id	sid	tid	token	lemma	pos
cord-323756-atnrw9ew	1	1	key	key	NN
cord-323756-atnrw9ew	1	2	:	:	:
cord-323756-atnrw9ew	1	3	cord-323756-atnrw9ew	cord-323756-atnrw9ew	XX
cord-323756-atnrw9ew	2	1	authors	author	NNS
cord-323756-atnrw9ew	2	2	:	:	:
cord-323756-atnrw9ew	2	3	Vabret	Vabret	NNP
cord-323756-atnrw9ew	2	4	,	,	,
cord-323756-atnrw9ew	2	5	Nicolas	Nicolas	NNP
cord-323756-atnrw9ew	2	6	;	;	:
cord-323756-atnrw9ew	3	1	Blander	bland	JJR
cord-323756-atnrw9ew	3	2	,	,	,
cord-323756-atnrw9ew	3	3	J.	J.	NNP
cord-323756-atnrw9ew	3	4	Magarian	Magarian	NNP
cord-323756-atnrw9ew	3	5	title	title	NN
cord-323756-atnrw9ew	3	6	:	:	:
cord-323756-atnrw9ew	3	7	Sensing	Sensing	NNP
cord-323756-atnrw9ew	3	8	Microbial	Microbial	NNP
cord-323756-atnrw9ew	3	9	RNA	RNA	NNP
cord-323756-atnrw9ew	3	10	in	in	IN
cord-323756-atnrw9ew	3	11	the	the	DT
cord-323756-atnrw9ew	3	12	Cytosol	Cytosol	NNP
cord-323756-atnrw9ew	3	13	date	date	NN
cord-323756-atnrw9ew	3	14	:	:	:
cord-323756-atnrw9ew	3	15	2013	2013	CD
cord-323756-atnrw9ew	3	16	-	-	SYM
cord-323756-atnrw9ew	3	17	12	12	CD
cord-323756-atnrw9ew	3	18	-	-	SYM
cord-323756-atnrw9ew	3	19	25	25	CD
cord-323756-atnrw9ew	3	20	journal	journal	NN
cord-323756-atnrw9ew	3	21	:	:	:
cord-323756-atnrw9ew	4	1	Front	Front	NNP
cord-323756-atnrw9ew	4	2	Immunol	Immunol	NNP
cord-323756-atnrw9ew	4	3	DOI	doi	NN
cord-323756-atnrw9ew	4	4	:	:	:
cord-323756-atnrw9ew	5	1	10.3389/	10.3389/	CD
cord-323756-atnrw9ew	6	1	fimmu.2013.00468	fimmu.2013.00468	CD
cord-323756-atnrw9ew	6	2	sha	sha	NNP
cord-323756-atnrw9ew	6	3	:	:	:
cord-323756-atnrw9ew	7	1	575aa2758f4a3c952d7cd9ab031eb42b25a87a96	575aa2758f4a3c952d7cd9ab031eb42b25a87a96	CD
cord-323756-atnrw9ew	7	2	doc_id	doc_id	CD
cord-323756-atnrw9ew	7	3	:	:	:
cord-323756-atnrw9ew	7	4	323756	323756	CD
cord-323756-atnrw9ew	7	5	cord_uid	cord_uid	NNS
cord-323756-atnrw9ew	7	6	:	:	:
cord-323756-atnrw9ew	8	1	atnrw9ew	atnrw9ew	RB
cord-323756-atnrw9ew	9	1	The	the	DT
cord-323756-atnrw9ew	9	2	innate	innate	JJ
cord-323756-atnrw9ew	9	3	immune	immune	JJ
cord-323756-atnrw9ew	9	4	system	system	NN
cord-323756-atnrw9ew	9	5	faces	face	VBZ
cord-323756-atnrw9ew	9	6	the	the	DT
cord-323756-atnrw9ew	9	7	difficult	difficult	JJ
cord-323756-atnrw9ew	9	8	task	task	NN
cord-323756-atnrw9ew	9	9	of	of	IN
cord-323756-atnrw9ew	9	10	keeping	keep	VBG
cord-323756-atnrw9ew	9	11	a	a	DT
cord-323756-atnrw9ew	9	12	fine	fine	JJ
cord-323756-atnrw9ew	9	13	balance	balance	NN
cord-323756-atnrw9ew	9	14	between	between	IN
cord-323756-atnrw9ew	9	15	sensitive	sensitive	JJ
cord-323756-atnrw9ew	9	16	detection	detection	NN
cord-323756-atnrw9ew	9	17	of	of	IN
cord-323756-atnrw9ew	9	18	microbial	microbial	JJ
cord-323756-atnrw9ew	9	19	presence	presence	NN
cord-323756-atnrw9ew	9	20	and	and	CC
cord-323756-atnrw9ew	9	21	avoidance	avoidance	NN
cord-323756-atnrw9ew	9	22	of	of	IN
cord-323756-atnrw9ew	9	23	autoimmunity	autoimmunity	NN
cord-323756-atnrw9ew	9	24	.	.	.
cord-323756-atnrw9ew	10	1	To	to	IN
cord-323756-atnrw9ew	10	2	this	this	DT
cord-323756-atnrw9ew	10	3	aim	aim	NN
cord-323756-atnrw9ew	10	4	,	,	,
cord-323756-atnrw9ew	10	5	key	key	JJ
cord-323756-atnrw9ew	10	6	mechanisms	mechanism	NNS
cord-323756-atnrw9ew	10	7	of	of	IN
cord-323756-atnrw9ew	10	8	innate	innate	JJ
cord-323756-atnrw9ew	10	9	responses	response	NNS
cord-323756-atnrw9ew	10	10	rely	rely	VBP
cord-323756-atnrw9ew	10	11	on	on	IN
cord-323756-atnrw9ew	10	12	isolation	isolation	NN
cord-323756-atnrw9ew	10	13	of	of	IN
cord-323756-atnrw9ew	10	14	pathogens	pathogen	NNS
cord-323756-atnrw9ew	10	15	in	in	IN
cord-323756-atnrw9ew	10	16	specialized	specialized	JJ
cord-323756-atnrw9ew	10	17	subcellular	subcellular	JJ
cord-323756-atnrw9ew	10	18	compartments	compartment	NNS
cord-323756-atnrw9ew	10	19	,	,	,
cord-323756-atnrw9ew	10	20	or	or	CC
cord-323756-atnrw9ew	10	21	sensing	sensing	NN
cord-323756-atnrw9ew	10	22	of	of	IN
cord-323756-atnrw9ew	10	23	specific	specific	JJ
cord-323756-atnrw9ew	10	24	microbial	microbial	JJ
cord-323756-atnrw9ew	10	25	patterns	pattern	NNS
cord-323756-atnrw9ew	10	26	absent	absent	JJ
cord-323756-atnrw9ew	10	27	from	from	IN
cord-323756-atnrw9ew	10	28	the	the	DT
cord-323756-atnrw9ew	10	29	host	host	NN
cord-323756-atnrw9ew	10	30	.	.	.
cord-323756-atnrw9ew	11	1	Efficient	efficient	JJ
cord-323756-atnrw9ew	11	2	detection	detection	NN
cord-323756-atnrw9ew	11	3	of	of	IN
cord-323756-atnrw9ew	11	4	foreign	foreign	JJ
cord-323756-atnrw9ew	11	5	RNA	RNA	NNP
cord-323756-atnrw9ew	11	6	in	in	IN
cord-323756-atnrw9ew	11	7	the	the	DT
cord-323756-atnrw9ew	11	8	cytosol	cytosol	NN
cord-323756-atnrw9ew	11	9	requires	require	VBZ
cord-323756-atnrw9ew	11	10	an	an	DT
cord-323756-atnrw9ew	11	11	additional	additional	JJ
cord-323756-atnrw9ew	11	12	layer	layer	NN
cord-323756-atnrw9ew	11	13	of	of	IN
cord-323756-atnrw9ew	11	14	complexity	complexity	NN
cord-323756-atnrw9ew	11	15	from	from	IN
cord-323756-atnrw9ew	11	16	the	the	DT
cord-323756-atnrw9ew	11	17	immune	immune	JJ
cord-323756-atnrw9ew	11	18	system	system	NN
cord-323756-atnrw9ew	11	19	.	.	.
cord-323756-atnrw9ew	12	1	In	in	IN
cord-323756-atnrw9ew	12	2	this	this	DT
cord-323756-atnrw9ew	12	3	particular	particular	JJ
cord-323756-atnrw9ew	12	4	case	case	NN
cord-323756-atnrw9ew	12	5	,	,	,
cord-323756-atnrw9ew	12	6	innate	innate	JJ
cord-323756-atnrw9ew	12	7	sensors	sensor	NNS
cord-323756-atnrw9ew	12	8	should	should	MD
cord-323756-atnrw9ew	12	9	be	be	VB
cord-323756-atnrw9ew	12	10	able	able	JJ
cord-323756-atnrw9ew	12	11	to	to	TO
cord-323756-atnrw9ew	12	12	distinguish	distinguish	VB
cord-323756-atnrw9ew	12	13	self	self	NN
cord-323756-atnrw9ew	12	14	and	and	CC
cord-323756-atnrw9ew	12	15	non	non	JJ
cord-323756-atnrw9ew	12	16	-	-	JJ
cord-323756-atnrw9ew	12	17	self	self	JJ
cord-323756-atnrw9ew	12	18	molecules	molecule	NNS
cord-323756-atnrw9ew	12	19	that	that	WDT
cord-323756-atnrw9ew	12	20	share	share	VBP
cord-323756-atnrw9ew	12	21	several	several	JJ
cord-323756-atnrw9ew	12	22	similar	similar	JJ
cord-323756-atnrw9ew	12	23	properties	property	NNS
cord-323756-atnrw9ew	12	24	.	.	.
cord-323756-atnrw9ew	13	1	In	in	IN
cord-323756-atnrw9ew	13	2	this	this	DT
cord-323756-atnrw9ew	13	3	review	review	NN
cord-323756-atnrw9ew	13	4	,	,	,
cord-323756-atnrw9ew	13	5	we	-PRON-	PRP
cord-323756-atnrw9ew	13	6	discuss	discuss	VBP
cord-323756-atnrw9ew	13	7	this	this	DT
cord-323756-atnrw9ew	13	8	interplay	interplay	NN
cord-323756-atnrw9ew	13	9	between	between	IN
cord-323756-atnrw9ew	13	10	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	13	11	pattern	pattern	NN
cord-323756-atnrw9ew	13	12	recognition	recognition	NN
cord-323756-atnrw9ew	13	13	receptors	receptor	NNS
cord-323756-atnrw9ew	13	14	and	and	CC
cord-323756-atnrw9ew	13	15	the	the	DT
cord-323756-atnrw9ew	13	16	microbial	microbial	JJ
cord-323756-atnrw9ew	13	17	RNA	RNA	NNP
cord-323756-atnrw9ew	13	18	they	-PRON-	PRP
cord-323756-atnrw9ew	13	19	detect	detect	VBP
cord-323756-atnrw9ew	13	20	.	.	.
cord-323756-atnrw9ew	14	1	We	-PRON-	PRP
cord-323756-atnrw9ew	14	2	describe	describe	VBP
cord-323756-atnrw9ew	14	3	how	how	WRB
cord-323756-atnrw9ew	14	4	microbial	microbial	JJ
cord-323756-atnrw9ew	14	5	RNAs	rna	NNS
cord-323756-atnrw9ew	14	6	gain	gain	VBP
cord-323756-atnrw9ew	14	7	access	access	NN
cord-323756-atnrw9ew	14	8	to	to	IN
cord-323756-atnrw9ew	14	9	the	the	DT
cord-323756-atnrw9ew	14	10	cytosol	cytosol	NN
cord-323756-atnrw9ew	14	11	,	,	,
cord-323756-atnrw9ew	14	12	which	which	WDT
cord-323756-atnrw9ew	14	13	receptors	receptor	NNS
cord-323756-atnrw9ew	14	14	they	-PRON-	PRP
cord-323756-atnrw9ew	14	15	activate	activate	VBP
cord-323756-atnrw9ew	14	16	and	and	CC
cord-323756-atnrw9ew	14	17	counter	counter	NN
cord-323756-atnrw9ew	14	18	-	-	NNS
cord-323756-atnrw9ew	14	19	strategies	strategy	NNS
cord-323756-atnrw9ew	14	20	developed	develop	VBN
cord-323756-atnrw9ew	14	21	by	by	IN
cord-323756-atnrw9ew	14	22	microorganisms	microorganism	NNS
cord-323756-atnrw9ew	14	23	to	to	TO
cord-323756-atnrw9ew	14	24	avoid	avoid	VB
cord-323756-atnrw9ew	14	25	this	this	DT
cord-323756-atnrw9ew	14	26	response	response	NN
cord-323756-atnrw9ew	14	27	.	.	.
