induces	induce	VBZ
cord-254895-ym0jsir5	265	5	IFN	IFN	NNP
cord-254895-ym0jsir5	265	6	-	-	HYPH
cord-254895-ym0jsir5	265	7	a	a	DT
cord-254895-ym0jsir5	265	8	/	/	SYM
cord-254895-ym0jsir5	265	9	INF	inf	NN
cord-254895-ym0jsir5	265	10	-	-	HYPH
cord-254895-ym0jsir5	265	11	b	b	NNP
cord-254895-ym0jsir5	265	12	and	and	CC
cord-254895-ym0jsir5	265	13	IFN	IFN	NNP
cord-254895-ym0jsir5	265	14	-	-	HYPH
cord-254895-ym0jsir5	265	15	induced	induce	VBN
cord-254895-ym0jsir5	265	16	antiviral	antiviral	JJ
cord-254895-ym0jsir5	265	17	effector	effector	NN
cord-254895-ym0jsir5	265	18	mechanisms	mechanism	NNS
cord-254895-ym0jsir5	265	19	that	that	WDT
cord-254895-ym0jsir5	265	20	suppress	suppress	VBP
cord-254895-ym0jsir5	265	21	virus	virus	NN
cord-254895-ym0jsir5	265	22	replication	replication	NN
cord-254895-ym0jsir5	265	23	(	(	-LRB-
cord-254895-ym0jsir5	265	24	Meylan	Meylan	NNP
cord-254895-ym0jsir5	265	25	et	et	NNP
cord-254895-ym0jsir5	265	26	al	al	NNP
cord-254895-ym0jsir5	265	27	.	.	NNP
cord-254895-ym0jsir5	265	28	,	,	,
cord-254895-ym0jsir5	265	29	2006	2006	CD
cord-254895-ym0jsir5	265	30	)	)	-RRB-
cord-254895-ym0jsir5	265	31	.	.	.
cord-254895-ym0jsir5	266	1	In	in	IN
cord-254895-ym0jsir5	266	2	a	a	DT
cord-254895-ym0jsir5	266	3	recent	recent	JJ
cord-254895-ym0jsir5	266	4	publication	publication	NN
cord-254895-ym0jsir5	266	5	Saito	Saito	NNP
cord-254895-ym0jsir5	266	6	et	et	NNP
cord-254895-ym0jsir5	266	7	al	al	NNP
cord-254895-ym0jsir5	266	8	.	.	NNP
cord-254895-ym0jsir5	266	9	reported	report	VBD
cord-254895-ym0jsir5	266	10	that	that	IN
cord-254895-ym0jsir5	266	11	an	an	DT
cord-254895-ym0jsir5	266	12	internal	internal	JJ
cord-254895-ym0jsir5	266	13	repressor	repressor	NN
cord-254895-ym0jsir5	266	14	(	(	-LRB-
cord-254895-ym0jsir5	266	15	or	or	CC
cord-254895-ym0jsir5	266	16	regulatory	regulatory	JJ
cord-254895-ym0jsir5	266	17	)	)	-RRB-
cord-254895-ym0jsir5	266	18	domain	domain	NN
cord-254895-ym0jsir5	266	19	(	(	-LRB-
cord-254895-ym0jsir5	266	20	RD	RD	NNP
cord-254895-ym0jsir5	266	21	)	)	-RRB-
cord-254895-ym0jsir5	266	22	at	at	IN
cord-254895-ym0jsir5	266	23	the	the	DT
cord-254895-ym0jsir5	266	24	C	C	NNP
cord-254895-ym0jsir5	266	25	-	-	HYPH
cord-254895-ym0jsir5	266	26	terminus	terminus	NN
cord-254895-ym0jsir5	266	27	controls	control	VBZ
cord-254895-ym0jsir5	266	28	RIG	rig	NN
cord-254895-ym0jsir5	266	29	-	-	:
cord-254895-ym0jsir5	266	30	I	-PRON-	PRP
cord-254895-ym0jsir5	266	31	multimerization	multimerization	NN
cord-254895-ym0jsir5	266	32	and	and	CC
cord-254895-ym0jsir5	266	33	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	266	34	interaction	interaction	NN
cord-254895-ym0jsir5	266	35	during	during	IN
cord-254895-ym0jsir5	266	36	virus	virus	NN
cord-254895-ym0jsir5	266	37	infection	infection	NN
cord-254895-ym0jsir5	266	38	and	and	CC
cord-254895-ym0jsir5	266	39	RNA	RNA	NNP
cord-254895-ym0jsir5	266	40	binding	binding	NN
cord-254895-ym0jsir5	266	41	(	(	-LRB-
cord-254895-ym0jsir5	266	42	Saito	Saito	NNP
cord-254895-ym0jsir5	266	43	et	et	FW
cord-254895-ym0jsir5	266	44	al	al	NNP
cord-254895-ym0jsir5	266	45	.	.	NNP
cord-254895-ym0jsir5	266	46	,	,	,
cord-254895-ym0jsir5	266	47	2007	2007	CD
cord-254895-ym0jsir5	266	48	)	)	-RRB-
cord-254895-ym0jsir5	266	49	.	.	.
cord-254895-ym0jsir5	267	1	Expression	expression	NN
cord-254895-ym0jsir5	267	2	of	of	IN
cord-254895-ym0jsir5	267	3	the	the	DT
cord-254895-ym0jsir5	267	4	C	C	NNP
cord-254895-ym0jsir5	267	5	-	-	HYPH
cord-254895-ym0jsir5	267	6	terminal	terminal	NN
cord-254895-ym0jsir5	267	7	RD	RD	NNP
cord-254895-ym0jsir5	267	8	domain	domain	NN
cord-254895-ym0jsir5	267	9	,	,	,
cord-254895-ym0jsir5	267	10	encompassing	encompass	VBG
cord-254895-ym0jsir5	267	11	the	the	DT
cord-254895-ym0jsir5	267	12	amino	amino	NN
cord-254895-ym0jsir5	267	13	acids	acid	NNS
cord-254895-ym0jsir5	267	14	735	735	CD
cord-254895-ym0jsir5	267	15	-	-	HYPH
cord-254895-ym0jsir5	267	16	925	925	CD
cord-254895-ym0jsir5	267	17	of	of	IN
cord-254895-ym0jsir5	267	18	the	the	DT
cord-254895-ym0jsir5	267	19	RIG	rig	NN
cord-254895-ym0jsir5	267	20	-	-	:
cord-254895-ym0jsir5	267	21	I	-PRON-	PRP
cord-254895-ym0jsir5	267	22	protein	protein	NN
cord-254895-ym0jsir5	267	23	,	,	,
cord-254895-ym0jsir5	267	24	prevents	prevent	VBZ
cord-254895-ym0jsir5	267	25	signaling	signal	VBG
cord-254895-ym0jsir5	267	26	to	to	IN
cord-254895-ym0jsir5	267	27	the	the	DT
cord-254895-ym0jsir5	267	28	IFN	IFN	NNP
cord-254895-ym0jsir5	267	29	-	-	HYPH
cord-254895-ym0jsir5	267	30	b	b	NN
cord-254895-ym0jsir5	267	31	promoter	promoter	NN
cord-254895-ym0jsir5	267	32	and	and	CC
cord-254895-ym0jsir5	267	33	increased	increase	VBN
cord-254895-ym0jsir5	267	34	cellular	cellular	JJ
cord-254895-ym0jsir5	267	35	permissiveness	permissiveness	NN
cord-254895-ym0jsir5	267	36	to	to	IN
cord-254895-ym0jsir5	267	37	hepatitis	hepatitis	NN
cord-254895-ym0jsir5	267	38	C	C	NNP
cord-254895-ym0jsir5	267	39	virus	virus	NN
cord-254895-ym0jsir5	267	40	,	,	,
cord-254895-ym0jsir5	267	41	whereas	whereas	IN
cord-254895-ym0jsir5	267	42	deletion	deletion	NN
cord-254895-ym0jsir5	267	43	of	of	IN
cord-254895-ym0jsir5	267	44	the	the	DT
cord-254895-ym0jsir5	267	45	RIG	rig	NN
cord-254895-ym0jsir5	267	46	-	-	:
cord-254895-ym0jsir5	267	47	I	I	NNP
cord-254895-ym0jsir5	267	48	RD	RD	NNP
cord-254895-ym0jsir5	267	49	results	result	NNS
cord-254895-ym0jsir5	267	50	in	in	IN
cord-254895-ym0jsir5	267	51	constitutive	constitutive	JJ
cord-254895-ym0jsir5	267	52	signaling	signaling	NN
cord-254895-ym0jsir5	267	53	.	.	.
cord-254895-ym0jsir5	268	1	Saito	Saito	NNP
cord-254895-ym0jsir5	268	2	et	et	NNP
cord-254895-ym0jsir5	268	3	al	al	NNP
cord-254895-ym0jsir5	268	4	.	.	.
cord-254895-ym0jsir5	269	1	suggest	suggest	VB
cord-254895-ym0jsir5	269	2	a	a	DT
cord-254895-ym0jsir5	269	3	model	model	NN
cord-254895-ym0jsir5	269	4	of	of	IN
cord-254895-ym0jsir5	269	5	RIG-	RIG-	NNP
cord-254895-ym0jsir5	270	1	I	-PRON-	PRP
cord-254895-ym0jsir5	270	2	autoregulation	autoregulation	NN
cord-254895-ym0jsir5	270	3	and	and	CC
cord-254895-ym0jsir5	270	4	signaling	signal	VBG
cord-254895-ym0jsir5	270	5	predicting	predict	VBG
cord-254895-ym0jsir5	270	6	that	that	IN
cord-254895-ym0jsir5	270	7	in	in	IN
cord-254895-ym0jsir5	270	8	resting	rest	VBG
cord-254895-ym0jsir5	270	9	cells	cell	NNS
cord-254895-ym0jsir5	270	10	the	the	DT
cord-254895-ym0jsir5	270	11	C	C	NNP
cord-254895-ym0jsir5	270	12	-	-	HYPH
cord-254895-ym0jsir5	270	13	terminal	terminal	NN
cord-254895-ym0jsir5	270	14	RD	RD	NNP
cord-254895-ym0jsir5	270	15	mediates	mediate	VBZ
cord-254895-ym0jsir5	270	16	a	a	DT
cord-254895-ym0jsir5	270	17	conformation	conformation	NN
cord-254895-ym0jsir5	270	18	of	of	IN
cord-254895-ym0jsir5	270	19	RIG-	RIG-	NNP
cord-254895-ym0jsir5	271	1	I	-PRON-	PRP
cord-254895-ym0jsir5	271	2	that	that	WDT
cord-254895-ym0jsir5	271	3	masks	mask	VBZ
cord-254895-ym0jsir5	271	4	the	the	DT
cord-254895-ym0jsir5	271	5	CARDs	card	NNS
cord-254895-ym0jsir5	271	6	from	from	IN
cord-254895-ym0jsir5	271	7	signaling	signal	VBG
cord-254895-ym0jsir5	271	8	.	.	.
cord-254895-ym0jsir5	272	1	Once	once	IN
cord-254895-ym0jsir5	272	2	the	the	DT
cord-254895-ym0jsir5	272	3	cell	cell	NN
cord-254895-ym0jsir5	272	4	is	be	VBZ
cord-254895-ym0jsir5	272	5	infected	infect	VBN
cord-254895-ym0jsir5	272	6	with	with	IN
cord-254895-ym0jsir5	272	7	virus	virus	NN
cord-254895-ym0jsir5	272	8	,	,	,
cord-254895-ym0jsir5	272	9	RIG	rig	NN
cord-254895-ym0jsir5	272	10	-	-	:
cord-254895-ym0jsir5	272	11	I	-PRON-	PRP
cord-254895-ym0jsir5	272	12	activation	activation	NN
cord-254895-ym0jsir5	272	13	and	and	CC
cord-254895-ym0jsir5	272	14	signaling	signaling	NN
cord-254895-ym0jsir5	272	15	occurs	occur	VBZ
cord-254895-ym0jsir5	272	16	in	in	IN
cord-254895-ym0jsir5	272	17	a	a	DT
cord-254895-ym0jsir5	272	18	stepwise	stepwise	JJ
cord-254895-ym0jsir5	272	19	manner	manner	NN
cord-254895-ym0jsir5	272	20	involving	involve	VBG
cord-254895-ym0jsir5	272	21	dsRNA	dsrna	NN
cord-254895-ym0jsir5	272	22	binding	bind	VBG
cord-254895-ym0jsir5	272	23	and	and	CC
cord-254895-ym0jsir5	272	24	conformational	conformational	JJ
cord-254895-ym0jsir5	272	25	changes	change	NNS
cord-254895-ym0jsir5	272	26	that	that	WDT
cord-254895-ym0jsir5	272	27	subsequently	subsequently	RB
cord-254895-ym0jsir5	272	28	facilitate	facilitate	VBP
cord-254895-ym0jsir5	272	29	self	self	NN
cord-254895-ym0jsir5	272	30	-	-	HYPH
cord-254895-ym0jsir5	272	31	association	association	NN
cord-254895-ym0jsir5	272	32	and	and	CC
cord-254895-ym0jsir5	272	33	interaction	interaction	NN
cord-254895-ym0jsir5	272	34	with	with	IN
cord-254895-ym0jsir5	272	35	the	the	DT
cord-254895-ym0jsir5	272	36	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	272	37	signaling	signal	VBG
cord-254895-ym0jsir5	272	38	adaptor	adaptor	NN
cord-254895-ym0jsir5	272	39	.	.	.
cord-254895-ym0jsir5	273	1	These	these	DT
cord-254895-ym0jsir5	273	2	conformational	conformational	JJ
cord-254895-ym0jsir5	273	3	changes	change	NNS
cord-254895-ym0jsir5	273	4	comprising	comprise	VBG
cord-254895-ym0jsir5	273	5	displacement	displacement	NN
cord-254895-ym0jsir5	273	6	of	of	IN
cord-254895-ym0jsir5	273	7	the	the	DT
cord-254895-ym0jsir5	273	8	RD	RD	NNP
cord-254895-ym0jsir5	273	9	and	and	CC
cord-254895-ym0jsir5	273	10	unmasking	unmasking	NN
cord-254895-ym0jsir5	273	11	of	of	IN
cord-254895-ym0jsir5	273	12	the	the	DT
cord-254895-ym0jsir5	273	13	CARDs	card	NNS
cord-254895-ym0jsir5	273	14	for	for	IN
cord-254895-ym0jsir5	273	15	signaling	signal	VBG
cord-254895-ym0jsir5	273	16	via	via	IN
cord-254895-ym0jsir5	273	17	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	273	18	might	may	MD
cord-254895-ym0jsir5	273	19	be	be	VB
cord-254895-ym0jsir5	273	20	triggered	trigger	VBN
cord-254895-ym0jsir5	273	21	by	by	IN
cord-254895-ym0jsir5	273	22	ATP	ATP	NNP
cord-254895-ym0jsir5	273	23	hydrolysis	hydrolysis	NN
cord-254895-ym0jsir5	273	24	.	.	.
cord-254895-ym0jsir5	274	1	Saito	Saito	NNP
cord-254895-ym0jsir5	274	2	et	et	NNP
cord-254895-ym0jsir5	274	3	al	al	NNP
cord-254895-ym0jsir5	274	4	.	.	.
cord-254895-ym0jsir5	275	1	also	also	RB
cord-254895-ym0jsir5	275	2	identified	identify	VBD
cord-254895-ym0jsir5	275	3	an	an	DT
cord-254895-ym0jsir5	275	4	analogous	analogous	JJ
cord-254895-ym0jsir5	275	5	RD	RD	NNP
cord-254895-ym0jsir5	275	6	within	within	IN
cord-254895-ym0jsir5	275	7	the	the	DT
cord-254895-ym0jsir5	275	8	C	C	NNP
cord-254895-ym0jsir5	275	9	terminus	terminus	NN
cord-254895-ym0jsir5	275	10	of	of	IN
cord-254895-ym0jsir5	275	11	LGP2	LGP2	NNP
cord-254895-ym0jsir5	275	12	suggesting	suggest	VBG
cord-254895-ym0jsir5	275	13	that	that	IN
cord-254895-ym0jsir5	275	14	LGP2	LGP2	NNP
cord-254895-ym0jsir5	275	15	might	may	MD
cord-254895-ym0jsir5	275	16	inhibit	inhibit	VB
cord-254895-ym0jsir5	275	17	RIG	rig	NN
cord-254895-ym0jsir5	275	18	-	-	:
cord-254895-ym0jsir5	275	19	I	-PRON-	PRP
cord-254895-ym0jsir5	275	20	through	through	IN
cord-254895-ym0jsir5	275	21	their	-PRON-	PRP$
cord-254895-ym0jsir5	275	22	RD	RD	NNP
cord-254895-ym0jsir5	275	23	interactions	interaction	NNS
cord-254895-ym0jsir5	275	24	.	.	.
cord-254895-ym0jsir5	276	1	LGP2	LGP2	NNP
cord-254895-ym0jsir5	276	2	is	be	VBZ
cord-254895-ym0jsir5	276	3	a	a	DT
cord-254895-ym0jsir5	276	4	close	close	JJ
cord-254895-ym0jsir5	276	5	relative	relative	NN
cord-254895-ym0jsir5	276	6	of	of	IN
cord-254895-ym0jsir5	276	7	RIG	rig	NN
cord-254895-ym0jsir5	276	8	-	-	:
cord-254895-ym0jsir5	276	9	I	I	NNP
cord-254895-ym0jsir5	276	10	,	,	,
cord-254895-ym0jsir5	276	11	which	which	WDT
cord-254895-ym0jsir5	276	12	lacks	lack	VBZ
cord-254895-ym0jsir5	276	13	the	the	DT
cord-254895-ym0jsir5	276	14	CARDs	card	NNS
cord-254895-ym0jsir5	276	15	,	,	,
cord-254895-ym0jsir5	276	16	but	but	CC
cord-254895-ym0jsir5	276	17	is	be	VBZ
cord-254895-ym0jsir5	276	18	capable	capable	JJ
cord-254895-ym0jsir5	276	19	of	of	IN
cord-254895-ym0jsir5	276	20	binding	bind	VBG
cord-254895-ym0jsir5	276	21	dsRNA	dsrna	NN
cord-254895-ym0jsir5	276	22	.	.	.
cord-254895-ym0jsir5	277	1	Thus	thus	RB
cord-254895-ym0jsir5	277	2	,	,	,
cord-254895-ym0jsir5	277	3	LGP2	LGP2	NNP
cord-254895-ym0jsir5	277	4	may	may	MD
cord-254895-ym0jsir5	277	5	act	act	VB
cord-254895-ym0jsir5	277	6	as	as	IN
cord-254895-ym0jsir5	277	7	a	a	DT
cord-254895-ym0jsir5	277	8	postinduction	postinduction	NN
cord-254895-ym0jsir5	277	9	repressor	repressor	NN
cord-254895-ym0jsir5	277	10	of	of	IN
cord-254895-ym0jsir5	277	11	RIG	rig	NN
cord-254895-ym0jsir5	277	12	-	-	:
cord-254895-ym0jsir5	277	13	I	-PRON-	PRP
cord-254895-ym0jsir5	277	14	signaling	signal	VBG
cord-254895-ym0jsir5	277	15	.	.	.
cord-254895-ym0jsir5	278	1	From	from	IN
cord-254895-ym0jsir5	278	2	several	several	JJ
cord-254895-ym0jsir5	278	3	studies	study	NNS
cord-254895-ym0jsir5	278	4	it	-PRON-	PRP
cord-254895-ym0jsir5	278	5	is	be	VBZ
cord-254895-ym0jsir5	278	6	known	know	VBN
cord-254895-ym0jsir5	278	7	that	that	DT
cord-254895-ym0jsir5	278	8	RIG	rig	NN
cord-254895-ym0jsir5	279	1	-I	-I	NNP
cord-254895-ym0jsir5	279	2	is	be	VBZ
cord-254895-ym0jsir5	279	3	essential	essential	JJ
cord-254895-ym0jsir5	279	4	for	for	IN
cord-254895-ym0jsir5	279	5	antiviral	antiviral	JJ
cord-254895-ym0jsir5	279	6	responses	response	NNS
cord-254895-ym0jsir5	279	7	to	to	IN
cord-254895-ym0jsir5	279	8	a	a	DT
cord-254895-ym0jsir5	279	9	specific	specific	JJ
cord-254895-ym0jsir5	279	10	set	set	NN
cord-254895-ym0jsir5	279	11	of	of	IN
cord-254895-ym0jsir5	279	12	RNA	RNA	NNP
cord-254895-ym0jsir5	279	13	viruses	virus	NNS
cord-254895-ym0jsir5	279	14	belonging	belong	VBG
cord-254895-ym0jsir5	279	15	to	to	IN
cord-254895-ym0jsir5	279	16	Flaviviridae	Flaviviridae	NNP
cord-254895-ym0jsir5	279	17	,	,	,
cord-254895-ym0jsir5	279	18	Paramyxoviridae	Paramyxoviridae	NNP
cord-254895-ym0jsir5	279	19	,	,	,
cord-254895-ym0jsir5	279	20	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-254895-ym0jsir5	279	21	and	and	CC
cord-254895-ym0jsir5	279	22	Rhabdoviridae	Rhabdoviridae	NNP
cord-254895-ym0jsir5	279	23	Sumpter	Sumpter	NNP
cord-254895-ym0jsir5	279	24	et	et	NNP
cord-254895-ym0jsir5	279	25	al	al	NNP
cord-254895-ym0jsir5	279	26	.	.	.
cord-254895-ym0jsir5	280	1	,	,	,
cord-254895-ym0jsir5	280	2	2005	2005	CD
cord-254895-ym0jsir5	280	3	;	;	:
cord-254895-ym0jsir5	280	4	Yoneyama	Yoneyama	NNP
cord-254895-ym0jsir5	280	5	et	et	NNP
cord-254895-ym0jsir5	280	6	al	al	NNP
cord-254895-ym0jsir5	280	7	.	.	NNP
cord-254895-ym0jsir5	280	8	,	,	,
cord-254895-ym0jsir5	280	9	2004	2004	CD
cord-254895-ym0jsir5	280	10	)	)	-RRB-
cord-254895-ym0jsir5	280	11	.	.	.
cord-254895-ym0jsir5	281	1	Since	since	IN
cord-254895-ym0jsir5	281	2	RNA	RNA	NNP
cord-254895-ym0jsir5	281	3	is	be	VBZ
cord-254895-ym0jsir5	281	4	a	a	DT
cord-254895-ym0jsir5	281	5	fundamental	fundamental	JJ
cord-254895-ym0jsir5	281	6	entity	entity	NN
cord-254895-ym0jsir5	281	7	of	of	IN
cord-254895-ym0jsir5	281	8	most	most	JJS
cord-254895-ym0jsir5	281	9	living	live	VBG
cord-254895-ym0jsir5	281	10	organisms	organism	NNS
cord-254895-ym0jsir5	281	11	and	and	CC
cord-254895-ym0jsir5	281	12	is	be	VBZ
cord-254895-ym0jsir5	281	13	found	find	VBN
cord-254895-ym0jsir5	281	14	in	in	IN
cord-254895-ym0jsir5	281	15	abundance	abundance	NN
cord-254895-ym0jsir5	281	16	in	in	IN
cord-254895-ym0jsir5	281	17	host	host	NN
cord-254895-ym0jsir5	281	18	cells	cell	NNS
cord-254895-ym0jsir5	281	19	,	,	,
cord-254895-ym0jsir5	281	20	a	a	DT
cord-254895-ym0jsir5	281	21	molecular	molecular	JJ
cord-254895-ym0jsir5	281	22	pattern	pattern	NN
cord-254895-ym0jsir5	281	23	must	must	MD
cord-254895-ym0jsir5	281	24	exist	exist	VB
cord-254895-ym0jsir5	281	25	that	that	WDT
cord-254895-ym0jsir5	281	26	enables	enable	VBZ
cord-254895-ym0jsir5	281	27	RIG	rig	NN
cord-254895-ym0jsir5	281	28	-	-	:
cord-254895-ym0jsir5	281	29	I	-PRON-	PRP
cord-254895-ym0jsir5	281	30	to	to	TO
cord-254895-ym0jsir5	281	31	discriminate	discriminate	VB
cord-254895-ym0jsir5	281	32	between	between	IN
cord-254895-ym0jsir5	281	33	viral	viral	JJ
cord-254895-ym0jsir5	281	34	RNA	RNA	NNP
cord-254895-ym0jsir5	281	35	and	and	CC
cord-254895-ym0jsir5	281	36	host	host	NN
cord-254895-ym0jsir5	281	37	RNA	RNA	NNP
cord-254895-ym0jsir5	281	38	species	specie	NNS
cord-254895-ym0jsir5	281	39	in	in	IN
cord-254895-ym0jsir5	281	40	the	the	DT
cord-254895-ym0jsir5	281	41	cytoplasm	cytoplasm	NN
cord-254895-ym0jsir5	281	42	of	of	IN
cord-254895-ym0jsir5	281	43	infected	infected	JJ
cord-254895-ym0jsir5	281	44	cells	cell	NNS
cord-254895-ym0jsir5	281	45	to	to	TO
cord-254895-ym0jsir5	281	46	prevent	prevent	VB
cord-254895-ym0jsir5	281	47	constant	constant	JJ
cord-254895-ym0jsir5	281	48	induction	induction	NN
cord-254895-ym0jsir5	281	49	of	of	IN
cord-254895-ym0jsir5	281	50	type	type	NN
cord-254895-ym0jsir5	281	51	I	-PRON-	PRP
cord-254895-ym0jsir5	281	52	IFNs	ifns	VBP
cord-254895-ym0jsir5	281	53	which	which	WDT
cord-254895-ym0jsir5	281	54	would	would	MD
cord-254895-ym0jsir5	281	55	lead	lead	VB
cord-254895-ym0jsir5	281	56	to	to	IN
cord-254895-ym0jsir5	281	57	autoimmune	autoimmune	JJ
cord-254895-ym0jsir5	281	58	responses	response	NNS
cord-254895-ym0jsir5	281	59	.	.	.
cord-254895-ym0jsir5	282	1	Two	two	CD
cord-254895-ym0jsir5	282	2	recent	recent	JJ
cord-254895-ym0jsir5	282	3	studies	study	NNS
cord-254895-ym0jsir5	282	4	have	have	VBP
cord-254895-ym0jsir5	282	5	identified	identify	VBN
cord-254895-ym0jsir5	282	6	features	feature	NNS
cord-254895-ym0jsir5	282	7	of	of	IN
cord-254895-ym0jsir5	282	8	viral	viral	JJ
cord-254895-ym0jsir5	282	9	RNA	RNA	NNP
cord-254895-ym0jsir5	282	10	that	that	WDT
cord-254895-ym0jsir5	282	11	are	be	VBP
cord-254895-ym0jsir5	282	12	structurally	structurally	RB
cord-254895-ym0jsir5	282	13	different	different	JJ
cord-254895-ym0jsir5	282	14	to	to	TO
cord-254895-ym0jsir5	282	15	host	host	VB
cord-254895-ym0jsir5	282	16	RNA	RNA	NNP
cord-254895-ym0jsir5	282	17	.	.	.
cord-254895-ym0jsir5	283	1	Hornung	Hornung	NNP
cord-254895-ym0jsir5	283	2	et	et	NNP
cord-254895-ym0jsir5	283	3	al	al	NNP
cord-254895-ym0jsir5	283	4	.	.	.
cord-254895-ym0jsir5	284	1	(	(	-LRB-
cord-254895-ym0jsir5	284	2	2006	2006	CD
cord-254895-ym0jsir5	284	3	)	)	-RRB-
cord-254895-ym0jsir5	284	4	demonstrated	demonstrate	VBD
cord-254895-ym0jsir5	284	5	that	that	IN
cord-254895-ym0jsir5	284	6	ssRNA	ssRNA	VBG
cord-254895-ym0jsir5	284	7	synthesized	synthesize	VBN
cord-254895-ym0jsir5	284	8	in	in	IN
cord-254895-ym0jsir5	284	9	vitro	vitro	FW
cord-254895-ym0jsir5	284	10	acquires	acquire	VBZ
cord-254895-ym0jsir5	284	11	a	a	DT
cord-254895-ym0jsir5	284	12	5	5	CD
cord-254895-ym0jsir5	284	13	0	0	CD
cord-254895-ym0jsir5	284	14	-triphosphate	-triphosphate	NN
cord-254895-ym0jsir5	284	15	moiety	moiety	NN
cord-254895-ym0jsir5	284	16	which	which	WDT
cord-254895-ym0jsir5	284	17	is	be	VBZ
cord-254895-ym0jsir5	284	18	crucial	crucial	JJ
cord-254895-ym0jsir5	284	19	for	for	IN
cord-254895-ym0jsir5	284	20	IFN	IFN	NNP
cord-254895-ym0jsir5	284	21	production	production	NN
cord-254895-ym0jsir5	284	22	in	in	IN
cord-254895-ym0jsir5	284	23	host	host	NN
cord-254895-ym0jsir5	284	24	cells	cell	NNS
cord-254895-ym0jsir5	284	25	.	.	.
cord-254895-ym0jsir5	285	1	Furthermore	furthermore	RB
cord-254895-ym0jsir5	285	2	,	,	,
cord-254895-ym0jsir5	285	3	they	-PRON-	PRP
cord-254895-ym0jsir5	285	4	demonstrated	demonstrate	VBD
cord-254895-ym0jsir5	285	5	that	that	IN
cord-254895-ym0jsir5	285	6	RNA	RNA	NNP
cord-254895-ym0jsir5	285	7	isolated	isolate	VBN
cord-254895-ym0jsir5	285	8	from	from	IN
cord-254895-ym0jsir5	285	9	Rabies	Rabies	NNP
cord-254895-ym0jsir5	285	10	virus	virus	NN
cord-254895-ym0jsir5	285	11	(	(	-LRB-
cord-254895-ym0jsir5	285	12	RV	rv	NN
cord-254895-ym0jsir5	285	13	)	)	-RRB-
cord-254895-ym0jsir5	286	1	infected	infected	JJ
cord-254895-ym0jsir5	286	2	cells	cell	NNS
cord-254895-ym0jsir5	286	3	is	be	VBZ
cord-254895-ym0jsir5	286	4	a	a	DT
cord-254895-ym0jsir5	286	5	potent	potent	JJ
cord-254895-ym0jsir5	286	6	IFN	IFN	NNP
cord-254895-ym0jsir5	286	7	inducer	inducer	NN
cord-254895-ym0jsir5	286	8	,	,	,
cord-254895-ym0jsir5	286	9	whereas	whereas	IN
cord-254895-ym0jsir5	286	10	RNA	RNA	NNP
cord-254895-ym0jsir5	286	11	from	from	IN
cord-254895-ym0jsir5	286	12	non	non	JJ
cord-254895-ym0jsir5	286	13	-	-	JJ
cord-254895-ym0jsir5	286	14	infected	infected	JJ
cord-254895-ym0jsir5	286	15	cells	cell	NNS
cord-254895-ym0jsir5	286	16	and	and	CC
cord-254895-ym0jsir5	286	17	dephosphorylated	dephosphorylated	NNP
cord-254895-ym0jsir5	286	18	RNA	RNA	NNP
cord-254895-ym0jsir5	286	19	isolates	isolate	NNS
cord-254895-ym0jsir5	286	20	abrogated	abrogate	VBD
cord-254895-ym0jsir5	286	21	this	this	DT
cord-254895-ym0jsir5	286	22	IFN	IFN	NNP
cord-254895-ym0jsir5	286	23	response	response	NN
cord-254895-ym0jsir5	286	24	.	.	.
cord-254895-ym0jsir5	287	1	The	the	DT
cord-254895-ym0jsir5	287	2	5	5	CD
cord-254895-ym0jsir5	287	3	0	0	CD
cord-254895-ym0jsir5	287	4	-phosphorylation	-phosphorylation	CD
cord-254895-ym0jsir5	287	5	status	status	NN
cord-254895-ym0jsir5	287	6	and	and	CC
cord-254895-ym0jsir5	287	7	the	the	DT
cord-254895-ym0jsir5	287	8	absence	absence	NN
cord-254895-ym0jsir5	287	9	of	of	IN
cord-254895-ym0jsir5	287	10	a	a	DT
cord-254895-ym0jsir5	287	11	7-methyl	7-methyl	CD
cord-254895-ym0jsir5	287	12	-	-	HYPH
cord-254895-ym0jsir5	287	13	guanosine	guanosine	NN
cord-254895-ym0jsir5	287	14	cap	cap	NN
cord-254895-ym0jsir5	287	15	provided	provide	VBN
cord-254895-ym0jsir5	287	16	by	by	IN
cord-254895-ym0jsir5	287	17	the	the	DT
cord-254895-ym0jsir5	287	18	viral	viral	JJ
cord-254895-ym0jsir5	287	19	polymerase	polymerase	NN
cord-254895-ym0jsir5	287	20	is	be	VBZ
cord-254895-ym0jsir5	287	21	critical	critical	JJ
cord-254895-ym0jsir5	287	22	for	for	IN
cord-254895-ym0jsir5	287	23	recognition	recognition	NN
cord-254895-ym0jsir5	287	24	by	by	IN
cord-254895-ym0jsir5	288	1	RIG	rig	NN
cord-254895-ym0jsir5	288	2	-	-	HYPH
cord-254895-ym0jsir5	288	3	I.	i.	NN
cord-254895-ym0jsir5	288	4	Taken	take	VBN
cord-254895-ym0jsir5	288	5	together	together	RB
cord-254895-ym0jsir5	288	6	,	,	,
cord-254895-ym0jsir5	288	7	the	the	DT
cord-254895-ym0jsir5	288	8	results	result	NNS
cord-254895-ym0jsir5	288	9	of	of	IN
cord-254895-ym0jsir5	288	10	Hornung	Hornung	NNP
cord-254895-ym0jsir5	288	11	et	et	NNP
cord-254895-ym0jsir5	288	12	al	al	NNP
cord-254895-ym0jsir5	288	13	.	.	.
cord-254895-ym0jsir5	289	1	(	(	-LRB-
cord-254895-ym0jsir5	289	2	2006	2006	CD
cord-254895-ym0jsir5	289	3	)	)	-RRB-
cord-254895-ym0jsir5	289	4	show	show	VBP
cord-254895-ym0jsir5	289	5	that	that	IN
cord-254895-ym0jsir5	289	6	RIG	rig	NN
cord-254895-ym0jsir5	289	7	-	-	:
cord-254895-ym0jsir5	289	8	I	-PRON-	PRP
cord-254895-ym0jsir5	289	9	directly	directly	RB
cord-254895-ym0jsir5	289	10	recognizes	recognize	VBZ
cord-254895-ym0jsir5	289	11	5	5	CD
cord-254895-ym0jsir5	289	12	0	0	CD
cord-254895-ym0jsir5	289	13	-triphosphate	-triphosphate	NN
cord-254895-ym0jsir5	289	14	single	single	JJ
cord-254895-ym0jsir5	289	15	stranded	stranded	JJ
cord-254895-ym0jsir5	289	16	or	or	CC
cord-254895-ym0jsir5	289	17	double	double	JJ
cord-254895-ym0jsir5	289	18	stranded	strand	VBN
cord-254895-ym0jsir5	289	19	RNA	RNA	NNP
cord-254895-ym0jsir5	289	20	independently	independently	RB
cord-254895-ym0jsir5	289	21	of	of	IN
cord-254895-ym0jsir5	289	22	viral	viral	JJ
cord-254895-ym0jsir5	289	23	replication	replication	NN
cord-254895-ym0jsir5	289	24	.	.	.
cord-254895-ym0jsir5	290	1	In	in	IN
cord-254895-ym0jsir5	290	2	the	the	DT
cord-254895-ym0jsir5	290	3	second	second	JJ
cord-254895-ym0jsir5	290	4	study	study	NN
cord-254895-ym0jsir5	290	5	,	,	,
cord-254895-ym0jsir5	290	6	Pichlmair	Pichlmair	NNP
cord-254895-ym0jsir5	290	7	et	et	NNP
cord-254895-ym0jsir5	290	8	al	al	NNP
cord-254895-ym0jsir5	290	9	.	.	.
cord-254895-ym0jsir5	291	1	(	(	-LRB-
cord-254895-ym0jsir5	291	2	2006	2006	CD
cord-254895-ym0jsir5	291	3	)	)	-RRB-
cord-254895-ym0jsir5	291	4	found	find	VBD
cord-254895-ym0jsir5	291	5	that	that	IN
cord-254895-ym0jsir5	291	6	Influenza	Influenza	NNP
cord-254895-ym0jsir5	291	7	A	a	DT
cord-254895-ym0jsir5	291	8	virus	virus	NN
cord-254895-ym0jsir5	291	9	,	,	,
cord-254895-ym0jsir5	291	10	which	which	WDT
cord-254895-ym0jsir5	291	11	is	be	VBZ
cord-254895-ym0jsir5	291	12	known	know	VBN
cord-254895-ym0jsir5	291	13	to	to	TO
cord-254895-ym0jsir5	291	14	be	be	VB
cord-254895-ym0jsir5	291	15	sensed	sense	VBN
cord-254895-ym0jsir5	291	16	by	by	IN
cord-254895-ym0jsir5	291	17	both	both	DT
cord-254895-ym0jsir5	291	18	RIG	rig	NN
cord-254895-ym0jsir5	291	19	-	-	:
cord-254895-ym0jsir5	291	20	I	I	NNP
cord-254895-ym0jsir5	291	21	and	and	CC
cord-254895-ym0jsir5	291	22	TLR3	TLR3	NNP
cord-254895-ym0jsir5	291	23	,	,	,
cord-254895-ym0jsir5	291	24	did	do	VBD
cord-254895-ym0jsir5	291	25	not	not	RB
cord-254895-ym0jsir5	291	26	generate	generate	VB
cord-254895-ym0jsir5	291	27	dsRNA	dsrna	NN
cord-254895-ym0jsir5	291	28	upon	upon	IN
cord-254895-ym0jsir5	291	29	infection	infection	NN
cord-254895-ym0jsir5	291	30	of	of	IN
cord-254895-ym0jsir5	291	31	bone	bone	NN
cord-254895-ym0jsir5	291	32	-	-	HYPH
cord-254895-ym0jsir5	291	33	marrow	marrow	NN
cord-254895-ym0jsir5	291	34	-	-	HYPH
cord-254895-ym0jsir5	291	35	derived	derive	VBN
cord-254895-ym0jsir5	291	36	dendritic	dendritic	JJ
cord-254895-ym0jsir5	291	37	cells	cell	NNS
cord-254895-ym0jsir5	291	38	.	.	.
