id	sid	tid	token	lemma	pos
cord-261532-q923xxn2	1	1	key	key	JJ
cord-261532-q923xxn2	1	2	:	:	:
cord-261532-q923xxn2	1	3	cord-261532-q923xxn2	cord-261532-q923xxn2	NN
cord-261532-q923xxn2	1	4	authors	author	NNS
cord-261532-q923xxn2	1	5	:	:	:
cord-261532-q923xxn2	1	6	Chen	Chen	NNP
cord-261532-q923xxn2	1	7	,	,	,
cord-261532-q923xxn2	1	8	Huihui	Huihui	NNP
cord-261532-q923xxn2	1	9	;	;	:
cord-261532-q923xxn2	1	10	Jiang	Jiang	NNP
cord-261532-q923xxn2	1	11	,	,	,
cord-261532-q923xxn2	2	1	Zhengfan	Zhengfan	NNP
cord-261532-q923xxn2	2	2	title	title	NN
cord-261532-q923xxn2	2	3	:	:	:
cord-261532-q923xxn2	2	4	The	the	DT
cord-261532-q923xxn2	2	5	essential	essential	JJ
cord-261532-q923xxn2	2	6	adaptors	adaptor	NNS
cord-261532-q923xxn2	2	7	of	of	IN
cord-261532-q923xxn2	2	8	innate	innate	JJ
cord-261532-q923xxn2	2	9	immune	immune	JJ
cord-261532-q923xxn2	2	10	signaling	signal	VBG
cord-261532-q923xxn2	2	11	date	date	NN
cord-261532-q923xxn2	2	12	:	:	:
cord-261532-q923xxn2	2	13	2012	2012	CD
cord-261532-q923xxn2	2	14	-	-	SYM
cord-261532-q923xxn2	2	15	09	09	CD
cord-261532-q923xxn2	2	16	-	-	SYM
cord-261532-q923xxn2	2	17	21	21	CD
cord-261532-q923xxn2	2	18	journal	journal	NN
cord-261532-q923xxn2	2	19	:	:	:
cord-261532-q923xxn2	2	20	Protein	Protein	NNP
cord-261532-q923xxn2	2	21	&	&	CC
cord-261532-q923xxn2	2	22	Cell	Cell	NNP
cord-261532-q923xxn2	2	23	DOI	DOI	NNP
cord-261532-q923xxn2	2	24	:	:	:
cord-261532-q923xxn2	2	25	10.1007	10.1007	CD
cord-261532-q923xxn2	2	26	/	/	SYM
cord-261532-q923xxn2	2	27	s13238	s13238	NNP
cord-261532-q923xxn2	2	28	-	-	HYPH
cord-261532-q923xxn2	2	29	012	012	CD
cord-261532-q923xxn2	2	30	-	-	HYPH
cord-261532-q923xxn2	2	31	2063	2063	CD
cord-261532-q923xxn2	2	32	-	-	SYM
cord-261532-q923xxn2	2	33	0	0	CD
cord-261532-q923xxn2	3	1	sha	sha	NNP
cord-261532-q923xxn2	3	2	:	:	:
cord-261532-q923xxn2	4	1	bdd2f6cee151c4613727760f8e62f964472abf10	bdd2f6cee151c4613727760f8e62f964472abf10	NNP
cord-261532-q923xxn2	4	2	doc_id	doc_id	CD
cord-261532-q923xxn2	4	3	:	:	:
cord-261532-q923xxn2	4	4	261532	261532	CD
cord-261532-q923xxn2	4	5	cord_uid	cord_uid	NNS
cord-261532-q923xxn2	4	6	:	:	:
cord-261532-q923xxn2	5	1	q923xxn2	q923xxn2	NNP
cord-261532-q923xxn2	5	2	Microbial	microbial	JJ
cord-261532-q923xxn2	5	3	components	component	NNS
cord-261532-q923xxn2	5	4	and	and	CC
cord-261532-q923xxn2	5	5	the	the	DT
cord-261532-q923xxn2	5	6	endogenous	endogenous	JJ
cord-261532-q923xxn2	5	7	molecules	molecule	NNS
cord-261532-q923xxn2	5	8	released	release	VBN
cord-261532-q923xxn2	5	9	from	from	IN
cord-261532-q923xxn2	5	10	damaged	damaged	JJ
cord-261532-q923xxn2	5	11	cells	cell	NNS
cord-261532-q923xxn2	5	12	can	can	MD
cord-261532-q923xxn2	5	13	stimulate	stimulate	VB
cord-261532-q923xxn2	5	14	germ	germ	NN
cord-261532-q923xxn2	5	15	-	-	HYPH
cord-261532-q923xxn2	5	16	line	line	NN
cord-261532-q923xxn2	5	17	-	-	HYPH
cord-261532-q923xxn2	5	18	encoded	encode	VBN
cord-261532-q923xxn2	5	19	pattern	pattern	NN
cord-261532-q923xxn2	5	20	recognition	recognition	NN
cord-261532-q923xxn2	5	21	receptors	receptor	NNS
cord-261532-q923xxn2	5	22	(	(	-LRB-
cord-261532-q923xxn2	5	23	PRRs	PRRs	NNP
cord-261532-q923xxn2	5	24	)	)	-RRB-
cord-261532-q923xxn2	5	25	to	to	TO
cord-261532-q923xxn2	5	26	transduce	transduce	VB
cord-261532-q923xxn2	5	27	signals	signal	NNS
cord-261532-q923xxn2	5	28	to	to	IN
cord-261532-q923xxn2	5	29	the	the	DT
cord-261532-q923xxn2	5	30	hub	hub	NN
cord-261532-q923xxn2	5	31	of	of	IN
cord-261532-q923xxn2	5	32	the	the	DT
cord-261532-q923xxn2	5	33	innate	innate	JJ
cord-261532-q923xxn2	5	34	immune	immune	JJ
cord-261532-q923xxn2	5	35	signaling	signal	VBG
cord-261532-q923xxn2	5	36	network	network	NN
cord-261532-q923xxn2	5	37	-	-	:
cord-261532-q923xxn2	5	38	the	the	DT
cord-261532-q923xxn2	5	39	adaptor	adaptor	NN
cord-261532-q923xxn2	5	40	proteins	protein	NNS
cord-261532-q923xxn2	6	1	MyD88	MyD88	NNP
cord-261532-q923xxn2	6	2	/	/	SYM
cord-261532-q923xxn2	6	3	TRIF	TRIF	NNP
cord-261532-q923xxn2	6	4	/	/	SYM
cord-261532-q923xxn2	6	5	MAVS	MAVS	NNP
cord-261532-q923xxn2	6	6	/	/	SYM
cord-261532-q923xxn2	6	7	STING	STING	NNP
cord-261532-q923xxn2	6	8	/	/	SYM
cord-261532-q923xxn2	6	9	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	6	10	,	,	,
cord-261532-q923xxn2	6	11	where	where	WRB
cord-261532-q923xxn2	6	12	integrated	integrate	VBN
cord-261532-q923xxn2	6	13	signals	signal	NNS
cord-261532-q923xxn2	6	14	relay	relay	NN
cord-261532-q923xxn2	6	15	to	to	IN
cord-261532-q923xxn2	6	16	the	the	DT
cord-261532-q923xxn2	6	17	relevant	relevant	JJ
cord-261532-q923xxn2	6	18	transcription	transcription	NN
cord-261532-q923xxn2	6	19	factors	factor	NNS
cord-261532-q923xxn2	6	20	IRF3	IRF3	NNP
cord-261532-q923xxn2	6	21	/	/	SYM
cord-261532-q923xxn2	6	22	IRF7	IRF7	NNP
cord-261532-q923xxn2	6	23	/	/	SYM
cord-261532-q923xxn2	6	24	NF	NF	NNP
cord-261532-q923xxn2	6	25	-	-	HYPH
cord-261532-q923xxn2	6	26	κB/	κB/	NNP
cord-261532-q923xxn2	7	1	AP-1	AP-1	NNP
cord-261532-q923xxn2	8	1	and	and	CC
cord-261532-q923xxn2	8	2	the	the	DT
cord-261532-q923xxn2	8	3	signal	signal	NN
cord-261532-q923xxn2	8	4	transducer	transducer	NN
cord-261532-q923xxn2	8	5	and	and	CC
cord-261532-q923xxn2	8	6	activator	activator	NN
cord-261532-q923xxn2	8	7	of	of	IN
cord-261532-q923xxn2	8	8	transcription	transcription	NN
cord-261532-q923xxn2	8	9	6	6	CD
cord-261532-q923xxn2	8	10	(	(	-LRB-
cord-261532-q923xxn2	8	11	STAT6	stat6	NN
cord-261532-q923xxn2	8	12	)	)	-RRB-
cord-261532-q923xxn2	9	1	to	to	TO
cord-261532-q923xxn2	9	2	trigger	trigger	VB
cord-261532-q923xxn2	9	3	the	the	DT
cord-261532-q923xxn2	9	4	expression	expression	NN
cord-261532-q923xxn2	9	5	of	of	IN
cord-261532-q923xxn2	9	6	type	type	NN
cord-261532-q923xxn2	9	7	I	-PRON-	PRP
cord-261532-q923xxn2	9	8	interferons	interferon	NNS
cord-261532-q923xxn2	9	9	and	and	CC
cord-261532-q923xxn2	9	10	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	9	11	cytokines	cytokine	NNS
cord-261532-q923xxn2	9	12	or	or	CC
cord-261532-q923xxn2	9	13	the	the	DT
cord-261532-q923xxn2	9	14	assembly	assembly	NN
cord-261532-q923xxn2	9	15	of	of	IN
cord-261532-q923xxn2	9	16	inflammasomes	inflammasomes	NNP
cord-261532-q923xxn2	9	17	.	.	.
cord-261532-q923xxn2	10	1	Most	Most	JJS
cord-261532-q923xxn2	10	2	pleiotropic	pleiotropic	JJ
cord-261532-q923xxn2	10	3	cytokines	cytokine	NNS
cord-261532-q923xxn2	10	4	are	be	VBP
cord-261532-q923xxn2	10	5	secreted	secrete	VBN
cord-261532-q923xxn2	10	6	and	and	CC
cord-261532-q923xxn2	10	7	bind	bind	VB
cord-261532-q923xxn2	10	8	to	to	IN
cord-261532-q923xxn2	10	9	specific	specific	JJ
cord-261532-q923xxn2	10	10	receptors	receptor	NNS
cord-261532-q923xxn2	10	11	,	,	,
cord-261532-q923xxn2	10	12	activating	activate	VBG
cord-261532-q923xxn2	10	13	the	the	DT
cord-261532-q923xxn2	10	14	signaling	signal	VBG
cord-261532-q923xxn2	10	15	pathways	pathway	NNS
cord-261532-q923xxn2	10	16	including	include	VBG
cord-261532-q923xxn2	10	17	JAK	JAK	NNP
cord-261532-q923xxn2	10	18	-	-	HYPH
cord-261532-q923xxn2	10	19	STAT	STAT	NNP
cord-261532-q923xxn2	10	20	for	for	IN
cord-261532-q923xxn2	10	21	the	the	DT
cord-261532-q923xxn2	10	22	proliferation	proliferation	NN
cord-261532-q923xxn2	10	23	,	,	,
cord-261532-q923xxn2	10	24	differentiation	differentiation	NN
cord-261532-q923xxn2	10	25	and	and	CC
cord-261532-q923xxn2	10	26	functional	functional	JJ
cord-261532-q923xxn2	10	27	capacity	capacity	NN
cord-261532-q923xxn2	10	28	of	of	IN
cord-261532-q923xxn2	10	29	immune	immune	JJ
cord-261532-q923xxn2	10	30	cells	cell	NNS
cord-261532-q923xxn2	10	31	.	.	.
cord-261532-q923xxn2	11	1	This	this	DT
cord-261532-q923xxn2	11	2	review	review	NN
cord-261532-q923xxn2	11	3	focuses	focus	VBZ
cord-261532-q923xxn2	11	4	on	on	IN
cord-261532-q923xxn2	11	5	several	several	JJ
cord-261532-q923xxn2	11	6	critical	critical	JJ
cord-261532-q923xxn2	11	7	adaptors	adaptor	NNS
cord-261532-q923xxn2	11	8	in	in	IN
cord-261532-q923xxn2	11	9	innate	innate	JJ
cord-261532-q923xxn2	11	10	immune	immune	JJ
cord-261532-q923xxn2	11	11	signaling	signal	VBG
cord-261532-q923xxn2	11	12	cascades	cascade	NNS
cord-261532-q923xxn2	11	13	and	and	CC
cord-261532-q923xxn2	11	14	recent	recent	JJ
cord-261532-q923xxn2	11	15	progress	progress	NN
cord-261532-q923xxn2	11	16	in	in	IN
cord-261532-q923xxn2	11	17	their	-PRON-	PRP$
cord-261532-q923xxn2	11	18	molecular	molecular	JJ
cord-261532-q923xxn2	11	19	mechanisms	mechanism	NNS
cord-261532-q923xxn2	11	20	.	.	.
cord-261532-q923xxn2	12	1	The	the	DT
cord-261532-q923xxn2	12	2	innate	innate	JJ
cord-261532-q923xxn2	12	3	immune	immune	JJ
cord-261532-q923xxn2	12	4	response	response	NN
cord-261532-q923xxn2	12	5	is	be	VBZ
cord-261532-q923xxn2	12	6	initiated	initiate	VBN
cord-261532-q923xxn2	12	7	by	by	IN
cord-261532-q923xxn2	12	8	germline	germline	NN
cord-261532-q923xxn2	12	9	-	-	HYPH
cord-261532-q923xxn2	12	10	encoded	encode	VBN
cord-261532-q923xxn2	12	11	pattern	pattern	NN
cord-261532-q923xxn2	12	12	recognition	recognition	NN
cord-261532-q923xxn2	12	13	receptors	receptor	NNS
cord-261532-q923xxn2	12	14	(	(	-LRB-
cord-261532-q923xxn2	12	15	PRRs	PRRs	NNP
cord-261532-q923xxn2	12	16	)	)	-RRB-
cord-261532-q923xxn2	12	17	that	that	WDT
cord-261532-q923xxn2	12	18	serve	serve	VBP
cord-261532-q923xxn2	12	19	as	as	IN
cord-261532-q923xxn2	12	20	sensors	sensor	NNS
cord-261532-q923xxn2	12	21	to	to	IN
cord-261532-q923xxn2	12	22	pathogen	pathogen	NN
cord-261532-q923xxn2	12	23	-	-	HYPH
cord-261532-q923xxn2	12	24	associated	associate	VBN
cord-261532-q923xxn2	12	25	molecular	molecular	JJ
cord-261532-q923xxn2	12	26	patterns	pattern	NNS
cord-261532-q923xxn2	12	27	(	(	-LRB-
cord-261532-q923xxn2	12	28	PAMPs	pamp	NNS
cord-261532-q923xxn2	12	29	)	)	-RRB-
cord-261532-q923xxn2	12	30	and	and	CC
cord-261532-q923xxn2	12	31	damage	damage	NN
cord-261532-q923xxn2	12	32	-	-	HYPH
cord-261532-q923xxn2	12	33	associated	associate	VBN
cord-261532-q923xxn2	12	34	molecular	molecular	JJ
cord-261532-q923xxn2	12	35	patterns	pattern	NNS
cord-261532-q923xxn2	12	36	(	(	-LRB-
cord-261532-q923xxn2	12	37	DAMPs	damp	NNS
cord-261532-q923xxn2	12	38	)	)	-RRB-
cord-261532-q923xxn2	12	39	,	,	,
cord-261532-q923xxn2	12	40	providing	provide	VBG
cord-261532-q923xxn2	12	41	the	the	DT
cord-261532-q923xxn2	12	42	first	first	JJ
cord-261532-q923xxn2	12	43	line	line	NN
cord-261532-q923xxn2	12	44	of	of	IN
cord-261532-q923xxn2	12	45	defense	defense	NN
cord-261532-q923xxn2	12	46	against	against	IN
cord-261532-q923xxn2	12	47	microbial	microbial	JJ
cord-261532-q923xxn2	12	48	infection	infection	NN
cord-261532-q923xxn2	12	49	or	or	CC
cord-261532-q923xxn2	12	50	endogenous	endogenous	JJ
cord-261532-q923xxn2	12	51	danger	danger	NN
cord-261532-q923xxn2	12	52	signals	signal	NNS
cord-261532-q923xxn2	12	53	.	.	.
cord-261532-q923xxn2	13	1	PAMPs	pamp	NNS
cord-261532-q923xxn2	13	2	refer	refer	VBP
cord-261532-q923xxn2	13	3	to	to	IN
cord-261532-q923xxn2	13	4	molecules	molecule	NNS
cord-261532-q923xxn2	13	5	released	release	VBN
cord-261532-q923xxn2	13	6	by	by	IN
cord-261532-q923xxn2	13	7	pathogenic	pathogenic	JJ
cord-261532-q923xxn2	13	8	bacteria	bacteria	NNS
cord-261532-q923xxn2	13	9	(	(	-LRB-
cord-261532-q923xxn2	13	10	e.g.	e.g.	RB
cord-261532-q923xxn2	13	11	lipopolysaccharides	lipopolysaccharides	NNP
cord-261532-q923xxn2	13	12	,	,	,
cord-261532-q923xxn2	13	13	LPS	LPS	NNP
cord-261532-q923xxn2	13	14	)	)	-RRB-
cord-261532-q923xxn2	13	15	or	or	CC
cord-261532-q923xxn2	13	16	viruses	virus	NNS
cord-261532-q923xxn2	13	17	(	(	-LRB-
cord-261532-q923xxn2	13	18	e.g.	e.g.	IN
cord-261532-q923xxn2	13	19	dsRNA/	dsRNA/	NNP
cord-261532-q923xxn2	13	20	ssRNA	ssRNA	NNP
cord-261532-q923xxn2	13	21	/	/	SYM
cord-261532-q923xxn2	13	22	dsDNA	dsDNA	NNP
cord-261532-q923xxn2	13	23	/	/	SYM
cord-261532-q923xxn2	13	24	ssDNA	ssdna	RB
cord-261532-q923xxn2	13	25	)	)	-RRB-
cord-261532-q923xxn2	13	26	,	,	,
cord-261532-q923xxn2	13	27	whereas	whereas	IN
cord-261532-q923xxn2	13	28	damaged	damage	VBN
cord-261532-q923xxn2	13	29	or	or	CC
cord-261532-q923xxn2	13	30	dying	die	VBG
cord-261532-q923xxn2	13	31	cells	cell	NNS
cord-261532-q923xxn2	13	32	release	release	VBP
cord-261532-q923xxn2	13	33	endogenous	endogenous	JJ
cord-261532-q923xxn2	13	34	molecules	molecule	NNS
cord-261532-q923xxn2	13	35	termed	term	VBN
cord-261532-q923xxn2	13	36	DAMPs	damp	NNS
cord-261532-q923xxn2	13	37	(	(	-LRB-
cord-261532-q923xxn2	13	38	such	such	JJ
cord-261532-q923xxn2	13	39	as	as	IN
cord-261532-q923xxn2	13	40	adenosine	adenosine	NN
cord-261532-q923xxn2	13	41	triphosphate	triphosphate	NN
cord-261532-q923xxn2	13	42	,	,	,
cord-261532-q923xxn2	13	43	ATP	ATP	NNP
cord-261532-q923xxn2	13	44	;	;	:
cord-261532-q923xxn2	13	45	uric	uric	JJ
cord-261532-q923xxn2	13	46	acid	acid	NN
cord-261532-q923xxn2	13	47	crystals	crystal	NNS
cord-261532-q923xxn2	13	48	and	and	CC
cord-261532-q923xxn2	13	49	S100	s100	NN
cord-261532-q923xxn2	13	50	proteins	protein	NNS
cord-261532-q923xxn2	13	51	)	)	-RRB-
cord-261532-q923xxn2	13	52	that	that	WDT
cord-261532-q923xxn2	13	53	activate	activate	VBP
cord-261532-q923xxn2	13	54	the	the	DT
cord-261532-q923xxn2	13	55	immune	immune	JJ
cord-261532-q923xxn2	13	56	system	system	NN
cord-261532-q923xxn2	13	57	in	in	IN
cord-261532-q923xxn2	13	58	a	a	DT
cord-261532-q923xxn2	13	59	way	way	NN
cord-261532-q923xxn2	13	60	analo	analo	NNS
cord-261532-q923xxn2	13	61	-	-	HYPH
cord-261532-q923xxn2	13	62	gous	gous	JJ
cord-261532-q923xxn2	13	63	to	to	IN
cord-261532-q923xxn2	13	64	PAMPs	pamp	NNS
cord-261532-q923xxn2	13	65	.	.	.
cord-261532-q923xxn2	14	1	Currently	currently	RB
cord-261532-q923xxn2	14	2	identified	identify	VBN
cord-261532-q923xxn2	14	3	PRRs	prr	NNS
cord-261532-q923xxn2	14	4	include	include	VBP
cord-261532-q923xxn2	14	5	the	the	DT
cord-261532-q923xxn2	14	6	membrane	membrane	NN
cord-261532-q923xxn2	14	7	-	-	HYPH
cord-261532-q923xxn2	14	8	bound	bind	VBN
cord-261532-q923xxn2	14	9	Toll	toll	NN
cord-261532-q923xxn2	14	10	-	-	HYPH
cord-261532-q923xxn2	14	11	like	like	JJ
cord-261532-q923xxn2	14	12	receptors	receptor	NNS
cord-261532-q923xxn2	14	13	(	(	-LRB-
cord-261532-q923xxn2	14	14	TLRs	TLRs	NNP
cord-261532-q923xxn2	14	15	)	)	-RRB-
cord-261532-q923xxn2	14	16	and	and	CC
cord-261532-q923xxn2	14	17	C	c	NN
cord-261532-q923xxn2	14	18	-	-	HYPH
cord-261532-q923xxn2	14	19	type	type	NN
cord-261532-q923xxn2	14	20	lectin	lectin	NN
cord-261532-q923xxn2	14	21	receptors	receptor	NNS
cord-261532-q923xxn2	14	22	(	(	-LRB-
cord-261532-q923xxn2	14	23	CLRs	CLRs	NNP
cord-261532-q923xxn2	14	24	)	)	-RRB-
cord-261532-q923xxn2	14	25	,	,	,
cord-261532-q923xxn2	14	26	as	as	RB
cord-261532-q923xxn2	14	27	well	well	RB
cord-261532-q923xxn2	14	28	as	as	IN
cord-261532-q923xxn2	14	29	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	14	30	retinoic	retinoic	JJ
cord-261532-q923xxn2	14	31	acid	acid	NN
cord-261532-q923xxn2	14	32	-	-	HYPH
cord-261532-q923xxn2	14	33	inducible	inducible	JJ
cord-261532-q923xxn2	14	34	gene	gene	NN
cord-261532-q923xxn2	15	1	I	-PRON-	PRP
cord-261532-q923xxn2	15	2	(	(	-LRB-
cord-261532-q923xxn2	15	3	RIG	RIG	NNP
cord-261532-q923xxn2	15	4	-	-	HYPH
cord-261532-q923xxn2	15	5	I)-like	I)-like	NNP
cord-261532-q923xxn2	15	6	receptors	receptor	NNS
cord-261532-q923xxn2	15	7	(	(	-LRB-
cord-261532-q923xxn2	15	8	RLRs	RLRs	NNP
cord-261532-q923xxn2	15	9	)	)	-RRB-
cord-261532-q923xxn2	15	10	,	,	,
cord-261532-q923xxn2	15	11	nucleotide	nucleotide	NN
cord-261532-q923xxn2	15	12	-	-	HYPH
cord-261532-q923xxn2	15	13	binding	bind	VBG
cord-261532-q923xxn2	15	14	oligomerization	oligomerization	NN
cord-261532-q923xxn2	15	15	domain	domain	NN
cord-261532-q923xxn2	15	16	(	(	-LRB-
cord-261532-q923xxn2	15	17	NOD)-like	nod)-like	CD
cord-261532-q923xxn2	15	18	receptors	receptor	NNS
cord-261532-q923xxn2	15	19	(	(	-LRB-
cord-261532-q923xxn2	15	20	NLRs	NLRs	NNP
cord-261532-q923xxn2	15	21	)	)	-RRB-
cord-261532-q923xxn2	15	22	and	and	CC
cord-261532-q923xxn2	15	23	DNA	dna	NN
cord-261532-q923xxn2	15	24	sensors	sensor	NNS
cord-261532-q923xxn2	15	25	(	(	-LRB-
cord-261532-q923xxn2	15	26	e.g.	e.g.	RB
cord-261532-q923xxn2	15	27	DNAdependent	DNAdependent	NNP
cord-261532-q923xxn2	15	28	activator	activator	NN
cord-261532-q923xxn2	15	29	of	of	IN
cord-261532-q923xxn2	15	30	interferon	interferon	NN
cord-261532-q923xxn2	15	31	regulatory	regulatory	JJ
cord-261532-q923xxn2	15	32	factor	factor	NN
cord-261532-q923xxn2	15	33	,	,	,
cord-261532-q923xxn2	15	34	DAI	DAI	NNP
cord-261532-q923xxn2	15	35	;	;	,
cord-261532-q923xxn2	15	36	absent	absent	JJ
cord-261532-q923xxn2	15	37	in	in	IN
cord-261532-q923xxn2	15	38	melanoma-2	melanoma-2	NN
cord-261532-q923xxn2	15	39	,	,	,
cord-261532-q923xxn2	15	40	AIM2	AIM2	NNP
cord-261532-q923xxn2	15	41	)	)	-RRB-
cord-261532-q923xxn2	15	42	.	.	.
cord-261532-q923xxn2	16	1	PRRs	prr	NNS
cord-261532-q923xxn2	16	2	have	have	VBP
cord-261532-q923xxn2	16	3	evolved	evolve	VBN
cord-261532-q923xxn2	16	4	in	in	IN
cord-261532-q923xxn2	16	5	different	different	JJ
cord-261532-q923xxn2	16	6	cell	cell	NN
cord-261532-q923xxn2	16	7	types	type	NNS
cord-261532-q923xxn2	16	8	to	to	TO
cord-261532-q923xxn2	16	9	detect	detect	VB
cord-261532-q923xxn2	16	10	PAMPs	pamp	NNS
cord-261532-q923xxn2	16	11	or	or	CC
cord-261532-q923xxn2	16	12	DAMPs	damp	NNS
cord-261532-q923xxn2	16	13	,	,	,
cord-261532-q923xxn2	16	14	including	include	VBG
cord-261532-q923xxn2	16	15	hematopoietic	hematopoietic	JJ
cord-261532-q923xxn2	16	16	cells	cell	NNS
cord-261532-q923xxn2	16	17	like	like	IN
cord-261532-q923xxn2	16	18	dendritic	dendritic	JJ
cord-261532-q923xxn2	16	19	cells	cell	NNS
cord-261532-q923xxn2	16	20	(	(	-LRB-
cord-261532-q923xxn2	16	21	DCs	DCs	NNP
cord-261532-q923xxn2	16	22	)	)	-RRB-
cord-261532-q923xxn2	16	23	and	and	CC
cord-261532-q923xxn2	16	24	macrophages	macrophage	NNS
cord-261532-q923xxn2	16	25	as	as	RB
cord-261532-q923xxn2	16	26	well	well	RB
cord-261532-q923xxn2	16	27	as	as	IN
cord-261532-q923xxn2	16	28	epithelial	epithelial	JJ
cord-261532-q923xxn2	16	29	cells	cell	NNS
cord-261532-q923xxn2	16	30	and	and	CC
cord-261532-q923xxn2	16	31	fibroblasts	fibroblast	NNS
cord-261532-q923xxn2	16	32	.	.	.
cord-261532-q923xxn2	17	1	These	these	DT
cord-261532-q923xxn2	17	2	receptors	receptor	NNS
cord-261532-q923xxn2	17	3	can	can	MD
cord-261532-q923xxn2	17	4	recruit	recruit	VB
cord-261532-q923xxn2	17	5	specific	specific	JJ
cord-261532-q923xxn2	17	6	adaptor	adaptor	NN
cord-261532-q923xxn2	17	7	proteins	protein	NNS
cord-261532-q923xxn2	17	8	,	,	,
cord-261532-q923xxn2	17	9	like	like	IN
cord-261532-q923xxn2	17	10	myeloid	myeloid	JJ
cord-261532-q923xxn2	17	11	differentiation	differentiation	NN
cord-261532-q923xxn2	17	12	primary	primary	JJ
cord-261532-q923xxn2	17	13	response	response	NN
cord-261532-q923xxn2	17	14	gene	gene	NN
cord-261532-q923xxn2	17	15	88	88	CD
cord-261532-q923xxn2	17	16	(	(	-LRB-
cord-261532-q923xxn2	17	17	MyD88	MyD88	NNS
cord-261532-q923xxn2	17	18	)	)	-RRB-
cord-261532-q923xxn2	17	19	or	or	CC
cord-261532-q923xxn2	17	20	Toll	toll	NN
cord-261532-q923xxn2	17	21	/	/	SYM
cord-261532-q923xxn2	17	22	interleukin-1	interleukin-1	NN
cord-261532-q923xxn2	17	23	receptor	receptor	NN
cord-261532-q923xxn2	17	24	(	(	-LRB-
cord-261532-q923xxn2	17	25	TIR	TIR	NNP
cord-261532-q923xxn2	17	26	)	)	-RRB-
cord-261532-q923xxn2	17	27	domain	domain	NN
cord-261532-q923xxn2	17	28	-	-	HYPH
cord-261532-q923xxn2	17	29	containing	contain	VBG
cord-261532-q923xxn2	17	30	adaptor	adaptor	NN
cord-261532-q923xxn2	17	31	inducing	induce	VBG
cord-261532-q923xxn2	17	32	IFN	IFN	NNP
cord-261532-q923xxn2	17	33	-	-	HYPH
cord-261532-q923xxn2	17	34	β	β	NNP
cord-261532-q923xxn2	17	35	(	(	-LRB-
cord-261532-q923xxn2	17	36	TRIF	TRIF	NNP
cord-261532-q923xxn2	17	37	)	)	-RRB-
cord-261532-q923xxn2	17	38	in	in	IN
cord-261532-q923xxn2	17	39	the	the	DT
cord-261532-q923xxn2	17	40	TLR	TLR	NNP
cord-261532-q923xxn2	17	41	pathway	pathway	NN
cord-261532-q923xxn2	17	42	,	,	,
cord-261532-q923xxn2	17	43	mitochondrial	mitochondrial	JJ
cord-261532-q923xxn2	17	44	antiviral	antiviral	JJ
cord-261532-q923xxn2	17	45	signaling	signal	VBG
cord-261532-q923xxn2	17	46	protein	protein	NN
cord-261532-q923xxn2	17	47	(	(	-LRB-
cord-261532-q923xxn2	17	48	MAVS	MAVS	NNP
cord-261532-q923xxn2	17	49	)	)	-RRB-
cord-261532-q923xxn2	17	50	downstream	downstream	NN
cord-261532-q923xxn2	17	51	of	of	IN
cord-261532-q923xxn2	17	52	RLRs	rlr	NNS
cord-261532-q923xxn2	17	53	,	,	,
cord-261532-q923xxn2	17	54	stimulator	stimulator	NN
cord-261532-q923xxn2	17	55	of	of	IN
cord-261532-q923xxn2	17	56	interferon	interferon	NN
cord-261532-q923xxn2	17	57	genes	gene	NNS
cord-261532-q923xxn2	17	58	(	(	-LRB-
cord-261532-q923xxn2	17	59	STING	STING	NNP
cord-261532-q923xxn2	17	60	)	)	-RRB-
cord-261532-q923xxn2	17	61	in	in	IN
cord-261532-q923xxn2	17	62	the	the	DT
cord-261532-q923xxn2	17	63	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	17	64	DNA	dna	NN
cord-261532-q923xxn2	17	65	response	response	NN
cord-261532-q923xxn2	17	66	pathway	pathway	NN
cord-261532-q923xxn2	17	67	and	and	CC
cord-261532-q923xxn2	17	68	,	,	,
cord-261532-q923xxn2	17	69	cysteine	cysteine	JJ
cord-261532-q923xxn2	17	70	aspartic	aspartic	JJ
cord-261532-q923xxn2	17	71	protease	protease	NN
cord-261532-q923xxn2	17	72	1	1	CD
cord-261532-q923xxn2	17	73	(	(	-LRB-
cord-261532-q923xxn2	17	74	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	17	75	)	)	-RRB-
cord-261532-q923xxn2	17	76	as	as	IN
cord-261532-q923xxn2	17	77	part	part	NN
cord-261532-q923xxn2	17	78	of	of	IN
cord-261532-q923xxn2	17	79	the	the	DT
cord-261532-q923xxn2	17	80	inflammasome	inflammasome	NN
cord-261532-q923xxn2	17	81	,	,	,
cord-261532-q923xxn2	17	82	all	all	DT
cord-261532-q923xxn2	17	83	of	of	IN
cord-261532-q923xxn2	17	84	which	which	WDT
cord-261532-q923xxn2	17	85	orchestrate	orchestrate	VBP
cord-261532-q923xxn2	17	86	the	the	DT
cord-261532-q923xxn2	17	87	host	host	NN
cord-261532-q923xxn2	17	88	innate	innate	JJ
cord-261532-q923xxn2	17	89	responses	response	NNS
cord-261532-q923xxn2	17	90	,	,	,
cord-261532-q923xxn2	17	91	through	through	IN
cord-261532-q923xxn2	17	92	activation	activation	NN
cord-261532-q923xxn2	17	93	of	of	IN
cord-261532-q923xxn2	17	94	transcriptional	transcriptional	JJ
cord-261532-q923xxn2	17	95	factors	factor	NNS
cord-261532-q923xxn2	17	96	such	such	JJ
cord-261532-q923xxn2	17	97	as	as	IN
cord-261532-q923xxn2	17	98	nuclear	nuclear	JJ
cord-261532-q923xxn2	17	99	factor	factor	NN
cord-261532-q923xxn2	17	100	κB	κB	.
cord-261532-q923xxn2	18	1	(	(	-LRB-
cord-261532-q923xxn2	18	2	NF	nf	NN
cord-261532-q923xxn2	18	3	-	-	HYPH
cord-261532-q923xxn2	18	4	κB	κB	NNP
cord-261532-q923xxn2	18	5	)	)	-RRB-
cord-261532-q923xxn2	18	6	,	,	,
cord-261532-q923xxn2	18	7	activator	activator	NN
cord-261532-q923xxn2	18	8	protein	protein	NN
cord-261532-q923xxn2	18	9	1	1	CD
cord-261532-q923xxn2	18	10	(	(	-LRB-
cord-261532-q923xxn2	18	11	AP-1	AP-1	NNP
cord-261532-q923xxn2	18	12	)	)	-RRB-
cord-261532-q923xxn2	18	13	and	and	CC
cord-261532-q923xxn2	18	14	interferon	interferon	NN
cord-261532-q923xxn2	18	15	regulatory	regulatory	JJ
cord-261532-q923xxn2	18	16	factors	factor	NNS
cord-261532-q923xxn2	18	17	(	(	-LRB-
cord-261532-q923xxn2	18	18	IRFs	IRFs	NNP
cord-261532-q923xxn2	18	19	)	)	-RRB-
cord-261532-q923xxn2	18	20	,	,	.
cord-261532-q923xxn2	19	1	to	to	TO
cord-261532-q923xxn2	19	2	trigger	trigger	VB
cord-261532-q923xxn2	19	3	the	the	DT
cord-261532-q923xxn2	19	4	production	production	NN
cord-261532-q923xxn2	19	5	of	of	IN
cord-261532-q923xxn2	19	6	type	type	NN
cord-261532-q923xxn2	19	7	І	і	CD
cord-261532-q923xxn2	19	8	interferons	interferon	NNS
cord-261532-q923xxn2	19	9	(	(	-LRB-
cord-261532-q923xxn2	19	10	IFNs	IFNs	NNP
cord-261532-q923xxn2	19	11	)	)	-RRB-
cord-261532-q923xxn2	19	12	,	,	,
cord-261532-q923xxn2	19	13	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	19	14	cytokines	cytokine	NNS
cord-261532-q923xxn2	19	15	and	and	CC
cord-261532-q923xxn2	19	16	chemokines	chemokine	NNS
cord-261532-q923xxn2	19	17	.	.	.
cord-261532-q923xxn2	20	1	Upon	upon	IN
cord-261532-q923xxn2	20	2	secretion	secretion	NN
cord-261532-q923xxn2	20	3	,	,	,
cord-261532-q923xxn2	20	4	the	the	DT
cord-261532-q923xxn2	20	5	cytokines	cytokine	NNS
cord-261532-q923xxn2	20	6	function	function	VBP
cord-261532-q923xxn2	20	7	in	in	IN
cord-261532-q923xxn2	20	8	an	an	DT
cord-261532-q923xxn2	20	9	auto	auto	NN
cord-261532-q923xxn2	20	10	-	-	HYPH
cord-261532-q923xxn2	20	11	or	or	CC
cord-261532-q923xxn2	20	12	paracrine	paracrine	JJ
cord-261532-q923xxn2	20	13	manner	manner	NN
cord-261532-q923xxn2	20	14	to	to	TO
cord-261532-q923xxn2	20	15	induce	induce	VB
cord-261532-q923xxn2	20	16	the	the	DT
cord-261532-q923xxn2	20	17	expression	expression	NN
cord-261532-q923xxn2	20	18	of	of	IN
cord-261532-q923xxn2	20	19	hundreds	hundred	NNS
cord-261532-q923xxn2	20	20	of	of	IN
cord-261532-q923xxn2	20	21	effecter	effecter	NN
cord-261532-q923xxn2	20	22	genes	gene	NNS
cord-261532-q923xxn2	20	23	involved	involve	VBN
cord-261532-q923xxn2	20	24	in	in	IN
cord-261532-q923xxn2	20	25	the	the	DT
cord-261532-q923xxn2	20	26	generation	generation	NN
cord-261532-q923xxn2	20	27	of	of	IN
cord-261532-q923xxn2	20	28	the	the	DT
cord-261532-q923xxn2	20	29	innate	innate	JJ
cord-261532-q923xxn2	20	30	anti	anti	JJ
cord-261532-q923xxn2	20	31	-	-	JJ
cord-261532-q923xxn2	20	32	infection	infection	JJ
cord-261532-q923xxn2	20	33	state	state	NN
cord-261532-q923xxn2	20	34	(	(	-LRB-
cord-261532-q923xxn2	20	35	e.g.	e.g.	IN
cord-261532-q923xxn2	20	36	the	the	DT
cord-261532-q923xxn2	20	37	Janus	Janus	NNP
cord-261532-q923xxn2	20	38	kinase	kinase	NN
cord-261532-q923xxn2	20	39	(	(	-LRB-
cord-261532-q923xxn2	20	40	JAK)-signal	jak)-signal	JJ
cord-261532-q923xxn2	20	41	transducer	transducer	NN
cord-261532-q923xxn2	20	42	and	and	CC
cord-261532-q923xxn2	20	43	activator	activator	NN
cord-261532-q923xxn2	20	44	of	of	IN
cord-261532-q923xxn2	20	45	transcription	transcription	NN
cord-261532-q923xxn2	20	46	(	(	-LRB-
cord-261532-q923xxn2	20	47	STAT	stat	NN
cord-261532-q923xxn2	20	48	)	)	-RRB-
cord-261532-q923xxn2	20	49	pathway	pathway	NN
cord-261532-q923xxn2	20	50	activated	activate	VBN
cord-261532-q923xxn2	20	51	by	by	IN
cord-261532-q923xxn2	20	52	secreted	secrete	VBN
cord-261532-q923xxn2	20	53	type	type	NN
cord-261532-q923xxn2	20	54	I	-PRON-	PRP
cord-261532-q923xxn2	20	55	interferons	interferon	NNS
cord-261532-q923xxn2	20	56	)	)	-RRB-
cord-261532-q923xxn2	21	1	(	(	-LRB-
cord-261532-q923xxn2	21	2	Brierley	Brierley	NNP
cord-261532-q923xxn2	21	3	and	and	CC
cord-261532-q923xxn2	21	4	Fish	Fish	NNP
cord-261532-q923xxn2	21	5	,	,	,
cord-261532-q923xxn2	21	6	2005	2005	CD
cord-261532-q923xxn2	21	7	)	)	-RRB-
cord-261532-q923xxn2	21	8	.	.	.
cord-261532-q923xxn2	22	1	Many	many	JJ
cord-261532-q923xxn2	22	2	of	of	IN
cord-261532-q923xxn2	22	3	these	these	DT
cord-261532-q923xxn2	22	4	innate	innate	JJ
cord-261532-q923xxn2	22	5	immune	immune	NN
cord-261532-q923xxn2	22	6	-	-	HYPH
cord-261532-q923xxn2	22	7	stimulated	stimulate	VBN
cord-261532-q923xxn2	22	8	proteins	protein	NNS
cord-261532-q923xxn2	22	9	can	can	MD
cord-261532-q923xxn2	22	10	initiate	initiate	VB
cord-261532-q923xxn2	22	11	adaptive	adaptive	JJ
cord-261532-q923xxn2	22	12	immune	immune	JJ
cord-261532-q923xxn2	22	13	responses	response	NNS
cord-261532-q923xxn2	22	14	involving	involve	VBG
cord-261532-q923xxn2	22	15	antibody	antibody	NN
cord-261532-q923xxn2	22	16	production	production	NN
cord-261532-q923xxn2	22	17	and	and	CC
cord-261532-q923xxn2	22	18	cytotoxic	cytotoxic	JJ
cord-261532-q923xxn2	22	19	T	t	NN
cord-261532-q923xxn2	22	20	-	-	HYPH
cord-261532-q923xxn2	22	21	cell	cell	NN
cord-261532-q923xxn2	22	22	activity	activity	NN
cord-261532-q923xxn2	23	1	(	(	-LRB-
cord-261532-q923xxn2	23	2	Hebenstreit	Hebenstreit	NNP
cord-261532-q923xxn2	23	3	et	et	NNP
cord-261532-q923xxn2	23	4	al	al	NNP
cord-261532-q923xxn2	23	5	.	.	NNP
cord-261532-q923xxn2	23	6	,	,	,
cord-261532-q923xxn2	23	7	2006	2006	CD
cord-261532-q923xxn2	23	8	)	)	-RRB-
cord-261532-q923xxn2	23	9	.	.	.
cord-261532-q923xxn2	24	1	It	-PRON-	PRP
cord-261532-q923xxn2	24	2	is	be	VBZ
cord-261532-q923xxn2	24	3	amazing	amazing	JJ
cord-261532-q923xxn2	24	4	that	that	IN
cord-261532-q923xxn2	24	5	such	such	PDT
cord-261532-q923xxn2	24	6	a	a	DT
cord-261532-q923xxn2	24	7	complicated	complicated	JJ
cord-261532-q923xxn2	24	8	signal	signal	NN
cord-261532-q923xxn2	24	9	network	network	NN
cord-261532-q923xxn2	24	10	is	be	VBZ
cord-261532-q923xxn2	24	11	exquisitely	exquisitely	RB
cord-261532-q923xxn2	24	12	regulated	regulate	VBN
cord-261532-q923xxn2	24	13	through	through	IN
cord-261532-q923xxn2	24	14	only	only	RB
cord-261532-q923xxn2	24	15	a	a	DT
cord-261532-q923xxn2	24	16	few	few	JJ
cord-261532-q923xxn2	24	17	adaptors	adaptor	NNS
cord-261532-q923xxn2	24	18	,	,	,
cord-261532-q923xxn2	24	19	which	which	WDT
cord-261532-q923xxn2	24	20	properly	properly	RB
cord-261532-q923xxn2	24	21	reflects	reflect	VBZ
cord-261532-q923xxn2	24	22	the	the	DT
cord-261532-q923xxn2	24	23	essential	essential	JJ
cord-261532-q923xxn2	24	24	roles	role	NNS
cord-261532-q923xxn2	24	25	of	of	IN
cord-261532-q923xxn2	24	26	these	these	DT
cord-261532-q923xxn2	24	27	molecules	molecule	NNS
cord-261532-q923xxn2	24	28	.	.	.
cord-261532-q923xxn2	25	1	In	in	IN
cord-261532-q923xxn2	25	2	this	this	DT
cord-261532-q923xxn2	25	3	review	review	NN
cord-261532-q923xxn2	25	4	,	,	,
cord-261532-q923xxn2	25	5	we	-PRON-	PRP
cord-261532-q923xxn2	25	6	summarize	summarize	VBP
cord-261532-q923xxn2	25	7	the	the	DT
cord-261532-q923xxn2	25	8	signaling	signal	VBG
cord-261532-q923xxn2	25	9	pathways	pathway	NNS
cord-261532-q923xxn2	25	10	mediated	mediate	VBN
cord-261532-q923xxn2	25	11	by	by	IN
cord-261532-q923xxn2	25	12	such	such	JJ
cord-261532-q923xxn2	25	13	essential	essential	JJ
cord-261532-q923xxn2	25	14	adaptors	adaptor	NNS
cord-261532-q923xxn2	25	15	,	,	,
cord-261532-q923xxn2	25	16	and	and	CC
cord-261532-q923xxn2	25	17	focus	focus	VB
cord-261532-q923xxn2	25	18	on	on	IN
cord-261532-q923xxn2	25	19	the	the	DT
cord-261532-q923xxn2	25	20	most	most	RBS
cord-261532-q923xxn2	25	21	recent	recent	JJ
cord-261532-q923xxn2	25	22	findings	finding	NNS
cord-261532-q923xxn2	25	23	regarding	regard	VBG
cord-261532-q923xxn2	25	24	the	the	DT
cord-261532-q923xxn2	25	25	interplay	interplay	NN
cord-261532-q923xxn2	25	26	between	between	IN
cord-261532-q923xxn2	25	27	STAT6	STAT6	NNS
cord-261532-q923xxn2	25	28	and	and	CC
cord-261532-q923xxn2	25	29	the	the	DT
cord-261532-q923xxn2	25	30	adaptor	adaptor	NN
cord-261532-q923xxn2	25	31	STING	sting	NN
cord-261532-q923xxn2	25	32	.	.	.
cord-261532-q923xxn2	26	1	MyD88	MyD88	NNP
cord-261532-q923xxn2	26	2	consists	consist	VBZ
cord-261532-q923xxn2	26	3	of	of	IN
cord-261532-q923xxn2	26	4	a	a	DT
cord-261532-q923xxn2	26	5	death	death	NN
cord-261532-q923xxn2	26	6	domain	domain	NN
cord-261532-q923xxn2	26	7	(	(	-LRB-
cord-261532-q923xxn2	26	8	DD	DD	NNP
cord-261532-q923xxn2	26	9	)	)	-RRB-
cord-261532-q923xxn2	26	10	and	and	CC
cord-261532-q923xxn2	26	11	a	a	DT
cord-261532-q923xxn2	26	12	TIR	TIR	NNP
cord-261532-q923xxn2	26	13	domain	domain	NN
cord-261532-q923xxn2	26	14	(	(	-LRB-
cord-261532-q923xxn2	26	15	Vogel	Vogel	NNP
cord-261532-q923xxn2	26	16	et	et	NNP
cord-261532-q923xxn2	26	17	al	al	NNP
cord-261532-q923xxn2	26	18	.	.	NNP
cord-261532-q923xxn2	26	19	,	,	,
cord-261532-q923xxn2	26	20	2003	2003	CD
cord-261532-q923xxn2	26	21	)	)	-RRB-
cord-261532-q923xxn2	26	22	.	.	.
cord-261532-q923xxn2	27	1	It	-PRON-	PRP
cord-261532-q923xxn2	27	2	is	be	VBZ
cord-261532-q923xxn2	27	3	crucial	crucial	JJ
cord-261532-q923xxn2	27	4	for	for	IN
cord-261532-q923xxn2	27	5	the	the	DT
cord-261532-q923xxn2	27	6	proper	proper	JJ
cord-261532-q923xxn2	27	7	responses	response	NNS
cord-261532-q923xxn2	27	8	of	of	IN
cord-261532-q923xxn2	27	9	IL-1	IL-1	NNP
cord-261532-q923xxn2	27	10	,	,	,
cord-261532-q923xxn2	27	11	IL-18	IL-18	NNP
cord-261532-q923xxn2	27	12	and	and	CC
cord-261532-q923xxn2	27	13	nearly	nearly	RB
cord-261532-q923xxn2	27	14	all	all	DT
cord-261532-q923xxn2	27	15	TLRs	tlr	NNS
cord-261532-q923xxn2	27	16	except	except	IN
cord-261532-q923xxn2	27	17	TLR3	TLR3	NNP
cord-261532-q923xxn2	27	18	in	in	IN
cord-261532-q923xxn2	27	19	the	the	DT
cord-261532-q923xxn2	27	20	activation	activation	NN
cord-261532-q923xxn2	27	21	of	of	IN
cord-261532-q923xxn2	27	22	transcription	transcription	NN
cord-261532-q923xxn2	27	23	factors	factor	NNS
cord-261532-q923xxn2	28	1	NF	nf	NN
cord-261532-q923xxn2	28	2	-	-	HYPH
cord-261532-q923xxn2	28	3	κB	κB	NNP
cord-261532-q923xxn2	28	4	and	and	CC
cord-261532-q923xxn2	28	5	AP-1	AP-1	NNP
cord-261532-q923xxn2	28	6	followed	follow	VBD
cord-261532-q923xxn2	28	7	by	by	IN
cord-261532-q923xxn2	28	8	the	the	DT
cord-261532-q923xxn2	28	9	induction	induction	NN
cord-261532-q923xxn2	28	10	of	of	IN
cord-261532-q923xxn2	28	11	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	28	12	genes	gene	NNS
cord-261532-q923xxn2	28	13	.	.	.
cord-261532-q923xxn2	29	1	In	in	IN
cord-261532-q923xxn2	29	2	addition	addition	NN
cord-261532-q923xxn2	29	3	,	,	,
cord-261532-q923xxn2	29	4	MyD88-dependent	MyD88-dependent	NNP
cord-261532-q923xxn2	29	5	signaling	signal	VBG
cord-261532-q923xxn2	29	6	downstream	downstream	NN
cord-261532-q923xxn2	29	7	of	of	IN
cord-261532-q923xxn2	29	8	TLR7	TLR7	NNP
cord-261532-q923xxn2	29	9	and	and	CC
cord-261532-q923xxn2	29	10	TLR9	TLR9	NNP
cord-261532-q923xxn2	29	11	elicits	elicit	VBZ
cord-261532-q923xxn2	29	12	the	the	DT
cord-261532-q923xxn2	29	13	production	production	NN
cord-261532-q923xxn2	29	14	of	of	IN
cord-261532-q923xxn2	29	15	IFN	IFN	NNP
cord-261532-q923xxn2	29	16	-	-	HYPH
cord-261532-q923xxn2	29	17	α	α	NNP
cord-261532-q923xxn2	29	18	and	and	CC
cord-261532-q923xxn2	29	19	IFN	IFN	NNP
cord-261532-q923xxn2	29	20	-	-	HYPH
cord-261532-q923xxn2	29	21	β1	β1	NNP
cord-261532-q923xxn2	29	22	through	through	IN
cord-261532-q923xxn2	29	23	the	the	DT
cord-261532-q923xxn2	29	24	activation	activation	NN
cord-261532-q923xxn2	29	25	of	of	IN
cord-261532-q923xxn2	29	26	IRF7	IRF7	NNP
cord-261532-q923xxn2	29	27	and/or	and/or	CC
cord-261532-q923xxn2	29	28	IRF1	IRF1	NNP
cord-261532-q923xxn2	29	29	(	(	-LRB-
cord-261532-q923xxn2	29	30	Fig	Fig	NNP
cord-261532-q923xxn2	29	31	.	.	.
cord-261532-q923xxn2	29	32	1	1	CD
cord-261532-q923xxn2	29	33	)	)	-RRB-
cord-261532-q923xxn2	30	1	(	(	-LRB-
cord-261532-q923xxn2	30	2	Watters	Watters	NNP
cord-261532-q923xxn2	30	3	et	et	NNP
cord-261532-q923xxn2	30	4	al	al	NNP
cord-261532-q923xxn2	30	5	.	.	NNP
cord-261532-q923xxn2	30	6	,	,	,
cord-261532-q923xxn2	30	7	2007	2007	CD
cord-261532-q923xxn2	31	1	;	;	:
cord-261532-q923xxn2	31	2	Kumar	Kumar	NNP
cord-261532-q923xxn2	31	3	et	et	NNP
cord-261532-q923xxn2	31	4	al	al	NNP
cord-261532-q923xxn2	31	5	.	.	NNP
cord-261532-q923xxn2	31	6	,	,	,
cord-261532-q923xxn2	31	7	2011	2011	CD
cord-261532-q923xxn2	31	8	)	)	-RRB-
cord-261532-q923xxn2	31	9	.	.	.
cord-261532-q923xxn2	32	1	In	in	IN
cord-261532-q923xxn2	32	2	most	most	JJS
cord-261532-q923xxn2	32	3	cases	case	NNS
cord-261532-q923xxn2	32	4	,	,	,
cord-261532-q923xxn2	32	5	the	the	DT
cord-261532-q923xxn2	32	6	receptors	receptor	NNS
cord-261532-q923xxn2	32	7	associate	associate	VBP
cord-261532-q923xxn2	32	8	with	with	IN
cord-261532-q923xxn2	32	9	MyD88	MyD88	NNS
cord-261532-q923xxn2	32	10	through	through	IN
cord-261532-q923xxn2	32	11	homotypic	homotypic	JJ
cord-261532-q923xxn2	32	12	interactions	interaction	NNS
cord-261532-q923xxn2	32	13	between	between	IN
cord-261532-q923xxn2	32	14	their	-PRON-	PRP$
cord-261532-q923xxn2	32	15	respective	respective	JJ
cord-261532-q923xxn2	32	16	TIR	TIR	NNP
cord-261532-q923xxn2	32	17	domains	domain	NNS
cord-261532-q923xxn2	32	18	,	,	,
cord-261532-q923xxn2	32	19	with	with	IN
cord-261532-q923xxn2	32	20	the	the	DT
cord-261532-q923xxn2	32	21	aid	aid	NN
cord-261532-q923xxn2	32	22	of	of	IN
cord-261532-q923xxn2	32	23	TIR	TIR	NNP
cord-261532-q923xxn2	32	24	domain	domain	NN
cord-261532-q923xxn2	32	25	-	-	HYPH
cord-261532-q923xxn2	32	26	containing	contain	VBG
cord-261532-q923xxn2	32	27	adaptor	adaptor	NN
cord-261532-q923xxn2	32	28	protein	protein	NN
cord-261532-q923xxn2	32	29	(	(	-LRB-
cord-261532-q923xxn2	32	30	TIRAP)/MyD88	tirap)/myd88	JJ
cord-261532-q923xxn2	32	31	adaptor	adaptor	NN
cord-261532-q923xxn2	32	32	-	-	HYPH
cord-261532-q923xxn2	32	33	like	like	JJ
cord-261532-q923xxn2	32	34	(	(	-LRB-
cord-261532-q923xxn2	32	35	Mal	Mal	NNP
cord-261532-q923xxn2	32	36	)	)	-RRB-
cord-261532-q923xxn2	32	37	in	in	IN
cord-261532-q923xxn2	32	38	case	case	NN
cord-261532-q923xxn2	32	39	of	of	IN
cord-261532-q923xxn2	32	40	TLR2	TLR2	NNP
cord-261532-q923xxn2	32	41	and	and	CC
cord-261532-q923xxn2	32	42	TLR4	TLR4	NNP
cord-261532-q923xxn2	32	43	.	.	.
cord-261532-q923xxn2	33	1	This	this	DT
cord-261532-q923xxn2	33	2	interaction	interaction	NN
cord-261532-q923xxn2	33	3	allows	allow	VBZ
cord-261532-q923xxn2	33	4	MyD88	MyD88	NNS
cord-261532-q923xxn2	33	5	to	to	TO
cord-261532-q923xxn2	33	6	recruit	recruit	VB
cord-261532-q923xxn2	33	7	IL-1R	IL-1R	NNP
cord-261532-q923xxn2	33	8	-	-	HYPH
cord-261532-q923xxn2	33	9	associated	associate	VBN
cord-261532-q923xxn2	33	10	kinase	kinase	NN
cord-261532-q923xxn2	33	11	(	(	-LRB-
cord-261532-q923xxn2	33	12	IRAK	IRAK	NNP
cord-261532-q923xxn2	33	13	)	)	-RRB-
cord-261532-q923xxn2	33	14	family	family	NN
cord-261532-q923xxn2	33	15	(	(	-LRB-
cord-261532-q923xxn2	33	16	IRAK4	IRAK4	NNP
cord-261532-q923xxn2	33	17	,	,	,
cord-261532-q923xxn2	33	18	IRAK1	IRAK1	NNP
cord-261532-q923xxn2	33	19	and	and	CC
cord-261532-q923xxn2	33	20	IRAK2	IRAK2	NNP
cord-261532-q923xxn2	33	21	)	)	-RRB-
cord-261532-q923xxn2	34	1	via	via	IN
cord-261532-q923xxn2	34	2	DD	DD	NNP
cord-261532-q923xxn2	34	3	interaction	interaction	NN
cord-261532-q923xxn2	34	4	(	(	-LRB-
cord-261532-q923xxn2	34	5	Cao	Cao	NNP
cord-261532-q923xxn2	34	6	et	et	NNP
cord-261532-q923xxn2	34	7	al	al	NNP
cord-261532-q923xxn2	34	8	.	.	NNP
cord-261532-q923xxn2	34	9	,	,	,
cord-261532-q923xxn2	34	10	1996	1996	CD
cord-261532-q923xxn2	34	11	;	;	:
cord-261532-q923xxn2	34	12	Marta	Marta	NNP
cord-261532-q923xxn2	34	13	et	et	NNP
cord-261532-q923xxn2	34	14	al	al	NNP
cord-261532-q923xxn2	34	15	.	.	NNP
cord-261532-q923xxn2	34	16	,	,	,
cord-261532-q923xxn2	34	17	1997	1997	CD
cord-261532-q923xxn2	34	18	)	)	-RRB-
cord-261532-q923xxn2	34	19	.	.	.
cord-261532-q923xxn2	35	1	IRAK1	IRAK1	NNP
cord-261532-q923xxn2	35	2	is	be	VBZ
cord-261532-q923xxn2	35	3	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	35	4	by	by	IN
cord-261532-q923xxn2	35	5	IRAK4	IRAK4	NNP
cord-261532-q923xxn2	35	6	and	and	CC
cord-261532-q923xxn2	35	7	,	,	,
cord-261532-q923xxn2	35	8	after	after	IN
cord-261532-q923xxn2	35	9	separated	separate	VBN
cord-261532-q923xxn2	35	10	from	from	IN
cord-261532-q923xxn2	35	11	MyD88	MyD88	NNP
cord-261532-q923xxn2	35	12	,	,	,
cord-261532-q923xxn2	35	13	interacts	interact	VBZ
cord-261532-q923xxn2	35	14	with	with	IN
cord-261532-q923xxn2	35	15	tumor	tumor	NN
cord-261532-q923xxn2	35	16	necrosis	necrosis	NN
cord-261532-q923xxn2	35	17	factor	factor	NN
cord-261532-q923xxn2	35	18	(	(	-LRB-
cord-261532-q923xxn2	35	19	TNF)R	TNF)R	NNP
cord-261532-q923xxn2	35	20	-	-	HYPH
cord-261532-q923xxn2	35	21	associated	associate	VBN
cord-261532-q923xxn2	35	22	factor	factor	NN
cord-261532-q923xxn2	35	23	6	6	CD
cord-261532-q923xxn2	35	24	(	(	-LRB-
cord-261532-q923xxn2	35	25	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	35	26	)	)	-RRB-
cord-261532-q923xxn2	35	27	,	,	,
cord-261532-q923xxn2	35	28	an	an	DT
cord-261532-q923xxn2	35	29	E3	e3	NN
cord-261532-q923xxn2	35	30	ubiquitin	ubiquitin	NN
cord-261532-q923xxn2	35	31	ligase	ligase	NN
cord-261532-q923xxn2	35	32	that	that	WDT
cord-261532-q923xxn2	35	33	functions	function	VBZ
cord-261532-q923xxn2	35	34	together	together	RB
cord-261532-q923xxn2	35	35	with	with	IN
cord-261532-q923xxn2	35	36	the	the	DT
cord-261532-q923xxn2	35	37	Ubc13	Ubc13	NNP
cord-261532-q923xxn2	35	38	/	/	SYM
cord-261532-q923xxn2	35	39	Uev1A	uev1a	NN
cord-261532-q923xxn2	35	40	complex	complex	JJ
cord-261532-q923xxn2	35	41	to	to	TO
cord-261532-q923xxn2	35	42	generate	generate	VB
cord-261532-q923xxn2	35	43	dissociative	dissociative	JJ
cord-261532-q923xxn2	35	44	lysine-63	lysine-63	NN
cord-261532-q923xxn2	35	45	(	(	-LRB-
cord-261532-q923xxn2	35	46	K	K	NNP
cord-261532-q923xxn2	35	47	63	63	CD
cord-261532-q923xxn2	35	48	)	)	-RRB-
cord-261532-q923xxn2	36	1	-linked	-linked	JJ
cord-261532-q923xxn2	36	2	poly	poly	JJ
cord-261532-q923xxn2	36	3	-	-	HYPH
cord-261532-q923xxn2	36	4	ubiquitin	ubiquitin	JJ
cord-261532-q923xxn2	36	5	chains	chain	NNS
cord-261532-q923xxn2	36	6	(	(	-LRB-
cord-261532-q923xxn2	36	7	Horng	Horng	NNP
cord-261532-q923xxn2	36	8	et	et	NNP
cord-261532-q923xxn2	36	9	al	al	NNP
cord-261532-q923xxn2	36	10	.	.	NNP
cord-261532-q923xxn2	36	11	,	,	,
cord-261532-q923xxn2	36	12	2001	2001	CD
cord-261532-q923xxn2	36	13	)	)	-RRB-
cord-261532-q923xxn2	36	14	.	.	.
cord-261532-q923xxn2	37	1	Unanchored	Unanchored	NNP
cord-261532-q923xxn2	37	2	K	K	NNP
cord-261532-q923xxn2	37	3	63	63	CD
cord-261532-q923xxn2	37	4	poly	poly	JJ
cord-261532-q923xxn2	37	5	-	-	HYPH
cord-261532-q923xxn2	37	6	ubiquitin	ubiquitin	JJ
cord-261532-q923xxn2	37	7	chains	chain	NNS
cord-261532-q923xxn2	37	8	bind	bind	VBP
cord-261532-q923xxn2	37	9	and	and	CC
cord-261532-q923xxn2	37	10	activate	activate	VBP
cord-261532-q923xxn2	37	11	a	a	DT
cord-261532-q923xxn2	37	12	complex	complex	JJ
cord-261532-q923xxn2	37	13	comprising	comprise	VBG
cord-261532-q923xxn2	37	14	transforming	transform	VBG
cord-261532-q923xxn2	37	15	growth	growth	NN
cord-261532-q923xxn2	37	16	factor	factor	NN
cord-261532-q923xxn2	37	17	β	β	NN
cord-261532-q923xxn2	37	18	(	(	-LRB-
cord-261532-q923xxn2	37	19	TGF	TGF	NNP
cord-261532-q923xxn2	37	20	-	-	HYPH
cord-261532-q923xxn2	37	21	β)-activated	β)-activate	VBN
cord-261532-q923xxn2	37	22	kinase	kinase	NN
cord-261532-q923xxn2	37	23	1	1	CD
cord-261532-q923xxn2	37	24	(	(	-LRB-
cord-261532-q923xxn2	37	25	TAK1	TAK1	NNP
cord-261532-q923xxn2	37	26	)	)	-RRB-
cord-261532-q923xxn2	37	27	and	and	CC
cord-261532-q923xxn2	37	28	TAK1-binding	tak1-binding	NN
cord-261532-q923xxn2	37	29	proteins	protein	NNS
cord-261532-q923xxn2	37	30	(	(	-LRB-
cord-261532-q923xxn2	37	31	TAB1	TAB1	NNP
cord-261532-q923xxn2	37	32	,	,	,
cord-261532-q923xxn2	37	33	-2	-2	NNP
cord-261532-q923xxn2	37	34	and	and	CC
cord-261532-q923xxn2	37	35	-3	-3	NNP
cord-261532-q923xxn2	37	36	)	)	-RRB-
cord-261532-q923xxn2	37	37	to	to	TO
cord-261532-q923xxn2	37	38	phosphorylate	phosphorylate	VB
cord-261532-q923xxn2	37	39	inhibitor	inhibitor	NN
cord-261532-q923xxn2	37	40	of	of	IN
cord-261532-q923xxn2	37	41	kappaB	kappaB	NNP
cord-261532-q923xxn2	37	42	kinase	kinase	NN
cord-261532-q923xxn2	37	43	beta	beta	NN
cord-261532-q923xxn2	37	44	(	(	-LRB-
cord-261532-q923xxn2	37	45	IKBKB	IKBKB	NNP
cord-261532-q923xxn2	37	46	or	or	CC
cord-261532-q923xxn2	37	47	IKKβ	IKKβ	NNP
cord-261532-q923xxn2	37	48	)	)	-RRB-
cord-261532-q923xxn2	37	49	and	and	CC
cord-261532-q923xxn2	38	1	mitogen	mitogen	NNP
cord-261532-q923xxn2	38	2	-	-	HYPH
cord-261532-q923xxn2	38	3	activated	activate	VBN
cord-261532-q923xxn2	38	4	protein	protein	NN
cord-261532-q923xxn2	38	5	kinase	kinase	NN
cord-261532-q923xxn2	38	6	kinase	kinase	VBZ
cord-261532-q923xxn2	38	7	6	6	CD
cord-261532-q923xxn2	38	8	(	(	-LRB-
cord-261532-q923xxn2	38	9	MAP2K6	MAP2K6	NNS
cord-261532-q923xxn2	38	10	or	or	CC
cord-261532-q923xxn2	38	11	MKK6	MKK6	NNP
cord-261532-q923xxn2	38	12	)	)	-RRB-
cord-261532-q923xxn2	39	1	(	(	-LRB-
cord-261532-q923xxn2	39	2	Wang	Wang	NNP
cord-261532-q923xxn2	39	3	et	et	NNP
cord-261532-q923xxn2	39	4	al	al	NNP
cord-261532-q923xxn2	39	5	.	.	NNP
cord-261532-q923xxn2	39	6	,	,	,
cord-261532-q923xxn2	39	7	2001	2001	CD
cord-261532-q923xxn2	39	8	)	)	-RRB-
cord-261532-q923xxn2	39	9	.	.	.
cord-261532-q923xxn2	40	1	Then	then	RB
cord-261532-q923xxn2	40	2	the	the	DT
cord-261532-q923xxn2	40	3	IKK	IKK	NNP
cord-261532-q923xxn2	40	4	complex	complex	NN
cord-261532-q923xxn2	40	5	,	,	,
cord-261532-q923xxn2	40	6	made	make	VBN
cord-261532-q923xxn2	40	7	up	up	RP
cord-261532-q923xxn2	40	8	of	of	IN
cord-261532-q923xxn2	40	9	IKK	IKK	NNP
cord-261532-q923xxn2	40	10	-	-	HYPH
cord-261532-q923xxn2	40	11	α	α	NNP
cord-261532-q923xxn2	40	12	,	,	,
cord-261532-q923xxn2	40	13	IKK	IKK	NNP
cord-261532-q923xxn2	40	14	-	-	HYPH
cord-261532-q923xxn2	40	15	β	β	NNP
cord-261532-q923xxn2	40	16	and	and	CC
cord-261532-q923xxn2	40	17	NF	NF	NNP
cord-261532-q923xxn2	40	18	-	-	HYPH
cord-261532-q923xxn2	40	19	κB	κb	CD
cord-261532-q923xxn2	40	20	essential	essential	JJ
cord-261532-q923xxn2	40	21	modulator	modulator	NN
cord-261532-q923xxn2	40	22	(	(	-LRB-
cord-261532-q923xxn2	40	23	NEMO	NEMO	NNP
cord-261532-q923xxn2	40	24	)	)	-RRB-
cord-261532-q923xxn2	40	25	,	,	,
cord-261532-q923xxn2	40	26	phosphorylates	phosphorylate	VBZ
cord-261532-q923xxn2	40	27	IκBα	IκBα	NNP
cord-261532-q923xxn2	40	28	,	,	,
cord-261532-q923xxn2	40	29	leading	lead	VBG
cord-261532-q923xxn2	40	30	to	to	IN
cord-261532-q923xxn2	40	31	its	-PRON-	PRP$
cord-261532-q923xxn2	40	32	degradation	degradation	NN
cord-261532-q923xxn2	40	33	by	by	IN
cord-261532-q923xxn2	40	34	the	the	DT
cord-261532-q923xxn2	40	35	proteasome	proteasome	NN
cord-261532-q923xxn2	40	36	and	and	CC
cord-261532-q923xxn2	40	37	the	the	DT
cord-261532-q923xxn2	40	38	release	release	NN
cord-261532-q923xxn2	40	39	of	of	IN
cord-261532-q923xxn2	40	40	NF	nf	NN
cord-261532-q923xxn2	40	41	-	-	HYPH
cord-261532-q923xxn2	40	42	κB	κB	NNP
cord-261532-q923xxn2	40	43	,	,	,
cord-261532-q923xxn2	40	44	while	while	IN
cord-261532-q923xxn2	40	45	phosphorylated	phosphorylated	JJ
cord-261532-q923xxn2	40	46	MKK6	MKK6	NNP
cord-261532-q923xxn2	40	47	activates	activate	VBZ
cord-261532-q923xxn2	40	48	MAPKs	mapk	NNS
cord-261532-q923xxn2	40	49	including	include	VBG
cord-261532-q923xxn2	40	50	c	c	NN
cord-261532-q923xxn2	40	51	-	-	:
cord-261532-q923xxn2	40	52	Jun	Jun	NNP
cord-261532-q923xxn2	40	53	N	N	NNP
cord-261532-q923xxn2	40	54	-	-	HYPH
cord-261532-q923xxn2	40	55	terminal	terminal	NN
cord-261532-q923xxn2	40	56	kinase	kinase	NN
cord-261532-q923xxn2	40	57	1/2	1/2	CD
cord-261532-q923xxn2	40	58	(	(	-LRB-
cord-261532-q923xxn2	40	59	JNK1/2	JNK1/2	NNP
cord-261532-q923xxn2	40	60	)	)	-RRB-
cord-261532-q923xxn2	40	61	,	,	.
cord-261532-q923xxn2	41	1	p38	p38	JJ
cord-261532-q923xxn2	41	2	and	and	CC
cord-261532-q923xxn2	41	3	extracellular	extracellular	JJ
cord-261532-q923xxn2	41	4	signal	signal	NN
cord-261532-q923xxn2	41	5	-	-	HYPH
cord-261532-q923xxn2	41	6	regulated	regulate	VBN
cord-261532-q923xxn2	41	7	kinase	kinase	NN
cord-261532-q923xxn2	41	8	1/2	1/2	CD
cord-261532-q923xxn2	41	9	(	(	-LRB-
cord-261532-q923xxn2	41	10	ERK1/2	ERK1/2	NNP
cord-261532-q923xxn2	41	11	)	)	-RRB-
cord-261532-q923xxn2	42	1	to	to	TO
cord-261532-q923xxn2	42	2	stimulate	stimulate	VB
cord-261532-q923xxn2	42	3	AP-1	AP-1	NNP
cord-261532-q923xxn2	42	4	activity	activity	NN
cord-261532-q923xxn2	42	5	.	.	.
cord-261532-q923xxn2	43	1	Active	active	JJ
cord-261532-q923xxn2	43	2	NF	nf	NN
cord-261532-q923xxn2	43	3	-	-	HYPH
cord-261532-q923xxn2	43	4	κB	κB	NNP
cord-261532-q923xxn2	43	5	and	and	CC
cord-261532-q923xxn2	43	6	AP-1	AP-1	NNP
cord-261532-q923xxn2	43	7	translocate	translocate	VBP
cord-261532-q923xxn2	43	8	to	to	IN
cord-261532-q923xxn2	43	9	the	the	DT
cord-261532-q923xxn2	43	10	nucleus	nucleus	NN
cord-261532-q923xxn2	43	11	to	to	TO
cord-261532-q923xxn2	43	12	turn	turn	VB
cord-261532-q923xxn2	43	13	on	on	RP
cord-261532-q923xxn2	43	14	the	the	DT
cord-261532-q923xxn2	43	15	expression	expression	NN
cord-261532-q923xxn2	43	16	of	of	IN
cord-261532-q923xxn2	43	17	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	43	18	cytokines	cytokine	NNS
cord-261532-q923xxn2	43	19	.	.	.
