id	sid	tid	token	lemma	pos
cord-321607-3r736dnk	1	1	key	key	NN
cord-321607-3r736dnk	1	2	:	:	:
cord-321607-3r736dnk	2	1	cord-321607	cord-321607	NNP
cord-321607-3r736dnk	2	2	-	-	HYPH
cord-321607-3r736dnk	2	3	3r736dnk	3r736dnk	CD
cord-321607-3r736dnk	2	4	authors	author	NNS
cord-321607-3r736dnk	2	5	:	:	:
cord-321607-3r736dnk	2	6	Ezelle	Ezelle	NNP
cord-321607-3r736dnk	2	7	,	,	,
cord-321607-3r736dnk	2	8	Heather	Heather	NNP
cord-321607-3r736dnk	2	9	J.	J.	NNP
cord-321607-3r736dnk	2	10	;	;	:
cord-321607-3r736dnk	2	11	Malathi	Malathi	NNP
cord-321607-3r736dnk	2	12	,	,	,
cord-321607-3r736dnk	2	13	Krishnamurthy	Krishnamurthy	NNP
cord-321607-3r736dnk	2	14	;	;	:
cord-321607-3r736dnk	2	15	Hassel	Hassel	NNP
cord-321607-3r736dnk	2	16	,	,	,
cord-321607-3r736dnk	2	17	Bret	Bret	NNP
cord-321607-3r736dnk	2	18	A.	a.	NN
cord-321607-3r736dnk	2	19	title	title	NN
cord-321607-3r736dnk	2	20	:	:	:
cord-321607-3r736dnk	2	21	The	the	DT
cord-321607-3r736dnk	2	22	Roles	Roles	NNPS
cord-321607-3r736dnk	2	23	of	of	IN
cord-321607-3r736dnk	2	24	RNase	RNase	NNP
cord-321607-3r736dnk	2	25	-	-	HYPH
cord-321607-3r736dnk	2	26	L	L	NNP
cord-321607-3r736dnk	2	27	in	in	IN
cord-321607-3r736dnk	2	28	Antimicrobial	Antimicrobial	NNP
cord-321607-3r736dnk	2	29	Immunity	Immunity	NNP
cord-321607-3r736dnk	2	30	and	and	CC
cord-321607-3r736dnk	2	31	the	the	DT
cord-321607-3r736dnk	2	32	Cytoskeleton	Cytoskeleton	NNP
cord-321607-3r736dnk	2	33	-	-	HYPH
cord-321607-3r736dnk	2	34	Associated	Associated	NNP
cord-321607-3r736dnk	2	35	Innate	Innate	NNP
cord-321607-3r736dnk	2	36	Response	Response	NNP
cord-321607-3r736dnk	2	37	date	date	NN
cord-321607-3r736dnk	2	38	:	:	:
cord-321607-3r736dnk	2	39	2016	2016	CD
cord-321607-3r736dnk	2	40	-	-	HYPH
cord-321607-3r736dnk	2	41	01	01	CD
cord-321607-3r736dnk	2	42	-	-	HYPH
cord-321607-3r736dnk	2	43	08	08	CD
cord-321607-3r736dnk	2	44	journal	journal	NN
cord-321607-3r736dnk	2	45	:	:	:
cord-321607-3r736dnk	2	46	Int	Int	NNP
cord-321607-3r736dnk	2	47	J	J	NNP
cord-321607-3r736dnk	2	48	Mol	Mol	NNP
cord-321607-3r736dnk	2	49	Sci	Sci	NNP
cord-321607-3r736dnk	2	50	DOI	DOI	NNP
cord-321607-3r736dnk	2	51	:	:	:
cord-321607-3r736dnk	3	1	10.3390	10.3390	CD
cord-321607-3r736dnk	3	2	/	/	SYM
cord-321607-3r736dnk	3	3	ijms17010074	ijms17010074	NNP
cord-321607-3r736dnk	3	4	sha	sha	NNP
cord-321607-3r736dnk	3	5	:	:	:
cord-321607-3r736dnk	3	6	3f21f365d6a8983fd6cf0406c66d2785d0c3a138	3f21f365d6a8983fd6cf0406c66d2785d0c3a138	CD
cord-321607-3r736dnk	3	7	doc_id	doc_id	NNP
cord-321607-3r736dnk	3	8	:	:	:
cord-321607-3r736dnk	3	9	321607	321607	CD
cord-321607-3r736dnk	3	10	cord_uid	cord_uid	NN
cord-321607-3r736dnk	3	11	:	:	:
cord-321607-3r736dnk	3	12	3r736dnk	3r736dnk	CD
cord-321607-3r736dnk	4	1	The	the	DT
cord-321607-3r736dnk	4	2	interferon	interferon	NN
cord-321607-3r736dnk	5	1	(	(	-LRB-
cord-321607-3r736dnk	5	2	IFN)-regulated	ifn)-regulate	VBN
cord-321607-3r736dnk	5	3	endoribonuclease	endoribonuclease	NNP
cord-321607-3r736dnk	5	4	RNase	RNase	NNP
cord-321607-3r736dnk	5	5	-	-	HYPH
cord-321607-3r736dnk	5	6	L	L	NNP
cord-321607-3r736dnk	5	7	is	be	VBZ
cord-321607-3r736dnk	5	8	involved	involve	VBN
cord-321607-3r736dnk	5	9	in	in	IN
cord-321607-3r736dnk	5	10	multiple	multiple	JJ
cord-321607-3r736dnk	5	11	aspects	aspect	NNS
cord-321607-3r736dnk	5	12	of	of	IN
cord-321607-3r736dnk	5	13	the	the	DT
cord-321607-3r736dnk	5	14	antimicrobial	antimicrobial	JJ
cord-321607-3r736dnk	5	15	innate	innate	JJ
cord-321607-3r736dnk	5	16	immune	immune	JJ
cord-321607-3r736dnk	5	17	response	response	NN
cord-321607-3r736dnk	5	18	.	.	.
cord-321607-3r736dnk	6	1	It	-PRON-	PRP
cord-321607-3r736dnk	6	2	is	be	VBZ
cord-321607-3r736dnk	6	3	the	the	DT
cord-321607-3r736dnk	6	4	terminal	terminal	JJ
cord-321607-3r736dnk	6	5	component	component	NN
cord-321607-3r736dnk	6	6	of	of	IN
cord-321607-3r736dnk	6	7	an	an	DT
cord-321607-3r736dnk	6	8	RNA	RNA	NNP
cord-321607-3r736dnk	6	9	cleavage	cleavage	NN
cord-321607-3r736dnk	6	10	pathway	pathway	NN
cord-321607-3r736dnk	6	11	in	in	IN
cord-321607-3r736dnk	6	12	which	which	WDT
cord-321607-3r736dnk	6	13	dsRNA	dsrna	NN
cord-321607-3r736dnk	6	14	induces	induce	VBZ
cord-321607-3r736dnk	6	15	the	the	DT
cord-321607-3r736dnk	6	16	production	production	NN
cord-321607-3r736dnk	6	17	of	of	IN
cord-321607-3r736dnk	6	18	RNase	RNase	NNP
cord-321607-3r736dnk	6	19	-	-	HYPH
cord-321607-3r736dnk	6	20	L	l	NN
cord-321607-3r736dnk	6	21	-	-	HYPH
cord-321607-3r736dnk	6	22	activating	activate	VBG
cord-321607-3r736dnk	6	23	2	2	CD
cord-321607-3r736dnk	6	24	-	-	HYPH
cord-321607-3r736dnk	6	25	5A	5a	NN
cord-321607-3r736dnk	6	26	by	by	IN
cord-321607-3r736dnk	6	27	the	the	DT
cord-321607-3r736dnk	6	28	2′-5′-oligoadenylate	2′-5′-oligoadenylate	CD
cord-321607-3r736dnk	6	29	synthetase	synthetase	NN
cord-321607-3r736dnk	6	30	.	.	.
cord-321607-3r736dnk	7	1	The	the	DT
cord-321607-3r736dnk	7	2	active	active	JJ
cord-321607-3r736dnk	7	3	nuclease	nuclease	NN
cord-321607-3r736dnk	7	4	then	then	RB
cord-321607-3r736dnk	7	5	cleaves	cleave	VBZ
cord-321607-3r736dnk	7	6	ssRNAs	ssRNAs	NNP
cord-321607-3r736dnk	7	7	,	,	,
cord-321607-3r736dnk	7	8	both	both	DT
cord-321607-3r736dnk	7	9	cellular	cellular	JJ
cord-321607-3r736dnk	7	10	and	and	CC
cord-321607-3r736dnk	7	11	viral	viral	JJ
cord-321607-3r736dnk	7	12	,	,	,
cord-321607-3r736dnk	7	13	leading	lead	VBG
cord-321607-3r736dnk	7	14	to	to	IN
cord-321607-3r736dnk	7	15	downregulation	downregulation	NN
cord-321607-3r736dnk	7	16	of	of	IN
cord-321607-3r736dnk	7	17	their	-PRON-	PRP$
cord-321607-3r736dnk	7	18	expression	expression	NN
cord-321607-3r736dnk	7	19	and	and	CC
cord-321607-3r736dnk	7	20	the	the	DT
cord-321607-3r736dnk	7	21	generation	generation	NN
cord-321607-3r736dnk	7	22	of	of	IN
cord-321607-3r736dnk	7	23	small	small	JJ
cord-321607-3r736dnk	7	24	RNAs	rna	NNS
cord-321607-3r736dnk	7	25	capable	capable	JJ
cord-321607-3r736dnk	7	26	of	of	IN
cord-321607-3r736dnk	7	27	activating	activate	VBG
cord-321607-3r736dnk	7	28	retinoic	retinoic	JJ
cord-321607-3r736dnk	7	29	acid	acid	NN
cord-321607-3r736dnk	7	30	-	-	HYPH
cord-321607-3r736dnk	7	31	inducible	inducible	JJ
cord-321607-3r736dnk	7	32	gene	gene	NN
cord-321607-3r736dnk	7	33	-	-	:
cord-321607-3r736dnk	7	34	I	I	NNP
cord-321607-3r736dnk	7	35	(	(	-LRB-
cord-321607-3r736dnk	7	36	RIG	RIG	NNP
cord-321607-3r736dnk	7	37	-	-	HYPH
cord-321607-3r736dnk	7	38	I)-like	I)-like	NNP
cord-321607-3r736dnk	7	39	receptors	receptor	NNS
cord-321607-3r736dnk	7	40	or	or	CC
cord-321607-3r736dnk	7	41	the	the	DT
cord-321607-3r736dnk	7	42	nucleotide	nucleotide	RB
cord-321607-3r736dnk	7	43	-	-	HYPH
cord-321607-3r736dnk	7	44	binding	bind	VBG
cord-321607-3r736dnk	7	45	oligomerization	oligomerization	NN
cord-321607-3r736dnk	7	46	domain	domain	NN
cord-321607-3r736dnk	7	47	-	-	:
cord-321607-3r736dnk	7	48	like	like	JJ
cord-321607-3r736dnk	7	49	receptor	receptor	NN
cord-321607-3r736dnk	7	50	3	3	CD
cord-321607-3r736dnk	7	51	(	(	-LRB-
cord-321607-3r736dnk	7	52	NLRP3	NLRP3	NNP
cord-321607-3r736dnk	7	53	)	)	-RRB-
cord-321607-3r736dnk	7	54	inflammasome	inflammasome	NNP
cord-321607-3r736dnk	7	55	.	.	.
cord-321607-3r736dnk	8	1	This	this	DT
cord-321607-3r736dnk	8	2	leads	lead	VBZ
cord-321607-3r736dnk	8	3	to	to	IN
cord-321607-3r736dnk	8	4	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	8	5	expression	expression	NN
cord-321607-3r736dnk	8	6	and	and	CC
cord-321607-3r736dnk	8	7	IL-1β	il-1β	NN
cord-321607-3r736dnk	8	8	activation	activation	NN
cord-321607-3r736dnk	8	9	respectively	respectively	RB
cord-321607-3r736dnk	8	10	,	,	,
cord-321607-3r736dnk	8	11	in	in	IN
cord-321607-3r736dnk	8	12	addition	addition	NN
cord-321607-3r736dnk	8	13	to	to	IN
cord-321607-3r736dnk	8	14	broader	broad	JJR
cord-321607-3r736dnk	8	15	effects	effect	NNS
cord-321607-3r736dnk	8	16	on	on	IN
cord-321607-3r736dnk	8	17	immune	immune	JJ
cord-321607-3r736dnk	8	18	cell	cell	NN
cord-321607-3r736dnk	8	19	function	function	NN
cord-321607-3r736dnk	8	20	.	.	.
cord-321607-3r736dnk	9	1	RNase	RNase	NNP
cord-321607-3r736dnk	9	2	-	-	HYPH
cord-321607-3r736dnk	9	3	L	L	NNP
cord-321607-3r736dnk	9	4	is	be	VBZ
cord-321607-3r736dnk	9	5	also	also	RB
cord-321607-3r736dnk	9	6	one	one	CD
cord-321607-3r736dnk	9	7	of	of	IN
cord-321607-3r736dnk	9	8	a	a	DT
cord-321607-3r736dnk	9	9	growing	grow	VBG
cord-321607-3r736dnk	9	10	number	number	NN
cord-321607-3r736dnk	9	11	of	of	IN
cord-321607-3r736dnk	9	12	innate	innate	JJ
cord-321607-3r736dnk	9	13	immune	immune	JJ
cord-321607-3r736dnk	9	14	components	component	NNS
cord-321607-3r736dnk	9	15	that	that	WDT
cord-321607-3r736dnk	9	16	interact	interact	VBP
cord-321607-3r736dnk	9	17	with	with	IN
cord-321607-3r736dnk	9	18	the	the	DT
cord-321607-3r736dnk	9	19	cell	cell	NN
cord-321607-3r736dnk	9	20	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	9	21	.	.	.
cord-321607-3r736dnk	10	1	It	-PRON-	PRP
cord-321607-3r736dnk	10	2	can	can	MD
cord-321607-3r736dnk	10	3	bind	bind	VB
cord-321607-3r736dnk	10	4	to	to	IN
cord-321607-3r736dnk	10	5	several	several	JJ
cord-321607-3r736dnk	10	6	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	10	7	proteins	protein	NNS
cord-321607-3r736dnk	10	8	,	,	,
cord-321607-3r736dnk	10	9	including	include	VBG
cord-321607-3r736dnk	10	10	filamin	filamin	NNP
cord-321607-3r736dnk	10	11	A	A	NNP
cord-321607-3r736dnk	10	12	,	,	,
cord-321607-3r736dnk	10	13	an	an	DT
cord-321607-3r736dnk	10	14	actin	actin	NN
cord-321607-3r736dnk	10	15	-	-	HYPH
cord-321607-3r736dnk	10	16	binding	bind	VBG
cord-321607-3r736dnk	10	17	protein	protein	NN
cord-321607-3r736dnk	10	18	that	that	WDT
cord-321607-3r736dnk	10	19	collaborates	collaborate	VBZ
cord-321607-3r736dnk	10	20	with	with	IN
cord-321607-3r736dnk	10	21	RNase	RNase	NNP
cord-321607-3r736dnk	10	22	-	-	HYPH
cord-321607-3r736dnk	10	23	L	L	NNP
cord-321607-3r736dnk	10	24	to	to	TO
cord-321607-3r736dnk	10	25	maintain	maintain	VB
cord-321607-3r736dnk	10	26	the	the	DT
cord-321607-3r736dnk	10	27	cellular	cellular	JJ
cord-321607-3r736dnk	10	28	barrier	barrier	NN
cord-321607-3r736dnk	10	29	to	to	IN
cord-321607-3r736dnk	10	30	viral	viral	JJ
cord-321607-3r736dnk	10	31	entry	entry	NN
cord-321607-3r736dnk	10	32	.	.	.
cord-321607-3r736dnk	11	1	This	this	DT
cord-321607-3r736dnk	11	2	antiviral	antiviral	JJ
cord-321607-3r736dnk	11	3	activity	activity	NN
cord-321607-3r736dnk	11	4	is	be	VBZ
cord-321607-3r736dnk	11	5	independent	independent	JJ
cord-321607-3r736dnk	11	6	of	of	IN
cord-321607-3r736dnk	11	7	catalytic	catalytic	JJ
cord-321607-3r736dnk	11	8	function	function	NN
cord-321607-3r736dnk	11	9	,	,	,
cord-321607-3r736dnk	11	10	a	a	DT
cord-321607-3r736dnk	11	11	unique	unique	JJ
cord-321607-3r736dnk	11	12	mechanism	mechanism	NN
cord-321607-3r736dnk	11	13	for	for	IN
cord-321607-3r736dnk	11	14	RNase	RNase	NNP
cord-321607-3r736dnk	11	15	-	-	HYPH
cord-321607-3r736dnk	11	16	L.	L.	NNP
cord-321607-3r736dnk	12	1	We	-PRON-	PRP
cord-321607-3r736dnk	12	2	also	also	RB
cord-321607-3r736dnk	12	3	describe	describe	VBP
cord-321607-3r736dnk	12	4	here	here	RB
cord-321607-3r736dnk	12	5	the	the	DT
cord-321607-3r736dnk	12	6	interaction	interaction	NN
cord-321607-3r736dnk	12	7	of	of	IN
cord-321607-3r736dnk	12	8	RNase	RNase	NNP
cord-321607-3r736dnk	12	9	-	-	HYPH
cord-321607-3r736dnk	12	10	L	l	NN
cord-321607-3r736dnk	12	11	with	with	IN
cord-321607-3r736dnk	12	12	the	the	DT
cord-321607-3r736dnk	12	13	E3	e3	NN
cord-321607-3r736dnk	12	14	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	12	15	ligase	ligase	NN
cord-321607-3r736dnk	12	16	and	and	CC
cord-321607-3r736dnk	12	17	scaffolding	scaffolding	NN
cord-321607-3r736dnk	12	18	protein	protein	NN
cord-321607-3r736dnk	12	19	,	,	,
cord-321607-3r736dnk	12	20	ligand	ligand	NN
cord-321607-3r736dnk	12	21	of	of	IN
cord-321607-3r736dnk	12	22	nump	nump	NNP
cord-321607-3r736dnk	12	23	protein	protein	NNP
cord-321607-3r736dnk	12	24	X	X	NNP
cord-321607-3r736dnk	12	25	(	(	-LRB-
cord-321607-3r736dnk	12	26	LNX	LNX	NNP
cord-321607-3r736dnk	12	27	)	)	-RRB-
cord-321607-3r736dnk	12	28	,	,	,
cord-321607-3r736dnk	12	29	a	a	DT
cord-321607-3r736dnk	12	30	regulator	regulator	NN
cord-321607-3r736dnk	12	31	of	of	IN
cord-321607-3r736dnk	12	32	tight	tight	JJ
cord-321607-3r736dnk	12	33	junction	junction	NN
cord-321607-3r736dnk	12	34	proteins	protein	NNS
cord-321607-3r736dnk	12	35	.	.	.
cord-321607-3r736dnk	13	1	In	in	IN
cord-321607-3r736dnk	13	2	order	order	NN
cord-321607-3r736dnk	13	3	to	to	TO
cord-321607-3r736dnk	13	4	better	better	RB
cord-321607-3r736dnk	13	5	understand	understand	VB
cord-321607-3r736dnk	13	6	the	the	DT
cord-321607-3r736dnk	13	7	significance	significance	NN
cord-321607-3r736dnk	13	8	and	and	CC
cord-321607-3r736dnk	13	9	context	context	NN
cord-321607-3r736dnk	13	10	of	of	IN
cord-321607-3r736dnk	13	11	these	these	DT
cord-321607-3r736dnk	13	12	novel	novel	NN
cord-321607-3r736dnk	13	13	binding	bind	VBG
cord-321607-3r736dnk	13	14	partners	partner	NNS
cord-321607-3r736dnk	13	15	in	in	IN
cord-321607-3r736dnk	13	16	the	the	DT
cord-321607-3r736dnk	13	17	antimicrobial	antimicrobial	JJ
cord-321607-3r736dnk	13	18	response	response	NN
cord-321607-3r736dnk	13	19	,	,	,
cord-321607-3r736dnk	13	20	other	other	JJ
cord-321607-3r736dnk	13	21	innate	innate	JJ
cord-321607-3r736dnk	13	22	immune	immune	JJ
cord-321607-3r736dnk	13	23	protein	protein	NN
cord-321607-3r736dnk	13	24	interactions	interaction	NNS
cord-321607-3r736dnk	13	25	with	with	IN
cord-321607-3r736dnk	13	26	the	the	DT
cord-321607-3r736dnk	13	27	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	13	28	are	be	VBP
cord-321607-3r736dnk	13	29	also	also	RB
cord-321607-3r736dnk	13	30	discussed	discuss	VBN
cord-321607-3r736dnk	13	31	.	.	.
cord-321607-3r736dnk	14	1	RNase	RNase	NNP
cord-321607-3r736dnk	14	2	-	-	HYPH
cord-321607-3r736dnk	14	3	L	L	NNP
cord-321607-3r736dnk	14	4	is	be	VBZ
cord-321607-3r736dnk	14	5	an	an	DT
cord-321607-3r736dnk	14	6	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	14	7	that	that	WDT
cord-321607-3r736dnk	14	8	cleaves	cleave	VBZ
cord-321607-3r736dnk	14	9	single	single	RB
cord-321607-3r736dnk	14	10	-	-	HYPH
cord-321607-3r736dnk	14	11	stranded	strand	VBN
cord-321607-3r736dnk	14	12	RNA	RNA	NNP
cord-321607-3r736dnk	14	13	as	as	IN
cord-321607-3r736dnk	14	14	the	the	DT
cord-321607-3r736dnk	14	15	effector	effector	JJ
cord-321607-3r736dnk	14	16	portion	portion	NN
cord-321607-3r736dnk	14	17	of	of	IN
cord-321607-3r736dnk	14	18	a	a	DT
cord-321607-3r736dnk	14	19	two	two	CD
cord-321607-3r736dnk	14	20	-	-	HYPH
cord-321607-3r736dnk	14	21	component	component	NN
cord-321607-3r736dnk	14	22	system	system	NN
cord-321607-3r736dnk	14	23	regulated	regulate	VBN
cord-321607-3r736dnk	14	24	by	by	IN
cord-321607-3r736dnk	14	25	the	the	DT
cord-321607-3r736dnk	14	26	antiviral	antiviral	JJ
cord-321607-3r736dnk	14	27	type	type	NN
cord-321607-3r736dnk	14	28	I	-PRON-	PRP
cord-321607-3r736dnk	14	29	and	and	CC
cord-321607-3r736dnk	14	30	III	iii	CD
cord-321607-3r736dnk	14	31	interferons	interferon	NNS
cord-321607-3r736dnk	14	32	(	(	-LRB-
cord-321607-3r736dnk	14	33	IFN	IFN	NNP
cord-321607-3r736dnk	14	34	-	-	HYPH
cord-321607-3r736dnk	14	35	α	α	NNP
cord-321607-3r736dnk	14	36	/	/	SYM
cord-321607-3r736dnk	14	37	β	β	NN
cord-321607-3r736dnk	14	38	and	and	CC
cord-321607-3r736dnk	14	39	IFN	IFN	NNP
cord-321607-3r736dnk	14	40	-	-	HYPH
cord-321607-3r736dnk	14	41	λ	λ	NNP
cord-321607-3r736dnk	14	42	,	,	,
cord-321607-3r736dnk	14	43	respectively	respectively	RB
cord-321607-3r736dnk	14	44	)	)	-RRB-
cord-321607-3r736dnk	14	45	[	[	-LRB-
cord-321607-3r736dnk	14	46	1	1	CD
cord-321607-3r736dnk	14	47	,	,	,
cord-321607-3r736dnk	14	48	2	2	CD
cord-321607-3r736dnk	14	49	]	]	-RRB-
cord-321607-3r736dnk	14	50	.	.	.
cord-321607-3r736dnk	15	1	IFN	IFN	NNP
cord-321607-3r736dnk	15	2	signaling	signal	VBG
cord-321607-3r736dnk	15	3	leads	lead	VBZ
cord-321607-3r736dnk	15	4	to	to	IN
cord-321607-3r736dnk	15	5	the	the	DT
cord-321607-3r736dnk	15	6	induction	induction	NN
cord-321607-3r736dnk	15	7	of	of	IN
cord-321607-3r736dnk	15	8	oligoadenylate	oligoadenylate	NNP
cord-321607-3r736dnk	15	9	synthetases	synthetases	NNPS
cord-321607-3r736dnk	15	10	(	(	-LRB-
cord-321607-3r736dnk	15	11	OAS	OAS	NNP
cord-321607-3r736dnk	15	12	)	)	-RRB-
cord-321607-3r736dnk	15	13	which	which	WDT
cord-321607-3r736dnk	15	14	,	,	,
cord-321607-3r736dnk	15	15	following	follow	VBG
cord-321607-3r736dnk	15	16	activation	activation	NN
cord-321607-3r736dnk	15	17	by	by	IN
cord-321607-3r736dnk	15	18	double	double	JJ
cord-321607-3r736dnk	15	19	stranded	strand	VBN
cord-321607-3r736dnk	15	20	RNA	RNA	NNP
cord-321607-3r736dnk	15	21	(	(	-LRB-
cord-321607-3r736dnk	15	22	dsRNA	dsrna	NN
cord-321607-3r736dnk	15	23	)	)	-RRB-
cord-321607-3r736dnk	15	24	,	,	,
cord-321607-3r736dnk	15	25	generate	generate	VB
cord-321607-3r736dnk	16	1	2	2	CD
cord-321607-3r736dnk	16	2	1	1	CD
cord-321607-3r736dnk	16	3	-5	-5	CD
cord-321607-3r736dnk	16	4	1	1	CD
cord-321607-3r736dnk	16	5	-linked	-linked	WDT
cord-321607-3r736dnk	16	6	oligoadenylates	oligoadenylate	NNS
cord-321607-3r736dnk	16	7	(	(	-LRB-
cord-321607-3r736dnk	16	8	2	2	CD
cord-321607-3r736dnk	16	9	-	-	HYPH
cord-321607-3r736dnk	16	10	5A	5a	CD
cord-321607-3r736dnk	16	11	)	)	-RRB-
cord-321607-3r736dnk	17	1	[	[	-LRB-
cord-321607-3r736dnk	17	2	3	3	CD
cord-321607-3r736dnk	17	3	,	,	,
cord-321607-3r736dnk	17	4	4	4	CD
cord-321607-3r736dnk	17	5	]	]	-RRB-
cord-321607-3r736dnk	17	6	.	.	.
cord-321607-3r736dnk	18	1	2	2	LS
cord-321607-3r736dnk	18	2	-	-	SYM
cord-321607-3r736dnk	18	3	5A	5a	NN
cord-321607-3r736dnk	18	4	then	then	RB
cord-321607-3r736dnk	18	5	binds	bind	VBZ
cord-321607-3r736dnk	18	6	to	to	IN
cord-321607-3r736dnk	18	7	RNase	RNase	NNP
cord-321607-3r736dnk	18	8	-	-	HYPH
cord-321607-3r736dnk	18	9	L	L	NNP
cord-321607-3r736dnk	18	10	,	,	,
cord-321607-3r736dnk	18	11	leading	lead	VBG
cord-321607-3r736dnk	18	12	to	to	IN
cord-321607-3r736dnk	18	13	its	-PRON-	PRP$
cord-321607-3r736dnk	18	14	dimerization	dimerization	NN
cord-321607-3r736dnk	18	15	and	and	CC
cord-321607-3r736dnk	18	16	enabling	enable	VBG
cord-321607-3r736dnk	18	17	its	-PRON-	PRP$
cord-321607-3r736dnk	18	18	nuclease	nuclease	NN
cord-321607-3r736dnk	18	19	activity	activity	NN
cord-321607-3r736dnk	18	20	[	[	-LRB-
cord-321607-3r736dnk	18	21	4	4	CD
cord-321607-3r736dnk	18	22	]	]	-RRB-
cord-321607-3r736dnk	18	23	.	.	.
cord-321607-3r736dnk	19	1	Although	although	IN
cord-321607-3r736dnk	19	2	originally	originally	RB
cord-321607-3r736dnk	19	3	characterized	characterize	VBN
cord-321607-3r736dnk	19	4	as	as	IN
cord-321607-3r736dnk	19	5	an	an	DT
cord-321607-3r736dnk	19	6	antiviral	antiviral	JJ
cord-321607-3r736dnk	19	7	agent	agent	NN
cord-321607-3r736dnk	19	8	,	,	,
cord-321607-3r736dnk	19	9	almost	almost	RB
cord-321607-3r736dnk	19	10	40	40	CD
cord-321607-3r736dnk	19	11	years	year	NNS
cord-321607-3r736dnk	19	12	of	of	IN
cord-321607-3r736dnk	19	13	research	research	NN
cord-321607-3r736dnk	19	14	has	have	VBZ
cord-321607-3r736dnk	19	15	unveiled	unveil	VBN
cord-321607-3r736dnk	19	16	many	many	JJ
cord-321607-3r736dnk	19	17	additional	additional	JJ
cord-321607-3r736dnk	19	18	and	and	CC
cord-321607-3r736dnk	19	19	diverse	diverse	JJ
cord-321607-3r736dnk	19	20	functions	function	NNS
cord-321607-3r736dnk	19	21	for	for	IN
cord-321607-3r736dnk	19	22	this	this	DT
cord-321607-3r736dnk	19	23	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	19	24	,	,	,
cord-321607-3r736dnk	19	25	as	as	RB
cord-321607-3r736dnk	19	26	well	well	RB
cord-321607-3r736dnk	19	27	as	as	IN
cord-321607-3r736dnk	19	28	novel	novel	NN
cord-321607-3r736dnk	19	29	mechanisms	mechanism	NNS
cord-321607-3r736dnk	19	30	for	for	IN
cord-321607-3r736dnk	19	31	both	both	PDT
cord-321607-3r736dnk	19	32	these	these	DT
cord-321607-3r736dnk	19	33	new	new	JJ
cord-321607-3r736dnk	19	34	and	and	CC
cord-321607-3r736dnk	19	35	its	-PRON-	PRP$
cord-321607-3r736dnk	19	36	more	more	RBR
cord-321607-3r736dnk	19	37	established	established	JJ
cord-321607-3r736dnk	19	38	antimicrobial	antimicrobial	JJ
cord-321607-3r736dnk	19	39	activities	activity	NNS
cord-321607-3r736dnk	19	40	.	.	.
cord-321607-3r736dnk	20	1	In	in	IN
cord-321607-3r736dnk	20	2	the	the	DT
cord-321607-3r736dnk	20	3	late	late	JJ
cord-321607-3r736dnk	20	4	1970	1970	CD
cord-321607-3r736dnk	20	5	1	1	CD
cord-321607-3r736dnk	20	6	s	s	NNPS
cord-321607-3r736dnk	20	7	,	,	,
cord-321607-3r736dnk	20	8	the	the	DT
cord-321607-3r736dnk	20	9	2	2	CD
cord-321607-3r736dnk	20	10	-	-	HYPH
cord-321607-3r736dnk	20	11	5A	5a	NN
cord-321607-3r736dnk	20	12	-	-	HYPH
cord-321607-3r736dnk	20	13	dependence	dependence	NN
cord-321607-3r736dnk	20	14	and	and	CC
cord-321607-3r736dnk	20	15	endonucleolytic	endonucleolytic	JJ
cord-321607-3r736dnk	20	16	properties	property	NNS
cord-321607-3r736dnk	20	17	of	of	IN
cord-321607-3r736dnk	20	18	RNase	RNase	NNP
cord-321607-3r736dnk	20	19	-	-	HYPH
cord-321607-3r736dnk	20	20	L	L	NNP
cord-321607-3r736dnk	20	21	were	be	VBD
cord-321607-3r736dnk	20	22	being	be	VBG
cord-321607-3r736dnk	20	23	investigated	investigate	VBN
cord-321607-3r736dnk	20	24	by	by	IN
cord-321607-3r736dnk	20	25	multiple	multiple	JJ
cord-321607-3r736dnk	20	26	laboratories	laboratory	NNS
cord-321607-3r736dnk	20	27	around	around	IN
cord-321607-3r736dnk	20	28	the	the	DT
cord-321607-3r736dnk	20	29	world	world	NN
cord-321607-3r736dnk	20	30	[	[	-LRB-
cord-321607-3r736dnk	20	31	5	5	CD
cord-321607-3r736dnk	20	32	]	]	-RRB-
cord-321607-3r736dnk	20	33	[	[	-LRB-
cord-321607-3r736dnk	20	34	6	6	CD
cord-321607-3r736dnk	20	35	]	]	-RRB-
cord-321607-3r736dnk	20	36	[	[	-LRB-
cord-321607-3r736dnk	20	37	7	7	CD
cord-321607-3r736dnk	20	38	]	]	-RRB-
cord-321607-3r736dnk	20	39	[	[	-LRB-
cord-321607-3r736dnk	20	40	8	8	CD
cord-321607-3r736dnk	20	41	]	]	-RRB-
cord-321607-3r736dnk	20	42	[	[	-LRB-
cord-321607-3r736dnk	20	43	9	9	CD
cord-321607-3r736dnk	20	44	]	]	-RRB-
cord-321607-3r736dnk	20	45	.	.	.
cord-321607-3r736dnk	21	1	The	the	DT
cord-321607-3r736dnk	21	2	cloning	cloning	NN
cord-321607-3r736dnk	21	3	of	of	IN
cord-321607-3r736dnk	21	4	RNase	RNase	NNP
cord-321607-3r736dnk	21	5	-	-	HYPH
cord-321607-3r736dnk	21	6	L	l	NN
cord-321607-3r736dnk	21	7	by	by	IN
cord-321607-3r736dnk	21	8	the	the	DT
cord-321607-3r736dnk	21	9	Silverman	Silverman	NNP
cord-321607-3r736dnk	21	10	lab	lab	NN
cord-321607-3r736dnk	21	11	in	in	IN
cord-321607-3r736dnk	21	12	1993	1993	CD
cord-321607-3r736dnk	21	13	then	then	RB
cord-321607-3r736dnk	21	14	opened	open	VBD
cord-321607-3r736dnk	21	15	the	the	DT
cord-321607-3r736dnk	21	16	door	door	NN
cord-321607-3r736dnk	21	17	for	for	IN
cord-321607-3r736dnk	21	18	genetic	genetic	JJ
cord-321607-3r736dnk	21	19	manipulation	manipulation	NN
cord-321607-3r736dnk	21	20	and	and	CC
cord-321607-3r736dnk	21	21	more	more	RBR
cord-321607-3r736dnk	21	22	definitive	definitive	JJ
cord-321607-3r736dnk	21	23	characterization	characterization	NN
cord-321607-3r736dnk	21	24	of	of	IN
cord-321607-3r736dnk	21	25	is	be	VBZ
cord-321607-3r736dnk	21	26	normally	normally	RB
cord-321607-3r736dnk	21	27	repressed	repress	VBN
cord-321607-3r736dnk	21	28	due	due	IN
cord-321607-3r736dnk	21	29	to	to	IN
cord-321607-3r736dnk	21	30	interactions	interaction	NNS
cord-321607-3r736dnk	21	31	between	between	IN
cord-321607-3r736dnk	21	32	the	the	DT
cord-321607-3r736dnk	21	33	ankyrin	ankyrin	NNP
cord-321607-3r736dnk	21	34	repeat	repeat	NN
cord-321607-3r736dnk	21	35	domain	domain	NN
cord-321607-3r736dnk	21	36	and	and	CC
cord-321607-3r736dnk	21	37	the	the	DT
cord-321607-3r736dnk	21	38	enzymatic	enzymatic	JJ
cord-321607-3r736dnk	21	39	domain	domain	NN
cord-321607-3r736dnk	21	40	,	,	,
cord-321607-3r736dnk	21	41	however	however	RB
cord-321607-3r736dnk	21	42	upon	upon	IN
cord-321607-3r736dnk	21	43	binding	bind	VBG
cord-321607-3r736dnk	21	44	to	to	IN
cord-321607-3r736dnk	21	45	2	2	CD
cord-321607-3r736dnk	21	46	-	-	HYPH
cord-321607-3r736dnk	21	47	5A	5a	CD
cord-321607-3r736dnk	21	48	,	,	,
cord-321607-3r736dnk	21	49	a	a	DT
cord-321607-3r736dnk	21	50	conformational	conformational	JJ
cord-321607-3r736dnk	21	51	change	change	NN
cord-321607-3r736dnk	21	52	in	in	IN
cord-321607-3r736dnk	21	53	the	the	DT
cord-321607-3r736dnk	21	54	KEN	KEN	NNP
cord-321607-3r736dnk	21	55	domain	domain	NN
cord-321607-3r736dnk	21	56	occurs	occur	VBZ
cord-321607-3r736dnk	21	57	to	to	TO
cord-321607-3r736dnk	21	58	expose	expose	VB
cord-321607-3r736dnk	21	59	the	the	DT
cord-321607-3r736dnk	21	60	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	21	61	and	and	CC
cord-321607-3r736dnk	21	62	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	21	63	domains	domain	NNS
cord-321607-3r736dnk	21	64	[	[	-LRB-
cord-321607-3r736dnk	21	65	43	43	CD
cord-321607-3r736dnk	21	66	]	]	-RRB-
cord-321607-3r736dnk	21	67	.	.	.
cord-321607-3r736dnk	22	1	Recent	recent	JJ
cord-321607-3r736dnk	22	2	crystal	crystal	NN
cord-321607-3r736dnk	22	3	structure	structure	NN
cord-321607-3r736dnk	22	4	data	datum	NNS
cord-321607-3r736dnk	22	5	indicate	indicate	VBP
cord-321607-3r736dnk	22	6	that	that	IN
cord-321607-3r736dnk	22	7	2	2	CD
cord-321607-3r736dnk	22	8	-	-	HYPH
cord-321607-3r736dnk	22	9	5A	5a	NN
cord-321607-3r736dnk	22	10	binds	bind	VBZ
cord-321607-3r736dnk	22	11	to	to	IN
cord-321607-3r736dnk	22	12	the	the	DT
cord-321607-3r736dnk	22	13	second	second	JJ
cord-321607-3r736dnk	22	14	and	and	CC
cord-321607-3r736dnk	22	15	fourth	fourth	JJ
cord-321607-3r736dnk	22	16	ankyrin	ankyrin	NN
cord-321607-3r736dnk	22	17	repeats	repeat	VBZ
cord-321607-3r736dnk	22	18	and	and	CC
cord-321607-3r736dnk	22	19	the	the	DT
cord-321607-3r736dnk	22	20	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	22	21	domain	domain	NN
cord-321607-3r736dnk	22	22	.	.	.
cord-321607-3r736dnk	23	1	These	these	DT
cord-321607-3r736dnk	23	2	interactions	interaction	NNS
cord-321607-3r736dnk	23	3	,	,	,
cord-321607-3r736dnk	23	4	in	in	IN
cord-321607-3r736dnk	23	5	conjunction	conjunction	NN
cord-321607-3r736dnk	23	6	with	with	IN
cord-321607-3r736dnk	23	7	binding	bind	VBG
cord-321607-3r736dnk	23	8	between	between	IN
cord-321607-3r736dnk	23	9	the	the	DT
cord-321607-3r736dnk	23	10	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	23	11	domains	domain	NNS
cord-321607-3r736dnk	23	12	of	of	IN
cord-321607-3r736dnk	23	13	the	the	DT
cord-321607-3r736dnk	23	14	two	two	CD
cord-321607-3r736dnk	23	15	protomers	protomer	NNS
cord-321607-3r736dnk	23	16	,	,	,
cord-321607-3r736dnk	23	17	mediate	mediate	VB
cord-321607-3r736dnk	23	18	dimerization	dimerization	NN
cord-321607-3r736dnk	23	19	and	and	CC
cord-321607-3r736dnk	23	20	enzymatic	enzymatic	JJ
cord-321607-3r736dnk	23	21	activation	activation	NN
cord-321607-3r736dnk	23	22	within	within	IN
cord-321607-3r736dnk	23	23	minutes	minute	NNS
cord-321607-3r736dnk	23	24	[	[	-LRB-
cord-321607-3r736dnk	23	25	48	48	CD
cord-321607-3r736dnk	23	26	]	]	-RRB-
cord-321607-3r736dnk	23	27	[	[	-LRB-
cord-321607-3r736dnk	23	28	49	49	CD
cord-321607-3r736dnk	23	29	]	]	-RRB-
cord-321607-3r736dnk	23	30	[	[	-LRB-
cord-321607-3r736dnk	23	31	50	50	CD
cord-321607-3r736dnk	23	32	]	]	-RRB-
cord-321607-3r736dnk	23	33	.	.	.
cord-321607-3r736dnk	24	1	The	the	DT
cord-321607-3r736dnk	24	2	crystallization	crystallization	NN
cord-321607-3r736dnk	24	3	studies	study	NNS
cord-321607-3r736dnk	24	4	have	have	VBP
cord-321607-3r736dnk	24	5	also	also	RB
cord-321607-3r736dnk	24	6	cast	cast	VBN
cord-321607-3r736dnk	24	7	a	a	DT
cord-321607-3r736dnk	24	8	new	new	JJ
cord-321607-3r736dnk	24	9	light	light	NN
cord-321607-3r736dnk	24	10	on	on	IN
cord-321607-3r736dnk	24	11	other	other	JJ
cord-321607-3r736dnk	24	12	canonical	canonical	JJ
cord-321607-3r736dnk	24	13	aspects	aspect	NNS
cord-321607-3r736dnk	24	14	of	of	IN
cord-321607-3r736dnk	24	15	RNase	RNase	NNP
cord-321607-3r736dnk	24	16	-	-	HYPH
cord-321607-3r736dnk	24	17	L	l	NN
cord-321607-3r736dnk	24	18	activation	activation	NN
cord-321607-3r736dnk	24	19	.	.	.
cord-321607-3r736dnk	25	1	Previously	previously	RB
cord-321607-3r736dnk	25	2	,	,	,
cord-321607-3r736dnk	25	3	active	active	JJ
cord-321607-3r736dnk	25	4	RNase	RNase	NNP
cord-321607-3r736dnk	25	5	-	-	HYPH
cord-321607-3r736dnk	25	6	L	L	NNP
cord-321607-3r736dnk	25	7	was	be	VBD
cord-321607-3r736dnk	25	8	generally	generally	RB
cord-321607-3r736dnk	25	9	believed	believe	VBN
cord-321607-3r736dnk	25	10	to	to	TO
cord-321607-3r736dnk	25	11	be	be	VB
cord-321607-3r736dnk	25	12	a	a	DT
cord-321607-3r736dnk	25	13	homodimer	homodimer	JJ
cord-321607-3r736dnk	25	14	bound	bind	VBN
cord-321607-3r736dnk	25	15	to	to	IN
cord-321607-3r736dnk	25	16	2	2	CD
cord-321607-3r736dnk	25	17	-	-	SYM
cord-321607-3r736dnk	25	18	5A.	5a.	CD
cord-321607-3r736dnk	26	1	In	in	IN
cord-321607-3r736dnk	26	2	vitro	vitro	FW
cord-321607-3r736dnk	26	3	activation	activation	NN
cord-321607-3r736dnk	26	4	analysis	analysis	NN
cord-321607-3r736dnk	26	5	indicates	indicate	VBZ
cord-321607-3r736dnk	26	6	that	that	IN
cord-321607-3r736dnk	26	7	RNase	RNase	NNP
cord-321607-3r736dnk	26	8	-	-	HYPH
cord-321607-3r736dnk	26	9	L	L	NNP
cord-321607-3r736dnk	26	10	can	can	MD
cord-321607-3r736dnk	26	11	in	in	IN
cord-321607-3r736dnk	26	12	fact	fact	NN
cord-321607-3r736dnk	26	13	oligomerize	oligomerize	NNP
cord-321607-3r736dnk	26	14	into	into	IN
cord-321607-3r736dnk	26	15	complexes	complex	NNS
cord-321607-3r736dnk	26	16	of	of	IN
cord-321607-3r736dnk	26	17	two	two	CD
cord-321607-3r736dnk	26	18	or	or	CC
cord-321607-3r736dnk	26	19	more	more	JJR
cord-321607-3r736dnk	26	20	monomers	monomer	NNS
cord-321607-3r736dnk	26	21	and	and	CC
cord-321607-3r736dnk	26	22	that	that	IN
cord-321607-3r736dnk	26	23	at	at	IN
cord-321607-3r736dnk	26	24	micromolar	micromolar	JJ
cord-321607-3r736dnk	26	25	concentrations	concentration	NNS
cord-321607-3r736dnk	26	26	of	of	IN
cord-321607-3r736dnk	26	27	RNase	RNase	NNP
cord-321607-3r736dnk	26	28	-	-	HYPH
cord-321607-3r736dnk	26	29	L	l	NN
cord-321607-3r736dnk	26	30	,	,	,
cord-321607-3r736dnk	26	31	2	2	CD
cord-321607-3r736dnk	26	32	-	-	HYPH
cord-321607-3r736dnk	26	33	5A	5a	NN
cord-321607-3r736dnk	26	34	is	be	VBZ
cord-321607-3r736dnk	26	35	dispensable	dispensable	JJ
cord-321607-3r736dnk	26	36	for	for	IN
cord-321607-3r736dnk	26	37	this	this	DT
cord-321607-3r736dnk	26	38	oligomerization	oligomerization	NN
cord-321607-3r736dnk	26	39	[	[	-LRB-
cord-321607-3r736dnk	26	40	49	49	CD
cord-321607-3r736dnk	26	41	]	]	-RRB-
cord-321607-3r736dnk	26	42	.	.	.
cord-321607-3r736dnk	27	1	Whether	whether	IN
cord-321607-3r736dnk	27	2	physiologic	physiologic	JJ
cord-321607-3r736dnk	27	3	concentrations	concentration	NNS
cord-321607-3r736dnk	27	4	of	of	IN
cord-321607-3r736dnk	27	5	RNase	RNase	NNP
cord-321607-3r736dnk	27	6	-	-	HYPH
cord-321607-3r736dnk	27	7	L	l	NN
cord-321607-3r736dnk	27	8	reach	reach	VB
cord-321607-3r736dnk	27	9	these	these	DT
cord-321607-3r736dnk	27	10	levels	level	NNS
cord-321607-3r736dnk	27	11	is	be	VBZ
cord-321607-3r736dnk	27	12	unknown	unknown	JJ
cord-321607-3r736dnk	27	13	.	.	.
cord-321607-3r736dnk	28	1	Once	once	RB
cord-321607-3r736dnk	28	2	active	active	JJ
cord-321607-3r736dnk	28	3	,	,	,
cord-321607-3r736dnk	28	4	RNase	RNase	NNP
cord-321607-3r736dnk	28	5	-	-	HYPH
cord-321607-3r736dnk	28	6	L	L	NNP
cord-321607-3r736dnk	28	7	cleaves	cleave	VBZ
cord-321607-3r736dnk	28	8	ssRNA	ssRNA	''
cord-321607-3r736dnk	28	9	,	,	,
cord-321607-3r736dnk	28	10	including	include	VBG
cord-321607-3r736dnk	28	11	cellular	cellular	JJ
cord-321607-3r736dnk	28	12	mRNA	mRNA	NNP
cord-321607-3r736dnk	28	13	and	and	CC
cord-321607-3r736dnk	28	14	rRNA	rrna	NN
cord-321607-3r736dnk	28	15	as	as	RB
cord-321607-3r736dnk	28	16	well	well	RB
cord-321607-3r736dnk	28	17	as	as	IN
cord-321607-3r736dnk	28	18	microbial	microbial	JJ
cord-321607-3r736dnk	28	19	RNAs	rna	NNS
cord-321607-3r736dnk	28	20	[	[	-LRB-
cord-321607-3r736dnk	28	21	51	51	CD
cord-321607-3r736dnk	28	22	,	,	,
cord-321607-3r736dnk	28	23	52	52	CD
cord-321607-3r736dnk	28	24	]	]	-RRB-
cord-321607-3r736dnk	28	25	.	.	.
cord-321607-3r736dnk	29	1	The	the	DT
cord-321607-3r736dnk	29	2	targeting	targeting	NN
cord-321607-3r736dnk	29	3	of	of	IN
cord-321607-3r736dnk	29	4	microbial	microbial	JJ
cord-321607-3r736dnk	29	5	RNAs	rna	NNS
cord-321607-3r736dnk	29	6	has	have	VBZ
cord-321607-3r736dnk	29	7	a	a	DT
cord-321607-3r736dnk	29	8	significant	significant	JJ
cord-321607-3r736dnk	29	9	impact	impact	NN
cord-321607-3r736dnk	29	10	on	on	IN
cord-321607-3r736dnk	29	11	the	the	DT
cord-321607-3r736dnk	29	12	ability	ability	NN
cord-321607-3r736dnk	29	13	of	of	IN
cord-321607-3r736dnk	29	14	the	the	DT
cord-321607-3r736dnk	29	15	virus	virus	NN
cord-321607-3r736dnk	29	16	or	or	CC
cord-321607-3r736dnk	29	17	bacterium	bacterium	NN
cord-321607-3r736dnk	29	18	to	to	TO
cord-321607-3r736dnk	29	19	replicate	replicate	VB
cord-321607-3r736dnk	29	20	,	,	,
cord-321607-3r736dnk	29	21	as	as	IN
cord-321607-3r736dnk	29	22	does	do	VBZ
cord-321607-3r736dnk	29	23	the	the	DT
cord-321607-3r736dnk	29	24	inhibition	inhibition	NN
cord-321607-3r736dnk	29	25	of	of	IN
cord-321607-3r736dnk	29	26	cellular	cellular	JJ
cord-321607-3r736dnk	29	27	translation	translation	NN
cord-321607-3r736dnk	29	28	resulting	result	VBG
cord-321607-3r736dnk	29	29	from	from	IN
cord-321607-3r736dnk	29	30	the	the	DT
cord-321607-3r736dnk	29	31	cleavage	cleavage	NN
cord-321607-3r736dnk	29	32	of	of	IN
cord-321607-3r736dnk	29	33	rRNA	rrna	NN
cord-321607-3r736dnk	29	34	and	and	CC
cord-321607-3r736dnk	29	35	ribosomal	ribosomal	JJ
cord-321607-3r736dnk	29	36	protein	protein	NN
cord-321607-3r736dnk	29	37	transcripts	transcript	NNS
cord-321607-3r736dnk	29	38	[	[	-LRB-
cord-321607-3r736dnk	29	39	6	6	CD
cord-321607-3r736dnk	29	40	,	,	,
cord-321607-3r736dnk	29	41	26	26	CD
cord-321607-3r736dnk	29	42	,	,	,
cord-321607-3r736dnk	29	43	41	41	CD
cord-321607-3r736dnk	29	44	,	,	,
cord-321607-3r736dnk	29	45	53	53	CD
cord-321607-3r736dnk	29	46	]	]	-RRB-
cord-321607-3r736dnk	29	47	.	.	.
cord-321607-3r736dnk	30	1	mRNA	mrna	NN
cord-321607-3r736dnk	30	2	targeting	targeting	NN
cord-321607-3r736dnk	30	3	can	can	MD
cord-321607-3r736dnk	30	4	facilitate	facilitate	VB
cord-321607-3r736dnk	30	5	RNase	RNase	NNP
cord-321607-3r736dnk	30	6	-	-	HYPH
cord-321607-3r736dnk	30	7	L	l	NN
cord-321607-3r736dnk	30	8	-	-	HYPH
cord-321607-3r736dnk	30	9	dependent	dependent	JJ
cord-321607-3r736dnk	30	10	regulation	regulation	NN
cord-321607-3r736dnk	30	11	of	of	IN
cord-321607-3r736dnk	30	12	gene	gene	NN
cord-321607-3r736dnk	30	13	expression	expression	NN
cord-321607-3r736dnk	30	14	through	through	IN
cord-321607-3r736dnk	30	15	direct	direct	JJ
cord-321607-3r736dnk	30	16	cleavage	cleavage	NN
cord-321607-3r736dnk	30	17	of	of	IN
cord-321607-3r736dnk	30	18	transcripts	transcript	NNS
cord-321607-3r736dnk	30	19	or	or	CC
cord-321607-3r736dnk	30	20	indirectly	indirectly	RB
cord-321607-3r736dnk	30	21	through	through	IN
cord-321607-3r736dnk	30	22	the	the	DT
cord-321607-3r736dnk	30	23	destabilization	destabilization	NN
cord-321607-3r736dnk	30	24	of	of	IN
cord-321607-3r736dnk	30	25	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	30	26	regulators	regulator	NNS
cord-321607-3r736dnk	30	27	[	[	-LRB-
cord-321607-3r736dnk	30	28	54	54	CD
cord-321607-3r736dnk	30	29	]	]	-RRB-
cord-321607-3r736dnk	30	30	.	.	.
cord-321607-3r736dnk	31	1	Historically	historically	RB
cord-321607-3r736dnk	31	2	,	,	,
cord-321607-3r736dnk	31	3	this	this	DT
cord-321607-3r736dnk	31	4	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	31	5	activity	activity	NN
cord-321607-3r736dnk	31	6	has	have	VBZ
cord-321607-3r736dnk	31	7	been	be	VBN
cord-321607-3r736dnk	31	8	considered	consider	VBN
cord-321607-3r736dnk	31	9	the	the	DT
cord-321607-3r736dnk	31	10	major	major	JJ
cord-321607-3r736dnk	31	11	mediator	mediator	NN
cord-321607-3r736dnk	31	12	of	of	IN
cord-321607-3r736dnk	31	13	the	the	DT
cord-321607-3r736dnk	31	14	biological	biological	JJ
cord-321607-3r736dnk	31	15	activities	activity	NNS
cord-321607-3r736dnk	31	16	of	of	IN
cord-321607-3r736dnk	31	17	RNase	RNase	NNP
cord-321607-3r736dnk	31	18	-	-	HYPH
cord-321607-3r736dnk	31	19	L.	L.	NNP
cord-321607-3r736dnk	31	20	Nucleolytic	Nucleolytic	NNP
cord-321607-3r736dnk	31	21	activity	activity	NN
cord-321607-3r736dnk	31	22	is	be	VBZ
cord-321607-3r736dnk	31	23	normally	normally	RB
cord-321607-3r736dnk	31	24	repressed	repress	VBN
cord-321607-3r736dnk	31	25	due	due	IN
cord-321607-3r736dnk	31	26	to	to	IN
cord-321607-3r736dnk	31	27	interactions	interaction	NNS
cord-321607-3r736dnk	31	28	between	between	IN
cord-321607-3r736dnk	31	29	the	the	DT
cord-321607-3r736dnk	31	30	ankyrin	ankyrin	NNP
cord-321607-3r736dnk	31	31	repeat	repeat	NN
cord-321607-3r736dnk	31	32	domain	domain	NN
cord-321607-3r736dnk	31	33	and	and	CC
cord-321607-3r736dnk	31	34	the	the	DT
cord-321607-3r736dnk	31	35	enzymatic	enzymatic	JJ
cord-321607-3r736dnk	31	36	domain	domain	NN
cord-321607-3r736dnk	31	37	,	,	,
cord-321607-3r736dnk	31	38	however	however	RB
cord-321607-3r736dnk	31	39	upon	upon	IN
cord-321607-3r736dnk	31	40	binding	bind	VBG
cord-321607-3r736dnk	31	41	to	to	IN
cord-321607-3r736dnk	31	42	2	2	CD
cord-321607-3r736dnk	31	43	-	-	HYPH
cord-321607-3r736dnk	31	44	5A	5a	CD
cord-321607-3r736dnk	31	45	,	,	,
cord-321607-3r736dnk	31	46	a	a	DT
cord-321607-3r736dnk	31	47	conformational	conformational	JJ
cord-321607-3r736dnk	31	48	change	change	NN
cord-321607-3r736dnk	31	49	in	in	IN
cord-321607-3r736dnk	31	50	the	the	DT
cord-321607-3r736dnk	31	51	KEN	KEN	NNP
cord-321607-3r736dnk	31	52	domain	domain	NN
cord-321607-3r736dnk	31	53	occurs	occur	VBZ
cord-321607-3r736dnk	31	54	to	to	TO
cord-321607-3r736dnk	31	55	expose	expose	VB
cord-321607-3r736dnk	31	56	the	the	DT
cord-321607-3r736dnk	31	57	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	31	58	and	and	CC
cord-321607-3r736dnk	31	59	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	31	60	domains	domain	NNS
cord-321607-3r736dnk	31	61	[	[	-LRB-
cord-321607-3r736dnk	31	62	43	43	CD
cord-321607-3r736dnk	31	63	]	]	-RRB-
cord-321607-3r736dnk	31	64	.	.	.
cord-321607-3r736dnk	32	1	Recent	recent	JJ
cord-321607-3r736dnk	32	2	crystal	crystal	NN
cord-321607-3r736dnk	32	3	structure	structure	NN
cord-321607-3r736dnk	32	4	data	datum	NNS
cord-321607-3r736dnk	32	5	indicate	indicate	VBP
cord-321607-3r736dnk	32	6	that	that	IN
cord-321607-3r736dnk	32	7	2	2	CD
cord-321607-3r736dnk	32	8	-	-	HYPH
cord-321607-3r736dnk	32	9	5A	5a	NN
cord-321607-3r736dnk	32	10	binds	bind	VBZ
cord-321607-3r736dnk	32	11	to	to	IN
cord-321607-3r736dnk	32	12	the	the	DT
cord-321607-3r736dnk	32	13	second	second	JJ
cord-321607-3r736dnk	32	14	and	and	CC
cord-321607-3r736dnk	32	15	fourth	fourth	JJ
cord-321607-3r736dnk	32	16	ankyrin	ankyrin	NN
cord-321607-3r736dnk	32	17	repeats	repeat	VBZ
cord-321607-3r736dnk	32	18	and	and	CC
cord-321607-3r736dnk	32	19	the	the	DT
cord-321607-3r736dnk	32	20	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	32	21	domain	domain	NN
cord-321607-3r736dnk	32	22	.	.	.
cord-321607-3r736dnk	33	1	These	these	DT
cord-321607-3r736dnk	33	2	interactions	interaction	NNS
cord-321607-3r736dnk	33	3	,	,	,
cord-321607-3r736dnk	33	4	in	in	IN
cord-321607-3r736dnk	33	5	conjunction	conjunction	NN
cord-321607-3r736dnk	33	6	with	with	IN
cord-321607-3r736dnk	33	7	binding	bind	VBG
cord-321607-3r736dnk	33	8	between	between	IN
cord-321607-3r736dnk	33	9	the	the	DT
cord-321607-3r736dnk	33	10	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	33	11	domains	domain	NNS
cord-321607-3r736dnk	33	12	of	of	IN
cord-321607-3r736dnk	33	13	the	the	DT
cord-321607-3r736dnk	33	14	two	two	CD
cord-321607-3r736dnk	33	15	protomers	protomer	NNS
cord-321607-3r736dnk	33	16	,	,	,
cord-321607-3r736dnk	33	17	mediate	mediate	VB
cord-321607-3r736dnk	33	18	dimerization	dimerization	NN
cord-321607-3r736dnk	33	19	and	and	CC
cord-321607-3r736dnk	33	20	enzymatic	enzymatic	JJ
cord-321607-3r736dnk	33	21	activation	activation	NN
cord-321607-3r736dnk	33	22	within	within	IN
cord-321607-3r736dnk	33	23	minutes	minute	NNS
cord-321607-3r736dnk	33	24	[	[	-LRB-
cord-321607-3r736dnk	33	25	48	48	CD
cord-321607-3r736dnk	33	26	]	]	-RRB-
cord-321607-3r736dnk	33	27	[	[	-LRB-
cord-321607-3r736dnk	33	28	49	49	CD
cord-321607-3r736dnk	33	29	]	]	-RRB-
cord-321607-3r736dnk	33	30	[	[	-LRB-
cord-321607-3r736dnk	33	31	50	50	CD
cord-321607-3r736dnk	33	32	]	]	-RRB-
cord-321607-3r736dnk	33	33	.	.	.
cord-321607-3r736dnk	34	1	The	the	DT
cord-321607-3r736dnk	34	2	crystallization	crystallization	NN
cord-321607-3r736dnk	34	3	studies	study	NNS
cord-321607-3r736dnk	34	4	have	have	VBP
cord-321607-3r736dnk	34	5	also	also	RB
cord-321607-3r736dnk	34	6	cast	cast	VBN
cord-321607-3r736dnk	34	7	a	a	DT
cord-321607-3r736dnk	34	8	new	new	JJ
cord-321607-3r736dnk	34	9	light	light	NN
cord-321607-3r736dnk	34	10	on	on	IN
cord-321607-3r736dnk	34	11	other	other	JJ
cord-321607-3r736dnk	34	12	canonical	canonical	JJ
cord-321607-3r736dnk	34	13	aspects	aspect	NNS
cord-321607-3r736dnk	34	14	of	of	IN
cord-321607-3r736dnk	34	15	RNase	RNase	NNP
cord-321607-3r736dnk	34	16	-	-	HYPH
cord-321607-3r736dnk	34	17	L	l	NN
cord-321607-3r736dnk	34	18	activation	activation	NN
cord-321607-3r736dnk	34	19	.	.	.
cord-321607-3r736dnk	35	1	Previously	previously	RB
cord-321607-3r736dnk	35	2	,	,	,
cord-321607-3r736dnk	35	3	active	active	JJ
cord-321607-3r736dnk	35	4	RNase	RNase	NNP
cord-321607-3r736dnk	35	5	-	-	HYPH
cord-321607-3r736dnk	35	6	L	L	NNP
cord-321607-3r736dnk	35	7	was	be	VBD
cord-321607-3r736dnk	35	8	generally	generally	RB
cord-321607-3r736dnk	35	9	believed	believe	VBN
cord-321607-3r736dnk	35	10	to	to	TO
cord-321607-3r736dnk	35	11	be	be	VB
cord-321607-3r736dnk	35	12	a	a	DT
cord-321607-3r736dnk	35	13	homodimer	homodimer	JJ
cord-321607-3r736dnk	35	14	bound	bind	VBN
cord-321607-3r736dnk	35	15	to	to	IN
cord-321607-3r736dnk	35	16	2	2	CD
cord-321607-3r736dnk	35	17	-	-	SYM
cord-321607-3r736dnk	35	18	5A.	5a.	CD
cord-321607-3r736dnk	36	1	In	in	IN
cord-321607-3r736dnk	36	2	vitro	vitro	FW
cord-321607-3r736dnk	36	3	activation	activation	NN
cord-321607-3r736dnk	36	4	analysis	analysis	NN
cord-321607-3r736dnk	36	5	indicates	indicate	VBZ
cord-321607-3r736dnk	36	6	that	that	IN
cord-321607-3r736dnk	36	7	RNase	RNase	NNP
cord-321607-3r736dnk	36	8	-	-	HYPH
cord-321607-3r736dnk	36	9	L	L	NNP
cord-321607-3r736dnk	36	10	can	can	MD
cord-321607-3r736dnk	36	11	in	in	IN
cord-321607-3r736dnk	36	12	fact	fact	NN
cord-321607-3r736dnk	36	13	oligomerize	oligomerize	NNP
cord-321607-3r736dnk	36	14	into	into	IN
cord-321607-3r736dnk	36	15	complexes	complex	NNS
cord-321607-3r736dnk	36	16	of	of	IN
cord-321607-3r736dnk	36	17	two	two	CD
cord-321607-3r736dnk	36	18	or	or	CC
cord-321607-3r736dnk	36	19	more	more	JJR
cord-321607-3r736dnk	36	20	monomers	monomer	NNS
cord-321607-3r736dnk	36	21	and	and	CC
cord-321607-3r736dnk	36	22	that	that	IN
cord-321607-3r736dnk	36	23	at	at	IN
cord-321607-3r736dnk	36	24	micromolar	micromolar	JJ
cord-321607-3r736dnk	36	25	concentrations	concentration	NNS
cord-321607-3r736dnk	36	26	of	of	IN
cord-321607-3r736dnk	36	27	RNase	RNase	NNP
cord-321607-3r736dnk	36	28	-	-	HYPH
cord-321607-3r736dnk	36	29	L	l	NN
cord-321607-3r736dnk	36	30	,	,	,
cord-321607-3r736dnk	36	31	2	2	CD
cord-321607-3r736dnk	36	32	-	-	HYPH
cord-321607-3r736dnk	36	33	5A	5a	NN
cord-321607-3r736dnk	36	34	is	be	VBZ
cord-321607-3r736dnk	36	35	dispensable	dispensable	JJ
cord-321607-3r736dnk	36	36	for	for	IN
cord-321607-3r736dnk	36	37	this	this	DT
cord-321607-3r736dnk	36	38	oligomerization	oligomerization	NN
cord-321607-3r736dnk	36	39	[	[	-LRB-
cord-321607-3r736dnk	36	40	49	49	CD
cord-321607-3r736dnk	36	41	]	]	-RRB-
cord-321607-3r736dnk	36	42	.	.	.
cord-321607-3r736dnk	37	1	Whether	whether	IN
cord-321607-3r736dnk	37	2	physiologic	physiologic	JJ
cord-321607-3r736dnk	37	3	concentrations	concentration	NNS
cord-321607-3r736dnk	37	4	of	of	IN
cord-321607-3r736dnk	37	5	RNase	RNase	NNP
cord-321607-3r736dnk	37	6	-	-	HYPH
cord-321607-3r736dnk	37	7	L	l	NN
cord-321607-3r736dnk	37	8	reach	reach	VB
cord-321607-3r736dnk	37	9	these	these	DT
cord-321607-3r736dnk	37	10	levels	level	NNS
cord-321607-3r736dnk	37	11	is	be	VBZ
cord-321607-3r736dnk	37	12	unknown	unknown	JJ
cord-321607-3r736dnk	37	13	.	.	.
cord-321607-3r736dnk	38	1	Once	once	RB
cord-321607-3r736dnk	38	2	active	active	JJ
cord-321607-3r736dnk	38	3	,	,	,
cord-321607-3r736dnk	38	4	RNase	RNase	NNP
cord-321607-3r736dnk	38	5	-	-	HYPH
cord-321607-3r736dnk	38	6	L	L	NNP
cord-321607-3r736dnk	38	7	cleaves	cleave	VBZ
cord-321607-3r736dnk	38	8	ssRNA	ssRNA	''
cord-321607-3r736dnk	38	9	,	,	,
cord-321607-3r736dnk	38	10	including	include	VBG
cord-321607-3r736dnk	38	11	cellular	cellular	JJ
cord-321607-3r736dnk	38	12	mRNA	mRNA	NNP
cord-321607-3r736dnk	38	13	and	and	CC
cord-321607-3r736dnk	38	14	rRNA	rrna	NN
cord-321607-3r736dnk	38	15	as	as	RB
cord-321607-3r736dnk	38	16	well	well	RB
cord-321607-3r736dnk	38	17	as	as	IN
cord-321607-3r736dnk	38	18	microbial	microbial	JJ
cord-321607-3r736dnk	38	19	RNAs	rna	NNS
cord-321607-3r736dnk	38	20	[	[	-LRB-
cord-321607-3r736dnk	38	21	51	51	CD
cord-321607-3r736dnk	38	22	,	,	,
cord-321607-3r736dnk	38	23	52	52	CD
cord-321607-3r736dnk	38	24	]	]	-RRB-
cord-321607-3r736dnk	38	25	.	.	.
cord-321607-3r736dnk	39	1	The	the	DT
cord-321607-3r736dnk	39	2	targeting	targeting	NN
cord-321607-3r736dnk	39	3	of	of	IN
cord-321607-3r736dnk	39	4	microbial	microbial	JJ
cord-321607-3r736dnk	39	5	RNAs	rna	NNS
cord-321607-3r736dnk	39	6	has	have	VBZ
cord-321607-3r736dnk	39	7	a	a	DT
cord-321607-3r736dnk	39	8	significant	significant	JJ
cord-321607-3r736dnk	39	9	impact	impact	NN
cord-321607-3r736dnk	39	10	on	on	IN
cord-321607-3r736dnk	39	11	the	the	DT
cord-321607-3r736dnk	39	12	ability	ability	NN
cord-321607-3r736dnk	39	13	of	of	IN
cord-321607-3r736dnk	39	14	the	the	DT
cord-321607-3r736dnk	39	15	virus	virus	NN
cord-321607-3r736dnk	39	16	or	or	CC
cord-321607-3r736dnk	39	17	bacterium	bacterium	NN
cord-321607-3r736dnk	39	18	to	to	TO
cord-321607-3r736dnk	39	19	replicate	replicate	VB
cord-321607-3r736dnk	39	20	,	,	,
cord-321607-3r736dnk	39	21	as	as	IN
cord-321607-3r736dnk	39	22	does	do	VBZ
cord-321607-3r736dnk	39	23	the	the	DT
cord-321607-3r736dnk	39	24	inhibition	inhibition	NN
cord-321607-3r736dnk	39	25	of	of	IN
cord-321607-3r736dnk	39	26	cellular	cellular	JJ
cord-321607-3r736dnk	39	27	translation	translation	NN
cord-321607-3r736dnk	39	28	resulting	result	VBG
cord-321607-3r736dnk	39	29	from	from	IN
cord-321607-3r736dnk	39	30	the	the	DT
cord-321607-3r736dnk	39	31	cleavage	cleavage	NN
cord-321607-3r736dnk	39	32	of	of	IN
cord-321607-3r736dnk	39	33	rRNA	rrna	NN
cord-321607-3r736dnk	39	34	and	and	CC
cord-321607-3r736dnk	39	35	ribosomal	ribosomal	JJ
cord-321607-3r736dnk	39	36	protein	protein	NN
cord-321607-3r736dnk	39	37	transcripts	transcript	NNS
cord-321607-3r736dnk	39	38	[	[	-LRB-
cord-321607-3r736dnk	39	39	6	6	CD
cord-321607-3r736dnk	39	40	,	,	,
cord-321607-3r736dnk	39	41	26	26	CD
cord-321607-3r736dnk	39	42	,	,	,
cord-321607-3r736dnk	39	43	41	41	CD
cord-321607-3r736dnk	39	44	,	,	,
cord-321607-3r736dnk	39	45	53	53	CD
cord-321607-3r736dnk	39	46	]	]	-RRB-
cord-321607-3r736dnk	39	47	.	.	.
cord-321607-3r736dnk	40	1	mRNA	mrna	NN
cord-321607-3r736dnk	40	2	targeting	targeting	NN
cord-321607-3r736dnk	40	3	can	can	MD
cord-321607-3r736dnk	40	4	facilitate	facilitate	VB
cord-321607-3r736dnk	40	5	RNase	RNase	NNP
cord-321607-3r736dnk	40	6	-	-	HYPH
cord-321607-3r736dnk	40	7	L	l	NN
cord-321607-3r736dnk	40	8	-	-	HYPH
cord-321607-3r736dnk	40	9	dependent	dependent	JJ
cord-321607-3r736dnk	40	10	regulation	regulation	NN
cord-321607-3r736dnk	40	11	of	of	IN
cord-321607-3r736dnk	40	12	gene	gene	NN
cord-321607-3r736dnk	40	13	expression	expression	NN
cord-321607-3r736dnk	40	14	through	through	IN
cord-321607-3r736dnk	40	15	direct	direct	JJ
cord-321607-3r736dnk	40	16	cleavage	cleavage	NN
cord-321607-3r736dnk	40	17	of	of	IN
cord-321607-3r736dnk	40	18	transcripts	transcript	NNS
cord-321607-3r736dnk	40	19	or	or	CC
cord-321607-3r736dnk	40	20	indirectly	indirectly	RB
cord-321607-3r736dnk	40	21	through	through	IN
cord-321607-3r736dnk	40	22	the	the	DT
cord-321607-3r736dnk	40	23	destabilization	destabilization	NN
cord-321607-3r736dnk	40	24	of	of	IN
cord-321607-3r736dnk	40	25	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	40	26	regulators	regulator	NNS
cord-321607-3r736dnk	40	27	[	[	-LRB-
cord-321607-3r736dnk	40	28	54	54	CD
cord-321607-3r736dnk	40	29	]	]	-RRB-
cord-321607-3r736dnk	40	30	.	.	.
cord-321607-3r736dnk	41	1	Historically	historically	RB
cord-321607-3r736dnk	41	2	,	,	,
cord-321607-3r736dnk	41	3	this	this	DT
cord-321607-3r736dnk	41	4	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	41	5	activity	activity	NN
cord-321607-3r736dnk	41	6	has	have	VBZ
cord-321607-3r736dnk	41	7	been	be	VBN
cord-321607-3r736dnk	41	8	considered	consider	VBN
cord-321607-3r736dnk	41	9	the	the	DT
cord-321607-3r736dnk	41	10	major	major	JJ
cord-321607-3r736dnk	41	11	mediator	mediator	NN
cord-321607-3r736dnk	41	12	of	of	IN
cord-321607-3r736dnk	41	13	the	the	DT
cord-321607-3r736dnk	41	14	biological	biological	JJ
cord-321607-3r736dnk	41	15	activities	activity	NNS
cord-321607-3r736dnk	41	16	of	of	IN
cord-321607-3r736dnk	41	17	RNase	RNase	NNP
cord-321607-3r736dnk	41	18	-	-	HYPH
cord-321607-3r736dnk	41	19	L.	L.	NNP
cord-321607-3r736dnk	41	20	 	 	_SP
cord-321607-3r736dnk	42	1	In	in	IN
cord-321607-3r736dnk	42	2	the	the	DT
cord-321607-3r736dnk	42	3	event	event	NN
cord-321607-3r736dnk	42	4	of	of	IN
cord-321607-3r736dnk	42	5	pathogen	pathogen	NN
cord-321607-3r736dnk	42	6	infection	infection	NN
cord-321607-3r736dnk	42	7	,	,	,
cord-321607-3r736dnk	42	8	rapid	rapid	JJ
cord-321607-3r736dnk	42	9	activation	activation	NN
cord-321607-3r736dnk	42	10	of	of	IN
cord-321607-3r736dnk	42	11	RNase	RNase	NNP
cord-321607-3r736dnk	42	12	-	-	HYPH
cord-321607-3r736dnk	42	13	L	L	NNP
cord-321607-3r736dnk	42	14	increases	increase	VBZ
cord-321607-3r736dnk	42	15	the	the	DT
cord-321607-3r736dnk	42	16	chance	chance	NN
cord-321607-3r736dnk	42	17	for	for	IN
cord-321607-3r736dnk	42	18	clearance	clearance	NN
cord-321607-3r736dnk	42	19	and	and	CC
cord-321607-3r736dnk	42	20	host	host	NN
cord-321607-3r736dnk	42	21	survival	survival	NN
cord-321607-3r736dnk	42	22	;	;	:
cord-321607-3r736dnk	42	23	however	however	RB
cord-321607-3r736dnk	42	24	,	,	,
cord-321607-3r736dnk	42	25	uncontrolled	uncontrolled	JJ
cord-321607-3r736dnk	42	26	activation	activation	NN
cord-321607-3r736dnk	42	27	of	of	IN
cord-321607-3r736dnk	42	28	RNase	RNase	NNP
cord-321607-3r736dnk	42	29	-	-	HYPH
cord-321607-3r736dnk	42	30	L	L	NNP
cord-321607-3r736dnk	42	31	could	could	MD
cord-321607-3r736dnk	42	32	lead	lead	VB
cord-321607-3r736dnk	42	33	to	to	IN
cord-321607-3r736dnk	42	34	cell	cell	NN
cord-321607-3r736dnk	42	35	death	death	NN
cord-321607-3r736dnk	42	36	or	or	CC
cord-321607-3r736dnk	42	37	dysregulated	dysregulate	VBN
cord-321607-3r736dnk	42	38	gene	gene	NN
cord-321607-3r736dnk	42	39	expression	expression	NN
cord-321607-3r736dnk	42	40	[	[	-LRB-
cord-321607-3r736dnk	42	41	13	13	CD
cord-321607-3r736dnk	42	42	,	,	,
cord-321607-3r736dnk	42	43	15	15	CD
cord-321607-3r736dnk	42	44	,	,	,
cord-321607-3r736dnk	42	45	26	26	CD
cord-321607-3r736dnk	42	46	,	,	,
cord-321607-3r736dnk	42	47	55	55	CD
cord-321607-3r736dnk	42	48	]	]	-RRB-
cord-321607-3r736dnk	42	49	.	.	.
cord-321607-3r736dnk	43	1	Therefore	therefore	RB
cord-321607-3r736dnk	43	2	,	,	,
cord-321607-3r736dnk	43	3	RNase	RNase	NNP
cord-321607-3r736dnk	43	4	-	-	HYPH
cord-321607-3r736dnk	43	5	L	L	NNP
cord-321607-3r736dnk	43	6	is	be	VBZ
cord-321607-3r736dnk	43	7	tightly	tightly	RB
cord-321607-3r736dnk	43	8	regulated	regulate	VBN
cord-321607-3r736dnk	43	9	by	by	IN
cord-321607-3r736dnk	43	10	multiple	multiple	JJ
cord-321607-3r736dnk	43	11	mechanisms	mechanism	NNS
cord-321607-3r736dnk	43	12	in	in	IN
cord-321607-3r736dnk	43	13	order	order	NN
cord-321607-3r736dnk	43	14	to	to	TO
cord-321607-3r736dnk	43	15	maintain	maintain	VB
cord-321607-3r736dnk	43	16	cell	cell	NN
cord-321607-3r736dnk	43	17	homeostasis	homeostasis	NN
cord-321607-3r736dnk	43	18	.	.	.
cord-321607-3r736dnk	44	1	RNase	RNase	NNP
cord-321607-3r736dnk	44	2	-	-	HYPH
cord-321607-3r736dnk	44	3	L	L	NNP
cord-321607-3r736dnk	44	4	is	be	VBZ
cord-321607-3r736dnk	44	5	typically	typically	RB
cord-321607-3r736dnk	44	6	expressed	express	VBN
cord-321607-3r736dnk	44	7	at	at	IN
cord-321607-3r736dnk	44	8	low	low	JJ
cord-321607-3r736dnk	44	9	levels	level	NNS
cord-321607-3r736dnk	44	10	in	in	IN
cord-321607-3r736dnk	44	11	most	most	JJS
cord-321607-3r736dnk	44	12	mammalian	mammalian	JJ
cord-321607-3r736dnk	44	13	cell	cell	NN
cord-321607-3r736dnk	44	14	types	type	NNS
cord-321607-3r736dnk	44	15	.	.	.
cord-321607-3r736dnk	45	1	It	-PRON-	PRP
cord-321607-3r736dnk	45	2	is	be	VBZ
cord-321607-3r736dnk	45	3	marginally	marginally	RB
cord-321607-3r736dnk	45	4	induced	induce	VBN
cord-321607-3r736dnk	45	5	by	by	IN
cord-321607-3r736dnk	45	6	IFNα	IFNα	NNP
cord-321607-3r736dnk	45	7	/	/	SYM
cord-321607-3r736dnk	45	8	β	β	NNP
cord-321607-3r736dnk	45	9	and	and	CC
cord-321607-3r736dnk	45	10	IFNγ	IFNγ	NNS
cord-321607-3r736dnk	45	11	,	,	,
cord-321607-3r736dnk	45	12	and	and	CC
cord-321607-3r736dnk	45	13	sequence	sequence	NN
cord-321607-3r736dnk	45	14	analysis	analysis	NN
cord-321607-3r736dnk	45	15	primarily	primarily	RB
cord-321607-3r736dnk	45	16	indicates	indicate	VBZ
cord-321607-3r736dnk	45	17	tissue	tissue	NN
cord-321607-3r736dnk	45	18	-	-	HYPH
cord-321607-3r736dnk	45	19	specific	specific	JJ
cord-321607-3r736dnk	45	20	and	and	CC
cord-321607-3r736dnk	45	21	ubiquitous	ubiquitous	JJ
cord-321607-3r736dnk	45	22	elements	element	NNS
cord-321607-3r736dnk	45	23	in	in	IN
cord-321607-3r736dnk	45	24	the	the	DT
cord-321607-3r736dnk	45	25	promoter	promoter	NN
cord-321607-3r736dnk	45	26	[	[	-LRB-
cord-321607-3r736dnk	45	27	1	1	CD
cord-321607-3r736dnk	45	28	,	,	,
cord-321607-3r736dnk	45	29	2	2	CD
cord-321607-3r736dnk	45	30	,	,	,
cord-321607-3r736dnk	45	31	56	56	CD
cord-321607-3r736dnk	45	32	]	]	-RRB-
cord-321607-3r736dnk	45	33	.	.	.
cord-321607-3r736dnk	46	1	Amongst	amongst	IN
cord-321607-3r736dnk	46	2	these	these	DT
cord-321607-3r736dnk	46	3	were	be	VBD
cord-321607-3r736dnk	46	4	sites	site	NNS
cord-321607-3r736dnk	46	5	for	for	IN
cord-321607-3r736dnk	46	6	the	the	DT
cord-321607-3r736dnk	46	7	specificity	specificity	NN
cord-321607-3r736dnk	46	8	protein	protein	NN
cord-321607-3r736dnk	46	9	1	1	CD
cord-321607-3r736dnk	46	10	(	(	-LRB-
cord-321607-3r736dnk	46	11	Sp1	Sp1	NNP
cord-321607-3r736dnk	46	12	)	)	-RRB-
cord-321607-3r736dnk	46	13	transcription	transcription	NN
cord-321607-3r736dnk	46	14	factor	factor	NN
cord-321607-3r736dnk	46	15	,	,	,
cord-321607-3r736dnk	46	16	which	which	WDT
cord-321607-3r736dnk	46	17	are	be	VBP
cord-321607-3r736dnk	46	18	present	present	JJ
cord-321607-3r736dnk	46	19	in	in	IN
cord-321607-3r736dnk	46	20	many	many	JJ
cord-321607-3r736dnk	46	21	housekeeping	housekeeping	NN
cord-321607-3r736dnk	46	22	genes	gene	NNS
cord-321607-3r736dnk	46	23	.	.	.
cord-321607-3r736dnk	47	1	Recent	recent	JJ
cord-321607-3r736dnk	47	2	findings	finding	NNS
cord-321607-3r736dnk	47	3	show	show	VBP
cord-321607-3r736dnk	47	4	that	that	IN
cord-321607-3r736dnk	47	5	overexpression	overexpression	NN
cord-321607-3r736dnk	47	6	of	of	IN
cord-321607-3r736dnk	47	7	Sp1	Sp1	NNP
cord-321607-3r736dnk	47	8	,	,	,
cord-321607-3r736dnk	47	9	which	which	WDT
cord-321607-3r736dnk	47	10	is	be	VBZ
cord-321607-3r736dnk	47	11	associated	associate	VBN
cord-321607-3r736dnk	47	12	with	with	IN
cord-321607-3r736dnk	47	13	tumorigenesis	tumorigenesis	NN
cord-321607-3r736dnk	47	14	,	,	,
cord-321607-3r736dnk	47	15	can	can	MD
cord-321607-3r736dnk	47	16	induce	induce	VB
cord-321607-3r736dnk	47	17	RNase	RNase	NNP
cord-321607-3r736dnk	47	18	-	-	HYPH
cord-321607-3r736dnk	47	19	L	l	NN
cord-321607-3r736dnk	47	20	and	and	CC
cord-321607-3r736dnk	47	21	many	many	JJ
cord-321607-3r736dnk	47	22	other	other	JJ
cord-321607-3r736dnk	48	1	RIG	rig	NN
cord-321607-3r736dnk	48	2	-	-	:
cord-321607-3r736dnk	48	3	I	-PRON-	PRP
cord-321607-3r736dnk	48	4	pathway	pathway	NN
cord-321607-3r736dnk	48	5	members	member	NNS
cord-321607-3r736dnk	48	6	[	[	-LRB-
cord-321607-3r736dnk	48	7	57	57	CD
cord-321607-3r736dnk	48	8	]	]	-RRB-
cord-321607-3r736dnk	48	9	.	.	.
cord-321607-3r736dnk	49	1	Although	although	IN
cord-321607-3r736dnk	49	2	this	this	DT
cord-321607-3r736dnk	49	3	may	may	MD
cord-321607-3r736dnk	49	4	appear	appear	VB
cord-321607-3r736dnk	49	5	to	to	TO
cord-321607-3r736dnk	49	6	contradict	contradict	VB
cord-321607-3r736dnk	49	7	the	the	DT
cord-321607-3r736dnk	49	8	role	role	NN
cord-321607-3r736dnk	49	9	of	of	IN
cord-321607-3r736dnk	49	10	RNase	RNase	NNP
cord-321607-3r736dnk	49	11	-	-	HYPH
cord-321607-3r736dnk	49	12	L	L	NNP
cord-321607-3r736dnk	49	13	as	as	IN
cord-321607-3r736dnk	49	14	a	a	DT
cord-321607-3r736dnk	49	15	tumor	tumor	NN
cord-321607-3r736dnk	49	16	suppressor	suppressor	NN
cord-321607-3r736dnk	49	17	,	,	,
cord-321607-3r736dnk	49	18	our	-PRON-	PRP$
cord-321607-3r736dnk	49	19	lab	lab	NN
cord-321607-3r736dnk	49	20	has	have	VBZ
cord-321607-3r736dnk	49	21	shown	show	VBN
cord-321607-3r736dnk	49	22	that	that	IN
cord-321607-3r736dnk	49	23	RNase	RNase	NNP
cord-321607-3r736dnk	49	24	-	-	HYPH
cord-321607-3r736dnk	49	25	L	L	NNP
cord-321607-3r736dnk	49	26	can	can	MD
cord-321607-3r736dnk	49	27	have	have	VB
cord-321607-3r736dnk	49	28	oncogenic	oncogenic	JJ
cord-321607-3r736dnk	49	29	activity	activity	NN
cord-321607-3r736dnk	49	30	in	in	IN
cord-321607-3r736dnk	49	31	chronic	chronic	JJ
cord-321607-3r736dnk	49	32	myelogenous	myelogenous	NN
cord-321607-3r736dnk	49	33	leukemia	leukemia	NN
cord-321607-3r736dnk	49	34	and	and	CC
cord-321607-3r736dnk	49	35	this	this	DT
cord-321607-3r736dnk	49	36	may	may	MD
cord-321607-3r736dnk	49	37	contribute	contribute	VB
cord-321607-3r736dnk	49	38	to	to	IN
cord-321607-3r736dnk	49	39	that	that	DT
cord-321607-3r736dnk	49	40	novel	novel	JJ
cord-321607-3r736dnk	49	41	function	function	NN
cord-321607-3r736dnk	49	42	in	in	IN
cord-321607-3r736dnk	49	43	certain	certain	JJ
cord-321607-3r736dnk	49	44	cell	cell	NN
cord-321607-3r736dnk	49	45	types	type	NNS
cord-321607-3r736dnk	49	46	[	[	-LRB-
cord-321607-3r736dnk	49	47	58	58	CD
cord-321607-3r736dnk	49	48	]	]	-RRB-
cord-321607-3r736dnk	49	49	.	.	.
cord-321607-3r736dnk	50	1	In	in	IN
cord-321607-3r736dnk	50	2	addition	addition	NN
cord-321607-3r736dnk	50	3	to	to	IN
cord-321607-3r736dnk	50	4	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	50	5	control	control	NN
cord-321607-3r736dnk	50	6	,	,	,
cord-321607-3r736dnk	50	7	RNase	RNase	NNP
cord-321607-3r736dnk	50	8	-	-	HYPH
cord-321607-3r736dnk	50	9	L	L	NNP
cord-321607-3r736dnk	50	10	mRNA	mrna	NN
cord-321607-3r736dnk	50	11	is	be	VBZ
cord-321607-3r736dnk	50	12	also	also	RB
cord-321607-3r736dnk	50	13	regulated	regulate	VBN
cord-321607-3r736dnk	50	14	at	at	IN
cord-321607-3r736dnk	50	15	the	the	DT
cord-321607-3r736dnk	50	16	post	post	JJ
cord-321607-3r736dnk	50	17	-	-	JJ
cord-321607-3r736dnk	50	18	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	50	19	level	level	NN
cord-321607-3r736dnk	50	20	by	by	IN
cord-321607-3r736dnk	50	21	the	the	DT
cord-321607-3r736dnk	50	22	RNA	RNA	NNP
cord-321607-3r736dnk	50	23	-	-	HYPH
cord-321607-3r736dnk	50	24	binding	bind	VBG
cord-321607-3r736dnk	50	25	protein	protein	NN
cord-321607-3r736dnk	50	26	(	(	-LRB-
cord-321607-3r736dnk	50	27	RBP	RBP	NNP
cord-321607-3r736dnk	50	28	)	)	-RRB-
cord-321607-3r736dnk	50	29	human	human	JJ
cord-321607-3r736dnk	50	30	antigen	antigen	NN
cord-321607-3r736dnk	50	31	R	r	NN
cord-321607-3r736dnk	50	32	(	(	-LRB-
cord-321607-3r736dnk	50	33	HuR	HuR	NNP
cord-321607-3r736dnk	50	34	)	)	-RRB-
cord-321607-3r736dnk	50	35	[	[	-LRB-
cord-321607-3r736dnk	50	36	59	59	CD
cord-321607-3r736dnk	50	37	]	]	-RRB-
cord-321607-3r736dnk	50	38	.	.	.
cord-321607-3r736dnk	51	1	HuR	HuR	NNP
cord-321607-3r736dnk	51	2	binds	bind	VBZ
cord-321607-3r736dnk	51	3	to	to	IN
cord-321607-3r736dnk	51	4	AU	AU	NNP
cord-321607-3r736dnk	51	5	-	-	HYPH
cord-321607-3r736dnk	51	6	rich	rich	JJ
cord-321607-3r736dnk	51	7	elements	element	NNS
cord-321607-3r736dnk	51	8	(	(	-LRB-
cord-321607-3r736dnk	51	9	ARE	are	VBP
cord-321607-3r736dnk	51	10	)	)	-RRB-
cord-321607-3r736dnk	51	11	typically	typically	RB
cord-321607-3r736dnk	51	12	found	find	VBN
cord-321607-3r736dnk	51	13	in	in	IN
cord-321607-3r736dnk	51	14	the	the	DT
cord-321607-3r736dnk	51	15	3	3	CD
cord-321607-3r736dnk	51	16	1	1	CD
cord-321607-3r736dnk	51	17	UTRs	utr	NNS
cord-321607-3r736dnk	51	18	of	of	IN
cord-321607-3r736dnk	51	19	post	post	NN
cord-321607-3r736dnk	51	20	-	-	NN
cord-321607-3r736dnk	51	21	transcriptionally	transcriptionally	RB
cord-321607-3r736dnk	51	22	regulated	regulate	VBN
cord-321607-3r736dnk	51	23	mRNAs	mRNAs	NNPS
cord-321607-3r736dnk	51	24	,	,	,
cord-321607-3r736dnk	51	25	and	and	CC
cord-321607-3r736dnk	51	26	stabilizes	stabilize	VBZ
cord-321607-3r736dnk	51	27	them	-PRON-	PRP
cord-321607-3r736dnk	51	28	[	[	-LRB-
cord-321607-3r736dnk	51	29	60	60	CD
cord-321607-3r736dnk	51	30	]	]	-RRB-
cord-321607-3r736dnk	51	31	.	.	.
cord-321607-3r736dnk	52	1	RNase	RNase	NNP
cord-321607-3r736dnk	52	2	-	-	HYPH
cord-321607-3r736dnk	52	3	L	L	NNP
cord-321607-3r736dnk	52	4	has	have	VBZ
cord-321607-3r736dnk	52	5	eight	eight	CD
cord-321607-3r736dnk	52	6	AREs	are	NNS
cord-321607-3r736dnk	52	7	,	,	,
cord-321607-3r736dnk	52	8	and	and	CC
cord-321607-3r736dnk	52	9	deletion	deletion	NN
cord-321607-3r736dnk	52	10	mapping	mapping	NN
cord-321607-3r736dnk	52	11	indicates	indicate	VBZ
cord-321607-3r736dnk	52	12	that	that	IN
cord-321607-3r736dnk	52	13	there	there	EX
cord-321607-3r736dnk	52	14	are	be	VBP
cord-321607-3r736dnk	52	15	both	both	DT
cord-321607-3r736dnk	52	16	positive	positive	JJ
cord-321607-3r736dnk	52	17	and	and	CC
cord-321607-3r736dnk	52	18	negative	negative	JJ
cord-321607-3r736dnk	52	19	regulatory	regulatory	JJ
cord-321607-3r736dnk	52	20	elements	element	NNS
cord-321607-3r736dnk	52	21	in	in	IN
cord-321607-3r736dnk	52	22	the	the	DT
cord-321607-3r736dnk	52	23	3	3	CD
cord-321607-3r736dnk	52	24	1	1	CD
cord-321607-3r736dnk	52	25	UTR	UTR	NNP
cord-321607-3r736dnk	52	26	.	.	.
cord-321607-3r736dnk	53	1	The	the	DT
cord-321607-3r736dnk	53	2	two	two	CD
cord-321607-3r736dnk	53	3	AREs	are	NNS
cord-321607-3r736dnk	53	4	closest	close	JJS
cord-321607-3r736dnk	53	5	to	to	IN
cord-321607-3r736dnk	53	6	the	the	DT
cord-321607-3r736dnk	53	7	3	3	CD
cord-321607-3r736dnk	53	8	1	1	CD
cord-321607-3r736dnk	53	9	terminus	terminus	NN
cord-321607-3r736dnk	53	10	are	be	VBP
cord-321607-3r736dnk	53	11	stabilized	stabilize	VBN
cord-321607-3r736dnk	53	12	by	by	IN
cord-321607-3r736dnk	53	13	HuR	hur	NN
cord-321607-3r736dnk	53	14	and	and	CC
cord-321607-3r736dnk	53	15	result	result	VB
cord-321607-3r736dnk	53	16	in	in	IN
cord-321607-3r736dnk	53	17	a	a	DT
cord-321607-3r736dnk	53	18	several	several	JJ
cord-321607-3r736dnk	53	19	-	-	HYPH
cord-321607-3r736dnk	53	20	fold	fold	JJ
cord-321607-3r736dnk	53	21	increase	increase	NN
cord-321607-3r736dnk	53	22	in	in	IN
cord-321607-3r736dnk	53	23	RNase	RNase	NNP
cord-321607-3r736dnk	53	24	-	-	HYPH
cord-321607-3r736dnk	53	25	L	l	NN
cord-321607-3r736dnk	53	26	expression	expression	NN
cord-321607-3r736dnk	53	27	[	[	-LRB-
cord-321607-3r736dnk	53	28	59	59	CD
cord-321607-3r736dnk	53	29	]	]	-RRB-
cord-321607-3r736dnk	53	30	.	.	.
cord-321607-3r736dnk	54	1	Even	even	RB
cord-321607-3r736dnk	54	2	low	low	JJ
cord-321607-3r736dnk	54	3	-	-	HYPH
cord-321607-3r736dnk	54	4	to	to	IN
cord-321607-3r736dnk	54	5	-	-	HYPH
cord-321607-3r736dnk	54	6	moderate	moderate	JJ
cord-321607-3r736dnk	54	7	changes	change	NNS
cord-321607-3r736dnk	54	8	in	in	IN
cord-321607-3r736dnk	54	9	RNase	RNase	NNP
cord-321607-3r736dnk	54	10	-	-	HYPH
cord-321607-3r736dnk	54	11	L	l	NN
cord-321607-3r736dnk	54	12	expression	expression	NN
cord-321607-3r736dnk	54	13	yield	yield	VB
cord-321607-3r736dnk	54	14	significant	significant	JJ
cord-321607-3r736dnk	54	15	functional	functional	JJ
cord-321607-3r736dnk	54	16	impact	impact	NN
cord-321607-3r736dnk	54	17	as	as	IN
cord-321607-3r736dnk	54	18	RNA	RNA	NNP
cord-321607-3r736dnk	54	19	cleavage	cleavage	NN
cord-321607-3r736dnk	54	20	activity	activity	NN
cord-321607-3r736dnk	54	21	is	be	VBZ
cord-321607-3r736dnk	54	22	disproportionately	disproportionately	RB
cord-321607-3r736dnk	54	23	enhanced	enhance	VBN
cord-321607-3r736dnk	54	24	with	with	IN
cord-321607-3r736dnk	54	25	even	even	RB
cord-321607-3r736dnk	54	26	two	two	CD
cord-321607-3r736dnk	54	27	-	-	HYPH
cord-321607-3r736dnk	54	28	fold	fold	JJ
cord-321607-3r736dnk	54	29	increases	increase	NNS
cord-321607-3r736dnk	54	30	in	in	IN
cord-321607-3r736dnk	54	31	expression	expression	NN
cord-321607-3r736dnk	54	32	[	[	-LRB-
cord-321607-3r736dnk	54	33	49	49	CD
cord-321607-3r736dnk	54	34	]	]	-RRB-
cord-321607-3r736dnk	54	35	.	.	.
cord-321607-3r736dnk	55	1	Once	once	IN
cord-321607-3r736dnk	55	2	the	the	DT
cord-321607-3r736dnk	55	3	protein	protein	NN
cord-321607-3r736dnk	55	4	is	be	VBZ
cord-321607-3r736dnk	55	5	made	make	VBN
cord-321607-3r736dnk	55	6	,	,	,
cord-321607-3r736dnk	55	7	RNase	RNase	NNP
cord-321607-3r736dnk	55	8	-	-	HYPH
cord-321607-3r736dnk	55	9	L	L	NNP
cord-321607-3r736dnk	55	10	is	be	VBZ
cord-321607-3r736dnk	55	11	susceptible	susceptible	JJ
cord-321607-3r736dnk	55	12	to	to	IN
cord-321607-3r736dnk	55	13	two	two	CD
cord-321607-3r736dnk	55	14	forms	form	NNS
cord-321607-3r736dnk	55	15	of	of	IN
cord-321607-3r736dnk	55	16	post	post	JJ
cord-321607-3r736dnk	55	17	-	-	JJ
cord-321607-3r736dnk	55	18	translational	translational	JJ
cord-321607-3r736dnk	55	19	modification	modification	NN
cord-321607-3r736dnk	55	20	:	:	:
cord-321607-3r736dnk	55	21	ubiquitination	ubiquitination	NN
cord-321607-3r736dnk	55	22	and	and	CC
cord-321607-3r736dnk	55	23	hydroxylation	hydroxylation	NN
cord-321607-3r736dnk	55	24	.	.	.
cord-321607-3r736dnk	56	1	Chase	Chase	NNP
cord-321607-3r736dnk	56	2	et	et	NNP
cord-321607-3r736dnk	56	3	al	al	NNP
cord-321607-3r736dnk	56	4	.	.	.
cord-321607-3r736dnk	57	1	[	[	-LRB-
cord-321607-3r736dnk	57	2	61	61	CD
cord-321607-3r736dnk	57	3	]	]	-RRB-
cord-321607-3r736dnk	57	4	found	find	VBD
cord-321607-3r736dnk	57	5	that	that	DT
cord-321607-3r736dnk	57	6	treatment	treatment	NN
cord-321607-3r736dnk	57	7	of	of	IN
cord-321607-3r736dnk	57	8	L929	l929	JJ
cord-321607-3r736dnk	57	9	cells	cell	NNS
cord-321607-3r736dnk	57	10	with	with	IN
cord-321607-3r736dnk	57	11	the	the	DT
cord-321607-3r736dnk	57	12	phorbol	phorbol	NNP
cord-321607-3r736dnk	57	13	ester	ester	NNP
cord-321607-3r736dnk	57	14	phorbol-12-myristate-13	phorbol-12-myristate-13	NNPS
cord-321607-3r736dnk	57	15	acetate	acetate	NN
cord-321607-3r736dnk	57	16	(	(	-LRB-
cord-321607-3r736dnk	57	17	PMA	PMA	NNP
cord-321607-3r736dnk	57	18	)	)	-RRB-
cord-321607-3r736dnk	57	19	resulted	result	VBD
cord-321607-3r736dnk	57	20	in	in	IN
cord-321607-3r736dnk	57	21	the	the	DT
cord-321607-3r736dnk	57	22	rapid	rapid	JJ
cord-321607-3r736dnk	57	23	and	and	CC
cord-321607-3r736dnk	57	24	almost	almost	RB
cord-321607-3r736dnk	57	25	complete	complete	JJ
cord-321607-3r736dnk	57	26	reduction	reduction	NN
cord-321607-3r736dnk	57	27	of	of	IN
cord-321607-3r736dnk	57	28	RNase	RNase	NNP
cord-321607-3r736dnk	57	29	-	-	HYPH
cord-321607-3r736dnk	57	30	L	l	NN
cord-321607-3r736dnk	57	31	protein	protein	NN
cord-321607-3r736dnk	57	32	levels	level	NNS
cord-321607-3r736dnk	57	33	.	.	.
cord-321607-3r736dnk	58	1	This	this	DT
cord-321607-3r736dnk	58	2	degradation	degradation	NN
cord-321607-3r736dnk	58	3	was	be	VBD
cord-321607-3r736dnk	58	4	ablated	ablate	VBN
cord-321607-3r736dnk	58	5	by	by	IN
cord-321607-3r736dnk	58	6	treatment	treatment	NN
cord-321607-3r736dnk	58	7	with	with	IN
cord-321607-3r736dnk	58	8	proteasome	proteasome	NN
cord-321607-3r736dnk	58	9	inhibitors	inhibitor	NNS
cord-321607-3r736dnk	58	10	.	.	.
cord-321607-3r736dnk	59	1	Similarly	similarly	RB
cord-321607-3r736dnk	59	2	,	,	,
cord-321607-3r736dnk	59	3	ubiquitin	ubiquitin	JJ
cord-321607-3r736dnk	59	4	modification	modification	NN
cord-321607-3r736dnk	59	5	of	of	IN
cord-321607-3r736dnk	59	6	RNase	RNase	NNP
cord-321607-3r736dnk	59	7	-	-	HYPH
cord-321607-3r736dnk	59	8	L	L	NNP
cord-321607-3r736dnk	59	9	was	be	VBD
cord-321607-3r736dnk	59	10	seen	see	VBN
cord-321607-3r736dnk	59	11	in	in	IN
cord-321607-3r736dnk	59	12	the	the	DT
cord-321607-3r736dnk	59	13	muscle	muscle	NN
cord-321607-3r736dnk	59	14	tissue	tissue	NN
cord-321607-3r736dnk	59	15	of	of	IN
cord-321607-3r736dnk	59	16	a	a	DT
cord-321607-3r736dnk	59	17	transgenic	transgenic	JJ
cord-321607-3r736dnk	59	18	β5	β5	NNP
cord-321607-3r736dnk	59	19	t	t	NNP
cord-321607-3r736dnk	59	20	mouse	mouse	NN
cord-321607-3r736dnk	59	21	model	model	NN
cord-321607-3r736dnk	59	22	that	that	WDT
cord-321607-3r736dnk	59	23	inhibited	inhibit	VBD
cord-321607-3r736dnk	59	24	proteasomal	proteasomal	JJ
cord-321607-3r736dnk	59	25	chymotrypsin	chymotrypsin	NN
cord-321607-3r736dnk	59	26	-	-	HYPH
cord-321607-3r736dnk	59	27	like	like	JJ
cord-321607-3r736dnk	59	28	activity	activity	NN
cord-321607-3r736dnk	59	29	[	[	-LRB-
cord-321607-3r736dnk	59	30	62	62	CD
cord-321607-3r736dnk	59	31	]	]	-RRB-
cord-321607-3r736dnk	59	32	.	.	.
cord-321607-3r736dnk	60	1	Hydroxylation	Hydroxylation	NNP
cord-321607-3r736dnk	60	2	of	of	IN
cord-321607-3r736dnk	60	3	RNase	RNase	NNP
cord-321607-3r736dnk	60	4	-	-	HYPH
cord-321607-3r736dnk	60	5	L	L	NNP
cord-321607-3r736dnk	60	6	was	be	VBD
cord-321607-3r736dnk	60	7	discovered	discover	VBN
cord-321607-3r736dnk	60	8	in	in	IN
cord-321607-3r736dnk	60	9	a	a	DT
cord-321607-3r736dnk	60	10	screen	screen	NN
cord-321607-3r736dnk	60	11	for	for	IN
cord-321607-3r736dnk	60	12	novel	novel	NN
cord-321607-3r736dnk	60	13	substrate	substrate	NN
cord-321607-3r736dnk	60	14	interactors	interactor	NNS
cord-321607-3r736dnk	60	15	for	for	IN
cord-321607-3r736dnk	60	16	the	the	DT
cord-321607-3r736dnk	60	17	asparaginyl	asparaginyl	NNP
cord-321607-3r736dnk	60	18	hydroxylase	hydroxylase	NN
cord-321607-3r736dnk	60	19	factor	factor	NN
cord-321607-3r736dnk	60	20	inhibiting	inhibit	VBG
cord-321607-3r736dnk	60	21	hypoxia	hypoxia	NN
cord-321607-3r736dnk	60	22	-	-	HYPH
cord-321607-3r736dnk	60	23	inducible	inducible	JJ
cord-321607-3r736dnk	60	24	factor	factor	NN
cord-321607-3r736dnk	60	25	(	(	-LRB-
cord-321607-3r736dnk	60	26	HIF	HIF	NNP
cord-321607-3r736dnk	60	27	)	)	-RRB-
cord-321607-3r736dnk	60	28	.	.	.
cord-321607-3r736dnk	61	1	Hydroxylation	Hydroxylation	NNP
cord-321607-3r736dnk	61	2	typically	typically	RB
cord-321607-3r736dnk	61	3	adds	add	VBZ
cord-321607-3r736dnk	61	4	an	an	DT
cord-321607-3r736dnk	61	5	-OH	-oh	NN
cord-321607-3r736dnk	61	6	group	group	NN
cord-321607-3r736dnk	61	7	to	to	IN
cord-321607-3r736dnk	61	8	either	either	CC
cord-321607-3r736dnk	61	9	Pro	Pro	NNP
cord-321607-3r736dnk	61	10	or	or	CC
cord-321607-3r736dnk	61	11	Asn	Asn	NNP
cord-321607-3r736dnk	61	12	residues	residue	NNS
cord-321607-3r736dnk	61	13	and	and	CC
cord-321607-3r736dnk	61	14	has	have	VBZ
cord-321607-3r736dnk	61	15	been	be	VBN
cord-321607-3r736dnk	61	16	shown	show	VBN
cord-321607-3r736dnk	61	17	to	to	TO
cord-321607-3r736dnk	61	18	increase	increase	VB
cord-321607-3r736dnk	61	19	stability	stability	NN
cord-321607-3r736dnk	61	20	,	,	,
cord-321607-3r736dnk	61	21	inhibit	inhibit	VB
cord-321607-3r736dnk	61	22	signaling	signal	VBG
cord-321607-3r736dnk	61	23	,	,	,
cord-321607-3r736dnk	61	24	or	or	CC
cord-321607-3r736dnk	61	25	disrupt	disrupt	VB
cord-321607-3r736dnk	61	26	protein	protein	NN
cord-321607-3r736dnk	61	27	complex	complex	JJ
cord-321607-3r736dnk	61	28	formations	formation	NNS
cord-321607-3r736dnk	61	29	.	.	.
cord-321607-3r736dnk	62	1	The	the	DT
cord-321607-3r736dnk	62	2	hydroxylation	hydroxylation	NN
cord-321607-3r736dnk	62	3	of	of	IN
cord-321607-3r736dnk	62	4	RNase	RNase	NNP
cord-321607-3r736dnk	62	5	-	-	HYPH
cord-321607-3r736dnk	62	6	L	L	NNP
cord-321607-3r736dnk	62	7	occurs	occur	VBZ
cord-321607-3r736dnk	62	8	at	at	IN
cord-321607-3r736dnk	62	9	Asn-196	Asn-196	NNP
cord-321607-3r736dnk	62	10	in	in	IN
cord-321607-3r736dnk	62	11	the	the	DT
cord-321607-3r736dnk	62	12	fifth	fifth	JJ
cord-321607-3r736dnk	62	13	ankyrin	ankyrin	NNP
cord-321607-3r736dnk	62	14	repeat	repeat	NN
cord-321607-3r736dnk	62	15	domain	domain	NN
cord-321607-3r736dnk	62	16	;	;	:
cord-321607-3r736dnk	62	17	however	however	RB
cord-321607-3r736dnk	62	18	,	,	,
cord-321607-3r736dnk	62	19	the	the	DT
cord-321607-3r736dnk	62	20	effect	effect	NN
cord-321607-3r736dnk	62	21	of	of	IN
cord-321607-3r736dnk	62	22	this	this	DT
cord-321607-3r736dnk	62	23	modification	modification	NN
cord-321607-3r736dnk	62	24	is	be	VBZ
cord-321607-3r736dnk	62	25	unknown	unknown	JJ
cord-321607-3r736dnk	62	26	[	[	-LRB-
cord-321607-3r736dnk	62	27	63	63	CD
cord-321607-3r736dnk	62	28	]	]	-RRB-
cord-321607-3r736dnk	62	29	.	.	.
