id	sid	tid	token	lemma	pos
cord-301362-f3lp10lm	1	1	key	key	NN
cord-301362-f3lp10lm	1	2	:	:	:
cord-301362-f3lp10lm	1	3	cord-301362-f3lp10lm	cord-301362-f3lp10lm	NNS
cord-301362-f3lp10lm	1	4	authors	author	NNS
cord-301362-f3lp10lm	1	5	:	:	:
cord-301362-f3lp10lm	1	6	Delgui	Delgui	NNP
cord-301362-f3lp10lm	1	7	,	,	,
cord-301362-f3lp10lm	1	8	Laura	Laura	NNP
cord-301362-f3lp10lm	1	9	R.	R.	NNP
cord-301362-f3lp10lm	1	10	;	;	:
cord-301362-f3lp10lm	1	11	Colombo	Colombo	NNP
cord-301362-f3lp10lm	1	12	,	,	,
cord-301362-f3lp10lm	1	13	María	María	NNP
cord-301362-f3lp10lm	1	14	I.	I.	NNP
cord-301362-f3lp10lm	2	1	title	title	NN
cord-301362-f3lp10lm	2	2	:	:	:
cord-301362-f3lp10lm	3	1	A	a	DT
cord-301362-f3lp10lm	3	2	Novel	Novel	NNP
cord-301362-f3lp10lm	3	3	Mechanism	Mechanism	NNP
cord-301362-f3lp10lm	3	4	Underlying	underlie	VBG
cord-301362-f3lp10lm	3	5	the	the	DT
cord-301362-f3lp10lm	3	6	Innate	Innate	NNP
cord-301362-f3lp10lm	3	7	Immune	Immune	NNP
cord-301362-f3lp10lm	3	8	Response	Response	NNP
cord-301362-f3lp10lm	3	9	Induction	Induction	NNP
cord-301362-f3lp10lm	3	10	upon	upon	IN
cord-301362-f3lp10lm	3	11	Viral	Viral	NNP
cord-301362-f3lp10lm	3	12	-	-	HYPH
cord-301362-f3lp10lm	3	13	Dependent	dependent	JJ
cord-301362-f3lp10lm	3	14	Replication	replication	NN
cord-301362-f3lp10lm	3	15	of	of	IN
cord-301362-f3lp10lm	3	16	Host	Host	NNP
cord-301362-f3lp10lm	3	17	Cell	Cell	NNP
cord-301362-f3lp10lm	4	1	mRNA	mrna	NN
cord-301362-f3lp10lm	4	2	:	:	:
cord-301362-f3lp10lm	4	3	A	a	DT
cord-301362-f3lp10lm	4	4	Mistake	mistake	NN
cord-301362-f3lp10lm	4	5	of	of	IN
cord-301362-f3lp10lm	4	6	+	+	CD
cord-301362-f3lp10lm	5	1	sRNA	sRNA	VBG
cord-301362-f3lp10lm	5	2	Viruses	Viruses	NNPS
cord-301362-f3lp10lm	5	3	'	'	POS
cord-301362-f3lp10lm	5	4	Replicases	Replicases	NNP
cord-301362-f3lp10lm	5	5	date	date	NN
cord-301362-f3lp10lm	5	6	:	:	:
cord-301362-f3lp10lm	5	7	2017	2017	CD
cord-301362-f3lp10lm	5	8	-	-	HYPH
cord-301362-f3lp10lm	5	9	01	01	CD
cord-301362-f3lp10lm	5	10	-	-	HYPH
cord-301362-f3lp10lm	5	11	20	20	CD
cord-301362-f3lp10lm	5	12	journal	journal	NN
cord-301362-f3lp10lm	5	13	:	:	:
cord-301362-f3lp10lm	6	1	Front	front	JJ
cord-301362-f3lp10lm	6	2	Cell	cell	NN
cord-301362-f3lp10lm	6	3	Infect	infect	VB
cord-301362-f3lp10lm	6	4	Microbiol	Microbiol	NNP
cord-301362-f3lp10lm	6	5	DOI	doi	NN
cord-301362-f3lp10lm	6	6	:	:	:
cord-301362-f3lp10lm	7	1	10.3389/	10.3389/	CD
cord-301362-f3lp10lm	8	1	fcimb.2017.00005	fcimb.2017.00005	CD
cord-301362-f3lp10lm	9	1	sha	sha	NNP
cord-301362-f3lp10lm	9	2	:	:	:
cord-301362-f3lp10lm	9	3	dc320a349f137013cc728b319144588e3854cb20	dc320a349f137013cc728b319144588e3854cb20	NNS
cord-301362-f3lp10lm	9	4	doc_id	doc_id	CD
cord-301362-f3lp10lm	9	5	:	:	:
cord-301362-f3lp10lm	10	1	301362	301362	CD
cord-301362-f3lp10lm	10	2	cord_uid	cord_uid	NN
cord-301362-f3lp10lm	10	3	:	:	:
cord-301362-f3lp10lm	11	1	f3lp10lm	f3lp10lm	NNS
cord-301362-f3lp10lm	11	2	Viruses	virus	NNS
cord-301362-f3lp10lm	11	3	are	be	VBP
cord-301362-f3lp10lm	11	4	lifeless	lifeless	JJ
cord-301362-f3lp10lm	11	5	particles	particle	NNS
cord-301362-f3lp10lm	11	6	designed	design	VBN
cord-301362-f3lp10lm	11	7	for	for	IN
cord-301362-f3lp10lm	11	8	setting	set	VBG
cord-301362-f3lp10lm	11	9	virus	virus	NN
cord-301362-f3lp10lm	11	10	-	-	HYPH
cord-301362-f3lp10lm	11	11	host	host	NN
cord-301362-f3lp10lm	11	12	interactome	interactome	NNP
cord-301362-f3lp10lm	11	13	assuring	assure	VBG
cord-301362-f3lp10lm	11	14	a	a	DT
cord-301362-f3lp10lm	11	15	new	new	JJ
cord-301362-f3lp10lm	11	16	generation	generation	NN
cord-301362-f3lp10lm	11	17	of	of	IN
cord-301362-f3lp10lm	11	18	virions	virion	NNS
cord-301362-f3lp10lm	11	19	for	for	IN
cord-301362-f3lp10lm	11	20	dissemination	dissemination	NN
cord-301362-f3lp10lm	11	21	.	.	.
cord-301362-f3lp10lm	12	1	This	this	DT
cord-301362-f3lp10lm	12	2	interactome	interactome	NN
cord-301362-f3lp10lm	12	3	generates	generate	VBZ
cord-301362-f3lp10lm	12	4	a	a	DT
cord-301362-f3lp10lm	12	5	pressure	pressure	NN
cord-301362-f3lp10lm	12	6	on	on	IN
cord-301362-f3lp10lm	12	7	host	host	NN
cord-301362-f3lp10lm	12	8	organisms	organism	NNS
cord-301362-f3lp10lm	12	9	evolving	evolve	VBG
cord-301362-f3lp10lm	12	10	mechanisms	mechanism	NNS
cord-301362-f3lp10lm	12	11	to	to	TO
cord-301362-f3lp10lm	12	12	neutralize	neutralize	VB
cord-301362-f3lp10lm	12	13	viral	viral	JJ
cord-301362-f3lp10lm	12	14	infection	infection	NN
cord-301362-f3lp10lm	12	15	,	,	,
cord-301362-f3lp10lm	12	16	which	which	WDT
cord-301362-f3lp10lm	12	17	places	place	VBZ
cord-301362-f3lp10lm	12	18	the	the	DT
cord-301362-f3lp10lm	12	19	pressure	pressure	NN
cord-301362-f3lp10lm	12	20	back	back	RB
cord-301362-f3lp10lm	12	21	onto	onto	IN
cord-301362-f3lp10lm	12	22	virus	virus	NN
cord-301362-f3lp10lm	12	23	,	,	,
cord-301362-f3lp10lm	12	24	a	a	DT
cord-301362-f3lp10lm	12	25	process	process	NN
cord-301362-f3lp10lm	12	26	known	know	VBN
cord-301362-f3lp10lm	12	27	as	as	IN
cord-301362-f3lp10lm	12	28	virus	virus	NN
cord-301362-f3lp10lm	12	29	-	-	HYPH
cord-301362-f3lp10lm	12	30	host	host	NN
cord-301362-f3lp10lm	12	31	cell	cell	NN
cord-301362-f3lp10lm	12	32	co	co	NN
cord-301362-f3lp10lm	12	33	-	-	NN
cord-301362-f3lp10lm	12	34	evolution	evolution	NN
cord-301362-f3lp10lm	12	35	.	.	.
cord-301362-f3lp10lm	13	1	Positive	positive	JJ
cord-301362-f3lp10lm	13	2	-	-	HYPH
cord-301362-f3lp10lm	13	3	single	single	JJ
cord-301362-f3lp10lm	13	4	stranded	strand	VBN
cord-301362-f3lp10lm	13	5	RNA	RNA	NNP
cord-301362-f3lp10lm	13	6	(	(	-LRB-
cord-301362-f3lp10lm	13	7	+	+	CC
cord-301362-f3lp10lm	14	1	sRNA	srna	LS
cord-301362-f3lp10lm	14	2	)	)	-RRB-
cord-301362-f3lp10lm	14	3	viruses	virus	NNS
cord-301362-f3lp10lm	14	4	are	be	VBP
cord-301362-f3lp10lm	14	5	an	an	DT
cord-301362-f3lp10lm	14	6	important	important	JJ
cord-301362-f3lp10lm	14	7	group	group	NN
cord-301362-f3lp10lm	14	8	of	of	IN
cord-301362-f3lp10lm	14	9	viral	viral	JJ
cord-301362-f3lp10lm	14	10	agents	agent	NNS
cord-301362-f3lp10lm	14	11	illustrating	illustrate	VBG
cord-301362-f3lp10lm	14	12	this	this	DT
cord-301362-f3lp10lm	14	13	interesting	interesting	JJ
cord-301362-f3lp10lm	14	14	phenomenon	phenomenon	NN
cord-301362-f3lp10lm	14	15	.	.	.
cord-301362-f3lp10lm	15	1	During	during	IN
cord-301362-f3lp10lm	15	2	replication	replication	NN
cord-301362-f3lp10lm	15	3	,	,	,
cord-301362-f3lp10lm	15	4	their	-PRON-	PRP$
cord-301362-f3lp10lm	15	5	genomic	genomic	JJ
cord-301362-f3lp10lm	15	6	+	+	SYM
cord-301362-f3lp10lm	15	7	sRNA	srna	NN
cord-301362-f3lp10lm	15	8	is	be	VBZ
cord-301362-f3lp10lm	15	9	employed	employ	VBN
cord-301362-f3lp10lm	15	10	as	as	IN
cord-301362-f3lp10lm	15	11	template	template	NN
cord-301362-f3lp10lm	15	12	for	for	IN
cord-301362-f3lp10lm	15	13	translation	translation	NN
cord-301362-f3lp10lm	15	14	of	of	IN
cord-301362-f3lp10lm	15	15	viral	viral	JJ
cord-301362-f3lp10lm	15	16	proteins	protein	NNS
cord-301362-f3lp10lm	15	17	;	;	:
cord-301362-f3lp10lm	15	18	among	among	IN
cord-301362-f3lp10lm	15	19	them	-PRON-	PRP
cord-301362-f3lp10lm	15	20	the	the	DT
cord-301362-f3lp10lm	15	21	RNA	RNA	NNP
cord-301362-f3lp10lm	15	22	-	-	HYPH
cord-301362-f3lp10lm	15	23	dependent	dependent	JJ
cord-301362-f3lp10lm	15	24	RNA	RNA	NNP
cord-301362-f3lp10lm	15	25	polymerase	polymerase	NN
cord-301362-f3lp10lm	15	26	(	(	-LRB-
cord-301362-f3lp10lm	15	27	RdRp	RdRp	NNP
cord-301362-f3lp10lm	15	28	)	)	-RRB-
cord-301362-f3lp10lm	15	29	is	be	VBZ
cord-301362-f3lp10lm	15	30	responsible	responsible	JJ
cord-301362-f3lp10lm	15	31	of	of	IN
cord-301362-f3lp10lm	15	32	viral	viral	JJ
cord-301362-f3lp10lm	15	33	genome	genome	NN
cord-301362-f3lp10lm	15	34	replication	replication	NN
cord-301362-f3lp10lm	15	35	originating	originate	VBG
cord-301362-f3lp10lm	15	36	double	double	JJ
cord-301362-f3lp10lm	15	37	-	-	HYPH
cord-301362-f3lp10lm	15	38	strand	strand	NN
cord-301362-f3lp10lm	15	39	RNA	RNA	NNP
cord-301362-f3lp10lm	15	40	molecules	molecule	NNS
cord-301362-f3lp10lm	15	41	(	(	-LRB-
cord-301362-f3lp10lm	15	42	dsRNA	dsrna	NN
cord-301362-f3lp10lm	15	43	)	)	-RRB-
cord-301362-f3lp10lm	15	44	as	as	IN
cord-301362-f3lp10lm	15	45	intermediates	intermediate	NNS
cord-301362-f3lp10lm	15	46	,	,	,
cord-301362-f3lp10lm	15	47	which	which	WDT
cord-301362-f3lp10lm	15	48	accumulate	accumulate	VBP
cord-301362-f3lp10lm	15	49	representing	represent	VBG
cord-301362-f3lp10lm	15	50	a	a	DT
cord-301362-f3lp10lm	15	51	potent	potent	JJ
cord-301362-f3lp10lm	15	52	threat	threat	NN
cord-301362-f3lp10lm	15	53	for	for	IN
cord-301362-f3lp10lm	15	54	cellular	cellular	JJ
cord-301362-f3lp10lm	15	55	dsRNA	dsrna	NN
cord-301362-f3lp10lm	15	56	receptors	receptor	NNS
cord-301362-f3lp10lm	15	57	to	to	TO
cord-301362-f3lp10lm	15	58	initiate	initiate	VB
cord-301362-f3lp10lm	15	59	an	an	DT
cord-301362-f3lp10lm	15	60	antiviral	antiviral	JJ
cord-301362-f3lp10lm	15	61	response	response	NN
cord-301362-f3lp10lm	15	62	.	.	.
cord-301362-f3lp10lm	16	1	A	a	DT
cord-301362-f3lp10lm	16	2	common	common	JJ
cord-301362-f3lp10lm	16	3	feature	feature	NN
cord-301362-f3lp10lm	16	4	shared	share	VBN
cord-301362-f3lp10lm	16	5	by	by	IN
cord-301362-f3lp10lm	16	6	these	these	DT
cord-301362-f3lp10lm	16	7	viruses	virus	NNS
cord-301362-f3lp10lm	16	8	is	be	VBZ
cord-301362-f3lp10lm	16	9	their	-PRON-	PRP$
cord-301362-f3lp10lm	16	10	ability	ability	NN
cord-301362-f3lp10lm	16	11	to	to	TO
cord-301362-f3lp10lm	16	12	rearrange	rearrange	VB
cord-301362-f3lp10lm	16	13	cellular	cellular	JJ
cord-301362-f3lp10lm	16	14	membranes	membrane	NNS
cord-301362-f3lp10lm	16	15	to	to	TO
cord-301362-f3lp10lm	16	16	serve	serve	VB
cord-301362-f3lp10lm	16	17	as	as	IN
cord-301362-f3lp10lm	16	18	platforms	platform	NNS
cord-301362-f3lp10lm	16	19	for	for	IN
cord-301362-f3lp10lm	16	20	genome	genome	NN
cord-301362-f3lp10lm	16	21	replication	replication	NN
cord-301362-f3lp10lm	16	22	and	and	CC
cord-301362-f3lp10lm	16	23	assembly	assembly	NN
cord-301362-f3lp10lm	16	24	of	of	IN
cord-301362-f3lp10lm	16	25	new	new	JJ
cord-301362-f3lp10lm	16	26	virions	virion	NNS
cord-301362-f3lp10lm	16	27	,	,	,
cord-301362-f3lp10lm	16	28	supporting	support	VBG
cord-301362-f3lp10lm	16	29	replication	replication	NN
cord-301362-f3lp10lm	16	30	efficiency	efficiency	NN
cord-301362-f3lp10lm	16	31	increase	increase	NN
cord-301362-f3lp10lm	16	32	by	by	IN
cord-301362-f3lp10lm	16	33	concentrating	concentrate	VBG
cord-301362-f3lp10lm	16	34	critical	critical	JJ
cord-301362-f3lp10lm	16	35	factors	factor	NNS
cord-301362-f3lp10lm	16	36	and	and	CC
cord-301362-f3lp10lm	16	37	protecting	protect	VBG
cord-301362-f3lp10lm	16	38	the	the	DT
cord-301362-f3lp10lm	16	39	viral	viral	JJ
cord-301362-f3lp10lm	16	40	genome	genome	NN
cord-301362-f3lp10lm	16	41	from	from	IN
cord-301362-f3lp10lm	16	42	host	host	JJ
cord-301362-f3lp10lm	16	43	anti	anti	JJ
cord-301362-f3lp10lm	16	44	-	-	JJ
cord-301362-f3lp10lm	16	45	viral	viral	JJ
cord-301362-f3lp10lm	16	46	systems	system	NNS
cord-301362-f3lp10lm	16	47	.	.	.
cord-301362-f3lp10lm	17	1	This	this	DT
cord-301362-f3lp10lm	17	2	review	review	NN
cord-301362-f3lp10lm	17	3	summarizes	summarize	VBZ
cord-301362-f3lp10lm	17	4	current	current	JJ
cord-301362-f3lp10lm	17	5	knowledge	knowledge	NN
cord-301362-f3lp10lm	17	6	regarding	regard	VBG
cord-301362-f3lp10lm	17	7	cellular	cellular	JJ
cord-301362-f3lp10lm	17	8	dsRNA	dsrna	NN
cord-301362-f3lp10lm	17	9	receptors	receptor	NNS
cord-301362-f3lp10lm	17	10	and	and	CC
cord-301362-f3lp10lm	17	11	describes	describe	VBZ
cord-301362-f3lp10lm	17	12	prototype	prototype	NN
cord-301362-f3lp10lm	17	13	viruses	virus	NNS
cord-301362-f3lp10lm	17	14	developing	develop	VBG
cord-301362-f3lp10lm	17	15	replication	replication	NN
cord-301362-f3lp10lm	17	16	niches	niche	NNS
cord-301362-f3lp10lm	17	17	inside	inside	IN
cord-301362-f3lp10lm	17	18	rearranged	rearrange	VBN
cord-301362-f3lp10lm	17	19	membranes	membrane	NNS
cord-301362-f3lp10lm	17	20	.	.	.
cord-301362-f3lp10lm	18	1	However	however	RB
cord-301362-f3lp10lm	18	2	,	,	,
cord-301362-f3lp10lm	18	3	for	for	IN
cord-301362-f3lp10lm	18	4	several	several	JJ
cord-301362-f3lp10lm	18	5	viral	viral	JJ
cord-301362-f3lp10lm	18	6	agents	agent	NNS
cord-301362-f3lp10lm	18	7	it	-PRON-	PRP
cord-301362-f3lp10lm	18	8	's	be	VBZ
cord-301362-f3lp10lm	18	9	been	be	VBN
cord-301362-f3lp10lm	18	10	observed	observe	VBN
cord-301362-f3lp10lm	18	11	both	both	DT
cord-301362-f3lp10lm	18	12	,	,	,
cord-301362-f3lp10lm	18	13	a	a	DT
cord-301362-f3lp10lm	18	14	complex	complex	JJ
cord-301362-f3lp10lm	18	15	rearrangement	rearrangement	NN
cord-301362-f3lp10lm	18	16	of	of	IN
cord-301362-f3lp10lm	18	17	cellular	cellular	JJ
cord-301362-f3lp10lm	18	18	membranes	membrane	NNS
cord-301362-f3lp10lm	18	19	and	and	CC
cord-301362-f3lp10lm	18	20	a	a	DT
cord-301362-f3lp10lm	18	21	strong	strong	JJ
cord-301362-f3lp10lm	18	22	innate	innate	JJ
cord-301362-f3lp10lm	18	23	immune	immune	JJ
cord-301362-f3lp10lm	18	24	antiviral	antiviral	JJ
cord-301362-f3lp10lm	18	25	response	response	NN
cord-301362-f3lp10lm	18	26	induction	induction	NN
cord-301362-f3lp10lm	18	27	.	.	.
cord-301362-f3lp10lm	19	1	So	so	RB
cord-301362-f3lp10lm	19	2	,	,	,
cord-301362-f3lp10lm	19	3	we	-PRON-	PRP
cord-301362-f3lp10lm	19	4	have	have	VBP
cord-301362-f3lp10lm	19	5	included	include	VBN
cord-301362-f3lp10lm	19	6	recent	recent	JJ
cord-301362-f3lp10lm	19	7	data	datum	NNS
cord-301362-f3lp10lm	19	8	explaining	explain	VBG
cord-301362-f3lp10lm	19	9	the	the	DT
cord-301362-f3lp10lm	19	10	mechanism	mechanism	NN
cord-301362-f3lp10lm	19	11	by	by	IN
cord-301362-f3lp10lm	19	12	,	,	,
cord-301362-f3lp10lm	19	13	even	even	RB
cord-301362-f3lp10lm	19	14	though	though	IN
cord-301362-f3lp10lm	19	15	viruses	virus	NNS
cord-301362-f3lp10lm	19	16	have	have	VBP
cord-301362-f3lp10lm	19	17	evolved	evolve	VBN
cord-301362-f3lp10lm	19	18	elegant	elegant	JJ
cord-301362-f3lp10lm	19	19	hideouts	hideout	NNS
cord-301362-f3lp10lm	19	20	,	,	,
cord-301362-f3lp10lm	19	21	host	host	NN
cord-301362-f3lp10lm	19	22	cells	cell	NNS
cord-301362-f3lp10lm	19	23	are	be	VBP
cord-301362-f3lp10lm	19	24	still	still	RB
cord-301362-f3lp10lm	19	25	able	able	JJ
cord-301362-f3lp10lm	19	26	to	to	TO
cord-301362-f3lp10lm	19	27	develop	develop	VB
cord-301362-f3lp10lm	19	28	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	19	29	receptors	receptor	NNS
cord-301362-f3lp10lm	19	30	-	-	HYPH
cord-301362-f3lp10lm	19	31	dependent	dependent	JJ
cord-301362-f3lp10lm	19	32	antiviral	antiviral	JJ
cord-301362-f3lp10lm	19	33	response	response	NN
cord-301362-f3lp10lm	19	34	.	.	.
cord-301362-f3lp10lm	20	1	A	a	DT
cord-301362-f3lp10lm	20	2	Novel	Novel	NNP
cord-301362-f3lp10lm	20	3	Mechanism	Mechanism	NNP
cord-301362-f3lp10lm	20	4	Underlying	underlie	VBG
cord-301362-f3lp10lm	20	5	the	the	DT
cord-301362-f3lp10lm	20	6	Innate	Innate	NNP
cord-301362-f3lp10lm	20	7	Immune	Immune	NNP
cord-301362-f3lp10lm	20	8	Response	Response	NNP
cord-301362-f3lp10lm	20	9	Induction	Induction	NNP
cord-301362-f3lp10lm	20	10	upon	upon	IN
cord-301362-f3lp10lm	20	11	Viral	Viral	NNP
cord-301362-f3lp10lm	20	12	-	-	HYPH
cord-301362-f3lp10lm	20	13	Dependent	dependent	JJ
cord-301362-f3lp10lm	20	14	Replication	replication	NN
cord-301362-f3lp10lm	20	15	of	of	IN
cord-301362-f3lp10lm	20	16	Host	Host	NNP
cord-301362-f3lp10lm	20	17	Cell	Cell	NNP
cord-301362-f3lp10lm	21	1	mRNA	mrna	NN
cord-301362-f3lp10lm	21	2	:	:	:
cord-301362-f3lp10lm	21	3	A	a	DT
cord-301362-f3lp10lm	21	4	Mistake	mistake	NN
cord-301362-f3lp10lm	21	5	of	of	IN
cord-301362-f3lp10lm	21	6	+	+	CD
cord-301362-f3lp10lm	22	1	sRNA	sRNA	VBG
cord-301362-f3lp10lm	22	2	Viruses	Viruses	NNPS
cord-301362-f3lp10lm	22	3	'	'	POS
cord-301362-f3lp10lm	22	4	Replicases	Replicases	NNP
cord-301362-f3lp10lm	22	5	INTRODUCTION	introduction	NN
cord-301362-f3lp10lm	22	6	Eukaryotic	eukaryotic	JJ
cord-301362-f3lp10lm	22	7	cells	cell	NNS
cord-301362-f3lp10lm	22	8	are	be	VBP
cord-301362-f3lp10lm	22	9	able	able	JJ
cord-301362-f3lp10lm	22	10	to	to	TO
cord-301362-f3lp10lm	22	11	detect	detect	VB
cord-301362-f3lp10lm	22	12	viruses	virus	NNS
cord-301362-f3lp10lm	22	13	at	at	IN
cord-301362-f3lp10lm	22	14	multiple	multiple	JJ
cord-301362-f3lp10lm	22	15	steps	step	NNS
cord-301362-f3lp10lm	22	16	and	and	CC
cord-301362-f3lp10lm	22	17	benefit	benefit	VB
cord-301362-f3lp10lm	22	18	from	from	IN
cord-301362-f3lp10lm	22	19	redundant	redundant	JJ
cord-301362-f3lp10lm	22	20	mechanisms	mechanism	NNS
cord-301362-f3lp10lm	22	21	with	with	IN
cord-301362-f3lp10lm	22	22	the	the	DT
cord-301362-f3lp10lm	22	23	aim	aim	NN
cord-301362-f3lp10lm	22	24	of	of	IN
cord-301362-f3lp10lm	22	25	limiting	limit	VBG
cord-301362-f3lp10lm	22	26	viral	viral	JJ
cord-301362-f3lp10lm	22	27	infections	infection	NNS
cord-301362-f3lp10lm	22	28	.	.	.
cord-301362-f3lp10lm	23	1	Recognition	recognition	NN
cord-301362-f3lp10lm	23	2	of	of	IN
cord-301362-f3lp10lm	23	3	viral	viral	JJ
cord-301362-f3lp10lm	23	4	double	double	JJ
cord-301362-f3lp10lm	23	5	-	-	HYPH
cord-301362-f3lp10lm	23	6	strand	strand	NN
cord-301362-f3lp10lm	23	7	RNA	RNA	NNP
cord-301362-f3lp10lm	23	8	(	(	-LRB-
cord-301362-f3lp10lm	23	9	dsRNA	dsrna	NN
cord-301362-f3lp10lm	23	10	)	)	-RRB-
cord-301362-f3lp10lm	23	11	molecules	molecule	NNS
cord-301362-f3lp10lm	23	12	by	by	IN
cord-301362-f3lp10lm	23	13	intracellular	intracellular	JJ
cord-301362-f3lp10lm	23	14	Toll	toll	NN
cord-301362-f3lp10lm	23	15	-	-	HYPH
cord-301362-f3lp10lm	23	16	like	like	JJ
cord-301362-f3lp10lm	23	17	receptors	receptor	NNS
cord-301362-f3lp10lm	23	18	(	(	-LRB-
cord-301362-f3lp10lm	23	19	TLRs	TLRs	NNP
cord-301362-f3lp10lm	23	20	)	)	-RRB-
cord-301362-f3lp10lm	23	21	or	or	CC
cord-301362-f3lp10lm	23	22	retinoic	retinoic	JJ
cord-301362-f3lp10lm	23	23	acid	acid	NN
cord-301362-f3lp10lm	23	24	inducible	inducible	JJ
cord-301362-f3lp10lm	23	25	gene	gene	NN
cord-301362-f3lp10lm	23	26	I	I	NNP
cord-301362-f3lp10lm	23	27	-	-	HYPH
cord-301362-f3lp10lm	23	28	like	like	JJ
cord-301362-f3lp10lm	23	29	receptors	receptor	NNS
cord-301362-f3lp10lm	23	30	(	(	-LRB-
cord-301362-f3lp10lm	23	31	RLRs	RLRs	NNP
cord-301362-f3lp10lm	23	32	)	)	-RRB-
cord-301362-f3lp10lm	23	33	is	be	VBZ
cord-301362-f3lp10lm	23	34	a	a	DT
cord-301362-f3lp10lm	23	35	central	central	JJ
cord-301362-f3lp10lm	23	36	event	event	NN
cord-301362-f3lp10lm	23	37	which	which	WDT
cord-301362-f3lp10lm	23	38	entails	entail	VBZ
cord-301362-f3lp10lm	23	39	the	the	DT
cord-301362-f3lp10lm	23	40	early	early	JJ
cord-301362-f3lp10lm	23	41	steps	step	NNS
cord-301362-f3lp10lm	23	42	of	of	IN
cord-301362-f3lp10lm	23	43	the	the	DT
cord-301362-f3lp10lm	23	44	immune	immune	JJ
cord-301362-f3lp10lm	23	45	response	response	NN
cord-301362-f3lp10lm	23	46	elicited	elicit	VBN
cord-301362-f3lp10lm	23	47	during	during	IN
cord-301362-f3lp10lm	23	48	viral	viral	JJ
cord-301362-f3lp10lm	23	49	infections	infection	NNS
cord-301362-f3lp10lm	23	50	.	.	.
cord-301362-f3lp10lm	24	1	A	a	DT
cord-301362-f3lp10lm	24	2	functional	functional	JJ
cord-301362-f3lp10lm	24	3	anti	anti	JJ
cord-301362-f3lp10lm	24	4	-	-	JJ
cord-301362-f3lp10lm	24	5	viral	viral	JJ
cord-301362-f3lp10lm	24	6	role	role	NN
cord-301362-f3lp10lm	24	7	of	of	IN
cord-301362-f3lp10lm	24	8	TLR3	TLR3	NNP
cord-301362-f3lp10lm	24	9	has	have	VBZ
cord-301362-f3lp10lm	24	10	been	be	VBN
cord-301362-f3lp10lm	24	11	demonstrated	demonstrate	VBN
cord-301362-f3lp10lm	24	12	for	for	IN
cord-301362-f3lp10lm	24	13	several	several	JJ
cord-301362-f3lp10lm	24	14	animal	animal	NN
cord-301362-f3lp10lm	24	15	and	and	CC
cord-301362-f3lp10lm	24	16	human	human	JJ
cord-301362-f3lp10lm	24	17	viruses	virus	NNS
cord-301362-f3lp10lm	24	18	,	,	,
cord-301362-f3lp10lm	24	19	recently	recently	RB
cord-301362-f3lp10lm	24	20	reviewed	review	VBN
cord-301362-f3lp10lm	24	21	in	in	IN
cord-301362-f3lp10lm	24	22	Matsumoto	Matsumoto	NNP
cord-301362-f3lp10lm	24	23	et	et	NNP
cord-301362-f3lp10lm	24	24	al	al	NNP
cord-301362-f3lp10lm	24	25	.	.	.
cord-301362-f3lp10lm	25	1	(	(	-LRB-
cord-301362-f3lp10lm	25	2	2011	2011	CD
cord-301362-f3lp10lm	25	3	)	)	-RRB-
cord-301362-f3lp10lm	25	4	.	.	.
cord-301362-f3lp10lm	26	1	The	the	DT
cord-301362-f3lp10lm	26	2	RLRs	rlr	NNS
cord-301362-f3lp10lm	26	3	family	family	NN
cord-301362-f3lp10lm	26	4	,	,	,
cord-301362-f3lp10lm	26	5	including	include	VBG
cord-301362-f3lp10lm	26	6	the	the	DT
cord-301362-f3lp10lm	26	7	retinoic	retinoic	JJ
cord-301362-f3lp10lm	26	8	acid	acid	NN
cord-301362-f3lp10lm	26	9	inducible	inducible	JJ
cord-301362-f3lp10lm	26	10	gene	gene	NN
cord-301362-f3lp10lm	27	1	I	-PRON-	PRP
cord-301362-f3lp10lm	27	2	(	(	-LRB-
cord-301362-f3lp10lm	27	3	RIG	rig	NN
cord-301362-f3lp10lm	27	4	-	-	:
cord-301362-f3lp10lm	27	5	I	I	NNP
cord-301362-f3lp10lm	27	6	)	)	-RRB-
cord-301362-f3lp10lm	27	7	,	,	,
cord-301362-f3lp10lm	27	8	the	the	DT
cord-301362-f3lp10lm	27	9	melanoma	melanoma	NN
cord-301362-f3lp10lm	27	10	differentiation	differentiation	NN
cord-301362-f3lp10lm	27	11	-	-	HYPH
cord-301362-f3lp10lm	27	12	associated	associate	VBN
cord-301362-f3lp10lm	27	13	gene	gene	NN
cord-301362-f3lp10lm	27	14	5	5	CD
cord-301362-f3lp10lm	27	15	(	(	-LRB-
cord-301362-f3lp10lm	27	16	MDA5	MDA5	NNP
cord-301362-f3lp10lm	27	17	)	)	-RRB-
cord-301362-f3lp10lm	27	18	and	and	CC
cord-301362-f3lp10lm	27	19	laboratory	laboratory	NN
cord-301362-f3lp10lm	27	20	of	of	IN
cord-301362-f3lp10lm	27	21	genetics	genetic	NNS
cord-301362-f3lp10lm	27	22	and	and	CC
cord-301362-f3lp10lm	27	23	physiology	physiology	NN
cord-301362-f3lp10lm	27	24	2	2	CD
cord-301362-f3lp10lm	27	25	(	(	-LRB-
cord-301362-f3lp10lm	27	26	LGP2	LGP2	NNP
cord-301362-f3lp10lm	27	27	)	)	-RRB-
cord-301362-f3lp10lm	27	28	,	,	,
cord-301362-f3lp10lm	27	29	represent	represent	VBP
cord-301362-f3lp10lm	27	30	another	another	DT
cord-301362-f3lp10lm	27	31	powerful	powerful	JJ
cord-301362-f3lp10lm	27	32	anti	anti	JJ
cord-301362-f3lp10lm	27	33	-	-	JJ
cord-301362-f3lp10lm	27	34	viral	viral	JJ
cord-301362-f3lp10lm	27	35	tool	tool	NN
cord-301362-f3lp10lm	27	36	parallel	parallel	JJ
cord-301362-f3lp10lm	27	37	to	to	IN
cord-301362-f3lp10lm	27	38	that	that	DT
cord-301362-f3lp10lm	27	39	comprised	comprise	VBN
cord-301362-f3lp10lm	27	40	by	by	IN
cord-301362-f3lp10lm	27	41	TLR3	TLR3	NNP
cord-301362-f3lp10lm	27	42	.	.	.
cord-301362-f3lp10lm	28	1	RIG	rig	NN
cord-301362-f3lp10lm	28	2	-	-	:
cord-301362-f3lp10lm	28	3	I	I	NNP
cord-301362-f3lp10lm	28	4	,	,	,
cord-301362-f3lp10lm	28	5	the	the	DT
cord-301362-f3lp10lm	28	6	leading	lead	VBG
cord-301362-f3lp10lm	28	7	member	member	NN
cord-301362-f3lp10lm	28	8	of	of	IN
cord-301362-f3lp10lm	28	9	the	the	DT
cord-301362-f3lp10lm	28	10	RLRs	rlr	NNS
cord-301362-f3lp10lm	28	11	,	,	,
cord-301362-f3lp10lm	28	12	is	be	VBZ
cord-301362-f3lp10lm	28	13	activated	activate	VBN
cord-301362-f3lp10lm	28	14	upon	upon	IN
cord-301362-f3lp10lm	28	15	dsRNA	dsrna	NN
cord-301362-f3lp10lm	28	16	recognition	recognition	NN
cord-301362-f3lp10lm	28	17	generating	generate	VBG
cord-301362-f3lp10lm	28	18	the	the	DT
cord-301362-f3lp10lm	28	19	production	production	NN
cord-301362-f3lp10lm	28	20	of	of	IN
cord-301362-f3lp10lm	28	21	an	an	DT
cord-301362-f3lp10lm	28	22	anti	anti	JJ
cord-301362-f3lp10lm	28	23	-	-	JJ
cord-301362-f3lp10lm	28	24	viral	viral	JJ
cord-301362-f3lp10lm	28	25	state	state	NN
cord-301362-f3lp10lm	28	26	in	in	IN
cord-301362-f3lp10lm	28	27	the	the	DT
cord-301362-f3lp10lm	28	28	infected	infect	VBN
cord-301362-f3lp10lm	28	29	-	-	HYPH
cord-301362-f3lp10lm	28	30	cell	cell	NN
cord-301362-f3lp10lm	28	31	and	and	CC
cord-301362-f3lp10lm	28	32	in	in	IN
cord-301362-f3lp10lm	28	33	the	the	DT
cord-301362-f3lp10lm	28	34	surrounding	surround	VBG
cord-301362-f3lp10lm	28	35	tissue	tissue	NN
cord-301362-f3lp10lm	28	36	.	.	.
cord-301362-f3lp10lm	29	1	Its	-PRON-	PRP$
cord-301362-f3lp10lm	29	2	specific	specific	JJ
cord-301362-f3lp10lm	29	3	activity	activity	NN
cord-301362-f3lp10lm	29	4	has	have	VBZ
cord-301362-f3lp10lm	29	5	been	be	VBN
cord-301362-f3lp10lm	29	6	extended	extend	VBN
cord-301362-f3lp10lm	29	7	reviewed	review	VBN
cord-301362-f3lp10lm	29	8	by	by	IN
cord-301362-f3lp10lm	29	9	Kell	Kell	NNP
cord-301362-f3lp10lm	29	10	and	and	CC
cord-301362-f3lp10lm	29	11	Gale	Gale	NNP
cord-301362-f3lp10lm	29	12	(	(	-LRB-
cord-301362-f3lp10lm	29	13	2015	2015	CD
cord-301362-f3lp10lm	29	14	)	)	-RRB-
cord-301362-f3lp10lm	29	15	.	.	.
cord-301362-f3lp10lm	30	1	Since	since	IN
cord-301362-f3lp10lm	30	2	we	-PRON-	PRP
cord-301362-f3lp10lm	30	3	consider	consider	VBP
cord-301362-f3lp10lm	30	4	TLR3	TLR3	NNP
cord-301362-f3lp10lm	30	5	,	,	,
cord-301362-f3lp10lm	30	6	RIG	rig	NN
cord-301362-f3lp10lm	30	7	-	-	:
cord-301362-f3lp10lm	30	8	I	I	NNP
cord-301362-f3lp10lm	30	9	,	,	,
cord-301362-f3lp10lm	30	10	and	and	CC
cord-301362-f3lp10lm	30	11	MDA-5	MDA-5	NNP
cord-301362-f3lp10lm	30	12	as	as	IN
cord-301362-f3lp10lm	30	13	"	"	``
cord-301362-f3lp10lm	30	14	major	major	JJ
cord-301362-f3lp10lm	30	15	sentries	sentry	NNS
cord-301362-f3lp10lm	30	16	"	"	''
cord-301362-f3lp10lm	30	17	of	of	IN
cord-301362-f3lp10lm	30	18	viral	viral	JJ
cord-301362-f3lp10lm	30	19	dsRNA	dsrna	NN
cord-301362-f3lp10lm	30	20	molecules	molecule	NNS
cord-301362-f3lp10lm	30	21	,	,	,
cord-301362-f3lp10lm	30	22	a	a	DT
cord-301362-f3lp10lm	30	23	brief	brief	JJ
cord-301362-f3lp10lm	30	24	revision	revision	NN
cord-301362-f3lp10lm	30	25	of	of	IN
cord-301362-f3lp10lm	30	26	their	-PRON-	PRP$
cord-301362-f3lp10lm	30	27	specific	specific	JJ
cord-301362-f3lp10lm	30	28	anti	anti	JJ
cord-301362-f3lp10lm	30	29	-	-	JJ
cord-301362-f3lp10lm	30	30	viral	viral	JJ
cord-301362-f3lp10lm	30	31	action	action	NN
cord-301362-f3lp10lm	30	32	will	will	MD
cord-301362-f3lp10lm	30	33	be	be	VB
cord-301362-f3lp10lm	30	34	presented	present	VBN
cord-301362-f3lp10lm	30	35	in	in	IN
cord-301362-f3lp10lm	30	36	this	this	DT
cord-301362-f3lp10lm	30	37	report	report	NN
cord-301362-f3lp10lm	30	38	.	.	.
cord-301362-f3lp10lm	31	1	As	as	IN
cord-301362-f3lp10lm	31	2	forced	force	VBN
cord-301362-f3lp10lm	31	3	intracellular	intracellular	JJ
cord-301362-f3lp10lm	31	4	parasites	parasite	NNS
cord-301362-f3lp10lm	31	5	,	,	,
cord-301362-f3lp10lm	31	6	viral	viral	JJ
cord-301362-f3lp10lm	31	7	agents	agent	NNS
cord-301362-f3lp10lm	31	8	relay	relay	VBP
cord-301362-f3lp10lm	31	9	on	on	IN
cord-301362-f3lp10lm	31	10	the	the	DT
cord-301362-f3lp10lm	31	11	host	host	NN
cord-301362-f3lp10lm	31	12	cell	cell	NN
cord-301362-f3lp10lm	31	13	biosynthetic	biosynthetic	JJ
cord-301362-f3lp10lm	31	14	pathway	pathway	NN
cord-301362-f3lp10lm	31	15	in	in	IN
cord-301362-f3lp10lm	31	16	order	order	NN
cord-301362-f3lp10lm	31	17	to	to	TO
cord-301362-f3lp10lm	31	18	follow	follow	VB
cord-301362-f3lp10lm	31	19	their	-PRON-	PRP$
cord-301362-f3lp10lm	31	20	replication	replication	NN
cord-301362-f3lp10lm	31	21	program	program	NN
cord-301362-f3lp10lm	31	22	to	to	TO
cord-301362-f3lp10lm	31	23	generate	generate	VB
cord-301362-f3lp10lm	31	24	new	new	JJ
cord-301362-f3lp10lm	31	25	viral	viral	JJ
cord-301362-f3lp10lm	31	26	progeny	progeny	NN
cord-301362-f3lp10lm	31	27	.	.	.
cord-301362-f3lp10lm	32	1	Since	since	IN
cord-301362-f3lp10lm	32	2	+	+	``
cord-301362-f3lp10lm	32	3	sRNA	srna	NN
cord-301362-f3lp10lm	32	4	viruses	virus	NNS
cord-301362-f3lp10lm	32	5	generate	generate	VBP
cord-301362-f3lp10lm	32	6	dsRNA	dsrna	NN
cord-301362-f3lp10lm	32	7	molecules	molecule	NNS
cord-301362-f3lp10lm	32	8	during	during	IN
cord-301362-f3lp10lm	32	9	their	-PRON-	PRP$
cord-301362-f3lp10lm	32	10	replication	replication	NN
cord-301362-f3lp10lm	32	11	process	process	NN
cord-301362-f3lp10lm	32	12	,	,	,
cord-301362-f3lp10lm	32	13	they	-PRON-	PRP
cord-301362-f3lp10lm	32	14	have	have	VBP
cord-301362-f3lp10lm	32	15	the	the	DT
cord-301362-f3lp10lm	32	16	necessity	necessity	NN
cord-301362-f3lp10lm	32	17	of	of	IN
cord-301362-f3lp10lm	32	18	hiding	hide	VBG
cord-301362-f3lp10lm	32	19	their	-PRON-	PRP$
cord-301362-f3lp10lm	32	20	genome	genome	NN
cord-301362-f3lp10lm	32	21	from	from	IN
cord-301362-f3lp10lm	32	22	the	the	DT
cord-301362-f3lp10lm	32	23	host	host	NN
cord-301362-f3lp10lm	32	24	cellular	cellular	JJ
cord-301362-f3lp10lm	32	25	dsRNA	dsrna	NN
cord-301362-f3lp10lm	32	26	sentries	sentry	NNS
cord-301362-f3lp10lm	32	27	.	.	.
cord-301362-f3lp10lm	33	1	So	so	RB
cord-301362-f3lp10lm	33	2	,	,	,
cord-301362-f3lp10lm	33	3	the	the	DT
cord-301362-f3lp10lm	33	4	induction	induction	NN
cord-301362-f3lp10lm	33	5	of	of	IN
cord-301362-f3lp10lm	33	6	specialized	specialized	JJ
cord-301362-f3lp10lm	33	7	membranous	membranous	JJ
cord-301362-f3lp10lm	33	8	niches	niche	NNS
cord-301362-f3lp10lm	33	9	,	,	,
cord-301362-f3lp10lm	33	10	often	often	RB
cord-301362-f3lp10lm	33	11	forming	form	VBG
cord-301362-f3lp10lm	33	12	organelle	organelle	NN
cord-301362-f3lp10lm	33	13	-	-	HYPH
cord-301362-f3lp10lm	33	14	like	like	JJ
cord-301362-f3lp10lm	33	15	structures	structure	NNS
cord-301362-f3lp10lm	33	16	,	,	,
cord-301362-f3lp10lm	33	17	is	be	VBZ
cord-301362-f3lp10lm	33	18	a	a	DT
cord-301362-f3lp10lm	33	19	common	common	JJ
cord-301362-f3lp10lm	33	20	feature	feature	NN
cord-301362-f3lp10lm	33	21	among	among	IN
cord-301362-f3lp10lm	33	22	these	these	DT
cord-301362-f3lp10lm	33	23	viruses	virus	NNS
cord-301362-f3lp10lm	33	24	.	.	.
cord-301362-f3lp10lm	34	1	With	with	IN
cord-301362-f3lp10lm	34	2	the	the	DT
cord-301362-f3lp10lm	34	3	aide	aide	NN
cord-301362-f3lp10lm	34	4	of	of	IN
cord-301362-f3lp10lm	34	5	pioneering	pioneer	VBG
cord-301362-f3lp10lm	34	6	classical	classical	JJ
cord-301362-f3lp10lm	34	7	electron	electron	NN
cord-301362-f3lp10lm	34	8	microscopy	microscopy	NN
cord-301362-f3lp10lm	34	9	(	(	-LRB-
cord-301362-f3lp10lm	34	10	EM	EM	NNP
cord-301362-f3lp10lm	34	11	)	)	-RRB-
cord-301362-f3lp10lm	34	12	and	and	CC
cord-301362-f3lp10lm	34	13	,	,	,
cord-301362-f3lp10lm	34	14	during	during	IN
cord-301362-f3lp10lm	34	15	the	the	DT
cord-301362-f3lp10lm	34	16	past	past	JJ
cord-301362-f3lp10lm	34	17	few	few	JJ
cord-301362-f3lp10lm	34	18	years	year	NNS
cord-301362-f3lp10lm	34	19	the	the	DT
cord-301362-f3lp10lm	34	20	most	most	RBS
cord-301362-f3lp10lm	34	21	sophisticated	sophisticated	JJ
cord-301362-f3lp10lm	34	22	electron	electron	NN
cord-301362-f3lp10lm	34	23	tomography	tomography	NN
cord-301362-f3lp10lm	34	24	,	,	,
cord-301362-f3lp10lm	34	25	several	several	JJ
cord-301362-f3lp10lm	34	26	3-D	3-d	JJ
cord-301362-f3lp10lm	34	27	architecture	architecture	NN
cord-301362-f3lp10lm	34	28	of	of	IN
cord-301362-f3lp10lm	34	29	viral	viral	JJ
cord-301362-f3lp10lm	34	30	replication	replication	NN
cord-301362-f3lp10lm	34	31	factories	factory	NNS
cord-301362-f3lp10lm	34	32	have	have	VBP
cord-301362-f3lp10lm	34	33	been	be	VBN
cord-301362-f3lp10lm	34	34	deciphered	decipher	VBN
cord-301362-f3lp10lm	34	35	(	(	-LRB-
cord-301362-f3lp10lm	34	36	for	for	IN
cord-301362-f3lp10lm	34	37	a	a	DT
cord-301362-f3lp10lm	34	38	technical	technical	JJ
cord-301362-f3lp10lm	34	39	review	review	NN
cord-301362-f3lp10lm	34	40	on	on	IN
cord-301362-f3lp10lm	34	41	electron	electron	NN
cord-301362-f3lp10lm	34	42	tomography	tomography	NN
cord-301362-f3lp10lm	34	43	,	,	,
cord-301362-f3lp10lm	34	44	see	see	VB
cord-301362-f3lp10lm	34	45	Frey	Frey	NNP
cord-301362-f3lp10lm	34	46	et	et	NNP
cord-301362-f3lp10lm	34	47	al	al	NNP
cord-301362-f3lp10lm	34	48	.	.	NNP
cord-301362-f3lp10lm	34	49	,	,	,
cord-301362-f3lp10lm	34	50	2006	2006	CD
cord-301362-f3lp10lm	34	51	)	)	-RRB-
cord-301362-f3lp10lm	34	52	.	.	.
cord-301362-f3lp10lm	35	1	Despite	despite	IN
cord-301362-f3lp10lm	35	2	several	several	JJ
cord-301362-f3lp10lm	35	3	differences	difference	NNS
cord-301362-f3lp10lm	35	4	among	among	IN
cord-301362-f3lp10lm	35	5	host	host	NN
cord-301362-f3lp10lm	35	6	range	range	NN
cord-301362-f3lp10lm	35	7	,	,	,
cord-301362-f3lp10lm	35	8	viral	viral	JJ
cord-301362-f3lp10lm	35	9	structure	structure	NN
cord-301362-f3lp10lm	35	10	,	,	,
cord-301362-f3lp10lm	35	11	genome	genome	NN
cord-301362-f3lp10lm	35	12	organization	organization	NN
cord-301362-f3lp10lm	35	13	or	or	CC
cord-301362-f3lp10lm	35	14	membrane	membrane	NN
cord-301362-f3lp10lm	35	15	-	-	HYPH
cord-301362-f3lp10lm	35	16	donor	donor	NN
cord-301362-f3lp10lm	35	17	organelles	organelle	NNS
cord-301362-f3lp10lm	35	18	from	from	IN
cord-301362-f3lp10lm	35	19	the	the	DT
cord-301362-f3lp10lm	35	20	cell	cell	NN
cord-301362-f3lp10lm	35	21	,	,	,
cord-301362-f3lp10lm	35	22	these	these	DT
cord-301362-f3lp10lm	35	23	analyses	analysis	NNS
cord-301362-f3lp10lm	35	24	revealed	reveal	VBD
cord-301362-f3lp10lm	35	25	that	that	IN
cord-301362-f3lp10lm	35	26	+	+	``
cord-301362-f3lp10lm	35	27	sRNA	srna	NN
cord-301362-f3lp10lm	35	28	viruses	virus	NNS
cord-301362-f3lp10lm	35	29	are	be	VBP
cord-301362-f3lp10lm	35	30	able	able	JJ
cord-301362-f3lp10lm	35	31	to	to	TO
cord-301362-f3lp10lm	35	32	induce	induce	VB
cord-301362-f3lp10lm	35	33	two	two	CD
cord-301362-f3lp10lm	35	34	types	type	NNS
cord-301362-f3lp10lm	35	35	of	of	IN
cord-301362-f3lp10lm	35	36	membranous	membranous	JJ
cord-301362-f3lp10lm	35	37	modifications	modification	NNS
cord-301362-f3lp10lm	35	38	as	as	IN
cord-301362-f3lp10lm	35	39	replicative	replicative	JJ
cord-301362-f3lp10lm	35	40	niches	niche	NNS
cord-301362-f3lp10lm	35	41	:	:	:
cord-301362-f3lp10lm	35	42	invaginated	invaginate	VBN
cord-301362-f3lp10lm	35	43	vesicles	vesicle	NNS
cord-301362-f3lp10lm	35	44	or	or	CC
cord-301362-f3lp10lm	35	45	spherules	spherule	NNS
cord-301362-f3lp10lm	35	46	or	or	CC
cord-301362-f3lp10lm	35	47	a	a	DT
cord-301362-f3lp10lm	35	48	double	double	JJ
cord-301362-f3lp10lm	35	49	membrane	membrane	NN
cord-301362-f3lp10lm	35	50	vesicle	vesicle	NN
cord-301362-f3lp10lm	35	51	type	type	NN
cord-301362-f3lp10lm	35	52	.	.	.
cord-301362-f3lp10lm	36	1	In	in	IN
cord-301362-f3lp10lm	36	2	this	this	DT
cord-301362-f3lp10lm	36	3	review	review	NN
cord-301362-f3lp10lm	36	4	we	-PRON-	PRP
cord-301362-f3lp10lm	36	5	will	will	MD
cord-301362-f3lp10lm	36	6	describe	describe	VB
cord-301362-f3lp10lm	36	7	,	,	,
cord-301362-f3lp10lm	36	8	employing	employ	VBG
cord-301362-f3lp10lm	36	9	a	a	DT
cord-301362-f3lp10lm	36	10	prototype	prototype	NN
cord-301362-f3lp10lm	36	11	,	,	,
cord-301362-f3lp10lm	36	12	well	well	RB
cord-301362-f3lp10lm	36	13	-	-	HYPH
cord-301362-f3lp10lm	36	14	studied	study	VBN
cord-301362-f3lp10lm	36	15	,	,	,
cord-301362-f3lp10lm	36	16	viral	viral	JJ
cord-301362-f3lp10lm	36	17	agent	agent	NN
cord-301362-f3lp10lm	36	18	for	for	IN
cord-301362-f3lp10lm	36	19	each	each	DT
cord-301362-f3lp10lm	36	20	type	type	NN
cord-301362-f3lp10lm	36	21	of	of	IN
cord-301362-f3lp10lm	36	22	membrane	membrane	NN
cord-301362-f3lp10lm	36	23	alteration	alteration	NN
cord-301362-f3lp10lm	36	24	,	,	,
cord-301362-f3lp10lm	36	25	how	how	WRB
cord-301362-f3lp10lm	36	26	the	the	DT
cord-301362-f3lp10lm	36	27	virus	virus	NN
cord-301362-f3lp10lm	36	28	builds	build	VBZ
cord-301362-f3lp10lm	36	29	its	-PRON-	PRP$
cord-301362-f3lp10lm	36	30	hideout	hideout	NN
cord-301362-f3lp10lm	36	31	to	to	TO
cord-301362-f3lp10lm	36	32	shelter	shelter	VB
cord-301362-f3lp10lm	36	33	from	from	IN
cord-301362-f3lp10lm	36	34	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	36	35	receptors	receptor	NNS
cord-301362-f3lp10lm	36	36	.	.	.
cord-301362-f3lp10lm	37	1	However	however	RB
cord-301362-f3lp10lm	37	2	,	,	,
cord-301362-f3lp10lm	37	3	a	a	DT
cord-301362-f3lp10lm	37	4	concern	concern	NN
cord-301362-f3lp10lm	37	5	arises	arise	VBZ
cord-301362-f3lp10lm	37	6	when	when	WRB
cord-301362-f3lp10lm	37	7	observing	observe	VBG
cord-301362-f3lp10lm	37	8	that	that	IN
cord-301362-f3lp10lm	37	9	while	while	IN
cord-301362-f3lp10lm	38	1	+	+	CC
cord-301362-f3lp10lm	39	1	sRNA	srna	NN
cord-301362-f3lp10lm	39	2	viruses	virus	NNS
cord-301362-f3lp10lm	39	3	build	build	VBP
cord-301362-f3lp10lm	39	4	their	-PRON-	PRP$
cord-301362-f3lp10lm	39	5	replication	replication	NN
cord-301362-f3lp10lm	39	6	niches	niche	NNS
cord-301362-f3lp10lm	39	7	associated	associate	VBN
cord-301362-f3lp10lm	39	8	to	to	IN
cord-301362-f3lp10lm	39	9	membranes	membrane	NNS
cord-301362-f3lp10lm	39	10	,	,	,
cord-301362-f3lp10lm	39	11	the	the	DT
cord-301362-f3lp10lm	39	12	host	host	NN
cord-301362-f3lp10lm	39	13	cells	cell	NNS
cord-301362-f3lp10lm	39	14	are	be	VBP
cord-301362-f3lp10lm	39	15	still	still	RB
cord-301362-f3lp10lm	39	16	able	able	JJ
cord-301362-f3lp10lm	39	17	to	to	TO
cord-301362-f3lp10lm	39	18	establish	establish	VB
cord-301362-f3lp10lm	39	19	an	an	DT
cord-301362-f3lp10lm	39	20	antiviral	antiviral	JJ
cord-301362-f3lp10lm	39	21	response	response	NN
cord-301362-f3lp10lm	39	22	,	,	,
cord-301362-f3lp10lm	39	23	mediated	mediate	VBN
cord-301362-f3lp10lm	39	24	by	by	IN
cord-301362-f3lp10lm	39	25	the	the	DT
cord-301362-f3lp10lm	39	26	cellular	cellular	JJ
cord-301362-f3lp10lm	39	27	receptors	receptor	NNS
cord-301362-f3lp10lm	39	28	that	that	WDT
cord-301362-f3lp10lm	39	29	the	the	DT
cord-301362-f3lp10lm	39	30	viruses	virus	NNS
cord-301362-f3lp10lm	39	31	are	be	VBP
cord-301362-f3lp10lm	39	32	intended	intend	VBN
cord-301362-f3lp10lm	39	33	to	to	TO
cord-301362-f3lp10lm	39	34	hide	hide	VB
cord-301362-f3lp10lm	39	35	from	from	IN
cord-301362-f3lp10lm	39	36	.	.	.
cord-301362-f3lp10lm	40	1	Regarding	regard	VBG
cord-301362-f3lp10lm	40	2	this	this	DT
cord-301362-f3lp10lm	40	3	important	important	JJ
cord-301362-f3lp10lm	40	4	question	question	NN
cord-301362-f3lp10lm	40	5	,	,	,
cord-301362-f3lp10lm	40	6	a	a	DT
cord-301362-f3lp10lm	40	7	recent	recent	JJ
cord-301362-f3lp10lm	40	8	proposed	propose	VBN
cord-301362-f3lp10lm	40	9	mechanism	mechanism	NN
cord-301362-f3lp10lm	40	10	will	will	MD
cord-301362-f3lp10lm	40	11	be	be	VB
cord-301362-f3lp10lm	40	12	included	include	VBN
cord-301362-f3lp10lm	40	13	to	to	TO
cord-301362-f3lp10lm	40	14	clarify	clarify	VB
cord-301362-f3lp10lm	40	15	this	this	DT
cord-301362-f3lp10lm	40	16	intriguing	intriguing	JJ
cord-301362-f3lp10lm	40	17	crossroad	crossroad	NN
cord-301362-f3lp10lm	40	18	,	,	,
cord-301362-f3lp10lm	40	19	a	a	DT
cord-301362-f3lp10lm	40	20	paradigmatic	paradigmatic	JJ
cord-301362-f3lp10lm	40	21	scenario	scenario	NN
cord-301362-f3lp10lm	40	22	of	of	IN
cord-301362-f3lp10lm	40	23	virus	virus	NN
cord-301362-f3lp10lm	40	24	-	-	HYPH
cord-301362-f3lp10lm	40	25	host	host	NN
cord-301362-f3lp10lm	40	26	cell	cell	NN
cord-301362-f3lp10lm	40	27	co	co	NN
cord-301362-f3lp10lm	40	28	-	-	JJ
cord-301362-f3lp10lm	40	29	evolution	evolution	JJ
cord-301362-f3lp10lm	40	30	process	process	NN
cord-301362-f3lp10lm	40	31	.	.	.
cord-301362-f3lp10lm	41	1	TLRs	TLRs	NNP
cord-301362-f3lp10lm	41	2	are	be	VBP
cord-301362-f3lp10lm	41	3	type	type	NN
cord-301362-f3lp10lm	41	4	I	-PRON-	PRP
cord-301362-f3lp10lm	41	5	transmembrane	transmembrane	NNP
cord-301362-f3lp10lm	41	6	domain	domain	NN
cord-301362-f3lp10lm	41	7	family	family	NN
cord-301362-f3lp10lm	41	8	of	of	IN
cord-301362-f3lp10lm	41	9	proteins	protein	NNS
cord-301362-f3lp10lm	41	10	with	with	IN
cord-301362-f3lp10lm	41	11	a	a	DT
cord-301362-f3lp10lm	41	12	tripartite	tripartite	JJ
cord-301362-f3lp10lm	41	13	structure	structure	NN
cord-301362-f3lp10lm	41	14	.	.	.
cord-301362-f3lp10lm	42	1	They	-PRON-	PRP
cord-301362-f3lp10lm	42	2	consist	consist	VBP
cord-301362-f3lp10lm	42	3	of	of	IN
cord-301362-f3lp10lm	42	4	an	an	DT
cord-301362-f3lp10lm	42	5	amino	amino	NN
cord-301362-f3lp10lm	42	6	(	(	-LRB-
cord-301362-f3lp10lm	42	7	N)terminal	n)terminal	JJ
cord-301362-f3lp10lm	42	8	ectodomain	ectodomain	NN
cord-301362-f3lp10lm	42	9	containing	contain	VBG
cord-301362-f3lp10lm	42	10	leucine	leucine	NN
cord-301362-f3lp10lm	42	11	rich	rich	NNP
cord-301362-f3lp10lm	42	12	repeats	repeat	VBZ
cord-301362-f3lp10lm	42	13	responsible	responsible	JJ
cord-301362-f3lp10lm	42	14	for	for	IN
cord-301362-f3lp10lm	42	15	ligand	ligand	NN
cord-301362-f3lp10lm	42	16	recognition	recognition	NN
cord-301362-f3lp10lm	42	17	,	,	,
cord-301362-f3lp10lm	42	18	a	a	DT
cord-301362-f3lp10lm	42	19	single	single	JJ
cord-301362-f3lp10lm	42	20	transmembrane	transmembrane	NN
cord-301362-f3lp10lm	42	21	spanning	span	VBG
cord-301362-f3lp10lm	42	22	region	region	NN
cord-301362-f3lp10lm	42	23	and	and	CC
cord-301362-f3lp10lm	42	24	a	a	DT
cord-301362-f3lp10lm	42	25	carboxyl	carboxyl	NN
cord-301362-f3lp10lm	42	26	(	(	-LRB-
cord-301362-f3lp10lm	42	27	C)-terminal	C)-terminal	NNP
cord-301362-f3lp10lm	42	28	globular	globular	JJ
cord-301362-f3lp10lm	42	29	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	42	30	Tolllike	Tolllike	NNP
cord-301362-f3lp10lm	42	31	/	/	SYM
cord-301362-f3lp10lm	42	32	interleukin-1	interleukin-1	NNP
cord-301362-f3lp10lm	42	33	(	(	-LRB-
cord-301362-f3lp10lm	42	34	IL-1	IL-1	NNP
cord-301362-f3lp10lm	42	35	)	)	-RRB-
cord-301362-f3lp10lm	42	36	receptor	receptor	NN
cord-301362-f3lp10lm	42	37	(	(	-LRB-
cord-301362-f3lp10lm	42	38	TIR	TIR	NNP
cord-301362-f3lp10lm	42	39	)	)	-RRB-
cord-301362-f3lp10lm	42	40	involved	involve	VBN
cord-301362-f3lp10lm	42	41	in	in	IN
cord-301362-f3lp10lm	42	42	downstream	downstream	JJ
cord-301362-f3lp10lm	42	43	signaling	signal	VBG
cord-301362-f3lp10lm	42	44	activation	activation	NN
cord-301362-f3lp10lm	42	45	(	(	-LRB-
cord-301362-f3lp10lm	42	46	Gay	Gay	NNP
cord-301362-f3lp10lm	42	47	and	and	CC
cord-301362-f3lp10lm	42	48	Gangloff	Gangloff	NNP
cord-301362-f3lp10lm	42	49	,	,	,
cord-301362-f3lp10lm	42	50	2007	2007	CD
cord-301362-f3lp10lm	42	51	)	)	-RRB-
cord-301362-f3lp10lm	42	52	.	.	.
cord-301362-f3lp10lm	43	1	TLRs	tlr	NNS
cord-301362-f3lp10lm	43	2	recognize	recognize	VBP
cord-301362-f3lp10lm	43	3	pathogen	pathogen	NN
cord-301362-f3lp10lm	43	4	-	-	HYPH
cord-301362-f3lp10lm	43	5	associated	associate	VBN
cord-301362-f3lp10lm	43	6	molecular	molecular	JJ
cord-301362-f3lp10lm	43	7	patterns	pattern	NNS
cord-301362-f3lp10lm	43	8	(	(	-LRB-
cord-301362-f3lp10lm	43	9	PAMPs	pamp	NNS
cord-301362-f3lp10lm	43	10	)	)	-RRB-
cord-301362-f3lp10lm	43	11	derived	derive	VBN
cord-301362-f3lp10lm	43	12	from	from	IN
cord-301362-f3lp10lm	43	13	microorganisms	microorganism	NNS
cord-301362-f3lp10lm	43	14	and	and	CC
cord-301362-f3lp10lm	43	15	induce	induce	VB
cord-301362-f3lp10lm	43	16	an	an	DT
cord-301362-f3lp10lm	43	17	inflammatory	inflammatory	JJ
cord-301362-f3lp10lm	43	18	response	response	NN
cord-301362-f3lp10lm	43	19	.	.	.
cord-301362-f3lp10lm	44	1	Due	due	IN
cord-301362-f3lp10lm	44	2	to	to	IN
cord-301362-f3lp10lm	44	3	its	-PRON-	PRP$
cord-301362-f3lp10lm	44	4	ability	ability	NN
cord-301362-f3lp10lm	44	5	to	to	TO
cord-301362-f3lp10lm	44	6	recognize	recognize	VB
cord-301362-f3lp10lm	44	7	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	44	8	molecules	molecule	NNS
cord-301362-f3lp10lm	44	9	,	,	,
cord-301362-f3lp10lm	44	10	the	the	DT
cord-301362-f3lp10lm	44	11	TLR3	TLR3	NNP
cord-301362-f3lp10lm	44	12	is	be	VBZ
cord-301362-f3lp10lm	44	13	the	the	DT
cord-301362-f3lp10lm	44	14	"	"	``
cord-301362-f3lp10lm	44	15	cellular	cellular	JJ
cord-301362-f3lp10lm	44	16	major	major	JJ
cord-301362-f3lp10lm	44	17	sentinel	sentinel	NN
cord-301362-f3lp10lm	44	18	"	"	''
cord-301362-f3lp10lm	44	19	against	against	IN
cord-301362-f3lp10lm	44	20	these	these	DT
cord-301362-f3lp10lm	44	21	agents	agent	NNS
cord-301362-f3lp10lm	44	22	(	(	-LRB-
cord-301362-f3lp10lm	44	23	Thompson	Thompson	NNP
cord-301362-f3lp10lm	44	24	et	et	NNP
cord-301362-f3lp10lm	44	25	al	al	NNP
cord-301362-f3lp10lm	44	26	.	.	NNP
cord-301362-f3lp10lm	44	27	,	,	,
cord-301362-f3lp10lm	44	28	2011	2011	CD
cord-301362-f3lp10lm	44	29	)	)	-RRB-
cord-301362-f3lp10lm	44	30	.	.	.
cord-301362-f3lp10lm	45	1	TLR3	TLR3	NNP
cord-301362-f3lp10lm	45	2	recognizes	recognize	VBZ
cord-301362-f3lp10lm	45	3	genomic	genomic	JJ
cord-301362-f3lp10lm	45	4	dsRNA	dsrna	NN
cord-301362-f3lp10lm	45	5	or	or	CC
cord-301362-f3lp10lm	45	6	dsRNA	dsrna	NN
cord-301362-f3lp10lm	45	7	replication	replication	NN
cord-301362-f3lp10lm	45	8	intermediates	intermediate	NNS
cord-301362-f3lp10lm	45	9	present	present	JJ
cord-301362-f3lp10lm	45	10	in	in	IN
cord-301362-f3lp10lm	45	11	virus	virus	NN
cord-301362-f3lp10lm	45	12	-	-	HYPH
cord-301362-f3lp10lm	45	13	infected	infect	VBN
cord-301362-f3lp10lm	45	14	cells	cell	NNS
cord-301362-f3lp10lm	45	15	independently	independently	RB
cord-301362-f3lp10lm	45	16	of	of	IN
cord-301362-f3lp10lm	45	17	the	the	DT
cord-301362-f3lp10lm	45	18	sequence	sequence	NN
cord-301362-f3lp10lm	46	1	(	(	-LRB-
cord-301362-f3lp10lm	46	2	Alexopoulou	Alexopoulou	NNP
cord-301362-f3lp10lm	46	3	et	et	NNP
cord-301362-f3lp10lm	46	4	al	al	NNP
cord-301362-f3lp10lm	46	5	.	.	NNP
cord-301362-f3lp10lm	46	6	,	,	,
cord-301362-f3lp10lm	46	7	2001	2001	CD
cord-301362-f3lp10lm	46	8	)	)	-RRB-
cord-301362-f3lp10lm	46	9	.	.	.