cord-323756-atnrw9ew	15	1	When	when	WRB
cord-323756-atnrw9ew	15	2	Janeway	Janeway	NNP
cord-323756-atnrw9ew	15	3	formulated	formulate	VBD
cord-323756-atnrw9ew	15	4	the	the	DT
cord-323756-atnrw9ew	15	5	theory	theory	NN
cord-323756-atnrw9ew	15	6	of	of	IN
cord-323756-atnrw9ew	15	7	pattern	pattern	NN
cord-323756-atnrw9ew	15	8	recognition	recognition	NN
cord-323756-atnrw9ew	15	9	in	in	IN
cord-323756-atnrw9ew	15	10	1989	1989	CD
cord-323756-atnrw9ew	15	11	,	,	,
cord-323756-atnrw9ew	15	12	he	-PRON-	PRP
cord-323756-atnrw9ew	15	13	proposed	propose	VBD
cord-323756-atnrw9ew	15	14	that	that	IN
cord-323756-atnrw9ew	15	15	host	host	NN
cord-323756-atnrw9ew	15	16	cells	cell	NNS
cord-323756-atnrw9ew	15	17	could	could	MD
cord-323756-atnrw9ew	15	18	sense	sense	VB
cord-323756-atnrw9ew	15	19	microbial	microbial	JJ
cord-323756-atnrw9ew	15	20	infection	infection	NN
cord-323756-atnrw9ew	15	21	owing	owe	VBG
cord-323756-atnrw9ew	15	22	to	to	IN
cord-323756-atnrw9ew	15	23	receptors	receptor	NNS
cord-323756-atnrw9ew	15	24	able	able	JJ
cord-323756-atnrw9ew	15	25	to	to	TO
cord-323756-atnrw9ew	15	26	recognize	recognize	VB
cord-323756-atnrw9ew	15	27	invariant	invariant	JJ
cord-323756-atnrw9ew	15	28	molecular	molecular	JJ
cord-323756-atnrw9ew	15	29	structures	structure	NNS
cord-323756-atnrw9ew	15	30	defined	define	VBN
cord-323756-atnrw9ew	15	31	as	as	IN
cord-323756-atnrw9ew	15	32	pathogen	pathogen	NN
cord-323756-atnrw9ew	15	33	-	-	HYPH
cord-323756-atnrw9ew	15	34	associated	associate	VBN
cord-323756-atnrw9ew	15	35	molecular	molecular	JJ
cord-323756-atnrw9ew	15	36	patterns	pattern	NNS
cord-323756-atnrw9ew	15	37	(	(	-LRB-
cord-323756-atnrw9ew	15	38	PAMPs	pamp	NNS
cord-323756-atnrw9ew	15	39	)	)	-RRB-
cord-323756-atnrw9ew	15	40	.	.	.
cord-323756-atnrw9ew	16	1	These	these	DT
cord-323756-atnrw9ew	16	2	patterns	pattern	NNS
cord-323756-atnrw9ew	16	3	would	would	MD
cord-323756-atnrw9ew	16	4	be	be	VB
cord-323756-atnrw9ew	16	5	present	present	JJ
cord-323756-atnrw9ew	16	6	in	in	IN
cord-323756-atnrw9ew	16	7	groups	group	NNS
cord-323756-atnrw9ew	16	8	of	of	IN
cord-323756-atnrw9ew	16	9	pathogens	pathogen	NNS
cord-323756-atnrw9ew	16	10	,	,	,
cord-323756-atnrw9ew	16	11	but	but	CC
cord-323756-atnrw9ew	16	12	absent	absent	JJ
cord-323756-atnrw9ew	16	13	in	in	IN
cord-323756-atnrw9ew	16	14	the	the	DT
cord-323756-atnrw9ew	16	15	host	host	NN
cord-323756-atnrw9ew	16	16	(	(	-LRB-
cord-323756-atnrw9ew	16	17	1	1	CD
cord-323756-atnrw9ew	16	18	)	)	-RRB-
cord-323756-atnrw9ew	16	19	.	.	.
cord-323756-atnrw9ew	17	1	Years	year	NNS
cord-323756-atnrw9ew	17	2	later	later	RB
cord-323756-atnrw9ew	17	3	,	,	,
cord-323756-atnrw9ew	17	4	Janeway	Janeway	NNP
cord-323756-atnrw9ew	17	5	and	and	CC
cord-323756-atnrw9ew	17	6	Medzhitov	Medzhitov	NNP
cord-323756-atnrw9ew	17	7	described	describe	VBD
cord-323756-atnrw9ew	17	8	the	the	DT
cord-323756-atnrw9ew	17	9	activity	activity	NN
cord-323756-atnrw9ew	17	10	of	of	IN
cord-323756-atnrw9ew	17	11	the	the	DT
cord-323756-atnrw9ew	17	12	first	first	JJ
cord-323756-atnrw9ew	17	13	mammalian	mammalian	JJ
cord-323756-atnrw9ew	17	14	member	member	NN
cord-323756-atnrw9ew	17	15	of	of	IN
cord-323756-atnrw9ew	17	16	the	the	DT
cord-323756-atnrw9ew	17	17	Toll	Toll	NNP
cord-323756-atnrw9ew	17	18	-	-	HYPH
cord-323756-atnrw9ew	17	19	like	like	JJ
cord-323756-atnrw9ew	17	20	receptor	receptor	NN
cord-323756-atnrw9ew	17	21	(	(	-LRB-
cord-323756-atnrw9ew	17	22	TLR	TLR	NNP
cord-323756-atnrw9ew	17	23	)	)	-RRB-
cord-323756-atnrw9ew	17	24	family	family	NN
cord-323756-atnrw9ew	17	25	,	,	,
cord-323756-atnrw9ew	17	26	Toll	Toll	NNP
cord-323756-atnrw9ew	17	27	-	-	HYPH
cord-323756-atnrw9ew	17	28	like	like	JJ
cord-323756-atnrw9ew	17	29	receptor	receptor	NN
cord-323756-atnrw9ew	17	30	4	4	CD
cord-323756-atnrw9ew	17	31	(	(	-LRB-
cord-323756-atnrw9ew	17	32	2	2	CD
cord-323756-atnrw9ew	17	33	)	)	-RRB-
cord-323756-atnrw9ew	17	34	.	.	.
cord-323756-atnrw9ew	18	1	TLRs	TLRs	NNP
cord-323756-atnrw9ew	18	2	comprise	comprise	VBP
cord-323756-atnrw9ew	18	3	a	a	DT
cord-323756-atnrw9ew	18	4	family	family	NN
cord-323756-atnrw9ew	18	5	of	of	IN
cord-323756-atnrw9ew	18	6	transmembrane	transmembrane	NN
cord-323756-atnrw9ew	18	7	proteins	protein	NNS
cord-323756-atnrw9ew	18	8	able	able	JJ
cord-323756-atnrw9ew	18	9	to	to	TO
cord-323756-atnrw9ew	18	10	recognize	recognize	VB
cord-323756-atnrw9ew	18	11	conserved	conserve	VBN
cord-323756-atnrw9ew	18	12	microbial	microbial	JJ
cord-323756-atnrw9ew	18	13	features	feature	NNS
cord-323756-atnrw9ew	18	14	and	and	CC
cord-323756-atnrw9ew	18	15	activate	activate	VB
cord-323756-atnrw9ew	18	16	the	the	DT
cord-323756-atnrw9ew	18	17	immune	immune	JJ
cord-323756-atnrw9ew	18	18	response	response	NN
cord-323756-atnrw9ew	18	19	(	(	-LRB-
cord-323756-atnrw9ew	18	20	3	3	CD
cord-323756-atnrw9ew	18	21	)	)	-RRB-
cord-323756-atnrw9ew	18	22	.	.	.
cord-323756-atnrw9ew	19	1	Once	once	RB
cord-323756-atnrw9ew	19	2	activated	activate	VBN
cord-323756-atnrw9ew	19	3	,	,	,
cord-323756-atnrw9ew	19	4	TLRs	tlr	NNS
cord-323756-atnrw9ew	19	5	and	and	CC
cord-323756-atnrw9ew	19	6	others	other	NNS
cord-323756-atnrw9ew	19	7	pattern	pattern	VBP
cord-323756-atnrw9ew	19	8	recognition	recognition	NN
cord-323756-atnrw9ew	19	9	receptors	receptor	NNS
cord-323756-atnrw9ew	19	10	(	(	-LRB-
cord-323756-atnrw9ew	19	11	PRRs	PRRs	NNP
cord-323756-atnrw9ew	19	12	)	)	-RRB-
cord-323756-atnrw9ew	19	13	initiate	initiate	VBP
cord-323756-atnrw9ew	19	14	several	several	JJ
cord-323756-atnrw9ew	19	15	intracellular	intracellular	JJ
cord-323756-atnrw9ew	19	16	pathways	pathway	NNS
cord-323756-atnrw9ew	19	17	,	,	,
cord-323756-atnrw9ew	19	18	including	include	VBG
cord-323756-atnrw9ew	19	19	those	those	DT
cord-323756-atnrw9ew	19	20	mediated	mediate	VBN
cord-323756-atnrw9ew	19	21	by	by	IN
cord-323756-atnrw9ew	19	22	nuclear	nuclear	JJ
cord-323756-atnrw9ew	19	23	factor	factor	NN
cord-323756-atnrw9ew	19	24	-	-	:
cord-323756-atnrw9ew	19	25	κB	κB	NNP
cord-323756-atnrw9ew	19	26	(	(	-LRB-
cord-323756-atnrw9ew	19	27	NF	nf	NN
cord-323756-atnrw9ew	19	28	-	-	HYPH
cord-323756-atnrw9ew	19	29	κB	κB	NNP
cord-323756-atnrw9ew	19	30	)	)	-RRB-
cord-323756-atnrw9ew	19	31	,	,	,
cord-323756-atnrw9ew	19	32	mitogen	mitogen	NN
cord-323756-atnrw9ew	19	33	-	-	HYPH
cord-323756-atnrw9ew	19	34	activated	activate	VBN
cord-323756-atnrw9ew	19	35	protein	protein	NN
cord-323756-atnrw9ew	19	36	kinases	kinase	NNS
cord-323756-atnrw9ew	19	37	(	(	-LRB-
cord-323756-atnrw9ew	19	38	MAPKs	MAPKs	NNP
cord-323756-atnrw9ew	19	39	)	)	-RRB-
cord-323756-atnrw9ew	19	40	,	,	,
cord-323756-atnrw9ew	19	41	and	and	CC
cord-323756-atnrw9ew	19	42	interferon	interferon	NN
cord-323756-atnrw9ew	19	43	regulatory	regulatory	JJ
cord-323756-atnrw9ew	19	44	factors	factor	NNS
cord-323756-atnrw9ew	19	45	(	(	-LRB-
cord-323756-atnrw9ew	19	46	IRFs	IRFs	NNP
cord-323756-atnrw9ew	19	47	)	)	-RRB-
cord-323756-atnrw9ew	19	48	.	.	.
cord-323756-atnrw9ew	20	1	Another	another	DT
cord-323756-atnrw9ew	20	2	outcome	outcome	NN
cord-323756-atnrw9ew	20	3	of	of	IN
cord-323756-atnrw9ew	20	4	activation	activation	NN
cord-323756-atnrw9ew	20	5	of	of	IN
cord-323756-atnrw9ew	20	6	distinct	distinct	JJ
cord-323756-atnrw9ew	20	7	members	member	NNS
cord-323756-atnrw9ew	20	8	of	of	IN
cord-323756-atnrw9ew	20	9	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	20	10	PRRs	PRRs	NNP
cord-323756-atnrw9ew	20	11	is	be	VBZ
cord-323756-atnrw9ew	20	12	their	-PRON-	PRP$
cord-323756-atnrw9ew	20	13	oligomerization	oligomerization	NN
cord-323756-atnrw9ew	20	14	into	into	IN
cord-323756-atnrw9ew	20	15	multimeric	multimeric	JJ
cord-323756-atnrw9ew	20	16	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	20	17	structures	structure	NNS
cord-323756-atnrw9ew	20	18	called	call	VBD
cord-323756-atnrw9ew	20	19	inflammasomes	inflammasome	NNS
cord-323756-atnrw9ew	20	20	,	,	,
cord-323756-atnrw9ew	20	21	which	which	WDT
cord-323756-atnrw9ew	20	22	activate	activate	VBP
cord-323756-atnrw9ew	20	23	the	the	DT
cord-323756-atnrw9ew	20	24	cysteine	cysteine	NN
cord-323756-atnrw9ew	20	25	protease	protease	NN
cord-323756-atnrw9ew	20	26	caspase-1	caspase-1	NNP
cord-323756-atnrw9ew	20	27	,	,	,
cord-323756-atnrw9ew	20	28	subsequently	subsequently	RB
cord-323756-atnrw9ew	20	29	leading	lead	VBG
cord-323756-atnrw9ew	20	30	to	to	IN
cord-323756-atnrw9ew	20	31	the	the	DT
cord-323756-atnrw9ew	20	32	production	production	NN
cord-323756-atnrw9ew	20	33	of	of	IN
cord-323756-atnrw9ew	20	34	biologically	biologically	RB
cord-323756-atnrw9ew	20	35	active	active	JJ
cord-323756-atnrw9ew	20	36	forms	form	NNS
cord-323756-atnrw9ew	20	37	of	of	IN
cord-323756-atnrw9ew	20	38	pro	pro	JJ
cord-323756-atnrw9ew	20	39	-	-	JJ
cord-323756-atnrw9ew	20	40	inflammatory	inflammatory	JJ
cord-323756-atnrw9ew	20	41	cytokines	cytokine	NNS
cord-323756-atnrw9ew	20	42	(	(	-LRB-
cord-323756-atnrw9ew	20	43	4	4	CD
cord-323756-atnrw9ew	20	44	)	)	-RRB-
cord-323756-atnrw9ew	20	45	.	.	.