cord-321607-3r736dnk	63	1	RNase	RNase	NNP
cord-321607-3r736dnk	63	2	-	-	HYPH
cord-321607-3r736dnk	63	3	L	L	NNP
cord-321607-3r736dnk	63	4	can	can	MD
cord-321607-3r736dnk	63	5	also	also	RB
cord-321607-3r736dnk	63	6	be	be	VB
cord-321607-3r736dnk	63	7	regulated	regulate	VBN
cord-321607-3r736dnk	63	8	through	through	IN
cord-321607-3r736dnk	63	9	several	several	JJ
cord-321607-3r736dnk	63	10	other	other	JJ
cord-321607-3r736dnk	63	11	protein	protein	NN
cord-321607-3r736dnk	63	12	-	-	HYPH
cord-321607-3r736dnk	63	13	protein	protein	NN
cord-321607-3r736dnk	63	14	interactions	interaction	NNS
cord-321607-3r736dnk	63	15	.	.	.
cord-321607-3r736dnk	64	1	The	the	DT
cord-321607-3r736dnk	64	2	best	well	RBS
cord-321607-3r736dnk	64	3	characterized	characterize	VBN
cord-321607-3r736dnk	64	4	RNase	rnase	NN
cord-321607-3r736dnk	64	5	-	-	HYPH
cord-321607-3r736dnk	64	6	L	l	NN
cord-321607-3r736dnk	64	7	binding	binding	NN
cord-321607-3r736dnk	64	8	protein	protein	NN
cord-321607-3r736dnk	64	9	is	be	VBZ
cord-321607-3r736dnk	64	10	the	the	DT
cord-321607-3r736dnk	64	11	RNase	RNase	NNP
cord-321607-3r736dnk	64	12	-	-	HYPH
cord-321607-3r736dnk	64	13	L	l	NN
cord-321607-3r736dnk	64	14	inhibitor	inhibitor	NN
cord-321607-3r736dnk	64	15	(	(	-LRB-
cord-321607-3r736dnk	64	16	RLI	RLI	NNP
cord-321607-3r736dnk	64	17	)	)	-RRB-
cord-321607-3r736dnk	64	18	.	.	.
cord-321607-3r736dnk	65	1	RLI	RLI	NNP
cord-321607-3r736dnk	65	2	inhibits	inhibit	VBZ
cord-321607-3r736dnk	65	3	RNase	RNase	NNP
cord-321607-3r736dnk	65	4	-	-	HYPH
cord-321607-3r736dnk	65	5	L	l	NN
cord-321607-3r736dnk	65	6	as	as	IN
cord-321607-3r736dnk	65	7	part	part	NN
cord-321607-3r736dnk	65	8	of	of	IN
cord-321607-3r736dnk	65	9	a	a	DT
cord-321607-3r736dnk	65	10	complex	complex	JJ
cord-321607-3r736dnk	65	11	containing	contain	VBG
cord-321607-3r736dnk	65	12	RLI	RLI	NNP
cord-321607-3r736dnk	65	13	,	,	,
cord-321607-3r736dnk	65	14	RNase	RNase	NNP
cord-321607-3r736dnk	65	15	-	-	HYPH
cord-321607-3r736dnk	65	16	L	L	NNP
cord-321607-3r736dnk	65	17	,	,	,
cord-321607-3r736dnk	65	18	and	and	CC
cord-321607-3r736dnk	65	19	the	the	DT
cord-321607-3r736dnk	65	20	translation	translation	NN
cord-321607-3r736dnk	65	21	termination	termination	NN
cord-321607-3r736dnk	65	22	-	-	HYPH
cord-321607-3r736dnk	65	23	associated	associate	VBN
cord-321607-3r736dnk	65	24	GTPase	GTPase	NNP
cord-321607-3r736dnk	65	25	,	,	,
cord-321607-3r736dnk	65	26	eRF3	eRF3	NNP
cord-321607-3r736dnk	65	27	[	[	-LRB-
cord-321607-3r736dnk	65	28	64	64	CD
cord-321607-3r736dnk	65	29	]	]	-RRB-
cord-321607-3r736dnk	65	30	.	.	.
cord-321607-3r736dnk	66	1	RLI	RLI	NNP
cord-321607-3r736dnk	66	2	,	,	,
cord-321607-3r736dnk	66	3	also	also	RB
cord-321607-3r736dnk	66	4	known	know	VBN
cord-321607-3r736dnk	66	5	as	as	IN
cord-321607-3r736dnk	66	6	ABCE1	abce1	NN
cord-321607-3r736dnk	66	7	,	,	,
cord-321607-3r736dnk	66	8	is	be	VBZ
cord-321607-3r736dnk	66	9	a	a	DT
cord-321607-3r736dnk	66	10	member	member	NN
cord-321607-3r736dnk	66	11	of	of	IN
cord-321607-3r736dnk	66	12	the	the	DT
cord-321607-3r736dnk	66	13	ATP	ATP	NNP
cord-321607-3r736dnk	66	14	binding	bind	VBG
cord-321607-3r736dnk	66	15	cassette	cassette	NN
cord-321607-3r736dnk	66	16	superfamily	superfamily	NN
cord-321607-3r736dnk	66	17	and	and	CC
cord-321607-3r736dnk	66	18	,	,	,
cord-321607-3r736dnk	66	19	aside	aside	RB
cord-321607-3r736dnk	66	20	from	from	IN
cord-321607-3r736dnk	66	21	its	-PRON-	PRP$
cord-321607-3r736dnk	66	22	role	role	NN
cord-321607-3r736dnk	66	23	as	as	IN
cord-321607-3r736dnk	66	24	an	an	DT
cord-321607-3r736dnk	66	25	RNase	RNase	NNP
cord-321607-3r736dnk	66	26	-	-	HYPH
cord-321607-3r736dnk	66	27	L	l	NN
cord-321607-3r736dnk	66	28	inhibitor	inhibitor	NN
cord-321607-3r736dnk	66	29	,	,	,
cord-321607-3r736dnk	66	30	is	be	VBZ
cord-321607-3r736dnk	66	31	believed	believe	VBN
cord-321607-3r736dnk	66	32	to	to	TO
cord-321607-3r736dnk	66	33	be	be	VB
cord-321607-3r736dnk	66	34	involved	involve	VBN
cord-321607-3r736dnk	66	35	in	in	IN
cord-321607-3r736dnk	66	36	translation	translation	NN
cord-321607-3r736dnk	66	37	termination	termination	NN
cord-321607-3r736dnk	66	38	and	and	CC
cord-321607-3r736dnk	66	39	ribosome	ribosome	NN
cord-321607-3r736dnk	66	40	recycling	recycling	NN
cord-321607-3r736dnk	66	41	[	[	-LRB-
cord-321607-3r736dnk	66	42	65	65	CD
cord-321607-3r736dnk	66	43	]	]	-RRB-
cord-321607-3r736dnk	66	44	[	[	-LRB-
cord-321607-3r736dnk	66	45	66	66	CD
cord-321607-3r736dnk	66	46	]	]	-RRB-
cord-321607-3r736dnk	67	1	[	[	-LRB-
cord-321607-3r736dnk	67	2	67	67	CD
cord-321607-3r736dnk	67	3	]	]	-RRB-
cord-321607-3r736dnk	67	4	.	.	.
cord-321607-3r736dnk	68	1	The	the	DT
cord-321607-3r736dnk	68	2	mechanism	mechanism	NN
cord-321607-3r736dnk	68	3	for	for	IN
cord-321607-3r736dnk	68	4	RNase	RNase	NNP
cord-321607-3r736dnk	68	5	-	-	HYPH
cord-321607-3r736dnk	68	6	L	l	NN
cord-321607-3r736dnk	68	7	inhibition	inhibition	NN
cord-321607-3r736dnk	68	8	is	be	VBZ
cord-321607-3r736dnk	68	9	believed	believe	VBN
cord-321607-3r736dnk	68	10	to	to	TO
cord-321607-3r736dnk	68	11	be	be	VB
cord-321607-3r736dnk	68	12	through	through	IN
cord-321607-3r736dnk	68	13	direct	direct	JJ
cord-321607-3r736dnk	68	14	binding	binding	NN
cord-321607-3r736dnk	68	15	with	with	IN
cord-321607-3r736dnk	68	16	RLI	RLI	NNP
cord-321607-3r736dnk	68	17	,	,	,
cord-321607-3r736dnk	68	18	as	as	IN
cord-321607-3r736dnk	68	19	RLI	RLI	NNP
cord-321607-3r736dnk	68	20	is	be	VBZ
cord-321607-3r736dnk	68	21	not	not	RB
cord-321607-3r736dnk	68	22	known	know	VBN
cord-321607-3r736dnk	68	23	to	to	TO
cord-321607-3r736dnk	68	24	bind	bind	VB
cord-321607-3r736dnk	68	25	competitively	competitively	RB
cord-321607-3r736dnk	68	26	with	with	IN
cord-321607-3r736dnk	68	27	2	2	CD
cord-321607-3r736dnk	68	28	-	-	SYM
cord-321607-3r736dnk	68	29	5A.	5a.	CD
cord-321607-3r736dnk	68	30	Regardless	regardless	RB
cord-321607-3r736dnk	68	31	of	of	IN
cord-321607-3r736dnk	68	32	the	the	DT
cord-321607-3r736dnk	68	33	mechanism	mechanism	NN
cord-321607-3r736dnk	68	34	,	,	,
cord-321607-3r736dnk	68	35	however	however	RB
cord-321607-3r736dnk	68	36	,	,	,
cord-321607-3r736dnk	68	37	overexpression	overexpression	NN
cord-321607-3r736dnk	68	38	or	or	CC
cord-321607-3r736dnk	68	39	knockdown	knockdown	NN
cord-321607-3r736dnk	68	40	of	of	IN
cord-321607-3r736dnk	68	41	RLI	RLI	NNP
cord-321607-3r736dnk	68	42	has	have	VBZ
cord-321607-3r736dnk	68	43	inhibitory	inhibitory	JJ
cord-321607-3r736dnk	68	44	or	or	CC
cord-321607-3r736dnk	68	45	promoting	promote	VBG
cord-321607-3r736dnk	68	46	effects	effect	NNS
cord-321607-3r736dnk	68	47	on	on	IN
cord-321607-3r736dnk	68	48	the	the	DT
cord-321607-3r736dnk	68	49	binding	binding	NN
cord-321607-3r736dnk	68	50	of	of	IN
cord-321607-3r736dnk	68	51	RNase	RNase	NNP
cord-321607-3r736dnk	68	52	-	-	HYPH
cord-321607-3r736dnk	68	53	L	l	NN
cord-321607-3r736dnk	68	54	to	to	IN
cord-321607-3r736dnk	68	55	2	2	CD
cord-321607-3r736dnk	68	56	-	-	HYPH
cord-321607-3r736dnk	68	57	5A	5a	CD
cord-321607-3r736dnk	68	58	,	,	,
cord-321607-3r736dnk	68	59	rRNA	rrna	NN
cord-321607-3r736dnk	68	60	cleavage	cleavage	NN
cord-321607-3r736dnk	68	61	,	,	,
cord-321607-3r736dnk	68	62	destabilization	destabilization	NN
cord-321607-3r736dnk	68	63	of	of	IN
cord-321607-3r736dnk	68	64	mitochondrial	mitochondrial	NN
cord-321607-3r736dnk	68	65	mRNA	mrna	NN
cord-321607-3r736dnk	68	66	,	,	,
cord-321607-3r736dnk	68	67	antiviral	antiviral	JJ
cord-321607-3r736dnk	68	68	activity	activity	NN
cord-321607-3r736dnk	68	69	,	,	,
cord-321607-3r736dnk	68	70	and	and	CC
cord-321607-3r736dnk	68	71	antitumor	antitumor	JJ
cord-321607-3r736dnk	68	72	activity	activity	NN
cord-321607-3r736dnk	68	73	[	[	-LRB-
cord-321607-3r736dnk	68	74	68	68	CD
cord-321607-3r736dnk	68	75	]	]	-RRB-
cord-321607-3r736dnk	68	76	[	[	-LRB-
cord-321607-3r736dnk	68	77	69	69	CD
cord-321607-3r736dnk	68	78	]	]	-RRB-
cord-321607-3r736dnk	68	79	[	[	-LRB-
cord-321607-3r736dnk	68	80	70	70	CD
cord-321607-3r736dnk	68	81	]	]	-RRB-
cord-321607-3r736dnk	68	82	[	[	-LRB-
cord-321607-3r736dnk	68	83	71	71	CD
cord-321607-3r736dnk	68	84	]	]	-RRB-
cord-321607-3r736dnk	68	85	.	.	.
cord-321607-3r736dnk	69	1	Three	three	CD
cord-321607-3r736dnk	69	2	other	other	JJ
cord-321607-3r736dnk	69	3	interacting	interact	VBG
cord-321607-3r736dnk	69	4	proteins	protein	NNS
cord-321607-3r736dnk	69	5	are	be	VBP
cord-321607-3r736dnk	69	6	believed	believe	VBN
cord-321607-3r736dnk	69	7	to	to	TO
cord-321607-3r736dnk	69	8	possibly	possibly	RB
cord-321607-3r736dnk	69	9	help	help	VB
cord-321607-3r736dnk	69	10	target	target	VB
cord-321607-3r736dnk	69	11	RNase	RNase	NNP
cord-321607-3r736dnk	69	12	-	-	HYPH
cord-321607-3r736dnk	69	13	L	l	NN
cord-321607-3r736dnk	69	14	to	to	IN
cord-321607-3r736dnk	69	15	ssRNA	ssrna	NN
cord-321607-3r736dnk	69	16	substrates	substrate	NNS
cord-321607-3r736dnk	69	17	:	:	:
cord-321607-3r736dnk	69	18	the	the	DT
cord-321607-3r736dnk	69	19	eukaryotic	eukaryotic	JJ
cord-321607-3r736dnk	69	20	translation	translation	NN
cord-321607-3r736dnk	69	21	termination	termination	NN
cord-321607-3r736dnk	69	22	release	release	NN
cord-321607-3r736dnk	69	23	factor	factor	NN
cord-321607-3r736dnk	69	24	eRF3	eRF3	NNP
cord-321607-3r736dnk	69	25	,	,	,
cord-321607-3r736dnk	69	26	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	69	27	translation	translation	NN
cord-321607-3r736dnk	69	28	initiation	initiation	NN
cord-321607-3r736dnk	69	29	factor	factor	NN
cord-321607-3r736dnk	69	30	(	(	-LRB-
cord-321607-3r736dnk	69	31	IF2mt	IF2mt	NNP
cord-321607-3r736dnk	69	32	)	)	-RRB-
cord-321607-3r736dnk	69	33	,	,	,
cord-321607-3r736dnk	69	34	and	and	CC
cord-321607-3r736dnk	69	35	tristetraprolin	tristetraprolin	NNP
cord-321607-3r736dnk	69	36	(	(	-LRB-
cord-321607-3r736dnk	69	37	TTP	TTP	NNP
cord-321607-3r736dnk	69	38	)	)	-RRB-
cord-321607-3r736dnk	69	39	.	.	.
cord-321607-3r736dnk	70	1	eRF3	eRF3	NNP
cord-321607-3r736dnk	70	2	was	be	VBD
cord-321607-3r736dnk	70	3	discovered	discover	VBN
cord-321607-3r736dnk	70	4	as	as	IN
cord-321607-3r736dnk	70	5	an	an	DT
cord-321607-3r736dnk	70	6	RNase	RNase	NNP
cord-321607-3r736dnk	70	7	-	-	HYPH
cord-321607-3r736dnk	70	8	L	l	NN
cord-321607-3r736dnk	70	9	interacting	interact	VBG
cord-321607-3r736dnk	70	10	partner	partner	NN
cord-321607-3r736dnk	70	11	in	in	IN
cord-321607-3r736dnk	70	12	1993	1993	CD
cord-321607-3r736dnk	70	13	but	but	CC
cord-321607-3r736dnk	70	14	was	be	VBD
cord-321607-3r736dnk	70	15	originally	originally	RB
cord-321607-3r736dnk	70	16	termed	term	VBN
cord-321607-3r736dnk	70	17	RNABP	RNABP	NNP
cord-321607-3r736dnk	71	1	(	(	-LRB-
cord-321607-3r736dnk	71	2	RNA	RNA	NNP
cord-321607-3r736dnk	71	3	binding	bind	VBG
cord-321607-3r736dnk	71	4	protein	protein	NN
cord-321607-3r736dnk	71	5	)	)	-RRB-
cord-321607-3r736dnk	71	6	until	until	IN
cord-321607-3r736dnk	71	7	its	-PRON-	PRP$
cord-321607-3r736dnk	71	8	proper	proper	JJ
cord-321607-3r736dnk	71	9	identification	identification	NN
cord-321607-3r736dnk	71	10	in	in	IN
cord-321607-3r736dnk	71	11	2005	2005	CD
cord-321607-3r736dnk	71	12	by	by	IN
cord-321607-3r736dnk	71	13	Le	Le	NNP
cord-321607-3r736dnk	71	14	Roy	Roy	NNP
cord-321607-3r736dnk	71	15	et	et	NNP
cord-321607-3r736dnk	71	16	al	al	NNP
cord-321607-3r736dnk	71	17	.	.	.
cord-321607-3r736dnk	72	1	[	[	-LRB-
cord-321607-3r736dnk	72	2	72	72	CD
cord-321607-3r736dnk	72	3	]	]	-RRB-
cord-321607-3r736dnk	72	4	.	.	.
cord-321607-3r736dnk	73	1	It	-PRON-	PRP
cord-321607-3r736dnk	73	2	binds	bind	VBZ
cord-321607-3r736dnk	73	3	to	to	IN
cord-321607-3r736dnk	73	4	RNase	RNase	NNP
cord-321607-3r736dnk	73	5	-	-	HYPH
cord-321607-3r736dnk	73	6	L	l	NN
cord-321607-3r736dnk	73	7	as	as	IN
cord-321607-3r736dnk	73	8	part	part	NN
cord-321607-3r736dnk	73	9	of	of	IN
cord-321607-3r736dnk	73	10	a	a	DT
cord-321607-3r736dnk	73	11	complex	complex	NN
cord-321607-3r736dnk	73	12	and	and	CC
cord-321607-3r736dnk	73	13	is	be	VBZ
cord-321607-3r736dnk	73	14	believed	believe	VBN
cord-321607-3r736dnk	73	15	to	to	TO
cord-321607-3r736dnk	73	16	help	help	VB
cord-321607-3r736dnk	73	17	facilitate	facilitate	VB
cord-321607-3r736dnk	73	18	its	-PRON-	PRP$
cord-321607-3r736dnk	73	19	activity	activity	NN
cord-321607-3r736dnk	73	20	,	,	,
cord-321607-3r736dnk	73	21	since	since	IN
cord-321607-3r736dnk	73	22	a	a	DT
cord-321607-3r736dnk	73	23	presumed	presume	VBN
cord-321607-3r736dnk	73	24	eRF3-inhibitory	erf3-inhibitory	CD
cord-321607-3r736dnk	73	25	antibody	antibody	NN
cord-321607-3r736dnk	73	26	,	,	,
cord-321607-3r736dnk	73	27	mAb3	mAb3	NNPS
cord-321607-3r736dnk	73	28	,	,	,
cord-321607-3r736dnk	73	29	blocks	block	VBZ
cord-321607-3r736dnk	73	30	RNase	RNase	NNP
cord-321607-3r736dnk	73	31	-	-	HYPH
cord-321607-3r736dnk	73	32	L	l	NN
cord-321607-3r736dnk	73	33	-	-	HYPH
cord-321607-3r736dnk	73	34	mediated	mediate	VBN
cord-321607-3r736dnk	73	35	rRNA	rrna	NN
cord-321607-3r736dnk	73	36	cleavage	cleavage	NN
cord-321607-3r736dnk	73	37	and	and	CC
cord-321607-3r736dnk	73	38	antiviral	antiviral	JJ
cord-321607-3r736dnk	73	39	activity	activity	NN
cord-321607-3r736dnk	73	40	[	[	-LRB-
cord-321607-3r736dnk	73	41	73	73	CD
cord-321607-3r736dnk	73	42	]	]	-RRB-
cord-321607-3r736dnk	73	43	.	.	.
cord-321607-3r736dnk	74	1	Although	although	IN
cord-321607-3r736dnk	74	2	eRF3	eRF3	NNP
cord-321607-3r736dnk	74	3	does	do	VBZ
cord-321607-3r736dnk	74	4	not	not	RB
cord-321607-3r736dnk	74	5	bind	bind	VB
cord-321607-3r736dnk	74	6	2	2	CD
cord-321607-3r736dnk	74	7	-	-	HYPH
cord-321607-3r736dnk	74	8	5A	5a	NN
cord-321607-3r736dnk	74	9	directly	directly	RB
cord-321607-3r736dnk	74	10	,	,	,
cord-321607-3r736dnk	74	11	the	the	DT
cord-321607-3r736dnk	74	12	presence	presence	NN
cord-321607-3r736dnk	74	13	of	of	IN
cord-321607-3r736dnk	74	14	2	2	CD
cord-321607-3r736dnk	74	15	-	-	HYPH
cord-321607-3r736dnk	74	16	5A	5a	NN
cord-321607-3r736dnk	74	17	enhances	enhance	VBZ
cord-321607-3r736dnk	74	18	the	the	DT
cord-321607-3r736dnk	74	19	eRF3-RNase	eRF3-RNase	NNP
cord-321607-3r736dnk	74	20	-	-	HYPH
cord-321607-3r736dnk	74	21	L	l	NN
cord-321607-3r736dnk	74	22	interaction	interaction	NN
cord-321607-3r736dnk	74	23	,	,	,
cord-321607-3r736dnk	74	24	again	again	RB
cord-321607-3r736dnk	74	25	suggesting	suggest	VBG
cord-321607-3r736dnk	74	26	that	that	IN
cord-321607-3r736dnk	74	27	eRF3	eRF3	NNP
cord-321607-3r736dnk	74	28	is	be	VBZ
cord-321607-3r736dnk	74	29	important	important	JJ
cord-321607-3r736dnk	74	30	to	to	IN
cord-321607-3r736dnk	74	31	RNase	RNase	NNP
cord-321607-3r736dnk	74	32	-	-	HYPH
cord-321607-3r736dnk	74	33	L	l	NN
cord-321607-3r736dnk	74	34	function	function	NN
cord-321607-3r736dnk	74	35	.	.	.
cord-321607-3r736dnk	75	1	eRF3	eRF3	NNP
cord-321607-3r736dnk	75	2	,	,	,
cord-321607-3r736dnk	75	3	in	in	IN
cord-321607-3r736dnk	75	4	conjunction	conjunction	NN
cord-321607-3r736dnk	75	5	with	with	IN
cord-321607-3r736dnk	75	6	eRF1	eRF1	NNP
cord-321607-3r736dnk	75	7	,	,	,
cord-321607-3r736dnk	75	8	mediates	mediate	VBZ
cord-321607-3r736dnk	75	9	the	the	DT
cord-321607-3r736dnk	75	10	release	release	NN
cord-321607-3r736dnk	75	11	of	of	IN
cord-321607-3r736dnk	75	12	the	the	DT
cord-321607-3r736dnk	75	13	polypeptide	polypeptide	NN
cord-321607-3r736dnk	75	14	chain	chain	NN
cord-321607-3r736dnk	75	15	from	from	IN
cord-321607-3r736dnk	75	16	the	the	DT
cord-321607-3r736dnk	75	17	ribosome	ribosome	NN
cord-321607-3r736dnk	75	18	during	during	IN
cord-321607-3r736dnk	75	19	translation	translation	NN
cord-321607-3r736dnk	75	20	termination	termination	NN
cord-321607-3r736dnk	75	21	.	.	.
cord-321607-3r736dnk	76	1	It	-PRON-	PRP
cord-321607-3r736dnk	76	2	also	also	RB
cord-321607-3r736dnk	76	3	interacts	interact	VBZ
cord-321607-3r736dnk	76	4	with	with	IN
cord-321607-3r736dnk	76	5	RLI	RLI	NNP
cord-321607-3r736dnk	76	6	and	and	CC
cord-321607-3r736dnk	76	7	the	the	DT
cord-321607-3r736dnk	76	8	poly(A)-binding	poly(A)-binding	NNP
cord-321607-3r736dnk	76	9	protein	protein	NN
cord-321607-3r736dnk	76	10	(	(	-LRB-
cord-321607-3r736dnk	76	11	PABP	PABP	NNP
cord-321607-3r736dnk	76	12	)	)	-RRB-
cord-321607-3r736dnk	76	13	,	,	,
cord-321607-3r736dnk	76	14	which	which	WDT
cord-321607-3r736dnk	76	15	facilitates	facilitate	VBZ
cord-321607-3r736dnk	76	16	ribosome	ribosome	NN
cord-321607-3r736dnk	76	17	recycling	recycling	NN
cord-321607-3r736dnk	76	18	by	by	IN
cord-321607-3r736dnk	76	19	reinitiating	reinitiate	VBG
cord-321607-3r736dnk	76	20	translation	translation	NN
cord-321607-3r736dnk	76	21	after	after	IN
cord-321607-3r736dnk	76	22	termination	termination	NN
cord-321607-3r736dnk	76	23	[	[	-LRB-
cord-321607-3r736dnk	76	24	74	74	CD
cord-321607-3r736dnk	76	25	]	]	-RRB-
cord-321607-3r736dnk	76	26	.	.	.
cord-321607-3r736dnk	77	1	RNase	RNase	NNP
cord-321607-3r736dnk	77	2	-	-	HYPH
cord-321607-3r736dnk	77	3	L	l	NN
cord-321607-3r736dnk	77	4	localization	localization	NN
cord-321607-3r736dnk	77	5	with	with	IN
cord-321607-3r736dnk	77	6	this	this	DT
cord-321607-3r736dnk	77	7	translation	translation	NN
cord-321607-3r736dnk	77	8	termination	termination	NN
cord-321607-3r736dnk	77	9	complex	complex	NN
cord-321607-3r736dnk	77	10	places	place	VBZ
cord-321607-3r736dnk	77	11	it	-PRON-	PRP
cord-321607-3r736dnk	77	12	in	in	IN
cord-321607-3r736dnk	77	13	close	close	JJ
cord-321607-3r736dnk	77	14	proximity	proximity	NN
cord-321607-3r736dnk	77	15	to	to	IN
cord-321607-3r736dnk	77	16	potential	potential	JJ
cord-321607-3r736dnk	77	17	mRNA	mRNA	NNP
cord-321607-3r736dnk	77	18	targets	target	NNS
cord-321607-3r736dnk	77	19	as	as	IN
cord-321607-3r736dnk	77	20	they	-PRON-	PRP
cord-321607-3r736dnk	77	21	are	be	VBP
cord-321607-3r736dnk	77	22	translated	translate	VBN
cord-321607-3r736dnk	77	23	on	on	IN
cord-321607-3r736dnk	77	24	polysomes	polysome	NNS
cord-321607-3r736dnk	77	25	.	.	.
cord-321607-3r736dnk	78	1	Actively	actively	RB
cord-321607-3r736dnk	78	2	translating	translate	VBG
cord-321607-3r736dnk	78	3	RNAs	rna	NNS
cord-321607-3r736dnk	78	4	adopt	adopt	VBP
cord-321607-3r736dnk	78	5	a	a	DT
cord-321607-3r736dnk	78	6	closed	closed	JJ
cord-321607-3r736dnk	78	7	-	-	HYPH
cord-321607-3r736dnk	78	8	loop	loop	NN
cord-321607-3r736dnk	78	9	conformation	conformation	NN
cord-321607-3r736dnk	78	10	in	in	IN
cord-321607-3r736dnk	78	11	which	which	WDT
cord-321607-3r736dnk	78	12	the	the	DT
cord-321607-3r736dnk	78	13	3	3	CD
cord-321607-3r736dnk	78	14	1	1	CD
cord-321607-3r736dnk	78	15	UTR	UTR	NNP
cord-321607-3r736dnk	78	16	forms	form	VBZ
cord-321607-3r736dnk	78	17	an	an	DT
cord-321607-3r736dnk	78	18	exposed	expose	VBN
cord-321607-3r736dnk	78	19	loop	loop	NN
cord-321607-3r736dnk	78	20	that	that	WDT
cord-321607-3r736dnk	78	21	may	may	MD
cord-321607-3r736dnk	78	22	be	be	VB
cord-321607-3r736dnk	78	23	accessible	accessible	JJ
cord-321607-3r736dnk	78	24	to	to	IN
cord-321607-3r736dnk	78	25	regulatory	regulatory	JJ
cord-321607-3r736dnk	78	26	factors	factor	NNS
cord-321607-3r736dnk	78	27	.	.	.
cord-321607-3r736dnk	79	1	When	when	WRB
cord-321607-3r736dnk	79	2	active	active	JJ
cord-321607-3r736dnk	79	3	,	,	,
cord-321607-3r736dnk	79	4	RNase	RNase	NNP
cord-321607-3r736dnk	79	5	-	-	HYPH
cord-321607-3r736dnk	79	6	L	L	NNP
cord-321607-3r736dnk	79	7	can	can	MD
cord-321607-3r736dnk	79	8	outcompete	outcompete	VB
cord-321607-3r736dnk	79	9	PABP	PABP	NNP
cord-321607-3r736dnk	79	10	for	for	IN
cord-321607-3r736dnk	79	11	eRF3	eRF3	NNP
cord-321607-3r736dnk	79	12	interaction	interaction	NN
cord-321607-3r736dnk	79	13	in	in	IN
cord-321607-3r736dnk	79	14	the	the	DT
cord-321607-3r736dnk	79	15	termination	termination	NN
cord-321607-3r736dnk	79	16	complex	complex	NN
cord-321607-3r736dnk	79	17	,	,	,
cord-321607-3r736dnk	79	18	displacing	displace	VBG
cord-321607-3r736dnk	79	19	it	-PRON-	PRP
cord-321607-3r736dnk	79	20	and	and	CC
cord-321607-3r736dnk	79	21	providing	provide	VBG
cord-321607-3r736dnk	79	22	RNase	RNase	NNP
cord-321607-3r736dnk	79	23	-	-	HYPH
cord-321607-3r736dnk	79	24	L	l	NN
cord-321607-3r736dnk	79	25	with	with	IN
cord-321607-3r736dnk	79	26	access	access	NN
cord-321607-3r736dnk	79	27	to	to	IN
cord-321607-3r736dnk	79	28	mRNA	mrna	NN
cord-321607-3r736dnk	79	29	substrates	substrate	NNS
cord-321607-3r736dnk	79	30	[	[	-LRB-
cord-321607-3r736dnk	79	31	25	25	CD
cord-321607-3r736dnk	79	32	,	,	,
cord-321607-3r736dnk	79	33	72	72	CD
cord-321607-3r736dnk	79	34	]	]	-RRB-
cord-321607-3r736dnk	79	35	.	.	.
cord-321607-3r736dnk	80	1	One	one	CD
cord-321607-3r736dnk	80	2	caveat	caveat	NN
cord-321607-3r736dnk	80	3	to	to	IN
cord-321607-3r736dnk	80	4	this	this	DT
cord-321607-3r736dnk	80	5	targeting	targeting	NN
cord-321607-3r736dnk	80	6	model	model	NN
cord-321607-3r736dnk	80	7	is	be	VBZ
cord-321607-3r736dnk	80	8	that	that	IN
cord-321607-3r736dnk	80	9	while	while	IN
cord-321607-3r736dnk	80	10	ribosomes	ribosome	NNS
cord-321607-3r736dnk	80	11	translate	translate	VBP
cord-321607-3r736dnk	80	12	all	all	DT
cord-321607-3r736dnk	80	13	mRNAs	mrnas	CD
cord-321607-3r736dnk	80	14	,	,	,
cord-321607-3r736dnk	80	15	RNase	RNase	NNP
cord-321607-3r736dnk	80	16	-	-	HYPH
cord-321607-3r736dnk	80	17	L	L	NNP
cord-321607-3r736dnk	80	18	is	be	VBZ
cord-321607-3r736dnk	80	19	selective	selective	JJ
cord-321607-3r736dnk	80	20	,	,	,
cord-321607-3r736dnk	80	21	indicating	indicate	VBG
cord-321607-3r736dnk	80	22	that	that	IN
cord-321607-3r736dnk	80	23	other	other	JJ
cord-321607-3r736dnk	80	24	factors	factor	NNS
cord-321607-3r736dnk	80	25	are	be	VBP
cord-321607-3r736dnk	80	26	needed	need	VBN
cord-321607-3r736dnk	80	27	for	for	IN
cord-321607-3r736dnk	80	28	specific	specific	JJ
cord-321607-3r736dnk	80	29	targeting	targeting	NN
cord-321607-3r736dnk	80	30	.	.	.
cord-321607-3r736dnk	81	1	Similar	similar	JJ
cord-321607-3r736dnk	81	2	to	to	IN
cord-321607-3r736dnk	81	3	the	the	DT
cord-321607-3r736dnk	81	4	accessibility	accessibility	NN
cord-321607-3r736dnk	81	5	that	that	WDT
cord-321607-3r736dnk	81	6	eRF3	eRF3	NNP
cord-321607-3r736dnk	81	7	may	may	MD
cord-321607-3r736dnk	81	8	provide	provide	VB
cord-321607-3r736dnk	81	9	RNase	RNase	NNP
cord-321607-3r736dnk	81	10	-	-	HYPH
cord-321607-3r736dnk	81	11	L	l	NN
cord-321607-3r736dnk	81	12	to	to	IN
cord-321607-3r736dnk	81	13	its	-PRON-	PRP$
cord-321607-3r736dnk	81	14	targets	target	NNS
cord-321607-3r736dnk	81	15	,	,	,
cord-321607-3r736dnk	81	16	another	another	DT
cord-321607-3r736dnk	81	17	binding	bind	VBG
cord-321607-3r736dnk	81	18	partner	partner	NN
cord-321607-3r736dnk	81	19	may	may	MD
cord-321607-3r736dnk	81	20	serve	serve	VB
cord-321607-3r736dnk	81	21	the	the	DT
cord-321607-3r736dnk	81	22	same	same	JJ
cord-321607-3r736dnk	81	23	function	function	NN
cord-321607-3r736dnk	81	24	in	in	IN
cord-321607-3r736dnk	81	25	the	the	DT
cord-321607-3r736dnk	81	26	mitochondrion	mitochondrion	NN
cord-321607-3r736dnk	81	27	.	.	.
cord-321607-3r736dnk	82	1	Although	although	IN
cord-321607-3r736dnk	82	2	RNase	RNase	NNP
cord-321607-3r736dnk	82	3	-	-	HYPH
cord-321607-3r736dnk	82	4	L	L	NNP
cord-321607-3r736dnk	82	5	is	be	VBZ
cord-321607-3r736dnk	82	6	generally	generally	RB
cord-321607-3r736dnk	82	7	considered	consider	VBN
cord-321607-3r736dnk	82	8	to	to	TO
cord-321607-3r736dnk	82	9	be	be	VB
cord-321607-3r736dnk	82	10	cytosolic	cytosolic	JJ
cord-321607-3r736dnk	82	11	,	,	,
cord-321607-3r736dnk	82	12	it	-PRON-	PRP
cord-321607-3r736dnk	82	13	is	be	VBZ
cord-321607-3r736dnk	82	14	also	also	RB
cord-321607-3r736dnk	82	15	found	find	VBN
cord-321607-3r736dnk	82	16	in	in	IN
cord-321607-3r736dnk	82	17	the	the	DT
cord-321607-3r736dnk	82	18	nucleus	nucleus	NN
cord-321607-3r736dnk	82	19	and	and	CC
cord-321607-3r736dnk	82	20	mitochondria	mitochondrion	NNS
cord-321607-3r736dnk	82	21	,	,	,
cord-321607-3r736dnk	82	22	where	where	WRB
cord-321607-3r736dnk	82	23	it	-PRON-	PRP
cord-321607-3r736dnk	82	24	has	have	VBZ
cord-321607-3r736dnk	82	25	been	be	VBN
cord-321607-3r736dnk	82	26	shown	show	VBN
cord-321607-3r736dnk	82	27	to	to	TO
cord-321607-3r736dnk	82	28	downregulate	downregulate	VB
cord-321607-3r736dnk	82	29	the	the	DT
cord-321607-3r736dnk	82	30	expression	expression	NN
cord-321607-3r736dnk	82	31	of	of	IN
cord-321607-3r736dnk	82	32	several	several	JJ
cord-321607-3r736dnk	82	33	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	82	34	RNAs	rna	NNS
cord-321607-3r736dnk	82	35	(	(	-LRB-
cord-321607-3r736dnk	82	36	mtRNA	mtRNA	NNP
cord-321607-3r736dnk	82	37	)	)	-RRB-
cord-321607-3r736dnk	82	38	,	,	,
cord-321607-3r736dnk	82	39	such	such	JJ
cord-321607-3r736dnk	82	40	as	as	IN
cord-321607-3r736dnk	82	41	cytochrome	cytochrome	NN
cord-321607-3r736dnk	82	42	b	b	NN
cord-321607-3r736dnk	82	43	,	,	,
cord-321607-3r736dnk	82	44	ATPase6	ATPase6	NNP
cord-321607-3r736dnk	82	45	,	,	,
cord-321607-3r736dnk	82	46	and	and	CC
cord-321607-3r736dnk	82	47	cytochrome	cytochrome	NN
cord-321607-3r736dnk	82	48	oxidase	oxidase	NN
cord-321607-3r736dnk	82	49	subunit	subunit	NN
cord-321607-3r736dnk	82	50	II	II	NNP
cord-321607-3r736dnk	82	51	[	[	-LRB-
cord-321607-3r736dnk	82	52	68	68	CD
cord-321607-3r736dnk	82	53	,	,	,
cord-321607-3r736dnk	82	54	75	75	CD
cord-321607-3r736dnk	82	55	,	,	,
cord-321607-3r736dnk	82	56	76	76	CD
cord-321607-3r736dnk	82	57	]	]	-RRB-
cord-321607-3r736dnk	82	58	.	.	.
cord-321607-3r736dnk	83	1	In	in	IN
cord-321607-3r736dnk	83	2	support	support	NN
cord-321607-3r736dnk	83	3	of	of	IN
cord-321607-3r736dnk	83	4	a	a	DT
cord-321607-3r736dnk	83	5	role	role	NN
cord-321607-3r736dnk	83	6	for	for	IN
cord-321607-3r736dnk	83	7	RNase	RNase	NNP
cord-321607-3r736dnk	83	8	-	-	HYPH
cord-321607-3r736dnk	83	9	L	l	NN
cord-321607-3r736dnk	83	10	regulation	regulation	NN
cord-321607-3r736dnk	83	11	of	of	IN
cord-321607-3r736dnk	83	12	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	83	13	RNAs	rna	NNS
cord-321607-3r736dnk	83	14	is	be	VBZ
cord-321607-3r736dnk	83	15	the	the	DT
cord-321607-3r736dnk	83	16	observation	observation	NN
cord-321607-3r736dnk	83	17	that	that	IN
cord-321607-3r736dnk	83	18	the	the	DT
cord-321607-3r736dnk	83	19	RNase	RNase	NNP
cord-321607-3r736dnk	83	20	-	-	HYPH
cord-321607-3r736dnk	83	21	L	L	NNP
cord-321607-3r736dnk	83	22	regulators	regulator	NNS
cord-321607-3r736dnk	83	23	OAS	OAS	NNP
cord-321607-3r736dnk	83	24	,	,	,
cord-321607-3r736dnk	83	25	RLI	RLI	NNP
cord-321607-3r736dnk	83	26	,	,	,
cord-321607-3r736dnk	83	27	and	and	CC
cord-321607-3r736dnk	83	28	2	2	CD
cord-321607-3r736dnk	83	29	1	1	CD
cord-321607-3r736dnk	83	30	PDE	PDE	NNP
cord-321607-3r736dnk	83	31	have	have	VBP
cord-321607-3r736dnk	83	32	also	also	RB
cord-321607-3r736dnk	83	33	been	be	VBN
cord-321607-3r736dnk	83	34	observed	observe	VBN
cord-321607-3r736dnk	83	35	in	in	IN
cord-321607-3r736dnk	83	36	mitochondria	mitochondrion	NNS
cord-321607-3r736dnk	83	37	,	,	,
cord-321607-3r736dnk	83	38	and	and	CC
cord-321607-3r736dnk	83	39	their	-PRON-	PRP$
cord-321607-3r736dnk	83	40	modulation	modulation	NN
cord-321607-3r736dnk	83	41	impacts	impact	VBZ
cord-321607-3r736dnk	83	42	the	the	DT
cord-321607-3r736dnk	83	43	expression	expression	NN
cord-321607-3r736dnk	83	44	of	of	IN
cord-321607-3r736dnk	83	45	RNase	RNase	NNP
cord-321607-3r736dnk	83	46	-	-	HYPH
cord-321607-3r736dnk	83	47	L	L	NNP
cord-321607-3r736dnk	83	48	mitochondrial	mitochondrial	NN
cord-321607-3r736dnk	83	49	targets	target	NNS
cord-321607-3r736dnk	83	50	correspondingly	correspondingly	RB
cord-321607-3r736dnk	83	51	[	[	-LRB-
cord-321607-3r736dnk	83	52	68	68	CD
cord-321607-3r736dnk	83	53	,	,	,
cord-321607-3r736dnk	83	54	77	77	CD
cord-321607-3r736dnk	83	55	,	,	,
cord-321607-3r736dnk	83	56	78	78	CD
cord-321607-3r736dnk	83	57	]	]	-RRB-
cord-321607-3r736dnk	83	58	.	.	.
cord-321607-3r736dnk	84	1	In	in	IN
cord-321607-3r736dnk	84	2	a	a	DT
cord-321607-3r736dnk	84	3	yeast	yeast	NN
cord-321607-3r736dnk	84	4	-	-	HYPH
cord-321607-3r736dnk	84	5	two	two	CD
cord-321607-3r736dnk	84	6	hybrid	hybrid	JJ
cord-321607-3r736dnk	84	7	screen	screen	NN
cord-321607-3r736dnk	84	8	using	use	VBG
cord-321607-3r736dnk	84	9	RNase	RNase	NNP
cord-321607-3r736dnk	84	10	-	-	HYPH
cord-321607-3r736dnk	84	11	L	L	NNP
cord-321607-3r736dnk	84	12	as	as	IN
cord-321607-3r736dnk	84	13	bait	bait	NN
cord-321607-3r736dnk	84	14	,	,	,
cord-321607-3r736dnk	84	15	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	84	16	translation	translation	NN
cord-321607-3r736dnk	84	17	initiation	initiation	NN
cord-321607-3r736dnk	84	18	factor	factor	NN
cord-321607-3r736dnk	84	19	(	(	-LRB-
cord-321607-3r736dnk	84	20	IF2mt	IF2mt	NNP
cord-321607-3r736dnk	84	21	)	)	-RRB-
cord-321607-3r736dnk	84	22	was	be	VBD
cord-321607-3r736dnk	84	23	isolated	isolate	VBN
cord-321607-3r736dnk	84	24	as	as	IN
cord-321607-3r736dnk	84	25	a	a	DT
cord-321607-3r736dnk	84	26	potential	potential	JJ
cord-321607-3r736dnk	84	27	interactor	interactor	NN
cord-321607-3r736dnk	84	28	and	and	CC
cord-321607-3r736dnk	84	29	confirmed	confirm	VBD
cord-321607-3r736dnk	84	30	in	in	IN
cord-321607-3r736dnk	84	31	rabbit	rabbit	NN
cord-321607-3r736dnk	84	32	reticulocyte	reticulocyte	NNP
cord-321607-3r736dnk	84	33	lysate	lysate	NN
cord-321607-3r736dnk	84	34	.	.	.
cord-321607-3r736dnk	85	1	IF2mt	IF2mt	NNP
cord-321607-3r736dnk	85	2	is	be	VBZ
cord-321607-3r736dnk	85	3	a	a	DT
cord-321607-3r736dnk	85	4	nuclear	nuclear	NN
cord-321607-3r736dnk	85	5	-	-	HYPH
cord-321607-3r736dnk	85	6	encoded	encode	VBN
cord-321607-3r736dnk	85	7	translation	translation	NN
cord-321607-3r736dnk	85	8	factor	factor	NN
cord-321607-3r736dnk	85	9	that	that	WDT
cord-321607-3r736dnk	85	10	delivers	deliver	VBZ
cord-321607-3r736dnk	85	11	N	n	CD
cord-321607-3r736dnk	85	12	-	-	HYPH
cord-321607-3r736dnk	85	13	formyl	formyl	NNP
cord-321607-3r736dnk	85	14	methionyl	methionyl	NNP
cord-321607-3r736dnk	85	15	-	-	HYPH
cord-321607-3r736dnk	85	16	tRNA	tRNA	NNP
cord-321607-3r736dnk	85	17	to	to	IN
cord-321607-3r736dnk	85	18	the	the	DT
cord-321607-3r736dnk	85	19	P	p	NN
cord-321607-3r736dnk	85	20	-	-	HYPH
cord-321607-3r736dnk	85	21	site	site	NN
cord-321607-3r736dnk	85	22	of	of	IN
cord-321607-3r736dnk	85	23	the	the	DT
cord-321607-3r736dnk	85	24	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	85	25	ribosome	ribosome	NN
cord-321607-3r736dnk	85	26	during	during	IN
cord-321607-3r736dnk	85	27	initiation	initiation	NN
cord-321607-3r736dnk	85	28	.	.	.
cord-321607-3r736dnk	86	1	Using	use	VBG
cord-321607-3r736dnk	86	2	a	a	DT
cord-321607-3r736dnk	86	3	human	human	JJ
cord-321607-3r736dnk	86	4	T	t	NN
cord-321607-3r736dnk	86	5	cell	cell	NN
cord-321607-3r736dnk	86	6	lymphoma	lymphoma	NN
cord-321607-3r736dnk	86	7	cell	cell	NN
cord-321607-3r736dnk	86	8	system	system	NN
cord-321607-3r736dnk	86	9	in	in	IN
cord-321607-3r736dnk	86	10	which	which	WDT
cord-321607-3r736dnk	86	11	IFNα	IFNα	NNP
cord-321607-3r736dnk	86	12	induces	induce	VBZ
cord-321607-3r736dnk	86	13	RNase	RNase	NNP
cord-321607-3r736dnk	86	14	-	-	HYPH
cord-321607-3r736dnk	86	15	L	l	NN
cord-321607-3r736dnk	86	16	-	-	HYPH
cord-321607-3r736dnk	86	17	dependent	dependent	JJ
cord-321607-3r736dnk	86	18	mtRNA	mtrna	CD
cord-321607-3r736dnk	86	19	degradation	degradation	NN
cord-321607-3r736dnk	86	20	and	and	CC
cord-321607-3r736dnk	86	21	cell	cell	NN
cord-321607-3r736dnk	86	22	death	death	NN
cord-321607-3r736dnk	86	23	,	,	,
cord-321607-3r736dnk	86	24	it	-PRON-	PRP
cord-321607-3r736dnk	86	25	was	be	VBD
cord-321607-3r736dnk	86	26	shown	show	VBN
cord-321607-3r736dnk	86	27	that	that	IN
cord-321607-3r736dnk	86	28	RNase	RNase	NNP
cord-321607-3r736dnk	86	29	-	-	HYPH
cord-321607-3r736dnk	86	30	L	l	NN
cord-321607-3r736dnk	86	31	activity	activity	NN
cord-321607-3r736dnk	86	32	required	require	VBD
cord-321607-3r736dnk	86	33	active	active	JJ
cord-321607-3r736dnk	86	34	translation	translation	NN
cord-321607-3r736dnk	86	35	.	.	.
cord-321607-3r736dnk	87	1	In	in	IN
cord-321607-3r736dnk	87	2	addition	addition	NN
cord-321607-3r736dnk	87	3	,	,	,
cord-321607-3r736dnk	87	4	if	if	IN
cord-321607-3r736dnk	87	5	excess	excess	JJ
cord-321607-3r736dnk	87	6	IF2mt	IF2mt	NNP
cord-321607-3r736dnk	87	7	was	be	VBD
cord-321607-3r736dnk	87	8	introduced	introduce	VBN
cord-321607-3r736dnk	87	9	to	to	IN
cord-321607-3r736dnk	87	10	the	the	DT
cord-321607-3r736dnk	87	11	system	system	NN
cord-321607-3r736dnk	87	12	so	so	IN
cord-321607-3r736dnk	87	13	that	that	IN
cord-321607-3r736dnk	87	14	RNase	RNase	NNP
cord-321607-3r736dnk	87	15	-	-	HYPH
cord-321607-3r736dnk	87	16	L	L	NNP
cord-321607-3r736dnk	87	17	was	be	VBD
cord-321607-3r736dnk	87	18	competed	compete	VBN
cord-321607-3r736dnk	87	19	away	away	RB
cord-321607-3r736dnk	87	20	from	from	IN
cord-321607-3r736dnk	87	21	translation	translation	NN
cord-321607-3r736dnk	87	22	initiation	initiation	NN
cord-321607-3r736dnk	87	23	complex	complex	RB
cord-321607-3r736dnk	87	24	-	-	HYPH
cord-321607-3r736dnk	87	25	bound	bind	VBN
cord-321607-3r736dnk	87	26	IF2mt	IF2mt	NNP
cord-321607-3r736dnk	87	27	,	,	,
cord-321607-3r736dnk	87	28	the	the	DT
cord-321607-3r736dnk	87	29	degradation	degradation	NN
cord-321607-3r736dnk	87	30	of	of	IN
cord-321607-3r736dnk	87	31	mtRNAs	mtRNAs	NNP
cord-321607-3r736dnk	87	32	was	be	VBD
cord-321607-3r736dnk	87	33	suppressed	suppress	VBN
cord-321607-3r736dnk	87	34	,	,	,
cord-321607-3r736dnk	87	35	resulting	result	VBG
cord-321607-3r736dnk	87	36	in	in	IN
cord-321607-3r736dnk	87	37	an	an	DT
cord-321607-3r736dnk	87	38	increase	increase	NN
cord-321607-3r736dnk	87	39	in	in	IN
cord-321607-3r736dnk	87	40	proliferation	proliferation	NN
cord-321607-3r736dnk	87	41	and	and	CC
cord-321607-3r736dnk	87	42	a	a	DT
cord-321607-3r736dnk	87	43	decrease	decrease	NN
cord-321607-3r736dnk	87	44	in	in	IN
cord-321607-3r736dnk	87	45	apoptotic	apoptotic	JJ
cord-321607-3r736dnk	87	46	signaling	signal	VBG
cord-321607-3r736dnk	87	47	[	[	-LRB-
cord-321607-3r736dnk	87	48	76	76	CD
cord-321607-3r736dnk	87	49	]	]	-RRB-
cord-321607-3r736dnk	87	50	.	.	.
cord-321607-3r736dnk	88	1	These	these	DT
cord-321607-3r736dnk	88	2	data	datum	NNS
cord-321607-3r736dnk	88	3	indicate	indicate	VBP
cord-321607-3r736dnk	88	4	that	that	IN
cord-321607-3r736dnk	88	5	proximity	proximity	NN
cord-321607-3r736dnk	88	6	to	to	IN
cord-321607-3r736dnk	88	7	ribosome	ribosome	NN
cord-321607-3r736dnk	88	8	-	-	HYPH
cord-321607-3r736dnk	88	9	bound	bind	VBN
cord-321607-3r736dnk	88	10	mtRNAs	mtRNAs	NNP
cord-321607-3r736dnk	88	11	is	be	VBZ
cord-321607-3r736dnk	88	12	necessary	necessary	JJ
cord-321607-3r736dnk	88	13	for	for	IN
cord-321607-3r736dnk	88	14	their	-PRON-	PRP$
cord-321607-3r736dnk	88	15	RNase	RNase	NNP
cord-321607-3r736dnk	88	16	-	-	HYPH
cord-321607-3r736dnk	88	17	L	l	NN
cord-321607-3r736dnk	88	18	-	-	HYPH
cord-321607-3r736dnk	88	19	dependent	dependent	JJ
cord-321607-3r736dnk	88	20	degradation	degradation	NN
cord-321607-3r736dnk	88	21	.	.	.
cord-321607-3r736dnk	89	1	Therefore	therefore	RB
cord-321607-3r736dnk	89	2	,	,	,
cord-321607-3r736dnk	89	3	like	like	IN
cord-321607-3r736dnk	89	4	eRF3	eRF3	NNP
cord-321607-3r736dnk	89	5	,	,	,
cord-321607-3r736dnk	89	6	IF2mt	IF2mt	NNP
cord-321607-3r736dnk	89	7	may	may	MD
cord-321607-3r736dnk	89	8	facilitate	facilitate	VB
cord-321607-3r736dnk	89	9	accessibility	accessibility	NN
cord-321607-3r736dnk	89	10	,	,	,
cord-321607-3r736dnk	89	11	while	while	IN
cord-321607-3r736dnk	89	12	other	other	JJ
cord-321607-3r736dnk	89	13	mechanisms	mechanism	NNS
cord-321607-3r736dnk	89	14	must	must	MD
cord-321607-3r736dnk	89	15	exist	exist	VB
cord-321607-3r736dnk	89	16	to	to	TO
cord-321607-3r736dnk	89	17	provide	provide	VB
cord-321607-3r736dnk	89	18	specificity	specificity	NN
cord-321607-3r736dnk	89	19	.	.	.
cord-321607-3r736dnk	90	1	A	a	DT
cord-321607-3r736dnk	90	2	third	third	JJ
cord-321607-3r736dnk	90	3	interacting	interact	VBG
cord-321607-3r736dnk	90	4	protein	protein	NN
cord-321607-3r736dnk	90	5	may	may	MD
cord-321607-3r736dnk	90	6	aid	aid	VB
cord-321607-3r736dnk	90	7	in	in	IN
cord-321607-3r736dnk	90	8	providing	provide	VBG
cord-321607-3r736dnk	90	9	this	this	DT
cord-321607-3r736dnk	90	10	RNase	RNase	NNP
cord-321607-3r736dnk	90	11	-	-	HYPH
cord-321607-3r736dnk	90	12	L	l	NN
cord-321607-3r736dnk	90	13	target	target	NN
cord-321607-3r736dnk	90	14	specificity	specificity	NN
cord-321607-3r736dnk	90	15	.	.	.
cord-321607-3r736dnk	91	1	Our	-PRON-	PRP$
cord-321607-3r736dnk	91	2	lab	lab	NN
cord-321607-3r736dnk	91	3	has	have	VBZ
cord-321607-3r736dnk	91	4	shown	show	VBN
cord-321607-3r736dnk	91	5	that	that	IN
cord-321607-3r736dnk	91	6	TTP	TTP	NNP
cord-321607-3r736dnk	91	7	can	can	MD
cord-321607-3r736dnk	91	8	bind	bind	VB
cord-321607-3r736dnk	91	9	to	to	IN
cord-321607-3r736dnk	91	10	RNase	RNase	NNP
cord-321607-3r736dnk	91	11	-	-	HYPH
cord-321607-3r736dnk	91	12	L	l	NN
cord-321607-3r736dnk	91	13	and	and	CC
cord-321607-3r736dnk	91	14	coordinately	coordinately	RB
cord-321607-3r736dnk	91	15	regulate	regulate	VBP
cord-321607-3r736dnk	91	16	serum	serum	NN
cord-321607-3r736dnk	91	17	response	response	NN
cord-321607-3r736dnk	91	18	factor	factor	NN
cord-321607-3r736dnk	91	19	(	(	-LRB-
cord-321607-3r736dnk	91	20	SRF	SRF	NNP
cord-321607-3r736dnk	91	21	)	)	-RRB-
cord-321607-3r736dnk	92	1	mRNA	mRNA	NNP
cord-321607-3r736dnk	92	2	destabilization	destabilization	NN
cord-321607-3r736dnk	92	3	[	[	-LRB-
cord-321607-3r736dnk	92	4	54	54	CD
cord-321607-3r736dnk	92	5	]	]	-RRB-
cord-321607-3r736dnk	92	6	.	.	.
cord-321607-3r736dnk	93	1	TTP	TTP	NNP
cord-321607-3r736dnk	93	2	is	be	VBZ
cord-321607-3r736dnk	93	3	an	an	DT
cord-321607-3r736dnk	93	4	ARE	are	VBP
cord-321607-3r736dnk	93	5	-	-	HYPH
cord-321607-3r736dnk	93	6	binding	bind	VBG
cord-321607-3r736dnk	93	7	protein	protein	NN
cord-321607-3r736dnk	93	8	that	that	WDT
cord-321607-3r736dnk	93	9	controls	control	VBZ
cord-321607-3r736dnk	93	10	inflammation	inflammation	NN
cord-321607-3r736dnk	93	11	and	and	CC
cord-321607-3r736dnk	93	12	suppresses	suppress	VBZ
cord-321607-3r736dnk	93	13	tumorigenicity	tumorigenicity	NN
cord-321607-3r736dnk	93	14	through	through	IN
cord-321607-3r736dnk	93	15	the	the	DT
cord-321607-3r736dnk	93	16	decay	decay	NN
cord-321607-3r736dnk	93	17	of	of	IN
cord-321607-3r736dnk	93	18	target	target	NN
cord-321607-3r736dnk	93	19	mRNAs	mrnas	CD
cord-321607-3r736dnk	93	20	.	.	.
cord-321607-3r736dnk	94	1	It	-PRON-	PRP
cord-321607-3r736dnk	94	2	binds	bind	VBZ
cord-321607-3r736dnk	94	3	these	these	DT
cord-321607-3r736dnk	94	4	mRNAs	mRNAs	NNPS
cord-321607-3r736dnk	94	5	using	use	VBG
cord-321607-3r736dnk	94	6	two	two	CD
cord-321607-3r736dnk	94	7	zinc	zinc	NN
cord-321607-3r736dnk	94	8	finger	finger	NN
cord-321607-3r736dnk	94	9	domains	domain	NNS
cord-321607-3r736dnk	94	10	,	,	,
cord-321607-3r736dnk	94	11	often	often	RB
cord-321607-3r736dnk	94	12	recognizing	recognize	VBG
cord-321607-3r736dnk	94	13	a	a	DT
cord-321607-3r736dnk	94	14	UUAUUUAUU	UUAUUUAUU	NNP
cord-321607-3r736dnk	94	15	nonamer	nonamer	JJ
cord-321607-3r736dnk	94	16	sequence	sequence	NN
cord-321607-3r736dnk	94	17	,	,	,
cord-321607-3r736dnk	94	18	but	but	CC
cord-321607-3r736dnk	94	19	utilizes	utilize	VBZ
cord-321607-3r736dnk	94	20	other	other	JJ
cord-321607-3r736dnk	94	21	enzymes	enzyme	NNS
cord-321607-3r736dnk	94	22	to	to	TO
cord-321607-3r736dnk	94	23	mediate	mediate	VB
cord-321607-3r736dnk	94	24	degradation	degradation	NN
cord-321607-3r736dnk	94	25	[	[	-LRB-
cord-321607-3r736dnk	94	26	79	79	CD
cord-321607-3r736dnk	94	27	,	,	,
cord-321607-3r736dnk	94	28	80	80	CD
cord-321607-3r736dnk	94	29	]	]	-RRB-
cord-321607-3r736dnk	94	30	.	.	.
cord-321607-3r736dnk	95	1	Our	-PRON-	PRP$
cord-321607-3r736dnk	95	2	data	datum	NNS
cord-321607-3r736dnk	95	3	indicate	indicate	VBP
cord-321607-3r736dnk	95	4	that	that	IN
cord-321607-3r736dnk	95	5	TTP	TTP	NNP
cord-321607-3r736dnk	95	6	may	may	MD
cord-321607-3r736dnk	95	7	guide	guide	VB
cord-321607-3r736dnk	95	8	RNase	RNase	NNP
cord-321607-3r736dnk	95	9	-	-	HYPH
cord-321607-3r736dnk	95	10	L	l	NN
cord-321607-3r736dnk	95	11	to	to	IN
cord-321607-3r736dnk	95	12	specific	specific	JJ
cord-321607-3r736dnk	95	13	targets	target	NNS
cord-321607-3r736dnk	95	14	like	like	IN
cord-321607-3r736dnk	95	15	SRF	SRF	NNP
cord-321607-3r736dnk	95	16	mRNA	mRNA	NNP
cord-321607-3r736dnk	95	17	,	,	,
cord-321607-3r736dnk	95	18	facilitating	facilitate	VBG
cord-321607-3r736dnk	95	19	RNA	RNA	NNP
cord-321607-3r736dnk	95	20	cleavage	cleavage	NN
cord-321607-3r736dnk	95	21	by	by	IN
cord-321607-3r736dnk	95	22	the	the	DT
cord-321607-3r736dnk	95	23	nuclease	nuclease	NN
cord-321607-3r736dnk	95	24	,	,	,
cord-321607-3r736dnk	95	25	possibly	possibly	RB
cord-321607-3r736dnk	95	26	at	at	IN
cord-321607-3r736dnk	95	27	the	the	DT
cord-321607-3r736dnk	95	28	UU	UU	NNP
cord-321607-3r736dnk	95	29	and	and	CC
cord-321607-3r736dnk	95	30	UA	UA	NNP
cord-321607-3r736dnk	95	31	dinucleotide	dinucleotide	NN
cord-321607-3r736dnk	95	32	sites	site	NNS
cord-321607-3r736dnk	95	33	within	within	IN
cord-321607-3r736dnk	95	34	the	the	DT
cord-321607-3r736dnk	95	35	TTP	TTP	NNP
cord-321607-3r736dnk	95	36	nonamer	nonamer	NNP
cord-321607-3r736dnk	95	37	.	.	.
cord-321607-3r736dnk	96	1	TTP	TTP	NNP
cord-321607-3r736dnk	96	2	and	and	CC
cord-321607-3r736dnk	96	3	RNase	RNase	NNP
cord-321607-3r736dnk	96	4	-	-	HYPH
cord-321607-3r736dnk	96	5	L	l	NN
cord-321607-3r736dnk	96	6	share	share	VB
cord-321607-3r736dnk	96	7	a	a	DT
cord-321607-3r736dnk	96	8	subset	subset	NN
cord-321607-3r736dnk	96	9	of	of	IN
cord-321607-3r736dnk	96	10	targeted	target	VBN
cord-321607-3r736dnk	96	11	RNAs	rna	NNS
cord-321607-3r736dnk	96	12	,	,	,
cord-321607-3r736dnk	96	13	including	include	VBG
cord-321607-3r736dnk	96	14	IL-8	il-8	NN
cord-321607-3r736dnk	96	15	,	,	,
cord-321607-3r736dnk	96	16	HMGA2	HMGA2	NNP
cord-321607-3r736dnk	96	17	,	,	,
cord-321607-3r736dnk	96	18	and	and	CC
cord-321607-3r736dnk	96	19	TTP	TTP	NNP
cord-321607-3r736dnk	96	20	itself	-PRON-	PRP
cord-321607-3r736dnk	96	21	,	,	,
cord-321607-3r736dnk	96	22	indicating	indicate	VBG
cord-321607-3r736dnk	96	23	that	that	IN
cord-321607-3r736dnk	96	24	this	this	DT
cord-321607-3r736dnk	96	25	mechanism	mechanism	NN
cord-321607-3r736dnk	96	26	may	may	MD
cord-321607-3r736dnk	96	27	not	not	RB
cord-321607-3r736dnk	96	28	be	be	VB
cord-321607-3r736dnk	96	29	unique	unique	JJ
cord-321607-3r736dnk	96	30	to	to	IN
cord-321607-3r736dnk	96	31	SRF	SRF	NNP
cord-321607-3r736dnk	96	32	[	[	-LRB-
cord-321607-3r736dnk	96	33	54	54	CD
cord-321607-3r736dnk	96	34	]	]	-RRB-
cord-321607-3r736dnk	96	35	.	.	.
cord-321607-3r736dnk	97	1	Also	also	RB
cord-321607-3r736dnk	97	2	lending	lend	VBG
cord-321607-3r736dnk	97	3	support	support	NN
cord-321607-3r736dnk	97	4	to	to	IN
cord-321607-3r736dnk	97	5	this	this	DT
cord-321607-3r736dnk	97	6	cooperative	cooperative	JJ
cord-321607-3r736dnk	97	7	function	function	NN
cord-321607-3r736dnk	97	8	is	be	VBZ
cord-321607-3r736dnk	97	9	the	the	DT
cord-321607-3r736dnk	97	10	identification	identification	NN
cord-321607-3r736dnk	97	11	of	of	IN
cord-321607-3r736dnk	97	12	the	the	DT
cord-321607-3r736dnk	97	13	nuclease	nuclease	NN
cord-321607-3r736dnk	98	1	Regnase-1	Regnase-1	NNP
cord-321607-3r736dnk	98	2	.	.	.
cord-321607-3r736dnk	98	3	Regnase-1	Regnase-1	NNP
cord-321607-3r736dnk	98	4	contains	contain	VBZ
cord-321607-3r736dnk	98	5	both	both	DT
cord-321607-3r736dnk	98	6	endoribonucleolytic	endoribonucleolytic	JJ
cord-321607-3r736dnk	98	7	activity	activity	NN
cord-321607-3r736dnk	98	8	like	like	IN
cord-321607-3r736dnk	98	9	RNase	RNase	NNP
cord-321607-3r736dnk	98	10	-	-	HYPH
cord-321607-3r736dnk	98	11	L	L	NNP
cord-321607-3r736dnk	98	12	,	,	,
cord-321607-3r736dnk	98	13	and	and	CC
cord-321607-3r736dnk	98	14	a	a	DT
cord-321607-3r736dnk	98	15	CCCH	ccch	NN
cord-321607-3r736dnk	98	16	-	-	HYPH
cord-321607-3r736dnk	98	17	type	type	NN
cord-321607-3r736dnk	98	18	zinc	zinc	NN
cord-321607-3r736dnk	98	19	finger	finger	NN
cord-321607-3r736dnk	98	20	that	that	WDT
cord-321607-3r736dnk	98	21	mediates	mediate	VBZ
cord-321607-3r736dnk	98	22	mRNA	mrna	NN
cord-321607-3r736dnk	98	23	binding	bind	VBG
cord-321607-3r736dnk	98	24	similar	similar	JJ
cord-321607-3r736dnk	98	25	to	to	IN
cord-321607-3r736dnk	98	26	TTP	TTP	NNP
cord-321607-3r736dnk	99	1	[	[	-LRB-
cord-321607-3r736dnk	99	2	81	81	CD
cord-321607-3r736dnk	99	3	,	,	,
cord-321607-3r736dnk	99	4	82	82	CD
cord-321607-3r736dnk	99	5	]	]	-RRB-
cord-321607-3r736dnk	99	6	.	.	.
cord-321607-3r736dnk	100	1	It	-PRON-	PRP
cord-321607-3r736dnk	100	2	essentially	essentially	RB
cord-321607-3r736dnk	100	3	combines	combine	VBZ
cord-321607-3r736dnk	100	4	the	the	DT
cord-321607-3r736dnk	100	5	activities	activity	NNS
cord-321607-3r736dnk	100	6	of	of	IN
cord-321607-3r736dnk	100	7	RNase	RNase	NNP
cord-321607-3r736dnk	100	8	-	-	HYPH
cord-321607-3r736dnk	100	9	L	l	NN
cord-321607-3r736dnk	100	10	and	and	CC
cord-321607-3r736dnk	100	11	TTP	TTP	NNP
cord-321607-3r736dnk	100	12	into	into	IN
cord-321607-3r736dnk	100	13	a	a	DT
cord-321607-3r736dnk	100	14	single	single	JJ
cord-321607-3r736dnk	100	15	enzyme	enzyme	NN
cord-321607-3r736dnk	100	16	,	,	,
cord-321607-3r736dnk	100	17	setting	set	VBG
cord-321607-3r736dnk	100	18	precedent	precedent	NN
cord-321607-3r736dnk	100	19	for	for	IN
cord-321607-3r736dnk	100	20	this	this	DT
cord-321607-3r736dnk	100	21	cooperative	cooperative	JJ
cord-321607-3r736dnk	100	22	function	function	NN
cord-321607-3r736dnk	100	23	.	.	.
cord-321607-3r736dnk	101	1	Many	many	JJ
cord-321607-3r736dnk	101	2	RNase	rnase	NN
cord-321607-3r736dnk	101	3	-	-	HYPH
cord-321607-3r736dnk	101	4	L	l	NN
cord-321607-3r736dnk	101	5	substrates	substrate	NNS
cord-321607-3r736dnk	101	6	are	be	VBP
cord-321607-3r736dnk	101	7	not	not	RB
cord-321607-3r736dnk	101	8	shared	share	VBN
cord-321607-3r736dnk	101	9	with	with	IN
cord-321607-3r736dnk	101	10	TTP	TTP	NNP
cord-321607-3r736dnk	101	11	,	,	,
cord-321607-3r736dnk	101	12	indicating	indicate	VBG
cord-321607-3r736dnk	101	13	that	that	IN
cord-321607-3r736dnk	101	14	additional	additional	JJ
cord-321607-3r736dnk	101	15	mechanisms	mechanism	NNS
cord-321607-3r736dnk	101	16	are	be	VBP
cord-321607-3r736dnk	101	17	likely	likely	RB
cord-321607-3r736dnk	101	18	involved	involve	VBN
cord-321607-3r736dnk	101	19	and	and	CC
cord-321607-3r736dnk	101	20	other	other	JJ
cord-321607-3r736dnk	101	21	ARE	are	VBP
cord-321607-3r736dnk	101	22	-	-	HYPH
cord-321607-3r736dnk	101	23	binding	bind	VBG
cord-321607-3r736dnk	101	24	proteins	protein	NNS
cord-321607-3r736dnk	101	25	(	(	-LRB-
cord-321607-3r736dnk	101	26	AREBP	AREBP	NNP
cord-321607-3r736dnk	101	27	)	)	-RRB-
cord-321607-3r736dnk	101	28	may	may	MD
cord-321607-3r736dnk	101	29	serve	serve	VB
cord-321607-3r736dnk	101	30	as	as	IN
cord-321607-3r736dnk	101	31	potential	potential	JJ
cord-321607-3r736dnk	101	32	targeting	target	VBG
cord-321607-3r736dnk	101	33	candidates	candidate	NNS
cord-321607-3r736dnk	101	34	.	.	.
cord-321607-3r736dnk	102	1	AREBP	AREBP	NNP
cord-321607-3r736dnk	102	2	post	post	JJ
cord-321607-3r736dnk	102	3	-	-	JJ
cord-321607-3r736dnk	102	4	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	102	5	regulators	regulator	NNS
cord-321607-3r736dnk	102	6	are	be	VBP
cord-321607-3r736dnk	102	7	strong	strong	JJ
cord-321607-3r736dnk	102	8	contenders	contender	NNS
cord-321607-3r736dnk	102	9	because	because	IN
cord-321607-3r736dnk	102	10	although	although	IN
cord-321607-3r736dnk	102	11	no	no	DT
cord-321607-3r736dnk	102	12	definitive	definitive	JJ
cord-321607-3r736dnk	102	13	consensus	consensus	NN
cord-321607-3r736dnk	102	14	recognition	recognition	NN
cord-321607-3r736dnk	102	15	site	site	NN
cord-321607-3r736dnk	102	16	exists	exist	VBZ
cord-321607-3r736dnk	102	17	for	for	IN
cord-321607-3r736dnk	102	18	RNase	RNase	NNP
cord-321607-3r736dnk	102	19	-	-	HYPH
cord-321607-3r736dnk	102	20	L	L	NNP
cord-321607-3r736dnk	102	21	,	,	,
cord-321607-3r736dnk	102	22	its	-PRON-	PRP$
cord-321607-3r736dnk	102	23	preference	preference	NN
cord-321607-3r736dnk	102	24	for	for	IN
cord-321607-3r736dnk	102	25	UU	UU	NNP
cord-321607-3r736dnk	102	26	and	and	CC
cord-321607-3r736dnk	102	27	UA	UA	NNP
cord-321607-3r736dnk	102	28	dinucleotides	dinucleotides	NNP
cord-321607-3r736dnk	102	29	is	be	VBZ
cord-321607-3r736dnk	102	30	identical	identical	JJ
cord-321607-3r736dnk	102	31	to	to	IN
cord-321607-3r736dnk	102	32	those	those	DT
cord-321607-3r736dnk	102	33	found	find	VBN
cord-321607-3r736dnk	102	34	in	in	IN
cord-321607-3r736dnk	102	35	AREs	are	NNS
cord-321607-3r736dnk	102	36	.	.	.
cord-321607-3r736dnk	103	1	RNase	RNase	NNP
cord-321607-3r736dnk	103	2	-	-	HYPH
cord-321607-3r736dnk	103	3	L	L	NNP
cord-321607-3r736dnk	103	4	was	be	VBD
cord-321607-3r736dnk	103	5	initially	initially	RB
cord-321607-3r736dnk	103	6	discovered	discover	VBN
cord-321607-3r736dnk	103	7	and	and	CC
cord-321607-3r736dnk	103	8	characterized	characterize	VBN
cord-321607-3r736dnk	103	9	as	as	IN
cord-321607-3r736dnk	103	10	a	a	DT
cord-321607-3r736dnk	103	11	mediator	mediator	NN
cord-321607-3r736dnk	103	12	of	of	IN
cord-321607-3r736dnk	103	13	type	type	NN
cord-321607-3r736dnk	103	14	I	-PRON-	PRP
cord-321607-3r736dnk	103	15	IFN	IFN	NNP
cord-321607-3r736dnk	103	16	antiviral	antiviral	JJ
cord-321607-3r736dnk	103	17	activity	activity	NN
cord-321607-3r736dnk	103	18	.	.	.
cord-321607-3r736dnk	104	1	Although	although	IN
cord-321607-3r736dnk	104	2	cleavage	cleavage	NN
cord-321607-3r736dnk	104	3	of	of	IN
cord-321607-3r736dnk	104	4	RNA	RNA	NNP
cord-321607-3r736dnk	104	5	virus	virus	NN
cord-321607-3r736dnk	104	6	genomes	genome	NNS
cord-321607-3r736dnk	104	7	appeared	appear	VBD
cord-321607-3r736dnk	104	8	as	as	IN
cord-321607-3r736dnk	104	9	the	the	DT
cord-321607-3r736dnk	104	10	most	most	RBS
cord-321607-3r736dnk	104	11	direct	direct	JJ
cord-321607-3r736dnk	104	12	mechanism	mechanism	NN
cord-321607-3r736dnk	104	13	of	of	IN
cord-321607-3r736dnk	104	14	action	action	NN
cord-321607-3r736dnk	104	15	,	,	,
cord-321607-3r736dnk	104	16	other	other	JJ
cord-321607-3r736dnk	104	17	important	important	JJ
cord-321607-3r736dnk	104	18	pathways	pathway	NNS
cord-321607-3r736dnk	104	19	have	have	VBP
cord-321607-3r736dnk	104	20	become	become	VBN
cord-321607-3r736dnk	104	21	evident	evident	JJ
cord-321607-3r736dnk	104	22	,	,	,
cord-321607-3r736dnk	104	23	such	such	JJ
cord-321607-3r736dnk	104	24	as	as	IN
cord-321607-3r736dnk	104	25	the	the	DT
cord-321607-3r736dnk	104	26	regulation	regulation	NN
cord-321607-3r736dnk	104	27	of	of	IN
cord-321607-3r736dnk	104	28	host	host	NN
cord-321607-3r736dnk	104	29	gene	gene	NN
cord-321607-3r736dnk	104	30	expression	expression	NN
cord-321607-3r736dnk	104	31	,	,	,
cord-321607-3r736dnk	104	32	stimulation	stimulation	NN
cord-321607-3r736dnk	104	33	of	of	IN
cord-321607-3r736dnk	104	34	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	104	35	production	production	NN
cord-321607-3r736dnk	104	36	,	,	,
cord-321607-3r736dnk	104	37	activation	activation	NN
cord-321607-3r736dnk	104	38	of	of	IN
cord-321607-3r736dnk	104	39	the	the	DT
cord-321607-3r736dnk	104	40	NACHT	NACHT	NNP
cord-321607-3r736dnk	104	41	,	,	,
cord-321607-3r736dnk	104	42	LRR	LRR	NNP
cord-321607-3r736dnk	104	43	,	,	,
cord-321607-3r736dnk	104	44	and	and	CC
cord-321607-3r736dnk	104	45	PYD	PYD	NNP
cord-321607-3r736dnk	104	46	-	-	HYPH
cord-321607-3r736dnk	104	47	containing	contain	VBG
cord-321607-3r736dnk	104	48	protein-3	protein-3	NN
cord-321607-3r736dnk	104	49	(	(	-LRB-
cord-321607-3r736dnk	104	50	NLRP3	NLRP3	NNP
cord-321607-3r736dnk	104	51	)	)	-RRB-
cord-321607-3r736dnk	104	52	inflammasome	inflammasome	NN
cord-321607-3r736dnk	104	53	,	,	,
cord-321607-3r736dnk	104	54	and	and	CC
cord-321607-3r736dnk	104	55	maintenance	maintenance	NN
cord-321607-3r736dnk	104	56	of	of	IN
cord-321607-3r736dnk	104	57	the	the	DT
cord-321607-3r736dnk	104	58	cell	cell	NN
cord-321607-3r736dnk	104	59	's	's	POS
cord-321607-3r736dnk	104	60	structural	structural	JJ
cord-321607-3r736dnk	104	61	barrier	barrier	NN
cord-321607-3r736dnk	104	62	to	to	IN
cord-321607-3r736dnk	104	63	infection	infection	NN
cord-321607-3r736dnk	104	64	[	[	-LRB-
cord-321607-3r736dnk	104	65	27	27	CD
cord-321607-3r736dnk	104	66	,	,	,
cord-321607-3r736dnk	104	67	55	55	CD
cord-321607-3r736dnk	104	68	,	,	,
cord-321607-3r736dnk	104	69	83	83	CD
cord-321607-3r736dnk	104	70	,	,	,
cord-321607-3r736dnk	104	71	84	84	CD
cord-321607-3r736dnk	104	72	]	]	-RRB-
cord-321607-3r736dnk	104	73	.	.	.
cord-321607-3r736dnk	105	1	These	these	DT
cord-321607-3r736dnk	105	2	will	will	MD
cord-321607-3r736dnk	105	3	be	be	VB
cord-321607-3r736dnk	105	4	discussed	discuss	VBN
cord-321607-3r736dnk	105	5	in	in	IN
cord-321607-3r736dnk	105	6	further	further	JJ
cord-321607-3r736dnk	105	7	detail	detail	NN
cord-321607-3r736dnk	105	8	below	below	RB
cord-321607-3r736dnk	105	9	.	.	.
cord-321607-3r736dnk	106	1	Here	here	RB
cord-321607-3r736dnk	106	2	we	-PRON-	PRP
cord-321607-3r736dnk	106	3	highlight	highlight	VBP
cord-321607-3r736dnk	106	4	some	some	DT
cord-321607-3r736dnk	106	5	of	of	IN
cord-321607-3r736dnk	106	6	the	the	DT
cord-321607-3r736dnk	106	7	decades	decade	NNS
cord-321607-3r736dnk	106	8	of	of	IN
cord-321607-3r736dnk	106	9	work	work	NN
cord-321607-3r736dnk	106	10	demonstrating	demonstrate	VBG
cord-321607-3r736dnk	106	11	the	the	DT
cord-321607-3r736dnk	106	12	importance	importance	NN
cord-321607-3r736dnk	106	13	of	of	IN
cord-321607-3r736dnk	106	14	RNase	RNase	NNP
cord-321607-3r736dnk	106	15	-	-	HYPH
cord-321607-3r736dnk	106	16	L	l	NN
cord-321607-3r736dnk	106	17	to	to	IN
cord-321607-3r736dnk	106	18	the	the	DT
cord-321607-3r736dnk	106	19	replication	replication	NN
cord-321607-3r736dnk	106	20	and	and	CC
cord-321607-3r736dnk	106	21	survival	survival	NN
cord-321607-3r736dnk	106	22	of	of	IN
cord-321607-3r736dnk	106	23	specific	specific	JJ
cord-321607-3r736dnk	106	24	viruses	virus	NNS
cord-321607-3r736dnk	106	25	;	;	:
cord-321607-3r736dnk	106	26	a	a	DT
cord-321607-3r736dnk	106	27	full	full	JJ
cord-321607-3r736dnk	106	28	examination	examination	NN
cord-321607-3r736dnk	106	29	of	of	IN
cord-321607-3r736dnk	106	30	this	this	DT
cord-321607-3r736dnk	106	31	subject	subject	NN
cord-321607-3r736dnk	106	32	is	be	VBZ
cord-321607-3r736dnk	106	33	provided	provide	VBN
cord-321607-3r736dnk	106	34	by	by	IN
cord-321607-3r736dnk	106	35	R.H.	R.H.	NNP
cord-321607-3r736dnk	106	36	Silverman	Silverman	NNP
cord-321607-3r736dnk	106	37	[	[	-LRB-
cord-321607-3r736dnk	106	38	85	85	CD
cord-321607-3r736dnk	106	39	]	]	-RRB-
cord-321607-3r736dnk	106	40	.	.	.
cord-321607-3r736dnk	107	1	RNase	RNase	NNP
cord-321607-3r736dnk	107	2	-	-	HYPH
cord-321607-3r736dnk	107	3	L	L	NNP
cord-321607-3r736dnk	107	4	has	have	VBZ
cord-321607-3r736dnk	107	5	been	be	VBN
cord-321607-3r736dnk	107	6	shown	show	VBN
cord-321607-3r736dnk	107	7	to	to	TO
cord-321607-3r736dnk	107	8	play	play	VB
cord-321607-3r736dnk	107	9	a	a	DT
cord-321607-3r736dnk	107	10	role	role	NN
cord-321607-3r736dnk	107	11	in	in	IN
cord-321607-3r736dnk	107	12	antiviral	antiviral	JJ
cord-321607-3r736dnk	107	13	activity	activity	NN
cord-321607-3r736dnk	107	14	against	against	IN
cord-321607-3r736dnk	107	15	both	both	DT
cord-321607-3r736dnk	107	16	RNA	RNA	NNP
cord-321607-3r736dnk	107	17	viruses	virus	NNS
cord-321607-3r736dnk	107	18	(	(	-LRB-
cord-321607-3r736dnk	107	19	Picornaviridae	Picornaviridae	NNP
cord-321607-3r736dnk	107	20	,	,	,
cord-321607-3r736dnk	107	21	Reoviridae	Reoviridae	NNP
cord-321607-3r736dnk	107	22	,	,	,
cord-321607-3r736dnk	107	23	Togaviridae	Togaviridae	NNP
cord-321607-3r736dnk	107	24	,	,	,
cord-321607-3r736dnk	107	25	Paramyxoviridae	Paramyxoviridae	NNP
cord-321607-3r736dnk	107	26	,	,	,
cord-321607-3r736dnk	107	27	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-321607-3r736dnk	107	28	,	,	,
cord-321607-3r736dnk	107	29	Flaviviridae	Flaviviridae	NNP
cord-321607-3r736dnk	107	30	,	,	,
cord-321607-3r736dnk	107	31	Coronaviridae	Coronaviridae	NNP
cord-321607-3r736dnk	107	32	and	and	CC
cord-321607-3r736dnk	107	33	Retroviridae	Retroviridae	NNP
cord-321607-3r736dnk	107	34	)	)	-RRB-
cord-321607-3r736dnk	107	35	and	and	CC
cord-321607-3r736dnk	107	36	DNA	dna	NN
cord-321607-3r736dnk	107	37	viruses	virus	NNS
cord-321607-3r736dnk	107	38	(	(	-LRB-
cord-321607-3r736dnk	107	39	Poxviridae	Poxviridae	NNP
cord-321607-3r736dnk	107	40	,	,	,
cord-321607-3r736dnk	107	41	Herpesviridae	Herpesviridae	NNP
cord-321607-3r736dnk	107	42	,	,	,
cord-321607-3r736dnk	107	43	and	and	CC
cord-321607-3r736dnk	107	44	Polyomaviridae	Polyomaviridae	NNP
cord-321607-3r736dnk	107	45	)	)	-RRB-
cord-321607-3r736dnk	107	46	.	.	.
cord-321607-3r736dnk	108	1	The	the	DT
cord-321607-3r736dnk	108	2	prototypical	prototypical	JJ
cord-321607-3r736dnk	108	3	virus	virus	NN
cord-321607-3r736dnk	108	4	for	for	IN
cord-321607-3r736dnk	108	5	demonstrating	demonstrate	VBG
cord-321607-3r736dnk	108	6	RNase	RNase	NNP
cord-321607-3r736dnk	108	7	-	-	HYPH
cord-321607-3r736dnk	108	8	L	l	NN
cord-321607-3r736dnk	108	9	activity	activity	NN
cord-321607-3r736dnk	108	10	is	be	VBZ
cord-321607-3r736dnk	108	11	the	the	DT
cord-321607-3r736dnk	108	12	picornavirus	picornavirus	NNP
cord-321607-3r736dnk	108	13	,	,	,
cord-321607-3r736dnk	108	14	encephalomyocarditis	encephalomyocarditis	NNP
cord-321607-3r736dnk	108	15	virus	virus	NN
cord-321607-3r736dnk	108	16	(	(	-LRB-
cord-321607-3r736dnk	108	17	EMCV	EMCV	NNP
cord-321607-3r736dnk	108	18	)	)	-RRB-
cord-321607-3r736dnk	108	19	.	.	.
cord-321607-3r736dnk	109	1	OAS	OAS	NNP
cord-321607-3r736dnk	109	2	has	have	VBZ
cord-321607-3r736dnk	109	3	been	be	VBN
cord-321607-3r736dnk	109	4	isolated	isolate	VBN
cord-321607-3r736dnk	109	5	while	while	IN
cord-321607-3r736dnk	109	6	bound	bind	VBN
cord-321607-3r736dnk	109	7	to	to	IN
cord-321607-3r736dnk	109	8	both	both	CC
cord-321607-3r736dnk	109	9	the	the	DT
cord-321607-3r736dnk	109	10	positive	positive	JJ
cord-321607-3r736dnk	109	11	and	and	CC
cord-321607-3r736dnk	109	12	negative	negative	JJ
cord-321607-3r736dnk	109	13	strands	strand	NNS
cord-321607-3r736dnk	109	14	of	of	IN
cord-321607-3r736dnk	109	15	the	the	DT
cord-321607-3r736dnk	109	16	EMCV	EMCV	NNP
cord-321607-3r736dnk	109	17	genome	genome	NN
cord-321607-3r736dnk	109	18	,	,	,
cord-321607-3r736dnk	109	19	indicating	indicate	VBG
cord-321607-3r736dnk	109	20	that	that	IN
cord-321607-3r736dnk	109	21	it	-PRON-	PRP
cord-321607-3r736dnk	109	22	can	can	MD
cord-321607-3r736dnk	109	23	be	be	VB
cord-321607-3r736dnk	109	24	activated	activate	VBN
cord-321607-3r736dnk	109	25	by	by	IN
cord-321607-3r736dnk	109	26	the	the	DT
cord-321607-3r736dnk	109	27	double	double	RB
cord-321607-3r736dnk	109	28	-	-	HYPH
cord-321607-3r736dnk	109	29	stranded	strand	VBN
cord-321607-3r736dnk	109	30	replicative	replicative	JJ
cord-321607-3r736dnk	109	31	intermediate	intermediate	JJ
cord-321607-3r736dnk	109	32	of	of	IN
cord-321607-3r736dnk	109	33	the	the	DT
cord-321607-3r736dnk	109	34	positive	positive	JJ
cord-321607-3r736dnk	109	35	-	-	HYPH
cord-321607-3r736dnk	109	36	stranded	strand	VBN
cord-321607-3r736dnk	109	37	RNA	rna	NN
cord-321607-3r736dnk	109	38	genome	genome	NN
cord-321607-3r736dnk	109	39	[	[	-LRB-
cord-321607-3r736dnk	109	40	86	86	CD
cord-321607-3r736dnk	109	41	,	,	,
cord-321607-3r736dnk	109	42	87	87	CD
cord-321607-3r736dnk	109	43	]	]	-RRB-
cord-321607-3r736dnk	109	44	.	.	.
cord-321607-3r736dnk	110	1	Following	follow	VBG
cord-321607-3r736dnk	110	2	2	2	CD
cord-321607-3r736dnk	110	3	-	-	HYPH
cord-321607-3r736dnk	110	4	5A	5a	CD
cord-321607-3r736dnk	110	5	production	production	NN
cord-321607-3r736dnk	110	6	,	,	,
cord-321607-3r736dnk	110	7	activated	activate	VBD
cord-321607-3r736dnk	110	8	RNase	RNase	NNP
cord-321607-3r736dnk	110	9	-	-	HYPH
cord-321607-3r736dnk	110	10	L	L	NNP
cord-321607-3r736dnk	110	11	then	then	RB
cord-321607-3r736dnk	110	12	cleaves	cleave	VBZ
cord-321607-3r736dnk	110	13	both	both	CC
cord-321607-3r736dnk	110	14	cellular	cellular	JJ
cord-321607-3r736dnk	110	15	and	and	CC
cord-321607-3r736dnk	110	16	viral	viral	JJ
cord-321607-3r736dnk	110	17	RNAs	rna	NNS
cord-321607-3r736dnk	110	18	,	,	,
cord-321607-3r736dnk	110	19	which	which	WDT
cord-321607-3r736dnk	110	20	not	not	RB
cord-321607-3r736dnk	110	21	only	only	RB
cord-321607-3r736dnk	110	22	directly	directly	RB
cord-321607-3r736dnk	110	23	inhibits	inhibit	VBZ
cord-321607-3r736dnk	110	24	virus	virus	NN
cord-321607-3r736dnk	110	25	replication	replication	NN
cord-321607-3r736dnk	110	26	,	,	,
cord-321607-3r736dnk	110	27	but	but	CC
cord-321607-3r736dnk	110	28	produces	produce	VBZ
cord-321607-3r736dnk	110	29	small	small	JJ
cord-321607-3r736dnk	110	30	RNAs	rna	NNS
cord-321607-3r736dnk	110	31	capable	capable	JJ
cord-321607-3r736dnk	110	32	of	of	IN
cord-321607-3r736dnk	110	33	stimulating	stimulate	VBG
cord-321607-3r736dnk	110	34	RIG	rig	NN
cord-321607-3r736dnk	110	35	-	-	:
cord-321607-3r736dnk	110	36	I	-PRON-	PRP
cord-321607-3r736dnk	110	37	activation	activation	NN
cord-321607-3r736dnk	110	38	and	and	CC
cord-321607-3r736dnk	110	39	subsequent	subsequent	JJ
cord-321607-3r736dnk	110	40	downstream	downstream	JJ
cord-321607-3r736dnk	110	41	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	110	42	transcription	transcription	NN
cord-321607-3r736dnk	110	43	to	to	TO
cord-321607-3r736dnk	110	44	protect	protect	VB
cord-321607-3r736dnk	110	45	surrounding	surround	VBG
cord-321607-3r736dnk	110	46	tissue	tissue	NN
cord-321607-3r736dnk	110	47	by	by	IN
cord-321607-3r736dnk	110	48	creating	create	VBG
cord-321607-3r736dnk	110	49	an	an	DT
cord-321607-3r736dnk	110	50	antiviral	antiviral	JJ
cord-321607-3r736dnk	110	51	state	state	NN
cord-321607-3r736dnk	110	52	[	[	-LRB-
cord-321607-3r736dnk	110	53	27	27	CD
cord-321607-3r736dnk	110	54	,	,	,
cord-321607-3r736dnk	110	55	53	53	CD
cord-321607-3r736dnk	110	56	]	]	-RRB-
cord-321607-3r736dnk	110	57	.	.	.
cord-321607-3r736dnk	111	1	Overexpression	overexpression	NN
cord-321607-3r736dnk	111	2	of	of	IN
cord-321607-3r736dnk	111	3	RNase	RNase	NNP
cord-321607-3r736dnk	111	4	-	-	HYPH
cord-321607-3r736dnk	111	5	L	L	NNP
cord-321607-3r736dnk	111	6	has	have	VBZ
cord-321607-3r736dnk	111	7	been	be	VBN
cord-321607-3r736dnk	111	8	shown	show	VBN
cord-321607-3r736dnk	111	9	to	to	TO
cord-321607-3r736dnk	111	10	suppress	suppress	VB
cord-321607-3r736dnk	111	11	EMCV	EMCV	NNP
cord-321607-3r736dnk	111	12	replication	replication	NN
cord-321607-3r736dnk	111	13	whereas	whereas	IN
cord-321607-3r736dnk	111	14	dominant	dominant	JJ
cord-321607-3r736dnk	111	15	-	-	HYPH
cord-321607-3r736dnk	111	16	negative	negative	JJ
cord-321607-3r736dnk	111	17	RNase	rnase	NN
cord-321607-3r736dnk	111	18	-	-	HYPH
cord-321607-3r736dnk	111	19	L	L	NNP
cord-321607-3r736dnk	111	20	inhibits	inhibit	VBZ
cord-321607-3r736dnk	111	21	IFN	IFN	NNP
cord-321607-3r736dnk	111	22	-	-	HYPH
cord-321607-3r736dnk	111	23	induced	induce	VBN
cord-321607-3r736dnk	111	24	protection	protection	NN
cord-321607-3r736dnk	111	25	against	against	IN
cord-321607-3r736dnk	111	26	infection	infection	NN
cord-321607-3r736dnk	111	27	,	,	,
cord-321607-3r736dnk	111	28	indicating	indicate	VBG
cord-321607-3r736dnk	111	29	the	the	DT
cord-321607-3r736dnk	111	30	effectiveness	effectiveness	NN
cord-321607-3r736dnk	111	31	of	of	IN
cord-321607-3r736dnk	111	32	RNase	RNase	NNP
cord-321607-3r736dnk	111	33	-	-	HYPH
cord-321607-3r736dnk	111	34	L	l	NN
cord-321607-3r736dnk	111	35	antiviral	antiviral	JJ
cord-321607-3r736dnk	111	36	activity	activity	NN
cord-321607-3r736dnk	111	37	[	[	-LRB-
cord-321607-3r736dnk	111	38	14	14	CD
cord-321607-3r736dnk	111	39	,	,	,
cord-321607-3r736dnk	111	40	53	53	CD
cord-321607-3r736dnk	111	41	]	]	-RRB-
cord-321607-3r736dnk	111	42	.	.	.
cord-321607-3r736dnk	112	1	In	in	IN
cord-321607-3r736dnk	112	2	order	order	NN
cord-321607-3r736dnk	112	3	to	to	TO
cord-321607-3r736dnk	112	4	determine	determine	VB
cord-321607-3r736dnk	112	5	whether	whether	IN
cord-321607-3r736dnk	112	6	these	these	DT
cord-321607-3r736dnk	112	7	effects	effect	NNS
cord-321607-3r736dnk	112	8	were	be	VBD
cord-321607-3r736dnk	112	9	physiologic	physiologic	JJ
cord-321607-3r736dnk	112	10	in	in	IN
cord-321607-3r736dnk	112	11	vivo	vivo	NN
cord-321607-3r736dnk	112	12	,	,	,
cord-321607-3r736dnk	112	13	RNase	RNase	NNP
cord-321607-3r736dnk	112	14	-	-	HYPH
cord-321607-3r736dnk	112	15	L	L	NNP
cord-321607-3r736dnk	112	16	knock	knock	NN
cord-321607-3r736dnk	112	17	-	-	HYPH
cord-321607-3r736dnk	112	18	out	out	NN
cord-321607-3r736dnk	112	19	(	(	-LRB-
cord-321607-3r736dnk	112	20	KO	KO	NNP
cord-321607-3r736dnk	112	21	)	)	-RRB-
cord-321607-3r736dnk	112	22	and	and	CC
cord-321607-3r736dnk	112	23	RNase	RNase	NNP
cord-321607-3r736dnk	112	24	-	-	HYPH
cord-321607-3r736dnk	112	25	L	l	NN
cord-321607-3r736dnk	112	26	wild	wild	JJ
cord-321607-3r736dnk	112	27	type	type	NN
cord-321607-3r736dnk	112	28	(	(	-LRB-
cord-321607-3r736dnk	112	29	WT	WT	NNP
cord-321607-3r736dnk	112	30	)	)	-RRB-
cord-321607-3r736dnk	112	31	mice	mouse	NNS
cord-321607-3r736dnk	112	32	were	be	VBD
cord-321607-3r736dnk	112	33	infected	infect	VBN
cord-321607-3r736dnk	112	34	with	with	IN
cord-321607-3r736dnk	112	35	EMCV	EMCV	NNP
cord-321607-3r736dnk	112	36	,	,	,
cord-321607-3r736dnk	112	37	and	and	CC
cord-321607-3r736dnk	112	38	wild	wild	JJ
cord-321607-3r736dnk	112	39	type	type	NN
cord-321607-3r736dnk	112	40	mice	mouse	NNS
cord-321607-3r736dnk	112	41	exhibited	exhibit	VBD
cord-321607-3r736dnk	112	42	both	both	CC
cord-321607-3r736dnk	112	43	a	a	DT
cord-321607-3r736dnk	112	44	better	well	JJR
cord-321607-3r736dnk	112	45	rate	rate	NN
cord-321607-3r736dnk	112	46	of	of	IN
cord-321607-3r736dnk	112	47	survival	survival	NN
cord-321607-3r736dnk	112	48	and	and	CC
cord-321607-3r736dnk	112	49	delayed	delay	VBN
cord-321607-3r736dnk	112	50	onset	onset	NN
cord-321607-3r736dnk	112	51	of	of	IN
cord-321607-3r736dnk	112	52	death	death	NN
cord-321607-3r736dnk	112	53	as	as	IN
cord-321607-3r736dnk	112	54	compared	compare	VBN
cord-321607-3r736dnk	112	55	to	to	IN
cord-321607-3r736dnk	112	56	knockout	knockout	NN
cord-321607-3r736dnk	112	57	mice	mouse	NNS
cord-321607-3r736dnk	112	58	[	[	-LRB-
cord-321607-3r736dnk	112	59	15	15	CD
cord-321607-3r736dnk	112	60	]	]	-RRB-
cord-321607-3r736dnk	112	61	.	.	.
cord-321607-3r736dnk	113	1	Though	though	IN
cord-321607-3r736dnk	113	2	EMCV	EMCV	NNP
cord-321607-3r736dnk	113	3	is	be	VBZ
cord-321607-3r736dnk	113	4	sensitive	sensitive	JJ
cord-321607-3r736dnk	113	5	to	to	IN
cord-321607-3r736dnk	113	6	RNase	RNase	NNP
cord-321607-3r736dnk	113	7	-	-	HYPH
cord-321607-3r736dnk	113	8	L	l	NN
cord-321607-3r736dnk	113	9	activity	activity	NN
cord-321607-3r736dnk	113	10	,	,	,
cord-321607-3r736dnk	113	11	other	other	JJ
cord-321607-3r736dnk	113	12	members	member	NNS
cord-321607-3r736dnk	113	13	of	of	IN
cord-321607-3r736dnk	113	14	the	the	DT
cord-321607-3r736dnk	113	15	Picornaviridae	Picornaviridae	NNP
cord-321607-3r736dnk	113	16	family	family	NN
cord-321607-3r736dnk	113	17	,	,	,
cord-321607-3r736dnk	113	18	such	such	JJ
cord-321607-3r736dnk	113	19	as	as	IN
cord-321607-3r736dnk	113	20	Theiler	Theiler	NNP
cord-321607-3r736dnk	113	21	's	's	POS
cord-321607-3r736dnk	113	22	virus	virus	NN
cord-321607-3r736dnk	113	23	and	and	CC
cord-321607-3r736dnk	113	24	poliovirus	poliovirus	NN
cord-321607-3r736dnk	113	25	,	,	,
cord-321607-3r736dnk	113	26	have	have	VBP
cord-321607-3r736dnk	113	27	adapted	adapt	VBN
cord-321607-3r736dnk	113	28	mechanisms	mechanism	NNS
cord-321607-3r736dnk	113	29	for	for	IN
cord-321607-3r736dnk	113	30	evading	evade	VBG
cord-321607-3r736dnk	113	31	RNase	RNase	NNP
cord-321607-3r736dnk	113	32	-	-	HYPH
cord-321607-3r736dnk	113	33	L	l	NN
cord-321607-3r736dnk	113	34	activity	activity	NN
cord-321607-3r736dnk	113	35	[	[	-LRB-
cord-321607-3r736dnk	113	36	88	88	CD
cord-321607-3r736dnk	113	37	]	]	-RRB-
cord-321607-3r736dnk	113	38	[	[	-LRB-
cord-321607-3r736dnk	113	39	89	89	CD
cord-321607-3r736dnk	113	40	]	]	-RRB-
cord-321607-3r736dnk	114	1	[	[	-LRB-
cord-321607-3r736dnk	114	2	90	90	CD
cord-321607-3r736dnk	114	3	]	]	-RRB-
cord-321607-3r736dnk	114	4	[	[	-LRB-
cord-321607-3r736dnk	114	5	91	91	CD
cord-321607-3r736dnk	114	6	]	]	-RRB-
cord-321607-3r736dnk	114	7	.	.	.
cord-321607-3r736dnk	115	1	The	the	DT
cord-321607-3r736dnk	115	2	evolution	evolution	NN
cord-321607-3r736dnk	115	3	of	of	IN
cord-321607-3r736dnk	115	4	these	these	DT
cord-321607-3r736dnk	115	5	and	and	CC
cord-321607-3r736dnk	115	6	other	other	JJ
cord-321607-3r736dnk	115	7	inhibitors	inhibitor	NNS
cord-321607-3r736dnk	115	8	are	be	VBP
cord-321607-3r736dnk	115	9	a	a	DT
cord-321607-3r736dnk	115	10	testament	testament	NN
cord-321607-3r736dnk	115	11	to	to	IN
cord-321607-3r736dnk	115	12	the	the	DT
cord-321607-3r736dnk	115	13	antiviral	antiviral	JJ
cord-321607-3r736dnk	115	14	potency	potency	NN
cord-321607-3r736dnk	115	15	of	of	IN
cord-321607-3r736dnk	115	16	the	the	DT
cord-321607-3r736dnk	115	17	OAS	OAS	NNP
cord-321607-3r736dnk	115	18	/	/	SYM
cord-321607-3r736dnk	115	19	RNase	RNase	NNP
cord-321607-3r736dnk	115	20	-	-	HYPH
cord-321607-3r736dnk	115	21	L	L	NNP
cord-321607-3r736dnk	115	22	pathway	pathway	NN
cord-321607-3r736dnk	115	23	.	.	.
cord-321607-3r736dnk	116	1	In	in	IN
cord-321607-3r736dnk	116	2	an	an	DT
cord-321607-3r736dnk	116	3	in	in	FW
cord-321607-3r736dnk	116	4	vitro	vitro	FW
cord-321607-3r736dnk	116	5	hepatitis	hepatitis	NN
cord-321607-3r736dnk	116	6	C	C	NNP
cord-321607-3r736dnk	116	7	virus	virus	NN
cord-321607-3r736dnk	116	8	(	(	-LRB-
cord-321607-3r736dnk	116	9	HCV	HCV	NNP
cord-321607-3r736dnk	116	10	)	)	-RRB-
cord-321607-3r736dnk	116	11	infection	infection	NN
cord-321607-3r736dnk	116	12	model	model	NN
cord-321607-3r736dnk	116	13	,	,	,
cord-321607-3r736dnk	116	14	RNase	RNase	NNP
cord-321607-3r736dnk	116	15	-	-	HYPH
cord-321607-3r736dnk	116	16	L	L	NNP
cord-321607-3r736dnk	116	17	was	be	VBD
cord-321607-3r736dnk	116	18	demonstrated	demonstrate	VBN
cord-321607-3r736dnk	116	19	to	to	TO
cord-321607-3r736dnk	116	20	cleave	cleave	VB
cord-321607-3r736dnk	116	21	the	the	DT
cord-321607-3r736dnk	116	22	genome	genome	NN
cord-321607-3r736dnk	116	23	at	at	IN
cord-321607-3r736dnk	116	24	UU	UU	NNP
cord-321607-3r736dnk	116	25	and	and	CC
cord-321607-3r736dnk	116	26	UA	UA	NNP
cord-321607-3r736dnk	116	27	dinucleotides	dinucleotide	VBZ
cord-321607-3r736dnk	116	28	into	into	IN
cord-321607-3r736dnk	116	29	200	200	CD
cord-321607-3r736dnk	116	30	-	-	SYM
cord-321607-3r736dnk	116	31	500	500	CD
cord-321607-3r736dnk	116	32	bp	bp	NNP
cord-321607-3r736dnk	116	33	fragments	fragment	NNS
cord-321607-3r736dnk	116	34	[	[	-LRB-
cord-321607-3r736dnk	116	35	92	92	CD
cord-321607-3r736dnk	116	36	]	]	-RRB-
cord-321607-3r736dnk	116	37	.	.	.
cord-321607-3r736dnk	117	1	Sequence	sequence	NN
cord-321607-3r736dnk	117	2	analysis	analysis	NN
cord-321607-3r736dnk	117	3	indicated	indicate	VBD
cord-321607-3r736dnk	117	4	that	that	IN
cord-321607-3r736dnk	117	5	UU	UU	NNP
cord-321607-3r736dnk	117	6	and	and	CC
cord-321607-3r736dnk	117	7	UA	UA	NNP
cord-321607-3r736dnk	117	8	dinucleotides	dinucleotide	NNS
cord-321607-3r736dnk	117	9	are	be	VBP
cord-321607-3r736dnk	117	10	underrepresented	underrepresente	VBN
cord-321607-3r736dnk	117	11	in	in	IN
cord-321607-3r736dnk	117	12	the	the	DT
cord-321607-3r736dnk	117	13	HCV	HCV	NNP
cord-321607-3r736dnk	117	14	genome	genome	NN
cord-321607-3r736dnk	117	15	and	and	CC
cord-321607-3r736dnk	117	16	that	that	IN
cord-321607-3r736dnk	117	17	IFN	IFN	NNP
cord-321607-3r736dnk	117	18	-	-	HYPH
cord-321607-3r736dnk	117	19	sensitive	sensitive	JJ
cord-321607-3r736dnk	117	20	HCV	HCV	NNP
cord-321607-3r736dnk	117	21	genotypes	genotype	NNS
cord-321607-3r736dnk	117	22	contain	contain	VBP
cord-321607-3r736dnk	117	23	more	more	JJR
cord-321607-3r736dnk	117	24	UU	UU	NNP
cord-321607-3r736dnk	117	25	and	and	CC
cord-321607-3r736dnk	117	26	UA	UA	NNP
cord-321607-3r736dnk	117	27	dinucleotides	dinucleotide	NNS
cord-321607-3r736dnk	117	28	than	than	IN
cord-321607-3r736dnk	117	29	IFN	IFN	NNP
cord-321607-3r736dnk	117	30	-	-	HYPH
cord-321607-3r736dnk	117	31	resistant	resistant	JJ
cord-321607-3r736dnk	117	32	genotypes	genotype	NNS
cord-321607-3r736dnk	117	33	[	[	-LRB-
cord-321607-3r736dnk	117	34	93	93	CD
cord-321607-3r736dnk	117	35	]	]	-RRB-
cord-321607-3r736dnk	117	36	.	.	.
cord-321607-3r736dnk	118	1	This	this	DT
cord-321607-3r736dnk	118	2	minimizing	minimizing	NN
cord-321607-3r736dnk	118	3	of	of	IN
cord-321607-3r736dnk	118	4	potential	potential	JJ
cord-321607-3r736dnk	118	5	RNase	rnase	NN
cord-321607-3r736dnk	118	6	-	-	HYPH
cord-321607-3r736dnk	118	7	L	l	NN
cord-321607-3r736dnk	118	8	cleavage	cleavage	NN
cord-321607-3r736dnk	118	9	sites	site	NNS
cord-321607-3r736dnk	118	10	could	could	MD
cord-321607-3r736dnk	118	11	be	be	VB
cord-321607-3r736dnk	118	12	an	an	DT
cord-321607-3r736dnk	118	13	effective	effective	JJ
cord-321607-3r736dnk	118	14	evasion	evasion	NN
cord-321607-3r736dnk	118	15	strategy	strategy	NN
cord-321607-3r736dnk	118	16	by	by	IN
cord-321607-3r736dnk	118	17	this	this	DT
cord-321607-3r736dnk	118	18	chronic	chronic	JJ
cord-321607-3r736dnk	118	19	pathogen	pathogen	NN
cord-321607-3r736dnk	118	20	[	[	-LRB-
cord-321607-3r736dnk	118	21	94	94	CD
cord-321607-3r736dnk	118	22	]	]	-RRB-
cord-321607-3r736dnk	118	23	.	.	.