cord-254895-ym0jsir5	292	1	Moreover	moreover	RB
cord-254895-ym0jsir5	292	2	,	,	,
cord-254895-ym0jsir5	292	3	they	-PRON-	PRP
cord-254895-ym0jsir5	292	4	observed	observe	VBD
cord-254895-ym0jsir5	292	5	that	that	IN
cord-254895-ym0jsir5	292	6	Influenza	Influenza	NNP
cord-254895-ym0jsir5	292	7	virus	virus	NN
cord-254895-ym0jsir5	292	8	ssRNA	ssrna	NN
cord-254895-ym0jsir5	292	9	,	,	,
cord-254895-ym0jsir5	292	10	which	which	WDT
cord-254895-ym0jsir5	292	11	is	be	VBZ
cord-254895-ym0jsir5	292	12	uncapped	uncapped	JJ
cord-254895-ym0jsir5	292	13	and	and	CC
cord-254895-ym0jsir5	292	14	bears	bear	VBZ
cord-254895-ym0jsir5	292	15	5	5	CD
cord-254895-ym0jsir5	292	16	0	0	CD
cord-254895-ym0jsir5	292	17	-triphosphates	-triphosphate	NNS
cord-254895-ym0jsir5	292	18	,	,	,
cord-254895-ym0jsir5	292	19	associated	associate	VBN
cord-254895-ym0jsir5	292	20	with	with	IN
cord-254895-ym0jsir5	292	21	and	and	CC
cord-254895-ym0jsir5	292	22	activated	activate	VBN
cord-254895-ym0jsir5	292	23	RIG	rig	NN
cord-254895-ym0jsir5	292	24	-	-	HYPH
cord-254895-ym0jsir5	292	25	I.	I.	NNP
cord-254895-ym0jsir5	292	26	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	292	27	functions	function	NNS
cord-254895-ym0jsir5	292	28	as	as	IN
cord-254895-ym0jsir5	292	29	critical	critical	JJ
cord-254895-ym0jsir5	292	30	link	link	NN
cord-254895-ym0jsir5	292	31	between	between	IN
cord-254895-ym0jsir5	292	32	viral	viral	JJ
cord-254895-ym0jsir5	292	33	detection	detection	NN
cord-254895-ym0jsir5	292	34	by	by	IN
cord-254895-ym0jsir5	292	35	RIG	rig	NN
cord-254895-ym0jsir5	292	36	-	-	:
cord-254895-ym0jsir5	292	37	I	I	NNP
cord-254895-ym0jsir5	292	38	and	and	CC
cord-254895-ym0jsir5	292	39	the	the	DT
cord-254895-ym0jsir5	292	40	downstream	downstream	JJ
cord-254895-ym0jsir5	292	41	signaling	signal	VBG
cord-254895-ym0jsir5	292	42	events	event	NNS
cord-254895-ym0jsir5	292	43	leading	lead	VBG
cord-254895-ym0jsir5	292	44	to	to	IN
cord-254895-ym0jsir5	292	45	interferon	interferon	NN
cord-254895-ym0jsir5	292	46	production	production	NN
cord-254895-ym0jsir5	292	47	.	.	.
cord-254895-ym0jsir5	293	1	This	this	DT
cord-254895-ym0jsir5	293	2	receptor	receptor	NN
cord-254895-ym0jsir5	293	3	-	-	HYPH
cord-254895-ym0jsir5	293	4	adapter	adapter	NN
cord-254895-ym0jsir5	293	5	interaction	interaction	NN
cord-254895-ym0jsir5	293	6	results	result	NNS
cord-254895-ym0jsir5	293	7	in	in	IN
cord-254895-ym0jsir5	293	8	the	the	DT
cord-254895-ym0jsir5	293	9	activation	activation	NN
cord-254895-ym0jsir5	293	10	of	of	IN
cord-254895-ym0jsir5	293	11	the	the	DT
cord-254895-ym0jsir5	293	12	noncanonical	noncanonical	JJ
cord-254895-ym0jsir5	293	13	kinases	kinase	NNS
cord-254895-ym0jsir5	293	14	TBK1	TBK1	NNP
cord-254895-ym0jsir5	293	15	/	/	SYM
cord-254895-ym0jsir5	293	16	IKKe	IKKe	NNS
cord-254895-ym0jsir5	293	17	,	,	,
cord-254895-ym0jsir5	293	18	which	which	WDT
cord-254895-ym0jsir5	293	19	in	in	IN
cord-254895-ym0jsir5	293	20	turn	turn	NN
cord-254895-ym0jsir5	293	21	induces	induce	VBZ
cord-254895-ym0jsir5	293	22	dimerization	dimerization	NN
cord-254895-ym0jsir5	293	23	of	of	IN
cord-254895-ym0jsir5	293	24	phosphorylated	phosphorylated	JJ
cord-254895-ym0jsir5	293	25	IRF3	IRF3	NNP
cord-254895-ym0jsir5	293	26	and	and	CC
cord-254895-ym0jsir5	293	27	IRF7	IRF7	NNP
cord-254895-ym0jsir5	293	28	and	and	CC
cord-254895-ym0jsir5	293	29	translocation	translocation	NN
cord-254895-ym0jsir5	293	30	to	to	IN
cord-254895-ym0jsir5	293	31	the	the	DT
cord-254895-ym0jsir5	293	32	nucleus	nucleus	NN
cord-254895-ym0jsir5	293	33	where	where	WRB
cord-254895-ym0jsir5	293	34	they	-PRON-	PRP
cord-254895-ym0jsir5	293	35	activate	activate	VBP
cord-254895-ym0jsir5	293	36	the	the	DT
cord-254895-ym0jsir5	293	37	transcription	transcription	NN
cord-254895-ym0jsir5	293	38	of	of	IN
cord-254895-ym0jsir5	293	39	type	type	NN
cord-254895-ym0jsir5	293	40	I	-PRON-	PRP
cord-254895-ym0jsir5	293	41	IFN	IFN	NNP
cord-254895-ym0jsir5	293	42	genes	gene	NNS
cord-254895-ym0jsir5	293	43	.	.	.
cord-254895-ym0jsir5	294	1	Coimmunoprecipitation	coimmunoprecipitation	NN
cord-254895-ym0jsir5	294	2	experiments	experiment	NNS
cord-254895-ym0jsir5	294	3	suggest	suggest	VBP
cord-254895-ym0jsir5	294	4	that	that	IN
cord-254895-ym0jsir5	294	5	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	294	6	interacts	interact	VBZ
cord-254895-ym0jsir5	294	7	with	with	IN
cord-254895-ym0jsir5	294	8	TBK1	TBK1	NNP
cord-254895-ym0jsir5	294	9	and	and	CC
cord-254895-ym0jsir5	294	10	recruits	recruit	VBZ
cord-254895-ym0jsir5	294	11	endogenous	endogenous	JJ
cord-254895-ym0jsir5	294	12	IRF3	IRF3	NNP
cord-254895-ym0jsir5	294	13	in	in	IN
cord-254895-ym0jsir5	294	14	a	a	DT
cord-254895-ym0jsir5	294	15	virus	virus	NN
cord-254895-ym0jsir5	294	16	-	-	HYPH
cord-254895-ym0jsir5	294	17	inducible	inducible	JJ
cord-254895-ym0jsir5	294	18	manner	manner	NN
cord-254895-ym0jsir5	294	19	(	(	-LRB-
cord-254895-ym0jsir5	294	20	Xu	Xu	NNP
cord-254895-ym0jsir5	294	21	et	et	NNP
cord-254895-ym0jsir5	294	22	al	al	NNP
cord-254895-ym0jsir5	294	23	.	.	NNP
cord-254895-ym0jsir5	294	24	,	,	,
cord-254895-ym0jsir5	294	25	2005	2005	CD
cord-254895-ym0jsir5	294	26	)	)	-RRB-
cord-254895-ym0jsir5	294	27	.	.	.
cord-254895-ym0jsir5	295	1	Recently	recently	RB
cord-254895-ym0jsir5	295	2	,	,	,
cord-254895-ym0jsir5	295	3	TRAF3	TRAF3	NNP
cord-254895-ym0jsir5	295	4	was	be	VBD
cord-254895-ym0jsir5	295	5	shown	show	VBN
cord-254895-ym0jsir5	295	6	to	to	TO
cord-254895-ym0jsir5	295	7	be	be	VB
cord-254895-ym0jsir5	295	8	critically	critically	RB
cord-254895-ym0jsir5	295	9	involved	involve	VBN
cord-254895-ym0jsir5	295	10	in	in	IN
cord-254895-ym0jsir5	295	11	IPS-1-mediated	ips-1-mediate	VBN
cord-254895-ym0jsir5	295	12	IFN	IFN	NNP
cord-254895-ym0jsir5	295	13	-	-	:
cord-254895-ym0jsir5	295	14	a	a	DT
cord-254895-ym0jsir5	295	15	production	production	NN
cord-254895-ym0jsir5	295	16	and	and	CC
cord-254895-ym0jsir5	295	17	antiviral	antiviral	JJ
cord-254895-ym0jsir5	295	18	responses	response	NNS
cord-254895-ym0jsir5	295	19	through	through	IN
cord-254895-ym0jsir5	295	20	a	a	DT
cord-254895-ym0jsir5	295	21	direct	direct	JJ
cord-254895-ym0jsir5	295	22	interaction	interaction	NN
cord-254895-ym0jsir5	295	23	between	between	IN
cord-254895-ym0jsir5	295	24	the	the	DT
cord-254895-ym0jsir5	295	25	TRAF	TRAF	NNP
cord-254895-ym0jsir5	295	26	domain	domain	NN
cord-254895-ym0jsir5	295	27	of	of	IN
cord-254895-ym0jsir5	295	28	TRAF3	traf3	NN
cord-254895-ym0jsir5	295	29	and	and	CC
cord-254895-ym0jsir5	295	30	a	a	DT
cord-254895-ym0jsir5	295	31	TRAF	TRAF	NNP
cord-254895-ym0jsir5	295	32	interaction	interaction	NN
cord-254895-ym0jsir5	295	33	motif	motif	NN
cord-254895-ym0jsir5	295	34	within	within	IN
cord-254895-ym0jsir5	295	35	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	296	1	(	(	-LRB-
cord-254895-ym0jsir5	296	2	Saha	Saha	NNP
cord-254895-ym0jsir5	296	3	et	et	NNP
cord-254895-ym0jsir5	296	4	al	al	NNP
cord-254895-ym0jsir5	296	5	.	.	NNP
cord-254895-ym0jsir5	296	6	,	,	,
cord-254895-ym0jsir5	296	7	2006	2006	CD
cord-254895-ym0jsir5	296	8	)	)	-RRB-
cord-254895-ym0jsir5	296	9	.	.	.
cord-254895-ym0jsir5	297	1	There	there	EX
cord-254895-ym0jsir5	297	2	is	be	VBZ
cord-254895-ym0jsir5	297	3	evidence	evidence	NN
cord-254895-ym0jsir5	297	4	that	that	IN
cord-254895-ym0jsir5	297	5	the	the	DT
cord-254895-ym0jsir5	297	6	TBK1	TBK1	NNP
cord-254895-ym0jsir5	297	7	/	/	SYM
cord-254895-ym0jsir5	297	8	IKKe	IKKe	NNP
cord-254895-ym0jsir5	297	9	adaptor	adaptor	NN
cord-254895-ym0jsir5	297	10	protein	protein	NN
cord-254895-ym0jsir5	297	11	TANK	tank	NN
cord-254895-ym0jsir5	297	12	plays	play	VBZ
cord-254895-ym0jsir5	297	13	a	a	DT
cord-254895-ym0jsir5	297	14	role	role	NN
cord-254895-ym0jsir5	297	15	in	in	IN
cord-254895-ym0jsir5	297	16	IPS-1-TRAF3-mediated	IPS-1-TRAF3-mediated	NNP
cord-254895-ym0jsir5	297	17	activation	activation	NN
cord-254895-ym0jsir5	297	18	of	of	IN
cord-254895-ym0jsir5	297	19	TBK1	TBK1	NNP
cord-254895-ym0jsir5	297	20	/	/	SYM
cord-254895-ym0jsir5	297	21	IKKe	IKKe	NNS
cord-254895-ym0jsir5	297	22	(	(	-LRB-
cord-254895-ym0jsir5	297	23	Guo	Guo	NNP
cord-254895-ym0jsir5	297	24	and	and	CC
cord-254895-ym0jsir5	297	25	Cheng	Cheng	NNP
cord-254895-ym0jsir5	297	26	,	,	,
cord-254895-ym0jsir5	297	27	2007	2007	CD
cord-254895-ym0jsir5	297	28	)	)	-RRB-
cord-254895-ym0jsir5	297	29	.	.	.
cord-254895-ym0jsir5	298	1	RIP1	RIP1	NNP
cord-254895-ym0jsir5	298	2	and	and	CC
cord-254895-ym0jsir5	298	3	FADD	FADD	NNP
cord-254895-ym0jsir5	298	4	are	be	VBP
cord-254895-ym0jsir5	298	5	additional	additional	JJ
cord-254895-ym0jsir5	298	6	molecules	molecule	NNS
cord-254895-ym0jsir5	298	7	that	that	WDT
cord-254895-ym0jsir5	298	8	have	have	VBP
cord-254895-ym0jsir5	298	9	been	be	VBN
cord-254895-ym0jsir5	298	10	reported	report	VBN
cord-254895-ym0jsir5	298	11	to	to	TO
cord-254895-ym0jsir5	298	12	be	be	VB
cord-254895-ym0jsir5	298	13	required	require	VBN
cord-254895-ym0jsir5	298	14	for	for	IN
cord-254895-ym0jsir5	298	15	type	type	NN
cord-254895-ym0jsir5	299	1	I	-PRON-	PRP
cord-254895-ym0jsir5	299	2	IFN	IFN	NNP
cord-254895-ym0jsir5	299	3	production	production	NN
cord-254895-ym0jsir5	299	4	in	in	IN
cord-254895-ym0jsir5	299	5	response	response	NN
cord-254895-ym0jsir5	299	6	to	to	IN
cord-254895-ym0jsir5	299	7	dsRNA	dsrna	NN
cord-254895-ym0jsir5	300	1	(	(	-LRB-
cord-254895-ym0jsir5	300	2	Balachandran	Balachandran	NNP
cord-254895-ym0jsir5	300	3	et	et	NNP
cord-254895-ym0jsir5	300	4	al	al	NNP
cord-254895-ym0jsir5	300	5	.	.	NNP
cord-254895-ym0jsir5	300	6	,	,	,
cord-254895-ym0jsir5	300	7	2004	2004	CD
cord-254895-ym0jsir5	300	8	)	)	-RRB-
cord-254895-ym0jsir5	300	9	.	.	.
cord-254895-ym0jsir5	301	1	Another	another	DT
cord-254895-ym0jsir5	301	2	branch	branch	NN
cord-254895-ym0jsir5	301	3	of	of	IN
cord-254895-ym0jsir5	301	4	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	301	5	signaling	signal	VBG
cord-254895-ym0jsir5	301	6	leads	lead	VBZ
cord-254895-ym0jsir5	301	7	to	to	IN
cord-254895-ym0jsir5	301	8	the	the	DT
cord-254895-ym0jsir5	301	9	activation	activation	NN
cord-254895-ym0jsir5	301	10	of	of	IN
cord-254895-ym0jsir5	301	11	the	the	DT
cord-254895-ym0jsir5	301	12	IKK	IKK	NNP
cord-254895-ym0jsir5	301	13	complex	complex	NN
cord-254895-ym0jsir5	301	14	resulting	result	VBG
cord-254895-ym0jsir5	301	15	in	in	IN
cord-254895-ym0jsir5	301	16	activation	activation	NN
cord-254895-ym0jsir5	301	17	of	of	IN
cord-254895-ym0jsir5	301	18	NFkB	nfkb	UH
cord-254895-ym0jsir5	301	19	that	that	WDT
cord-254895-ym0jsir5	301	20	controls	control	VBZ
cord-254895-ym0jsir5	301	21	the	the	DT
cord-254895-ym0jsir5	301	22	expression	expression	NN
cord-254895-ym0jsir5	301	23	of	of	IN
cord-254895-ym0jsir5	301	24	genes	gene	NNS
cord-254895-ym0jsir5	301	25	encoding	encode	VBG
cord-254895-ym0jsir5	301	26	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	301	27	responses	response	NNS
cord-254895-ym0jsir5	301	28	,	,	,
cord-254895-ym0jsir5	301	29	but	but	CC
cord-254895-ym0jsir5	301	30	also	also	RB
cord-254895-ym0jsir5	301	31	expression	expression	NN
cord-254895-ym0jsir5	301	32	of	of	IN
cord-254895-ym0jsir5	301	33	IFN	IFN	NNP
cord-254895-ym0jsir5	301	34	-	-	HYPH
cord-254895-ym0jsir5	301	35	b	b	NNP
cord-254895-ym0jsir5	301	36	.	.	.
cord-254895-ym0jsir5	302	1	Previous	previous	JJ
cord-254895-ym0jsir5	302	2	work	work	NN
cord-254895-ym0jsir5	302	3	showed	show	VBD
cord-254895-ym0jsir5	302	4	that	that	IN
cord-254895-ym0jsir5	302	5	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	302	6	activates	activate	VBZ
cord-254895-ym0jsir5	302	7	a	a	DT
cord-254895-ym0jsir5	302	8	NFkBdependent	nfkbdependent	NN
cord-254895-ym0jsir5	302	9	reporter	reporter	NN
cord-254895-ym0jsir5	302	10	construct	construct	VB
cord-254895-ym0jsir5	302	11	in	in	IN
cord-254895-ym0jsir5	302	12	cultured	cultured	JJ
cord-254895-ym0jsir5	302	13	cells	cell	NNS
cord-254895-ym0jsir5	302	14	(	(	-LRB-
cord-254895-ym0jsir5	302	15	Matsuda	Matsuda	NNP
cord-254895-ym0jsir5	302	16	et	et	FW
cord-254895-ym0jsir5	302	17	al	al	NNP
cord-254895-ym0jsir5	302	18	.	.	NNP
cord-254895-ym0jsir5	302	19	,	,	,
cord-254895-ym0jsir5	302	20	2003	2003	CD
cord-254895-ym0jsir5	302	21	)	)	-RRB-
cord-254895-ym0jsir5	302	22	.	.	.
cord-254895-ym0jsir5	303	1	One	one	CD
cord-254895-ym0jsir5	303	2	of	of	IN
cord-254895-ym0jsir5	303	3	the	the	DT
cord-254895-ym0jsir5	303	4	key	key	JJ
cord-254895-ym0jsir5	303	5	signaling	signal	VBG
cord-254895-ym0jsir5	303	6	proteins	protein	NNS
cord-254895-ym0jsir5	303	7	in	in	IN
cord-254895-ym0jsir5	303	8	the	the	DT
cord-254895-ym0jsir5	303	9	NFkB	NFkB	NNP
cord-254895-ym0jsir5	303	10	pathway	pathway	NN
cord-254895-ym0jsir5	303	11	is	be	VBZ
cord-254895-ym0jsir5	303	12	TRAF6	TRAF6	NNP
cord-254895-ym0jsir5	303	13	,	,	,
cord-254895-ym0jsir5	303	14	an	an	DT
cord-254895-ym0jsir5	303	15	essential	essential	JJ
cord-254895-ym0jsir5	303	16	upstream	upstream	JJ
cord-254895-ym0jsir5	303	17	regulator	regulator	NN
cord-254895-ym0jsir5	303	18	of	of	IN
cord-254895-ym0jsir5	303	19	the	the	DT
cord-254895-ym0jsir5	303	20	IKK	IKK	NNP
cord-254895-ym0jsir5	303	21	complex	complex	NN
cord-254895-ym0jsir5	303	22	.	.	.
cord-254895-ym0jsir5	304	1	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	304	2	binds	bind	VBZ
cord-254895-ym0jsir5	304	3	to	to	IN
cord-254895-ym0jsir5	304	4	TRAF6	traf6	RB
cord-254895-ym0jsir5	304	5	upon	upon	IN
cord-254895-ym0jsir5	304	6	overexpression	overexpression	NN
cord-254895-ym0jsir5	304	7	in	in	IN
cord-254895-ym0jsir5	304	8	mammalian	mammalian	JJ
cord-254895-ym0jsir5	304	9	cells	cell	NNS
cord-254895-ym0jsir5	304	10	and	and	CC
cord-254895-ym0jsir5	304	11	in	in	IN
cord-254895-ym0jsir5	304	12	a	a	DT
cord-254895-ym0jsir5	304	13	yeasttwo	yeasttwo	CD
cord-254895-ym0jsir5	304	14	hybrid	hybrid	NN
cord-254895-ym0jsir5	304	15	screen	screen	NN
cord-254895-ym0jsir5	304	16	Xu	Xu	NNP
cord-254895-ym0jsir5	304	17	et	et	NNP
cord-254895-ym0jsir5	304	18	al	al	NNP
cord-254895-ym0jsir5	304	19	.	.	NNP
cord-254895-ym0jsir5	304	20	,	,	,
cord-254895-ym0jsir5	304	21	2005	2005	CD
cord-254895-ym0jsir5	304	22	)	)	-RRB-
cord-254895-ym0jsir5	304	23	.	.	.
cord-254895-ym0jsir5	305	1	Xu	Xu	NNP
cord-254895-ym0jsir5	305	2	et	et	NNP
cord-254895-ym0jsir5	305	3	al	al	NNP
cord-254895-ym0jsir5	305	4	.	.	.
cord-254895-ym0jsir5	306	1	(	(	-LRB-
cord-254895-ym0jsir5	306	2	2005	2005	CD
cord-254895-ym0jsir5	306	3	)	)	-RRB-
cord-254895-ym0jsir5	306	4	reported	report	VBD
cord-254895-ym0jsir5	306	5	that	that	IN
cord-254895-ym0jsir5	306	6	endogenous	endogenous	JJ
cord-254895-ym0jsir5	306	7	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	306	8	also	also	RB
cord-254895-ym0jsir5	306	9	interacts	interact	VBZ
cord-254895-ym0jsir5	306	10	with	with	IN
cord-254895-ym0jsir5	306	11	TRAF6	TRAF6	NNP
cord-254895-ym0jsir5	306	12	.	.	.
cord-254895-ym0jsir5	307	1	In	in	IN
cord-254895-ym0jsir5	307	2	addition	addition	NN
cord-254895-ym0jsir5	307	3	,	,	,
cord-254895-ym0jsir5	307	4	they	-PRON-	PRP
cord-254895-ym0jsir5	307	5	showed	show	VBD
cord-254895-ym0jsir5	307	6	that	that	IN
cord-254895-ym0jsir5	307	7	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	307	8	fails	fail	VBZ
cord-254895-ym0jsir5	307	9	to	to	TO
cord-254895-ym0jsir5	307	10	activate	activate	VB
cord-254895-ym0jsir5	307	11	NFkB	NFkB	NNP
cord-254895-ym0jsir5	307	12	in	in	IN
cord-254895-ym0jsir5	307	13	the	the	DT
cord-254895-ym0jsir5	307	14	absence	absence	NN
cord-254895-ym0jsir5	307	15	of	of	IN
cord-254895-ym0jsir5	307	16	TRAF6	traf6	NN
cord-254895-ym0jsir5	307	17	.	.	.
cord-254895-ym0jsir5	308	1	Seth	Seth	NNP
cord-254895-ym0jsir5	308	2	et	et	NNP
cord-254895-ym0jsir5	308	3	al	al	NNP
cord-254895-ym0jsir5	308	4	.	.	.
cord-254895-ym0jsir5	309	1	(	(	-LRB-
cord-254895-ym0jsir5	309	2	2005	2005	CD
cord-254895-ym0jsir5	309	3	)	)	-RRB-
cord-254895-ym0jsir5	309	4	reported	report	VBD
cord-254895-ym0jsir5	309	5	that	that	IN
cord-254895-ym0jsir5	309	6	virus	virus	NN
cord-254895-ym0jsir5	309	7	-	-	HYPH
cord-254895-ym0jsir5	309	8	mediated	mediate	VBN
cord-254895-ym0jsir5	309	9	induction	induction	NN
cord-254895-ym0jsir5	309	10	of	of	IN
cord-254895-ym0jsir5	309	11	the	the	DT
cord-254895-ym0jsir5	309	12	IFN	IFN	NNP
cord-254895-ym0jsir5	309	13	-	-	HYPH
cord-254895-ym0jsir5	309	14	b	b	NN
cord-254895-ym0jsir5	309	15	gene	gene	NN
cord-254895-ym0jsir5	309	16	is	be	VBZ
cord-254895-ym0jsir5	309	17	not	not	RB
cord-254895-ym0jsir5	309	18	abolished	abolish	VBN
cord-254895-ym0jsir5	309	19	in	in	IN
cord-254895-ym0jsir5	309	20	TRAF6	traf6	FW
cord-254895-ym0jsir5	309	21	deficient	deficient	JJ
cord-254895-ym0jsir5	309	22	cells	cell	NNS
cord-254895-ym0jsir5	309	23	and	and	CC
cord-254895-ym0jsir5	309	24	that	that	IN
cord-254895-ym0jsir5	309	25	a	a	DT
cord-254895-ym0jsir5	309	26	mutant	mutant	JJ
cord-254895-ym0jsir5	309	27	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	309	28	protein	protein	NN
cord-254895-ym0jsir5	309	29	lacking	lack	VBG
cord-254895-ym0jsir5	309	30	the	the	DT
cord-254895-ym0jsir5	309	31	TRAF6	traf6	NN
cord-254895-ym0jsir5	309	32	binding	binding	NN
cord-254895-ym0jsir5	309	33	domain	domain	NN
cord-254895-ym0jsir5	309	34	is	be	VBZ
cord-254895-ym0jsir5	309	35	still	still	RB
cord-254895-ym0jsir5	309	36	capable	capable	JJ
cord-254895-ym0jsir5	309	37	of	of	IN
cord-254895-ym0jsir5	309	38	inducing	induce	VBG
cord-254895-ym0jsir5	309	39	IFN	IFN	NNP
cord-254895-ym0jsir5	309	40	-	-	HYPH
cord-254895-ym0jsir5	309	41	b	b	NNP
cord-254895-ym0jsir5	309	42	.	.	.
cord-254895-ym0jsir5	310	1	Thus	thus	RB
cord-254895-ym0jsir5	310	2	,	,	,
cord-254895-ym0jsir5	310	3	TRAF6	TRAF6	NNP
cord-254895-ym0jsir5	310	4	seems	seem	VBZ
cord-254895-ym0jsir5	310	5	to	to	TO
cord-254895-ym0jsir5	310	6	be	be	VB
cord-254895-ym0jsir5	310	7	required	require	VBN
cord-254895-ym0jsir5	310	8	for	for	IN
cord-254895-ym0jsir5	310	9	NFkB	NFkB	NNP
cord-254895-ym0jsir5	310	10	activation	activation	NN
cord-254895-ym0jsir5	310	11	but	but	CC
cord-254895-ym0jsir5	310	12	not	not	RB
cord-254895-ym0jsir5	310	13	IFN	IFN	NNP
cord-254895-ym0jsir5	310	14	-	-	HYPH
cord-254895-ym0jsir5	310	15	b	b	NN
cord-254895-ym0jsir5	310	16	induction	induction	NN
cord-254895-ym0jsir5	310	17	downstream	downstream	NN
cord-254895-ym0jsir5	310	18	of	of	IN
cord-254895-ym0jsir5	310	19	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	310	20	which	which	WDT
cord-254895-ym0jsir5	310	21	is	be	VBZ
cord-254895-ym0jsir5	310	22	mainly	mainly	RB
cord-254895-ym0jsir5	310	23	mediated	mediate	VBN
cord-254895-ym0jsir5	310	24	by	by	IN
cord-254895-ym0jsir5	310	25	TBK1	TBK1	NNP
cord-254895-ym0jsir5	310	26	/	/	SYM
cord-254895-ym0jsir5	310	27	IKKe	IKKe	NNS
cord-254895-ym0jsir5	310	28	.	.	.
cord-254895-ym0jsir5	311	1	In	in	IN
cord-254895-ym0jsir5	311	2	vitro	vitro	FW
cord-254895-ym0jsir5	311	3	studies	study	NNS
cord-254895-ym0jsir5	311	4	performed	perform	VBN
cord-254895-ym0jsir5	311	5	with	with	IN
cord-254895-ym0jsir5	311	6	primary	primary	JJ
cord-254895-ym0jsir5	311	7	cells	cell	NNS
cord-254895-ym0jsir5	311	8	obtained	obtain	VBN
cord-254895-ym0jsir5	311	9	from	from	IN
cord-254895-ym0jsir5	311	10	RIG	rig	NN
cord-254895-ym0jsir5	311	11	-	-	HYPH
cord-254895-ym0jsir5	311	12	I	i	NN
cord-254895-ym0jsir5	311	13	knockout	knockout	NN
cord-254895-ym0jsir5	311	14	mice	mouse	NNS
cord-254895-ym0jsir5	311	15	confirmed	confirm	VBD
cord-254895-ym0jsir5	311	16	that	that	IN
cord-254895-ym0jsir5	311	17	RIG	rig	NN
cord-254895-ym0jsir5	311	18	-	-	:
cord-254895-ym0jsir5	311	19	I	-PRON-	PRP
cord-254895-ym0jsir5	311	20	plays	play	VBZ
cord-254895-ym0jsir5	311	21	an	an	DT
cord-254895-ym0jsir5	311	22	essential	essential	JJ
cord-254895-ym0jsir5	311	23	role	role	NN
cord-254895-ym0jsir5	311	24	in	in	IN
cord-254895-ym0jsir5	311	25	eliciting	elicit	VBG
cord-254895-ym0jsir5	311	26	immune	immune	JJ
cord-254895-ym0jsir5	311	27	responses	response	NNS
cord-254895-ym0jsir5	311	28	against	against	IN
cord-254895-ym0jsir5	311	29	specific	specific	JJ
cord-254895-ym0jsir5	311	30	negative	negative	JJ
cord-254895-ym0jsir5	311	31	strand	strand	NN
cord-254895-ym0jsir5	311	32	and	and	CC
cord-254895-ym0jsir5	311	33	positive	positive	JJ
cord-254895-ym0jsir5	311	34	strand	strand	NN
cord-254895-ym0jsir5	311	35	RNA	RNA	NNP
cord-254895-ym0jsir5	311	36	viruses	virus	NNS
cord-254895-ym0jsir5	311	37	such	such	JJ
cord-254895-ym0jsir5	311	38	as	as	IN
cord-254895-ym0jsir5	311	39	NDV	NDV	NNP
cord-254895-ym0jsir5	311	40	,	,	,
cord-254895-ym0jsir5	311	41	SeV	sev	NN
cord-254895-ym0jsir5	311	42	,	,	,
cord-254895-ym0jsir5	311	43	VSV	VSV	NNP
cord-254895-ym0jsir5	311	44	,	,	,
cord-254895-ym0jsir5	311	45	Japanese	japanese	JJ
cord-254895-ym0jsir5	311	46	encephalitis	encephalitis	RB
cord-254895-ym0jsir5	311	47	virus	virus	NN
cord-254895-ym0jsir5	311	48	(	(	-LRB-
cord-254895-ym0jsir5	311	49	JEV	JEV	NNP
cord-254895-ym0jsir5	311	50	)	)	-RRB-
cord-254895-ym0jsir5	311	51	and	and	CC
cord-254895-ym0jsir5	311	52	Influenza	Influenza	NNP
cord-254895-ym0jsir5	311	53	virus	virus	NN
cord-254895-ym0jsir5	311	54	in	in	IN
cord-254895-ym0jsir5	311	55	various	various	JJ
cord-254895-ym0jsir5	311	56	cell	cell	NN
cord-254895-ym0jsir5	311	57	types	type	NNS
cord-254895-ym0jsir5	311	58	with	with	IN
cord-254895-ym0jsir5	311	59	the	the	DT
cord-254895-ym0jsir5	311	60	exception	exception	NN
cord-254895-ym0jsir5	311	61	of	of	IN
cord-254895-ym0jsir5	311	62	pDCs	pDCs	NNP
cord-254895-ym0jsir5	311	63	.	.	.
cord-254895-ym0jsir5	312	1	The	the	DT
cord-254895-ym0jsir5	312	2	experiments	experiment	NNS
cord-254895-ym0jsir5	312	3	demonstrated	demonstrate	VBD
cord-254895-ym0jsir5	312	4	that	that	DT
cord-254895-ym0jsir5	312	5	type	type	NN
cord-254895-ym0jsir5	313	1	I	-PRON-	PRP
cord-254895-ym0jsir5	313	2	IFN	IFN	NNP
cord-254895-ym0jsir5	313	3	production	production	NN
cord-254895-ym0jsir5	313	4	by	by	IN
cord-254895-ym0jsir5	313	5	RIG	rig	NN
cord-254895-ym0jsir5	313	6	-	-	:
cord-254895-ym0jsir5	313	7	I	-PRON-	PRP
cord-254895-ym0jsir5	313	8	deficient	deficient	JJ
cord-254895-ym0jsir5	313	9	fibroblasts	fibroblast	NNS
cord-254895-ym0jsir5	313	10	and	and	CC
cord-254895-ym0jsir5	313	11	conventional	conventional	JJ
cord-254895-ym0jsir5	313	12	DCs	dc	NNS
cord-254895-ym0jsir5	313	13	is	be	VBZ
cord-254895-ym0jsir5	313	14	severely	severely	RB
cord-254895-ym0jsir5	313	15	impaired	impaired	JJ
cord-254895-ym0jsir5	313	16	in	in	IN
cord-254895-ym0jsir5	313	17	response	response	NN
cord-254895-ym0jsir5	313	18	to	to	IN
cord-254895-ym0jsir5	313	19	these	these	DT
cord-254895-ym0jsir5	313	20	RNA	RNA	NNP
cord-254895-ym0jsir5	313	21	viruses	virus	NNS
cord-254895-ym0jsir5	313	22	.	.	.
cord-254895-ym0jsir5	314	1	In	in	IN
cord-254895-ym0jsir5	314	2	contrast	contrast	NN
cord-254895-ym0jsir5	314	3	,	,	,
cord-254895-ym0jsir5	314	4	pDCs	pDCs	NNP
cord-254895-ym0jsir5	314	5	lacking	lack	VBG
cord-254895-ym0jsir5	314	6	RIG	rig	NN
cord-254895-ym0jsir5	314	7	-	-	:
cord-254895-ym0jsir5	314	8	I	-PRON-	PRP
cord-254895-ym0jsir5	314	9	show	show	VBP
cord-254895-ym0jsir5	314	10	normal	normal	JJ
cord-254895-ym0jsir5	314	11	type	type	NN
cord-254895-ym0jsir5	315	1	I	-PRON-	PRP
cord-254895-ym0jsir5	315	2	IFN	IFN	NNP
cord-254895-ym0jsir5	315	3	responses	response	NNS
cord-254895-ym0jsir5	315	4	to	to	IN
cord-254895-ym0jsir5	315	5	NDV	NDV	NNP
cord-254895-ym0jsir5	315	6	or	or	CC
cord-254895-ym0jsir5	315	7	VSV	VSV	NNP
cord-254895-ym0jsir5	315	8	for	for	IN
cord-254895-ym0jsir5	315	9	example	example	NN
cord-254895-ym0jsir5	315	10	,	,	,
cord-254895-ym0jsir5	315	11	as	as	IN
cord-254895-ym0jsir5	315	12	the	the	DT
cord-254895-ym0jsir5	315	13	pDC	pDC	NNP
cord-254895-ym0jsir5	315	14	response	response	NN
cord-254895-ym0jsir5	315	15	to	to	IN
cord-254895-ym0jsir5	315	16	these	these	DT
cord-254895-ym0jsir5	315	17	viruses	virus	NNS
cord-254895-ym0jsir5	315	18	is	be	VBZ
cord-254895-ym0jsir5	315	19	mediated	mediate	VBN
cord-254895-ym0jsir5	315	20	by	by	IN
cord-254895-ym0jsir5	315	21	TLR7	TLR7	NNP
cord-254895-ym0jsir5	315	22	.	.	.
cord-254895-ym0jsir5	316	1	The	the	DT
cord-254895-ym0jsir5	316	2	studies	study	NNS
cord-254895-ym0jsir5	316	3	performed	perform	VBD
cord-254895-ym0jsir5	316	4	so	so	RB
cord-254895-ym0jsir5	316	5	far	far	RB
cord-254895-ym0jsir5	316	6	indicate	indicate	VBP
cord-254895-ym0jsir5	316	7	that	that	IN
cord-254895-ym0jsir5	316	8	the	the	DT
cord-254895-ym0jsir5	316	9	RNA	RNA	NNP
cord-254895-ym0jsir5	316	10	helicases	helicase	NNS
cord-254895-ym0jsir5	316	11	RIG	rig	NN
cord-254895-ym0jsir5	316	12	-	-	:
cord-254895-ym0jsir5	316	13	I	I	NNP
cord-254895-ym0jsir5	316	14	and	and	CC
cord-254895-ym0jsir5	316	15	MDA5	MDA5	NNP
cord-254895-ym0jsir5	316	16	as	as	RB
cord-254895-ym0jsir5	316	17	well	well	RB
cord-254895-ym0jsir5	316	18	as	as	IN
cord-254895-ym0jsir5	316	19	their	-PRON-	PRP$
cord-254895-ym0jsir5	316	20	common	common	JJ
cord-254895-ym0jsir5	316	21	signaling	signaling	NN
cord-254895-ym0jsir5	316	22	adaptor	adaptor	NN
cord-254895-ym0jsir5	316	23	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	316	24	are	be	VBP
cord-254895-ym0jsir5	316	25	dispensible	dispensible	JJ
cord-254895-ym0jsir5	316	26	for	for	IN
cord-254895-ym0jsir5	316	27	viral	viral	JJ
cord-254895-ym0jsir5	316	28	triggering	triggering	NN
cord-254895-ym0jsir5	316	29	of	of	IN
cord-254895-ym0jsir5	316	30	type	type	NN
cord-254895-ym0jsir5	316	31	I	-PRON-	PRP
cord-254895-ym0jsir5	316	32	IFN	IFN	NNP
cord-254895-ym0jsir5	316	33	responses	response	NNS
cord-254895-ym0jsir5	316	34	in	in	IN
cord-254895-ym0jsir5	316	35	pDCs	pDCs	NNP
cord-254895-ym0jsir5	316	36	.	.	.
cord-254895-ym0jsir5	317	1	MDA5	MDA5	NNP
cord-254895-ym0jsir5	317	2	is	be	VBZ
cord-254895-ym0jsir5	317	3	another	another	DT
cord-254895-ym0jsir5	317	4	DExD	dexd	JJ
cord-254895-ym0jsir5	317	5	/	/	SYM
cord-254895-ym0jsir5	317	6	H	h	NN
cord-254895-ym0jsir5	317	7	-	-	HYPH
cord-254895-ym0jsir5	317	8	box	box	NN
cord-254895-ym0jsir5	317	9	-	-	HYPH
cord-254895-ym0jsir5	317	10	containing	contain	VBG
cord-254895-ym0jsir5	317	11	RNA	RNA	NNP
cord-254895-ym0jsir5	317	12	helicase	helicase	NN
cord-254895-ym0jsir5	317	13	that	that	WDT
cord-254895-ym0jsir5	317	14	is	be	VBZ
cord-254895-ym0jsir5	317	15	involved	involve	VBN
cord-254895-ym0jsir5	317	16	in	in	IN
cord-254895-ym0jsir5	317	17	the	the	DT
cord-254895-ym0jsir5	317	18	sensing	sensing	NN
cord-254895-ym0jsir5	317	19	of	of	IN
cord-254895-ym0jsir5	317	20	intracellular	intracellular	JJ
cord-254895-ym0jsir5	317	21	dsRNA	dsRNA	NNS
cord-254895-ym0jsir5	317	22	and	and	CC
cord-254895-ym0jsir5	317	23	the	the	DT
cord-254895-ym0jsir5	317	24	induction	induction	NN
cord-254895-ym0jsir5	317	25	of	of	IN
cord-254895-ym0jsir5	317	26	type	type	NN
cord-254895-ym0jsir5	318	1	I	-PRON-	PRP
cord-254895-ym0jsir5	318	2	IFN	IFN	NNP
cord-254895-ym0jsir5	318	3	in	in	IN
cord-254895-ym0jsir5	318	4	response	response	NN
cord-254895-ym0jsir5	318	5	to	to	IN
cord-254895-ym0jsir5	318	6	RNA	RNA	NNP
cord-254895-ym0jsir5	318	7	viruses	virus	NNS
cord-254895-ym0jsir5	318	8	(	(	-LRB-
cord-254895-ym0jsir5	318	9	Andrejeva	Andrejeva	NNP
cord-254895-ym0jsir5	318	10	et	et	NNP
cord-254895-ym0jsir5	318	11	al	al	NNP
cord-254895-ym0jsir5	318	12	.	.	NNP
cord-254895-ym0jsir5	318	13	,	,	,
cord-254895-ym0jsir5	318	14	2004	2004	CD
cord-254895-ym0jsir5	318	15	)	)	-RRB-
cord-254895-ym0jsir5	318	16	.	.	.