cord-323756-atnrw9ew	21	1	Initially	initially	RB
cord-323756-atnrw9ew	21	2	thought	think	VBD
cord-323756-atnrw9ew	21	3	to	to	TO
cord-323756-atnrw9ew	21	4	detect	detect	VB
cord-323756-atnrw9ew	21	5	exclusively	exclusively	RB
cord-323756-atnrw9ew	21	6	microbial	microbial	JJ
cord-323756-atnrw9ew	21	7	derived	derive	VBN
cord-323756-atnrw9ew	21	8	ligands	ligand	NNS
cord-323756-atnrw9ew	21	9	,	,	,
cord-323756-atnrw9ew	21	10	PRRs	prr	NNS
cord-323756-atnrw9ew	21	11	were	be	VBD
cord-323756-atnrw9ew	21	12	later	later	RB
cord-323756-atnrw9ew	21	13	shown	show	VBN
cord-323756-atnrw9ew	21	14	to	to	TO
cord-323756-atnrw9ew	21	15	recognize	recognize	VB
cord-323756-atnrw9ew	21	16	host	host	NN
cord-323756-atnrw9ew	21	17	derived	derive	VBN
cord-323756-atnrw9ew	21	18	danger	danger	NN
cord-323756-atnrw9ew	21	19	signals	signal	NNS
cord-323756-atnrw9ew	21	20	,	,	,
cord-323756-atnrw9ew	21	21	which	which	WDT
cord-323756-atnrw9ew	21	22	are	be	VBP
cord-323756-atnrw9ew	21	23	released	release	VBN
cord-323756-atnrw9ew	21	24	in	in	IN
cord-323756-atnrw9ew	21	25	response	response	NN
cord-323756-atnrw9ew	21	26	to	to	IN
cord-323756-atnrw9ew	21	27	stress	stress	NN
cord-323756-atnrw9ew	21	28	conditions	condition	NNS
cord-323756-atnrw9ew	21	29	such	such	JJ
cord-323756-atnrw9ew	21	30	as	as	IN
cord-323756-atnrw9ew	21	31	cellular	cellular	JJ
cord-323756-atnrw9ew	21	32	damage	damage	NN
cord-323756-atnrw9ew	21	33	or	or	CC
cord-323756-atnrw9ew	21	34	tissue	tissue	NN
cord-323756-atnrw9ew	21	35	injury	injury	NN
cord-323756-atnrw9ew	21	36	(	(	-LRB-
cord-323756-atnrw9ew	21	37	3	3	CD
cord-323756-atnrw9ew	21	38	)	)	-RRB-
cord-323756-atnrw9ew	21	39	.	.	.
cord-323756-atnrw9ew	22	1	Under	under	IN
cord-323756-atnrw9ew	22	2	normal	normal	JJ
cord-323756-atnrw9ew	22	3	physiological	physiological	JJ
cord-323756-atnrw9ew	22	4	conditions	condition	NNS
cord-323756-atnrw9ew	22	5	,	,	,
cord-323756-atnrw9ew	22	6	these	these	DT
cord-323756-atnrw9ew	22	7	ligands	ligand	NNS
cord-323756-atnrw9ew	22	8	are	be	VBP
cord-323756-atnrw9ew	22	9	not	not	RB
cord-323756-atnrw9ew	22	10	accessible	accessible	JJ
cord-323756-atnrw9ew	22	11	to	to	IN
cord-323756-atnrw9ew	22	12	their	-PRON-	PRP$
cord-323756-atnrw9ew	22	13	respective	respective	JJ
cord-323756-atnrw9ew	22	14	PRRs	prr	NNS
cord-323756-atnrw9ew	22	15	and	and	CC
cord-323756-atnrw9ew	22	16	do	do	VBP
cord-323756-atnrw9ew	22	17	not	not	RB
cord-323756-atnrw9ew	22	18	activate	activate	VB
cord-323756-atnrw9ew	22	19	the	the	DT
cord-323756-atnrw9ew	22	20	immune	immune	JJ
cord-323756-atnrw9ew	22	21	system	system	NN
cord-323756-atnrw9ew	22	22	.	.	.
cord-323756-atnrw9ew	23	1	Conversely	conversely	RB
cord-323756-atnrw9ew	23	2	,	,	,
cord-323756-atnrw9ew	23	3	it	-PRON-	PRP
cord-323756-atnrw9ew	23	4	was	be	VBD
cord-323756-atnrw9ew	23	5	first	first	RB
cord-323756-atnrw9ew	23	6	suggested	suggest	VBN
cord-323756-atnrw9ew	23	7	that	that	IN
cord-323756-atnrw9ew	23	8	self	self	NN
cord-323756-atnrw9ew	23	9	-	-	HYPH
cord-323756-atnrw9ew	23	10	DNA	dna	NN
cord-323756-atnrw9ew	23	11	artificially	artificially	RB
cord-323756-atnrw9ew	23	12	introduced	introduce	VBN
cord-323756-atnrw9ew	23	13	into	into	IN
cord-323756-atnrw9ew	23	14	the	the	DT
cord-323756-atnrw9ew	23	15	cytoplasm	cytoplasm	NN
cord-323756-atnrw9ew	23	16	by	by	IN
cord-323756-atnrw9ew	23	17	transfection	transfection	NN
cord-323756-atnrw9ew	23	18	could	could	MD
cord-323756-atnrw9ew	23	19	activate	activate	VB
cord-323756-atnrw9ew	23	20	NF	NF	NNP
cord-323756-atnrw9ew	23	21	-	-	HYPH
cord-323756-atnrw9ew	23	22	κB	κB	NNP
cord-323756-atnrw9ew	23	23	and	and	CC
cord-323756-atnrw9ew	23	24	the	the	DT
cord-323756-atnrw9ew	23	25	MAPK	MAPK	NNP
cord-323756-atnrw9ew	23	26	pathway	pathway	NN
cord-323756-atnrw9ew	23	27	(	(	-LRB-
cord-323756-atnrw9ew	23	28	5	5	CD
cord-323756-atnrw9ew	23	29	)	)	-RRB-
cord-323756-atnrw9ew	23	30	.	.	.
cord-323756-atnrw9ew	24	1	Evidence	evidence	NN
cord-323756-atnrw9ew	24	2	that	that	IN
cord-323756-atnrw9ew	24	3	any	any	DT
cord-323756-atnrw9ew	24	4	DNA	dna	NN
cord-323756-atnrw9ew	24	5	,	,	,
cord-323756-atnrw9ew	24	6	regardless	regardless	RB
cord-323756-atnrw9ew	24	7	of	of	IN
cord-323756-atnrw9ew	24	8	its	-PRON-	PRP$
cord-323756-atnrw9ew	24	9	origin	origin	NN
cord-323756-atnrw9ew	24	10	,	,	,
cord-323756-atnrw9ew	24	11	can	can	MD
cord-323756-atnrw9ew	24	12	engage	engage	VB
cord-323756-atnrw9ew	24	13	innate	innate	JJ
cord-323756-atnrw9ew	24	14	immune	immune	JJ
cord-323756-atnrw9ew	24	15	receptors	receptor	NNS
cord-323756-atnrw9ew	24	16	when	when	WRB
cord-323756-atnrw9ew	24	17	localized	localize	VBN
cord-323756-atnrw9ew	24	18	outside	outside	RB
cord-323756-atnrw9ew	24	19	of	of	IN
cord-323756-atnrw9ew	24	20	the	the	DT
cord-323756-atnrw9ew	24	21	nucleus	nucleus	NN
cord-323756-atnrw9ew	24	22	was	be	VBD
cord-323756-atnrw9ew	24	23	further	further	RB
cord-323756-atnrw9ew	24	24	confirmed	confirm	VBN
cord-323756-atnrw9ew	24	25	by	by	IN
cord-323756-atnrw9ew	24	26	the	the	DT
cord-323756-atnrw9ew	24	27	identification	identification	NN
cord-323756-atnrw9ew	24	28	of	of	IN
cord-323756-atnrw9ew	24	29	several	several	JJ
cord-323756-atnrw9ew	24	30	endosomal	endosomal	JJ
cord-323756-atnrw9ew	24	31	and	and	CC
cord-323756-atnrw9ew	24	32	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	24	33	DNA	dna	NN
cord-323756-atnrw9ew	24	34	sensors	sensor	NNS
cord-323756-atnrw9ew	24	35	[	[	-LRB-
cord-323756-atnrw9ew	24	36	reviewed	review	VBN
cord-323756-atnrw9ew	24	37	in	in	IN
cord-323756-atnrw9ew	24	38	Ref	Ref	NNP
cord-323756-atnrw9ew	24	39	.	.	.
cord-323756-atnrw9ew	25	1	(	(	-LRB-
cord-323756-atnrw9ew	25	2	6	6	LS
cord-323756-atnrw9ew	25	3	)	)	-RRB-
cord-323756-atnrw9ew	25	4	]	]	-RRB-
cord-323756-atnrw9ew	25	5	.	.	.
cord-323756-atnrw9ew	26	1	In	in	IN
cord-323756-atnrw9ew	26	2	contrast	contrast	NN
cord-323756-atnrw9ew	26	3	to	to	IN
cord-323756-atnrw9ew	26	4	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	26	5	DNA	DNA	NNP
cord-323756-atnrw9ew	26	6	,	,	,
cord-323756-atnrw9ew	26	7	RNA	RNA	NNP
cord-323756-atnrw9ew	26	8	sensing	sensing	NN
cord-323756-atnrw9ew	26	9	in	in	IN
cord-323756-atnrw9ew	26	10	the	the	DT
cord-323756-atnrw9ew	26	11	cytoplasm	cytoplasm	NN
cord-323756-atnrw9ew	26	12	raises	raise	VBZ
cord-323756-atnrw9ew	26	13	many	many	JJ
cord-323756-atnrw9ew	26	14	questions	question	NNS
cord-323756-atnrw9ew	26	15	on	on	IN
cord-323756-atnrw9ew	26	16	the	the	DT
cord-323756-atnrw9ew	26	17	mechanisms	mechanism	NNS
cord-323756-atnrw9ew	26	18	used	use	VBN
cord-323756-atnrw9ew	26	19	by	by	IN
cord-323756-atnrw9ew	26	20	the	the	DT
cord-323756-atnrw9ew	26	21	innate	innate	JJ
cord-323756-atnrw9ew	26	22	system	system	NN
cord-323756-atnrw9ew	26	23	to	to	TO
cord-323756-atnrw9ew	26	24	specifically	specifically	RB
cord-323756-atnrw9ew	26	25	distinguish	distinguish	VB
cord-323756-atnrw9ew	26	26	non	non	JJ
cord-323756-atnrw9ew	26	27	-	-	JJ
cord-323756-atnrw9ew	26	28	self	self	JJ
cord-323756-atnrw9ew	26	29	-	-	HYPH
cord-323756-atnrw9ew	26	30	RNA	RNA	NNP
cord-323756-atnrw9ew	26	31	from	from	IN
cord-323756-atnrw9ew	26	32	self	self	NN
cord-323756-atnrw9ew	26	33	-	-	HYPH
cord-323756-atnrw9ew	26	34	RNA	RNA	NNP
cord-323756-atnrw9ew	26	35	.	.	.
cord-323756-atnrw9ew	27	1	During	during	IN
cord-323756-atnrw9ew	27	2	infection	infection	NN
cord-323756-atnrw9ew	27	3	,	,	,
cord-323756-atnrw9ew	27	4	microbial	microbial	JJ
cord-323756-atnrw9ew	27	5	RNAs	rna	NNS
cord-323756-atnrw9ew	27	6	share	share	VBP
cord-323756-atnrw9ew	27	7	the	the	DT
cord-323756-atnrw9ew	27	8	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	27	9	cellular	cellular	JJ
cord-323756-atnrw9ew	27	10	compartment	compartment	NN
cord-323756-atnrw9ew	27	11	with	with	IN
cord-323756-atnrw9ew	27	12	several	several	JJ
cord-323756-atnrw9ew	27	13	host	host	NN
cord-323756-atnrw9ew	27	14	RNA	RNA	NNP
cord-323756-atnrw9ew	27	15	species	specie	NNS
cord-323756-atnrw9ew	27	16	,	,	,
cord-323756-atnrw9ew	27	17	including	include	VBG
cord-323756-atnrw9ew	27	18	messenger	messenger	NN
cord-323756-atnrw9ew	27	19	RNA	RNA	NNP
cord-323756-atnrw9ew	27	20	(	(	-LRB-
cord-323756-atnrw9ew	27	21	mRNA	mRNA	NNP
cord-323756-atnrw9ew	27	22	)	)	-RRB-
cord-323756-atnrw9ew	27	23	,	,	.