cord-321607-3r736dnk	119	1	Influenza	Influenza	NNP
cord-321607-3r736dnk	119	2	A	a	DT
cord-321607-3r736dnk	119	3	virus	virus	NN
cord-321607-3r736dnk	119	4	(	(	-LRB-
cord-321607-3r736dnk	119	5	IAV	IAV	NNP
cord-321607-3r736dnk	119	6	)	)	-RRB-
cord-321607-3r736dnk	119	7	has	have	VBZ
cord-321607-3r736dnk	119	8	also	also	RB
cord-321607-3r736dnk	119	9	been	be	VBN
cord-321607-3r736dnk	119	10	shown	show	VBN
cord-321607-3r736dnk	119	11	to	to	TO
cord-321607-3r736dnk	119	12	be	be	VB
cord-321607-3r736dnk	119	13	cleaved	cleave	VBN
cord-321607-3r736dnk	119	14	at	at	IN
cord-321607-3r736dnk	119	15	discrete	discrete	JJ
cord-321607-3r736dnk	119	16	locations	location	NNS
cord-321607-3r736dnk	119	17	in	in	IN
cord-321607-3r736dnk	119	18	both	both	CC
cord-321607-3r736dnk	119	19	the	the	DT
cord-321607-3r736dnk	119	20	positive	positive	JJ
cord-321607-3r736dnk	119	21	and	and	CC
cord-321607-3r736dnk	119	22	negative	negative	JJ
cord-321607-3r736dnk	119	23	RNA	RNA	NNP
cord-321607-3r736dnk	119	24	strands	strand	NNS
cord-321607-3r736dnk	119	25	of	of	IN
cord-321607-3r736dnk	119	26	the	the	DT
cord-321607-3r736dnk	119	27	replicative	replicative	JJ
cord-321607-3r736dnk	119	28	intermediate	intermediate	JJ
cord-321607-3r736dnk	119	29	genome	genome	NN
cord-321607-3r736dnk	119	30	,	,	,
cord-321607-3r736dnk	119	31	but	but	CC
cord-321607-3r736dnk	119	32	only	only	RB
cord-321607-3r736dnk	119	33	in	in	IN
cord-321607-3r736dnk	119	34	the	the	DT
cord-321607-3r736dnk	119	35	absence	absence	NN
cord-321607-3r736dnk	119	36	of	of	IN
cord-321607-3r736dnk	119	37	the	the	DT
cord-321607-3r736dnk	119	38	IFN	IFN	NNP
cord-321607-3r736dnk	119	39	inhibitor	inhibitor	NN
cord-321607-3r736dnk	119	40	NS1	ns1	NN
cord-321607-3r736dnk	119	41	[	[	-LRB-
cord-321607-3r736dnk	119	42	95	95	CD
cord-321607-3r736dnk	119	43	,	,	,
cord-321607-3r736dnk	119	44	96	96	CD
cord-321607-3r736dnk	119	45	]	]	-RRB-
cord-321607-3r736dnk	119	46	.	.	.
cord-321607-3r736dnk	120	1	NS1	ns1	UH
cord-321607-3r736dnk	120	2	binds	bind	VBZ
cord-321607-3r736dnk	120	3	to	to	IN
cord-321607-3r736dnk	120	4	and	and	CC
cord-321607-3r736dnk	120	5	sequesters	sequester	VBZ
cord-321607-3r736dnk	120	6	dsRNA	dsrna	NN
cord-321607-3r736dnk	120	7	in	in	IN
cord-321607-3r736dnk	120	8	order	order	NN
cord-321607-3r736dnk	120	9	to	to	TO
cord-321607-3r736dnk	120	10	prevent	prevent	VB
cord-321607-3r736dnk	120	11	the	the	DT
cord-321607-3r736dnk	120	12	activation	activation	NN
cord-321607-3r736dnk	120	13	of	of	IN
cord-321607-3r736dnk	120	14	the	the	DT
cord-321607-3r736dnk	120	15	viral	viral	JJ
cord-321607-3r736dnk	120	16	sensors	sensor	NNS
cord-321607-3r736dnk	120	17	RIG	rig	NN
cord-321607-3r736dnk	120	18	-	-	:
cord-321607-3r736dnk	120	19	I	I	NNP
cord-321607-3r736dnk	120	20	,	,	,
cord-321607-3r736dnk	120	21	OAS	OAS	NNP
cord-321607-3r736dnk	120	22	,	,	,
cord-321607-3r736dnk	120	23	and	and	CC
cord-321607-3r736dnk	120	24	the	the	DT
cord-321607-3r736dnk	120	25	IFN	IFN	NNP
cord-321607-3r736dnk	120	26	-	-	HYPH
cord-321607-3r736dnk	120	27	induced	induce	VBN
cord-321607-3r736dnk	120	28	protein	protein	NN
cord-321607-3r736dnk	120	29	kinase	kinase	VBZ
cord-321607-3r736dnk	120	30	PKR	PKR	NNP
cord-321607-3r736dnk	120	31	[	[	-LRB-
cord-321607-3r736dnk	120	32	97	97	CD
cord-321607-3r736dnk	120	33	]	]	-RRB-
cord-321607-3r736dnk	120	34	.	.	.
cord-321607-3r736dnk	121	1	Since	since	IN
cord-321607-3r736dnk	121	2	this	this	DT
cord-321607-3r736dnk	121	3	mechanism	mechanism	NN
cord-321607-3r736dnk	121	4	not	not	RB
cord-321607-3r736dnk	121	5	only	only	RB
cord-321607-3r736dnk	121	6	inhibits	inhibit	VBZ
cord-321607-3r736dnk	121	7	the	the	DT
cord-321607-3r736dnk	121	8	OAS	OAS	NNP
cord-321607-3r736dnk	121	9	/	/	SYM
cord-321607-3r736dnk	121	10	RNase	RNase	NNP
cord-321607-3r736dnk	121	11	-	-	HYPH
cord-321607-3r736dnk	121	12	L	L	NNP
cord-321607-3r736dnk	121	13	pathway	pathway	NN
cord-321607-3r736dnk	121	14	,	,	,
cord-321607-3r736dnk	121	15	but	but	CC
cord-321607-3r736dnk	121	16	other	other	JJ
cord-321607-3r736dnk	121	17	potent	potent	JJ
cord-321607-3r736dnk	121	18	antiviral	antiviral	JJ
cord-321607-3r736dnk	121	19	actions	action	NNS
cord-321607-3r736dnk	121	20	including	include	VBG
cord-321607-3r736dnk	121	21	the	the	DT
cord-321607-3r736dnk	121	22	induction	induction	NN
cord-321607-3r736dnk	121	23	of	of	IN
cord-321607-3r736dnk	121	24	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	121	25	,	,	,
cord-321607-3r736dnk	121	26	other	other	JJ
cord-321607-3r736dnk	121	27	viruses	virus	NNS
cord-321607-3r736dnk	121	28	such	such	JJ
cord-321607-3r736dnk	121	29	as	as	IN
cord-321607-3r736dnk	121	30	vaccinia	vaccinia	NN
cord-321607-3r736dnk	121	31	virus	virus	NN
cord-321607-3r736dnk	121	32	,	,	,
cord-321607-3r736dnk	121	33	human	human	JJ
cord-321607-3r736dnk	121	34	immunodeficiency	immunodeficiency	NN
cord-321607-3r736dnk	121	35	virus	virus	NN
cord-321607-3r736dnk	121	36	(	(	-LRB-
cord-321607-3r736dnk	121	37	HIV	HIV	NNP
cord-321607-3r736dnk	121	38	)	)	-RRB-
cord-321607-3r736dnk	121	39	,	,	,
cord-321607-3r736dnk	121	40	and	and	CC
cord-321607-3r736dnk	121	41	reovirus	reovirus	NNP
cord-321607-3r736dnk	121	42	,	,	,
cord-321607-3r736dnk	121	43	have	have	VBP
cord-321607-3r736dnk	121	44	also	also	RB
cord-321607-3r736dnk	121	45	adopted	adopt	VBN
cord-321607-3r736dnk	121	46	this	this	DT
cord-321607-3r736dnk	121	47	strategy	strategy	NN
cord-321607-3r736dnk	121	48	[	[	-LRB-
cord-321607-3r736dnk	121	49	85	85	CD
cord-321607-3r736dnk	121	50	]	]	-RRB-
cord-321607-3r736dnk	121	51	.	.	.
cord-321607-3r736dnk	122	1	This	this	DT
cord-321607-3r736dnk	122	2	sequestration	sequestration	NN
cord-321607-3r736dnk	122	3	of	of	IN
cord-321607-3r736dnk	122	4	activating	activate	VBG
cord-321607-3r736dnk	122	5	RNAs	rna	NNS
cord-321607-3r736dnk	122	6	may	may	MD
cord-321607-3r736dnk	122	7	not	not	RB
cord-321607-3r736dnk	122	8	be	be	VB
cord-321607-3r736dnk	122	9	completely	completely	RB
cord-321607-3r736dnk	122	10	efficient	efficient	JJ
cord-321607-3r736dnk	122	11	throughout	throughout	IN
cord-321607-3r736dnk	122	12	the	the	DT
cord-321607-3r736dnk	122	13	course	course	NN
cord-321607-3r736dnk	122	14	of	of	IN
cord-321607-3r736dnk	122	15	infection	infection	NN
cord-321607-3r736dnk	122	16	,	,	,
cord-321607-3r736dnk	122	17	potentially	potentially	RB
cord-321607-3r736dnk	122	18	resulting	result	VBG
cord-321607-3r736dnk	122	19	in	in	IN
cord-321607-3r736dnk	122	20	low	low	JJ
cord-321607-3r736dnk	122	21	levels	level	NNS
cord-321607-3r736dnk	122	22	of	of	IN
cord-321607-3r736dnk	122	23	free	free	JJ
cord-321607-3r736dnk	122	24	2	2	CD
cord-321607-3r736dnk	122	25	-	-	SYM
cord-321607-3r736dnk	122	26	5A.	5a.	CD
cord-321607-3r736dnk	123	1	Therefore	therefore	RB
cord-321607-3r736dnk	123	2	,	,	,
cord-321607-3r736dnk	123	3	HIV	HIV	NNP
cord-321607-3r736dnk	123	4	also	also	RB
cord-321607-3r736dnk	123	5	induces	induce	VBZ
cord-321607-3r736dnk	123	6	the	the	DT
cord-321607-3r736dnk	123	7	expression	expression	NN
cord-321607-3r736dnk	123	8	of	of	IN
cord-321607-3r736dnk	123	9	RLI	RLI	NNP
cord-321607-3r736dnk	123	10	to	to	TO
cord-321607-3r736dnk	123	11	prevent	prevent	VB
cord-321607-3r736dnk	123	12	the	the	DT
cord-321607-3r736dnk	123	13	binding	binding	NN
cord-321607-3r736dnk	123	14	of	of	IN
cord-321607-3r736dnk	123	15	any	any	DT
cord-321607-3r736dnk	123	16	free	free	JJ
cord-321607-3r736dnk	123	17	2	2	CD
cord-321607-3r736dnk	123	18	-	-	HYPH
cord-321607-3r736dnk	123	19	5A	5a	NN
cord-321607-3r736dnk	123	20	to	to	IN
cord-321607-3r736dnk	123	21	RNase	RNase	NNP
cord-321607-3r736dnk	123	22	-	-	HYPH
cord-321607-3r736dnk	123	23	L	l	NN
cord-321607-3r736dnk	123	24	,	,	,
cord-321607-3r736dnk	123	25	further	further	RB
cord-321607-3r736dnk	123	26	safeguarding	safeguard	VBG
cord-321607-3r736dnk	123	27	against	against	IN
cord-321607-3r736dnk	123	28	activation	activation	NN
cord-321607-3r736dnk	123	29	[	[	-LRB-
cord-321607-3r736dnk	123	30	70	70	CD
cord-321607-3r736dnk	123	31	,	,	,
cord-321607-3r736dnk	123	32	98	98	CD
cord-321607-3r736dnk	123	33	]	]	-RRB-
cord-321607-3r736dnk	123	34	.	.	.
cord-321607-3r736dnk	124	1	A	a	DT
cord-321607-3r736dnk	124	2	relatively	relatively	RB
cord-321607-3r736dnk	124	3	new	new	JJ
cord-321607-3r736dnk	124	4	mechanism	mechanism	NN
cord-321607-3r736dnk	124	5	for	for	IN
cord-321607-3r736dnk	124	6	inhibiting	inhibit	VBG
cord-321607-3r736dnk	124	7	RNase	RNase	NNP
cord-321607-3r736dnk	124	8	-	-	HYPH
cord-321607-3r736dnk	124	9	L	l	NN
cord-321607-3r736dnk	124	10	activity	activity	NN
cord-321607-3r736dnk	124	11	was	be	VBD
cord-321607-3r736dnk	124	12	identified	identify	VBN
cord-321607-3r736dnk	124	13	in	in	IN
cord-321607-3r736dnk	124	14	the	the	DT
cord-321607-3r736dnk	124	15	coronavirus	coronavirus	NN
cord-321607-3r736dnk	124	16	mouse	mouse	NN
cord-321607-3r736dnk	124	17	hepatitis	hepatitis	NN
cord-321607-3r736dnk	124	18	virus	virus	NN
cord-321607-3r736dnk	124	19	(	(	-LRB-
cord-321607-3r736dnk	124	20	MHV	MHV	NNP
cord-321607-3r736dnk	124	21	)	)	-RRB-
cord-321607-3r736dnk	124	22	.	.	.
cord-321607-3r736dnk	125	1	The	the	DT
cord-321607-3r736dnk	125	2	MHV	MHV	NNP
cord-321607-3r736dnk	125	3	ns2	ns2	NNP
cord-321607-3r736dnk	125	4	gene	gene	NN
cord-321607-3r736dnk	125	5	encodes	encode	VBZ
cord-321607-3r736dnk	125	6	its	-PRON-	PRP$
cord-321607-3r736dnk	125	7	own	own	JJ
cord-321607-3r736dnk	125	8	2	2	CD
cord-321607-3r736dnk	125	9	1	1	CD
cord-321607-3r736dnk	125	10	phosphodiesterase	phosphodiesterase	NN
cord-321607-3r736dnk	125	11	to	to	TO
cord-321607-3r736dnk	125	12	degrade	degrade	VB
cord-321607-3r736dnk	125	13	2	2	CD
cord-321607-3r736dnk	125	14	-	-	SYM
cord-321607-3r736dnk	125	15	5A.	5a.	CD
cord-321607-3r736dnk	126	1	When	when	WRB
cord-321607-3r736dnk	126	2	compared	compare	VBN
cord-321607-3r736dnk	126	3	to	to	IN
cord-321607-3r736dnk	126	4	wild	wild	JJ
cord-321607-3r736dnk	126	5	type	type	NN
cord-321607-3r736dnk	126	6	virus	virus	NN
cord-321607-3r736dnk	126	7	,	,	,
cord-321607-3r736dnk	126	8	the	the	DT
cord-321607-3r736dnk	126	9	mutant	mutant	JJ
cord-321607-3r736dnk	126	10	virus	virus	NN
cord-321607-3r736dnk	126	11	ns2-H126R	ns2-H126R	NNP
cord-321607-3r736dnk	126	12	that	that	WDT
cord-321607-3r736dnk	126	13	expresses	express	VBZ
cord-321607-3r736dnk	126	14	catalytically	catalytically	RB
cord-321607-3r736dnk	126	15	inactive	inactive	JJ
cord-321607-3r736dnk	126	16	ns2	ns2	NNP
cord-321607-3r736dnk	126	17	,	,	,
cord-321607-3r736dnk	126	18	was	be	VBD
cord-321607-3r736dnk	126	19	unable	unable	JJ
cord-321607-3r736dnk	126	20	to	to	TO
cord-321607-3r736dnk	126	21	inactivate	inactivate	VB
cord-321607-3r736dnk	126	22	2	2	CD
cord-321607-3r736dnk	126	23	-	-	HYPH
cord-321607-3r736dnk	126	24	5A	5a	NN
cord-321607-3r736dnk	126	25	and	and	CC
cord-321607-3r736dnk	126	26	inhibit	inhibit	VB
cord-321607-3r736dnk	126	27	RNase	RNase	NNP
cord-321607-3r736dnk	126	28	-	-	HYPH
cord-321607-3r736dnk	126	29	L	l	NN
cord-321607-3r736dnk	126	30	activation	activation	NN
cord-321607-3r736dnk	126	31	,	,	,
cord-321607-3r736dnk	126	32	thus	thus	RB
cord-321607-3r736dnk	126	33	the	the	DT
cord-321607-3r736dnk	126	34	development	development	NN
cord-321607-3r736dnk	126	35	of	of	IN
cord-321607-3r736dnk	126	36	hepatitis	hepatitis	NN
cord-321607-3r736dnk	126	37	and	and	CC
cord-321607-3r736dnk	126	38	replication	replication	NN
cord-321607-3r736dnk	126	39	in	in	IN
cord-321607-3r736dnk	126	40	the	the	DT
cord-321607-3r736dnk	126	41	liver	liver	NN
cord-321607-3r736dnk	126	42	was	be	VBD
cord-321607-3r736dnk	126	43	unimpaired	unimpaired	JJ
cord-321607-3r736dnk	126	44	.	.	.
cord-321607-3r736dnk	127	1	This	this	DT
cord-321607-3r736dnk	127	2	demonstrates	demonstrate	VBZ
cord-321607-3r736dnk	127	3	that	that	IN
cord-321607-3r736dnk	127	4	MHV	MHV	NNP
cord-321607-3r736dnk	127	5	-	-	HYPH
cord-321607-3r736dnk	127	6	ns2	ns2	NNP
cord-321607-3r736dnk	127	7	is	be	VBZ
cord-321607-3r736dnk	127	8	a	a	DT
cord-321607-3r736dnk	127	9	potent	potent	JJ
cord-321607-3r736dnk	127	10	antagonist	antagonist	NN
cord-321607-3r736dnk	127	11	of	of	IN
cord-321607-3r736dnk	127	12	the	the	DT
cord-321607-3r736dnk	127	13	OAS	OAS	NNP
cord-321607-3r736dnk	127	14	/	/	SYM
cord-321607-3r736dnk	127	15	RNase	RNase	NNP
cord-321607-3r736dnk	127	16	-	-	HYPH
cord-321607-3r736dnk	127	17	L	l	NN
cord-321607-3r736dnk	127	18	pathway	pathway	NN
cord-321607-3r736dnk	127	19	[	[	-LRB-
cord-321607-3r736dnk	127	20	99	99	CD
cord-321607-3r736dnk	127	21	]	]	-RRB-
cord-321607-3r736dnk	127	22	.	.	.
cord-321607-3r736dnk	128	1	A	a	DT
cord-321607-3r736dnk	128	2	more	more	RBR
cord-321607-3r736dnk	128	3	detailed	detailed	JJ
cord-321607-3r736dnk	128	4	analysis	analysis	NN
cord-321607-3r736dnk	128	5	of	of	IN
cord-321607-3r736dnk	128	6	these	these	DT
cord-321607-3r736dnk	128	7	and	and	CC
cord-321607-3r736dnk	128	8	other	other	JJ
cord-321607-3r736dnk	128	9	viral	viral	JJ
cord-321607-3r736dnk	128	10	evasion	evasion	NN
cord-321607-3r736dnk	128	11	mechanisms	mechanism	NNS
cord-321607-3r736dnk	128	12	are	be	VBP
cord-321607-3r736dnk	128	13	reviewed	review	VBN
cord-321607-3r736dnk	128	14	by	by	IN
cord-321607-3r736dnk	128	15	Drappier	Drappier	NNP
cord-321607-3r736dnk	128	16	et	et	NNP
cord-321607-3r736dnk	128	17	al	al	NNP
cord-321607-3r736dnk	128	18	.	.	.
cord-321607-3r736dnk	129	1	[	[	-LRB-
cord-321607-3r736dnk	129	2	100	100	CD
cord-321607-3r736dnk	129	3	]	]	-RRB-
cord-321607-3r736dnk	129	4	,	,	,
cord-321607-3r736dnk	129	5	highlighting	highlight	VBG
cord-321607-3r736dnk	129	6	the	the	DT
cord-321607-3r736dnk	129	7	importance	importance	NN
cord-321607-3r736dnk	129	8	of	of	IN
cord-321607-3r736dnk	129	9	RNase	RNase	NNP
cord-321607-3r736dnk	129	10	-	-	HYPH
cord-321607-3r736dnk	129	11	L	L	NNP
cord-321607-3r736dnk	129	12	as	as	IN
cord-321607-3r736dnk	129	13	an	an	DT
cord-321607-3r736dnk	129	14	antiviral	antiviral	JJ
cord-321607-3r736dnk	129	15	effector	effector	NN
cord-321607-3r736dnk	129	16	.	.	.
cord-321607-3r736dnk	130	1	Although	although	IN
cord-321607-3r736dnk	130	2	the	the	DT
cord-321607-3r736dnk	130	3	type	type	NN
cord-321607-3r736dnk	130	4	I	-PRON-	PRP
cord-321607-3r736dnk	130	5	IFNs	ifns	VBP
cord-321607-3r736dnk	130	6	were	be	VBD
cord-321607-3r736dnk	130	7	originally	originally	RB
cord-321607-3r736dnk	130	8	discovered	discover	VBN
cord-321607-3r736dnk	130	9	as	as	IN
cord-321607-3r736dnk	130	10	agents	agent	NNS
cord-321607-3r736dnk	130	11	of	of	IN
cord-321607-3r736dnk	130	12	antiviral	antiviral	JJ
cord-321607-3r736dnk	130	13	activity	activity	NN
cord-321607-3r736dnk	130	14	,	,	,
cord-321607-3r736dnk	130	15	their	-PRON-	PRP$
cord-321607-3r736dnk	130	16	role	role	NN
cord-321607-3r736dnk	130	17	in	in	IN
cord-321607-3r736dnk	130	18	defense	defense	NN
cord-321607-3r736dnk	130	19	against	against	IN
cord-321607-3r736dnk	130	20	other	other	JJ
cord-321607-3r736dnk	130	21	pathogens	pathogen	NNS
cord-321607-3r736dnk	130	22	has	have	VBZ
cord-321607-3r736dnk	130	23	been	be	VBN
cord-321607-3r736dnk	130	24	a	a	DT
cord-321607-3r736dnk	130	25	continually	continually	RB
cord-321607-3r736dnk	130	26	expanding	expand	VBG
cord-321607-3r736dnk	130	27	field	field	NN
cord-321607-3r736dnk	130	28	,	,	,
cord-321607-3r736dnk	130	29	particularly	particularly	RB
cord-321607-3r736dnk	130	30	since	since	IN
cord-321607-3r736dnk	130	31	the	the	DT
cord-321607-3r736dnk	130	32	discovery	discovery	NN
cord-321607-3r736dnk	130	33	of	of	IN
cord-321607-3r736dnk	130	34	the	the	DT
cord-321607-3r736dnk	130	35	TLRs	TLRs	NNPS
cord-321607-3r736dnk	130	36	.	.	.
cord-321607-3r736dnk	131	1	In	in	IN
cord-321607-3r736dnk	131	2	2008	2008	CD
cord-321607-3r736dnk	131	3	,	,	,
cord-321607-3r736dnk	131	4	our	-PRON-	PRP$
cord-321607-3r736dnk	131	5	lab	lab	NN
cord-321607-3r736dnk	131	6	provided	provide	VBD
cord-321607-3r736dnk	131	7	the	the	DT
cord-321607-3r736dnk	131	8	first	first	JJ
cord-321607-3r736dnk	131	9	evidence	evidence	NN
cord-321607-3r736dnk	131	10	of	of	IN
cord-321607-3r736dnk	131	11	antibacterial	antibacterial	JJ
cord-321607-3r736dnk	131	12	activity	activity	NN
cord-321607-3r736dnk	131	13	by	by	IN
cord-321607-3r736dnk	131	14	RNase	RNase	NNP
cord-321607-3r736dnk	131	15	-	-	HYPH
cord-321607-3r736dnk	131	16	L.	L.	NNP
cord-321607-3r736dnk	132	1	We	-PRON-	PRP
cord-321607-3r736dnk	132	2	demonstrated	demonstrate	VBD
cord-321607-3r736dnk	132	3	that	that	IN
cord-321607-3r736dnk	132	4	RNase	RNase	NNP
cord-321607-3r736dnk	132	5	-	-	HYPH
cord-321607-3r736dnk	132	6	L	L	NNP
cord-321607-3r736dnk	132	7	KO	KO	NNP
cord-321607-3r736dnk	132	8	mice	mouse	NNS
cord-321607-3r736dnk	132	9	are	be	VBP
cord-321607-3r736dnk	132	10	more	more	RBR
cord-321607-3r736dnk	132	11	susceptible	susceptible	JJ
cord-321607-3r736dnk	132	12	to	to	IN
cord-321607-3r736dnk	132	13	sublethal	sublethal	JJ
cord-321607-3r736dnk	132	14	infection	infection	NN
cord-321607-3r736dnk	132	15	by	by	IN
cord-321607-3r736dnk	132	16	both	both	DT
cord-321607-3r736dnk	132	17	Escherichia	Escherichia	NNP
cord-321607-3r736dnk	132	18	coli	coli	NNS
cord-321607-3r736dnk	132	19	(	(	-LRB-
cord-321607-3r736dnk	132	20	E.	E.	NNP
cord-321607-3r736dnk	132	21	coli	coli	NNS
cord-321607-3r736dnk	132	22	)	)	-RRB-
cord-321607-3r736dnk	132	23	and	and	CC
cord-321607-3r736dnk	132	24	Bacillus	Bacillus	NNP
cord-321607-3r736dnk	132	25	anthracis	anthracis	NN
cord-321607-3r736dnk	132	26	(	(	-LRB-
cord-321607-3r736dnk	132	27	BA	BA	NNP
cord-321607-3r736dnk	132	28	)	)	-RRB-
cord-321607-3r736dnk	132	29	than	than	IN
cord-321607-3r736dnk	132	30	WT	WT	NNP
cord-321607-3r736dnk	132	31	mice	mouse	NNS
cord-321607-3r736dnk	132	32	.	.	.
cord-321607-3r736dnk	133	1	Multiple	multiple	JJ
cord-321607-3r736dnk	133	2	mechanisms	mechanism	NNS
cord-321607-3r736dnk	133	3	were	be	VBD
cord-321607-3r736dnk	133	4	found	find	VBN
cord-321607-3r736dnk	133	5	to	to	TO
cord-321607-3r736dnk	133	6	contribute	contribute	VB
cord-321607-3r736dnk	133	7	to	to	IN
cord-321607-3r736dnk	133	8	this	this	DT
cord-321607-3r736dnk	133	9	sensitivity	sensitivity	NN
cord-321607-3r736dnk	133	10	,	,	,
cord-321607-3r736dnk	133	11	including	include	VBG
cord-321607-3r736dnk	133	12	changes	change	NNS
cord-321607-3r736dnk	133	13	in	in	IN
cord-321607-3r736dnk	133	14	gene	gene	NN
cord-321607-3r736dnk	133	15	regulation	regulation	NN
cord-321607-3r736dnk	133	16	that	that	WDT
cord-321607-3r736dnk	133	17	likely	likely	RB
cord-321607-3r736dnk	133	18	contributed	contribute	VBD
cord-321607-3r736dnk	133	19	to	to	TO
cord-321607-3r736dnk	133	20	immune	immune	JJ
cord-321607-3r736dnk	133	21	cell	cell	NN
cord-321607-3r736dnk	133	22	dysfunction	dysfunction	NN
cord-321607-3r736dnk	133	23	.	.	.
cord-321607-3r736dnk	134	1	Specifically	specifically	RB
cord-321607-3r736dnk	134	2	,	,	,
cord-321607-3r736dnk	134	3	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	134	4	,	,	,
cord-321607-3r736dnk	134	5	the	the	DT
cord-321607-3r736dnk	134	6	proinflammatory	proinflammatory	JJ
cord-321607-3r736dnk	134	7	cytokines	cytokine	NNS
cord-321607-3r736dnk	134	8	tumor	tumor	NN
cord-321607-3r736dnk	134	9	necrosis	necrosis	NN
cord-321607-3r736dnk	134	10	factor	factor	NN
cord-321607-3r736dnk	134	11	-	-	HYPH
cord-321607-3r736dnk	134	12	α	α	NN
cord-321607-3r736dnk	134	13	(	(	-LRB-
cord-321607-3r736dnk	134	14	TNFα	TNFα	NNP
cord-321607-3r736dnk	134	15	)	)	-RRB-
cord-321607-3r736dnk	134	16	and	and	CC
cord-321607-3r736dnk	134	17	interleukin-1β	interleukin-1β	NNP
cord-321607-3r736dnk	134	18	(	(	-LRB-
cord-321607-3r736dnk	134	19	IL-1β	IL-1β	NNP
cord-321607-3r736dnk	134	20	)	)	-RRB-
cord-321607-3r736dnk	134	21	,	,	,
cord-321607-3r736dnk	134	22	and	and	CC
cord-321607-3r736dnk	134	23	a	a	DT
cord-321607-3r736dnk	134	24	protease	protease	NN
cord-321607-3r736dnk	134	25	involved	involve	VBN
cord-321607-3r736dnk	134	26	in	in	IN
cord-321607-3r736dnk	134	27	endolysosomal	endolysosomal	JJ
cord-321607-3r736dnk	134	28	maturation	maturation	NN
cord-321607-3r736dnk	134	29	,	,	,
cord-321607-3r736dnk	134	30	cathepsin	cathepsin	NN
cord-321607-3r736dnk	134	31	E	e	NN
cord-321607-3r736dnk	134	32	,	,	,
cord-321607-3r736dnk	134	33	were	be	VBD
cord-321607-3r736dnk	134	34	all	all	DT
cord-321607-3r736dnk	134	35	dysregulated	dysregulate	VBN
cord-321607-3r736dnk	134	36	in	in	IN
cord-321607-3r736dnk	134	37	RNase	RNase	NNP
cord-321607-3r736dnk	134	38	-	-	HYPH
cord-321607-3r736dnk	134	39	L	L	NNP
cord-321607-3r736dnk	134	40	KO	KO	NNP
cord-321607-3r736dnk	134	41	mice	mouse	NNS
cord-321607-3r736dnk	134	42	and	and	CC
cord-321607-3r736dnk	134	43	purified	purify	VBN
cord-321607-3r736dnk	134	44	peritoneal	peritoneal	JJ
cord-321607-3r736dnk	134	45	macrophages	macrophage	NNS
cord-321607-3r736dnk	134	46	.	.	.
cord-321607-3r736dnk	135	1	This	this	DT
cord-321607-3r736dnk	135	2	likely	likely	RB
cord-321607-3r736dnk	135	3	contributed	contribute	VBD
cord-321607-3r736dnk	135	4	to	to	IN
cord-321607-3r736dnk	135	5	the	the	DT
cord-321607-3r736dnk	135	6	decreased	decreased	JJ
cord-321607-3r736dnk	135	7	bactericidal	bactericidal	JJ
cord-321607-3r736dnk	135	8	activity	activity	NN
cord-321607-3r736dnk	135	9	observed	observe	VBN
cord-321607-3r736dnk	135	10	in	in	IN
cord-321607-3r736dnk	135	11	infected	infected	JJ
cord-321607-3r736dnk	135	12	macrophages	macrophage	NNS
cord-321607-3r736dnk	135	13	,	,	,
cord-321607-3r736dnk	135	14	altered	alter	VBN
cord-321607-3r736dnk	135	15	macrophage	macrophage	NN
cord-321607-3r736dnk	135	16	maturation	maturation	NN
cord-321607-3r736dnk	135	17	,	,	,
cord-321607-3r736dnk	135	18	and	and	CC
cord-321607-3r736dnk	135	19	differences	difference	NNS
cord-321607-3r736dnk	135	20	in	in	IN
cord-321607-3r736dnk	135	21	neutrophil	neutrophil	NN
cord-321607-3r736dnk	135	22	and	and	CC
cord-321607-3r736dnk	135	23	lymphocyte	lymphocyte	NN
cord-321607-3r736dnk	135	24	recruitment	recruitment	NN
cord-321607-3r736dnk	135	25	.	.	.
cord-321607-3r736dnk	136	1	These	these	DT
cord-321607-3r736dnk	136	2	changes	change	NNS
cord-321607-3r736dnk	136	3	in	in	IN
cord-321607-3r736dnk	136	4	proinflammatory	proinflammatory	JJ
cord-321607-3r736dnk	136	5	gene	gene	NN
cord-321607-3r736dnk	136	6	expression	expression	NN
cord-321607-3r736dnk	136	7	were	be	VBD
cord-321607-3r736dnk	136	8	also	also	RB
cord-321607-3r736dnk	136	9	seen	see	VBN
cord-321607-3r736dnk	136	10	in	in	IN
cord-321607-3r736dnk	136	11	response	response	NN
cord-321607-3r736dnk	136	12	to	to	IN
cord-321607-3r736dnk	136	13	dsRNA	dsrna	NN
cord-321607-3r736dnk	136	14	,	,	,
cord-321607-3r736dnk	136	15	lipopolysaccharide	lipopolysaccharide	NN
cord-321607-3r736dnk	136	16	,	,	,
cord-321607-3r736dnk	136	17	and	and	CC
cord-321607-3r736dnk	136	18	CpG	CpG	NNP
cord-321607-3r736dnk	136	19	DNA	DNA	NNP
cord-321607-3r736dnk	136	20	stimulation	stimulation	NN
cord-321607-3r736dnk	136	21	of	of	IN
cord-321607-3r736dnk	136	22	TLRs	TLRs	NNP
cord-321607-3r736dnk	136	23	3	3	CD
cord-321607-3r736dnk	136	24	,	,	,
cord-321607-3r736dnk	136	25	4	4	CD
cord-321607-3r736dnk	136	26	,	,	,
cord-321607-3r736dnk	136	27	and	and	CC
cord-321607-3r736dnk	136	28	9	9	CD
cord-321607-3r736dnk	136	29	,	,	,
cord-321607-3r736dnk	136	30	respectively	respectively	RB
cord-321607-3r736dnk	136	31	[	[	-LRB-
cord-321607-3r736dnk	136	32	26	26	CD
cord-321607-3r736dnk	136	33	]	]	-RRB-
cord-321607-3r736dnk	136	34	.	.	.
cord-321607-3r736dnk	137	1	On	on	IN
cord-321607-3r736dnk	137	2	the	the	DT
cord-321607-3r736dnk	137	3	heels	heel	NNS
cord-321607-3r736dnk	137	4	of	of	IN
cord-321607-3r736dnk	137	5	this	this	DT
cord-321607-3r736dnk	137	6	work	work	NN
cord-321607-3r736dnk	137	7	,	,	,
cord-321607-3r736dnk	137	8	it	-PRON-	PRP
cord-321607-3r736dnk	137	9	was	be	VBD
cord-321607-3r736dnk	137	10	discovered	discover	VBN
cord-321607-3r736dnk	137	11	that	that	IN
cord-321607-3r736dnk	137	12	E.	E.	NNP
cord-321607-3r736dnk	137	13	coli	coli	NNP
cord-321607-3r736dnk	137	14	RNA	RNA	NNP
cord-321607-3r736dnk	137	15	could	could	MD
cord-321607-3r736dnk	137	16	activate	activate	VB
cord-321607-3r736dnk	137	17	RNase	RNase	NNP
cord-321607-3r736dnk	137	18	-	-	HYPH
cord-321607-3r736dnk	137	19	L	l	NN
cord-321607-3r736dnk	137	20	induction	induction	NN
cord-321607-3r736dnk	137	21	of	of	IN
cord-321607-3r736dnk	137	22	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	137	23	and	and	CC
cord-321607-3r736dnk	137	24	that	that	IN
cord-321607-3r736dnk	137	25	RNase	RNase	NNP
cord-321607-3r736dnk	137	26	-	-	HYPH
cord-321607-3r736dnk	137	27	L	L	NNP
cord-321607-3r736dnk	137	28	also	also	RB
cord-321607-3r736dnk	137	29	plays	play	VBZ
cord-321607-3r736dnk	137	30	an	an	DT
cord-321607-3r736dnk	137	31	important	important	JJ
cord-321607-3r736dnk	137	32	part	part	NN
cord-321607-3r736dnk	137	33	in	in	IN
cord-321607-3r736dnk	137	34	gut	gut	NN
cord-321607-3r736dnk	137	35	immunity	immunity	NN
cord-321607-3r736dnk	137	36	[	[	-LRB-
cord-321607-3r736dnk	137	37	23	23	CD
cord-321607-3r736dnk	137	38	]	]	-RRB-
cord-321607-3r736dnk	137	39	.	.	.
cord-321607-3r736dnk	138	1	Therefore	therefore	RB
cord-321607-3r736dnk	138	2	,	,	,
cord-321607-3r736dnk	138	3	our	-PRON-	PRP$
cord-321607-3r736dnk	138	4	lab	lab	NN
cord-321607-3r736dnk	138	5	investigated	investigate	VBD
cord-321607-3r736dnk	138	6	the	the	DT
cord-321607-3r736dnk	138	7	role	role	NN
cord-321607-3r736dnk	138	8	of	of	IN
cord-321607-3r736dnk	138	9	RNase	RNase	NNP
cord-321607-3r736dnk	138	10	-	-	HYPH
cord-321607-3r736dnk	138	11	L	l	NN
cord-321607-3r736dnk	138	12	in	in	IN
cord-321607-3r736dnk	138	13	the	the	DT
cord-321607-3r736dnk	138	14	pathogenesis	pathogenesis	NN
cord-321607-3r736dnk	138	15	of	of	IN
cord-321607-3r736dnk	138	16	the	the	DT
cord-321607-3r736dnk	138	17	intestinal	intestinal	JJ
cord-321607-3r736dnk	138	18	pathogen	pathogen	NN
cord-321607-3r736dnk	138	19	enteropathogenic	enteropathogenic	JJ
cord-321607-3r736dnk	138	20	E.	E.	NNP
cord-321607-3r736dnk	138	21	coli	coli	NNS
cord-321607-3r736dnk	138	22	(	(	-LRB-
cord-321607-3r736dnk	138	23	EPEC	EPEC	NNP
cord-321607-3r736dnk	138	24	)	)	-RRB-
cord-321607-3r736dnk	138	25	.	.	.
cord-321607-3r736dnk	139	1	In	in	IN
cord-321607-3r736dnk	139	2	a	a	DT
cord-321607-3r736dnk	139	3	novel	novel	JJ
cord-321607-3r736dnk	139	4	antimicrobial	antimicrobial	JJ
cord-321607-3r736dnk	139	5	role	role	NN
cord-321607-3r736dnk	139	6	for	for	IN
cord-321607-3r736dnk	139	7	RNase	RNase	NNP
cord-321607-3r736dnk	139	8	-	-	HYPH
cord-321607-3r736dnk	139	9	L	L	NNP
cord-321607-3r736dnk	139	10	,	,	,
cord-321607-3r736dnk	139	11	we	-PRON-	PRP
cord-321607-3r736dnk	139	12	found	find	VBD
cord-321607-3r736dnk	139	13	that	that	IN
cord-321607-3r736dnk	139	14	it	-PRON-	PRP
cord-321607-3r736dnk	139	15	helps	help	VBZ
cord-321607-3r736dnk	139	16	maintain	maintain	VB
cord-321607-3r736dnk	139	17	the	the	DT
cord-321607-3r736dnk	139	18	intercellular	intercellular	JJ
cord-321607-3r736dnk	139	19	barrier	barrier	NN
cord-321607-3r736dnk	139	20	formed	form	VBN
cord-321607-3r736dnk	139	21	by	by	IN
cord-321607-3r736dnk	139	22	intestinal	intestinal	JJ
cord-321607-3r736dnk	139	23	epithelial	epithelial	JJ
cord-321607-3r736dnk	139	24	cell	cell	NN
cord-321607-3r736dnk	139	25	(	(	-LRB-
cord-321607-3r736dnk	139	26	IEC	IEC	NNP
cord-321607-3r736dnk	139	27	)	)	-RRB-
cord-321607-3r736dnk	139	28	monolayers	monolayer	NNS
cord-321607-3r736dnk	139	29	,	,	,
cord-321607-3r736dnk	139	30	preventing	prevent	VBG
cord-321607-3r736dnk	139	31	pathogen	pathogen	NN
cord-321607-3r736dnk	139	32	translocation	translocation	NN
cord-321607-3r736dnk	139	33	from	from	IN
cord-321607-3r736dnk	139	34	the	the	DT
cord-321607-3r736dnk	139	35	gut	gut	NN
cord-321607-3r736dnk	139	36	into	into	IN
cord-321607-3r736dnk	139	37	the	the	DT
cord-321607-3r736dnk	139	38	host	host	NN
cord-321607-3r736dnk	139	39	.	.	.
cord-321607-3r736dnk	140	1	Similar	similar	JJ
cord-321607-3r736dnk	140	2	to	to	IN
cord-321607-3r736dnk	140	3	our	-PRON-	PRP$
cord-321607-3r736dnk	140	4	previous	previous	JJ
cord-321607-3r736dnk	140	5	studies	study	NNS
cord-321607-3r736dnk	140	6	,	,	,
cord-321607-3r736dnk	140	7	we	-PRON-	PRP
cord-321607-3r736dnk	140	8	also	also	RB
cord-321607-3r736dnk	140	9	saw	see	VBD
cord-321607-3r736dnk	140	10	dysregulation	dysregulation	NN
cord-321607-3r736dnk	140	11	of	of	IN
cord-321607-3r736dnk	140	12	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	140	13	and	and	CC
cord-321607-3r736dnk	140	14	TNFα	TNFα	NNS
cord-321607-3r736dnk	140	15	as	as	RB
cord-321607-3r736dnk	140	16	well	well	RB
cord-321607-3r736dnk	140	17	as	as	IN
cord-321607-3r736dnk	140	18	novel	novel	JJ
cord-321607-3r736dnk	140	19	regulation	regulation	NN
cord-321607-3r736dnk	140	20	of	of	IN
cord-321607-3r736dnk	140	21	the	the	DT
cord-321607-3r736dnk	140	22	tight	tight	JJ
cord-321607-3r736dnk	140	23	junction	junction	NN
cord-321607-3r736dnk	140	24	proteins	protein	NNS
cord-321607-3r736dnk	140	25	occludin	occludin	NNP
cord-321607-3r736dnk	140	26	and	and	CC
cord-321607-3r736dnk	140	27	claudin-1	claudin-1	NNP
cord-321607-3r736dnk	140	28	,	,	,
cord-321607-3r736dnk	140	29	which	which	WDT
cord-321607-3r736dnk	140	30	undoubtedly	undoubtedly	RB
cord-321607-3r736dnk	140	31	contributed	contribute	VBD
cord-321607-3r736dnk	140	32	to	to	IN
cord-321607-3r736dnk	140	33	the	the	DT
cord-321607-3r736dnk	140	34	defects	defect	NNS
cord-321607-3r736dnk	140	35	in	in	IN
cord-321607-3r736dnk	140	36	barrier	barrier	NN
cord-321607-3r736dnk	140	37	function	function	NN
cord-321607-3r736dnk	140	38	[	[	-LRB-
cord-321607-3r736dnk	140	39	84	84	CD
cord-321607-3r736dnk	140	40	]	]	-RRB-
cord-321607-3r736dnk	140	41	.	.	.
cord-321607-3r736dnk	141	1	Many	many	JJ
cord-321607-3r736dnk	141	2	types	type	NNS
cord-321607-3r736dnk	141	3	of	of	IN
cord-321607-3r736dnk	141	4	bacteria	bacteria	NNS
cord-321607-3r736dnk	141	5	may	may	MD
cord-321607-3r736dnk	141	6	activate	activate	VB
cord-321607-3r736dnk	141	7	RNase	RNase	NNP
cord-321607-3r736dnk	141	8	-	-	HYPH
cord-321607-3r736dnk	141	9	L	l	NN
cord-321607-3r736dnk	141	10	through	through	IN
cord-321607-3r736dnk	141	11	endocytosis	endocytosis	NN
cord-321607-3r736dnk	141	12	and	and	CC
cord-321607-3r736dnk	141	13	either	either	DT
cord-321607-3r736dnk	141	14	escape	escape	NN
cord-321607-3r736dnk	141	15	of	of	IN
cord-321607-3r736dnk	141	16	the	the	DT
cord-321607-3r736dnk	141	17	bacterium	bacterium	NN
cord-321607-3r736dnk	141	18	or	or	CC
cord-321607-3r736dnk	141	19	leakage	leakage	NN
cord-321607-3r736dnk	141	20	of	of	IN
cord-321607-3r736dnk	141	21	RNA	RNA	NNP
cord-321607-3r736dnk	141	22	into	into	IN
cord-321607-3r736dnk	141	23	the	the	DT
cord-321607-3r736dnk	141	24	cytosol	cytosol	NN
cord-321607-3r736dnk	141	25	during	during	IN
cord-321607-3r736dnk	141	26	infection	infection	NN
cord-321607-3r736dnk	141	27	.	.	.
cord-321607-3r736dnk	142	1	However	however	RB
cord-321607-3r736dnk	142	2	,	,	,
cord-321607-3r736dnk	142	3	since	since	IN
cord-321607-3r736dnk	142	4	RNA	RNA	NNP
cord-321607-3r736dnk	142	5	in	in	IN
cord-321607-3r736dnk	142	6	actively	actively	RB
cord-321607-3r736dnk	142	7	replicating	replicate	VBG
cord-321607-3r736dnk	142	8	bacteria	bacteria	NNS
cord-321607-3r736dnk	142	9	is	be	VBZ
cord-321607-3r736dnk	142	10	not	not	RB
cord-321607-3r736dnk	142	11	exposed	expose	VBN
cord-321607-3r736dnk	142	12	to	to	IN
cord-321607-3r736dnk	142	13	cytosolic	cytosolic	JJ
cord-321607-3r736dnk	142	14	RNase	RNase	NNP
cord-321607-3r736dnk	142	15	-	-	HYPH
cord-321607-3r736dnk	142	16	L	L	NNP
cord-321607-3r736dnk	142	17	,	,	,
cord-321607-3r736dnk	142	18	it	-PRON-	PRP
cord-321607-3r736dnk	142	19	is	be	VBZ
cord-321607-3r736dnk	142	20	likely	likely	RB
cord-321607-3r736dnk	142	21	resistant	resistant	JJ
cord-321607-3r736dnk	142	22	to	to	IN
cord-321607-3r736dnk	142	23	direct	direct	JJ
cord-321607-3r736dnk	142	24	cleavage	cleavage	NN
cord-321607-3r736dnk	142	25	as	as	IN
cord-321607-3r736dnk	142	26	an	an	DT
cord-321607-3r736dnk	142	27	effector	effector	NN
cord-321607-3r736dnk	142	28	mechanism	mechanism	NN
cord-321607-3r736dnk	142	29	.	.	.
cord-321607-3r736dnk	143	1	Therefore	therefore	RB
cord-321607-3r736dnk	143	2	,	,	,
cord-321607-3r736dnk	143	3	as	as	IN
cord-321607-3r736dnk	143	4	touched	touch	VBN
cord-321607-3r736dnk	143	5	on	on	IN
cord-321607-3r736dnk	143	6	above	above	RB
cord-321607-3r736dnk	143	7	,	,	,
cord-321607-3r736dnk	143	8	many	many	JJ
cord-321607-3r736dnk	143	9	of	of	IN
cord-321607-3r736dnk	143	10	the	the	DT
cord-321607-3r736dnk	143	11	other	other	JJ
cord-321607-3r736dnk	143	12	antimicrobial	antimicrobial	JJ
cord-321607-3r736dnk	143	13	functions	function	NNS
cord-321607-3r736dnk	143	14	of	of	IN
cord-321607-3r736dnk	143	15	RNase	RNase	NNP
cord-321607-3r736dnk	143	16	-	-	HYPH
cord-321607-3r736dnk	143	17	L	L	NNP
cord-321607-3r736dnk	143	18	may	may	MD
cord-321607-3r736dnk	143	19	be	be	VB
cord-321607-3r736dnk	143	20	more	more	RBR
cord-321607-3r736dnk	143	21	prominent	prominent	JJ
cord-321607-3r736dnk	143	22	in	in	IN
cord-321607-3r736dnk	143	23	these	these	DT
cord-321607-3r736dnk	143	24	types	type	NNS
cord-321607-3r736dnk	143	25	of	of	IN
cord-321607-3r736dnk	143	26	infections	infection	NNS
cord-321607-3r736dnk	143	27	.	.	.
cord-321607-3r736dnk	144	1	As	as	IN
cord-321607-3r736dnk	144	2	exemplified	exemplify	VBN
cord-321607-3r736dnk	144	3	by	by	IN
cord-321607-3r736dnk	144	4	the	the	DT
cord-321607-3r736dnk	144	5	examples	example	NNS
cord-321607-3r736dnk	144	6	of	of	IN
cord-321607-3r736dnk	144	7	antibacterial	antibacterial	JJ
cord-321607-3r736dnk	144	8	activity	activity	NN
cord-321607-3r736dnk	144	9	,	,	,
cord-321607-3r736dnk	144	10	RNase	RNase	NNP
cord-321607-3r736dnk	144	11	-	-	HYPH
cord-321607-3r736dnk	144	12	L	L	NNP
cord-321607-3r736dnk	144	13	utilizes	utilize	VBZ
cord-321607-3r736dnk	144	14	a	a	DT
cord-321607-3r736dnk	144	15	variety	variety	NN
cord-321607-3r736dnk	144	16	of	of	IN
cord-321607-3r736dnk	144	17	mechanisms	mechanism	NNS
cord-321607-3r736dnk	144	18	to	to	TO
cord-321607-3r736dnk	144	19	combat	combat	VB
cord-321607-3r736dnk	144	20	microbial	microbial	JJ
cord-321607-3r736dnk	144	21	infections	infection	NNS
cord-321607-3r736dnk	144	22	.	.	.
cord-321607-3r736dnk	145	1	Early	early	JJ
cord-321607-3r736dnk	145	2	investigations	investigation	NNS
cord-321607-3r736dnk	145	3	into	into	IN
cord-321607-3r736dnk	145	4	antiviral	antiviral	JJ
cord-321607-3r736dnk	145	5	activity	activity	NN
cord-321607-3r736dnk	145	6	focused	focus	VBN
cord-321607-3r736dnk	145	7	on	on	IN
cord-321607-3r736dnk	145	8	direct	direct	JJ
cord-321607-3r736dnk	145	9	cause	cause	NN
cord-321607-3r736dnk	145	10	-	-	HYPH
cord-321607-3r736dnk	145	11	and	and	CC
cord-321607-3r736dnk	145	12	-	-	HYPH
cord-321607-3r736dnk	145	13	effect	effect	NN
cord-321607-3r736dnk	145	14	events	event	NNS
cord-321607-3r736dnk	145	15	such	such	JJ
cord-321607-3r736dnk	145	16	as	as	IN
cord-321607-3r736dnk	145	17	RNase	RNase	NNP
cord-321607-3r736dnk	145	18	-	-	HYPH
cord-321607-3r736dnk	145	19	L	l	NN
cord-321607-3r736dnk	145	20	activation	activation	NN
cord-321607-3r736dnk	145	21	and	and	CC
cord-321607-3r736dnk	145	22	virus	virus	NN
cord-321607-3r736dnk	145	23	genome	genome	NN
cord-321607-3r736dnk	145	24	cleavage	cleavage	NN
cord-321607-3r736dnk	145	25	to	to	TO
cord-321607-3r736dnk	145	26	inhibit	inhibit	VB
cord-321607-3r736dnk	145	27	replication	replication	NN
cord-321607-3r736dnk	145	28	.	.	.
cord-321607-3r736dnk	146	1	The	the	DT
cord-321607-3r736dnk	146	2	expansion	expansion	NN
cord-321607-3r736dnk	146	3	of	of	IN
cord-321607-3r736dnk	146	4	studies	study	NNS
cord-321607-3r736dnk	146	5	into	into	IN
cord-321607-3r736dnk	146	6	DNA	dna	NN
cord-321607-3r736dnk	146	7	viruses	virus	NNS
cord-321607-3r736dnk	147	1	and	and	CC
cord-321607-3r736dnk	147	2	then	then	RB
cord-321607-3r736dnk	147	3	bacteria	bacteria	NNS
cord-321607-3r736dnk	147	4	have	have	VBP
cord-321607-3r736dnk	147	5	corresponded	correspond	VBN
cord-321607-3r736dnk	147	6	with	with	IN
cord-321607-3r736dnk	147	7	broadening	broaden	VBG
cord-321607-3r736dnk	147	8	ideas	idea	NNS
cord-321607-3r736dnk	147	9	in	in	IN
cord-321607-3r736dnk	147	10	the	the	DT
cord-321607-3r736dnk	147	11	field	field	NN
cord-321607-3r736dnk	147	12	about	about	IN
cord-321607-3r736dnk	147	13	RNase	RNase	NNP
cord-321607-3r736dnk	147	14	-	-	HYPH
cord-321607-3r736dnk	147	15	L	l	NN
cord-321607-3r736dnk	147	16	functions	function	NNS
cord-321607-3r736dnk	147	17	via	via	IN
cord-321607-3r736dnk	147	18	more	more	JJR
cord-321607-3r736dnk	147	19	indirect	indirect	JJ
cord-321607-3r736dnk	147	20	antimicrobial	antimicrobial	JJ
cord-321607-3r736dnk	147	21	activities	activity	NNS
cord-321607-3r736dnk	147	22	,	,	,
cord-321607-3r736dnk	147	23	including	include	VBG
cord-321607-3r736dnk	147	24	apoptosis	apoptosis	NN
cord-321607-3r736dnk	147	25	,	,	,
cord-321607-3r736dnk	147	26	immune	immune	JJ
cord-321607-3r736dnk	147	27	modulation	modulation	NN
cord-321607-3r736dnk	147	28	,	,	,
cord-321607-3r736dnk	147	29	gene	gene	NN
cord-321607-3r736dnk	147	30	regulation	regulation	NN
cord-321607-3r736dnk	147	31	,	,	,
cord-321607-3r736dnk	147	32	autophagy	autophagy	NN
cord-321607-3r736dnk	147	33	,	,	,
cord-321607-3r736dnk	147	34	and	and	CC
cord-321607-3r736dnk	147	35	structural	structural	JJ
cord-321607-3r736dnk	147	36	integrity	integrity	NN
cord-321607-3r736dnk	147	37	.	.	.
cord-321607-3r736dnk	148	1	One	one	CD
cord-321607-3r736dnk	148	2	of	of	IN
cord-321607-3r736dnk	148	3	the	the	DT
cord-321607-3r736dnk	148	4	first	first	JJ
cord-321607-3r736dnk	148	5	alternative	alternative	JJ
cord-321607-3r736dnk	148	6	mechanisms	mechanism	NNS
cord-321607-3r736dnk	148	7	was	be	VBD
cord-321607-3r736dnk	148	8	elucidated	elucidate	VBN
cord-321607-3r736dnk	148	9	by	by	IN
cord-321607-3r736dnk	148	10	Castelli	Castelli	NNP
cord-321607-3r736dnk	148	11	et	et	NNP
cord-321607-3r736dnk	148	12	al	al	NNP
cord-321607-3r736dnk	148	13	.	.	.
cord-321607-3r736dnk	149	1	[	[	-LRB-
cord-321607-3r736dnk	149	2	12	12	CD
cord-321607-3r736dnk	149	3	,	,	,
cord-321607-3r736dnk	149	4	13	13	CD
cord-321607-3r736dnk	149	5	]	]	-RRB-
cord-321607-3r736dnk	149	6	,	,	,
cord-321607-3r736dnk	149	7	who	who	WP
cord-321607-3r736dnk	149	8	demonstrated	demonstrate	VBD
cord-321607-3r736dnk	149	9	that	that	IN
cord-321607-3r736dnk	149	10	RNase	RNase	NNP
cord-321607-3r736dnk	149	11	-	-	HYPH
cord-321607-3r736dnk	149	12	L	l	NN
cord-321607-3r736dnk	149	13	mediated	mediate	VBN
cord-321607-3r736dnk	149	14	apoptosis	apoptosis	NN
cord-321607-3r736dnk	149	15	in	in	IN
cord-321607-3r736dnk	149	16	response	response	NN
cord-321607-3r736dnk	149	17	to	to	IN
cord-321607-3r736dnk	149	18	activation	activation	NN
cord-321607-3r736dnk	149	19	by	by	IN
cord-321607-3r736dnk	149	20	virus	virus	NN
cord-321607-3r736dnk	149	21	infection	infection	NN
cord-321607-3r736dnk	149	22	or	or	CC
cord-321607-3r736dnk	149	23	dsRNA	dsrna	NN
cord-321607-3r736dnk	149	24	.	.	.
cord-321607-3r736dnk	150	1	Zhou	Zhou	NNP
cord-321607-3r736dnk	150	2	et	et	NNP
cord-321607-3r736dnk	150	3	al	al	NNP
cord-321607-3r736dnk	150	4	.	.	.
cord-321607-3r736dnk	151	1	[	[	-LRB-
cord-321607-3r736dnk	151	2	15	15	CD
cord-321607-3r736dnk	151	3	]	]	-RRB-
cord-321607-3r736dnk	151	4	confirmed	confirm	VBD
cord-321607-3r736dnk	151	5	this	this	DT
cord-321607-3r736dnk	151	6	role	role	NN
cord-321607-3r736dnk	151	7	for	for	IN
cord-321607-3r736dnk	151	8	RNase	RNase	NNP
cord-321607-3r736dnk	151	9	-	-	HYPH
cord-321607-3r736dnk	151	10	L	L	NNP
cord-321607-3r736dnk	151	11	in	in	IN
cord-321607-3r736dnk	151	12	Fas	Fas	NNP
cord-321607-3r736dnk	151	13	,	,	,
cord-321607-3r736dnk	151	14	TNFα	TNFα	NNP
cord-321607-3r736dnk	151	15	,	,	,
cord-321607-3r736dnk	151	16	and	and	CC
cord-321607-3r736dnk	151	17	α	α	NNP
cord-321607-3r736dnk	151	18	-	-	HYPH
cord-321607-3r736dnk	151	19	CD3	CD3	NNP
cord-321607-3r736dnk	151	20	antibody	antibody	NN
cord-321607-3r736dnk	151	21	-	-	HYPH
cord-321607-3r736dnk	151	22	induced	induce	VBN
cord-321607-3r736dnk	151	23	apoptosis	apoptosis	NN
cord-321607-3r736dnk	151	24	.	.	.
cord-321607-3r736dnk	152	1	Further	further	JJ
cord-321607-3r736dnk	152	2	characterization	characterization	NN
cord-321607-3r736dnk	152	3	showed	show	VBD
cord-321607-3r736dnk	152	4	that	that	IN
cord-321607-3r736dnk	152	5	RNase	RNase	NNP
cord-321607-3r736dnk	152	6	-	-	HYPH
cord-321607-3r736dnk	152	7	L	l	NN
cord-321607-3r736dnk	152	8	-	-	HYPH
cord-321607-3r736dnk	152	9	dependent	dependent	JJ
cord-321607-3r736dnk	152	10	cell	cell	NN
cord-321607-3r736dnk	152	11	death	death	NN
cord-321607-3r736dnk	152	12	resulted	result	VBD
cord-321607-3r736dnk	152	13	in	in	IN
cord-321607-3r736dnk	152	14	the	the	DT
cord-321607-3r736dnk	152	15	release	release	NN
cord-321607-3r736dnk	152	16	of	of	IN
cord-321607-3r736dnk	152	17	cytochrome	cytochrome	NN
cord-321607-3r736dnk	152	18	c	c	NN
cord-321607-3r736dnk	152	19	from	from	IN
cord-321607-3r736dnk	152	20	the	the	DT
cord-321607-3r736dnk	152	21	mitochondria	mitochondrion	NNS
cord-321607-3r736dnk	152	22	and	and	CC
cord-321607-3r736dnk	152	23	required	require	VBD
cord-321607-3r736dnk	152	24	caspase-3	caspase-3	NNP
cord-321607-3r736dnk	152	25	activation	activation	NN
cord-321607-3r736dnk	152	26	[	[	-LRB-
cord-321607-3r736dnk	152	27	101	101	CD
cord-321607-3r736dnk	152	28	]	]	-RRB-
cord-321607-3r736dnk	152	29	.	.	.
cord-321607-3r736dnk	153	1	This	this	DT
cord-321607-3r736dnk	153	2	early	early	JJ
cord-321607-3r736dnk	153	3	described	describe	VBN
cord-321607-3r736dnk	153	4	role	role	NN
cord-321607-3r736dnk	153	5	for	for	IN
cord-321607-3r736dnk	153	6	RNase	RNase	NNP
cord-321607-3r736dnk	153	7	-	-	HYPH
cord-321607-3r736dnk	153	8	L	L	NNP
cord-321607-3r736dnk	153	9	may	may	MD
cord-321607-3r736dnk	153	10	be	be	VB
cord-321607-3r736dnk	153	11	partially	partially	RB
cord-321607-3r736dnk	153	12	coordinated	coordinate	VBN
cord-321607-3r736dnk	153	13	with	with	IN
cord-321607-3r736dnk	153	14	a	a	DT
cord-321607-3r736dnk	153	15	newly	newly	RB
cord-321607-3r736dnk	153	16	discovered	discover	VBN
cord-321607-3r736dnk	153	17	function	function	NN
cord-321607-3r736dnk	153	18	in	in	IN
cord-321607-3r736dnk	153	19	the	the	DT
cord-321607-3r736dnk	153	20	induction	induction	NN
cord-321607-3r736dnk	153	21	of	of	IN
cord-321607-3r736dnk	153	22	autophagy	autophagy	NN
cord-321607-3r736dnk	153	23	.	.	.
cord-321607-3r736dnk	154	1	Autophagy	Autophagy	NNP
cord-321607-3r736dnk	154	2	is	be	VBZ
cord-321607-3r736dnk	154	3	a	a	DT
cord-321607-3r736dnk	154	4	stress	stress	NN
cord-321607-3r736dnk	154	5	response	response	NN
cord-321607-3r736dnk	154	6	that	that	WDT
cord-321607-3r736dnk	154	7	induces	induce	VBZ
cord-321607-3r736dnk	154	8	the	the	DT
cord-321607-3r736dnk	154	9	recycling	recycling	NN
cord-321607-3r736dnk	154	10	of	of	IN
cord-321607-3r736dnk	154	11	proteins	protein	NNS
cord-321607-3r736dnk	154	12	,	,	,
cord-321607-3r736dnk	154	13	damaged	damage	VBN
cord-321607-3r736dnk	154	14	organelles	organelle	NNS
cord-321607-3r736dnk	154	15	,	,	,
cord-321607-3r736dnk	154	16	and	and	CC
cord-321607-3r736dnk	154	17	pathogens	pathogen	NNS
cord-321607-3r736dnk	154	18	by	by	IN
cord-321607-3r736dnk	154	19	isolating	isolate	VBG
cord-321607-3r736dnk	154	20	them	-PRON-	PRP
cord-321607-3r736dnk	154	21	within	within	IN
cord-321607-3r736dnk	154	22	a	a	DT
cord-321607-3r736dnk	154	23	double	double	JJ
cord-321607-3r736dnk	154	24	-	-	HYPH
cord-321607-3r736dnk	154	25	membraned	membrane	VBN
cord-321607-3r736dnk	154	26	autophagosome	autophagosome	NN
cord-321607-3r736dnk	154	27	that	that	IN
cord-321607-3r736dnk	154	28	then	then	RB
cord-321607-3r736dnk	154	29	fuses	fuse	VBZ
cord-321607-3r736dnk	154	30	with	with	IN
cord-321607-3r736dnk	154	31	a	a	DT
cord-321607-3r736dnk	154	32	lysosome	lysosome	NN
cord-321607-3r736dnk	154	33	in	in	IN
cord-321607-3r736dnk	154	34	order	order	NN
cord-321607-3r736dnk	154	35	to	to	TO
cord-321607-3r736dnk	154	36	degrade	degrade	VB
cord-321607-3r736dnk	154	37	its	-PRON-	PRP$
cord-321607-3r736dnk	154	38	contents	content	NNS
cord-321607-3r736dnk	154	39	into	into	IN
cord-321607-3r736dnk	154	40	reusable	reusable	JJ
cord-321607-3r736dnk	154	41	components	component	NNS
cord-321607-3r736dnk	154	42	[	[	-LRB-
cord-321607-3r736dnk	154	43	102	102	CD
cord-321607-3r736dnk	154	44	]	]	-RRB-
cord-321607-3r736dnk	154	45	.	.	.
cord-321607-3r736dnk	155	1	RNase	RNase	NNP
cord-321607-3r736dnk	155	2	-	-	HYPH
cord-321607-3r736dnk	155	3	L	L	NNP
cord-321607-3r736dnk	155	4	induces	induce	VBZ
cord-321607-3r736dnk	155	5	autophagy	autophagy	NN
cord-321607-3r736dnk	155	6	in	in	IN
cord-321607-3r736dnk	155	7	response	response	NN
cord-321607-3r736dnk	155	8	to	to	IN
cord-321607-3r736dnk	155	9	viral	viral	JJ
cord-321607-3r736dnk	155	10	infection	infection	NN
cord-321607-3r736dnk	155	11	,	,	,
cord-321607-3r736dnk	155	12	or	or	CC
cord-321607-3r736dnk	155	13	more	more	RBR
cord-321607-3r736dnk	155	14	directly	directly	RB
cord-321607-3r736dnk	155	15	by	by	IN
cord-321607-3r736dnk	155	16	2	2	CD
cord-321607-3r736dnk	155	17	-	-	SYM
cord-321607-3r736dnk	155	18	5A.	5a.	CD
cord-321607-3r736dnk	156	1	The	the	DT
cord-321607-3r736dnk	156	2	signaling	signaling	NN
cord-321607-3r736dnk	156	3	involved	involve	VBN
cord-321607-3r736dnk	156	4	in	in	IN
cord-321607-3r736dnk	156	5	activating	activate	VBG
cord-321607-3r736dnk	156	6	this	this	DT
cord-321607-3r736dnk	156	7	process	process	NN
cord-321607-3r736dnk	156	8	involves	involve	VBZ
cord-321607-3r736dnk	156	9	both	both	DT
cord-321607-3r736dnk	156	10	c	c	NNP
cord-321607-3r736dnk	156	11	-	-	:
cord-321607-3r736dnk	156	12	Jun	Jun	NNP
cord-321607-3r736dnk	156	13	N	N	NNP
cord-321607-3r736dnk	156	14	-	-	HYPH
cord-321607-3r736dnk	156	15	terminal	terminal	NN
cord-321607-3r736dnk	156	16	kinase	kinase	NN
cord-321607-3r736dnk	156	17	and	and	CC
cord-321607-3r736dnk	156	18	PKR	PKR	NNP
cord-321607-3r736dnk	156	19	,	,	,
cord-321607-3r736dnk	156	20	resulting	result	VBG
cord-321607-3r736dnk	156	21	in	in	IN
cord-321607-3r736dnk	156	22	the	the	DT
cord-321607-3r736dnk	156	23	degradation	degradation	NN
cord-321607-3r736dnk	156	24	of	of	IN
cord-321607-3r736dnk	156	25	p62	p62	NN
cord-321607-3r736dnk	156	26	(	(	-LRB-
cord-321607-3r736dnk	156	27	SQSTM1	SQSTM1	NNP
cord-321607-3r736dnk	156	28	)	)	-RRB-
cord-321607-3r736dnk	156	29	,	,	,
cord-321607-3r736dnk	156	30	LCSBI	LCSBI	NNP
cord-321607-3r736dnk	156	31	/	/	SYM
cord-321607-3r736dnk	156	32	LCS3BII	LCS3BII	NNP
cord-321607-3r736dnk	156	33	conversion	conversion	NN
cord-321607-3r736dnk	156	34	,	,	,
cord-321607-3r736dnk	156	35	and	and	CC
cord-321607-3r736dnk	156	36	the	the	DT
cord-321607-3r736dnk	156	37	accumulation	accumulation	NN
cord-321607-3r736dnk	156	38	of	of	IN
cord-321607-3r736dnk	156	39	autophagosomes	autophagosomes	NNP
cord-321607-3r736dnk	156	40	,	,	,
cord-321607-3r736dnk	156	41	all	all	DT
cord-321607-3r736dnk	156	42	hallmarks	hallmark	NNS
cord-321607-3r736dnk	156	43	of	of	IN
cord-321607-3r736dnk	156	44	autophagy	autophagy	NN
cord-321607-3r736dnk	156	45	.	.	.
cord-321607-3r736dnk	157	1	RNase	RNase	NNP
cord-321607-3r736dnk	157	2	-	-	HYPH
cord-321607-3r736dnk	157	3	L	l	NN
cord-321607-3r736dnk	157	4	-	-	HYPH
cord-321607-3r736dnk	157	5	induced	induce	VBN
cord-321607-3r736dnk	157	6	autophagy	autophagy	NN
cord-321607-3r736dnk	157	7	was	be	VBD
cord-321607-3r736dnk	157	8	shown	show	VBN
cord-321607-3r736dnk	157	9	to	to	TO
cord-321607-3r736dnk	157	10	be	be	VB
cord-321607-3r736dnk	157	11	detrimental	detrimental	JJ
cord-321607-3r736dnk	157	12	to	to	IN
cord-321607-3r736dnk	157	13	virus	virus	NN
cord-321607-3r736dnk	157	14	replication	replication	NN
cord-321607-3r736dnk	157	15	in	in	IN
cord-321607-3r736dnk	157	16	the	the	DT
cord-321607-3r736dnk	157	17	early	early	JJ
cord-321607-3r736dnk	157	18	stages	stage	NNS
cord-321607-3r736dnk	157	19	of	of	IN
cord-321607-3r736dnk	157	20	infection	infection	NN
cord-321607-3r736dnk	157	21	and	and	CC
cord-321607-3r736dnk	157	22	then	then	RB
cord-321607-3r736dnk	157	23	advantageous	advantageous	JJ
cord-321607-3r736dnk	157	24	in	in	IN
cord-321607-3r736dnk	157	25	later	later	JJ
cord-321607-3r736dnk	157	26	stages	stage	NNS
cord-321607-3r736dnk	157	27	,	,	,
cord-321607-3r736dnk	157	28	or	or	CC
cord-321607-3r736dnk	157	29	under	under	IN
cord-321607-3r736dnk	157	30	high	high	JJ
cord-321607-3r736dnk	157	31	infectious	infectious	JJ
cord-321607-3r736dnk	157	32	doses	dose	NNS
cord-321607-3r736dnk	157	33	of	of	IN
cord-321607-3r736dnk	157	34	virus	virus	NN
cord-321607-3r736dnk	157	35	[	[	-LRB-
cord-321607-3r736dnk	157	36	29	29	CD
cord-321607-3r736dnk	157	37	,	,	,
cord-321607-3r736dnk	157	38	103	103	CD
cord-321607-3r736dnk	157	39	]	]	-RRB-
cord-321607-3r736dnk	157	40	.	.	.
cord-321607-3r736dnk	158	1	It	-PRON-	PRP
cord-321607-3r736dnk	158	2	has	have	VBZ
cord-321607-3r736dnk	158	3	previously	previously	RB
cord-321607-3r736dnk	158	4	been	be	VBN
cord-321607-3r736dnk	158	5	shown	show	VBN
cord-321607-3r736dnk	158	6	that	that	IN
cord-321607-3r736dnk	158	7	autophagy	autophagy	NN
cord-321607-3r736dnk	158	8	suppresses	suppress	VBZ
cord-321607-3r736dnk	158	9	apoptosis	apoptosis	NN
cord-321607-3r736dnk	158	10	at	at	IN
cord-321607-3r736dnk	158	11	early	early	JJ
cord-321607-3r736dnk	158	12	timepoints	timepoint	NNS
cord-321607-3r736dnk	158	13	in	in	IN
cord-321607-3r736dnk	158	14	order	order	NN
cord-321607-3r736dnk	158	15	to	to	TO
cord-321607-3r736dnk	158	16	give	give	VB
cord-321607-3r736dnk	158	17	the	the	DT
cord-321607-3r736dnk	158	18	cell	cell	NN
cord-321607-3r736dnk	158	19	time	time	NN
cord-321607-3r736dnk	158	20	to	to	TO
cord-321607-3r736dnk	158	21	recover	recover	VB
cord-321607-3r736dnk	158	22	.	.	.
cord-321607-3r736dnk	159	1	If	if	IN
cord-321607-3r736dnk	159	2	the	the	DT
cord-321607-3r736dnk	159	3	activating	activate	VBG
cord-321607-3r736dnk	159	4	stressor	stressor	NN
cord-321607-3r736dnk	159	5	continues	continue	VBZ
cord-321607-3r736dnk	159	6	or	or	CC
cord-321607-3r736dnk	159	7	autophagy	autophagy	NN
cord-321607-3r736dnk	159	8	is	be	VBZ
cord-321607-3r736dnk	159	9	excessive	excessive	JJ
cord-321607-3r736dnk	159	10	,	,	,
cord-321607-3r736dnk	159	11	the	the	DT
cord-321607-3r736dnk	159	12	cell	cell	NN
cord-321607-3r736dnk	159	13	can	can	MD
cord-321607-3r736dnk	159	14	then	then	RB
cord-321607-3r736dnk	159	15	switch	switch	VB
cord-321607-3r736dnk	159	16	in	in	IN
cord-321607-3r736dnk	159	17	favor	favor	NN
cord-321607-3r736dnk	159	18	of	of	IN
cord-321607-3r736dnk	159	19	a	a	DT
cord-321607-3r736dnk	159	20	cell	cell	NN
cord-321607-3r736dnk	159	21	death	death	NN
cord-321607-3r736dnk	159	22	response	response	NN
cord-321607-3r736dnk	159	23	[	[	-LRB-
cord-321607-3r736dnk	159	24	104	104	CD
cord-321607-3r736dnk	159	25	]	]	-RRB-
cord-321607-3r736dnk	159	26	.	.	.
cord-321607-3r736dnk	160	1	Recently	recently	RB
cord-321607-3r736dnk	160	2	,	,	,
cord-321607-3r736dnk	160	3	Siddiqui	Siddiqui	NNP
cord-321607-3r736dnk	160	4	et	et	NNP
cord-321607-3r736dnk	160	5	al	al	NNP
cord-321607-3r736dnk	160	6	.	.	.
cord-321607-3r736dnk	161	1	[	[	-LRB-
cord-321607-3r736dnk	161	2	30	30	CD
cord-321607-3r736dnk	161	3	]	]	-RRB-
cord-321607-3r736dnk	161	4	,	,	,
cord-321607-3r736dnk	161	5	have	have	VBP
cord-321607-3r736dnk	161	6	shown	show	VBN
cord-321607-3r736dnk	161	7	that	that	IN
cord-321607-3r736dnk	161	8	RNase	RNase	NNP
cord-321607-3r736dnk	161	9	-	-	HYPH
cord-321607-3r736dnk	161	10	L	l	NN
cord-321607-3r736dnk	161	11	cleavage	cleavage	NN
cord-321607-3r736dnk	161	12	products	product	NNS
cord-321607-3r736dnk	161	13	can	can	MD
cord-321607-3r736dnk	161	14	promote	promote	VB
cord-321607-3r736dnk	161	15	this	this	DT
cord-321607-3r736dnk	161	16	switch	switch	NN
cord-321607-3r736dnk	161	17	to	to	IN
cord-321607-3r736dnk	161	18	apoptosis	apoptosis	NN
cord-321607-3r736dnk	161	19	by	by	IN
cord-321607-3r736dnk	161	20	activating	activate	VBG
cord-321607-3r736dnk	161	21	caspase-3	caspase-3	NNP
cord-321607-3r736dnk	161	22	to	to	TO
cord-321607-3r736dnk	161	23	cleave	cleave	VB
cord-321607-3r736dnk	161	24	Beclin-1	Beclin-1	NNP
cord-321607-3r736dnk	161	25	,	,	,
cord-321607-3r736dnk	161	26	which	which	WDT
cord-321607-3r736dnk	161	27	then	then	RB
cord-321607-3r736dnk	161	28	translocates	translocate	VBZ
cord-321607-3r736dnk	161	29	to	to	IN
cord-321607-3r736dnk	161	30	the	the	DT
cord-321607-3r736dnk	161	31	mitochondria	mitochondrion	NNS
cord-321607-3r736dnk	161	32	to	to	TO
cord-321607-3r736dnk	161	33	induce	induce	VB
cord-321607-3r736dnk	161	34	cytochrome	cytochrome	NN
cord-321607-3r736dnk	161	35	c	c	NN
cord-321607-3r736dnk	161	36	release	release	NN
cord-321607-3r736dnk	161	37	.	.	.
cord-321607-3r736dnk	162	1	Like	like	IN
cord-321607-3r736dnk	162	2	the	the	DT
cord-321607-3r736dnk	162	3	induction	induction	NN
cord-321607-3r736dnk	162	4	of	of	IN
cord-321607-3r736dnk	162	5	autophagy	autophagy	NN
cord-321607-3r736dnk	162	6	,	,	,
cord-321607-3r736dnk	162	7	the	the	DT
cord-321607-3r736dnk	162	8	exact	exact	JJ
cord-321607-3r736dnk	162	9	mechanisms	mechanism	NNS
cord-321607-3r736dnk	162	10	for	for	IN
cord-321607-3r736dnk	162	11	many	many	JJ
cord-321607-3r736dnk	162	12	of	of	IN
cord-321607-3r736dnk	162	13	the	the	DT
cord-321607-3r736dnk	162	14	cellular	cellular	JJ
cord-321607-3r736dnk	162	15	functions	function	NNS
cord-321607-3r736dnk	162	16	of	of	IN
cord-321607-3r736dnk	162	17	RNase	RNase	NNP
cord-321607-3r736dnk	162	18	-	-	HYPH
cord-321607-3r736dnk	162	19	L	L	NNP
cord-321607-3r736dnk	162	20	are	be	VBP
cord-321607-3r736dnk	162	21	unknown	unknown	JJ
cord-321607-3r736dnk	162	22	.	.	.
cord-321607-3r736dnk	163	1	It	-PRON-	PRP
cord-321607-3r736dnk	163	2	is	be	VBZ
cord-321607-3r736dnk	163	3	broadly	broadly	RB
cord-321607-3r736dnk	163	4	believed	believe	VBN
cord-321607-3r736dnk	163	5	that	that	IN
cord-321607-3r736dnk	163	6	the	the	DT
cord-321607-3r736dnk	163	7	regulation	regulation	NN
cord-321607-3r736dnk	163	8	of	of	IN
cord-321607-3r736dnk	163	9	gene	gene	NN
cord-321607-3r736dnk	163	10	expression	expression	NN
cord-321607-3r736dnk	163	11	plays	play	VBZ
cord-321607-3r736dnk	163	12	a	a	DT
cord-321607-3r736dnk	163	13	major	major	JJ
cord-321607-3r736dnk	163	14	role	role	NN
cord-321607-3r736dnk	163	15	in	in	IN
cord-321607-3r736dnk	163	16	facilitating	facilitate	VBG
cord-321607-3r736dnk	163	17	these	these	DT
cord-321607-3r736dnk	163	18	activities	activity	NNS
cord-321607-3r736dnk	163	19	,	,	,
cord-321607-3r736dnk	163	20	such	such	JJ
cord-321607-3r736dnk	163	21	as	as	IN
cord-321607-3r736dnk	163	22	the	the	DT
cord-321607-3r736dnk	163	23	modulation	modulation	NN
cord-321607-3r736dnk	163	24	of	of	IN
cord-321607-3r736dnk	163	25	the	the	DT
cord-321607-3r736dnk	163	26	immune	immune	JJ
cord-321607-3r736dnk	163	27	response	response	NN
cord-321607-3r736dnk	163	28	.	.	.
cord-321607-3r736dnk	164	1	The	the	DT
cord-321607-3r736dnk	164	2	gene	gene	NN
cord-321607-3r736dnk	164	3	most	most	RBS
cord-321607-3r736dnk	164	4	notably	notably	RB
cord-321607-3r736dnk	164	5	regulated	regulate	VBN
cord-321607-3r736dnk	164	6	by	by	IN
cord-321607-3r736dnk	164	7	RNase	RNase	NNP
cord-321607-3r736dnk	164	8	-	-	HYPH
cord-321607-3r736dnk	164	9	L	L	NNP
cord-321607-3r736dnk	164	10	is	be	VBZ
cord-321607-3r736dnk	164	11	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	164	12	.	.	.
cord-321607-3r736dnk	165	1	In	in	IN
cord-321607-3r736dnk	165	2	2007	2007	CD
cord-321607-3r736dnk	165	3	,	,	,
cord-321607-3r736dnk	165	4	Malathi	Malathi	NNP
cord-321607-3r736dnk	165	5	et	et	NNP
cord-321607-3r736dnk	165	6	al	al	NNP
cord-321607-3r736dnk	165	7	.	.	.
cord-321607-3r736dnk	166	1	[	[	-LRB-
cord-321607-3r736dnk	166	2	27	27	CD
cord-321607-3r736dnk	166	3	]	]	-RRB-
cord-321607-3r736dnk	166	4	showed	show	VBD
cord-321607-3r736dnk	166	5	that	that	IN
cord-321607-3r736dnk	166	6	activated	activate	VBN
cord-321607-3r736dnk	166	7	RNase	RNase	NNP
cord-321607-3r736dnk	166	8	-	-	HYPH
cord-321607-3r736dnk	166	9	L	L	NNP
cord-321607-3r736dnk	166	10	cleaved	cleave	VBD
cord-321607-3r736dnk	166	11	cellular	cellular	JJ
cord-321607-3r736dnk	166	12	and	and	CC
cord-321607-3r736dnk	166	13	viral	viral	JJ
cord-321607-3r736dnk	166	14	RNAs	rna	NNS
cord-321607-3r736dnk	166	15	into	into	IN
cord-321607-3r736dnk	166	16	small	small	JJ
cord-321607-3r736dnk	166	17	RNAs	rna	NNS
cord-321607-3r736dnk	166	18	(	(	-LRB-
cord-321607-3r736dnk	166	19	<	<	NNP
cord-321607-3r736dnk	166	20	200	200	CD
cord-321607-3r736dnk	166	21	bp	bp	NNP
cord-321607-3r736dnk	166	22	)	)	-RRB-
cord-321607-3r736dnk	166	23	that	that	WDT
cord-321607-3r736dnk	166	24	often	often	RB
cord-321607-3r736dnk	166	25	form	form	VBP
cord-321607-3r736dnk	166	26	a	a	DT
cord-321607-3r736dnk	166	27	duplex	duplex	NN
cord-321607-3r736dnk	166	28	.	.	.
cord-321607-3r736dnk	167	1	These	these	DT
cord-321607-3r736dnk	167	2	small	small	JJ
cord-321607-3r736dnk	167	3	RNAs	rna	NNS
cord-321607-3r736dnk	167	4	are	be	VBP
cord-321607-3r736dnk	167	5	capable	capable	JJ
cord-321607-3r736dnk	167	6	of	of	IN
cord-321607-3r736dnk	167	7	stimulating	stimulate	VBG
cord-321607-3r736dnk	167	8	RIG	rig	NN
cord-321607-3r736dnk	167	9	-	-	:
cord-321607-3r736dnk	167	10	I	I	NNP
cord-321607-3r736dnk	167	11	and	and	CC
cord-321607-3r736dnk	167	12	MDA5	MDA5	NNP
cord-321607-3r736dnk	168	1	(	(	-LRB-
cord-321607-3r736dnk	168	2	melanoma	melanoma	NN
cord-321607-3r736dnk	168	3	differentiation	differentiation	NN
cord-321607-3r736dnk	168	4	associated	associate	VBN
cord-321607-3r736dnk	168	5	gene-5	gene-5	NNP
cord-321607-3r736dnk	168	6	)	)	-RRB-
cord-321607-3r736dnk	168	7	to	to	TO
cord-321607-3r736dnk	168	8	activate	activate	VB
cord-321607-3r736dnk	168	9	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	168	10	antiviral	antiviral	JJ
cord-321607-3r736dnk	168	11	signaling	signal	VBG
cord-321607-3r736dnk	168	12	protein	protein	NN
cord-321607-3r736dnk	168	13	(	(	-LRB-
cord-321607-3r736dnk	168	14	MAVS	MAVS	NNP
cord-321607-3r736dnk	168	15	)	)	-RRB-
cord-321607-3r736dnk	168	16	and	and	CC
cord-321607-3r736dnk	168	17	induce	induce	VB
cord-321607-3r736dnk	168	18	the	the	DT
cord-321607-3r736dnk	168	19	subsequent	subsequent	JJ
cord-321607-3r736dnk	168	20	translocation	translocation	NN
cord-321607-3r736dnk	168	21	of	of	IN
cord-321607-3r736dnk	168	22	interferon	interferon	NN
cord-321607-3r736dnk	168	23	regulatory	regulatory	JJ
cord-321607-3r736dnk	168	24	factor	factor	NN
cord-321607-3r736dnk	168	25	3	3	CD
cord-321607-3r736dnk	168	26	(	(	-LRB-
cord-321607-3r736dnk	168	27	IRF3	IRF3	NNP
cord-321607-3r736dnk	168	28	)	)	-RRB-
cord-321607-3r736dnk	168	29	to	to	IN
cord-321607-3r736dnk	168	30	the	the	DT
cord-321607-3r736dnk	168	31	nucleus	nucleus	NN
cord-321607-3r736dnk	168	32	to	to	TO
cord-321607-3r736dnk	168	33	drive	drive	VB
cord-321607-3r736dnk	168	34	transcription	transcription	NN
cord-321607-3r736dnk	168	35	of	of	IN
cord-321607-3r736dnk	168	36	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	168	37	.	.	.
cord-321607-3r736dnk	169	1	Once	once	RB
cord-321607-3r736dnk	169	2	secreted	secrete	VBN
cord-321607-3r736dnk	169	3	,	,	,
cord-321607-3r736dnk	169	4	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	169	5	can	can	MD
cord-321607-3r736dnk	169	6	not	not	RB
cord-321607-3r736dnk	169	7	only	only	RB
cord-321607-3r736dnk	169	8	create	create	VB
cord-321607-3r736dnk	169	9	an	an	DT
cord-321607-3r736dnk	169	10	antiviral	antiviral	JJ
cord-321607-3r736dnk	169	11	state	state	NN
cord-321607-3r736dnk	169	12	in	in	IN
cord-321607-3r736dnk	169	13	surrounding	surround	VBG
cord-321607-3r736dnk	169	14	cells	cell	NNS
cord-321607-3r736dnk	169	15	,	,	,
cord-321607-3r736dnk	169	16	but	but	CC
cord-321607-3r736dnk	169	17	it	-PRON-	PRP
cord-321607-3r736dnk	169	18	can	can	MD
cord-321607-3r736dnk	169	19	affect	affect	VB
cord-321607-3r736dnk	169	20	immunoglobulin	immunoglobulin	NN
cord-321607-3r736dnk	169	21	class	class	NN
cord-321607-3r736dnk	169	22	switching	switch	VBG
cord-321607-3r736dnk	169	23	in	in	IN
cord-321607-3r736dnk	169	24	B	b	NN
cord-321607-3r736dnk	169	25	cells	cell	NNS
cord-321607-3r736dnk	169	26	as	as	RB
cord-321607-3r736dnk	169	27	well	well	RB
cord-321607-3r736dnk	169	28	as	as	IN
cord-321607-3r736dnk	169	29	T	T	NNP
cord-321607-3r736dnk	169	30	and	and	CC
cord-321607-3r736dnk	169	31	NK	NK	NNP
cord-321607-3r736dnk	169	32	cell	cell	NN
cord-321607-3r736dnk	169	33	activation	activation	NN
cord-321607-3r736dnk	169	34	,	,	,
cord-321607-3r736dnk	169	35	affecting	affect	VBG
cord-321607-3r736dnk	169	36	the	the	DT
cord-321607-3r736dnk	169	37	adaptive	adaptive	JJ
cord-321607-3r736dnk	169	38	immune	immune	JJ
cord-321607-3r736dnk	169	39	response	response	NN
cord-321607-3r736dnk	169	40	to	to	IN
cord-321607-3r736dnk	169	41	pathogens	pathogen	NNS
cord-321607-3r736dnk	169	42	[	[	-LRB-
cord-321607-3r736dnk	169	43	105	105	CD
cord-321607-3r736dnk	169	44	]	]	-RRB-
cord-321607-3r736dnk	170	1	[	[	-LRB-
cord-321607-3r736dnk	170	2	106	106	CD
cord-321607-3r736dnk	170	3	]	]	-RRB-
cord-321607-3r736dnk	170	4	[	[	-LRB-
cord-321607-3r736dnk	170	5	107	107	CD
cord-321607-3r736dnk	170	6	]	]	-RRB-
cord-321607-3r736dnk	170	7	.	.	.
cord-321607-3r736dnk	171	1	Skin	skin	NN
cord-321607-3r736dnk	171	2	allograft	allograft	NN
cord-321607-3r736dnk	171	3	rejection	rejection	NN
cord-321607-3r736dnk	171	4	and	and	CC
cord-321607-3r736dnk	171	5	contact	contact	NN
cord-321607-3r736dnk	171	6	hypersensitivity	hypersensitivity	NN
cord-321607-3r736dnk	171	7	experiments	experiment	NNS
cord-321607-3r736dnk	171	8	conducted	conduct	VBN
cord-321607-3r736dnk	171	9	in	in	IN
cord-321607-3r736dnk	171	10	RNase	RNase	NNP
cord-321607-3r736dnk	171	11	-	-	HYPH
cord-321607-3r736dnk	171	12	L	L	NNP
cord-321607-3r736dnk	171	13	KO	KO	NNP
cord-321607-3r736dnk	171	14	and	and	CC
cord-321607-3r736dnk	171	15	WT	WT	NNP
cord-321607-3r736dnk	171	16	mice	mouse	NNS
cord-321607-3r736dnk	171	17	revealed	reveal	VBD
cord-321607-3r736dnk	171	18	a	a	DT
cord-321607-3r736dnk	171	19	five	five	CD
cord-321607-3r736dnk	171	20	day	day	NN
cord-321607-3r736dnk	171	21	delay	delay	NN
cord-321607-3r736dnk	171	22	in	in	IN
cord-321607-3r736dnk	171	23	allograft	allograft	NN
cord-321607-3r736dnk	171	24	rejection	rejection	NN
cord-321607-3r736dnk	171	25	in	in	IN
cord-321607-3r736dnk	171	26	the	the	DT
cord-321607-3r736dnk	171	27	KO	KO	NNP
cord-321607-3r736dnk	171	28	mice	mouse	NNS
cord-321607-3r736dnk	171	29	and	and	CC
cord-321607-3r736dnk	171	30	a	a	DT
cord-321607-3r736dnk	171	31	reduction	reduction	NN
cord-321607-3r736dnk	171	32	of	of	IN
cord-321607-3r736dnk	171	33	inflammatory	inflammatory	JJ
cord-321607-3r736dnk	171	34	infiltrates	infiltrate	NNS
cord-321607-3r736dnk	171	35	[	[	-LRB-
cord-321607-3r736dnk	171	36	31	31	CD
cord-321607-3r736dnk	171	37	]	]	-RRB-
cord-321607-3r736dnk	171	38	.	.	.
cord-321607-3r736dnk	172	1	This	this	DT
cord-321607-3r736dnk	172	2	may	may	MD
cord-321607-3r736dnk	172	3	indicate	indicate	VB
cord-321607-3r736dnk	172	4	a	a	DT
cord-321607-3r736dnk	172	5	defect	defect	NN
cord-321607-3r736dnk	172	6	in	in	IN
cord-321607-3r736dnk	172	7	T	t	NN
cord-321607-3r736dnk	172	8	-	-	HYPH
cord-321607-3r736dnk	172	9	cell	cell	NN
cord-321607-3r736dnk	172	10	priming	priming	NN
cord-321607-3r736dnk	172	11	or	or	CC
cord-321607-3r736dnk	172	12	immune	immune	JJ
cord-321607-3r736dnk	172	13	cell	cell	NN
cord-321607-3r736dnk	172	14	trafficking	trafficking	NN
cord-321607-3r736dnk	172	15	;	;	:
cord-321607-3r736dnk	172	16	however	however	RB
cord-321607-3r736dnk	172	17	,	,	,
cord-321607-3r736dnk	172	18	further	further	JJ
cord-321607-3r736dnk	172	19	studies	study	NNS
cord-321607-3r736dnk	172	20	are	be	VBP
cord-321607-3r736dnk	172	21	required	require	VBN
cord-321607-3r736dnk	172	22	to	to	TO
cord-321607-3r736dnk	172	23	determine	determine	VB
cord-321607-3r736dnk	172	24	the	the	DT
cord-321607-3r736dnk	172	25	exact	exact	JJ
cord-321607-3r736dnk	172	26	mechanism	mechanism	NN
cord-321607-3r736dnk	172	27	for	for	IN
cord-321607-3r736dnk	172	28	RNase	RNase	NNP
cord-321607-3r736dnk	172	29	-	-	HYPH
cord-321607-3r736dnk	172	30	L	l	NN
cord-321607-3r736dnk	172	31	activity	activity	NN
cord-321607-3r736dnk	172	32	.	.	.
cord-321607-3r736dnk	173	1	The	the	DT
cord-321607-3r736dnk	173	2	possible	possible	JJ
cord-321607-3r736dnk	173	3	involvement	involvement	NN
cord-321607-3r736dnk	173	4	of	of	IN
cord-321607-3r736dnk	173	5	RNase	RNase	NNP
cord-321607-3r736dnk	173	6	-	-	HYPH
cord-321607-3r736dnk	173	7	L	L	NNP
cord-321607-3r736dnk	173	8	in	in	IN
cord-321607-3r736dnk	173	9	T	T	NNP
cord-321607-3r736dnk	173	10	cell	cell	NN
cord-321607-3r736dnk	173	11	function	function	NN
cord-321607-3r736dnk	173	12	is	be	VBZ
cord-321607-3r736dnk	173	13	not	not	RB
cord-321607-3r736dnk	173	14	surprising	surprising	JJ
cord-321607-3r736dnk	173	15	,	,	,
cord-321607-3r736dnk	173	16	as	as	IN
cord-321607-3r736dnk	173	17	RNase	RNase	NNP
cord-321607-3r736dnk	173	18	-	-	HYPH
cord-321607-3r736dnk	173	19	L	L	NNP
cord-321607-3r736dnk	173	20	KO	KO	NNP
cord-321607-3r736dnk	173	21	mice	mouse	NNS
cord-321607-3r736dnk	173	22	have	have	VBP
cord-321607-3r736dnk	173	23	enlarged	enlarge	VBN
cord-321607-3r736dnk	173	24	thymuses	thymus	NNS
cord-321607-3r736dnk	173	25	,	,	,
cord-321607-3r736dnk	173	26	likely	likely	RB
cord-321607-3r736dnk	173	27	due	due	IN
cord-321607-3r736dnk	173	28	to	to	IN
cord-321607-3r736dnk	173	29	defects	defect	NNS
cord-321607-3r736dnk	173	30	in	in	IN
cord-321607-3r736dnk	173	31	apoptosis	apoptosis	NN
cord-321607-3r736dnk	173	32	.	.	.
cord-321607-3r736dnk	174	1	Other	other	JJ
cord-321607-3r736dnk	174	2	investigations	investigation	NNS
cord-321607-3r736dnk	174	3	of	of	IN
cord-321607-3r736dnk	174	4	immune	immune	JJ
cord-321607-3r736dnk	174	5	cell	cell	NN
cord-321607-3r736dnk	174	6	functions	function	NNS
cord-321607-3r736dnk	174	7	have	have	VBP
cord-321607-3r736dnk	174	8	shown	show	VBN
cord-321607-3r736dnk	174	9	that	that	IN
cord-321607-3r736dnk	174	10	,	,	,
cord-321607-3r736dnk	174	11	in	in	IN
cord-321607-3r736dnk	174	12	addition	addition	NN
cord-321607-3r736dnk	174	13	to	to	IN
cord-321607-3r736dnk	174	14	our	-PRON-	PRP$
cord-321607-3r736dnk	174	15	work	work	NN
cord-321607-3r736dnk	174	16	with	with	IN
cord-321607-3r736dnk	174	17	E.	E.	NNP
cord-321607-3r736dnk	174	18	coli	coli	NNS
cord-321607-3r736dnk	174	19	and	and	CC
cord-321607-3r736dnk	174	20	BA	BA	NNP
cord-321607-3r736dnk	174	21	infections	infection	NNS
cord-321607-3r736dnk	174	22	above	above	RB
cord-321607-3r736dnk	174	23	,	,	,
cord-321607-3r736dnk	174	24	macrophages	macrophage	NNS
cord-321607-3r736dnk	174	25	deficient	deficient	JJ
cord-321607-3r736dnk	174	26	in	in	IN
cord-321607-3r736dnk	174	27	RNase	RNase	NNP
cord-321607-3r736dnk	174	28	-	-	HYPH
cord-321607-3r736dnk	174	29	L	l	NN
cord-321607-3r736dnk	174	30	exhibit	exhibit	NN
cord-321607-3r736dnk	175	1	decreased	decrease	VBN
cord-321607-3r736dnk	175	2	migration	migration	NN
cord-321607-3r736dnk	175	3	,	,	,
cord-321607-3r736dnk	175	4	endocytic	endocytic	JJ
cord-321607-3r736dnk	175	5	activity	activity	NN
cord-321607-3r736dnk	175	6	,	,	,
cord-321607-3r736dnk	175	7	and	and	CC
cord-321607-3r736dnk	175	8	proinflammatory	proinflammatory	JJ
cord-321607-3r736dnk	175	9	gene	gene	NN
cord-321607-3r736dnk	175	10	regulation	regulation	NN
cord-321607-3r736dnk	175	11	[	[	-LRB-
cord-321607-3r736dnk	175	12	26	26	CD
cord-321607-3r736dnk	175	13	,	,	,
cord-321607-3r736dnk	175	14	32	32	CD
cord-321607-3r736dnk	175	15	]	]	-RRB-
cord-321607-3r736dnk	175	16	.	.	.
cord-321607-3r736dnk	176	1	These	these	DT
cord-321607-3r736dnk	176	2	data	datum	NNS
cord-321607-3r736dnk	176	3	clearly	clearly	RB
cord-321607-3r736dnk	176	4	indicate	indicate	VBP
cord-321607-3r736dnk	176	5	that	that	IN
cord-321607-3r736dnk	176	6	RNase	RNase	NNP
cord-321607-3r736dnk	176	7	-	-	HYPH
cord-321607-3r736dnk	176	8	L	L	NNP
cord-321607-3r736dnk	176	9	has	have	VBZ
cord-321607-3r736dnk	176	10	an	an	DT
cord-321607-3r736dnk	176	11	important	important	JJ
cord-321607-3r736dnk	176	12	role	role	NN
cord-321607-3r736dnk	176	13	in	in	IN
cord-321607-3r736dnk	176	14	immune	immune	JJ
cord-321607-3r736dnk	176	15	cell	cell	NN
cord-321607-3r736dnk	176	16	function	function	NN
cord-321607-3r736dnk	176	17	,	,	,
cord-321607-3r736dnk	176	18	including	include	VBG
cord-321607-3r736dnk	176	19	the	the	DT
cord-321607-3r736dnk	176	20	adaptive	adaptive	JJ
cord-321607-3r736dnk	176	21	response	response	NN
cord-321607-3r736dnk	176	22	.	.	.
cord-321607-3r736dnk	177	1	In	in	IN
cord-321607-3r736dnk	177	2	addition	addition	NN
cord-321607-3r736dnk	177	3	to	to	TO
cord-321607-3r736dnk	177	4	type	type	VB
cord-321607-3r736dnk	177	5	I	-PRON-	PRP
cord-321607-3r736dnk	177	6	IFN	IFN	NNP
cord-321607-3r736dnk	177	7	and	and	CC
cord-321607-3r736dnk	177	8	TLR	TLR	NNP
cord-321607-3r736dnk	177	9	signaling	signaling	NN
cord-321607-3r736dnk	177	10	,	,	,
cord-321607-3r736dnk	177	11	which	which	WDT
cord-321607-3r736dnk	177	12	were	be	VBD
cord-321607-3r736dnk	177	13	shown	show	VBN
cord-321607-3r736dnk	177	14	to	to	TO
cord-321607-3r736dnk	177	15	be	be	VB
cord-321607-3r736dnk	177	16	regulated	regulate	VBN
cord-321607-3r736dnk	177	17	by	by	IN
cord-321607-3r736dnk	177	18	RNase	RNase	NNP
cord-321607-3r736dnk	177	19	-	-	HYPH
cord-321607-3r736dnk	177	20	L	l	NN
cord-321607-3r736dnk	177	21	during	during	IN
cord-321607-3r736dnk	177	22	bacterial	bacterial	JJ
cord-321607-3r736dnk	177	23	infection	infection	NN
cord-321607-3r736dnk	177	24	,	,	,
cord-321607-3r736dnk	177	25	another	another	DT
cord-321607-3r736dnk	177	26	family	family	NN
cord-321607-3r736dnk	177	27	of	of	IN
cord-321607-3r736dnk	177	28	innate	innate	JJ
cord-321607-3r736dnk	177	29	immune	immune	JJ
cord-321607-3r736dnk	177	30	regulators	regulator	NNS
cord-321607-3r736dnk	177	31	also	also	RB
cord-321607-3r736dnk	177	32	interacts	interact	VBZ
cord-321607-3r736dnk	177	33	with	with	IN
cord-321607-3r736dnk	177	34	the	the	DT
cord-321607-3r736dnk	177	35	OAS	OAS	NNP
cord-321607-3r736dnk	177	36	/	/	SYM
cord-321607-3r736dnk	177	37	RNase	RNase	NNP
cord-321607-3r736dnk	177	38	-	-	HYPH
cord-321607-3r736dnk	177	39	L	L	NNP
cord-321607-3r736dnk	177	40	pathway	pathway	NN
cord-321607-3r736dnk	177	41	.	.	.
cord-321607-3r736dnk	178	1	Nucleotide	nucleotide	NN
cord-321607-3r736dnk	178	2	-	-	HYPH
cord-321607-3r736dnk	178	3	binding	bind	VBG
cord-321607-3r736dnk	178	4	and	and	CC
cord-321607-3r736dnk	178	5	oligomerization	oligomerization	NN
cord-321607-3r736dnk	178	6	domain	domain	NN
cord-321607-3r736dnk	178	7	(	(	-LRB-
cord-321607-3r736dnk	178	8	NOD)-like	nod)-like	CD
cord-321607-3r736dnk	178	9	receptors	receptor	NNS
cord-321607-3r736dnk	178	10	(	(	-LRB-
cord-321607-3r736dnk	178	11	NLR	NLR	NNP
cord-321607-3r736dnk	178	12	)	)	-RRB-
cord-321607-3r736dnk	178	13	detect	detect	VBP
cord-321607-3r736dnk	178	14	microbial	microbial	JJ
cord-321607-3r736dnk	178	15	products	product	NNS
cord-321607-3r736dnk	178	16	and	and	CC
cord-321607-3r736dnk	178	17	are	be	VBP
cord-321607-3r736dnk	178	18	divided	divide	VBN
cord-321607-3r736dnk	178	19	into	into	IN
cord-321607-3r736dnk	178	20	two	two	CD
cord-321607-3r736dnk	178	21	subsets	subset	NNS
cord-321607-3r736dnk	178	22	,	,	,
cord-321607-3r736dnk	178	23	those	those	DT
cord-321607-3r736dnk	178	24	that	that	WDT
cord-321607-3r736dnk	178	25	drive	drive	VBP
cord-321607-3r736dnk	178	26	mitogen	mitogen	NN
cord-321607-3r736dnk	178	27	-	-	HYPH
cord-321607-3r736dnk	178	28	activated	activate	VBN
cord-321607-3r736dnk	178	29	protein	protein	NN
cord-321607-3r736dnk	178	30	kinase	kinase	NN
cord-321607-3r736dnk	178	31	(	(	-LRB-
cord-321607-3r736dnk	178	32	MAPK	MAPK	NNP
cord-321607-3r736dnk	178	33	)	)	-RRB-
cord-321607-3r736dnk	178	34	and	and	CC
cord-321607-3r736dnk	178	35	nuclear	nuclear	JJ
cord-321607-3r736dnk	178	36	factor	factor	NN
cord-321607-3r736dnk	178	37	-	-	:
cord-321607-3r736dnk	178	38	κB	κB	NNP
cord-321607-3r736dnk	178	39	(	(	-LRB-
cord-321607-3r736dnk	178	40	NF	nf	NN
cord-321607-3r736dnk	178	41	-	-	HYPH
cord-321607-3r736dnk	178	42	κB	κB	NNP
cord-321607-3r736dnk	178	43	)	)	-RRB-
cord-321607-3r736dnk	178	44	signaling	signal	VBG
cord-321607-3r736dnk	178	45	(	(	-LRB-
cord-321607-3r736dnk	178	46	such	such	JJ
cord-321607-3r736dnk	178	47	as	as	IN
cord-321607-3r736dnk	178	48	NOD1	NOD1	NNP
cord-321607-3r736dnk	178	49	and	and	CC
cord-321607-3r736dnk	178	50	NOD2	NOD2	NNPS
cord-321607-3r736dnk	178	51	)	)	-RRB-
cord-321607-3r736dnk	178	52	,	,	,
cord-321607-3r736dnk	178	53	and	and	CC
cord-321607-3r736dnk	178	54	those	those	DT
cord-321607-3r736dnk	178	55	that	that	WDT
cord-321607-3r736dnk	178	56	activate	activate	VBP
cord-321607-3r736dnk	178	57	the	the	DT
cord-321607-3r736dnk	178	58	inflammasome	inflammasome	NN
cord-321607-3r736dnk	178	59	,	,	,
cord-321607-3r736dnk	178	60	leading	lead	VBG
cord-321607-3r736dnk	178	61	to	to	IN
cord-321607-3r736dnk	178	62	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	178	63	,	,	,
cord-321607-3r736dnk	178	64	IL-18	IL-18	NNP
cord-321607-3r736dnk	178	65	,	,	,
cord-321607-3r736dnk	178	66	and	and	CC
cord-321607-3r736dnk	178	67	IL-1β	il-1β	JJ
cord-321607-3r736dnk	178	68	processing	processing	NN
cord-321607-3r736dnk	178	69	and	and	CC
cord-321607-3r736dnk	178	70	secretion	secretion	NN
cord-321607-3r736dnk	178	71	(	(	-LRB-
cord-321607-3r736dnk	178	72	including	include	VBG
cord-321607-3r736dnk	178	73	NLRPs	NLRPs	NNP
cord-321607-3r736dnk	178	74	1	1	CD
cord-321607-3r736dnk	178	75	,	,	,
cord-321607-3r736dnk	178	76	3	3	CD
cord-321607-3r736dnk	178	77	,	,	,
cord-321607-3r736dnk	178	78	and	and	CC
cord-321607-3r736dnk	178	79	4	4	CD
cord-321607-3r736dnk	178	80	and	and	CC
cord-321607-3r736dnk	178	81	AIM2	AIM2	NNP
cord-321607-3r736dnk	178	82	)	)	-RRB-
cord-321607-3r736dnk	178	83	[	[	-LRB-
cord-321607-3r736dnk	178	84	108	108	CD
cord-321607-3r736dnk	178	85	]	]	-RRB-
cord-321607-3r736dnk	178	86	.	.	.
cord-321607-3r736dnk	179	1	Recently	recently	RB
cord-321607-3r736dnk	179	2	,	,	,
cord-321607-3r736dnk	179	3	RNase	RNase	NNP
cord-321607-3r736dnk	179	4	-	-	HYPH
cord-321607-3r736dnk	179	5	L	L	NNP
cord-321607-3r736dnk	179	6	has	have	VBZ
cord-321607-3r736dnk	179	7	been	be	VBN
cord-321607-3r736dnk	179	8	shown	show	VBN
cord-321607-3r736dnk	179	9	to	to	TO
cord-321607-3r736dnk	179	10	play	play	VB
cord-321607-3r736dnk	179	11	a	a	DT
cord-321607-3r736dnk	179	12	role	role	NN
cord-321607-3r736dnk	179	13	in	in	IN
cord-321607-3r736dnk	179	14	the	the	DT
cord-321607-3r736dnk	179	15	activation	activation	NN
cord-321607-3r736dnk	179	16	of	of	IN
cord-321607-3r736dnk	179	17	the	the	DT
cord-321607-3r736dnk	179	18	NLRP3	NLRP3	NNP
cord-321607-3r736dnk	179	19	inflammasome	inflammasome	NNP
cord-321607-3r736dnk	179	20	.	.	.
cord-321607-3r736dnk	180	1	In	in	IN
cord-321607-3r736dnk	180	2	this	this	DT
cord-321607-3r736dnk	180	3	process	process	NN
cord-321607-3r736dnk	180	4	,	,	,
cord-321607-3r736dnk	180	5	RNase	RNase	NNP
cord-321607-3r736dnk	180	6	-	-	HYPH
cord-321607-3r736dnk	180	7	L	L	NNP
cord-321607-3r736dnk	180	8	is	be	VBZ
cord-321607-3r736dnk	180	9	activated	activate	VBN
cord-321607-3r736dnk	180	10	following	follow	VBG
cord-321607-3r736dnk	180	11	virus	virus	NN
cord-321607-3r736dnk	180	12	infection	infection	NN
cord-321607-3r736dnk	180	13	to	to	TO
cord-321607-3r736dnk	180	14	generate	generate	VB
cord-321607-3r736dnk	180	15	small	small	JJ
cord-321607-3r736dnk	180	16	RNA	RNA	NNP
cord-321607-3r736dnk	180	17	cleavage	cleavage	NN
cord-321607-3r736dnk	180	18	products	product	NNS
cord-321607-3r736dnk	180	19	that	that	WDT
cord-321607-3r736dnk	180	20	bind	bind	VBP
cord-321607-3r736dnk	180	21	to	to	IN
cord-321607-3r736dnk	180	22	the	the	DT
cord-321607-3r736dnk	180	23	DExD	DExD	NNS
cord-321607-3r736dnk	180	24	/	/	SYM
cord-321607-3r736dnk	180	25	H	h	NN
cord-321607-3r736dnk	180	26	helicase	helicase	NN
cord-321607-3r736dnk	180	27	DHX33	DHX33	NNP
cord-321607-3r736dnk	180	28	.	.	.