cord-261532-q923xxn2	44	1	Individually	individually	RB
cord-261532-q923xxn2	44	2	,	,	,
cord-261532-q923xxn2	44	3	TLR7	TLR7	NNP
cord-261532-q923xxn2	44	4	and	and	CC
cord-261532-q923xxn2	44	5	TLR9	TLR9	NNP
cord-261532-q923xxn2	44	6	recruit	recruit	NN
cord-261532-q923xxn2	44	7	MyD88	MyD88	NNS
cord-261532-q923xxn2	44	8	followed	follow	VBN
cord-261532-q923xxn2	44	9	by	by	IN
cord-261532-q923xxn2	44	10	the	the	DT
cord-261532-q923xxn2	44	11	formation	formation	NN
cord-261532-q923xxn2	44	12	of	of	IN
cord-261532-q923xxn2	44	13	a	a	DT
cord-261532-q923xxn2	44	14	complex	complex	JJ
cord-261532-q923xxn2	44	15	containing	contain	VBG
cord-261532-q923xxn2	44	16	IRAK1	IRAK1	NNP
cord-261532-q923xxn2	44	17	,	,	,
cord-261532-q923xxn2	44	18	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	44	19	,	,	,
cord-261532-q923xxn2	44	20	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	44	21	,	,	,
cord-261532-q923xxn2	44	22	IKK	IKK	NNP
cord-261532-q923xxn2	44	23	-	-	HYPH
cord-261532-q923xxn2	44	24	α	α	NNP
cord-261532-q923xxn2	44	25	and	and	CC
cord-261532-q923xxn2	44	26	 	 	_SP
cord-261532-q923xxn2	44	27	IRF7	IRF7	NNP
cord-261532-q923xxn2	44	28	/	/	SYM
cord-261532-q923xxn2	44	29	IRF1	IRF1	NNP
cord-261532-q923xxn2	44	30	,	,	,
cord-261532-q923xxn2	44	31	which	which	WDT
cord-261532-q923xxn2	44	32	results	result	VBZ
cord-261532-q923xxn2	44	33	in	in	IN
cord-261532-q923xxn2	44	34	the	the	DT
cord-261532-q923xxn2	44	35	production	production	NN
cord-261532-q923xxn2	44	36	of	of	IN
cord-261532-q923xxn2	44	37	type	type	NN
cord-261532-q923xxn2	44	38	I	-PRON-	PRP
cord-261532-q923xxn2	44	39	interferons	interferon	NNS
cord-261532-q923xxn2	45	1	(	(	-LRB-
cord-261532-q923xxn2	45	2	Brown	Brown	NNP
cord-261532-q923xxn2	45	3	et	et	NNP
cord-261532-q923xxn2	45	4	al	al	NNP
cord-261532-q923xxn2	45	5	.	.	NNP
cord-261532-q923xxn2	45	6	,	,	,
cord-261532-q923xxn2	45	7	2011	2011	CD
cord-261532-q923xxn2	45	8	)	)	-RRB-
cord-261532-q923xxn2	45	9	.	.	.
cord-261532-q923xxn2	46	1	MyD88	MyD88	NNS
cord-261532-q923xxn2	46	2	also	also	RB
cord-261532-q923xxn2	46	3	recruits	recruit	VBZ
cord-261532-q923xxn2	46	4	IRF5	IRF5	NNP
cord-261532-q923xxn2	46	5	and	and	CC
cord-261532-q923xxn2	46	6	triggers	trigger	VBZ
cord-261532-q923xxn2	46	7	a	a	DT
cord-261532-q923xxn2	46	8	TRAF6	traf6	NN
cord-261532-q923xxn2	46	9	signaling	signal	VBG
cord-261532-q923xxn2	46	10	pathway	pathway	NN
cord-261532-q923xxn2	46	11	that	that	WDT
cord-261532-q923xxn2	46	12	leads	lead	VBZ
cord-261532-q923xxn2	46	13	to	to	IN
cord-261532-q923xxn2	46	14	the	the	DT
cord-261532-q923xxn2	46	15	activation	activation	NN
cord-261532-q923xxn2	46	16	of	of	IN
cord-261532-q923xxn2	46	17	NF	NF	NNP
cord-261532-q923xxn2	46	18	-	-	HYPH
cord-261532-q923xxn2	46	19	κB	κB	NNP
cord-261532-q923xxn2	46	20	,	,	,
cord-261532-q923xxn2	46	21	where	where	WRB
cord-261532-q923xxn2	46	22	IRF4	IRF4	NNP
cord-261532-q923xxn2	46	23	competes	compete	VBZ
cord-261532-q923xxn2	46	24	with	with	IN
cord-261532-q923xxn2	46	25	IRF5	IRF5	NNP
cord-261532-q923xxn2	46	26	for	for	IN
cord-261532-q923xxn2	46	27	MyD88	MyD88	NNS
cord-261532-q923xxn2	46	28	binding	binding	NN
cord-261532-q923xxn2	46	29	(	(	-LRB-
cord-261532-q923xxn2	46	30	Chen	Chen	NNP
cord-261532-q923xxn2	46	31	,	,	,
cord-261532-q923xxn2	46	32	2005	2005	CD
cord-261532-q923xxn2	46	33	;	;	:
cord-261532-q923xxn2	47	1	Lee	Lee	NNP
cord-261532-q923xxn2	47	2	and	and	CC
cord-261532-q923xxn2	47	3	Kim	Kim	NNP
cord-261532-q923xxn2	47	4	et	et	NNP
cord-261532-q923xxn2	47	5	al	al	NNP
cord-261532-q923xxn2	47	6	.	.	NNP
cord-261532-q923xxn2	47	7	,	,	,
cord-261532-q923xxn2	47	8	2007	2007	CD
cord-261532-q923xxn2	47	9	)	)	-RRB-
cord-261532-q923xxn2	47	10	.	.	.
cord-261532-q923xxn2	48	1	The	the	DT
cord-261532-q923xxn2	48	2	fact	fact	NN
cord-261532-q923xxn2	48	3	that	that	IN
cord-261532-q923xxn2	48	4	LPS	LPS	NNP
cord-261532-q923xxn2	48	5	and	and	CC
cord-261532-q923xxn2	48	6	poly	poly	NNP
cord-261532-q923xxn2	48	7	(	(	-LRB-
cord-261532-q923xxn2	48	8	I	i	NN
cord-261532-q923xxn2	48	9	:	:	:
cord-261532-q923xxn2	48	10	C	C	NNP
cord-261532-q923xxn2	48	11	)	)	-RRB-
cord-261532-q923xxn2	48	12	(	(	-LRB-
cord-261532-q923xxn2	48	13	a	a	DT
cord-261532-q923xxn2	48	14	viral	viral	JJ
cord-261532-q923xxn2	48	15	dsRNA	dsrna	NN
cord-261532-q923xxn2	48	16	agonist	agonist	NN
cord-261532-q923xxn2	48	17	)	)	-RRB-
cord-261532-q923xxn2	48	18	is	be	VBZ
cord-261532-q923xxn2	48	19	still	still	RB
cord-261532-q923xxn2	48	20	capable	capable	JJ
cord-261532-q923xxn2	48	21	of	of	IN
cord-261532-q923xxn2	48	22	activating	activate	VBG
cord-261532-q923xxn2	48	23	NF	nf	NN
cord-261532-q923xxn2	48	24	-	-	HYPH
cord-261532-q923xxn2	48	25	κB	κB	NNP
cord-261532-q923xxn2	48	26	and	and	CC
cord-261532-q923xxn2	48	27	MKK6	MKK6	NNP
cord-261532-q923xxn2	48	28	in	in	IN
cord-261532-q923xxn2	48	29	MyD88-deficient	MyD88-deficient	NNP
cord-261532-q923xxn2	48	30	cells	cell	NNS
cord-261532-q923xxn2	48	31	indicates	indicate	VBZ
cord-261532-q923xxn2	48	32	the	the	DT
cord-261532-q923xxn2	48	33	existence	existence	NN
cord-261532-q923xxn2	48	34	of	of	IN
cord-261532-q923xxn2	48	35	a	a	DT
cord-261532-q923xxn2	48	36	MyD88-independent	MyD88-independent	NNP
cord-261532-q923xxn2	48	37	pathway	pathway	NN
cord-261532-q923xxn2	48	38	(	(	-LRB-
cord-261532-q923xxn2	48	39	Fig	Fig	NNP
cord-261532-q923xxn2	48	40	.	.	.
cord-261532-q923xxn2	48	41	1	1	CD
cord-261532-q923xxn2	48	42	)	)	-RRB-
cord-261532-q923xxn2	49	1	(	(	-LRB-
cord-261532-q923xxn2	49	2	Kawai	Kawai	NNP
cord-261532-q923xxn2	49	3	et	et	NNP
cord-261532-q923xxn2	49	4	al	al	NNP
cord-261532-q923xxn2	49	5	.	.	NNP
cord-261532-q923xxn2	49	6	,	,	,
cord-261532-q923xxn2	49	7	1999	1999	CD
cord-261532-q923xxn2	49	8	)	)	-RRB-
cord-261532-q923xxn2	49	9	.	.	.
cord-261532-q923xxn2	50	1	In	in	IN
cord-261532-q923xxn2	50	2	such	such	JJ
cord-261532-q923xxn2	50	3	contexts	context	NNS
cord-261532-q923xxn2	50	4	,	,	,
cord-261532-q923xxn2	50	5	TRIF	TRIF	NNP
cord-261532-q923xxn2	50	6	/	/	SYM
cord-261532-q923xxn2	50	7	TIR	TIR	NNP
cord-261532-q923xxn2	50	8	domain	domain	NN
cord-261532-q923xxn2	50	9	-	-	HYPH
cord-261532-q923xxn2	50	10	containing	contain	VBG
cord-261532-q923xxn2	50	11	adaptor	adaptor	NN
cord-261532-q923xxn2	50	12	molecule	molecule	NN
cord-261532-q923xxn2	50	13	1	1	CD
cord-261532-q923xxn2	50	14	(	(	-LRB-
cord-261532-q923xxn2	50	15	TICAM-1	TICAM-1	NNP
cord-261532-q923xxn2	50	16	)	)	-RRB-
cord-261532-q923xxn2	50	17	was	be	VBD
cord-261532-q923xxn2	50	18	found	find	VBN
cord-261532-q923xxn2	50	19	to	to	TO
cord-261532-q923xxn2	50	20	be	be	VB
cord-261532-q923xxn2	50	21	involved	involve	VBN
cord-261532-q923xxn2	50	22	in	in	IN
cord-261532-q923xxn2	50	23	the	the	DT
cord-261532-q923xxn2	50	24	MyD88-independent	MyD88-independent	NNP
cord-261532-q923xxn2	50	25	responses	response	NNS
cord-261532-q923xxn2	50	26	.	.	.
cord-261532-q923xxn2	51	1	TRIF	TRIF	NNP
cord-261532-q923xxn2	51	2	comprises	comprise	VBZ
cord-261532-q923xxn2	51	3	712	712	CD
cord-261532-q923xxn2	51	4	amino	amino	JJ
cord-261532-q923xxn2	51	5	acids	acid	NNS
cord-261532-q923xxn2	51	6	with	with	IN
cord-261532-q923xxn2	51	7	three	three	CD
cord-261532-q923xxn2	51	8	domains	domain	NNS
cord-261532-q923xxn2	51	9	:	:	:
cord-261532-q923xxn2	51	10	a	a	DT
cord-261532-q923xxn2	51	11	TRAF	TRAF	NNP
cord-261532-q923xxn2	51	12	binding	binding	NN
cord-261532-q923xxn2	51	13	domain	domain	NN
cord-261532-q923xxn2	51	14	,	,	,
cord-261532-q923xxn2	51	15	a	a	DT
cord-261532-q923xxn2	51	16	TIR	TIR	NNP
cord-261532-q923xxn2	51	17	domain	domain	NN
cord-261532-q923xxn2	51	18	and	and	CC
cord-261532-q923xxn2	51	19	a	a	DT
cord-261532-q923xxn2	51	20	C	c	NN
cord-261532-q923xxn2	51	21	-	-	HYPH
cord-261532-q923xxn2	51	22	terminal	terminal	NN
cord-261532-q923xxn2	51	23	RHIM	RHIM	NNP
cord-261532-q923xxn2	51	24	-receptor	-receptor	:
cord-261532-q923xxn2	51	25	-	-	HYPH
cord-261532-q923xxn2	51	26	interacting	interact	VBG
cord-261532-q923xxn2	51	27	protein	protein	NN
cord-261532-q923xxn2	51	28	(	(	-LRB-
cord-261532-q923xxn2	51	29	RIP	RIP	NNP
cord-261532-q923xxn2	51	30	)	)	-RRB-
cord-261532-q923xxn2	51	31	homotypic	homotypic	JJ
cord-261532-q923xxn2	51	32	interaction	interaction	NN
cord-261532-q923xxn2	51	33	motif	motif	NN
cord-261532-q923xxn2	51	34	-	-	:
cord-261532-q923xxn2	51	35	domain	domain	NN
cord-261532-q923xxn2	51	36	(	(	-LRB-
cord-261532-q923xxn2	51	37	Yamamoto	Yamamoto	NNP
cord-261532-q923xxn2	51	38	et	et	NNP
cord-261532-q923xxn2	51	39	al	al	NNP
cord-261532-q923xxn2	51	40	.	.	NNP
cord-261532-q923xxn2	51	41	,	,	,
cord-261532-q923xxn2	51	42	2003	2003	CD
cord-261532-q923xxn2	51	43	)	)	-RRB-
cord-261532-q923xxn2	51	44	.	.	.
cord-261532-q923xxn2	52	1	TLR3	TLR3	NNP
cord-261532-q923xxn2	52	2	directly	directly	RB
cord-261532-q923xxn2	52	3	interacts	interact	VBZ
cord-261532-q923xxn2	52	4	with	with	IN
cord-261532-q923xxn2	52	5	TRIF	TRIF	NNP
cord-261532-q923xxn2	52	6	,	,	,
cord-261532-q923xxn2	52	7	while	while	IN
cord-261532-q923xxn2	52	8	TLR4	TLR4	NNP
cord-261532-q923xxn2	52	9	recruits	recruit	VBZ
cord-261532-q923xxn2	52	10	TRIF	TRIF	NNP
cord-261532-q923xxn2	52	11	through	through	IN
cord-261532-q923xxn2	52	12	TRIF	TRIF	NNP
cord-261532-q923xxn2	52	13	-	-	HYPH
cord-261532-q923xxn2	52	14	related	relate	VBN
cord-261532-q923xxn2	52	15	adaptor	adaptor	NN
cord-261532-q923xxn2	52	16	molecule	molecule	NN
cord-261532-q923xxn2	52	17	(	(	-LRB-
cord-261532-q923xxn2	52	18	TRAM	tram	NN
cord-261532-q923xxn2	52	19	)	)	-RRB-
cord-261532-q923xxn2	52	20	.	.	.
cord-261532-q923xxn2	53	1	The	the	DT
cord-261532-q923xxn2	53	2	N	N	NNP
cord-261532-q923xxn2	53	3	-	-	HYPH
cord-261532-q923xxn2	53	4	terminus	terminus	NN
cord-261532-q923xxn2	53	5	of	of	IN
cord-261532-q923xxn2	53	6	TRIF	TRIF	NNP
cord-261532-q923xxn2	53	7	interacts	interact	VBZ
cord-261532-q923xxn2	53	8	with	with	IN
cord-261532-q923xxn2	53	9	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	53	10	and	and	CC
cord-261532-q923xxn2	53	11	TRAF6	traf6	RB
cord-261532-q923xxn2	53	12	while	while	IN
cord-261532-q923xxn2	53	13	its	-PRON-	PRP$
cord-261532-q923xxn2	53	14	C	c	NN
cord-261532-q923xxn2	53	15	-	-	HYPH
cord-261532-q923xxn2	53	16	terminal	terminal	JJ
cord-261532-q923xxn2	53	17	RHIM	RHIM	NNP
cord-261532-q923xxn2	53	18	domain	domain	NN
cord-261532-q923xxn2	53	19	recruits	recruit	VBZ
cord-261532-q923xxn2	53	20	RIP1	RIP1	NNP
cord-261532-q923xxn2	53	21	and	and	CC
cord-261532-q923xxn2	53	22	RIP3	RIP3	NNPS
cord-261532-q923xxn2	53	23	.	.	.
cord-261532-q923xxn2	54	1	As	as	IN
cord-261532-q923xxn2	54	2	an	an	DT
cord-261532-q923xxn2	54	3	E3	e3	NN
cord-261532-q923xxn2	54	4	ubiquitin	ubiquitin	NN
cord-261532-q923xxn2	54	5	ligase	ligase	NN
cord-261532-q923xxn2	54	6	,	,	,
cord-261532-q923xxn2	54	7	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	54	8	undergoes	undergo	VBZ
cord-261532-q923xxn2	54	9	K	K	NNP
cord-261532-q923xxn2	54	10	63	63	CD
cord-261532-q923xxn2	55	1	-linked	-linked	JJ
cord-261532-q923xxn2	55	2	self	self	NN
cord-261532-q923xxn2	55	3	-	-	HYPH
cord-261532-q923xxn2	55	4	ubiquitination	ubiquitination	NN
cord-261532-q923xxn2	55	5	to	to	TO
cord-261532-q923xxn2	55	6	activate	activate	VB
cord-261532-q923xxn2	55	7	TRAF	TRAF	NNP
cord-261532-q923xxn2	55	8	family	family	NN
cord-261532-q923xxn2	55	9	member	member	NN
cord-261532-q923xxn2	55	10	-	-	HYPH
cord-261532-q923xxn2	55	11	associated	associate	VBN
cord-261532-q923xxn2	55	12	NF	nf	NN
cord-261532-q923xxn2	55	13	-	-	HYPH
cord-261532-q923xxn2	55	14	κB	κb	CD
cord-261532-q923xxn2	55	15	activator	activator	NN
cord-261532-q923xxn2	55	16	(	(	-LRB-
cord-261532-q923xxn2	55	17	TANK)-binding	tank)-binde	VBG
cord-261532-q923xxn2	55	18	kinase-1	kinase-1	NNP
cord-261532-q923xxn2	55	19	(	(	-LRB-
cord-261532-q923xxn2	55	20	TBK1	TBK1	NNP
cord-261532-q923xxn2	55	21	)	)	-RRB-
cord-261532-q923xxn2	56	1	and/or	and/or	CC
cord-261532-q923xxn2	56	2	inducible	inducible	JJ
cord-261532-q923xxn2	56	3	IKK	IKK	NNP
cord-261532-q923xxn2	57	1	(	(	-LRB-
cord-261532-q923xxn2	57	2	IKK	IKK	NNP
cord-261532-q923xxn2	57	3	-	-	HYPH
cord-261532-q923xxn2	57	4	i)/IKK	i)/IKK	NNP
cord-261532-q923xxn2	57	5	-	-	HYPH
cord-261532-q923xxn2	57	6	ε	ε	NNP
cord-261532-q923xxn2	57	7	.	.	.
cord-261532-q923xxn2	58	1	Then	then	RB
cord-261532-q923xxn2	58	2	,	,	,
cord-261532-q923xxn2	58	3	phosphorylated	phosphorylate	VBD
cord-261532-q923xxn2	58	4	TBK1	TBK1	NNP
cord-261532-q923xxn2	58	5	or	or	CC
cord-261532-q923xxn2	58	6	IKK	IKK	NNP
cord-261532-q923xxn2	58	7	-	-	HYPH
cord-261532-q923xxn2	58	8	i	i	PRP
cord-261532-q923xxn2	58	9	activates	activate	VBZ
cord-261532-q923xxn2	58	10	IRF3	IRF3	NNP
cord-261532-q923xxn2	58	11	and	and	CC
cord-261532-q923xxn2	58	12	IRF7	IRF7	NNP
cord-261532-q923xxn2	58	13	.	.	.
cord-261532-q923xxn2	59	1	The	the	DT
cord-261532-q923xxn2	59	2	dimerization	dimerization	NN
cord-261532-q923xxn2	59	3	and	and	CC
cord-261532-q923xxn2	59	4	nuclear	nuclear	JJ
cord-261532-q923xxn2	59	5	translocation	translocation	NN
cord-261532-q923xxn2	59	6	of	of	IN
cord-261532-q923xxn2	59	7	IRF3	IRF3	NNP
cord-261532-q923xxn2	59	8	and	and	CC
cord-261532-q923xxn2	59	9	IRF7	IRF7	NNP
cord-261532-q923xxn2	59	10	lead	lead	NN
cord-261532-q923xxn2	59	11	to	to	IN
cord-261532-q923xxn2	59	12	the	the	DT
cord-261532-q923xxn2	59	13	induction	induction	NN
cord-261532-q923xxn2	59	14	of	of	IN
cord-261532-q923xxn2	59	15	type	type	NN
cord-261532-q923xxn2	59	16	I	-PRON-	PRP
cord-261532-q923xxn2	59	17	interferons	interferon	NNS
cord-261532-q923xxn2	59	18	and	and	CC
cord-261532-q923xxn2	59	19	IFN	IFN	NNP
cord-261532-q923xxn2	59	20	-	-	HYPH
cord-261532-q923xxn2	59	21	stimulated	stimulate	VBN
cord-261532-q923xxn2	59	22	genes	gene	NNS
cord-261532-q923xxn2	59	23	(	(	-LRB-
cord-261532-q923xxn2	59	24	ISGs	ISGs	NNP
cord-261532-q923xxn2	59	25	)	)	-RRB-
cord-261532-q923xxn2	59	26	.	.	.
cord-261532-q923xxn2	60	1	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	60	2	activates	activate	VBZ
cord-261532-q923xxn2	60	3	NF	NF	NNP
cord-261532-q923xxn2	60	4	-	-	HYPH
cord-261532-q923xxn2	60	5	κB	κB	NNP
cord-261532-q923xxn2	60	6	through	through	IN
cord-261532-q923xxn2	60	7	multiple	multiple	JJ
cord-261532-q923xxn2	60	8	ways	way	NNS
cord-261532-q923xxn2	60	9	in	in	IN
cord-261532-q923xxn2	60	10	complex	complex	NN
cord-261532-q923xxn2	60	11	with	with	IN
cord-261532-q923xxn2	60	12	RIP1	RIP1	NNP
cord-261532-q923xxn2	60	13	,	,	,
cord-261532-q923xxn2	60	14	TNFR	TNFR	NNP
cord-261532-q923xxn2	60	15	-	-	HYPH
cord-261532-q923xxn2	60	16	associated	associate	VBN
cord-261532-q923xxn2	60	17	death	death	NN
cord-261532-q923xxn2	60	18	domain	domain	NN
cord-261532-q923xxn2	60	19	protein	protein	NN
cord-261532-q923xxn2	60	20	(	(	-LRB-
cord-261532-q923xxn2	60	21	TRADD	TRADD	NNP
cord-261532-q923xxn2	60	22	)	)	-RRB-
cord-261532-q923xxn2	60	23	and	and	CC
cord-261532-q923xxn2	60	24	Fas	Fas	NNP
cord-261532-q923xxn2	60	25	-	-	HYPH
cord-261532-q923xxn2	60	26	associated	associate	VBN
cord-261532-q923xxn2	60	27	death	death	NN
cord-261532-q923xxn2	60	28	domain	domain	NN
cord-261532-q923xxn2	60	29	protein	protein	NN
cord-261532-q923xxn2	60	30	(	(	-LRB-
cord-261532-q923xxn2	60	31	FADD	FADD	NNP
cord-261532-q923xxn2	60	32	)	)	-RRB-
cord-261532-q923xxn2	60	33	.	.	.
cord-261532-q923xxn2	61	1	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	61	2	undergoes	undergo	VBZ
cord-261532-q923xxn2	61	3	K	K	NNP
cord-261532-q923xxn2	61	4	48	48	CD
cord-261532-q923xxn2	61	5	-and	-and	.
cord-261532-q923xxn2	62	1	K	K	NNP
cord-261532-q923xxn2	62	2	63	63	CD
cord-261532-q923xxn2	63	1	-linked	-linked	JJ
cord-261532-q923xxn2	63	2	ubiquitination	ubiquitination	NN
cord-261532-q923xxn2	63	3	in	in	IN
cord-261532-q923xxn2	63	4	either	either	CC
cord-261532-q923xxn2	63	5	MyD88-dependent	MyD88-dependent	NNP
cord-261532-q923xxn2	63	6	or	or	CC
cord-261532-q923xxn2	63	7	TRIF	TRIF	NNP
cord-261532-q923xxn2	63	8	-	-	HYPH
cord-261532-q923xxn2	63	9	dependent	dependent	JJ
cord-261532-q923xxn2	63	10	signaling	signal	VBG
cord-261532-q923xxn2	63	11	pathway	pathway	NN
cord-261532-q923xxn2	63	12	,	,	,
cord-261532-q923xxn2	63	13	indicating	indicate	VBG
cord-261532-q923xxn2	63	14	its	-PRON-	PRP$
cord-261532-q923xxn2	63	15	critical	critical	JJ
cord-261532-q923xxn2	63	16	roles	role	NNS
cord-261532-q923xxn2	63	17	in	in	IN
cord-261532-q923xxn2	63	18	both	both	DT
cord-261532-q923xxn2	63	19	pathways	pathway	NNS
cord-261532-q923xxn2	63	20	,	,	,
cord-261532-q923xxn2	63	21	fine	fine	RB
cord-261532-q923xxn2	63	22	-	-	HYPH
cord-261532-q923xxn2	63	23	tuning	tuning	VB
cord-261532-q923xxn2	63	24	the	the	DT
cord-261532-q923xxn2	63	25	production	production	NN
cord-261532-q923xxn2	63	26	of	of	IN
cord-261532-q923xxn2	63	27	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	63	28	cytokines	cytokine	NNS
cord-261532-q923xxn2	63	29	and	and	CC
cord-261532-q923xxn2	63	30	type	type	NN
cord-261532-q923xxn2	63	31	I	-PRON-	PRP
cord-261532-q923xxn2	63	32	interferons	interferon	NNS
cord-261532-q923xxn2	64	1	(	(	-LRB-
cord-261532-q923xxn2	64	2	Häcker	Häcker	NNP
cord-261532-q923xxn2	64	3	et	et	NNP
cord-261532-q923xxn2	64	4	al	al	NNP
cord-261532-q923xxn2	64	5	.	.	NNP
cord-261532-q923xxn2	64	6	,	,	,
cord-261532-q923xxn2	64	7	2006	2006	CD
cord-261532-q923xxn2	64	8	;	;	.
cord-261532-q923xxn2	65	1	Tseng	Tseng	NNP
cord-261532-q923xxn2	65	2	et	et	NNP
cord-261532-q923xxn2	65	3	al	al	NNP
cord-261532-q923xxn2	65	4	.	.	NNP
cord-261532-q923xxn2	65	5	,	,	,
cord-261532-q923xxn2	65	6	2010	2010	CD
cord-261532-q923xxn2	65	7	)	)	-RRB-
cord-261532-q923xxn2	65	8	.	.	.
cord-261532-q923xxn2	66	1	Signaling	signal	VBG
cord-261532-q923xxn2	66	2	specificity	specificity	NN
cord-261532-q923xxn2	66	3	of	of	IN
cord-261532-q923xxn2	66	4	individual	individual	JJ
cord-261532-q923xxn2	66	5	TLR	TLR	NNP
cord-261532-q923xxn2	66	6	can	can	MD
cord-261532-q923xxn2	66	7	be	be	VB
cord-261532-q923xxn2	66	8	imparted	impart	VBN
cord-261532-q923xxn2	66	9	to	to	IN
cord-261532-q923xxn2	66	10	downstream	downstream	VB
cord-261532-q923xxn2	66	11	signaling	signal	VBG
cord-261532-q923xxn2	66	12	molecules	molecule	NNS
cord-261532-q923xxn2	66	13	via	via	IN
cord-261532-q923xxn2	66	14	the	the	DT
cord-261532-q923xxn2	66	15	interaction	interaction	NN
cord-261532-q923xxn2	66	16	of	of	IN
cord-261532-q923xxn2	66	17	its	-PRON-	PRP$
cord-261532-q923xxn2	66	18	TIR	TIR	NNP
cord-261532-q923xxn2	66	19	domain	domain	NN
cord-261532-q923xxn2	66	20	with	with	IN
cord-261532-q923xxn2	66	21	MyD88	MyD88	NNS
cord-261532-q923xxn2	66	22	,	,	,
cord-261532-q923xxn2	66	23	TRIF	TRIF	NNP
cord-261532-q923xxn2	66	24	,	,	,
cord-261532-q923xxn2	66	25	TRAM	tram	NN
cord-261532-q923xxn2	66	26	or	or	CC
cord-261532-q923xxn2	66	27	TIRAP	TIRAP	NNP
cord-261532-q923xxn2	66	28	.	.	.
cord-261532-q923xxn2	67	1	TLR	TLR	NNP
cord-261532-q923xxn2	67	2	stimulation	stimulation	NN
cord-261532-q923xxn2	67	3	can	can	MD
cord-261532-q923xxn2	67	4	induce	induce	VB
cord-261532-q923xxn2	67	5	the	the	DT
cord-261532-q923xxn2	67	6	production	production	NN
cord-261532-q923xxn2	67	7	of	of	IN
cord-261532-q923xxn2	67	8	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	67	9	cytokines	cytokine	NNS
cord-261532-q923xxn2	67	10	,	,	,
cord-261532-q923xxn2	67	11	co	co	JJ
cord-261532-q923xxn2	67	12	-	-	JJ
cord-261532-q923xxn2	67	13	stimulatory	stimulatory	JJ
cord-261532-q923xxn2	67	14	molecules	molecule	NNS
cord-261532-q923xxn2	67	15	,	,	,
cord-261532-q923xxn2	67	16	type	type	NN
cord-261532-q923xxn2	67	17	І	і	CD
cord-261532-q923xxn2	67	18	interferons	interferon	NNS
cord-261532-q923xxn2	67	19	(	(	-LRB-
cord-261532-q923xxn2	67	20	IFN	IFN	NNP
cord-261532-q923xxn2	67	21	-	-	HYPH
cord-261532-q923xxn2	67	22	α	α	NNP
cord-261532-q923xxn2	67	23	/	/	SYM
cord-261532-q923xxn2	67	24	β	β	NN
cord-261532-q923xxn2	67	25	)	)	-RRB-
cord-261532-q923xxn2	67	26	,	,	,
cord-261532-q923xxn2	67	27	type	type	NN
cord-261532-q923xxn2	67	28	II	II	NNP
cord-261532-q923xxn2	67	29	interferon	interferon	NN
cord-261532-q923xxn2	67	30	(	(	-LRB-
cord-261532-q923xxn2	67	31	IFN	IFN	NNP
cord-261532-q923xxn2	67	32	-	-	HYPH
cord-261532-q923xxn2	67	33	γ	γ	NNP
cord-261532-q923xxn2	67	34	)	)	-RRB-
cord-261532-q923xxn2	67	35	and	and	CC
cord-261532-q923xxn2	67	36	chemokines	chemokine	NNS
cord-261532-q923xxn2	67	37	.	.	.
cord-261532-q923xxn2	68	1	All	all	DT
cord-261532-q923xxn2	68	2	TLRs	tlr	NNS
cord-261532-q923xxn2	68	3	except	except	IN
cord-261532-q923xxn2	68	4	TLR3	TLR3	NNP
cord-261532-q923xxn2	68	5	recruit	recruit	NN
cord-261532-q923xxn2	68	6	MyD88	MyD88	NNS
cord-261532-q923xxn2	68	7	to	to	TO
cord-261532-q923xxn2	68	8	elicit	elicit	VB
cord-261532-q923xxn2	68	9	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	68	10	expression	expression	NN
cord-261532-q923xxn2	68	11	.	.	.
cord-261532-q923xxn2	69	1	TLR2	TLR2	NNP
cord-261532-q923xxn2	69	2	and	and	CC
cord-261532-q923xxn2	69	3	TLR4	TLR4	NNP
cord-261532-q923xxn2	69	4	recruit	recruit	VBP
cord-261532-q923xxn2	69	5	TIRAP	TIRAP	NNP
cord-261532-q923xxn2	69	6	and	and	CC
cord-261532-q923xxn2	69	7	MyD88	MyD88	NNS
cord-261532-q923xxn2	69	8	to	to	TO
cord-261532-q923xxn2	69	9	activate	activate	VB
cord-261532-q923xxn2	69	10	NF	NF	NNP
cord-261532-q923xxn2	69	11	-	-	HYPH
cord-261532-q923xxn2	69	12	κB	κB	NNP
cord-261532-q923xxn2	69	13	and	and	CC
cord-261532-q923xxn2	69	14	MAPKs	mapk	NNS
cord-261532-q923xxn2	69	15	for	for	IN
cord-261532-q923xxn2	69	16	the	the	DT
cord-261532-q923xxn2	69	17	production	production	NN
cord-261532-q923xxn2	69	18	of	of	IN
cord-261532-q923xxn2	69	19	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	69	20	cytokines	cytokine	NNS
cord-261532-q923xxn2	69	21	,	,	,
cord-261532-q923xxn2	69	22	and	and	CC
cord-261532-q923xxn2	69	23	TLR5	TLR5	NNP
cord-261532-q923xxn2	69	24	directly	directly	RB
cord-261532-q923xxn2	69	25	interacts	interact	VBZ
cord-261532-q923xxn2	69	26	with	with	IN
cord-261532-q923xxn2	69	27	MyD88	MyD88	NNS
cord-261532-q923xxn2	69	28	to	to	TO
cord-261532-q923xxn2	69	29	trigger	trigger	VB
cord-261532-q923xxn2	69	30	NF	nf	NN
cord-261532-q923xxn2	69	31	-	-	HYPH
cord-261532-q923xxn2	69	32	κB	κB	NNP
cord-261532-q923xxn2	69	33	and	and	CC
cord-261532-q923xxn2	69	34	MAPK	MAPK	NNP
cord-261532-q923xxn2	69	35	signaling	signal	VBG
cord-261532-q923xxn2	69	36	pathways	pathway	NNS
cord-261532-q923xxn2	69	37	.	.	.
cord-261532-q923xxn2	70	1	In	in	IN
cord-261532-q923xxn2	70	2	addition	addition	NN
cord-261532-q923xxn2	70	3	,	,	,
cord-261532-q923xxn2	70	4	TLR4	TLR4	NNP
cord-261532-q923xxn2	70	5	(	(	-LRB-
cord-261532-q923xxn2	70	6	utilizes	utilize	VBZ
cord-261532-q923xxn2	70	7	TRAM	tram	NN
cord-261532-q923xxn2	70	8	)	)	-RRB-
cord-261532-q923xxn2	70	9	and	and	CC
cord-261532-q923xxn2	70	10	TLR3	TLR3	NNP
cord-261532-q923xxn2	70	11	activate	activate	VBP
cord-261532-q923xxn2	70	12	IRF3	IRF3	NNP
cord-261532-q923xxn2	70	13	via	via	IN
cord-261532-q923xxn2	70	14	TRIF	TRIF	NNP
cord-261532-q923xxn2	70	15	for	for	IN
cord-261532-q923xxn2	70	16	the	the	DT
cord-261532-q923xxn2	70	17	induction	induction	NN
cord-261532-q923xxn2	70	18	of	of	IN
cord-261532-q923xxn2	70	19	type	type	NN
cord-261532-q923xxn2	70	20	І	і	CD
cord-261532-q923xxn2	70	21	interferons	interferon	NNS
cord-261532-q923xxn2	70	22	.	.	.
cord-261532-q923xxn2	71	1	In	in	IN
cord-261532-q923xxn2	71	2	plasmacytoid	plasmacytoid	NNP
cord-261532-q923xxn2	71	3	dendritic	dendritic	JJ
cord-261532-q923xxn2	71	4	cells	cell	NNS
cord-261532-q923xxn2	71	5	(	(	-LRB-
cord-261532-q923xxn2	71	6	pDCs	pDCs	NNP
cord-261532-q923xxn2	71	7	)	)	-RRB-
cord-261532-q923xxn2	71	8	,	,	,
cord-261532-q923xxn2	71	9	the	the	DT
cord-261532-q923xxn2	71	10	TLR7	TLR7	NNP
cord-261532-q923xxn2	71	11	/	/	SYM
cord-261532-q923xxn2	71	12	TLR9-MyD88	TLR9-MyD88	NNP
cord-261532-q923xxn2	71	13	axis	axis	NN
cord-261532-q923xxn2	71	14	elicits	elicit	VBZ
cord-261532-q923xxn2	71	15	the	the	DT
cord-261532-q923xxn2	71	16	expression	expression	NN
cord-261532-q923xxn2	71	17	of	of	IN
cord-261532-q923xxn2	71	18	IFN	IFN	NNP
cord-261532-q923xxn2	71	19	-	-	HYPH
cord-261532-q923xxn2	71	20	α	α	NNP
cord-261532-q923xxn2	71	21	and	and	CC
cord-261532-q923xxn2	71	22	IFN	IFN	NNP
cord-261532-q923xxn2	71	23	-	-	HYPH
cord-261532-q923xxn2	71	24	related	relate	VBN
cord-261532-q923xxn2	71	25	genes	gene	NNS
cord-261532-q923xxn2	71	26	.	.	.
cord-261532-q923xxn2	72	1	MyD88-dependent	MyD88-dependent	NNP
cord-261532-q923xxn2	72	2	signaling	signal	VBG
cord-261532-q923xxn2	72	3	pathway	pathway	NN
cord-261532-q923xxn2	72	4	:	:	:
cord-261532-q923xxn2	73	1	Upon	upon	IN
cord-261532-q923xxn2	73	2	specific	specific	JJ
cord-261532-q923xxn2	73	3	ligand	ligand	NN
cord-261532-q923xxn2	73	4	recognition	recognition	NN
cord-261532-q923xxn2	73	5	,	,	,
cord-261532-q923xxn2	73	6	the	the	DT
cord-261532-q923xxn2	73	7	TIR	TIR	NNP
cord-261532-q923xxn2	73	8	of	of	IN
cord-261532-q923xxn2	73	9	TLR2	TLR2	NNP
cord-261532-q923xxn2	73	10	and	and	CC
cord-261532-q923xxn2	73	11	TLR4	TLR4	NNP
cord-261532-q923xxn2	73	12	interacts	interact	VBZ
cord-261532-q923xxn2	73	13	with	with	IN
cord-261532-q923xxn2	73	14	TIRAP	TIRAP	NNP
cord-261532-q923xxn2	73	15	and	and	CC
cord-261532-q923xxn2	73	16	MyD88	MyD88	NNS
cord-261532-q923xxn2	73	17	.	.	.
cord-261532-q923xxn2	74	1	Sequentially	sequentially	RB
cord-261532-q923xxn2	74	2	,	,	,
cord-261532-q923xxn2	74	3	MyD88	MyD88	NNP
cord-261532-q923xxn2	74	4	re	re	NN
cord-261532-q923xxn2	74	5	-	-	NN
cord-261532-q923xxn2	74	6	cruits	cruit	NNS
cord-261532-q923xxn2	75	1	and	and	CC
cord-261532-q923xxn2	75	2	activates	activate	VBZ
cord-261532-q923xxn2	75	3	IRAK4	IRAK4	NNP
cord-261532-q923xxn2	75	4	,	,	,
cord-261532-q923xxn2	75	5	which	which	WDT
cord-261532-q923xxn2	75	6	in	in	IN
cord-261532-q923xxn2	75	7	turn	turn	NN
cord-261532-q923xxn2	75	8	activates	activate	VBZ
cord-261532-q923xxn2	75	9	another	another	DT
cord-261532-q923xxn2	75	10	IRAK	IRAK	NNP
cord-261532-q923xxn2	75	11	family	family	NN
cord-261532-q923xxn2	75	12	member	member	NN
cord-261532-q923xxn2	75	13	-	-	HYPH
cord-261532-q923xxn2	75	14	IRAK1	irak1	JJ
cord-261532-q923xxn2	75	15	.	.	.
cord-261532-q923xxn2	76	1	The	the	DT
cord-261532-q923xxn2	76	2	downstream	downstream	JJ
cord-261532-q923xxn2	76	3	activation	activation	NN
cord-261532-q923xxn2	76	4	of	of	IN
cord-261532-q923xxn2	76	5	TRAF6	traf6	NN
cord-261532-q923xxn2	76	6	by	by	IN
cord-261532-q923xxn2	76	7	IRAK4/1	IRAK4/1	NNP
cord-261532-q923xxn2	76	8	leads	lead	VBZ
cord-261532-q923xxn2	76	9	to	to	IN
cord-261532-q923xxn2	76	10	the	the	DT
cord-261532-q923xxn2	76	11	activation	activation	NN
cord-261532-q923xxn2	76	12	of	of	IN
cord-261532-q923xxn2	76	13	TAK1	TAK1	NNP
cord-261532-q923xxn2	76	14	and	and	CC
cord-261532-q923xxn2	76	15	TAB	TAB	NNP
cord-261532-q923xxn2	76	16	complex	complex	NN
cord-261532-q923xxn2	76	17	,	,	,
cord-261532-q923xxn2	76	18	which	which	WDT
cord-261532-q923xxn2	76	19	can	can	MD
cord-261532-q923xxn2	76	20	stimulate	stimulate	VB
cord-261532-q923xxn2	76	21	both	both	DT
cord-261532-q923xxn2	76	22	NF	nf	NN
cord-261532-q923xxn2	76	23	-	-	HYPH
cord-261532-q923xxn2	76	24	κB	κB	NNP
cord-261532-q923xxn2	76	25	and	and	CC
cord-261532-q923xxn2	76	26	MAPK	MAPK	NNP
cord-261532-q923xxn2	76	27	signaling	signal	VBG
cord-261532-q923xxn2	76	28	pathways	pathway	NNS
cord-261532-q923xxn2	76	29	.	.	.
cord-261532-q923xxn2	77	1	Activated	activate	VBN
cord-261532-q923xxn2	77	2	IKK	IKK	NNP
cord-261532-q923xxn2	77	3	complex	complex	NN
cord-261532-q923xxn2	77	4	(	(	-LRB-
cord-261532-q923xxn2	77	5	consisting	consist	VBG
cord-261532-q923xxn2	77	6	of	of	IN
cord-261532-q923xxn2	77	7	IKK	IKK	NNP
cord-261532-q923xxn2	77	8	-	-	HYPH
cord-261532-q923xxn2	77	9	α	α	NNP
cord-261532-q923xxn2	77	10	,	,	,
cord-261532-q923xxn2	77	11	IKK	IKK	NNP
cord-261532-q923xxn2	77	12	-	-	HYPH
cord-261532-q923xxn2	77	13	β	β	NNP
cord-261532-q923xxn2	77	14	and	and	CC
cord-261532-q923xxn2	77	15	NEMO	NEMO	NNP
cord-261532-q923xxn2	77	16	)	)	-RRB-
cord-261532-q923xxn2	77	17	causes	cause	VBZ
cord-261532-q923xxn2	77	18	the	the	DT
cord-261532-q923xxn2	77	19	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	77	20	and	and	CC
cord-261532-q923xxn2	77	21	degradation	degradation	NN
cord-261532-q923xxn2	77	22	of	of	IN
cord-261532-q923xxn2	77	23	IκBα	IκBα	NNP
cord-261532-q923xxn2	77	24	,	,	,
cord-261532-q923xxn2	77	25	releasing	release	VBG
cord-261532-q923xxn2	77	26	NF	nf	NN
cord-261532-q923xxn2	77	27	-	-	HYPH
cord-261532-q923xxn2	77	28	κB	κB	NNP
cord-261532-q923xxn2	77	29	for	for	IN
cord-261532-q923xxn2	77	30	its	-PRON-	PRP$
cord-261532-q923xxn2	77	31	nuclear	nuclear	JJ
cord-261532-q923xxn2	77	32	translocation	translocation	NN
cord-261532-q923xxn2	77	33	and	and	CC
cord-261532-q923xxn2	77	34	transcription	transcription	NN
cord-261532-q923xxn2	77	35	initiation	initiation	NN
cord-261532-q923xxn2	77	36	.	.	.
cord-261532-q923xxn2	78	1	In	in	IN
cord-261532-q923xxn2	78	2	pDCs	pDCs	NNP
cord-261532-q923xxn2	78	3	,	,	,
cord-261532-q923xxn2	78	4	MyD88	MyD88	NNP
cord-261532-q923xxn2	78	5	recruits	recruit	VBZ
cord-261532-q923xxn2	78	6	IRAK4/1	IRAK4/1	NNP
cord-261532-q923xxn2	78	7	to	to	TO
cord-261532-q923xxn2	78	8	activate	activate	VB
cord-261532-q923xxn2	78	9	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	79	1	and	and	CC
cord-261532-q923xxn2	79	2	ultimately	ultimately	RB
cord-261532-q923xxn2	79	3	the	the	DT
cord-261532-q923xxn2	79	4	transcriptional	transcriptional	JJ
cord-261532-q923xxn2	79	5	factor	factor	NN
cord-261532-q923xxn2	80	1	IRF7	IRF7	NNP
cord-261532-q923xxn2	80	2	.	.	.
cord-261532-q923xxn2	81	1	TRIF	trif	NN
cord-261532-q923xxn2	81	2	-	-	HYPH
cord-261532-q923xxn2	81	3	dependent	dependent	JJ
cord-261532-q923xxn2	81	4	signaling	signal	VBG
cord-261532-q923xxn2	81	5	pathway	pathway	NN
cord-261532-q923xxn2	81	6	:	:	:
cord-261532-q923xxn2	82	1	Upon	upon	IN
cord-261532-q923xxn2	82	2	ligand	ligand	NN
cord-261532-q923xxn2	82	3	binding	binding	NN
cord-261532-q923xxn2	82	4	,	,	,
cord-261532-q923xxn2	82	5	TLR3	TLR3	NNP
cord-261532-q923xxn2	82	6	directly	directly	RB
cord-261532-q923xxn2	82	7	recruits	recruit	VBZ
cord-261532-q923xxn2	82	8	TRIF	TRIF	NNP
cord-261532-q923xxn2	82	9	via	via	IN
cord-261532-q923xxn2	82	10	its	-PRON-	PRP$
cord-261532-q923xxn2	82	11	TIR	TIR	NNP
cord-261532-q923xxn2	82	12	domain	domain	NN
cord-261532-q923xxn2	82	13	while	while	IN
cord-261532-q923xxn2	82	14	TLR4	TLR4	NNP
cord-261532-q923xxn2	82	15	utilizes	utilize	VBZ
cord-261532-q923xxn2	82	16	TRAM	tram	NN
cord-261532-q923xxn2	82	17	to	to	TO
cord-261532-q923xxn2	82	18	interact	interact	VB
cord-261532-q923xxn2	82	19	with	with	IN
cord-261532-q923xxn2	82	20	TRIF	TRIF	NNP
cord-261532-q923xxn2	82	21	.	.	.
cord-261532-q923xxn2	83	1	TRIF	TRIF	NNP
cord-261532-q923xxn2	83	2	-	-	HYPH
cord-261532-q923xxn2	83	3	recruited	recruit	VBN
cord-261532-q923xxn2	83	4	TRAF3	traf3	NN
cord-261532-q923xxn2	83	5	mediates	mediate	VBZ
cord-261532-q923xxn2	83	6	the	the	DT
cord-261532-q923xxn2	83	7	activation	activation	NN
cord-261532-q923xxn2	83	8	of	of	IN
cord-261532-q923xxn2	83	9	TBK1	TBK1	NNP
cord-261532-q923xxn2	83	10	and/or	and/or	CC
cord-261532-q923xxn2	83	11	IKK	IKK	NNP
cord-261532-q923xxn2	83	12	-	-	HYPH
cord-261532-q923xxn2	83	13	i	i	NNP
cord-261532-q923xxn2	83	14	,	,	,
cord-261532-q923xxn2	83	15	which	which	WDT
cord-261532-q923xxn2	83	16	phosphorylate	phosphorylate	VBP
cord-261532-q923xxn2	83	17	IRF3	IRF3	NNP
cord-261532-q923xxn2	83	18	.	.	.
cord-261532-q923xxn2	84	1	IRF3	IRF3	NNP
cord-261532-q923xxn2	84	2	then	then	RB
cord-261532-q923xxn2	84	3	dimerizes	dimerize	VBZ
cord-261532-q923xxn2	84	4	and	and	CC
cord-261532-q923xxn2	84	5	translocates	translocates	NNP
cord-261532-q923xxn2	84	6	to	to	IN
cord-261532-q923xxn2	84	7	the	the	DT
cord-261532-q923xxn2	84	8	nucleus	nucleus	NN
cord-261532-q923xxn2	84	9	for	for	IN
cord-261532-q923xxn2	84	10	the	the	DT
cord-261532-q923xxn2	84	11	induction	induction	NN
cord-261532-q923xxn2	84	12	of	of	IN
cord-261532-q923xxn2	84	13	cytokines	cytokine	NNS
cord-261532-q923xxn2	84	14	such	such	JJ
cord-261532-q923xxn2	84	15	as	as	IN
cord-261532-q923xxn2	84	16	type	type	NN
cord-261532-q923xxn2	84	17	І	і	CD
cord-261532-q923xxn2	84	18	interferons	interferon	NNS
cord-261532-q923xxn2	84	19	and	and	CC
cord-261532-q923xxn2	84	20	IL-10	IL-10	NNP
cord-261532-q923xxn2	84	21	.	.	.
cord-261532-q923xxn2	85	1	Meanwhile	meanwhile	RB
cord-261532-q923xxn2	85	2	,	,	,
cord-261532-q923xxn2	85	3	TRIF	TRIF	NNP
cord-261532-q923xxn2	85	4	also	also	RB
cord-261532-q923xxn2	85	5	recruits	recruit	VBZ
cord-261532-q923xxn2	85	6	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	85	7	and	and	CC
cord-261532-q923xxn2	85	8	RIP1	RIP1	NNP
cord-261532-q923xxn2	85	9	,	,	,
cord-261532-q923xxn2	85	10	which	which	WDT
cord-261532-q923xxn2	85	11	in	in	IN
cord-261532-q923xxn2	85	12	turn	turn	NN
cord-261532-q923xxn2	85	13	activate	activate	VBP
cord-261532-q923xxn2	85	14	the	the	DT
cord-261532-q923xxn2	85	15	TAK1	TAK1	NNP
cord-261532-q923xxn2	85	16	/	/	SYM
cord-261532-q923xxn2	85	17	TAB	TAB	NNP
cord-261532-q923xxn2	85	18	complex	complex	NN
cord-261532-q923xxn2	85	19	responsible	responsible	JJ
cord-261532-q923xxn2	85	20	for	for	IN
cord-261532-q923xxn2	85	21	the	the	DT
cord-261532-q923xxn2	85	22	activation	activation	NN
cord-261532-q923xxn2	85	23	of	of	IN
cord-261532-q923xxn2	85	24	NF	nf	NN
cord-261532-q923xxn2	85	25	-	-	HYPH
cord-261532-q923xxn2	85	26	κB.	κb.	JJ
cord-261532-q923xxn2	85	27	MAVS	MAVS	NNPS
cord-261532-q923xxn2	85	28	,	,	,
cord-261532-q923xxn2	85	29	also	also	RB
cord-261532-q923xxn2	85	30	named	name	VBN
cord-261532-q923xxn2	85	31	interferon	interferon	NN
cord-261532-q923xxn2	85	32	promoter	promoter	NN
cord-261532-q923xxn2	85	33	stimulator-1	stimulator-1	NNP
cord-261532-q923xxn2	86	1	(	(	-LRB-
cord-261532-q923xxn2	86	2	IPS-1)/Caspase	IPS-1)/Caspase	NNP
cord-261532-q923xxn2	86	3	recruitment	recruitment	NN
cord-261532-q923xxn2	86	4	domain	domain	NN
cord-261532-q923xxn2	86	5	(	(	-LRB-
cord-261532-q923xxn2	86	6	CARD	card	NN
cord-261532-q923xxn2	86	7	)	)	-RRB-
cord-261532-q923xxn2	86	8	adaptor	adaptor	NN
cord-261532-q923xxn2	86	9	inducing	induce	VBG
cord-261532-q923xxn2	86	10	IFN	IFN	NNP
cord-261532-q923xxn2	86	11	-	-	HYPH
cord-261532-q923xxn2	86	12	β	β	NNP
cord-261532-q923xxn2	86	13	(	(	-LRB-
cord-261532-q923xxn2	86	14	Cardif	Cardif	NNP
cord-261532-q923xxn2	86	15	)	)	-RRB-
cord-261532-q923xxn2	86	16	/virus	/virus	.
cord-261532-q923xxn2	87	1	-induced	-induced	JJ
cord-261532-q923xxn2	87	2	signaling	signal	VBG
cord-261532-q923xxn2	87	3	adaptor	adaptor	NN
cord-261532-q923xxn2	87	4	(	(	-LRB-
cord-261532-q923xxn2	87	5	VISA	VISA	NNP
cord-261532-q923xxn2	87	6	)	)	-RRB-
cord-261532-q923xxn2	88	1	(	(	-LRB-
cord-261532-q923xxn2	88	2	Meylan	Meylan	NNP
cord-261532-q923xxn2	88	3	et	et	NNP
cord-261532-q923xxn2	88	4	al	al	NNP
cord-261532-q923xxn2	88	5	.	.	NNP
cord-261532-q923xxn2	88	6	,	,	,
cord-261532-q923xxn2	88	7	2005	2005	CD
cord-261532-q923xxn2	88	8	;	;	:
cord-261532-q923xxn2	89	1	Kawai	Kawai	NNP
cord-261532-q923xxn2	89	2	et	et	NNP
cord-261532-q923xxn2	89	3	al	al	NNP
cord-261532-q923xxn2	89	4	.	.	.
cord-261532-q923xxn2	90	1	,	,	,
cord-261532-q923xxn2	90	2	2005	2005	CD
cord-261532-q923xxn2	90	3	;	;	:
cord-261532-q923xxn2	90	4	Seth	Seth	NNP
cord-261532-q923xxn2	90	5	et	et	NNP
cord-261532-q923xxn2	90	6	al	al	NNP
cord-261532-q923xxn2	90	7	.	.	NNP
cord-261532-q923xxn2	90	8	,	,	,
cord-261532-q923xxn2	90	9	2005	2005	CD
cord-261532-q923xxn2	91	1	;	;	:
cord-261532-q923xxn2	91	2	Xu	Xu	NNP
cord-261532-q923xxn2	91	3	et	et	NNP
cord-261532-q923xxn2	91	4	al	al	NNP
cord-261532-q923xxn2	91	5	.	.	NNP
cord-261532-q923xxn2	91	6	,	,	,
cord-261532-q923xxn2	91	7	2005	2005	CD
cord-261532-q923xxn2	91	8	)	)	-RRB-
cord-261532-q923xxn2	91	9	,	,	,
cord-261532-q923xxn2	91	10	is	be	VBZ
cord-261532-q923xxn2	91	11	a	a	DT
cord-261532-q923xxn2	91	12	mitochondrial	mitochondrial	JJ
cord-261532-q923xxn2	91	13	outer	outer	JJ
cord-261532-q923xxn2	91	14	membrane	membrane	NN
cord-261532-q923xxn2	91	15	protein	protein	NN
cord-261532-q923xxn2	91	16	participating	participate	VBG
cord-261532-q923xxn2	91	17	in	in	IN
cord-261532-q923xxn2	91	18	the	the	DT
cord-261532-q923xxn2	91	19	intracellular	intracellular	JJ
cord-261532-q923xxn2	91	20	RLR	RLR	NNP
cord-261532-q923xxn2	91	21	pathways	pathway	NNS
cord-261532-q923xxn2	91	22	(	(	-LRB-
cord-261532-q923xxn2	91	23	Thompson	Thompson	NNP
cord-261532-q923xxn2	91	24	and	and	CC
cord-261532-q923xxn2	91	25	Locarnini	Locarnini	NNP
cord-261532-q923xxn2	91	26	,	,	,
cord-261532-q923xxn2	91	27	2007	2007	CD
cord-261532-q923xxn2	91	28	)	)	-RRB-
cord-261532-q923xxn2	91	29	.	.	.
cord-261532-q923xxn2	92	1	It	-PRON-	PRP
cord-261532-q923xxn2	92	2	is	be	VBZ
cord-261532-q923xxn2	92	3	also	also	RB
cord-261532-q923xxn2	92	4	implicated	implicate	VBN
cord-261532-q923xxn2	92	5	to	to	TO
cord-261532-q923xxn2	92	6	locate	locate	VB
cord-261532-q923xxn2	92	7	to	to	IN
cord-261532-q923xxn2	92	8	peroxisomes	peroxisome	NNS
cord-261532-q923xxn2	92	9	,	,	,
cord-261532-q923xxn2	92	10	and	and	CC
cord-261532-q923xxn2	92	11	both	both	DT
cord-261532-q923xxn2	92	12	localizations	localization	NNS
cord-261532-q923xxn2	92	13	seem	seem	VBP
cord-261532-q923xxn2	92	14	necessary	necessary	JJ
cord-261532-q923xxn2	92	15	for	for	IN
cord-261532-q923xxn2	92	16	a	a	DT
cord-261532-q923xxn2	92	17	maximal	maximal	JJ
cord-261532-q923xxn2	92	18	antiviral	antiviral	JJ
cord-261532-q923xxn2	92	19	response	response	NN
cord-261532-q923xxn2	92	20	.	.	.
cord-261532-q923xxn2	93	1	Peroxisomal	Peroxisomal	NNP
cord-261532-q923xxn2	93	2	MAVS	MAVS	NNP
cord-261532-q923xxn2	93	3	activates	activate	VBZ
cord-261532-q923xxn2	93	4	IRF1	IRF1	NNP
cord-261532-q923xxn2	93	5	to	to	TO
cord-261532-q923xxn2	93	6	induce	induce	VB
cord-261532-q923xxn2	93	7	the	the	DT
cord-261532-q923xxn2	93	8	expression	expression	NN
cord-261532-q923xxn2	93	9	of	of	IN
cord-261532-q923xxn2	93	10	ISGs	isg	NNS
cord-261532-q923xxn2	93	11	as	as	IN
cord-261532-q923xxn2	93	12	the	the	DT
cord-261532-q923xxn2	93	13	primary	primary	JJ
cord-261532-q923xxn2	93	14	antiviral	antiviral	JJ
cord-261532-q923xxn2	93	15	responses	response	NNS
cord-261532-q923xxn2	93	16	,	,	,
cord-261532-q923xxn2	93	17	while	while	IN
cord-261532-q923xxn2	93	18	mitochondrial	mitochondrial	NN
cord-261532-q923xxn2	93	19	MAVS	MAVS	NNP
cord-261532-q923xxn2	93	20	works	work	VBZ
cord-261532-q923xxn2	93	21	in	in	IN
cord-261532-q923xxn2	93	22	a	a	DT
cord-261532-q923xxn2	93	23	delayed	delay	VBN
cord-261532-q923xxn2	93	24	stage	stage	NN
cord-261532-q923xxn2	93	25	for	for	IN
cord-261532-q923xxn2	93	26	the	the	DT
cord-261532-q923xxn2	93	27	vast	vast	JJ
cord-261532-q923xxn2	93	28	production	production	NN
cord-261532-q923xxn2	93	29	of	of	IN
cord-261532-q923xxn2	93	30	ISGs	isg	NNS
cord-261532-q923xxn2	93	31	and	and	CC
cord-261532-q923xxn2	93	32	type	type	NN
cord-261532-q923xxn2	93	33	I	-PRON-	PRP
cord-261532-q923xxn2	93	34	interferons	interferon	NNS
cord-261532-q923xxn2	93	35	via	via	IN
cord-261532-q923xxn2	93	36	the	the	DT
cord-261532-q923xxn2	93	37	activation	activation	NN
cord-261532-q923xxn2	93	38	of	of	IN
cord-261532-q923xxn2	93	39	IRF3	IRF3	NNP
cord-261532-q923xxn2	94	1	(	(	-LRB-
cord-261532-q923xxn2	94	2	Dixit	Dixit	NNP
cord-261532-q923xxn2	94	3	et	et	FW
cord-261532-q923xxn2	94	4	al	al	NNP
cord-261532-q923xxn2	94	5	.	.	NNP
cord-261532-q923xxn2	94	6	,	,	,
cord-261532-q923xxn2	94	7	2010	2010	CD
cord-261532-q923xxn2	94	8	)	)	-RRB-
cord-261532-q923xxn2	94	9	.	.	.
cord-261532-q923xxn2	95	1	RLRs	rlr	NNS
cord-261532-q923xxn2	95	2	belong	belong	VBP
cord-261532-q923xxn2	95	3	to	to	IN
cord-261532-q923xxn2	95	4	the	the	DT
cord-261532-q923xxn2	95	5	DExD	DExD	NNS
cord-261532-q923xxn2	95	6	/	/	SYM
cord-261532-q923xxn2	95	7	H	H	NNP
cord-261532-q923xxn2	95	8	-	-	HYPH
cord-261532-q923xxn2	95	9	box	box	NN
cord-261532-q923xxn2	95	10	protein	protein	NN
cord-261532-q923xxn2	95	11	family	family	NN
cord-261532-q923xxn2	95	12	,	,	,
cord-261532-q923xxn2	95	13	and	and	CC
cord-261532-q923xxn2	95	14	serve	serve	VB
cord-261532-q923xxn2	95	15	as	as	IN
cord-261532-q923xxn2	95	16	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	95	17	RNA	RNA	NNP
cord-261532-q923xxn2	95	18	sensors	sensor	NNS
cord-261532-q923xxn2	95	19	.	.	.
cord-261532-q923xxn2	96	1	To	to	IN
cord-261532-q923xxn2	96	2	date	date	NN
cord-261532-q923xxn2	96	3	,	,	,
cord-261532-q923xxn2	96	4	there	there	EX
cord-261532-q923xxn2	96	5	exist	exist	VBP
cord-261532-q923xxn2	96	6	three	three	CD
cord-261532-q923xxn2	96	7	members	member	NNS
cord-261532-q923xxn2	96	8	:	:	:
cord-261532-q923xxn2	96	9	RIG	rig	NN
cord-261532-q923xxn2	96	10	-	-	:
cord-261532-q923xxn2	96	11	I	i	NN
cord-261532-q923xxn2	96	12	,	,	,
cord-261532-q923xxn2	96	13	melanoma	melanoma	NN
cord-261532-q923xxn2	96	14	differentiation	differentiation	NN
cord-261532-q923xxn2	96	15	associated	associate	VBD
cord-261532-q923xxn2	96	16	factor	factor	NN
cord-261532-q923xxn2	96	17	5	5	CD
cord-261532-q923xxn2	96	18	(	(	-LRB-
cord-261532-q923xxn2	96	19	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	96	20	)	)	-RRB-
cord-261532-q923xxn2	96	21	and	and	CC
cord-261532-q923xxn2	96	22	laboratory	laboratory	NN
cord-261532-q923xxn2	96	23	of	of	IN
cord-261532-q923xxn2	96	24	genetics	genetic	NNS
cord-261532-q923xxn2	96	25	and	and	CC
cord-261532-q923xxn2	96	26	physiology	physiology	NN
cord-261532-q923xxn2	96	27	2	2	CD
cord-261532-q923xxn2	96	28	(	(	-LRB-
cord-261532-q923xxn2	96	29	LGP2	LGP2	NNP
cord-261532-q923xxn2	96	30	)	)	-RRB-
cord-261532-q923xxn2	96	31	(	(	-LRB-
cord-261532-q923xxn2	96	32	Yoneyama	Yoneyama	NNP
cord-261532-q923xxn2	96	33	and	and	CC
cord-261532-q923xxn2	96	34	Fujita	Fujita	NNP
cord-261532-q923xxn2	96	35	,	,	,
cord-261532-q923xxn2	96	36	2008	2008	CD
cord-261532-q923xxn2	96	37	)	)	-RRB-
cord-261532-q923xxn2	96	38	.	.	.
cord-261532-q923xxn2	97	1	RIG	rig	NN
cord-261532-q923xxn2	97	2	-	-	:
cord-261532-q923xxn2	97	3	I	I	NNP
cord-261532-q923xxn2	97	4	and	and	CC
cord-261532-q923xxn2	97	5	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	97	6	comprise	comprise	VBP
cord-261532-q923xxn2	97	7	of	of	IN
cord-261532-q923xxn2	97	8	two	two	CD
cord-261532-q923xxn2	97	9	N	n	CD
cord-261532-q923xxn2	97	10	-	-	HYPH
cord-261532-q923xxn2	97	11	terminal	terminal	NN
cord-261532-q923xxn2	97	12	CARD	card	NN
cord-261532-q923xxn2	97	13	domains	domain	NNS
cord-261532-q923xxn2	97	14	,	,	,
cord-261532-q923xxn2	97	15	a	a	DT
cord-261532-q923xxn2	97	16	DEAD	DEAD	NNP
cord-261532-q923xxn2	97	17	-	-	HYPH
cord-261532-q923xxn2	97	18	box	box	NN
cord-261532-q923xxn2	97	19	helicase/	helicase/	CD
cord-261532-q923xxn2	98	1	ATPase	ATPase	NNP
cord-261532-q923xxn2	98	2	domain	domain	NN
cord-261532-q923xxn2	98	3	in	in	IN
cord-261532-q923xxn2	98	4	the	the	DT
cord-261532-q923xxn2	98	5	middle	middle	NN
cord-261532-q923xxn2	98	6	and	and	CC
cord-261532-q923xxn2	98	7	a	a	DT
cord-261532-q923xxn2	98	8	C	c	NN
cord-261532-q923xxn2	98	9	-	-	HYPH
cord-261532-q923xxn2	98	10	terminal	terminal	NN
cord-261532-q923xxn2	98	11	regulatory	regulatory	JJ
cord-261532-q923xxn2	98	12	domain	domain	NN
cord-261532-q923xxn2	98	13	.	.	.
cord-261532-q923xxn2	99	1	RIG	rig	NN
cord-261532-q923xxn2	99	2	-	-	:
cord-261532-q923xxn2	99	3	I	-PRON-	PRP
cord-261532-q923xxn2	99	4	mainly	mainly	RB
cord-261532-q923xxn2	99	5	recognizes	recognize	VBZ
cord-261532-q923xxn2	99	6	paramyxovirus	paramyxovirus	JJ
cord-261532-q923xxn2	99	7	such	such	JJ
cord-261532-q923xxn2	99	8	as	as	IN
cord-261532-q923xxn2	99	9	Newcastle	Newcastle	NNP
cord-261532-q923xxn2	99	10	disease	disease	NN
cord-261532-q923xxn2	99	11	virus	virus	NN
cord-261532-q923xxn2	99	12	(	(	-LRB-
cord-261532-q923xxn2	99	13	NDV	NDV	NNP
cord-261532-q923xxn2	99	14	)	)	-RRB-
cord-261532-q923xxn2	99	15	and	and	CC
cord-261532-q923xxn2	99	16	vesicular	vesicular	JJ
cord-261532-q923xxn2	99	17	stomatitis	stomatitis	NN
cord-261532-q923xxn2	99	18	virus	virus	NN
cord-261532-q923xxn2	99	19	(	(	-LRB-
cord-261532-q923xxn2	99	20	VSV	VSV	NNP
cord-261532-q923xxn2	99	21	)	)	-RRB-
cord-261532-q923xxn2	99	22	.	.	.
cord-261532-q923xxn2	100	1	In	in	IN
cord-261532-q923xxn2	100	2	addition	addition	NN
cord-261532-q923xxn2	100	3	,	,	,
cord-261532-q923xxn2	100	4	RIG	rig	NN
cord-261532-q923xxn2	100	5	-	-	:
cord-261532-q923xxn2	100	6	I	-PRON-	PRP
cord-261532-q923xxn2	100	7	recognizes	recognize	VBZ
cord-261532-q923xxn2	100	8	Flaviviridae	Flaviviridae	NNP
cord-261532-q923xxn2	100	9	,	,	,
cord-261532-q923xxn2	100	10	such	such	JJ
cord-261532-q923xxn2	100	11	as	as	IN
cord-261532-q923xxn2	100	12	Japanese	japanese	JJ
cord-261532-q923xxn2	100	13	Encephalitis	Encephalitis	NNP
cord-261532-q923xxn2	100	14	virus	virus	NN
cord-261532-q923xxn2	100	15	(	(	-LRB-
cord-261532-q923xxn2	100	16	JEV	JEV	NNP
cord-261532-q923xxn2	100	17	)	)	-RRB-
cord-261532-q923xxn2	100	18	and	and	CC
cord-261532-q923xxn2	100	19	hepatitis	hepatitis	NNP
cord-261532-q923xxn2	100	20	C	C	NNP
cord-261532-q923xxn2	100	21	virus	virus	NN
cord-261532-q923xxn2	100	22	(	(	-LRB-
cord-261532-q923xxn2	100	23	HCV	HCV	NNP
cord-261532-q923xxn2	100	24	)	)	-RRB-
cord-261532-q923xxn2	100	25	.	.	.
cord-261532-q923xxn2	101	1	Meanwhile	meanwhile	RB
cord-261532-q923xxn2	101	2	,	,	,
cord-261532-q923xxn2	101	3	RIG	rig	NN
cord-261532-q923xxn2	101	4	-	-	:
cord-261532-q923xxn2	101	5	I	-PRON-	PRP
cord-261532-q923xxn2	101	6	only	only	RB
cord-261532-q923xxn2	101	7	senses	sense	VBZ
cord-261532-q923xxn2	101	8	relatively	relatively	RB
cord-261532-q923xxn2	101	9	short	short	JJ
cord-261532-q923xxn2	101	10	dsRNA	dsRNA	.
cord-261532-q923xxn2	102	1	(	(	-LRB-
cord-261532-q923xxn2	102	2	about	about	RB
cord-261532-q923xxn2	102	3	1	1	CD
cord-261532-q923xxn2	102	4	kb	kb	NNP
cord-261532-q923xxn2	102	5	)	)	-RRB-
cord-261532-q923xxn2	102	6	,	,	,
cord-261532-q923xxn2	102	7	and	and	CC
cord-261532-q923xxn2	102	8	the	the	DT
cord-261532-q923xxn2	102	9	shortest	short	JJS
cord-261532-q923xxn2	102	10	one	one	CD
cord-261532-q923xxn2	102	11	(	(	-LRB-
cord-261532-q923xxn2	102	12	19-mer	19-mer	CD
cord-261532-q923xxn2	102	13	or	or	CC
cord-261532-q923xxn2	102	14	21-mer	21-mer	CD
cord-261532-q923xxn2	102	15	)	)	-RRB-
cord-261532-q923xxn2	102	16	ended	end	VBD
cord-261532-q923xxn2	102	17	with	with	IN
cord-261532-q923xxn2	102	18	5	5	CD
cord-261532-q923xxn2	102	19	'	'	POS
cord-261532-q923xxn2	102	20	triphophorylation	triphophorylation	NN
cord-261532-q923xxn2	102	21	can	can	MD
cord-261532-q923xxn2	102	22	stimulate	stimulate	VB
cord-261532-q923xxn2	102	23	host	host	NN
cord-261532-q923xxn2	102	24	cells	cell	NNS
cord-261532-q923xxn2	102	25	to	to	TO
cord-261532-q923xxn2	102	26	induce	induce	VB
cord-261532-q923xxn2	102	27	massive	massive	JJ
cord-261532-q923xxn2	102	28	production	production	NN
cord-261532-q923xxn2	102	29	of	of	IN
cord-261532-q923xxn2	102	30	type	type	NN
cord-261532-q923xxn2	102	31	I	-PRON-	PRP
cord-261532-q923xxn2	102	32	interferons	interferon	NNS
cord-261532-q923xxn2	102	33	.	.	.