cord-323756-atnrw9ew	28	1	transfer	transfer	NN
cord-323756-atnrw9ew	28	2	RNA	RNA	NNP
cord-323756-atnrw9ew	28	3	(	(	-LRB-
cord-323756-atnrw9ew	28	4	tRNA	tRNA	NNP
cord-323756-atnrw9ew	28	5	)	)	-RRB-
cord-323756-atnrw9ew	28	6	,	,	,
cord-323756-atnrw9ew	28	7	ribosomal	ribosomal	NNP
cord-323756-atnrw9ew	28	8	RNA	RNA	NNP
cord-323756-atnrw9ew	28	9	(	(	-LRB-
cord-323756-atnrw9ew	28	10	rRNA	rRNA	NNP
cord-323756-atnrw9ew	28	11	)	)	-RRB-
cord-323756-atnrw9ew	28	12	,	,	,
cord-323756-atnrw9ew	28	13	microRNA	microRNA	NNP
cord-323756-atnrw9ew	28	14	,	,	,
cord-323756-atnrw9ew	28	15	and	and	CC
cord-323756-atnrw9ew	28	16	other	other	JJ
cord-323756-atnrw9ew	28	17	small	small	JJ
cord-323756-atnrw9ew	28	18	regulatory	regulatory	JJ
cord-323756-atnrw9ew	28	19	RNAs	rna	NNS
cord-323756-atnrw9ew	28	20	.	.	.
cord-323756-atnrw9ew	29	1	As	as	IN
cord-323756-atnrw9ew	29	2	a	a	DT
cord-323756-atnrw9ew	29	3	consequence	consequence	NN
cord-323756-atnrw9ew	29	4	,	,	,
cord-323756-atnrw9ew	29	5	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	29	6	sensors	sensor	NNS
cord-323756-atnrw9ew	29	7	must	must	MD
cord-323756-atnrw9ew	29	8	display	display	VB
cord-323756-atnrw9ew	29	9	a	a	DT
cord-323756-atnrw9ew	29	10	high	high	JJ
cord-323756-atnrw9ew	29	11	affinity	affinity	NN
cord-323756-atnrw9ew	29	12	for	for	IN
cord-323756-atnrw9ew	29	13	specific	specific	JJ
cord-323756-atnrw9ew	29	14	microbial	microbial	JJ
cord-323756-atnrw9ew	29	15	features	feature	NNS
cord-323756-atnrw9ew	29	16	to	to	TO
cord-323756-atnrw9ew	29	17	avoid	avoid	VB
cord-323756-atnrw9ew	29	18	activation	activation	NN
cord-323756-atnrw9ew	29	19	by	by	IN
cord-323756-atnrw9ew	29	20	host	host	NN
cord-323756-atnrw9ew	29	21	molecules	molecule	NNS
cord-323756-atnrw9ew	29	22	that	that	WDT
cord-323756-atnrw9ew	29	23	would	would	MD
cord-323756-atnrw9ew	29	24	otherwise	otherwise	RB
cord-323756-atnrw9ew	29	25	elicit	elicit	VB
cord-323756-atnrw9ew	29	26	autoimmune	autoimmune	JJ
cord-323756-atnrw9ew	29	27	responses	response	NNS
cord-323756-atnrw9ew	29	28	.	.	.
cord-323756-atnrw9ew	30	1	Despite	despite	IN
cord-323756-atnrw9ew	30	2	this	this	DT
cord-323756-atnrw9ew	30	3	apparent	apparent	JJ
cord-323756-atnrw9ew	30	4	challenge	challenge	NN
cord-323756-atnrw9ew	30	5	,	,	,
cord-323756-atnrw9ew	30	6	efficient	efficient	JJ
cord-323756-atnrw9ew	30	7	detection	detection	NN
cord-323756-atnrw9ew	30	8	of	of	IN
cord-323756-atnrw9ew	30	9	foreign	foreign	JJ
cord-323756-atnrw9ew	30	10	RNA	RNA	NNP
cord-323756-atnrw9ew	30	11	in	in	IN
cord-323756-atnrw9ew	30	12	the	the	DT
cord-323756-atnrw9ew	30	13	cytosol	cytosol	NN
cord-323756-atnrw9ew	30	14	is	be	VBZ
cord-323756-atnrw9ew	30	15	essential	essential	JJ
cord-323756-atnrw9ew	30	16	for	for	IN
cord-323756-atnrw9ew	30	17	innate	innate	JJ
cord-323756-atnrw9ew	30	18	immunity	immunity	NN
cord-323756-atnrw9ew	30	19	.	.	.
cord-323756-atnrw9ew	31	1	During	during	IN
cord-323756-atnrw9ew	31	2	certain	certain	JJ
cord-323756-atnrw9ew	31	3	viral	viral	JJ
cord-323756-atnrw9ew	31	4	infections	infection	NNS
cord-323756-atnrw9ew	31	5	,	,	,
cord-323756-atnrw9ew	31	6	RNA	RNA	NNP
cord-323756-atnrw9ew	31	7	may	may	MD
cord-323756-atnrw9ew	31	8	be	be	VB
cord-323756-atnrw9ew	31	9	the	the	DT
cord-323756-atnrw9ew	31	10	only	only	JJ
cord-323756-atnrw9ew	31	11	microbial	microbial	JJ
cord-323756-atnrw9ew	31	12	PAMP	PAMP	NNP
cord-323756-atnrw9ew	31	13	produced	produce	VBN
cord-323756-atnrw9ew	31	14	throughout	throughout	IN
cord-323756-atnrw9ew	31	15	most	most	JJS
cord-323756-atnrw9ew	31	16	of	of	IN
cord-323756-atnrw9ew	31	17	the	the	DT
cord-323756-atnrw9ew	31	18	replication	replication	NN
cord-323756-atnrw9ew	31	19	cycle	cycle	NN
cord-323756-atnrw9ew	31	20	.	.	.
cord-323756-atnrw9ew	32	1	Additionally	additionally	RB
cord-323756-atnrw9ew	32	2	,	,	,
cord-323756-atnrw9ew	32	3	our	-PRON-	PRP$
cord-323756-atnrw9ew	32	4	laboratory	laboratory	NN
cord-323756-atnrw9ew	32	5	previously	previously	RB
cord-323756-atnrw9ew	32	6	showed	show	VBD
cord-323756-atnrw9ew	32	7	that	that	IN
cord-323756-atnrw9ew	32	8	recognition	recognition	NN
cord-323756-atnrw9ew	32	9	of	of	IN
cord-323756-atnrw9ew	32	10	bacterial	bacterial	JJ
cord-323756-atnrw9ew	32	11	mRNA	mrna	NN
cord-323756-atnrw9ew	32	12	in	in	IN
cord-323756-atnrw9ew	32	13	the	the	DT
cord-323756-atnrw9ew	32	14	cytosol	cytosol	NN
cord-323756-atnrw9ew	32	15	was	be	VBD
cord-323756-atnrw9ew	32	16	critical	critical	JJ
cord-323756-atnrw9ew	32	17	to	to	TO
cord-323756-atnrw9ew	32	18	elicit	elicit	VB
cord-323756-atnrw9ew	32	19	a	a	DT
cord-323756-atnrw9ew	32	20	robust	robust	JJ
cord-323756-atnrw9ew	32	21	innate	innate	JJ
cord-323756-atnrw9ew	32	22	response	response	NN
cord-323756-atnrw9ew	32	23	against	against	IN
cord-323756-atnrw9ew	32	24	bacterial	bacterial	JJ
cord-323756-atnrw9ew	32	25	infection	infection	NN
cord-323756-atnrw9ew	32	26	(	(	-LRB-
cord-323756-atnrw9ew	32	27	7	7	CD
cord-323756-atnrw9ew	32	28	)	)	-RRB-
cord-323756-atnrw9ew	32	29	.	.	.
cord-323756-atnrw9ew	33	1	Finally	finally	RB
cord-323756-atnrw9ew	33	2	,	,	,
cord-323756-atnrw9ew	33	3	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	33	4	sensing	sensing	NN
cord-323756-atnrw9ew	33	5	of	of	IN
cord-323756-atnrw9ew	33	6	pathogen	pathogen	NN
cord-323756-atnrw9ew	33	7	invasion	invasion	NN
cord-323756-atnrw9ew	33	8	by	by	IN
cord-323756-atnrw9ew	33	9	non	non	JJ
cord-323756-atnrw9ew	33	10	-	-	JJ
cord-323756-atnrw9ew	33	11	immune	immune	JJ
cord-323756-atnrw9ew	33	12	infected	infected	JJ
cord-323756-atnrw9ew	33	13	cells	cell	NNS
cord-323756-atnrw9ew	33	14	provides	provide	VBZ
cord-323756-atnrw9ew	33	15	the	the	DT
cord-323756-atnrw9ew	33	16	very	very	RB
cord-323756-atnrw9ew	33	17	first	first	JJ
cord-323756-atnrw9ew	33	18	steps	step	NNS
cord-323756-atnrw9ew	33	19	of	of	IN
cord-323756-atnrw9ew	33	20	innate	innate	JJ
cord-323756-atnrw9ew	33	21	response	response	NN
cord-323756-atnrw9ew	33	22	against	against	IN
cord-323756-atnrw9ew	33	23	infection	infection	NN
cord-323756-atnrw9ew	33	24	,	,	,
cord-323756-atnrw9ew	33	25	before	before	IN
cord-323756-atnrw9ew	33	26	phagocytosis	phagocytosis	NN
cord-323756-atnrw9ew	33	27	-	-	HYPH
cord-323756-atnrw9ew	33	28	competent	competent	JJ
cord-323756-atnrw9ew	33	29	immune	immune	JJ
cord-323756-atnrw9ew	33	30	cells	cell	NNS
cord-323756-atnrw9ew	33	31	are	be	VBP
cord-323756-atnrw9ew	33	32	recruited	recruit	VBN
cord-323756-atnrw9ew	33	33	to	to	IN
cord-323756-atnrw9ew	33	34	the	the	DT
cord-323756-atnrw9ew	33	35	site	site	NN
cord-323756-atnrw9ew	33	36	of	of	IN
cord-323756-atnrw9ew	33	37	infection	infection	NN
cord-323756-atnrw9ew	33	38	.	.	.
cord-323756-atnrw9ew	34	1	In	in	IN
cord-323756-atnrw9ew	34	2	this	this	DT
cord-323756-atnrw9ew	34	3	review	review	NN
cord-323756-atnrw9ew	34	4	,	,	,
cord-323756-atnrw9ew	34	5	we	-PRON-	PRP
cord-323756-atnrw9ew	34	6	summarize	summarize	VBP
cord-323756-atnrw9ew	34	7	the	the	DT
cord-323756-atnrw9ew	34	8	current	current	JJ
cord-323756-atnrw9ew	34	9	understanding	understanding	NN
cord-323756-atnrw9ew	34	10	of	of	IN
cord-323756-atnrw9ew	34	11	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	34	12	RNA	RNA	NNP
cord-323756-atnrw9ew	34	13	sensing	sensing	NN
cord-323756-atnrw9ew	34	14	.	.	.
cord-323756-atnrw9ew	35	1	We	-PRON-	PRP
cord-323756-atnrw9ew	35	2	describe	describe	VBP
cord-323756-atnrw9ew	35	3	instances	instance	NNS
cord-323756-atnrw9ew	35	4	in	in	IN
cord-323756-atnrw9ew	35	5	which	which	WDT
cord-323756-atnrw9ew	35	6	microbial	microbial	JJ
cord-323756-atnrw9ew	35	7	RNAs	rna	NNS
cord-323756-atnrw9ew	35	8	gain	gain	VBP
cord-323756-atnrw9ew	35	9	access	access	NN
cord-323756-atnrw9ew	35	10	to	to	IN
cord-323756-atnrw9ew	35	11	the	the	DT
cord-323756-atnrw9ew	35	12	cytosol	cytosol	NN
cord-323756-atnrw9ew	35	13	,	,	,
cord-323756-atnrw9ew	35	14	the	the	DT
cord-323756-atnrw9ew	35	15	PRRs	prr	NNS
cord-323756-atnrw9ew	35	16	they	-PRON-	PRP
cord-323756-atnrw9ew	35	17	activate	activate	VBP
cord-323756-atnrw9ew	35	18	,	,	,
cord-323756-atnrw9ew	35	19	their	-PRON-	PRP$
cord-323756-atnrw9ew	35	20	corresponding	corresponding	JJ
cord-323756-atnrw9ew	35	21	ligands	ligand	NNS
cord-323756-atnrw9ew	35	22	and	and	CC
cord-323756-atnrw9ew	35	23	strategies	strategy	NNS
cord-323756-atnrw9ew	35	24	developed	develop	VBN
cord-323756-atnrw9ew	35	25	by	by	IN
cord-323756-atnrw9ew	35	26	microorganisms	microorganism	NNS
cord-323756-atnrw9ew	35	27	to	to	TO
cord-323756-atnrw9ew	35	28	conceal	conceal	VB
cord-323756-atnrw9ew	35	29	their	-PRON-	PRP$
cord-323756-atnrw9ew	35	30	RNAs	rna	NNS
cord-323756-atnrw9ew	35	31	.	.	.