cord-321607-3r736dnk	181	1	This	this	DT
cord-321607-3r736dnk	181	2	leads	lead	VBZ
cord-321607-3r736dnk	181	3	to	to	IN
cord-321607-3r736dnk	181	4	the	the	DT
cord-321607-3r736dnk	181	5	formation	formation	NN
cord-321607-3r736dnk	181	6	of	of	IN
cord-321607-3r736dnk	181	7	a	a	DT
cord-321607-3r736dnk	181	8	DHX33	DHX33	NNP
cord-321607-3r736dnk	181	9	,	,	,
cord-321607-3r736dnk	181	10	NLRP3	nlrp3	NN
cord-321607-3r736dnk	181	11	,	,	,
cord-321607-3r736dnk	181	12	and	and	CC
cord-321607-3r736dnk	181	13	MAVS	mavs	RB
cord-321607-3r736dnk	181	14	complex	complex	JJ
cord-321607-3r736dnk	181	15	and	and	CC
cord-321607-3r736dnk	181	16	increased	increase	VBD
cord-321607-3r736dnk	182	1	IL-1β	il-1β	NN
cord-321607-3r736dnk	182	2	production	production	NN
cord-321607-3r736dnk	182	3	[	[	-LRB-
cord-321607-3r736dnk	182	4	83	83	CD
cord-321607-3r736dnk	182	5	]	]	-RRB-
cord-321607-3r736dnk	182	6	.	.	.
cord-321607-3r736dnk	183	1	Association	Association	NNP
cord-321607-3r736dnk	183	2	with	with	IN
cord-321607-3r736dnk	183	3	the	the	DT
cord-321607-3r736dnk	183	4	other	other	JJ
cord-321607-3r736dnk	183	5	subset	subset	NN
cord-321607-3r736dnk	183	6	of	of	IN
cord-321607-3r736dnk	183	7	NLRs	nlr	NNS
cord-321607-3r736dnk	183	8	occurs	occur	VBZ
cord-321607-3r736dnk	183	9	when	when	WRB
cord-321607-3r736dnk	183	10	OAS	OAS	NNP
cord-321607-3r736dnk	183	11	binds	bind	VBZ
cord-321607-3r736dnk	183	12	to	to	IN
cord-321607-3r736dnk	183	13	NOD2	NOD2	NNP
cord-321607-3r736dnk	183	14	.	.	.
cord-321607-3r736dnk	184	1	NOD2	NOD2	NNP
cord-321607-3r736dnk	184	2	is	be	VBZ
cord-321607-3r736dnk	184	3	activated	activate	VBN
cord-321607-3r736dnk	184	4	by	by	IN
cord-321607-3r736dnk	184	5	the	the	DT
cord-321607-3r736dnk	184	6	peptidoglycan	peptidoglycan	NN
cord-321607-3r736dnk	184	7	breakdown	breakdown	NN
cord-321607-3r736dnk	184	8	product	product	NN
cord-321607-3r736dnk	184	9	muramyl	muramyl	NNP
cord-321607-3r736dnk	184	10	dipeptide	dipeptide	NNP
cord-321607-3r736dnk	184	11	as	as	RB
cord-321607-3r736dnk	184	12	well	well	RB
cord-321607-3r736dnk	184	13	as	as	IN
cord-321607-3r736dnk	184	14	viral	viral	JJ
cord-321607-3r736dnk	184	15	ssRNA	ssrna	NN
cord-321607-3r736dnk	184	16	.	.	.
cord-321607-3r736dnk	185	1	Overexpression	Overexpression	NNP
cord-321607-3r736dnk	185	2	of	of	IN
cord-321607-3r736dnk	185	3	NOD2	NOD2	NNP
cord-321607-3r736dnk	185	4	when	when	WRB
cord-321607-3r736dnk	185	5	OAS	OAS	NNP
cord-321607-3r736dnk	185	6	is	be	VBZ
cord-321607-3r736dnk	185	7	active	active	JJ
cord-321607-3r736dnk	185	8	leads	lead	NNS
cord-321607-3r736dnk	185	9	to	to	IN
cord-321607-3r736dnk	185	10	increased	increase	VBN
cord-321607-3r736dnk	185	11	RNase	RNase	NNP
cord-321607-3r736dnk	185	12	-	-	HYPH
cord-321607-3r736dnk	185	13	L	l	NN
cord-321607-3r736dnk	185	14	activity	activity	NN
cord-321607-3r736dnk	185	15	,	,	,
cord-321607-3r736dnk	185	16	suggesting	suggest	VBG
cord-321607-3r736dnk	185	17	a	a	DT
cord-321607-3r736dnk	185	18	connection	connection	NN
cord-321607-3r736dnk	185	19	between	between	IN
cord-321607-3r736dnk	185	20	the	the	DT
cord-321607-3r736dnk	185	21	pathways	pathway	NNS
cord-321607-3r736dnk	185	22	[	[	-LRB-
cord-321607-3r736dnk	185	23	109	109	CD
cord-321607-3r736dnk	185	24	]	]	-RRB-
cord-321607-3r736dnk	185	25	.	.	.
cord-321607-3r736dnk	186	1	Any	any	DT
cord-321607-3r736dnk	186	2	effects	effect	NNS
cord-321607-3r736dnk	186	3	of	of	IN
cord-321607-3r736dnk	186	4	OAS	OAS	NNP
cord-321607-3r736dnk	186	5	interaction	interaction	NN
cord-321607-3r736dnk	186	6	on	on	IN
cord-321607-3r736dnk	186	7	NOD2	NOD2	NNP
cord-321607-3r736dnk	186	8	activation	activation	NN
cord-321607-3r736dnk	186	9	of	of	IN
cord-321607-3r736dnk	186	10	MAPK	MAPK	NNP
cord-321607-3r736dnk	186	11	or	or	CC
cord-321607-3r736dnk	186	12	NF	nf	NN
cord-321607-3r736dnk	186	13	-	-	HYPH
cord-321607-3r736dnk	186	14	κB	κB	NNP
cord-321607-3r736dnk	186	15	signaling	signaling	NN
cord-321607-3r736dnk	186	16	are	be	VBP
cord-321607-3r736dnk	186	17	unknown	unknown	JJ
cord-321607-3r736dnk	186	18	.	.	.
cord-321607-3r736dnk	187	1	The	the	DT
cord-321607-3r736dnk	187	2	long	long	RB
cord-321607-3r736dnk	187	3	-	-	HYPH
cord-321607-3r736dnk	187	4	standing	stand	VBG
cord-321607-3r736dnk	187	5	model	model	NN
cord-321607-3r736dnk	187	6	of	of	IN
cord-321607-3r736dnk	187	7	RNase	RNase	NNP
cord-321607-3r736dnk	187	8	-	-	HYPH
cord-321607-3r736dnk	187	9	L	l	NN
cord-321607-3r736dnk	187	10	activity	activity	NN
cord-321607-3r736dnk	187	11	involves	involve	VBZ
cord-321607-3r736dnk	187	12	low	low	JJ
cord-321607-3r736dnk	187	13	levels	level	NNS
cord-321607-3r736dnk	187	14	of	of	IN
cord-321607-3r736dnk	187	15	expression	expression	NN
cord-321607-3r736dnk	187	16	in	in	IN
cord-321607-3r736dnk	187	17	the	the	DT
cord-321607-3r736dnk	187	18	cytosol	cytosol	NN
cord-321607-3r736dnk	187	19	in	in	IN
cord-321607-3r736dnk	187	20	an	an	DT
cord-321607-3r736dnk	187	21	inactive	inactive	JJ
cord-321607-3r736dnk	187	22	conformation	conformation	NN
cord-321607-3r736dnk	187	23	,	,	,
cord-321607-3r736dnk	187	24	activation	activation	NN
cord-321607-3r736dnk	187	25	by	by	IN
cord-321607-3r736dnk	187	26	2	2	CD
cord-321607-3r736dnk	187	27	-	-	HYPH
cord-321607-3r736dnk	187	28	5A	5a	CD
cord-321607-3r736dnk	187	29	,	,	,
cord-321607-3r736dnk	187	30	and	and	CC
cord-321607-3r736dnk	187	31	cleavage	cleavage	NN
cord-321607-3r736dnk	187	32	of	of	IN
cord-321607-3r736dnk	187	33	ssRNA	ssrna	NN
cord-321607-3r736dnk	188	1	in	in	IN
cord-321607-3r736dnk	188	2	order	order	NN
cord-321607-3r736dnk	188	3	to	to	TO
cord-321607-3r736dnk	188	4	exert	exert	VB
cord-321607-3r736dnk	188	5	its	-PRON-	PRP$
cord-321607-3r736dnk	188	6	biological	biological	JJ
cord-321607-3r736dnk	188	7	functions	function	NNS
cord-321607-3r736dnk	188	8	.	.	.
cord-321607-3r736dnk	189	1	Though	though	IN
cord-321607-3r736dnk	189	2	all	all	DT
cord-321607-3r736dnk	189	3	of	of	IN
cord-321607-3r736dnk	189	4	this	this	DT
cord-321607-3r736dnk	189	5	is	be	VBZ
cord-321607-3r736dnk	189	6	well	well	RB
cord-321607-3r736dnk	189	7	-	-	HYPH
cord-321607-3r736dnk	189	8	documented	document	VBN
cord-321607-3r736dnk	189	9	,	,	,
cord-321607-3r736dnk	189	10	it	-PRON-	PRP
cord-321607-3r736dnk	189	11	does	do	VBZ
cord-321607-3r736dnk	189	12	not	not	RB
cord-321607-3r736dnk	189	13	address	address	VB
cord-321607-3r736dnk	189	14	whether	whether	IN
cord-321607-3r736dnk	189	15	constitutively	constitutively	RB
cord-321607-3r736dnk	189	16	expressed	express	VBN
cord-321607-3r736dnk	189	17	RNase	RNase	NNP
cord-321607-3r736dnk	189	18	-	-	HYPH
cord-321607-3r736dnk	189	19	L	L	NNP
cord-321607-3r736dnk	189	20	serves	serve	VBZ
cord-321607-3r736dnk	189	21	a	a	DT
cord-321607-3r736dnk	189	22	physiologic	physiologic	JJ
cord-321607-3r736dnk	189	23	role	role	NN
cord-321607-3r736dnk	189	24	in	in	IN
cord-321607-3r736dnk	189	25	the	the	DT
cord-321607-3r736dnk	189	26	absence	absence	NN
cord-321607-3r736dnk	189	27	of	of	IN
cord-321607-3r736dnk	189	28	2	2	CD
cord-321607-3r736dnk	189	29	-	-	SYM
cord-321607-3r736dnk	189	30	5A.	5a.	CD
cord-321607-3r736dnk	190	1	In	in	IN
cord-321607-3r736dnk	190	2	addition	addition	NN
cord-321607-3r736dnk	190	3	,	,	,
cord-321607-3r736dnk	190	4	while	while	IN
cord-321607-3r736dnk	190	5	RNase	RNase	NNP
cord-321607-3r736dnk	190	6	-	-	HYPH
cord-321607-3r736dnk	190	7	L	L	NNP
cord-321607-3r736dnk	190	8	is	be	VBZ
cord-321607-3r736dnk	190	9	widely	widely	RB
cord-321607-3r736dnk	190	10	considered	consider	VBN
cord-321607-3r736dnk	190	11	to	to	TO
cord-321607-3r736dnk	190	12	be	be	VB
cord-321607-3r736dnk	190	13	a	a	DT
cord-321607-3r736dnk	190	14	cytosolic	cytosolic	JJ
cord-321607-3r736dnk	190	15	protein	protein	NN
cord-321607-3r736dnk	190	16	,	,	,
cord-321607-3r736dnk	190	17	it	-PRON-	PRP
cord-321607-3r736dnk	190	18	is	be	VBZ
cord-321607-3r736dnk	190	19	also	also	RB
cord-321607-3r736dnk	190	20	associated	associate	VBN
cord-321607-3r736dnk	190	21	with	with	IN
cord-321607-3r736dnk	190	22	the	the	DT
cord-321607-3r736dnk	190	23	nucleus	nucleus	NN
cord-321607-3r736dnk	190	24	,	,	,
cord-321607-3r736dnk	190	25	mitochondria	mitochondrion	NNS
cord-321607-3r736dnk	190	26	,	,	,
cord-321607-3r736dnk	190	27	and	and	CC
cord-321607-3r736dnk	190	28	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	190	29	[	[	-LRB-
cord-321607-3r736dnk	190	30	76	76	CD
cord-321607-3r736dnk	190	31	,	,	,
cord-321607-3r736dnk	190	32	[	[	-LRB-
cord-321607-3r736dnk	190	33	110	110	CD
cord-321607-3r736dnk	190	34	]	]	-RRB-
cord-321607-3r736dnk	190	35	[	[	-LRB-
cord-321607-3r736dnk	190	36	111	111	CD
cord-321607-3r736dnk	190	37	]	]	-RRB-
cord-321607-3r736dnk	190	38	[	[	-LRB-
cord-321607-3r736dnk	190	39	112	112	CD
cord-321607-3r736dnk	190	40	]	]	-RRB-
cord-321607-3r736dnk	190	41	.	.	.
cord-321607-3r736dnk	191	1	Although	although	IN
cord-321607-3r736dnk	191	2	RNAs	rna	NNS
cord-321607-3r736dnk	191	3	are	be	VBP
cord-321607-3r736dnk	191	4	accessible	accessible	JJ
cord-321607-3r736dnk	191	5	in	in	IN
cord-321607-3r736dnk	191	6	all	all	DT
cord-321607-3r736dnk	191	7	of	of	IN
cord-321607-3r736dnk	191	8	these	these	DT
cord-321607-3r736dnk	191	9	cellular	cellular	JJ
cord-321607-3r736dnk	191	10	compartments	compartment	NNS
cord-321607-3r736dnk	191	11	,	,	,
cord-321607-3r736dnk	191	12	it	-PRON-	PRP
cord-321607-3r736dnk	191	13	prompts	prompt	VBZ
cord-321607-3r736dnk	191	14	the	the	DT
cord-321607-3r736dnk	191	15	question	question	NN
cord-321607-3r736dnk	191	16	whether	whether	IN
cord-321607-3r736dnk	191	17	there	there	EX
cord-321607-3r736dnk	191	18	are	be	VBP
cord-321607-3r736dnk	191	19	alternative	alternative	JJ
cord-321607-3r736dnk	191	20	functions	function	NNS
cord-321607-3r736dnk	191	21	for	for	IN
cord-321607-3r736dnk	191	22	this	this	DT
cord-321607-3r736dnk	191	23	localization	localization	NN
cord-321607-3r736dnk	191	24	.	.	.
cord-321607-3r736dnk	192	1	Early	early	JJ
cord-321607-3r736dnk	192	2	insights	insight	NNS
cord-321607-3r736dnk	192	3	into	into	IN
cord-321607-3r736dnk	192	4	this	this	DT
cord-321607-3r736dnk	192	5	were	be	VBD
cord-321607-3r736dnk	192	6	provided	provide	VBN
cord-321607-3r736dnk	192	7	by	by	IN
cord-321607-3r736dnk	192	8	the	the	DT
cord-321607-3r736dnk	192	9	1998	1998	CD
cord-321607-3r736dnk	192	10	study	study	NN
cord-321607-3r736dnk	192	11	by	by	IN
cord-321607-3r736dnk	192	12	Tnani	Tnani	NNP
cord-321607-3r736dnk	192	13	et	et	NNP
cord-321607-3r736dnk	192	14	al	al	NNP
cord-321607-3r736dnk	192	15	.	.	.
cord-321607-3r736dnk	193	1	[	[	-LRB-
cord-321607-3r736dnk	193	2	112	112	CD
cord-321607-3r736dnk	193	3	]	]	-RRB-
cord-321607-3r736dnk	193	4	,	,	,
cord-321607-3r736dnk	193	5	in	in	IN
cord-321607-3r736dnk	193	6	which	which	WDT
cord-321607-3r736dnk	193	7	they	-PRON-	PRP
cord-321607-3r736dnk	193	8	used	use	VBD
cord-321607-3r736dnk	193	9	biochemical	biochemical	JJ
cord-321607-3r736dnk	193	10	methods	method	NNS
cord-321607-3r736dnk	193	11	to	to	TO
cord-321607-3r736dnk	193	12	detect	detect	VB
cord-321607-3r736dnk	193	13	RNase	RNase	NNP
cord-321607-3r736dnk	193	14	-	-	HYPH
cord-321607-3r736dnk	193	15	L	l	NN
cord-321607-3r736dnk	193	16	in	in	IN
cord-321607-3r736dnk	193	17	the	the	DT
cord-321607-3r736dnk	193	18	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	193	19	fraction	fraction	NN
cord-321607-3r736dnk	193	20	of	of	IN
cord-321607-3r736dnk	193	21	cell	cell	NN
cord-321607-3r736dnk	193	22	extracts	extract	NNS
cord-321607-3r736dnk	193	23	.	.	.
cord-321607-3r736dnk	194	1	They	-PRON-	PRP
cord-321607-3r736dnk	194	2	demonstrated	demonstrate	VBD
cord-321607-3r736dnk	194	3	that	that	IN
cord-321607-3r736dnk	194	4	RNase	RNase	NNP
cord-321607-3r736dnk	194	5	-	-	HYPH
cord-321607-3r736dnk	194	6	L	l	NN
cord-321607-3r736dnk	194	7	associated	associate	VBN
cord-321607-3r736dnk	194	8	with	with	IN
cord-321607-3r736dnk	194	9	the	the	DT
cord-321607-3r736dnk	194	10	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	194	11	in	in	IN
cord-321607-3r736dnk	194	12	a	a	DT
cord-321607-3r736dnk	194	13	conformation	conformation	NN
cord-321607-3r736dnk	194	14	that	that	WDT
cord-321607-3r736dnk	194	15	did	do	VBD
cord-321607-3r736dnk	194	16	not	not	RB
cord-321607-3r736dnk	194	17	allow	allow	VB
cord-321607-3r736dnk	194	18	it	-PRON-	PRP
cord-321607-3r736dnk	194	19	to	to	TO
cord-321607-3r736dnk	194	20	bind	bind	VB
cord-321607-3r736dnk	194	21	2	2	CD
cord-321607-3r736dnk	194	22	-	-	HYPH
cord-321607-3r736dnk	194	23	5A	5a	NN
cord-321607-3r736dnk	194	24	,	,	,
cord-321607-3r736dnk	194	25	which	which	WDT
cord-321607-3r736dnk	194	26	supports	support	VBZ
cord-321607-3r736dnk	194	27	a	a	DT
cord-321607-3r736dnk	194	28	model	model	NN
cord-321607-3r736dnk	194	29	in	in	IN
cord-321607-3r736dnk	194	30	which	which	WDT
cord-321607-3r736dnk	194	31	cytoskeletal	cytoskeletal	NNP
cord-321607-3r736dnk	194	32	association	association	NNP
cord-321607-3r736dnk	194	33	is	be	VBZ
cord-321607-3r736dnk	194	34	incompatible	incompatible	JJ
cord-321607-3r736dnk	194	35	with	with	IN
cord-321607-3r736dnk	194	36	RNase	RNase	NNP
cord-321607-3r736dnk	194	37	-	-	HYPH
cord-321607-3r736dnk	194	38	L	l	NN
cord-321607-3r736dnk	194	39	activity	activity	NN
cord-321607-3r736dnk	194	40	.	.	.
cord-321607-3r736dnk	195	1	Indeed	indeed	RB
cord-321607-3r736dnk	195	2	,	,	,
cord-321607-3r736dnk	195	3	it	-PRON-	PRP
cord-321607-3r736dnk	195	4	is	be	VBZ
cord-321607-3r736dnk	195	5	not	not	RB
cord-321607-3r736dnk	195	6	surprising	surprising	JJ
cord-321607-3r736dnk	195	7	that	that	IN
cord-321607-3r736dnk	195	8	the	the	DT
cord-321607-3r736dnk	195	9	dramatic	dramatic	JJ
cord-321607-3r736dnk	195	10	structural	structural	JJ
cord-321607-3r736dnk	195	11	changes	change	NNS
cord-321607-3r736dnk	195	12	that	that	WDT
cord-321607-3r736dnk	195	13	occur	occur	VBP
cord-321607-3r736dnk	195	14	upon	upon	IN
cord-321607-3r736dnk	195	15	RNase	RNase	NNP
cord-321607-3r736dnk	195	16	-	-	HYPH
cord-321607-3r736dnk	195	17	L	l	NN
cord-321607-3r736dnk	195	18	activation	activation	NN
cord-321607-3r736dnk	195	19	would	would	MD
cord-321607-3r736dnk	195	20	impact	impact	VB
cord-321607-3r736dnk	195	21	its	-PRON-	PRP$
cord-321607-3r736dnk	195	22	interactions	interaction	NNS
cord-321607-3r736dnk	195	23	with	with	IN
cord-321607-3r736dnk	195	24	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	195	25	components	component	NNS
cord-321607-3r736dnk	195	26	.	.	.
cord-321607-3r736dnk	196	1	Treatment	treatment	NN
cord-321607-3r736dnk	196	2	with	with	IN
cord-321607-3r736dnk	196	3	PMA	PMA	NNP
cord-321607-3r736dnk	196	4	,	,	,
cord-321607-3r736dnk	196	5	a	a	DT
cord-321607-3r736dnk	196	6	known	know	VBN
cord-321607-3r736dnk	196	7	inducer	inducer	NN
cord-321607-3r736dnk	196	8	of	of	IN
cord-321607-3r736dnk	196	9	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	196	10	alterations	alteration	NNS
cord-321607-3r736dnk	196	11	,	,	,
cord-321607-3r736dnk	196	12	dissociated	dissociate	VBN
cord-321607-3r736dnk	196	13	RNase	RNase	NNP
cord-321607-3r736dnk	196	14	-	-	HYPH
cord-321607-3r736dnk	196	15	L	l	NN
cord-321607-3r736dnk	196	16	from	from	IN
cord-321607-3r736dnk	196	17	the	the	DT
cord-321607-3r736dnk	196	18	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	196	19	and	and	CC
cord-321607-3r736dnk	196	20	corresponded	correspond	VBD
cord-321607-3r736dnk	196	21	with	with	IN
cord-321607-3r736dnk	196	22	its	-PRON-	PRP$
cord-321607-3r736dnk	196	23	phosphorylation	phosphorylation	NN
cord-321607-3r736dnk	196	24	by	by	IN
cord-321607-3r736dnk	196	25	protein	protein	NN
cord-321607-3r736dnk	196	26	kinase	kinase	NN
cord-321607-3r736dnk	196	27	C	C	NNP
cord-321607-3r736dnk	196	28	(	(	-LRB-
cord-321607-3r736dnk	196	29	PKC	PKC	NNP
cord-321607-3r736dnk	196	30	)	)	-RRB-
cord-321607-3r736dnk	196	31	[	[	-LRB-
cord-321607-3r736dnk	196	32	112	112	CD
cord-321607-3r736dnk	196	33	]	]	-RRB-
cord-321607-3r736dnk	196	34	[	[	-LRB-
cord-321607-3r736dnk	196	35	113	113	CD
cord-321607-3r736dnk	196	36	]	]	-RRB-
cord-321607-3r736dnk	196	37	[	[	-LRB-
cord-321607-3r736dnk	196	38	114	114	CD
cord-321607-3r736dnk	196	39	]	]	-RRB-
cord-321607-3r736dnk	196	40	.	.	.
cord-321607-3r736dnk	197	1	Thus	thus	RB
cord-321607-3r736dnk	197	2	,	,	,
cord-321607-3r736dnk	197	3	changes	change	NNS
cord-321607-3r736dnk	197	4	in	in	IN
cord-321607-3r736dnk	197	5	cell	cell	NN
cord-321607-3r736dnk	197	6	structure	structure	NN
cord-321607-3r736dnk	197	7	may	may	MD
cord-321607-3r736dnk	197	8	induce	induce	VB
cord-321607-3r736dnk	197	9	the	the	DT
cord-321607-3r736dnk	197	10	phosphorylation	phosphorylation	NN
cord-321607-3r736dnk	197	11	of	of	IN
cord-321607-3r736dnk	197	12	RNase	RNase	NNP
cord-321607-3r736dnk	197	13	-	-	HYPH
cord-321607-3r736dnk	197	14	L	L	NNP
cord-321607-3r736dnk	197	15	as	as	IN
cord-321607-3r736dnk	197	16	a	a	DT
cord-321607-3r736dnk	197	17	mechanism	mechanism	NN
cord-321607-3r736dnk	197	18	to	to	TO
cord-321607-3r736dnk	197	19	promote	promote	VB
cord-321607-3r736dnk	197	20	its	-PRON-	PRP$
cord-321607-3r736dnk	197	21	release	release	NN
cord-321607-3r736dnk	197	22	from	from	IN
cord-321607-3r736dnk	197	23	the	the	DT
cord-321607-3r736dnk	197	24	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	197	25	or	or	CC
cord-321607-3r736dnk	197	26	induce	induce	VB
cord-321607-3r736dnk	197	27	conformational	conformational	JJ
cord-321607-3r736dnk	197	28	changes	change	NNS
cord-321607-3r736dnk	197	29	that	that	WDT
cord-321607-3r736dnk	197	30	enable	enable	VBP
cord-321607-3r736dnk	197	31	activation	activation	NN
cord-321607-3r736dnk	197	32	[	[	-LRB-
cord-321607-3r736dnk	197	33	61	61	CD
cord-321607-3r736dnk	197	34	,	,	,
cord-321607-3r736dnk	197	35	112	112	CD
cord-321607-3r736dnk	197	36	]	]	-RRB-
cord-321607-3r736dnk	197	37	.	.	.
cord-321607-3r736dnk	198	1	This	this	DT
cord-321607-3r736dnk	198	2	would	would	MD
cord-321607-3r736dnk	198	3	suggest	suggest	VB
cord-321607-3r736dnk	198	4	a	a	DT
cord-321607-3r736dnk	198	5	model	model	NN
cord-321607-3r736dnk	198	6	in	in	IN
cord-321607-3r736dnk	198	7	which	which	WDT
cord-321607-3r736dnk	198	8	RNase	RNase	NNP
cord-321607-3r736dnk	198	9	-	-	HYPH
cord-321607-3r736dnk	198	10	L	L	NNP
cord-321607-3r736dnk	198	11	bound	bind	VBN
cord-321607-3r736dnk	198	12	to	to	IN
cord-321607-3r736dnk	198	13	the	the	DT
cord-321607-3r736dnk	198	14	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	198	15	is	be	VBZ
cord-321607-3r736dnk	198	16	inactive	inactive	JJ
cord-321607-3r736dnk	198	17	,	,	,
cord-321607-3r736dnk	198	18	however	however	RB
cord-321607-3r736dnk	198	19	,	,	,
cord-321607-3r736dnk	198	20	PMA	PMA	NNP
cord-321607-3r736dnk	198	21	or	or	CC
cord-321607-3r736dnk	198	22	the	the	DT
cord-321607-3r736dnk	198	23	subsequent	subsequent	JJ
cord-321607-3r736dnk	198	24	actin	actin	NN
cord-321607-3r736dnk	198	25	reorganization	reorganization	NN
cord-321607-3r736dnk	198	26	may	may	MD
cord-321607-3r736dnk	198	27	disrupt	disrupt	VB
cord-321607-3r736dnk	198	28	this	this	DT
cord-321607-3r736dnk	198	29	association	association	NN
cord-321607-3r736dnk	198	30	so	so	IN
cord-321607-3r736dnk	198	31	that	that	IN
cord-321607-3r736dnk	198	32	it	-PRON-	PRP
cord-321607-3r736dnk	198	33	can	can	MD
cord-321607-3r736dnk	198	34	bind	bind	VB
cord-321607-3r736dnk	198	35	2	2	CD
cord-321607-3r736dnk	198	36	-	-	HYPH
cord-321607-3r736dnk	198	37	5A	5a	NN
cord-321607-3r736dnk	198	38	and	and	CC
cord-321607-3r736dnk	198	39	initiate	initiate	VB
cord-321607-3r736dnk	198	40	downstream	downstream	RB
cord-321607-3r736dnk	198	41	signaling	signal	VBG
cord-321607-3r736dnk	198	42	and	and	CC
cord-321607-3r736dnk	198	43	effector	effector	NN
cord-321607-3r736dnk	198	44	functions	function	NNS
cord-321607-3r736dnk	198	45	.	.	.
cord-321607-3r736dnk	199	1	More	more	RBR
cord-321607-3r736dnk	199	2	recently	recently	RB
cord-321607-3r736dnk	199	3	,	,	,
cord-321607-3r736dnk	199	4	Gupta	Gupta	NNP
cord-321607-3r736dnk	199	5	et	et	NNP
cord-321607-3r736dnk	199	6	al	al	NNP
cord-321607-3r736dnk	199	7	.	.	.
cord-321607-3r736dnk	200	1	[	[	-LRB-
cord-321607-3r736dnk	200	2	111	111	CD
cord-321607-3r736dnk	200	3	]	]	-RRB-
cord-321607-3r736dnk	200	4	performed	perform	VBD
cord-321607-3r736dnk	200	5	a	a	DT
cord-321607-3r736dnk	200	6	proteomic	proteomic	JJ
cord-321607-3r736dnk	200	7	analysis	analysis	NN
cord-321607-3r736dnk	200	8	of	of	IN
cord-321607-3r736dnk	200	9	RNase	RNase	NNP
cord-321607-3r736dnk	200	10	-	-	HYPH
cord-321607-3r736dnk	200	11	L	l	NN
cord-321607-3r736dnk	200	12	binding	binding	NN
cord-321607-3r736dnk	200	13	proteins	protein	NNS
cord-321607-3r736dnk	200	14	and	and	CC
cord-321607-3r736dnk	200	15	found	find	VBD
cord-321607-3r736dnk	200	16	that	that	IN
cord-321607-3r736dnk	200	17	over	over	IN
cord-321607-3r736dnk	200	18	50	50	CD
cord-321607-3r736dnk	200	19	%	%	NN
cord-321607-3r736dnk	200	20	of	of	IN
cord-321607-3r736dnk	200	21	those	those	DT
cord-321607-3r736dnk	200	22	identified	identify	VBN
cord-321607-3r736dnk	200	23	were	be	VBD
cord-321607-3r736dnk	200	24	involved	involve	VBN
cord-321607-3r736dnk	200	25	in	in	IN
cord-321607-3r736dnk	200	26	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	200	27	and	and	CC
cord-321607-3r736dnk	200	28	motor	motor	NN
cord-321607-3r736dnk	200	29	assembly	assembly	NN
cord-321607-3r736dnk	200	30	.	.	.
cord-321607-3r736dnk	201	1	These	these	DT
cord-321607-3r736dnk	201	2	included	include	VBD
cord-321607-3r736dnk	201	3	β	β	NN
cord-321607-3r736dnk	201	4	-	-	HYPH
cord-321607-3r736dnk	201	5	actin	actin	JJ
cord-321607-3r736dnk	201	6	,	,	,
cord-321607-3r736dnk	201	7	troponin	troponin	JJ
cord-321607-3r736dnk	201	8	I	-PRON-	PRP
cord-321607-3r736dnk	201	9	,	,	,
cord-321607-3r736dnk	201	10	myosin	myosin	NN
cord-321607-3r736dnk	201	11	heavy	heavy	JJ
cord-321607-3r736dnk	201	12	chain	chain	NN
cord-321607-3r736dnk	201	13	9	9	CD
cord-321607-3r736dnk	201	14	,	,	,
cord-321607-3r736dnk	201	15	fibronectin	fibronectin	NN
cord-321607-3r736dnk	201	16	precursor	precursor	NN
cord-321607-3r736dnk	201	17	and	and	CC
cord-321607-3r736dnk	201	18	an	an	DT
cord-321607-3r736dnk	201	19	uncharacterized	uncharacterized	JJ
cord-321607-3r736dnk	201	20	protein	protein	NN
cord-321607-3r736dnk	201	21	with	with	IN
cord-321607-3r736dnk	201	22	homology	homology	NN
cord-321607-3r736dnk	201	23	to	to	IN
cord-321607-3r736dnk	201	24	myosin	myosin	NN
cord-321607-3r736dnk	201	25	binding	bind	VBG
cord-321607-3r736dnk	201	26	protein	protein	NN
cord-321607-3r736dnk	201	27	C	C	NNP
cord-321607-3r736dnk	201	28	,	,	,
cord-321607-3r736dnk	201	29	slow	slow	JJ
cord-321607-3r736dnk	201	30	type	type	NN
cord-321607-3r736dnk	201	31	isoform	isoform	NN
cord-321607-3r736dnk	201	32	CRA_j	CRA_j	NNP
cord-321607-3r736dnk	201	33	.	.	.
cord-321607-3r736dnk	202	1	In	in	IN
cord-321607-3r736dnk	202	2	addition	addition	NN
cord-321607-3r736dnk	202	3	to	to	IN
cord-321607-3r736dnk	202	4	this	this	DT
cord-321607-3r736dnk	202	5	screen	screen	NN
cord-321607-3r736dnk	202	6	,	,	,
cord-321607-3r736dnk	202	7	three	three	CD
cord-321607-3r736dnk	202	8	additional	additional	JJ
cord-321607-3r736dnk	202	9	interacting	interact	VBG
cord-321607-3r736dnk	202	10	proteins	protein	NNS
cord-321607-3r736dnk	202	11	have	have	VBP
cord-321607-3r736dnk	202	12	been	be	VBN
cord-321607-3r736dnk	202	13	more	more	RBR
cord-321607-3r736dnk	202	14	fully	fully	RB
cord-321607-3r736dnk	202	15	characterized	characterize	VBN
cord-321607-3r736dnk	202	16	and	and	CC
cord-321607-3r736dnk	202	17	contribute	contribute	VB
cord-321607-3r736dnk	202	18	towards	towards	IN
cord-321607-3r736dnk	202	19	a	a	DT
cord-321607-3r736dnk	202	20	new	new	JJ
cord-321607-3r736dnk	202	21	model	model	NN
cord-321607-3r736dnk	202	22	of	of	IN
cord-321607-3r736dnk	202	23	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	202	24	-	-	HYPH
cord-321607-3r736dnk	202	25	associated	associate	VBN
cord-321607-3r736dnk	202	26	RNase	RNase	NNP
cord-321607-3r736dnk	202	27	-	-	HYPH
cord-321607-3r736dnk	202	28	L	l	NN
cord-321607-3r736dnk	202	29	activity	activity	NN
cord-321607-3r736dnk	202	30	.	.	.
cord-321607-3r736dnk	203	1	The	the	DT
cord-321607-3r736dnk	203	2	first	first	JJ
cord-321607-3r736dnk	203	3	of	of	IN
cord-321607-3r736dnk	203	4	these	these	DT
cord-321607-3r736dnk	203	5	interacting	interact	VBG
cord-321607-3r736dnk	203	6	partners	partner	NNS
cord-321607-3r736dnk	203	7	is	be	VBZ
cord-321607-3r736dnk	203	8	a	a	DT
cord-321607-3r736dnk	203	9	scaffold	scaffold	NN
cord-321607-3r736dnk	203	10	protein	protein	NN
cord-321607-3r736dnk	203	11	involved	involve	VBN
cord-321607-3r736dnk	203	12	in	in	IN
cord-321607-3r736dnk	203	13	actin	actin	NN
cord-321607-3r736dnk	203	14	reorganization	reorganization	NN
cord-321607-3r736dnk	203	15	,	,	,
cord-321607-3r736dnk	203	16	identified	identify	VBN
cord-321607-3r736dnk	203	17	as	as	IN
cord-321607-3r736dnk	203	18	the	the	DT
cord-321607-3r736dnk	203	19	isoleucine	isoleucine	NN
cord-321607-3r736dnk	203	20	-	-	HYPH
cord-321607-3r736dnk	203	21	glutamine	glutamine	NN
cord-321607-3r736dnk	203	22	(	(	-LRB-
cord-321607-3r736dnk	203	23	IQ	iq	NN
cord-321607-3r736dnk	203	24	)	)	-RRB-
cord-321607-3r736dnk	203	25	motif	motif	NN
cord-321607-3r736dnk	203	26	-	-	HYPH
cord-321607-3r736dnk	203	27	containing	contain	VBG
cord-321607-3r736dnk	203	28	Ras	Ras	NNP
cord-321607-3r736dnk	203	29	GTPase	GTPase	NNP
cord-321607-3r736dnk	203	30	-	-	HYPH
cord-321607-3r736dnk	203	31	activating	activate	VBG
cord-321607-3r736dnk	203	32	-	-	HYPH
cord-321607-3r736dnk	203	33	like	like	JJ
cord-321607-3r736dnk	203	34	protein	protein	NN
cord-321607-3r736dnk	203	35	1	1	CD
cord-321607-3r736dnk	203	36	,	,	,
cord-321607-3r736dnk	203	37	or	or	CC
cord-321607-3r736dnk	203	38	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	203	39	.	.	.
cord-321607-3r736dnk	204	1	IQGAP1	IQGAP1	NNP
cord-321607-3r736dnk	204	2	is	be	VBZ
cord-321607-3r736dnk	204	3	a	a	DT
cord-321607-3r736dnk	204	4	190	190	CD
cord-321607-3r736dnk	204	5	kDa	kDa	NNS
cord-321607-3r736dnk	204	6	,	,	,
cord-321607-3r736dnk	204	7	ubiquitously	ubiquitously	RB
cord-321607-3r736dnk	204	8	expressed	express	VBD
cord-321607-3r736dnk	204	9	protein	protein	NN
cord-321607-3r736dnk	204	10	that	that	WDT
cord-321607-3r736dnk	204	11	shares	share	VBZ
cord-321607-3r736dnk	204	12	a	a	DT
cord-321607-3r736dnk	204	13	number	number	NN
cord-321607-3r736dnk	204	14	of	of	IN
cord-321607-3r736dnk	204	15	biological	biological	JJ
cord-321607-3r736dnk	204	16	functions	function	NNS
cord-321607-3r736dnk	204	17	with	with	IN
cord-321607-3r736dnk	204	18	RNase	RNase	NNP
cord-321607-3r736dnk	204	19	-	-	HYPH
cord-321607-3r736dnk	204	20	L	L	NNP
cord-321607-3r736dnk	204	21	,	,	,
cord-321607-3r736dnk	204	22	including	include	VBG
cord-321607-3r736dnk	204	23	the	the	DT
cord-321607-3r736dnk	204	24	regulation	regulation	NN
cord-321607-3r736dnk	204	25	of	of	IN
cord-321607-3r736dnk	204	26	migration	migration	NN
cord-321607-3r736dnk	204	27	,	,	,
cord-321607-3r736dnk	204	28	proliferation	proliferation	NN
cord-321607-3r736dnk	204	29	,	,	,
cord-321607-3r736dnk	204	30	and	and	CC
cord-321607-3r736dnk	204	31	differentiation	differentiation	NN
cord-321607-3r736dnk	204	32	.	.	.
cord-321607-3r736dnk	205	1	In	in	IN
cord-321607-3r736dnk	205	2	addition	addition	NN
cord-321607-3r736dnk	205	3	,	,	,
cord-321607-3r736dnk	205	4	both	both	DT
cord-321607-3r736dnk	205	5	proteins	protein	NNS
cord-321607-3r736dnk	205	6	regulate	regulate	VBP
cord-321607-3r736dnk	205	7	the	the	DT
cord-321607-3r736dnk	205	8	formation	formation	NN
cord-321607-3r736dnk	205	9	of	of	IN
cord-321607-3r736dnk	205	10	tight	tight	JJ
cord-321607-3r736dnk	205	11	junctions	junction	NNS
cord-321607-3r736dnk	205	12	(	(	-LRB-
cord-321607-3r736dnk	205	13	TJ	TJ	NNP
cord-321607-3r736dnk	205	14	)	)	-RRB-
cord-321607-3r736dnk	205	15	.	.	.
cord-321607-3r736dnk	206	1	IQGAP1	IQGAP1	NNP
cord-321607-3r736dnk	206	2	alters	alter	VBZ
cord-321607-3r736dnk	206	3	TJ	TJ	NNP
cord-321607-3r736dnk	206	4	assembly	assembly	NN
cord-321607-3r736dnk	206	5	by	by	IN
cord-321607-3r736dnk	206	6	reducing	reduce	VBG
cord-321607-3r736dnk	206	7	the	the	DT
cord-321607-3r736dnk	206	8	recruitment	recruitment	NN
cord-321607-3r736dnk	206	9	of	of	IN
cord-321607-3r736dnk	206	10	claudin	claudin	NNP
cord-321607-3r736dnk	206	11	2	2	CD
cord-321607-3r736dnk	206	12	and	and	CC
cord-321607-3r736dnk	206	13	increasing	increase	VBG
cord-321607-3r736dnk	206	14	the	the	DT
cord-321607-3r736dnk	206	15	assembly	assembly	NN
cord-321607-3r736dnk	206	16	of	of	IN
cord-321607-3r736dnk	206	17	claudin	claudin	NNP
cord-321607-3r736dnk	206	18	4	4	CD
cord-321607-3r736dnk	206	19	into	into	IN
cord-321607-3r736dnk	206	20	TJ	TJ	NNP
cord-321607-3r736dnk	206	21	complexes	complex	NNS
cord-321607-3r736dnk	206	22	.	.	.
cord-321607-3r736dnk	207	1	It	-PRON-	PRP
cord-321607-3r736dnk	207	2	also	also	RB
cord-321607-3r736dnk	207	3	diminishes	diminish	VBZ
cord-321607-3r736dnk	207	4	barrier	barrier	NN
cord-321607-3r736dnk	207	5	function	function	NN
cord-321607-3r736dnk	207	6	by	by	IN
cord-321607-3r736dnk	207	7	inhibiting	inhibit	VBG
cord-321607-3r736dnk	207	8	the	the	DT
cord-321607-3r736dnk	207	9	Cdc42-JNK	Cdc42-JNK	NNP
cord-321607-3r736dnk	207	10	signaling	signal	VBG
cord-321607-3r736dnk	207	11	pathway	pathway	NN
cord-321607-3r736dnk	207	12	[	[	-LRB-
cord-321607-3r736dnk	207	13	115	115	CD
cord-321607-3r736dnk	207	14	]	]	-RRB-
cord-321607-3r736dnk	207	15	.	.	.
cord-321607-3r736dnk	208	1	Conversely	conversely	RB
cord-321607-3r736dnk	208	2	,	,	,
cord-321607-3r736dnk	208	3	RNase	RNase	NNP
cord-321607-3r736dnk	208	4	-	-	HYPH
cord-321607-3r736dnk	208	5	L	L	NNP
cord-321607-3r736dnk	208	6	promotes	promote	VBZ
cord-321607-3r736dnk	208	7	the	the	DT
cord-321607-3r736dnk	208	8	expression	expression	NN
cord-321607-3r736dnk	208	9	of	of	IN
cord-321607-3r736dnk	208	10	TJ	TJ	NNP
cord-321607-3r736dnk	208	11	proteins	protein	NNS
cord-321607-3r736dnk	208	12	claudin	claudin	NNP
cord-321607-3r736dnk	208	13	1	1	CD
cord-321607-3r736dnk	208	14	and	and	CC
cord-321607-3r736dnk	208	15	occludin	occludin	NNP
cord-321607-3r736dnk	208	16	,	,	,
cord-321607-3r736dnk	208	17	enhances	enhance	VBZ
cord-321607-3r736dnk	208	18	barrier	barrier	NN
cord-321607-3r736dnk	208	19	function	function	NN
cord-321607-3r736dnk	208	20	,	,	,
cord-321607-3r736dnk	208	21	and	and	CC
cord-321607-3r736dnk	208	22	prevents	prevent	VBZ
cord-321607-3r736dnk	208	23	the	the	DT
cord-321607-3r736dnk	208	24	transepithelial	transepithelial	JJ
cord-321607-3r736dnk	208	25	migration	migration	NN
cord-321607-3r736dnk	208	26	of	of	IN
cord-321607-3r736dnk	208	27	pathogens	pathogen	NNS
cord-321607-3r736dnk	208	28	such	such	JJ
cord-321607-3r736dnk	208	29	as	as	IN
cord-321607-3r736dnk	208	30	EPEC	EPEC	NNP
cord-321607-3r736dnk	208	31	[	[	-LRB-
cord-321607-3r736dnk	208	32	84	84	CD
cord-321607-3r736dnk	208	33	]	]	-RRB-
cord-321607-3r736dnk	208	34	.	.	.
cord-321607-3r736dnk	209	1	IQGAP1	IQGAP1	NNP
cord-321607-3r736dnk	209	2	functions	function	NNS
cord-321607-3r736dnk	209	3	as	as	IN
cord-321607-3r736dnk	209	4	a	a	DT
cord-321607-3r736dnk	209	5	multifunctional	multifunctional	JJ
cord-321607-3r736dnk	209	6	scaffolding	scaffolding	NN
cord-321607-3r736dnk	209	7	protein	protein	NN
cord-321607-3r736dnk	209	8	,	,	,
cord-321607-3r736dnk	209	9	involving	involve	VBG
cord-321607-3r736dnk	209	10	interactions	interaction	NNS
cord-321607-3r736dnk	209	11	with	with	IN
cord-321607-3r736dnk	209	12	over	over	IN
cord-321607-3r736dnk	209	13	50	50	CD
cord-321607-3r736dnk	209	14	binding	bind	VBG
cord-321607-3r736dnk	209	15	partners	partner	NNS
cord-321607-3r736dnk	209	16	thus	thus	RB
cord-321607-3r736dnk	209	17	far	far	RB
cord-321607-3r736dnk	209	18	[	[	-LRB-
cord-321607-3r736dnk	209	19	116	116	CD
cord-321607-3r736dnk	209	20	,	,	,
cord-321607-3r736dnk	209	21	117	117	CD
cord-321607-3r736dnk	209	22	]	]	-RRB-
cord-321607-3r736dnk	209	23	.	.	.
cord-321607-3r736dnk	210	1	One	one	CD
cord-321607-3r736dnk	210	2	of	of	IN
cord-321607-3r736dnk	210	3	the	the	DT
cord-321607-3r736dnk	210	4	main	main	JJ
cord-321607-3r736dnk	210	5	roles	role	NNS
cord-321607-3r736dnk	210	6	for	for	IN
cord-321607-3r736dnk	210	7	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	210	8	is	be	VBZ
cord-321607-3r736dnk	210	9	in	in	IN
cord-321607-3r736dnk	210	10	actin	actin	NN
cord-321607-3r736dnk	210	11	polymerization	polymerization	NN
cord-321607-3r736dnk	210	12	.	.	.
cord-321607-3r736dnk	211	1	It	-PRON-	PRP
cord-321607-3r736dnk	211	2	can	can	MD
cord-321607-3r736dnk	211	3	help	help	VB
cord-321607-3r736dnk	211	4	maintain	maintain	VB
cord-321607-3r736dnk	211	5	Cdc42	Cdc42	NNP
cord-321607-3r736dnk	211	6	and	and	CC
cord-321607-3r736dnk	211	7	Rac1	Rac1	NNP
cord-321607-3r736dnk	211	8	in	in	IN
cord-321607-3r736dnk	211	9	their	-PRON-	PRP$
cord-321607-3r736dnk	211	10	active	active	JJ
cord-321607-3r736dnk	211	11	,	,	,
cord-321607-3r736dnk	211	12	GTP	GTP	NNP
cord-321607-3r736dnk	211	13	-	-	HYPH
cord-321607-3r736dnk	211	14	bound	bind	VBN
cord-321607-3r736dnk	211	15	state	state	NN
cord-321607-3r736dnk	211	16	by	by	IN
cord-321607-3r736dnk	211	17	inhibiting	inhibit	VBG
cord-321607-3r736dnk	211	18	GTP	GTP	NNP
cord-321607-3r736dnk	211	19	hydrolysis	hydrolysis	NN
cord-321607-3r736dnk	211	20	.	.	.
cord-321607-3r736dnk	212	1	In	in	IN
cord-321607-3r736dnk	212	2	the	the	DT
cord-321607-3r736dnk	212	3	case	case	NN
cord-321607-3r736dnk	212	4	of	of	IN
cord-321607-3r736dnk	212	5	Cdc42	Cdc42	NNP
cord-321607-3r736dnk	212	6	,	,	,
cord-321607-3r736dnk	212	7	this	this	DT
cord-321607-3r736dnk	212	8	activity	activity	NN
cord-321607-3r736dnk	212	9	keeps	keep	VBZ
cord-321607-3r736dnk	212	10	WASP	WASP	NNP
cord-321607-3r736dnk	213	1	(	(	-LRB-
cord-321607-3r736dnk	213	2	Wiscott	Wiscott	NNP
cord-321607-3r736dnk	213	3	-	-	HYPH
cord-321607-3r736dnk	213	4	Aldrich	Aldrich	NNP
cord-321607-3r736dnk	213	5	syndrome	syndrome	NN
cord-321607-3r736dnk	213	6	protein	protein	NN
cord-321607-3r736dnk	213	7	)	)	-RRB-
cord-321607-3r736dnk	213	8	bound	bind	VBN
cord-321607-3r736dnk	213	9	to	to	IN
cord-321607-3r736dnk	213	10	Cdc42	Cdc42	NNP
cord-321607-3r736dnk	213	11	,	,	,
cord-321607-3r736dnk	213	12	stabilizing	stabilize	VBG
cord-321607-3r736dnk	213	13	it	-PRON-	PRP
cord-321607-3r736dnk	213	14	and	and	CC
cord-321607-3r736dnk	213	15	maintaining	maintain	VBG
cord-321607-3r736dnk	213	16	its	-PRON-	PRP$
cord-321607-3r736dnk	213	17	interactions	interaction	NNS
cord-321607-3r736dnk	213	18	with	with	IN
cord-321607-3r736dnk	213	19	actin	actin	NN
cord-321607-3r736dnk	213	20	-	-	HYPH
cord-321607-3r736dnk	213	21	related	relate	VBN
cord-321607-3r736dnk	213	22	protein	protein	NN
cord-321607-3r736dnk	213	23	2	2	CD
cord-321607-3r736dnk	213	24	and	and	CC
cord-321607-3r736dnk	213	25	3	3	CD
cord-321607-3r736dnk	214	1	(	(	-LRB-
cord-321607-3r736dnk	214	2	Arp2/3	Arp2/3	NNP
cord-321607-3r736dnk	214	3	)	)	-RRB-
cord-321607-3r736dnk	214	4	and	and	CC
cord-321607-3r736dnk	214	5	globular	globular	JJ
cord-321607-3r736dnk	214	6	actin	actin	NN
cord-321607-3r736dnk	214	7	.	.	.
cord-321607-3r736dnk	215	1	This	this	DT
cord-321607-3r736dnk	215	2	preservation	preservation	NN
cord-321607-3r736dnk	215	3	of	of	IN
cord-321607-3r736dnk	215	4	the	the	DT
cord-321607-3r736dnk	215	5	interactions	interaction	NNS
cord-321607-3r736dnk	215	6	enhances	enhance	VBZ
cord-321607-3r736dnk	215	7	actin	actin	NN
cord-321607-3r736dnk	215	8	polymerization	polymerization	NN
cord-321607-3r736dnk	215	9	and	and	CC
cord-321607-3r736dnk	215	10	branching	branch	VBG
cord-321607-3r736dnk	215	11	[	[	-LRB-
cord-321607-3r736dnk	215	12	118	118	CD
cord-321607-3r736dnk	215	13	]	]	-RRB-
cord-321607-3r736dnk	215	14	.	.	.
cord-321607-3r736dnk	216	1	IQGAP1	IQGAP1	NNP
cord-321607-3r736dnk	216	2	was	be	VBD
cord-321607-3r736dnk	216	3	originally	originally	RB
cord-321607-3r736dnk	216	4	identified	identify	VBN
cord-321607-3r736dnk	216	5	as	as	IN
cord-321607-3r736dnk	216	6	an	an	DT
cord-321607-3r736dnk	216	7	RNase	RNase	NNP
cord-321607-3r736dnk	216	8	-	-	HYPH
cord-321607-3r736dnk	216	9	L	l	NN
cord-321607-3r736dnk	216	10	interacting	interact	VBG
cord-321607-3r736dnk	216	11	protein	protein	NN
cord-321607-3r736dnk	216	12	in	in	IN
cord-321607-3r736dnk	216	13	screens	screen	NNS
cord-321607-3r736dnk	216	14	searching	search	VBG
cord-321607-3r736dnk	216	15	for	for	IN
cord-321607-3r736dnk	216	16	a	a	DT
cord-321607-3r736dnk	216	17	mechanism	mechanism	NN
cord-321607-3r736dnk	216	18	for	for	IN
cord-321607-3r736dnk	216	19	RNase	RNase	NNP
cord-321607-3r736dnk	216	20	-	-	HYPH
cord-321607-3r736dnk	216	21	L	l	NN
cord-321607-3r736dnk	216	22	-	-	HYPH
cord-321607-3r736dnk	216	23	mediated	mediate	VBN
cord-321607-3r736dnk	216	24	cell	cell	NN
cord-321607-3r736dnk	216	25	death	death	NN
cord-321607-3r736dnk	216	26	induced	induce	VBN
cord-321607-3r736dnk	216	27	by	by	IN
cord-321607-3r736dnk	216	28	the	the	DT
cord-321607-3r736dnk	216	29	drug	drug	NN
cord-321607-3r736dnk	216	30	1-(3-C	1-(3-c	CD
cord-321607-3r736dnk	216	31	-	-	HYPH
cord-321607-3r736dnk	216	32	thynyl	thynyl	NN
cord-321607-3r736dnk	216	33	-	-	HYPH
cord-321607-3r736dnk	216	34	β	β	NN
cord-321607-3r736dnk	216	35	-	-	HYPH
cord-321607-3r736dnk	216	36	D	D	NNP
cord-321607-3r736dnk	216	37	-	-	HYPH
cord-321607-3r736dnk	216	38	ribo	ribo	NN
cord-321607-3r736dnk	216	39	-	-	HYPH
cord-321607-3r736dnk	216	40	pentofuanosyl	pentofuanosyl	NN
cord-321607-3r736dnk	216	41	)	)	-RRB-
cord-321607-3r736dnk	216	42	cytosine	cytosine	NN
cord-321607-3r736dnk	216	43	(	(	-LRB-
cord-321607-3r736dnk	216	44	ECyd	ECyd	NNP
cord-321607-3r736dnk	216	45	)	)	-RRB-
cord-321607-3r736dnk	216	46	.	.	.
cord-321607-3r736dnk	217	1	ECyd	ECyd	NNP
cord-321607-3r736dnk	217	2	is	be	VBZ
cord-321607-3r736dnk	217	3	a	a	DT
cord-321607-3r736dnk	217	4	cytotoxic	cytotoxic	JJ
cord-321607-3r736dnk	217	5	nucleoside	nucleoside	NN
cord-321607-3r736dnk	217	6	analogue	analogue	NN
cord-321607-3r736dnk	217	7	that	that	WDT
cord-321607-3r736dnk	217	8	is	be	VBZ
cord-321607-3r736dnk	217	9	active	active	JJ
cord-321607-3r736dnk	217	10	against	against	IN
cord-321607-3r736dnk	217	11	cancer	cancer	NN
cord-321607-3r736dnk	217	12	cells	cell	NNS
cord-321607-3r736dnk	217	13	,	,	,
cord-321607-3r736dnk	217	14	and	and	CC
cord-321607-3r736dnk	217	15	both	both	DT
cord-321607-3r736dnk	217	16	RNase	RNase	NNP
cord-321607-3r736dnk	217	17	-	-	HYPH
cord-321607-3r736dnk	217	18	L	l	NN
cord-321607-3r736dnk	217	19	and	and	CC
cord-321607-3r736dnk	217	20	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	217	21	were	be	VBD
cord-321607-3r736dnk	217	22	necessary	necessary	JJ
cord-321607-3r736dnk	217	23	for	for	IN
cord-321607-3r736dnk	217	24	ECyd	ECyd	NNP
cord-321607-3r736dnk	217	25	-	-	HYPH
cord-321607-3r736dnk	217	26	induced	induce	VBN
cord-321607-3r736dnk	217	27	apoptosis	apoptosis	NN
cord-321607-3r736dnk	217	28	in	in	IN
cord-321607-3r736dnk	217	29	human	human	JJ
cord-321607-3r736dnk	217	30	fibrosarcoma	fibrosarcoma	NNS
cord-321607-3r736dnk	217	31	HT1080	HT1080	NNP
cord-321607-3r736dnk	217	32	cells	cell	NNS
cord-321607-3r736dnk	217	33	.	.	.
cord-321607-3r736dnk	218	1	ECyd	ecyd	JJ
cord-321607-3r736dnk	218	2	treatment	treatment	NN
cord-321607-3r736dnk	218	3	enhanced	enhance	VBN
cord-321607-3r736dnk	218	4	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	218	5	interaction	interaction	NN
cord-321607-3r736dnk	218	6	with	with	IN
cord-321607-3r736dnk	218	7	RNase	RNase	NNP
cord-321607-3r736dnk	218	8	-	-	HYPH
cord-321607-3r736dnk	218	9	L	L	NNP
cord-321607-3r736dnk	218	10	,	,	,
cord-321607-3r736dnk	218	11	however	however	RB
cord-321607-3r736dnk	218	12	,	,	,
cord-321607-3r736dnk	218	13	no	no	DT
cord-321607-3r736dnk	218	14	significant	significant	JJ
cord-321607-3r736dnk	218	15	function	function	NN
cord-321607-3r736dnk	218	16	for	for	IN
cord-321607-3r736dnk	218	17	this	this	DT
cord-321607-3r736dnk	218	18	interaction	interaction	NN
cord-321607-3r736dnk	218	19	was	be	VBD
cord-321607-3r736dnk	218	20	determined	determine	VBN
cord-321607-3r736dnk	218	21	[	[	-LRB-
cord-321607-3r736dnk	218	22	119	119	CD
cord-321607-3r736dnk	218	23	,	,	,
cord-321607-3r736dnk	218	24	120	120	CD
cord-321607-3r736dnk	218	25	]	]	-RRB-
cord-321607-3r736dnk	218	26	.	.	.
cord-321607-3r736dnk	219	1	We	-PRON-	PRP
cord-321607-3r736dnk	219	2	recently	recently	RB
cord-321607-3r736dnk	219	3	identified	identify	VBD
cord-321607-3r736dnk	219	4	filamin	filamin	NNP
cord-321607-3r736dnk	219	5	A	A	NNP
cord-321607-3r736dnk	219	6	(	(	-LRB-
cord-321607-3r736dnk	219	7	FLNA	FLNA	NNP
cord-321607-3r736dnk	219	8	)	)	-RRB-
cord-321607-3r736dnk	219	9	,	,	,
cord-321607-3r736dnk	219	10	an	an	DT
cord-321607-3r736dnk	219	11	actin	actin	NN
cord-321607-3r736dnk	219	12	-	-	HYPH
cord-321607-3r736dnk	219	13	binding	bind	VBG
cord-321607-3r736dnk	219	14	protein	protein	NN
cord-321607-3r736dnk	219	15	that	that	WDT
cord-321607-3r736dnk	219	16	functions	function	VBZ
cord-321607-3r736dnk	219	17	as	as	IN
cord-321607-3r736dnk	219	18	a	a	DT
cord-321607-3r736dnk	219	19	scaffold	scaffold	NN
cord-321607-3r736dnk	219	20	linking	link	VBG
cord-321607-3r736dnk	219	21	many	many	JJ
cord-321607-3r736dnk	219	22	diverse	diverse	JJ
cord-321607-3r736dnk	219	23	proteins	protein	NNS
cord-321607-3r736dnk	219	24	to	to	IN
cord-321607-3r736dnk	219	25	the	the	DT
cord-321607-3r736dnk	219	26	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	219	27	,	,	,
cord-321607-3r736dnk	219	28	as	as	IN
cord-321607-3r736dnk	219	29	a	a	DT
cord-321607-3r736dnk	219	30	second	second	JJ
cord-321607-3r736dnk	219	31	RNase	RNase	NNP
cord-321607-3r736dnk	219	32	-	-	HYPH
cord-321607-3r736dnk	219	33	L	l	NN
cord-321607-3r736dnk	219	34	interacting	interact	VBG
cord-321607-3r736dnk	219	35	protein	protein	NN
cord-321607-3r736dnk	219	36	.	.	.
cord-321607-3r736dnk	220	1	This	this	DT
cord-321607-3r736dnk	220	2	interaction	interaction	NN
cord-321607-3r736dnk	220	3	revealed	reveal	VBD
cord-321607-3r736dnk	220	4	a	a	DT
cord-321607-3r736dnk	220	5	novel	novel	JJ
cord-321607-3r736dnk	220	6	biological	biological	JJ
cord-321607-3r736dnk	220	7	function	function	NN
cord-321607-3r736dnk	220	8	for	for	IN
cord-321607-3r736dnk	220	9	RNase	RNase	NNP
cord-321607-3r736dnk	220	10	-	-	HYPH
cord-321607-3r736dnk	220	11	L	l	NN
cord-321607-3r736dnk	220	12	in	in	IN
cord-321607-3r736dnk	220	13	membrane	membrane	NN
cord-321607-3r736dnk	220	14	integrity	integrity	NN
cord-321607-3r736dnk	220	15	and	and	CC
cord-321607-3r736dnk	220	16	was	be	VBD
cord-321607-3r736dnk	220	17	abrogated	abrogate	VBN
cord-321607-3r736dnk	220	18	upon	upon	IN
cord-321607-3r736dnk	220	19	RNase	RNase	NNP
cord-321607-3r736dnk	220	20	-	-	HYPH
cord-321607-3r736dnk	220	21	L	l	NN
cord-321607-3r736dnk	220	22	activation	activation	NN
cord-321607-3r736dnk	220	23	by	by	IN
cord-321607-3r736dnk	220	24	either	either	DT
cord-321607-3r736dnk	220	25	2	2	CD
cord-321607-3r736dnk	220	26	-	-	HYPH
cord-321607-3r736dnk	220	27	5A	5a	NN
cord-321607-3r736dnk	220	28	or	or	CC
cord-321607-3r736dnk	220	29	EMCV	EMCV	NNP
cord-321607-3r736dnk	220	30	infection	infection	NN
cord-321607-3r736dnk	220	31	.	.	.
cord-321607-3r736dnk	221	1	Complex	complex	JJ
cord-321607-3r736dnk	221	2	formation	formation	NN
cord-321607-3r736dnk	221	3	did	do	VBD
cord-321607-3r736dnk	221	4	not	not	RB
cord-321607-3r736dnk	221	5	require	require	VB
cord-321607-3r736dnk	221	6	RNase	RNase	NNP
cord-321607-3r736dnk	221	7	-	-	HYPH
cord-321607-3r736dnk	221	8	L	l	NN
cord-321607-3r736dnk	221	9	nuclease	nuclease	NN
cord-321607-3r736dnk	221	10	or	or	CC
cord-321607-3r736dnk	221	11	dimerization	dimerization	NN
cord-321607-3r736dnk	221	12	functions	function	NNS
cord-321607-3r736dnk	221	13	,	,	,
cord-321607-3r736dnk	221	14	but	but	CC
cord-321607-3r736dnk	221	15	did	do	VBD
cord-321607-3r736dnk	221	16	require	require	VB
cord-321607-3r736dnk	221	17	the	the	DT
cord-321607-3r736dnk	221	18	N	n	CD
cord-321607-3r736dnk	221	19	-	-	HYPH
cord-321607-3r736dnk	221	20	terminal	terminal	NN
cord-321607-3r736dnk	221	21	ankyrin	ankyrin	NNP
cord-321607-3r736dnk	221	22	repeat	repeat	NN
cord-321607-3r736dnk	221	23	domains	domain	NNS
cord-321607-3r736dnk	221	24	.	.	.
cord-321607-3r736dnk	222	1	Other	other	JJ
cord-321607-3r736dnk	222	2	RNase	rnase	NN
cord-321607-3r736dnk	222	3	-	-	HYPH
cord-321607-3r736dnk	222	4	L	l	NN
cord-321607-3r736dnk	222	5	interacting	interact	VBG
cord-321607-3r736dnk	222	6	proteins	protein	NNS
cord-321607-3r736dnk	222	7	have	have	VBP
cord-321607-3r736dnk	222	8	,	,	,
cord-321607-3r736dnk	222	9	somewhat	somewhat	RB
cord-321607-3r736dnk	222	10	surprisingly	surprisingly	RB
cord-321607-3r736dnk	222	11	,	,	,
cord-321607-3r736dnk	222	12	bound	bind	VBN
cord-321607-3r736dnk	222	13	to	to	IN
cord-321607-3r736dnk	222	14	the	the	DT
cord-321607-3r736dnk	222	15	C	C	NNP
cord-321607-3r736dnk	222	16	-	-	HYPH
cord-321607-3r736dnk	222	17	terminus	terminus	NN
cord-321607-3r736dnk	222	18	,	,	,
cord-321607-3r736dnk	222	19	possibly	possibly	RB
cord-321607-3r736dnk	222	20	indicating	indicate	VBG
cord-321607-3r736dnk	222	21	that	that	IN
cord-321607-3r736dnk	222	22	RNase	RNase	NNP
cord-321607-3r736dnk	222	23	-	-	HYPH
cord-321607-3r736dnk	222	24	L	L	NNP
cord-321607-3r736dnk	222	25	may	may	MD
cord-321607-3r736dnk	222	26	bind	bind	VB
cord-321607-3r736dnk	222	27	multiple	multiple	JJ
cord-321607-3r736dnk	222	28	proteins	protein	NNS
cord-321607-3r736dnk	222	29	simultaneously	simultaneously	RB
cord-321607-3r736dnk	222	30	.	.	.
cord-321607-3r736dnk	223	1	In	in	IN
cord-321607-3r736dnk	223	2	addition	addition	NN
cord-321607-3r736dnk	223	3	,	,	,
cord-321607-3r736dnk	223	4	binding	bind	VBG
cord-321607-3r736dnk	223	5	to	to	IN
cord-321607-3r736dnk	223	6	FLNA	FLNA	NNP
cord-321607-3r736dnk	223	7	did	do	VBD
cord-321607-3r736dnk	223	8	not	not	RB
cord-321607-3r736dnk	223	9	inhibit	inhibit	VB
cord-321607-3r736dnk	223	10	or	or	CC
cord-321607-3r736dnk	223	11	enhance	enhance	VB
cord-321607-3r736dnk	223	12	the	the	DT
cord-321607-3r736dnk	223	13	activation	activation	NN
cord-321607-3r736dnk	223	14	or	or	CC
cord-321607-3r736dnk	223	15	nucleolytic	nucleolytic	JJ
cord-321607-3r736dnk	223	16	activities	activity	NNS
cord-321607-3r736dnk	223	17	of	of	IN
cord-321607-3r736dnk	223	18	RNase	RNase	NNP
cord-321607-3r736dnk	223	19	-	-	HYPH
cord-321607-3r736dnk	223	20	L.	L.	NNP
cord-321607-3r736dnk	223	21	Examination	Examination	NNP
cord-321607-3r736dnk	223	22	of	of	IN
cord-321607-3r736dnk	223	23	the	the	DT
cord-321607-3r736dnk	223	24	potential	potential	JJ
cord-321607-3r736dnk	223	25	reciprocal	reciprocal	JJ
cord-321607-3r736dnk	223	26	consequences	consequence	NNS
cord-321607-3r736dnk	223	27	of	of	IN
cord-321607-3r736dnk	223	28	the	the	DT
cord-321607-3r736dnk	223	29	interaction	interaction	NN
cord-321607-3r736dnk	223	30	on	on	IN
cord-321607-3r736dnk	223	31	actin	actin	NN
cord-321607-3r736dnk	223	32	dynamics	dynamic	NNS
cord-321607-3r736dnk	223	33	found	find	VBD
cord-321607-3r736dnk	223	34	that	that	IN
cord-321607-3r736dnk	223	35	RNase	RNase	NNP
cord-321607-3r736dnk	223	36	-	-	HYPH
cord-321607-3r736dnk	223	37	L	L	NNP
cord-321607-3r736dnk	223	38	KO	KO	NNP
cord-321607-3r736dnk	223	39	primary	primary	JJ
cord-321607-3r736dnk	223	40	murine	murine	JJ
cord-321607-3r736dnk	223	41	embryonic	embryonic	JJ
cord-321607-3r736dnk	223	42	fibroblasts	fibroblast	NNS
cord-321607-3r736dnk	223	43	(	(	-LRB-
cord-321607-3r736dnk	223	44	MEFs	MEFs	NNP
cord-321607-3r736dnk	223	45	)	)	-RRB-
cord-321607-3r736dnk	223	46	had	have	VBD
cord-321607-3r736dnk	223	47	a	a	DT
cord-321607-3r736dnk	223	48	30	30	CD
cord-321607-3r736dnk	223	49	%	%	NN
cord-321607-3r736dnk	223	50	reduction	reduction	NN
cord-321607-3r736dnk	223	51	in	in	IN
cord-321607-3r736dnk	223	52	actin	actin	NN
cord-321607-3r736dnk	223	53	filaments	filament	NNS
cord-321607-3r736dnk	223	54	compared	compare	VBN
cord-321607-3r736dnk	223	55	to	to	IN
cord-321607-3r736dnk	223	56	WT	WT	NNP
cord-321607-3r736dnk	223	57	MEFs	mef	NNS
cord-321607-3r736dnk	223	58	.	.	.
cord-321607-3r736dnk	224	1	Further	further	RB
cord-321607-3r736dnk	224	2	probing	probe	VBG
cord-321607-3r736dnk	224	3	into	into	IN
cord-321607-3r736dnk	224	4	this	this	DT
cord-321607-3r736dnk	224	5	role	role	NN
cord-321607-3r736dnk	224	6	for	for	IN
cord-321607-3r736dnk	224	7	RNase	RNase	NNP
cord-321607-3r736dnk	224	8	-	-	HYPH
cord-321607-3r736dnk	224	9	L	l	NN
cord-321607-3r736dnk	224	10	in	in	IN
cord-321607-3r736dnk	224	11	actin	actin	NN
cord-321607-3r736dnk	224	12	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	224	13	function	function	NN
cord-321607-3r736dnk	224	14	demonstrated	demonstrate	VBD
cord-321607-3r736dnk	224	15	that	that	IN
cord-321607-3r736dnk	224	16	RNase	RNase	NNP
cord-321607-3r736dnk	224	17	-	-	HYPH
cord-321607-3r736dnk	224	18	L	L	NNP
cord-321607-3r736dnk	224	19	inhibited	inhibit	VBD
cord-321607-3r736dnk	224	20	the	the	DT
cord-321607-3r736dnk	224	21	endocytosis	endocytosis	NN
cord-321607-3r736dnk	224	22	of	of	IN
cord-321607-3r736dnk	224	23	both	both	CC
cord-321607-3r736dnk	224	24	an	an	DT
cord-321607-3r736dnk	224	25	inert	inert	JJ
cord-321607-3r736dnk	224	26	synthetic	synthetic	JJ
cord-321607-3r736dnk	224	27	agent	agent	NN
cord-321607-3r736dnk	224	28	and	and	CC
cord-321607-3r736dnk	224	29	viral	viral	JJ
cord-321607-3r736dnk	224	30	particles	particle	NNS
cord-321607-3r736dnk	224	31	.	.	.
cord-321607-3r736dnk	225	1	Significantly	significantly	RB
cord-321607-3r736dnk	225	2	,	,	,
cord-321607-3r736dnk	225	3	inhibition	inhibition	NN
cord-321607-3r736dnk	225	4	of	of	IN
cord-321607-3r736dnk	225	5	virus	virus	NN
cord-321607-3r736dnk	225	6	entry	entry	NN
cord-321607-3r736dnk	225	7	was	be	VBD
cord-321607-3r736dnk	225	8	independent	independent	JJ
cord-321607-3r736dnk	225	9	of	of	IN
cord-321607-3r736dnk	225	10	endoribonuclease	endoribonuclease	NNP
cord-321607-3r736dnk	225	11	activity	activity	NN
cord-321607-3r736dnk	225	12	,	,	,
cord-321607-3r736dnk	225	13	providing	provide	VBG
cord-321607-3r736dnk	225	14	the	the	DT
cord-321607-3r736dnk	225	15	first	first	JJ
cord-321607-3r736dnk	225	16	evidence	evidence	NN
cord-321607-3r736dnk	225	17	of	of	IN
cord-321607-3r736dnk	225	18	a	a	DT
cord-321607-3r736dnk	225	19	non	non	JJ
cord-321607-3r736dnk	225	20	-	-	JJ
cord-321607-3r736dnk	225	21	catalytic	catalytic	JJ
cord-321607-3r736dnk	225	22	mechanism	mechanism	NN
cord-321607-3r736dnk	225	23	of	of	IN
cord-321607-3r736dnk	225	24	RNase	RNase	NNP
cord-321607-3r736dnk	225	25	-	-	HYPH
cord-321607-3r736dnk	225	26	L	L	NNP
cord-321607-3r736dnk	225	27	action	action	NN
cord-321607-3r736dnk	225	28	.	.	.
cord-321607-3r736dnk	226	1	All	all	DT
cord-321607-3r736dnk	226	2	other	other	JJ
cord-321607-3r736dnk	226	3	functions	function	NNS
cord-321607-3r736dnk	226	4	for	for	IN
cord-321607-3r736dnk	226	5	RNase	RNase	NNP
cord-321607-3r736dnk	226	6	-	-	HYPH
cord-321607-3r736dnk	226	7	L	L	NNP
cord-321607-3r736dnk	226	8	have	have	VBP
cord-321607-3r736dnk	226	9	been	be	VBN
cord-321607-3r736dnk	226	10	shown	show	VBN
cord-321607-3r736dnk	226	11	,	,	,
cord-321607-3r736dnk	226	12	or	or	CC
cord-321607-3r736dnk	226	13	presumed	presume	VBN
cord-321607-3r736dnk	226	14	to	to	TO
cord-321607-3r736dnk	226	15	be	be	VB
cord-321607-3r736dnk	226	16	the	the	DT
cord-321607-3r736dnk	226	17	result	result	NN
cord-321607-3r736dnk	226	18	of	of	IN
cord-321607-3r736dnk	226	19	RNA	RNA	NNP
cord-321607-3r736dnk	226	20	cleavage	cleavage	NN
cord-321607-3r736dnk	226	21	leading	lead	VBG
cord-321607-3r736dnk	226	22	to	to	IN
cord-321607-3r736dnk	226	23	altered	altered	JJ
cord-321607-3r736dnk	226	24	regulation	regulation	NN
cord-321607-3r736dnk	226	25	of	of	IN
cord-321607-3r736dnk	226	26	gene	gene	NN
cord-321607-3r736dnk	226	27	expression	expression	NN
cord-321607-3r736dnk	226	28	via	via	IN
cord-321607-3r736dnk	226	29	direct	direct	JJ
cord-321607-3r736dnk	226	30	or	or	CC
cord-321607-3r736dnk	226	31	indirect	indirect	JJ
cord-321607-3r736dnk	226	32	degradation	degradation	NN
cord-321607-3r736dnk	226	33	mechanisms	mechanism	NNS
cord-321607-3r736dnk	226	34	[	[	-LRB-
cord-321607-3r736dnk	226	35	25	25	CD
cord-321607-3r736dnk	226	36	]	]	-RRB-
cord-321607-3r736dnk	226	37	.	.	.
cord-321607-3r736dnk	227	1	The	the	DT
cord-321607-3r736dnk	227	2	diminished	diminished	JJ
cord-321607-3r736dnk	227	3	uptake	uptake	NN
cord-321607-3r736dnk	227	4	of	of	IN
cord-321607-3r736dnk	227	5	virus	virus	NN
cord-321607-3r736dnk	227	6	in	in	IN
cord-321607-3r736dnk	227	7	RNase	RNase	NNP
cord-321607-3r736dnk	227	8	-	-	HYPH
cord-321607-3r736dnk	227	9	L	l	NN
cord-321607-3r736dnk	227	10	-	-	HYPH
cord-321607-3r736dnk	227	11	expressing	express	VBG
cord-321607-3r736dnk	227	12	cells	cell	NNS
cord-321607-3r736dnk	227	13	was	be	VBD
cord-321607-3r736dnk	227	14	sufficient	sufficient	JJ
cord-321607-3r736dnk	227	15	to	to	TO
cord-321607-3r736dnk	227	16	inhibit	inhibit	VB
cord-321607-3r736dnk	227	17	overall	overall	JJ
cord-321607-3r736dnk	227	18	virus	virus	NN
cord-321607-3r736dnk	227	19	production	production	NN
cord-321607-3r736dnk	227	20	and	and	CC
cord-321607-3r736dnk	227	21	this	this	DT
cord-321607-3r736dnk	227	22	was	be	VBD
cord-321607-3r736dnk	227	23	complemented	complement	VBN
cord-321607-3r736dnk	227	24	by	by	IN
cord-321607-3r736dnk	227	25	similar	similar	JJ
cord-321607-3r736dnk	227	26	results	result	NNS
cord-321607-3r736dnk	227	27	in	in	IN
cord-321607-3r736dnk	227	28	the	the	DT
cord-321607-3r736dnk	227	29	presence	presence	NN
cord-321607-3r736dnk	227	30	or	or	CC
cord-321607-3r736dnk	227	31	absence	absence	NN
cord-321607-3r736dnk	227	32	of	of	IN
cord-321607-3r736dnk	227	33	FLNA	FLNA	NNP
cord-321607-3r736dnk	227	34	[	[	-LRB-
cord-321607-3r736dnk	227	35	28	28	CD
cord-321607-3r736dnk	227	36	]	]	-RRB-
cord-321607-3r736dnk	227	37	.	.	.
cord-321607-3r736dnk	228	1	These	these	DT
cord-321607-3r736dnk	228	2	data	datum	NNS
cord-321607-3r736dnk	228	3	provide	provide	VBP
cord-321607-3r736dnk	228	4	a	a	DT
cord-321607-3r736dnk	228	5	new	new	JJ
cord-321607-3r736dnk	228	6	model	model	NN
cord-321607-3r736dnk	228	7	for	for	IN
cord-321607-3r736dnk	228	8	RNase	RNase	NNP
cord-321607-3r736dnk	228	9	-	-	HYPH
cord-321607-3r736dnk	228	10	L	l	NN
cord-321607-3r736dnk	228	11	activity	activity	NN
cord-321607-3r736dnk	228	12	as	as	IN
cord-321607-3r736dnk	228	13	a	a	DT
cord-321607-3r736dnk	228	14	structural	structural	JJ
cord-321607-3r736dnk	228	15	component	component	NN
cord-321607-3r736dnk	228	16	of	of	IN
cord-321607-3r736dnk	228	17	the	the	DT
cord-321607-3r736dnk	228	18	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	228	19	barrier	barrier	NN
cord-321607-3r736dnk	228	20	that	that	WDT
cord-321607-3r736dnk	228	21	refracts	refract	VBZ
cord-321607-3r736dnk	228	22	the	the	DT
cord-321607-3r736dnk	228	23	actin	actin	NN
cord-321607-3r736dnk	228	24	reorganization	reorganization	NN
cord-321607-3r736dnk	228	25	involved	involve	VBN
cord-321607-3r736dnk	228	26	in	in	IN
cord-321607-3r736dnk	228	27	the	the	DT
cord-321607-3r736dnk	228	28	endocytosis	endocytosis	NN
cord-321607-3r736dnk	228	29	of	of	IN
cord-321607-3r736dnk	228	30	viral	viral	JJ
cord-321607-3r736dnk	228	31	particles	particle	NNS
cord-321607-3r736dnk	228	32	.	.	.
cord-321607-3r736dnk	229	1	This	this	DT
cord-321607-3r736dnk	229	2	localization	localization	NN
cord-321607-3r736dnk	229	3	may	may	MD
cord-321607-3r736dnk	229	4	also	also	RB
cord-321607-3r736dnk	229	5	place	place	VB
cord-321607-3r736dnk	229	6	RNase	RNase	NNP
cord-321607-3r736dnk	229	7	-	-	HYPH
cord-321607-3r736dnk	229	8	L	l	NN
cord-321607-3r736dnk	229	9	in	in	IN
cord-321607-3r736dnk	229	10	immediate	immediate	JJ
cord-321607-3r736dnk	229	11	proximity	proximity	NN
cord-321607-3r736dnk	229	12	to	to	IN
cord-321607-3r736dnk	229	13	virus	virus	NN
cord-321607-3r736dnk	229	14	that	that	WDT
cord-321607-3r736dnk	229	15	is	be	VBZ
cord-321607-3r736dnk	229	16	able	able	JJ
cord-321607-3r736dnk	229	17	to	to	TO
cord-321607-3r736dnk	229	18	bypass	bypass	VB
cord-321607-3r736dnk	229	19	this	this	DT
cord-321607-3r736dnk	229	20	first	first	JJ
cord-321607-3r736dnk	229	21	layer	layer	NN
cord-321607-3r736dnk	229	22	of	of	IN
cord-321607-3r736dnk	229	23	host	host	NN
cord-321607-3r736dnk	229	24	defense	defense	NN
cord-321607-3r736dnk	229	25	in	in	IN
cord-321607-3r736dnk	229	26	order	order	NN
cord-321607-3r736dnk	229	27	to	to	TO
cord-321607-3r736dnk	229	28	hasten	hasten	VB
cord-321607-3r736dnk	229	29	the	the	DT
cord-321607-3r736dnk	229	30	antiviral	antiviral	JJ
cord-321607-3r736dnk	229	31	response	response	NN
cord-321607-3r736dnk	229	32	via	via	IN
cord-321607-3r736dnk	229	33	its	-PRON-	PRP$
cord-321607-3r736dnk	229	34	canonical	canonical	JJ
cord-321607-3r736dnk	229	35	nuclease	nuclease	NN
cord-321607-3r736dnk	229	36	-	-	HYPH
cord-321607-3r736dnk	229	37	dependent	dependent	JJ
cord-321607-3r736dnk	229	38	functions	function	NNS
cord-321607-3r736dnk	229	39	.	.	.
cord-321607-3r736dnk	230	1	Activation	activation	NN
cord-321607-3r736dnk	230	2	of	of	IN
cord-321607-3r736dnk	230	3	RNase	RNase	NNP
cord-321607-3r736dnk	230	4	-	-	HYPH
cord-321607-3r736dnk	230	5	L	L	NNP
cord-321607-3r736dnk	230	6	may	may	MD
cord-321607-3r736dnk	230	7	then	then	RB
cord-321607-3r736dnk	230	8	cause	cause	VB
cord-321607-3r736dnk	230	9	a	a	DT
cord-321607-3r736dnk	230	10	conformational	conformational	JJ
cord-321607-3r736dnk	230	11	change	change	NN
cord-321607-3r736dnk	230	12	that	that	WDT
cord-321607-3r736dnk	230	13	induces	induce	VBZ
cord-321607-3r736dnk	230	14	its	-PRON-	PRP$
cord-321607-3r736dnk	230	15	release	release	NN
cord-321607-3r736dnk	230	16	from	from	IN
cord-321607-3r736dnk	230	17	FLNA	FLNA	NNP
cord-321607-3r736dnk	230	18	.	.	.
cord-321607-3r736dnk	231	1	Although	although	IN
cord-321607-3r736dnk	231	2	FLNA	FLNA	NNP
cord-321607-3r736dnk	231	3	does	do	VBZ
cord-321607-3r736dnk	231	4	not	not	RB
cord-321607-3r736dnk	231	5	alter	alter	VB
cord-321607-3r736dnk	231	6	the	the	DT
cord-321607-3r736dnk	231	7	capacity	capacity	NN
cord-321607-3r736dnk	231	8	of	of	IN
cord-321607-3r736dnk	231	9	virus	virus	NN
cord-321607-3r736dnk	231	10	to	to	TO
cord-321607-3r736dnk	231	11	activate	activate	VB
cord-321607-3r736dnk	231	12	RNase	RNase	NNP
cord-321607-3r736dnk	231	13	-	-	HYPH
cord-321607-3r736dnk	231	14	L	L	NNP
cord-321607-3r736dnk	231	15	,	,	,
cord-321607-3r736dnk	231	16	the	the	DT
cord-321607-3r736dnk	231	17	interaction	interaction	NN
cord-321607-3r736dnk	231	18	may	may	MD
cord-321607-3r736dnk	231	19	aid	aid	VB
cord-321607-3r736dnk	231	20	in	in	IN
cord-321607-3r736dnk	231	21	preventing	prevent	VBG
cord-321607-3r736dnk	231	22	incidental	incidental	JJ
cord-321607-3r736dnk	231	23	oligomerization	oligomerization	NN
cord-321607-3r736dnk	231	24	of	of	IN
cord-321607-3r736dnk	231	25	latent	latent	JJ
cord-321607-3r736dnk	231	26	RNase	RNase	NNP
cord-321607-3r736dnk	231	27	-	-	HYPH
cord-321607-3r736dnk	231	28	L	l	NN
cord-321607-3r736dnk	231	29	monomer	monomer	NN
cord-321607-3r736dnk	231	30	,	,	,
cord-321607-3r736dnk	231	31	adding	add	VBG
cord-321607-3r736dnk	231	32	to	to	IN
cord-321607-3r736dnk	231	33	the	the	DT
cord-321607-3r736dnk	231	34	many	many	JJ
cord-321607-3r736dnk	231	35	layers	layer	NNS
cord-321607-3r736dnk	231	36	of	of	IN
cord-321607-3r736dnk	231	37	regulation	regulation	NN
cord-321607-3r736dnk	231	38	needed	need	VBN
cord-321607-3r736dnk	231	39	to	to	TO
cord-321607-3r736dnk	231	40	keep	keep	VB
cord-321607-3r736dnk	231	41	RNase	RNase	NNP
cord-321607-3r736dnk	231	42	-	-	HYPH
cord-321607-3r736dnk	231	43	L	l	NN
cord-321607-3r736dnk	231	44	activity	activity	NN
cord-321607-3r736dnk	231	45	in	in	IN
cord-321607-3r736dnk	231	46	check	check	NN
cord-321607-3r736dnk	231	47	.	.	.
cord-321607-3r736dnk	232	1	These	these	DT
cord-321607-3r736dnk	232	2	findings	finding	NNS
cord-321607-3r736dnk	232	3	were	be	VBD
cord-321607-3r736dnk	232	4	the	the	DT
cord-321607-3r736dnk	232	5	first	first	JJ
cord-321607-3r736dnk	232	6	to	to	TO
cord-321607-3r736dnk	232	7	truly	truly	RB
cord-321607-3r736dnk	232	8	characterize	characterize	VB
cord-321607-3r736dnk	232	9	a	a	DT
cord-321607-3r736dnk	232	10	function	function	NN
cord-321607-3r736dnk	232	11	for	for	IN
cord-321607-3r736dnk	232	12	RNase	RNase	NNP
cord-321607-3r736dnk	232	13	-	-	HYPH
cord-321607-3r736dnk	232	14	L	l	NN
cord-321607-3r736dnk	232	15	in	in	IN
cord-321607-3r736dnk	232	16	the	the	DT
cord-321607-3r736dnk	232	17	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	232	18	.	.	.
cord-321607-3r736dnk	233	1	Our	-PRON-	PRP$
cord-321607-3r736dnk	233	2	lab	lab	NN
cord-321607-3r736dnk	233	3	has	have	VBZ
cord-321607-3r736dnk	233	4	also	also	RB
cord-321607-3r736dnk	233	5	identified	identify	VBN
cord-321607-3r736dnk	233	6	a	a	DT
cord-321607-3r736dnk	233	7	third	third	JJ
cord-321607-3r736dnk	233	8	interacting	interact	VBG
cord-321607-3r736dnk	233	9	protein	protein	NN
cord-321607-3r736dnk	233	10	that	that	WDT
cord-321607-3r736dnk	233	11	links	link	VBZ
cord-321607-3r736dnk	233	12	RNase	RNase	NNP
cord-321607-3r736dnk	233	13	-	-	HYPH
cord-321607-3r736dnk	233	14	L	l	NN
cord-321607-3r736dnk	233	15	to	to	IN
cord-321607-3r736dnk	233	16	the	the	DT
cord-321607-3r736dnk	233	17	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	233	18	,	,	,
cord-321607-3r736dnk	233	19	the	the	DT
cord-321607-3r736dnk	233	20	ligand	ligand	NN
cord-321607-3r736dnk	233	21	of	of	IN
cord-321607-3r736dnk	233	22	numb	numb	JJ
cord-321607-3r736dnk	233	23	protein	protein	NN
cord-321607-3r736dnk	233	24	X-1	x-1	NN
cord-321607-3r736dnk	233	25	(	(	-LRB-
cord-321607-3r736dnk	233	26	LNX	LNX	NNP
cord-321607-3r736dnk	233	27	)	)	-RRB-
cord-321607-3r736dnk	233	28	.	.	.
cord-321607-3r736dnk	234	1	LNX	LNX	NNP
cord-321607-3r736dnk	234	2	is	be	VBZ
cord-321607-3r736dnk	234	3	a	a	DT
cord-321607-3r736dnk	234	4	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	234	5	/	/	SYM
cord-321607-3r736dnk	234	6	TJ	TJ	NNP
cord-321607-3r736dnk	234	7	-	-	HYPH
cord-321607-3r736dnk	234	8	associated	associate	VBN
cord-321607-3r736dnk	234	9	protein	protein	NN
cord-321607-3r736dnk	234	10	that	that	WDT
cord-321607-3r736dnk	234	11	was	be	VBD
cord-321607-3r736dnk	234	12	isolated	isolate	VBN
cord-321607-3r736dnk	234	13	through	through	IN
cord-321607-3r736dnk	234	14	a	a	DT
cord-321607-3r736dnk	234	15	yeast	yeast	NN
cord-321607-3r736dnk	234	16	two	two	CD
cord-321607-3r736dnk	234	17	-	-	HYPH
cord-321607-3r736dnk	234	18	hybrid	hybrid	NN
cord-321607-3r736dnk	234	19	screen	screen	NN
cord-321607-3r736dnk	234	20	using	use	VBG
cord-321607-3r736dnk	234	21	RNase	RNase	NNP
cord-321607-3r736dnk	234	22	-	-	HYPH
cord-321607-3r736dnk	234	23	L	L	NNP
cord-321607-3r736dnk	234	24	as	as	IN
cord-321607-3r736dnk	234	25	bait	bait	NN
cord-321607-3r736dnk	234	26	.	.	.
cord-321607-3r736dnk	235	1	LNX	LNX	NNP
cord-321607-3r736dnk	235	2	is	be	VBZ
cord-321607-3r736dnk	235	3	an	an	DT
cord-321607-3r736dnk	235	4	E3	e3	NN
cord-321607-3r736dnk	235	5	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	235	6	ligase	ligase	NN
cord-321607-3r736dnk	235	7	that	that	WDT
cord-321607-3r736dnk	235	8	contains	contain	VBZ
cord-321607-3r736dnk	235	9	a	a	DT
cord-321607-3r736dnk	235	10	RING	ring	NN
cord-321607-3r736dnk	235	11	finger	finger	NN
cord-321607-3r736dnk	235	12	in	in	IN
cord-321607-3r736dnk	235	13	its	-PRON-	PRP$
cord-321607-3r736dnk	235	14	N	n	CD
cord-321607-3r736dnk	235	15	-	-	HYPH
cord-321607-3r736dnk	235	16	terminus	terminus	NN
cord-321607-3r736dnk	235	17	,	,	,
cord-321607-3r736dnk	235	18	which	which	WDT
cord-321607-3r736dnk	235	19	mediates	mediate	VBZ
cord-321607-3r736dnk	235	20	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	235	21	ligase	ligase	NN
cord-321607-3r736dnk	235	22	activity	activity	NN
cord-321607-3r736dnk	235	23	,	,	,
cord-321607-3r736dnk	235	24	and	and	CC
cord-321607-3r736dnk	235	25	four	four	CD
cord-321607-3r736dnk	235	26	PDZ	PDZ	NNP
cord-321607-3r736dnk	235	27	domains	domain	NNS
cord-321607-3r736dnk	235	28	(	(	-LRB-
cord-321607-3r736dnk	235	29	named	name	VBN
cord-321607-3r736dnk	235	30	after	after	IN
cord-321607-3r736dnk	235	31	the	the	DT
cord-321607-3r736dnk	235	32	proteins	protein	NNS
cord-321607-3r736dnk	235	33	postsynaptic	postsynaptic	JJ
cord-321607-3r736dnk	235	34	density	density	NN
cord-321607-3r736dnk	235	35	95	95	CD
cord-321607-3r736dnk	235	36	,	,	,
cord-321607-3r736dnk	235	37	Drosophila	Drosophila	NNP
cord-321607-3r736dnk	235	38	disc	disc	VBP
cord-321607-3r736dnk	235	39	large	large	JJ
cord-321607-3r736dnk	235	40	tumor	tumor	NN
cord-321607-3r736dnk	235	41	suppressor	suppressor	NN
cord-321607-3r736dnk	235	42	,	,	,
cord-321607-3r736dnk	235	43	and	and	CC
cord-321607-3r736dnk	235	44	zonula	zonula	NNP
cord-321607-3r736dnk	235	45	occludens-1	occludens-1	NNP
cord-321607-3r736dnk	235	46	)	)	-RRB-
cord-321607-3r736dnk	235	47	that	that	WDT
cord-321607-3r736dnk	235	48	facilitate	facilitate	VBP
cord-321607-3r736dnk	235	49	protein	protein	NN
cord-321607-3r736dnk	235	50	-	-	HYPH
cord-321607-3r736dnk	235	51	protein	protein	NN
cord-321607-3r736dnk	235	52	interactions	interaction	NNS
cord-321607-3r736dnk	235	53	and	and	CC
cord-321607-3r736dnk	235	54	are	be	VBP
cord-321607-3r736dnk	235	55	present	present	JJ
cord-321607-3r736dnk	235	56	in	in	IN
cord-321607-3r736dnk	235	57	many	many	JJ
cord-321607-3r736dnk	235	58	TJ	TJ	NNP
cord-321607-3r736dnk	235	59	/	/	SYM
cord-321607-3r736dnk	235	60	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	235	61	proteins	protein	NNS
cord-321607-3r736dnk	235	62	[	[	-LRB-
cord-321607-3r736dnk	235	63	121	121	CD
cord-321607-3r736dnk	235	64	,	,	,
cord-321607-3r736dnk	235	65	122	122	CD
cord-321607-3r736dnk	235	66	]	]	-RRB-
cord-321607-3r736dnk	235	67	.	.	.
cord-321607-3r736dnk	236	1	The	the	DT
cord-321607-3r736dnk	236	2	interaction	interaction	NN
cord-321607-3r736dnk	236	3	between	between	IN
cord-321607-3r736dnk	236	4	LNX	LNX	NNP
cord-321607-3r736dnk	236	5	and	and	CC
cord-321607-3r736dnk	236	6	RNase	RNase	NNP
cord-321607-3r736dnk	236	7	-	-	HYPH
cord-321607-3r736dnk	236	8	L	L	NNP
cord-321607-3r736dnk	236	9	was	be	VBD
cord-321607-3r736dnk	236	10	confirmed	confirm	VBN
cord-321607-3r736dnk	236	11	in	in	IN
cord-321607-3r736dnk	236	12	293	293	CD
cord-321607-3r736dnk	236	13	T	T	NNP
cord-321607-3r736dnk	236	14	cells	cell	NNS
cord-321607-3r736dnk	236	15	and	and	CC
cord-321607-3r736dnk	236	16	mapped	map	VBN
cord-321607-3r736dnk	236	17	to	to	IN
cord-321607-3r736dnk	236	18	the	the	DT
cord-321607-3r736dnk	236	19	C	c	NN
cord-321607-3r736dnk	236	20	-	-	HYPH
cord-321607-3r736dnk	236	21	terminus	terminus	NN
cord-321607-3r736dnk	236	22	of	of	IN
cord-321607-3r736dnk	236	23	RNase	RNase	NNP
cord-321607-3r736dnk	236	24	-	-	HYPH
cord-321607-3r736dnk	236	25	L	L	NNP
cord-321607-3r736dnk	236	26	and	and	CC
cord-321607-3r736dnk	236	27	the	the	DT
cord-321607-3r736dnk	236	28	PDZ	PDZ	NNP
cord-321607-3r736dnk	236	29	domain	domain	NN
cord-321607-3r736dnk	236	30	-	-	HYPH
cord-321607-3r736dnk	236	31	containing	contain	VBG
cord-321607-3r736dnk	236	32	C	c	NN
cord-321607-3r736dnk	236	33	-	-	HYPH
cord-321607-3r736dnk	236	34	terminus	terminus	NN
cord-321607-3r736dnk	236	35	of	of	IN
cord-321607-3r736dnk	236	36	LNX	LNX	NNP
cord-321607-3r736dnk	237	1	(	(	-LRB-
cord-321607-3r736dnk	237	2	Figure	figure	NN
cord-321607-3r736dnk	237	3	2	2	CD
cord-321607-3r736dnk	237	4	)	)	-RRB-
cord-321607-3r736dnk	237	5	.	.	.
cord-321607-3r736dnk	238	1	LNX	LNX	NNP
cord-321607-3r736dnk	238	2	also	also	RB
cord-321607-3r736dnk	238	3	functions	function	VBZ
cord-321607-3r736dnk	238	4	as	as	IN
cord-321607-3r736dnk	238	5	a	a	DT
cord-321607-3r736dnk	238	6	scaffold	scaffold	NN
cord-321607-3r736dnk	238	7	protein	protein	NN
cord-321607-3r736dnk	238	8	.	.	.
cord-321607-3r736dnk	239	1	In	in	IN
cord-321607-3r736dnk	239	2	addition	addition	NN
cord-321607-3r736dnk	239	3	to	to	IN
cord-321607-3r736dnk	239	4	several	several	JJ
cord-321607-3r736dnk	239	5	characterized	characterize	VBN
cord-321607-3r736dnk	239	6	interactions	interaction	NNS
cord-321607-3r736dnk	239	7	,	,	,
cord-321607-3r736dnk	239	8	a	a	DT
cord-321607-3r736dnk	239	9	proteomic	proteomic	JJ
cord-321607-3r736dnk	239	10	screen	screen	NN
cord-321607-3r736dnk	239	11	for	for	IN
cord-321607-3r736dnk	239	12	potential	potential	JJ
cord-321607-3r736dnk	239	13	LNX	LNX	NNP
cord-321607-3r736dnk	239	14	ubiquitylation	ubiquitylation	NN
cord-321607-3r736dnk	239	15	substrates	substrate	NNS
cord-321607-3r736dnk	239	16	identified	identify	VBD
cord-321607-3r736dnk	239	17	64	64	CD
cord-321607-3r736dnk	239	18	candidate	candidate	NN
cord-321607-3r736dnk	239	19	interactors	interactor	NNS
cord-321607-3r736dnk	239	20	,	,	,
cord-321607-3r736dnk	239	21	and	and	CC
cord-321607-3r736dnk	239	22	yeast	yeast	NN
cord-321607-3r736dnk	239	23	data	datum	NNS
cord-321607-3r736dnk	239	24	suggest	suggest	VBP
cord-321607-3r736dnk	239	25	that	that	IN
cord-321607-3r736dnk	239	26	the	the	DT
cord-321607-3r736dnk	239	27	LNXp80	lnxp80	JJ
cord-321607-3r736dnk	239	28	and	and	CC
cord-321607-3r736dnk	239	29	p70	p70	CD
cord-321607-3r736dnk	239	30	isoforms	isoform	NNS
cord-321607-3r736dnk	239	31	can	can	MD
cord-321607-3r736dnk	239	32	form	form	VB
cord-321607-3r736dnk	239	33	homo	homo	NN
cord-321607-3r736dnk	239	34	-	-	HYPH
cord-321607-3r736dnk	239	35	or	or	CC
cord-321607-3r736dnk	239	36	hetero	hetero	NNS
cord-321607-3r736dnk	239	37	-	-	HYPH
cord-321607-3r736dnk	239	38	oligomers	oligomer	NNS
cord-321607-3r736dnk	239	39	,	,	,
cord-321607-3r736dnk	239	40	potentially	potentially	RB
cord-321607-3r736dnk	239	41	forming	form	VBG
cord-321607-3r736dnk	239	42	large	large	JJ
cord-321607-3r736dnk	239	43	complexes	complex	NNS
cord-321607-3r736dnk	239	44	[	[	-LRB-
cord-321607-3r736dnk	239	45	123	123	CD
cord-321607-3r736dnk	239	46	]	]	-RRB-
cord-321607-3r736dnk	239	47	.	.	.
cord-321607-3r736dnk	240	1	Together	together	RB
cord-321607-3r736dnk	240	2	,	,	,
cord-321607-3r736dnk	240	3	these	these	DT
cord-321607-3r736dnk	240	4	E3	e3	NN
cord-321607-3r736dnk	240	5	ligase	ligase	NN
cord-321607-3r736dnk	240	6	and	and	CC
cord-321607-3r736dnk	240	7	scaffolding	scaffolding	NN
cord-321607-3r736dnk	240	8	functions	function	NNS
cord-321607-3r736dnk	240	9	are	be	VBP
cord-321607-3r736dnk	240	10	thought	think	VBN
cord-321607-3r736dnk	240	11	to	to	TO
cord-321607-3r736dnk	240	12	mediate	mediate	VB
cord-321607-3r736dnk	240	13	the	the	DT
cord-321607-3r736dnk	240	14	physiologic	physiologic	JJ
cord-321607-3r736dnk	240	15	activities	activity	NNS
cord-321607-3r736dnk	240	16	of	of	IN
cord-321607-3r736dnk	240	17	LNX	LNX	NNP
cord-321607-3r736dnk	240	18	,	,	,
cord-321607-3r736dnk	240	19	including	include	VBG
cord-321607-3r736dnk	240	20	cell	cell	NN
cord-321607-3r736dnk	240	21	signaling	signaling	NN
cord-321607-3r736dnk	240	22	,	,	,
cord-321607-3r736dnk	240	23	cell	cell	NN
cord-321607-3r736dnk	240	24	cycle	cycle	NN
cord-321607-3r736dnk	240	25	progression	progression	NN
cord-321607-3r736dnk	240	26	,	,	,
cord-321607-3r736dnk	240	27	tight	tight	JJ
cord-321607-3r736dnk	240	28	junction	junction	NN
cord-321607-3r736dnk	240	29	reorganization	reorganization	NN
cord-321607-3r736dnk	240	30	,	,	,
cord-321607-3r736dnk	240	31	epithelial	epithelial	JJ
cord-321607-3r736dnk	240	32	-	-	HYPH
cord-321607-3r736dnk	240	33	to	to	IN
cord-321607-3r736dnk	240	34	-	-	HYPH
cord-321607-3r736dnk	240	35	mesenchymal	mesenchymal	JJ
cord-321607-3r736dnk	240	36	transition	transition	NN
cord-321607-3r736dnk	240	37	,	,	,
cord-321607-3r736dnk	240	38	and	and	CC
cord-321607-3r736dnk	240	39	its	-PRON-	PRP$
cord-321607-3r736dnk	240	40	association	association	NN
cord-321607-3r736dnk	240	41	with	with	IN
cord-321607-3r736dnk	240	42	glioblastoma	glioblastoma	NNP
cord-321607-3r736dnk	240	43	[	[	-LRB-
cord-321607-3r736dnk	240	44	124	124	CD
cord-321607-3r736dnk	240	45	]	]	-RRB-
cord-321607-3r736dnk	240	46	[	[	-LRB-
cord-321607-3r736dnk	240	47	125	125	CD
cord-321607-3r736dnk	240	48	]	]	-RRB-
cord-321607-3r736dnk	240	49	[	[	-LRB-
cord-321607-3r736dnk	240	50	126	126	CD
cord-321607-3r736dnk	240	51	]	]	-RRB-
cord-321607-3r736dnk	240	52	[	[	-LRB-
cord-321607-3r736dnk	240	53	127	127	CD
cord-321607-3r736dnk	240	54	]	]	-RRB-
cord-321607-3r736dnk	240	55	[	[	-LRB-
cord-321607-3r736dnk	240	56	128	128	CD
cord-321607-3r736dnk	240	57	]	]	-RRB-
cord-321607-3r736dnk	240	58	[	[	-LRB-
cord-321607-3r736dnk	240	59	129	129	CD
cord-321607-3r736dnk	240	60	]	]	-RRB-
cord-321607-3r736dnk	240	61	.	.	.
cord-321607-3r736dnk	241	1	Our	-PRON-	PRP$
cord-321607-3r736dnk	241	2	lab	lab	NN
cord-321607-3r736dnk	241	3	has	have	VBZ
cord-321607-3r736dnk	241	4	also	also	RB
cord-321607-3r736dnk	241	5	identified	identify	VBN
cord-321607-3r736dnk	241	6	a	a	DT
cord-321607-3r736dnk	241	7	third	third	JJ
cord-321607-3r736dnk	241	8	interacting	interact	VBG
cord-321607-3r736dnk	241	9	protein	protein	NN
cord-321607-3r736dnk	241	10	that	that	WDT
cord-321607-3r736dnk	241	11	links	link	VBZ
cord-321607-3r736dnk	241	12	RNase	RNase	NNP
cord-321607-3r736dnk	241	13	-	-	HYPH
cord-321607-3r736dnk	241	14	L	l	NN
cord-321607-3r736dnk	241	15	to	to	IN
cord-321607-3r736dnk	241	16	the	the	DT
cord-321607-3r736dnk	241	17	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	241	18	,	,	,
cord-321607-3r736dnk	241	19	the	the	DT
cord-321607-3r736dnk	241	20	ligand	ligand	NN
cord-321607-3r736dnk	241	21	of	of	IN
cord-321607-3r736dnk	241	22	numb	numb	JJ
cord-321607-3r736dnk	241	23	protein	protein	NN
cord-321607-3r736dnk	241	24	X-1	x-1	NN
cord-321607-3r736dnk	241	25	(	(	-LRB-
cord-321607-3r736dnk	241	26	LNX	LNX	NNP
cord-321607-3r736dnk	241	27	)	)	-RRB-
cord-321607-3r736dnk	241	28	.	.	.
cord-321607-3r736dnk	242	1	LNX	LNX	NNP
cord-321607-3r736dnk	242	2	is	be	VBZ
cord-321607-3r736dnk	242	3	a	a	DT
cord-321607-3r736dnk	242	4	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	242	5	/	/	SYM
cord-321607-3r736dnk	242	6	TJ	TJ	NNP
cord-321607-3r736dnk	242	7	-	-	HYPH
cord-321607-3r736dnk	242	8	associated	associate	VBN
cord-321607-3r736dnk	242	9	protein	protein	NN
cord-321607-3r736dnk	242	10	that	that	WDT
cord-321607-3r736dnk	242	11	was	be	VBD
cord-321607-3r736dnk	242	12	isolated	isolate	VBN
cord-321607-3r736dnk	242	13	through	through	IN
cord-321607-3r736dnk	242	14	a	a	DT
cord-321607-3r736dnk	242	15	yeast	yeast	NN
cord-321607-3r736dnk	242	16	two	two	CD
cord-321607-3r736dnk	242	17	-	-	HYPH
cord-321607-3r736dnk	242	18	hybrid	hybrid	NN
cord-321607-3r736dnk	242	19	screen	screen	NN
cord-321607-3r736dnk	242	20	using	use	VBG
cord-321607-3r736dnk	242	21	RNase	RNase	NNP
cord-321607-3r736dnk	242	22	-	-	HYPH
cord-321607-3r736dnk	242	23	L	L	NNP
cord-321607-3r736dnk	242	24	as	as	IN
cord-321607-3r736dnk	242	25	bait	bait	NN
cord-321607-3r736dnk	242	26	.	.	.