cord-261532-q923xxn2	103	1	However	however	RB
cord-261532-q923xxn2	103	2	,	,	,
cord-261532-q923xxn2	103	3	chemosynthetic	chemosynthetic	NNP
cord-261532-q923xxn2	103	4	5	5	CD
cord-261532-q923xxn2	103	5	'	'	POS
cord-261532-q923xxn2	103	6	triphophorylated	triphophorylated	JJ
cord-261532-q923xxn2	103	7	ssRNA	ssRNA	NNP
cord-261532-q923xxn2	103	8	has	have	VBZ
cord-261532-q923xxn2	103	9	no	no	DT
cord-261532-q923xxn2	103	10	effect	effect	NN
cord-261532-q923xxn2	103	11	on	on	IN
cord-261532-q923xxn2	103	12	the	the	DT
cord-261532-q923xxn2	103	13	upregulation	upregulation	NN
cord-261532-q923xxn2	103	14	of	of	IN
cord-261532-q923xxn2	103	15	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	103	16	cytokines	cytokine	NNS
cord-261532-q923xxn2	103	17	or	or	CC
cord-261532-q923xxn2	103	18	type	type	NN
cord-261532-q923xxn2	103	19	I	-PRON-	PRP
cord-261532-q923xxn2	103	20	interferons	interferon	NNS
cord-261532-q923xxn2	103	21	,	,	,
cord-261532-q923xxn2	103	22	while	while	IN
cord-261532-q923xxn2	103	23	dsRNA	dsrna	NN
cord-261532-q923xxn2	103	24	ended	end	VBD
cord-261532-q923xxn2	103	25	with	with	IN
cord-261532-q923xxn2	103	26	5	5	CD
cord-261532-q923xxn2	103	27	'	'	''
cord-261532-q923xxn2	103	28	tri	tri	JJ
cord-261532-q923xxn2	103	29	-	-	JJ
cord-261532-q923xxn2	103	30	or	or	CC
cord-261532-q923xxn2	103	31	single	single	JJ
cord-261532-q923xxn2	103	32	phosphorylated	phosphorylated	JJ
cord-261532-q923xxn2	103	33	,	,	,
cord-261532-q923xxn2	103	34	enable	enable	VB
cord-261532-q923xxn2	103	35	to	to	TO
cord-261532-q923xxn2	103	36	activate	activate	VB
cord-261532-q923xxn2	103	37	the	the	DT
cord-261532-q923xxn2	103	38	RIG	rig	NN
cord-261532-q923xxn2	104	1	-I	-i	DT
cord-261532-q923xxn2	104	2	signaling	signal	VBG
cord-261532-q923xxn2	104	3	Hornung	Hornung	NNP
cord-261532-q923xxn2	104	4	et	et	FW
cord-261532-q923xxn2	104	5	al	al	NNP
cord-261532-q923xxn2	104	6	.	.	NNP
cord-261532-q923xxn2	104	7	,	,	,
cord-261532-q923xxn2	104	8	2006	2006	CD
cord-261532-q923xxn2	104	9	)	)	-RRB-
cord-261532-q923xxn2	104	10	.	.	.
cord-261532-q923xxn2	105	1	Picornavirus	Picornavirus	NNP
cord-261532-q923xxn2	105	2	like	like	IN
cord-261532-q923xxn2	105	3	encephalomyocarditis	encephalomyocarditis	NNP
cord-261532-q923xxn2	105	4	virus	virus	NN
cord-261532-q923xxn2	105	5	(	(	-LRB-
cord-261532-q923xxn2	105	6	EMCV	EMCV	NNP
cord-261532-q923xxn2	105	7	)	)	-RRB-
cord-261532-q923xxn2	105	8	and	and	CC
cord-261532-q923xxn2	105	9	Polio	Polio	NNP
cord-261532-q923xxn2	105	10	virus	virus	NN
cord-261532-q923xxn2	105	11	are	be	VBP
cord-261532-q923xxn2	105	12	largely	largely	RB
cord-261532-q923xxn2	105	13	recognized	recognize	VBN
cord-261532-q923xxn2	105	14	by	by	IN
cord-261532-q923xxn2	105	15	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	105	16	.	.	.
cord-261532-q923xxn2	106	1	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	106	2	prefers	prefer	VBZ
cord-261532-q923xxn2	106	3	to	to	TO
cord-261532-q923xxn2	106	4	sense	sense	VB
cord-261532-q923xxn2	106	5	long	long	JJ
cord-261532-q923xxn2	106	6	strand	strand	NN
cord-261532-q923xxn2	106	7	dsRNA	dsrna	NN
cord-261532-q923xxn2	107	1	(	(	-LRB-
cord-261532-q923xxn2	107	2	more	more	JJR
cord-261532-q923xxn2	107	3	than	than	IN
cord-261532-q923xxn2	107	4	2	2	CD
cord-261532-q923xxn2	107	5	kb	kb	NNP
cord-261532-q923xxn2	107	6	)	)	-RRB-
cord-261532-q923xxn2	107	7	,	,	,
cord-261532-q923xxn2	107	8	and	and	CC
cord-261532-q923xxn2	107	9	the	the	DT
cord-261532-q923xxn2	107	10	intermediates	intermediate	NNS
cord-261532-q923xxn2	107	11	of	of	IN
cord-261532-q923xxn2	107	12	RNA	RNA	NNP
cord-261532-q923xxn2	107	13	virus	virus	NN
cord-261532-q923xxn2	107	14	replication	replication	NN
cord-261532-q923xxn2	107	15	in	in	IN
cord-261532-q923xxn2	107	16	EMCV	EMCV	NNP
cord-261532-q923xxn2	107	17	-	-	HYPH
cord-261532-q923xxn2	107	18	infected	infect	VBN
cord-261532-q923xxn2	107	19	cells	cell	NNS
cord-261532-q923xxn2	107	20	including	include	VBG
cord-261532-q923xxn2	107	21	the	the	DT
cord-261532-q923xxn2	107	22	higher	high	JJR
cord-261532-q923xxn2	107	23	-	-	HYPH
cord-261532-q923xxn2	107	24	structured	structured	JJ
cord-261532-q923xxn2	107	25	RNA	RNA	NNP
cord-261532-q923xxn2	107	26	consisted	consist	VBN
cord-261532-q923xxn2	107	27	of	of	IN
cord-261532-q923xxn2	107	28	dsRNA	dsrna	NN
cord-261532-q923xxn2	107	29	and	and	CC
cord-261532-q923xxn2	107	30	ssRNA	ssrna	NN
cord-261532-q923xxn2	107	31	is	be	VBZ
cord-261532-q923xxn2	107	32	able	able	JJ
cord-261532-q923xxn2	107	33	to	to	TO
cord-261532-q923xxn2	107	34	activate	activate	VB
cord-261532-q923xxn2	107	35	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	107	36	signaling	signal	VBG
cord-261532-q923xxn2	107	37	pathway	pathway	NN
cord-261532-q923xxn2	107	38	.	.	.
cord-261532-q923xxn2	108	1	Moreover	moreover	RB
cord-261532-q923xxn2	108	2	,	,	,
cord-261532-q923xxn2	108	3	both	both	DT
cord-261532-q923xxn2	108	4	West	West	NNP
cord-261532-q923xxn2	108	5	Nile	Nile	NNP
cord-261532-q923xxn2	108	6	virus	virus	NN
cord-261532-q923xxn2	108	7	and	and	CC
cord-261532-q923xxn2	108	8	dengue	dengue	NN
cord-261532-q923xxn2	108	9	virus	virus	NN
cord-261532-q923xxn2	108	10	can	can	MD
cord-261532-q923xxn2	108	11	activate	activate	VB
cord-261532-q923xxn2	108	12	RIG	rig	NN
cord-261532-q923xxn2	108	13	-	-	:
cord-261532-q923xxn2	108	14	I	-PRON-	PRP
cord-261532-q923xxn2	108	15	and	and	CC
cord-261532-q923xxn2	109	1	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	109	2	signaling	signal	VBG
cord-261532-q923xxn2	109	3	pathway	pathway	NN
cord-261532-q923xxn2	109	4	simultaneously	simultaneously	RB
cord-261532-q923xxn2	109	5	(	(	-LRB-
cord-261532-q923xxn2	109	6	Kato	Kato	NNP
cord-261532-q923xxn2	109	7	et	et	NNP
cord-261532-q923xxn2	109	8	al	al	NNP
cord-261532-q923xxn2	109	9	.	.	NNP
cord-261532-q923xxn2	109	10	,	,	,
cord-261532-q923xxn2	109	11	2008	2008	CD
cord-261532-q923xxn2	109	12	)	)	-RRB-
cord-261532-q923xxn2	109	13	.	.	.
cord-261532-q923xxn2	110	1	LGP2	LGP2	NNP
cord-261532-q923xxn2	110	2	,	,	,
cord-261532-q923xxn2	110	3	with	with	IN
cord-261532-q923xxn2	110	4	no	no	DT
cord-261532-q923xxn2	110	5	CARD	card	NN
cord-261532-q923xxn2	110	6	,	,	,
cord-261532-q923xxn2	110	7	was	be	VBD
cord-261532-q923xxn2	110	8	originally	originally	RB
cord-261532-q923xxn2	110	9	recognized	recognize	VBN
cord-261532-q923xxn2	110	10	as	as	IN
cord-261532-q923xxn2	110	11	a	a	DT
cord-261532-q923xxn2	110	12	negative	negative	JJ
cord-261532-q923xxn2	110	13	regulator	regulator	NN
cord-261532-q923xxn2	110	14	for	for	IN
cord-261532-q923xxn2	110	15	RIG	rig	NN
cord-261532-q923xxn2	110	16	-	-	:
cord-261532-q923xxn2	110	17	I	-PRON-	PRP
cord-261532-q923xxn2	110	18	and	and	CC
cord-261532-q923xxn2	111	1	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	111	2	(	(	-LRB-
cord-261532-q923xxn2	111	3	Saito	Saito	NNP
cord-261532-q923xxn2	111	4	et	et	FW
cord-261532-q923xxn2	111	5	al	al	NNP
cord-261532-q923xxn2	111	6	.	.	NNP
cord-261532-q923xxn2	111	7	,	,	,
cord-261532-q923xxn2	111	8	2007	2007	CD
cord-261532-q923xxn2	112	1	;	;	:
cord-261532-q923xxn2	112	2	Kato	Kato	NNP
cord-261532-q923xxn2	112	3	et	et	NNP
cord-261532-q923xxn2	112	4	al	al	NNP
cord-261532-q923xxn2	112	5	.	.	.
cord-261532-q923xxn2	113	1	,	,	,
cord-261532-q923xxn2	113	2	2008	2008	CD
cord-261532-q923xxn2	113	3	;	;	:
cord-261532-q923xxn2	113	4	Rothenfusser	Rothenfusser	NNP
cord-261532-q923xxn2	113	5	et	et	NNP
cord-261532-q923xxn2	113	6	al	al	NNP
cord-261532-q923xxn2	113	7	.	.	NNP
cord-261532-q923xxn2	113	8	,	,	,
cord-261532-q923xxn2	113	9	2012	2012	CD
cord-261532-q923xxn2	113	10	)	)	-RRB-
cord-261532-q923xxn2	113	11	.	.	.
cord-261532-q923xxn2	114	1	Controversially	controversially	RB
cord-261532-q923xxn2	114	2	,	,	,
cord-261532-q923xxn2	114	3	studies	study	NNS
cord-261532-q923xxn2	114	4	on	on	IN
cord-261532-q923xxn2	114	5	LGP2	LGP2	NNP
cord-261532-q923xxn2	114	6	-/mice	-/mice	.
cord-261532-q923xxn2	115	1	and	and	CC
cord-261532-q923xxn2	115	2	AT	AT	NNP
cord-261532-q923xxn2	115	3	-	-	HYPH
cord-261532-q923xxn2	115	4	Pase	Pase	NNP
cord-261532-q923xxn2	115	5	-	-	HYPH
cord-261532-q923xxn2	115	6	inactivated	inactivate	VBN
cord-261532-q923xxn2	115	7	mice	mouse	NNS
cord-261532-q923xxn2	115	8	unraveled	unravel	VBD
cord-261532-q923xxn2	115	9	a	a	DT
cord-261532-q923xxn2	115	10	positive	positive	JJ
cord-261532-q923xxn2	115	11	role	role	NN
cord-261532-q923xxn2	115	12	for	for	IN
cord-261532-q923xxn2	115	13	LGP2	LGP2	NNP
cord-261532-q923xxn2	115	14	in	in	IN
cord-261532-q923xxn2	115	15	response	response	NN
cord-261532-q923xxn2	115	16	to	to	IN
cord-261532-q923xxn2	115	17	RNA	RNA	NNP
cord-261532-q923xxn2	115	18	virus	virus	NN
cord-261532-q923xxn2	115	19	,	,	,
cord-261532-q923xxn2	115	20	with	with	IN
cord-261532-q923xxn2	115	21	the	the	DT
cord-261532-q923xxn2	115	22	capability	capability	NN
cord-261532-q923xxn2	115	23	of	of	IN
cord-261532-q923xxn2	115	24	promoting	promote	VBG
cord-261532-q923xxn2	115	25	the	the	DT
cord-261532-q923xxn2	115	26	interaction	interaction	NN
cord-261532-q923xxn2	115	27	of	of	IN
cord-261532-q923xxn2	115	28	RIG	rig	NN
cord-261532-q923xxn2	115	29	-	-	:
cord-261532-q923xxn2	115	30	I	I	NNP
cord-261532-q923xxn2	115	31	/	/	SYM
cord-261532-q923xxn2	115	32	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	115	33	with	with	IN
cord-261532-q923xxn2	115	34	RNA	RNA	NNP
cord-261532-q923xxn2	115	35	(	(	-LRB-
cord-261532-q923xxn2	115	36	Satoh	Satoh	NNP
cord-261532-q923xxn2	115	37	et	et	FW
cord-261532-q923xxn2	115	38	al	al	NNP
cord-261532-q923xxn2	115	39	.	.	NNP
cord-261532-q923xxn2	115	40	,	,	,
cord-261532-q923xxn2	115	41	2010	2010	CD
cord-261532-q923xxn2	115	42	)	)	-RRB-
cord-261532-q923xxn2	115	43	.	.	.
cord-261532-q923xxn2	116	1	In	in	IN
cord-261532-q923xxn2	116	2	RNA	RNA	NNP
cord-261532-q923xxn2	116	3	virus	virus	NN
cord-261532-q923xxn2	116	4	-	-	HYPH
cord-261532-q923xxn2	116	5	invaded	invade	VBN
cord-261532-q923xxn2	116	6	cells	cell	NNS
cord-261532-q923xxn2	116	7	,	,	,
cord-261532-q923xxn2	116	8	RIG	rig	NN
cord-261532-q923xxn2	116	9	-	-	:
cord-261532-q923xxn2	116	10	I	I	NNP
cord-261532-q923xxn2	116	11	and	and	CC
cord-261532-q923xxn2	116	12	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	116	13	experience	experience	NN
cord-261532-q923xxn2	116	14	conformational	conformational	JJ
cord-261532-q923xxn2	116	15	changes	change	NNS
cord-261532-q923xxn2	116	16	during	during	IN
cord-261532-q923xxn2	116	17	RNA	rna	NN
cord-261532-q923xxn2	116	18	-	-	HYPH
cord-261532-q923xxn2	116	19	binding	bind	VBG
cord-261532-q923xxn2	116	20	and	and	CC
cord-261532-q923xxn2	116	21	expose	expose	VB
cord-261532-q923xxn2	116	22	their	-PRON-	PRP$
cord-261532-q923xxn2	116	23	CARDs	card	NNS
cord-261532-q923xxn2	116	24	to	to	TO
cord-261532-q923xxn2	116	25	recruit	recruit	VB
cord-261532-q923xxn2	116	26	MAVS	MAVS	NNP
cord-261532-q923xxn2	116	27	,	,	,
cord-261532-q923xxn2	116	28	which	which	WDT
cord-261532-q923xxn2	116	29	activates	activate	VBZ
cord-261532-q923xxn2	116	30	TRAF3	traf3	NN
cord-261532-q923xxn2	116	31	/	/	SYM
cord-261532-q923xxn2	116	32	TBK1/	TBK1/	NNP
cord-261532-q923xxn2	116	33	IKK	IKK	NNP
cord-261532-q923xxn2	116	34	-	-	HYPH
cord-261532-q923xxn2	116	35	i	i	NNP
cord-261532-q923xxn2	116	36	and	and	CC
cord-261532-q923xxn2	116	37	then	then	RB
cord-261532-q923xxn2	116	38	IRF3	IRF3	NNP
cord-261532-q923xxn2	116	39	/	/	SYM
cord-261532-q923xxn2	116	40	IRF7	IRF7	NNP
cord-261532-q923xxn2	116	41	,	,	,
cord-261532-q923xxn2	116	42	resulting	result	VBG
cord-261532-q923xxn2	116	43	in	in	IN
cord-261532-q923xxn2	116	44	the	the	DT
cord-261532-q923xxn2	116	45	expression	expression	NN
cord-261532-q923xxn2	116	46	of	of	IN
cord-261532-q923xxn2	116	47	type	type	NN
cord-261532-q923xxn2	116	48	I	-PRON-	PRP
cord-261532-q923xxn2	116	49	interferons	interferon	NNS
cord-261532-q923xxn2	116	50	.	.	.
cord-261532-q923xxn2	117	1	Meanwhile	meanwhile	RB
cord-261532-q923xxn2	117	2	,	,	,
cord-261532-q923xxn2	117	3	MAVS	MAVS	NNP
cord-261532-q923xxn2	117	4	induces	induce	VBZ
cord-261532-q923xxn2	117	5	NF	nf	NN
cord-261532-q923xxn2	117	6	-	-	HYPH
cord-261532-q923xxn2	117	7	κB	κB	NNP
cord-261532-q923xxn2	117	8	-	-	HYPH
cord-261532-q923xxn2	117	9	dependent	dependent	JJ
cord-261532-q923xxn2	117	10	expression	expression	NN
cord-261532-q923xxn2	117	11	of	of	IN
cord-261532-q923xxn2	117	12	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	117	13	factors	factor	NNS
cord-261532-q923xxn2	117	14	by	by	IN
cord-261532-q923xxn2	117	15	recruiting	recruit	VBG
cord-261532-q923xxn2	117	16	the	the	DT
cord-261532-q923xxn2	117	17	TRADD	TRADD	NNP
cord-261532-q923xxn2	117	18	/	/	SYM
cord-261532-q923xxn2	117	19	FADD	FADD	NNP
cord-261532-q923xxn2	117	20	/	/	SYM
cord-261532-q923xxn2	117	21	Caspase-8	Caspase-8	NNP
cord-261532-q923xxn2	117	22	/	/	SYM
cord-261532-q923xxn2	117	23	Caspase-10	caspase-10	NN
cord-261532-q923xxn2	117	24	complex	complex	NN
cord-261532-q923xxn2	117	25	(	(	-LRB-
cord-261532-q923xxn2	117	26	Fig	fig	NN
cord-261532-q923xxn2	117	27	.	.	NNP
cord-261532-q923xxn2	117	28	2	2	CD
cord-261532-q923xxn2	117	29	)	)	-RRB-
cord-261532-q923xxn2	117	30	.	.	.
cord-261532-q923xxn2	118	1	During	during	IN
cord-261532-q923xxn2	118	2	activation	activation	NN
cord-261532-q923xxn2	118	3	,	,	,
cord-261532-q923xxn2	118	4	RIG	rig	NN
cord-261532-q923xxn2	118	5	-	-	:
cord-261532-q923xxn2	118	6	I	-PRON-	PRP
cord-261532-q923xxn2	118	7	undergoes	undergo	VBZ
cord-261532-q923xxn2	118	8	K	K	NNP
cord-261532-q923xxn2	118	9	63	63	CD
cord-261532-q923xxn2	118	10	-linked	-linked	CD
cord-261532-q923xxn2	118	11	ubiquitination	ubiquitination	NN
cord-261532-q923xxn2	118	12	on	on	IN
cord-261532-q923xxn2	118	13	its	-PRON-	PRP$
cord-261532-q923xxn2	118	14	CARD	card	NN
cord-261532-q923xxn2	118	15	by	by	IN
cord-261532-q923xxn2	118	16	tripartite	tripartite	JJ
cord-261532-q923xxn2	118	17	motif	motif	NN
cord-261532-q923xxn2	118	18	containing	contain	VBG
cord-261532-q923xxn2	118	19	25	25	CD
cord-261532-q923xxn2	118	20	(	(	-LRB-
cord-261532-q923xxn2	118	21	TRIM25	trim25	NN
cord-261532-q923xxn2	118	22	)	)	-RRB-
cord-261532-q923xxn2	119	1	and	and	CC
cord-261532-q923xxn2	119	2	RNF135	RNF135	NNS
cord-261532-q923xxn2	120	1	(	(	-LRB-
cord-261532-q923xxn2	120	2	Zeng	Zeng	NNP
cord-261532-q923xxn2	120	3	et	et	NNP
cord-261532-q923xxn2	120	4	al	al	NNP
cord-261532-q923xxn2	120	5	.	.	NNP
cord-261532-q923xxn2	120	6	,	,	,
cord-261532-q923xxn2	120	7	2010	2010	CD
cord-261532-q923xxn2	120	8	)	)	-RRB-
cord-261532-q923xxn2	120	9	,	,	.
cord-261532-q923xxn2	121	1	whereas	whereas	IN
cord-261532-q923xxn2	121	2	RNF125	RNF125	NNP
cord-261532-q923xxn2	121	3	downregulates	downregulate	VBZ
cord-261532-q923xxn2	121	4	RIG	rig	NN
cord-261532-q923xxn2	121	5	-	-	:
cord-261532-q923xxn2	121	6	I	-PRON-	PRP
cord-261532-q923xxn2	121	7	signaling	signal	VBG
cord-261532-q923xxn2	121	8	through	through	IN
cord-261532-q923xxn2	121	9	K	K	NNP
cord-261532-q923xxn2	121	10	48	48	CD
cord-261532-q923xxn2	122	1	-linked	-linked	JJ
cord-261532-q923xxn2	122	2	ubiquitination	ubiquitination	NN
cord-261532-q923xxn2	122	3	and	and	CC
cord-261532-q923xxn2	122	4	degradation	degradation	NN
cord-261532-q923xxn2	123	1	(	(	-LRB-
cord-261532-q923xxn2	123	2	Arimoto	Arimoto	NNP
cord-261532-q923xxn2	123	3	et	et	NNP
cord-261532-q923xxn2	123	4	al	al	NNP
cord-261532-q923xxn2	123	5	.	.	NNP
cord-261532-q923xxn2	123	6	,	,	,
cord-261532-q923xxn2	123	7	2007	2007	CD
cord-261532-q923xxn2	123	8	)	)	-RRB-
cord-261532-q923xxn2	123	9	.	.	.
cord-261532-q923xxn2	124	1	The	the	DT
cord-261532-q923xxn2	124	2	CARD	card	NN
cord-261532-q923xxn2	124	3	domains	domain	NNS
cord-261532-q923xxn2	124	4	of	of	IN
cord-261532-q923xxn2	124	5	the	the	DT
cord-261532-q923xxn2	124	6	RNA	RNA	NNP
cord-261532-q923xxn2	124	7	sensors	sensor	NNS
cord-261532-q923xxn2	124	8	RIG	rig	NN
cord-261532-q923xxn2	124	9	-	-	:
cord-261532-q923xxn2	124	10	I	-PRON-	PRP
cord-261532-q923xxn2	124	11	/Mda-5	/Mda-5	NNP
cord-261532-q923xxn2	124	12	bind	bind	VBP
cord-261532-q923xxn2	124	13	to	to	IN
cord-261532-q923xxn2	124	14	K63-polyubiquitin	K63-polyubiquitin	NNP
cord-261532-q923xxn2	124	15	chains	chain	NNS
cord-261532-q923xxn2	124	16	,	,	,
cord-261532-q923xxn2	124	17	and	and	CC
cord-261532-q923xxn2	124	18	sequentially	sequentially	RB
cord-261532-q923xxn2	124	19	form	form	VB
cord-261532-q923xxn2	124	20	the	the	DT
cord-261532-q923xxn2	124	21	RIG	rig	NN
cord-261532-q923xxn2	124	22	-	-	:
cord-261532-q923xxn2	124	23	I	I	NNP
cord-261532-q923xxn2	124	24	or	or	CC
cord-261532-q923xxn2	124	25	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	124	26	oligomers	oligomer	NNS
cord-261532-q923xxn2	124	27	,	,	,
cord-261532-q923xxn2	124	28	which	which	WDT
cord-261532-q923xxn2	124	29	is	be	VBZ
cord-261532-q923xxn2	124	30	essential	essential	JJ
cord-261532-q923xxn2	124	31	for	for	IN
cord-261532-q923xxn2	124	32	IRF3	IRF3	NNP
cord-261532-q923xxn2	124	33	activation	activation	NN
cord-261532-q923xxn2	124	34	and	and	CC
cord-261532-q923xxn2	124	35	signaling	signal	VBG
cord-261532-q923xxn2	124	36	regulation	regulation	NN
cord-261532-q923xxn2	125	1	(	(	-LRB-
cord-261532-q923xxn2	125	2	Jiang	Jiang	NNP
cord-261532-q923xxn2	125	3	et	et	FW
cord-261532-q923xxn2	125	4	al	al	NNP
cord-261532-q923xxn2	125	5	.	.	NNP
cord-261532-q923xxn2	125	6	,	,	,
cord-261532-q923xxn2	125	7	2012	2012	CD
cord-261532-q923xxn2	125	8	)	)	-RRB-
cord-261532-q923xxn2	125	9	.	.	.
cord-261532-q923xxn2	126	1	K63-polyubiquitinanted	K63-polyubiquitinanted	NNP
cord-261532-q923xxn2	126	2	RIG-	RIG-	NNP
cord-261532-q923xxn2	127	1	I	-PRON-	PRP
cord-261532-q923xxn2	127	2	oligomers	oligomer	NNS
cord-261532-q923xxn2	127	3	are	be	VBP
cord-261532-q923xxn2	127	4	highly	highly	RB
cord-261532-q923xxn2	127	5	potent	potent	JJ
cord-261532-q923xxn2	127	6	in	in	IN
cord-261532-q923xxn2	127	7	aggregating	aggregate	VBG
cord-261532-q923xxn2	127	8	and	and	CC
cord-261532-q923xxn2	127	9	activating	activate	VBG
cord-261532-q923xxn2	127	10	MAVS	MAVS	NNPS
cord-261532-q923xxn2	127	11	on	on	IN
cord-261532-q923xxn2	127	12	the	the	DT
cord-261532-q923xxn2	127	13	mitochondrial	mitochondrial	JJ
cord-261532-q923xxn2	127	14	memberane	memberane	NN
cord-261532-q923xxn2	127	15	through	through	IN
cord-261532-q923xxn2	127	16	a	a	DT
cord-261532-q923xxn2	127	17	prion	prion	NN
cord-261532-q923xxn2	127	18	-	-	HYPH
cord-261532-q923xxn2	127	19	like	like	JJ
cord-261532-q923xxn2	127	20	manner	manner	NN
cord-261532-q923xxn2	127	21	,	,	,
cord-261532-q923xxn2	127	22	propagating	propagate	VBG
cord-261532-q923xxn2	127	23	the	the	DT
cord-261532-q923xxn2	127	24	antiviral	antiviral	JJ
cord-261532-q923xxn2	127	25	signaling	signaling	NN
cord-261532-q923xxn2	127	26	cascade	cascade	NN
cord-261532-q923xxn2	127	27	(	(	-LRB-
cord-261532-q923xxn2	127	28	Hou	Hou	NNP
cord-261532-q923xxn2	127	29	et	et	FW
cord-261532-q923xxn2	127	30	al	al	NNP
cord-261532-q923xxn2	127	31	.	.	NNP
cord-261532-q923xxn2	127	32	,	,	,
cord-261532-q923xxn2	127	33	2011	2011	CD
cord-261532-q923xxn2	127	34	)	)	-RRB-
cord-261532-q923xxn2	127	35	.	.	.
cord-261532-q923xxn2	128	1	According	accord	VBG
cord-261532-q923xxn2	128	2	to	to	IN
cord-261532-q923xxn2	128	3	a	a	DT
cord-261532-q923xxn2	128	4	recent	recent	JJ
cord-261532-q923xxn2	128	5	work	work	NN
cord-261532-q923xxn2	128	6	,	,	,
cord-261532-q923xxn2	128	7	a	a	DT
cord-261532-q923xxn2	128	8	Ser	Ser	NNP
cord-261532-q923xxn2	128	9	/	/	SYM
cord-261532-q923xxn2	128	10	Thr	Thr	NNP
cord-261532-q923xxn2	128	11	phosphatase	phosphatase	NN
cord-261532-q923xxn2	128	12	eyes	eye	NNS
cord-261532-q923xxn2	128	13	absent	absent	JJ
cord-261532-q923xxn2	128	14	4	4	CD
cord-261532-q923xxn2	128	15	(	(	-LRB-
cord-261532-q923xxn2	128	16	EYA4	EYA4	NNP
cord-261532-q923xxn2	128	17	)	)	-RRB-
cord-261532-q923xxn2	128	18	,	,	,
cord-261532-q923xxn2	128	19	is	be	VBZ
cord-261532-q923xxn2	128	20	found	find	VBN
cord-261532-q923xxn2	128	21	to	to	TO
cord-261532-q923xxn2	128	22	interact	interact	VB
cord-261532-q923xxn2	128	23	with	with	IN
cord-261532-q923xxn2	128	24	MAVS	MAVS	NNPS
cord-261532-q923xxn2	128	25	and	and	CC
cord-261532-q923xxn2	128	26	is	be	VBZ
cord-261532-q923xxn2	128	27	es-	es-	NN
cord-261532-q923xxn2	129	1	Figure	figure	NN
cord-261532-q923xxn2	129	2	2	2	CD
cord-261532-q923xxn2	129	3	.	.	.
cord-261532-q923xxn2	130	1	RLR	RLR	NNP
cord-261532-q923xxn2	130	2	-	-	HYPH
cord-261532-q923xxn2	130	3	MAVS	MAVS	NNP
cord-261532-q923xxn2	130	4	signaling	signal	VBG
cord-261532-q923xxn2	130	5	pathways	pathway	NNS
cord-261532-q923xxn2	130	6	induced	induce	VBN
cord-261532-q923xxn2	130	7	by	by	IN
cord-261532-q923xxn2	130	8	RNA	RNA	NNP
cord-261532-q923xxn2	130	9	viruses	virus	NNS
cord-261532-q923xxn2	130	10	.	.	.
cord-261532-q923xxn2	131	1	RIG	rig	NN
cord-261532-q923xxn2	131	2	-	-	:
cord-261532-q923xxn2	131	3	I	I	NNP
cord-261532-q923xxn2	131	4	and	and	CC
cord-261532-q923xxn2	131	5	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	131	6	detect	detect	VB
cord-261532-q923xxn2	131	7	short	short	JJ
cord-261532-q923xxn2	131	8	dsRNA	dsrna	NN
cord-261532-q923xxn2	132	1	with	with	IN
cord-261532-q923xxn2	132	2	5	5	CD
cord-261532-q923xxn2	132	3	'	'	''
cord-261532-q923xxn2	132	4	triphosphate	triphosphate	NN
cord-261532-q923xxn2	132	5	ends	end	VBZ
cord-261532-q923xxn2	132	6	and	and	CC
cord-261532-q923xxn2	132	7	long	long	JJ
cord-261532-q923xxn2	132	8	dsRNA	dsrna	NN
cord-261532-q923xxn2	132	9	,	,	,
cord-261532-q923xxn2	132	10	respectively	respectively	RB
cord-261532-q923xxn2	132	11	.	.	.
cord-261532-q923xxn2	133	1	By	by	IN
cord-261532-q923xxn2	133	2	CARD	card	NN
cord-261532-q923xxn2	133	3	domain	domain	NN
cord-261532-q923xxn2	133	4	interactions	interaction	NNS
cord-261532-q923xxn2	133	5	,	,	,
cord-261532-q923xxn2	133	6	they	-PRON-	PRP
cord-261532-q923xxn2	133	7	recruit	recruit	VBP
cord-261532-q923xxn2	133	8	MAVS	MAVS	NNP
cord-261532-q923xxn2	133	9	and	and	CC
cord-261532-q923xxn2	133	10	in	in	IN
cord-261532-q923xxn2	133	11	turn	turn	NN
cord-261532-q923xxn2	133	12	activate	activate	VBP
cord-261532-q923xxn2	133	13	IRF3	IRF3	NNP
cord-261532-q923xxn2	133	14	/	/	SYM
cord-261532-q923xxn2	133	15	IRF7	IRF7	NNP
cord-261532-q923xxn2	133	16	through	through	IN
cord-261532-q923xxn2	133	17	EYA4	EYA4	NNP
cord-261532-q923xxn2	133	18	,	,	,
cord-261532-q923xxn2	133	19	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	133	20	,	,	,
cord-261532-q923xxn2	133	21	NF	NF	NNP
cord-261532-q923xxn2	133	22	-	-	HYPH
cord-261532-q923xxn2	133	23	κB	κB	NNP
cord-261532-q923xxn2	134	1	activating	activate	VBG
cord-261532-q923xxn2	134	2	kinase	kinase	NN
cord-261532-q923xxn2	134	3	-	-	HYPH
cord-261532-q923xxn2	134	4	associated	associate	VBN
cord-261532-q923xxn2	134	5	protein	protein	NN
cord-261532-q923xxn2	134	6	1	1	CD
cord-261532-q923xxn2	135	1	(	(	-LRB-
cord-261532-q923xxn2	135	2	NAP1)/similar	nap1)/similar	JJ
cord-261532-q923xxn2	135	3	to	to	IN
cord-261532-q923xxn2	135	4	NAP1	NAP1	NNP
cord-261532-q923xxn2	136	1	TBK1	TBK1	NNP
cord-261532-q923xxn2	136	2	adaptor	adaptor	NN
cord-261532-q923xxn2	136	3	(	(	-LRB-
cord-261532-q923xxn2	136	4	STINTBAD	STINTBAD	NNP
cord-261532-q923xxn2	136	5	)	)	-RRB-
cord-261532-q923xxn2	136	6	and	and	CC
cord-261532-q923xxn2	136	7	TBK1	TBK1	NNP
cord-261532-q923xxn2	136	8	/	/	SYM
cord-261532-q923xxn2	136	9	IKK-	IKK-	NNP
cord-261532-q923xxn2	137	1	i	i	PRP
cord-261532-q923xxn2	137	2	signaling	signal	VBG
cord-261532-q923xxn2	137	3	cascades	cascade	NNS
cord-261532-q923xxn2	137	4	,	,	,
cord-261532-q923xxn2	137	5	leading	lead	VBG
cord-261532-q923xxn2	137	6	to	to	IN
cord-261532-q923xxn2	137	7	the	the	DT
cord-261532-q923xxn2	137	8	expression	expression	NN
cord-261532-q923xxn2	137	9	of	of	IN
cord-261532-q923xxn2	137	10	type	type	NN
cord-261532-q923xxn2	137	11	І	і	CD
cord-261532-q923xxn2	137	12	interferon	interferon	NN
cord-261532-q923xxn2	137	13	genes	gene	NNS
cord-261532-q923xxn2	137	14	.	.	.
cord-261532-q923xxn2	138	1	Meanwhile	meanwhile	RB
cord-261532-q923xxn2	138	2	,	,	,
cord-261532-q923xxn2	138	3	MAVS	MAVS	NNP
cord-261532-q923xxn2	138	4	activates	activate	VBZ
cord-261532-q923xxn2	138	5	NF	NF	NNP
cord-261532-q923xxn2	138	6	-	-	HYPH
cord-261532-q923xxn2	138	7	κB	κB	NNP
cord-261532-q923xxn2	139	1	via	via	IN
cord-261532-q923xxn2	139	2	the	the	DT
cord-261532-q923xxn2	139	3	TRADD	TRADD	NNP
cord-261532-q923xxn2	139	4	,	,	,
cord-261532-q923xxn2	139	5	FADD	FADD	NNP
cord-261532-q923xxn2	139	6	,	,	,
cord-261532-q923xxn2	139	7	Caspase-8/-10	caspase-8/-10	IN
cord-261532-q923xxn2	139	8	signaling	signal	VBG
cord-261532-q923xxn2	139	9	cascades	cascade	NNS
cord-261532-q923xxn2	139	10	,	,	,
cord-261532-q923xxn2	139	11	resulting	result	VBG
cord-261532-q923xxn2	139	12	in	in	IN
cord-261532-q923xxn2	139	13	the	the	DT
cord-261532-q923xxn2	139	14	production	production	NN
cord-261532-q923xxn2	139	15	of	of	IN
cord-261532-q923xxn2	139	16	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	139	17	cytokines	cytokine	NNS
cord-261532-q923xxn2	139	18	.	.	.
cord-261532-q923xxn2	140	1	LGP2	LGP2	NNP
cord-261532-q923xxn2	140	2	functions	function	NNS
cord-261532-q923xxn2	140	3	as	as	IN
cord-261532-q923xxn2	140	4	a	a	DT
cord-261532-q923xxn2	140	5	positive	positive	JJ
cord-261532-q923xxn2	140	6	regulator	regulator	NN
cord-261532-q923xxn2	140	7	of	of	IN
cord-261532-q923xxn2	140	8	RIG	rig	NN
cord-261532-q923xxn2	140	9	-	-	:
cord-261532-q923xxn2	140	10	I	I	NNP
cord-261532-q923xxn2	140	11	and	and	CC
cord-261532-q923xxn2	140	12	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	140	13	signaling	signal	VBG
cord-261532-q923xxn2	140	14	pathways	pathway	NNS
cord-261532-q923xxn2	140	15	.	.	.
cord-261532-q923xxn2	141	1	Activation	activation	NN
cord-261532-q923xxn2	141	2	of	of	IN
cord-261532-q923xxn2	141	3	RIG	rig	NN
cord-261532-q923xxn2	141	4	-	-	:
cord-261532-q923xxn2	141	5	I	-PRON-	PRP
cord-261532-q923xxn2	141	6	is	be	VBZ
cord-261532-q923xxn2	141	7	positively	positively	RB
cord-261532-q923xxn2	141	8	and	and	CC
cord-261532-q923xxn2	141	9	negatively	negatively	RB
cord-261532-q923xxn2	141	10	regulated	regulate	VBN
cord-261532-q923xxn2	141	11	by	by	IN
cord-261532-q923xxn2	141	12	ubiquitin	ubiquitin	NN
cord-261532-q923xxn2	141	13	ligases	ligase	NNS
cord-261532-q923xxn2	141	14	TRIM25	TRIM25	NNP
cord-261532-q923xxn2	141	15	and	and	CC
cord-261532-q923xxn2	141	16	RNF125	RNF125	NNP
cord-261532-q923xxn2	141	17	,	,	,
cord-261532-q923xxn2	141	18	respectively	respectively	RB
cord-261532-q923xxn2	141	19	.	.	.
cord-261532-q923xxn2	142	1	RLR	RLR	NNP
cord-261532-q923xxn2	142	2	signaling	signaling	NN
cord-261532-q923xxn2	142	3	requires	require	VBZ
cord-261532-q923xxn2	142	4	polyubiquitination	polyubiquitination	NN
cord-261532-q923xxn2	142	5	of	of	IN
cord-261532-q923xxn2	142	6	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	142	7	,	,	,
cord-261532-q923xxn2	142	8	which	which	WDT
cord-261532-q923xxn2	142	9	can	can	MD
cord-261532-q923xxn2	142	10	be	be	VB
cord-261532-q923xxn2	142	11	removed	remove	VBN
cord-261532-q923xxn2	142	12	by	by	IN
cord-261532-q923xxn2	142	13	a	a	DT
cord-261532-q923xxn2	142	14	deubiquitinase	deubiquitinase	NN
cord-261532-q923xxn2	142	15	,	,	,
cord-261532-q923xxn2	142	16	deubiquitinating	deubiquitinating	NN
cord-261532-q923xxn2	142	17	enzyme	enzyme	NN
cord-261532-q923xxn2	142	18	A	a	DT
cord-261532-q923xxn2	142	19	(	(	-LRB-
cord-261532-q923xxn2	142	20	DUBA	DUBA	NNP
cord-261532-q923xxn2	142	21	)	)	-RRB-
cord-261532-q923xxn2	142	22	.	.	.
cord-261532-q923xxn2	143	1	Cell	cell	NN
cord-261532-q923xxn2	143	2	sential	sential	JJ
cord-261532-q923xxn2	143	3	for	for	IN
cord-261532-q923xxn2	143	4	the	the	DT
cord-261532-q923xxn2	143	5	production	production	NN
cord-261532-q923xxn2	143	6	of	of	IN
cord-261532-q923xxn2	143	7	IFN	IFN	NNP
cord-261532-q923xxn2	143	8	-	-	HYPH
cord-261532-q923xxn2	143	9	β	β	NNP
cord-261532-q923xxn2	143	10	(	(	-LRB-
cord-261532-q923xxn2	143	11	Okabe	Okabe	NNP
cord-261532-q923xxn2	143	12	et	et	NNP
cord-261532-q923xxn2	143	13	al	al	NNP
cord-261532-q923xxn2	143	14	.	.	NNP
cord-261532-q923xxn2	143	15	,	,	,
cord-261532-q923xxn2	143	16	2009	2009	CD
cord-261532-q923xxn2	143	17	)	)	-RRB-
cord-261532-q923xxn2	143	18	.	.	.
cord-261532-q923xxn2	144	1	A	a	DT
cord-261532-q923xxn2	144	2	member	member	NN
cord-261532-q923xxn2	144	3	of	of	IN
cord-261532-q923xxn2	144	4	the	the	DT
cord-261532-q923xxn2	144	5	NLR	NLR	NNP
cord-261532-q923xxn2	144	6	family	family	NN
cord-261532-q923xxn2	144	7	,	,	,
cord-261532-q923xxn2	144	8	NLRX1	NLRX1	NNP
cord-261532-q923xxn2	144	9	(	(	-LRB-
cord-261532-q923xxn2	144	10	or	or	CC
cord-261532-q923xxn2	144	11	NOD9	NOD9	NNP
cord-261532-q923xxn2	144	12	)	)	-RRB-
cord-261532-q923xxn2	144	13	colocalizes	colocalize	VBZ
cord-261532-q923xxn2	144	14	with	with	IN
cord-261532-q923xxn2	144	15	MAVS	MAVS	NNPS
cord-261532-q923xxn2	144	16	at	at	IN
cord-261532-q923xxn2	144	17	mitochondria	mitochondrion	NNS
cord-261532-q923xxn2	144	18	and	and	CC
cord-261532-q923xxn2	144	19	negatively	negatively	RB
cord-261532-q923xxn2	144	20	regulates	regulate	VBZ
cord-261532-q923xxn2	144	21	MAVS	MAVS	NNP
cord-261532-q923xxn2	144	22	-	-	HYPH
cord-261532-q923xxn2	144	23	dependent	dependent	JJ
cord-261532-q923xxn2	144	24	antiviral	antiviral	JJ
cord-261532-q923xxn2	144	25	immune	immune	JJ
cord-261532-q923xxn2	144	26	responses	response	NNS
cord-261532-q923xxn2	145	1	(	(	-LRB-
cord-261532-q923xxn2	145	2	Moore	Moore	NNP
cord-261532-q923xxn2	145	3	et	et	NNP
cord-261532-q923xxn2	145	4	al	al	NNP
cord-261532-q923xxn2	145	5	.	.	NNP
cord-261532-q923xxn2	145	6	,	,	,
cord-261532-q923xxn2	145	7	2008	2008	CD
cord-261532-q923xxn2	145	8	)	)	-RRB-
cord-261532-q923xxn2	145	9	.	.	.
cord-261532-q923xxn2	146	1	Besides	besides	RB
cord-261532-q923xxn2	146	2	,	,	,
cord-261532-q923xxn2	146	3	the	the	DT
cord-261532-q923xxn2	146	4	RLR	RLR	NNP
cord-261532-q923xxn2	146	5	pathway	pathway	NN
cord-261532-q923xxn2	146	6	can	can	MD
cord-261532-q923xxn2	146	7	be	be	VB
cord-261532-q923xxn2	146	8	downregulated	downregulate	VBN
cord-261532-q923xxn2	146	9	by	by	IN
cord-261532-q923xxn2	146	10	autophagosome	autophagosome	NN
cord-261532-q923xxn2	146	11	-	-	HYPH
cord-261532-q923xxn2	146	12	related	relate	VBN
cord-261532-q923xxn2	146	13	proteins	protein	NNS
cord-261532-q923xxn2	146	14	such	such	JJ
cord-261532-q923xxn2	146	15	as	as	IN
cord-261532-q923xxn2	146	16	autophagy	autophagy	NN
cord-261532-q923xxn2	146	17	-	-	HYPH
cord-261532-q923xxn2	146	18	related	relate	VBN
cord-261532-q923xxn2	146	19	gene	gene	NN
cord-261532-q923xxn2	146	20	5	5	CD
cord-261532-q923xxn2	147	1	(	(	-LRB-
cord-261532-q923xxn2	147	2	ATG5	ATG5	NNP
cord-261532-q923xxn2	147	3	)	)	-RRB-
cord-261532-q923xxn2	147	4	and	and	CC
cord-261532-q923xxn2	147	5	ATG16L1	ATG16L1	NNS
cord-261532-q923xxn2	147	6	.	.	.
cord-261532-q923xxn2	148	1	When	when	WRB
cord-261532-q923xxn2	148	2	mouse	mouse	NN
cord-261532-q923xxn2	148	3	embryonic	embryonic	JJ
cord-261532-q923xxn2	148	4	fibroblasts	fibroblast	NNS
cord-261532-q923xxn2	148	5	(	(	-LRB-
cord-261532-q923xxn2	148	6	MEFs	mef	NNS
cord-261532-q923xxn2	148	7	)	)	-RRB-
cord-261532-q923xxn2	148	8	and	and	CC
cord-261532-q923xxn2	148	9	conventional	conventional	JJ
cord-261532-q923xxn2	148	10	DCs	dc	NNS
cord-261532-q923xxn2	148	11	(	(	-LRB-
cord-261532-q923xxn2	148	12	cDCs	cDCs	NNP
cord-261532-q923xxn2	148	13	)	)	-RRB-
cord-261532-q923xxn2	148	14	lacking	lack	VBG
cord-261532-q923xxn2	148	15	autophagosome	autophagosome	NNP
cord-261532-q923xxn2	148	16	are	be	VBP
cord-261532-q923xxn2	148	17	infected	infect	VBN
cord-261532-q923xxn2	148	18	with	with	IN
cord-261532-q923xxn2	148	19	RNA	RNA	NNP
cord-261532-q923xxn2	148	20	viruses	virus	NNS
cord-261532-q923xxn2	148	21	,	,	,
cord-261532-q923xxn2	148	22	MAVS	MAVS	NNP
cord-261532-q923xxn2	148	23	-	-	HYPH
cord-261532-q923xxn2	148	24	resident	resident	NN
cord-261532-q923xxn2	148	25	mitochondria	mitochondrion	NNS
cord-261532-q923xxn2	148	26	will	will	MD
cord-261532-q923xxn2	148	27	dysfunction	dysfunction	VB
cord-261532-q923xxn2	148	28	and	and	CC
cord-261532-q923xxn2	148	29	produce	produce	VB
cord-261532-q923xxn2	148	30	massive	massive	JJ
cord-261532-q923xxn2	148	31	reactive	reactive	JJ
cord-261532-q923xxn2	148	32	oxygen	oxygen	NN
cord-261532-q923xxn2	148	33	species	specie	NNS
cord-261532-q923xxn2	148	34	(	(	-LRB-
cord-261532-q923xxn2	148	35	ROS	ROS	NNP
cord-261532-q923xxn2	148	36	)	)	-RRB-
cord-261532-q923xxn2	148	37	,	,	,
cord-261532-q923xxn2	148	38	the	the	DT
cord-261532-q923xxn2	148	39	release	release	NN
cord-261532-q923xxn2	148	40	of	of	IN
cord-261532-q923xxn2	148	41	which	which	WDT
cord-261532-q923xxn2	148	42	in	in	IN
cord-261532-q923xxn2	148	43	turn	turn	NN
cord-261532-q923xxn2	148	44	triggers	trigger	VBZ
cord-261532-q923xxn2	148	45	the	the	DT
cord-261532-q923xxn2	148	46	induction	induction	NN
cord-261532-q923xxn2	148	47	of	of	IN
cord-261532-q923xxn2	148	48	type	type	NN
cord-261532-q923xxn2	148	49	I	-PRON-	PRP
cord-261532-q923xxn2	148	50	interferons	interferon	NNS
cord-261532-q923xxn2	148	51	.	.	.
cord-261532-q923xxn2	149	1	Stimulator	Stimulator	NNP
cord-261532-q923xxn2	149	2	of	of	IN
cord-261532-q923xxn2	149	3	interferon	interferon	NN
cord-261532-q923xxn2	149	4	genes	gene	NNS
cord-261532-q923xxn2	149	5	STING	sting	VBP
cord-261532-q923xxn2	149	6	,	,	,
cord-261532-q923xxn2	149	7	also	also	RB
cord-261532-q923xxn2	149	8	named	name	VBN
cord-261532-q923xxn2	149	9	mediator	mediator	NN
cord-261532-q923xxn2	149	10	of	of	IN
cord-261532-q923xxn2	149	11	IRF3	IRF3	NNP
cord-261532-q923xxn2	149	12	activation	activation	NN
cord-261532-q923xxn2	149	13	(	(	-LRB-
cord-261532-q923xxn2	149	14	MITA)/endoplasmic	mita)/endoplasmic	JJ
cord-261532-q923xxn2	149	15	reticulum	reticulum	NN
cord-261532-q923xxn2	149	16	(	(	-LRB-
cord-261532-q923xxn2	149	17	ER	ER	NNP
cord-261532-q923xxn2	149	18	)	)	-RRB-
cord-261532-q923xxn2	150	1	interferon	interferon	NNP
cord-261532-q923xxn2	150	2	stimulator	stimulator	NNP
cord-261532-q923xxn2	150	3	(	(	-LRB-
cord-261532-q923xxn2	150	4	ERIS)/membrane	eris)/membrane	IN
cord-261532-q923xxn2	150	5	tetraspanner	tetraspanner	NN
cord-261532-q923xxn2	150	6	associated	associate	VBN
cord-261532-q923xxn2	150	7	with	with	IN
cord-261532-q923xxn2	150	8	MHC	MHC	NNP
cord-261532-q923xxn2	150	9	class	class	NN
cord-261532-q923xxn2	150	10	II	II	NNP
cord-261532-q923xxn2	150	11	(	(	-LRB-
cord-261532-q923xxn2	150	12	MPYS	MPYS	NNP
cord-261532-q923xxn2	150	13	)	)	-RRB-
cord-261532-q923xxn2	150	14	that	that	WDT
cord-261532-q923xxn2	150	15	locates	locate	VBZ
cord-261532-q923xxn2	150	16	to	to	IN
cord-261532-q923xxn2	150	17	ER	ER	NNP
cord-261532-q923xxn2	150	18	or	or	CC
cord-261532-q923xxn2	150	19	/	/	SYM
cord-261532-q923xxn2	150	20	and	and	CC
cord-261532-q923xxn2	150	21	mitochondria	mitochondrion	NNS
cord-261532-q923xxn2	150	22	,	,	,
cord-261532-q923xxn2	150	23	is	be	VBZ
cord-261532-q923xxn2	150	24	an	an	DT
cord-261532-q923xxn2	150	25	important	important	JJ
cord-261532-q923xxn2	150	26	adaptor	adaptor	NN
cord-261532-q923xxn2	150	27	with	with	IN
cord-261532-q923xxn2	150	28	a	a	DT
cord-261532-q923xxn2	150	29	potent	potent	JJ
cord-261532-q923xxn2	150	30	ability	ability	NN
cord-261532-q923xxn2	150	31	to	to	TO
cord-261532-q923xxn2	150	32	induce	induce	VB
cord-261532-q923xxn2	150	33	type	type	NN
cord-261532-q923xxn2	150	34	I	-PRON-	PRP
cord-261532-q923xxn2	150	35	interferons	interferon	NNS
cord-261532-q923xxn2	150	36	,	,	,
cord-261532-q923xxn2	150	37	interleukins	interleukin	NNS
cord-261532-q923xxn2	150	38	and	and	CC
cord-261532-q923xxn2	150	39	other	other	JJ
cord-261532-q923xxn2	150	40	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	150	41	factors	factor	NNS
cord-261532-q923xxn2	150	42	(	(	-LRB-
cord-261532-q923xxn2	150	43	Ishikawa	Ishikawa	NNP
cord-261532-q923xxn2	150	44	and	and	CC
cord-261532-q923xxn2	150	45	Barber	Barber	NNP
cord-261532-q923xxn2	150	46	,	,	,
cord-261532-q923xxn2	150	47	2008	2008	CD
cord-261532-q923xxn2	150	48	;	;	.
cord-261532-q923xxn2	151	1	Zhong	Zhong	NNP
cord-261532-q923xxn2	151	2	et	et	NNP
cord-261532-q923xxn2	151	3	al	al	NNP
cord-261532-q923xxn2	151	4	.	.	NNP
cord-261532-q923xxn2	151	5	,	,	,
cord-261532-q923xxn2	151	6	2008	2008	CD
cord-261532-q923xxn2	151	7	;	;	:
cord-261532-q923xxn2	151	8	Sun	Sun	NNP
cord-261532-q923xxn2	151	9	et	et	NNP
cord-261532-q923xxn2	151	10	al	al	NNP
cord-261532-q923xxn2	151	11	.	.	NNP
cord-261532-q923xxn2	151	12	,	,	,
cord-261532-q923xxn2	151	13	2009	2009	CD
cord-261532-q923xxn2	151	14	)	)	-RRB-
cord-261532-q923xxn2	151	15	.	.	.
cord-261532-q923xxn2	152	1	Homo	homo	JJ
cord-261532-q923xxn2	152	2	sapiens	sapiens	JJ
cord-261532-q923xxn2	152	3	STING	sting	NN
cord-261532-q923xxn2	152	4	consists	consist	VBZ
cord-261532-q923xxn2	152	5	of	of	IN
cord-261532-q923xxn2	152	6	379	379	CD
cord-261532-q923xxn2	152	7	amino	amino	JJ
cord-261532-q923xxn2	152	8	acids	acid	NNS
cord-261532-q923xxn2	152	9	,	,	,
cord-261532-q923xxn2	152	10	with	with	IN
cord-261532-q923xxn2	152	11	a	a	DT
cord-261532-q923xxn2	152	12	signal	signal	JJ
cord-261532-q923xxn2	152	13	peptide	peptide	NN
cord-261532-q923xxn2	152	14	and	and	CC
cord-261532-q923xxn2	152	15	four	four	CD
cord-261532-q923xxn2	152	16	transmembrane	transmembrane	NN
cord-261532-q923xxn2	152	17	domains	domain	NNS
cord-261532-q923xxn2	152	18	at	at	IN
cord-261532-q923xxn2	152	19	its	-PRON-	PRP$
cord-261532-q923xxn2	152	20	N	n	CD
cord-261532-q923xxn2	152	21	-	-	HYPH
cord-261532-q923xxn2	152	22	terminus	terminus	NN
cord-261532-q923xxn2	152	23	.	.	.
cord-261532-q923xxn2	153	1	In	in	IN
cord-261532-q923xxn2	153	2	the	the	DT
cord-261532-q923xxn2	153	3	vicinity	vicinity	NN
cord-261532-q923xxn2	153	4	of	of	IN
cord-261532-q923xxn2	153	5	these	these	DT
cord-261532-q923xxn2	153	6	domains	domain	NNS
cord-261532-q923xxn2	153	7	there	there	RB
cord-261532-q923xxn2	153	8	exist	exist	VBP
cord-261532-q923xxn2	153	9	two	two	CD
cord-261532-q923xxn2	153	10	ER	er	NN
cord-261532-q923xxn2	153	11	retention	retention	NN
cord-261532-q923xxn2	153	12	sequences	sequence	NNS
cord-261532-q923xxn2	153	13	,	,	,
cord-261532-q923xxn2	153	14	R	R	NNP
cord-261532-q923xxn2	153	15	76	76	CD
cord-261532-q923xxn2	153	16	IR	IR	NNP
cord-261532-q923xxn2	153	17	78	78	CD
cord-261532-q923xxn2	153	18	and	and	CC
cord-261532-q923xxn2	153	19	R	R	NNP
cord-261532-q923xxn2	153	20	178	178	CD
cord-261532-q923xxn2	153	21	YR	YR	NNP
cord-261532-q923xxn2	153	22	180	180	CD
cord-261532-q923xxn2	153	23	,	,	,
cord-261532-q923xxn2	153	24	which	which	WDT
cord-261532-q923xxn2	153	25	are	be	VBP
cord-261532-q923xxn2	153	26	essential	essential	JJ
cord-261532-q923xxn2	153	27	for	for	IN
cord-261532-q923xxn2	153	28	the	the	DT
cord-261532-q923xxn2	153	29	proper	proper	JJ
cord-261532-q923xxn2	153	30	localization	localization	NN
cord-261532-q923xxn2	153	31	and	and	CC
cord-261532-q923xxn2	153	32	stability	stability	NN
cord-261532-q923xxn2	153	33	of	of	IN
cord-261532-q923xxn2	153	34	STING	sting	NN
cord-261532-q923xxn2	154	1	(	(	-LRB-
cord-261532-q923xxn2	154	2	Sun	Sun	NNP
cord-261532-q923xxn2	154	3	et	et	NNP
cord-261532-q923xxn2	154	4	al	al	NNP
cord-261532-q923xxn2	154	5	.	.	NNP
cord-261532-q923xxn2	154	6	,	,	,
cord-261532-q923xxn2	154	7	2009	2009	CD
cord-261532-q923xxn2	154	8	)	)	-RRB-
cord-261532-q923xxn2	154	9	.	.	.
cord-261532-q923xxn2	155	1	STING	sting	NN
cord-261532-q923xxn2	155	2	-	-	HYPH
cord-261532-q923xxn2	155	3	deficient	deficient	JJ
cord-261532-q923xxn2	155	4	mice	mouse	NNS
cord-261532-q923xxn2	155	5	are	be	VBP
cord-261532-q923xxn2	155	6	highly	highly	RB
cord-261532-q923xxn2	155	7	sensitive	sensitive	JJ
cord-261532-q923xxn2	155	8	to	to	IN
cord-261532-q923xxn2	155	9	both	both	DT
cord-261532-q923xxn2	155	10	RNA	RNA	NNP
cord-261532-q923xxn2	155	11	viruses	virus	NNS
cord-261532-q923xxn2	155	12	,	,	,
cord-261532-q923xxn2	155	13	e.g.	e.g.	DT
cord-261532-q923xxn2	155	14	vesicular	vesicular	JJ
cord-261532-q923xxn2	155	15	stomatitis	stomatitis	NN
cord-261532-q923xxn2	155	16	virus	virus	NN
cord-261532-q923xxn2	155	17	(	(	-LRB-
cord-261532-q923xxn2	155	18	VSV	VSV	NNP
cord-261532-q923xxn2	155	19	)	)	-RRB-
cord-261532-q923xxn2	155	20	and	and	CC
cord-261532-q923xxn2	155	21	Sendai	Sendai	NNP
cord-261532-q923xxn2	155	22	virus	virus	NN
cord-261532-q923xxn2	155	23	(	(	-LRB-
cord-261532-q923xxn2	155	24	SeV	sev	NN
cord-261532-q923xxn2	155	25	)	)	-RRB-
cord-261532-q923xxn2	155	26	and	and	CC
cord-261532-q923xxn2	155	27	DNA	dna	NN
cord-261532-q923xxn2	155	28	viruses	virus	NNS
cord-261532-q923xxn2	155	29	,	,	.
cord-261532-q923xxn2	156	1	e.g.	e.g.	IN
cord-261532-q923xxn2	156	2	herpes	herpes	NNP
cord-261532-q923xxn2	156	3	simplex	simplex	NNP
cord-261532-q923xxn2	156	4	virus	virus	NN
cord-261532-q923xxn2	156	5	type	type	NN
cord-261532-q923xxn2	156	6	I	-PRON-	PRP
cord-261532-q923xxn2	156	7	(	(	-LRB-
cord-261532-q923xxn2	156	8	HSV-1	hsv-1	NN
cord-261532-q923xxn2	156	9	)	)	-RRB-
cord-261532-q923xxn2	156	10	,	,	,
cord-261532-q923xxn2	156	11	underscoring	underscore	VBG
cord-261532-q923xxn2	156	12	the	the	DT
cord-261532-q923xxn2	156	13	physiological	physiological	JJ
cord-261532-q923xxn2	156	14	function	function	NN
cord-261532-q923xxn2	156	15	of	of	IN
cord-261532-q923xxn2	156	16	STING	sting	NN
cord-261532-q923xxn2	156	17	in	in	IN
cord-261532-q923xxn2	156	18	antiviral	antiviral	JJ
cord-261532-q923xxn2	156	19	immune	immune	JJ
cord-261532-q923xxn2	156	20	responses	response	NNS
cord-261532-q923xxn2	156	21	(	(	-LRB-
cord-261532-q923xxn2	156	22	Ishikawa	Ishikawa	NNP
cord-261532-q923xxn2	156	23	et	et	NNP
cord-261532-q923xxn2	156	24	al	al	NNP
cord-261532-q923xxn2	156	25	.	.	NNP
cord-261532-q923xxn2	156	26	,	,	,
cord-261532-q923xxn2	156	27	2009	2009	CD
cord-261532-q923xxn2	156	28	)	)	-RRB-
cord-261532-q923xxn2	156	29	.	.	.
cord-261532-q923xxn2	157	1	However	however	RB
cord-261532-q923xxn2	157	2	,	,	,
cord-261532-q923xxn2	157	3	STING	STING	NNP
cord-261532-q923xxn2	157	4	can	can	MD
cord-261532-q923xxn2	157	5	not	not	RB
cord-261532-q923xxn2	157	6	bind	bind	VB
cord-261532-q923xxn2	157	7	directly	directly	RB
cord-261532-q923xxn2	157	8	to	to	IN
cord-261532-q923xxn2	157	9	RNA	RNA	NNP
cord-261532-q923xxn2	157	10	or	or	CC
cord-261532-q923xxn2	157	11	DNA	DNA	NNP
cord-261532-q923xxn2	157	12	(	(	-LRB-
cord-261532-q923xxn2	157	13	Barber	Barber	NNP
cord-261532-q923xxn2	157	14	,	,	,
cord-261532-q923xxn2	157	15	2011	2011	CD
cord-261532-q923xxn2	157	16	)	)	-RRB-
cord-261532-q923xxn2	157	17	.	.	.
cord-261532-q923xxn2	158	1	In	in	IN
cord-261532-q923xxn2	158	2	RNA	RNA	NNP
cord-261532-q923xxn2	158	3	-	-	HYPH
cord-261532-q923xxn2	158	4	triggered	trigger	VBN
cord-261532-q923xxn2	158	5	pathway	pathway	NN
cord-261532-q923xxn2	158	6	,	,	,
cord-261532-q923xxn2	158	7	STING	STING	NNP
cord-261532-q923xxn2	158	8	is	be	VBZ
cord-261532-q923xxn2	158	9	mainly	mainly	RB
cord-261532-q923xxn2	158	10	involved	involve	VBN
cord-261532-q923xxn2	158	11	in	in	IN
cord-261532-q923xxn2	158	12	RIG	rig	NN
cord-261532-q923xxn2	158	13	-	-	:
cord-261532-q923xxn2	158	14	I	-PRON-	PRP
cord-261532-q923xxn2	158	15	rather	rather	RB
cord-261532-q923xxn2	158	16	than	than	IN
cord-261532-q923xxn2	158	17	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	158	18	signaling	signal	VBG
cord-261532-q923xxn2	158	19	.	.	.
cord-261532-q923xxn2	159	1	Our	-PRON-	PRP$
cord-261532-q923xxn2	159	2	published	publish	VBN
cord-261532-q923xxn2	159	3	data	datum	NNS
cord-261532-q923xxn2	159	4	show	show	NN
cord-261532-q923xxn2	159	5	that	that	IN
cord-261532-q923xxn2	159	6	STING	sting	NN
cord-261532-q923xxn2	159	7	interacts	interact	VBZ
cord-261532-q923xxn2	159	8	with	with	IN
cord-261532-q923xxn2	159	9	RIG-	RIG-	NNP
cord-261532-q923xxn2	160	1	I	-PRON-	PRP
cord-261532-q923xxn2	160	2	but	but	CC
cord-261532-q923xxn2	160	3	not	not	RB
cord-261532-q923xxn2	160	4	Mda-5	Mda-5	NNP
cord-261532-q923xxn2	160	5	,	,	,
cord-261532-q923xxn2	160	6	consistent	consistent	JJ
cord-261532-q923xxn2	160	7	with	with	IN
cord-261532-q923xxn2	160	8	the	the	DT
cord-261532-q923xxn2	160	9	fact	fact	NN
cord-261532-q923xxn2	160	10	that	that	IN
cord-261532-q923xxn2	160	11	STING	sting	NN
cord-261532-q923xxn2	160	12	-	-	HYPH
cord-261532-q923xxn2	160	13	deficiency	deficiency	NN
cord-261532-q923xxn2	160	14	seldom	seldom	RB
cord-261532-q923xxn2	160	15	affects	affect	VBZ
cord-261532-q923xxn2	160	16	poly	poly	NNP
cord-261532-q923xxn2	160	17	(	(	-LRB-
cord-261532-q923xxn2	160	18	I	i	NN
cord-261532-q923xxn2	160	19	:	:	:
cord-261532-q923xxn2	160	20	C	C	NNP
cord-261532-q923xxn2	160	21	)	)	-RRB-
cord-261532-q923xxn2	160	22	(	(	-LRB-
cord-261532-q923xxn2	160	23	recognized	recognize	VBN
cord-261532-q923xxn2	160	24	by	by	IN
cord-261532-q923xxn2	160	25	Mda-5)-mediated	Mda-5)-mediated	NNP
cord-261532-q923xxn2	160	26	signaling	signal	VBG
cord-261532-q923xxn2	160	27	(	(	-LRB-
cord-261532-q923xxn2	160	28	Ishikawa	Ishikawa	NNP
cord-261532-q923xxn2	160	29	et	et	NNP
cord-261532-q923xxn2	160	30	al	al	NNP
cord-261532-q923xxn2	160	31	.	.	NNP
cord-261532-q923xxn2	160	32	,	,	,
cord-261532-q923xxn2	160	33	2009	2009	CD
cord-261532-q923xxn2	160	34	)	)	-RRB-
cord-261532-q923xxn2	160	35	.	.	.
cord-261532-q923xxn2	161	1	On	on	IN
cord-261532-q923xxn2	161	2	the	the	DT
cord-261532-q923xxn2	161	3	other	other	JJ
cord-261532-q923xxn2	161	4	hand	hand	NN
cord-261532-q923xxn2	161	5	,	,	,
cord-261532-q923xxn2	161	6	besides	besides	IN
cord-261532-q923xxn2	161	7	IFI16	ifi16	NN
cord-261532-q923xxn2	161	8	and	and	CC
cord-261532-q923xxn2	161	9	DDX41	ddx41	VB
cord-261532-q923xxn2	161	10	,	,	,
cord-261532-q923xxn2	161	11	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	161	12	DNA	DNA	NNP
cord-261532-q923xxn2	161	13	sensor(s	sensor(s	NNP
cord-261532-q923xxn2	161	14	)	)	-RRB-
cord-261532-q923xxn2	161	15	that	that	WDT
cord-261532-q923xxn2	161	16	utilize	utilize	VBP
cord-261532-q923xxn2	161	17	STING	sting	NN
cord-261532-q923xxn2	161	18	for	for	IN
cord-261532-q923xxn2	161	19	the	the	DT
cord-261532-q923xxn2	161	20	induction	induction	NN
cord-261532-q923xxn2	161	21	of	of	IN
cord-261532-q923xxn2	161	22	type	type	NN
cord-261532-q923xxn2	161	23	I	-PRON-	PRP
cord-261532-q923xxn2	161	24	interferons	interferon	NNS
cord-261532-q923xxn2	161	25	remain	remain	VBP
cord-261532-q923xxn2	161	26	to	to	TO
cord-261532-q923xxn2	161	27	be	be	VB
cord-261532-q923xxn2	161	28	identified	identify	VBN
cord-261532-q923xxn2	161	29	or	or	CC
cord-261532-q923xxn2	161	30	validated	validate	VBN
cord-261532-q923xxn2	161	31	.	.	.
cord-261532-q923xxn2	162	1	Intracellular	Intracellular	NNP
cord-261532-q923xxn2	162	2	localization	localization	NN
cord-261532-q923xxn2	162	3	is	be	VBZ
cord-261532-q923xxn2	162	4	a	a	DT
cord-261532-q923xxn2	162	5	primary	primary	JJ
cord-261532-q923xxn2	162	6	factor	factor	NN
cord-261532-q923xxn2	162	7	for	for	IN
cord-261532-q923xxn2	162	8	the	the	DT
cord-261532-q923xxn2	162	9	function	function	NN
cord-261532-q923xxn2	162	10	of	of	IN
cord-261532-q923xxn2	162	11	STING	sting	NN
cord-261532-q923xxn2	162	12	,	,	,
cord-261532-q923xxn2	162	13	since	since	IN
cord-261532-q923xxn2	162	14	it	-PRON-	PRP
cord-261532-q923xxn2	162	15	is	be	VBZ
cord-261532-q923xxn2	162	16	transported	transport	VBN
cord-261532-q923xxn2	162	17	into	into	IN
cord-261532-q923xxn2	162	18	ER	ER	NNP
cord-261532-q923xxn2	162	19	lumen	lumen	NN
cord-261532-q923xxn2	162	20	from	from	IN
cord-261532-q923xxn2	162	21	ER	er	NN
cord-261532-q923xxn2	162	22	-	-	HYPH
cord-261532-q923xxn2	162	23	bond	bond	NN
cord-261532-q923xxn2	162	24	ribosomes	ribosome	NNS
cord-261532-q923xxn2	162	25	after	after	IN
cord-261532-q923xxn2	162	26	translation	translation	NN
cord-261532-q923xxn2	162	27	,	,	,
cord-261532-q923xxn2	162	28	depending	depend	VBG
cord-261532-q923xxn2	162	29	on	on	IN
cord-261532-q923xxn2	162	30	the	the	DT
cord-261532-q923xxn2	162	31	interaction	interaction	NN
cord-261532-q923xxn2	162	32	between	between	IN
cord-261532-q923xxn2	162	33	STING	sting	NN
cord-261532-q923xxn2	162	34	and	and	CC
cord-261532-q923xxn2	162	35	a	a	DT
cord-261532-q923xxn2	162	36	four	four	CD
cord-261532-q923xxn2	162	37	-	-	HYPH
cord-261532-q923xxn2	162	38	subnuit	subnuit	NN
cord-261532-q923xxn2	162	39	(	(	-LRB-
cord-261532-q923xxn2	162	40	α	α	NN
cord-261532-q923xxn2	162	41	-	-	HYPH
cord-261532-q923xxn2	162	42	Δ	Δ	NNP
cord-261532-q923xxn2	162	43	)	)	-RRB-
cord-261532-q923xxn2	162	44	complex	complex	NN
cord-261532-q923xxn2	162	45	,	,	,
cord-261532-q923xxn2	162	46	the	the	DT
cord-261532-q923xxn2	162	47	translocon	translocon	NNP
cord-261532-q923xxn2	162	48	associated	associate	VBD
cord-261532-q923xxn2	162	49	protein	protein	NN
cord-261532-q923xxn2	162	50	(	(	-LRB-
cord-261532-q923xxn2	162	51	TRAP	trap	NN
cord-261532-q923xxn2	162	52	)	)	-RRB-
cord-261532-q923xxn2	162	53	complex	complex	JJ
cord-261532-q923xxn2	162	54	SSR2	SSR2	NNP
cord-261532-q923xxn2	162	55	/	/	SYM
cord-261532-q923xxn2	162	56	TRAPβ	TRAPβ	NNP
cord-261532-q923xxn2	162	57	.	.	.
cord-261532-q923xxn2	163	1	Individually	individually	RB
cord-261532-q923xxn2	163	2	,	,	,
cord-261532-q923xxn2	163	3	the	the	DT
cord-261532-q923xxn2	163	4	TRAP	trap	NN
cord-261532-q923xxn2	163	5	complex	complex	NN
cord-261532-q923xxn2	163	6	can	can	MD
cord-261532-q923xxn2	163	7	bind	bind	VB
cord-261532-q923xxn2	163	8	with	with	IN
cord-261532-q923xxn2	163	9	translocons	translocon	NNS
cord-261532-q923xxn2	163	10	,	,	,
cord-261532-q923xxn2	163	11	a	a	DT
cord-261532-q923xxn2	163	12	three	three	CD
cord-261532-q923xxn2	163	13	-	-	HYPH
cord-261532-q923xxn2	163	14	subunit	subunit	NN
cord-261532-q923xxn2	163	15	component	component	NN
cord-261532-q923xxn2	163	16	comprising	comprise	VBG
cord-261532-q923xxn2	163	17	SEC61α	SEC61α	NNP
cord-261532-q923xxn2	163	18	/	/	SYM
cord-261532-q923xxn2	163	19	SEC61β/	SEC61β/	NNP
cord-261532-q923xxn2	163	20	SEC61γ	SEC61γ	NNP
cord-261532-q923xxn2	163	21	required	require	VBD
cord-261532-q923xxn2	163	22	for	for	IN
cord-261532-q923xxn2	163	23	protein	protein	NN
cord-261532-q923xxn2	163	24	folding	folding	NN
cord-261532-q923xxn2	163	25	and	and	CC
cord-261532-q923xxn2	163	26	secretion	secretion	NN
cord-261532-q923xxn2	163	27	.	.	.
