id	sid	tid	token	lemma	pos
cord-305737-bnzd7b25	1	1	key	key	JJ
cord-305737-bnzd7b25	1	2	:	:	:
cord-305737-bnzd7b25	1	3	cord-305737-bnzd7b25	cord-305737-bnzd7b25	NN
cord-305737-bnzd7b25	2	1	authors	author	NNS
cord-305737-bnzd7b25	2	2	:	:	:
cord-305737-bnzd7b25	2	3	Rehwinkel	Rehwinkel	NNP
cord-305737-bnzd7b25	2	4	,	,	,
cord-305737-bnzd7b25	2	5	Jan	Jan	NNP
cord-305737-bnzd7b25	2	6	;	;	:
cord-305737-bnzd7b25	2	7	Reis	Reis	NNP
cord-305737-bnzd7b25	2	8	e	e	NNP
cord-305737-bnzd7b25	2	9	Sousa	Sousa	NNP
cord-305737-bnzd7b25	2	10	,	,	,
cord-305737-bnzd7b25	3	1	Caetano	Caetano	NNP
cord-305737-bnzd7b25	3	2	title	title	NN
cord-305737-bnzd7b25	3	3	:	:	:
cord-305737-bnzd7b25	4	1	Targeting	target	VBG
cord-305737-bnzd7b25	4	2	the	the	DT
cord-305737-bnzd7b25	4	3	viral	viral	JJ
cord-305737-bnzd7b25	4	4	Achilles	Achilles	NNP
cord-305737-bnzd7b25	4	5	’	'	''
cord-305737-bnzd7b25	4	6	heel	heel	NN
cord-305737-bnzd7b25	5	1	:	:	:
cord-305737-bnzd7b25	5	2	recognition	recognition	NN
cord-305737-bnzd7b25	5	3	of	of	IN
cord-305737-bnzd7b25	5	4	5′-triphosphate	5′-triphosphate	CD
cord-305737-bnzd7b25	5	5	RNA	RNA	NNP
cord-305737-bnzd7b25	5	6	in	in	IN
cord-305737-bnzd7b25	5	7	innate	innate	JJ
cord-305737-bnzd7b25	5	8	anti	anti	JJ
cord-305737-bnzd7b25	5	9	-	-	JJ
cord-305737-bnzd7b25	5	10	viral	viral	JJ
cord-305737-bnzd7b25	5	11	defence	defence	NN
cord-305737-bnzd7b25	5	12	date	date	NN
cord-305737-bnzd7b25	5	13	:	:	:
cord-305737-bnzd7b25	5	14	2013	2013	CD
cord-305737-bnzd7b25	5	15	-	-	SYM
cord-305737-bnzd7b25	5	16	05	05	CD
cord-305737-bnzd7b25	5	17	-	-	HYPH
cord-305737-bnzd7b25	5	18	23	23	CD
cord-305737-bnzd7b25	5	19	journal	journal	NN
cord-305737-bnzd7b25	5	20	:	:	:
cord-305737-bnzd7b25	6	1	Curr	Curr	NNP
cord-305737-bnzd7b25	6	2	Opin	Opin	NNP
cord-305737-bnzd7b25	6	3	Microbiol	Microbiol	NNP
cord-305737-bnzd7b25	6	4	DOI	DOI	NNP
cord-305737-bnzd7b25	6	5	:	:	:
cord-305737-bnzd7b25	7	1	10.1016	10.1016	CD
cord-305737-bnzd7b25	7	2	/	/	SYM
cord-305737-bnzd7b25	7	3	j.mib.2013.04.009	j.mib.2013.04.009	NNP
cord-305737-bnzd7b25	7	4	sha	sha	NNP
cord-305737-bnzd7b25	7	5	:	:	:
cord-305737-bnzd7b25	7	6	6b2cdea95cd8c0134c69cc5fb592bb113768dd2f	6b2cdea95cd8c0134c69cc5fb592bb113768dd2f	CD
cord-305737-bnzd7b25	7	7	doc_id	doc_id	CD
cord-305737-bnzd7b25	7	8	:	:	:
cord-305737-bnzd7b25	7	9	305737	305737	CD
cord-305737-bnzd7b25	7	10	cord_uid	cord_uid	NN
cord-305737-bnzd7b25	7	11	:	:	:
cord-305737-bnzd7b25	8	1	bnzd7b25	bnzd7b25	NNP
cord-305737-bnzd7b25	8	2	Some	some	DT
cord-305737-bnzd7b25	8	3	RNA	RNA	NNP
cord-305737-bnzd7b25	8	4	virus	virus	NN
cord-305737-bnzd7b25	8	5	genomes	genome	NNS
cord-305737-bnzd7b25	8	6	bear	bear	VBP
cord-305737-bnzd7b25	8	7	5′-triphosphates	5′-triphosphates	CD
cord-305737-bnzd7b25	8	8	,	,	,
cord-305737-bnzd7b25	8	9	which	which	WDT
cord-305737-bnzd7b25	8	10	can	can	MD
cord-305737-bnzd7b25	8	11	be	be	VB
cord-305737-bnzd7b25	8	12	recognized	recognize	VBN
cord-305737-bnzd7b25	8	13	in	in	IN
cord-305737-bnzd7b25	8	14	the	the	DT
cord-305737-bnzd7b25	8	15	cytoplasm	cytoplasm	NN
cord-305737-bnzd7b25	8	16	of	of	IN
cord-305737-bnzd7b25	8	17	infected	infected	JJ
cord-305737-bnzd7b25	8	18	cells	cell	NNS
cord-305737-bnzd7b25	8	19	by	by	IN
cord-305737-bnzd7b25	8	20	host	host	NN
cord-305737-bnzd7b25	8	21	proteins	protein	NNS
cord-305737-bnzd7b25	8	22	that	that	WDT
cord-305737-bnzd7b25	8	23	mediate	mediate	VBP
cord-305737-bnzd7b25	8	24	anti	anti	JJ
cord-305737-bnzd7b25	8	25	-	-	JJ
cord-305737-bnzd7b25	8	26	viral	viral	JJ
cord-305737-bnzd7b25	8	27	immunity	immunity	NN
cord-305737-bnzd7b25	8	28	.	.	.
cord-305737-bnzd7b25	9	1	Both	both	DT
cord-305737-bnzd7b25	9	2	the	the	DT
cord-305737-bnzd7b25	9	3	innate	innate	JJ
cord-305737-bnzd7b25	9	4	sensor	sensor	NN
cord-305737-bnzd7b25	9	5	RIG	rig	NN
cord-305737-bnzd7b25	9	6	-	-	:
cord-305737-bnzd7b25	9	7	I	I	NNP
cord-305737-bnzd7b25	9	8	and	and	CC
cord-305737-bnzd7b25	9	9	the	the	DT
cord-305737-bnzd7b25	9	10	interferon	interferon	NN
cord-305737-bnzd7b25	9	11	-	-	HYPH
cord-305737-bnzd7b25	9	12	induced	induce	VBN
cord-305737-bnzd7b25	9	13	IFIT	IFIT	NNP
cord-305737-bnzd7b25	9	14	proteins	protein	NNS
cord-305737-bnzd7b25	9	15	bind	bind	VBP
cord-305737-bnzd7b25	9	16	to	to	IN
cord-305737-bnzd7b25	9	17	5′-triphosphate	5′-triphosphate	CD
cord-305737-bnzd7b25	9	18	viral	viral	JJ
cord-305737-bnzd7b25	9	19	RNAs	rna	NNS
cord-305737-bnzd7b25	9	20	.	.	.
cord-305737-bnzd7b25	10	1	RIG	rig	NN
cord-305737-bnzd7b25	10	2	-	-	:
cord-305737-bnzd7b25	10	3	I	-PRON-	PRP
cord-305737-bnzd7b25	10	4	signals	signal	VBZ
cord-305737-bnzd7b25	10	5	for	for	IN
cord-305737-bnzd7b25	10	6	induction	induction	NN
cord-305737-bnzd7b25	10	7	of	of	IN
cord-305737-bnzd7b25	10	8	interferons	interferon	NNS
cord-305737-bnzd7b25	10	9	during	during	IN
cord-305737-bnzd7b25	10	10	RNA	RNA	NNP
cord-305737-bnzd7b25	10	11	virus	virus	NN
cord-305737-bnzd7b25	10	12	infection	infection	NN
cord-305737-bnzd7b25	10	13	while	while	IN
cord-305737-bnzd7b25	10	14	IFITs	ifit	NNS
cord-305737-bnzd7b25	10	15	sequester	sequester	VBP
cord-305737-bnzd7b25	10	16	viral	viral	JJ
cord-305737-bnzd7b25	10	17	RNAs	rna	NNS
cord-305737-bnzd7b25	10	18	to	to	TO
cord-305737-bnzd7b25	10	19	exert	exert	VB
cord-305737-bnzd7b25	10	20	an	an	DT
cord-305737-bnzd7b25	10	21	anti	anti	JJ
cord-305737-bnzd7b25	10	22	-	-	JJ
cord-305737-bnzd7b25	10	23	viral	viral	JJ
cord-305737-bnzd7b25	10	24	effect	effect	NN
cord-305737-bnzd7b25	10	25	.	.	.
cord-305737-bnzd7b25	11	1	Notably	notably	RB
cord-305737-bnzd7b25	11	2	,	,	,
cord-305737-bnzd7b25	11	3	the	the	DT
cord-305737-bnzd7b25	11	4	structures	structure	NNS
cord-305737-bnzd7b25	11	5	of	of	IN
cord-305737-bnzd7b25	11	6	these	these	DT
cord-305737-bnzd7b25	11	7	proteins	protein	NNS
cord-305737-bnzd7b25	11	8	reveal	reveal	VBP
cord-305737-bnzd7b25	11	9	both	both	DT
cord-305737-bnzd7b25	11	10	similarities	similarity	NNS
cord-305737-bnzd7b25	11	11	and	and	CC
cord-305737-bnzd7b25	11	12	differences	difference	NNS
cord-305737-bnzd7b25	11	13	,	,	,
cord-305737-bnzd7b25	11	14	which	which	WDT
cord-305737-bnzd7b25	11	15	are	be	VBP
cord-305737-bnzd7b25	11	16	suggestive	suggestive	JJ
cord-305737-bnzd7b25	11	17	of	of	IN
cord-305737-bnzd7b25	11	18	independent	independent	JJ
cord-305737-bnzd7b25	11	19	evolution	evolution	NN
cord-305737-bnzd7b25	11	20	towards	towards	IN
cord-305737-bnzd7b25	11	21	ligand	ligand	NN
cord-305737-bnzd7b25	11	22	binding	binding	NN
cord-305737-bnzd7b25	11	23	.	.	.
cord-305737-bnzd7b25	12	1	5′-triphosphates	5′-triphosphates	CD
cord-305737-bnzd7b25	12	2	,	,	,
cord-305737-bnzd7b25	12	3	which	which	WDT
cord-305737-bnzd7b25	12	4	are	be	VBP
cord-305737-bnzd7b25	12	5	absent	absent	JJ
cord-305737-bnzd7b25	12	6	from	from	IN
cord-305737-bnzd7b25	12	7	most	most	JJS
cord-305737-bnzd7b25	12	8	RNAs	rna	NNS
cord-305737-bnzd7b25	12	9	in	in	IN
cord-305737-bnzd7b25	12	10	the	the	DT
cord-305737-bnzd7b25	12	11	cytosol	cytosol	NN
cord-305737-bnzd7b25	12	12	of	of	IN
cord-305737-bnzd7b25	12	13	uninfected	uninfected	JJ
cord-305737-bnzd7b25	12	14	cells	cell	NNS
cord-305737-bnzd7b25	12	15	,	,	,
cord-305737-bnzd7b25	12	16	are	be	VBP
cord-305737-bnzd7b25	12	17	thus	thus	RB
cord-305737-bnzd7b25	12	18	a	a	DT
cord-305737-bnzd7b25	12	19	marker	marker	NN
cord-305737-bnzd7b25	12	20	of	of	IN
cord-305737-bnzd7b25	12	21	virus	virus	NN
cord-305737-bnzd7b25	12	22	infection	infection	NN
cord-305737-bnzd7b25	12	23	that	that	WDT
cord-305737-bnzd7b25	12	24	is	be	VBZ
cord-305737-bnzd7b25	12	25	targeted	target	VBN
cord-305737-bnzd7b25	12	26	by	by	IN
cord-305737-bnzd7b25	12	27	the	the	DT
cord-305737-bnzd7b25	12	28	innate	innate	JJ
cord-305737-bnzd7b25	12	29	immune	immune	JJ
cord-305737-bnzd7b25	12	30	system	system	NN
cord-305737-bnzd7b25	12	31	for	for	IN
cord-305737-bnzd7b25	12	32	both	both	DT
cord-305737-bnzd7b25	12	33	induction	induction	NN
cord-305737-bnzd7b25	12	34	and	and	CC
cord-305737-bnzd7b25	12	35	execution	execution	NN
cord-305737-bnzd7b25	12	36	of	of	IN
cord-305737-bnzd7b25	12	37	the	the	DT
cord-305737-bnzd7b25	12	38	anti	anti	JJ
cord-305737-bnzd7b25	12	39	-	-	JJ
cord-305737-bnzd7b25	12	40	viral	viral	JJ
cord-305737-bnzd7b25	12	41	response	response	NN
cord-305737-bnzd7b25	12	42	.	.	.
cord-305737-bnzd7b25	13	1	Targeting	target	VBG
cord-305737-bnzd7b25	13	2	the	the	DT
cord-305737-bnzd7b25	13	3	viral	viral	JJ
cord-305737-bnzd7b25	13	4	Achilles	Achilles	NNP
cord-305737-bnzd7b25	13	5	'	'	POS
cord-305737-bnzd7b25	13	6	heel	heel	NN
cord-305737-bnzd7b25	13	7	:	:	:
cord-305737-bnzd7b25	13	8	recognition	recognition	NN
cord-305737-bnzd7b25	13	9	of	of	IN
cord-305737-bnzd7b25	13	10	5	5	CD
cord-305737-bnzd7b25	13	11	0	0	CD
cord-305737-bnzd7b25	13	12	-triphosphate	-triphosphate	NN
cord-305737-bnzd7b25	13	13	RNA	RNA	NNP
cord-305737-bnzd7b25	13	14	in	in	IN
cord-305737-bnzd7b25	13	15	innate	innate	JJ
cord-305737-bnzd7b25	13	16	anti	anti	JJ
cord-305737-bnzd7b25	13	17	-	-	JJ
cord-305737-bnzd7b25	13	18	viral	viral	JJ
cord-305737-bnzd7b25	13	19	defence	defence	NN
cord-305737-bnzd7b25	13	20	Jan	Jan	NNP
cord-305737-bnzd7b25	13	21	Rehwinkel	Rehwinkel	NNP
cord-305737-bnzd7b25	13	22	1	1	CD
cord-305737-bnzd7b25	13	23	and	and	CC
cord-305737-bnzd7b25	13	24	Caetano	Caetano	NNP
cord-305737-bnzd7b25	13	25	Reis	Reis	NNP
cord-305737-bnzd7b25	13	26	e	e	NN
cord-305737-bnzd7b25	13	27	Sousa	Sousa	NNP
cord-305737-bnzd7b25	13	28	2	2	CD
cord-305737-bnzd7b25	14	1	Some	some	DT
cord-305737-bnzd7b25	14	2	RNA	RNA	NNP
cord-305737-bnzd7b25	14	3	virus	virus	NN
cord-305737-bnzd7b25	14	4	genomes	genome	NNS
cord-305737-bnzd7b25	14	5	bear	bear	VBP
cord-305737-bnzd7b25	14	6	5	5	CD
cord-305737-bnzd7b25	14	7	0	0	CD
cord-305737-bnzd7b25	14	8	-triphosphates	-triphosphate	NNS
cord-305737-bnzd7b25	14	9	,	,	,
cord-305737-bnzd7b25	14	10	which	which	WDT
cord-305737-bnzd7b25	14	11	can	can	MD
cord-305737-bnzd7b25	14	12	be	be	VB
cord-305737-bnzd7b25	14	13	recognized	recognize	VBN
cord-305737-bnzd7b25	14	14	in	in	IN
cord-305737-bnzd7b25	14	15	the	the	DT
cord-305737-bnzd7b25	14	16	cytoplasm	cytoplasm	NN
cord-305737-bnzd7b25	14	17	of	of	IN
cord-305737-bnzd7b25	14	18	infected	infected	JJ
cord-305737-bnzd7b25	14	19	cells	cell	NNS
cord-305737-bnzd7b25	14	20	by	by	IN
cord-305737-bnzd7b25	14	21	host	host	NN
cord-305737-bnzd7b25	14	22	proteins	protein	NNS
cord-305737-bnzd7b25	14	23	that	that	WDT
cord-305737-bnzd7b25	14	24	mediate	mediate	VBP
cord-305737-bnzd7b25	14	25	anti	anti	JJ
cord-305737-bnzd7b25	14	26	-	-	JJ
cord-305737-bnzd7b25	14	27	viral	viral	JJ
cord-305737-bnzd7b25	14	28	immunity	immunity	NN
cord-305737-bnzd7b25	14	29	.	.	.
cord-305737-bnzd7b25	15	1	Both	both	DT
cord-305737-bnzd7b25	15	2	the	the	DT
cord-305737-bnzd7b25	15	3	innate	innate	JJ
cord-305737-bnzd7b25	15	4	sensor	sensor	NN
cord-305737-bnzd7b25	15	5	RIG	rig	NN
cord-305737-bnzd7b25	15	6	-	-	:
cord-305737-bnzd7b25	15	7	I	I	NNP
cord-305737-bnzd7b25	15	8	and	and	CC
cord-305737-bnzd7b25	15	9	the	the	DT
cord-305737-bnzd7b25	15	10	interferon	interferon	NN
cord-305737-bnzd7b25	15	11	-	-	HYPH
cord-305737-bnzd7b25	15	12	induced	induce	VBN
cord-305737-bnzd7b25	15	13	IFIT	IFIT	NNP
cord-305737-bnzd7b25	15	14	proteins	protein	NNS
cord-305737-bnzd7b25	15	15	bind	bind	VBP
cord-305737-bnzd7b25	15	16	to	to	IN
cord-305737-bnzd7b25	15	17	5	5	CD
cord-305737-bnzd7b25	15	18	0	0	CD
cord-305737-bnzd7b25	15	19	-triphosphate	-triphosphate	NN
cord-305737-bnzd7b25	15	20	viral	viral	JJ
cord-305737-bnzd7b25	15	21	RNAs	rna	NNS
cord-305737-bnzd7b25	15	22	.	.	.
cord-305737-bnzd7b25	16	1	RIG	rig	NN
cord-305737-bnzd7b25	16	2	-	-	:
cord-305737-bnzd7b25	16	3	I	-PRON-	PRP
cord-305737-bnzd7b25	16	4	signals	signal	VBZ
cord-305737-bnzd7b25	16	5	for	for	IN
cord-305737-bnzd7b25	16	6	induction	induction	NN
cord-305737-bnzd7b25	16	7	of	of	IN
cord-305737-bnzd7b25	16	8	interferons	interferon	NNS
cord-305737-bnzd7b25	16	9	during	during	IN
cord-305737-bnzd7b25	16	10	RNA	RNA	NNP
cord-305737-bnzd7b25	16	11	virus	virus	NN
cord-305737-bnzd7b25	16	12	infection	infection	NN
cord-305737-bnzd7b25	16	13	while	while	IN
cord-305737-bnzd7b25	16	14	IFITs	ifit	NNS
cord-305737-bnzd7b25	16	15	sequester	sequester	VBP
cord-305737-bnzd7b25	16	16	viral	viral	JJ
cord-305737-bnzd7b25	16	17	RNAs	rna	NNS
cord-305737-bnzd7b25	16	18	to	to	TO
cord-305737-bnzd7b25	16	19	exert	exert	VB
cord-305737-bnzd7b25	16	20	an	an	DT
cord-305737-bnzd7b25	16	21	antiviral	antiviral	JJ
cord-305737-bnzd7b25	16	22	effect	effect	NN
cord-305737-bnzd7b25	16	23	.	.	.
cord-305737-bnzd7b25	17	1	Notably	notably	RB
cord-305737-bnzd7b25	17	2	,	,	,
cord-305737-bnzd7b25	17	3	the	the	DT
cord-305737-bnzd7b25	17	4	structures	structure	NNS
cord-305737-bnzd7b25	17	5	of	of	IN
cord-305737-bnzd7b25	17	6	these	these	DT
cord-305737-bnzd7b25	17	7	proteins	protein	NNS
cord-305737-bnzd7b25	17	8	reveal	reveal	VBP
cord-305737-bnzd7b25	17	9	both	both	DT
cord-305737-bnzd7b25	17	10	similarities	similarity	NNS
cord-305737-bnzd7b25	17	11	and	and	CC
cord-305737-bnzd7b25	17	12	differences	difference	NNS
cord-305737-bnzd7b25	17	13	,	,	,
cord-305737-bnzd7b25	17	14	which	which	WDT
cord-305737-bnzd7b25	17	15	are	be	VBP
cord-305737-bnzd7b25	17	16	suggestive	suggestive	JJ
cord-305737-bnzd7b25	17	17	of	of	IN
cord-305737-bnzd7b25	17	18	independent	independent	JJ
cord-305737-bnzd7b25	17	19	evolution	evolution	NN
cord-305737-bnzd7b25	17	20	towards	towards	IN
cord-305737-bnzd7b25	17	21	ligand	ligand	NN
cord-305737-bnzd7b25	17	22	binding	binding	NN
cord-305737-bnzd7b25	17	23	.	.	.
cord-305737-bnzd7b25	18	1	5	5	LS
cord-305737-bnzd7b25	18	2	0triphosphates	0triphosphates	CD
cord-305737-bnzd7b25	18	3	,	,	,
cord-305737-bnzd7b25	18	4	which	which	WDT
cord-305737-bnzd7b25	18	5	are	be	VBP
cord-305737-bnzd7b25	18	6	absent	absent	JJ
cord-305737-bnzd7b25	18	7	from	from	IN
cord-305737-bnzd7b25	18	8	most	most	JJS
cord-305737-bnzd7b25	18	9	RNAs	rna	NNS
cord-305737-bnzd7b25	18	10	in	in	IN
cord-305737-bnzd7b25	18	11	the	the	DT
cord-305737-bnzd7b25	18	12	cytosol	cytosol	NN
cord-305737-bnzd7b25	18	13	of	of	IN
cord-305737-bnzd7b25	18	14	uninfected	uninfected	JJ
cord-305737-bnzd7b25	18	15	cells	cell	NNS
cord-305737-bnzd7b25	18	16	,	,	,
cord-305737-bnzd7b25	18	17	are	be	VBP
cord-305737-bnzd7b25	18	18	thus	thus	RB
cord-305737-bnzd7b25	18	19	a	a	DT
cord-305737-bnzd7b25	18	20	marker	marker	NN
cord-305737-bnzd7b25	18	21	of	of	IN
cord-305737-bnzd7b25	18	22	virus	virus	NN
cord-305737-bnzd7b25	18	23	infection	infection	NN
cord-305737-bnzd7b25	18	24	that	that	WDT
cord-305737-bnzd7b25	18	25	is	be	VBZ
cord-305737-bnzd7b25	18	26	targeted	target	VBN
cord-305737-bnzd7b25	18	27	by	by	IN
cord-305737-bnzd7b25	18	28	the	the	DT
cord-305737-bnzd7b25	18	29	innate	innate	JJ
cord-305737-bnzd7b25	18	30	immune	immune	JJ
cord-305737-bnzd7b25	18	31	system	system	NN
cord-305737-bnzd7b25	18	32	for	for	IN
cord-305737-bnzd7b25	18	33	both	both	DT
cord-305737-bnzd7b25	18	34	induction	induction	NN
cord-305737-bnzd7b25	18	35	and	and	CC
cord-305737-bnzd7b25	18	36	execution	execution	NN
cord-305737-bnzd7b25	18	37	of	of	IN
cord-305737-bnzd7b25	18	38	the	the	DT
cord-305737-bnzd7b25	18	39	anti	anti	JJ
cord-305737-bnzd7b25	18	40	-	-	JJ
cord-305737-bnzd7b25	18	41	viral	viral	JJ
cord-305737-bnzd7b25	18	42	response	response	NN
cord-305737-bnzd7b25	18	43	.	.	.
cord-305737-bnzd7b25	19	1	The	the	DT
cord-305737-bnzd7b25	19	2	interferon	interferon	NN
cord-305737-bnzd7b25	19	3	system	system	NN
cord-305737-bnzd7b25	19	4	is	be	VBZ
cord-305737-bnzd7b25	19	5	one	one	CD
cord-305737-bnzd7b25	19	6	of	of	IN
cord-305737-bnzd7b25	19	7	the	the	DT
cord-305737-bnzd7b25	19	8	cornerstones	cornerstone	NNS
cord-305737-bnzd7b25	19	9	of	of	IN
cord-305737-bnzd7b25	19	10	innate	innate	JJ
cord-305737-bnzd7b25	19	11	immunity	immunity	NN
cord-305737-bnzd7b25	19	12	in	in	IN
cord-305737-bnzd7b25	19	13	mammals	mammal	NNS
cord-305737-bnzd7b25	19	14	(	(	-LRB-
cord-305737-bnzd7b25	19	15	Figure	figure	NN
cord-305737-bnzd7b25	19	16	1	1	CD
cord-305737-bnzd7b25	19	17	)	)	-RRB-
cord-305737-bnzd7b25	19	18	.	.	.
cord-305737-bnzd7b25	20	1	Interferons	interferon	NNS
cord-305737-bnzd7b25	20	2	were	be	VBD
cord-305737-bnzd7b25	20	3	discovered	discover	VBN
cord-305737-bnzd7b25	20	4	as	as	IN
cord-305737-bnzd7b25	20	5	soluble	soluble	JJ
cord-305737-bnzd7b25	20	6	factors	factor	NNS
cord-305737-bnzd7b25	20	7	secreted	secrete	VBN
cord-305737-bnzd7b25	20	8	by	by	IN
cord-305737-bnzd7b25	20	9	virally	virally	RB
cord-305737-bnzd7b25	20	10	infected	infect	VBN
cord-305737-bnzd7b25	20	11	cells	cell	NNS
cord-305737-bnzd7b25	20	12	that	that	WDT
cord-305737-bnzd7b25	20	13	protected	protect	VBD
cord-305737-bnzd7b25	20	14	uninfected	uninfected	JJ
cord-305737-bnzd7b25	20	15	cells	cell	NNS
cord-305737-bnzd7b25	20	16	from	from	IN
cord-305737-bnzd7b25	20	17	subsequent	subsequent	JJ
cord-305737-bnzd7b25	20	18	viral	viral	JJ
cord-305737-bnzd7b25	20	19	challenge	challenge	NN
cord-305737-bnzd7b25	20	20	[	[	-LRB-
cord-305737-bnzd7b25	20	21	1	1	CD
cord-305737-bnzd7b25	20	22	]	]	-RRB-
cord-305737-bnzd7b25	20	23	.	.	.
cord-305737-bnzd7b25	21	1	The	the	DT
cord-305737-bnzd7b25	21	2	type	type	NN
cord-305737-bnzd7b25	21	3	I	-PRON-	PRP
cord-305737-bnzd7b25	21	4	interferons	interferon	NNS
cord-305737-bnzd7b25	21	5	(	(	-LRB-
cord-305737-bnzd7b25	21	6	referred	refer	VBN
cord-305737-bnzd7b25	21	7	to	to	IN
cord-305737-bnzd7b25	21	8	as	as	IN
cord-305737-bnzd7b25	21	9	IFN	IFN	NNP
cord-305737-bnzd7b25	21	10	in	in	IN
cord-305737-bnzd7b25	21	11	this	this	DT
cord-305737-bnzd7b25	21	12	review	review	NN
cord-305737-bnzd7b25	21	13	)	)	-RRB-
cord-305737-bnzd7b25	21	14	include	include	VBP
cord-305737-bnzd7b25	21	15	interferon	interferon	NN
cord-305737-bnzd7b25	21	16	-	-	HYPH
cord-305737-bnzd7b25	21	17	b	b	NN
cord-305737-bnzd7b25	21	18	and	and	CC
cord-305737-bnzd7b25	21	19	multiple	multiple	NN
cord-305737-bnzd7b25	22	1	interferon	interferon	NN
cord-305737-bnzd7b25	22	2	-	-	:
cord-305737-bnzd7b25	22	3	a	a	DT
cord-305737-bnzd7b25	22	4	subtypes	subtype	NNS
cord-305737-bnzd7b25	22	5	,	,	,
cord-305737-bnzd7b25	22	6	all	all	DT
cord-305737-bnzd7b25	22	7	of	of	IN
cord-305737-bnzd7b25	22	8	which	which	WDT
cord-305737-bnzd7b25	22	9	signal	signal	VBP
cord-305737-bnzd7b25	22	10	through	through	IN
cord-305737-bnzd7b25	22	11	a	a	DT
cord-305737-bnzd7b25	22	12	common	common	JJ
cord-305737-bnzd7b25	22	13	receptor	receptor	NN
cord-305737-bnzd7b25	22	14	IFNAR	IFNAR	NNP
cord-305737-bnzd7b25	22	15	[	[	-LRB-
cord-305737-bnzd7b25	22	16	2	2	CD
cord-305737-bnzd7b25	22	17	]	]	-RRB-
cord-305737-bnzd7b25	22	18	(	(	-LRB-
cord-305737-bnzd7b25	22	19	Figure	figure	NN
cord-305737-bnzd7b25	22	20	1	1	CD
cord-305737-bnzd7b25	22	21	)	)	-RRB-
cord-305737-bnzd7b25	22	22	.	.	.
cord-305737-bnzd7b25	23	1	All	all	DT
cord-305737-bnzd7b25	23	2	nucleated	nucleated	JJ
cord-305737-bnzd7b25	23	3	cells	cell	NNS
cord-305737-bnzd7b25	23	4	can	can	MD
cord-305737-bnzd7b25	23	5	produce	produce	VB
cord-305737-bnzd7b25	23	6	IFN	IFN	NNP
cord-305737-bnzd7b25	23	7	in	in	IN
cord-305737-bnzd7b25	23	8	response	response	NN
cord-305737-bnzd7b25	23	9	to	to	IN
cord-305737-bnzd7b25	23	10	nucleic	nucleic	JJ
cord-305737-bnzd7b25	23	11	acids	acid	NNS
cord-305737-bnzd7b25	23	12	generated	generate	VBN
cord-305737-bnzd7b25	23	13	during	during	IN
cord-305737-bnzd7b25	23	14	virus	virus	NN
cord-305737-bnzd7b25	23	15	infection	infection	NN
cord-305737-bnzd7b25	23	16	.	.	.
cord-305737-bnzd7b25	24	1	Detection	detection	NN
cord-305737-bnzd7b25	24	2	of	of	IN
cord-305737-bnzd7b25	24	3	these	these	DT
cord-305737-bnzd7b25	24	4	nucleic	nucleic	JJ
cord-305737-bnzd7b25	24	5	acids	acid	NNS
cord-305737-bnzd7b25	24	6	is	be	VBZ
cord-305737-bnzd7b25	24	7	carried	carry	VBN
cord-305737-bnzd7b25	24	8	out	out	RP
cord-305737-bnzd7b25	24	9	within	within	IN
cord-305737-bnzd7b25	24	10	the	the	DT
cord-305737-bnzd7b25	24	11	infected	infected	JJ
cord-305737-bnzd7b25	24	12	cell	cell	NN
cord-305737-bnzd7b25	24	13	by	by	IN
cord-305737-bnzd7b25	24	14	host	host	NN
cord-305737-bnzd7b25	24	15	proteins	protein	NNS
cord-305737-bnzd7b25	24	16	residing	reside	VBG
cord-305737-bnzd7b25	24	17	in	in	IN
cord-305737-bnzd7b25	24	18	the	the	DT
cord-305737-bnzd7b25	24	19	cytosol	cytosol	NN
cord-305737-bnzd7b25	24	20	,	,	,
cord-305737-bnzd7b25	24	21	such	such	JJ
cord-305737-bnzd7b25	24	22	as	as	IN
cord-305737-bnzd7b25	24	23	RIG	rig	NN
cord-305737-bnzd7b25	24	24	-	-	HYPH
cord-305737-bnzd7b25	24	25	I	i	NN
cord-305737-bnzd7b25	24	26	-	-	HYPH
cord-305737-bnzd7b25	24	27	like	like	JJ
cord-305737-bnzd7b25	24	28	receptors	receptor	NNS
cord-305737-bnzd7b25	24	29	(	(	-LRB-
cord-305737-bnzd7b25	24	30	RLRs	RLRs	NNP
cord-305737-bnzd7b25	24	31	)	)	-RRB-
cord-305737-bnzd7b25	24	32	and	and	CC
cord-305737-bnzd7b25	24	33	other	other	JJ
cord-305737-bnzd7b25	24	34	virus	virus	NN
cord-305737-bnzd7b25	24	35	-	-	HYPH
cord-305737-bnzd7b25	24	36	sensing	sense	VBG
cord-305737-bnzd7b25	24	37	receptors	receptor	NNS
cord-305737-bnzd7b25	24	38	[	[	-LRB-
cord-305737-bnzd7b25	24	39	3	3	CD
cord-305737-bnzd7b25	24	40	]	]	-RRB-
cord-305737-bnzd7b25	25	1	(	(	-LRB-
cord-305737-bnzd7b25	25	2	Figure	figure	NN
cord-305737-bnzd7b25	25	3	1	1	CD
cord-305737-bnzd7b25	25	4	)	)	-RRB-
cord-305737-bnzd7b25	25	5	.	.	.
cord-305737-bnzd7b25	26	1	In	in	IN
cord-305737-bnzd7b25	26	2	addition	addition	NN
cord-305737-bnzd7b25	26	3	,	,	,
cord-305737-bnzd7b25	26	4	some	some	DT
cord-305737-bnzd7b25	26	5	cells	cell	NNS
cord-305737-bnzd7b25	26	6	possess	possess	VBP
cord-305737-bnzd7b25	26	7	the	the	DT
cord-305737-bnzd7b25	26	8	ability	ability	NN
cord-305737-bnzd7b25	26	9	to	to	TO
cord-305737-bnzd7b25	26	10	detect	detect	VB
cord-305737-bnzd7b25	26	11	viruses	virus	NNS
cord-305737-bnzd7b25	26	12	in	in	IN
cord-305737-bnzd7b25	26	13	the	the	DT
cord-305737-bnzd7b25	26	14	extracellular	extracellular	JJ
cord-305737-bnzd7b25	26	15	milieu	milieu	NN
cord-305737-bnzd7b25	26	16	using	use	VBG
cord-305737-bnzd7b25	26	17	members	member	NNS
cord-305737-bnzd7b25	26	18	of	of	IN
cord-305737-bnzd7b25	26	19	the	the	DT
cord-305737-bnzd7b25	26	20	toll	toll	NN
cord-305737-bnzd7b25	26	21	-	-	HYPH
cord-305737-bnzd7b25	26	22	like	like	JJ
cord-305737-bnzd7b25	26	23	receptor	receptor	NN
cord-305737-bnzd7b25	26	24	(	(	-LRB-
cord-305737-bnzd7b25	26	25	TLR	TLR	NNP
cord-305737-bnzd7b25	26	26	)	)	-RRB-
cord-305737-bnzd7b25	26	27	family	family	NN
cord-305737-bnzd7b25	26	28	.	.	.
cord-305737-bnzd7b25	27	1	This	this	DT
cord-305737-bnzd7b25	27	2	generally	generally	RB
cord-305737-bnzd7b25	27	3	involves	involve	VBZ
cord-305737-bnzd7b25	27	4	endocytic	endocytic	JJ
cord-305737-bnzd7b25	27	5	uptake	uptake	NN
cord-305737-bnzd7b25	27	6	of	of	IN
cord-305737-bnzd7b25	27	7	viruses	virus	NNS
cord-305737-bnzd7b25	27	8	or	or	CC
cord-305737-bnzd7b25	27	9	remnants	remnant	NNS
cord-305737-bnzd7b25	27	10	of	of	IN
cord-305737-bnzd7b25	27	11	virally	virally	RB
cord-305737-bnzd7b25	27	12	infected	infect	VBN
cord-305737-bnzd7b25	27	13	cells	cell	NNS
cord-305737-bnzd7b25	27	14	into	into	IN
cord-305737-bnzd7b25	27	15	vesicular	vesicular	JJ
cord-305737-bnzd7b25	27	16	compartments	compartment	NNS
cord-305737-bnzd7b25	27	17	surveyed	survey	VBN
cord-305737-bnzd7b25	27	18	by	by	IN
cord-305737-bnzd7b25	27	19	TLR3	TLR3	NNP
cord-305737-bnzd7b25	27	20	,	,	,
cord-305737-bnzd7b25	27	21	7	7	CD
cord-305737-bnzd7b25	27	22	,	,	,
cord-305737-bnzd7b25	27	23	8	8	CD
cord-305737-bnzd7b25	27	24	and	and	CC
cord-305737-bnzd7b25	27	25	9	9	CD
cord-305737-bnzd7b25	27	26	,	,	,
cord-305737-bnzd7b25	27	27	all	all	DT
cord-305737-bnzd7b25	27	28	of	of	IN
cord-305737-bnzd7b25	27	29	which	which	WDT
cord-305737-bnzd7b25	27	30	bind	bind	VBP
cord-305737-bnzd7b25	27	31	nucleic	nucleic	JJ
cord-305737-bnzd7b25	27	32	acids	acid	NNS
cord-305737-bnzd7b25	27	33	(	(	-LRB-
cord-305737-bnzd7b25	27	34	Figure	figure	NN
cord-305737-bnzd7b25	27	35	1	1	CD
cord-305737-bnzd7b25	27	36	)	)	-RRB-
cord-305737-bnzd7b25	27	37	.	.	.
cord-305737-bnzd7b25	28	1	Either	either	CC
cord-305737-bnzd7b25	28	2	RLR	RLR	NNP
cord-305737-bnzd7b25	28	3	or	or	CC
cord-305737-bnzd7b25	28	4	TLR	TLR	NNP
cord-305737-bnzd7b25	28	5	signalling	signal	VBG
cord-305737-bnzd7b25	28	6	then	then	RB
cord-305737-bnzd7b25	28	7	induces	induce	VBZ
cord-305737-bnzd7b25	28	8	expression	expression	NN
cord-305737-bnzd7b25	28	9	of	of	IN
cord-305737-bnzd7b25	28	10	the	the	DT
cord-305737-bnzd7b25	28	11	IFN	IFN	NNP
cord-305737-bnzd7b25	28	12	genes	gene	NNS
cord-305737-bnzd7b25	28	13	(	(	-LRB-
cord-305737-bnzd7b25	28	14	Figure	figure	NN
cord-305737-bnzd7b25	28	15	1	1	CD
cord-305737-bnzd7b25	28	16	)	)	-RRB-
cord-305737-bnzd7b25	28	17	.	.	.