cord-321607-3r736dnk	243	1	LNX	LNX	NNP
cord-321607-3r736dnk	243	2	is	be	VBZ
cord-321607-3r736dnk	243	3	an	an	DT
cord-321607-3r736dnk	243	4	E3	e3	NN
cord-321607-3r736dnk	243	5	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	243	6	ligase	ligase	NN
cord-321607-3r736dnk	243	7	that	that	WDT
cord-321607-3r736dnk	243	8	contains	contain	VBZ
cord-321607-3r736dnk	243	9	a	a	DT
cord-321607-3r736dnk	243	10	RING	ring	NN
cord-321607-3r736dnk	243	11	finger	finger	NN
cord-321607-3r736dnk	243	12	in	in	IN
cord-321607-3r736dnk	243	13	its	-PRON-	PRP$
cord-321607-3r736dnk	243	14	N	n	CD
cord-321607-3r736dnk	243	15	-	-	HYPH
cord-321607-3r736dnk	243	16	terminus	terminus	NN
cord-321607-3r736dnk	243	17	,	,	,
cord-321607-3r736dnk	243	18	which	which	WDT
cord-321607-3r736dnk	243	19	mediates	mediate	VBZ
cord-321607-3r736dnk	243	20	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	243	21	ligase	ligase	NN
cord-321607-3r736dnk	243	22	activity	activity	NN
cord-321607-3r736dnk	243	23	,	,	,
cord-321607-3r736dnk	243	24	and	and	CC
cord-321607-3r736dnk	243	25	four	four	CD
cord-321607-3r736dnk	243	26	PDZ	PDZ	NNP
cord-321607-3r736dnk	243	27	domains	domain	NNS
cord-321607-3r736dnk	243	28	(	(	-LRB-
cord-321607-3r736dnk	243	29	named	name	VBN
cord-321607-3r736dnk	243	30	after	after	IN
cord-321607-3r736dnk	243	31	the	the	DT
cord-321607-3r736dnk	243	32	proteins	protein	NNS
cord-321607-3r736dnk	243	33	postsynaptic	postsynaptic	JJ
cord-321607-3r736dnk	243	34	density	density	NN
cord-321607-3r736dnk	243	35	95	95	CD
cord-321607-3r736dnk	243	36	,	,	,
cord-321607-3r736dnk	243	37	Drosophila	Drosophila	NNP
cord-321607-3r736dnk	243	38	disc	disc	VBP
cord-321607-3r736dnk	243	39	large	large	JJ
cord-321607-3r736dnk	243	40	tumor	tumor	NN
cord-321607-3r736dnk	243	41	suppressor	suppressor	NN
cord-321607-3r736dnk	243	42	,	,	,
cord-321607-3r736dnk	243	43	and	and	CC
cord-321607-3r736dnk	243	44	zonula	zonula	NNP
cord-321607-3r736dnk	243	45	occludens-1	occludens-1	NNP
cord-321607-3r736dnk	243	46	)	)	-RRB-
cord-321607-3r736dnk	243	47	that	that	WDT
cord-321607-3r736dnk	243	48	facilitate	facilitate	VBP
cord-321607-3r736dnk	243	49	protein	protein	NN
cord-321607-3r736dnk	243	50	-	-	HYPH
cord-321607-3r736dnk	243	51	protein	protein	NN
cord-321607-3r736dnk	243	52	interactions	interaction	NNS
cord-321607-3r736dnk	243	53	and	and	CC
cord-321607-3r736dnk	243	54	are	be	VBP
cord-321607-3r736dnk	243	55	present	present	JJ
cord-321607-3r736dnk	243	56	in	in	IN
cord-321607-3r736dnk	243	57	many	many	JJ
cord-321607-3r736dnk	243	58	TJ	TJ	NNP
cord-321607-3r736dnk	243	59	/	/	SYM
cord-321607-3r736dnk	243	60	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	243	61	proteins	protein	NNS
cord-321607-3r736dnk	243	62	[	[	-LRB-
cord-321607-3r736dnk	243	63	121	121	CD
cord-321607-3r736dnk	243	64	,	,	,
cord-321607-3r736dnk	243	65	122	122	CD
cord-321607-3r736dnk	243	66	]	]	-RRB-
cord-321607-3r736dnk	243	67	.	.	.
cord-321607-3r736dnk	244	1	The	the	DT
cord-321607-3r736dnk	244	2	interaction	interaction	NN
cord-321607-3r736dnk	244	3	between	between	IN
cord-321607-3r736dnk	244	4	LNX	LNX	NNP
cord-321607-3r736dnk	244	5	and	and	CC
cord-321607-3r736dnk	244	6	RNase	RNase	NNP
cord-321607-3r736dnk	244	7	-	-	HYPH
cord-321607-3r736dnk	244	8	L	L	NNP
cord-321607-3r736dnk	244	9	was	be	VBD
cord-321607-3r736dnk	244	10	confirmed	confirm	VBN
cord-321607-3r736dnk	244	11	in	in	IN
cord-321607-3r736dnk	244	12	293	293	CD
cord-321607-3r736dnk	244	13	T	T	NNP
cord-321607-3r736dnk	244	14	cells	cell	NNS
cord-321607-3r736dnk	244	15	and	and	CC
cord-321607-3r736dnk	244	16	mapped	map	VBN
cord-321607-3r736dnk	244	17	to	to	IN
cord-321607-3r736dnk	244	18	the	the	DT
cord-321607-3r736dnk	244	19	C	c	NN
cord-321607-3r736dnk	244	20	-	-	HYPH
cord-321607-3r736dnk	244	21	terminus	terminus	NN
cord-321607-3r736dnk	244	22	of	of	IN
cord-321607-3r736dnk	244	23	RNase	RNase	NNP
cord-321607-3r736dnk	244	24	-	-	HYPH
cord-321607-3r736dnk	244	25	L	L	NNP
cord-321607-3r736dnk	244	26	and	and	CC
cord-321607-3r736dnk	244	27	the	the	DT
cord-321607-3r736dnk	244	28	PDZ	PDZ	NNP
cord-321607-3r736dnk	244	29	domain	domain	NN
cord-321607-3r736dnk	244	30	-	-	HYPH
cord-321607-3r736dnk	244	31	containing	contain	VBG
cord-321607-3r736dnk	244	32	C	c	NN
cord-321607-3r736dnk	244	33	-	-	HYPH
cord-321607-3r736dnk	244	34	terminus	terminus	NN
cord-321607-3r736dnk	244	35	of	of	IN
cord-321607-3r736dnk	244	36	LNX	LNX	NNP
cord-321607-3r736dnk	245	1	(	(	-LRB-
cord-321607-3r736dnk	245	2	Figure	figure	NN
cord-321607-3r736dnk	245	3	2	2	CD
cord-321607-3r736dnk	245	4	)	)	-RRB-
cord-321607-3r736dnk	245	5	.	.	.
cord-321607-3r736dnk	246	1	LNX	LNX	NNP
cord-321607-3r736dnk	246	2	also	also	RB
cord-321607-3r736dnk	246	3	functions	function	VBZ
cord-321607-3r736dnk	246	4	as	as	IN
cord-321607-3r736dnk	246	5	a	a	DT
cord-321607-3r736dnk	246	6	scaffold	scaffold	NN
cord-321607-3r736dnk	246	7	protein	protein	NN
cord-321607-3r736dnk	246	8	.	.	.
cord-321607-3r736dnk	247	1	In	in	IN
cord-321607-3r736dnk	247	2	addition	addition	NN
cord-321607-3r736dnk	247	3	to	to	IN
cord-321607-3r736dnk	247	4	several	several	JJ
cord-321607-3r736dnk	247	5	characterized	characterize	VBN
cord-321607-3r736dnk	247	6	interactions	interaction	NNS
cord-321607-3r736dnk	247	7	,	,	,
cord-321607-3r736dnk	247	8	a	a	DT
cord-321607-3r736dnk	247	9	proteomic	proteomic	JJ
cord-321607-3r736dnk	247	10	screen	screen	NN
cord-321607-3r736dnk	247	11	for	for	IN
cord-321607-3r736dnk	247	12	potential	potential	JJ
cord-321607-3r736dnk	247	13	LNX	LNX	NNP
cord-321607-3r736dnk	247	14	ubiquitylation	ubiquitylation	NN
cord-321607-3r736dnk	247	15	substrates	substrate	NNS
cord-321607-3r736dnk	247	16	identified	identify	VBD
cord-321607-3r736dnk	247	17	64	64	CD
cord-321607-3r736dnk	247	18	candidate	candidate	NN
cord-321607-3r736dnk	247	19	interactors	interactor	NNS
cord-321607-3r736dnk	247	20	,	,	,
cord-321607-3r736dnk	247	21	and	and	CC
cord-321607-3r736dnk	247	22	yeast	yeast	NN
cord-321607-3r736dnk	247	23	data	datum	NNS
cord-321607-3r736dnk	247	24	suggest	suggest	VBP
cord-321607-3r736dnk	247	25	that	that	IN
cord-321607-3r736dnk	247	26	the	the	DT
cord-321607-3r736dnk	247	27	LNXp80	lnxp80	JJ
cord-321607-3r736dnk	247	28	and	and	CC
cord-321607-3r736dnk	247	29	p70	p70	CD
cord-321607-3r736dnk	247	30	isoforms	isoform	NNS
cord-321607-3r736dnk	247	31	can	can	MD
cord-321607-3r736dnk	247	32	form	form	VB
cord-321607-3r736dnk	247	33	homo	homo	NN
cord-321607-3r736dnk	247	34	-	-	HYPH
cord-321607-3r736dnk	247	35	or	or	CC
cord-321607-3r736dnk	247	36	hetero	hetero	NNS
cord-321607-3r736dnk	247	37	-	-	HYPH
cord-321607-3r736dnk	247	38	oligomers	oligomer	NNS
cord-321607-3r736dnk	247	39	,	,	,
cord-321607-3r736dnk	247	40	potentially	potentially	RB
cord-321607-3r736dnk	247	41	forming	form	VBG
cord-321607-3r736dnk	247	42	large	large	JJ
cord-321607-3r736dnk	247	43	complexes	complex	NNS
cord-321607-3r736dnk	247	44	[	[	-LRB-
cord-321607-3r736dnk	247	45	123	123	CD
cord-321607-3r736dnk	247	46	]	]	-RRB-
cord-321607-3r736dnk	247	47	.	.	.
cord-321607-3r736dnk	248	1	Together	together	RB
cord-321607-3r736dnk	248	2	,	,	,
cord-321607-3r736dnk	248	3	these	these	DT
cord-321607-3r736dnk	248	4	E3	e3	NN
cord-321607-3r736dnk	248	5	ligase	ligase	NN
cord-321607-3r736dnk	248	6	and	and	CC
cord-321607-3r736dnk	248	7	scaffolding	scaffolding	NN
cord-321607-3r736dnk	248	8	functions	function	NNS
cord-321607-3r736dnk	248	9	are	be	VBP
cord-321607-3r736dnk	248	10	thought	think	VBN
cord-321607-3r736dnk	248	11	to	to	TO
cord-321607-3r736dnk	248	12	mediate	mediate	VB
cord-321607-3r736dnk	248	13	the	the	DT
cord-321607-3r736dnk	248	14	physiologic	physiologic	JJ
cord-321607-3r736dnk	248	15	activities	activity	NNS
cord-321607-3r736dnk	248	16	of	of	IN
cord-321607-3r736dnk	248	17	LNX	LNX	NNP
cord-321607-3r736dnk	248	18	,	,	,
cord-321607-3r736dnk	248	19	including	include	VBG
cord-321607-3r736dnk	248	20	cell	cell	NN
cord-321607-3r736dnk	248	21	signaling	signaling	NN
cord-321607-3r736dnk	248	22	,	,	,
cord-321607-3r736dnk	248	23	cell	cell	NN
cord-321607-3r736dnk	248	24	cycle	cycle	NN
cord-321607-3r736dnk	248	25	progression	progression	NN
cord-321607-3r736dnk	248	26	,	,	,
cord-321607-3r736dnk	248	27	tight	tight	JJ
cord-321607-3r736dnk	248	28	junction	junction	NN
cord-321607-3r736dnk	248	29	reorganization	reorganization	NN
cord-321607-3r736dnk	248	30	,	,	,
cord-321607-3r736dnk	248	31	epithelial	epithelial	JJ
cord-321607-3r736dnk	248	32	-	-	HYPH
cord-321607-3r736dnk	248	33	to	to	IN
cord-321607-3r736dnk	248	34	-	-	HYPH
cord-321607-3r736dnk	248	35	mesenchymal	mesenchymal	JJ
cord-321607-3r736dnk	248	36	transition	transition	NN
cord-321607-3r736dnk	248	37	,	,	,
cord-321607-3r736dnk	248	38	and	and	CC
cord-321607-3r736dnk	248	39	its	-PRON-	PRP$
cord-321607-3r736dnk	248	40	association	association	NN
cord-321607-3r736dnk	248	41	with	with	IN
cord-321607-3r736dnk	248	42	glioblastoma	glioblastoma	NNP
cord-321607-3r736dnk	248	43	[	[	-LRB-
cord-321607-3r736dnk	248	44	124	124	CD
cord-321607-3r736dnk	248	45	]	]	-RRB-
cord-321607-3r736dnk	248	46	[	[	-LRB-
cord-321607-3r736dnk	248	47	125	125	CD
cord-321607-3r736dnk	248	48	]	]	-RRB-
cord-321607-3r736dnk	248	49	[	[	-LRB-
cord-321607-3r736dnk	248	50	126	126	CD
cord-321607-3r736dnk	248	51	]	]	-RRB-
cord-321607-3r736dnk	248	52	[	[	-LRB-
cord-321607-3r736dnk	248	53	127	127	CD
cord-321607-3r736dnk	248	54	]	]	-RRB-
cord-321607-3r736dnk	248	55	[	[	-LRB-
cord-321607-3r736dnk	248	56	128	128	CD
cord-321607-3r736dnk	248	57	]	]	-RRB-
cord-321607-3r736dnk	248	58	[	[	-LRB-
cord-321607-3r736dnk	248	59	129	129	CD
cord-321607-3r736dnk	248	60	]	]	-RRB-
cord-321607-3r736dnk	248	61	.	.	.
cord-321607-3r736dnk	249	1	[	[	-LRB-
cord-321607-3r736dnk	249	2	43	43	CD
cord-321607-3r736dnk	249	3	,	,	,
cord-321607-3r736dnk	249	4	127	127	CD
cord-321607-3r736dnk	249	5	]	]	-RRB-
cord-321607-3r736dnk	249	6	.	.	.
cord-321607-3r736dnk	250	1	RNase	RNase	NNP
cord-321607-3r736dnk	250	2	-	-	HYPH
cord-321607-3r736dnk	250	3	L	l	NN
cord-321607-3r736dnk	250	4	deletions	deletion	NNS
cord-321607-3r736dnk	250	5	were	be	VBD
cord-321607-3r736dnk	250	6	subcloned	subclone	VBN
cord-321607-3r736dnk	250	7	from	from	IN
cord-321607-3r736dnk	250	8	the	the	DT
cord-321607-3r736dnk	250	9	pGEX4T3	pGEX4T3	NNP
cord-321607-3r736dnk	250	10	plasmid	plasmid	NN
cord-321607-3r736dnk	250	11	(	(	-LRB-
cord-321607-3r736dnk	250	12	kindly	kindly	RB
cord-321607-3r736dnk	250	13	provided	provide	VBN
cord-321607-3r736dnk	250	14	by	by	IN
cord-321607-3r736dnk	250	15	R.H.	R.H.	NNP
cord-321607-3r736dnk	250	16	Silverman	Silverman	NNP
cord-321607-3r736dnk	250	17	)	)	-RRB-
cord-321607-3r736dnk	250	18	into	into	IN
cord-321607-3r736dnk	250	19	the	the	DT
cord-321607-3r736dnk	250	20	eukaryotic	eukaryotic	JJ
cord-321607-3r736dnk	250	21	expression	expression	NN
cord-321607-3r736dnk	250	22	plasmid	plasmid	NN
cord-321607-3r736dnk	251	1	pCMV3B	pcmv3b	JJ
cord-321607-3r736dnk	252	1	using	use	VBG
cord-321607-3r736dnk	252	2	the	the	DT
cord-321607-3r736dnk	252	3	BamHI	BamHI	NNP
cord-321607-3r736dnk	252	4	and	and	CC
cord-321607-3r736dnk	252	5	XhoI	XhoI	NNP
cord-321607-3r736dnk	252	6	restriction	restriction	NN
cord-321607-3r736dnk	252	7	sites	site	NNS
cord-321607-3r736dnk	252	8	.	.	.
cord-321607-3r736dnk	253	1	Interaction	interaction	NN
cord-321607-3r736dnk	253	2	with	with	IN
cord-321607-3r736dnk	253	3	LNX	LNX	NNP
cord-321607-3r736dnk	253	4	validated	validate	VBD
cord-321607-3r736dnk	253	5	our	-PRON-	PRP$
cord-321607-3r736dnk	253	6	model	model	NN
cord-321607-3r736dnk	253	7	for	for	IN
cord-321607-3r736dnk	253	8	a	a	DT
cord-321607-3r736dnk	253	9	role	role	NN
cord-321607-3r736dnk	253	10	for	for	IN
cord-321607-3r736dnk	253	11	RNase	RNase	NNP
cord-321607-3r736dnk	253	12	-	-	HYPH
cord-321607-3r736dnk	253	13	L	l	NN
cord-321607-3r736dnk	253	14	in	in	IN
cord-321607-3r736dnk	253	15	the	the	DT
cord-321607-3r736dnk	253	16	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	253	17	.	.	.
cord-321607-3r736dnk	254	1	Although	although	IN
cord-321607-3r736dnk	254	2	a	a	DT
cord-321607-3r736dnk	254	3	logical	logical	JJ
cord-321607-3r736dnk	254	4	function	function	NN
cord-321607-3r736dnk	254	5	for	for	IN
cord-321607-3r736dnk	254	6	this	this	DT
cord-321607-3r736dnk	254	7	relationship	relationship	NN
cord-321607-3r736dnk	254	8	,	,	,
cord-321607-3r736dnk	254	9	LNX	LNX	NNP
cord-321607-3r736dnk	254	10	does	do	VBZ
cord-321607-3r736dnk	254	11	not	not	RB
cord-321607-3r736dnk	254	12	ubiquitylate	ubiquitylate	JJ
cord-321607-3r736dnk	254	13	RNase	RNase	NNP
cord-321607-3r736dnk	254	14	-	-	HYPH
cord-321607-3r736dnk	254	15	L	L	NNP
cord-321607-3r736dnk	254	16	,	,	,
cord-321607-3r736dnk	254	17	a	a	DT
cord-321607-3r736dnk	254	18	known	know	VBN
cord-321607-3r736dnk	254	19	target	target	NN
cord-321607-3r736dnk	254	20	of	of	IN
cord-321607-3r736dnk	254	21	modification	modification	NN
cord-321607-3r736dnk	254	22	,	,	,
cord-321607-3r736dnk	254	23	and	and	CC
cord-321607-3r736dnk	254	24	like	like	IN
cord-321607-3r736dnk	254	25	filamin	filamin	NNP
cord-321607-3r736dnk	254	26	A	A	NNP
cord-321607-3r736dnk	254	27	(	(	-LRB-
cord-321607-3r736dnk	254	28	FLNA	FLNA	NNP
cord-321607-3r736dnk	254	29	)	)	-RRB-
cord-321607-3r736dnk	254	30	,	,	,
cord-321607-3r736dnk	254	31	it	-PRON-	PRP
cord-321607-3r736dnk	254	32	also	also	RB
cord-321607-3r736dnk	254	33	does	do	VBZ
cord-321607-3r736dnk	254	34	not	not	RB
cord-321607-3r736dnk	254	35	alter	alter	VB
cord-321607-3r736dnk	254	36	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	254	37	induction	induction	NN
cord-321607-3r736dnk	254	38	by	by	IN
cord-321607-3r736dnk	254	39	RNase	RNase	NNP
cord-321607-3r736dnk	254	40	-	-	HYPH
cord-321607-3r736dnk	254	41	L	l	NN
cord-321607-3r736dnk	254	42	cleavage	cleavage	NN
cord-321607-3r736dnk	254	43	products	product	NNS
cord-321607-3r736dnk	254	44	in	in	IN
cord-321607-3r736dnk	254	45	response	response	NN
cord-321607-3r736dnk	254	46	to	to	IN
cord-321607-3r736dnk	254	47	activating	activate	VBG
cord-321607-3r736dnk	254	48	conditions	condition	NNS
cord-321607-3r736dnk	254	49	(	(	-LRB-
cord-321607-3r736dnk	254	50	Figure	figure	NN
cord-321607-3r736dnk	254	51	3A	3a	NN
cord-321607-3r736dnk	254	52	,	,	,
cord-321607-3r736dnk	254	53	B	b	NN
cord-321607-3r736dnk	254	54	)	)	-RRB-
cord-321607-3r736dnk	254	55	.	.	.
cord-321607-3r736dnk	255	1	Contrary	contrary	JJ
cord-321607-3r736dnk	255	2	to	to	IN
cord-321607-3r736dnk	255	3	the	the	DT
cord-321607-3r736dnk	255	4	relationship	relationship	NN
cord-321607-3r736dnk	255	5	with	with	IN
cord-321607-3r736dnk	255	6	FLNA	FLNA	NNP
cord-321607-3r736dnk	255	7	,	,	,
cord-321607-3r736dnk	255	8	however	however	RB
cord-321607-3r736dnk	255	9	,	,	,
cord-321607-3r736dnk	255	10	LNX	LNX	NNP
cord-321607-3r736dnk	255	11	interaction	interaction	NN
cord-321607-3r736dnk	255	12	with	with	IN
cord-321607-3r736dnk	255	13	RNase	RNase	NNP
cord-321607-3r736dnk	255	14	-	-	HYPH
cord-321607-3r736dnk	255	15	L	L	NNP
cord-321607-3r736dnk	255	16	is	be	VBZ
cord-321607-3r736dnk	255	17	not	not	RB
cord-321607-3r736dnk	255	18	abrogated	abrogate	VBN
cord-321607-3r736dnk	255	19	under	under	IN
cord-321607-3r736dnk	255	20	activating	activate	VBG
cord-321607-3r736dnk	255	21	conditions	condition	NNS
cord-321607-3r736dnk	255	22	(	(	-LRB-
cord-321607-3r736dnk	255	23	Figure	figure	NN
cord-321607-3r736dnk	255	24	3C	3c	NN
cord-321607-3r736dnk	255	25	)	)	-RRB-
cord-321607-3r736dnk	255	26	.	.	.
cord-321607-3r736dnk	256	1	This	this	DT
cord-321607-3r736dnk	256	2	lack	lack	NN
cord-321607-3r736dnk	256	3	of	of	IN
cord-321607-3r736dnk	256	4	regulation	regulation	NN
cord-321607-3r736dnk	256	5	or	or	CC
cord-321607-3r736dnk	256	6	modification	modification	NN
cord-321607-3r736dnk	256	7	may	may	MD
cord-321607-3r736dnk	256	8	indicate	indicate	VB
cord-321607-3r736dnk	256	9	that	that	IN
cord-321607-3r736dnk	256	10	LNX	LNX	NNP
cord-321607-3r736dnk	256	11	is	be	VBZ
cord-321607-3r736dnk	256	12	functioning	function	VBG
cord-321607-3r736dnk	256	13	as	as	IN
cord-321607-3r736dnk	256	14	a	a	DT
cord-321607-3r736dnk	256	15	.	.	.
cord-321607-3r736dnk	257	1	Cell	cell	NN
cord-321607-3r736dnk	257	2	lysates	lysate	NNS
cord-321607-3r736dnk	257	3	were	be	VBD
cord-321607-3r736dnk	257	4	immunoprecipitated	immunoprecipitate	VBN
cord-321607-3r736dnk	257	5	(	(	-LRB-
cord-321607-3r736dnk	257	6	IP	IP	NNP
cord-321607-3r736dnk	257	7	)	)	-RRB-
cord-321607-3r736dnk	257	8	using	use	VBG
cord-321607-3r736dnk	257	9	anti	anti	JJ
cord-321607-3r736dnk	257	10	-	-	JJ
cord-321607-3r736dnk	257	11	Myc	myc	JJ
cord-321607-3r736dnk	257	12	-	-	HYPH
cord-321607-3r736dnk	257	13	tag	tag	NNP
cord-321607-3r736dnk	257	14	or	or	CC
cord-321607-3r736dnk	257	15	IgG	IgG	NNP
cord-321607-3r736dnk	257	16	control	control	NN
cord-321607-3r736dnk	257	17	antibodies	antibody	NNS
cord-321607-3r736dnk	257	18	bound	bind	VBN
cord-321607-3r736dnk	257	19	to	to	TO
cord-321607-3r736dnk	257	20	protein	protein	VB
cord-321607-3r736dnk	257	21	A	A	NNP
cord-321607-3r736dnk	257	22	/	/	SYM
cord-321607-3r736dnk	257	23	G	g	NN
cord-321607-3r736dnk	257	24	agarose	agarose	NN
cord-321607-3r736dnk	257	25	beads	bead	NNS
cord-321607-3r736dnk	257	26	.	.	.
cord-321607-3r736dnk	258	1	Bound	bound	JJ
cord-321607-3r736dnk	258	2	protein	protein	NN
cord-321607-3r736dnk	258	3	complexes	complex	NNS
cord-321607-3r736dnk	258	4	were	be	VBD
cord-321607-3r736dnk	258	5	detected	detect	VBN
cord-321607-3r736dnk	258	6	by	by	IN
cord-321607-3r736dnk	258	7	Western	western	JJ
cord-321607-3r736dnk	258	8	blot	blot	NN
cord-321607-3r736dnk	258	9	analysis	analysis	NN
cord-321607-3r736dnk	258	10	using	use	VBG
cord-321607-3r736dnk	258	11	the	the	DT
cord-321607-3r736dnk	258	12	antibodies	antibody	NNS
cord-321607-3r736dnk	258	13	as	as	IN
cord-321607-3r736dnk	258	14	indicated	indicate	VBN
cord-321607-3r736dnk	258	15	;	;	:
cord-321607-3r736dnk	258	16	(	(	-LRB-
cord-321607-3r736dnk	258	17	B	b	NN
cord-321607-3r736dnk	258	18	)	)	-RRB-
cord-321607-3r736dnk	258	19	RNase	RNase	NNP
cord-321607-3r736dnk	258	20	-	-	HYPH
cord-321607-3r736dnk	258	21	L	l	NN
cord-321607-3r736dnk	258	22	and	and	CC
cord-321607-3r736dnk	258	23	(	(	-LRB-
cord-321607-3r736dnk	258	24	C	c	NN
cord-321607-3r736dnk	258	25	)	)	-RRB-
cord-321607-3r736dnk	259	1	LNX	LNX	NNP
cord-321607-3r736dnk	259	2	deletions	deletion	NNS
cord-321607-3r736dnk	259	3	were	be	VBD
cord-321607-3r736dnk	259	4	used	use	VBN
cord-321607-3r736dnk	259	5	in	in	IN
cord-321607-3r736dnk	259	6	IP	IP	NNP
cord-321607-3r736dnk	259	7	studies	study	NNS
cord-321607-3r736dnk	259	8	as	as	IN
cord-321607-3r736dnk	259	9	in	in	IN
cord-321607-3r736dnk	259	10	(	(	-LRB-
cord-321607-3r736dnk	259	11	A	a	NN
cord-321607-3r736dnk	259	12	)	)	-RRB-
cord-321607-3r736dnk	259	13	to	to	TO
cord-321607-3r736dnk	259	14	determine	determine	VB
cord-321607-3r736dnk	259	15	their	-PRON-	PRP$
cord-321607-3r736dnk	259	16	respective	respective	JJ
cord-321607-3r736dnk	259	17	interaction	interaction	NN
cord-321607-3r736dnk	259	18	domains	domain	NNS
cord-321607-3r736dnk	259	19	[	[	-LRB-
cord-321607-3r736dnk	259	20	43	43	CD
cord-321607-3r736dnk	259	21	,	,	,
cord-321607-3r736dnk	259	22	127	127	CD
cord-321607-3r736dnk	259	23	]	]	-RRB-
cord-321607-3r736dnk	259	24	.	.	.
cord-321607-3r736dnk	260	1	RNase	RNase	NNP
cord-321607-3r736dnk	260	2	-	-	HYPH
cord-321607-3r736dnk	260	3	L	l	NN
cord-321607-3r736dnk	260	4	deletions	deletion	NNS
cord-321607-3r736dnk	260	5	were	be	VBD
cord-321607-3r736dnk	260	6	subcloned	subclone	VBN
cord-321607-3r736dnk	260	7	from	from	IN
cord-321607-3r736dnk	260	8	the	the	DT
cord-321607-3r736dnk	260	9	pGEX4T3	pGEX4T3	NNP
cord-321607-3r736dnk	260	10	plasmid	plasmid	NN
cord-321607-3r736dnk	260	11	(	(	-LRB-
cord-321607-3r736dnk	260	12	kindly	kindly	RB
cord-321607-3r736dnk	260	13	provided	provide	VBN
cord-321607-3r736dnk	260	14	by	by	IN
cord-321607-3r736dnk	260	15	R.H.	R.H.	NNP
cord-321607-3r736dnk	260	16	Silverman	Silverman	NNP
cord-321607-3r736dnk	260	17	)	)	-RRB-
cord-321607-3r736dnk	260	18	into	into	IN
cord-321607-3r736dnk	260	19	the	the	DT
cord-321607-3r736dnk	260	20	eukaryotic	eukaryotic	JJ
cord-321607-3r736dnk	260	21	expression	expression	NN
cord-321607-3r736dnk	260	22	plasmid	plasmid	NN
cord-321607-3r736dnk	261	1	pCMV3B	pcmv3b	JJ
cord-321607-3r736dnk	262	1	using	use	VBG
cord-321607-3r736dnk	262	2	the	the	DT
cord-321607-3r736dnk	262	3	BamHI	BamHI	NNP
cord-321607-3r736dnk	262	4	and	and	CC
cord-321607-3r736dnk	262	5	XhoI	XhoI	NNP
cord-321607-3r736dnk	262	6	restriction	restriction	NN
cord-321607-3r736dnk	262	7	sites	site	NNS
cord-321607-3r736dnk	262	8	.	.	.
cord-321607-3r736dnk	263	1	Interaction	interaction	NN
cord-321607-3r736dnk	263	2	with	with	IN
cord-321607-3r736dnk	263	3	LNX	LNX	NNP
cord-321607-3r736dnk	263	4	validated	validate	VBD
cord-321607-3r736dnk	263	5	our	-PRON-	PRP$
cord-321607-3r736dnk	263	6	model	model	NN
cord-321607-3r736dnk	263	7	for	for	IN
cord-321607-3r736dnk	263	8	a	a	DT
cord-321607-3r736dnk	263	9	role	role	NN
cord-321607-3r736dnk	263	10	for	for	IN
cord-321607-3r736dnk	263	11	RNase	RNase	NNP
cord-321607-3r736dnk	263	12	-	-	HYPH
cord-321607-3r736dnk	263	13	L	l	NN
cord-321607-3r736dnk	263	14	in	in	IN
cord-321607-3r736dnk	263	15	the	the	DT
cord-321607-3r736dnk	263	16	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	263	17	.	.	.
cord-321607-3r736dnk	264	1	Although	although	IN
cord-321607-3r736dnk	264	2	a	a	DT
cord-321607-3r736dnk	264	3	logical	logical	JJ
cord-321607-3r736dnk	264	4	function	function	NN
cord-321607-3r736dnk	264	5	for	for	IN
cord-321607-3r736dnk	264	6	this	this	DT
cord-321607-3r736dnk	264	7	relationship	relationship	NN
cord-321607-3r736dnk	264	8	,	,	,
cord-321607-3r736dnk	264	9	LNX	LNX	NNP
cord-321607-3r736dnk	264	10	does	do	VBZ
cord-321607-3r736dnk	264	11	not	not	RB
cord-321607-3r736dnk	264	12	ubiquitylate	ubiquitylate	JJ
cord-321607-3r736dnk	264	13	RNase	RNase	NNP
cord-321607-3r736dnk	264	14	-	-	HYPH
cord-321607-3r736dnk	264	15	L	L	NNP
cord-321607-3r736dnk	264	16	,	,	,
cord-321607-3r736dnk	264	17	a	a	DT
cord-321607-3r736dnk	264	18	known	know	VBN
cord-321607-3r736dnk	264	19	target	target	NN
cord-321607-3r736dnk	264	20	of	of	IN
cord-321607-3r736dnk	264	21	modification	modification	NN
cord-321607-3r736dnk	264	22	,	,	,
cord-321607-3r736dnk	264	23	and	and	CC
cord-321607-3r736dnk	264	24	like	like	IN
cord-321607-3r736dnk	264	25	filamin	filamin	NNP
cord-321607-3r736dnk	264	26	A	A	NNP
cord-321607-3r736dnk	264	27	(	(	-LRB-
cord-321607-3r736dnk	264	28	FLNA	FLNA	NNP
cord-321607-3r736dnk	264	29	)	)	-RRB-
cord-321607-3r736dnk	264	30	,	,	,
cord-321607-3r736dnk	264	31	it	-PRON-	PRP
cord-321607-3r736dnk	264	32	also	also	RB
cord-321607-3r736dnk	264	33	does	do	VBZ
cord-321607-3r736dnk	264	34	not	not	RB
cord-321607-3r736dnk	264	35	alter	alter	VB
cord-321607-3r736dnk	264	36	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	264	37	induction	induction	NN
cord-321607-3r736dnk	264	38	by	by	IN
cord-321607-3r736dnk	264	39	RNase	RNase	NNP
cord-321607-3r736dnk	264	40	-	-	HYPH
cord-321607-3r736dnk	264	41	L	l	NN
cord-321607-3r736dnk	264	42	cleavage	cleavage	NN
cord-321607-3r736dnk	264	43	products	product	NNS
cord-321607-3r736dnk	264	44	in	in	IN
cord-321607-3r736dnk	264	45	response	response	NN
cord-321607-3r736dnk	264	46	to	to	IN
cord-321607-3r736dnk	264	47	activating	activate	VBG
cord-321607-3r736dnk	264	48	conditions	condition	NNS
cord-321607-3r736dnk	264	49	(	(	-LRB-
cord-321607-3r736dnk	264	50	Figure	figure	NN
cord-321607-3r736dnk	264	51	3A	3a	NN
cord-321607-3r736dnk	264	52	,	,	,
cord-321607-3r736dnk	264	53	B	b	NN
cord-321607-3r736dnk	264	54	)	)	-RRB-
cord-321607-3r736dnk	264	55	.	.	.
cord-321607-3r736dnk	265	1	Contrary	contrary	JJ
cord-321607-3r736dnk	265	2	to	to	IN
cord-321607-3r736dnk	265	3	the	the	DT
cord-321607-3r736dnk	265	4	relationship	relationship	NN
cord-321607-3r736dnk	265	5	with	with	IN
cord-321607-3r736dnk	265	6	FLNA	FLNA	NNP
cord-321607-3r736dnk	265	7	,	,	,
cord-321607-3r736dnk	265	8	however	however	RB
cord-321607-3r736dnk	265	9	,	,	,
cord-321607-3r736dnk	265	10	LNX	LNX	NNP
cord-321607-3r736dnk	265	11	interaction	interaction	NN
cord-321607-3r736dnk	265	12	with	with	IN
cord-321607-3r736dnk	265	13	RNase	RNase	NNP
cord-321607-3r736dnk	265	14	-	-	HYPH
cord-321607-3r736dnk	265	15	L	L	NNP
cord-321607-3r736dnk	265	16	is	be	VBZ
cord-321607-3r736dnk	265	17	not	not	RB
cord-321607-3r736dnk	265	18	abrogated	abrogate	VBN
cord-321607-3r736dnk	265	19	under	under	IN
cord-321607-3r736dnk	265	20	activating	activate	VBG
cord-321607-3r736dnk	265	21	conditions	condition	NNS
cord-321607-3r736dnk	265	22	(	(	-LRB-
cord-321607-3r736dnk	265	23	Figure	figure	NN
cord-321607-3r736dnk	265	24	3C	3c	NN
cord-321607-3r736dnk	265	25	)	)	-RRB-
cord-321607-3r736dnk	265	26	.	.	.
cord-321607-3r736dnk	266	1	This	this	DT
cord-321607-3r736dnk	266	2	lack	lack	NN
cord-321607-3r736dnk	266	3	of	of	IN
cord-321607-3r736dnk	266	4	regulation	regulation	NN
cord-321607-3r736dnk	266	5	or	or	CC
cord-321607-3r736dnk	266	6	modification	modification	NN
cord-321607-3r736dnk	266	7	may	may	MD
cord-321607-3r736dnk	266	8	indicate	indicate	VB
cord-321607-3r736dnk	266	9	that	that	IN
cord-321607-3r736dnk	266	10	LNX	LNX	NNP
cord-321607-3r736dnk	266	11	is	be	VBZ
cord-321607-3r736dnk	266	12	functioning	function	VBG
cord-321607-3r736dnk	266	13	as	as	IN
cord-321607-3r736dnk	266	14	a	a	DT
cord-321607-3r736dnk	266	15	scaffold	scaffold	NN
cord-321607-3r736dnk	266	16	when	when	WRB
cord-321607-3r736dnk	266	17	binding	bind	VBG
cord-321607-3r736dnk	266	18	to	to	IN
cord-321607-3r736dnk	266	19	RNase	RNase	NNP
cord-321607-3r736dnk	266	20	-	-	HYPH
cord-321607-3r736dnk	266	21	L	l	NN
cord-321607-3r736dnk	266	22	or	or	CC
cord-321607-3r736dnk	266	23	that	that	IN
cord-321607-3r736dnk	266	24	RNase	RNase	NNP
cord-321607-3r736dnk	266	25	-	-	HYPH
cord-321607-3r736dnk	266	26	L	L	NNP
cord-321607-3r736dnk	266	27	is	be	VBZ
cord-321607-3r736dnk	266	28	regulating	regulate	VBG
cord-321607-3r736dnk	266	29	LNX	LNX	NNP
cord-321607-3r736dnk	266	30	activity	activity	NN
cord-321607-3r736dnk	266	31	.	.	.
cord-321607-3r736dnk	267	1	Like	like	IN
cord-321607-3r736dnk	267	2	RNase	RNase	NNP
cord-321607-3r736dnk	267	3	-	-	HYPH
cord-321607-3r736dnk	267	4	L	l	NN
cord-321607-3r736dnk	267	5	and	and	CC
cord-321607-3r736dnk	267	6	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	267	7	,	,	,
cord-321607-3r736dnk	267	8	LNX	LNX	NNP
cord-321607-3r736dnk	267	9	regulates	regulate	VBZ
cord-321607-3r736dnk	267	10	multiple	multiple	JJ
cord-321607-3r736dnk	267	11	tight	tight	JJ
cord-321607-3r736dnk	267	12	junction	junction	NN
cord-321607-3r736dnk	267	13	(	(	-LRB-
cord-321607-3r736dnk	267	14	TJ	TJ	NNP
cord-321607-3r736dnk	267	15	)	)	-RRB-
cord-321607-3r736dnk	267	16	proteins	protein	NNS
cord-321607-3r736dnk	267	17	[	[	-LRB-
cord-321607-3r736dnk	267	18	126	126	CD
cord-321607-3r736dnk	267	19	,	,	,
cord-321607-3r736dnk	267	20	[	[	-LRB-
cord-321607-3r736dnk	267	21	130	130	CD
cord-321607-3r736dnk	267	22	]	]	-RRB-
cord-321607-3r736dnk	267	23	[	[	-LRB-
cord-321607-3r736dnk	267	24	131	131	CD
cord-321607-3r736dnk	267	25	]	]	-RRB-
cord-321607-3r736dnk	268	1	[	[	-LRB-
cord-321607-3r736dnk	268	2	132	132	CD
cord-321607-3r736dnk	268	3	]	]	-RRB-
cord-321607-3r736dnk	268	4	.	.	.
cord-321607-3r736dnk	269	1	Claudin-1	Claudin-1	NNP
cord-321607-3r736dnk	269	2	is	be	VBZ
cord-321607-3r736dnk	269	3	ubiquitylated	ubiquitylate	VBN
cord-321607-3r736dnk	269	4	by	by	IN
cord-321607-3r736dnk	269	5	LNX	LNX	NNP
cord-321607-3r736dnk	269	6	,	,	,
cord-321607-3r736dnk	269	7	leading	lead	VBG
cord-321607-3r736dnk	269	8	to	to	IN
cord-321607-3r736dnk	269	9	its	-PRON-	PRP$
cord-321607-3r736dnk	269	10	lysosomal	lysosomal	JJ
cord-321607-3r736dnk	269	11	degradation	degradation	NN
cord-321607-3r736dnk	269	12	and	and	CC
cord-321607-3r736dnk	269	13	a	a	DT
cord-321607-3r736dnk	269	14	reduction	reduction	NN
cord-321607-3r736dnk	269	15	in	in	IN
cord-321607-3r736dnk	269	16	TJ	TJ	NNP
cord-321607-3r736dnk	269	17	strands	strand	NNS
cord-321607-3r736dnk	269	18	.	.	.
cord-321607-3r736dnk	270	1	It	-PRON-	PRP
cord-321607-3r736dnk	270	2	also	also	RB
cord-321607-3r736dnk	270	3	colocalizes	colocalize	VBZ
cord-321607-3r736dnk	270	4	with	with	IN
cord-321607-3r736dnk	270	5	claudin-2	claudin-2	NNP
cord-321607-3r736dnk	270	6	in	in	IN
cord-321607-3r736dnk	270	7	late	late	JJ
cord-321607-3r736dnk	270	8	endosomes	endosome	NNS
cord-321607-3r736dnk	270	9	and	and	CC
cord-321607-3r736dnk	270	10	lysosomes	lysosome	NNS
cord-321607-3r736dnk	270	11	,	,	,
cord-321607-3r736dnk	270	12	suggesting	suggest	VBG
cord-321607-3r736dnk	270	13	that	that	IN
cord-321607-3r736dnk	270	14	it	-PRON-	PRP
cord-321607-3r736dnk	270	15	may	may	MD
cord-321607-3r736dnk	270	16	mediate	mediate	VB
cord-321607-3r736dnk	270	17	the	the	DT
cord-321607-3r736dnk	270	18	endocytosis	endocytosis	NN
cord-321607-3r736dnk	270	19	of	of	IN
cord-321607-3r736dnk	270	20	claudins	claudin	NNS
cord-321607-3r736dnk	270	21	to	to	IN
cord-321607-3r736dnk	270	22	lysosomes	lysosome	NNS
cord-321607-3r736dnk	270	23	for	for	IN
cord-321607-3r736dnk	270	24	degradation	degradation	NN
cord-321607-3r736dnk	270	25	[	[	-LRB-
cord-321607-3r736dnk	270	26	126	126	CD
cord-321607-3r736dnk	270	27	]	]	-RRB-
cord-321607-3r736dnk	270	28	.	.	.
cord-321607-3r736dnk	271	1	Given	give	VBN
cord-321607-3r736dnk	271	2	our	-PRON-	PRP$
cord-321607-3r736dnk	271	3	previous	previous	JJ
cord-321607-3r736dnk	271	4	findings	finding	NNS
cord-321607-3r736dnk	271	5	that	that	IN
cord-321607-3r736dnk	271	6	RNase	RNase	NNP
cord-321607-3r736dnk	271	7	-	-	HYPH
cord-321607-3r736dnk	271	8	L	L	NNP
cord-321607-3r736dnk	271	9	upregulates	upregulate	VBZ
cord-321607-3r736dnk	271	10	claudin-1	claudin-1	NNP
cord-321607-3r736dnk	271	11	and	and	CC
cord-321607-3r736dnk	271	12	occludin	occludin	NN
cord-321607-3r736dnk	271	13	following	follow	VBG
cord-321607-3r736dnk	271	14	enteropathogenic	enteropathogenic	JJ
cord-321607-3r736dnk	271	15	E.	E.	NNP
cord-321607-3r736dnk	271	16	coli	coli	NNS
cord-321607-3r736dnk	271	17	(	(	-LRB-
cord-321607-3r736dnk	271	18	EPEC	EPEC	NNP
cord-321607-3r736dnk	271	19	)	)	-RRB-
cord-321607-3r736dnk	271	20	infection	infection	NN
cord-321607-3r736dnk	271	21	,	,	,
cord-321607-3r736dnk	271	22	it	-PRON-	PRP
cord-321607-3r736dnk	271	23	is	be	VBZ
cord-321607-3r736dnk	271	24	plausible	plausible	JJ
cord-321607-3r736dnk	271	25	that	that	IN
cord-321607-3r736dnk	271	26	RNase	RNase	NNP
cord-321607-3r736dnk	271	27	-	-	HYPH
cord-321607-3r736dnk	271	28	L	L	NNP
cord-321607-3r736dnk	271	29	may	may	MD
cord-321607-3r736dnk	271	30	normally	normally	RB
cord-321607-3r736dnk	271	31	bind	bind	VB
cord-321607-3r736dnk	271	32	to	to	IN
cord-321607-3r736dnk	271	33	LNX	LNX	NNP
cord-321607-3r736dnk	271	34	and	and	CC
cord-321607-3r736dnk	271	35	prevent	prevent	VB
cord-321607-3r736dnk	271	36	its	-PRON-	PRP$
cord-321607-3r736dnk	271	37	ubiquitylation	ubiquitylation	NN
cord-321607-3r736dnk	271	38	and	and	CC
cord-321607-3r736dnk	271	39	degradation	degradation	NN
cord-321607-3r736dnk	271	40	of	of	IN
cord-321607-3r736dnk	271	41	claudin-1	claudin-1	NNP
cord-321607-3r736dnk	271	42	.	.	.
cord-321607-3r736dnk	272	1	Whether	whether	IN
cord-321607-3r736dnk	272	2	this	this	DT
cord-321607-3r736dnk	272	3	is	be	VBZ
cord-321607-3r736dnk	272	4	sufficient	sufficient	JJ
cord-321607-3r736dnk	272	5	to	to	TO
cord-321607-3r736dnk	272	6	maintain	maintain	VB
cord-321607-3r736dnk	272	7	the	the	DT
cord-321607-3r736dnk	272	8	barrier	barrier	NN
cord-321607-3r736dnk	272	9	function	function	NN
cord-321607-3r736dnk	272	10	observed	observe	VBN
cord-321607-3r736dnk	272	11	in	in	IN
cord-321607-3r736dnk	272	12	RNase	RNase	NNP
cord-321607-3r736dnk	272	13	-	-	HYPH
cord-321607-3r736dnk	272	14	L	l	NN
cord-321607-3r736dnk	272	15	-	-	HYPH
cord-321607-3r736dnk	272	16	expressing	express	VBG
cord-321607-3r736dnk	272	17	cells	cell	NNS
cord-321607-3r736dnk	272	18	compared	compare	VBN
cord-321607-3r736dnk	272	19	to	to	IN
cord-321607-3r736dnk	272	20	deficient	deficient	JJ
cord-321607-3r736dnk	272	21	cells	cell	NNS
cord-321607-3r736dnk	272	22	,	,	,
cord-321607-3r736dnk	272	23	or	or	CC
cord-321607-3r736dnk	272	24	if	if	IN
cord-321607-3r736dnk	272	25	other	other	JJ
cord-321607-3r736dnk	272	26	factors	factor	NNS
cord-321607-3r736dnk	272	27	including	include	VBG
cord-321607-3r736dnk	272	28	FLNA	FLNA	NNP
cord-321607-3r736dnk	272	29	and	and	CC
cord-321607-3r736dnk	272	30	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	272	31	also	also	RB
cord-321607-3r736dnk	272	32	contribute	contribute	VBP
cord-321607-3r736dnk	272	33	,	,	,
cord-321607-3r736dnk	272	34	has	have	VBZ
cord-321607-3r736dnk	272	35	yet	yet	RB
cord-321607-3r736dnk	272	36	to	to	TO
cord-321607-3r736dnk	272	37	be	be	VB
cord-321607-3r736dnk	272	38	determined	determine	VBN
cord-321607-3r736dnk	272	39	.	.	.
cord-321607-3r736dnk	273	1	In	in	IN
cord-321607-3r736dnk	273	2	support	support	NN
cord-321607-3r736dnk	273	3	of	of	IN
cord-321607-3r736dnk	273	4	a	a	DT
cord-321607-3r736dnk	273	5	cooperative	cooperative	JJ
cord-321607-3r736dnk	273	6	complex	complex	NN
cord-321607-3r736dnk	273	7	however	however	RB
cord-321607-3r736dnk	273	8	,	,	,
cord-321607-3r736dnk	273	9	is	be	VBZ
cord-321607-3r736dnk	273	10	data	datum	NNS
cord-321607-3r736dnk	273	11	indicating	indicate	VBG
cord-321607-3r736dnk	273	12	that	that	IN
cord-321607-3r736dnk	273	13	FLNA	FLNA	NNP
cord-321607-3r736dnk	273	14	and	and	CC
cord-321607-3r736dnk	273	15	LNX	LNX	NNP
cord-321607-3r736dnk	273	16	are	be	VBP
cord-321607-3r736dnk	273	17	capable	capable	JJ
cord-321607-3r736dnk	273	18	of	of	IN
cord-321607-3r736dnk	273	19	interacting	interact	VBG
cord-321607-3r736dnk	273	20	with	with	IN
cord-321607-3r736dnk	273	21	each	each	DT
cord-321607-3r736dnk	273	22	other	other	JJ
cord-321607-3r736dnk	273	23	in	in	IN
cord-321607-3r736dnk	273	24	a	a	DT
cord-321607-3r736dnk	273	25	manner	manner	NN
cord-321607-3r736dnk	273	26	that	that	WDT
cord-321607-3r736dnk	273	27	is	be	VBZ
cord-321607-3r736dnk	273	28	not	not	RB
cord-321607-3r736dnk	273	29	altered	alter	VBN
cord-321607-3r736dnk	273	30	by	by	IN
cord-321607-3r736dnk	273	31	RNase	RNase	NNP
cord-321607-3r736dnk	273	32	-	-	HYPH
cord-321607-3r736dnk	273	33	L	l	NN
cord-321607-3r736dnk	273	34	overexpression	overexpression	NN
cord-321607-3r736dnk	273	35	(	(	-LRB-
cord-321607-3r736dnk	273	36	Figure	Figure	NNP
cord-321607-3r736dnk	273	37	3D	3d	NN
cord-321607-3r736dnk	273	38	)	)	-RRB-
cord-321607-3r736dnk	273	39	.	.	.
cord-321607-3r736dnk	274	1	Given	give	VBN
cord-321607-3r736dnk	274	2	that	that	IN
cord-321607-3r736dnk	274	3	FLNA	FLNA	NNP
cord-321607-3r736dnk	274	4	binds	bind	VBZ
cord-321607-3r736dnk	274	5	to	to	IN
cord-321607-3r736dnk	274	6	the	the	DT
cord-321607-3r736dnk	274	7	N	n	NN
cord-321607-3r736dnk	274	8	-	-	HYPH
cord-321607-3r736dnk	274	9	terminus	terminus	NN
cord-321607-3r736dnk	274	10	of	of	IN
cord-321607-3r736dnk	274	11	RNase	RNase	NNP
cord-321607-3r736dnk	274	12	-	-	HYPH
cord-321607-3r736dnk	274	13	L	L	NNP
cord-321607-3r736dnk	274	14	and	and	CC
cord-321607-3r736dnk	274	15	LNX	LNX	NNP
cord-321607-3r736dnk	274	16	binds	bind	VBZ
cord-321607-3r736dnk	274	17	to	to	IN
cord-321607-3r736dnk	274	18	the	the	DT
cord-321607-3r736dnk	274	19	C	C	NNP
cord-321607-3r736dnk	274	20	-	-	HYPH
cord-321607-3r736dnk	274	21	terminus	terminus	NN
cord-321607-3r736dnk	274	22	(	(	-LRB-
cord-321607-3r736dnk	274	23	Figure	figure	NN
cord-321607-3r736dnk	274	24	2B	2b	CD
cord-321607-3r736dnk	274	25	)	)	-RRB-
cord-321607-3r736dnk	274	26	,	,	,
cord-321607-3r736dnk	274	27	it	-PRON-	PRP
cord-321607-3r736dnk	274	28	is	be	VBZ
cord-321607-3r736dnk	274	29	plausible	plausible	JJ
cord-321607-3r736dnk	274	30	that	that	IN
cord-321607-3r736dnk	274	31	RNase	RNase	NNP
cord-321607-3r736dnk	274	32	-	-	HYPH
cord-321607-3r736dnk	274	33	L	L	NNP
cord-321607-3r736dnk	274	34	could	could	MD
cord-321607-3r736dnk	274	35	bind	bind	VB
cord-321607-3r736dnk	274	36	to	to	IN
cord-321607-3r736dnk	274	37	both	both	DT
cord-321607-3r736dnk	274	38	proteins	protein	NNS
cord-321607-3r736dnk	274	39	simultaneously	simultaneously	RB
cord-321607-3r736dnk	274	40	in	in	IN
cord-321607-3r736dnk	274	41	a	a	DT
cord-321607-3r736dnk	274	42	complex	complex	NN
cord-321607-3r736dnk	274	43	at	at	IN
cord-321607-3r736dnk	274	44	the	the	DT
cord-321607-3r736dnk	274	45	interface	interface	NN
cord-321607-3r736dnk	274	46	of	of	IN
cord-321607-3r736dnk	274	47	TJs	TJs	NNP
cord-321607-3r736dnk	274	48	and	and	CC
cord-321607-3r736dnk	274	49	the	the	DT
cord-321607-3r736dnk	274	50	actin	actin	NN
cord-321607-3r736dnk	274	51	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	274	52	.	.	.
cord-321607-3r736dnk	275	1	scaffold	scaffold	NN
cord-321607-3r736dnk	275	2	when	when	WRB
cord-321607-3r736dnk	275	3	binding	bind	VBG
cord-321607-3r736dnk	275	4	to	to	IN
cord-321607-3r736dnk	275	5	RNase	RNase	NNP
cord-321607-3r736dnk	275	6	-	-	HYPH
cord-321607-3r736dnk	275	7	L	l	NN
cord-321607-3r736dnk	275	8	or	or	CC
cord-321607-3r736dnk	275	9	that	that	IN
cord-321607-3r736dnk	275	10	RNase	RNase	NNP
cord-321607-3r736dnk	275	11	-	-	HYPH
cord-321607-3r736dnk	275	12	L	L	NNP
cord-321607-3r736dnk	275	13	is	be	VBZ
cord-321607-3r736dnk	275	14	regulating	regulate	VBG
cord-321607-3r736dnk	275	15	LNX	LNX	NNP
cord-321607-3r736dnk	275	16	activity	activity	NN
cord-321607-3r736dnk	275	17	.	.	.
cord-321607-3r736dnk	276	1	Like	like	IN
cord-321607-3r736dnk	276	2	RNase	RNase	NNP
cord-321607-3r736dnk	276	3	-	-	HYPH
cord-321607-3r736dnk	276	4	L	l	NN
cord-321607-3r736dnk	276	5	and	and	CC
cord-321607-3r736dnk	276	6	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	276	7	,	,	,
cord-321607-3r736dnk	276	8	LNX	LNX	NNP
cord-321607-3r736dnk	276	9	regulates	regulate	VBZ
cord-321607-3r736dnk	276	10	multiple	multiple	JJ
cord-321607-3r736dnk	276	11	tight	tight	JJ
cord-321607-3r736dnk	276	12	junction	junction	NN
cord-321607-3r736dnk	276	13	(	(	-LRB-
cord-321607-3r736dnk	276	14	TJ	TJ	NNP
cord-321607-3r736dnk	276	15	)	)	-RRB-
cord-321607-3r736dnk	276	16	proteins	protein	NNS
cord-321607-3r736dnk	276	17	[	[	-LRB-
cord-321607-3r736dnk	276	18	126	126	CD
cord-321607-3r736dnk	276	19	,	,	,
cord-321607-3r736dnk	276	20	[	[	-LRB-
cord-321607-3r736dnk	276	21	130	130	CD
cord-321607-3r736dnk	276	22	]	]	-RRB-
cord-321607-3r736dnk	276	23	[	[	-LRB-
cord-321607-3r736dnk	276	24	131	131	CD
cord-321607-3r736dnk	276	25	]	]	-RRB-
cord-321607-3r736dnk	277	1	[	[	-LRB-
cord-321607-3r736dnk	277	2	132	132	CD
cord-321607-3r736dnk	277	3	]	]	-RRB-
cord-321607-3r736dnk	277	4	.	.	.
cord-321607-3r736dnk	278	1	Claudin-1	Claudin-1	NNP
cord-321607-3r736dnk	278	2	is	be	VBZ
cord-321607-3r736dnk	278	3	ubiquitylated	ubiquitylate	VBN
cord-321607-3r736dnk	278	4	by	by	IN
cord-321607-3r736dnk	278	5	LNX	LNX	NNP
cord-321607-3r736dnk	278	6	,	,	,
cord-321607-3r736dnk	278	7	leading	lead	VBG
cord-321607-3r736dnk	278	8	to	to	IN
cord-321607-3r736dnk	278	9	its	-PRON-	PRP$
cord-321607-3r736dnk	278	10	lysosomal	lysosomal	JJ
cord-321607-3r736dnk	278	11	degradation	degradation	NN
cord-321607-3r736dnk	278	12	and	and	CC
cord-321607-3r736dnk	278	13	a	a	DT
cord-321607-3r736dnk	278	14	reduction	reduction	NN
cord-321607-3r736dnk	278	15	in	in	IN
cord-321607-3r736dnk	278	16	TJ	TJ	NNP
cord-321607-3r736dnk	278	17	strands	strand	NNS
cord-321607-3r736dnk	278	18	.	.	.
cord-321607-3r736dnk	279	1	It	-PRON-	PRP
cord-321607-3r736dnk	279	2	also	also	RB
cord-321607-3r736dnk	279	3	colocalizes	colocalize	VBZ
cord-321607-3r736dnk	279	4	with	with	IN
cord-321607-3r736dnk	279	5	claudin-2	claudin-2	NNP
cord-321607-3r736dnk	279	6	in	in	IN
cord-321607-3r736dnk	279	7	late	late	JJ
cord-321607-3r736dnk	279	8	endosomes	endosome	NNS
cord-321607-3r736dnk	279	9	and	and	CC
cord-321607-3r736dnk	279	10	lysosomes	lysosome	NNS
cord-321607-3r736dnk	279	11	,	,	,
cord-321607-3r736dnk	279	12	suggesting	suggest	VBG
cord-321607-3r736dnk	279	13	that	that	IN
cord-321607-3r736dnk	279	14	it	-PRON-	PRP
cord-321607-3r736dnk	279	15	may	may	MD
cord-321607-3r736dnk	279	16	mediate	mediate	VB
cord-321607-3r736dnk	279	17	the	the	DT
cord-321607-3r736dnk	279	18	endocytosis	endocytosis	NN
cord-321607-3r736dnk	279	19	of	of	IN
cord-321607-3r736dnk	279	20	claudins	claudin	NNS
cord-321607-3r736dnk	279	21	to	to	IN
cord-321607-3r736dnk	279	22	lysosomes	lysosome	NNS
cord-321607-3r736dnk	279	23	for	for	IN
cord-321607-3r736dnk	279	24	degradation	degradation	NN
cord-321607-3r736dnk	279	25	[	[	-LRB-
cord-321607-3r736dnk	279	26	126	126	CD
cord-321607-3r736dnk	279	27	]	]	-RRB-
cord-321607-3r736dnk	279	28	.	.	.
cord-321607-3r736dnk	280	1	Given	give	VBN
cord-321607-3r736dnk	280	2	our	-PRON-	PRP$
cord-321607-3r736dnk	280	3	previous	previous	JJ
cord-321607-3r736dnk	280	4	findings	finding	NNS
cord-321607-3r736dnk	280	5	that	that	IN
cord-321607-3r736dnk	280	6	RNase	RNase	NNP
cord-321607-3r736dnk	280	7	-	-	HYPH
cord-321607-3r736dnk	280	8	L	L	NNP
cord-321607-3r736dnk	280	9	upregulates	upregulate	VBZ
cord-321607-3r736dnk	280	10	claudin-1	claudin-1	NNP
cord-321607-3r736dnk	280	11	and	and	CC
cord-321607-3r736dnk	280	12	occludin	occludin	NN
cord-321607-3r736dnk	280	13	following	follow	VBG
cord-321607-3r736dnk	280	14	enteropathogenic	enteropathogenic	JJ
cord-321607-3r736dnk	280	15	E.	E.	NNP
cord-321607-3r736dnk	280	16	coli	coli	NNS
cord-321607-3r736dnk	280	17	(	(	-LRB-
cord-321607-3r736dnk	280	18	EPEC	EPEC	NNP
cord-321607-3r736dnk	280	19	)	)	-RRB-
cord-321607-3r736dnk	280	20	infection	infection	NN
cord-321607-3r736dnk	280	21	,	,	,
cord-321607-3r736dnk	280	22	it	-PRON-	PRP
cord-321607-3r736dnk	280	23	is	be	VBZ
cord-321607-3r736dnk	280	24	plausible	plausible	JJ
cord-321607-3r736dnk	280	25	that	that	IN
cord-321607-3r736dnk	280	26	RNase	RNase	NNP
cord-321607-3r736dnk	280	27	-	-	HYPH
cord-321607-3r736dnk	280	28	L	L	NNP
cord-321607-3r736dnk	280	29	may	may	MD
cord-321607-3r736dnk	280	30	normally	normally	RB
cord-321607-3r736dnk	280	31	bind	bind	VB
cord-321607-3r736dnk	280	32	to	to	IN
cord-321607-3r736dnk	280	33	LNX	LNX	NNP
cord-321607-3r736dnk	280	34	and	and	CC
cord-321607-3r736dnk	280	35	prevent	prevent	VB
cord-321607-3r736dnk	280	36	its	-PRON-	PRP$
cord-321607-3r736dnk	280	37	ubiquitylation	ubiquitylation	NN
cord-321607-3r736dnk	280	38	and	and	CC
cord-321607-3r736dnk	280	39	degradation	degradation	NN
cord-321607-3r736dnk	280	40	of	of	IN
cord-321607-3r736dnk	280	41	claudin-1	claudin-1	NNP
cord-321607-3r736dnk	280	42	.	.	.
cord-321607-3r736dnk	281	1	Whether	whether	IN
cord-321607-3r736dnk	281	2	this	this	DT
cord-321607-3r736dnk	281	3	is	be	VBZ
cord-321607-3r736dnk	281	4	sufficient	sufficient	JJ
cord-321607-3r736dnk	281	5	to	to	TO
cord-321607-3r736dnk	281	6	maintain	maintain	VB
cord-321607-3r736dnk	281	7	the	the	DT
cord-321607-3r736dnk	281	8	barrier	barrier	NN
cord-321607-3r736dnk	281	9	function	function	NN
cord-321607-3r736dnk	281	10	observed	observe	VBN
cord-321607-3r736dnk	281	11	in	in	IN
cord-321607-3r736dnk	281	12	RNase	RNase	NNP
cord-321607-3r736dnk	281	13	-	-	HYPH
cord-321607-3r736dnk	281	14	L	l	NN
cord-321607-3r736dnk	281	15	-	-	HYPH
cord-321607-3r736dnk	281	16	expressing	express	VBG
cord-321607-3r736dnk	281	17	cells	cell	NNS
cord-321607-3r736dnk	281	18	compared	compare	VBN
cord-321607-3r736dnk	281	19	to	to	IN
cord-321607-3r736dnk	281	20	deficient	deficient	JJ
cord-321607-3r736dnk	281	21	cells	cell	NNS
cord-321607-3r736dnk	281	22	,	,	,
cord-321607-3r736dnk	281	23	or	or	CC
cord-321607-3r736dnk	281	24	if	if	IN
cord-321607-3r736dnk	281	25	other	other	JJ
cord-321607-3r736dnk	281	26	factors	factor	NNS
cord-321607-3r736dnk	281	27	including	include	VBG
cord-321607-3r736dnk	281	28	FLNA	FLNA	NNP
cord-321607-3r736dnk	281	29	and	and	CC
cord-321607-3r736dnk	281	30	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	281	31	also	also	RB
cord-321607-3r736dnk	281	32	contribute	contribute	VBP
cord-321607-3r736dnk	281	33	,	,	,
cord-321607-3r736dnk	281	34	has	have	VBZ
cord-321607-3r736dnk	281	35	yet	yet	RB
cord-321607-3r736dnk	281	36	to	to	TO
cord-321607-3r736dnk	281	37	be	be	VB
cord-321607-3r736dnk	281	38	determined	determine	VBN
cord-321607-3r736dnk	281	39	.	.	.
cord-321607-3r736dnk	282	1	In	in	IN
cord-321607-3r736dnk	282	2	support	support	NN
cord-321607-3r736dnk	282	3	of	of	IN
cord-321607-3r736dnk	282	4	a	a	DT
cord-321607-3r736dnk	282	5	cooperative	cooperative	JJ
cord-321607-3r736dnk	282	6	complex	complex	NN
cord-321607-3r736dnk	282	7	however	however	RB
cord-321607-3r736dnk	282	8	,	,	,
cord-321607-3r736dnk	282	9	is	be	VBZ
cord-321607-3r736dnk	282	10	data	datum	NNS
cord-321607-3r736dnk	282	11	indicating	indicate	VBG
cord-321607-3r736dnk	282	12	that	that	IN
cord-321607-3r736dnk	282	13	FLNA	FLNA	NNP
cord-321607-3r736dnk	282	14	and	and	CC
cord-321607-3r736dnk	282	15	LNX	LNX	NNP
cord-321607-3r736dnk	282	16	are	be	VBP
cord-321607-3r736dnk	282	17	capable	capable	JJ
cord-321607-3r736dnk	282	18	of	of	IN
cord-321607-3r736dnk	282	19	interacting	interact	VBG
cord-321607-3r736dnk	282	20	with	with	IN
cord-321607-3r736dnk	282	21	each	each	DT
cord-321607-3r736dnk	282	22	other	other	JJ
cord-321607-3r736dnk	282	23	in	in	IN
cord-321607-3r736dnk	282	24	a	a	DT
cord-321607-3r736dnk	282	25	manner	manner	NN
cord-321607-3r736dnk	282	26	that	that	WDT
cord-321607-3r736dnk	282	27	is	be	VBZ
cord-321607-3r736dnk	282	28	not	not	RB
cord-321607-3r736dnk	282	29	altered	alter	VBN
cord-321607-3r736dnk	282	30	by	by	IN
cord-321607-3r736dnk	282	31	RNase	RNase	NNP
cord-321607-3r736dnk	282	32	-	-	HYPH
cord-321607-3r736dnk	282	33	L	l	NN
cord-321607-3r736dnk	282	34	overexpression	overexpression	NN
cord-321607-3r736dnk	282	35	(	(	-LRB-
cord-321607-3r736dnk	282	36	Figure	Figure	NNP
cord-321607-3r736dnk	282	37	3D	3d	NN
cord-321607-3r736dnk	282	38	)	)	-RRB-
cord-321607-3r736dnk	282	39	.	.	.
cord-321607-3r736dnk	283	1	Given	give	VBN
cord-321607-3r736dnk	283	2	that	that	IN
cord-321607-3r736dnk	283	3	FLNA	FLNA	NNP
cord-321607-3r736dnk	283	4	binds	bind	VBZ
cord-321607-3r736dnk	283	5	to	to	IN
cord-321607-3r736dnk	283	6	the	the	DT
cord-321607-3r736dnk	283	7	N	n	NN
cord-321607-3r736dnk	283	8	-	-	HYPH
cord-321607-3r736dnk	283	9	terminus	terminus	NN
cord-321607-3r736dnk	283	10	of	of	IN
cord-321607-3r736dnk	283	11	RNase	RNase	NNP
cord-321607-3r736dnk	283	12	-	-	HYPH
cord-321607-3r736dnk	283	13	L	L	NNP
cord-321607-3r736dnk	283	14	and	and	CC
cord-321607-3r736dnk	283	15	LNX	LNX	NNP
cord-321607-3r736dnk	283	16	binds	bind	VBZ
cord-321607-3r736dnk	283	17	to	to	IN
cord-321607-3r736dnk	283	18	the	the	DT
cord-321607-3r736dnk	283	19	C	C	NNP
cord-321607-3r736dnk	283	20	-	-	HYPH
cord-321607-3r736dnk	283	21	terminus	terminus	NN
cord-321607-3r736dnk	283	22	(	(	-LRB-
cord-321607-3r736dnk	283	23	Figure	figure	NN
cord-321607-3r736dnk	283	24	2B	2b	CD
cord-321607-3r736dnk	283	25	)	)	-RRB-
cord-321607-3r736dnk	283	26	,	,	,
cord-321607-3r736dnk	283	27	it	-PRON-	PRP
cord-321607-3r736dnk	283	28	is	be	VBZ
cord-321607-3r736dnk	283	29	plausible	plausible	JJ
cord-321607-3r736dnk	283	30	that	that	IN
cord-321607-3r736dnk	283	31	RNase	RNase	NNP
cord-321607-3r736dnk	283	32	-	-	HYPH
cord-321607-3r736dnk	283	33	L	L	NNP
cord-321607-3r736dnk	283	34	could	could	MD
cord-321607-3r736dnk	283	35	bind	bind	VB
cord-321607-3r736dnk	283	36	to	to	IN
cord-321607-3r736dnk	283	37	both	both	DT
cord-321607-3r736dnk	283	38	proteins	protein	NNS
cord-321607-3r736dnk	283	39	simultaneously	simultaneously	RB
cord-321607-3r736dnk	283	40	in	in	IN
cord-321607-3r736dnk	283	41	a	a	DT
cord-321607-3r736dnk	283	42	complex	complex	NN
cord-321607-3r736dnk	283	43	at	at	IN
cord-321607-3r736dnk	283	44	the	the	DT
cord-321607-3r736dnk	283	45	interface	interface	NN
cord-321607-3r736dnk	283	46	of	of	IN
cord-321607-3r736dnk	283	47	TJs	TJs	NNP
cord-321607-3r736dnk	283	48	and	and	CC
cord-321607-3r736dnk	283	49	the	the	DT
cord-321607-3r736dnk	283	50	actin	actin	NN
cord-321607-3r736dnk	283	51	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	283	52	.	.	.
cord-321607-3r736dnk	284	1	Collectively	collectively	RB
cord-321607-3r736dnk	284	2	,	,	,
cord-321607-3r736dnk	284	3	the	the	DT
cord-321607-3r736dnk	284	4	data	data	NN
cord-321607-3r736dnk	284	5	suggests	suggest	VBZ
cord-321607-3r736dnk	284	6	a	a	DT
cord-321607-3r736dnk	284	7	model	model	NN
cord-321607-3r736dnk	284	8	in	in	IN
cord-321607-3r736dnk	284	9	which	which	WDT
cord-321607-3r736dnk	284	10	FLNA	FLNA	NNP
cord-321607-3r736dnk	284	11	,	,	,
cord-321607-3r736dnk	284	12	LNX	LNX	NNP
cord-321607-3r736dnk	284	13	,	,	,
cord-321607-3r736dnk	284	14	and	and	CC
cord-321607-3r736dnk	284	15	RNase	RNase	NNP
cord-321607-3r736dnk	284	16	-	-	HYPH
cord-321607-3r736dnk	284	17	L	l	NN
cord-321607-3r736dnk	284	18	form	form	VB
cord-321607-3r736dnk	284	19	a	a	DT
cord-321607-3r736dnk	284	20	complex	complex	NN
cord-321607-3r736dnk	284	21	associated	associate	VBN
cord-321607-3r736dnk	284	22	with	with	IN
cord-321607-3r736dnk	284	23	the	the	DT
cord-321607-3r736dnk	284	24	actin	actin	NN
cord-321607-3r736dnk	284	25	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	284	26	.	.	.
cord-321607-3r736dnk	285	1	During	during	IN
cord-321607-3r736dnk	285	2	resting	rest	VBG
cord-321607-3r736dnk	285	3	conditions	condition	NNS
cord-321607-3r736dnk	285	4	,	,	,
cord-321607-3r736dnk	285	5	this	this	DT
cord-321607-3r736dnk	285	6	complex	complex	NN
cord-321607-3r736dnk	285	7	supports	support	VBZ
cord-321607-3r736dnk	285	8	membrane	membrane	NN
cord-321607-3r736dnk	285	9	integrity	integrity	NN
cord-321607-3r736dnk	285	10	to	to	TO
cord-321607-3r736dnk	285	11	inhibit	inhibit	VB
cord-321607-3r736dnk	285	12	endocytosis	endocytosis	NN
cord-321607-3r736dnk	285	13	or	or	CC
cord-321607-3r736dnk	285	14	viral	viral	JJ
cord-321607-3r736dnk	285	15	entry	entry	NN
cord-321607-3r736dnk	285	16	into	into	IN
cord-321607-3r736dnk	285	17	the	the	DT
cord-321607-3r736dnk	285	18	cell	cell	NN
cord-321607-3r736dnk	285	19	.	.	.
cord-321607-3r736dnk	286	1	If	if	IN
cord-321607-3r736dnk	286	2	the	the	DT
cord-321607-3r736dnk	286	3	virus	virus	NN
cord-321607-3r736dnk	286	4	breaches	breach	VBZ
cord-321607-3r736dnk	286	5	the	the	DT
cord-321607-3r736dnk	286	6	membrane	membrane	NN
cord-321607-3r736dnk	286	7	barrier	barrier	NN
cord-321607-3r736dnk	286	8	and	and	CC
cord-321607-3r736dnk	286	9	activates	activate	VBZ
cord-321607-3r736dnk	286	10	OAS	OAS	NNP
cord-321607-3r736dnk	286	11	to	to	TO
cord-321607-3r736dnk	286	12	produce	produce	VB
cord-321607-3r736dnk	286	13	2	2	CD
cord-321607-3r736dnk	286	14	-	-	HYPH
cord-321607-3r736dnk	286	15	5A	5a	NN
cord-321607-3r736dnk	286	16	,	,	,
cord-321607-3r736dnk	286	17	then	then	RB
cord-321607-3r736dnk	286	18	the	the	DT
cord-321607-3r736dnk	286	19	RNase	RNase	NNP
cord-321607-3r736dnk	286	20	-	-	HYPH
cord-321607-3r736dnk	286	21	L	L	NNP
cord-321607-3r736dnk	286	22	-	-	HYPH
cord-321607-3r736dnk	286	23	FLNA	FLNA	NNP
cord-321607-3r736dnk	286	24	interaction	interaction	NN
cord-321607-3r736dnk	286	25	is	be	VBZ
cord-321607-3r736dnk	286	26	abolished	abolish	VBN
cord-321607-3r736dnk	286	27	and	and	CC
cord-321607-3r736dnk	286	28	RNase	RNase	NNP
cord-321607-3r736dnk	286	29	-	-	HYPH
cord-321607-3r736dnk	286	30	L	L	NNP
cord-321607-3r736dnk	286	31	is	be	VBZ
cord-321607-3r736dnk	286	32	released	release	VBN
cord-321607-3r736dnk	286	33	from	from	IN
cord-321607-3r736dnk	286	34	the	the	DT
cord-321607-3r736dnk	286	35	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	286	36	(	(	-LRB-
cord-321607-3r736dnk	286	37	[	[	-LRB-
cord-321607-3r736dnk	286	38	23	23	CD
cord-321607-3r736dnk	286	39	]	]	-RRB-
cord-321607-3r736dnk	286	40	and	and	CC
cord-321607-3r736dnk	286	41	Figure	Figure	NNP
cord-321607-3r736dnk	286	42	4	4	CD
cord-321607-3r736dnk	286	43	)	)	-RRB-
cord-321607-3r736dnk	286	44	.	.	.
cord-321607-3r736dnk	287	1	Since	since	IN
cord-321607-3r736dnk	287	2	the	the	DT
cord-321607-3r736dnk	287	3	N	n	CD
cord-321607-3r736dnk	287	4	-	-	HYPH
cord-321607-3r736dnk	287	5	terminus	terminus	NN
cord-321607-3r736dnk	287	6	of	of	IN
cord-321607-3r736dnk	287	7	RNase	RNase	NNP
cord-321607-3r736dnk	287	8	-	-	HYPH
cord-321607-3r736dnk	287	9	L	L	NNP
cord-321607-3r736dnk	287	10	is	be	VBZ
cord-321607-3r736dnk	287	11	bound	bind	VBN
cord-321607-3r736dnk	287	12	and	and	CC
cord-321607-3r736dnk	287	13	then	then	RB
cord-321607-3r736dnk	287	14	released	release	VBN
cord-321607-3r736dnk	287	15	by	by	IN
cord-321607-3r736dnk	287	16	FLNA	FLNA	NNP
cord-321607-3r736dnk	287	17	and	and	CC
cord-321607-3r736dnk	287	18	the	the	DT
cord-321607-3r736dnk	287	19	C	c	NN
cord-321607-3r736dnk	287	20	-	-	HYPH
cord-321607-3r736dnk	287	21	terminus	terminus	NN
cord-321607-3r736dnk	287	22	of	of	IN
cord-321607-3r736dnk	287	23	RNase	RNase	NNP
cord-321607-3r736dnk	287	24	-	-	HYPH
cord-321607-3r736dnk	287	25	L	L	NNP
cord-321607-3r736dnk	287	26	is	be	VBZ
cord-321607-3r736dnk	287	27	still	still	RB
cord-321607-3r736dnk	287	28	capable	capable	JJ
cord-321607-3r736dnk	287	29	of	of	IN
cord-321607-3r736dnk	287	30	binding	bind	VBG
cord-321607-3r736dnk	287	31	to	to	IN
cord-321607-3r736dnk	287	32	LNX	LNX	NNP
cord-321607-3r736dnk	287	33	,	,	,
cord-321607-3r736dnk	287	34	it	-PRON-	PRP
cord-321607-3r736dnk	287	35	is	be	VBZ
cord-321607-3r736dnk	287	36	likely	likely	JJ
cord-321607-3r736dnk	287	37	that	that	IN
cord-321607-3r736dnk	287	38	2	2	CD
cord-321607-3r736dnk	287	39	-	-	HYPH
cord-321607-3r736dnk	287	40	5A	5a	NN
cord-321607-3r736dnk	287	41	binding	bind	VBG
cord-321607-3r736dnk	287	42	to	to	IN
cord-321607-3r736dnk	287	43	RNase	RNase	NNP
cord-321607-3r736dnk	287	44	-	-	HYPH
cord-321607-3r736dnk	287	45	L	l	NN
cord-321607-3r736dnk	287	46	causes	cause	VBZ
cord-321607-3r736dnk	287	47	a	a	DT
cord-321607-3r736dnk	287	48	conformational	conformational	JJ
cord-321607-3r736dnk	287	49	change	change	NN
cord-321607-3r736dnk	287	50	to	to	IN
cord-321607-3r736dnk	287	51	LNX	lnx	NN
cord-321607-3r736dnk	287	52	-	-	HYPH
cord-321607-3r736dnk	287	53	bound	bind	VBN
cord-321607-3r736dnk	287	54	RNase	RNase	NNP
cord-321607-3r736dnk	287	55	-	-	HYPH
cord-321607-3r736dnk	287	56	L	L	NNP
cord-321607-3r736dnk	287	57	that	that	WDT
cord-321607-3r736dnk	287	58	induces	induce	VBZ
cord-321607-3r736dnk	287	59	Collectively	collectively	RB
cord-321607-3r736dnk	287	60	,	,	,
cord-321607-3r736dnk	287	61	the	the	DT
cord-321607-3r736dnk	287	62	data	data	NN
cord-321607-3r736dnk	287	63	suggests	suggest	VBZ
cord-321607-3r736dnk	287	64	a	a	DT
cord-321607-3r736dnk	287	65	model	model	NN
cord-321607-3r736dnk	287	66	in	in	IN
cord-321607-3r736dnk	287	67	which	which	WDT
cord-321607-3r736dnk	287	68	FLNA	FLNA	NNP
cord-321607-3r736dnk	287	69	,	,	,
cord-321607-3r736dnk	287	70	LNX	LNX	NNP
cord-321607-3r736dnk	287	71	,	,	,
cord-321607-3r736dnk	287	72	and	and	CC
cord-321607-3r736dnk	287	73	RNase	RNase	NNP
cord-321607-3r736dnk	287	74	-	-	HYPH
cord-321607-3r736dnk	287	75	L	l	NN
cord-321607-3r736dnk	287	76	form	form	VB
cord-321607-3r736dnk	287	77	a	a	DT
cord-321607-3r736dnk	287	78	complex	complex	NN
cord-321607-3r736dnk	287	79	associated	associate	VBN
cord-321607-3r736dnk	287	80	with	with	IN
cord-321607-3r736dnk	287	81	the	the	DT
cord-321607-3r736dnk	287	82	actin	actin	NN
cord-321607-3r736dnk	287	83	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	287	84	.	.	.
cord-321607-3r736dnk	288	1	During	during	IN
cord-321607-3r736dnk	288	2	resting	rest	VBG
cord-321607-3r736dnk	288	3	conditions	condition	NNS
cord-321607-3r736dnk	288	4	,	,	,
cord-321607-3r736dnk	288	5	this	this	DT
cord-321607-3r736dnk	288	6	complex	complex	NN
cord-321607-3r736dnk	288	7	supports	support	VBZ
cord-321607-3r736dnk	288	8	membrane	membrane	NN
cord-321607-3r736dnk	288	9	integrity	integrity	NN
cord-321607-3r736dnk	288	10	to	to	TO
cord-321607-3r736dnk	288	11	inhibit	inhibit	VB
cord-321607-3r736dnk	288	12	endocytosis	endocytosis	NN
cord-321607-3r736dnk	288	13	or	or	CC
cord-321607-3r736dnk	288	14	viral	viral	JJ
cord-321607-3r736dnk	288	15	entry	entry	NN
cord-321607-3r736dnk	288	16	into	into	IN
cord-321607-3r736dnk	288	17	the	the	DT
cord-321607-3r736dnk	288	18	cell	cell	NN
cord-321607-3r736dnk	288	19	.	.	.
cord-321607-3r736dnk	289	1	If	if	IN
cord-321607-3r736dnk	289	2	the	the	DT
cord-321607-3r736dnk	289	3	virus	virus	NN
cord-321607-3r736dnk	289	4	breaches	breach	VBZ
cord-321607-3r736dnk	289	5	the	the	DT
cord-321607-3r736dnk	289	6	membrane	membrane	NN
cord-321607-3r736dnk	289	7	barrier	barrier	NN
cord-321607-3r736dnk	289	8	and	and	CC
cord-321607-3r736dnk	289	9	activates	activate	VBZ
cord-321607-3r736dnk	289	10	OAS	OAS	NNP
cord-321607-3r736dnk	289	11	to	to	TO
cord-321607-3r736dnk	289	12	produce	produce	VB
cord-321607-3r736dnk	289	13	2	2	CD
cord-321607-3r736dnk	289	14	-	-	HYPH
cord-321607-3r736dnk	289	15	5A	5a	NN
cord-321607-3r736dnk	289	16	,	,	,
cord-321607-3r736dnk	289	17	then	then	RB
cord-321607-3r736dnk	289	18	the	the	DT
cord-321607-3r736dnk	289	19	RNase	RNase	NNP
cord-321607-3r736dnk	289	20	-	-	HYPH
cord-321607-3r736dnk	289	21	L	L	NNP
cord-321607-3r736dnk	289	22	-	-	HYPH
cord-321607-3r736dnk	289	23	FLNA	FLNA	NNP
cord-321607-3r736dnk	289	24	interaction	interaction	NN
cord-321607-3r736dnk	289	25	is	be	VBZ
cord-321607-3r736dnk	289	26	abolished	abolish	VBN
cord-321607-3r736dnk	289	27	and	and	CC
cord-321607-3r736dnk	289	28	RNase	RNase	NNP
cord-321607-3r736dnk	289	29	-	-	HYPH
cord-321607-3r736dnk	289	30	L	L	NNP
cord-321607-3r736dnk	289	31	is	be	VBZ
cord-321607-3r736dnk	289	32	released	release	VBN
cord-321607-3r736dnk	289	33	from	from	IN
cord-321607-3r736dnk	289	34	the	the	DT
cord-321607-3r736dnk	289	35	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	289	36	(	(	-LRB-
cord-321607-3r736dnk	289	37	[	[	-LRB-
cord-321607-3r736dnk	289	38	23	23	CD
cord-321607-3r736dnk	289	39	]	]	-RRB-
cord-321607-3r736dnk	289	40	and	and	CC
cord-321607-3r736dnk	289	41	Figure	Figure	NNP
cord-321607-3r736dnk	289	42	4	4	CD
cord-321607-3r736dnk	289	43	)	)	-RRB-
cord-321607-3r736dnk	289	44	.	.	.
cord-321607-3r736dnk	290	1	Since	since	IN
cord-321607-3r736dnk	290	2	the	the	DT
cord-321607-3r736dnk	290	3	N	n	CD
cord-321607-3r736dnk	290	4	-	-	HYPH
cord-321607-3r736dnk	290	5	terminus	terminus	NN
cord-321607-3r736dnk	290	6	of	of	IN
cord-321607-3r736dnk	290	7	RNase	RNase	NNP
cord-321607-3r736dnk	290	8	-	-	HYPH
cord-321607-3r736dnk	290	9	L	L	NNP
cord-321607-3r736dnk	290	10	is	be	VBZ
cord-321607-3r736dnk	290	11	bound	bind	VBN
cord-321607-3r736dnk	290	12	and	and	CC
cord-321607-3r736dnk	290	13	then	then	RB
cord-321607-3r736dnk	290	14	released	release	VBN
cord-321607-3r736dnk	290	15	by	by	IN
cord-321607-3r736dnk	290	16	FLNA	FLNA	NNP
cord-321607-3r736dnk	290	17	and	and	CC
cord-321607-3r736dnk	290	18	the	the	DT
cord-321607-3r736dnk	290	19	C	c	NN
cord-321607-3r736dnk	290	20	-	-	HYPH
cord-321607-3r736dnk	290	21	terminus	terminus	NN
cord-321607-3r736dnk	290	22	of	of	IN
cord-321607-3r736dnk	290	23	RNase	RNase	NNP
cord-321607-3r736dnk	290	24	-	-	HYPH
cord-321607-3r736dnk	290	25	L	L	NNP
cord-321607-3r736dnk	290	26	is	be	VBZ
cord-321607-3r736dnk	290	27	still	still	RB
cord-321607-3r736dnk	290	28	capable	capable	JJ
cord-321607-3r736dnk	290	29	of	of	IN
cord-321607-3r736dnk	290	30	binding	bind	VBG
cord-321607-3r736dnk	290	31	to	to	IN
cord-321607-3r736dnk	290	32	LNX	LNX	NNP
cord-321607-3r736dnk	290	33	,	,	,
cord-321607-3r736dnk	290	34	it	-PRON-	PRP
cord-321607-3r736dnk	290	35	is	be	VBZ
cord-321607-3r736dnk	290	36	likely	likely	JJ
cord-321607-3r736dnk	290	37	that	that	IN
cord-321607-3r736dnk	290	38	2	2	CD
cord-321607-3r736dnk	290	39	-	-	HYPH
cord-321607-3r736dnk	290	40	5A	5a	NN
cord-321607-3r736dnk	290	41	binding	bind	VBG
cord-321607-3r736dnk	290	42	to	to	IN
cord-321607-3r736dnk	290	43	RNase	RNase	NNP
cord-321607-3r736dnk	290	44	-	-	HYPH
cord-321607-3r736dnk	290	45	L	l	NN
cord-321607-3r736dnk	290	46	causes	cause	VBZ
cord-321607-3r736dnk	290	47	a	a	DT
cord-321607-3r736dnk	290	48	conformational	conformational	JJ
cord-321607-3r736dnk	290	49	change	change	NN
cord-321607-3r736dnk	290	50	to	to	IN
cord-321607-3r736dnk	290	51	LNX	lnx	NN
cord-321607-3r736dnk	290	52	-	-	HYPH
cord-321607-3r736dnk	290	53	bound	bind	VBN
cord-321607-3r736dnk	290	54	RNase	RNase	NNP
cord-321607-3r736dnk	290	55	-	-	HYPH
cord-321607-3r736dnk	290	56	L	L	NNP
cord-321607-3r736dnk	290	57	that	that	WDT
cord-321607-3r736dnk	290	58	induces	induce	VBZ
cord-321607-3r736dnk	290	59	the	the	DT
cord-321607-3r736dnk	290	60	dissociation	dissociation	NN
cord-321607-3r736dnk	290	61	of	of	IN
cord-321607-3r736dnk	290	62	FLNA	FLNA	NNP
cord-321607-3r736dnk	290	63	from	from	IN
cord-321607-3r736dnk	290	64	LNX	LNX	NNP
cord-321607-3r736dnk	290	65	.	.	.
cord-321607-3r736dnk	291	1	This	this	DT
cord-321607-3r736dnk	291	2	may	may	MD
cord-321607-3r736dnk	291	3	not	not	RB
cord-321607-3r736dnk	291	4	only	only	RB
cord-321607-3r736dnk	291	5	release	release	VB
cord-321607-3r736dnk	291	6	RNase	RNase	NNP
cord-321607-3r736dnk	291	7	-	-	HYPH
cord-321607-3r736dnk	291	8	L	l	NN
cord-321607-3r736dnk	291	9	from	from	IN
cord-321607-3r736dnk	291	10	FLNA	FLNA	NNP
cord-321607-3r736dnk	291	11	but	but	CC
cord-321607-3r736dnk	291	12	also	also	RB
cord-321607-3r736dnk	291	13	alter	alter	VB
cord-321607-3r736dnk	291	14	LNX	lnx	NN
cord-321607-3r736dnk	291	15	localization	localization	NN
cord-321607-3r736dnk	291	16	.	.	.
cord-321607-3r736dnk	292	1	RNase	RNase	NNP
cord-321607-3r736dnk	292	2	-	-	HYPH
cord-321607-3r736dnk	292	3	L	L	NNP
cord-321607-3r736dnk	292	4	is	be	VBZ
cord-321607-3r736dnk	292	5	then	then	RB
cord-321607-3r736dnk	292	6	free	free	JJ
cord-321607-3r736dnk	292	7	to	to	IN
cord-321607-3r736dnk	292	8	oligomerize	oligomerize	VB
cord-321607-3r736dnk	292	9	into	into	IN
cord-321607-3r736dnk	292	10	an	an	DT
cord-321607-3r736dnk	292	11	active	active	JJ
cord-321607-3r736dnk	292	12	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	292	13	,	,	,
cord-321607-3r736dnk	292	14	cleave	cleave	VB
cord-321607-3r736dnk	292	15	viral	viral	JJ
cord-321607-3r736dnk	292	16	and	and	CC
cord-321607-3r736dnk	292	17	cellular	cellular	JJ
cord-321607-3r736dnk	292	18	RNAs	rna	NNS
cord-321607-3r736dnk	292	19	into	into	IN
cord-321607-3r736dnk	292	20	RIG	rig	NN
cord-321607-3r736dnk	292	21	-	-	:
cord-321607-3r736dnk	292	22	I	-PRON-	PRP
cord-321607-3r736dnk	292	23	activators	activator	NNS
cord-321607-3r736dnk	292	24	,	,	,
cord-321607-3r736dnk	292	25	and	and	CC
cord-321607-3r736dnk	292	26	induce	induce	VB
cord-321607-3r736dnk	292	27	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	292	28	expression	expression	NN
cord-321607-3r736dnk	292	29	to	to	TO
cord-321607-3r736dnk	292	30	create	create	VB
cord-321607-3r736dnk	292	31	a	a	DT
cord-321607-3r736dnk	292	32	broader	broad	JJR
cord-321607-3r736dnk	292	33	antiviral	antiviral	JJ
cord-321607-3r736dnk	292	34	state	state	NN
cord-321607-3r736dnk	292	35	(	(	-LRB-
cord-321607-3r736dnk	292	36	Figure	figure	NN
cord-321607-3r736dnk	292	37	5	5	CD
cord-321607-3r736dnk	292	38	)	)	-RRB-
cord-321607-3r736dnk	292	39	.	.	.
cord-321607-3r736dnk	293	1	the	the	DT
cord-321607-3r736dnk	293	2	dissociation	dissociation	NN
cord-321607-3r736dnk	293	3	of	of	IN
cord-321607-3r736dnk	293	4	FLNA	FLNA	NNP
cord-321607-3r736dnk	293	5	from	from	IN
cord-321607-3r736dnk	293	6	LNX	LNX	NNP
cord-321607-3r736dnk	293	7	.	.	.
cord-321607-3r736dnk	294	1	This	this	DT
cord-321607-3r736dnk	294	2	may	may	MD
cord-321607-3r736dnk	294	3	not	not	RB
cord-321607-3r736dnk	294	4	only	only	RB
cord-321607-3r736dnk	294	5	release	release	VB
cord-321607-3r736dnk	294	6	RNase	RNase	NNP
cord-321607-3r736dnk	294	7	-	-	HYPH
cord-321607-3r736dnk	294	8	L	l	NN
cord-321607-3r736dnk	294	9	from	from	IN
cord-321607-3r736dnk	294	10	FLNA	FLNA	NNP
cord-321607-3r736dnk	294	11	but	but	CC
cord-321607-3r736dnk	294	12	also	also	RB
cord-321607-3r736dnk	294	13	alter	alter	VB
cord-321607-3r736dnk	294	14	LNX	lnx	NN
cord-321607-3r736dnk	294	15	localization	localization	NN
cord-321607-3r736dnk	294	16	.	.	.
cord-321607-3r736dnk	295	1	RNase	RNase	NNP
cord-321607-3r736dnk	295	2	-	-	HYPH
cord-321607-3r736dnk	295	3	L	L	NNP
cord-321607-3r736dnk	295	4	is	be	VBZ
cord-321607-3r736dnk	295	5	then	then	RB
cord-321607-3r736dnk	295	6	free	free	JJ
cord-321607-3r736dnk	295	7	to	to	IN
cord-321607-3r736dnk	295	8	oligomerize	oligomerize	VB
cord-321607-3r736dnk	295	9	into	into	IN
cord-321607-3r736dnk	295	10	an	an	DT
cord-321607-3r736dnk	295	11	active	active	JJ
cord-321607-3r736dnk	295	12	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	295	13	,	,	,
cord-321607-3r736dnk	295	14	cleave	cleave	VB
cord-321607-3r736dnk	295	15	viral	viral	JJ
cord-321607-3r736dnk	295	16	and	and	CC
cord-321607-3r736dnk	295	17	cellular	cellular	JJ
cord-321607-3r736dnk	295	18	RNAs	rna	NNS
cord-321607-3r736dnk	295	19	into	into	IN
cord-321607-3r736dnk	295	20	RIG	rig	NN
cord-321607-3r736dnk	295	21	-	-	:
cord-321607-3r736dnk	295	22	I	-PRON-	PRP
cord-321607-3r736dnk	295	23	activators	activator	NNS
cord-321607-3r736dnk	295	24	,	,	,
cord-321607-3r736dnk	295	25	and	and	CC
cord-321607-3r736dnk	295	26	induce	induce	VB
cord-321607-3r736dnk	295	27	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	295	28	expression	expression	NN
cord-321607-3r736dnk	295	29	to	to	TO
cord-321607-3r736dnk	295	30	create	create	VB
cord-321607-3r736dnk	295	31	a	a	DT
cord-321607-3r736dnk	295	32	broader	broad	JJR
cord-321607-3r736dnk	295	33	antiviral	antiviral	JJ
cord-321607-3r736dnk	295	34	state	state	NN
cord-321607-3r736dnk	295	35	(	(	-LRB-
cord-321607-3r736dnk	295	36	Figure	figure	NN
cord-321607-3r736dnk	295	37	5	5	CD
cord-321607-3r736dnk	295	38	)	)	-RRB-
cord-321607-3r736dnk	295	39	.	.	.
cord-321607-3r736dnk	295	40	 	 	_SP
cord-321607-3r736dnk	296	1	This	this	DT
cord-321607-3r736dnk	296	2	model	model	NN
cord-321607-3r736dnk	296	3	of	of	IN
cord-321607-3r736dnk	296	4	RNase	RNase	NNP
cord-321607-3r736dnk	296	5	-	-	HYPH
cord-321607-3r736dnk	296	6	L	l	NN
cord-321607-3r736dnk	296	7	function	function	NN
cord-321607-3r736dnk	296	8	parallels	parallel	VBZ
cord-321607-3r736dnk	296	9	an	an	DT
cord-321607-3r736dnk	296	10	emerging	emerge	VBG
cord-321607-3r736dnk	296	11	network	network	NN
cord-321607-3r736dnk	296	12	of	of	IN
cord-321607-3r736dnk	296	13	innate	innate	JJ
cord-321607-3r736dnk	296	14	immune	immune	JJ
cord-321607-3r736dnk	296	15	proteins	protein	NNS
cord-321607-3r736dnk	296	16	that	that	WDT
cord-321607-3r736dnk	296	17	are	be	VBP
cord-321607-3r736dnk	296	18	directly	directly	RB
cord-321607-3r736dnk	296	19	associated	associate	VBN
cord-321607-3r736dnk	296	20	with	with	IN
cord-321607-3r736dnk	296	21	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	296	22	components	component	NNS
cord-321607-3r736dnk	296	23	to	to	TO
cord-321607-3r736dnk	296	24	serve	serve	VB
cord-321607-3r736dnk	296	25	roles	role	NNS
cord-321607-3r736dnk	296	26	both	both	CC
cord-321607-3r736dnk	296	27	as	as	IN
cord-321607-3r736dnk	296	28	a	a	DT
cord-321607-3r736dnk	296	29	barrier	barrier	NN
cord-321607-3r736dnk	296	30	to	to	IN
cord-321607-3r736dnk	296	31	pathogen	pathogen	NN
cord-321607-3r736dnk	296	32	infection	infection	NN
cord-321607-3r736dnk	296	33	and	and	CC
cord-321607-3r736dnk	296	34	to	to	TO
cord-321607-3r736dnk	296	35	initiate	initiate	VB
cord-321607-3r736dnk	296	36	signaling	signal	VBG
cord-321607-3r736dnk	296	37	and	and	CC
cord-321607-3r736dnk	296	38	effector	effector	NN
cord-321607-3r736dnk	296	39	functions	function	NNS
cord-321607-3r736dnk	296	40	upon	upon	IN
cord-321607-3r736dnk	296	41	infection	infection	NN
cord-321607-3r736dnk	296	42	.	.	.
cord-321607-3r736dnk	297	1	Although	although	IN
cord-321607-3r736dnk	297	2	each	each	DT
cord-321607-3r736dnk	297	3	protein	protein	NN
cord-321607-3r736dnk	297	4	has	have	VBZ
cord-321607-3r736dnk	297	5	been	be	VBN
cord-321607-3r736dnk	297	6	identified	identify	VBN
cord-321607-3r736dnk	297	7	and	and	CC
cord-321607-3r736dnk	297	8	characterized	characterize	VBN
cord-321607-3r736dnk	297	9	singularly	singularly	RB
cord-321607-3r736dnk	297	10	,	,	,
cord-321607-3r736dnk	297	11	this	this	DT
cord-321607-3r736dnk	297	12	growing	grow	VBG
cord-321607-3r736dnk	297	13	trend	trend	NN
cord-321607-3r736dnk	297	14	may	may	MD
cord-321607-3r736dnk	297	15	indicate	indicate	VB
cord-321607-3r736dnk	297	16	broader	broad	JJR
cord-321607-3r736dnk	297	17	relationships	relationship	NNS
cord-321607-3r736dnk	297	18	the	the	DT
cord-321607-3r736dnk	297	19	dissociation	dissociation	NN
cord-321607-3r736dnk	297	20	of	of	IN
cord-321607-3r736dnk	297	21	FLNA	FLNA	NNP
cord-321607-3r736dnk	297	22	from	from	IN
cord-321607-3r736dnk	297	23	LNX	LNX	NNP
cord-321607-3r736dnk	297	24	.	.	.
cord-321607-3r736dnk	298	1	This	this	DT
cord-321607-3r736dnk	298	2	may	may	MD
cord-321607-3r736dnk	298	3	not	not	RB
cord-321607-3r736dnk	298	4	only	only	RB
cord-321607-3r736dnk	298	5	release	release	VB
cord-321607-3r736dnk	298	6	RNase	RNase	NNP
cord-321607-3r736dnk	298	7	-	-	HYPH
cord-321607-3r736dnk	298	8	L	l	NN
cord-321607-3r736dnk	298	9	from	from	IN
cord-321607-3r736dnk	298	10	FLNA	FLNA	NNP
cord-321607-3r736dnk	298	11	but	but	CC
cord-321607-3r736dnk	298	12	also	also	RB
cord-321607-3r736dnk	298	13	alter	alter	VB
cord-321607-3r736dnk	298	14	LNX	lnx	NN
cord-321607-3r736dnk	298	15	localization	localization	NN
cord-321607-3r736dnk	298	16	.	.	.
cord-321607-3r736dnk	299	1	RNase	RNase	NNP
cord-321607-3r736dnk	299	2	-	-	HYPH
cord-321607-3r736dnk	299	3	L	L	NNP
cord-321607-3r736dnk	299	4	is	be	VBZ
cord-321607-3r736dnk	299	5	then	then	RB
cord-321607-3r736dnk	299	6	free	free	JJ
cord-321607-3r736dnk	299	7	to	to	IN
cord-321607-3r736dnk	299	8	oligomerize	oligomerize	VB
cord-321607-3r736dnk	299	9	into	into	IN
cord-321607-3r736dnk	299	10	an	an	DT
cord-321607-3r736dnk	299	11	active	active	JJ
cord-321607-3r736dnk	299	12	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	299	13	,	,	,
cord-321607-3r736dnk	299	14	cleave	cleave	VB
cord-321607-3r736dnk	299	15	viral	viral	JJ
cord-321607-3r736dnk	299	16	and	and	CC
cord-321607-3r736dnk	299	17	cellular	cellular	JJ
cord-321607-3r736dnk	299	18	RNAs	rna	NNS
cord-321607-3r736dnk	299	19	into	into	IN
cord-321607-3r736dnk	299	20	RIG	rig	NN
cord-321607-3r736dnk	299	21	-	-	:
cord-321607-3r736dnk	299	22	I	-PRON-	PRP
cord-321607-3r736dnk	299	23	activators	activator	NNS
cord-321607-3r736dnk	299	24	,	,	,
cord-321607-3r736dnk	299	25	and	and	CC
cord-321607-3r736dnk	299	26	induce	induce	VB
cord-321607-3r736dnk	299	27	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	299	28	expression	expression	NN
cord-321607-3r736dnk	299	29	to	to	TO
cord-321607-3r736dnk	299	30	create	create	VB
cord-321607-3r736dnk	299	31	a	a	DT
cord-321607-3r736dnk	299	32	broader	broad	JJR
cord-321607-3r736dnk	299	33	antiviral	antiviral	JJ
cord-321607-3r736dnk	299	34	state	state	NN
cord-321607-3r736dnk	299	35	(	(	-LRB-
cord-321607-3r736dnk	299	36	Figure	figure	NN
cord-321607-3r736dnk	299	37	5	5	CD
cord-321607-3r736dnk	299	38	)	)	-RRB-
cord-321607-3r736dnk	299	39	.	.	.
cord-321607-3r736dnk	299	40	 	 	_SP
cord-321607-3r736dnk	300	1	This	this	DT
cord-321607-3r736dnk	300	2	model	model	NN
cord-321607-3r736dnk	300	3	of	of	IN
cord-321607-3r736dnk	300	4	RNase	RNase	NNP
cord-321607-3r736dnk	300	5	-	-	HYPH
cord-321607-3r736dnk	300	6	L	l	NN
cord-321607-3r736dnk	300	7	function	function	NN
cord-321607-3r736dnk	300	8	parallels	parallel	VBZ
cord-321607-3r736dnk	300	9	an	an	DT
cord-321607-3r736dnk	300	10	emerging	emerge	VBG
cord-321607-3r736dnk	300	11	network	network	NN
cord-321607-3r736dnk	300	12	of	of	IN
cord-321607-3r736dnk	300	13	innate	innate	JJ
cord-321607-3r736dnk	300	14	immune	immune	JJ
cord-321607-3r736dnk	300	15	proteins	protein	NNS
cord-321607-3r736dnk	300	16	that	that	WDT
cord-321607-3r736dnk	300	17	are	be	VBP
cord-321607-3r736dnk	300	18	directly	directly	RB
cord-321607-3r736dnk	300	19	associated	associate	VBN
cord-321607-3r736dnk	300	20	with	with	IN
cord-321607-3r736dnk	300	21	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	300	22	components	component	NNS
cord-321607-3r736dnk	300	23	to	to	TO
cord-321607-3r736dnk	300	24	serve	serve	VB
cord-321607-3r736dnk	300	25	roles	role	NNS
cord-321607-3r736dnk	300	26	both	both	CC
cord-321607-3r736dnk	300	27	as	as	IN
cord-321607-3r736dnk	300	28	a	a	DT
cord-321607-3r736dnk	300	29	barrier	barrier	NN
cord-321607-3r736dnk	300	30	to	to	IN
cord-321607-3r736dnk	300	31	pathogen	pathogen	NN
cord-321607-3r736dnk	300	32	infection	infection	NN
cord-321607-3r736dnk	300	33	and	and	CC
cord-321607-3r736dnk	300	34	to	to	TO
cord-321607-3r736dnk	300	35	initiate	initiate	VB
cord-321607-3r736dnk	300	36	signaling	signal	VBG
cord-321607-3r736dnk	300	37	and	and	CC
cord-321607-3r736dnk	300	38	effector	effector	NN
cord-321607-3r736dnk	300	39	functions	function	NNS
cord-321607-3r736dnk	300	40	upon	upon	IN
cord-321607-3r736dnk	300	41	infection	infection	NN
cord-321607-3r736dnk	300	42	.	.	.
cord-321607-3r736dnk	301	1	Although	although	IN
cord-321607-3r736dnk	301	2	each	each	DT
cord-321607-3r736dnk	301	3	protein	protein	NN
cord-321607-3r736dnk	301	4	has	have	VBZ
cord-321607-3r736dnk	301	5	been	be	VBN
cord-321607-3r736dnk	301	6	identified	identify	VBN
cord-321607-3r736dnk	301	7	and	and	CC
cord-321607-3r736dnk	301	8	characterized	characterize	VBN
cord-321607-3r736dnk	301	9	singularly	singularly	RB
cord-321607-3r736dnk	301	10	,	,	,
cord-321607-3r736dnk	301	11	this	this	DT
cord-321607-3r736dnk	301	12	growing	grow	VBG
cord-321607-3r736dnk	301	13	trend	trend	NN
cord-321607-3r736dnk	301	14	may	may	MD
cord-321607-3r736dnk	301	15	indicate	indicate	VB
cord-321607-3r736dnk	301	16	broader	broad	JJR
cord-321607-3r736dnk	301	17	relationships	relationship	NNS
cord-321607-3r736dnk	301	18	 	 	_SP
cord-321607-3r736dnk	302	1	This	this	DT
cord-321607-3r736dnk	302	2	model	model	NN
cord-321607-3r736dnk	302	3	of	of	IN
cord-321607-3r736dnk	302	4	RNase	RNase	NNP
cord-321607-3r736dnk	302	5	-	-	HYPH
cord-321607-3r736dnk	302	6	L	l	NN
cord-321607-3r736dnk	302	7	function	function	NN
cord-321607-3r736dnk	302	8	parallels	parallel	VBZ
cord-321607-3r736dnk	302	9	an	an	DT
cord-321607-3r736dnk	302	10	emerging	emerge	VBG
cord-321607-3r736dnk	302	11	network	network	NN
cord-321607-3r736dnk	302	12	of	of	IN
cord-321607-3r736dnk	302	13	innate	innate	JJ
cord-321607-3r736dnk	302	14	immune	immune	JJ
cord-321607-3r736dnk	302	15	proteins	protein	NNS
cord-321607-3r736dnk	302	16	that	that	WDT
cord-321607-3r736dnk	302	17	are	be	VBP
cord-321607-3r736dnk	302	18	directly	directly	RB
cord-321607-3r736dnk	302	19	associated	associate	VBN
cord-321607-3r736dnk	302	20	with	with	IN
cord-321607-3r736dnk	302	21	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	302	22	components	component	NNS
cord-321607-3r736dnk	302	23	to	to	TO
cord-321607-3r736dnk	302	24	serve	serve	VB
cord-321607-3r736dnk	302	25	roles	role	NNS
cord-321607-3r736dnk	302	26	both	both	CC
cord-321607-3r736dnk	302	27	as	as	IN
cord-321607-3r736dnk	302	28	a	a	DT
cord-321607-3r736dnk	302	29	barrier	barrier	NN
cord-321607-3r736dnk	302	30	to	to	IN
cord-321607-3r736dnk	302	31	pathogen	pathogen	NN
cord-321607-3r736dnk	302	32	infection	infection	NN
cord-321607-3r736dnk	302	33	and	and	CC
cord-321607-3r736dnk	302	34	to	to	TO
cord-321607-3r736dnk	302	35	initiate	initiate	VB
cord-321607-3r736dnk	302	36	signaling	signal	VBG
cord-321607-3r736dnk	302	37	and	and	CC
cord-321607-3r736dnk	302	38	effector	effector	NN
cord-321607-3r736dnk	302	39	functions	function	NNS
cord-321607-3r736dnk	302	40	upon	upon	IN
cord-321607-3r736dnk	302	41	infection	infection	NN
cord-321607-3r736dnk	302	42	.	.	.
cord-321607-3r736dnk	303	1	Although	although	IN
cord-321607-3r736dnk	303	2	each	each	DT
cord-321607-3r736dnk	303	3	protein	protein	NN
cord-321607-3r736dnk	303	4	has	have	VBZ
cord-321607-3r736dnk	303	5	been	be	VBN
cord-321607-3r736dnk	303	6	identified	identify	VBN
cord-321607-3r736dnk	303	7	and	and	CC
cord-321607-3r736dnk	303	8	characterized	characterize	VBN
cord-321607-3r736dnk	303	9	singularly	singularly	RB
cord-321607-3r736dnk	303	10	,	,	,
cord-321607-3r736dnk	303	11	this	this	DT
cord-321607-3r736dnk	303	12	growing	grow	VBG
cord-321607-3r736dnk	303	13	trend	trend	NN
cord-321607-3r736dnk	303	14	may	may	MD
cord-321607-3r736dnk	303	15	indicate	indicate	VB
cord-321607-3r736dnk	303	16	broader	broad	JJR
cord-321607-3r736dnk	303	17	relationships	relationship	NNS
cord-321607-3r736dnk	303	18	between	between	IN
cord-321607-3r736dnk	303	19	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	303	20	functions	function	NNS
cord-321607-3r736dnk	303	21	and	and	CC
cord-321607-3r736dnk	303	22	innate	innate	JJ
cord-321607-3r736dnk	303	23	immune	immune	JJ
cord-321607-3r736dnk	303	24	regulation	regulation	NN
cord-321607-3r736dnk	303	25	and	and	CC
cord-321607-3r736dnk	303	26	activity	activity	NN
cord-321607-3r736dnk	303	27	.	.	.