cord-254895-ym0jsir5	319	1	It	-PRON-	PRP
cord-254895-ym0jsir5	319	2	is	be	VBZ
cord-254895-ym0jsir5	319	3	the	the	DT
cord-254895-ym0jsir5	319	4	closest	close	JJS
cord-254895-ym0jsir5	319	5	relative	relative	NN
cord-254895-ym0jsir5	319	6	of	of	IN
cord-254895-ym0jsir5	319	7	RIG	rig	NN
cord-254895-ym0jsir5	319	8	-	-	:
cord-254895-ym0jsir5	319	9	I	I	NNP
cord-254895-ym0jsir5	319	10	,	,	,
cord-254895-ym0jsir5	319	11	exhibiting	exhibit	VBG
cord-254895-ym0jsir5	319	12	23	23	CD
cord-254895-ym0jsir5	319	13	and	and	CC
cord-254895-ym0jsir5	319	14	35	35	CD
cord-254895-ym0jsir5	319	15	%	%	NN
cord-254895-ym0jsir5	319	16	amino	amino	NN
cord-254895-ym0jsir5	319	17	acid	acid	NN
cord-254895-ym0jsir5	319	18	homology	homology	NN
cord-254895-ym0jsir5	319	19	in	in	IN
cord-254895-ym0jsir5	319	20	the	the	DT
cord-254895-ym0jsir5	319	21	N	n	CD
cord-254895-ym0jsir5	319	22	-	-	HYPH
cord-254895-ym0jsir5	319	23	terminal	terminal	NN
cord-254895-ym0jsir5	319	24	CARD	card	NN
cord-254895-ym0jsir5	319	25	and	and	CC
cord-254895-ym0jsir5	319	26	C	C	NNP
cord-254895-ym0jsir5	319	27	-	-	HYPH
cord-254895-ym0jsir5	319	28	terminal	terminal	NN
cord-254895-ym0jsir5	319	29	helicase	helicase	NN
cord-254895-ym0jsir5	319	30	domain	domain	NN
cord-254895-ym0jsir5	319	31	,	,	,
cord-254895-ym0jsir5	319	32	respectively	respectively	RB
cord-254895-ym0jsir5	319	33	.	.	.
cord-254895-ym0jsir5	320	1	It	-PRON-	PRP
cord-254895-ym0jsir5	320	2	was	be	VBD
cord-254895-ym0jsir5	320	3	reported	report	VBN
cord-254895-ym0jsir5	320	4	in	in	IN
cord-254895-ym0jsir5	320	5	a	a	DT
cord-254895-ym0jsir5	320	6	previous	previous	JJ
cord-254895-ym0jsir5	320	7	publication	publication	NN
cord-254895-ym0jsir5	320	8	,	,	,
cord-254895-ym0jsir5	320	9	that	that	IN
cord-254895-ym0jsir5	320	10	MDA5	MDA5	NNP
cord-254895-ym0jsir5	320	11	,	,	,
cord-254895-ym0jsir5	320	12	which	which	WDT
cord-254895-ym0jsir5	320	13	was	be	VBD
cord-254895-ym0jsir5	320	14	then	then	RB
cord-254895-ym0jsir5	320	15	called	call	VBN
cord-254895-ym0jsir5	320	16	Helicard	Helicard	NNP
cord-254895-ym0jsir5	320	17	,	,	,
cord-254895-ym0jsir5	320	18	is	be	VBZ
cord-254895-ym0jsir5	320	19	cleaved	cleave	VBN
cord-254895-ym0jsir5	320	20	by	by	IN
cord-254895-ym0jsir5	320	21	caspases	caspase	NNS
cord-254895-ym0jsir5	320	22	upon	upon	IN
cord-254895-ym0jsir5	320	23	induction	induction	NN
cord-254895-ym0jsir5	320	24	of	of	IN
cord-254895-ym0jsir5	320	25	apoptosis	apoptosis	NN
cord-254895-ym0jsir5	320	26	,	,	,
cord-254895-ym0jsir5	320	27	thereby	thereby	RB
cord-254895-ym0jsir5	320	28	separating	separate	VBG
cord-254895-ym0jsir5	320	29	the	the	DT
cord-254895-ym0jsir5	320	30	CARD	card	NN
cord-254895-ym0jsir5	320	31	domains	domain	NNS
cord-254895-ym0jsir5	320	32	from	from	IN
cord-254895-ym0jsir5	320	33	the	the	DT
cord-254895-ym0jsir5	320	34	C	C	NNP
cord-254895-ym0jsir5	320	35	-	-	HYPH
cord-254895-ym0jsir5	320	36	terminal	terminal	NN
cord-254895-ym0jsir5	320	37	helicase	helicase	NN
cord-254895-ym0jsir5	320	38	domain	domain	NN
cord-254895-ym0jsir5	320	39	,	,	,
cord-254895-ym0jsir5	320	40	which	which	WDT
cord-254895-ym0jsir5	320	41	localizes	localize	VBZ
cord-254895-ym0jsir5	320	42	to	to	IN
cord-254895-ym0jsir5	320	43	the	the	DT
cord-254895-ym0jsir5	320	44	nucleus	nucleus	NN
cord-254895-ym0jsir5	320	45	where	where	WRB
cord-254895-ym0jsir5	320	46	it	-PRON-	PRP
cord-254895-ym0jsir5	320	47	is	be	VBZ
cord-254895-ym0jsir5	320	48	involved	involve	VBN
cord-254895-ym0jsir5	320	49	in	in	IN
cord-254895-ym0jsir5	320	50	DNA	dna	NN
cord-254895-ym0jsir5	320	51	degradation	degradation	NN
cord-254895-ym0jsir5	320	52	and	and	CC
cord-254895-ym0jsir5	320	53	nuclear	nuclear	JJ
cord-254895-ym0jsir5	320	54	remodelling	remodelling	NN
cord-254895-ym0jsir5	320	55	during	during	IN
cord-254895-ym0jsir5	320	56	apoptotic	apoptotic	JJ
cord-254895-ym0jsir5	320	57	cell	cell	NN
cord-254895-ym0jsir5	320	58	death	death	NN
cord-254895-ym0jsir5	320	59	(	(	-LRB-
cord-254895-ym0jsir5	320	60	Kovacsovics	Kovacsovics	NNP
cord-254895-ym0jsir5	320	61	et	et	NNP
cord-254895-ym0jsir5	320	62	al	al	NNP
cord-254895-ym0jsir5	320	63	.	.	NNP
cord-254895-ym0jsir5	320	64	,	,	,
cord-254895-ym0jsir5	320	65	2002	2002	CD
cord-254895-ym0jsir5	320	66	)	)	-RRB-
cord-254895-ym0jsir5	320	67	.	.	.
cord-254895-ym0jsir5	321	1	Furthermore	furthermore	RB
cord-254895-ym0jsir5	321	2	,	,	,
cord-254895-ym0jsir5	321	3	MDA5	MDA5	NNP
cord-254895-ym0jsir5	321	4	has	have	VBZ
cord-254895-ym0jsir5	321	5	been	be	VBN
cord-254895-ym0jsir5	321	6	implicated	implicate	VBN
cord-254895-ym0jsir5	321	7	in	in	IN
cord-254895-ym0jsir5	321	8	the	the	DT
cord-254895-ym0jsir5	321	9	regulation	regulation	NN
cord-254895-ym0jsir5	321	10	of	of	IN
cord-254895-ym0jsir5	321	11	the	the	DT
cord-254895-ym0jsir5	321	12	growth	growth	NN
cord-254895-ym0jsir5	321	13	and	and	CC
cord-254895-ym0jsir5	321	14	differentiation	differentiation	NN
cord-254895-ym0jsir5	321	15	of	of	IN
cord-254895-ym0jsir5	321	16	melanoma	melanoma	NN
cord-254895-ym0jsir5	321	17	cells	cell	NNS
cord-254895-ym0jsir5	322	1	(	(	-LRB-
cord-254895-ym0jsir5	322	2	Kang	Kang	NNP
cord-254895-ym0jsir5	322	3	et	et	NNP
cord-254895-ym0jsir5	322	4	al	al	NNP
cord-254895-ym0jsir5	322	5	.	.	NNP
cord-254895-ym0jsir5	322	6	,	,	,
cord-254895-ym0jsir5	322	7	2002	2002	CD
cord-254895-ym0jsir5	322	8	)	)	-RRB-
cord-254895-ym0jsir5	322	9	.	.	.
cord-254895-ym0jsir5	323	1	MDA5	MDA5	NNP
cord-254895-ym0jsir5	323	2	is	be	VBZ
cord-254895-ym0jsir5	323	3	ubiquitously	ubiquitously	RB
cord-254895-ym0jsir5	323	4	expressed	express	VBN
cord-254895-ym0jsir5	323	5	in	in	IN
cord-254895-ym0jsir5	323	6	low	low	JJ
cord-254895-ym0jsir5	323	7	abundance	abundance	NN
cord-254895-ym0jsir5	323	8	and	and	CC
cord-254895-ym0jsir5	323	9	similarly	similarly	RB
cord-254895-ym0jsir5	323	10	to	to	TO
cord-254895-ym0jsir5	323	11	RIG	rig	VB
cord-254895-ym0jsir5	323	12	-	-	:
cord-254895-ym0jsir5	323	13	I	I	NNP
cord-254895-ym0jsir5	323	14	and	and	CC
cord-254895-ym0jsir5	323	15	LGP2	LGP2	NNP
cord-254895-ym0jsir5	324	1	its	-PRON-	PRP$
cord-254895-ym0jsir5	324	2	expression	expression	NN
cord-254895-ym0jsir5	324	3	is	be	VBZ
cord-254895-ym0jsir5	324	4	induced	induce	VBN
cord-254895-ym0jsir5	324	5	by	by	IN
cord-254895-ym0jsir5	324	6	type	type	NN
cord-254895-ym0jsir5	324	7	I	-PRON-	PRP
cord-254895-ym0jsir5	324	8	IFN	IFN	NNP
cord-254895-ym0jsir5	324	9	.	.	.
cord-254895-ym0jsir5	325	1	Like	like	IN
cord-254895-ym0jsir5	325	2	RIG	rig	NN
cord-254895-ym0jsir5	325	3	-	-	:
cord-254895-ym0jsir5	325	4	I	I	NNP
cord-254895-ym0jsir5	325	5	,	,	,
cord-254895-ym0jsir5	325	6	MDA5	MDA5	NNP
cord-254895-ym0jsir5	325	7	interacts	interact	VBZ
cord-254895-ym0jsir5	325	8	with	with	IN
cord-254895-ym0jsir5	325	9	the	the	DT
cord-254895-ym0jsir5	325	10	adapter	adapter	NN
cord-254895-ym0jsir5	325	11	protein	protein	NN
cord-254895-ym0jsir5	325	12	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	325	13	upon	upon	IN
cord-254895-ym0jsir5	325	14	ligand	ligand	NN
cord-254895-ym0jsir5	325	15	binding	binding	NN
cord-254895-ym0jsir5	325	16	leading	lead	VBG
cord-254895-ym0jsir5	325	17	to	to	IN
cord-254895-ym0jsir5	325	18	activation	activation	NN
cord-254895-ym0jsir5	325	19	of	of	IN
cord-254895-ym0jsir5	325	20	protein	protein	NN
cord-254895-ym0jsir5	325	21	kinases	kinase	NNS
cord-254895-ym0jsir5	325	22	that	that	WDT
cord-254895-ym0jsir5	325	23	subsequently	subsequently	RB
cord-254895-ym0jsir5	325	24	activate	activate	VBP
cord-254895-ym0jsir5	325	25	transcription	transcription	NN
cord-254895-ym0jsir5	325	26	factors	factor	NNS
cord-254895-ym0jsir5	325	27	IRF3	IRF3	NNP
cord-254895-ym0jsir5	325	28	,	,	,
cord-254895-ym0jsir5	325	29	IRF7	IRF7	NNP
cord-254895-ym0jsir5	325	30	and	and	CC
cord-254895-ym0jsir5	325	31	NFkB	NFkB	NNP
cord-254895-ym0jsir5	325	32	,	,	,
cord-254895-ym0jsir5	325	33	respectively	respectively	RB
cord-254895-ym0jsir5	325	34	.	.	.
cord-254895-ym0jsir5	326	1	It	-PRON-	PRP
cord-254895-ym0jsir5	326	2	was	be	VBD
cord-254895-ym0jsir5	326	3	found	find	VBN
cord-254895-ym0jsir5	326	4	recently	recently	RB
cord-254895-ym0jsir5	326	5	by	by	IN
cord-254895-ym0jsir5	326	6	Sato	Sato	NNP
cord-254895-ym0jsir5	326	7	et	et	FW
cord-254895-ym0jsir5	326	8	al	al	NNP
cord-254895-ym0jsir5	326	9	.	.	.
cord-254895-ym0jsir5	327	1	(	(	-LRB-
cord-254895-ym0jsir5	327	2	2007	2007	CD
cord-254895-ym0jsir5	327	3	)	)	-RRB-
cord-254895-ym0jsir5	327	4	that	that	IN
cord-254895-ym0jsir5	327	5	in	in	IN
cord-254895-ym0jsir5	327	6	contrast	contrast	NN
cord-254895-ym0jsir5	327	7	to	to	IN
cord-254895-ym0jsir5	327	8	RIG	rig	NN
cord-254895-ym0jsir5	327	9	-	-	:
cord-254895-ym0jsir5	327	10	I	I	NNP
cord-254895-ym0jsir5	327	11	,	,	,
cord-254895-ym0jsir5	327	12	the	the	DT
cord-254895-ym0jsir5	327	13	C	c	NN
cord-254895-ym0jsir5	327	14	-	-	HYPH
cord-254895-ym0jsir5	327	15	terminal	terminal	NN
cord-254895-ym0jsir5	327	16	regulatory	regulatory	JJ
cord-254895-ym0jsir5	327	17	domain	domain	NN
cord-254895-ym0jsir5	327	18	of	of	IN
cord-254895-ym0jsir5	327	19	MDA5	MDA5	NNP
cord-254895-ym0jsir5	327	20	did	do	VBD
cord-254895-ym0jsir5	327	21	not	not	RB
cord-254895-ym0jsir5	327	22	exert	exert	VB
cord-254895-ym0jsir5	327	23	a	a	DT
cord-254895-ym0jsir5	327	24	repressor	repressor	NN
cord-254895-ym0jsir5	327	25	function	function	NN
cord-254895-ym0jsir5	327	26	on	on	IN
cord-254895-ym0jsir5	327	27	MDA5	MDA5	NNP
cord-254895-ym0jsir5	327	28	signaling	signaling	NN
cord-254895-ym0jsir5	327	29	,	,	,
cord-254895-ym0jsir5	327	30	which	which	WDT
cord-254895-ym0jsir5	327	31	was	be	VBD
cord-254895-ym0jsir5	327	32	also	also	RB
cord-254895-ym0jsir5	327	33	not	not	RB
cord-254895-ym0jsir5	327	34	inhibited	inhibit	VBN
cord-254895-ym0jsir5	327	35	by	by	IN
cord-254895-ym0jsir5	327	36	LGP2	LGP2	NNP
cord-254895-ym0jsir5	327	37	.	.	.
cord-254895-ym0jsir5	328	1	MDA5	mda5	JJ
cord-254895-ym0jsir5	328	2	overexpression	overexpression	NN
cord-254895-ym0jsir5	328	3	in	in	IN
cord-254895-ym0jsir5	328	4	cell	cell	NN
cord-254895-ym0jsir5	328	5	lines	line	NNS
cord-254895-ym0jsir5	328	6	even	even	RB
cord-254895-ym0jsir5	328	7	at	at	IN
cord-254895-ym0jsir5	328	8	low	low	JJ
cord-254895-ym0jsir5	328	9	levels	level	NNS
cord-254895-ym0jsir5	328	10	induces	induce	VBZ
cord-254895-ym0jsir5	328	11	IFN	IFN	NNP
cord-254895-ym0jsir5	328	12	-	-	HYPH
cord-254895-ym0jsir5	328	13	b	b	NN
cord-254895-ym0jsir5	328	14	promoter	promoter	NN
cord-254895-ym0jsir5	328	15	activity	activity	NN
cord-254895-ym0jsir5	328	16	in	in	IN
cord-254895-ym0jsir5	328	17	the	the	DT
cord-254895-ym0jsir5	328	18	absence	absence	NN
cord-254895-ym0jsir5	328	19	of	of	IN
cord-254895-ym0jsir5	328	20	ligand	ligand	NN
cord-254895-ym0jsir5	328	21	binding	binding	NN
cord-254895-ym0jsir5	328	22	.	.	.
cord-254895-ym0jsir5	329	1	Thus	thus	RB
cord-254895-ym0jsir5	329	2	,	,	,
cord-254895-ym0jsir5	329	3	MDA5	mda5	JJ
cord-254895-ym0jsir5	329	4	expression	expression	NN
cord-254895-ym0jsir5	329	5	which	which	WDT
cord-254895-ym0jsir5	329	6	is	be	VBZ
cord-254895-ym0jsir5	329	7	upregulated	upregulate	VBN
cord-254895-ym0jsir5	329	8	in	in	IN
cord-254895-ym0jsir5	329	9	response	response	NN
cord-254895-ym0jsir5	329	10	to	to	TO
cord-254895-ym0jsir5	329	11	type	type	VB
cord-254895-ym0jsir5	329	12	I	-PRON-	PRP
cord-254895-ym0jsir5	329	13	IFN	IFN	NNP
cord-254895-ym0jsir5	329	14	signaling	signal	VBG
cord-254895-ym0jsir5	329	15	may	may	MD
cord-254895-ym0jsir5	329	16	function	function	VB
cord-254895-ym0jsir5	329	17	as	as	IN
cord-254895-ym0jsir5	329	18	an	an	DT
cord-254895-ym0jsir5	329	19	amplifier	amplifier	NN
cord-254895-ym0jsir5	329	20	of	of	IN
cord-254895-ym0jsir5	329	21	type	type	NN
cord-254895-ym0jsir5	330	1	I	-PRON-	PRP
cord-254895-ym0jsir5	330	2	IFN	IFN	NNP
cord-254895-ym0jsir5	330	3	production	production	NN
cord-254895-ym0jsir5	330	4	even	even	RB
cord-254895-ym0jsir5	330	5	in	in	IN
cord-254895-ym0jsir5	330	6	the	the	DT
cord-254895-ym0jsir5	330	7	absence	absence	NN
cord-254895-ym0jsir5	330	8	of	of	IN
cord-254895-ym0jsir5	330	9	specific	specific	JJ
cord-254895-ym0jsir5	330	10	MDA5	mda5	JJ
cord-254895-ym0jsir5	330	11	ligands	ligand	NNS
cord-254895-ym0jsir5	330	12	.	.	.
cord-254895-ym0jsir5	331	1	Although	although	IN
cord-254895-ym0jsir5	331	2	RIG	rig	NN
cord-254895-ym0jsir5	331	3	-	-	:
cord-254895-ym0jsir5	331	4	I	I	NNP
cord-254895-ym0jsir5	331	5	and	and	CC
cord-254895-ym0jsir5	331	6	MDA5	MDA5	NNP
cord-254895-ym0jsir5	331	7	are	be	VBP
cord-254895-ym0jsir5	331	8	similar	similar	JJ
cord-254895-ym0jsir5	331	9	proteins	protein	NNS
cord-254895-ym0jsir5	331	10	inducing	induce	VBG
cord-254895-ym0jsir5	331	11	synthesis	synthesis	NN
cord-254895-ym0jsir5	331	12	of	of	IN
cord-254895-ym0jsir5	331	13	type	type	NN
cord-254895-ym0jsir5	332	1	I	-PRON-	PRP
cord-254895-ym0jsir5	332	2	IFN	IFN	NNP
cord-254895-ym0jsir5	333	1	via	via	IN
cord-254895-ym0jsir5	333	2	the	the	DT
cord-254895-ym0jsir5	333	3	same	same	JJ
cord-254895-ym0jsir5	333	4	signaling	signal	VBG
cord-254895-ym0jsir5	333	5	pathway	pathway	NN
cord-254895-ym0jsir5	333	6	,	,	,
cord-254895-ym0jsir5	333	7	they	-PRON-	PRP
cord-254895-ym0jsir5	333	8	are	be	VBP
cord-254895-ym0jsir5	333	9	specialized	specialize	VBN
cord-254895-ym0jsir5	333	10	in	in	IN
cord-254895-ym0jsir5	333	11	the	the	DT
cord-254895-ym0jsir5	333	12	recognition	recognition	NN
cord-254895-ym0jsir5	333	13	of	of	IN
cord-254895-ym0jsir5	333	14	different	different	JJ
cord-254895-ym0jsir5	333	15	viruses	virus	NNS
cord-254895-ym0jsir5	333	16	.	.	.
cord-254895-ym0jsir5	334	1	In	in	IN
cord-254895-ym0jsir5	334	2	vitro	vitro	FW
cord-254895-ym0jsir5	334	3	studies	study	NNS
cord-254895-ym0jsir5	334	4	performed	perform	VBN
cord-254895-ym0jsir5	334	5	with	with	IN
cord-254895-ym0jsir5	334	6	embryonic	embryonic	JJ
cord-254895-ym0jsir5	334	7	fibroblasts	fibroblast	NNS
cord-254895-ym0jsir5	334	8	and	and	CC
cord-254895-ym0jsir5	334	9	conventional	conventional	JJ
cord-254895-ym0jsir5	334	10	DCs	dc	NNS
cord-254895-ym0jsir5	334	11	derived	derive	VBN
cord-254895-ym0jsir5	334	12	from	from	IN
cord-254895-ym0jsir5	334	13	MDA5	mda5	JJ
cord-254895-ym0jsir5	334	14	knockout	knockout	NN
cord-254895-ym0jsir5	334	15	mice	mouse	NNS
cord-254895-ym0jsir5	334	16	have	have	VBP
cord-254895-ym0jsir5	334	17	shown	show	VBN
cord-254895-ym0jsir5	334	18	that	that	IN
cord-254895-ym0jsir5	334	19	MDA5	MDA5	NNP
cord-254895-ym0jsir5	334	20	is	be	VBZ
cord-254895-ym0jsir5	334	21	specifically	specifically	RB
cord-254895-ym0jsir5	334	22	required	require	VBN
cord-254895-ym0jsir5	334	23	for	for	IN
cord-254895-ym0jsir5	334	24	the	the	DT
cord-254895-ym0jsir5	334	25	recognition	recognition	NN
cord-254895-ym0jsir5	334	26	of	of	IN
cord-254895-ym0jsir5	334	27	intracellular	intracellular	JJ
cord-254895-ym0jsir5	334	28	poly	poly	NN
cord-254895-ym0jsir5	334	29	(	(	-LRB-
cord-254895-ym0jsir5	334	30	I	i	NN
cord-254895-ym0jsir5	334	31	:	:	:
cord-254895-ym0jsir5	334	32	C	C	NNP
cord-254895-ym0jsir5	334	33	)	)	-RRB-
cord-254895-ym0jsir5	334	34	dsRNA	dsRNA	.
cord-254895-ym0jsir5	335	1	(	(	-LRB-
cord-254895-ym0jsir5	335	2	but	but	CC
cord-254895-ym0jsir5	335	3	not	not	RB
cord-254895-ym0jsir5	335	4	in	in	IN
cord-254895-ym0jsir5	335	5	vitro	vitro	FW
cord-254895-ym0jsir5	335	6	transcribed	transcribe	VBN
cord-254895-ym0jsir5	335	7	PPP	PPP	NNP
cord-254895-ym0jsir5	335	8	-	-	HYPH
cord-254895-ym0jsir5	335	9	RNA	RNA	NNP
cord-254895-ym0jsir5	335	10	)	)	-RRB-
cord-254895-ym0jsir5	335	11	and	and	CC
cord-254895-ym0jsir5	335	12	picornaviruses	picornavirus	NNS
cord-254895-ym0jsir5	335	13	such	such	JJ
cord-254895-ym0jsir5	335	14	as	as	IN
cord-254895-ym0jsir5	335	15	encephalomyocarditis	encephalomyocarditis	NNP
cord-254895-ym0jsir5	335	16	virus	virus	NN
cord-254895-ym0jsir5	335	17	(	(	-LRB-
cord-254895-ym0jsir5	335	18	EMCV	EMCV	NNP
cord-254895-ym0jsir5	335	19	)	)	-RRB-
cord-254895-ym0jsir5	335	20	,	,	,
cord-254895-ym0jsir5	335	21	Theiler	Theiler	NNP
cord-254895-ym0jsir5	335	22	's	's	POS
cord-254895-ym0jsir5	335	23	virus	virus	NN
cord-254895-ym0jsir5	335	24	and	and	CC
cord-254895-ym0jsir5	335	25	Mengo	Mengo	NNP
cord-254895-ym0jsir5	335	26	virus	virus	NN
cord-254895-ym0jsir5	335	27	,	,	,
cord-254895-ym0jsir5	335	28	whereas	whereas	IN
cord-254895-ym0jsir5	335	29	RIG	rig	NN
cord-254895-ym0jsir5	335	30	-	-	:
cord-254895-ym0jsir5	335	31	I	-PRON-	PRP
cord-254895-ym0jsir5	335	32	was	be	VBD
cord-254895-ym0jsir5	335	33	not	not	RB
cord-254895-ym0jsir5	335	34	necessary	necessary	JJ
cord-254895-ym0jsir5	335	35	for	for	IN
cord-254895-ym0jsir5	335	36	the	the	DT
cord-254895-ym0jsir5	335	37	response	response	NN
cord-254895-ym0jsir5	335	38	to	to	IN
cord-254895-ym0jsir5	335	39	poly	poly	NNP
cord-254895-ym0jsir5	335	40	(	(	-LRB-
cord-254895-ym0jsir5	335	41	I	i	NN
cord-254895-ym0jsir5	335	42	:	:	:
cord-254895-ym0jsir5	335	43	C	C	NNP
cord-254895-ym0jsir5	335	44	)	)	-RRB-
cord-254895-ym0jsir5	335	45	or	or	CC
cord-254895-ym0jsir5	335	46	picornaviruses	picornaviruse	VBZ
cord-254895-ym0jsir5	335	47	Gitlin	Gitlin	NNP
cord-254895-ym0jsir5	335	48	et	et	NNP
cord-254895-ym0jsir5	335	49	al	al	NNP
cord-254895-ym0jsir5	335	50	.	.	NNP
cord-254895-ym0jsir5	335	51	,	,	,
cord-254895-ym0jsir5	335	52	2006	2006	CD
cord-254895-ym0jsir5	335	53	)	)	-RRB-
cord-254895-ym0jsir5	335	54	.	.	.
cord-254895-ym0jsir5	336	1	In	in	IN
cord-254895-ym0jsir5	336	2	addition	addition	NN
cord-254895-ym0jsir5	336	3	,	,	,
cord-254895-ym0jsir5	336	4	it	-PRON-	PRP
cord-254895-ym0jsir5	336	5	was	be	VBD
cord-254895-ym0jsir5	336	6	shown	show	VBN
cord-254895-ym0jsir5	336	7	that	that	IN
cord-254895-ym0jsir5	336	8	MDA5	MDA5	NNP
cord-254895-ym0jsir5	336	9	might	may	MD
cord-254895-ym0jsir5	336	10	also	also	RB
cord-254895-ym0jsir5	336	11	play	play	VB
cord-254895-ym0jsir5	336	12	a	a	DT
cord-254895-ym0jsir5	336	13	role	role	NN
cord-254895-ym0jsir5	336	14	in	in	IN
cord-254895-ym0jsir5	336	15	the	the	DT
cord-254895-ym0jsir5	336	16	measles	measle	NNS
cord-254895-ym0jsir5	336	17	virus	virus	NN
cord-254895-ym0jsir5	336	18	(	(	-LRB-
cord-254895-ym0jsir5	336	19	MV	MV	NNP
cord-254895-ym0jsir5	336	20	)	)	-RRB-
cord-254895-ym0jsir5	336	21	induced	induce	VBN
cord-254895-ym0jsir5	336	22	activation	activation	NN
cord-254895-ym0jsir5	336	23	of	of	IN
cord-254895-ym0jsir5	336	24	IFN	IFN	NNP
cord-254895-ym0jsir5	336	25	-	-	HYPH
cord-254895-ym0jsir5	336	26	b	b	NNP
cord-254895-ym0jsir5	336	27	mRNA	mrna	NN
cord-254895-ym0jsir5	336	28	synthesis	synthesis	NN
cord-254895-ym0jsir5	336	29	since	since	IN
cord-254895-ym0jsir5	336	30	A549	a549	JJ
cord-254895-ym0jsir5	336	31	cells	cell	NNS
cord-254895-ym0jsir5	336	32	transfected	transfecte	VBN
cord-254895-ym0jsir5	336	33	with	with	IN
cord-254895-ym0jsir5	336	34	MDA5	MDA5	NNP
cord-254895-ym0jsir5	336	35	showed	show	VBD
cord-254895-ym0jsir5	336	36	a	a	DT
cord-254895-ym0jsir5	336	37	strong	strong	JJ
cord-254895-ym0jsir5	336	38	activation	activation	NN
cord-254895-ym0jsir5	336	39	of	of	IN
cord-254895-ym0jsir5	336	40	the	the	DT
cord-254895-ym0jsir5	336	41	IFN	IFN	NNP
cord-254895-ym0jsir5	336	42	-	-	HYPH
cord-254895-ym0jsir5	336	43	b	b	NN
cord-254895-ym0jsir5	336	44	promoter	promoter	NN
cord-254895-ym0jsir5	336	45	upon	upon	IN
cord-254895-ym0jsir5	336	46	infection	infection	NN
cord-254895-ym0jsir5	336	47	with	with	IN
cord-254895-ym0jsir5	336	48	MV	MV	NNP
cord-254895-ym0jsir5	336	49	.	.	.
cord-254895-ym0jsir5	337	1	In	in	IN
cord-254895-ym0jsir5	337	2	contrast	contrast	NN
cord-254895-ym0jsir5	337	3	,	,	,
cord-254895-ym0jsir5	337	4	the	the	DT
cord-254895-ym0jsir5	337	5	virus	virus	NN
cord-254895-ym0jsir5	337	6	did	do	VBD
cord-254895-ym0jsir5	337	7	not	not	RB
cord-254895-ym0jsir5	337	8	enhance	enhance	VB
cord-254895-ym0jsir5	337	9	reporter	reporter	NN
cord-254895-ym0jsir5	337	10	gene	gene	NN
cord-254895-ym0jsir5	337	11	activity	activity	NN
cord-254895-ym0jsir5	337	12	in	in	IN
cord-254895-ym0jsir5	337	13	cells	cell	NNS
cord-254895-ym0jsir5	337	14	that	that	WDT
cord-254895-ym0jsir5	337	15	overexpressed	overexpresse	VBD
cord-254895-ym0jsir5	337	16	RIG	rig	NN
cord-254895-ym0jsir5	337	17	-	-	:
cord-254895-ym0jsir5	337	18	I	i	NN
cord-254895-ym0jsir5	337	19	(	(	-LRB-
cord-254895-ym0jsir5	337	20	Berghall	Berghall	NNP
cord-254895-ym0jsir5	337	21	et	et	FW
cord-254895-ym0jsir5	337	22	al	al	NNP
cord-254895-ym0jsir5	337	23	.	.	NNP
cord-254895-ym0jsir5	337	24	,	,	,
cord-254895-ym0jsir5	337	25	2006	2006	CD
cord-254895-ym0jsir5	337	26	)	)	-RRB-
cord-254895-ym0jsir5	337	27	.	.	.
cord-254895-ym0jsir5	338	1	MDA5	MDA5	NNP
cord-254895-ym0jsir5	338	2	was	be	VBD
cord-254895-ym0jsir5	338	3	not	not	RB
cord-254895-ym0jsir5	338	4	required	require	VBN
cord-254895-ym0jsir5	338	5	for	for	IN
cord-254895-ym0jsir5	338	6	recognition	recognition	NN
cord-254895-ym0jsir5	338	7	of	of	IN
cord-254895-ym0jsir5	338	8	VSV	VSV	NNP
cord-254895-ym0jsir5	338	9	,	,	,
cord-254895-ym0jsir5	338	10	NDV	NDV	NNP
cord-254895-ym0jsir5	338	11	,	,	,
cord-254895-ym0jsir5	338	12	JEV	JEV	NNP
cord-254895-ym0jsir5	338	13	,	,	,
cord-254895-ym0jsir5	338	14	SeV	sev	NN
cord-254895-ym0jsir5	338	15	and	and	CC
cord-254895-ym0jsir5	338	16	influenza	influenza	NN
cord-254895-ym0jsir5	338	17	virus	virus	NN
cord-254895-ym0jsir5	338	18	,	,	,
cord-254895-ym0jsir5	338	19	indicating	indicate	VBG
cord-254895-ym0jsir5	338	20	that	that	DT
cord-254895-ym0jsir5	338	21	RIG	rig	NN
cord-254895-ym0jsir5	339	1	-I	-I	NNP
cord-254895-ym0jsir5	339	2	was	be	VBD
cord-254895-ym0jsir5	339	3	the	the	DT
cord-254895-ym0jsir5	339	4	predominant	predominant	JJ
cord-254895-ym0jsir5	339	5	pattern	pattern	NN
cord-254895-ym0jsir5	339	6	recognition	recognition	NN
cord-254895-ym0jsir5	339	7	receptor	receptor	NN
cord-254895-ym0jsir5	339	8	for	for	IN
cord-254895-ym0jsir5	339	9	these	these	DT
cord-254895-ym0jsir5	339	10	viruses	virus	NNS
cord-254895-ym0jsir5	339	11	.	.	.
cord-254895-ym0jsir5	340	1	It	-PRON-	PRP
cord-254895-ym0jsir5	340	2	is	be	VBZ
cord-254895-ym0jsir5	340	3	currently	currently	RB
cord-254895-ym0jsir5	340	4	unknown	unknown	JJ
cord-254895-ym0jsir5	340	5	which	which	WDT
cord-254895-ym0jsir5	340	6	specific	specific	JJ
cord-254895-ym0jsir5	340	7	viral	viral	JJ
cord-254895-ym0jsir5	340	8	RNA	RNA	NNP
cord-254895-ym0jsir5	340	9	motifs	motif	NNS
cord-254895-ym0jsir5	340	10	in	in	IN
cord-254895-ym0jsir5	340	11	picornaviruses	picornavirus	NNS
cord-254895-ym0jsir5	340	12	are	be	VBP
cord-254895-ym0jsir5	340	13	recognized	recognize	VBN
cord-254895-ym0jsir5	340	14	by	by	IN
cord-254895-ym0jsir5	340	15	MDA5	MDA5	NNP
cord-254895-ym0jsir5	340	16	and	and	CC
cord-254895-ym0jsir5	340	17	how	how	WRB
cord-254895-ym0jsir5	340	18	ligand	ligand	NN
cord-254895-ym0jsir5	340	19	specificity	specificity	NN
cord-254895-ym0jsir5	340	20	is	be	VBZ
cord-254895-ym0jsir5	340	21	determined	determine	VBN
cord-254895-ym0jsir5	340	22	on	on	IN
cord-254895-ym0jsir5	340	23	the	the	DT
cord-254895-ym0jsir5	340	24	molecular	molecular	JJ
cord-254895-ym0jsir5	340	25	level	level	NN
cord-254895-ym0jsir5	340	26	.	.	.
cord-254895-ym0jsir5	341	1	The	the	DT
cord-254895-ym0jsir5	341	2	in	in	IN
cord-254895-ym0jsir5	341	3	vivo	vivo	NN
cord-254895-ym0jsir5	341	4	relevance	relevance	NN
cord-254895-ym0jsir5	341	5	of	of	IN
cord-254895-ym0jsir5	341	6	the	the	DT
cord-254895-ym0jsir5	341	7	RIG	rig	NN
cord-254895-ym0jsir5	341	8	-	-	:
cord-254895-ym0jsir5	341	9	I	I	NNP
cord-254895-ym0jsir5	341	10	and	and	CC
cord-254895-ym0jsir5	341	11	MDA5	mda5	JJ
cord-254895-ym0jsir5	341	12	pathways	pathway	NNS
cord-254895-ym0jsir5	341	13	for	for	IN
cord-254895-ym0jsir5	341	14	innate	innate	JJ
cord-254895-ym0jsir5	341	15	antiviral	antiviral	JJ
cord-254895-ym0jsir5	341	16	immune	immune	JJ
cord-254895-ym0jsir5	341	17	responses	response	NNS
cord-254895-ym0jsir5	341	18	was	be	VBD
cord-254895-ym0jsir5	341	19	addressed	address	VBN
cord-254895-ym0jsir5	341	20	by	by	IN
cord-254895-ym0jsir5	341	21	the	the	DT
cord-254895-ym0jsir5	341	22	generation	generation	NN
cord-254895-ym0jsir5	341	23	of	of	IN
cord-254895-ym0jsir5	341	24	knockout	knockout	NN
cord-254895-ym0jsir5	341	25	mice	mouse	NNS
cord-254895-ym0jsir5	341	26	.	.	.
cord-254895-ym0jsir5	342	1	The	the	DT
cord-254895-ym0jsir5	342	2	specific	specific	JJ
cord-254895-ym0jsir5	342	3	susceptibility	susceptibility	NN
cord-254895-ym0jsir5	342	4	of	of	IN
cord-254895-ym0jsir5	342	5	MDA5-deficient	MDA5-deficient	NNP
cord-254895-ym0jsir5	342	6	mice	mouse	NNS
cord-254895-ym0jsir5	342	7	to	to	TO
cord-254895-ym0jsir5	342	8	encephalomyocarditis	encephalomyocarditis	VB
cord-254895-ym0jsir5	342	9	virus	virus	NN
cord-254895-ym0jsir5	342	10	(	(	-LRB-
cord-254895-ym0jsir5	342	11	EMCV	EMCV	NNP
cord-254895-ym0jsir5	342	12	)	)	-RRB-
cord-254895-ym0jsir5	342	13	infection	infection	NN
cord-254895-ym0jsir5	342	14	was	be	VBD
cord-254895-ym0jsir5	342	15	shown	show	VBN
cord-254895-ym0jsir5	342	16	in	in	IN
cord-254895-ym0jsir5	342	17	two	two	CD
cord-254895-ym0jsir5	342	18	studies	study	NNS
cord-254895-ym0jsir5	342	19	Gitlin	Gitlin	NNP
cord-254895-ym0jsir5	342	20	et	et	NNP
cord-254895-ym0jsir5	342	21	al	al	NNP
cord-254895-ym0jsir5	342	22	.	.	NNP
cord-254895-ym0jsir5	342	23	,	,	,
cord-254895-ym0jsir5	342	24	2006	2006	CD
cord-254895-ym0jsir5	342	25	)	)	-RRB-
cord-254895-ym0jsir5	342	26	.	.	.
cord-254895-ym0jsir5	343	1	In	in	IN
cord-254895-ym0jsir5	343	2	a	a	DT
cord-254895-ym0jsir5	343	3	direct	direct	JJ
cord-254895-ym0jsir5	343	4	comparison	comparison	NN
cord-254895-ym0jsir5	343	5	with	with	IN
cord-254895-ym0jsir5	343	6	IFNAR	IFNAR	NNP
cord-254895-ym0jsir5	343	7	À	À	NNP
cord-254895-ym0jsir5	343	8	/	/	SYM
cord-254895-ym0jsir5	343	9	À	à	NN
cord-254895-ym0jsir5	343	10	and	and	CC
cord-254895-ym0jsir5	343	11	MyD88	MyD88	NNP
cord-254895-ym0jsir5	343	12	À	à	NN
cord-254895-ym0jsir5	343	13	/	/	SYM
cord-254895-ym0jsir5	343	14	À	à	NN
cord-254895-ym0jsir5	343	15	mice	mouse	NNS
cord-254895-ym0jsir5	343	16	Kato	Kato	NNP
cord-254895-ym0jsir5	343	17	et	et	NNP
cord-254895-ym0jsir5	343	18	al	al	NNP
cord-254895-ym0jsir5	343	19	.	.	.