cord-323756-atnrw9ew	36	1	RNA	RNA	NNP
cord-323756-atnrw9ew	36	2	entry	entry	NN
cord-323756-atnrw9ew	36	3	into	into	IN
cord-323756-atnrw9ew	36	4	host	host	NN
cord-323756-atnrw9ew	36	5	cells	cell	NNS
cord-323756-atnrw9ew	36	6	generally	generally	RB
cord-323756-atnrw9ew	36	7	takes	take	VBZ
cord-323756-atnrw9ew	36	8	place	place	NN
cord-323756-atnrw9ew	36	9	during	during	IN
cord-323756-atnrw9ew	36	10	the	the	DT
cord-323756-atnrw9ew	36	11	first	first	JJ
cord-323756-atnrw9ew	36	12	steps	step	NNS
cord-323756-atnrw9ew	36	13	of	of	IN
cord-323756-atnrw9ew	36	14	a	a	DT
cord-323756-atnrw9ew	36	15	microbial	microbial	JJ
cord-323756-atnrw9ew	36	16	infection	infection	NN
cord-323756-atnrw9ew	36	17	.	.	.
cord-323756-atnrw9ew	37	1	We	-PRON-	PRP
cord-323756-atnrw9ew	37	2	distinguish	distinguish	VBP
cord-323756-atnrw9ew	37	3	four	four	CD
cord-323756-atnrw9ew	37	4	processes	process	NNS
cord-323756-atnrw9ew	37	5	leading	lead	VBG
cord-323756-atnrw9ew	37	6	to	to	IN
cord-323756-atnrw9ew	37	7	the	the	DT
cord-323756-atnrw9ew	37	8	presence	presence	NN
cord-323756-atnrw9ew	37	9	of	of	IN
cord-323756-atnrw9ew	37	10	microbial	microbial	JJ
cord-323756-atnrw9ew	37	11	RNA	RNA	NNP
cord-323756-atnrw9ew	37	12	in	in	IN
cord-323756-atnrw9ew	37	13	the	the	DT
cord-323756-atnrw9ew	37	14	cytosol	cytosol	NN
cord-323756-atnrw9ew	37	15	of	of	IN
cord-323756-atnrw9ew	37	16	eukaryotic	eukaryotic	JJ
cord-323756-atnrw9ew	37	17	cells	cell	NNS
cord-323756-atnrw9ew	37	18	,	,	,
cord-323756-atnrw9ew	37	19	where	where	WRB
cord-323756-atnrw9ew	37	20	it	-PRON-	PRP
cord-323756-atnrw9ew	37	21	can	can	MD
cord-323756-atnrw9ew	37	22	engage	engage	VB
cord-323756-atnrw9ew	37	23	host	host	NN
cord-323756-atnrw9ew	37	24	PRRs	prr	NNS
cord-323756-atnrw9ew	37	25	(	(	-LRB-
cord-323756-atnrw9ew	37	26	Figure	figure	NN
cord-323756-atnrw9ew	37	27	1	1	CD
cord-323756-atnrw9ew	37	28	)	)	-RRB-
cord-323756-atnrw9ew	37	29	.	.	.
cord-323756-atnrw9ew	38	1	FIGURE	figure	NN
cord-323756-atnrw9ew	38	2	1	1	CD
cord-323756-atnrw9ew	39	1	|	|	NNP
cord-323756-atnrw9ew	39	2	Cytosolic	Cytosolic	NNP
cord-323756-atnrw9ew	39	3	recognition	recognition	NN
cord-323756-atnrw9ew	39	4	of	of	IN
cord-323756-atnrw9ew	39	5	microbial	microbial	JJ
cord-323756-atnrw9ew	39	6	RNA	RNA	NNP
cord-323756-atnrw9ew	39	7	.	.	.
cord-323756-atnrw9ew	40	1	Genomic	Genomic	NNP
cord-323756-atnrw9ew	40	2	RNA	RNA	NNP
cord-323756-atnrw9ew	40	3	from	from	IN
cord-323756-atnrw9ew	40	4	RNA	RNA	NNP
cord-323756-atnrw9ew	40	5	viruses	virus	NNS
cord-323756-atnrw9ew	40	6	access	access	VBP
cord-323756-atnrw9ew	40	7	the	the	DT
cord-323756-atnrw9ew	40	8	cytosol	cytosol	NN
cord-323756-atnrw9ew	40	9	immediately	immediately	RB
cord-323756-atnrw9ew	40	10	after	after	IN
cord-323756-atnrw9ew	40	11	the	the	DT
cord-323756-atnrw9ew	40	12	cell	cell	NN
cord-323756-atnrw9ew	40	13	entry	entry	NN
cord-323756-atnrw9ew	40	14	step	step	NN
cord-323756-atnrw9ew	40	15	of	of	IN
cord-323756-atnrw9ew	40	16	the	the	DT
cord-323756-atnrw9ew	40	17	replication	replication	NN
cord-323756-atnrw9ew	40	18	cycle	cycle	NN
cord-323756-atnrw9ew	40	19	,	,	,
cord-323756-atnrw9ew	40	20	where	where	WRB
cord-323756-atnrw9ew	40	21	it	-PRON-	PRP
cord-323756-atnrw9ew	40	22	may	may	MD
cord-323756-atnrw9ew	40	23	be	be	VB
cord-323756-atnrw9ew	40	24	amplified	amplify	VBN
cord-323756-atnrw9ew	40	25	by	by	IN
cord-323756-atnrw9ew	40	26	viral	viral	JJ
cord-323756-atnrw9ew	40	27	RNA	RNA	NNP
cord-323756-atnrw9ew	40	28	-	-	HYPH
cord-323756-atnrw9ew	40	29	dependent	dependent	JJ
cord-323756-atnrw9ew	40	30	RNA	RNA	NNP
cord-323756-atnrw9ew	40	31	polymerase	polymerase	NN
cord-323756-atnrw9ew	40	32	(	(	-LRB-
cord-323756-atnrw9ew	40	33	RdRp	RdRp	NNP
cord-323756-atnrw9ew	40	34	)	)	-RRB-
cord-323756-atnrw9ew	40	35	.	.	.
cord-323756-atnrw9ew	41	1	Genomic	genomic	JJ
cord-323756-atnrw9ew	41	2	DNA	dna	NN
cord-323756-atnrw9ew	41	3	from	from	IN
cord-323756-atnrw9ew	41	4	DNA	dna	NN
cord-323756-atnrw9ew	41	5	viruses	virus	NNS
cord-323756-atnrw9ew	41	6	is	be	VBZ
cord-323756-atnrw9ew	41	7	transcribed	transcribe	VBN
cord-323756-atnrw9ew	41	8	by	by	IN
cord-323756-atnrw9ew	41	9	viral	viral	JJ
cord-323756-atnrw9ew	41	10	or	or	CC
cord-323756-atnrw9ew	41	11	cellular	cellular	JJ
cord-323756-atnrw9ew	41	12	RNA	rna	NN
cord-323756-atnrw9ew	41	13	polymerase	polymerase	NN
cord-323756-atnrw9ew	41	14	,	,	,
cord-323756-atnrw9ew	41	15	including	include	VBG
cord-323756-atnrw9ew	41	16	the	the	DT
cord-323756-atnrw9ew	41	17	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	41	18	RNA	RNA	NNP
cord-323756-atnrw9ew	41	19	polymerase	polymerase	NN
cord-323756-atnrw9ew	41	20	III	III	NNP
cord-323756-atnrw9ew	41	21	.	.	.
cord-323756-atnrw9ew	42	1	Bacterial	Bacterial	NNP
cord-323756-atnrw9ew	42	2	RNA	RNA	NNP
cord-323756-atnrw9ew	42	3	can	can	MD
cord-323756-atnrw9ew	42	4	access	access	VB
cord-323756-atnrw9ew	42	5	the	the	DT
cord-323756-atnrw9ew	42	6	cytosol	cytosol	NN
cord-323756-atnrw9ew	42	7	through	through	IN
cord-323756-atnrw9ew	42	8	the	the	DT
cord-323756-atnrw9ew	42	9	activity	activity	NN
cord-323756-atnrw9ew	42	10	of	of	IN
cord-323756-atnrw9ew	42	11	auxiliary	auxiliary	JJ
cord-323756-atnrw9ew	42	12	secretion	secretion	NN
cord-323756-atnrw9ew	42	13	systems	system	NNS
cord-323756-atnrw9ew	42	14	or	or	CC
cord-323756-atnrw9ew	42	15	during	during	IN
cord-323756-atnrw9ew	42	16	passive	passive	JJ
cord-323756-atnrw9ew	42	17	leakage	leakage	NN
cord-323756-atnrw9ew	42	18	of	of	IN
cord-323756-atnrw9ew	42	19	phagosomal	phagosomal	NN
cord-323756-atnrw9ew	42	20	products	product	NNS
cord-323756-atnrw9ew	42	21	.	.	.
cord-323756-atnrw9ew	43	1	Once	once	RB
cord-323756-atnrw9ew	43	2	in	in	IN
cord-323756-atnrw9ew	43	3	the	the	DT
cord-323756-atnrw9ew	43	4	cytosol	cytosol	NN
cord-323756-atnrw9ew	43	5	,	,	,
cord-323756-atnrw9ew	43	6	microbial	microbial	JJ
cord-323756-atnrw9ew	43	7	RNA	RNA	NNP
cord-323756-atnrw9ew	43	8	binds	bind	VBZ
cord-323756-atnrw9ew	43	9	different	different	JJ
cord-323756-atnrw9ew	43	10	families	family	NNS
cord-323756-atnrw9ew	43	11	of	of	IN
cord-323756-atnrw9ew	43	12	PRRs	prr	NNS
cord-323756-atnrw9ew	43	13	classified	classify	VBN
cord-323756-atnrw9ew	43	14	as	as	IN
cord-323756-atnrw9ew	43	15	RLRs	rlr	NNS
cord-323756-atnrw9ew	43	16	,	,	,
cord-323756-atnrw9ew	43	17	non	non	JJ
cord-323756-atnrw9ew	43	18	-	-	JJ
cord-323756-atnrw9ew	43	19	RLR	RLR	NNP
cord-323756-atnrw9ew	43	20	helicases	helicase	NNS
cord-323756-atnrw9ew	43	21	,	,	,
cord-323756-atnrw9ew	43	22	and	and	CC
cord-323756-atnrw9ew	43	23	other	other	JJ
cord-323756-atnrw9ew	43	24	receptors	receptor	NNS
cord-323756-atnrw9ew	43	25	.	.	.
cord-323756-atnrw9ew	44	1	Downstream	downstream	JJ
cord-323756-atnrw9ew	44	2	signaling	signal	VBG
cord-323756-atnrw9ew	44	3	pathways	pathway	NNS
cord-323756-atnrw9ew	44	4	include	include	VBP
cord-323756-atnrw9ew	44	5	activation	activation	NN
cord-323756-atnrw9ew	44	6	of	of	IN
cord-323756-atnrw9ew	44	7	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	44	8	,	,	,
cord-323756-atnrw9ew	44	9	TRIF	TRIF	NNP
cord-323756-atnrw9ew	44	10	,	,	,
cord-323756-atnrw9ew	44	11	and	and	CC
cord-323756-atnrw9ew	44	12	the	the	DT
cord-323756-atnrw9ew	44	13	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	44	14	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	44	15	.	.	.
cord-323756-atnrw9ew	45	1	Black	black	JJ
cord-323756-atnrw9ew	45	2	arrows	arrow	NNS
cord-323756-atnrw9ew	45	3	,	,	,
cord-323756-atnrw9ew	45	4	RNA	RNA	NNP
cord-323756-atnrw9ew	45	5	entry	entry	NN
cord-323756-atnrw9ew	45	6	;	;	:
cord-323756-atnrw9ew	45	7	red	red	JJ
cord-323756-atnrw9ew	45	8	arrows	arrow	NNS
cord-323756-atnrw9ew	45	9	,	,	,
cord-323756-atnrw9ew	45	10	signaling	signal	VBG
cord-323756-atnrw9ew	45	11	pathways	pathway	NNS
cord-323756-atnrw9ew	45	12	.	.	.