cord-321607-3r736dnk	304	1	Consistent	consistent	JJ
cord-321607-3r736dnk	304	2	with	with	IN
cord-321607-3r736dnk	304	3	this	this	DT
cord-321607-3r736dnk	304	4	view	view	NN
cord-321607-3r736dnk	304	5	,	,	,
cord-321607-3r736dnk	304	6	bacteria	bacteria	NNS
cord-321607-3r736dnk	304	7	and	and	CC
cord-321607-3r736dnk	304	8	viruses	virus	NNS
cord-321607-3r736dnk	304	9	both	both	DT
cord-321607-3r736dnk	304	10	modulate	modulate	VBP
cord-321607-3r736dnk	304	11	actin	actin	NN
cord-321607-3r736dnk	304	12	polymerization	polymerization	NN
cord-321607-3r736dnk	304	13	as	as	IN
cord-321607-3r736dnk	304	14	central	central	JJ
cord-321607-3r736dnk	304	15	components	component	NNS
cord-321607-3r736dnk	304	16	of	of	IN
cord-321607-3r736dnk	304	17	infection	infection	NN
cord-321607-3r736dnk	304	18	and	and	CC
cord-321607-3r736dnk	304	19	replication	replication	NN
cord-321607-3r736dnk	304	20	[	[	-LRB-
cord-321607-3r736dnk	304	21	133	133	CD
cord-321607-3r736dnk	304	22	,	,	,
cord-321607-3r736dnk	304	23	134	134	CD
cord-321607-3r736dnk	304	24	]	]	-RRB-
cord-321607-3r736dnk	304	25	.	.	.
cord-321607-3r736dnk	305	1	Furthermore	furthermore	RB
cord-321607-3r736dnk	305	2	,	,	,
cord-321607-3r736dnk	305	3	perturbation	perturbation	NN
cord-321607-3r736dnk	305	4	of	of	IN
cord-321607-3r736dnk	305	5	the	the	DT
cord-321607-3r736dnk	305	6	actin	actin	NN
cord-321607-3r736dnk	305	7	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	305	8	activates	activate	VBZ
cord-321607-3r736dnk	305	9	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	305	10	-	-	HYPH
cord-321607-3r736dnk	305	11	associated	associate	VBN
cord-321607-3r736dnk	305	12	PRRs	prr	NNS
cord-321607-3r736dnk	305	13	[	[	-LRB-
cord-321607-3r736dnk	305	14	135	135	CD
cord-321607-3r736dnk	305	15	]	]	-RRB-
cord-321607-3r736dnk	305	16	[	[	-LRB-
cord-321607-3r736dnk	305	17	136	136	CD
cord-321607-3r736dnk	305	18	]	]	-RRB-
cord-321607-3r736dnk	305	19	[	[	-LRB-
cord-321607-3r736dnk	305	20	137	137	CD
cord-321607-3r736dnk	305	21	]	]	-RRB-
cord-321607-3r736dnk	305	22	.	.	.
cord-321607-3r736dnk	306	1	These	these	DT
cord-321607-3r736dnk	306	2	observations	observation	NNS
cord-321607-3r736dnk	306	3	suggest	suggest	VBP
cord-321607-3r736dnk	306	4	that	that	IN
cord-321607-3r736dnk	306	5	the	the	DT
cord-321607-3r736dnk	306	6	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	306	7	may	may	MD
cord-321607-3r736dnk	306	8	serve	serve	VB
cord-321607-3r736dnk	306	9	as	as	IN
cord-321607-3r736dnk	306	10	a	a	DT
cord-321607-3r736dnk	306	11	sensor	sensor	NN
cord-321607-3r736dnk	306	12	for	for	IN
cord-321607-3r736dnk	306	13	infection	infection	NN
cord-321607-3r736dnk	306	14	and	and	CC
cord-321607-3r736dnk	306	15	that	that	IN
cord-321607-3r736dnk	306	16	pathogen	pathogen	NN
cord-321607-3r736dnk	306	17	-	-	HYPH
cord-321607-3r736dnk	306	18	induced	induce	VBN
cord-321607-3r736dnk	306	19	disruption	disruption	NN
cord-321607-3r736dnk	306	20	of	of	IN
cord-321607-3r736dnk	306	21	this	this	DT
cord-321607-3r736dnk	306	22	structural	structural	JJ
cord-321607-3r736dnk	306	23	matrix	matrix	NN
cord-321607-3r736dnk	306	24	serves	serve	VBZ
cord-321607-3r736dnk	306	25	as	as	IN
cord-321607-3r736dnk	306	26	a	a	DT
cord-321607-3r736dnk	306	27	signal	signal	NN
cord-321607-3r736dnk	306	28	to	to	TO
cord-321607-3r736dnk	306	29	activate	activate	VB
cord-321607-3r736dnk	306	30	an	an	DT
cord-321607-3r736dnk	306	31	innate	innate	JJ
cord-321607-3r736dnk	306	32	immune	immune	JJ
cord-321607-3r736dnk	306	33	response	response	NN
cord-321607-3r736dnk	306	34	.	.	.
cord-321607-3r736dnk	307	1	Here	here	RB
cord-321607-3r736dnk	307	2	we	-PRON-	PRP
cord-321607-3r736dnk	307	3	describe	describe	VBP
cord-321607-3r736dnk	307	4	specific	specific	JJ
cord-321607-3r736dnk	307	5	innate	innate	JJ
cord-321607-3r736dnk	307	6	immune	immune	JJ
cord-321607-3r736dnk	307	7	mediators	mediator	NNS
cord-321607-3r736dnk	307	8	and	and	CC
cord-321607-3r736dnk	307	9	their	-PRON-	PRP$
cord-321607-3r736dnk	307	10	proposed	propose	VBN
cord-321607-3r736dnk	307	11	roles	role	NNS
cord-321607-3r736dnk	307	12	in	in	IN
cord-321607-3r736dnk	307	13	this	this	DT
cord-321607-3r736dnk	307	14	model	model	NN
cord-321607-3r736dnk	307	15	(	(	-LRB-
cord-321607-3r736dnk	307	16	summarized	summarize	VBN
cord-321607-3r736dnk	307	17	in	in	IN
cord-321607-3r736dnk	307	18	Table	Table	NNP
cord-321607-3r736dnk	307	19	1	1	CD
cord-321607-3r736dnk	307	20	)	)	-RRB-
cord-321607-3r736dnk	307	21	.	.	.
cord-321607-3r736dnk	308	1	Understanding	understand	VBG
cord-321607-3r736dnk	308	2	these	these	DT
cord-321607-3r736dnk	308	3	interactions	interaction	NNS
cord-321607-3r736dnk	308	4	will	will	MD
cord-321607-3r736dnk	308	5	likely	likely	RB
cord-321607-3r736dnk	308	6	reveal	reveal	VB
cord-321607-3r736dnk	308	7	a	a	DT
cord-321607-3r736dnk	308	8	novel	novel	NN
cord-321607-3r736dnk	308	9	and	and	CC
cord-321607-3r736dnk	308	10	coordinated	coordinated	JJ
cord-321607-3r736dnk	308	11	mechanism	mechanism	NN
cord-321607-3r736dnk	308	12	of	of	IN
cord-321607-3r736dnk	308	13	cellular	cellular	JJ
cord-321607-3r736dnk	308	14	host	host	NN
cord-321607-3r736dnk	308	15	defense	defense	NN
cord-321607-3r736dnk	308	16	.	.	.
cord-321607-3r736dnk	309	1	RIG	rig	NN
cord-321607-3r736dnk	310	1	-I	-i	DT
cord-321607-3r736dnk	310	2	:	:	:
cord-321607-3r736dnk	311	1	Perhaps	perhaps	RB
cord-321607-3r736dnk	311	2	the	the	DT
cord-321607-3r736dnk	311	3	first	first	JJ
cord-321607-3r736dnk	311	4	PRR	PRR	NNP
cord-321607-3r736dnk	311	5	discovered	discover	VBD
cord-321607-3r736dnk	311	6	to	to	TO
cord-321607-3r736dnk	311	7	be	be	VB
cord-321607-3r736dnk	311	8	activated	activate	VBN
cord-321607-3r736dnk	311	9	by	by	IN
cord-321607-3r736dnk	311	10	the	the	DT
cord-321607-3r736dnk	311	11	actin	actin	NN
cord-321607-3r736dnk	311	12	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	312	1	was	be	VBD
cord-321607-3r736dnk	312	2	RIG	rig	NN
cord-321607-3r736dnk	312	3	-	-	HYPH
cord-321607-3r736dnk	312	4	I.	i.	NN
cord-321607-3r736dnk	312	5	RIG	rig	NN
cord-321607-3r736dnk	313	1	-I	-I	NNP
cord-321607-3r736dnk	313	2	was	be	VBD
cord-321607-3r736dnk	313	3	found	find	VBN
cord-321607-3r736dnk	313	4	to	to	TO
cord-321607-3r736dnk	313	5	localize	localize	VB
cord-321607-3r736dnk	313	6	to	to	IN
cord-321607-3r736dnk	313	7	the	the	DT
cord-321607-3r736dnk	313	8	apico	apico	JJ
cord-321607-3r736dnk	313	9	-	-	HYPH
cord-321607-3r736dnk	313	10	lateral	lateral	JJ
cord-321607-3r736dnk	313	11	cell	cell	NN
cord-321607-3r736dnk	313	12	junctions	junction	NNS
cord-321607-3r736dnk	313	13	and	and	CC
cord-321607-3r736dnk	313	14	tight	tight	JJ
cord-321607-3r736dnk	313	15	junctions	junction	NNS
cord-321607-3r736dnk	313	16	of	of	IN
cord-321607-3r736dnk	313	17	polarized	polarized	JJ
cord-321607-3r736dnk	313	18	intestinal	intestinal	JJ
cord-321607-3r736dnk	313	19	epithelial	epithelial	JJ
cord-321607-3r736dnk	313	20	cells	cell	NNS
cord-321607-3r736dnk	313	21	as	as	RB
cord-321607-3r736dnk	313	22	well	well	RB
cord-321607-3r736dnk	313	23	as	as	IN
cord-321607-3r736dnk	313	24	actin	actin	NN
cord-321607-3r736dnk	313	25	-	-	HYPH
cord-321607-3r736dnk	313	26	rich	rich	JJ
cord-321607-3r736dnk	313	27	membrane	membrane	NN
cord-321607-3r736dnk	313	28	ruffles	ruffle	NNS
cord-321607-3r736dnk	313	29	in	in	IN
cord-321607-3r736dnk	313	30	non	non	JJ
cord-321607-3r736dnk	313	31	-	-	JJ
cord-321607-3r736dnk	313	32	polarized	polarized	JJ
cord-321607-3r736dnk	313	33	cells	cell	NNS
cord-321607-3r736dnk	313	34	.	.	.
cord-321607-3r736dnk	314	1	Physiologically	physiologically	RB
cord-321607-3r736dnk	314	2	,	,	,
cord-321607-3r736dnk	314	3	RIG	rig	NN
cord-321607-3r736dnk	314	4	-	-	:
cord-321607-3r736dnk	314	5	I	-PRON-	PRP
cord-321607-3r736dnk	314	6	expression	expression	NN
cord-321607-3r736dnk	314	7	positively	positively	RB
cord-321607-3r736dnk	314	8	correlated	correlate	VBD
cord-321607-3r736dnk	314	9	with	with	IN
cord-321607-3r736dnk	314	10	cell	cell	NN
cord-321607-3r736dnk	314	11	migration	migration	NN
cord-321607-3r736dnk	314	12	,	,	,
cord-321607-3r736dnk	314	13	which	which	WDT
cord-321607-3r736dnk	314	14	requires	require	VBZ
cord-321607-3r736dnk	314	15	both	both	DT
cord-321607-3r736dnk	314	16	actin	actin	NN
cord-321607-3r736dnk	314	17	polymerization	polymerization	NN
cord-321607-3r736dnk	314	18	and	and	CC
cord-321607-3r736dnk	314	19	depolymerization	depolymerization	NN
cord-321607-3r736dnk	314	20	,	,	,
cord-321607-3r736dnk	314	21	indicating	indicate	VBG
cord-321607-3r736dnk	314	22	that	that	IN
cord-321607-3r736dnk	314	23	RIG	rig	NN
cord-321607-3r736dnk	314	24	-	-	:
cord-321607-3r736dnk	314	25	I	-PRON-	PRP
cord-321607-3r736dnk	314	26	may	may	MD
cord-321607-3r736dnk	314	27	contribute	contribute	VB
cord-321607-3r736dnk	314	28	to	to	IN
cord-321607-3r736dnk	314	29	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	314	30	function	function	NN
cord-321607-3r736dnk	314	31	as	as	RB
cord-321607-3r736dnk	314	32	well	well	RB
cord-321607-3r736dnk	314	33	[	[	-LRB-
cord-321607-3r736dnk	314	34	137	137	CD
cord-321607-3r736dnk	314	35	]	]	-RRB-
cord-321607-3r736dnk	314	36	.	.	.
cord-321607-3r736dnk	315	1	In	in	IN
cord-321607-3r736dnk	315	2	fact	fact	NN
cord-321607-3r736dnk	315	3	,	,	,
cord-321607-3r736dnk	315	4	LPS	LPS	NNP
cord-321607-3r736dnk	315	5	-	-	HYPH
cord-321607-3r736dnk	315	6	activated	activate	VBN
cord-321607-3r736dnk	315	7	,	,	,
cord-321607-3r736dnk	315	8	RIG	rig	NN
cord-321607-3r736dnk	315	9	-	-	HYPH
cord-321607-3r736dnk	315	10	I	i	NN
cord-321607-3r736dnk	315	11	-	-	HYPH
cord-321607-3r736dnk	315	12	deficient	deficient	JJ
cord-321607-3r736dnk	315	13	macrophages	macrophage	NNS
cord-321607-3r736dnk	315	14	have	have	VBP
cord-321607-3r736dnk	315	15	impaired	impair	VBN
cord-321607-3r736dnk	315	16	phagocytosis	phagocytosis	NN
cord-321607-3r736dnk	315	17	and	and	CC
cord-321607-3r736dnk	315	18	actin	actin	NN
cord-321607-3r736dnk	315	19	polymerization	polymerization	NN
cord-321607-3r736dnk	315	20	[	[	-LRB-
cord-321607-3r736dnk	315	21	138	138	CD
cord-321607-3r736dnk	315	22	]	]	-RRB-
cord-321607-3r736dnk	315	23	.	.	.
cord-321607-3r736dnk	316	1	When	when	WRB
cord-321607-3r736dnk	316	2	cells	cell	NNS
cord-321607-3r736dnk	316	3	were	be	VBD
cord-321607-3r736dnk	316	4	treated	treat	VBN
cord-321607-3r736dnk	316	5	with	with	IN
cord-321607-3r736dnk	316	6	the	the	DT
cord-321607-3r736dnk	316	7	actin	actin	NN
cord-321607-3r736dnk	316	8	depolymerizing	depolymerize	VBG
cord-321607-3r736dnk	316	9	drug	drug	NN
cord-321607-3r736dnk	316	10	cytocholasin	cytocholasin	NNP
cord-321607-3r736dnk	316	11	-	-	HYPH
cord-321607-3r736dnk	316	12	D	D	NNP
cord-321607-3r736dnk	316	13	(	(	-LRB-
cord-321607-3r736dnk	316	14	cytD	cytd	JJ
cord-321607-3r736dnk	316	15	)	)	-RRB-
cord-321607-3r736dnk	316	16	,	,	,
cord-321607-3r736dnk	316	17	RIG	rig	NN
cord-321607-3r736dnk	316	18	-	-	:
cord-321607-3r736dnk	316	19	I	-PRON-	PRP
cord-321607-3r736dnk	316	20	relocalized	relocalize	VBD
cord-321607-3r736dnk	316	21	to	to	TO
cord-321607-3r736dnk	316	22	punctate	punctate	VB
cord-321607-3r736dnk	316	23	domains	domain	NNS
cord-321607-3r736dnk	316	24	and	and	CC
cord-321607-3r736dnk	316	25	induced	induce	VBN
cord-321607-3r736dnk	316	26	both	both	DT
cord-321607-3r736dnk	316	27	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	316	28	and	and	CC
cord-321607-3r736dnk	317	1	NF	NF	NNP
cord-321607-3r736dnk	317	2	-	-	HYPH
cord-321607-3r736dnk	317	3	κB	κB	NNP
cord-321607-3r736dnk	317	4	signaling	signal	VBG
cord-321607-3r736dnk	317	5	[	[	-LRB-
cord-321607-3r736dnk	317	6	137	137	CD
cord-321607-3r736dnk	317	7	]	]	-RRB-
cord-321607-3r736dnk	317	8	.	.	.
cord-321607-3r736dnk	318	1	Although	although	IN
cord-321607-3r736dnk	318	2	the	the	DT
cord-321607-3r736dnk	318	3	use	use	NN
cord-321607-3r736dnk	318	4	of	of	IN
cord-321607-3r736dnk	318	5	cytD	cytd	NN
cord-321607-3r736dnk	318	6	may	may	MD
cord-321607-3r736dnk	318	7	mimic	mimic	VB
cord-321607-3r736dnk	318	8	the	the	DT
cord-321607-3r736dnk	318	9	actin	actin	NN
cord-321607-3r736dnk	318	10	depolymerization	depolymerization	NN
cord-321607-3r736dnk	318	11	that	that	WDT
cord-321607-3r736dnk	318	12	can	can	MD
cord-321607-3r736dnk	318	13	occur	occur	VB
cord-321607-3r736dnk	318	14	during	during	IN
cord-321607-3r736dnk	318	15	virus	virus	NN
cord-321607-3r736dnk	318	16	infection	infection	NN
cord-321607-3r736dnk	318	17	,	,	,
cord-321607-3r736dnk	318	18	cytD	cytd	JJ
cord-321607-3r736dnk	318	19	activation	activation	NN
cord-321607-3r736dnk	318	20	of	of	IN
cord-321607-3r736dnk	318	21	RIG	rig	NN
cord-321607-3r736dnk	318	22	-	-	:
cord-321607-3r736dnk	318	23	I	i	NN
cord-321607-3r736dnk	318	24	and	and	CC
cord-321607-3r736dnk	318	25	induction	induction	NN
cord-321607-3r736dnk	318	26	of	of	IN
cord-321607-3r736dnk	318	27	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	318	28	expression	expression	NN
cord-321607-3r736dnk	318	29	in	in	IN
cord-321607-3r736dnk	318	30	the	the	DT
cord-321607-3r736dnk	318	31	absence	absence	NN
cord-321607-3r736dnk	318	32	of	of	IN
cord-321607-3r736dnk	318	33	known	know	VBN
cord-321607-3r736dnk	318	34	viral	viral	JJ
cord-321607-3r736dnk	318	35	agonists	agonist	NNS
cord-321607-3r736dnk	318	36	supports	support	VBZ
cord-321607-3r736dnk	318	37	the	the	DT
cord-321607-3r736dnk	318	38	role	role	NN
cord-321607-3r736dnk	318	39	of	of	IN
cord-321607-3r736dnk	318	40	the	the	DT
cord-321607-3r736dnk	318	41	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	318	42	as	as	IN
cord-321607-3r736dnk	318	43	an	an	DT
cord-321607-3r736dnk	318	44	innate	innate	JJ
cord-321607-3r736dnk	318	45	immune	immune	JJ
cord-321607-3r736dnk	318	46	sensor	sensor	NN
cord-321607-3r736dnk	318	47	.	.	.
cord-321607-3r736dnk	319	1	MAVS	mavs	RB
cord-321607-3r736dnk	319	2	:	:	:
cord-321607-3r736dnk	320	1	A	a	DT
cord-321607-3r736dnk	320	2	second	second	JJ
cord-321607-3r736dnk	320	3	mechanism	mechanism	NN
cord-321607-3r736dnk	320	4	of	of	IN
cord-321607-3r736dnk	320	5	actin	actin	NN
cord-321607-3r736dnk	320	6	-	-	HYPH
cord-321607-3r736dnk	320	7	induced	induce	VBN
cord-321607-3r736dnk	320	8	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	320	9	involves	involve	VBZ
cord-321607-3r736dnk	320	10	the	the	DT
cord-321607-3r736dnk	320	11	interaction	interaction	NN
cord-321607-3r736dnk	320	12	of	of	IN
cord-321607-3r736dnk	320	13	MAVS	MAVS	NNPS
cord-321607-3r736dnk	320	14	(	(	-LRB-
cord-321607-3r736dnk	320	15	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	320	16	antiviral	antiviral	JJ
cord-321607-3r736dnk	320	17	signaling	signal	VBG
cord-321607-3r736dnk	320	18	protein	protein	NN
cord-321607-3r736dnk	320	19	)	)	-RRB-
cord-321607-3r736dnk	320	20	and	and	CC
cord-321607-3r736dnk	320	21	focal	focal	JJ
cord-321607-3r736dnk	320	22	adhesion	adhesion	NN
cord-321607-3r736dnk	320	23	kinase	kinase	NN
cord-321607-3r736dnk	320	24	(	(	-LRB-
cord-321607-3r736dnk	320	25	FAK	FAK	NNP
cord-321607-3r736dnk	320	26	)	)	-RRB-
cord-321607-3r736dnk	320	27	.	.	.
cord-321607-3r736dnk	321	1	MAVS	MAVS	NNP
cord-321607-3r736dnk	321	2	is	be	VBZ
cord-321607-3r736dnk	321	3	an	an	DT
cord-321607-3r736dnk	321	4	adaptor	adaptor	NN
cord-321607-3r736dnk	321	5	protein	protein	NN
cord-321607-3r736dnk	321	6	that	that	WDT
cord-321607-3r736dnk	321	7	binds	bind	VBZ
cord-321607-3r736dnk	321	8	to	to	IN
cord-321607-3r736dnk	321	9	RIG	rig	NN
cord-321607-3r736dnk	321	10	-	-	:
cord-321607-3r736dnk	321	11	I	-PRON-	PRP
cord-321607-3r736dnk	321	12	or	or	CC
cord-321607-3r736dnk	321	13	MDA-5	MDA-5	NNP
cord-321607-3r736dnk	321	14	after	after	IN
cord-321607-3r736dnk	321	15	they	-PRON-	PRP
cord-321607-3r736dnk	321	16	interact	interact	VBP
cord-321607-3r736dnk	321	17	with	with	IN
cord-321607-3r736dnk	321	18	their	-PRON-	PRP$
cord-321607-3r736dnk	321	19	corresponding	correspond	VBG
cord-321607-3r736dnk	321	20	RNA	RNA	NNP
cord-321607-3r736dnk	321	21	activators	activator	NNS
cord-321607-3r736dnk	321	22	.	.	.
cord-321607-3r736dnk	322	1	This	this	DT
cord-321607-3r736dnk	322	2	interaction	interaction	NN
cord-321607-3r736dnk	322	3	then	then	RB
cord-321607-3r736dnk	322	4	leads	lead	VBZ
cord-321607-3r736dnk	322	5	to	to	IN
cord-321607-3r736dnk	322	6	the	the	DT
cord-321607-3r736dnk	322	7	activation	activation	NN
cord-321607-3r736dnk	322	8	of	of	IN
cord-321607-3r736dnk	322	9	the	the	DT
cord-321607-3r736dnk	322	10	kinases	kinase	NNS
cord-321607-3r736dnk	322	11	TANK	tank	NN
cord-321607-3r736dnk	322	12	binding	bind	VBG
cord-321607-3r736dnk	322	13	kinase-1	kinase-1	NNP
cord-321607-3r736dnk	322	14	(	(	-LRB-
cord-321607-3r736dnk	322	15	TBK-1	TBK-1	NNP
cord-321607-3r736dnk	322	16	)	)	-RRB-
cord-321607-3r736dnk	322	17	and	and	CC
cord-321607-3r736dnk	322	18	inhibitor	inhibitor	NN
cord-321607-3r736dnk	322	19	of	of	IN
cord-321607-3r736dnk	322	20	κB	κb	CD
cord-321607-3r736dnk	322	21	kinase	kinase	NN
cord-321607-3r736dnk	322	22	-	-	HYPH
cord-321607-3r736dnk	322	23	ε	ε	NN
cord-321607-3r736dnk	322	24	(	(	-LRB-
cord-321607-3r736dnk	322	25	IKKε	IKKε	NNP
cord-321607-3r736dnk	322	26	)	)	-RRB-
cord-321607-3r736dnk	322	27	,	,	,
cord-321607-3r736dnk	322	28	which	which	WDT
cord-321607-3r736dnk	322	29	phosphorylate	phosphorylate	VBP
cord-321607-3r736dnk	322	30	IRF3	IRF3	NNP
cord-321607-3r736dnk	322	31	and	and	CC
cord-321607-3r736dnk	322	32	induce	induce	VB
cord-321607-3r736dnk	322	33	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	322	34	expression	expression	NN
cord-321607-3r736dnk	322	35	.	.	.
cord-321607-3r736dnk	323	1	As	as	IN
cord-321607-3r736dnk	323	2	its	-PRON-	PRP$
cord-321607-3r736dnk	323	3	name	name	NN
cord-321607-3r736dnk	323	4	denotes	denote	VBZ
cord-321607-3r736dnk	323	5	,	,	,
cord-321607-3r736dnk	323	6	FAK	FAK	NNP
cord-321607-3r736dnk	323	7	is	be	VBZ
cord-321607-3r736dnk	323	8	a	a	DT
cord-321607-3r736dnk	323	9	protein	protein	NN
cord-321607-3r736dnk	323	10	tyrosine	tyrosine	NN
cord-321607-3r736dnk	323	11	kinase	kinase	NNS
cord-321607-3r736dnk	323	12	localized	localize	VBN
cord-321607-3r736dnk	323	13	to	to	IN
cord-321607-3r736dnk	323	14	focal	focal	JJ
cord-321607-3r736dnk	323	15	adhesion	adhesion	NN
cord-321607-3r736dnk	323	16	(	(	-LRB-
cord-321607-3r736dnk	323	17	FA	fa	NN
cord-321607-3r736dnk	323	18	)	)	-RRB-
cord-321607-3r736dnk	323	19	contacts	contact	NNS
cord-321607-3r736dnk	323	20	with	with	IN
cord-321607-3r736dnk	323	21	the	the	DT
cord-321607-3r736dnk	323	22	extracellular	extracellular	JJ
cord-321607-3r736dnk	323	23	matrix	matrix	NN
cord-321607-3r736dnk	323	24	(	(	-LRB-
cord-321607-3r736dnk	323	25	ECM	ECM	NNP
cord-321607-3r736dnk	323	26	)	)	-RRB-
cord-321607-3r736dnk	323	27	.	.	.
cord-321607-3r736dnk	324	1	The	the	DT
cord-321607-3r736dnk	324	2	FAs	fa	NNS
cord-321607-3r736dnk	324	3	relay	relay	NN
cord-321607-3r736dnk	324	4	signals	signal	NNS
cord-321607-3r736dnk	324	5	from	from	IN
cord-321607-3r736dnk	324	6	the	the	DT
cord-321607-3r736dnk	324	7	ECM	ECM	NNP
cord-321607-3r736dnk	324	8	to	to	IN
cord-321607-3r736dnk	324	9	the	the	DT
cord-321607-3r736dnk	324	10	cytoplasm	cytoplasm	NN
cord-321607-3r736dnk	324	11	and	and	CC
cord-321607-3r736dnk	324	12	are	be	VBP
cord-321607-3r736dnk	324	13	therefore	therefore	RB
cord-321607-3r736dnk	324	14	extremely	extremely	RB
cord-321607-3r736dnk	324	15	sensitive	sensitive	JJ
cord-321607-3r736dnk	324	16	to	to	IN
cord-321607-3r736dnk	324	17	activation	activation	NN
cord-321607-3r736dnk	324	18	by	by	IN
cord-321607-3r736dnk	324	19	alterations	alteration	NNS
cord-321607-3r736dnk	324	20	in	in	IN
cord-321607-3r736dnk	324	21	the	the	DT
cord-321607-3r736dnk	324	22	actin	actin	NN
cord-321607-3r736dnk	324	23	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	324	24	.	.	.
cord-321607-3r736dnk	325	1	As	as	IN
cord-321607-3r736dnk	325	2	a	a	DT
cord-321607-3r736dnk	325	3	result	result	NN
cord-321607-3r736dnk	325	4	,	,	,
cord-321607-3r736dnk	325	5	virus	virus	NN
cord-321607-3r736dnk	325	6	infection	infection	NN
cord-321607-3r736dnk	325	7	was	be	VBD
cord-321607-3r736dnk	325	8	shown	show	VBN
cord-321607-3r736dnk	325	9	to	to	TO
cord-321607-3r736dnk	325	10	relocate	relocate	VB
cord-321607-3r736dnk	325	11	FAK	FAK	NNP
cord-321607-3r736dnk	325	12	from	from	IN
cord-321607-3r736dnk	325	13	FAs	fa	NNS
cord-321607-3r736dnk	325	14	to	to	IN
cord-321607-3r736dnk	325	15	the	the	DT
cord-321607-3r736dnk	325	16	mitochondrion	mitochondrion	NN
cord-321607-3r736dnk	325	17	where	where	WRB
cord-321607-3r736dnk	325	18	it	-PRON-	PRP
cord-321607-3r736dnk	325	19	binds	bind	VBZ
cord-321607-3r736dnk	325	20	to	to	IN
cord-321607-3r736dnk	325	21	MAVS	MAVS	NNP
cord-321607-3r736dnk	325	22	to	to	TO
cord-321607-3r736dnk	325	23	induce	induce	VB
cord-321607-3r736dnk	325	24	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	325	25	.	.	.
cord-321607-3r736dnk	326	1	FAK	FAK	NNP
cord-321607-3r736dnk	326	2	-	-	HYPH
cord-321607-3r736dnk	326	3	deficient	deficient	JJ
cord-321607-3r736dnk	326	4	cells	cell	NNS
cord-321607-3r736dnk	326	5	are	be	VBP
cord-321607-3r736dnk	326	6	defective	defective	JJ
cord-321607-3r736dnk	326	7	in	in	IN
cord-321607-3r736dnk	326	8	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	326	9	expression	expression	NN
cord-321607-3r736dnk	326	10	and	and	CC
cord-321607-3r736dnk	326	11	more	more	RBR
cord-321607-3r736dnk	326	12	susceptible	susceptible	JJ
cord-321607-3r736dnk	326	13	to	to	IN
cord-321607-3r736dnk	326	14	virus	virus	NN
cord-321607-3r736dnk	326	15	infections	infection	NNS
cord-321607-3r736dnk	326	16	,	,	,
cord-321607-3r736dnk	326	17	indicating	indicate	VBG
cord-321607-3r736dnk	326	18	that	that	IN
cord-321607-3r736dnk	326	19	FAK	FAK	NNP
cord-321607-3r736dnk	326	20	may	may	MD
cord-321607-3r736dnk	326	21	serve	serve	VB
cord-321607-3r736dnk	326	22	as	as	IN
cord-321607-3r736dnk	326	23	an	an	DT
cord-321607-3r736dnk	326	24	important	important	JJ
cord-321607-3r736dnk	326	25	link	link	NN
cord-321607-3r736dnk	326	26	between	between	IN
cord-321607-3r736dnk	326	27	virus	virus	NN
cord-321607-3r736dnk	326	28	-	-	HYPH
cord-321607-3r736dnk	326	29	induced	induce	VBN
cord-321607-3r736dnk	326	30	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	326	31	disruption	disruption	NN
cord-321607-3r736dnk	326	32	and	and	CC
cord-321607-3r736dnk	326	33	IRF3	IRF3	NNP
cord-321607-3r736dnk	326	34	signaling	signal	VBG
cord-321607-3r736dnk	326	35	[	[	-LRB-
cord-321607-3r736dnk	326	36	139	139	CD
cord-321607-3r736dnk	326	37	]	]	-RRB-
cord-321607-3r736dnk	326	38	.	.	.
cord-321607-3r736dnk	327	1	TBK1	TBK1	NNP
cord-321607-3r736dnk	327	2	:	:	:
cord-321607-3r736dnk	328	1	GEF	GEF	NNP
cord-321607-3r736dnk	328	2	-	-	HYPH
cord-321607-3r736dnk	328	3	H1	H1	NNP
cord-321607-3r736dnk	328	4	is	be	VBZ
cord-321607-3r736dnk	328	5	a	a	DT
cord-321607-3r736dnk	328	6	RhoA	RhoA	NNP
cord-321607-3r736dnk	328	7	guanine	guanine	NN
cord-321607-3r736dnk	328	8	nucleotide	nucleotide	JJ
cord-321607-3r736dnk	328	9	exchange	exchange	NN
cord-321607-3r736dnk	328	10	factor	factor	NN
cord-321607-3r736dnk	328	11	that	that	WDT
cord-321607-3r736dnk	328	12	binds	bind	VBZ
cord-321607-3r736dnk	328	13	to	to	IN
cord-321607-3r736dnk	328	14	the	the	DT
cord-321607-3r736dnk	328	15	dynein	dynein	JJ
cord-321607-3r736dnk	328	16	motor	motor	NN
cord-321607-3r736dnk	328	17	complex	complex	NN
cord-321607-3r736dnk	328	18	on	on	IN
cord-321607-3r736dnk	328	19	microtubules	microtubule	NNS
cord-321607-3r736dnk	328	20	.	.	.
cord-321607-3r736dnk	329	1	Past	past	NN
cord-321607-3r736dnk	329	2	work	work	NN
cord-321607-3r736dnk	329	3	demonstrated	demonstrate	VBD
cord-321607-3r736dnk	329	4	that	that	IN
cord-321607-3r736dnk	329	5	it	-PRON-	PRP
cord-321607-3r736dnk	329	6	activates	activate	VBZ
cord-321607-3r736dnk	329	7	NOD1	NOD1	NNP
cord-321607-3r736dnk	329	8	,	,	,
cord-321607-3r736dnk	329	9	NOD2	NOD2	NNPS
cord-321607-3r736dnk	329	10	,	,	,
cord-321607-3r736dnk	329	11	and	and	CC
cord-321607-3r736dnk	329	12	phosphorylates	phosphorylate	VBZ
cord-321607-3r736dnk	329	13	Rip2	Rip2	NNP
cord-321607-3r736dnk	329	14	in	in	IN
cord-321607-3r736dnk	329	15	response	response	NN
cord-321607-3r736dnk	329	16	to	to	IN
cord-321607-3r736dnk	329	17	bacterial	bacterial	JJ
cord-321607-3r736dnk	329	18	infection	infection	NN
cord-321607-3r736dnk	329	19	[	[	-LRB-
cord-321607-3r736dnk	329	20	147	147	CD
cord-321607-3r736dnk	329	21	,	,	,
cord-321607-3r736dnk	329	22	148	148	CD
cord-321607-3r736dnk	329	23	]	]	-RRB-
cord-321607-3r736dnk	329	24	.	.	.
cord-321607-3r736dnk	330	1	Recently	recently	RB
cord-321607-3r736dnk	330	2	,	,	,
cord-321607-3r736dnk	330	3	it	-PRON-	PRP
cord-321607-3r736dnk	330	4	has	have	VBZ
cord-321607-3r736dnk	330	5	also	also	RB
cord-321607-3r736dnk	330	6	been	be	VBN
cord-321607-3r736dnk	330	7	shown	show	VBN
cord-321607-3r736dnk	330	8	to	to	TO
cord-321607-3r736dnk	330	9	be	be	VB
cord-321607-3r736dnk	330	10	critical	critical	JJ
cord-321607-3r736dnk	330	11	for	for	IN
cord-321607-3r736dnk	330	12	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	330	13	expression	expression	NN
cord-321607-3r736dnk	330	14	in	in	IN
cord-321607-3r736dnk	330	15	response	response	NN
cord-321607-3r736dnk	330	16	to	to	IN
cord-321607-3r736dnk	330	17	nucleic	nucleic	JJ
cord-321607-3r736dnk	330	18	acid	acid	NN
cord-321607-3r736dnk	330	19	PAMPs	pamp	NNS
cord-321607-3r736dnk	330	20	.	.	.
cord-321607-3r736dnk	331	1	Upon	upon	IN
cord-321607-3r736dnk	331	2	activation	activation	NN
cord-321607-3r736dnk	331	3	of	of	IN
cord-321607-3r736dnk	331	4	RLRs	rlr	NNS
cord-321607-3r736dnk	331	5	,	,	,
cord-321607-3r736dnk	331	6	GEF	GEF	NNP
cord-321607-3r736dnk	331	7	-	-	HYPH
cord-321607-3r736dnk	331	8	H1	H1	NNP
cord-321607-3r736dnk	331	9	is	be	VBZ
cord-321607-3r736dnk	331	10	dephosphorylated	dephosphorylate	VBN
cord-321607-3r736dnk	331	11	and	and	CC
cord-321607-3r736dnk	331	12	released	release	VBN
cord-321607-3r736dnk	331	13	from	from	IN
cord-321607-3r736dnk	331	14	microtubules	microtubule	NNS
cord-321607-3r736dnk	331	15	,	,	,
cord-321607-3r736dnk	331	16	freeing	free	VBG
cord-321607-3r736dnk	331	17	it	-PRON-	PRP
cord-321607-3r736dnk	331	18	to	to	TO
cord-321607-3r736dnk	331	19	bind	bind	VB
cord-321607-3r736dnk	331	20	to	to	IN
cord-321607-3r736dnk	331	21	TBK1	TBK1	NNP
cord-321607-3r736dnk	331	22	and	and	CC
cord-321607-3r736dnk	331	23	thus	thus	RB
cord-321607-3r736dnk	331	24	activating	activate	VBG
cord-321607-3r736dnk	331	25	IRF3	IRF3	NNP
cord-321607-3r736dnk	331	26	to	to	TO
cord-321607-3r736dnk	331	27	express	express	VB
cord-321607-3r736dnk	331	28	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	331	29	.	.	.
cord-321607-3r736dnk	332	1	This	this	DT
cord-321607-3r736dnk	332	2	interaction	interaction	NN
cord-321607-3r736dnk	332	3	between	between	IN
cord-321607-3r736dnk	332	4	GEF	GEF	NNP
cord-321607-3r736dnk	332	5	-	-	HYPH
cord-321607-3r736dnk	332	6	H1	H1	NNP
cord-321607-3r736dnk	332	7	and	and	CC
cord-321607-3r736dnk	332	8	TBK1	TBK1	NNP
cord-321607-3r736dnk	332	9	is	be	VBZ
cord-321607-3r736dnk	332	10	dependent	dependent	JJ
cord-321607-3r736dnk	332	11	on	on	IN
cord-321607-3r736dnk	332	12	functional	functional	JJ
cord-321607-3r736dnk	332	13	microtubules	microtubule	NNS
cord-321607-3r736dnk	332	14	.	.	.
cord-321607-3r736dnk	333	1	For	for	IN
cord-321607-3r736dnk	333	2	undetermined	undetermined	JJ
cord-321607-3r736dnk	333	3	reasons	reason	NNS
cord-321607-3r736dnk	333	4	,	,	,
cord-321607-3r736dnk	333	5	this	this	DT
cord-321607-3r736dnk	333	6	regulation	regulation	NN
cord-321607-3r736dnk	333	7	is	be	VBZ
cord-321607-3r736dnk	333	8	only	only	RB
cord-321607-3r736dnk	333	9	seen	see	VBN
cord-321607-3r736dnk	333	10	in	in	IN
cord-321607-3r736dnk	333	11	response	response	NN
cord-321607-3r736dnk	333	12	to	to	IN
cord-321607-3r736dnk	333	13	RIG	rig	NN
cord-321607-3r736dnk	333	14	-	-	:
cord-321607-3r736dnk	333	15	I	I	NNP
cord-321607-3r736dnk	333	16	,	,	,
cord-321607-3r736dnk	333	17	MDA-5	MDA-5	NNP
cord-321607-3r736dnk	333	18	,	,	,
cord-321607-3r736dnk	333	19	and	and	CC
cord-321607-3r736dnk	333	20	STING	sting	NN
cord-321607-3r736dnk	333	21	,	,	,
cord-321607-3r736dnk	333	22	but	but	CC
cord-321607-3r736dnk	333	23	not	not	RB
cord-321607-3r736dnk	333	24	TLR	TLR	NNP
cord-321607-3r736dnk	333	25	activation	activation	NN
cord-321607-3r736dnk	333	26	[	[	-LRB-
cord-321607-3r736dnk	333	27	140	140	CD
cord-321607-3r736dnk	333	28	]	]	-RRB-
cord-321607-3r736dnk	333	29	.	.	.
cord-321607-3r736dnk	334	1	NOD2	NOD2	NNS
cord-321607-3r736dnk	334	2	:	:	:
cord-321607-3r736dnk	335	1	NOD2	NOD2	NNS
cord-321607-3r736dnk	335	2	can	can	MD
cord-321607-3r736dnk	335	3	be	be	VB
cord-321607-3r736dnk	335	4	activated	activate	VBN
cord-321607-3r736dnk	335	5	by	by	IN
cord-321607-3r736dnk	335	6	bacterial	bacterial	JJ
cord-321607-3r736dnk	335	7	PAMPs	pamp	NNS
cord-321607-3r736dnk	335	8	as	as	RB
cord-321607-3r736dnk	335	9	well	well	RB
cord-321607-3r736dnk	335	10	as	as	IN
cord-321607-3r736dnk	335	11	viral	viral	JJ
cord-321607-3r736dnk	335	12	ssRNA	ssRNA	''
cord-321607-3r736dnk	335	13	to	to	TO
cord-321607-3r736dnk	335	14	induce	induce	VB
cord-321607-3r736dnk	335	15	NF	nf	NN
cord-321607-3r736dnk	335	16	-	-	HYPH
cord-321607-3r736dnk	335	17	κB	κB	NNP
cord-321607-3r736dnk	335	18	and	and	CC
cord-321607-3r736dnk	335	19	IRF3	IRF3	NNP
cord-321607-3r736dnk	335	20	signaling	signal	VBG
cord-321607-3r736dnk	335	21	[	[	-LRB-
cord-321607-3r736dnk	335	22	108	108	CD
cord-321607-3r736dnk	335	23	]	]	-RRB-
cord-321607-3r736dnk	335	24	.	.	.
cord-321607-3r736dnk	336	1	Legrand	Legrand	NNP
cord-321607-3r736dnk	336	2	-	-	HYPH
cord-321607-3r736dnk	336	3	Poels	Poels	NNP
cord-321607-3r736dnk	336	4	et	et	NNP
cord-321607-3r736dnk	336	5	al	al	NNP
cord-321607-3r736dnk	336	6	.	.	.
cord-321607-3r736dnk	337	1	[	[	-LRB-
cord-321607-3r736dnk	337	2	136	136	CD
cord-321607-3r736dnk	337	3	]	]	-RRB-
cord-321607-3r736dnk	337	4	,	,	,
cord-321607-3r736dnk	337	5	have	have	VBP
cord-321607-3r736dnk	337	6	shown	show	VBN
cord-321607-3r736dnk	337	7	that	that	IN
cord-321607-3r736dnk	337	8	NOD2	NOD2	NNP
cord-321607-3r736dnk	337	9	binds	bind	VBZ
cord-321607-3r736dnk	337	10	to	to	IN
cord-321607-3r736dnk	337	11	Rac1	Rac1	NNP
cord-321607-3r736dnk	337	12	,	,	,
cord-321607-3r736dnk	337	13	a	a	DT
cord-321607-3r736dnk	337	14	GTP	gtp	NN
cord-321607-3r736dnk	337	15	-	-	HYPH
cord-321607-3r736dnk	337	16	binding	bind	VBG
cord-321607-3r736dnk	337	17	Rho	Rho	NNP
cord-321607-3r736dnk	337	18	family	family	NN
cord-321607-3r736dnk	337	19	member	member	NN
cord-321607-3r736dnk	337	20	that	that	WDT
cord-321607-3r736dnk	337	21	regulates	regulate	VBZ
cord-321607-3r736dnk	337	22	actin	actin	NN
cord-321607-3r736dnk	337	23	polymerization	polymerization	NN
cord-321607-3r736dnk	337	24	,	,	,
cord-321607-3r736dnk	337	25	and	and	CC
cord-321607-3r736dnk	337	26	recruits	recruit	VBZ
cord-321607-3r736dnk	337	27	it	-PRON-	PRP
cord-321607-3r736dnk	337	28	to	to	IN
cord-321607-3r736dnk	337	29	actin	actin	NN
cord-321607-3r736dnk	337	30	-	-	HYPH
cord-321607-3r736dnk	337	31	rich	rich	JJ
cord-321607-3r736dnk	337	32	membrane	membrane	NN
cord-321607-3r736dnk	337	33	ruffles	ruffle	NNS
cord-321607-3r736dnk	337	34	.	.	.
cord-321607-3r736dnk	338	1	There	there	RB
cord-321607-3r736dnk	338	2	it	-PRON-	PRP
cord-321607-3r736dnk	338	3	is	be	VBZ
cord-321607-3r736dnk	338	4	sequestered	sequester	VBN
cord-321607-3r736dnk	338	5	in	in	IN
cord-321607-3r736dnk	338	6	a	a	DT
cord-321607-3r736dnk	338	7	latent	latent	JJ
cord-321607-3r736dnk	338	8	state	state	NN
cord-321607-3r736dnk	338	9	until	until	IN
cord-321607-3r736dnk	338	10	actin	actin	NN
cord-321607-3r736dnk	338	11	disruption	disruption	NN
cord-321607-3r736dnk	338	12	,	,	,
cord-321607-3r736dnk	338	13	potentially	potentially	RB
cord-321607-3r736dnk	338	14	by	by	IN
cord-321607-3r736dnk	338	15	infection	infection	NN
cord-321607-3r736dnk	338	16	,	,	,
cord-321607-3r736dnk	338	17	releases	release	VBZ
cord-321607-3r736dnk	338	18	it	-PRON-	PRP
cord-321607-3r736dnk	338	19	to	to	TO
cord-321607-3r736dnk	338	20	begin	begin	VB
cord-321607-3r736dnk	338	21	signaling	signal	VBG
cord-321607-3r736dnk	338	22	.	.	.
cord-321607-3r736dnk	339	1	Treatment	treatment	NN
cord-321607-3r736dnk	339	2	of	of	IN
cord-321607-3r736dnk	339	3	cells	cell	NNS
cord-321607-3r736dnk	339	4	with	with	IN
cord-321607-3r736dnk	339	5	cytD	cytd	JJ
cord-321607-3r736dnk	339	6	or	or	CC
cord-321607-3r736dnk	339	7	the	the	DT
cord-321607-3r736dnk	339	8	actin	actin	NN
cord-321607-3r736dnk	339	9	polymerization	polymerization	NN
cord-321607-3r736dnk	339	10	inhibitor	inhibitor	NN
cord-321607-3r736dnk	339	11	latrunculin	latrunculin	NN
cord-321607-3r736dnk	339	12	B	B	NNP
cord-321607-3r736dnk	339	13	significantly	significantly	RB
cord-321607-3r736dnk	339	14	increased	increase	VBD
cord-321607-3r736dnk	340	1	NF	NF	NNP
cord-321607-3r736dnk	340	2	-	-	HYPH
cord-321607-3r736dnk	340	3	κB	κB	NNP
cord-321607-3r736dnk	340	4	signaling	signal	VBG
cord-321607-3r736dnk	340	5	and	and	CC
cord-321607-3r736dnk	340	6	caused	cause	VBD
cord-321607-3r736dnk	340	7	NOD2	NOD2	NNP
cord-321607-3r736dnk	340	8	to	to	TO
cord-321607-3r736dnk	340	9	shift	shift	VB
cord-321607-3r736dnk	340	10	from	from	IN
cord-321607-3r736dnk	340	11	the	the	DT
cord-321607-3r736dnk	340	12	insoluble	insoluble	JJ
cord-321607-3r736dnk	340	13	Triton	Triton	NNP
cord-321607-3r736dnk	340	14	-	-	HYPH
cord-321607-3r736dnk	340	15	X-100	x-100	NN
cord-321607-3r736dnk	340	16	cell	cell	NN
cord-321607-3r736dnk	340	17	fraction	fraction	NN
cord-321607-3r736dnk	340	18	to	to	IN
cord-321607-3r736dnk	340	19	the	the	DT
cord-321607-3r736dnk	340	20	soluble	soluble	JJ
cord-321607-3r736dnk	340	21	fraction	fraction	NN
cord-321607-3r736dnk	340	22	.	.	.
cord-321607-3r736dnk	341	1	As	as	IN
cord-321607-3r736dnk	341	2	previously	previously	RB
cord-321607-3r736dnk	341	3	described	describe	VBN
cord-321607-3r736dnk	341	4	,	,	,
cord-321607-3r736dnk	341	5	OAS	OAS	NNP
cord-321607-3r736dnk	341	6	also	also	RB
cord-321607-3r736dnk	341	7	binds	bind	VBZ
cord-321607-3r736dnk	341	8	to	to	IN
cord-321607-3r736dnk	341	9	NOD2	NOD2	NNP
cord-321607-3r736dnk	341	10	,	,	,
cord-321607-3r736dnk	341	11	which	which	WDT
cord-321607-3r736dnk	341	12	could	could	MD
cord-321607-3r736dnk	341	13	potentially	potentially	RB
cord-321607-3r736dnk	341	14	localize	localize	VB
cord-321607-3r736dnk	341	15	it	-PRON-	PRP
cord-321607-3r736dnk	341	16	to	to	IN
cord-321607-3r736dnk	341	17	the	the	DT
cord-321607-3r736dnk	341	18	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	341	19	as	as	RB
cord-321607-3r736dnk	341	20	well	well	RB
cord-321607-3r736dnk	341	21	.	.	.
cord-321607-3r736dnk	342	1	This	this	DT
cord-321607-3r736dnk	342	2	would	would	MD
cord-321607-3r736dnk	342	3	place	place	VB
cord-321607-3r736dnk	342	4	it	-PRON-	PRP
cord-321607-3r736dnk	342	5	in	in	IN
cord-321607-3r736dnk	342	6	proximity	proximity	NN
cord-321607-3r736dnk	342	7	to	to	IN
cord-321607-3r736dnk	342	8	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	342	9	-	-	HYPH
cord-321607-3r736dnk	342	10	associated	associate	VBN
cord-321607-3r736dnk	342	11	RNase	RNase	NNP
cord-321607-3r736dnk	342	12	-	-	HYPH
cord-321607-3r736dnk	342	13	L	l	NN
cord-321607-3r736dnk	342	14	for	for	IN
cord-321607-3r736dnk	342	15	rapid	rapid	JJ
cord-321607-3r736dnk	342	16	,	,	,
cord-321607-3r736dnk	342	17	and	and	CC
cord-321607-3r736dnk	342	18	perhaps	perhaps	RB
cord-321607-3r736dnk	342	19	localized	localize	VBN
cord-321607-3r736dnk	342	20	,	,	,
cord-321607-3r736dnk	342	21	activation	activation	NN
cord-321607-3r736dnk	342	22	.	.	.
cord-321607-3r736dnk	343	1	In	in	IN
cord-321607-3r736dnk	343	2	addition	addition	NN
cord-321607-3r736dnk	343	3	,	,	,
cord-321607-3r736dnk	343	4	the	the	DT
cord-321607-3r736dnk	343	5	presence	presence	NN
cord-321607-3r736dnk	343	6	of	of	IN
cord-321607-3r736dnk	343	7	NOD2	NOD2	NNP
cord-321607-3r736dnk	343	8	was	be	VBD
cord-321607-3r736dnk	343	9	shown	show	VBN
cord-321607-3r736dnk	343	10	to	to	TO
cord-321607-3r736dnk	343	11	enhance	enhance	VB
cord-321607-3r736dnk	343	12	RNase	RNase	NNP
cord-321607-3r736dnk	343	13	-	-	HYPH
cord-321607-3r736dnk	343	14	L	l	NN
cord-321607-3r736dnk	343	15	activation	activation	NN
cord-321607-3r736dnk	343	16	in	in	IN
cord-321607-3r736dnk	343	17	response	response	NN
cord-321607-3r736dnk	343	18	to	to	IN
cord-321607-3r736dnk	343	19	dsRNA	dsrna	NN
cord-321607-3r736dnk	343	20	,	,	,
cord-321607-3r736dnk	343	21	possibly	possibly	RB
cord-321607-3r736dnk	343	22	generating	generate	VBG
cord-321607-3r736dnk	343	23	a	a	DT
cord-321607-3r736dnk	343	24	more	more	RBR
cord-321607-3r736dnk	343	25	robust	robust	JJ
cord-321607-3r736dnk	343	26	response	response	NN
cord-321607-3r736dnk	343	27	to	to	IN
cord-321607-3r736dnk	343	28	viral	viral	JJ
cord-321607-3r736dnk	343	29	infection	infection	NN
cord-321607-3r736dnk	343	30	[	[	-LRB-
cord-321607-3r736dnk	343	31	109	109	CD
cord-321607-3r736dnk	343	32	]	]	-RRB-
cord-321607-3r736dnk	343	33	.	.	.
cord-321607-3r736dnk	344	1	ASC	ASC	NNP
cord-321607-3r736dnk	344	2	:	:	:
cord-321607-3r736dnk	345	1	Inflammasome	Inflammasome	NNP
cord-321607-3r736dnk	345	2	activation	activation	NN
cord-321607-3r736dnk	345	3	is	be	VBZ
cord-321607-3r736dnk	345	4	induced	induce	VBN
cord-321607-3r736dnk	345	5	by	by	IN
cord-321607-3r736dnk	345	6	either	either	CC
cord-321607-3r736dnk	345	7	PAMPS	PAMPS	NNP
cord-321607-3r736dnk	345	8	or	or	CC
cord-321607-3r736dnk	345	9	DAMPS	damp	NNS
cord-321607-3r736dnk	345	10	which	which	WDT
cord-321607-3r736dnk	345	11	typically	typically	RB
cord-321607-3r736dnk	345	12	stimulate	stimulate	VBP
cord-321607-3r736dnk	345	13	the	the	DT
cord-321607-3r736dnk	345	14	oligomerization	oligomerization	NN
cord-321607-3r736dnk	345	15	of	of	IN
cord-321607-3r736dnk	345	16	one	one	CD
cord-321607-3r736dnk	345	17	of	of	IN
cord-321607-3r736dnk	345	18	the	the	DT
cord-321607-3r736dnk	345	19	NLRs	nlr	NNS
cord-321607-3r736dnk	345	20	,	,	,
cord-321607-3r736dnk	345	21	ASC	ASC	NNP
cord-321607-3r736dnk	345	22	(	(	-LRB-
cord-321607-3r736dnk	345	23	apoptosis	apoptosis	NN
cord-321607-3r736dnk	345	24	-	-	HYPH
cord-321607-3r736dnk	345	25	associated	associate	VBN
cord-321607-3r736dnk	345	26	speck	speck	NN
cord-321607-3r736dnk	345	27	-	-	HYPH
cord-321607-3r736dnk	345	28	like	like	JJ
cord-321607-3r736dnk	345	29	protein	protein	NN
cord-321607-3r736dnk	345	30	containing	contain	VBG
cord-321607-3r736dnk	345	31	CARD	card	NN
cord-321607-3r736dnk	345	32	;	;	:
cord-321607-3r736dnk	345	33	caspase	caspase	NN
cord-321607-3r736dnk	345	34	recruitment	recruitment	NN
cord-321607-3r736dnk	345	35	domain	domain	NN
cord-321607-3r736dnk	345	36	)	)	-RRB-
cord-321607-3r736dnk	345	37	,	,	,
cord-321607-3r736dnk	345	38	and	and	CC
cord-321607-3r736dnk	345	39	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	345	40	.	.	.
cord-321607-3r736dnk	346	1	This	this	DT
cord-321607-3r736dnk	346	2	leads	lead	VBZ
cord-321607-3r736dnk	346	3	to	to	IN
cord-321607-3r736dnk	346	4	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	346	5	activation	activation	NN
cord-321607-3r736dnk	346	6	,	,	,
cord-321607-3r736dnk	346	7	enabling	enable	VBG
cord-321607-3r736dnk	346	8	it	-PRON-	PRP
cord-321607-3r736dnk	346	9	to	to	TO
cord-321607-3r736dnk	346	10	cleave	cleave	VB
cord-321607-3r736dnk	346	11	IL-1β	IL-1β	NNP
cord-321607-3r736dnk	346	12	and	and	CC
cord-321607-3r736dnk	346	13	IL-18	IL-18	NNP
cord-321607-3r736dnk	346	14	into	into	IN
cord-321607-3r736dnk	346	15	their	-PRON-	PRP$
cord-321607-3r736dnk	346	16	mature	mature	JJ
cord-321607-3r736dnk	346	17	forms	form	NNS
cord-321607-3r736dnk	346	18	[	[	-LRB-
cord-321607-3r736dnk	346	19	108	108	CD
cord-321607-3r736dnk	346	20	]	]	-RRB-
cord-321607-3r736dnk	346	21	.	.	.
cord-321607-3r736dnk	347	1	ASC	ASC	NNP
cord-321607-3r736dnk	347	2	KO	KO	NNP
cord-321607-3r736dnk	347	3	cells	cell	NNS
cord-321607-3r736dnk	347	4	have	have	VBP
cord-321607-3r736dnk	347	5	been	be	VBN
cord-321607-3r736dnk	347	6	shown	show	VBN
cord-321607-3r736dnk	347	7	to	to	TO
cord-321607-3r736dnk	347	8	be	be	VB
cord-321607-3r736dnk	347	9	deficient	deficient	JJ
cord-321607-3r736dnk	347	10	in	in	IN
cord-321607-3r736dnk	347	11	antigen	antigen	NN
cord-321607-3r736dnk	347	12	uptake	uptake	NN
cord-321607-3r736dnk	347	13	and	and	CC
cord-321607-3r736dnk	347	14	presentation	presentation	NN
cord-321607-3r736dnk	347	15	,	,	,
cord-321607-3r736dnk	347	16	independent	independent	JJ
cord-321607-3r736dnk	347	17	of	of	IN
cord-321607-3r736dnk	347	18	its	-PRON-	PRP$
cord-321607-3r736dnk	347	19	inflammasome	inflammasome	NN
cord-321607-3r736dnk	347	20	activity	activity	NN
cord-321607-3r736dnk	347	21	.	.	.
cord-321607-3r736dnk	348	1	Gene	gene	NN
cord-321607-3r736dnk	348	2	expression	expression	NN
cord-321607-3r736dnk	348	3	comparisons	comparison	NNS
cord-321607-3r736dnk	348	4	between	between	IN
cord-321607-3r736dnk	348	5	WT	WT	NNP
cord-321607-3r736dnk	348	6	and	and	CC
cord-321607-3r736dnk	348	7	ASC	ASC	NNP
cord-321607-3r736dnk	348	8	KO	KO	NNP
cord-321607-3r736dnk	348	9	cells	cell	NNS
cord-321607-3r736dnk	348	10	identified	identify	VBD
cord-321607-3r736dnk	348	11	a	a	DT
cord-321607-3r736dnk	348	12	novel	novel	JJ
cord-321607-3r736dnk	348	13	role	role	NN
cord-321607-3r736dnk	348	14	for	for	IN
cord-321607-3r736dnk	348	15	ASC	ASC	NNP
cord-321607-3r736dnk	348	16	in	in	IN
cord-321607-3r736dnk	348	17	the	the	DT
cord-321607-3r736dnk	348	18	stabilization	stabilization	NN
cord-321607-3r736dnk	348	19	of	of	IN
cord-321607-3r736dnk	348	20	Dock2	Dock2	NNP
cord-321607-3r736dnk	348	21	mRNA	mRNA	NNP
cord-321607-3r736dnk	348	22	.	.	.
cord-321607-3r736dnk	349	1	Dock2	Dock2	NNP
cord-321607-3r736dnk	349	2	is	be	VBZ
cord-321607-3r736dnk	349	3	a	a	DT
cord-321607-3r736dnk	349	4	guanine	guanine	NN
cord-321607-3r736dnk	349	5	nucleotide	nucleotide	JJ
cord-321607-3r736dnk	349	6	exchange	exchange	NN
cord-321607-3r736dnk	349	7	factor	factor	NN
cord-321607-3r736dnk	349	8	that	that	WDT
cord-321607-3r736dnk	349	9	mediates	mediate	VBZ
cord-321607-3r736dnk	349	10	Rac	Rac	NNP
cord-321607-3r736dnk	349	11	-	-	HYPH
cord-321607-3r736dnk	349	12	dependent	dependent	JJ
cord-321607-3r736dnk	349	13	actin	actin	NN
cord-321607-3r736dnk	349	14	polymerization	polymerization	NN
cord-321607-3r736dnk	349	15	;	;	:
cord-321607-3r736dnk	349	16	thus	thus	RB
cord-321607-3r736dnk	349	17	,	,	,
cord-321607-3r736dnk	349	18	in	in	IN
cord-321607-3r736dnk	349	19	the	the	DT
cord-321607-3r736dnk	349	20	absence	absence	NN
cord-321607-3r736dnk	349	21	of	of	IN
cord-321607-3r736dnk	349	22	ASC	ASC	NNP
cord-321607-3r736dnk	349	23	,	,	,
cord-321607-3r736dnk	349	24	Dock2	dock2	JJ
cord-321607-3r736dnk	349	25	levels	level	NNS
cord-321607-3r736dnk	349	26	are	be	VBP
cord-321607-3r736dnk	349	27	low	low	JJ
cord-321607-3r736dnk	349	28	,	,	,
cord-321607-3r736dnk	349	29	resulting	result	VBG
cord-321607-3r736dnk	349	30	in	in	IN
cord-321607-3r736dnk	349	31	inactive	inactive	JJ
cord-321607-3r736dnk	349	32	Rac	Rac	NNP
cord-321607-3r736dnk	349	33	and	and	CC
cord-321607-3r736dnk	349	34	deficient	deficient	JJ
cord-321607-3r736dnk	349	35	filamentous	filamentous	JJ
cord-321607-3r736dnk	349	36	actin	actin	NN
cord-321607-3r736dnk	349	37	production	production	NN
cord-321607-3r736dnk	349	38	[	[	-LRB-
cord-321607-3r736dnk	349	39	142	142	CD
cord-321607-3r736dnk	349	40	]	]	-RRB-
cord-321607-3r736dnk	349	41	.	.	.
cord-321607-3r736dnk	350	1	This	this	DT
cord-321607-3r736dnk	350	2	inability	inability	NN
cord-321607-3r736dnk	350	3	to	to	TO
cord-321607-3r736dnk	350	4	polymerize	polymerize	VB
cord-321607-3r736dnk	350	5	actin	actin	NN
cord-321607-3r736dnk	350	6	would	would	MD
cord-321607-3r736dnk	350	7	severely	severely	RB
cord-321607-3r736dnk	350	8	diminish	diminish	VB
cord-321607-3r736dnk	350	9	active	active	JJ
cord-321607-3r736dnk	350	10	processes	process	NNS
cord-321607-3r736dnk	350	11	like	like	IN
cord-321607-3r736dnk	350	12	endocytosis	endocytosis	NN
cord-321607-3r736dnk	350	13	and	and	CC
cord-321607-3r736dnk	350	14	cell	cell	NN
cord-321607-3r736dnk	350	15	migration	migration	NN
cord-321607-3r736dnk	350	16	.	.	.
cord-321607-3r736dnk	351	1	This	this	DT
cord-321607-3r736dnk	351	2	ASC	ASC	NNP
cord-321607-3r736dnk	351	3	-	-	HYPH
cord-321607-3r736dnk	351	4	mediated	mediate	VBN
cord-321607-3r736dnk	351	5	indirect	indirect	JJ
cord-321607-3r736dnk	351	6	regulation	regulation	NN
cord-321607-3r736dnk	351	7	of	of	IN
cord-321607-3r736dnk	351	8	actin	actin	NN
cord-321607-3r736dnk	351	9	polymerization	polymerization	NN
cord-321607-3r736dnk	351	10	may	may	MD
cord-321607-3r736dnk	351	11	serve	serve	VB
cord-321607-3r736dnk	351	12	to	to	TO
cord-321607-3r736dnk	351	13	stabilize	stabilize	VB
cord-321607-3r736dnk	351	14	the	the	DT
cord-321607-3r736dnk	351	15	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	351	16	and	and	CC
cord-321607-3r736dnk	351	17	enhance	enhance	VB
cord-321607-3r736dnk	351	18	barrier	barrier	NN
cord-321607-3r736dnk	351	19	function	function	NN
cord-321607-3r736dnk	351	20	.	.	.
cord-321607-3r736dnk	352	1	Pyrin	Pyrin	NNP
cord-321607-3r736dnk	352	2	:	:	:
cord-321607-3r736dnk	352	3	Pyrin	Pyrin	NNP
cord-321607-3r736dnk	352	4	is	be	VBZ
cord-321607-3r736dnk	352	5	an	an	DT
cord-321607-3r736dnk	352	6	inflammasome	inflammasome	NN
cord-321607-3r736dnk	352	7	receptor	receptor	NN
cord-321607-3r736dnk	352	8	that	that	WDT
cord-321607-3r736dnk	352	9	interacts	interact	VBZ
cord-321607-3r736dnk	352	10	with	with	IN
cord-321607-3r736dnk	352	11	microtubules	microtubule	NNS
cord-321607-3r736dnk	352	12	and	and	CC
cord-321607-3r736dnk	352	13	actin	actin	NN
cord-321607-3r736dnk	352	14	filaments	filament	NNS
cord-321607-3r736dnk	352	15	.	.	.
cord-321607-3r736dnk	353	1	Utilizing	utilize	VBG
cord-321607-3r736dnk	353	2	a	a	DT
cord-321607-3r736dnk	353	3	mouse	mouse	NN
cord-321607-3r736dnk	353	4	model	model	NN
cord-321607-3r736dnk	353	5	in	in	IN
cord-321607-3r736dnk	353	6	which	which	WDT
cord-321607-3r736dnk	353	7	the	the	DT
cord-321607-3r736dnk	353	8	actin	actin	NN
cord-321607-3r736dnk	353	9	depolymerizing	depolymerizing	NN
cord-321607-3r736dnk	353	10	factor	factor	NN
cord-321607-3r736dnk	353	11	Wdr1	Wdr1	NNP
cord-321607-3r736dnk	353	12	was	be	VBD
cord-321607-3r736dnk	353	13	mutated	mutate	VBN
cord-321607-3r736dnk	353	14	,	,	,
cord-321607-3r736dnk	353	15	Kim	Kim	NNP
cord-321607-3r736dnk	353	16	et	et	NNP
cord-321607-3r736dnk	353	17	al	al	NNP
cord-321607-3r736dnk	353	18	.	.	.
cord-321607-3r736dnk	354	1	[	[	-LRB-
cord-321607-3r736dnk	354	2	135	135	CD
cord-321607-3r736dnk	354	3	]	]	-RRB-
cord-321607-3r736dnk	354	4	demonstrated	demonstrate	VBD
cord-321607-3r736dnk	354	5	that	that	IN
cord-321607-3r736dnk	354	6	the	the	DT
cord-321607-3r736dnk	354	7	perturbation	perturbation	NN
cord-321607-3r736dnk	354	8	of	of	IN
cord-321607-3r736dnk	354	9	actin	actin	NN
cord-321607-3r736dnk	354	10	resulted	result	VBD
cord-321607-3r736dnk	354	11	in	in	IN
cord-321607-3r736dnk	354	12	autoinflammation	autoinflammation	NN
cord-321607-3r736dnk	354	13	that	that	WDT
cord-321607-3r736dnk	354	14	is	be	VBZ
cord-321607-3r736dnk	354	15	dependent	dependent	JJ
cord-321607-3r736dnk	354	16	on	on	IN
cord-321607-3r736dnk	354	17	the	the	DT
cord-321607-3r736dnk	354	18	pyrin	pyrin	NNP
cord-321607-3r736dnk	354	19	inflammasome	inflammasome	NNP
cord-321607-3r736dnk	354	20	and	and	CC
cord-321607-3r736dnk	354	21	activation	activation	NN
cord-321607-3r736dnk	354	22	of	of	IN
cord-321607-3r736dnk	354	23	IL-18	IL-18	NNP
cord-321607-3r736dnk	354	24	.	.	.
cord-321607-3r736dnk	355	1	The	the	DT
cord-321607-3r736dnk	355	2	Wdr1	Wdr1	NNP
cord-321607-3r736dnk	355	3	mutation	mutation	NN
cord-321607-3r736dnk	355	4	implies	imply	VBZ
cord-321607-3r736dnk	355	5	that	that	IN
cord-321607-3r736dnk	355	6	in	in	IN
cord-321607-3r736dnk	355	7	this	this	DT
cord-321607-3r736dnk	355	8	system	system	NN
cord-321607-3r736dnk	355	9	,	,	,
cord-321607-3r736dnk	355	10	excessive	excessive	JJ
cord-321607-3r736dnk	355	11	actin	actin	NN
cord-321607-3r736dnk	355	12	polymerization	polymerization	NN
cord-321607-3r736dnk	355	13	triggers	trigger	VBZ
cord-321607-3r736dnk	355	14	this	this	DT
cord-321607-3r736dnk	355	15	inflammasome	inflammasome	NN
cord-321607-3r736dnk	355	16	activation	activation	NN
cord-321607-3r736dnk	355	17	;	;	:
cord-321607-3r736dnk	355	18	however	however	RB
cord-321607-3r736dnk	355	19	,	,	,
cord-321607-3r736dnk	355	20	another	another	DT
cord-321607-3r736dnk	355	21	group	group	NN
cord-321607-3r736dnk	355	22	found	find	VBD
cord-321607-3r736dnk	355	23	that	that	IN
cord-321607-3r736dnk	355	24	decreased	decrease	VBD
cord-321607-3r736dnk	355	25	polymerization	polymerization	NN
cord-321607-3r736dnk	355	26	resulting	result	VBG
cord-321607-3r736dnk	355	27	from	from	IN
cord-321607-3r736dnk	355	28	bacterial	bacterial	JJ
cord-321607-3r736dnk	355	29	toxins	toxin	NNS
cord-321607-3r736dnk	355	30	targeting	target	VBG
cord-321607-3r736dnk	355	31	Rho	Rho	NNP
cord-321607-3r736dnk	355	32	GTPases	GTPases	NNP
cord-321607-3r736dnk	355	33	also	also	RB
cord-321607-3r736dnk	355	34	activated	activate	VBD
cord-321607-3r736dnk	355	35	the	the	DT
cord-321607-3r736dnk	355	36	pyrin	pyrin	NNP
cord-321607-3r736dnk	355	37	inflammasome	inflammasome	NNP
cord-321607-3r736dnk	355	38	[	[	-LRB-
cord-321607-3r736dnk	355	39	149	149	CD
cord-321607-3r736dnk	355	40	]	]	-RRB-
cord-321607-3r736dnk	355	41	.	.	.
cord-321607-3r736dnk	356	1	This	this	DT
cord-321607-3r736dnk	356	2	discrepancy	discrepancy	NN
cord-321607-3r736dnk	356	3	may	may	MD
cord-321607-3r736dnk	356	4	be	be	VB
cord-321607-3r736dnk	356	5	a	a	DT
cord-321607-3r736dnk	356	6	consequence	consequence	NN
cord-321607-3r736dnk	356	7	of	of	IN
cord-321607-3r736dnk	356	8	numerous	numerous	JJ
cord-321607-3r736dnk	356	9	differences	difference	NNS
cord-321607-3r736dnk	356	10	in	in	IN
cord-321607-3r736dnk	356	11	the	the	DT
cord-321607-3r736dnk	356	12	two	two	CD
cord-321607-3r736dnk	356	13	model	model	NN
cord-321607-3r736dnk	356	14	systems	system	NNS
cord-321607-3r736dnk	356	15	,	,	,
cord-321607-3r736dnk	356	16	however	however	RB
cord-321607-3r736dnk	356	17	both	both	DT
cord-321607-3r736dnk	356	18	reports	report	NNS
cord-321607-3r736dnk	356	19	demonstrate	demonstrate	VBP
cord-321607-3r736dnk	356	20	a	a	DT
cord-321607-3r736dnk	356	21	link	link	NN
cord-321607-3r736dnk	356	22	between	between	IN
cord-321607-3r736dnk	356	23	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	356	24	and	and	CC
cord-321607-3r736dnk	356	25	inflammasome	inflammasome	NN
cord-321607-3r736dnk	356	26	components	component	NNS
cord-321607-3r736dnk	356	27	that	that	WDT
cord-321607-3r736dnk	356	28	requires	require	VBZ
cord-321607-3r736dnk	356	29	further	further	JJ
cord-321607-3r736dnk	356	30	investigation	investigation	NN
cord-321607-3r736dnk	356	31	.	.	.
cord-321607-3r736dnk	357	1	PKR	PKR	NNP
cord-321607-3r736dnk	357	2	:	:	:
cord-321607-3r736dnk	358	1	PKR	PKR	NNP
cord-321607-3r736dnk	358	2	was	be	VBD
cord-321607-3r736dnk	358	3	found	find	VBN
cord-321607-3r736dnk	358	4	to	to	TO
cord-321607-3r736dnk	358	5	interact	interact	VB
cord-321607-3r736dnk	358	6	with	with	IN
cord-321607-3r736dnk	358	7	the	the	DT
cord-321607-3r736dnk	358	8	actin	actin	NN
cord-321607-3r736dnk	358	9	-	-	HYPH
cord-321607-3r736dnk	358	10	binding	bind	VBG
cord-321607-3r736dnk	358	11	protein	protein	NN
cord-321607-3r736dnk	358	12	gelsolin	gelsolin	NN
cord-321607-3r736dnk	358	13	,	,	,
cord-321607-3r736dnk	358	14	an	an	DT
cord-321607-3r736dnk	358	15	enzyme	enzyme	NN
cord-321607-3r736dnk	358	16	that	that	WDT
cord-321607-3r736dnk	358	17	catalyzes	catalyze	VBZ
cord-321607-3r736dnk	358	18	actin	actin	NN
cord-321607-3r736dnk	358	19	cleavage	cleavage	NN
cord-321607-3r736dnk	358	20	and	and	CC
cord-321607-3r736dnk	358	21	nucleation	nucleation	NN
cord-321607-3r736dnk	358	22	.	.	.
cord-321607-3r736dnk	359	1	Activation	activation	NN
cord-321607-3r736dnk	359	2	of	of	IN
cord-321607-3r736dnk	359	3	PKR	PKR	NNP
cord-321607-3r736dnk	359	4	by	by	IN
cord-321607-3r736dnk	359	5	dsRNA	dsrna	NN
cord-321607-3r736dnk	359	6	diminishes	diminish	VBZ
cord-321607-3r736dnk	359	7	the	the	DT
cord-321607-3r736dnk	359	8	interaction	interaction	NN
cord-321607-3r736dnk	359	9	with	with	IN
cord-321607-3r736dnk	359	10	gelsolin	gelsolin	NNP
cord-321607-3r736dnk	359	11	,	,	,
cord-321607-3r736dnk	359	12	as	as	IN
cord-321607-3r736dnk	359	13	gelsolin	gelsolin	NN
cord-321607-3r736dnk	359	14	is	be	VBZ
cord-321607-3r736dnk	359	15	only	only	RB
cord-321607-3r736dnk	359	16	capable	capable	JJ
cord-321607-3r736dnk	359	17	of	of	IN
cord-321607-3r736dnk	359	18	binding	bind	VBG
cord-321607-3r736dnk	359	19	to	to	IN
cord-321607-3r736dnk	359	20	PKR	PKR	NNP
cord-321607-3r736dnk	359	21	monomer	monomer	NN
cord-321607-3r736dnk	359	22	and	and	CC
cord-321607-3r736dnk	359	23	not	not	RB
cord-321607-3r736dnk	359	24	the	the	DT
cord-321607-3r736dnk	359	25	active	active	JJ
cord-321607-3r736dnk	359	26	dimeric	dimeric	JJ
cord-321607-3r736dnk	359	27	form	form	NN
cord-321607-3r736dnk	359	28	.	.	.
cord-321607-3r736dnk	360	1	In	in	IN
cord-321607-3r736dnk	360	2	its	-PRON-	PRP$
cord-321607-3r736dnk	360	3	latent	latent	JJ
cord-321607-3r736dnk	360	4	state	state	NN
cord-321607-3r736dnk	360	5	,	,	,
cord-321607-3r736dnk	360	6	PKR	PKR	NNP
cord-321607-3r736dnk	360	7	inhibits	inhibit	VBZ
cord-321607-3r736dnk	360	8	the	the	DT
cord-321607-3r736dnk	360	9	ability	ability	NN
cord-321607-3r736dnk	360	10	of	of	IN
cord-321607-3r736dnk	360	11	gelsolin	gelsolin	NN
cord-321607-3r736dnk	360	12	to	to	TO
cord-321607-3r736dnk	360	13	sever	sever	VB
cord-321607-3r736dnk	360	14	actin	actin	NN
cord-321607-3r736dnk	360	15	filaments	filament	NNS
cord-321607-3r736dnk	360	16	to	to	TO
cord-321607-3r736dnk	360	17	form	form	VB
cord-321607-3r736dnk	360	18	lammelopodia	lammelopodia	NNP
cord-321607-3r736dnk	360	19	.	.	.
cord-321607-3r736dnk	361	1	In	in	IN
cord-321607-3r736dnk	361	2	fact	fact	NN
cord-321607-3r736dnk	361	3	,	,	,
cord-321607-3r736dnk	361	4	actin	actin	NN
cord-321607-3r736dnk	361	5	staining	staining	NN
cord-321607-3r736dnk	361	6	of	of	IN
cord-321607-3r736dnk	361	7	PKR	PKR	NNP
cord-321607-3r736dnk	361	8	KO	KO	NNP
cord-321607-3r736dnk	361	9	and	and	CC
cord-321607-3r736dnk	361	10	WT	WT	NNP
cord-321607-3r736dnk	361	11	MEFs	mef	NNS
cord-321607-3r736dnk	361	12	indicate	indicate	VBP
cord-321607-3r736dnk	361	13	that	that	IN
cord-321607-3r736dnk	361	14	KO	KO	NNP
cord-321607-3r736dnk	361	15	cells	cell	NNS
cord-321607-3r736dnk	361	16	contain	contain	VBP
cord-321607-3r736dnk	361	17	less	less	JJR
cord-321607-3r736dnk	361	18	than	than	IN
cord-321607-3r736dnk	361	19	one	one	CD
cord-321607-3r736dnk	361	20	third	third	NN
cord-321607-3r736dnk	361	21	of	of	IN
cord-321607-3r736dnk	361	22	the	the	DT
cord-321607-3r736dnk	361	23	amount	amount	NN
cord-321607-3r736dnk	361	24	of	of	IN
cord-321607-3r736dnk	361	25	filamentous	filamentous	JJ
cord-321607-3r736dnk	361	26	actin	actin	NN
cord-321607-3r736dnk	361	27	as	as	IN
cord-321607-3r736dnk	361	28	WT	WT	NNP
cord-321607-3r736dnk	361	29	cells	cell	NNS
cord-321607-3r736dnk	361	30	.	.	.
cord-321607-3r736dnk	362	1	Given	give	VBN
cord-321607-3r736dnk	362	2	that	that	DT
cord-321607-3r736dnk	362	3	knockdown	knockdown	NN
cord-321607-3r736dnk	362	4	of	of	IN
cord-321607-3r736dnk	362	5	gelsolin	gelsolin	NNP
cord-321607-3r736dnk	362	6	inhibits	inhibit	VBZ
cord-321607-3r736dnk	362	7	virus	virus	NN
cord-321607-3r736dnk	362	8	uptake	uptake	NN
cord-321607-3r736dnk	362	9	,	,	,
cord-321607-3r736dnk	362	10	the	the	DT
cord-321607-3r736dnk	362	11	suppression	suppression	NN
cord-321607-3r736dnk	362	12	of	of	IN
cord-321607-3r736dnk	362	13	gelsolin	gelsolin	NN
cord-321607-3r736dnk	362	14	activity	activity	NN
cord-321607-3r736dnk	362	15	by	by	IN
cord-321607-3r736dnk	362	16	PKR	PKR	NNP
cord-321607-3r736dnk	362	17	represents	represent	VBZ
cord-321607-3r736dnk	362	18	a	a	DT
cord-321607-3r736dnk	362	19	novel	novel	JJ
cord-321607-3r736dnk	362	20	antiviral	antiviral	JJ
cord-321607-3r736dnk	362	21	mechanism	mechanism	NN
cord-321607-3r736dnk	362	22	[	[	-LRB-
cord-321607-3r736dnk	362	23	143	143	CD
cord-321607-3r736dnk	362	24	]	]	-RRB-
cord-321607-3r736dnk	362	25	.	.	.
cord-321607-3r736dnk	363	1	Caspase-11	Caspase-11	NNP
cord-321607-3r736dnk	363	2	and	and	CC
cord-321607-3r736dnk	363	3	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	363	4	:	:	:
cord-321607-3r736dnk	364	1	The	the	DT
cord-321607-3r736dnk	364	2	Yuan	Yuan	NNP
cord-321607-3r736dnk	364	3	lab	lab	NN
cord-321607-3r736dnk	364	4	has	have	VBZ
cord-321607-3r736dnk	364	5	identified	identify	VBN
cord-321607-3r736dnk	364	6	two	two	CD
cord-321607-3r736dnk	364	7	actin	actin	JJ
cord-321607-3r736dnk	364	8	-	-	HYPH
cord-321607-3r736dnk	364	9	associated	associate	VBN
cord-321607-3r736dnk	364	10	caspase-11	caspase-11	NNP
cord-321607-3r736dnk	364	11	interacting	interact	VBG
cord-321607-3r736dnk	364	12	proteins	protein	NNS
cord-321607-3r736dnk	364	13	,	,	,
cord-321607-3r736dnk	364	14	flightless	flightless	JJ
cord-321607-3r736dnk	364	15	and	and	CC
cord-321607-3r736dnk	364	16	actin	actin	NN
cord-321607-3r736dnk	364	17	interacting	interact	VBG
cord-321607-3r736dnk	364	18	protein	protein	NN
cord-321607-3r736dnk	364	19	1	1	CD
cord-321607-3r736dnk	364	20	(	(	-LRB-
cord-321607-3r736dnk	364	21	Aip1	Aip1	NNP
cord-321607-3r736dnk	364	22	)	)	-RRB-
cord-321607-3r736dnk	364	23	.	.	.
cord-321607-3r736dnk	365	1	Flightless	Flightless	NNP
cord-321607-3r736dnk	365	2	is	be	VBZ
cord-321607-3r736dnk	365	3	an	an	DT
cord-321607-3r736dnk	365	4	actin	actin	NN
cord-321607-3r736dnk	365	5	-	-	HYPH
cord-321607-3r736dnk	365	6	capping	cap	VBG
cord-321607-3r736dnk	365	7	protein	protein	NN
cord-321607-3r736dnk	365	8	and	and	CC
cord-321607-3r736dnk	365	9	a	a	DT
cord-321607-3r736dnk	365	10	member	member	NN
cord-321607-3r736dnk	365	11	of	of	IN
cord-321607-3r736dnk	365	12	the	the	DT
cord-321607-3r736dnk	365	13	gelsolin	gelsolin	NNP
cord-321607-3r736dnk	365	14	superfamily	superfamily	NN
cord-321607-3r736dnk	365	15	.	.	.
cord-321607-3r736dnk	366	1	It	-PRON-	PRP
cord-321607-3r736dnk	366	2	localizes	localize	VBZ
cord-321607-3r736dnk	366	3	caspase-11	caspase-11	XX
cord-321607-3r736dnk	366	4	to	to	IN
cord-321607-3r736dnk	366	5	the	the	DT
cord-321607-3r736dnk	366	6	leading	leading	JJ
cord-321607-3r736dnk	366	7	edge	edge	NN
cord-321607-3r736dnk	366	8	of	of	IN
cord-321607-3r736dnk	366	9	migrating	migrate	VBG
cord-321607-3r736dnk	366	10	cells	cell	NNS
cord-321607-3r736dnk	366	11	and	and	CC
cord-321607-3r736dnk	366	12	to	to	IN
cord-321607-3r736dnk	366	13	insoluble	insoluble	JJ
cord-321607-3r736dnk	366	14	cell	cell	NN
cord-321607-3r736dnk	366	15	fractions	fraction	NNS
cord-321607-3r736dnk	366	16	.	.	.
cord-321607-3r736dnk	367	1	It	-PRON-	PRP
cord-321607-3r736dnk	367	2	also	also	RB
cord-321607-3r736dnk	367	3	binds	bind	VBZ
cord-321607-3r736dnk	367	4	to	to	IN
cord-321607-3r736dnk	367	5	and	and	CC
cord-321607-3r736dnk	367	6	inhibits	inhibit	VBZ
cord-321607-3r736dnk	367	7	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	367	8	activation	activation	NN
cord-321607-3r736dnk	367	9	and	and	CC
cord-321607-3r736dnk	367	10	subsequent	subsequent	JJ
cord-321607-3r736dnk	367	11	IL-1β	il-1β	DT
cord-321607-3r736dnk	367	12	maturation	maturation	NN
cord-321607-3r736dnk	367	13	.	.	.
cord-321607-3r736dnk	368	1	Analysis	analysis	NN
cord-321607-3r736dnk	368	2	of	of	IN
cord-321607-3r736dnk	368	3	flightless	flightless	JJ
cord-321607-3r736dnk	368	4	cleavage	cleavage	NN
cord-321607-3r736dnk	368	5	products	product	NNS
cord-321607-3r736dnk	368	6	indicates	indicate	VBZ
cord-321607-3r736dnk	368	7	that	that	IN
cord-321607-3r736dnk	368	8	it	-PRON-	PRP
cord-321607-3r736dnk	368	9	may	may	MD
cord-321607-3r736dnk	368	10	inhibit	inhibit	VB
cord-321607-3r736dnk	368	11	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	368	12	activity	activity	NN
cord-321607-3r736dnk	368	13	by	by	IN
cord-321607-3r736dnk	368	14	serving	serve	VBG
cord-321607-3r736dnk	368	15	as	as	IN
cord-321607-3r736dnk	368	16	a	a	DT
cord-321607-3r736dnk	368	17	pseudosubstrate	pseudosubstrate	NN
cord-321607-3r736dnk	368	18	for	for	IN
cord-321607-3r736dnk	368	19	its	-PRON-	PRP$
cord-321607-3r736dnk	368	20	catalytic	catalytic	JJ
cord-321607-3r736dnk	368	21	activity	activity	NN
cord-321607-3r736dnk	368	22	.	.	.
cord-321607-3r736dnk	369	1	This	this	DT
cord-321607-3r736dnk	369	2	inhibition	inhibition	NN
cord-321607-3r736dnk	369	3	of	of	IN
cord-321607-3r736dnk	369	4	caspase-1	caspase-1	NNP
cord-321607-3r736dnk	369	5	and	and	CC
cord-321607-3r736dnk	369	6	relocalization	relocalization	NN
cord-321607-3r736dnk	369	7	of	of	IN
cord-321607-3r736dnk	369	8	caspase-11	caspase-11	CD
cord-321607-3r736dnk	369	9	by	by	IN
cord-321607-3r736dnk	369	10	flightless	flightless	NN
cord-321607-3r736dnk	369	11	could	could	MD
cord-321607-3r736dnk	369	12	suppress	suppress	VB
cord-321607-3r736dnk	369	13	pro	pro	JJ
cord-321607-3r736dnk	369	14	-	-	JJ
cord-321607-3r736dnk	369	15	IL-1β	il-1β	JJ
cord-321607-3r736dnk	369	16	processing	processing	NN
cord-321607-3r736dnk	369	17	to	to	IN
cord-321607-3r736dnk	369	18	the	the	DT
cord-321607-3r736dnk	369	19	secreted	secrete	VBN
cord-321607-3r736dnk	369	20	form	form	NN
cord-321607-3r736dnk	369	21	,	,	,
cord-321607-3r736dnk	369	22	thus	thus	RB
cord-321607-3r736dnk	369	23	dysregulating	dysregulate	VBG
cord-321607-3r736dnk	369	24	the	the	DT
cord-321607-3r736dnk	369	25	inflammatory	inflammatory	JJ
cord-321607-3r736dnk	369	26	response	response	NN
cord-321607-3r736dnk	369	27	[	[	-LRB-
cord-321607-3r736dnk	369	28	141	141	CD
cord-321607-3r736dnk	369	29	,	,	,
cord-321607-3r736dnk	369	30	150	150	CD
cord-321607-3r736dnk	369	31	,	,	,
cord-321607-3r736dnk	369	32	151	151	CD
cord-321607-3r736dnk	369	33	]	]	-RRB-
cord-321607-3r736dnk	369	34	.	.	.
cord-321607-3r736dnk	370	1	Aip1	Aip1	NNP
cord-321607-3r736dnk	370	2	activates	activate	VBZ
cord-321607-3r736dnk	370	3	cofilin	cofilin	NN
cord-321607-3r736dnk	370	4	-	-	HYPH
cord-321607-3r736dnk	370	5	mediated	mediate	VBN
cord-321607-3r736dnk	370	6	actin	actin	NN
cord-321607-3r736dnk	370	7	depolymerization	depolymerization	NN
cord-321607-3r736dnk	370	8	.	.	.
cord-321607-3r736dnk	371	1	Binding	bind	VBG
cord-321607-3r736dnk	371	2	to	to	IN
cord-321607-3r736dnk	371	3	caspase-11	caspase-11	NNP
cord-321607-3r736dnk	371	4	enhances	enhance	VBZ
cord-321607-3r736dnk	371	5	this	this	DT
cord-321607-3r736dnk	371	6	polymerization	polymerization	NN
cord-321607-3r736dnk	371	7	by	by	IN
cord-321607-3r736dnk	371	8	a	a	DT
cord-321607-3r736dnk	371	9	mechanism	mechanism	NN
cord-321607-3r736dnk	371	10	independent	independent	JJ
cord-321607-3r736dnk	371	11	of	of	IN
cord-321607-3r736dnk	371	12	caspase	caspase	JJ
cord-321607-3r736dnk	371	13	activity	activity	NN
cord-321607-3r736dnk	371	14	and	and	CC
cord-321607-3r736dnk	371	15	leads	lead	VBZ
cord-321607-3r736dnk	371	16	to	to	IN
cord-321607-3r736dnk	371	17	enhanced	enhanced	JJ
cord-321607-3r736dnk	371	18	migration	migration	NN
cord-321607-3r736dnk	371	19	during	during	IN
cord-321607-3r736dnk	371	20	inflammation	inflammation	NN
cord-321607-3r736dnk	371	21	[	[	-LRB-
cord-321607-3r736dnk	371	22	144	144	CD
cord-321607-3r736dnk	371	23	]	]	-RRB-
cord-321607-3r736dnk	371	24	.	.	.
cord-321607-3r736dnk	372	1	IFITM1	IFITM1	NNP
cord-321607-3r736dnk	372	2	:	:	:
cord-321607-3r736dnk	373	1	Interferon	interferon	NN
cord-321607-3r736dnk	373	2	-	-	HYPH
cord-321607-3r736dnk	373	3	induced	induce	VBN
cord-321607-3r736dnk	373	4	transmembrane	transmembrane	NN
cord-321607-3r736dnk	373	5	protein	protein	NN
cord-321607-3r736dnk	373	6	1	1	CD
cord-321607-3r736dnk	373	7	(	(	-LRB-
cord-321607-3r736dnk	373	8	IFITM1	IFITM1	NNP
cord-321607-3r736dnk	373	9	)	)	-RRB-
cord-321607-3r736dnk	373	10	is	be	VBZ
cord-321607-3r736dnk	373	11	one	one	CD
cord-321607-3r736dnk	373	12	of	of	IN
cord-321607-3r736dnk	373	13	hundreds	hundred	NNS
cord-321607-3r736dnk	373	14	of	of	IN
cord-321607-3r736dnk	373	15	IFN	IFN	NNP
cord-321607-3r736dnk	373	16	-	-	HYPH
cord-321607-3r736dnk	373	17	stimulated	stimulate	VBN
cord-321607-3r736dnk	373	18	genes	gene	NNS
cord-321607-3r736dnk	373	19	.	.	.
cord-321607-3r736dnk	374	1	In	in	IN
cord-321607-3r736dnk	374	2	hepatocytes	hepatocyte	NNS
cord-321607-3r736dnk	374	3	,	,	,
cord-321607-3r736dnk	374	4	it	-PRON-	PRP
cord-321607-3r736dnk	374	5	was	be	VBD
cord-321607-3r736dnk	374	6	found	find	VBN
cord-321607-3r736dnk	374	7	to	to	TO
cord-321607-3r736dnk	374	8	accumulate	accumulate	VB
cord-321607-3r736dnk	374	9	in	in	IN
cord-321607-3r736dnk	374	10	tight	tight	JJ
cord-321607-3r736dnk	374	11	junctions	junction	NNS
cord-321607-3r736dnk	374	12	in	in	IN
cord-321607-3r736dnk	374	13	HCV	HCV	NNP
cord-321607-3r736dnk	374	14	-	-	HYPH
cord-321607-3r736dnk	374	15	infected	infect	VBN
cord-321607-3r736dnk	374	16	patients	patient	NNS
cord-321607-3r736dnk	374	17	undergoing	undergo	VBG
cord-321607-3r736dnk	374	18	IFN	IFN	NNP
cord-321607-3r736dnk	374	19	therapy	therapy	NN
cord-321607-3r736dnk	374	20	.	.	.
cord-321607-3r736dnk	375	1	It	-PRON-	PRP
cord-321607-3r736dnk	375	2	bound	bind	VBN
cord-321607-3r736dnk	375	3	to	to	IN
cord-321607-3r736dnk	375	4	the	the	DT
cord-321607-3r736dnk	375	5	tight	tight	JJ
cord-321607-3r736dnk	375	6	junction	junction	NN
cord-321607-3r736dnk	375	7	proteins	protein	NNS
cord-321607-3r736dnk	375	8	occludin	occludin	NNP
cord-321607-3r736dnk	375	9	,	,	,
cord-321607-3r736dnk	375	10	claudin-1	claudin-1	NNP
cord-321607-3r736dnk	375	11	,	,	,
cord-321607-3r736dnk	375	12	and	and	CC
cord-321607-3r736dnk	375	13	ZO-1	ZO-1	NNP
cord-321607-3r736dnk	375	14	,	,	,
cord-321607-3r736dnk	375	15	and	and	CC
cord-321607-3r736dnk	375	16	appeared	appear	VBD
cord-321607-3r736dnk	375	17	to	to	TO
cord-321607-3r736dnk	375	18	enhance	enhance	VB
cord-321607-3r736dnk	375	19	the	the	DT
cord-321607-3r736dnk	375	20	interaction	interaction	NN
cord-321607-3r736dnk	375	21	between	between	IN
cord-321607-3r736dnk	375	22	the	the	DT
cord-321607-3r736dnk	375	23	HCV	HCV	NNP
cord-321607-3r736dnk	375	24	coreceptors	coreceptor	NNS
cord-321607-3r736dnk	375	25	occludin	occludin	NNP
cord-321607-3r736dnk	375	26	and	and	CC
cord-321607-3r736dnk	375	27	CD81	CD81	NNP
cord-321607-3r736dnk	375	28	,	,	,
cord-321607-3r736dnk	375	29	yet	yet	CC
cord-321607-3r736dnk	375	30	inhibited	inhibit	VBN
cord-321607-3r736dnk	375	31	virus	virus	NN
cord-321607-3r736dnk	375	32	entry	entry	NN
cord-321607-3r736dnk	375	33	.	.	.
cord-321607-3r736dnk	376	1	It	-PRON-	PRP
cord-321607-3r736dnk	376	2	is	be	VBZ
cord-321607-3r736dnk	376	3	proposed	propose	VBN
cord-321607-3r736dnk	376	4	that	that	IN
cord-321607-3r736dnk	376	5	this	this	DT
cord-321607-3r736dnk	376	6	disruption	disruption	NN
cord-321607-3r736dnk	376	7	in	in	IN
cord-321607-3r736dnk	376	8	entry	entry	NN
cord-321607-3r736dnk	376	9	results	result	NNS
cord-321607-3r736dnk	376	10	from	from	IN
cord-321607-3r736dnk	376	11	the	the	DT
cord-321607-3r736dnk	376	12	altered	altered	JJ
cord-321607-3r736dnk	376	13	coordination	coordination	NN
cord-321607-3r736dnk	376	14	of	of	IN
cord-321607-3r736dnk	376	15	coreceptor	coreceptor	NN
cord-321607-3r736dnk	376	16	interactions	interaction	NNS
cord-321607-3r736dnk	376	17	and	and	CC
cord-321607-3r736dnk	376	18	complex	complex	JJ
cord-321607-3r736dnk	376	19	formation	formation	NN
cord-321607-3r736dnk	376	20	,	,	,
cord-321607-3r736dnk	376	21	however	however	RB
cord-321607-3r736dnk	376	22	this	this	DT
cord-321607-3r736dnk	376	23	mechanism	mechanism	NN
cord-321607-3r736dnk	376	24	requires	require	VBZ
cord-321607-3r736dnk	376	25	further	further	JJ
cord-321607-3r736dnk	376	26	investigation	investigation	NN
cord-321607-3r736dnk	376	27	[	[	-LRB-
cord-321607-3r736dnk	376	28	146	146	CD
cord-321607-3r736dnk	376	29	]	]	-RRB-
cord-321607-3r736dnk	376	30	.	.	.
cord-321607-3r736dnk	377	1	ADAP2	ADAP2	NNP
cord-321607-3r736dnk	377	2	:	:	:
cord-321607-3r736dnk	377	3	ADAP2	ADAP2	NNP
cord-321607-3r736dnk	378	1	(	(	-LRB-
cord-321607-3r736dnk	378	2	ADP	ADP	NNP
cord-321607-3r736dnk	378	3	-	-	HYPH
cord-321607-3r736dnk	378	4	ribosylation	ribosylation	NN
cord-321607-3r736dnk	378	5	factor	factor	NN
cord-321607-3r736dnk	379	1	(	(	-LRB-
cord-321607-3r736dnk	379	2	Arf	Arf	NNP
cord-321607-3r736dnk	379	3	)	)	-RRB-
cord-321607-3r736dnk	379	4	GTPase	GTPase	NNP
cord-321607-3r736dnk	379	5	-	-	HYPH
cord-321607-3r736dnk	379	6	activating	activate	VBG
cord-321607-3r736dnk	379	7	protein	protein	NN
cord-321607-3r736dnk	379	8	(	(	-LRB-
cord-321607-3r736dnk	379	9	GAP	gap	NN
cord-321607-3r736dnk	379	10	)	)	-RRB-
cord-321607-3r736dnk	379	11	with	with	IN
cord-321607-3r736dnk	379	12	dual	dual	JJ
cord-321607-3r736dnk	379	13	pleckstrin	pleckstrin	NN
cord-321607-3r736dnk	379	14	homology	homology	NN
cord-321607-3r736dnk	379	15	domains	domain	NNS
cord-321607-3r736dnk	379	16	2	2	CD
cord-321607-3r736dnk	379	17	)	)	-RRB-
cord-321607-3r736dnk	379	18	is	be	VBZ
cord-321607-3r736dnk	379	19	an	an	DT
cord-321607-3r736dnk	379	20	IFN	IFN	NNP
cord-321607-3r736dnk	379	21	-	-	HYPH
cord-321607-3r736dnk	379	22	inducible	inducible	JJ
cord-321607-3r736dnk	379	23	,	,	,
cord-321607-3r736dnk	379	24	GTPase	GTPase	NNP
cord-321607-3r736dnk	379	25	-	-	HYPH
cord-321607-3r736dnk	379	26	activating	activate	VBG
cord-321607-3r736dnk	379	27	protein	protein	NN
cord-321607-3r736dnk	379	28	for	for	IN
cord-321607-3r736dnk	379	29	Arf6	Arf6	NNP
cord-321607-3r736dnk	379	30	.	.	.
cord-321607-3r736dnk	380	1	It	-PRON-	PRP
cord-321607-3r736dnk	380	2	associates	associate	VBZ
cord-321607-3r736dnk	380	3	with	with	IN
cord-321607-3r736dnk	380	4	and	and	CC
cord-321607-3r736dnk	380	5	can	can	MD
cord-321607-3r736dnk	380	6	control	control	VB
cord-321607-3r736dnk	380	7	actin	actin	NN
cord-321607-3r736dnk	380	8	dynamics	dynamic	NNS
cord-321607-3r736dnk	380	9	,	,	,
cord-321607-3r736dnk	380	10	as	as	RB
cord-321607-3r736dnk	380	11	well	well	RB
cord-321607-3r736dnk	380	12	as	as	IN
cord-321607-3r736dnk	380	13	induce	induce	VB
cord-321607-3r736dnk	380	14	membrane	membrane	NN
cord-321607-3r736dnk	380	15	ruffling	ruffling	NN
cord-321607-3r736dnk	380	16	and	and	CC
cord-321607-3r736dnk	380	17	macropinocytosis	macropinocytosis	NN
cord-321607-3r736dnk	380	18	,	,	,
cord-321607-3r736dnk	380	19	leading	lead	VBG
cord-321607-3r736dnk	380	20	to	to	IN
cord-321607-3r736dnk	380	21	the	the	DT
cord-321607-3r736dnk	380	22	formation	formation	NN
cord-321607-3r736dnk	380	23	of	of	IN
cord-321607-3r736dnk	380	24	ADAP2-associated	adap2-associate	VBN
cord-321607-3r736dnk	380	25	vesicles	vesicle	NNS
cord-321607-3r736dnk	380	26	.	.	.
cord-321607-3r736dnk	381	1	These	these	DT
cord-321607-3r736dnk	381	2	vesicles	vesicle	NNS
cord-321607-3r736dnk	381	3	are	be	VBP
cord-321607-3r736dnk	381	4	also	also	RB
cord-321607-3r736dnk	381	5	positive	positive	JJ
cord-321607-3r736dnk	381	6	for	for	IN
cord-321607-3r736dnk	381	7	Rab8a	rab8a	IN
cord-321607-3r736dnk	381	8	(	(	-LRB-
cord-321607-3r736dnk	381	9	recycling	recycling	NN
cord-321607-3r736dnk	381	10	endosomes	endosome	NNS
cord-321607-3r736dnk	381	11	)	)	-RRB-
cord-321607-3r736dnk	381	12	and	and	CC
cord-321607-3r736dnk	381	13	lysosomal	lysosomal	NN
cord-321607-3r736dnk	381	14	-	-	HYPH
cord-321607-3r736dnk	381	15	associated	associate	VBN
cord-321607-3r736dnk	381	16	membrane	membrane	NN
cord-321607-3r736dnk	381	17	protein	protein	NN
cord-321607-3r736dnk	381	18	1	1	CD
cord-321607-3r736dnk	381	19	(	(	-LRB-
cord-321607-3r736dnk	381	20	LAMP1	LAMP1	NNP
cord-321607-3r736dnk	381	21	;	;	:
cord-321607-3r736dnk	381	22	lysosomes	lysosome	NNS
cord-321607-3r736dnk	381	23	)	)	-RRB-
cord-321607-3r736dnk	381	24	.	.	.
cord-321607-3r736dnk	382	1	ADAP2	ADAP2	NNP
cord-321607-3r736dnk	382	2	expression	expression	NN
cord-321607-3r736dnk	382	3	shifts	shift	VBZ
cord-321607-3r736dnk	382	4	the	the	DT
cord-321607-3r736dnk	382	5	endocytic	endocytic	JJ
cord-321607-3r736dnk	382	6	association	association	NN
cord-321607-3r736dnk	382	7	of	of	IN
cord-321607-3r736dnk	382	8	Dengue	Dengue	NNP
cord-321607-3r736dnk	382	9	virus	virus	NN
cord-321607-3r736dnk	382	10	and	and	CC
cord-321607-3r736dnk	382	11	vesicular	vesicular	JJ
cord-321607-3r736dnk	382	12	stomatitis	stomatitis	NN
cord-321607-3r736dnk	382	13	virus	virus	NN
cord-321607-3r736dnk	382	14	(	(	-LRB-
cord-321607-3r736dnk	382	15	VSV	VSV	NNP
cord-321607-3r736dnk	382	16	)	)	-RRB-
cord-321607-3r736dnk	382	17	into	into	IN
cord-321607-3r736dnk	382	18	these	these	DT
cord-321607-3r736dnk	382	19	ADAP2-positive	ADAP2-positive	:
cord-321607-3r736dnk	382	20	vesicles	vesicle	NNS
cord-321607-3r736dnk	382	21	instead	instead	RB
cord-321607-3r736dnk	382	22	of	of	IN
cord-321607-3r736dnk	382	23	Rab5	Rab5	NNP
cord-321607-3r736dnk	382	24	and	and	CC
cord-321607-3r736dnk	382	25	Rab7	Rab7	NNP
cord-321607-3r736dnk	382	26	endosomes	endosome	NNS
cord-321607-3r736dnk	382	27	.	.	.
cord-321607-3r736dnk	383	1	This	this	DT
cord-321607-3r736dnk	383	2	not	not	RB
cord-321607-3r736dnk	383	3	only	only	RB
cord-321607-3r736dnk	383	4	inhibits	inhibit	VBZ
cord-321607-3r736dnk	383	5	their	-PRON-	PRP$
cord-321607-3r736dnk	383	6	entry	entry	NN
cord-321607-3r736dnk	383	7	into	into	IN
cord-321607-3r736dnk	383	8	the	the	DT
cord-321607-3r736dnk	383	9	cell	cell	NN
cord-321607-3r736dnk	383	10	but	but	CC
cord-321607-3r736dnk	383	11	also	also	RB
cord-321607-3r736dnk	383	12	likely	likely	RB
cord-321607-3r736dnk	383	13	delivers	deliver	VBZ
cord-321607-3r736dnk	383	14	the	the	DT
cord-321607-3r736dnk	383	15	viruses	virus	NNS
cord-321607-3r736dnk	383	16	directly	directly	RB
cord-321607-3r736dnk	383	17	to	to	IN
cord-321607-3r736dnk	383	18	degradative	degradative	JJ
cord-321607-3r736dnk	383	19	lysosomes	lysosome	NNS
cord-321607-3r736dnk	383	20	[	[	-LRB-
cord-321607-3r736dnk	383	21	145	145	CD
cord-321607-3r736dnk	383	22	]	]	-RRB-
cord-321607-3r736dnk	383	23	.	.	.
cord-321607-3r736dnk	384	1	The	the	DT
cord-321607-3r736dnk	384	2	emerging	emerge	VBG
cord-321607-3r736dnk	384	3	model	model	NN
cord-321607-3r736dnk	384	4	of	of	IN
cord-321607-3r736dnk	384	5	pathogen	pathogen	NN
cord-321607-3r736dnk	384	6	-	-	HYPH
cord-321607-3r736dnk	384	7	induced	induce	VBN
cord-321607-3r736dnk	384	8	actin	actin	NN
cord-321607-3r736dnk	384	9	alteration	alteration	NN
cord-321607-3r736dnk	384	10	as	as	IN
cord-321607-3r736dnk	384	11	a	a	DT
cord-321607-3r736dnk	384	12	sensor	sensor	NN
cord-321607-3r736dnk	384	13	and	and	CC
cord-321607-3r736dnk	384	14	regulator	regulator	NN
cord-321607-3r736dnk	384	15	of	of	IN
cord-321607-3r736dnk	384	16	immune	immune	JJ
cord-321607-3r736dnk	384	17	activation	activation	NN
cord-321607-3r736dnk	384	18	(	(	-LRB-
cord-321607-3r736dnk	384	19	Figure	figure	NN
cord-321607-3r736dnk	384	20	5	5	CD
cord-321607-3r736dnk	384	21	)	)	-RRB-
cord-321607-3r736dnk	384	22	involves	involve	VBZ
cord-321607-3r736dnk	384	23	the	the	DT
cord-321607-3r736dnk	384	24	contribution	contribution	NN
cord-321607-3r736dnk	384	25	of	of	IN
cord-321607-3r736dnk	384	26	a	a	DT
cord-321607-3r736dnk	384	27	diverse	diverse	JJ
cord-321607-3r736dnk	384	28	profile	profile	NN
cord-321607-3r736dnk	384	29	of	of	IN
cord-321607-3r736dnk	384	30	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	384	31	and	and	CC
cord-321607-3r736dnk	384	32	innate	innate	JJ
cord-321607-3r736dnk	384	33	immune	immune	JJ
cord-321607-3r736dnk	384	34	components	component	NNS
cord-321607-3r736dnk	384	35	(	(	-LRB-
cord-321607-3r736dnk	384	36	Table	table	NN
cord-321607-3r736dnk	384	37	1	1	CD
cord-321607-3r736dnk	384	38	)	)	-RRB-
cord-321607-3r736dnk	384	39	.	.	.