cord-261532-q923xxn2	164	1	As	as	IN
cord-261532-q923xxn2	164	2	part	part	NN
cord-261532-q923xxn2	164	3	of	of	IN
cord-261532-q923xxn2	164	4	the	the	DT
cord-261532-q923xxn2	164	5	exocyst	exocyst	NN
cord-261532-q923xxn2	164	6	component	component	NN
cord-261532-q923xxn2	164	7	,	,	,
cord-261532-q923xxn2	164	8	Sec5	Sec5	NNP
cord-261532-q923xxn2	164	9	is	be	VBZ
cord-261532-q923xxn2	164	10	found	find	VBN
cord-261532-q923xxn2	164	11	to	to	IN
cord-261532-q923xxn2	164	12	colocalize	colocalize	VB
cord-261532-q923xxn2	164	13	with	with	IN
cord-261532-q923xxn2	164	14	STING	sting	NN
cord-261532-q923xxn2	164	15	,	,	,
cord-261532-q923xxn2	164	16	essential	essential	JJ
cord-261532-q923xxn2	164	17	for	for	IN
cord-261532-q923xxn2	164	18	its	-PRON-	PRP$
cord-261532-q923xxn2	164	19	transportation	transportation	NN
cord-261532-q923xxn2	164	20	from	from	IN
cord-261532-q923xxn2	164	21	post	post	JJ
cord-261532-q923xxn2	164	22	-	-	JJ
cord-261532-q923xxn2	164	23	Golgi	golgi	NN
cord-261532-q923xxn2	164	24	to	to	IN
cord-261532-q923xxn2	164	25	plasma	plasma	NN
cord-261532-q923xxn2	164	26	membrane	membrane	NN
cord-261532-q923xxn2	164	27	.	.	.
cord-261532-q923xxn2	165	1	In	in	IN
cord-261532-q923xxn2	165	2	virus	virus	NN
cord-261532-q923xxn2	165	3	-	-	HYPH
cord-261532-q923xxn2	165	4	infected	infect	VBN
cord-261532-q923xxn2	165	5	cells	cell	NNS
cord-261532-q923xxn2	165	6	,	,	,
cord-261532-q923xxn2	165	7	STING	sting	VB
cord-261532-q923xxn2	165	8	translocates	translocate	NNS
cord-261532-q923xxn2	165	9	from	from	IN
cord-261532-q923xxn2	165	10	ER	ER	NNP
cord-261532-q923xxn2	165	11	to	to	IN
cord-261532-q923xxn2	165	12	Golgi	Golgi	NNP
cord-261532-q923xxn2	165	13	,	,	,
cord-261532-q923xxn2	165	14	and	and	CC
cord-261532-q923xxn2	165	15	then	then	RB
cord-261532-q923xxn2	165	16	to	to	IN
cord-261532-q923xxn2	165	17	cytoplasmic	cytoplasmic	JJ
cord-261532-q923xxn2	165	18	punctate	punctate	NN
cord-261532-q923xxn2	165	19	structures	structure	NNS
cord-261532-q923xxn2	165	20	,	,	,
cord-261532-q923xxn2	165	21	where	where	WRB
cord-261532-q923xxn2	165	22	it	-PRON-	PRP
cord-261532-q923xxn2	165	23	recruits	recruit	VBZ
cord-261532-q923xxn2	165	24	TBK1	TBK1	NNP
cord-261532-q923xxn2	165	25	in	in	IN
cord-261532-q923xxn2	165	26	the	the	DT
cord-261532-q923xxn2	165	27	aid	aid	NN
cord-261532-q923xxn2	165	28	of	of	IN
cord-261532-q923xxn2	165	29	RalB	RalB	NNP
cord-261532-q923xxn2	165	30	GTPase	GTPase	NNP
cord-261532-q923xxn2	165	31	and	and	CC
cord-261532-q923xxn2	165	32	Sec5	Sec5	NNP
cord-261532-q923xxn2	165	33	.	.	.
cord-261532-q923xxn2	166	1	IRF3	IRF3	NNP
cord-261532-q923xxn2	166	2	/	/	SYM
cord-261532-q923xxn2	166	3	IRF7	IRF7	NNP
cord-261532-q923xxn2	166	4	is	be	VBZ
cord-261532-q923xxn2	166	5	thus	thus	RB
cord-261532-q923xxn2	166	6	activated	activate	VBN
cord-261532-q923xxn2	166	7	to	to	TO
cord-261532-q923xxn2	166	8	induce	induce	VB
cord-261532-q923xxn2	166	9	the	the	DT
cord-261532-q923xxn2	166	10	expression	expression	NN
cord-261532-q923xxn2	166	11	of	of	IN
cord-261532-q923xxn2	166	12	type	type	NN
cord-261532-q923xxn2	166	13	I	-PRON-	PRP
cord-261532-q923xxn2	166	14	interferons	interferon	NNS
cord-261532-q923xxn2	166	15	.	.	.
cord-261532-q923xxn2	167	1	Importantly	importantly	RB
cord-261532-q923xxn2	167	2	,	,	,
cord-261532-q923xxn2	167	3	STAT6	STAT6	NNP
cord-261532-q923xxn2	167	4	is	be	VBZ
cord-261532-q923xxn2	167	5	also	also	RB
cord-261532-q923xxn2	167	6	activated	activate	VBN
cord-261532-q923xxn2	167	7	to	to	TO
cord-261532-q923xxn2	167	8	trigger	trigger	VB
cord-261532-q923xxn2	167	9	the	the	DT
cord-261532-q923xxn2	167	10	production	production	NN
cord-261532-q923xxn2	167	11	of	of	IN
cord-261532-q923xxn2	167	12	chemokines	chemokine	NNS
cord-261532-q923xxn2	167	13	,	,	,
cord-261532-q923xxn2	167	14	which	which	WDT
cord-261532-q923xxn2	167	15	is	be	VBZ
cord-261532-q923xxn2	167	16	discussed	discuss	VBN
cord-261532-q923xxn2	167	17	in	in	IN
cord-261532-q923xxn2	167	18	details	detail	NNS
cord-261532-q923xxn2	167	19	later	later	RB
cord-261532-q923xxn2	167	20	(	(	-LRB-
cord-261532-q923xxn2	167	21	Fig	Fig	NNP
cord-261532-q923xxn2	167	22	.	.	.
cord-261532-q923xxn2	167	23	3	3	CD
cord-261532-q923xxn2	167	24	)	)	-RRB-
cord-261532-q923xxn2	167	25	.	.	.
cord-261532-q923xxn2	168	1	The	the	DT
cord-261532-q923xxn2	168	2	regulation	regulation	NN
cord-261532-q923xxn2	168	3	of	of	IN
cord-261532-q923xxn2	168	4	STING	sting	NN
cord-261532-q923xxn2	168	5	turns	turn	VBZ
cord-261532-q923xxn2	168	6	out	out	RP
cord-261532-q923xxn2	168	7	very	very	RB
cord-261532-q923xxn2	168	8	complicated	complicated	JJ
cord-261532-q923xxn2	168	9	.	.	.
cord-261532-q923xxn2	169	1	STING	STING	NNP
cord-261532-q923xxn2	169	2	can	can	MD
cord-261532-q923xxn2	169	3	be	be	VB
cord-261532-q923xxn2	169	4	ubiquitinated	ubiquitinate	VBN
cord-261532-q923xxn2	169	5	and	and	CC
cord-261532-q923xxn2	169	6	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	169	7	,	,	,
cord-261532-q923xxn2	169	8	and	and	CC
cord-261532-q923xxn2	169	9	under	under	IN
cord-261532-q923xxn2	169	10	the	the	DT
cord-261532-q923xxn2	169	11	stimulation	stimulation	NN
cord-261532-q923xxn2	169	12	of	of	IN
cord-261532-q923xxn2	169	13	SeV	SeV	NNS
cord-261532-q923xxn2	169	14	or	or	CC
cord-261532-q923xxn2	169	15	poly	poly	JJ
cord-261532-q923xxn2	169	16	(	(	-LRB-
cord-261532-q923xxn2	169	17	I	i	NN
cord-261532-q923xxn2	169	18	:	:	:
cord-261532-q923xxn2	169	19	C)/poly	C)/poly	NNP
cord-261532-q923xxn2	169	20	dAdT	dadt	ADD
cord-261532-q923xxn2	169	21	,	,	,
cord-261532-q923xxn2	169	22	STING	sting	NN
cord-261532-q923xxn2	169	23	undergoes	undergo	VBZ
cord-261532-q923xxn2	169	24	apparent	apparent	JJ
cord-261532-q923xxn2	169	25	oligomerization	oligomerization	NN
cord-261532-q923xxn2	169	26	(	(	-LRB-
cord-261532-q923xxn2	169	27	Sun	Sun	NNP
cord-261532-q923xxn2	169	28	et	et	FW
cord-261532-q923xxn2	169	29	al	al	NNP
cord-261532-q923xxn2	169	30	.	.	NNP
cord-261532-q923xxn2	169	31	,	,	,
cord-261532-q923xxn2	169	32	2009	2009	CD
cord-261532-q923xxn2	169	33	)	)	-RRB-
cord-261532-q923xxn2	169	34	.	.	.
cord-261532-q923xxn2	170	1	And	and	CC
cord-261532-q923xxn2	170	2	in	in	IN
cord-261532-q923xxn2	170	3	vitro	vitro	FW
cord-261532-q923xxn2	170	4	,	,	,
cord-261532-q923xxn2	170	5	STING	STING	NNP
cord-261532-q923xxn2	170	6	interacts	interact	VBZ
cord-261532-q923xxn2	170	7	with	with	IN
cord-261532-q923xxn2	170	8	TBK1	TBK1	NNP
cord-261532-q923xxn2	170	9	and	and	CC
cord-261532-q923xxn2	170	10	IRF3	IRF3	NNP
cord-261532-q923xxn2	170	11	,	,	,
cord-261532-q923xxn2	170	12	and	and	CC
cord-261532-q923xxn2	170	13	stimulates	stimulate	VBZ
cord-261532-q923xxn2	170	14	the	the	DT
cord-261532-q923xxn2	170	15	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	170	16	of	of	IN
cord-261532-q923xxn2	170	17	IRF3	IRF3	NNP
cord-261532-q923xxn2	170	18	by	by	IN
cord-261532-q923xxn2	170	19	TBK1	TBK1	NNP
cord-261532-q923xxn2	170	20	in	in	IN
cord-261532-q923xxn2	170	21	the	the	DT
cord-261532-q923xxn2	170	22	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	170	23	DNA	dna	NN
cord-261532-q923xxn2	170	24	signaling	signal	VBG
cord-261532-q923xxn2	170	25	pathway	pathway	NN
cord-261532-q923xxn2	170	26	(	(	-LRB-
cord-261532-q923xxn2	170	27	Tanaka	Tanaka	NNP
cord-261532-q923xxn2	170	28	and	and	CC
cord-261532-q923xxn2	170	29	Chen	Chen	NNP
cord-261532-q923xxn2	170	30	,	,	,
cord-261532-q923xxn2	170	31	2012	2012	CD
cord-261532-q923xxn2	170	32	)	)	-RRB-
cord-261532-q923xxn2	170	33	.	.	.
cord-261532-q923xxn2	171	1	A	a	DT
cord-261532-q923xxn2	171	2	research	research	NN
cord-261532-q923xxn2	171	3	claims	claim	VBZ
cord-261532-q923xxn2	171	4	that	that	IN
cord-261532-q923xxn2	171	5	there	there	EX
cord-261532-q923xxn2	171	6	is	be	VBZ
cord-261532-q923xxn2	171	7	colocalization	colocalization	NN
cord-261532-q923xxn2	171	8	between	between	IN
cord-261532-q923xxn2	171	9	autophagy	autophagy	NN
cord-261532-q923xxn2	171	10	-	-	HYPH
cord-261532-q923xxn2	171	11	related	relate	VBN
cord-261532-q923xxn2	171	12	gene	gene	NN
cord-261532-q923xxn2	171	13	9a	9a	NN
cord-261532-q923xxn2	171	14	(	(	-LRB-
cord-261532-q923xxn2	171	15	ATG9a	atg9a	NN
cord-261532-q923xxn2	171	16	)	)	-RRB-
cord-261532-q923xxn2	171	17	and	and	CC
cord-261532-q923xxn2	171	18	STING	sting	VB
cord-261532-q923xxn2	171	19	that	that	WDT
cord-261532-q923xxn2	171	20	negatively	negatively	RB
cord-261532-q923xxn2	171	21	regulates	regulate	VBZ
cord-261532-q923xxn2	171	22	STING	sting	NN
cord-261532-q923xxn2	171	23	signaling	signaling	NN
cord-261532-q923xxn2	171	24	.	.	.
cord-261532-q923xxn2	172	1	In	in	IN
cord-261532-q923xxn2	172	2	addition	addition	NN
cord-261532-q923xxn2	172	3	,	,	,
cord-261532-q923xxn2	172	4	3	3	CD
cord-261532-q923xxn2	172	5	'	'	POS
cord-261532-q923xxn2	172	6	repairing	repair	VBG
cord-261532-q923xxn2	172	7	exonuclease	exonuclease	NN
cord-261532-q923xxn2	172	8	1	1	CD
cord-261532-q923xxn2	173	1	(	(	-LRB-
cord-261532-q923xxn2	173	2	Trex1	Trex1	NNP
cord-261532-q923xxn2	173	3	)	)	-RRB-
cord-261532-q923xxn2	173	4	plausibly	plausibly	RB
cord-261532-q923xxn2	173	5	downregulates	downregulate	VBZ
cord-261532-q923xxn2	173	6	STING	sting	NN
cord-261532-q923xxn2	173	7	-	-	HYPH
cord-261532-q923xxn2	173	8	mediated	mediate	VBN
cord-261532-q923xxn2	173	9	signal	signal	NN
cord-261532-q923xxn2	173	10	pathways	pathway	NNS
cord-261532-q923xxn2	173	11	,	,	,
cord-261532-q923xxn2	173	12	for	for	IN
cord-261532-q923xxn2	174	1	reverse	reverse	VB
cord-261532-q923xxn2	174	2	transcribed	transcribe	VBN
cord-261532-q923xxn2	174	3	human	human	JJ
cord-261532-q923xxn2	174	4	immunodeficiency	immunodeficiency	NN
cord-261532-q923xxn2	174	5	virus	virus	NN
cord-261532-q923xxn2	174	6	type	type	NN
cord-261532-q923xxn2	174	7	I	-PRON-	PRP
cord-261532-q923xxn2	174	8	(	(	-LRB-
cord-261532-q923xxn2	174	9	HIV-1	HIV-1	NNP
cord-261532-q923xxn2	174	10	)	)	-RRB-
cord-261532-q923xxn2	174	11	DNA	DNA	NNP
cord-261532-q923xxn2	174	12	activates	activate	VBZ
cord-261532-q923xxn2	174	13	STING	sting	NN
cord-261532-q923xxn2	174	14	to	to	TO
cord-261532-q923xxn2	174	15	suppress	suppress	VB
cord-261532-q923xxn2	174	16	its	-PRON-	PRP$
cord-261532-q923xxn2	174	17	own	own	JJ
cord-261532-q923xxn2	174	18	replication	replication	NN
cord-261532-q923xxn2	174	19	or	or	CC
cord-261532-q923xxn2	174	20	to	to	TO
cord-261532-q923xxn2	174	21	eliminate	eliminate	VB
cord-261532-q923xxn2	174	22	other	other	JJ
cord-261532-q923xxn2	174	23	DNA	dna	NN
cord-261532-q923xxn2	174	24	viruses	virus	NNS
cord-261532-q923xxn2	174	25	(	(	-LRB-
cord-261532-q923xxn2	174	26	Yan	Yan	NNP
cord-261532-q923xxn2	174	27	et	et	NNP
cord-261532-q923xxn2	174	28	al	al	NNP
cord-261532-q923xxn2	174	29	.	.	NNP
cord-261532-q923xxn2	174	30	,	,	,
cord-261532-q923xxn2	174	31	2011	2011	CD
cord-261532-q923xxn2	174	32	)	)	-RRB-
cord-261532-q923xxn2	174	33	.	.	.
cord-261532-q923xxn2	175	1	Interestingly	interestingly	RB
cord-261532-q923xxn2	175	2	,	,	,
cord-261532-q923xxn2	175	3	STING	STING	NNP
cord-261532-q923xxn2	175	4	is	be	VBZ
cord-261532-q923xxn2	175	5	found	find	VBN
cord-261532-q923xxn2	175	6	to	to	TO
cord-261532-q923xxn2	175	7	share	share	VB
cord-261532-q923xxn2	175	8	homology	homology	NN
cord-261532-q923xxn2	175	9	with	with	IN
cord-261532-q923xxn2	175	10	proteins	protein	NNS
cord-261532-q923xxn2	175	11	of	of	IN
cord-261532-q923xxn2	175	12	Flavivirus	Flavivirus	NNP
cord-261532-q923xxn2	175	13	,	,	,
cord-261532-q923xxn2	175	14	such	such	JJ
cord-261532-q923xxn2	175	15	as	as	IN
cord-261532-q923xxn2	175	16	dengue	dengue	NN
cord-261532-q923xxn2	175	17	virus	virus	NN
cord-261532-q923xxn2	175	18	,	,	,
cord-261532-q923xxn2	175	19	yellow	yellow	JJ
cord-261532-q923xxn2	175	20	fever	fever	NN
cord-261532-q923xxn2	175	21	virus	virus	NN
cord-261532-q923xxn2	175	22	and	and	CC
cord-261532-q923xxn2	175	23	Hepatitis	Hepatitis	NNP
cord-261532-q923xxn2	175	24	C	C	NNP
cord-261532-q923xxn2	175	25	virus	virus	NN
cord-261532-q923xxn2	175	26	,	,	,
cord-261532-q923xxn2	175	27	all	all	DT
cord-261532-q923xxn2	175	28	of	of	IN
cord-261532-q923xxn2	175	29	which	which	WDT
cord-261532-q923xxn2	175	30	localize	localize	VBP
cord-261532-q923xxn2	175	31	to	to	IN
cord-261532-q923xxn2	175	32	ER	ER	NNP
cord-261532-q923xxn2	175	33	(	(	-LRB-
cord-261532-q923xxn2	175	34	Ishikawa	Ishikawa	NNP
cord-261532-q923xxn2	175	35	et	et	NNP
cord-261532-q923xxn2	175	36	al	al	NNP
cord-261532-q923xxn2	175	37	.	.	NNP
cord-261532-q923xxn2	175	38	,	,	,
cord-261532-q923xxn2	175	39	2009	2009	CD
cord-261532-q923xxn2	175	40	)	)	-RRB-
cord-261532-q923xxn2	175	41	.	.	.
cord-261532-q923xxn2	176	1	Current	current	JJ
cord-261532-q923xxn2	176	2	evidence	evidence	NN
cord-261532-q923xxn2	176	3	shows	show	VBZ
cord-261532-q923xxn2	176	4	that	that	IN
cord-261532-q923xxn2	176	5	human	human	JJ
cord-261532-q923xxn2	176	6	coronavirus	coronavirus	NN
cord-261532-q923xxn2	176	7	(	(	-LRB-
cord-261532-q923xxn2	176	8	HcoV	HcoV	NNP
cord-261532-q923xxn2	176	9	)	)	-RRB-
cord-261532-q923xxn2	177	1	NL63	nl63	JJ
cord-261532-q923xxn2	177	2	and	and	CC
cord-261532-q923xxn2	177	3	severe	severe	JJ
cord-261532-q923xxn2	177	4	acute	acute	JJ
cord-261532-q923xxn2	177	5	respiratory	respiratory	JJ
cord-261532-q923xxn2	177	6	syndrome	syndrome	NN
cord-261532-q923xxn2	178	1	(	(	-LRB-
cord-261532-q923xxn2	178	2	SARS	SARS	NNP
cord-261532-q923xxn2	178	3	)	)	-RRB-
cord-261532-q923xxn2	178	4	CoV	CoV	NNP
cord-261532-q923xxn2	178	5	papain	papain	NN
cord-261532-q923xxn2	178	6	-	-	HYPH
cord-261532-q923xxn2	178	7	like	like	JJ
cord-261532-q923xxn2	178	8	protease	protease	NN
cord-261532-q923xxn2	178	9	(	(	-LRB-
cord-261532-q923xxn2	178	10	PLP	PLP	NNP
cord-261532-q923xxn2	178	11	)	)	-RRB-
cord-261532-q923xxn2	178	12	interact	interact	VBP
cord-261532-q923xxn2	178	13	with	with	IN
cord-261532-q923xxn2	178	14	STING	sting	NN
cord-261532-q923xxn2	178	15	to	to	TO
cord-261532-q923xxn2	178	16	negatively	negatively	RB
cord-261532-q923xxn2	178	17	regulate	regulate	VB
cord-261532-q923xxn2	178	18	signaling	signal	VBG
cord-261532-q923xxn2	178	19	by	by	IN
cord-261532-q923xxn2	178	20	disrupting	disrupt	VBG
cord-261532-q923xxn2	178	21	the	the	DT
cord-261532-q923xxn2	178	22	STING	sting	NN
cord-261532-q923xxn2	178	23	dimmers	dimmer	NNS
cord-261532-q923xxn2	178	24	and	and	CC
cord-261532-q923xxn2	178	25	preventing	prevent	VBG
cord-261532-q923xxn2	178	26	the	the	DT
cord-261532-q923xxn2	178	27	ubiquitination	ubiquitination	NN
cord-261532-q923xxn2	178	28	of	of	IN
cord-261532-q923xxn2	178	29	RIG	rig	NN
cord-261532-q923xxn2	178	30	-	-	:
cord-261532-q923xxn2	178	31	I	I	NNP
cord-261532-q923xxn2	178	32	/	/	SYM
cord-261532-q923xxn2	178	33	TBK1	TBK1	NNP
cord-261532-q923xxn2	178	34	/	/	SYM
cord-261532-q923xxn2	178	35	IRF3	IRF3	NNP
cord-261532-q923xxn2	178	36	(	(	-LRB-
cord-261532-q923xxn2	178	37	Sun	Sun	NNP
cord-261532-q923xxn2	178	38	et	et	FW
cord-261532-q923xxn2	178	39	al	al	NNP
cord-261532-q923xxn2	178	40	.	.	NNP
cord-261532-q923xxn2	178	41	,	,	,
cord-261532-q923xxn2	178	42	2012	2012	CD
cord-261532-q923xxn2	178	43	)	)	-RRB-
cord-261532-q923xxn2	178	44	.	.	.
cord-261532-q923xxn2	179	1	It	-PRON-	PRP
cord-261532-q923xxn2	179	2	is	be	VBZ
cord-261532-q923xxn2	179	3	yet	yet	RB
cord-261532-q923xxn2	179	4	-	-	HYPH
cord-261532-q923xxn2	179	5	to	to	TO
cord-261532-q923xxn2	179	6	-	-	HYPH
cord-261532-q923xxn2	179	7	be	be	VB
cord-261532-q923xxn2	179	8	validated	validate	VBN
cord-261532-q923xxn2	179	9	if	if	IN
cord-261532-q923xxn2	179	10	there	there	EX
cord-261532-q923xxn2	179	11	are	be	VBP
cord-261532-q923xxn2	179	12	other	other	JJ
cord-261532-q923xxn2	179	13	viruses	virus	NNS
cord-261532-q923xxn2	179	14	that	that	WDT
cord-261532-q923xxn2	179	15	inhibit	inhibit	VBP
cord-261532-q923xxn2	179	16	this	this	DT
cord-261532-q923xxn2	179	17	pathway	pathway	NN
cord-261532-q923xxn2	179	18	to	to	TO
cord-261532-q923xxn2	179	19	escape	escape	VB
cord-261532-q923xxn2	179	20	the	the	DT
cord-261532-q923xxn2	179	21	host	host	NN
cord-261532-q923xxn2	179	22	immune	immune	JJ
cord-261532-q923xxn2	179	23	responses	response	NNS
cord-261532-q923xxn2	179	24	.	.	.
cord-261532-q923xxn2	180	1	Undoubtedly	undoubtedly	RB
cord-261532-q923xxn2	180	2	,	,	,
cord-261532-q923xxn2	180	3	such	such	JJ
cord-261532-q923xxn2	180	4	work	work	NN
cord-261532-q923xxn2	180	5	would	would	MD
cord-261532-q923xxn2	180	6	provide	provide	VB
cord-261532-q923xxn2	180	7	insights	insight	NNS
cord-261532-q923xxn2	180	8	into	into	IN
cord-261532-q923xxn2	180	9	therapeutic	therapeutic	JJ
cord-261532-q923xxn2	180	10	approaches	approach	NNS
cord-261532-q923xxn2	180	11	of	of	IN
cord-261532-q923xxn2	180	12	autoimmune	autoimmune	JJ
cord-261532-q923xxn2	180	13	diseases	disease	NNS
cord-261532-q923xxn2	180	14	.	.	.
cord-261532-q923xxn2	181	1	The	the	DT
cord-261532-q923xxn2	181	2	inflammasome	inflammasome	NN
cord-261532-q923xxn2	181	3	is	be	VBZ
cord-261532-q923xxn2	181	4	a	a	DT
cord-261532-q923xxn2	181	5	multimeric	multimeric	JJ
cord-261532-q923xxn2	181	6	danger	danger	NN
cord-261532-q923xxn2	181	7	-	-	HYPH
cord-261532-q923xxn2	181	8	sensing	sense	VBG
cord-261532-q923xxn2	181	9	platform	platform	NN
cord-261532-q923xxn2	181	10	that	that	WDT
cord-261532-q923xxn2	181	11	mainly	mainly	RB
cord-261532-q923xxn2	181	12	exists	exist	VBZ
cord-261532-q923xxn2	181	13	in	in	IN
cord-261532-q923xxn2	181	14	macrophages	macrophage	NNS
cord-261532-q923xxn2	181	15	and	and	CC
cord-261532-q923xxn2	181	16	dendritic	dendritic	JJ
cord-261532-q923xxn2	181	17	cells	cell	NNS
cord-261532-q923xxn2	181	18	.	.	.
cord-261532-q923xxn2	182	1	Activation	activation	NN
cord-261532-q923xxn2	182	2	of	of	IN
cord-261532-q923xxn2	182	3	the	the	DT
cord-261532-q923xxn2	182	4	inflammasome	inflammasome	NN
cord-261532-q923xxn2	182	5	initiates	initiate	VBZ
cord-261532-q923xxn2	182	6	the	the	DT
cord-261532-q923xxn2	182	7	secretion	secretion	NN
cord-261532-q923xxn2	182	8	of	of	IN
cord-261532-q923xxn2	182	9	IL-1β	il-1β	NN
cord-261532-q923xxn2	182	10	/	/	,
cord-261532-q923xxn2	182	11	IL-18	IL-18	NNP
cord-261532-q923xxn2	182	12	and	and	CC
cord-261532-q923xxn2	182	13	induces	induce	VBZ
cord-261532-q923xxn2	182	14	a	a	DT
cord-261532-q923xxn2	182	15	Caspase-1-dependent	Caspase-1-dependent	NNP
cord-261532-q923xxn2	182	16	cell	cell	NN
cord-261532-q923xxn2	182	17	death	death	NN
cord-261532-q923xxn2	182	18	named	name	VBN
cord-261532-q923xxn2	182	19	"	"	``
cord-261532-q923xxn2	182	20	pyroptosis	pyroptosis	NN
cord-261532-q923xxn2	182	21	"	"	''
cord-261532-q923xxn2	182	22	to	to	TO
cord-261532-q923xxn2	182	23	protect	protect	VB
cord-261532-q923xxn2	182	24	the	the	DT
cord-261532-q923xxn2	182	25	host	host	NN
cord-261532-q923xxn2	182	26	against	against	IN
cord-261532-q923xxn2	182	27	pathogens	pathogen	NNS
cord-261532-q923xxn2	182	28	(	(	-LRB-
cord-261532-q923xxn2	182	29	Schroder	Schroder	NNP
cord-261532-q923xxn2	182	30	and	and	CC
cord-261532-q923xxn2	182	31	Tschopp	Tschopp	NNP
cord-261532-q923xxn2	182	32	,	,	,
cord-261532-q923xxn2	182	33	2010	2010	CD
cord-261532-q923xxn2	182	34	)	)	-RRB-
cord-261532-q923xxn2	182	35	.	.	.
cord-261532-q923xxn2	183	1	Most	Most	JJS
cord-261532-q923xxn2	183	2	inflammasomes	inflammasome	NNS
cord-261532-q923xxn2	183	3	are	be	VBP
cord-261532-q923xxn2	183	4	composed	compose	VBN
cord-261532-q923xxn2	183	5	of	of	IN
cord-261532-q923xxn2	183	6	NLRs	nlr	NNS
cord-261532-q923xxn2	183	7	or	or	CC
cord-261532-q923xxn2	183	8	pyrin	pyrin	NNP
cord-261532-q923xxn2	183	9	and	and	CC
cord-261532-q923xxn2	183	10	hematopoletic	hematopoletic	JJ
cord-261532-q923xxn2	183	11	IFN	IFN	NNP
cord-261532-q923xxn2	183	12	-	-	HYPH
cord-261532-q923xxn2	183	13	inducible	inducible	JJ
cord-261532-q923xxn2	183	14	nuclear	nuclear	JJ
cord-261532-q923xxn2	183	15	proteins	protein	NNS
cord-261532-q923xxn2	183	16	with	with	IN
cord-261532-q923xxn2	183	17	200	200	CD
cord-261532-q923xxn2	183	18	amino	amino	JJ
cord-261532-q923xxn2	183	19	acids	acid	NNS
cord-261532-q923xxn2	183	20	(	(	-LRB-
cord-261532-q923xxn2	183	21	HIN-200	HIN-200	NNP
cord-261532-q923xxn2	183	22	)	)	-RRB-
cord-261532-q923xxn2	183	23	domain	domain	NN
cord-261532-q923xxn2	183	24	(	(	-LRB-
cord-261532-q923xxn2	183	25	PYHIN	PYHIN	NNP
cord-261532-q923xxn2	183	26	)	)	-RRB-
cord-261532-q923xxn2	183	27	family	family	NN
cord-261532-q923xxn2	183	28	members	member	NNS
cord-261532-q923xxn2	183	29	and	and	CC
cord-261532-q923xxn2	183	30	the	the	DT
cord-261532-q923xxn2	183	31	protease	protease	NN
cord-261532-q923xxn2	183	32	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	184	1	(	(	-LRB-
cord-261532-q923xxn2	184	2	Schroder	Schroder	NNP
cord-261532-q923xxn2	184	3	and	and	CC
cord-261532-q923xxn2	184	4	Tschopp	Tschopp	NNP
cord-261532-q923xxn2	184	5	,	,	,
cord-261532-q923xxn2	184	6	2010	2010	CD
cord-261532-q923xxn2	184	7	)	)	-RRB-
cord-261532-q923xxn2	184	8	.	.	.
cord-261532-q923xxn2	185	1	The	the	DT
cord-261532-q923xxn2	185	2	NLRs	nlr	NNS
cord-261532-q923xxn2	185	3	is	be	VBZ
cord-261532-q923xxn2	185	4	a	a	DT
cord-261532-q923xxn2	185	5	large	large	JJ
cord-261532-q923xxn2	185	6	receptor	receptor	NN
cord-261532-q923xxn2	185	7	family	family	NN
cord-261532-q923xxn2	185	8	characterized	characterize	VBN
cord-261532-q923xxn2	185	9	by	by	IN
cord-261532-q923xxn2	185	10	N	n	CD
cord-261532-q923xxn2	185	11	-	-	HYPH
cord-261532-q923xxn2	185	12	terminal	terminal	NN
cord-261532-q923xxn2	185	13	CARD	card	NN
cord-261532-q923xxn2	185	14	or	or	CC
cord-261532-q923xxn2	185	15	pyrin	pyrin	NN
cord-261532-q923xxn2	185	16	domains	domain	NNS
cord-261532-q923xxn2	185	17	(	(	-LRB-
cord-261532-q923xxn2	185	18	PYD	PYD	NNP
cord-261532-q923xxn2	185	19	)	)	-RRB-
cord-261532-q923xxn2	185	20	,	,	,
cord-261532-q923xxn2	185	21	a	a	DT
cord-261532-q923xxn2	185	22	central	central	JJ
cord-261532-q923xxn2	185	23	nucleotide	nucleotide	NN
cord-261532-q923xxn2	185	24	-	-	HYPH
cord-261532-q923xxn2	185	25	binding	bind	VBG
cord-261532-q923xxn2	185	26	and	and	CC
cord-261532-q923xxn2	185	27	oligomerization	oligomerization	NN
cord-261532-q923xxn2	185	28	domain(NOD	domain(NOD	NNP
cord-261532-q923xxn2	185	29	)	)	-RRB-
cord-261532-q923xxn2	185	30	,	,	,
cord-261532-q923xxn2	185	31	and	and	CC
cord-261532-q923xxn2	185	32	C	c	NN
cord-261532-q923xxn2	185	33	-	-	HYPH
cord-261532-q923xxn2	185	34	terminal	terminal	NN
cord-261532-q923xxn2	185	35	leucine	leucine	NN
cord-261532-q923xxn2	185	36	-	-	HYPH
cord-261532-q923xxn2	185	37	rich	rich	JJ
cord-261532-q923xxn2	185	38	repeats	repeat	NNS
cord-261532-q923xxn2	185	39	(	(	-LRB-
cord-261532-q923xxn2	185	40	LRRs	LRRs	NNP
cord-261532-q923xxn2	185	41	)	)	-RRB-
cord-261532-q923xxn2	185	42	responsible	responsible	JJ
cord-261532-q923xxn2	185	43	for	for	IN
cord-261532-q923xxn2	185	44	ligand	ligand	NN
cord-261532-q923xxn2	185	45	sensing	sensing	NN
cord-261532-q923xxn2	185	46	.	.	.
cord-261532-q923xxn2	186	1	To	to	IN
cord-261532-q923xxn2	186	2	date	date	NN
cord-261532-q923xxn2	186	3	,	,	,
cord-261532-q923xxn2	186	4	three	three	CD
cord-261532-q923xxn2	186	5	groups	group	NNS
cord-261532-q923xxn2	186	6	of	of	IN
cord-261532-q923xxn2	186	7	the	the	DT
cord-261532-q923xxn2	186	8	NLR	NLR	NNP
cord-261532-q923xxn2	186	9	family	family	NN
cord-261532-q923xxn2	186	10	:	:	:
cord-261532-q923xxn2	186	11	NLR	NLR	NNP
cord-261532-q923xxn2	186	12	family	family	NN
cord-261532-q923xxn2	186	13	PYD	PYD	NNP
cord-261532-q923xxn2	186	14	-	-	HYPH
cord-261532-q923xxn2	186	15	containing	contain	VBG
cord-261532-q923xxn2	186	16	1	1	CD
cord-261532-q923xxn2	186	17	(	(	-LRB-
cord-261532-q923xxn2	186	18	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	186	19	)	)	-RRB-
cord-261532-q923xxn2	186	20	,	,	,
cord-261532-q923xxn2	186	21	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	186	22	and	and	CC
cord-261532-q923xxn2	186	23	NLR	NLR	NNP
cord-261532-q923xxn2	186	24	family	family	NN
cord-261532-q923xxn2	186	25	CARDcontaining	cardcontaine	VBG
cord-261532-q923xxn2	186	26	4	4	CD
cord-261532-q923xxn2	187	1	(	(	-LRB-
cord-261532-q923xxn2	187	2	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	187	3	)	)	-RRB-
cord-261532-q923xxn2	187	4	are	be	VBP
cord-261532-q923xxn2	187	5	found	find	VBN
cord-261532-q923xxn2	187	6	to	to	TO
cord-261532-q923xxn2	187	7	be	be	VB
cord-261532-q923xxn2	187	8	involved	involve	VBN
cord-261532-q923xxn2	187	9	in	in	IN
cord-261532-q923xxn2	187	10	the	the	DT
cord-261532-q923xxn2	187	11	formation	formation	NN
cord-261532-q923xxn2	187	12	of	of	IN
cord-261532-q923xxn2	187	13	inflammasomes	inflammasome	NNS
cord-261532-q923xxn2	187	14	(	(	-LRB-
cord-261532-q923xxn2	187	15	Kanneganti	Kanneganti	NNP
cord-261532-q923xxn2	187	16	,	,	,
cord-261532-q923xxn2	187	17	2010	2010	CD
cord-261532-q923xxn2	187	18	)	)	-RRB-
cord-261532-q923xxn2	187	19	.	.	.
cord-261532-q923xxn2	188	1	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	189	1	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	189	2	has	have	VBZ
cord-261532-q923xxn2	189	3	been	be	VBN
cord-261532-q923xxn2	189	4	studied	study	VBN
cord-261532-q923xxn2	189	5	most	most	RBS
cord-261532-q923xxn2	189	6	extensively	extensively	RB
cord-261532-q923xxn2	189	7	.	.	.
cord-261532-q923xxn2	190	1	Numerous	numerous	JJ
cord-261532-q923xxn2	190	2	PAMPs	pamp	NNS
cord-261532-q923xxn2	190	3	,	,	,
cord-261532-q923xxn2	190	4	DAMPs	damp	NNS
cord-261532-q923xxn2	190	5	and	and	CC
cord-261532-q923xxn2	190	6	several	several	JJ
cord-261532-q923xxn2	190	7	environment	environment	NN
cord-261532-q923xxn2	190	8	stimulating	stimulate	VBG
cord-261532-q923xxn2	190	9	factors	factor	NNS
cord-261532-q923xxn2	190	10	can	can	MD
cord-261532-q923xxn2	190	11	activate	activate	VB
cord-261532-q923xxn2	190	12	the	the	DT
cord-261532-q923xxn2	190	13	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	190	14	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	190	15	.	.	.
cord-261532-q923xxn2	191	1	The	the	DT
cord-261532-q923xxn2	191	2	Figure	Figure	NNP
cord-261532-q923xxn2	191	3	3	3	CD
cord-261532-q923xxn2	191	4	.	.	.
cord-261532-q923xxn2	192	1	STING	sting	NN
cord-261532-q923xxn2	192	2	-	-	HYPH
cord-261532-q923xxn2	192	3	mediated	mediate	VBN
cord-261532-q923xxn2	192	4	DNA	dna	NN
cord-261532-q923xxn2	192	5	sensing	sensing	NN
cord-261532-q923xxn2	192	6	pathways	pathway	NNS
cord-261532-q923xxn2	192	7	.	.	.
cord-261532-q923xxn2	193	1	DNA	dna	NN
cord-261532-q923xxn2	193	2	viruses	virus	NNS
cord-261532-q923xxn2	193	3	,	,	,
cord-261532-q923xxn2	193	4	bacteria	bacteria	NNS
cord-261532-q923xxn2	193	5	genomic	genomic	JJ
cord-261532-q923xxn2	193	6	DNA	dna	NN
cord-261532-q923xxn2	193	7	and	and	CC
cord-261532-q923xxn2	193	8	unprocessed	unprocessed	JJ
cord-261532-q923xxn2	193	9	endogenous	endogenous	JJ
cord-261532-q923xxn2	193	10	DNA	dna	NN
cord-261532-q923xxn2	193	11	can	can	MD
cord-261532-q923xxn2	193	12	be	be	VB
cord-261532-q923xxn2	193	13	captured	capture	VBN
cord-261532-q923xxn2	193	14	by	by	IN
cord-261532-q923xxn2	193	15	high	high	JJ
cord-261532-q923xxn2	193	16	-	-	HYPH
cord-261532-q923xxn2	193	17	mobility	mobility	NN
cord-261532-q923xxn2	193	18	group	group	NN
cord-261532-q923xxn2	193	19	protein	protein	NN
cord-261532-q923xxn2	193	20	B1	b1	NN
cord-261532-q923xxn2	193	21	(	(	-LRB-
cord-261532-q923xxn2	193	22	HMGB1	HMGB1	NNP
cord-261532-q923xxn2	193	23	)	)	-RRB-
cord-261532-q923xxn2	193	24	and	and	CC
cord-261532-q923xxn2	193	25	then	then	RB
cord-261532-q923xxn2	193	26	recognized	recognize	VBN
cord-261532-q923xxn2	193	27	by	by	IN
cord-261532-q923xxn2	193	28	DAI	DAI	NNP
cord-261532-q923xxn2	193	29	or	or	CC
cord-261532-q923xxn2	193	30	unidentified	unidentified	JJ
cord-261532-q923xxn2	193	31	DNA	DNA	NNP
cord-261532-q923xxn2	193	32	sensor(s	sensor(s	NNP
cord-261532-q923xxn2	193	33	)	)	-RRB-
cord-261532-q923xxn2	193	34	.	.	.
cord-261532-q923xxn2	194	1	Alternatively	alternatively	RB
cord-261532-q923xxn2	194	2	,	,	,
cord-261532-q923xxn2	194	3	dsDNA	dsdna	RB
cord-261532-q923xxn2	194	4	is	be	VBZ
cord-261532-q923xxn2	194	5	transcribed	transcribe	VBN
cord-261532-q923xxn2	194	6	into	into	IN
cord-261532-q923xxn2	194	7	dsRNA	dsRNA	NNS
cord-261532-q923xxn2	194	8	by	by	IN
cord-261532-q923xxn2	194	9	polymerase	polymerase	NN
cord-261532-q923xxn2	194	10	III	III	NNP
cord-261532-q923xxn2	194	11	and	and	CC
cord-261532-q923xxn2	194	12	recognized	recognize	VBN
cord-261532-q923xxn2	194	13	by	by	IN
cord-261532-q923xxn2	194	14	RIG	rig	NN
cord-261532-q923xxn2	194	15	-	-	:
cord-261532-q923xxn2	194	16	I	-PRON-	PRP
cord-261532-q923xxn2	194	17	to	to	TO
cord-261532-q923xxn2	194	18	induce	induce	VB
cord-261532-q923xxn2	194	19	type	type	NN
cord-261532-q923xxn2	194	20	І	і	CD
cord-261532-q923xxn2	194	21	interferons	interferon	NNS
cord-261532-q923xxn2	194	22	.	.	.
cord-261532-q923xxn2	195	1	Upon	upon	IN
cord-261532-q923xxn2	195	2	DNA	dna	NN
cord-261532-q923xxn2	195	3	stimulation	stimulation	NN
cord-261532-q923xxn2	195	4	,	,	,
cord-261532-q923xxn2	195	5	STING	sting	VB
cord-261532-q923xxn2	195	6	translocates	translocate	NNS
cord-261532-q923xxn2	195	7	from	from	IN
cord-261532-q923xxn2	195	8	ER	ER	NNP
cord-261532-q923xxn2	195	9	membrane	membrane	NN
cord-261532-q923xxn2	195	10	to	to	IN
cord-261532-q923xxn2	195	11	the	the	DT
cord-261532-q923xxn2	195	12	cytoplasmic	cytoplasmic	JJ
cord-261532-q923xxn2	195	13	punctate	punctate	NN
cord-261532-q923xxn2	195	14	structure	structure	NN
cord-261532-q923xxn2	195	15	,	,	,
cord-261532-q923xxn2	195	16	where	where	WRB
cord-261532-q923xxn2	195	17	it	-PRON-	PRP
cord-261532-q923xxn2	195	18	interacts	interact	VBZ
cord-261532-q923xxn2	195	19	with	with	IN
cord-261532-q923xxn2	195	20	TBK1	TBK1	NNP
cord-261532-q923xxn2	195	21	and	and	CC
cord-261532-q923xxn2	195	22	activates	activate	VBZ
cord-261532-q923xxn2	195	23	IRF3	IRF3	NNP
cord-261532-q923xxn2	195	24	/	/	SYM
cord-261532-q923xxn2	195	25	IRF7	IRF7	NNP
cord-261532-q923xxn2	195	26	.	.	.
cord-261532-q923xxn2	196	1	oligomerization	oligomerization	NN
cord-261532-q923xxn2	196	2	of	of	IN
cord-261532-q923xxn2	196	3	activated	activate	VBN
cord-261532-q923xxn2	196	4	NLRP3	nlrp3	NN
cord-261532-q923xxn2	196	5	enables	enable	VBZ
cord-261532-q923xxn2	196	6	the	the	DT
cord-261532-q923xxn2	196	7	PYD	PYD	NNP
cord-261532-q923xxn2	196	8	domains	domain	NNS
cord-261532-q923xxn2	196	9	coupling	couple	VBG
cord-261532-q923xxn2	196	10	together	together	RB
cord-261532-q923xxn2	196	11	and	and	CC
cord-261532-q923xxn2	196	12	recruit	recruit	VB
cord-261532-q923xxn2	196	13	ASC	ASC	NNP
cord-261532-q923xxn2	196	14	sequentially	sequentially	RB
cord-261532-q923xxn2	196	15	.	.	.
cord-261532-q923xxn2	197	1	The	the	DT
cord-261532-q923xxn2	197	2	CARD	card	NN
cord-261532-q923xxn2	197	3	domain	domain	NN
cord-261532-q923xxn2	197	4	of	of	IN
cord-261532-q923xxn2	197	5	ASC	ASC	NNP
cord-261532-q923xxn2	197	6	then	then	RB
cord-261532-q923xxn2	197	7	recruits	recruit	VBZ
cord-261532-q923xxn2	197	8	pro	pro	JJ
cord-261532-q923xxn2	197	9	-	-	:
cord-261532-q923xxn2	197	10	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	197	11	which	which	WDT
cord-261532-q923xxn2	197	12	in	in	IN
cord-261532-q923xxn2	197	13	turn	turn	NN
cord-261532-q923xxn2	197	14	self	self	NN
cord-261532-q923xxn2	197	15	-	-	:
cord-261532-q923xxn2	197	16	cleave	cleave	VBP
cord-261532-q923xxn2	197	17	to	to	TO
cord-261532-q923xxn2	197	18	form	form	VB
cord-261532-q923xxn2	197	19	the	the	DT
cord-261532-q923xxn2	197	20	activated	activate	VBN
cord-261532-q923xxn2	197	21	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	197	22	,	,	,
cord-261532-q923xxn2	197	23	namely	namely	RB
cord-261532-q923xxn2	197	24	p10	p10	NN
cord-261532-q923xxn2	197	25	/	/	SYM
cord-261532-q923xxn2	197	26	p20	p20	NNP
cord-261532-q923xxn2	197	27	tetramer	tetramer	NN
cord-261532-q923xxn2	197	28	,	,	,
cord-261532-q923xxn2	197	29	which	which	WDT
cord-261532-q923xxn2	197	30	consequently	consequently	RB
cord-261532-q923xxn2	197	31	cut	cut	VBD
cord-261532-q923xxn2	197	32	pro	pro	JJ
cord-261532-q923xxn2	197	33	-	-	JJ
cord-261532-q923xxn2	197	34	IL-1β	il-1β	JJ
cord-261532-q923xxn2	197	35	into	into	IN
cord-261532-q923xxn2	197	36	its	-PRON-	PRP$
cord-261532-q923xxn2	197	37	mature	mature	JJ
cord-261532-q923xxn2	197	38	form	form	NN
cord-261532-q923xxn2	197	39	.	.	.
cord-261532-q923xxn2	198	1	Recent	recent	JJ
cord-261532-q923xxn2	198	2	work	work	NN
cord-261532-q923xxn2	198	3	suggests	suggest	VBZ
cord-261532-q923xxn2	198	4	that	that	IN
cord-261532-q923xxn2	198	5	NLRC5	NLRC5	``
cord-261532-q923xxn2	198	6	also	also	RB
cord-261532-q923xxn2	198	7	participates	participate	VBZ
cord-261532-q923xxn2	198	8	in	in	IN
cord-261532-q923xxn2	198	9	the	the	DT
cord-261532-q923xxn2	198	10	formation	formation	NN
cord-261532-q923xxn2	198	11	of	of	IN
cord-261532-q923xxn2	198	12	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	198	13	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	198	14	,	,	,
cord-261532-q923xxn2	199	1	because	because	IN
cord-261532-q923xxn2	199	2	bacteria	bacteria	NNS
cord-261532-q923xxn2	199	3	-	-	HYPH
cord-261532-q923xxn2	199	4	induced	induce	VBN
cord-261532-q923xxn2	199	5	NLRP3	nlrp3	NN
cord-261532-q923xxn2	199	6	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	199	7	is	be	VBZ
cord-261532-q923xxn2	199	8	inhibited	inhibit	VBN
cord-261532-q923xxn2	199	9	when	when	WRB
cord-261532-q923xxn2	199	10	silencing	silence	VBG
cord-261532-q923xxn2	199	11	NLRP5	nlrp5	RB
cord-261532-q923xxn2	200	1	(	(	-LRB-
cord-261532-q923xxn2	200	2	Fig	Fig	NNP
cord-261532-q923xxn2	200	3	.	.	.
cord-261532-q923xxn2	201	1	4	4	LS
cord-261532-q923xxn2	201	2	)	)	-RRB-
cord-261532-q923xxn2	201	3	(	(	-LRB-
cord-261532-q923xxn2	201	4	Pétrilli	Pétrilli	NNP
cord-261532-q923xxn2	201	5	et	et	NNP
cord-261532-q923xxn2	201	6	al	al	NNP
cord-261532-q923xxn2	201	7	.	.	NNP
cord-261532-q923xxn2	201	8	,	,	,
cord-261532-q923xxn2	201	9	2007	2007	CD
cord-261532-q923xxn2	201	10	)	)	-RRB-
cord-261532-q923xxn2	201	11	.	.	.
cord-261532-q923xxn2	202	1	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	203	1	(	(	-LRB-
cord-261532-q923xxn2	203	2	or	or	CC
cord-261532-q923xxn2	203	3	IPAF	IPAF	NNP
cord-261532-q923xxn2	203	4	)	)	-RRB-
cord-261532-q923xxn2	204	1	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	204	2	is	be	VBZ
cord-261532-q923xxn2	204	3	mainly	mainly	RB
cord-261532-q923xxn2	204	4	comprised	comprise	VBN
cord-261532-q923xxn2	204	5	of	of	IN
cord-261532-q923xxn2	204	6	NLRP4	nlrp4	NN
cord-261532-q923xxn2	204	7	and	and	CC
cord-261532-q923xxn2	204	8	pro	pro	NNP
cord-261532-q923xxn2	204	9	-	-	HYPH
cord-261532-q923xxn2	204	10	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	204	11	,	,	,
cord-261532-q923xxn2	204	12	and	and	CC
cord-261532-q923xxn2	204	13	is	be	VBZ
cord-261532-q923xxn2	204	14	activated	activate	VBN
cord-261532-q923xxn2	204	15	via	via	IN
cord-261532-q923xxn2	204	16	direct	direct	JJ
cord-261532-q923xxn2	204	17	interaction	interaction	NN
cord-261532-q923xxn2	204	18	with	with	IN
cord-261532-q923xxn2	204	19	the	the	DT
cord-261532-q923xxn2	204	20	CARDs	card	NNS
cord-261532-q923xxn2	204	21	of	of	IN
cord-261532-q923xxn2	204	22	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	204	23	and	and	CC
cord-261532-q923xxn2	204	24	NLRP4	NLRP4	NNP
cord-261532-q923xxn2	204	25	to	to	TO
cord-261532-q923xxn2	204	26	induce	induce	VB
cord-261532-q923xxn2	204	27	Caspase-1-dependent	Caspase-1-dependent	NNP
cord-261532-q923xxn2	204	28	pyroptosis	pyroptosis	NN
cord-261532-q923xxn2	204	29	.	.	.
cord-261532-q923xxn2	205	1	The	the	DT
cord-261532-q923xxn2	205	2	bacterial	bacterial	JJ
cord-261532-q923xxn2	205	3	Type	type	NN
cord-261532-q923xxn2	205	4	III	III	NNP
cord-261532-q923xxn2	205	5	secretion	secretion	NN
cord-261532-q923xxn2	205	6	systems	system	NNS
cord-261532-q923xxn2	205	7	(	(	-LRB-
cord-261532-q923xxn2	205	8	T3SS	t3ss	NN
cord-261532-q923xxn2	205	9	)	)	-RRB-
cord-261532-q923xxn2	205	10	(	(	-LRB-
cord-261532-q923xxn2	205	11	such	such	JJ
cord-261532-q923xxn2	205	12	as	as	IN
cord-261532-q923xxn2	205	13	Salmonella	Salmonella	NNP
cord-261532-q923xxn2	205	14	typhimuurium	typhimuurium	NN
cord-261532-q923xxn2	205	15	,	,	,
cord-261532-q923xxn2	205	16	Listeria	Listeria	NNP
cord-261532-q923xxn2	205	17	,	,	,
cord-261532-q923xxn2	205	18	Francisella	Francisella	NNP
cord-261532-q923xxn2	205	19	or	or	CC
cord-261532-q923xxn2	205	20	Shigella	Shigella	NNP
cord-261532-q923xxn2	205	21	flexneri	flexneri	NNP
cord-261532-q923xxn2	205	22	)	)	-RRB-
cord-261532-q923xxn2	205	23	is	be	VBZ
cord-261532-q923xxn2	205	24	essential	essential	JJ
cord-261532-q923xxn2	205	25	for	for	IN
cord-261532-q923xxn2	205	26	the	the	DT
cord-261532-q923xxn2	205	27	activation	activation	NN
cord-261532-q923xxn2	205	28	of	of	IN
cord-261532-q923xxn2	205	29	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	205	30	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	205	31	(	(	-LRB-
cord-261532-q923xxn2	205	32	Zhao	Zhao	NNP
cord-261532-q923xxn2	205	33	et	et	NNP
cord-261532-q923xxn2	205	34	al	al	NNP
cord-261532-q923xxn2	205	35	.	.	NNP
cord-261532-q923xxn2	205	36	,	,	,
cord-261532-q923xxn2	205	37	2011	2011	CD
cord-261532-q923xxn2	205	38	;	;	:
cord-261532-q923xxn2	205	39	Kofoed	Kofoed	NNP
cord-261532-q923xxn2	205	40	and	and	CC
cord-261532-q923xxn2	205	41	Vance	Vance	NNP
cord-261532-q923xxn2	205	42	,	,	,
cord-261532-q923xxn2	205	43	2011	2011	CD
cord-261532-q923xxn2	205	44	)	)	-RRB-
cord-261532-q923xxn2	205	45	.	.	.
cord-261532-q923xxn2	206	1	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	206	2	is	be	VBZ
cord-261532-q923xxn2	206	3	the	the	DT
cord-261532-q923xxn2	206	4	first	first	JJ
cord-261532-q923xxn2	206	5	receptor	receptor	NN
cord-261532-q923xxn2	206	6	in	in	IN
cord-261532-q923xxn2	206	7	NLR	NLR	NNP
cord-261532-q923xxn2	206	8	family	family	NN
cord-261532-q923xxn2	206	9	that	that	WDT
cord-261532-q923xxn2	206	10	is	be	VBZ
cord-261532-q923xxn2	206	11	found	find	VBN
cord-261532-q923xxn2	206	12	to	to	TO
cord-261532-q923xxn2	206	13	be	be	VB
cord-261532-q923xxn2	206	14	involved	involve	VBN
cord-261532-q923xxn2	206	15	in	in	IN
cord-261532-q923xxn2	206	16	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	206	17	assembly	assembly	NNP
cord-261532-q923xxn2	206	18	and	and	CC
cord-261532-q923xxn2	206	19	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	206	20	activation	activation	NN
cord-261532-q923xxn2	206	21	.	.	.
cord-261532-q923xxn2	207	1	Homo	homo	NN
cord-261532-q923xxn2	208	1	sapiens	sapiens	NNP
cord-261532-q923xxn2	209	1	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	209	2	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	209	3	is	be	VBZ
cord-261532-q923xxn2	209	4	composed	compose	VBN
cord-261532-q923xxn2	209	5	of	of	IN
cord-261532-q923xxn2	209	6	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	209	7	,	,	,
cord-261532-q923xxn2	209	8	ASC	ASC	NNP
cord-261532-q923xxn2	209	9	,	,	,
cord-261532-q923xxn2	209	10	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	209	11	and	and	CC
cord-261532-q923xxn2	209	12	Caspase-5	Caspase-5	NNP
cord-261532-q923xxn2	209	13	,	,	,
cord-261532-q923xxn2	209	14	which	which	WDT
cord-261532-q923xxn2	209	15	mainly	mainly	RB
cord-261532-q923xxn2	209	16	recognizes	recognize	VBZ
cord-261532-q923xxn2	209	17	muramyl	muramyl	NNP
cord-261532-q923xxn2	209	18	dipeptide	dipeptide	NNP
cord-261532-q923xxn2	209	19	(	(	-LRB-
cord-261532-q923xxn2	209	20	MDP	MDP	NNP
cord-261532-q923xxn2	209	21	)	)	-RRB-
cord-261532-q923xxn2	209	22	deriving	derive	VBG
cord-261532-q923xxn2	209	23	from	from	IN
cord-261532-q923xxn2	209	24	bacterial	bacterial	JJ
cord-261532-q923xxn2	209	25	peptidoglycan	peptidoglycan	NN
cord-261532-q923xxn2	209	26	.	.	.
cord-261532-q923xxn2	210	1	As	as	IN
cord-261532-q923xxn2	210	2	the	the	DT
cord-261532-q923xxn2	210	3	only	only	JJ
cord-261532-q923xxn2	210	4	NLR	NLR	NNP
cord-261532-q923xxn2	210	5	receptor	receptor	NN
cord-261532-q923xxn2	210	6	containing	contain	VBG
cord-261532-q923xxn2	210	7	an	an	DT
cord-261532-q923xxn2	210	8	extra	extra	JJ
cord-261532-q923xxn2	210	9	C	c	NN
cord-261532-q923xxn2	210	10	-	-	HYPH
cord-261532-q923xxn2	210	11	terminal	terminal	NN
cord-261532-q923xxn2	210	12	CARD	card	NN
cord-261532-q923xxn2	210	13	domain	domain	NN
cord-261532-q923xxn2	210	14	,	,	,
cord-261532-q923xxn2	210	15	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	210	16	can	can	MD
cord-261532-q923xxn2	210	17	recruit	recruit	VB
cord-261532-q923xxn2	210	18	pro	pro	JJ
cord-261532-q923xxn2	210	19	-	-	:
cord-261532-q923xxn2	210	20	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	210	21	directly	directly	RB
cord-261532-q923xxn2	210	22	,	,	,
cord-261532-q923xxn2	210	23	but	but	CC
cord-261532-q923xxn2	210	24	ASC	ASC	NNP
cord-261532-q923xxn2	210	25	can	can	MD
cord-261532-q923xxn2	210	26	upregulate	upregulate	VB
cord-261532-q923xxn2	210	27	the	the	DT
cord-261532-q923xxn2	210	28	activation	activation	NN
cord-261532-q923xxn2	210	29	of	of	IN
cord-261532-q923xxn2	210	30	human	human	JJ
cord-261532-q923xxn2	210	31	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	210	32	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	210	33	.	.	.
cord-261532-q923xxn2	211	1	Murine	Murine	NNP
cord-261532-q923xxn2	211	2	NLRP1	NLRP1	NNS
cord-261532-q923xxn2	211	3	has	have	VBZ
cord-261532-q923xxn2	211	4	three	three	CD
cord-261532-q923xxn2	211	5	homology	homology	NN
cord-261532-q923xxn2	211	6	proteins	protein	NNS
cord-261532-q923xxn2	211	7	:	:	:
cord-261532-q923xxn2	212	1	NLRP1a	NLRP1a	NNP
cord-261532-q923xxn2	212	2	,	,	,
cord-261532-q923xxn2	212	3	NLRP1b	nlrp1b	NN
cord-261532-q923xxn2	212	4	and	and	CC
cord-261532-q923xxn2	212	5	NLRP1c	NLRP1c	NNP
cord-261532-q923xxn2	212	6	,	,	,
cord-261532-q923xxn2	212	7	among	among	IN
cord-261532-q923xxn2	212	8	which	which	WDT
cord-261532-q923xxn2	212	9	,	,	,
cord-261532-q923xxn2	212	10	NLRP1b	nlrp1b	NN
cord-261532-q923xxn2	212	11	can	can	MD
cord-261532-q923xxn2	212	12	be	be	VB
cord-261532-q923xxn2	212	13	activated	activate	VBN
cord-261532-q923xxn2	212	14	by	by	IN
cord-261532-q923xxn2	212	15	lethal	lethal	JJ
cord-261532-q923xxn2	212	16	factor	factor	NN
cord-261532-q923xxn2	212	17	(	(	-LRB-
cord-261532-q923xxn2	212	18	LF	LF	NNP
cord-261532-q923xxn2	212	19	)	)	-RRB-
cord-261532-q923xxn2	212	20	from	from	IN
cord-261532-q923xxn2	212	21	anthrax	anthrax	NN
cord-261532-q923xxn2	212	22	toxin	toxin	NN
cord-261532-q923xxn2	212	23	.	.	.
cord-261532-q923xxn2	213	1	Hence	hence	RB
cord-261532-q923xxn2	213	2	,	,	,
cord-261532-q923xxn2	213	3	it	-PRON-	PRP
cord-261532-q923xxn2	213	4	is	be	VBZ
cord-261532-q923xxn2	213	5	still	still	RB
cord-261532-q923xxn2	213	6	contorversial	contorversial	JJ
cord-261532-q923xxn2	213	7	whether	whether	IN
cord-261532-q923xxn2	213	8	MDP	MDP	NNP
cord-261532-q923xxn2	213	9	can	can	MD
cord-261532-q923xxn2	213	10	activate	activate	VB
cord-261532-q923xxn2	213	11	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	213	12	directly	directly	RB
cord-261532-q923xxn2	213	13	,	,	,
cord-261532-q923xxn2	213	14	and	and	CC
cord-261532-q923xxn2	213	15	it	-PRON-	PRP
cord-261532-q923xxn2	213	16	is	be	VBZ
cord-261532-q923xxn2	213	17	reported	report	VBN
cord-261532-q923xxn2	213	18	that	that	IN
cord-261532-q923xxn2	213	19	NOD2	NOD2	NNP
cord-261532-q923xxn2	213	20	(	(	-LRB-
cord-261532-q923xxn2	213	21	NLRC2	NLRC2	NNP
cord-261532-q923xxn2	213	22	)	)	-RRB-
cord-261532-q923xxn2	213	23	serves	serve	VBZ
cord-261532-q923xxn2	213	24	as	as	IN
cord-261532-q923xxn2	213	25	the	the	DT
cord-261532-q923xxn2	213	26	intracellular	intracellular	JJ
cord-261532-q923xxn2	213	27	receptor	receptor	NN
cord-261532-q923xxn2	213	28	for	for	IN
cord-261532-q923xxn2	213	29	MDP	MDP	NNP
cord-261532-q923xxn2	213	30	and	and	CC
cord-261532-q923xxn2	213	31	participates	participate	VBZ
cord-261532-q923xxn2	213	32	in	in	IN
cord-261532-q923xxn2	213	33	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	213	34	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	213	35	assembly	assembly	NNP
cord-261532-q923xxn2	213	36	.	.	.
cord-261532-q923xxn2	214	1	The	the	DT
cord-261532-q923xxn2	214	2	PYHIN	PYHIN	NNP
cord-261532-q923xxn2	214	3	family	family	NN
cord-261532-q923xxn2	214	4	comprises	comprise	VBZ
cord-261532-q923xxn2	214	5	of	of	IN
cord-261532-q923xxn2	214	6	four	four	CD
cord-261532-q923xxn2	214	7	members	member	NNS
cord-261532-q923xxn2	214	8	:	:	:
cord-261532-q923xxn2	215	1	IFNinducible	ifninducible	JJ
cord-261532-q923xxn2	215	2	protein	protein	NN
cord-261532-q923xxn2	215	3	X	X	NNP
cord-261532-q923xxn2	215	4	(	(	-LRB-
cord-261532-q923xxn2	215	5	IFIX	IFIX	NNP
cord-261532-q923xxn2	215	6	)	)	-RRB-
cord-261532-q923xxn2	215	7	,	,	,
cord-261532-q923xxn2	215	8	IFI16	IFI16	NNP
cord-261532-q923xxn2	215	9	,	,	,
cord-261532-q923xxn2	215	10	myeloid	myeloid	JJ
cord-261532-q923xxn2	215	11	nuclear	nuclear	JJ
cord-261532-q923xxn2	215	12	differentiation	differentiation	NN
cord-261532-q923xxn2	215	13	antigen	antigen	NN
cord-261532-q923xxn2	215	14	(	(	-LRB-
cord-261532-q923xxn2	215	15	MNDA	MNDA	NNP
cord-261532-q923xxn2	215	16	)	)	-RRB-
cord-261532-q923xxn2	215	17	and	and	CC
cord-261532-q923xxn2	215	18	AIM2	AIM2	NNP
cord-261532-q923xxn2	215	19	,	,	,
cord-261532-q923xxn2	215	20	and	and	CC
cord-261532-q923xxn2	215	21	their	-PRON-	PRP$
cord-261532-q923xxn2	215	22	C	c	NN
cord-261532-q923xxn2	215	23	-	-	HYPH
cord-261532-q923xxn2	215	24	terminal	terminal	NN
cord-261532-q923xxn2	215	25	HIN	HIN	NNP
cord-261532-q923xxn2	215	26	domain	domain	NN
cord-261532-q923xxn2	215	27	is	be	VBZ
cord-261532-q923xxn2	215	28	in	in	IN
cord-261532-q923xxn2	215	29	charge	charge	NN
cord-261532-q923xxn2	215	30	of	of	IN
cord-261532-q923xxn2	215	31	sensing	sense	VBG
cord-261532-q923xxn2	215	32	DNA	DNA	NNP
cord-261532-q923xxn2	215	33	and	and	CC
cord-261532-q923xxn2	215	34	N	n	CD
cord-261532-q923xxn2	215	35	-	-	HYPH
cord-261532-q923xxn2	215	36	terminal	terminal	JJ
cord-261532-q923xxn2	215	37	PYD	PYD	NNP
cord-261532-q923xxn2	215	38	domain	domain	NN
cord-261532-q923xxn2	215	39	recruits	recruit	VBZ
cord-261532-q923xxn2	215	40	downstream	downstream	JJ
cord-261532-q923xxn2	215	41	adaptor	adaptor	NN
cord-261532-q923xxn2	215	42	ASC	ASC	NNP
cord-261532-q923xxn2	215	43	(	(	-LRB-
cord-261532-q923xxn2	215	44	Bürckstümmer	Bürckstümmer	NNP
cord-261532-q923xxn2	215	45	et	et	NNP
cord-261532-q923xxn2	215	46	al	al	NNP
cord-261532-q923xxn2	215	47	.	.	NNP
cord-261532-q923xxn2	215	48	,	,	,
cord-261532-q923xxn2	215	49	2009	2009	CD
cord-261532-q923xxn2	215	50	;	;	.
cord-261532-q923xxn2	216	1	Fernandes	Fernandes	NNP
cord-261532-q923xxn2	216	2	-	-	HYPH
cord-261532-q923xxn2	216	3	Alnemri	Alnemri	NNP
cord-261532-q923xxn2	216	4	et	et	NNP
cord-261532-q923xxn2	216	5	al	al	NNP
cord-261532-q923xxn2	216	6	.	.	.
cord-261532-q923xxn2	217	1	,	,	,
cord-261532-q923xxn2	217	2	2009	2009	CD
cord-261532-q923xxn2	217	3	;	;	:
cord-261532-q923xxn2	217	4	Hornung	Hornung	NNP
cord-261532-q923xxn2	217	5	et	et	NNP
cord-261532-q923xxn2	217	6	al	al	NNP
cord-261532-q923xxn2	217	7	.	.	.
cord-261532-q923xxn2	218	1	,	,	,
cord-261532-q923xxn2	218	2	2009	2009	CD
cord-261532-q923xxn2	218	3	;	;	:
cord-261532-q923xxn2	218	4	Roberts	Roberts	NNP
cord-261532-q923xxn2	218	5	et	et	NNP
cord-261532-q923xxn2	218	6	al	al	NNP
cord-261532-q923xxn2	218	7	.	.	NNP
cord-261532-q923xxn2	218	8	,	,	,
cord-261532-q923xxn2	218	9	2009	2009	CD
cord-261532-q923xxn2	218	10	.	.	.
cord-261532-q923xxn2	218	11	)	)	-RRB-
cord-261532-q923xxn2	219	1	AIM2	AIM2	NNP
cord-261532-q923xxn2	219	2	acts	act	VBZ
cord-261532-q923xxn2	219	3	as	as	IN
cord-261532-q923xxn2	219	4	a	a	DT
cord-261532-q923xxn2	219	5	intracellular	intracellular	JJ
cord-261532-q923xxn2	219	6	receptor	receptor	NN
cord-261532-q923xxn2	219	7	for	for	IN
cord-261532-q923xxn2	219	8	alien	alien	JJ
cord-261532-q923xxn2	219	9	or	or	CC
cord-261532-q923xxn2	219	10	endogenous	endogenous	JJ
cord-261532-q923xxn2	219	11	dsDNA	dsdna	RB
cord-261532-q923xxn2	219	12	to	to	TO
cord-261532-q923xxn2	219	13	induce	induce	VB
cord-261532-q923xxn2	219	14	Caspase-1-dependent	Caspase-1-dependent	NNP
cord-261532-q923xxn2	219	15	maturation	maturation	NN
cord-261532-q923xxn2	219	16	of	of	IN
cord-261532-q923xxn2	219	17	IL-1β	il-1β	NN
cord-261532-q923xxn2	219	18	/	/	,
cord-261532-q923xxn2	219	19	IL-18	IL-18	NNP
cord-261532-q923xxn2	219	20	and	and	CC
cord-261532-q923xxn2	219	21	cell	cell	NN
cord-261532-q923xxn2	219	22	death	death	NN
cord-261532-q923xxn2	219	23	like	like	IN
cord-261532-q923xxn2	219	24	pyroptosis	pyroptosis	NNP
cord-261532-q923xxn2	219	25	.	.	.
cord-261532-q923xxn2	220	1	The	the	DT
cord-261532-q923xxn2	220	2	immune	immune	JJ
cord-261532-q923xxn2	220	3	functions	function	NNS
cord-261532-q923xxn2	220	4	of	of	IN
cord-261532-q923xxn2	220	5	other	other	JJ
cord-261532-q923xxn2	220	6	HIN-200	HIN-200	NNP
cord-261532-q923xxn2	220	7	family	family	NN
cord-261532-q923xxn2	220	8	members	member	NNS
cord-261532-q923xxn2	220	9	(	(	-LRB-
cord-261532-q923xxn2	220	10	MNDA	MNDA	NNP
cord-261532-q923xxn2	220	11	,	,	,
cord-261532-q923xxn2	220	12	IFI16	ifi16	NN
cord-261532-q923xxn2	220	13	and	and	CC
cord-261532-q923xxn2	220	14	IFIX	IFIX	NNP
cord-261532-q923xxn2	220	15	)	)	-RRB-
cord-261532-q923xxn2	220	16	remain	remain	VBP
cord-261532-q923xxn2	220	17	unclear	unclear	JJ
cord-261532-q923xxn2	220	18	.	.	.
cord-261532-q923xxn2	220	19	.	.	.
cord-261532-q923xxn2	221	1	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	222	1	、	、	NN
cord-261532-q923xxn2	223	1	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	223	2	、	、	NNP
cord-261532-q923xxn2	223	3	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	223	4	and	and	CC
cord-261532-q923xxn2	223	5	AIM2	AIM2	NNP
cord-261532-q923xxn2	223	6	inflammasomes	inflammasome	NNS
cord-261532-q923xxn2	223	7	.	.	.