cord-305737-bnzd7b25	29	1	Given	give	VBN
cord-305737-bnzd7b25	29	2	the	the	DT
cord-305737-bnzd7b25	29	3	abundance	abundance	NN
cord-305737-bnzd7b25	29	4	of	of	IN
cord-305737-bnzd7b25	29	5	nucleic	nucleic	JJ
cord-305737-bnzd7b25	29	6	acids	acid	NNS
cord-305737-bnzd7b25	29	7	in	in	IN
cord-305737-bnzd7b25	29	8	uninfected	uninfected	JJ
cord-305737-bnzd7b25	29	9	healthy	healthy	JJ
cord-305737-bnzd7b25	29	10	cells	cell	NNS
cord-305737-bnzd7b25	29	11	and	and	CC
cord-305737-bnzd7b25	29	12	the	the	DT
cord-305737-bnzd7b25	29	13	potential	potential	NN
cord-305737-bnzd7b25	29	14	of	of	IN
cord-305737-bnzd7b25	29	15	IFN	IFN	NNP
cord-305737-bnzd7b25	29	16	to	to	TO
cord-305737-bnzd7b25	29	17	contribute	contribute	VB
cord-305737-bnzd7b25	29	18	to	to	IN
cord-305737-bnzd7b25	29	19	autoinflammatory	autoinflammatory	JJ
cord-305737-bnzd7b25	29	20	and	and	CC
cord-305737-bnzd7b25	29	21	autoimmune	autoimmune	JJ
cord-305737-bnzd7b25	29	22	diseases	disease	NNS
cord-305737-bnzd7b25	29	23	[	[	-LRB-
cord-305737-bnzd7b25	29	24	4	4	CD
cord-305737-bnzd7b25	29	25	]	]	-RRB-
cord-305737-bnzd7b25	29	26	,	,	,
cord-305737-bnzd7b25	29	27	it	-PRON-	PRP
cord-305737-bnzd7b25	29	28	is	be	VBZ
cord-305737-bnzd7b25	29	29	not	not	RB
cord-305737-bnzd7b25	29	30	surprising	surprising	JJ
cord-305737-bnzd7b25	29	31	that	that	IN
cord-305737-bnzd7b25	29	32	sophisticated	sophisticated	JJ
cord-305737-bnzd7b25	29	33	mechanisms	mechanism	NNS
cord-305737-bnzd7b25	29	34	ensure	ensure	VBP
cord-305737-bnzd7b25	29	35	that	that	IN
cord-305737-bnzd7b25	29	36	activation	activation	NN
cord-305737-bnzd7b25	29	37	of	of	IN
cord-305737-bnzd7b25	29	38	RLRs	rlr	NNS
cord-305737-bnzd7b25	29	39	and	and	CC
cord-305737-bnzd7b25	29	40	TLRs	TLRs	NNP
cord-305737-bnzd7b25	29	41	occurs	occur	VBZ
cord-305737-bnzd7b25	29	42	only	only	RB
cord-305737-bnzd7b25	29	43	during	during	IN
cord-305737-bnzd7b25	29	44	infection	infection	NN
cord-305737-bnzd7b25	29	45	.	.	.
cord-305737-bnzd7b25	30	1	One	one	CD
cord-305737-bnzd7b25	30	2	of	of	IN
cord-305737-bnzd7b25	30	3	these	these	DT
cord-305737-bnzd7b25	30	4	mechanisms	mechanism	NNS
cord-305737-bnzd7b25	30	5	is	be	VBZ
cord-305737-bnzd7b25	30	6	the	the	DT
cord-305737-bnzd7b25	30	7	recognition	recognition	NN
cord-305737-bnzd7b25	30	8	of	of	IN
cord-305737-bnzd7b25	30	9	viral	viral	JJ
cord-305737-bnzd7b25	30	10	RNA	RNA	NNP
cord-305737-bnzd7b25	30	11	genomes	genome	NNS
cord-305737-bnzd7b25	30	12	bearing	bear	VBG
cord-305737-bnzd7b25	30	13	a	a	DT
cord-305737-bnzd7b25	30	14	5	5	CD
cord-305737-bnzd7b25	30	15	0	0	CD
cord-305737-bnzd7b25	30	16	-triphosphate	-triphosphate	NN
cord-305737-bnzd7b25	30	17	(	(	-LRB-
cord-305737-bnzd7b25	30	18	5PPP	5ppp	LS
cord-305737-bnzd7b25	30	19	)	)	-RRB-
cord-305737-bnzd7b25	30	20	moiety	moiety	NN
cord-305737-bnzd7b25	30	21	by	by	IN
cord-305737-bnzd7b25	30	22	RIG	rig	NN
cord-305737-bnzd7b25	30	23	-	-	:
cord-305737-bnzd7b25	30	24	I	I	NNP
cord-305737-bnzd7b25	30	25	,	,	,
cord-305737-bnzd7b25	30	26	a	a	DT
cord-305737-bnzd7b25	30	27	member	member	NN
cord-305737-bnzd7b25	30	28	of	of	IN
cord-305737-bnzd7b25	30	29	the	the	DT
cord-305737-bnzd7b25	30	30	RLR	RLR	NNP
cord-305737-bnzd7b25	30	31	family	family	NN
cord-305737-bnzd7b25	30	32	.	.	.
cord-305737-bnzd7b25	31	1	5PPP	5ppp	CD
cord-305737-bnzd7b25	31	2	groups	group	NNS
cord-305737-bnzd7b25	31	3	are	be	VBP
cord-305737-bnzd7b25	31	4	present	present	JJ
cord-305737-bnzd7b25	31	5	on	on	IN
cord-305737-bnzd7b25	31	6	the	the	DT
cord-305737-bnzd7b25	31	7	genomes	genome	NNS
cord-305737-bnzd7b25	31	8	of	of	IN
cord-305737-bnzd7b25	31	9	many	many	JJ
cord-305737-bnzd7b25	31	10	RNA	RNA	NNP
cord-305737-bnzd7b25	31	11	viruses	virus	NNS
cord-305737-bnzd7b25	31	12	(	(	-LRB-
cord-305737-bnzd7b25	31	13	Table	table	NN
cord-305737-bnzd7b25	31	14	1	1	CD
cord-305737-bnzd7b25	31	15	)	)	-RRB-
cord-305737-bnzd7b25	31	16	,	,	,
cord-305737-bnzd7b25	31	17	but	but	CC
cord-305737-bnzd7b25	31	18	are	be	VBP
cord-305737-bnzd7b25	31	19	not	not	RB
cord-305737-bnzd7b25	31	20	found	find	VBN
cord-305737-bnzd7b25	31	21	on	on	IN
cord-305737-bnzd7b25	31	22	most	most	JJS
cord-305737-bnzd7b25	31	23	cellular	cellular	JJ
cord-305737-bnzd7b25	31	24	RNAs	rna	NNS
cord-305737-bnzd7b25	31	25	in	in	IN
cord-305737-bnzd7b25	31	26	the	the	DT
cord-305737-bnzd7b25	31	27	cytosol	cytosol	NN
cord-305737-bnzd7b25	31	28	.	.	.
cord-305737-bnzd7b25	32	1	As	as	IN
cord-305737-bnzd7b25	32	2	such	such	JJ
cord-305737-bnzd7b25	32	3	,	,	,
cord-305737-bnzd7b25	32	4	the	the	DT
cord-305737-bnzd7b25	32	5	presence	presence	NN
cord-305737-bnzd7b25	32	6	of	of	IN
cord-305737-bnzd7b25	32	7	5PPP	5ppp	CD
cord-305737-bnzd7b25	32	8	RNA	RNA	NNP
cord-305737-bnzd7b25	32	9	in	in	IN
cord-305737-bnzd7b25	32	10	the	the	DT
cord-305737-bnzd7b25	32	11	cytoplasm	cytoplasm	NN
cord-305737-bnzd7b25	32	12	is	be	VBZ
cord-305737-bnzd7b25	32	13	a	a	DT
cord-305737-bnzd7b25	32	14	molecular	molecular	JJ
cord-305737-bnzd7b25	32	15	signature	signature	NN
cord-305737-bnzd7b25	32	16	of	of	IN
cord-305737-bnzd7b25	32	17	virus	virus	NN
cord-305737-bnzd7b25	32	18	infection	infection	NN
cord-305737-bnzd7b25	32	19	.	.	.
cord-305737-bnzd7b25	33	1	Secreted	secrete	VBN
cord-305737-bnzd7b25	33	2	IFN	IFN	NNP
cord-305737-bnzd7b25	33	3	acts	act	VBZ
cord-305737-bnzd7b25	33	4	in	in	IN
cord-305737-bnzd7b25	33	5	autocrine	autocrine	JJ
cord-305737-bnzd7b25	33	6	and	and	CC
cord-305737-bnzd7b25	33	7	paracrine	paracrine	JJ
cord-305737-bnzd7b25	33	8	fashion	fashion	NN
cord-305737-bnzd7b25	33	9	to	to	TO
cord-305737-bnzd7b25	33	10	turn	turn	VB
cord-305737-bnzd7b25	33	11	on	on	RP
cord-305737-bnzd7b25	33	12	the	the	DT
cord-305737-bnzd7b25	33	13	transcription	transcription	NN
cord-305737-bnzd7b25	33	14	of	of	IN
cord-305737-bnzd7b25	33	15	several	several	JJ
cord-305737-bnzd7b25	33	16	hundred	hundred	CD
cord-305737-bnzd7b25	33	17	IFN	IFN	NNP
cord-305737-bnzd7b25	33	18	-	-	HYPH
cord-305737-bnzd7b25	33	19	stimulated	stimulate	VBN
cord-305737-bnzd7b25	33	20	genes	gene	NNS
cord-305737-bnzd7b25	33	21	(	(	-LRB-
cord-305737-bnzd7b25	33	22	ISGs	ISGs	NNP
cord-305737-bnzd7b25	33	23	)	)	-RRB-
cord-305737-bnzd7b25	34	1	(	(	-LRB-
cord-305737-bnzd7b25	34	2	Figure	figure	NN
cord-305737-bnzd7b25	34	3	1	1	CD
cord-305737-bnzd7b25	34	4	)	)	-RRB-
cord-305737-bnzd7b25	34	5	[	[	-LRB-
cord-305737-bnzd7b25	34	6	5	5	CD
cord-305737-bnzd7b25	34	7	]	]	-RRB-
cord-305737-bnzd7b25	34	8	.	.	.
cord-305737-bnzd7b25	35	1	Examples	example	NNS
cord-305737-bnzd7b25	35	2	include	include	VBP
cord-305737-bnzd7b25	35	3	the	the	DT
cord-305737-bnzd7b25	35	4	genes	gene	NNS
cord-305737-bnzd7b25	35	5	encoding	encode	VBG
cord-305737-bnzd7b25	35	6	(	(	-LRB-
cord-305737-bnzd7b25	35	7	i	i	NN
cord-305737-bnzd7b25	35	8	)	)	-RRB-
cord-305737-bnzd7b25	35	9	RIG	rig	NN
cord-305737-bnzd7b25	35	10	-	-	:
cord-305737-bnzd7b25	35	11	I	I	NNP
cord-305737-bnzd7b25	35	12	and	and	CC
cord-305737-bnzd7b25	35	13	other	other	JJ
cord-305737-bnzd7b25	35	14	virus	virus	NN
cord-305737-bnzd7b25	35	15	sensing	sense	VBG
cord-305737-bnzd7b25	35	16	receptors	receptor	NNS
cord-305737-bnzd7b25	35	17	(	(	-LRB-
cord-305737-bnzd7b25	35	18	providing	provide	VBG
cord-305737-bnzd7b25	35	19	a	a	DT
cord-305737-bnzd7b25	35	20	positive	positive	JJ
cord-305737-bnzd7b25	35	21	-	-	HYPH
cord-305737-bnzd7b25	35	22	feedback	feedback	NN
cord-305737-bnzd7b25	35	23	loop	loop	NN
cord-305737-bnzd7b25	35	24	)	)	-RRB-
cord-305737-bnzd7b25	35	25	,	,	,
cord-305737-bnzd7b25	35	26	(	(	-LRB-
cord-305737-bnzd7b25	35	27	ii	ii	NN
cord-305737-bnzd7b25	35	28	)	)	-RRB-
cord-305737-bnzd7b25	35	29	proteins	protein	NNS
cord-305737-bnzd7b25	35	30	involved	involve	VBN
cord-305737-bnzd7b25	35	31	in	in	IN
cord-305737-bnzd7b25	35	32	cell	cell	NN
cord-305737-bnzd7b25	35	33	-	-	HYPH
cord-305737-bnzd7b25	35	34	intrinsic	intrinsic	JJ
cord-305737-bnzd7b25	35	35	anti	anti	JJ
cord-305737-bnzd7b25	35	36	-	-	JJ
cord-305737-bnzd7b25	35	37	viral	viral	JJ
cord-305737-bnzd7b25	35	38	defence	defence	NN
cord-305737-bnzd7b25	35	39	such	such	JJ
cord-305737-bnzd7b25	35	40	as	as	IN
cord-305737-bnzd7b25	35	41	RNaseL	RNaseL	NNP
cord-305737-bnzd7b25	35	42	,	,	,
cord-305737-bnzd7b25	35	43	MxA	MxA	NNP
cord-305737-bnzd7b25	35	44	or	or	CC
cord-305737-bnzd7b25	35	45	tetherin	tetherin	NNP
cord-305737-bnzd7b25	35	46	and	and	CC
cord-305737-bnzd7b25	35	47	(	(	-LRB-
cord-305737-bnzd7b25	35	48	iii	iii	NN
cord-305737-bnzd7b25	35	49	)	)	-RRB-
cord-305737-bnzd7b25	35	50	molecules	molecule	NNS
cord-305737-bnzd7b25	35	51	facilitating	facilitate	VBG
cord-305737-bnzd7b25	35	52	adaptive	adaptive	JJ
cord-305737-bnzd7b25	35	53	immune	immune	JJ
cord-305737-bnzd7b25	35	54	responses	response	NNS
cord-305737-bnzd7b25	35	55	such	such	JJ
cord-305737-bnzd7b25	35	56	as	as	IN
cord-305737-bnzd7b25	35	57	CD80	CD80	NNP
cord-305737-bnzd7b25	35	58	and	and	CC
cord-305737-bnzd7b25	35	59	CD86	CD86	NNP
cord-305737-bnzd7b25	35	60	.	.	.
cord-305737-bnzd7b25	36	1	One	one	CD
cord-305737-bnzd7b25	36	2	family	family	NN
cord-305737-bnzd7b25	36	3	of	of	IN
cord-305737-bnzd7b25	36	4	ISGs	ISGs	NNPS
cord-305737-bnzd7b25	36	5	encodes	encode	VBZ
cord-305737-bnzd7b25	36	6	the	the	DT
cord-305737-bnzd7b25	36	7	IFIT	ifit	NN
cord-305737-bnzd7b25	36	8	proteins	protein	NNS
cord-305737-bnzd7b25	36	9	that	that	WDT
cord-305737-bnzd7b25	36	10	are	be	VBP
cord-305737-bnzd7b25	36	11	characterized	characterize	VBN
cord-305737-bnzd7b25	36	12	by	by	IN
cord-305737-bnzd7b25	36	13	tetratricopeptide	tetratricopeptide	NNP
cord-305737-bnzd7b25	36	14	repeats	repeat	VBZ
cord-305737-bnzd7b25	36	15	[	[	-LRB-
cord-305737-bnzd7b25	36	16	6	6	CD
cord-305737-bnzd7b25	36	17	,	,	,
cord-305737-bnzd7b25	36	18	7	7	CD
cord-305737-bnzd7b25	36	19	]	]	-RRB-
cord-305737-bnzd7b25	36	20	.	.	.
cord-305737-bnzd7b25	37	1	IFITs	IFITs	NNP
cord-305737-bnzd7b25	37	2	control	control	NNP
cord-305737-bnzd7b25	37	3	translation	translation	NN
cord-305737-bnzd7b25	37	4	initiation	initiation	NN
cord-305737-bnzd7b25	37	5	,	,	,
cord-305737-bnzd7b25	37	6	cell	cell	NN
cord-305737-bnzd7b25	37	7	proliferation	proliferation	NN
cord-305737-bnzd7b25	37	8	and	and	CC
cord-305737-bnzd7b25	37	9	cell	cell	NN
cord-305737-bnzd7b25	37	10	migration	migration	NN
cord-305737-bnzd7b25	37	11	,	,	,
cord-305737-bnzd7b25	37	12	and	and	CC
cord-305737-bnzd7b25	37	13	exert	exert	VB
cord-305737-bnzd7b25	37	14	anti	anti	JJ
cord-305737-bnzd7b25	37	15	-	-	JJ
cord-305737-bnzd7b25	37	16	viral	viral	JJ
cord-305737-bnzd7b25	37	17	effects	effect	NNS
cord-305737-bnzd7b25	37	18	against	against	IN
cord-305737-bnzd7b25	37	19	a	a	DT
cord-305737-bnzd7b25	37	20	variety	variety	NN
cord-305737-bnzd7b25	37	21	of	of	IN
cord-305737-bnzd7b25	37	22	RNA	RNA	NNP
cord-305737-bnzd7b25	37	23	viruses	virus	NNS
cord-305737-bnzd7b25	37	24	and	and	CC
cord-305737-bnzd7b25	37	25	human	human	JJ
cord-305737-bnzd7b25	37	26	papillomavirus	papillomavirus	NN
cord-305737-bnzd7b25	37	27	[	[	-LRB-
cord-305737-bnzd7b25	37	28	6	6	CD
cord-305737-bnzd7b25	37	29	,	,	,
cord-305737-bnzd7b25	37	30	7	7	CD
cord-305737-bnzd7b25	37	31	]	]	-RRB-
cord-305737-bnzd7b25	37	32	.	.	.
cord-305737-bnzd7b25	38	1	Interestingly	interestingly	RB
cord-305737-bnzd7b25	38	2	,	,	,
cord-305737-bnzd7b25	38	3	it	-PRON-	PRP
cord-305737-bnzd7b25	38	4	has	have	VBZ
cord-305737-bnzd7b25	38	5	recently	recently	RB
cord-305737-bnzd7b25	38	6	been	be	VBN
cord-305737-bnzd7b25	38	7	found	find	VBN
cord-305737-bnzd7b25	38	8	that	that	IN
cord-305737-bnzd7b25	38	9	some	some	DT
cord-305737-bnzd7b25	38	10	IFITs	ifit	NNS
cord-305737-bnzd7b25	38	11	bind	bind	VBP
cord-305737-bnzd7b25	38	12	to	to	IN
cord-305737-bnzd7b25	38	13	5PPP	5ppp	CD
cord-305737-bnzd7b25	38	14	RNAs	rna	NNS
cord-305737-bnzd7b25	38	15	and	and	CC
cord-305737-bnzd7b25	38	16	antagonize	antagonize	VB
cord-305737-bnzd7b25	38	17	viruses	virus	NNS
cord-305737-bnzd7b25	38	18	by	by	IN
cord-305737-bnzd7b25	38	19	sequestering	sequester	VBG
cord-305737-bnzd7b25	38	20	viral	viral	JJ
cord-305737-bnzd7b25	38	21	RNA	RNA	NNP
cord-305737-bnzd7b25	38	22	[	[	-LRB-
cord-305737-bnzd7b25	38	23	8	8	CD
cord-305737-bnzd7b25	38	24	,	,	,
cord-305737-bnzd7b25	38	25	9	9	CD
cord-305737-bnzd7b25	38	26	]	]	-RRB-
cord-305737-bnzd7b25	38	27	.	.	.
cord-305737-bnzd7b25	39	1	Here	here	RB
cord-305737-bnzd7b25	39	2	,	,	,
cord-305737-bnzd7b25	39	3	we	-PRON-	PRP
cord-305737-bnzd7b25	39	4	review	review	VBP
cord-305737-bnzd7b25	39	5	recent	recent	JJ
cord-305737-bnzd7b25	39	6	progress	progress	NN
cord-305737-bnzd7b25	39	7	on	on	IN
cord-305737-bnzd7b25	39	8	the	the	DT
cord-305737-bnzd7b25	39	9	recognition	recognition	NN
cord-305737-bnzd7b25	39	10	of	of	IN
cord-305737-bnzd7b25	39	11	5PPP	5ppp	CD
cord-305737-bnzd7b25	39	12	RNA	RNA	NNP
cord-305737-bnzd7b25	39	13	by	by	IN
cord-305737-bnzd7b25	39	14	RIG	rig	NN
cord-305737-bnzd7b25	39	15	-	-	:
cord-305737-bnzd7b25	39	16	I	I	NNP
cord-305737-bnzd7b25	39	17	and	and	CC
cord-305737-bnzd7b25	39	18	IFITs	IFITs	NNPS
cord-305737-bnzd7b25	39	19	and	and	CC
cord-305737-bnzd7b25	39	20	its	-PRON-	PRP$
cord-305737-bnzd7b25	39	21	subsequent	subsequent	JJ
cord-305737-bnzd7b25	39	22	impact	impact	NN
cord-305737-bnzd7b25	39	23	on	on	IN
cord-305737-bnzd7b25	39	24	cell	cell	NN
cord-305737-bnzd7b25	39	25	-	-	HYPH
cord-305737-bnzd7b25	39	26	intrinsic	intrinsic	JJ
cord-305737-bnzd7b25	39	27	immunity	immunity	NN
cord-305737-bnzd7b25	39	28	to	to	IN
cord-305737-bnzd7b25	39	29	virus	virus	NN
cord-305737-bnzd7b25	39	30	infection	infection	NN
cord-305737-bnzd7b25	39	31	.	.	.
cord-305737-bnzd7b25	40	1	Studies	study	NNS
cord-305737-bnzd7b25	40	2	on	on	IN
cord-305737-bnzd7b25	40	3	the	the	DT
cord-305737-bnzd7b25	40	4	types	type	NNS
cord-305737-bnzd7b25	40	5	of	of	IN
cord-305737-bnzd7b25	40	6	RNA	RNA	NNP
cord-305737-bnzd7b25	40	7	that	that	WDT
cord-305737-bnzd7b25	40	8	can	can	MD
cord-305737-bnzd7b25	40	9	activate	activate	VB
cord-305737-bnzd7b25	40	10	RIG	rig	NN
cord-305737-bnzd7b25	41	1	-I	-I	NFP
cord-305737-bnzd7b25	41	2	have	have	VBP
cord-305737-bnzd7b25	41	3	attracted	attract	VBN
cord-305737-bnzd7b25	41	4	much	much	JJ
cord-305737-bnzd7b25	41	5	attention	attention	NN
cord-305737-bnzd7b25	41	6	but	but	CC
cord-305737-bnzd7b25	41	7	have	have	VBP
cord-305737-bnzd7b25	41	8	mostly	mostly	RB
cord-305737-bnzd7b25	41	9	been	be	VBN
cord-305737-bnzd7b25	41	10	based	base	VBN
cord-305737-bnzd7b25	41	11	on	on	IN
cord-305737-bnzd7b25	41	12	transfection	transfection	NN
cord-305737-bnzd7b25	41	13	of	of	IN
cord-305737-bnzd7b25	41	14	synthetic	synthetic	JJ
cord-305737-bnzd7b25	41	15	RNAs	rna	NNS
cord-305737-bnzd7b25	41	16	into	into	IN
cord-305737-bnzd7b25	41	17	reporter	reporter	NN
cord-305737-bnzd7b25	41	18	cells	cell	NNS
cord-305737-bnzd7b25	41	19	.	.	.
cord-305737-bnzd7b25	42	1	Such	such	JJ
cord-305737-bnzd7b25	42	2	experiments	experiment	NNS
cord-305737-bnzd7b25	42	3	revealed	reveal	VBD
cord-305737-bnzd7b25	42	4	that	that	IN
cord-305737-bnzd7b25	42	5	the	the	DT
cord-305737-bnzd7b25	42	6	most	most	RBS
cord-305737-bnzd7b25	42	7	potent	potent	JJ
cord-305737-bnzd7b25	42	8	RIG	rig	NN
cord-305737-bnzd7b25	42	9	-	-	:
cord-305737-bnzd7b25	42	10	I	-PRON-	PRP
cord-305737-bnzd7b25	42	11	agonists	agonist	NNS
cord-305737-bnzd7b25	42	12	are	be	VBP
cord-305737-bnzd7b25	42	13	RNAs	rna	NNS
cord-305737-bnzd7b25	42	14	that	that	WDT
cord-305737-bnzd7b25	42	15	contain	contain	VBP
cord-305737-bnzd7b25	42	16	a	a	DT
cord-305737-bnzd7b25	42	17	triphosphate	triphosphate	NN
cord-305737-bnzd7b25	42	18	moiety	moiety	NN
cord-305737-bnzd7b25	42	19	and	and	CC
cord-305737-bnzd7b25	42	20	are	be	VBP
cord-305737-bnzd7b25	42	21	base	base	NN
cord-305737-bnzd7b25	42	22	-	-	HYPH
cord-305737-bnzd7b25	42	23	paired	pair	VBN
cord-305737-bnzd7b25	42	24	at	at	IN
cord-305737-bnzd7b25	42	25	the	the	DT
cord-305737-bnzd7b25	42	26	5	5	CD
cord-305737-bnzd7b25	42	27	0	0	CD
cord-305737-bnzd7b25	42	28	-end	-end	CD
cord-305737-bnzd7b25	42	29	.	.	.
cord-305737-bnzd7b25	43	1	RNA	RNA	NNP
cord-305737-bnzd7b25	43	2	sequence	sequence	NN
cord-305737-bnzd7b25	43	3	is	be	VBZ
cord-305737-bnzd7b25	43	4	largely	largely	RB
cord-305737-bnzd7b25	43	5	irrelevant	irrelevant	JJ
cord-305737-bnzd7b25	43	6	so	so	RB
cord-305737-bnzd7b25	43	7	long	long	RB
cord-305737-bnzd7b25	43	8	as	as	IN
cord-305737-bnzd7b25	43	9	it	-PRON-	PRP
cord-305737-bnzd7b25	43	10	does	do	VBZ
cord-305737-bnzd7b25	43	11	not	not	RB
cord-305737-bnzd7b25	43	12	impact	impact	VB
cord-305737-bnzd7b25	43	13	on	on	IN
cord-305737-bnzd7b25	43	14	the	the	DT
cord-305737-bnzd7b25	43	15	base	base	NN
cord-305737-bnzd7b25	43	16	-	-	HYPH
cord-305737-bnzd7b25	43	17	pairing	pairing	NN
cord-305737-bnzd7b25	43	18	.	.	.
cord-305737-bnzd7b25	44	1	A	a	DT
cord-305737-bnzd7b25	44	2	blunt	blunt	JJ
cord-305737-bnzd7b25	44	3	end	end	NN
cord-305737-bnzd7b25	44	4	without	without	IN
cord-305737-bnzd7b25	44	5	overhangs	overhang	NNS
cord-305737-bnzd7b25	44	6	is	be	VBZ
cord-305737-bnzd7b25	44	7	most	most	RBS
cord-305737-bnzd7b25	44	8	effective	effective	JJ
cord-305737-bnzd7b25	44	9	and	and	CC
cord-305737-bnzd7b25	44	10	can	can	MD
cord-305737-bnzd7b25	44	11	be	be	VB
cord-305737-bnzd7b25	44	12	provided	provide	VBN
cord-305737-bnzd7b25	44	13	in	in	IN
cord-305737-bnzd7b25	44	14	trans	trans	NNP
cord-305737-bnzd7b25	44	15	by	by	IN
cord-305737-bnzd7b25	44	16	hybridization	hybridization	NN
cord-305737-bnzd7b25	44	17	between	between	IN
cord-305737-bnzd7b25	44	18	two	two	CD
cord-305737-bnzd7b25	44	19	RNA	RNA	NNP
cord-305737-bnzd7b25	44	20	molecules	molecule	NNS
cord-305737-bnzd7b25	44	21	or	or	CC
cord-305737-bnzd7b25	44	22	in	in	IN
cord-305737-bnzd7b25	44	23	cis	cis	NNP
cord-305737-bnzd7b25	44	24	by	by	IN
cord-305737-bnzd7b25	44	25	complementarity	complementarity	NN
cord-305737-bnzd7b25	44	26	between	between	IN
cord-305737-bnzd7b25	44	27	the	the	DT
cord-305737-bnzd7b25	44	28	5	5	CD
cord-305737-bnzd7b25	44	29	0end	0end	CD
cord-305737-bnzd7b25	44	30	and	and	CC
cord-305737-bnzd7b25	44	31	3	3	CD
cord-305737-bnzd7b25	44	32	0	0	CD
cord-305737-bnzd7b25	45	1	-end	-end	:
cord-305737-bnzd7b25	45	2	of	of	IN
cord-305737-bnzd7b25	45	3	a	a	DT
cord-305737-bnzd7b25	45	4	single	single	JJ
cord-305737-bnzd7b25	45	5	RNA	RNA	NNP
cord-305737-bnzd7b25	45	6	molecule	molecule	NN
cord-305737-bnzd7b25	45	7	(	(	-LRB-
cord-305737-bnzd7b25	45	8	Figure	figure	NN
cord-305737-bnzd7b25	45	9	2a	2a	CD
cord-305737-bnzd7b25	45	10	)	)	-RRB-
cord-305737-bnzd7b25	45	11	.	.	.
cord-305737-bnzd7b25	46	1	These	these	DT
cord-305737-bnzd7b25	46	2	findings	finding	NNS
cord-305737-bnzd7b25	46	3	have	have	VBP
cord-305737-bnzd7b25	46	4	been	be	VBN
cord-305737-bnzd7b25	46	5	reviewed	review	VBN
cord-305737-bnzd7b25	46	6	in	in	IN
cord-305737-bnzd7b25	46	7	detail	detail	NN
cord-305737-bnzd7b25	46	8	elsewhere	elsewhere	RB
cord-305737-bnzd7b25	46	9	[	[	-LRB-
cord-305737-bnzd7b25	46	10	10	10	CD
cord-305737-bnzd7b25	46	11	,	,	,
cord-305737-bnzd7b25	46	12	11	11	CD
cord-305737-bnzd7b25	46	13	]	]	-RRB-
cord-305737-bnzd7b25	46	14	and	and	CC
cord-305737-bnzd7b25	46	15	are	be	VBP
cord-305737-bnzd7b25	46	16	well	well	RB
cord-305737-bnzd7b25	46	17	supported	support	VBN
cord-305737-bnzd7b25	46	18	by	by	IN
cord-305737-bnzd7b25	46	19	structural	structural	JJ
cord-305737-bnzd7b25	46	20	data	datum	NNS
cord-305737-bnzd7b25	46	21	(	(	-LRB-
cord-305737-bnzd7b25	46	22	see	see	VB
cord-305737-bnzd7b25	46	23	below	below	RB
cord-305737-bnzd7b25	46	24	)	)	-RRB-
cord-305737-bnzd7b25	46	25	.	.	.
cord-305737-bnzd7b25	47	1	Less	Less	JJR
cord-305737-bnzd7b25	47	2	is	be	VBZ
cord-305737-bnzd7b25	47	3	known	know	VBN
cord-305737-bnzd7b25	47	4	about	about	IN
cord-305737-bnzd7b25	47	5	the	the	DT
cord-305737-bnzd7b25	47	6	types	type	NNS
cord-305737-bnzd7b25	47	7	of	of	IN
cord-305737-bnzd7b25	47	8	RNA	RNA	NNP
cord-305737-bnzd7b25	47	9	that	that	WDT
cord-305737-bnzd7b25	47	10	activate	activate	VBP
cord-305737-bnzd7b25	47	11	RIG	rig	NN
cord-305737-bnzd7b25	47	12	-	-	:
cord-305737-bnzd7b25	47	13	I	-PRON-	PRP
cord-305737-bnzd7b25	47	14	during	during	IN
cord-305737-bnzd7b25	47	15	virus	virus	NN
cord-305737-bnzd7b25	47	16	infection	infection	NN
cord-305737-bnzd7b25	47	17	.	.	.
cord-305737-bnzd7b25	48	1	However	however	RB
cord-305737-bnzd7b25	48	2	,	,	,
cord-305737-bnzd7b25	48	3	work	work	VB
cord-305737-bnzd7b25	48	4	from	from	IN
cord-305737-bnzd7b25	48	5	us	-PRON-	PRP
cord-305737-bnzd7b25	48	6	and	and	CC
cord-305737-bnzd7b25	48	7	others	other	NNS
cord-305737-bnzd7b25	48	8	showed	show	VBD
cord-305737-bnzd7b25	48	9	that	that	IN
cord-305737-bnzd7b25	48	10	RIG	rig	NN
cord-305737-bnzd7b25	48	11	-	-	:
cord-305737-bnzd7b25	48	12	I	-PRON-	PRP
cord-305737-bnzd7b25	48	13	recognizes	recognize	VBZ
cord-305737-bnzd7b25	48	14	the	the	DT
cord-305737-bnzd7b25	48	15	5PPP	5ppp	CD
cord-305737-bnzd7b25	48	16	RNA	RNA	NNP
cord-305737-bnzd7b25	48	17	genome	genome	NN
cord-305737-bnzd7b25	48	18	of	of	IN
cord-305737-bnzd7b25	48	19	influenza	influenza	NN
cord-305737-bnzd7b25	48	20	A	a	DT
cord-305737-bnzd7b25	48	21	virus	virus	NN
cord-305737-bnzd7b25	48	22	(	(	-LRB-
cord-305737-bnzd7b25	48	23	IAV	IAV	NNP
cord-305737-bnzd7b25	48	24	)	)	-RRB-
cord-305737-bnzd7b25	48	25	and	and	CC
cord-305737-bnzd7b25	48	26	Sendai	Sendai	NNP
cord-305737-bnzd7b25	48	27	virus	virus	NN
cord-305737-bnzd7b25	48	28	in	in	IN
cord-305737-bnzd7b25	48	29	infected	infected	JJ
cord-305737-bnzd7b25	48	30	cells	cell	NNS
cord-305737-bnzd7b25	48	31	,	,	,
cord-305737-bnzd7b25	48	32	and	and	CC
cord-305737-bnzd7b25	48	33	that	that	IN
cord-305737-bnzd7b25	48	34	both	both	CC
cord-305737-bnzd7b25	48	35	the	the	DT
cord-305737-bnzd7b25	48	36	5PPP	5ppp	CD
cord-305737-bnzd7b25	48	37	and	and	CC
cord-305737-bnzd7b25	48	38	the	the	DT
cord-305737-bnzd7b25	48	39	secondary	secondary	JJ
cord-305737-bnzd7b25	48	40	structure	structure	NN
cord-305737-bnzd7b25	48	41	are	be	VBP
cord-305737-bnzd7b25	48	42	required	require	VBN
cord-305737-bnzd7b25	48	43	for	for	IN
cord-305737-bnzd7b25	48	44	RIG	rig	NN
cord-305737-bnzd7b25	48	45	-	-	HYPH
cord-305737-bnzd7b25	48	46	I	i	NN
cord-305737-bnzd7b25	48	47	-	-	HYPH
cord-305737-bnzd7b25	48	48	dependent	dependent	JJ
cord-305737-bnzd7b25	48	49	IFN	IFN	NNP
cord-305737-bnzd7b25	48	50	induction	induction	NN
cord-305737-bnzd7b25	48	51	[	[	-LRB-
cord-305737-bnzd7b25	48	52	12	12	CD
cord-305737-bnzd7b25	48	53	,	,	,
cord-305737-bnzd7b25	48	54	13	13	CD
cord-305737-bnzd7b25	48	55	]	]	-RRB-
cord-305737-bnzd7b25	48	56	.	.	.
cord-305737-bnzd7b25	49	1	Thus	thus	RB
cord-305737-bnzd7b25	49	2	,	,	,
cord-305737-bnzd7b25	49	3	these	these	DT
cord-305737-bnzd7b25	49	4	two	two	CD
cord-305737-bnzd7b25	49	5	studies	study	NNS
cord-305737-bnzd7b25	49	6	in	in	IN
cord-305737-bnzd7b25	49	7	virus	virus	NN
cord-305737-bnzd7b25	49	8	infection	infection	NN
cord-305737-bnzd7b25	49	9	models	model	NNS
cord-305737-bnzd7b25	49	10	nicely	nicely	RB
cord-305737-bnzd7b25	49	11	validate	validate	VBP
cord-305737-bnzd7b25	49	12	the	the	DT
cord-305737-bnzd7b25	49	13	predictions	prediction	NNS
cord-305737-bnzd7b25	49	14	made	make	VBN
cord-305737-bnzd7b25	49	15	by	by	IN
cord-305737-bnzd7b25	49	16	analysis	analysis	NN
cord-305737-bnzd7b25	49	17	of	of	IN
cord-305737-bnzd7b25	49	18	the	the	DT
cord-305737-bnzd7b25	49	19	RIG	rig	NN
cord-305737-bnzd7b25	49	20	-	-	HYPH
cord-305737-bnzd7b25	49	21	I	i	NN
cord-305737-bnzd7b25	49	22	-	-	HYPH
cord-305737-bnzd7b25	49	23	mediated	mediate	VBN
cord-305737-bnzd7b25	49	24	response	response	NN
cord-305737-bnzd7b25	49	25	to	to	IN
cord-305737-bnzd7b25	49	26	synthetic	synthetic	JJ
cord-305737-bnzd7b25	49	27	RNAs	rna	NNS
cord-305737-bnzd7b25	49	28	[	[	-LRB-
cord-305737-bnzd7b25	49	29	12	12	CD
cord-305737-bnzd7b25	49	30	,	,	,
cord-305737-bnzd7b25	49	31	13	13	CD
cord-305737-bnzd7b25	49	32	]	]	-RRB-
cord-305737-bnzd7b25	49	33	.	.	.
cord-305737-bnzd7b25	50	1	Recent	recent	JJ
cord-305737-bnzd7b25	50	2	work	work	NN
cord-305737-bnzd7b25	50	3	shows	show	VBZ
cord-305737-bnzd7b25	50	4	that	that	IN
cord-305737-bnzd7b25	50	5	RIG	rig	NN
cord-305737-bnzd7b25	50	6	-	-	:
cord-305737-bnzd7b25	50	7	I	-PRON-	PRP
cord-305737-bnzd7b25	50	8	is	be	VBZ
cord-305737-bnzd7b25	50	9	recruited	recruit	VBN
cord-305737-bnzd7b25	50	10	to	to	IN
cord-305737-bnzd7b25	50	11	and	and	CC
cord-305737-bnzd7b25	50	12	activated	activate	VBN
cord-305737-bnzd7b25	50	13	by	by	IN
cord-305737-bnzd7b25	50	14	bunyavirus	bunyavirus	NNP
cord-305737-bnzd7b25	50	15	nucleocapsids	nucleocapsids	NNP
cord-305737-bnzd7b25	50	16	,	,	,
cord-305737-bnzd7b25	50	17	native	native	JJ
cord-305737-bnzd7b25	50	18	complexes	complex	NNS
cord-305737-bnzd7b25	50	19	containing	contain	VBG
cord-305737-bnzd7b25	50	20	a	a	DT
cord-305737-bnzd7b25	50	21	5PPP	5ppp	CD
cord-305737-bnzd7b25	50	22	RNA	RNA	NNP
cord-305737-bnzd7b25	50	23	genome	genome	NN
cord-305737-bnzd7b25	50	24	and	and	CC
cord-305737-bnzd7b25	50	25	viral	viral	JJ
cord-305737-bnzd7b25	50	26	proteins	protein	NNS
cord-305737-bnzd7b25	50	27	[	[	-LRB-
cord-305737-bnzd7b25	50	28	14	14	CD
cord-305737-bnzd7b25	50	29	]	]	-RRB-
cord-305737-bnzd7b25	50	30	.	.	.
cord-305737-bnzd7b25	51	1	This	this	DT
cord-305737-bnzd7b25	51	2	demonstrates	demonstrate	VBZ
cord-305737-bnzd7b25	51	3	that	that	IN
cord-305737-bnzd7b25	51	4	RIG	rig	NN
cord-305737-bnzd7b25	51	5	-	-	:
cord-305737-bnzd7b25	51	6	I	-PRON-	PRP
cord-305737-bnzd7b25	51	7	can	can	MD
cord-305737-bnzd7b25	51	8	indeed	indeed	RB
cord-305737-bnzd7b25	51	9	gain	gain	VB
cord-305737-bnzd7b25	51	10	access	access	NN
cord-305737-bnzd7b25	51	11	to	to	IN
cord-305737-bnzd7b25	51	12	viral	viral	JJ
cord-305737-bnzd7b25	51	13	RNAs	rna	NNS
cord-305737-bnzd7b25	51	14	under	under	IN
cord-305737-bnzd7b25	51	15	physiological	physiological	JJ
cord-305737-bnzd7b25	51	16	conditions	condition	NNS
cord-305737-bnzd7b25	51	17	.	.	.
cord-305737-bnzd7b25	52	1	Like	like	IN
cord-305737-bnzd7b25	52	2	viral	viral	JJ
cord-305737-bnzd7b25	52	3	RNA	RNA	NNP
cord-305737-bnzd7b25	52	4	,	,	,
cord-305737-bnzd7b25	52	5	bacterial	bacterial	JJ
cord-305737-bnzd7b25	52	6	RNAs	rna	NNS
cord-305737-bnzd7b25	52	7	can	can	MD
cord-305737-bnzd7b25	52	8	possess	possess	VB
cord-305737-bnzd7b25	52	9	5PPP	5ppp	CD
cord-305737-bnzd7b25	52	10	termini	terminus	NNS
cord-305737-bnzd7b25	52	11	and	and	CC
cord-305737-bnzd7b25	52	12	secondary	secondary	JJ
cord-305737-bnzd7b25	52	13	structures	structure	NNS
cord-305737-bnzd7b25	52	14	that	that	WDT
cord-305737-bnzd7b25	52	15	are	be	VBP
cord-305737-bnzd7b25	52	16	predicted	predict	VBN
cord-305737-bnzd7b25	52	17	to	to	TO
cord-305737-bnzd7b25	52	18	make	make	VB
cord-305737-bnzd7b25	52	19	them	-PRON-	PRP
cord-305737-bnzd7b25	52	20	RIG	rig	NN
cord-305737-bnzd7b25	52	21	-	-	:
cord-305737-bnzd7b25	52	22	I	-PRON-	PRP
cord-305737-bnzd7b25	52	23	agonists	agonist	NNS
cord-305737-bnzd7b25	52	24	.	.	.