cord-301362-f3lp10lm	47	1	TLR3	TLR3	NNP
cord-301362-f3lp10lm	47	2	is	be	VBZ
cord-301362-f3lp10lm	47	3	broadly	broadly	RB
cord-301362-f3lp10lm	47	4	expressed	express	VBN
cord-301362-f3lp10lm	47	5	in	in	IN
cord-301362-f3lp10lm	47	6	immune	immune	JJ
cord-301362-f3lp10lm	47	7	and	and	CC
cord-301362-f3lp10lm	47	8	non	non	JJ
cord-301362-f3lp10lm	47	9	-	-	JJ
cord-301362-f3lp10lm	47	10	immune	immune	JJ
cord-301362-f3lp10lm	47	11	cells	cell	NNS
cord-301362-f3lp10lm	47	12	and	and	CC
cord-301362-f3lp10lm	47	13	has	have	VBZ
cord-301362-f3lp10lm	47	14	a	a	DT
cord-301362-f3lp10lm	47	15	high	high	JJ
cord-301362-f3lp10lm	47	16	level	level	NN
cord-301362-f3lp10lm	47	17	of	of	IN
cord-301362-f3lp10lm	47	18	conservation	conservation	NN
cord-301362-f3lp10lm	47	19	among	among	IN
cord-301362-f3lp10lm	47	20	vertebrates	vertebrate	NNS
cord-301362-f3lp10lm	47	21	(	(	-LRB-
cord-301362-f3lp10lm	47	22	Mikami	Mikami	NNP
cord-301362-f3lp10lm	47	23	et	et	FW
cord-301362-f3lp10lm	47	24	al	al	NNP
cord-301362-f3lp10lm	47	25	.	.	NNP
cord-301362-f3lp10lm	47	26	,	,	,
cord-301362-f3lp10lm	47	27	2012	2012	CD
cord-301362-f3lp10lm	47	28	)	)	-RRB-
cord-301362-f3lp10lm	47	29	.	.	.
cord-301362-f3lp10lm	48	1	After	after	IN
cord-301362-f3lp10lm	48	2	synthesis	synthesis	NN
cord-301362-f3lp10lm	48	3	,	,	,
cord-301362-f3lp10lm	48	4	TLR3	TLR3	NNP
cord-301362-f3lp10lm	48	5	is	be	VBZ
cord-301362-f3lp10lm	48	6	retained	retain	VBN
cord-301362-f3lp10lm	48	7	in	in	IN
cord-301362-f3lp10lm	48	8	the	the	DT
cord-301362-f3lp10lm	48	9	endoplasmic	endoplasmic	NN
cord-301362-f3lp10lm	48	10	reticulum	reticulum	NN
cord-301362-f3lp10lm	48	11	(	(	-LRB-
cord-301362-f3lp10lm	48	12	ER	ER	NNP
cord-301362-f3lp10lm	48	13	)	)	-RRB-
cord-301362-f3lp10lm	48	14	in	in	IN
cord-301362-f3lp10lm	48	15	unstimulated	unstimulated	JJ
cord-301362-f3lp10lm	48	16	cells	cell	NNS
cord-301362-f3lp10lm	48	17	and	and	CC
cord-301362-f3lp10lm	48	18	translocate	translocate	VB
cord-301362-f3lp10lm	48	19	to	to	IN
cord-301362-f3lp10lm	48	20	the	the	DT
cord-301362-f3lp10lm	48	21	endolysosomal	endolysosomal	NNP
cord-301362-f3lp10lm	48	22	compartment	compartment	NN
cord-301362-f3lp10lm	48	23	when	when	WRB
cord-301362-f3lp10lm	48	24	a	a	DT
cord-301362-f3lp10lm	48	25	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	48	26	-	-	HYPH
cord-301362-f3lp10lm	48	27	stimulation	stimulation	NN
cord-301362-f3lp10lm	48	28	occurs	occur	VBZ
cord-301362-f3lp10lm	48	29	,	,	,
cord-301362-f3lp10lm	48	30	in	in	IN
cord-301362-f3lp10lm	48	31	a	a	DT
cord-301362-f3lp10lm	48	32	process	process	NN
cord-301362-f3lp10lm	48	33	where	where	WRB
cord-301362-f3lp10lm	48	34	the	the	DT
cord-301362-f3lp10lm	48	35	ER	ER	NNP
cord-301362-f3lp10lm	48	36	membrane	membrane	NN
cord-301362-f3lp10lm	48	37	protein	protein	NN
cord-301362-f3lp10lm	48	38	uncoordinated	uncoordinated	JJ
cord-301362-f3lp10lm	48	39	93B1	93b1	CD
cord-301362-f3lp10lm	48	40	and	and	CC
cord-301362-f3lp10lm	48	41	the	the	DT
cord-301362-f3lp10lm	48	42	leucine	leucine	NN
cord-301362-f3lp10lm	48	43	-	-	HYPH
cord-301362-f3lp10lm	48	44	rich	rich	JJ
cord-301362-f3lp10lm	48	45	repeat	repeat	NN
cord-301362-f3lp10lm	48	46	containing	contain	VBG
cord-301362-f3lp10lm	48	47	-	-	HYPH
cord-301362-f3lp10lm	48	48	protein	protein	NN
cord-301362-f3lp10lm	48	49	59	59	CD
cord-301362-f3lp10lm	48	50	/	/	SYM
cord-301362-f3lp10lm	48	51	p34	p34	CD
cord-301362-f3lp10lm	48	52	play	play	VBP
cord-301362-f3lp10lm	48	53	an	an	DT
cord-301362-f3lp10lm	48	54	important	important	JJ
cord-301362-f3lp10lm	48	55	role	role	NN
cord-301362-f3lp10lm	48	56	(	(	-LRB-
cord-301362-f3lp10lm	48	57	Kim	Kim	NNP
cord-301362-f3lp10lm	48	58	et	et	NNP
cord-301362-f3lp10lm	48	59	al	al	NNP
cord-301362-f3lp10lm	48	60	.	.	NNP
cord-301362-f3lp10lm	48	61	,	,	,
cord-301362-f3lp10lm	48	62	2008	2008	CD
cord-301362-f3lp10lm	48	63	;	;	.
cord-301362-f3lp10lm	49	1	Tatematsu	Tatematsu	NNP
cord-301362-f3lp10lm	49	2	et	et	NNP
cord-301362-f3lp10lm	49	3	al	al	NNP
cord-301362-f3lp10lm	49	4	.	.	NNP
cord-301362-f3lp10lm	49	5	,	,	,
cord-301362-f3lp10lm	49	6	2015	2015	CD
cord-301362-f3lp10lm	49	7	)	)	-RRB-
cord-301362-f3lp10lm	49	8	.	.	.
cord-301362-f3lp10lm	50	1	Although	although	IN
cord-301362-f3lp10lm	50	2	it	-PRON-	PRP
cord-301362-f3lp10lm	50	3	has	have	VBZ
cord-301362-f3lp10lm	50	4	been	be	VBN
cord-301362-f3lp10lm	50	5	shown	show	VBN
cord-301362-f3lp10lm	50	6	that	that	IN
cord-301362-f3lp10lm	50	7	dsRNA	dsrna	NN
cord-301362-f3lp10lm	50	8	-	-	HYPH
cord-301362-f3lp10lm	50	9	sensing	sense	VBG
cord-301362-f3lp10lm	50	10	TLRs	tlr	NNS
cord-301362-f3lp10lm	50	11	are	be	VBP
cord-301362-f3lp10lm	50	12	translocated	translocate	VBN
cord-301362-f3lp10lm	50	13	from	from	IN
cord-301362-f3lp10lm	50	14	the	the	DT
cord-301362-f3lp10lm	50	15	ER	ER	NNP
cord-301362-f3lp10lm	50	16	to	to	IN
cord-301362-f3lp10lm	50	17	lysosomes	lysosome	NNS
cord-301362-f3lp10lm	50	18	,	,	,
cord-301362-f3lp10lm	50	19	upon	upon	IN
cord-301362-f3lp10lm	50	20	ligand	ligand	NN
cord-301362-f3lp10lm	50	21	stimulation	stimulation	NN
cord-301362-f3lp10lm	50	22	,	,	,
cord-301362-f3lp10lm	50	23	the	the	DT
cord-301362-f3lp10lm	50	24	molecular	molecular	JJ
cord-301362-f3lp10lm	50	25	mechanism	mechanism	NN
cord-301362-f3lp10lm	50	26	of	of	IN
cord-301362-f3lp10lm	50	27	ligand	ligand	NN
cord-301362-f3lp10lm	50	28	-	-	HYPH
cord-301362-f3lp10lm	50	29	dependent	dependent	JJ
cord-301362-f3lp10lm	50	30	trafficking	trafficking	NN
cord-301362-f3lp10lm	50	31	of	of	IN
cord-301362-f3lp10lm	50	32	the	the	DT
cord-301362-f3lp10lm	50	33	TLRs	tlr	NNS
cord-301362-f3lp10lm	50	34	is	be	VBZ
cord-301362-f3lp10lm	50	35	largely	largely	RB
cord-301362-f3lp10lm	50	36	unknown	unknown	JJ
cord-301362-f3lp10lm	50	37	.	.	.
cord-301362-f3lp10lm	51	1	Once	once	RB
cord-301362-f3lp10lm	51	2	within	within	IN
cord-301362-f3lp10lm	51	3	the	the	DT
cord-301362-f3lp10lm	51	4	endolysosomal	endolysosomal	JJ
cord-301362-f3lp10lm	51	5	compartment	compartment	NN
cord-301362-f3lp10lm	51	6	,	,	,
cord-301362-f3lp10lm	51	7	TLR3	TLR3	NNP
cord-301362-f3lp10lm	51	8	is	be	VBZ
cord-301362-f3lp10lm	51	9	able	able	JJ
cord-301362-f3lp10lm	51	10	to	to	TO
cord-301362-f3lp10lm	51	11	recognize	recognize	VB
cord-301362-f3lp10lm	51	12	dsRNA	dsrna	NN
cord-301362-f3lp10lm	51	13	longer	long	RBR
cord-301362-f3lp10lm	51	14	than	than	IN
cord-301362-f3lp10lm	51	15	∼40	∼40	NNP
cord-301362-f3lp10lm	51	16	bp	bp	NNP
cord-301362-f3lp10lm	51	17	for	for	IN
cord-301362-f3lp10lm	51	18	robust	robust	JJ
cord-301362-f3lp10lm	51	19	stimulation	stimulation	NN
cord-301362-f3lp10lm	51	20	,	,	,
cord-301362-f3lp10lm	51	21	largely	largely	RB
cord-301362-f3lp10lm	51	22	through	through	IN
cord-301362-f3lp10lm	51	23	the	the	DT
cord-301362-f3lp10lm	51	24	minor	minor	JJ
cord-301362-f3lp10lm	51	25	groove	groove	NN
cord-301362-f3lp10lm	51	26	and	and	CC
cord-301362-f3lp10lm	51	27	the	the	DT
cord-301362-f3lp10lm	51	28	nearby	nearby	JJ
cord-301362-f3lp10lm	51	29	phosphate	phosphate	NN
cord-301362-f3lp10lm	51	30	backbone	backbone	NN
cord-301362-f3lp10lm	51	31	explaining	explain	VBG
cord-301362-f3lp10lm	51	32	why	why	WRB
cord-301362-f3lp10lm	51	33	recognition	recognition	NN
cord-301362-f3lp10lm	51	34	is	be	VBZ
cord-301362-f3lp10lm	51	35	independent	independent	JJ
cord-301362-f3lp10lm	51	36	of	of	IN
cord-301362-f3lp10lm	51	37	RNA	RNA	NNP
cord-301362-f3lp10lm	51	38	sequence	sequence	NN
cord-301362-f3lp10lm	51	39	.	.	.
cord-301362-f3lp10lm	52	1	Genomic	genomic	JJ
cord-301362-f3lp10lm	52	2	nucleic	nucleic	JJ
cord-301362-f3lp10lm	52	3	acid	acid	NN
cord-301362-f3lp10lm	52	4	material	material	NN
cord-301362-f3lp10lm	52	5	from	from	IN
cord-301362-f3lp10lm	52	6	internalized	internalize	VBN
cord-301362-f3lp10lm	52	7	dsRNA	dsrna	NN
cord-301362-f3lp10lm	52	8	viruses	virus	NNS
cord-301362-f3lp10lm	52	9	such	such	JJ
cord-301362-f3lp10lm	52	10	as	as	IN
cord-301362-f3lp10lm	52	11	reoviruses	reovirus	NNS
cord-301362-f3lp10lm	52	12	consisting	consist	VBG
cord-301362-f3lp10lm	52	13	of	of	IN
cord-301362-f3lp10lm	52	14	long	long	JJ
cord-301362-f3lp10lm	52	15	stretches	stretch	NNS
cord-301362-f3lp10lm	52	16	of	of	IN
cord-301362-f3lp10lm	52	17	dsRNA	dsrna	NN
cord-301362-f3lp10lm	52	18	represent	represent	VBP
cord-301362-f3lp10lm	52	19	molecular	molecular	JJ
cord-301362-f3lp10lm	52	20	structures	structure	NNS
cord-301362-f3lp10lm	52	21	that	that	WDT
cord-301362-f3lp10lm	52	22	are	be	VBP
cord-301362-f3lp10lm	52	23	absent	absent	JJ
cord-301362-f3lp10lm	52	24	in	in	IN
cord-301362-f3lp10lm	52	25	non	non	JJ
cord-301362-f3lp10lm	52	26	-	-	JJ
cord-301362-f3lp10lm	52	27	infected	infected	JJ
cord-301362-f3lp10lm	52	28	eukaryotic	eukaryotic	JJ
cord-301362-f3lp10lm	52	29	cells	cell	NNS
cord-301362-f3lp10lm	52	30	.	.	.
cord-301362-f3lp10lm	53	1	Endogenous	endogenous	JJ
cord-301362-f3lp10lm	53	2	RNAs	rna	NNS
cord-301362-f3lp10lm	53	3	forming	form	VBG
cord-301362-f3lp10lm	53	4	secondary	secondary	JJ
cord-301362-f3lp10lm	53	5	double	double	RB
cord-301362-f3lp10lm	53	6	-	-	HYPH
cord-301362-f3lp10lm	53	7	stranded	strand	VBN
cord-301362-f3lp10lm	53	8	structures	structure	NNS
cord-301362-f3lp10lm	53	9	that	that	WDT
cord-301362-f3lp10lm	53	10	are	be	VBP
cord-301362-f3lp10lm	53	11	released	release	VBN
cord-301362-f3lp10lm	53	12	after	after	IN
cord-301362-f3lp10lm	53	13	necrosis	necrosis	NN
cord-301362-f3lp10lm	53	14	and	and	CC
cord-301362-f3lp10lm	53	15	tissue	tissue	NN
cord-301362-f3lp10lm	53	16	damage	damage	NN
cord-301362-f3lp10lm	53	17	after	after	IN
cord-301362-f3lp10lm	53	18	viral	viral	JJ
cord-301362-f3lp10lm	53	19	infection	infection	NN
cord-301362-f3lp10lm	53	20	represent	represent	VBP
cord-301362-f3lp10lm	53	21	another	another	DT
cord-301362-f3lp10lm	53	22	source	source	NN
cord-301362-f3lp10lm	53	23	of	of	IN
cord-301362-f3lp10lm	53	24	dsRNA	dsrna	NN
cord-301362-f3lp10lm	53	25	molecules	molecule	NNS
cord-301362-f3lp10lm	53	26	reaching	reach	VBG
cord-301362-f3lp10lm	53	27	the	the	DT
cord-301362-f3lp10lm	53	28	endosomes	endosome	NNS
cord-301362-f3lp10lm	53	29	,	,	,
cord-301362-f3lp10lm	53	30	inducing	induce	VBG
cord-301362-f3lp10lm	53	31	host	host	NN
cord-301362-f3lp10lm	53	32	-	-	HYPH
cord-301362-f3lp10lm	53	33	derived	derive	VBN
cord-301362-f3lp10lm	53	34	dsRNA	dsrna	RB
cord-301362-f3lp10lm	53	35	-	-	HYPH
cord-301362-f3lp10lm	53	36	mediated	mediate	VBN
cord-301362-f3lp10lm	53	37	inflammatory	inflammatory	JJ
cord-301362-f3lp10lm	53	38	responses	response	NNS
cord-301362-f3lp10lm	53	39	through	through	IN
cord-301362-f3lp10lm	53	40	TLR-3	TLR-3	NNP
cord-301362-f3lp10lm	53	41	recognition	recognition	NN
cord-301362-f3lp10lm	53	42	(	(	-LRB-
cord-301362-f3lp10lm	53	43	Kawai	Kawai	NNP
cord-301362-f3lp10lm	53	44	and	and	CC
cord-301362-f3lp10lm	53	45	Akira	Akira	NNP
cord-301362-f3lp10lm	53	46	,	,	,
cord-301362-f3lp10lm	53	47	2010	2010	CD
cord-301362-f3lp10lm	53	48	)	)	-RRB-
cord-301362-f3lp10lm	53	49	.	.	.
cord-301362-f3lp10lm	54	1	However	however	RB
cord-301362-f3lp10lm	54	2	,	,	,
cord-301362-f3lp10lm	54	3	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	54	4	-	-	:
cord-301362-f3lp10lm	54	5	TLR3	tlr3	JJ
cord-301362-f3lp10lm	54	6	high	high	JJ
cord-301362-f3lp10lm	54	7	affinity	affinity	NN
cord-301362-f3lp10lm	54	8	binding	binding	NN
cord-301362-f3lp10lm	54	9	is	be	VBZ
cord-301362-f3lp10lm	54	10	strikingly	strikingly	RB
cord-301362-f3lp10lm	54	11	dependent	dependent	JJ
cord-301362-f3lp10lm	54	12	on	on	IN
cord-301362-f3lp10lm	54	13	the	the	DT
cord-301362-f3lp10lm	54	14	acidic	acidic	JJ
cord-301362-f3lp10lm	54	15	environment	environment	NN
cord-301362-f3lp10lm	54	16	since	since	IN
cord-301362-f3lp10lm	54	17	protonation	protonation	NN
cord-301362-f3lp10lm	54	18	of	of	IN
cord-301362-f3lp10lm	54	19	histidine	histidine	NN
cord-301362-f3lp10lm	54	20	on	on	IN
cord-301362-f3lp10lm	54	21	the	the	DT
cord-301362-f3lp10lm	54	22	TLR3	TLR3	NNP
cord-301362-f3lp10lm	54	23	surface	surface	NN
cord-301362-f3lp10lm	54	24	is	be	VBZ
cord-301362-f3lp10lm	54	25	required	require	VBN
cord-301362-f3lp10lm	54	26	to	to	TO
cord-301362-f3lp10lm	54	27	allow	allow	VB
cord-301362-f3lp10lm	54	28	ionic	ionic	JJ
cord-301362-f3lp10lm	54	29	interaction	interaction	NN
cord-301362-f3lp10lm	54	30	.	.	.
cord-301362-f3lp10lm	55	1	The	the	DT
cord-301362-f3lp10lm	55	2	dsRNA	dsrna	NN
cord-301362-f3lp10lm	55	3	-	-	:
cord-301362-f3lp10lm	55	4	TLR3	tlr3	JJ
cord-301362-f3lp10lm	55	5	structure	structure	NN
cord-301362-f3lp10lm	55	6	has	have	VBZ
cord-301362-f3lp10lm	55	7	been	be	VBN
cord-301362-f3lp10lm	55	8	recently	recently	RB
cord-301362-f3lp10lm	55	9	elucidated	elucidate	VBN
cord-301362-f3lp10lm	55	10	revealing	reveal	VBG
cord-301362-f3lp10lm	55	11	that	that	IN
cord-301362-f3lp10lm	55	12	the	the	DT
cord-301362-f3lp10lm	55	13	dsRNA	dsrna	NN
cord-301362-f3lp10lm	55	14	molecules	molecule	NNS
cord-301362-f3lp10lm	55	15	induce	induce	VBP
cord-301362-f3lp10lm	55	16	the	the	DT
cord-301362-f3lp10lm	55	17	dimerization	dimerization	NN
cord-301362-f3lp10lm	55	18	of	of	IN
cord-301362-f3lp10lm	55	19	TLR3	TLR3	NNP
cord-301362-f3lp10lm	55	20	ectodomain	ectodomain	NNP
cord-301362-f3lp10lm	55	21	(	(	-LRB-
cord-301362-f3lp10lm	55	22	ECD	ECD	NNP
cord-301362-f3lp10lm	55	23	)	)	-RRB-
cord-301362-f3lp10lm	55	24	inside	inside	IN
cord-301362-f3lp10lm	55	25	the	the	DT
cord-301362-f3lp10lm	55	26	vesicle	vesicle	NN
cord-301362-f3lp10lm	56	1	(	(	-LRB-
cord-301362-f3lp10lm	56	2	Liu	Liu	NNP
cord-301362-f3lp10lm	56	3	et	et	NNP
cord-301362-f3lp10lm	56	4	al	al	NNP
cord-301362-f3lp10lm	56	5	.	.	NNP
cord-301362-f3lp10lm	56	6	,	,	,
cord-301362-f3lp10lm	56	7	2008	2008	CD
cord-301362-f3lp10lm	56	8	)	)	-RRB-
cord-301362-f3lp10lm	56	9	.	.	.
cord-301362-f3lp10lm	57	1	Moreover	moreover	RB
cord-301362-f3lp10lm	57	2	,	,	,
cord-301362-f3lp10lm	57	3	the	the	DT
cord-301362-f3lp10lm	57	4	proximity	proximity	NN
cord-301362-f3lp10lm	57	5	of	of	IN
cord-301362-f3lp10lm	57	6	two	two	CD
cord-301362-f3lp10lm	57	7	ECD	ECD	NNP
cord-301362-f3lp10lm	57	8	generates	generate	VBZ
cord-301362-f3lp10lm	57	9	the	the	DT
cord-301362-f3lp10lm	57	10	dimerization	dimerization	NN
cord-301362-f3lp10lm	57	11	of	of	IN
cord-301362-f3lp10lm	57	12	the	the	DT
cord-301362-f3lp10lm	57	13	cytosolic	cytosolic	JJ
cord-301362-f3lp10lm	57	14	TIR	TIR	NNP
cord-301362-f3lp10lm	57	15	domains	domain	NNS
cord-301362-f3lp10lm	57	16	.	.	.
cord-301362-f3lp10lm	58	1	Additionally	additionally	RB
cord-301362-f3lp10lm	58	2	to	to	TO
cord-301362-f3lp10lm	58	3	recognition	recognition	VB
cord-301362-f3lp10lm	58	4	and	and	CC
cord-301362-f3lp10lm	58	5	dimerization	dimerization	NN
cord-301362-f3lp10lm	58	6	,	,	,
cord-301362-f3lp10lm	58	7	phosphorylation	phosphorylation	NN
cord-301362-f3lp10lm	58	8	of	of	IN
cord-301362-f3lp10lm	58	9	the	the	DT
cord-301362-f3lp10lm	58	10	Tyr	Tyr	NNP
cord-301362-f3lp10lm	58	11	759	759	CD
cord-301362-f3lp10lm	58	12	and	and	CC
cord-301362-f3lp10lm	58	13	Tyr	Tyr	NNP
cord-301362-f3lp10lm	58	14	858	858	CD
cord-301362-f3lp10lm	58	15	residues	residue	NNS
cord-301362-f3lp10lm	58	16	in	in	IN
cord-301362-f3lp10lm	58	17	the	the	DT
cord-301362-f3lp10lm	58	18	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	58	19	domain	domain	NN
cord-301362-f3lp10lm	58	20	of	of	IN
cord-301362-f3lp10lm	58	21	TLR3	TLR3	NNP
cord-301362-f3lp10lm	58	22	are	be	VBP
cord-301362-f3lp10lm	58	23	required	require	VBN
cord-301362-f3lp10lm	58	24	for	for	IN
cord-301362-f3lp10lm	58	25	triggering	trigger	VBG
cord-301362-f3lp10lm	58	26	the	the	DT
cord-301362-f3lp10lm	58	27	recruitment	recruitment	NN
cord-301362-f3lp10lm	58	28	of	of	IN
cord-301362-f3lp10lm	58	29	TIR	TIR	NNP
cord-301362-f3lp10lm	58	30	domaincontaining	domaincontaining	NN
cord-301362-f3lp10lm	58	31	adaptor	adaptor	NN
cord-301362-f3lp10lm	58	32	protein	protein	NN
cord-301362-f3lp10lm	58	33	interferon	interferon	NNP
cord-301362-f3lp10lm	58	34	-	-	HYPH
cord-301362-f3lp10lm	58	35	β	β	NNP
cord-301362-f3lp10lm	58	36	(	(	-LRB-
cord-301362-f3lp10lm	58	37	TRIF	TRIF	NNP
cord-301362-f3lp10lm	58	38	)	)	-RRB-
cord-301362-f3lp10lm	58	39	to	to	IN
cord-301362-f3lp10lm	58	40	the	the	DT
cord-301362-f3lp10lm	58	41	TIR	TIR	NNP
cord-301362-f3lp10lm	58	42	domain	domain	NN
cord-301362-f3lp10lm	58	43	of	of	IN
cord-301362-f3lp10lm	58	44	TLR3	TLR3	NNP
cord-301362-f3lp10lm	59	1	(	(	-LRB-
cord-301362-f3lp10lm	59	2	Sarkar	Sarkar	NNP
cord-301362-f3lp10lm	59	3	et	et	FW
cord-301362-f3lp10lm	59	4	al	al	NNP
cord-301362-f3lp10lm	59	5	.	.	NNP
cord-301362-f3lp10lm	59	6	,	,	,
cord-301362-f3lp10lm	59	7	2007	2007	CD
cord-301362-f3lp10lm	59	8	)	)	-RRB-
cord-301362-f3lp10lm	59	9	.	.	.
cord-301362-f3lp10lm	60	1	Finally	finally	RB
cord-301362-f3lp10lm	60	2	,	,	,
cord-301362-f3lp10lm	60	3	TRIF	TRIF	NNP
cord-301362-f3lp10lm	60	4	recruitment	recruitment	NN
cord-301362-f3lp10lm	60	5	results	result	VBZ
cord-301362-f3lp10lm	60	6	in	in	IN
cord-301362-f3lp10lm	60	7	stimulation	stimulation	NN
cord-301362-f3lp10lm	60	8	of	of	IN
cord-301362-f3lp10lm	60	9	the	the	DT
cord-301362-f3lp10lm	60	10	transcription	transcription	NN
cord-301362-f3lp10lm	60	11	factors	factor	NNS
cord-301362-f3lp10lm	60	12	IRF3	IRF3	NNP
cord-301362-f3lp10lm	61	1	(	(	-LRB-
cord-301362-f3lp10lm	61	2	interferon	interferon	NN
cord-301362-f3lp10lm	61	3	regulatory	regulatory	JJ
cord-301362-f3lp10lm	61	4	transcription	transcription	NN
cord-301362-f3lp10lm	61	5	factor	factor	NN
cord-301362-f3lp10lm	61	6	3	3	CD
cord-301362-f3lp10lm	61	7	)	)	-RRB-
cord-301362-f3lp10lm	61	8	,	,	,
cord-301362-f3lp10lm	61	9	NF	NF	NNP
cord-301362-f3lp10lm	61	10	-	-	HYPH
cord-301362-f3lp10lm	61	11	κβ	κβ	NNP
cord-301362-f3lp10lm	61	12	(	(	-LRB-
cord-301362-f3lp10lm	61	13	nuclear	nuclear	JJ
cord-301362-f3lp10lm	61	14	factor	factor	NN
cord-301362-f3lp10lm	61	15	-	-	HYPH
cord-301362-f3lp10lm	61	16	κβ	κβ	NN
cord-301362-f3lp10lm	61	17	)	)	-RRB-
cord-301362-f3lp10lm	61	18	and	and	CC
cord-301362-f3lp10lm	62	1	AP-1	AP-1	NNP
cord-301362-f3lp10lm	63	1	(	(	-LRB-
cord-301362-f3lp10lm	63	2	activator	activator	NN
cord-301362-f3lp10lm	63	3	protein	protein	NN
cord-301362-f3lp10lm	63	4	1	1	CD
cord-301362-f3lp10lm	63	5	)	)	-RRB-
cord-301362-f3lp10lm	63	6	thought	think	VBD
cord-301362-f3lp10lm	63	7	two	two	CD
cord-301362-f3lp10lm	63	8	different	different	JJ
cord-301362-f3lp10lm	63	9	branches	branch	NNS
cord-301362-f3lp10lm	63	10	(	(	-LRB-
cord-301362-f3lp10lm	63	11	Alexopoulou	Alexopoulou	NNP
cord-301362-f3lp10lm	63	12	et	et	NNP
cord-301362-f3lp10lm	63	13	al	al	NNP
cord-301362-f3lp10lm	63	14	.	.	NNP
cord-301362-f3lp10lm	63	15	,	,	,
cord-301362-f3lp10lm	63	16	2001	2001	CD
cord-301362-f3lp10lm	63	17	;	;	:
cord-301362-f3lp10lm	63	18	Sato	Sato	NNP
cord-301362-f3lp10lm	63	19	et	et	FW
cord-301362-f3lp10lm	63	20	al	al	NNP
cord-301362-f3lp10lm	63	21	.	.	NNP
cord-301362-f3lp10lm	63	22	,	,	,
cord-301362-f3lp10lm	63	23	2003	2003	CD
cord-301362-f3lp10lm	63	24	)	)	-RRB-
cord-301362-f3lp10lm	63	25	,	,	,
cord-301362-f3lp10lm	63	26	which	which	WDT
cord-301362-f3lp10lm	63	27	finally	finally	RB
cord-301362-f3lp10lm	63	28	generates	generate	VBZ
cord-301362-f3lp10lm	63	29	three	three	CD
cord-301362-f3lp10lm	63	30	major	major	JJ
cord-301362-f3lp10lm	63	31	antivirals	antiviral	NNS
cord-301362-f3lp10lm	63	32	responses	response	NNS
cord-301362-f3lp10lm	63	33	:	:	:
cord-301362-f3lp10lm	63	34	(	(	-LRB-
cord-301362-f3lp10lm	63	35	i	i	NN
cord-301362-f3lp10lm	63	36	)	)	-RRB-
cord-301362-f3lp10lm	63	37	type	type	NN
cord-301362-f3lp10lm	64	1	I	-PRON-	PRP
cord-301362-f3lp10lm	65	1	interferon	interferon	NN
cord-301362-f3lp10lm	65	2	production	production	NN
cord-301362-f3lp10lm	65	3	(	(	-LRB-
cord-301362-f3lp10lm	65	4	INF	INF	NNP
cord-301362-f3lp10lm	65	5	-	-	HYPH
cord-301362-f3lp10lm	65	6	α	α	NNP
cord-301362-f3lp10lm	65	7	/	/	SYM
cord-301362-f3lp10lm	65	8	β	β	NN
cord-301362-f3lp10lm	65	9	)	)	-RRB-
cord-301362-f3lp10lm	65	10	;	;	:
cord-301362-f3lp10lm	65	11	(	(	-LRB-
cord-301362-f3lp10lm	65	12	ii	ii	NN
cord-301362-f3lp10lm	65	13	)	)	-RRB-
cord-301362-f3lp10lm	65	14	cytopathic	cytopathic	JJ
cord-301362-f3lp10lm	65	15	effect	effect	NN
cord-301362-f3lp10lm	65	16	or	or	CC
cord-301362-f3lp10lm	65	17	infected	infect	VBN
cord-301362-f3lp10lm	65	18	-	-	HYPH
cord-301362-f3lp10lm	65	19	cell	cell	NN
cord-301362-f3lp10lm	65	20	death	death	NN
cord-301362-f3lp10lm	65	21	;	;	:
cord-301362-f3lp10lm	65	22	and	and	CC
cord-301362-f3lp10lm	65	23	(	(	-LRB-
cord-301362-f3lp10lm	65	24	iii	iii	NN
cord-301362-f3lp10lm	65	25	)	)	-RRB-
cord-301362-f3lp10lm	65	26	generation	generation	NN
cord-301362-f3lp10lm	65	27	of	of	IN
cord-301362-f3lp10lm	65	28	pro	pro	JJ
cord-301362-f3lp10lm	65	29	-	-	JJ
cord-301362-f3lp10lm	65	30	inflammatory	inflammatory	JJ
cord-301362-f3lp10lm	65	31	environment	environment	NN
cord-301362-f3lp10lm	65	32	by	by	IN
cord-301362-f3lp10lm	65	33	the	the	DT
cord-301362-f3lp10lm	65	34	activation	activation	NN
cord-301362-f3lp10lm	65	35	of	of	IN
cord-301362-f3lp10lm	65	36	NF	nf	NN
cord-301362-f3lp10lm	65	37	-	-	HYPH
cord-301362-f3lp10lm	65	38	κβ	κβ	NN
cord-301362-f3lp10lm	65	39	and	and	CC
cord-301362-f3lp10lm	65	40	AP-1	AP-1	NNP
cord-301362-f3lp10lm	65	41	.	.	.
cord-301362-f3lp10lm	66	1	During	during	IN
cord-301362-f3lp10lm	66	2	co	co	NN
cord-301362-f3lp10lm	66	3	-	-	NN
cord-301362-f3lp10lm	66	4	evolution	evolution	NN
cord-301362-f3lp10lm	66	5	with	with	IN
cord-301362-f3lp10lm	66	6	the	the	DT
cord-301362-f3lp10lm	66	7	cell	cell	NN
cord-301362-f3lp10lm	66	8	host	host	NN
cord-301362-f3lp10lm	66	9	,	,	,
cord-301362-f3lp10lm	66	10	viruses	virus	NNS
cord-301362-f3lp10lm	66	11	have	have	VBP
cord-301362-f3lp10lm	66	12	evolved	evolve	VBN
cord-301362-f3lp10lm	66	13	mechanisms	mechanism	NNS
cord-301362-f3lp10lm	66	14	to	to	TO
cord-301362-f3lp10lm	66	15	avoid	avoid	VB
cord-301362-f3lp10lm	66	16	cell	cell	NN
cord-301362-f3lp10lm	66	17	responses	response	NNS
cord-301362-f3lp10lm	66	18	against	against	IN
cord-301362-f3lp10lm	66	19	viral	viral	JJ
cord-301362-f3lp10lm	66	20	infections	infection	NNS
cord-301362-f3lp10lm	66	21	for	for	IN
cord-301362-f3lp10lm	66	22	their	-PRON-	PRP$
cord-301362-f3lp10lm	66	23	own	own	JJ
cord-301362-f3lp10lm	66	24	success	success	NN
cord-301362-f3lp10lm	66	25	.	.	.
cord-301362-f3lp10lm	67	1	Indeed	indeed	RB
cord-301362-f3lp10lm	67	2	,	,	,
cord-301362-f3lp10lm	67	3	hiding	hide	VBG
cord-301362-f3lp10lm	67	4	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	67	5	molecules	molecule	NNS
cord-301362-f3lp10lm	67	6	represents	represent	VBZ
cord-301362-f3lp10lm	67	7	a	a	DT
cord-301362-f3lp10lm	67	8	powerful	powerful	JJ
cord-301362-f3lp10lm	67	9	tool	tool	NN
cord-301362-f3lp10lm	67	10	to	to	TO
cord-301362-f3lp10lm	67	11	avoid	avoid	VB
cord-301362-f3lp10lm	67	12	a	a	DT
cord-301362-f3lp10lm	67	13	harsh	harsh	JJ
cord-301362-f3lp10lm	67	14	cellular	cellular	JJ
cord-301362-f3lp10lm	67	15	war	war	NN
cord-301362-f3lp10lm	67	16	against	against	IN
cord-301362-f3lp10lm	67	17	viruses	virus	NNS
cord-301362-f3lp10lm	67	18	'	'	POS
cord-301362-f3lp10lm	67	19	replication	replication	NN
cord-301362-f3lp10lm	67	20	that	that	WDT
cord-301362-f3lp10lm	67	21	initiates	initiate	VBZ
cord-301362-f3lp10lm	67	22	after	after	IN
cord-301362-f3lp10lm	67	23	TLR3	TLR3	NNP
cord-301362-f3lp10lm	67	24	recognition	recognition	NN
cord-301362-f3lp10lm	67	25	and	and	CC
cord-301362-f3lp10lm	67	26	activation	activation	NN
cord-301362-f3lp10lm	67	27	.	.	.
cord-301362-f3lp10lm	68	1	RIG	rig	NN
cord-301362-f3lp10lm	68	2	-	-	HYPH
cord-301362-f3lp10lm	68	3	I	i	NN
cord-301362-f3lp10lm	68	4	-	-	HYPH
cord-301362-f3lp10lm	68	5	like	like	JJ
cord-301362-f3lp10lm	68	6	receptors	receptor	NNS
cord-301362-f3lp10lm	68	7	(	(	-LRB-
cord-301362-f3lp10lm	68	8	RLRs	rlr	NNS
cord-301362-f3lp10lm	68	9	)	)	-RRB-
cord-301362-f3lp10lm	68	10	mainly	mainly	RB
cord-301362-f3lp10lm	68	11	include	include	VBP
cord-301362-f3lp10lm	68	12	the	the	DT
cord-301362-f3lp10lm	68	13	cytosolic	cytosolic	JJ
cord-301362-f3lp10lm	68	14	retinoic	retinoic	JJ
cord-301362-f3lp10lm	68	15	acid	acid	NN
cord-301362-f3lp10lm	68	16	-	-	HYPH
cord-301362-f3lp10lm	68	17	induced	induce	VBN
cord-301362-f3lp10lm	68	18	gene	gene	NN
cord-301362-f3lp10lm	68	19	I	i	NN
cord-301362-f3lp10lm	68	20	(	(	-LRB-
cord-301362-f3lp10lm	68	21	RIG	rig	NN
cord-301362-f3lp10lm	68	22	-	-	:
cord-301362-f3lp10lm	68	23	I	I	NNP
cord-301362-f3lp10lm	68	24	)	)	-RRB-
cord-301362-f3lp10lm	68	25	and	and	CC
cord-301362-f3lp10lm	68	26	the	the	DT
cord-301362-f3lp10lm	68	27	melanoma	melanoma	NN
cord-301362-f3lp10lm	68	28	differentiationassociated	differentiationassociate	VBD
cord-301362-f3lp10lm	68	29	gene	gene	NN
cord-301362-f3lp10lm	68	30	5	5	CD
cord-301362-f3lp10lm	68	31	(	(	-LRB-
cord-301362-f3lp10lm	68	32	MDA5	MDA5	NNP
cord-301362-f3lp10lm	68	33	)	)	-RRB-
cord-301362-f3lp10lm	68	34	,	,	,
cord-301362-f3lp10lm	68	35	both	both	DT
cord-301362-f3lp10lm	68	36	sharing	share	VBG
cord-301362-f3lp10lm	68	37	the	the	DT
cord-301362-f3lp10lm	68	38	same	same	JJ
cord-301362-f3lp10lm	68	39	molecular	molecular	JJ
cord-301362-f3lp10lm	68	40	architecture	architecture	NN
cord-301362-f3lp10lm	68	41	consisting	consist	VBG
cord-301362-f3lp10lm	68	42	in	in	IN
cord-301362-f3lp10lm	68	43	a	a	DT
cord-301362-f3lp10lm	68	44	conserved	conserved	JJ
cord-301362-f3lp10lm	68	45	"	"	``
cord-301362-f3lp10lm	68	46	helicase	helicase	NN
cord-301362-f3lp10lm	68	47	"	"	''
cord-301362-f3lp10lm	68	48	core	core	NN
cord-301362-f3lp10lm	68	49	connected	connect	VBN
cord-301362-f3lp10lm	68	50	to	to	IN
cord-301362-f3lp10lm	68	51	two	two	CD
cord-301362-f3lp10lm	68	52	caspase	caspase	NN
cord-301362-f3lp10lm	68	53	activation	activation	NN
cord-301362-f3lp10lm	68	54	and	and	CC
cord-301362-f3lp10lm	68	55	recruitment	recruitment	NN
cord-301362-f3lp10lm	68	56	domains	domain	NNS
cord-301362-f3lp10lm	68	57	(	(	-LRB-
cord-301362-f3lp10lm	68	58	CARDs	card	NNS
cord-301362-f3lp10lm	68	59	)	)	-RRB-
cord-301362-f3lp10lm	68	60	at	at	IN
cord-301362-f3lp10lm	68	61	the	the	DT
cord-301362-f3lp10lm	68	62	N	n	CD
cord-301362-f3lp10lm	68	63	-	-	HYPH
cord-301362-f3lp10lm	68	64	terminus	terminus	NN
cord-301362-f3lp10lm	68	65	,	,	,
cord-301362-f3lp10lm	68	66	and	and	CC
cord-301362-f3lp10lm	68	67	an	an	DT
cord-301362-f3lp10lm	68	68	RNA	RNA	NNP
cord-301362-f3lp10lm	68	69	binding	binding	NN
cord-301362-f3lp10lm	68	70	domain	domain	NN
cord-301362-f3lp10lm	68	71	known	know	VBN
cord-301362-f3lp10lm	68	72	as	as	IN
cord-301362-f3lp10lm	68	73	C	c	NN
cord-301362-f3lp10lm	68	74	-	-	HYPH
cord-301362-f3lp10lm	68	75	terminal	terminal	NN
cord-301362-f3lp10lm	68	76	domains	domain	NNS
cord-301362-f3lp10lm	68	77	(	(	-LRB-
cord-301362-f3lp10lm	68	78	CTD	CTD	NNP
cord-301362-f3lp10lm	68	79	)	)	-RRB-
cord-301362-f3lp10lm	68	80	(	(	-LRB-
cord-301362-f3lp10lm	68	81	Yoneyama	Yoneyama	NNP
cord-301362-f3lp10lm	68	82	et	et	NNP
cord-301362-f3lp10lm	68	83	al	al	NNP
cord-301362-f3lp10lm	68	84	.	.	NNP
cord-301362-f3lp10lm	68	85	,	,	,
cord-301362-f3lp10lm	68	86	2005	2005	CD
cord-301362-f3lp10lm	68	87	)	)	-RRB-
cord-301362-f3lp10lm	68	88	.	.	.
cord-301362-f3lp10lm	69	1	In	in	IN
cord-301362-f3lp10lm	69	2	the	the	DT
cord-301362-f3lp10lm	69	3	absence	absence	NN
cord-301362-f3lp10lm	69	4	of	of	IN
cord-301362-f3lp10lm	69	5	an	an	DT
cord-301362-f3lp10lm	69	6	RNA	RNA	NNP
cord-301362-f3lp10lm	69	7	trigger	trigger	NN
cord-301362-f3lp10lm	69	8	,	,	,
cord-301362-f3lp10lm	69	9	RIG	rig	NN
cord-301362-f3lp10lm	69	10	-	-	:
cord-301362-f3lp10lm	69	11	I	-PRON-	PRP
cord-301362-f3lp10lm	69	12	is	be	VBZ
cord-301362-f3lp10lm	69	13	in	in	IN
cord-301362-f3lp10lm	69	14	the	the	DT
cord-301362-f3lp10lm	69	15	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	69	16	in	in	IN
cord-301362-f3lp10lm	69	17	a	a	DT
cord-301362-f3lp10lm	69	18	resting	rest	VBG
cord-301362-f3lp10lm	69	19	state	state	NN
cord-301362-f3lp10lm	69	20	,	,	,
cord-301362-f3lp10lm	69	21	in	in	IN
cord-301362-f3lp10lm	69	22	which	which	WDT
cord-301362-f3lp10lm	69	23	the	the	DT
cord-301362-f3lp10lm	69	24	CARDs	card	NNS
cord-301362-f3lp10lm	69	25	fold	fold	VBP
cord-301362-f3lp10lm	69	26	back	back	RB
cord-301362-f3lp10lm	69	27	to	to	IN
cord-301362-f3lp10lm	69	28	the	the	DT
cord-301362-f3lp10lm	69	29	C	C	NNP
cord-301362-f3lp10lm	69	30	-	-	HYPH
cord-301362-f3lp10lm	69	31	terminal	terminal	NN
cord-301362-f3lp10lm	69	32	portion	portion	NN
cord-301362-f3lp10lm	69	33	.	.	.
cord-301362-f3lp10lm	70	1	Upon	upon	IN
cord-301362-f3lp10lm	70	2	binding	bind	VBG
cord-301362-f3lp10lm	70	3	of	of	IN
cord-301362-f3lp10lm	70	4	non	non	JJ
cord-301362-f3lp10lm	70	5	-	-	JJ
cord-301362-f3lp10lm	70	6	self	self	JJ
cord-301362-f3lp10lm	70	7	duplex	duplex	NN
cord-301362-f3lp10lm	70	8	RNA	RNA	NNP
cord-301362-f3lp10lm	70	9	,	,	,
cord-301362-f3lp10lm	70	10	RIG	rig	NN
cord-301362-f3lp10lm	70	11	-	-	:
cord-301362-f3lp10lm	70	12	I	-PRON-	PRP
cord-301362-f3lp10lm	70	13	hydrolyses	hydrolyse	VBZ
cord-301362-f3lp10lm	70	14	ATP	ATP	NNP
cord-301362-f3lp10lm	70	15	and	and	CC
cord-301362-f3lp10lm	70	16	undergoes	undergo	VBZ
cord-301362-f3lp10lm	70	17	extensive	extensive	JJ
cord-301362-f3lp10lm	70	18	structural	structural	JJ
cord-301362-f3lp10lm	70	19	rearrangements	rearrangement	NNS
cord-301362-f3lp10lm	70	20	to	to	TO
cord-301362-f3lp10lm	70	21	reach	reach	VB
cord-301362-f3lp10lm	70	22	the	the	DT
cord-301362-f3lp10lm	70	23	fully	fully	RB
cord-301362-f3lp10lm	70	24	activated	activate	VBN
cord-301362-f3lp10lm	70	25	state	state	NN
cord-301362-f3lp10lm	70	26	displaying	display	VBG
cord-301362-f3lp10lm	70	27	the	the	DT
cord-301362-f3lp10lm	70	28	N	n	CD
cord-301362-f3lp10lm	70	29	-	-	HYPH
cord-301362-f3lp10lm	70	30	terminal	terminal	NN
cord-301362-f3lp10lm	70	31	CARDs	card	NNS
cord-301362-f3lp10lm	70	32	and	and	CC
cord-301362-f3lp10lm	70	33	initiating	initiate	VBG
cord-301362-f3lp10lm	70	34	the	the	DT
cord-301362-f3lp10lm	70	35	antiviral	antiviral	JJ
cord-301362-f3lp10lm	70	36	signaling	signaling	NN
cord-301362-f3lp10lm	70	37	cascade	cascade	NN
cord-301362-f3lp10lm	70	38	(	(	-LRB-
cord-301362-f3lp10lm	70	39	Yoneyama	Yoneyama	NNP
cord-301362-f3lp10lm	70	40	et	et	NNP
cord-301362-f3lp10lm	70	41	al	al	NNP
cord-301362-f3lp10lm	70	42	.	.	NNP
cord-301362-f3lp10lm	70	43	,	,	,
cord-301362-f3lp10lm	70	44	2004	2004	CD
cord-301362-f3lp10lm	70	45	;	;	:
cord-301362-f3lp10lm	70	46	Fujita	Fujita	NNP
cord-301362-f3lp10lm	70	47	et	et	NNP
cord-301362-f3lp10lm	70	48	al	al	NNP
cord-301362-f3lp10lm	70	49	.	.	NNP
cord-301362-f3lp10lm	70	50	,	,	,
cord-301362-f3lp10lm	70	51	2007	2007	CD
cord-301362-f3lp10lm	70	52	;	;	:
cord-301362-f3lp10lm	70	53	Saito	Saito	NNP
cord-301362-f3lp10lm	70	54	et	et	FW
cord-301362-f3lp10lm	70	55	al	al	NNP
cord-301362-f3lp10lm	70	56	.	.	NNP
cord-301362-f3lp10lm	70	57	,	,	,
cord-301362-f3lp10lm	70	58	2007	2007	CD
cord-301362-f3lp10lm	70	59	)	)	-RRB-
cord-301362-f3lp10lm	70	60	.	.	.
cord-301362-f3lp10lm	71	1	RNA	RNA	NNP
cord-301362-f3lp10lm	71	2	recognition	recognition	NN
cord-301362-f3lp10lm	71	3	by	by	IN
cord-301362-f3lp10lm	71	4	RIG	rig	NN
cord-301362-f3lp10lm	72	1	-I	-i	WP
cord-301362-f3lp10lm	72	2	involves	involve	VBZ
cord-301362-f3lp10lm	72	3	three	three	CD
cord-301362-f3lp10lm	72	4	different	different	JJ
cord-301362-f3lp10lm	72	5	RIG	rig	NN
cord-301362-f3lp10lm	72	6	-	-	HYPH
cord-301362-f3lp10lm	72	7	I	i	NN
cord-301362-f3lp10lm	72	8	domains	domain	NNS
cord-301362-f3lp10lm	72	9	(	(	-LRB-
cord-301362-f3lp10lm	72	10	HEL1	HEL1	NNP
cord-301362-f3lp10lm	72	11	,	,	,
cord-301362-f3lp10lm	72	12	HEL2i	HEL2i	NNP
cord-301362-f3lp10lm	72	13	,	,	,
cord-301362-f3lp10lm	72	14	and	and	CC
cord-301362-f3lp10lm	72	15	the	the	DT
cord-301362-f3lp10lm	72	16	CTD	CTD	NNP
cord-301362-f3lp10lm	72	17	)	)	-RRB-
cord-301362-f3lp10lm	72	18	that	that	IN
cord-301362-f3lp10lm	72	19	together	together	RB
cord-301362-f3lp10lm	72	20	clasp	clasp	VBP
cord-301362-f3lp10lm	72	21	the	the	DT
cord-301362-f3lp10lm	72	22	duplex	duplex	NN
cord-301362-f3lp10lm	72	23	RNA	RNA	NNP
cord-301362-f3lp10lm	72	24	,	,	,
cord-301362-f3lp10lm	72	25	enwrapping	enwrap	VBG
cord-301362-f3lp10lm	72	26	it	-PRON-	PRP
cord-301362-f3lp10lm	72	27	within	within	IN
cord-301362-f3lp10lm	72	28	a	a	DT
cord-301362-f3lp10lm	72	29	network	network	NN
cord-301362-f3lp10lm	72	30	of	of	IN
cord-301362-f3lp10lm	72	31	interactions	interaction	NNS
cord-301362-f3lp10lm	72	32	that	that	WDT
cord-301362-f3lp10lm	72	33	are	be	VBP
cord-301362-f3lp10lm	72	34	dominated	dominate	VBN
cord-301362-f3lp10lm	72	35	by	by	IN
cord-301362-f3lp10lm	72	36	polar	polar	JJ
cord-301362-f3lp10lm	72	37	contacts	contact	NNS
cord-301362-f3lp10lm	72	38	(	(	-LRB-
cord-301362-f3lp10lm	72	39	Luo	Luo	NNP
cord-301362-f3lp10lm	72	40	et	et	NNP
cord-301362-f3lp10lm	72	41	al	al	NNP
cord-301362-f3lp10lm	72	42	.	.	NNP
cord-301362-f3lp10lm	72	43	,	,	,
cord-301362-f3lp10lm	72	44	2011	2011	CD
cord-301362-f3lp10lm	72	45	)	)	-RRB-
cord-301362-f3lp10lm	72	46	.	.	.
cord-301362-f3lp10lm	73	1	Accurately	accurately	RB
cord-301362-f3lp10lm	73	2	defining	define	VBG
cord-301362-f3lp10lm	73	3	the	the	DT
cord-301362-f3lp10lm	73	4	RIG	rig	NN
cord-301362-f3lp10lm	73	5	-	-	:
cord-301362-f3lp10lm	73	6	I	I	NNP
cord-301362-f3lp10lm	73	7	stimulatory	stimulatory	JJ
cord-301362-f3lp10lm	73	8	RNA	RNA	NNP
cord-301362-f3lp10lm	73	9	structure	structure	NN
cord-301362-f3lp10lm	73	10	and	and	CC
cord-301362-f3lp10lm	73	11	sequence	sequence	NN
cord-301362-f3lp10lm	73	12	remains	remain	VBZ
cord-301362-f3lp10lm	73	13	controversial	controversial	JJ
cord-301362-f3lp10lm	73	14	.	.	.
cord-301362-f3lp10lm	74	1	However	however	RB
cord-301362-f3lp10lm	74	2	,	,	,
cord-301362-f3lp10lm	74	3	it	-PRON-	PRP
cord-301362-f3lp10lm	74	4	seems	seem	VBZ
cord-301362-f3lp10lm	74	5	clear	clear	JJ
cord-301362-f3lp10lm	74	6	that	that	IN
cord-301362-f3lp10lm	74	7	short	short	JJ
cord-301362-f3lp10lm	74	8	(	(	-LRB-
cord-301362-f3lp10lm	74	9	<	<	NNP
cord-301362-f3lp10lm	74	10	300	300	CD
cord-301362-f3lp10lm	74	11	bp	bp	NNP
cord-301362-f3lp10lm	74	12	)	)	-RRB-
cord-301362-f3lp10lm	74	13	dsRNA	dsRNA	.
cord-301362-f3lp10lm	75	1	panhandle	panhandle	NNP
cord-301362-f3lp10lm	75	2	structures	structure	NNS
cord-301362-f3lp10lm	75	3	are	be	VBP
cord-301362-f3lp10lm	75	4	stimulatory	stimulatory	JJ
cord-301362-f3lp10lm	75	5	if	if	IN
cord-301362-f3lp10lm	75	6	they	-PRON-	PRP
cord-301362-f3lp10lm	75	7	contain	contain	VBP
cord-301362-f3lp10lm	75	8	exposed	expose	VBN
cord-301362-f3lp10lm	76	1	5	5	LS
cord-301362-f3lp10lm	76	2	′	′	CD
cord-301362-f3lp10lm	76	3	-triphosphate	-triphosphate	.
cord-301362-f3lp10lm	77	1	(	(	-LRB-
cord-301362-f3lp10lm	77	2	5	5	CD
cord-301362-f3lp10lm	77	3	′	′	CD
cord-301362-f3lp10lm	77	4	-ppp	-ppp	:
cord-301362-f3lp10lm	77	5	)	)	-RRB-
cord-301362-f3lp10lm	77	6	and	and	CC
cord-301362-f3lp10lm	77	7	blunted	blunt	VBN
cord-301362-f3lp10lm	77	8	5	5	CD
cord-301362-f3lp10lm	77	9	′	′	CD
cord-301362-f3lp10lm	77	10	end	end	NN
cord-301362-f3lp10lm	78	1	(	(	-LRB-
cord-301362-f3lp10lm	78	2	Hornung	Hornung	NNP
cord-301362-f3lp10lm	78	3	et	et	NNP
cord-301362-f3lp10lm	78	4	al	al	NNP
cord-301362-f3lp10lm	78	5	.	.	NNP
cord-301362-f3lp10lm	78	6	,	,	,
cord-301362-f3lp10lm	78	7	2006	2006	CD
cord-301362-f3lp10lm	78	8	;	;	.
cord-301362-f3lp10lm	79	1	Kato	Kato	NNP
cord-301362-f3lp10lm	79	2	et	et	NNP
cord-301362-f3lp10lm	79	3	al	al	NNP
cord-301362-f3lp10lm	79	4	.	.	NNP
cord-301362-f3lp10lm	79	5	,	,	,
cord-301362-f3lp10lm	79	6	2006	2006	CD
cord-301362-f3lp10lm	79	7	;	;	:
cord-301362-f3lp10lm	79	8	Pichlmair	Pichlmair	NNP
cord-301362-f3lp10lm	79	9	et	et	NNP
cord-301362-f3lp10lm	79	10	al	al	NNP
cord-301362-f3lp10lm	79	11	.	.	NNP
cord-301362-f3lp10lm	79	12	,	,	,
cord-301362-f3lp10lm	79	13	2006	2006	CD
cord-301362-f3lp10lm	80	1	;	;	:
cord-301362-f3lp10lm	80	2	Marq	Marq	NNP
cord-301362-f3lp10lm	80	3	et	et	NNP
cord-301362-f3lp10lm	80	4	al	al	NNP
cord-301362-f3lp10lm	80	5	.	.	NNP
cord-301362-f3lp10lm	80	6	,	,	,
cord-301362-f3lp10lm	80	7	2011	2011	CD
cord-301362-f3lp10lm	80	8	)	)	-RRB-
cord-301362-f3lp10lm	80	9	.	.	.
cord-301362-f3lp10lm	81	1	An	an	DT
cord-301362-f3lp10lm	81	2	overview	overview	NN
cord-301362-f3lp10lm	81	3	of	of	IN
cord-301362-f3lp10lm	81	4	RIG	rig	NN
cord-301362-f3lp10lm	81	5	-	-	:
cord-301362-f3lp10lm	81	6	I	-PRON-	PRP
cord-301362-f3lp10lm	81	7	interaction	interaction	NN
cord-301362-f3lp10lm	81	8	with	with	IN
cord-301362-f3lp10lm	81	9	viruses	virus	NNS
cord-301362-f3lp10lm	81	10	from	from	IN
cord-301362-f3lp10lm	81	11	different	different	JJ
cord-301362-f3lp10lm	81	12	genera	genus	NNS
cord-301362-f3lp10lm	81	13	has	have	VBZ
cord-301362-f3lp10lm	81	14	been	be	VBN
cord-301362-f3lp10lm	81	15	recently	recently	RB
cord-301362-f3lp10lm	81	16	reviewed	review	VBN
cord-301362-f3lp10lm	81	17	by	by	IN
cord-301362-f3lp10lm	81	18	Kell	Kell	NNP
cord-301362-f3lp10lm	81	19	and	and	CC
cord-301362-f3lp10lm	81	20	Gale	Gale	NNP
cord-301362-f3lp10lm	81	21	(	(	-LRB-
cord-301362-f3lp10lm	81	22	2015	2015	CD
cord-301362-f3lp10lm	81	23	)	)	-RRB-
cord-301362-f3lp10lm	81	24	.	.	.
cord-301362-f3lp10lm	82	1	On	on	IN
cord-301362-f3lp10lm	82	2	the	the	DT
cord-301362-f3lp10lm	82	3	other	other	JJ
cord-301362-f3lp10lm	82	4	hand	hand	NN
cord-301362-f3lp10lm	82	5	,	,	,
cord-301362-f3lp10lm	82	6	MDA5	MDA5	NNP
cord-301362-f3lp10lm	82	7	binds	bind	VBZ
cord-301362-f3lp10lm	82	8	to	to	IN
cord-301362-f3lp10lm	82	9	long	long	RB
cord-301362-f3lp10lm	82	10	dsRNA	dsRNA	.
cord-301362-f3lp10lm	83	1	(	(	-LRB-
cord-301362-f3lp10lm	83	2	>	>	NFP
cord-301362-f3lp10lm	83	3	1000	1000	CD
cord-301362-f3lp10lm	83	4	bp	bp	NNP
cord-301362-f3lp10lm	83	5	)	)	-RRB-
cord-301362-f3lp10lm	83	6	with	with	IN
cord-301362-f3lp10lm	83	7	no	no	DT
cord-301362-f3lp10lm	83	8	end	end	NN
cord-301362-f3lp10lm	83	9	specificity	specificity	NN
cord-301362-f3lp10lm	83	10	(	(	-LRB-
cord-301362-f3lp10lm	83	11	Hornung	Hornung	NNP
cord-301362-f3lp10lm	83	12	et	et	NNP
cord-301362-f3lp10lm	83	13	al	al	NNP
cord-301362-f3lp10lm	83	14	.	.	NNP
cord-301362-f3lp10lm	83	15	,	,	,
cord-301362-f3lp10lm	83	16	2006	2006	CD
cord-301362-f3lp10lm	84	1	;	;	:
cord-301362-f3lp10lm	84	2	Kato	Kato	NNP
cord-301362-f3lp10lm	84	3	et	et	NNP
cord-301362-f3lp10lm	84	4	al	al	NNP
cord-301362-f3lp10lm	84	5	.	.	NNP
cord-301362-f3lp10lm	84	6	,	,	,
cord-301362-f3lp10lm	84	7	2006	2006	CD
cord-301362-f3lp10lm	84	8	;	;	:
cord-301362-f3lp10lm	84	9	Pichlmair	Pichlmair	NNP
cord-301362-f3lp10lm	84	10	et	et	NNP
cord-301362-f3lp10lm	84	11	al	al	NNP
cord-301362-f3lp10lm	84	12	.	.	NNP
cord-301362-f3lp10lm	84	13	,	,	,
cord-301362-f3lp10lm	84	14	2006	2006	CD
cord-301362-f3lp10lm	84	15	)	)	-RRB-
cord-301362-f3lp10lm	84	16	and	and	CC
cord-301362-f3lp10lm	84	17	by	by	IN
cord-301362-f3lp10lm	84	18	a	a	DT
cord-301362-f3lp10lm	84	19	different	different	JJ
cord-301362-f3lp10lm	84	20	mechanism	mechanism	NN
cord-301362-f3lp10lm	84	21	,	,	,
cord-301362-f3lp10lm	84	22	which	which	WDT
cord-301362-f3lp10lm	84	23	leads	lead	VBZ
cord-301362-f3lp10lm	84	24	MDA5	MDA5	NNP
cord-301362-f3lp10lm	84	25	to	to	TO
cord-301362-f3lp10lm	84	26	form	form	VB
cord-301362-f3lp10lm	84	27	a	a	DT
cord-301362-f3lp10lm	84	28	filament	filament	NN
cord-301362-f3lp10lm	84	29	along	along	IN
cord-301362-f3lp10lm	84	30	dsRNA	dsrna	NN
cord-301362-f3lp10lm	84	31	,	,	,
cord-301362-f3lp10lm	84	32	initiated	initiate	VBN
cord-301362-f3lp10lm	84	33	from	from	IN
cord-301362-f3lp10lm	84	34	internal	internal	JJ
cord-301362-f3lp10lm	84	35	sites	site	NNS
cord-301362-f3lp10lm	84	36	in	in	IN
cord-301362-f3lp10lm	84	37	the	the	DT
cord-301362-f3lp10lm	84	38	dsRNA	dsrna	NN
cord-301362-f3lp10lm	84	39	rather	rather	RB
cord-301362-f3lp10lm	84	40	than	than	IN
cord-301362-f3lp10lm	84	41	from	from	IN
cord-301362-f3lp10lm	84	42	the	the	DT
cord-301362-f3lp10lm	84	43	ends	end	NNS
cord-301362-f3lp10lm	84	44	(	(	-LRB-
cord-301362-f3lp10lm	84	45	Peisley	Peisley	NNP
cord-301362-f3lp10lm	84	46	et	et	NNP
cord-301362-f3lp10lm	84	47	al	al	NNP
cord-301362-f3lp10lm	84	48	.	.	NNP
cord-301362-f3lp10lm	84	49	,	,	,
cord-301362-f3lp10lm	84	50	2011	2011	CD
cord-301362-f3lp10lm	85	1	(	(	-LRB-
cord-301362-f3lp10lm	85	2	Peisley	Peisley	NNP
cord-301362-f3lp10lm	85	3	et	et	NNP
cord-301362-f3lp10lm	85	4	al	al	NNP
cord-301362-f3lp10lm	85	5	.	.	.
cord-301362-f3lp10lm	86	1	,	,	,
cord-301362-f3lp10lm	87	1	,	,	,
cord-301362-f3lp10lm	87	2	2013	2013	CD
cord-301362-f3lp10lm	87	3	Berke	Berke	NNP
cord-301362-f3lp10lm	87	4	and	and	CC
cord-301362-f3lp10lm	87	5	Modis	Modis	NNP
cord-301362-f3lp10lm	87	6	,	,	,
cord-301362-f3lp10lm	87	7	2012	2012	CD
cord-301362-f3lp10lm	87	8	)	)	-RRB-
cord-301362-f3lp10lm	87	9	.	.	.
cord-301362-f3lp10lm	88	1	Both	both	DT
cord-301362-f3lp10lm	88	2	RLRs	rlr	NNS
cord-301362-f3lp10lm	88	3	form	form	VBP
cord-301362-f3lp10lm	88	4	large	large	JJ
cord-301362-f3lp10lm	88	5	oligomeric	oligomeric	JJ
cord-301362-f3lp10lm	88	6	structures	structure	NNS
cord-301362-f3lp10lm	88	7	around	around	IN
cord-301362-f3lp10lm	88	8	dsRNA	dsrna	NN
cord-301362-f3lp10lm	88	9	molecules	molecule	NNS
cord-301362-f3lp10lm	88	10	that	that	WDT
cord-301362-f3lp10lm	88	11	serve	serve	VBP
cord-301362-f3lp10lm	88	12	as	as	IN
cord-301362-f3lp10lm	88	13	platforms	platform	NNS
cord-301362-f3lp10lm	88	14	for	for	IN
cord-301362-f3lp10lm	88	15	recruitment	recruitment	NN
cord-301362-f3lp10lm	88	16	and	and	CC
cord-301362-f3lp10lm	88	17	nucleation	nucleation	NN
cord-301362-f3lp10lm	88	18	of	of	IN
cord-301362-f3lp10lm	88	19	mitochondrial	mitochondrial	JJ
cord-301362-f3lp10lm	88	20	antiviral	antiviral	JJ
cord-301362-f3lp10lm	88	21	signaling	signal	VBG
cord-301362-f3lp10lm	88	22	protein	protein	NN
cord-301362-f3lp10lm	88	23	(	(	-LRB-
cord-301362-f3lp10lm	88	24	MAVS	MAVS	NNP
cord-301362-f3lp10lm	88	25	)	)	-RRB-
cord-301362-f3lp10lm	89	1	(	(	-LRB-
cord-301362-f3lp10lm	89	2	Peisley	Peisley	NNP
cord-301362-f3lp10lm	89	3	et	et	NNP
cord-301362-f3lp10lm	89	4	al	al	NNP
cord-301362-f3lp10lm	89	5	.	.	NNP
cord-301362-f3lp10lm	89	6	,	,	,
cord-301362-f3lp10lm	89	7	2013	2013	CD
cord-301362-f3lp10lm	89	8	;	;	:
cord-301362-f3lp10lm	89	9	Xu	Xu	NNP
cord-301362-f3lp10lm	89	10	et	et	NNP
cord-301362-f3lp10lm	89	11	al	al	NNP
cord-301362-f3lp10lm	89	12	.	.	NNP
cord-301362-f3lp10lm	89	13	,	,	,
cord-301362-f3lp10lm	89	14	2014	2014	CD
cord-301362-f3lp10lm	89	15	)	)	-RRB-
cord-301362-f3lp10lm	89	16	.	.	.
cord-301362-f3lp10lm	90	1	MAVS	MAVS	NNP
cord-301362-f3lp10lm	90	2	form	form	VBP
cord-301362-f3lp10lm	90	3	a	a	DT
cord-301362-f3lp10lm	90	4	polymeric	polymeric	JJ
cord-301362-f3lp10lm	90	5	structure	structure	NN
cord-301362-f3lp10lm	90	6	as	as	RB
cord-301362-f3lp10lm	90	7	well	well	RB
cord-301362-f3lp10lm	90	8	,	,	,
cord-301362-f3lp10lm	90	9	self	self	NN
cord-301362-f3lp10lm	90	10	-	-	HYPH
cord-301362-f3lp10lm	90	11	propagating	propagate	VBG
cord-301362-f3lp10lm	90	12	drawing	draw	VBG
cord-301362-f3lp10lm	90	13	soluble	soluble	JJ
cord-301362-f3lp10lm	90	14	monomers	monomer	NNS
cord-301362-f3lp10lm	90	15	from	from	IN
cord-301362-f3lp10lm	90	16	the	the	DT
cord-301362-f3lp10lm	90	17	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	90	18	into	into	IN
cord-301362-f3lp10lm	90	19	the	the	DT
cord-301362-f3lp10lm	90	20	growing	grow	VBG
cord-301362-f3lp10lm	90	21	polymer	polymer	NN
cord-301362-f3lp10lm	91	1	(	(	-LRB-
cord-301362-f3lp10lm	91	2	Hou	Hou	NNP
cord-301362-f3lp10lm	91	3	et	et	FW
cord-301362-f3lp10lm	91	4	al	al	NNP
cord-301362-f3lp10lm	91	5	.	.	.
cord-301362-f3lp10lm	92	1	,	,	,
cord-301362-f3lp10lm	92	2	2011	2011	CD
cord-301362-f3lp10lm	92	3	)	)	-RRB-
cord-301362-f3lp10lm	92	4	.	.	.