cord-261532-q923xxn2	224	1	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	224	2	,	,	,
cord-261532-q923xxn2	225	1	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	225	2	and	and	CC
cord-261532-q923xxn2	225	3	AIM2	AIM2	NNP
cord-261532-q923xxn2	225	4	recruit	recruit	VBP
cord-261532-q923xxn2	225	5	and	and	CC
cord-261532-q923xxn2	225	6	activate	activate	VB
cord-261532-q923xxn2	225	7	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	225	8	through	through	IN
cord-261532-q923xxn2	225	9	the	the	DT
cord-261532-q923xxn2	225	10	bridging	bridge	VBG
cord-261532-q923xxn2	225	11	molecule	molecule	NN
cord-261532-q923xxn2	225	12	ASC	ASC	NNP
cord-261532-q923xxn2	225	13	,	,	,
cord-261532-q923xxn2	225	14	and	and	CC
cord-261532-q923xxn2	225	15	the	the	DT
cord-261532-q923xxn2	225	16	CARD	card	NN
cord-261532-q923xxn2	225	17	domain	domain	NN
cord-261532-q923xxn2	225	18	of	of	IN
cord-261532-q923xxn2	225	19	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	225	20	is	be	VBZ
cord-261532-q923xxn2	225	21	removed	remove	VBN
cord-261532-q923xxn2	225	22	by	by	IN
cord-261532-q923xxn2	225	23	autocleavage	autocleavage	NN
cord-261532-q923xxn2	225	24	resulting	result	VBG
cord-261532-q923xxn2	225	25	in	in	IN
cord-261532-q923xxn2	225	26	the	the	DT
cord-261532-q923xxn2	225	27	formation	formation	NN
cord-261532-q923xxn2	225	28	of	of	IN
cord-261532-q923xxn2	225	29	the	the	DT
cord-261532-q923xxn2	225	30	activated	activate	VBN
cord-261532-q923xxn2	225	31	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	225	32	p10/20	p10/20	NNP
cord-261532-q923xxn2	225	33	tetramer	tetramer	NN
cord-261532-q923xxn2	225	34	.	.	.
cord-261532-q923xxn2	226	1	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	226	2	directly	directly	RB
cord-261532-q923xxn2	226	3	binds	bind	VBZ
cord-261532-q923xxn2	226	4	to	to	IN
cord-261532-q923xxn2	226	5	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	226	6	and	and	CC
cord-261532-q923xxn2	226	7	induces	induce	VBZ
cord-261532-q923xxn2	226	8	the	the	DT
cord-261532-q923xxn2	226	9	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	226	10	assembly	assembly	NNP
cord-261532-q923xxn2	226	11	,	,	,
cord-261532-q923xxn2	226	12	yet	yet	CC
cord-261532-q923xxn2	226	13	there	there	EX
cord-261532-q923xxn2	226	14	are	be	VBP
cord-261532-q923xxn2	226	15	several	several	JJ
cord-261532-q923xxn2	226	16	reports	report	NNS
cord-261532-q923xxn2	226	17	that	that	WDT
cord-261532-q923xxn2	226	18	stress	stress	VBP
cord-261532-q923xxn2	226	19	the	the	DT
cord-261532-q923xxn2	226	20	requirement	requirement	NN
cord-261532-q923xxn2	226	21	for	for	IN
cord-261532-q923xxn2	226	22	ASC	ASC	NNP
cord-261532-q923xxn2	226	23	in	in	IN
cord-261532-q923xxn2	226	24	the	the	DT
cord-261532-q923xxn2	226	25	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	226	26	inflammasome	inflammasome	NN
cord-261532-q923xxn2	226	27	.	.	.
cord-261532-q923xxn2	227	1	Currently	currently	RB
cord-261532-q923xxn2	227	2	,	,	,
cord-261532-q923xxn2	227	3	there	there	EX
cord-261532-q923xxn2	227	4	mainly	mainly	RB
cord-261532-q923xxn2	227	5	exists	exist	VBZ
cord-261532-q923xxn2	227	6	three	three	CD
cord-261532-q923xxn2	227	7	models	model	NNS
cord-261532-q923xxn2	227	8	for	for	IN
cord-261532-q923xxn2	227	9	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	227	10	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	227	11	activation	activation	NN
cord-261532-q923xxn2	227	12	:	:	:
cord-261532-q923xxn2	228	1	First	first	RB
cord-261532-q923xxn2	228	2	,	,	,
cord-261532-q923xxn2	228	3	the	the	DT
cord-261532-q923xxn2	228	4	NLRP3	nlrp3	NN
cord-261532-q923xxn2	228	5	agonist	agonist	NN
cord-261532-q923xxn2	228	6	,	,	,
cord-261532-q923xxn2	228	7	ATP	ATP	NNP
cord-261532-q923xxn2	228	8	,	,	,
cord-261532-q923xxn2	228	9	triggers	trigger	VBZ
cord-261532-q923xxn2	228	10	P2X7-dependent	P2X7-dependent	NNP
cord-261532-q923xxn2	228	11	pore	pore	NN
cord-261532-q923xxn2	228	12	formation	formation	NN
cord-261532-q923xxn2	228	13	or	or	CC
cord-261532-q923xxn2	228	14	pore	pore	NN
cord-261532-q923xxn2	228	15	forming	form	VBG
cord-261532-q923xxn2	228	16	toxins	toxin	NNS
cord-261532-q923xxn2	228	17	initiate	initiate	VBP
cord-261532-q923xxn2	228	18	the	the	DT
cord-261532-q923xxn2	228	19	efflux	efflux	NN
cord-261532-q923xxn2	228	20	of	of	IN
cord-261532-q923xxn2	228	21	potassium	potassium	NN
cord-261532-q923xxn2	228	22	,	,	,
cord-261532-q923xxn2	228	23	which	which	WDT
cord-261532-q923xxn2	228	24	directly	directly	RB
cord-261532-q923xxn2	228	25	elicit	elicit	VBP
cord-261532-q923xxn2	228	26	the	the	DT
cord-261532-q923xxn2	228	27	assembly	assembly	NN
cord-261532-q923xxn2	228	28	of	of	IN
cord-261532-q923xxn2	228	29	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	228	30	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	228	31	by	by	IN
cord-261532-q923xxn2	228	32	a	a	DT
cord-261532-q923xxn2	228	33	yet	yet	RB
cord-261532-q923xxn2	228	34	-	-	HYPH
cord-261532-q923xxn2	228	35	unknown	unknown	JJ
cord-261532-q923xxn2	228	36	mechanism	mechanism	NN
cord-261532-q923xxn2	228	37	.	.	.
cord-261532-q923xxn2	229	1	Second	second	RB
cord-261532-q923xxn2	229	2	,	,	,
cord-261532-q923xxn2	229	3	engulfed	engulf	VBN
cord-261532-q923xxn2	229	4	crystalline	crystalline	NN
cord-261532-q923xxn2	229	5	and	and	CC
cord-261532-q923xxn2	229	6	the	the	DT
cord-261532-q923xxn2	229	7	lysosomal	lysosomal	JJ
cord-261532-q923xxn2	229	8	protease	protease	NN
cord-261532-q923xxn2	229	9	cathepsin	cathepsin	NN
cord-261532-q923xxn2	229	10	B	B	NNP
cord-261532-q923xxn2	229	11	plays	play	VBZ
cord-261532-q923xxn2	229	12	an	an	DT
cord-261532-q923xxn2	229	13	important	important	JJ
cord-261532-q923xxn2	229	14	role	role	NN
cord-261532-q923xxn2	229	15	in	in	IN
cord-261532-q923xxn2	229	16	the	the	DT
cord-261532-q923xxn2	229	17	formation	formation	NN
cord-261532-q923xxn2	229	18	of	of	IN
cord-261532-q923xxn2	229	19	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	229	20	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	229	21	.	.	.
cord-261532-q923xxn2	230	1	Third	third	RB
cord-261532-q923xxn2	230	2	,	,	,
cord-261532-q923xxn2	230	3	all	all	DT
cord-261532-q923xxn2	230	4	of	of	IN
cord-261532-q923xxn2	230	5	DAMPs	damp	NNS
cord-261532-q923xxn2	230	6	and	and	CC
cord-261532-q923xxn2	230	7	PAMPs	pamp	NNS
cord-261532-q923xxn2	230	8	,	,	,
cord-261532-q923xxn2	230	9	including	include	VBG
cord-261532-q923xxn2	230	10	ATP	ATP	NNP
cord-261532-q923xxn2	230	11	and	and	CC
cord-261532-q923xxn2	230	12	crystalline	crystalline	JJ
cord-261532-q923xxn2	230	13	activators	activator	NNS
cord-261532-q923xxn2	230	14	can	can	MD
cord-261532-q923xxn2	230	15	induce	induce	VB
cord-261532-q923xxn2	230	16	the	the	DT
cord-261532-q923xxn2	230	17	formation	formation	NN
cord-261532-q923xxn2	230	18	of	of	IN
cord-261532-q923xxn2	230	19	reactive	reactive	JJ
cord-261532-q923xxn2	230	20	oxygen	oxygen	NN
cord-261532-q923xxn2	230	21	species	specie	NNS
cord-261532-q923xxn2	230	22	(	(	-LRB-
cord-261532-q923xxn2	230	23	ROS	ROS	NNP
cord-261532-q923xxn2	230	24	)	)	-RRB-
cord-261532-q923xxn2	230	25	,	,	,
cord-261532-q923xxn2	230	26	which	which	WDT
cord-261532-q923xxn2	230	27	indirectly	indirectly	RB
cord-261532-q923xxn2	230	28	activate	activate	VBP
cord-261532-q923xxn2	230	29	NLRP3	NLRP3	NNP
cord-261532-q923xxn2	230	30	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	230	31	by	by	IN
cord-261532-q923xxn2	230	32	a	a	DT
cord-261532-q923xxn2	230	33	yet	yet	RB
cord-261532-q923xxn2	230	34	-	-	HYPH
cord-261532-q923xxn2	230	35	unidentified	unidentified	JJ
cord-261532-q923xxn2	230	36	manner	manner	NN
cord-261532-q923xxn2	230	37	.	.	.
cord-261532-q923xxn2	231	1	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	231	2	clustering	clustering	NN
cord-261532-q923xxn2	231	3	induces	induce	VBZ
cord-261532-q923xxn2	231	4	autoactivation	autoactivation	NN
cord-261532-q923xxn2	231	5	and	and	CC
cord-261532-q923xxn2	231	6	caspase-1-dependent	caspase-1-dependent	JJ
cord-261532-q923xxn2	231	7	maturation	maturation	NN
cord-261532-q923xxn2	231	8	and	and	CC
cord-261532-q923xxn2	231	9	secretion	secretion	NN
cord-261532-q923xxn2	231	10	of	of	IN
cord-261532-q923xxn2	231	11	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	231	12	cytokines	cytokine	NNS
cord-261532-q923xxn2	231	13	,	,	,
cord-261532-q923xxn2	231	14	such	such	JJ
cord-261532-q923xxn2	231	15	as	as	IN
cord-261532-q923xxn2	231	16	IL-1β	IL-1β	NNP
cord-261532-q923xxn2	231	17	.	.	.
cord-261532-q923xxn2	232	1	STAT6	STAT6	NNP
cord-261532-q923xxn2	232	2	belongs	belong	VBZ
cord-261532-q923xxn2	232	3	to	to	IN
cord-261532-q923xxn2	232	4	the	the	DT
cord-261532-q923xxn2	232	5	Signal	Signal	NNP
cord-261532-q923xxn2	232	6	Transducer	Transducer	NNP
cord-261532-q923xxn2	232	7	and	and	CC
cord-261532-q923xxn2	232	8	Activator	Activator	NNP
cord-261532-q923xxn2	232	9	of	of	IN
cord-261532-q923xxn2	232	10	Transcription	Transcription	NNP
cord-261532-q923xxn2	232	11	family	family	NN
cord-261532-q923xxn2	232	12	of	of	IN
cord-261532-q923xxn2	232	13	proteins	protein	NNS
cord-261532-q923xxn2	232	14	.	.	.
cord-261532-q923xxn2	233	1	In	in	IN
cord-261532-q923xxn2	233	2	mammals	mammal	NNS
cord-261532-q923xxn2	233	3	,	,	,
cord-261532-q923xxn2	233	4	there	there	EX
cord-261532-q923xxn2	233	5	are	be	VBP
cord-261532-q923xxn2	233	6	seven	seven	CD
cord-261532-q923xxn2	233	7	members	member	NNS
cord-261532-q923xxn2	233	8	:	:	:
cord-261532-q923xxn2	233	9	STAT1	stat1	XX
cord-261532-q923xxn2	233	10	,	,	,
cord-261532-q923xxn2	233	11	-2	-2	NNP
cord-261532-q923xxn2	233	12	,	,	,
cord-261532-q923xxn2	233	13	-3	-3	NNP
cord-261532-q923xxn2	233	14	,	,	,
cord-261532-q923xxn2	233	15	-4	-4	NNP
cord-261532-q923xxn2	233	16	,	,	,
cord-261532-q923xxn2	233	17	-5a	-5a	NNP
cord-261532-q923xxn2	233	18	,	,	,
cord-261532-q923xxn2	233	19	-5b	-5b	CD
cord-261532-q923xxn2	234	1	and	and	CC
cord-261532-q923xxn2	234	2	-6	-6	NNP
cord-261532-q923xxn2	234	3	(	(	-LRB-
cord-261532-q923xxn2	234	4	Brierley	Brierley	NNP
cord-261532-q923xxn2	234	5	and	and	CC
cord-261532-q923xxn2	234	6	Fish	Fish	NNP
cord-261532-q923xxn2	234	7	,	,	,
cord-261532-q923xxn2	234	8	2005	2005	CD
cord-261532-q923xxn2	234	9	)	)	-RRB-
cord-261532-q923xxn2	234	10	.	.	.
cord-261532-q923xxn2	235	1	These	these	DT
cord-261532-q923xxn2	235	2	proteins	protein	NNS
cord-261532-q923xxn2	235	3	transmit	transmit	VBP
cord-261532-q923xxn2	235	4	signals	signal	NNS
cord-261532-q923xxn2	235	5	from	from	IN
cord-261532-q923xxn2	235	6	a	a	DT
cord-261532-q923xxn2	235	7	receptor	receptor	NN
cord-261532-q923xxn2	235	8	complex	complex	NN
cord-261532-q923xxn2	235	9	to	to	IN
cord-261532-q923xxn2	235	10	the	the	DT
cord-261532-q923xxn2	235	11	nucleus	nucleus	NN
cord-261532-q923xxn2	235	12	and	and	CC
cord-261532-q923xxn2	235	13	activate	activate	VB
cord-261532-q923xxn2	235	14	gene	gene	NN
cord-261532-q923xxn2	235	15	expression	expression	NN
cord-261532-q923xxn2	235	16	,	,	,
cord-261532-q923xxn2	235	17	known	know	VBN
cord-261532-q923xxn2	235	18	as	as	IN
cord-261532-q923xxn2	235	19	the	the	DT
cord-261532-q923xxn2	235	20	classical	classical	JJ
cord-261532-q923xxn2	235	21	JAK	JAK	NNP
cord-261532-q923xxn2	235	22	-	-	HYPH
cord-261532-q923xxn2	235	23	STAT	STAT	NNP
cord-261532-q923xxn2	235	24	pathways．STAT6	pathways．STAT6	NNP
cord-261532-q923xxn2	235	25	mainly	mainly	RB
cord-261532-q923xxn2	235	26	participates	participate	VBZ
cord-261532-q923xxn2	235	27	in	in	IN
cord-261532-q923xxn2	235	28	IL-4	IL-4	NNP
cord-261532-q923xxn2	235	29	/	/	SYM
cord-261532-q923xxn2	235	30	IL-13-mediated	il-13-mediated	JJ
cord-261532-q923xxn2	235	31	allergic	allergic	JJ
cord-261532-q923xxn2	235	32	reaction	reaction	NN
cord-261532-q923xxn2	235	33	,	,	,
cord-261532-q923xxn2	235	34	playing	play	VBG
cord-261532-q923xxn2	235	35	a	a	DT
cord-261532-q923xxn2	235	36	vital	vital	JJ
cord-261532-q923xxn2	235	37	role	role	NN
cord-261532-q923xxn2	235	38	in	in	IN
cord-261532-q923xxn2	235	39	the	the	DT
cord-261532-q923xxn2	235	40	differentiation	differentiation	NN
cord-261532-q923xxn2	235	41	of	of	IN
cord-261532-q923xxn2	235	42	T	t	NN
cord-261532-q923xxn2	235	43	-	-	HYPH
cord-261532-q923xxn2	235	44	helper	helper	NN
cord-261532-q923xxn2	235	45	type	type	NN
cord-261532-q923xxn2	235	46	2	2	CD
cord-261532-q923xxn2	235	47	(	(	-LRB-
cord-261532-q923xxn2	235	48	Th2	Th2	NNP
cord-261532-q923xxn2	235	49	)	)	-RRB-
cord-261532-q923xxn2	235	50	cells	cell	NNS
cord-261532-q923xxn2	235	51	(	(	-LRB-
cord-261532-q923xxn2	235	52	Hebenstreit	Hebenstreit	NNP
cord-261532-q923xxn2	235	53	et	et	NNP
cord-261532-q923xxn2	235	54	al	al	NNP
cord-261532-q923xxn2	235	55	.	.	NNP
cord-261532-q923xxn2	235	56	,	,	,
cord-261532-q923xxn2	235	57	2006	2006	CD
cord-261532-q923xxn2	235	58	;	;	:
cord-261532-q923xxn2	235	59	Chapoval	Chapoval	NNP
cord-261532-q923xxn2	235	60	et	et	NNP
cord-261532-q923xxn2	235	61	al	al	NNP
cord-261532-q923xxn2	235	62	.	.	NNP
cord-261532-q923xxn2	235	63	,	,	,
cord-261532-q923xxn2	235	64	2010	2010	CD
cord-261532-q923xxn2	235	65	)	)	-RRB-
cord-261532-q923xxn2	235	66	.	.	.
cord-261532-q923xxn2	236	1	The	the	DT
cord-261532-q923xxn2	236	2	Homo	Homo	NNP
cord-261532-q923xxn2	237	1	sapiens	sapiens	NNP
cord-261532-q923xxn2	238	1	STAT6	stat6	NN
cord-261532-q923xxn2	238	2	gene	gene	NN
cord-261532-q923xxn2	238	3	maps	map	NNS
cord-261532-q923xxn2	238	4	to	to	TO
cord-261532-q923xxn2	238	5	chromosome	chromosome	VB
cord-261532-q923xxn2	238	6	12q13.3-q14.1	12q13.3-q14.1	NN
cord-261532-q923xxn2	238	7	,	,	,
cord-261532-q923xxn2	238	8	while	while	IN
cord-261532-q923xxn2	238	9	Mus	Mus	NNP
cord-261532-q923xxn2	238	10	musculus	musculus	NN
cord-261532-q923xxn2	238	11	Stat6	Stat6	NNP
cord-261532-q923xxn2	238	12	gene	gene	NN
cord-261532-q923xxn2	238	13	lies	lie	VBZ
cord-261532-q923xxn2	238	14	clustered	cluster	VBN
cord-261532-q923xxn2	238	15	in	in	IN
cord-261532-q923xxn2	238	16	the	the	DT
cord-261532-q923xxn2	238	17	distal	distal	JJ
cord-261532-q923xxn2	238	18	region	region	NN
cord-261532-q923xxn2	238	19	of	of	IN
cord-261532-q923xxn2	238	20	murine	murine	JJ
cord-261532-q923xxn2	238	21	chromosome	chromosome	NN
cord-261532-q923xxn2	238	22	10	10	CD
cord-261532-q923xxn2	238	23	.	.	.
cord-261532-q923xxn2	239	1	This	this	DT
cord-261532-q923xxn2	239	2	protein	protein	NN
cord-261532-q923xxn2	239	3	is	be	VBZ
cord-261532-q923xxn2	239	4	ubiquitously	ubiquitously	RB
cord-261532-q923xxn2	239	5	expressed	express	VBN
cord-261532-q923xxn2	239	6	,	,	,
cord-261532-q923xxn2	239	7	especially	especially	RB
cord-261532-q923xxn2	239	8	plentiful	plentiful	JJ
cord-261532-q923xxn2	239	9	in	in	IN
cord-261532-q923xxn2	239	10	B	b	NN
cord-261532-q923xxn2	239	11	and	and	CC
cord-261532-q923xxn2	239	12	T	t	NN
cord-261532-q923xxn2	239	13	cells	cell	NNS
cord-261532-q923xxn2	239	14	,	,	,
cord-261532-q923xxn2	239	15	and	and	CC
cord-261532-q923xxn2	239	16	constantly	constantly	RB
cord-261532-q923xxn2	239	17	active	active	JJ
cord-261532-q923xxn2	239	18	in	in	IN
cord-261532-q923xxn2	239	19	most	most	JJS
cord-261532-q923xxn2	239	20	cell	cell	NN
cord-261532-q923xxn2	239	21	types	type	NNS
cord-261532-q923xxn2	239	22	.	.	.
cord-261532-q923xxn2	240	1	Human	human	JJ
cord-261532-q923xxn2	240	2	STAT6	stat6	NN
cord-261532-q923xxn2	240	3	consists	consist	VBZ
cord-261532-q923xxn2	240	4	of	of	IN
cord-261532-q923xxn2	240	5	847	847	CD
cord-261532-q923xxn2	240	6	amino	amino	JJ
cord-261532-q923xxn2	240	7	acids	acid	NNS
cord-261532-q923xxn2	240	8	(	(	-LRB-
cord-261532-q923xxn2	240	9	murine	murine	JJ
cord-261532-q923xxn2	240	10	837	837	CD
cord-261532-q923xxn2	240	11	amino	amino	JJ
cord-261532-q923xxn2	240	12	acids	acid	NNS
cord-261532-q923xxn2	240	13	)	)	-RRB-
cord-261532-q923xxn2	240	14	,	,	,
cord-261532-q923xxn2	240	15	which	which	WDT
cord-261532-q923xxn2	240	16	specifies	specify	VBZ
cord-261532-q923xxn2	240	17	a	a	DT
cord-261532-q923xxn2	240	18	size	size	NN
cord-261532-q923xxn2	240	19	of	of	IN
cord-261532-q923xxn2	240	20	94	94	CD
cord-261532-q923xxn2	240	21	kDa	kDa	NNS
cord-261532-q923xxn2	240	22	in	in	IN
cord-261532-q923xxn2	240	23	an	an	DT
cord-261532-q923xxn2	240	24	unmodified	unmodified	JJ
cord-261532-q923xxn2	240	25	state	state	NN
cord-261532-q923xxn2	240	26	.	.	.
cord-261532-q923xxn2	241	1	It	-PRON-	PRP
cord-261532-q923xxn2	241	2	contains	contain	VBZ
cord-261532-q923xxn2	241	3	an	an	DT
cord-261532-q923xxn2	241	4	N	n	CD
cord-261532-q923xxn2	241	5	-	-	HYPH
cord-261532-q923xxn2	241	6	terminal	terminal	NN
cord-261532-q923xxn2	241	7	α	α	NNP
cord-261532-q923xxn2	241	8	-	-	HYPH
cord-261532-q923xxn2	241	9	Helix	Helix	NNP
cord-261532-q923xxn2	241	10	domain	domain	NN
cord-261532-q923xxn2	241	11	,	,	,
cord-261532-q923xxn2	241	12	a	a	DT
cord-261532-q923xxn2	241	13	DNA	dna	NN
cord-261532-q923xxn2	241	14	binding	binding	NN
cord-261532-q923xxn2	241	15	domain	domain	NN
cord-261532-q923xxn2	241	16	(	(	-LRB-
cord-261532-q923xxn2	241	17	DBD	DBD	NNP
cord-261532-q923xxn2	241	18	)	)	-RRB-
cord-261532-q923xxn2	241	19	,	,	,
cord-261532-q923xxn2	241	20	a	a	DT
cord-261532-q923xxn2	241	21	linker	linker	NN
cord-261532-q923xxn2	241	22	domain	domain	NN
cord-261532-q923xxn2	241	23	(	(	-LRB-
cord-261532-q923xxn2	241	24	LD	LD	NNP
cord-261532-q923xxn2	241	25	)	)	-RRB-
cord-261532-q923xxn2	241	26	,	,	,
cord-261532-q923xxn2	241	27	a	a	DT
cord-261532-q923xxn2	241	28	Src	Src	NNP
cord-261532-q923xxn2	241	29	homology	homology	NN
cord-261532-q923xxn2	241	30	2	2	CD
cord-261532-q923xxn2	241	31	(	(	-LRB-
cord-261532-q923xxn2	241	32	SH2	SH2	NNP
cord-261532-q923xxn2	241	33	)	)	-RRB-
cord-261532-q923xxn2	241	34	domain	domain	NN
cord-261532-q923xxn2	241	35	and	and	CC
cord-261532-q923xxn2	241	36	a	a	DT
cord-261532-q923xxn2	241	37	C	c	NN
cord-261532-q923xxn2	241	38	-	-	HYPH
cord-261532-q923xxn2	241	39	terminal	terminal	NN
cord-261532-q923xxn2	241	40	transactivation	transactivation	NN
cord-261532-q923xxn2	241	41	domain	domain	NN
cord-261532-q923xxn2	241	42	(	(	-LRB-
cord-261532-q923xxn2	241	43	TAD	tad	NN
cord-261532-q923xxn2	241	44	)	)	-RRB-
cord-261532-q923xxn2	242	1	(	(	-LRB-
cord-261532-q923xxn2	242	2	Fig	Fig	NNP
cord-261532-q923xxn2	242	3	.	.	.
cord-261532-q923xxn2	243	1	5	5	LS
cord-261532-q923xxn2	243	2	)	)	-RRB-
cord-261532-q923xxn2	243	3	(	(	-LRB-
cord-261532-q923xxn2	243	4	Hebenstreit	Hebenstreit	NNP
cord-261532-q923xxn2	243	5	et	et	NNP
cord-261532-q923xxn2	243	6	al	al	NNP
cord-261532-q923xxn2	243	7	.	.	NNP
cord-261532-q923xxn2	243	8	,	,	,
cord-261532-q923xxn2	243	9	2006	2006	CD
cord-261532-q923xxn2	243	10	)	)	-RRB-
cord-261532-q923xxn2	243	11	.	.	.
cord-261532-q923xxn2	244	1	The	the	DT
cord-261532-q923xxn2	244	2	N	N	NNP
cord-261532-q923xxn2	244	3	-	-	HYPH
cord-261532-q923xxn2	244	4	terminus	terminus	NN
cord-261532-q923xxn2	244	5	of	of	IN
cord-261532-q923xxn2	244	6	STAT6	stat6	NN
cord-261532-q923xxn2	244	7	enriches	enrich	VBZ
cord-261532-q923xxn2	244	8	α	α	XX
cord-261532-q923xxn2	244	9	-	-	HYPH
cord-261532-q923xxn2	244	10	Helix	Helix	NNP
cord-261532-q923xxn2	244	11	motif	motif	NN
cord-261532-q923xxn2	244	12	,	,	,
cord-261532-q923xxn2	244	13	namely	namely	RB
cord-261532-q923xxn2	244	14	coiled	coil	VBN
cord-261532-q923xxn2	244	15	-	-	HYPH
cord-261532-q923xxn2	244	16	coil	coil	NN
cord-261532-q923xxn2	244	17	domain	domain	NN
cord-261532-q923xxn2	244	18	.	.	.
cord-261532-q923xxn2	245	1	Recent	recent	JJ
cord-261532-q923xxn2	245	2	publications	publication	NNS
cord-261532-q923xxn2	245	3	have	have	VBP
cord-261532-q923xxn2	245	4	demonstrated	demonstrate	VBN
cord-261532-q923xxn2	245	5	that	that	IN
cord-261532-q923xxn2	245	6	the	the	DT
cord-261532-q923xxn2	245	7	N	n	CD
cord-261532-q923xxn2	245	8	-	-	HYPH
cord-261532-q923xxn2	245	9	terminus	terminus	NN
cord-261532-q923xxn2	245	10	of	of	IN
cord-261532-q923xxn2	245	11	STATs	STATs	NNP
cord-261532-q923xxn2	245	12	is	be	VBZ
cord-261532-q923xxn2	245	13	involved	involve	VBN
cord-261532-q923xxn2	245	14	in	in	IN
cord-261532-q923xxn2	245	15	its	-PRON-	PRP$
cord-261532-q923xxn2	245	16	interaction	interaction	NN
cord-261532-q923xxn2	245	17	with	with	IN
cord-261532-q923xxn2	245	18	receptors	receptor	NNS
cord-261532-q923xxn2	245	19	,	,	,
cord-261532-q923xxn2	245	20	and	and	CC
cord-261532-q923xxn2	245	21	the	the	DT
cord-261532-q923xxn2	245	22	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	245	23	,	,	,
cord-261532-q923xxn2	245	24	nuclear	nuclear	JJ
cord-261532-q923xxn2	245	25	translocation	translocation	NN
cord-261532-q923xxn2	245	26	of	of	IN
cord-261532-q923xxn2	245	27	STATs	stat	NNS
cord-261532-q923xxn2	245	28	,	,	,
cord-261532-q923xxn2	245	29	However	however	RB
cord-261532-q923xxn2	245	30	,	,	,
cord-261532-q923xxn2	245	31	it	-PRON-	PRP
cord-261532-q923xxn2	245	32	remains	remain	VBZ
cord-261532-q923xxn2	245	33	to	to	TO
cord-261532-q923xxn2	245	34	be	be	VB
cord-261532-q923xxn2	245	35	seen	see	VBN
cord-261532-q923xxn2	245	36	whether	whether	IN
cord-261532-q923xxn2	245	37	these	these	DT
cord-261532-q923xxn2	245	38	findings	finding	NNS
cord-261532-q923xxn2	245	39	have	have	VBP
cord-261532-q923xxn2	245	40	functional	functional	JJ
cord-261532-q923xxn2	245	41	relevance	relevance	NN
cord-261532-q923xxn2	245	42	to	to	IN
cord-261532-q923xxn2	245	43	STAT6	stat6	NN
cord-261532-q923xxn2	245	44	,	,	,
cord-261532-q923xxn2	245	45	as	as	IN
cord-261532-q923xxn2	245	46	an	an	DT
cord-261532-q923xxn2	245	47	isoform	isoform	NN
cord-261532-q923xxn2	245	48	of	of	IN
cord-261532-q923xxn2	245	49	STAT6	STAT6	NNS
cord-261532-q923xxn2	245	50	truncated	truncate	VBN
cord-261532-q923xxn2	245	51	at	at	IN
cord-261532-q923xxn2	245	52	N	n	CD
cord-261532-q923xxn2	245	53	-	-	HYPH
cord-261532-q923xxn2	245	54	terminus	terminus	NN
cord-261532-q923xxn2	245	55	appears	appear	VBZ
cord-261532-q923xxn2	245	56	to	to	TO
cord-261532-q923xxn2	245	57	be	be	VB
cord-261532-q923xxn2	245	58	fully	fully	RB
cord-261532-q923xxn2	245	59	functional	functional	JJ
cord-261532-q923xxn2	245	60	.	.	.
cord-261532-q923xxn2	246	1	The	the	DT
cord-261532-q923xxn2	246	2	DBD	DBD	NNP
cord-261532-q923xxn2	246	3	of	of	IN
cord-261532-q923xxn2	246	4	STAT6	stat6	NN
cord-261532-q923xxn2	246	5	extends	extend	VBZ
cord-261532-q923xxn2	246	6	from	from	IN
cord-261532-q923xxn2	246	7	posi	posi	JJ
cord-261532-q923xxn2	246	8	-	-	HYPH
cord-261532-q923xxn2	246	9	tions	tion	NNS
cord-261532-q923xxn2	246	10	268	268	CD
cord-261532-q923xxn2	246	11	to	to	IN
cord-261532-q923xxn2	246	12	430	430	CD
cord-261532-q923xxn2	246	13	,	,	,
cord-261532-q923xxn2	246	14	allowing	allow	VBG
cord-261532-q923xxn2	246	15	DNA	dna	NN
cord-261532-q923xxn2	246	16	binding	binding	NN
cord-261532-q923xxn2	246	17	when	when	WRB
cord-261532-q923xxn2	246	18	STAT6	stat6	NN
cord-261532-q923xxn2	246	19	is	be	VBZ
cord-261532-q923xxn2	246	20	present	present	JJ
cord-261532-q923xxn2	246	21	as	as	IN
cord-261532-q923xxn2	246	22	a	a	DT
cord-261532-q923xxn2	246	23	dimer	dimer	NN
cord-261532-q923xxn2	246	24	.	.	.
cord-261532-q923xxn2	247	1	We	-PRON-	PRP
cord-261532-q923xxn2	247	2	previously	previously	RB
cord-261532-q923xxn2	247	3	reported	report	VBD
cord-261532-q923xxn2	247	4	that	that	IN
cord-261532-q923xxn2	247	5	Ser	Ser	NNP
cord-261532-q923xxn2	247	6	407	407	CD
cord-261532-q923xxn2	247	7	in	in	IN
cord-261532-q923xxn2	247	8	DBD	DBD	NNP
cord-261532-q923xxn2	247	9	is	be	VBZ
cord-261532-q923xxn2	247	10	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	247	11	by	by	IN
cord-261532-q923xxn2	247	12	TBK1	TBK1	NNP
cord-261532-q923xxn2	247	13	after	after	IN
cord-261532-q923xxn2	247	14	virus	virus	NN
cord-261532-q923xxn2	247	15	infection	infection	NN
cord-261532-q923xxn2	247	16	,	,	,
cord-261532-q923xxn2	247	17	but	but	CC
cord-261532-q923xxn2	247	18	the	the	DT
cord-261532-q923xxn2	247	19	biological	biological	JJ
cord-261532-q923xxn2	247	20	significance	significance	NN
cord-261532-q923xxn2	247	21	of	of	IN
cord-261532-q923xxn2	247	22	this	this	DT
cord-261532-q923xxn2	247	23	modification	modification	NN
cord-261532-q923xxn2	247	24	remains	remain	VBZ
cord-261532-q923xxn2	247	25	unclear	unclear	JJ
cord-261532-q923xxn2	247	26	.	.	.
cord-261532-q923xxn2	248	1	The	the	DT
cord-261532-q923xxn2	248	2	SH2	SH2	NNP
cord-261532-q923xxn2	248	3	domain	domain	NN
cord-261532-q923xxn2	248	4	of	of	IN
cord-261532-q923xxn2	248	5	STAT6	stat6	NN
cord-261532-q923xxn2	248	6	has	have	VBZ
cord-261532-q923xxn2	248	7	been	be	VBN
cord-261532-q923xxn2	248	8	shown	show	VBN
cord-261532-q923xxn2	248	9	essential	essential	JJ
cord-261532-q923xxn2	248	10	for	for	IN
cord-261532-q923xxn2	248	11	its	-PRON-	PRP$
cord-261532-q923xxn2	248	12	binding	binding	NN
cord-261532-q923xxn2	248	13	to	to	IN
cord-261532-q923xxn2	248	14	phosphorylated	phosphorylated	JJ
cord-261532-q923xxn2	248	15	tyrosine	tyrosine	NN
cord-261532-q923xxn2	248	16	residues	residue	NNS
cord-261532-q923xxn2	248	17	on	on	IN
cord-261532-q923xxn2	248	18	the	the	DT
cord-261532-q923xxn2	248	19	cytoplasmic	cytoplasmic	JJ
cord-261532-q923xxn2	248	20	tail	tail	NN
cord-261532-q923xxn2	248	21	of	of	IN
cord-261532-q923xxn2	248	22	the	the	DT
cord-261532-q923xxn2	248	23	receptor	receptor	NN
cord-261532-q923xxn2	248	24	and	and	CC
cord-261532-q923xxn2	248	25	its	-PRON-	PRP$
cord-261532-q923xxn2	248	26	own	own	JJ
cord-261532-q923xxn2	248	27	dimerization	dimerization	NN
cord-261532-q923xxn2	248	28	,	,	,
cord-261532-q923xxn2	248	29	followed	follow	VBN
cord-261532-q923xxn2	248	30	by	by	IN
cord-261532-q923xxn2	248	31	the	the	DT
cord-261532-q923xxn2	248	32	reciprocal	reciprocal	JJ
cord-261532-q923xxn2	248	33	interaction	interaction	NN
cord-261532-q923xxn2	248	34	of	of	IN
cord-261532-q923xxn2	248	35	the	the	DT
cord-261532-q923xxn2	248	36	SH2	SH2	NNP
cord-261532-q923xxn2	248	37	domain	domain	NN
cord-261532-q923xxn2	248	38	with	with	IN
cord-261532-q923xxn2	248	39	a	a	DT
cord-261532-q923xxn2	248	40	phosphorylated	phosphorylated	JJ
cord-261532-q923xxn2	248	41	tyrosine	tyrosine	NN
cord-261532-q923xxn2	248	42	at	at	IN
cord-261532-q923xxn2	248	43	position	position	NN
cord-261532-q923xxn2	248	44	641	641	CD
cord-261532-q923xxn2	248	45	.	.	.
cord-261532-q923xxn2	249	1	Our	-PRON-	PRP$
cord-261532-q923xxn2	249	2	work	work	NN
cord-261532-q923xxn2	249	3	suggested	suggest	VBD
cord-261532-q923xxn2	249	4	that	that	IN
cord-261532-q923xxn2	249	5	when	when	WRB
cord-261532-q923xxn2	249	6	the	the	DT
cord-261532-q923xxn2	249	7	L	L	NNP
cord-261532-q923xxn2	249	8	551	551	CD
cord-261532-q923xxn2	249	9	in	in	IN
cord-261532-q923xxn2	249	10	SH2	SH2	NNP
cord-261532-q923xxn2	249	11	is	be	VBZ
cord-261532-q923xxn2	249	12	mutated	mutate	VBN
cord-261532-q923xxn2	249	13	,	,	,
cord-261532-q923xxn2	249	14	STAT6	STAT6	NNS
cord-261532-q923xxn2	249	15	can	can	MD
cord-261532-q923xxn2	249	16	still	still	RB
cord-261532-q923xxn2	249	17	be	be	VB
cord-261532-q923xxn2	249	18	activated	activate	VBN
cord-261532-q923xxn2	249	19	by	by	IN
cord-261532-q923xxn2	249	20	IL-4	IL-4	NNP
cord-261532-q923xxn2	249	21	but	but	CC
cord-261532-q923xxn2	249	22	not	not	RB
cord-261532-q923xxn2	249	23	virus	virus	NN
cord-261532-q923xxn2	249	24	infection	infection	NN
cord-261532-q923xxn2	249	25	.	.	.
cord-261532-q923xxn2	250	1	STAT6	STAT6	NNP
cord-261532-q923xxn2	250	2	has	have	VBZ
cord-261532-q923xxn2	250	3	the	the	DT
cord-261532-q923xxn2	250	4	longest	long	JJS
cord-261532-q923xxn2	250	5	TAD	tad	NN
cord-261532-q923xxn2	250	6	among	among	IN
cord-261532-q923xxn2	250	7	STAT	stat	NN
cord-261532-q923xxn2	250	8	family	family	NN
cord-261532-q923xxn2	250	9	members	member	NNS
cord-261532-q923xxn2	250	10	,	,	,
cord-261532-q923xxn2	250	11	which	which	WDT
cord-261532-q923xxn2	250	12	is	be	VBZ
cord-261532-q923xxn2	250	13	147	147	CD
cord-261532-q923xxn2	250	14	amino	amino	JJ
cord-261532-q923xxn2	250	15	acids	acid	NNS
cord-261532-q923xxn2	250	16	in	in	IN
cord-261532-q923xxn2	250	17	length	length	NN
cord-261532-q923xxn2	250	18	and	and	CC
cord-261532-q923xxn2	250	19	is	be	VBZ
cord-261532-q923xxn2	250	20	rich	rich	JJ
cord-261532-q923xxn2	250	21	of	of	IN
cord-261532-q923xxn2	250	22	proline	proline	NN
cord-261532-q923xxn2	250	23	residues	residue	NNS
cord-261532-q923xxn2	250	24	.	.	.
cord-261532-q923xxn2	251	1	STAT6	STAT6	NNP
cord-261532-q923xxn2	251	2	displays	display	VBZ
cord-261532-q923xxn2	251	3	a	a	DT
cord-261532-q923xxn2	251	4	dominant	dominant	JJ
cord-261532-q923xxn2	251	5	-	-	HYPH
cord-261532-q923xxn2	251	6	negative	negative	JJ
cord-261532-q923xxn2	251	7	feature	feature	NN
cord-261532-q923xxn2	251	8	without	without	IN
cord-261532-q923xxn2	251	9	TAD	TAD	NNP
cord-261532-q923xxn2	251	10	.	.	.
cord-261532-q923xxn2	252	1	S	S	NNP
cord-261532-q923xxn2	252	2	756	756	CD
cord-261532-q923xxn2	252	3	in	in	IN
cord-261532-q923xxn2	252	4	TAD	TAD	NNP
cord-261532-q923xxn2	252	5	can	can	MD
cord-261532-q923xxn2	252	6	be	be	VB
cord-261532-q923xxn2	252	7	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	252	8	after	after	IN
cord-261532-q923xxn2	252	9	IL-4	IL-4	NNP
cord-261532-q923xxn2	252	10	stimulation	stimulation	NN
cord-261532-q923xxn2	252	11	,	,	,
cord-261532-q923xxn2	252	12	but	but	CC
cord-261532-q923xxn2	252	13	further	further	JJ
cord-261532-q923xxn2	252	14	studies	study	NNS
cord-261532-q923xxn2	252	15	are	be	VBP
cord-261532-q923xxn2	252	16	needed	need	VBN
cord-261532-q923xxn2	252	17	to	to	TO
cord-261532-q923xxn2	252	18	unravel	unravel	VB
cord-261532-q923xxn2	252	19	its	-PRON-	PRP$
cord-261532-q923xxn2	252	20	functional	functional	JJ
cord-261532-q923xxn2	252	21	significance	significance	NN
cord-261532-q923xxn2	252	22	.	.	.
cord-261532-q923xxn2	253	1	The	the	DT
cord-261532-q923xxn2	253	2	canonical	canonical	JJ
cord-261532-q923xxn2	253	3	IL-4	IL-4	NNP
cord-261532-q923xxn2	253	4	/	/	SYM
cord-261532-q923xxn2	253	5	IL-13	IL-13	NNP
cord-261532-q923xxn2	253	6	signaling	signal	VBG
cord-261532-q923xxn2	253	7	pathways	pathway	NNS
cord-261532-q923xxn2	254	1	STAT6	stat6	NN
cord-261532-q923xxn2	254	2	is	be	VBZ
cord-261532-q923xxn2	254	3	classically	classically	RB
cord-261532-q923xxn2	254	4	involved	involve	VBN
cord-261532-q923xxn2	254	5	in	in	IN
cord-261532-q923xxn2	254	6	the	the	DT
cord-261532-q923xxn2	254	7	IL-4	IL-4	NNP
cord-261532-q923xxn2	254	8	/	/	SYM
cord-261532-q923xxn2	254	9	IL-13	IL-13	NNP
cord-261532-q923xxn2	254	10	signaling	signal	VBG
cord-261532-q923xxn2	254	11	(	(	-LRB-
cord-261532-q923xxn2	254	12	Fig	Fig	NNP
cord-261532-q923xxn2	254	13	.	.	.
cord-261532-q923xxn2	254	14	 	 	_SP
cord-261532-q923xxn2	254	15	6	6	CD
cord-261532-q923xxn2	254	16	right	right	NN
cord-261532-q923xxn2	254	17	)	)	-RRB-
cord-261532-q923xxn2	254	18	.	.	.
cord-261532-q923xxn2	255	1	The	the	DT
cord-261532-q923xxn2	255	2	cytokines	cytokine	NNS
cord-261532-q923xxn2	255	3	IL-4	IL-4	NNP
cord-261532-q923xxn2	255	4	/	/	SYM
cord-261532-q923xxn2	255	5	IL-13	IL-13	NNP
cord-261532-q923xxn2	255	6	are	be	VBP
cord-261532-q923xxn2	255	7	produced	produce	VBN
cord-261532-q923xxn2	255	8	by	by	IN
cord-261532-q923xxn2	255	9	Th2	Th2	NNP
cord-261532-q923xxn2	255	10	cells	cell	NNS
cord-261532-q923xxn2	255	11	,	,	,
cord-261532-q923xxn2	255	12	mast	mast	NN
cord-261532-q923xxn2	255	13	cells	cell	NNS
cord-261532-q923xxn2	255	14	and	and	CC
cord-261532-q923xxn2	255	15	basophils	basophil	NNS
cord-261532-q923xxn2	255	16	.	.	.
cord-261532-q923xxn2	256	1	These	these	DT
cord-261532-q923xxn2	256	2	two	two	CD
cord-261532-q923xxn2	256	3	cytokines	cytokine	NNS
cord-261532-q923xxn2	256	4	share	share	VBP
cord-261532-q923xxn2	256	5	similar	similar	JJ
cord-261532-q923xxn2	256	6	physiological	physiological	JJ
cord-261532-q923xxn2	256	7	functions	function	NNS
cord-261532-q923xxn2	256	8	and	and	CC
cord-261532-q923xxn2	256	9	are	be	VBP
cord-261532-q923xxn2	256	10	implicated	implicate	VBN
cord-261532-q923xxn2	256	11	in	in	IN
cord-261532-q923xxn2	256	12	pathological	pathological	JJ
cord-261532-q923xxn2	256	13	conditions	condition	NNS
cord-261532-q923xxn2	256	14	such	such	JJ
cord-261532-q923xxn2	256	15	as	as	IN
cord-261532-q923xxn2	256	16	asthma	asthma	NN
cord-261532-q923xxn2	256	17	,	,	,
cord-261532-q923xxn2	256	18	allergy	allergy	NN
cord-261532-q923xxn2	256	19	and	and	CC
cord-261532-q923xxn2	256	20	autoimmune	autoimmune	JJ
cord-261532-q923xxn2	256	21	diseases	disease	NNS
cord-261532-q923xxn2	256	22	.	.	.
cord-261532-q923xxn2	257	1	Nevertheless	nevertheless	RB
cord-261532-q923xxn2	257	2	,	,	,
cord-261532-q923xxn2	257	3	IL-4	IL-4	NNP
cord-261532-q923xxn2	257	4	is	be	VBZ
cord-261532-q923xxn2	257	5	more	more	RBR
cord-261532-q923xxn2	257	6	active	active	JJ
cord-261532-q923xxn2	257	7	regulating	regulate	VBG
cord-261532-q923xxn2	257	8	Th2	th2	CD
cord-261532-q923xxn2	257	9	cells	cell	NNS
cord-261532-q923xxn2	257	10	development	development	NN
cord-261532-q923xxn2	257	11	,	,	,
cord-261532-q923xxn2	257	12	whereas	whereas	IN
cord-261532-q923xxn2	257	13	IL-13	IL-13	NNP
cord-261532-q923xxn2	257	14	is	be	VBZ
cord-261532-q923xxn2	257	15	more	more	RBR
cord-261532-q923xxn2	257	16	involved	involved	JJ
cord-261532-q923xxn2	257	17	in	in	IN
cord-261532-q923xxn2	257	18	the	the	DT
cord-261532-q923xxn2	257	19	regulation	regulation	NN
cord-261532-q923xxn2	257	20	on	on	IN
cord-261532-q923xxn2	257	21	respiratory	respiratory	JJ
cord-261532-q923xxn2	257	22	hypersensitivity	hypersensitivity	NN
cord-261532-q923xxn2	257	23	,	,	,
cord-261532-q923xxn2	257	24	mucus	mucus	NN
cord-261532-q923xxn2	257	25	hypersecretion	hypersecretion	NN
cord-261532-q923xxn2	257	26	and	and	CC
cord-261532-q923xxn2	257	27	Th2-type	Th2-type	NNP
cord-261532-q923xxn2	257	28	inflammation	inflammation	NN
cord-261532-q923xxn2	257	29	of	of	IN
cord-261532-q923xxn2	257	30	the	the	DT
cord-261532-q923xxn2	257	31	bowel	bowel	NN
cord-261532-q923xxn2	257	32	.	.	.
cord-261532-q923xxn2	258	1	The	the	DT
cord-261532-q923xxn2	258	2	receptors	receptor	NNS
cord-261532-q923xxn2	258	3	for	for	IN
cord-261532-q923xxn2	258	4	IL-4	IL-4	NNP
cord-261532-q923xxn2	258	5	and	and	CC
cord-261532-q923xxn2	258	6	IL-13	IL-13	NNP
cord-261532-q923xxn2	258	7	share	share	VBP
cord-261532-q923xxn2	258	8	several	several	JJ
cord-261532-q923xxn2	258	9	features	feature	NNS
cord-261532-q923xxn2	258	10	including	include	VBG
cord-261532-q923xxn2	258	11	four	four	CD
cord-261532-q923xxn2	258	12	conserved	conserve	VBN
cord-261532-q923xxn2	258	13	cysteine	cysteine	NN
cord-261532-q923xxn2	258	14	residues	residue	NNS
cord-261532-q923xxn2	258	15	,	,	,
cord-261532-q923xxn2	258	16	a	a	DT
cord-261532-q923xxn2	258	17	WSXWS	WSXWS	NNP
cord-261532-q923xxn2	258	18	motif	motif	NN
cord-261532-q923xxn2	258	19	,	,	,
cord-261532-q923xxn2	258	20	fibronectin	fibronectin	NN
cord-261532-q923xxn2	258	21	type	type	NN
cord-261532-q923xxn2	258	22	III	iii	CD
cord-261532-q923xxn2	258	23	modules	module	NNS
cord-261532-q923xxn2	258	24	in	in	IN
cord-261532-q923xxn2	258	25	the	the	DT
cord-261532-q923xxn2	258	26	extracellular	extracellular	JJ
cord-261532-q923xxn2	258	27	domain	domain	NN
cord-261532-q923xxn2	258	28	and	and	CC
cord-261532-q923xxn2	258	29	proline	proline	NN
cord-261532-q923xxn2	258	30	-	-	HYPH
cord-261532-q923xxn2	258	31	rich	rich	JJ
cord-261532-q923xxn2	258	32	box	box	NN
cord-261532-q923xxn2	258	33	regions	region	NNS
cord-261532-q923xxn2	258	34	in	in	IN
cord-261532-q923xxn2	258	35	the	the	DT
cord-261532-q923xxn2	258	36	intracellular	intracellular	JJ
cord-261532-q923xxn2	258	37	domain	domain	NN
cord-261532-q923xxn2	258	38	,	,	,
cord-261532-q923xxn2	258	39	which	which	WDT
cord-261532-q923xxn2	258	40	are	be	VBP
cord-261532-q923xxn2	258	41	critical	critical	JJ
cord-261532-q923xxn2	258	42	for	for	IN
cord-261532-q923xxn2	258	43	the	the	DT
cord-261532-q923xxn2	258	44	binding	binding	NN
cord-261532-q923xxn2	258	45	to	to	IN
cord-261532-q923xxn2	258	46	tyrosine	tyrosine	NN
cord-261532-q923xxn2	258	47	kinases	kinase	NNS
cord-261532-q923xxn2	258	48	of	of	IN
cord-261532-q923xxn2	258	49	JAK	JAK	NNP
cord-261532-q923xxn2	258	50	family	family	NN
cord-261532-q923xxn2	258	51	.	.	.
cord-261532-q923xxn2	259	1	IL-4	IL-4	NNP
cord-261532-q923xxn2	259	2	receptors	receptor	NNS
cord-261532-q923xxn2	259	3	consist	consist	VBP
cord-261532-q923xxn2	259	4	of	of	IN
cord-261532-q923xxn2	259	5	two	two	CD
cord-261532-q923xxn2	259	6	transmembrane	transmembrane	NN
cord-261532-q923xxn2	259	7	proteins	protein	NNS
cord-261532-q923xxn2	259	8	.	.	.
cord-261532-q923xxn2	260	1	In	in	IN
cord-261532-q923xxn2	260	2	hematopoietic	hematopoietic	JJ
cord-261532-q923xxn2	260	3	cells	cell	NNS
cord-261532-q923xxn2	260	4	,	,	,
cord-261532-q923xxn2	260	5	the	the	DT
cord-261532-q923xxn2	260	6	IL-4Rа	IL-4Rа	NNP
cord-261532-q923xxn2	260	7	chain	chain	NN
cord-261532-q923xxn2	260	8	binds	bind	VBZ
cord-261532-q923xxn2	260	9	to	to	IN
cord-261532-q923xxn2	260	10	a	a	DT
cord-261532-q923xxn2	260	11	common	common	JJ
cord-261532-q923xxn2	260	12	gamma	gamma	NN
cord-261532-q923xxn2	260	13	chain	chain	NN
cord-261532-q923xxn2	260	14	(	(	-LRB-
cord-261532-q923xxn2	260	15	γC	γc	NN
cord-261532-q923xxn2	260	16	)	)	-RRB-
cord-261532-q923xxn2	260	17	to	to	TO
cord-261532-q923xxn2	260	18	form	form	VB
cord-261532-q923xxn2	260	19	the	the	DT
cord-261532-q923xxn2	260	20	type	type	NN
cord-261532-q923xxn2	260	21	I	-PRON-	PRP
cord-261532-q923xxn2	260	22	IL-4R	il-4r	CD
cord-261532-q923xxn2	260	23	receptor	receptor	NN
cord-261532-q923xxn2	260	24	.	.	.
cord-261532-q923xxn2	261	1	Most	most	RBS
cord-261532-q923xxn2	261	2	notably	notably	RB
cord-261532-q923xxn2	261	3	,	,	,
cord-261532-q923xxn2	261	4	IL-4Rα	IL-4Rα	NNP
cord-261532-q923xxn2	261	5	chain	chain	NN
cord-261532-q923xxn2	261	6	has	have	VBZ
cord-261532-q923xxn2	261	7	high	high	JJ
cord-261532-q923xxn2	261	8	affinity	affinity	NN
cord-261532-q923xxn2	261	9	with	with	IN
cord-261532-q923xxn2	261	10	IL-4	IL-4	NNP
cord-261532-q923xxn2	261	11	,	,	,
cord-261532-q923xxn2	261	12	and	and	CC
cord-261532-q923xxn2	261	13	the	the	DT
cord-261532-q923xxn2	261	14	γC	γC	NNP
cord-261532-q923xxn2	261	15	chain	chain	NN
cord-261532-q923xxn2	261	16	is	be	VBZ
cord-261532-q923xxn2	261	17	also	also	RB
cord-261532-q923xxn2	261	18	a	a	DT
cord-261532-q923xxn2	261	19	component	component	NN
cord-261532-q923xxn2	261	20	of	of	IN
cord-261532-q923xxn2	261	21	the	the	DT
cord-261532-q923xxn2	261	22	receptors	receptor	NNS
cord-261532-q923xxn2	261	23	for	for	IN
cord-261532-q923xxn2	261	24	IL-2	IL-2	NNP
cord-261532-q923xxn2	261	25	,	,	,
cord-261532-q923xxn2	261	26	IL-7	IL-7	NNP
cord-261532-q923xxn2	261	27	,	,	,
cord-261532-q923xxn2	261	28	IL-9	IL-9	NNP
cord-261532-q923xxn2	261	29	,	,	,
cord-261532-q923xxn2	261	30	IL-15	IL-15	NNP
cord-261532-q923xxn2	261	31	and	and	CC
cord-261532-q923xxn2	261	32	IL-21	IL-21	NNP
cord-261532-q923xxn2	261	33	.	.	.
cord-261532-q923xxn2	262	1	In	in	IN
cord-261532-q923xxn2	262	2	nonhematopoietic	nonhematopoietic	JJ
cord-261532-q923xxn2	262	3	cells	cell	NNS
cord-261532-q923xxn2	262	4	,	,	,
cord-261532-q923xxn2	262	5	the	the	DT
cord-261532-q923xxn2	262	6	type	type	NN
cord-261532-q923xxn2	262	7	II	II	NNP
cord-261532-q923xxn2	262	8	IL-4	IL-4	NNP
cord-261532-q923xxn2	262	9	receptor	receptor	NN
cord-261532-q923xxn2	262	10	is	be	VBZ
cord-261532-q923xxn2	262	11	formed	form	VBN
cord-261532-q923xxn2	262	12	by	by	IN
cord-261532-q923xxn2	262	13	interaction	interaction	NN
cord-261532-q923xxn2	262	14	of	of	IN
cord-261532-q923xxn2	262	15	IL-4Rα	IL-4Rα	NNP
cord-261532-q923xxn2	262	16	with	with	IN
cord-261532-q923xxn2	262	17	IL-13Rα1	IL-13Rα1	NNP
cord-261532-q923xxn2	262	18	instead	instead	RB
cord-261532-q923xxn2	262	19	of	of	IN
cord-261532-q923xxn2	262	20	γC	γc	NN
cord-261532-q923xxn2	262	21	and	and	CC
cord-261532-q923xxn2	262	22	recognizes	recognize	VBZ
cord-261532-q923xxn2	262	23	both	both	CC
cord-261532-q923xxn2	262	24	IL-4	IL-4	NNP
cord-261532-q923xxn2	262	25	and	and	CC
cord-261532-q923xxn2	262	26	IL-13	IL-13	NNP
cord-261532-q923xxn2	262	27	.	.	.
cord-261532-q923xxn2	263	1	IL-13	IL-13	NNP
cord-261532-q923xxn2	263	2	binds	bind	VBZ
cord-261532-q923xxn2	263	3	to	to	IN
cord-261532-q923xxn2	263	4	IL-13Rα1	IL-13Rα1	NNP
cord-261532-q923xxn2	263	5	with	with	IN
cord-261532-q923xxn2	263	6	higher	high	JJR
cord-261532-q923xxn2	263	7	affinity	affinity	NN
cord-261532-q923xxn2	263	8	(	(	-LRB-
cord-261532-q923xxn2	263	9	Hebenstreit	Hebenstreit	NNP
cord-261532-q923xxn2	263	10	et	et	NNP
cord-261532-q923xxn2	263	11	al	al	NNP
cord-261532-q923xxn2	263	12	.	.	NNP
cord-261532-q923xxn2	263	13	,	,	,
cord-261532-q923xxn2	263	14	2006	2006	CD
cord-261532-q923xxn2	263	15	)	)	-RRB-
cord-261532-q923xxn2	263	16	.	.	.
cord-261532-q923xxn2	264	1	In	in	IN
cord-261532-q923xxn2	264	2	contrast	contrast	NN
cord-261532-q923xxn2	264	3	,	,	,
cord-261532-q923xxn2	264	4	IL-13α2	IL-13α2	NNP
cord-261532-q923xxn2	264	5	has	have	VBZ
cord-261532-q923xxn2	264	6	higher	high	JJR
cord-261532-q923xxn2	264	7	affinity	affinity	NN
cord-261532-q923xxn2	264	8	for	for	IN
cord-261532-q923xxn2	264	9	IL-13	IL-13	NNP
cord-261532-q923xxn2	264	10	but	but	CC
cord-261532-q923xxn2	264	11	fails	fail	VBZ
cord-261532-q923xxn2	264	12	to	to	TO
cord-261532-q923xxn2	264	13	induce	induce	VB
cord-261532-q923xxn2	264	14	a	a	DT
cord-261532-q923xxn2	264	15	signal	signal	NN
cord-261532-q923xxn2	264	16	,	,	,
cord-261532-q923xxn2	264	17	indicating	indicate	VBG
cord-261532-q923xxn2	264	18	that	that	IN
cord-261532-q923xxn2	264	19	IL-13α2	IL-13α2	NNP
cord-261532-q923xxn2	264	20	acts	act	VBZ
cord-261532-q923xxn2	264	21	as	as	IN
cord-261532-q923xxn2	264	22	a	a	DT
cord-261532-q923xxn2	264	23	decoy	decoy	NN
cord-261532-q923xxn2	264	24	receptor	receptor	NN
cord-261532-q923xxn2	264	25	.	.	.
cord-261532-q923xxn2	265	1	The	the	DT
cord-261532-q923xxn2	265	2	cytoplasmic	cytoplasmic	JJ
cord-261532-q923xxn2	265	3	tails	tail	NNS
cord-261532-q923xxn2	265	4	of	of	IN
cord-261532-q923xxn2	265	5	IL-4	IL-4	NNP
cord-261532-q923xxn2	265	6	/	/	SYM
cord-261532-q923xxn2	265	7	IL-13	IL-13	NNP
cord-261532-q923xxn2	265	8	receptor	receptor	NN
cord-261532-q923xxn2	265	9	subunits	subunit	NNS
cord-261532-q923xxn2	265	10	associate	associate	VBP
cord-261532-q923xxn2	265	11	with	with	IN
cord-261532-q923xxn2	265	12	tyrosine	tyrosine	NN
cord-261532-q923xxn2	265	13	kinase	kinase	NN
cord-261532-q923xxn2	265	14	of	of	IN
cord-261532-q923xxn2	265	15	the	the	DT
cord-261532-q923xxn2	265	16	Janus	Janus	NNP
cord-261532-q923xxn2	265	17	family	family	NN
cord-261532-q923xxn2	265	18	:	:	:
cord-261532-q923xxn2	265	19	IL-4Rα	il-4rα	PRP
cord-261532-q923xxn2	265	20	binds	bind	VBZ
cord-261532-q923xxn2	265	21	to	to	IN
cord-261532-q923xxn2	265	22	JAK1	JAK1	NNP
cord-261532-q923xxn2	265	23	,	,	,
cord-261532-q923xxn2	265	24	γC	γc	NN
cord-261532-q923xxn2	265	25	with	with	IN
cord-261532-q923xxn2	265	26	JAK3	JAK3	NNP
cord-261532-q923xxn2	265	27	whereas	whereas	IN
cord-261532-q923xxn2	265	28	IL-13Rα1	IL-13Rα1	NNP
cord-261532-q923xxn2	265	29	with	with	IN
cord-261532-q923xxn2	265	30	JAK2	JAK2	NNP
cord-261532-q923xxn2	265	31	or	or	CC
cord-261532-q923xxn2	265	32	TYK2	TYK2	NNP
cord-261532-q923xxn2	265	33	.	.	.
cord-261532-q923xxn2	266	1	Upon	upon	IN
cord-261532-q923xxn2	266	2	IL-4	IL-4	NNP
cord-261532-q923xxn2	266	3	/	/	SYM
cord-261532-q923xxn2	266	4	IL-13	IL-13	NNP
cord-261532-q923xxn2	266	5	binding	binding	NN
cord-261532-q923xxn2	266	6	,	,	,
cord-261532-q923xxn2	266	7	heterodimerized	heterodimerized	JJ
cord-261532-q923xxn2	266	8	receptors	receptor	NNS
cord-261532-q923xxn2	266	9	activate	activate	VBP
cord-261532-q923xxn2	266	10	JAKs	jak	NNS
cord-261532-q923xxn2	266	11	.	.	.
cord-261532-q923xxn2	267	1	Subsequently	subsequently	RB
cord-261532-q923xxn2	267	2	,	,	,
cord-261532-q923xxn2	267	3	JAKs	jak	NNS
cord-261532-q923xxn2	267	4	phosphorylate	phosphorylate	VBP
cord-261532-q923xxn2	267	5	three	three	CD
cord-261532-q923xxn2	267	6	core	core	NN
cord-261532-q923xxn2	267	7	tyrosine	tyrosine	NN
cord-261532-q923xxn2	267	8	residues	residue	NNS
cord-261532-q923xxn2	267	9	(	(	-LRB-
cord-261532-q923xxn2	267	10	Y	Y	NNP
cord-261532-q923xxn2	267	11	575	575	CD
cord-261532-q923xxn2	267	12	,	,	,
cord-261532-q923xxn2	267	13	Y	Y	NNP
cord-261532-q923xxn2	267	14	603	603	CD
cord-261532-q923xxn2	267	15	and	and	CC
cord-261532-q923xxn2	267	16	Y	Y	NNP
cord-261532-q923xxn2	267	17	631	631	CD
cord-261532-q923xxn2	267	18	)	)	-RRB-
cord-261532-q923xxn2	267	19	in	in	IN
cord-261532-q923xxn2	267	20	IL-4Rα	IL-4Rα	NNP
cord-261532-q923xxn2	267	21	,	,	,
cord-261532-q923xxn2	267	22	providing	provide	VBG
cord-261532-q923xxn2	267	23	the	the	DT
cord-261532-q923xxn2	267	24	docking	docking	NN
cord-261532-q923xxn2	267	25	sites	site	NNS
cord-261532-q923xxn2	267	26	for	for	IN
cord-261532-q923xxn2	267	27	STAT6	STAT6	NNS
cord-261532-q923xxn2	267	28	.	.	.
cord-261532-q923xxn2	268	1	Intriguingly	intriguingly	RB
cord-261532-q923xxn2	268	2	,	,	,
cord-261532-q923xxn2	268	3	any	any	DT
cord-261532-q923xxn2	268	4	one	one	CD
cord-261532-q923xxn2	268	5	of	of	IN
cord-261532-q923xxn2	268	6	the	the	DT
cord-261532-q923xxn2	268	7	three	three	CD
cord-261532-q923xxn2	268	8	tyrosine	tyrosine	NN
cord-261532-q923xxn2	268	9	residues	residue	NNS
cord-261532-q923xxn2	268	10	is	be	VBZ
cord-261532-q923xxn2	268	11	competent	competent	JJ
cord-261532-q923xxn2	268	12	to	to	TO
cord-261532-q923xxn2	268	13	activate	activate	VB
cord-261532-q923xxn2	268	14	STAT6	STAT6	NNS
cord-261532-q923xxn2	268	15	.	.	.
cord-261532-q923xxn2	269	1	Then	then	RB
cord-261532-q923xxn2	269	2	JAKs	jak	NNS
cord-261532-q923xxn2	269	3	further	further	RB
cord-261532-q923xxn2	269	4	phosphorylate	phosphorylate	VB
cord-261532-q923xxn2	269	5	STAT6	stat6	NN
cord-261532-q923xxn2	269	6	at	at	IN
cord-261532-q923xxn2	269	7	the	the	DT
cord-261532-q923xxn2	269	8	receptor	receptor	NN
cord-261532-q923xxn2	269	9	:	:	:
cord-261532-q923xxn2	270	1	activated	activate	VBN
cord-261532-q923xxn2	270	2	STAT6	STAT6	NNP
cord-261532-q923xxn2	270	3	dimerizes	dimerize	NNS
cord-261532-q923xxn2	270	4	through	through	IN
cord-261532-q923xxn2	270	5	SH2	SH2	NNP
cord-261532-q923xxn2	270	6	domain	domain	NN
cord-261532-q923xxn2	270	7	and	and	CC
cord-261532-q923xxn2	270	8	translocates	translocate	NNS
cord-261532-q923xxn2	270	9	into	into	IN
cord-261532-q923xxn2	270	10	nucleus	nucleus	NN
cord-261532-q923xxn2	270	11	to	to	TO
cord-261532-q923xxn2	270	12	function	function	VB
cord-261532-q923xxn2	270	13	as	as	IN
cord-261532-q923xxn2	270	14	a	a	DT
cord-261532-q923xxn2	270	15	transcriptional	transcriptional	JJ
cord-261532-q923xxn2	270	16	factor	factor	NN
cord-261532-q923xxn2	270	17	,	,	,
cord-261532-q923xxn2	270	18	regulating	regulate	VBG
cord-261532-q923xxn2	270	19	IL-4	IL-4	NNP
cord-261532-q923xxn2	270	20	/	/	SYM
cord-261532-q923xxn2	270	21	IL-13-dependent	il-13-dependent	NN
cord-261532-q923xxn2	270	22	signaling	signal	VBG
cord-261532-q923xxn2	270	23	such	such	JJ
cord-261532-q923xxn2	270	24	as	as	IN
cord-261532-q923xxn2	270	25	Th2	th2	CD
cord-261532-q923xxn2	270	26	differentiation	differentiation	NN
cord-261532-q923xxn2	270	27	,	,	,
cord-261532-q923xxn2	270	28	immunoglobulin	immunoglobulin	NN
cord-261532-q923xxn2	270	29	E	E	NNP
cord-261532-q923xxn2	270	30	(	(	-LRB-
cord-261532-q923xxn2	270	31	IgE	IgE	NNP
cord-261532-q923xxn2	270	32	)	)	-RRB-
cord-261532-q923xxn2	270	33	and	and	CC
cord-261532-q923xxn2	270	34	chemokine	chemokine	NN
cord-261532-q923xxn2	270	35	production	production	NN
cord-261532-q923xxn2	270	36	and	and	CC
cord-261532-q923xxn2	270	37	mucus	mucus	NN
cord-261532-q923xxn2	270	38	generation	generation	NN
cord-261532-q923xxn2	270	39	.	.	.
cord-261532-q923xxn2	271	1	STAT6	STAT6	NNP
cord-261532-q923xxn2	271	2	prefers	prefer	VBZ
cord-261532-q923xxn2	271	3	sites	site	NNS
cord-261532-q923xxn2	271	4	with	with	IN
cord-261532-q923xxn2	271	5	a	a	DT
cord-261532-q923xxn2	271	6	4-bp	4-bp	CD
cord-261532-q923xxn2	271	7	spacer	spacer	NN
cord-261532-q923xxn2	271	8	(	(	-LRB-
cord-261532-q923xxn2	271	9	TTCNNNNGAA	TTCNNNNGAA	NNP
cord-261532-q923xxn2	271	10	,	,	,
cord-261532-q923xxn2	271	11	the	the	DT
cord-261532-q923xxn2	271	12	N4	N4	NNP
cord-261532-q923xxn2	271	13	site	site	NN
cord-261532-q923xxn2	271	14	)	)	-RRB-
cord-261532-q923xxn2	271	15	,	,	,
cord-261532-q923xxn2	271	16	which	which	WDT
cord-261532-q923xxn2	271	17	are	be	VBP
cord-261532-q923xxn2	271	18	mainly	mainly	RB
cord-261532-q923xxn2	271	19	found	find	VBN
cord-261532-q923xxn2	271	20	in	in	IN
cord-261532-q923xxn2	271	21	IL-4	IL-4	NNP
cord-261532-q923xxn2	271	22	responsive	responsive	JJ
cord-261532-q923xxn2	271	23	promoters	promoter	NNS
cord-261532-q923xxn2	271	24	.	.	.
cord-261532-q923xxn2	272	1	It	-PRON-	PRP
cord-261532-q923xxn2	272	2	is	be	VBZ
cord-261532-q923xxn2	272	3	notable	notable	JJ
cord-261532-q923xxn2	272	4	that	that	IN
cord-261532-q923xxn2	272	5	the	the	DT
cord-261532-q923xxn2	272	6	activation	activation	NN
cord-261532-q923xxn2	272	7	of	of	IN
cord-261532-q923xxn2	272	8	STAT6	stat6	NN
cord-261532-q923xxn2	272	9	by	by	IN
cord-261532-q923xxn2	272	10	cytokines	cytokine	NNS
cord-261532-q923xxn2	272	11	is	be	VBZ
cord-261532-q923xxn2	272	12	very	very	RB
cord-261532-q923xxn2	272	13	transient	transient	JJ
cord-261532-q923xxn2	272	14	,	,	,
cord-261532-q923xxn2	272	15	peaking	peak	VBG
cord-261532-q923xxn2	272	16	at	at	IN
cord-261532-q923xxn2	272	17	10	10	CD
cord-261532-q923xxn2	272	18	-	-	SYM
cord-261532-q923xxn2	272	19	30	30	CD
cord-261532-q923xxn2	272	20	min	min	NN
cord-261532-q923xxn2	272	21	,	,	,
cord-261532-q923xxn2	272	22	and	and	CC
cord-261532-q923xxn2	272	23	nearly	nearly	RB
cord-261532-q923xxn2	272	24	undetectable	undetectable	JJ
cord-261532-q923xxn2	272	25	after	after	IN
cord-261532-q923xxn2	272	26	4	4	CD
cord-261532-q923xxn2	272	27	h	h	NN
cord-261532-q923xxn2	272	28	,	,	,
cord-261532-q923xxn2	272	29	indicating	indicate	VBG
cord-261532-q923xxn2	272	30	a	a	DT
cord-261532-q923xxn2	272	31	quick	quick	JJ
cord-261532-q923xxn2	272	32	downregulating	downregulating	NN
cord-261532-q923xxn2	272	33	mechanism	mechanism	NN
cord-261532-q923xxn2	272	34	.	.	.