cord-305737-bnzd7b25	53	1	Consistent	consistent	JJ
cord-305737-bnzd7b25	53	2	with	with	IN
cord-305737-bnzd7b25	53	3	this	this	DT
cord-305737-bnzd7b25	53	4	notion	notion	NN
cord-305737-bnzd7b25	53	5	,	,	,
cord-305737-bnzd7b25	53	6	RIG	rig	NN
cord-305737-bnzd7b25	53	7	-	-	:
cord-305737-bnzd7b25	53	8	I	-PRON-	PRP
cord-305737-bnzd7b25	53	9	can	can	MD
cord-305737-bnzd7b25	53	10	act	act	VB
cord-305737-bnzd7b25	53	11	as	as	IN
cord-305737-bnzd7b25	53	12	a	a	DT
cord-305737-bnzd7b25	53	13	sensor	sensor	NN
cord-305737-bnzd7b25	53	14	of	of	IN
cord-305737-bnzd7b25	53	15	bacterial	bacterial	JJ
cord-305737-bnzd7b25	53	16	RNA	RNA	NNP
cord-305737-bnzd7b25	53	17	and	and	CC
cord-305737-bnzd7b25	53	18	may	may	MD
cord-305737-bnzd7b25	53	19	help	help	VB
cord-305737-bnzd7b25	53	20	maintain	maintain	VB
cord-305737-bnzd7b25	53	21	homeostasis	homeostasis	NN
cord-305737-bnzd7b25	53	22	to	to	TO
cord-305737-bnzd7b25	53	23	gut	gut	VB
cord-305737-bnzd7b25	53	24	microbiota	microbiota	NNS
cord-305737-bnzd7b25	53	25	[	[	-LRB-
cord-305737-bnzd7b25	53	26	15	15	CD
cord-305737-bnzd7b25	53	27	,	,	,
cord-305737-bnzd7b25	53	28	16	16	CD
cord-305737-bnzd7b25	53	29	]	]	-RRB-
cord-305737-bnzd7b25	53	30	.	.	.
cord-305737-bnzd7b25	54	1	Interestingly	interestingly	RB
cord-305737-bnzd7b25	54	2	,	,	,
cord-305737-bnzd7b25	54	3	some	some	DT
cord-305737-bnzd7b25	54	4	RNAs	rna	NNS
cord-305737-bnzd7b25	54	5	lacking	lack	VBG
cord-305737-bnzd7b25	54	6	5PPPs	5ppps	NN
cord-305737-bnzd7b25	54	7	also	also	RB
cord-305737-bnzd7b25	54	8	trigger	trigger	NN
cord-305737-bnzd7b25	54	9	RIG	rig	NN
cord-305737-bnzd7b25	54	10	-	-	:
cord-305737-bnzd7b25	54	11	I	-PRON-	PRP
cord-305737-bnzd7b25	54	12	upon	upon	IN
cord-305737-bnzd7b25	54	13	transfection	transfection	NN
cord-305737-bnzd7b25	54	14	into	into	IN
cord-305737-bnzd7b25	54	15	cells	cell	NNS
cord-305737-bnzd7b25	54	16	.	.	.
cord-305737-bnzd7b25	55	1	These	these	DT
cord-305737-bnzd7b25	55	2	RNAs	rna	NNS
cord-305737-bnzd7b25	55	3	include	include	VBP
cord-305737-bnzd7b25	55	4	short	short	JJ
cord-305737-bnzd7b25	55	5	double	double	RB
cord-305737-bnzd7b25	55	6	-	-	HYPH
cord-305737-bnzd7b25	55	7	stranded	stranded	JJ
cord-305737-bnzd7b25	55	8	RNAs	rna	NNS
cord-305737-bnzd7b25	55	9	made	make	VBN
cord-305737-bnzd7b25	55	10	by	by	IN
cord-305737-bnzd7b25	55	11	chemical	chemical	NN
cord-305737-bnzd7b25	55	12	synthesis	synthesis	NN
cord-305737-bnzd7b25	55	13	486	486	CD
cord-305737-bnzd7b25	55	14	Host	host	NN
cord-305737-bnzd7b25	55	15	-	-	HYPH
cord-305737-bnzd7b25	55	16	microbe	microbe	NN
cord-305737-bnzd7b25	55	17	interactions	interaction	NNS
cord-305737-bnzd7b25	55	18	:	:	:
cord-305737-bnzd7b25	55	19	viruses	virus	NNS
cord-305737-bnzd7b25	55	20	[	[	-LRB-
cord-305737-bnzd7b25	55	21	52	52	CD
cord-305737-bnzd7b25	55	22	]	]	-RRB-
cord-305737-bnzd7b25	56	1	a	a	DT
cord-305737-bnzd7b25	56	2	IFIT1	ifit1	NN
cord-305737-bnzd7b25	56	3	inhibits	inhibit	VBZ
cord-305737-bnzd7b25	56	4	viral	viral	JJ
cord-305737-bnzd7b25	56	5	mRNA	mRNA	NNP
cord-305737-bnzd7b25	56	6	translation	translation	NN
cord-305737-bnzd7b25	56	7	of	of	IN
cord-305737-bnzd7b25	56	8	parainfluenza	parainfluenza	NNP
cord-305737-bnzd7b25	56	9	virus	virus	NNP
cord-305737-bnzd7b25	56	10	type	type	NNP
cord-305737-bnzd7b25	56	11	5	5	CD
cord-305737-bnzd7b25	56	12	,	,	,
cord-305737-bnzd7b25	56	13	another	another	DT
cord-305737-bnzd7b25	56	14	member	member	NN
cord-305737-bnzd7b25	56	15	of	of	IN
cord-305737-bnzd7b25	56	16	the	the	DT
cord-305737-bnzd7b25	56	17	paramyxovirus	paramyxovirus	NNP
cord-305737-bnzd7b25	56	18	family	family	NN
cord-305737-bnzd7b25	56	19	[	[	-LRB-
cord-305737-bnzd7b25	56	20	54	54	CD
cord-305737-bnzd7b25	56	21	]	]	-RRB-
cord-305737-bnzd7b25	56	22	.	.	.
cord-305737-bnzd7b25	57	1	The	the	DT
cord-305737-bnzd7b25	57	2	mechanism	mechanism	NN
cord-305737-bnzd7b25	57	3	of	of	IN
cord-305737-bnzd7b25	57	4	inhibition	inhibition	NN
cord-305737-bnzd7b25	57	5	is	be	VBZ
cord-305737-bnzd7b25	57	6	unknown	unknown	JJ
cord-305737-bnzd7b25	57	7	but	but	CC
cord-305737-bnzd7b25	57	8	is	be	VBZ
cord-305737-bnzd7b25	57	9	unlikely	unlikely	JJ
cord-305737-bnzd7b25	57	10	to	to	TO
cord-305737-bnzd7b25	57	11	involve	involve	VB
cord-305737-bnzd7b25	57	12	5PPP	5ppp	CD
cord-305737-bnzd7b25	57	13	RNA	RNA	NNP
cord-305737-bnzd7b25	57	14	binding	bind	VBG
cord-305737-bnzd7b25	57	15	as	as	IN
cord-305737-bnzd7b25	57	16	viral	viral	JJ
cord-305737-bnzd7b25	57	17	mRNAs	mRNAs	NNPS
cord-305737-bnzd7b25	57	18	are	be	VBP
cord-305737-bnzd7b25	57	19	capped	cap	VBN
cord-305737-bnzd7b25	57	20	.	.	.
cord-305737-bnzd7b25	58	1	[	[	-LRB-
cord-305737-bnzd7b25	58	2	17	17	CD
cord-305737-bnzd7b25	58	3	,	,	,
cord-305737-bnzd7b25	58	4	18	18	CD
cord-305737-bnzd7b25	58	5	]	]	-RRB-
cord-305737-bnzd7b25	58	6	,	,	,
cord-305737-bnzd7b25	58	7	certain	certain	JJ
cord-305737-bnzd7b25	58	8	forms	form	NNS
cord-305737-bnzd7b25	58	9	of	of	IN
cord-305737-bnzd7b25	58	10	the	the	DT
cord-305737-bnzd7b25	58	11	enzymatically	enzymatically	RB
cord-305737-bnzd7b25	58	12	prepared	prepare	VBN
cord-305737-bnzd7b25	58	13	RNA	RNA	NNP
cord-305737-bnzd7b25	58	14	poly	poly	NN
cord-305737-bnzd7b25	58	15	I	i	NN
cord-305737-bnzd7b25	58	16	:	:	:
cord-305737-bnzd7b25	58	17	C	C	NNP
cord-305737-bnzd7b25	58	18	[	[	-LRB-
cord-305737-bnzd7b25	58	19	19	19	CD
cord-305737-bnzd7b25	58	20	]	]	-RRB-
cord-305737-bnzd7b25	58	21	and	and	CC
cord-305737-bnzd7b25	58	22	dephosphorylated	dephosphorylate	VBD
cord-305737-bnzd7b25	58	23	double	double	RB
cord-305737-bnzd7b25	58	24	-	-	HYPH
cord-305737-bnzd7b25	58	25	stranded	stranded	JJ
cord-305737-bnzd7b25	58	26	RNAs	rna	NNS
cord-305737-bnzd7b25	58	27	made	make	VBN
cord-305737-bnzd7b25	58	28	by	by	IN
cord-305737-bnzd7b25	58	29	in	in	FW
cord-305737-bnzd7b25	58	30	vitro	vitro	FW
cord-305737-bnzd7b25	58	31	transcription	transcription	NN
cord-305737-bnzd7b25	58	32	[	[	-LRB-
cord-305737-bnzd7b25	58	33	20	20	CD
cord-305737-bnzd7b25	58	34	]	]	-RRB-
cord-305737-bnzd7b25	58	35	.	.	.
cord-305737-bnzd7b25	59	1	Further	further	RB
cord-305737-bnzd7b25	59	2	supporting	support	VBG
cord-305737-bnzd7b25	59	3	the	the	DT
cord-305737-bnzd7b25	59	4	notion	notion	NN
cord-305737-bnzd7b25	59	5	that	that	IN
cord-305737-bnzd7b25	59	6	non-5PPP	non-5ppp	IN
cord-305737-bnzd7b25	59	7	RNAs	rna	NNS
cord-305737-bnzd7b25	59	8	can	can	MD
cord-305737-bnzd7b25	59	9	activate	activate	VB
cord-305737-bnzd7b25	59	10	RIG	rig	NN
cord-305737-bnzd7b25	59	11	-	-	:
cord-305737-bnzd7b25	59	12	I	-PRON-	PRP
cord-305737-bnzd7b25	59	13	is	be	VBZ
cord-305737-bnzd7b25	59	14	the	the	DT
cord-305737-bnzd7b25	59	15	observation	observation	NN
cord-305737-bnzd7b25	59	16	that	that	IN
cord-305737-bnzd7b25	59	17	poly	poly	NNP
cord-305737-bnzd7b25	59	18	I	I	NNP
cord-305737-bnzd7b25	59	19	:	:	:
cord-305737-bnzd7b25	59	20	C	C	NNP
cord-305737-bnzd7b25	59	21	triggers	trigger	VBZ
cord-305737-bnzd7b25	59	22	RIG	rig	NN
cord-305737-bnzd7b25	59	23	-	-	:
cord-305737-bnzd7b25	59	24	I	-PRON-	PRP
cord-305737-bnzd7b25	59	25	signalling	signal	VBG
cord-305737-bnzd7b25	59	26	in	in	IN
cord-305737-bnzd7b25	59	27	a	a	DT
cord-305737-bnzd7b25	59	28	cell	cell	NN
cord-305737-bnzd7b25	59	29	free	free	JJ
cord-305737-bnzd7b25	59	30	reconstitution	reconstitution	NN
cord-305737-bnzd7b25	59	31	assay	assay	NN
cord-305737-bnzd7b25	59	32	[	[	-LRB-
cord-305737-bnzd7b25	59	33	21	21	CD
cord-305737-bnzd7b25	59	34	]	]	-RRB-
cord-305737-bnzd7b25	59	35	.	.	.
cord-305737-bnzd7b25	60	1	However	however	RB
cord-305737-bnzd7b25	60	2	,	,	,
cord-305737-bnzd7b25	60	3	it	-PRON-	PRP
cord-305737-bnzd7b25	60	4	remains	remain	VBZ
cord-305737-bnzd7b25	60	5	unclear	unclear	JJ
cord-305737-bnzd7b25	60	6	whether	whether	IN
cord-305737-bnzd7b25	60	7	5PPP	5ppp	CD
cord-305737-bnzd7b25	60	8	-	-	HYPH
cord-305737-bnzd7b25	60	9	independent	independent	JJ
cord-305737-bnzd7b25	60	10	RIG	rig	NN
cord-305737-bnzd7b25	60	11	-	-	:
cord-305737-bnzd7b25	60	12	I	i	NN
cord-305737-bnzd7b25	60	13	signalling	signalling	NN
cord-305737-bnzd7b25	60	14	occurs	occur	VBZ
cord-305737-bnzd7b25	60	15	in	in	IN
cord-305737-bnzd7b25	60	16	infected	infected	JJ
cord-305737-bnzd7b25	60	17	cells	cell	NNS
cord-305737-bnzd7b25	60	18	.	.	.
cord-305737-bnzd7b25	61	1	It	-PRON-	PRP
cord-305737-bnzd7b25	61	2	will	will	MD
cord-305737-bnzd7b25	61	3	be	be	VB
cord-305737-bnzd7b25	61	4	important	important	JJ
cord-305737-bnzd7b25	61	5	to	to	TO
cord-305737-bnzd7b25	61	6	identify	identify	VB
cord-305737-bnzd7b25	61	7	natural	natural	JJ
cord-305737-bnzd7b25	61	8	RNAs	rna	NNS
cord-305737-bnzd7b25	61	9	that	that	WDT
cord-305737-bnzd7b25	61	10	activate	activate	VBP
cord-305737-bnzd7b25	61	11	RIG	rig	NN
cord-305737-bnzd7b25	61	12	-	-	:
cord-305737-bnzd7b25	61	13	I	-PRON-	PRP
cord-305737-bnzd7b25	61	14	in	in	IN
cord-305737-bnzd7b25	61	15	cells	cell	NNS
cord-305737-bnzd7b25	61	16	infected	infect	VBN
cord-305737-bnzd7b25	61	17	with	with	IN
cord-305737-bnzd7b25	61	18	different	different	JJ
cord-305737-bnzd7b25	61	19	viruses	virus	NNS
cord-305737-bnzd7b25	61	20	,	,	,
cord-305737-bnzd7b25	61	21	including	include	VBG
cord-305737-bnzd7b25	61	22	positive	positive	JJ
cord-305737-bnzd7b25	61	23	sense	sense	NN
cord-305737-bnzd7b25	61	24	RNA	RNA	NNP
cord-305737-bnzd7b25	61	25	viruses	virus	NNS
cord-305737-bnzd7b25	61	26	,	,	,
cord-305737-bnzd7b25	61	27	to	to	TO
cord-305737-bnzd7b25	61	28	validate	validate	VB
cord-305737-bnzd7b25	61	29	the	the	DT
cord-305737-bnzd7b25	61	30	extent	extent	NN
cord-305737-bnzd7b25	61	31	to	to	TO
cord-305737-bnzd7b25	61	32	which	which	WDT
cord-305737-bnzd7b25	61	33	RIG	rig	NN
cord-305737-bnzd7b25	61	34	-	-	:
cord-305737-bnzd7b25	61	35	I	-PRON-	PRP
cord-305737-bnzd7b25	61	36	can	can	MD
cord-305737-bnzd7b25	61	37	be	be	VB
cord-305737-bnzd7b25	61	38	activated	activate	VBN
cord-305737-bnzd7b25	61	39	independently	independently	RB
cord-305737-bnzd7b25	61	40	of	of	IN
cord-305737-bnzd7b25	61	41	5PPPs	5ppps	CD
cord-305737-bnzd7b25	61	42	.	.	.
cord-305737-bnzd7b25	62	1	magnetic	magnetic	JJ
cord-305737-bnzd7b25	62	2	resonance	resonance	NN
cord-305737-bnzd7b25	62	3	and	and	CC
cord-305737-bnzd7b25	62	4	X	x	NN
cord-305737-bnzd7b25	62	5	-	-	NN
cord-305737-bnzd7b25	62	6	ray	ray	NN
cord-305737-bnzd7b25	62	7	crystallography	crystallography	NN
cord-305737-bnzd7b25	62	8	elucidated	elucidate	VBD
cord-305737-bnzd7b25	62	9	the	the	DT
cord-305737-bnzd7b25	62	10	structure	structure	NN
cord-305737-bnzd7b25	62	11	of	of	IN
cord-305737-bnzd7b25	62	12	the	the	DT
cord-305737-bnzd7b25	62	13	CTD	CTD	NNP
cord-305737-bnzd7b25	62	14	in	in	IN
cord-305737-bnzd7b25	62	15	the	the	DT
cord-305737-bnzd7b25	62	16	absence	absence	NN
cord-305737-bnzd7b25	62	17	[	[	-LRB-
cord-305737-bnzd7b25	62	18	17	17	CD
cord-305737-bnzd7b25	62	19	,	,	,
cord-305737-bnzd7b25	62	20	24	24	CD
cord-305737-bnzd7b25	62	21	]	]	-RRB-
cord-305737-bnzd7b25	62	22	and	and	CC
cord-305737-bnzd7b25	62	23	presence	presence	NN
cord-305737-bnzd7b25	62	24	of	of	IN
cord-305737-bnzd7b25	62	25	RNA	RNA	NNP
cord-305737-bnzd7b25	62	26	[	[	-LRB-
cord-305737-bnzd7b25	62	27	25	25	CD
cord-305737-bnzd7b25	62	28	,	,	,
cord-305737-bnzd7b25	62	29	26	26	CD
cord-305737-bnzd7b25	62	30	,	,	,
cord-305737-bnzd7b25	62	31	27	27	CD
cord-305737-bnzd7b25	62	32	]	]	-RRB-
cord-305737-bnzd7b25	62	33	.	.	.
cord-305737-bnzd7b25	63	1	They	-PRON-	PRP
cord-305737-bnzd7b25	63	2	showed	show	VBD
cord-305737-bnzd7b25	63	3	that	that	IN
cord-305737-bnzd7b25	63	4	the	the	DT
cord-305737-bnzd7b25	63	5	CTD	CTD	NNP
cord-305737-bnzd7b25	63	6	contains	contain	VBZ
cord-305737-bnzd7b25	63	7	a	a	DT
cord-305737-bnzd7b25	63	8	positively	positively	RB
cord-305737-bnzd7b25	63	9	charged	charge	VBN
cord-305737-bnzd7b25	63	10	pocket	pocket	NN
cord-305737-bnzd7b25	63	11	that	that	WDT
cord-305737-bnzd7b25	63	12	can	can	MD
cord-305737-bnzd7b25	63	13	accommodate	accommodate	VB
cord-305737-bnzd7b25	63	14	5PPP	5ppp	CD
cord-305737-bnzd7b25	63	15	ends	end	NNS
cord-305737-bnzd7b25	63	16	of	of	IN
cord-305737-bnzd7b25	63	17	RNA	RNA	NNP
cord-305737-bnzd7b25	63	18	molecules	molecule	NNS
cord-305737-bnzd7b25	63	19	and	and	CC
cord-305737-bnzd7b25	63	20	thus	thus	RB
cord-305737-bnzd7b25	63	21	provided	provide	VBD
cord-305737-bnzd7b25	63	22	a	a	DT
cord-305737-bnzd7b25	63	23	structural	structural	JJ
cord-305737-bnzd7b25	63	24	explanation	explanation	NN
cord-305737-bnzd7b25	63	25	for	for	IN
cord-305737-bnzd7b25	63	26	detection	detection	NN
cord-305737-bnzd7b25	63	27	of	of	IN
cord-305737-bnzd7b25	63	28	this	this	DT
cord-305737-bnzd7b25	63	29	type	type	NN
cord-305737-bnzd7b25	63	30	of	of	IN
cord-305737-bnzd7b25	63	31	RNA	RNA	NNP
cord-305737-bnzd7b25	63	32	[	[	-LRB-
cord-305737-bnzd7b25	63	33	25	25	CD
cord-305737-bnzd7b25	63	34	,	,	,
cord-305737-bnzd7b25	63	35	26	26	CD
cord-305737-bnzd7b25	63	36	]	]	-RRB-
cord-305737-bnzd7b25	63	37	.	.	.
cord-305737-bnzd7b25	64	1	Much	much	JJ
cord-305737-bnzd7b25	64	2	progress	progress	NN
cord-305737-bnzd7b25	64	3	has	have	VBZ
cord-305737-bnzd7b25	64	4	been	be	VBN
cord-305737-bnzd7b25	64	5	made	make	VBN
cord-305737-bnzd7b25	64	6	in	in	IN
cord-305737-bnzd7b25	64	7	the	the	DT
cord-305737-bnzd7b25	64	8	last	last	JJ
cord-305737-bnzd7b25	64	9	two	two	CD
cord-305737-bnzd7b25	64	10	years	year	NNS
cord-305737-bnzd7b25	64	11	determining	determine	VBG
cord-305737-bnzd7b25	64	12	the	the	DT
cord-305737-bnzd7b25	64	13	structure	structure	NN
cord-305737-bnzd7b25	64	14	of	of	IN
cord-305737-bnzd7b25	64	15	the	the	DT
cord-305737-bnzd7b25	64	16	other	other	JJ
cord-305737-bnzd7b25	64	17	RIG	rig	NN
cord-305737-bnzd7b25	64	18	-	-	HYPH
cord-305737-bnzd7b25	64	19	I	-PRON-	PRP
cord-305737-bnzd7b25	64	20	domains	domain	NNS
cord-305737-bnzd7b25	64	21	and	and	CC
cord-305737-bnzd7b25	64	22	of	of	IN
cord-305737-bnzd7b25	64	23	the	the	DT
cord-305737-bnzd7b25	64	24	full	full	JJ
cord-305737-bnzd7b25	64	25	-	-	HYPH
cord-305737-bnzd7b25	64	26	length	length	NN
cord-305737-bnzd7b25	64	27	protein	protein	NN
cord-305737-bnzd7b25	64	28	[	[	-LRB-
cord-305737-bnzd7b25	64	29	22	22	CD
cord-305737-bnzd7b25	64	30	,	,	,
cord-305737-bnzd7b25	64	31	23	23	CD
cord-305737-bnzd7b25	64	32	]	]	-RRB-
cord-305737-bnzd7b25	64	33	.	.	.
cord-305737-bnzd7b25	65	1	Without	without	IN
cord-305737-bnzd7b25	65	2	an	an	DT
cord-305737-bnzd7b25	65	3	RNA	RNA	NNP
cord-305737-bnzd7b25	65	4	ligand	ligand	NN
cord-305737-bnzd7b25	65	5	,	,	,
cord-305737-bnzd7b25	65	6	full	full	JJ
cord-305737-bnzd7b25	65	7	-	-	HYPH
cord-305737-bnzd7b25	65	8	length	length	NN
cord-305737-bnzd7b25	65	9	RIG	rig	NN
cord-305737-bnzd7b25	65	10	-	-	:
cord-305737-bnzd7b25	65	11	I	-PRON-	PRP
cord-305737-bnzd7b25	65	12	adopts	adopt	VBZ
cord-305737-bnzd7b25	65	13	an	an	DT
cord-305737-bnzd7b25	65	14	autorepressed	autorepressed	JJ
cord-305737-bnzd7b25	65	15	state	state	NN
cord-305737-bnzd7b25	65	16	.	.	.
cord-305737-bnzd7b25	66	1	The	the	DT
cord-305737-bnzd7b25	66	2	helicase	helicase	NN
cord-305737-bnzd7b25	66	3	domain	domain	NN
cord-305737-bnzd7b25	66	4	is	be	VBZ
cord-305737-bnzd7b25	66	5	in	in	IN
cord-305737-bnzd7b25	66	6	an	an	DT
cord-305737-bnzd7b25	66	7	open	open	JJ
cord-305737-bnzd7b25	66	8	conformation	conformation	NN
cord-305737-bnzd7b25	66	9	,	,	,
cord-305737-bnzd7b25	66	10	flexibly	flexibly	RB
cord-305737-bnzd7b25	66	11	linked	link	VBN
cord-305737-bnzd7b25	66	12	to	to	IN
cord-305737-bnzd7b25	66	13	the	the	DT
cord-305737-bnzd7b25	66	14	CTD	CTD	NNP
cord-305737-bnzd7b25	66	15	and	and	CC
cord-305737-bnzd7b25	66	16	bound	bind	VBN
cord-305737-bnzd7b25	66	17	to	to	IN
cord-305737-bnzd7b25	66	18	the	the	DT
cord-305737-bnzd7b25	66	19	second	second	JJ
cord-305737-bnzd7b25	66	20	CARD	card	NN
cord-305737-bnzd7b25	66	21	[	[	-LRB-
cord-305737-bnzd7b25	66	22	28	28	CD
cord-305737-bnzd7b25	66	23	,	,	,
cord-305737-bnzd7b25	66	24	29,30	29,30	CD
cord-305737-bnzd7b25	66	25	]	]	-RRB-
cord-305737-bnzd7b25	67	1	(	(	-LRB-
cord-305737-bnzd7b25	67	2	Figure	figure	NN
cord-305737-bnzd7b25	67	3	2c	2c	NN
cord-305737-bnzd7b25	67	4	)	)	-RRB-
cord-305737-bnzd7b25	67	5	.	.	.
cord-305737-bnzd7b25	68	1	For	for	IN
cord-305737-bnzd7b25	68	2	downstream	downstream	JJ
cord-305737-bnzd7b25	68	3	signalling	signalling	NN
cord-305737-bnzd7b25	68	4	to	to	TO
cord-305737-bnzd7b25	68	5	occur	occur	VB
cord-305737-bnzd7b25	68	6	,	,	,
cord-305737-bnzd7b25	68	7	the	the	DT
cord-305737-bnzd7b25	68	8	CARDs	card	NNS
cord-305737-bnzd7b25	68	9	need	need	VBP
cord-305737-bnzd7b25	68	10	to	to	TO
cord-305737-bnzd7b25	68	11	be	be	VB
cord-305737-bnzd7b25	68	12	free	free	JJ
cord-305737-bnzd7b25	68	13	(	(	-LRB-
cord-305737-bnzd7b25	68	14	see	see	VB
cord-305737-bnzd7b25	68	15	below	below	RB
cord-305737-bnzd7b25	68	16	)	)	-RRB-
cord-305737-bnzd7b25	68	17	.	.	.
cord-305737-bnzd7b25	69	1	However	however	RB
cord-305737-bnzd7b25	69	2	,	,	,
cord-305737-bnzd7b25	69	3	the	the	DT
cord-305737-bnzd7b25	69	4	CARD2-helicase	CARD2-helicase	NNP
cord-305737-bnzd7b25	69	5	interaction	interaction	NN
cord-305737-bnzd7b25	69	6	observed	observe	VBN
cord-305737-bnzd7b25	69	7	in	in	IN
cord-305737-bnzd7b25	69	8	RNA	RNA	NNP
cord-305737-bnzd7b25	69	9	-	-	HYPH
cord-305737-bnzd7b25	69	10	free	free	JJ
cord-305737-bnzd7b25	69	11	RIG	rig	NN
cord-305737-bnzd7b25	69	12	-	-	:
cord-305737-bnzd7b25	69	13	I	-PRON-	PRP
cord-305737-bnzd7b25	69	14	constrains	constrain	VBZ
cord-305737-bnzd7b25	69	15	this	this	DT
cord-305737-bnzd7b25	69	16	freedom	freedom	NN
cord-305737-bnzd7b25	69	17	and	and	CC
cord-305737-bnzd7b25	69	18	thus	thus	RB
cord-305737-bnzd7b25	69	19	explains	explain	VBZ
cord-305737-bnzd7b25	69	20	autorepression	autorepression	NN
cord-305737-bnzd7b25	69	21	[	[	-LRB-
cord-305737-bnzd7b25	69	22	28	28	CD
cord-305737-bnzd7b25	69	23	,	,	,
cord-305737-bnzd7b25	69	24	30	30	CD
cord-305737-bnzd7b25	69	25	]	]	-RRB-
cord-305737-bnzd7b25	70	1	(	(	-LRB-
cord-305737-bnzd7b25	70	2	Figure	figure	NN
cord-305737-bnzd7b25	70	3	2c	2c	NN
cord-305737-bnzd7b25	70	4	)	)	-RRB-
cord-305737-bnzd7b25	70	5	.	.	.
cord-305737-bnzd7b25	71	1	Crystal	crystal	NN
cord-305737-bnzd7b25	71	2	structures	structure	NNS
cord-305737-bnzd7b25	71	3	of	of	IN
cord-305737-bnzd7b25	71	4	RIG	rig	NN
cord-305737-bnzd7b25	71	5	-	-	:
cord-305737-bnzd7b25	71	6	I	-PRON-	PRP
cord-305737-bnzd7b25	71	7	bound	bind	VBN
cord-305737-bnzd7b25	71	8	to	to	IN
cord-305737-bnzd7b25	71	9	short	short	JJ
cord-305737-bnzd7b25	71	10	doublestranded	doublestranded	JJ
cord-305737-bnzd7b25	71	11	RNAs	rna	NNS
cord-305737-bnzd7b25	71	12	[	[	-LRB-
cord-305737-bnzd7b25	71	13	28	28	CD
cord-305737-bnzd7b25	71	14	,	,	,
cord-305737-bnzd7b25	71	15	31	31	CD
cord-305737-bnzd7b25	71	16	,	,	,
cord-305737-bnzd7b25	71	17	32	32	CD
cord-305737-bnzd7b25	71	18	]	]	-RRB-
cord-305737-bnzd7b25	71	19	or	or	CC
cord-305737-bnzd7b25	71	20	to	to	IN
cord-305737-bnzd7b25	71	21	a	a	DT
cord-305737-bnzd7b25	71	22	5PPP	5ppp	CD
cord-305737-bnzd7b25	71	23	hairpin	hairpin	NN
cord-305737-bnzd7b25	71	24	single	single	JJ
cord-305737-bnzd7b25	71	25	-	-	HYPH
cord-305737-bnzd7b25	71	26	stranded	strand	VBN
cord-305737-bnzd7b25	71	27	RNA	RNA	NNP
cord-305737-bnzd7b25	71	28	[	[	-LRB-
cord-305737-bnzd7b25	71	29	33	33	CD
cord-305737-bnzd7b25	71	30	]	]	-RRB-
cord-305737-bnzd7b25	71	31	(	(	-LRB-
cord-305737-bnzd7b25	71	32	Figure	figure	NN
cord-305737-bnzd7b25	71	33	3b	3b	CD
cord-305737-bnzd7b25	71	34	)	)	-RRB-
cord-305737-bnzd7b25	71	35	reveal	reveal	VBP
cord-305737-bnzd7b25	71	36	how	how	WRB
cord-305737-bnzd7b25	71	37	the	the	DT
cord-305737-bnzd7b25	71	38	autorepressed	autorepressed	JJ
cord-305737-bnzd7b25	71	39	state	state	NN
cord-305737-bnzd7b25	71	40	is	be	VBZ
cord-305737-bnzd7b25	71	41	dismantled	dismantle	VBN
cord-305737-bnzd7b25	71	42	by	by	IN
cord-305737-bnzd7b25	71	43	structural	structural	JJ
cord-305737-bnzd7b25	71	44	rearrangement	rearrangement	NN
cord-305737-bnzd7b25	71	45	upon	upon	IN
cord-305737-bnzd7b25	71	46	RNA	RNA	NNP
cord-305737-bnzd7b25	71	47	agonist	agonist	NN
cord-305737-bnzd7b25	71	48	binding	binding	NN
cord-305737-bnzd7b25	71	49	.	.	.
cord-305737-bnzd7b25	72	1	The	the	DT
cord-305737-bnzd7b25	72	2	helicase	helicase	NN
cord-305737-bnzd7b25	72	3	adopts	adopt	VBZ
cord-305737-bnzd7b25	72	4	a	a	DT
cord-305737-bnzd7b25	72	5	closed	closed	JJ
cord-305737-bnzd7b25	72	6	conformation	conformation	NN
cord-305737-bnzd7b25	72	7	and	and	CC
cord-305737-bnzd7b25	72	8	completely	completely	RB
cord-305737-bnzd7b25	72	9	surrounds	surround	VBZ
cord-305737-bnzd7b25	72	10	the	the	DT
cord-305737-bnzd7b25	72	11	basepaired	basepaired	JJ
cord-305737-bnzd7b25	72	12	RNA	RNA	NNP
cord-305737-bnzd7b25	72	13	along	along	IN
cord-305737-bnzd7b25	72	14	its	-PRON-	PRP$
cord-305737-bnzd7b25	72	15	length	length	NN
cord-305737-bnzd7b25	72	16	,	,	,
cord-305737-bnzd7b25	72	17	while	while	IN
cord-305737-bnzd7b25	72	18	the	the	DT
cord-305737-bnzd7b25	72	19	CTD	CTD	NNP
cord-305737-bnzd7b25	72	20	caps	cap	VBZ
cord-305737-bnzd7b25	72	21	the	the	DT
cord-305737-bnzd7b25	72	22	5	5	CD
cord-305737-bnzd7b25	72	23	0end	0end	CD
cord-305737-bnzd7b25	72	24	by	by	IN
cord-305737-bnzd7b25	72	25	directly	directly	RB
cord-305737-bnzd7b25	72	26	interacting	interact	VBG
cord-305737-bnzd7b25	72	27	with	with	IN
cord-305737-bnzd7b25	72	28	the	the	DT
cord-305737-bnzd7b25	72	29	5PPP	5ppp	CD
cord-305737-bnzd7b25	72	30	and	and	CC
cord-305737-bnzd7b25	72	31	the	the	DT
cord-305737-bnzd7b25	72	32	first	first	JJ
cord-305737-bnzd7b25	72	33	few	few	JJ
cord-305737-bnzd7b25	72	34	nucleotides	nucleotide	NNS
cord-305737-bnzd7b25	72	35	[	[	-LRB-
cord-305737-bnzd7b25	72	36	28	28	CD
cord-305737-bnzd7b25	72	37	,	,	,
cord-305737-bnzd7b25	72	38	31	31	CD
cord-305737-bnzd7b25	72	39	,	,	,
cord-305737-bnzd7b25	72	40	32	32	CD
cord-305737-bnzd7b25	72	41	,	,	,
cord-305737-bnzd7b25	72	42	33	33	CD
cord-305737-bnzd7b25	72	43	]	]	-RRB-
cord-305737-bnzd7b25	73	1	(	(	-LRB-
cord-305737-bnzd7b25	73	2	Figures	figure	NNS
cord-305737-bnzd7b25	73	3	2d	2d	VBN
cord-305737-bnzd7b25	73	4	and	and	CC
cord-305737-bnzd7b25	73	5	3b	3b	CD
cord-305737-bnzd7b25	73	6	)	)	-RRB-
cord-305737-bnzd7b25	73	7	.	.	.
cord-305737-bnzd7b25	74	1	The	the	DT
cord-305737-bnzd7b25	74	2	binding	binding	NN
cord-305737-bnzd7b25	74	3	site	site	NN
cord-305737-bnzd7b25	74	4	for	for	IN
cord-305737-bnzd7b25	74	5	CARD2	CARD2	NNS
cord-305737-bnzd7b25	74	6	on	on	IN
cord-305737-bnzd7b25	74	7	the	the	DT
cord-305737-bnzd7b25	74	8	helicase	helicase	NN
cord-305737-bnzd7b25	74	9	domain	domain	NN
cord-305737-bnzd7b25	74	10	is	be	VBZ
cord-305737-bnzd7b25	74	11	now	now	RB
cord-305737-bnzd7b25	74	12	involved	involve	VBN
cord-305737-bnzd7b25	74	13	in	in	IN
cord-305737-bnzd7b25	74	14	RNA	RNA	NNP
cord-305737-bnzd7b25	74	15	binding	binding	NN
cord-305737-bnzd7b25	74	16	,	,	,
cord-305737-bnzd7b25	74	17	thus	thus	RB
cord-305737-bnzd7b25	74	18	allowing	allow	VBG
cord-305737-bnzd7b25	74	19	the	the	DT
cord-305737-bnzd7b25	74	20	CARDs	card	NNS
cord-305737-bnzd7b25	74	21	to	to	TO
cord-305737-bnzd7b25	74	22	be	be	VB
cord-305737-bnzd7b25	74	23	released	release	VBN
cord-305737-bnzd7b25	74	24	[	[	-LRB-
cord-305737-bnzd7b25	74	25	28	28	CD
cord-305737-bnzd7b25	74	26	,	,	,
cord-305737-bnzd7b25	74	27	31	31	CD
cord-305737-bnzd7b25	74	28	,	,	,
cord-305737-bnzd7b25	74	29	32	32	CD
cord-305737-bnzd7b25	74	30	,	,	,
cord-305737-bnzd7b25	74	31	33	33	CD
cord-305737-bnzd7b25	74	32	]	]	-RRB-
cord-305737-bnzd7b25	74	33	.	.	.
cord-305737-bnzd7b25	75	1	Furthermore	furthermore	RB
cord-305737-bnzd7b25	75	2	,	,	,
cord-305737-bnzd7b25	75	3	in	in	IN
cord-305737-bnzd7b25	75	4	the	the	DT
cord-305737-bnzd7b25	75	5	RNAbound	RNAbound	NNP
cord-305737-bnzd7b25	75	6	conformation	conformation	NN
cord-305737-bnzd7b25	75	7	,	,	,
cord-305737-bnzd7b25	75	8	a	a	DT
cord-305737-bnzd7b25	75	9	pincer	pincer	NN
cord-305737-bnzd7b25	75	10	domain	domain	NN
cord-305737-bnzd7b25	75	11	(	(	-LRB-
cord-305737-bnzd7b25	75	12	also	also	RB
cord-305737-bnzd7b25	75	13	called	call	VBN
cord-305737-bnzd7b25	75	14	bridging	bridge	VBG
cord-305737-bnzd7b25	75	15	helices	helix	NNS
cord-305737-bnzd7b25	75	16	)	)	-RRB-
cord-305737-bnzd7b25	75	17	places	place	VBZ
cord-305737-bnzd7b25	75	18	the	the	DT
cord-305737-bnzd7b25	75	19	CTD	CTD	NNP
cord-305737-bnzd7b25	75	20	in	in	IN
cord-305737-bnzd7b25	75	21	a	a	DT
cord-305737-bnzd7b25	75	22	position	position	NN
cord-305737-bnzd7b25	75	23	overlapping	overlap	VBG
cord-305737-bnzd7b25	75	24	with	with	IN
cord-305737-bnzd7b25	75	25	that	that	DT
cord-305737-bnzd7b25	75	26	previously	previously	RB
cord-305737-bnzd7b25	75	27	occupied	occupy	VBN
cord-305737-bnzd7b25	75	28	by	by	IN
cord-305737-bnzd7b25	75	29	CARD2	CARD2	NNS
cord-305737-bnzd7b25	75	30	[	[	-LRB-
cord-305737-bnzd7b25	75	31	28	28	CD
cord-305737-bnzd7b25	75	32	,	,	,
cord-305737-bnzd7b25	75	33	31	31	CD
cord-305737-bnzd7b25	75	34	,	,	,
cord-305737-bnzd7b25	75	35	32	32	CD
cord-305737-bnzd7b25	75	36	,	,	,
cord-305737-bnzd7b25	75	37	33	33	CD
cord-305737-bnzd7b25	75	38	]	]	-RRB-
cord-305737-bnzd7b25	75	39	(	(	-LRB-
cord-305737-bnzd7b25	75	40	Figure	figure	NN
cord-305737-bnzd7b25	75	41	2d	2d	CD
cord-305737-bnzd7b25	75	42	)	)	-RRB-
cord-305737-bnzd7b25	75	43	.	.	.