cord-254895-ym0jsir5	344	1	(	(	-LRB-
cord-254895-ym0jsir5	344	2	2006	2006	CD
cord-254895-ym0jsir5	344	3	)	)	-RRB-
cord-254895-ym0jsir5	344	4	could	could	MD
cord-254895-ym0jsir5	344	5	show	show	VB
cord-254895-ym0jsir5	344	6	that	that	IN
cord-254895-ym0jsir5	344	7	survival	survival	NN
cord-254895-ym0jsir5	344	8	upon	upon	IN
cord-254895-ym0jsir5	344	9	EMCV	EMCV	NNP
cord-254895-ym0jsir5	344	10	infection	infection	NN
cord-254895-ym0jsir5	344	11	is	be	VBZ
cord-254895-ym0jsir5	344	12	as	as	RB
cord-254895-ym0jsir5	344	13	dramatically	dramatically	RB
cord-254895-ym0jsir5	344	14	reduced	reduce	VBN
cord-254895-ym0jsir5	344	15	in	in	IN
cord-254895-ym0jsir5	344	16	MDA5	MDA5	NNP
cord-254895-ym0jsir5	344	17	À	à	NN
cord-254895-ym0jsir5	344	18	/	/	SYM
cord-254895-ym0jsir5	344	19	À	à	NN
cord-254895-ym0jsir5	344	20	mice	mouse	NNS
cord-254895-ym0jsir5	344	21	as	as	IN
cord-254895-ym0jsir5	344	22	in	in	IN
cord-254895-ym0jsir5	344	23	IFNAR	IFNAR	NNP
cord-254895-ym0jsir5	344	24	À	À	NNP
cord-254895-ym0jsir5	344	25	/	/	SYM
cord-254895-ym0jsir5	344	26	À	à	NN
cord-254895-ym0jsir5	344	27	mice	mouse	NNS
cord-254895-ym0jsir5	344	28	.	.	.
cord-254895-ym0jsir5	345	1	MyD88-deficient	MyD88-deficient	NNP
cord-254895-ym0jsir5	345	2	mice	mouse	NNS
cord-254895-ym0jsir5	345	3	were	be	VBD
cord-254895-ym0jsir5	345	4	only	only	RB
cord-254895-ym0jsir5	345	5	slightly	slightly	RB
cord-254895-ym0jsir5	345	6	more	more	RBR
cord-254895-ym0jsir5	345	7	susceptible	susceptible	JJ
cord-254895-ym0jsir5	345	8	to	to	IN
cord-254895-ym0jsir5	345	9	EMCV	EMCV	NNP
cord-254895-ym0jsir5	345	10	infection	infection	NN
cord-254895-ym0jsir5	345	11	than	than	IN
cord-254895-ym0jsir5	345	12	wildtype	wildtype	JJ
cord-254895-ym0jsir5	345	13	mice	mouse	NNS
cord-254895-ym0jsir5	345	14	.	.	.
cord-254895-ym0jsir5	346	1	Survival	survival	NN
cord-254895-ym0jsir5	346	2	after	after	IN
cord-254895-ym0jsir5	346	3	EMCV	EMCV	NNP
cord-254895-ym0jsir5	346	4	infection	infection	NN
cord-254895-ym0jsir5	346	5	was	be	VBD
cord-254895-ym0jsir5	346	6	not	not	RB
cord-254895-ym0jsir5	346	7	affected	affect	VBN
cord-254895-ym0jsir5	346	8	by	by	IN
cord-254895-ym0jsir5	346	9	RIG	rig	NN
cord-254895-ym0jsir5	346	10	-	-	HYPH
cord-254895-ym0jsir5	346	11	I	I	NNP
cord-254895-ym0jsir5	346	12	-	-	HYPH
cord-254895-ym0jsir5	346	13	or	or	CC
cord-254895-ym0jsir5	346	14	TLR3-deficiency	tlr3-deficiency	NN
cord-254895-ym0jsir5	346	15	.	.	.
cord-254895-ym0jsir5	347	1	Studies	study	NNS
cord-254895-ym0jsir5	347	2	in	in	IN
cord-254895-ym0jsir5	347	3	the	the	DT
cord-254895-ym0jsir5	347	4	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	347	5	knockout	knockout	NN
cord-254895-ym0jsir5	347	6	mouse	mouse	NN
cord-254895-ym0jsir5	347	7	confirmed	confirm	VBD
cord-254895-ym0jsir5	347	8	the	the	DT
cord-254895-ym0jsir5	347	9	dramatic	dramatic	JJ
cord-254895-ym0jsir5	347	10	reduction	reduction	NN
cord-254895-ym0jsir5	347	11	in	in	IN
cord-254895-ym0jsir5	347	12	the	the	DT
cord-254895-ym0jsir5	347	13	innate	innate	JJ
cord-254895-ym0jsir5	347	14	immune	immune	JJ
cord-254895-ym0jsir5	347	15	response	response	NN
cord-254895-ym0jsir5	347	16	to	to	IN
cord-254895-ym0jsir5	347	17	EMCV	EMCV	NNP
cord-254895-ym0jsir5	347	18	infection	infection	NN
cord-254895-ym0jsir5	347	19	,	,	,
cord-254895-ym0jsir5	347	20	which	which	WDT
cord-254895-ym0jsir5	347	21	correlated	correlate	VBD
cord-254895-ym0jsir5	347	22	with	with	IN
cord-254895-ym0jsir5	347	23	increased	increase	VBN
cord-254895-ym0jsir5	347	24	viral	viral	JJ
cord-254895-ym0jsir5	347	25	titers	titer	NNS
cord-254895-ym0jsir5	347	26	and	and	CC
cord-254895-ym0jsir5	347	27	decreased	decrease	VBD
cord-254895-ym0jsir5	347	28	survival	survival	NN
cord-254895-ym0jsir5	347	29	,	,	,
cord-254895-ym0jsir5	347	30	in	in	IN
cord-254895-ym0jsir5	347	31	the	the	DT
cord-254895-ym0jsir5	347	32	absence	absence	NN
cord-254895-ym0jsir5	347	33	of	of	IN
cord-254895-ym0jsir5	347	34	the	the	DT
cord-254895-ym0jsir5	347	35	central	central	JJ
cord-254895-ym0jsir5	347	36	downstream	downstream	NN
cord-254895-ym0jsir5	347	37	signaling	signal	VBG
cord-254895-ym0jsir5	347	38	adaptor	adaptor	NN
cord-254895-ym0jsir5	347	39	of	of	IN
cord-254895-ym0jsir5	347	40	MDA5	MDA5	NNP
cord-254895-ym0jsir5	347	41	and	and	CC
cord-254895-ym0jsir5	347	42	RIG	rig	NN
cord-254895-ym0jsir5	347	43	-	-	:
cord-254895-ym0jsir5	347	44	I	i	NN
cord-254895-ym0jsir5	347	45	(	(	-LRB-
cord-254895-ym0jsir5	347	46	Kumar	Kumar	NNP
cord-254895-ym0jsir5	347	47	et	et	NNP
cord-254895-ym0jsir5	347	48	al	al	NNP
cord-254895-ym0jsir5	347	49	.	.	NNP
cord-254895-ym0jsir5	347	50	,	,	,
cord-254895-ym0jsir5	347	51	2006	2006	CD
cord-254895-ym0jsir5	347	52	)	)	-RRB-
cord-254895-ym0jsir5	347	53	.	.	.
cord-254895-ym0jsir5	348	1	Only	only	RB
cord-254895-ym0jsir5	348	2	few	few	JJ
cord-254895-ym0jsir5	348	3	in	in	IN
cord-254895-ym0jsir5	348	4	vivo	vivo	NN
cord-254895-ym0jsir5	348	5	experiments	experiment	NNS
cord-254895-ym0jsir5	348	6	with	with	IN
cord-254895-ym0jsir5	348	7	RIG	rig	NN
cord-254895-ym0jsir5	348	8	-	-	HYPH
cord-254895-ym0jsir5	348	9	Ideficient	Ideficient	NNP
cord-254895-ym0jsir5	348	10	mice	mouse	NNS
cord-254895-ym0jsir5	348	11	have	have	VBP
cord-254895-ym0jsir5	348	12	been	be	VBN
cord-254895-ym0jsir5	348	13	published	publish	VBN
cord-254895-ym0jsir5	348	14	so	so	RB
cord-254895-ym0jsir5	348	15	far	far	RB
cord-254895-ym0jsir5	348	16	,	,	,
cord-254895-ym0jsir5	348	17	because	because	IN
cord-254895-ym0jsir5	348	18	for	for	IN
cord-254895-ym0jsir5	348	19	unknown	unknown	JJ
cord-254895-ym0jsir5	348	20	reasons	reason	NNS
cord-254895-ym0jsir5	348	21	most	most	JJS
cord-254895-ym0jsir5	348	22	of	of	IN
cord-254895-ym0jsir5	348	23	the	the	DT
cord-254895-ym0jsir5	348	24	RIG	rig	NN
cord-254895-ym0jsir5	348	25	-	-	HYPH
cord-254895-ym0jsir5	348	26	I	i	NN
cord-254895-ym0jsir5	348	27	-	-	HYPH
cord-254895-ym0jsir5	348	28	knockout	knockout	NN
cord-254895-ym0jsir5	348	29	mice	mouse	NNS
cord-254895-ym0jsir5	348	30	(	(	-LRB-
cord-254895-ym0jsir5	348	31	on	on	IN
cord-254895-ym0jsir5	348	32	a	a	DT
cord-254895-ym0jsir5	348	33	129	129	CD
cord-254895-ym0jsir5	348	34	/	/	SYM
cord-254895-ym0jsir5	348	35	C57BL/6	c57bl/6	CD
cord-254895-ym0jsir5	348	36	mixed	mixed	JJ
cord-254895-ym0jsir5	348	37	background	background	NN
cord-254895-ym0jsir5	348	38	)	)	-RRB-
cord-254895-ym0jsir5	348	39	died	die	VBD
cord-254895-ym0jsir5	348	40	in	in	IN
cord-254895-ym0jsir5	348	41	utero	utero	NN
cord-254895-ym0jsir5	348	42	or	or	CC
cord-254895-ym0jsir5	348	43	within	within	IN
cord-254895-ym0jsir5	348	44	a	a	DT
cord-254895-ym0jsir5	348	45	few	few	JJ
cord-254895-ym0jsir5	348	46	weeks	week	NNS
cord-254895-ym0jsir5	348	47	after	after	IN
cord-254895-ym0jsir5	348	48	birth	birth	NN
cord-254895-ym0jsir5	348	49	.	.	.
cord-254895-ym0jsir5	349	1	After	after	IN
cord-254895-ym0jsir5	349	2	crossing	cross	VBG
cord-254895-ym0jsir5	349	3	with	with	IN
cord-254895-ym0jsir5	349	4	ICR	ICR	NNP
cord-254895-ym0jsir5	349	5	mice	mouse	NNS
cord-254895-ym0jsir5	350	1	healthy	healthy	JJ
cord-254895-ym0jsir5	350	2	RIG	rig	NN
cord-254895-ym0jsir5	351	1	-I	-I	NNP
cord-254895-ym0jsir5	351	2	À	à	NN
cord-254895-ym0jsir5	351	3	/	/	SYM
cord-254895-ym0jsir5	351	4	À	à	NN
cord-254895-ym0jsir5	351	5	mice	mouse	NNS
cord-254895-ym0jsir5	351	6	were	be	VBD
cord-254895-ym0jsir5	351	7	obtained	obtain	VBN
cord-254895-ym0jsir5	351	8	and	and	CC
cord-254895-ym0jsir5	351	9	compared	compare	VBN
cord-254895-ym0jsir5	351	10	with	with	IN
cord-254895-ym0jsir5	351	11	littermate	littermate	JJ
cord-254895-ym0jsir5	351	12	controls	control	NNS
cord-254895-ym0jsir5	351	13	in	in	IN
cord-254895-ym0jsir5	351	14	the	the	DT
cord-254895-ym0jsir5	351	15	JEV	JEV	NNP
cord-254895-ym0jsir5	351	16	and	and	CC
cord-254895-ym0jsir5	351	17	VSV	VSV	NNP
cord-254895-ym0jsir5	351	18	infection	infection	NN
cord-254895-ym0jsir5	351	19	models	model	NNS
cord-254895-ym0jsir5	351	20	.	.	.
cord-254895-ym0jsir5	352	1	RIG	rig	NN
cord-254895-ym0jsir5	352	2	-	-	HYPH
cord-254895-ym0jsir5	352	3	I	i	NN
cord-254895-ym0jsir5	352	4	À	à	NN
cord-254895-ym0jsir5	352	5	/	/	SYM
cord-254895-ym0jsir5	352	6	À	à	NN
cord-254895-ym0jsir5	352	7	mice	mouse	NNS
cord-254895-ym0jsir5	352	8	were	be	VBD
cord-254895-ym0jsir5	352	9	more	more	RBR
cord-254895-ym0jsir5	352	10	susceptible	susceptible	JJ
cord-254895-ym0jsir5	352	11	to	to	IN
cord-254895-ym0jsir5	352	12	JEV	JEV	NNP
cord-254895-ym0jsir5	352	13	and	and	CC
cord-254895-ym0jsir5	352	14	VSV	VSV	NNP
cord-254895-ym0jsir5	352	15	infection	infection	NN
cord-254895-ym0jsir5	352	16	than	than	IN
cord-254895-ym0jsir5	352	17	wildtype	wildtype	JJ
cord-254895-ym0jsir5	352	18	mice	mouse	NNS
cord-254895-ym0jsir5	352	19	and	and	CC
cord-254895-ym0jsir5	352	20	this	this	DT
cord-254895-ym0jsir5	352	21	correlated	correlate	VBD
cord-254895-ym0jsir5	352	22	with	with	IN
cord-254895-ym0jsir5	352	23	reduced	reduced	JJ
cord-254895-ym0jsir5	352	24	type	type	NN
cord-254895-ym0jsir5	352	25	I	-PRON-	PRP
cord-254895-ym0jsir5	352	26	IFN	IFN	NNP
cord-254895-ym0jsir5	352	27	responses	response	NNS
cord-254895-ym0jsir5	352	28	.	.	.
cord-254895-ym0jsir5	353	1	MyD88-dependent	MyD88-dependent	NNP
cord-254895-ym0jsir5	353	2	type	type	NN
cord-254895-ym0jsir5	354	1	I	-PRON-	PRP
cord-254895-ym0jsir5	354	2	IFN	IFN	NNP
cord-254895-ym0jsir5	354	3	production	production	NN
cord-254895-ym0jsir5	354	4	induced	induce	VBN
cord-254895-ym0jsir5	354	5	by	by	IN
cord-254895-ym0jsir5	354	6	JEV	JEV	NNP
cord-254895-ym0jsir5	354	7	and	and	CC
cord-254895-ym0jsir5	354	8	VSV	VSV	NNP
cord-254895-ym0jsir5	354	9	played	play	VBD
cord-254895-ym0jsir5	354	10	only	only	RB
cord-254895-ym0jsir5	354	11	a	a	DT
cord-254895-ym0jsir5	354	12	minor	minor	JJ
cord-254895-ym0jsir5	354	13	role	role	NN
cord-254895-ym0jsir5	354	14	in	in	IN
cord-254895-ym0jsir5	354	15	these	these	DT
cord-254895-ym0jsir5	354	16	infection	infection	NN
cord-254895-ym0jsir5	354	17	models	model	NNS
cord-254895-ym0jsir5	354	18	.	.	.
cord-254895-ym0jsir5	355	1	In	in	IN
cord-254895-ym0jsir5	355	2	accordance	accordance	NN
cord-254895-ym0jsir5	355	3	with	with	IN
cord-254895-ym0jsir5	355	4	these	these	DT
cord-254895-ym0jsir5	355	5	results	result	NNS
cord-254895-ym0jsir5	355	6	IPS-1-deficient	ips-1-deficient	NN
cord-254895-ym0jsir5	355	7	mice	mouse	NNS
cord-254895-ym0jsir5	355	8	succumbed	succumb	VBD
cord-254895-ym0jsir5	355	9	rapidly	rapidly	RB
cord-254895-ym0jsir5	355	10	to	to	IN
cord-254895-ym0jsir5	355	11	VSV	VSV	NNP
cord-254895-ym0jsir5	355	12	infection	infection	NN
cord-254895-ym0jsir5	356	1	(	(	-LRB-
cord-254895-ym0jsir5	356	2	Sun	Sun	NNP
cord-254895-ym0jsir5	356	3	et	et	NNP
cord-254895-ym0jsir5	356	4	al	al	NNP
cord-254895-ym0jsir5	356	5	.	.	NNP
cord-254895-ym0jsir5	356	6	,	,	,
cord-254895-ym0jsir5	356	7	2006	2006	CD
cord-254895-ym0jsir5	356	8	)	)	-RRB-
cord-254895-ym0jsir5	356	9	.	.	.
cord-254895-ym0jsir5	357	1	As	as	IN
cord-254895-ym0jsir5	357	2	pointed	point	VBN
cord-254895-ym0jsir5	357	3	out	out	RP
cord-254895-ym0jsir5	357	4	by	by	IN
cord-254895-ym0jsir5	357	5	the	the	DT
cord-254895-ym0jsir5	357	6	study	study	NN
cord-254895-ym0jsir5	357	7	of	of	IN
cord-254895-ym0jsir5	357	8	Sun	Sun	NNP
cord-254895-ym0jsir5	357	9	et	et	NNP
cord-254895-ym0jsir5	357	10	al	al	NNP
cord-254895-ym0jsir5	357	11	.	.	.
cord-254895-ym0jsir5	358	1	(	(	-LRB-
cord-254895-ym0jsir5	358	2	2006	2006	CD
cord-254895-ym0jsir5	358	3	)	)	-RRB-
cord-254895-ym0jsir5	358	4	,	,	,
cord-254895-ym0jsir5	358	5	type	type	NN
cord-254895-ym0jsir5	358	6	I	-PRON-	PRP
cord-254895-ym0jsir5	358	7	IFN	IFN	NNP
cord-254895-ym0jsir5	358	8	responses	response	NNS
cord-254895-ym0jsir5	358	9	to	to	IN
cord-254895-ym0jsir5	358	10	systemic	systemic	JJ
cord-254895-ym0jsir5	358	11	VSV	VSV	NNP
cord-254895-ym0jsir5	358	12	infection	infection	NN
cord-254895-ym0jsir5	358	13	were	be	VBD
cord-254895-ym0jsir5	358	14	not	not	RB
cord-254895-ym0jsir5	358	15	entirely	entirely	RB
cord-254895-ym0jsir5	358	16	abrogated	abrogate	VBN
cord-254895-ym0jsir5	358	17	in	in	IN
cord-254895-ym0jsir5	358	18	IPS-1-deficient	ips-1-deficient	NN
cord-254895-ym0jsir5	358	19	mice	mouse	NNS
cord-254895-ym0jsir5	358	20	,	,	,
cord-254895-ym0jsir5	358	21	suggesting	suggest	VBG
cord-254895-ym0jsir5	358	22	that	that	IN
cord-254895-ym0jsir5	358	23	TLR7-dependent	TLR7-dependent	NNP
cord-254895-ym0jsir5	358	24	pDC	pDC	NNP
cord-254895-ym0jsir5	358	25	-	-	HYPH
cord-254895-ym0jsir5	358	26	mediated	mediate	VBN
cord-254895-ym0jsir5	358	27	type	type	NN
cord-254895-ym0jsir5	358	28	I	-PRON-	PRP
cord-254895-ym0jsir5	358	29	IFN	IFN	NNP
cord-254895-ym0jsir5	358	30	release	release	VBP
cord-254895-ym0jsir5	358	31	at	at	IN
cord-254895-ym0jsir5	358	32	least	least	JJS
cord-254895-ym0jsir5	358	33	partially	partially	RB
cord-254895-ym0jsir5	358	34	compensates	compensate	VBZ
cord-254895-ym0jsir5	358	35	for	for	IN
cord-254895-ym0jsir5	358	36	the	the	DT
cord-254895-ym0jsir5	358	37	dysfunctional	dysfunctional	JJ
cord-254895-ym0jsir5	358	38	RNA	RNA	NNP
cord-254895-ym0jsir5	358	39	helicase	helicase	NN
cord-254895-ym0jsir5	358	40	pathway	pathway	NN
cord-254895-ym0jsir5	358	41	,	,	,
cord-254895-ym0jsir5	358	42	but	but	CC
cord-254895-ym0jsir5	358	43	this	this	DT
cord-254895-ym0jsir5	358	44	compensatory	compensatory	JJ
cord-254895-ym0jsir5	358	45	mechanism	mechanism	NN
cord-254895-ym0jsir5	358	46	can	can	MD
cord-254895-ym0jsir5	358	47	not	not	RB
cord-254895-ym0jsir5	358	48	prevent	prevent	VB
cord-254895-ym0jsir5	358	49	death	death	NN
cord-254895-ym0jsir5	358	50	after	after	IN
cord-254895-ym0jsir5	358	51	infection	infection	NN
cord-254895-ym0jsir5	358	52	with	with	IN
cord-254895-ym0jsir5	358	53	high	high	JJ
cord-254895-ym0jsir5	358	54	doses	dose	NNS
cord-254895-ym0jsir5	358	55	of	of	IN
cord-254895-ym0jsir5	358	56	VSV	VSV	NNP
cord-254895-ym0jsir5	358	57	.	.	.
cord-254895-ym0jsir5	359	1	The	the	DT
cord-254895-ym0jsir5	359	2	RNA	RNA	NNP
cord-254895-ym0jsir5	359	3	helicase	helicase	NN
cord-254895-ym0jsir5	359	4	pathway	pathway	NN
cord-254895-ym0jsir5	359	5	as	as	IN
cord-254895-ym0jsir5	359	6	target	target	NN
cord-254895-ym0jsir5	359	7	for	for	IN
cord-254895-ym0jsir5	359	8	viral	viral	JJ
cord-254895-ym0jsir5	359	9	immune	immune	JJ
cord-254895-ym0jsir5	359	10	evasion	evasion	NN
cord-254895-ym0jsir5	359	11	strategies	strategy	NNS
cord-254895-ym0jsir5	359	12	Viruses	virus	NNS
cord-254895-ym0jsir5	359	13	have	have	VBP
cord-254895-ym0jsir5	359	14	adapted	adapt	VBN
cord-254895-ym0jsir5	359	15	strategies	strategy	NNS
cord-254895-ym0jsir5	359	16	to	to	TO
cord-254895-ym0jsir5	359	17	evade	evade	VB
cord-254895-ym0jsir5	359	18	or	or	CC
cord-254895-ym0jsir5	359	19	inhibit	inhibit	VB
cord-254895-ym0jsir5	359	20	key	key	JJ
cord-254895-ym0jsir5	359	21	elements	element	NNS
cord-254895-ym0jsir5	359	22	of	of	IN
cord-254895-ym0jsir5	359	23	antiviral	antiviral	JJ
cord-254895-ym0jsir5	359	24	immunity	immunity	NN
cord-254895-ym0jsir5	359	25	.	.	.
cord-254895-ym0jsir5	360	1	A	a	DT
cord-254895-ym0jsir5	360	2	number	number	NN
cord-254895-ym0jsir5	360	3	of	of	IN
cord-254895-ym0jsir5	360	4	viral	viral	JJ
cord-254895-ym0jsir5	360	5	proteins	protein	NNS
cord-254895-ym0jsir5	360	6	inhibit	inhibit	VBP
cord-254895-ym0jsir5	360	7	host	host	NN
cord-254895-ym0jsir5	360	8	innate	innate	JJ
cord-254895-ym0jsir5	360	9	immune	immune	JJ
cord-254895-ym0jsir5	360	10	responses	response	NNS
cord-254895-ym0jsir5	360	11	,	,	,
cord-254895-ym0jsir5	360	12	prevent	prevent	VBP
cord-254895-ym0jsir5	360	13	viral	viral	JJ
cord-254895-ym0jsir5	360	14	antigen	antigen	NN
cord-254895-ym0jsir5	360	15	presentation	presentation	NN
cord-254895-ym0jsir5	360	16	and	and	CC
cord-254895-ym0jsir5	360	17	abrogate	abrogate	VB
cord-254895-ym0jsir5	360	18	induction	induction	NN
cord-254895-ym0jsir5	360	19	of	of	IN
cord-254895-ym0jsir5	360	20	cell	cell	NN
cord-254895-ym0jsir5	360	21	death	death	NN
cord-254895-ym0jsir5	360	22	.	.	.
cord-254895-ym0jsir5	361	1	Since	since	IN
cord-254895-ym0jsir5	361	2	the	the	DT
cord-254895-ym0jsir5	361	3	cytoplasmic	cytoplasmic	JJ
cord-254895-ym0jsir5	361	4	RIG	rig	NN
cord-254895-ym0jsir5	361	5	-	-	:
cord-254895-ym0jsir5	361	6	I	I	NNP
cord-254895-ym0jsir5	361	7	/	/	SYM
cord-254895-ym0jsir5	361	8	MDA5	mda5	JJ
cord-254895-ym0jsir5	361	9	system	system	NN
cord-254895-ym0jsir5	361	10	is	be	VBZ
cord-254895-ym0jsir5	361	11	critical	critical	JJ
cord-254895-ym0jsir5	361	12	for	for	IN
cord-254895-ym0jsir5	361	13	host	host	NN
cord-254895-ym0jsir5	361	14	defense	defense	NN
cord-254895-ym0jsir5	361	15	against	against	IN
cord-254895-ym0jsir5	361	16	RNA	RNA	NNP
cord-254895-ym0jsir5	361	17	viruses	virus	NNS
cord-254895-ym0jsir5	361	18	,	,	,
cord-254895-ym0jsir5	361	19	the	the	DT
cord-254895-ym0jsir5	361	20	signaling	signal	VBG
cord-254895-ym0jsir5	361	21	cascades	cascade	NNS
cord-254895-ym0jsir5	361	22	induced	induce	VBN
cord-254895-ym0jsir5	361	23	by	by	IN
cord-254895-ym0jsir5	361	24	these	these	DT
cord-254895-ym0jsir5	361	25	sensors	sensor	NNS
cord-254895-ym0jsir5	361	26	are	be	VBP
cord-254895-ym0jsir5	361	27	also	also	RB
cord-254895-ym0jsir5	361	28	targeted	target	VBN
cord-254895-ym0jsir5	361	29	by	by	IN
cord-254895-ym0jsir5	361	30	viruses	virus	NNS
cord-254895-ym0jsir5	361	31	.	.	.
cord-254895-ym0jsir5	362	1	Various	various	JJ
cord-254895-ym0jsir5	362	2	proteins	protein	NNS
cord-254895-ym0jsir5	362	3	encoded	encode	VBN
cord-254895-ym0jsir5	362	4	by	by	IN
cord-254895-ym0jsir5	362	5	RNA	RNA	NNP
cord-254895-ym0jsir5	362	6	viruses	virus	NNS
cord-254895-ym0jsir5	362	7	have	have	VBP
cord-254895-ym0jsir5	362	8	been	be	VBN
cord-254895-ym0jsir5	362	9	shown	show	VBN
cord-254895-ym0jsir5	362	10	to	to	TO
cord-254895-ym0jsir5	362	11	antagonize	antagonize	VB
cord-254895-ym0jsir5	362	12	the	the	DT
cord-254895-ym0jsir5	362	13	cytoplasmic	cytoplasmic	JJ
cord-254895-ym0jsir5	362	14	RNA	RNA	NNP
cord-254895-ym0jsir5	362	15	helicase	helicase	NN
cord-254895-ym0jsir5	362	16	pathways	pathway	NNS
cord-254895-ym0jsir5	362	17	.	.	.
cord-254895-ym0jsir5	363	1	IFN	IFN	NNP
cord-254895-ym0jsir5	363	2	antagonists	antagonist	NNS
cord-254895-ym0jsir5	363	3	of	of	IN
cord-254895-ym0jsir5	363	4	negative	negative	JJ
cord-254895-ym0jsir5	363	5	strand	strand	NN
cord-254895-ym0jsir5	363	6	RNA	RNA	NNP
cord-254895-ym0jsir5	363	7	viruses	virus	NNS
cord-254895-ym0jsir5	363	8	can	can	MD
cord-254895-ym0jsir5	363	9	interfere	interfere	VB
cord-254895-ym0jsir5	363	10	with	with	IN
cord-254895-ym0jsir5	363	11	this	this	DT
cord-254895-ym0jsir5	363	12	pathway	pathway	NN
cord-254895-ym0jsir5	363	13	by	by	IN
cord-254895-ym0jsir5	363	14	hiding	hide	VBG
cord-254895-ym0jsir5	363	15	their	-PRON-	PRP$
cord-254895-ym0jsir5	363	16	RNA	RNA	NNP
cord-254895-ym0jsir5	363	17	(	(	-LRB-
cord-254895-ym0jsir5	363	18	Influenza	Influenza	NNP
cord-254895-ym0jsir5	363	19	A	a	DT
cord-254895-ym0jsir5	363	20	virus	virus	NN
cord-254895-ym0jsir5	363	21	NS1	ns1	CD
cord-254895-ym0jsir5	363	22	protein	protein	NN
cord-254895-ym0jsir5	363	23	)	)	-RRB-
cord-254895-ym0jsir5	363	24	or	or	CC
cord-254895-ym0jsir5	363	25	binding	bind	VBG
cord-254895-ym0jsir5	363	26	to	to	IN
cord-254895-ym0jsir5	363	27	the	the	DT
cord-254895-ym0jsir5	363	28	dsRNA	dsrna	NN
cord-254895-ym0jsir5	363	29	receptor	receptor	NN
cord-254895-ym0jsir5	363	30	(	(	-LRB-
cord-254895-ym0jsir5	363	31	Paramyxovirus	Paramyxovirus	NNP
cord-254895-ym0jsir5	363	32	V	V	NNP
cord-254895-ym0jsir5	363	33	proteins	protein	NNS
cord-254895-ym0jsir5	363	34	)	)	-RRB-
cord-254895-ym0jsir5	363	35	or	or	CC
cord-254895-ym0jsir5	363	36	preventing	prevent	VBG
cord-254895-ym0jsir5	363	37	activation	activation	NN
cord-254895-ym0jsir5	363	38	of	of	IN
cord-254895-ym0jsir5	363	39	downstream	downstream	JJ
cord-254895-ym0jsir5	363	40	factors	factor	NNS
cord-254895-ym0jsir5	363	41	such	such	JJ
cord-254895-ym0jsir5	363	42	as	as	IN
cord-254895-ym0jsir5	363	43	IRF3	IRF3	NNP
cord-254895-ym0jsir5	364	1	(	(	-LRB-
cord-254895-ym0jsir5	364	2	Ebola	Ebola	NNP
cord-254895-ym0jsir5	364	3	virus	virus	NN
cord-254895-ym0jsir5	364	4	VP35	VP35	NNP
cord-254895-ym0jsir5	364	5	,	,	,
cord-254895-ym0jsir5	364	6	Rhabdovirus	Rhabdovirus	NNP
cord-254895-ym0jsir5	364	7	P	P	NNP
cord-254895-ym0jsir5	364	8	)	)	-RRB-
cord-254895-ym0jsir5	364	9	,	,	,
cord-254895-ym0jsir5	364	10	respectively	respectively	RB
cord-254895-ym0jsir5	364	11	.	.	.
cord-254895-ym0jsir5	365	1	The	the	DT
cord-254895-ym0jsir5	365	2	non	non	JJ
cord-254895-ym0jsir5	365	3	-	-	JJ
cord-254895-ym0jsir5	365	4	structural	structural	JJ
cord-254895-ym0jsir5	365	5	protein	protein	NN
cord-254895-ym0jsir5	365	6	1	1	CD
cord-254895-ym0jsir5	365	7	(	(	-LRB-
cord-254895-ym0jsir5	365	8	NS1	ns1	NN
cord-254895-ym0jsir5	365	9	)	)	-RRB-
cord-254895-ym0jsir5	365	10	of	of	IN
cord-254895-ym0jsir5	365	11	the	the	DT
cord-254895-ym0jsir5	365	12	Influenza	Influenza	NNP
cord-254895-ym0jsir5	365	13	viruses	virus	NNS
cord-254895-ym0jsir5	365	14	is	be	VBZ
cord-254895-ym0jsir5	365	15	a	a	DT
cord-254895-ym0jsir5	365	16	dsRNA	dsrna	RB
cord-254895-ym0jsir5	365	17	-	-	HYPH
cord-254895-ym0jsir5	365	18	binding	bind	VBG
cord-254895-ym0jsir5	365	19	protein	protein	NN
cord-254895-ym0jsir5	365	20	that	that	WDT
cord-254895-ym0jsir5	365	21	acts	act	VBZ
cord-254895-ym0jsir5	365	22	as	as	IN
cord-254895-ym0jsir5	365	23	an	an	DT
cord-254895-ym0jsir5	365	24	IFN	IFN	NNP
cord-254895-ym0jsir5	365	25	antagonist	antagonist	NN
cord-254895-ym0jsir5	365	26	(	(	-LRB-
cord-254895-ym0jsir5	365	27	Garcia	Garcia	NNP
cord-254895-ym0jsir5	365	28	-	-	HYPH
cord-254895-ym0jsir5	365	29	Sastre	Sastre	NNP
cord-254895-ym0jsir5	365	30	et	et	NNP
cord-254895-ym0jsir5	365	31	al	al	NNP
cord-254895-ym0jsir5	365	32	.	.	NNP
cord-254895-ym0jsir5	365	33	,	,	,
cord-254895-ym0jsir5	365	34	1998	1998	CD
cord-254895-ym0jsir5	365	35	)	)	-RRB-
cord-254895-ym0jsir5	365	36	.	.	.
cord-254895-ym0jsir5	366	1	By	by	IN
cord-254895-ym0jsir5	366	2	binding	bind	VBG
cord-254895-ym0jsir5	366	3	to	to	IN
cord-254895-ym0jsir5	366	4	dsRNA	dsrna	NN
cord-254895-ym0jsir5	366	5	NS1	NS1	NNS
cord-254895-ym0jsir5	366	6	disguises	disguise	VBZ
cord-254895-ym0jsir5	366	7	the	the	DT
cord-254895-ym0jsir5	366	8	viral	viral	JJ
cord-254895-ym0jsir5	366	9	dsRNA	dsrna	NN
cord-254895-ym0jsir5	366	10	pattern	pattern	NN
cord-254895-ym0jsir5	366	11	from	from	IN
cord-254895-ym0jsir5	366	12	the	the	DT
cord-254895-ym0jsir5	366	13	cytoplasmic	cytoplasmic	JJ
cord-254895-ym0jsir5	366	14	receptors	receptor	NNS
cord-254895-ym0jsir5	366	15	and	and	CC
cord-254895-ym0jsir5	366	16	inhibits	inhibit	VBZ
cord-254895-ym0jsir5	366	17	IFN	IFN	NNP
cord-254895-ym0jsir5	366	18	-	-	HYPH
cord-254895-ym0jsir5	366	19	a	a	DT
cord-254895-ym0jsir5	366	20	/	/	SYM
cord-254895-ym0jsir5	366	21	INF	inf	NN
cord-254895-ym0jsir5	366	22	-	-	HYPH
cord-254895-ym0jsir5	366	23	b	b	NN
cord-254895-ym0jsir5	366	24	induction	induction	NN
cord-254895-ym0jsir5	366	25	via	via	IN
cord-254895-ym0jsir5	366	26	IRF3	IRF3	NNP
cord-254895-ym0jsir5	367	1	(	(	-LRB-
cord-254895-ym0jsir5	367	2	Garcia	Garcia	NNP
cord-254895-ym0jsir5	367	3	-	-	HYPH
cord-254895-ym0jsir5	367	4	Sastre	Sastre	NNP
cord-254895-ym0jsir5	367	5	,	,	,
cord-254895-ym0jsir5	367	6	2004	2004	CD
cord-254895-ym0jsir5	367	7	;	;	:
cord-254895-ym0jsir5	368	1	Talon	Talon	NNP
cord-254895-ym0jsir5	368	2	et	et	NNP
cord-254895-ym0jsir5	368	3	al	al	NNP
cord-254895-ym0jsir5	368	4	.	.	NNP
cord-254895-ym0jsir5	368	5	,	,	,
cord-254895-ym0jsir5	368	6	2000	2000	CD
cord-254895-ym0jsir5	368	7	)	)	-RRB-
cord-254895-ym0jsir5	368	8	.	.	.
cord-254895-ym0jsir5	369	1	RIG	rig	NN
cord-254895-ym0jsir5	369	2	-	-	:
cord-254895-ym0jsir5	369	3	I	-PRON-	PRP
cord-254895-ym0jsir5	369	4	was	be	VBD
cord-254895-ym0jsir5	369	5	recently	recently	RB
cord-254895-ym0jsir5	369	6	demonstrated	demonstrate	VBN
cord-254895-ym0jsir5	369	7	to	to	TO
cord-254895-ym0jsir5	369	8	be	be	VB
cord-254895-ym0jsir5	369	9	essential	essential	JJ
cord-254895-ym0jsir5	369	10	for	for	IN
cord-254895-ym0jsir5	369	11	the	the	DT
cord-254895-ym0jsir5	369	12	induction	induction	NN
cord-254895-ym0jsir5	369	13	of	of	IN
cord-254895-ym0jsir5	369	14	IFN	IFN	NNP
cord-254895-ym0jsir5	369	15	-	-	HYPH
cord-254895-ym0jsir5	369	16	b	b	NNP
cord-254895-ym0jsir5	369	17	by	by	IN
cord-254895-ym0jsir5	369	18	Influenza	Influenza	NNP
cord-254895-ym0jsir5	369	19	virus	virus	NN
cord-254895-ym0jsir5	369	20	in	in	IN
cord-254895-ym0jsir5	369	21	murine	murine	JJ
cord-254895-ym0jsir5	369	22	cells	cell	NNS
cord-254895-ym0jsir5	369	23	.	.	.
cord-254895-ym0jsir5	370	1	Furthermore	furthermore	RB
cord-254895-ym0jsir5	370	2	,	,	,
cord-254895-ym0jsir5	370	3	it	-PRON-	PRP
cord-254895-ym0jsir5	370	4	was	be	VBD
cord-254895-ym0jsir5	370	5	observed	observe	VBN
cord-254895-ym0jsir5	370	6	that	that	IN
cord-254895-ym0jsir5	370	7	NS1	ns1	NN
cord-254895-ym0jsir5	370	8	colocalizes	colocalizes	NNP
cord-254895-ym0jsir5	370	9	with	with	IN
cord-254895-ym0jsir5	370	10	RIG	rig	NN
cord-254895-ym0jsir5	370	11	-	-	:
cord-254895-ym0jsir5	370	12	I	i	NN
cord-254895-ym0jsir5	370	13	(	(	-LRB-
cord-254895-ym0jsir5	370	14	Mibayashi	Mibayashi	NNP
cord-254895-ym0jsir5	370	15	et	et	FW
cord-254895-ym0jsir5	370	16	al	al	NNP
cord-254895-ym0jsir5	370	17	.	.	NNP
cord-254895-ym0jsir5	370	18	,	,	,
cord-254895-ym0jsir5	370	19	2007	2007	CD
cord-254895-ym0jsir5	370	20	)	)	-RRB-
cord-254895-ym0jsir5	370	21	,	,	,
cord-254895-ym0jsir5	370	22	suggesting	suggest	VBG
cord-254895-ym0jsir5	370	23	that	that	IN
cord-254895-ym0jsir5	370	24	NS1	ns1	CD
cord-254895-ym0jsir5	370	25	forms	form	VBZ
cord-254895-ym0jsir5	370	26	a	a	DT
cord-254895-ym0jsir5	370	27	complex	complex	NN
cord-254895-ym0jsir5	370	28	with	with	IN
cord-254895-ym0jsir5	370	29	RIG	rig	NN
cord-254895-ym0jsir5	370	30	-	-	:
cord-254895-ym0jsir5	370	31	I	I	NNP
cord-254895-ym0jsir5	370	32	and	and	CC
cord-254895-ym0jsir5	370	33	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	370	34	during	during	IN
cord-254895-ym0jsir5	370	35	viral	viral	JJ
cord-254895-ym0jsir5	370	36	infection	infection	NN
cord-254895-ym0jsir5	370	37	,	,	,
cord-254895-ym0jsir5	370	38	resulting	result	VBG
cord-254895-ym0jsir5	370	39	in	in	IN
cord-254895-ym0jsir5	370	40	inhibition	inhibition	NN
cord-254895-ym0jsir5	370	41	of	of	IN
cord-254895-ym0jsir5	370	42	further	further	JJ
cord-254895-ym0jsir5	370	43	downstream	downstream	JJ
cord-254895-ym0jsir5	370	44	signaling	signaling	NN
cord-254895-ym0jsir5	370	45	.	.	.