cord-321607-3r736dnk	385	1	Interestingly	interestingly	RB
cord-321607-3r736dnk	385	2	,	,	,
cord-321607-3r736dnk	385	3	functional	functional	JJ
cord-321607-3r736dnk	385	4	roles	role	NNS
cord-321607-3r736dnk	385	5	for	for	IN
cord-321607-3r736dnk	385	6	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	385	7	proteins	protein	NNS
cord-321607-3r736dnk	385	8	in	in	IN
cord-321607-3r736dnk	385	9	the	the	DT
cord-321607-3r736dnk	385	10	innate	innate	JJ
cord-321607-3r736dnk	385	11	immune	immune	JJ
cord-321607-3r736dnk	385	12	response	response	NN
cord-321607-3r736dnk	385	13	appears	appear	VBZ
cord-321607-3r736dnk	385	14	to	to	TO
cord-321607-3r736dnk	385	15	occur	occur	VB
cord-321607-3r736dnk	385	16	primarily	primarily	RB
cord-321607-3r736dnk	385	17	through	through	IN
cord-321607-3r736dnk	385	18	an	an	DT
cord-321607-3r736dnk	385	19	intersection	intersection	NN
cord-321607-3r736dnk	385	20	with	with	IN
cord-321607-3r736dnk	385	21	RLR	RLR	NNP
cord-321607-3r736dnk	385	22	and	and	CC
cord-321607-3r736dnk	385	23	inflammasome	inflammasome	NN
cord-321607-3r736dnk	385	24	pathways	pathway	NNS
cord-321607-3r736dnk	385	25	,	,	,
cord-321607-3r736dnk	385	26	whereas	whereas	IN
cord-321607-3r736dnk	385	27	few	few	JJ
cord-321607-3r736dnk	385	28	TLR	TLR	NNP
cord-321607-3r736dnk	385	29	signaling	signal	VBG
cord-321607-3r736dnk	385	30	components	component	NNS
cord-321607-3r736dnk	385	31	have	have	VBP
cord-321607-3r736dnk	385	32	been	be	VBN
cord-321607-3r736dnk	385	33	identified	identify	VBN
cord-321607-3r736dnk	385	34	.	.	.
cord-321607-3r736dnk	386	1	Whether	whether	IN
cord-321607-3r736dnk	386	2	this	this	DT
cord-321607-3r736dnk	386	3	is	be	VBZ
cord-321607-3r736dnk	386	4	a	a	DT
cord-321607-3r736dnk	386	5	fundamental	fundamental	JJ
cord-321607-3r736dnk	386	6	difference	difference	NN
cord-321607-3r736dnk	386	7	between	between	IN
cord-321607-3r736dnk	386	8	cytosolic	cytosolic	JJ
cord-321607-3r736dnk	386	9	receptors	receptor	NNS
cord-321607-3r736dnk	386	10	and	and	CC
cord-321607-3r736dnk	386	11	membrane	membrane	NN
cord-321607-3r736dnk	386	12	receptors	receptor	NNS
cord-321607-3r736dnk	386	13	,	,	,
cord-321607-3r736dnk	386	14	or	or	CC
cord-321607-3r736dnk	386	15	if	if	IN
cord-321607-3r736dnk	386	16	TLR	TLR	NNP
cord-321607-3r736dnk	386	17	interactors	interactor	NNS
cord-321607-3r736dnk	386	18	simply	simply	RB
cord-321607-3r736dnk	386	19	have	have	VBP
cord-321607-3r736dnk	386	20	yet	yet	RB
cord-321607-3r736dnk	386	21	to	to	TO
cord-321607-3r736dnk	386	22	be	be	VB
cord-321607-3r736dnk	386	23	found	find	VBN
cord-321607-3r736dnk	386	24	,	,	,
cord-321607-3r736dnk	386	25	is	be	VBZ
cord-321607-3r736dnk	386	26	still	still	RB
cord-321607-3r736dnk	386	27	to	to	TO
cord-321607-3r736dnk	386	28	be	be	VB
cord-321607-3r736dnk	386	29	determined	determine	VBN
cord-321607-3r736dnk	386	30	.	.	.
cord-321607-3r736dnk	387	1	If	if	IN
cord-321607-3r736dnk	387	2	these	these	DT
cord-321607-3r736dnk	387	3	interactions	interaction	NNS
cord-321607-3r736dnk	387	4	are	be	VBP
cord-321607-3r736dnk	387	5	truly	truly	RB
cord-321607-3r736dnk	387	6	beginning	begin	VBG
cord-321607-3r736dnk	387	7	to	to	TO
cord-321607-3r736dnk	387	8	define	define	VB
cord-321607-3r736dnk	387	9	a	a	DT
cord-321607-3r736dnk	387	10	regulatory	regulatory	JJ
cord-321607-3r736dnk	387	11	mechanism	mechanism	NN
cord-321607-3r736dnk	387	12	for	for	IN
cord-321607-3r736dnk	387	13	innate	innate	JJ
cord-321607-3r736dnk	387	14	immune	immune	JJ
cord-321607-3r736dnk	387	15	activity	activity	NN
cord-321607-3r736dnk	387	16	,	,	,
cord-321607-3r736dnk	387	17	it	-PRON-	PRP
cord-321607-3r736dnk	387	18	is	be	VBZ
cord-321607-3r736dnk	387	19	interesting	interesting	JJ
cord-321607-3r736dnk	387	20	to	to	TO
cord-321607-3r736dnk	387	21	speculate	speculate	VB
cord-321607-3r736dnk	387	22	as	as	IN
cord-321607-3r736dnk	387	23	to	to	IN
cord-321607-3r736dnk	387	24	why	why	WRB
cord-321607-3r736dnk	387	25	it	-PRON-	PRP
cord-321607-3r736dnk	387	26	may	may	MD
cord-321607-3r736dnk	387	27	have	have	VB
cord-321607-3r736dnk	387	28	developed	develop	VBN
cord-321607-3r736dnk	387	29	.	.	.
cord-321607-3r736dnk	388	1	Viruses	virus	NNS
cord-321607-3r736dnk	388	2	and	and	CC
cord-321607-3r736dnk	388	3	bacteria	bacteria	NNS
cord-321607-3r736dnk	388	4	manipulate	manipulate	VBP
cord-321607-3r736dnk	388	5	the	the	DT
cord-321607-3r736dnk	388	6	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	388	7	throughout	throughout	IN
cord-321607-3r736dnk	388	8	the	the	DT
cord-321607-3r736dnk	388	9	course	course	NN
cord-321607-3r736dnk	388	10	of	of	IN
cord-321607-3r736dnk	388	11	infection	infection	NN
cord-321607-3r736dnk	388	12	.	.	.
cord-321607-3r736dnk	389	1	Bacteria	Bacteria	NNS
cord-321607-3r736dnk	389	2	utilize	utilize	VBP
cord-321607-3r736dnk	389	3	actin	actin	NN
cord-321607-3r736dnk	389	4	polymerization	polymerization	NN
cord-321607-3r736dnk	389	5	for	for	IN
cord-321607-3r736dnk	389	6	many	many	JJ
cord-321607-3r736dnk	389	7	purposes	purpose	NNS
cord-321607-3r736dnk	389	8	such	such	JJ
cord-321607-3r736dnk	389	9	as	as	IN
cord-321607-3r736dnk	389	10	forming	form	VBG
cord-321607-3r736dnk	389	11	pedestals	pedestal	NNS
cord-321607-3r736dnk	389	12	to	to	TO
cord-321607-3r736dnk	389	13	mediate	mediate	VB
cord-321607-3r736dnk	389	14	attachment	attachment	NN
cord-321607-3r736dnk	389	15	and	and	CC
cord-321607-3r736dnk	389	16	invasion	invasion	NN
cord-321607-3r736dnk	389	17	,	,	,
cord-321607-3r736dnk	389	18	generating	generate	VBG
cord-321607-3r736dnk	389	19	actin	actin	JJ
cord-321607-3r736dnk	389	20	tails	tail	NNS
cord-321607-3r736dnk	389	21	for	for	IN
cord-321607-3r736dnk	389	22	disseminating	disseminate	VBG
cord-321607-3r736dnk	389	23	throughout	throughout	IN
cord-321607-3r736dnk	389	24	the	the	DT
cord-321607-3r736dnk	389	25	cytosol	cytosol	NN
cord-321607-3r736dnk	389	26	,	,	,
cord-321607-3r736dnk	389	27	or	or	CC
cord-321607-3r736dnk	389	28	to	to	TO
cord-321607-3r736dnk	389	29	mediate	mediate	VB
cord-321607-3r736dnk	389	30	intercellular	intercellular	JJ
cord-321607-3r736dnk	389	31	spread	spread	NN
cord-321607-3r736dnk	389	32	[	[	-LRB-
cord-321607-3r736dnk	389	33	133	133	CD
cord-321607-3r736dnk	389	34	]	]	-RRB-
cord-321607-3r736dnk	389	35	.	.	.
cord-321607-3r736dnk	390	1	Viruses	virus	NNS
cord-321607-3r736dnk	390	2	remodel	remodel	VBP
cord-321607-3r736dnk	390	3	actin	actin	NN
cord-321607-3r736dnk	390	4	for	for	IN
cord-321607-3r736dnk	390	5	almost	almost	RB
cord-321607-3r736dnk	390	6	every	every	DT
cord-321607-3r736dnk	390	7	step	step	NN
cord-321607-3r736dnk	390	8	of	of	IN
cord-321607-3r736dnk	390	9	replication	replication	NN
cord-321607-3r736dnk	390	10	including	include	VBG
cord-321607-3r736dnk	390	11	invasion	invasion	NN
cord-321607-3r736dnk	390	12	,	,	,
cord-321607-3r736dnk	390	13	migration	migration	NN
cord-321607-3r736dnk	390	14	to	to	IN
cord-321607-3r736dnk	390	15	the	the	DT
cord-321607-3r736dnk	390	16	nucleus	nucleus	NN
cord-321607-3r736dnk	390	17	,	,	,
cord-321607-3r736dnk	390	18	assembly	assembly	NN
cord-321607-3r736dnk	390	19	,	,	,
cord-321607-3r736dnk	390	20	exocytosis	exocytosis	NN
cord-321607-3r736dnk	390	21	,	,	,
cord-321607-3r736dnk	390	22	and	and	CC
cord-321607-3r736dnk	390	23	budding	bud	VBG
cord-321607-3r736dnk	390	24	[	[	-LRB-
cord-321607-3r736dnk	390	25	134	134	CD
cord-321607-3r736dnk	390	26	]	]	-RRB-
cord-321607-3r736dnk	390	27	.	.	.
cord-321607-3r736dnk	391	1	These	these	DT
cord-321607-3r736dnk	391	2	are	be	VBP
cord-321607-3r736dnk	391	3	all	all	DT
cord-321607-3r736dnk	391	4	conserved	conserve	VBN
cord-321607-3r736dnk	391	5	and	and	CC
cord-321607-3r736dnk	391	6	universal	universal	JJ
cord-321607-3r736dnk	391	7	activities	activity	NNS
cord-321607-3r736dnk	391	8	that	that	WDT
cord-321607-3r736dnk	391	9	are	be	VBP
cord-321607-3r736dnk	391	10	unlikely	unlikely	JJ
cord-321607-3r736dnk	391	11	to	to	TO
cord-321607-3r736dnk	391	12	be	be	VB
cord-321607-3r736dnk	391	13	lost	lose	VBN
cord-321607-3r736dnk	391	14	through	through	IN
cord-321607-3r736dnk	391	15	adaptation	adaptation	NN
cord-321607-3r736dnk	391	16	,	,	,
cord-321607-3r736dnk	391	17	and	and	CC
cord-321607-3r736dnk	391	18	therefore	therefore	RB
cord-321607-3r736dnk	391	19	make	make	VB
cord-321607-3r736dnk	391	20	pathogen	pathogen	NN
cord-321607-3r736dnk	391	21	-	-	HYPH
cord-321607-3r736dnk	391	22	induced	induce	VBN
cord-321607-3r736dnk	391	23	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	391	24	perturbations	perturbation	NNS
cord-321607-3r736dnk	391	25	good	good	JJ
cord-321607-3r736dnk	391	26	targets	target	NNS
cord-321607-3r736dnk	391	27	for	for	IN
cord-321607-3r736dnk	391	28	innate	innate	JJ
cord-321607-3r736dnk	391	29	immune	immune	JJ
cord-321607-3r736dnk	391	30	activation	activation	NN
cord-321607-3r736dnk	391	31	.	.	.
cord-321607-3r736dnk	392	1	Most	Most	JJS
cord-321607-3r736dnk	392	2	of	of	IN
cord-321607-3r736dnk	392	3	these	these	DT
cord-321607-3r736dnk	392	4	interactions	interaction	NNS
cord-321607-3r736dnk	392	5	localize	localize	VBP
cord-321607-3r736dnk	392	6	normally	normally	RB
cord-321607-3r736dnk	392	7	cytosolic	cytosolic	JJ
cord-321607-3r736dnk	392	8	innate	innate	JJ
cord-321607-3r736dnk	392	9	signaling	signal	VBG
cord-321607-3r736dnk	392	10	molecules	molecule	NNS
cord-321607-3r736dnk	392	11	to	to	IN
cord-321607-3r736dnk	392	12	the	the	DT
cord-321607-3r736dnk	392	13	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	392	14	,	,	,
cord-321607-3r736dnk	392	15	particularly	particularly	RB
cord-321607-3r736dnk	392	16	to	to	IN
cord-321607-3r736dnk	392	17	the	the	DT
cord-321607-3r736dnk	392	18	cell	cell	NN
cord-321607-3r736dnk	392	19	membrane	membrane	NN
cord-321607-3r736dnk	392	20	or	or	CC
cord-321607-3r736dnk	392	21	tight	tight	JJ
cord-321607-3r736dnk	392	22	junctions	junction	NNS
cord-321607-3r736dnk	392	23	.	.	.
cord-321607-3r736dnk	393	1	Several	several	JJ
cord-321607-3r736dnk	393	2	viruses	virus	NNS
cord-321607-3r736dnk	393	3	,	,	,
cord-321607-3r736dnk	393	4	such	such	JJ
cord-321607-3r736dnk	393	5	as	as	IN
cord-321607-3r736dnk	393	6	HCV	HCV	NNP
cord-321607-3r736dnk	393	7	and	and	CC
cord-321607-3r736dnk	393	8	Coxsackievirus	Coxsackievirus	NNP
cord-321607-3r736dnk	393	9	,	,	,
cord-321607-3r736dnk	393	10	bind	bind	VB
cord-321607-3r736dnk	393	11	to	to	IN
cord-321607-3r736dnk	393	12	receptors	receptor	NNS
cord-321607-3r736dnk	393	13	located	locate	VBN
cord-321607-3r736dnk	393	14	at	at	IN
cord-321607-3r736dnk	393	15	tight	tight	JJ
cord-321607-3r736dnk	393	16	junctions	junction	NNS
cord-321607-3r736dnk	393	17	,	,	,
cord-321607-3r736dnk	393	18	making	make	VBG
cord-321607-3r736dnk	393	19	this	this	DT
cord-321607-3r736dnk	393	20	site	site	NN
cord-321607-3r736dnk	393	21	an	an	DT
cord-321607-3r736dnk	393	22	ideal	ideal	JJ
cord-321607-3r736dnk	393	23	location	location	NN
cord-321607-3r736dnk	393	24	for	for	IN
cord-321607-3r736dnk	393	25	innate	innate	JJ
cord-321607-3r736dnk	393	26	immune	immune	JJ
cord-321607-3r736dnk	393	27	activators	activator	NNS
cord-321607-3r736dnk	393	28	[	[	-LRB-
cord-321607-3r736dnk	393	29	152	152	CD
cord-321607-3r736dnk	393	30	,	,	,
cord-321607-3r736dnk	393	31	153	153	CD
cord-321607-3r736dnk	393	32	]	]	-RRB-
cord-321607-3r736dnk	393	33	.	.	.
cord-321607-3r736dnk	394	1	Similarly	similarly	RB
cord-321607-3r736dnk	394	2	,	,	,
cord-321607-3r736dnk	394	3	RNase	RNase	NNP
cord-321607-3r736dnk	394	4	-	-	HYPH
cord-321607-3r736dnk	394	5	L	L	NNP
cord-321607-3r736dnk	394	6	,	,	,
cord-321607-3r736dnk	394	7	PKR	PKR	NNP
cord-321607-3r736dnk	394	8	,	,	,
cord-321607-3r736dnk	394	9	RIG	rig	NN
cord-321607-3r736dnk	394	10	-	-	:
cord-321607-3r736dnk	394	11	I	I	NNP
cord-321607-3r736dnk	394	12	,	,	,
cord-321607-3r736dnk	394	13	and	and	CC
cord-321607-3r736dnk	394	14	NOD2	NOD2	NNPS
cord-321607-3r736dnk	394	15	are	be	VBP
cord-321607-3r736dnk	394	16	all	all	DT
cord-321607-3r736dnk	394	17	viral	viral	JJ
cord-321607-3r736dnk	394	18	RNA	RNA	NNP
cord-321607-3r736dnk	394	19	sensors	sensor	NNS
cord-321607-3r736dnk	394	20	and	and	CC
cord-321607-3r736dnk	394	21	proximity	proximity	NN
cord-321607-3r736dnk	394	22	to	to	IN
cord-321607-3r736dnk	394	23	viral	viral	JJ
cord-321607-3r736dnk	394	24	entry	entry	NN
cord-321607-3r736dnk	394	25	may	may	MD
cord-321607-3r736dnk	394	26	provide	provide	VB
cord-321607-3r736dnk	394	27	a	a	DT
cord-321607-3r736dnk	394	28	kinetic	kinetic	JJ
cord-321607-3r736dnk	394	29	advantage	advantage	NN
cord-321607-3r736dnk	394	30	to	to	IN
cord-321607-3r736dnk	394	31	the	the	DT
cord-321607-3r736dnk	394	32	cell	cell	NN
cord-321607-3r736dnk	394	33	.	.	.
cord-321607-3r736dnk	395	1	In	in	IN
cord-321607-3r736dnk	395	2	addition	addition	NN
cord-321607-3r736dnk	395	3	,	,	,
cord-321607-3r736dnk	395	4	RIG	rig	NN
cord-321607-3r736dnk	395	5	-	-	:
cord-321607-3r736dnk	395	6	I	i	NN
cord-321607-3r736dnk	395	7	,	,	,
cord-321607-3r736dnk	395	8	RNase	RNase	NNP
cord-321607-3r736dnk	395	9	-	-	HYPH
cord-321607-3r736dnk	395	10	L	L	NNP
cord-321607-3r736dnk	395	11	,	,	,
cord-321607-3r736dnk	395	12	and	and	CC
cord-321607-3r736dnk	395	13	PKR	PKR	NNP
cord-321607-3r736dnk	395	14	have	have	VBP
cord-321607-3r736dnk	395	15	been	be	VBN
cord-321607-3r736dnk	395	16	found	find	VBN
cord-321607-3r736dnk	395	17	to	to	TO
cord-321607-3r736dnk	395	18	associate	associate	VB
cord-321607-3r736dnk	395	19	with	with	IN
cord-321607-3r736dnk	395	20	antiviral	antiviral	JJ
cord-321607-3r736dnk	395	21	stress	stress	NN
cord-321607-3r736dnk	395	22	granules	granule	NNS
cord-321607-3r736dnk	395	23	(	(	-LRB-
cord-321607-3r736dnk	395	24	avSG	avsg	NN
cord-321607-3r736dnk	395	25	)	)	-RRB-
cord-321607-3r736dnk	395	26	that	that	DT
cord-321607-3r736dnk	395	27	form	form	NN
cord-321607-3r736dnk	395	28	after	after	IN
cord-321607-3r736dnk	395	29	virus	virus	NN
cord-321607-3r736dnk	395	30	infection	infection	NN
cord-321607-3r736dnk	395	31	and	and	CC
cord-321607-3r736dnk	395	32	contain	contain	VBP
cord-321607-3r736dnk	395	33	viral	viral	JJ
cord-321607-3r736dnk	395	34	RNA	RNA	NNP
cord-321607-3r736dnk	395	35	.	.	.
cord-321607-3r736dnk	396	1	Formation	formation	NN
cord-321607-3r736dnk	396	2	of	of	IN
cord-321607-3r736dnk	396	3	these	these	DT
cord-321607-3r736dnk	396	4	complexes	complex	NNS
cord-321607-3r736dnk	396	5	is	be	VBZ
cord-321607-3r736dnk	396	6	necessary	necessary	JJ
cord-321607-3r736dnk	396	7	for	for	IN
cord-321607-3r736dnk	396	8	IFNβ	IFNβ	NNS
cord-321607-3r736dnk	396	9	induction	induction	NN
cord-321607-3r736dnk	396	10	in	in	IN
cord-321607-3r736dnk	396	11	response	response	NN
cord-321607-3r736dnk	396	12	to	to	IN
cord-321607-3r736dnk	396	13	multiple	multiple	JJ
cord-321607-3r736dnk	396	14	stimuli	stimulus	NNS
cord-321607-3r736dnk	396	15	[	[	-LRB-
cord-321607-3r736dnk	396	16	154	154	CD
cord-321607-3r736dnk	396	17	,	,	,
cord-321607-3r736dnk	396	18	155	155	CD
cord-321607-3r736dnk	396	19	]	]	-RRB-
cord-321607-3r736dnk	396	20	.	.	.
cord-321607-3r736dnk	397	1	avSGs	avSGs	NNP
cord-321607-3r736dnk	397	2	are	be	VBP
cord-321607-3r736dnk	397	3	related	relate	VBN
cord-321607-3r736dnk	397	4	to	to	IN
cord-321607-3r736dnk	397	5	stress	stress	NN
cord-321607-3r736dnk	397	6	granules	granule	NNS
cord-321607-3r736dnk	397	7	which	which	WDT
cord-321607-3r736dnk	397	8	form	form	VBP
cord-321607-3r736dnk	397	9	during	during	IN
cord-321607-3r736dnk	397	10	cellular	cellular	JJ
cord-321607-3r736dnk	397	11	stress	stress	NN
cord-321607-3r736dnk	397	12	from	from	IN
cord-321607-3r736dnk	397	13	inhibited	inhibited	JJ
cord-321607-3r736dnk	397	14	translation	translation	NN
cord-321607-3r736dnk	397	15	and	and	CC
cord-321607-3r736dnk	397	16	are	be	VBP
cord-321607-3r736dnk	397	17	linked	link	VBN
cord-321607-3r736dnk	397	18	to	to	IN
cord-321607-3r736dnk	397	19	the	the	DT
cord-321607-3r736dnk	397	20	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	397	21	.	.	.
cord-321607-3r736dnk	398	1	If	if	IN
cord-321607-3r736dnk	398	2	avSGs	avsg	NNS
cord-321607-3r736dnk	398	3	are	be	VBP
cord-321607-3r736dnk	398	4	also	also	RB
cord-321607-3r736dnk	398	5	associated	associate	VBN
cord-321607-3r736dnk	398	6	with	with	IN
cord-321607-3r736dnk	398	7	the	the	DT
cord-321607-3r736dnk	398	8	cellular	cellular	JJ
cord-321607-3r736dnk	398	9	structure	structure	NN
cord-321607-3r736dnk	398	10	,	,	,
cord-321607-3r736dnk	398	11	this	this	DT
cord-321607-3r736dnk	398	12	may	may	MD
cord-321607-3r736dnk	398	13	mean	mean	VB
cord-321607-3r736dnk	398	14	that	that	IN
cord-321607-3r736dnk	398	15	RIG	rig	NN
cord-321607-3r736dnk	398	16	-	-	:
cord-321607-3r736dnk	398	17	I	I	NNP
cord-321607-3r736dnk	398	18	,	,	,
cord-321607-3r736dnk	398	19	PKR	PKR	NNP
cord-321607-3r736dnk	398	20	,	,	,
cord-321607-3r736dnk	398	21	and	and	CC
cord-321607-3r736dnk	398	22	RNase	RNase	NNP
cord-321607-3r736dnk	398	23	-	-	HYPH
cord-321607-3r736dnk	398	24	L	L	NNP
cord-321607-3r736dnk	398	25	either	either	CC
cord-321607-3r736dnk	398	26	require	require	VBP
cord-321607-3r736dnk	398	27	their	-PRON-	PRP$
cord-321607-3r736dnk	398	28	interaction	interaction	NN
cord-321607-3r736dnk	398	29	with	with	IN
cord-321607-3r736dnk	398	30	the	the	DT
cord-321607-3r736dnk	398	31	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	398	32	in	in	IN
cord-321607-3r736dnk	398	33	order	order	NN
cord-321607-3r736dnk	398	34	to	to	TO
cord-321607-3r736dnk	398	35	be	be	VB
cord-321607-3r736dnk	398	36	incorporated	incorporate	VBN
cord-321607-3r736dnk	398	37	into	into	IN
cord-321607-3r736dnk	398	38	avSGs	avsgs	CD
cord-321607-3r736dnk	398	39	or	or	CC
cord-321607-3r736dnk	398	40	to	to	TO
cord-321607-3r736dnk	398	41	control	control	VB
cord-321607-3r736dnk	398	42	them	-PRON-	PRP
cord-321607-3r736dnk	398	43	.	.	.
cord-321607-3r736dnk	399	1	Indeed	indeed	RB
cord-321607-3r736dnk	399	2	,	,	,
cord-321607-3r736dnk	399	3	RIG	rig	NN
cord-321607-3r736dnk	399	4	-	-	:
cord-321607-3r736dnk	399	5	I	-PRON-	PRP
cord-321607-3r736dnk	399	6	forms	form	VBZ
cord-321607-3r736dnk	399	7	punctate	punctate	NN
cord-321607-3r736dnk	399	8	domains	domain	NNS
cord-321607-3r736dnk	399	9	when	when	WRB
cord-321607-3r736dnk	399	10	cells	cell	NNS
cord-321607-3r736dnk	399	11	are	be	VBP
cord-321607-3r736dnk	399	12	treated	treat	VBN
cord-321607-3r736dnk	399	13	with	with	IN
cord-321607-3r736dnk	399	14	cytD	cytD	VBG
cord-321607-3r736dnk	399	15	to	to	TO
cord-321607-3r736dnk	399	16	inhibit	inhibit	VB
cord-321607-3r736dnk	399	17	actin	actin	JJ
cord-321607-3r736dnk	399	18	polymerization	polymerization	NN
cord-321607-3r736dnk	399	19	,	,	,
cord-321607-3r736dnk	399	20	however	however	RB
cord-321607-3r736dnk	399	21	it	-PRON-	PRP
cord-321607-3r736dnk	399	22	is	be	VBZ
cord-321607-3r736dnk	399	23	unknown	unknown	JJ
cord-321607-3r736dnk	399	24	whether	whether	IN
cord-321607-3r736dnk	399	25	these	these	DT
cord-321607-3r736dnk	399	26	are	be	VBP
cord-321607-3r736dnk	399	27	avSGs	avsgs	CD
cord-321607-3r736dnk	399	28	.	.	.
cord-321607-3r736dnk	400	1	An	an	DT
cord-321607-3r736dnk	400	2	alternative	alternative	JJ
cord-321607-3r736dnk	400	3	function	function	NN
cord-321607-3r736dnk	400	4	of	of	IN
cord-321607-3r736dnk	400	5	this	this	DT
cord-321607-3r736dnk	400	6	association	association	NN
cord-321607-3r736dnk	400	7	between	between	IN
cord-321607-3r736dnk	400	8	members	member	NNS
cord-321607-3r736dnk	400	9	of	of	IN
cord-321607-3r736dnk	400	10	the	the	DT
cord-321607-3r736dnk	400	11	innate	innate	JJ
cord-321607-3r736dnk	400	12	immune	immune	JJ
cord-321607-3r736dnk	400	13	response	response	NN
cord-321607-3r736dnk	400	14	and	and	CC
cord-321607-3r736dnk	400	15	the	the	DT
cord-321607-3r736dnk	400	16	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	400	17	may	may	MD
cord-321607-3r736dnk	400	18	be	be	VB
cord-321607-3r736dnk	400	19	to	to	TO
cord-321607-3r736dnk	400	20	sequester	sequester	VB
cord-321607-3r736dnk	400	21	these	these	DT
cord-321607-3r736dnk	400	22	proteins	protein	NNS
cord-321607-3r736dnk	400	23	to	to	TO
cord-321607-3r736dnk	400	24	prevent	prevent	VB
cord-321607-3r736dnk	400	25	unintended	unintended	JJ
cord-321607-3r736dnk	400	26	activation	activation	NN
cord-321607-3r736dnk	400	27	.	.	.
cord-321607-3r736dnk	401	1	Incidental	incidental	JJ
cord-321607-3r736dnk	401	2	overexpression	overexpression	NN
cord-321607-3r736dnk	401	3	of	of	IN
cord-321607-3r736dnk	401	4	IFN	IFN	NNP
cord-321607-3r736dnk	401	5	would	would	MD
cord-321607-3r736dnk	401	6	lead	lead	VB
cord-321607-3r736dnk	401	7	to	to	IN
cord-321607-3r736dnk	401	8	the	the	DT
cord-321607-3r736dnk	401	9	needless	needless	JJ
cord-321607-3r736dnk	401	10	upregulation	upregulation	NN
cord-321607-3r736dnk	401	11	of	of	IN
cord-321607-3r736dnk	401	12	hundreds	hundred	NNS
cord-321607-3r736dnk	401	13	of	of	IN
cord-321607-3r736dnk	401	14	genes	gene	NNS
cord-321607-3r736dnk	401	15	and	and	CC
cord-321607-3r736dnk	401	16	create	create	VB
cord-321607-3r736dnk	401	17	an	an	DT
cord-321607-3r736dnk	401	18	unnecessary	unnecessary	JJ
cord-321607-3r736dnk	401	19	heightened	heightened	JJ
cord-321607-3r736dnk	401	20	antiviral	antiviral	JJ
cord-321607-3r736dnk	401	21	state	state	NN
cord-321607-3r736dnk	401	22	in	in	IN
cord-321607-3r736dnk	401	23	surrounding	surround	VBG
cord-321607-3r736dnk	401	24	tissue	tissue	NN
cord-321607-3r736dnk	401	25	.	.	.
cord-321607-3r736dnk	402	1	Similarly	similarly	RB
cord-321607-3r736dnk	402	2	,	,	,
cord-321607-3r736dnk	402	3	RNase	RNase	NNP
cord-321607-3r736dnk	402	4	-	-	HYPH
cord-321607-3r736dnk	402	5	L	L	NNP
cord-321607-3r736dnk	402	6	and	and	CC
cord-321607-3r736dnk	402	7	PKR	PKR	NNP
cord-321607-3r736dnk	402	8	are	be	VBP
cord-321607-3r736dnk	402	9	both	both	DT
cord-321607-3r736dnk	402	10	proapoptotic	proapoptotic	JJ
cord-321607-3r736dnk	402	11	and	and	CC
cord-321607-3r736dnk	402	12	require	require	VB
cord-321607-3r736dnk	402	13	tight	tight	JJ
cord-321607-3r736dnk	402	14	regulation	regulation	NN
cord-321607-3r736dnk	402	15	to	to	TO
cord-321607-3r736dnk	402	16	prevent	prevent	VB
cord-321607-3r736dnk	402	17	accidental	accidental	JJ
cord-321607-3r736dnk	402	18	cell	cell	NN
cord-321607-3r736dnk	402	19	death	death	NN
cord-321607-3r736dnk	402	20	[	[	-LRB-
cord-321607-3r736dnk	402	21	3	3	CD
cord-321607-3r736dnk	402	22	]	]	-RRB-
cord-321607-3r736dnk	402	23	.	.	.
cord-321607-3r736dnk	403	1	The	the	DT
cord-321607-3r736dnk	403	2	question	question	NN
cord-321607-3r736dnk	403	3	that	that	WDT
cord-321607-3r736dnk	403	4	ultimately	ultimately	RB
cord-321607-3r736dnk	403	5	arises	arise	VBZ
cord-321607-3r736dnk	403	6	,	,	,
cord-321607-3r736dnk	403	7	however	however	RB
cord-321607-3r736dnk	403	8	,	,	,
cord-321607-3r736dnk	403	9	is	be	VBZ
cord-321607-3r736dnk	403	10	how	how	WRB
cord-321607-3r736dnk	403	11	does	do	VBZ
cord-321607-3r736dnk	403	12	the	the	DT
cord-321607-3r736dnk	403	13	cell	cell	NN
cord-321607-3r736dnk	403	14	distinguish	distinguish	VB
cord-321607-3r736dnk	403	15	between	between	IN
cord-321607-3r736dnk	403	16	pathogen	pathogen	NN
cord-321607-3r736dnk	403	17	-	-	HYPH
cord-321607-3r736dnk	403	18	induced	induce	VBN
cord-321607-3r736dnk	403	19	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	403	20	remodeling	remodeling	NN
cord-321607-3r736dnk	403	21	and	and	CC
cord-321607-3r736dnk	403	22	that	that	IN
cord-321607-3r736dnk	403	23	due	due	IN
cord-321607-3r736dnk	403	24	to	to	IN
cord-321607-3r736dnk	403	25	physiologic	physiologic	JJ
cord-321607-3r736dnk	403	26	cellular	cellular	JJ
cord-321607-3r736dnk	403	27	processes	process	NNS
cord-321607-3r736dnk	403	28	?	?	.
cord-321607-3r736dnk	404	1	Inflammasome	Inflammasome	NNP
cord-321607-3r736dnk	404	2	activation	activation	NN
cord-321607-3r736dnk	404	3	requires	require	VBZ
cord-321607-3r736dnk	404	4	a	a	DT
cord-321607-3r736dnk	404	5	priming	prime	VBG
cord-321607-3r736dnk	404	6	step	step	NN
cord-321607-3r736dnk	404	7	to	to	TO
cord-321607-3r736dnk	404	8	transcriptionally	transcriptionally	RB
cord-321607-3r736dnk	404	9	induce	induce	VB
cord-321607-3r736dnk	404	10	IL-1β	il-1β	NN
cord-321607-3r736dnk	404	11	and	and	CC
cord-321607-3r736dnk	404	12	IL-18	IL-18	NNP
cord-321607-3r736dnk	404	13	which	which	WDT
cord-321607-3r736dnk	404	14	indicates	indicate	VBZ
cord-321607-3r736dnk	404	15	that	that	IN
cord-321607-3r736dnk	404	16	an	an	DT
cord-321607-3r736dnk	404	17	authentic	authentic	JJ
cord-321607-3r736dnk	404	18	PAMP	PAMP	NNP
cord-321607-3r736dnk	404	19	is	be	VBZ
cord-321607-3r736dnk	404	20	required	require	VBN
cord-321607-3r736dnk	404	21	to	to	TO
cord-321607-3r736dnk	404	22	avoid	avoid	VB
cord-321607-3r736dnk	404	23	spurious	spurious	JJ
cord-321607-3r736dnk	404	24	activation	activation	NN
cord-321607-3r736dnk	404	25	.	.	.
cord-321607-3r736dnk	405	1	The	the	DT
cord-321607-3r736dnk	405	2	priming	prime	VBG
cord-321607-3r736dnk	405	3	signal	signal	NN
cord-321607-3r736dnk	405	4	is	be	VBZ
cord-321607-3r736dnk	405	5	typically	typically	RB
cord-321607-3r736dnk	405	6	initiated	initiate	VBN
cord-321607-3r736dnk	405	7	through	through	IN
cord-321607-3r736dnk	405	8	TLR	TLR	NNP
cord-321607-3r736dnk	405	9	engagement	engagement	NN
cord-321607-3r736dnk	405	10	.	.	.
cord-321607-3r736dnk	406	1	This	this	DT
cord-321607-3r736dnk	406	2	upstream	upstream	JJ
cord-321607-3r736dnk	406	3	role	role	NN
cord-321607-3r736dnk	406	4	may	may	MD
cord-321607-3r736dnk	406	5	explain	explain	VB
cord-321607-3r736dnk	406	6	why	why	WRB
cord-321607-3r736dnk	406	7	TLR	TLR	NNP
cord-321607-3r736dnk	406	8	signaling	signal	VBG
cord-321607-3r736dnk	406	9	molecules	molecule	NNS
cord-321607-3r736dnk	406	10	that	that	WDT
cord-321607-3r736dnk	406	11	are	be	VBP
cord-321607-3r736dnk	406	12	activated	activate	VBN
cord-321607-3r736dnk	406	13	by	by	IN
cord-321607-3r736dnk	406	14	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	406	15	perturbations	perturbation	NNS
cord-321607-3r736dnk	406	16	have	have	VBP
cord-321607-3r736dnk	406	17	not	not	RB
cord-321607-3r736dnk	406	18	yet	yet	RB
cord-321607-3r736dnk	406	19	been	be	VBN
cord-321607-3r736dnk	406	20	identified	identify	VBN
cord-321607-3r736dnk	406	21	[	[	-LRB-
cord-321607-3r736dnk	406	22	156	156	CD
cord-321607-3r736dnk	406	23	]	]	-RRB-
cord-321607-3r736dnk	406	24	.	.	.
cord-321607-3r736dnk	407	1	RLR	RLR	NNP
cord-321607-3r736dnk	407	2	activation	activation	NN
cord-321607-3r736dnk	407	3	does	do	VBZ
cord-321607-3r736dnk	407	4	not	not	RB
cord-321607-3r736dnk	407	5	need	need	VB
cord-321607-3r736dnk	407	6	a	a	DT
cord-321607-3r736dnk	407	7	secondary	secondary	JJ
cord-321607-3r736dnk	407	8	stimulus	stimulus	NN
cord-321607-3r736dnk	407	9	and	and	CC
cord-321607-3r736dnk	407	10	therefore	therefore	RB
cord-321607-3r736dnk	407	11	may	may	MD
cord-321607-3r736dnk	407	12	require	require	VB
cord-321607-3r736dnk	407	13	an	an	DT
cord-321607-3r736dnk	407	14	alternative	alternative	JJ
cord-321607-3r736dnk	407	15	mechanism	mechanism	NN
cord-321607-3r736dnk	407	16	for	for	IN
cord-321607-3r736dnk	407	17	differentiating	differentiate	VBG
cord-321607-3r736dnk	407	18	between	between	IN
cord-321607-3r736dnk	407	19	friendly	friendly	JJ
cord-321607-3r736dnk	407	20	and	and	CC
cord-321607-3r736dnk	407	21	foreign	foreign	JJ
cord-321607-3r736dnk	407	22	actin	actin	NN
cord-321607-3r736dnk	407	23	rearrangement	rearrangement	NN
cord-321607-3r736dnk	407	24	.	.	.
cord-321607-3r736dnk	408	1	Collectively	collectively	RB
cord-321607-3r736dnk	408	2	,	,	,
cord-321607-3r736dnk	408	3	this	this	DT
cord-321607-3r736dnk	408	4	emerging	emerge	VBG
cord-321607-3r736dnk	408	5	area	area	NN
cord-321607-3r736dnk	408	6	of	of	IN
cord-321607-3r736dnk	408	7	study	study	NN
cord-321607-3r736dnk	408	8	still	still	RB
cord-321607-3r736dnk	408	9	has	have	VBZ
cord-321607-3r736dnk	408	10	many	many	JJ
cord-321607-3r736dnk	408	11	discoveries	discovery	NNS
cord-321607-3r736dnk	408	12	to	to	TO
cord-321607-3r736dnk	408	13	be	be	VB
cord-321607-3r736dnk	408	14	made	make	VBN
cord-321607-3r736dnk	408	15	and	and	CC
cord-321607-3r736dnk	408	16	questions	question	NNS
cord-321607-3r736dnk	408	17	to	to	TO
cord-321607-3r736dnk	408	18	answer	answer	VB
cord-321607-3r736dnk	408	19	.	.	.
cord-321607-3r736dnk	409	1	Recent	recent	JJ
cord-321607-3r736dnk	409	2	findings	finding	NNS
cord-321607-3r736dnk	409	3	have	have	VBP
cord-321607-3r736dnk	409	4	shown	show	VBN
cord-321607-3r736dnk	409	5	that	that	IN
cord-321607-3r736dnk	409	6	RNase	RNase	NNP
cord-321607-3r736dnk	409	7	-	-	HYPH
cord-321607-3r736dnk	409	8	L	L	NNP
cord-321607-3r736dnk	409	9	is	be	VBZ
cord-321607-3r736dnk	409	10	not	not	RB
cord-321607-3r736dnk	409	11	only	only	RB
cord-321607-3r736dnk	409	12	a	a	DT
cord-321607-3r736dnk	409	13	member	member	NN
cord-321607-3r736dnk	409	14	of	of	IN
cord-321607-3r736dnk	409	15	this	this	DT
cord-321607-3r736dnk	409	16	new	new	JJ
cord-321607-3r736dnk	409	17	class	class	NN
cord-321607-3r736dnk	409	18	of	of	IN
cord-321607-3r736dnk	409	19	host	host	NN
cord-321607-3r736dnk	409	20	defense	defense	NN
cord-321607-3r736dnk	409	21	mechanisms	mechanism	NNS
cord-321607-3r736dnk	409	22	,	,	,
cord-321607-3r736dnk	409	23	but	but	CC
cord-321607-3r736dnk	409	24	may	may	MD
cord-321607-3r736dnk	409	25	do	do	VB
cord-321607-3r736dnk	409	26	so	so	RB
cord-321607-3r736dnk	409	27	on	on	IN
cord-321607-3r736dnk	409	28	multiple	multiple	JJ
cord-321607-3r736dnk	409	29	levels	level	NNS
cord-321607-3r736dnk	409	30	through	through	IN
cord-321607-3r736dnk	409	31	its	-PRON-	PRP$
cord-321607-3r736dnk	409	32	interactions	interaction	NNS
cord-321607-3r736dnk	409	33	with	with	IN
cord-321607-3r736dnk	409	34	filamin	filamin	NNP
cord-321607-3r736dnk	409	35	A	A	NNP
cord-321607-3r736dnk	409	36	,	,	,
cord-321607-3r736dnk	409	37	IQGAP	IQGAP	NNP
cord-321607-3r736dnk	409	38	,	,	,
cord-321607-3r736dnk	409	39	and	and	CC
cord-321607-3r736dnk	409	40	LNX	LNX	NNP
cord-321607-3r736dnk	409	41	.	.	.
cord-321607-3r736dnk	410	1	Despite	despite	IN
cord-321607-3r736dnk	410	2	over	over	IN
cord-321607-3r736dnk	410	3	40	40	CD
cord-321607-3r736dnk	410	4	years	year	NNS
cord-321607-3r736dnk	410	5	of	of	IN
cord-321607-3r736dnk	410	6	research	research	NN
cord-321607-3r736dnk	410	7	,	,	,
cord-321607-3r736dnk	410	8	this	this	DT
cord-321607-3r736dnk	410	9	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	410	10	still	still	RB
cord-321607-3r736dnk	410	11	has	have	VBZ
cord-321607-3r736dnk	410	12	many	many	JJ
cord-321607-3r736dnk	410	13	lessons	lesson	NNS
cord-321607-3r736dnk	410	14	to	to	TO
cord-321607-3r736dnk	410	15	offer	offer	VB
cord-321607-3r736dnk	410	16	and	and	CC
cord-321607-3r736dnk	410	17	may	may	MD
cord-321607-3r736dnk	410	18	be	be	VB
cord-321607-3r736dnk	410	19	a	a	DT
cord-321607-3r736dnk	410	20	key	key	NN
cord-321607-3r736dnk	410	21	to	to	IN
cord-321607-3r736dnk	410	22	helping	help	VBG
cord-321607-3r736dnk	410	23	elucidate	elucidate	VB
cord-321607-3r736dnk	410	24	the	the	DT
cord-321607-3r736dnk	410	25	link	link	NN
cord-321607-3r736dnk	410	26	between	between	IN
cord-321607-3r736dnk	410	27	cytoskeletal	cytoskeletal	JJ
cord-321607-3r736dnk	410	28	integrity	integrity	NN
cord-321607-3r736dnk	410	29	and	and	CC
cord-321607-3r736dnk	410	30	host	host	NN
cord-321607-3r736dnk	410	31	defense	defense	NN
cord-321607-3r736dnk	410	32	.	.	.
cord-321607-3r736dnk	411	1	SOCS-1	SOCS-1	NNP
cord-321607-3r736dnk	411	2	inhibits	inhibit	VBZ
cord-321607-3r736dnk	411	3	expression	expression	NN
cord-321607-3r736dnk	411	4	of	of	IN
cord-321607-3r736dnk	411	5	the	the	DT
cord-321607-3r736dnk	411	6	antiviral	antiviral	JJ
cord-321607-3r736dnk	411	7	proteins	protein	NNS
cord-321607-3r736dnk	411	8	2	2	CD
cord-321607-3r736dnk	411	9	1	1	CD
cord-321607-3r736dnk	411	10	,	,	,
cord-321607-3r736dnk	411	11	5	5	CD
cord-321607-3r736dnk	411	12	1	1	CD
cord-321607-3r736dnk	411	13	-OAS	-oas	ADD
cord-321607-3r736dnk	412	1	and	and	CC
cord-321607-3r736dnk	412	2	MxA	mxa	NN
cord-321607-3r736dnk	412	3	induced	induce	VBN
cord-321607-3r736dnk	412	4	by	by	IN
cord-321607-3r736dnk	412	5	the	the	DT
cord-321607-3r736dnk	412	6	novel	novel	NN
cord-321607-3r736dnk	412	7	interferon	interferon	NN
cord-321607-3r736dnk	412	8	-	-	HYPH
cord-321607-3r736dnk	412	9	λs	λs	JJ
cord-321607-3r736dnk	412	10	IL-28a	IL-28a	NNP
cord-321607-3r736dnk	412	11	and	and	CC
cord-321607-3r736dnk	412	12	IL-29	IL-29	NNP
cord-321607-3r736dnk	412	13	Identification	Identification	NNP
cord-321607-3r736dnk	412	14	of	of	IN
cord-321607-3r736dnk	412	15	genes	gene	NNS
cord-321607-3r736dnk	412	16	differentially	differentially	RB
cord-321607-3r736dnk	412	17	regulated	regulate	VBN
cord-321607-3r736dnk	412	18	by	by	IN
cord-321607-3r736dnk	412	19	interferon	interferon	NN
cord-321607-3r736dnk	412	20	α	α	NNP
cord-321607-3r736dnk	412	21	,	,	,
cord-321607-3r736dnk	412	22	β	β	NN
cord-321607-3r736dnk	412	23	,	,	,
cord-321607-3r736dnk	412	24	or	or	CC
cord-321607-3r736dnk	412	25	γ	γ	NN
cord-321607-3r736dnk	412	26	using	use	VBG
cord-321607-3r736dnk	412	27	oligonucleotide	oligonucleotide	JJ
cord-321607-3r736dnk	412	28	arrays	array	NNS
cord-321607-3r736dnk	412	29	On	on	IN
cord-321607-3r736dnk	412	30	the	the	DT
cord-321607-3r736dnk	412	31	discovery	discovery	NN
cord-321607-3r736dnk	412	32	of	of	IN
cord-321607-3r736dnk	412	33	interferon	interferon	NN
cord-321607-3r736dnk	412	34	-	-	HYPH
cord-321607-3r736dnk	412	35	inducible	inducible	JJ
cord-321607-3r736dnk	412	36	,	,	,
cord-321607-3r736dnk	412	37	double	double	RB
cord-321607-3r736dnk	412	38	-	-	HYPH
cord-321607-3r736dnk	412	39	stranded	strand	VBN
cord-321607-3r736dnk	412	40	RNA	RNA	NNP
cord-321607-3r736dnk	412	41	activated	activate	VBN
cord-321607-3r736dnk	412	42	enzymes	enzyme	NNS
cord-321607-3r736dnk	412	43	:	:	:
cord-321607-3r736dnk	412	44	The	the	DT
cord-321607-3r736dnk	412	45	2	2	CD
cord-321607-3r736dnk	412	46	1	1	CD
cord-321607-3r736dnk	412	47	-5	-5	CD
cord-321607-3r736dnk	412	48	1	1	CD
cord-321607-3r736dnk	412	49	oligoadenylate	oligoadenylate	NNP
cord-321607-3r736dnk	412	50	synthetases	synthetase	NNS
cord-321607-3r736dnk	412	51	and	and	CC
cord-321607-3r736dnk	412	52	the	the	DT
cord-321607-3r736dnk	412	53	protein	protein	NN
cord-321607-3r736dnk	412	54	kinase	kinase	VBZ
cord-321607-3r736dnk	412	55	PKR	PKR	NNP
cord-321607-3r736dnk	412	56	.	.	.
cord-321607-3r736dnk	413	1	Cytokine	Cytokine	NNP
cord-321607-3r736dnk	413	2	Growth	Growth	NNP
cord-321607-3r736dnk	413	3	Factor	Factor	NNP
cord-321607-3r736dnk	413	4	Rev	Rev	NNP
cord-321607-3r736dnk	413	5	Structural	structural	JJ
cord-321607-3r736dnk	413	6	basis	basis	NN
cord-321607-3r736dnk	413	7	for	for	IN
cord-321607-3r736dnk	413	8	recognition	recognition	NN
cord-321607-3r736dnk	413	9	of	of	IN
cord-321607-3r736dnk	413	10	2	2	CD
cord-321607-3r736dnk	413	11	1	1	CD
cord-321607-3r736dnk	413	12	,	,	,
cord-321607-3r736dnk	413	13	5	5	CD
cord-321607-3r736dnk	413	14	1	1	CD
cord-321607-3r736dnk	414	1	-linked	-linked	WDT
cord-321607-3r736dnk	414	2	oligoadenylates	oligoadenylate	NNS
cord-321607-3r736dnk	414	3	by	by	IN
cord-321607-3r736dnk	414	4	human	human	JJ
cord-321607-3r736dnk	414	5	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	415	1	L	L	NNP
cord-321607-3r736dnk	416	1	Interferon	interferon	NN
cord-321607-3r736dnk	416	2	action	action	NN
cord-321607-3r736dnk	416	3	may	may	MD
cord-321607-3r736dnk	416	4	be	be	VB
cord-321607-3r736dnk	416	5	mediated	mediate	VBN
cord-321607-3r736dnk	416	6	by	by	IN
cord-321607-3r736dnk	416	7	activation	activation	NN
cord-321607-3r736dnk	416	8	of	of	IN
cord-321607-3r736dnk	416	9	a	a	DT
cord-321607-3r736dnk	416	10	nuclease	nuclease	NN
cord-321607-3r736dnk	416	11	by	by	IN
cord-321607-3r736dnk	416	12	pppa2	pppa2	NNP
cord-321607-3r736dnk	416	13	1	1	CD
cord-321607-3r736dnk	416	14	p5	p5	NN
cord-321607-3r736dnk	416	15	1	1	CD
cord-321607-3r736dnk	416	16	A2	a2	NN
cord-321607-3r736dnk	416	17	1	1	CD
cord-321607-3r736dnk	416	18	p5	p5	NN
cord-321607-3r736dnk	416	19	1	1	CD
cord-321607-3r736dnk	417	1	A	a	DT
cord-321607-3r736dnk	417	2	Inhibition	inhibition	NN
cord-321607-3r736dnk	417	3	of	of	IN
cord-321607-3r736dnk	417	4	cell	cell	NN
cord-321607-3r736dnk	417	5	-	-	HYPH
cord-321607-3r736dnk	417	6	free	free	JJ
cord-321607-3r736dnk	417	7	protein	protein	NN
cord-321607-3r736dnk	417	8	synthesis	synthesis	NN
cord-321607-3r736dnk	417	9	by	by	IN
cord-321607-3r736dnk	417	10	pppa2	pppa2	NNP
cord-321607-3r736dnk	417	11	1	1	CD
cord-321607-3r736dnk	417	12	p5	p5	NN
cord-321607-3r736dnk	417	13	1	1	CD
cord-321607-3r736dnk	417	14	A2	a2	NN
cord-321607-3r736dnk	417	15	1	1	CD
cord-321607-3r736dnk	417	16	p5	p5	NN
cord-321607-3r736dnk	417	17	1	1	CD
cord-321607-3r736dnk	417	18	A	a	NN
cord-321607-3r736dnk	417	19	:	:	:
cord-321607-3r736dnk	418	1	A	a	DT
cord-321607-3r736dnk	418	2	novel	novel	NN
cord-321607-3r736dnk	418	3	oligonucleotide	oligonucleotide	NN
cord-321607-3r736dnk	418	4	synthesized	synthesize	VBN
cord-321607-3r736dnk	418	5	by	by	IN
cord-321607-3r736dnk	418	6	interferon	interferon	NN
cord-321607-3r736dnk	418	7	-	-	HYPH
cord-321607-3r736dnk	418	8	treated	treat	VBN
cord-321607-3r736dnk	418	9	l	l	NN
cord-321607-3r736dnk	418	10	cell	cell	NN
cord-321607-3r736dnk	418	11	extracts	extract	VBZ
cord-321607-3r736dnk	418	12	Mechanism	Mechanism	NNP
cord-321607-3r736dnk	418	13	of	of	IN
cord-321607-3r736dnk	418	14	interferon	interferon	NN
cord-321607-3r736dnk	418	15	action	action	NN
cord-321607-3r736dnk	418	16	.	.	.
cord-321607-3r736dnk	419	1	Properties	property	NNS
cord-321607-3r736dnk	419	2	of	of	IN
cord-321607-3r736dnk	419	3	an	an	DT
cord-321607-3r736dnk	419	4	interferon	interferon	NN
cord-321607-3r736dnk	419	5	-	-	HYPH
cord-321607-3r736dnk	419	6	mediated	mediate	VBN
cord-321607-3r736dnk	419	7	ribonucleolytic	ribonucleolytic	JJ
cord-321607-3r736dnk	419	8	activity	activity	NN
cord-321607-3r736dnk	419	9	from	from	IN
cord-321607-3r736dnk	419	10	mouse	mouse	NN
cord-321607-3r736dnk	419	11	l929	l929	NNP
cord-321607-3r736dnk	419	12	cells	cell	NNS
cord-321607-3r736dnk	419	13	Synthesis	Synthesis	NNP
cord-321607-3r736dnk	419	14	of	of	IN
cord-321607-3r736dnk	419	15	low	low	JJ
cord-321607-3r736dnk	419	16	molecular	molecular	JJ
cord-321607-3r736dnk	419	17	weight	weight	NN
cord-321607-3r736dnk	419	18	inhibitor	inhibitor	NN
cord-321607-3r736dnk	419	19	of	of	IN
cord-321607-3r736dnk	419	20	protein	protein	NN
cord-321607-3r736dnk	419	21	synthesis	synthesis	NN
cord-321607-3r736dnk	419	22	with	with	IN
cord-321607-3r736dnk	419	23	enzyme	enzyme	NN
cord-321607-3r736dnk	419	24	from	from	IN
cord-321607-3r736dnk	419	25	interferon	interferon	NN
cord-321607-3r736dnk	419	26	-	-	HYPH
cord-321607-3r736dnk	419	27	treated	treat	VBN
cord-321607-3r736dnk	419	28	cells	cell	NNS
cord-321607-3r736dnk	420	1	Interferon	interferon	NN
cord-321607-3r736dnk	420	2	,	,	,
cord-321607-3r736dnk	420	3	double	double	RB
cord-321607-3r736dnk	420	4	-	-	HYPH
cord-321607-3r736dnk	420	5	stranded	strand	VBN
cord-321607-3r736dnk	420	6	RNA	RNA	NNP
cord-321607-3r736dnk	420	7	and	and	CC
cord-321607-3r736dnk	420	8	RNA	RNA	NNP
cord-321607-3r736dnk	420	9	degradation	degradation	NN
cord-321607-3r736dnk	420	10	.	.	.
cord-321607-3r736dnk	421	1	Fractionation	fractionation	NN
cord-321607-3r736dnk	421	2	of	of	IN
cord-321607-3r736dnk	421	3	the	the	DT
cord-321607-3r736dnk	421	4	endonucleaseint	endonucleaseint	NNP
cord-321607-3r736dnk	421	5	system	system	NN
cord-321607-3r736dnk	421	6	into	into	IN
cord-321607-3r736dnk	421	7	two	two	CD
cord-321607-3r736dnk	421	8	macromolecular	macromolecular	JJ
cord-321607-3r736dnk	421	9	components	component	NNS
cord-321607-3r736dnk	421	10	;	;	:
cord-321607-3r736dnk	421	11	role	role	NN
cord-321607-3r736dnk	421	12	of	of	IN
cord-321607-3r736dnk	421	13	a	a	DT
cord-321607-3r736dnk	421	14	small	small	JJ
cord-321607-3r736dnk	421	15	molecule	molecule	NN
cord-321607-3r736dnk	421	16	in	in	IN
cord-321607-3r736dnk	421	17	nuclease	nuclease	NNP
cord-321607-3r736dnk	421	18	activation	activation	NN
cord-321607-3r736dnk	421	19	Expression	expression	NN
cord-321607-3r736dnk	421	20	cloning	cloning	NN
cord-321607-3r736dnk	421	21	of	of	IN
cord-321607-3r736dnk	421	22	2	2	CD
cord-321607-3r736dnk	421	23	-	-	HYPH
cord-321607-3r736dnk	421	24	5A	5a	NN
cord-321607-3r736dnk	421	25	-	-	HYPH
cord-321607-3r736dnk	421	26	dependent	dependent	JJ
cord-321607-3r736dnk	421	27	RNaase	rnaase	NN
cord-321607-3r736dnk	421	28	:	:	:
cord-321607-3r736dnk	422	1	A	a	DT
cord-321607-3r736dnk	422	2	uniquely	uniquely	RB
cord-321607-3r736dnk	422	3	regulated	regulate	VBN
cord-321607-3r736dnk	422	4	mediator	mediator	NN
cord-321607-3r736dnk	422	5	of	of	IN
cord-321607-3r736dnk	422	6	interferon	interferon	NN
cord-321607-3r736dnk	422	7	action	action	NN
cord-321607-3r736dnk	422	8	Germline	Germline	NNP
cord-321607-3r736dnk	422	9	mutations	mutation	NNS
cord-321607-3r736dnk	422	10	in	in	IN
cord-321607-3r736dnk	422	11	the	the	DT
cord-321607-3r736dnk	422	12	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	422	13	L	l	NN
cord-321607-3r736dnk	422	14	gene	gene	NN
cord-321607-3r736dnk	422	15	in	in	IN
cord-321607-3r736dnk	422	16	families	family	NNS
cord-321607-3r736dnk	422	17	showing	show	VBG
cord-321607-3r736dnk	422	18	linkage	linkage	NN
cord-321607-3r736dnk	422	19	with	with	IN
cord-321607-3r736dnk	422	20	HPC1	HPC1	NNP
cord-321607-3r736dnk	423	1	The	the	DT
cord-321607-3r736dnk	423	2	role	role	NN
cord-321607-3r736dnk	423	3	of	of	IN
cord-321607-3r736dnk	423	4	2	2	CD
cord-321607-3r736dnk	423	5	1	1	CD
cord-321607-3r736dnk	423	6	-5	-5	CD
cord-321607-3r736dnk	423	7	1	1	CD
cord-321607-3r736dnk	423	8	oligoadenylate	oligoadenylate	NN
cord-321607-3r736dnk	423	9	-	-	HYPH
cord-321607-3r736dnk	423	10	activated	activate	VBN
cord-321607-3r736dnk	423	11	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	423	12	L	l	NN
cord-321607-3r736dnk	423	13	in	in	IN
cord-321607-3r736dnk	423	14	apoptosis	apoptosis	NN
cord-321607-3r736dnk	423	15	A	a	DT
cord-321607-3r736dnk	423	16	study	study	NN
cord-321607-3r736dnk	423	17	of	of	IN
cord-321607-3r736dnk	423	18	the	the	DT
cord-321607-3r736dnk	423	19	interferon	interferon	NN
cord-321607-3r736dnk	423	20	antiviral	antiviral	JJ
cord-321607-3r736dnk	423	21	mechanism	mechanism	NN
cord-321607-3r736dnk	423	22	:	:	:
cord-321607-3r736dnk	423	23	Apoptosis	apoptosis	NN
cord-321607-3r736dnk	423	24	activation	activation	NN
cord-321607-3r736dnk	423	25	by	by	IN
cord-321607-3r736dnk	423	26	the	the	DT
cord-321607-3r736dnk	423	27	2	2	CD
cord-321607-3r736dnk	423	28	-	-	HYPH
cord-321607-3r736dnk	423	29	5A	5a	CD
cord-321607-3r736dnk	423	30	system	system	NN
cord-321607-3r736dnk	424	1	A	a	DT
cord-321607-3r736dnk	424	2	dominant	dominant	JJ
cord-321607-3r736dnk	424	3	negative	negative	JJ
cord-321607-3r736dnk	424	4	mutant	mutant	NN
cord-321607-3r736dnk	424	5	of	of	IN
cord-321607-3r736dnk	424	6	2	2	CD
cord-321607-3r736dnk	424	7	-	-	HYPH
cord-321607-3r736dnk	424	8	5A	5a	CD
cord-321607-3r736dnk	424	9	-	-	HYPH
cord-321607-3r736dnk	424	10	dependent	dependent	JJ
cord-321607-3r736dnk	424	11	RNase	rnase	NN
cord-321607-3r736dnk	424	12	suppresses	suppress	VBZ
cord-321607-3r736dnk	424	13	antiproliferative	antiproliferative	JJ
cord-321607-3r736dnk	424	14	and	and	CC
cord-321607-3r736dnk	424	15	antiviral	antiviral	JJ
cord-321607-3r736dnk	424	16	effects	effect	NNS
cord-321607-3r736dnk	424	17	of	of	IN
cord-321607-3r736dnk	424	18	interferon	interferon	NN
cord-321607-3r736dnk	425	1	Interferon	interferon	NN
cord-321607-3r736dnk	425	2	action	action	NN
cord-321607-3r736dnk	425	3	and	and	CC
cord-321607-3r736dnk	425	4	apoptosis	apoptosis	NN
cord-321607-3r736dnk	425	5	are	be	VBP
cord-321607-3r736dnk	425	6	defective	defective	JJ
cord-321607-3r736dnk	425	7	in	in	IN
cord-321607-3r736dnk	425	8	mice	mice	NN
cord-321607-3r736dnk	425	9	devoid	devoid	JJ
cord-321607-3r736dnk	425	10	of	of	IN
cord-321607-3r736dnk	425	11	2	2	CD
cord-321607-3r736dnk	425	12	1	1	CD
cord-321607-3r736dnk	425	13	,	,	,
cord-321607-3r736dnk	425	14	5	5	CD
cord-321607-3r736dnk	425	15	1	1	CD
cord-321607-3r736dnk	425	16	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	425	17	-	-	HYPH
cord-321607-3r736dnk	425	18	dependent	dependent	JJ
cord-321607-3r736dnk	425	19	RNase	rnase	NN
cord-321607-3r736dnk	425	20	L	l	NN
cord-321607-3r736dnk	425	21	Ribonuclease	Ribonuclease	NNP
cord-321607-3r736dnk	425	22	L	L	NNP
cord-321607-3r736dnk	425	23	proteolysis	proteolysis	NN
cord-321607-3r736dnk	425	24	in	in	IN
cord-321607-3r736dnk	425	25	peripheral	peripheral	JJ
cord-321607-3r736dnk	425	26	blood	blood	NN
cord-321607-3r736dnk	425	27	mononuclear	mononuclear	NN
cord-321607-3r736dnk	425	28	cells	cell	NNS
cord-321607-3r736dnk	425	29	of	of	IN
cord-321607-3r736dnk	425	30	chronic	chronic	JJ
cord-321607-3r736dnk	425	31	fatigue	fatigue	NN
cord-321607-3r736dnk	425	32	syndrome	syndrome	NN
cord-321607-3r736dnk	425	33	patients	patient	VBZ
cord-321607-3r736dnk	425	34	Characterization	Characterization	NNP
cord-321607-3r736dnk	425	35	of	of	IN
cord-321607-3r736dnk	425	36	a	a	DT
cord-321607-3r736dnk	425	37	2	2	CD
cord-321607-3r736dnk	425	38	1	1	CD
cord-321607-3r736dnk	425	39	,	,	,
cord-321607-3r736dnk	426	1	5	5	CD
cord-321607-3r736dnk	426	2	1	1	CD
cord-321607-3r736dnk	426	3	-oligoadenylate	-oligoadenylate	:
cord-321607-3r736dnk	426	4	(	(	-LRB-
cord-321607-3r736dnk	426	5	2	2	CD
cord-321607-3r736dnk	426	6	-	-	HYPH
cord-321607-3r736dnk	426	7	5A)-dependent	5a)-dependent	NN
cord-321607-3r736dnk	426	8	37-kDa	37-kda	CD
cord-321607-3r736dnk	427	1	RNase	RNase	NNP
cord-321607-3r736dnk	427	2	L	L	NNP
cord-321607-3r736dnk	427	3	:	:	:
cord-321607-3r736dnk	428	1	Azido	Azido	NNP
cord-321607-3r736dnk	428	2	photoaffinity	photoaffinity	NN
cord-321607-3r736dnk	428	3	labeling	labeling	NN
cord-321607-3r736dnk	428	4	and	and	CC
cord-321607-3r736dnk	428	5	2	2	CD
cord-321607-3r736dnk	428	6	-	-	HYPH
cord-321607-3r736dnk	428	7	5A	5a	CD
cord-321607-3r736dnk	428	8	-	-	HYPH
cord-321607-3r736dnk	428	9	dependent	dependent	JJ
cord-321607-3r736dnk	428	10	activation	activation	NN
cord-321607-3r736dnk	428	11	Biochemical	biochemical	JJ
cord-321607-3r736dnk	428	12	evidence	evidence	NN
cord-321607-3r736dnk	428	13	for	for	IN
cord-321607-3r736dnk	428	14	a	a	DT
cord-321607-3r736dnk	428	15	novel	novel	JJ
cord-321607-3r736dnk	428	16	low	low	JJ
cord-321607-3r736dnk	428	17	molecular	molecular	JJ
cord-321607-3r736dnk	428	18	weight	weight	NN
cord-321607-3r736dnk	428	19	2	2	CD
cord-321607-3r736dnk	428	20	-	-	HYPH
cord-321607-3r736dnk	428	21	5A	5a	NN
cord-321607-3r736dnk	428	22	-	-	HYPH
cord-321607-3r736dnk	428	23	dependent	dependent	JJ
cord-321607-3r736dnk	428	24	RNase	RNase	NNP
cord-321607-3r736dnk	428	25	L	l	NN
cord-321607-3r736dnk	428	26	in	in	IN
cord-321607-3r736dnk	428	27	chronic	chronic	JJ
cord-321607-3r736dnk	428	28	fatigue	fatigue	NN
cord-321607-3r736dnk	428	29	syndrome	syndrome	NN
cord-321607-3r736dnk	428	30	Role	role	NN
cord-321607-3r736dnk	428	31	of	of	IN
cord-321607-3r736dnk	428	32	2	2	CD
cord-321607-3r736dnk	428	33	-	-	HYPH
cord-321607-3r736dnk	428	34	5A	5a	CD
cord-321607-3r736dnk	428	35	-	-	HYPH
cord-321607-3r736dnk	428	36	dependent	dependent	JJ
cord-321607-3r736dnk	428	37	RNase	RNase	NNP
cord-321607-3r736dnk	428	38	-	-	HYPH
cord-321607-3r736dnk	428	39	L	l	NN
cord-321607-3r736dnk	428	40	in	in	IN
cord-321607-3r736dnk	428	41	senescence	senescence	NN
cord-321607-3r736dnk	428	42	and	and	CC
cord-321607-3r736dnk	428	43	longevity	longevity	NN
cord-321607-3r736dnk	428	44	Defects	defect	NNS
cord-321607-3r736dnk	428	45	in	in	IN
cord-321607-3r736dnk	428	46	TLR3	TLR3	NNP
cord-321607-3r736dnk	428	47	expression	expression	NN
cord-321607-3r736dnk	428	48	and	and	CC
cord-321607-3r736dnk	428	49	RNase	RNase	NNP
cord-321607-3r736dnk	428	50	L	L	NNP
cord-321607-3r736dnk	428	51	activation	activation	NN
cord-321607-3r736dnk	428	52	lead	lead	NN
cord-321607-3r736dnk	428	53	to	to	IN
cord-321607-3r736dnk	428	54	decreased	decrease	VBN
cord-321607-3r736dnk	428	55	mnsod	mnsod	JJ
cord-321607-3r736dnk	428	56	expression	expression	NN
cord-321607-3r736dnk	428	57	and	and	CC
cord-321607-3r736dnk	428	58	insulin	insulin	NN
cord-321607-3r736dnk	428	59	resistance	resistance	NN
cord-321607-3r736dnk	428	60	in	in	IN
cord-321607-3r736dnk	428	61	muscle	muscle	NN
cord-321607-3r736dnk	428	62	cells	cell	NNS
cord-321607-3r736dnk	428	63	of	of	IN
cord-321607-3r736dnk	428	64	obese	obese	JJ
cord-321607-3r736dnk	428	65	people	people	NNS
cord-321607-3r736dnk	429	1	RNase	RNase	NNP
cord-321607-3r736dnk	429	2	L	L	NNP
cord-321607-3r736dnk	429	3	controls	control	VBZ
cord-321607-3r736dnk	429	4	terminal	terminal	NN
cord-321607-3r736dnk	429	5	adipocyte	adipocyte	NN
cord-321607-3r736dnk	429	6	differentiation	differentiation	NN
cord-321607-3r736dnk	429	7	,	,	,
cord-321607-3r736dnk	429	8	lipids	lipid	NNS
cord-321607-3r736dnk	429	9	storage	storage	NN
cord-321607-3r736dnk	429	10	and	and	CC
cord-321607-3r736dnk	429	11	insulin	insulin	NN
cord-321607-3r736dnk	429	12	sensitivity	sensitivity	NN
cord-321607-3r736dnk	429	13	via	via	IN
cord-321607-3r736dnk	430	1	CHOP10	CHOP10	NNP
cord-321607-3r736dnk	430	2	mRNA	mrna	NN
cord-321607-3r736dnk	430	3	regulation	regulation	NN
cord-321607-3r736dnk	431	1	RNase	RNase	NNP
cord-321607-3r736dnk	431	2	L	L	NNP
cord-321607-3r736dnk	431	3	mediated	mediate	VBD
cord-321607-3r736dnk	431	4	protection	protection	NN
cord-321607-3r736dnk	431	5	from	from	IN
cord-321607-3r736dnk	431	6	virus	virus	NN
cord-321607-3r736dnk	431	7	induced	induce	VBN
cord-321607-3r736dnk	431	8	demyelination	demyelination	NN
cord-321607-3r736dnk	432	1	RNase	RNase	NNP
cord-321607-3r736dnk	432	2	-	-	HYPH
cord-321607-3r736dnk	432	3	L	l	NN
cord-321607-3r736dnk	432	4	deficiency	deficiency	NN
cord-321607-3r736dnk	432	5	exacerbates	exacerbate	VBZ
cord-321607-3r736dnk	432	6	experimental	experimental	JJ
cord-321607-3r736dnk	432	7	colitis	colitis	NN
cord-321607-3r736dnk	432	8	and	and	CC
cord-321607-3r736dnk	432	9	colitis	colitis	NN
cord-321607-3r736dnk	432	10	-	-	HYPH
cord-321607-3r736dnk	432	11	associated	associate	VBN
cord-321607-3r736dnk	432	12	cancer	cancer	NN
cord-321607-3r736dnk	432	13	RNase	rnase	NN
cord-321607-3r736dnk	432	14	L	L	NNP
cord-321607-3r736dnk	432	15	contributes	contribute	VBZ
cord-321607-3r736dnk	432	16	to	to	TO
cord-321607-3r736dnk	432	17	experimentally	experimentally	RB
cord-321607-3r736dnk	432	18	induced	induce	VBN
cord-321607-3r736dnk	432	19	type	type	NN
cord-321607-3r736dnk	432	20	1	1	CD
cord-321607-3r736dnk	432	21	diabetes	diabetes	NN
cord-321607-3r736dnk	432	22	onset	onset	NN
cord-321607-3r736dnk	432	23	in	in	IN
cord-321607-3r736dnk	432	24	mice	mouse	NNS
cord-321607-3r736dnk	433	1	RNase	RNase	NNP
cord-321607-3r736dnk	433	2	-	-	HYPH
cord-321607-3r736dnk	433	3	L	l	NN
cord-321607-3r736dnk	433	4	control	control	NN
cord-321607-3r736dnk	433	5	of	of	IN
cord-321607-3r736dnk	433	6	cellular	cellular	JJ
cord-321607-3r736dnk	433	7	mRNAs	mrnas	CD
cord-321607-3r736dnk	433	8	:	:	:
cord-321607-3r736dnk	434	1	Roles	role	NNS
cord-321607-3r736dnk	434	2	in	in	IN
cord-321607-3r736dnk	434	3	biologic	biologic	JJ
cord-321607-3r736dnk	434	4	functions	function	NNS
cord-321607-3r736dnk	434	5	and	and	CC
cord-321607-3r736dnk	434	6	mechanisms	mechanism	NNS
cord-321607-3r736dnk	434	7	of	of	IN
cord-321607-3r736dnk	434	8	substrate	substrate	NN
cord-321607-3r736dnk	434	9	targeting	target	VBG
cord-321607-3r736dnk	434	10	An	an	DT
cord-321607-3r736dnk	434	11	essential	essential	JJ
cord-321607-3r736dnk	434	12	role	role	NN
cord-321607-3r736dnk	434	13	for	for	IN
cord-321607-3r736dnk	434	14	the	the	DT
cord-321607-3r736dnk	434	15	antiviral	antiviral	JJ
cord-321607-3r736dnk	434	16	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	434	17	,	,	,
cord-321607-3r736dnk	434	18	RNase	RNase	NNP
cord-321607-3r736dnk	434	19	-	-	HYPH
cord-321607-3r736dnk	434	20	L	L	NNP
cord-321607-3r736dnk	434	21	,	,	,
cord-321607-3r736dnk	434	22	in	in	IN
cord-321607-3r736dnk	434	23	antibacterial	antibacterial	JJ
cord-321607-3r736dnk	434	24	immunity	immunity	NN
cord-321607-3r736dnk	434	25	Small	small	JJ
cord-321607-3r736dnk	434	26	self	self	NN
cord-321607-3r736dnk	434	27	-	-	HYPH
cord-321607-3r736dnk	434	28	RNA	rna	NN
cord-321607-3r736dnk	434	29	generated	generate	VBN
cord-321607-3r736dnk	434	30	by	by	IN
cord-321607-3r736dnk	434	31	RNase	RNase	NNP
cord-321607-3r736dnk	434	32	L	L	NNP
cord-321607-3r736dnk	434	33	amplifies	amplify	VBZ
cord-321607-3r736dnk	434	34	antiviral	antiviral	JJ
cord-321607-3r736dnk	434	35	innate	innate	JJ
cord-321607-3r736dnk	434	36	immunity	immunity	NN
cord-321607-3r736dnk	434	37	RNase	RNase	NNP
cord-321607-3r736dnk	434	38	L	L	NNP
cord-321607-3r736dnk	434	39	interacts	interact	VBZ
cord-321607-3r736dnk	434	40	with	with	IN
cord-321607-3r736dnk	434	41	filamin	filamin	NNP
cord-321607-3r736dnk	434	42	a	a	DT
cord-321607-3r736dnk	434	43	to	to	TO
cord-321607-3r736dnk	434	44	regulate	regulate	VB
cord-321607-3r736dnk	434	45	actin	actin	NN
cord-321607-3r736dnk	434	46	dynamics	dynamic	NNS
cord-321607-3r736dnk	434	47	and	and	CC
cord-321607-3r736dnk	434	48	barrier	barrier	NN
cord-321607-3r736dnk	434	49	function	function	NN
cord-321607-3r736dnk	434	50	for	for	IN
cord-321607-3r736dnk	434	51	viral	viral	JJ
cord-321607-3r736dnk	434	52	entry	entry	NN
cord-321607-3r736dnk	435	1	RNase	RNase	NNP
cord-321607-3r736dnk	435	2	L	L	NNP
cord-321607-3r736dnk	435	3	induces	induce	VBZ
cord-321607-3r736dnk	435	4	autophagy	autophagy	NN
cord-321607-3r736dnk	435	5	via	via	IN
cord-321607-3r736dnk	435	6	c	c	NNP
cord-321607-3r736dnk	435	7	-	-	:
cord-321607-3r736dnk	435	8	jun	jun	NNP
cord-321607-3r736dnk	435	9	N	N	NNP
cord-321607-3r736dnk	435	10	-	-	HYPH
cord-321607-3r736dnk	435	11	terminal	terminal	NN
cord-321607-3r736dnk	435	12	kinase	kinase	NN
cord-321607-3r736dnk	435	13	and	and	CC
cord-321607-3r736dnk	435	14	double	double	RB
cord-321607-3r736dnk	435	15	-	-	HYPH
cord-321607-3r736dnk	435	16	stranded	strand	VBN
cord-321607-3r736dnk	435	17	RNA	rna	NN
cord-321607-3r736dnk	435	18	-	-	HYPH
cord-321607-3r736dnk	435	19	dependent	dependent	JJ
cord-321607-3r736dnk	435	20	protein	protein	NN
cord-321607-3r736dnk	435	21	kinase	kinase	NN
cord-321607-3r736dnk	435	22	signaling	signal	VBG
cord-321607-3r736dnk	435	23	pathways	pathway	NNS
cord-321607-3r736dnk	436	1	RNase	RNase	NNP
cord-321607-3r736dnk	436	2	L	L	NNP
cord-321607-3r736dnk	436	3	cleavage	cleavage	NN
cord-321607-3r736dnk	436	4	products	product	NNS
cord-321607-3r736dnk	436	5	promote	promote	VBP
cord-321607-3r736dnk	436	6	switch	switch	VB
cord-321607-3r736dnk	436	7	from	from	IN
cord-321607-3r736dnk	436	8	autophagy	autophagy	NN
cord-321607-3r736dnk	436	9	to	to	IN
cord-321607-3r736dnk	436	10	apoptosis	apoptosis	NN
cord-321607-3r736dnk	436	11	by	by	IN
cord-321607-3r736dnk	436	12	caspase	caspase	NN
cord-321607-3r736dnk	436	13	-	-	HYPH
cord-321607-3r736dnk	436	14	mediated	mediate	VBN
cord-321607-3r736dnk	436	15	cleavage	cleavage	NN
cord-321607-3r736dnk	436	16	of	of	IN
cord-321607-3r736dnk	436	17	beclin-1	beclin-1	DT
cord-321607-3r736dnk	436	18	Skin	skin	NN
cord-321607-3r736dnk	436	19	allograft	allograft	NN
cord-321607-3r736dnk	436	20	rejection	rejection	NN
cord-321607-3r736dnk	436	21	is	be	VBZ
cord-321607-3r736dnk	436	22	suppressed	suppress	VBN
cord-321607-3r736dnk	436	23	in	in	IN
cord-321607-3r736dnk	436	24	mice	mouse	NNS
cord-321607-3r736dnk	436	25	lacking	lack	VBG
cord-321607-3r736dnk	436	26	the	the	DT
cord-321607-3r736dnk	436	27	antiviral	antiviral	JJ
cord-321607-3r736dnk	436	28	enzyme	enzyme	NN
cord-321607-3r736dnk	436	29	,	,	,
cord-321607-3r736dnk	436	30	2	2	CD
cord-321607-3r736dnk	436	31	1	1	CD
cord-321607-3r736dnk	436	32	,	,	,
cord-321607-3r736dnk	436	33	5	5	CD
cord-321607-3r736dnk	436	34	1	1	CD
cord-321607-3r736dnk	437	1	-oligoadenylate	-oligoadenylate	:
cord-321607-3r736dnk	437	2	-	-	HYPH
cord-321607-3r736dnk	437	3	dependent	dependent	JJ
cord-321607-3r736dnk	437	4	RNase	rnase	NN
cord-321607-3r736dnk	437	5	L	L	NNP
cord-321607-3r736dnk	437	6	Lack	Lack	NNP
cord-321607-3r736dnk	437	7	of	of	IN
cord-321607-3r736dnk	437	8	RNase	RNase	NNP
cord-321607-3r736dnk	437	9	L	L	NNP
cord-321607-3r736dnk	437	10	attenuates	attenuate	VBZ
cord-321607-3r736dnk	437	11	macrophage	macrophage	NN
cord-321607-3r736dnk	437	12	functions	function	NNS
cord-321607-3r736dnk	437	13	Interferons	Interferons	NNPS
cord-321607-3r736dnk	437	14	at	at	IN
cord-321607-3r736dnk	437	15	age	age	NN
cord-321607-3r736dnk	437	16	50	50	CD
cord-321607-3r736dnk	437	17	:	:	:
cord-321607-3r736dnk	438	1	Past	past	JJ
cord-321607-3r736dnk	438	2	,	,	,
cord-321607-3r736dnk	438	3	current	current	JJ
cord-321607-3r736dnk	438	4	and	and	CC
cord-321607-3r736dnk	438	5	future	future	JJ
cord-321607-3r736dnk	438	6	impact	impact	NN
cord-321607-3r736dnk	438	7	on	on	IN
cord-321607-3r736dnk	438	8	biomedicine	biomedicine	NN
cord-321607-3r736dnk	439	1	Interferon	interferon	NN
cord-321607-3r736dnk	439	2	-	-	HYPH
cord-321607-3r736dnk	439	3	inducible	inducible	JJ
cord-321607-3r736dnk	439	4	antiviral	antiviral	JJ
cord-321607-3r736dnk	439	5	effectors	effector	NNS
cord-321607-3r736dnk	440	1	The	the	DT
cord-321607-3r736dnk	440	2	human	human	JJ
cord-321607-3r736dnk	440	3	2	2	CD
cord-321607-3r736dnk	440	4	1	1	CD
cord-321607-3r736dnk	440	5	,	,	,
cord-321607-3r736dnk	440	6	5	5	CD
cord-321607-3r736dnk	440	7	1	1	CD
cord-321607-3r736dnk	440	8	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	440	9	synthetase	synthetase	NN
cord-321607-3r736dnk	440	10	family	family	NN
cord-321607-3r736dnk	440	11	:	:	:
cord-321607-3r736dnk	440	12	Interferon	interferon	NN
cord-321607-3r736dnk	440	13	-	-	HYPH
cord-321607-3r736dnk	440	14	induced	induce	VBN
cord-321607-3r736dnk	440	15	proteins	protein	NNS
cord-321607-3r736dnk	440	16	with	with	IN
cord-321607-3r736dnk	440	17	unique	unique	JJ
cord-321607-3r736dnk	440	18	enzymatic	enzymatic	JJ
cord-321607-3r736dnk	440	19	properties	property	NNS
cord-321607-3r736dnk	441	1	The	the	DT
cord-321607-3r736dnk	441	2	human	human	JJ
cord-321607-3r736dnk	441	3	2	2	CD
cord-321607-3r736dnk	441	4	1	1	CD
cord-321607-3r736dnk	441	5	-5	-5	CD
cord-321607-3r736dnk	441	6	1	1	CD
cord-321607-3r736dnk	441	7	oligoadenylate	oligoadenylate	NNP
cord-321607-3r736dnk	441	8	synthetase	synthetase	NNP
cord-321607-3r736dnk	441	9	family	family	NN
cord-321607-3r736dnk	441	10	:	:	:
cord-321607-3r736dnk	442	1	Unique	unique	JJ
cord-321607-3r736dnk	442	2	bond	bond	NN
cord-321607-3r736dnk	442	3	formation	formation	NN
cord-321607-3r736dnk	442	4	Antiviral	antiviral	JJ
cord-321607-3r736dnk	442	5	activity	activity	NN
cord-321607-3r736dnk	442	6	of	of	IN
cord-321607-3r736dnk	442	7	human	human	JJ
cord-321607-3r736dnk	442	8	OASL	OASL	NNP
cord-321607-3r736dnk	442	9	protein	protein	NN
cord-321607-3r736dnk	442	10	is	be	VBZ
cord-321607-3r736dnk	442	11	mediated	mediate	VBN
cord-321607-3r736dnk	442	12	by	by	IN
cord-321607-3r736dnk	442	13	enhancing	enhance	VBG
cord-321607-3r736dnk	442	14	signaling	signal	VBG
cord-321607-3r736dnk	442	15	of	of	IN
cord-321607-3r736dnk	442	16	the	the	DT
cord-321607-3r736dnk	442	17	RIG-	RIG-	NNP
cord-321607-3r736dnk	443	1	I	-PRON-	PRP
cord-321607-3r736dnk	443	2	RNA	RNA	NNP
cord-321607-3r736dnk	443	3	sensor	sensor	NN
cord-321607-3r736dnk	443	4	Activation	Activation	NNP
cord-321607-3r736dnk	443	5	of	of	IN
cord-321607-3r736dnk	443	6	2	2	CD
cord-321607-3r736dnk	443	7	1	1	CD
cord-321607-3r736dnk	443	8	-5	-5	CD
cord-321607-3r736dnk	443	9	1	1	CD
cord-321607-3r736dnk	443	10	oligoadenylate	oligoadenylate	NN
cord-321607-3r736dnk	443	11	synthetase	synthetase	NN
cord-321607-3r736dnk	443	12	by	by	IN
cord-321607-3r736dnk	443	13	single	single	RB
cord-321607-3r736dnk	443	14	-	-	HYPH
cord-321607-3r736dnk	443	15	stranded	stranded	JJ
cord-321607-3r736dnk	443	16	and	and	CC
cord-321607-3r736dnk	443	17	double	double	RB
cord-321607-3r736dnk	443	18	-	-	HYPH
cord-321607-3r736dnk	443	19	stranded	strand	VBN
cord-321607-3r736dnk	443	20	RNA	RNA	NNP
cord-321607-3r736dnk	443	21	aptamers	aptamer	NNS
cord-321607-3r736dnk	443	22	Selection	Selection	NNP
cord-321607-3r736dnk	443	23	and	and	CC
cord-321607-3r736dnk	443	24	cloning	cloning	NN
cord-321607-3r736dnk	443	25	of	of	IN
cord-321607-3r736dnk	443	26	poly(rC)-binding	poly(rC)-binding	NNP
cord-321607-3r736dnk	443	27	protein	protein	NN
cord-321607-3r736dnk	443	28	2	2	CD
cord-321607-3r736dnk	443	29	and	and	CC
cord-321607-3r736dnk	443	30	raf	raf	NNP
cord-321607-3r736dnk	443	31	kinase	kinase	NNP
cord-321607-3r736dnk	443	32	inhibitor	inhibitor	NN
cord-321607-3r736dnk	443	33	protein	protein	NN
cord-321607-3r736dnk	443	34	RNA	RNA	NNP
cord-321607-3r736dnk	443	35	activators	activator	NNS
cord-321607-3r736dnk	443	36	of	of	IN
cord-321607-3r736dnk	443	37	2	2	CD
cord-321607-3r736dnk	443	38	1	1	CD
cord-321607-3r736dnk	443	39	,	,	,
cord-321607-3r736dnk	444	1	5	5	CD
cord-321607-3r736dnk	444	2	1	1	CD
cord-321607-3r736dnk	444	3	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	444	4	synthetase	synthetase	NN
cord-321607-3r736dnk	444	5	from	from	IN
cord-321607-3r736dnk	444	6	prostate	prostate	NN
cord-321607-3r736dnk	444	7	cancer	cancer	NN
cord-321607-3r736dnk	444	8	cells	cell	NNS
cord-321607-3r736dnk	445	1	Heterogeneous	heterogeneous	JJ
cord-321607-3r736dnk	445	2	nuclear	nuclear	JJ
cord-321607-3r736dnk	445	3	RNA	RNA	NNP
cord-321607-3r736dnk	445	4	from	from	IN
cord-321607-3r736dnk	445	5	hairy	hairy	JJ
cord-321607-3r736dnk	445	6	cell	cell	NN
cord-321607-3r736dnk	445	7	leukemia	leukemia	NN
cord-321607-3r736dnk	445	8	patients	patient	NNS
cord-321607-3r736dnk	445	9	activates	activate	VBZ
cord-321607-3r736dnk	445	10	2	2	CD
cord-321607-3r736dnk	445	11	1	1	CD
cord-321607-3r736dnk	445	12	,	,	,
cord-321607-3r736dnk	446	1	5	5	CD
cord-321607-3r736dnk	446	2	1	1	CD
cord-321607-3r736dnk	446	3	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	446	4	synthetase	synthetase	JJ
cord-321607-3r736dnk	446	5	Ribosomal	Ribosomal	NNP
cord-321607-3r736dnk	446	6	protein	protein	NN
cord-321607-3r736dnk	446	7	mRNAs	mrnas	WDT
cord-321607-3r736dnk	446	8	are	be	VBP
cord-321607-3r736dnk	446	9	primary	primary	JJ
cord-321607-3r736dnk	446	10	targets	target	NNS
cord-321607-3r736dnk	446	11	of	of	IN
cord-321607-3r736dnk	446	12	regulation	regulation	NN
cord-321607-3r736dnk	446	13	in	in	IN
cord-321607-3r736dnk	446	14	RNase	RNase	NNP
cord-321607-3r736dnk	446	15	-	-	HYPH
cord-321607-3r736dnk	446	16	L	l	NN
cord-321607-3r736dnk	446	17	-	-	HYPH
cord-321607-3r736dnk	446	18	induced	induce	VBN
cord-321607-3r736dnk	446	19	senescence	senescence	NN
cord-321607-3r736dnk	446	20	Germline	Germline	NNP
cord-321607-3r736dnk	446	21	mutation	mutation	NN
cord-321607-3r736dnk	446	22	in	in	IN
cord-321607-3r736dnk	446	23	RNase	RNase	NNP
cord-321607-3r736dnk	446	24	L	L	NNP
cord-321607-3r736dnk	446	25	predicts	predict	VBZ
cord-321607-3r736dnk	446	26	increased	increased	JJ
cord-321607-3r736dnk	446	27	risk	risk	NN
cord-321607-3r736dnk	446	28	of	of	IN
cord-321607-3r736dnk	446	29	head	head	NN
cord-321607-3r736dnk	446	30	and	and	CC
cord-321607-3r736dnk	446	31	neck	neck	NN
cord-321607-3r736dnk	446	32	,	,	,
cord-321607-3r736dnk	446	33	uterine	uterine	JJ
cord-321607-3r736dnk	446	34	cervix	cervix	NN
cord-321607-3r736dnk	446	35	and	and	CC
cord-321607-3r736dnk	446	36	breast	breast	NN
cord-321607-3r736dnk	446	37	cancer	cancer	NN
cord-321607-3r736dnk	447	1	A	a	DT
cord-321607-3r736dnk	447	2	bipartite	bipartite	JJ
cord-321607-3r736dnk	447	3	model	model	NN
cord-321607-3r736dnk	447	4	of	of	IN
cord-321607-3r736dnk	447	5	2	2	CD
cord-321607-3r736dnk	447	6	-	-	HYPH
cord-321607-3r736dnk	447	7	5A	5a	CD
cord-321607-3r736dnk	447	8	-	-	HYPH
cord-321607-3r736dnk	447	9	dependent	dependent	JJ
cord-321607-3r736dnk	447	10	RNase	RNase	NNP
cord-321607-3r736dnk	447	11	L	l	NN
cord-321607-3r736dnk	447	12	radiobinding	radiobinding	NN
cord-321607-3r736dnk	447	13	and	and	CC
cord-321607-3r736dnk	447	14	hplc	hplc	NNP
cord-321607-3r736dnk	447	15	analysis	analysis	NN
cord-321607-3r736dnk	447	16	of	of	IN
cord-321607-3r736dnk	447	17	2	2	CD
cord-321607-3r736dnk	447	18	-	-	HYPH
cord-321607-3r736dnk	447	19	5A	5a	CD
cord-321607-3r736dnk	447	20	and	and	CC
cord-321607-3r736dnk	447	21	related	related	JJ
cord-321607-3r736dnk	447	22	oligonucleotides	oligonucleotide	NNS
cord-321607-3r736dnk	447	23	from	from	IN
cord-321607-3r736dnk	447	24	intact	intact	JJ
cord-321607-3r736dnk	447	25	cells	cell	NNS
cord-321607-3r736dnk	447	26	Identification	identification	NN
cord-321607-3r736dnk	447	27	of	of	IN
cord-321607-3r736dnk	447	28	2	2	CD
cord-321607-3r736dnk	447	29	1	1	CD
cord-321607-3r736dnk	447	30	-phosphodiesterase	-phosphodiesterase	NNP
cord-321607-3r736dnk	447	31	,	,	,
cord-321607-3r736dnk	447	32	which	which	WDT
cord-321607-3r736dnk	447	33	plays	play	VBZ
cord-321607-3r736dnk	447	34	a	a	DT
cord-321607-3r736dnk	447	35	role	role	NN
cord-321607-3r736dnk	447	36	in	in	IN
cord-321607-3r736dnk	447	37	the	the	DT
cord-321607-3r736dnk	447	38	2	2	CD
cord-321607-3r736dnk	447	39	-	-	HYPH
cord-321607-3r736dnk	447	40	5A	5a	CD
cord-321607-3r736dnk	447	41	system	system	NN
cord-321607-3r736dnk	447	42	regulated	regulate	VBN
cord-321607-3r736dnk	447	43	by	by	IN
cord-321607-3r736dnk	447	44	interferon	interferon	NN
cord-321607-3r736dnk	447	45	Synthesis	Synthesis	NNP
cord-321607-3r736dnk	447	46	,	,	,
cord-321607-3r736dnk	447	47	characterization	characterization	NN
cord-321607-3r736dnk	447	48	and	and	CC
cord-321607-3r736dnk	447	49	properties	property	NNS
cord-321607-3r736dnk	447	50	of	of	IN
cord-321607-3r736dnk	447	51	ppp(A2	ppp(a2	NN
cord-321607-3r736dnk	447	52	1	1	CD
cord-321607-3r736dnk	447	53	p)nApCp	p)nApCp	NNP
cord-321607-3r736dnk	447	54	and	and	CC
cord-321607-3r736dnk	447	55	related	related	JJ
cord-321607-3r736dnk	447	56	high	high	JJ
cord-321607-3r736dnk	447	57	-	-	HYPH
cord-321607-3r736dnk	447	58	specific	specific	JJ
cord-321607-3r736dnk	447	59	-	-	HYPH
cord-321607-3r736dnk	447	60	activity	activity	NN
cord-321607-3r736dnk	447	61	32P	32p	CD
cord-321607-3r736dnk	447	62	-	-	HYPH
cord-321607-3r736dnk	447	63	labelled	label	VBN
cord-321607-3r736dnk	447	64	derivatives	derivative	NNS
cord-321607-3r736dnk	447	65	of	of	IN
cord-321607-3r736dnk	447	66	ppp(A2	ppp(a2	NN
cord-321607-3r736dnk	447	67	1	1	CD
cord-321607-3r736dnk	448	1	p)nA	p)nA	NNP
cord-321607-3r736dnk	449	1	The	the	DT
cord-321607-3r736dnk	449	2	role	role	NN
cord-321607-3r736dnk	449	3	of	of	IN
cord-321607-3r736dnk	449	4	phosphodiesterase	phosphodiesterase	NN
cord-321607-3r736dnk	449	5	12	12	CD
cord-321607-3r736dnk	449	6	(	(	-LRB-
cord-321607-3r736dnk	449	7	PDE12	PDE12	NNP
cord-321607-3r736dnk	449	8	)	)	-RRB-
cord-321607-3r736dnk	449	9	as	as	IN
cord-321607-3r736dnk	449	10	a	a	DT
cord-321607-3r736dnk	449	11	negative	negative	JJ
cord-321607-3r736dnk	449	12	regulator	regulator	NN
cord-321607-3r736dnk	449	13	of	of	IN
cord-321607-3r736dnk	449	14	the	the	DT
cord-321607-3r736dnk	449	15	innate	innate	JJ
cord-321607-3r736dnk	449	16	immune	immune	JJ
cord-321607-3r736dnk	449	17	response	response	NN
cord-321607-3r736dnk	449	18	and	and	CC
cord-321607-3r736dnk	449	19	the	the	DT
cord-321607-3r736dnk	449	20	discovery	discovery	NN
cord-321607-3r736dnk	449	21	of	of	IN
cord-321607-3r736dnk	449	22	antiviral	antiviral	JJ
cord-321607-3r736dnk	449	23	inhibitors	inhibitor	NNS
cord-321607-3r736dnk	449	24	Structure	Structure	NNP
cord-321607-3r736dnk	449	25	of	of	IN
cord-321607-3r736dnk	449	26	human	human	JJ
cord-321607-3r736dnk	449	27	RNase	RNase	NNP
cord-321607-3r736dnk	449	28	L	L	NNP
cord-321607-3r736dnk	449	29	reveals	reveal	VBZ
cord-321607-3r736dnk	449	30	the	the	DT
cord-321607-3r736dnk	449	31	basis	basis	NN
cord-321607-3r736dnk	449	32	for	for	IN
cord-321607-3r736dnk	449	33	regulated	regulate	VBN
cord-321607-3r736dnk	449	34	RNA	RNA	NNP
cord-321607-3r736dnk	449	35	decay	decay	NN
cord-321607-3r736dnk	449	36	in	in	IN
cord-321607-3r736dnk	449	37	the	the	DT
cord-321607-3r736dnk	449	38	IFN	IFN	NNP
cord-321607-3r736dnk	449	39	response	response	NN
cord-321607-3r736dnk	450	1	Innate	innate	JJ
cord-321607-3r736dnk	450	2	immune	immune	JJ
cord-321607-3r736dnk	450	3	messenger	messenger	NN
cord-321607-3r736dnk	450	4	2	2	CD
cord-321607-3r736dnk	450	5	-	-	HYPH
cord-321607-3r736dnk	450	6	5A	5a	CD
cord-321607-3r736dnk	450	7	tethers	tether	NNS
cord-321607-3r736dnk	450	8	human	human	JJ
cord-321607-3r736dnk	450	9	RNase	RNase	NNP
cord-321607-3r736dnk	450	10	L	L	NNP
cord-321607-3r736dnk	450	11	into	into	IN
cord-321607-3r736dnk	450	12	active	active	JJ
cord-321607-3r736dnk	450	13	high	high	JJ
cord-321607-3r736dnk	450	14	-	-	HYPH
cord-321607-3r736dnk	450	15	order	order	NN
cord-321607-3r736dnk	450	16	complexes	complex	NNS
cord-321607-3r736dnk	451	1	Dimeric	dimeric	JJ
cord-321607-3r736dnk	451	2	structure	structure	NN
cord-321607-3r736dnk	451	3	of	of	IN
cord-321607-3r736dnk	451	4	pseudokinase	pseudokinase	NN
cord-321607-3r736dnk	451	5	RNase	RNase	NNP
cord-321607-3r736dnk	451	6	L	L	NNP
cord-321607-3r736dnk	451	7	bound	bind	VBN
cord-321607-3r736dnk	451	8	to	to	IN
cord-321607-3r736dnk	451	9	2	2	CD
cord-321607-3r736dnk	451	10	-	-	HYPH
cord-321607-3r736dnk	451	11	5A	5a	NN
cord-321607-3r736dnk	452	1	reveals	reveal	VBZ
cord-321607-3r736dnk	452	2	a	a	DT
cord-321607-3r736dnk	452	3	basis	basis	NN
cord-321607-3r736dnk	452	4	for	for	IN
cord-321607-3r736dnk	452	5	interferon	interferon	NN
cord-321607-3r736dnk	452	6	-	-	HYPH
cord-321607-3r736dnk	452	7	induced	induce	VBN
cord-321607-3r736dnk	452	8	antiviral	antiviral	JJ
cord-321607-3r736dnk	452	9	activity	activity	NN
cord-321607-3r736dnk	452	10	Interferon	Interferon	NNP
cord-321607-3r736dnk	452	11	action	action	NN
cord-321607-3r736dnk	452	12	:	:	:
cord-321607-3r736dnk	452	13	RNA	rna	NN
cord-321607-3r736dnk	452	14	cleavage	cleavage	NN
cord-321607-3r736dnk	452	15	pattern	pattern	NN
cord-321607-3r736dnk	452	16	of	of	IN
cord-321607-3r736dnk	452	17	a	a	DT
cord-321607-3r736dnk	452	18	(	(	-LRB-
cord-321607-3r736dnk	452	19	2	2	CD
cord-321607-3r736dnk	452	20	1	1	CD
cord-321607-3r736dnk	452	21	-5	-5	CD
cord-321607-3r736dnk	452	22	1	1	CD
cord-321607-3r736dnk	452	23	)	)	-RRB-
cord-321607-3r736dnk	452	24	oligoadenylate	oligoadenylate	NN
cord-321607-3r736dnk	452	25	-	-	HYPH
cord-321607-3r736dnk	452	26	dependent	dependent	JJ
cord-321607-3r736dnk	452	27	endonuclease	endonuclease	NN
cord-321607-3r736dnk	453	1	Interferon	interferon	NN
cord-321607-3r736dnk	453	2	action	action	NN
cord-321607-3r736dnk	453	3	-	-	HYPH
cord-321607-3r736dnk	453	4	Sequence	sequence	NN
cord-321607-3r736dnk	453	5	specificity	specificity	NN
cord-321607-3r736dnk	453	6	of	of	IN
cord-321607-3r736dnk	453	7	the	the	DT
cord-321607-3r736dnk	453	8	ppp(A2	ppp(a2	NN
cord-321607-3r736dnk	453	9	1	1	CD
cord-321607-3r736dnk	453	10	p)nA	p)na	NN
cord-321607-3r736dnk	453	11	-	-	HYPH
cord-321607-3r736dnk	453	12	dependent	dependent	JJ
cord-321607-3r736dnk	453	13	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	453	14	RNase	RNase	NNP
cord-321607-3r736dnk	453	15	L	L	NNP
cord-321607-3r736dnk	453	16	mediates	mediate	VBZ
cord-321607-3r736dnk	453	17	the	the	DT
cord-321607-3r736dnk	453	18	antiviral	antiviral	JJ
cord-321607-3r736dnk	453	19	effect	effect	NN
cord-321607-3r736dnk	453	20	of	of	IN
cord-321607-3r736dnk	453	21	interferon	interferon	NN
cord-321607-3r736dnk	453	22	through	through	IN
cord-321607-3r736dnk	453	23	a	a	DT
cord-321607-3r736dnk	453	24	selective	selective	JJ
cord-321607-3r736dnk	453	25	reduction	reduction	NN
cord-321607-3r736dnk	453	26	in	in	IN
cord-321607-3r736dnk	453	27	viral	viral	JJ
cord-321607-3r736dnk	453	28	RNA	RNA	NNP
cord-321607-3r736dnk	453	29	during	during	IN
cord-321607-3r736dnk	453	30	encephalomyocarditis	encephalomyocarditis	NNP
cord-321607-3r736dnk	453	31	virus	virus	NN
cord-321607-3r736dnk	453	32	infection	infection	NN
cord-321607-3r736dnk	453	33	RNase	RNase	NNP
cord-321607-3r736dnk	453	34	L	L	NNP
cord-321607-3r736dnk	453	35	attenuates	attenuate	VBZ
cord-321607-3r736dnk	453	36	mitogen	mitogen	NN
cord-321607-3r736dnk	453	37	-	-	HYPH
cord-321607-3r736dnk	453	38	stimulated	stimulate	VBN
cord-321607-3r736dnk	453	39	gene	gene	NN
cord-321607-3r736dnk	453	40	expression	expression	NN
cord-321607-3r736dnk	453	41	via	via	IN
cord-321607-3r736dnk	453	42	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	453	43	and	and	CC
cord-321607-3r736dnk	453	44	post	post	JJ
cord-321607-3r736dnk	453	45	-	-	JJ
cord-321607-3r736dnk	453	46	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	453	47	mechanisms	mechanism	NNS
cord-321607-3r736dnk	453	48	to	to	TO
cord-321607-3r736dnk	453	49	limit	limit	VB
cord-321607-3r736dnk	453	50	the	the	DT
cord-321607-3r736dnk	453	51	proliferative	proliferative	JJ
cord-321607-3r736dnk	453	52	response	response	NN
cord-321607-3r736dnk	454	1	A	a	DT
cord-321607-3r736dnk	454	2	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	454	3	signaling	signal	VBG
cord-321607-3r736dnk	454	4	pathway	pathway	NN
cord-321607-3r736dnk	454	5	in	in	IN
cord-321607-3r736dnk	454	6	the	the	DT
cord-321607-3r736dnk	454	7	IFN	IFN	NNP
cord-321607-3r736dnk	454	8	system	system	NN
cord-321607-3r736dnk	454	9	mediated	mediate	VBN
cord-321607-3r736dnk	454	10	by	by	IN
cord-321607-3r736dnk	454	11	2	2	CD
cord-321607-3r736dnk	454	12	1	1	CD
cord-321607-3r736dnk	454	13	-5	-5	CD
cord-321607-3r736dnk	454	14	1	1	CD
cord-321607-3r736dnk	454	15	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	454	16	activation	activation	NN
cord-321607-3r736dnk	454	17	of	of	IN
cord-321607-3r736dnk	454	18	RNase	RNase	NNP
cord-321607-3r736dnk	454	19	L	L	NNP
cord-321607-3r736dnk	454	20	Mapping	Mapping	NNP
cord-321607-3r736dnk	454	21	of	of	IN
cord-321607-3r736dnk	454	22	the	the	DT
cord-321607-3r736dnk	454	23	human	human	JJ
cord-321607-3r736dnk	454	24	RNase	RNase	NNP
cord-321607-3r736dnk	454	25	L	L	NNP
cord-321607-3r736dnk	454	26	promoter	promoter	NN
cord-321607-3r736dnk	454	27	and	and	CC
cord-321607-3r736dnk	454	28	expression	expression	NN
cord-321607-3r736dnk	454	29	in	in	IN
cord-321607-3r736dnk	454	30	cancer	cancer	NN
cord-321607-3r736dnk	454	31	and	and	CC
cord-321607-3r736dnk	454	32	normal	normal	JJ
cord-321607-3r736dnk	454	33	cells	cell	NNS
cord-321607-3r736dnk	454	34	Overexpression	Overexpression	NNP
cord-321607-3r736dnk	454	35	of	of	IN
cord-321607-3r736dnk	454	36	the	the	DT
cord-321607-3r736dnk	454	37	transcription	transcription	NN
cord-321607-3r736dnk	454	38	factor	factor	NN
cord-321607-3r736dnk	455	1	sp1	sp1	NNP
cord-321607-3r736dnk	455	2	activates	activate	VBZ
cord-321607-3r736dnk	455	3	the	the	DT
cord-321607-3r736dnk	455	4	OAS	OAS	NNP
cord-321607-3r736dnk	455	5	-	-	HYPH
cord-321607-3r736dnk	455	6	RNase	RNase	NNP
cord-321607-3r736dnk	455	7	L	L	NNP
cord-321607-3r736dnk	455	8	-	-	HYPH
cord-321607-3r736dnk	455	9	RIG	rig	NN
cord-321607-3r736dnk	455	10	-	-	:
cord-321607-3r736dnk	455	11	I	-PRON-	PRP
cord-321607-3r736dnk	455	12	pathway	pathway	VBP
cord-321607-3r736dnk	455	13	Regulation	regulation	NN
cord-321607-3r736dnk	455	14	of	of	IN
cord-321607-3r736dnk	455	15	human	human	JJ
cord-321607-3r736dnk	455	16	RNase	RNase	NNP
cord-321607-3r736dnk	455	17	-	-	HYPH
cord-321607-3r736dnk	455	18	L	L	NNP
cord-321607-3r736dnk	455	19	by	by	IN
cord-321607-3r736dnk	455	20	the	the	DT
cord-321607-3r736dnk	455	21	mir-29	mir-29	NNP
cord-321607-3r736dnk	455	22	family	family	NN
cord-321607-3r736dnk	456	1	reveals	reveal	VBZ
cord-321607-3r736dnk	456	2	a	a	DT
cord-321607-3r736dnk	456	3	novel	novel	JJ
cord-321607-3r736dnk	456	4	oncogenic	oncogenic	JJ
cord-321607-3r736dnk	456	5	role	role	NN
cord-321607-3r736dnk	456	6	in	in	IN
cord-321607-3r736dnk	456	7	chronic	chronic	JJ
cord-321607-3r736dnk	456	8	myelogenous	myelogenous	NN
cord-321607-3r736dnk	456	9	leukemia	leukemia	NN
cord-321607-3r736dnk	456	10	Post	post	JJ
cord-321607-3r736dnk	456	11	-	-	JJ
cord-321607-3r736dnk	456	12	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	456	13	regulation	regulation	NN
cord-321607-3r736dnk	456	14	of	of	IN
cord-321607-3r736dnk	456	15	RNase	RNase	NNP
cord-321607-3r736dnk	456	16	-	-	HYPH
cord-321607-3r736dnk	456	17	L	l	NN
cord-321607-3r736dnk	456	18	expression	expression	NN
cord-321607-3r736dnk	456	19	is	be	VBZ
cord-321607-3r736dnk	456	20	mediated	mediate	VBN
cord-321607-3r736dnk	456	21	by	by	IN
cord-321607-3r736dnk	456	22	the	the	DT
cord-321607-3r736dnk	456	23	3	3	CD
cord-321607-3r736dnk	456	24	1	1	CD
cord-321607-3r736dnk	456	25	-untranslated	-untranslated	JJ
cord-321607-3r736dnk	456	26	region	region	NN
cord-321607-3r736dnk	456	27	of	of	IN
cord-321607-3r736dnk	456	28	its	-PRON-	PRP$
cord-321607-3r736dnk	456	29	mRNA	mRNA	NNP
cord-321607-3r736dnk	456	30	Posttranscriptional	Posttranscriptional	NNP
cord-321607-3r736dnk	456	31	regulation	regulation	NN
cord-321607-3r736dnk	456	32	of	of	IN
cord-321607-3r736dnk	456	33	cancer	cancer	NN
cord-321607-3r736dnk	456	34	traits	trait	NNS
cord-321607-3r736dnk	456	35	by	by	IN
cord-321607-3r736dnk	456	36	HuR	HuR	NNP
cord-321607-3r736dnk	456	37	Proteasome	Proteasome	NNP
cord-321607-3r736dnk	456	38	-	-	HYPH
cord-321607-3r736dnk	456	39	mediated	mediate	VBN
cord-321607-3r736dnk	456	40	degradation	degradation	NN
cord-321607-3r736dnk	456	41	of	of	IN
cord-321607-3r736dnk	456	42	RNase	RNase	NNP
cord-321607-3r736dnk	456	43	L	L	NNP
cord-321607-3r736dnk	456	44	in	in	IN
cord-321607-3r736dnk	456	45	response	response	NN
cord-321607-3r736dnk	456	46	to	to	IN
cord-321607-3r736dnk	456	47	phorbol-12-myristate-13-acetate	phorbol-12-myristate-13-acetate	NNP
cord-321607-3r736dnk	456	48	(	(	-LRB-
cord-321607-3r736dnk	456	49	PMA	PMA	NNP
cord-321607-3r736dnk	456	50	)	)	-RRB-
cord-321607-3r736dnk	456	51	treatment	treatment	NN
cord-321607-3r736dnk	456	52	of	of	IN
cord-321607-3r736dnk	456	53	mouse	mouse	NN
cord-321607-3r736dnk	456	54	l929	l929	NNP
cord-321607-3r736dnk	456	55	cells	cell	NNS
cord-321607-3r736dnk	457	1	Decreased	decrease	VBN
cord-321607-3r736dnk	458	1	proteasomal	proteasomal	JJ
cord-321607-3r736dnk	458	2	activity	activity	NN
cord-321607-3r736dnk	458	3	causes	cause	VBZ
cord-321607-3r736dnk	458	4	age	age	NN
cord-321607-3r736dnk	458	5	-	-	HYPH
cord-321607-3r736dnk	458	6	related	relate	VBN
cord-321607-3r736dnk	458	7	phenotypes	phenotype	NNS
cord-321607-3r736dnk	458	8	and	and	CC
cord-321607-3r736dnk	458	9	promotes	promote	VBZ
cord-321607-3r736dnk	458	10	the	the	DT
cord-321607-3r736dnk	458	11	development	development	NN
cord-321607-3r736dnk	458	12	of	of	IN
cord-321607-3r736dnk	458	13	metabolic	metabolic	JJ
cord-321607-3r736dnk	458	14	abnormalities	abnormality	NNS
cord-321607-3r736dnk	458	15	Proteomics	Proteomics	NNP
cord-321607-3r736dnk	458	16	-	-	HYPH
cord-321607-3r736dnk	458	17	based	base	VBN
cord-321607-3r736dnk	458	18	identification	identification	NN
cord-321607-3r736dnk	458	19	of	of	IN
cord-321607-3r736dnk	458	20	novel	novel	NN
cord-321607-3r736dnk	458	21	factor	factor	NN
cord-321607-3r736dnk	458	22	inhibiting	inhibit	VBG
cord-321607-3r736dnk	458	23	hypoxia	hypoxia	NN
cord-321607-3r736dnk	458	24	-	-	HYPH
cord-321607-3r736dnk	458	25	inducible	inducible	JJ
cord-321607-3r736dnk	458	26	factor	factor	NN
cord-321607-3r736dnk	458	27	(	(	-LRB-
cord-321607-3r736dnk	458	28	FIH	FIH	NNP
cord-321607-3r736dnk	458	29	)	)	-RRB-
cord-321607-3r736dnk	458	30	substrates	substrate	NNS
cord-321607-3r736dnk	458	31	indicates	indicate	VBZ
cord-321607-3r736dnk	458	32	widespread	widespread	JJ
cord-321607-3r736dnk	458	33	asparaginyl	asparaginyl	NNP
cord-321607-3r736dnk	458	34	hydroxylation	hydroxylation	NN
cord-321607-3r736dnk	458	35	of	of	IN
cord-321607-3r736dnk	458	36	ankyrin	ankyrin	NNP
cord-321607-3r736dnk	458	37	repeat	repeat	NN
cord-321607-3r736dnk	458	38	domain	domain	NN
cord-321607-3r736dnk	458	39	-	-	HYPH
cord-321607-3r736dnk	458	40	containing	contain	VBG
cord-321607-3r736dnk	458	41	proteins	protein	NNS
cord-321607-3r736dnk	458	42	Cloning	clone	VBG
cord-321607-3r736dnk	458	43	and	and	CC
cord-321607-3r736dnk	458	44	characterization	characterization	NN
cord-321607-3r736dnk	458	45	of	of	IN
cord-321607-3r736dnk	458	46	a	a	DT
cord-321607-3r736dnk	458	47	RNase	RNase	NNP
cord-321607-3r736dnk	458	48	L	l	NN
cord-321607-3r736dnk	458	49	inhibitor	inhibitor	NN
cord-321607-3r736dnk	458	50	.	.	.