cord-305737-bnzd7b25	76	1	RNA	RNA	NNP
cord-305737-bnzd7b25	76	2	binding	binding	NN
cord-305737-bnzd7b25	76	3	is	be	VBZ
cord-305737-bnzd7b25	76	4	therefore	therefore	RB
cord-305737-bnzd7b25	76	5	predicted	predict	VBN
cord-305737-bnzd7b25	76	6	to	to	TO
cord-305737-bnzd7b25	76	7	push	push	VB
cord-305737-bnzd7b25	76	8	away	away	RB
cord-305737-bnzd7b25	76	9	the	the	DT
cord-305737-bnzd7b25	76	10	CARDs	card	NNS
cord-305737-bnzd7b25	76	11	.	.	.
cord-305737-bnzd7b25	77	1	This	this	DT
cord-305737-bnzd7b25	77	2	is	be	VBZ
cord-305737-bnzd7b25	77	3	likely	likely	JJ
cord-305737-bnzd7b25	77	4	to	to	TO
cord-305737-bnzd7b25	77	5	happen	happen	VB
cord-305737-bnzd7b25	77	6	in	in	IN
cord-305737-bnzd7b25	77	7	two	two	CD
cord-305737-bnzd7b25	77	8	steps	step	NNS
cord-305737-bnzd7b25	77	9	:	:	:
cord-305737-bnzd7b25	77	10	first	first	RB
cord-305737-bnzd7b25	77	11	,	,	,
cord-305737-bnzd7b25	77	12	the	the	DT
cord-305737-bnzd7b25	77	13	CTD	CTD	NNP
cord-305737-bnzd7b25	77	14	recognizes	recognize	VBZ
cord-305737-bnzd7b25	77	15	the	the	DT
cord-305737-bnzd7b25	77	16	5PPP	5ppp	CD
cord-305737-bnzd7b25	77	17	group	group	NN
cord-305737-bnzd7b25	77	18	and	and	CC
cord-305737-bnzd7b25	77	19	,	,	,
cord-305737-bnzd7b25	77	20	second	second	RB
cord-305737-bnzd7b25	77	21	,	,	,
cord-305737-bnzd7b25	77	22	the	the	DT
cord-305737-bnzd7b25	77	23	helicase	helicase	NN
cord-305737-bnzd7b25	77	24	domain	domain	NN
cord-305737-bnzd7b25	77	25	binds	bind	VBZ
cord-305737-bnzd7b25	77	26	to	to	IN
cord-305737-bnzd7b25	77	27	the	the	DT
cord-305737-bnzd7b25	77	28	basepaired	basepaired	JJ
cord-305737-bnzd7b25	77	29	region	region	NN
cord-305737-bnzd7b25	77	30	(	(	-LRB-
cord-305737-bnzd7b25	77	31	Figure	Figure	NNP
cord-305737-bnzd7b25	77	32	2c	2c	NN
cord-305737-bnzd7b25	77	33	,	,	,
cord-305737-bnzd7b25	77	34	d	d	NN
cord-305737-bnzd7b25	77	35	)	)	-RRB-
cord-305737-bnzd7b25	78	1	[	[	-LRB-
cord-305737-bnzd7b25	78	2	22	22	CD
cord-305737-bnzd7b25	78	3	,	,	,
cord-305737-bnzd7b25	78	4	23	23	CD
cord-305737-bnzd7b25	78	5	]	]	-RRB-
cord-305737-bnzd7b25	78	6	.	.	.
cord-305737-bnzd7b25	79	1	The	the	DT
cord-305737-bnzd7b25	79	2	hydrolysis	hydrolysis	NN
cord-305737-bnzd7b25	79	3	of	of	IN
cord-305737-bnzd7b25	79	4	ATP	ATP	NNP
cord-305737-bnzd7b25	79	5	is	be	VBZ
cord-305737-bnzd7b25	79	6	thought	think	VBN
cord-305737-bnzd7b25	79	7	to	to	TO
cord-305737-bnzd7b25	79	8	tighten	tighten	VB
cord-305737-bnzd7b25	79	9	the	the	DT
cord-305737-bnzd7b25	79	10	helicase	helicase	NN
cord-305737-bnzd7b25	79	11	domain	domain	NN
cord-305737-bnzd7b25	79	12	around	around	IN
cord-305737-bnzd7b25	79	13	the	the	DT
cord-305737-bnzd7b25	79	14	RNA	RNA	NNP
cord-305737-bnzd7b25	79	15	,	,	,
cord-305737-bnzd7b25	79	16	further	further	RB
cord-305737-bnzd7b25	79	17	favouring	favour	VBG
cord-305737-bnzd7b25	79	18	CARD	card	NN
cord-305737-bnzd7b25	79	19	release	release	NN
cord-305737-bnzd7b25	79	20	[	[	-LRB-
cord-305737-bnzd7b25	79	21	33	33	CD
cord-305737-bnzd7b25	79	22	]	]	-RRB-
cord-305737-bnzd7b25	79	23	.	.	.
cord-305737-bnzd7b25	80	1	MDA5	MDA5	NNP
cord-305737-bnzd7b25	80	2	is	be	VBZ
cord-305737-bnzd7b25	80	3	another	another	DT
cord-305737-bnzd7b25	80	4	RLR	RLR	NNP
cord-305737-bnzd7b25	80	5	.	.	.
cord-305737-bnzd7b25	81	1	A	a	DT
cord-305737-bnzd7b25	81	2	recent	recent	JJ
cord-305737-bnzd7b25	81	3	crystal	crystal	NN
cord-305737-bnzd7b25	81	4	structure	structure	NN
cord-305737-bnzd7b25	81	5	of	of	IN
cord-305737-bnzd7b25	81	6	the	the	DT
cord-305737-bnzd7b25	81	7	MDA5	mda5	JJ
cord-305737-bnzd7b25	81	8	helicase	helicase	NN
cord-305737-bnzd7b25	81	9	domain	domain	NN
cord-305737-bnzd7b25	81	10	and	and	CC
cord-305737-bnzd7b25	81	11	CTD	CTD	NNP
cord-305737-bnzd7b25	81	12	in	in	IN
cord-305737-bnzd7b25	81	13	complex	complex	NN
cord-305737-bnzd7b25	81	14	with	with	IN
cord-305737-bnzd7b25	81	15	double	double	RB
cord-305737-bnzd7b25	81	16	-	-	HYPH
cord-305737-bnzd7b25	81	17	stranded	strand	VBN
cord-305737-bnzd7b25	81	18	RNA	RNA	NNP
cord-305737-bnzd7b25	81	19	shows	show	VBZ
cord-305737-bnzd7b25	81	20	that	that	IN
cord-305737-bnzd7b25	81	21	these	these	DT
cord-305737-bnzd7b25	81	22	domains	domain	NNS
cord-305737-bnzd7b25	81	23	form	form	VBP
cord-305737-bnzd7b25	81	24	a	a	DT
cord-305737-bnzd7b25	81	25	ring	ring	NN
cord-305737-bnzd7b25	81	26	around	around	IN
cord-305737-bnzd7b25	81	27	the	the	DT
cord-305737-bnzd7b25	81	28	RNA	RNA	NNP
cord-305737-bnzd7b25	81	29	,	,	,
cord-305737-bnzd7b25	81	30	leaving	leave	VBG
cord-305737-bnzd7b25	81	31	both	both	DT
cord-305737-bnzd7b25	81	32	ends	end	NNS
cord-305737-bnzd7b25	81	33	free	free	JJ
cord-305737-bnzd7b25	81	34	to	to	TO
cord-305737-bnzd7b25	81	35	extend	extend	VB
cord-305737-bnzd7b25	81	36	[	[	-LRB-
cord-305737-bnzd7b25	81	37	34	34	CD
cord-305737-bnzd7b25	81	38	]	]	-RRB-
cord-305737-bnzd7b25	81	39	.	.	.
cord-305737-bnzd7b25	82	1	This	this	DT
cord-305737-bnzd7b25	82	2	is	be	VBZ
cord-305737-bnzd7b25	82	3	in	in	IN
cord-305737-bnzd7b25	82	4	contrast	contrast	NN
cord-305737-bnzd7b25	82	5	to	to	IN
cord-305737-bnzd7b25	82	6	the	the	DT
cord-305737-bnzd7b25	82	7	equivalent	equivalent	JJ
cord-305737-bnzd7b25	82	8	domains	domain	NNS
cord-305737-bnzd7b25	82	9	in	in	IN
cord-305737-bnzd7b25	82	10	RIG	rig	NN
cord-305737-bnzd7b25	82	11	-	-	:
cord-305737-bnzd7b25	82	12	I	-PRON-	PRP
cord-305737-bnzd7b25	82	13	that	that	WDT
cord-305737-bnzd7b25	82	14	cap	cap	VBP
cord-305737-bnzd7b25	82	15	one	one	CD
cord-305737-bnzd7b25	82	16	end	end	NN
cord-305737-bnzd7b25	82	17	of	of	IN
cord-305737-bnzd7b25	82	18	5PPP	5ppp	CD
cord-305737-bnzd7b25	82	19	base	base	NN
cord-305737-bnzd7b25	82	20	-	-	HYPH
cord-305737-bnzd7b25	82	21	paired	pair	VBN
cord-305737-bnzd7b25	82	22	RNA	RNA	NNP
cord-305737-bnzd7b25	82	23	,	,	,
cord-305737-bnzd7b25	82	24	due	due	IN
cord-305737-bnzd7b25	82	25	to	to	IN
cord-305737-bnzd7b25	82	26	tilting	tilt	VBG
cord-305737-bnzd7b25	82	27	of	of	IN
cord-305737-bnzd7b25	82	28	the	the	DT
cord-305737-bnzd7b25	82	29	RIG	rig	NN
cord-305737-bnzd7b25	82	30	-	-	:
cord-305737-bnzd7b25	82	31	I	-PRON-	PRP
cord-305737-bnzd7b25	82	32	CTD	CTD	NNP
cord-305737-bnzd7b25	82	33	towards	towards	IN
cord-305737-bnzd7b25	82	34	the	the	DT
cord-305737-bnzd7b25	82	35	RNA	RNA	NNP
cord-305737-bnzd7b25	82	36	[	[	-LRB-
cord-305737-bnzd7b25	82	37	34	34	CD
cord-305737-bnzd7b25	82	38	]	]	-RRB-
cord-305737-bnzd7b25	82	39	.	.	.
cord-305737-bnzd7b25	83	1	This	this	DT
cord-305737-bnzd7b25	83	2	structural	structural	JJ
cord-305737-bnzd7b25	83	3	difference	difference	NN
cord-305737-bnzd7b25	83	4	,	,	,
cord-305737-bnzd7b25	83	5	together	together	RB
cord-305737-bnzd7b25	83	6	with	with	IN
cord-305737-bnzd7b25	83	7	the	the	DT
cord-305737-bnzd7b25	83	8	absence	absence	NN
cord-305737-bnzd7b25	83	9	of	of	IN
cord-305737-bnzd7b25	83	10	a	a	DT
cord-305737-bnzd7b25	83	11	5PPP	5ppp	CD
cord-305737-bnzd7b25	83	12	-	-	HYPH
cord-305737-bnzd7b25	83	13	binding	bind	VBG
cord-305737-bnzd7b25	83	14	pocket	pocket	NN
cord-305737-bnzd7b25	83	15	in	in	IN
cord-305737-bnzd7b25	83	16	the	the	DT
cord-305737-bnzd7b25	83	17	CTD	CTD	NNP
cord-305737-bnzd7b25	83	18	of	of	IN
cord-305737-bnzd7b25	83	19	MDA5	MDA5	NNP
cord-305737-bnzd7b25	83	20	[	[	-LRB-
cord-305737-bnzd7b25	83	21	25,34	25,34	CD
cord-305737-bnzd7b25	83	22	,	,	,
cord-305737-bnzd7b25	83	23	35,36	35,36	CD
cord-305737-bnzd7b25	83	24	]	]	-RRB-
cord-305737-bnzd7b25	83	25	,	,	,
cord-305737-bnzd7b25	83	26	may	may	MD
cord-305737-bnzd7b25	83	27	explain	explain	VB
cord-305737-bnzd7b25	83	28	why	why	WRB
cord-305737-bnzd7b25	83	29	the	the	DT
cord-305737-bnzd7b25	83	30	two	two	CD
cord-305737-bnzd7b25	83	31	RLRs	rlr	NNS
cord-305737-bnzd7b25	83	32	recognize	recognize	VBP
cord-305737-bnzd7b25	83	33	different	different	JJ
cord-305737-bnzd7b25	83	34	types	type	NNS
cord-305737-bnzd7b25	83	35	of	of	IN
cord-305737-bnzd7b25	83	36	RNA	RNA	NNP
cord-305737-bnzd7b25	83	37	and	and	CC
cord-305737-bnzd7b25	83	38	mediate	mediate	VB
cord-305737-bnzd7b25	83	39	IFN	IFN	NNP
cord-305737-bnzd7b25	83	40	responses	response	NNS
cord-305737-bnzd7b25	83	41	to	to	IN
cord-305737-bnzd7b25	83	42	different	different	JJ
cord-305737-bnzd7b25	83	43	viruses	virus	NNS
cord-305737-bnzd7b25	83	44	[	[	-LRB-
cord-305737-bnzd7b25	83	45	37	37	CD
cord-305737-bnzd7b25	83	46	,	,	,
cord-305737-bnzd7b25	83	47	38	38	CD
cord-305737-bnzd7b25	83	48	]	]	-RRB-
cord-305737-bnzd7b25	83	49	.	.	.
cord-305737-bnzd7b25	84	1	Upon	upon	IN
cord-305737-bnzd7b25	84	2	RNA	RNA	NNP
cord-305737-bnzd7b25	84	3	agonist	agonist	NN
cord-305737-bnzd7b25	84	4	binding	binding	NN
cord-305737-bnzd7b25	84	5	and	and	CC
cord-305737-bnzd7b25	84	6	CARD	card	NN
cord-305737-bnzd7b25	84	7	exposure	exposure	NN
cord-305737-bnzd7b25	84	8	,	,	,
cord-305737-bnzd7b25	84	9	RIG	rig	NN
cord-305737-bnzd7b25	84	10	-	-	:
cord-305737-bnzd7b25	84	11	I	-PRON-	PRP
cord-305737-bnzd7b25	84	12	initiates	initiate	VBZ
cord-305737-bnzd7b25	84	13	a	a	DT
cord-305737-bnzd7b25	84	14	signal	signal	NN
cord-305737-bnzd7b25	84	15	transduction	transduction	NN
cord-305737-bnzd7b25	84	16	cascade	cascade	NN
cord-305737-bnzd7b25	84	17	that	that	WDT
cord-305737-bnzd7b25	84	18	ultimately	ultimately	RB
cord-305737-bnzd7b25	84	19	results	result	VBZ
cord-305737-bnzd7b25	84	20	in	in	IN
cord-305737-bnzd7b25	84	21	IFN	IFN	NNP
cord-305737-bnzd7b25	84	22	gene	gene	NN
cord-305737-bnzd7b25	84	23	transcription	transcription	NN
cord-305737-bnzd7b25	84	24	[	[	-LRB-
cord-305737-bnzd7b25	84	25	3	3	CD
cord-305737-bnzd7b25	84	26	]	]	-RRB-
cord-305737-bnzd7b25	84	27	.	.	.
cord-305737-bnzd7b25	85	1	MAVS	MAVS	NNP
cord-305737-bnzd7b25	85	2	is	be	VBZ
cord-305737-bnzd7b25	85	3	the	the	DT
cord-305737-bnzd7b25	85	4	RIG	rig	NN
cord-305737-bnzd7b25	85	5	-	-	:
cord-305737-bnzd7b25	85	6	I	I	NNP
cord-305737-bnzd7b25	85	7	and	and	CC
cord-305737-bnzd7b25	85	8	MDA5	mda5	JJ
cord-305737-bnzd7b25	85	9	proximal	proximal	JJ
cord-305737-bnzd7b25	85	10	adaptor	adaptor	NN
cord-305737-bnzd7b25	85	11	protein	protein	NN
cord-305737-bnzd7b25	85	12	.	.	.
cord-305737-bnzd7b25	86	1	It	-PRON-	PRP
cord-305737-bnzd7b25	86	2	mediates	mediate	VBZ
cord-305737-bnzd7b25	86	3	activation	activation	NN
cord-305737-bnzd7b25	86	4	of	of	IN
cord-305737-bnzd7b25	86	5	kinases	kinase	NNS
cord-305737-bnzd7b25	86	6	such	such	JJ
cord-305737-bnzd7b25	86	7	as	as	IN
cord-305737-bnzd7b25	86	8	TBK1	TBK1	NNP
cord-305737-bnzd7b25	86	9	,	,	,
cord-305737-bnzd7b25	86	10	which	which	WDT
cord-305737-bnzd7b25	86	11	phosphorylate	phosphorylate	VBP
cord-305737-bnzd7b25	86	12	transcription	transcription	NN
cord-305737-bnzd7b25	86	13	factors	factor	NNS
cord-305737-bnzd7b25	86	14	including	include	VBG
cord-305737-bnzd7b25	86	15	IRF3	IRF3	NNP
cord-305737-bnzd7b25	86	16	that	that	WDT
cord-305737-bnzd7b25	86	17	then	then	RB
cord-305737-bnzd7b25	86	18	translocate	translocate	VBP
cord-305737-bnzd7b25	86	19	to	to	IN
cord-305737-bnzd7b25	86	20	the	the	DT
cord-305737-bnzd7b25	86	21	cell	cell	NN
cord-305737-bnzd7b25	86	22	nucleus	nucleus	NN
cord-305737-bnzd7b25	86	23	to	to	TO
cord-305737-bnzd7b25	86	24	trigger	trigger	VB
cord-305737-bnzd7b25	86	25	transcription	transcription	NN
cord-305737-bnzd7b25	86	26	of	of	IN
cord-305737-bnzd7b25	86	27	IFN	IFN	NNP
cord-305737-bnzd7b25	86	28	genes	gene	NNS
cord-305737-bnzd7b25	86	29	(	(	-LRB-
cord-305737-bnzd7b25	86	30	Figure	figure	NN
cord-305737-bnzd7b25	86	31	1	1	CD
cord-305737-bnzd7b25	86	32	)	)	-RRB-
cord-305737-bnzd7b25	86	33	.	.	.
cord-305737-bnzd7b25	87	1	MAVS	MAVS	NNP
cord-305737-bnzd7b25	87	2	has	have	VBZ
cord-305737-bnzd7b25	87	3	a	a	DT
cord-305737-bnzd7b25	87	4	C	c	NN
cord-305737-bnzd7b25	87	5	-	-	HYPH
cord-305737-bnzd7b25	87	6	terminal	terminal	NN
cord-305737-bnzd7b25	87	7	transmembrane	transmembrane	NN
cord-305737-bnzd7b25	87	8	domain	domain	NN
cord-305737-bnzd7b25	87	9	and	and	CC
cord-305737-bnzd7b25	87	10	a	a	DT
cord-305737-bnzd7b25	87	11	single	single	JJ
cord-305737-bnzd7b25	87	12	N	n	CD
cord-305737-bnzd7b25	87	13	-	-	HYPH
cord-305737-bnzd7b25	87	14	terminal	terminal	NN
cord-305737-bnzd7b25	87	15	CARD	card	NN
cord-305737-bnzd7b25	87	16	,	,	,
cord-305737-bnzd7b25	87	17	which	which	WDT
cord-305737-bnzd7b25	87	18	engages	engage	VBZ
cord-305737-bnzd7b25	87	19	in	in	IN
cord-305737-bnzd7b25	87	20	CARD	card	NN
cord-305737-bnzd7b25	87	21	-	-	HYPH
cord-305737-bnzd7b25	87	22	CARD	card	NN
cord-305737-bnzd7b25	87	23	interactions	interaction	NNS
cord-305737-bnzd7b25	87	24	with	with	IN
cord-305737-bnzd7b25	88	1	RIG	rig	NN
cord-305737-bnzd7b25	88	2	-	-	HYPH
cord-305737-bnzd7b25	88	3	I.	i.	NN
cord-305737-bnzd7b25	88	4	This	this	DT
cord-305737-bnzd7b25	88	5	interaction	interaction	NN
cord-305737-bnzd7b25	88	6	requires	require	VBZ
cord-305737-bnzd7b25	88	7	binding	bind	VBG
cord-305737-bnzd7b25	88	8	to	to	IN
cord-305737-bnzd7b25	88	9	K63-linked	K63-linked	NNP
cord-305737-bnzd7b25	88	10	polyubiquitin	polyubiquitin	NNP
cord-305737-bnzd7b25	88	11	chains	chain	NNS
cord-305737-bnzd7b25	88	12	generated	generate	VBN
cord-305737-bnzd7b25	88	13	by	by	IN
cord-305737-bnzd7b25	88	14	the	the	DT
cord-305737-bnzd7b25	88	15	ubiquitin	ubiquitin	NN
cord-305737-bnzd7b25	88	16	ligase	ligase	NN
cord-305737-bnzd7b25	89	1	TRIM25	trim25	NN
cord-305737-bnzd7b25	90	1	(	(	-LRB-
cord-305737-bnzd7b25	90	2	Figure	figure	NN
cord-305737-bnzd7b25	90	3	2e	2e	CD
cord-305737-bnzd7b25	90	4	)	)	-RRB-
cord-305737-bnzd7b25	91	1	[	[	-LRB-
cord-305737-bnzd7b25	91	2	21	21	CD
cord-305737-bnzd7b25	91	3	,	,	,
cord-305737-bnzd7b25	91	4	39	39	CD
cord-305737-bnzd7b25	91	5	,	,	,
cord-305737-bnzd7b25	91	6	40	40	CD
cord-305737-bnzd7b25	91	7	]	]	-RRB-
cord-305737-bnzd7b25	91	8	.	.	.
cord-305737-bnzd7b25	92	1	One	one	CD
cord-305737-bnzd7b25	92	2	study	study	NN
cord-305737-bnzd7b25	92	3	suggests	suggest	VBZ
cord-305737-bnzd7b25	92	4	that	that	IN
cord-305737-bnzd7b25	92	5	TRIM25	TRIM25	NNP
cord-305737-bnzd7b25	92	6	mediates	mediate	VBZ
cord-305737-bnzd7b25	92	7	covalent	covalent	JJ
cord-305737-bnzd7b25	92	8	ubiquitylation	ubiquitylation	NN
cord-305737-bnzd7b25	92	9	of	of	IN
cord-305737-bnzd7b25	92	10	RIG	rig	NN
cord-305737-bnzd7b25	92	11	-	-	:
cord-305737-bnzd7b25	92	12	I	-PRON-	PRP
cord-305737-bnzd7b25	92	13	at	at	IN
cord-305737-bnzd7b25	92	14	lysine	lysine	NN
cord-305737-bnzd7b25	92	15	172	172	CD
cord-305737-bnzd7b25	92	16	in	in	IN
cord-305737-bnzd7b25	92	17	the	the	DT
cord-305737-bnzd7b25	92	18	second	second	JJ
cord-305737-bnzd7b25	92	19	RIG	rig	NN
cord-305737-bnzd7b25	92	20	-	-	HYPH
cord-305737-bnzd7b25	92	21	I	-PRON-	PRP
cord-305737-bnzd7b25	92	22	CARD	card	VBP
cord-305737-bnzd7b25	92	23	[	[	-LRB-
cord-305737-bnzd7b25	92	24	39	39	CD
cord-305737-bnzd7b25	92	25	]	]	-RRB-
cord-305737-bnzd7b25	92	26	.	.	.
cord-305737-bnzd7b25	93	1	A	a	DT
cord-305737-bnzd7b25	93	2	different	different	JJ
cord-305737-bnzd7b25	93	3	study	study	NN
cord-305737-bnzd7b25	93	4	indicates	indicate	VBZ
cord-305737-bnzd7b25	93	5	that	that	IN
cord-305737-bnzd7b25	93	6	the	the	DT
cord-305737-bnzd7b25	93	7	same	same	JJ
cord-305737-bnzd7b25	93	8	lysine	lysine	NN
cord-305737-bnzd7b25	93	9	binds	bind	VBZ
cord-305737-bnzd7b25	93	10	non	non	NNS
cord-305737-bnzd7b25	93	11	-	-	NN
cord-305737-bnzd7b25	93	12	covalently	covalently	RB
cord-305737-bnzd7b25	93	13	to	to	IN
cord-305737-bnzd7b25	93	14	TRIM25generated	trim25generated	JJ
cord-305737-bnzd7b25	93	15	free	free	JJ
cord-305737-bnzd7b25	93	16	ubiquitin	ubiquitin	NN
cord-305737-bnzd7b25	93	17	chains	chain	NNS
cord-305737-bnzd7b25	93	18	[	[	-LRB-
cord-305737-bnzd7b25	93	19	21	21	CD
cord-305737-bnzd7b25	93	20	]	]	-RRB-
cord-305737-bnzd7b25	93	21	.	.	.
cord-305737-bnzd7b25	94	1	CARD	card	NN
cord-305737-bnzd7b25	94	2	-	-	HYPH
cord-305737-bnzd7b25	94	3	associated	associate	VBN
cord-305737-bnzd7b25	94	4	ubiquitin	ubiquitin	NN
cord-305737-bnzd7b25	94	5	chains	chain	NNS
cord-305737-bnzd7b25	94	6	are	be	VBP
cord-305737-bnzd7b25	94	7	key	key	JJ
cord-305737-bnzd7b25	94	8	for	for	IN
cord-305737-bnzd7b25	94	9	signalling	signal	VBG
cord-305737-bnzd7b25	94	10	as	as	IN
cord-305737-bnzd7b25	94	11	they	-PRON-	PRP
cord-305737-bnzd7b25	94	12	trigger	trigger	VBP
cord-305737-bnzd7b25	94	13	formation	formation	NN
cord-305737-bnzd7b25	94	14	of	of	IN
cord-305737-bnzd7b25	94	15	RIG	rig	NN
cord-305737-bnzd7b25	94	16	-	-	:
cord-305737-bnzd7b25	94	17	I	i	NN
cord-305737-bnzd7b25	94	18	tetramers	tetramer	NNS
cord-305737-bnzd7b25	94	19	(	(	-LRB-
cord-305737-bnzd7b25	94	20	Figure	Figure	NNP
cord-305737-bnzd7b25	94	21	2f	2f	NNP
cord-305737-bnzd7b25	94	22	)	)	-RRB-
cord-305737-bnzd7b25	94	23	[	[	-LRB-
cord-305737-bnzd7b25	94	24	40	40	CD
cord-305737-bnzd7b25	94	25	]	]	-RRB-
cord-305737-bnzd7b25	94	26	.	.	.
cord-305737-bnzd7b25	95	1	The	the	DT
cord-305737-bnzd7b25	95	2	resulting	result	VBG
cord-305737-bnzd7b25	95	3	CARD	card	NN
cord-305737-bnzd7b25	95	4	clusters	cluster	NNS
cord-305737-bnzd7b25	95	5	recruit	recruit	VBP
cord-305737-bnzd7b25	95	6	multiple	multiple	JJ
cord-305737-bnzd7b25	95	7	MAVS	MAVS	NNP
cord-305737-bnzd7b25	95	8	molecules	molecule	NNS
cord-305737-bnzd7b25	95	9	[	[	-LRB-
cord-305737-bnzd7b25	95	10	40	40	CD
cord-305737-bnzd7b25	95	11	,	,	,
cord-305737-bnzd7b25	95	12	41	41	CD
cord-305737-bnzd7b25	95	13	]	]	-RRB-
cord-305737-bnzd7b25	95	14	.	.	.
cord-305737-bnzd7b25	96	1	Surprisingly	surprisingly	RB
cord-305737-bnzd7b25	96	2	,	,	,
cord-305737-bnzd7b25	96	3	the	the	DT
cord-305737-bnzd7b25	96	4	stoichiometry	stoichiometry	NN
cord-305737-bnzd7b25	96	5	of	of	IN
cord-305737-bnzd7b25	96	6	this	this	DT
cord-305737-bnzd7b25	96	7	reaction	reaction	NN
cord-305737-bnzd7b25	96	8	reveals	reveal	VBZ
cord-305737-bnzd7b25	96	9	signal	signal	NN
cord-305737-bnzd7b25	96	10	amplification	amplification	NN
cord-305737-bnzd7b25	96	11	through	through	IN
cord-305737-bnzd7b25	96	12	self	self	NN
cord-305737-bnzd7b25	96	13	-	-	HYPH
cord-305737-bnzd7b25	96	14	propagation	propagation	NN
cord-305737-bnzd7b25	96	15	(	(	-LRB-
cord-305737-bnzd7b25	96	16	Figure	Figure	NNP
cord-305737-bnzd7b25	96	17	2f	2f	NNP
cord-305737-bnzd7b25	96	18	,	,	,
cord-305737-bnzd7b25	96	19	g	g	NNP
cord-305737-bnzd7b25	96	20	)	)	-RRB-
cord-305737-bnzd7b25	96	21	.	.	.
cord-305737-bnzd7b25	97	1	MAVS	MAVS	NNP
cord-305737-bnzd7b25	97	2	forms	form	VBZ
cord-305737-bnzd7b25	97	3	fibrils	fibril	NNS
cord-305737-bnzd7b25	97	4	that	that	WDT
cord-305737-bnzd7b25	97	5	convert	convert	VBP
cord-305737-bnzd7b25	97	6	additional	additional	JJ
cord-305737-bnzd7b25	97	7	MAVS	MAVS	NNP
cord-305737-bnzd7b25	97	8	molecules	molecule	NNS
cord-305737-bnzd7b25	97	9	into	into	IN
cord-305737-bnzd7b25	97	10	the	the	DT
cord-305737-bnzd7b25	97	11	fibrillar	fibrillar	NNP
cord-305737-bnzd7b25	97	12	conformation	conformation	NN
cord-305737-bnzd7b25	97	13	,	,	,
cord-305737-bnzd7b25	97	14	in	in	IN
cord-305737-bnzd7b25	97	15	a	a	DT
cord-305737-bnzd7b25	97	16	self	self	NN
cord-305737-bnzd7b25	97	17	-	-	HYPH
cord-305737-bnzd7b25	97	18	amplification	amplification	NN
cord-305737-bnzd7b25	97	19	mode	mode	NN
cord-305737-bnzd7b25	97	20	reminiscent	reminiscent	JJ
cord-305737-bnzd7b25	97	21	of	of	IN
cord-305737-bnzd7b25	97	22	prions	prion	NNS
cord-305737-bnzd7b25	97	23	[	[	-LRB-
cord-305737-bnzd7b25	97	24	41	41	CD
cord-305737-bnzd7b25	97	25	]	]	-RRB-
cord-305737-bnzd7b25	97	26	.	.	.
cord-305737-bnzd7b25	98	1	The	the	DT
cord-305737-bnzd7b25	98	2	MAVS	MAVS	NNP
cord-305737-bnzd7b25	98	3	fibrils	fibril	NNS
cord-305737-bnzd7b25	98	4	in	in	IN
cord-305737-bnzd7b25	98	5	turn	turn	NN
cord-305737-bnzd7b25	98	6	mediate	mediate	JJ
cord-305737-bnzd7b25	98	7	activation	activation	NN
cord-305737-bnzd7b25	98	8	of	of	IN
cord-305737-bnzd7b25	98	9	TBK1	TBK1	NNP
cord-305737-bnzd7b25	99	1	[	[	-LRB-
cord-305737-bnzd7b25	99	2	41	41	CD
cord-305737-bnzd7b25	99	3	]	]	-RRB-
cord-305737-bnzd7b25	100	1	(	(	-LRB-
cord-305737-bnzd7b25	100	2	Figure	figure	NN
cord-305737-bnzd7b25	100	3	2	2	CD
cord-305737-bnzd7b25	100	4	g	g	NN
cord-305737-bnzd7b25	100	5	)	)	-RRB-
cord-305737-bnzd7b25	100	6	.	.	.
cord-305737-bnzd7b25	101	1	A	a	DT
cord-305737-bnzd7b25	101	2	subsequent	subsequent	JJ
cord-305737-bnzd7b25	101	3	study	study	NN
cord-305737-bnzd7b25	101	4	confirmed	confirm	VBD
cord-305737-bnzd7b25	101	5	the	the	DT
cord-305737-bnzd7b25	101	6	prion	prion	NN
cord-305737-bnzd7b25	101	7	-	-	HYPH
cord-305737-bnzd7b25	101	8	like	like	JJ
cord-305737-bnzd7b25	101	9	behaviour	behaviour	NN
cord-305737-bnzd7b25	101	10	of	of	IN
cord-305737-bnzd7b25	101	11	MAVS	MAVS	NNPS
cord-305737-bnzd7b25	101	12	and	and	CC
cord-305737-bnzd7b25	101	13	showed	show	VBD
cord-305737-bnzd7b25	101	14	that	that	IN
cord-305737-bnzd7b25	101	15	it	-PRON-	PRP
cord-305737-bnzd7b25	101	16	can	can	MD
cord-305737-bnzd7b25	101	17	also	also	RB
cord-305737-bnzd7b25	101	18	be	be	VB
cord-305737-bnzd7b25	101	19	triggered	trigger	VBN
cord-305737-bnzd7b25	101	20	by	by	IN
cord-305737-bnzd7b25	101	21	the	the	DT
cord-305737-bnzd7b25	101	22	CARDs	card	NNS
cord-305737-bnzd7b25	101	23	of	of	IN
cord-305737-bnzd7b25	101	24	MDA5	MDA5	NNP
cord-305737-bnzd7b25	101	25	[	[	-LRB-
cord-305737-bnzd7b25	101	26	34	34	CD
cord-305737-bnzd7b25	101	27	]	]	-RRB-
cord-305737-bnzd7b25	101	28	.	.	.
cord-305737-bnzd7b25	102	1	Selfpropagation	Selfpropagation	NNP
cord-305737-bnzd7b25	102	2	allows	allow	VBZ
cord-305737-bnzd7b25	102	3	for	for	IN
cord-305737-bnzd7b25	102	4	sensitive	sensitive	JJ
cord-305737-bnzd7b25	102	5	detection	detection	NN
cord-305737-bnzd7b25	102	6	of	of	IN
cord-305737-bnzd7b25	102	7	minute	minute	NN
cord-305737-bnzd7b25	102	8	amounts	amount	NNS
cord-305737-bnzd7b25	102	9	of	of	IN
cord-305737-bnzd7b25	102	10	viral	viral	JJ
cord-305737-bnzd7b25	102	11	RNA	RNA	NNP
cord-305737-bnzd7b25	102	12	:	:	:
cord-305737-bnzd7b25	102	13	it	-PRON-	PRP
cord-305737-bnzd7b25	102	14	has	have	VBZ
cord-305737-bnzd7b25	102	15	been	be	VBN
cord-305737-bnzd7b25	102	16	estimated	estimate	VBN
cord-305737-bnzd7b25	102	17	that	that	IN
cord-305737-bnzd7b25	102	18	20	20	CD
cord-305737-bnzd7b25	102	19	molecules	molecule	NNS
cord-305737-bnzd7b25	102	20	of	of	IN
cord-305737-bnzd7b25	102	21	5PPP	5ppp	CD
cord-305737-bnzd7b25	102	22	RNA	RNA	NNP
cord-305737-bnzd7b25	102	23	are	be	VBP
cord-305737-bnzd7b25	102	24	sufficient	sufficient	JJ
cord-305737-bnzd7b25	102	25	to	to	TO
cord-305737-bnzd7b25	102	26	activate	activate	VB
cord-305737-bnzd7b25	102	27	IRF3	IRF3	NNP
cord-305737-bnzd7b25	102	28	via	via	IN
cord-305737-bnzd7b25	102	29	the	the	DT
cord-305737-bnzd7b25	102	30	RIG	rig	NN
cord-305737-bnzd7b25	102	31	-	-	HYPH
cord-305737-bnzd7b25	102	32	I	I	NNP
cord-305737-bnzd7b25	102	33	/	/	SYM
cord-305737-bnzd7b25	102	34	MAVS	MAVS	NNP
cord-305737-bnzd7b25	102	35	pathway	pathway	VBP
cord-305737-bnzd7b25	102	36	[	[	-LRB-
cord-305737-bnzd7b25	102	37	21	21	CD
cord-305737-bnzd7b25	102	38	]	]	-RRB-
cord-305737-bnzd7b25	102	39	.	.	.
cord-305737-bnzd7b25	103	1	An	an	DT
cord-305737-bnzd7b25	103	2	important	important	JJ
cord-305737-bnzd7b25	103	3	question	question	NN
cord-305737-bnzd7b25	103	4	for	for	IN
cord-305737-bnzd7b25	103	5	future	future	JJ
cord-305737-bnzd7b25	103	6	studies	study	NNS
cord-305737-bnzd7b25	103	7	is	be	VBZ
cord-305737-bnzd7b25	103	8	how	how	WRB
cord-305737-bnzd7b25	103	9	signalling	signal	VBG
cord-305737-bnzd7b25	103	10	is	be	VBZ
cord-305737-bnzd7b25	103	11	terminated	terminate	VBN
cord-305737-bnzd7b25	103	12	and	and	CC
cord-305737-bnzd7b25	103	13	how	how	WRB
cord-305737-bnzd7b25	103	14	the	the	DT
cord-305737-bnzd7b25	103	15	self	self	NN
cord-305737-bnzd7b25	103	16	-	-	HYPH
cord-305737-bnzd7b25	103	17	propagating	propagate	VBG
cord-305737-bnzd7b25	103	18	prion	prion	NN
cord-305737-bnzd7b25	103	19	conformation	conformation	NN
cord-305737-bnzd7b25	103	20	of	of	IN
cord-305737-bnzd7b25	103	21	MAVS	MAVS	NNPS
cord-305737-bnzd7b25	103	22	is	be	VBZ
cord-305737-bnzd7b25	103	23	cleared	clear	VBN
cord-305737-bnzd7b25	103	24	.	.	.
cord-305737-bnzd7b25	104	1	Another	another	DT
cord-305737-bnzd7b25	104	2	area	area	NN
cord-305737-bnzd7b25	104	3	for	for	IN
cord-305737-bnzd7b25	104	4	future	future	JJ
cord-305737-bnzd7b25	104	5	research	research	NN
cord-305737-bnzd7b25	104	6	is	be	VBZ
cord-305737-bnzd7b25	104	7	the	the	DT
cord-305737-bnzd7b25	104	8	spatiotemporal	spatiotemporal	JJ
cord-305737-bnzd7b25	104	9	regulation	regulation	NN
cord-305737-bnzd7b25	104	10	of	of	IN
cord-305737-bnzd7b25	104	11	RLR	RLR	NNP
cord-305737-bnzd7b25	104	12	signalling	signalling	NN
cord-305737-bnzd7b25	104	13	and	and	CC
cord-305737-bnzd7b25	104	14	how	how	WRB
cord-305737-bnzd7b25	104	15	it	-PRON-	PRP
cord-305737-bnzd7b25	104	16	is	be	VBZ
cord-305737-bnzd7b25	104	17	governed	govern	VBN
cord-305737-bnzd7b25	104	18	by	by	IN
cord-305737-bnzd7b25	104	19	the	the	DT
cord-305737-bnzd7b25	104	20	localization	localization	NN
cord-305737-bnzd7b25	104	21	of	of	IN
cord-305737-bnzd7b25	104	22	MAVS	MAVS	NNPS
cord-305737-bnzd7b25	104	23	[	[	-LRB-
cord-305737-bnzd7b25	104	24	42	42	CD
cord-305737-bnzd7b25	104	25	]	]	-RRB-
cord-305737-bnzd7b25	104	26	.	.	.