cord-261532-q923xxn2	273	1	It	-PRON-	PRP
cord-261532-q923xxn2	273	2	is	be	VBZ
cord-261532-q923xxn2	273	3	reported	report	VBN
cord-261532-q923xxn2	273	4	that	that	IN
cord-261532-q923xxn2	273	5	tyrosine	tyrosine	NN
cord-261532-q923xxn2	273	6	phosphatase	phosphatase	NN
cord-261532-q923xxn2	273	7	Shp-1	Shp-1	NNP
cord-261532-q923xxn2	273	8	is	be	VBZ
cord-261532-q923xxn2	273	9	involved	involve	VBN
cord-261532-q923xxn2	273	10	in	in	IN
cord-261532-q923xxn2	273	11	this	this	DT
cord-261532-q923xxn2	273	12	dephosphorylating	dephosphorylating	NN
cord-261532-q923xxn2	273	13	process	process	NN
cord-261532-q923xxn2	273	14	.	.	.
cord-261532-q923xxn2	274	1	Other	other	JJ
cord-261532-q923xxn2	274	2	studies	study	NNS
cord-261532-q923xxn2	274	3	also	also	RB
cord-261532-q923xxn2	274	4	indicate	indicate	VBP
cord-261532-q923xxn2	274	5	that	that	IN
cord-261532-q923xxn2	274	6	STAT6	stat6	NN
cord-261532-q923xxn2	274	7	induces	induce	VBZ
cord-261532-q923xxn2	274	8	the	the	DT
cord-261532-q923xxn2	274	9	expression	expression	NN
cord-261532-q923xxn2	274	10	of	of	IN
cord-261532-q923xxn2	274	11	some	some	DT
cord-261532-q923xxn2	274	12	negative	negative	JJ
cord-261532-q923xxn2	274	13	regulators	regulator	NNS
cord-261532-q923xxn2	274	14	such	such	JJ
cord-261532-q923xxn2	274	15	as	as	IN
cord-261532-q923xxn2	274	16	the	the	DT
cord-261532-q923xxn2	274	17	suppressor	suppressor	NN
cord-261532-q923xxn2	274	18	of	of	IN
cord-261532-q923xxn2	274	19	cytokine	cytokine	NN
cord-261532-q923xxn2	274	20	signaling	signaling	NN
cord-261532-q923xxn2	274	21	(	(	-LRB-
cord-261532-q923xxn2	274	22	SOCS	SOCS	NNP
cord-261532-q923xxn2	274	23	)	)	-RRB-
cord-261532-q923xxn2	274	24	.	.	.
cord-261532-q923xxn2	275	1	Besides	besides	IN
cord-261532-q923xxn2	275	2	IL-4	IL-4	NNP
cord-261532-q923xxn2	275	3	/	/	SYM
cord-261532-q923xxn2	275	4	IL-13	IL-13	NNP
cord-261532-q923xxn2	275	5	,	,	,
cord-261532-q923xxn2	275	6	many	many	JJ
cord-261532-q923xxn2	275	7	other	other	JJ
cord-261532-q923xxn2	275	8	cytokines	cytokine	NNS
cord-261532-q923xxn2	275	9	have	have	VBP
cord-261532-q923xxn2	275	10	been	be	VBN
cord-261532-q923xxn2	275	11	reported	report	VBN
cord-261532-q923xxn2	275	12	to	to	TO
cord-261532-q923xxn2	275	13	activate	activate	VB
cord-261532-q923xxn2	275	14	STAT6	STAT6	NNS
cord-261532-q923xxn2	275	15	in	in	IN
cord-261532-q923xxn2	275	16	a	a	DT
cord-261532-q923xxn2	275	17	similar	similar	JJ
cord-261532-q923xxn2	275	18	way	way	NN
cord-261532-q923xxn2	275	19	.	.	.
cord-261532-q923xxn2	276	1	IL-3	IL-3	NNP
cord-261532-q923xxn2	276	2	affects	affect	VBZ
cord-261532-q923xxn2	276	3	the	the	DT
cord-261532-q923xxn2	276	4	proliferation	proliferation	NN
cord-261532-q923xxn2	276	5	of	of	IN
cord-261532-q923xxn2	276	6	hematopoietic	hematopoietic	JJ
cord-261532-q923xxn2	276	7	cells	cell	NNS
cord-261532-q923xxn2	276	8	via	via	IN
cord-261532-q923xxn2	276	9	tyrosine	tyrosine	NN
cord-261532-q923xxn2	276	10	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	276	11	of	of	IN
cord-261532-q923xxn2	276	12	STAT6	STAT6	NNS
cord-261532-q923xxn2	276	13	.	.	.
cord-261532-q923xxn2	277	1	IL-15	IL-15	NNP
cord-261532-q923xxn2	277	2	activates	activate	VBZ
cord-261532-q923xxn2	277	3	STAT6	STAT6	NNS
cord-261532-q923xxn2	277	4	in	in	IN
cord-261532-q923xxn2	277	5	different	different	JJ
cord-261532-q923xxn2	277	6	cells	cell	NNS
cord-261532-q923xxn2	277	7	including	include	VBG
cord-261532-q923xxn2	277	8	T	t	NN
cord-261532-q923xxn2	277	9	cell	cell	NN
cord-261532-q923xxn2	277	10	,	,	,
cord-261532-q923xxn2	277	11	NK	NK	NNP
cord-261532-q923xxn2	277	12	cell	cell	NN
cord-261532-q923xxn2	277	13	,	,	,
cord-261532-q923xxn2	277	14	and	and	CC
cord-261532-q923xxn2	277	15	mast	mast	NN
cord-261532-q923xxn2	277	16	cell	cell	NN
cord-261532-q923xxn2	277	17	to	to	TO
cord-261532-q923xxn2	277	18	initiate	initiate	VB
cord-261532-q923xxn2	277	19	the	the	DT
cord-261532-q923xxn2	277	20	expression	expression	NN
cord-261532-q923xxn2	277	21	of	of	IN
cord-261532-q923xxn2	277	22	anti	anti	JJ
cord-261532-q923xxn2	277	23	-	-	JJ
cord-261532-q923xxn2	277	24	apoptosis	apoptosis	JJ
cord-261532-q923xxn2	277	25	genes	gene	NNS
cord-261532-q923xxn2	277	26	like	like	IN
cord-261532-q923xxn2	277	27	Bcl	Bcl	NNP
cord-261532-q923xxn2	277	28	-	-	HYPH
cord-261532-q923xxn2	277	29	xL.	xL.	NNP
cord-261532-q923xxn2	278	1	In	in	IN
cord-261532-q923xxn2	278	2	some	some	DT
cord-261532-q923xxn2	278	3	B	b	NN
cord-261532-q923xxn2	278	4	cell	cell	NN
cord-261532-q923xxn2	278	5	lines	line	NNS
cord-261532-q923xxn2	278	6	,	,	,
cord-261532-q923xxn2	278	7	IFN	IFN	NNP
cord-261532-q923xxn2	278	8	-	-	HYPH
cord-261532-q923xxn2	278	9	α	α	NNP
cord-261532-q923xxn2	278	10	was	be	VBD
cord-261532-q923xxn2	278	11	found	find	VBN
cord-261532-q923xxn2	278	12	to	to	TO
cord-261532-q923xxn2	278	13	activate	activate	VB
cord-261532-q923xxn2	278	14	STAT6	STAT6	NNS
cord-261532-q923xxn2	278	15	,	,	,
cord-261532-q923xxn2	278	16	which	which	WDT
cord-261532-q923xxn2	278	17	can	can	MD
cord-261532-q923xxn2	278	18	even	even	RB
cord-261532-q923xxn2	278	19	lead	lead	VB
cord-261532-q923xxn2	278	20	to	to	IN
cord-261532-q923xxn2	278	21	the	the	DT
cord-261532-q923xxn2	278	22	formation	formation	NN
cord-261532-q923xxn2	278	23	of	of	IN
cord-261532-q923xxn2	278	24	STAT2	STAT2	NNS
cord-261532-q923xxn2	278	25	/	/	SYM
cord-261532-q923xxn2	278	26	STAT6	stat6	NN
cord-261532-q923xxn2	278	27	heterodimer	heterodimer	NN
cord-261532-q923xxn2	278	28	.	.	.
cord-261532-q923xxn2	279	1	In	in	IN
cord-261532-q923xxn2	279	2	addition	addition	NN
cord-261532-q923xxn2	279	3	,	,	,
cord-261532-q923xxn2	279	4	platelet	platelet	NN
cord-261532-q923xxn2	279	5	-	-	HYPH
cord-261532-q923xxn2	279	6	derived	derive	VBN
cord-261532-q923xxn2	279	7	growth	growth	NN
cord-261532-q923xxn2	279	8	factor	factor	NN
cord-261532-q923xxn2	279	9	(	(	-LRB-
cord-261532-q923xxn2	279	10	PDGF	PDGF	NNP
cord-261532-q923xxn2	279	11	)	)	-RRB-
cord-261532-q923xxn2	279	12	,	,	,
cord-261532-q923xxn2	279	13	a	a	DT
cord-261532-q923xxn2	279	14	major	major	JJ
cord-261532-q923xxn2	279	15	mitogen	mitogen	NN
cord-261532-q923xxn2	279	16	and	and	CC
cord-261532-q923xxn2	279	17	chemotactic	chemotactic	JJ
cord-261532-q923xxn2	279	18	factor	factor	NN
cord-261532-q923xxn2	279	19	for	for	IN
cord-261532-q923xxn2	279	20	mesenchymal	mesenchymal	JJ
cord-261532-q923xxn2	279	21	cells	cell	NNS
cord-261532-q923xxn2	279	22	such	such	JJ
cord-261532-q923xxn2	279	23	as	as	IN
cord-261532-q923xxn2	279	24	fibroblasts	fibroblast	NNS
cord-261532-q923xxn2	279	25	and	and	CC
cord-261532-q923xxn2	279	26	smooth	smooth	JJ
cord-261532-q923xxn2	279	27	muscle	muscle	NN
cord-261532-q923xxn2	279	28	cells	cell	NNS
cord-261532-q923xxn2	279	29	,	,	,
cord-261532-q923xxn2	279	30	also	also	RB
cord-261532-q923xxn2	279	31	exerts	exert	VBZ
cord-261532-q923xxn2	279	32	an	an	DT
cord-261532-q923xxn2	279	33	effect	effect	NN
cord-261532-q923xxn2	279	34	on	on	IN
cord-261532-q923xxn2	279	35	JAK	JAK	NNP
cord-261532-q923xxn2	279	36	-	-	HYPH
cord-261532-q923xxn2	279	37	mediated	mediate	VBN
cord-261532-q923xxn2	279	38	STAT6	stat6	NN
cord-261532-q923xxn2	279	39	activation	activation	NN
cord-261532-q923xxn2	279	40	in	in	IN
cord-261532-q923xxn2	279	41	NIH	NIH	NNP
cord-261532-q923xxn2	279	42	3T3	3t3	CD
cord-261532-q923xxn2	279	43	fibroblasts	fibroblast	NNS
cord-261532-q923xxn2	279	44	and	and	CC
cord-261532-q923xxn2	279	45	3T3-L1	3t3-l1	CD
cord-261532-q923xxn2	279	46	preadipocytes	preadipocyte	NNS
cord-261532-q923xxn2	279	47	.	.	.
cord-261532-q923xxn2	280	1	On	on	IN
cord-261532-q923xxn2	280	2	the	the	DT
cord-261532-q923xxn2	280	3	contrary	contrary	NN
cord-261532-q923xxn2	280	4	,	,	,
cord-261532-q923xxn2	280	5	experiments	experiment	NNS
cord-261532-q923xxn2	280	6	using	use	VBG
cord-261532-q923xxn2	280	7	fibroblasts	fibroblast	NNS
cord-261532-q923xxn2	280	8	derived	derive	VBN
cord-261532-q923xxn2	280	9	from	from	IN
cord-261532-q923xxn2	280	10	STAT6	stat6	NN
cord-261532-q923xxn2	280	11	knockout	knockout	NN
cord-261532-q923xxn2	280	12	mice	mouse	NNS
cord-261532-q923xxn2	280	13	do	do	VBP
cord-261532-q923xxn2	280	14	not	not	RB
cord-261532-q923xxn2	280	15	support	support	VB
cord-261532-q923xxn2	280	16	any	any	DT
cord-261532-q923xxn2	280	17	dependence	dependence	NN
cord-261532-q923xxn2	280	18	of	of	IN
cord-261532-q923xxn2	280	19	STAT6	stat6	NN
cord-261532-q923xxn2	280	20	on	on	IN
cord-261532-q923xxn2	280	21	PDGF	PDGF	NNP
cord-261532-q923xxn2	280	22	.	.	.
cord-261532-q923xxn2	281	1	Researches	research	NNS
cord-261532-q923xxn2	281	2	on	on	IN
cord-261532-q923xxn2	281	3	murine	murine	JJ
cord-261532-q923xxn2	281	4	mastocytes	mastocyte	NNS
cord-261532-q923xxn2	281	5	demonstrate	demonstrate	VBP
cord-261532-q923xxn2	281	6	that	that	IN
cord-261532-q923xxn2	281	7	IL-15	IL-15	NNP
cord-261532-q923xxn2	281	8	induces	induce	VBZ
cord-261532-q923xxn2	281	9	TYK2-mediated	tyk2-mediate	VBN
cord-261532-q923xxn2	281	10	STAT6	STAT6	NNP
cord-261532-q923xxn2	281	11	activation	activation	NN
cord-261532-q923xxn2	282	1	consequently	consequently	RB
cord-261532-q923xxn2	282	2	s	s	VBZ
cord-261532-q923xxn2	283	1	u	u	NN
cord-261532-q923xxn2	283	2	p	p	NN
cord-261532-q923xxn2	283	3	p	p	NN
cord-261532-q923xxn2	283	4	r	r	NN
cord-261532-q923xxn2	283	5	e	e	NN
cord-261532-q923xxn2	283	6	s	s	NN
cord-261532-q923xxn2	283	7	s	s	NN
cord-261532-q923xxn2	284	1	i	i	PRP
cord-261532-q923xxn2	285	1	n	n	CC
cord-261532-q923xxn2	285	2	g	g	NNP
cord-261532-q923xxn2	285	3	t	t	NN
cord-261532-q923xxn2	286	1	h	h	NN
cord-261532-q923xxn2	286	2	e	e	NN
cord-261532-q923xxn2	286	3	a	a	NN
cord-261532-q923xxn2	287	1	p	p	NN
cord-261532-q923xxn2	287	2	o	o	NN
cord-261532-q923xxn2	287	3	p	p	NN
cord-261532-q923xxn2	288	1	t	t	NNP
cord-261532-q923xxn2	288	2	o	o	NNP
cord-261532-q923xxn2	289	1	s	s	NNP
cord-261532-q923xxn2	290	1	i	i	PRP
cord-261532-q923xxn2	290	2	s	s	NNP
cord-261532-q923xxn2	291	1	i	i	PRP
cord-261532-q923xxn2	292	1	n	n	CC
cord-261532-q923xxn2	292	2	m	m	NNP
cord-261532-q923xxn2	292	3	a	a	NNP
cord-261532-q923xxn2	292	4	s	s	NN
cord-261532-q923xxn2	293	1	t	t	NNP
cord-261532-q923xxn2	293	2	o	o	NNP
cord-261532-q923xxn2	294	1	c	c	NNP
cord-261532-q923xxn2	294	2	y	y	NNP
cord-261532-q923xxn2	294	3	t	t	NNP
cord-261532-q923xxn2	294	4	e	e	NNP
cord-261532-q923xxn2	294	5	s	s	NNP
cord-261532-q923xxn2	294	6	.	.	.
cord-261532-q923xxn2	295	1	Upon	upon	IN
cord-261532-q923xxn2	295	2	binding	bind	VBG
cord-261532-q923xxn2	295	3	to	to	IN
cord-261532-q923xxn2	295	4	IL-4	IL-4	NNP
cord-261532-q923xxn2	295	5	/	/	SYM
cord-261532-q923xxn2	295	6	IL-13	IL-13	NNP
cord-261532-q923xxn2	295	7	,	,	,
cord-261532-q923xxn2	295	8	JAKs	jak	NNS
cord-261532-q923xxn2	295	9	located	locate	VBN
cord-261532-q923xxn2	295	10	in	in	IN
cord-261532-q923xxn2	295	11	the	the	DT
cord-261532-q923xxn2	295	12	C	C	NNP
cord-261532-q923xxn2	295	13	terminal	terminal	NN
cord-261532-q923xxn2	295	14	of	of	IN
cord-261532-q923xxn2	295	15	IL-4Rα	IL-4Rα	NNP
cord-261532-q923xxn2	295	16	is	be	VBZ
cord-261532-q923xxn2	295	17	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	295	18	and	and	CC
cord-261532-q923xxn2	295	19	activated	activate	VBN
cord-261532-q923xxn2	295	20	.	.	.
cord-261532-q923xxn2	296	1	Sequentially	sequentially	RB
cord-261532-q923xxn2	296	2	,	,	,
cord-261532-q923xxn2	296	3	JAKs	jak	NNS
cord-261532-q923xxn2	296	4	phophorylate	phophorylate	NNP
cord-261532-q923xxn2	296	5	three	three	CD
cord-261532-q923xxn2	296	6	tyrosine	tyrosine	NN
cord-261532-q923xxn2	296	7	residues	residue	NNS
cord-261532-q923xxn2	296	8	of	of	IN
cord-261532-q923xxn2	296	9	the	the	DT
cord-261532-q923xxn2	296	10	receptors	receptor	NNS
cord-261532-q923xxn2	296	11	,	,	,
cord-261532-q923xxn2	296	12	which	which	WDT
cord-261532-q923xxn2	296	13	provide	provide	VBP
cord-261532-q923xxn2	296	14	docking	docking	NN
cord-261532-q923xxn2	296	15	sites	site	NNS
cord-261532-q923xxn2	296	16	for	for	IN
cord-261532-q923xxn2	296	17	STAT6	STAT6	NNS
cord-261532-q923xxn2	296	18	.	.	.
cord-261532-q923xxn2	297	1	Afterwards	afterwards	RB
cord-261532-q923xxn2	297	2	,	,	,
cord-261532-q923xxn2	297	3	STAT6	STAT6	NNP
cord-261532-q923xxn2	297	4	is	be	VBZ
cord-261532-q923xxn2	297	5	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	297	6	by	by	IN
cord-261532-q923xxn2	297	7	JAKs	jak	NNS
cord-261532-q923xxn2	297	8	,	,	,
cord-261532-q923xxn2	297	9	leading	lead	VBG
cord-261532-q923xxn2	297	10	to	to	IN
cord-261532-q923xxn2	297	11	the	the	DT
cord-261532-q923xxn2	297	12	dimerization	dimerization	NN
cord-261532-q923xxn2	297	13	and	and	CC
cord-261532-q923xxn2	297	14	nuclear	nuclear	JJ
cord-261532-q923xxn2	297	15	translocation	translocation	NN
cord-261532-q923xxn2	297	16	to	to	TO
cord-261532-q923xxn2	297	17	induce	induce	VB
cord-261532-q923xxn2	297	18	the	the	DT
cord-261532-q923xxn2	297	19	expression	expression	NN
cord-261532-q923xxn2	297	20	of	of	IN
cord-261532-q923xxn2	297	21	genes	gene	NNS
cord-261532-q923xxn2	297	22	related	relate	VBN
cord-261532-q923xxn2	297	23	to	to	IN
cord-261532-q923xxn2	297	24	Th2	th2	CD
cord-261532-q923xxn2	297	25	differentiation	differentiation	NN
cord-261532-q923xxn2	297	26	.	.	.
cord-261532-q923xxn2	298	1	Left	leave	VBN
cord-261532-q923xxn2	298	2	:	:	:
cord-261532-q923xxn2	299	1	The	the	DT
cord-261532-q923xxn2	299	2	STAT6-dependent	stat6-dependent	CD
cord-261532-q923xxn2	299	3	antiviral	antiviral	JJ
cord-261532-q923xxn2	299	4	signaling	signal	VBG
cord-261532-q923xxn2	299	5	pathways	pathway	NNS
cord-261532-q923xxn2	299	6	.	.	.
cord-261532-q923xxn2	300	1	Upon	upon	IN
cord-261532-q923xxn2	300	2	DNA	dna	NN
cord-261532-q923xxn2	300	3	virus	virus	NN
cord-261532-q923xxn2	300	4	infection	infection	NN
cord-261532-q923xxn2	300	5	,	,	,
cord-261532-q923xxn2	300	6	activated	activate	VBN
cord-261532-q923xxn2	300	7	STING	sting	NN
cord-261532-q923xxn2	300	8	recruits	recruit	VBZ
cord-261532-q923xxn2	300	9	STAT6	stat6	XX
cord-261532-q923xxn2	300	10	.	.	.
cord-261532-q923xxn2	301	1	TBK1	TBK1	NNP
cord-261532-q923xxn2	301	2	is	be	VBZ
cord-261532-q923xxn2	301	3	also	also	RB
cord-261532-q923xxn2	301	4	recruited	recruit	VBN
cord-261532-q923xxn2	301	5	by	by	IN
cord-261532-q923xxn2	301	6	STING	sting	NN
cord-261532-q923xxn2	301	7	to	to	TO
cord-261532-q923xxn2	301	8	phosphorylate	phosphorylate	VB
cord-261532-q923xxn2	301	9	STAT6	stat6	NN
cord-261532-q923xxn2	301	10	on	on	IN
cord-261532-q923xxn2	301	11	S	S	NNP
cord-261532-q923xxn2	301	12	407	407	CD
cord-261532-q923xxn2	301	13	,	,	,
cord-261532-q923xxn2	301	14	which	which	WDT
cord-261532-q923xxn2	301	15	in	in	IN
cord-261532-q923xxn2	301	16	turn	turn	NN
cord-261532-q923xxn2	301	17	activates	activate	VBZ
cord-261532-q923xxn2	301	18	another	another	DT
cord-261532-q923xxn2	301	19	unidentified	unidentified	JJ
cord-261532-q923xxn2	301	20	tyrosine	tyrosine	NN
cord-261532-q923xxn2	301	21	kinase	kinase	NN
cord-261532-q923xxn2	301	22	to	to	TO
cord-261532-q923xxn2	301	23	phosphorylate	phosphorylate	VB
cord-261532-q923xxn2	301	24	STAT6	stat6	NN
cord-261532-q923xxn2	301	25	on	on	IN
cord-261532-q923xxn2	301	26	Y	Y	NNP
cord-261532-q923xxn2	301	27	641	641	CD
cord-261532-q923xxn2	301	28	,	,	,
cord-261532-q923xxn2	301	29	leading	lead	VBG
cord-261532-q923xxn2	301	30	to	to	IN
cord-261532-q923xxn2	301	31	the	the	DT
cord-261532-q923xxn2	301	32	homodimerization	homodimerization	NN
cord-261532-q923xxn2	301	33	and	and	CC
cord-261532-q923xxn2	301	34	nuclear	nuclear	JJ
cord-261532-q923xxn2	301	35	translocation	translocation	NN
cord-261532-q923xxn2	301	36	of	of	IN
cord-261532-q923xxn2	301	37	STAT6	STAT6	NNS
cord-261532-q923xxn2	301	38	.	.	.
cord-261532-q923xxn2	302	1	STAT6	stat6	NN
cord-261532-q923xxn2	302	2	dimer	dimer	NN
cord-261532-q923xxn2	302	3	then	then	RB
cord-261532-q923xxn2	302	4	binds	bind	VBZ
cord-261532-q923xxn2	302	5	to	to	IN
cord-261532-q923xxn2	302	6	its	-PRON-	PRP$
cord-261532-q923xxn2	302	7	target	target	NN
cord-261532-q923xxn2	302	8	sites	site	NNS
cord-261532-q923xxn2	302	9	to	to	TO
cord-261532-q923xxn2	302	10	initiate	initiate	VB
cord-261532-q923xxn2	302	11	transcription	transcription	NN
cord-261532-q923xxn2	302	12	.	.	.
cord-261532-q923xxn2	303	1	On	on	IN
cord-261532-q923xxn2	303	2	the	the	DT
cord-261532-q923xxn2	303	3	other	other	JJ
cord-261532-q923xxn2	303	4	hand	hand	NN
cord-261532-q923xxn2	303	5	,	,	,
cord-261532-q923xxn2	303	6	RNA	RNA	NNP
cord-261532-q923xxn2	303	7	virus	virus	NN
cord-261532-q923xxn2	303	8	infection	infection	NN
cord-261532-q923xxn2	303	9	triggers	trigger	VBZ
cord-261532-q923xxn2	303	10	STING	sting	VBP
cord-261532-q923xxn2	303	11	activation	activation	NN
cord-261532-q923xxn2	303	12	through	through	IN
cord-261532-q923xxn2	303	13	STING	sting	NN
cord-261532-q923xxn2	303	14	-	-	HYPH
cord-261532-q923xxn2	303	15	MAVS	mavs	RB
cord-261532-q923xxn2	303	16	interaction	interaction	NN
cord-261532-q923xxn2	303	17	on	on	IN
cord-261532-q923xxn2	303	18	MAVS	MAVS	NNP
cord-261532-q923xxn2	303	19	-	-	HYPH
cord-261532-q923xxn2	303	20	resident	resident	NN
cord-261532-q923xxn2	303	21	MAM	MAM	NNP
cord-261532-q923xxn2	303	22	or	or	CC
cord-261532-q923xxn2	303	23	peroxisomal	peroxisomal	JJ
cord-261532-q923xxn2	303	24	(	(	-LRB-
cord-261532-q923xxn2	303	25	Pex	Pex	NNP
cord-261532-q923xxn2	303	26	)	)	-RRB-
cord-261532-q923xxn2	303	27	membrane	membrane	NN
cord-261532-q923xxn2	303	28	;	;	,
cord-261532-q923xxn2	303	29	activated	activate	VBN
cord-261532-q923xxn2	303	30	STING	sting	NN
cord-261532-q923xxn2	303	31	then	then	RB
cord-261532-q923xxn2	303	32	dissociates	dissociate	VBZ
cord-261532-q923xxn2	303	33	with	with	IN
cord-261532-q923xxn2	303	34	MAVS	MAVS	NNPS
cord-261532-q923xxn2	303	35	and	and	CC
cord-261532-q923xxn2	303	36	recruits	recruit	VBZ
cord-261532-q923xxn2	303	37	STAT6	STAT6	NNS
cord-261532-q923xxn2	303	38	and	and	CC
cord-261532-q923xxn2	303	39	TBK1	TBK1	NNP
cord-261532-q923xxn2	303	40	,	,	,
cord-261532-q923xxn2	303	41	leading	lead	VBG
cord-261532-q923xxn2	303	42	to	to	IN
cord-261532-q923xxn2	303	43	STAT6	stat6	NN
cord-261532-q923xxn2	303	44	activation	activation	NN
cord-261532-q923xxn2	303	45	.	.	.
cord-261532-q923xxn2	304	1	Moreover	moreover	RB
cord-261532-q923xxn2	304	2	,	,	,
cord-261532-q923xxn2	304	3	in	in	IN
cord-261532-q923xxn2	304	4	mast	mast	NN
cord-261532-q923xxn2	304	5	cells	cell	NNS
cord-261532-q923xxn2	304	6	,	,	,
cord-261532-q923xxn2	304	7	kit	kit	NN
cord-261532-q923xxn2	304	8	ligand	ligand	NN
cord-261532-q923xxn2	304	9	(	(	-LRB-
cord-261532-q923xxn2	304	10	KL	KL	NNP
cord-261532-q923xxn2	304	11	)	)	-RRB-
cord-261532-q923xxn2	304	12	,	,	,
cord-261532-q923xxn2	304	13	which	which	WDT
cord-261532-q923xxn2	304	14	is	be	VBZ
cord-261532-q923xxn2	304	15	recognized	recognize	VBN
cord-261532-q923xxn2	304	16	by	by	IN
cord-261532-q923xxn2	304	17	the	the	DT
cord-261532-q923xxn2	304	18	receptor	receptor	NN
cord-261532-q923xxn2	304	19	tyrosine	tyrosine	NN
cord-261532-q923xxn2	304	20	kinase	kinase	NN
cord-261532-q923xxn2	304	21	c	c	NNP
cord-261532-q923xxn2	304	22	-	-	HYPH
cord-261532-q923xxn2	304	23	Kit	kit	NN
cord-261532-q923xxn2	304	24	,	,	,
cord-261532-q923xxn2	304	25	is	be	VBZ
cord-261532-q923xxn2	304	26	implicated	implicate	VBN
cord-261532-q923xxn2	304	27	in	in	IN
cord-261532-q923xxn2	304	28	hematopoiesis	hematopoiesis	NN
cord-261532-q923xxn2	304	29	by	by	IN
cord-261532-q923xxn2	304	30	activating	activate	VBG
cord-261532-q923xxn2	304	31	STAT6	stat6	XX
cord-261532-q923xxn2	305	1	(	(	-LRB-
cord-261532-q923xxn2	305	2	Hundley	Hundley	NNP
cord-261532-q923xxn2	305	3	et	et	NNP
cord-261532-q923xxn2	305	4	al	al	NNP
cord-261532-q923xxn2	305	5	.	.	NNP
cord-261532-q923xxn2	305	6	,	,	,
cord-261532-q923xxn2	305	7	2004	2004	CD
cord-261532-q923xxn2	305	8	)	)	-RRB-
cord-261532-q923xxn2	305	9	.	.	.
cord-261532-q923xxn2	306	1	In	in	IN
cord-261532-q923xxn2	306	2	cardiomyocytes	cardiomyocyte	NNS
cord-261532-q923xxn2	306	3	,	,	,
cord-261532-q923xxn2	306	4	Angiotensin	Angiotensin	NNP
cord-261532-q923xxn2	306	5	II	II	NNP
cord-261532-q923xxn2	306	6	(	(	-LRB-
cord-261532-q923xxn2	306	7	Ang	Ang	NNP
cord-261532-q923xxn2	306	8	II	II	NNP
cord-261532-q923xxn2	306	9	)	)	-RRB-
cord-261532-q923xxn2	306	10	activates	activate	VBZ
cord-261532-q923xxn2	306	11	JAK2	JAK2	NNP
cord-261532-q923xxn2	306	12	and	and	CC
cord-261532-q923xxn2	306	13	STAT6	STAT6	NNS
cord-261532-q923xxn2	306	14	to	to	TO
cord-261532-q923xxn2	306	15	regulate	regulate	VB
cord-261532-q923xxn2	306	16	cardiovascular	cardiovascular	JJ
cord-261532-q923xxn2	306	17	and	and	CC
cord-261532-q923xxn2	306	18	renal	renal	JJ
cord-261532-q923xxn2	306	19	homeostasis	homeostasis	NN
cord-261532-q923xxn2	306	20	.	.	.
cord-261532-q923xxn2	307	1	Moreover	moreover	RB
cord-261532-q923xxn2	307	2	,	,	,
cord-261532-q923xxn2	307	3	one	one	CD
cord-261532-q923xxn2	307	4	leptin	leptin	NN
cord-261532-q923xxn2	307	5	receptor	receptor	NN
cord-261532-q923xxn2	307	6	obese	obese	JJ
cord-261532-q923xxn2	307	7	receptor	receptor	NN
cord-261532-q923xxn2	307	8	(	(	-LRB-
cord-261532-q923xxn2	307	9	OB	OB	NNP
cord-261532-q923xxn2	307	10	-	-	HYPH
cord-261532-q923xxn2	307	11	R	R	NNP
cord-261532-q923xxn2	307	12	)	)	-RRB-
cord-261532-q923xxn2	307	13	splice	splice	NN
cord-261532-q923xxn2	307	14	variant	variant	NN
cord-261532-q923xxn2	307	15	preferentially	preferentially	RB
cord-261532-q923xxn2	307	16	expressed	express	VBN
cord-261532-q923xxn2	307	17	in	in	IN
cord-261532-q923xxn2	307	18	the	the	DT
cord-261532-q923xxn2	307	19	hypothalamus	hypothalamus	NN
cord-261532-q923xxn2	307	20	codes	code	NNS
cord-261532-q923xxn2	307	21	for	for	IN
cord-261532-q923xxn2	307	22	the	the	DT
cord-261532-q923xxn2	307	23	activation	activation	NN
cord-261532-q923xxn2	307	24	of	of	IN
cord-261532-q923xxn2	307	25	STAT6	STAT6	NNS
cord-261532-q923xxn2	307	26	.	.	.
cord-261532-q923xxn2	308	1	Although	although	IN
cord-261532-q923xxn2	308	2	these	these	DT
cord-261532-q923xxn2	308	3	cytokines	cytokine	NNS
cord-261532-q923xxn2	308	4	/	/	SYM
cord-261532-q923xxn2	308	5	factors	factor	NNS
cord-261532-q923xxn2	308	6	showed	show	VBD
cord-261532-q923xxn2	308	7	to	to	TO
cord-261532-q923xxn2	308	8	activate	activate	VB
cord-261532-q923xxn2	308	9	STAT6	STAT6	NNS
cord-261532-q923xxn2	308	10	in	in	IN
cord-261532-q923xxn2	308	11	specific	specific	JJ
cord-261532-q923xxn2	308	12	types	type	NNS
cord-261532-q923xxn2	308	13	of	of	IN
cord-261532-q923xxn2	308	14	cells	cell	NNS
cord-261532-q923xxn2	308	15	,	,	,
cord-261532-q923xxn2	308	16	the	the	DT
cord-261532-q923xxn2	308	17	physiological	physiological	JJ
cord-261532-q923xxn2	308	18	relevance	relevance	NN
cord-261532-q923xxn2	308	19	of	of	IN
cord-261532-q923xxn2	308	20	these	these	DT
cord-261532-q923xxn2	308	21	activation	activation	NN
cord-261532-q923xxn2	308	22	need	need	NN
cord-261532-q923xxn2	308	23	to	to	TO
cord-261532-q923xxn2	308	24	be	be	VB
cord-261532-q923xxn2	308	25	further	further	RB
cord-261532-q923xxn2	308	26	verified	verify	VBN
cord-261532-q923xxn2	308	27	.	.	.
cord-261532-q923xxn2	309	1	Previous	previous	JJ
cord-261532-q923xxn2	309	2	studies	study	NNS
cord-261532-q923xxn2	309	3	suggest	suggest	VBP
cord-261532-q923xxn2	309	4	that	that	IN
cord-261532-q923xxn2	309	5	STAT6	stat6	NN
cord-261532-q923xxn2	309	6	functions	function	NNS
cord-261532-q923xxn2	309	7	only	only	RB
cord-261532-q923xxn2	309	8	in	in	IN
cord-261532-q923xxn2	309	9	adap	adap	JJ
cord-261532-q923xxn2	309	10	-	-	HYPH
cord-261532-q923xxn2	309	11	tive	tive	JJ
cord-261532-q923xxn2	309	12	immune	immune	JJ
cord-261532-q923xxn2	309	13	responses	response	NNS
cord-261532-q923xxn2	309	14	,	,	,
cord-261532-q923xxn2	309	15	but	but	CC
cord-261532-q923xxn2	309	16	our	-PRON-	PRP$
cord-261532-q923xxn2	309	17	recent	recent	JJ
cord-261532-q923xxn2	309	18	publication	publication	NN
cord-261532-q923xxn2	309	19	raised	raise	VBD
cord-261532-q923xxn2	309	20	the	the	DT
cord-261532-q923xxn2	309	21	possibility	possibility	NN
cord-261532-q923xxn2	309	22	that	that	IN
cord-261532-q923xxn2	309	23	STAT6	stat6	NN
cord-261532-q923xxn2	309	24	is	be	VBZ
cord-261532-q923xxn2	309	25	also	also	RB
cord-261532-q923xxn2	309	26	involved	involve	VBN
cord-261532-q923xxn2	309	27	in	in	IN
cord-261532-q923xxn2	309	28	antiviral	antiviral	JJ
cord-261532-q923xxn2	309	29	innate	innate	JJ
cord-261532-q923xxn2	309	30	immunity	immunity	NN
cord-261532-q923xxn2	309	31	.	.	.
cord-261532-q923xxn2	310	1	We	-PRON-	PRP
cord-261532-q923xxn2	310	2	found	find	VBD
cord-261532-q923xxn2	310	3	that	that	IN
cord-261532-q923xxn2	310	4	RNA	RNA	NNP
cord-261532-q923xxn2	310	5	and	and	CC
cord-261532-q923xxn2	310	6	DNA	dna	NN
cord-261532-q923xxn2	310	7	viruses	virus	NNS
cord-261532-q923xxn2	310	8	trigger	trigger	VBP
cord-261532-q923xxn2	310	9	the	the	DT
cord-261532-q923xxn2	310	10	MAVS	MAVS	NNPS
cord-261532-q923xxn2	310	11	/	/	SYM
cord-261532-q923xxn2	310	12	STING	STING	NNP
cord-261532-q923xxn2	310	13	/	/	SYM
cord-261532-q923xxn2	310	14	TBK1	TBK1	NNP
cord-261532-q923xxn2	310	15	axis	axis	NN
cord-261532-q923xxn2	310	16	,	,	,
cord-261532-q923xxn2	310	17	resulting	result	VBG
cord-261532-q923xxn2	310	18	in	in	IN
cord-261532-q923xxn2	310	19	the	the	DT
cord-261532-q923xxn2	310	20	expression	expression	NN
cord-261532-q923xxn2	310	21	of	of	IN
cord-261532-q923xxn2	310	22	both	both	DT
cord-261532-q923xxn2	310	23	type	type	NN
cord-261532-q923xxn2	310	24	I	-PRON-	PRP
cord-261532-q923xxn2	310	25	interferons	interferon	NNS
cord-261532-q923xxn2	310	26	and	and	CC
cord-261532-q923xxn2	310	27	STAT6-regulating	STAT6-regulating	NNP
cord-261532-q923xxn2	310	28	genes	gene	NNS
cord-261532-q923xxn2	310	29	,	,	,
cord-261532-q923xxn2	310	30	including	include	VBG
cord-261532-q923xxn2	310	31	chemokines	chemokine	NNS
cord-261532-q923xxn2	310	32	like	like	IN
cord-261532-q923xxn2	310	33	chemokine	chemokine	NN
cord-261532-q923xxn2	310	34	(	(	-LRB-
cord-261532-q923xxn2	310	35	C	C	NNP
cord-261532-q923xxn2	310	36	-	-	HYPH
cord-261532-q923xxn2	310	37	C	C	NNP
cord-261532-q923xxn2	310	38	motif	motif	NN
cord-261532-q923xxn2	310	39	)	)	-RRB-
cord-261532-q923xxn2	311	1	ligand	ligand	NNP
cord-261532-q923xxn2	311	2	2	2	CD
cord-261532-q923xxn2	312	1	(	(	-LRB-
cord-261532-q923xxn2	312	2	CCL2	CCL2	NNP
cord-261532-q923xxn2	312	3	)	)	-RRB-
cord-261532-q923xxn2	312	4	,	,	,
cord-261532-q923xxn2	312	5	CCL20	ccl20	NN
cord-261532-q923xxn2	312	6	and	and	CC
cord-261532-q923xxn2	312	7	CCL26	CCL26	NNP
cord-261532-q923xxn2	312	8	etc	etc	FW
cord-261532-q923xxn2	312	9	.	.	.
cord-261532-q923xxn2	313	1	Specifically	specifically	RB
cord-261532-q923xxn2	313	2	,	,	,
cord-261532-q923xxn2	313	3	viruses	virus	NNS
cord-261532-q923xxn2	313	4	or	or	CC
cord-261532-q923xxn2	313	5	intracellular	intracellular	JJ
cord-261532-q923xxn2	313	6	nucleic	nucleic	JJ
cord-261532-q923xxn2	313	7	acids	acid	NNS
cord-261532-q923xxn2	313	8	triggers	trigger	VBZ
cord-261532-q923xxn2	313	9	STING	sting	VBP
cord-261532-q923xxn2	313	10	to	to	TO
cord-261532-q923xxn2	313	11	recruit	recruit	VB
cord-261532-q923xxn2	313	12	STAT6	stat6	NN
cord-261532-q923xxn2	313	13	to	to	TO
cord-261532-q923xxn2	313	14	endoplasmic	endoplasmic	VB
cord-261532-q923xxn2	313	15	reticulum	reticulum	NN
cord-261532-q923xxn2	313	16	,	,	,
cord-261532-q923xxn2	313	17	leading	lead	VBG
cord-261532-q923xxn2	313	18	to	to	IN
cord-261532-q923xxn2	313	19	the	the	DT
cord-261532-q923xxn2	313	20	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	313	21	,	,	,
cord-261532-q923xxn2	313	22	dimerization	dimerization	NN
cord-261532-q923xxn2	313	23	and	and	CC
cord-261532-q923xxn2	313	24	nuclear	nuclear	JJ
cord-261532-q923xxn2	313	25	translocation	translocation	NN
cord-261532-q923xxn2	313	26	of	of	IN
cord-261532-q923xxn2	313	27	STAT6	stat6	NN
cord-261532-q923xxn2	313	28	for	for	IN
cord-261532-q923xxn2	313	29	the	the	DT
cord-261532-q923xxn2	313	30	induction	induction	NN
cord-261532-q923xxn2	313	31	of	of	IN
cord-261532-q923xxn2	313	32	specific	specific	JJ
cord-261532-q923xxn2	313	33	target	target	NN
cord-261532-q923xxn2	313	34	genes	gene	NNS
cord-261532-q923xxn2	313	35	responsible	responsible	JJ
cord-261532-q923xxn2	313	36	for	for	IN
cord-261532-q923xxn2	313	37	immune	immune	JJ
cord-261532-q923xxn2	313	38	cell	cell	NN
cord-261532-q923xxn2	313	39	homing	homing	NN
cord-261532-q923xxn2	313	40	.	.	.
cord-261532-q923xxn2	314	1	It	-PRON-	PRP
cord-261532-q923xxn2	314	2	was	be	VBD
cord-261532-q923xxn2	314	3	also	also	RB
cord-261532-q923xxn2	314	4	found	find	VBN
cord-261532-q923xxn2	314	5	that	that	IN
cord-261532-q923xxn2	314	6	activated	activate	VBN
cord-261532-q923xxn2	314	7	STAT6	stat6	NN
cord-261532-q923xxn2	314	8	is	be	VBZ
cord-261532-q923xxn2	314	9	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	314	10	at	at	IN
cord-261532-q923xxn2	314	11	multiple	multiple	JJ
cord-261532-q923xxn2	314	12	sites	site	NNS
cord-261532-q923xxn2	314	13	,	,	,
cord-261532-q923xxn2	314	14	among	among	IN
cord-261532-q923xxn2	314	15	which	which	WDT
cord-261532-q923xxn2	314	16	Ser	Ser	NNP
cord-261532-q923xxn2	314	17	407	407	CD
cord-261532-q923xxn2	314	18	is	be	VBZ
cord-261532-q923xxn2	314	19	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	314	20	by	by	IN
cord-261532-q923xxn2	314	21	TBK1	TBK1	NNP
cord-261532-q923xxn2	314	22	whilst	whilst	IN
cord-261532-q923xxn2	315	1	Tyr	Tyr	NNP
cord-261532-q923xxn2	315	2	641	641	CD
cord-261532-q923xxn2	315	3	is	be	VBZ
cord-261532-q923xxn2	315	4	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	315	5	inde	inde	JJ
cord-261532-q923xxn2	315	6	-	-	HYPH
cord-261532-q923xxn2	315	7	pendent	pendent	NN
cord-261532-q923xxn2	315	8	of	of	IN
cord-261532-q923xxn2	315	9	JAKs	jak	NNS
cord-261532-q923xxn2	315	10	,	,	,
cord-261532-q923xxn2	315	11	possibly	possibly	RB
cord-261532-q923xxn2	315	12	by	by	IN
cord-261532-q923xxn2	315	13	a	a	DT
cord-261532-q923xxn2	315	14	thus	thus	RB
cord-261532-q923xxn2	315	15	unidentified	unidentified	JJ
cord-261532-q923xxn2	315	16	tyrosine	tyrosine	NN
cord-261532-q923xxn2	315	17	kinase	kinase	NN
cord-261532-q923xxn2	315	18	.	.	.
cord-261532-q923xxn2	316	1	Importantly	importantly	RB
cord-261532-q923xxn2	316	2	,	,	,
cord-261532-q923xxn2	316	3	the	the	DT
cord-261532-q923xxn2	316	4	multi	multi	JJ
cord-261532-q923xxn2	316	5	-	-	JJ
cord-261532-q923xxn2	316	6	site	site	JJ
cord-261532-q923xxn2	316	7	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	316	8	of	of	IN
cord-261532-q923xxn2	316	9	STAT6	STAT6	NNS
cord-261532-q923xxn2	316	10	mentioned	mention	VBN
cord-261532-q923xxn2	316	11	above	above	RB
cord-261532-q923xxn2	316	12	is	be	VBZ
cord-261532-q923xxn2	316	13	different	different	JJ
cord-261532-q923xxn2	316	14	from	from	IN
cord-261532-q923xxn2	316	15	the	the	DT
cord-261532-q923xxn2	316	16	classical	classical	JJ
cord-261532-q923xxn2	316	17	IL-4/13	il-4/13	NN
cord-261532-q923xxn2	316	18	pathways	pathway	NNS
cord-261532-q923xxn2	316	19	.	.	.
cord-261532-q923xxn2	317	1	For	for	IN
cord-261532-q923xxn2	317	2	instance	instance	NN
cord-261532-q923xxn2	317	3	,	,	,
cord-261532-q923xxn2	317	4	Leu	Leu	NNP
cord-261532-q923xxn2	317	5	551	551	CD
cord-261532-q923xxn2	317	6	is	be	VBZ
cord-261532-q923xxn2	317	7	essential	essential	JJ
cord-261532-q923xxn2	317	8	for	for	IN
cord-261532-q923xxn2	317	9	STAT6	stat6	NN
cord-261532-q923xxn2	317	10	in	in	IN
cord-261532-q923xxn2	317	11	response	response	NN
cord-261532-q923xxn2	317	12	to	to	IN
cord-261532-q923xxn2	317	13	virus	virus	NN
cord-261532-q923xxn2	317	14	infection	infection	NN
cord-261532-q923xxn2	317	15	,	,	,
cord-261532-q923xxn2	317	16	but	but	CC
cord-261532-q923xxn2	317	17	it	-PRON-	PRP
cord-261532-q923xxn2	317	18	is	be	VBZ
cord-261532-q923xxn2	317	19	not	not	RB
cord-261532-q923xxn2	317	20	phosphorylated	phosphorylate	VBN
cord-261532-q923xxn2	317	21	in	in	IN
cord-261532-q923xxn2	317	22	activated	activate	VBN
cord-261532-q923xxn2	317	23	STAT6	stat6	NN
cord-261532-q923xxn2	317	24	in	in	IN
cord-261532-q923xxn2	317	25	the	the	DT
cord-261532-q923xxn2	317	26	classical	classical	JJ
cord-261532-q923xxn2	317	27	pathways	pathway	NNS
cord-261532-q923xxn2	317	28	.	.	.
cord-261532-q923xxn2	318	1	Stat6	Stat6	NNP
cord-261532-q923xxn2	319	1	-/mice	-/mice	NNP
cord-261532-q923xxn2	319	2	are	be	VBP
cord-261532-q923xxn2	319	3	remarkably	remarkably	RB
cord-261532-q923xxn2	319	4	susceptive	susceptive	JJ
cord-261532-q923xxn2	319	5	to	to	IN
cord-261532-q923xxn2	319	6	virus	virus	NN
cord-261532-q923xxn2	319	7	infection	infection	NN
cord-261532-q923xxn2	319	8	,	,	,
cord-261532-q923xxn2	319	9	and	and	CC
cord-261532-q923xxn2	319	10	all	all	PDT
cord-261532-q923xxn2	319	11	these	these	DT
cord-261532-q923xxn2	319	12	phenomena	phenomenon	NNS
cord-261532-q923xxn2	319	13	revealed	reveal	VBD
cord-261532-q923xxn2	319	14	the	the	DT
cord-261532-q923xxn2	319	15	vital	vital	JJ
cord-261532-q923xxn2	319	16	role	role	NN
cord-261532-q923xxn2	319	17	of	of	IN
cord-261532-q923xxn2	319	18	STAT6	stat6	NN
cord-261532-q923xxn2	319	19	in	in	IN
cord-261532-q923xxn2	319	20	antiviral	antiviral	JJ
cord-261532-q923xxn2	319	21	immune	immune	JJ
cord-261532-q923xxn2	319	22	responses	response	NNS
cord-261532-q923xxn2	319	23	.	.	.
cord-261532-q923xxn2	320	1	Since	since	IN
cord-261532-q923xxn2	320	2	STAT6	stat6	NN
cord-261532-q923xxn2	320	3	is	be	VBZ
cord-261532-q923xxn2	320	4	activated	activate	VBN
cord-261532-q923xxn2	320	5	by	by	IN
cord-261532-q923xxn2	320	6	a	a	DT
cord-261532-q923xxn2	320	7	wide	wide	JJ
cord-261532-q923xxn2	320	8	variety	variety	NN
cord-261532-q923xxn2	320	9	of	of	IN
cord-261532-q923xxn2	320	10	cytokines	cytokine	NNS
cord-261532-q923xxn2	320	11	,	,	,
cord-261532-q923xxn2	320	12	and	and	CC
cord-261532-q923xxn2	320	13	also	also	RB
cord-261532-q923xxn2	320	14	by	by	IN
cord-261532-q923xxn2	320	15	viral	viral	JJ
cord-261532-q923xxn2	320	16	infection	infection	NN
cord-261532-q923xxn2	320	17	,	,	,
cord-261532-q923xxn2	320	18	its	-PRON-	PRP$
cord-261532-q923xxn2	320	19	physiological	physiological	JJ
cord-261532-q923xxn2	320	20	function	function	NN
cord-261532-q923xxn2	320	21	is	be	VBZ
cord-261532-q923xxn2	320	22	highly	highly	RB
cord-261532-q923xxn2	320	23	diversified	diversified	JJ
cord-261532-q923xxn2	320	24	.	.	.
cord-261532-q923xxn2	321	1	Previous	previous	JJ
cord-261532-q923xxn2	321	2	work	work	NN
cord-261532-q923xxn2	321	3	demonstrated	demonstrate	VBD
cord-261532-q923xxn2	321	4	that	that	IN
cord-261532-q923xxn2	321	5	STAT6	stat6	PRP
cord-261532-q923xxn2	321	6	performs	perform	VBZ
cord-261532-q923xxn2	321	7	its	-PRON-	PRP$
cord-261532-q923xxn2	321	8	main	main	JJ
cord-261532-q923xxn2	321	9	role	role	NN
cord-261532-q923xxn2	321	10	in	in	IN
cord-261532-q923xxn2	321	11	mediating	mediate	VBG
cord-261532-q923xxn2	321	12	the	the	DT
cord-261532-q923xxn2	321	13	biologic	biologic	JJ
cord-261532-q923xxn2	321	14	functions	function	NNS
cord-261532-q923xxn2	321	15	of	of	IN
cord-261532-q923xxn2	321	16	IL-4/13	il-4/13	NN
cord-261532-q923xxn2	321	17	,	,	,
cord-261532-q923xxn2	321	18	and	and	CC
cord-261532-q923xxn2	321	19	therefore	therefore	RB
cord-261532-q923xxn2	321	20	connects	connect	VBZ
cord-261532-q923xxn2	321	21	to	to	IN
cord-261532-q923xxn2	321	22	the	the	DT
cord-261532-q923xxn2	321	23	Th2	th2	CD
cord-261532-q923xxn2	321	24	polarization	polarization	NN
cord-261532-q923xxn2	321	25	of	of	IN
cord-261532-q923xxn2	321	26	the	the	DT
cord-261532-q923xxn2	321	27	immune	immune	JJ
cord-261532-q923xxn2	321	28	system	system	NN
cord-261532-q923xxn2	321	29	.	.	.
cord-261532-q923xxn2	322	1	It	-PRON-	PRP
cord-261532-q923xxn2	322	2	has	have	VBZ
cord-261532-q923xxn2	322	3	been	be	VBN
cord-261532-q923xxn2	322	4	shown	show	VBN
cord-261532-q923xxn2	322	5	that	that	IN
cord-261532-q923xxn2	322	6	more	more	JJR
cord-261532-q923xxn2	322	7	than	than	IN
cord-261532-q923xxn2	322	8	150	150	CD
cord-261532-q923xxn2	322	9	genes	gene	NNS
cord-261532-q923xxn2	322	10	were	be	VBD
cord-261532-q923xxn2	322	11	direct	direct	JJ
cord-261532-q923xxn2	322	12	targets	target	NNS
cord-261532-q923xxn2	322	13	of	of	IN
cord-261532-q923xxn2	322	14	activated	activate	VBN
cord-261532-q923xxn2	322	15	STAT6	STAT6	NNS
cord-261532-q923xxn2	322	16	and	and	CC
cord-261532-q923xxn2	322	17	therefore	therefore	RB
cord-261532-q923xxn2	322	18	up	up	RB
cord-261532-q923xxn2	322	19	-	-	HYPH
cord-261532-q923xxn2	322	20	regulated	regulate	VBN
cord-261532-q923xxn2	322	21	by	by	IN
cord-261532-q923xxn2	322	22	IL-4/13	il-4/13	NN
cord-261532-q923xxn2	322	23	treatment	treatment	NN
cord-261532-q923xxn2	322	24	,	,	,
cord-261532-q923xxn2	322	25	most	most	JJS
cord-261532-q923xxn2	322	26	of	of	IN
cord-261532-q923xxn2	322	27	these	these	DT
cord-261532-q923xxn2	322	28	genes	gene	NNS
cord-261532-q923xxn2	322	29	are	be	VBP
cord-261532-q923xxn2	322	30	involved	involve	VBN
cord-261532-q923xxn2	322	31	in	in	IN
cord-261532-q923xxn2	322	32	human	human	JJ
cord-261532-q923xxn2	322	33	Th2	th2	CD
cord-261532-q923xxn2	322	34	cell	cell	NN
cord-261532-q923xxn2	322	35	programming	programming	NN
cord-261532-q923xxn2	322	36	.	.	.
cord-261532-q923xxn2	323	1	STAT6	STAT6	NNP
cord-261532-q923xxn2	323	2	is	be	VBZ
cord-261532-q923xxn2	323	3	also	also	RB
cord-261532-q923xxn2	323	4	shown	show	VBN
cord-261532-q923xxn2	323	5	to	to	TO
cord-261532-q923xxn2	323	6	be	be	VB
cord-261532-q923xxn2	323	7	crucial	crucial	JJ
cord-261532-q923xxn2	323	8	in	in	IN
cord-261532-q923xxn2	323	9	the	the	DT
cord-261532-q923xxn2	323	10	development	development	NN
cord-261532-q923xxn2	323	11	of	of	IN
cord-261532-q923xxn2	323	12	protective	protective	JJ
cord-261532-q923xxn2	323	13	immunity	immunity	NN
cord-261532-q923xxn2	323	14	against	against	IN
cord-261532-q923xxn2	323	15	gastrointestinal	gastrointestinal	JJ
cord-261532-q923xxn2	323	16	nematode	nematode	NN
cord-261532-q923xxn2	323	17	parasites	parasite	NNS
cord-261532-q923xxn2	323	18	.	.	.
cord-261532-q923xxn2	324	1	Infection	infection	NN
cord-261532-q923xxn2	324	2	of	of	IN
cord-261532-q923xxn2	324	3	mice	mouse	NNS
cord-261532-q923xxn2	324	4	with	with	IN
cord-261532-q923xxn2	324	5	intestinal	intestinal	JJ
cord-261532-q923xxn2	324	6	nematode	nematode	NN
cord-261532-q923xxn2	324	7	parasites	parasite	NNS
cord-261532-q923xxn2	324	8	induces	induce	VBZ
cord-261532-q923xxn2	324	9	a	a	DT
cord-261532-q923xxn2	324	10	strong	strong	JJ
cord-261532-q923xxn2	324	11	Th2	th2	CD
cord-261532-q923xxn2	324	12	cytokine	cytokine	NN
cord-261532-q923xxn2	324	13	response	response	NN
cord-261532-q923xxn2	324	14	,	,	,
cord-261532-q923xxn2	324	15	thus	thus	RB
cord-261532-q923xxn2	324	16	triggers	trigger	VBZ
cord-261532-q923xxn2	324	17	worm	worm	NN
cord-261532-q923xxn2	324	18	expulsion	expulsion	NN
cord-261532-q923xxn2	324	19	through	through	IN
cord-261532-q923xxn2	324	20	an	an	DT
cord-261532-q923xxn2	324	21	IL-4Rα	IL-4Rα	NNP
cord-261532-q923xxn2	324	22	-	-	HYPH
cord-261532-q923xxn2	324	23	activated	activate	VBN
cord-261532-q923xxn2	324	24	,	,	,
cord-261532-q923xxn2	324	25	Stat6-dependent	Stat6-dependent	NNP
cord-261532-q923xxn2	324	26	mechanism	mechanism	NN
cord-261532-q923xxn2	324	27	(	(	-LRB-
cord-261532-q923xxn2	324	28	Hoeck	Hoeck	NNP
cord-261532-q923xxn2	324	29	and	and	CC
cord-261532-q923xxn2	324	30	Woisetschläger	Woisetschläger	NNP
cord-261532-q923xxn2	324	31	,	,	,
cord-261532-q923xxn2	324	32	2001	2001	CD
cord-261532-q923xxn2	324	33	)	)	-RRB-
cord-261532-q923xxn2	324	34	.	.	.
cord-261532-q923xxn2	325	1	Besides	besides	IN
cord-261532-q923xxn2	325	2	its	-PRON-	PRP$
cord-261532-q923xxn2	325	3	role	role	NN
cord-261532-q923xxn2	325	4	in	in	IN
cord-261532-q923xxn2	325	5	Th2	Th2	NNP
cord-261532-q923xxn2	325	6	cell	cell	NN
cord-261532-q923xxn2	325	7	development	development	NN
cord-261532-q923xxn2	325	8	and	and	CC
cord-261532-q923xxn2	325	9	immune	immune	JJ
cord-261532-q923xxn2	325	10	response	response	NN
cord-261532-q923xxn2	325	11	against	against	IN
cord-261532-q923xxn2	325	12	nematode	nematode	NN
cord-261532-q923xxn2	325	13	infection	infection	NN
cord-261532-q923xxn2	325	14	,	,	,
cord-261532-q923xxn2	325	15	studies	study	NNS
cord-261532-q923xxn2	325	16	from	from	IN
cord-261532-q923xxn2	325	17	animal	animal	NN
cord-261532-q923xxn2	325	18	models	model	NNS
cord-261532-q923xxn2	325	19	and	and	CC
cord-261532-q923xxn2	325	20	knockout	knockout	NN
cord-261532-q923xxn2	325	21	mice	mouse	NNS
cord-261532-q923xxn2	325	22	demonstrated	demonstrate	VBD
cord-261532-q923xxn2	325	23	that	that	IN
cord-261532-q923xxn2	325	24	STAT6	stat6	NN
cord-261532-q923xxn2	325	25	also	also	RB
cord-261532-q923xxn2	325	26	actively	actively	RB
cord-261532-q923xxn2	325	27	functions	function	VBZ
cord-261532-q923xxn2	325	28	in	in	IN
cord-261532-q923xxn2	325	29	the	the	DT
cord-261532-q923xxn2	325	30	pathogenesis	pathogenesis	NN
cord-261532-q923xxn2	325	31	of	of	IN
cord-261532-q923xxn2	325	32	allergic	allergic	JJ
cord-261532-q923xxn2	325	33	diseases	disease	NNS
cord-261532-q923xxn2	325	34	,	,	,
cord-261532-q923xxn2	325	35	like	like	IN
cord-261532-q923xxn2	325	36	airway	airway	NNP
cord-261532-q923xxn2	325	37	hyperresponsiveness	hyperresponsiveness	NNP
cord-261532-q923xxn2	325	38	(	(	-LRB-
cord-261532-q923xxn2	325	39	AHR	AHR	NNP
cord-261532-q923xxn2	325	40	)	)	-RRB-
cord-261532-q923xxn2	325	41	,	,	,
cord-261532-q923xxn2	325	42	eosinophilic	eosinophilic	JJ
cord-261532-q923xxn2	325	43	inflammation	inflammation	NN
cord-261532-q923xxn2	325	44	,	,	,
cord-261532-q923xxn2	325	45	or	or	CC
cord-261532-q923xxn2	325	46	mucus	mucus	NN
cord-261532-q923xxn2	325	47	production	production	NN
cord-261532-q923xxn2	325	48	.	.	.
cord-261532-q923xxn2	326	1	Asthma	asthma	NN
cord-261532-q923xxn2	326	2	is	be	VBZ
cord-261532-q923xxn2	326	3	a	a	DT
cord-261532-q923xxn2	326	4	chronic	chronic	JJ
cord-261532-q923xxn2	326	5	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	326	6	disorder	disorder	NN
cord-261532-q923xxn2	326	7	on	on	IN
cord-261532-q923xxn2	326	8	remodeled	remodel	VBN
cord-261532-q923xxn2	326	9	airways	airway	NNS
cord-261532-q923xxn2	326	10	,	,	,
cord-261532-q923xxn2	326	11	characterized	characterize	VBN
cord-261532-q923xxn2	326	12	by	by	IN
cord-261532-q923xxn2	326	13	mast	mast	NN
cord-261532-q923xxn2	326	14	cell	cell	NN
cord-261532-q923xxn2	326	15	and	and	CC
cord-261532-q923xxn2	326	16	eosinophil	eosinophil	JJ
cord-261532-q923xxn2	326	17	infiltration	infiltration	NN
cord-261532-q923xxn2	326	18	due	due	IN
cord-261532-q923xxn2	326	19	to	to	IN
cord-261532-q923xxn2	326	20	polarized	polarized	JJ
cord-261532-q923xxn2	326	21	Th2	th2	CD
cord-261532-q923xxn2	326	22	response	response	NN
cord-261532-q923xxn2	326	23	,	,	,
cord-261532-q923xxn2	326	24	leading	lead	VBG
cord-261532-q923xxn2	326	25	to	to	IN
cord-261532-q923xxn2	326	26	the	the	DT
cord-261532-q923xxn2	326	27	abnormal	abnormal	JJ
cord-261532-q923xxn2	326	28	secretion	secretion	NN
cord-261532-q923xxn2	326	29	of	of	IN
cord-261532-q923xxn2	326	30	cytokines	cytokine	NNS
cord-261532-q923xxn2	326	31	like	like	IN
cord-261532-q923xxn2	326	32	IL-3	IL-3	NNP
cord-261532-q923xxn2	326	33	,	,	,
cord-261532-q923xxn2	326	34	-4	-4	NNP
cord-261532-q923xxn2	326	35	,	,	,
cord-261532-q923xxn2	326	36	-5	-5	NNP
cord-261532-q923xxn2	326	37	,	,	,
cord-261532-q923xxn2	326	38	-9	-9	NNP
cord-261532-q923xxn2	326	39	,	,	,
cord-261532-q923xxn2	326	40	-13	-13	CD
cord-261532-q923xxn2	326	41	,	,	,
cord-261532-q923xxn2	326	42	and	and	CC
cord-261532-q923xxn2	326	43	GM	GM	NNP
cord-261532-q923xxn2	326	44	-	-	HYPH
cord-261532-q923xxn2	326	45	CSF	CSF	NNP
cord-261532-q923xxn2	326	46	(	(	-LRB-
cord-261532-q923xxn2	326	47	Sehra	Sehra	NNP
cord-261532-q923xxn2	326	48	et	et	NNP
cord-261532-q923xxn2	326	49	al	al	NNP
cord-261532-q923xxn2	326	50	.	.	NNP
cord-261532-q923xxn2	326	51	,	,	,
cord-261532-q923xxn2	326	52	2010	2010	CD
cord-261532-q923xxn2	326	53	)	)	-RRB-
cord-261532-q923xxn2	326	54	.	.	.
cord-261532-q923xxn2	327	1	It	-PRON-	PRP
cord-261532-q923xxn2	327	2	is	be	VBZ
cord-261532-q923xxn2	327	3	one	one	CD
cord-261532-q923xxn2	327	4	of	of	IN
cord-261532-q923xxn2	327	5	the	the	DT
cord-261532-q923xxn2	327	6	top	top	JJ
cord-261532-q923xxn2	327	7	health	health	NN
cord-261532-q923xxn2	327	8	problems	problem	NNS
cord-261532-q923xxn2	327	9	,	,	,
cord-261532-q923xxn2	327	10	about	about	RB
cord-261532-q923xxn2	327	11	three	three	CD
cord-261532-q923xxn2	327	12	billion	billion	CD
cord-261532-q923xxn2	327	13	people	people	NNS
cord-261532-q923xxn2	327	14	are	be	VBP
cord-261532-q923xxn2	327	15	suffering	suffer	VBG
cord-261532-q923xxn2	327	16	from	from	IN
cord-261532-q923xxn2	327	17	it	-PRON-	PRP
cord-261532-q923xxn2	327	18	worldwide	worldwide	RB
cord-261532-q923xxn2	327	19	.	.	.
cord-261532-q923xxn2	328	1	Recent	recent	JJ
cord-261532-q923xxn2	328	2	studies	study	NNS
cord-261532-q923xxn2	328	3	on	on	IN
cord-261532-q923xxn2	328	4	the	the	DT
cord-261532-q923xxn2	328	5	pathogenic	pathogenic	JJ
cord-261532-q923xxn2	328	6	mechanism	mechanism	NN
cord-261532-q923xxn2	328	7	demonstrate	demonstrate	VBP
cord-261532-q923xxn2	328	8	that	that	IN
cord-261532-q923xxn2	328	9	STAT6-dependent	STAT6-dependent	NNP
cord-261532-q923xxn2	328	10	activation	activation	NN
cord-261532-q923xxn2	328	11	of	of	IN
cord-261532-q923xxn2	328	12	Th2	th2	CD
cord-261532-q923xxn2	328	13	response	response	NN
cord-261532-q923xxn2	328	14	and	and	CC
cord-261532-q923xxn2	328	15	the	the	DT
cord-261532-q923xxn2	328	16	produced	produce	VBN
cord-261532-q923xxn2	328	17	cytokines	cytokine	NNS
cord-261532-q923xxn2	328	18	/	/	SYM
cord-261532-q923xxn2	328	19	chemokines	chemokine	NNS
cord-261532-q923xxn2	328	20	is	be	VBZ
cord-261532-q923xxn2	328	21	essential	essential	JJ
cord-261532-q923xxn2	328	22	for	for	IN
cord-261532-q923xxn2	328	23	the	the	DT
cord-261532-q923xxn2	328	24	initiation	initiation	NN
cord-261532-q923xxn2	328	25	of	of	IN
cord-261532-q923xxn2	328	26	this	this	DT
cord-261532-q923xxn2	328	27	chronic	chronic	JJ
cord-261532-q923xxn2	328	28	inflammation	inflammation	NN
cord-261532-q923xxn2	328	29	.	.	.
cord-261532-q923xxn2	329	1	STAT6	stat6	NN
cord-261532-q923xxn2	329	2	deficiency	deficiency	NN
cord-261532-q923xxn2	329	3	also	also	RB
cord-261532-q923xxn2	329	4	leads	lead	VBZ
cord-261532-q923xxn2	329	5	to	to	IN
cord-261532-q923xxn2	329	6	impaired	impaired	JJ
cord-261532-q923xxn2	329	7	macrophage	macrophage	NN
cord-261532-q923xxn2	329	8	development	development	NN
cord-261532-q923xxn2	329	9	and	and	CC
cord-261532-q923xxn2	329	10	functional	functional	JJ
cord-261532-q923xxn2	329	11	responses	response	NNS
cord-261532-q923xxn2	329	12	,	,	,
cord-261532-q923xxn2	329	13	including	include	VBG
cord-261532-q923xxn2	329	14	morphological	morphological	JJ
cord-261532-q923xxn2	329	15	changes	change	NNS
cord-261532-q923xxn2	329	16	and	and	CC
cord-261532-q923xxn2	329	17	the	the	DT
cord-261532-q923xxn2	329	18	decreased	decrease	VBN
cord-261532-q923xxn2	329	19	MHC	MHC	NNP
cord-261532-q923xxn2	329	20	class	class	NN
cord-261532-q923xxn2	329	21	II	II	NNP
cord-261532-q923xxn2	329	22	expression	expression	NN
cord-261532-q923xxn2	329	23	and	and	CC
cord-261532-q923xxn2	329	24	nitric	nitric	NN
cord-261532-q923xxn2	329	25	oxide	oxide	NN
cord-261532-q923xxn2	329	26	production	production	NN
cord-261532-q923xxn2	329	27	.	.	.
cord-261532-q923xxn2	330	1	In	in	IN
cord-261532-q923xxn2	330	2	addition	addition	NN
cord-261532-q923xxn2	330	3	,	,	,
cord-261532-q923xxn2	330	4	STAT6	STAT6	NNP
cord-261532-q923xxn2	330	5	has	have	VBZ
cord-261532-q923xxn2	330	6	been	be	VBN
cord-261532-q923xxn2	330	7	found	find	VBN
cord-261532-q923xxn2	330	8	to	to	TO
cord-261532-q923xxn2	330	9	be	be	VB
cord-261532-q923xxn2	330	10	constitutively	constitutively	RB
cord-261532-q923xxn2	330	11	activated	activate	VBN
cord-261532-q923xxn2	330	12	in	in	IN
cord-261532-q923xxn2	330	13	transformed	transformed	JJ
cord-261532-q923xxn2	330	14	cell	cell	NN
cord-261532-q923xxn2	330	15	lines	line	NNS
cord-261532-q923xxn2	330	16	,	,	,
cord-261532-q923xxn2	330	17	suggesting	suggest	VBG
cord-261532-q923xxn2	330	18	that	that	IN
cord-261532-q923xxn2	330	19	inappropriate	inappropriate	JJ
cord-261532-q923xxn2	330	20	activation	activation	NN
cord-261532-q923xxn2	330	21	of	of	IN
cord-261532-q923xxn2	330	22	STAT6	stat6	NN
cord-261532-q923xxn2	330	23	is	be	VBZ
cord-261532-q923xxn2	330	24	involved	involve	VBN
cord-261532-q923xxn2	330	25	in	in	IN
cord-261532-q923xxn2	330	26	uncontrolled	uncontrolled	JJ
cord-261532-q923xxn2	330	27	cell	cell	NN
cord-261532-q923xxn2	330	28	growth	growth	NN
cord-261532-q923xxn2	330	29	in	in	IN
cord-261532-q923xxn2	330	30	an	an	DT
cord-261532-q923xxn2	330	31	oncogenic	oncogenic	JJ
cord-261532-q923xxn2	330	32	state	state	NN
cord-261532-q923xxn2	330	33	.	.	.
cord-261532-q923xxn2	331	1	Human	Human	NNP
cord-261532-q923xxn2	331	2	T	T	NNP
cord-261532-q923xxn2	331	3	-	-	HYPH
cord-261532-q923xxn2	331	4	lymphotropic	lymphotropic	NNP
cord-261532-q923xxn2	331	5	virus	virus	NN
cord-261532-q923xxn2	331	6	type	type	NN
cord-261532-q923xxn2	331	7	I	-PRON-	PRP
cord-261532-q923xxn2	331	8	(	(	-LRB-
cord-261532-q923xxn2	331	9	HTLV-1	HTLV-1	NNP
cord-261532-q923xxn2	331	10	)	)	-RRB-
cord-261532-q923xxn2	331	11	transformed	transform	VBN
cord-261532-q923xxn2	331	12	cells	cell	NNS
cord-261532-q923xxn2	331	13	constitutively	constitutively	RB
cord-261532-q923xxn2	331	14	activate	activate	VBP
cord-261532-q923xxn2	331	15	the	the	DT
cord-261532-q923xxn2	331	16	JAK	JAK	NNP
cord-261532-q923xxn2	331	17	-	-	HYPH
cord-261532-q923xxn2	331	18	STAT6	STAT6	NNP
cord-261532-q923xxn2	331	19	pathway	pathway	NN
cord-261532-q923xxn2	331	20	.	.	.
cord-261532-q923xxn2	332	1	However	however	RB
cord-261532-q923xxn2	332	2	,	,	,
cord-261532-q923xxn2	332	3	solid	solid	JJ
cord-261532-q923xxn2	332	4	evidence	evidence	NN
cord-261532-q923xxn2	332	5	for	for	IN
cord-261532-q923xxn2	332	6	the	the	DT
cord-261532-q923xxn2	332	7	involvement	involvement	NN
cord-261532-q923xxn2	332	8	of	of	IN
cord-261532-q923xxn2	332	9	STAT6	stat6	NN
cord-261532-q923xxn2	332	10	in	in	IN
cord-261532-q923xxn2	332	11	cellular	cellular	JJ
cord-261532-q923xxn2	332	12	transformation	transformation	NN
cord-261532-q923xxn2	332	13	is	be	VBZ
cord-261532-q923xxn2	332	14	still	still	RB
cord-261532-q923xxn2	332	15	lacking	lack	VBG
cord-261532-q923xxn2	332	16	.	.	.