cord-254895-ym0jsir5	371	1	Respiratory	respiratory	JJ
cord-254895-ym0jsir5	371	2	syncytial	syncytial	JJ
cord-254895-ym0jsir5	371	3	virus	virus	NN
cord-254895-ym0jsir5	371	4	(	(	-LRB-
cord-254895-ym0jsir5	371	5	RSV	RSV	NNP
cord-254895-ym0jsir5	371	6	)	)	-RRB-
cord-254895-ym0jsir5	371	7	specifically	specifically	RB
cord-254895-ym0jsir5	371	8	interferes	interfere	VBZ
cord-254895-ym0jsir5	371	9	with	with	IN
cord-254895-ym0jsir5	371	10	IRF3	IRF3	NNP
cord-254895-ym0jsir5	371	11	activation	activation	NN
cord-254895-ym0jsir5	371	12	and	and	CC
cord-254895-ym0jsir5	371	13	IFN	IFN	NNP
cord-254895-ym0jsir5	371	14	-	-	HYPH
cord-254895-ym0jsir5	371	15	b	b	NNP
cord-254895-ym0jsir5	371	16	response	response	NN
cord-254895-ym0jsir5	371	17	:	:	:
cord-254895-ym0jsir5	371	18	Two	two	CD
cord-254895-ym0jsir5	371	19	viral	viral	JJ
cord-254895-ym0jsir5	371	20	proteins	protein	NNS
cord-254895-ym0jsir5	371	21	of	of	IN
cord-254895-ym0jsir5	371	22	RSV	RSV	NNP
cord-254895-ym0jsir5	371	23	,	,	,
cord-254895-ym0jsir5	371	24	NS1	ns1	NN
cord-254895-ym0jsir5	371	25	and	and	CC
cord-254895-ym0jsir5	371	26	NS2	NS2	NNP
cord-254895-ym0jsir5	371	27	,	,	,
cord-254895-ym0jsir5	371	28	are	be	VBP
cord-254895-ym0jsir5	371	29	involved	involve	VBN
cord-254895-ym0jsir5	371	30	in	in	IN
cord-254895-ym0jsir5	371	31	blocking	block	VBG
cord-254895-ym0jsir5	371	32	the	the	DT
cord-254895-ym0jsir5	371	33	pathway	pathway	NN
cord-254895-ym0jsir5	371	34	leading	lead	VBG
cord-254895-ym0jsir5	371	35	to	to	IN
cord-254895-ym0jsir5	371	36	IRF3	IRF3	NNP
cord-254895-ym0jsir5	371	37	phosphorylation	phosphorylation	NN
cord-254895-ym0jsir5	371	38	,	,	,
cord-254895-ym0jsir5	371	39	although	although	IN
cord-254895-ym0jsir5	371	40	the	the	DT
cord-254895-ym0jsir5	371	41	activation	activation	NN
cord-254895-ym0jsir5	371	42	of	of	IN
cord-254895-ym0jsir5	371	43	NFkB	NFkB	NNP
cord-254895-ym0jsir5	371	44	and	and	CC
cord-254895-ym0jsir5	371	45	AP-1	AP-1	NNP
cord-254895-ym0jsir5	371	46	is	be	VBZ
cord-254895-ym0jsir5	371	47	unaffected	unaffected	JJ
cord-254895-ym0jsir5	372	1	(	(	-LRB-
cord-254895-ym0jsir5	372	2	Bossert	Bossert	NNP
cord-254895-ym0jsir5	372	3	et	et	NNP
cord-254895-ym0jsir5	372	4	al	al	NNP
cord-254895-ym0jsir5	372	5	.	.	NNP
cord-254895-ym0jsir5	372	6	,	,	,
cord-254895-ym0jsir5	372	7	2003	2003	CD
cord-254895-ym0jsir5	372	8	)	)	-RRB-
cord-254895-ym0jsir5	372	9	.	.	.
cord-254895-ym0jsir5	373	1	IRF3	irf3	JJ
cord-254895-ym0jsir5	373	2	phosphorylation	phosphorylation	NN
cord-254895-ym0jsir5	373	3	by	by	IN
cord-254895-ym0jsir5	373	4	TBK1	TBK1	NNP
cord-254895-ym0jsir5	373	5	was	be	VBD
cord-254895-ym0jsir5	373	6	identified	identify	VBN
cord-254895-ym0jsir5	373	7	as	as	IN
cord-254895-ym0jsir5	373	8	target	target	NN
cord-254895-ym0jsir5	373	9	of	of	IN
cord-254895-ym0jsir5	373	10	the	the	DT
cord-254895-ym0jsir5	373	11	Rabies	Rabies	NNP
cord-254895-ym0jsir5	373	12	virus	virus	NN
cord-254895-ym0jsir5	373	13	phosphoprotein	phosphoprotein	NN
cord-254895-ym0jsir5	373	14	P	p	NN
cord-254895-ym0jsir5	373	15	(	(	-LRB-
cord-254895-ym0jsir5	373	16	Brzozka	Brzozka	NNP
cord-254895-ym0jsir5	373	17	et	et	NNP
cord-254895-ym0jsir5	373	18	al	al	NNP
cord-254895-ym0jsir5	373	19	.	.	NNP
cord-254895-ym0jsir5	373	20	,	,	,
cord-254895-ym0jsir5	373	21	2005	2005	CD
cord-254895-ym0jsir5	373	22	)	)	-RRB-
cord-254895-ym0jsir5	373	23	.	.	.
cord-254895-ym0jsir5	374	1	Recently	recently	RB
cord-254895-ym0jsir5	374	2	it	-PRON-	PRP
cord-254895-ym0jsir5	374	3	was	be	VBD
cord-254895-ym0jsir5	374	4	shown	show	VBN
cord-254895-ym0jsir5	374	5	that	that	IN
cord-254895-ym0jsir5	374	6	the	the	DT
cord-254895-ym0jsir5	374	7	NY-1	NY-1	NNP
cord-254895-ym0jsir5	374	8	Hantavirus	Hantavirus	NNP
cord-254895-ym0jsir5	374	9	G1	G1	NNP
cord-254895-ym0jsir5	374	10	cytoplasmic	cytoplasmic	JJ
cord-254895-ym0jsir5	374	11	tail	tail	NN
cord-254895-ym0jsir5	374	12	inhibits	inhibit	VBZ
cord-254895-ym0jsir5	374	13	RIG	rig	NN
cord-254895-ym0jsir5	374	14	-	-	HYPH
cord-254895-ym0jsir5	374	15	I	i	NN
cord-254895-ym0jsir5	374	16	-	-	HYPH
cord-254895-ym0jsir5	374	17	and	and	CC
cord-254895-ym0jsir5	374	18	TBK1-directed	tbk1-directed	JJ
cord-254895-ym0jsir5	374	19	interferon	interferon	NN
cord-254895-ym0jsir5	374	20	responses	response	NNS
cord-254895-ym0jsir5	374	21	(	(	-LRB-
cord-254895-ym0jsir5	375	1	Alff	Alff	NNP
cord-254895-ym0jsir5	375	2	et	et	NNP
cord-254895-ym0jsir5	375	3	al	al	NNP
cord-254895-ym0jsir5	375	4	.	.	NNP
cord-254895-ym0jsir5	375	5	,	,	,
cord-254895-ym0jsir5	375	6	2006	2006	CD
cord-254895-ym0jsir5	375	7	)	)	-RRB-
cord-254895-ym0jsir5	375	8	.	.	.
cord-254895-ym0jsir5	376	1	The	the	DT
cord-254895-ym0jsir5	376	2	V	v	NN
cord-254895-ym0jsir5	376	3	proteins	protein	NNS
cord-254895-ym0jsir5	376	4	of	of	IN
cord-254895-ym0jsir5	376	5	paramyxoviruses	paramyxovirus	NNS
cord-254895-ym0jsir5	376	6	target	target	VBP
cord-254895-ym0jsir5	376	7	MDA5	MDA5	NNP
cord-254895-ym0jsir5	376	8	,	,	,
cord-254895-ym0jsir5	376	9	but	but	CC
cord-254895-ym0jsir5	376	10	not	not	RB
cord-254895-ym0jsir5	376	11	RIG	rig	NN
cord-254895-ym0jsir5	376	12	-	-	HYPH
cord-254895-ym0jsir5	376	13	I.	i.	NN
cord-254895-ym0jsir5	377	1	The	the	DT
cord-254895-ym0jsir5	377	2	V	v	NN
cord-254895-ym0jsir5	377	3	proteins	protein	NNS
cord-254895-ym0jsir5	377	4	of	of	IN
cord-254895-ym0jsir5	377	5	this	this	DT
cord-254895-ym0jsir5	377	6	diverse	diverse	JJ
cord-254895-ym0jsir5	377	7	group	group	NN
cord-254895-ym0jsir5	377	8	of	of	IN
cord-254895-ym0jsir5	377	9	viruses	virus	NNS
cord-254895-ym0jsir5	377	10	bind	bind	VBP
cord-254895-ym0jsir5	377	11	MDA5	MDA5	NNP
cord-254895-ym0jsir5	377	12	via	via	IN
cord-254895-ym0jsir5	377	13	their	-PRON-	PRP$
cord-254895-ym0jsir5	377	14	highly	highly	RB
cord-254895-ym0jsir5	377	15	conserved	conserve	VBN
cord-254895-ym0jsir5	377	16	cysteinerich	cysteinerich	NN
cord-254895-ym0jsir5	377	17	C	c	NN
cord-254895-ym0jsir5	377	18	-	-	HYPH
cord-254895-ym0jsir5	377	19	terminal	terminal	NN
cord-254895-ym0jsir5	377	20	domain	domain	NN
cord-254895-ym0jsir5	377	21	.	.	.
cord-254895-ym0jsir5	378	1	This	this	DT
cord-254895-ym0jsir5	378	2	suggests	suggest	VBZ
cord-254895-ym0jsir5	378	3	that	that	IN
cord-254895-ym0jsir5	378	4	paramyxoviruses	paramyxovirus	NNS
cord-254895-ym0jsir5	378	5	use	use	VBP
cord-254895-ym0jsir5	378	6	this	this	DT
cord-254895-ym0jsir5	378	7	interaction	interaction	NN
cord-254895-ym0jsir5	378	8	to	to	TO
cord-254895-ym0jsir5	378	9	reduce	reduce	VB
cord-254895-ym0jsir5	378	10	the	the	DT
cord-254895-ym0jsir5	378	11	amount	amount	NN
cord-254895-ym0jsir5	378	12	of	of	IN
cord-254895-ym0jsir5	378	13	IFN	IFN	NNP
cord-254895-ym0jsir5	378	14	released	release	VBN
cord-254895-ym0jsir5	378	15	by	by	IN
cord-254895-ym0jsir5	378	16	infected	infected	JJ
cord-254895-ym0jsir5	378	17	cells	cell	NNS
cord-254895-ym0jsir5	379	1	(	(	-LRB-
cord-254895-ym0jsir5	379	2	Andrejeva	Andrejeva	NNP
cord-254895-ym0jsir5	379	3	et	et	NNP
cord-254895-ym0jsir5	379	4	al	al	NNP
cord-254895-ym0jsir5	379	5	.	.	NNP
cord-254895-ym0jsir5	379	6	,	,	,
cord-254895-ym0jsir5	379	7	2004	2004	CD
cord-254895-ym0jsir5	379	8	;	;	:
cord-254895-ym0jsir5	380	1	Childs	Childs	NNP
cord-254895-ym0jsir5	380	2	et	et	NNP
cord-254895-ym0jsir5	380	3	al	al	NNP
cord-254895-ym0jsir5	380	4	.	.	NNP
cord-254895-ym0jsir5	380	5	,	,	,
cord-254895-ym0jsir5	380	6	2007	2007	CD
cord-254895-ym0jsir5	380	7	)	)	-RRB-
cord-254895-ym0jsir5	380	8	.	.	.
cord-254895-ym0jsir5	381	1	Furthermore	furthermore	RB
cord-254895-ym0jsir5	381	2	,	,	,
cord-254895-ym0jsir5	381	3	it	-PRON-	PRP
cord-254895-ym0jsir5	381	4	was	be	VBD
cord-254895-ym0jsir5	381	5	shown	show	VBN
cord-254895-ym0jsir5	381	6	that	that	IN
cord-254895-ym0jsir5	381	7	MDA5	MDA5	NNP
cord-254895-ym0jsir5	381	8	is	be	VBZ
cord-254895-ym0jsir5	381	9	also	also	RB
cord-254895-ym0jsir5	381	10	a	a	DT
cord-254895-ym0jsir5	381	11	target	target	NN
cord-254895-ym0jsir5	381	12	of	of	IN
cord-254895-ym0jsir5	381	13	picornaviruses	picornavirus	NNS
cord-254895-ym0jsir5	381	14	since	since	IN
cord-254895-ym0jsir5	381	15	MDA5	MDA5	NNP
cord-254895-ym0jsir5	381	16	is	be	VBZ
cord-254895-ym0jsir5	381	17	degraded	degrade	VBN
cord-254895-ym0jsir5	381	18	in	in	IN
cord-254895-ym0jsir5	381	19	poliovirus	poliovirus	NN
cord-254895-ym0jsir5	381	20	-	-	HYPH
cord-254895-ym0jsir5	381	21	infected	infect	VBN
cord-254895-ym0jsir5	381	22	cells	cell	NNS
cord-254895-ym0jsir5	381	23	.	.	.
cord-254895-ym0jsir5	382	1	Interestingly	interestingly	RB
cord-254895-ym0jsir5	382	2	,	,	,
cord-254895-ym0jsir5	382	3	MDA5	MDA5	NNP
cord-254895-ym0jsir5	382	4	is	be	VBZ
cord-254895-ym0jsir5	382	5	not	not	RB
cord-254895-ym0jsir5	382	6	directly	directly	RB
cord-254895-ym0jsir5	382	7	cleaved	cleave	VBN
cord-254895-ym0jsir5	382	8	by	by	IN
cord-254895-ym0jsir5	382	9	virus	virus	NN
cord-254895-ym0jsir5	382	10	-	-	HYPH
cord-254895-ym0jsir5	382	11	encoded	encode	VBN
cord-254895-ym0jsir5	382	12	proteinases	proteinase	NNS
cord-254895-ym0jsir5	382	13	.	.	.
cord-254895-ym0jsir5	383	1	Degradation	degradation	NN
cord-254895-ym0jsir5	383	2	of	of	IN
cord-254895-ym0jsir5	383	3	MDA5	MDA5	NNP
cord-254895-ym0jsir5	383	4	in	in	IN
cord-254895-ym0jsir5	383	5	poliovirus	poliovirus	NN
cord-254895-ym0jsir5	383	6	-	-	HYPH
cord-254895-ym0jsir5	383	7	infected	infect	VBN
cord-254895-ym0jsir5	383	8	cells	cell	NNS
cord-254895-ym0jsir5	383	9	occurs	occur	VBZ
cord-254895-ym0jsir5	383	10	in	in	IN
cord-254895-ym0jsir5	383	11	a	a	DT
cord-254895-ym0jsir5	383	12	proteasome	proteasome	NN
cord-254895-ym0jsir5	383	13	-	-	HYPH
cord-254895-ym0jsir5	383	14	and	and	CC
cord-254895-ym0jsir5	383	15	caspase	caspase	NN
cord-254895-ym0jsir5	383	16	-	-	HYPH
cord-254895-ym0jsir5	383	17	dependent	dependent	JJ
cord-254895-ym0jsir5	383	18	manner	manner	NN
cord-254895-ym0jsir5	383	19	and	and	CC
cord-254895-ym0jsir5	383	20	correlates	correlate	VBZ
cord-254895-ym0jsir5	383	21	with	with	IN
cord-254895-ym0jsir5	383	22	the	the	DT
cord-254895-ym0jsir5	383	23	induction	induction	NN
cord-254895-ym0jsir5	383	24	of	of	IN
cord-254895-ym0jsir5	383	25	apoptosis	apoptosis	NN
cord-254895-ym0jsir5	383	26	in	in	IN
cord-254895-ym0jsir5	383	27	poliovirus	poliovirus	NN
cord-254895-ym0jsir5	383	28	-	-	HYPH
cord-254895-ym0jsir5	383	29	infected	infect	VBN
cord-254895-ym0jsir5	383	30	cells	cell	NNS
cord-254895-ym0jsir5	383	31	.	.	.
cord-254895-ym0jsir5	384	1	Poliovirus	Poliovirus	NNP
cord-254895-ym0jsir5	384	2	-	-	HYPH
cord-254895-ym0jsir5	384	3	induced	induce	VBN
cord-254895-ym0jsir5	384	4	MDA5	mda5	JJ
cord-254895-ym0jsir5	384	5	cleavage	cleavage	NN
cord-254895-ym0jsir5	384	6	attenuates	attenuate	VBZ
cord-254895-ym0jsir5	384	7	the	the	DT
cord-254895-ym0jsir5	384	8	production	production	NN
cord-254895-ym0jsir5	384	9	of	of	IN
cord-254895-ym0jsir5	384	10	type	type	NN
cord-254895-ym0jsir5	384	11	I	-PRON-	PRP
cord-254895-ym0jsir5	384	12	IFN	IFN	NNP
cord-254895-ym0jsir5	384	13	,	,	,
cord-254895-ym0jsir5	384	14	thereby	thereby	RB
cord-254895-ym0jsir5	384	15	allowing	allow	VBG
cord-254895-ym0jsir5	384	16	higher	high	JJR
cord-254895-ym0jsir5	384	17	levels	level	NNS
cord-254895-ym0jsir5	384	18	of	of	IN
cord-254895-ym0jsir5	384	19	viral	viral	JJ
cord-254895-ym0jsir5	384	20	replication	replication	NN
cord-254895-ym0jsir5	384	21	and	and	CC
cord-254895-ym0jsir5	384	22	dissemination	dissemination	NN
cord-254895-ym0jsir5	384	23	in	in	IN
cord-254895-ym0jsir5	384	24	the	the	DT
cord-254895-ym0jsir5	384	25	host	host	NN
cord-254895-ym0jsir5	384	26	(	(	-LRB-
cord-254895-ym0jsir5	384	27	Barral	Barral	NNP
cord-254895-ym0jsir5	384	28	et	et	FW
cord-254895-ym0jsir5	384	29	al	al	NNP
cord-254895-ym0jsir5	384	30	.	.	NNP
cord-254895-ym0jsir5	384	31	,	,	,
cord-254895-ym0jsir5	384	32	2007	2007	CD
cord-254895-ym0jsir5	384	33	)	)	-RRB-
cord-254895-ym0jsir5	384	34	.	.	.
cord-254895-ym0jsir5	385	1	Hepatitis	Hepatitis	NNP
cord-254895-ym0jsir5	385	2	C	C	NNP
cord-254895-ym0jsir5	385	3	virus	virus	NN
cord-254895-ym0jsir5	385	4	(	(	-LRB-
cord-254895-ym0jsir5	385	5	HCV	HCV	NNP
cord-254895-ym0jsir5	385	6	)	)	-RRB-
cord-254895-ym0jsir5	385	7	encodes	encode	VBZ
cord-254895-ym0jsir5	385	8	the	the	DT
cord-254895-ym0jsir5	385	9	protease	protease	NN
cord-254895-ym0jsir5	385	10	NS3/4A	ns3/4a	PRP
cord-254895-ym0jsir5	385	11	which	which	WDT
cord-254895-ym0jsir5	385	12	targets	target	VBZ
cord-254895-ym0jsir5	385	13	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	385	14	by	by	IN
cord-254895-ym0jsir5	385	15	cleaving	cleave	VBG
cord-254895-ym0jsir5	385	16	it	-PRON-	PRP
cord-254895-ym0jsir5	385	17	at	at	IN
cord-254895-ym0jsir5	385	18	position	position	NN
cord-254895-ym0jsir5	385	19	Cys-508	Cys-508	NNP
cord-254895-ym0jsir5	385	20	,	,	,
cord-254895-ym0jsir5	385	21	thereby	thereby	RB
cord-254895-ym0jsir5	385	22	dislocating	dislocate	VBG
cord-254895-ym0jsir5	385	23	it	-PRON-	PRP
cord-254895-ym0jsir5	385	24	from	from	IN
cord-254895-ym0jsir5	385	25	the	the	DT
cord-254895-ym0jsir5	385	26	mitochondrial	mitochondrial	JJ
cord-254895-ym0jsir5	385	27	membrane	membrane	NN
cord-254895-ym0jsir5	385	28	and	and	CC
cord-254895-ym0jsir5	385	29	thus	thus	RB
cord-254895-ym0jsir5	385	30	abrogating	abrogate	VBG
cord-254895-ym0jsir5	385	31	further	further	JJ
cord-254895-ym0jsir5	385	32	downstream	downstream	JJ
cord-254895-ym0jsir5	385	33	signaling	signal	VBG
cord-254895-ym0jsir5	385	34	to	to	IN
cord-254895-ym0jsir5	385	35	type	type	NN
cord-254895-ym0jsir5	385	36	I	-PRON-	PRP
cord-254895-ym0jsir5	385	37	IFN	IFN	NNP
cord-254895-ym0jsir5	385	38	and	and	CC
cord-254895-ym0jsir5	385	39	NFkB	nfkb	JJ
cord-254895-ym0jsir5	385	40	-	-	HYPH
cord-254895-ym0jsir5	385	41	dependent	dependent	JJ
cord-254895-ym0jsir5	385	42	target	target	NN
cord-254895-ym0jsir5	385	43	gene	gene	NN
cord-254895-ym0jsir5	385	44	expression	expression	NN
cord-254895-ym0jsir5	386	1	Meylan	Meylan	NNP
cord-254895-ym0jsir5	386	2	et	et	NNP
cord-254895-ym0jsir5	386	3	al	al	NNP
cord-254895-ym0jsir5	386	4	.	.	NNP
cord-254895-ym0jsir5	386	5	,	,	,
cord-254895-ym0jsir5	386	6	2005	2005	CD
cord-254895-ym0jsir5	386	7	)	)	-RRB-
cord-254895-ym0jsir5	386	8	.	.	.
cord-254895-ym0jsir5	387	1	Interestingly	interestingly	RB
cord-254895-ym0jsir5	387	2	,	,	,
cord-254895-ym0jsir5	387	3	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	387	4	was	be	VBD
cord-254895-ym0jsir5	387	5	also	also	RB
cord-254895-ym0jsir5	387	6	found	find	VBN
cord-254895-ym0jsir5	387	7	to	to	TO
cord-254895-ym0jsir5	387	8	be	be	VB
cord-254895-ym0jsir5	387	9	localized	localize	VBN
cord-254895-ym0jsir5	387	10	to	to	IN
cord-254895-ym0jsir5	387	11	the	the	DT
cord-254895-ym0jsir5	387	12	cytosol	cytosol	NN
cord-254895-ym0jsir5	387	13	and	and	CC
cord-254895-ym0jsir5	387	14	not	not	RB
cord-254895-ym0jsir5	387	15	the	the	DT
cord-254895-ym0jsir5	387	16	mitochondria	mitochondrion	NNS
cord-254895-ym0jsir5	387	17	in	in	IN
cord-254895-ym0jsir5	387	18	liver	liver	NN
cord-254895-ym0jsir5	387	19	tissue	tissue	NN
cord-254895-ym0jsir5	387	20	from	from	IN
cord-254895-ym0jsir5	387	21	patients	patient	NNS
cord-254895-ym0jsir5	387	22	chronically	chronically	RB
cord-254895-ym0jsir5	387	23	infected	infect	VBN
cord-254895-ym0jsir5	387	24	with	with	IN
cord-254895-ym0jsir5	387	25	HCV	HCV	NNP
cord-254895-ym0jsir5	387	26	(	(	-LRB-
cord-254895-ym0jsir5	387	27	Loo	Loo	NNP
cord-254895-ym0jsir5	387	28	et	et	FW
cord-254895-ym0jsir5	387	29	al	al	NNP
cord-254895-ym0jsir5	387	30	.	.	NNP
cord-254895-ym0jsir5	387	31	,	,	,
cord-254895-ym0jsir5	387	32	2006	2006	CD
cord-254895-ym0jsir5	387	33	)	)	-RRB-
cord-254895-ym0jsir5	387	34	.	.	.
cord-254895-ym0jsir5	388	1	Inhibitors	Inhibitors	NNP
cord-254895-ym0jsir5	388	2	of	of	IN
cord-254895-ym0jsir5	388	3	the	the	DT
cord-254895-ym0jsir5	388	4	HCV	HCV	NNP
cord-254895-ym0jsir5	388	5	NS3/4A	ns3/4a	NN
cord-254895-ym0jsir5	388	6	,	,	,
cord-254895-ym0jsir5	388	7	which	which	WDT
cord-254895-ym0jsir5	388	8	have	have	VBP
cord-254895-ym0jsir5	388	9	originally	originally	RB
cord-254895-ym0jsir5	388	10	been	be	VBN
cord-254895-ym0jsir5	388	11	designed	design	VBN
cord-254895-ym0jsir5	388	12	to	to	TO
cord-254895-ym0jsir5	388	13	inhibit	inhibit	VB
cord-254895-ym0jsir5	388	14	HCV	HCV	NNP
cord-254895-ym0jsir5	388	15	replication	replication	NN
cord-254895-ym0jsir5	388	16	,	,	,
cord-254895-ym0jsir5	388	17	are	be	VBP
cord-254895-ym0jsir5	388	18	able	able	JJ
cord-254895-ym0jsir5	388	19	to	to	TO
cord-254895-ym0jsir5	388	20	prevent	prevent	VB
cord-254895-ym0jsir5	388	21	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	388	22	cleavage	cleavage	NN
cord-254895-ym0jsir5	388	23	and	and	CC
cord-254895-ym0jsir5	388	24	restore	restore	VB
cord-254895-ym0jsir5	388	25	the	the	DT
cord-254895-ym0jsir5	388	26	RIG	rig	NN
cord-254895-ym0jsir5	388	27	-	-	HYPH
cord-254895-ym0jsir5	388	28	Imediated	imediate	VBN
cord-254895-ym0jsir5	388	29	innate	innate	JJ
cord-254895-ym0jsir5	388	30	immune	immune	JJ
cord-254895-ym0jsir5	388	31	response	response	NN
cord-254895-ym0jsir5	388	32	to	to	IN
cord-254895-ym0jsir5	388	33	HCV	HCV	NNP
cord-254895-ym0jsir5	388	34	.	.	.
cord-254895-ym0jsir5	389	1	Therefore	therefore	RB
cord-254895-ym0jsir5	389	2	,	,	,
cord-254895-ym0jsir5	389	3	NS3/4A	NS3/4A	NNP
cord-254895-ym0jsir5	389	4	inhibitors	inhibitor	NNS
cord-254895-ym0jsir5	389	5	which	which	WDT
cord-254895-ym0jsir5	389	6	are	be	VBP
cord-254895-ym0jsir5	389	7	already	already	RB
cord-254895-ym0jsir5	389	8	being	be	VBG
cord-254895-ym0jsir5	389	9	tested	test	VBN
cord-254895-ym0jsir5	389	10	in	in	IN
cord-254895-ym0jsir5	389	11	clinical	clinical	JJ
cord-254895-ym0jsir5	389	12	trials	trial	NNS
cord-254895-ym0jsir5	389	13	may	may	MD
cord-254895-ym0jsir5	389	14	have	have	VB
cord-254895-ym0jsir5	389	15	therapeutic	therapeutic	JJ
cord-254895-ym0jsir5	389	16	potential	potential	NN
cord-254895-ym0jsir5	389	17	for	for	IN
cord-254895-ym0jsir5	389	18	chronic	chronic	JJ
cord-254895-ym0jsir5	389	19	hepatitis	hepatitis	NN
cord-254895-ym0jsir5	389	20	C	c	NN
cord-254895-ym0jsir5	389	21	infection	infection	NN
cord-254895-ym0jsir5	389	22	.	.	.
cord-254895-ym0jsir5	390	1	The	the	DT
cord-254895-ym0jsir5	390	2	fact	fact	NN
cord-254895-ym0jsir5	390	3	that	that	IN
cord-254895-ym0jsir5	390	4	RNA	RNA	NNP
cord-254895-ym0jsir5	390	5	viruses	virus	NNS
cord-254895-ym0jsir5	390	6	have	have	VBP
cord-254895-ym0jsir5	390	7	developed	develop	VBN
cord-254895-ym0jsir5	390	8	so	so	RB
cord-254895-ym0jsir5	390	9	many	many	JJ
cord-254895-ym0jsir5	390	10	effective	effective	JJ
cord-254895-ym0jsir5	390	11	strategies	strategy	NNS
cord-254895-ym0jsir5	390	12	to	to	TO
cord-254895-ym0jsir5	390	13	interfere	interfere	VB
cord-254895-ym0jsir5	390	14	with	with	IN
cord-254895-ym0jsir5	390	15	the	the	DT
cord-254895-ym0jsir5	390	16	RNA	RNA	NNP
cord-254895-ym0jsir5	390	17	helicase	helicase	NN
cord-254895-ym0jsir5	390	18	pathway	pathway	NN
cord-254895-ym0jsir5	390	19	of	of	IN
cord-254895-ym0jsir5	390	20	viral	viral	JJ
cord-254895-ym0jsir5	390	21	recognition	recognition	NN
cord-254895-ym0jsir5	390	22	during	during	IN
cord-254895-ym0jsir5	390	23	coevolution	coevolution	NN
cord-254895-ym0jsir5	390	24	with	with	IN
cord-254895-ym0jsir5	390	25	their	-PRON-	PRP$
cord-254895-ym0jsir5	390	26	host	host	NN
cord-254895-ym0jsir5	390	27	provides	provide	VBZ
cord-254895-ym0jsir5	390	28	further	further	JJ
cord-254895-ym0jsir5	390	29	proof	proof	NN
cord-254895-ym0jsir5	390	30	for	for	IN
cord-254895-ym0jsir5	390	31	the	the	DT
cord-254895-ym0jsir5	390	32	central	central	JJ
cord-254895-ym0jsir5	390	33	role	role	NN
cord-254895-ym0jsir5	390	34	of	of	IN
cord-254895-ym0jsir5	390	35	this	this	DT
cord-254895-ym0jsir5	390	36	pathway	pathway	NN
cord-254895-ym0jsir5	390	37	in	in	IN
cord-254895-ym0jsir5	390	38	antiviral	antiviral	JJ
cord-254895-ym0jsir5	390	39	immune	immune	JJ
cord-254895-ym0jsir5	390	40	defense	defense	NN
cord-254895-ym0jsir5	390	41	.	.	.