cord-305737-bnzd7b25	105	1	Interestingly	interestingly	RB
cord-305737-bnzd7b25	105	2	,	,	,
cord-305737-bnzd7b25	105	3	MAVS	MAVS	NNP
cord-305737-bnzd7b25	105	4	has	have	VBZ
cord-305737-bnzd7b25	105	5	been	be	VBN
cord-305737-bnzd7b25	105	6	found	find	VBN
cord-305737-bnzd7b25	105	7	on	on	IN
cord-305737-bnzd7b25	105	8	mitochondria	mitochondrion	NNS
cord-305737-bnzd7b25	105	9	,	,	,
cord-305737-bnzd7b25	105	10	peroxisomes	peroxisome	NNS
cord-305737-bnzd7b25	105	11	and	and	CC
cord-305737-bnzd7b25	105	12	so	so	RB
cord-305737-bnzd7b25	105	13	-	-	HYPH
cord-305737-bnzd7b25	105	14	called	call	VBN
cord-305737-bnzd7b25	105	15	MAMs	mam	NNS
cord-305737-bnzd7b25	105	16	(	(	-LRB-
cord-305737-bnzd7b25	105	17	mitochondrial	mitochondrial	NN
cord-305737-bnzd7b25	105	18	-	-	HYPH
cord-305737-bnzd7b25	105	19	associated	associate	VBN
cord-305737-bnzd7b25	105	20	endoplasmic	endoplasmic	NN
cord-305737-bnzd7b25	105	21	reticulum	reticulum	NN
cord-305737-bnzd7b25	105	22	membranes	membrane	NNS
cord-305737-bnzd7b25	105	23	)	)	-RRB-
cord-305737-bnzd7b25	105	24	[	[	-LRB-
cord-305737-bnzd7b25	105	25	43	43	CD
cord-305737-bnzd7b25	105	26	,	,	,
cord-305737-bnzd7b25	105	27	44	44	CD
cord-305737-bnzd7b25	105	28	]	]	-RRB-
cord-305737-bnzd7b25	105	29	.	.	.
cord-305737-bnzd7b25	106	1	Much	much	JJ
cord-305737-bnzd7b25	106	2	remains	remain	VBZ
cord-305737-bnzd7b25	106	3	to	to	TO
cord-305737-bnzd7b25	106	4	be	be	VB
cord-305737-bnzd7b25	106	5	learned	learn	VBN
cord-305737-bnzd7b25	106	6	about	about	IN
cord-305737-bnzd7b25	106	7	how	how	WRB
cord-305737-bnzd7b25	106	8	MAVS	MAVS	NNP
cord-305737-bnzd7b25	106	9	localization	localization	NN
cord-305737-bnzd7b25	106	10	is	be	VBZ
cord-305737-bnzd7b25	106	11	regulated	regulate	VBN
cord-305737-bnzd7b25	106	12	and	and	CC
cord-305737-bnzd7b25	106	13	how	how	WRB
cord-305737-bnzd7b25	106	14	this	this	DT
cord-305737-bnzd7b25	106	15	impacts	impact	NNS
cord-305737-bnzd7b25	106	16	on	on	IN
cord-305737-bnzd7b25	106	17	RLR	RLR	NNP
cord-305737-bnzd7b25	106	18	signalling	signalling	NN
cord-305737-bnzd7b25	106	19	during	during	IN
cord-305737-bnzd7b25	106	20	infection	infection	NN
cord-305737-bnzd7b25	106	21	with	with	IN
cord-305737-bnzd7b25	106	22	different	different	JJ
cord-305737-bnzd7b25	106	23	viruses	virus	NNS
cord-305737-bnzd7b25	106	24	.	.	.
cord-305737-bnzd7b25	107	1	The	the	DT
cord-305737-bnzd7b25	107	2	human	human	JJ
cord-305737-bnzd7b25	107	3	genome	genome	NN
cord-305737-bnzd7b25	107	4	encodes	encode	VBZ
cord-305737-bnzd7b25	107	5	four	four	CD
cord-305737-bnzd7b25	107	6	IFITs	ifit	NNS
cord-305737-bnzd7b25	107	7	(	(	-LRB-
cord-305737-bnzd7b25	107	8	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	107	9	-	-	SYM
cord-305737-bnzd7b25	107	10	3	3	CD
cord-305737-bnzd7b25	107	11	,	,	,
cord-305737-bnzd7b25	107	12	IFIT5	ifit5	NN
cord-305737-bnzd7b25	107	13	)	)	-RRB-
cord-305737-bnzd7b25	107	14	whereas	whereas	IN
cord-305737-bnzd7b25	107	15	mice	mouse	NNS
cord-305737-bnzd7b25	107	16	have	have	VBP
cord-305737-bnzd7b25	107	17	three	three	CD
cord-305737-bnzd7b25	107	18	(	(	-LRB-
cord-305737-bnzd7b25	107	19	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	107	20	-	-	SYM
cord-305737-bnzd7b25	107	21	3	3	CD
cord-305737-bnzd7b25	107	22	)	)	-RRB-
cord-305737-bnzd7b25	107	23	[	[	-LRB-
cord-305737-bnzd7b25	107	24	6	6	CD
cord-305737-bnzd7b25	107	25	,	,	,
cord-305737-bnzd7b25	107	26	7	7	CD
cord-305737-bnzd7b25	107	27	]	]	-RRB-
cord-305737-bnzd7b25	107	28	.	.	.
cord-305737-bnzd7b25	108	1	The	the	DT
cord-305737-bnzd7b25	108	2	expression	expression	NN
cord-305737-bnzd7b25	108	3	of	of	IN
cord-305737-bnzd7b25	108	4	these	these	DT
cord-305737-bnzd7b25	108	5	proteins	protein	NNS
cord-305737-bnzd7b25	108	6	is	be	VBZ
cord-305737-bnzd7b25	108	7	potently	potently	RB
cord-305737-bnzd7b25	108	8	induced	induce	VBN
cord-305737-bnzd7b25	108	9	by	by	IN
cord-305737-bnzd7b25	108	10	IFN	IFN	NNP
cord-305737-bnzd7b25	108	11	and	and	CC
cord-305737-bnzd7b25	108	12	their	-PRON-	PRP$
cord-305737-bnzd7b25	108	13	anti	anti	JJ
cord-305737-bnzd7b25	108	14	-	-	JJ
cord-305737-bnzd7b25	108	15	viral	viral	JJ
cord-305737-bnzd7b25	108	16	function	function	NN
cord-305737-bnzd7b25	108	17	has	have	VBZ
cord-305737-bnzd7b25	108	18	been	be	VBN
cord-305737-bnzd7b25	108	19	reviewed	review	VBN
cord-305737-bnzd7b25	108	20	elsewhere	elsewhere	RB
cord-305737-bnzd7b25	108	21	[	[	-LRB-
cord-305737-bnzd7b25	108	22	6	6	CD
cord-305737-bnzd7b25	108	23	,	,	,
cord-305737-bnzd7b25	108	24	7	7	CD
cord-305737-bnzd7b25	108	25	]	]	-RRB-
cord-305737-bnzd7b25	108	26	.	.	.
cord-305737-bnzd7b25	109	1	Recent	recent	JJ
cord-305737-bnzd7b25	109	2	functional	functional	JJ
cord-305737-bnzd7b25	109	3	and	and	CC
cord-305737-bnzd7b25	109	4	structural	structural	JJ
cord-305737-bnzd7b25	109	5	data	datum	NNS
cord-305737-bnzd7b25	109	6	indicate	indicate	VBP
cord-305737-bnzd7b25	109	7	that	that	IN
cord-305737-bnzd7b25	109	8	the	the	DT
cord-305737-bnzd7b25	109	9	anti	anti	JJ
cord-305737-bnzd7b25	109	10	-	-	JJ
cord-305737-bnzd7b25	109	11	viral	viral	JJ
cord-305737-bnzd7b25	109	12	effect	effect	NN
cord-305737-bnzd7b25	109	13	of	of	IN
cord-305737-bnzd7b25	109	14	IFIT1	ifit1	NN
cord-305737-bnzd7b25	110	1	and	and	CC
cord-305737-bnzd7b25	110	2	IFIT5	ifit5	NN
cord-305737-bnzd7b25	110	3	is	be	VBZ
cord-305737-bnzd7b25	110	4	due	due	JJ
cord-305737-bnzd7b25	110	5	to	to	IN
cord-305737-bnzd7b25	110	6	their	-PRON-	PRP$
cord-305737-bnzd7b25	110	7	ability	ability	NN
cord-305737-bnzd7b25	110	8	to	to	TO
cord-305737-bnzd7b25	110	9	recognize	recognize	VB
cord-305737-bnzd7b25	110	10	5PPP	5ppp	CD
cord-305737-bnzd7b25	110	11	RNA	RNA	NNP
cord-305737-bnzd7b25	110	12	.	.	.
cord-305737-bnzd7b25	111	1	A	a	DT
cord-305737-bnzd7b25	111	2	proteomics	proteomic	NNS
cord-305737-bnzd7b25	111	3	study	study	NN
cord-305737-bnzd7b25	111	4	identified	identify	VBD
cord-305737-bnzd7b25	111	5	all	all	DT
cord-305737-bnzd7b25	111	6	four	four	CD
cord-305737-bnzd7b25	111	7	human	human	JJ
cord-305737-bnzd7b25	111	8	IFITs	ifit	NNS
cord-305737-bnzd7b25	111	9	in	in	IN
cord-305737-bnzd7b25	111	10	a	a	DT
cord-305737-bnzd7b25	111	11	pull	pull	VB
cord-305737-bnzd7b25	111	12	-	-	HYPH
cord-305737-bnzd7b25	111	13	down	down	NN
cord-305737-bnzd7b25	111	14	with	with	IN
cord-305737-bnzd7b25	111	15	synthetic	synthetic	JJ
cord-305737-bnzd7b25	111	16	5PPP	5ppp	CD
cord-305737-bnzd7b25	111	17	RNA	RNA	NNP
cord-305737-bnzd7b25	111	18	as	as	IN
cord-305737-bnzd7b25	111	19	bait	bait	NN
cord-305737-bnzd7b25	111	20	[	[	-LRB-
cord-305737-bnzd7b25	111	21	9	9	CD
cord-305737-bnzd7b25	111	22	]	]	-RRB-
cord-305737-bnzd7b25	111	23	.	.	.
cord-305737-bnzd7b25	112	1	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	112	2	and	and	CC
cord-305737-bnzd7b25	112	3	IFIT5	IFIT5	``
cord-305737-bnzd7b25	112	4	directly	directly	RB
cord-305737-bnzd7b25	112	5	bound	bind	VBN
cord-305737-bnzd7b25	112	6	to	to	IN
cord-305737-bnzd7b25	112	7	the	the	DT
cord-305737-bnzd7b25	112	8	RNA	RNA	NNP
cord-305737-bnzd7b25	112	9	,	,	,
cord-305737-bnzd7b25	112	10	whereas	whereas	IN
cord-305737-bnzd7b25	112	11	IFIT2	IFIT2	NNP
cord-305737-bnzd7b25	112	12	and	and	CC
cord-305737-bnzd7b25	112	13	IFIT3	IFIT3	NNP
cord-305737-bnzd7b25	112	14	did	do	VBD
cord-305737-bnzd7b25	112	15	so	so	RB
cord-305737-bnzd7b25	112	16	indirectly	indirectly	RB
cord-305737-bnzd7b25	112	17	,	,	,
cord-305737-bnzd7b25	112	18	through	through	IN
cord-305737-bnzd7b25	112	19	association	association	NN
cord-305737-bnzd7b25	112	20	with	with	IN
cord-305737-bnzd7b25	112	21	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	112	22	[	[	-LRB-
cord-305737-bnzd7b25	112	23	9	9	CD
cord-305737-bnzd7b25	112	24	]	]	-RRB-
cord-305737-bnzd7b25	112	25	.	.	.
cord-305737-bnzd7b25	113	1	Three	three	CD
cord-305737-bnzd7b25	113	2	viruses	virus	NNS
cord-305737-bnzd7b25	113	3	that	that	WDT
cord-305737-bnzd7b25	113	4	produce	produce	VBP
cord-305737-bnzd7b25	113	5	5PPP	5ppp	CD
cord-305737-bnzd7b25	113	6	RNA	RNA	NNP
cord-305737-bnzd7b25	113	7	(	(	-LRB-
cord-305737-bnzd7b25	113	8	vesicular	vesicular	JJ
cord-305737-bnzd7b25	113	9	stomatitis	stomatitis	NN
cord-305737-bnzd7b25	113	10	virus	virus	NN
cord-305737-bnzd7b25	113	11	(	(	-LRB-
cord-305737-bnzd7b25	113	12	VSV	VSV	NNP
cord-305737-bnzd7b25	113	13	)	)	-RRB-
cord-305737-bnzd7b25	113	14	,	,	,
cord-305737-bnzd7b25	113	15	rift	rift	NNP
cord-305737-bnzd7b25	113	16	valley	valley	NNP
cord-305737-bnzd7b25	113	17	fever	fever	NN
cord-305737-bnzd7b25	113	18	virus	virus	NN
cord-305737-bnzd7b25	113	19	and	and	CC
cord-305737-bnzd7b25	113	20	IAV	IAV	NNP
cord-305737-bnzd7b25	113	21	)	)	-RRB-
cord-305737-bnzd7b25	113	22	showed	show	VBD
cord-305737-bnzd7b25	113	23	enhanced	enhanced	JJ
cord-305737-bnzd7b25	113	24	replication	replication	NN
cord-305737-bnzd7b25	113	25	in	in	IN
cord-305737-bnzd7b25	113	26	human	human	NN
cord-305737-bnzd7b25	113	27	or	or	CC
cord-305737-bnzd7b25	113	28	mouse	mouse	NN
cord-305737-bnzd7b25	113	29	cells	cell	NNS
cord-305737-bnzd7b25	113	30	depleted	deplete	VBN
cord-305737-bnzd7b25	113	31	of	of	IN
cord-305737-bnzd7b25	113	32	Recognition	Recognition	NNP
cord-305737-bnzd7b25	113	33	of	of	IN
cord-305737-bnzd7b25	113	34	5PPP	5ppp	CD
cord-305737-bnzd7b25	113	35	RNA	RNA	NNP
cord-305737-bnzd7b25	113	36	in	in	IN
cord-305737-bnzd7b25	113	37	anti	anti	JJ
cord-305737-bnzd7b25	113	38	-	-	JJ
cord-305737-bnzd7b25	113	39	viral	viral	JJ
cord-305737-bnzd7b25	113	40	defence	defence	NN
cord-305737-bnzd7b25	113	41	Rehwinkel	Rehwinkel	NNP
cord-305737-bnzd7b25	113	42	and	and	CC
cord-305737-bnzd7b25	113	43	Reis	Reis	NNP
cord-305737-bnzd7b25	113	44	e	e	NN
cord-305737-bnzd7b25	113	45	Sousa	Sousa	NNP
cord-305737-bnzd7b25	113	46	489	489	CD
cord-305737-bnzd7b25	113	47	 	 	_SP
cord-305737-bnzd7b25	113	48	Current	Current	NNP
cord-305737-bnzd7b25	113	49	Opinion	Opinion	NNP
cord-305737-bnzd7b25	113	50	in	in	IN
cord-305737-bnzd7b25	113	51	Microbiology	Microbiology	NNP
cord-305737-bnzd7b25	113	52	RIG	RIG	NNP
cord-305737-bnzd7b25	113	53	-	-	:
cord-305737-bnzd7b25	113	54	I	I	NNP
cord-305737-bnzd7b25	113	55	and	and	CC
cord-305737-bnzd7b25	113	56	IFITs	ifit	NNS
cord-305737-bnzd7b25	113	57	recognize	recognize	VBP
cord-305737-bnzd7b25	113	58	5PPP	5ppp	CD
cord-305737-bnzd7b25	113	59	RNA	RNA	NNP
cord-305737-bnzd7b25	113	60	.	.	.
cord-305737-bnzd7b25	114	1	(	(	-LRB-
cord-305737-bnzd7b25	114	2	a	a	LS
cord-305737-bnzd7b25	114	3	)	)	-RRB-
cord-305737-bnzd7b25	115	1	Several	several	JJ
cord-305737-bnzd7b25	115	2	RNA	RNA	NNP
cord-305737-bnzd7b25	115	3	viruses	virus	NNS
cord-305737-bnzd7b25	115	4	generate	generate	VBP
cord-305737-bnzd7b25	115	5	5PPP	5ppp	CD
cord-305737-bnzd7b25	115	6	RNAs	rna	NNS
cord-305737-bnzd7b25	115	7	,	,	,
cord-305737-bnzd7b25	115	8	such	such	JJ
cord-305737-bnzd7b25	115	9	as	as	IN
cord-305737-bnzd7b25	115	10	viral	viral	JJ
cord-305737-bnzd7b25	115	11	genomic	genomic	JJ
cord-305737-bnzd7b25	115	12	RNAs	rna	NNS
cord-305737-bnzd7b25	115	13	.	.	.
cord-305737-bnzd7b25	116	1	These	these	DT
cord-305737-bnzd7b25	116	2	RNAs	rna	NNS
cord-305737-bnzd7b25	116	3	are	be	VBP
cord-305737-bnzd7b25	116	4	recognized	recognize	VBN
cord-305737-bnzd7b25	116	5	by	by	IN
cord-305737-bnzd7b25	116	6	RIG	rig	NN
cord-305737-bnzd7b25	116	7	-	-	:
cord-305737-bnzd7b25	116	8	I	-PRON-	PRP
cord-305737-bnzd7b25	116	9	that	that	WDT
cord-305737-bnzd7b25	116	10	induces	induce	VBZ
cord-305737-bnzd7b25	116	11	IFN	IFN	NNP
cord-305737-bnzd7b25	116	12	production	production	NN
cord-305737-bnzd7b25	116	13	(	(	-LRB-
cord-305737-bnzd7b25	116	14	green	green	JJ
cord-305737-bnzd7b25	116	15	)	)	-RRB-
cord-305737-bnzd7b25	116	16	.	.	.
cord-305737-bnzd7b25	117	1	IFNs	IFNs	NNP
cord-305737-bnzd7b25	117	2	then	then	RB
cord-305737-bnzd7b25	117	3	induce	induce	VB
cord-305737-bnzd7b25	117	4	the	the	DT
cord-305737-bnzd7b25	117	5	expression	expression	NN
cord-305737-bnzd7b25	117	6	of	of	IN
cord-305737-bnzd7b25	117	7	IFITs	ifit	NNS
cord-305737-bnzd7b25	117	8	that	that	WDT
cord-305737-bnzd7b25	117	9	bind	bind	VBP
cord-305737-bnzd7b25	117	10	and	and	CC
cord-305737-bnzd7b25	117	11	sequester	sequester	VB
cord-305737-bnzd7b25	117	12	5PPP	5ppp	CD
cord-305737-bnzd7b25	117	13	viral	viral	JJ
cord-305737-bnzd7b25	117	14	RNAs	rna	NNS
cord-305737-bnzd7b25	117	15	,	,	,
cord-305737-bnzd7b25	117	16	preventing	prevent	VBG
cord-305737-bnzd7b25	117	17	their	-PRON-	PRP$
cord-305737-bnzd7b25	117	18	translation	translation	NN
cord-305737-bnzd7b25	117	19	,	,	,
cord-305737-bnzd7b25	117	20	replication	replication	NN
cord-305737-bnzd7b25	117	21	and/or	and/or	CC
cord-305737-bnzd7b25	117	22	packaging	packaging	NN
cord-305737-bnzd7b25	117	23	(	(	-LRB-
cord-305737-bnzd7b25	117	24	red	red	NN
cord-305737-bnzd7b25	117	25	)	)	-RRB-
cord-305737-bnzd7b25	117	26	.	.	.
cord-305737-bnzd7b25	118	1	Note	note	VB
cord-305737-bnzd7b25	118	2	that	that	IN
cord-305737-bnzd7b25	118	3	IFITs	IFITs	NNP
cord-305737-bnzd7b25	118	4	can	can	MD
cord-305737-bnzd7b25	118	5	also	also	RB
cord-305737-bnzd7b25	118	6	be	be	VB
cord-305737-bnzd7b25	118	7	induced	induce	VBN
cord-305737-bnzd7b25	118	8	directly	directly	RB
cord-305737-bnzd7b25	118	9	by	by	IN
cord-305737-bnzd7b25	118	10	RIG	rig	NN
cord-305737-bnzd7b25	118	11	-	-	:
cord-305737-bnzd7b25	118	12	I	I	NNP
cord-305737-bnzd7b25	118	13	/	/	SYM
cord-305737-bnzd7b25	118	14	MAVS	MAVS	NNP
cord-305737-bnzd7b25	118	15	(	(	-LRB-
cord-305737-bnzd7b25	118	16	dashed	dash	VBN
cord-305737-bnzd7b25	118	17	arrow	arrow	NN
cord-305737-bnzd7b25	118	18	)	)	-RRB-
cord-305737-bnzd7b25	118	19	[	[	-LRB-
cord-305737-bnzd7b25	118	20	43	43	CD
cord-305737-bnzd7b25	118	21	]	]	-RRB-
cord-305737-bnzd7b25	118	22	.	.	.
cord-305737-bnzd7b25	119	1	(	(	-LRB-
cord-305737-bnzd7b25	119	2	b	b	LS
cord-305737-bnzd7b25	119	3	)	)	-RRB-
cord-305737-bnzd7b25	119	4	The	the	DT
cord-305737-bnzd7b25	119	5	top	top	JJ
cord-305737-bnzd7b25	119	6	row	row	NN
cord-305737-bnzd7b25	119	7	shows	show	VBZ
cord-305737-bnzd7b25	119	8	overall	overall	JJ
cord-305737-bnzd7b25	119	9	structures	structure	NNS
cord-305737-bnzd7b25	119	10	of	of	IN
cord-305737-bnzd7b25	119	11	RIG	rig	NN
cord-305737-bnzd7b25	119	12	-	-	:
cord-305737-bnzd7b25	119	13	I	i	NN
cord-305737-bnzd7b25	119	14	and	and	CC
cord-305737-bnzd7b25	119	15	IFIT5	ifit5	NN
cord-305737-bnzd7b25	119	16	in	in	IN
cord-305737-bnzd7b25	119	17	complex	complex	NN
cord-305737-bnzd7b25	119	18	with	with	IN
cord-305737-bnzd7b25	119	19	5PPP	5ppp	CD
cord-305737-bnzd7b25	119	20	RNA	RNA	NNP
cord-305737-bnzd7b25	119	21	;	;	:
cord-305737-bnzd7b25	119	22	the	the	DT
cord-305737-bnzd7b25	119	23	bottom	bottom	NN
cord-305737-bnzd7b25	119	24	row	row	NN
cord-305737-bnzd7b25	119	25	zooms	zoom	VBZ
cord-305737-bnzd7b25	119	26	in	in	RP
cord-305737-bnzd7b25	119	27	on	on	IN
cord-305737-bnzd7b25	119	28	the	the	DT
cord-305737-bnzd7b25	119	29	5PPP	5ppp	CD
cord-305737-bnzd7b25	119	30	binding	bind	VBG
cord-305737-bnzd7b25	119	31	sites	site	NNS
cord-305737-bnzd7b25	119	32	.	.	.
cord-305737-bnzd7b25	120	1	The	the	DT
cord-305737-bnzd7b25	120	2	RIG	rig	NN
cord-305737-bnzd7b25	120	3	-	-	:
cord-305737-bnzd7b25	120	4	I	-PRON-	PRP
cord-305737-bnzd7b25	120	5	structure	structure	NN
cord-305737-bnzd7b25	120	6	is	be	VBZ
cord-305737-bnzd7b25	120	7	the	the	DT
cord-305737-bnzd7b25	120	8	RIG-	RIG-	NNP
cord-305737-bnzd7b25	121	1	I	-PRON-	PRP
cord-305737-bnzd7b25	121	2	DCARD	DCARD	VBD
cord-305737-bnzd7b25	121	3	plus	plus	CC
cord-305737-bnzd7b25	121	4	5PPP	5ppp	CD
cord-305737-bnzd7b25	121	5	RNA	RNA	NNP
cord-305737-bnzd7b25	121	6	hairpin	hairpin	NN
cord-305737-bnzd7b25	121	7	complex	complex	NN
cord-305737-bnzd7b25	121	8	described	describe	VBN
cord-305737-bnzd7b25	121	9	in	in	IN
cord-305737-bnzd7b25	121	10	[	[	-LRB-
cord-305737-bnzd7b25	121	11	33	33	CD
cord-305737-bnzd7b25	121	12	]	]	-RRB-
cord-305737-bnzd7b25	122	1	(	(	-LRB-
cord-305737-bnzd7b25	122	2	PDB	PDB	NNP
cord-305737-bnzd7b25	122	3	code	code	NN
cord-305737-bnzd7b25	122	4	4AY2	4ay2	CD
cord-305737-bnzd7b25	122	5	)	)	-RRB-
cord-305737-bnzd7b25	122	6	.	.	.
cord-305737-bnzd7b25	123	1	IFIT5	IFIT5	NNP
cord-305737-bnzd7b25	123	2	is	be	VBZ
cord-305737-bnzd7b25	123	3	shown	show	VBN
cord-305737-bnzd7b25	123	4	in	in	IN
cord-305737-bnzd7b25	123	5	complex	complex	NN
cord-305737-bnzd7b25	123	6	with	with	IN
cord-305737-bnzd7b25	123	7	5PPP	5ppp	CD
cord-305737-bnzd7b25	123	8	-	-	HYPH
cord-305737-bnzd7b25	123	9	oligo	oligo	NN
cord-305737-bnzd7b25	123	10	-	-	HYPH
cord-305737-bnzd7b25	123	11	C	C	NNP
cord-305737-bnzd7b25	123	12	[	[	-LRB-
cord-305737-bnzd7b25	123	13	8	8	CD
cord-305737-bnzd7b25	123	14	]	]	-RRB-
cord-305737-bnzd7b25	123	15	(	(	-LRB-
cord-305737-bnzd7b25	123	16	PDB	PDB	NNP
cord-305737-bnzd7b25	123	17	code	code	NN
cord-305737-bnzd7b25	123	18	4HOR	4hor	CD
cord-305737-bnzd7b25	123	19	)	)	-RRB-
cord-305737-bnzd7b25	123	20	.	.	.
cord-305737-bnzd7b25	124	1	Amino	amino	NN
cord-305737-bnzd7b25	124	2	acid	acid	NN
cord-305737-bnzd7b25	124	3	residues	residue	NNS
cord-305737-bnzd7b25	124	4	contacting	contact	VBG
cord-305737-bnzd7b25	124	5	the	the	DT
cord-305737-bnzd7b25	124	6	5PPP	5ppp	CD
cord-305737-bnzd7b25	124	7	are	be	VBP
cord-305737-bnzd7b25	124	8	shown	show	VBN
cord-305737-bnzd7b25	124	9	in	in	IN
cord-305737-bnzd7b25	124	10	stick	stick	NN
cord-305737-bnzd7b25	124	11	format	format	NN
cord-305737-bnzd7b25	124	12	and	and	CC
cord-305737-bnzd7b25	124	13	dashed	dash	VBD
cord-305737-bnzd7b25	124	14	lines	line	NNS
cord-305737-bnzd7b25	124	15	indicate	indicate	VBP
cord-305737-bnzd7b25	124	16	hydrogen	hydrogen	NN
cord-305737-bnzd7b25	124	17	-	-	HYPH
cord-305737-bnzd7b25	124	18	bonding	bonding	NN
cord-305737-bnzd7b25	124	19	interactions	interaction	NNS
cord-305737-bnzd7b25	124	20	.	.	.
cord-305737-bnzd7b25	125	1	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	126	1	whereas	whereas	IN
cord-305737-bnzd7b25	126	2	replication	replication	NN
cord-305737-bnzd7b25	126	3	of	of	IN
cord-305737-bnzd7b25	126	4	encephalomyocarditis	encephalomyocarditis	NNP
cord-305737-bnzd7b25	126	5	virus	virus	NN
cord-305737-bnzd7b25	126	6	(	(	-LRB-
cord-305737-bnzd7b25	126	7	EMCV	EMCV	NNP
cord-305737-bnzd7b25	126	8	)	)	-RRB-
cord-305737-bnzd7b25	126	9	that	that	WDT
cord-305737-bnzd7b25	126	10	lacks	lack	VBZ
cord-305737-bnzd7b25	126	11	5PPPs	5ppps	NN
cord-305737-bnzd7b25	126	12	was	be	VBD
cord-305737-bnzd7b25	126	13	normal	normal	JJ
cord-305737-bnzd7b25	126	14	[	[	-LRB-
cord-305737-bnzd7b25	126	15	9	9	CD
cord-305737-bnzd7b25	126	16	]	]	-RRB-
cord-305737-bnzd7b25	126	17	.	.	.
cord-305737-bnzd7b25	127	1	What	what	WP
cord-305737-bnzd7b25	127	2	is	be	VBZ
cord-305737-bnzd7b25	127	3	the	the	DT
cord-305737-bnzd7b25	127	4	molecular	molecular	JJ
cord-305737-bnzd7b25	127	5	basis	basis	NN
cord-305737-bnzd7b25	127	6	of	of	IN
cord-305737-bnzd7b25	127	7	IFIT1	ifit1	JJ
cord-305737-bnzd7b25	127	8	mediated	mediate	VBN
cord-305737-bnzd7b25	127	9	inhibition	inhibition	NN
cord-305737-bnzd7b25	127	10	of	of	IN
cord-305737-bnzd7b25	127	11	virus	virus	NN
cord-305737-bnzd7b25	127	12	replication	replication	NN
cord-305737-bnzd7b25	127	13	?	?	.
cord-305737-bnzd7b25	128	1	In	in	IN
cord-305737-bnzd7b25	128	2	vitro	vitro	FW
cord-305737-bnzd7b25	128	3	assays	assay	NNS
cord-305737-bnzd7b25	128	4	showed	show	VBD
cord-305737-bnzd7b25	128	5	that	that	IN
cord-305737-bnzd7b25	128	6	recombinant	recombinant	JJ
cord-305737-bnzd7b25	128	7	IFIT1	ifit1	JJ
cord-305737-bnzd7b25	128	8	blocks	block	NNS
cord-305737-bnzd7b25	128	9	translation	translation	NN
cord-305737-bnzd7b25	128	10	of	of	IN
cord-305737-bnzd7b25	128	11	5PPP	5ppp	CD
cord-305737-bnzd7b25	128	12	containing	contain	VBG
cord-305737-bnzd7b25	128	13	reporter	reporter	NN
cord-305737-bnzd7b25	128	14	RNAs	rna	NNS
cord-305737-bnzd7b25	128	15	,	,	,
cord-305737-bnzd7b25	128	16	while	while	IN
cord-305737-bnzd7b25	128	17	having	have	VBG
cord-305737-bnzd7b25	128	18	little	little	JJ
cord-305737-bnzd7b25	128	19	effect	effect	NN
cord-305737-bnzd7b25	128	20	on	on	IN
cord-305737-bnzd7b25	128	21	translation	translation	NN
cord-305737-bnzd7b25	128	22	of	of	IN
cord-305737-bnzd7b25	128	23	the	the	DT
cord-305737-bnzd7b25	128	24	corresponding	correspond	VBG
cord-305737-bnzd7b25	128	25	dephosphorylated	dephosphorylated	JJ
cord-305737-bnzd7b25	128	26	RNA	RNA	NNP
cord-305737-bnzd7b25	128	27	[	[	-LRB-
cord-305737-bnzd7b25	128	28	9	9	CD
cord-305737-bnzd7b25	128	29	]	]	-RRB-
cord-305737-bnzd7b25	128	30	.	.	.
cord-305737-bnzd7b25	129	1	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	129	2	also	also	RB
cord-305737-bnzd7b25	129	3	precipitated	precipitate	VBD
cord-305737-bnzd7b25	129	4	viral	viral	JJ
cord-305737-bnzd7b25	129	5	RNAs	rna	NNS
cord-305737-bnzd7b25	129	6	from	from	IN
cord-305737-bnzd7b25	129	7	cells	cell	NNS
cord-305737-bnzd7b25	129	8	infected	infect	VBN
cord-305737-bnzd7b25	129	9	with	with	IN
cord-305737-bnzd7b25	129	10	VSV	VSV	NNP
cord-305737-bnzd7b25	129	11	or	or	CC
cord-305737-bnzd7b25	129	12	IAV	IAV	NNP
cord-305737-bnzd7b25	129	13	[	[	-LRB-
cord-305737-bnzd7b25	129	14	9	9	CD
cord-305737-bnzd7b25	129	15	]	]	-RRB-
cord-305737-bnzd7b25	129	16	.	.	.
cord-305737-bnzd7b25	130	1	Together	together	RB
cord-305737-bnzd7b25	130	2	,	,	,
cord-305737-bnzd7b25	130	3	these	these	DT
cord-305737-bnzd7b25	130	4	observations	observation	NNS
cord-305737-bnzd7b25	130	5	suggest	suggest	VBP
cord-305737-bnzd7b25	130	6	that	that	IN
cord-305737-bnzd7b25	130	7	IFIT1	ifit1	JJ
cord-305737-bnzd7b25	130	8	recognizes	recognize	VBZ
cord-305737-bnzd7b25	130	9	and	and	CC
cord-305737-bnzd7b25	130	10	sequesters	sequester	VBZ
cord-305737-bnzd7b25	130	11	viral	viral	JJ
cord-305737-bnzd7b25	130	12	5PPP	5ppp	CD
cord-305737-bnzd7b25	130	13	RNAs	rna	NNS
cord-305737-bnzd7b25	130	14	and	and	CC
cord-305737-bnzd7b25	130	15	thereby	thereby	RB
cord-305737-bnzd7b25	130	16	prevents	prevent	VBZ
cord-305737-bnzd7b25	130	17	their	-PRON-	PRP$
cord-305737-bnzd7b25	130	18	replication	replication	NN
cord-305737-bnzd7b25	130	19	,	,	,
cord-305737-bnzd7b25	130	20	packaging	packaging	NN
cord-305737-bnzd7b25	130	21	and/or	and/or	CC
cord-305737-bnzd7b25	130	22	translation	translation	NN
cord-305737-bnzd7b25	130	23	.	.	.
cord-305737-bnzd7b25	131	1	Structural	structural	JJ
cord-305737-bnzd7b25	131	2	data	datum	NNS
cord-305737-bnzd7b25	131	3	demonstrate	demonstrate	VBP
cord-305737-bnzd7b25	131	4	that	that	IN
cord-305737-bnzd7b25	131	5	human	human	JJ
cord-305737-bnzd7b25	131	6	IFIT5	ifit5	NN
cord-305737-bnzd7b25	131	7	has	have	VBZ
cord-305737-bnzd7b25	131	8	a	a	DT
cord-305737-bnzd7b25	131	9	positively	positively	RB
cord-305737-bnzd7b25	131	10	charged	charge	VBN
cord-305737-bnzd7b25	131	11	cavity	cavity	NN
cord-305737-bnzd7b25	131	12	accommodating	accommodate	VBG
cord-305737-bnzd7b25	131	13	5PPP	5ppp	CD
cord-305737-bnzd7b25	131	14	RNA	RNA	NNP
cord-305737-bnzd7b25	131	15	[	[	-LRB-
cord-305737-bnzd7b25	131	16	8	8	CD
cord-305737-bnzd7b25	131	17	]	]	-RRB-
cord-305737-bnzd7b25	131	18	(	(	-LRB-
cord-305737-bnzd7b25	131	19	Figure	figure	NN
cord-305737-bnzd7b25	131	20	3b	3b	CD
cord-305737-bnzd7b25	131	21	)	)	-RRB-
cord-305737-bnzd7b25	131	22	.	.	.
cord-305737-bnzd7b25	132	1	Structure	structure	NN
cord-305737-bnzd7b25	132	2	-	-	HYPH
cord-305737-bnzd7b25	132	3	guided	guide	VBN
cord-305737-bnzd7b25	132	4	mutation	mutation	NN
cord-305737-bnzd7b25	132	5	of	of	IN
cord-305737-bnzd7b25	132	6	residues	residue	NNS
cord-305737-bnzd7b25	132	7	involved	involve	VBN
cord-305737-bnzd7b25	132	8	in	in	IN
cord-305737-bnzd7b25	132	9	5PPP	5ppp	CD
cord-305737-bnzd7b25	132	10	RNA	RNA	NNP
cord-305737-bnzd7b25	132	11	binding	binding	NN
cord-305737-bnzd7b25	132	12	diminishes	diminish	VBZ
cord-305737-bnzd7b25	132	13	the	the	DT
cord-305737-bnzd7b25	132	14	anti	anti	JJ
cord-305737-bnzd7b25	132	15	-	-	JJ
cord-305737-bnzd7b25	132	16	viral	viral	JJ
cord-305737-bnzd7b25	132	17	effects	effect	NNS
cord-305737-bnzd7b25	132	18	of	of	IN
cord-305737-bnzd7b25	132	19	IFIT5	ifit5	NN
cord-305737-bnzd7b25	132	20	and	and	CC
cord-305737-bnzd7b25	132	21	IFIT1	ifit1	VB
cord-305737-bnzd7b25	132	22	against	against	IN
cord-305737-bnzd7b25	132	23	VSV	VSV	NNP
cord-305737-bnzd7b25	132	24	and	and	CC
cord-305737-bnzd7b25	132	25	IAV	IAV	NNP
cord-305737-bnzd7b25	132	26	[	[	-LRB-
cord-305737-bnzd7b25	132	27	8	8	CD
cord-305737-bnzd7b25	132	28	,	,	,
cord-305737-bnzd7b25	132	29	9	9	CD
cord-305737-bnzd7b25	132	30	]	]	-RRB-
cord-305737-bnzd7b25	132	31	.	.	.
cord-305737-bnzd7b25	133	1	Similar	similar	JJ
cord-305737-bnzd7b25	133	2	to	to	IN
cord-305737-bnzd7b25	133	3	5PPP	5ppp	CD
cord-305737-bnzd7b25	133	4	RNA	RNA	NNP
cord-305737-bnzd7b25	133	5	recognition	recognition	NN
cord-305737-bnzd7b25	133	6	by	by	IN
cord-305737-bnzd7b25	133	7	RIG	rig	NN
cord-305737-bnzd7b25	133	8	-	-	:
cord-305737-bnzd7b25	133	9	I	I	NNP
cord-305737-bnzd7b25	133	10	,	,	,
cord-305737-bnzd7b25	133	11	the	the	DT
cord-305737-bnzd7b25	133	12	interaction	interaction	NN
cord-305737-bnzd7b25	133	13	between	between	IN
cord-305737-bnzd7b25	133	14	IFIT5	IFIT5	NNP
cord-305737-bnzd7b25	133	15	and	and	CC
cord-305737-bnzd7b25	133	16	RNA	RNA	NNP
cord-305737-bnzd7b25	133	17	is	be	VBZ
cord-305737-bnzd7b25	133	18	not	not	RB
cord-305737-bnzd7b25	133	19	sequence	sequence	NN
cord-305737-bnzd7b25	133	20	specific	specific	JJ
cord-305737-bnzd7b25	133	21	[	[	-LRB-
cord-305737-bnzd7b25	133	22	8	8	CD
cord-305737-bnzd7b25	133	23	,	,	,
cord-305737-bnzd7b25	133	24	22,23	22,23	CD
cord-305737-bnzd7b25	133	25	]	]	-RRB-
cord-305737-bnzd7b25	133	26	.	.	.
cord-305737-bnzd7b25	134	1	However	however	RB
cord-305737-bnzd7b25	134	2	,	,	,
cord-305737-bnzd7b25	134	3	while	while	IN
cord-305737-bnzd7b25	134	4	RIG	rig	NN
cord-305737-bnzd7b25	134	5	-	-	:
cord-305737-bnzd7b25	134	6	I	-PRON-	PRP
cord-305737-bnzd7b25	134	7	is	be	VBZ
cord-305737-bnzd7b25	134	8	most	most	RBS
cord-305737-bnzd7b25	134	9	strongly	strongly	RB
cord-305737-bnzd7b25	134	10	activated	activate	VBN
cord-305737-bnzd7b25	134	11	by	by	IN
cord-305737-bnzd7b25	134	12	blunt	blunt	JJ
cord-305737-bnzd7b25	134	13	ended	end	VBN
cord-305737-bnzd7b25	134	14	5PPP	5ppp	CD
cord-305737-bnzd7b25	134	15	base	base	NN
cord-305737-bnzd7b25	134	16	-	-	HYPH
cord-305737-bnzd7b25	134	17	paired	pair	VBN
cord-305737-bnzd7b25	134	18	RNA	RNA	NNP
cord-305737-bnzd7b25	134	19	[	[	-LRB-
cord-305737-bnzd7b25	134	20	11	11	CD
cord-305737-bnzd7b25	134	21	]	]	-RRB-
cord-305737-bnzd7b25	134	22	,	,	,
cord-305737-bnzd7b25	134	23	a	a	DT
cord-305737-bnzd7b25	134	24	5	5	CD
cord-305737-bnzd7b25	134	25	0	0	CD
cord-305737-bnzd7b25	134	26	-overhang	-overhang	:
cord-305737-bnzd7b25	134	27	is	be	VBZ
cord-305737-bnzd7b25	134	28	required	require	VBN
cord-305737-bnzd7b25	134	29	for	for	IN
cord-305737-bnzd7b25	134	30	RNA	RNA	NNP
cord-305737-bnzd7b25	134	31	to	to	TO
cord-305737-bnzd7b25	134	32	be	be	VB
cord-305737-bnzd7b25	134	33	accommodated	accommodate	VBN
cord-305737-bnzd7b25	134	34	in	in	IN
cord-305737-bnzd7b25	134	35	IFIT5	ifit5	$
cord-305737-bnzd7b25	134	36	[	[	-LRB-
cord-305737-bnzd7b25	134	37	8	8	CD
cord-305737-bnzd7b25	134	38	]	]	-RRB-
cord-305737-bnzd7b25	134	39	.	.	.