cord-261532-q923xxn2	333	1	Recent	recent	JJ
cord-261532-q923xxn2	333	2	work	work	NN
cord-261532-q923xxn2	333	3	found	find	VBD
cord-261532-q923xxn2	333	4	that	that	IN
cord-261532-q923xxn2	333	5	STAT6	stat6	NN
cord-261532-q923xxn2	333	6	plays	play	VBZ
cord-261532-q923xxn2	333	7	an	an	DT
cord-261532-q923xxn2	333	8	important	important	JJ
cord-261532-q923xxn2	333	9	role	role	NN
cord-261532-q923xxn2	333	10	in	in	IN
cord-261532-q923xxn2	333	11	antiviral	antiviral	JJ
cord-261532-q923xxn2	333	12	innate	innate	JJ
cord-261532-q923xxn2	333	13	immunity	immunity	NN
cord-261532-q923xxn2	333	14	.	.	.
cord-261532-q923xxn2	334	1	In	in	IN
cord-261532-q923xxn2	334	2	response	response	NN
cord-261532-q923xxn2	334	3	to	to	IN
cord-261532-q923xxn2	334	4	virus	virus	NN
cord-261532-q923xxn2	334	5	infection	infection	NN
cord-261532-q923xxn2	334	6	,	,	,
cord-261532-q923xxn2	334	7	STAT6	STAT6	NNP
cord-261532-q923xxn2	334	8	was	be	VBD
cord-261532-q923xxn2	334	9	activated	activate	VBN
cord-261532-q923xxn2	334	10	by	by	IN
cord-261532-q923xxn2	334	11	STING	STING	NNP
cord-261532-q923xxn2	334	12	-	-	HYPH
cord-261532-q923xxn2	334	13	TBK1	TBK1	NNP
cord-261532-q923xxn2	334	14	/	/	SYM
cord-261532-q923xxn2	334	15	IKKε	IKKε	NNS
cord-261532-q923xxn2	334	16	.	.	.
cord-261532-q923xxn2	335	1	Activated	activate	VBN
cord-261532-q923xxn2	335	2	STAT6	STAT6	NNS
cord-261532-q923xxn2	335	3	translocated	translocate	VBD
cord-261532-q923xxn2	335	4	to	to	IN
cord-261532-q923xxn2	335	5	nuclei	nucleus	NNS
cord-261532-q923xxn2	335	6	to	to	TO
cord-261532-q923xxn2	335	7	regulate	regulate	VB
cord-261532-q923xxn2	335	8	the	the	DT
cord-261532-q923xxn2	335	9	expression	expression	NN
cord-261532-q923xxn2	335	10	of	of	IN
cord-261532-q923xxn2	335	11	chemokines	chemokine	NNS
cord-261532-q923xxn2	335	12	for	for	IN
cord-261532-q923xxn2	335	13	homing	homing	NN
cord-261532-q923xxn2	335	14	of	of	IN
cord-261532-q923xxn2	335	15	various	various	JJ
cord-261532-q923xxn2	335	16	immune	immune	JJ
cord-261532-q923xxn2	335	17	cells	cell	NNS
cord-261532-q923xxn2	335	18	including	include	VBG
cord-261532-q923xxn2	335	19	lymphocytes	lymphocyte	NNS
cord-261532-q923xxn2	335	20	,	,	,
cord-261532-q923xxn2	335	21	monocytes	monocyte	NNS
cord-261532-q923xxn2	335	22	,	,	,
cord-261532-q923xxn2	335	23	basophils	basophil	NNS
cord-261532-q923xxn2	335	24	,	,	,
cord-261532-q923xxn2	335	25	neutrophils	neutrophil	NNS
cord-261532-q923xxn2	335	26	,	,	,
cord-261532-q923xxn2	335	27	and	and	CC
cord-261532-q923xxn2	335	28	eosinophils	eosinophil	NNS
cord-261532-q923xxn2	335	29	.	.	.
cord-261532-q923xxn2	336	1	The	the	DT
cord-261532-q923xxn2	336	2	physiological	physiological	JJ
cord-261532-q923xxn2	336	3	function	function	NN
cord-261532-q923xxn2	336	4	of	of	IN
cord-261532-q923xxn2	336	5	STAT6	stat6	NN
cord-261532-q923xxn2	336	6	in	in	IN
cord-261532-q923xxn2	336	7	this	this	DT
cord-261532-q923xxn2	336	8	pathway	pathway	NN
cord-261532-q923xxn2	336	9	was	be	VBD
cord-261532-q923xxn2	336	10	highlighted	highlight	VBN
cord-261532-q923xxn2	336	11	as	as	IN
cord-261532-q923xxn2	336	12	Stat6	Stat6	NNP
cord-261532-q923xxn2	337	1	−/−	−/−	NNP
cord-261532-q923xxn2	338	1	mice	mouse	NNS
cord-261532-q923xxn2	338	2	are	be	VBP
cord-261532-q923xxn2	338	3	sensitive	sensitive	JJ
cord-261532-q923xxn2	338	4	to	to	IN
cord-261532-q923xxn2	338	5	both	both	CC
cord-261532-q923xxn2	338	6	DNA	DNA	NNP
cord-261532-q923xxn2	338	7	and	and	CC
cord-261532-q923xxn2	338	8	RNA	RNA	NNP
cord-261532-q923xxn2	338	9	viral	viral	JJ
cord-261532-q923xxn2	338	10	infections	infection	NNS
cord-261532-q923xxn2	338	11	.	.	.
cord-261532-q923xxn2	339	1	Unlike	unlike	IN
cord-261532-q923xxn2	339	2	other	other	JJ
cord-261532-q923xxn2	339	3	STAT6	STAT6	NNS
cord-261532-q923xxn2	339	4	activating	activate	VBG
cord-261532-q923xxn2	339	5	pathways	pathway	NNS
cord-261532-q923xxn2	339	6	that	that	WDT
cord-261532-q923xxn2	339	7	are	be	VBP
cord-261532-q923xxn2	339	8	restricted	restrict	VBN
cord-261532-q923xxn2	339	9	to	to	IN
cord-261532-q923xxn2	339	10	specific	specific	JJ
cord-261532-q923xxn2	339	11	cell	cell	NN
cord-261532-q923xxn2	339	12	types	type	NNS
cord-261532-q923xxn2	339	13	,	,	,
cord-261532-q923xxn2	339	14	virus	virus	NN
cord-261532-q923xxn2	339	15	-	-	HYPH
cord-261532-q923xxn2	339	16	induced	induce	VBN
cord-261532-q923xxn2	339	17	STAT6	stat6	NN
cord-261532-q923xxn2	339	18	activation	activation	NN
cord-261532-q923xxn2	339	19	is	be	VBZ
cord-261532-q923xxn2	339	20	found	find	VBN
cord-261532-q923xxn2	339	21	in	in	IN
cord-261532-q923xxn2	339	22	all	all	DT
cord-261532-q923xxn2	339	23	tested	test	VBN
cord-261532-q923xxn2	339	24	cell	cell	NN
cord-261532-q923xxn2	339	25	types	type	NNS
cord-261532-q923xxn2	339	26	,	,	,
cord-261532-q923xxn2	339	27	suggesting	suggest	VBG
cord-261532-q923xxn2	339	28	the	the	DT
cord-261532-q923xxn2	339	29	fundamental	fundamental	JJ
cord-261532-q923xxn2	339	30	importance	importance	NN
cord-261532-q923xxn2	339	31	of	of	IN
cord-261532-q923xxn2	339	32	this	this	DT
cord-261532-q923xxn2	339	33	signaling	signal	VBG
cord-261532-q923xxn2	339	34	cascade	cascade	NN
cord-261532-q923xxn2	339	35	.	.	.
cord-261532-q923xxn2	340	1	Viral	viral	JJ
cord-261532-q923xxn2	340	2	infection	infection	NN
cord-261532-q923xxn2	340	3	-	-	HYPH
cord-261532-q923xxn2	340	4	activated	activate	VBN
cord-261532-q923xxn2	340	5	STAT6	stat6	NN
cord-261532-q923xxn2	340	6	regulates	regulate	VBZ
cord-261532-q923xxn2	340	7	the	the	DT
cord-261532-q923xxn2	340	8	expression	expression	NN
cord-261532-q923xxn2	340	9	of	of	IN
cord-261532-q923xxn2	340	10	chemotactic	chemotactic	JJ
cord-261532-q923xxn2	340	11	factors	factor	NNS
cord-261532-q923xxn2	340	12	including	include	VBG
cord-261532-q923xxn2	340	13	CCL2	CCL2	NNP
cord-261532-q923xxn2	340	14	,	,	,
cord-261532-q923xxn2	340	15	CCL20	ccl20	NN
cord-261532-q923xxn2	340	16	and	and	CC
cord-261532-q923xxn2	340	17	CCL26	CCL26	NNP
cord-261532-q923xxn2	340	18	.	.	.
cord-261532-q923xxn2	341	1	These	these	DT
cord-261532-q923xxn2	341	2	chemokines	chemokine	NNS
cord-261532-q923xxn2	341	3	have	have	VBP
cord-261532-q923xxn2	341	4	been	be	VBN
cord-261532-q923xxn2	341	5	well	well	RB
cord-261532-q923xxn2	341	6	documented	document	VBN
cord-261532-q923xxn2	341	7	for	for	IN
cord-261532-q923xxn2	341	8	capable	capable	JJ
cord-261532-q923xxn2	341	9	of	of	IN
cord-261532-q923xxn2	341	10	attracting	attract	VBG
cord-261532-q923xxn2	341	11	many	many	JJ
cord-261532-q923xxn2	341	12	types	type	NNS
cord-261532-q923xxn2	341	13	of	of	IN
cord-261532-q923xxn2	341	14	cells	cell	NNS
cord-261532-q923xxn2	341	15	including	include	VBG
cord-261532-q923xxn2	341	16	monocytes	monocyte	NNS
cord-261532-q923xxn2	341	17	,	,	,
cord-261532-q923xxn2	341	18	macrophages	macrophage	NNS
cord-261532-q923xxn2	341	19	,	,	,
cord-261532-q923xxn2	341	20	eosinophils	eosinophil	NNS
cord-261532-q923xxn2	341	21	,	,	,
cord-261532-q923xxn2	341	22	basophils	basophil	NNS
cord-261532-q923xxn2	341	23	,	,	,
cord-261532-q923xxn2	341	24	neutrophils	neutrophil	NNS
cord-261532-q923xxn2	341	25	and	and	CC
cord-261532-q923xxn2	341	26	T	t	NN
cord-261532-q923xxn2	341	27	cells	cell	NNS
cord-261532-q923xxn2	341	28	,	,	,
cord-261532-q923xxn2	341	29	NK	NK	NNP
cord-261532-q923xxn2	341	30	cells	cell	NNS
cord-261532-q923xxn2	341	31	,	,	,
cord-261532-q923xxn2	341	32	and	and	CC
cord-261532-q923xxn2	341	33	therefore	therefore	RB
cord-261532-q923xxn2	341	34	implicated	implicate	VBN
cord-261532-q923xxn2	341	35	in	in	IN
cord-261532-q923xxn2	341	36	the	the	DT
cord-261532-q923xxn2	341	37	pathology	pathology	NN
cord-261532-q923xxn2	341	38	of	of	IN
cord-261532-q923xxn2	341	39	many	many	JJ
cord-261532-q923xxn2	341	40	diseases	disease	NNS
cord-261532-q923xxn2	341	41	characterized	characterize	VBN
cord-261532-q923xxn2	341	42	by	by	IN
cord-261532-q923xxn2	341	43	immune	immune	JJ
cord-261532-q923xxn2	341	44	cell	cell	NN
cord-261532-q923xxn2	341	45	infiltration	infiltration	NN
cord-261532-q923xxn2	341	46	.	.	.
cord-261532-q923xxn2	342	1	CCL2	CCL2	NNP
cord-261532-q923xxn2	342	2	contributes	contribute	VBZ
cord-261532-q923xxn2	342	3	to	to	IN
cord-261532-q923xxn2	342	4	the	the	DT
cord-261532-q923xxn2	342	5	sustained	sustained	JJ
cord-261532-q923xxn2	342	6	inflammation	inflammation	NN
cord-261532-q923xxn2	342	7	in	in	IN
cord-261532-q923xxn2	342	8	chronic	chronic	JJ
cord-261532-q923xxn2	342	9	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	342	10	disorders	disorder	NNS
cord-261532-q923xxn2	342	11	like	like	IN
cord-261532-q923xxn2	342	12	atherosclerosis	atherosclerosis	NN
cord-261532-q923xxn2	342	13	.	.	.
cord-261532-q923xxn2	343	1	It	-PRON-	PRP
cord-261532-q923xxn2	343	2	is	be	VBZ
cord-261532-q923xxn2	343	3	required	require	VBN
cord-261532-q923xxn2	343	4	for	for	IN
cord-261532-q923xxn2	343	5	initiating	initiate	VBG
cord-261532-q923xxn2	343	6	some	some	DT
cord-261532-q923xxn2	343	7	autoimmune	autoimmune	JJ
cord-261532-q923xxn2	343	8	diseases	disease	NNS
cord-261532-q923xxn2	343	9	(	(	-LRB-
cord-261532-q923xxn2	343	10	Mahad	Mahad	NNP
cord-261532-q923xxn2	343	11	and	and	CC
cord-261532-q923xxn2	343	12	Ransohoff	Ransohoff	NNP
cord-261532-q923xxn2	343	13	,	,	,
cord-261532-q923xxn2	343	14	2003	2003	CD
cord-261532-q923xxn2	343	15	)	)	-RRB-
cord-261532-q923xxn2	343	16	,	,	,
cord-261532-q923xxn2	343	17	and	and	CC
cord-261532-q923xxn2	343	18	functions	function	NNS
cord-261532-q923xxn2	343	19	in	in	IN
cord-261532-q923xxn2	343	20	host	host	NN
cord-261532-q923xxn2	343	21	defense	defense	NN
cord-261532-q923xxn2	343	22	against	against	IN
cord-261532-q923xxn2	343	23	various	various	JJ
cord-261532-q923xxn2	343	24	pathogens	pathogen	NNS
cord-261532-q923xxn2	343	25	(	(	-LRB-
cord-261532-q923xxn2	343	26	Winter	Winter	NNP
cord-261532-q923xxn2	343	27	et	et	NNP
cord-261532-q923xxn2	343	28	al	al	NNP
cord-261532-q923xxn2	343	29	.	.	NNP
cord-261532-q923xxn2	343	30	,	,	,
cord-261532-q923xxn2	343	31	2007	2007	CD
cord-261532-q923xxn2	343	32	)	)	-RRB-
cord-261532-q923xxn2	343	33	.	.	.
cord-261532-q923xxn2	344	1	CCL20	CCL20	NNP
cord-261532-q923xxn2	344	2	could	could	MD
cord-261532-q923xxn2	344	3	function	function	VB
cord-261532-q923xxn2	344	4	as	as	IN
cord-261532-q923xxn2	344	5	both	both	CC
cord-261532-q923xxn2	344	6	an	an	DT
cord-261532-q923xxn2	344	7	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	344	8	and	and	CC
cord-261532-q923xxn2	344	9	a	a	DT
cord-261532-q923xxn2	344	10	homeostatic	homeostatic	JJ
cord-261532-q923xxn2	344	11	chemokine	chemokine	NN
cord-261532-q923xxn2	344	12	;	;	:
cord-261532-q923xxn2	344	13	its	-PRON-	PRP$
cord-261532-q923xxn2	344	14	function	function	NN
cord-261532-q923xxn2	344	15	in	in	IN
cord-261532-q923xxn2	344	16	allergic	allergic	JJ
cord-261532-q923xxn2	344	17	airway	airway	NN
cord-261532-q923xxn2	344	18	diseases	disease	NNS
cord-261532-q923xxn2	344	19	has	have	VBZ
cord-261532-q923xxn2	344	20	been	be	VBN
cord-261532-q923xxn2	344	21	well	well	RB
cord-261532-q923xxn2	344	22	documented	document	VBN
cord-261532-q923xxn2	344	23	(	(	-LRB-
cord-261532-q923xxn2	344	24	Weckmann	Weckmann	NNP
cord-261532-q923xxn2	344	25	et	et	NNP
cord-261532-q923xxn2	344	26	al	al	NNP
cord-261532-q923xxn2	344	27	.	.	NNP
cord-261532-q923xxn2	344	28	,	,	,
cord-261532-q923xxn2	344	29	2007	2007	CD
cord-261532-q923xxn2	344	30	)	)	-RRB-
cord-261532-q923xxn2	344	31	.	.	.
cord-261532-q923xxn2	345	1	Recent	recent	JJ
cord-261532-q923xxn2	345	2	work	work	NN
cord-261532-q923xxn2	345	3	also	also	RB
cord-261532-q923xxn2	345	4	suggested	suggest	VBD
cord-261532-q923xxn2	345	5	that	that	IN
cord-261532-q923xxn2	345	6	CCL20	CCL20	NNP
cord-261532-q923xxn2	345	7	was	be	VBD
cord-261532-q923xxn2	345	8	implicated	implicate	VBN
cord-261532-q923xxn2	345	9	in	in	IN
cord-261532-q923xxn2	345	10	the	the	DT
cord-261532-q923xxn2	345	11	pathogenesis	pathogenesis	NN
cord-261532-q923xxn2	345	12	of	of	IN
cord-261532-q923xxn2	345	13	psoriasis	psoriasis	NN
cord-261532-q923xxn2	345	14	.	.	.
cord-261532-q923xxn2	346	1	CCL26	CCL26	NNP
cord-261532-q923xxn2	346	2	has	have	VBZ
cord-261532-q923xxn2	346	3	multiple	multiple	JJ
cord-261532-q923xxn2	346	4	roles	role	NNS
cord-261532-q923xxn2	346	5	in	in	IN
cord-261532-q923xxn2	346	6	allergic	allergic	JJ
cord-261532-q923xxn2	346	7	inflammation	inflammation	NN
cord-261532-q923xxn2	346	8	such	such	JJ
cord-261532-q923xxn2	346	9	as	as	IN
cord-261532-q923xxn2	346	10	atopic	atopic	JJ
cord-261532-q923xxn2	346	11	dermatitis	dermatitis	NN
cord-261532-q923xxn2	346	12	and	and	CC
cord-261532-q923xxn2	346	13	asthma	asthma	NN
cord-261532-q923xxn2	346	14	and	and	CC
cord-261532-q923xxn2	346	15	also	also	RB
cord-261532-q923xxn2	346	16	in	in	IN
cord-261532-q923xxn2	346	17	the	the	DT
cord-261532-q923xxn2	346	18	pathogenesis	pathogenesis	NN
cord-261532-q923xxn2	346	19	of	of	IN
cord-261532-q923xxn2	346	20	eosinophilic	eosinophilic	JJ
cord-261532-q923xxn2	346	21	esophagitis	esophagitis	NN
cord-261532-q923xxn2	346	22	and	and	CC
cord-261532-q923xxn2	346	23	Churg	Churg	NNP
cord-261532-q923xxn2	346	24	-	-	HYPH
cord-261532-q923xxn2	346	25	Strauss	Strauss	NNP
cord-261532-q923xxn2	346	26	syndrome	syndrome	NN
cord-261532-q923xxn2	347	1	(	(	-LRB-
cord-261532-q923xxn2	347	2	Bhattacharya	Bhattacharya	NNP
cord-261532-q923xxn2	347	3	et	et	NNP
cord-261532-q923xxn2	347	4	al	al	NNP
cord-261532-q923xxn2	347	5	.	.	NNP
cord-261532-q923xxn2	347	6	,	,	,
cord-261532-q923xxn2	347	7	2007	2007	CD
cord-261532-q923xxn2	347	8	)	)	-RRB-
cord-261532-q923xxn2	347	9	.	.	.
cord-261532-q923xxn2	348	1	Since	since	IN
cord-261532-q923xxn2	348	2	CX3CR1	CX3CR1	NNP
cord-261532-q923xxn2	348	3	is	be	VBZ
cord-261532-q923xxn2	348	4	involved	involve	VBN
cord-261532-q923xxn2	348	5	in	in	IN
cord-261532-q923xxn2	348	6	Th1-mediated	th1-mediate	VBN
cord-261532-q923xxn2	348	7	diseases	disease	NNS
cord-261532-q923xxn2	348	8	such	such	JJ
cord-261532-q923xxn2	348	9	as	as	IN
cord-261532-q923xxn2	348	10	rheumatoid	rheumatoid	JJ
cord-261532-q923xxn2	348	11	arthritis	arthritis	NN
cord-261532-q923xxn2	348	12	,	,	,
cord-261532-q923xxn2	348	13	diabetes	diabetes	NN
cord-261532-q923xxn2	348	14	,	,	,
cord-261532-q923xxn2	348	15	lichen	lichen	NN
cord-261532-q923xxn2	348	16	planus	planus	NN
cord-261532-q923xxn2	348	17	,	,	,
cord-261532-q923xxn2	348	18	and	and	CC
cord-261532-q923xxn2	348	19	psoriasis	psoriasis	NN
cord-261532-q923xxn2	348	20	,	,	,
cord-261532-q923xxn2	348	21	CCL26	CCL26	NNP
cord-261532-q923xxn2	348	22	is	be	VBZ
cord-261532-q923xxn2	348	23	therefore	therefore	RB
cord-261532-q923xxn2	348	24	likely	likely	RB
cord-261532-q923xxn2	348	25	involved	involve	VBN
cord-261532-q923xxn2	348	26	in	in	IN
cord-261532-q923xxn2	348	27	these	these	DT
cord-261532-q923xxn2	348	28	diseases	disease	NNS
cord-261532-q923xxn2	348	29	as	as	RB
cord-261532-q923xxn2	348	30	well	well	RB
cord-261532-q923xxn2	348	31	(	(	-LRB-
cord-261532-q923xxn2	348	32	Nakayama	Nakayama	NNP
cord-261532-q923xxn2	348	33	et	et	FW
cord-261532-q923xxn2	348	34	al	al	NNP
cord-261532-q923xxn2	348	35	.	.	NNP
cord-261532-q923xxn2	348	36	,	,	,
cord-261532-q923xxn2	348	37	2010	2010	CD
cord-261532-q923xxn2	348	38	)	)	-RRB-
cord-261532-q923xxn2	348	39	.	.	.
cord-261532-q923xxn2	349	1	Given	give	VBN
cord-261532-q923xxn2	349	2	the	the	DT
cord-261532-q923xxn2	349	3	fact	fact	NN
cord-261532-q923xxn2	349	4	that	that	IN
cord-261532-q923xxn2	349	5	viral	viral	JJ
cord-261532-q923xxn2	349	6	-	-	HYPH
cord-261532-q923xxn2	349	7	infection	infection	NN
cord-261532-q923xxn2	349	8	-	-	HYPH
cord-261532-q923xxn2	349	9	activated	activate	VBN
cord-261532-q923xxn2	349	10	STAT6	stat6	NN
cord-261532-q923xxn2	349	11	regulates	regulate	VBZ
cord-261532-q923xxn2	349	12	the	the	DT
cord-261532-q923xxn2	349	13	expression	expression	NN
cord-261532-q923xxn2	349	14	of	of	IN
cord-261532-q923xxn2	349	15	genes	gene	NNS
cord-261532-q923xxn2	349	16	for	for	IN
cord-261532-q923xxn2	349	17	various	various	JJ
cord-261532-q923xxn2	349	18	immune	immune	JJ
cord-261532-q923xxn2	349	19	cells	cell	NNS
cord-261532-q923xxn2	349	20	homing	home	VBG
cord-261532-q923xxn2	349	21	,	,	,
cord-261532-q923xxn2	349	22	the	the	DT
cord-261532-q923xxn2	349	23	physiological	physiological	JJ
cord-261532-q923xxn2	349	24	function	function	NN
cord-261532-q923xxn2	349	25	of	of	IN
cord-261532-q923xxn2	349	26	STAT6	stat6	NN
cord-261532-q923xxn2	349	27	on	on	IN
cord-261532-q923xxn2	349	28	this	this	DT
cord-261532-q923xxn2	349	29	side	side	NN
cord-261532-q923xxn2	349	30	,	,	,
cord-261532-q923xxn2	349	31	especially	especially	RB
cord-261532-q923xxn2	349	32	in	in	IN
cord-261532-q923xxn2	349	33	development	development	NN
cord-261532-q923xxn2	349	34	of	of	IN
cord-261532-q923xxn2	349	35	the	the	DT
cord-261532-q923xxn2	349	36	microbial	microbial	NN
cord-261532-q923xxn2	349	37	-	-	HYPH
cord-261532-q923xxn2	349	38	triggered	trigger	VBN
cord-261532-q923xxn2	349	39	allergic	allergic	JJ
cord-261532-q923xxn2	349	40	diseases	disease	NNS
cord-261532-q923xxn2	349	41	,	,	,
cord-261532-q923xxn2	349	42	is	be	VBZ
cord-261532-q923xxn2	349	43	just	just	RB
cord-261532-q923xxn2	349	44	start	start	NN
cord-261532-q923xxn2	349	45	to	to	TO
cord-261532-q923xxn2	349	46	emerge	emerge	VB
cord-261532-q923xxn2	349	47	.	.	.
cord-261532-q923xxn2	350	1	The	the	DT
cord-261532-q923xxn2	350	2	past	past	JJ
cord-261532-q923xxn2	350	3	two	two	CD
cord-261532-q923xxn2	350	4	decades	decade	NNS
cord-261532-q923xxn2	350	5	have	have	VBP
cord-261532-q923xxn2	350	6	witnessed	witness	VBN
cord-261532-q923xxn2	350	7	great	great	JJ
cord-261532-q923xxn2	350	8	progress	progress	NN
cord-261532-q923xxn2	350	9	in	in	IN
cord-261532-q923xxn2	350	10	the	the	DT
cord-261532-q923xxn2	350	11	understanding	understanding	NN
cord-261532-q923xxn2	350	12	of	of	IN
cord-261532-q923xxn2	350	13	molecular	molecular	JJ
cord-261532-q923xxn2	350	14	mechanisms	mechanism	NNS
cord-261532-q923xxn2	350	15	underlying	underlie	VBG
cord-261532-q923xxn2	350	16	innate	innate	JJ
cord-261532-q923xxn2	350	17	immune	immune	JJ
cord-261532-q923xxn2	350	18	activation	activation	NN
cord-261532-q923xxn2	350	19	,	,	,
cord-261532-q923xxn2	350	20	providing	provide	VBG
cord-261532-q923xxn2	350	21	important	important	JJ
cord-261532-q923xxn2	350	22	clues	clue	NNS
cord-261532-q923xxn2	350	23	to	to	IN
cord-261532-q923xxn2	350	24	how	how	WRB
cord-261532-q923xxn2	350	25	host	host	NN
cord-261532-q923xxn2	350	26	cells	cell	NNS
cord-261532-q923xxn2	350	27	recognize	recognize	VBP
cord-261532-q923xxn2	350	28	and	and	CC
cord-261532-q923xxn2	350	29	resist	resist	VB
cord-261532-q923xxn2	350	30	the	the	DT
cord-261532-q923xxn2	350	31	microbial	microbial	JJ
cord-261532-q923xxn2	350	32	harassment	harassment	NN
cord-261532-q923xxn2	350	33	.	.	.
cord-261532-q923xxn2	351	1	Various	various	JJ
cord-261532-q923xxn2	351	2	pathogenic	pathogenic	JJ
cord-261532-q923xxn2	351	3	microorganisms	microorganism	NNS
cord-261532-q923xxn2	351	4	invading	invade	VBG
cord-261532-q923xxn2	351	5	the	the	DT
cord-261532-q923xxn2	351	6	host	host	NN
cord-261532-q923xxn2	351	7	can	can	MD
cord-261532-q923xxn2	351	8	be	be	VB
cord-261532-q923xxn2	351	9	identified	identify	VBN
cord-261532-q923xxn2	351	10	by	by	IN
cord-261532-q923xxn2	351	11	different	different	JJ
cord-261532-q923xxn2	351	12	PRRs	prr	NNS
cord-261532-q923xxn2	351	13	,	,	,
cord-261532-q923xxn2	351	14	and	and	CC
cord-261532-q923xxn2	351	15	through	through	IN
cord-261532-q923xxn2	351	16	the	the	DT
cord-261532-q923xxn2	351	17	innate	innate	JJ
cord-261532-q923xxn2	351	18	immune	immune	NN
cord-261532-q923xxn2	351	19	signaling	signal	VBG
cord-261532-q923xxn2	351	20	network	network	NN
cord-261532-q923xxn2	351	21	,	,	,
cord-261532-q923xxn2	351	22	these	these	DT
cord-261532-q923xxn2	351	23	diverse	diverse	JJ
cord-261532-q923xxn2	351	24	signals	signal	NNS
cord-261532-q923xxn2	351	25	go	go	VBP
cord-261532-q923xxn2	351	26	to	to	IN
cord-261532-q923xxn2	351	27	the	the	DT
cord-261532-q923xxn2	351	28	corresponding	correspond	VBG
cord-261532-q923xxn2	351	29	hub	hub	NN
cord-261532-q923xxn2	351	30	molecules	molecule	NNS
cord-261532-q923xxn2	351	31	including	include	VBG
cord-261532-q923xxn2	351	32	MyD88	MyD88	NNS
cord-261532-q923xxn2	351	33	,	,	,
cord-261532-q923xxn2	351	34	TRIF	TRIF	NNP
cord-261532-q923xxn2	351	35	,	,	,
cord-261532-q923xxn2	351	36	MAVS	MAVS	NNP
cord-261532-q923xxn2	351	37	,	,	,
cord-261532-q923xxn2	351	38	STING	STING	NNP
cord-261532-q923xxn2	351	39	and	and	CC
cord-261532-q923xxn2	351	40	Caspase-1	Caspase-1	NNP
cord-261532-q923xxn2	351	41	,	,	,
cord-261532-q923xxn2	351	42	which	which	WDT
cord-261532-q923xxn2	351	43	drive	drive	VBP
cord-261532-q923xxn2	351	44	the	the	DT
cord-261532-q923xxn2	351	45	relevant	relevant	JJ
cord-261532-q923xxn2	351	46	downstream	downstream	JJ
cord-261532-q923xxn2	351	47	transcriptional	transcriptional	JJ
cord-261532-q923xxn2	351	48	factors	factor	NNS
cord-261532-q923xxn2	352	1	IRF3/7	IRF3/7	NNP
cord-261532-q923xxn2	352	2	,	,	,
cord-261532-q923xxn2	352	3	NF	NF	NNP
cord-261532-q923xxn2	352	4	-	-	HYPH
cord-261532-q923xxn2	352	5	κB	κB	NNP
cord-261532-q923xxn2	352	6	,	,	,
cord-261532-q923xxn2	353	1	AP-1	AP-1	NNP
cord-261532-q923xxn2	353	2	and/or	and/or	CC
cord-261532-q923xxn2	353	3	STAT6	stat6	XX
cord-261532-q923xxn2	354	1	to	to	TO
cord-261532-q923xxn2	354	2	induce	induce	VB
cord-261532-q923xxn2	354	3	the	the	DT
cord-261532-q923xxn2	354	4	expression	expression	NN
cord-261532-q923xxn2	354	5	of	of	IN
cord-261532-q923xxn2	354	6	innate	innate	JJ
cord-261532-q923xxn2	354	7	immune	immune	NN
cord-261532-q923xxn2	354	8	-	-	HYPH
cord-261532-q923xxn2	354	9	related	relate	VBN
cord-261532-q923xxn2	354	10	genes	gene	NNS
cord-261532-q923xxn2	354	11	,	,	,
cord-261532-q923xxn2	354	12	leading	lead	VBG
cord-261532-q923xxn2	354	13	to	to	IN
cord-261532-q923xxn2	354	14	the	the	DT
cord-261532-q923xxn2	354	15	elimination	elimination	NN
cord-261532-q923xxn2	354	16	of	of	IN
cord-261532-q923xxn2	354	17	the	the	DT
cord-261532-q923xxn2	354	18	microbe	microbe	NN
cord-261532-q923xxn2	354	19	and	and	CC
cord-261532-q923xxn2	354	20	the	the	DT
cord-261532-q923xxn2	354	21	activation	activation	NN
cord-261532-q923xxn2	354	22	of	of	IN
cord-261532-q923xxn2	354	23	the	the	DT
cord-261532-q923xxn2	354	24	adaptive	adaptive	JJ
cord-261532-q923xxn2	354	25	immunity	immunity	NN
cord-261532-q923xxn2	354	26	.	.	.
cord-261532-q923xxn2	355	1	Since	since	IN
cord-261532-q923xxn2	355	2	PPRs	ppr	NNS
cord-261532-q923xxn2	355	3	,	,	,
cord-261532-q923xxn2	355	4	their	-PRON-	PRP$
cord-261532-q923xxn2	355	5	relevant	relevant	JJ
cord-261532-q923xxn2	355	6	signaling	signal	VBG
cord-261532-q923xxn2	355	7	adapters	adapter	NNS
cord-261532-q923xxn2	355	8	and	and	CC
cord-261532-q923xxn2	355	9	downstream	downstream	JJ
cord-261532-q923xxn2	355	10	molecules	molecule	NNS
cord-261532-q923xxn2	355	11	locate	locate	VBP
cord-261532-q923xxn2	355	12	in	in	IN
cord-261532-q923xxn2	355	13	different	different	JJ
cord-261532-q923xxn2	355	14	cellular	cellular	JJ
cord-261532-q923xxn2	355	15	position	position	NN
cord-261532-q923xxn2	355	16	,	,	,
cord-261532-q923xxn2	355	17	so	so	CC
cord-261532-q923xxn2	355	18	it	-PRON-	PRP
cord-261532-q923xxn2	355	19	is	be	VBZ
cord-261532-q923xxn2	355	20	of	of	IN
cord-261532-q923xxn2	355	21	fundamental	fundamental	JJ
cord-261532-q923xxn2	355	22	importance	importance	NN
cord-261532-q923xxn2	355	23	to	to	TO
cord-261532-q923xxn2	355	24	elaborate	elaborate	VB
cord-261532-q923xxn2	355	25	how	how	WRB
cord-261532-q923xxn2	355	26	different	different	JJ
cord-261532-q923xxn2	355	27	signaling	signal	VBG
cord-261532-q923xxn2	355	28	pathways	pathway	NNS
cord-261532-q923xxn2	355	29	were	be	VBD
cord-261532-q923xxn2	355	30	utilized	utilize	VBN
cord-261532-q923xxn2	355	31	in	in	IN
cord-261532-q923xxn2	355	32	different	different	JJ
cord-261532-q923xxn2	355	33	cellular	cellular	JJ
cord-261532-q923xxn2	355	34	contexts	context	NNS
cord-261532-q923xxn2	355	35	.	.	.
cord-261532-q923xxn2	356	1	It	-PRON-	PRP
cord-261532-q923xxn2	356	2	is	be	VBZ
cord-261532-q923xxn2	356	3	found	find	VBN
cord-261532-q923xxn2	356	4	that	that	IN
cord-261532-q923xxn2	356	5	almost	almost	RB
cord-261532-q923xxn2	356	6	of	of	IN
cord-261532-q923xxn2	356	7	the	the	DT
cord-261532-q923xxn2	356	8	signaling	signal	VBG
cord-261532-q923xxn2	356	9	molecules	molecule	NNS
cord-261532-q923xxn2	356	10	studied	study	VBD
cord-261532-q923xxn2	356	11	distributed	distribute	VBN
cord-261532-q923xxn2	356	12	differently	differently	RB
cord-261532-q923xxn2	356	13	,	,	,
cord-261532-q923xxn2	356	14	exemplified	exemplify	VBD
cord-261532-q923xxn2	356	15	that	that	IN
cord-261532-q923xxn2	356	16	the	the	DT
cord-261532-q923xxn2	356	17	mRNA	mRNA	NNP
cord-261532-q923xxn2	356	18	expression	expression	NN
cord-261532-q923xxn2	356	19	of	of	IN
cord-261532-q923xxn2	356	20	10	10	CD
cord-261532-q923xxn2	356	21	TLRs	tlr	NNS
cord-261532-q923xxn2	356	22	and	and	CC
cord-261532-q923xxn2	356	23	21	21	CD
cord-261532-q923xxn2	356	24	related	related	JJ
cord-261532-q923xxn2	356	25	genes	gene	NNS
cord-261532-q923xxn2	356	26	performed	perform	VBD
cord-261532-q923xxn2	356	27	quite	quite	RB
cord-261532-q923xxn2	356	28	variously	variously	RB
cord-261532-q923xxn2	356	29	in	in	IN
cord-261532-q923xxn2	356	30	different	different	JJ
cord-261532-q923xxn2	356	31	tissues	tissue	NNS
cord-261532-q923xxn2	356	32	and	and	CC
cord-261532-q923xxn2	356	33	cell	cell	NN
cord-261532-q923xxn2	356	34	lines	line	NNS
cord-261532-q923xxn2	356	35	(	(	-LRB-
cord-261532-q923xxn2	356	36	Masuhiro	Masuhiro	NNP
cord-261532-q923xxn2	356	37	and	and	CC
cord-261532-q923xxn2	356	38	Shinsaku	Shinsaku	NNP
cord-261532-q923xxn2	356	39	,	,	,
cord-261532-q923xxn2	356	40	2005	2005	CD
cord-261532-q923xxn2	356	41	)	)	-RRB-
cord-261532-q923xxn2	356	42	.	.	.
cord-261532-q923xxn2	357	1	Besides	besides	RB
cord-261532-q923xxn2	357	2	,	,	,
cord-261532-q923xxn2	357	3	the	the	DT
cord-261532-q923xxn2	357	4	influence	influence	NN
cord-261532-q923xxn2	357	5	of	of	IN
cord-261532-q923xxn2	357	6	MyD88	MyD88	NNS
cord-261532-q923xxn2	357	7	on	on	IN
cord-261532-q923xxn2	357	8	the	the	DT
cord-261532-q923xxn2	357	9	gene	gene	NN
cord-261532-q923xxn2	357	10	expression	expression	NN
cord-261532-q923xxn2	357	11	during	during	IN
cord-261532-q923xxn2	357	12	sepsis	sepsis	NN
cord-261532-q923xxn2	357	13	is	be	VBZ
cord-261532-q923xxn2	357	14	strikingly	strikingly	RB
cord-261532-q923xxn2	357	15	organ	organ	NN
cord-261532-q923xxn2	357	16	-	-	HYPH
cord-261532-q923xxn2	357	17	specific	specific	JJ
cord-261532-q923xxn2	358	1	(	(	-LRB-
cord-261532-q923xxn2	358	2	Heike	Heike	NNP
cord-261532-q923xxn2	358	3	et	et	NNP
cord-261532-q923xxn2	358	4	al	al	NNP
cord-261532-q923xxn2	358	5	.	.	NNP
cord-261532-q923xxn2	358	6	,	,	,
cord-261532-q923xxn2	358	7	2006	2006	CD
cord-261532-q923xxn2	358	8	)	)	-RRB-
cord-261532-q923xxn2	358	9	.	.	.
cord-261532-q923xxn2	359	1	The	the	DT
cord-261532-q923xxn2	359	2	ability	ability	NN
cord-261532-q923xxn2	359	3	of	of	IN
cord-261532-q923xxn2	359	4	PRRs	prr	NNS
cord-261532-q923xxn2	359	5	to	to	TO
cord-261532-q923xxn2	359	6	engage	engage	VB
cord-261532-q923xxn2	359	7	different	different	JJ
cord-261532-q923xxn2	359	8	adaptor	adaptor	NN
cord-261532-q923xxn2	359	9	proteins	protein	NNS
cord-261532-q923xxn2	359	10	,	,	,
cord-261532-q923xxn2	359	11	crosstalk	crosstalk	NN
cord-261532-q923xxn2	359	12	with	with	IN
cord-261532-q923xxn2	359	13	other	other	JJ
cord-261532-q923xxn2	359	14	regulatory	regulatory	JJ
cord-261532-q923xxn2	359	15	pathways	pathway	NNS
cord-261532-q923xxn2	359	16	and	and	CC
cord-261532-q923xxn2	359	17	suppress	suppress	VB
cord-261532-q923xxn2	359	18	or	or	CC
cord-261532-q923xxn2	359	19	activate	activate	VB
cord-261532-q923xxn2	359	20	a	a	DT
cord-261532-q923xxn2	359	21	plethora	plethora	NN
cord-261532-q923xxn2	359	22	of	of	IN
cord-261532-q923xxn2	359	23	kinases	kinase	NNS
cord-261532-q923xxn2	359	24	involved	involve	VBN
cord-261532-q923xxn2	359	25	in	in	IN
cord-261532-q923xxn2	359	26	a	a	DT
cord-261532-q923xxn2	359	27	multitude	multitude	NN
cord-261532-q923xxn2	359	28	of	of	IN
cord-261532-q923xxn2	359	29	signaling	signal	VBG
cord-261532-q923xxn2	359	30	pathways	pathway	NNS
cord-261532-q923xxn2	359	31	is	be	VBZ
cord-261532-q923xxn2	359	32	an	an	DT
cord-261532-q923xxn2	359	33	essential	essential	JJ
cord-261532-q923xxn2	359	34	factor	factor	NN
cord-261532-q923xxn2	359	35	in	in	IN
cord-261532-q923xxn2	359	36	shaping	shape	VBG
cord-261532-q923xxn2	359	37	the	the	DT
cord-261532-q923xxn2	359	38	type	type	NN
cord-261532-q923xxn2	359	39	,	,	,
cord-261532-q923xxn2	359	40	strength	strength	NN
cord-261532-q923xxn2	359	41	,	,	,
cord-261532-q923xxn2	359	42	magnitude	magnitude	NN
cord-261532-q923xxn2	359	43	,	,	,
cord-261532-q923xxn2	359	44	timing	timing	NN
cord-261532-q923xxn2	359	45	and	and	CC
cord-261532-q923xxn2	359	46	duration	duration	NN
cord-261532-q923xxn2	359	47	of	of	IN
cord-261532-q923xxn2	359	48	inflammation	inflammation	NN
cord-261532-q923xxn2	359	49	and	and	CC
cord-261532-q923xxn2	359	50	antiviral	antiviral	JJ
cord-261532-q923xxn2	359	51	responses	response	NNS
cord-261532-q923xxn2	359	52	.	.	.
cord-261532-q923xxn2	360	1	This	this	DT
cord-261532-q923xxn2	360	2	multidimensional	multidimensional	JJ
cord-261532-q923xxn2	360	3	signaling	signal	VBG
cord-261532-q923xxn2	360	4	network	network	NN
cord-261532-q923xxn2	360	5	precisely	precisely	RB
cord-261532-q923xxn2	360	6	regulates	regulate	VBZ
cord-261532-q923xxn2	360	7	both	both	CC
cord-261532-q923xxn2	360	8	the	the	DT
cord-261532-q923xxn2	360	9	innate	innate	JJ
cord-261532-q923xxn2	360	10	and	and	CC
cord-261532-q923xxn2	360	11	adaptive	adaptive	JJ
cord-261532-q923xxn2	360	12	immune	immune	JJ
cord-261532-q923xxn2	360	13	systems	system	NNS
cord-261532-q923xxn2	360	14	.	.	.
cord-261532-q923xxn2	361	1	Nevertheless	nevertheless	RB
cord-261532-q923xxn2	361	2	,	,	,
cord-261532-q923xxn2	361	3	our	-PRON-	PRP$
cord-261532-q923xxn2	361	4	knowledge	knowledge	NN
cord-261532-q923xxn2	361	5	of	of	IN
cord-261532-q923xxn2	361	6	inflammation	inflammation	NN
cord-261532-q923xxn2	361	7	and	and	CC
cord-261532-q923xxn2	361	8	antiviral	antiviral	JJ
cord-261532-q923xxn2	361	9	biology	biology	NN
cord-261532-q923xxn2	361	10	is	be	VBZ
cord-261532-q923xxn2	361	11	still	still	RB
cord-261532-q923xxn2	361	12	in	in	IN
cord-261532-q923xxn2	361	13	its	-PRON-	PRP$
cord-261532-q923xxn2	361	14	infancy	infancy	NN
cord-261532-q923xxn2	361	15	and	and	CC
cord-261532-q923xxn2	361	16	many	many	JJ
cord-261532-q923xxn2	361	17	problems	problem	NNS
cord-261532-q923xxn2	361	18	remain	remain	VBP
cord-261532-q923xxn2	361	19	obscure	obscure	JJ
cord-261532-q923xxn2	361	20	.	.	.
cord-261532-q923xxn2	362	1	Specifically	specifically	RB
cord-261532-q923xxn2	362	2	,	,	,
cord-261532-q923xxn2	362	3	the	the	DT
cord-261532-q923xxn2	362	4	substantial	substantial	JJ
cord-261532-q923xxn2	362	5	antimicrobial	antimicrobial	JJ
cord-261532-q923xxn2	362	6	mechanisms	mechanism	NNS
cord-261532-q923xxn2	362	7	actually	actually	RB
cord-261532-q923xxn2	362	8	are	be	VBP
cord-261532-q923xxn2	362	9	beyond	beyond	IN
cord-261532-q923xxn2	362	10	our	-PRON-	PRP$
cord-261532-q923xxn2	362	11	understanding	understanding	NN
cord-261532-q923xxn2	362	12	.	.	.
cord-261532-q923xxn2	363	1	Furthermore	furthermore	RB
cord-261532-q923xxn2	363	2	,	,	,
cord-261532-q923xxn2	363	3	we	-PRON-	PRP
cord-261532-q923xxn2	363	4	do	do	VBP
cord-261532-q923xxn2	363	5	not	not	RB
cord-261532-q923xxn2	363	6	know	know	VB
cord-261532-q923xxn2	363	7	much	much	JJ
cord-261532-q923xxn2	363	8	about	about	IN
cord-261532-q923xxn2	363	9	the	the	DT
cord-261532-q923xxn2	363	10	dynamic	dynamic	JJ
cord-261532-q923xxn2	363	11	regulation	regulation	NN
cord-261532-q923xxn2	363	12	of	of	IN
cord-261532-q923xxn2	363	13	the	the	DT
cord-261532-q923xxn2	363	14	entire	entire	JJ
cord-261532-q923xxn2	363	15	immune	immune	JJ
cord-261532-q923xxn2	363	16	system	system	NN
cord-261532-q923xxn2	363	17	caused	cause	VBN
cord-261532-q923xxn2	363	18	by	by	IN
cord-261532-q923xxn2	363	19	crosstalk	crosstalk	NN
cord-261532-q923xxn2	363	20	of	of	IN
cord-261532-q923xxn2	363	21	multiple	multiple	JJ
cord-261532-q923xxn2	363	22	signaling	signaling	NN
cord-261532-q923xxn2	363	23	cascades	cascade	NNS
cord-261532-q923xxn2	363	24	as	as	RB
cord-261532-q923xxn2	363	25	well	well	RB
cord-261532-q923xxn2	363	26	as	as	IN
cord-261532-q923xxn2	363	27	the	the	DT
cord-261532-q923xxn2	363	28	mechanisms	mechanism	NNS
cord-261532-q923xxn2	363	29	fine	fine	RB
cord-261532-q923xxn2	363	30	-	-	HYPH
cord-261532-q923xxn2	363	31	tuning	tuning	VB
cord-261532-q923xxn2	363	32	the	the	DT
cord-261532-q923xxn2	363	33	innate	innate	JJ
cord-261532-q923xxn2	363	34	and	and	CC
cord-261532-q923xxn2	363	35	adaptive	adaptive	JJ
cord-261532-q923xxn2	363	36	immunity	immunity	NN
cord-261532-q923xxn2	363	37	.	.	.
cord-261532-q923xxn2	364	1	Future	future	JJ
cord-261532-q923xxn2	364	2	investigations	investigation	NNS
cord-261532-q923xxn2	364	3	urgently	urgently	RB
cord-261532-q923xxn2	364	4	need	need	VBP
cord-261532-q923xxn2	364	5	the	the	DT
cord-261532-q923xxn2	364	6	introduction	introduction	NN
cord-261532-q923xxn2	364	7	of	of	IN
cord-261532-q923xxn2	364	8	more	more	RBR
cord-261532-q923xxn2	364	9	advanced	advanced	JJ
cord-261532-q923xxn2	364	10	and	and	CC
cord-261532-q923xxn2	364	11	effective	effective	JJ
cord-261532-q923xxn2	364	12	approaches	approach	NNS
cord-261532-q923xxn2	364	13	,	,	,
cord-261532-q923xxn2	364	14	such	such	JJ
cord-261532-q923xxn2	364	15	as	as	IN
cord-261532-q923xxn2	364	16	imaging	imaging	NN
cord-261532-q923xxn2	364	17	techniques	technique	NNS
cord-261532-q923xxn2	364	18	that	that	WDT
cord-261532-q923xxn2	364	19	can	can	MD
cord-261532-q923xxn2	364	20	be	be	VB
cord-261532-q923xxn2	364	21	used	use	VBN
cord-261532-q923xxn2	364	22	to	to	TO
cord-261532-q923xxn2	364	23	define	define	VB
cord-261532-q923xxn2	364	24	the	the	DT
cord-261532-q923xxn2	364	25	dynamics	dynamic	NNS
cord-261532-q923xxn2	364	26	of	of	IN
cord-261532-q923xxn2	364	27	immune	immune	JJ
cord-261532-q923xxn2	364	28	cell	cell	NN
cord-261532-q923xxn2	364	29	behavior	behavior	NN
cord-261532-q923xxn2	364	30	and	and	CC
cord-261532-q923xxn2	364	31	the	the	DT
cord-261532-q923xxn2	364	32	system	system	NN
cord-261532-q923xxn2	364	33	biology	biology	NN
cord-261532-q923xxn2	364	34	strategy	strategy	NN
cord-261532-q923xxn2	364	35	to	to	TO
cord-261532-q923xxn2	364	36	analyze	analyze	VB
cord-261532-q923xxn2	364	37	and	and	CC
cord-261532-q923xxn2	364	38	integrate	integrate	VB
cord-261532-q923xxn2	364	39	accumulating	accumulate	VBG
cord-261532-q923xxn2	364	40	knowledge	knowledge	NN
cord-261532-q923xxn2	365	1	(	(	-LRB-
cord-261532-q923xxn2	365	2	Chevrier	Chevrier	NNP
cord-261532-q923xxn2	365	3	et	et	NNP
cord-261532-q923xxn2	365	4	al	al	NNP
cord-261532-q923xxn2	365	5	.	.	.
cord-261532-q923xxn2	366	1	,	,	,
cord-261532-q923xxn2	366	2	2011	2011	CD
cord-261532-q923xxn2	366	3	)	)	-RRB-
cord-261532-q923xxn2	366	4	.	.	.
cord-261532-q923xxn2	367	1	In	in	IN
cord-261532-q923xxn2	367	2	future	future	NN
cord-261532-q923xxn2	367	3	,	,	,
cord-261532-q923xxn2	367	4	these	these	DT
cord-261532-q923xxn2	367	5	sophisticated	sophisticated	JJ
cord-261532-q923xxn2	367	6	methods	method	NNS
cord-261532-q923xxn2	367	7	will	will	MD
cord-261532-q923xxn2	367	8	definitely	definitely	RB
cord-261532-q923xxn2	367	9	enable	enable	VB
cord-261532-q923xxn2	367	10	scientists	scientist	NNS
cord-261532-q923xxn2	367	11	to	to	TO
cord-261532-q923xxn2	367	12	indentify	indentify	VB
cord-261532-q923xxn2	367	13	unknown	unknown	JJ
cord-261532-q923xxn2	367	14	PRRs	prr	NNS
cord-261532-q923xxn2	367	15	exemplified	exemplify	VBD
cord-261532-q923xxn2	367	16	the	the	DT
cord-261532-q923xxn2	367	17	unidentified	unidentified	JJ
cord-261532-q923xxn2	367	18	DNA	dna	NN
cord-261532-q923xxn2	367	19	sensors	sensor	NNS
cord-261532-q923xxn2	367	20	and	and	CC
cord-261532-q923xxn2	367	21	uncover	uncover	VB
cord-261532-q923xxn2	367	22	the	the	DT
cord-261532-q923xxn2	367	23	initiation	initiation	NN
cord-261532-q923xxn2	367	24	innate	innate	JJ
cord-261532-q923xxn2	367	25	immunity	immunity	NN
cord-261532-q923xxn2	367	26	and	and	CC
cord-261532-q923xxn2	367	27	the	the	DT
cord-261532-q923xxn2	367	28	integration	integration	NN
cord-261532-q923xxn2	367	29	of	of	IN
cord-261532-q923xxn2	367	30	the	the	DT
cord-261532-q923xxn2	367	31	signaling	signal	VBG
cord-261532-q923xxn2	367	32	cascades	cascade	NNS
cord-261532-q923xxn2	367	33	.	.	.
cord-261532-q923xxn2	368	1	How	how	WRB
cord-261532-q923xxn2	368	2	to	to	TO
cord-261532-q923xxn2	368	3	apply	apply	VB
cord-261532-q923xxn2	368	4	to	to	TO
cord-261532-q923xxn2	368	5	use	use	VB
cord-261532-q923xxn2	368	6	theoretical	theoretical	JJ
cord-261532-q923xxn2	368	7	knowledge	knowledge	NN
cord-261532-q923xxn2	368	8	to	to	IN
cord-261532-q923xxn2	368	9	clinic	clinic	NN
cord-261532-q923xxn2	368	10	drug	drug	NN
cord-261532-q923xxn2	368	11	design	design	NN
cord-261532-q923xxn2	368	12	and	and	CC
cord-261532-q923xxn2	368	13	therapy	therapy	NN
cord-261532-q923xxn2	368	14	for	for	IN
cord-261532-q923xxn2	368	15	autoimmune	autoimmune	JJ
cord-261532-q923xxn2	368	16	diseases	disease	NNS
cord-261532-q923xxn2	368	17	will	will	MD
cord-261532-q923xxn2	368	18	be	be	VB
cord-261532-q923xxn2	368	19	a	a	DT
cord-261532-q923xxn2	368	20	huge	huge	JJ
cord-261532-q923xxn2	368	21	challenge	challenge	NN
cord-261532-q923xxn2	368	22	.	.	.
cord-261532-q923xxn2	369	1	ABBREVIATIONS	abbreviation	NNS
cord-261532-q923xxn2	369	2	γC	γC	NNP
cord-261532-q923xxn2	369	3	,	,	,
cord-261532-q923xxn2	369	4	gamma	gamma	NN
cord-261532-q923xxn2	369	5	chain	chain	NN
cord-261532-q923xxn2	369	6	;	;	:
cord-261532-q923xxn2	369	7	AHR	AHR	NNP
cord-261532-q923xxn2	369	8	,	,	,
cord-261532-q923xxn2	369	9	airway	airway	NNP
cord-261532-q923xxn2	369	10	hyperresponsiveness	hyperresponsiveness	NNP
cord-261532-q923xxn2	369	11	;	;	:
cord-261532-q923xxn2	369	12	Ang	Ang	NNP
cord-261532-q923xxn2	369	13	II	II	NNP
cord-261532-q923xxn2	369	14	,	,	,
cord-261532-q923xxn2	369	15	Angiotensin	Angiotensin	NNP
cord-261532-q923xxn2	369	16	II	II	NNP
cord-261532-q923xxn2	369	17	;	;	:
cord-261532-q923xxn2	370	1	AP-1	AP-1	NNP
cord-261532-q923xxn2	370	2	,	,	,
cord-261532-q923xxn2	370	3	activator	activator	NN
cord-261532-q923xxn2	370	4	protein	protein	NN
cord-261532-q923xxn2	370	5	1	1	CD
cord-261532-q923xxn2	370	6	;	;	:
cord-261532-q923xxn2	370	7	ATG	ATG	NNP
cord-261532-q923xxn2	370	8	,	,	,
cord-261532-q923xxn2	370	9	autophagy	autophagy	NN
cord-261532-q923xxn2	370	10	-	-	HYPH
cord-261532-q923xxn2	370	11	related	relate	VBN
cord-261532-q923xxn2	370	12	gene	gene	NN
cord-261532-q923xxn2	370	13	;	;	:
cord-261532-q923xxn2	370	14	CARD	card	NN
cord-261532-q923xxn2	370	15	,	,	,
cord-261532-q923xxn2	370	16	Caspase	Caspase	NNP
cord-261532-q923xxn2	370	17	recruitment	recruitment	NN
cord-261532-q923xxn2	370	18	domain	domain	NN
cord-261532-q923xxn2	370	19	;	;	:
cord-261532-q923xxn2	370	20	Cardif	Cardif	NNP
cord-261532-q923xxn2	370	21	,	,	,
cord-261532-q923xxn2	370	22	CARD	card	NN
cord-261532-q923xxn2	370	23	adaptor	adaptor	NN
cord-261532-q923xxn2	370	24	inducing	induce	VBG
cord-261532-q923xxn2	370	25	IFN	IFN	NNP
cord-261532-q923xxn2	370	26	-	-	HYPH
cord-261532-q923xxn2	370	27	β	β	NNP
cord-261532-q923xxn2	370	28	;	;	:
cord-261532-q923xxn2	370	29	cDC	cDC	NNP
cord-261532-q923xxn2	370	30	,	,	,
cord-261532-q923xxn2	370	31	conventional	conventional	JJ
cord-261532-q923xxn2	370	32	DC	DC	NNP
cord-261532-q923xxn2	370	33	;	;	:
cord-261532-q923xxn2	370	34	DBD	DBD	NNP
cord-261532-q923xxn2	370	35	,	,	,
cord-261532-q923xxn2	370	36	DNA	dna	NN
cord-261532-q923xxn2	370	37	binding	binding	NN
cord-261532-q923xxn2	370	38	domain	domain	NN
cord-261532-q923xxn2	370	39	;	;	:
cord-261532-q923xxn2	370	40	DC	DC	NNP
cord-261532-q923xxn2	370	41	,	,	,
cord-261532-q923xxn2	370	42	dendritic	dendritic	JJ
cord-261532-q923xxn2	370	43	cell	cell	NN
cord-261532-q923xxn2	370	44	;	;	:
cord-261532-q923xxn2	370	45	DUBA	DUBA	NNP
cord-261532-q923xxn2	370	46	,	,	,
cord-261532-q923xxn2	370	47	deubiquitinating	deubiquitinating	NN
cord-261532-q923xxn2	370	48	enzyme	enzyme	NN
cord-261532-q923xxn2	370	49	A	a	NN
cord-261532-q923xxn2	370	50	;	;	:
cord-261532-q923xxn2	370	51	EMSV	EMSV	NNP
cord-261532-q923xxn2	370	52	,	,	,
cord-261532-q923xxn2	370	53	encephalomyocarditis	encephalomyocarditis	NN
cord-261532-q923xxn2	370	54	virus	virus	NN
cord-261532-q923xxn2	370	55	;	;	:
cord-261532-q923xxn2	370	56	ER	ER	NNP
cord-261532-q923xxn2	370	57	,	,	,
cord-261532-q923xxn2	370	58	endoplasmic	endoplasmic	NN
cord-261532-q923xxn2	370	59	reticulum	reticulum	NN
cord-261532-q923xxn2	370	60	;	;	:
cord-261532-q923xxn2	370	61	ERIS	ERIS	NNP
cord-261532-q923xxn2	370	62	,	,	,
cord-261532-q923xxn2	370	63	ER	ER	NNP
cord-261532-q923xxn2	370	64	interferon	interferon	NN
cord-261532-q923xxn2	370	65	stimulator	stimulator	NN
cord-261532-q923xxn2	370	66	;	;	:
cord-261532-q923xxn2	370	67	EYA4	EYA4	NNP
cord-261532-q923xxn2	370	68	,	,	,
cord-261532-q923xxn2	370	69	eyes	eye	NNS
cord-261532-q923xxn2	370	70	absent	absent	JJ
cord-261532-q923xxn2	370	71	4	4	CD
cord-261532-q923xxn2	370	72	;	;	:
cord-261532-q923xxn2	370	73	FADD	FADD	NNP
cord-261532-q923xxn2	370	74	,	,	,
cord-261532-q923xxn2	370	75	Fas	Fas	NNP
cord-261532-q923xxn2	370	76	-	-	HYPH
cord-261532-q923xxn2	370	77	associated	associate	VBN
cord-261532-q923xxn2	370	78	death	death	NN
cord-261532-q923xxn2	370	79	domain	domain	NN
cord-261532-q923xxn2	370	80	protein	protein	NN
cord-261532-q923xxn2	370	81	IFN	IFN	NNP
cord-261532-q923xxn2	370	82	,	,	,
cord-261532-q923xxn2	370	83	interferon	interferon	NN
cord-261532-q923xxn2	370	84	;	;	:
cord-261532-q923xxn2	370	85	HcoV	HcoV	NNP
cord-261532-q923xxn2	370	86	,	,	,
cord-261532-q923xxn2	370	87	human	human	JJ
cord-261532-q923xxn2	370	88	coronavirus	coronavirus	NN
cord-261532-q923xxn2	370	89	;	;	:
cord-261532-q923xxn2	370	90	HCV	HCV	NNP
cord-261532-q923xxn2	370	91	,	,	,
cord-261532-q923xxn2	370	92	hepatitis	hepatitis	NN
cord-261532-q923xxn2	370	93	C	c	NN
cord-261532-q923xxn2	370	94	virus	virus	NN
cord-261532-q923xxn2	370	95	;	;	:
cord-261532-q923xxn2	370	96	HTLV-1	HTLV-1	NNP
cord-261532-q923xxn2	370	97	.	.	.
cord-261532-q923xxn2	371	1	T	T	NNP
cord-261532-q923xxn2	371	2	-	-	HYPH
cord-261532-q923xxn2	371	3	lymphotropic	lymphotropic	NNP
cord-261532-q923xxn2	371	4	virus	virus	NN
cord-261532-q923xxn2	371	5	type	type	NN
cord-261532-q923xxn2	371	6	I	-PRON-	PRP
cord-261532-q923xxn2	371	7	;	;	:
cord-261532-q923xxn2	371	8	HIV	HIV	NNP
cord-261532-q923xxn2	371	9	,	,	,
cord-261532-q923xxn2	371	10	human	human	JJ
cord-261532-q923xxn2	371	11	immunodeficiency	immunodeficiency	NN
cord-261532-q923xxn2	371	12	virus	virus	NN
cord-261532-q923xxn2	371	13	;	;	:
cord-261532-q923xxn2	371	14	HMGB1	HMGB1	NNP
cord-261532-q923xxn2	371	15	,	,	,
cord-261532-q923xxn2	371	16	high	high	JJ
cord-261532-q923xxn2	371	17	-	-	HYPH
cord-261532-q923xxn2	371	18	mobility	mobility	NN
cord-261532-q923xxn2	371	19	group	group	NN
cord-261532-q923xxn2	371	20	protein	protein	NN
cord-261532-q923xxn2	371	21	B1	b1	NN
cord-261532-q923xxn2	371	22	;	;	:
cord-261532-q923xxn2	371	23	HSV	HSV	NNP
cord-261532-q923xxn2	371	24	,	,	,
cord-261532-q923xxn2	371	25	herpes	herpes	NN
cord-261532-q923xxn2	371	26	simplex	simplex	NN
cord-261532-q923xxn2	371	27	virus	virus	NN
cord-261532-q923xxn2	371	28	type	type	NN
cord-261532-q923xxn2	371	29	;	;	:
cord-261532-q923xxn2	371	30	IFIX	IFIX	NNP
cord-261532-q923xxn2	371	31	,	,	,
cord-261532-q923xxn2	371	32	IFN	IFN	NNP
cord-261532-q923xxn2	371	33	-	-	HYPH
cord-261532-q923xxn2	371	34	inducible	inducible	JJ
cord-261532-q923xxn2	371	35	protein	protein	NN
cord-261532-q923xxn2	371	36	X	x	NN
cord-261532-q923xxn2	371	37	;	;	:
cord-261532-q923xxn2	371	38	Ig	ig	UH
cord-261532-q923xxn2	371	39	,	,	,
cord-261532-q923xxn2	371	40	immunoglobulin	immunoglobulin	NN
cord-261532-q923xxn2	371	41	;	;	:
cord-261532-q923xxn2	371	42	IRAK	IRAK	NNP
cord-261532-q923xxn2	371	43	,	,	,
cord-261532-q923xxn2	372	1	IL-1R	il-1r	CD
cord-261532-q923xxn2	372	2	-	-	HYPH
cord-261532-q923xxn2	372	3	associated	associate	VBN
cord-261532-q923xxn2	372	4	kinase	kinase	NN
cord-261532-q923xxn2	372	5	;	;	:
cord-261532-q923xxn2	372	6	IRF	IRF	NNP
cord-261532-q923xxn2	372	7	,	,	,
cord-261532-q923xxn2	372	8	interferon	interferon	NN
cord-261532-q923xxn2	372	9	regulatory	regulatory	JJ
cord-261532-q923xxn2	372	10	factors	factor	NNS
cord-261532-q923xxn2	372	11	;	;	:
cord-261532-q923xxn2	372	12	IPS-1	IPS-1	NNP
cord-261532-q923xxn2	372	13	,	,	,
cord-261532-q923xxn2	372	14	interferon	interferon	NN
cord-261532-q923xxn2	372	15	promoter	promoter	NN
cord-261532-q923xxn2	372	16	stimulator-1	stimulator-1	NNP
cord-261532-q923xxn2	372	17	;	;	:
cord-261532-q923xxn2	372	18	ISG	ISG	NNP
cord-261532-q923xxn2	372	19	,	,	,
cord-261532-q923xxn2	372	20	IFN	IFN	NNP
cord-261532-q923xxn2	372	21	-	-	HYPH
cord-261532-q923xxn2	372	22	stimulated	stimulate	VBN
cord-261532-q923xxn2	372	23	gene	gene	NN
cord-261532-q923xxn2	372	24	;	;	:
cord-261532-q923xxn2	372	25	JEV	JEV	NNP
cord-261532-q923xxn2	372	26	,	,	,
cord-261532-q923xxn2	372	27	Japanese	Japanese	NNP
cord-261532-q923xxn2	372	28	Encephalitis	Encephalitis	NNP
cord-261532-q923xxn2	372	29	virus	virus	NN
cord-261532-q923xxn2	372	30	;	;	:
cord-261532-q923xxn2	372	31	KL	KL	NNP
cord-261532-q923xxn2	372	32	,	,	,
cord-261532-q923xxn2	372	33	kit	kit	NN
cord-261532-q923xxn2	372	34	ligand	ligand	NN
cord-261532-q923xxn2	372	35	;	;	:
cord-261532-q923xxn2	372	36	LD	LD	NNP
cord-261532-q923xxn2	372	37	,	,	,
cord-261532-q923xxn2	372	38	linker	linker	NN
cord-261532-q923xxn2	372	39	domain	domain	NN
cord-261532-q923xxn2	372	40	;	;	:
cord-261532-q923xxn2	372	41	LF	lf	NN
cord-261532-q923xxn2	372	42	,	,	,
cord-261532-q923xxn2	372	43	lethal	lethal	JJ
cord-261532-q923xxn2	372	44	factor	factor	NN
cord-261532-q923xxn2	372	45	;	;	:
cord-261532-q923xxn2	372	46	LGP2	LGP2	NNP
cord-261532-q923xxn2	372	47	,	,	,
cord-261532-q923xxn2	372	48	laboratory	laboratory	NN
cord-261532-q923xxn2	372	49	of	of	IN
cord-261532-q923xxn2	372	50	genetics	genetic	NNS
cord-261532-q923xxn2	372	51	and	and	CC
cord-261532-q923xxn2	372	52	physiology	physiology	NN
cord-261532-q923xxn2	372	53	2	2	CD
cord-261532-q923xxn2	372	54	;	;	:
cord-261532-q923xxn2	372	55	LRR	LRR	NNP
cord-261532-q923xxn2	372	56	,	,	,
cord-261532-q923xxn2	372	57	leucine	leucine	NN
cord-261532-q923xxn2	372	58	-	-	HYPH
cord-261532-q923xxn2	372	59	rich	rich	JJ
cord-261532-q923xxn2	372	60	repeats	repeat	NNS
cord-261532-q923xxn2	372	61	;	;	:
cord-261532-q923xxn2	373	1	MAP2K6	MAP2K6	NNS
cord-261532-q923xxn2	373	2	(	(	-LRB-
cord-261532-q923xxn2	373	3	MKK6	MKK6	NNP
cord-261532-q923xxn2	373	4	)	)	-RRB-
cord-261532-q923xxn2	373	5	,	,	,
cord-261532-q923xxn2	373	6	mitogen	mitogen	NN
cord-261532-q923xxn2	373	7	-	-	HYPH
cord-261532-q923xxn2	373	8	activated	activate	VBN
cord-261532-q923xxn2	373	9	protein	protein	NN
cord-261532-q923xxn2	373	10	kinase	kinase	NN
cord-261532-q923xxn2	373	11	kinase	kinase	VBZ
cord-261532-q923xxn2	373	12	6	6	CD
cord-261532-q923xxn2	373	13	;	;	.
cord-261532-q923xxn2	374	1	MAVS	MAVS	NNP
cord-261532-q923xxn2	374	2	,	,	,
cord-261532-q923xxn2	374	3	mitochondrial	mitochondrial	NN
cord-261532-q923xxn2	375	1	antiviral	antiviral	JJ
cord-261532-q923xxn2	375	2	signaling	signal	VBG
cord-261532-q923xxn2	375	3	protein	protein	NN
cord-261532-q923xxn2	375	4	;	;	:
cord-261532-q923xxn2	375	5	MDP	MDP	NNP
cord-261532-q923xxn2	375	6	,	,	,
cord-261532-q923xxn2	375	7	muramyl	muramyl	NNP
cord-261532-q923xxn2	375	8	dipeptide	dipeptide	NNP
cord-261532-q923xxn2	375	9	;	;	:
cord-261532-q923xxn2	375	10	MEF	MEF	NNP
cord-261532-q923xxn2	375	11	,	,	,
cord-261532-q923xxn2	375	12	mouse	mouse	NN
cord-261532-q923xxn2	375	13	embryonic	embryonic	JJ
cord-261532-q923xxn2	375	14	fibroblast	fibroblast	NN
cord-261532-q923xxn2	375	15	;	;	:
cord-261532-q923xxn2	375	16	MNDA	MNDA	NNP
cord-261532-q923xxn2	375	17	,	,	,
cord-261532-q923xxn2	375	18	myeloid	myeloid	JJ
cord-261532-q923xxn2	375	19	nuclear	nuclear	JJ
cord-261532-q923xxn2	375	20	differentiation	differentiation	NN
cord-261532-q923xxn2	375	21	antigen	antigen	NN
cord-261532-q923xxn2	375	22	;	;	:
cord-261532-q923xxn2	375	23	MyD88	MyD88	NNS
cord-261532-q923xxn2	375	24	,	,	,
cord-261532-q923xxn2	375	25	myeloid	myeloid	JJ
cord-261532-q923xxn2	375	26	differentiation	differentiation	NN
cord-261532-q923xxn2	375	27	primary	primary	JJ
cord-261532-q923xxn2	375	28	response	response	NN
cord-261532-q923xxn2	375	29	gene	gene	NN
cord-261532-q923xxn2	375	30	88	88	CD
cord-261532-q923xxn2	375	31	;	;	:
cord-261532-q923xxn2	375	32	NDV	NDV	NNP
cord-261532-q923xxn2	375	33	,	,	,
cord-261532-q923xxn2	375	34	Newcastle	Newcastle	NNP
cord-261532-q923xxn2	375	35	disease	disease	NN
cord-261532-q923xxn2	375	36	virus	virus	NN
cord-261532-q923xxn2	375	37	;	;	:
cord-261532-q923xxn2	375	38	NEMO	NEMO	NNP
cord-261532-q923xxn2	375	39	,	,	,
cord-261532-q923xxn2	375	40	NF	NF	NNP
cord-261532-q923xxn2	375	41	-	-	HYPH
cord-261532-q923xxn2	375	42	κB	κb	CD
cord-261532-q923xxn2	375	43	essential	essential	JJ
cord-261532-q923xxn2	375	44	modulator	modulator	NN
cord-261532-q923xxn2	375	45	;	;	:
cord-261532-q923xxn2	375	46	NF	nf	NN
cord-261532-q923xxn2	375	47	-	-	HYPH
cord-261532-q923xxn2	375	48	κB	κB	NNP
cord-261532-q923xxn2	375	49	,	,	,
cord-261532-q923xxn2	375	50	nuclear	nuclear	JJ
cord-261532-q923xxn2	375	51	factor	factor	NN
cord-261532-q923xxn2	375	52	κB	κb	CD
cord-261532-q923xxn2	375	53	;	;	:
cord-261532-q923xxn2	376	1	NLRP1	NLRP1	NNP
cord-261532-q923xxn2	376	2	,	,	,
cord-261532-q923xxn2	376	3	NLR	NLR	NNP
cord-261532-q923xxn2	376	4	family	family	NN
cord-261532-q923xxn2	376	5	PYD	PYD	NNP
cord-261532-q923xxn2	376	6	-	-	HYPH
cord-261532-q923xxn2	376	7	containing	contain	VBG
cord-261532-q923xxn2	376	8	1	1	CD
cord-261532-q923xxn2	376	9	;	;	:
cord-261532-q923xxn2	377	1	NLRC4	NLRC4	NNP
cord-261532-q923xxn2	377	2	,	,	,
cord-261532-q923xxn2	377	3	NLR	NLR	NNP
cord-261532-q923xxn2	377	4	family	family	NN
cord-261532-q923xxn2	377	5	CARD	card	NN
cord-261532-q923xxn2	377	6	-	-	:
cord-261532-q923xxn2	377	7	containing	contain	VBG
cord-261532-q923xxn2	377	8	4	4	CD
cord-261532-q923xxn2	377	9	;	;	:
cord-261532-q923xxn2	377	10	NOD	nod	XX
cord-261532-q923xxn2	377	11	,	,	,
cord-261532-q923xxn2	377	12	nucleotide	nucleotide	NN
cord-261532-q923xxn2	377	13	-	-	HYPH
cord-261532-q923xxn2	377	14	binding	bind	VBG
cord-261532-q923xxn2	377	15	and	and	CC
cord-261532-q923xxn2	377	16	oligomerization	oligomerization	NN
cord-261532-q923xxn2	377	17	;	;	:
cord-261532-q923xxn2	377	18	OB	OB	NNP
cord-261532-q923xxn2	377	19	-	-	HYPH
cord-261532-q923xxn2	377	20	R	R	NNP
cord-261532-q923xxn2	377	21	,	,	,
cord-261532-q923xxn2	377	22	obese	obese	JJ
cord-261532-q923xxn2	377	23	receptor	receptor	NN
cord-261532-q923xxn2	377	24	;	;	.