cord-301362-f3lp10lm	93	1	The	the	DT
cord-301362-f3lp10lm	93	2	polymeric	polymeric	JJ
cord-301362-f3lp10lm	93	3	form	form	NN
cord-301362-f3lp10lm	93	4	of	of	IN
cord-301362-f3lp10lm	93	5	MAVS	MAVS	NNPS
cord-301362-f3lp10lm	93	6	is	be	VBZ
cord-301362-f3lp10lm	93	7	tethered	tether	VBN
cord-301362-f3lp10lm	93	8	to	to	IN
cord-301362-f3lp10lm	93	9	the	the	DT
cord-301362-f3lp10lm	93	10	mitochondrial	mitochondrial	JJ
cord-301362-f3lp10lm	93	11	membrane	membrane	NN
cord-301362-f3lp10lm	93	12	where	where	WRB
cord-301362-f3lp10lm	93	13	it	-PRON-	PRP
cord-301362-f3lp10lm	93	14	triggers	trigger	VBZ
cord-301362-f3lp10lm	93	15	the	the	DT
cord-301362-f3lp10lm	93	16	activation	activation	NN
cord-301362-f3lp10lm	93	17	of	of	IN
cord-301362-f3lp10lm	93	18	the	the	DT
cord-301362-f3lp10lm	93	19	cytosolic	cytosolic	JJ
cord-301362-f3lp10lm	93	20	kinases	kinase	NNS
cord-301362-f3lp10lm	93	21	IkB	IkB	NNP
cord-301362-f3lp10lm	93	22	-	-	HYPH
cord-301362-f3lp10lm	93	23	ε	ε	NNP
cord-301362-f3lp10lm	93	24	(	(	-LRB-
cord-301362-f3lp10lm	93	25	IKKε	IKKε	NNP
cord-301362-f3lp10lm	93	26	)	)	-RRB-
cord-301362-f3lp10lm	93	27	and	and	CC
cord-301362-f3lp10lm	93	28	Tank	tank	NN
cord-301362-f3lp10lm	93	29	-	-	HYPH
cord-301362-f3lp10lm	93	30	binding	bind	VBG
cord-301362-f3lp10lm	93	31	kinase	kinase	NN
cord-301362-f3lp10lm	93	32	-	-	:
cord-301362-f3lp10lm	93	33	I	i	NN
cord-301362-f3lp10lm	93	34	(	(	-LRB-
cord-301362-f3lp10lm	93	35	TBKI	TBKI	NNP
cord-301362-f3lp10lm	93	36	)	)	-RRB-
cord-301362-f3lp10lm	93	37	,	,	,
cord-301362-f3lp10lm	93	38	which	which	WDT
cord-301362-f3lp10lm	93	39	in	in	IN
cord-301362-f3lp10lm	93	40	turn	turn	NN
cord-301362-f3lp10lm	93	41	activate	activate	VBP
cord-301362-f3lp10lm	93	42	NF	nf	NN
cord-301362-f3lp10lm	93	43	-	-	HYPH
cord-301362-f3lp10lm	93	44	κβ	κβ	NNP
cord-301362-f3lp10lm	93	45	and	and	CC
cord-301362-f3lp10lm	93	46	IRF3	IRF3	NNP
cord-301362-f3lp10lm	93	47	,	,	,
cord-301362-f3lp10lm	93	48	respectively	respectively	RB
cord-301362-f3lp10lm	94	1	(	(	-LRB-
cord-301362-f3lp10lm	94	2	Fitzgerald	Fitzgerald	NNP
cord-301362-f3lp10lm	94	3	et	et	NNP
cord-301362-f3lp10lm	94	4	al	al	NNP
cord-301362-f3lp10lm	94	5	.	.	NNP
cord-301362-f3lp10lm	94	6	,	,	,
cord-301362-f3lp10lm	94	7	2003	2003	CD
cord-301362-f3lp10lm	94	8	;	;	:
cord-301362-f3lp10lm	95	1	Yoneyama	Yoneyama	NNP
cord-301362-f3lp10lm	95	2	et	et	NNP
cord-301362-f3lp10lm	95	3	al	al	NNP
cord-301362-f3lp10lm	95	4	.	.	NNP
cord-301362-f3lp10lm	95	5	,	,	,
cord-301362-f3lp10lm	95	6	2004	2004	CD
cord-301362-f3lp10lm	95	7	)	)	-RRB-
cord-301362-f3lp10lm	95	8	.	.	.
cord-301362-f3lp10lm	96	1	Activated	activate	VBN
cord-301362-f3lp10lm	96	2	NFκβ	NFκβ	NNP
cord-301362-f3lp10lm	96	3	and	and	CC
cord-301362-f3lp10lm	96	4	IRF3	IRF3	NNP
cord-301362-f3lp10lm	96	5	are	be	VBP
cord-301362-f3lp10lm	96	6	translocated	translocate	VBN
cord-301362-f3lp10lm	96	7	into	into	IN
cord-301362-f3lp10lm	96	8	the	the	DT
cord-301362-f3lp10lm	96	9	nucleus	nucleus	NN
cord-301362-f3lp10lm	96	10	where	where	WRB
cord-301362-f3lp10lm	96	11	they	-PRON-	PRP
cord-301362-f3lp10lm	96	12	induce	induce	VBP
cord-301362-f3lp10lm	96	13	expression	expression	NN
cord-301362-f3lp10lm	96	14	of	of	IN
cord-301362-f3lp10lm	96	15	type	type	NN
cord-301362-f3lp10lm	97	1	I	-PRON-	PRP
cord-301362-f3lp10lm	97	2	interferon	interferon	VBD
cord-301362-f3lp10lm	97	3	and	and	CC
cord-301362-f3lp10lm	97	4	other	other	JJ
cord-301362-f3lp10lm	97	5	inflammatory	inflammatory	JJ
cord-301362-f3lp10lm	97	6	antimicrobial	antimicrobial	JJ
cord-301362-f3lp10lm	97	7	molecules	molecule	NNS
cord-301362-f3lp10lm	97	8	.	.	.
cord-301362-f3lp10lm	98	1	Viruses	virus	NNS
cord-301362-f3lp10lm	98	2	replicate	replicate	VBP
cord-301362-f3lp10lm	98	3	in	in	IN
cord-301362-f3lp10lm	98	4	the	the	DT
cord-301362-f3lp10lm	98	5	host	host	NN
cord-301362-f3lp10lm	98	6	cell	cell	NN
cord-301362-f3lp10lm	98	7	to	to	TO
cord-301362-f3lp10lm	98	8	generate	generate	VB
cord-301362-f3lp10lm	98	9	new	new	JJ
cord-301362-f3lp10lm	98	10	infectious	infectious	JJ
cord-301362-f3lp10lm	98	11	virions	virion	NNS
cord-301362-f3lp10lm	98	12	.	.	.
cord-301362-f3lp10lm	99	1	To	to	TO
cord-301362-f3lp10lm	99	2	overcome	overcome	VB
cord-301362-f3lp10lm	99	3	the	the	DT
cord-301362-f3lp10lm	99	4	innate	innate	JJ
cord-301362-f3lp10lm	99	5	antiviral	antiviral	JJ
cord-301362-f3lp10lm	99	6	response	response	NN
cord-301362-f3lp10lm	99	7	,	,	,
cord-301362-f3lp10lm	99	8	viral	viral	JJ
cord-301362-f3lp10lm	99	9	particles	particle	NNS
cord-301362-f3lp10lm	99	10	include	include	VBP
cord-301362-f3lp10lm	99	11	ways	way	NNS
cord-301362-f3lp10lm	99	12	to	to	TO
cord-301362-f3lp10lm	99	13	circumvent	circumvent	VB
cord-301362-f3lp10lm	99	14	INF	inf	NN
cord-301362-f3lp10lm	99	15	-	-	HYPH
cord-301362-f3lp10lm	99	16	α	α	NNP
cord-301362-f3lp10lm	99	17	/	/	SYM
cord-301362-f3lp10lm	99	18	β	β	NN
cord-301362-f3lp10lm	99	19	production	production	NN
cord-301362-f3lp10lm	99	20	achieved	achieve	VBN
cord-301362-f3lp10lm	99	21	by	by	IN
cord-301362-f3lp10lm	99	22	blocking	block	VBG
cord-301362-f3lp10lm	99	23	the	the	DT
cord-301362-f3lp10lm	99	24	RLR	RLR	NNP
cord-301362-f3lp10lm	99	25	pathway	pathway	NN
cord-301362-f3lp10lm	99	26	in	in	IN
cord-301362-f3lp10lm	99	27	its	-PRON-	PRP$
cord-301362-f3lp10lm	99	28	upstream	upstream	JJ
cord-301362-f3lp10lm	99	29	portion	portion	NN
cord-301362-f3lp10lm	99	30	to	to	TO
cord-301362-f3lp10lm	99	31	avoid	avoid	VB
cord-301362-f3lp10lm	99	32	dsRNA	dsrna	RB
cord-301362-f3lp10lm	99	33	-	-	HYPH
cord-301362-f3lp10lm	99	34	mediated	mediate	VBN
cord-301362-f3lp10lm	99	35	activation	activation	NN
cord-301362-f3lp10lm	99	36	of	of	IN
cord-301362-f3lp10lm	99	37	RLRs	rlr	NNS
cord-301362-f3lp10lm	99	38	,	,	,
cord-301362-f3lp10lm	99	39	further	further	RB
cord-301362-f3lp10lm	99	40	evidencing	evidence	VBG
cord-301362-f3lp10lm	99	41	the	the	DT
cord-301362-f3lp10lm	99	42	potency	potency	NN
cord-301362-f3lp10lm	99	43	of	of	IN
cord-301362-f3lp10lm	99	44	such	such	JJ
cord-301362-f3lp10lm	99	45	PAMP	PAMP	NNP
cord-301362-f3lp10lm	99	46	in	in	IN
cord-301362-f3lp10lm	99	47	triggering	trigger	VBG
cord-301362-f3lp10lm	99	48	a	a	DT
cord-301362-f3lp10lm	99	49	robust	robust	JJ
cord-301362-f3lp10lm	99	50	innate	innate	JJ
cord-301362-f3lp10lm	99	51	immune	immune	JJ
cord-301362-f3lp10lm	99	52	response	response	NN
cord-301362-f3lp10lm	99	53	(	(	-LRB-
cord-301362-f3lp10lm	99	54	Bowie	Bowie	NNP
cord-301362-f3lp10lm	99	55	and	and	CC
cord-301362-f3lp10lm	99	56	Unterholzner	Unterholzner	NNP
cord-301362-f3lp10lm	99	57	,	,	,
cord-301362-f3lp10lm	99	58	2008	2008	CD
cord-301362-f3lp10lm	99	59	)	)	-RRB-
cord-301362-f3lp10lm	99	60	.	.	.
cord-301362-f3lp10lm	100	1	Indeed	indeed	RB
cord-301362-f3lp10lm	100	2	,	,	,
cord-301362-f3lp10lm	100	3	hiding	hide	VBG
cord-301362-f3lp10lm	100	4	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	100	5	molecules	molecule	NNS
cord-301362-f3lp10lm	100	6	from	from	IN
cord-301362-f3lp10lm	100	7	RLRs	rlr	NNS
cord-301362-f3lp10lm	100	8	in	in	IN
cord-301362-f3lp10lm	100	9	compartmentalized	compartmentalize	VBN
cord-301362-f3lp10lm	100	10	microenvironments	microenvironment	NNS
cord-301362-f3lp10lm	100	11	inside	inside	IN
cord-301362-f3lp10lm	100	12	the	the	DT
cord-301362-f3lp10lm	100	13	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	100	14	comprise	comprise	VBP
cord-301362-f3lp10lm	100	15	a	a	DT
cord-301362-f3lp10lm	100	16	powerful	powerful	JJ
cord-301362-f3lp10lm	100	17	strategy	strategy	NN
cord-301362-f3lp10lm	100	18	to	to	TO
cord-301362-f3lp10lm	100	19	tackle	tackle	VB
cord-301362-f3lp10lm	100	20	RLRs	rlr	NNS
cord-301362-f3lp10lm	100	21	-	-	HYPH
cord-301362-f3lp10lm	100	22	induced	induce	VBN
cord-301362-f3lp10lm	100	23	antiviral	antiviral	JJ
cord-301362-f3lp10lm	100	24	response	response	NN
cord-301362-f3lp10lm	100	25	.	.	.
cord-301362-f3lp10lm	101	1	Semiliki	Semiliki	NNP
cord-301362-f3lp10lm	101	2	Forest	Forest	NNP
cord-301362-f3lp10lm	101	3	Virus	Virus	NNP
cord-301362-f3lp10lm	101	4	(	(	-LRB-
cord-301362-f3lp10lm	101	5	SFV	SFV	NNP
cord-301362-f3lp10lm	101	6	)	)	-RRB-
cord-301362-f3lp10lm	101	7	belongs	belong	VBZ
cord-301362-f3lp10lm	101	8	to	to	IN
cord-301362-f3lp10lm	101	9	the	the	DT
cord-301362-f3lp10lm	101	10	Togaviridae	Togaviridae	NNP
cord-301362-f3lp10lm	101	11	family	family	NN
cord-301362-f3lp10lm	101	12	,	,	,
cord-301362-f3lp10lm	101	13	which	which	WDT
cord-301362-f3lp10lm	101	14	comprises	comprise	VBZ
cord-301362-f3lp10lm	101	15	alphaviruses	alphaviruses	NNP
cord-301362-f3lp10lm	101	16	and	and	CC
cord-301362-f3lp10lm	101	17	the	the	DT
cord-301362-f3lp10lm	101	18	etiologic	etiologic	JJ
cord-301362-f3lp10lm	101	19	agent	agent	NN
cord-301362-f3lp10lm	101	20	of	of	IN
cord-301362-f3lp10lm	101	21	rubella	rubella	NN
cord-301362-f3lp10lm	101	22	,	,	,
cord-301362-f3lp10lm	101	23	the	the	DT
cord-301362-f3lp10lm	101	24	rubella	rubella	NN
cord-301362-f3lp10lm	101	25	virus	virus	NN
cord-301362-f3lp10lm	101	26	.	.	.
cord-301362-f3lp10lm	102	1	This	this	DT
cord-301362-f3lp10lm	102	2	family	family	NN
cord-301362-f3lp10lm	102	3	is	be	VBZ
cord-301362-f3lp10lm	102	4	,	,	,
cord-301362-f3lp10lm	102	5	to	to	IN
cord-301362-f3lp10lm	102	6	date	date	NN
cord-301362-f3lp10lm	102	7	,	,	,
cord-301362-f3lp10lm	102	8	the	the	DT
cord-301362-f3lp10lm	102	9	sole	sole	JJ
cord-301362-f3lp10lm	102	10	group	group	NN
cord-301362-f3lp10lm	102	11	of	of	IN
cord-301362-f3lp10lm	102	12	+	+	SYM
cord-301362-f3lp10lm	102	13	sRNA	srna	NN
cord-301362-f3lp10lm	102	14	viruses	virus	NNS
cord-301362-f3lp10lm	102	15	that	that	WDT
cord-301362-f3lp10lm	102	16	modify	modify	VBP
cord-301362-f3lp10lm	102	17	endosomal	endosomal	NN
cord-301362-f3lp10lm	102	18	and	and	CC
cord-301362-f3lp10lm	102	19	lysosomal	lysosomal	JJ
cord-301362-f3lp10lm	102	20	membranes	membrane	NNS
cord-301362-f3lp10lm	102	21	to	to	TO
cord-301362-f3lp10lm	102	22	replicate	replicate	VB
cord-301362-f3lp10lm	102	23	their	-PRON-	PRP$
cord-301362-f3lp10lm	102	24	genomes	genome	NNS
cord-301362-f3lp10lm	102	25	(	(	-LRB-
cord-301362-f3lp10lm	102	26	Froshauer	Froshauer	NNP
cord-301362-f3lp10lm	102	27	et	et	NNP
cord-301362-f3lp10lm	102	28	al	al	NNP
cord-301362-f3lp10lm	102	29	.	.	NNP
cord-301362-f3lp10lm	102	30	,	,	,
cord-301362-f3lp10lm	102	31	1988	1988	CD
cord-301362-f3lp10lm	102	32	;	;	:
cord-301362-f3lp10lm	102	33	Kujala	Kujala	NNP
cord-301362-f3lp10lm	102	34	et	et	NNP
cord-301362-f3lp10lm	102	35	al	al	NNP
cord-301362-f3lp10lm	102	36	.	.	NNP
cord-301362-f3lp10lm	102	37	,	,	,
cord-301362-f3lp10lm	102	38	1999	1999	CD
cord-301362-f3lp10lm	102	39	)	)	-RRB-
cord-301362-f3lp10lm	102	40	.	.	.
cord-301362-f3lp10lm	103	1	Alphaviruses	Alphaviruses	NNP
cord-301362-f3lp10lm	103	2	are	be	VBP
cord-301362-f3lp10lm	103	3	a	a	DT
cord-301362-f3lp10lm	103	4	genus	genus	NN
cord-301362-f3lp10lm	103	5	of	of	IN
cord-301362-f3lp10lm	103	6	viruses	virus	NNS
cord-301362-f3lp10lm	103	7	generally	generally	RB
cord-301362-f3lp10lm	103	8	transmitted	transmit	VBN
cord-301362-f3lp10lm	103	9	by	by	IN
cord-301362-f3lp10lm	103	10	mosquito	mosquito	NN
cord-301362-f3lp10lm	103	11	vectors	vector	NNS
cord-301362-f3lp10lm	103	12	,	,	,
cord-301362-f3lp10lm	103	13	which	which	WDT
cord-301362-f3lp10lm	103	14	replicate	replicate	VBP
cord-301362-f3lp10lm	103	15	inside	inside	IN
cord-301362-f3lp10lm	103	16	the	the	DT
cord-301362-f3lp10lm	103	17	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	103	18	of	of	IN
cord-301362-f3lp10lm	103	19	both	both	DT
cord-301362-f3lp10lm	103	20	,	,	,
cord-301362-f3lp10lm	103	21	invertebrate	invertebrate	JJ
cord-301362-f3lp10lm	103	22	and	and	CC
cord-301362-f3lp10lm	103	23	vertebrate	vertebrate	JJ
cord-301362-f3lp10lm	103	24	cells	cell	NNS
cord-301362-f3lp10lm	103	25	.	.	.
cord-301362-f3lp10lm	104	1	They	-PRON-	PRP
cord-301362-f3lp10lm	104	2	can	can	MD
cord-301362-f3lp10lm	104	3	infect	infect	VB
cord-301362-f3lp10lm	104	4	a	a	DT
cord-301362-f3lp10lm	104	5	variety	variety	NN
cord-301362-f3lp10lm	104	6	of	of	IN
cord-301362-f3lp10lm	104	7	hosts	host	NNS
cord-301362-f3lp10lm	104	8	including	include	VBG
cord-301362-f3lp10lm	104	9	small	small	JJ
cord-301362-f3lp10lm	104	10	and	and	CC
cord-301362-f3lp10lm	104	11	large	large	JJ
cord-301362-f3lp10lm	104	12	mammals	mammal	NNS
cord-301362-f3lp10lm	104	13	,	,	,
cord-301362-f3lp10lm	104	14	birds	bird	NNS
cord-301362-f3lp10lm	104	15	,	,	,
cord-301362-f3lp10lm	104	16	and	and	CC
cord-301362-f3lp10lm	104	17	humans	human	NNS
cord-301362-f3lp10lm	104	18	(	(	-LRB-
cord-301362-f3lp10lm	104	19	reviewed	review	VBN
cord-301362-f3lp10lm	104	20	by	by	IN
cord-301362-f3lp10lm	104	21	Kuhn	Kuhn	NNP
cord-301362-f3lp10lm	104	22	,	,	,
cord-301362-f3lp10lm	104	23	2013	2013	CD
cord-301362-f3lp10lm	104	24	)	)	-RRB-
cord-301362-f3lp10lm	104	25	.	.	.
cord-301362-f3lp10lm	105	1	Among	among	IN
cord-301362-f3lp10lm	105	2	alphaviruses	alphavirus	NNS
cord-301362-f3lp10lm	105	3	there	there	EX
cord-301362-f3lp10lm	105	4	are	be	VBP
cord-301362-f3lp10lm	105	5	several	several	JJ
cord-301362-f3lp10lm	105	6	important	important	JJ
cord-301362-f3lp10lm	105	7	pathogens	pathogen	NNS
cord-301362-f3lp10lm	105	8	affecting	affect	VBG
cord-301362-f3lp10lm	105	9	human	human	JJ
cord-301362-f3lp10lm	105	10	and	and	CC
cord-301362-f3lp10lm	105	11	other	other	JJ
cord-301362-f3lp10lm	105	12	animals	animal	NNS
cord-301362-f3lp10lm	105	13	,	,	,
cord-301362-f3lp10lm	105	14	including	include	VBG
cord-301362-f3lp10lm	105	15	the	the	DT
cord-301362-f3lp10lm	105	16	encephalitogenic	encephalitogenic	NNP
cord-301362-f3lp10lm	105	17	alphaviruses	alphavirus	NNS
cord-301362-f3lp10lm	105	18	that	that	WDT
cord-301362-f3lp10lm	105	19	affect	affect	VBP
cord-301362-f3lp10lm	105	20	horses	horse	NNS
cord-301362-f3lp10lm	105	21	(	(	-LRB-
cord-301362-f3lp10lm	105	22	e.g.	e.g.	RB
cord-301362-f3lp10lm	105	23	,	,	,
cord-301362-f3lp10lm	105	24	Western	western	JJ
cord-301362-f3lp10lm	105	25	,	,	,
cord-301362-f3lp10lm	105	26	Eastern	eastern	JJ
cord-301362-f3lp10lm	105	27	,	,	,
cord-301362-f3lp10lm	105	28	and	and	CC
cord-301362-f3lp10lm	105	29	Venezuelan	venezuelan	JJ
cord-301362-f3lp10lm	105	30	equine	equine	NN
cord-301362-f3lp10lm	105	31	encephalitis	encephalitis	NN
cord-301362-f3lp10lm	105	32	viruses	virus	NNS
cord-301362-f3lp10lm	105	33	)	)	-RRB-
cord-301362-f3lp10lm	105	34	and	and	CC
cord-301362-f3lp10lm	105	35	the	the	DT
cord-301362-f3lp10lm	105	36	recently	recently	RB
cord-301362-f3lp10lm	105	37	re	re	VBN
cord-301362-f3lp10lm	105	38	-	-	JJ
cord-301362-f3lp10lm	105	39	emerging	emerge	VBG
cord-301362-f3lp10lm	105	40	chikungunya	chikungunya	NN
cord-301362-f3lp10lm	105	41	virus	virus	NN
cord-301362-f3lp10lm	105	42	(	(	-LRB-
cord-301362-f3lp10lm	105	43	CHIKV	CHIKV	NNP
cord-301362-f3lp10lm	105	44	)	)	-RRB-
cord-301362-f3lp10lm	105	45	.	.	.
cord-301362-f3lp10lm	106	1	CHIKV	CHIKV	NNP
cord-301362-f3lp10lm	106	2	re	re	VBD
cord-301362-f3lp10lm	106	3	-	-	VBD
cord-301362-f3lp10lm	106	4	emerged	emerge	VBD
cord-301362-f3lp10lm	106	5	in	in	IN
cord-301362-f3lp10lm	106	6	2004	2004	CD
cord-301362-f3lp10lm	106	7	to	to	TO
cord-301362-f3lp10lm	106	8	cause	cause	VB
cord-301362-f3lp10lm	106	9	outbreaks	outbreak	NNS
cord-301362-f3lp10lm	106	10	of	of	IN
cord-301362-f3lp10lm	106	11	millions	million	NNS
cord-301362-f3lp10lm	106	12	of	of	IN
cord-301362-f3lp10lm	106	13	cases	case	NNS
cord-301362-f3lp10lm	106	14	in	in	IN
cord-301362-f3lp10lm	106	15	countries	country	NNS
cord-301362-f3lp10lm	106	16	around	around	IN
cord-301362-f3lp10lm	106	17	the	the	DT
cord-301362-f3lp10lm	106	18	Indian	Indian	NNP
cord-301362-f3lp10lm	106	19	Ocean	Ocean	NNP
cord-301362-f3lp10lm	106	20	area	area	NN
cord-301362-f3lp10lm	106	21	,	,	,
cord-301362-f3lp10lm	106	22	in	in	IN
cord-301362-f3lp10lm	106	23	Asia	Asia	NNP
cord-301362-f3lp10lm	106	24	,	,	,
cord-301362-f3lp10lm	106	25	and	and	CC
cord-301362-f3lp10lm	106	26	recently	recently	RB
cord-301362-f3lp10lm	106	27	the	the	DT
cord-301362-f3lp10lm	106	28	Caribbean	Caribbean	NNP
cord-301362-f3lp10lm	106	29	(	(	-LRB-
cord-301362-f3lp10lm	106	30	http://www.cdc.gov/	http://www.cdc.gov/	NNP
cord-301362-f3lp10lm	106	31	chikungunya	chikungunya	NN
cord-301362-f3lp10lm	106	32	/	/	SYM
cord-301362-f3lp10lm	106	33	geo	geo	NNP
cord-301362-f3lp10lm	106	34	)	)	-RRB-
cord-301362-f3lp10lm	106	35	.	.	.
cord-301362-f3lp10lm	107	1	CHIK	CHIK	NNP
cord-301362-f3lp10lm	107	2	causes	cause	VBZ
cord-301362-f3lp10lm	107	3	painful	painful	JJ
cord-301362-f3lp10lm	107	4	arthritis	arthritis	NN
cord-301362-f3lp10lm	107	5	with	with	IN
cord-301362-f3lp10lm	107	6	symptoms	symptom	NNS
cord-301362-f3lp10lm	107	7	that	that	WDT
cord-301362-f3lp10lm	107	8	can	can	MD
cord-301362-f3lp10lm	107	9	persist	persist	VB
cord-301362-f3lp10lm	107	10	for	for	IN
cord-301362-f3lp10lm	107	11	years	year	NNS
cord-301362-f3lp10lm	107	12	,	,	,
cord-301362-f3lp10lm	107	13	and	and	CC
cord-301362-f3lp10lm	107	14	can	can	MD
cord-301362-f3lp10lm	107	15	also	also	RB
cord-301362-f3lp10lm	107	16	cause	cause	VB
cord-301362-f3lp10lm	107	17	neurological	neurological	JJ
cord-301362-f3lp10lm	107	18	complications	complication	NNS
cord-301362-f3lp10lm	107	19	and	and	CC
cord-301362-f3lp10lm	107	20	neonatal	neonatal	JJ
cord-301362-f3lp10lm	107	21	encephalitis	encephalitis	NN
cord-301362-f3lp10lm	107	22	(	(	-LRB-
cord-301362-f3lp10lm	107	23	Schwartz	Schwartz	NNP
cord-301362-f3lp10lm	107	24	and	and	CC
cord-301362-f3lp10lm	107	25	Albert	Albert	NNP
cord-301362-f3lp10lm	107	26	,	,	,
cord-301362-f3lp10lm	107	27	2010	2010	CD
cord-301362-f3lp10lm	107	28	)	)	-RRB-
cord-301362-f3lp10lm	107	29	.	.	.
cord-301362-f3lp10lm	108	1	SFV	SFV	NNP
cord-301362-f3lp10lm	108	2	and	and	CC
cord-301362-f3lp10lm	108	3	CHIKV	CHIKV	NNP
cord-301362-f3lp10lm	108	4	are	be	VBP
cord-301362-f3lp10lm	108	5	very	very	RB
cord-301362-f3lp10lm	108	6	similar	similar	JJ
cord-301362-f3lp10lm	108	7	in	in	IN
cord-301362-f3lp10lm	108	8	terms	term	NNS
cord-301362-f3lp10lm	108	9	of	of	IN
cord-301362-f3lp10lm	108	10	molecular	molecular	JJ
cord-301362-f3lp10lm	108	11	and	and	CC
cord-301362-f3lp10lm	108	12	cell	cell	NN
cord-301362-f3lp10lm	108	13	biology	biology	NN
cord-301362-f3lp10lm	108	14	,	,	,
cord-301362-f3lp10lm	108	15	e.g.	e.g.	RB
cord-301362-f3lp10lm	108	16	,	,	,
cord-301362-f3lp10lm	108	17	regarding	regard	VBG
cord-301362-f3lp10lm	108	18	replication	replication	NN
cord-301362-f3lp10lm	108	19	and	and	CC
cord-301362-f3lp10lm	108	20	molecular	molecular	JJ
cord-301362-f3lp10lm	108	21	interactions	interaction	NNS
cord-301362-f3lp10lm	108	22	,	,	,
cord-301362-f3lp10lm	108	23	but	but	CC
cord-301362-f3lp10lm	108	24	are	be	VBP
cord-301362-f3lp10lm	108	25	strikingly	strikingly	RB
cord-301362-f3lp10lm	108	26	different	different	JJ
cord-301362-f3lp10lm	108	27	regarding	regard	VBG
cord-301362-f3lp10lm	108	28	pathology	pathology	NN
cord-301362-f3lp10lm	108	29	:	:	:
cord-301362-f3lp10lm	108	30	CHIKV	CHIKV	NNP
cord-301362-f3lp10lm	108	31	is	be	VBZ
cord-301362-f3lp10lm	108	32	a	a	DT
cord-301362-f3lp10lm	108	33	relevant	relevant	JJ
cord-301362-f3lp10lm	108	34	human	human	JJ
cord-301362-f3lp10lm	108	35	pathogen	pathogen	NN
cord-301362-f3lp10lm	108	36	,	,	,
cord-301362-f3lp10lm	108	37	while	while	IN
cord-301362-f3lp10lm	108	38	SFV	SFV	NNP
cord-301362-f3lp10lm	108	39	is	be	VBZ
cord-301362-f3lp10lm	108	40	a	a	DT
cord-301362-f3lp10lm	108	41	lowpathogenic	lowpathogenic	JJ
cord-301362-f3lp10lm	108	42	model	model	NN
cord-301362-f3lp10lm	108	43	virus	virus	NN
cord-301362-f3lp10lm	108	44	,	,	,
cord-301362-f3lp10lm	108	45	albeit	albeit	IN
cord-301362-f3lp10lm	108	46	neuropathogenic	neuropathogenic	NNP
cord-301362-f3lp10lm	108	47	in	in	IN
cord-301362-f3lp10lm	108	48	mice	mouse	NNS
cord-301362-f3lp10lm	109	1	(	(	-LRB-
cord-301362-f3lp10lm	109	2	Atkins	Atkins	NNP
cord-301362-f3lp10lm	109	3	et	et	NNP
cord-301362-f3lp10lm	109	4	al	al	NNP
cord-301362-f3lp10lm	109	5	.	.	NNP
cord-301362-f3lp10lm	109	6	,	,	,
cord-301362-f3lp10lm	109	7	1999	1999	CD
cord-301362-f3lp10lm	109	8	)	)	-RRB-
cord-301362-f3lp10lm	110	1	.There	.There	NFP
cord-301362-f3lp10lm	110	2	are	be	VBP
cord-301362-f3lp10lm	110	3	currently	currently	RB
cord-301362-f3lp10lm	110	4	no	no	DT
cord-301362-f3lp10lm	110	5	effective	effective	JJ
cord-301362-f3lp10lm	110	6	vaccines	vaccine	NNS
cord-301362-f3lp10lm	110	7	or	or	CC
cord-301362-f3lp10lm	110	8	treatments	treatment	NNS
cord-301362-f3lp10lm	110	9	for	for	IN
cord-301362-f3lp10lm	110	10	human	human	JJ
cord-301362-f3lp10lm	110	11	alphavirus	alphavirus	NN
cord-301362-f3lp10lm	110	12	infections	infection	NNS
cord-301362-f3lp10lm	110	13	.	.	.
cord-301362-f3lp10lm	111	1	Alphaviruses	alphavirus	NNS
cord-301362-f3lp10lm	111	2	are	be	VBP
cord-301362-f3lp10lm	111	3	small	small	JJ
cord-301362-f3lp10lm	111	4	-	-	HYPH
cord-301362-f3lp10lm	111	5	enveloped	envelop	VBN
cord-301362-f3lp10lm	111	6	particles	particle	NNS
cord-301362-f3lp10lm	111	7	that	that	WDT
cord-301362-f3lp10lm	111	8	enter	enter	VBP
cord-301362-f3lp10lm	111	9	the	the	DT
cord-301362-f3lp10lm	111	10	cell	cell	NN
cord-301362-f3lp10lm	111	11	by	by	IN
cord-301362-f3lp10lm	111	12	clathrin	clathrin	NN
cord-301362-f3lp10lm	111	13	-	-	HYPH
cord-301362-f3lp10lm	111	14	mediated	mediate	VBN
cord-301362-f3lp10lm	111	15	endocytosis	endocytosis	NN
cord-301362-f3lp10lm	111	16	(	(	-LRB-
cord-301362-f3lp10lm	111	17	reviewed	review	VBN
cord-301362-f3lp10lm	111	18	by	by	IN
cord-301362-f3lp10lm	111	19	Kielian	Kielian	NNP
cord-301362-f3lp10lm	111	20	et	et	NNP
cord-301362-f3lp10lm	111	21	al	al	NNP
cord-301362-f3lp10lm	111	22	.	.	NNP
cord-301362-f3lp10lm	111	23	,	,	,
cord-301362-f3lp10lm	111	24	2010	2010	CD
cord-301362-f3lp10lm	111	25	)	)	-RRB-
cord-301362-f3lp10lm	111	26	,	,	,
cord-301362-f3lp10lm	111	27	followed	follow	VBN
cord-301362-f3lp10lm	111	28	by	by	IN
cord-301362-f3lp10lm	111	29	fusion	fusion	NN
cord-301362-f3lp10lm	111	30	of	of	IN
cord-301362-f3lp10lm	111	31	the	the	DT
cord-301362-f3lp10lm	111	32	virus	virus	NN
cord-301362-f3lp10lm	111	33	envelope	envelope	NN
cord-301362-f3lp10lm	111	34	with	with	IN
cord-301362-f3lp10lm	111	35	early	early	JJ
cord-301362-f3lp10lm	111	36	endosomal	endosomal	NNP
cord-301362-f3lp10lm	111	37	membranes	membrane	NNS
cord-301362-f3lp10lm	111	38	leading	lead	VBG
cord-301362-f3lp10lm	111	39	to	to	IN
cord-301362-f3lp10lm	111	40	nucleocapsid	nucleocapsid	NNP
cord-301362-f3lp10lm	111	41	core	core	JJ
cord-301362-f3lp10lm	111	42	delivery	delivery	NN
cord-301362-f3lp10lm	111	43	into	into	IN
cord-301362-f3lp10lm	111	44	the	the	DT
cord-301362-f3lp10lm	111	45	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	112	1	(	(	-LRB-
cord-301362-f3lp10lm	112	2	Gibbons	Gibbons	NNP
cord-301362-f3lp10lm	112	3	et	et	NNP
cord-301362-f3lp10lm	112	4	al	al	NNP
cord-301362-f3lp10lm	112	5	.	.	NNP
cord-301362-f3lp10lm	112	6	,	,	,
cord-301362-f3lp10lm	112	7	2004	2004	CD
cord-301362-f3lp10lm	112	8	)	)	-RRB-
cord-301362-f3lp10lm	112	9	.	.	.
cord-301362-f3lp10lm	113	1	The	the	DT
cord-301362-f3lp10lm	113	2	viral	viral	JJ
cord-301362-f3lp10lm	113	3	nucleocapsid	nucleocapsid	NN
cord-301362-f3lp10lm	113	4	is	be	VBZ
cord-301362-f3lp10lm	113	5	disassembled	disassemble	VBN
cord-301362-f3lp10lm	113	6	with	with	IN
cord-301362-f3lp10lm	113	7	the	the	DT
cord-301362-f3lp10lm	113	8	aide	aide	NN
cord-301362-f3lp10lm	113	9	of	of	IN
cord-301362-f3lp10lm	113	10	ribosomes	ribosome	NNS
cord-301362-f3lp10lm	113	11	,	,	,
cord-301362-f3lp10lm	113	12	which	which	WDT
cord-301362-f3lp10lm	113	13	have	have	VBP
cord-301362-f3lp10lm	113	14	affinity	affinity	NN
cord-301362-f3lp10lm	113	15	for	for	IN
cord-301362-f3lp10lm	113	16	the	the	DT
cord-301362-f3lp10lm	113	17	capsid	capsid	NN
cord-301362-f3lp10lm	113	18	protein	protein	NN
cord-301362-f3lp10lm	113	19	(	(	-LRB-
cord-301362-f3lp10lm	113	20	Singh	Singh	NNP
cord-301362-f3lp10lm	113	21	and	and	CC
cord-301362-f3lp10lm	113	22	Helenius	Helenius	NNP
cord-301362-f3lp10lm	113	23	,	,	,
cord-301362-f3lp10lm	113	24	1992	1992	CD
cord-301362-f3lp10lm	113	25	)	)	-RRB-
cord-301362-f3lp10lm	113	26	.	.	.
cord-301362-f3lp10lm	114	1	The	the	DT
cord-301362-f3lp10lm	114	2	SFV	SFV	NNP
cord-301362-f3lp10lm	114	3	genome	genome	NN
cord-301362-f3lp10lm	114	4	,	,	,
cord-301362-f3lp10lm	114	5	∼11.5	∼11.5	NNP
cord-301362-f3lp10lm	114	6	kb	kb	NNP
cord-301362-f3lp10lm	114	7	long	long	RB
cord-301362-f3lp10lm	114	8	with	with	IN
cord-301362-f3lp10lm	114	9	a	a	DT
cord-301362-f3lp10lm	114	10	5	5	CD
cord-301362-f3lp10lm	114	11	′	′	CD
cord-301362-f3lp10lm	114	12	cap	cap	NN
cord-301362-f3lp10lm	114	13	structure	structure	NN
cord-301362-f3lp10lm	114	14	and	and	CC
cord-301362-f3lp10lm	114	15	3	3	CD
cord-301362-f3lp10lm	114	16	′	′	CD
cord-301362-f3lp10lm	114	17	poly	poly	NNP
cord-301362-f3lp10lm	114	18	(	(	-LRB-
cord-301362-f3lp10lm	114	19	A	a	NN
cord-301362-f3lp10lm	114	20	)	)	-RRB-
cord-301362-f3lp10lm	114	21	sequence	sequence	NN
cord-301362-f3lp10lm	114	22	,	,	,
cord-301362-f3lp10lm	114	23	is	be	VBZ
cord-301362-f3lp10lm	114	24	translated	translate	VBN
cord-301362-f3lp10lm	114	25	into	into	IN
cord-301362-f3lp10lm	114	26	a	a	DT
cord-301362-f3lp10lm	114	27	replicase	replicase	NN
cord-301362-f3lp10lm	114	28	polyprotein	polyprotein	NN
cord-301362-f3lp10lm	114	29	,	,	,
cord-301362-f3lp10lm	114	30	which	which	WDT
cord-301362-f3lp10lm	114	31	consists	consist	VBZ
cord-301362-f3lp10lm	114	32	in	in	IN
cord-301362-f3lp10lm	114	33	four	four	CD
cord-301362-f3lp10lm	114	34	non	non	JJ
cord-301362-f3lp10lm	114	35	-	-	JJ
cord-301362-f3lp10lm	114	36	structural	structural	JJ
cord-301362-f3lp10lm	114	37	proteins	protein	NNS
cord-301362-f3lp10lm	114	38	(	(	-LRB-
cord-301362-f3lp10lm	114	39	nsP1-nsP4	nsP1-nsP4	NNS
cord-301362-f3lp10lm	114	40	)	)	-RRB-
cord-301362-f3lp10lm	114	41	,	,	,
cord-301362-f3lp10lm	114	42	involved	involve	VBN
cord-301362-f3lp10lm	114	43	in	in	IN
cord-301362-f3lp10lm	114	44	viral	viral	JJ
cord-301362-f3lp10lm	114	45	RNA	RNA	NNP
cord-301362-f3lp10lm	114	46	synthesis	synthesis	NN
cord-301362-f3lp10lm	114	47	,	,	,
cord-301362-f3lp10lm	114	48	and	and	CC
cord-301362-f3lp10lm	114	49	five	five	CD
cord-301362-f3lp10lm	114	50	structural	structural	JJ
cord-301362-f3lp10lm	114	51	proteins	protein	NNS
cord-301362-f3lp10lm	114	52	.	.	.
cord-301362-f3lp10lm	115	1	The	the	DT
cord-301362-f3lp10lm	115	2	replicase	replicase	NN
cord-301362-f3lp10lm	115	3	complex	complex	NN
cord-301362-f3lp10lm	115	4	[	[	-LRB-
cord-301362-f3lp10lm	115	5	RNA	rna	NN
cord-301362-f3lp10lm	115	6	-	-	HYPH
cord-301362-f3lp10lm	115	7	dependent	dependent	JJ
cord-301362-f3lp10lm	115	8	RNA	RNA	NNP
cord-301362-f3lp10lm	115	9	polymerases	polymerase	NNS
cord-301362-f3lp10lm	115	10	(	(	-LRB-
cord-301362-f3lp10lm	115	11	RdRp	RdRp	NNP
cord-301362-f3lp10lm	115	12	)	)	-RRB-
cord-301362-f3lp10lm	115	13	]	]	-RRB-
cord-301362-f3lp10lm	115	14	is	be	VBZ
cord-301362-f3lp10lm	115	15	remodeled	remodel	VBN
cord-301362-f3lp10lm	115	16	by	by	IN
cord-301362-f3lp10lm	115	17	the	the	DT
cord-301362-f3lp10lm	115	18	viral	viral	JJ
cord-301362-f3lp10lm	115	19	protease	protease	NN
cord-301362-f3lp10lm	115	20	nsP2	nsp2	CC
cord-301362-f3lp10lm	115	21	through	through	IN
cord-301362-f3lp10lm	115	22	sequential	sequential	JJ
cord-301362-f3lp10lm	115	23	cleavages	cleavage	NNS
cord-301362-f3lp10lm	115	24	to	to	TO
cord-301362-f3lp10lm	115	25	give	give	VB
cord-301362-f3lp10lm	115	26	rise	rise	NN
cord-301362-f3lp10lm	115	27	to	to	IN
cord-301362-f3lp10lm	115	28	the	the	DT
cord-301362-f3lp10lm	115	29	four	four	CD
cord-301362-f3lp10lm	115	30	different	different	JJ
cord-301362-f3lp10lm	115	31	units	unit	NNS
cord-301362-f3lp10lm	115	32	nsP1	nsp1	NN
cord-301362-f3lp10lm	115	33	,	,	,
cord-301362-f3lp10lm	115	34	nsP2	nsP2	NNP
cord-301362-f3lp10lm	115	35	,	,	,
cord-301362-f3lp10lm	115	36	nsP3	nsP3	NNS
cord-301362-f3lp10lm	115	37	,	,	,
cord-301362-f3lp10lm	115	38	and	and	CC
cord-301362-f3lp10lm	115	39	nsP4	nsP4	NNP
cord-301362-f3lp10lm	115	40	.	.	.
cord-301362-f3lp10lm	116	1	These	these	DT
cord-301362-f3lp10lm	116	2	four	four	CD
cord-301362-f3lp10lm	116	3	units	unit	NNS
cord-301362-f3lp10lm	116	4	form	form	VBP
cord-301362-f3lp10lm	116	5	a	a	DT
cord-301362-f3lp10lm	116	6	macromolecular	macromolecular	JJ
cord-301362-f3lp10lm	116	7	arrangement	arrangement	NN
cord-301362-f3lp10lm	116	8	responsible	responsible	JJ
cord-301362-f3lp10lm	116	9	of	of	IN
cord-301362-f3lp10lm	116	10	viral	viral	JJ
cord-301362-f3lp10lm	116	11	genome	genome	NN
cord-301362-f3lp10lm	116	12	replication	replication	NN
cord-301362-f3lp10lm	116	13	,	,	,
cord-301362-f3lp10lm	116	14	which	which	WDT
cord-301362-f3lp10lm	116	15	also	also	RB
cord-301362-f3lp10lm	116	16	contains	contain	VBZ
cord-301362-f3lp10lm	116	17	RNA	RNA	NNP
cord-301362-f3lp10lm	116	18	originated	originate	VBD
cord-301362-f3lp10lm	116	19	from	from	IN
cord-301362-f3lp10lm	116	20	newly	newly	RB
cord-301362-f3lp10lm	116	21	synthesis	synthesis	NN
cord-301362-f3lp10lm	116	22	(	(	-LRB-
cord-301362-f3lp10lm	116	23	Kujala	Kujala	NNP
cord-301362-f3lp10lm	116	24	et	et	NNP
cord-301362-f3lp10lm	116	25	al	al	NNP
cord-301362-f3lp10lm	116	26	.	.	NNP
cord-301362-f3lp10lm	116	27	,	,	,
cord-301362-f3lp10lm	116	28	2001	2001	CD
cord-301362-f3lp10lm	116	29	)	)	-RRB-
cord-301362-f3lp10lm	116	30	.	.	.
cord-301362-f3lp10lm	117	1	However	however	RB
cord-301362-f3lp10lm	117	2	,	,	,
cord-301362-f3lp10lm	117	3	the	the	DT
cord-301362-f3lp10lm	117	4	RdRp	RdRp	NNP
cord-301362-f3lp10lm	117	5	core	core	NN
cord-301362-f3lp10lm	117	6	is	be	VBZ
cord-301362-f3lp10lm	117	7	formed	form	VBN
cord-301362-f3lp10lm	117	8	by	by	IN
cord-301362-f3lp10lm	117	9	nsP4	nsP4	NNP
cord-301362-f3lp10lm	117	10	,	,	,
cord-301362-f3lp10lm	117	11	which	which	WDT
cord-301362-f3lp10lm	117	12	harbors	harbor	VBZ
cord-301362-f3lp10lm	117	13	a	a	DT
cord-301362-f3lp10lm	117	14	conserved	conserved	JJ
cord-301362-f3lp10lm	117	15	catalytic	catalytic	JJ
cord-301362-f3lp10lm	117	16	Gly	Gly	NNP
cord-301362-f3lp10lm	117	17	-	-	HYPH
cord-301362-f3lp10lm	117	18	Asp	Asp	NNP
cord-301362-f3lp10lm	117	19	-	-	HYPH
cord-301362-f3lp10lm	117	20	Asp	Asp	NNP
cord-301362-f3lp10lm	117	21	triad	triad	NN
cord-301362-f3lp10lm	117	22	(	(	-LRB-
cord-301362-f3lp10lm	117	23	Kamer	Kamer	NNP
cord-301362-f3lp10lm	117	24	and	and	CC
cord-301362-f3lp10lm	117	25	Argos	Argos	NNP
cord-301362-f3lp10lm	117	26	,	,	,
cord-301362-f3lp10lm	117	27	1984	1984	CD
cord-301362-f3lp10lm	117	28	)	)	-RRB-
cord-301362-f3lp10lm	117	29	.	.	.
cord-301362-f3lp10lm	118	1	Together	together	RB
cord-301362-f3lp10lm	118	2	,	,	,
cord-301362-f3lp10lm	118	3	they	-PRON-	PRP
cord-301362-f3lp10lm	118	4	give	give	VBP
cord-301362-f3lp10lm	118	5	rise	rise	NN
cord-301362-f3lp10lm	118	6	to	to	IN
cord-301362-f3lp10lm	118	7	replication	replication	NN
cord-301362-f3lp10lm	118	8	complexes	complex	NNS
cord-301362-f3lp10lm	118	9	(	(	-LRB-
cord-301362-f3lp10lm	118	10	RCs	RCs	NNP
cord-301362-f3lp10lm	118	11	)	)	-RRB-
cord-301362-f3lp10lm	118	12	colocalizing	colocalize	VBG
cord-301362-f3lp10lm	118	13	to	to	IN
cord-301362-f3lp10lm	118	14	bulb	bulb	NN
cord-301362-f3lp10lm	118	15	-	-	HYPH
cord-301362-f3lp10lm	118	16	shaped	shape	VBN
cord-301362-f3lp10lm	118	17	membrane	membrane	NN
cord-301362-f3lp10lm	118	18	invaginations	invagination	NNS
cord-301362-f3lp10lm	118	19	designated	designate	VBN
cord-301362-f3lp10lm	118	20	spherules	spherule	NNS
cord-301362-f3lp10lm	118	21	(	(	-LRB-
cord-301362-f3lp10lm	118	22	Kujala	Kujala	NNP
cord-301362-f3lp10lm	118	23	et	et	NNP
cord-301362-f3lp10lm	118	24	al	al	NNP
cord-301362-f3lp10lm	118	25	.	.	NNP
cord-301362-f3lp10lm	118	26	,	,	,
cord-301362-f3lp10lm	118	27	2001	2001	CD
cord-301362-f3lp10lm	118	28	;	;	:
cord-301362-f3lp10lm	119	1	Salonen	Salonen	NNP
cord-301362-f3lp10lm	119	2	et	et	NNP
cord-301362-f3lp10lm	119	3	al	al	NNP
cord-301362-f3lp10lm	119	4	.	.	.
cord-301362-f3lp10lm	120	1	,	,	,
cord-301362-f3lp10lm	120	2	2003	2003	CD
cord-301362-f3lp10lm	120	3	;	;	:
cord-301362-f3lp10lm	120	4	Spuul	Spuul	NNP
cord-301362-f3lp10lm	120	5	et	et	NNP
cord-301362-f3lp10lm	120	6	al	al	NNP
cord-301362-f3lp10lm	120	7	.	.	NNP
cord-301362-f3lp10lm	120	8	,	,	,
cord-301362-f3lp10lm	120	9	2010	2010	CD
cord-301362-f3lp10lm	120	10	)	)	-RRB-
cord-301362-f3lp10lm	120	11	.	.	.
cord-301362-f3lp10lm	121	1	These	these	DT
cord-301362-f3lp10lm	121	2	spherules	spherule	NNS
cord-301362-f3lp10lm	121	3	,	,	,
cord-301362-f3lp10lm	121	4	thanks	thank	NNS
cord-301362-f3lp10lm	121	5	to	to	IN
cord-301362-f3lp10lm	121	6	their	-PRON-	PRP$
cord-301362-f3lp10lm	121	7	homogenous	homogenous	JJ
cord-301362-f3lp10lm	121	8	size	size	NN
cord-301362-f3lp10lm	121	9	,	,	,
cord-301362-f3lp10lm	121	10	defined	define	VBN
cord-301362-f3lp10lm	121	11	morphology	morphology	NN
cord-301362-f3lp10lm	121	12	and	and	CC
cord-301362-f3lp10lm	121	13	electron	electron	NN
cord-301362-f3lp10lm	121	14	density	density	NN
cord-301362-f3lp10lm	121	15	in	in	IN
cord-301362-f3lp10lm	121	16	infected	infect	VBN
cord-301362-f3lp10lm	121	17	-	-	HYPH
cord-301362-f3lp10lm	121	18	cells	cell	NNS
cord-301362-f3lp10lm	121	19	,	,	,
cord-301362-f3lp10lm	121	20	were	be	VBD
cord-301362-f3lp10lm	121	21	firstly	firstly	RB
cord-301362-f3lp10lm	121	22	described	describe	VBN
cord-301362-f3lp10lm	121	23	between	between	IN
cord-301362-f3lp10lm	121	24	late	late	JJ
cord-301362-f3lp10lm	121	25	1960s	1960	NNS
cord-301362-f3lp10lm	121	26	and	and	CC
cord-301362-f3lp10lm	121	27	early	early	JJ
cord-301362-f3lp10lm	121	28	1970s	1970	NNS
cord-301362-f3lp10lm	121	29	(	(	-LRB-
cord-301362-f3lp10lm	121	30	Friedman	Friedman	NNP
cord-301362-f3lp10lm	121	31	and	and	CC
cord-301362-f3lp10lm	121	32	Berezesky	Berezesky	NNP
cord-301362-f3lp10lm	121	33	,	,	,
cord-301362-f3lp10lm	121	34	1967	1967	CD
cord-301362-f3lp10lm	121	35	;	;	.
cord-301362-f3lp10lm	122	1	Grimley	Grimley	NNP
cord-301362-f3lp10lm	122	2	et	et	NNP
cord-301362-f3lp10lm	122	3	al	al	NNP
cord-301362-f3lp10lm	122	4	.	.	.
cord-301362-f3lp10lm	123	1	,	,	,
cord-301362-f3lp10lm	123	2	1968	1968	CD
cord-301362-f3lp10lm	123	3	;	;	:
cord-301362-f3lp10lm	123	4	Friedman	Friedman	NNP
cord-301362-f3lp10lm	123	5	et	et	NNP
cord-301362-f3lp10lm	123	6	al	al	NNP
cord-301362-f3lp10lm	123	7	.	.	NNP
cord-301362-f3lp10lm	123	8	,	,	,
cord-301362-f3lp10lm	123	9	1972	1972	CD
cord-301362-f3lp10lm	123	10	)	)	-RRB-
cord-301362-f3lp10lm	123	11	.	.	.
cord-301362-f3lp10lm	124	1	At	at	IN
cord-301362-f3lp10lm	124	2	that	that	DT
cord-301362-f3lp10lm	124	3	time	time	NN
cord-301362-f3lp10lm	124	4	,	,	,
cord-301362-f3lp10lm	124	5	the	the	DT
cord-301362-f3lp10lm	124	6	spherules	spherule	NNS
cord-301362-f3lp10lm	124	7	were	be	VBD
cord-301362-f3lp10lm	124	8	described	describe	VBN
cord-301362-f3lp10lm	124	9	to	to	TO
cord-301362-f3lp10lm	124	10	have	have	VB
cord-301362-f3lp10lm	124	11	a	a	DT
cord-301362-f3lp10lm	124	12	diameter	diameter	NN
cord-301362-f3lp10lm	124	13	of	of	IN
cord-301362-f3lp10lm	124	14	∼50	∼50	NNP
cord-301362-f3lp10lm	124	15	nm	nm	NNP
cord-301362-f3lp10lm	124	16	and	and	CC
cord-301362-f3lp10lm	124	17	were	be	VBD
cord-301362-f3lp10lm	124	18	found	find	VBN
cord-301362-f3lp10lm	124	19	located	locate	VBN
cord-301362-f3lp10lm	124	20	in	in	IN
cord-301362-f3lp10lm	124	21	the	the	DT
cord-301362-f3lp10lm	124	22	membranes	membrane	NNS
cord-301362-f3lp10lm	124	23	of	of	IN
cord-301362-f3lp10lm	124	24	large	large	JJ
cord-301362-f3lp10lm	124	25	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	124	26	compartments	compartment	NNS
cord-301362-f3lp10lm	124	27	,	,	,
cord-301362-f3lp10lm	124	28	which	which	WDT
cord-301362-f3lp10lm	124	29	were	be	VBD
cord-301362-f3lp10lm	124	30	termed	term	VBN
cord-301362-f3lp10lm	124	31	virus	virus	NN
cord-301362-f3lp10lm	124	32	-	-	HYPH
cord-301362-f3lp10lm	124	33	induced	induce	VBN
cord-301362-f3lp10lm	124	34	cytopathic	cytopathic	JJ
cord-301362-f3lp10lm	124	35	vacuole	vacuole	NN
cord-301362-f3lp10lm	124	36	of	of	IN
cord-301362-f3lp10lm	124	37	type	type	NN
cord-301362-f3lp10lm	124	38	I	-PRON-	PRP
cord-301362-f3lp10lm	124	39	(	(	-LRB-
cord-301362-f3lp10lm	124	40	CPV	CPV	NNP
cord-301362-f3lp10lm	124	41	-	-	HYPH
cord-301362-f3lp10lm	124	42	I	i	NN
cord-301362-f3lp10lm	124	43	)	)	-RRB-
cord-301362-f3lp10lm	124	44	(	(	-LRB-
cord-301362-f3lp10lm	124	45	Grimley	Grimley	NNP
cord-301362-f3lp10lm	124	46	et	et	NNP
cord-301362-f3lp10lm	124	47	al	al	NNP
cord-301362-f3lp10lm	124	48	.	.	NNP
cord-301362-f3lp10lm	124	49	,	,	,
cord-301362-f3lp10lm	124	50	1968	1968	CD
cord-301362-f3lp10lm	124	51	)	)	-RRB-
cord-301362-f3lp10lm	124	52	.	.	.
cord-301362-f3lp10lm	125	1	Subsequently	subsequently	RB
cord-301362-f3lp10lm	125	2	,	,	,
cord-301362-f3lp10lm	125	3	Froshauer	Froshauer	NNP
cord-301362-f3lp10lm	125	4	et	et	NNP
cord-301362-f3lp10lm	125	5	al	al	NNP
cord-301362-f3lp10lm	125	6	.	.	NNP
cord-301362-f3lp10lm	125	7	demonstrated	demonstrate	VBD
cord-301362-f3lp10lm	125	8	that	that	IN
cord-301362-f3lp10lm	125	9	the	the	DT
cord-301362-f3lp10lm	125	10	spherules	spherule	NNS
cord-301362-f3lp10lm	125	11	contained	contain	VBD
cord-301362-f3lp10lm	125	12	endosomal	endosomal	NNP
cord-301362-f3lp10lm	125	13	and	and	CC
cord-301362-f3lp10lm	125	14	lysosomal	lysosomal	JJ
cord-301362-f3lp10lm	125	15	markers	marker	NNS
cord-301362-f3lp10lm	125	16	and	and	CC
cord-301362-f3lp10lm	125	17	,	,	,
cord-301362-f3lp10lm	125	18	employing	employ	VBG
cord-301362-f3lp10lm	125	19	electron	electron	NN
cord-301362-f3lp10lm	125	20	microscopy	microscopy	NN
cord-301362-f3lp10lm	125	21	(	(	-LRB-
cord-301362-f3lp10lm	125	22	EM	EM	NNP
cord-301362-f3lp10lm	125	23	)	)	-RRB-
cord-301362-f3lp10lm	125	24	,	,	,
cord-301362-f3lp10lm	125	25	they	-PRON-	PRP
cord-301362-f3lp10lm	125	26	observed	observe	VBD
cord-301362-f3lp10lm	125	27	that	that	IN
cord-301362-f3lp10lm	125	28	the	the	DT
cord-301362-f3lp10lm	125	29	luminal	luminal	JJ
cord-301362-f3lp10lm	125	30	side	side	NN
cord-301362-f3lp10lm	125	31	of	of	IN
cord-301362-f3lp10lm	125	32	the	the	DT
cord-301362-f3lp10lm	125	33	spherule	spherule	NNP
cord-301362-f3lp10lm	125	34	was	be	VBD
cord-301362-f3lp10lm	125	35	linked	link	VBN
cord-301362-f3lp10lm	125	36	to	to	IN
cord-301362-f3lp10lm	125	37	the	the	DT
cord-301362-f3lp10lm	125	38	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	125	39	by	by	IN
cord-301362-f3lp10lm	125	40	a	a	DT
cord-301362-f3lp10lm	125	41	pore	pore	NN
cord-301362-f3lp10lm	125	42	from	from	IN
cord-301362-f3lp10lm	125	43	which	which	WDT
cord-301362-f3lp10lm	125	44	electron	electron	NN
cord-301362-f3lp10lm	125	45	-	-	HYPH
cord-301362-f3lp10lm	125	46	dense	dense	JJ
cord-301362-f3lp10lm	125	47	structures	structure	NNS
cord-301362-f3lp10lm	125	48	seems	seem	VBZ
cord-301362-f3lp10lm	125	49	to	to	TO
cord-301362-f3lp10lm	125	50	diffuse	diffuse	VB
cord-301362-f3lp10lm	125	51	to	to	IN
cord-301362-f3lp10lm	125	52	the	the	DT
cord-301362-f3lp10lm	125	53	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	126	1	(	(	-LRB-
cord-301362-f3lp10lm	126	2	Froshauer	Froshauer	NNP
cord-301362-f3lp10lm	126	3	et	et	NNP
cord-301362-f3lp10lm	126	4	al	al	NNP
cord-301362-f3lp10lm	126	5	.	.	NNP
cord-301362-f3lp10lm	126	6	,	,	,
cord-301362-f3lp10lm	126	7	1988	1988	CD
cord-301362-f3lp10lm	126	8	)	)	-RRB-
cord-301362-f3lp10lm	126	9	.	.	.
cord-301362-f3lp10lm	127	1	During	during	IN
cord-301362-f3lp10lm	127	2	the	the	DT
cord-301362-f3lp10lm	127	3	subsequent	subsequent	JJ
cord-301362-f3lp10lm	127	4	decades	decade	NNS
cord-301362-f3lp10lm	127	5	,	,	,
cord-301362-f3lp10lm	127	6	a	a	DT
cord-301362-f3lp10lm	127	7	great	great	JJ
cord-301362-f3lp10lm	127	8	amount	amount	NN
cord-301362-f3lp10lm	127	9	of	of	IN
cord-301362-f3lp10lm	127	10	effort	effort	NN
cord-301362-f3lp10lm	127	11	has	have	VBZ
cord-301362-f3lp10lm	127	12	been	be	VBN
cord-301362-f3lp10lm	127	13	done	do	VBN
cord-301362-f3lp10lm	127	14	to	to	TO
cord-301362-f3lp10lm	127	15	address	address	VB
cord-301362-f3lp10lm	127	16	the	the	DT
cord-301362-f3lp10lm	127	17	biogenesis	biogenesis	NN
cord-301362-f3lp10lm	127	18	and	and	CC
cord-301362-f3lp10lm	127	19	dynamics	dynamic	NNS
cord-301362-f3lp10lm	127	20	of	of	IN
cord-301362-f3lp10lm	127	21	the	the	DT
cord-301362-f3lp10lm	127	22	CPV	CPV	NNP
cord-301362-f3lp10lm	127	23	-	-	HYPH
cord-301362-f3lp10lm	127	24	I	i	NN
cord-301362-f3lp10lm	128	1	and	and	CC
cord-301362-f3lp10lm	128	2	,	,	,
cord-301362-f3lp10lm	128	3	nowadays	nowadays	RB
cord-301362-f3lp10lm	128	4	,	,	,
cord-301362-f3lp10lm	128	5	a	a	DT
cord-301362-f3lp10lm	128	6	whole	whole	JJ
cord-301362-f3lp10lm	128	7	picture	picture	NN
cord-301362-f3lp10lm	128	8	of	of	IN
cord-301362-f3lp10lm	128	9	the	the	DT
cord-301362-f3lp10lm	128	10	mechanism	mechanism	NN
cord-301362-f3lp10lm	128	11	involved	involve	VBN
cord-301362-f3lp10lm	128	12	in	in	IN
cord-301362-f3lp10lm	128	13	endosomal	endosomal	NNP
cord-301362-f3lp10lm	128	14	and	and	CC
cord-301362-f3lp10lm	128	15	lysosomal	lysosomal	JJ
cord-301362-f3lp10lm	128	16	membrane	membrane	NN
cord-301362-f3lp10lm	128	17	modification	modification	NN
cord-301362-f3lp10lm	128	18	by	by	IN
cord-301362-f3lp10lm	128	19	SFV	SFV	NNP
cord-301362-f3lp10lm	128	20	has	have	VBZ
cord-301362-f3lp10lm	128	21	been	be	VBN
cord-301362-f3lp10lm	128	22	nicely	nicely	RB
cord-301362-f3lp10lm	128	23	depicted	depict	VBN
cord-301362-f3lp10lm	128	24	.	.	.
cord-301362-f3lp10lm	129	1	The	the	DT
cord-301362-f3lp10lm	129	2	nsPs	nsps	NN
cord-301362-f3lp10lm	129	3	are	be	VBP
cord-301362-f3lp10lm	129	4	synthesized	synthesize	VBN
cord-301362-f3lp10lm	129	5	from	from	IN
cord-301362-f3lp10lm	129	6	the	the	DT
cord-301362-f3lp10lm	129	7	viral	viral	JJ
cord-301362-f3lp10lm	129	8	positive	positive	JJ
cord-301362-f3lp10lm	129	9	-	-	HYPH
cord-301362-f3lp10lm	129	10	sense	sense	NN
cord-301362-f3lp10lm	129	11	RNA	RNA	NNP
cord-301362-f3lp10lm	129	12	genome	genome	NN
cord-301362-f3lp10lm	129	13	as	as	IN
cord-301362-f3lp10lm	129	14	one	one	CD
cord-301362-f3lp10lm	129	15	polyprotein	polyprotein	NN
cord-301362-f3lp10lm	129	16	,	,	,
cord-301362-f3lp10lm	129	17	which	which	WDT
cord-301362-f3lp10lm	129	18	gives	give	VBZ
cord-301362-f3lp10lm	129	19	rise	rise	NN
cord-301362-f3lp10lm	129	20	to	to	IN
cord-301362-f3lp10lm	129	21	four	four	CD
cord-301362-f3lp10lm	129	22	nonstructural	nonstructural	JJ
cord-301362-f3lp10lm	129	23	proteins	protein	NNS
cord-301362-f3lp10lm	129	24	generated	generate	VBN
cord-301362-f3lp10lm	129	25	by	by	IN
cord-301362-f3lp10lm	129	26	cleavages	cleavage	NNS
cord-301362-f3lp10lm	129	27	catalyzed	catalyze	VBN
cord-301362-f3lp10lm	129	28	by	by	IN
cord-301362-f3lp10lm	129	29	nsP2	nsp2	NN
cord-301362-f3lp10lm	129	30	.	.	.
cord-301362-f3lp10lm	130	1	Of	of	IN
cord-301362-f3lp10lm	130	2	the	the	DT
cord-301362-f3lp10lm	130	3	four	four	CD
cord-301362-f3lp10lm	130	4	nsPs	nsps	NN
cord-301362-f3lp10lm	130	5	,	,	,
cord-301362-f3lp10lm	130	6	only	only	RB
cord-301362-f3lp10lm	130	7	nsP1	nsp1	NN
cord-301362-f3lp10lm	130	8	,	,	,
cord-301362-f3lp10lm	130	9	thanks	thank	NNS
cord-301362-f3lp10lm	130	10	to	to	IN
cord-301362-f3lp10lm	130	11	an	an	DT
cord-301362-f3lp10lm	130	12	amphipathic	amphipathic	JJ
cord-301362-f3lp10lm	130	13	helix	helix	NN
cord-301362-f3lp10lm	130	14	spotted	spot	VBN
cord-301362-f3lp10lm	130	15	in	in	IN
cord-301362-f3lp10lm	130	16	the	the	DT
cord-301362-f3lp10lm	130	17	central	central	JJ
cord-301362-f3lp10lm	130	18	part	part	NN
cord-301362-f3lp10lm	130	19	of	of	IN
cord-301362-f3lp10lm	130	20	the	the	DT
cord-301362-f3lp10lm	130	21	polypeptide	polypeptide	NN
cord-301362-f3lp10lm	130	22	,	,	,
cord-301362-f3lp10lm	130	23	is	be	VBZ
cord-301362-f3lp10lm	130	24	the	the	DT
cord-301362-f3lp10lm	130	25	only	only	JJ
cord-301362-f3lp10lm	130	26	non	non	JJ
cord-301362-f3lp10lm	130	27	-	-	JJ
cord-301362-f3lp10lm	130	28	structural	structural	JJ
cord-301362-f3lp10lm	130	29	protein	protein	NN
cord-301362-f3lp10lm	130	30	that	that	WDT
cord-301362-f3lp10lm	130	31	interacts	interact	VBZ
cord-301362-f3lp10lm	130	32	with	with	IN
cord-301362-f3lp10lm	130	33	membranes	membrane	NNS
cord-301362-f3lp10lm	130	34	(	(	-LRB-
cord-301362-f3lp10lm	130	35	Peranen	Peranen	NNP
cord-301362-f3lp10lm	130	36	et	et	NNP
cord-301362-f3lp10lm	130	37	al	al	NNP
cord-301362-f3lp10lm	130	38	.	.	NNP
cord-301362-f3lp10lm	130	39	,	,	,
cord-301362-f3lp10lm	130	40	1995	1995	CD
cord-301362-f3lp10lm	130	41	;	;	:
cord-301362-f3lp10lm	131	1	Ahola	Ahola	NNP
cord-301362-f3lp10lm	131	2	et	et	NNP
cord-301362-f3lp10lm	131	3	al	al	NNP
cord-301362-f3lp10lm	131	4	.	.	NNP
cord-301362-f3lp10lm	131	5	,	,	,
cord-301362-f3lp10lm	131	6	1999	1999	CD
cord-301362-f3lp10lm	131	7	;	;	:
cord-301362-f3lp10lm	131	8	Lampio	Lampio	NNP
cord-301362-f3lp10lm	131	9	et	et	NNP
cord-301362-f3lp10lm	131	10	al	al	NNP
cord-301362-f3lp10lm	131	11	.	.	NNP
cord-301362-f3lp10lm	131	12	,	,	,
cord-301362-f3lp10lm	131	13	2000	2000	CD
cord-301362-f3lp10lm	131	14	)	)	-RRB-
cord-301362-f3lp10lm	131	15	.	.	.