cord-305737-bnzd7b25	135	1	Whether	whether	IN
cord-305737-bnzd7b25	135	2	this	this	DT
cord-305737-bnzd7b25	135	3	reflects	reflect	VBZ
cord-305737-bnzd7b25	135	4	binding	bind	VBG
cord-305737-bnzd7b25	135	5	of	of	IN
cord-305737-bnzd7b25	135	6	different	different	JJ
cord-305737-bnzd7b25	135	7	types	type	NNS
cord-305737-bnzd7b25	135	8	of	of	IN
cord-305737-bnzd7b25	135	9	RNA	RNA	NNP
cord-305737-bnzd7b25	135	10	to	to	IN
cord-305737-bnzd7b25	135	11	IFITs	IFITs	NNP
cord-305737-bnzd7b25	135	12	and	and	CC
cord-305737-bnzd7b25	135	13	RIG	rig	NN
cord-305737-bnzd7b25	135	14	-	-	:
cord-305737-bnzd7b25	135	15	I	-PRON-	PRP
cord-305737-bnzd7b25	135	16	or	or	CC
cord-305737-bnzd7b25	135	17	whether	whether	IN
cord-305737-bnzd7b25	135	18	base	base	NN
cord-305737-bnzd7b25	135	19	-	-	HYPH
cord-305737-bnzd7b25	135	20	paired	pair	VBN
cord-305737-bnzd7b25	135	21	RIG	rig	NN
cord-305737-bnzd7b25	135	22	-	-	:
cord-305737-bnzd7b25	135	23	I	-PRON-	PRP
cord-305737-bnzd7b25	135	24	agonists	agonist	NNS
cord-305737-bnzd7b25	135	25	are	be	VBP
cord-305737-bnzd7b25	135	26	unwound	unwind	VBN
cord-305737-bnzd7b25	135	27	for	for	IN
cord-305737-bnzd7b25	135	28	IFIT	ifit	NN
cord-305737-bnzd7b25	135	29	recognition	recognition	NN
cord-305737-bnzd7b25	135	30	remains	remain	VBZ
cord-305737-bnzd7b25	135	31	to	to	TO
cord-305737-bnzd7b25	135	32	be	be	VB
cord-305737-bnzd7b25	135	33	determined	determine	VBN
cord-305737-bnzd7b25	135	34	.	.	.
cord-305737-bnzd7b25	136	1	Genetically	genetically	RB
cord-305737-bnzd7b25	136	2	modified	modify	VBN
cord-305737-bnzd7b25	136	3	mice	mouse	NNS
cord-305737-bnzd7b25	136	4	provide	provide	VBP
cord-305737-bnzd7b25	136	5	further	further	JJ
cord-305737-bnzd7b25	136	6	evidence	evidence	NN
cord-305737-bnzd7b25	136	7	for	for	IN
cord-305737-bnzd7b25	136	8	a	a	DT
cord-305737-bnzd7b25	136	9	role	role	NN
cord-305737-bnzd7b25	136	10	of	of	IN
cord-305737-bnzd7b25	136	11	IFITs	IFITs	NNP
cord-305737-bnzd7b25	136	12	in	in	IN
cord-305737-bnzd7b25	136	13	host	host	NN
cord-305737-bnzd7b25	136	14	defence	defence	NN
cord-305737-bnzd7b25	136	15	against	against	IN
cord-305737-bnzd7b25	136	16	viruses	virus	NNS
cord-305737-bnzd7b25	136	17	[	[	-LRB-
cord-305737-bnzd7b25	136	18	9	9	CD
cord-305737-bnzd7b25	136	19	,	,	,
cord-305737-bnzd7b25	136	20	45,46,47	45,46,47	CD
cord-305737-bnzd7b25	136	21	]	]	-RRB-
cord-305737-bnzd7b25	136	22	.	.	.
cord-305737-bnzd7b25	137	1	IFIT2-deficient	ifit2-deficient	LS
cord-305737-bnzd7b25	137	2	animals	animal	NNS
cord-305737-bnzd7b25	137	3	are	be	VBP
cord-305737-bnzd7b25	137	4	highly	highly	RB
cord-305737-bnzd7b25	137	5	susceptible	susceptible	JJ
cord-305737-bnzd7b25	137	6	to	to	IN
cord-305737-bnzd7b25	137	7	intranasal	intranasal	JJ
cord-305737-bnzd7b25	137	8	VSV	VSV	NNP
cord-305737-bnzd7b25	137	9	challenge	challenge	NN
cord-305737-bnzd7b25	137	10	[	[	-LRB-
cord-305737-bnzd7b25	137	11	46	46	CD
cord-305737-bnzd7b25	137	12	]	]	-RRB-
cord-305737-bnzd7b25	137	13	,	,	,
cord-305737-bnzd7b25	137	14	and	and	CC
cord-305737-bnzd7b25	137	15	similar	similar	JJ
cord-305737-bnzd7b25	137	16	data	datum	NNS
cord-305737-bnzd7b25	137	17	have	have	VBP
cord-305737-bnzd7b25	137	18	been	be	VBN
cord-305737-bnzd7b25	137	19	reported	report	VBN
cord-305737-bnzd7b25	137	20	for	for	IN
cord-305737-bnzd7b25	137	21	Ifit1	Ifit1	NNP
cord-305737-bnzd7b25	137	22	À	À	NNP
cord-305737-bnzd7b25	137	23	/	/	SYM
cord-305737-bnzd7b25	137	24	À	à	NN
cord-305737-bnzd7b25	137	25	mice	mouse	NNS
cord-305737-bnzd7b25	137	26	[	[	-LRB-
cord-305737-bnzd7b25	137	27	9	9	CD
cord-305737-bnzd7b25	137	28	]	]	-RRB-
cord-305737-bnzd7b25	137	29	.	.	.
cord-305737-bnzd7b25	138	1	It	-PRON-	PRP
cord-305737-bnzd7b25	138	2	is	be	VBZ
cord-305737-bnzd7b25	138	3	unclear	unclear	JJ
cord-305737-bnzd7b25	138	4	why	why	WRB
cord-305737-bnzd7b25	138	5	another	another	DT
cord-305737-bnzd7b25	138	6	study	study	NN
cord-305737-bnzd7b25	138	7	using	use	VBG
cord-305737-bnzd7b25	138	8	IFIT1-deficient	IFIT1-deficient	NNP
cord-305737-bnzd7b25	138	9	mice	mouse	NNS
cord-305737-bnzd7b25	138	10	independently	independently	RB
cord-305737-bnzd7b25	138	11	derived	derive	VBN
cord-305737-bnzd7b25	138	12	from	from	IN
cord-305737-bnzd7b25	138	13	the	the	DT
cord-305737-bnzd7b25	138	14	same	same	JJ
cord-305737-bnzd7b25	138	15	ES	es	NN
cord-305737-bnzd7b25	138	16	cell	cell	NN
cord-305737-bnzd7b25	138	17	line	line	NN
cord-305737-bnzd7b25	138	18	failed	fail	VBD
cord-305737-bnzd7b25	138	19	to	to	TO
cord-305737-bnzd7b25	138	20	reproduce	reproduce	VB
cord-305737-bnzd7b25	138	21	these	these	DT
cord-305737-bnzd7b25	138	22	results	result	NNS
cord-305737-bnzd7b25	138	23	[	[	-LRB-
cord-305737-bnzd7b25	138	24	9	9	CD
cord-305737-bnzd7b25	138	25	,	,	,
cord-305737-bnzd7b25	138	26	46	46	CD
cord-305737-bnzd7b25	138	27	]	]	-RRB-
cord-305737-bnzd7b25	138	28	.	.	.
cord-305737-bnzd7b25	139	1	Interestingly	interestingly	RB
cord-305737-bnzd7b25	139	2	,	,	,
cord-305737-bnzd7b25	139	3	Ifit1	Ifit1	NNP
cord-305737-bnzd7b25	139	4	À	à	NN
cord-305737-bnzd7b25	139	5	/	/	SYM
cord-305737-bnzd7b25	139	6	À	à	NN
cord-305737-bnzd7b25	139	7	mice	mouse	NNS
cord-305737-bnzd7b25	139	8	and	and	CC
cord-305737-bnzd7b25	139	9	cells	cell	NNS
cord-305737-bnzd7b25	139	10	are	be	VBP
cord-305737-bnzd7b25	139	11	more	more	RBR
cord-305737-bnzd7b25	139	12	susceptible	susceptible	JJ
cord-305737-bnzd7b25	139	13	to	to	IN
cord-305737-bnzd7b25	139	14	infection	infection	NN
cord-305737-bnzd7b25	139	15	with	with	IN
cord-305737-bnzd7b25	139	16	viruses	virus	NNS
cord-305737-bnzd7b25	139	17	lacking	lack	VBG
cord-305737-bnzd7b25	139	18	2	2	CD
cord-305737-bnzd7b25	139	19	0	0	CD
cord-305737-bnzd7b25	139	20	-O	-o	CD
cord-305737-bnzd7b25	139	21	-	-	HYPH
cord-305737-bnzd7b25	139	22	methyltransferases	methyltransferase	NNS
cord-305737-bnzd7b25	139	23	,	,	,
cord-305737-bnzd7b25	139	24	including	include	VBG
cord-305737-bnzd7b25	139	25	mutants	mutant	NNS
cord-305737-bnzd7b25	139	26	of	of	IN
cord-305737-bnzd7b25	139	27	West	West	NNP
cord-305737-bnzd7b25	139	28	Nile	Nile	NNP
cord-305737-bnzd7b25	139	29	virus	virus	NN
cord-305737-bnzd7b25	139	30	,	,	,
cord-305737-bnzd7b25	139	31	coronavirus	coronavirus	NN
cord-305737-bnzd7b25	139	32	and	and	CC
cord-305737-bnzd7b25	139	33	poxvirus	poxvirus	NNP
cord-305737-bnzd7b25	139	34	[	[	-LRB-
cord-305737-bnzd7b25	139	35	45	45	CD
cord-305737-bnzd7b25	139	36	,	,	,
cord-305737-bnzd7b25	139	37	47	47	CD
cord-305737-bnzd7b25	139	38	,	,	,
cord-305737-bnzd7b25	139	39	48	48	CD
cord-305737-bnzd7b25	139	40	]	]	-RRB-
cord-305737-bnzd7b25	139	41	.	.	.
cord-305737-bnzd7b25	140	1	The	the	DT
cord-305737-bnzd7b25	140	2	2	2	CD
cord-305737-bnzd7b25	140	3	0	0	CD
cord-305737-bnzd7b25	140	4	-O	-o	CD
cord-305737-bnzd7b25	140	5	-	-	HYPH
cord-305737-bnzd7b25	140	6	methyltransferases	methyltransferase	NNS
cord-305737-bnzd7b25	140	7	encoded	encode	VBN
cord-305737-bnzd7b25	140	8	by	by	IN
cord-305737-bnzd7b25	140	9	the	the	DT
cord-305737-bnzd7b25	140	10	wild	wild	JJ
cord-305737-bnzd7b25	140	11	-	-	HYPH
cord-305737-bnzd7b25	140	12	type	type	NN
cord-305737-bnzd7b25	140	13	counterparts	counterpart	NNS
cord-305737-bnzd7b25	140	14	of	of	IN
cord-305737-bnzd7b25	140	15	these	these	DT
cord-305737-bnzd7b25	140	16	mutant	mutant	JJ
cord-305737-bnzd7b25	140	17	strains	strain	NNS
cord-305737-bnzd7b25	140	18	modify	modify	VBP
cord-305737-bnzd7b25	140	19	the	the	DT
cord-305737-bnzd7b25	140	20	cap	cap	NN
cord-305737-bnzd7b25	140	21	structure	structure	NN
cord-305737-bnzd7b25	140	22	of	of	IN
cord-305737-bnzd7b25	140	23	viral	viral	JJ
cord-305737-bnzd7b25	140	24	messenger	messenger	NNP
cord-305737-bnzd7b25	140	25	RNA	RNA	NNP
cord-305737-bnzd7b25	140	26	by	by	IN
cord-305737-bnzd7b25	140	27	2	2	CD
cord-305737-bnzd7b25	140	28	0	0	CD
cord-305737-bnzd7b25	140	29	-O	-o	CD
cord-305737-bnzd7b25	140	30	-	-	HYPH
cord-305737-bnzd7b25	140	31	methylation	methylation	NN
cord-305737-bnzd7b25	140	32	.	.	.
cord-305737-bnzd7b25	141	1	Cellular	cellular	JJ
cord-305737-bnzd7b25	141	2	messenger	messenger	NN
cord-305737-bnzd7b25	141	3	RNAs	rna	NNS
cord-305737-bnzd7b25	141	4	are	be	VBP
cord-305737-bnzd7b25	141	5	methylated	methylate	VBN
cord-305737-bnzd7b25	141	6	at	at	IN
cord-305737-bnzd7b25	141	7	this	this	DT
cord-305737-bnzd7b25	141	8	position	position	NN
cord-305737-bnzd7b25	141	9	by	by	IN
cord-305737-bnzd7b25	141	10	a	a	DT
cord-305737-bnzd7b25	141	11	host	host	NN
cord-305737-bnzd7b25	141	12	-	-	HYPH
cord-305737-bnzd7b25	141	13	encoded	encode	VBN
cord-305737-bnzd7b25	141	14	methyltransferase	methyltransferase	NN
cord-305737-bnzd7b25	141	15	,	,	,
cord-305737-bnzd7b25	141	16	suggesting	suggest	VBG
cord-305737-bnzd7b25	141	17	that	that	IN
cord-305737-bnzd7b25	141	18	some	some	DT
cord-305737-bnzd7b25	141	19	viruses	virus	NNS
cord-305737-bnzd7b25	141	20	mimic	mimic	VBP
cord-305737-bnzd7b25	141	21	this	this	DT
cord-305737-bnzd7b25	141	22	to	to	TO
cord-305737-bnzd7b25	141	23	circumvent	circumvent	VB
cord-305737-bnzd7b25	141	24	recognition	recognition	NN
cord-305737-bnzd7b25	141	25	by	by	IN
cord-305737-bnzd7b25	141	26	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	142	1	and	and	CC
cord-305737-bnzd7b25	142	2	,	,	,
cord-305737-bnzd7b25	142	3	possibly	possibly	RB
cord-305737-bnzd7b25	142	4	,	,	,
cord-305737-bnzd7b25	142	5	MDA5	MDA5	NNP
cord-305737-bnzd7b25	142	6	[	[	-LRB-
cord-305737-bnzd7b25	142	7	45	45	CD
cord-305737-bnzd7b25	142	8	,	,	,
cord-305737-bnzd7b25	142	9	47	47	CD
cord-305737-bnzd7b25	142	10	,	,	,
cord-305737-bnzd7b25	142	11	48	48	CD
cord-305737-bnzd7b25	142	12	]	]	-RRB-
cord-305737-bnzd7b25	142	13	.	.	.
cord-305737-bnzd7b25	143	1	This	this	DT
cord-305737-bnzd7b25	143	2	indicates	indicate	VBZ
cord-305737-bnzd7b25	143	3	that	that	IN
cord-305737-bnzd7b25	143	4	IFIT1	IFIT1	NNP
cord-305737-bnzd7b25	143	5	may	may	MD
cord-305737-bnzd7b25	143	6	interact	interact	VB
cord-305737-bnzd7b25	143	7	not	not	RB
cord-305737-bnzd7b25	143	8	only	only	RB
cord-305737-bnzd7b25	143	9	with	with	IN
cord-305737-bnzd7b25	143	10	5PPP	5ppp	CD
cord-305737-bnzd7b25	143	11	RNA	RNA	NNP
cord-305737-bnzd7b25	143	12	,	,	,
cord-305737-bnzd7b25	143	13	but	but	CC
cord-305737-bnzd7b25	143	14	also	also	RB
cord-305737-bnzd7b25	143	15	with	with	IN
cord-305737-bnzd7b25	143	16	capped	cap	VBN
cord-305737-bnzd7b25	143	17	RNA	RNA	NNP
cord-305737-bnzd7b25	143	18	lacking	lack	VBG
cord-305737-bnzd7b25	143	19	2	2	CD
cord-305737-bnzd7b25	143	20	0	0	CD
cord-305737-bnzd7b25	144	1	-Omethyl	-Omethyl	NNP
cord-305737-bnzd7b25	144	2	groups	group	NNS
cord-305737-bnzd7b25	144	3	,	,	,
cord-305737-bnzd7b25	144	4	although	although	IN
cord-305737-bnzd7b25	144	5	the	the	DT
cord-305737-bnzd7b25	144	6	latter	latter	JJ
cord-305737-bnzd7b25	144	7	interaction	interaction	NN
cord-305737-bnzd7b25	144	8	could	could	MD
cord-305737-bnzd7b25	144	9	be	be	VB
cord-305737-bnzd7b25	144	10	indirect	indirect	JJ
cord-305737-bnzd7b25	144	11	,	,	,
cord-305737-bnzd7b25	144	12	perhaps	perhaps	RB
cord-305737-bnzd7b25	144	13	via	via	IN
cord-305737-bnzd7b25	144	14	other	other	JJ
cord-305737-bnzd7b25	144	15	IFITs	ifit	NNS
cord-305737-bnzd7b25	144	16	.	.	.
cord-305737-bnzd7b25	145	1	Indeed	indeed	RB
cord-305737-bnzd7b25	145	2	,	,	,
cord-305737-bnzd7b25	145	3	a	a	DT
cord-305737-bnzd7b25	145	4	large	large	JJ
cord-305737-bnzd7b25	145	5	spectrum	spectrum	NN
cord-305737-bnzd7b25	145	6	of	of	IN
cord-305737-bnzd7b25	145	7	different	different	JJ
cord-305737-bnzd7b25	145	8	RNAs	rna	NNS
cord-305737-bnzd7b25	145	9	may	may	MD
cord-305737-bnzd7b25	145	10	be	be	VB
cord-305737-bnzd7b25	145	11	targeted	target	VBN
cord-305737-bnzd7b25	145	12	by	by	IN
cord-305737-bnzd7b25	145	13	IFITs	ifit	NNS
cord-305737-bnzd7b25	145	14	:	:	:
cord-305737-bnzd7b25	145	15	IFIT5	IFIT5	:
cord-305737-bnzd7b25	145	16	not	not	RB
cord-305737-bnzd7b25	145	17	only	only	RB
cord-305737-bnzd7b25	145	18	binds	bind	VBZ
cord-305737-bnzd7b25	145	19	to	to	IN
cord-305737-bnzd7b25	145	20	5PPP	5ppp	CD
cord-305737-bnzd7b25	145	21	RNA	RNA	NNP
cord-305737-bnzd7b25	145	22	but	but	CC
cord-305737-bnzd7b25	145	23	also	also	RB
cord-305737-bnzd7b25	145	24	to	to	TO
cord-305737-bnzd7b25	145	25	transfer	transfer	VB
cord-305737-bnzd7b25	145	26	RNAs	rna	NNS
cord-305737-bnzd7b25	145	27	that	that	WDT
cord-305737-bnzd7b25	145	28	bear	bear	VBP
cord-305737-bnzd7b25	145	29	a	a	DT
cord-305737-bnzd7b25	145	30	single	single	JJ
cord-305737-bnzd7b25	145	31	5	5	CD
cord-305737-bnzd7b25	145	32	0	0	CD
cord-305737-bnzd7b25	145	33	-phosphate	-phosphate	.
cord-305737-bnzd7b25	146	1	[	[	-LRB-
cord-305737-bnzd7b25	146	2	49	49	CD
cord-305737-bnzd7b25	146	3	]	]	-RRB-
cord-305737-bnzd7b25	146	4	and	and	CC
cord-305737-bnzd7b25	146	5	IFIT2	IFIT2	NNP
cord-305737-bnzd7b25	146	6	interacts	interact	VBZ
cord-305737-bnzd7b25	146	7	with	with	IN
cord-305737-bnzd7b25	146	8	AU	AU	NNP
cord-305737-bnzd7b25	146	9	-	-	HYPH
cord-305737-bnzd7b25	146	10	rich	rich	JJ
cord-305737-bnzd7b25	146	11	RNAs	rna	NNS
cord-305737-bnzd7b25	146	12	independently	independently	RB
cord-305737-bnzd7b25	146	13	of	of	IN
cord-305737-bnzd7b25	146	14	5	5	CD
cord-305737-bnzd7b25	146	15	0	0	CD
cord-305737-bnzd7b25	146	16	-phosphorylation	-phosphorylation	CD
cord-305737-bnzd7b25	146	17	[	[	-LRB-
cord-305737-bnzd7b25	146	18	50	50	CD
cord-305737-bnzd7b25	146	19	]	]	-RRB-
cord-305737-bnzd7b25	146	20	.	.	.
cord-305737-bnzd7b25	147	1	It	-PRON-	PRP
cord-305737-bnzd7b25	147	2	will	will	MD
cord-305737-bnzd7b25	147	3	be	be	VB
cord-305737-bnzd7b25	147	4	important	important	JJ
cord-305737-bnzd7b25	147	5	to	to	TO
cord-305737-bnzd7b25	147	6	identify	identify	VB
cord-305737-bnzd7b25	147	7	and	and	CC
cord-305737-bnzd7b25	147	8	characterize	characterize	VB
cord-305737-bnzd7b25	147	9	RNAs	rna	NNS
cord-305737-bnzd7b25	147	10	bound	bind	VBN
cord-305737-bnzd7b25	147	11	by	by	IN
cord-305737-bnzd7b25	147	12	IFITs	ifit	NNS
cord-305737-bnzd7b25	147	13	in	in	IN
cord-305737-bnzd7b25	147	14	virally	virally	RB
cord-305737-bnzd7b25	147	15	infected	infect	VBN
cord-305737-bnzd7b25	147	16	cells	cell	NNS
cord-305737-bnzd7b25	147	17	to	to	TO
cord-305737-bnzd7b25	147	18	further	further	RB
cord-305737-bnzd7b25	147	19	understand	understand	VB
cord-305737-bnzd7b25	147	20	the	the	DT
cord-305737-bnzd7b25	147	21	role	role	NN
cord-305737-bnzd7b25	147	22	of	of	IN
cord-305737-bnzd7b25	147	23	these	these	DT
cord-305737-bnzd7b25	147	24	proteins	protein	NNS
cord-305737-bnzd7b25	147	25	in	in	IN
cord-305737-bnzd7b25	147	26	immune	immune	JJ
cord-305737-bnzd7b25	147	27	responses	response	NNS
cord-305737-bnzd7b25	147	28	to	to	IN
cord-305737-bnzd7b25	147	29	virus	virus	NN
cord-305737-bnzd7b25	147	30	infection	infection	NN
cord-305737-bnzd7b25	147	31	.	.	.
cord-305737-bnzd7b25	148	1	The	the	DT
cord-305737-bnzd7b25	148	2	IFN	IFN	NNP
cord-305737-bnzd7b25	148	3	system	system	NN
cord-305737-bnzd7b25	148	4	operates	operate	VBZ
cord-305737-bnzd7b25	148	5	in	in	IN
cord-305737-bnzd7b25	148	6	two	two	CD
cord-305737-bnzd7b25	148	7	phases	phase	NNS
cord-305737-bnzd7b25	148	8	:	:	:
cord-305737-bnzd7b25	148	9	first	first	RB
cord-305737-bnzd7b25	148	10	,	,	,
cord-305737-bnzd7b25	148	11	virus	virus	NN
cord-305737-bnzd7b25	148	12	presence	presence	NN
cord-305737-bnzd7b25	148	13	is	be	VBZ
cord-305737-bnzd7b25	148	14	detected	detect	VBN
cord-305737-bnzd7b25	148	15	,	,	,
cord-305737-bnzd7b25	148	16	resulting	result	VBG
cord-305737-bnzd7b25	148	17	in	in	IN
cord-305737-bnzd7b25	148	18	the	the	DT
cord-305737-bnzd7b25	148	19	expression	expression	NN
cord-305737-bnzd7b25	148	20	of	of	IN
cord-305737-bnzd7b25	148	21	IFN	IFN	NNP
cord-305737-bnzd7b25	148	22	;	;	:
cord-305737-bnzd7b25	148	23	second	second	RB
cord-305737-bnzd7b25	148	24	,	,	,
cord-305737-bnzd7b25	148	25	IFN	IFN	NNP
cord-305737-bnzd7b25	148	26	induces	induce	VBZ
cord-305737-bnzd7b25	148	27	ISGs	isg	NNS
cord-305737-bnzd7b25	148	28	that	that	WDT
cord-305737-bnzd7b25	148	29	exert	exert	VBP
cord-305737-bnzd7b25	148	30	anti	anti	JJ
cord-305737-bnzd7b25	148	31	-	-	JJ
cord-305737-bnzd7b25	148	32	viral	viral	JJ
cord-305737-bnzd7b25	148	33	effects	effect	NNS
cord-305737-bnzd7b25	148	34	(	(	-LRB-
cord-305737-bnzd7b25	148	35	Figure	figure	NN
cord-305737-bnzd7b25	148	36	1	1	CD
cord-305737-bnzd7b25	148	37	)	)	-RRB-
cord-305737-bnzd7b25	148	38	.	.	.
cord-305737-bnzd7b25	149	1	Recent	recent	JJ
cord-305737-bnzd7b25	149	2	work	work	NN
cord-305737-bnzd7b25	149	3	shows	show	VBZ
cord-305737-bnzd7b25	149	4	that	that	IN
cord-305737-bnzd7b25	149	5	the	the	DT
cord-305737-bnzd7b25	149	6	IFN	IFN	NNP
cord-305737-bnzd7b25	149	7	system	system	NN
cord-305737-bnzd7b25	149	8	targets	target	VBZ
cord-305737-bnzd7b25	149	9	5PPP	5ppp	CD
cord-305737-bnzd7b25	149	10	RNAs	rna	NNS
cord-305737-bnzd7b25	149	11	during	during	IN
cord-305737-bnzd7b25	149	12	both	both	DT
cord-305737-bnzd7b25	149	13	phases	phase	NNS
cord-305737-bnzd7b25	149	14	:	:	:
cord-305737-bnzd7b25	149	15	both	both	CC
cord-305737-bnzd7b25	149	16	RIG	rig	NN
cord-305737-bnzd7b25	149	17	-	-	:
cord-305737-bnzd7b25	149	18	I	I	NNP
cord-305737-bnzd7b25	149	19	,	,	,
cord-305737-bnzd7b25	149	20	a	a	DT
cord-305737-bnzd7b25	149	21	virus	virus	NN
cord-305737-bnzd7b25	149	22	sensor	sensor	NN
cord-305737-bnzd7b25	149	23	that	that	WDT
cord-305737-bnzd7b25	149	24	induces	induce	VBZ
cord-305737-bnzd7b25	149	25	IFN	IFN	NNP
cord-305737-bnzd7b25	149	26	expression	expression	NN
cord-305737-bnzd7b25	149	27	,	,	,
cord-305737-bnzd7b25	149	28	and	and	CC
cord-305737-bnzd7b25	149	29	IFITs	ifit	NNS
cord-305737-bnzd7b25	149	30	,	,	,
cord-305737-bnzd7b25	149	31	effector	effector	NN
cord-305737-bnzd7b25	149	32	molecules	molecule	NNS
cord-305737-bnzd7b25	149	33	that	that	WDT
cord-305737-bnzd7b25	149	34	execute	execute	VBP
cord-305737-bnzd7b25	149	35	anti	anti	JJ
cord-305737-bnzd7b25	149	36	-	-	JJ
cord-305737-bnzd7b25	149	37	viral	viral	JJ
cord-305737-bnzd7b25	149	38	activities	activity	NNS
cord-305737-bnzd7b25	149	39	,	,	,
cord-305737-bnzd7b25	149	40	can	can	MD
cord-305737-bnzd7b25	149	41	specifically	specifically	RB
cord-305737-bnzd7b25	149	42	recognize	recognize	VB
cord-305737-bnzd7b25	149	43	5PPP	5ppp	CD
cord-305737-bnzd7b25	149	44	RNAs	rna	NNS
cord-305737-bnzd7b25	149	45	.	.	.
cord-305737-bnzd7b25	150	1	As	as	IN
cord-305737-bnzd7b25	150	2	such	such	JJ
cord-305737-bnzd7b25	150	3	,	,	,
cord-305737-bnzd7b25	150	4	5PPP	5ppp	CD
cord-305737-bnzd7b25	150	5	RNAs	rna	NNS
cord-305737-bnzd7b25	150	6	appear	appear	VBP
cord-305737-bnzd7b25	150	7	to	to	TO
cord-305737-bnzd7b25	150	8	be	be	VB
cord-305737-bnzd7b25	150	9	Achilles	Achilles	NNP
cord-305737-bnzd7b25	150	10	'	'	POS
cord-305737-bnzd7b25	150	11	heel	heel	NN
cord-305737-bnzd7b25	150	12	of	of	IN
cord-305737-bnzd7b25	150	13	many	many	JJ
cord-305737-bnzd7b25	150	14	RNA	RNA	NNP
cord-305737-bnzd7b25	150	15	viruses	virus	NNS
cord-305737-bnzd7b25	150	16	in	in	IN
cord-305737-bnzd7b25	150	17	their	-PRON-	PRP$
cord-305737-bnzd7b25	150	18	interaction	interaction	NN
cord-305737-bnzd7b25	150	19	with	with	IN
cord-305737-bnzd7b25	150	20	the	the	DT
cord-305737-bnzd7b25	150	21	innate	innate	JJ
cord-305737-bnzd7b25	150	22	immune	immune	JJ
cord-305737-bnzd7b25	150	23	system	system	NN
cord-305737-bnzd7b25	150	24	(	(	-LRB-
cord-305737-bnzd7b25	150	25	Figure	figure	NN
cord-305737-bnzd7b25	150	26	3a	3a	CD
cord-305737-bnzd7b25	150	27	)	)	-RRB-
cord-305737-bnzd7b25	150	28	.	.	.
cord-305737-bnzd7b25	151	1	Why	why	WRB
cord-305737-bnzd7b25	151	2	is	be	VBZ
cord-305737-bnzd7b25	151	3	this	this	DT
cord-305737-bnzd7b25	151	4	the	the	DT
cord-305737-bnzd7b25	151	5	case	case	NN
cord-305737-bnzd7b25	151	6	?	?	.
cord-305737-bnzd7b25	152	1	Many	many	JJ
cord-305737-bnzd7b25	152	2	RNA	RNA	NNP
cord-305737-bnzd7b25	152	3	viruses	virus	NNS
cord-305737-bnzd7b25	152	4	use	use	VBP
cord-305737-bnzd7b25	152	5	primer	primer	NN
cord-305737-bnzd7b25	152	6	-	-	HYPH
cord-305737-bnzd7b25	152	7	independent	independent	JJ
cord-305737-bnzd7b25	152	8	means	mean	NNS
cord-305737-bnzd7b25	152	9	of	of	IN
cord-305737-bnzd7b25	152	10	replication	replication	NN
cord-305737-bnzd7b25	152	11	.	.	.
cord-305737-bnzd7b25	153	1	5PPP	5ppp	LS
cord-305737-bnzd7b25	153	2	moieties	moiety	NNS
cord-305737-bnzd7b25	153	3	on	on	IN
cord-305737-bnzd7b25	153	4	viral	viral	JJ
cord-305737-bnzd7b25	153	5	RNA	RNA	NNP
cord-305737-bnzd7b25	153	6	genomes	genome	NNS
cord-305737-bnzd7b25	153	7	,	,	,
cord-305737-bnzd7b25	153	8	antigenomes	antigenome	NNS
cord-305737-bnzd7b25	153	9	and	and	CC
cord-305737-bnzd7b25	153	10	some	some	DT
cord-305737-bnzd7b25	153	11	viral	viral	JJ
cord-305737-bnzd7b25	153	12	transcripts	transcript	NNS
cord-305737-bnzd7b25	153	13	are	be	VBP
cord-305737-bnzd7b25	153	14	an	an	DT
cord-305737-bnzd7b25	153	15	inevitable	inevitable	JJ
cord-305737-bnzd7b25	153	16	consequence	consequence	NN
cord-305737-bnzd7b25	153	17	of	of	IN
cord-305737-bnzd7b25	153	18	primer	primer	NN
cord-305737-bnzd7b25	153	19	-	-	HYPH
cord-305737-bnzd7b25	153	20	independent	independent	JJ
cord-305737-bnzd7b25	153	21	initiation	initiation	NN
cord-305737-bnzd7b25	153	22	of	of	IN
cord-305737-bnzd7b25	153	23	RNA	RNA	NNP
cord-305737-bnzd7b25	153	24	synthesis	synthesis	NN
cord-305737-bnzd7b25	153	25	by	by	IN
cord-305737-bnzd7b25	153	26	a	a	DT
cord-305737-bnzd7b25	153	27	single	single	JJ
cord-305737-bnzd7b25	153	28	ribonucleoside	ribonucleoside	NN
cord-305737-bnzd7b25	153	29	-	-	HYPH
cord-305737-bnzd7b25	153	30	triphosphate	triphosphate	NN
cord-305737-bnzd7b25	153	31	[	[	-LRB-
cord-305737-bnzd7b25	153	32	51	51	CD
cord-305737-bnzd7b25	153	33	]	]	-RRB-
cord-305737-bnzd7b25	153	34	.	.	.
cord-305737-bnzd7b25	154	1	The	the	DT
cord-305737-bnzd7b25	154	2	fundamental	fundamental	JJ
cord-305737-bnzd7b25	154	3	importance	importance	NN
cord-305737-bnzd7b25	154	4	of	of	IN
cord-305737-bnzd7b25	154	5	RNA	RNA	NNP
cord-305737-bnzd7b25	154	6	replication	replication	NN
cord-305737-bnzd7b25	154	7	to	to	IN
cord-305737-bnzd7b25	154	8	the	the	DT
cord-305737-bnzd7b25	154	9	life	life	NN
cord-305737-bnzd7b25	154	10	cycle	cycle	NN
cord-305737-bnzd7b25	154	11	of	of	IN
cord-305737-bnzd7b25	154	12	RNA	RNA	NNP
cord-305737-bnzd7b25	154	13	viruses	virus	NNS
cord-305737-bnzd7b25	154	14	may	may	MD
cord-305737-bnzd7b25	154	15	explain	explain	VB
cord-305737-bnzd7b25	154	16	why	why	WRB
cord-305737-bnzd7b25	154	17	viruses	virus	NNS
cord-305737-bnzd7b25	154	18	that	that	WDT
cord-305737-bnzd7b25	154	19	use	use	VBP
cord-305737-bnzd7b25	154	20	primer	primer	NN
cord-305737-bnzd7b25	154	21	-	-	JJ
cord-305737-bnzd7b25	154	22	independent	independent	JJ
cord-305737-bnzd7b25	154	23	strategies	strategy	NNS
cord-305737-bnzd7b25	154	24	to	to	TO
cord-305737-bnzd7b25	154	25	initiate	initiate	VB
cord-305737-bnzd7b25	154	26	RNA	RNA	NNP
cord-305737-bnzd7b25	154	27	synthesis	synthesis	NN
cord-305737-bnzd7b25	154	28	have	have	VBP
cord-305737-bnzd7b25	154	29	been	be	VBN
cord-305737-bnzd7b25	154	30	forced	force	VBN
cord-305737-bnzd7b25	154	31	to	to	TO
cord-305737-bnzd7b25	154	32	maintain	maintain	VB
cord-305737-bnzd7b25	154	33	5PPP	5ppp	CD
cord-305737-bnzd7b25	154	34	groups	group	NNS
cord-305737-bnzd7b25	154	35	during	during	IN
cord-305737-bnzd7b25	154	36	evolution	evolution	NN
cord-305737-bnzd7b25	154	37	-despite	-despite	CD
cord-305737-bnzd7b25	155	1	the	the	DT
cord-305737-bnzd7b25	155	2	selective	selective	JJ
cord-305737-bnzd7b25	155	3	pressure	pressure	NN
cord-305737-bnzd7b25	155	4	exerted	exert	VBN
cord-305737-bnzd7b25	155	5	by	by	IN
cord-305737-bnzd7b25	155	6	the	the	DT
cord-305737-bnzd7b25	155	7	IFN	IFN	NNP
cord-305737-bnzd7b25	155	8	system	system	NN
cord-305737-bnzd7b25	155	9	that	that	WDT
cord-305737-bnzd7b25	155	10	detects	detect	VBZ
cord-305737-bnzd7b25	155	11	these	these	DT
cord-305737-bnzd7b25	155	12	moieties	moiety	NNS
cord-305737-bnzd7b25	155	13	.	.	.
cord-305737-bnzd7b25	156	1	It	-PRON-	PRP
cord-305737-bnzd7b25	156	2	is	be	VBZ
cord-305737-bnzd7b25	156	3	noteworthy	noteworthy	JJ
cord-305737-bnzd7b25	156	4	that	that	IN
cord-305737-bnzd7b25	156	5	other	other	JJ
cord-305737-bnzd7b25	156	6	mechanisms	mechanism	NNS
cord-305737-bnzd7b25	156	7	to	to	TO
cord-305737-bnzd7b25	156	8	initiate	initiate	VB
cord-305737-bnzd7b25	156	9	RNA	RNA	NNP
cord-305737-bnzd7b25	156	10	synthesis	synthesis	NN
cord-305737-bnzd7b25	156	11	and	and	CC
cord-305737-bnzd7b25	156	12	the	the	DT
cord-305737-bnzd7b25	156	13	removal	removal	NN
cord-305737-bnzd7b25	156	14	of	of	IN
cord-305737-bnzd7b25	156	15	5PPP	5ppp	CD
cord-305737-bnzd7b25	156	16	groups	group	NNS
cord-305737-bnzd7b25	156	17	have	have	VBP
cord-305737-bnzd7b25	156	18	evolved	evolve	VBN
cord-305737-bnzd7b25	156	19	in	in	IN
cord-305737-bnzd7b25	156	20	some	some	DT
cord-305737-bnzd7b25	156	21	virus	virus	NN
cord-305737-bnzd7b25	156	22	families	family	NNS
cord-305737-bnzd7b25	156	23	.	.	.
cord-305737-bnzd7b25	157	1	For	for	IN
cord-305737-bnzd7b25	157	2	example	example	NN
cord-305737-bnzd7b25	157	3	,	,	,
cord-305737-bnzd7b25	157	4	EMCV	EMCV	NNP
cord-305737-bnzd7b25	157	5	uses	use	VBZ
cord-305737-bnzd7b25	157	6	as	as	IN
cord-305737-bnzd7b25	157	7	primer	primer	NN
cord-305737-bnzd7b25	157	8	for	for	IN
cord-305737-bnzd7b25	157	9	RNA	RNA	NNP
cord-305737-bnzd7b25	157	10	replication	replication	NN
cord-305737-bnzd7b25	157	11	a	a	DT
cord-305737-bnzd7b25	157	12	protein	protein	NN
cord-305737-bnzd7b25	157	13	known	know	VBN
cord-305737-bnzd7b25	157	14	as	as	IN
cord-305737-bnzd7b25	157	15	VPg	VPg	NNS
cord-305737-bnzd7b25	157	16	,	,	,
cord-305737-bnzd7b25	157	17	which	which	WDT
cord-305737-bnzd7b25	157	18	becomes	become	VBZ
cord-305737-bnzd7b25	157	19	covalently	covalently	RB
cord-305737-bnzd7b25	157	20	attached	attach	VBN
cord-305737-bnzd7b25	157	21	to	to	IN
cord-305737-bnzd7b25	157	22	the	the	DT
cord-305737-bnzd7b25	157	23	5	5	CD
cord-305737-bnzd7b25	157	24	0	0	CD
cord-305737-bnzd7b25	158	1	-end	-end	:
cord-305737-bnzd7b25	158	2	of	of	IN
cord-305737-bnzd7b25	158	3	the	the	DT
cord-305737-bnzd7b25	158	4	viral	viral	JJ
cord-305737-bnzd7b25	158	5	genome	genome	NN
cord-305737-bnzd7b25	158	6	[	[	-LRB-
cord-305737-bnzd7b25	158	7	51	51	CD
cord-305737-bnzd7b25	158	8	]	]	-RRB-
cord-305737-bnzd7b25	158	9	.	.	.