cord-323756-atnrw9ew	46	1	step	step	NN
cord-323756-atnrw9ew	46	2	of	of	IN
cord-323756-atnrw9ew	46	3	the	the	DT
cord-323756-atnrw9ew	46	4	replication	replication	NN
cord-323756-atnrw9ew	46	5	cycle	cycle	NN
cord-323756-atnrw9ew	46	6	.	.	.
cord-323756-atnrw9ew	47	1	Viruses	virus	NNS
cord-323756-atnrw9ew	47	2	can	can	MD
cord-323756-atnrw9ew	47	3	directly	directly	RB
cord-323756-atnrw9ew	47	4	release	release	VB
cord-323756-atnrw9ew	47	5	their	-PRON-	PRP$
cord-323756-atnrw9ew	47	6	genome	genome	NN
cord-323756-atnrw9ew	47	7	at	at	IN
cord-323756-atnrw9ew	47	8	the	the	DT
cord-323756-atnrw9ew	47	9	plasma	plasma	NN
cord-323756-atnrw9ew	47	10	membrane	membrane	NN
cord-323756-atnrw9ew	47	11	after	after	IN
cord-323756-atnrw9ew	47	12	binding	bind	VBG
cord-323756-atnrw9ew	47	13	to	to	IN
cord-323756-atnrw9ew	47	14	a	a	DT
cord-323756-atnrw9ew	47	15	receptor	receptor	NN
cord-323756-atnrw9ew	47	16	.	.	.
cord-323756-atnrw9ew	48	1	Alternatively	alternatively	RB
cord-323756-atnrw9ew	48	2	,	,	,
cord-323756-atnrw9ew	48	3	they	-PRON-	PRP
cord-323756-atnrw9ew	48	4	can	can	MD
cord-323756-atnrw9ew	48	5	be	be	VB
cord-323756-atnrw9ew	48	6	first	first	RB
cord-323756-atnrw9ew	48	7	internalized	internalize	VBN
cord-323756-atnrw9ew	48	8	through	through	IN
cord-323756-atnrw9ew	48	9	endocytosis	endocytosis	NN
cord-323756-atnrw9ew	48	10	or	or	CC
cord-323756-atnrw9ew	48	11	macropinocytosis	macropinocytosis	NN
cord-323756-atnrw9ew	48	12	.	.	.
cord-323756-atnrw9ew	49	1	Endocytosed	endocytosed	JJ
cord-323756-atnrw9ew	49	2	virus	virus	NN
cord-323756-atnrw9ew	49	3	particles	particle	NNS
cord-323756-atnrw9ew	49	4	will	will	MD
cord-323756-atnrw9ew	49	5	typically	typically	RB
cord-323756-atnrw9ew	49	6	traffic	traffic	VB
cord-323756-atnrw9ew	49	7	through	through	IN
cord-323756-atnrw9ew	49	8	endosomal	endosomal	JJ
cord-323756-atnrw9ew	49	9	vesicles	vesicle	NNS
cord-323756-atnrw9ew	49	10	by	by	IN
cord-323756-atnrw9ew	49	11	actin	actin	NN
cord-323756-atnrw9ew	49	12	-	-	HYPH
cord-323756-atnrw9ew	49	13	dependent	dependent	JJ
cord-323756-atnrw9ew	49	14	and/or	and/or	CC
cord-323756-atnrw9ew	49	15	microtubule	microtubule	NN
cord-323756-atnrw9ew	49	16	-	-	HYPH
cord-323756-atnrw9ew	49	17	dependent	dependent	JJ
cord-323756-atnrw9ew	49	18	transport	transport	NN
cord-323756-atnrw9ew	49	19	(	(	-LRB-
cord-323756-atnrw9ew	49	20	8)	8)	NN
cord-323756-atnrw9ew	49	21	.	.	.
cord-323756-atnrw9ew	50	1	Specific	specific	JJ
cord-323756-atnrw9ew	50	2	environmental	environmental	JJ
cord-323756-atnrw9ew	50	3	triggers	trigger	NNS
cord-323756-atnrw9ew	50	4	like	like	IN
cord-323756-atnrw9ew	50	5	endosomal	endosomal	NNP
cord-323756-atnrw9ew	50	6	pH	pH	NNP
cord-323756-atnrw9ew	50	7	acidification	acidification	NN
cord-323756-atnrw9ew	50	8	induce	induce	VB
cord-323756-atnrw9ew	50	9	either	either	CC
cord-323756-atnrw9ew	50	10	fusion	fusion	NN
cord-323756-atnrw9ew	50	11	of	of	IN
cord-323756-atnrw9ew	50	12	enveloped	envelop	VBN
cord-323756-atnrw9ew	50	13	virus	virus	NN
cord-323756-atnrw9ew	50	14	with	with	IN
cord-323756-atnrw9ew	50	15	the	the	DT
cord-323756-atnrw9ew	50	16	endosome	endosome	NN
cord-323756-atnrw9ew	50	17	,	,	,
cord-323756-atnrw9ew	50	18	or	or	CC
cord-323756-atnrw9ew	50	19	membrane	membrane	NN
cord-323756-atnrw9ew	50	20	penetration	penetration	NN
cord-323756-atnrw9ew	50	21	of	of	IN
cord-323756-atnrw9ew	50	22	viral	viral	JJ
cord-323756-atnrw9ew	50	23	proteins	protein	NNS
cord-323756-atnrw9ew	50	24	,	,	,
cord-323756-atnrw9ew	50	25	allowing	allow	VBG
cord-323756-atnrw9ew	50	26	viral	viral	JJ
cord-323756-atnrw9ew	50	27	genetic	genetic	JJ
cord-323756-atnrw9ew	50	28	material	material	NN
cord-323756-atnrw9ew	50	29	to	to	TO
cord-323756-atnrw9ew	50	30	be	be	VB
cord-323756-atnrw9ew	50	31	released	release	VBN
cord-323756-atnrw9ew	50	32	into	into	IN
cord-323756-atnrw9ew	50	33	the	the	DT
cord-323756-atnrw9ew	50	34	cytoplasm	cytoplasm	NN
cord-323756-atnrw9ew	50	35	(	(	-LRB-
cord-323756-atnrw9ew	50	36	8)	8)	NN
cord-323756-atnrw9ew	50	37	.	.	.
cord-323756-atnrw9ew	51	1	Alternatively	alternatively	RB
cord-323756-atnrw9ew	51	2	,	,	,
cord-323756-atnrw9ew	51	3	viruses	virus	NNS
cord-323756-atnrw9ew	51	4	can	can	MD
cord-323756-atnrw9ew	51	5	spread	spread	VB
cord-323756-atnrw9ew	51	6	by	by	IN
cord-323756-atnrw9ew	51	7	direct	direct	JJ
cord-323756-atnrw9ew	51	8	cell	cell	NN
cord-323756-atnrw9ew	51	9	-	-	HYPH
cord-323756-atnrw9ew	51	10	cell	cell	NN
cord-323756-atnrw9ew	51	11	contact	contact	NN
cord-323756-atnrw9ew	51	12	(	(	-LRB-
cord-323756-atnrw9ew	51	13	9	9	CD
cord-323756-atnrw9ew	51	14	)	)	-RRB-
cord-323756-atnrw9ew	51	15	.	.	.
cord-323756-atnrw9ew	52	1	Cell	cell	NN
cord-323756-atnrw9ew	52	2	-	-	HYPH
cord-323756-atnrw9ew	52	3	to	to	IN
cord-323756-atnrw9ew	52	4	-	-	HYPH
cord-323756-atnrw9ew	52	5	cell	cell	NN
cord-323756-atnrw9ew	52	6	transmission	transmission	NN
cord-323756-atnrw9ew	52	7	of	of	IN
cord-323756-atnrw9ew	52	8	viral	viral	JJ
cord-323756-atnrw9ew	52	9	material	material	NN
cord-323756-atnrw9ew	52	10	can	can	MD
cord-323756-atnrw9ew	52	11	activate	activate	VB
cord-323756-atnrw9ew	52	12	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	52	13	innate	innate	JJ
cord-323756-atnrw9ew	52	14	pathways	pathway	NNS
cord-323756-atnrw9ew	52	15	,	,	,
cord-323756-atnrw9ew	52	16	as	as	IN
cord-323756-atnrw9ew	52	17	exemplified	exemplify	VBN
cord-323756-atnrw9ew	52	18	with	with	IN
cord-323756-atnrw9ew	52	19	hepatitis	hepatitis	NN
cord-323756-atnrw9ew	52	20	C	C	NNP
cord-323756-atnrw9ew	52	21	virus	virus	NN
cord-323756-atnrw9ew	52	22	(	(	-LRB-
cord-323756-atnrw9ew	52	23	10	10	CD
cord-323756-atnrw9ew	52	24	)	)	-RRB-
cord-323756-atnrw9ew	52	25	,	,	,
cord-323756-atnrw9ew	52	26	lymphocytic	lymphocytic	JJ
cord-323756-atnrw9ew	52	27	choriomeningitis	choriomeningitis	NNP
cord-323756-atnrw9ew	52	28	virus	virus	NN
cord-323756-atnrw9ew	52	29	(	(	-LRB-
cord-323756-atnrw9ew	52	30	11	11	CD
cord-323756-atnrw9ew	52	31	)	)	-RRB-
cord-323756-atnrw9ew	52	32	,	,	,
cord-323756-atnrw9ew	52	33	or	or	CC
cord-323756-atnrw9ew	52	34	human	human	JJ
cord-323756-atnrw9ew	52	35	immunodeficiency	immunodeficiency	NN
cord-323756-atnrw9ew	52	36	virus	virus	NN
cord-323756-atnrw9ew	52	37	transmission	transmission	NN
cord-323756-atnrw9ew	52	38	(	(	-LRB-
cord-323756-atnrw9ew	52	39	12	12	CD
cord-323756-atnrw9ew	52	40	)	)	-RRB-
cord-323756-atnrw9ew	52	41	.	.	.
cord-323756-atnrw9ew	53	1	Other	other	JJ
cord-323756-atnrw9ew	53	2	viral	viral	JJ
cord-323756-atnrw9ew	53	3	RNA	RNA	NNP
cord-323756-atnrw9ew	53	4	PAMPs	pamp	NNS
cord-323756-atnrw9ew	53	5	can	can	MD
cord-323756-atnrw9ew	53	6	be	be	VB
cord-323756-atnrw9ew	53	7	produced	produce	VBN
cord-323756-atnrw9ew	53	8	during	during	IN
cord-323756-atnrw9ew	53	9	viral	viral	JJ
cord-323756-atnrw9ew	53	10	replication	replication	NN
cord-323756-atnrw9ew	53	11	.	.	.
cord-323756-atnrw9ew	54	1	David	David	NNP
cord-323756-atnrw9ew	54	2	Baltimore	Baltimore	NNP
cord-323756-atnrw9ew	54	3	has	have	VBZ
cord-323756-atnrw9ew	54	4	defined	define	VBN
cord-323756-atnrw9ew	54	5	a	a	DT
cord-323756-atnrw9ew	54	6	classification	classification	NN
cord-323756-atnrw9ew	54	7	of	of	IN
cord-323756-atnrw9ew	54	8	viruses	virus	NNS
cord-323756-atnrw9ew	54	9	based	base	VBN
cord-323756-atnrw9ew	54	10	on	on	IN
cord-323756-atnrw9ew	54	11	the	the	DT
cord-323756-atnrw9ew	54	12	mechanism	mechanism	NN
cord-323756-atnrw9ew	54	13	of	of	IN
cord-323756-atnrw9ew	54	14	mRNA	mRNA	NNP
cord-323756-atnrw9ew	54	15	production	production	NN
cord-323756-atnrw9ew	54	16	(	(	-LRB-
cord-323756-atnrw9ew	54	17	13	13	CD
cord-323756-atnrw9ew	54	18	)	)	-RRB-
cord-323756-atnrw9ew	54	19	.	.	.