cord-321607-3r736dnk	459	1	A	a	DT
cord-321607-3r736dnk	459	2	new	new	JJ
cord-321607-3r736dnk	459	3	component	component	NN
cord-321607-3r736dnk	459	4	of	of	IN
cord-321607-3r736dnk	459	5	the	the	DT
cord-321607-3r736dnk	459	6	interferon	interferon	NN
cord-321607-3r736dnk	459	7	-	-	HYPH
cord-321607-3r736dnk	459	8	regulated	regulate	VBN
cord-321607-3r736dnk	459	9	2	2	CD
cord-321607-3r736dnk	459	10	-	-	HYPH
cord-321607-3r736dnk	459	11	5A	5a	NN
cord-321607-3r736dnk	459	12	pathway	pathway	NN
cord-321607-3r736dnk	459	13	The	the	DT
cord-321607-3r736dnk	459	14	essential	essential	JJ
cord-321607-3r736dnk	459	15	ATP	ATP	NNP
cord-321607-3r736dnk	459	16	-	-	HYPH
cord-321607-3r736dnk	459	17	binding	bind	VBG
cord-321607-3r736dnk	459	18	cassette	cassette	NN
cord-321607-3r736dnk	459	19	protein	protein	NN
cord-321607-3r736dnk	459	20	RLI1	RLI1	NNP
cord-321607-3r736dnk	459	21	functions	function	NNS
cord-321607-3r736dnk	459	22	in	in	IN
cord-321607-3r736dnk	459	23	translation	translation	NN
cord-321607-3r736dnk	459	24	by	by	IN
cord-321607-3r736dnk	459	25	promoting	promote	VBG
cord-321607-3r736dnk	459	26	preinitiation	preinitiation	NNP
cord-321607-3r736dnk	459	27	complex	complex	NNP
cord-321607-3r736dnk	459	28	assembly	assembly	NNP
cord-321607-3r736dnk	460	1	The	the	DT
cord-321607-3r736dnk	460	2	iron	iron	NN
cord-321607-3r736dnk	460	3	-	-	HYPH
cord-321607-3r736dnk	460	4	sulphur	sulphur	NN
cord-321607-3r736dnk	460	5	protein	protein	NN
cord-321607-3r736dnk	460	6	RNase	RNase	NNP
cord-321607-3r736dnk	460	7	Linhibitor	Linhibitor	NNP
cord-321607-3r736dnk	460	8	functions	function	NNS
cord-321607-3r736dnk	460	9	in	in	IN
cord-321607-3r736dnk	460	10	translation	translation	NN
cord-321607-3r736dnk	460	11	termination	termination	NN
cord-321607-3r736dnk	460	12	Biogenesis	biogenesis	NN
cord-321607-3r736dnk	460	13	of	of	IN
cord-321607-3r736dnk	460	14	cytosolic	cytosolic	JJ
cord-321607-3r736dnk	460	15	ribosomes	ribosome	NNS
cord-321607-3r736dnk	460	16	requires	require	VBZ
cord-321607-3r736dnk	460	17	the	the	DT
cord-321607-3r736dnk	460	18	essential	essential	JJ
cord-321607-3r736dnk	460	19	iron	iron	NN
cord-321607-3r736dnk	460	20	-	-	HYPH
cord-321607-3r736dnk	460	21	sulphur	sulphur	NN
cord-321607-3r736dnk	460	22	protein	protein	NN
cord-321607-3r736dnk	460	23	RLI1P	RLI1P	NNS
cord-321607-3r736dnk	460	24	and	and	CC
cord-321607-3r736dnk	460	25	mitochondria	mitochondrion	NNS
cord-321607-3r736dnk	461	1	The	the	DT
cord-321607-3r736dnk	461	2	2	2	CD
cord-321607-3r736dnk	461	3	-	-	HYPH
cord-321607-3r736dnk	461	4	5A	5a	CD
cord-321607-3r736dnk	461	5	/	/	SYM
cord-321607-3r736dnk	461	6	RNase	rnase	NN
cord-321607-3r736dnk	461	7	L	L	NNP
cord-321607-3r736dnk	461	8	/	/	SYM
cord-321607-3r736dnk	461	9	RNase	rnase	NN
cord-321607-3r736dnk	461	10	L	L	NNP
cord-321607-3r736dnk	461	11	inhibitor	inhibitor	NN
cord-321607-3r736dnk	461	12	(	(	-LRB-
cord-321607-3r736dnk	461	13	RLI	RLI	NNP
cord-321607-3r736dnk	461	14	)	)	-RRB-
cord-321607-3r736dnk	462	1	[	[	-LRB-
cord-321607-3r736dnk	462	2	correction	correction	NN
cord-321607-3r736dnk	462	3	of	of	IN
cord-321607-3r736dnk	462	4	(	(	-LRB-
cord-321607-3r736dnk	462	5	RNI	RNI	NNP
cord-321607-3r736dnk	462	6	)	)	-RRB-
cord-321607-3r736dnk	462	7	]	]	-RRB-
cord-321607-3r736dnk	463	1	pathway	pathway	NNP
cord-321607-3r736dnk	463	2	regulates	regulate	VBZ
cord-321607-3r736dnk	463	3	mitochondrial	mitochondrial	NN
cord-321607-3r736dnk	463	4	mRNAs	mrnas	CD
cord-321607-3r736dnk	463	5	stability	stability	NN
cord-321607-3r736dnk	463	6	in	in	IN
cord-321607-3r736dnk	463	7	interferon	interferon	NN
cord-321607-3r736dnk	463	8	α	α	NN
cord-321607-3r736dnk	463	9	-	-	HYPH
cord-321607-3r736dnk	463	10	treated	treat	VBN
cord-321607-3r736dnk	463	11	h9	h9	NN
cord-321607-3r736dnk	463	12	cells	cell	NNS
cord-321607-3r736dnk	464	1	HPC1/	HPC1/	NNPS
cord-321607-3r736dnk	465	1	RNase	RNase	NNP
cord-321607-3r736dnk	465	2	L	L	NNP
cord-321607-3r736dnk	465	3	mediates	mediate	VBZ
cord-321607-3r736dnk	465	4	apoptosis	apoptosis	NN
cord-321607-3r736dnk	465	5	of	of	IN
cord-321607-3r736dnk	465	6	prostate	prostate	NN
cord-321607-3r736dnk	465	7	cancer	cancer	NN
cord-321607-3r736dnk	465	8	cells	cell	NNS
cord-321607-3r736dnk	465	9	treated	treat	VBN
cord-321607-3r736dnk	465	10	with	with	IN
cord-321607-3r736dnk	465	11	2	2	CD
cord-321607-3r736dnk	465	12	1	1	CD
cord-321607-3r736dnk	465	13	,	,	,
cord-321607-3r736dnk	465	14	5	5	CD
cord-321607-3r736dnk	465	15	1	1	CD
cord-321607-3r736dnk	465	16	-oligoadenylates	-oligoadenylate	NNS
cord-321607-3r736dnk	465	17	,	,	,
cord-321607-3r736dnk	465	18	topoisomerase	topoisomerase	IN
cord-321607-3r736dnk	465	19	i	i	PRP
cord-321607-3r736dnk	465	20	inhibitors	inhibitor	NNS
cord-321607-3r736dnk	465	21	,	,	,
cord-321607-3r736dnk	465	22	and	and	CC
cord-321607-3r736dnk	465	23	tumor	tumor	NN
cord-321607-3r736dnk	465	24	necrosis	necrosis	NN
cord-321607-3r736dnk	465	25	factor	factor	NN
cord-321607-3r736dnk	465	26	-	-	HYPH
cord-321607-3r736dnk	465	27	related	relate	VBN
cord-321607-3r736dnk	465	28	apoptosis	apoptosis	NN
cord-321607-3r736dnk	465	29	-	-	HYPH
cord-321607-3r736dnk	465	30	inducing	induce	VBG
cord-321607-3r736dnk	465	31	ligand	ligand	NN
cord-321607-3r736dnk	466	1	RNase	RNase	NNP
cord-321607-3r736dnk	466	2	L	L	NNP
cord-321607-3r736dnk	466	3	inhibitor	inhibitor	NN
cord-321607-3r736dnk	466	4	is	be	VBZ
cord-321607-3r736dnk	466	5	induced	induce	VBN
cord-321607-3r736dnk	466	6	during	during	IN
cord-321607-3r736dnk	466	7	human	human	JJ
cord-321607-3r736dnk	466	8	immunodeficiency	immunodeficiency	NN
cord-321607-3r736dnk	466	9	virus	virus	NN
cord-321607-3r736dnk	466	10	type	type	NN
cord-321607-3r736dnk	466	11	1	1	CD
cord-321607-3r736dnk	466	12	infection	infection	NN
cord-321607-3r736dnk	466	13	and	and	CC
cord-321607-3r736dnk	466	14	down	down	RB
cord-321607-3r736dnk	466	15	regulates	regulate	VBZ
cord-321607-3r736dnk	466	16	the	the	DT
cord-321607-3r736dnk	466	17	2	2	CD
cord-321607-3r736dnk	466	18	-	-	HYPH
cord-321607-3r736dnk	466	19	5A	5a	CD
cord-321607-3r736dnk	466	20	/	/	SYM
cord-321607-3r736dnk	466	21	RNase	rnase	NN
cord-321607-3r736dnk	466	22	L	L	NNP
cord-321607-3r736dnk	466	23	pathway	pathway	NN
cord-321607-3r736dnk	466	24	in	in	IN
cord-321607-3r736dnk	466	25	human	human	JJ
cord-321607-3r736dnk	466	26	T	t	NN
cord-321607-3r736dnk	466	27	cells	cell	NNS
cord-321607-3r736dnk	466	28	RNase	RNase	NNP
cord-321607-3r736dnk	466	29	L	l	NN
cord-321607-3r736dnk	466	30	inhibitor	inhibitor	NN
cord-321607-3r736dnk	466	31	(	(	-LRB-
cord-321607-3r736dnk	466	32	RLI	RLI	NNP
cord-321607-3r736dnk	466	33	)	)	-RRB-
cord-321607-3r736dnk	466	34	antisense	antisense	NN
cord-321607-3r736dnk	466	35	constructions	construction	NNS
cord-321607-3r736dnk	466	36	block	block	NN
cord-321607-3r736dnk	466	37	partially	partially	RB
cord-321607-3r736dnk	467	1	the	the	DT
cord-321607-3r736dnk	467	2	down	down	JJ
cord-321607-3r736dnk	467	3	regulation	regulation	NN
cord-321607-3r736dnk	467	4	of	of	IN
cord-321607-3r736dnk	467	5	the	the	DT
cord-321607-3r736dnk	467	6	2	2	CD
cord-321607-3r736dnk	467	7	-	-	HYPH
cord-321607-3r736dnk	467	8	5A	5a	CD
cord-321607-3r736dnk	467	9	/	/	SYM
cord-321607-3r736dnk	467	10	RNase	rnase	NN
cord-321607-3r736dnk	467	11	L	L	NNP
cord-321607-3r736dnk	467	12	pathway	pathway	NN
cord-321607-3r736dnk	467	13	in	in	IN
cord-321607-3r736dnk	467	14	encephalomyocarditisvirus-(EMCV)-infected	encephalomyocarditisvirus-(EMCV)-infected	NNP
cord-321607-3r736dnk	467	15	cells	cell	NNS
cord-321607-3r736dnk	468	1	A	a	DT
cord-321607-3r736dnk	468	2	newly	newly	RB
cord-321607-3r736dnk	468	3	discovered	discover	VBN
cord-321607-3r736dnk	468	4	function	function	NN
cord-321607-3r736dnk	468	5	for	for	IN
cord-321607-3r736dnk	468	6	RNase	RNase	NNP
cord-321607-3r736dnk	468	7	L	L	NNP
cord-321607-3r736dnk	468	8	in	in	IN
cord-321607-3r736dnk	468	9	regulating	regulate	VBG
cord-321607-3r736dnk	468	10	translation	translation	NN
cord-321607-3r736dnk	468	11	termination	termination	NN
cord-321607-3r736dnk	468	12	2	2	CD
cord-321607-3r736dnk	468	13	1	1	CD
cord-321607-3r736dnk	468	14	,	,	,
cord-321607-3r736dnk	469	1	5	5	CD
cord-321607-3r736dnk	469	2	1	1	CD
cord-321607-3r736dnk	469	3	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	469	4	-	-	HYPH
cord-321607-3r736dnk	469	5	dependent	dependent	JJ
cord-321607-3r736dnk	469	6	RNase	rnase	NN
cord-321607-3r736dnk	469	7	L	l	NN
cord-321607-3r736dnk	469	8	is	be	VBZ
cord-321607-3r736dnk	469	9	a	a	DT
cord-321607-3r736dnk	469	10	dimer	dimer	NN
cord-321607-3r736dnk	469	11	of	of	IN
cord-321607-3r736dnk	469	12	regulatory	regulatory	JJ
cord-321607-3r736dnk	469	13	and	and	CC
cord-321607-3r736dnk	469	14	catalytic	catalytic	JJ
cord-321607-3r736dnk	469	15	subunits	subunit	NNS
cord-321607-3r736dnk	469	16	Eukaryotic	eukaryotic	JJ
cord-321607-3r736dnk	469	17	release	release	NN
cord-321607-3r736dnk	469	18	factors	factor	NNS
cord-321607-3r736dnk	469	19	(	(	-LRB-
cord-321607-3r736dnk	469	20	ERFS	ERFS	NNP
cord-321607-3r736dnk	469	21	)	)	-RRB-
cord-321607-3r736dnk	469	22	history	history	NN
cord-321607-3r736dnk	470	1	RNase	RNase	NNP
cord-321607-3r736dnk	470	2	Lregulates	Lregulates	NNP
cord-321607-3r736dnk	470	3	the	the	DT
cord-321607-3r736dnk	470	4	stability	stability	NN
cord-321607-3r736dnk	470	5	of	of	IN
cord-321607-3r736dnk	470	6	mitochondrial	mitochondrial	NN
cord-321607-3r736dnk	471	1	DNA	dna	NN
cord-321607-3r736dnk	471	2	-	-	HYPH
cord-321607-3r736dnk	471	3	encoded	encode	VBN
cord-321607-3r736dnk	471	4	mRNAs	mRNAs	NNPS
cord-321607-3r736dnk	471	5	in	in	IN
cord-321607-3r736dnk	471	6	mouse	mouse	NN
cord-321607-3r736dnk	471	7	embryo	embryo	NN
cord-321607-3r736dnk	471	8	fibroblasts	fibroblast	VBZ
cord-321607-3r736dnk	471	9	Regulation	regulation	NN
cord-321607-3r736dnk	471	10	of	of	IN
cord-321607-3r736dnk	471	11	mitochondrial	mitochondrial	NN
cord-321607-3r736dnk	471	12	mRNA	mrna	NN
cord-321607-3r736dnk	472	1	stability	stability	NN
cord-321607-3r736dnk	472	2	by	by	IN
cord-321607-3r736dnk	472	3	RNase	RNase	NNP
cord-321607-3r736dnk	472	4	L	L	NNP
cord-321607-3r736dnk	472	5	is	be	VBZ
cord-321607-3r736dnk	472	6	translation	translation	NN
cord-321607-3r736dnk	472	7	-	-	HYPH
cord-321607-3r736dnk	472	8	dependent	dependent	JJ
cord-321607-3r736dnk	472	9	and	and	CC
cord-321607-3r736dnk	472	10	controls	control	NNS
cord-321607-3r736dnk	473	1	IFNα	IFNα	NNP
cord-321607-3r736dnk	473	2	-	-	HYPH
cord-321607-3r736dnk	473	3	induced	induce	VBN
cord-321607-3r736dnk	473	4	apoptosis	apoptosis	NN
cord-321607-3r736dnk	473	5	Ultrastructural	Ultrastructural	NNP
cord-321607-3r736dnk	473	6	localization	localization	NN
cord-321607-3r736dnk	473	7	of	of	IN
cord-321607-3r736dnk	473	8	interferon	interferon	NN
cord-321607-3r736dnk	473	9	-	-	HYPH
cord-321607-3r736dnk	473	10	inducible	inducible	JJ
cord-321607-3r736dnk	473	11	double	double	RB
cord-321607-3r736dnk	473	12	-	-	HYPH
cord-321607-3r736dnk	473	13	stranded	strand	VBN
cord-321607-3r736dnk	473	14	RNA	RNA	NNP
cord-321607-3r736dnk	473	15	-	-	HYPH
cord-321607-3r736dnk	473	16	activated	activate	VBN
cord-321607-3r736dnk	473	17	enzymes	enzyme	NNS
cord-321607-3r736dnk	473	18	in	in	IN
cord-321607-3r736dnk	473	19	human	human	JJ
cord-321607-3r736dnk	473	20	cells	cell	NNS
cord-321607-3r736dnk	474	1	Human	human	NN
cord-321607-3r736dnk	475	1	2	2	CD
cord-321607-3r736dnk	475	2	1	1	CD
cord-321607-3r736dnk	475	3	-phosphodiesterase	-phosphodiesterase	NN
cord-321607-3r736dnk	475	4	localizes	localize	VBZ
cord-321607-3r736dnk	475	5	to	to	IN
cord-321607-3r736dnk	475	6	the	the	DT
cord-321607-3r736dnk	475	7	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	475	8	matrix	matrix	NN
cord-321607-3r736dnk	475	9	with	with	IN
cord-321607-3r736dnk	475	10	a	a	DT
cord-321607-3r736dnk	475	11	putative	putative	JJ
cord-321607-3r736dnk	475	12	function	function	NN
cord-321607-3r736dnk	475	13	in	in	IN
cord-321607-3r736dnk	475	14	mitochondrial	mitochondrial	JJ
cord-321607-3r736dnk	475	15	RNA	RNA	NNP
cord-321607-3r736dnk	475	16	turnover	turnover	NN
cord-321607-3r736dnk	476	1	The	the	DT
cord-321607-3r736dnk	476	2	mRNA	mrna	NN
cord-321607-3r736dnk	476	3	-	-	HYPH
cord-321607-3r736dnk	476	4	destabilizing	destabilize	VBG
cord-321607-3r736dnk	476	5	protein	protein	NN
cord-321607-3r736dnk	476	6	tristetraprolin	tristetraprolin	NN
cord-321607-3r736dnk	476	7	is	be	VBZ
cord-321607-3r736dnk	476	8	suppressed	suppress	VBN
cord-321607-3r736dnk	476	9	in	in	IN
cord-321607-3r736dnk	476	10	many	many	JJ
cord-321607-3r736dnk	476	11	cancers	cancer	NNS
cord-321607-3r736dnk	476	12	,	,	,
cord-321607-3r736dnk	476	13	altering	alter	VBG
cord-321607-3r736dnk	476	14	tumorigenic	tumorigenic	JJ
cord-321607-3r736dnk	476	15	phenotypes	phenotype	NNS
cord-321607-3r736dnk	476	16	and	and	CC
cord-321607-3r736dnk	476	17	patient	patient	JJ
cord-321607-3r736dnk	476	18	prognosis	prognosis	NN
cord-321607-3r736dnk	476	19	TTP	TTP	NNP
cord-321607-3r736dnk	476	20	)	)	-RRB-
cord-321607-3r736dnk	477	1	:	:	:
cord-321607-3r736dnk	477	2	Interactions	interaction	NNS
cord-321607-3r736dnk	477	3	with	with	IN
cord-321607-3r736dnk	477	4	mRNA	mrna	NN
cord-321607-3r736dnk	477	5	and	and	CC
cord-321607-3r736dnk	477	6	proteins	protein	NNS
cord-321607-3r736dnk	477	7	,	,	,
cord-321607-3r736dnk	477	8	and	and	CC
cord-321607-3r736dnk	477	9	current	current	JJ
cord-321607-3r736dnk	477	10	thoughts	thought	NNS
cord-321607-3r736dnk	477	11	on	on	IN
cord-321607-3r736dnk	477	12	mechanisms	mechanism	NNS
cord-321607-3r736dnk	477	13	of	of	IN
cord-321607-3r736dnk	477	14	action	action	NN
cord-321607-3r736dnk	477	15	Zinc	zinc	NN
cord-321607-3r736dnk	477	16	-	-	HYPH
cord-321607-3r736dnk	477	17	finger	finger	NN
cord-321607-3r736dnk	477	18	antiviral	antiviral	JJ
cord-321607-3r736dnk	477	19	protein	protein	NN
cord-321607-3r736dnk	477	20	mediates	mediate	VBZ
cord-321607-3r736dnk	477	21	retinoic	retinoic	JJ
cord-321607-3r736dnk	477	22	acid	acid	NN
cord-321607-3r736dnk	477	23	inducible	inducible	JJ
cord-321607-3r736dnk	477	24	gene	gene	NN
cord-321607-3r736dnk	477	25	I	I	NNP
cord-321607-3r736dnk	477	26	-	-	HYPH
cord-321607-3r736dnk	477	27	like	like	JJ
cord-321607-3r736dnk	477	28	receptor	receptor	NN
cord-321607-3r736dnk	477	29	-	-	HYPH
cord-321607-3r736dnk	477	30	independent	independent	JJ
cord-321607-3r736dnk	477	31	antiviral	antiviral	JJ
cord-321607-3r736dnk	477	32	response	response	NN
cord-321607-3r736dnk	477	33	to	to	IN
cord-321607-3r736dnk	477	34	murine	murine	JJ
cord-321607-3r736dnk	477	35	leukemia	leukemia	NN
cord-321607-3r736dnk	477	36	virus	virus	NN
cord-321607-3r736dnk	478	1	mRNA	mRNA	NNP
cord-321607-3r736dnk	478	2	degradation	degradation	NN
cord-321607-3r736dnk	478	3	by	by	IN
cord-321607-3r736dnk	478	4	the	the	DT
cord-321607-3r736dnk	478	5	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	479	1	Regnase-1	Regnase-1	NNP
cord-321607-3r736dnk	479	2	/	/	SYM
cord-321607-3r736dnk	479	3	ZC3H12a	ZC3H12a	NNS
cord-321607-3r736dnk	479	4	/	/	SYM
cord-321607-3r736dnk	479	5	MCPIP-1	MCPIP-1	NNS
cord-321607-3r736dnk	480	1	RNase	RNase	NNP
cord-321607-3r736dnk	480	2	L	L	NNP
cord-321607-3r736dnk	480	3	activates	activate	VBZ
cord-321607-3r736dnk	480	4	the	the	DT
cord-321607-3r736dnk	480	5	NLRP3	nlrp3	XX
cord-321607-3r736dnk	480	6	inflammasome	inflammasome	NN
cord-321607-3r736dnk	480	7	during	during	IN
cord-321607-3r736dnk	480	8	viral	viral	JJ
cord-321607-3r736dnk	480	9	infections	infection	NNS
cord-321607-3r736dnk	480	10	Enteropathogenic	Enteropathogenic	NNP
cord-321607-3r736dnk	480	11	escherichia	escherichia	NN
cord-321607-3r736dnk	480	12	coli	coli	NNS
cord-321607-3r736dnk	481	1	inhibits	inhibit	VBZ
cord-321607-3r736dnk	481	2	type	type	NN
cord-321607-3r736dnk	481	3	I	-PRON-	PRP
cord-321607-3r736dnk	481	4	interferon	interferon	NN
cord-321607-3r736dnk	481	5	-	-	:
cord-321607-3r736dnk	481	6	and	and	CC
cord-321607-3r736dnk	481	7	RNase	RNase	NNP
cord-321607-3r736dnk	481	8	L	l	NN
cord-321607-3r736dnk	481	9	-	-	HYPH
cord-321607-3r736dnk	481	10	mediated	mediate	VBN
cord-321607-3r736dnk	481	11	host	host	NN
cord-321607-3r736dnk	481	12	defense	defense	NN
cord-321607-3r736dnk	481	13	to	to	TO
cord-321607-3r736dnk	481	14	disrupt	disrupt	VB
cord-321607-3r736dnk	481	15	intestinal	intestinal	JJ
cord-321607-3r736dnk	481	16	epithelial	epithelial	JJ
cord-321607-3r736dnk	481	17	cell	cell	NN
cord-321607-3r736dnk	481	18	barrier	barrier	NN
cord-321607-3r736dnk	481	19	function	function	NN
cord-321607-3r736dnk	482	1	Viral	viral	JJ
cord-321607-3r736dnk	482	2	encounters	encounter	VBZ
cord-321607-3r736dnk	482	3	with	with	IN
cord-321607-3r736dnk	482	4	2	2	CD
cord-321607-3r736dnk	482	5	1	1	CD
cord-321607-3r736dnk	482	6	,	,	,
cord-321607-3r736dnk	482	7	5	5	CD
cord-321607-3r736dnk	482	8	1	1	CD
cord-321607-3r736dnk	482	9	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	482	10	synthetase	synthetase	NN
cord-321607-3r736dnk	482	11	and	and	CC
cord-321607-3r736dnk	482	12	RNase	RNase	NNP
cord-321607-3r736dnk	482	13	L	L	NNP
cord-321607-3r736dnk	482	14	during	during	IN
cord-321607-3r736dnk	482	15	the	the	DT
cord-321607-3r736dnk	482	16	interferon	interferon	NN
cord-321607-3r736dnk	482	17	antiviral	antiviral	JJ
cord-321607-3r736dnk	482	18	response	response	NN
cord-321607-3r736dnk	483	1	Interferon	interferon	NN
cord-321607-3r736dnk	483	2	action	action	NN
cord-321607-3r736dnk	483	3	:	:	:
cord-321607-3r736dnk	483	4	Binding	binding	NN
cord-321607-3r736dnk	483	5	of	of	IN
cord-321607-3r736dnk	483	6	viral	viral	JJ
cord-321607-3r736dnk	483	7	RNA	RNA	NNP
cord-321607-3r736dnk	483	8	to	to	IN
cord-321607-3r736dnk	483	9	the	the	DT
cord-321607-3r736dnk	483	10	40-kilodalton	40-kilodalton	CD
cord-321607-3r736dnk	483	11	2	2	CD
cord-321607-3r736dnk	483	12	1	1	CD
cord-321607-3r736dnk	483	13	-5	-5	CD
cord-321607-3r736dnk	483	14	1	1	CD
cord-321607-3r736dnk	483	15	-oligoadenylate	-oligoadenylate	NN
cord-321607-3r736dnk	483	16	synthetase	synthetase	NN
cord-321607-3r736dnk	483	17	in	in	IN
cord-321607-3r736dnk	483	18	interferon	interferon	NN
cord-321607-3r736dnk	483	19	-	-	HYPH
cord-321607-3r736dnk	483	20	treated	treat	VBN
cord-321607-3r736dnk	483	21	hela	hela	NNP
cord-321607-3r736dnk	483	22	cells	cell	NNS
cord-321607-3r736dnk	483	23	infected	infect	VBN
cord-321607-3r736dnk	483	24	with	with	IN
cord-321607-3r736dnk	483	25	encephalomyocarditis	encephalomyocarditis	NNP
cord-321607-3r736dnk	483	26	virus	virus	NN
cord-321607-3r736dnk	483	27	Natural	natural	JJ
cord-321607-3r736dnk	483	28	occurrence	occurrence	NN
cord-321607-3r736dnk	483	29	of	of	IN
cord-321607-3r736dnk	483	30	2	2	CD
cord-321607-3r736dnk	483	31	-	-	HYPH
cord-321607-3r736dnk	483	32	5A	5a	NN
cord-321607-3r736dnk	483	33	in	in	IN
cord-321607-3r736dnk	483	34	interferon	interferon	NN
cord-321607-3r736dnk	483	35	-	-	HYPH
cord-321607-3r736dnk	483	36	treated	treat	VBN
cord-321607-3r736dnk	483	37	emc	emc	NNP
cord-321607-3r736dnk	483	38	virus	virus	NN
cord-321607-3r736dnk	483	39	-	-	HYPH
cord-321607-3r736dnk	483	40	infected	infect	VBN
cord-321607-3r736dnk	483	41	l	l	NN
cord-321607-3r736dnk	483	42	cells	cell	NNS
cord-321607-3r736dnk	484	1	A	a	DT
cord-321607-3r736dnk	484	2	phylogenetically	phylogenetically	RB
cord-321607-3r736dnk	484	3	conserved	conserve	VBN
cord-321607-3r736dnk	484	4	RNA	RNA	NNP
cord-321607-3r736dnk	484	5	structure	structure	NN
cord-321607-3r736dnk	484	6	in	in	IN
cord-321607-3r736dnk	484	7	the	the	DT
cord-321607-3r736dnk	484	8	poliovirus	poliovirus	NN
cord-321607-3r736dnk	484	9	open	open	JJ
cord-321607-3r736dnk	484	10	reading	reading	NN
cord-321607-3r736dnk	484	11	frame	frame	NN
cord-321607-3r736dnk	484	12	inhibits	inhibit	VBZ
cord-321607-3r736dnk	484	13	the	the	DT
cord-321607-3r736dnk	484	14	antiviral	antiviral	JJ
cord-321607-3r736dnk	484	15	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	485	1	RNase	RNase	NNP
cord-321607-3r736dnk	485	2	L	L	NNP
cord-321607-3r736dnk	485	3	Evasion	evasion	NN
cord-321607-3r736dnk	485	4	of	of	IN
cord-321607-3r736dnk	485	5	antiviral	antiviral	JJ
cord-321607-3r736dnk	485	6	innate	innate	JJ
cord-321607-3r736dnk	485	7	immunity	immunity	NN
cord-321607-3r736dnk	485	8	by	by	IN
cord-321607-3r736dnk	485	9	theiler	theiler	NNP
cord-321607-3r736dnk	485	10	's	's	POS
cord-321607-3r736dnk	485	11	virus	virus	NN
cord-321607-3r736dnk	485	12	l	l	NN
cord-321607-3r736dnk	485	13	*	*	NFP
cord-321607-3r736dnk	485	14	protein	protein	NN
cord-321607-3r736dnk	485	15	through	through	IN
cord-321607-3r736dnk	485	16	direct	direct	JJ
cord-321607-3r736dnk	485	17	inhibition	inhibition	NN
cord-321607-3r736dnk	485	18	of	of	IN
cord-321607-3r736dnk	485	19	RNase	RNase	NNP
cord-321607-3r736dnk	485	20	L	L	NNP
cord-321607-3r736dnk	485	21	A	A	NNP
cord-321607-3r736dnk	485	22	viral	viral	JJ
cord-321607-3r736dnk	485	23	RNA	rna	NN
cord-321607-3r736dnk	485	24	competitively	competitively	RB
cord-321607-3r736dnk	485	25	inhibits	inhibit	VBZ
cord-321607-3r736dnk	485	26	the	the	DT
cord-321607-3r736dnk	485	27	antiviral	antiviral	JJ
cord-321607-3r736dnk	485	28	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	485	29	domain	domain	NN
cord-321607-3r736dnk	485	30	of	of	IN
cord-321607-3r736dnk	485	31	RNase	RNase	NNP
cord-321607-3r736dnk	485	32	L	L	NNP
cord-321607-3r736dnk	485	33	A	A	NNP
cord-321607-3r736dnk	485	34	putative	putative	JJ
cord-321607-3r736dnk	485	35	loop	loop	NN
cord-321607-3r736dnk	485	36	E	e	NN
cord-321607-3r736dnk	485	37	motif	motif	NN
cord-321607-3r736dnk	485	38	and	and	CC
cord-321607-3r736dnk	485	39	an	an	DT
cord-321607-3r736dnk	485	40	H	h	NN
cord-321607-3r736dnk	485	41	-	-	HYPH
cord-321607-3r736dnk	485	42	H	h	NN
cord-321607-3r736dnk	485	43	kissing	kissing	NN
cord-321607-3r736dnk	485	44	loop	loop	NN
cord-321607-3r736dnk	485	45	interaction	interaction	NN
cord-321607-3r736dnk	485	46	are	be	VBP
cord-321607-3r736dnk	485	47	conserved	conserve	VBN
cord-321607-3r736dnk	485	48	and	and	CC
cord-321607-3r736dnk	485	49	functional	functional	JJ
cord-321607-3r736dnk	485	50	features	feature	NNS
cord-321607-3r736dnk	485	51	in	in	IN
cord-321607-3r736dnk	485	52	a	a	DT
cord-321607-3r736dnk	485	53	group	group	NN
cord-321607-3r736dnk	485	54	C	C	NNP
cord-321607-3r736dnk	485	55	enterovirus	enterovirus	NN
cord-321607-3r736dnk	485	56	RNA	RNA	NNP
cord-321607-3r736dnk	485	57	that	that	WDT
cord-321607-3r736dnk	485	58	inhibits	inhibit	VBZ
cord-321607-3r736dnk	485	59	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	485	60	L	L	NNP
cord-321607-3r736dnk	485	61	Activation	Activation	NNP
cord-321607-3r736dnk	485	62	and	and	CC
cord-321607-3r736dnk	485	63	evasion	evasion	NN
cord-321607-3r736dnk	485	64	of	of	IN
cord-321607-3r736dnk	485	65	the	the	DT
cord-321607-3r736dnk	485	66	antiviral	antiviral	JJ
cord-321607-3r736dnk	485	67	2	2	CD
cord-321607-3r736dnk	485	68	1	1	CD
cord-321607-3r736dnk	485	69	-5	-5	CD
cord-321607-3r736dnk	485	70	1	1	CD
cord-321607-3r736dnk	485	71	oligoadenylate	oligoadenylate	NNP
cord-321607-3r736dnk	485	72	synthetase	synthetase	NN
cord-321607-3r736dnk	485	73	/	/	SYM
cord-321607-3r736dnk	485	74	ribonuclease	ribonuclease	NN
cord-321607-3r736dnk	485	75	L	L	NNP
cord-321607-3r736dnk	485	76	pathway	pathway	NN
cord-321607-3r736dnk	485	77	by	by	IN
cord-321607-3r736dnk	485	78	hepatitis	hepatitis	NNP
cord-321607-3r736dnk	485	79	c	c	NNP
cord-321607-3r736dnk	485	80	virus	virus	NN
cord-321607-3r736dnk	486	1	mRNA	mRNA	NNP
cord-321607-3r736dnk	486	2	Hepatitis	Hepatitis	NNP
cord-321607-3r736dnk	486	3	c	c	NNP
cord-321607-3r736dnk	486	4	virus	virus	NN
cord-321607-3r736dnk	486	5	RNA	RNA	NNP
cord-321607-3r736dnk	486	6	:	:	:
cord-321607-3r736dnk	486	7	Dinucleotide	dinucleotide	NN
cord-321607-3r736dnk	486	8	frequencies	frequency	NNS
cord-321607-3r736dnk	486	9	and	and	CC
cord-321607-3r736dnk	486	10	cleavage	cleavage	NN
cord-321607-3r736dnk	486	11	by	by	IN
cord-321607-3r736dnk	486	12	RNase	RNase	NNP
cord-321607-3r736dnk	486	13	L	L	NNP
cord-321607-3r736dnk	486	14	Clinical	clinical	JJ
cord-321607-3r736dnk	486	15	relevance	relevance	NN
cord-321607-3r736dnk	486	16	of	of	IN
cord-321607-3r736dnk	486	17	the	the	DT
cord-321607-3r736dnk	486	18	2	2	CD
cord-321607-3r736dnk	486	19	1	1	CD
cord-321607-3r736dnk	486	20	-5	-5	CD
cord-321607-3r736dnk	486	21	1	1	CD
cord-321607-3r736dnk	486	22	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	486	23	synthetase	synthetase	NN
cord-321607-3r736dnk	486	24	/	/	SYM
cord-321607-3r736dnk	486	25	RNase	rnase	NN
cord-321607-3r736dnk	486	26	L	l	NN
cord-321607-3r736dnk	486	27	system	system	NN
cord-321607-3r736dnk	486	28	for	for	IN
cord-321607-3r736dnk	486	29	treatment	treatment	NN
cord-321607-3r736dnk	486	30	response	response	NN
cord-321607-3r736dnk	486	31	in	in	IN
cord-321607-3r736dnk	486	32	chronic	chronic	JJ
cord-321607-3r736dnk	486	33	hepatitis	hepatitis	NN
cord-321607-3r736dnk	486	34	c	c	NN
cord-321607-3r736dnk	486	35	RNase	RNase	NNP
cord-321607-3r736dnk	486	36	L	L	NNP
cord-321607-3r736dnk	486	37	targets	target	VBZ
cord-321607-3r736dnk	486	38	distinct	distinct	JJ
cord-321607-3r736dnk	486	39	sites	site	NNS
cord-321607-3r736dnk	486	40	in	in	IN
cord-321607-3r736dnk	486	41	influenza	influenza	NN
cord-321607-3r736dnk	487	1	a	a	DT
cord-321607-3r736dnk	487	2	virus	virus	NN
cord-321607-3r736dnk	487	3	RNAs	rna	NNS
cord-321607-3r736dnk	488	1	The	the	DT
cord-321607-3r736dnk	488	2	primary	primary	JJ
cord-321607-3r736dnk	488	3	function	function	NN
cord-321607-3r736dnk	488	4	of	of	IN
cord-321607-3r736dnk	488	5	RNA	RNA	NNP
cord-321607-3r736dnk	488	6	binding	bind	VBG
cord-321607-3r736dnk	488	7	by	by	IN
cord-321607-3r736dnk	488	8	the	the	DT
cord-321607-3r736dnk	488	9	influenza	influenza	NN
cord-321607-3r736dnk	488	10	A	a	DT
cord-321607-3r736dnk	488	11	virus	virus	NN
cord-321607-3r736dnk	488	12	NS1	ns1	CD
cord-321607-3r736dnk	488	13	protein	protein	NN
cord-321607-3r736dnk	488	14	in	in	IN
cord-321607-3r736dnk	488	15	infected	infected	JJ
cord-321607-3r736dnk	488	16	cells	cell	NNS
cord-321607-3r736dnk	488	17	:	:	:
cord-321607-3r736dnk	489	1	Inhibiting	inhibit	VBG
cord-321607-3r736dnk	489	2	the	the	DT
cord-321607-3r736dnk	489	3	2	2	CD
cord-321607-3r736dnk	489	4	1	1	CD
cord-321607-3r736dnk	489	5	-5	-5	CD
cord-321607-3r736dnk	489	6	1	1	CD
cord-321607-3r736dnk	489	7	oligo	oligo	NN
cord-321607-3r736dnk	489	8	(	(	-LRB-
cord-321607-3r736dnk	489	9	A	a	NN
cord-321607-3r736dnk	489	10	)	)	-RRB-
cord-321607-3r736dnk	489	11	synthetase	synthetase	NN
cord-321607-3r736dnk	489	12	/	/	SYM
cord-321607-3r736dnk	489	13	RNase	rnase	NN
cord-321607-3r736dnk	489	14	L	L	NNP
cord-321607-3r736dnk	489	15	pathway	pathway	NN
cord-321607-3r736dnk	489	16	Mechanisms	Mechanisms	NNPS
cord-321607-3r736dnk	489	17	of	of	IN
cord-321607-3r736dnk	489	18	IFN	IFN	NNP
cord-321607-3r736dnk	489	19	resistance	resistance	NN
cord-321607-3r736dnk	489	20	by	by	IN
cord-321607-3r736dnk	489	21	influenza	influenza	NN
cord-321607-3r736dnk	489	22	virus	virus	NN
cord-321607-3r736dnk	489	23	Diagnostic	diagnostic	JJ
cord-321607-3r736dnk	489	24	value	value	NN
cord-321607-3r736dnk	489	25	of	of	IN
cord-321607-3r736dnk	489	26	the	the	DT
cord-321607-3r736dnk	489	27	determination	determination	NN
cord-321607-3r736dnk	489	28	of	of	IN
cord-321607-3r736dnk	489	29	an	an	DT
cord-321607-3r736dnk	489	30	interferon	interferon	NN
cord-321607-3r736dnk	489	31	-	-	HYPH
cord-321607-3r736dnk	489	32	induced	induce	VBN
cord-321607-3r736dnk	489	33	enzyme	enzyme	NN
cord-321607-3r736dnk	489	34	activity	activity	NN
cord-321607-3r736dnk	489	35	:	:	:
cord-321607-3r736dnk	489	36	Decreased	decrease	VBD
cord-321607-3r736dnk	489	37	2	2	CD
cord-321607-3r736dnk	489	38	1	1	CD
cord-321607-3r736dnk	489	39	,	,	,
cord-321607-3r736dnk	489	40	5	5	CD
cord-321607-3r736dnk	489	41	1	1	CD
cord-321607-3r736dnk	489	42	-oligoadenylate	-oligoadenylate	JJ
cord-321607-3r736dnk	489	43	dependent	dependent	JJ
cord-321607-3r736dnk	489	44	binding	bind	VBG
cord-321607-3r736dnk	489	45	protein	protein	NN
cord-321607-3r736dnk	489	46	activity	activity	NN
cord-321607-3r736dnk	489	47	in	in	IN
cord-321607-3r736dnk	489	48	aids	aids	NNP
cord-321607-3r736dnk	489	49	patient	patient	NN
cord-321607-3r736dnk	489	50	lymphocytes	lymphocyte	VBZ
cord-321607-3r736dnk	489	51	Antagonism	antagonism	NN
cord-321607-3r736dnk	489	52	of	of	IN
cord-321607-3r736dnk	489	53	the	the	DT
cord-321607-3r736dnk	489	54	interferon	interferon	NN
cord-321607-3r736dnk	489	55	-	-	HYPH
cord-321607-3r736dnk	489	56	induced	induce	VBN
cord-321607-3r736dnk	489	57	OAS	OAS	NNP
cord-321607-3r736dnk	489	58	-	-	HYPH
cord-321607-3r736dnk	489	59	RNase	RNase	NNP
cord-321607-3r736dnk	489	60	L	l	NN
cord-321607-3r736dnk	489	61	pathway	pathway	NN
cord-321607-3r736dnk	489	62	by	by	IN
cord-321607-3r736dnk	489	63	murine	murine	JJ
cord-321607-3r736dnk	489	64	coronavirus	coronavirus	NN
cord-321607-3r736dnk	490	1	ns2	ns2	NNP
cord-321607-3r736dnk	490	2	protein	protein	NN
cord-321607-3r736dnk	490	3	is	be	VBZ
cord-321607-3r736dnk	490	4	required	require	VBN
cord-321607-3r736dnk	490	5	for	for	IN
cord-321607-3r736dnk	490	6	virus	virus	NN
cord-321607-3r736dnk	490	7	replication	replication	NN
cord-321607-3r736dnk	490	8	and	and	CC
cord-321607-3r736dnk	490	9	liver	liver	NN
cord-321607-3r736dnk	490	10	pathology	pathology	NN
cord-321607-3r736dnk	490	11	Inhibition	inhibition	NN
cord-321607-3r736dnk	490	12	of	of	IN
cord-321607-3r736dnk	490	13	the	the	DT
cord-321607-3r736dnk	490	14	OAS	OAS	NNP
cord-321607-3r736dnk	490	15	/	/	SYM
cord-321607-3r736dnk	490	16	RNase	RNase	NNP
cord-321607-3r736dnk	490	17	L	l	NN
cord-321607-3r736dnk	490	18	pathway	pathway	NN
cord-321607-3r736dnk	490	19	by	by	IN
cord-321607-3r736dnk	490	20	viruses	virus	NNS
cord-321607-3r736dnk	490	21	Caspase	Caspase	NNP
cord-321607-3r736dnk	490	22	-	-	HYPH
cord-321607-3r736dnk	490	23	dependent	dependent	JJ
cord-321607-3r736dnk	490	24	apoptosis	apoptosis	NN
cord-321607-3r736dnk	490	25	by	by	IN
cord-321607-3r736dnk	490	26	2	2	CD
cord-321607-3r736dnk	490	27	1	1	CD
cord-321607-3r736dnk	490	28	,	,	,
cord-321607-3r736dnk	490	29	5	5	CD
cord-321607-3r736dnk	490	30	1	1	CD
cord-321607-3r736dnk	490	31	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	490	32	activation	activation	NN
cord-321607-3r736dnk	490	33	of	of	IN
cord-321607-3r736dnk	490	34	RNase	RNase	NNP
cord-321607-3r736dnk	490	35	L	L	NNP
cord-321607-3r736dnk	490	36	is	be	VBZ
cord-321607-3r736dnk	490	37	enhanced	enhance	VBN
cord-321607-3r736dnk	490	38	by	by	IN
cord-321607-3r736dnk	490	39	IFN	IFN	NNP
cord-321607-3r736dnk	490	40	-	-	HYPH
cord-321607-3r736dnk	490	41	β	β	NNP
cord-321607-3r736dnk	490	42	Viruses	virus	NNS
cord-321607-3r736dnk	490	43	and	and	CC
cord-321607-3r736dnk	490	44	the	the	DT
cord-321607-3r736dnk	490	45	autophagy	autophagy	NN
cord-321607-3r736dnk	490	46	pathway	pathway	NN
cord-321607-3r736dnk	490	47	RNase	RNase	NNP
cord-321607-3r736dnk	490	48	L	L	NNP
cord-321607-3r736dnk	490	49	triggers	trigger	VBZ
cord-321607-3r736dnk	490	50	autophagy	autophagy	NN
cord-321607-3r736dnk	490	51	in	in	IN
cord-321607-3r736dnk	490	52	response	response	NN
cord-321607-3r736dnk	490	53	to	to	IN
cord-321607-3r736dnk	490	54	viral	viral	JJ
cord-321607-3r736dnk	490	55	infections	infection	NNS
cord-321607-3r736dnk	491	1	The	the	DT
cord-321607-3r736dnk	491	2	crosstalk	crosstalk	NN
cord-321607-3r736dnk	491	3	between	between	IN
cord-321607-3r736dnk	491	4	autophagy	autophagy	NN
cord-321607-3r736dnk	491	5	and	and	CC
cord-321607-3r736dnk	491	6	apoptosis	apoptosis	NN
cord-321607-3r736dnk	491	7	:	:	:
cord-321607-3r736dnk	491	8	Where	where	WRB
cord-321607-3r736dnk	491	9	does	do	VBZ
cord-321607-3r736dnk	491	10	this	this	DT
cord-321607-3r736dnk	491	11	lead	lead	VB
cord-321607-3r736dnk	491	12	Regulation	regulation	NN
cord-321607-3r736dnk	491	13	of	of	IN
cord-321607-3r736dnk	491	14	antiviral	antiviral	JJ
cord-321607-3r736dnk	491	15	T	t	NN
cord-321607-3r736dnk	491	16	cell	cell	NN
cord-321607-3r736dnk	491	17	responses	response	NNS
cord-321607-3r736dnk	491	18	by	by	IN
cord-321607-3r736dnk	491	19	type	type	NN
cord-321607-3r736dnk	491	20	I	-PRON-	PRP
cord-321607-3r736dnk	491	21	interferons	interferon	NNS
cord-321607-3r736dnk	491	22	Transcription	Transcription	NNP
cord-321607-3r736dnk	491	23	factor	factor	NN
cord-321607-3r736dnk	491	24	STAT3	stat3	NN
cord-321607-3r736dnk	491	25	and	and	CC
cord-321607-3r736dnk	491	26	type	type	NN
cord-321607-3r736dnk	492	1	I	-PRON-	PRP
cord-321607-3r736dnk	492	2	interferons	interferon	NNS
cord-321607-3r736dnk	492	3	are	be	VBP
cord-321607-3r736dnk	492	4	corepressive	corepressive	JJ
cord-321607-3r736dnk	492	5	insulators	insulator	NNS
cord-321607-3r736dnk	492	6	for	for	IN
cord-321607-3r736dnk	492	7	differentiation	differentiation	NN
cord-321607-3r736dnk	492	8	of	of	IN
cord-321607-3r736dnk	492	9	follicular	follicular	JJ
cord-321607-3r736dnk	492	10	helper	helper	NN
cord-321607-3r736dnk	492	11	and	and	CC
cord-321607-3r736dnk	492	12	T	T	NNP
cord-321607-3r736dnk	492	13	helper	helper	NN
cord-321607-3r736dnk	493	1	1	1	CD
cord-321607-3r736dnk	493	2	cells	cell	NNS
cord-321607-3r736dnk	493	3	Type	type	NN
cord-321607-3r736dnk	493	4	I	-PRON-	PRP
cord-321607-3r736dnk	493	5	IFN	IFN	NNP
cord-321607-3r736dnk	493	6	enhances	enhance	VBZ
cord-321607-3r736dnk	493	7	follicular	follicular	JJ
cord-321607-3r736dnk	493	8	b	b	NNP
cord-321607-3r736dnk	493	9	cell	cell	NN
cord-321607-3r736dnk	493	10	contribution	contribution	NN
cord-321607-3r736dnk	493	11	to	to	IN
cord-321607-3r736dnk	493	12	the	the	DT
cord-321607-3r736dnk	493	13	T	T	NNP
cord-321607-3r736dnk	493	14	cell	cell	NN
cord-321607-3r736dnk	493	15	-	-	HYPH
cord-321607-3r736dnk	493	16	independent	independent	JJ
cord-321607-3r736dnk	493	17	antibody	antibody	NN
cord-321607-3r736dnk	493	18	response	response	NN
cord-321607-3r736dnk	493	19	NOD	NOD	NNP
cord-321607-3r736dnk	493	20	-	-	HYPH
cord-321607-3r736dnk	493	21	like	like	JJ
cord-321607-3r736dnk	493	22	receptors	receptor	NNS
cord-321607-3r736dnk	493	23	:	:	:
cord-321607-3r736dnk	494	1	Guardians	guardian	NNS
cord-321607-3r736dnk	494	2	of	of	IN
cord-321607-3r736dnk	494	3	intestinal	intestinal	JJ
cord-321607-3r736dnk	494	4	mucosal	mucosal	JJ
cord-321607-3r736dnk	494	5	barriers	barrier	NNS
cord-321607-3r736dnk	494	6	Nucleotide	Nucleotide	NNP
cord-321607-3r736dnk	494	7	oligomerization	oligomerization	NN
cord-321607-3r736dnk	494	8	domain-2	domain-2	NNS
cord-321607-3r736dnk	494	9	interacts	interact	VBZ
cord-321607-3r736dnk	494	10	with	with	IN
cord-321607-3r736dnk	494	11	2	2	CD
cord-321607-3r736dnk	494	12	1	1	CD
cord-321607-3r736dnk	494	13	-5	-5	CD
cord-321607-3r736dnk	494	14	1	1	CD
cord-321607-3r736dnk	494	15	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	494	16	synthetase	synthetase	NN
cord-321607-3r736dnk	494	17	type	type	NN
cord-321607-3r736dnk	494	18	2	2	CD
cord-321607-3r736dnk	494	19	and	and	CC
cord-321607-3r736dnk	494	20	enhances	enhance	VBZ
cord-321607-3r736dnk	494	21	RNase	rnase	NN
cord-321607-3r736dnk	494	22	-	-	HYPH
cord-321607-3r736dnk	494	23	L	l	NN
cord-321607-3r736dnk	494	24	function	function	NN
cord-321607-3r736dnk	494	25	in	in	IN
cord-321607-3r736dnk	494	26	thp-1	thp-1	NNP
cord-321607-3r736dnk	494	27	cells	cell	NNS
cord-321607-3r736dnk	494	28	2	2	CD
cord-321607-3r736dnk	494	29	1	1	CD
cord-321607-3r736dnk	494	30	,	,	,
cord-321607-3r736dnk	495	1	5	5	CD
cord-321607-3r736dnk	495	2	1	1	CD
cord-321607-3r736dnk	495	3	-oligoadenylate	-oligoadenylate	HYPH
cord-321607-3r736dnk	495	4	-	-	HYPH
cord-321607-3r736dnk	495	5	dependent	dependent	JJ
cord-321607-3r736dnk	495	6	RNase	rnase	NN
cord-321607-3r736dnk	495	7	located	locate	VBN
cord-321607-3r736dnk	495	8	in	in	IN
cord-321607-3r736dnk	495	9	nuclei	nucleus	NNS
cord-321607-3r736dnk	495	10	:	:	:
cord-321607-3r736dnk	495	11	Biochemical	biochemical	JJ
cord-321607-3r736dnk	495	12	characterization	characterization	NN
cord-321607-3r736dnk	495	13	and	and	CC
cord-321607-3r736dnk	495	14	subcellular	subcellular	JJ
cord-321607-3r736dnk	495	15	distribution	distribution	NN
cord-321607-3r736dnk	495	16	of	of	IN
cord-321607-3r736dnk	495	17	the	the	DT
cord-321607-3r736dnk	495	18	nuclease	nuclease	NN
cord-321607-3r736dnk	495	19	in	in	IN
cord-321607-3r736dnk	495	20	human	human	JJ
cord-321607-3r736dnk	495	21	and	and	CC
cord-321607-3r736dnk	495	22	murine	murine	JJ
cord-321607-3r736dnk	495	23	cells	cell	NNS
cord-321607-3r736dnk	495	24	Expression	expression	NN
cord-321607-3r736dnk	495	25	of	of	IN
cord-321607-3r736dnk	495	26	mRNA	mrna	NN
cord-321607-3r736dnk	495	27	and	and	CC
cord-321607-3r736dnk	495	28	protein	protein	NN
cord-321607-3r736dnk	495	29	-	-	HYPH
cord-321607-3r736dnk	495	30	protein	protein	NN
cord-321607-3r736dnk	495	31	interaction	interaction	NN
cord-321607-3r736dnk	495	32	of	of	IN
cord-321607-3r736dnk	495	33	the	the	DT
cord-321607-3r736dnk	495	34	antiviral	antiviral	JJ
cord-321607-3r736dnk	495	35	endoribonuclease	endoribonuclease	NN
cord-321607-3r736dnk	495	36	RNase	RNase	NNP
cord-321607-3r736dnk	495	37	L	L	NNP
cord-321607-3r736dnk	495	38	in	in	IN
cord-321607-3r736dnk	495	39	mouse	mouse	NN
cord-321607-3r736dnk	495	40	spleen	spleen	NN
cord-321607-3r736dnk	495	41	Localization	localization	NN
cord-321607-3r736dnk	495	42	of	of	IN
cord-321607-3r736dnk	495	43	a	a	DT
cord-321607-3r736dnk	495	44	molecular	molecular	JJ
cord-321607-3r736dnk	495	45	form	form	NN
cord-321607-3r736dnk	495	46	of	of	IN
cord-321607-3r736dnk	495	47	interferon	interferon	NN
cord-321607-3r736dnk	495	48	-	-	HYPH
cord-321607-3r736dnk	495	49	regulated	regulate	VBN
cord-321607-3r736dnk	495	50	RNase	RNase	NNP
cord-321607-3r736dnk	495	51	L	l	NN
cord-321607-3r736dnk	495	52	in	in	IN
cord-321607-3r736dnk	495	53	the	the	DT
cord-321607-3r736dnk	495	54	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	495	55	Arf1	Arf1	NNP
cord-321607-3r736dnk	495	56	and	and	CC
cord-321607-3r736dnk	495	57	arf6	arf6	VB
cord-321607-3r736dnk	495	58	promote	promote	VB
cord-321607-3r736dnk	495	59	ventral	ventral	JJ
cord-321607-3r736dnk	495	60	actin	actin	NN
cord-321607-3r736dnk	495	61	structures	structure	NNS
cord-321607-3r736dnk	495	62	formed	form	VBN
cord-321607-3r736dnk	495	63	by	by	IN
cord-321607-3r736dnk	495	64	acute	acute	JJ
cord-321607-3r736dnk	495	65	activation	activation	NN
cord-321607-3r736dnk	495	66	of	of	IN
cord-321607-3r736dnk	495	67	protein	protein	NN
cord-321607-3r736dnk	495	68	kinase	kinase	NN
cord-321607-3r736dnk	495	69	c	c	NNP
cord-321607-3r736dnk	495	70	and	and	CC
cord-321607-3r736dnk	495	71	src	src	NNP
cord-321607-3r736dnk	495	72	Activation	Activation	NNP
cord-321607-3r736dnk	495	73	of	of	IN
cord-321607-3r736dnk	495	74	PKCβII	pkcβii	NN
cord-321607-3r736dnk	495	75	by	by	IN
cord-321607-3r736dnk	495	76	PMA	PMA	NNP
cord-321607-3r736dnk	495	77	facilitates	facilitate	VBZ
cord-321607-3r736dnk	495	78	enhanced	enhance	VBN
cord-321607-3r736dnk	495	79	epithelial	epithelial	NN
cord-321607-3r736dnk	495	80	wound	wound	NN
cord-321607-3r736dnk	495	81	repair	repair	NN
cord-321607-3r736dnk	495	82	through	through	IN
cord-321607-3r736dnk	495	83	increased	increase	VBN
cord-321607-3r736dnk	495	84	cell	cell	NN
cord-321607-3r736dnk	495	85	spreading	spreading	NN
cord-321607-3r736dnk	495	86	and	and	CC
cord-321607-3r736dnk	495	87	migration	migration	NN
cord-321607-3r736dnk	495	88	Rodriguez	Rodriguez	NNP
cord-321607-3r736dnk	495	89	-	-	HYPH
cord-321607-3r736dnk	495	90	Boulan	Boulan	NNP
cord-321607-3r736dnk	495	91	,	,	,
cord-321607-3r736dnk	495	92	E.	E.	NNP
cord-321607-3r736dnk	495	93	IQGAP1	IQGAP1	NNP
cord-321607-3r736dnk	495	94	controls	control	VBZ
cord-321607-3r736dnk	495	95	tight	tight	JJ
cord-321607-3r736dnk	495	96	junction	junction	NN
cord-321607-3r736dnk	495	97	formation	formation	NN
cord-321607-3r736dnk	495	98	through	through	IN
cord-321607-3r736dnk	495	99	differential	differential	JJ
cord-321607-3r736dnk	495	100	regulation	regulation	NN
cord-321607-3r736dnk	495	101	of	of	IN
cord-321607-3r736dnk	495	102	claudin	claudin	NN
cord-321607-3r736dnk	495	103	recruitment	recruitment	NN
cord-321607-3r736dnk	495	104	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	495	105	:	:	:
cord-321607-3r736dnk	496	1	Insights	insight	NNS
cord-321607-3r736dnk	496	2	into	into	IN
cord-321607-3r736dnk	496	3	the	the	DT
cord-321607-3r736dnk	496	4	function	function	NN
cord-321607-3r736dnk	496	5	of	of	IN
cord-321607-3r736dnk	496	6	a	a	DT
cord-321607-3r736dnk	496	7	molecular	molecular	JJ
cord-321607-3r736dnk	496	8	puppeteer	puppeteer	NN
cord-321607-3r736dnk	496	9	Pathologic	pathologic	JJ
cord-321607-3r736dnk	496	10	effects	effect	NNS
cord-321607-3r736dnk	496	11	of	of	IN
cord-321607-3r736dnk	496	12	RNase	RNase	NNP
cord-321607-3r736dnk	496	13	-	-	HYPH
cord-321607-3r736dnk	496	14	L	l	NN
cord-321607-3r736dnk	496	15	dysregulation	dysregulation	NN
cord-321607-3r736dnk	496	16	in	in	IN
cord-321607-3r736dnk	496	17	immunity	immunity	NN
cord-321607-3r736dnk	496	18	and	and	CC
cord-321607-3r736dnk	496	19	proliferative	proliferative	JJ
cord-321607-3r736dnk	496	20	control	control	NN
cord-321607-3r736dnk	496	21	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	496	22	in	in	IN
cord-321607-3r736dnk	496	23	microbial	microbial	JJ
cord-321607-3r736dnk	496	24	pathogenesis	pathogenesis	NN
cord-321607-3r736dnk	496	25	:	:	:
cord-321607-3r736dnk	496	26	Targeting	target	VBG
cord-321607-3r736dnk	496	27	the	the	DT
cord-321607-3r736dnk	496	28	actin	actin	NN
cord-321607-3r736dnk	496	29	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	496	30	Role	role	NN
cord-321607-3r736dnk	496	31	of	of	IN
cord-321607-3r736dnk	496	32	RNase	RNase	NNP
cord-321607-3r736dnk	496	33	L	l	NN
cord-321607-3r736dnk	496	34	in	in	IN
cord-321607-3r736dnk	496	35	apoptosis	apoptosis	NN
cord-321607-3r736dnk	496	36	induced	induce	VBN
cord-321607-3r736dnk	496	37	by	by	IN
cord-321607-3r736dnk	496	38	1-(3-C	1-(3-c	CD
cord-321607-3r736dnk	496	39	-	-	HYPH
cord-321607-3r736dnk	496	40	ethynyl	ethynyl	NNP
cord-321607-3r736dnk	496	41	-	-	HYPH
cord-321607-3r736dnk	496	42	β	β	NN
cord-321607-3r736dnk	496	43	-	-	HYPH
cord-321607-3r736dnk	496	44	D	D	NNP
cord-321607-3r736dnk	496	45	-	-	HYPH
cord-321607-3r736dnk	496	46	ribopentofuranosyl)cytosine	ribopentofuranosyl)cytosine	NNP
cord-321607-3r736dnk	496	47	Association	Association	NNP
cord-321607-3r736dnk	496	48	of	of	IN
cord-321607-3r736dnk	496	49	RNase	RNase	NNP
cord-321607-3r736dnk	496	50	L	L	NNP
cord-321607-3r736dnk	496	51	with	with	IN
cord-321607-3r736dnk	496	52	a	a	DT
cord-321607-3r736dnk	496	53	ras	ras	NNP
cord-321607-3r736dnk	496	54	GTPase	GTPase	NNP
cord-321607-3r736dnk	496	55	-	-	HYPH
cord-321607-3r736dnk	496	56	activating	activate	VBG
cord-321607-3r736dnk	496	57	-	-	HYPH
cord-321607-3r736dnk	496	58	like	like	JJ
cord-321607-3r736dnk	496	59	protein	protein	NN
cord-321607-3r736dnk	496	60	IQGAP1	iqgap1	NN
cord-321607-3r736dnk	496	61	in	in	IN
cord-321607-3r736dnk	496	62	mediating	mediate	VBG
cord-321607-3r736dnk	496	63	the	the	DT
cord-321607-3r736dnk	496	64	apoptosis	apoptosis	NN
cord-321607-3r736dnk	496	65	of	of	IN
cord-321607-3r736dnk	496	66	a	a	DT
cord-321607-3r736dnk	496	67	human	human	JJ
cord-321607-3r736dnk	496	68	cancer	cancer	NN
cord-321607-3r736dnk	496	69	cell	cell	NN
cord-321607-3r736dnk	496	70	-	-	HYPH
cord-321607-3r736dnk	496	71	line	line	NN
cord-321607-3r736dnk	497	1	The	the	DT
cord-321607-3r736dnk	497	2	mammalian	mammalian	JJ
cord-321607-3r736dnk	497	3	numb	numb	JJ
cord-321607-3r736dnk	497	4	phosphotyrosine	phosphotyrosine	NN
cord-321607-3r736dnk	497	5	-	-	HYPH
cord-321607-3r736dnk	497	6	binding	bind	VBG
cord-321607-3r736dnk	497	7	domain	domain	NN
cord-321607-3r736dnk	497	8	.	.	.
cord-321607-3r736dnk	498	1	Characterization	characterization	NN
cord-321607-3r736dnk	498	2	of	of	IN
cord-321607-3r736dnk	498	3	binding	bind	VBG
cord-321607-3r736dnk	498	4	specificity	specificity	NN
cord-321607-3r736dnk	498	5	and	and	CC
cord-321607-3r736dnk	498	6	identification	identification	NN
cord-321607-3r736dnk	498	7	of	of	IN
cord-321607-3r736dnk	498	8	a	a	DT
cord-321607-3r736dnk	498	9	novel	novel	JJ
cord-321607-3r736dnk	498	10	pdz	pdz	NN
cord-321607-3r736dnk	498	11	domain	domain	NN
cord-321607-3r736dnk	498	12	-	-	HYPH
cord-321607-3r736dnk	498	13	containing	contain	VBG
cord-321607-3r736dnk	498	14	numb	numb	JJ
cord-321607-3r736dnk	498	15	binding	bind	VBG
cord-321607-3r736dnk	498	16	protein	protein	NN
cord-321607-3r736dnk	498	17	,	,	,
cord-321607-3r736dnk	498	18	lnx	lnx	NNP
cord-321607-3r736dnk	498	19	Lnx	Lnx	NNP
cord-321607-3r736dnk	498	20	functions	function	NNS
cord-321607-3r736dnk	498	21	as	as	IN
cord-321607-3r736dnk	498	22	a	a	DT
cord-321607-3r736dnk	498	23	ring	ring	NN
cord-321607-3r736dnk	498	24	type	type	NN
cord-321607-3r736dnk	498	25	e3	e3	NN
cord-321607-3r736dnk	498	26	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	498	27	ligase	ligase	NN
cord-321607-3r736dnk	498	28	that	that	WDT
cord-321607-3r736dnk	498	29	targets	target	VBZ
cord-321607-3r736dnk	498	30	the	the	DT
cord-321607-3r736dnk	498	31	cell	cell	NN
cord-321607-3r736dnk	498	32	fate	fate	NN
cord-321607-3r736dnk	498	33	determinant	determinant	NN
cord-321607-3r736dnk	498	34	numb	numb	JJ
cord-321607-3r736dnk	498	35	for	for	IN
cord-321607-3r736dnk	498	36	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	498	37	-	-	HYPH
cord-321607-3r736dnk	498	38	dependent	dependent	JJ
cord-321607-3r736dnk	498	39	degradation	degradation	NN
cord-321607-3r736dnk	498	40	Proteomics	Proteomics	NNP
cord-321607-3r736dnk	498	41	strategy	strategy	NN
cord-321607-3r736dnk	498	42	to	to	TO
cord-321607-3r736dnk	498	43	identify	identify	VB
cord-321607-3r736dnk	498	44	substrates	substrate	NNS
cord-321607-3r736dnk	498	45	of	of	IN
cord-321607-3r736dnk	498	46	lnx	lnx	NNP
cord-321607-3r736dnk	498	47	,	,	,
cord-321607-3r736dnk	498	48	a	a	DT
cord-321607-3r736dnk	498	49	pdz	pdz	NN
cord-321607-3r736dnk	498	50	domain	domain	NN
cord-321607-3r736dnk	498	51	-	-	HYPH
cord-321607-3r736dnk	498	52	containing	contain	VBG
cord-321607-3r736dnk	498	53	e3	e3	NNP
cord-321607-3r736dnk	498	54	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	498	55	ligase	ligase	NN
cord-321607-3r736dnk	498	56	Characterization	characterization	NN
cord-321607-3r736dnk	498	57	of	of	IN
cord-321607-3r736dnk	498	58	human	human	JJ
cord-321607-3r736dnk	498	59	lnx	lnx	NN
cord-321607-3r736dnk	498	60	,	,	,
cord-321607-3r736dnk	498	61	a	a	DT
cord-321607-3r736dnk	498	62	novel	novel	JJ
cord-321607-3r736dnk	498	63	Ligand	Ligand	NNP
cord-321607-3r736dnk	498	64	of	of	IN
cord-321607-3r736dnk	498	65	Numb	Numb	NNP
cord-321607-3r736dnk	498	66	protein	protein	NN
cord-321607-3r736dnk	498	67	X	X	NNP
cord-321607-3r736dnk	498	68	that	that	WDT
cord-321607-3r736dnk	498	69	is	be	VBZ
cord-321607-3r736dnk	498	70	downregulated	downregulate	VBN
cord-321607-3r736dnk	498	71	in	in	IN
cord-321607-3r736dnk	498	72	human	human	JJ
cord-321607-3r736dnk	498	73	gliomas	glioma	NNS
cord-321607-3r736dnk	498	74	Ectopic	ectopic	JJ
cord-321607-3r736dnk	498	75	expression	expression	NN
cord-321607-3r736dnk	498	76	of	of	IN
cord-321607-3r736dnk	498	77	Ligand	ligand	NN
cord-321607-3r736dnk	498	78	-	-	HYPH
cord-321607-3r736dnk	498	79	of	of	IN
cord-321607-3r736dnk	498	80	-	-	HYPH
cord-321607-3r736dnk	498	81	Numb	Numb	NNP
cord-321607-3r736dnk	498	82	protein	protein	NN
cord-321607-3r736dnk	498	83	X	x	NN
cord-321607-3r736dnk	499	1	promoted	promote	VBN
cord-321607-3r736dnk	499	2	TGF	TGF	NNP
cord-321607-3r736dnk	499	3	-	-	HYPH
cord-321607-3r736dnk	499	4	β	β	NN
cord-321607-3r736dnk	499	5	induced	induce	VBN
cord-321607-3r736dnk	499	6	epithelial	epithelial	JJ
cord-321607-3r736dnk	499	7	to	to	IN
cord-321607-3r736dnk	499	8	mesenchymal	mesenchymal	JJ
cord-321607-3r736dnk	499	9	transition	transition	NN
cord-321607-3r736dnk	499	10	of	of	IN
cord-321607-3r736dnk	499	11	proximal	proximal	JJ
cord-321607-3r736dnk	499	12	tubular	tubular	JJ
cord-321607-3r736dnk	499	13	epithelial	epithelial	JJ
cord-321607-3r736dnk	499	14	cells	cell	NNS
cord-321607-3r736dnk	500	1	The	the	DT
cord-321607-3r736dnk	500	2	e3	e3	NNP
cord-321607-3r736dnk	500	3	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	500	4	ligase	ligase	NN
cord-321607-3r736dnk	500	5	lnx1p80	lnx1p80	NNP
cord-321607-3r736dnk	500	6	promotes	promote	VBZ
cord-321607-3r736dnk	500	7	the	the	DT
cord-321607-3r736dnk	500	8	removal	removal	NN
cord-321607-3r736dnk	500	9	of	of	IN
cord-321607-3r736dnk	500	10	claudins	claudin	NNS
cord-321607-3r736dnk	500	11	from	from	IN
cord-321607-3r736dnk	500	12	tight	tight	JJ
cord-321607-3r736dnk	500	13	junctions	junction	NNS
cord-321607-3r736dnk	500	14	in	in	IN
cord-321607-3r736dnk	500	15	mdck	mdck	NNP
cord-321607-3r736dnk	500	16	cells	cell	NNS
cord-321607-3r736dnk	500	17	Moelling	Moelling	NNP
cord-321607-3r736dnk	500	18	,	,	,
cord-321607-3r736dnk	500	19	K.	K.	NNP
cord-321607-3r736dnk	500	20	C	C	NNP
cord-321607-3r736dnk	500	21	-	-	HYPH
cord-321607-3r736dnk	500	22	src	src	NNP
cord-321607-3r736dnk	500	23	is	be	VBZ
cord-321607-3r736dnk	500	24	a	a	DT
cord-321607-3r736dnk	500	25	pdz	pdz	NNP
cord-321607-3r736dnk	500	26	interaction	interaction	NN
cord-321607-3r736dnk	500	27	partner	partner	NN
cord-321607-3r736dnk	500	28	and	and	CC
cord-321607-3r736dnk	500	29	substrate	substrate	NN
cord-321607-3r736dnk	500	30	of	of	IN
cord-321607-3r736dnk	500	31	the	the	DT
cord-321607-3r736dnk	500	32	e3	e3	NNP
cord-321607-3r736dnk	500	33	ubiquitin	ubiquitin	NN
cord-321607-3r736dnk	500	34	ligase	ligase	NN
cord-321607-3r736dnk	501	1	Ligand	ligand	NN
cord-321607-3r736dnk	501	2	-	-	HYPH
cord-321607-3r736dnk	501	3	of	of	IN
cord-321607-3r736dnk	501	4	-	-	HYPH
cord-321607-3r736dnk	501	5	Numb	Numb	NNP
cord-321607-3r736dnk	501	6	protein	protein	NN
cord-321607-3r736dnk	501	7	X1	X1	NNP
cord-321607-3r736dnk	501	8	A	A	NNP
cord-321607-3r736dnk	501	9	global	global	JJ
cord-321607-3r736dnk	501	10	genomic	genomic	JJ
cord-321607-3r736dnk	501	11	view	view	NN
cord-321607-3r736dnk	501	12	on	on	IN
cord-321607-3r736dnk	501	13	lnx	lnx	NNP
cord-321607-3r736dnk	501	14	siRNA	siRNA	NNP
cord-321607-3r736dnk	501	15	-	-	HYPH
cord-321607-3r736dnk	501	16	mediated	mediate	VBN
cord-321607-3r736dnk	501	17	cell	cell	NN
cord-321607-3r736dnk	501	18	cycle	cycle	NN
cord-321607-3r736dnk	501	19	arrest	arrest	NN
cord-321607-3r736dnk	501	20	LNX	LNX	NNP
cord-321607-3r736dnk	502	1	(	(	-LRB-
cord-321607-3r736dnk	502	2	Ligand	Ligand	NNP
cord-321607-3r736dnk	502	3	of	of	IN
cord-321607-3r736dnk	502	4	Numb	Numb	NNP
cord-321607-3r736dnk	502	5	-	-	HYPH
cord-321607-3r736dnk	502	6	Protein	Protein	NNP
cord-321607-3r736dnk	502	7	X	X	NNP
cord-321607-3r736dnk	502	8	)	)	-RRB-
cord-321607-3r736dnk	502	9	interacts	interact	VBZ
cord-321607-3r736dnk	502	10	with	with	IN
cord-321607-3r736dnk	502	11	RhoC	RhoC	NNP
cord-321607-3r736dnk	502	12	,	,	,
cord-321607-3r736dnk	502	13	both	both	DT
cord-321607-3r736dnk	502	14	of	of	IN
cord-321607-3r736dnk	502	15	which	which	WDT
cord-321607-3r736dnk	502	16	regulate	regulate	VBP
cord-321607-3r736dnk	502	17	AP-1-mediated	ap-1-mediated	CD
cord-321607-3r736dnk	502	18	transcriptional	transcriptional	JJ
cord-321607-3r736dnk	502	19	activation	activation	NN
cord-321607-3r736dnk	503	1	Ligand	ligand	NN
cord-321607-3r736dnk	503	2	-	-	HYPH
cord-321607-3r736dnk	503	3	of	of	IN
cord-321607-3r736dnk	503	4	-	-	HYPH
cord-321607-3r736dnk	503	5	Numb	Numb	NNP
cord-321607-3r736dnk	503	6	protein	protein	NN
cord-321607-3r736dnk	503	7	X	x	NN
cord-321607-3r736dnk	503	8	is	be	VBZ
cord-321607-3r736dnk	503	9	an	an	DT
cord-321607-3r736dnk	503	10	endocytic	endocytic	JJ
cord-321607-3r736dnk	503	11	scaffold	scaffold	NN
cord-321607-3r736dnk	503	12	for	for	IN
cord-321607-3r736dnk	503	13	junctional	junctional	JJ
cord-321607-3r736dnk	503	14	adhesion	adhesion	NN
cord-321607-3r736dnk	503	15	molecule	molecule	NN
cord-321607-3r736dnk	503	16	4	4	CD
cord-321607-3r736dnk	504	1	The	the	DT
cord-321607-3r736dnk	504	2	cell	cell	NN
cord-321607-3r736dnk	504	3	surface	surface	NN
cord-321607-3r736dnk	504	4	protein	protein	NN
cord-321607-3r736dnk	504	5	coxsackie	coxsackie	NN
cord-321607-3r736dnk	504	6	-	-	:
cord-321607-3r736dnk	504	7	and	and	CC
cord-321607-3r736dnk	504	8	adenovirus	adenovirus	NN
cord-321607-3r736dnk	504	9	receptor	receptor	NN
cord-321607-3r736dnk	504	10	(	(	-LRB-
cord-321607-3r736dnk	504	11	CAR	car	NN
cord-321607-3r736dnk	504	12	)	)	-RRB-
cord-321607-3r736dnk	505	1	directly	directly	RB
cord-321607-3r736dnk	505	2	associates	associate	NNS
cord-321607-3r736dnk	505	3	with	with	IN
cord-321607-3r736dnk	505	4	the	the	DT
cord-321607-3r736dnk	505	5	Ligand	Ligand	NNP
cord-321607-3r736dnk	505	6	-	-	HYPH
cord-321607-3r736dnk	505	7	of	of	IN
cord-321607-3r736dnk	505	8	The	the	DT
cord-321607-3r736dnk	505	9	coxsackievirus	coxsackievirus	NN
cord-321607-3r736dnk	505	10	and	and	CC
cord-321607-3r736dnk	505	11	adenovirus	adenovirus	NN
cord-321607-3r736dnk	505	12	receptor	receptor	NN
cord-321607-3r736dnk	505	13	(	(	-LRB-
cord-321607-3r736dnk	505	14	CAR	car	NN
cord-321607-3r736dnk	505	15	)	)	-RRB-
cord-321607-3r736dnk	505	16	forms	form	VBZ
cord-321607-3r736dnk	505	17	a	a	DT
cord-321607-3r736dnk	505	18	complex	complex	NN
cord-321607-3r736dnk	505	19	with	with	IN
cord-321607-3r736dnk	505	20	the	the	DT
cord-321607-3r736dnk	505	21	pdz	pdz	NNP
cord-321607-3r736dnk	505	22	domain	domain	NN
cord-321607-3r736dnk	505	23	-	-	HYPH
cord-321607-3r736dnk	505	24	containing	contain	VBG
cord-321607-3r736dnk	505	25	protein	protein	NN
cord-321607-3r736dnk	505	26	Ligand	Ligand	NNP
cord-321607-3r736dnk	505	27	-	-	HYPH
cord-321607-3r736dnk	505	28	of	of	IN
cord-321607-3r736dnk	505	29	-	-	HYPH
cord-321607-3r736dnk	505	30	Numb	Numb	NNP
cord-321607-3r736dnk	505	31	protein	protein	NN
cord-321607-3r736dnk	505	32	-	-	HYPH
cord-321607-3r736dnk	505	33	X	x	NN
cord-321607-3r736dnk	505	34	(	(	-LRB-
cord-321607-3r736dnk	505	35	LNX	LNX	NNP
cord-321607-3r736dnk	505	36	)	)	-RRB-
cord-321607-3r736dnk	505	37	Pathogens	pathogen	NNS
cord-321607-3r736dnk	505	38	and	and	CC
cord-321607-3r736dnk	505	39	polymers	polymer	NNS
cord-321607-3r736dnk	505	40	:	:	:
cord-321607-3r736dnk	506	1	Microbe	microbe	NN
cord-321607-3r736dnk	506	2	-	-	HYPH
cord-321607-3r736dnk	506	3	host	host	NN
cord-321607-3r736dnk	506	4	interactions	interaction	NNS
cord-321607-3r736dnk	506	5	illuminate	illuminate	VBP
cord-321607-3r736dnk	506	6	the	the	DT
cord-321607-3r736dnk	506	7	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	506	8	Viral	viral	JJ
cord-321607-3r736dnk	506	9	exploitation	exploitation	NN
cord-321607-3r736dnk	506	10	of	of	IN
cord-321607-3r736dnk	506	11	actin	actin	NN
cord-321607-3r736dnk	506	12	:	:	:
cord-321607-3r736dnk	506	13	Force	force	NN
cord-321607-3r736dnk	506	14	-	-	HYPH
cord-321607-3r736dnk	506	15	generation	generation	NN
cord-321607-3r736dnk	506	16	and	and	CC
cord-321607-3r736dnk	506	17	scaffolding	scaffolding	NN
cord-321607-3r736dnk	506	18	functions	function	NNS
cord-321607-3r736dnk	506	19	in	in	IN
cord-321607-3r736dnk	506	20	viral	viral	JJ
cord-321607-3r736dnk	506	21	infection	infection	NN
cord-321607-3r736dnk	507	1	Aberrant	aberrant	JJ
cord-321607-3r736dnk	507	2	actin	actin	NN
cord-321607-3r736dnk	507	3	depolymerization	depolymerization	NN
cord-321607-3r736dnk	507	4	triggers	trigger	VBZ
cord-321607-3r736dnk	507	5	the	the	DT
cord-321607-3r736dnk	507	6	pyrin	pyrin	NNP
cord-321607-3r736dnk	507	7	inflammasome	inflammasome	NNP
cord-321607-3r736dnk	507	8	and	and	CC
cord-321607-3r736dnk	507	9	autoinflammatory	autoinflammatory	NNP
cord-321607-3r736dnk	507	10	disease	disease	NN
cord-321607-3r736dnk	507	11	that	that	WDT
cord-321607-3r736dnk	507	12	is	be	VBZ
cord-321607-3r736dnk	507	13	dependent	dependent	JJ
cord-321607-3r736dnk	507	14	on	on	IN
cord-321607-3r736dnk	507	15	IL-18	IL-18	NNP
cord-321607-3r736dnk	507	16	,	,	,
cord-321607-3r736dnk	507	17	not	not	RB
cord-321607-3r736dnk	507	18	IL-1β	IL-1β	NNP
cord-321607-3r736dnk	507	19	Modulation	Modulation	NNP
cord-321607-3r736dnk	507	20	of	of	IN
cord-321607-3r736dnk	507	21	NOD2-dependent	NOD2-dependent	NNP
cord-321607-3r736dnk	507	22	NF	NF	NNP
cord-321607-3r736dnk	507	23	-	-	HYPH
cord-321607-3r736dnk	507	24	κB	κB	NNP
cord-321607-3r736dnk	508	1	signaling	signal	VBG
cord-321607-3r736dnk	508	2	by	by	IN
cord-321607-3r736dnk	508	3	the	the	DT
cord-321607-3r736dnk	508	4	actin	actin	NN
cord-321607-3r736dnk	508	5	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	509	1	Retinoic	retinoic	JJ
cord-321607-3r736dnk	509	2	acid	acid	NN
cord-321607-3r736dnk	509	3	-	-	HYPH
cord-321607-3r736dnk	509	4	induced	induce	VBN
cord-321607-3r736dnk	509	5	gene-1	gene-1	NNP
cord-321607-3r736dnk	510	1	(	(	-LRB-
cord-321607-3r736dnk	510	2	RIG	rig	NN
cord-321607-3r736dnk	510	3	-	-	HYPH
cord-321607-3r736dnk	510	4	I	I	NNP
cord-321607-3r736dnk	510	5	)	)	-RRB-
cord-321607-3r736dnk	510	6	associates	associate	NNS
cord-321607-3r736dnk	510	7	with	with	IN
cord-321607-3r736dnk	510	8	the	the	DT
cord-321607-3r736dnk	510	9	actin	actin	NN
cord-321607-3r736dnk	510	10	cytoskeleton	cytoskeleton	NN
cord-321607-3r736dnk	510	11	via	via	IN
cord-321607-3r736dnk	510	12	caspase	caspase	NN
cord-321607-3r736dnk	510	13	activation	activation	NN
cord-321607-3r736dnk	510	14	and	and	CC
cord-321607-3r736dnk	510	15	recruitment	recruitment	NN
cord-321607-3r736dnk	510	16	domain	domain	NN
cord-321607-3r736dnk	510	17	-	-	HYPH
cord-321607-3r736dnk	510	18	dependent	dependent	JJ
cord-321607-3r736dnk	510	19	interactions	interaction	NNS
cord-321607-3r736dnk	511	1	An	an	DT
cord-321607-3r736dnk	511	2	essential	essential	JJ
cord-321607-3r736dnk	511	3	role	role	NN
cord-321607-3r736dnk	511	4	for	for	IN
cord-321607-3r736dnk	511	5	RIG	rig	NN
cord-321607-3r736dnk	511	6	-	-	:
cord-321607-3r736dnk	511	7	I	i	NN
cord-321607-3r736dnk	511	8	in	in	IN
cord-321607-3r736dnk	511	9	Toll	Toll	NNP
cord-321607-3r736dnk	511	10	-	-	HYPH
cord-321607-3r736dnk	511	11	like	like	JJ
cord-321607-3r736dnk	511	12	receptor	receptor	NN
cord-321607-3r736dnk	511	13	-	-	HYPH
cord-321607-3r736dnk	511	14	stimulated	stimulate	VBN
cord-321607-3r736dnk	511	15	phagocytosis	phagocytosis	NN
cord-321607-3r736dnk	511	16	Focal	focal	JJ
cord-321607-3r736dnk	511	17	adhesion	adhesion	NN
cord-321607-3r736dnk	511	18	kinase	kinase	NN
cord-321607-3r736dnk	511	19	is	be	VBZ
cord-321607-3r736dnk	511	20	a	a	DT
cord-321607-3r736dnk	511	21	component	component	NN
cord-321607-3r736dnk	511	22	of	of	IN
cord-321607-3r736dnk	511	23	antiviral	antiviral	JJ
cord-321607-3r736dnk	511	24	RIG	rig	NN
cord-321607-3r736dnk	511	25	-	-	HYPH
cord-321607-3r736dnk	511	26	I	i	NN
cord-321607-3r736dnk	511	27	-	-	HYPH
cord-321607-3r736dnk	511	28	like	like	JJ
cord-321607-3r736dnk	511	29	receptor	receptor	NN
cord-321607-3r736dnk	511	30	signaling	signal	VBG
cord-321607-3r736dnk	511	31	GEF	GEF	NNP
cord-321607-3r736dnk	511	32	-	-	HYPH
cord-321607-3r736dnk	511	33	H1	H1	NNP
cord-321607-3r736dnk	511	34	controls	control	VBZ
cord-321607-3r736dnk	511	35	microtubule	microtubule	NN
cord-321607-3r736dnk	511	36	-	-	HYPH
cord-321607-3r736dnk	511	37	dependent	dependent	JJ
cord-321607-3r736dnk	511	38	sensing	sensing	NN
cord-321607-3r736dnk	511	39	of	of	IN
cord-321607-3r736dnk	511	40	nucleic	nucleic	JJ
cord-321607-3r736dnk	511	41	acids	acid	NNS
cord-321607-3r736dnk	511	42	for	for	IN
cord-321607-3r736dnk	511	43	antiviral	antiviral	JJ
cord-321607-3r736dnk	511	44	host	host	NN
cord-321607-3r736dnk	511	45	defenses	defense	NNS
cord-321607-3r736dnk	512	1	Flightless	Flightless	NNP
cord-321607-3r736dnk	512	2	-	-	:
cord-321607-3r736dnk	512	3	i	i	PRP
cord-321607-3r736dnk	512	4	regulates	regulate	VBZ
cord-321607-3r736dnk	512	5	proinflammatory	proinflammatory	JJ
cord-321607-3r736dnk	512	6	caspases	caspase	NNS
cord-321607-3r736dnk	512	7	by	by	IN
cord-321607-3r736dnk	512	8	selectively	selectively	RB
cord-321607-3r736dnk	512	9	modulating	modulate	VBG
cord-321607-3r736dnk	512	10	intracellular	intracellular	JJ
cord-321607-3r736dnk	512	11	localization	localization	NN
cord-321607-3r736dnk	512	12	and	and	CC
cord-321607-3r736dnk	512	13	caspase	caspase	NN
cord-321607-3r736dnk	512	14	activity	activity	NN
cord-321607-3r736dnk	513	1	The	the	DT
cord-321607-3r736dnk	513	2	inflammasome	inflammasome	NN
cord-321607-3r736dnk	513	3	adaptor	adaptor	NN
cord-321607-3r736dnk	513	4	ASC	ASC	NNP
cord-321607-3r736dnk	513	5	regulates	regulate	VBZ
cord-321607-3r736dnk	513	6	the	the	DT
cord-321607-3r736dnk	513	7	function	function	NN
cord-321607-3r736dnk	513	8	of	of	IN
cord-321607-3r736dnk	513	9	adaptive	adaptive	JJ
cord-321607-3r736dnk	513	10	immune	immune	JJ
cord-321607-3r736dnk	513	11	cells	cell	NNS
cord-321607-3r736dnk	513	12	by	by	IN
cord-321607-3r736dnk	513	13	controlling	control	VBG
cord-321607-3r736dnk	513	14	Dock2-mediated	Dock2-mediated	NNP
cord-321607-3r736dnk	513	15	rac	rac	NNP
cord-321607-3r736dnk	513	16	activation	activation	NN
cord-321607-3r736dnk	513	17	and	and	CC
cord-321607-3r736dnk	513	18	actin	actin	NN
cord-321607-3r736dnk	513	19	polymerization	polymerization	NN
cord-321607-3r736dnk	513	20	Regulation	regulation	NN
cord-321607-3r736dnk	513	21	of	of	IN
cord-321607-3r736dnk	513	22	actin	actin	NN
cord-321607-3r736dnk	513	23	dynamics	dynamic	NNS
cord-321607-3r736dnk	513	24	by	by	IN
cord-321607-3r736dnk	513	25	protein	protein	NN
cord-321607-3r736dnk	513	26	kinase	kinase	NN
cord-321607-3r736dnk	513	27	R	r	NN
cord-321607-3r736dnk	513	28	control	control	NN
cord-321607-3r736dnk	513	29	of	of	IN
cord-321607-3r736dnk	513	30	gelsolin	gelsolin	NNP
cord-321607-3r736dnk	513	31	enforces	enforce	VBZ
cord-321607-3r736dnk	513	32	basal	basal	NN
cord-321607-3r736dnk	513	33	innate	innate	JJ
cord-321607-3r736dnk	513	34	immune	immune	JJ
cord-321607-3r736dnk	513	35	defense	defense	NN
cord-321607-3r736dnk	513	36	Caspase-11	Caspase-11	NNP
cord-321607-3r736dnk	513	37	regulates	regulate	VBZ
cord-321607-3r736dnk	513	38	cell	cell	NN
cord-321607-3r736dnk	513	39	migration	migration	NN
cord-321607-3r736dnk	513	40	by	by	IN
cord-321607-3r736dnk	513	41	promoting	promote	VBG
cord-321607-3r736dnk	513	42	Aip1-cofilin	Aip1-cofilin	NNP
cord-321607-3r736dnk	513	43	-	-	HYPH
cord-321607-3r736dnk	513	44	mediated	mediate	VBN
cord-321607-3r736dnk	513	45	actin	actin	NN
cord-321607-3r736dnk	513	46	depolymerization	depolymerization	NN
cord-321607-3r736dnk	513	47	ADAP2	adap2	NN
cord-321607-3r736dnk	514	1	is	be	VBZ
cord-321607-3r736dnk	514	2	an	an	DT
cord-321607-3r736dnk	514	3	interferon	interferon	NN
cord-321607-3r736dnk	514	4	stimulated	stimulate	VBN
cord-321607-3r736dnk	514	5	gene	gene	NN
cord-321607-3r736dnk	514	6	that	that	WDT
cord-321607-3r736dnk	514	7	restricts	restrict	VBZ
cord-321607-3r736dnk	514	8	RNA	RNA	NNP
cord-321607-3r736dnk	514	9	virus	virus	NN
cord-321607-3r736dnk	514	10	entry	entry	NN
cord-321607-3r736dnk	515	1	IFITM1	IFITM1	NNP
cord-321607-3r736dnk	515	2	is	be	VBZ
cord-321607-3r736dnk	515	3	a	a	DT
cord-321607-3r736dnk	515	4	tight	tight	JJ
cord-321607-3r736dnk	515	5	junction	junction	NN
cord-321607-3r736dnk	515	6	protein	protein	NN
cord-321607-3r736dnk	515	7	that	that	WDT
cord-321607-3r736dnk	515	8	inhibits	inhibit	VBZ
cord-321607-3r736dnk	515	9	hepatitis	hepatitis	NN
cord-321607-3r736dnk	515	10	C	C	NNP
cord-321607-3r736dnk	515	11	virus	virus	NN
cord-321607-3r736dnk	515	12	entry	entry	NN
cord-321607-3r736dnk	515	13	GEF	GEF	NNP
cord-321607-3r736dnk	515	14	-	-	HYPH
cord-321607-3r736dnk	515	15	H1	h1	NN
cord-321607-3r736dnk	515	16	mediated	mediate	VBN
cord-321607-3r736dnk	515	17	control	control	NN
cord-321607-3r736dnk	515	18	of	of	IN
cord-321607-3r736dnk	515	19	NOD1	NOD1	NNP
cord-321607-3r736dnk	515	20	dependent	dependent	JJ
cord-321607-3r736dnk	515	21	NF	nf	NN
cord-321607-3r736dnk	515	22	-	-	HYPH
cord-321607-3r736dnk	515	23	κB	κb	CD
cord-321607-3r736dnk	515	24	activation	activation	NN
cord-321607-3r736dnk	515	25	by	by	IN
cord-321607-3r736dnk	515	26	shigella	shigella	NNP
cord-321607-3r736dnk	515	27	effectors	effector	NNS
cord-321607-3r736dnk	515	28	Control	Control	NNP
cord-321607-3r736dnk	515	29	of	of	IN
cord-321607-3r736dnk	515	30	NOD2	NOD2	NNPS
cord-321607-3r736dnk	515	31	and	and	CC
cord-321607-3r736dnk	515	32	Rip2-dependent	Rip2-dependent	NNP
cord-321607-3r736dnk	515	33	innate	innate	JJ
cord-321607-3r736dnk	515	34	immune	immune	JJ
cord-321607-3r736dnk	515	35	activation	activation	NN
cord-321607-3r736dnk	515	36	by	by	IN
cord-321607-3r736dnk	515	37	GEF	GEF	NNP
cord-321607-3r736dnk	515	38	-	-	HYPH
cord-321607-3r736dnk	515	39	H1	H1	NNP
cord-321607-3r736dnk	515	40	Innate	innate	JJ
cord-321607-3r736dnk	515	41	immune	immune	JJ
cord-321607-3r736dnk	515	42	sensing	sensing	NN
cord-321607-3r736dnk	515	43	of	of	IN
cord-321607-3r736dnk	515	44	bacterial	bacterial	JJ
cord-321607-3r736dnk	515	45	modifications	modification	NNS
cord-321607-3r736dnk	515	46	of	of	IN
cord-321607-3r736dnk	515	47	Rho	rho	NN
cord-321607-3r736dnk	515	48	GTPases	gtpase	NNS
cord-321607-3r736dnk	515	49	by	by	IN
cord-321607-3r736dnk	516	1	the	the	DT
cord-321607-3r736dnk	516	2	pyrin	pyrin	NNP
cord-321607-3r736dnk	516	3	inflammasome	inflammasome	NNP
cord-321607-3r736dnk	517	1	Caspase-11	Caspase-11	NNP
cord-321607-3r736dnk	517	2	cleaves	cleave	VBZ
cord-321607-3r736dnk	517	3	gasdermin	gasdermin	NNP
cord-321607-3r736dnk	517	4	d	d	NNP
cord-321607-3r736dnk	517	5	for	for	IN
cord-321607-3r736dnk	517	6	non	non	JJ
cord-321607-3r736dnk	517	7	-	-	JJ
cord-321607-3r736dnk	517	8	canonical	canonical	JJ
cord-321607-3r736dnk	517	9	inflammasome	inflammasome	NN
cord-321607-3r736dnk	517	10	signalling	signal	VBG
cord-321607-3r736dnk	517	11	Non	non	JJ
cord-321607-3r736dnk	517	12	-	-	JJ
cord-321607-3r736dnk	517	13	canonical	canonical	JJ
cord-321607-3r736dnk	517	14	inflammasome	inflammasome	NN
cord-321607-3r736dnk	517	15	activation	activation	NN
cord-321607-3r736dnk	517	16	targets	target	NNS
cord-321607-3r736dnk	517	17	caspase-11	caspase-11	XX
cord-321607-3r736dnk	518	1	Picornavirus	Picornavirus	NNP
cord-321607-3r736dnk	518	2	entry	entry	NN
cord-321607-3r736dnk	519	1	How	how	WRB
cord-321607-3r736dnk	519	2	hepatitis	hepatitis	NNP
cord-321607-3r736dnk	519	3	c	c	NN
cord-321607-3r736dnk	519	4	virus	virus	NN
cord-321607-3r736dnk	519	5	invades	invade	VBZ
cord-321607-3r736dnk	519	6	hepatocytes	hepatocyte	NNS
cord-321607-3r736dnk	519	7	:	:	:
cord-321607-3r736dnk	520	1	The	the	DT
cord-321607-3r736dnk	520	2	mystery	mystery	NN
cord-321607-3r736dnk	520	3	of	of	IN
cord-321607-3r736dnk	520	4	viral	viral	JJ
cord-321607-3r736dnk	520	5	entry	entry	NN
cord-321607-3r736dnk	520	6	Critical	critical	JJ
cord-321607-3r736dnk	520	7	role	role	NN
cord-321607-3r736dnk	520	8	of	of	IN
cord-321607-3r736dnk	520	9	an	an	DT
cord-321607-3r736dnk	520	10	antiviral	antiviral	JJ
cord-321607-3r736dnk	520	11	stress	stress	NN
cord-321607-3r736dnk	520	12	granule	granule	NN
cord-321607-3r736dnk	520	13	containing	contain	VBG
cord-321607-3r736dnk	520	14	RIG	rig	NN
cord-321607-3r736dnk	520	15	-	-	:
cord-321607-3r736dnk	520	16	I	I	NNP
cord-321607-3r736dnk	520	17	and	and	CC
cord-321607-3r736dnk	520	18	PKR	PKR	NNP
cord-321607-3r736dnk	520	19	in	in	IN
cord-321607-3r736dnk	520	20	viral	viral	JJ
cord-321607-3r736dnk	520	21	detection	detection	NN
cord-321607-3r736dnk	520	22	and	and	CC
cord-321607-3r736dnk	520	23	innate	innate	JJ
cord-321607-3r736dnk	520	24	immunity	immunity	NN
cord-321607-3r736dnk	521	1	DHX36	DHX36	NNP
cord-321607-3r736dnk	521	2	enhances	enhance	VBZ
cord-321607-3r736dnk	521	3	RIG	rig	NN
cord-321607-3r736dnk	521	4	-	-	:
cord-321607-3r736dnk	521	5	I	i	NN
cord-321607-3r736dnk	521	6	signaling	signal	VBG
cord-321607-3r736dnk	521	7	by	by	IN
cord-321607-3r736dnk	521	8	facilitating	facilitate	VBG
cord-321607-3r736dnk	521	9	PKR	PKR	NNP
cord-321607-3r736dnk	521	10	-	-	HYPH
cord-321607-3r736dnk	521	11	mediated	mediate	VBN
cord-321607-3r736dnk	521	12	antiviral	antiviral	JJ
cord-321607-3r736dnk	521	13	stress	stress	NN
cord-321607-3r736dnk	521	14	granule	granule	NN
cord-321607-3r736dnk	521	15	formation	formation	NN
cord-321607-3r736dnk	521	16	New	new	JJ
cord-321607-3r736dnk	521	17	insights	insight	NNS
cord-321607-3r736dnk	521	18	into	into	IN
cord-321607-3r736dnk	521	19	the	the	DT
cord-321607-3r736dnk	521	20	regulation	regulation	NN
cord-321607-3r736dnk	521	21	of	of	IN
cord-321607-3r736dnk	521	22	signalling	signal	VBG
cord-321607-3r736dnk	521	23	by	by	IN
cord-321607-3r736dnk	521	24	Toll	toll	NN
cord-321607-3r736dnk	521	25	-	-	HYPH
cord-321607-3r736dnk	521	26	like	like	JJ
cord-321607-3r736dnk	521	27	receptors	receptor	NNS
cord-321607-3r736dnk	521	28	and	and	CC
cord-321607-3r736dnk	521	29	NOD	nod	NN
cord-321607-3r736dnk	521	30	-	-	HYPH
cord-321607-3r736dnk	521	31	like	like	JJ
cord-321607-3r736dnk	521	32	receptors	receptor	NNS
cord-321607-3r736dnk	521	33	Acknowledgments	acknowledgment	NNS
cord-321607-3r736dnk	522	1	:	:	:
cord-321607-3r736dnk	522	2	This	this	DT
cord-321607-3r736dnk	522	3	work	work	NN
cord-321607-3r736dnk	522	4	was	be	VBD
cord-321607-3r736dnk	522	5	supported	support	VBN
cord-321607-3r736dnk	522	6	by	by	IN
cord-321607-3r736dnk	522	7	the	the	DT
cord-321607-3r736dnk	522	8	Veterans	Veterans	NNPS
cord-321607-3r736dnk	522	9	Affairs	Affairs	NNPS
cord-321607-3r736dnk	522	10	VISN5	VISN5	NNP
cord-321607-3r736dnk	522	11	Pilot	Pilot	NNP
cord-321607-3r736dnk	522	12	Award	Award	NNP
cord-321607-3r736dnk	522	13	(	(	-LRB-
cord-321607-3r736dnk	522	14	Heather	Heather	NNP
cord-321607-3r736dnk	522	15	J	J	NNP
cord-321607-3r736dnk	522	16	Ezelle	Ezelle	NNP
cord-321607-3r736dnk	522	17	)	)	-RRB-
cord-321607-3r736dnk	522	18	,	,	,
cord-321607-3r736dnk	522	19	National	National	NNP
cord-321607-3r736dnk	522	20	Institutes	Institutes	NNPS
cord-321607-3r736dnk	522	21	of	of	IN
cord-321607-3r736dnk	522	22	Health	Health	NNP
cord-321607-3r736dnk	523	1	Grant	Grant	NNP
cord-321607-3r736dnk	523	2	AI089518	AI089518	NNP
cord-321607-3r736dnk	523	3	(	(	-LRB-
cord-321607-3r736dnk	523	4	Krishnamurthy	Krishnamurthy	NNP
cord-321607-3r736dnk	523	5	Malathi	Malathi	NNP
cord-321607-3r736dnk	523	6	)	)	-RRB-
cord-321607-3r736dnk	523	7	and	and	CC
cord-321607-3r736dnk	524	1	startup	startup	NN
cord-321607-3r736dnk	524	2	funds	fund	NNS
cord-321607-3r736dnk	524	3	from	from	IN
cord-321607-3r736dnk	524	4	University	University	NNP
cord-321607-3r736dnk	524	5	of	of	IN
cord-321607-3r736dnk	524	6	Toledo	Toledo	NNP
cord-321607-3r736dnk	524	7	(	(	-LRB-
cord-321607-3r736dnk	524	8	Krishnamurthy	Krishnamurthy	NNP
cord-321607-3r736dnk	524	9	Malathi	Malathi	NNP
cord-321607-3r736dnk	524	10	,	,	,
cord-321607-3r736dnk	524	11	Toledo	Toledo	NNP
cord-321607-3r736dnk	524	12	,	,	,
cord-321607-3r736dnk	524	13	OH	oh	UH
cord-321607-3r736dnk	524	14	,	,	,
cord-321607-3r736dnk	524	15	USA	USA	NNP
cord-321607-3r736dnk	524	16	)	)	-RRB-
cord-321607-3r736dnk	524	17	.	.	.
cord-321607-3r736dnk	525	1	We	-PRON-	PRP
cord-321607-3r736dnk	525	2	thank	thank	VBP
cord-321607-3r736dnk	525	3	Robert	Robert	NNP
cord-321607-3r736dnk	525	4	Silverman	Silverman	NNP
cord-321607-3r736dnk	525	5	and	and	CC
cord-321607-3r736dnk	525	6	Gerald	Gerald	NNP
cord-321607-3r736dnk	525	7	Radziwill	Radziwill	NNP
cord-321607-3r736dnk	525	8	for	for	IN
cord-321607-3r736dnk	525	9	generously	generously	RB
cord-321607-3r736dnk	525	10	providing	provide	VBG
cord-321607-3r736dnk	525	11	RNase	RNase	NNP
cord-321607-3r736dnk	525	12	-	-	HYPH
cord-321607-3r736dnk	525	13	L	l	NN
cord-321607-3r736dnk	525	14	and	and	CC
cord-321607-3r736dnk	525	15	LNX	LNX	NNP
cord-321607-3r736dnk	525	16	deletion	deletion	NN
cord-321607-3r736dnk	525	17	constructs	construct	NNS
cord-321607-3r736dnk	525	18	,	,	,
cord-321607-3r736dnk	525	19	respectively	respectively	RB
cord-321607-3r736dnk	525	20	.	.	.
cord-321607-3r736dnk	526	1	The	the	DT
cord-321607-3r736dnk	526	2	authors	author	NNS
cord-321607-3r736dnk	526	3	declare	declare	VBP
cord-321607-3r736dnk	526	4	no	no	DT
cord-321607-3r736dnk	526	5	conflict	conflict	NN
cord-321607-3r736dnk	526	6	of	of	IN
cord-321607-3r736dnk	526	7	interest	interest	NN
cord-321607-3r736dnk	526	8	.	.	.