cord-305737-bnzd7b25	159	1	Hantaan	Hantaan	NNP
cord-305737-bnzd7b25	159	2	virus	virus	NN
cord-305737-bnzd7b25	159	3	,	,	,
cord-305737-bnzd7b25	159	4	Crimean	Crimean	NNP
cord-305737-bnzd7b25	159	5	-	-	HYPH
cord-305737-bnzd7b25	159	6	Congo	Congo	NNP
cord-305737-bnzd7b25	159	7	haemorrhagic	haemorrhagic	JJ
cord-305737-bnzd7b25	159	8	fever	fever	NN
cord-305737-bnzd7b25	159	9	virus	virus	NN
cord-305737-bnzd7b25	159	10	and	and	CC
cord-305737-bnzd7b25	159	11	Borna	Borna	NNP
cord-305737-bnzd7b25	159	12	disease	disease	NN
cord-305737-bnzd7b25	159	13	virus	virus	NN
cord-305737-bnzd7b25	159	14	posttranscriptionally	posttranscriptionally	RB
cord-305737-bnzd7b25	159	15	process	process	VBP
cord-305737-bnzd7b25	159	16	the	the	DT
cord-305737-bnzd7b25	159	17	5	5	CD
cord-305737-bnzd7b25	159	18	0	0	CD
cord-305737-bnzd7b25	159	19	-end	-end	:
cord-305737-bnzd7b25	159	20	of	of	IN
cord-305737-bnzd7b25	159	21	their	-PRON-	PRP$
cord-305737-bnzd7b25	159	22	genomes	genome	NNS
cord-305737-bnzd7b25	159	23	to	to	TO
cord-305737-bnzd7b25	159	24	leave	leave	VB
cord-305737-bnzd7b25	159	25	a	a	DT
cord-305737-bnzd7b25	159	26	mono	mono	NN
cord-305737-bnzd7b25	159	27	-	-	HYPH
cord-305737-bnzd7b25	159	28	phosphate	phosphate	NN
cord-305737-bnzd7b25	159	29	[	[	-LRB-
cord-305737-bnzd7b25	159	30	52	52	CD
cord-305737-bnzd7b25	159	31	]	]	-RRB-
cord-305737-bnzd7b25	159	32	.	.	.
cord-305737-bnzd7b25	160	1	Consistent	consistent	JJ
cord-305737-bnzd7b25	160	2	with	with	IN
cord-305737-bnzd7b25	160	3	these	these	DT
cord-305737-bnzd7b25	160	4	facts	fact	NNS
cord-305737-bnzd7b25	160	5	,	,	,
cord-305737-bnzd7b25	160	6	none	none	NN
cord-305737-bnzd7b25	160	7	of	of	IN
cord-305737-bnzd7b25	160	8	these	these	DT
cord-305737-bnzd7b25	160	9	viruses	virus	NNS
cord-305737-bnzd7b25	160	10	trigger	trigger	VBP
cord-305737-bnzd7b25	160	11	IFN	IFN	NNP
cord-305737-bnzd7b25	160	12	induction	induction	NN
cord-305737-bnzd7b25	160	13	via	via	IN
cord-305737-bnzd7b25	160	14	RIG-	RIG-	NNP
cord-305737-bnzd7b25	161	1	I	-PRON-	PRP
cord-305737-bnzd7b25	161	2	and	and	CC
cord-305737-bnzd7b25	161	3	EMCV	EMCV	NNP
cord-305737-bnzd7b25	161	4	is	be	VBZ
cord-305737-bnzd7b25	161	5	not	not	RB
cord-305737-bnzd7b25	161	6	restricted	restrict	VBN
cord-305737-bnzd7b25	161	7	by	by	IN
cord-305737-bnzd7b25	161	8	IFIT1	ifit1	JJ
cord-305737-bnzd7b25	161	9	[	[	-LRB-
cord-305737-bnzd7b25	161	10	9	9	CD
cord-305737-bnzd7b25	161	11	,	,	,
cord-305737-bnzd7b25	161	12	38,52	38,52	CD
cord-305737-bnzd7b25	161	13	]	]	-RRB-
cord-305737-bnzd7b25	162	1	(	(	-LRB-
cord-305737-bnzd7b25	162	2	Table	table	NN
cord-305737-bnzd7b25	162	3	1	1	CD
cord-305737-bnzd7b25	162	4	)	)	-RRB-
cord-305737-bnzd7b25	162	5	.	.	.
cord-305737-bnzd7b25	163	1	Notably	notably	RB
cord-305737-bnzd7b25	163	2	,	,	,
cord-305737-bnzd7b25	163	3	viruses	virus	NNS
cord-305737-bnzd7b25	163	4	that	that	WDT
cord-305737-bnzd7b25	163	5	maintain	maintain	VBP
cord-305737-bnzd7b25	163	6	5PPP	5ppp	CD
cord-305737-bnzd7b25	163	7	RNA	RNA	NNP
cord-305737-bnzd7b25	163	8	and	and	CC
cord-305737-bnzd7b25	163	9	are	be	VBP
cord-305737-bnzd7b25	163	10	recognized	recognize	VBN
cord-305737-bnzd7b25	163	11	by	by	IN
cord-305737-bnzd7b25	163	12	RIG	rig	NN
cord-305737-bnzd7b25	163	13	-	-	:
cord-305737-bnzd7b25	163	14	I	-PRON-	PRP
cord-305737-bnzd7b25	163	15	often	often	RB
cord-305737-bnzd7b25	163	16	encode	encode	VBP
cord-305737-bnzd7b25	163	17	proteins	protein	NNS
cord-305737-bnzd7b25	163	18	that	that	WDT
cord-305737-bnzd7b25	163	19	specifically	specifically	RB
cord-305737-bnzd7b25	163	20	target	target	VBP
cord-305737-bnzd7b25	163	21	and	and	CC
cord-305737-bnzd7b25	163	22	inhibit	inhibit	VB
cord-305737-bnzd7b25	163	23	RLR	RLR	NNP
cord-305737-bnzd7b25	163	24	signalling	signal	VBG
cord-305737-bnzd7b25	163	25	[	[	-LRB-
cord-305737-bnzd7b25	163	26	53	53	CD
cord-305737-bnzd7b25	163	27	]	]	-RRB-
cord-305737-bnzd7b25	163	28	.	.	.
cord-305737-bnzd7b25	164	1	Studies	study	NNS
cord-305737-bnzd7b25	164	2	of	of	IN
cord-305737-bnzd7b25	164	3	the	the	DT
cord-305737-bnzd7b25	164	4	sensors	sensor	NNS
cord-305737-bnzd7b25	164	5	that	that	WDT
cord-305737-bnzd7b25	164	6	detect	detect	VBP
cord-305737-bnzd7b25	164	7	RNA	RNA	NNP
cord-305737-bnzd7b25	164	8	viruses	virus	NNS
cord-305737-bnzd7b25	164	9	and	and	CC
cord-305737-bnzd7b25	164	10	the	the	DT
cord-305737-bnzd7b25	164	11	identification	identification	NN
cord-305737-bnzd7b25	164	12	of	of	IN
cord-305737-bnzd7b25	164	13	ISGs	isg	NNS
cord-305737-bnzd7b25	164	14	that	that	WDT
cord-305737-bnzd7b25	164	15	restrict	restrict	VBP
cord-305737-bnzd7b25	164	16	them	-PRON-	PRP
cord-305737-bnzd7b25	164	17	remain	remain	VB
cord-305737-bnzd7b25	164	18	challenges	challenge	NNS
cord-305737-bnzd7b25	164	19	for	for	IN
cord-305737-bnzd7b25	164	20	the	the	DT
cord-305737-bnzd7b25	164	21	future	future	NN
cord-305737-bnzd7b25	164	22	.	.	.
cord-305737-bnzd7b25	165	1	Papers	paper	NNS
cord-305737-bnzd7b25	165	2	of	of	IN
cord-305737-bnzd7b25	165	3	particular	particular	JJ
cord-305737-bnzd7b25	165	4	interest	interest	NN
cord-305737-bnzd7b25	165	5	,	,	,
cord-305737-bnzd7b25	165	6	published	publish	VBN
cord-305737-bnzd7b25	165	7	within	within	IN
cord-305737-bnzd7b25	165	8	the	the	DT
cord-305737-bnzd7b25	165	9	period	period	NN
cord-305737-bnzd7b25	165	10	of	of	IN
cord-305737-bnzd7b25	165	11	review	review	NN
cord-305737-bnzd7b25	165	12	,	,	,
cord-305737-bnzd7b25	165	13	have	have	VBP
cord-305737-bnzd7b25	165	14	been	be	VBN
cord-305737-bnzd7b25	165	15	highlighted	highlight	VBN
cord-305737-bnzd7b25	165	16	as	as	IN
cord-305737-bnzd7b25	165	17	:	:	:
cord-305737-bnzd7b25	165	18	of	of	IN
cord-305737-bnzd7b25	165	19	special	special	JJ
cord-305737-bnzd7b25	165	20	interest	interest	NN
cord-305737-bnzd7b25	165	21	of	of	IN
cord-305737-bnzd7b25	165	22	outstanding	outstanding	JJ
cord-305737-bnzd7b25	165	23	interest	interest	NN
cord-305737-bnzd7b25	165	24	Virus	Virus	NNP
cord-305737-bnzd7b25	165	25	interference	interference	NN
cord-305737-bnzd7b25	165	26	.	.	.
cord-305737-bnzd7b25	166	1	I.	I.	NNP
cord-305737-bnzd7b25	167	1	The	the	DT
cord-305737-bnzd7b25	167	2	interferon	interferon	NN
cord-305737-bnzd7b25	167	3	Interferons	Interferons	NNPS
cord-305737-bnzd7b25	167	4	,	,	,
cord-305737-bnzd7b25	167	5	interferon	interferon	NN
cord-305737-bnzd7b25	167	6	-	-	HYPH
cord-305737-bnzd7b25	167	7	like	like	JJ
cord-305737-bnzd7b25	167	8	cytokines	cytokine	NNS
cord-305737-bnzd7b25	167	9	,	,	,
cord-305737-bnzd7b25	167	10	and	and	CC
cord-305737-bnzd7b25	167	11	their	-PRON-	PRP$
cord-305737-bnzd7b25	167	12	receptors	receptor	NNS
cord-305737-bnzd7b25	168	1	Innate	innate	JJ
cord-305737-bnzd7b25	168	2	recognition	recognition	NN
cord-305737-bnzd7b25	168	3	of	of	IN
cord-305737-bnzd7b25	168	4	viruses	virus	NNS
cord-305737-bnzd7b25	169	1	Type	type	NN
cord-305737-bnzd7b25	170	1	I	-PRON-	PRP
cord-305737-bnzd7b25	170	2	interferonopathies	interferonopathie	VBZ
cord-305737-bnzd7b25	170	3	:	:	:
cord-305737-bnzd7b25	171	1	a	a	DT
cord-305737-bnzd7b25	171	2	novel	novel	NN
cord-305737-bnzd7b25	171	3	set	set	NN
cord-305737-bnzd7b25	171	4	of	of	IN
cord-305737-bnzd7b25	171	5	inborn	inborn	JJ
cord-305737-bnzd7b25	171	6	errors	error	NNS
cord-305737-bnzd7b25	171	7	of	of	IN
cord-305737-bnzd7b25	171	8	immunity	immunity	NN
cord-305737-bnzd7b25	171	9	A	a	DT
cord-305737-bnzd7b25	171	10	diverse	diverse	JJ
cord-305737-bnzd7b25	171	11	range	range	NN
cord-305737-bnzd7b25	171	12	of	of	IN
cord-305737-bnzd7b25	171	13	gene	gene	NN
cord-305737-bnzd7b25	171	14	products	product	NNS
cord-305737-bnzd7b25	171	15	are	be	VBP
cord-305737-bnzd7b25	171	16	effectors	effector	NNS
cord-305737-bnzd7b25	171	17	of	of	IN
cord-305737-bnzd7b25	171	18	the	the	DT
cord-305737-bnzd7b25	171	19	type	type	NN
cord-305737-bnzd7b25	172	1	I	-PRON-	PRP
cord-305737-bnzd7b25	172	2	interferon	interferon	VBP
cord-305737-bnzd7b25	172	3	antiviral	antiviral	JJ
cord-305737-bnzd7b25	172	4	response	response	NN
cord-305737-bnzd7b25	173	1	The	the	DT
cord-305737-bnzd7b25	173	2	ISG56	ISG56	NNP
cord-305737-bnzd7b25	173	3	/	/	SYM
cord-305737-bnzd7b25	173	4	IFIT1	ifit1	JJ
cord-305737-bnzd7b25	173	5	gene	gene	NN
cord-305737-bnzd7b25	173	6	family	family	NN
cord-305737-bnzd7b25	174	1	The	the	DT
cord-305737-bnzd7b25	174	2	broad	broad	JJ
cord-305737-bnzd7b25	174	3	-	-	HYPH
cord-305737-bnzd7b25	174	4	spectrum	spectrum	NN
cord-305737-bnzd7b25	174	5	antiviral	antiviral	JJ
cord-305737-bnzd7b25	174	6	functions	function	NNS
cord-305737-bnzd7b25	174	7	of	of	IN
cord-305737-bnzd7b25	174	8	IFIT	IFIT	NNP
cord-305737-bnzd7b25	174	9	and	and	CC
cord-305737-bnzd7b25	174	10	IFITM	IFITM	NNP
cord-305737-bnzd7b25	174	11	proteins	protein	NNS
cord-305737-bnzd7b25	175	1	Structural	structural	JJ
cord-305737-bnzd7b25	175	2	basis	basis	NN
cord-305737-bnzd7b25	175	3	for	for	IN
cord-305737-bnzd7b25	175	4	viral	viral	JJ
cord-305737-bnzd7b25	175	5	5	5	CD
cord-305737-bnzd7b25	175	6	0	0	CD
cord-305737-bnzd7b25	175	7	-PPP	-PPP	:
cord-305737-bnzd7b25	175	8	-	-	HYPH
cord-305737-bnzd7b25	175	9	RNA	rna	NN
cord-305737-bnzd7b25	175	10	recognition	recognition	NN
cord-305737-bnzd7b25	175	11	by	by	IN
cord-305737-bnzd7b25	175	12	human	human	JJ
cord-305737-bnzd7b25	175	13	IFIT	ifit	NN
cord-305737-bnzd7b25	175	14	proteins	protein	NNS
cord-305737-bnzd7b25	176	1	This	this	DT
cord-305737-bnzd7b25	176	2	study	study	NN
cord-305737-bnzd7b25	176	3	reveals	reveal	VBZ
cord-305737-bnzd7b25	176	4	the	the	DT
cord-305737-bnzd7b25	176	5	structural	structural	JJ
cord-305737-bnzd7b25	176	6	basis	basis	NN
cord-305737-bnzd7b25	176	7	of	of	IN
cord-305737-bnzd7b25	176	8	how	how	WRB
cord-305737-bnzd7b25	176	9	IFITs	ifit	NNS
cord-305737-bnzd7b25	176	10	interact	interact	VBP
cord-305737-bnzd7b25	176	11	with	with	IN
cord-305737-bnzd7b25	176	12	5PPP	5ppp	CD
cord-305737-bnzd7b25	176	13	RNA	RNA	NNP
cord-305737-bnzd7b25	176	14	IFIT1	ifit1	NN
cord-305737-bnzd7b25	176	15	is	be	VBZ
cord-305737-bnzd7b25	176	16	an	an	DT
cord-305737-bnzd7b25	176	17	antiviral	antiviral	JJ
cord-305737-bnzd7b25	176	18	protein	protein	NN
cord-305737-bnzd7b25	176	19	that	that	WDT
cord-305737-bnzd7b25	176	20	recognizes	recognize	VBZ
cord-305737-bnzd7b25	176	21	5	5	CD
cord-305737-bnzd7b25	176	22	0	0	CD
cord-305737-bnzd7b25	176	23	-triphosphate	-triphosphate	.
cord-305737-bnzd7b25	177	1	RNA	RNA	NNP
cord-305737-bnzd7b25	177	2	RIGorous	RIGorous	NNP
cord-305737-bnzd7b25	177	3	detection	detection	NN
cord-305737-bnzd7b25	177	4	:	:	:
cord-305737-bnzd7b25	178	1	exposing	expose	VBG
cord-305737-bnzd7b25	178	2	virus	virus	NN
cord-305737-bnzd7b25	178	3	through	through	IN
cord-305737-bnzd7b25	178	4	RNA	RNA	NNP
cord-305737-bnzd7b25	178	5	sensing	sense	VBG
cord-305737-bnzd7b25	178	6	The	the	DT
cord-305737-bnzd7b25	178	7	chase	chase	NN
cord-305737-bnzd7b25	178	8	for	for	IN
cord-305737-bnzd7b25	178	9	the	the	DT
cord-305737-bnzd7b25	178	10	RIG-	RIG-	NNP
cord-305737-bnzd7b25	179	1	I	-PRON-	PRP
cord-305737-bnzd7b25	180	1	ligand	ligand	NNP
cord-305737-bnzd7b25	180	2	-recent	-recent	VBD
cord-305737-bnzd7b25	180	3	advances	advance	NNS
cord-305737-bnzd7b25	181	1	Preference	preference	NN
cord-305737-bnzd7b25	181	2	of	of	IN
cord-305737-bnzd7b25	181	3	RIG	rig	NN
cord-305737-bnzd7b25	181	4	-	-	:
cord-305737-bnzd7b25	181	5	I	-PRON-	PRP
cord-305737-bnzd7b25	181	6	for	for	IN
cord-305737-bnzd7b25	181	7	short	short	JJ
cord-305737-bnzd7b25	181	8	viral	viral	JJ
cord-305737-bnzd7b25	181	9	RNA	RNA	NNP
cord-305737-bnzd7b25	181	10	molecules	molecule	NNS
cord-305737-bnzd7b25	181	11	in	in	IN
cord-305737-bnzd7b25	181	12	infected	infected	JJ
cord-305737-bnzd7b25	181	13	cells	cell	NNS
cord-305737-bnzd7b25	181	14	revealed	reveal	VBN
cord-305737-bnzd7b25	181	15	by	by	IN
cord-305737-bnzd7b25	181	16	next	next	JJ
cord-305737-bnzd7b25	181	17	-	-	HYPH
cord-305737-bnzd7b25	181	18	generation	generation	NN
cord-305737-bnzd7b25	181	19	sequencing	sequencing	NN
cord-305737-bnzd7b25	181	20	RIG	rig	NN
cord-305737-bnzd7b25	182	1	-I	-I	NNP
cord-305737-bnzd7b25	182	2	detects	detect	VBZ
cord-305737-bnzd7b25	182	3	viral	viral	JJ
cord-305737-bnzd7b25	182	4	genomic	genomic	JJ
cord-305737-bnzd7b25	182	5	RNA	RNA	NNP
cord-305737-bnzd7b25	182	6	during	during	IN
cord-305737-bnzd7b25	182	7	negative	negative	JJ
cord-305737-bnzd7b25	182	8	-	-	HYPH
cord-305737-bnzd7b25	182	9	strand	strand	NN
cord-305737-bnzd7b25	182	10	RNA	RNA	NNP
cord-305737-bnzd7b25	182	11	virus	virus	NN
cord-305737-bnzd7b25	182	12	infection	infection	NN
cord-305737-bnzd7b25	182	13	Incoming	Incoming	NNP
cord-305737-bnzd7b25	182	14	RNA	RNA	NNP
cord-305737-bnzd7b25	182	15	virus	virus	NN
cord-305737-bnzd7b25	182	16	nucleocapsids	nucleocapsid	NNS
cord-305737-bnzd7b25	182	17	containing	contain	VBG
cord-305737-bnzd7b25	182	18	a	a	DT
cord-305737-bnzd7b25	182	19	5	5	CD
cord-305737-bnzd7b25	182	20	0	0	CD
cord-305737-bnzd7b25	182	21	-triphosphorylated	-triphosphorylate	VBN
cord-305737-bnzd7b25	182	22	genome	genome	NN
cord-305737-bnzd7b25	182	23	activate	activate	VBP
cord-305737-bnzd7b25	182	24	RIG	rig	NN
cord-305737-bnzd7b25	182	25	-	-	:
cord-305737-bnzd7b25	182	26	I	i	NN
cord-305737-bnzd7b25	182	27	and	and	CC
cord-305737-bnzd7b25	182	28	antiviral	antiviral	JJ
cord-305737-bnzd7b25	182	29	signaling	signal	VBG
cord-305737-bnzd7b25	182	30	This	this	DT
cord-305737-bnzd7b25	182	31	study	study	NN
cord-305737-bnzd7b25	182	32	reports	report	VBZ
cord-305737-bnzd7b25	182	33	that	that	IN
cord-305737-bnzd7b25	182	34	RIG	rig	NN
cord-305737-bnzd7b25	182	35	-	-	:
cord-305737-bnzd7b25	182	36	I	-PRON-	PRP
cord-305737-bnzd7b25	182	37	is	be	VBZ
cord-305737-bnzd7b25	182	38	activated	activate	VBN
cord-305737-bnzd7b25	182	39	by	by	IN
cord-305737-bnzd7b25	182	40	bunyavirus	bunyavirus	NNP
cord-305737-bnzd7b25	182	41	5PPP	5PPP	NNP
cord-305737-bnzd7b25	182	42	RNA	RNA	NNP
cord-305737-bnzd7b25	182	43	genomes	genome	NNS
cord-305737-bnzd7b25	182	44	contained	contain	VBN
cord-305737-bnzd7b25	182	45	in	in	IN
cord-305737-bnzd7b25	182	46	nucleocapsids	nucleocapsid	NNS
cord-305737-bnzd7b25	182	47	,	,	,
cord-305737-bnzd7b25	182	48	which	which	WDT
cord-305737-bnzd7b25	182	49	demonstrates	demonstrate	VBZ
cord-305737-bnzd7b25	182	50	that	that	IN
cord-305737-bnzd7b25	182	51	this	this	DT
cord-305737-bnzd7b25	182	52	innate	innate	JJ
cord-305737-bnzd7b25	182	53	receptor	receptor	NN
cord-305737-bnzd7b25	182	54	can	can	MD
cord-305737-bnzd7b25	182	55	sense	sense	VB
cord-305737-bnzd7b25	182	56	viral	viral	JJ
cord-305737-bnzd7b25	182	57	RNA	RNA	NNP
cord-305737-bnzd7b25	182	58	in	in	IN
cord-305737-bnzd7b25	182	59	its	-PRON-	PRP$
cord-305737-bnzd7b25	182	60	native	native	JJ
cord-305737-bnzd7b25	182	61	complex	complex	NN
cord-305737-bnzd7b25	182	62	with	with	IN
cord-305737-bnzd7b25	182	63	viral	viral	JJ
cord-305737-bnzd7b25	182	64	proteins	protein	NNS
cord-305737-bnzd7b25	182	65	Mitochondrial	mitochondrial	JJ
cord-305737-bnzd7b25	182	66	antiviral	antiviral	JJ
cord-305737-bnzd7b25	182	67	signaling	signal	VBG
cord-305737-bnzd7b25	182	68	protein	protein	NN
cord-305737-bnzd7b25	182	69	(	(	-LRB-
cord-305737-bnzd7b25	182	70	MAVS	MAVS	NNP
cord-305737-bnzd7b25	182	71	)	)	-RRB-
cord-305737-bnzd7b25	182	72	monitors	monitor	VBZ
cord-305737-bnzd7b25	182	73	commensal	commensal	JJ
cord-305737-bnzd7b25	182	74	bacteria	bacteria	NNS
cord-305737-bnzd7b25	182	75	and	and	CC
cord-305737-bnzd7b25	182	76	induces	induce	VBZ
cord-305737-bnzd7b25	182	77	an	an	DT
cord-305737-bnzd7b25	182	78	immune	immune	JJ
cord-305737-bnzd7b25	182	79	response	response	NN
cord-305737-bnzd7b25	182	80	that	that	WDT
cord-305737-bnzd7b25	182	81	prevents	prevent	VBZ
cord-305737-bnzd7b25	182	82	experimental	experimental	JJ
cord-305737-bnzd7b25	182	83	colitis	colitis	NN
cord-305737-bnzd7b25	182	84	RIG	rig	NN
cord-305737-bnzd7b25	182	85	-	-	:
cord-305737-bnzd7b25	182	86	I	-PRON-	PRP
cord-305737-bnzd7b25	182	87	detects	detect	VBZ
cord-305737-bnzd7b25	182	88	infection	infection	NN
cord-305737-bnzd7b25	182	89	with	with	IN
cord-305737-bnzd7b25	182	90	live	live	JJ
cord-305737-bnzd7b25	182	91	Listeria	Listeria	NNP
cord-305737-bnzd7b25	182	92	by	by	IN
cord-305737-bnzd7b25	182	93	sensing	sense	VBG
cord-305737-bnzd7b25	182	94	secreted	secrete	VBN
cord-305737-bnzd7b25	182	95	bacterial	bacterial	JJ
cord-305737-bnzd7b25	182	96	nucleic	nucleic	JJ
cord-305737-bnzd7b25	182	97	acids	acid	NNS
cord-305737-bnzd7b25	182	98	Nonself	Nonself	NNP
cord-305737-bnzd7b25	182	99	RNA	RNA	NNP
cord-305737-bnzd7b25	182	100	-	-	HYPH
cord-305737-bnzd7b25	182	101	sensing	sense	VBG
cord-305737-bnzd7b25	182	102	mechanism	mechanism	NN
cord-305737-bnzd7b25	182	103	of	of	IN
cord-305737-bnzd7b25	182	104	RIG-	RIG-	NNP
cord-305737-bnzd7b25	183	1	I	-PRON-	PRP
cord-305737-bnzd7b25	183	2	helicase	helicase	VBD
cord-305737-bnzd7b25	183	3	and	and	CC
cord-305737-bnzd7b25	183	4	activation	activation	NN
cord-305737-bnzd7b25	183	5	of	of	IN
cord-305737-bnzd7b25	183	6	antiviral	antiviral	JJ
cord-305737-bnzd7b25	183	7	immune	immune	JJ
cord-305737-bnzd7b25	183	8	responses	response	NNS
cord-305737-bnzd7b25	184	1	A	a	DT
cord-305737-bnzd7b25	184	2	structural	structural	JJ
cord-305737-bnzd7b25	184	3	basis	basis	NN
cord-305737-bnzd7b25	184	4	for	for	IN
cord-305737-bnzd7b25	184	5	discriminating	discriminate	VBG
cord-305737-bnzd7b25	184	6	between	between	IN
cord-305737-bnzd7b25	184	7	self	self	NN
cord-305737-bnzd7b25	184	8	and	and	CC
cord-305737-bnzd7b25	184	9	nonself	nonself	NN
cord-305737-bnzd7b25	184	10	double	double	RB
cord-305737-bnzd7b25	184	11	-	-	HYPH
cord-305737-bnzd7b25	184	12	stranded	strand	VBN
cord-305737-bnzd7b25	184	13	RNAs	rna	NNS
cord-305737-bnzd7b25	184	14	in	in	IN
cord-305737-bnzd7b25	184	15	mammalian	mammalian	JJ
cord-305737-bnzd7b25	184	16	cells	cell	NNS
cord-305737-bnzd7b25	184	17	Lengthdependent	Lengthdependent	NNP
cord-305737-bnzd7b25	184	18	recognition	recognition	NN
cord-305737-bnzd7b25	184	19	of	of	IN
cord-305737-bnzd7b25	184	20	double	double	RB
cord-305737-bnzd7b25	184	21	-	-	HYPH
cord-305737-bnzd7b25	184	22	stranded	strand	VBN
cord-305737-bnzd7b25	184	23	ribonucleic	ribonucleic	JJ
cord-305737-bnzd7b25	184	24	acids	acid	NNS
cord-305737-bnzd7b25	184	25	by	by	IN
cord-305737-bnzd7b25	184	26	retinoic	retinoic	JJ
cord-305737-bnzd7b25	184	27	acid	acid	NN
cord-305737-bnzd7b25	184	28	-	-	HYPH
cord-305737-bnzd7b25	184	29	inducible	inducible	JJ
cord-305737-bnzd7b25	184	30	gene	gene	NN
cord-305737-bnzd7b25	184	31	-	-	:
cord-305737-bnzd7b25	184	32	I	i	NN
cord-305737-bnzd7b25	184	33	and	and	CC
cord-305737-bnzd7b25	184	34	melanoma	melanoma	NN
cord-305737-bnzd7b25	184	35	differentiationassociated	differentiationassociate	VBD
cord-305737-bnzd7b25	184	36	gene	gene	NN
cord-305737-bnzd7b25	184	37	5	5	CD
cord-305737-bnzd7b25	184	38	Molecular	Molecular	NNP
cord-305737-bnzd7b25	184	39	mechanism	mechanism	NN
cord-305737-bnzd7b25	184	40	of	of	IN
cord-305737-bnzd7b25	184	41	signal	signal	JJ
cord-305737-bnzd7b25	184	42	perception	perception	NN
cord-305737-bnzd7b25	184	43	and	and	CC
cord-305737-bnzd7b25	184	44	integration	integration	NN
cord-305737-bnzd7b25	184	45	by	by	IN
cord-305737-bnzd7b25	184	46	the	the	DT
cord-305737-bnzd7b25	184	47	innate	innate	JJ
cord-305737-bnzd7b25	184	48	immune	immune	JJ
cord-305737-bnzd7b25	184	49	sensor	sensor	NN
cord-305737-bnzd7b25	184	50	retinoic	retinoic	JJ
cord-305737-bnzd7b25	184	51	acid	acid	NN
cord-305737-bnzd7b25	184	52	-	-	HYPH
cord-305737-bnzd7b25	184	53	inducible	inducible	JJ
cord-305737-bnzd7b25	184	54	gene-	gene-	NN
cord-305737-bnzd7b25	185	1	I	-PRON-	PRP
cord-305737-bnzd7b25	185	2	(	(	-LRB-
cord-305737-bnzd7b25	185	3	RIG	rig	NN
cord-305737-bnzd7b25	185	4	-	-	:
cord-305737-bnzd7b25	185	5	I	i	NN
cord-305737-bnzd7b25	185	6	)	)	-RRB-
cord-305737-bnzd7b25	185	7	Reconstitution	reconstitution	NN
cord-305737-bnzd7b25	185	8	of	of	IN
cord-305737-bnzd7b25	185	9	the	the	DT
cord-305737-bnzd7b25	185	10	RIG	rig	NN
cord-305737-bnzd7b25	185	11	-	-	:
cord-305737-bnzd7b25	185	12	I	-PRON-	PRP
cord-305737-bnzd7b25	185	13	pathway	pathway	NN
cord-305737-bnzd7b25	185	14	reveals	reveal	VBZ
cord-305737-bnzd7b25	185	15	a	a	DT
cord-305737-bnzd7b25	185	16	signaling	signal	VBG
cord-305737-bnzd7b25	185	17	role	role	NN
cord-305737-bnzd7b25	185	18	of	of	IN
cord-305737-bnzd7b25	185	19	unanchored	unanchored	JJ
cord-305737-bnzd7b25	185	20	polyubiquitin	polyubiquitin	NNS
cord-305737-bnzd7b25	185	21	chains	chain	NNS
cord-305737-bnzd7b25	185	22	in	in	IN
cord-305737-bnzd7b25	185	23	innate	innate	JJ
cord-305737-bnzd7b25	185	24	immunity	immunity	NN
cord-305737-bnzd7b25	185	25	A	a	DT
cord-305737-bnzd7b25	185	26	structure	structure	NN
cord-305737-bnzd7b25	185	27	-	-	HYPH
cord-305737-bnzd7b25	185	28	based	base	VBN
cord-305737-bnzd7b25	185	29	model	model	NN
cord-305737-bnzd7b25	185	30	of	of	IN
cord-305737-bnzd7b25	185	31	RIG-	RIG-	NNP
cord-305737-bnzd7b25	186	1	I	-PRON-	PRP
cord-305737-bnzd7b25	186	2	activation	activation	VBP
cord-305737-bnzd7b25	186	3	Structural	structural	JJ
cord-305737-bnzd7b25	186	4	insights	insight	NNS
cord-305737-bnzd7b25	186	5	into	into	IN
cord-305737-bnzd7b25	186	6	the	the	DT
cord-305737-bnzd7b25	186	7	activation	activation	NN
cord-305737-bnzd7b25	186	8	of	of	IN
cord-305737-bnzd7b25	186	9	RIG	rig	NN
cord-305737-bnzd7b25	186	10	-	-	:
cord-305737-bnzd7b25	186	11	I	I	NNP
cord-305737-bnzd7b25	186	12	,	,	,
cord-305737-bnzd7b25	186	13	a	a	DT
cord-305737-bnzd7b25	186	14	nanosensor	nanosensor	NN
cord-305737-bnzd7b25	186	15	for	for	IN
cord-305737-bnzd7b25	186	16	viral	viral	JJ
cord-305737-bnzd7b25	186	17	RNAs	rna	NNS
cord-305737-bnzd7b25	187	1	The	the	DT
cord-305737-bnzd7b25	187	2	Cterminal	Cterminal	NNP
cord-305737-bnzd7b25	187	3	regulatory	regulatory	JJ
cord-305737-bnzd7b25	187	4	domain	domain	NN
cord-305737-bnzd7b25	187	5	is	be	VBZ
cord-305737-bnzd7b25	187	6	the	the	DT
cord-305737-bnzd7b25	187	7	RNA	RNA	NNP
cord-305737-bnzd7b25	187	8	5	5	CD
cord-305737-bnzd7b25	187	9	0	0	CD
cord-305737-bnzd7b25	187	10	-triphosphate	-triphosphate	NN
cord-305737-bnzd7b25	187	11	sensor	sensor	NN
cord-305737-bnzd7b25	187	12	of	of	IN
cord-305737-bnzd7b25	187	13	RIG	rig	NN
cord-305737-bnzd7b25	187	14	-	-	:
cord-305737-bnzd7b25	187	15	I	I	NNP
cord-305737-bnzd7b25	187	16	Structural	structural	JJ
cord-305737-bnzd7b25	187	17	and	and	CC
cord-305737-bnzd7b25	187	18	functional	functional	JJ
cord-305737-bnzd7b25	187	19	insights	insight	NNS
cord-305737-bnzd7b25	187	20	into	into	IN
cord-305737-bnzd7b25	187	21	5	5	CD
cord-305737-bnzd7b25	187	22	0	0	CD
cord-305737-bnzd7b25	188	1	-ppp	-ppp	:
cord-305737-bnzd7b25	189	1	RNA	RNA	NNP
cord-305737-bnzd7b25	189	2	pattern	pattern	NN
cord-305737-bnzd7b25	189	3	recognition	recognition	NN
cord-305737-bnzd7b25	189	4	by	by	IN
cord-305737-bnzd7b25	189	5	the	the	DT
cord-305737-bnzd7b25	189	6	innate	innate	JJ
cord-305737-bnzd7b25	189	7	immune	immune	JJ
cord-305737-bnzd7b25	189	8	receptor	receptor	NN
cord-305737-bnzd7b25	189	9	RIG-	rig-	NN
cord-305737-bnzd7b25	190	1	I	-PRON-	PRP
cord-305737-bnzd7b25	191	1	The	the	DT
cord-305737-bnzd7b25	191	2	structural	structural	JJ
cord-305737-bnzd7b25	191	3	basis	basis	NN
cord-305737-bnzd7b25	191	4	of	of	IN
cord-305737-bnzd7b25	191	5	5	5	CD
cord-305737-bnzd7b25	191	6	0	0	CD
cord-305737-bnzd7b25	191	7	triphosphate	triphosphate	NN
cord-305737-bnzd7b25	191	8	double	double	RB
cord-305737-bnzd7b25	191	9	-	-	HYPH
cord-305737-bnzd7b25	191	10	stranded	strand	VBN
cord-305737-bnzd7b25	191	11	RNA	rna	NN
cord-305737-bnzd7b25	191	12	recognition	recognition	NN
cord-305737-bnzd7b25	191	13	by	by	IN
cord-305737-bnzd7b25	191	14	RIG	rig	NN
cord-305737-bnzd7b25	191	15	-	-	:
cord-305737-bnzd7b25	191	16	I	I	NNP
cord-305737-bnzd7b25	191	17	C	c	NN
cord-305737-bnzd7b25	191	18	-	-	HYPH
cord-305737-bnzd7b25	191	19	terminal	terminal	NN
cord-305737-bnzd7b25	191	20	domain	domain	NN
cord-305737-bnzd7b25	191	21	Crystal	Crystal	NNP
cord-305737-bnzd7b25	191	22	structure	structure	NN
cord-305737-bnzd7b25	191	23	of	of	IN
cord-305737-bnzd7b25	191	24	RIG	rig	NN
cord-305737-bnzd7b25	191	25	-	-	:
cord-305737-bnzd7b25	191	26	I	I	NNP
cord-305737-bnzd7b25	191	27	C	c	NN
cord-305737-bnzd7b25	191	28	-	-	HYPH
cord-305737-bnzd7b25	191	29	terminal	terminal	NN
cord-305737-bnzd7b25	191	30	domain	domain	NN
cord-305737-bnzd7b25	191	31	bound	bind	VBN
cord-305737-bnzd7b25	191	32	to	to	TO
cord-305737-bnzd7b25	191	33	blunt	blunt	VB
cord-305737-bnzd7b25	191	34	-	-	HYPH
cord-305737-bnzd7b25	191	35	ended	ended	JJ
cord-305737-bnzd7b25	191	36	double	double	JJ
cord-305737-bnzd7b25	191	37	-	-	HYPH
cord-305737-bnzd7b25	191	38	strand	strand	NN
cord-305737-bnzd7b25	191	39	RNA	RNA	NNP
cord-305737-bnzd7b25	191	40	without	without	IN
cord-305737-bnzd7b25	191	41	5	5	CD
cord-305737-bnzd7b25	191	42	0	0	CD
cord-305737-bnzd7b25	191	43	triphosphate	triphosphate	NN
cord-305737-bnzd7b25	191	44	Structural	structural	JJ
cord-305737-bnzd7b25	191	45	basis	basis	NN
cord-305737-bnzd7b25	191	46	for	for	IN
cord-305737-bnzd7b25	191	47	the	the	DT
cord-305737-bnzd7b25	191	48	activation	activation	NN
cord-305737-bnzd7b25	191	49	of	of	IN
cord-305737-bnzd7b25	191	50	innate	innate	JJ
cord-305737-bnzd7b25	191	51	immune	immune	JJ
cord-305737-bnzd7b25	191	52	pattern	pattern	NN
cord-305737-bnzd7b25	191	53	-	-	HYPH
cord-305737-bnzd7b25	191	54	recognition	recognition	NN
cord-305737-bnzd7b25	191	55	receptor	receptor	NN
cord-305737-bnzd7b25	191	56	RIG	rig	NN
cord-305737-bnzd7b25	191	57	-	-	:
cord-305737-bnzd7b25	191	58	I	i	NN
cord-305737-bnzd7b25	191	59	by	by	IN
cord-305737-bnzd7b25	191	60	viral	viral	JJ
cord-305737-bnzd7b25	191	61	RNA	RNA	NNP
cord-305737-bnzd7b25	192	1	This	this	DT
cord-305737-bnzd7b25	192	2	paper	paper	NN
cord-305737-bnzd7b25	192	3	describes	describe	VBZ
cord-305737-bnzd7b25	192	4	the	the	DT
cord-305737-bnzd7b25	192	5	structure	structure	NN
cord-305737-bnzd7b25	192	6	of	of	IN
cord-305737-bnzd7b25	192	7	full	full	JJ
cord-305737-bnzd7b25	192	8	-	-	HYPH
cord-305737-bnzd7b25	192	9	length	length	NN
cord-305737-bnzd7b25	192	10	RIG	rig	NN
cord-305737-bnzd7b25	192	11	-	-	:
cord-305737-bnzd7b25	192	12	I	-PRON-	PRP
cord-305737-bnzd7b25	192	13	and	and	CC
cord-305737-bnzd7b25	192	14	reveals	reveal	VBZ
cord-305737-bnzd7b25	192	15	an	an	DT
cord-305737-bnzd7b25	192	16	important	important	JJ
cord-305737-bnzd7b25	192	17	interaction	interaction	NN
cord-305737-bnzd7b25	192	18	between	between	IN
cord-305737-bnzd7b25	192	19	CARD2	CARD2	NNS
cord-305737-bnzd7b25	192	20	and	and	CC