cord-301362-f3lp10lm	132	1	NsP1	nsp1	NN
cord-301362-f3lp10lm	132	2	has	have	VBZ
cord-301362-f3lp10lm	132	3	specific	specific	JJ
cord-301362-f3lp10lm	132	4	affinity	affinity	NN
cord-301362-f3lp10lm	132	5	for	for	IN
cord-301362-f3lp10lm	132	6	negatively	negatively	RB
cord-301362-f3lp10lm	132	7	charged	charge	VBN
cord-301362-f3lp10lm	132	8	phospholipids	phospholipid	NNS
cord-301362-f3lp10lm	132	9	explaining	explain	VBG
cord-301362-f3lp10lm	132	10	its	-PRON-	PRP$
cord-301362-f3lp10lm	132	11	predominant	predominant	JJ
cord-301362-f3lp10lm	132	12	localization	localization	NN
cord-301362-f3lp10lm	132	13	to	to	IN
cord-301362-f3lp10lm	132	14	plasma	plasma	NN
cord-301362-f3lp10lm	132	15	membrane	membrane	NN
cord-301362-f3lp10lm	132	16	(	(	-LRB-
cord-301362-f3lp10lm	132	17	PM	PM	NNP
cord-301362-f3lp10lm	132	18	)	)	-RRB-
cord-301362-f3lp10lm	132	19	,	,	,
cord-301362-f3lp10lm	132	20	where	where	WRB
cord-301362-f3lp10lm	132	21	those	those	DT
cord-301362-f3lp10lm	132	22	lipids	lipid	NNS
cord-301362-f3lp10lm	132	23	are	be	VBP
cord-301362-f3lp10lm	132	24	enriched	enrich	VBN
cord-301362-f3lp10lm	132	25	.	.	.
cord-301362-f3lp10lm	133	1	The	the	DT
cord-301362-f3lp10lm	133	2	membrane	membrane	NN
cord-301362-f3lp10lm	133	3	association	association	NN
cord-301362-f3lp10lm	133	4	of	of	IN
cord-301362-f3lp10lm	133	5	nsP1	nsP1	NNP
cord-301362-f3lp10lm	133	6	is	be	VBZ
cord-301362-f3lp10lm	133	7	mediated	mediate	VBN
cord-301362-f3lp10lm	133	8	through	through	IN
cord-301362-f3lp10lm	133	9	direct	direct	JJ
cord-301362-f3lp10lm	133	10	interaction	interaction	NN
cord-301362-f3lp10lm	133	11	of	of	IN
cord-301362-f3lp10lm	133	12	an	an	DT
cord-301362-f3lp10lm	133	13	amphipathic	amphipathic	JJ
cord-301362-f3lp10lm	133	14	helix	helix	NN
cord-301362-f3lp10lm	133	15	with	with	IN
cord-301362-f3lp10lm	133	16	anionic	anionic	JJ
cord-301362-f3lp10lm	133	17	phospholipids	phospholipid	NNS
cord-301362-f3lp10lm	133	18	and	and	CC
cord-301362-f3lp10lm	133	19	is	be	VBZ
cord-301362-f3lp10lm	133	20	increased	increase	VBN
cord-301362-f3lp10lm	133	21	by	by	IN
cord-301362-f3lp10lm	133	22	post	post	JJ
cord-301362-f3lp10lm	133	23	-	-	JJ
cord-301362-f3lp10lm	133	24	translational	translational	JJ
cord-301362-f3lp10lm	133	25	palmitoylation	palmitoylation	NN
cord-301362-f3lp10lm	133	26	of	of	IN
cord-301362-f3lp10lm	133	27	one	one	CD
cord-301362-f3lp10lm	133	28	to	to	IN
cord-301362-f3lp10lm	133	29	three	three	CD
cord-301362-f3lp10lm	133	30	cysteine	cysteine	NN
cord-301362-f3lp10lm	133	31	residues	residue	NNS
cord-301362-f3lp10lm	133	32	at	at	IN
cord-301362-f3lp10lm	133	33	positions	position	NNS
cord-301362-f3lp10lm	133	34	418	418	CD
cord-301362-f3lp10lm	133	35	-	-	SYM
cord-301362-f3lp10lm	133	36	420	420	CD
cord-301362-f3lp10lm	134	1	(	(	-LRB-
cord-301362-f3lp10lm	134	2	Laakkonen	Laakkonen	NNP
cord-301362-f3lp10lm	134	3	et	et	NNP
cord-301362-f3lp10lm	134	4	al	al	NNP
cord-301362-f3lp10lm	134	5	.	.	.
cord-301362-f3lp10lm	135	1	,	,	,
cord-301362-f3lp10lm	135	2	1996	1996	CD
cord-301362-f3lp10lm	135	3	;	;	:
cord-301362-f3lp10lm	135	4	Ahola	Ahola	NNP
cord-301362-f3lp10lm	135	5	et	et	NNP
cord-301362-f3lp10lm	135	6	al	al	NNP
cord-301362-f3lp10lm	135	7	.	.	NNP
cord-301362-f3lp10lm	135	8	,	,	,
cord-301362-f3lp10lm	135	9	1999	1999	CD
cord-301362-f3lp10lm	135	10	)	)	-RRB-
cord-301362-f3lp10lm	135	11	.	.	.
cord-301362-f3lp10lm	136	1	It	-PRON-	PRP
cord-301362-f3lp10lm	136	2	has	have	VBZ
cord-301362-f3lp10lm	136	3	recently	recently	RB
cord-301362-f3lp10lm	136	4	been	be	VBN
cord-301362-f3lp10lm	136	5	demonstrated	demonstrate	VBN
cord-301362-f3lp10lm	136	6	that	that	IN
cord-301362-f3lp10lm	136	7	nsP1	nsp1	NN
cord-301362-f3lp10lm	136	8	can	can	MD
cord-301362-f3lp10lm	136	9	only	only	RB
cord-301362-f3lp10lm	136	10	become	become	VB
cord-301362-f3lp10lm	136	11	palmitoylated	palmitoylated	JJ
cord-301362-f3lp10lm	136	12	after	after	IN
cord-301362-f3lp10lm	136	13	associating	associate	VBG
cord-301362-f3lp10lm	136	14	with	with	IN
cord-301362-f3lp10lm	136	15	membranes	membrane	NNS
cord-301362-f3lp10lm	136	16	via	via	IN
cord-301362-f3lp10lm	136	17	the	the	DT
cord-301362-f3lp10lm	136	18	amphipathic	amphipathic	NNP
cord-301362-f3lp10lm	136	19	peptide	peptide	NNP
cord-301362-f3lp10lm	136	20	and	and	CC
cord-301362-f3lp10lm	136	21	that	that	IN
cord-301362-f3lp10lm	136	22	this	this	DT
cord-301362-f3lp10lm	136	23	interaction	interaction	NN
cord-301362-f3lp10lm	136	24	is	be	VBZ
cord-301362-f3lp10lm	136	25	essential	essential	JJ
cord-301362-f3lp10lm	136	26	for	for	IN
cord-301362-f3lp10lm	136	27	virus	virus	NN
cord-301362-f3lp10lm	136	28	replication	replication	NN
cord-301362-f3lp10lm	136	29	(	(	-LRB-
cord-301362-f3lp10lm	136	30	Spuul	Spuul	NNP
cord-301362-f3lp10lm	136	31	et	et	NNP
cord-301362-f3lp10lm	136	32	al	al	NNP
cord-301362-f3lp10lm	136	33	.	.	NNP
cord-301362-f3lp10lm	136	34	,	,	,
cord-301362-f3lp10lm	136	35	2007	2007	CD
cord-301362-f3lp10lm	136	36	)	)	-RRB-
cord-301362-f3lp10lm	136	37	.	.	.
cord-301362-f3lp10lm	137	1	With	with	IN
cord-301362-f3lp10lm	137	2	the	the	DT
cord-301362-f3lp10lm	137	3	aim	aim	NN
cord-301362-f3lp10lm	137	4	of	of	IN
cord-301362-f3lp10lm	137	5	following	follow	VBG
cord-301362-f3lp10lm	137	6	the	the	DT
cord-301362-f3lp10lm	137	7	distribution	distribution	NN
cord-301362-f3lp10lm	137	8	of	of	IN
cord-301362-f3lp10lm	137	9	SFV	SFV	NNP
cord-301362-f3lp10lm	137	10	RCs	RCs	NNP
cord-301362-f3lp10lm	137	11	Spuul	Spuul	NNP
cord-301362-f3lp10lm	137	12	et	et	NNP
cord-301362-f3lp10lm	137	13	al	al	NNP
cord-301362-f3lp10lm	137	14	.	.	NNP
cord-301362-f3lp10lm	137	15	performed	perform	VBD
cord-301362-f3lp10lm	137	16	double	double	JJ
cord-301362-f3lp10lm	137	17	labeling	labeling	NN
cord-301362-f3lp10lm	137	18	and	and	CC
cord-301362-f3lp10lm	137	19	EM	EM	NNP
cord-301362-f3lp10lm	137	20	studies	study	NNS
cord-301362-f3lp10lm	137	21	in	in	IN
cord-301362-f3lp10lm	137	22	a	a	DT
cord-301362-f3lp10lm	137	23	time	time	NN
cord-301362-f3lp10lm	137	24	course	course	NN
cord-301362-f3lp10lm	137	25	infection	infection	NN
cord-301362-f3lp10lm	137	26	(	(	-LRB-
cord-301362-f3lp10lm	137	27	Spuul	Spuul	NNP
cord-301362-f3lp10lm	137	28	et	et	NNP
cord-301362-f3lp10lm	137	29	al	al	NNP
cord-301362-f3lp10lm	137	30	.	.	NNP
cord-301362-f3lp10lm	137	31	,	,	,
cord-301362-f3lp10lm	137	32	2010	2010	CD
cord-301362-f3lp10lm	137	33	)	)	-RRB-
cord-301362-f3lp10lm	137	34	.	.	.
cord-301362-f3lp10lm	138	1	The	the	DT
cord-301362-f3lp10lm	138	2	authors	author	NNS
cord-301362-f3lp10lm	138	3	discovered	discover	VBD
cord-301362-f3lp10lm	138	4	that	that	IN
cord-301362-f3lp10lm	138	5	the	the	DT
cord-301362-f3lp10lm	138	6	RCs	RCs	NNP
cord-301362-f3lp10lm	138	7	were	be	VBD
cord-301362-f3lp10lm	138	8	predominantly	predominantly	RB
cord-301362-f3lp10lm	138	9	at	at	IN
cord-301362-f3lp10lm	138	10	the	the	DT
cord-301362-f3lp10lm	138	11	PM	PM	NNP
cord-301362-f3lp10lm	138	12	where	where	WRB
cord-301362-f3lp10lm	138	13	numerous	numerous	JJ
cord-301362-f3lp10lm	138	14	typical	typical	JJ
cord-301362-f3lp10lm	138	15	spherules	spherule	NNS
cord-301362-f3lp10lm	138	16	on	on	IN
cord-301362-f3lp10lm	138	17	the	the	DT
cord-301362-f3lp10lm	138	18	cell	cell	NN
cord-301362-f3lp10lm	138	19	surface	surface	NN
cord-301362-f3lp10lm	138	20	were	be	VBD
cord-301362-f3lp10lm	138	21	observed	observe	VBN
cord-301362-f3lp10lm	138	22	starting	start	VBG
cord-301362-f3lp10lm	138	23	from	from	IN
cord-301362-f3lp10lm	138	24	1	1	CD
cord-301362-f3lp10lm	138	25	h	h	NN
cord-301362-f3lp10lm	138	26	post	post	NN
cord-301362-f3lp10lm	138	27	-	-	NN
cord-301362-f3lp10lm	138	28	infection	infection	JJ
cord-301362-f3lp10lm	138	29	(	(	-LRB-
cord-301362-f3lp10lm	138	30	p.i	p.i	NNP
cord-301362-f3lp10lm	138	31	.	.	NNP
cord-301362-f3lp10lm	138	32	)	)	-RRB-
cord-301362-f3lp10lm	138	33	,	,	,
cord-301362-f3lp10lm	138	34	demonstrating	demonstrate	VBG
cord-301362-f3lp10lm	138	35	that	that	IN
cord-301362-f3lp10lm	138	36	these	these	DT
cord-301362-f3lp10lm	138	37	structures	structure	NNS
cord-301362-f3lp10lm	138	38	were	be	VBD
cord-301362-f3lp10lm	138	39	forming	form	VBG
cord-301362-f3lp10lm	138	40	from	from	IN
cord-301362-f3lp10lm	138	41	the	the	DT
cord-301362-f3lp10lm	138	42	PM	pm	NN
cord-301362-f3lp10lm	138	43	.	.	.
cord-301362-f3lp10lm	139	1	From	from	IN
cord-301362-f3lp10lm	139	2	2	2	CD
cord-301362-f3lp10lm	139	3	to	to	IN
cord-301362-f3lp10lm	139	4	4	4	CD
cord-301362-f3lp10lm	139	5	h	h	NN
cord-301362-f3lp10lm	139	6	p.i	p.i	NNP
cord-301362-f3lp10lm	139	7	.	.	NNP
cord-301362-f3lp10lm	139	8	,	,	,
cord-301362-f3lp10lm	139	9	the	the	DT
cord-301362-f3lp10lm	139	10	RCs	RCs	NNP
cord-301362-f3lp10lm	139	11	components	component	NNS
cord-301362-f3lp10lm	139	12	were	be	VBD
cord-301362-f3lp10lm	139	13	localized	localize	VBN
cord-301362-f3lp10lm	139	14	to	to	IN
cord-301362-f3lp10lm	139	15	small	small	JJ
cord-301362-f3lp10lm	139	16	intracellular	intracellular	JJ
cord-301362-f3lp10lm	139	17	vesicles	vesicle	NNS
cord-301362-f3lp10lm	139	18	,	,	,
cord-301362-f3lp10lm	139	19	and	and	CC
cord-301362-f3lp10lm	139	20	then	then	RB
cord-301362-f3lp10lm	139	21	later	later	RB
cord-301362-f3lp10lm	139	22	in	in	IN
cord-301362-f3lp10lm	139	23	the	the	DT
cord-301362-f3lp10lm	139	24	infection	infection	NN
cord-301362-f3lp10lm	139	25	,	,	,
cord-301362-f3lp10lm	139	26	the	the	DT
cord-301362-f3lp10lm	139	27	dsRNA	dsrna	NN
cord-301362-f3lp10lm	139	28	localized	localize	VBN
cord-301362-f3lp10lm	139	29	to	to	IN
cord-301362-f3lp10lm	139	30	large	large	JJ
cord-301362-f3lp10lm	139	31	vacuoles	vacuole	NNS
cord-301362-f3lp10lm	139	32	in	in	IN
cord-301362-f3lp10lm	139	33	the	the	DT
cord-301362-f3lp10lm	139	34	perinuclear	perinuclear	NNP
cord-301362-f3lp10lm	139	35	area	area	NN
cord-301362-f3lp10lm	139	36	,	,	,
cord-301362-f3lp10lm	139	37	the	the	DT
cord-301362-f3lp10lm	139	38	so	so	RB
cord-301362-f3lp10lm	139	39	called	call	VBN
cord-301362-f3lp10lm	139	40	CPV	CPV	NNP
cord-301362-f3lp10lm	139	41	-	-	HYPH
cord-301362-f3lp10lm	139	42	I.	i.	NN
cord-301362-f3lp10lm	140	1	The	the	DT
cord-301362-f3lp10lm	140	2	authors	author	NNS
cord-301362-f3lp10lm	140	3	also	also	RB
cord-301362-f3lp10lm	140	4	observed	observe	VBD
cord-301362-f3lp10lm	140	5	that	that	IN
cord-301362-f3lp10lm	140	6	PMassociated	PMassociated	NNP
cord-301362-f3lp10lm	140	7	spherules	spherule	NNS
cord-301362-f3lp10lm	140	8	trafficking	traffic	VBG
cord-301362-f3lp10lm	140	9	was	be	VBD
cord-301362-f3lp10lm	140	10	strongly	strongly	RB
cord-301362-f3lp10lm	140	11	dependent	dependent	JJ
cord-301362-f3lp10lm	140	12	upon	upon	IN
cord-301362-f3lp10lm	140	13	the	the	DT
cord-301362-f3lp10lm	140	14	activity	activity	NN
cord-301362-f3lp10lm	140	15	of	of	IN
cord-301362-f3lp10lm	140	16	class	class	NN
cord-301362-f3lp10lm	140	17	I	-PRON-	PRP
cord-301362-f3lp10lm	140	18	phosphatidylinositol	phosphatidylinositol	VBP
cord-301362-f3lp10lm	140	19	3-kinase	3-kinase	CD
cord-301362-f3lp10lm	140	20	and	and	CC
cord-301362-f3lp10lm	140	21	a	a	DT
cord-301362-f3lp10lm	140	22	functional	functional	JJ
cord-301362-f3lp10lm	140	23	actin	actin	NN
cord-301362-f3lp10lm	140	24	-	-	HYPH
cord-301362-f3lp10lm	140	25	myosin	myosin	NN
cord-301362-f3lp10lm	140	26	network	network	NN
cord-301362-f3lp10lm	140	27	,	,	,
cord-301362-f3lp10lm	140	28	suggesting	suggest	VBG
cord-301362-f3lp10lm	140	29	that	that	IN
cord-301362-f3lp10lm	140	30	the	the	DT
cord-301362-f3lp10lm	140	31	spherules	spherule	NNS
cord-301362-f3lp10lm	140	32	were	be	VBD
cord-301362-f3lp10lm	140	33	an	an	DT
cord-301362-f3lp10lm	140	34	unusual	unusual	JJ
cord-301362-f3lp10lm	140	35	type	type	NN
cord-301362-f3lp10lm	140	36	of	of	IN
cord-301362-f3lp10lm	140	37	endocytic	endocytic	JJ
cord-301362-f3lp10lm	140	38	cargo	cargo	NN
cord-301362-f3lp10lm	140	39	(	(	-LRB-
cord-301362-f3lp10lm	140	40	Spuul	Spuul	NNP
cord-301362-f3lp10lm	140	41	et	et	NNP
cord-301362-f3lp10lm	140	42	al	al	NNP
cord-301362-f3lp10lm	140	43	.	.	NNP
cord-301362-f3lp10lm	140	44	,	,	,
cord-301362-f3lp10lm	140	45	2010	2010	CD
cord-301362-f3lp10lm	140	46	)	)	-RRB-
cord-301362-f3lp10lm	140	47	.	.	.
cord-301362-f3lp10lm	141	1	Related	relate	VBN
cord-301362-f3lp10lm	141	2	to	to	IN
cord-301362-f3lp10lm	141	3	this	this	DT
cord-301362-f3lp10lm	141	4	critical	critical	JJ
cord-301362-f3lp10lm	141	5	step	step	NN
cord-301362-f3lp10lm	141	6	,	,	,
cord-301362-f3lp10lm	141	7	these	these	DT
cord-301362-f3lp10lm	141	8	authors	author	NNS
cord-301362-f3lp10lm	141	9	,	,	,
cord-301362-f3lp10lm	141	10	together	together	RB
cord-301362-f3lp10lm	141	11	with	with	IN
cord-301362-f3lp10lm	141	12	others	other	NNS
cord-301362-f3lp10lm	141	13	,	,	,
cord-301362-f3lp10lm	141	14	have	have	VBP
cord-301362-f3lp10lm	141	15	previously	previously	RB
cord-301362-f3lp10lm	141	16	published	publish	VBN
cord-301362-f3lp10lm	141	17	,	,	,
cord-301362-f3lp10lm	141	18	employing	employ	VBG
cord-301362-f3lp10lm	141	19	EM	EM	NNP
cord-301362-f3lp10lm	141	20	,	,	,
cord-301362-f3lp10lm	141	21	the	the	DT
cord-301362-f3lp10lm	141	22	presence	presence	NN
cord-301362-f3lp10lm	141	23	of	of	IN
cord-301362-f3lp10lm	141	24	spherules	spherule	NNS
cord-301362-f3lp10lm	141	25	associated	associate	VBN
cord-301362-f3lp10lm	141	26	to	to	IN
cord-301362-f3lp10lm	141	27	PM	pm	NN
cord-301362-f3lp10lm	141	28	-	-	HYPH
cord-301362-f3lp10lm	141	29	derived	derive	VBN
cord-301362-f3lp10lm	141	30	vesicles	vesicle	NNS
cord-301362-f3lp10lm	141	31	morphologically	morphologically	RB
cord-301362-f3lp10lm	141	32	similar	similar	JJ
cord-301362-f3lp10lm	141	33	to	to	IN
cord-301362-f3lp10lm	141	34	endocytic	endocytic	JJ
cord-301362-f3lp10lm	141	35	vesicles	vesicle	NNS
cord-301362-f3lp10lm	141	36	at	at	IN
cord-301362-f3lp10lm	141	37	the	the	DT
cord-301362-f3lp10lm	141	38	stage	stage	NN
cord-301362-f3lp10lm	141	39	of	of	IN
cord-301362-f3lp10lm	141	40	internalization	internalization	NN
cord-301362-f3lp10lm	142	1	(	(	-LRB-
cord-301362-f3lp10lm	142	2	Froshauer	Froshauer	NNP
cord-301362-f3lp10lm	142	3	et	et	NNP
cord-301362-f3lp10lm	142	4	al	al	NNP
cord-301362-f3lp10lm	142	5	.	.	.
cord-301362-f3lp10lm	143	1	,	,	,
cord-301362-f3lp10lm	143	2	1988	1988	CD
cord-301362-f3lp10lm	143	3	;	;	:
cord-301362-f3lp10lm	143	4	Kujala	Kujala	NNP
cord-301362-f3lp10lm	143	5	et	et	NNP
cord-301362-f3lp10lm	143	6	al	al	NNP
cord-301362-f3lp10lm	143	7	.	.	NNP
cord-301362-f3lp10lm	143	8	,	,	,
cord-301362-f3lp10lm	143	9	2001	2001	CD
cord-301362-f3lp10lm	143	10	)	)	-RRB-
cord-301362-f3lp10lm	143	11	.	.	.
cord-301362-f3lp10lm	144	1	Employing	employ	VBG
cord-301362-f3lp10lm	144	2	a	a	DT
cord-301362-f3lp10lm	144	3	fluorescent	fluorescent	NN
cord-301362-f3lp10lm	144	4	recombinant	recombinant	JJ
cord-301362-f3lp10lm	144	5	SFV	sfv	NN
cord-301362-f3lp10lm	144	6	(	(	-LRB-
cord-301362-f3lp10lm	144	7	SFV	sfv	NN
cord-301362-f3lp10lm	144	8	-	-	HYPH
cord-301362-f3lp10lm	144	9	ZsG	ZsG	NNP
cord-301362-f3lp10lm	144	10	)	)	-RRB-
cord-301362-f3lp10lm	144	11	,	,	,
cord-301362-f3lp10lm	144	12	and	and	CC
cord-301362-f3lp10lm	144	13	LysoTracker	LysoTracker	NNP
cord-301362-f3lp10lm	144	14	stained	stain	VBN
cord-301362-f3lp10lm	144	15	cells	cell	NNS
cord-301362-f3lp10lm	144	16	,	,	,
cord-301362-f3lp10lm	144	17	Spuul	Spuul	NNP
cord-301362-f3lp10lm	144	18	et	et	NNP
cord-301362-f3lp10lm	144	19	al	al	NNP
cord-301362-f3lp10lm	144	20	.	.	NNP
cord-301362-f3lp10lm	144	21	observed	observe	VBD
cord-301362-f3lp10lm	144	22	that	that	IN
cord-301362-f3lp10lm	144	23	the	the	DT
cord-301362-f3lp10lm	144	24	spherules	spherule	NNS
cord-301362-f3lp10lm	144	25	were	be	VBD
cord-301362-f3lp10lm	144	26	internalized	internalize	VBN
cord-301362-f3lp10lm	144	27	from	from	IN
cord-301362-f3lp10lm	144	28	the	the	DT
cord-301362-f3lp10lm	144	29	PM	PM	NNP
cord-301362-f3lp10lm	144	30	in	in	IN
cord-301362-f3lp10lm	144	31	neutral	neutral	JJ
cord-301362-f3lp10lm	144	32	vesicles	vesicle	NNS
cord-301362-f3lp10lm	144	33	which	which	WDT
cord-301362-f3lp10lm	144	34	underwent	undergo	VBD
cord-301362-f3lp10lm	144	35	several	several	JJ
cord-301362-f3lp10lm	144	36	fusion	fusion	NN
cord-301362-f3lp10lm	144	37	events	event	NNS
cord-301362-f3lp10lm	144	38	to	to	TO
cord-301362-f3lp10lm	144	39	be	be	VB
cord-301362-f3lp10lm	144	40	delivered	deliver	VBN
cord-301362-f3lp10lm	144	41	,	,	,
cord-301362-f3lp10lm	144	42	via	via	IN
cord-301362-f3lp10lm	144	43	a	a	DT
cord-301362-f3lp10lm	144	44	microtubule	microtubule	NN
cord-301362-f3lp10lm	144	45	-	-	HYPH
cord-301362-f3lp10lm	144	46	based	base	VBN
cord-301362-f3lp10lm	144	47	transport	transport	NN
cord-301362-f3lp10lm	144	48	,	,	,
cord-301362-f3lp10lm	144	49	to	to	IN
cord-301362-f3lp10lm	144	50	larger	large	JJR
cord-301362-f3lp10lm	144	51	acidic	acidic	JJ
cord-301362-f3lp10lm	144	52	organelles	organelle	NNS
cord-301362-f3lp10lm	144	53	located	locate	VBN
cord-301362-f3lp10lm	144	54	in	in	IN
cord-301362-f3lp10lm	144	55	the	the	DT
cord-301362-f3lp10lm	144	56	perinuclear	perinuclear	NNP
cord-301362-f3lp10lm	144	57	area	area	NN
cord-301362-f3lp10lm	144	58	to	to	TO
cord-301362-f3lp10lm	144	59	generate	generate	VB
cord-301362-f3lp10lm	144	60	the	the	DT
cord-301362-f3lp10lm	144	61	final	final	JJ
cord-301362-f3lp10lm	144	62	stable	stable	JJ
cord-301362-f3lp10lm	144	63	and	and	CC
cord-301362-f3lp10lm	144	64	static	static	JJ
cord-301362-f3lp10lm	144	65	compartment	compartment	NN
cord-301362-f3lp10lm	144	66	CPV	cpv	NN
cord-301362-f3lp10lm	144	67	-	-	,
cord-301362-f3lp10lm	144	68	I	I	NNP
cord-301362-f3lp10lm	144	69	,	,	,
cord-301362-f3lp10lm	144	70	containing	contain	VBG
cord-301362-f3lp10lm	144	71	hundreds	hundred	NNS
cord-301362-f3lp10lm	144	72	of	of	IN
cord-301362-f3lp10lm	144	73	RCs	rc	NNS
cord-301362-f3lp10lm	144	74	on	on	IN
cord-301362-f3lp10lm	144	75	their	-PRON-	PRP$
cord-301362-f3lp10lm	144	76	surfaces	surface	NNS
cord-301362-f3lp10lm	144	77	.	.	.
cord-301362-f3lp10lm	145	1	The	the	DT
cord-301362-f3lp10lm	145	2	average	average	JJ
cord-301362-f3lp10lm	145	3	size	size	NN
cord-301362-f3lp10lm	145	4	of	of	IN
cord-301362-f3lp10lm	145	5	CPV	cpv	NN
cord-301362-f3lp10lm	145	6	-	-	:
cord-301362-f3lp10lm	145	7	I	-PRON-	PRP
cord-301362-f3lp10lm	145	8	reaches	reach	VBZ
cord-301362-f3lp10lm	145	9	2	2	CD
cord-301362-f3lp10lm	145	10	µm	µm	NN
cord-301362-f3lp10lm	145	11	at	at	IN
cord-301362-f3lp10lm	145	12	12	12	CD
cord-301362-f3lp10lm	145	13	h	h	NN
cord-301362-f3lp10lm	145	14	p.i	p.i	NNP
cord-301362-f3lp10lm	145	15	.	.	.
cord-301362-f3lp10lm	145	16	significantly	significantly	RB
cord-301362-f3lp10lm	145	17	exceeding	exceed	VBG
cord-301362-f3lp10lm	145	18	the	the	DT
cord-301362-f3lp10lm	145	19	sizes	size	NNS
cord-301362-f3lp10lm	145	20	of	of	IN
cord-301362-f3lp10lm	145	21	late	late	JJ
cord-301362-f3lp10lm	145	22	endosomes	endosome	NNS
cord-301362-f3lp10lm	145	23	and	and	CC
cord-301362-f3lp10lm	145	24	lysosomes	lysosome	NNS
cord-301362-f3lp10lm	145	25	in	in	IN
cord-301362-f3lp10lm	145	26	non	non	JJ
cord-301362-f3lp10lm	145	27	-	-	JJ
cord-301362-f3lp10lm	145	28	infected	infected	JJ
cord-301362-f3lp10lm	145	29	cells	cell	NNS
cord-301362-f3lp10lm	146	1	(	(	-LRB-
cord-301362-f3lp10lm	146	2	Luzio	Luzio	NNP
cord-301362-f3lp10lm	146	3	et	et	FW
cord-301362-f3lp10lm	146	4	al	al	NNP
cord-301362-f3lp10lm	146	5	.	.	NNP
cord-301362-f3lp10lm	146	6	,	,	,
cord-301362-f3lp10lm	146	7	2007	2007	CD
cord-301362-f3lp10lm	146	8	)	)	-RRB-
cord-301362-f3lp10lm	146	9	indicating	indicate	VBG
cord-301362-f3lp10lm	146	10	that	that	IN
cord-301362-f3lp10lm	146	11	alphaviruses	alphavirus	NNS
cord-301362-f3lp10lm	146	12	have	have	VBP
cord-301362-f3lp10lm	146	13	evolved	evolve	VBN
cord-301362-f3lp10lm	146	14	a	a	DT
cord-301362-f3lp10lm	146	15	mechanism	mechanism	NN
cord-301362-f3lp10lm	146	16	to	to	TO
cord-301362-f3lp10lm	146	17	generate	generate	VB
cord-301362-f3lp10lm	146	18	and	and	CC
cord-301362-f3lp10lm	146	19	stabilize	stabilize	VB
cord-301362-f3lp10lm	146	20	membranes	membrane	NNS
cord-301362-f3lp10lm	146	21	of	of	IN
cord-301362-f3lp10lm	146	22	the	the	DT
cord-301362-f3lp10lm	146	23	endolysosomal	endolysosomal	JJ
cord-301362-f3lp10lm	146	24	compartment	compartment	NN
cord-301362-f3lp10lm	146	25	for	for	IN
cord-301362-f3lp10lm	146	26	their	-PRON-	PRP$
cord-301362-f3lp10lm	146	27	replication	replication	NN
cord-301362-f3lp10lm	146	28	.	.	.
cord-301362-f3lp10lm	147	1	A	a	DT
cord-301362-f3lp10lm	147	2	nice	nice	JJ
cord-301362-f3lp10lm	147	3	graphic	graphic	NN
cord-301362-f3lp10lm	147	4	schematizing	schematize	VBG
cord-301362-f3lp10lm	147	5	a	a	DT
cord-301362-f3lp10lm	147	6	model	model	NN
cord-301362-f3lp10lm	147	7	for	for	IN
cord-301362-f3lp10lm	147	8	the	the	DT
cord-301362-f3lp10lm	147	9	alphavirus	alphavirus	NNP
cord-301362-f3lp10lm	147	10	RCs	RCs	NNP
cord-301362-f3lp10lm	147	11	trafficking	trafficking	NN
cord-301362-f3lp10lm	147	12	and	and	CC
cord-301362-f3lp10lm	147	13	biogenesis	biogenesis	NN
cord-301362-f3lp10lm	147	14	of	of	IN
cord-301362-f3lp10lm	147	15	CPV	CPV	NNP
cord-301362-f3lp10lm	147	16	-	-	:
cord-301362-f3lp10lm	147	17	I	-PRON-	PRP
cord-301362-f3lp10lm	147	18	has	have	VBZ
cord-301362-f3lp10lm	147	19	been	be	VBN
cord-301362-f3lp10lm	147	20	depicted	depict	VBN
cord-301362-f3lp10lm	147	21	by	by	IN
cord-301362-f3lp10lm	147	22	Spuul	Spuul	NNP
cord-301362-f3lp10lm	147	23	et	et	NNP
cord-301362-f3lp10lm	147	24	al	al	NNP
cord-301362-f3lp10lm	147	25	.	.	.
cord-301362-f3lp10lm	148	1	(	(	-LRB-
cord-301362-f3lp10lm	148	2	2010	2010	CD
cord-301362-f3lp10lm	148	3	)	)	-RRB-
cord-301362-f3lp10lm	148	4	.	.	.
cord-301362-f3lp10lm	149	1	Members	member	NNS
cord-301362-f3lp10lm	149	2	of	of	IN
cord-301362-f3lp10lm	149	3	the	the	DT
cord-301362-f3lp10lm	149	4	Togaviridae	Togaviridae	NNP
cord-301362-f3lp10lm	149	5	family	family	NN
cord-301362-f3lp10lm	149	6	,	,	,
cord-301362-f3lp10lm	149	7	as	as	IN
cord-301362-f3lp10lm	149	8	mentioned	mention	VBN
cord-301362-f3lp10lm	149	9	above	above	RB
cord-301362-f3lp10lm	149	10	,	,	,
cord-301362-f3lp10lm	149	11	induce	induce	VB
cord-301362-f3lp10lm	149	12	viral	viral	JJ
cord-301362-f3lp10lm	149	13	replication	replication	NN
cord-301362-f3lp10lm	149	14	factories	factory	NNS
cord-301362-f3lp10lm	149	15	with	with	IN
cord-301362-f3lp10lm	149	16	spherule	spherule	NNP
cord-301362-f3lp10lm	149	17	morphology	morphology	NN
cord-301362-f3lp10lm	149	18	usurping	usurp	VBG
cord-301362-f3lp10lm	149	19	the	the	DT
cord-301362-f3lp10lm	149	20	endosomal	endosomal	NNP
cord-301362-f3lp10lm	149	21	and	and	CC
cord-301362-f3lp10lm	149	22	lysosomal	lysosomal	JJ
cord-301362-f3lp10lm	149	23	pathway	pathway	NN
cord-301362-f3lp10lm	149	24	from	from	IN
cord-301362-f3lp10lm	149	25	the	the	DT
cord-301362-f3lp10lm	149	26	cell	cell	NN
cord-301362-f3lp10lm	149	27	.	.	.
cord-301362-f3lp10lm	150	1	Even	even	RB
cord-301362-f3lp10lm	150	2	though	though	IN
cord-301362-f3lp10lm	150	3	no	no	DT
cord-301362-f3lp10lm	150	4	3-D	3-d	JJ
cord-301362-f3lp10lm	150	5	reconstruction	reconstruction	NN
cord-301362-f3lp10lm	150	6	of	of	IN
cord-301362-f3lp10lm	150	7	an	an	DT
cord-301362-f3lp10lm	150	8	alphavirus	alphavirus	NNP
cord-301362-f3lp10lm	150	9	replication	replication	NN
cord-301362-f3lp10lm	150	10	niche	niche	NN
cord-301362-f3lp10lm	150	11	has	have	VBZ
cord-301362-f3lp10lm	150	12	been	be	VBN
cord-301362-f3lp10lm	150	13	published	publish	VBN
cord-301362-f3lp10lm	150	14	to	to	IN
cord-301362-f3lp10lm	150	15	date	date	NN
cord-301362-f3lp10lm	150	16	,	,	,
cord-301362-f3lp10lm	150	17	spherule	spherule	JJ
cord-301362-f3lp10lm	150	18	structures	structure	NNS
cord-301362-f3lp10lm	150	19	associated	associate	VBN
cord-301362-f3lp10lm	150	20	to	to	IN
cord-301362-f3lp10lm	150	21	virus	virus	NN
cord-301362-f3lp10lm	150	22	replication	replication	NN
cord-301362-f3lp10lm	150	23	has	have	VBZ
cord-301362-f3lp10lm	150	24	been	be	VBN
cord-301362-f3lp10lm	150	25	nicely	nicely	RB
cord-301362-f3lp10lm	150	26	described	describe	VBN
cord-301362-f3lp10lm	150	27	for	for	IN
cord-301362-f3lp10lm	150	28	Sindbis	Sindbis	NNP
cord-301362-f3lp10lm	150	29	Virus	Virus	NNP
cord-301362-f3lp10lm	150	30	(	(	-LRB-
cord-301362-f3lp10lm	150	31	Frolova	Frolova	NNP
cord-301362-f3lp10lm	150	32	et	et	FW
cord-301362-f3lp10lm	150	33	al	al	NNP
cord-301362-f3lp10lm	150	34	.	.	NNP
cord-301362-f3lp10lm	150	35	,	,	,
cord-301362-f3lp10lm	150	36	2010	2010	CD
cord-301362-f3lp10lm	150	37	)	)	-RRB-
cord-301362-f3lp10lm	150	38	and	and	CC
cord-301362-f3lp10lm	150	39	Rubella	Rubella	NNP
cord-301362-f3lp10lm	150	40	virus	virus	NN
cord-301362-f3lp10lm	150	41	(	(	-LRB-
cord-301362-f3lp10lm	150	42	Fontana	Fontana	NNP
cord-301362-f3lp10lm	150	43	et	et	NNP
cord-301362-f3lp10lm	150	44	al	al	NNP
cord-301362-f3lp10lm	150	45	.	.	NNP
cord-301362-f3lp10lm	150	46	,	,	,
cord-301362-f3lp10lm	150	47	2010	2010	CD
cord-301362-f3lp10lm	150	48	)	)	-RRB-
cord-301362-f3lp10lm	150	49	,	,	,
cord-301362-f3lp10lm	150	50	in	in	IN
cord-301362-f3lp10lm	150	51	addition	addition	NN
cord-301362-f3lp10lm	150	52	to	to	IN
cord-301362-f3lp10lm	150	53	SFV	SFV	NNP
cord-301362-f3lp10lm	150	54	.	.	.
cord-301362-f3lp10lm	151	1	The	the	DT
cord-301362-f3lp10lm	151	2	first	first	JJ
cord-301362-f3lp10lm	151	3	3-D	3-d	JJ
cord-301362-f3lp10lm	151	4	reconstruction	reconstruction	NN
cord-301362-f3lp10lm	151	5	coming	come	VBG
cord-301362-f3lp10lm	151	6	from	from	IN
cord-301362-f3lp10lm	151	7	a	a	DT
cord-301362-f3lp10lm	151	8	+	+	``
cord-301362-f3lp10lm	151	9	sRNA	srna	JJ
cord-301362-f3lp10lm	151	10	viral	viral	JJ
cord-301362-f3lp10lm	151	11	replication	replication	NN
cord-301362-f3lp10lm	151	12	niche	niche	NN
cord-301362-f3lp10lm	151	13	was	be	VBD
cord-301362-f3lp10lm	151	14	published	publish	VBN
cord-301362-f3lp10lm	151	15	by	by	IN
cord-301362-f3lp10lm	151	16	Kopek	Kopek	NNP
cord-301362-f3lp10lm	151	17	et	et	NNP
cord-301362-f3lp10lm	151	18	al	al	NNP
cord-301362-f3lp10lm	151	19	.	.	.
cord-301362-f3lp10lm	152	1	(	(	-LRB-
cord-301362-f3lp10lm	152	2	2007	2007	CD
cord-301362-f3lp10lm	152	3	)	)	-RRB-
cord-301362-f3lp10lm	152	4	.	.	.
cord-301362-f3lp10lm	153	1	Electron	electron	NN
cord-301362-f3lp10lm	153	2	tomography	tomography	NN
cord-301362-f3lp10lm	153	3	of	of	IN
cord-301362-f3lp10lm	153	4	Flock	Flock	NNP
cord-301362-f3lp10lm	153	5	House	House	NNP
cord-301362-f3lp10lm	153	6	Virus	Virus	NNP
cord-301362-f3lp10lm	153	7	(	(	-LRB-
cord-301362-f3lp10lm	153	8	FHV)-infected	fhv)-infecte	VBN
cord-301362-f3lp10lm	153	9	cells	cell	NNS
cord-301362-f3lp10lm	153	10	uncovered	uncover	VBD
cord-301362-f3lp10lm	153	11	invaginations	invagination	NNS
cord-301362-f3lp10lm	153	12	or	or	CC
cord-301362-f3lp10lm	153	13	spherules	spherule	NNS
cord-301362-f3lp10lm	153	14	on	on	IN
cord-301362-f3lp10lm	153	15	the	the	DT
cord-301362-f3lp10lm	153	16	external	external	JJ
cord-301362-f3lp10lm	153	17	mitochondrial	mitochondrial	NN
cord-301362-f3lp10lm	153	18	membrane	membrane	NN
cord-301362-f3lp10lm	153	19	(	(	-LRB-
cord-301362-f3lp10lm	153	20	OMM	OMM	NNP
cord-301362-f3lp10lm	153	21	)	)	-RRB-
cord-301362-f3lp10lm	153	22	.	.	.
cord-301362-f3lp10lm	154	1	Similar	similar	JJ
cord-301362-f3lp10lm	154	2	to	to	IN
cord-301362-f3lp10lm	154	3	alphaviruses	alphaviruses	NNP
cord-301362-f3lp10lm	154	4	,	,	,
cord-301362-f3lp10lm	154	5	the	the	DT
cord-301362-f3lp10lm	154	6	spherules	spherule	NNS
cord-301362-f3lp10lm	154	7	detected	detect	VBD
cord-301362-f3lp10lm	154	8	in	in	IN
cord-301362-f3lp10lm	154	9	FHV	FHV	NNP
cord-301362-f3lp10lm	154	10	-	-	HYPH
cord-301362-f3lp10lm	154	11	infected	infect	VBN
cord-301362-f3lp10lm	154	12	cells	cell	NNS
cord-301362-f3lp10lm	154	13	were	be	VBD
cord-301362-f3lp10lm	154	14	about	about	RB
cord-301362-f3lp10lm	154	15	50	50	CD
cord-301362-f3lp10lm	154	16	nm	nm	NN
cord-301362-f3lp10lm	154	17	in	in	IN
cord-301362-f3lp10lm	154	18	diameter	diameter	NN
cord-301362-f3lp10lm	155	1	(	(	-LRB-
cord-301362-f3lp10lm	155	2	Miller	Miller	NNP
cord-301362-f3lp10lm	155	3	et	et	NNP
cord-301362-f3lp10lm	155	4	al	al	NNP
cord-301362-f3lp10lm	155	5	.	.	NNP
cord-301362-f3lp10lm	155	6	,	,	,
cord-301362-f3lp10lm	155	7	2001	2001	CD
cord-301362-f3lp10lm	155	8	)	)	-RRB-
cord-301362-f3lp10lm	155	9	and	and	CC
cord-301362-f3lp10lm	155	10	contains	contain	VBZ
cord-301362-f3lp10lm	155	11	a	a	DT
cord-301362-f3lp10lm	155	12	membranous	membranous	JJ
cord-301362-f3lp10lm	155	13	neck	neck	NN
cord-301362-f3lp10lm	155	14	with	with	IN
cord-301362-f3lp10lm	155	15	an	an	DT
cord-301362-f3lp10lm	155	16	internal	internal	JJ
cord-301362-f3lp10lm	155	17	diameter	diameter	NN
cord-301362-f3lp10lm	155	18	of	of	IN
cord-301362-f3lp10lm	155	19	around	around	RB
cord-301362-f3lp10lm	155	20	10	10	CD
cord-301362-f3lp10lm	155	21	nm	nm	NN
cord-301362-f3lp10lm	155	22	connecting	connect	VBG
cord-301362-f3lp10lm	155	23	the	the	DT
cord-301362-f3lp10lm	155	24	spherule	spherule	JJ
cord-301362-f3lp10lm	155	25	lumen	lumen	NN
cord-301362-f3lp10lm	155	26	with	with	IN
cord-301362-f3lp10lm	155	27	the	the	DT
cord-301362-f3lp10lm	155	28	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	156	1	(	(	-LRB-
cord-301362-f3lp10lm	156	2	Kopek	Kopek	NNP
cord-301362-f3lp10lm	156	3	et	et	FW
cord-301362-f3lp10lm	156	4	al	al	NNP
cord-301362-f3lp10lm	156	5	.	.	NNP
cord-301362-f3lp10lm	156	6	,	,	,
cord-301362-f3lp10lm	156	7	2007	2007	CD
cord-301362-f3lp10lm	156	8	)	)	-RRB-
cord-301362-f3lp10lm	156	9	.	.	.
cord-301362-f3lp10lm	157	1	Contrary	contrary	JJ
cord-301362-f3lp10lm	157	2	to	to	IN
cord-301362-f3lp10lm	157	3	the	the	DT
cord-301362-f3lp10lm	157	4	replication	replication	NN
cord-301362-f3lp10lm	157	5	niches	niche	NNS
cord-301362-f3lp10lm	157	6	of	of	IN
cord-301362-f3lp10lm	157	7	these	these	DT
cord-301362-f3lp10lm	157	8	+	+	SYM
cord-301362-f3lp10lm	157	9	sRNA	srna	NN
cord-301362-f3lp10lm	157	10	viruses	virus	NNS
cord-301362-f3lp10lm	157	11	,	,	,
cord-301362-f3lp10lm	157	12	replication	replication	NN
cord-301362-f3lp10lm	157	13	factories	factory	NNS
cord-301362-f3lp10lm	157	14	of	of	IN
cord-301362-f3lp10lm	157	15	two	two	CD
cord-301362-f3lp10lm	157	16	members	member	NNS
cord-301362-f3lp10lm	157	17	of	of	IN
cord-301362-f3lp10lm	157	18	the	the	DT
cord-301362-f3lp10lm	157	19	Flaviviridae	Flaviviridae	NNP
cord-301362-f3lp10lm	157	20	family	family	NN
cord-301362-f3lp10lm	157	21	,	,	,
cord-301362-f3lp10lm	157	22	West	West	NNP
cord-301362-f3lp10lm	157	23	Nile	Nile	NNP
cord-301362-f3lp10lm	157	24	Virus	Virus	NNP
cord-301362-f3lp10lm	157	25	(	(	-LRB-
cord-301362-f3lp10lm	157	26	WNV	WNV	NNP
cord-301362-f3lp10lm	157	27	)	)	-RRB-
cord-301362-f3lp10lm	157	28	and	and	CC
cord-301362-f3lp10lm	157	29	Dengue	Dengue	NNP
cord-301362-f3lp10lm	157	30	Virus	Virus	NNP
cord-301362-f3lp10lm	157	31	(	(	-LRB-
cord-301362-f3lp10lm	157	32	DENV	DENV	NNP
cord-301362-f3lp10lm	157	33	)	)	-RRB-
cord-301362-f3lp10lm	157	34	,	,	,
cord-301362-f3lp10lm	157	35	are	be	VBP
cord-301362-f3lp10lm	157	36	derived	derive	VBN
cord-301362-f3lp10lm	157	37	from	from	IN
cord-301362-f3lp10lm	157	38	the	the	DT
cord-301362-f3lp10lm	157	39	endoplasmic	endoplasmic	NN
cord-301362-f3lp10lm	157	40	reticulum	reticulum	NN
cord-301362-f3lp10lm	157	41	(	(	-LRB-
cord-301362-f3lp10lm	157	42	ER	ER	NNP
cord-301362-f3lp10lm	157	43	)	)	-RRB-
cord-301362-f3lp10lm	157	44	.	.	.
cord-301362-f3lp10lm	158	1	Recently	recently	RB
cord-301362-f3lp10lm	158	2	,	,	,
cord-301362-f3lp10lm	158	3	Welsch	Welsch	NNP
cord-301362-f3lp10lm	158	4	et	et	NNP
cord-301362-f3lp10lm	158	5	al	al	NNP
cord-301362-f3lp10lm	158	6	.	.	NNP
cord-301362-f3lp10lm	158	7	reported	report	VBD
cord-301362-f3lp10lm	158	8	a	a	DT
cord-301362-f3lp10lm	158	9	detailed	detailed	JJ
cord-301362-f3lp10lm	158	10	study	study	NN
cord-301362-f3lp10lm	158	11	deciphering	decipher	VBG
cord-301362-f3lp10lm	158	12	the	the	DT
cord-301362-f3lp10lm	158	13	3-D	3-d	JJ
cord-301362-f3lp10lm	158	14	architecture	architecture	NN
cord-301362-f3lp10lm	158	15	of	of	IN
cord-301362-f3lp10lm	158	16	virus	virus	NN
cord-301362-f3lp10lm	158	17	-	-	HYPH
cord-301362-f3lp10lm	158	18	induced	induce	VBN
cord-301362-f3lp10lm	158	19	membrane	membrane	NN
cord-301362-f3lp10lm	158	20	rearrangements	rearrangement	NNS
cord-301362-f3lp10lm	158	21	involved	involve	VBN
cord-301362-f3lp10lm	158	22	in	in	IN
cord-301362-f3lp10lm	158	23	DENV	DENV	NNP
cord-301362-f3lp10lm	158	24	replication	replication	NN
cord-301362-f3lp10lm	158	25	(	(	-LRB-
cord-301362-f3lp10lm	158	26	Welsch	Welsch	NNP
cord-301362-f3lp10lm	158	27	et	et	NNP
cord-301362-f3lp10lm	158	28	al	al	NNP
cord-301362-f3lp10lm	158	29	.	.	NNP
cord-301362-f3lp10lm	158	30	,	,	,
cord-301362-f3lp10lm	158	31	2009	2009	CD
cord-301362-f3lp10lm	158	32	)	)	-RRB-
cord-301362-f3lp10lm	158	33	.	.	.
cord-301362-f3lp10lm	159	1	The	the	DT
cord-301362-f3lp10lm	159	2	authors	author	NNS
cord-301362-f3lp10lm	159	3	employed	employ	VBD
cord-301362-f3lp10lm	159	4	several	several	JJ
cord-301362-f3lp10lm	159	5	EM	EM	NNP
cord-301362-f3lp10lm	159	6	techniques	technique	NNS
cord-301362-f3lp10lm	159	7	including	include	VBG
cord-301362-f3lp10lm	159	8	electron	electron	NN
cord-301362-f3lp10lm	159	9	tomography	tomography	NN
cord-301362-f3lp10lm	159	10	(	(	-LRB-
cord-301362-f3lp10lm	159	11	ET	et	NN
cord-301362-f3lp10lm	159	12	)	)	-RRB-
cord-301362-f3lp10lm	159	13	to	to	TO
cord-301362-f3lp10lm	159	14	obtain	obtain	VB
cord-301362-f3lp10lm	159	15	the	the	DT
cord-301362-f3lp10lm	159	16	3-D	3-d	JJ
cord-301362-f3lp10lm	159	17	analysis	analysis	NN
cord-301362-f3lp10lm	159	18	of	of	IN
cord-301362-f3lp10lm	159	19	the	the	DT
cord-301362-f3lp10lm	159	20	virus	virus	NN
cord-301362-f3lp10lm	159	21	-	-	HYPH
cord-301362-f3lp10lm	159	22	induced	induce	VBN
cord-301362-f3lp10lm	159	23	vesicles	vesicle	NNS
cord-301362-f3lp10lm	159	24	revealing	reveal	VBG
cord-301362-f3lp10lm	159	25	that	that	IN
cord-301362-f3lp10lm	159	26	they	-PRON-	PRP
cord-301362-f3lp10lm	159	27	are	be	VBP
cord-301362-f3lp10lm	159	28	invaginations	invagination	NNS
cord-301362-f3lp10lm	159	29	of	of	IN
cord-301362-f3lp10lm	159	30	the	the	DT
cord-301362-f3lp10lm	159	31	ER	ER	NNP
cord-301362-f3lp10lm	159	32	membrane	membrane	NN
cord-301362-f3lp10lm	159	33	,	,	,
cord-301362-f3lp10lm	159	34	connected	connect	VBN
cord-301362-f3lp10lm	159	35	to	to	IN
cord-301362-f3lp10lm	159	36	the	the	DT
cord-301362-f3lp10lm	159	37	cytosol	cytosol	NN
cord-301362-f3lp10lm	159	38	through	through	IN
cord-301362-f3lp10lm	159	39	a	a	DT
cord-301362-f3lp10lm	159	40	pore	pore	NN
cord-301362-f3lp10lm	159	41	that	that	WDT
cord-301362-f3lp10lm	159	42	may	may	MD
cord-301362-f3lp10lm	159	43	regulate	regulate	VB
cord-301362-f3lp10lm	159	44	import	import	NN
cord-301362-f3lp10lm	159	45	of	of	IN
cord-301362-f3lp10lm	159	46	factors	factor	NNS
cord-301362-f3lp10lm	159	47	required	require	VBN
cord-301362-f3lp10lm	159	48	for	for	IN
cord-301362-f3lp10lm	159	49	RNA	RNA	NNP
cord-301362-f3lp10lm	159	50	replication	replication	NN
cord-301362-f3lp10lm	159	51	as	as	RB
cord-301362-f3lp10lm	159	52	well	well	RB
cord-301362-f3lp10lm	159	53	as	as	IN
cord-301362-f3lp10lm	159	54	export	export	NN
cord-301362-f3lp10lm	159	55	of	of	IN
cord-301362-f3lp10lm	159	56	newly	newly	RB
cord-301362-f3lp10lm	159	57	synthesized	synthesize	VBN
cord-301362-f3lp10lm	159	58	genomes	genome	NNS
cord-301362-f3lp10lm	159	59	to	to	TO
cord-301362-f3lp10lm	159	60	be	be	VB
cord-301362-f3lp10lm	159	61	used	use	VBN
cord-301362-f3lp10lm	159	62	for	for	IN
cord-301362-f3lp10lm	159	63	translation	translation	NN
cord-301362-f3lp10lm	159	64	or	or	CC
cord-301362-f3lp10lm	159	65	virus	virus	NN
cord-301362-f3lp10lm	159	66	assembly	assembly	NN
cord-301362-f3lp10lm	159	67	.	.	.
cord-301362-f3lp10lm	160	1	Additionally	additionally	RB
cord-301362-f3lp10lm	160	2	,	,	,
cord-301362-f3lp10lm	160	3	and	and	CC
cord-301362-f3lp10lm	160	4	thanks	thank	NNS
cord-301362-f3lp10lm	160	5	to	to	IN
cord-301362-f3lp10lm	160	6	the	the	DT
cord-301362-f3lp10lm	160	7	powerful	powerful	JJ
cord-301362-f3lp10lm	160	8	ET	ET	NNP
cord-301362-f3lp10lm	160	9	technique	technique	NN
cord-301362-f3lp10lm	160	10	,	,	,
cord-301362-f3lp10lm	160	11	the	the	DT
cord-301362-f3lp10lm	160	12	authors	author	NNS
cord-301362-f3lp10lm	160	13	demonstrated	demonstrate	VBD
cord-301362-f3lp10lm	160	14	the	the	DT
cord-301362-f3lp10lm	160	15	presence	presence	NN
cord-301362-f3lp10lm	160	16	of	of	IN
cord-301362-f3lp10lm	160	17	virus	virus	NN
cord-301362-f3lp10lm	160	18	budding	bud	VBG
cord-301362-f3lp10lm	160	19	sites	site	NNS
cord-301362-f3lp10lm	160	20	in	in	IN
cord-301362-f3lp10lm	160	21	close	close	JJ
cord-301362-f3lp10lm	160	22	proximity	proximity	NN
cord-301362-f3lp10lm	160	23	to	to	IN
cord-301362-f3lp10lm	160	24	the	the	DT
cord-301362-f3lp10lm	160	25	pores	pore	NNS
cord-301362-f3lp10lm	160	26	of	of	IN
cord-301362-f3lp10lm	160	27	replication	replication	NN
cord-301362-f3lp10lm	160	28	vesicles	vesicle	NNS
cord-301362-f3lp10lm	160	29	,	,	,
cord-301362-f3lp10lm	160	30	providing	provide	VBG
cord-301362-f3lp10lm	160	31	for	for	IN
cord-301362-f3lp10lm	160	32	the	the	DT
cord-301362-f3lp10lm	160	33	first	first	JJ
cord-301362-f3lp10lm	160	34	time	time	NN
cord-301362-f3lp10lm	160	35	a	a	DT
cord-301362-f3lp10lm	160	36	direct	direct	JJ
cord-301362-f3lp10lm	160	37	visualization	visualization	NN
cord-301362-f3lp10lm	160	38	,	,	,
cord-301362-f3lp10lm	160	39	in	in	IN
cord-301362-f3lp10lm	160	40	3D	3D	NNP
cord-301362-f3lp10lm	160	41	,	,	,
cord-301362-f3lp10lm	160	42	of	of	IN
cord-301362-f3lp10lm	160	43	this	this	DT
cord-301362-f3lp10lm	160	44	process	process	NN
cord-301362-f3lp10lm	160	45	(	(	-LRB-
cord-301362-f3lp10lm	160	46	Welsch	Welsch	NNP
cord-301362-f3lp10lm	160	47	et	et	NNP
cord-301362-f3lp10lm	160	48	al	al	NNP
cord-301362-f3lp10lm	160	49	.	.	NNP
cord-301362-f3lp10lm	160	50	,	,	,
cord-301362-f3lp10lm	160	51	2009	2009	CD
cord-301362-f3lp10lm	160	52	)	)	-RRB-
cord-301362-f3lp10lm	160	53	.	.	.
cord-301362-f3lp10lm	161	1	Vesicle	Vesicle	NNP
cord-301362-f3lp10lm	161	2	formation	formation	NN
cord-301362-f3lp10lm	161	3	is	be	VBZ
cord-301362-f3lp10lm	161	4	probably	probably	RB
cord-301362-f3lp10lm	161	5	induced	induce	VBN
cord-301362-f3lp10lm	161	6	by	by	IN
cord-301362-f3lp10lm	161	7	the	the	DT
cord-301362-f3lp10lm	161	8	non	non	JJ
cord-301362-f3lp10lm	161	9	-	-	JJ
cord-301362-f3lp10lm	161	10	structural	structural	JJ
cord-301362-f3lp10lm	161	11	protein	protein	NN
cord-301362-f3lp10lm	161	12	4A	4a	CD
cord-301362-f3lp10lm	161	13	(	(	-LRB-
cord-301362-f3lp10lm	161	14	NS4A	NS4A	NNP
cord-301362-f3lp10lm	161	15	)	)	-RRB-
cord-301362-f3lp10lm	161	16	,	,	,
cord-301362-f3lp10lm	161	17	which	which	WDT
cord-301362-f3lp10lm	161	18	appears	appear	VBZ
cord-301362-f3lp10lm	161	19	to	to	TO
cord-301362-f3lp10lm	161	20	contain	contain	VB
cord-301362-f3lp10lm	161	21	a	a	DT
cord-301362-f3lp10lm	161	22	central	central	JJ
cord-301362-f3lp10lm	161	23	peripheral	peripheral	JJ
cord-301362-f3lp10lm	161	24	membrane	membrane	NN
cord-301362-f3lp10lm	161	25	domain	domain	NN
cord-301362-f3lp10lm	161	26	that	that	WDT
cord-301362-f3lp10lm	161	27	intercalates	intercalate	VBZ
cord-301362-f3lp10lm	161	28	into	into	IN
cord-301362-f3lp10lm	161	29	the	the	DT
cord-301362-f3lp10lm	161	30	luminal	luminal	JJ
cord-301362-f3lp10lm	161	31	leaflet	leaflet	NN
cord-301362-f3lp10lm	161	32	of	of	IN
cord-301362-f3lp10lm	161	33	the	the	DT
cord-301362-f3lp10lm	161	34	ER	ER	NNP
cord-301362-f3lp10lm	161	35	membrane	membrane	NN
cord-301362-f3lp10lm	161	36	.	.	.
cord-301362-f3lp10lm	162	1	Regarding	regard	VBG
cord-301362-f3lp10lm	162	2	plant	plant	NN
cord-301362-f3lp10lm	162	3	viruses	virus	NNS
cord-301362-f3lp10lm	162	4	,	,	,
cord-301362-f3lp10lm	162	5	even	even	RB
cord-301362-f3lp10lm	162	6	though	though	IN
cord-301362-f3lp10lm	162	7	3-D	3-d	JJ
cord-301362-f3lp10lm	162	8	structural	structural	JJ
cord-301362-f3lp10lm	162	9	information	information	NN
cord-301362-f3lp10lm	162	10	on	on	IN
cord-301362-f3lp10lm	162	11	plant	plant	NN
cord-301362-f3lp10lm	162	12	+	+	SYM
cord-301362-f3lp10lm	162	13	sRNA	srna	NN
cord-301362-f3lp10lm	162	14	virus	virus	NN
cord-301362-f3lp10lm	162	15	-	-	HYPH
cord-301362-f3lp10lm	162	16	infected	infect	VBN
cord-301362-f3lp10lm	162	17	cells	cell	NNS
cord-301362-f3lp10lm	162	18	is	be	VBZ
cord-301362-f3lp10lm	162	19	limited	limit	VBN
cord-301362-f3lp10lm	162	20	,	,	,
cord-301362-f3lp10lm	162	21	virus	virus	NN
cord-301362-f3lp10lm	162	22	-	-	HYPH
cord-301362-f3lp10lm	162	23	host	host	NN
cord-301362-f3lp10lm	162	24	interactions	interaction	NNS
cord-301362-f3lp10lm	162	25	have	have	VBP
cord-301362-f3lp10lm	162	26	been	be	VBN
cord-301362-f3lp10lm	162	27	extensively	extensively	RB
cord-301362-f3lp10lm	162	28	studied	study	VBN
cord-301362-f3lp10lm	162	29	for	for	IN
cord-301362-f3lp10lm	162	30	Brome	Brome	NNP
cord-301362-f3lp10lm	162	31	Mosaic	Mosaic	NNP
cord-301362-f3lp10lm	162	32	Virus	Virus	NNP
cord-301362-f3lp10lm	162	33	(	(	-LRB-
cord-301362-f3lp10lm	162	34	BMV	BMV	NNP
cord-301362-f3lp10lm	162	35	)	)	-RRB-
cord-301362-f3lp10lm	162	36	,	,	,
cord-301362-f3lp10lm	162	37	a	a	DT
cord-301362-f3lp10lm	162	38	member	member	NN
cord-301362-f3lp10lm	162	39	of	of	IN
cord-301362-f3lp10lm	162	40	the	the	DT
cord-301362-f3lp10lm	162	41	Bromoviridae	Bromoviridae	NNP
cord-301362-f3lp10lm	162	42	family	family	NN
cord-301362-f3lp10lm	162	43	,	,	,
cord-301362-f3lp10lm	162	44	or	or	CC
cord-301362-f3lp10lm	162	45	the	the	DT
cord-301362-f3lp10lm	162	46	Beet	Beet	NNP
cord-301362-f3lp10lm	162	47	Black	Black	NNP
cord-301362-f3lp10lm	162	48	Scorch	Scorch	NNP
cord-301362-f3lp10lm	162	49	Virus	virus	NN
cord-301362-f3lp10lm	162	50	(	(	-LRB-
cord-301362-f3lp10lm	162	51	BBSV	BBSV	NNP
cord-301362-f3lp10lm	162	52	)	)	-RRB-
cord-301362-f3lp10lm	162	53	,	,	,
cord-301362-f3lp10lm	162	54	a	a	DT
cord-301362-f3lp10lm	162	55	member	member	NN
cord-301362-f3lp10lm	162	56	of	of	IN
cord-301362-f3lp10lm	162	57	the	the	DT
cord-301362-f3lp10lm	162	58	Tombusviridae	Tombusviridae	NNP
cord-301362-f3lp10lm	162	59	family	family	NN
cord-301362-f3lp10lm	162	60	,	,	,
cord-301362-f3lp10lm	162	61	both	both	DT
cord-301362-f3lp10lm	162	62	generating	generate	VBG
cord-301362-f3lp10lm	162	63	convolution	convolution	NN
cord-301362-f3lp10lm	162	64	and	and	CC
cord-301362-f3lp10lm	162	65	invagination	invagination	NN
cord-301362-f3lp10lm	162	66	of	of	IN
cord-301362-f3lp10lm	162	67	the	the	DT
cord-301362-f3lp10lm	162	68	ER	ER	NNP
cord-301362-f3lp10lm	162	69	membrane	membrane	NN
cord-301362-f3lp10lm	162	70	and	and	CC
cord-301362-f3lp10lm	162	71	neck	neck	NN
cord-301362-f3lp10lm	162	72	-	-	HYPH
cord-301362-f3lp10lm	162	73	like	like	JJ
cord-301362-f3lp10lm	162	74	channels	channel	NNS
cord-301362-f3lp10lm	162	75	connecting	connect	VBG
cord-301362-f3lp10lm	162	76	the	the	DT
cord-301362-f3lp10lm	162	77	interiors	interior	NNS
cord-301362-f3lp10lm	162	78	of	of	IN
cord-301362-f3lp10lm	162	79	spherules	spherule	NNS
cord-301362-f3lp10lm	162	80	to	to	IN
cord-301362-f3lp10lm	162	81	the	the	DT
cord-301362-f3lp10lm	162	82	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	162	83	to	to	TO
cord-301362-f3lp10lm	162	84	replicate	replicate	VB
cord-301362-f3lp10lm	162	85	inside	inside	RB
cord-301362-f3lp10lm	162	86	(	(	-LRB-
cord-301362-f3lp10lm	162	87	Bamunusinghe	Bamunusinghe	NNP
cord-301362-f3lp10lm	162	88	et	et	NNP
cord-301362-f3lp10lm	162	89	al	al	NNP
cord-301362-f3lp10lm	162	90	.	.	NNP
cord-301362-f3lp10lm	162	91	,	,	,
cord-301362-f3lp10lm	162	92	2011	2011	CD
cord-301362-f3lp10lm	162	93	;	;	:
cord-301362-f3lp10lm	162	94	Cao	Cao	NNP
cord-301362-f3lp10lm	162	95	et	et	NNP
cord-301362-f3lp10lm	162	96	al	al	NNP
cord-301362-f3lp10lm	162	97	.	.	NNP
cord-301362-f3lp10lm	162	98	,	,	,
cord-301362-f3lp10lm	162	99	2015	2015	CD
cord-301362-f3lp10lm	162	100	)	)	-RRB-
cord-301362-f3lp10lm	162	101	.	.	.
cord-301362-f3lp10lm	163	1	Polioviruses	poliovirus	NNS
cord-301362-f3lp10lm	163	2	belong	belong	VBP
cord-301362-f3lp10lm	163	3	to	to	IN
cord-301362-f3lp10lm	163	4	the	the	DT
cord-301362-f3lp10lm	163	5	genus	genus	NN
cord-301362-f3lp10lm	163	6	Enterovirus	Enterovirus	NNP
cord-301362-f3lp10lm	163	7	of	of	IN
cord-301362-f3lp10lm	163	8	Picornaviridae	Picornaviridae	NNP
cord-301362-f3lp10lm	163	9	family	family	NN
cord-301362-f3lp10lm	163	10	.	.	.
cord-301362-f3lp10lm	164	1	Viruses	virus	NNS
cord-301362-f3lp10lm	164	2	in	in	IN
cord-301362-f3lp10lm	164	3	this	this	DT
cord-301362-f3lp10lm	164	4	family	family	NN
cord-301362-f3lp10lm	164	5	have	have	VBP
cord-301362-f3lp10lm	164	6	nonenveloped	nonenvelope	VBN
cord-301362-f3lp10lm	164	7	particles	particle	NNS
cord-301362-f3lp10lm	164	8	with	with	IN
cord-301362-f3lp10lm	164	9	a	a	DT
cord-301362-f3lp10lm	164	10	tightly	tightly	RB
cord-301362-f3lp10lm	164	11	packaged	package	VBN
cord-301362-f3lp10lm	164	12	,	,	,
cord-301362-f3lp10lm	164	13	non	non	JJ
cord-301362-f3lp10lm	164	14	-	-	JJ
cord-301362-f3lp10lm	164	15	segmented	segmented	JJ
cord-301362-f3lp10lm	164	16	,	,	,
cord-301362-f3lp10lm	164	17	single	single	RB
cord-301362-f3lp10lm	164	18	-	-	HYPH
cord-301362-f3lp10lm	164	19	stranded	stranded	JJ
cord-301362-f3lp10lm	164	20	,	,	,
cord-301362-f3lp10lm	164	21	ssRNA	ssRNA	''
cord-301362-f3lp10lm	164	22	.	.	.