cord-323756-atnrw9ew	55	1	Viruses	virus	NNS
cord-323756-atnrw9ew	55	2	are	be	VBP
cord-323756-atnrw9ew	55	3	clustered	cluster	VBN
cord-323756-atnrw9ew	55	4	in	in	IN
cord-323756-atnrw9ew	55	5	seven	seven	CD
cord-323756-atnrw9ew	55	6	groups	group	NNS
cord-323756-atnrw9ew	55	7	depending	depend	VBG
cord-323756-atnrw9ew	55	8	on	on	IN
cord-323756-atnrw9ew	55	9	their	-PRON-	PRP$
cord-323756-atnrw9ew	55	10	genomes	genome	NNS
cord-323756-atnrw9ew	55	11	(	(	-LRB-
cord-323756-atnrw9ew	55	12	DNA	DNA	NNP
cord-323756-atnrw9ew	55	13	,	,	,
cord-323756-atnrw9ew	55	14	RNA	RNA	NNP
cord-323756-atnrw9ew	55	15	)	)	-RRB-
cord-323756-atnrw9ew	55	16	,	,	,
cord-323756-atnrw9ew	55	17	strandedness	strandedness	NNP
cord-323756-atnrw9ew	55	18	(	(	-LRB-
cord-323756-atnrw9ew	55	19	single	single	JJ
cord-323756-atnrw9ew	55	20	or	or	CC
cord-323756-atnrw9ew	55	21	double	double	JJ
cord-323756-atnrw9ew	55	22	)	)	-RRB-
cord-323756-atnrw9ew	55	23	,	,	,
cord-323756-atnrw9ew	55	24	sense	sense	NN
cord-323756-atnrw9ew	55	25	or	or	CC
cord-323756-atnrw9ew	55	26	antisense	antisense	NN
cord-323756-atnrw9ew	55	27	,	,	,
cord-323756-atnrw9ew	55	28	and	and	CC
cord-323756-atnrw9ew	55	29	method	method	NN
cord-323756-atnrw9ew	55	30	of	of	IN
cord-323756-atnrw9ew	55	31	replication	replication	NN
cord-323756-atnrw9ew	55	32	.	.	.
cord-323756-atnrw9ew	56	1	The	the	DT
cord-323756-atnrw9ew	56	2	type	type	NN
cord-323756-atnrw9ew	56	3	of	of	IN
cord-323756-atnrw9ew	56	4	RNA	rna	NN
cord-323756-atnrw9ew	56	5	ligands	ligand	NNS
cord-323756-atnrw9ew	56	6	produced	produce	VBN
cord-323756-atnrw9ew	56	7	during	during	IN
cord-323756-atnrw9ew	56	8	viral	viral	JJ
cord-323756-atnrw9ew	56	9	replication	replication	NN
cord-323756-atnrw9ew	56	10	will	will	MD
cord-323756-atnrw9ew	56	11	depend	depend	VB
cord-323756-atnrw9ew	56	12	on	on	IN
cord-323756-atnrw9ew	56	13	the	the	DT
cord-323756-atnrw9ew	56	14	type	type	NN
cord-323756-atnrw9ew	56	15	of	of	IN
cord-323756-atnrw9ew	56	16	viral	viral	JJ
cord-323756-atnrw9ew	56	17	genome	genome	NN
cord-323756-atnrw9ew	56	18	and	and	CC
cord-323756-atnrw9ew	56	19	the	the	DT
cord-323756-atnrw9ew	56	20	strategy	strategy	NN
cord-323756-atnrw9ew	56	21	used	use	VBN
cord-323756-atnrw9ew	56	22	to	to	TO
cord-323756-atnrw9ew	56	23	generate	generate	VB
cord-323756-atnrw9ew	56	24	mRNA	mRNA	NNP
cord-323756-atnrw9ew	56	25	.	.	.
cord-323756-atnrw9ew	57	1	RNA	RNA	NNP
cord-323756-atnrw9ew	57	2	ligands	ligand	NNS
cord-323756-atnrw9ew	57	3	can	can	MD
cord-323756-atnrw9ew	57	4	be	be	VB
cord-323756-atnrw9ew	57	5	generated	generate	VBN
cord-323756-atnrw9ew	57	6	by	by	IN
cord-323756-atnrw9ew	57	7	DNA	dna	NN
cord-323756-atnrw9ew	57	8	viruses	virus	NNS
cord-323756-atnrw9ew	57	9	and	and	CC
cord-323756-atnrw9ew	57	10	retroviruses	retrovirus	NNS
cord-323756-atnrw9ew	57	11	via	via	IN
cord-323756-atnrw9ew	57	12	genome	genome	NN
cord-323756-atnrw9ew	57	13	transcription	transcription	NN
cord-323756-atnrw9ew	57	14	,	,	,
cord-323756-atnrw9ew	57	15	or	or	CC
cord-323756-atnrw9ew	57	16	by	by	IN
cord-323756-atnrw9ew	57	17	synthesis	synthesis	NN
cord-323756-atnrw9ew	57	18	of	of	IN
cord-323756-atnrw9ew	57	19	mRNA	mrna	NN
cord-323756-atnrw9ew	57	20	and	and	CC
cord-323756-atnrw9ew	57	21	replication	replication	NN
cord-323756-atnrw9ew	57	22	intermediates	intermediate	NNS
cord-323756-atnrw9ew	57	23	by	by	IN
cord-323756-atnrw9ew	57	24	RNA	rna	NN
cord-323756-atnrw9ew	57	25	-	-	HYPH
cord-323756-atnrw9ew	57	26	dependent	dependent	JJ
cord-323756-atnrw9ew	57	27	RNA	RNA	NNP
cord-323756-atnrw9ew	57	28	polymerases	polymerase	NNS
cord-323756-atnrw9ew	57	29	(	(	-LRB-
cord-323756-atnrw9ew	57	30	RdRps	RdRps	NNP
cord-323756-atnrw9ew	57	31	)	)	-RRB-
cord-323756-atnrw9ew	57	32	of	of	IN
cord-323756-atnrw9ew	57	33	RNA	RNA	NNP
cord-323756-atnrw9ew	57	34	viruses	virus	NNS
cord-323756-atnrw9ew	57	35	(	(	-LRB-
cord-323756-atnrw9ew	57	36	8)	8)	NNP
cord-323756-atnrw9ew	57	37	.	.	.
cord-323756-atnrw9ew	58	1	It	-PRON-	PRP
cord-323756-atnrw9ew	58	2	has	have	VBZ
cord-323756-atnrw9ew	58	3	been	be	VBN
cord-323756-atnrw9ew	58	4	shown	show	VBN
cord-323756-atnrw9ew	58	5	that	that	IN
cord-323756-atnrw9ew	58	6	ligands	ligand	NNS
cord-323756-atnrw9ew	58	7	generated	generate	VBN
cord-323756-atnrw9ew	58	8	in	in	IN
cord-323756-atnrw9ew	58	9	phagolysosomes	phagolysosome	NNS
cord-323756-atnrw9ew	58	10	after	after	IN
cord-323756-atnrw9ew	58	11	phagocytosis	phagocytosis	NN
cord-323756-atnrw9ew	58	12	of	of	IN
cord-323756-atnrw9ew	58	13	bacteria	bacteria	NNS
cord-323756-atnrw9ew	58	14	by	by	IN
cord-323756-atnrw9ew	58	15	immune	immune	JJ
cord-323756-atnrw9ew	58	16	cells	cell	NNS
cord-323756-atnrw9ew	58	17	can	can	MD
cord-323756-atnrw9ew	58	18	engage	engage	VB
cord-323756-atnrw9ew	58	19	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	58	20	innate	innate	JJ
cord-323756-atnrw9ew	58	21	immune	immune	JJ
cord-323756-atnrw9ew	58	22	receptors	receptor	NNS
cord-323756-atnrw9ew	58	23	(	(	-LRB-
cord-323756-atnrw9ew	58	24	14	14	CD
cord-323756-atnrw9ew	58	25	)	)	-RRB-
cord-323756-atnrw9ew	58	26	.	.	.
cord-323756-atnrw9ew	59	1	Similarly	similarly	RB
cord-323756-atnrw9ew	59	2	,	,	,
cord-323756-atnrw9ew	59	3	we	-PRON-	PRP
cord-323756-atnrw9ew	59	4	showed	show	VBD
cord-323756-atnrw9ew	59	5	that	that	IN
cord-323756-atnrw9ew	59	6	RNA	RNA	NNP
cord-323756-atnrw9ew	59	7	from	from	IN
cord-323756-atnrw9ew	59	8	Escherichia	Escherichia	NNP
cord-323756-atnrw9ew	59	9	coli	coli	NNS
cord-323756-atnrw9ew	59	10	could	could	MD
cord-323756-atnrw9ew	59	11	activate	activate	VB
cord-323756-atnrw9ew	59	12	receptors	receptor	NNS
cord-323756-atnrw9ew	59	13	in	in	IN
cord-323756-atnrw9ew	59	14	the	the	DT
cord-323756-atnrw9ew	59	15	cytosol	cytosol	NN
cord-323756-atnrw9ew	59	16	after	after	IN
cord-323756-atnrw9ew	59	17	phagocytosis	phagocytosis	NN
cord-323756-atnrw9ew	59	18	by	by	IN
cord-323756-atnrw9ew	59	19	macrophages	macrophage	NNS
cord-323756-atnrw9ew	59	20	(	(	-LRB-
cord-323756-atnrw9ew	59	21	7	7	CD
cord-323756-atnrw9ew	59	22	)	)	-RRB-
cord-323756-atnrw9ew	59	23	.	.	.
cord-323756-atnrw9ew	60	1	We	-PRON-	PRP
cord-323756-atnrw9ew	60	2	demonstrated	demonstrate	VBD
cord-323756-atnrw9ew	60	3	that	that	IN
cord-323756-atnrw9ew	60	4	phagosomes	phagosomes	NNP
cord-323756-atnrw9ew	60	5	carrying	carry	VBG
cord-323756-atnrw9ew	60	6	E.	E.	NNP
cord-323756-atnrw9ew	60	7	coli	coli	NNS
cord-323756-atnrw9ew	60	8	exhibit	exhibit	NN
cord-323756-atnrw9ew	60	9	intrinsic	intrinsic	JJ
cord-323756-atnrw9ew	60	10	leakiness	leakiness	NN
cord-323756-atnrw9ew	60	11	,	,	,
cord-323756-atnrw9ew	60	12	suggesting	suggest	VBG
cord-323756-atnrw9ew	60	13	a	a	DT
cord-323756-atnrw9ew	60	14	mechanism	mechanism	NN
cord-323756-atnrw9ew	60	15	by	by	IN
cord-323756-atnrw9ew	60	16	which	which	WDT
cord-323756-atnrw9ew	60	17	bacterial	bacterial	JJ
cord-323756-atnrw9ew	60	18	RNA	RNA	NNP
cord-323756-atnrw9ew	60	19	,	,	,
cord-323756-atnrw9ew	60	20	irrespective	irrespective	RB
cord-323756-atnrw9ew	60	21	of	of	IN
cord-323756-atnrw9ew	60	22	the	the	DT
cord-323756-atnrw9ew	60	23	activity	activity	NN
cord-323756-atnrw9ew	60	24	of	of	IN
cord-323756-atnrw9ew	60	25	virulence	virulence	NN
cord-323756-atnrw9ew	60	26	factors	factor	NNS
cord-323756-atnrw9ew	60	27	,	,	,
cord-323756-atnrw9ew	60	28	can	can	MD
cord-323756-atnrw9ew	60	29	gain	gain	VB
cord-323756-atnrw9ew	60	30	access	access	NN
cord-323756-atnrw9ew	60	31	to	to	IN
cord-323756-atnrw9ew	60	32	the	the	DT
cord-323756-atnrw9ew	60	33	cytoplasm	cytoplasm	NN
cord-323756-atnrw9ew	60	34	(	(	-LRB-
cord-323756-atnrw9ew	60	35	7	7	CD
cord-323756-atnrw9ew	60	36	)	)	-RRB-
cord-323756-atnrw9ew	60	37	.	.	.
cord-323756-atnrw9ew	61	1	Alternatively	alternatively	RB
cord-323756-atnrw9ew	61	2	,	,	,
cord-323756-atnrw9ew	61	3	bacteria	bacteria	NNS
cord-323756-atnrw9ew	61	4	express	express	VBP
cord-323756-atnrw9ew	61	5	secretion	secretion	NN
cord-323756-atnrw9ew	61	6	systems	system	NNS
cord-323756-atnrw9ew	61	7	to	to	TO
cord-323756-atnrw9ew	61	8	translocate	translocate	VB
cord-323756-atnrw9ew	61	9	products	product	NNS
cord-323756-atnrw9ew	61	10	outside	outside	RB
cord-323756-atnrw9ew	61	11	of	of	IN
cord-323756-atnrw9ew	61	12	the	the	DT
cord-323756-atnrw9ew	61	13	bacterial	bacterial	JJ
cord-323756-atnrw9ew	61	14	cell	cell	NN
cord-323756-atnrw9ew	61	15	wall	wall	NN
cord-323756-atnrw9ew	61	16	.	.	.