cord-254895-ym0jsir5	391	1	Involvement	involvement	NN
cord-254895-ym0jsir5	391	2	of	of	IN
cord-254895-ym0jsir5	391	3	the	the	DT
cord-254895-ym0jsir5	391	4	Toll	Toll	NNP
cord-254895-ym0jsir5	391	5	-	-	HYPH
cord-254895-ym0jsir5	391	6	like	like	JJ
cord-254895-ym0jsir5	391	7	receptor	receptor	NN
cord-254895-ym0jsir5	391	8	9	9	CD
cord-254895-ym0jsir5	391	9	signaling	signal	VBG
cord-254895-ym0jsir5	391	10	pathway	pathway	NN
cord-254895-ym0jsir5	391	11	in	in	IN
cord-254895-ym0jsir5	391	12	the	the	DT
cord-254895-ym0jsir5	391	13	induction	induction	NN
cord-254895-ym0jsir5	391	14	of	of	IN
cord-254895-ym0jsir5	391	15	innate	innate	JJ
cord-254895-ym0jsir5	391	16	immunity	immunity	NN
cord-254895-ym0jsir5	391	17	by	by	IN
cord-254895-ym0jsir5	391	18	baculovirus	baculovirus	NNP
cord-254895-ym0jsir5	391	19	Recognition	Recognition	NNP
cord-254895-ym0jsir5	391	20	of	of	IN
cord-254895-ym0jsir5	391	21	double	double	RB
cord-254895-ym0jsir5	391	22	-	-	HYPH
cord-254895-ym0jsir5	391	23	stranded	strand	VBN
cord-254895-ym0jsir5	391	24	RNA	RNA	NNP
cord-254895-ym0jsir5	391	25	and	and	CC
cord-254895-ym0jsir5	391	26	activation	activation	NN
cord-254895-ym0jsir5	391	27	of	of	IN
cord-254895-ym0jsir5	391	28	NF	NF	NNP
cord-254895-ym0jsir5	391	29	-	-	HYPH
cord-254895-ym0jsir5	391	30	kappaB	kappaB	NNP
cord-254895-ym0jsir5	391	31	by	by	IN
cord-254895-ym0jsir5	391	32	Toll	Toll	NNP
cord-254895-ym0jsir5	391	33	-	-	HYPH
cord-254895-ym0jsir5	391	34	like	like	JJ
cord-254895-ym0jsir5	391	35	receptor	receptor	NN
cord-254895-ym0jsir5	391	36	3	3	CD
cord-254895-ym0jsir5	392	1	The	the	DT
cord-254895-ym0jsir5	392	2	pathogenic	pathogenic	JJ
cord-254895-ym0jsir5	392	3	NY-1	NY-1	NNP
cord-254895-ym0jsir5	392	4	hantavirus	hantavirus	NN
cord-254895-ym0jsir5	392	5	G1	G1	NNP
cord-254895-ym0jsir5	392	6	cytoplasmic	cytoplasmic	JJ
cord-254895-ym0jsir5	392	7	tail	tail	NN
cord-254895-ym0jsir5	392	8	inhibits	inhibit	VBZ
cord-254895-ym0jsir5	392	9	RIG	rig	NN
cord-254895-ym0jsir5	392	10	-	-	HYPH
cord-254895-ym0jsir5	392	11	I	i	NN
cord-254895-ym0jsir5	392	12	-	-	HYPH
cord-254895-ym0jsir5	392	13	and	and	CC
cord-254895-ym0jsir5	392	14	TBK-1-directed	tbk-1-directe	VBD
cord-254895-ym0jsir5	392	15	interferon	interferon	NN
cord-254895-ym0jsir5	392	16	responses	response	VBZ
cord-254895-ym0jsir5	392	17	Interaction	Interaction	NNP
cord-254895-ym0jsir5	392	18	between	between	IN
cord-254895-ym0jsir5	392	19	conventional	conventional	JJ
cord-254895-ym0jsir5	392	20	dendritic	dendritic	JJ
cord-254895-ym0jsir5	392	21	cells	cell	NNS
cord-254895-ym0jsir5	392	22	and	and	CC
cord-254895-ym0jsir5	392	23	natural	natural	JJ
cord-254895-ym0jsir5	392	24	killer	killer	NN
cord-254895-ym0jsir5	392	25	cells	cell	NNS
cord-254895-ym0jsir5	392	26	is	be	VBZ
cord-254895-ym0jsir5	392	27	integral	integral	JJ
cord-254895-ym0jsir5	392	28	to	to	IN
cord-254895-ym0jsir5	392	29	the	the	DT
cord-254895-ym0jsir5	392	30	activation	activation	NN
cord-254895-ym0jsir5	392	31	of	of	IN
cord-254895-ym0jsir5	392	32	effective	effective	JJ
cord-254895-ym0jsir5	392	33	antiviral	antiviral	JJ
cord-254895-ym0jsir5	392	34	immunity	immunity	NN
cord-254895-ym0jsir5	393	1	The	the	DT
cord-254895-ym0jsir5	393	2	V	v	NN
cord-254895-ym0jsir5	393	3	proteins	protein	NNS
cord-254895-ym0jsir5	393	4	of	of	IN
cord-254895-ym0jsir5	393	5	paramyxoviruses	paramyxovirus	NNS
cord-254895-ym0jsir5	393	6	bind	bind	VBP
cord-254895-ym0jsir5	393	7	the	the	DT
cord-254895-ym0jsir5	393	8	IFN	IFN	NNP
cord-254895-ym0jsir5	393	9	-	-	HYPH
cord-254895-ym0jsir5	393	10	inducible	inducible	JJ
cord-254895-ym0jsir5	393	11	RNA	RNA	NNP
cord-254895-ym0jsir5	393	12	helicase	helicase	NN
cord-254895-ym0jsir5	393	13	,	,	,
cord-254895-ym0jsir5	393	14	mda-5	mda-5	NNP
cord-254895-ym0jsir5	393	15	,	,	,
cord-254895-ym0jsir5	393	16	and	and	CC
cord-254895-ym0jsir5	393	17	inhibit	inhibit	VB
cord-254895-ym0jsir5	393	18	its	-PRON-	PRP$
cord-254895-ym0jsir5	393	19	activation	activation	NN
cord-254895-ym0jsir5	393	20	of	of	IN
cord-254895-ym0jsir5	393	21	the	the	DT
cord-254895-ym0jsir5	393	22	IFN	IFN	NNP
cord-254895-ym0jsir5	393	23	-	-	HYPH
cord-254895-ym0jsir5	393	24	beta	beta	NN
cord-254895-ym0jsir5	393	25	promoter	promoter	NN
cord-254895-ym0jsir5	393	26	A	a	DT
cord-254895-ym0jsir5	393	27	FADDdependent	fadddependent	NN
cord-254895-ym0jsir5	393	28	innate	innate	JJ
cord-254895-ym0jsir5	393	29	immune	immune	JJ
cord-254895-ym0jsir5	393	30	mechanism	mechanism	NN
cord-254895-ym0jsir5	393	31	in	in	IN
cord-254895-ym0jsir5	393	32	mammalian	mammalian	JJ
cord-254895-ym0jsir5	393	33	cells	cell	NNS
cord-254895-ym0jsir5	393	34	Dendritic	dendritic	JJ
cord-254895-ym0jsir5	393	35	cells	cell	NNS
cord-254895-ym0jsir5	393	36	respond	respond	VBP
cord-254895-ym0jsir5	393	37	to	to	IN
cord-254895-ym0jsir5	393	38	influenza	influenza	NN
cord-254895-ym0jsir5	393	39	virus	virus	NN
cord-254895-ym0jsir5	393	40	through	through	IN
cord-254895-ym0jsir5	393	41	TLR7-and	TLR7-and	NNP
cord-254895-ym0jsir5	393	42	PKRindependent	PKRindependent	NNP
cord-254895-ym0jsir5	393	43	pathways	pathway	NNS
cord-254895-ym0jsir5	394	1	MDA-5	MDA-5	NNP
cord-254895-ym0jsir5	394	2	is	be	VBZ
cord-254895-ym0jsir5	394	3	cleaved	cleave	VBN
cord-254895-ym0jsir5	394	4	in	in	IN
cord-254895-ym0jsir5	394	5	poliovirus	poliovirus	NN
cord-254895-ym0jsir5	394	6	-	-	HYPH
cord-254895-ym0jsir5	394	7	infected	infect	VBN
cord-254895-ym0jsir5	394	8	cells	cell	NNS
cord-254895-ym0jsir5	394	9	Adenovirus	Adenovirus	NNP
cord-254895-ym0jsir5	394	10	efficiently	efficiently	RB
cord-254895-ym0jsir5	394	11	transduces	transduce	VBZ
cord-254895-ym0jsir5	394	12	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	394	13	dendritic	dendritic	JJ
cord-254895-ym0jsir5	394	14	cells	cell	NNS
cord-254895-ym0jsir5	394	15	resulting	result	VBG
cord-254895-ym0jsir5	394	16	in	in	IN
cord-254895-ym0jsir5	394	17	TLR9-dependent	TLR9-dependent	NNP
cord-254895-ym0jsir5	394	18	maturation	maturation	NN
cord-254895-ym0jsir5	394	19	and	and	CC
cord-254895-ym0jsir5	394	20	IFNalpha	ifnalpha	NN
cord-254895-ym0jsir5	394	21	production	production	NN
cord-254895-ym0jsir5	394	22	Endocytosis	Endocytosis	NNP
cord-254895-ym0jsir5	394	23	of	of	IN
cord-254895-ym0jsir5	394	24	HIV-1	HIV-1	NNP
cord-254895-ym0jsir5	395	1	activates	activate	VBZ
cord-254895-ym0jsir5	395	2	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	395	3	dendritic	dendritic	JJ
cord-254895-ym0jsir5	395	4	cells	cell	NNS
cord-254895-ym0jsir5	395	5	via	via	IN
cord-254895-ym0jsir5	395	6	Toll	toll	NN
cord-254895-ym0jsir5	395	7	-	-	HYPH
cord-254895-ym0jsir5	395	8	like	like	JJ
cord-254895-ym0jsir5	395	9	receptor	receptor	NN
cord-254895-ym0jsir5	395	10	-	-	HYPH
cord-254895-ym0jsir5	395	11	viral	viral	JJ
cord-254895-ym0jsir5	395	12	RNA	RNA	NNP
cord-254895-ym0jsir5	395	13	interactions	interaction	NNS
cord-254895-ym0jsir5	395	14	Cutting	cut	VBG
cord-254895-ym0jsir5	395	15	edge	edge	NN
cord-254895-ym0jsir5	395	16	:	:	:
cord-254895-ym0jsir5	395	17	conventional	conventional	JJ
cord-254895-ym0jsir5	395	18	CD8	CD8	NNS
cord-254895-ym0jsir5	395	19	alpha+	alpha+	DT
cord-254895-ym0jsir5	395	20	dendritic	dendritic	JJ
cord-254895-ym0jsir5	395	21	cells	cell	NNS
cord-254895-ym0jsir5	395	22	are	be	VBP
cord-254895-ym0jsir5	395	23	generally	generally	RB
cord-254895-ym0jsir5	395	24	involved	involve	VBN
cord-254895-ym0jsir5	395	25	in	in	IN
cord-254895-ym0jsir5	395	26	priming	prime	VBG
cord-254895-ym0jsir5	395	27	CTL	ctl	NN
cord-254895-ym0jsir5	395	28	immunity	immunity	NN
cord-254895-ym0jsir5	395	29	to	to	IN
cord-254895-ym0jsir5	395	30	viruses	virus	NNS
cord-254895-ym0jsir5	396	1	The	the	DT
cord-254895-ym0jsir5	396	2	interferoninducible	interferoninducible	JJ
cord-254895-ym0jsir5	396	3	RNA	RNA	NNP
cord-254895-ym0jsir5	396	4	helicase	helicase	NN
cord-254895-ym0jsir5	396	5	,	,	,
cord-254895-ym0jsir5	396	6	mda-5	mda-5	NNP
cord-254895-ym0jsir5	396	7	,	,	,
cord-254895-ym0jsir5	396	8	is	be	VBZ
cord-254895-ym0jsir5	396	9	involved	involve	VBN
cord-254895-ym0jsir5	396	10	in	in	IN
cord-254895-ym0jsir5	396	11	measles	measles	NN
cord-254895-ym0jsir5	396	12	virus	virus	NN
cord-254895-ym0jsir5	396	13	-	-	HYPH
cord-254895-ym0jsir5	396	14	induced	induce	VBN
cord-254895-ym0jsir5	396	15	expression	expression	NN
cord-254895-ym0jsir5	396	16	of	of	IN
cord-254895-ym0jsir5	396	17	antiviral	antiviral	JJ
cord-254895-ym0jsir5	396	18	cytokines	cytokine	NNS
cord-254895-ym0jsir5	396	19	Flexibility	Flexibility	NNP
cord-254895-ym0jsir5	396	20	of	of	IN
cord-254895-ym0jsir5	396	21	mouse	mouse	NN
cord-254895-ym0jsir5	396	22	classical	classical	JJ
cord-254895-ym0jsir5	396	23	and	and	CC
cord-254895-ym0jsir5	396	24	plasmacytoid	plasmacytoid	JJ
cord-254895-ym0jsir5	396	25	-	-	HYPH
cord-254895-ym0jsir5	396	26	derived	derive	VBN
cord-254895-ym0jsir5	396	27	dendritic	dendritic	JJ
cord-254895-ym0jsir5	396	28	cells	cell	NNS
cord-254895-ym0jsir5	396	29	in	in	IN
cord-254895-ym0jsir5	396	30	directing	direct	VBG
cord-254895-ym0jsir5	396	31	T	T	NNP
cord-254895-ym0jsir5	396	32	helper	helper	NN
cord-254895-ym0jsir5	396	33	type	type	NN
cord-254895-ym0jsir5	396	34	1	1	CD
cord-254895-ym0jsir5	396	35	and	and	CC
cord-254895-ym0jsir5	396	36	2	2	CD
cord-254895-ym0jsir5	396	37	cell	cell	NN
cord-254895-ym0jsir5	396	38	development	development	NN
cord-254895-ym0jsir5	396	39	:	:	:
cord-254895-ym0jsir5	396	40	dependency	dependency	NN
cord-254895-ym0jsir5	396	41	on	on	IN
cord-254895-ym0jsir5	396	42	antigen	antigen	NN
cord-254895-ym0jsir5	396	43	dose	dose	NN
cord-254895-ym0jsir5	396	44	and	and	CC
cord-254895-ym0jsir5	396	45	differential	differential	JJ
cord-254895-ym0jsir5	396	46	toll	toll	NN
cord-254895-ym0jsir5	396	47	-	-	HYPH
cord-254895-ym0jsir5	396	48	like	like	JJ
cord-254895-ym0jsir5	396	49	receptor	receptor	NN
cord-254895-ym0jsir5	396	50	ligation	ligation	NN
cord-254895-ym0jsir5	396	51	Nonstructural	nonstructural	JJ
cord-254895-ym0jsir5	396	52	proteins	protein	NNS
cord-254895-ym0jsir5	396	53	NS1	NS1	NNS
cord-254895-ym0jsir5	396	54	and	and	CC
cord-254895-ym0jsir5	396	55	NS2	ns2	NN
cord-254895-ym0jsir5	396	56	of	of	IN
cord-254895-ym0jsir5	396	57	bovine	bovine	JJ
cord-254895-ym0jsir5	396	58	respiratory	respiratory	JJ
cord-254895-ym0jsir5	396	59	syncytial	syncytial	JJ
cord-254895-ym0jsir5	396	60	virus	virus	NN
cord-254895-ym0jsir5	396	61	block	block	NN
cord-254895-ym0jsir5	396	62	activation	activation	NN
cord-254895-ym0jsir5	396	63	of	of	IN
cord-254895-ym0jsir5	396	64	interferon	interferon	NN
cord-254895-ym0jsir5	396	65	regulatory	regulatory	JJ
cord-254895-ym0jsir5	396	66	factor	factor	NN
cord-254895-ym0jsir5	396	67	3	3	CD
cord-254895-ym0jsir5	396	68	Identification	Identification	NNP
cord-254895-ym0jsir5	396	69	of	of	IN
cord-254895-ym0jsir5	396	70	the	the	DT
cord-254895-ym0jsir5	396	71	rabies	rabies	NN
cord-254895-ym0jsir5	396	72	virus	virus	NN
cord-254895-ym0jsir5	396	73	alpha	alpha	NN
cord-254895-ym0jsir5	396	74	/	/	SYM
cord-254895-ym0jsir5	396	75	beta	beta	NN
cord-254895-ym0jsir5	396	76	interferon	interferon	NN
cord-254895-ym0jsir5	396	77	antagonist	antagonist	NN
cord-254895-ym0jsir5	396	78	:	:	:
cord-254895-ym0jsir5	396	79	phosphoprotein	phosphoprotein	NN
cord-254895-ym0jsir5	396	80	P	p	NN
cord-254895-ym0jsir5	396	81	interferes	interfere	VBZ
cord-254895-ym0jsir5	396	82	with	with	IN
cord-254895-ym0jsir5	396	83	phosphorylation	phosphorylation	NN
cord-254895-ym0jsir5	396	84	of	of	IN
cord-254895-ym0jsir5	396	85	interferon	interferon	NN
cord-254895-ym0jsir5	396	86	regulatory	regulatory	JJ
cord-254895-ym0jsir5	396	87	factor	factor	NN
cord-254895-ym0jsir5	396	88	3	3	CD
cord-254895-ym0jsir5	396	89	Herpes	Herpes	NNP
cord-254895-ym0jsir5	396	90	simplex	simplex	NN
cord-254895-ym0jsir5	396	91	virus	virus	NN
cord-254895-ym0jsir5	396	92	encephalitis	encephalitis	RB
cord-254895-ym0jsir5	396	93	in	in	IN
cord-254895-ym0jsir5	396	94	human	human	JJ
cord-254895-ym0jsir5	396	95	UNC-93B	unc-93b	NN
cord-254895-ym0jsir5	396	96	deficiency	deficiency	NN
cord-254895-ym0jsir5	397	1	Plasmacytoid	Plasmacytoid	NNP
cord-254895-ym0jsir5	397	2	monocytes	monocyte	NNS
cord-254895-ym0jsir5	397	3	migrate	migrate	VBP
cord-254895-ym0jsir5	397	4	to	to	IN
cord-254895-ym0jsir5	397	5	inflamed	inflamed	JJ
cord-254895-ym0jsir5	397	6	lymph	lymph	NN
cord-254895-ym0jsir5	397	7	nodes	node	NNS
cord-254895-ym0jsir5	397	8	and	and	CC
cord-254895-ym0jsir5	397	9	produce	produce	VB
cord-254895-ym0jsir5	397	10	large	large	JJ
cord-254895-ym0jsir5	397	11	amounts	amount	NNS
cord-254895-ym0jsir5	397	12	of	of	IN
cord-254895-ym0jsir5	397	13	type	type	NN
cord-254895-ym0jsir5	398	1	I	-PRON-	PRP
cord-254895-ym0jsir5	398	2	interferon	interferon	VBD
cord-254895-ym0jsir5	398	3	Control	Control	NNP
cord-254895-ym0jsir5	398	4	of	of	IN
cord-254895-ym0jsir5	398	5	coronavirus	coronavirus	NN
cord-254895-ym0jsir5	398	6	infection	infection	NN
cord-254895-ym0jsir5	398	7	through	through	IN
cord-254895-ym0jsir5	398	8	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	398	9	dendritic	dendritic	JJ
cord-254895-ym0jsir5	398	10	cell	cell	NN
cord-254895-ym0jsir5	398	11	-	-	HYPH
cord-254895-ym0jsir5	398	12	derived	derive	VBN
cord-254895-ym0jsir5	398	13	type	type	NN
cord-254895-ym0jsir5	399	1	I	-PRON-	PRP
cord-254895-ym0jsir5	399	2	interferon	interferon	RB
cord-254895-ym0jsir5	399	3	MDA-5	MDA-5	NNP
cord-254895-ym0jsir5	399	4	,	,	,
cord-254895-ym0jsir5	399	5	but	but	CC
cord-254895-ym0jsir5	400	1	not	not	RB
cord-254895-ym0jsir5	400	2	RIG	rig	NN
cord-254895-ym0jsir5	400	3	-	-	:
cord-254895-ym0jsir5	400	4	I	I	NNP
cord-254895-ym0jsir5	400	5	,	,	,
cord-254895-ym0jsir5	400	6	is	be	VBZ
cord-254895-ym0jsir5	400	7	a	a	DT
cord-254895-ym0jsir5	400	8	common	common	JJ
cord-254895-ym0jsir5	400	9	target	target	NN
cord-254895-ym0jsir5	400	10	for	for	IN
cord-254895-ym0jsir5	400	11	paramyxovirus	paramyxovirus	JJ
cord-254895-ym0jsir5	400	12	V	V	NNP
cord-254895-ym0jsir5	400	13	proteins	protein	NNS
cord-254895-ym0jsir5	400	14	Interferon	Interferon	NNP
cord-254895-ym0jsir5	400	15	-	-	HYPH
cord-254895-ym0jsir5	400	16	producing	produce	VBG
cord-254895-ym0jsir5	400	17	cells	cell	NNS
cord-254895-ym0jsir5	400	18	:	:	:
cord-254895-ym0jsir5	400	19	on	on	IN
cord-254895-ym0jsir5	400	20	the	the	DT
cord-254895-ym0jsir5	400	21	front	front	JJ
cord-254895-ym0jsir5	400	22	line	line	NN
cord-254895-ym0jsir5	400	23	in	in	IN
cord-254895-ym0jsir5	400	24	immune	immune	JJ
cord-254895-ym0jsir5	400	25	responses	response	NNS
cord-254895-ym0jsir5	400	26	against	against	IN
cord-254895-ym0jsir5	400	27	pathogens	pathogen	NNS
cord-254895-ym0jsir5	401	1	Interferon	interferon	NN
cord-254895-ym0jsir5	401	2	alpha	alpha	NN
cord-254895-ym0jsir5	401	3	/	/	SYM
cord-254895-ym0jsir5	401	4	beta	beta	NN
cord-254895-ym0jsir5	401	5	and	and	CC
cord-254895-ym0jsir5	401	6	interleukin	interleukin	NN
cord-254895-ym0jsir5	401	7	12	12	CD
cord-254895-ym0jsir5	401	8	responses	response	NNS
cord-254895-ym0jsir5	401	9	to	to	IN
cord-254895-ym0jsir5	401	10	viral	viral	JJ
cord-254895-ym0jsir5	401	11	infections	infection	NNS
cord-254895-ym0jsir5	401	12	:	:	:
cord-254895-ym0jsir5	401	13	pathways	pathway	NNS
cord-254895-ym0jsir5	401	14	regulating	regulate	VBG
cord-254895-ym0jsir5	401	15	dendritic	dendritic	JJ
cord-254895-ym0jsir5	401	16	cell	cell	NN
cord-254895-ym0jsir5	401	17	cytokine	cytokine	NN
cord-254895-ym0jsir5	401	18	expression	expression	NN
cord-254895-ym0jsir5	401	19	in	in	IN
cord-254895-ym0jsir5	401	20	vivo	vivo	NNP
cord-254895-ym0jsir5	401	21	Dendritic	dendritic	JJ
cord-254895-ym0jsir5	401	22	cell	cell	NN
cord-254895-ym0jsir5	401	23	responses	response	NNS
cord-254895-ym0jsir5	401	24	to	to	IN
cord-254895-ym0jsir5	401	25	early	early	JJ
cord-254895-ym0jsir5	401	26	murine	murine	JJ
cord-254895-ym0jsir5	401	27	cytomegalovirus	cytomegalovirus	JJ
cord-254895-ym0jsir5	401	28	infection	infection	NN
cord-254895-ym0jsir5	401	29	:	:	:
cord-254895-ym0jsir5	401	30	subset	subset	VBN
cord-254895-ym0jsir5	401	31	functional	functional	JJ
cord-254895-ym0jsir5	401	32	specialization	specialization	NN
cord-254895-ym0jsir5	401	33	and	and	CC
cord-254895-ym0jsir5	401	34	differential	differential	JJ
cord-254895-ym0jsir5	401	35	regulation	regulation	NN
cord-254895-ym0jsir5	401	36	by	by	IN
cord-254895-ym0jsir5	401	37	interferon	interferon	NN
cord-254895-ym0jsir5	401	38	alpha	alpha	NN
cord-254895-ym0jsir5	401	39	/	/	SYM
cord-254895-ym0jsir5	401	40	beta	beta	NN
cord-254895-ym0jsir5	401	41	MyD88-dependent	MyD88-dependent	NNP
cord-254895-ym0jsir5	401	42	and	and	CC
cord-254895-ym0jsir5	401	43	-independent	-independent	JJ
cord-254895-ym0jsir5	401	44	murine	murine	JJ
cord-254895-ym0jsir5	401	45	cytomegalovirus	cytomegalovirus	NN
cord-254895-ym0jsir5	401	46	sensing	sensing	NN
cord-254895-ym0jsir5	401	47	for	for	IN
cord-254895-ym0jsir5	401	48	IFN	IFN	NNP
cord-254895-ym0jsir5	401	49	-	-	HYPH
cord-254895-ym0jsir5	401	50	alpha	alpha	NN
cord-254895-ym0jsir5	401	51	release	release	NN
cord-254895-ym0jsir5	401	52	and	and	CC
cord-254895-ym0jsir5	401	53	initiation	initiation	NN
cord-254895-ym0jsir5	401	54	of	of	IN
cord-254895-ym0jsir5	401	55	immune	immune	JJ
cord-254895-ym0jsir5	401	56	responses	response	NNS
cord-254895-ym0jsir5	401	57	in	in	IN
cord-254895-ym0jsir5	401	58	vivo	vivo	NN
cord-254895-ym0jsir5	401	59	Viral	viral	JJ
cord-254895-ym0jsir5	401	60	infection	infection	NN
cord-254895-ym0jsir5	401	61	switches	switch	VBZ
cord-254895-ym0jsir5	401	62	non	non	JJ
cord-254895-ym0jsir5	401	63	-	-	JJ
cord-254895-ym0jsir5	401	64	plasmacytoid	plasmacytoid	JJ
cord-254895-ym0jsir5	401	65	dendritic	dendritic	JJ
cord-254895-ym0jsir5	401	66	cells	cell	NNS
cord-254895-ym0jsir5	401	67	into	into	IN
cord-254895-ym0jsir5	401	68	high	high	JJ
cord-254895-ym0jsir5	401	69	interferon	interferon	NN
cord-254895-ym0jsir5	401	70	producers	producer	NNS
cord-254895-ym0jsir5	401	71	Innate	innate	VBP
cord-254895-ym0jsir5	401	72	antiviral	antiviral	JJ
cord-254895-ym0jsir5	401	73	responses	response	NNS
cord-254895-ym0jsir5	401	74	by	by	IN
cord-254895-ym0jsir5	401	75	means	mean	NNS
cord-254895-ym0jsir5	401	76	of	of	IN
cord-254895-ym0jsir5	401	77	TLR7-mediated	tlr7-mediated	JJ
cord-254895-ym0jsir5	401	78	recognition	recognition	NN
cord-254895-ym0jsir5	401	79	of	of	IN
cord-254895-ym0jsir5	401	80	single	single	RB
cord-254895-ym0jsir5	401	81	-	-	HYPH
cord-254895-ym0jsir5	401	82	stranded	strand	VBN
cord-254895-ym0jsir5	401	83	RNA	rna	NN
cord-254895-ym0jsir5	401	84	Does	do	VBZ
cord-254895-ym0jsir5	401	85	Toll	Toll	NNP
cord-254895-ym0jsir5	401	86	-	-	HYPH
cord-254895-ym0jsir5	401	87	like	like	JJ
cord-254895-ym0jsir5	401	88	receptor	receptor	NN
cord-254895-ym0jsir5	401	89	3	3	CD
cord-254895-ym0jsir5	401	90	play	play	VBP
cord-254895-ym0jsir5	401	91	a	a	DT
cord-254895-ym0jsir5	401	92	biological	biological	JJ
cord-254895-ym0jsir5	401	93	role	role	NN
cord-254895-ym0jsir5	401	94	in	in	IN
cord-254895-ym0jsir5	401	95	virus	virus	NN
cord-254895-ym0jsir5	401	96	infections	infection	NNS
cord-254895-ym0jsir5	401	97	?	?	.
cord-254895-ym0jsir5	402	1	Toll	toll	NN
cord-254895-ym0jsir5	402	2	-	-	HYPH
cord-254895-ym0jsir5	402	3	like	like	JJ
cord-254895-ym0jsir5	402	4	receptor	receptor	NN
cord-254895-ym0jsir5	402	5	expression	expression	NN
cord-254895-ym0jsir5	402	6	in	in	IN
cord-254895-ym0jsir5	402	7	murine	murine	JJ
cord-254895-ym0jsir5	402	8	DC	DC	NNP
cord-254895-ym0jsir5	402	9	subsets	subset	NNS
cord-254895-ym0jsir5	402	10	:	:	:
cord-254895-ym0jsir5	403	1	lack	lack	NN
cord-254895-ym0jsir5	403	2	of	of	IN
cord-254895-ym0jsir5	403	3	TLR7	TLR7	NNP
cord-254895-ym0jsir5	403	4	expression	expression	NN
cord-254895-ym0jsir5	403	5	by	by	IN
cord-254895-ym0jsir5	403	6	CD8	CD8	NNP
cord-254895-ym0jsir5	403	7	alpha+	alpha+	NNP
cord-254895-ym0jsir5	403	8	DC	DC	NNP
cord-254895-ym0jsir5	403	9	correlates	correlate	VBZ
cord-254895-ym0jsir5	403	10	with	with	IN
cord-254895-ym0jsir5	403	11	unresponsiveness	unresponsiveness	NN
cord-254895-ym0jsir5	403	12	to	to	IN
cord-254895-ym0jsir5	403	13	imidazoquinolines	imidazoquinolines	NNP
cord-254895-ym0jsir5	403	14	IKKepsilon	IKKepsilon	NNP
cord-254895-ym0jsir5	403	15	and	and	CC
cord-254895-ym0jsir5	403	16	TBK1	TBK1	NNP
cord-254895-ym0jsir5	404	1	are	be	VBP
cord-254895-ym0jsir5	404	2	essential	essential	JJ
cord-254895-ym0jsir5	404	3	components	component	NNS
cord-254895-ym0jsir5	404	4	of	of	IN
cord-254895-ym0jsir5	404	5	the	the	DT
cord-254895-ym0jsir5	404	6	IRF3	IRF3	NNP
cord-254895-ym0jsir5	404	7	signaling	signal	VBG
cord-254895-ym0jsir5	404	8	pathway	pathway	NN
cord-254895-ym0jsir5	404	9	Identification	identification	NN
cord-254895-ym0jsir5	404	10	and	and	CC
cord-254895-ym0jsir5	404	11	characterization	characterization	NN
cord-254895-ym0jsir5	404	12	of	of	IN
cord-254895-ym0jsir5	404	13	viral	viral	JJ
cord-254895-ym0jsir5	404	14	antagonists	antagonist	NNS
cord-254895-ym0jsir5	404	15	of	of	IN
cord-254895-ym0jsir5	404	16	type	type	NN
cord-254895-ym0jsir5	404	17	I	-PRON-	PRP
cord-254895-ym0jsir5	404	18	interferon	interferon	VBD
cord-254895-ym0jsir5	404	19	in	in	IN
cord-254895-ym0jsir5	404	20	negative	negative	JJ
cord-254895-ym0jsir5	404	21	-	-	HYPH
cord-254895-ym0jsir5	404	22	strand	strand	NN
cord-254895-ym0jsir5	404	23	RNA	RNA	NNP
cord-254895-ym0jsir5	404	24	viruses	virus	NNS
cord-254895-ym0jsir5	405	1	Influenza	Influenza	NNP
cord-254895-ym0jsir5	405	2	A	a	DT
cord-254895-ym0jsir5	405	3	virus	virus	NN
cord-254895-ym0jsir5	405	4	lacking	lack	VBG
cord-254895-ym0jsir5	406	1	the	the	DT
cord-254895-ym0jsir5	406	2	NS1	NS1	NNP
cord-254895-ym0jsir5	406	3	gene	gene	NN
cord-254895-ym0jsir5	406	4	replicates	replicate	NNS
cord-254895-ym0jsir5	406	5	in	in	IN
cord-254895-ym0jsir5	406	6	interferondeficient	interferondeficient	NN
cord-254895-ym0jsir5	406	7	systems	system	NNS
cord-254895-ym0jsir5	406	8	Essential	essential	JJ
cord-254895-ym0jsir5	406	9	role	role	NN
cord-254895-ym0jsir5	406	10	of	of	IN
cord-254895-ym0jsir5	406	11	mda-5	mda-5	DT
cord-254895-ym0jsir5	406	12	in	in	IN
cord-254895-ym0jsir5	406	13	type	type	NN
cord-254895-ym0jsir5	406	14	I	-PRON-	PRP
cord-254895-ym0jsir5	406	15	IFN	IFN	NNP
cord-254895-ym0jsir5	406	16	responses	response	NNS
cord-254895-ym0jsir5	406	17	to	to	IN
cord-254895-ym0jsir5	406	18	polyriboinosinic	polyriboinosinic	NNP
cord-254895-ym0jsir5	406	19	:	:	:
cord-254895-ym0jsir5	406	20	polyribocytidylic	polyribocytidylic	JJ
cord-254895-ym0jsir5	406	21	acid	acid	NN
cord-254895-ym0jsir5	406	22	and	and	CC
cord-254895-ym0jsir5	406	23	encephalomyocarditis	encephalomyocarditis	NNP
cord-254895-ym0jsir5	406	24	picornavirus	picornavirus	NNP
cord-254895-ym0jsir5	407	1	Synthetic	synthetic	JJ
cord-254895-ym0jsir5	407	2	TLR	TLR	NNP
cord-254895-ym0jsir5	407	3	agonists	agonist	NNS
cord-254895-ym0jsir5	407	4	reveal	reveal	VBP
cord-254895-ym0jsir5	407	5	functional	functional	JJ
cord-254895-ym0jsir5	407	6	differences	difference	NNS
cord-254895-ym0jsir5	407	7	between	between	IN
cord-254895-ym0jsir5	407	8	human	human	JJ
cord-254895-ym0jsir5	407	9	TLR7	TLR7	NNP
cord-254895-ym0jsir5	407	10	and	and	CC
cord-254895-ym0jsir5	407	11	TLR8	TLR8	NNP
cord-254895-ym0jsir5	407	12	Properties	property	NNS
cord-254895-ym0jsir5	407	13	regulating	regulate	VBG
cord-254895-ym0jsir5	407	14	the	the	DT
cord-254895-ym0jsir5	407	15	nature	nature	NN
cord-254895-ym0jsir5	407	16	of	of	IN
cord-254895-ym0jsir5	407	17	the	the	DT
cord-254895-ym0jsir5	407	18	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	407	19	dendritic	dendritic	JJ
cord-254895-ym0jsir5	407	20	cell	cell	NN
cord-254895-ym0jsir5	407	21	response	response	NN
cord-254895-ym0jsir5	407	22	to	to	IN
cord-254895-ym0jsir5	407	23	Toll	Toll	NNP
cord-254895-ym0jsir5	407	24	-	-	HYPH
cord-254895-ym0jsir5	407	25	like	like	JJ
cord-254895-ym0jsir5	407	26	receptor	receptor	NN
cord-254895-ym0jsir5	407	27	9	9	CD
cord-254895-ym0jsir5	407	28	activation	activation	NN
cord-254895-ym0jsir5	407	29	Modulation	modulation	NN
cord-254895-ym0jsir5	407	30	of	of	IN
cord-254895-ym0jsir5	407	31	the	the	DT
cord-254895-ym0jsir5	407	32	interferon	interferon	NN
cord-254895-ym0jsir5	407	33	antiviral	antiviral	JJ
cord-254895-ym0jsir5	407	34	response	response	NN
cord-254895-ym0jsir5	407	35	by	by	IN
cord-254895-ym0jsir5	407	36	the	the	DT
cord-254895-ym0jsir5	407	37	TBK1	TBK1	NNP
cord-254895-ym0jsir5	407	38	/	/	SYM
cord-254895-ym0jsir5	407	39	IKKI	IKKI	NNP
cord-254895-ym0jsir5	407	40	adaptor	adaptor	NN
cord-254895-ym0jsir5	407	41	protein	protein	NN
cord-254895-ym0jsir5	407	42	tank	tank	NN
cord-254895-ym0jsir5	407	43	Rational	rational	JJ
cord-254895-ym0jsir5	407	44	design	design	NN
cord-254895-ym0jsir5	407	45	of	of	IN
cord-254895-ym0jsir5	407	46	new	new	JJ
cord-254895-ym0jsir5	407	47	CpG	CpG	NNP
cord-254895-ym0jsir5	407	48	oligonucleotides	oligonucleotide	NNS
cord-254895-ym0jsir5	407	49	that	that	WDT
cord-254895-ym0jsir5	407	50	combine	combine	VBP
cord-254895-ym0jsir5	407	51	B	b	NN
cord-254895-ym0jsir5	407	52	cell	cell	NN
cord-254895-ym0jsir5	407	53	activation	activation	NN
cord-254895-ym0jsir5	407	54	with	with	IN
cord-254895-ym0jsir5	407	55	high	high	JJ
cord-254895-ym0jsir5	407	56	IFN	IFN	NNP
cord-254895-ym0jsir5	407	57	-	-	HYPH
cord-254895-ym0jsir5	407	58	alpha	alpha	NN
cord-254895-ym0jsir5	407	59	induction	induction	NN
cord-254895-ym0jsir5	407	60	in	in	IN
cord-254895-ym0jsir5	407	61	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	407	62	dendritic	dendritic	JJ
cord-254895-ym0jsir5	407	63	cells	cell	NNS
cord-254895-ym0jsir5	408	1	Species	species	NN
cord-254895-ym0jsir5	408	2	-	-	HYPH
cord-254895-ym0jsir5	408	3	specific	specific	JJ
cord-254895-ym0jsir5	408	4	recognition	recognition	NN
cord-254895-ym0jsir5	408	5	of	of	IN
cord-254895-ym0jsir5	408	6	single	single	RB
cord-254895-ym0jsir5	408	7	-	-	HYPH
cord-254895-ym0jsir5	408	8	stranded	strand	VBN
cord-254895-ym0jsir5	408	9	RNA	RNA	NNP
cord-254895-ym0jsir5	408	10	via	via	IN
cord-254895-ym0jsir5	408	11	toll	toll	NN
cord-254895-ym0jsir5	408	12	-	-	HYPH
cord-254895-ym0jsir5	408	13	like	like	JJ
cord-254895-ym0jsir5	408	14	receptor	receptor	NN
cord-254895-ym0jsir5	408	15	7	7	CD
cord-254895-ym0jsir5	408	16	and	and	CC
cord-254895-ym0jsir5	408	17	8	8	CD
cord-254895-ym0jsir5	408	18	Small	small	JJ
cord-254895-ym0jsir5	408	19	anti	anti	JJ
cord-254895-ym0jsir5	408	20	-	-	JJ
cord-254895-ym0jsir5	408	21	viral	viral	JJ
cord-254895-ym0jsir5	408	22	compounds	compound	NNS
cord-254895-ym0jsir5	408	23	activate	activate	VBP
cord-254895-ym0jsir5	408	24	immune	immune	JJ
cord-254895-ym0jsir5	408	25	cells	cell	NNS
cord-254895-ym0jsir5	408	26	via	via	IN
cord-254895-ym0jsir5	408	27	the	the	DT
cord-254895-ym0jsir5	408	28	TLR7	TLR7	NNP
cord-254895-ym0jsir5	408	29	MyD88-dependent	MyD88-dependent	NNP
cord-254895-ym0jsir5	408	30	signaling	signal	VBG
cord-254895-ym0jsir5	409	1	pathway	pathway	NNP
cord-254895-ym0jsir5	409	2	Herpes	Herpes	NNP
cord-254895-ym0jsir5	409	3	simplex	simplex	NN
cord-254895-ym0jsir5	409	4	virus	virus	NN
cord-254895-ym0jsir5	409	5	type-1	type-1	NN
cord-254895-ym0jsir5	409	6	induces	induce	VBZ
cord-254895-ym0jsir5	409	7	IFN	IFN	NNP
cord-254895-ym0jsir5	409	8	-	-	HYPH
cord-254895-ym0jsir5	409	9	alpha	alpha	NN
cord-254895-ym0jsir5	409	10	production	production	NN
cord-254895-ym0jsir5	409	11	via	via	IN
cord-254895-ym0jsir5	409	12	Toll	toll	NN
cord-254895-ym0jsir5	409	13	-	-	HYPH
cord-254895-ym0jsir5	409	14	like	like	JJ
cord-254895-ym0jsir5	409	15	receptor	receptor	NN
cord-254895-ym0jsir5	409	16	9-dependent	9-dependent	CD
cord-254895-ym0jsir5	409	17	and	and	CC
cord-254895-ym0jsir5	409	18	-independent	-independent	JJ
cord-254895-ym0jsir5	409	19	pathways	pathway	NNS
cord-254895-ym0jsir5	409	20	Identification	Identification	NNP
cord-254895-ym0jsir5	409	21	of	of	IN
cord-254895-ym0jsir5	409	22	Lps2	Lps2	NNP
cord-254895-ym0jsir5	409	23	as	as	IN
cord-254895-ym0jsir5	409	24	a	a	DT
cord-254895-ym0jsir5	409	25	key	key	JJ
cord-254895-ym0jsir5	409	26	transducer	transducer	NN
cord-254895-ym0jsir5	409	27	of	of	IN
cord-254895-ym0jsir5	409	28	MyD88-independent	MyD88-independent	NNP
cord-254895-ym0jsir5	409	29	TIR	TIR	NNP
cord-254895-ym0jsir5	409	30	signalling	signal	VBG
cord-254895-ym0jsir5	409	31	IRFs	irfs	NN
cord-254895-ym0jsir5	409	32	:	:	:
cord-254895-ym0jsir5	409	33	master	master	NN
cord-254895-ym0jsir5	409	34	regulators	regulator	NNS
cord-254895-ym0jsir5	409	35	of	of	IN
cord-254895-ym0jsir5	409	36	signalling	signal	VBG
cord-254895-ym0jsir5	409	37	by	by	IN
cord-254895-ym0jsir5	409	38	Toll	toll	NN
cord-254895-ym0jsir5	409	39	-	-	HYPH
cord-254895-ym0jsir5	409	40	like	like	JJ
cord-254895-ym0jsir5	409	41	receptors	receptor	NNS
cord-254895-ym0jsir5	409	42	and	and	CC
cord-254895-ym0jsir5	409	43	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	409	44	patternrecognition	patternrecognition	NN
cord-254895-ym0jsir5	409	45	receptors	receptor	NNS
cord-254895-ym0jsir5	409	46	Role	role	NN
cord-254895-ym0jsir5	409	47	of	of	IN
cord-254895-ym0jsir5	409	48	a	a	DT
cord-254895-ym0jsir5	409	49	transductional	transductional	JJ
cord-254895-ym0jsir5	409	50	-	-	HYPH
cord-254895-ym0jsir5	409	51	transcriptional	transcriptional	NN
cord-254895-ym0jsir5	409	52	processor	processor	NN
cord-254895-ym0jsir5	409	53	complex	complex	NN
cord-254895-ym0jsir5	409	54	involving	involve	VBG
cord-254895-ym0jsir5	409	55	MyD88	MyD88	NNP
cord-254895-ym0jsir5	409	56	and	and	CC
cord-254895-ym0jsir5	409	57	IRF-7	IRF-7	NNP
cord-254895-ym0jsir5	409	58	in	in	IN
cord-254895-ym0jsir5	409	59	Toll	Toll	NNP
cord-254895-ym0jsir5	409	60	-	-	HYPH
cord-254895-ym0jsir5	409	61	like	like	JJ
cord-254895-ym0jsir5	409	62	receptor	receptor	NN
cord-254895-ym0jsir5	409	63	signaling	signal	VBG
cord-254895-ym0jsir5	409	64	Spatiotemporal	spatiotemporal	JJ
cord-254895-ym0jsir5	409	65	regulation	regulation	NN