cord-301362-f3lp10lm	165	1	Among	among	IN
cord-301362-f3lp10lm	165	2	its	-PRON-	PRP$
cord-301362-f3lp10lm	165	3	many	many	JJ
cord-301362-f3lp10lm	165	4	members	member	NNS
cord-301362-f3lp10lm	165	5	are	be	VBP
cord-301362-f3lp10lm	165	6	numerous	numerous	JJ
cord-301362-f3lp10lm	165	7	important	important	JJ
cord-301362-f3lp10lm	165	8	human	human	NN
cord-301362-f3lp10lm	165	9	and	and	CC
cord-301362-f3lp10lm	165	10	animal	animal	NN
cord-301362-f3lp10lm	165	11	pathogens	pathogen	NNS
cord-301362-f3lp10lm	165	12	,	,	,
cord-301362-f3lp10lm	165	13	such	such	JJ
cord-301362-f3lp10lm	165	14	as	as	IN
cord-301362-f3lp10lm	165	15	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	165	16	,	,	,
cord-301362-f3lp10lm	165	17	hepatitis	hepatitis	NNP
cord-301362-f3lp10lm	165	18	A	a	DT
cord-301362-f3lp10lm	165	19	virus	virus	NN
cord-301362-f3lp10lm	165	20	,	,	,
cord-301362-f3lp10lm	165	21	foot	foot	NN
cord-301362-f3lp10lm	165	22	and	and	CC
cord-301362-f3lp10lm	165	23	mouth	mouth	NN
cord-301362-f3lp10lm	165	24	disease	disease	NN
cord-301362-f3lp10lm	165	25	virus	virus	NN
cord-301362-f3lp10lm	165	26	(	(	-LRB-
cord-301362-f3lp10lm	165	27	FMDV	FMDV	NNP
cord-301362-f3lp10lm	165	28	)	)	-RRB-
cord-301362-f3lp10lm	165	29	,	,	,
cord-301362-f3lp10lm	165	30	enterovirus	enterovirus	NN
cord-301362-f3lp10lm	165	31	71	71	CD
cord-301362-f3lp10lm	165	32	,	,	,
cord-301362-f3lp10lm	165	33	and	and	CC
cord-301362-f3lp10lm	165	34	rhinovirus	rhinovirus	NN
cord-301362-f3lp10lm	165	35	(	(	-LRB-
cord-301362-f3lp10lm	165	36	Racaniello	Racaniello	NNP
cord-301362-f3lp10lm	165	37	,	,	,
cord-301362-f3lp10lm	165	38	2013	2013	CD
cord-301362-f3lp10lm	165	39	)	)	-RRB-
cord-301362-f3lp10lm	165	40	.	.	.
cord-301362-f3lp10lm	166	1	Poliovirus	Poliovirus	NNP
cord-301362-f3lp10lm	166	2	particles	particle	NNS
cord-301362-f3lp10lm	166	3	,	,	,
cord-301362-f3lp10lm	166	4	as	as	IN
cord-301362-f3lp10lm	166	5	other	other	JJ
cord-301362-f3lp10lm	166	6	members	member	NNS
cord-301362-f3lp10lm	166	7	of	of	IN
cord-301362-f3lp10lm	166	8	the	the	DT
cord-301362-f3lp10lm	166	9	family	family	NN
cord-301362-f3lp10lm	166	10	,	,	,
cord-301362-f3lp10lm	166	11	consist	consist	VBP
cord-301362-f3lp10lm	166	12	of	of	IN
cord-301362-f3lp10lm	166	13	an	an	DT
cord-301362-f3lp10lm	166	14	icosahedral	icosahedral	JJ
cord-301362-f3lp10lm	166	15	protein	protein	NN
cord-301362-f3lp10lm	166	16	shell	shell	NN
cord-301362-f3lp10lm	166	17	surrounding	surround	VBG
cord-301362-f3lp10lm	166	18	the	the	DT
cord-301362-f3lp10lm	166	19	naked	naked	JJ
cord-301362-f3lp10lm	166	20	RNA	RNA	NNP
cord-301362-f3lp10lm	166	21	genome	genome	NN
cord-301362-f3lp10lm	166	22	of	of	IN
cord-301362-f3lp10lm	166	23	around	around	RB
cord-301362-f3lp10lm	166	24	7500	7500	CD
cord-301362-f3lp10lm	166	25	nucleotides	nucleotide	NNS
cord-301362-f3lp10lm	166	26	.	.	.
cord-301362-f3lp10lm	167	1	The	the	DT
cord-301362-f3lp10lm	167	2	basic	basic	JJ
cord-301362-f3lp10lm	167	3	building	building	NN
cord-301362-f3lp10lm	167	4	block	block	NN
cord-301362-f3lp10lm	167	5	of	of	IN
cord-301362-f3lp10lm	167	6	the	the	DT
cord-301362-f3lp10lm	167	7	picornavirus	picornavirus	NNP
cord-301362-f3lp10lm	167	8	capsid	capsid	NN
cord-301362-f3lp10lm	167	9	is	be	VBZ
cord-301362-f3lp10lm	167	10	a	a	DT
cord-301362-f3lp10lm	167	11	protomer	protomer	NN
cord-301362-f3lp10lm	167	12	,	,	,
cord-301362-f3lp10lm	167	13	which	which	WDT
cord-301362-f3lp10lm	167	14	contains	contain	VBZ
cord-301362-f3lp10lm	167	15	one	one	CD
cord-301362-f3lp10lm	167	16	copy	copy	NN
cord-301362-f3lp10lm	167	17	each	each	DT
cord-301362-f3lp10lm	167	18	of	of	IN
cord-301362-f3lp10lm	167	19	four	four	CD
cord-301362-f3lp10lm	167	20	structural	structural	JJ
cord-301362-f3lp10lm	167	21	proteins	protein	NNS
cord-301362-f3lp10lm	167	22	:	:	:
cord-301362-f3lp10lm	167	23	VP1	VP1	NNP
cord-301362-f3lp10lm	167	24	,	,	,
cord-301362-f3lp10lm	167	25	VP2	vp2	NN
cord-301362-f3lp10lm	167	26	,	,	,
cord-301362-f3lp10lm	167	27	VP3	VP3	NNP
cord-301362-f3lp10lm	167	28	,	,	,
cord-301362-f3lp10lm	167	29	and	and	CC
cord-301362-f3lp10lm	167	30	VP4	VP4	NNP
cord-301362-f3lp10lm	167	31	.	.	.
cord-301362-f3lp10lm	168	1	The	the	DT
cord-301362-f3lp10lm	168	2	shell	shell	NN
cord-301362-f3lp10lm	168	3	is	be	VBZ
cord-301362-f3lp10lm	168	4	formed	form	VBN
cord-301362-f3lp10lm	168	5	by	by	IN
cord-301362-f3lp10lm	168	6	VP1-VP3	VP1-VP3	NNP
cord-301362-f3lp10lm	168	7	,	,	,
cord-301362-f3lp10lm	168	8	and	and	CC
cord-301362-f3lp10lm	168	9	VP4	VP4	NNP
cord-301362-f3lp10lm	168	10	lies	lie	VBZ
cord-301362-f3lp10lm	168	11	on	on	IN
cord-301362-f3lp10lm	168	12	its	-PRON-	PRP$
cord-301362-f3lp10lm	168	13	inner	inner	JJ
cord-301362-f3lp10lm	168	14	surface	surface	NN
cord-301362-f3lp10lm	168	15	(	(	-LRB-
cord-301362-f3lp10lm	168	16	Fry	Fry	NNP
cord-301362-f3lp10lm	168	17	and	and	CC
cord-301362-f3lp10lm	168	18	Stuart	Stuart	NNP
cord-301362-f3lp10lm	168	19	,	,	,
cord-301362-f3lp10lm	168	20	2010	2010	CD
cord-301362-f3lp10lm	168	21	)	)	-RRB-
cord-301362-f3lp10lm	168	22	.	.	.
cord-301362-f3lp10lm	169	1	The	the	DT
cord-301362-f3lp10lm	169	2	viral	viral	JJ
cord-301362-f3lp10lm	169	3	ARN	arn	NN
cord-301362-f3lp10lm	169	4	encodes	encode	VBZ
cord-301362-f3lp10lm	169	5	a	a	DT
cord-301362-f3lp10lm	169	6	single	single	JJ
cord-301362-f3lp10lm	169	7	poliprotein	poliprotein	NN
cord-301362-f3lp10lm	169	8	,	,	,
cord-301362-f3lp10lm	169	9	which	which	WDT
cord-301362-f3lp10lm	169	10	is	be	VBZ
cord-301362-f3lp10lm	169	11	cleaved	cleave	VBN
cord-301362-f3lp10lm	169	12	by	by	IN
cord-301362-f3lp10lm	169	13	virus	virus	NN
cord-301362-f3lp10lm	169	14	-	-	HYPH
cord-301362-f3lp10lm	169	15	encoded	encode	VBN
cord-301362-f3lp10lm	169	16	proteinases	proteinase	NNS
cord-301362-f3lp10lm	169	17	to	to	TO
cord-301362-f3lp10lm	169	18	yield	yield	VB
cord-301362-f3lp10lm	169	19	11	11	CD
cord-301362-f3lp10lm	169	20	-	-	SYM
cord-301362-f3lp10lm	169	21	15	15	CD
cord-301362-f3lp10lm	169	22	final	final	JJ
cord-301362-f3lp10lm	169	23	polypeptides	polypeptide	NNS
cord-301362-f3lp10lm	169	24	.	.	.
cord-301362-f3lp10lm	170	1	The	the	DT
cord-301362-f3lp10lm	170	2	polyprotein	polyprotein	NN
cord-301362-f3lp10lm	170	3	contains	contain	VBZ
cord-301362-f3lp10lm	170	4	three	three	CD
cord-301362-f3lp10lm	170	5	regions	region	NNS
cord-301362-f3lp10lm	170	6	:	:	:
cord-301362-f3lp10lm	170	7	P1	P1	NNP
cord-301362-f3lp10lm	170	8	,	,	,
cord-301362-f3lp10lm	170	9	P2	P2	NNP
cord-301362-f3lp10lm	170	10	,	,	,
cord-301362-f3lp10lm	170	11	and	and	CC
cord-301362-f3lp10lm	170	12	P3	P3	NNP
cord-301362-f3lp10lm	170	13	.	.	.
cord-301362-f3lp10lm	171	1	The	the	DT
cord-301362-f3lp10lm	171	2	P1	P1	NNP
cord-301362-f3lp10lm	171	3	region	region	NN
cord-301362-f3lp10lm	171	4	encodes	encode	VBZ
cord-301362-f3lp10lm	171	5	the	the	DT
cord-301362-f3lp10lm	171	6	viral	viral	JJ
cord-301362-f3lp10lm	171	7	capsid	capsid	NN
cord-301362-f3lp10lm	171	8	proteins	protein	NNS
cord-301362-f3lp10lm	171	9	,	,	,
cord-301362-f3lp10lm	171	10	whereas	whereas	IN
cord-301362-f3lp10lm	171	11	the	the	DT
cord-301362-f3lp10lm	171	12	P2	P2	NNP
cord-301362-f3lp10lm	171	13	and	and	CC
cord-301362-f3lp10lm	171	14	P3	P3	NNP
cord-301362-f3lp10lm	171	15	regions	region	NNS
cord-301362-f3lp10lm	171	16	encode	encode	VBP
cord-301362-f3lp10lm	171	17	proteins	protein	NNS
cord-301362-f3lp10lm	171	18	involved	involve	VBN
cord-301362-f3lp10lm	171	19	in	in	IN
cord-301362-f3lp10lm	171	20	protein	protein	NN
cord-301362-f3lp10lm	171	21	processing	processing	NN
cord-301362-f3lp10lm	171	22	and	and	CC
cord-301362-f3lp10lm	171	23	genome	genome	NN
cord-301362-f3lp10lm	171	24	replication	replication	NN
cord-301362-f3lp10lm	171	25	(	(	-LRB-
cord-301362-f3lp10lm	171	26	Stanway	Stanway	NNP
cord-301362-f3lp10lm	171	27	,	,	,
cord-301362-f3lp10lm	171	28	1990	1990	CD
cord-301362-f3lp10lm	171	29	)	)	-RRB-
cord-301362-f3lp10lm	171	30	.	.	.
cord-301362-f3lp10lm	172	1	The	the	DT
cord-301362-f3lp10lm	172	2	initial	initial	JJ
cord-301362-f3lp10lm	172	3	attachment	attachment	NN
cord-301362-f3lp10lm	172	4	of	of	IN
cord-301362-f3lp10lm	172	5	the	the	DT
cord-301362-f3lp10lm	172	6	virion	virion	NN
cord-301362-f3lp10lm	172	7	to	to	IN
cord-301362-f3lp10lm	172	8	the	the	DT
cord-301362-f3lp10lm	172	9	host	host	NN
cord-301362-f3lp10lm	172	10	cell	cell	NN
cord-301362-f3lp10lm	172	11	plasma	plasma	NN
cord-301362-f3lp10lm	172	12	membrane	membrane	NN
cord-301362-f3lp10lm	172	13	involves	involve	VBZ
cord-301362-f3lp10lm	172	14	the	the	DT
cord-301362-f3lp10lm	172	15	receptor	receptor	NN
cord-301362-f3lp10lm	172	16	CD155	cd155	NN
cord-301362-f3lp10lm	172	17	,	,	,
cord-301362-f3lp10lm	172	18	a	a	DT
cord-301362-f3lp10lm	172	19	type	type	NN
cord-301362-f3lp10lm	172	20	I	-PRON-	PRP
cord-301362-f3lp10lm	172	21	transmembrane	transmembrane	NN
cord-301362-f3lp10lm	172	22	protein	protein	NN
cord-301362-f3lp10lm	172	23	member	member	NN
cord-301362-f3lp10lm	172	24	of	of	IN
cord-301362-f3lp10lm	172	25	the	the	DT
cord-301362-f3lp10lm	172	26	immunoglobulin	immunoglobulin	NN
cord-301362-f3lp10lm	172	27	superfamily	superfamily	NN
cord-301362-f3lp10lm	172	28	of	of	IN
cord-301362-f3lp10lm	172	29	proteins	protein	NNS
cord-301362-f3lp10lm	173	1	(	(	-LRB-
cord-301362-f3lp10lm	173	2	Mendelsohn	Mendelsohn	NNP
cord-301362-f3lp10lm	173	3	et	et	NNP
cord-301362-f3lp10lm	173	4	al	al	NNP
cord-301362-f3lp10lm	173	5	.	.	NNP
cord-301362-f3lp10lm	173	6	,	,	,
cord-301362-f3lp10lm	173	7	1989	1989	CD
cord-301362-f3lp10lm	173	8	)	)	-RRB-
cord-301362-f3lp10lm	173	9	,	,	,
cord-301362-f3lp10lm	173	10	causing	cause	VBG
cord-301362-f3lp10lm	173	11	a	a	DT
cord-301362-f3lp10lm	173	12	conformational	conformational	JJ
cord-301362-f3lp10lm	173	13	change	change	NN
cord-301362-f3lp10lm	173	14	in	in	IN
cord-301362-f3lp10lm	173	15	the	the	DT
cord-301362-f3lp10lm	173	16	capsid	capsid	NN
cord-301362-f3lp10lm	173	17	which	which	WDT
cord-301362-f3lp10lm	173	18	leads	lead	VBZ
cord-301362-f3lp10lm	173	19	to	to	IN
cord-301362-f3lp10lm	173	20	viral	viral	JJ
cord-301362-f3lp10lm	173	21	internalization	internalization	NN
cord-301362-f3lp10lm	173	22	via	via	IN
cord-301362-f3lp10lm	173	23	a	a	DT
cord-301362-f3lp10lm	173	24	clathrinindependent	clathrinindependent	NN
cord-301362-f3lp10lm	173	25	endocytic	endocytic	NN
cord-301362-f3lp10lm	173	26	process	process	NN
cord-301362-f3lp10lm	173	27	(	(	-LRB-
cord-301362-f3lp10lm	173	28	Fricks	Fricks	NNP
cord-301362-f3lp10lm	173	29	and	and	CC
cord-301362-f3lp10lm	173	30	Hogle	Hogle	NNP
cord-301362-f3lp10lm	173	31	,	,	,
cord-301362-f3lp10lm	173	32	1990	1990	CD
cord-301362-f3lp10lm	174	1	;	;	:
cord-301362-f3lp10lm	174	2	Tuthill	Tuthill	NNP
cord-301362-f3lp10lm	174	3	et	et	NNP
cord-301362-f3lp10lm	174	4	al	al	NNP
cord-301362-f3lp10lm	174	5	.	.	NNP
cord-301362-f3lp10lm	174	6	,	,	,
cord-301362-f3lp10lm	174	7	2006	2006	CD
cord-301362-f3lp10lm	174	8	)	)	-RRB-
cord-301362-f3lp10lm	174	9	.	.	.
cord-301362-f3lp10lm	175	1	Upon	upon	IN
cord-301362-f3lp10lm	175	2	infection	infection	NN
cord-301362-f3lp10lm	175	3	,	,	,
cord-301362-f3lp10lm	175	4	the	the	DT
cord-301362-f3lp10lm	175	5	virus	virus	NN
cord-301362-f3lp10lm	175	6	genome	genome	NN
cord-301362-f3lp10lm	175	7	replication	replication	NN
cord-301362-f3lp10lm	175	8	occurs	occur	VBZ
cord-301362-f3lp10lm	175	9	in	in	IN
cord-301362-f3lp10lm	175	10	the	the	DT
cord-301362-f3lp10lm	175	11	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	175	12	associated	associate	VBN
cord-301362-f3lp10lm	175	13	to	to	IN
cord-301362-f3lp10lm	175	14	complex	complex	JJ
cord-301362-f3lp10lm	175	15	membranous	membranous	JJ
cord-301362-f3lp10lm	175	16	replication	replication	NN
cord-301362-f3lp10lm	175	17	factories	factory	NNS
cord-301362-f3lp10lm	175	18	.	.	.
cord-301362-f3lp10lm	176	1	The	the	DT
cord-301362-f3lp10lm	176	2	first	first	JJ
cord-301362-f3lp10lm	176	3	step	step	NN
cord-301362-f3lp10lm	176	4	in	in	IN
cord-301362-f3lp10lm	176	5	genome	genome	NN
cord-301362-f3lp10lm	176	6	replication	replication	NN
cord-301362-f3lp10lm	176	7	is	be	VBZ
cord-301362-f3lp10lm	176	8	copying	copy	VBG
cord-301362-f3lp10lm	176	9	of	of	IN
cord-301362-f3lp10lm	176	10	the	the	DT
cord-301362-f3lp10lm	176	11	positive	positive	JJ
cord-301362-f3lp10lm	176	12	stranded	strand	VBN
cord-301362-f3lp10lm	176	13	RNA	RNA	NNP
cord-301362-f3lp10lm	176	14	to	to	TO
cord-301362-f3lp10lm	176	15	form	form	VB
cord-301362-f3lp10lm	176	16	a	a	DT
cord-301362-f3lp10lm	176	17	negative	negative	JJ
cord-301362-f3lp10lm	176	18	stranded	strand	VBN
cord-301362-f3lp10lm	176	19	intermediate	intermediate	JJ
cord-301362-f3lp10lm	176	20	;	;	:
cord-301362-f3lp10lm	176	21	this	this	DT
cord-301362-f3lp10lm	176	22	step	step	NN
cord-301362-f3lp10lm	176	23	is	be	VBZ
cord-301362-f3lp10lm	176	24	followed	follow	VBN
cord-301362-f3lp10lm	176	25	by	by	IN
cord-301362-f3lp10lm	176	26	the	the	DT
cord-301362-f3lp10lm	176	27	production	production	NN
cord-301362-f3lp10lm	176	28	of	of	IN
cord-301362-f3lp10lm	176	29	additional	additional	JJ
cord-301362-f3lp10lm	176	30	positive	positive	JJ
cord-301362-f3lp10lm	176	31	strands	strand	NNS
cord-301362-f3lp10lm	176	32	(	(	-LRB-
cord-301362-f3lp10lm	176	33	for	for	IN
cord-301362-f3lp10lm	176	34	a	a	DT
cord-301362-f3lp10lm	176	35	revision	revision	NN
cord-301362-f3lp10lm	176	36	see	see	VB
cord-301362-f3lp10lm	176	37	Paul	Paul	NNP
cord-301362-f3lp10lm	176	38	and	and	CC
cord-301362-f3lp10lm	176	39	Wimmer	Wimmer	NNP
cord-301362-f3lp10lm	176	40	,	,	,
cord-301362-f3lp10lm	176	41	2015	2015	CD
cord-301362-f3lp10lm	176	42	)	)	-RRB-
cord-301362-f3lp10lm	176	43	.	.	.
cord-301362-f3lp10lm	177	1	It	-PRON-	PRP
cord-301362-f3lp10lm	177	2	is	be	VBZ
cord-301362-f3lp10lm	177	3	believed	believe	VBN
cord-301362-f3lp10lm	177	4	that	that	IN
cord-301362-f3lp10lm	177	5	the	the	DT
cord-301362-f3lp10lm	177	6	dsRNA	dsrna	NN
cord-301362-f3lp10lm	177	7	functions	function	NNS
cord-301362-f3lp10lm	177	8	as	as	IN
cord-301362-f3lp10lm	177	9	replicative	replicative	JJ
cord-301362-f3lp10lm	177	10	intermediate	intermediate	JJ
cord-301362-f3lp10lm	177	11	during	during	IN
cord-301362-f3lp10lm	177	12	the	the	DT
cord-301362-f3lp10lm	177	13	synthesis	synthesis	NN
cord-301362-f3lp10lm	177	14	of	of	IN
cord-301362-f3lp10lm	177	15	viral	viral	JJ
cord-301362-f3lp10lm	177	16	RNA	RNA	NNP
cord-301362-f3lp10lm	177	17	.	.	.
cord-301362-f3lp10lm	178	1	A	a	DT
cord-301362-f3lp10lm	178	2	hallmark	hallmark	NN
cord-301362-f3lp10lm	178	3	of	of	IN
cord-301362-f3lp10lm	178	4	this	this	DT
cord-301362-f3lp10lm	178	5	type	type	NN
cord-301362-f3lp10lm	178	6	of	of	IN
cord-301362-f3lp10lm	178	7	virus	virus	NN
cord-301362-f3lp10lm	178	8	is	be	VBZ
cord-301362-f3lp10lm	178	9	the	the	DT
cord-301362-f3lp10lm	178	10	remarkably	remarkably	RB
cord-301362-f3lp10lm	178	11	rearrangement	rearrangement	NN
cord-301362-f3lp10lm	178	12	of	of	IN
cord-301362-f3lp10lm	178	13	cellular	cellular	JJ
cord-301362-f3lp10lm	178	14	membranes	membrane	NNS
cord-301362-f3lp10lm	178	15	into	into	IN
cord-301362-f3lp10lm	178	16	organellelike	organellelike	JJ
cord-301362-f3lp10lm	178	17	replicative	replicative	JJ
cord-301362-f3lp10lm	178	18	factories	factory	NNS
cord-301362-f3lp10lm	178	19	.	.	.
cord-301362-f3lp10lm	179	1	Interestingly	interestingly	RB
cord-301362-f3lp10lm	179	2	,	,	,
cord-301362-f3lp10lm	179	3	it	-PRON-	PRP
cord-301362-f3lp10lm	179	4	has	have	VBZ
cord-301362-f3lp10lm	179	5	been	be	VBN
cord-301362-f3lp10lm	179	6	determined	determine	VBN
cord-301362-f3lp10lm	179	7	that	that	IN
cord-301362-f3lp10lm	179	8	newly	newly	RB
cord-301362-f3lp10lm	179	9	synthetized	synthetize	VBN
cord-301362-f3lp10lm	179	10	membranous	membranous	JJ
cord-301362-f3lp10lm	179	11	structures	structure	NNS
cord-301362-f3lp10lm	179	12	,	,	,
cord-301362-f3lp10lm	179	13	but	but	CC
cord-301362-f3lp10lm	179	14	not	not	RB
cord-301362-f3lp10lm	179	15	preexisting	preexist	VBG
cord-301362-f3lp10lm	179	16	cell	cell	NN
cord-301362-f3lp10lm	179	17	membranes	membrane	NNS
cord-301362-f3lp10lm	179	18	,	,	,
cord-301362-f3lp10lm	179	19	are	be	VBP
cord-301362-f3lp10lm	179	20	required	require	VBN
cord-301362-f3lp10lm	179	21	for	for	IN
cord-301362-f3lp10lm	179	22	viral	viral	JJ
cord-301362-f3lp10lm	179	23	replication	replication	NN
cord-301362-f3lp10lm	179	24	.	.	.
cord-301362-f3lp10lm	180	1	Thus	thus	RB
cord-301362-f3lp10lm	180	2	,	,	,
cord-301362-f3lp10lm	180	3	the	the	DT
cord-301362-f3lp10lm	180	4	formation	formation	NN
cord-301362-f3lp10lm	180	5	of	of	IN
cord-301362-f3lp10lm	180	6	the	the	DT
cord-301362-f3lp10lm	180	7	complex	complex	JJ
cord-301362-f3lp10lm	180	8	replication	replication	NN
cord-301362-f3lp10lm	180	9	factories	factory	NNS
cord-301362-f3lp10lm	180	10	requires	require	VBZ
cord-301362-f3lp10lm	180	11	coupled	couple	VBN
cord-301362-f3lp10lm	180	12	viral	viral	JJ
cord-301362-f3lp10lm	180	13	translation	translation	NN
cord-301362-f3lp10lm	180	14	,	,	,
cord-301362-f3lp10lm	180	15	lipid	lipid	NN
cord-301362-f3lp10lm	180	16	synthesis	synthesis	NN
cord-301362-f3lp10lm	180	17	,	,	,
cord-301362-f3lp10lm	180	18	new	new	JJ
cord-301362-f3lp10lm	180	19	membranes	membrane	NNS
cord-301362-f3lp10lm	180	20	generation	generation	NN
cord-301362-f3lp10lm	180	21	and	and	CC
cord-301362-f3lp10lm	180	22	viral	viral	JJ
cord-301362-f3lp10lm	180	23	RNA	RNA	NNP
cord-301362-f3lp10lm	180	24	synthesis	synthesis	NN
cord-301362-f3lp10lm	180	25	(	(	-LRB-
cord-301362-f3lp10lm	180	26	reviewed	review	VBN
cord-301362-f3lp10lm	180	27	by	by	IN
cord-301362-f3lp10lm	180	28	Rossignol	Rossignol	NNP
cord-301362-f3lp10lm	180	29	et	et	NNP
cord-301362-f3lp10lm	180	30	al	al	NNP
cord-301362-f3lp10lm	180	31	.	.	NNP
cord-301362-f3lp10lm	180	32	,	,	,
cord-301362-f3lp10lm	180	33	2015	2015	CD
cord-301362-f3lp10lm	180	34	)	)	-RRB-
cord-301362-f3lp10lm	180	35	.	.	.
cord-301362-f3lp10lm	181	1	Early	early	RB
cord-301362-f3lp10lm	181	2	in	in	IN
cord-301362-f3lp10lm	181	3	the	the	DT
cord-301362-f3lp10lm	181	4	70	70	CD
cord-301362-f3lp10lm	181	5	's	's	POS
cord-301362-f3lp10lm	181	6	,	,	,
cord-301362-f3lp10lm	181	7	based	base	VBN
cord-301362-f3lp10lm	181	8	on	on	IN
cord-301362-f3lp10lm	181	9	the	the	DT
cord-301362-f3lp10lm	181	10	incorporation	incorporation	NN
cord-301362-f3lp10lm	181	11	of	of	IN
cord-301362-f3lp10lm	181	12	modified	modified	JJ
cord-301362-f3lp10lm	181	13	lipids	lipid	NNS
cord-301362-f3lp10lm	181	14	into	into	IN
cord-301362-f3lp10lm	181	15	the	the	DT
cord-301362-f3lp10lm	181	16	membranes	membrane	NNS
cord-301362-f3lp10lm	181	17	of	of	IN
cord-301362-f3lp10lm	181	18	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	181	19	replication	replication	NN
cord-301362-f3lp10lm	181	20	sites	site	NNS
cord-301362-f3lp10lm	181	21	(	(	-LRB-
cord-301362-f3lp10lm	181	22	Mosser	Mosser	NNP
cord-301362-f3lp10lm	181	23	et	et	NNP
cord-301362-f3lp10lm	181	24	al	al	NNP
cord-301362-f3lp10lm	181	25	.	.	NNP
cord-301362-f3lp10lm	181	26	,	,	,
cord-301362-f3lp10lm	181	27	1972	1972	CD
cord-301362-f3lp10lm	181	28	)	)	-RRB-
cord-301362-f3lp10lm	181	29	indicated	indicate	VBD
cord-301362-f3lp10lm	181	30	that	that	IN
cord-301362-f3lp10lm	181	31	these	these	DT
cord-301362-f3lp10lm	181	32	structures	structure	NNS
cord-301362-f3lp10lm	181	33	are	be	VBP
cord-301362-f3lp10lm	181	34	different	different	JJ
cord-301362-f3lp10lm	181	35	from	from	IN
cord-301362-f3lp10lm	181	36	pre	pre	JJ
cord-301362-f3lp10lm	181	37	-	-	JJ
cord-301362-f3lp10lm	181	38	existing	existing	JJ
cord-301362-f3lp10lm	181	39	membranous	membranous	JJ
cord-301362-f3lp10lm	181	40	compartments	compartment	NNS
cord-301362-f3lp10lm	181	41	,	,	,
cord-301362-f3lp10lm	181	42	clearly	clearly	RB
cord-301362-f3lp10lm	181	43	demonstrating	demonstrate	VBG
cord-301362-f3lp10lm	181	44	that	that	IN
cord-301362-f3lp10lm	181	45	the	the	DT
cord-301362-f3lp10lm	181	46	virus	virus	NN
cord-301362-f3lp10lm	181	47	replication	replication	NN
cord-301362-f3lp10lm	181	48	factories	factory	NNS
cord-301362-f3lp10lm	181	49	are	be	VBP
cord-301362-f3lp10lm	181	50	"	"	``
cord-301362-f3lp10lm	181	51	self	self	NN
cord-301362-f3lp10lm	181	52	-	-	HYPH
cord-301362-f3lp10lm	181	53	tailored	tailor	VBN
cord-301362-f3lp10lm	181	54	"	"	''
cord-301362-f3lp10lm	181	55	(	(	-LRB-
cord-301362-f3lp10lm	181	56	Mosser	Mosser	NNP
cord-301362-f3lp10lm	181	57	et	et	FW
cord-301362-f3lp10lm	181	58	al	al	NNP
cord-301362-f3lp10lm	181	59	.	.	NNP
cord-301362-f3lp10lm	181	60	,	,	,
cord-301362-f3lp10lm	181	61	1972	1972	CD
cord-301362-f3lp10lm	181	62	)	)	-RRB-
cord-301362-f3lp10lm	181	63	.	.	.
cord-301362-f3lp10lm	182	1	It	-PRON-	PRP
cord-301362-f3lp10lm	182	2	was	be	VBD
cord-301362-f3lp10lm	182	3	shown	show	VBN
cord-301362-f3lp10lm	182	4	that	that	IN
cord-301362-f3lp10lm	182	5	several	several	JJ
cord-301362-f3lp10lm	182	6	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	182	7	and	and	CC
cord-301362-f3lp10lm	182	8	host	host	NN
cord-301362-f3lp10lm	182	9	proteins	protein	NNS
cord-301362-f3lp10lm	182	10	are	be	VBP
cord-301362-f3lp10lm	182	11	involved	involve	VBN
cord-301362-f3lp10lm	182	12	in	in	IN
cord-301362-f3lp10lm	182	13	the	the	DT
cord-301362-f3lp10lm	182	14	membrane	membrane	NN
cord-301362-f3lp10lm	182	15	rearrangements	rearrangement	NNS
cord-301362-f3lp10lm	182	16	that	that	WDT
cord-301362-f3lp10lm	182	17	are	be	VBP
cord-301362-f3lp10lm	182	18	essential	essential	JJ
cord-301362-f3lp10lm	182	19	for	for	IN
cord-301362-f3lp10lm	182	20	virus	virus	NN
cord-301362-f3lp10lm	182	21	RNA	RNA	NNP
cord-301362-f3lp10lm	182	22	replication	replication	NN
cord-301362-f3lp10lm	182	23	(	(	-LRB-
cord-301362-f3lp10lm	182	24	reviewed	review	VBN
cord-301362-f3lp10lm	182	25	by	by	IN
cord-301362-f3lp10lm	182	26	Jackson	Jackson	NNP
cord-301362-f3lp10lm	182	27	,	,	,
cord-301362-f3lp10lm	182	28	2014	2014	CD
cord-301362-f3lp10lm	182	29	)	)	-RRB-
cord-301362-f3lp10lm	182	30	.	.	.
cord-301362-f3lp10lm	183	1	To	to	TO
cord-301362-f3lp10lm	183	2	explore	explore	VB
cord-301362-f3lp10lm	183	3	the	the	DT
cord-301362-f3lp10lm	183	4	role	role	NN
cord-301362-f3lp10lm	183	5	of	of	IN
cord-301362-f3lp10lm	183	6	individual	individual	JJ
cord-301362-f3lp10lm	183	7	viral	viral	JJ
cord-301362-f3lp10lm	183	8	proteins	protein	NNS
cord-301362-f3lp10lm	183	9	,	,	,
cord-301362-f3lp10lm	183	10	cells	cell	NNS
cord-301362-f3lp10lm	183	11	were	be	VBD
cord-301362-f3lp10lm	183	12	transfected	transfecte	VBN
cord-301362-f3lp10lm	183	13	or	or	CC
cord-301362-f3lp10lm	183	14	microinjected	microinjecte	VBN
cord-301362-f3lp10lm	183	15	and	and	CC
cord-301362-f3lp10lm	183	16	visualized	visualize	VBN
cord-301362-f3lp10lm	183	17	by	by	IN
cord-301362-f3lp10lm	183	18	electron	electron	NN
cord-301362-f3lp10lm	183	19	microscopy	microscopy	NN
cord-301362-f3lp10lm	183	20	to	to	TO
cord-301362-f3lp10lm	183	21	study	study	VB
cord-301362-f3lp10lm	183	22	the	the	DT
cord-301362-f3lp10lm	183	23	complex	complex	JJ
cord-301362-f3lp10lm	183	24	cellular	cellular	JJ
cord-301362-f3lp10lm	183	25	changes	change	NNS
cord-301362-f3lp10lm	183	26	that	that	WDT
cord-301362-f3lp10lm	183	27	take	take	VBP
cord-301362-f3lp10lm	183	28	place	place	NN
cord-301362-f3lp10lm	183	29	during	during	IN
cord-301362-f3lp10lm	183	30	viral	viral	JJ
cord-301362-f3lp10lm	183	31	infection	infection	NN
cord-301362-f3lp10lm	183	32	.	.	.
cord-301362-f3lp10lm	184	1	The	the	DT
cord-301362-f3lp10lm	184	2	viral	viral	JJ
cord-301362-f3lp10lm	184	3	protein	protein	NN
cord-301362-f3lp10lm	184	4	2BC	2bc	NN
cord-301362-f3lp10lm	184	5	(	(	-LRB-
cord-301362-f3lp10lm	184	6	a	a	DT
cord-301362-f3lp10lm	184	7	P2	P2	NNP
cord-301362-f3lp10lm	184	8	proteolytic	proteolytic	JJ
cord-301362-f3lp10lm	184	9	precursor	precursor	NN
cord-301362-f3lp10lm	184	10	of	of	IN
cord-301362-f3lp10lm	184	11	2B	2B	NNP
cord-301362-f3lp10lm	184	12	and	and	CC
cord-301362-f3lp10lm	184	13	2C	2C	NNP
cord-301362-f3lp10lm	184	14	proteins	protein	NNS
cord-301362-f3lp10lm	184	15	)	)	-RRB-
cord-301362-f3lp10lm	184	16	is	be	VBZ
cord-301362-f3lp10lm	184	17	responsible	responsible	JJ
cord-301362-f3lp10lm	184	18	for	for	IN
cord-301362-f3lp10lm	184	19	the	the	DT
cord-301362-f3lp10lm	184	20	generation	generation	NN
cord-301362-f3lp10lm	184	21	of	of	IN
cord-301362-f3lp10lm	184	22	50	50	CD
cord-301362-f3lp10lm	184	23	-	-	SYM
cord-301362-f3lp10lm	184	24	350	350	CD
cord-301362-f3lp10lm	184	25	nm	nm	NN
cord-301362-f3lp10lm	184	26	clusters	cluster	NNS
cord-301362-f3lp10lm	184	27	of	of	IN
cord-301362-f3lp10lm	184	28	empty	empty	JJ
cord-301362-f3lp10lm	184	29	vesicles	vesicle	NNS
cord-301362-f3lp10lm	184	30	limited	limit	VBN
cord-301362-f3lp10lm	184	31	by	by	IN
cord-301362-f3lp10lm	184	32	a	a	DT
cord-301362-f3lp10lm	184	33	single	single	JJ
cord-301362-f3lp10lm	184	34	membrane	membrane	NN
cord-301362-f3lp10lm	184	35	,	,	,
cord-301362-f3lp10lm	184	36	usually	usually	RB
cord-301362-f3lp10lm	184	37	in	in	IN
cord-301362-f3lp10lm	184	38	peripheral	peripheral	JJ
cord-301362-f3lp10lm	184	39	regions	region	NNS
cord-301362-f3lp10lm	184	40	of	of	IN
cord-301362-f3lp10lm	184	41	the	the	DT
cord-301362-f3lp10lm	184	42	cell	cell	NN
cord-301362-f3lp10lm	184	43	containing	contain	VBG
cord-301362-f3lp10lm	184	44	a	a	DT
cord-301362-f3lp10lm	184	45	high	high	JJ
cord-301362-f3lp10lm	184	46	concentration	concentration	NN
cord-301362-f3lp10lm	184	47	of	of	IN
cord-301362-f3lp10lm	184	48	the	the	DT
cord-301362-f3lp10lm	184	49	2C	2C	NNP
cord-301362-f3lp10lm	184	50	epitope	epitope	NNP
cord-301362-f3lp10lm	184	51	(	(	-LRB-
cord-301362-f3lp10lm	184	52	Suhy	Suhy	NNP
cord-301362-f3lp10lm	184	53	et	et	FW
cord-301362-f3lp10lm	184	54	al	al	NNP
cord-301362-f3lp10lm	184	55	.	.	NNP
cord-301362-f3lp10lm	184	56	,	,	,
cord-301362-f3lp10lm	184	57	2000	2000	CD
cord-301362-f3lp10lm	184	58	)	)	-RRB-
cord-301362-f3lp10lm	184	59	.	.	.
cord-301362-f3lp10lm	185	1	In	in	IN
cord-301362-f3lp10lm	185	2	contrast	contrast	NN
cord-301362-f3lp10lm	185	3	,	,	,
cord-301362-f3lp10lm	185	4	when	when	WRB
cord-301362-f3lp10lm	185	5	2BC	2BC	NNP
cord-301362-f3lp10lm	185	6	and	and	CC
cord-301362-f3lp10lm	185	7	3A	3a	NN
cord-301362-f3lp10lm	185	8	proteins	protein	NNS
cord-301362-f3lp10lm	185	9	are	be	VBP
cord-301362-f3lp10lm	185	10	expressed	express	VBN
cord-301362-f3lp10lm	185	11	,	,	,
cord-301362-f3lp10lm	185	12	membrane	membrane	NN
cord-301362-f3lp10lm	185	13	vesicles	vesicle	NNS
cord-301362-f3lp10lm	185	14	that	that	WDT
cord-301362-f3lp10lm	185	15	displayed	display	VBD
cord-301362-f3lp10lm	185	16	double	double	JJ
cord-301362-f3lp10lm	185	17	membranes	membrane	NNS
cord-301362-f3lp10lm	185	18	,	,	,
cord-301362-f3lp10lm	185	19	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	185	20	luminal	luminal	JJ
cord-301362-f3lp10lm	185	21	contents	content	NNS
cord-301362-f3lp10lm	185	22	,	,	,
cord-301362-f3lp10lm	185	23	and	and	CC
cord-301362-f3lp10lm	185	24	substantial	substantial	JJ
cord-301362-f3lp10lm	185	25	immunolabeling	immunolabeling	NN
cord-301362-f3lp10lm	185	26	by	by	IN
cord-301362-f3lp10lm	185	27	anti-2C	anti-2c	JJ
cord-301362-f3lp10lm	185	28	antibody	antibody	NN
cord-301362-f3lp10lm	185	29	were	be	VBD
cord-301362-f3lp10lm	185	30	observed	observe	VBN
cord-301362-f3lp10lm	185	31	resembled	resemble	VBD
cord-301362-f3lp10lm	185	32	those	those	DT
cord-301362-f3lp10lm	185	33	observed	observe	VBN
cord-301362-f3lp10lm	185	34	during	during	IN
cord-301362-f3lp10lm	185	35	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	185	36	infection	infection	NN
cord-301362-f3lp10lm	185	37	and	and	CC
cord-301362-f3lp10lm	185	38	consistent	consistent	JJ
cord-301362-f3lp10lm	185	39	with	with	IN
cord-301362-f3lp10lm	185	40	the	the	DT
cord-301362-f3lp10lm	185	41	idea	idea	NN
cord-301362-f3lp10lm	185	42	of	of	IN
cord-301362-f3lp10lm	185	43	an	an	DT
cord-301362-f3lp10lm	185	44	autophagic	autophagic	JJ
cord-301362-f3lp10lm	185	45	origin	origin	NN
cord-301362-f3lp10lm	185	46	for	for	IN
cord-301362-f3lp10lm	185	47	these	these	DT
cord-301362-f3lp10lm	185	48	membranes	membrane	NNS
cord-301362-f3lp10lm	185	49	(	(	-LRB-
cord-301362-f3lp10lm	185	50	Schlegel	Schlegel	NNP
cord-301362-f3lp10lm	185	51	et	et	NNP
cord-301362-f3lp10lm	185	52	al	al	NNP
cord-301362-f3lp10lm	185	53	.	.	NNP
cord-301362-f3lp10lm	185	54	,	,	,
cord-301362-f3lp10lm	185	55	1996	1996	CD
cord-301362-f3lp10lm	185	56	;	;	:
cord-301362-f3lp10lm	185	57	Suhy	Suhy	NNP
cord-301362-f3lp10lm	185	58	et	et	FW
cord-301362-f3lp10lm	185	59	al	al	NNP
cord-301362-f3lp10lm	185	60	.	.	.
cord-301362-f3lp10lm	186	1	,	,	,
cord-301362-f3lp10lm	186	2	2000	2000	CD
cord-301362-f3lp10lm	186	3	,	,	,
cord-301362-f3lp10lm	186	4	please	please	UH
cord-301362-f3lp10lm	186	5	,	,	,
cord-301362-f3lp10lm	186	6	see	see	VB
cord-301362-f3lp10lm	186	7	below	below	RB
cord-301362-f3lp10lm	186	8	)	)	-RRB-
cord-301362-f3lp10lm	186	9	.	.	.
cord-301362-f3lp10lm	187	1	Regarding	regard	VBG
cord-301362-f3lp10lm	187	2	the	the	DT
cord-301362-f3lp10lm	187	3	participation	participation	NN
cord-301362-f3lp10lm	187	4	of	of	IN
cord-301362-f3lp10lm	187	5	host	host	NN
cord-301362-f3lp10lm	187	6	proteins	protein	NNS
cord-301362-f3lp10lm	187	7	it	-PRON-	PRP
cord-301362-f3lp10lm	187	8	was	be	VBD
cord-301362-f3lp10lm	187	9	found	find	VBN
cord-301362-f3lp10lm	187	10	that	that	IN
cord-301362-f3lp10lm	187	11	the	the	DT
cord-301362-f3lp10lm	187	12	Golgi	Golgi	NNP
cord-301362-f3lp10lm	187	13	-	-	HYPH
cord-301362-f3lp10lm	187	14	resident	resident	JJ
cord-301362-f3lp10lm	187	15	small	small	JJ
cord-301362-f3lp10lm	187	16	G	g	NN
cord-301362-f3lp10lm	187	17	protein	protein	NN
cord-301362-f3lp10lm	187	18	Arf1	arf1	NN
cord-301362-f3lp10lm	187	19	(	(	-LRB-
cord-301362-f3lp10lm	187	20	ADP	adp	NN
cord-301362-f3lp10lm	187	21	-	-	HYPH
cord-301362-f3lp10lm	187	22	ribosylation	ribosylation	NN
cord-301362-f3lp10lm	187	23	factor	factor	NN
cord-301362-f3lp10lm	187	24	)	)	-RRB-
cord-301362-f3lp10lm	187	25	,	,	,
cord-301362-f3lp10lm	187	26	as	as	RB
cord-301362-f3lp10lm	187	27	well	well	RB
cord-301362-f3lp10lm	187	28	as	as	IN
cord-301362-f3lp10lm	187	29	its	-PRON-	PRP$
cord-301362-f3lp10lm	187	30	activator	activator	NN
cord-301362-f3lp10lm	187	31	GBF1	GBF1	NNP
cord-301362-f3lp10lm	187	32	[	[	-LRB-
cord-301362-f3lp10lm	187	33	a	a	DT
cord-301362-f3lp10lm	187	34	guanine	guanine	NN
cord-301362-f3lp10lm	187	35	nucleotide	nucleotide	JJ
cord-301362-f3lp10lm	187	36	exchange	exchange	NN
cord-301362-f3lp10lm	187	37	factor	factor	NN
cord-301362-f3lp10lm	187	38	(	(	-LRB-
cord-301362-f3lp10lm	187	39	GEF	GEF	NNP
cord-301362-f3lp10lm	187	40	)	)	-RRB-
cord-301362-f3lp10lm	187	41	]	]	-RRB-
cord-301362-f3lp10lm	187	42	,	,	,
cord-301362-f3lp10lm	187	43	were	be	VBD
cord-301362-f3lp10lm	187	44	recruited	recruit	VBN
cord-301362-f3lp10lm	187	45	to	to	IN
cord-301362-f3lp10lm	187	46	sites	site	NNS
cord-301362-f3lp10lm	187	47	of	of	IN
cord-301362-f3lp10lm	187	48	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	187	49	replication	replication	NN
cord-301362-f3lp10lm	187	50	(	(	-LRB-
cord-301362-f3lp10lm	188	1	Belov	Belov	NNP
cord-301362-f3lp10lm	188	2	et	et	NNP
cord-301362-f3lp10lm	188	3	al	al	NNP
cord-301362-f3lp10lm	188	4	.	.	NNP
cord-301362-f3lp10lm	188	5	,	,	,
cord-301362-f3lp10lm	188	6	2005	2005	CD
cord-301362-f3lp10lm	188	7	)	)	-RRB-
cord-301362-f3lp10lm	188	8	.	.	.
cord-301362-f3lp10lm	189	1	It	-PRON-	PRP
cord-301362-f3lp10lm	189	2	is	be	VBZ
cord-301362-f3lp10lm	189	3	well	well	RB
cord-301362-f3lp10lm	189	4	known	know	VBN
cord-301362-f3lp10lm	189	5	that	that	IN
cord-301362-f3lp10lm	189	6	Arf1	Arf1	NNP
cord-301362-f3lp10lm	189	7	is	be	VBZ
cord-301362-f3lp10lm	189	8	critical	critical	JJ
cord-301362-f3lp10lm	189	9	for	for	IN
cord-301362-f3lp10lm	189	10	the	the	DT
cord-301362-f3lp10lm	189	11	proper	proper	JJ
cord-301362-f3lp10lm	189	12	functioning	functioning	NN
cord-301362-f3lp10lm	189	13	of	of	IN
cord-301362-f3lp10lm	189	14	the	the	DT
cord-301362-f3lp10lm	189	15	secretory	secretory	JJ
cord-301362-f3lp10lm	189	16	pathway	pathway	NN
cord-301362-f3lp10lm	189	17	,	,	,
cord-301362-f3lp10lm	189	18	thus	thus	RB
cord-301362-f3lp10lm	189	19	,	,	,
cord-301362-f3lp10lm	189	20	its	-PRON-	PRP$
cord-301362-f3lp10lm	189	21	translocation	translocation	NN
cord-301362-f3lp10lm	189	22	toward	toward	IN
cord-301362-f3lp10lm	189	23	the	the	DT
cord-301362-f3lp10lm	189	24	viral	viral	JJ
cord-301362-f3lp10lm	189	25	replication	replication	NN
cord-301362-f3lp10lm	189	26	complexes	complex	NNS
cord-301362-f3lp10lm	189	27	may	may	MD
cord-301362-f3lp10lm	189	28	account	account	VB
cord-301362-f3lp10lm	189	29	for	for	IN
cord-301362-f3lp10lm	189	30	the	the	DT
cord-301362-f3lp10lm	189	31	inhibition	inhibition	NN
cord-301362-f3lp10lm	189	32	of	of	IN
cord-301362-f3lp10lm	189	33	protein	protein	NN
cord-301362-f3lp10lm	189	34	secretion	secretion	NN
cord-301362-f3lp10lm	189	35	observed	observe	VBD
cord-301362-f3lp10lm	189	36	in	in	IN
cord-301362-f3lp10lm	189	37	infected	infect	VBN
cord-301362-f3lp10lm	189	38	-	-	HYPH
cord-301362-f3lp10lm	189	39	cells	cell	NNS
cord-301362-f3lp10lm	189	40	(	(	-LRB-
cord-301362-f3lp10lm	189	41	for	for	IN
cord-301362-f3lp10lm	189	42	a	a	DT
cord-301362-f3lp10lm	189	43	revision	revision	NN
cord-301362-f3lp10lm	189	44	see	see	VB
cord-301362-f3lp10lm	189	45	Belov	Belov	NNP
cord-301362-f3lp10lm	189	46	et	et	FW
cord-301362-f3lp10lm	189	47	al	al	NNP
cord-301362-f3lp10lm	189	48	.	.	NNP
cord-301362-f3lp10lm	189	49	,	,	,
cord-301362-f3lp10lm	189	50	2007	2007	CD
cord-301362-f3lp10lm	189	51	)	)	-RRB-
cord-301362-f3lp10lm	189	52	.	.	.
cord-301362-f3lp10lm	190	1	In	in	IN
cord-301362-f3lp10lm	190	2	addition	addition	NN
cord-301362-f3lp10lm	190	3	,	,	,
cord-301362-f3lp10lm	190	4	it	-PRON-	PRP
cord-301362-f3lp10lm	190	5	was	be	VBD
cord-301362-f3lp10lm	190	6	shown	show	VBN
cord-301362-f3lp10lm	190	7	that	that	IN
cord-301362-f3lp10lm	190	8	the	the	DT
cord-301362-f3lp10lm	190	9	release	release	NN
cord-301362-f3lp10lm	190	10	of	of	IN
cord-301362-f3lp10lm	190	11	COPII	COPII	NNP
cord-301362-f3lp10lm	190	12	-	-	HYPH
cord-301362-f3lp10lm	190	13	coated	coat	VBN
cord-301362-f3lp10lm	190	14	vesicles	vesicle	NNS
cord-301362-f3lp10lm	190	15	that	that	WDT
cord-301362-f3lp10lm	190	16	bud	bud	NN
cord-301362-f3lp10lm	190	17	from	from	IN
cord-301362-f3lp10lm	190	18	ERES	ERES	NNP
cord-301362-f3lp10lm	190	19	(	(	-LRB-
cord-301362-f3lp10lm	190	20	ER	ER	NNP
cord-301362-f3lp10lm	190	21	exit	exit	NN
cord-301362-f3lp10lm	190	22	sites	site	NNS
cord-301362-f3lp10lm	190	23	)	)	-RRB-
cord-301362-f3lp10lm	190	24	increases	increase	NNS
cord-301362-f3lp10lm	190	25	in	in	IN
cord-301362-f3lp10lm	190	26	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	190	27	-	-	HYPH
cord-301362-f3lp10lm	190	28	infected	infect	VBN
cord-301362-f3lp10lm	190	29	cells	cell	NNS
cord-301362-f3lp10lm	191	1	(	(	-LRB-
cord-301362-f3lp10lm	191	2	Trahey	Trahey	NNP
cord-301362-f3lp10lm	191	3	et	et	FW
cord-301362-f3lp10lm	191	4	al	al	NNP
cord-301362-f3lp10lm	191	5	.	.	NNP
cord-301362-f3lp10lm	191	6	,	,	,
cord-301362-f3lp10lm	191	7	2012	2012	CD
cord-301362-f3lp10lm	191	8	)	)	-RRB-
cord-301362-f3lp10lm	191	9	,	,	,
cord-301362-f3lp10lm	191	10	and	and	CC
cord-301362-f3lp10lm	191	11	that	that	DT
cord-301362-f3lp10lm	191	12	expression	expression	NN
cord-301362-f3lp10lm	191	13	of	of	IN
cord-301362-f3lp10lm	191	14	a	a	DT
cord-301362-f3lp10lm	191	15	dominant	dominant	JJ
cord-301362-f3lp10lm	191	16	negative	negative	JJ
cord-301362-f3lp10lm	191	17	mutant	mutant	NN
cord-301362-f3lp10lm	191	18	of	of	IN
cord-301362-f3lp10lm	191	19	the	the	DT
cord-301362-f3lp10lm	191	20	ER	ER	NNP
cord-301362-f3lp10lm	191	21	-	-	HYPH
cord-301362-f3lp10lm	191	22	resident	resident	NN
cord-301362-f3lp10lm	191	23	GTPase	GTPase	NNP
cord-301362-f3lp10lm	191	24	Sar1confirmed	sar1confirme	VBD
cord-301362-f3lp10lm	191	25	that	that	IN
cord-301362-f3lp10lm	191	26	PV	PV	NNP
cord-301362-f3lp10lm	191	27	requires	require	VBZ
cord-301362-f3lp10lm	191	28	functional	functional	JJ
cord-301362-f3lp10lm	191	29	ER	ER	NNP
cord-301362-f3lp10lm	191	30	exit	exit	NN
cord-301362-f3lp10lm	191	31	sites	site	NNS
cord-301362-f3lp10lm	191	32	for	for	IN
cord-301362-f3lp10lm	191	33	normal	normal	JJ
cord-301362-f3lp10lm	191	34	levels	level	NNS
cord-301362-f3lp10lm	191	35	of	of	IN
cord-301362-f3lp10lm	191	36	RNA	rna	NN
cord-301362-f3lp10lm	191	37	production	production	NN
cord-301362-f3lp10lm	191	38	and	and	CC
cord-301362-f3lp10lm	191	39	expression	expression	NN
cord-301362-f3lp10lm	192	1	(	(	-LRB-
cord-301362-f3lp10lm	192	2	Hsu	Hsu	NNP
cord-301362-f3lp10lm	192	3	et	et	NNP
cord-301362-f3lp10lm	192	4	al	al	NNP
cord-301362-f3lp10lm	192	5	.	.	NNP
cord-301362-f3lp10lm	192	6	,	,	,
cord-301362-f3lp10lm	192	7	2010	2010	CD
cord-301362-f3lp10lm	192	8	)	)	-RRB-
cord-301362-f3lp10lm	192	9	.	.	.
cord-301362-f3lp10lm	193	1	Both	both	DT
cord-301362-f3lp10lm	193	2	observations	observation	NNS
cord-301362-f3lp10lm	193	3	suggest	suggest	VBP
cord-301362-f3lp10lm	193	4	that	that	IN
cord-301362-f3lp10lm	193	5	the	the	DT
cord-301362-f3lp10lm	193	6	virus	virus	NN
cord-301362-f3lp10lm	193	7	replication	replication	NN
cord-301362-f3lp10lm	193	8	vesicles	vesicle	NNS
cord-301362-f3lp10lm	193	9	may	may	MD
cord-301362-f3lp10lm	193	10	be	be	VB
cord-301362-f3lp10lm	193	11	associated	associate	VBN
cord-301362-f3lp10lm	193	12	or	or	CC
cord-301362-f3lp10lm	193	13	derived	derive	VBN
cord-301362-f3lp10lm	193	14	from	from	IN
cord-301362-f3lp10lm	193	15	COPII	COPII	NNP
cord-301362-f3lp10lm	193	16	-	-	HYPH
cord-301362-f3lp10lm	193	17	vesicles	vesicle	NNS
cord-301362-f3lp10lm	193	18	.	.	.
cord-301362-f3lp10lm	194	1	However	however	RB
cord-301362-f3lp10lm	194	2	,	,	,
cord-301362-f3lp10lm	194	3	more	more	JJR
cord-301362-f3lp10lm	194	4	recent	recent	JJ
cord-301362-f3lp10lm	194	5	studies	study	NNS
cord-301362-f3lp10lm	194	6	indicate	indicate	VBP
cord-301362-f3lp10lm	194	7	that	that	IN
cord-301362-f3lp10lm	194	8	classical	classical	JJ
cord-301362-f3lp10lm	194	9	COPII	COPII	NNP
cord-301362-f3lp10lm	194	10	vesicles	vesicle	NNS
cord-301362-f3lp10lm	194	11	do	do	VBP
cord-301362-f3lp10lm	194	12	not	not	RB
cord-301362-f3lp10lm	194	13	seem	seem	VB
cord-301362-f3lp10lm	194	14	to	to	TO
cord-301362-f3lp10lm	194	15	be	be	VB
cord-301362-f3lp10lm	194	16	the	the	DT
cord-301362-f3lp10lm	194	17	site	site	NN
cord-301362-f3lp10lm	194	18	for	for	IN
cord-301362-f3lp10lm	194	19	RNA	RNA	NNP
cord-301362-f3lp10lm	194	20	replication	replication	NN
cord-301362-f3lp10lm	194	21	,	,	,
cord-301362-f3lp10lm	194	22	supporting	support	VBG
cord-301362-f3lp10lm	194	23	again	again	RB
cord-301362-f3lp10lm	194	24	the	the	DT
cord-301362-f3lp10lm	194	25	idea	idea	NN
cord-301362-f3lp10lm	194	26	that	that	IN
cord-301362-f3lp10lm	194	27	specialized	specialize	VBD
cord-301362-f3lp10lm	194	28	"	"	``
cord-301362-f3lp10lm	194	29	self	self	NN
cord-301362-f3lp10lm	194	30	-	-	HYPH
cord-301362-f3lp10lm	194	31	tailored	tailor	VBN
cord-301362-f3lp10lm	194	32	"	"	''
cord-301362-f3lp10lm	194	33	membrane	membrane	NN
cord-301362-f3lp10lm	194	34	vesicles	vesicle	NNS
cord-301362-f3lp10lm	194	35	are	be	VBP
cord-301362-f3lp10lm	194	36	involved	involve	VBN
cord-301362-f3lp10lm	194	37	in	in	IN
cord-301362-f3lp10lm	194	38	the	the	DT
cord-301362-f3lp10lm	194	39	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	194	40	factories	factory	NNS
cord-301362-f3lp10lm	194	41	.	.	.
cord-301362-f3lp10lm	195	1	The	the	DT
cord-301362-f3lp10lm	195	2	initial	initial	JJ
cord-301362-f3lp10lm	195	3	ultrastructural	ultrastructural	JJ
cord-301362-f3lp10lm	195	4	studies	study	NNS
cord-301362-f3lp10lm	195	5	of	of	IN
cord-301362-f3lp10lm	195	6	Dales	Dales	NNP
cord-301362-f3lp10lm	195	7	et	et	NNP
cord-301362-f3lp10lm	195	8	al	al	NNP
cord-301362-f3lp10lm	195	9	.	.	.
cord-301362-f3lp10lm	196	1	in	in	IN
cord-301362-f3lp10lm	196	2	1965	1965	CD
cord-301362-f3lp10lm	196	3	showed	show	VBD
cord-301362-f3lp10lm	196	4	a	a	DT
cord-301362-f3lp10lm	196	5	marked	marked	JJ
cord-301362-f3lp10lm	196	6	increase	increase	NN
cord-301362-f3lp10lm	196	7	in	in	IN
cord-301362-f3lp10lm	196	8	single	single	JJ
cord-301362-f3lp10lm	196	9	membrane	membrane	NN
cord-301362-f3lp10lm	196	10	vesicles	vesicle	NNS
cord-301362-f3lp10lm	196	11	at	at	IN
cord-301362-f3lp10lm	196	12	3	3	CD
cord-301362-f3lp10lm	196	13	h	h	NN
cord-301362-f3lp10lm	196	14	p.i	p.i	NNP
cord-301362-f3lp10lm	196	15	.	.	NNP
cord-301362-f3lp10lm	196	16	and	and	CC
cord-301362-f3lp10lm	196	17	double	double	JJ
cord-301362-f3lp10lm	196	18	-	-	HYPH
cord-301362-f3lp10lm	196	19	membrane	membrane	NN
cord-301362-f3lp10lm	196	20	structures	structure	NNS
cord-301362-f3lp10lm	196	21	associated	associate	VBN
cord-301362-f3lp10lm	196	22	to	to	IN
cord-301362-f3lp10lm	196	23	viral	viral	JJ
cord-301362-f3lp10lm	196	24	particles	particle	NNS
cord-301362-f3lp10lm	196	25	at	at	IN
cord-301362-f3lp10lm	196	26	7	7	CD
cord-301362-f3lp10lm	196	27	h	h	NN
cord-301362-f3lp10lm	196	28	p.i	p.i	NNP
cord-301362-f3lp10lm	196	29	.	.	NNP
cord-301362-f3lp10lm	196	30	,	,	,
cord-301362-f3lp10lm	196	31	suggesting	suggest	VBG
cord-301362-f3lp10lm	196	32	that	that	IN
cord-301362-f3lp10lm	196	33	autophagic	autophagic	NNP
cord-301362-f3lp10lm	196	34	vesicles	vesicle	NNS
cord-301362-f3lp10lm	196	35	are	be	VBP
cord-301362-f3lp10lm	196	36	involved	involve	VBN
cord-301362-f3lp10lm	196	37	in	in	IN
cord-301362-f3lp10lm	196	38	biogenesis	biogenesis	NN
cord-301362-f3lp10lm	196	39	of	of	IN
cord-301362-f3lp10lm	196	40	viral	viral	JJ
cord-301362-f3lp10lm	196	41	replication	replication	NN
cord-301362-f3lp10lm	196	42	factories	factory	NNS
cord-301362-f3lp10lm	196	43	(	(	-LRB-
cord-301362-f3lp10lm	196	44	Dales	Dales	NNP
cord-301362-f3lp10lm	196	45	et	et	NNP
cord-301362-f3lp10lm	196	46	al	al	NNP
cord-301362-f3lp10lm	196	47	.	.	NNP
cord-301362-f3lp10lm	196	48	,	,	,
cord-301362-f3lp10lm	196	49	1965	1965	CD
cord-301362-f3lp10lm	196	50	)	)	-RRB-
cord-301362-f3lp10lm	196	51	.	.	.
cord-301362-f3lp10lm	197	1	We	-PRON-	PRP
cord-301362-f3lp10lm	197	2	now	now	RB
cord-301362-f3lp10lm	197	3	know	know	VBP
cord-301362-f3lp10lm	197	4	that	that	IN
cord-301362-f3lp10lm	197	5	double	double	JJ
cord-301362-f3lp10lm	197	6	-	-	HYPH
cord-301362-f3lp10lm	197	7	membrane	membrane	NN
cord-301362-f3lp10lm	197	8	compartments	compartment	NNS
cord-301362-f3lp10lm	197	9	constitute	constitute	VBP
cord-301362-f3lp10lm	197	10	the	the	DT
cord-301362-f3lp10lm	197	11	hallmark	hallmark	JJ
cord-301362-f3lp10lm	197	12	vesicles	vesicle	NNS
cord-301362-f3lp10lm	197	13	of	of	IN
cord-301362-f3lp10lm	197	14	the	the	DT
cord-301362-f3lp10lm	197	15	constitutive	constitutive	JJ
cord-301362-f3lp10lm	197	16	degradative	degradative	NN
cord-301362-f3lp10lm	197	17	process	process	NN
cord-301362-f3lp10lm	197	18	known	know	VBN
cord-301362-f3lp10lm	197	19	as	as	IN
cord-301362-f3lp10lm	197	20	autophagy	autophagy	NN
cord-301362-f3lp10lm	197	21	,	,	,
cord-301362-f3lp10lm	197	22	or	or	CC
cord-301362-f3lp10lm	197	23	"	"	``
cord-301362-f3lp10lm	197	24	self	self	NN
cord-301362-f3lp10lm	197	25	-	-	HYPH
cord-301362-f3lp10lm	197	26	eating	eat	VBG
cord-301362-f3lp10lm	197	27	"	"	''
cord-301362-f3lp10lm	197	28	(	(	-LRB-
cord-301362-f3lp10lm	197	29	Schneider	Schneider	NNP
cord-301362-f3lp10lm	197	30	and	and	CC
cord-301362-f3lp10lm	197	31	Cuervo	Cuervo	NNP
cord-301362-f3lp10lm	197	32	,	,	,
cord-301362-f3lp10lm	197	33	2014	2014	CD
cord-301362-f3lp10lm	197	34	)	)	-RRB-
cord-301362-f3lp10lm	197	35	.	.	.
cord-301362-f3lp10lm	198	1	Autophagy	Autophagy	NNP
cord-301362-f3lp10lm	198	2	is	be	VBZ
cord-301362-f3lp10lm	198	3	an	an	DT
cord-301362-f3lp10lm	198	4	essential	essential	JJ
cord-301362-f3lp10lm	198	5	and	and	CC
cord-301362-f3lp10lm	198	6	constitutive	constitutive	JJ
cord-301362-f3lp10lm	198	7	cellular	cellular	JJ
cord-301362-f3lp10lm	198	8	process	process	NN
cord-301362-f3lp10lm	198	9	that	that	WDT
cord-301362-f3lp10lm	198	10	regulates	regulate	VBZ
cord-301362-f3lp10lm	198	11	turnover	turnover	NN
cord-301362-f3lp10lm	198	12	of	of	IN
cord-301362-f3lp10lm	198	13	organelles	organelle	NNS
cord-301362-f3lp10lm	198	14	,	,	,
cord-301362-f3lp10lm	198	15	lipid	lipid	NN
cord-301362-f3lp10lm	198	16	,	,	,
cord-301362-f3lp10lm	198	17	and	and	CC
cord-301362-f3lp10lm	198	18	proteins	protein	NNS
cord-301362-f3lp10lm	198	19	,	,	,
cord-301362-f3lp10lm	198	20	and	and	CC
cord-301362-f3lp10lm	198	21	plays	play	VBZ
cord-301362-f3lp10lm	198	22	a	a	DT
cord-301362-f3lp10lm	198	23	role	role	NN
cord-301362-f3lp10lm	198	24	in	in	IN
cord-301362-f3lp10lm	198	25	viral	viral	JJ
cord-301362-f3lp10lm	198	26	infections	infection	NNS
cord-301362-f3lp10lm	198	27	(	(	-LRB-
cord-301362-f3lp10lm	198	28	Shi	Shi	NNP
cord-301362-f3lp10lm	198	29	and	and	CC
cord-301362-f3lp10lm	198	30	Luo	Luo	NNP
cord-301362-f3lp10lm	198	31	,	,	,
cord-301362-f3lp10lm	198	32	2012	2012	CD
cord-301362-f3lp10lm	198	33	)	)	-RRB-
cord-301362-f3lp10lm	198	34	.	.	.
cord-301362-f3lp10lm	199	1	In	in	IN
cord-301362-f3lp10lm	199	2	later	later	JJ
cord-301362-f3lp10lm	199	3	studies	study	NNS
cord-301362-f3lp10lm	199	4	,	,	,
cord-301362-f3lp10lm	199	5	Kirkergaard	Kirkergaard	NNP
cord-301362-f3lp10lm	199	6	and	and	CC
cord-301362-f3lp10lm	199	7	collaborators	collaborator	NNS
cord-301362-f3lp10lm	199	8	were	be	VBD
cord-301362-f3lp10lm	199	9	able	able	JJ
cord-301362-f3lp10lm	199	10	to	to	TO
cord-301362-f3lp10lm	199	11	identify	identify	VB
cord-301362-f3lp10lm	199	12	,	,	,
cord-301362-f3lp10lm	199	13	using	use	VBG
cord-301362-f3lp10lm	199	14	a	a	DT
cord-301362-f3lp10lm	199	15	high	high	JJ
cord-301362-f3lp10lm	199	16	pressure	pressure	NN
cord-301362-f3lp10lm	199	17	freezing	freezing	NN
cord-301362-f3lp10lm	199	18	and	and	CC
cord-301362-f3lp10lm	199	19	freeze	freeze	VB
cord-301362-f3lp10lm	199	20	substitution	substitution	NN
cord-301362-f3lp10lm	199	21	technique	technique	NN
cord-301362-f3lp10lm	199	22	,	,	,
cord-301362-f3lp10lm	199	23	doublemembrane	doublemembrane	NNP
cord-301362-f3lp10lm	199	24	structures	structure	NNS
cord-301362-f3lp10lm	199	25	in	in	IN
cord-301362-f3lp10lm	199	26	infected	infected	JJ
cord-301362-f3lp10lm	199	27	COS-1	COS-1	NNP
cord-301362-f3lp10lm	199	28	cells	cell	NNS
cord-301362-f3lp10lm	199	29	at	at	IN
cord-301362-f3lp10lm	199	30	early	early	JJ
cord-301362-f3lp10lm	199	31	infection	infection	NN
cord-301362-f3lp10lm	199	32	time	time	NN
cord-301362-f3lp10lm	199	33	points	point	NNS
cord-301362-f3lp10lm	199	34	(	(	-LRB-
cord-301362-f3lp10lm	199	35	i.e.	i.e.	FW
cord-301362-f3lp10lm	199	36	,	,	,
cord-301362-f3lp10lm	199	37	4	4	CD
cord-301362-f3lp10lm	199	38	h	h	NN
cord-301362-f3lp10lm	199	39	p.i	p.i	NNP
cord-301362-f3lp10lm	199	40	.	.	.