cord-305737-bnzd7b25	192	21	the	the	DT
cord-305737-bnzd7b25	192	22	helicase	helicase	NN
cord-305737-bnzd7b25	192	23	domain	domain	NN
cord-305737-bnzd7b25	192	24	that	that	WDT
cord-305737-bnzd7b25	192	25	explains	explain	VBZ
cord-305737-bnzd7b25	192	26	RIG-	RIG-	NNP
cord-305737-bnzd7b25	193	1	I	-PRON-	PRP
cord-305737-bnzd7b25	193	2	autorepression	autorepression	NN
cord-305737-bnzd7b25	194	1	The	the	DT
cord-305737-bnzd7b25	194	2	RIG	rig	NN
cord-305737-bnzd7b25	194	3	-	-	:
cord-305737-bnzd7b25	194	4	I	-PRON-	PRP
cord-305737-bnzd7b25	194	5	ATPase	ATPase	NNP
cord-305737-bnzd7b25	194	6	domain	domain	NN
cord-305737-bnzd7b25	194	7	structure	structure	NN
cord-305737-bnzd7b25	194	8	reveals	reveal	VBZ
cord-305737-bnzd7b25	194	9	insights	insight	NNS
cord-305737-bnzd7b25	194	10	into	into	IN
cord-305737-bnzd7b25	194	11	ATP	ATP	NNP
cord-305737-bnzd7b25	194	12	-	-	HYPH
cord-305737-bnzd7b25	194	13	dependent	dependent	JJ
cord-305737-bnzd7b25	194	14	antiviral	antiviral	JJ
cord-305737-bnzd7b25	194	15	signalling	signal	VBG
cord-305737-bnzd7b25	194	16	Structure	structure	NN
cord-305737-bnzd7b25	194	17	and	and	CC
cord-305737-bnzd7b25	194	18	dynamics	dynamic	NNS
cord-305737-bnzd7b25	194	19	of	of	IN
cord-305737-bnzd7b25	194	20	the	the	DT
cord-305737-bnzd7b25	194	21	second	second	JJ
cord-305737-bnzd7b25	194	22	CARD	card	NN
cord-305737-bnzd7b25	194	23	of	of	IN
cord-305737-bnzd7b25	194	24	human	human	JJ
cord-305737-bnzd7b25	194	25	RIG	rig	NN
cord-305737-bnzd7b25	194	26	-	-	:
cord-305737-bnzd7b25	194	27	I	-PRON-	PRP
cord-305737-bnzd7b25	194	28	provide	provide	VBP
cord-305737-bnzd7b25	194	29	mechanistic	mechanistic	JJ
cord-305737-bnzd7b25	194	30	insights	insight	NNS
cord-305737-bnzd7b25	194	31	into	into	IN
cord-305737-bnzd7b25	194	32	regulation	regulation	NN
cord-305737-bnzd7b25	194	33	of	of	IN
cord-305737-bnzd7b25	194	34	RIG-	RIG-	NNP
cord-305737-bnzd7b25	195	1	I	-PRON-	PRP
cord-305737-bnzd7b25	195	2	activation	activation	VBP
cord-305737-bnzd7b25	195	3	Structural	structural	JJ
cord-305737-bnzd7b25	195	4	basis	basis	NN
cord-305737-bnzd7b25	195	5	of	of	IN
cord-305737-bnzd7b25	195	6	RNA	RNA	NNP
cord-305737-bnzd7b25	195	7	recognition	recognition	NN
cord-305737-bnzd7b25	195	8	and	and	CC
cord-305737-bnzd7b25	195	9	activation	activation	NN
cord-305737-bnzd7b25	195	10	by	by	IN
cord-305737-bnzd7b25	195	11	innate	innate	JJ
cord-305737-bnzd7b25	195	12	immune	immune	JJ
cord-305737-bnzd7b25	195	13	receptor	receptor	NN
cord-305737-bnzd7b25	195	14	RIG	rig	NN
cord-305737-bnzd7b25	196	1	-I	-I	NFP
cord-305737-bnzd7b25	196	2	These	these	DT
cord-305737-bnzd7b25	196	3	studies	study	NNS
cord-305737-bnzd7b25	196	4	report	report	VBP
cord-305737-bnzd7b25	196	5	the	the	DT
cord-305737-bnzd7b25	196	6	crystal	crystal	JJ
cord-305737-bnzd7b25	196	7	structure	structure	NN
cord-305737-bnzd7b25	196	8	of	of	IN
cord-305737-bnzd7b25	196	9	the	the	DT
cord-305737-bnzd7b25	196	10	RIG	rig	NN
cord-305737-bnzd7b25	196	11	-	-	:
cord-305737-bnzd7b25	196	12	I	-PRON-	PRP
cord-305737-bnzd7b25	196	13	helicase	helicase	NN
cord-305737-bnzd7b25	196	14	domain	domain	NN
cord-305737-bnzd7b25	196	15	and	and	CC
cord-305737-bnzd7b25	196	16	CTD	CTD	NNP
cord-305737-bnzd7b25	196	17	in	in	IN
cord-305737-bnzd7b25	196	18	complex	complex	NN
cord-305737-bnzd7b25	196	19	with	with	IN
cord-305737-bnzd7b25	196	20	RNA	RNA	NNP
cord-305737-bnzd7b25	196	21	and	and	CC
cord-305737-bnzd7b25	196	22	provide	provide	VB
cord-305737-bnzd7b25	196	23	insights	insight	NNS
cord-305737-bnzd7b25	196	24	into	into	IN
cord-305737-bnzd7b25	196	25	the	the	DT
cord-305737-bnzd7b25	196	26	conformation	conformation	NN
cord-305737-bnzd7b25	196	27	of	of	IN
cord-305737-bnzd7b25	196	28	the	the	DT
cord-305737-bnzd7b25	196	29	activated	activate	VBN
cord-305737-bnzd7b25	196	30	receptor	receptor	NN
cord-305737-bnzd7b25	196	31	Structural	structural	JJ
cord-305737-bnzd7b25	196	32	insights	insight	NNS
cord-305737-bnzd7b25	196	33	into	into	IN
cord-305737-bnzd7b25	196	34	RNA	RNA	NNP
cord-305737-bnzd7b25	196	35	recognition	recognition	NN
cord-305737-bnzd7b25	196	36	by	by	IN
cord-305737-bnzd7b25	196	37	RIG	rig	NN
cord-305737-bnzd7b25	197	1	-I	-i	WDT
cord-305737-bnzd7b25	197	2	See	see	VB
cord-305737-bnzd7b25	197	3	annotation	annotation	NN
cord-305737-bnzd7b25	197	4	to	to	IN
cord-305737-bnzd7b25	197	5	Ref	ref	NN
cord-305737-bnzd7b25	197	6	Visualizing	visualize	VBG
cord-305737-bnzd7b25	197	7	the	the	DT
cord-305737-bnzd7b25	197	8	determinants	determinant	NNS
cord-305737-bnzd7b25	197	9	of	of	IN
cord-305737-bnzd7b25	197	10	viral	viral	JJ
cord-305737-bnzd7b25	197	11	RNA	RNA	NNP
cord-305737-bnzd7b25	197	12	recognition	recognition	NN
cord-305737-bnzd7b25	197	13	by	by	IN
cord-305737-bnzd7b25	197	14	innate	innate	JJ
cord-305737-bnzd7b25	197	15	immune	immune	JJ
cord-305737-bnzd7b25	197	16	sensor	sensor	NN
cord-305737-bnzd7b25	197	17	RIG	rig	NN
cord-305737-bnzd7b25	198	1	-I	-i	WDT
cord-305737-bnzd7b25	198	2	See	see	VB
cord-305737-bnzd7b25	198	3	annotation	annotation	NN
cord-305737-bnzd7b25	198	4	to	to	IN
cord-305737-bnzd7b25	198	5	Ref	ref	NN
cord-305737-bnzd7b25	198	6	Structural	structural	JJ
cord-305737-bnzd7b25	198	7	basis	basis	NN
cord-305737-bnzd7b25	198	8	for	for	IN
cord-305737-bnzd7b25	198	9	dsRNA	dsrna	NN
cord-305737-bnzd7b25	198	10	recognition	recognition	NN
cord-305737-bnzd7b25	198	11	,	,	,
cord-305737-bnzd7b25	198	12	filament	filament	NN
cord-305737-bnzd7b25	198	13	formation	formation	NN
cord-305737-bnzd7b25	198	14	,	,	,
cord-305737-bnzd7b25	198	15	and	and	CC
cord-305737-bnzd7b25	198	16	antiviral	antiviral	JJ
cord-305737-bnzd7b25	198	17	signal	signal	NN
cord-305737-bnzd7b25	198	18	activation	activation	NN
cord-305737-bnzd7b25	198	19	by	by	IN
cord-305737-bnzd7b25	198	20	MDA5	MDA5	NNP
cord-305737-bnzd7b25	199	1	This	this	DT
cord-305737-bnzd7b25	199	2	work	work	NN
cord-305737-bnzd7b25	199	3	on	on	IN
cord-305737-bnzd7b25	199	4	the	the	DT
cord-305737-bnzd7b25	199	5	structure	structure	NN
cord-305737-bnzd7b25	199	6	of	of	IN
cord-305737-bnzd7b25	199	7	the	the	DT
cord-305737-bnzd7b25	199	8	MDA5	mda5	JJ
cord-305737-bnzd7b25	199	9	helicase	helicase	NN
cord-305737-bnzd7b25	199	10	domain	domain	NN
cord-305737-bnzd7b25	199	11	and	and	CC
cord-305737-bnzd7b25	199	12	CTD	CTD	NNP
cord-305737-bnzd7b25	199	13	highlights	highlight	VBZ
cord-305737-bnzd7b25	199	14	similarities	similarity	NNS
cord-305737-bnzd7b25	199	15	and	and	CC
cord-305737-bnzd7b25	199	16	differences	difference	NNS
cord-305737-bnzd7b25	199	17	between	between	IN
cord-305737-bnzd7b25	199	18	RIG	rig	NN
cord-305737-bnzd7b25	199	19	-	-	:
cord-305737-bnzd7b25	199	20	I	I	NNP
cord-305737-bnzd7b25	199	21	and	and	CC
cord-305737-bnzd7b25	199	22	MDA5	MDA5	NNP
cord-305737-bnzd7b25	199	23	that	that	WDT
cord-305737-bnzd7b25	199	24	may	may	MD
cord-305737-bnzd7b25	199	25	explain	explain	VB
cord-305737-bnzd7b25	199	26	why	why	WRB
cord-305737-bnzd7b25	199	27	these	these	DT
cord-305737-bnzd7b25	199	28	RLRs	rlr	NNS
cord-305737-bnzd7b25	199	29	recognize	recognize	VBP
cord-305737-bnzd7b25	199	30	different	different	JJ
cord-305737-bnzd7b25	199	31	types	type	NNS
cord-305737-bnzd7b25	199	32	of	of	IN
cord-305737-bnzd7b25	199	33	RNA	RNA	NNP
cord-305737-bnzd7b25	199	34	Structural	structural	JJ
cord-305737-bnzd7b25	199	35	basis	basis	NN
cord-305737-bnzd7b25	199	36	of	of	IN
cord-305737-bnzd7b25	199	37	double	double	RB
cord-305737-bnzd7b25	199	38	-	-	HYPH
cord-305737-bnzd7b25	199	39	stranded	strand	VBN
cord-305737-bnzd7b25	199	40	RNA	RNA	NNP
cord-305737-bnzd7b25	199	41	recognition	recognition	NN
cord-305737-bnzd7b25	199	42	by	by	IN
cord-305737-bnzd7b25	199	43	the	the	DT
cord-305737-bnzd7b25	199	44	RIG	rig	NN
cord-305737-bnzd7b25	200	1	-I	-i	WDT
cord-305737-bnzd7b25	200	2	like	like	IN
cord-305737-bnzd7b25	200	3	receptor	receptor	NN
cord-305737-bnzd7b25	200	4	MDA5	MDA5	NNP
cord-305737-bnzd7b25	200	5	Solution	Solution	NNP
cord-305737-bnzd7b25	200	6	structures	structure	NNS
cord-305737-bnzd7b25	200	7	of	of	IN
cord-305737-bnzd7b25	200	8	cytosolic	cytosolic	JJ
cord-305737-bnzd7b25	200	9	RNA	RNA	NNP
cord-305737-bnzd7b25	200	10	sensor	sensor	NN
cord-305737-bnzd7b25	200	11	MDA5	MDA5	NNP
cord-305737-bnzd7b25	200	12	and	and	CC
cord-305737-bnzd7b25	200	13	LGP2	LGP2	NNP
cord-305737-bnzd7b25	200	14	Cterminal	Cterminal	NNP
cord-305737-bnzd7b25	200	15	domains	domain	NNS
cord-305737-bnzd7b25	200	16	:	:	:
cord-305737-bnzd7b25	200	17	identification	identification	NN
cord-305737-bnzd7b25	200	18	of	of	IN
cord-305737-bnzd7b25	200	19	the	the	DT
cord-305737-bnzd7b25	200	20	RNA	RNA	NNP
cord-305737-bnzd7b25	200	21	recognition	recognition	NN
cord-305737-bnzd7b25	200	22	loop	loop	NN
cord-305737-bnzd7b25	200	23	in	in	IN
cord-305737-bnzd7b25	200	24	RIG	rig	NN
cord-305737-bnzd7b25	201	1	-I	-I	JJS
cord-305737-bnzd7b25	201	2	-	-	HYPH
cord-305737-bnzd7b25	201	3	like	like	JJ
cord-305737-bnzd7b25	201	4	receptors	receptor	NNS
cord-305737-bnzd7b25	202	1	Exposing	expose	VBG
cord-305737-bnzd7b25	202	2	viruses	virus	NNS
cord-305737-bnzd7b25	202	3	:	:	:
cord-305737-bnzd7b25	202	4	RNA	rna	NN
cord-305737-bnzd7b25	202	5	patterns	pattern	NNS
cord-305737-bnzd7b25	202	6	sensed	sense	VBN
cord-305737-bnzd7b25	202	7	by	by	IN
cord-305737-bnzd7b25	202	8	RIG	rig	NN
cord-305737-bnzd7b25	202	9	-	-	:
cord-305737-bnzd7b25	202	10	Ilike	Ilike	NNP
cord-305737-bnzd7b25	202	11	receptors	receptor	NNS
cord-305737-bnzd7b25	202	12	Differential	differential	JJ
cord-305737-bnzd7b25	202	13	roles	role	NNS
cord-305737-bnzd7b25	202	14	of	of	IN
cord-305737-bnzd7b25	202	15	MDA5	MDA5	NNP
cord-305737-bnzd7b25	202	16	and	and	CC
cord-305737-bnzd7b25	202	17	RIG	rig	NN
cord-305737-bnzd7b25	203	1	-I	-i	DT
cord-305737-bnzd7b25	203	2	helicases	helicase	NNS
cord-305737-bnzd7b25	203	3	in	in	IN
cord-305737-bnzd7b25	203	4	the	the	DT
cord-305737-bnzd7b25	203	5	recognition	recognition	NN
cord-305737-bnzd7b25	203	6	of	of	IN
cord-305737-bnzd7b25	203	7	RNA	RNA	NNP
cord-305737-bnzd7b25	203	8	viruses	virus	NNS
cord-305737-bnzd7b25	203	9	TRIM25	TRIM25	NNP
cord-305737-bnzd7b25	203	10	RING	ring	NN
cord-305737-bnzd7b25	203	11	-	-	HYPH
cord-305737-bnzd7b25	203	12	finger	finger	NN
cord-305737-bnzd7b25	203	13	E3	e3	NN
cord-305737-bnzd7b25	203	14	ubiquitin	ubiquitin	NN
cord-305737-bnzd7b25	203	15	ligase	ligase	NN
cord-305737-bnzd7b25	203	16	is	be	VBZ
cord-305737-bnzd7b25	203	17	essential	essential	JJ
cord-305737-bnzd7b25	203	18	for	for	IN
cord-305737-bnzd7b25	203	19	RIG	rig	NN
cord-305737-bnzd7b25	203	20	-	-	HYPH
cord-305737-bnzd7b25	203	21	I	i	NN
cord-305737-bnzd7b25	203	22	-	-	HYPH
cord-305737-bnzd7b25	203	23	mediated	mediate	VBN
cord-305737-bnzd7b25	203	24	antiviral	antiviral	JJ
cord-305737-bnzd7b25	203	25	activity	activity	NN
cord-305737-bnzd7b25	203	26	Ubiquitin	Ubiquitin	NNP
cord-305737-bnzd7b25	203	27	-	-	HYPH
cord-305737-bnzd7b25	203	28	induced	induce	VBN
cord-305737-bnzd7b25	203	29	oligomerization	oligomerization	NN
cord-305737-bnzd7b25	203	30	of	of	IN
cord-305737-bnzd7b25	203	31	the	the	DT
cord-305737-bnzd7b25	203	32	RNA	RNA	NNP
cord-305737-bnzd7b25	203	33	sensors	sensor	NNS
cord-305737-bnzd7b25	203	34	RIG	rig	NN
cord-305737-bnzd7b25	203	35	-	-	:
cord-305737-bnzd7b25	203	36	I	I	NNP
cord-305737-bnzd7b25	203	37	and	and	CC
cord-305737-bnzd7b25	203	38	MDA5	MDA5	NNP
cord-305737-bnzd7b25	203	39	activates	activate	VBZ
cord-305737-bnzd7b25	203	40	antiviral	antiviral	JJ
cord-305737-bnzd7b25	203	41	innate	innate	JJ
cord-305737-bnzd7b25	203	42	immune	immune	JJ
cord-305737-bnzd7b25	203	43	response	response	NN
cord-305737-bnzd7b25	203	44	This	this	DT
cord-305737-bnzd7b25	203	45	paper	paper	NN
cord-305737-bnzd7b25	203	46	shows	show	VBZ
cord-305737-bnzd7b25	203	47	that	that	WDT
cord-305737-bnzd7b25	203	48	activated	activate	VBN
cord-305737-bnzd7b25	203	49	RIG	rig	NN
cord-305737-bnzd7b25	203	50	-	-	:
cord-305737-bnzd7b25	203	51	I	-PRON-	PRP
cord-305737-bnzd7b25	203	52	forms	form	VBZ
cord-305737-bnzd7b25	203	53	tetramers	tetramer	NNS
cord-305737-bnzd7b25	203	54	and	and	CC
cord-305737-bnzd7b25	203	55	that	that	IN
cord-305737-bnzd7b25	203	56	noncovalent	noncovalent	NN
cord-305737-bnzd7b25	203	57	binding	binding	NN
cord-305737-bnzd7b25	203	58	of	of	IN
cord-305737-bnzd7b25	203	59	RIG	rig	NN
cord-305737-bnzd7b25	203	60	-	-	:
cord-305737-bnzd7b25	203	61	I	I	NNP
cord-305737-bnzd7b25	203	62	and	and	CC
cord-305737-bnzd7b25	203	63	MDA5	MDA5	NNP
cord-305737-bnzd7b25	203	64	to	to	IN
cord-305737-bnzd7b25	203	65	K63-linked	K63-linked	NNP
cord-305737-bnzd7b25	203	66	ubiquitin	ubiquitin	NN
cord-305737-bnzd7b25	203	67	chains	chain	NNS
cord-305737-bnzd7b25	203	68	is	be	VBZ
cord-305737-bnzd7b25	203	69	required	require	VBN
cord-305737-bnzd7b25	203	70	for	for	IN
cord-305737-bnzd7b25	203	71	signaling	signal	VBG
cord-305737-bnzd7b25	203	72	to	to	IN
cord-305737-bnzd7b25	203	73	MAVS	MAVS	NNP
cord-305737-bnzd7b25	203	74	MAVS	MAVS	NNP
cord-305737-bnzd7b25	203	75	forms	form	VBZ
cord-305737-bnzd7b25	203	76	functional	functional	JJ
cord-305737-bnzd7b25	203	77	prion	prion	NN
cord-305737-bnzd7b25	203	78	-	-	HYPH
cord-305737-bnzd7b25	203	79	like	like	JJ
cord-305737-bnzd7b25	203	80	aggregates	aggregate	NNS
cord-305737-bnzd7b25	203	81	to	to	TO
cord-305737-bnzd7b25	203	82	activate	activate	VB
cord-305737-bnzd7b25	203	83	and	and	CC
cord-305737-bnzd7b25	203	84	propagate	propagate	VB
cord-305737-bnzd7b25	203	85	antiviral	antiviral	JJ
cord-305737-bnzd7b25	203	86	innate	innate	JJ
cord-305737-bnzd7b25	203	87	immune	immune	JJ
cord-305737-bnzd7b25	203	88	response	response	NN
cord-305737-bnzd7b25	203	89	This	this	DT
cord-305737-bnzd7b25	203	90	study	study	NN
cord-305737-bnzd7b25	203	91	shows	show	VBZ
cord-305737-bnzd7b25	203	92	that	that	IN
cord-305737-bnzd7b25	203	93	MAVS	MAVS	NNP
cord-305737-bnzd7b25	203	94	forms	form	VBZ
cord-305737-bnzd7b25	203	95	prion	prion	NN
cord-305737-bnzd7b25	203	96	-	-	HYPH
cord-305737-bnzd7b25	203	97	like	like	JJ
cord-305737-bnzd7b25	203	98	aggregates	aggregate	NNS
cord-305737-bnzd7b25	203	99	that	that	WDT
cord-305737-bnzd7b25	203	100	activate	activate	VBP
cord-305737-bnzd7b25	203	101	TBK1	TBK1	NNP
cord-305737-bnzd7b25	203	102	and	and	CC
cord-305737-bnzd7b25	203	103	thus	thus	RB
cord-305737-bnzd7b25	203	104	reveals	reveal	VBZ
cord-305737-bnzd7b25	203	105	an	an	DT
cord-305737-bnzd7b25	203	106	unexpected	unexpected	JJ
cord-305737-bnzd7b25	203	107	mechanism	mechanism	NN
cord-305737-bnzd7b25	203	108	of	of	IN
cord-305737-bnzd7b25	203	109	signal	signal	NN
cord-305737-bnzd7b25	203	110	amplification	amplification	NN
cord-305737-bnzd7b25	203	111	in	in	IN
cord-305737-bnzd7b25	203	112	the	the	DT
cord-305737-bnzd7b25	203	113	RIG	rig	NN
cord-305737-bnzd7b25	203	114	-	-	:
cord-305737-bnzd7b25	203	115	I	-PRON-	PRP
cord-305737-bnzd7b25	203	116	pathway	pathway	NN
cord-305737-bnzd7b25	203	117	Defining	define	VBG
cord-305737-bnzd7b25	203	118	the	the	DT
cord-305737-bnzd7b25	203	119	subcellular	subcellular	JJ
cord-305737-bnzd7b25	203	120	sites	site	NNS
cord-305737-bnzd7b25	203	121	of	of	IN
cord-305737-bnzd7b25	203	122	innate	innate	JJ
cord-305737-bnzd7b25	203	123	immune	immune	JJ
cord-305737-bnzd7b25	203	124	signal	signal	NN
cord-305737-bnzd7b25	203	125	transduction	transduction	NN
cord-305737-bnzd7b25	203	126	Peroxisomes	peroxisome	NNS
cord-305737-bnzd7b25	203	127	are	be	VBP
cord-305737-bnzd7b25	203	128	signaling	signal	VBG
cord-305737-bnzd7b25	203	129	platforms	platform	NNS
cord-305737-bnzd7b25	203	130	for	for	IN
cord-305737-bnzd7b25	203	131	antiviral	antiviral	JJ
cord-305737-bnzd7b25	203	132	innate	innate	JJ
cord-305737-bnzd7b25	203	133	immunity	immunity	NN
cord-305737-bnzd7b25	203	134	Mitochondrialassociated	mitochondrialassociate	VBN
cord-305737-bnzd7b25	203	135	endoplasmic	endoplasmic	NN
cord-305737-bnzd7b25	203	136	reticulum	reticulum	NN
cord-305737-bnzd7b25	203	137	membranes	membrane	NNS
cord-305737-bnzd7b25	203	138	(	(	-LRB-
cord-305737-bnzd7b25	203	139	MAM	MAM	NNP
cord-305737-bnzd7b25	203	140	)	)	-RRB-
cord-305737-bnzd7b25	203	141	form	form	NN
cord-305737-bnzd7b25	203	142	innate	innate	JJ
cord-305737-bnzd7b25	203	143	immune	immune	JJ
cord-305737-bnzd7b25	203	144	synapses	synapsis	NNS
cord-305737-bnzd7b25	203	145	and	and	CC
cord-305737-bnzd7b25	203	146	are	be	VBP
cord-305737-bnzd7b25	203	147	targeted	target	VBN
cord-305737-bnzd7b25	203	148	by	by	IN
cord-305737-bnzd7b25	203	149	hepatitis	hepatitis	NN
cord-305737-bnzd7b25	203	150	C	C	NNP
cord-305737-bnzd7b25	203	151	virus	virus	NN
cord-305737-bnzd7b25	203	152	0	0	CD
cord-305737-bnzd7b25	203	153	-O	-O	:
cord-305737-bnzd7b25	203	154	methylation	methylation	NN
cord-305737-bnzd7b25	203	155	of	of	IN
cord-305737-bnzd7b25	203	156	the	the	DT
cord-305737-bnzd7b25	203	157	viral	viral	JJ
cord-305737-bnzd7b25	203	158	mRNA	mRNA	NNP
cord-305737-bnzd7b25	203	159	cap	cap	NN
cord-305737-bnzd7b25	203	160	evades	evade	VBZ
cord-305737-bnzd7b25	203	161	host	host	NN
cord-305737-bnzd7b25	203	162	restriction	restriction	NN
cord-305737-bnzd7b25	203	163	by	by	IN
cord-305737-bnzd7b25	203	164	IFIT	IFIT	NNP
cord-305737-bnzd7b25	203	165	family	family	NN
cord-305737-bnzd7b25	203	166	members	member	NNS
cord-305737-bnzd7b25	204	1	Interferoninduced	Interferoninduced	NNP
cord-305737-bnzd7b25	204	2	Ifit2	Ifit2	NNP
cord-305737-bnzd7b25	205	1	/ISG54	/ISG54	NFP
cord-305737-bnzd7b25	205	2	protects	protect	VBZ
cord-305737-bnzd7b25	205	3	mice	mouse	NNS
cord-305737-bnzd7b25	205	4	from	from	IN
cord-305737-bnzd7b25	205	5	lethal	lethal	JJ
cord-305737-bnzd7b25	205	6	VSV	VSV	NNP
cord-305737-bnzd7b25	205	7	neuropathogenesis	neuropathogenesis	NNP
cord-305737-bnzd7b25	205	8	0	0	CD
cord-305737-bnzd7b25	206	1	-O	-O	:
cord-305737-bnzd7b25	206	2	methylation	methylation	NN
cord-305737-bnzd7b25	206	3	of	of	IN
cord-305737-bnzd7b25	206	4	the	the	DT
cord-305737-bnzd7b25	206	5	viral	viral	JJ
cord-305737-bnzd7b25	206	6	mRNA	mRNA	NNP
cord-305737-bnzd7b25	206	7	cap	cap	NN
cord-305737-bnzd7b25	206	8	by	by	IN
cord-305737-bnzd7b25	206	9	West	West	NNP
cord-305737-bnzd7b25	206	10	Nile	Nile	NNP
cord-305737-bnzd7b25	206	11	virus	virus	NN
cord-305737-bnzd7b25	206	12	evades	evade	VBZ
cord-305737-bnzd7b25	206	13	ifit1-dependent	ifit1-dependent	JJ
cord-305737-bnzd7b25	206	14	and	and	CC
cord-305737-bnzd7b25	206	15	-independent	-independent	JJ
cord-305737-bnzd7b25	206	16	mechanisms	mechanism	NNS
cord-305737-bnzd7b25	206	17	of	of	IN
cord-305737-bnzd7b25	206	18	host	host	NN
cord-305737-bnzd7b25	206	19	restriction	restriction	NN
cord-305737-bnzd7b25	206	20	in	in	IN
cord-305737-bnzd7b25	206	21	vivo	vivo	NN
cord-305737-bnzd7b25	207	1	Ribose	ribose	NN
cord-305737-bnzd7b25	207	2	2	2	CD
cord-305737-bnzd7b25	207	3	0	0	CD
cord-305737-bnzd7b25	207	4	-O	-o	CD
cord-305737-bnzd7b25	207	5	-	-	HYPH
cord-305737-bnzd7b25	207	6	methylation	methylation	NN
cord-305737-bnzd7b25	207	7	provides	provide	VBZ
cord-305737-bnzd7b25	207	8	a	a	DT
cord-305737-bnzd7b25	207	9	molecular	molecular	JJ
cord-305737-bnzd7b25	207	10	signature	signature	NN
cord-305737-bnzd7b25	207	11	for	for	IN
cord-305737-bnzd7b25	207	12	the	the	DT
cord-305737-bnzd7b25	207	13	distinction	distinction	NN
cord-305737-bnzd7b25	207	14	of	of	IN
cord-305737-bnzd7b25	207	15	self	self	NN
cord-305737-bnzd7b25	207	16	and	and	CC
cord-305737-bnzd7b25	207	17	non	non	JJ
cord-305737-bnzd7b25	207	18	-	-	JJ
cord-305737-bnzd7b25	207	19	self	self	JJ
cord-305737-bnzd7b25	207	20	mRNA	mrna	NN
cord-305737-bnzd7b25	207	21	dependent	dependent	JJ
cord-305737-bnzd7b25	207	22	on	on	IN
cord-305737-bnzd7b25	207	23	the	the	DT
cord-305737-bnzd7b25	207	24	RNA	RNA	NNP
cord-305737-bnzd7b25	207	25	sensor	sensor	NN
cord-305737-bnzd7b25	207	26	Mda5	Mda5	NNP
cord-305737-bnzd7b25	207	27	Using	use	VBG
cord-305737-bnzd7b25	207	28	biochemical	biochemical	JJ
cord-305737-bnzd7b25	207	29	and	and	CC
cord-305737-bnzd7b25	207	30	structural	structural	JJ
cord-305737-bnzd7b25	207	31	analysis	analysis	NN
cord-305737-bnzd7b25	207	32	,	,	,
cord-305737-bnzd7b25	207	33	this	this	DT
cord-305737-bnzd7b25	207	34	work	work	NN
cord-305737-bnzd7b25	207	35	shows	show	VBZ
cord-305737-bnzd7b25	207	36	that	that	IN
cord-305737-bnzd7b25	207	37	IFIT5	IFIT5	MD
cord-305737-bnzd7b25	207	38	also	also	RB
cord-305737-bnzd7b25	207	39	binds	bind	VBZ
cord-305737-bnzd7b25	207	40	transfer	transfer	NN
cord-305737-bnzd7b25	207	41	RNAs	rna	NNS
cord-305737-bnzd7b25	207	42	bearing	bear	VBG
cord-305737-bnzd7b25	207	43	5	5	CD
cord-305737-bnzd7b25	207	44	0	0	CD
cord-305737-bnzd7b25	208	1	-monophosphates	-monophosphates	NNP
cord-305737-bnzd7b25	208	2	Crystal	Crystal	NNP
cord-305737-bnzd7b25	208	3	structure	structure	NN
cord-305737-bnzd7b25	208	4	of	of	IN
cord-305737-bnzd7b25	208	5	ISG54	ISG54	NNP
cord-305737-bnzd7b25	208	6	reveals	reveal	VBZ
cord-305737-bnzd7b25	208	7	a	a	DT
cord-305737-bnzd7b25	208	8	novel	novel	JJ
cord-305737-bnzd7b25	208	9	RNA	RNA	NNP
cord-305737-bnzd7b25	208	10	binding	binding	NN
cord-305737-bnzd7b25	208	11	structure	structure	NN
cord-305737-bnzd7b25	208	12	and	and	CC
cord-305737-bnzd7b25	208	13	potential	potential	JJ
cord-305737-bnzd7b25	208	14	functional	functional	JJ
cord-305737-bnzd7b25	208	15	mechanisms	mechanism	NNS
cord-305737-bnzd7b25	209	1	Fields	Fields	NNP
cord-305737-bnzd7b25	209	2	Virology	Virology	NNP
cord-305737-bnzd7b25	209	3	Processing	Processing	NNP
cord-305737-bnzd7b25	209	4	of	of	IN
cord-305737-bnzd7b25	209	5	genome	genome	NN
cord-305737-bnzd7b25	209	6	5	5	CD
cord-305737-bnzd7b25	209	7	0	0	CD
cord-305737-bnzd7b25	209	8	termini	terminus	NNS
cord-305737-bnzd7b25	209	9	as	as	IN
cord-305737-bnzd7b25	209	10	a	a	DT
cord-305737-bnzd7b25	209	11	strategy	strategy	NN
cord-305737-bnzd7b25	209	12	of	of	IN
cord-305737-bnzd7b25	209	13	negative	negative	JJ
cord-305737-bnzd7b25	209	14	-	-	HYPH
cord-305737-bnzd7b25	209	15	strand	strand	NN
cord-305737-bnzd7b25	209	16	RNA	RNA	NNP
cord-305737-bnzd7b25	209	17	viruses	virus	NNS
cord-305737-bnzd7b25	209	18	to	to	TO
cord-305737-bnzd7b25	209	19	avoid	avoid	VB
cord-305737-bnzd7b25	209	20	RIG	rig	NN
cord-305737-bnzd7b25	209	21	-	-	.
cord-305737-bnzd7b25	209	22	Idependent	Idependent	NNP
cord-305737-bnzd7b25	209	23	interferon	interferon	NN
cord-305737-bnzd7b25	209	24	induction	induction	NN
cord-305737-bnzd7b25	209	25	Viral	viral	JJ
cord-305737-bnzd7b25	209	26	tricks	trick	NNS
cord-305737-bnzd7b25	209	27	to	to	IN
cord-305737-bnzd7b25	209	28	grid	grid	NN
cord-305737-bnzd7b25	209	29	-	-	:
cord-305737-bnzd7b25	209	30	lock	lock	VB
cord-305737-bnzd7b25	209	31	the	the	DT
cord-305737-bnzd7b25	209	32	type	type	NN
cord-305737-bnzd7b25	210	1	I	-PRON-	PRP
cord-305737-bnzd7b25	210	2	interferon	interferon	VBD
cord-305737-bnzd7b25	210	3	system	system	NN
cord-305737-bnzd7b25	211	1	ISG56	ISG56	NNP
cord-305737-bnzd7b25	212	1	/IFIT1	/IFIT1	NNP
cord-305737-bnzd7b25	212	2	is	be	VBZ
cord-305737-bnzd7b25	212	3	primarily	primarily	RB
cord-305737-bnzd7b25	212	4	responsible	responsible	JJ
cord-305737-bnzd7b25	212	5	for	for	IN
cord-305737-bnzd7b25	212	6	interferoninduced	interferoninduced	JJ
cord-305737-bnzd7b25	212	7	changes	change	NNS
cord-305737-bnzd7b25	212	8	to	to	IN
cord-305737-bnzd7b25	212	9	patterns	pattern	NNS
cord-305737-bnzd7b25	212	10	of	of	IN
cord-305737-bnzd7b25	212	11	parainfluenza	parainfluenza	NNP
cord-305737-bnzd7b25	212	12	virus	virus	NNP
cord-305737-bnzd7b25	212	13	type	type	NNP
cord-305737-bnzd7b25	212	14	5	5	CD
cord-305737-bnzd7b25	212	15	transcription	transcription	NN
cord-305737-bnzd7b25	212	16	and	and	CC
cord-305737-bnzd7b25	212	17	protein	protein	NN
cord-305737-bnzd7b25	212	18	synthesis	synthesis	NN
cord-305737-bnzd7b25	213	1	We	-PRON-	PRP
cord-305737-bnzd7b25	213	2	thank	thank	VBP
cord-305737-bnzd7b25	213	3	Andreas	Andreas	NNP
cord-305737-bnzd7b25	213	4	Pichlmair	Pichlmair	NNP
cord-305737-bnzd7b25	213	5	,	,	,
cord-305737-bnzd7b25	213	6	Delphine	Delphine	NNP
cord-305737-bnzd7b25	213	7	Goubau	Goubau	NNP
cord-305737-bnzd7b25	213	8	and	and	CC
cord-305737-bnzd7b25	213	9	Safia	Safia	NNP
cord-305737-bnzd7b25	213	10	Deddouche	Deddouche	NNP
cord-305737-bnzd7b25	213	11	for	for	IN
cord-305737-bnzd7b25	213	12	their	-PRON-	PRP$
cord-305737-bnzd7b25	213	13	helpful	helpful	JJ
cord-305737-bnzd7b25	213	14	comments	comment	NNS
cord-305737-bnzd7b25	213	15	,	,	,
cord-305737-bnzd7b25	213	16	and	and	CC
cord-305737-bnzd7b25	213	17	Martin	Martin	NNP
cord-305737-bnzd7b25	213	18	Jinek	Jinek	NNP
cord-305737-bnzd7b25	213	19	for	for	IN
cord-305737-bnzd7b25	213	20	his	-PRON-	PRP$
cord-305737-bnzd7b25	213	21	help	help	NN
cord-305737-bnzd7b25	213	22	in	in	IN
cord-305737-bnzd7b25	213	23	preparing	prepare	VBG
cord-305737-bnzd7b25	213	24	Figure	figure	NN
cord-305737-bnzd7b25	213	25	3	3	CD
cord-305737-bnzd7b25	213	26	.	.	.
cord-305737-bnzd7b25	214	1	We	-PRON-	PRP
cord-305737-bnzd7b25	214	2	apologize	apologize	VBP
cord-305737-bnzd7b25	214	3	to	to	IN
cord-305737-bnzd7b25	214	4	our	-PRON-	PRP$
cord-305737-bnzd7b25	214	5	colleagues	colleague	NNS
cord-305737-bnzd7b25	214	6	whose	whose	WP$
cord-305737-bnzd7b25	214	7	work	work	NN
cord-305737-bnzd7b25	214	8	could	could	MD
cord-305737-bnzd7b25	214	9	not	not	RB
cord-305737-bnzd7b25	214	10	be	be	VB
cord-305737-bnzd7b25	214	11	cited	cite	VBN
cord-305737-bnzd7b25	214	12	due	due	IN
cord-305737-bnzd7b25	214	13	to	to	IN
cord-305737-bnzd7b25	214	14	space	space	NN
cord-305737-bnzd7b25	214	15	limitations	limitation	NNS
cord-305737-bnzd7b25	214	16	.	.	.
cord-305737-bnzd7b25	215	1	CRS	CRS	NNP
cord-305737-bnzd7b25	215	2	is	be	VBZ
cord-305737-bnzd7b25	215	3	funded	fund	VBN
cord-305737-bnzd7b25	215	4	by	by	IN
cord-305737-bnzd7b25	215	5	Cancer	Cancer	NNP
cord-305737-bnzd7b25	215	6	Research	Research	NNP
cord-305737-bnzd7b25	215	7	UK	UK	NNP
cord-305737-bnzd7b25	215	8	,	,	,
cord-305737-bnzd7b25	215	9	ERC	ERC	NNP
cord-305737-bnzd7b25	215	10	and	and	CC
cord-305737-bnzd7b25	215	11	Foundation	Foundation	NNP
cord-305737-bnzd7b25	215	12	Bettencourt	Bettencourt	NNP
cord-305737-bnzd7b25	215	13	-	-	HYPH
cord-305737-bnzd7b25	215	14	Schueller	Schueller	NNP
cord-305737-bnzd7b25	215	15	.	.	.
cord-305737-bnzd7b25	216	1	JR	JR	NNP
cord-305737-bnzd7b25	216	2	is	be	VBZ
cord-305737-bnzd7b25	216	3	funded	fund	VBN
cord-305737-bnzd7b25	216	4	by	by	IN
cord-305737-bnzd7b25	216	5	the	the	DT
cord-305737-bnzd7b25	216	6	UK	UK	NNP
cord-305737-bnzd7b25	216	7	Medical	Medical	NNP
cord-305737-bnzd7b25	216	8	Research	Research	NNP
cord-305737-bnzd7b25	216	9	Council	Council	NNP
cord-305737-bnzd7b25	216	10	.	.	.