cord-261532-q923xxn2	378	1	pDC	pDC	NNP
cord-261532-q923xxn2	378	2	,	,	,
cord-261532-q923xxn2	378	3	plasmacytoid	plasmacytoid	NNP
cord-261532-q923xxn2	378	4	DC	DC	NNP
cord-261532-q923xxn2	378	5	;	;	:
cord-261532-q923xxn2	378	6	pDGF	pdgf	JJ
cord-261532-q923xxn2	378	7	,	,	,
cord-261532-q923xxn2	378	8	platelet	platelet	NN
cord-261532-q923xxn2	378	9	-	-	HYPH
cord-261532-q923xxn2	378	10	derived	derive	VBN
cord-261532-q923xxn2	378	11	growth	growth	NN
cord-261532-q923xxn2	378	12	factor	factor	NN
cord-261532-q923xxn2	378	13	;	;	:
cord-261532-q923xxn2	378	14	PLP	PLP	NNP
cord-261532-q923xxn2	378	15	,	,	,
cord-261532-q923xxn2	378	16	papain	papain	NN
cord-261532-q923xxn2	378	17	-	-	HYPH
cord-261532-q923xxn2	378	18	like	like	JJ
cord-261532-q923xxn2	378	19	protease	protease	NN
cord-261532-q923xxn2	378	20	;	;	:
cord-261532-q923xxn2	378	21	PRR	PRR	NNP
cord-261532-q923xxn2	378	22	,	,	,
cord-261532-q923xxn2	378	23	pattern	pattern	NN
cord-261532-q923xxn2	378	24	recognition	recognition	NN
cord-261532-q923xxn2	378	25	receptor	receptor	NN
cord-261532-q923xxn2	378	26	;	;	:
cord-261532-q923xxn2	378	27	PYD	PYD	NNP
cord-261532-q923xxn2	378	28	,	,	,
cord-261532-q923xxn2	378	29	pyrin	pyrin	NN
cord-261532-q923xxn2	378	30	domain	domain	NN
cord-261532-q923xxn2	378	31	;	;	:
cord-261532-q923xxn2	378	32	RIP	RIP	NNP
cord-261532-q923xxn2	378	33	,	,	,
cord-261532-q923xxn2	378	34	RHIM	rhim	NN
cord-261532-q923xxn2	378	35	-	-	HYPH
cord-261532-q923xxn2	378	36	receptor	receptor	NN
cord-261532-q923xxn2	378	37	-	-	HYPH
cord-261532-q923xxn2	378	38	interacting	interact	VBG
cord-261532-q923xxn2	378	39	protein	protein	NN
cord-261532-q923xxn2	378	40	;	;	:
cord-261532-q923xxn2	378	41	ROS	ROS	NNP
cord-261532-q923xxn2	378	42	,	,	,
cord-261532-q923xxn2	378	43	reactive	reactive	JJ
cord-261532-q923xxn2	378	44	oxygen	oxygen	NN
cord-261532-q923xxn2	378	45	species	specie	NNS
cord-261532-q923xxn2	378	46	;	;	:
cord-261532-q923xxn2	378	47	SARS	SARS	NNP
cord-261532-q923xxn2	378	48	,	,	,
cord-261532-q923xxn2	378	49	severe	severe	JJ
cord-261532-q923xxn2	378	50	acute	acute	JJ
cord-261532-q923xxn2	378	51	respiratory	respiratory	JJ
cord-261532-q923xxn2	378	52	syndrome	syndrome	NN
cord-261532-q923xxn2	378	53	;	;	:
cord-261532-q923xxn2	378	54	SeV	SeV	NNP
cord-261532-q923xxn2	378	55	,	,	,
cord-261532-q923xxn2	378	56	Sendai	Sendai	NNP
cord-261532-q923xxn2	378	57	virus	virus	NN
cord-261532-q923xxn2	378	58	;	;	:
cord-261532-q923xxn2	378	59	STAT	stat	NN
cord-261532-q923xxn2	378	60	,	,	,
cord-261532-q923xxn2	378	61	signal	signal	NN
cord-261532-q923xxn2	378	62	transducer	transducer	NN
cord-261532-q923xxn2	378	63	and	and	CC
cord-261532-q923xxn2	378	64	activator	activator	NN
cord-261532-q923xxn2	378	65	of	of	IN
cord-261532-q923xxn2	378	66	transcription	transcription	NN
cord-261532-q923xxn2	378	67	;	;	:
cord-261532-q923xxn2	378	68	SH2	SH2	NNP
cord-261532-q923xxn2	378	69	,	,	,
cord-261532-q923xxn2	378	70	Src	Src	NNP
cord-261532-q923xxn2	378	71	homology	homology	NN
cord-261532-q923xxn2	378	72	2	2	CD
cord-261532-q923xxn2	378	73	;	;	:
cord-261532-q923xxn2	378	74	SOCS	SOCS	NNP
cord-261532-q923xxn2	378	75	,	,	,
cord-261532-q923xxn2	378	76	suppressor	suppressor	NN
cord-261532-q923xxn2	378	77	of	of	IN
cord-261532-q923xxn2	378	78	cytokine	cytokine	NN
cord-261532-q923xxn2	378	79	signaling	signaling	NN
cord-261532-q923xxn2	378	80	;	;	:
cord-261532-q923xxn2	378	81	STING	sting	NN
cord-261532-q923xxn2	378	82	,	,	,
cord-261532-q923xxn2	378	83	stimulator	stimulator	NN
cord-261532-q923xxn2	378	84	of	of	IN
cord-261532-q923xxn2	378	85	interferon	interferon	NN
cord-261532-q923xxn2	378	86	genes	gene	NNS
cord-261532-q923xxn2	378	87	;	;	:
cord-261532-q923xxn2	378	88	T3SS	T3SS	NNP
cord-261532-q923xxn2	378	89	,	,	,
cord-261532-q923xxn2	378	90	Type	type	NN
cord-261532-q923xxn2	378	91	III	III	NNP
cord-261532-q923xxn2	378	92	secretion	secretion	NN
cord-261532-q923xxn2	378	93	system	system	NN
cord-261532-q923xxn2	378	94	;	;	:
cord-261532-q923xxn2	378	95	TAD	TAD	NNP
cord-261532-q923xxn2	378	96	,	,	,
cord-261532-q923xxn2	378	97	transactivation	transactivation	NN
cord-261532-q923xxn2	378	98	domain	domain	NN
cord-261532-q923xxn2	378	99	;	;	:
cord-261532-q923xxn2	378	100	TAK1	TAK1	NNP
cord-261532-q923xxn2	378	101	,	,	,
cord-261532-q923xxn2	378	102	(	(	-LRB-
cord-261532-q923xxn2	378	103	TFG	TFG	NNP
cord-261532-q923xxn2	378	104	-	-	HYPH
cord-261532-q923xxn2	378	105	β)-activated	β)-activate	VBN
cord-261532-q923xxn2	378	106	kinase	kinase	NN
cord-261532-q923xxn2	378	107	1	1	CD
cord-261532-q923xxn2	378	108	;	;	:
cord-261532-q923xxn2	378	109	TBK1	TBK1	NNP
cord-261532-q923xxn2	378	110	,	,	,
cord-261532-q923xxn2	378	111	TRAF	TRAF	NNP
cord-261532-q923xxn2	378	112	family	family	NN
cord-261532-q923xxn2	378	113	member	member	NN
cord-261532-q923xxn2	378	114	-	-	HYPH
cord-261532-q923xxn2	378	115	associated	associate	VBN
cord-261532-q923xxn2	378	116	NF	nf	NN
cord-261532-q923xxn2	378	117	-	-	HYPH
cord-261532-q923xxn2	378	118	κB	κb	CD
cord-261532-q923xxn2	378	119	activator	activator	NN
cord-261532-q923xxn2	378	120	(	(	-LRB-
cord-261532-q923xxn2	378	121	TANK)-binding	tank)-binde	VBG
cord-261532-q923xxn2	378	122	kinase	kinase	NN
cord-261532-q923xxn2	378	123	;	;	:
cord-261532-q923xxn2	378	124	TGF	TGF	NNP
cord-261532-q923xxn2	378	125	-	-	HYPH
cord-261532-q923xxn2	378	126	β	β	NNP
cord-261532-q923xxn2	378	127	,	,	,
cord-261532-q923xxn2	378	128	transforming	transform	VBG
cord-261532-q923xxn2	378	129	growth	growth	NN
cord-261532-q923xxn2	378	130	factor	factor	NN
cord-261532-q923xxn2	378	131	β	β	NN
cord-261532-q923xxn2	378	132	;	;	:
cord-261532-q923xxn2	378	133	TICAM-1	TICAM-1	NNP
cord-261532-q923xxn2	378	134	,	,	,
cord-261532-q923xxn2	378	135	TRIF	TRIF	NNP
cord-261532-q923xxn2	378	136	/	/	SYM
cord-261532-q923xxn2	378	137	TIR	TIR	NNP
cord-261532-q923xxn2	378	138	domain	domain	NN
cord-261532-q923xxn2	378	139	-	-	HYPH
cord-261532-q923xxn2	378	140	containing	contain	VBG
cord-261532-q923xxn2	378	141	adaptor	adaptor	NN
cord-261532-q923xxn2	378	142	molecule	molecule	NN
cord-261532-q923xxn2	378	143	1	1	CD
cord-261532-q923xxn2	378	144	;	;	:
cord-261532-q923xxn2	378	145	TIR	TIR	NNP
cord-261532-q923xxn2	378	146	,	,	,
cord-261532-q923xxn2	378	147	Toll	Toll	NNP
cord-261532-q923xxn2	378	148	/	/	SYM
cord-261532-q923xxn2	378	149	interleukin-1	interleukin-1	NN
cord-261532-q923xxn2	378	150	receptor	receptor	NN
cord-261532-q923xxn2	378	151	;	;	:
cord-261532-q923xxn2	378	152	Th2	Th2	NNP
cord-261532-q923xxn2	378	153	,	,	,
cord-261532-q923xxn2	378	154	T	t	NN
cord-261532-q923xxn2	378	155	-	-	HYPH
cord-261532-q923xxn2	378	156	helper	helper	NN
cord-261532-q923xxn2	378	157	type	type	NN
cord-261532-q923xxn2	378	158	2	2	CD
cord-261532-q923xxn2	378	159	;	;	:
cord-261532-q923xxn2	378	160	TNF	TNF	NNP
cord-261532-q923xxn2	378	161	,	,	,
cord-261532-q923xxn2	378	162	tumor	tumor	NN
cord-261532-q923xxn2	378	163	necrosis	necrosis	NN
cord-261532-q923xxn2	378	164	factor	factor	NN
cord-261532-q923xxn2	378	165	;	;	:
cord-261532-q923xxn2	378	166	TRAM	tram	NN
cord-261532-q923xxn2	378	167	,	,	,
cord-261532-q923xxn2	378	168	TRIF	TRIF	NNP
cord-261532-q923xxn2	378	169	-	-	HYPH
cord-261532-q923xxn2	378	170	related	relate	VBN
cord-261532-q923xxn2	378	171	adaptor	adaptor	NN
cord-261532-q923xxn2	378	172	molecule	molecule	NN
cord-261532-q923xxn2	378	173	;	;	:
cord-261532-q923xxn2	378	174	TRADD	TRADD	NNP
cord-261532-q923xxn2	378	175	,	,	,
cord-261532-q923xxn2	378	176	TNFR	TNFR	NNP
cord-261532-q923xxn2	378	177	-	-	HYPH
cord-261532-q923xxn2	378	178	associated	associate	VBN
cord-261532-q923xxn2	378	179	death	death	NN
cord-261532-q923xxn2	378	180	domain	domain	NN
cord-261532-q923xxn2	378	181	protein	protein	NN
cord-261532-q923xxn2	378	182	;	;	:
cord-261532-q923xxn2	378	183	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	378	184	,	,	,
cord-261532-q923xxn2	378	185	(	(	-LRB-
cord-261532-q923xxn2	378	186	TNF)R	TNF)R	NNP
cord-261532-q923xxn2	378	187	-	-	HYPH
cord-261532-q923xxn2	378	188	associated	associate	VBN
cord-261532-q923xxn2	378	189	factor	factor	NN
cord-261532-q923xxn2	378	190	6	6	CD
cord-261532-q923xxn2	378	191	;	;	:
cord-261532-q923xxn2	378	192	TRAP	trap	NN
cord-261532-q923xxn2	378	193	,	,	,
cord-261532-q923xxn2	378	194	translocon	translocon	NNP
cord-261532-q923xxn2	378	195	associated	associate	VBD
cord-261532-q923xxn2	378	196	protein	protein	NN
cord-261532-q923xxn2	378	197	;	;	:
cord-261532-q923xxn2	378	198	TRIF	TRIF	NNP
cord-261532-q923xxn2	378	199	,	,	,
cord-261532-q923xxn2	378	200	TIR	TIR	NNP
cord-261532-q923xxn2	378	201	domain	domain	NN
cord-261532-q923xxn2	378	202	-	-	HYPH
cord-261532-q923xxn2	378	203	containing	contain	VBG
cord-261532-q923xxn2	378	204	adaptor	adaptor	NN
cord-261532-q923xxn2	378	205	inducing	induce	VBG
cord-261532-q923xxn2	378	206	IFN	IFN	NNP
cord-261532-q923xxn2	378	207	-	-	HYPH
cord-261532-q923xxn2	378	208	β	β	NNP
cord-261532-q923xxn2	378	209	;	;	:
cord-261532-q923xxn2	378	210	VISA	VISA	NNP
cord-261532-q923xxn2	378	211	,	,	,
cord-261532-q923xxn2	378	212	virus	virus	NN
cord-261532-q923xxn2	378	213	-	-	HYPH
cord-261532-q923xxn2	378	214	induced	induce	VBN
cord-261532-q923xxn2	378	215	signaling	signal	VBG
cord-261532-q923xxn2	378	216	adaptor	adaptor	NN
cord-261532-q923xxn2	378	217	;	;	:
cord-261532-q923xxn2	378	218	VSV	VSV	NNP
cord-261532-q923xxn2	378	219	,	,	,
cord-261532-q923xxn2	378	220	vesicular	vesicular	JJ
cord-261532-q923xxn2	378	221	stomatitis	stomatitis	NN
cord-261532-q923xxn2	378	222	virus	virus	NN
cord-261532-q923xxn2	378	223	;	;	:
cord-261532-q923xxn2	378	224	Negative	negative	JJ
cord-261532-q923xxn2	378	225	regulation	regulation	NN
cord-261532-q923xxn2	378	226	of	of	IN
cord-261532-q923xxn2	378	227	the	the	DT
cord-261532-q923xxn2	378	228	RIG	rig	NN
cord-261532-q923xxn2	378	229	-	-	:
cord-261532-q923xxn2	378	230	I	i	NN
cord-261532-q923xxn2	378	231	signaling	signal	VBG
cord-261532-q923xxn2	378	232	by	by	IN
cord-261532-q923xxn2	378	233	the	the	DT
cord-261532-q923xxn2	378	234	ubiquitin	ubiquitin	NN
cord-261532-q923xxn2	378	235	ligase	ligase	NN
cord-261532-q923xxn2	378	236	RNF125	RNF125	NNP
cord-261532-q923xxn2	378	237	Innate	innate	JJ
cord-261532-q923xxn2	378	238	immune	immune	JJ
cord-261532-q923xxn2	378	239	DNA	dna	NN
cord-261532-q923xxn2	378	240	sensing	sensing	NN
cord-261532-q923xxn2	378	241	pathways	pathway	NNS
cord-261532-q923xxn2	378	242	:	:	:
cord-261532-q923xxn2	378	243	STING	sting	VB
cord-261532-q923xxn2	378	244	,	,	,
cord-261532-q923xxn2	378	245	AIMII	AIMII	NNP
cord-261532-q923xxn2	378	246	and	and	CC
cord-261532-q923xxn2	378	247	the	the	DT
cord-261532-q923xxn2	378	248	regulation	regulation	NN
cord-261532-q923xxn2	378	249	of	of	IN
cord-261532-q923xxn2	378	250	interferon	interferon	NN
cord-261532-q923xxn2	378	251	production	production	NN
cord-261532-q923xxn2	378	252	and	and	CC
cord-261532-q923xxn2	378	253	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	378	254	responses	response	NNS
cord-261532-q923xxn2	379	1	Increased	increase	VBN
cord-261532-q923xxn2	379	2	expression	expression	NN
cord-261532-q923xxn2	379	3	of	of	IN
cord-261532-q923xxn2	379	4	eotaxin-3	eotaxin-3	NNP
cord-261532-q923xxn2	379	5	distinguishes	distinguishe	NNS
cord-261532-q923xxn2	379	6	between	between	IN
cord-261532-q923xxn2	379	7	eosinophilic	eosinophilic	JJ
cord-261532-q923xxn2	379	8	esophagitis	esophagitis	NN
cord-261532-q923xxn2	379	9	and	and	CC
cord-261532-q923xxn2	379	10	gastroesophageal	gastroesophageal	JJ
cord-261532-q923xxn2	379	11	reflux	reflux	NN
cord-261532-q923xxn2	379	12	disease	disease	NN
cord-261532-q923xxn2	379	13	Stats	stat	NNS
cord-261532-q923xxn2	379	14	:	:	:
cord-261532-q923xxn2	379	15	multifaceted	multifaceted	JJ
cord-261532-q923xxn2	379	16	regulators	regulator	NNS
cord-261532-q923xxn2	379	17	of	of	IN
cord-261532-q923xxn2	379	18	transcription	transcription	NN
cord-261532-q923xxn2	379	19	TLR	tlr	NN
cord-261532-q923xxn2	379	20	-	-	HYPH
cord-261532-q923xxn2	379	21	signaling	signal	VBG
cord-261532-q923xxn2	379	22	networks	network	NNS
cord-261532-q923xxn2	379	23	:	:	:
cord-261532-q923xxn2	379	24	an	an	DT
cord-261532-q923xxn2	379	25	integration	integration	NN
cord-261532-q923xxn2	379	26	of	of	IN
cord-261532-q923xxn2	379	27	adaptor	adaptor	NN
cord-261532-q923xxn2	379	28	molecules	molecule	NNS
cord-261532-q923xxn2	379	29	,	,	,
cord-261532-q923xxn2	379	30	kinases	kinase	NNS
cord-261532-q923xxn2	379	31	,	,	,
cord-261532-q923xxn2	379	32	and	and	CC
cord-261532-q923xxn2	379	33	cross	cross	NN
cord-261532-q923xxn2	379	34	-	-	NN
cord-261532-q923xxn2	379	35	talk	talk	NN
cord-261532-q923xxn2	380	1	An	an	DT
cord-261532-q923xxn2	380	2	orthogonal	orthogonal	JJ
cord-261532-q923xxn2	380	3	proteomic	proteomic	JJ
cord-261532-q923xxn2	380	4	-	-	HYPH
cord-261532-q923xxn2	380	5	genomic	genomic	JJ
cord-261532-q923xxn2	380	6	screen	screen	NN
cord-261532-q923xxn2	380	7	identifies	identify	VBZ
cord-261532-q923xxn2	380	8	AIM2	AIM2	NNP
cord-261532-q923xxn2	380	9	as	as	IN
cord-261532-q923xxn2	380	10	a	a	DT
cord-261532-q923xxn2	380	11	cytoplasmic	cytoplasmic	JJ
cord-261532-q923xxn2	380	12	DNA	dna	NN
cord-261532-q923xxn2	380	13	sensor	sensor	NN
cord-261532-q923xxn2	380	14	for	for	IN
cord-261532-q923xxn2	380	15	the	the	DT
cord-261532-q923xxn2	380	16	inflammasome	inflammasome	NN
cord-261532-q923xxn2	380	17	IRAK	IRAK	NNP
cord-261532-q923xxn2	380	18	:	:	:
cord-261532-q923xxn2	381	1	a	a	DT
cord-261532-q923xxn2	381	2	kinase	kinase	NN
cord-261532-q923xxn2	381	3	associated	associate	VBN
cord-261532-q923xxn2	381	4	with	with	IN
cord-261532-q923xxn2	381	5	the	the	DT
cord-261532-q923xxn2	381	6	interleukin-1	interleukin-1	NNP
cord-261532-q923xxn2	381	7	receptor	receptor	NN
cord-261532-q923xxn2	381	8	Regulation	regulation	NN
cord-261532-q923xxn2	381	9	of	of	IN
cord-261532-q923xxn2	381	10	the	the	DT
cord-261532-q923xxn2	381	11	T	T	NNP
cord-261532-q923xxn2	381	12	helper	helper	NN
cord-261532-q923xxn2	381	13	cell	cell	NN
cord-261532-q923xxn2	381	14	type	type	NN
cord-261532-q923xxn2	381	15	2	2	CD
cord-261532-q923xxn2	381	16	(	(	-LRB-
cord-261532-q923xxn2	381	17	Th2)/T	Th2)/T	NNP
cord-261532-q923xxn2	381	18	regulatory	regulatory	JJ
cord-261532-q923xxn2	381	19	cell	cell	NN
cord-261532-q923xxn2	381	20	(	(	-LRB-
cord-261532-q923xxn2	381	21	Treg	Treg	NNP
cord-261532-q923xxn2	381	22	)	)	-RRB-
cord-261532-q923xxn2	381	23	balance	balance	NN
cord-261532-q923xxn2	381	24	by	by	IN
cord-261532-q923xxn2	381	25	IL-4	IL-4	NNP
cord-261532-q923xxn2	381	26	and	and	CC
cord-261532-q923xxn2	381	27	STAT6	STAT6	NNP
cord-261532-q923xxn2	381	28	Activation	activation	NN
cord-261532-q923xxn2	381	29	of	of	IN
cord-261532-q923xxn2	381	30	STAT6	stat6	NN
cord-261532-q923xxn2	381	31	by	by	IN
cord-261532-q923xxn2	381	32	STING	STING	NNP
cord-261532-q923xxn2	381	33	is	be	VBZ
cord-261532-q923xxn2	381	34	critical	critical	JJ
cord-261532-q923xxn2	381	35	for	for	IN
cord-261532-q923xxn2	381	36	antiviral	antiviral	JJ
cord-261532-q923xxn2	381	37	innate	innate	JJ
cord-261532-q923xxn2	381	38	immunity	immunity	NN
cord-261532-q923xxn2	381	39	Ubiquitin	Ubiquitin	NNP
cord-261532-q923xxn2	381	40	signalling	signal	VBG
cord-261532-q923xxn2	381	41	in	in	IN
cord-261532-q923xxn2	381	42	the	the	DT
cord-261532-q923xxn2	381	43	NF	nf	NN
cord-261532-q923xxn2	381	44	-	-	HYPH
cord-261532-q923xxn2	381	45	κB	κB	NNP
cord-261532-q923xxn2	381	46	pathway	pathway	NN
cord-261532-q923xxn2	382	1	Systematic	systematic	JJ
cord-261532-q923xxn2	382	2	discovery	discovery	NN
cord-261532-q923xxn2	382	3	of	of	IN
cord-261532-q923xxn2	382	4	TLR	TLR	NNP
cord-261532-q923xxn2	382	5	signaling	signal	VBG
cord-261532-q923xxn2	382	6	components	component	NNS
cord-261532-q923xxn2	382	7	delineates	delineate	VBZ
cord-261532-q923xxn2	382	8	viral	viral	JJ
cord-261532-q923xxn2	382	9	-	-	HYPH
cord-261532-q923xxn2	382	10	sensing	sense	VBG
cord-261532-q923xxn2	382	11	circuits	circuit	NNS
cord-261532-q923xxn2	382	12	Peroxisomes	Peroxisomes	NNPS
cord-261532-q923xxn2	382	13	are	be	VBP
cord-261532-q923xxn2	382	14	signaling	signal	VBG
cord-261532-q923xxn2	382	15	platforms	platform	NNS
cord-261532-q923xxn2	382	16	for	for	IN
cord-261532-q923xxn2	383	1	antiviral	antiviral	JJ
cord-261532-q923xxn2	383	2	innate	innate	JJ
cord-261532-q923xxn2	383	3	immunity	immunity	NN
cord-261532-q923xxn2	383	4	AIM2	AIM2	NNP
cord-261532-q923xxn2	383	5	activates	activate	VBZ
cord-261532-q923xxn2	383	6	the	the	DT
cord-261532-q923xxn2	383	7	inflammasome	inflammasome	NN
cord-261532-q923xxn2	383	8	and	and	CC
cord-261532-q923xxn2	383	9	cell	cell	NN
cord-261532-q923xxn2	383	10	death	death	NN
cord-261532-q923xxn2	383	11	in	in	IN
cord-261532-q923xxn2	383	12	response	response	NN
cord-261532-q923xxn2	383	13	to	to	IN
cord-261532-q923xxn2	383	14	cytoplasmic	cytoplasmic	JJ
cord-261532-q923xxn2	383	15	DNA	DNA	NNP
cord-261532-q923xxn2	383	16	Specificity	Specificity	NNP
cord-261532-q923xxn2	383	17	in	in	IN
cord-261532-q923xxn2	383	18	Toll	Toll	NNP
cord-261532-q923xxn2	383	19	-	-	HYPH
cord-261532-q923xxn2	383	20	like	like	JJ
cord-261532-q923xxn2	383	21	receptor	receptor	NN
cord-261532-q923xxn2	383	22	signalling	signal	VBG
cord-261532-q923xxn2	383	23	through	through	IN
cord-261532-q923xxn2	383	24	distinct	distinct	JJ
cord-261532-q923xxn2	383	25	effector	effector	NN
cord-261532-q923xxn2	383	26	functions	function	NNS
cord-261532-q923xxn2	383	27	of	of	IN
cord-261532-q923xxn2	383	28	TRAF3	traf3	NN
cord-261532-q923xxn2	383	29	and	and	CC
cord-261532-q923xxn2	383	30	TRAF6	TRAF6	NNP
cord-261532-q923xxn2	383	31	Signaling	signaling	NN
cord-261532-q923xxn2	383	32	mechanisms	mechanism	NNS
cord-261532-q923xxn2	383	33	,	,	,
cord-261532-q923xxn2	383	34	interaction	interaction	NN
cord-261532-q923xxn2	383	35	partners	partner	NNS
cord-261532-q923xxn2	383	36	,	,	,
cord-261532-q923xxn2	383	37	and	and	CC
cord-261532-q923xxn2	383	38	target	target	VB
cord-261532-q923xxn2	383	39	genes	gene	NNS
cord-261532-q923xxn2	383	40	of	of	IN
cord-261532-q923xxn2	383	41	STAT6	stat6	NN
cord-261532-q923xxn2	384	1	STAT6	STAT6	NNP
cord-261532-q923xxn2	384	2	mediates	mediate	VBZ
cord-261532-q923xxn2	384	3	eotaxin-1	eotaxin-1	NNP
cord-261532-q923xxn2	384	4	expression	expression	NN
cord-261532-q923xxn2	384	5	in	in	IN
cord-261532-q923xxn2	384	6	IL-4	IL-4	NNP
cord-261532-q923xxn2	384	7	or	or	CC
cord-261532-q923xxn2	385	1	TNF	tnf	NN
cord-261532-q923xxn2	385	2	-	-	HYPH
cord-261532-q923xxn2	385	3	alpha	alpha	NN
cord-261532-q923xxn2	385	4	-	-	HYPH
cord-261532-q923xxn2	385	5	induced	induce	VBN
cord-261532-q923xxn2	385	6	fibroblasts	fibroblasts	NN
cord-261532-q923xxn2	385	7	TIRAP	TIRAP	NNP
cord-261532-q923xxn2	385	8	:	:	:
cord-261532-q923xxn2	386	1	an	an	DT
cord-261532-q923xxn2	386	2	adaptor	adaptor	NN
cord-261532-q923xxn2	386	3	molecule	molecule	NN
cord-261532-q923xxn2	386	4	in	in	IN
cord-261532-q923xxn2	386	5	the	the	DT
cord-261532-q923xxn2	386	6	Toll	toll	NN
cord-261532-q923xxn2	386	7	signaling	signal	VBG
cord-261532-q923xxn2	386	8	pathway	pathway	NN
cord-261532-q923xxn2	386	9	AIM2	AIM2	NNP
cord-261532-q923xxn2	386	10	recognizes	recognize	VBZ
cord-261532-q923xxn2	386	11	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	386	12	dsDNA	dsdna	RB
cord-261532-q923xxn2	386	13	and	and	CC
cord-261532-q923xxn2	386	14	forms	form	VBZ
cord-261532-q923xxn2	386	15	a	a	DT
cord-261532-q923xxn2	386	16	caspase-1-activating	caspase-1-activate	VBG
cord-261532-q923xxn2	386	17	inflammasome	inflammasome	NN
cord-261532-q923xxn2	386	18	with	with	IN
cord-261532-q923xxn2	386	19	ASC	ASC	NNP
cord-261532-q923xxn2	387	1	5'-Triphosphate	5'-Triphosphate	NNP
cord-261532-q923xxn2	387	2	RNA	RNA	NNP
cord-261532-q923xxn2	387	3	is	be	VBZ
cord-261532-q923xxn2	387	4	the	the	DT
cord-261532-q923xxn2	387	5	ligand	ligand	NN
cord-261532-q923xxn2	387	6	for	for	IN
cord-261532-q923xxn2	387	7	RIG	rig	NN
cord-261532-q923xxn2	388	1	-I	-I	NFP
cord-261532-q923xxn2	388	2	MAVS	MAVS	NNP
cord-261532-q923xxn2	388	3	forms	form	VBZ
cord-261532-q923xxn2	388	4	functional	functional	JJ
cord-261532-q923xxn2	388	5	prion	prion	NN
cord-261532-q923xxn2	388	6	-	-	HYPH
cord-261532-q923xxn2	388	7	like	like	JJ
cord-261532-q923xxn2	388	8	aggregates	aggregate	NNS
cord-261532-q923xxn2	388	9	to	to	TO
cord-261532-q923xxn2	388	10	activate	activate	VB
cord-261532-q923xxn2	388	11	and	and	CC
cord-261532-q923xxn2	388	12	propagate	propagate	VB
cord-261532-q923xxn2	388	13	antiviral	antiviral	JJ
cord-261532-q923xxn2	388	14	innate	innate	JJ
cord-261532-q923xxn2	388	15	immune	immune	JJ
cord-261532-q923xxn2	388	16	response	response	NN
cord-261532-q923xxn2	388	17	Kit	kit	NN
cord-261532-q923xxn2	388	18	and	and	CC
cord-261532-q923xxn2	388	19	FcepsilonRI	fcepsilonri	NN
cord-261532-q923xxn2	388	20	mediate	mediate	VB
cord-261532-q923xxn2	388	21	unique	unique	JJ
cord-261532-q923xxn2	388	22	and	and	CC
cord-261532-q923xxn2	388	23	convergent	convergent	JJ
cord-261532-q923xxn2	388	24	signals	signal	NNS
cord-261532-q923xxn2	388	25	for	for	IN
cord-261532-q923xxn2	388	26	release	release	NN
cord-261532-q923xxn2	388	27	of	of	IN
cord-261532-q923xxn2	388	28	inflammatory	inflammatory	JJ
cord-261532-q923xxn2	388	29	mediators	mediator	NNS
cord-261532-q923xxn2	388	30	from	from	IN
cord-261532-q923xxn2	388	31	human	human	JJ
cord-261532-q923xxn2	388	32	mast	mast	NN
cord-261532-q923xxn2	388	33	cells	cell	NNS
cord-261532-q923xxn2	388	34	STING	sting	VBP
cord-261532-q923xxn2	388	35	regulates	regulate	VBZ
cord-261532-q923xxn2	388	36	intracellular	intracellular	JJ
cord-261532-q923xxn2	388	37	DNA	dna	NN
cord-261532-q923xxn2	388	38	-	-	HYPH
cord-261532-q923xxn2	388	39	mediated	mediate	VBN
cord-261532-q923xxn2	388	40	,	,	,
cord-261532-q923xxn2	388	41	type	type	NN
cord-261532-q923xxn2	388	42	I	-PRON-	PRP
cord-261532-q923xxn2	388	43	interferon	interferon	NN
cord-261532-q923xxn2	388	44	-	-	HYPH
cord-261532-q923xxn2	388	45	dependent	dependent	JJ
cord-261532-q923xxn2	388	46	innate	innate	JJ
cord-261532-q923xxn2	388	47	immunity	immunity	NN
cord-261532-q923xxn2	389	1	Ubiquitin	Ubiquitin	NNP
cord-261532-q923xxn2	389	2	-	-	HYPH
cord-261532-q923xxn2	389	3	induced	induce	VBN
cord-261532-q923xxn2	389	4	oligomerization	oligomerization	NN
cord-261532-q923xxn2	389	5	of	of	IN
cord-261532-q923xxn2	389	6	the	the	DT
cord-261532-q923xxn2	389	7	RNA	RNA	NNP
cord-261532-q923xxn2	389	8	sensors	sensor	NNS
cord-261532-q923xxn2	389	9	RIG	rig	NN
cord-261532-q923xxn2	389	10	-	-	:
cord-261532-q923xxn2	389	11	I	I	NNP
cord-261532-q923xxn2	389	12	and	and	CC
cord-261532-q923xxn2	389	13	Mda5	Mda5	NNP
cord-261532-q923xxn2	389	14	activates	activate	VBZ
cord-261532-q923xxn2	389	15	antiviral	antiviral	JJ
cord-261532-q923xxn2	389	16	innate	innate	JJ
cord-261532-q923xxn2	389	17	immune	immune	JJ
cord-261532-q923xxn2	389	18	response	response	NN
cord-261532-q923xxn2	389	19	Differential	differential	JJ
cord-261532-q923xxn2	389	20	roles	role	NNS
cord-261532-q923xxn2	389	21	of	of	IN
cord-261532-q923xxn2	389	22	MDA5	MDA5	NNP
cord-261532-q923xxn2	389	23	and	and	CC
cord-261532-q923xxn2	389	24	RIG	rig	NN
cord-261532-q923xxn2	390	1	-I	-i	DT
cord-261532-q923xxn2	390	2	helicases	helicase	NNS
cord-261532-q923xxn2	390	3	in	in	IN
cord-261532-q923xxn2	390	4	the	the	DT
cord-261532-q923xxn2	390	5	recognition	recognition	NN
cord-261532-q923xxn2	390	6	of	of	IN
cord-261532-q923xxn2	390	7	RNA	RNA	NNP
cord-261532-q923xxn2	390	8	viruses	virus	NNS
cord-261532-q923xxn2	390	9	Unresponsiveness	Unresponsiveness	NNP
cord-261532-q923xxn2	390	10	of	of	IN
cord-261532-q923xxn2	390	11	MyD88-deficient	MyD88-deficient	NNP
cord-261532-q923xxn2	390	12	mice	mouse	NNS
cord-261532-q923xxn2	390	13	to	to	TO
cord-261532-q923xxn2	390	14	endotoxin	endotoxin	VB
cord-261532-q923xxn2	390	15	IPS-1	IPS-1	NNP
cord-261532-q923xxn2	390	16	,	,	,
cord-261532-q923xxn2	390	17	an	an	DT
cord-261532-q923xxn2	390	18	adaptor	adaptor	NN
cord-261532-q923xxn2	390	19	triggering	trigger	VBG
cord-261532-q923xxn2	390	20	RIG	rig	NN
cord-261532-q923xxn2	390	21	-	-	HYPH
cord-261532-q923xxn2	390	22	I	i	NN
cord-261532-q923xxn2	390	23	-	-	HYPH
cord-261532-q923xxn2	390	24	and	and	CC
cord-261532-q923xxn2	390	25	Mda5-mediated	Mda5-mediated	NNP
cord-261532-q923xxn2	391	1	type	type	NN
cord-261532-q923xxn2	391	2	I	-PRON-	PRP
cord-261532-q923xxn2	391	3	interferon	interferon	VBD
cord-261532-q923xxn2	391	4	induction	induction	NN
cord-261532-q923xxn2	392	1	Innate	innate	JJ
cord-261532-q923xxn2	392	2	immune	immune	JJ
cord-261532-q923xxn2	392	3	recognition	recognition	NN
cord-261532-q923xxn2	392	4	of	of	IN
cord-261532-q923xxn2	392	5	bacterial	bacterial	JJ
cord-261532-q923xxn2	392	6	ligands	ligand	NNS
cord-261532-q923xxn2	392	7	by	by	IN
cord-261532-q923xxn2	392	8	NAIPs	naip	NNS
cord-261532-q923xxn2	392	9	determines	determine	VBZ
cord-261532-q923xxn2	392	10	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	392	11	specificity	specificity	NN
cord-261532-q923xxn2	392	12	Pathogen	Pathogen	NNP
cord-261532-q923xxn2	392	13	recognition	recognition	NN
cord-261532-q923xxn2	392	14	by	by	IN
cord-261532-q923xxn2	392	15	the	the	DT
cord-261532-q923xxn2	392	16	innate	innate	JJ
cord-261532-q923xxn2	392	17	immune	immune	JJ
cord-261532-q923xxn2	392	18	system	system	NN
cord-261532-q923xxn2	393	1	Signaling	signal	VBG
cord-261532-q923xxn2	393	2	pathways	pathway	NNS
cord-261532-q923xxn2	393	3	downstream	downstream	RB
cord-261532-q923xxn2	393	4	of	of	IN
cord-261532-q923xxn2	393	5	pattern	pattern	NN
cord-261532-q923xxn2	393	6	-	-	HYPH
cord-261532-q923xxn2	393	7	recognition	recognition	NN
cord-261532-q923xxn2	393	8	receptors	receptor	NNS
cord-261532-q923xxn2	393	9	and	and	CC
cord-261532-q923xxn2	393	10	their	-PRON-	PRP$
cord-261532-q923xxn2	393	11	cross	cross	NN
cord-261532-q923xxn2	393	12	talk	talk	NN
cord-261532-q923xxn2	393	13	The	the	DT
cord-261532-q923xxn2	393	14	role	role	NN
cord-261532-q923xxn2	393	15	of	of	IN
cord-261532-q923xxn2	393	16	MCP-1	MCP-1	NNP
cord-261532-q923xxn2	393	17	(	(	-LRB-
cord-261532-q923xxn2	393	18	CCL2	CCL2	NNP
cord-261532-q923xxn2	393	19	)	)	-RRB-
cord-261532-q923xxn2	393	20	and	and	CC
cord-261532-q923xxn2	393	21	CCR2	CCR2	NNP
cord-261532-q923xxn2	393	22	in	in	IN
cord-261532-q923xxn2	393	23	multiple	multiple	JJ
cord-261532-q923xxn2	393	24	sclerosis	sclerosis	NN
cord-261532-q923xxn2	393	25	and	and	CC
cord-261532-q923xxn2	393	26	experimental	experimental	JJ
cord-261532-q923xxn2	393	27	autoimmune	autoimmune	JJ
cord-261532-q923xxn2	393	28	encephalomyelitis	encephalomyelitis	NN
cord-261532-q923xxn2	393	29	(	(	-LRB-
cord-261532-q923xxn2	394	1	EAE	EAE	NNP
cord-261532-q923xxn2	394	2	)	)	-RRB-
cord-261532-q923xxn2	394	3	IRAK	IRAK	NNP
cord-261532-q923xxn2	395	1	(	(	-LRB-
cord-261532-q923xxn2	395	2	Pelle	Pelle	NNP
cord-261532-q923xxn2	395	3	)	)	-RRB-
cord-261532-q923xxn2	395	4	Family	Family	NNP
cord-261532-q923xxn2	395	5	Member	Member	NNP
cord-261532-q923xxn2	395	6	IRAK-2	IRAK-2	NNP
cord-261532-q923xxn2	395	7	AND	and	CC
cord-261532-q923xxn2	395	8	MyD88	MyD88	NNP
cord-261532-q923xxn2	395	9	as	as	IN
cord-261532-q923xxn2	395	10	Proximal	Proximal	NNP
cord-261532-q923xxn2	395	11	Mediators	Mediators	NNPS
cord-261532-q923xxn2	395	12	of	of	IN
cord-261532-q923xxn2	395	13	IL-1	IL-1	NNP
cord-261532-q923xxn2	395	14	Signaling	Signaling	NNP
cord-261532-q923xxn2	395	15	Cardif	Cardif	NNP
cord-261532-q923xxn2	395	16	is	be	VBZ
cord-261532-q923xxn2	395	17	an	an	DT
cord-261532-q923xxn2	395	18	adaptor	adaptor	NN
cord-261532-q923xxn2	395	19	protein	protein	NN
cord-261532-q923xxn2	395	20	in	in	IN
cord-261532-q923xxn2	395	21	the	the	DT
cord-261532-q923xxn2	395	22	RIG	rig	NN
cord-261532-q923xxn2	395	23	-	-	:
cord-261532-q923xxn2	395	24	I	I	NNP
cord-261532-q923xxn2	395	25	antiviral	antiviral	JJ
cord-261532-q923xxn2	395	26	pathway	pathway	NN
cord-261532-q923xxn2	395	27	and	and	CC
cord-261532-q923xxn2	395	28	is	be	VBZ
cord-261532-q923xxn2	395	29	targeted	target	VBN
cord-261532-q923xxn2	395	30	by	by	IN
cord-261532-q923xxn2	395	31	hepatitis	hepatitis	NN
cord-261532-q923xxn2	395	32	C	C	NNP
cord-261532-q923xxn2	395	33	virus	virus	NN
cord-261532-q923xxn2	396	1	NLRX1	NLRX1	NNP
cord-261532-q923xxn2	396	2	is	be	VBZ
cord-261532-q923xxn2	396	3	a	a	DT
cord-261532-q923xxn2	396	4	regulator	regulator	NN
cord-261532-q923xxn2	396	5	of	of	IN
cord-261532-q923xxn2	396	6	mitochondrial	mitochondrial	JJ
cord-261532-q923xxn2	396	7	antiviral	antiviral	JJ
cord-261532-q923xxn2	396	8	immunity	immunity	NN
cord-261532-q923xxn2	396	9	Eotaxin-3	Eotaxin-3	NNP
cord-261532-q923xxn2	396	10	/	/	SYM
cord-261532-q923xxn2	396	11	CC	cc	NN
cord-261532-q923xxn2	396	12	chemokine	chemokine	NN
cord-261532-q923xxn2	396	13	ligand	ligand	NN
cord-261532-q923xxn2	396	14	26	26	CD
cord-261532-q923xxn2	397	1	is	be	VBZ
cord-261532-q923xxn2	397	2	a	a	DT
cord-261532-q923xxn2	397	3	functional	functional	JJ
cord-261532-q923xxn2	397	4	ligand	ligand	NN
cord-261532-q923xxn2	397	5	for	for	IN
cord-261532-q923xxn2	397	6	CX3CR1	CX3CR1	NNP
cord-261532-q923xxn2	397	7	Tissue	tissue	NN
cord-261532-q923xxn2	397	8	-	-	HYPH
cord-261532-q923xxn2	397	9	specific	specific	JJ
cord-261532-q923xxn2	397	10	mRNA	mrna	NN
cord-261532-q923xxn2	397	11	expression	expression	NN
cord-261532-q923xxn2	397	12	profiles	profile	NNS
cord-261532-q923xxn2	397	13	of	of	IN
cord-261532-q923xxn2	397	14	human	human	JJ
cord-261532-q923xxn2	397	15	toll	toll	NN
cord-261532-q923xxn2	397	16	-	-	HYPH
cord-261532-q923xxn2	397	17	like	like	JJ
cord-261532-q923xxn2	397	18	receptors	receptor	NNS
cord-261532-q923xxn2	397	19	and	and	CC
cord-261532-q923xxn2	397	20	related	relate	VBN
cord-261532-q923xxn2	397	21	genes	gene	NNS
cord-261532-q923xxn2	397	22	Regulation	Regulation	NNP
cord-261532-q923xxn2	397	23	of	of	IN
cord-261532-q923xxn2	397	24	the	the	DT
cord-261532-q923xxn2	397	25	innate	innate	JJ
cord-261532-q923xxn2	397	26	immune	immune	JJ
cord-261532-q923xxn2	397	27	response	response	NN
cord-261532-q923xxn2	397	28	by	by	IN
cord-261532-q923xxn2	397	29	threonine	threonine	NN
cord-261532-q923xxn2	397	30	-	-	HYPH
cord-261532-q923xxn2	397	31	phosphatase	phosphatase	NN
cord-261532-q923xxn2	397	32	of	of	IN
cord-261532-q923xxn2	397	33	Eyes	eye	NNS
cord-261532-q923xxn2	397	34	absent	absent	JJ
cord-261532-q923xxn2	397	35	Activation	activation	NN
cord-261532-q923xxn2	397	36	of	of	IN
cord-261532-q923xxn2	397	37	the	the	DT
cord-261532-q923xxn2	397	38	NALP3	NALP3	NNP
cord-261532-q923xxn2	397	39	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	397	40	is	be	VBZ
cord-261532-q923xxn2	397	41	triggered	trigger	VBN
cord-261532-q923xxn2	397	42	by	by	IN
cord-261532-q923xxn2	397	43	low	low	JJ
cord-261532-q923xxn2	397	44	intracellular	intracellular	JJ
cord-261532-q923xxn2	397	45	potassium	potassium	NN
cord-261532-q923xxn2	397	46	concentration	concentration	NN
cord-261532-q923xxn2	398	1	The	the	DT
cord-261532-q923xxn2	398	2	RNA	RNA	NNP
cord-261532-q923xxn2	398	3	helicase	helicase	NN
cord-261532-q923xxn2	398	4	Lgp2	Lgp2	NNP
cord-261532-q923xxn2	398	5	inhibits	inhibit	VBZ
cord-261532-q923xxn2	398	6	TLR	TLR	NNP
cord-261532-q923xxn2	398	7	-	-	HYPH
cord-261532-q923xxn2	398	8	independent	independent	JJ
cord-261532-q923xxn2	398	9	sensing	sensing	NN
cord-261532-q923xxn2	398	10	of	of	IN
cord-261532-q923xxn2	398	11	viral	viral	JJ
cord-261532-q923xxn2	398	12	replication	replication	NN
cord-261532-q923xxn2	398	13	by	by	IN
cord-261532-q923xxn2	398	14	retinoic	retinoic	JJ
cord-261532-q923xxn2	398	15	acid	acid	NN
cord-261532-q923xxn2	398	16	-	-	HYPH
cord-261532-q923xxn2	398	17	inducible	inducible	JJ
cord-261532-q923xxn2	398	18	gene-	gene-	NN
cord-261532-q923xxn2	399	1	I	-PRON-	PRP
cord-261532-q923xxn2	399	2	Regulation	regulation	NN
cord-261532-q923xxn2	399	3	of	of	IN
cord-261532-q923xxn2	399	4	innate	innate	JJ
cord-261532-q923xxn2	399	5	antiviral	antiviral	JJ
cord-261532-q923xxn2	399	6	defenses	defense	NNS
cord-261532-q923xxn2	399	7	through	through	IN
cord-261532-q923xxn2	399	8	a	a	DT
cord-261532-q923xxn2	399	9	shared	share	VBN
cord-261532-q923xxn2	399	10	repressor	repressor	NN
cord-261532-q923xxn2	399	11	domain	domain	NN
cord-261532-q923xxn2	399	12	in	in	IN
cord-261532-q923xxn2	399	13	RIG	rig	NN
cord-261532-q923xxn2	399	14	-	-	:
cord-261532-q923xxn2	399	15	I	I	NNP
cord-261532-q923xxn2	399	16	and	and	CC
cord-261532-q923xxn2	399	17	LGP2	LGP2	NNP
cord-261532-q923xxn2	399	18	LGP2	LGP2	NNP
cord-261532-q923xxn2	399	19	is	be	VBZ
cord-261532-q923xxn2	399	20	a	a	DT
cord-261532-q923xxn2	399	21	positive	positive	JJ
cord-261532-q923xxn2	399	22	regulator	regulator	NN
cord-261532-q923xxn2	399	23	of	of	IN
cord-261532-q923xxn2	399	24	RIG	rig	NN
cord-261532-q923xxn2	399	25	-	-	HYPH
cord-261532-q923xxn2	399	26	I	I	NNP
cord-261532-q923xxn2	399	27	-	-	HYPH
cord-261532-q923xxn2	399	28	and	and	CC
cord-261532-q923xxn2	399	29	MDA5-mediated	MDA5-mediated	NNP
cord-261532-q923xxn2	399	30	antiviral	antiviral	JJ
cord-261532-q923xxn2	399	31	responses	response	NNS
cord-261532-q923xxn2	400	1	The	the	DT
cord-261532-q923xxn2	400	2	inflammasomes	inflammasome	NNS
cord-261532-q923xxn2	400	3	IL-4	IL-4	NNP
cord-261532-q923xxn2	400	4	is	be	VBZ
cord-261532-q923xxn2	400	5	a	a	DT
cord-261532-q923xxn2	400	6	critical	critical	JJ
cord-261532-q923xxn2	400	7	determinant	determinant	NN
cord-261532-q923xxn2	400	8	in	in	IN
cord-261532-q923xxn2	400	9	the	the	DT
cord-261532-q923xxn2	400	10	generation	generation	NN
cord-261532-q923xxn2	400	11	of	of	IN
cord-261532-q923xxn2	400	12	allergic	allergic	JJ
cord-261532-q923xxn2	400	13	inflammation	inflammation	NN
cord-261532-q923xxn2	400	14	initiated	initiate	VBN
cord-261532-q923xxn2	400	15	by	by	IN
cord-261532-q923xxn2	400	16	a	a	DT
cord-261532-q923xxn2	400	17	constitutively	constitutively	RB
cord-261532-q923xxn2	400	18	active	active	JJ
cord-261532-q923xxn2	400	19	Stat6	Stat6	.
cord-261532-q923xxn2	400	20	IL-4	IL-4	NNP
cord-261532-q923xxn2	400	21	regulates	regulate	VBZ
cord-261532-q923xxn2	400	22	skin	skin	NN
cord-261532-q923xxn2	400	23	homeostasis	homeostasis	NN
cord-261532-q923xxn2	400	24	and	and	CC
cord-261532-q923xxn2	400	25	the	the	DT
cord-261532-q923xxn2	400	26	predisposition	predisposition	NN
cord-261532-q923xxn2	400	27	toward	toward	IN
cord-261532-q923xxn2	400	28	allergic	allergic	JJ
cord-261532-q923xxn2	400	29	skin	skin	NN
cord-261532-q923xxn2	400	30	inflammation	inflammation	NN
cord-261532-q923xxn2	400	31	Identification	identification	NN
cord-261532-q923xxn2	400	32	and	and	CC
cord-261532-q923xxn2	400	33	characterization	characterization	NN
cord-261532-q923xxn2	400	34	of	of	IN
cord-261532-q923xxn2	400	35	MAVS	MAVS	NNPS
cord-261532-q923xxn2	400	36	,	,	,
cord-261532-q923xxn2	400	37	a	a	DT
cord-261532-q923xxn2	400	38	mitochondrial	mitochondrial	JJ
cord-261532-q923xxn2	400	39	antiviral	antiviral	JJ
cord-261532-q923xxn2	400	40	signaling	signal	VBG
cord-261532-q923xxn2	400	41	protein	protein	NN
cord-261532-q923xxn2	400	42	that	that	WDT
cord-261532-q923xxn2	400	43	activates	activate	VBZ
cord-261532-q923xxn2	401	1	NF	NF	NNP
cord-261532-q923xxn2	401	2	-	-	HYPH
cord-261532-q923xxn2	401	3	κB	κB	NNP
cord-261532-q923xxn2	401	4	and	and	CC
cord-261532-q923xxn2	401	5	IRF	IRF	NNP
cord-261532-q923xxn2	401	6	3	3	CD
cord-261532-q923xxn2	401	7	Coronavirus	Coronavirus	NNP
cord-261532-q923xxn2	401	8	papain	papain	NN
cord-261532-q923xxn2	401	9	-	-	HYPH
cord-261532-q923xxn2	401	10	like	like	JJ
cord-261532-q923xxn2	401	11	proteases	protease	NNS
cord-261532-q923xxn2	401	12	negatively	negatively	RB
cord-261532-q923xxn2	401	13	regulate	regulate	VBP
cord-261532-q923xxn2	401	14	antiviral	antiviral	JJ
cord-261532-q923xxn2	401	15	innate	innate	JJ
cord-261532-q923xxn2	401	16	immune	immune	JJ
cord-261532-q923xxn2	401	17	response	response	NN
cord-261532-q923xxn2	401	18	through	through	IN
cord-261532-q923xxn2	401	19	disruption	disruption	NN
cord-261532-q923xxn2	401	20	of	of	IN
cord-261532-q923xxn2	401	21	STING	sting	NN
cord-261532-q923xxn2	401	22	-	-	HYPH
cord-261532-q923xxn2	401	23	mediated	mediate	VBN
cord-261532-q923xxn2	401	24	signaling	signal	VBG
cord-261532-q923xxn2	401	25	ERIS	ERIS	NNP
cord-261532-q923xxn2	401	26	,	,	,
cord-261532-q923xxn2	401	27	an	an	DT
cord-261532-q923xxn2	401	28	endoplasmic	endoplasmic	NN
cord-261532-q923xxn2	401	29	reticulum	reticulum	NN
cord-261532-q923xxn2	401	30	IFN	IFN	NNP
cord-261532-q923xxn2	401	31	stimulator	stimulator	NN
cord-261532-q923xxn2	401	32	,	,	,
cord-261532-q923xxn2	401	33	activates	activate	VBZ
cord-261532-q923xxn2	401	34	innate	innate	JJ
cord-261532-q923xxn2	401	35	immune	immune	NN
cord-261532-q923xxn2	401	36	signaling	signal	VBG
cord-261532-q923xxn2	401	37	through	through	IN
cord-261532-q923xxn2	401	38	dimerization	dimerization	NN
cord-261532-q923xxn2	401	39	STING	sting	NN
cord-261532-q923xxn2	401	40	specifies	specify	VBZ
cord-261532-q923xxn2	401	41	IRF3	IRF3	NNP
cord-261532-q923xxn2	401	42	phosphorylation	phosphorylation	NN
cord-261532-q923xxn2	401	43	by	by	IN
cord-261532-q923xxn2	401	44	TBK1	TBK1	NNP
cord-261532-q923xxn2	401	45	in	in	IN
cord-261532-q923xxn2	401	46	the	the	DT
cord-261532-q923xxn2	401	47	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	401	48	DNA	dna	NN
cord-261532-q923xxn2	401	49	signaling	signal	VBG
cord-261532-q923xxn2	401	50	pathway	pathway	NN
cord-261532-q923xxn2	401	51	Pattern	pattern	NN
cord-261532-q923xxn2	401	52	recognition	recognition	NN
cord-261532-q923xxn2	401	53	receptors	receptor	NNS
cord-261532-q923xxn2	401	54	and	and	CC
cord-261532-q923xxn2	401	55	inflammation	inflammation	NN
cord-261532-q923xxn2	401	56	Toll	toll	NN
cord-261532-q923xxn2	401	57	-	-	HYPH
cord-261532-q923xxn2	401	58	like	like	JJ
cord-261532-q923xxn2	401	59	receptors	receptor	NNS
cord-261532-q923xxn2	401	60	,	,	,
cord-261532-q923xxn2	401	61	RIG	rig	NN
cord-261532-q923xxn2	401	62	-	-	HYPH
cord-261532-q923xxn2	401	63	I	-PRON-	PRP
cord-261532-q923xxn2	401	64	-	-	HYPH
cord-261532-q923xxn2	401	65	like	like	NNP
cord-261532-q923xxn2	401	66	RNA	RNA	NNP
cord-261532-q923xxn2	401	67	helicases	helicase	NNS
cord-261532-q923xxn2	401	68	and	and	CC
cord-261532-q923xxn2	401	69	the	the	DT
cord-261532-q923xxn2	401	70	antiviral	antiviral	JJ
cord-261532-q923xxn2	401	71	innate	innate	JJ
cord-261532-q923xxn2	401	72	immune	immune	JJ
cord-261532-q923xxn2	401	73	response	response	NN
cord-261532-q923xxn2	402	1	Different	different	JJ
cord-261532-q923xxn2	402	2	modes	mode	NNS
cord-261532-q923xxn2	402	3	of	of	IN
cord-261532-q923xxn2	402	4	ubiquitination	ubiquitination	NN
cord-261532-q923xxn2	402	5	of	of	IN
cord-261532-q923xxn2	402	6	the	the	DT
cord-261532-q923xxn2	402	7	adaptor	adaptor	NN
cord-261532-q923xxn2	402	8	TRAF3	TRAF3	NNP
cord-261532-q923xxn2	402	9	selectively	selectively	RB
cord-261532-q923xxn2	402	10	activate	activate	VBP
cord-261532-q923xxn2	402	11	the	the	DT
cord-261532-q923xxn2	402	12	expression	expression	NN
cord-261532-q923xxn2	402	13	of	of	IN
cord-261532-q923xxn2	402	14	type	type	NN
cord-261532-q923xxn2	402	15	I	-PRON-	PRP
cord-261532-q923xxn2	402	16	interferons	interferon	NNS
cord-261532-q923xxn2	402	17	and	and	CC
cord-261532-q923xxn2	402	18	proinflammatory	proinflammatory	JJ
cord-261532-q923xxn2	402	19	cytokines	cytokine	NNS
cord-261532-q923xxn2	402	20	TLRs	tlr	NNS
cord-261532-q923xxn2	402	21	:	:	:
cord-261532-q923xxn2	402	22	differential	differential	JJ
cord-261532-q923xxn2	402	23	adapter	adapter	NN
cord-261532-q923xxn2	402	24	utilization	utilization	NN
cord-261532-q923xxn2	402	25	by	by	IN
cord-261532-q923xxn2	402	26	toll	toll	NN
cord-261532-q923xxn2	402	27	-	-	HYPH
cord-261532-q923xxn2	402	28	like	like	JJ
cord-261532-q923xxn2	402	29	receptors	receptor	NNS
cord-261532-q923xxn2	402	30	mediates	mediate	VBZ
cord-261532-q923xxn2	402	31	TLR	tlr	NN
cord-261532-q923xxn2	402	32	-	-	HYPH
cord-261532-q923xxn2	402	33	specific	specific	JJ
cord-261532-q923xxn2	402	34	patterns	pattern	NNS
cord-261532-q923xxn2	402	35	of	of	IN
cord-261532-q923xxn2	402	36	gene	gene	NN
cord-261532-q923xxn2	402	37	expression	expression	NN
cord-261532-q923xxn2	402	38	TAK1	TAK1	NNP
cord-261532-q923xxn2	402	39	is	be	VBZ
cord-261532-q923xxn2	402	40	a	a	DT
cord-261532-q923xxn2	402	41	ubiquitin	ubiquitin	NN
cord-261532-q923xxn2	402	42	-	-	HYPH
cord-261532-q923xxn2	402	43	dependent	dependent	JJ
cord-261532-q923xxn2	402	44	kinase	kinase	NN
cord-261532-q923xxn2	402	45	of	of	IN
cord-261532-q923xxn2	402	46	MKK	MKK	NNP
cord-261532-q923xxn2	402	47	and	and	CC
cord-261532-q923xxn2	402	48	IKK	IKK	NNP
cord-261532-q923xxn2	402	49	Structure	Structure	NNP
cord-261532-q923xxn2	402	50	,	,	,
cord-261532-q923xxn2	402	51	function	function	NN
cord-261532-q923xxn2	402	52	and	and	CC
cord-261532-q923xxn2	402	53	regulation	regulation	NN
cord-261532-q923xxn2	402	54	of	of	IN
cord-261532-q923xxn2	402	55	the	the	DT
cord-261532-q923xxn2	402	56	Toll	Toll	NNP
cord-261532-q923xxn2	402	57	/	/	SYM
cord-261532-q923xxn2	402	58	IL-1	IL-1	NNP
cord-261532-q923xxn2	402	59	receptor	receptor	NN
cord-261532-q923xxn2	402	60	adaptor	adaptor	NN
cord-261532-q923xxn2	402	61	proteins	protein	NNS
cord-261532-q923xxn2	402	62	Critical	critical	JJ
cord-261532-q923xxn2	402	63	link	link	NN
cord-261532-q923xxn2	402	64	between	between	IN
cord-261532-q923xxn2	402	65	TRAIL	trail	NN
cord-261532-q923xxn2	402	66	and	and	CC
cord-261532-q923xxn2	402	67	CCL20	CCL20	VBZ
cord-261532-q923xxn2	402	68	for	for	IN
cord-261532-q923xxn2	402	69	the	the	DT
cord-261532-q923xxn2	402	70	activation	activation	NN
cord-261532-q923xxn2	402	71	of	of	IN
cord-261532-q923xxn2	402	72	TH2	TH2	NNP
cord-261532-q923xxn2	402	73	cells	cell	NNS
cord-261532-q923xxn2	402	74	and	and	CC
cord-261532-q923xxn2	402	75	the	the	DT
cord-261532-q923xxn2	402	76	expression	expression	NN
cord-261532-q923xxn2	402	77	of	of	IN
cord-261532-q923xxn2	402	78	allergic	allergic	JJ
cord-261532-q923xxn2	402	79	airway	airway	NN
cord-261532-q923xxn2	402	80	disease	disease	NN
cord-261532-q923xxn2	402	81	Organ	Organ	NNP
cord-261532-q923xxn2	402	82	-	-	HYPH
cord-261532-q923xxn2	402	83	secific	secific	NNP
cord-261532-q923xxn2	402	84	role	role	NN
cord-261532-q923xxn2	402	85	of	of	IN
cord-261532-q923xxn2	402	86	MyD88	MyD88	NNP
cord-261532-q923xxn2	402	87	for	for	IN
cord-261532-q923xxn2	402	88	gene	gene	NN
cord-261532-q923xxn2	402	89	regulation	regulation	NN
cord-261532-q923xxn2	402	90	during	during	IN
cord-261532-q923xxn2	402	91	polymicrobial	polymicrobial	JJ
cord-261532-q923xxn2	402	92	peritonitis	peritonitis	NN
cord-261532-q923xxn2	402	93	Lung	lung	NN
cord-261532-q923xxn2	402	94	-	-	HYPH
cord-261532-q923xxn2	402	95	specific	specific	JJ
cord-261532-q923xxn2	402	96	overexpression	overexpression	NN
cord-261532-q923xxn2	402	97	of	of	IN
cord-261532-q923xxn2	402	98	CC	cc	NN
cord-261532-q923xxn2	402	99	chemokine	chemokine	NN
cord-261532-q923xxn2	402	100	ligand	ligand	NN
cord-261532-q923xxn2	402	101	(	(	-LRB-
cord-261532-q923xxn2	402	102	CCL	CCL	NNP
cord-261532-q923xxn2	402	103	)	)	-RRB-
cord-261532-q923xxn2	402	104	2	2	CD
cord-261532-q923xxn2	402	105	enhances	enhance	VBZ
cord-261532-q923xxn2	402	106	the	the	DT
cord-261532-q923xxn2	402	107	host	host	NN
cord-261532-q923xxn2	402	108	defense	defense	NN
cord-261532-q923xxn2	402	109	to	to	IN
cord-261532-q923xxn2	402	110	Streptococcus	streptococcus	NN
cord-261532-q923xxn2	402	111	pneumoniae	pneumoniae	NN
cord-261532-q923xxn2	402	112	infection	infection	NN
cord-261532-q923xxn2	402	113	in	in	IN
cord-261532-q923xxn2	402	114	mice	mouse	NNS
cord-261532-q923xxn2	402	115	:	:	:
cord-261532-q923xxn2	402	116	role	role	NN
cord-261532-q923xxn2	402	117	of	of	IN
cord-261532-q923xxn2	402	118	the	the	DT
cord-261532-q923xxn2	402	119	CCL2-CCR2	CCL2-CCR2	NNP
cord-261532-q923xxn2	402	120	axis	axis	NN
cord-261532-q923xxn2	402	121	VISA	VISA	NNP
cord-261532-q923xxn2	402	122	is	be	VBZ
cord-261532-q923xxn2	402	123	an	an	DT
cord-261532-q923xxn2	402	124	adapter	adapter	NN
cord-261532-q923xxn2	402	125	protein	protein	NN
cord-261532-q923xxn2	402	126	required	require	VBN
cord-261532-q923xxn2	402	127	for	for	IN
cord-261532-q923xxn2	402	128	virus	virus	NN
cord-261532-q923xxn2	402	129	-	-	HYPH
cord-261532-q923xxn2	402	130	triggered	trigger	VBN
cord-261532-q923xxn2	402	131	IFN	IFN	NNP
cord-261532-q923xxn2	402	132	-	-	HYPH
cord-261532-q923xxn2	402	133	β	β	NNP
cord-261532-q923xxn2	402	134	signaling	signal	VBG
cord-261532-q923xxn2	402	135	Role	role	NN
cord-261532-q923xxn2	402	136	of	of	IN
cord-261532-q923xxn2	402	137	adaptor	adaptor	NN
cord-261532-q923xxn2	402	138	TRIF	TRIF	NNP
cord-261532-q923xxn2	402	139	in	in	IN
cord-261532-q923xxn2	402	140	the	the	DT
cord-261532-q923xxn2	402	141	MyD88-independent	MyD88-independent	NNP
cord-261532-q923xxn2	402	142	toll	toll	NN
cord-261532-q923xxn2	402	143	-	-	HYPH
cord-261532-q923xxn2	402	144	like	like	JJ
cord-261532-q923xxn2	402	145	receptor	receptor	NN
cord-261532-q923xxn2	402	146	signaling	signal	VBG
cord-261532-q923xxn2	402	147	pathway	pathway	NN
cord-261532-q923xxn2	403	1	The	the	DT
cord-261532-q923xxn2	403	2	cytosolic	cytosolic	JJ
cord-261532-q923xxn2	403	3	exonuclease	exonuclease	NN
cord-261532-q923xxn2	404	1	TREX1	TREX1	NNP
cord-261532-q923xxn2	404	2	inhibits	inhibit	VBZ
cord-261532-q923xxn2	404	3	the	the	DT
cord-261532-q923xxn2	404	4	innate	innate	JJ
cord-261532-q923xxn2	404	5	immune	immune	JJ
cord-261532-q923xxn2	404	6	response	response	NN
cord-261532-q923xxn2	404	7	to	to	IN
cord-261532-q923xxn2	404	8	human	human	JJ
cord-261532-q923xxn2	404	9	immunodeficiency	immunodeficiency	NN
cord-261532-q923xxn2	404	10	virus	virus	NN
cord-261532-q923xxn2	404	11	type	type	NN
cord-261532-q923xxn2	404	12	1	1	CD
cord-261532-q923xxn2	404	13	Structural	structural	JJ
cord-261532-q923xxn2	404	14	mechanism	mechanism	NN
cord-261532-q923xxn2	404	15	of	of	IN
cord-261532-q923xxn2	404	16	RNA	RNA	NNP
cord-261532-q923xxn2	404	17	recognition	recognition	NN
cord-261532-q923xxn2	404	18	by	by	IN
cord-261532-q923xxn2	404	19	the	the	DT
cord-261532-q923xxn2	404	20	RIG	rig	NN
cord-261532-q923xxn2	404	21	-	-	HYPH
cord-261532-q923xxn2	404	22	I	i	NN
cord-261532-q923xxn2	404	23	-	-	HYPH
cord-261532-q923xxn2	404	24	like	like	JJ
cord-261532-q923xxn2	404	25	receptors	receptor	NNS
cord-261532-q923xxn2	404	26	Reconstitution	Reconstitution	NNP
cord-261532-q923xxn2	404	27	of	of	IN
cord-261532-q923xxn2	404	28	the	the	DT
cord-261532-q923xxn2	404	29	RIG	rig	NN
cord-261532-q923xxn2	405	1	-I	-I	NNP
cord-261532-q923xxn2	405	2	pathway	pathway	NN
cord-261532-q923xxn2	405	3	reveals	reveal	VBZ
cord-261532-q923xxn2	405	4	a	a	DT
cord-261532-q923xxn2	405	5	signaling	signal	VBG
cord-261532-q923xxn2	405	6	role	role	NN
cord-261532-q923xxn2	405	7	of	of	IN
cord-261532-q923xxn2	405	8	unanchored	unanchored	JJ
cord-261532-q923xxn2	405	9	polyubiquitin	polyubiquitin	NNS
cord-261532-q923xxn2	405	10	chains	chain	NNS
cord-261532-q923xxn2	405	11	in	in	IN
cord-261532-q923xxn2	405	12	innate	innate	JJ
cord-261532-q923xxn2	405	13	immunity	immunity	NN
cord-261532-q923xxn2	406	1	The	the	DT
cord-261532-q923xxn2	406	2	NLRC4	nlrc4	NN
cord-261532-q923xxn2	407	1	inflammasome	inflammasome	NNP
cord-261532-q923xxn2	407	2	receptors	receptor	NNS
cord-261532-q923xxn2	407	3	for	for	IN
cord-261532-q923xxn2	407	4	bacterial	bacterial	JJ
cord-261532-q923xxn2	407	5	flagellin	flagellin	NN
cord-261532-q923xxn2	407	6	and	and	CC
cord-261532-q923xxn2	408	1	type	type	NN
cord-261532-q923xxn2	408	2	III	iii	CD
cord-261532-q923xxn2	408	3	secretion	secretion	NN
cord-261532-q923xxn2	408	4	apparatus	apparatus	NN
cord-261532-q923xxn2	409	1	The	the	DT
cord-261532-q923xxn2	409	2	adaptor	adaptor	NN
cord-261532-q923xxn2	409	3	protein	protein	NN
cord-261532-q923xxn2	409	4	MITA	MITA	NNP
cord-261532-q923xxn2	409	5	links	link	VBZ
cord-261532-q923xxn2	409	6	virus	virus	NN
cord-261532-q923xxn2	409	7	-	-	HYPH
cord-261532-q923xxn2	409	8	sensing	sense	VBG
cord-261532-q923xxn2	409	9	receptors	receptor	NNS
cord-261532-q923xxn2	409	10	to	to	IN
cord-261532-q923xxn2	409	11	IRF3	IRF3	NNP
cord-261532-q923xxn2	409	12	transcription	transcription	NN
cord-261532-q923xxn2	409	13	factor	factor	NN
cord-261532-q923xxn2	409	14	activation	activation	NN