cord-301362-f3lp10lm	199	41	)	)	-RRB-
cord-301362-f3lp10lm	200	1	(	(	-LRB-
cord-301362-f3lp10lm	200	2	Schlegel	Schlegel	NNP
cord-301362-f3lp10lm	200	3	et	et	NNP
cord-301362-f3lp10lm	200	4	al	al	NNP
cord-301362-f3lp10lm	200	5	.	.	NNP
cord-301362-f3lp10lm	200	6	,	,	,
cord-301362-f3lp10lm	200	7	1996	1996	CD
cord-301362-f3lp10lm	200	8	;	;	:
cord-301362-f3lp10lm	200	9	Suhy	Suhy	NNP
cord-301362-f3lp10lm	200	10	et	et	FW
cord-301362-f3lp10lm	200	11	al	al	NNP
cord-301362-f3lp10lm	200	12	.	.	NNP
cord-301362-f3lp10lm	200	13	,	,	,
cord-301362-f3lp10lm	200	14	2000	2000	CD
cord-301362-f3lp10lm	200	15	)	)	-RRB-
cord-301362-f3lp10lm	200	16	.	.	.
cord-301362-f3lp10lm	201	1	The	the	DT
cord-301362-f3lp10lm	201	2	virions	virion	NNS
cord-301362-f3lp10lm	201	3	were	be	VBD
cord-301362-f3lp10lm	201	4	in	in	IN
cord-301362-f3lp10lm	201	5	between	between	IN
cord-301362-f3lp10lm	201	6	clustered	clustered	JJ
cord-301362-f3lp10lm	201	7	vesicles	vesicle	NNS
cord-301362-f3lp10lm	201	8	and	and	CC
cord-301362-f3lp10lm	201	9	also	also	RB
cord-301362-f3lp10lm	201	10	within	within	IN
cord-301362-f3lp10lm	201	11	double	double	JJ
cord-301362-f3lp10lm	201	12	-	-	HYPH
cord-301362-f3lp10lm	201	13	membrane	membrane	NN
cord-301362-f3lp10lm	201	14	vesicles	vesicle	NNS
cord-301362-f3lp10lm	201	15	labeled	label	VBN
cord-301362-f3lp10lm	201	16	with	with	IN
cord-301362-f3lp10lm	201	17	the	the	DT
cord-301362-f3lp10lm	201	18	autophagic	autophagic	NNP
cord-301362-f3lp10lm	201	19	protein	protein	NN
cord-301362-f3lp10lm	201	20	LC3	LC3	NNP
cord-301362-f3lp10lm	201	21	where	where	WRB
cord-301362-f3lp10lm	201	22	RNA	RNA	NNP
cord-301362-f3lp10lm	201	23	replication	replication	NN
cord-301362-f3lp10lm	201	24	was	be	VBD
cord-301362-f3lp10lm	201	25	taking	take	VBG
cord-301362-f3lp10lm	201	26	place	place	NN
cord-301362-f3lp10lm	201	27	(	(	-LRB-
cord-301362-f3lp10lm	201	28	Belov	Belov	NNP
cord-301362-f3lp10lm	201	29	et	et	FW
cord-301362-f3lp10lm	201	30	al	al	NNP
cord-301362-f3lp10lm	201	31	.	.	NNP
cord-301362-f3lp10lm	201	32	,	,	,
cord-301362-f3lp10lm	201	33	2012	2012	CD
cord-301362-f3lp10lm	201	34	;	;	:
cord-301362-f3lp10lm	201	35	Richards	Richards	NNP
cord-301362-f3lp10lm	201	36	et	et	NNP
cord-301362-f3lp10lm	201	37	al	al	NNP
cord-301362-f3lp10lm	201	38	.	.	NNP
cord-301362-f3lp10lm	201	39	,	,	,
cord-301362-f3lp10lm	201	40	2014	2014	CD
cord-301362-f3lp10lm	201	41	)	)	-RRB-
cord-301362-f3lp10lm	201	42	.	.	.
cord-301362-f3lp10lm	202	1	Belov	Belov	NNP
cord-301362-f3lp10lm	202	2	and	and	CC
cord-301362-f3lp10lm	202	3	collaborators	collaborator	NNS
cord-301362-f3lp10lm	202	4	performed	perform	VBD
cord-301362-f3lp10lm	202	5	a	a	DT
cord-301362-f3lp10lm	202	6	threedimensional	threedimensional	JJ
cord-301362-f3lp10lm	202	7	analysis	analysis	NN
cord-301362-f3lp10lm	202	8	showing	show	VBG
cord-301362-f3lp10lm	202	9	that	that	WDT
cord-301362-f3lp10lm	202	10	indeed	indeed	RB
cord-301362-f3lp10lm	202	11	the	the	DT
cord-301362-f3lp10lm	202	12	vesicles	vesicle	NNS
cord-301362-f3lp10lm	202	13	seemed	seem	VBD
cord-301362-f3lp10lm	202	14	to	to	TO
cord-301362-f3lp10lm	202	15	be	be	VB
cord-301362-f3lp10lm	202	16	interconnected	interconnect	VBN
cord-301362-f3lp10lm	202	17	forming	form	VBG
cord-301362-f3lp10lm	202	18	a	a	DT
cord-301362-f3lp10lm	202	19	network	network	NN
cord-301362-f3lp10lm	202	20	of	of	IN
cord-301362-f3lp10lm	202	21	tubular	tubular	JJ
cord-301362-f3lp10lm	202	22	structures	structure	NNS
cord-301362-f3lp10lm	202	23	(	(	-LRB-
cord-301362-f3lp10lm	202	24	Belov	Belov	NNP
cord-301362-f3lp10lm	202	25	et	et	FW
cord-301362-f3lp10lm	202	26	al	al	NNP
cord-301362-f3lp10lm	202	27	.	.	NNP
cord-301362-f3lp10lm	202	28	,	,	,
cord-301362-f3lp10lm	202	29	2012	2012	CD
cord-301362-f3lp10lm	202	30	)	)	-RRB-
cord-301362-f3lp10lm	202	31	.	.	.
cord-301362-f3lp10lm	203	1	These	these	DT
cord-301362-f3lp10lm	203	2	recent	recent	JJ
cord-301362-f3lp10lm	203	3	studies	study	NNS
cord-301362-f3lp10lm	203	4	have	have	VBP
cord-301362-f3lp10lm	203	5	revealed	reveal	VBN
cord-301362-f3lp10lm	203	6	that	that	IN
cord-301362-f3lp10lm	203	7	the	the	DT
cord-301362-f3lp10lm	203	8	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	203	9	factories	factory	NNS
cord-301362-f3lp10lm	203	10	morphology	morphology	NN
cord-301362-f3lp10lm	203	11	are	be	VBP
cord-301362-f3lp10lm	203	12	indeed	indeed	RB
cord-301362-f3lp10lm	203	13	complex	complex	JJ
cord-301362-f3lp10lm	203	14	structures	structure	NNS
cord-301362-f3lp10lm	203	15	that	that	WDT
cord-301362-f3lp10lm	203	16	at	at	IN
cord-301362-f3lp10lm	203	17	early	early	JJ
cord-301362-f3lp10lm	203	18	times	time	NNS
cord-301362-f3lp10lm	203	19	p.i	p.i	NNP
cord-301362-f3lp10lm	203	20	.	.	NNP
cord-301362-f3lp10lm	203	21	consist	consist	VBP
cord-301362-f3lp10lm	203	22	in	in	IN
cord-301362-f3lp10lm	203	23	clusters	cluster	NNS
cord-301362-f3lp10lm	203	24	of	of	IN
cord-301362-f3lp10lm	203	25	single	single	JJ
cord-301362-f3lp10lm	203	26	membrane	membrane	NN
cord-301362-f3lp10lm	203	27	vesicles	vesicle	NNS
cord-301362-f3lp10lm	203	28	,	,	,
cord-301362-f3lp10lm	203	29	as	as	IN
cord-301362-f3lp10lm	203	30	previously	previously	RB
cord-301362-f3lp10lm	203	31	described	describe	VBN
cord-301362-f3lp10lm	203	32	by	by	IN
cord-301362-f3lp10lm	203	33	Dales	Dales	NNP
cord-301362-f3lp10lm	203	34	et	et	NNP
cord-301362-f3lp10lm	203	35	al	al	NNP
cord-301362-f3lp10lm	203	36	.	.	.
cord-301362-f3lp10lm	204	1	(	(	-LRB-
cord-301362-f3lp10lm	204	2	1965	1965	CD
cord-301362-f3lp10lm	204	3	)	)	-RRB-
cord-301362-f3lp10lm	205	1	but	but	CC
cord-301362-f3lp10lm	205	2	at	at	IN
cord-301362-f3lp10lm	205	3	later	later	RB
cord-301362-f3lp10lm	205	4	times	time	NNS
cord-301362-f3lp10lm	205	5	p.i	p.i	NNP
cord-301362-f3lp10lm	205	6	.	.	.
cord-301362-f3lp10lm	205	7	most	most	JJS
cord-301362-f3lp10lm	205	8	of	of	IN
cord-301362-f3lp10lm	205	9	them	-PRON-	PRP
cord-301362-f3lp10lm	205	10	are	be	VBP
cord-301362-f3lp10lm	205	11	compose	compose	VBN
cord-301362-f3lp10lm	205	12	by	by	IN
cord-301362-f3lp10lm	205	13	double	double	JJ
cord-301362-f3lp10lm	205	14	membrane	membrane	NN
cord-301362-f3lp10lm	205	15	vesicles	vesicle	NNS
cord-301362-f3lp10lm	205	16	and	and	CC
cord-301362-f3lp10lm	205	17	that	that	IN
cord-301362-f3lp10lm	205	18	some	some	DT
cord-301362-f3lp10lm	205	19	of	of	IN
cord-301362-f3lp10lm	205	20	these	these	DT
cord-301362-f3lp10lm	205	21	double	double	JJ
cord-301362-f3lp10lm	205	22	membrane	membrane	NN
cord-301362-f3lp10lm	205	23	structures	structure	NNS
cord-301362-f3lp10lm	205	24	are	be	VBP
cord-301362-f3lp10lm	205	25	not	not	RB
cord-301362-f3lp10lm	205	26	completely	completely	RB
cord-301362-f3lp10lm	205	27	closed	closed	JJ
cord-301362-f3lp10lm	205	28	.	.	.
cord-301362-f3lp10lm	206	1	These	these	DT
cord-301362-f3lp10lm	206	2	structures	structure	NNS
cord-301362-f3lp10lm	206	3	may	may	MD
cord-301362-f3lp10lm	206	4	serve	serve	VB
cord-301362-f3lp10lm	206	5	to	to	TO
cord-301362-f3lp10lm	206	6	protect	protect	VB
cord-301362-f3lp10lm	206	7	double	double	RB
cord-301362-f3lp10lm	206	8	-	-	HYPH
cord-301362-f3lp10lm	206	9	stranded	strand	VBN
cord-301362-f3lp10lm	206	10	RNA	RNA	NNP
cord-301362-f3lp10lm	206	11	intermediates	intermediate	NNS
cord-301362-f3lp10lm	206	12	during	during	IN
cord-301362-f3lp10lm	206	13	RNA	RNA	NNP
cord-301362-f3lp10lm	206	14	replication	replication	NN
cord-301362-f3lp10lm	206	15	(	(	-LRB-
cord-301362-f3lp10lm	206	16	for	for	IN
cord-301362-f3lp10lm	206	17	a	a	DT
cord-301362-f3lp10lm	206	18	comprehensive	comprehensive	JJ
cord-301362-f3lp10lm	206	19	review	review	NN
cord-301362-f3lp10lm	206	20	see	see	VBP
cord-301362-f3lp10lm	206	21	Rossignol	Rossignol	NNP
cord-301362-f3lp10lm	206	22	et	et	NNP
cord-301362-f3lp10lm	206	23	al	al	NNP
cord-301362-f3lp10lm	206	24	.	.	NNP
cord-301362-f3lp10lm	206	25	,	,	,
cord-301362-f3lp10lm	206	26	2015	2015	CD
cord-301362-f3lp10lm	206	27	)	)	-RRB-
cord-301362-f3lp10lm	206	28	.	.	.
cord-301362-f3lp10lm	207	1	The	the	DT
cord-301362-f3lp10lm	207	2	Kikergaard	Kikergaard	NNP
cord-301362-f3lp10lm	207	3	's	's	POS
cord-301362-f3lp10lm	207	4	group	group	NN
cord-301362-f3lp10lm	207	5	was	be	VBD
cord-301362-f3lp10lm	207	6	the	the	DT
cord-301362-f3lp10lm	207	7	first	first	JJ
cord-301362-f3lp10lm	207	8	demonstrating	demonstrate	VBG
cord-301362-f3lp10lm	207	9	that	that	IN
cord-301362-f3lp10lm	207	10	autophagy	autophagy	NN
cord-301362-f3lp10lm	207	11	benefit	benefit	NN
cord-301362-f3lp10lm	207	12	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	207	13	replication	replication	NN
cord-301362-f3lp10lm	207	14	since	since	IN
cord-301362-f3lp10lm	207	15	treatment	treatment	NN
cord-301362-f3lp10lm	207	16	with	with	IN
cord-301362-f3lp10lm	207	17	autophagy	autophagy	NN
cord-301362-f3lp10lm	207	18	inducers	inducer	NNS
cord-301362-f3lp10lm	207	19	such	such	JJ
cord-301362-f3lp10lm	207	20	as	as	IN
cord-301362-f3lp10lm	207	21	rapamycin	rapamycin	NN
cord-301362-f3lp10lm	207	22	increased	increase	VBD
cord-301362-f3lp10lm	207	23	viral	viral	JJ
cord-301362-f3lp10lm	207	24	particles	particle	NNS
cord-301362-f3lp10lm	207	25	production	production	NN
cord-301362-f3lp10lm	207	26	(	(	-LRB-
cord-301362-f3lp10lm	207	27	Jackson	Jackson	NNP
cord-301362-f3lp10lm	207	28	et	et	NNP
cord-301362-f3lp10lm	207	29	al	al	NNP
cord-301362-f3lp10lm	207	30	.	.	NNP
cord-301362-f3lp10lm	207	31	,	,	,
cord-301362-f3lp10lm	207	32	2005	2005	CD
cord-301362-f3lp10lm	207	33	)	)	-RRB-
cord-301362-f3lp10lm	207	34	.	.	.
cord-301362-f3lp10lm	208	1	In	in	IN
cord-301362-f3lp10lm	208	2	addition	addition	NN
cord-301362-f3lp10lm	208	3	,	,	,
cord-301362-f3lp10lm	208	4	it	-PRON-	PRP
cord-301362-f3lp10lm	208	5	was	be	VBD
cord-301362-f3lp10lm	208	6	also	also	RB
cord-301362-f3lp10lm	208	7	shown	show	VBN
cord-301362-f3lp10lm	208	8	that	that	IN
cord-301362-f3lp10lm	208	9	viruses	virus	NNS
cord-301362-f3lp10lm	208	10	traffic	traffic	NN
cord-301362-f3lp10lm	208	11	into	into	IN
cord-301362-f3lp10lm	208	12	the	the	DT
cord-301362-f3lp10lm	208	13	mature	mature	JJ
cord-301362-f3lp10lm	208	14	acidic	acidic	JJ
cord-301362-f3lp10lm	208	15	autophagic	autophagic	NN
cord-301362-f3lp10lm	208	16	vesicles	vesicle	NNS
cord-301362-f3lp10lm	208	17	and	and	CC
cord-301362-f3lp10lm	208	18	that	that	IN
cord-301362-f3lp10lm	208	19	maturation	maturation	NN
cord-301362-f3lp10lm	208	20	of	of	IN
cord-301362-f3lp10lm	208	21	infectious	infectious	JJ
cord-301362-f3lp10lm	208	22	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	208	23	particles	particle	NNS
cord-301362-f3lp10lm	208	24	requires	require	VBZ
cord-301362-f3lp10lm	208	25	intracellular	intracellular	JJ
cord-301362-f3lp10lm	208	26	vesicle	vesicle	NN
cord-301362-f3lp10lm	208	27	acidification	acidification	NN
cord-301362-f3lp10lm	208	28	(	(	-LRB-
cord-301362-f3lp10lm	208	29	Richards	Richards	NNP
cord-301362-f3lp10lm	208	30	and	and	CC
cord-301362-f3lp10lm	208	31	Jackson	Jackson	NNP
cord-301362-f3lp10lm	208	32	,	,	,
cord-301362-f3lp10lm	208	33	2012	2012	CD
cord-301362-f3lp10lm	208	34	)	)	-RRB-
cord-301362-f3lp10lm	208	35	.	.	.
cord-301362-f3lp10lm	209	1	Cumulative	cumulative	JJ
cord-301362-f3lp10lm	209	2	evidence	evidence	NN
cord-301362-f3lp10lm	209	3	indicate	indicate	VBP
cord-301362-f3lp10lm	209	4	that	that	IN
cord-301362-f3lp10lm	209	5	polioviruses	poliovirus	NNS
cord-301362-f3lp10lm	209	6	hijack	hijack	VBP
cord-301362-f3lp10lm	209	7	autophagic	autophagic	NN
cord-301362-f3lp10lm	209	8	components	component	NNS
cord-301362-f3lp10lm	209	9	to	to	TO
cord-301362-f3lp10lm	209	10	allow	allow	VB
cord-301362-f3lp10lm	209	11	their	-PRON-	PRP$
cord-301362-f3lp10lm	209	12	assembly	assembly	NN
cord-301362-f3lp10lm	209	13	,	,	,
cord-301362-f3lp10lm	209	14	maturation	maturation	NN
cord-301362-f3lp10lm	209	15	and	and	CC
cord-301362-f3lp10lm	209	16	exit	exit	NN
cord-301362-f3lp10lm	209	17	from	from	IN
cord-301362-f3lp10lm	209	18	the	the	DT
cord-301362-f3lp10lm	209	19	host	host	NN
cord-301362-f3lp10lm	209	20	cell	cell	NN
cord-301362-f3lp10lm	209	21	,	,	,
cord-301362-f3lp10lm	209	22	via	via	IN
cord-301362-f3lp10lm	209	23	a	a	DT
cord-301362-f3lp10lm	209	24	process	process	NN
cord-301362-f3lp10lm	209	25	known	know	VBN
cord-301362-f3lp10lm	209	26	as	as	IN
cord-301362-f3lp10lm	209	27	AWOL	AWOL	NNP
cord-301362-f3lp10lm	210	1	(	(	-LRB-
cord-301362-f3lp10lm	210	2	Autophagosome	Autophagosome	NNP
cord-301362-f3lp10lm	210	3	mediated	mediate	VBN
cord-301362-f3lp10lm	210	4	exit	exit	NN
cord-301362-f3lp10lm	210	5	without	without	IN
cord-301362-f3lp10lm	210	6	cell	cell	NN
cord-301362-f3lp10lm	210	7	lysis	lysis	NN
cord-301362-f3lp10lm	210	8	)	)	-RRB-
cord-301362-f3lp10lm	211	1	(	(	-LRB-
cord-301362-f3lp10lm	211	2	Arita	Arita	NNP
cord-301362-f3lp10lm	211	3	et	et	FW
cord-301362-f3lp10lm	211	4	al	al	NNP
cord-301362-f3lp10lm	211	5	.	.	NNP
cord-301362-f3lp10lm	211	6	,	,	,
cord-301362-f3lp10lm	211	7	2012	2012	CD
cord-301362-f3lp10lm	211	8	)	)	-RRB-
cord-301362-f3lp10lm	211	9	.	.	.
cord-301362-f3lp10lm	212	1	It	-PRON-	PRP
cord-301362-f3lp10lm	212	2	has	have	VBZ
cord-301362-f3lp10lm	212	3	been	be	VBN
cord-301362-f3lp10lm	212	4	shown	show	VBN
cord-301362-f3lp10lm	212	5	that	that	IN
cord-301362-f3lp10lm	212	6	LC3	lc3	JJ
cord-301362-f3lp10lm	212	7	silencing	silence	VBG
cord-301362-f3lp10lm	212	8	with	with	IN
cord-301362-f3lp10lm	212	9	a	a	DT
cord-301362-f3lp10lm	212	10	siRNA	siRNA	NNP
cord-301362-f3lp10lm	212	11	leads	lead	VBZ
cord-301362-f3lp10lm	212	12	to	to	IN
cord-301362-f3lp10lm	212	13	a	a	DT
cord-301362-f3lp10lm	212	14	decrease	decrease	NN
cord-301362-f3lp10lm	212	15	of	of	IN
cord-301362-f3lp10lm	212	16	viral	viral	JJ
cord-301362-f3lp10lm	212	17	cell	cell	NN
cord-301362-f3lp10lm	212	18	-	-	HYPH
cord-301362-f3lp10lm	212	19	to	to	IN
cord-301362-f3lp10lm	212	20	-	-	HYPH
cord-301362-f3lp10lm	212	21	cell	cell	NN
cord-301362-f3lp10lm	212	22	spread	spread	NN
cord-301362-f3lp10lm	212	23	whereas	whereas	IN
cord-301362-f3lp10lm	212	24	autophagy	autophagy	NN
cord-301362-f3lp10lm	212	25	induction	induction	NN
cord-301362-f3lp10lm	212	26	favors	favor	VBZ
cord-301362-f3lp10lm	212	27	this	this	DT
cord-301362-f3lp10lm	212	28	non	non	JJ
cord-301362-f3lp10lm	212	29	-	-	JJ
cord-301362-f3lp10lm	212	30	lytic	lytic	JJ
cord-301362-f3lp10lm	212	31	release	release	NN
cord-301362-f3lp10lm	212	32	in	in	IN
cord-301362-f3lp10lm	212	33	both	both	DT
cord-301362-f3lp10lm	212	34	cultured	cultured	JJ
cord-301362-f3lp10lm	212	35	cells	cell	NNS
cord-301362-f3lp10lm	212	36	and	and	CC
cord-301362-f3lp10lm	212	37	mice	mouse	NNS
cord-301362-f3lp10lm	212	38	(	(	-LRB-
cord-301362-f3lp10lm	212	39	Bird	Bird	NNP
cord-301362-f3lp10lm	212	40	et	et	NNP
cord-301362-f3lp10lm	212	41	al	al	NNP
cord-301362-f3lp10lm	212	42	.	.	NNP
cord-301362-f3lp10lm	212	43	,	,	,
cord-301362-f3lp10lm	212	44	2014	2014	CD
cord-301362-f3lp10lm	212	45	)	)	-RRB-
cord-301362-f3lp10lm	212	46	.	.	.
cord-301362-f3lp10lm	213	1	The	the	DT
cord-301362-f3lp10lm	213	2	release	release	NN
cord-301362-f3lp10lm	213	3	of	of	IN
cord-301362-f3lp10lm	213	4	viral	viral	JJ
cord-301362-f3lp10lm	213	5	particles	particle	NNS
cord-301362-f3lp10lm	213	6	via	via	IN
cord-301362-f3lp10lm	213	7	a	a	DT
cord-301362-f3lp10lm	213	8	non	non	JJ
cord-301362-f3lp10lm	213	9	-	-	JJ
cord-301362-f3lp10lm	213	10	lytic	lytic	JJ
cord-301362-f3lp10lm	213	11	process	process	NN
cord-301362-f3lp10lm	213	12	was	be	VBD
cord-301362-f3lp10lm	213	13	also	also	RB
cord-301362-f3lp10lm	213	14	previously	previously	RB
cord-301362-f3lp10lm	213	15	suggested	suggest	VBN
cord-301362-f3lp10lm	213	16	by	by	IN
cord-301362-f3lp10lm	213	17	a	a	DT
cord-301362-f3lp10lm	213	18	study	study	NN
cord-301362-f3lp10lm	213	19	in	in	IN
cord-301362-f3lp10lm	213	20	the	the	DT
cord-301362-f3lp10lm	213	21	spinal	spinal	JJ
cord-301362-f3lp10lm	213	22	cords	cord	NNS
cord-301362-f3lp10lm	213	23	of	of	IN
cord-301362-f3lp10lm	213	24	bonnet	bonnet	NN
cord-301362-f3lp10lm	213	25	monkeys	monkey	NNS
cord-301362-f3lp10lm	214	1	(	(	-LRB-
cord-301362-f3lp10lm	214	2	Ponnuraj	Ponnuraj	NNP
cord-301362-f3lp10lm	214	3	et	et	NNP
cord-301362-f3lp10lm	214	4	al	al	NNP
cord-301362-f3lp10lm	214	5	.	.	NNP
cord-301362-f3lp10lm	214	6	,	,	,
cord-301362-f3lp10lm	214	7	1998	1998	CD
cord-301362-f3lp10lm	214	8	)	)	-RRB-
cord-301362-f3lp10lm	214	9	.	.	.
cord-301362-f3lp10lm	215	1	In	in	IN
cord-301362-f3lp10lm	215	2	a	a	DT
cord-301362-f3lp10lm	215	3	recent	recent	JJ
cord-301362-f3lp10lm	215	4	publication	publication	NN
cord-301362-f3lp10lm	215	5	it	-PRON-	PRP
cord-301362-f3lp10lm	215	6	was	be	VBD
cord-301362-f3lp10lm	215	7	also	also	RB
cord-301362-f3lp10lm	215	8	shown	show	VBN
cord-301362-f3lp10lm	215	9	the	the	DT
cord-301362-f3lp10lm	215	10	release	release	NN
cord-301362-f3lp10lm	215	11	of	of	IN
cord-301362-f3lp10lm	215	12	enwrapped	enwrapped	NNP
cord-301362-f3lp10lm	215	13	virus	virus	NN
cord-301362-f3lp10lm	215	14	via	via	IN
cord-301362-f3lp10lm	215	15	autophagosomallike	autophagosomallike	NN
cord-301362-f3lp10lm	215	16	vesicles	vesicle	NNS
cord-301362-f3lp10lm	215	17	,	,	,
cord-301362-f3lp10lm	215	18	enriched	enrich	VBN
cord-301362-f3lp10lm	215	19	in	in	IN
cord-301362-f3lp10lm	215	20	phosphatidylserine	phosphatidylserine	NN
cord-301362-f3lp10lm	215	21	,	,	,
cord-301362-f3lp10lm	215	22	which	which	WDT
cord-301362-f3lp10lm	215	23	were	be	VBD
cord-301362-f3lp10lm	215	24	highly	highly	RB
cord-301362-f3lp10lm	215	25	efficient	efficient	JJ
cord-301362-f3lp10lm	215	26	in	in	IN
cord-301362-f3lp10lm	215	27	infection	infection	NN
cord-301362-f3lp10lm	216	1	(	(	-LRB-
cord-301362-f3lp10lm	216	2	Chen	Chen	NNP
cord-301362-f3lp10lm	216	3	et	et	NNP
cord-301362-f3lp10lm	216	4	al	al	NNP
cord-301362-f3lp10lm	216	5	.	.	NNP
cord-301362-f3lp10lm	216	6	,	,	,
cord-301362-f3lp10lm	216	7	2015	2015	CD
cord-301362-f3lp10lm	216	8	)	)	-RRB-
cord-301362-f3lp10lm	216	9	.	.	.
cord-301362-f3lp10lm	217	1	Other	other	JJ
cord-301362-f3lp10lm	217	2	+	+	CC
cord-301362-f3lp10lm	218	1	sRNA	srna	NN
cord-301362-f3lp10lm	218	2	viruses	virus	NNS
cord-301362-f3lp10lm	218	3	such	such	JJ
cord-301362-f3lp10lm	218	4	as	as	IN
cord-301362-f3lp10lm	218	5	the	the	DT
cord-301362-f3lp10lm	218	6	enterovirus	enterovirus	NN
cord-301362-f3lp10lm	218	7	Coxsackievirus	Coxsackievirus	NNP
cord-301362-f3lp10lm	218	8	(	(	-LRB-
cord-301362-f3lp10lm	218	9	Kemball	Kemball	NNP
cord-301362-f3lp10lm	218	10	et	et	FW
cord-301362-f3lp10lm	218	11	al	al	NNP
cord-301362-f3lp10lm	218	12	.	.	NNP
cord-301362-f3lp10lm	218	13	,	,	,
cord-301362-f3lp10lm	218	14	2010	2010	CD
cord-301362-f3lp10lm	218	15	)	)	-RRB-
cord-301362-f3lp10lm	218	16	,	,	,
cord-301362-f3lp10lm	218	17	Hepatitis	Hepatitis	NNP
cord-301362-f3lp10lm	218	18	C	C	NNP
cord-301362-f3lp10lm	218	19	virus	virus	NN
cord-301362-f3lp10lm	218	20	(	(	-LRB-
cord-301362-f3lp10lm	218	21	Flaviviridae	Flaviviridae	NNP
cord-301362-f3lp10lm	218	22	family	family	NN
cord-301362-f3lp10lm	218	23	)	)	-RRB-
cord-301362-f3lp10lm	219	1	(	(	-LRB-
cord-301362-f3lp10lm	219	2	Sir	Sir	NNP
cord-301362-f3lp10lm	219	3	et	et	NNP
cord-301362-f3lp10lm	219	4	al	al	NNP
cord-301362-f3lp10lm	219	5	.	.	NNP
cord-301362-f3lp10lm	219	6	,	,	,
cord-301362-f3lp10lm	219	7	2012	2012	CD
cord-301362-f3lp10lm	219	8	)	)	-RRB-
cord-301362-f3lp10lm	219	9	,	,	,
cord-301362-f3lp10lm	219	10	or	or	CC
cord-301362-f3lp10lm	219	11	Coronavirus	Coronavirus	NNP
cord-301362-f3lp10lm	219	12	such	such	JJ
cord-301362-f3lp10lm	219	13	as	as	IN
cord-301362-f3lp10lm	219	14	MVH	MVH	NNP
cord-301362-f3lp10lm	219	15	(	(	-LRB-
cord-301362-f3lp10lm	219	16	Reggiori	Reggiori	NNP
cord-301362-f3lp10lm	219	17	et	et	NNP
cord-301362-f3lp10lm	219	18	al	al	NNP
cord-301362-f3lp10lm	219	19	.	.	NNP
cord-301362-f3lp10lm	219	20	,	,	,
cord-301362-f3lp10lm	219	21	2010	2010	CD
cord-301362-f3lp10lm	219	22	)	)	-RRB-
cord-301362-f3lp10lm	219	23	also	also	RB
cord-301362-f3lp10lm	219	24	usurp	usurp	VBP
cord-301362-f3lp10lm	219	25	the	the	DT
cord-301362-f3lp10lm	219	26	autophagy	autophagy	NN
cord-301362-f3lp10lm	219	27	pathway	pathway	NN
cord-301362-f3lp10lm	219	28	and	and	CC
cord-301362-f3lp10lm	219	29	induce	induce	VB
cord-301362-f3lp10lm	219	30	remarkably	remarkably	RB
cord-301362-f3lp10lm	219	31	alterations	alteration	NNS
cord-301362-f3lp10lm	219	32	in	in	IN
cord-301362-f3lp10lm	219	33	intracellular	intracellular	JJ
cord-301362-f3lp10lm	219	34	membranous	membranous	JJ
cord-301362-f3lp10lm	219	35	components	component	NNS
cord-301362-f3lp10lm	219	36	to	to	TO
cord-301362-f3lp10lm	219	37	harbor	harbor	VB
cord-301362-f3lp10lm	219	38	the	the	DT
cord-301362-f3lp10lm	219	39	sites	site	NNS
cord-301362-f3lp10lm	219	40	for	for	IN
cord-301362-f3lp10lm	219	41	viral	viral	JJ
cord-301362-f3lp10lm	219	42	RNA	RNA	NNP
cord-301362-f3lp10lm	219	43	replication	replication	NN
cord-301362-f3lp10lm	219	44	.	.	.
cord-301362-f3lp10lm	220	1	However	however	RB
cord-301362-f3lp10lm	220	2	,	,	,
cord-301362-f3lp10lm	220	3	it	-PRON-	PRP
cord-301362-f3lp10lm	220	4	is	be	VBZ
cord-301362-f3lp10lm	220	5	important	important	JJ
cord-301362-f3lp10lm	220	6	to	to	TO
cord-301362-f3lp10lm	220	7	take	take	VB
cord-301362-f3lp10lm	220	8	into	into	IN
cord-301362-f3lp10lm	220	9	account	account	NN
cord-301362-f3lp10lm	220	10	that	that	IN
cord-301362-f3lp10lm	220	11	significant	significant	JJ
cord-301362-f3lp10lm	220	12	differences	difference	NNS
cord-301362-f3lp10lm	220	13	emerge	emerge	VBP
cord-301362-f3lp10lm	220	14	in	in	IN
cord-301362-f3lp10lm	220	15	the	the	DT
cord-301362-f3lp10lm	220	16	mode	mode	NN
cord-301362-f3lp10lm	220	17	that	that	WDT
cord-301362-f3lp10lm	220	18	different	different	JJ
cord-301362-f3lp10lm	220	19	virus	virus	NN
cord-301362-f3lp10lm	220	20	hijack	hijack	VBP
cord-301362-f3lp10lm	220	21	cellular	cellular	JJ
cord-301362-f3lp10lm	220	22	components	component	NNS
cord-301362-f3lp10lm	220	23	to	to	TO
cord-301362-f3lp10lm	220	24	establish	establish	VB
cord-301362-f3lp10lm	220	25	their	-PRON-	PRP$
cord-301362-f3lp10lm	220	26	replication	replication	NN
cord-301362-f3lp10lm	220	27	niches	niche	NNS
cord-301362-f3lp10lm	220	28	(	(	-LRB-
cord-301362-f3lp10lm	220	29	for	for	IN
cord-301362-f3lp10lm	220	30	more	more	JJR
cord-301362-f3lp10lm	220	31	comprehensive	comprehensive	JJ
cord-301362-f3lp10lm	220	32	revisions	revision	NNS
cord-301362-f3lp10lm	220	33	see	see	VBP
cord-301362-f3lp10lm	220	34	Paul	Paul	NNP
cord-301362-f3lp10lm	220	35	and	and	CC
cord-301362-f3lp10lm	220	36	Bartenschlager	Bartenschlager	NNP
cord-301362-f3lp10lm	220	37	,	,	,
cord-301362-f3lp10lm	220	38	2013	2013	CD
cord-301362-f3lp10lm	220	39	;	;	:
cord-301362-f3lp10lm	220	40	Harak	Harak	NNP
cord-301362-f3lp10lm	220	41	and	and	CC
cord-301362-f3lp10lm	220	42	Lohmann	Lohmann	NNP
cord-301362-f3lp10lm	220	43	,	,	,
cord-301362-f3lp10lm	220	44	2015	2015	CD
cord-301362-f3lp10lm	220	45	)	)	-RRB-
cord-301362-f3lp10lm	220	46	.	.	.
cord-301362-f3lp10lm	221	1	Using	use	VBG
cord-301362-f3lp10lm	221	2	Semliki	Semliki	NNP
cord-301362-f3lp10lm	221	3	Forest	Forest	NNP
cord-301362-f3lp10lm	221	4	Virus	Virus	NNP
cord-301362-f3lp10lm	221	5	(	(	-LRB-
cord-301362-f3lp10lm	221	6	SFV	SFV	NNP
cord-301362-f3lp10lm	221	7	)	)	-RRB-
cord-301362-f3lp10lm	221	8	as	as	IN
cord-301362-f3lp10lm	221	9	a	a	DT
cord-301362-f3lp10lm	221	10	prototype	prototype	NN
cord-301362-f3lp10lm	221	11	to	to	TO
cord-301362-f3lp10lm	221	12	analyze	analyze	VB
cord-301362-f3lp10lm	221	13	the	the	DT
cord-301362-f3lp10lm	221	14	innate	innate	JJ
cord-301362-f3lp10lm	221	15	immune	immune	JJ
cord-301362-f3lp10lm	221	16	response	response	NN
cord-301362-f3lp10lm	221	17	of	of	IN
cord-301362-f3lp10lm	221	18	host	host	NN
cord-301362-f3lp10lm	221	19	-	-	HYPH
cord-301362-f3lp10lm	221	20	cell	cell	NN
cord-301362-f3lp10lm	221	21	to	to	IN
cord-301362-f3lp10lm	221	22	+	+	SYM
cord-301362-f3lp10lm	221	23	sRNA	srna	NN
cord-301362-f3lp10lm	221	24	viruses	virus	NNS
cord-301362-f3lp10lm	221	25	,	,	,
cord-301362-f3lp10lm	221	26	Nikonov	Nikonov	NNP
cord-301362-f3lp10lm	221	27	et	et	NNP
cord-301362-f3lp10lm	221	28	al	al	NNP
cord-301362-f3lp10lm	221	29	.	.	.
cord-301362-f3lp10lm	222	1	(	(	-LRB-
cord-301362-f3lp10lm	222	2	2013	2013	CD
cord-301362-f3lp10lm	222	3	)	)	-RRB-
cord-301362-f3lp10lm	222	4	have	have	VBP
cord-301362-f3lp10lm	222	5	conspicuously	conspicuously	RB
cord-301362-f3lp10lm	222	6	described	describe	VBN
cord-301362-f3lp10lm	222	7	and	and	CC
cord-301362-f3lp10lm	222	8	proposed	propose	VBN
cord-301362-f3lp10lm	222	9	a	a	DT
cord-301362-f3lp10lm	222	10	novel	novel	JJ
cord-301362-f3lp10lm	222	11	mechanism	mechanism	NN
cord-301362-f3lp10lm	222	12	of	of	IN
cord-301362-f3lp10lm	222	13	action	action	NN
cord-301362-f3lp10lm	222	14	for	for	IN
cord-301362-f3lp10lm	222	15	type	type	NN
cord-301362-f3lp10lm	222	16	I	-PRON-	PRP
cord-301362-f3lp10lm	222	17	interferons	interferon	NNS
cord-301362-f3lp10lm	222	18	induction	induction	VBP
cord-301362-f3lp10lm	222	19	upon	upon	IN
cord-301362-f3lp10lm	222	20	RdPp	rdpp	NN
cord-301362-f3lp10lm	222	21	activity	activity	NN
cord-301362-f3lp10lm	222	22	detection	detection	NN
cord-301362-f3lp10lm	222	23	inside	inside	IN
cord-301362-f3lp10lm	222	24	the	the	DT
cord-301362-f3lp10lm	222	25	cell	cell	NN
cord-301362-f3lp10lm	222	26	.	.	.
cord-301362-f3lp10lm	223	1	Based	base	VBN
cord-301362-f3lp10lm	223	2	on	on	IN
cord-301362-f3lp10lm	223	3	previous	previous	JJ
cord-301362-f3lp10lm	223	4	observations	observation	NNS
cord-301362-f3lp10lm	223	5	that	that	DT
cord-301362-f3lp10lm	223	6	expression	expression	NN
cord-301362-f3lp10lm	223	7	of	of	IN
cord-301362-f3lp10lm	223	8	the	the	DT
cord-301362-f3lp10lm	223	9	viral	viral	JJ
cord-301362-f3lp10lm	223	10	replicase	replicase	NN
cord-301362-f3lp10lm	223	11	from	from	IN
cord-301362-f3lp10lm	223	12	others	other	NNS
cord-301362-f3lp10lm	223	13	+	+	SYM
cord-301362-f3lp10lm	223	14	sRNA	srna	NN
cord-301362-f3lp10lm	223	15	viruses	virus	NNS
cord-301362-f3lp10lm	223	16	,	,	,
cord-301362-f3lp10lm	223	17	without	without	IN
cord-301362-f3lp10lm	223	18	the	the	DT
cord-301362-f3lp10lm	223	19	replication	replication	NN
cord-301362-f3lp10lm	223	20	-	-	HYPH
cord-301362-f3lp10lm	223	21	competent	competent	JJ
cord-301362-f3lp10lm	223	22	viral	viral	JJ
cord-301362-f3lp10lm	223	23	genome	genome	NN
cord-301362-f3lp10lm	223	24	,	,	,
cord-301362-f3lp10lm	223	25	can	can	MD
cord-301362-f3lp10lm	223	26	initiate	initiate	VB
cord-301362-f3lp10lm	223	27	INF	INF	NNP
cord-301362-f3lp10lm	223	28	-	-	HYPH
cord-301362-f3lp10lm	223	29	β	β	NN
cord-301362-f3lp10lm	223	30	promoter	promoter	NN
cord-301362-f3lp10lm	223	31	;	;	:
cord-301362-f3lp10lm	223	32	the	the	DT
cord-301362-f3lp10lm	223	33	authors	author	NNS
cord-301362-f3lp10lm	223	34	approached	approach	VBD
cord-301362-f3lp10lm	223	35	their	-PRON-	PRP$
cord-301362-f3lp10lm	223	36	study	study	NN
cord-301362-f3lp10lm	223	37	uncoupling	uncouple	VBG
cord-301362-f3lp10lm	223	38	the	the	DT
cord-301362-f3lp10lm	223	39	SFV	SFV	NNP
cord-301362-f3lp10lm	223	40	replicase	replicase	NN
cord-301362-f3lp10lm	223	41	expression	expression	NN
cord-301362-f3lp10lm	223	42	from	from	IN
cord-301362-f3lp10lm	223	43	the	the	DT
cord-301362-f3lp10lm	223	44	viral	viral	JJ
cord-301362-f3lp10lm	223	45	RNA	RNA	NNP
cord-301362-f3lp10lm	223	46	expression	expression	NN
cord-301362-f3lp10lm	223	47	.	.	.
cord-301362-f3lp10lm	224	1	For	for	IN
cord-301362-f3lp10lm	224	2	achieving	achieve	VBG
cord-301362-f3lp10lm	224	3	this	this	DT
cord-301362-f3lp10lm	224	4	,	,	,
cord-301362-f3lp10lm	224	5	they	-PRON-	PRP
cord-301362-f3lp10lm	224	6	generated	generate	VBD
cord-301362-f3lp10lm	224	7	a	a	DT
cord-301362-f3lp10lm	224	8	plasmid	plasmid	NN
cord-301362-f3lp10lm	224	9	construction	construction	NN
cord-301362-f3lp10lm	224	10	bearing	bear	VBG
cord-301362-f3lp10lm	224	11	the	the	DT
cord-301362-f3lp10lm	224	12	coding	code	VBG
cord-301362-f3lp10lm	224	13	sequence	sequence	NN
cord-301362-f3lp10lm	224	14	of	of	IN
cord-301362-f3lp10lm	224	15	the	the	DT
cord-301362-f3lp10lm	224	16	RdRp	RdRp	NNP
cord-301362-f3lp10lm	224	17	from	from	IN
cord-301362-f3lp10lm	224	18	a	a	DT
cord-301362-f3lp10lm	224	19	pathogenic	pathogenic	JJ
cord-301362-f3lp10lm	224	20	SFV	sfv	NN
cord-301362-f3lp10lm	224	21	strain	strain	NN
cord-301362-f3lp10lm	224	22	,	,	,
cord-301362-f3lp10lm	224	23	SFV4	SFV4	NNP
cord-301362-f3lp10lm	224	24	pRep	pRep	NNP
cord-301362-f3lp10lm	224	25	.	.	.
cord-301362-f3lp10lm	225	1	As	as	IN
cord-301362-f3lp10lm	225	2	a	a	DT
cord-301362-f3lp10lm	225	3	control	control	NN
cord-301362-f3lp10lm	225	4	,	,	,
cord-301362-f3lp10lm	225	5	they	-PRON-	PRP
cord-301362-f3lp10lm	225	6	generated	generate	VBD
cord-301362-f3lp10lm	225	7	a	a	DT
cord-301362-f3lp10lm	225	8	plasmid	plasmid	NN
cord-301362-f3lp10lm	225	9	coding	code	VBG
cord-301362-f3lp10lm	225	10	an	an	DT
cord-301362-f3lp10lm	225	11	inactive	inactive	JJ
cord-301362-f3lp10lm	225	12	version	version	NN
cord-301362-f3lp10lm	225	13	harboring	harbor	VBG
cord-301362-f3lp10lm	225	14	two	two	CD
cord-301362-f3lp10lm	225	15	changes	change	NNS
cord-301362-f3lp10lm	225	16	in	in	IN
cord-301362-f3lp10lm	225	17	the	the	DT
cord-301362-f3lp10lm	225	18	RdRp	RdRp	NNP
cord-301362-f3lp10lm	225	19	specific	specific	JJ
cord-301362-f3lp10lm	225	20	catalytic	catalytic	JJ
cord-301362-f3lp10lm	225	21	domain	domain	NN
cord-301362-f3lp10lm	225	22	of	of	IN
cord-301362-f3lp10lm	225	23	the	the	DT
cord-301362-f3lp10lm	225	24	nsP4	nsP4	NNS
cord-301362-f3lp10lm	225	25	,	,	,
cord-301362-f3lp10lm	225	26	pRep	pRep	NNP
cord-301362-f3lp10lm	225	27	-	-	HYPH
cord-301362-f3lp10lm	225	28	GA	GA	NNP
cord-301362-f3lp10lm	225	29	(	(	-LRB-
cord-301362-f3lp10lm	225	30	Kamer	Kamer	NNP
cord-301362-f3lp10lm	225	31	and	and	CC
cord-301362-f3lp10lm	225	32	Argos	Argos	NNP
cord-301362-f3lp10lm	225	33	,	,	,
cord-301362-f3lp10lm	225	34	1984	1984	CD
cord-301362-f3lp10lm	225	35	)	)	-RRB-
cord-301362-f3lp10lm	225	36	.	.	.
cord-301362-f3lp10lm	226	1	They	-PRON-	PRP
cord-301362-f3lp10lm	226	2	observed	observe	VBD
cord-301362-f3lp10lm	226	3	that	that	IN
cord-301362-f3lp10lm	226	4	active	active	JJ
cord-301362-f3lp10lm	226	5	SFV	sfv	NN
cord-301362-f3lp10lm	226	6	replicase	replicase	NN
cord-301362-f3lp10lm	226	7	is	be	VBZ
cord-301362-f3lp10lm	226	8	able	able	JJ
cord-301362-f3lp10lm	226	9	of	of	IN
cord-301362-f3lp10lm	226	10	inducing	induce	VBG
cord-301362-f3lp10lm	226	11	INF	INF	NNP
cord-301362-f3lp10lm	226	12	-	-	HYPH
cord-301362-f3lp10lm	226	13	β	β	NN
cord-301362-f3lp10lm	226	14	without	without	IN
cord-301362-f3lp10lm	226	15	the	the	DT
cord-301362-f3lp10lm	226	16	replicationcompetent	replicationcompetent	NN
cord-301362-f3lp10lm	226	17	viral	viral	JJ
cord-301362-f3lp10lm	226	18	RNA	RNA	NNP
cord-301362-f3lp10lm	226	19	.	.	.
cord-301362-f3lp10lm	227	1	Employing	employ	VBG
cord-301362-f3lp10lm	227	2	interfering	interfere	VBG
cord-301362-f3lp10lm	227	3	experiments	experiment	NNS
cord-301362-f3lp10lm	227	4	they	-PRON-	PRP
cord-301362-f3lp10lm	227	5	demonstrated	demonstrate	VBD
cord-301362-f3lp10lm	227	6	that	that	IN
cord-301362-f3lp10lm	227	7	RIG	rig	NN
cord-301362-f3lp10lm	227	8	-	-	:
cord-301362-f3lp10lm	227	9	I	-PRON-	PRP
cord-301362-f3lp10lm	227	10	is	be	VBZ
cord-301362-f3lp10lm	227	11	the	the	DT
cord-301362-f3lp10lm	227	12	major	major	JJ
cord-301362-f3lp10lm	227	13	sensor	sensor	NN
cord-301362-f3lp10lm	227	14	mediating	mediate	VBG
cord-301362-f3lp10lm	227	15	INFβ	infβ	JJ
cord-301362-f3lp10lm	227	16	induction	induction	NN
cord-301362-f3lp10lm	227	17	with	with	IN
cord-301362-f3lp10lm	227	18	MDA-5	MDA-5	NNP
cord-301362-f3lp10lm	227	19	acting	act	VBG
cord-301362-f3lp10lm	227	20	as	as	IN
cord-301362-f3lp10lm	227	21	an	an	DT
cord-301362-f3lp10lm	227	22	additional	additional	JJ
cord-301362-f3lp10lm	227	23	sensor	sensor	NN
cord-301362-f3lp10lm	227	24	,	,	,
cord-301362-f3lp10lm	227	25	also	also	RB
cord-301362-f3lp10lm	227	26	contributing	contribute	VBG
cord-301362-f3lp10lm	227	27	to	to	IN
cord-301362-f3lp10lm	227	28	INF	INF	NNP
cord-301362-f3lp10lm	227	29	-	-	HYPH
cord-301362-f3lp10lm	227	30	β	β	NN
cord-301362-f3lp10lm	227	31	enhancement	enhancement	NN
cord-301362-f3lp10lm	227	32	.	.	.
cord-301362-f3lp10lm	228	1	Since	since	IN
cord-301362-f3lp10lm	228	2	RIG	rig	NN
cord-301362-f3lp10lm	228	3	-	-	:
cord-301362-f3lp10lm	228	4	I	-PRON-	PRP
cord-301362-f3lp10lm	228	5	was	be	VBD
cord-301362-f3lp10lm	228	6	involved	involve	VBN
cord-301362-f3lp10lm	228	7	,	,	,
cord-301362-f3lp10lm	228	8	they	-PRON-	PRP
cord-301362-f3lp10lm	228	9	suspected	suspect	VBD
cord-301362-f3lp10lm	228	10	that	that	DT
cord-301362-f3lp10lm	228	11	expression	expression	NN
cord-301362-f3lp10lm	228	12	of	of	IN
cord-301362-f3lp10lm	228	13	SFV	SFV	NNP
cord-301362-f3lp10lm	228	14	replicase	replicase	NN
cord-301362-f3lp10lm	228	15	was	be	VBD
cord-301362-f3lp10lm	228	16	responsible	responsible	JJ
cord-301362-f3lp10lm	228	17	for	for	IN
cord-301362-f3lp10lm	228	18	generating	generate	VBG
cord-301362-f3lp10lm	228	19	PAMPs	pamp	NNS
cord-301362-f3lp10lm	228	20	so	so	IN
cord-301362-f3lp10lm	228	21	they	-PRON-	PRP
cord-301362-f3lp10lm	228	22	characterized	characterize	VBD
cord-301362-f3lp10lm	228	23	these	these	DT
cord-301362-f3lp10lm	228	24	molecules	molecule	NNS
cord-301362-f3lp10lm	228	25	and	and	CC
cord-301362-f3lp10lm	228	26	observed	observe	VBD
cord-301362-f3lp10lm	228	27	the	the	DT
cord-301362-f3lp10lm	228	28	generation	generation	NN
cord-301362-f3lp10lm	228	29	of	of	IN
cord-301362-f3lp10lm	228	30	non	non	JJ
cord-301362-f3lp10lm	228	31	-	-	JJ
cord-301362-f3lp10lm	228	32	polyadenilated	polyadenilated	JJ
cord-301362-f3lp10lm	228	33	RNA	RNA	NNP
cord-301362-f3lp10lm	228	34	species	specie	NNS
cord-301362-f3lp10lm	228	35	,	,	,
cord-301362-f3lp10lm	228	36	larger	large	JJR
cord-301362-f3lp10lm	228	37	than	than	IN
cord-301362-f3lp10lm	228	38	200	200	CD
cord-301362-f3lp10lm	228	39	nucleotides	nucleotide	NNS
cord-301362-f3lp10lm	228	40	,	,	,
cord-301362-f3lp10lm	228	41	containing	contain	VBG
cord-301362-f3lp10lm	228	42	dsRNA	dsrna	NN
cord-301362-f3lp10lm	228	43	regions	region	NNS
cord-301362-f3lp10lm	228	44	and	and	CC
cord-301362-f3lp10lm	228	45	a	a	DT
cord-301362-f3lp10lm	228	46	terminal	terminal	JJ
cord-301362-f3lp10lm	228	47	5	5	CD
cord-301362-f3lp10lm	228	48	′	′	CD
cord-301362-f3lp10lm	228	49	-phosphate	-phosphate	CD
cord-301362-f3lp10lm	228	50	.	.	.
cord-301362-f3lp10lm	229	1	Moreover	moreover	RB
cord-301362-f3lp10lm	229	2	,	,	,
cord-301362-f3lp10lm	229	3	they	-PRON-	PRP
cord-301362-f3lp10lm	229	4	showed	show	VBD
cord-301362-f3lp10lm	229	5	that	that	IN
cord-301362-f3lp10lm	229	6	those	those	DT
cord-301362-f3lp10lm	229	7	dsRNA	dsrna	JJ
cord-301362-f3lp10lm	229	8	structures	structure	NNS
cord-301362-f3lp10lm	229	9	generated	generate	VBN
cord-301362-f3lp10lm	229	10	by	by	IN
cord-301362-f3lp10lm	229	11	SFV	SFV	NNP
cord-301362-f3lp10lm	229	12	replicase	replicase	NN
cord-301362-f3lp10lm	229	13	associated	associate	VBN
cord-301362-f3lp10lm	229	14	to	to	IN
cord-301362-f3lp10lm	229	15	endosomes	endosome	NNS
cord-301362-f3lp10lm	229	16	and	and	CC
cord-301362-f3lp10lm	229	17	lysosomes	lysosome	NNS
cord-301362-f3lp10lm	229	18	were	be	VBD
cord-301362-f3lp10lm	229	19	the	the	DT
cord-301362-f3lp10lm	229	20	strongest	strong	JJS
cord-301362-f3lp10lm	229	21	INF	inf	NN
cord-301362-f3lp10lm	229	22	-	-	HYPH
cord-301362-f3lp10lm	229	23	β	β	NN
cord-301362-f3lp10lm	229	24	inducers	inducer	NNS
cord-301362-f3lp10lm	229	25	from	from	IN
cord-301362-f3lp10lm	229	26	those	those	DT
cord-301362-f3lp10lm	229	27	present	present	JJ
cord-301362-f3lp10lm	229	28	in	in	IN
cord-301362-f3lp10lm	229	29	the	the	DT
cord-301362-f3lp10lm	229	30	cell	cell	NN
cord-301362-f3lp10lm	229	31	,	,	,
cord-301362-f3lp10lm	229	32	reinforcing	reinforce	VBG
cord-301362-f3lp10lm	229	33	the	the	DT
cord-301362-f3lp10lm	229	34	notion	notion	NN
cord-301362-f3lp10lm	229	35	that	that	IN
cord-301362-f3lp10lm	229	36	these	these	DT
cord-301362-f3lp10lm	229	37	organelles	organelle	NNS
cord-301362-f3lp10lm	229	38	serve	serve	VBP
cord-301362-f3lp10lm	229	39	as	as	IN
cord-301362-f3lp10lm	229	40	the	the	DT
cord-301362-f3lp10lm	229	41	sites	site	NNS
cord-301362-f3lp10lm	229	42	of	of	IN
cord-301362-f3lp10lm	229	43	SFV	SFV	NNP
cord-301362-f3lp10lm	229	44	replicase	replicase	NN
cord-301362-f3lp10lm	229	45	docking	docking	NN
cord-301362-f3lp10lm	229	46	and	and	CC
cord-301362-f3lp10lm	229	47	viral	viral	JJ
cord-301362-f3lp10lm	229	48	dsRNA	dsrna	NN
cord-301362-f3lp10lm	229	49	intermediates	intermediate	NNS
cord-301362-f3lp10lm	229	50	generation	generation	NN
cord-301362-f3lp10lm	229	51	.	.	.
cord-301362-f3lp10lm	230	1	Based	base	VBN
cord-301362-f3lp10lm	230	2	on	on	IN
cord-301362-f3lp10lm	230	3	these	these	DT
cord-301362-f3lp10lm	230	4	and	and	CC
cord-301362-f3lp10lm	230	5	other	other	JJ
cord-301362-f3lp10lm	230	6	results	result	NNS
cord-301362-f3lp10lm	230	7	obtained	obtain	VBN
cord-301362-f3lp10lm	230	8	through	through	IN
cord-301362-f3lp10lm	230	9	elegant	elegant	JJ
cord-301362-f3lp10lm	230	10	approaches	approach	NNS
cord-301362-f3lp10lm	230	11	,	,	,
cord-301362-f3lp10lm	230	12	the	the	DT
cord-301362-f3lp10lm	230	13	authors	author	NNS
cord-301362-f3lp10lm	230	14	proposed	propose	VBD
cord-301362-f3lp10lm	230	15	a	a	DT
cord-301362-f3lp10lm	230	16	novel	novel	JJ
cord-301362-f3lp10lm	230	17	mechanism	mechanism	NN
cord-301362-f3lp10lm	230	18	of	of	IN
cord-301362-f3lp10lm	230	19	PAMPs	PAMPs	NNP
cord-301362-f3lp10lm	230	20	generation	generation	NN
cord-301362-f3lp10lm	230	21	and	and	CC
cord-301362-f3lp10lm	230	22	INF	inf	NN
cord-301362-f3lp10lm	230	23	-	-	HYPH
cord-301362-f3lp10lm	230	24	β	β	NN
cord-301362-f3lp10lm	230	25	induction	induction	NN
cord-301362-f3lp10lm	230	26	by	by	IN
cord-301362-f3lp10lm	230	27	the	the	DT
cord-301362-f3lp10lm	230	28	viral	viral	JJ
cord-301362-f3lp10lm	230	29	replicase	replicase	NN
cord-301362-f3lp10lm	230	30	transcription	transcription	NN
cord-301362-f3lp10lm	230	31	of	of	IN
cord-301362-f3lp10lm	230	32	non	non	JJ
cord-301362-f3lp10lm	230	33	-	-	JJ
cord-301362-f3lp10lm	230	34	viral	viral	JJ
cord-301362-f3lp10lm	230	35	host	host	NN
cord-301362-f3lp10lm	230	36	-	-	HYPH
cord-301362-f3lp10lm	230	37	cell	cell	NN
cord-301362-f3lp10lm	230	38	RNA	RNA	NNP
cord-301362-f3lp10lm	230	39	templates	template	NNS
cord-301362-f3lp10lm	230	40	.	.	.
cord-301362-f3lp10lm	231	1	At	at	IN
cord-301362-f3lp10lm	231	2	the	the	DT
cord-301362-f3lp10lm	231	3	same	same	JJ
cord-301362-f3lp10lm	231	4	time	time	NN
cord-301362-f3lp10lm	231	5	,	,	,
cord-301362-f3lp10lm	231	6	the	the	DT
cord-301362-f3lp10lm	231	7	viral	viral	JJ
cord-301362-f3lp10lm	231	8	replicase	replicase	NN
cord-301362-f3lp10lm	231	9	molecules	molecule	NNS
cord-301362-f3lp10lm	231	10	would	would	MD
cord-301362-f3lp10lm	231	11	anchor	anchor	VB
cord-301362-f3lp10lm	231	12	to	to	IN
cord-301362-f3lp10lm	231	13	endosomes	endosomes	JJ
cord-301362-f3lp10lm	231	14	membranes	membrane	NNS
cord-301362-f3lp10lm	231	15	to	to	TO
cord-301362-f3lp10lm	231	16	build	build	VB
cord-301362-f3lp10lm	231	17	up	up	RP
cord-301362-f3lp10lm	231	18	membranous	membranous	JJ
cord-301362-f3lp10lm	231	19	spherules	spherule	NNS
cord-301362-f3lp10lm	231	20	where	where	WRB
cord-301362-f3lp10lm	231	21	viral	viral	JJ
cord-301362-f3lp10lm	231	22	dsRNA	dsrna	NN
cord-301362-f3lp10lm	231	23	or	or	CC
cord-301362-f3lp10lm	231	24	5-ppp	5-ppp	NNP
cord-301362-f3lp10lm	231	25	RNA	RNA	NNP
cord-301362-f3lp10lm	231	26	intermediates	intermediate	NNS
cord-301362-f3lp10lm	231	27	keep	keep	VBP
cord-301362-f3lp10lm	231	28	inaccessible	inaccessible	JJ
cord-301362-f3lp10lm	231	29	to	to	TO
cord-301362-f3lp10lm	231	30	host	host	VB
cord-301362-f3lp10lm	231	31	sensors	sensor	NNS
cord-301362-f3lp10lm	231	32	any	any	RB
cord-301362-f3lp10lm	231	33	longer	long	RBR
cord-301362-f3lp10lm	231	34	,	,	,
cord-301362-f3lp10lm	231	35	as	as	IN
cord-301362-f3lp10lm	231	36	suggested	suggest	VBN
cord-301362-f3lp10lm	231	37	by	by	IN
cord-301362-f3lp10lm	231	38	Nikonov	Nikonov	NNP
cord-301362-f3lp10lm	231	39	and	and	CC
cord-301362-f3lp10lm	231	40	Nikonov	Nikonov	NNP
cord-301362-f3lp10lm	231	41	et	et	NNP
cord-301362-f3lp10lm	231	42	al	al	NNP
cord-301362-f3lp10lm	231	43	.	.	.
cord-301362-f3lp10lm	232	1	(	(	-LRB-
cord-301362-f3lp10lm	232	2	2013	2013	CD
cord-301362-f3lp10lm	232	3	)	)	-RRB-
cord-301362-f3lp10lm	232	4	,	,	.
cord-301362-f3lp10lm	233	1	shown	show	VBN
cord-301362-f3lp10lm	233	2	in	in	IN
cord-301362-f3lp10lm	233	3	Figure	Figure	NNP
cord-301362-f3lp10lm	233	4	1	1	CD
cord-301362-f3lp10lm	233	5	.	.	.
cord-301362-f3lp10lm	234	1	Accordingly	accordingly	RB
cord-301362-f3lp10lm	234	2	,	,	,
cord-301362-f3lp10lm	234	3	employing	employ	VBG
cord-301362-f3lp10lm	234	4	adenoviral	adenoviral	JJ
cord-301362-f3lp10lm	234	5	vectors	vector	NNS
cord-301362-f3lp10lm	234	6	as	as	IN
cord-301362-f3lp10lm	234	7	delivery	delivery	NN
cord-301362-f3lp10lm	234	8	method	method	NN
cord-301362-f3lp10lm	234	9	into	into	IN
cord-301362-f3lp10lm	234	10	murine	murine	JJ
cord-301362-f3lp10lm	234	11	and	and	CC
cord-301362-f3lp10lm	234	12	human	human	JJ
cord-301362-f3lp10lm	234	13	hepatocytes	hepatocyte	NNS
cord-301362-f3lp10lm	234	14	,	,	,
cord-301362-f3lp10lm	234	15	Yu	Yu	NNP
cord-301362-f3lp10lm	234	16	and	and	CC
cord-301362-f3lp10lm	234	17	colleagues	colleague	NNS
cord-301362-f3lp10lm	234	18	demonstrated	demonstrate	VBD
cord-301362-f3lp10lm	234	19	that	that	IN
cord-301362-f3lp10lm	234	20	the	the	DT
cord-301362-f3lp10lm	234	21	Hepatitis	Hepatitis	NNP
cord-301362-f3lp10lm	234	22	C	C	NNP
cord-301362-f3lp10lm	234	23	Virus	Virus	NNP
cord-301362-f3lp10lm	234	24	(	(	-LRB-
cord-301362-f3lp10lm	234	25	HCV	HCV	NNP
cord-301362-f3lp10lm	234	26	)	)	-RRB-
cord-301362-f3lp10lm	234	27	RdRp	RdRp	NNP
cord-301362-f3lp10lm	235	1	NS5B	NS5B	NNP
cord-301362-f3lp10lm	235	2	was	be	VBD
cord-301362-f3lp10lm	235	3	capable	capable	JJ
cord-301362-f3lp10lm	235	4	of	of	IN
cord-301362-f3lp10lm	235	5	inducing	induce	VBG
cord-301362-f3lp10lm	235	6	the	the	DT
cord-301362-f3lp10lm	235	7	innate	innate	JJ
cord-301362-f3lp10lm	235	8	immune	immune	JJ
cord-301362-f3lp10lm	235	9	response	response	NN
cord-301362-f3lp10lm	235	10	in	in	IN
cord-301362-f3lp10lm	235	11	the	the	DT
cord-301362-f3lp10lm	235	12	absence	absence	NN
cord-301362-f3lp10lm	235	13	of	of	IN
cord-301362-f3lp10lm	235	14	other	other	JJ
cord-301362-f3lp10lm	235	15	HCV	HCV	NNP
cord-301362-f3lp10lm	235	16	RNA	RNA	NNP
cord-301362-f3lp10lm	235	17	replication	replication	NN
cord-301362-f3lp10lm	235	18	components	component	NNS
cord-301362-f3lp10lm	235	19	and/or	and/or	CC
cord-301362-f3lp10lm	235	20	other	other	JJ
cord-301362-f3lp10lm	235	21	nonstructural	nonstructural	JJ
cord-301362-f3lp10lm	235	22	proteins	protein	NNS
cord-301362-f3lp10lm	235	23	.	.	.
cord-301362-f3lp10lm	236	1	They	-PRON-	PRP
cord-301362-f3lp10lm	236	2	further	further	RB
cord-301362-f3lp10lm	236	3	showed	show	VBD
cord-301362-f3lp10lm	236	4	that	that	IN
cord-301362-f3lp10lm	236	5	this	this	DT
cord-301362-f3lp10lm	236	6	induction	induction	NN
cord-301362-f3lp10lm	236	7	was	be	VBD
cord-301362-f3lp10lm	236	8	dependent	dependent	JJ
cord-301362-f3lp10lm	236	9	upon	upon	IN
cord-301362-f3lp10lm	236	10	the	the	DT
cord-301362-f3lp10lm	236	11	NS5B	ns5b	CD
cord-301362-f3lp10lm	236	12	enzymatic	enzymatic	JJ
cord-301362-f3lp10lm	236	13	activity	activity	NN
cord-301362-f3lp10lm	236	14	and	and	CC
cord-301362-f3lp10lm	236	15	on	on	IN
cord-301362-f3lp10lm	236	16	the	the	DT
cord-301362-f3lp10lm	236	17	adaptor	adaptor	NN
cord-301362-f3lp10lm	236	18	protein	protein	NN
cord-301362-f3lp10lm	236	19	MAVS	MAVS	NNPS
cord-301362-f3lp10lm	236	20	that	that	IN
cord-301362-f3lp10lm	236	21	functions	function	VBZ
cord-301362-f3lp10lm	236	22	downstream	downstream	RB
cord-301362-f3lp10lm	236	23	of	of	IN
cord-301362-f3lp10lm	236	24	RIG	rig	NN
cord-301362-f3lp10lm	236	25	-	-	:
cord-301362-f3lp10lm	236	26	I	I	NNP
cord-301362-f3lp10lm	236	27	and	and	CC
cord-301362-f3lp10lm	236	28	MDA5	MDA5	NNP
cord-301362-f3lp10lm	237	1	(	(	-LRB-
cord-301362-f3lp10lm	237	2	Yu	Yu	NNP
cord-301362-f3lp10lm	237	3	et	et	FW
cord-301362-f3lp10lm	237	4	al	al	NNP
cord-301362-f3lp10lm	237	5	.	.	NNP
cord-301362-f3lp10lm	237	6	,	,	,
cord-301362-f3lp10lm	237	7	2012	2012	CD
cord-301362-f3lp10lm	237	8	)	)	-RRB-
cord-301362-f3lp10lm	237	9	.	.	.