cord-254895-ym0jsir5	409	66	of	of	IN
cord-254895-ym0jsir5	409	67	MyD88-IRF-7	MyD88-IRF-7	NNS
cord-254895-ym0jsir5	409	68	signalling	signal	VBG
cord-254895-ym0jsir5	409	69	for	for	IN
cord-254895-ym0jsir5	409	70	robust	robust	JJ
cord-254895-ym0jsir5	409	71	type	type	NN
cord-254895-ym0jsir5	409	72	-	-	:
cord-254895-ym0jsir5	409	73	I	i	NN
cord-254895-ym0jsir5	410	1	interferon	interferon	NNP
cord-254895-ym0jsir5	410	2	induction	induction	NNP
cord-254895-ym0jsir5	411	1	IRF-7	IRF-7	NNP
cord-254895-ym0jsir5	411	2	is	be	VBZ
cord-254895-ym0jsir5	411	3	the	the	DT
cord-254895-ym0jsir5	411	4	master	master	NN
cord-254895-ym0jsir5	411	5	regulator	regulator	NN
cord-254895-ym0jsir5	411	6	of	of	IN
cord-254895-ym0jsir5	411	7	type	type	NN
cord-254895-ym0jsir5	411	8	-	-	:
cord-254895-ym0jsir5	411	9	I	-PRON-	PRP
cord-254895-ym0jsir5	411	10	interferon	interferon	NN
cord-254895-ym0jsir5	411	11	-	-	HYPH
cord-254895-ym0jsir5	411	12	dependent	dependent	JJ
cord-254895-ym0jsir5	411	13	immune	immune	JJ
cord-254895-ym0jsir5	411	14	responses	response	NNS
cord-254895-ym0jsir5	411	15	Sequence	sequence	NN
cord-254895-ym0jsir5	411	16	-	-	HYPH
cord-254895-ym0jsir5	411	17	specific	specific	JJ
cord-254895-ym0jsir5	411	18	potent	potent	JJ
cord-254895-ym0jsir5	411	19	induction	induction	NN
cord-254895-ym0jsir5	411	20	of	of	IN
cord-254895-ym0jsir5	411	21	IFN	IFN	NNP
cord-254895-ym0jsir5	411	22	-	-	HYPH
cord-254895-ym0jsir5	411	23	alpha	alpha	NN
cord-254895-ym0jsir5	411	24	by	by	IN
cord-254895-ym0jsir5	411	25	short	short	JJ
cord-254895-ym0jsir5	411	26	interfering	interfere	VBG
cord-254895-ym0jsir5	411	27	RNA	RNA	NNP
cord-254895-ym0jsir5	411	28	in	in	IN
cord-254895-ym0jsir5	411	29	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	411	30	dendritic	dendritic	JJ
cord-254895-ym0jsir5	411	31	cells	cell	NNS
cord-254895-ym0jsir5	411	32	through	through	IN
cord-254895-ym0jsir5	411	33	TLR7	TLR7	NNP
cord-254895-ym0jsir5	411	34	0	0	CD
cord-254895-ym0jsir5	412	1	-Triphosphate	-Triphosphate	NNP
cord-254895-ym0jsir5	412	2	RNA	RNA	NNP
cord-254895-ym0jsir5	412	3	is	be	VBZ
cord-254895-ym0jsir5	412	4	the	the	DT
cord-254895-ym0jsir5	412	5	ligand	ligand	NN
cord-254895-ym0jsir5	412	6	for	for	IN
cord-254895-ym0jsir5	412	7	RIG	rig	NN
cord-254895-ym0jsir5	412	8	-	-	:
cord-254895-ym0jsir5	412	9	I	i	NN
cord-254895-ym0jsir5	412	10	IkappaB	IkappaB	NNP
cord-254895-ym0jsir5	412	11	kinase	kinase	NN
cord-254895-ym0jsir5	412	12	-	-	HYPH
cord-254895-ym0jsir5	412	13	alpha	alpha	NN
cord-254895-ym0jsir5	412	14	is	be	VBZ
cord-254895-ym0jsir5	412	15	critical	critical	JJ
cord-254895-ym0jsir5	412	16	for	for	IN
cord-254895-ym0jsir5	412	17	interferon	interferon	NN
cord-254895-ym0jsir5	412	18	-	-	HYPH
cord-254895-ym0jsir5	412	19	alpha	alpha	NN
cord-254895-ym0jsir5	412	20	production	production	NN
cord-254895-ym0jsir5	412	21	induced	induce	VBN
cord-254895-ym0jsir5	412	22	by	by	IN
cord-254895-ym0jsir5	412	23	Toll	Toll	NNP
cord-254895-ym0jsir5	412	24	-	-	HYPH
cord-254895-ym0jsir5	412	25	like	like	JJ
cord-254895-ym0jsir5	412	26	receptors	receptor	NNS
cord-254895-ym0jsir5	412	27	7	7	CD
cord-254895-ym0jsir5	412	28	and	and	CC
cord-254895-ym0jsir5	412	29	9	9	CD
cord-254895-ym0jsir5	412	30	NODs	nod	NNS
cord-254895-ym0jsir5	412	31	:	:	:
cord-254895-ym0jsir5	412	32	intracellular	intracellular	JJ
cord-254895-ym0jsir5	412	33	proteins	protein	NNS
cord-254895-ym0jsir5	412	34	involved	involve	VBN
cord-254895-ym0jsir5	412	35	in	in	IN
cord-254895-ym0jsir5	412	36	inflammation	inflammation	NN
cord-254895-ym0jsir5	412	37	and	and	CC
cord-254895-ym0jsir5	412	38	apoptosis	apoptosis	NN
cord-254895-ym0jsir5	412	39	A	a	DT
cord-254895-ym0jsir5	412	40	Toll	toll	NN
cord-254895-ym0jsir5	412	41	-	-	HYPH
cord-254895-ym0jsir5	412	42	like	like	JJ
cord-254895-ym0jsir5	412	43	receptorindependent	receptorindependent	NN
cord-254895-ym0jsir5	412	44	antiviral	antiviral	JJ
cord-254895-ym0jsir5	412	45	response	response	NN
cord-254895-ym0jsir5	412	46	induced	induce	VBN
cord-254895-ym0jsir5	412	47	by	by	IN
cord-254895-ym0jsir5	412	48	double	double	RB
cord-254895-ym0jsir5	412	49	-	-	HYPH
cord-254895-ym0jsir5	412	50	stranded	strand	VBN
cord-254895-ym0jsir5	412	51	B	b	NN
cord-254895-ym0jsir5	412	52	-	-	HYPH
cord-254895-ym0jsir5	412	53	form	form	NN
cord-254895-ym0jsir5	412	54	DNA	DNA	NNP
cord-254895-ym0jsir5	412	55	Comparative	Comparative	NNP
cord-254895-ym0jsir5	412	56	analysis	analysis	NN
cord-254895-ym0jsir5	412	57	of	of	IN
cord-254895-ym0jsir5	412	58	IRF	IRF	NNP
cord-254895-ym0jsir5	412	59	and	and	CC
cord-254895-ym0jsir5	412	60	IFN	IFN	NNP
cord-254895-ym0jsir5	412	61	-	-	HYPH
cord-254895-ym0jsir5	412	62	alpha	alpha	NN
cord-254895-ym0jsir5	412	63	expression	expression	NN
cord-254895-ym0jsir5	412	64	in	in	IN
cord-254895-ym0jsir5	412	65	human	human	JJ
cord-254895-ym0jsir5	412	66	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	412	67	and	and	CC
cord-254895-ym0jsir5	412	68	monocyte	monocyte	NNP
cord-254895-ym0jsir5	412	69	-	-	HYPH
cord-254895-ym0jsir5	412	70	derived	derive	VBN
cord-254895-ym0jsir5	412	71	dendritic	dendritic	JJ
cord-254895-ym0jsir5	412	72	cells	cell	NNS
cord-254895-ym0jsir5	412	73	Functional	functional	JJ
cord-254895-ym0jsir5	412	74	and	and	CC
cord-254895-ym0jsir5	412	75	therapeutic	therapeutic	JJ
cord-254895-ym0jsir5	412	76	analysis	analysis	NN
cord-254895-ym0jsir5	412	77	of	of	IN
cord-254895-ym0jsir5	412	78	hepatitis	hepatitis	NN
cord-254895-ym0jsir5	412	79	C	C	NNP
cord-254895-ym0jsir5	412	80	virus	virus	NN
cord-254895-ym0jsir5	412	81	NS3/4A	ns3/4a	IN
cord-254895-ym0jsir5	412	82	protease	protease	NN
cord-254895-ym0jsir5	412	83	control	control	NN
cord-254895-ym0jsir5	412	84	of	of	IN
cord-254895-ym0jsir5	412	85	antiviral	antiviral	JJ
cord-254895-ym0jsir5	412	86	immune	immune	JJ
cord-254895-ym0jsir5	412	87	defense	defense	NN
cord-254895-ym0jsir5	412	88	Human	Human	NNP
cord-254895-ym0jsir5	412	89	TLR7	TLR7	NNP
cord-254895-ym0jsir5	412	90	or	or	CC
cord-254895-ym0jsir5	412	91	TLR8	TLR8	NNP
cord-254895-ym0jsir5	412	92	independently	independently	RB
cord-254895-ym0jsir5	412	93	confer	confer	VB
cord-254895-ym0jsir5	412	94	responsiveness	responsiveness	NN
cord-254895-ym0jsir5	412	95	to	to	IN
cord-254895-ym0jsir5	412	96	the	the	DT
cord-254895-ym0jsir5	412	97	antiviral	antiviral	JJ
cord-254895-ym0jsir5	412	98	compound	compound	NN
cord-254895-ym0jsir5	412	99	R-848	r-848	NN
cord-254895-ym0jsir5	412	100	MDA-5	MDA-5	NNP
cord-254895-ym0jsir5	412	101	:	:	:
cord-254895-ym0jsir5	413	1	An	an	DT
cord-254895-ym0jsir5	413	2	interferoninducible	interferoninducible	JJ
cord-254895-ym0jsir5	413	3	putative	putative	JJ
cord-254895-ym0jsir5	413	4	RNA	RNA	NNP
cord-254895-ym0jsir5	413	5	helicase	helicase	NN
cord-254895-ym0jsir5	413	6	with	with	IN
cord-254895-ym0jsir5	413	7	double	double	RB
cord-254895-ym0jsir5	413	8	-	-	HYPH
cord-254895-ym0jsir5	413	9	stranded	strand	VBN
cord-254895-ym0jsir5	413	10	RNA	rna	NN
cord-254895-ym0jsir5	413	11	-	-	HYPH
cord-254895-ym0jsir5	413	12	dependent	dependent	JJ
cord-254895-ym0jsir5	413	13	ATPase	ATPase	NNP
cord-254895-ym0jsir5	413	14	activity	activity	NN
cord-254895-ym0jsir5	413	15	and	and	CC
cord-254895-ym0jsir5	413	16	melanoma	melanoma	NN
cord-254895-ym0jsir5	413	17	growthsuppressive	growthsuppressive	NNP
cord-254895-ym0jsir5	413	18	properties	property	NNS
cord-254895-ym0jsir5	413	19	Cell	cell	NN
cord-254895-ym0jsir5	413	20	type	type	NN
cord-254895-ym0jsir5	413	21	-	-	HYPH
cord-254895-ym0jsir5	413	22	specific	specific	JJ
cord-254895-ym0jsir5	413	23	involvement	involvement	NN
cord-254895-ym0jsir5	413	24	of	of	IN
cord-254895-ym0jsir5	413	25	RIG	rig	NN
cord-254895-ym0jsir5	413	26	-	-	:
cord-254895-ym0jsir5	413	27	I	-PRON-	PRP
cord-254895-ym0jsir5	413	28	in	in	IN
cord-254895-ym0jsir5	413	29	antiviral	antiviral	JJ
cord-254895-ym0jsir5	413	30	response	response	NN
cord-254895-ym0jsir5	413	31	Differential	differential	JJ
cord-254895-ym0jsir5	413	32	roles	role	NNS
cord-254895-ym0jsir5	413	33	of	of	IN
cord-254895-ym0jsir5	413	34	MDA5	MDA5	NNP
cord-254895-ym0jsir5	413	35	and	and	CC
cord-254895-ym0jsir5	413	36	RIG	rig	NN
cord-254895-ym0jsir5	414	1	-I	-i	DT
cord-254895-ym0jsir5	414	2	helicases	helicase	NNS
cord-254895-ym0jsir5	414	3	in	in	IN
cord-254895-ym0jsir5	414	4	the	the	DT
cord-254895-ym0jsir5	414	5	recognition	recognition	NN
cord-254895-ym0jsir5	414	6	of	of	IN
cord-254895-ym0jsir5	414	7	RNA	RNA	NNP
cord-254895-ym0jsir5	414	8	viruses	virus	NNS
cord-254895-ym0jsir5	415	1	Interferonalpha	Interferonalpha	NNP
cord-254895-ym0jsir5	415	2	induction	induction	NN
cord-254895-ym0jsir5	415	3	through	through	IN
cord-254895-ym0jsir5	415	4	Toll	toll	NN
cord-254895-ym0jsir5	415	5	-	-	HYPH
cord-254895-ym0jsir5	415	6	like	like	JJ
cord-254895-ym0jsir5	415	7	receptors	receptor	NNS
cord-254895-ym0jsir5	415	8	involves	involve	VBZ
cord-254895-ym0jsir5	415	9	a	a	DT
cord-254895-ym0jsir5	415	10	direct	direct	JJ
cord-254895-ym0jsir5	415	11	interaction	interaction	NN
cord-254895-ym0jsir5	415	12	of	of	IN
cord-254895-ym0jsir5	415	13	IRF7	IRF7	NNP
cord-254895-ym0jsir5	415	14	with	with	IN
cord-254895-ym0jsir5	415	15	MyD88	MyD88	NNPS
cord-254895-ym0jsir5	415	16	and	and	CC
cord-254895-ym0jsir5	415	17	TRAF6	TRAF6	''
cord-254895-ym0jsir5	415	18	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	415	19	,	,	,
cord-254895-ym0jsir5	415	20	an	an	DT
cord-254895-ym0jsir5	415	21	adaptor	adaptor	NN
cord-254895-ym0jsir5	415	22	triggering	trigger	VBG
cord-254895-ym0jsir5	415	23	RIG	rig	NN
cord-254895-ym0jsir5	415	24	-	-	HYPH
cord-254895-ym0jsir5	415	25	I	i	NN
cord-254895-ym0jsir5	415	26	-	-	HYPH
cord-254895-ym0jsir5	415	27	and	and	CC
cord-254895-ym0jsir5	415	28	Mda5-mediated	Mda5-mediated	NNP
cord-254895-ym0jsir5	416	1	type	type	NN
cord-254895-ym0jsir5	416	2	I	-PRON-	PRP
cord-254895-ym0jsir5	416	3	interferon	interferon	VBD
cord-254895-ym0jsir5	416	4	induction	induction	NN
cord-254895-ym0jsir5	416	5	Activation	Activation	NNP
cord-254895-ym0jsir5	416	6	with	with	IN
cord-254895-ym0jsir5	416	7	CpG	CpG	NNP
cord-254895-ym0jsir5	416	8	-	-	HYPH
cord-254895-ym0jsir5	416	9	A	A	NNP
cord-254895-ym0jsir5	416	10	and	and	CC
cord-254895-ym0jsir5	416	11	CpG	cpg	NN
cord-254895-ym0jsir5	416	12	-	-	HYPH
cord-254895-ym0jsir5	416	13	B	B	NNP
cord-254895-ym0jsir5	416	14	oligonucleotides	oligonucleotide	NNS
cord-254895-ym0jsir5	416	15	reveals	reveal	VBZ
cord-254895-ym0jsir5	416	16	two	two	CD
cord-254895-ym0jsir5	416	17	distinct	distinct	JJ
cord-254895-ym0jsir5	416	18	regulatory	regulatory	JJ
cord-254895-ym0jsir5	416	19	pathways	pathway	NNS
cord-254895-ym0jsir5	416	20	of	of	IN
cord-254895-ym0jsir5	416	21	type	type	NN
cord-254895-ym0jsir5	417	1	I	-PRON-	PRP
cord-254895-ym0jsir5	417	2	IFN	IFN	NNP
cord-254895-ym0jsir5	417	3	synthesis	synthesis	NN
cord-254895-ym0jsir5	417	4	in	in	IN
cord-254895-ym0jsir5	417	5	human	human	JJ
cord-254895-ym0jsir5	417	6	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	417	7	dendritic	dendritic	NN
cord-254895-ym0jsir5	417	8	cells	cell	NNS
cord-254895-ym0jsir5	417	9	Spontaneous	spontaneous	JJ
cord-254895-ym0jsir5	417	10	formation	formation	NN
cord-254895-ym0jsir5	417	11	of	of	IN
cord-254895-ym0jsir5	417	12	nucleic	nucleic	JJ
cord-254895-ym0jsir5	417	13	acid	acid	NN
cord-254895-ym0jsir5	417	14	-	-	HYPH
cord-254895-ym0jsir5	417	15	based	base	VBN
cord-254895-ym0jsir5	417	16	nanoparticles	nanoparticle	NNS
cord-254895-ym0jsir5	417	17	is	be	VBZ
cord-254895-ym0jsir5	417	18	responsible	responsible	JJ
cord-254895-ym0jsir5	417	19	for	for	IN
cord-254895-ym0jsir5	417	20	high	high	JJ
cord-254895-ym0jsir5	417	21	interferonalpha	interferonalpha	NNP
cord-254895-ym0jsir5	417	22	induction	induction	NN
cord-254895-ym0jsir5	417	23	by	by	IN
cord-254895-ym0jsir5	417	24	CpG	CpG	NNP
cord-254895-ym0jsir5	417	25	-	-	HYPH
cord-254895-ym0jsir5	417	26	A	A	NNP
cord-254895-ym0jsir5	417	27	in	in	IN
cord-254895-ym0jsir5	417	28	plasmacytoid	plasmacytoid	JJ
cord-254895-ym0jsir5	417	29	dendritic	dendritic	JJ
cord-254895-ym0jsir5	417	30	cells	cell	NNS
cord-254895-ym0jsir5	417	31	Overexpression	Overexpression	NNP
cord-254895-ym0jsir5	417	32	of	of	IN
cord-254895-ym0jsir5	417	33	Helicard	Helicard	NNP
cord-254895-ym0jsir5	417	34	,	,	,
cord-254895-ym0jsir5	417	35	a	a	DT
cord-254895-ym0jsir5	417	36	CARD	card	NN
cord-254895-ym0jsir5	417	37	-	-	HYPH
cord-254895-ym0jsir5	417	38	containing	contain	VBG
cord-254895-ym0jsir5	417	39	helicase	helicase	NN
cord-254895-ym0jsir5	417	40	cleaved	cleave	VBN
cord-254895-ym0jsir5	417	41	during	during	IN
cord-254895-ym0jsir5	417	42	apoptosis	apoptosis	NN
cord-254895-ym0jsir5	417	43	,	,	,
cord-254895-ym0jsir5	417	44	accelerates	accelerate	VBZ
cord-254895-ym0jsir5	417	45	DNA	dna	NN
cord-254895-ym0jsir5	417	46	degradation	degradation	NN
cord-254895-ym0jsir5	417	47	Identification	identification	NN
cord-254895-ym0jsir5	417	48	of	of	IN
cord-254895-ym0jsir5	417	49	CpG	CpG	NNP
cord-254895-ym0jsir5	417	50	oligonucleotide	oligonucleotide	NN
cord-254895-ym0jsir5	417	51	sequences	sequence	NNS
cord-254895-ym0jsir5	417	52	with	with	IN
cord-254895-ym0jsir5	417	53	high	high	JJ
cord-254895-ym0jsir5	417	54	induction	induction	NN
cord-254895-ym0jsir5	417	55	of	of	IN
cord-254895-ym0jsir5	417	56	IFN	IFN	NNP
cord-254895-ym0jsir5	417	57	-	-	HYPH
cord-254895-ym0jsir5	417	58	alpha	alpha	NN
cord-254895-ym0jsir5	417	59	/	/	SYM
cord-254895-ym0jsir5	417	60	beta	beta	NN
cord-254895-ym0jsir5	417	61	in	in	IN
cord-254895-ym0jsir5	417	62	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	417	63	dendritic	dendritic	JJ
cord-254895-ym0jsir5	417	64	cells	cell	NNS
cord-254895-ym0jsir5	417	65	TLR9-dependent	TLR9-dependent	NNP
cord-254895-ym0jsir5	417	66	recognition	recognition	NN
cord-254895-ym0jsir5	417	67	of	of	IN
cord-254895-ym0jsir5	417	68	MCMV	MCMV	NNP
cord-254895-ym0jsir5	417	69	by	by	IN
cord-254895-ym0jsir5	417	70	IPC	IPC	NNP
cord-254895-ym0jsir5	417	71	and	and	CC
cord-254895-ym0jsir5	417	72	DC	DC	NNP
cord-254895-ym0jsir5	417	73	generates	generate	VBZ
cord-254895-ym0jsir5	417	74	coordinated	coordinated	JJ
cord-254895-ym0jsir5	417	75	cytokine	cytokine	NN
cord-254895-ym0jsir5	417	76	responses	response	NNS
cord-254895-ym0jsir5	417	77	that	that	WDT
cord-254895-ym0jsir5	417	78	activate	activate	VBP
cord-254895-ym0jsir5	417	79	antiviral	antiviral	JJ
cord-254895-ym0jsir5	417	80	NK	NK	NNP
cord-254895-ym0jsir5	417	81	cell	cell	NN
cord-254895-ym0jsir5	417	82	function	function	NN
cord-254895-ym0jsir5	417	83	Herpes	Herpes	NNP
cord-254895-ym0jsir5	417	84	simplex	simplex	NN
cord-254895-ym0jsir5	417	85	virus	virus	NN
cord-254895-ym0jsir5	417	86	type	type	NN
cord-254895-ym0jsir5	417	87	1	1	CD
cord-254895-ym0jsir5	417	88	activates	activate	VBZ
cord-254895-ym0jsir5	417	89	murine	murine	JJ
cord-254895-ym0jsir5	417	90	natural	natural	JJ
cord-254895-ym0jsir5	417	91	interferon	interferon	NN
cord-254895-ym0jsir5	417	92	-	-	HYPH
cord-254895-ym0jsir5	417	93	producing	produce	VBG
cord-254895-ym0jsir5	417	94	cells	cell	NNS
cord-254895-ym0jsir5	417	95	through	through	IN
cord-254895-ym0jsir5	417	96	toll	toll	NN
cord-254895-ym0jsir5	417	97	-	-	HYPH
cord-254895-ym0jsir5	417	98	like	like	JJ
cord-254895-ym0jsir5	417	99	receptor	receptor	NN
cord-254895-ym0jsir5	417	100	9	9	CD
cord-254895-ym0jsir5	417	101	Essential	essential	JJ
cord-254895-ym0jsir5	417	102	role	role	NN
cord-254895-ym0jsir5	417	103	of	of	IN
cord-254895-ym0jsir5	417	104	IPS-1	IPS-1	NNP
cord-254895-ym0jsir5	417	105	in	in	IN
cord-254895-ym0jsir5	417	106	innate	innate	JJ
cord-254895-ym0jsir5	417	107	immune	immune	JJ
cord-254895-ym0jsir5	417	108	responses	response	NNS
cord-254895-ym0jsir5	417	109	against	against	IN
cord-254895-ym0jsir5	417	110	RNA	RNA	NNP
cord-254895-ym0jsir5	417	111	viruses	virus	NNS
cord-254895-ym0jsir5	418	1	Detrimental	detrimental	JJ
cord-254895-ym0jsir5	418	2	contribution	contribution	NN
cord-254895-ym0jsir5	418	3	of	of	IN
cord-254895-ym0jsir5	418	4	the	the	DT
cord-254895-ym0jsir5	418	5	Toll	Toll	NNP
cord-254895-ym0jsir5	418	6	-	-	HYPH
cord-254895-ym0jsir5	418	7	like	like	JJ
cord-254895-ym0jsir5	418	8	receptor	receptor	NN
cord-254895-ym0jsir5	418	9	(	(	-LRB-
cord-254895-ym0jsir5	418	10	TLR)3	tlr)3	XX
cord-254895-ym0jsir5	418	11	to	to	TO
cord-254895-ym0jsir5	418	12	influenza	influenza	VB
cord-254895-ym0jsir5	418	13	A	a	DT
cord-254895-ym0jsir5	418	14	virus	virus	NN
cord-254895-ym0jsir5	418	15	-	-	HYPH
cord-254895-ym0jsir5	418	16	induced	induce	VBN
cord-254895-ym0jsir5	418	17	acute	acute	JJ
cord-254895-ym0jsir5	418	18	pneumonia	pneumonia	NN
cord-254895-ym0jsir5	418	19	Cutting	cutting	NN
cord-254895-ym0jsir5	418	20	edge	edge	NN
cord-254895-ym0jsir5	419	1	:	:	:
cord-254895-ym0jsir5	419	2	Influenza	Influenza	NNP
cord-254895-ym0jsir5	419	3	A	a	DT
cord-254895-ym0jsir5	419	4	virus	virus	NN
cord-254895-ym0jsir5	419	5	activates	activate	VBZ
cord-254895-ym0jsir5	419	6	TLR3-dependent	TLR3-dependent	NNP
cord-254895-ym0jsir5	419	7	inflammatory	inflammatory	JJ
cord-254895-ym0jsir5	419	8	and	and	CC
cord-254895-ym0jsir5	419	9	RIG	rig	NN
cord-254895-ym0jsir5	419	10	-	-	HYPH
cord-254895-ym0jsir5	419	11	I	i	NN
cord-254895-ym0jsir5	419	12	-	-	HYPH
cord-254895-ym0jsir5	419	13	dependent	dependent	JJ
cord-254895-ym0jsir5	419	14	antiviral	antiviral	JJ
cord-254895-ym0jsir5	419	15	responses	response	NNS
cord-254895-ym0jsir5	419	16	in	in	IN
cord-254895-ym0jsir5	419	17	human	human	JJ
cord-254895-ym0jsir5	419	18	lung	lung	NN
cord-254895-ym0jsir5	419	19	epithelial	epithelial	NN
cord-254895-ym0jsir5	419	20	cells	cell	NNS
cord-254895-ym0jsir5	419	21	Autophagy	autophagy	NN
cord-254895-ym0jsir5	419	22	-	-	HYPH
cord-254895-ym0jsir5	419	23	dependent	dependent	JJ
cord-254895-ym0jsir5	419	24	viral	viral	JJ
cord-254895-ym0jsir5	419	25	recognition	recognition	NN
cord-254895-ym0jsir5	419	26	by	by	IN
cord-254895-ym0jsir5	419	27	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	419	28	dendritic	dendritic	JJ
cord-254895-ym0jsir5	419	29	cells	cell	NNS
cord-254895-ym0jsir5	420	1	Hepatitis	Hepatitis	NNP
cord-254895-ym0jsir5	420	2	C	C	NNP
cord-254895-ym0jsir5	420	3	virus	virus	NN
cord-254895-ym0jsir5	420	4	protease	protease	NN
cord-254895-ym0jsir5	420	5	NS3/4A	ns3/4a	PRP
cord-254895-ym0jsir5	420	6	cleaves	cleave	VBZ
cord-254895-ym0jsir5	420	7	mitochondrial	mitochondrial	JJ
cord-254895-ym0jsir5	420	8	antiviral	antiviral	JJ
cord-254895-ym0jsir5	420	9	signaling	signal	VBG
cord-254895-ym0jsir5	420	10	protein	protein	NN
cord-254895-ym0jsir5	420	11	off	off	IN
cord-254895-ym0jsir5	420	12	the	the	DT
cord-254895-ym0jsir5	420	13	mitochondria	mitochondrion	NNS
cord-254895-ym0jsir5	420	14	to	to	TO
cord-254895-ym0jsir5	420	15	evade	evade	VB
cord-254895-ym0jsir5	420	16	innate	innate	JJ
cord-254895-ym0jsir5	420	17	immunity	immunity	NN
cord-254895-ym0jsir5	420	18	Viral	viral	JJ
cord-254895-ym0jsir5	420	19	and	and	CC
cord-254895-ym0jsir5	420	20	therapeutic	therapeutic	JJ
cord-254895-ym0jsir5	420	21	control	control	NN
cord-254895-ym0jsir5	420	22	of	of	IN
cord-254895-ym0jsir5	420	23	IFN	IFN	NNP
cord-254895-ym0jsir5	420	24	-	-	HYPH
cord-254895-ym0jsir5	420	25	beta	beta	NN
cord-254895-ym0jsir5	420	26	promoter	promoter	NN
cord-254895-ym0jsir5	420	27	stimulator	stimulator	NN
cord-254895-ym0jsir5	420	28	1	1	CD
cord-254895-ym0jsir5	420	29	during	during	IN
cord-254895-ym0jsir5	420	30	hepatitis	hepatitis	NN
cord-254895-ym0jsir5	420	31	C	C	NNP
cord-254895-ym0jsir5	420	32	virus	virus	NN
cord-254895-ym0jsir5	420	33	infection	infection	NN
cord-254895-ym0jsir5	420	34	TLR	TLR	NNP
cord-254895-ym0jsir5	420	35	-	-	HYPH
cord-254895-ym0jsir5	420	36	independent	independent	JJ
cord-254895-ym0jsir5	420	37	induction	induction	NN
cord-254895-ym0jsir5	420	38	of	of	IN
cord-254895-ym0jsir5	420	39	dendritic	dendritic	JJ
cord-254895-ym0jsir5	420	40	cell	cell	NN
cord-254895-ym0jsir5	420	41	maturation	maturation	NN
cord-254895-ym0jsir5	420	42	and	and	CC
cord-254895-ym0jsir5	420	43	adaptive	adaptive	JJ
cord-254895-ym0jsir5	420	44	immunity	immunity	NN
cord-254895-ym0jsir5	420	45	by	by	IN
cord-254895-ym0jsir5	420	46	negative	negative	JJ
cord-254895-ym0jsir5	420	47	-	-	HYPH
cord-254895-ym0jsir5	420	48	strand	strand	NN
cord-254895-ym0jsir5	420	49	RNA	RNA	NNP
cord-254895-ym0jsir5	420	50	viruses	virus	NNS
cord-254895-ym0jsir5	421	1	Toll	toll	NN
cord-254895-ym0jsir5	421	2	-	-	HYPH
cord-254895-ym0jsir5	421	3	like	like	JJ
cord-254895-ym0jsir5	421	4	receptor	receptor	NN
cord-254895-ym0jsir5	421	5	9-mediated	9-mediated	CD
cord-254895-ym0jsir5	421	6	recognition	recognition	NN
cord-254895-ym0jsir5	421	7	of	of	IN
cord-254895-ym0jsir5	421	8	Herpes	Herpes	NNP
cord-254895-ym0jsir5	421	9	simplex	simplex	NNP
cord-254895-ym0jsir5	421	10	virus-2	virus-2	NNP
cord-254895-ym0jsir5	421	11	by	by	IN
cord-254895-ym0jsir5	421	12	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	421	13	dendritic	dendritic	NNP
cord-254895-ym0jsir5	421	14	cells	cell	NNS
cord-254895-ym0jsir5	421	15	Recognition	Recognition	NNP
cord-254895-ym0jsir5	421	16	of	of	IN
cord-254895-ym0jsir5	421	17	single	single	RB
cord-254895-ym0jsir5	421	18	-	-	HYPH
cord-254895-ym0jsir5	421	19	stranded	strand	VBN
cord-254895-ym0jsir5	421	20	RNA	RNA	NNP
cord-254895-ym0jsir5	421	21	viruses	virus	NNS
cord-254895-ym0jsir5	421	22	by	by	IN
cord-254895-ym0jsir5	421	23	Toll	toll	NN
cord-254895-ym0jsir5	421	24	-	-	HYPH
cord-254895-ym0jsir5	421	25	like	like	JJ
cord-254895-ym0jsir5	421	26	receptor	receptor	NN
cord-254895-ym0jsir5	421	27	7	7	CD
cord-254895-ym0jsir5	421	28	Cutting	cutting	NN
cord-254895-ym0jsir5	421	29	edge	edge	NN
cord-254895-ym0jsir5	421	30	:	:	:
cord-254895-ym0jsir5	421	31	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	421	32	dendritic	dendritic	JJ
cord-254895-ym0jsir5	421	33	cells	cell	NNS
cord-254895-ym0jsir5	421	34	provide	provide	VBP
cord-254895-ym0jsir5	421	35	innate	innate	JJ
cord-254895-ym0jsir5	421	36	immune	immune	JJ
cord-254895-ym0jsir5	421	37	protection	protection	NN
cord-254895-ym0jsir5	421	38	against	against	IN
cord-254895-ym0jsir5	421	39	mucosal	mucosal	JJ
cord-254895-ym0jsir5	421	40	viral	viral	JJ
cord-254895-ym0jsir5	421	41	infection	infection	NN
cord-254895-ym0jsir5	421	42	in	in	IN
cord-254895-ym0jsir5	421	43	situ	situ	VBG
cord-254895-ym0jsir5	421	44	Large	large	JJ
cord-254895-ym0jsir5	421	45	-	-	HYPH
cord-254895-ym0jsir5	421	46	scale	scale	NN
cord-254895-ym0jsir5	421	47	identification	identification	NN
cord-254895-ym0jsir5	421	48	and	and	CC
cord-254895-ym0jsir5	421	49	characterization	characterization	NN
cord-254895-ym0jsir5	421	50	of	of	IN
cord-254895-ym0jsir5	421	51	human	human	JJ
cord-254895-ym0jsir5	421	52	genes	gene	NNS
cord-254895-ym0jsir5	421	53	that	that	WDT
cord-254895-ym0jsir5	421	54	activate	activate	VBP
cord-254895-ym0jsir5	421	55	NF	NF	NNP
cord-254895-ym0jsir5	421	56	-	-	HYPH
cord-254895-ym0jsir5	421	57	kappaB	kappaB	NNP
cord-254895-ym0jsir5	421	58	and	and	CC
cord-254895-ym0jsir5	421	59	MAPK	MAPK	NNP
cord-254895-ym0jsir5	421	60	signaling	signal	VBG
cord-254895-ym0jsir5	421	61	pathways	pathway	NNS
cord-254895-ym0jsir5	422	1	Subcellular	subcellular	JJ
cord-254895-ym0jsir5	422	2	localization	localization	NN
cord-254895-ym0jsir5	422	3	of	of	IN
cord-254895-ym0jsir5	422	4	Toll	toll	NN
cord-254895-ym0jsir5	422	5	-	-	HYPH
cord-254895-ym0jsir5	422	6	like	like	JJ
cord-254895-ym0jsir5	422	7	receptor	receptor	NN
cord-254895-ym0jsir5	422	8	3	3	CD
cord-254895-ym0jsir5	422	9	in	in	IN
cord-254895-ym0jsir5	422	10	human	human	JJ
cord-254895-ym0jsir5	422	11	dendritic	dendritic	JJ
cord-254895-ym0jsir5	422	12	cells	cell	NNS
cord-254895-ym0jsir5	422	13	Human	human	JJ
cord-254895-ym0jsir5	422	14	lupus	lupus	NN
cord-254895-ym0jsir5	422	15	autoantibody	autoantibody	NNP
cord-254895-ym0jsir5	422	16	-	-	HYPH
cord-254895-ym0jsir5	422	17	DNA	DNA	NNP
cord-254895-ym0jsir5	422	18	complexes	complex	NNS
cord-254895-ym0jsir5	422	19	activate	activate	VBP
cord-254895-ym0jsir5	422	20	DCs	dc	NNS
cord-254895-ym0jsir5	422	21	through	through	IN
cord-254895-ym0jsir5	422	22	cooperation	cooperation	NN
cord-254895-ym0jsir5	422	23	of	of	IN
cord-254895-ym0jsir5	422	24	CD32	CD32	NNP
cord-254895-ym0jsir5	422	25	and	and	CC
cord-254895-ym0jsir5	422	26	TLR9	TLR9	NNP
cord-254895-ym0jsir5	422	27	RIP1	RIP1	NNP
cord-254895-ym0jsir5	422	28	is	be	VBZ
cord-254895-ym0jsir5	422	29	an	an	DT
cord-254895-ym0jsir5	422	30	essential	essential	JJ
cord-254895-ym0jsir5	422	31	mediator	mediator	NN
cord-254895-ym0jsir5	422	32	of	of	IN
cord-254895-ym0jsir5	422	33	Toll	Toll	NNP
cord-254895-ym0jsir5	422	34	-	-	HYPH
cord-254895-ym0jsir5	422	35	like	like	JJ
cord-254895-ym0jsir5	422	36	receptor	receptor	NN
cord-254895-ym0jsir5	423	1	3-induced	3-induced	CD
cord-254895-ym0jsir5	423	2	NFkappa	NFkappa	NNP
cord-254895-ym0jsir5	423	3	B	B	NNP
cord-254895-ym0jsir5	423	4	activation	activation	NN
cord-254895-ym0jsir5	423	5	Cardif	Cardif	NNP
cord-254895-ym0jsir5	423	6	is	be	VBZ
cord-254895-ym0jsir5	423	7	an	an	DT
cord-254895-ym0jsir5	423	8	adaptor	adaptor	NN
cord-254895-ym0jsir5	423	9	protein	protein	NN
cord-254895-ym0jsir5	423	10	in	in	IN
cord-254895-ym0jsir5	423	11	the	the	DT
cord-254895-ym0jsir5	423	12	RIG	rig	NN
cord-254895-ym0jsir5	423	13	-	-	:
cord-254895-ym0jsir5	423	14	I	I	NNP
cord-254895-ym0jsir5	423	15	antiviral	antiviral	JJ
cord-254895-ym0jsir5	423	16	pathway	pathway	NN
cord-254895-ym0jsir5	423	17	and	and	CC
cord-254895-ym0jsir5	423	18	is	be	VBZ
cord-254895-ym0jsir5	423	19	targeted	target	VBN
cord-254895-ym0jsir5	423	20	by	by	IN
cord-254895-ym0jsir5	423	21	hepatitis	hepatitis	NN
cord-254895-ym0jsir5	423	22	C	C	NNP
cord-254895-ym0jsir5	423	23	virus	virus	NN
cord-254895-ym0jsir5	423	24	Intracellular	Intracellular	NNP
cord-254895-ym0jsir5	423	25	pattern	pattern	NN
cord-254895-ym0jsir5	423	26	recognition	recognition	NN
cord-254895-ym0jsir5	423	27	receptors	receptor	NNS
cord-254895-ym0jsir5	423	28	in	in	IN
cord-254895-ym0jsir5	423	29	the	the	DT
cord-254895-ym0jsir5	423	30	host	host	NN
cord-254895-ym0jsir5	423	31	response	response	NN
cord-254895-ym0jsir5	423	32	Inhibition	inhibition	NN
cord-254895-ym0jsir5	423	33	of	of	IN
cord-254895-ym0jsir5	423	34	retinoic	retinoic	JJ
cord-254895-ym0jsir5	423	35	acid	acid	NN
cord-254895-ym0jsir5	423	36	-	-	HYPH
cord-254895-ym0jsir5	423	37	inducible	inducible	JJ
cord-254895-ym0jsir5	423	38	gene	gene	NN
cord-254895-ym0jsir5	424	1	I	-PRON-	PRP
cord-254895-ym0jsir5	424	2	-	-	HYPH
cord-254895-ym0jsir5	424	3	mediated	mediate	VBN
cord-254895-ym0jsir5	424	4	induction	induction	NN
cord-254895-ym0jsir5	424	5	of	of	IN
cord-254895-ym0jsir5	424	6	beta	beta	NN
cord-254895-ym0jsir5	424	7	interferon	interferon	NN
cord-254895-ym0jsir5	424	8	by	by	IN
cord-254895-ym0jsir5	424	9	the	the	DT
cord-254895-ym0jsir5	424	10	NS1	ns1	NN
cord-254895-ym0jsir5	424	11	protein	protein	NN
cord-254895-ym0jsir5	424	12	of	of	IN
cord-254895-ym0jsir5	424	13	influenza	influenza	NN
cord-254895-ym0jsir5	424	14	A	a	DT
cord-254895-ym0jsir5	424	15	virus	virus	NN
cord-254895-ym0jsir5	424	16	Human	human	JJ
cord-254895-ym0jsir5	424	17	plasmacytoid	plasmacytoid	NN
cord-254895-ym0jsir5	424	18	dendritic	dendritic	JJ
cord-254895-ym0jsir5	424	19	cells	cell	NNS
cord-254895-ym0jsir5	424	20	activated	activate	VBN
cord-254895-ym0jsir5	424	21	by	by	IN
cord-254895-ym0jsir5	424	22	CpG	CpG	NNP
cord-254895-ym0jsir5	424	23	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-254895-ym0jsir5	424	24	induce	induce	VBP
cord-254895-ym0jsir5	424	25	the	the	DT
cord-254895-ym0jsir5	424	26	generation	generation	NN
cord-254895-ym0jsir5	424	27	of	of	IN
cord-254895-ym0jsir5	424	28	CD4+CD25	cd4+cd25	NN
cord-254895-ym0jsir5	424	29	+	+	CC
cord-254895-ym0jsir5	425	1	regulatory	regulatory	JJ
cord-254895-ym0jsir5	425	2	T	T	NNP
cord-254895-ym0jsir5	425	3	cells	cell	NNS
cord-254895-ym0jsir5	425	4	Evidence	evidence	NN
cord-254895-ym0jsir5	425	5	for	for	IN
cord-254895-ym0jsir5	425	6	licensing	licensing	NN
cord-254895-ym0jsir5	425	7	of	of	IN
cord-254895-ym0jsir5	425	8	IFNgamma	IFNgamma	NNP
cord-254895-ym0jsir5	425	9	-	-	HYPH
cord-254895-ym0jsir5	425	10	induced	induce	VBN
cord-254895-ym0jsir5	425	11	IFN	IFN	NNP
cord-254895-ym0jsir5	425	12	regulatory	regulatory	JJ
cord-254895-ym0jsir5	425	13	factor	factor	NN
cord-254895-ym0jsir5	425	14	1	1	CD
cord-254895-ym0jsir5	425	15	transcription	transcription	NN
cord-254895-ym0jsir5	425	16	factor	factor	NN
cord-254895-ym0jsir5	425	17	by	by	IN
cord-254895-ym0jsir5	425	18	MyD88	MyD88	NNS
cord-254895-ym0jsir5	425	19	in	in	IN
cord-254895-ym0jsir5	425	20	Toll	Toll	NNP
cord-254895-ym0jsir5	425	21	-	-	HYPH
cord-254895-ym0jsir5	425	22	like	like	JJ
cord-254895-ym0jsir5	425	23	receptor	receptor	NN
cord-254895-ym0jsir5	425	24	-	-	HYPH
cord-254895-ym0jsir5	425	25	dependent	dependent	JJ
cord-254895-ym0jsir5	425	26	gene	gene	NN
cord-254895-ym0jsir5	425	27	induction	induction	NN
cord-254895-ym0jsir5	425	28	program	program	NN
cord-254895-ym0jsir5	426	1	An	an	DT
cord-254895-ym0jsir5	426	2	absolute	absolute	JJ
cord-254895-ym0jsir5	426	3	and	and	CC
cord-254895-ym0jsir5	426	4	restricted	restricted	JJ
cord-254895-ym0jsir5	426	5	requirement	requirement	NN
cord-254895-ym0jsir5	426	6	for	for	IN
cord-254895-ym0jsir5	426	7	IL-12	IL-12	NNP
cord-254895-ym0jsir5	426	8	in	in	IN
cord-254895-ym0jsir5	426	9	natural	natural	JJ
cord-254895-ym0jsir5	426	10	killer	killer	NN
cord-254895-ym0jsir5	426	11	cell	cell	NN
cord-254895-ym0jsir5	426	12	IFN	IFN	NNP
cord-254895-ym0jsir5	426	13	-	-	HYPH
cord-254895-ym0jsir5	426	14	gamma	gamma	NN
cord-254895-ym0jsir5	426	15	production	production	NN
cord-254895-ym0jsir5	426	16	and	and	CC
cord-254895-ym0jsir5	426	17	antiviral	antiviral	JJ
cord-254895-ym0jsir5	426	18	defense	defense	NN
cord-254895-ym0jsir5	426	19	.	.	.