cord-301362-f3lp10lm	238	1	Supporting	support	VBG
cord-301362-f3lp10lm	238	2	this	this	DT
cord-301362-f3lp10lm	238	3	novel	novel	JJ
cord-301362-f3lp10lm	238	4	mechanism	mechanism	NN
cord-301362-f3lp10lm	238	5	of	of	IN
cord-301362-f3lp10lm	238	6	innate	innate	JJ
cord-301362-f3lp10lm	238	7	immune	immune	JJ
cord-301362-f3lp10lm	238	8	antiviral	antiviral	JJ
cord-301362-f3lp10lm	238	9	response	response	NN
cord-301362-f3lp10lm	238	10	activation	activation	NN
cord-301362-f3lp10lm	238	11	,	,	,
cord-301362-f3lp10lm	238	12	Painter	painter	NN
cord-301362-f3lp10lm	238	13	and	and	CC
cord-301362-f3lp10lm	238	14	colleagues	colleague	NNS
cord-301362-f3lp10lm	238	15	observed	observe	VBD
cord-301362-f3lp10lm	238	16	that	that	IN
cord-301362-f3lp10lm	238	17	the	the	DT
cord-301362-f3lp10lm	238	18	ectopic	ectopic	JJ
cord-301362-f3lp10lm	238	19	expression	expression	NN
cord-301362-f3lp10lm	238	20	of	of	IN
cord-301362-f3lp10lm	238	21	RdRp	RdRp	NNP
cord-301362-f3lp10lm	238	22	from	from	IN
cord-301362-f3lp10lm	238	23	Theiler	Theiler	NNP
cord-301362-f3lp10lm	238	24	's	's	POS
cord-301362-f3lp10lm	238	25	murine	murine	JJ
cord-301362-f3lp10lm	238	26	encephalomyelitis	encephalomyelitis	NN
cord-301362-f3lp10lm	238	27	virus	virus	NN
cord-301362-f3lp10lm	238	28	(	(	-LRB-
cord-301362-f3lp10lm	238	29	TMEV	TMEV	NNP
cord-301362-f3lp10lm	238	30	,	,	,
cord-301362-f3lp10lm	238	31	member	member	NN
cord-301362-f3lp10lm	238	32	of	of	IN
cord-301362-f3lp10lm	238	33	the	the	DT
cord-301362-f3lp10lm	238	34	Picornaviridae	Picornaviridae	NNP
cord-301362-f3lp10lm	238	35	family	family	NN
cord-301362-f3lp10lm	238	36	)	)	-RRB-
cord-301362-f3lp10lm	238	37	,	,	,
cord-301362-f3lp10lm	238	38	in	in	IN
cord-301362-f3lp10lm	238	39	the	the	DT
cord-301362-f3lp10lm	238	40	complete	complete	JJ
cord-301362-f3lp10lm	238	41	absence	absence	NN
cord-301362-f3lp10lm	238	42	of	of	IN
cord-301362-f3lp10lm	238	43	other	other	JJ
cord-301362-f3lp10lm	238	44	viral	viral	JJ
cord-301362-f3lp10lm	238	45	structures	structure	NNS
cord-301362-f3lp10lm	238	46	,	,	,
cord-301362-f3lp10lm	238	47	is	be	VBZ
cord-301362-f3lp10lm	238	48	able	able	JJ
cord-301362-f3lp10lm	238	49	to	to	TO
cord-301362-f3lp10lm	238	50	induce	induce	VB
cord-301362-f3lp10lm	238	51	ISG	ISG	NNP
cord-301362-f3lp10lm	238	52	activation	activation	NN
cord-301362-f3lp10lm	238	53	in	in	IN
cord-301362-f3lp10lm	238	54	an	an	DT
cord-301362-f3lp10lm	238	55	MDA5-dependent	MDA5-dependent	NNP
cord-301362-f3lp10lm	238	56	fashion	fashion	NN
cord-301362-f3lp10lm	238	57	.	.	.
cord-301362-f3lp10lm	239	1	The	the	DT
cord-301362-f3lp10lm	239	2	authors	author	NNS
cord-301362-f3lp10lm	239	3	showed	show	VBD
cord-301362-f3lp10lm	239	4	the	the	DT
cord-301362-f3lp10lm	239	5	presence	presence	NN
cord-301362-f3lp10lm	239	6	of	of	IN
cord-301362-f3lp10lm	239	7	endogenous	endogenous	JJ
cord-301362-f3lp10lm	239	8	dsRNA	dsrna	NN
cord-301362-f3lp10lm	239	9	molecules	molecule	NNS
cord-301362-f3lp10lm	239	10	in	in	IN
cord-301362-f3lp10lm	239	11	un	un	NNP
cord-301362-f3lp10lm	239	12	-	-	HYPH
cord-301362-f3lp10lm	239	13	infected	infect	VBN
cord-301362-f3lp10lm	239	14	tissues	tissue	NNS
cord-301362-f3lp10lm	239	15	of	of	IN
cord-301362-f3lp10lm	239	16	RdRp	RdRp	NNP
cord-301362-f3lp10lm	239	17	transgenic	transgenic	JJ
cord-301362-f3lp10lm	239	18	mice	mouse	NNS
cord-301362-f3lp10lm	239	19	,	,	,
cord-301362-f3lp10lm	239	20	which	which	WDT
cord-301362-f3lp10lm	239	21	sustained	sustain	VBD
cord-301362-f3lp10lm	239	22	the	the	DT
cord-301362-f3lp10lm	239	23	MDA5-activation	mda5-activation	NN
cord-301362-f3lp10lm	239	24	.	.	.
cord-301362-f3lp10lm	240	1	At	at	IN
cord-301362-f3lp10lm	240	2	this	this	DT
cord-301362-f3lp10lm	240	3	point	point	NN
cord-301362-f3lp10lm	240	4	,	,	,
cord-301362-f3lp10lm	240	5	the	the	DT
cord-301362-f3lp10lm	240	6	authors	author	NNS
cord-301362-f3lp10lm	240	7	did	do	VBD
cord-301362-f3lp10lm	240	8	not	not	RB
cord-301362-f3lp10lm	240	9	observe	observe	VB
cord-301362-f3lp10lm	240	10	a	a	DT
cord-301362-f3lp10lm	240	11	role	role	NN
cord-301362-f3lp10lm	240	12	of	of	IN
cord-301362-f3lp10lm	240	13	RIG	rig	NN
cord-301362-f3lp10lm	240	14	-	-	:
cord-301362-f3lp10lm	240	15	I	-PRON-	PRP
cord-301362-f3lp10lm	240	16	in	in	IN
cord-301362-f3lp10lm	240	17	this	this	DT
cord-301362-f3lp10lm	240	18	process	process	NN
cord-301362-f3lp10lm	240	19	,	,	,
cord-301362-f3lp10lm	240	20	but	but	CC
cord-301362-f3lp10lm	240	21	neither	neither	DT
cord-301362-f3lp10lm	240	22	rule	rule	VB
cord-301362-f3lp10lm	240	23	out	out	RP
cord-301362-f3lp10lm	240	24	this	this	DT
cord-301362-f3lp10lm	240	25	possibility	possibility	NN
cord-301362-f3lp10lm	240	26	(	(	-LRB-
cord-301362-f3lp10lm	240	27	Painter	painter	NN
cord-301362-f3lp10lm	240	28	et	et	NNP
cord-301362-f3lp10lm	240	29	al	al	NNP
cord-301362-f3lp10lm	240	30	.	.	NNP
cord-301362-f3lp10lm	240	31	,	,	,
cord-301362-f3lp10lm	240	32	2015	2015	CD
cord-301362-f3lp10lm	240	33	)	)	-RRB-
cord-301362-f3lp10lm	240	34	.	.	.
cord-301362-f3lp10lm	241	1	Thus	thus	RB
cord-301362-f3lp10lm	241	2	,	,	,
cord-301362-f3lp10lm	241	3	despite	despite	IN
cord-301362-f3lp10lm	241	4	the	the	DT
cord-301362-f3lp10lm	241	5	few	few	JJ
cord-301362-f3lp10lm	241	6	+	+	SYM
cord-301362-f3lp10lm	241	7	sRNA	srna	NN
cord-301362-f3lp10lm	241	8	viruses	virus	NNS
cord-301362-f3lp10lm	241	9	for	for	IN
cord-301362-f3lp10lm	241	10	which	which	WDT
cord-301362-f3lp10lm	241	11	the	the	DT
cord-301362-f3lp10lm	241	12	induction	induction	NN
cord-301362-f3lp10lm	241	13	of	of	IN
cord-301362-f3lp10lm	241	14	the	the	DT
cord-301362-f3lp10lm	241	15	innate	innate	JJ
cord-301362-f3lp10lm	241	16	immune	immune	JJ
cord-301362-f3lp10lm	241	17	response	response	NN
cord-301362-f3lp10lm	241	18	has	have	VBZ
cord-301362-f3lp10lm	241	19	been	be	VBN
cord-301362-f3lp10lm	241	20	observed	observe	VBN
cord-301362-f3lp10lm	241	21	to	to	TO
cord-301362-f3lp10lm	241	22	be	be	VB
cord-301362-f3lp10lm	241	23	thanks	thank	NNS
cord-301362-f3lp10lm	241	24	to	to	IN
cord-301362-f3lp10lm	241	25	RdRp	RdRp	NNP
cord-301362-f3lp10lm	241	26	activity	activity	NN
cord-301362-f3lp10lm	241	27	,	,	,
cord-301362-f3lp10lm	241	28	it	-PRON-	PRP
cord-301362-f3lp10lm	241	29	seems	seem	VBZ
cord-301362-f3lp10lm	241	30	likely	likely	JJ
cord-301362-f3lp10lm	241	31	that	that	IN
cord-301362-f3lp10lm	241	32	it	-PRON-	PRP
cord-301362-f3lp10lm	241	33	may	may	MD
cord-301362-f3lp10lm	241	34	be	be	VB
cord-301362-f3lp10lm	241	35	a	a	DT
cord-301362-f3lp10lm	241	36	universal	universal	JJ
cord-301362-f3lp10lm	241	37	mechanism	mechanism	NN
cord-301362-f3lp10lm	241	38	employed	employ	VBN
cord-301362-f3lp10lm	241	39	by	by	IN
cord-301362-f3lp10lm	241	40	the	the	DT
cord-301362-f3lp10lm	241	41	host	host	NN
cord-301362-f3lp10lm	241	42	cell	cell	NN
cord-301362-f3lp10lm	241	43	to	to	TO
cord-301362-f3lp10lm	241	44	withstand	withstand	VB
cord-301362-f3lp10lm	241	45	the	the	DT
cord-301362-f3lp10lm	241	46	viral	viral	JJ
cord-301362-f3lp10lm	241	47	conquest	conquest	NN
cord-301362-f3lp10lm	241	48	.	.	.
cord-301362-f3lp10lm	242	1	In	in	IN
cord-301362-f3lp10lm	242	2	this	this	DT
cord-301362-f3lp10lm	242	3	context	context	NN
cord-301362-f3lp10lm	242	4	,	,	,
cord-301362-f3lp10lm	242	5	since	since	IN
cord-301362-f3lp10lm	242	6	+	+	SYM
cord-301362-f3lp10lm	242	7	sRNA	srna	NN
cord-301362-f3lp10lm	242	8	viruses	virus	NNS
cord-301362-f3lp10lm	242	9	conceal	conceal	VBP
cord-301362-f3lp10lm	242	10	the	the	DT
cord-301362-f3lp10lm	242	11	entire	entire	JJ
cord-301362-f3lp10lm	242	12	replication	replication	NN
cord-301362-f3lp10lm	242	13	machinery	machinery	NN
cord-301362-f3lp10lm	242	14	in	in	IN
cord-301362-f3lp10lm	242	15	membrane	membrane	NN
cord-301362-f3lp10lm	242	16	-	-	HYPH
cord-301362-f3lp10lm	242	17	bound	bind	VBN
cord-301362-f3lp10lm	242	18	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	242	19	compartments	compartment	NNS
cord-301362-f3lp10lm	242	20	achieved	achieve	VBN
cord-301362-f3lp10lm	242	21	by	by	IN
cord-301362-f3lp10lm	242	22	extensive	extensive	JJ
cord-301362-f3lp10lm	242	23	re	re	NN
cord-301362-f3lp10lm	242	24	-	-	NN
cord-301362-f3lp10lm	242	25	organization	organization	NN
cord-301362-f3lp10lm	242	26	of	of	IN
cord-301362-f3lp10lm	242	27	host	host	NN
cord-301362-f3lp10lm	242	28	organelle	organelle	NN
cord-301362-f3lp10lm	242	29	membranes	membrane	NNS
cord-301362-f3lp10lm	242	30	,	,	,
cord-301362-f3lp10lm	242	31	it	-PRON-	PRP
cord-301362-f3lp10lm	242	32	seems	seem	VBZ
cord-301362-f3lp10lm	242	33	to	to	TO
cord-301362-f3lp10lm	242	34	be	be	VB
cord-301362-f3lp10lm	242	35	a	a	DT
cord-301362-f3lp10lm	242	36	matter	matter	NN
cord-301362-f3lp10lm	242	37	of	of	IN
cord-301362-f3lp10lm	242	38	time	time	NN
cord-301362-f3lp10lm	242	39	lapsed	lapse	VBN
cord-301362-f3lp10lm	242	40	between	between	IN
cord-301362-f3lp10lm	242	41	virus	virus	NN
cord-301362-f3lp10lm	242	42	uncoating	uncoate	VBG
cord-301362-f3lp10lm	242	43	with	with	IN
cord-301362-f3lp10lm	242	44	RdRp	RdRp	NNP
cord-301362-f3lp10lm	242	45	emergence	emergence	NN
cord-301362-f3lp10lm	242	46	into	into	IN
cord-301362-f3lp10lm	242	47	the	the	DT
cord-301362-f3lp10lm	242	48	host	host	NN
cord-301362-f3lp10lm	242	49	's	's	POS
cord-301362-f3lp10lm	242	50	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	242	51	and	and	CC
cord-301362-f3lp10lm	242	52	the	the	DT
cord-301362-f3lp10lm	242	53	hideout	hideout	NN
cord-301362-f3lp10lm	242	54	of	of	IN
cord-301362-f3lp10lm	242	55	the	the	DT
cord-301362-f3lp10lm	242	56	replication	replication	NN
cord-301362-f3lp10lm	242	57	machinery	machinery	NN
cord-301362-f3lp10lm	242	58	.	.	.
cord-301362-f3lp10lm	243	1	Finally	finally	RB
cord-301362-f3lp10lm	243	2	,	,	,
cord-301362-f3lp10lm	243	3	and	and	CC
cord-301362-f3lp10lm	243	4	as	as	IN
cord-301362-f3lp10lm	243	5	a	a	DT
cord-301362-f3lp10lm	243	6	consequence	consequence	NN
cord-301362-f3lp10lm	243	7	,	,	,
cord-301362-f3lp10lm	243	8	illustrating	illustrate	VBG
cord-301362-f3lp10lm	243	9	the	the	DT
cord-301362-f3lp10lm	243	10	virus	virus	NN
cord-301362-f3lp10lm	243	11	-	-	HYPH
cord-301362-f3lp10lm	243	12	host	host	NN
cord-301362-f3lp10lm	243	13	cell	cell	NN
cord-301362-f3lp10lm	243	14	co	co	NN
cord-301362-f3lp10lm	243	15	-	-	JJ
cord-301362-f3lp10lm	243	16	evolution	evolution	JJ
cord-301362-f3lp10lm	243	17	process	process	NN
cord-301362-f3lp10lm	243	18	once	once	RB
cord-301362-f3lp10lm	243	19	more	more	RBR
cord-301362-f3lp10lm	243	20	,	,	,
cord-301362-f3lp10lm	243	21	virus	virus	NN
cord-301362-f3lp10lm	243	22	have	have	VBP
cord-301362-f3lp10lm	243	23	evolved	evolve	VBN
cord-301362-f3lp10lm	243	24	with	with	IN
cord-301362-f3lp10lm	243	25	weapons	weapon	NNS
cord-301362-f3lp10lm	243	26	to	to	TO
cord-301362-f3lp10lm	243	27	be	be	VB
cord-301362-f3lp10lm	243	28	protected	protect	VBN
cord-301362-f3lp10lm	243	29	from	from	IN
cord-301362-f3lp10lm	243	30	innate	innate	JJ
cord-301362-f3lp10lm	243	31	immune	immune	JJ
cord-301362-f3lp10lm	243	32	response	response	NN
cord-301362-f3lp10lm	243	33	recognition	recognition	NN
cord-301362-f3lp10lm	243	34	irrespective	irrespective	RB
cord-301362-f3lp10lm	243	35	of	of	IN
cord-301362-f3lp10lm	243	36	the	the	DT
cord-301362-f3lp10lm	243	37	origin	origin	NN
cord-301362-f3lp10lm	243	38	of	of	IN
cord-301362-f3lp10lm	243	39	PAMPs	pamp	NNS
cord-301362-f3lp10lm	243	40	generated	generate	VBN
cord-301362-f3lp10lm	243	41	during	during	IN
cord-301362-f3lp10lm	243	42	the	the	DT
cord-301362-f3lp10lm	243	43	course	course	NN
cord-301362-f3lp10lm	243	44	of	of	IN
cord-301362-f3lp10lm	243	45	infection	infection	NN
cord-301362-f3lp10lm	243	46	.	.	.
cord-301362-f3lp10lm	244	1	For	for	IN
cord-301362-f3lp10lm	244	2	many	many	JJ
cord-301362-f3lp10lm	244	3	+	+	CC
cord-301362-f3lp10lm	244	4	sRNA	srna	NN
cord-301362-f3lp10lm	244	5	viruses	virus	NNS
cord-301362-f3lp10lm	244	6	,	,	,
cord-301362-f3lp10lm	244	7	mentioned	mention	VBN
cord-301362-f3lp10lm	244	8	throughout	throughout	IN
cord-301362-f3lp10lm	244	9	this	this	DT
cord-301362-f3lp10lm	244	10	review	review	NN
cord-301362-f3lp10lm	244	11	,	,	,
cord-301362-f3lp10lm	244	12	RNA	RNA	NNP
cord-301362-f3lp10lm	244	13	replication	replication	NN
cord-301362-f3lp10lm	244	14	occurs	occur	VBZ
cord-301362-f3lp10lm	244	15	in	in	IN
cord-301362-f3lp10lm	244	16	association	association	NN
cord-301362-f3lp10lm	244	17	with	with	IN
cord-301362-f3lp10lm	244	18	50	50	CD
cord-301362-f3lp10lm	244	19	-	-	SYM
cord-301362-f3lp10lm	244	20	70	70	CD
cord-301362-f3lp10lm	244	21	nm	nm	NN
cord-301362-f3lp10lm	244	22	diameter	diameter	NN
cord-301362-f3lp10lm	244	23	membranous	membranous	JJ
cord-301362-f3lp10lm	244	24	vesicles	vesicle	NNS
cord-301362-f3lp10lm	244	25	or	or	CC
cord-301362-f3lp10lm	244	26	spherules	spherule	NNS
cord-301362-f3lp10lm	244	27	that	that	WDT
cord-301362-f3lp10lm	244	28	form	form	VBP
cord-301362-f3lp10lm	244	29	in	in	IN
cord-301362-f3lp10lm	244	30	the	the	DT
cord-301362-f3lp10lm	244	31	lumen	lumen	NN
cord-301362-f3lp10lm	244	32	of	of	IN
cord-301362-f3lp10lm	244	33	specific	specific	JJ
cord-301362-f3lp10lm	244	34	cellular	cellular	JJ
cord-301362-f3lp10lm	244	35	organelles	organelle	NNS
cord-301362-f3lp10lm	244	36	,	,	,
cord-301362-f3lp10lm	244	37	or	or	CC
cord-301362-f3lp10lm	244	38	in	in	IN
cord-301362-f3lp10lm	244	39	double	double	JJ
cord-301362-f3lp10lm	244	40	membrane	membrane	NN
cord-301362-f3lp10lm	244	41	vesicles	vesicle	NNS
cord-301362-f3lp10lm	244	42	,	,	,
cord-301362-f3lp10lm	244	43	reminiscent	reminiscent	JJ
cord-301362-f3lp10lm	244	44	to	to	IN
cord-301362-f3lp10lm	244	45	that	that	DT
cord-301362-f3lp10lm	244	46	of	of	IN
cord-301362-f3lp10lm	244	47	the	the	DT
cord-301362-f3lp10lm	244	48	autophagic	autophagic	NNP
cord-301362-f3lp10lm	244	49	pathway	pathway	NN
cord-301362-f3lp10lm	244	50	.	.	.
cord-301362-f3lp10lm	245	1	Although	although	IN
cord-301362-f3lp10lm	245	2	important	important	JJ
cord-301362-f3lp10lm	245	3	discoveries	discovery	NNS
cord-301362-f3lp10lm	245	4	on	on	IN
cord-301362-f3lp10lm	245	5	the	the	DT
cord-301362-f3lp10lm	245	6	3-D	3-d	JJ
cord-301362-f3lp10lm	245	7	architecture	architecture	NN
cord-301362-f3lp10lm	245	8	of	of	IN
cord-301362-f3lp10lm	245	9	+	+	SYM
cord-301362-f3lp10lm	245	10	sRNA	srna	NN
cord-301362-f3lp10lm	245	11	virus	virus	NN
cord-301362-f3lp10lm	245	12	replication	replication	NN
cord-301362-f3lp10lm	245	13	factories	factory	NNS
cord-301362-f3lp10lm	245	14	have	have	VBP
cord-301362-f3lp10lm	245	15	been	be	VBN
cord-301362-f3lp10lm	245	16	made	make	VBN
cord-301362-f3lp10lm	245	17	,	,	,
cord-301362-f3lp10lm	245	18	current	current	JJ
cord-301362-f3lp10lm	245	19	knowledge	knowledge	NN
cord-301362-f3lp10lm	245	20	is	be	VBZ
cord-301362-f3lp10lm	245	21	largely	largely	RB
cord-301362-f3lp10lm	245	22	descriptive	descriptive	JJ
cord-301362-f3lp10lm	245	23	and	and	CC
cord-301362-f3lp10lm	245	24	important	important	JJ
cord-301362-f3lp10lm	245	25	information	information	NN
cord-301362-f3lp10lm	245	26	about	about	IN
cord-301362-f3lp10lm	245	27	mechanisms	mechanism	NNS
cord-301362-f3lp10lm	245	28	is	be	VBZ
cord-301362-f3lp10lm	245	29	FIGURE	FIGURE	NNP
cord-301362-f3lp10lm	245	30	1	1	CD
cord-301362-f3lp10lm	245	31	|	|	NNP
cord-301362-f3lp10lm	245	32	Proposed	propose	VBN
cord-301362-f3lp10lm	245	33	model	model	NN
cord-301362-f3lp10lm	245	34	of	of	IN
cord-301362-f3lp10lm	245	35	host	host	NN
cord-301362-f3lp10lm	245	36	-	-	HYPH
cord-301362-f3lp10lm	245	37	cell	cell	NN
cord-301362-f3lp10lm	245	38	mRNA	mrna	NN
cord-301362-f3lp10lm	245	39	replication	replication	NN
cord-301362-f3lp10lm	245	40	by	by	IN
cord-301362-f3lp10lm	245	41	+	+	SYM
cord-301362-f3lp10lm	245	42	sRNA	srna	NN
cord-301362-f3lp10lm	245	43	viruses	virus	NNS
cord-301362-f3lp10lm	245	44	'	'	POS
cord-301362-f3lp10lm	245	45	replicases	replicase	NNS
cord-301362-f3lp10lm	245	46	.	.	.
cord-301362-f3lp10lm	246	1	Inspired	inspire	VBN
cord-301362-f3lp10lm	246	2	by	by	IN
cord-301362-f3lp10lm	246	3	the	the	DT
cord-301362-f3lp10lm	246	4	"	"	``
cord-301362-f3lp10lm	246	5	Model	Model	NNP
cord-301362-f3lp10lm	246	6	of	of	IN
cord-301362-f3lp10lm	246	7	mutant	mutant	JJ
cord-301362-f3lp10lm	246	8	Semiliki	Semiliki	NNP
cord-301362-f3lp10lm	246	9	Forest	Forest	NNP
cord-301362-f3lp10lm	246	10	Virus	Virus	NNP
cord-301362-f3lp10lm	246	11	replication	replication	NN
cord-301362-f3lp10lm	246	12	restriction	restriction	NN
cord-301362-f3lp10lm	246	13	in	in	IN
cord-301362-f3lp10lm	246	14	fibroblasts	fibroblast	NNS
cord-301362-f3lp10lm	246	15	,	,	,
cord-301362-f3lp10lm	246	16	"	"	''
cord-301362-f3lp10lm	246	17	proposed	propose	VBN
cord-301362-f3lp10lm	246	18	by	by	IN
cord-301362-f3lp10lm	246	19	Nikonov	Nikonov	NNP
cord-301362-f3lp10lm	246	20	et	et	NNP
cord-301362-f3lp10lm	246	21	al	al	NNP
cord-301362-f3lp10lm	246	22	.	.	.
cord-301362-f3lp10lm	247	1	(	(	-LRB-
cord-301362-f3lp10lm	247	2	2013	2013	CD
cord-301362-f3lp10lm	247	3	)	)	-RRB-
cord-301362-f3lp10lm	247	4	.	.	.
cord-301362-f3lp10lm	248	1	After	after	IN
cord-301362-f3lp10lm	248	2	viral	viral	JJ
cord-301362-f3lp10lm	248	3	internalization	internalization	NN
cord-301362-f3lp10lm	248	4	and	and	CC
cord-301362-f3lp10lm	248	5	uncoating	uncoating	NN
cord-301362-f3lp10lm	248	6	,	,	,
cord-301362-f3lp10lm	248	7	the	the	DT
cord-301362-f3lp10lm	248	8	genomic	genomic	JJ
cord-301362-f3lp10lm	248	9	RNA	RNA	NNP
cord-301362-f3lp10lm	248	10	serves	serve	VBZ
cord-301362-f3lp10lm	248	11	as	as	IN
cord-301362-f3lp10lm	248	12	mRNA	mRNA	NNP
cord-301362-f3lp10lm	248	13	recognized	recognize	VBN
cord-301362-f3lp10lm	248	14	by	by	IN
cord-301362-f3lp10lm	248	15	the	the	DT
cord-301362-f3lp10lm	248	16	host	host	NN
cord-301362-f3lp10lm	248	17	cell	cell	NN
cord-301362-f3lp10lm	248	18	machinery	machinery	NN
cord-301362-f3lp10lm	248	19	to	to	TO
cord-301362-f3lp10lm	248	20	translate	translate	VB
cord-301362-f3lp10lm	248	21	the	the	DT
cord-301362-f3lp10lm	248	22	viral	viral	JJ
cord-301362-f3lp10lm	248	23	replication	replication	NN
cord-301362-f3lp10lm	248	24	complex	complex	NN
cord-301362-f3lp10lm	248	25	(	(	-LRB-
cord-301362-f3lp10lm	248	26	RdRp	RdRp	NNP
cord-301362-f3lp10lm	248	27	)	)	-RRB-
cord-301362-f3lp10lm	248	28	,	,	,
cord-301362-f3lp10lm	248	29	which	which	WDT
cord-301362-f3lp10lm	248	30	binds	bind	VBZ
cord-301362-f3lp10lm	248	31	to	to	IN
cord-301362-f3lp10lm	248	32	the	the	DT
cord-301362-f3lp10lm	248	33	plasma	plasma	NN
cord-301362-f3lp10lm	248	34	membrane	membrane	NN
cord-301362-f3lp10lm	248	35	to	to	TO
cord-301362-f3lp10lm	248	36	build	build	VB
cord-301362-f3lp10lm	248	37	up	up	RP
cord-301362-f3lp10lm	248	38	the	the	DT
cord-301362-f3lp10lm	248	39	membranous	membranous	JJ
cord-301362-f3lp10lm	248	40	niche	niche	NN
cord-301362-f3lp10lm	248	41	called	call	VBN
cord-301362-f3lp10lm	248	42	spherule	spherule	NNP
cord-301362-f3lp10lm	248	43	.	.	.
cord-301362-f3lp10lm	249	1	Once	once	RB
cord-301362-f3lp10lm	249	2	there	there	RB
cord-301362-f3lp10lm	249	3	,	,	,
cord-301362-f3lp10lm	249	4	the	the	DT
cord-301362-f3lp10lm	249	5	replicase	replicase	NN
cord-301362-f3lp10lm	249	6	activity	activity	NN
cord-301362-f3lp10lm	249	7	generates	generate	VBZ
cord-301362-f3lp10lm	249	8	new	new	JJ
cord-301362-f3lp10lm	249	9	viral	viral	JJ
cord-301362-f3lp10lm	249	10	genome	genome	NN
cord-301362-f3lp10lm	249	11	copies	copy	NNS
cord-301362-f3lp10lm	249	12	producing	produce	VBG
cord-301362-f3lp10lm	249	13	double	double	RB
cord-301362-f3lp10lm	249	14	-	-	HYPH
cord-301362-f3lp10lm	249	15	stranded	strand	VBN
cord-301362-f3lp10lm	249	16	RNA	RNA	NNP
cord-301362-f3lp10lm	249	17	(	(	-LRB-
cord-301362-f3lp10lm	249	18	dsRNA	dsrna	NN
cord-301362-f3lp10lm	249	19	)	)	-RRB-
cord-301362-f3lp10lm	249	20	molecules	molecule	NNS
cord-301362-f3lp10lm	249	21	as	as	IN
cord-301362-f3lp10lm	249	22	intermediates	intermediate	NNS
cord-301362-f3lp10lm	249	23	,	,	,
cord-301362-f3lp10lm	249	24	which	which	WDT
cord-301362-f3lp10lm	249	25	remain	remain	VBP
cord-301362-f3lp10lm	249	26	hided	hided	JJ
cord-301362-f3lp10lm	249	27	from	from	IN
cord-301362-f3lp10lm	249	28	the	the	DT
cord-301362-f3lp10lm	249	29	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	249	30	sentries	sentry	NNS
cord-301362-f3lp10lm	249	31	inside	inside	IN
cord-301362-f3lp10lm	249	32	the	the	DT
cord-301362-f3lp10lm	249	33	spherules	spherule	NNS
cord-301362-f3lp10lm	249	34	(	(	-LRB-
cord-301362-f3lp10lm	249	35	1	1	CD
cord-301362-f3lp10lm	249	36	)	)	-RRB-
cord-301362-f3lp10lm	249	37	.	.	.
cord-301362-f3lp10lm	250	1	Nevertheless	nevertheless	RB
cord-301362-f3lp10lm	250	2	,	,	,
cord-301362-f3lp10lm	250	3	in	in	IN
cord-301362-f3lp10lm	250	4	the	the	DT
cord-301362-f3lp10lm	250	5	meantime	meantime	NN
cord-301362-f3lp10lm	250	6	,	,	,
cord-301362-f3lp10lm	250	7	the	the	DT
cord-301362-f3lp10lm	250	8	RdRp	RdRp	NNP
cord-301362-f3lp10lm	250	9	is	be	VBZ
cord-301362-f3lp10lm	250	10	able	able	JJ
cord-301362-f3lp10lm	250	11	to	to	TO
cord-301362-f3lp10lm	250	12	take	take	VB
cord-301362-f3lp10lm	250	13	cellular	cellular	JJ
cord-301362-f3lp10lm	250	14	mRNA	mrna	NN
cord-301362-f3lp10lm	250	15	as	as	IN
cord-301362-f3lp10lm	250	16	template	template	NN
cord-301362-f3lp10lm	250	17	originating	originate	VBG
cord-301362-f3lp10lm	250	18	dsRNA	dsrna	NN
cord-301362-f3lp10lm	250	19	molecules	molecule	NNS
cord-301362-f3lp10lm	250	20	in	in	IN
cord-301362-f3lp10lm	250	21	the	the	DT
cord-301362-f3lp10lm	250	22	cytoplasm	cytoplasm	NN
cord-301362-f3lp10lm	250	23	,	,	,
cord-301362-f3lp10lm	250	24	exposed	expose	VBN
cord-301362-f3lp10lm	250	25	to	to	IN
cord-301362-f3lp10lm	250	26	the	the	DT
cord-301362-f3lp10lm	250	27	Pamp	Pamp	NNP
cord-301362-f3lp10lm	250	28	Recognition	Recognition	NNP
cord-301362-f3lp10lm	250	29	Receptors	Receptors	NNPS
cord-301362-f3lp10lm	250	30	[	[	-LRB-
cord-301362-f3lp10lm	250	31	PRRs	prr	NNS
cord-301362-f3lp10lm	250	32	(	(	-LRB-
cord-301362-f3lp10lm	250	33	MDA-5	MDA-5	NNP
cord-301362-f3lp10lm	250	34	and	and	CC
cord-301362-f3lp10lm	250	35	RIG	rig	NN
cord-301362-f3lp10lm	250	36	-	-	:
cord-301362-f3lp10lm	250	37	I	i	NN
cord-301362-f3lp10lm	250	38	)	)	-RRB-
cord-301362-f3lp10lm	250	39	]	]	-RRB-
cord-301362-f3lp10lm	250	40	to	to	TO
cord-301362-f3lp10lm	250	41	initiate	initiate	VB
cord-301362-f3lp10lm	250	42	the	the	DT
cord-301362-f3lp10lm	250	43	innate	innate	JJ
cord-301362-f3lp10lm	250	44	immune	immune	JJ
cord-301362-f3lp10lm	250	45	response	response	NN
cord-301362-f3lp10lm	250	46	,	,	,
cord-301362-f3lp10lm	250	47	which	which	WDT
cord-301362-f3lp10lm	250	48	produces	produce	VBZ
cord-301362-f3lp10lm	250	49	the	the	DT
cord-301362-f3lp10lm	250	50	viral	viral	JJ
cord-301362-f3lp10lm	250	51	restriction	restriction	NN
cord-301362-f3lp10lm	250	52	(	(	-LRB-
cord-301362-f3lp10lm	250	53	2	2	CD
cord-301362-f3lp10lm	250	54	)	)	-RRB-
cord-301362-f3lp10lm	250	55	.	.	.
cord-301362-f3lp10lm	251	1	missing	miss	VBG
cord-301362-f3lp10lm	251	2	.	.	.
cord-301362-f3lp10lm	252	1	For	for	IN
cord-301362-f3lp10lm	252	2	instance	instance	NN
cord-301362-f3lp10lm	252	3	,	,	,
cord-301362-f3lp10lm	252	4	the	the	DT
cord-301362-f3lp10lm	252	5	exact	exact	JJ
cord-301362-f3lp10lm	252	6	topology	topology	NN
cord-301362-f3lp10lm	252	7	of	of	IN
cord-301362-f3lp10lm	252	8	RNA	RNA	NNP
cord-301362-f3lp10lm	252	9	replication	replication	NN
cord-301362-f3lp10lm	252	10	sites	site	NNS
cord-301362-f3lp10lm	252	11	for	for	IN
cord-301362-f3lp10lm	252	12	DMV	DMV	NNP
cord-301362-f3lp10lm	252	13	-	-	HYPH
cord-301362-f3lp10lm	252	14	type	type	NN
cord-301362-f3lp10lm	252	15	replication	replication	NN
cord-301362-f3lp10lm	252	16	factories	factory	NNS
cord-301362-f3lp10lm	252	17	is	be	VBZ
cord-301362-f3lp10lm	252	18	yet	yet	RB
cord-301362-f3lp10lm	252	19	uncharacterized	uncharacterized	JJ
cord-301362-f3lp10lm	252	20	.	.	.
cord-301362-f3lp10lm	253	1	Indeed	indeed	RB
cord-301362-f3lp10lm	253	2	,	,	,
cord-301362-f3lp10lm	253	3	novel	novel	JJ
cord-301362-f3lp10lm	253	4	experimental	experimental	JJ
cord-301362-f3lp10lm	253	5	techniques	technique	NNS
cord-301362-f3lp10lm	253	6	such	such	JJ
cord-301362-f3lp10lm	253	7	as	as	IN
cord-301362-f3lp10lm	253	8	metabolic	metabolic	JJ
cord-301362-f3lp10lm	253	9	in	in	IN
cord-301362-f3lp10lm	253	10	situ	situ	JJ
cord-301362-f3lp10lm	253	11	labeling	labeling	NN
cord-301362-f3lp10lm	253	12	of	of	IN
cord-301362-f3lp10lm	253	13	nascent	nascent	JJ
cord-301362-f3lp10lm	253	14	viral	viral	JJ
cord-301362-f3lp10lm	253	15	RNA	RNA	NNP
cord-301362-f3lp10lm	253	16	and	and	CC
cord-301362-f3lp10lm	253	17	its	-PRON-	PRP$
cord-301362-f3lp10lm	253	18	visualization	visualization	NN
cord-301362-f3lp10lm	253	19	by	by	IN
cord-301362-f3lp10lm	253	20	employing	employ	VBG
cord-301362-f3lp10lm	253	21	high	high	JJ
cord-301362-f3lp10lm	253	22	resolution	resolution	NN
cord-301362-f3lp10lm	253	23	and	and	CC
cord-301362-f3lp10lm	253	24	specific	specific	JJ
cord-301362-f3lp10lm	253	25	microscopy	microscopy	NN
cord-301362-f3lp10lm	253	26	methods	method	NNS
cord-301362-f3lp10lm	253	27	will	will	MD
cord-301362-f3lp10lm	253	28	help	help	VB
cord-301362-f3lp10lm	253	29	tackling	tackle	VBG
cord-301362-f3lp10lm	253	30	this	this	DT
cord-301362-f3lp10lm	253	31	important	important	JJ
cord-301362-f3lp10lm	253	32	feature	feature	NN
cord-301362-f3lp10lm	253	33	of	of	IN
cord-301362-f3lp10lm	253	34	+	+	SYM
cord-301362-f3lp10lm	253	35	sRNA	srna	NN
cord-301362-f3lp10lm	253	36	viruses	virus	NNS
cord-301362-f3lp10lm	253	37	replication	replication	NN
cord-301362-f3lp10lm	253	38	.	.	.
cord-301362-f3lp10lm	254	1	Membrane	membrane	NN
cord-301362-f3lp10lm	254	2	-	-	HYPH
cord-301362-f3lp10lm	254	3	remodeling	remodel	VBG
cord-301362-f3lp10lm	254	4	events	event	NNS
cord-301362-f3lp10lm	254	5	responsible	responsible	JJ
cord-301362-f3lp10lm	254	6	for	for	IN
cord-301362-f3lp10lm	254	7	the	the	DT
cord-301362-f3lp10lm	254	8	biogenesis	biogenesis	NN
cord-301362-f3lp10lm	254	9	of	of	IN
cord-301362-f3lp10lm	254	10	replication	replication	NN
cord-301362-f3lp10lm	254	11	factories	factory	NNS
cord-301362-f3lp10lm	254	12	are	be	VBP
cord-301362-f3lp10lm	254	13	also	also	RB
cord-301362-f3lp10lm	254	14	mostly	mostly	RB
cord-301362-f3lp10lm	254	15	unknown	unknown	JJ
cord-301362-f3lp10lm	254	16	.	.	.
cord-301362-f3lp10lm	255	1	It	-PRON-	PRP
cord-301362-f3lp10lm	255	2	is	be	VBZ
cord-301362-f3lp10lm	255	3	likely	likely	JJ
cord-301362-f3lp10lm	255	4	that	that	IN
cord-301362-f3lp10lm	255	5	a	a	DT
cord-301362-f3lp10lm	255	6	viral	viral	JJ
cord-301362-f3lp10lm	255	7	protein	protein	NN
cord-301362-f3lp10lm	255	8	interplaying	interplaye	VBG
cord-301362-f3lp10lm	255	9	with	with	IN
cord-301362-f3lp10lm	255	10	cellular	cellular	JJ
cord-301362-f3lp10lm	255	11	factors	factor	NNS
cord-301362-f3lp10lm	255	12	might	may	MD
cord-301362-f3lp10lm	255	13	be	be	VB
cord-301362-f3lp10lm	255	14	responsible	responsible	JJ
cord-301362-f3lp10lm	255	15	for	for	IN
cord-301362-f3lp10lm	255	16	that	that	DT
cord-301362-f3lp10lm	255	17	,	,	,
cord-301362-f3lp10lm	255	18	but	but	CC
cord-301362-f3lp10lm	255	19	precise	precise	JJ
cord-301362-f3lp10lm	255	20	contributions	contribution	NNS
cord-301362-f3lp10lm	255	21	of	of	IN
cord-301362-f3lp10lm	255	22	individual	individual	JJ
cord-301362-f3lp10lm	255	23	factors	factor	NNS
cord-301362-f3lp10lm	255	24	and	and	CC
cord-301362-f3lp10lm	255	25	their	-PRON-	PRP$
cord-301362-f3lp10lm	255	26	temporal	temporal	JJ
cord-301362-f3lp10lm	255	27	and	and	CC
cord-301362-f3lp10lm	255	28	spatial	spatial	JJ
cord-301362-f3lp10lm	255	29	coordination	coordination	NN
cord-301362-f3lp10lm	255	30	remain	remain	VBP
cord-301362-f3lp10lm	255	31	to	to	TO
cord-301362-f3lp10lm	255	32	be	be	VB
cord-301362-f3lp10lm	255	33	discovered	discover	VBN
cord-301362-f3lp10lm	255	34	.	.	.
cord-301362-f3lp10lm	256	1	Nevertheless	nevertheless	RB
cord-301362-f3lp10lm	256	2	,	,	,
cord-301362-f3lp10lm	256	3	cellular	cellular	JJ
cord-301362-f3lp10lm	256	4	host	host	NN
cord-301362-f3lp10lm	256	5	is	be	VBZ
cord-301362-f3lp10lm	256	6	able	able	JJ
cord-301362-f3lp10lm	256	7	to	to	TO
cord-301362-f3lp10lm	256	8	develop	develop	VB
cord-301362-f3lp10lm	256	9	an	an	DT
cord-301362-f3lp10lm	256	10	innate	innate	JJ
cord-301362-f3lp10lm	256	11	immune	immune	JJ
cord-301362-f3lp10lm	256	12	response	response	NN
cord-301362-f3lp10lm	256	13	mediated	mediate	VBN
cord-301362-f3lp10lm	256	14	by	by	IN
cord-301362-f3lp10lm	256	15	PRRs	prr	NNS
cord-301362-f3lp10lm	256	16	without	without	IN
cord-301362-f3lp10lm	256	17	needing	need	VBG
cord-301362-f3lp10lm	256	18	viral	viral	JJ
cord-301362-f3lp10lm	256	19	replication	replication	NN
cord-301362-f3lp10lm	256	20	,	,	,
cord-301362-f3lp10lm	256	21	which	which	WDT
cord-301362-f3lp10lm	256	22	have	have	VBP
cord-301362-f3lp10lm	256	23	placed	place	VBN
cord-301362-f3lp10lm	256	24	the	the	DT
cord-301362-f3lp10lm	256	25	pressure	pressure	NN
cord-301362-f3lp10lm	256	26	back	back	RB
cord-301362-f3lp10lm	256	27	on	on	IN
cord-301362-f3lp10lm	256	28	viral	viral	JJ
cord-301362-f3lp10lm	256	29	agents	agent	NNS
cord-301362-f3lp10lm	256	30	to	to	TO
cord-301362-f3lp10lm	256	31	evolve	evolve	VB
cord-301362-f3lp10lm	256	32	specific	specific	JJ
cord-301362-f3lp10lm	256	33	strategies	strategy	NNS
cord-301362-f3lp10lm	256	34	to	to	TO
cord-301362-f3lp10lm	256	35	counteract	counteract	VB
cord-301362-f3lp10lm	256	36	its	-PRON-	PRP$
cord-301362-f3lp10lm	256	37	action	action	NN
cord-301362-f3lp10lm	256	38	,	,	,
cord-301362-f3lp10lm	256	39	while	while	IN
cord-301362-f3lp10lm	256	40	allowing	allow	VBG
cord-301362-f3lp10lm	256	41	the	the	DT
cord-301362-f3lp10lm	256	42	viral	viral	JJ
cord-301362-f3lp10lm	256	43	genome	genome	NN
cord-301362-f3lp10lm	256	44	to	to	TO
cord-301362-f3lp10lm	256	45	replicate	replicate	VB
cord-301362-f3lp10lm	256	46	inside	inside	IN
cord-301362-f3lp10lm	256	47	their	-PRON-	PRP$
cord-301362-f3lp10lm	256	48	hideouts	hideout	NNS
cord-301362-f3lp10lm	256	49	.	.	.
cord-301362-f3lp10lm	257	1	LD	LD	NNP
cord-301362-f3lp10lm	257	2	and	and	CC
cord-301362-f3lp10lm	257	3	MC	MC	NNP
cord-301362-f3lp10lm	257	4	together	together	RB
cord-301362-f3lp10lm	257	5	built	build	VBD
cord-301362-f3lp10lm	257	6	up	up	RP
cord-301362-f3lp10lm	257	7	the	the	DT
cord-301362-f3lp10lm	257	8	idea	idea	NN
cord-301362-f3lp10lm	257	9	and	and	CC
cord-301362-f3lp10lm	257	10	structure	structure	NN
cord-301362-f3lp10lm	257	11	of	of	IN
cord-301362-f3lp10lm	257	12	the	the	DT
cord-301362-f3lp10lm	257	13	review	review	NN
cord-301362-f3lp10lm	257	14	.	.	.
cord-301362-f3lp10lm	258	1	LD	LD	NNP
cord-301362-f3lp10lm	258	2	wrote	write	VBD
cord-301362-f3lp10lm	258	3	the	the	DT
cord-301362-f3lp10lm	258	4	majority	majority	NN
cord-301362-f3lp10lm	258	5	of	of	IN
cord-301362-f3lp10lm	258	6	the	the	DT
cord-301362-f3lp10lm	258	7	text	text	NN
cord-301362-f3lp10lm	258	8	.	.	.
cord-301362-f3lp10lm	259	1	MC	MC	NNP
cord-301362-f3lp10lm	259	2	wrote	write	VBD
cord-301362-f3lp10lm	259	3	a	a	DT
cord-301362-f3lp10lm	259	4	section	section	NN
cord-301362-f3lp10lm	259	5	of	of	IN
cord-301362-f3lp10lm	259	6	the	the	DT
cord-301362-f3lp10lm	259	7	review	review	NN
cord-301362-f3lp10lm	259	8	and	and	CC
cord-301362-f3lp10lm	259	9	helped	help	VBD
cord-301362-f3lp10lm	259	10	performing	perform	VBG
cord-301362-f3lp10lm	259	11	the	the	DT
cord-301362-f3lp10lm	259	12	revision	revision	NN
cord-301362-f3lp10lm	259	13	of	of	IN
cord-301362-f3lp10lm	259	14	the	the	DT
cord-301362-f3lp10lm	259	15	manuscript	manuscript	NN
cord-301362-f3lp10lm	259	16	to	to	IN
cord-301362-f3lp10lm	259	17	its	-PRON-	PRP$
cord-301362-f3lp10lm	259	18	final	final	JJ
cord-301362-f3lp10lm	259	19	version	version	NN
cord-301362-f3lp10lm	259	20	.	.	.
cord-301362-f3lp10lm	260	1	Semliki	Semliki	NNP
cord-301362-f3lp10lm	260	2	Forest	Forest	NNP
cord-301362-f3lp10lm	260	3	virus	virus	NN
cord-301362-f3lp10lm	261	1	mRNA	mrna	NN
cord-301362-f3lp10lm	261	2	capping	cap	VBG
cord-301362-f3lp10lm	261	3	enzyme	enzyme	NN
cord-301362-f3lp10lm	261	4	requires	require	VBZ
cord-301362-f3lp10lm	261	5	association	association	NN
cord-301362-f3lp10lm	261	6	with	with	IN
cord-301362-f3lp10lm	261	7	anionic	anionic	JJ
cord-301362-f3lp10lm	261	8	membrane	membrane	NN
cord-301362-f3lp10lm	261	9	phospholipids	phospholipid	NNS
cord-301362-f3lp10lm	261	10	for	for	IN
cord-301362-f3lp10lm	261	11	activity	activity	NN
cord-301362-f3lp10lm	261	12	Recognition	recognition	NN
cord-301362-f3lp10lm	261	13	of	of	IN
cord-301362-f3lp10lm	261	14	double	double	RB
cord-301362-f3lp10lm	261	15	-	-	HYPH
cord-301362-f3lp10lm	261	16	stranded	strand	VBN
cord-301362-f3lp10lm	261	17	RNA	RNA	NNP
cord-301362-f3lp10lm	261	18	and	and	CC
cord-301362-f3lp10lm	261	19	activation	activation	NN
cord-301362-f3lp10lm	261	20	of	of	IN
cord-301362-f3lp10lm	261	21	NF	NF	NNP
cord-301362-f3lp10lm	261	22	-	-	HYPH
cord-301362-f3lp10lm	261	23	kappaB	kappaB	NNP
cord-301362-f3lp10lm	261	24	by	by	IN
cord-301362-f3lp10lm	261	25	Toll	Toll	NNP
cord-301362-f3lp10lm	261	26	-	-	HYPH
cord-301362-f3lp10lm	261	27	like	like	JJ
cord-301362-f3lp10lm	261	28	receptor	receptor	NN
cord-301362-f3lp10lm	261	29	3	3	CD
cord-301362-f3lp10lm	261	30	Valosin	Valosin	NNP
cord-301362-f3lp10lm	261	31	-	-	HYPH
cord-301362-f3lp10lm	261	32	containing	contain	VBG
cord-301362-f3lp10lm	261	33	protein	protein	NN
cord-301362-f3lp10lm	261	34	(	(	-LRB-
cord-301362-f3lp10lm	261	35	VCP	VCP	NNP
cord-301362-f3lp10lm	261	36	/	/	SYM
cord-301362-f3lp10lm	261	37	p97	p97	CD
cord-301362-f3lp10lm	261	38	)	)	-RRB-
cord-301362-f3lp10lm	261	39	is	be	VBZ
cord-301362-f3lp10lm	261	40	required	require	VBN
cord-301362-f3lp10lm	261	41	for	for	IN
cord-301362-f3lp10lm	261	42	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	261	43	replication	replication	NN
cord-301362-f3lp10lm	261	44	and	and	CC
cord-301362-f3lp10lm	261	45	is	be	VBZ
cord-301362-f3lp10lm	261	46	involved	involve	VBN
cord-301362-f3lp10lm	261	47	in	in	IN
cord-301362-f3lp10lm	261	48	cellular	cellular	JJ
cord-301362-f3lp10lm	261	49	protein	protein	NN
cord-301362-f3lp10lm	261	50	secretion	secretion	NN
cord-301362-f3lp10lm	261	51	pathway	pathway	NN
cord-301362-f3lp10lm	261	52	in	in	IN
cord-301362-f3lp10lm	261	53	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	261	54	infection	infection	NN
cord-301362-f3lp10lm	262	1	The	the	DT
cord-301362-f3lp10lm	262	2	molecular	molecular	JJ
cord-301362-f3lp10lm	262	3	pathogenesis	pathogenesis	NN
cord-301362-f3lp10lm	262	4	of	of	IN
cord-301362-f3lp10lm	262	5	Semliki	Semliki	NNP
cord-301362-f3lp10lm	262	6	Forest	Forest	NNP
cord-301362-f3lp10lm	262	7	virus	virus	NN
cord-301362-f3lp10lm	262	8	:	:	:
cord-301362-f3lp10lm	262	9	a	a	DT
cord-301362-f3lp10lm	262	10	model	model	NN
cord-301362-f3lp10lm	262	11	virus	virus	NN
cord-301362-f3lp10lm	262	12	made	make	VBD
cord-301362-f3lp10lm	262	13	useful	useful	JJ
cord-301362-f3lp10lm	262	14	?	?	.
cord-301362-f3lp10lm	263	1	Subcellular	subcellular	JJ
cord-301362-f3lp10lm	263	2	localization	localization	NN
cord-301362-f3lp10lm	263	3	and	and	CC
cord-301362-f3lp10lm	263	4	rearrangement	rearrangement	NN
cord-301362-f3lp10lm	263	5	of	of	IN
cord-301362-f3lp10lm	263	6	endoplasmic	endoplasmic	NN
cord-301362-f3lp10lm	263	7	reticulum	reticulum	NN
cord-301362-f3lp10lm	263	8	by	by	IN
cord-301362-f3lp10lm	263	9	Brome	Brome	NNP
cord-301362-f3lp10lm	263	10	mosaic	mosaic	JJ
cord-301362-f3lp10lm	263	11	virus	virus	NN
cord-301362-f3lp10lm	263	12	capsid	capsid	NN
cord-301362-f3lp10lm	263	13	protein	protein	NN
cord-301362-f3lp10lm	263	14	Hijacking	hijacking	NN
cord-301362-f3lp10lm	263	15	components	component	NNS
cord-301362-f3lp10lm	263	16	of	of	IN
cord-301362-f3lp10lm	263	17	the	the	DT
cord-301362-f3lp10lm	263	18	cellular	cellular	JJ
cord-301362-f3lp10lm	263	19	secretory	secretory	JJ
cord-301362-f3lp10lm	263	20	pathway	pathway	NN
cord-301362-f3lp10lm	263	21	for	for	IN
cord-301362-f3lp10lm	263	22	replication	replication	NN
cord-301362-f3lp10lm	263	23	of	of	IN
cord-301362-f3lp10lm	263	24	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	263	25	RNA	RNA	NNP
cord-301362-f3lp10lm	263	26	Poliovirus	Poliovirus	NNP
cord-301362-f3lp10lm	263	27	proteins	protein	NNS
cord-301362-f3lp10lm	263	28	induce	induce	VBP
cord-301362-f3lp10lm	263	29	membrane	membrane	NN
cord-301362-f3lp10lm	263	30	association	association	NN
cord-301362-f3lp10lm	263	31	of	of	IN
cord-301362-f3lp10lm	263	32	GTPase	GTPase	NNP
cord-301362-f3lp10lm	263	33	ADP	ADP	NNP
cord-301362-f3lp10lm	263	34	-	-	HYPH
cord-301362-f3lp10lm	263	35	ribosylation	ribosylation	NN
cord-301362-f3lp10lm	263	36	factor	factor	NN
cord-301362-f3lp10lm	264	1	Complex	complex	JJ
cord-301362-f3lp10lm	264	2	dynamic	dynamic	JJ
cord-301362-f3lp10lm	264	3	development	development	NN
cord-301362-f3lp10lm	264	4	of	of	IN
cord-301362-f3lp10lm	264	5	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	264	6	membranous	membranous	JJ
cord-301362-f3lp10lm	264	7	replication	replication	NN
cord-301362-f3lp10lm	264	8	complexes	complex	NNS
cord-301362-f3lp10lm	264	9	MDA5	MDA5	NNP
cord-301362-f3lp10lm	264	10	cooperatively	cooperatively	RB
cord-301362-f3lp10lm	264	11	forms	form	VBZ
cord-301362-f3lp10lm	264	12	dimers	dimer	NNS
cord-301362-f3lp10lm	264	13	and	and	CC
cord-301362-f3lp10lm	264	14	ATP	ATP	NNP
cord-301362-f3lp10lm	264	15	-	-	HYPH
cord-301362-f3lp10lm	264	16	sensitive	sensitive	JJ
cord-301362-f3lp10lm	264	17	filaments	filament	NNS
cord-301362-f3lp10lm	264	18	upon	upon	IN
cord-301362-f3lp10lm	264	19	binding	bind	VBG
cord-301362-f3lp10lm	264	20	double	double	RB
cord-301362-f3lp10lm	264	21	-	-	HYPH
cord-301362-f3lp10lm	264	22	stranded	strand	VBN
cord-301362-f3lp10lm	264	23	RNA	RNA	NNP
cord-301362-f3lp10lm	264	24	Nonlytic	Nonlytic	NNP
cord-301362-f3lp10lm	264	25	viral	viral	JJ
cord-301362-f3lp10lm	264	26	spread	spread	NN
cord-301362-f3lp10lm	264	27	enhanced	enhance	VBN
cord-301362-f3lp10lm	264	28	by	by	IN
cord-301362-f3lp10lm	264	29	autophagy	autophagy	NN
cord-301362-f3lp10lm	264	30	components	component	NNS
cord-301362-f3lp10lm	265	1	Viral	viral	JJ
cord-301362-f3lp10lm	265	2	evasion	evasion	NN
cord-301362-f3lp10lm	265	3	and	and	CC
cord-301362-f3lp10lm	265	4	subversion	subversion	NN
cord-301362-f3lp10lm	265	5	of	of	IN
cord-301362-f3lp10lm	265	6	pattern	pattern	NN
cord-301362-f3lp10lm	265	7	-	-	HYPH
cord-301362-f3lp10lm	265	8	recognition	recognition	NN
cord-301362-f3lp10lm	265	9	receptor	receptor	NN
cord-301362-f3lp10lm	265	10	signalling	signal	VBG
cord-301362-f3lp10lm	265	11	Morphogenesis	Morphogenesis	NNP
cord-301362-f3lp10lm	265	12	of	of	IN
cord-301362-f3lp10lm	265	13	endoplasmic	endoplasmic	NN
cord-301362-f3lp10lm	265	14	reticulum	reticulum	NN
cord-301362-f3lp10lm	265	15	membrane	membrane	NN
cord-301362-f3lp10lm	265	16	-	-	HYPH
cord-301362-f3lp10lm	265	17	invaginated	invaginate	VBN
cord-301362-f3lp10lm	265	18	vesicles	vesicle	NNS
cord-301362-f3lp10lm	265	19	during	during	IN
cord-301362-f3lp10lm	265	20	beet	beet	NN
cord-301362-f3lp10lm	265	21	black	black	JJ
cord-301362-f3lp10lm	265	22	scorch	scorch	VBP
cord-301362-f3lp10lm	265	23	virus	virus	NN
cord-301362-f3lp10lm	265	24	infection	infection	NN
cord-301362-f3lp10lm	265	25	:	:	:
cord-301362-f3lp10lm	265	26	role	role	NN
cord-301362-f3lp10lm	265	27	of	of	IN
cord-301362-f3lp10lm	265	28	auxiliary	auxiliary	JJ
cord-301362-f3lp10lm	265	29	replication	replication	NN
cord-301362-f3lp10lm	265	30	protein	protein	NN
cord-301362-f3lp10lm	265	31	and	and	CC
cord-301362-f3lp10lm	265	32	new	new	JJ
cord-301362-f3lp10lm	265	33	implications	implication	NNS
cord-301362-f3lp10lm	265	34	of	of	IN
cord-301362-f3lp10lm	265	35	three	three	CD
cord-301362-f3lp10lm	265	36	-	-	HYPH
cord-301362-f3lp10lm	265	37	dimensional	dimensional	JJ
cord-301362-f3lp10lm	265	38	architecture	architecture	NN
cord-301362-f3lp10lm	265	39	Phosphatidylserine	phosphatidylserine	NN
cord-301362-f3lp10lm	265	40	vesicles	vesicle	NNS
cord-301362-f3lp10lm	265	41	enable	enable	VBP
cord-301362-f3lp10lm	265	42	efficient	efficient	JJ
cord-301362-f3lp10lm	265	43	en	en	IN
cord-301362-f3lp10lm	265	44	bloc	bloc	NNP
cord-301362-f3lp10lm	265	45	transmission	transmission	NN
cord-301362-f3lp10lm	265	46	of	of	IN
cord-301362-f3lp10lm	265	47	enteroviruses	enteroviruses	NNP
cord-301362-f3lp10lm	265	48	Electron	Electron	NNP
cord-301362-f3lp10lm	265	49	microscopic	microscopic	JJ
cord-301362-f3lp10lm	265	50	study	study	NN
cord-301362-f3lp10lm	265	51	of	of	IN
cord-301362-f3lp10lm	265	52	the	the	DT
cord-301362-f3lp10lm	265	53	formation	formation	NN
cord-301362-f3lp10lm	265	54	of	of	IN
cord-301362-f3lp10lm	265	55	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	265	56	IKKepsilon	IKKepsilon	NNP
cord-301362-f3lp10lm	265	57	and	and	CC
cord-301362-f3lp10lm	265	58	TBK1	TBK1	NNP
cord-301362-f3lp10lm	265	59	are	be	VBP
cord-301362-f3lp10lm	265	60	essential	essential	JJ
cord-301362-f3lp10lm	265	61	components	component	NNS
cord-301362-f3lp10lm	265	62	of	of	IN
cord-301362-f3lp10lm	265	63	the	the	DT
cord-301362-f3lp10lm	265	64	IRF3	IRF3	NNP
cord-301362-f3lp10lm	265	65	signaling	signal	VBG
cord-301362-f3lp10lm	265	66	pathway	pathway	NN
cord-301362-f3lp10lm	265	67	Three	three	CD
cord-301362-f3lp10lm	265	68	-	-	HYPH
cord-301362-f3lp10lm	265	69	dimensional	dimensional	JJ
cord-301362-f3lp10lm	265	70	structure	structure	NN
cord-301362-f3lp10lm	265	71	of	of	IN
cord-301362-f3lp10lm	265	72	Rubella	rubella	NN
cord-301362-f3lp10lm	265	73	virus	virus	NN
cord-301362-f3lp10lm	265	74	factories	factory	NNS
cord-301362-f3lp10lm	265	75	Electron	Electron	NNP
cord-301362-f3lp10lm	265	76	tomography	tomography	NN
cord-301362-f3lp10lm	265	77	of	of	IN
cord-301362-f3lp10lm	265	78	membrane	membrane	NN
cord-301362-f3lp10lm	265	79	-	-	HYPH
cord-301362-f3lp10lm	265	80	bound	bind	VBN
cord-301362-f3lp10lm	265	81	cellular	cellular	JJ
cord-301362-f3lp10lm	265	82	organelles	organelle	NNS
cord-301362-f3lp10lm	265	83	Cell	cell	NN
cord-301362-f3lp10lm	265	84	-	-	HYPH
cord-301362-f3lp10lm	265	85	induced	induce	VBN
cord-301362-f3lp10lm	265	86	conformational	conformational	JJ
cord-301362-f3lp10lm	265	87	change	change	NN
cord-301362-f3lp10lm	265	88	in	in	IN
cord-301362-f3lp10lm	265	89	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	265	90	:	:	:
cord-301362-f3lp10lm	265	91	externalization	externalization	NN
cord-301362-f3lp10lm	265	92	of	of	IN
cord-301362-f3lp10lm	265	93	the	the	DT
cord-301362-f3lp10lm	265	94	amino	amino	NN
cord-301362-f3lp10lm	265	95	terminus	terminus	NN
cord-301362-f3lp10lm	265	96	of	of	IN
cord-301362-f3lp10lm	265	97	VP1	VP1	NNP
cord-301362-f3lp10lm	265	98	is	be	VBZ
cord-301362-f3lp10lm	265	99	responsible	responsible	JJ
cord-301362-f3lp10lm	265	100	for	for	IN
cord-301362-f3lp10lm	265	101	liposome	liposome	NN
cord-301362-f3lp10lm	265	102	binding	bind	VBG
cord-301362-f3lp10lm	265	103	Cytoplasmic	Cytoplasmic	NNP
cord-301362-f3lp10lm	265	104	fractions	fraction	NNS
cord-301362-f3lp10lm	265	105	associated	associate	VBN
cord-301362-f3lp10lm	265	106	with	with	IN
cord-301362-f3lp10lm	265	107	Semliki	Semliki	NNP
cord-301362-f3lp10lm	265	108	Forest	Forest	NNP
cord-301362-f3lp10lm	265	109	virus	virus	NN
cord-301362-f3lp10lm	265	110	ribonucleic	ribonucleic	NN
cord-301362-f3lp10lm	265	111	acid	acid	NN
cord-301362-f3lp10lm	265	112	replication	replication	NN
cord-301362-f3lp10lm	265	113	Membrane	membrane	NN
cord-301362-f3lp10lm	265	114	-	-	HYPH
cord-301362-f3lp10lm	265	115	associated	associate	VBN
cord-301362-f3lp10lm	265	116	replication	replication	NN
cord-301362-f3lp10lm	265	117	complex	complex	NN
cord-301362-f3lp10lm	265	118	in	in	IN
cord-301362-f3lp10lm	265	119	arbovirus	arbovirus	NN
cord-301362-f3lp10lm	265	120	infection	infection	NN
cord-301362-f3lp10lm	265	121	Functional	Functional	NNP
cord-301362-f3lp10lm	265	122	Sindbis	Sindbis	NNP
cord-301362-f3lp10lm	265	123	virus	virus	NN
cord-301362-f3lp10lm	265	124	replicative	replicative	JJ
cord-301362-f3lp10lm	265	125	complexes	complex	NNS
cord-301362-f3lp10lm	265	126	are	be	VBP
cord-301362-f3lp10lm	265	127	formed	form	VBN
cord-301362-f3lp10lm	265	128	at	at	IN
cord-301362-f3lp10lm	265	129	the	the	DT
cord-301362-f3lp10lm	265	130	plasma	plasma	NN
cord-301362-f3lp10lm	265	131	membrane	membrane	NN
cord-301362-f3lp10lm	265	132	Alphavirus	Alphavirus	NNP
cord-301362-f3lp10lm	265	133	RNA	RNA	NNP
cord-301362-f3lp10lm	265	134	replicase	replicase	NN
cord-301362-f3lp10lm	265	135	is	be	VBZ
cord-301362-f3lp10lm	265	136	located	locate	VBN
cord-301362-f3lp10lm	265	137	on	on	IN
cord-301362-f3lp10lm	265	138	the	the	DT
cord-301362-f3lp10lm	265	139	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	265	140	surface	surface	NN
cord-301362-f3lp10lm	265	141	of	of	IN
cord-301362-f3lp10lm	265	142	endosomes	endosome	NNS
cord-301362-f3lp10lm	265	143	and	and	CC
cord-301362-f3lp10lm	265	144	lysosomes	lysosome	NNS
cord-301362-f3lp10lm	266	1	Virion	Virion	NNP
cord-301362-f3lp10lm	266	2	Structure	Structure	NNP
cord-301362-f3lp10lm	266	3	Triggering	trigger	VBG
cord-301362-f3lp10lm	266	4	antiviral	antiviral	JJ
cord-301362-f3lp10lm	266	5	response	response	NN
cord-301362-f3lp10lm	266	6	by	by	IN
cord-301362-f3lp10lm	266	7	RIG	rig	NN
cord-301362-f3lp10lm	266	8	-	-	HYPH
cord-301362-f3lp10lm	266	9	I	i	NN
cord-301362-f3lp10lm	266	10	-	-	HYPH
cord-301362-f3lp10lm	266	11	related	relate	VBN
cord-301362-f3lp10lm	266	12	RNA	RNA	NNP
cord-301362-f3lp10lm	266	13	helicases	helicase	NNS
cord-301362-f3lp10lm	266	14	Structure	Structure	NNP
cord-301362-f3lp10lm	266	15	and	and	CC
cord-301362-f3lp10lm	266	16	function	function	NN
cord-301362-f3lp10lm	266	17	of	of	IN
cord-301362-f3lp10lm	266	18	Toll	toll	NN
cord-301362-f3lp10lm	266	19	receptors	receptor	NNS
cord-301362-f3lp10lm	266	20	and	and	CC
cord-301362-f3lp10lm	266	21	their	-PRON-	PRP$
cord-301362-f3lp10lm	266	22	ligands	ligand	NNS
cord-301362-f3lp10lm	266	23	Conformational	Conformational	NNP
cord-301362-f3lp10lm	266	24	change	change	NN
cord-301362-f3lp10lm	266	25	and	and	CC
cord-301362-f3lp10lm	266	26	protein	protein	NN
cord-301362-f3lp10lm	266	27	-	-	HYPH
cord-301362-f3lp10lm	266	28	protein	protein	NN
cord-301362-f3lp10lm	266	29	interactions	interaction	NNS
cord-301362-f3lp10lm	266	30	of	of	IN
cord-301362-f3lp10lm	266	31	the	the	DT
cord-301362-f3lp10lm	266	32	fusion	fusion	NN
cord-301362-f3lp10lm	266	33	protein	protein	NN
cord-301362-f3lp10lm	266	34	of	of	IN
cord-301362-f3lp10lm	266	35	Semliki	Semliki	NNP
cord-301362-f3lp10lm	266	36	Forest	Forest	NNP
cord-301362-f3lp10lm	266	37	virus	virus	NN
cord-301362-f3lp10lm	266	38	Cytoplasmic	Cytoplasmic	NNP
cord-301362-f3lp10lm	266	39	structures	structure	NNS
cord-301362-f3lp10lm	266	40	associated	associate	VBN
cord-301362-f3lp10lm	266	41	with	with	IN
cord-301362-f3lp10lm	266	42	an	an	DT
cord-301362-f3lp10lm	266	43	arbovirus	arbovirus	NN
cord-301362-f3lp10lm	266	44	infection	infection	NN
cord-301362-f3lp10lm	266	45	:	:	:
cord-301362-f3lp10lm	266	46	loci	locus	NNS
cord-301362-f3lp10lm	266	47	of	of	IN
cord-301362-f3lp10lm	266	48	viral	viral	JJ
cord-301362-f3lp10lm	266	49	ribonucleic	ribonucleic	NN
cord-301362-f3lp10lm	266	50	acid	acid	NN
cord-301362-f3lp10lm	266	51	synthesis	synthesis	NN
cord-301362-f3lp10lm	266	52	Ultrastructure	Ultrastructure	NNP
cord-301362-f3lp10lm	266	53	of	of	IN
cord-301362-f3lp10lm	266	54	the	the	DT
cord-301362-f3lp10lm	266	55	replication	replication	NN
cord-301362-f3lp10lm	266	56	sites	site	NNS
cord-301362-f3lp10lm	266	57	of	of	IN
cord-301362-f3lp10lm	266	58	positive	positive	JJ
cord-301362-f3lp10lm	266	59	-	-	HYPH
cord-301362-f3lp10lm	266	60	strand	strand	NN
cord-301362-f3lp10lm	266	61	RNA	RNA	NNP
cord-301362-f3lp10lm	266	62	viruses	virus	NNS
cord-301362-f3lp10lm	267	1	5'-Triphosphate	5'-triphosphate	JJ
cord-301362-f3lp10lm	268	1	RNA	RNA	NNP
cord-301362-f3lp10lm	268	2	is	be	VBZ
cord-301362-f3lp10lm	268	3	the	the	DT
cord-301362-f3lp10lm	268	4	ligand	ligand	NN
cord-301362-f3lp10lm	268	5	for	for	IN
cord-301362-f3lp10lm	268	6	RIG	rig	NN
cord-301362-f3lp10lm	269	1	-I	-I	NFP
cord-301362-f3lp10lm	269	2	MAVS	MAVS	NNP
cord-301362-f3lp10lm	269	3	forms	form	VBZ
cord-301362-f3lp10lm	269	4	functional	functional	JJ
cord-301362-f3lp10lm	269	5	prion	prion	NN
cord-301362-f3lp10lm	269	6	-	-	HYPH
cord-301362-f3lp10lm	269	7	like	like	JJ
cord-301362-f3lp10lm	269	8	aggregates	aggregate	NNS
cord-301362-f3lp10lm	269	9	to	to	TO
cord-301362-f3lp10lm	269	10	activate	activate	VB
cord-301362-f3lp10lm	269	11	and	and	CC
cord-301362-f3lp10lm	269	12	propagate	propagate	VB
cord-301362-f3lp10lm	269	13	antiviral	antiviral	JJ
cord-301362-f3lp10lm	269	14	innate	innate	JJ
cord-301362-f3lp10lm	269	15	immune	immune	JJ
cord-301362-f3lp10lm	269	16	response	response	NN
cord-301362-f3lp10lm	270	1	Viral	viral	JJ
cord-301362-f3lp10lm	270	2	reorganization	reorganization	NN
cord-301362-f3lp10lm	270	3	of	of	IN
cord-301362-f3lp10lm	270	4	the	the	DT
cord-301362-f3lp10lm	270	5	secretory	secretory	JJ
cord-301362-f3lp10lm	270	6	pathway	pathway	NN
cord-301362-f3lp10lm	270	7	generates	generate	VBZ
cord-301362-f3lp10lm	270	8	distinct	distinct	JJ
cord-301362-f3lp10lm	270	9	organelles	organelle	NNS
cord-301362-f3lp10lm	270	10	for	for	IN
cord-301362-f3lp10lm	270	11	RNA	RNA	NNP
cord-301362-f3lp10lm	270	12	replication	replication	NN
cord-301362-f3lp10lm	270	13	Poliovirus	Poliovirus	NNP
cord-301362-f3lp10lm	270	14	-	-	HYPH
cord-301362-f3lp10lm	270	15	induced	induce	VBN
cord-301362-f3lp10lm	270	16	changes	change	NNS
cord-301362-f3lp10lm	270	17	in	in	IN
cord-301362-f3lp10lm	270	18	cellular	cellular	JJ
cord-301362-f3lp10lm	270	19	membranes	membrane	NNS
cord-301362-f3lp10lm	270	20	throughout	throughout	IN
cord-301362-f3lp10lm	270	21	infection	infection	NN
cord-301362-f3lp10lm	270	22	Subversion	subversion	NN
cord-301362-f3lp10lm	270	23	of	of	IN
cord-301362-f3lp10lm	270	24	cellular	cellular	JJ
cord-301362-f3lp10lm	270	25	autophagosomal	autophagosomal	NN
cord-301362-f3lp10lm	270	26	machinery	machinery	NN
cord-301362-f3lp10lm	270	27	by	by	IN
cord-301362-f3lp10lm	270	28	RNA	RNA	NNP
cord-301362-f3lp10lm	270	29	viruses	virus	NNS
cord-301362-f3lp10lm	271	1	Primary	primary	JJ
cord-301362-f3lp10lm	271	2	structural	structural	JJ
cord-301362-f3lp10lm	271	3	comparison	comparison	NN
cord-301362-f3lp10lm	271	4	of	of	IN
cord-301362-f3lp10lm	271	5	RNAdependent	RNAdependent	NNP
cord-301362-f3lp10lm	271	6	polymerases	polymerase	NNS
cord-301362-f3lp10lm	271	7	from	from	IN
cord-301362-f3lp10lm	271	8	plant	plant	NN
cord-301362-f3lp10lm	271	9	,	,	,
cord-301362-f3lp10lm	271	10	animal	animal	NN
cord-301362-f3lp10lm	271	11	and	and	CC
cord-301362-f3lp10lm	271	12	bacterial	bacterial	JJ
cord-301362-f3lp10lm	271	13	viruses	virus	NNS
cord-301362-f3lp10lm	271	14	Differential	differential	JJ
cord-301362-f3lp10lm	271	15	roles	role	NNS
cord-301362-f3lp10lm	271	16	of	of	IN
cord-301362-f3lp10lm	271	17	MDA5	MDA5	NNP
cord-301362-f3lp10lm	271	18	and	and	CC
cord-301362-f3lp10lm	271	19	RIG	rig	NN
cord-301362-f3lp10lm	272	1	-I	-i	DT
cord-301362-f3lp10lm	272	2	helicases	helicase	NNS
cord-301362-f3lp10lm	272	3	in	in	IN
cord-301362-f3lp10lm	272	4	the	the	DT
cord-301362-f3lp10lm	272	5	recognition	recognition	NN
cord-301362-f3lp10lm	272	6	of	of	IN
cord-301362-f3lp10lm	272	7	RNA	RNA	NNP
cord-301362-f3lp10lm	272	8	viruses	virus	NNS
cord-301362-f3lp10lm	273	1	The	the	DT
cord-301362-f3lp10lm	273	2	role	role	NN
cord-301362-f3lp10lm	273	3	of	of	IN
cord-301362-f3lp10lm	273	4	pattern	pattern	NN
cord-301362-f3lp10lm	273	5	-	-	HYPH
cord-301362-f3lp10lm	273	6	recognition	recognition	NN
cord-301362-f3lp10lm	273	7	receptors	receptor	NNS
cord-301362-f3lp10lm	273	8	in	in	IN
cord-301362-f3lp10lm	273	9	innate	innate	JJ
cord-301362-f3lp10lm	273	10	immunity	immunity	NN
cord-301362-f3lp10lm	273	11	:	:	:
cord-301362-f3lp10lm	273	12	update	update	NN
cord-301362-f3lp10lm	273	13	on	on	IN
cord-301362-f3lp10lm	273	14	Toll	Toll	NNP
cord-301362-f3lp10lm	273	15	-	-	HYPH
cord-301362-f3lp10lm	273	16	like	like	JJ
cord-301362-f3lp10lm	273	17	receptors	receptor	NNS
cord-301362-f3lp10lm	273	18	RIG	rig	VB
cord-301362-f3lp10lm	273	19	-	-	:
cord-301362-f3lp10lm	273	20	I	-PRON-	PRP
cord-301362-f3lp10lm	273	21	in	in	IN
cord-301362-f3lp10lm	273	22	RNA	RNA	NNP
cord-301362-f3lp10lm	273	23	virus	virus	NN
cord-301362-f3lp10lm	273	24	recognition	recognition	NN
cord-301362-f3lp10lm	274	1	Coxsackievirus	Coxsackievirus	NNP
cord-301362-f3lp10lm	274	2	infection	infection	NN
cord-301362-f3lp10lm	274	3	induces	induce	VBZ
cord-301362-f3lp10lm	274	4	autophagy	autophagy	NN
cord-301362-f3lp10lm	274	5	-	-	HYPH
cord-301362-f3lp10lm	274	6	like	like	JJ
cord-301362-f3lp10lm	274	7	vesicles	vesicle	NNS
cord-301362-f3lp10lm	274	8	and	and	CC
cord-301362-f3lp10lm	274	9	megaphagosomes	megaphagosome	NNS
cord-301362-f3lp10lm	274	10	in	in	IN
cord-301362-f3lp10lm	274	11	pancreatic	pancreatic	JJ
cord-301362-f3lp10lm	274	12	acinar	acinar	NN
cord-301362-f3lp10lm	274	13	cells	cell	NNS
cord-301362-f3lp10lm	274	14	in	in	IN
cord-301362-f3lp10lm	274	15	vivo	vivo	NNP
cord-301362-f3lp10lm	274	16	Alphavirus	Alphavirus	NNP
cord-301362-f3lp10lm	274	17	entry	entry	NN
cord-301362-f3lp10lm	274	18	and	and	CC
cord-301362-f3lp10lm	274	19	membrane	membrane	NN
cord-301362-f3lp10lm	274	20	fusion	fusion	NN
cord-301362-f3lp10lm	274	21	UNC93B1	unc93b1	NN
cord-301362-f3lp10lm	274	22	delivers	deliver	VBZ
cord-301362-f3lp10lm	274	23	nucleotide	nucleotide	NN
cord-301362-f3lp10lm	274	24	-	-	HYPH
cord-301362-f3lp10lm	274	25	sensing	sense	VBG
cord-301362-f3lp10lm	274	26	toll	toll	NN
cord-301362-f3lp10lm	274	27	-	-	HYPH
cord-301362-f3lp10lm	274	28	like	like	JJ
cord-301362-f3lp10lm	274	29	receptors	receptor	NNS
cord-301362-f3lp10lm	274	30	to	to	TO
cord-301362-f3lp10lm	274	31	endolysosomes	endolysosomes	VB
cord-301362-f3lp10lm	274	32	Three	three	CD
cord-301362-f3lp10lm	274	33	-	-	HYPH
cord-301362-f3lp10lm	274	34	dimensional	dimensional	JJ
cord-301362-f3lp10lm	274	35	analysis	analysis	NN
cord-301362-f3lp10lm	274	36	of	of	IN
cord-301362-f3lp10lm	274	37	a	a	DT
cord-301362-f3lp10lm	274	38	viral	viral	JJ
cord-301362-f3lp10lm	274	39	RNA	RNA	NNP
cord-301362-f3lp10lm	274	40	replication	replication	NN
cord-301362-f3lp10lm	274	41	complex	complex	NN
cord-301362-f3lp10lm	274	42	reveals	reveal	VBZ
cord-301362-f3lp10lm	274	43	a	a	DT
cord-301362-f3lp10lm	274	44	virus	virus	NN
cord-301362-f3lp10lm	274	45	-	-	HYPH
cord-301362-f3lp10lm	274	46	induced	induce	VBN
cord-301362-f3lp10lm	274	47	mini	mini	NN
cord-301362-f3lp10lm	274	48	-	-	NN
cord-301362-f3lp10lm	274	49	organelle	organelle	NN
cord-301362-f3lp10lm	274	50	Togaviridae	Togaviridae	NNP
cord-301362-f3lp10lm	274	51	Intracellular	Intracellular	NNP
cord-301362-f3lp10lm	274	52	distribution	distribution	NN
cord-301362-f3lp10lm	274	53	of	of	IN
cord-301362-f3lp10lm	274	54	rubella	rubella	NN
cord-301362-f3lp10lm	274	55	virus	virus	NN
cord-301362-f3lp10lm	274	56	nonstructural	nonstructural	JJ
cord-301362-f3lp10lm	274	57	protein	protein	NN
cord-301362-f3lp10lm	274	58	P150	p150	CD
cord-301362-f3lp10lm	274	59	Biogenesis	biogenesis	NN
cord-301362-f3lp10lm	274	60	of	of	IN
cord-301362-f3lp10lm	274	61	the	the	DT
cord-301362-f3lp10lm	274	62	Semliki	Semliki	NNP
cord-301362-f3lp10lm	274	63	Forest	Forest	NNP
cord-301362-f3lp10lm	274	64	virus	virus	NN
cord-301362-f3lp10lm	274	65	RNA	RNA	NNP
cord-301362-f3lp10lm	274	66	replication	replication	NN
cord-301362-f3lp10lm	274	67	complex	complex	NN
cord-301362-f3lp10lm	275	1	The	the	DT
cord-301362-f3lp10lm	275	2	effects	effect	NNS
cord-301362-f3lp10lm	275	3	of	of	IN
cord-301362-f3lp10lm	275	4	palmitoylation	palmitoylation	NN
cord-301362-f3lp10lm	275	5	on	on	IN
cord-301362-f3lp10lm	275	6	membrane	membrane	NNP
cord-301362-f3lp10lm	275	7	association	association	NNP
cord-301362-f3lp10lm	275	8	of	of	IN
cord-301362-f3lp10lm	275	9	Semliki	Semliki	NNP
cord-301362-f3lp10lm	275	10	forest	forest	NN
cord-301362-f3lp10lm	275	11	virus	virus	NN
cord-301362-f3lp10lm	275	12	RNA	RNA	NNP
cord-301362-f3lp10lm	275	13	capping	cap	VBG
cord-301362-f3lp10lm	275	14	enzyme	enzyme	NN
cord-301362-f3lp10lm	275	15	Membrane	membrane	NN
cord-301362-f3lp10lm	275	16	binding	bind	VBG
cord-301362-f3lp10lm	275	17	mechanism	mechanism	NN
cord-301362-f3lp10lm	275	18	of	of	IN
cord-301362-f3lp10lm	275	19	an	an	DT
cord-301362-f3lp10lm	275	20	RNA	RNA	NNP
cord-301362-f3lp10lm	275	21	virus	virus	NN
cord-301362-f3lp10lm	275	22	-	-	HYPH
cord-301362-f3lp10lm	275	23	capping	cap	VBG
cord-301362-f3lp10lm	275	24	enzyme	enzyme	NN
cord-301362-f3lp10lm	276	1	The	the	DT
cord-301362-f3lp10lm	276	2	TLR3	TLR3	NNP
cord-301362-f3lp10lm	276	3	signaling	signal	VBG
cord-301362-f3lp10lm	276	4	complex	complex	JJ
cord-301362-f3lp10lm	276	5	forms	form	NNS
cord-301362-f3lp10lm	276	6	by	by	IN
cord-301362-f3lp10lm	276	7	cooperative	cooperative	JJ
cord-301362-f3lp10lm	276	8	receptor	receptor	NN
cord-301362-f3lp10lm	276	9	dimerization	dimerization	NN
cord-301362-f3lp10lm	276	10	Structural	structural	JJ
cord-301362-f3lp10lm	276	11	basis	basis	NN
cord-301362-f3lp10lm	276	12	of	of	IN
cord-301362-f3lp10lm	276	13	toll	toll	NN
cord-301362-f3lp10lm	276	14	-	-	HYPH
cord-301362-f3lp10lm	276	15	like	like	JJ
cord-301362-f3lp10lm	276	16	receptor	receptor	NN
cord-301362-f3lp10lm	276	17	3	3	CD
cord-301362-f3lp10lm	276	18	signaling	signal	VBG
cord-301362-f3lp10lm	276	19	with	with	IN
cord-301362-f3lp10lm	276	20	double	double	RB
cord-301362-f3lp10lm	276	21	-	-	HYPH
cord-301362-f3lp10lm	276	22	stranded	strand	VBN
cord-301362-f3lp10lm	276	23	RNA	RNA	NNP
cord-301362-f3lp10lm	276	24	Structural	structural	JJ
cord-301362-f3lp10lm	276	25	insights	insight	NNS
cord-301362-f3lp10lm	276	26	into	into	IN
cord-301362-f3lp10lm	276	27	RNA	RNA	NNP
cord-301362-f3lp10lm	276	28	recognition	recognition	NN
cord-301362-f3lp10lm	276	29	by	by	IN
cord-301362-f3lp10lm	276	30	RIG	rig	NN
cord-301362-f3lp10lm	276	31	-	-	:
cord-301362-f3lp10lm	276	32	I	I	NNP
cord-301362-f3lp10lm	276	33	Lysosomes	Lysosomes	NNP
cord-301362-f3lp10lm	276	34	:	:	:
cord-301362-f3lp10lm	276	35	fusion	fusion	NN
cord-301362-f3lp10lm	276	36	and	and	CC
cord-301362-f3lp10lm	276	37	function	function	VB
cord-301362-f3lp10lm	276	38	Short	short	JJ
cord-301362-f3lp10lm	276	39	double	double	RB
cord-301362-f3lp10lm	276	40	-	-	HYPH
cord-301362-f3lp10lm	276	41	stranded	stranded	JJ
cord-301362-f3lp10lm	276	42	RNAs	rna	NNS
cord-301362-f3lp10lm	276	43	with	with	IN
cord-301362-f3lp10lm	276	44	an	an	DT
cord-301362-f3lp10lm	276	45	overhanging	overhanging	JJ
cord-301362-f3lp10lm	276	46	5	5	CD
cord-301362-f3lp10lm	276	47	'	'	``
cord-301362-f3lp10lm	276	48	ppp	ppp	NN
cord-301362-f3lp10lm	276	49	-	-	HYPH
cord-301362-f3lp10lm	276	50	nucleotide	nucleotide	JJ
cord-301362-f3lp10lm	276	51	,	,	,
cord-301362-f3lp10lm	276	52	as	as	IN
cord-301362-f3lp10lm	276	53	found	find	VBN
cord-301362-f3lp10lm	276	54	in	in	IN
cord-301362-f3lp10lm	276	55	arenavirus	arenavirus	NNP
cord-301362-f3lp10lm	276	56	genomes	genome	NNS
cord-301362-f3lp10lm	276	57	,	,	,
cord-301362-f3lp10lm	276	58	act	act	VBP
cord-301362-f3lp10lm	276	59	as	as	IN
cord-301362-f3lp10lm	276	60	RIG	rig	NN
cord-301362-f3lp10lm	276	61	-	-	:
cord-301362-f3lp10lm	276	62	I	-PRON-	PRP
cord-301362-f3lp10lm	276	63	decoys	decoy	VBZ
cord-301362-f3lp10lm	276	64	Antiviral	antiviral	JJ
cord-301362-f3lp10lm	276	65	responses	response	NNS
cord-301362-f3lp10lm	276	66	induced	induce	VBN
cord-301362-f3lp10lm	276	67	by	by	IN
cord-301362-f3lp10lm	276	68	the	the	DT
cord-301362-f3lp10lm	276	69	TLR3	TLR3	NNP
cord-301362-f3lp10lm	276	70	pathway	pathway	NN
cord-301362-f3lp10lm	276	71	Cellular	cellular	JJ
cord-301362-f3lp10lm	276	72	receptor	receptor	NN
cord-301362-f3lp10lm	276	73	for	for	IN
cord-301362-f3lp10lm	276	74	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	276	75	:	:	:
cord-301362-f3lp10lm	276	76	molecular	molecular	JJ
cord-301362-f3lp10lm	276	77	cloning	cloning	NN
cord-301362-f3lp10lm	276	78	,	,	,
cord-301362-f3lp10lm	276	79	nucleotide	nucleotide	JJ
cord-301362-f3lp10lm	276	80	sequence	sequence	NN
cord-301362-f3lp10lm	276	81	,	,	,
cord-301362-f3lp10lm	276	82	and	and	CC
cord-301362-f3lp10lm	276	83	expression	expression	NN
cord-301362-f3lp10lm	276	84	of	of	IN
cord-301362-f3lp10lm	276	85	a	a	DT
cord-301362-f3lp10lm	276	86	new	new	JJ
cord-301362-f3lp10lm	276	87	member	member	NN
cord-301362-f3lp10lm	276	88	of	of	IN
cord-301362-f3lp10lm	276	89	the	the	DT
cord-301362-f3lp10lm	276	90	immunoglobulin	immunoglobulin	NN
cord-301362-f3lp10lm	276	91	superfamily	superfamily	NN
cord-301362-f3lp10lm	276	92	Molecular	molecular	JJ
cord-301362-f3lp10lm	276	93	evolution	evolution	NN
cord-301362-f3lp10lm	276	94	of	of	IN
cord-301362-f3lp10lm	276	95	vertebrate	vertebrate	JJ
cord-301362-f3lp10lm	276	96	Toll	toll	NN
cord-301362-f3lp10lm	276	97	-	-	HYPH
cord-301362-f3lp10lm	276	98	like	like	JJ
cord-301362-f3lp10lm	276	99	receptors	receptor	NNS
cord-301362-f3lp10lm	276	100	:	:	:
cord-301362-f3lp10lm	276	101	evolutionary	evolutionary	JJ
cord-301362-f3lp10lm	276	102	rate	rate	NN
cord-301362-f3lp10lm	276	103	difference	difference	NN
cord-301362-f3lp10lm	276	104	between	between	IN
cord-301362-f3lp10lm	276	105	their	-PRON-	PRP$
cord-301362-f3lp10lm	276	106	leucine	leucine	NN
cord-301362-f3lp10lm	276	107	-	-	HYPH
cord-301362-f3lp10lm	276	108	rich	rich	JJ
cord-301362-f3lp10lm	276	109	repeats	repeat	NNS
cord-301362-f3lp10lm	276	110	and	and	CC
cord-301362-f3lp10lm	276	111	their	-PRON-	PRP$
cord-301362-f3lp10lm	276	112	TIR	TIR	NNP
cord-301362-f3lp10lm	276	113	domains	domain	NNS
cord-301362-f3lp10lm	276	114	Flock	Flock	NNP
cord-301362-f3lp10lm	276	115	house	house	NN
cord-301362-f3lp10lm	276	116	virus	virus	NN
cord-301362-f3lp10lm	276	117	RNA	RNA	NNP
cord-301362-f3lp10lm	276	118	replicates	replicate	VBZ
cord-301362-f3lp10lm	276	119	on	on	IN
cord-301362-f3lp10lm	276	120	outer	outer	JJ
cord-301362-f3lp10lm	276	121	mitochondrial	mitochondrial	JJ
cord-301362-f3lp10lm	276	122	membranes	membrane	NNS
cord-301362-f3lp10lm	276	123	in	in	IN
cord-301362-f3lp10lm	276	124	Drosophila	Drosophila	NNP
cord-301362-f3lp10lm	276	125	cells	cell	NNS
cord-301362-f3lp10lm	277	1	The	the	DT
cord-301362-f3lp10lm	277	2	non	non	JJ
cord-301362-f3lp10lm	277	3	-	-	JJ
cord-301362-f3lp10lm	277	4	structural	structural	JJ
cord-301362-f3lp10lm	277	5	protein	protein	NN
cord-301362-f3lp10lm	277	6	4A	4a	CD
cord-301362-f3lp10lm	277	7	of	of	IN
cord-301362-f3lp10lm	277	8	dengue	dengue	NN
cord-301362-f3lp10lm	277	9	virus	virus	NN
cord-301362-f3lp10lm	277	10	is	be	VBZ
cord-301362-f3lp10lm	277	11	an	an	DT
cord-301362-f3lp10lm	277	12	integral	integral	JJ
cord-301362-f3lp10lm	277	13	membrane	membrane	NN
cord-301362-f3lp10lm	277	14	protein	protein	NN
cord-301362-f3lp10lm	277	15	inducing	induce	VBG
cord-301362-f3lp10lm	277	16	membrane	membrane	NN
cord-301362-f3lp10lm	277	17	alterations	alteration	NNS
cord-301362-f3lp10lm	277	18	in	in	IN
cord-301362-f3lp10lm	277	19	a	a	DT
cord-301362-f3lp10lm	277	20	2K	2k	RB
cord-301362-f3lp10lm	277	21	-	-	HYPH
cord-301362-f3lp10lm	277	22	regulated	regulate	VBN
cord-301362-f3lp10lm	277	23	manner	manner	NN
cord-301362-f3lp10lm	278	1	Incorporation	incorporation	NN
cord-301362-f3lp10lm	278	2	of	of	IN
cord-301362-f3lp10lm	278	3	lipid	lipid	NN
cord-301362-f3lp10lm	278	4	precursors	precursor	NNS
cord-301362-f3lp10lm	278	5	into	into	IN
cord-301362-f3lp10lm	278	6	cytoplasmic	cytoplasmic	JJ
cord-301362-f3lp10lm	278	7	membranes	membrane	NNS
cord-301362-f3lp10lm	278	8	of	of	IN
cord-301362-f3lp10lm	278	9	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	278	10	-	-	HYPH
cord-301362-f3lp10lm	278	11	infected	infect	VBN
cord-301362-f3lp10lm	278	12	HeLa	HeLa	NNP
cord-301362-f3lp10lm	278	13	cells	cell	NNS
cord-301362-f3lp10lm	278	14	RIG	rig	NN
cord-301362-f3lp10lm	278	15	-	-	:
cord-301362-f3lp10lm	278	16	I	I	NNP
cord-301362-f3lp10lm	278	17	and	and	CC
cord-301362-f3lp10lm	278	18	MDA-5	MDA-5	NNP
cord-301362-f3lp10lm	278	19	detection	detection	NN
cord-301362-f3lp10lm	278	20	of	of	IN
cord-301362-f3lp10lm	278	21	viral	viral	JJ
cord-301362-f3lp10lm	278	22	RNA	RNA	NNP
cord-301362-f3lp10lm	278	23	-	-	HYPH
cord-301362-f3lp10lm	278	24	dependent	dependent	JJ
cord-301362-f3lp10lm	278	25	RNA	RNA	NNP
cord-301362-f3lp10lm	278	26	polymerase	polymerase	NN
cord-301362-f3lp10lm	278	27	activity	activity	NN
cord-301362-f3lp10lm	278	28	restricts	restrict	VBZ
cord-301362-f3lp10lm	278	29	positive	positive	JJ
cord-301362-f3lp10lm	278	30	-	-	HYPH
cord-301362-f3lp10lm	278	31	strand	strand	NN
cord-301362-f3lp10lm	278	32	RNA	RNA	NNP
cord-301362-f3lp10lm	278	33	virus	virus	NN
cord-301362-f3lp10lm	278	34	replication	replication	NN
cord-301362-f3lp10lm	278	35	Antiviral	antiviral	JJ
cord-301362-f3lp10lm	278	36	protection	protection	NN
cord-301362-f3lp10lm	278	37	via	via	IN
cord-301362-f3lp10lm	278	38	RdRPmediated	rdrpmediated	JJ
cord-301362-f3lp10lm	278	39	stable	stable	JJ
cord-301362-f3lp10lm	278	40	activation	activation	NN
cord-301362-f3lp10lm	278	41	of	of	IN
cord-301362-f3lp10lm	278	42	innate	innate	JJ
cord-301362-f3lp10lm	278	43	immunity	immunity	NN
cord-301362-f3lp10lm	278	44	Initiation	initiation	NN
cord-301362-f3lp10lm	278	45	of	of	IN
cord-301362-f3lp10lm	278	46	protein	protein	NN
cord-301362-f3lp10lm	278	47	-	-	HYPH
cord-301362-f3lp10lm	278	48	primed	prime	VBN
cord-301362-f3lp10lm	278	49	picornavirus	picornavirus	NNP
cord-301362-f3lp10lm	278	50	RNA	RNA	NNP
cord-301362-f3lp10lm	278	51	synthesis	synthesis	NN
cord-301362-f3lp10lm	278	52	Architecture	architecture	NN
cord-301362-f3lp10lm	278	53	and	and	CC
cord-301362-f3lp10lm	278	54	biogenesis	biogenesis	NN
cord-301362-f3lp10lm	278	55	of	of	IN
cord-301362-f3lp10lm	278	56	plus	plus	JJ
cord-301362-f3lp10lm	278	57	-	-	HYPH
cord-301362-f3lp10lm	278	58	strand	strand	NN
cord-301362-f3lp10lm	278	59	RNA	RNA	NNP
cord-301362-f3lp10lm	278	60	virus	virus	NN
cord-301362-f3lp10lm	278	61	replication	replication	NN
cord-301362-f3lp10lm	278	62	factories	factory	NNS
cord-301362-f3lp10lm	278	63	Cooperative	Cooperative	NNP
cord-301362-f3lp10lm	278	64	assembly	assembly	NN
cord-301362-f3lp10lm	278	65	and	and	CC
cord-301362-f3lp10lm	278	66	dynamic	dynamic	JJ
cord-301362-f3lp10lm	278	67	disassembly	disassembly	NN
cord-301362-f3lp10lm	278	68	of	of	IN
cord-301362-f3lp10lm	278	69	MDA5	mda5	JJ
cord-301362-f3lp10lm	278	70	filaments	filament	NNS
cord-301362-f3lp10lm	278	71	for	for	IN
cord-301362-f3lp10lm	278	72	viral	viral	JJ
cord-301362-f3lp10lm	278	73	dsRNA	dsrna	NN
cord-301362-f3lp10lm	278	74	recognition	recognition	NNP
cord-301362-f3lp10lm	278	75	RIG	RIG	NNP
cord-301362-f3lp10lm	278	76	-	-	:
cord-301362-f3lp10lm	278	77	I	-PRON-	PRP
cord-301362-f3lp10lm	278	78	forms	form	VBZ
cord-301362-f3lp10lm	278	79	signalingcompetent	signalingcompetent	NN
cord-301362-f3lp10lm	278	80	filaments	filament	NNS
cord-301362-f3lp10lm	278	81	in	in	IN
cord-301362-f3lp10lm	278	82	an	an	DT
cord-301362-f3lp10lm	278	83	ATP	ATP	NNP
cord-301362-f3lp10lm	278	84	-	-	HYPH
cord-301362-f3lp10lm	278	85	dependent	dependent	JJ
cord-301362-f3lp10lm	278	86	,	,	,
cord-301362-f3lp10lm	278	87	ubiquitin	ubiquitin	JJ
cord-301362-f3lp10lm	278	88	-	-	HYPH
cord-301362-f3lp10lm	278	89	independent	independent	JJ
cord-301362-f3lp10lm	278	90	manner	manner	NN
cord-301362-f3lp10lm	279	1	The	the	DT
cord-301362-f3lp10lm	279	2	alphavirus	alphavirus	NNP
cord-301362-f3lp10lm	279	3	replicase	replicase	NN
cord-301362-f3lp10lm	279	4	protein	protein	NN
cord-301362-f3lp10lm	279	5	nsP1	nsP1	NNP
cord-301362-f3lp10lm	279	6	is	be	VBZ
cord-301362-f3lp10lm	279	7	membrane	membrane	NN
cord-301362-f3lp10lm	279	8	-	-	HYPH
cord-301362-f3lp10lm	279	9	associated	associate	VBN
cord-301362-f3lp10lm	279	10	and	and	CC
cord-301362-f3lp10lm	279	11	has	have	VBZ
cord-301362-f3lp10lm	279	12	affinity	affinity	NN
cord-301362-f3lp10lm	279	13	to	to	IN
cord-301362-f3lp10lm	279	14	endocytic	endocytic	JJ
cord-301362-f3lp10lm	279	15	organelles	organelle	NNS
cord-301362-f3lp10lm	279	16	RIG	rig	NN
cord-301362-f3lp10lm	279	17	-	-	HYPH
cord-301362-f3lp10lm	279	18	I	i	NN
cord-301362-f3lp10lm	279	19	-	-	HYPH
cord-301362-f3lp10lm	279	20	mediated	mediate	VBN
cord-301362-f3lp10lm	279	21	antiviral	antiviral	JJ
cord-301362-f3lp10lm	279	22	responses	response	NNS
cord-301362-f3lp10lm	279	23	to	to	IN
cord-301362-f3lp10lm	279	24	single	single	RB
cord-301362-f3lp10lm	279	25	-	-	HYPH
cord-301362-f3lp10lm	279	26	stranded	strand	VBN
cord-301362-f3lp10lm	279	27	RNA	RNA	NNP
cord-301362-f3lp10lm	279	28	bearing	bear	VBG
cord-301362-f3lp10lm	279	29	5'-phosphates	5'-phosphates	CD
cord-301362-f3lp10lm	279	30	Cell	cell	NN
cord-301362-f3lp10lm	279	31	-	-	HYPH
cord-301362-f3lp10lm	279	32	to	to	IN
cord-301362-f3lp10lm	279	33	-	-	HYPH
cord-301362-f3lp10lm	279	34	cell	cell	NN
cord-301362-f3lp10lm	279	35	spread	spread	NN
cord-301362-f3lp10lm	279	36	of	of	IN
cord-301362-f3lp10lm	279	37	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	279	38	in	in	IN
cord-301362-f3lp10lm	279	39	the	the	DT
cord-301362-f3lp10lm	279	40	spinal	spinal	JJ
cord-301362-f3lp10lm	279	41	cord	cord	NN
cord-301362-f3lp10lm	279	42	of	of	IN
cord-301362-f3lp10lm	279	43	bonnet	bonnet	NN
cord-301362-f3lp10lm	279	44	monkeys	monkey	NNS
cord-301362-f3lp10lm	279	45	(	(	-LRB-
cord-301362-f3lp10lm	279	46	Macaca	Macaca	NNP
cord-301362-f3lp10lm	279	47	radiata	radiata	NN
cord-301362-f3lp10lm	279	48	)	)	-RRB-
cord-301362-f3lp10lm	280	1	Picornaviridae	Picornaviridae	NNP
cord-301362-f3lp10lm	280	2	:	:	:
cord-301362-f3lp10lm	280	3	the	the	DT
cord-301362-f3lp10lm	280	4	viruses	virus	NNS
cord-301362-f3lp10lm	280	5	and	and	CC
cord-301362-f3lp10lm	280	6	their	-PRON-	PRP$
cord-301362-f3lp10lm	280	7	replication	replication	NN
cord-301362-f3lp10lm	281	1	Coronaviruses	coronaviruse	NNS
cord-301362-f3lp10lm	281	2	Hijack	hijack	VBP
cord-301362-f3lp10lm	281	3	the	the	DT
cord-301362-f3lp10lm	281	4	LC3-I	lc3-i	NN
cord-301362-f3lp10lm	281	5	-	-	HYPH
cord-301362-f3lp10lm	281	6	positive	positive	JJ
cord-301362-f3lp10lm	281	7	EDEMosomes	edemosome	NNS
cord-301362-f3lp10lm	281	8	,	,	,
cord-301362-f3lp10lm	281	9	ERderived	erderived	JJ
cord-301362-f3lp10lm	281	10	vesicles	vesicle	NNS
cord-301362-f3lp10lm	281	11	exporting	export	VBG
cord-301362-f3lp10lm	281	12	short	short	RB
cord-301362-f3lp10lm	281	13	-	-	HYPH
cord-301362-f3lp10lm	281	14	lived	live	VBN
cord-301362-f3lp10lm	281	15	ERAD	ERAD	NNP
cord-301362-f3lp10lm	281	16	regulators	regulator	NNS
cord-301362-f3lp10lm	281	17	,	,	,
cord-301362-f3lp10lm	281	18	for	for	IN
cord-301362-f3lp10lm	281	19	replication	replication	NN
cord-301362-f3lp10lm	281	20	Intracellular	Intracellular	NNP
cord-301362-f3lp10lm	281	21	vesicle	vesicle	NN
cord-301362-f3lp10lm	281	22	acidification	acidification	NN
cord-301362-f3lp10lm	281	23	promotes	promote	VBZ
cord-301362-f3lp10lm	281	24	maturation	maturation	NN
cord-301362-f3lp10lm	281	25	of	of	IN
cord-301362-f3lp10lm	281	26	infectious	infectious	JJ
cord-301362-f3lp10lm	281	27	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	281	28	particles	particle	NNS
cord-301362-f3lp10lm	281	29	Generation	generation	NN
cord-301362-f3lp10lm	281	30	of	of	IN
cord-301362-f3lp10lm	281	31	unique	unique	JJ
cord-301362-f3lp10lm	281	32	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	281	33	RNA	RNA	NNP
cord-301362-f3lp10lm	281	34	replication	replication	NN
cord-301362-f3lp10lm	281	35	organelles	organelle	NNS
cord-301362-f3lp10lm	282	1	The	the	DT
cord-301362-f3lp10lm	282	2	role	role	NN
cord-301362-f3lp10lm	282	3	of	of	IN
cord-301362-f3lp10lm	282	4	electron	electron	NN
cord-301362-f3lp10lm	282	5	microscopy	microscopy	NN
cord-301362-f3lp10lm	282	6	in	in	IN
cord-301362-f3lp10lm	282	7	studying	study	VBG
cord-301362-f3lp10lm	282	8	the	the	DT
cord-301362-f3lp10lm	282	9	continuum	continuum	NN
cord-301362-f3lp10lm	282	10	of	of	IN
cord-301362-f3lp10lm	282	11	changes	change	NNS
cord-301362-f3lp10lm	282	12	in	in	IN
cord-301362-f3lp10lm	282	13	membranous	membranous	JJ
cord-301362-f3lp10lm	282	14	structures	structure	NNS
cord-301362-f3lp10lm	282	15	during	during	IN
cord-301362-f3lp10lm	282	16	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	282	17	infection	infection	NN
cord-301362-f3lp10lm	282	18	Regulation	regulation	NN
cord-301362-f3lp10lm	282	19	of	of	IN
cord-301362-f3lp10lm	282	20	innate	innate	JJ
cord-301362-f3lp10lm	282	21	antiviral	antiviral	JJ
cord-301362-f3lp10lm	282	22	defenses	defense	NNS
cord-301362-f3lp10lm	282	23	through	through	IN
cord-301362-f3lp10lm	282	24	a	a	DT
cord-301362-f3lp10lm	282	25	shared	share	VBN
cord-301362-f3lp10lm	282	26	repressor	repressor	NN
cord-301362-f3lp10lm	282	27	domain	domain	NN
cord-301362-f3lp10lm	282	28	in	in	IN
cord-301362-f3lp10lm	282	29	RIG	rig	NN
cord-301362-f3lp10lm	282	30	-	-	:
cord-301362-f3lp10lm	282	31	I	I	NNP
cord-301362-f3lp10lm	282	32	and	and	CC
cord-301362-f3lp10lm	282	33	LGP2	LGP2	NNP
cord-301362-f3lp10lm	282	34	Properly	properly	RB
cord-301362-f3lp10lm	282	35	folded	fold	VBD
cord-301362-f3lp10lm	282	36	nonstructural	nonstructural	JJ
cord-301362-f3lp10lm	282	37	polyprotein	polyprotein	NNP
cord-301362-f3lp10lm	282	38	directs	direct	VBZ
cord-301362-f3lp10lm	282	39	the	the	DT
cord-301362-f3lp10lm	282	40	semliki	semliki	NNP
cord-301362-f3lp10lm	282	41	forest	forest	NNP
cord-301362-f3lp10lm	282	42	virus	virus	NN
cord-301362-f3lp10lm	282	43	replication	replication	NN
cord-301362-f3lp10lm	282	44	complex	complex	JJ
cord-301362-f3lp10lm	282	45	to	to	IN
cord-301362-f3lp10lm	282	46	the	the	DT
cord-301362-f3lp10lm	282	47	endosomal	endosomal	NNP
cord-301362-f3lp10lm	282	48	compartment	compartment	NN
cord-301362-f3lp10lm	283	1	Two	two	CD
cord-301362-f3lp10lm	283	2	tyrosine	tyrosine	NN
cord-301362-f3lp10lm	283	3	residues	residue	NNS
cord-301362-f3lp10lm	283	4	of	of	IN
cord-301362-f3lp10lm	283	5	Toll	Toll	NNP
cord-301362-f3lp10lm	283	6	-	-	HYPH
cord-301362-f3lp10lm	283	7	like	like	JJ
cord-301362-f3lp10lm	283	8	receptor	receptor	NN
cord-301362-f3lp10lm	283	9	3	3	CD
cord-301362-f3lp10lm	283	10	trigger	trigger	NN
cord-301362-f3lp10lm	283	11	different	different	JJ
cord-301362-f3lp10lm	283	12	steps	step	NNS
cord-301362-f3lp10lm	283	13	of	of	IN
cord-301362-f3lp10lm	283	14	NFkappa	NFkappa	NNP
cord-301362-f3lp10lm	283	15	B	B	NNP
cord-301362-f3lp10lm	283	16	activation	activation	NN
cord-301362-f3lp10lm	283	17	Toll	Toll	NNP
cord-301362-f3lp10lm	283	18	/	/	SYM
cord-301362-f3lp10lm	283	19	IL-1	IL-1	NNP
cord-301362-f3lp10lm	283	20	receptor	receptor	NN
cord-301362-f3lp10lm	283	21	domain	domain	NN
cord-301362-f3lp10lm	283	22	-	-	HYPH
cord-301362-f3lp10lm	283	23	containing	contain	VBG
cord-301362-f3lp10lm	283	24	adaptor	adaptor	NN
cord-301362-f3lp10lm	283	25	inducing	induce	VBG
cord-301362-f3lp10lm	283	26	IFN	IFN	NNP
cord-301362-f3lp10lm	283	27	-	-	HYPH
cord-301362-f3lp10lm	283	28	beta	beta	NN
cord-301362-f3lp10lm	283	29	(	(	-LRB-
cord-301362-f3lp10lm	283	30	TRIF	TRIF	NNP
cord-301362-f3lp10lm	283	31	)	)	-RRB-
cord-301362-f3lp10lm	283	32	associates	associate	NNS
cord-301362-f3lp10lm	283	33	with	with	IN
cord-301362-f3lp10lm	283	34	TNF	TNF	NNP
cord-301362-f3lp10lm	283	35	receptor	receptor	NN
cord-301362-f3lp10lm	283	36	-	-	HYPH
cord-301362-f3lp10lm	283	37	associated	associate	VBN
cord-301362-f3lp10lm	283	38	factor	factor	NN
cord-301362-f3lp10lm	283	39	6	6	CD
cord-301362-f3lp10lm	283	40	and	and	CC
cord-301362-f3lp10lm	283	41	TANK	tank	NN
cord-301362-f3lp10lm	283	42	-	-	HYPH
cord-301362-f3lp10lm	283	43	binding	bind	VBG
cord-301362-f3lp10lm	283	44	kinase	kinase	NN
cord-301362-f3lp10lm	283	45	1	1	CD
cord-301362-f3lp10lm	283	46	,	,	,
cord-301362-f3lp10lm	283	47	and	and	CC
cord-301362-f3lp10lm	283	48	activates	activate	VBZ
cord-301362-f3lp10lm	283	49	two	two	CD
cord-301362-f3lp10lm	283	50	distinct	distinct	JJ
cord-301362-f3lp10lm	283	51	transcription	transcription	NN
cord-301362-f3lp10lm	283	52	factors	factor	NNS
cord-301362-f3lp10lm	283	53	,	,	,
cord-301362-f3lp10lm	283	54	NF	nf	NN
cord-301362-f3lp10lm	283	55	-	-	HYPH
cord-301362-f3lp10lm	283	56	kappa	kappa	NN
cord-301362-f3lp10lm	283	57	B	B	NNP
cord-301362-f3lp10lm	283	58	and	and	CC
cord-301362-f3lp10lm	283	59	IFN	IFN	NNP
cord-301362-f3lp10lm	283	60	-	-	HYPH
cord-301362-f3lp10lm	283	61	regulatory	regulatory	JJ
cord-301362-f3lp10lm	283	62	factor-3	factor-3	NNP
cord-301362-f3lp10lm	283	63	,	,	,
cord-301362-f3lp10lm	283	64	in	in	IN
cord-301362-f3lp10lm	283	65	the	the	DT
cord-301362-f3lp10lm	283	66	Toll	Toll	NNP
cord-301362-f3lp10lm	283	67	-	-	HYPH
cord-301362-f3lp10lm	283	68	like	like	JJ
cord-301362-f3lp10lm	283	69	receptor	receptor	NN
cord-301362-f3lp10lm	283	70	signaling	signal	VBG
cord-301362-f3lp10lm	283	71	Cellular	cellular	JJ
cord-301362-f3lp10lm	283	72	origin	origin	NN
cord-301362-f3lp10lm	283	73	and	and	CC
cord-301362-f3lp10lm	283	74	ultrastructure	ultrastructure	NN
cord-301362-f3lp10lm	283	75	of	of	IN
cord-301362-f3lp10lm	283	76	membranes	membrane	NNS
cord-301362-f3lp10lm	283	77	induced	induce	VBN
cord-301362-f3lp10lm	283	78	during	during	IN
cord-301362-f3lp10lm	283	79	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	283	80	infection	infection	NN
cord-301362-f3lp10lm	283	81	Autophagy	Autophagy	NNP
cord-301362-f3lp10lm	283	82	and	and	CC
cord-301362-f3lp10lm	283	83	human	human	JJ
cord-301362-f3lp10lm	283	84	disease	disease	NN
cord-301362-f3lp10lm	283	85	:	:	:
cord-301362-f3lp10lm	283	86	emerging	emerge	VBG
cord-301362-f3lp10lm	283	87	themes	theme	NNS
cord-301362-f3lp10lm	283	88	Biology	biology	NN
cord-301362-f3lp10lm	283	89	and	and	CC
cord-301362-f3lp10lm	283	90	pathogenesis	pathogenesis	NN
cord-301362-f3lp10lm	283	91	of	of	IN
cord-301362-f3lp10lm	283	92	chikungunya	chikungunya	NN
cord-301362-f3lp10lm	283	93	virus	virus	NN
cord-301362-f3lp10lm	283	94	Interplay	interplay	JJ
cord-301362-f3lp10lm	283	95	between	between	IN
cord-301362-f3lp10lm	283	96	the	the	DT
cord-301362-f3lp10lm	283	97	cellular	cellular	JJ
cord-301362-f3lp10lm	283	98	autophagy	autophagy	NN
cord-301362-f3lp10lm	283	99	machinery	machinery	NN
cord-301362-f3lp10lm	283	100	and	and	CC
cord-301362-f3lp10lm	283	101	positive	positive	JJ
cord-301362-f3lp10lm	283	102	-	-	HYPH
cord-301362-f3lp10lm	283	103	stranded	strand	VBN
cord-301362-f3lp10lm	283	104	RNA	RNA	NNP
cord-301362-f3lp10lm	283	105	viruses	virus	NNS
cord-301362-f3lp10lm	283	106	Role	role	NN
cord-301362-f3lp10lm	283	107	of	of	IN
cord-301362-f3lp10lm	283	108	ribosomes	ribosome	NNS
cord-301362-f3lp10lm	283	109	in	in	IN
cord-301362-f3lp10lm	283	110	Semliki	Semliki	NNP
cord-301362-f3lp10lm	283	111	Forest	Forest	NNP
cord-301362-f3lp10lm	283	112	virus	virus	NN
cord-301362-f3lp10lm	283	113	nucleocapsid	nucleocapsid	NN
cord-301362-f3lp10lm	284	1	uncoating	uncoate	VBG
cord-301362-f3lp10lm	284	2	Replication	Replication	NNP
cord-301362-f3lp10lm	284	3	of	of	IN
cord-301362-f3lp10lm	284	4	hepatitis	hepatitis	NN
cord-301362-f3lp10lm	284	5	C	C	NNP
cord-301362-f3lp10lm	284	6	virus	virus	NN
cord-301362-f3lp10lm	284	7	RNA	RNA	NNP
cord-301362-f3lp10lm	284	8	on	on	IN
cord-301362-f3lp10lm	284	9	autophagosomal	autophagosomal	NNP
cord-301362-f3lp10lm	284	10	membranes	membrane	NNS
cord-301362-f3lp10lm	284	11	Phosphatidylinositol	Phosphatidylinositol	NNP
cord-301362-f3lp10lm	284	12	3-kinase-	3-kinase-	NNP
cord-301362-f3lp10lm	284	13	,	,	,
cord-301362-f3lp10lm	284	14	actin-	actin-	NN
cord-301362-f3lp10lm	284	15	,	,	,
cord-301362-f3lp10lm	284	16	and	and	CC
cord-301362-f3lp10lm	284	17	microtubule	microtubule	NN
cord-301362-f3lp10lm	284	18	-	-	HYPH
cord-301362-f3lp10lm	284	19	dependent	dependent	JJ
cord-301362-f3lp10lm	284	20	transport	transport	NN
cord-301362-f3lp10lm	284	21	of	of	IN
cord-301362-f3lp10lm	284	22	Semliki	Semliki	NNP
cord-301362-f3lp10lm	284	23	Forest	Forest	NNP
cord-301362-f3lp10lm	284	24	Virus	Virus	NNP
cord-301362-f3lp10lm	284	25	replication	replication	NN
cord-301362-f3lp10lm	284	26	complexes	complex	NNS
cord-301362-f3lp10lm	284	27	from	from	IN
cord-301362-f3lp10lm	284	28	the	the	DT
cord-301362-f3lp10lm	284	29	plasma	plasma	NN
cord-301362-f3lp10lm	284	30	membrane	membrane	NN
cord-301362-f3lp10lm	284	31	to	to	IN
cord-301362-f3lp10lm	284	32	modified	modify	VBN
cord-301362-f3lp10lm	284	33	lysosomes	lysosome	NNS
cord-301362-f3lp10lm	284	34	Role	role	NN
cord-301362-f3lp10lm	284	35	of	of	IN
cord-301362-f3lp10lm	284	36	the	the	DT
cord-301362-f3lp10lm	284	37	amphipathic	amphipathic	NNP
cord-301362-f3lp10lm	284	38	peptide	peptide	NNP
cord-301362-f3lp10lm	284	39	of	of	IN
cord-301362-f3lp10lm	284	40	Semliki	Semliki	NNP
cord-301362-f3lp10lm	284	41	forest	forest	NN
cord-301362-f3lp10lm	284	42	virus	virus	NN
cord-301362-f3lp10lm	284	43	replicase	replicase	NNP
cord-301362-f3lp10lm	284	44	protein	protein	NNP
cord-301362-f3lp10lm	284	45	nsP1	nsP1	NNP
cord-301362-f3lp10lm	284	46	in	in	IN
cord-301362-f3lp10lm	284	47	membrane	membrane	NNP
cord-301362-f3lp10lm	284	48	association	association	NNP
cord-301362-f3lp10lm	284	49	and	and	CC
cord-301362-f3lp10lm	284	50	virus	virus	NN
cord-301362-f3lp10lm	284	51	replication	replication	NN
cord-301362-f3lp10lm	284	52	Structure	Structure	NNP
cord-301362-f3lp10lm	284	53	,	,	,
cord-301362-f3lp10lm	284	54	function	function	NN
cord-301362-f3lp10lm	284	55	and	and	CC
cord-301362-f3lp10lm	284	56	evolution	evolution	NN
cord-301362-f3lp10lm	284	57	of	of	IN
cord-301362-f3lp10lm	284	58	picornaviruses	picornavirus	NNS
cord-301362-f3lp10lm	284	59	Remodeling	remodel	VBG
cord-301362-f3lp10lm	284	60	the	the	DT
cord-301362-f3lp10lm	284	61	endoplasmic	endoplasmic	NN
cord-301362-f3lp10lm	284	62	reticulum	reticulum	NN
cord-301362-f3lp10lm	284	63	by	by	IN
cord-301362-f3lp10lm	284	64	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	284	65	infection	infection	NN
cord-301362-f3lp10lm	284	66	and	and	CC
cord-301362-f3lp10lm	284	67	by	by	IN
cord-301362-f3lp10lm	284	68	individual	individual	JJ
cord-301362-f3lp10lm	284	69	viral	viral	JJ
cord-301362-f3lp10lm	284	70	proteins	protein	NNS
cord-301362-f3lp10lm	284	71	:	:	:
cord-301362-f3lp10lm	284	72	an	an	DT
cord-301362-f3lp10lm	284	73	autophagy	autophagy	NN
cord-301362-f3lp10lm	284	74	-	-	HYPH
cord-301362-f3lp10lm	284	75	like	like	JJ
cord-301362-f3lp10lm	284	76	origin	origin	NN
cord-301362-f3lp10lm	284	77	for	for	IN
cord-301362-f3lp10lm	284	78	virus	virus	NN
cord-301362-f3lp10lm	284	79	-	-	HYPH
cord-301362-f3lp10lm	284	80	induced	induce	VBN
cord-301362-f3lp10lm	284	81	vesicles	vesicle	NNS
cord-301362-f3lp10lm	285	1	LRRC59	LRRC59	NNP
cord-301362-f3lp10lm	285	2	regulates	regulate	VBZ
cord-301362-f3lp10lm	285	3	trafficking	trafficking	NN
cord-301362-f3lp10lm	285	4	of	of	IN
cord-301362-f3lp10lm	285	5	nucleic	nucleic	JJ
cord-301362-f3lp10lm	285	6	acid	acid	NN
cord-301362-f3lp10lm	285	7	-	-	HYPH
cord-301362-f3lp10lm	285	8	sensing	sense	VBG
cord-301362-f3lp10lm	285	9	TLRs	tlr	NNS
cord-301362-f3lp10lm	285	10	from	from	IN
cord-301362-f3lp10lm	285	11	the	the	DT
cord-301362-f3lp10lm	285	12	endoplasmic	endoplasmic	NN
cord-301362-f3lp10lm	285	13	reticulum	reticulum	NN
cord-301362-f3lp10lm	285	14	via	via	IN
cord-301362-f3lp10lm	285	15	association	association	NN
cord-301362-f3lp10lm	285	16	with	with	IN
cord-301362-f3lp10lm	285	17	UNC93B1	UNC93B1	NNP
cord-301362-f3lp10lm	285	18	Pattern	Pattern	NNP
cord-301362-f3lp10lm	285	19	recognition	recognition	NN
cord-301362-f3lp10lm	285	20	receptors	receptor	NNS
cord-301362-f3lp10lm	285	21	and	and	CC
cord-301362-f3lp10lm	285	22	the	the	DT
cord-301362-f3lp10lm	285	23	innate	innate	JJ
cord-301362-f3lp10lm	285	24	immune	immune	JJ
cord-301362-f3lp10lm	285	25	response	response	NN
cord-301362-f3lp10lm	285	26	to	to	IN
cord-301362-f3lp10lm	285	27	viral	viral	JJ
cord-301362-f3lp10lm	285	28	infection	infection	NN
cord-301362-f3lp10lm	286	1	Poliovirus	Poliovirus	NNP
cord-301362-f3lp10lm	286	2	infection	infection	NN
cord-301362-f3lp10lm	286	3	transiently	transiently	RB
cord-301362-f3lp10lm	286	4	increases	increase	VBZ
cord-301362-f3lp10lm	286	5	COPII	COPII	NNP
cord-301362-f3lp10lm	286	6	vesicle	vesicle	NN
cord-301362-f3lp10lm	286	7	budding	bud	VBG
cord-301362-f3lp10lm	286	8	Characterization	characterization	NN
cord-301362-f3lp10lm	286	9	of	of	IN
cord-301362-f3lp10lm	286	10	early	early	JJ
cord-301362-f3lp10lm	286	11	steps	step	NNS
cord-301362-f3lp10lm	286	12	in	in	IN
cord-301362-f3lp10lm	286	13	the	the	DT
cord-301362-f3lp10lm	286	14	poliovirus	poliovirus	NN
cord-301362-f3lp10lm	286	15	infection	infection	NN
cord-301362-f3lp10lm	286	16	process	process	NN
cord-301362-f3lp10lm	286	17	:	:	:
cord-301362-f3lp10lm	286	18	receptordecorated	receptordecorate	VBN
cord-301362-f3lp10lm	286	19	liposomes	liposome	NNS
cord-301362-f3lp10lm	286	20	induce	induce	VBP
cord-301362-f3lp10lm	286	21	conversion	conversion	NN
cord-301362-f3lp10lm	286	22	of	of	IN
cord-301362-f3lp10lm	286	23	the	the	DT
cord-301362-f3lp10lm	286	24	virus	virus	NN
cord-301362-f3lp10lm	286	25	to	to	IN
cord-301362-f3lp10lm	286	26	membrane	membrane	NN
cord-301362-f3lp10lm	286	27	-	-	HYPH
cord-301362-f3lp10lm	286	28	anchored	anchor	VBN
cord-301362-f3lp10lm	286	29	entry	entry	NN
cord-301362-f3lp10lm	286	30	-	-	HYPH
cord-301362-f3lp10lm	286	31	intermediate	intermediate	JJ
cord-301362-f3lp10lm	286	32	particles	particle	NNS
cord-301362-f3lp10lm	286	33	Regulation	regulation	NN
cord-301362-f3lp10lm	286	34	of	of	IN
cord-301362-f3lp10lm	286	35	the	the	DT
cord-301362-f3lp10lm	286	36	sequential	sequential	JJ
cord-301362-f3lp10lm	286	37	processing	processing	NN
cord-301362-f3lp10lm	286	38	of	of	IN
cord-301362-f3lp10lm	286	39	Semliki	Semliki	NNP
cord-301362-f3lp10lm	286	40	Forest	Forest	NNP
cord-301362-f3lp10lm	286	41	virus	virus	NN
cord-301362-f3lp10lm	286	42	replicase	replicase	NNP
cord-301362-f3lp10lm	286	43	polyprotein	polyprotein	NNP
cord-301362-f3lp10lm	286	44	Composition	Composition	NNP
cord-301362-f3lp10lm	286	45	and	and	CC
cord-301362-f3lp10lm	286	46	three	three	CD
cord-301362-f3lp10lm	286	47	-	-	HYPH
cord-301362-f3lp10lm	286	48	dimensional	dimensional	JJ
cord-301362-f3lp10lm	286	49	architecture	architecture	NN
cord-301362-f3lp10lm	286	50	of	of	IN
cord-301362-f3lp10lm	286	51	the	the	DT
cord-301362-f3lp10lm	286	52	dengue	dengue	NN
cord-301362-f3lp10lm	286	53	virus	virus	NN
cord-301362-f3lp10lm	286	54	replication	replication	NN
cord-301362-f3lp10lm	286	55	and	and	CC
cord-301362-f3lp10lm	286	56	assembly	assembly	NN
cord-301362-f3lp10lm	286	57	sites	site	NNS
cord-301362-f3lp10lm	286	58	Structural	structural	JJ
cord-301362-f3lp10lm	286	59	basis	basis	NN
cord-301362-f3lp10lm	286	60	for	for	IN
cord-301362-f3lp10lm	286	61	the	the	DT
cord-301362-f3lp10lm	286	62	prion	prion	NN
cord-301362-f3lp10lm	286	63	-	-	HYPH
cord-301362-f3lp10lm	286	64	like	like	IN
cord-301362-f3lp10lm	286	65	MAVS	MAVS	NNP
cord-301362-f3lp10lm	286	66	filaments	filament	NNS
cord-301362-f3lp10lm	286	67	in	in	IN
cord-301362-f3lp10lm	286	68	antiviral	antiviral	JJ
cord-301362-f3lp10lm	286	69	innate	innate	JJ
cord-301362-f3lp10lm	286	70	immunity	immunity	NN
cord-301362-f3lp10lm	286	71	Shared	share	VBN
cord-301362-f3lp10lm	286	72	and	and	CC
cord-301362-f3lp10lm	286	73	unique	unique	JJ
cord-301362-f3lp10lm	286	74	functions	function	NNS
cord-301362-f3lp10lm	286	75	of	of	IN
cord-301362-f3lp10lm	286	76	the	the	DT
cord-301362-f3lp10lm	286	77	DExD	DExD	NNS
cord-301362-f3lp10lm	286	78	/	/	SYM
cord-301362-f3lp10lm	286	79	H	h	NN
cord-301362-f3lp10lm	286	80	-	-	HYPH
cord-301362-f3lp10lm	286	81	box	box	NN
cord-301362-f3lp10lm	286	82	helicases	helicase	NNS
cord-301362-f3lp10lm	286	83	RIG	rig	NN
cord-301362-f3lp10lm	286	84	-	-	:
cord-301362-f3lp10lm	286	85	I	I	NNP
cord-301362-f3lp10lm	286	86	,	,	,
cord-301362-f3lp10lm	286	87	MDA5	MDA5	NNP
cord-301362-f3lp10lm	286	88	,	,	,
cord-301362-f3lp10lm	286	89	and	and	CC
cord-301362-f3lp10lm	286	90	LGP2	LGP2	NNP
cord-301362-f3lp10lm	286	91	in	in	IN
cord-301362-f3lp10lm	286	92	antiviral	antiviral	JJ
cord-301362-f3lp10lm	286	93	innate	innate	JJ
cord-301362-f3lp10lm	286	94	immunity	immunity	NN
cord-301362-f3lp10lm	287	1	The	the	DT
cord-301362-f3lp10lm	287	2	RNA	RNA	NNP
cord-301362-f3lp10lm	287	3	helicase	helicase	NN
cord-301362-f3lp10lm	287	4	RIG	rig	NN
cord-301362-f3lp10lm	287	5	-	-	:
cord-301362-f3lp10lm	287	6	I	-PRON-	PRP
cord-301362-f3lp10lm	287	7	has	have	VBZ
cord-301362-f3lp10lm	287	8	an	an	DT
cord-301362-f3lp10lm	287	9	essential	essential	JJ
cord-301362-f3lp10lm	287	10	function	function	NN
cord-301362-f3lp10lm	287	11	in	in	IN
cord-301362-f3lp10lm	287	12	doublestranded	doublestranded	NNP
cord-301362-f3lp10lm	287	13	RNA	RNA	NNP
cord-301362-f3lp10lm	287	14	-	-	HYPH
cord-301362-f3lp10lm	287	15	induced	induce	VBN
cord-301362-f3lp10lm	287	16	innate	innate	JJ
cord-301362-f3lp10lm	287	17	antiviral	antiviral	JJ
cord-301362-f3lp10lm	287	18	responses	response	NNS
cord-301362-f3lp10lm	287	19	Hepatic	hepatic	JJ
cord-301362-f3lp10lm	287	20	expression	expression	NN
cord-301362-f3lp10lm	287	21	of	of	IN
cord-301362-f3lp10lm	287	22	HCV	HCV	NNP
cord-301362-f3lp10lm	287	23	RNA	RNA	NNP
cord-301362-f3lp10lm	287	24	-	-	HYPH
cord-301362-f3lp10lm	287	25	dependent	dependent	JJ
cord-301362-f3lp10lm	287	26	RNA	RNA	NNP
cord-301362-f3lp10lm	287	27	polymerase	polymerase	NN
cord-301362-f3lp10lm	287	28	triggers	trigger	VBZ
cord-301362-f3lp10lm	287	29	innate	innate	VBP
cord-301362-f3lp10lm	287	30	immune	immune	JJ
cord-301362-f3lp10lm	287	31	signaling	signaling	NN
cord-301362-f3lp10lm	287	32	and	and	CC
cord-301362-f3lp10lm	287	33	cytokine	cytokine	NN
cord-301362-f3lp10lm	287	34	production	production	NN
cord-301362-f3lp10lm	288	1	The	the	DT
cord-301362-f3lp10lm	288	2	authors	author	NNS
cord-301362-f3lp10lm	288	3	declare	declare	VBP
cord-301362-f3lp10lm	288	4	that	that	IN
cord-301362-f3lp10lm	288	5	the	the	DT
cord-301362-f3lp10lm	288	6	research	research	NN
cord-301362-f3lp10lm	288	7	was	be	VBD
cord-301362-f3lp10lm	288	8	conducted	conduct	VBN
cord-301362-f3lp10lm	288	9	in	in	IN
cord-301362-f3lp10lm	288	10	the	the	DT
cord-301362-f3lp10lm	288	11	absence	absence	NN
cord-301362-f3lp10lm	288	12	of	of	IN
cord-301362-f3lp10lm	288	13	any	any	DT
cord-301362-f3lp10lm	288	14	commercial	commercial	JJ
cord-301362-f3lp10lm	288	15	or	or	CC
cord-301362-f3lp10lm	288	16	financial	financial	JJ
cord-301362-f3lp10lm	288	17	relationships	relationship	NNS
cord-301362-f3lp10lm	288	18	that	that	WDT
cord-301362-f3lp10lm	288	19	could	could	MD
cord-301362-f3lp10lm	288	20	be	be	VB
cord-301362-f3lp10lm	288	21	construed	construe	VBN
cord-301362-f3lp10lm	288	22	as	as	IN
cord-301362-f3lp10lm	288	23	a	a	DT
cord-301362-f3lp10lm	288	24	potential	potential	JJ
cord-301362-f3lp10lm	288	25	conflict	conflict	NN
cord-301362-f3lp10lm	288	26	of	of	IN
cord-301362-f3lp10lm	288	27	interest	interest	NN
cord-301362-f3lp10lm	288	28	.	.	.
cord-301362-f3lp10lm	289	1	Copyright	copyright	NN
cord-301362-f3lp10lm	289	2	©	©	NN
cord-301362-f3lp10lm	289	3	2017	2017	CD
cord-301362-f3lp10lm	289	4	Delgui	Delgui	NNP
cord-301362-f3lp10lm	289	5	and	and	CC
cord-301362-f3lp10lm	289	6	Colombo	Colombo	NNP
cord-301362-f3lp10lm	289	7	.	.	.
cord-301362-f3lp10lm	290	1	This	this	DT
cord-301362-f3lp10lm	290	2	is	be	VBZ
cord-301362-f3lp10lm	290	3	an	an	DT
cord-301362-f3lp10lm	290	4	open	open	JJ
cord-301362-f3lp10lm	290	5	-	-	HYPH
cord-301362-f3lp10lm	290	6	access	access	NN
cord-301362-f3lp10lm	290	7	article	article	NN
cord-301362-f3lp10lm	290	8	distributed	distribute	VBN
cord-301362-f3lp10lm	290	9	under	under	IN
cord-301362-f3lp10lm	290	10	the	the	DT
cord-301362-f3lp10lm	290	11	terms	term	NNS
cord-301362-f3lp10lm	290	12	of	of	IN
cord-301362-f3lp10lm	290	13	the	the	DT
cord-301362-f3lp10lm	290	14	Creative	Creative	NNP
cord-301362-f3lp10lm	290	15	Commons	Commons	NNP
cord-301362-f3lp10lm	290	16	Attribution	Attribution	NNP
cord-301362-f3lp10lm	290	17	License	License	NNP
cord-301362-f3lp10lm	290	18	(	(	-LRB-
cord-301362-f3lp10lm	290	19	CC	CC	NNP
cord-301362-f3lp10lm	290	20	BY	BY	NNP
cord-301362-f3lp10lm	290	21	)	)	-RRB-
cord-301362-f3lp10lm	290	22	.	.	.
cord-301362-f3lp10lm	291	1	The	the	DT
cord-301362-f3lp10lm	291	2	use	use	NN
cord-301362-f3lp10lm	291	3	,	,	,
cord-301362-f3lp10lm	291	4	distribution	distribution	NN
cord-301362-f3lp10lm	291	5	or	or	CC
cord-301362-f3lp10lm	291	6	reproduction	reproduction	NN
cord-301362-f3lp10lm	291	7	in	in	IN
cord-301362-f3lp10lm	291	8	other	other	JJ
cord-301362-f3lp10lm	291	9	forums	forum	NNS
cord-301362-f3lp10lm	291	10	is	be	VBZ
cord-301362-f3lp10lm	291	11	permitted	permit	VBN
cord-301362-f3lp10lm	291	12	,	,	,
cord-301362-f3lp10lm	291	13	provided	provide	VBD
cord-301362-f3lp10lm	291	14	the	the	DT
cord-301362-f3lp10lm	291	15	original	original	JJ
cord-301362-f3lp10lm	291	16	author(s	author(s	NNP
cord-301362-f3lp10lm	291	17	)	)	-RRB-
cord-301362-f3lp10lm	291	18	or	or	CC
cord-301362-f3lp10lm	291	19	licensor	licensor	NN
cord-301362-f3lp10lm	291	20	are	be	VBP
cord-301362-f3lp10lm	291	21	credited	credit	VBN
cord-301362-f3lp10lm	291	22	and	and	CC
cord-301362-f3lp10lm	291	23	that	that	IN
cord-301362-f3lp10lm	291	24	the	the	DT
cord-301362-f3lp10lm	291	25	original	original	JJ
cord-301362-f3lp10lm	291	26	publication	publication	NN
cord-301362-f3lp10lm	291	27	in	in	IN
cord-301362-f3lp10lm	291	28	this	this	DT
cord-301362-f3lp10lm	291	29	journal	journal	NN
cord-301362-f3lp10lm	291	30	is	be	VBZ
cord-301362-f3lp10lm	291	31	cited	cite	VBN
cord-301362-f3lp10lm	291	32	,	,	,
cord-301362-f3lp10lm	291	33	in	in	IN
cord-301362-f3lp10lm	291	34	accordance	accordance	NN
cord-301362-f3lp10lm	291	35	with	with	IN
cord-301362-f3lp10lm	291	36	accepted	accepted	JJ
cord-301362-f3lp10lm	291	37	academic	academic	JJ
cord-301362-f3lp10lm	291	38	practice	practice	NN
cord-301362-f3lp10lm	291	39	.	.	.
cord-301362-f3lp10lm	292	1	No	no	DT
cord-301362-f3lp10lm	292	2	use	use	NN
cord-301362-f3lp10lm	292	3	,	,	,
cord-301362-f3lp10lm	292	4	distribution	distribution	NN
cord-301362-f3lp10lm	292	5	or	or	CC
cord-301362-f3lp10lm	292	6	reproduction	reproduction	NN
cord-301362-f3lp10lm	292	7	is	be	VBZ
cord-301362-f3lp10lm	292	8	permitted	permit	VBN
cord-301362-f3lp10lm	292	9	which	which	WDT
cord-301362-f3lp10lm	292	10	does	do	VBZ
cord-301362-f3lp10lm	292	11	not	not	RB
cord-301362-f3lp10lm	292	12	comply	comply	VB
cord-301362-f3lp10lm	292	13	with	with	IN
cord-301362-f3lp10lm	292	14	these	these	DT
cord-301362-f3lp10lm	292	15	terms	term	NNS
cord-301362-f3lp10lm	292	16	.	.	.