cord-254895-ym0jsir5	427	1	Studies	study	NNS
cord-254895-ym0jsir5	427	2	of	of	IN
cord-254895-ym0jsir5	427	3	natural	natural	JJ
cord-254895-ym0jsir5	427	4	killer	killer	NN
cord-254895-ym0jsir5	427	5	and	and	CC
cord-254895-ym0jsir5	427	6	T	T	NNP
cord-254895-ym0jsir5	427	7	cell	cell	NN
cord-254895-ym0jsir5	427	8	responses	response	NNS
cord-254895-ym0jsir5	427	9	in	in	IN
cord-254895-ym0jsir5	427	10	contrasting	contrast	VBG
cord-254895-ym0jsir5	427	11	viral	viral	JJ
cord-254895-ym0jsir5	427	12	infections	infection	NNS
cord-254895-ym0jsir5	427	13	Characterization	characterization	NN
cord-254895-ym0jsir5	427	14	of	of	IN
cord-254895-ym0jsir5	427	15	early	early	JJ
cord-254895-ym0jsir5	427	16	IL-12	IL-12	NNP
cord-254895-ym0jsir5	427	17	,	,	,
cord-254895-ym0jsir5	427	18	IFN	IFN	NNP
cord-254895-ym0jsir5	427	19	-	-	HYPH
cord-254895-ym0jsir5	427	20	alphabeta	alphabeta	NNP
cord-254895-ym0jsir5	427	21	,	,	,
cord-254895-ym0jsir5	427	22	and	and	CC
cord-254895-ym0jsir5	427	23	TNF	TNF	NNP
cord-254895-ym0jsir5	427	24	effects	effect	NNS
cord-254895-ym0jsir5	427	25	on	on	IN
cord-254895-ym0jsir5	427	26	antiviral	antiviral	JJ
cord-254895-ym0jsir5	427	27	state	state	NN
cord-254895-ym0jsir5	427	28	and	and	CC
cord-254895-ym0jsir5	427	29	NK	NK	NNP
cord-254895-ym0jsir5	427	30	cell	cell	NN
cord-254895-ym0jsir5	427	31	responses	response	NNS
cord-254895-ym0jsir5	427	32	during	during	IN
cord-254895-ym0jsir5	427	33	murine	murine	JJ
cord-254895-ym0jsir5	427	34	cytomegalovirus	cytomegalovirus	NN
cord-254895-ym0jsir5	427	35	infection	infection	NN
cord-254895-ym0jsir5	428	1	A	a	DT
cord-254895-ym0jsir5	428	2	leukocyte	leukocyte	NN
cord-254895-ym0jsir5	428	3	subset	subset	VBN
cord-254895-ym0jsir5	428	4	bearing	bear	VBG
cord-254895-ym0jsir5	428	5	HLA	HLA	NNP
cord-254895-ym0jsir5	428	6	-	-	HYPH
cord-254895-ym0jsir5	428	7	DR	DR	NNP
cord-254895-ym0jsir5	428	8	antigens	antigen	NNS
cord-254895-ym0jsir5	428	9	is	be	VBZ
cord-254895-ym0jsir5	428	10	responsible	responsible	JJ
cord-254895-ym0jsir5	428	11	for	for	IN
cord-254895-ym0jsir5	428	12	in	in	FW
cord-254895-ym0jsir5	428	13	vitro	vitro	FW
cord-254895-ym0jsir5	428	14	alpha	alpha	NN
cord-254895-ym0jsir5	428	15	interferon	interferon	NN
cord-254895-ym0jsir5	428	16	production	production	NN
cord-254895-ym0jsir5	428	17	in	in	IN
cord-254895-ym0jsir5	428	18	response	response	NN
cord-254895-ym0jsir5	428	19	to	to	IN
cord-254895-ym0jsir5	428	20	viruses	virus	NNS
cord-254895-ym0jsir5	428	21	RIG	rig	VB
cord-254895-ym0jsir5	428	22	-	-	HYPH
cord-254895-ym0jsir5	428	23	I	i	NN
cord-254895-ym0jsir5	428	24	-	-	HYPH
cord-254895-ym0jsir5	428	25	mediated	mediate	VBN
cord-254895-ym0jsir5	428	26	antiviral	antiviral	JJ
cord-254895-ym0jsir5	428	27	responses	response	NNS
cord-254895-ym0jsir5	428	28	to	to	IN
cord-254895-ym0jsir5	428	29	single	single	RB
cord-254895-ym0jsir5	428	30	-	-	HYPH
cord-254895-ym0jsir5	428	31	stranded	strand	VBN
cord-254895-ym0jsir5	428	32	RNA	RNA	NNP
cord-254895-ym0jsir5	428	33	bearing	bear	VBG
cord-254895-ym0jsir5	428	34	5	5	CD
cord-254895-ym0jsir5	428	35	0	0	CD
cord-254895-ym0jsir5	429	1	-phosphates	-phosphates	:
cord-254895-ym0jsir5	429	2	Properties	Properties	NNP
cord-254895-ym0jsir5	429	3	of	of	IN
cord-254895-ym0jsir5	429	4	human	human	JJ
cord-254895-ym0jsir5	429	5	natural	natural	JJ
cord-254895-ym0jsir5	429	6	interferon	interferon	NN
cord-254895-ym0jsir5	429	7	-	-	HYPH
cord-254895-ym0jsir5	429	8	producing	produce	VBG
cord-254895-ym0jsir5	429	9	cells	cell	NNS
cord-254895-ym0jsir5	429	10	stimulated	stimulate	VBN
cord-254895-ym0jsir5	429	11	by	by	IN
cord-254895-ym0jsir5	429	12	tumor	tumor	NN
cord-254895-ym0jsir5	429	13	cell	cell	NN
cord-254895-ym0jsir5	429	14	lines	line	NNS
cord-254895-ym0jsir5	430	1	The	the	DT
cord-254895-ym0jsir5	430	2	RNA	RNA	NNP
cord-254895-ym0jsir5	430	3	helicase	helicase	NN
cord-254895-ym0jsir5	430	4	Lgp2	Lgp2	NNP
cord-254895-ym0jsir5	430	5	inhibits	inhibit	VBZ
cord-254895-ym0jsir5	430	6	TLR	TLR	NNP
cord-254895-ym0jsir5	430	7	-	-	HYPH
cord-254895-ym0jsir5	430	8	independent	independent	JJ
cord-254895-ym0jsir5	430	9	sensing	sensing	NN
cord-254895-ym0jsir5	430	10	of	of	IN
cord-254895-ym0jsir5	430	11	viral	viral	JJ
cord-254895-ym0jsir5	430	12	replication	replication	NN
cord-254895-ym0jsir5	430	13	by	by	IN
cord-254895-ym0jsir5	430	14	retinoic	retinoic	JJ
cord-254895-ym0jsir5	430	15	acid	acid	NN
cord-254895-ym0jsir5	430	16	-	-	HYPH
cord-254895-ym0jsir5	430	17	inducible	inducible	JJ
cord-254895-ym0jsir5	430	18	gene	gene	NN
cord-254895-ym0jsir5	430	19	-	-	:
cord-254895-ym0jsir5	430	20	I	I	NNP
cord-254895-ym0jsir5	430	21	Deletion	deletion	NN
cord-254895-ym0jsir5	430	22	of	of	IN
cord-254895-ym0jsir5	430	23	TLR3	TLR3	NNP
cord-254895-ym0jsir5	430	24	alters	alter	VBZ
cord-254895-ym0jsir5	430	25	the	the	DT
cord-254895-ym0jsir5	430	26	pulmonary	pulmonary	JJ
cord-254895-ym0jsir5	430	27	immune	immune	JJ
cord-254895-ym0jsir5	430	28	environment	environment	NN
cord-254895-ym0jsir5	430	29	and	and	CC
cord-254895-ym0jsir5	430	30	mucus	mucus	NN
cord-254895-ym0jsir5	430	31	production	production	NN
cord-254895-ym0jsir5	430	32	during	during	IN
cord-254895-ym0jsir5	430	33	respiratory	respiratory	JJ
cord-254895-ym0jsir5	430	34	syncytial	syncytial	JJ
cord-254895-ym0jsir5	430	35	virus	virus	NN
cord-254895-ym0jsir5	430	36	infection	infection	NN
cord-254895-ym0jsir5	430	37	Regulation	regulation	NN
cord-254895-ym0jsir5	430	38	of	of	IN
cord-254895-ym0jsir5	430	39	antiviral	antiviral	JJ
cord-254895-ym0jsir5	430	40	responses	response	NNS
cord-254895-ym0jsir5	430	41	by	by	IN
cord-254895-ym0jsir5	430	42	a	a	DT
cord-254895-ym0jsir5	430	43	direct	direct	JJ
cord-254895-ym0jsir5	430	44	and	and	CC
cord-254895-ym0jsir5	430	45	specific	specific	JJ
cord-254895-ym0jsir5	430	46	interaction	interaction	NN
cord-254895-ym0jsir5	430	47	between	between	IN
cord-254895-ym0jsir5	430	48	TRAF3	traf3	NN
cord-254895-ym0jsir5	430	49	and	and	CC
cord-254895-ym0jsir5	430	50	Cardif	Cardif	NNP
cord-254895-ym0jsir5	430	51	Regulation	Regulation	NNP
cord-254895-ym0jsir5	430	52	of	of	IN
cord-254895-ym0jsir5	430	53	innate	innate	JJ
cord-254895-ym0jsir5	430	54	antiviral	antiviral	JJ
cord-254895-ym0jsir5	430	55	defenses	defense	NNS
cord-254895-ym0jsir5	430	56	through	through	IN
cord-254895-ym0jsir5	430	57	a	a	DT
cord-254895-ym0jsir5	430	58	shared	share	VBN
cord-254895-ym0jsir5	430	59	repressor	repressor	NN
cord-254895-ym0jsir5	430	60	domain	domain	NN
cord-254895-ym0jsir5	430	61	in	in	IN
cord-254895-ym0jsir5	430	62	RIG	rig	NN
cord-254895-ym0jsir5	430	63	-	-	:
cord-254895-ym0jsir5	430	64	I	I	NNP
cord-254895-ym0jsir5	430	65	and	and	CC
cord-254895-ym0jsir5	430	66	LGP2	LGP2	NNP
cord-254895-ym0jsir5	430	67	CpG	CpG	NNP
cord-254895-ym0jsir5	430	68	-	-	HYPH
cord-254895-ym0jsir5	430	69	matured	mature	VBN
cord-254895-ym0jsir5	430	70	murine	murine	JJ
cord-254895-ym0jsir5	430	71	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	430	72	dendritic	dendritic	JJ
cord-254895-ym0jsir5	430	73	cells	cell	NNS
cord-254895-ym0jsir5	430	74	are	be	VBP
cord-254895-ym0jsir5	430	75	capable	capable	JJ
cord-254895-ym0jsir5	430	76	of	of	IN
cord-254895-ym0jsir5	430	77	in	in	IN
cord-254895-ym0jsir5	430	78	vivo	vivo	FW
cord-254895-ym0jsir5	430	79	priming	priming	NN
cord-254895-ym0jsir5	430	80	of	of	IN
cord-254895-ym0jsir5	430	81	functional	functional	JJ
cord-254895-ym0jsir5	430	82	CD8	CD8	NNP
cord-254895-ym0jsir5	430	83	T	T	NNP
cord-254895-ym0jsir5	430	84	cell	cell	NN
cord-254895-ym0jsir5	430	85	responses	response	NNS
cord-254895-ym0jsir5	430	86	to	to	IN
cord-254895-ym0jsir5	430	87	endogenous	endogenous	JJ
cord-254895-ym0jsir5	430	88	but	but	CC
cord-254895-ym0jsir5	430	89	not	not	RB
cord-254895-ym0jsir5	430	90	exogenous	exogenous	JJ
cord-254895-ym0jsir5	430	91	antigens	antigen	NNS
cord-254895-ym0jsir5	430	92	Toll	Toll	NNP
cord-254895-ym0jsir5	430	93	/	/	SYM
cord-254895-ym0jsir5	430	94	IL-1	IL-1	NNP
cord-254895-ym0jsir5	430	95	receptor	receptor	NN
cord-254895-ym0jsir5	430	96	domain	domain	NN
cord-254895-ym0jsir5	430	97	-	-	HYPH
cord-254895-ym0jsir5	430	98	containing	contain	VBG
cord-254895-ym0jsir5	430	99	adaptor	adaptor	NN
cord-254895-ym0jsir5	430	100	inducing	induce	VBG
cord-254895-ym0jsir5	430	101	IFN	IFN	NNP
cord-254895-ym0jsir5	430	102	-	-	HYPH
cord-254895-ym0jsir5	430	103	beta	beta	NN
cord-254895-ym0jsir5	430	104	(	(	-LRB-
cord-254895-ym0jsir5	430	105	TRIF	TRIF	NNP
cord-254895-ym0jsir5	430	106	)	)	-RRB-
cord-254895-ym0jsir5	430	107	associates	associate	NNS
cord-254895-ym0jsir5	430	108	with	with	IN
cord-254895-ym0jsir5	430	109	TNF	TNF	NNP
cord-254895-ym0jsir5	430	110	receptor	receptor	NN
cord-254895-ym0jsir5	430	111	-	-	HYPH
cord-254895-ym0jsir5	430	112	associated	associate	VBN
cord-254895-ym0jsir5	430	113	factor	factor	NN
cord-254895-ym0jsir5	430	114	6	6	CD
cord-254895-ym0jsir5	430	115	and	and	CC
cord-254895-ym0jsir5	430	116	TANK	tank	NN
cord-254895-ym0jsir5	430	117	-	-	HYPH
cord-254895-ym0jsir5	430	118	binding	bind	VBG
cord-254895-ym0jsir5	430	119	kinase	kinase	NN
cord-254895-ym0jsir5	430	120	1	1	CD
cord-254895-ym0jsir5	430	121	,	,	,
cord-254895-ym0jsir5	430	122	and	and	CC
cord-254895-ym0jsir5	430	123	activates	activate	VBZ
cord-254895-ym0jsir5	430	124	two	two	CD
cord-254895-ym0jsir5	430	125	distinct	distinct	JJ
cord-254895-ym0jsir5	430	126	transcription	transcription	NN
cord-254895-ym0jsir5	430	127	factors	factor	NNS
cord-254895-ym0jsir5	430	128	,	,	,
cord-254895-ym0jsir5	430	129	NF	nf	NN
cord-254895-ym0jsir5	430	130	-	-	HYPH
cord-254895-ym0jsir5	430	131	kappa	kappa	NN
cord-254895-ym0jsir5	430	132	B	B	NNP
cord-254895-ym0jsir5	430	133	and	and	CC
cord-254895-ym0jsir5	430	134	IFN	IFN	NNP
cord-254895-ym0jsir5	430	135	-	-	HYPH
cord-254895-ym0jsir5	430	136	regulatory	regulatory	JJ
cord-254895-ym0jsir5	430	137	factor-3	factor-3	NNP
cord-254895-ym0jsir5	430	138	,	,	,
cord-254895-ym0jsir5	430	139	in	in	IN
cord-254895-ym0jsir5	430	140	the	the	DT
cord-254895-ym0jsir5	430	141	Toll	Toll	NNP
cord-254895-ym0jsir5	430	142	-	-	HYPH
cord-254895-ym0jsir5	430	143	like	like	JJ
cord-254895-ym0jsir5	430	144	receptor	receptor	NN
cord-254895-ym0jsir5	430	145	signaling	signal	VBG
cord-254895-ym0jsir5	430	146	Murine	Murine	NNP
cord-254895-ym0jsir5	430	147	plasmacytoid	plasmacytoid	NN
cord-254895-ym0jsir5	430	148	dendritic	dendritic	JJ
cord-254895-ym0jsir5	430	149	cells	cell	NNS
cord-254895-ym0jsir5	430	150	induce	induce	VBP
cord-254895-ym0jsir5	430	151	effector	effector	NN
cord-254895-ym0jsir5	430	152	/	/	SYM
cord-254895-ym0jsir5	430	153	memory	memory	NN
cord-254895-ym0jsir5	430	154	CD8	CD8	NNP
cord-254895-ym0jsir5	430	155	+	+	CC
cord-254895-ym0jsir5	430	156	T	t	NN
cord-254895-ym0jsir5	430	157	-	-	HYPH
cord-254895-ym0jsir5	430	158	cell	cell	NN
cord-254895-ym0jsir5	430	159	responses	response	NNS
cord-254895-ym0jsir5	430	160	in	in	IN
cord-254895-ym0jsir5	430	161	vivo	vivo	NN
cord-254895-ym0jsir5	430	162	after	after	IN
cord-254895-ym0jsir5	430	163	viral	viral	JJ
cord-254895-ym0jsir5	430	164	stimulation	stimulation	NN
cord-254895-ym0jsir5	431	1	Interferon	interferon	NN
cord-254895-ym0jsir5	431	2	-	-	HYPH
cord-254895-ym0jsir5	431	3	regulatory	regulatory	JJ
cord-254895-ym0jsir5	431	4	-	-	HYPH
cord-254895-ym0jsir5	431	5	factor	factor	NN
cord-254895-ym0jsir5	431	6	1	1	CD
cord-254895-ym0jsir5	431	7	controls	control	NNS
cord-254895-ym0jsir5	432	1	Toll	toll	NN
cord-254895-ym0jsir5	432	2	-	-	HYPH
cord-254895-ym0jsir5	432	3	like	like	JJ
cord-254895-ym0jsir5	432	4	receptor	receptor	NN
cord-254895-ym0jsir5	432	5	9-mediated	9-mediated	CD
cord-254895-ym0jsir5	432	6	IFN	IFN	NNP
cord-254895-ym0jsir5	432	7	-	-	HYPH
cord-254895-ym0jsir5	432	8	beta	beta	NN
cord-254895-ym0jsir5	432	9	production	production	NN
cord-254895-ym0jsir5	432	10	in	in	IN
cord-254895-ym0jsir5	432	11	myeloid	myeloid	JJ
cord-254895-ym0jsir5	432	12	dendritic	dendritic	JJ
cord-254895-ym0jsir5	432	13	cells	cell	NNS
cord-254895-ym0jsir5	432	14	Toll	Toll	NNP
cord-254895-ym0jsir5	432	15	-	-	HYPH
cord-254895-ym0jsir5	432	16	like	like	JJ
cord-254895-ym0jsir5	432	17	receptor	receptor	NN
cord-254895-ym0jsir5	432	18	3	3	CD
cord-254895-ym0jsir5	432	19	promotes	promote	VBZ
cord-254895-ym0jsir5	432	20	cross	cross	NN
cord-254895-ym0jsir5	432	21	-	-	JJ
cord-254895-ym0jsir5	432	22	priming	priming	NN
cord-254895-ym0jsir5	432	23	to	to	IN
cord-254895-ym0jsir5	432	24	virus	virus	NN
cord-254895-ym0jsir5	432	25	-	-	HYPH
cord-254895-ym0jsir5	432	26	infected	infect	VBN
cord-254895-ym0jsir5	432	27	cells	cell	NNS
cord-254895-ym0jsir5	432	28	Identification	identification	NN
cord-254895-ym0jsir5	432	29	and	and	CC
cord-254895-ym0jsir5	432	30	characterization	characterization	NN
cord-254895-ym0jsir5	432	31	of	of	IN
cord-254895-ym0jsir5	432	32	MAVS	MAVS	NNPS
cord-254895-ym0jsir5	432	33	,	,	,
cord-254895-ym0jsir5	432	34	a	a	DT
cord-254895-ym0jsir5	432	35	mitochondrial	mitochondrial	JJ
cord-254895-ym0jsir5	432	36	antiviral	antiviral	JJ
cord-254895-ym0jsir5	432	37	signaling	signal	VBG
cord-254895-ym0jsir5	432	38	protein	protein	NN
cord-254895-ym0jsir5	432	39	that	that	WDT
cord-254895-ym0jsir5	432	40	activates	activate	VBZ
cord-254895-ym0jsir5	432	41	NF	NF	NNP
cord-254895-ym0jsir5	432	42	-	-	HYPH
cord-254895-ym0jsir5	432	43	kappaB	kappaB	NNP
cord-254895-ym0jsir5	432	44	and	and	CC
cord-254895-ym0jsir5	432	45	IRF	IRF	NNP
cord-254895-ym0jsir5	432	46	3	3	CD
cord-254895-ym0jsir5	432	47	Triggering	trigger	VBG
cord-254895-ym0jsir5	432	48	the	the	DT
cord-254895-ym0jsir5	432	49	interferon	interferon	NN
cord-254895-ym0jsir5	432	50	antiviral	antiviral	JJ
cord-254895-ym0jsir5	432	51	response	response	NN
cord-254895-ym0jsir5	432	52	through	through	IN
cord-254895-ym0jsir5	432	53	an	an	DT
cord-254895-ym0jsir5	432	54	IKK	IKK	NNP
cord-254895-ym0jsir5	432	55	-	-	HYPH
cord-254895-ym0jsir5	432	56	related	relate	VBN
cord-254895-ym0jsir5	432	57	pathway	pathway	NN
cord-254895-ym0jsir5	432	58	Osteopontin	Osteopontin	NNP
cord-254895-ym0jsir5	432	59	expression	expression	NN
cord-254895-ym0jsir5	432	60	is	be	VBZ
cord-254895-ym0jsir5	432	61	essential	essential	JJ
cord-254895-ym0jsir5	432	62	for	for	IN
cord-254895-ym0jsir5	432	63	interferon	interferon	NN
cord-254895-ym0jsir5	432	64	-	-	HYPH
cord-254895-ym0jsir5	432	65	alpha	alpha	NN
cord-254895-ym0jsir5	432	66	production	production	NN
cord-254895-ym0jsir5	432	67	by	by	IN
cord-254895-ym0jsir5	432	68	plasmacytoid	plasmacytoid	NNP
cord-254895-ym0jsir5	432	69	dendritic	dendritic	JJ
cord-254895-ym0jsir5	432	70	cells	cell	NNS
cord-254895-ym0jsir5	433	1	The	the	DT
cord-254895-ym0jsir5	433	2	nature	nature	NN
cord-254895-ym0jsir5	433	3	of	of	IN
cord-254895-ym0jsir5	433	4	the	the	DT
cord-254895-ym0jsir5	433	5	principal	principal	JJ
cord-254895-ym0jsir5	433	6	type	type	NN
cord-254895-ym0jsir5	433	7	1	1	CD
cord-254895-ym0jsir5	433	8	interferon	interferon	NN
cord-254895-ym0jsir5	433	9	-	-	HYPH
cord-254895-ym0jsir5	433	10	producing	produce	VBG
cord-254895-ym0jsir5	433	11	cells	cell	NNS
cord-254895-ym0jsir5	433	12	in	in	IN
cord-254895-ym0jsir5	433	13	human	human	JJ
cord-254895-ym0jsir5	433	14	blood	blood	NN
cord-254895-ym0jsir5	433	15	Recognition	Recognition	NNP
cord-254895-ym0jsir5	433	16	of	of	IN
cord-254895-ym0jsir5	433	17	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	433	18	DNA	dna	NN
cord-254895-ym0jsir5	433	19	activates	activate	VBZ
cord-254895-ym0jsir5	433	20	an	an	DT
cord-254895-ym0jsir5	433	21	IRF3-dependent	irf3-dependent	NN
cord-254895-ym0jsir5	433	22	innate	innate	JJ
cord-254895-ym0jsir5	433	23	immune	immune	JJ
cord-254895-ym0jsir5	433	24	response	response	NN
cord-254895-ym0jsir5	433	25	Regulating	regulate	VBG
cord-254895-ym0jsir5	433	26	intracellular	intracellular	JJ
cord-254895-ym0jsir5	433	27	antiviral	antiviral	JJ
cord-254895-ym0jsir5	433	28	defense	defense	NN
cord-254895-ym0jsir5	433	29	and	and	CC
cord-254895-ym0jsir5	433	30	permissiveness	permissiveness	NN
cord-254895-ym0jsir5	433	31	to	to	IN
cord-254895-ym0jsir5	433	32	hepatitis	hepatitis	NNP
cord-254895-ym0jsir5	433	33	C	C	NNP
cord-254895-ym0jsir5	433	34	virus	virus	NN
cord-254895-ym0jsir5	433	35	RNA	RNA	NNP
cord-254895-ym0jsir5	433	36	replication	replication	NN
cord-254895-ym0jsir5	433	37	through	through	IN
cord-254895-ym0jsir5	433	38	a	a	DT
cord-254895-ym0jsir5	433	39	cellular	cellular	JJ
cord-254895-ym0jsir5	433	40	RNA	rna	NN
cord-254895-ym0jsir5	433	41	helicase	helicase	NN
cord-254895-ym0jsir5	433	42	,	,	,
cord-254895-ym0jsir5	433	43	RIG-	RIG-	NNP
cord-254895-ym0jsir5	434	1	I	-PRON-	PRP
cord-254895-ym0jsir5	435	1	The	the	DT
cord-254895-ym0jsir5	435	2	specific	specific	JJ
cord-254895-ym0jsir5	435	3	and	and	CC
cord-254895-ym0jsir5	435	4	essential	essential	JJ
cord-254895-ym0jsir5	435	5	role	role	NN
cord-254895-ym0jsir5	435	6	of	of	IN
cord-254895-ym0jsir5	435	7	MAVS	MAVS	NNPS
cord-254895-ym0jsir5	435	8	in	in	IN
cord-254895-ym0jsir5	435	9	antiviral	antiviral	JJ
cord-254895-ym0jsir5	435	10	innate	innate	JJ
cord-254895-ym0jsir5	435	11	immune	immune	JJ
cord-254895-ym0jsir5	435	12	responses	response	NNS
cord-254895-ym0jsir5	435	13	Toll	toll	NN
cord-254895-ym0jsir5	435	14	-	-	HYPH
cord-254895-ym0jsir5	435	15	like	like	JJ
cord-254895-ym0jsir5	435	16	receptors	receptor	NNS
cord-254895-ym0jsir5	435	17	9	9	CD
cord-254895-ym0jsir5	435	18	and	and	CC
cord-254895-ym0jsir5	435	19	3	3	CD
cord-254895-ym0jsir5	435	20	as	as	IN
cord-254895-ym0jsir5	435	21	essential	essential	JJ
cord-254895-ym0jsir5	435	22	components	component	NNS
cord-254895-ym0jsir5	435	23	of	of	IN
cord-254895-ym0jsir5	435	24	innate	innate	JJ
cord-254895-ym0jsir5	435	25	immune	immune	JJ
cord-254895-ym0jsir5	435	26	defense	defense	NN
cord-254895-ym0jsir5	435	27	against	against	IN
cord-254895-ym0jsir5	435	28	mouse	mouse	NN
cord-254895-ym0jsir5	435	29	cytomegalovirus	cytomegalovirus	NNP
cord-254895-ym0jsir5	435	30	infection	infection	NN
cord-254895-ym0jsir5	436	1	The	the	DT
cord-254895-ym0jsir5	436	2	Unc93b1	unc93b1	NN
cord-254895-ym0jsir5	436	3	mutation	mutation	NN
cord-254895-ym0jsir5	436	4	3d	3d	NNP
cord-254895-ym0jsir5	436	5	disrupts	disrupt	VBZ
cord-254895-ym0jsir5	436	6	exogenous	exogenous	JJ
cord-254895-ym0jsir5	436	7	antigen	antigen	NN
cord-254895-ym0jsir5	436	8	presentation	presentation	NN
cord-254895-ym0jsir5	436	9	and	and	CC
cord-254895-ym0jsir5	436	10	signaling	signal	VBG
cord-254895-ym0jsir5	436	11	via	via	IN
cord-254895-ym0jsir5	436	12	Toll	toll	NN
cord-254895-ym0jsir5	436	13	-	-	HYPH
cord-254895-ym0jsir5	436	14	like	like	JJ
cord-254895-ym0jsir5	436	15	receptors	receptor	NNS
cord-254895-ym0jsir5	436	16	3	3	CD
cord-254895-ym0jsir5	436	17	,	,	,
cord-254895-ym0jsir5	436	18	7	7	CD
cord-254895-ym0jsir5	436	19	and	and	CC
cord-254895-ym0jsir5	436	20	9	9	CD
cord-254895-ym0jsir5	436	21	DAI	DAI	NNP
cord-254895-ym0jsir5	436	22	(	(	-LRB-
cord-254895-ym0jsir5	436	23	DLM-1	DLM-1	NNP
cord-254895-ym0jsir5	436	24	/	/	SYM
cord-254895-ym0jsir5	436	25	ZBP1	ZBP1	NNP
cord-254895-ym0jsir5	436	26	)	)	-RRB-
cord-254895-ym0jsir5	436	27	is	be	VBZ
cord-254895-ym0jsir5	436	28	a	a	DT
cord-254895-ym0jsir5	436	29	cytosolic	cytosolic	JJ
cord-254895-ym0jsir5	436	30	DNA	dna	NN
cord-254895-ym0jsir5	436	31	sensor	sensor	NN
cord-254895-ym0jsir5	436	32	and	and	CC
cord-254895-ym0jsir5	436	33	an	an	DT
cord-254895-ym0jsir5	436	34	activator	activator	NN
cord-254895-ym0jsir5	436	35	of	of	IN
cord-254895-ym0jsir5	436	36	innate	innate	JJ
cord-254895-ym0jsir5	436	37	immune	immune	JJ
cord-254895-ym0jsir5	436	38	response	response	NN
cord-254895-ym0jsir5	436	39	Activation	Activation	NNP
cord-254895-ym0jsir5	436	40	of	of	IN
cord-254895-ym0jsir5	436	41	interferon	interferon	NN
cord-254895-ym0jsir5	436	42	regulatory	regulatory	JJ
cord-254895-ym0jsir5	436	43	factor	factor	NN
cord-254895-ym0jsir5	436	44	3	3	CD
cord-254895-ym0jsir5	436	45	is	be	VBZ
cord-254895-ym0jsir5	436	46	inhibited	inhibit	VBN
cord-254895-ym0jsir5	436	47	by	by	IN
cord-254895-ym0jsir5	436	48	the	the	DT
cord-254895-ym0jsir5	436	49	influenza	influenza	NN
cord-254895-ym0jsir5	436	50	A	a	DT
cord-254895-ym0jsir5	436	51	virus	virus	NN
cord-254895-ym0jsir5	436	52	NS1	ns1	NN
cord-254895-ym0jsir5	436	53	protein	protein	NN
cord-254895-ym0jsir5	436	54	Interleukin-1	Interleukin-1	NNP
cord-254895-ym0jsir5	436	55	receptorassociated	receptorassociate	VBD
cord-254895-ym0jsir5	436	56	kinase-1	kinase-1	NNP
cord-254895-ym0jsir5	436	57	plays	play	VBZ
cord-254895-ym0jsir5	436	58	an	an	DT
cord-254895-ym0jsir5	436	59	essential	essential	JJ
cord-254895-ym0jsir5	436	60	role	role	NN
cord-254895-ym0jsir5	436	61	for	for	IN
cord-254895-ym0jsir5	436	62	Toll	toll	NN
cord-254895-ym0jsir5	436	63	-	-	HYPH
cord-254895-ym0jsir5	436	64	like	like	JJ
cord-254895-ym0jsir5	436	65	receptor	receptor	NN
cord-254895-ym0jsir5	436	66	(	(	-LRB-
cord-254895-ym0jsir5	436	67	TLR)7-and	tlr)7-and	JJ
cord-254895-ym0jsir5	436	68	TLR9-mediated	tlr9-mediated	JJ
cord-254895-ym0jsir5	436	69	interferon-{alpha	interferon-{alpha	NN
cord-254895-ym0jsir5	436	70	}	}	-RRB-
cord-254895-ym0jsir5	436	71	induction	induction	NN
cord-254895-ym0jsir5	436	72	Human	human	JJ
cord-254895-ym0jsir5	436	73	peripheral	peripheral	JJ
cord-254895-ym0jsir5	436	74	blood	blood	NN
cord-254895-ym0jsir5	436	75	cells	cell	NNS
cord-254895-ym0jsir5	436	76	differentially	differentially	RB
cord-254895-ym0jsir5	436	77	recognize	recognize	VBP
cord-254895-ym0jsir5	436	78	and	and	CC
cord-254895-ym0jsir5	436	79	respond	respond	VB
cord-254895-ym0jsir5	436	80	to	to	IN
cord-254895-ym0jsir5	436	81	two	two	CD
cord-254895-ym0jsir5	436	82	distinct	distinct	JJ
cord-254895-ym0jsir5	436	83	CPG	CPG	NNP
cord-254895-ym0jsir5	436	84	motifs	motif	NNS
cord-254895-ym0jsir5	436	85	Toll	toll	NN
cord-254895-ym0jsir5	436	86	-	-	HYPH
cord-254895-ym0jsir5	436	87	like	like	JJ
cord-254895-ym0jsir5	436	88	receptor	receptor	NN
cord-254895-ym0jsir5	436	89	3	3	CD
cord-254895-ym0jsir5	437	1	mediates	mediate	VBZ
cord-254895-ym0jsir5	437	2	West	West	NNP
cord-254895-ym0jsir5	437	3	Nile	Nile	NNP
cord-254895-ym0jsir5	437	4	virus	virus	NN
cord-254895-ym0jsir5	437	5	entry	entry	NN
cord-254895-ym0jsir5	437	6	into	into	IN
cord-254895-ym0jsir5	437	7	the	the	DT
cord-254895-ym0jsir5	437	8	brain	brain	NN
cord-254895-ym0jsir5	437	9	causing	cause	VBG
cord-254895-ym0jsir5	437	10	lethal	lethal	JJ
cord-254895-ym0jsir5	437	11	encephalitis	encephalitis	NN
cord-254895-ym0jsir5	437	12	VISA	VISA	NNP
cord-254895-ym0jsir5	438	1	is	be	VBZ
cord-254895-ym0jsir5	438	2	an	an	DT
cord-254895-ym0jsir5	438	3	adapter	adapter	NN
cord-254895-ym0jsir5	438	4	protein	protein	NN
cord-254895-ym0jsir5	438	5	required	require	VBN
cord-254895-ym0jsir5	438	6	for	for	IN
cord-254895-ym0jsir5	438	7	virus	virus	NN
cord-254895-ym0jsir5	438	8	-	-	HYPH
cord-254895-ym0jsir5	438	9	triggered	trigger	VBN
cord-254895-ym0jsir5	438	10	IFN	IFN	NNP
cord-254895-ym0jsir5	438	11	-	-	HYPH
cord-254895-ym0jsir5	438	12	beta	beta	NN
cord-254895-ym0jsir5	438	13	signaling	signal	VBG
cord-254895-ym0jsir5	438	14	Role	role	NN
cord-254895-ym0jsir5	438	15	of	of	IN
cord-254895-ym0jsir5	438	16	adaptor	adaptor	NN
cord-254895-ym0jsir5	438	17	TRIF	TRIF	NNP
cord-254895-ym0jsir5	438	18	in	in	IN
cord-254895-ym0jsir5	438	19	the	the	DT
cord-254895-ym0jsir5	438	20	MyD88-independent	MyD88-independent	NNP
cord-254895-ym0jsir5	438	21	toll	toll	NN
cord-254895-ym0jsir5	438	22	-	-	HYPH
cord-254895-ym0jsir5	438	23	like	like	JJ
cord-254895-ym0jsir5	438	24	receptor	receptor	NN
cord-254895-ym0jsir5	438	25	signaling	signal	VBG
cord-254895-ym0jsir5	438	26	pathway	pathway	NN
cord-254895-ym0jsir5	439	1	The	the	DT
cord-254895-ym0jsir5	439	2	RNA	RNA	NNP
cord-254895-ym0jsir5	439	3	helicase	helicase	NN
cord-254895-ym0jsir5	439	4	RIG	rig	NN
cord-254895-ym0jsir5	439	5	-	-	:
cord-254895-ym0jsir5	439	6	I	-PRON-	PRP
cord-254895-ym0jsir5	439	7	has	have	VBZ
cord-254895-ym0jsir5	439	8	an	an	DT
cord-254895-ym0jsir5	439	9	essential	essential	JJ
cord-254895-ym0jsir5	439	10	function	function	NN
cord-254895-ym0jsir5	439	11	in	in	IN
cord-254895-ym0jsir5	439	12	double	double	RB
cord-254895-ym0jsir5	439	13	-	-	HYPH
cord-254895-ym0jsir5	439	14	stranded	strand	VBN
cord-254895-ym0jsir5	439	15	RNA	rna	NN
cord-254895-ym0jsir5	439	16	-	-	HYPH
cord-254895-ym0jsir5	439	17	induced	induce	VBN
cord-254895-ym0jsir5	439	18	innate	innate	JJ
cord-254895-ym0jsir5	439	19	antiviral	antiviral	JJ
cord-254895-ym0jsir5	439	20	responses	response	NNS
cord-254895-ym0jsir5	439	21	Shared	share	VBN
cord-254895-ym0jsir5	439	22	and	and	CC
cord-254895-ym0jsir5	439	23	unique	unique	JJ
cord-254895-ym0jsir5	439	24	functions	function	NNS
cord-254895-ym0jsir5	439	25	of	of	IN
cord-254895-ym0jsir5	439	26	the	the	DT
cord-254895-ym0jsir5	439	27	DExD	DExD	NNS
cord-254895-ym0jsir5	439	28	/	/	SYM
cord-254895-ym0jsir5	439	29	H	h	NN
cord-254895-ym0jsir5	439	30	-	-	HYPH
cord-254895-ym0jsir5	439	31	box	box	NN
cord-254895-ym0jsir5	439	32	helicases	helicase	NNS
cord-254895-ym0jsir5	439	33	RIG	rig	NN
cord-254895-ym0jsir5	439	34	-	-	:
cord-254895-ym0jsir5	439	35	I	I	NNP
cord-254895-ym0jsir5	439	36	,	,	,
cord-254895-ym0jsir5	439	37	MDA5	MDA5	NNP
cord-254895-ym0jsir5	439	38	,	,	,
cord-254895-ym0jsir5	439	39	and	and	CC
cord-254895-ym0jsir5	439	40	LGP2	LGP2	NNP
cord-254895-ym0jsir5	439	41	in	in	IN
cord-254895-ym0jsir5	439	42	antiviral	antiviral	JJ
cord-254895-ym0jsir5	439	43	innate	innate	JJ
cord-254895-ym0jsir5	439	44	immunity	immunity	NN
cord-254895-ym0jsir5	440	1	An	an	DT
cord-254895-ym0jsir5	440	2	RNA	RNA	NNP
cord-254895-ym0jsir5	440	3	helicase	helicase	NN
cord-254895-ym0jsir5	440	4	,	,	,
cord-254895-ym0jsir5	440	5	RHIV-1	RHIV-1	NNS
cord-254895-ym0jsir5	440	6	,	,	,
cord-254895-ym0jsir5	440	7	induced	induce	VBN
cord-254895-ym0jsir5	440	8	by	by	IN
cord-254895-ym0jsir5	440	9	porcine	porcine	JJ
cord-254895-ym0jsir5	440	10	reproductive	reproductive	JJ
cord-254895-ym0jsir5	440	11	and	and	CC
cord-254895-ym0jsir5	440	12	respiratory	respiratory	JJ
cord-254895-ym0jsir5	440	13	syndrome	syndrome	NN
cord-254895-ym0jsir5	440	14	virus	virus	NN
cord-254895-ym0jsir5	440	15	(	(	-LRB-
cord-254895-ym0jsir5	440	16	PRRSV	PRRSV	NNP
cord-254895-ym0jsir5	440	17	)	)	-RRB-
cord-254895-ym0jsir5	440	18	is	be	VBZ
cord-254895-ym0jsir5	440	19	mapped	map	VBN
cord-254895-ym0jsir5	440	20	on	on	IN
cord-254895-ym0jsir5	440	21	porcine	porcine	JJ
cord-254895-ym0jsir5	440	22	chromosome	chromosome	NN
cord-254895-ym0jsir5	440	23	10q13	10q13	CD