cord-323756-atnrw9ew	62	1	In	in	IN
cord-323756-atnrw9ew	62	2	the	the	DT
cord-323756-atnrw9ew	62	3	case	case	NN
cord-323756-atnrw9ew	62	4	of	of	IN
cord-323756-atnrw9ew	62	5	intracellular	intracellular	JJ
cord-323756-atnrw9ew	62	6	bacteria	bacteria	NNS
cord-323756-atnrw9ew	62	7	,	,	,
cord-323756-atnrw9ew	62	8	auxiliary	auxiliary	JJ
cord-323756-atnrw9ew	62	9	secretion	secretion	NN
cord-323756-atnrw9ew	62	10	systems	system	NNS
cord-323756-atnrw9ew	62	11	like	like	IN
cord-323756-atnrw9ew	62	12	SecA2	SecA2	NNP
cord-323756-atnrw9ew	62	13	in	in	IN
cord-323756-atnrw9ew	62	14	Listeria	Listeria	NNP
cord-323756-atnrw9ew	62	15	monocytogenes	monocytogene	NNS
cord-323756-atnrw9ew	62	16	have	have	VBP
cord-323756-atnrw9ew	62	17	been	be	VBN
cord-323756-atnrw9ew	62	18	shown	show	VBN
cord-323756-atnrw9ew	62	19	to	to	TO
cord-323756-atnrw9ew	62	20	actively	actively	RB
cord-323756-atnrw9ew	62	21	translocate	translocate	VB
cord-323756-atnrw9ew	62	22	Listeria	Listeria	NNP
cord-323756-atnrw9ew	62	23	RNA	RNA	NNP
cord-323756-atnrw9ew	62	24	into	into	IN
cord-323756-atnrw9ew	62	25	the	the	DT
cord-323756-atnrw9ew	62	26	cytoplasm	cytoplasm	NN
cord-323756-atnrw9ew	62	27	,	,	,
cord-323756-atnrw9ew	62	28	resulting	result	VBG
cord-323756-atnrw9ew	62	29	in	in	IN
cord-323756-atnrw9ew	62	30	activation	activation	NN
cord-323756-atnrw9ew	62	31	of	of	IN
cord-323756-atnrw9ew	62	32	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	62	33	sensors	sensor	NNS
cord-323756-atnrw9ew	62	34	(	(	-LRB-
cord-323756-atnrw9ew	62	35	15	15	CD
cord-323756-atnrw9ew	62	36	,	,	,
cord-323756-atnrw9ew	62	37	16	16	CD
cord-323756-atnrw9ew	62	38	)	)	-RRB-
cord-323756-atnrw9ew	62	39	.	.	.
cord-323756-atnrw9ew	63	1	Similarly	similarly	RB
cord-323756-atnrw9ew	63	2	,	,	,
cord-323756-atnrw9ew	63	3	another	another	DT
cord-323756-atnrw9ew	63	4	study	study	NN
cord-323756-atnrw9ew	63	5	proved	prove	VBD
cord-323756-atnrw9ew	63	6	that	that	IN
cord-323756-atnrw9ew	63	7	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	63	8	RNA	RNA	NNP
cord-323756-atnrw9ew	63	9	sensors	sensor	NNS
cord-323756-atnrw9ew	63	10	participate	participate	VBP
cord-323756-atnrw9ew	63	11	in	in	IN
cord-323756-atnrw9ew	63	12	the	the	DT
cord-323756-atnrw9ew	63	13	type	type	NN
cord-323756-atnrw9ew	63	14	1	1	CD
cord-323756-atnrw9ew	63	15	interferon	interferon	NN
cord-323756-atnrw9ew	63	16	(	(	-LRB-
cord-323756-atnrw9ew	63	17	IFN	IFN	NNP
cord-323756-atnrw9ew	63	18	-	-	HYPH
cord-323756-atnrw9ew	63	19	I	I	NNP
cord-323756-atnrw9ew	63	20	)	)	-RRB-
cord-323756-atnrw9ew	63	21	response	response	NN
cord-323756-atnrw9ew	63	22	to	to	IN
cord-323756-atnrw9ew	63	23	Legionella	Legionella	NNP
cord-323756-atnrw9ew	63	24	pneumophila	pneumophila	NN
cord-323756-atnrw9ew	63	25	.	.	.
cord-323756-atnrw9ew	64	1	Although	although	IN
cord-323756-atnrw9ew	64	2	the	the	DT
cord-323756-atnrw9ew	64	3	authors	author	NNS
cord-323756-atnrw9ew	64	4	did	do	VBD
cord-323756-atnrw9ew	64	5	not	not	RB
cord-323756-atnrw9ew	64	6	demonstrate	demonstrate	VB
cord-323756-atnrw9ew	64	7	the	the	DT
cord-323756-atnrw9ew	64	8	translocation	translocation	NN
cord-323756-atnrw9ew	64	9	of	of	IN
cord-323756-atnrw9ew	64	10	Legionella	Legionella	NNP
cord-323756-atnrw9ew	64	11	RNA	RNA	NNP
cord-323756-atnrw9ew	64	12	into	into	IN
cord-323756-atnrw9ew	64	13	the	the	DT
cord-323756-atnrw9ew	64	14	cytosol	cytosol	NN
cord-323756-atnrw9ew	64	15	of	of	IN
cord-323756-atnrw9ew	64	16	infected	infected	JJ
cord-323756-atnrw9ew	64	17	cells	cell	NNS
cord-323756-atnrw9ew	64	18	,	,	,
cord-323756-atnrw9ew	64	19	they	-PRON-	PRP
cord-323756-atnrw9ew	64	20	discuss	discuss	VBP
cord-323756-atnrw9ew	64	21	their	-PRON-	PRP$
cord-323756-atnrw9ew	64	22	data	datum	NNS
cord-323756-atnrw9ew	64	23	through	through	IN
cord-323756-atnrw9ew	64	24	a	a	DT
cord-323756-atnrw9ew	64	25	model	model	NN
cord-323756-atnrw9ew	64	26	where	where	WRB
cord-323756-atnrw9ew	64	27	it	-PRON-	PRP
cord-323756-atnrw9ew	64	28	would	would	MD
cord-323756-atnrw9ew	64	29	be	be	VB
cord-323756-atnrw9ew	64	30	the	the	DT
cord-323756-atnrw9ew	64	31	case	case	NN
cord-323756-atnrw9ew	64	32	(	(	-LRB-
cord-323756-atnrw9ew	64	33	17	17	CD
cord-323756-atnrw9ew	64	34	)	)	-RRB-
cord-323756-atnrw9ew	64	35	.	.	.
cord-323756-atnrw9ew	65	1	Future	future	JJ
cord-323756-atnrw9ew	65	2	studies	study	NNS
cord-323756-atnrw9ew	65	3	looking	look	VBG
cord-323756-atnrw9ew	65	4	for	for	IN
cord-323756-atnrw9ew	65	5	additional	additional	JJ
cord-323756-atnrw9ew	65	6	secreted	secrete	VBN
cord-323756-atnrw9ew	65	7	RNA	RNA	NNP
cord-323756-atnrw9ew	65	8	will	will	MD
cord-323756-atnrw9ew	65	9	likely	likely	RB
cord-323756-atnrw9ew	65	10	provide	provide	VB
cord-323756-atnrw9ew	65	11	additional	additional	JJ
cord-323756-atnrw9ew	65	12	insights	insight	NNS
cord-323756-atnrw9ew	65	13	on	on	IN
cord-323756-atnrw9ew	65	14	their	-PRON-	PRP$
cord-323756-atnrw9ew	65	15	interaction	interaction	NN
cord-323756-atnrw9ew	65	16	with	with	IN
cord-323756-atnrw9ew	65	17	the	the	DT
cord-323756-atnrw9ew	65	18	innate	innate	JJ
cord-323756-atnrw9ew	65	19	immune	immune	JJ
cord-323756-atnrw9ew	65	20	system	system	NN
cord-323756-atnrw9ew	65	21	.	.	.
cord-323756-atnrw9ew	66	1	Two	two	CD
cord-323756-atnrw9ew	66	2	independent	independent	JJ
cord-323756-atnrw9ew	66	3	groups	group	NNS
cord-323756-atnrw9ew	66	4	have	have	VBP
cord-323756-atnrw9ew	66	5	demonstrated	demonstrate	VBN
cord-323756-atnrw9ew	66	6	that	that	IN
cord-323756-atnrw9ew	66	7	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	66	8	dsDNA	dsdna	NN
cord-323756-atnrw9ew	66	9	triggers	trigger	VBZ
cord-323756-atnrw9ew	66	10	IFN	IFN	NNP
cord-323756-atnrw9ew	66	11	-	-	HYPH
cord-323756-atnrw9ew	66	12	I	-PRON-	PRP
cord-323756-atnrw9ew	66	13	production	production	NN
cord-323756-atnrw9ew	66	14	via	via	IN
cord-323756-atnrw9ew	66	15	RNA	RNA	NNP
cord-323756-atnrw9ew	66	16	polymerase	polymerase	NN
cord-323756-atnrw9ew	66	17	III	III	NNP
cord-323756-atnrw9ew	66	18	,	,	,
cord-323756-atnrw9ew	66	19	which	which	WDT
cord-323756-atnrw9ew	66	20	transcribes	transcribe	VBZ
cord-323756-atnrw9ew	66	21	DNA	DNA	NNP
cord-323756-atnrw9ew	66	22	into	into	IN
cord-323756-atnrw9ew	66	23	5'-triphosphate	5'-triphosphate	CD
cord-323756-atnrw9ew	66	24	(	(	-LRB-
cord-323756-atnrw9ew	66	25	5	5	CD
cord-323756-atnrw9ew	66	26	-ppp	-ppp	SYM
cord-323756-atnrw9ew	66	27	)	)	-RRB-
cord-323756-atnrw9ew	66	28	RNA	RNA	NNP
cord-323756-atnrw9ew	66	29	,	,	,
cord-323756-atnrw9ew	66	30	subsequently	subsequently	RB
cord-323756-atnrw9ew	66	31	recognized	recognize	VBN
cord-323756-atnrw9ew	66	32	by	by	IN
cord-323756-atnrw9ew	66	33	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	66	34	RNA	RNA	NNP
cord-323756-atnrw9ew	66	35	receptors	receptor	NNS
cord-323756-atnrw9ew	66	36	(	(	-LRB-
cord-323756-atnrw9ew	66	37	18	18	CD
cord-323756-atnrw9ew	66	38	,	,	,
cord-323756-atnrw9ew	66	39	19	19	CD
cord-323756-atnrw9ew	66	40	)	)	-RRB-
cord-323756-atnrw9ew	66	41	.	.	.
cord-323756-atnrw9ew	67	1	This	this	DT
cord-323756-atnrw9ew	67	2	pathway	pathway	NN
cord-323756-atnrw9ew	67	3	has	have	VBZ
cord-323756-atnrw9ew	67	4	been	be	VBN
cord-323756-atnrw9ew	67	5	involved	involve	VBN
cord-323756-atnrw9ew	67	6	in	in	IN
cord-323756-atnrw9ew	67	7	the	the	DT
cord-323756-atnrw9ew	67	8	sensing	sensing	NN
cord-323756-atnrw9ew	67	9	of	of	IN
cord-323756-atnrw9ew	67	10	DNA	dna	NN
cord-323756-atnrw9ew	67	11	viruses	virus	NNS
cord-323756-atnrw9ew	67	12	,	,	,
cord-323756-atnrw9ew	67	13	like	like	IN
cord-323756-atnrw9ew	67	14	Epstein	Epstein	NNP
cord-323756-atnrw9ew	67	15	-	-	HYPH
cord-323756-atnrw9ew	67	16	Barr	Barr	NNP
cord-323756-atnrw9ew	67	17	virus	virus	NN
cord-323756-atnrw9ew	67	18	,	,	,
cord-323756-atnrw9ew	67	19	or	or	CC
cord-323756-atnrw9ew	67	20	intracellular	intracellular	JJ
cord-323756-atnrw9ew	67	21	bacteria	bacteria	NNS
cord-323756-atnrw9ew	67	22	,	,	,
cord-323756-atnrw9ew	67	23	like	like	IN
cord-323756-atnrw9ew	67	24	L.	L.	NNP
cord-323756-atnrw9ew	67	25	pneumophila	pneumophila	NN
cord-323756-atnrw9ew	67	26	(	(	-LRB-
cord-323756-atnrw9ew	67	27	18	18	CD
cord-323756-atnrw9ew	67	28	,	,	,
cord-323756-atnrw9ew	67	29	19	19	CD
cord-323756-atnrw9ew	67	30	)	)	-RRB-
cord-323756-atnrw9ew	67	31	.	.	.
cord-323756-atnrw9ew	68	1	Although	although	IN
cord-323756-atnrw9ew	68	2	the	the	DT
cord-323756-atnrw9ew	68	3	RNA	RNA	NNP
cord-323756-atnrw9ew	68	4	intermediate	intermediate	NN
cord-323756-atnrw9ew	68	5	produced	produce	VBN
cord-323756-atnrw9ew	68	6	is	be	VBZ
cord-323756-atnrw9ew	68	7	not	not	RB
cord-323756-atnrw9ew	68	8	sensu	sensu	NNP
cord-323756-atnrw9ew	68	9	stricto	stricto	NNP
cord-323756-atnrw9ew	68	10	microbial	microbial	NN
cord-323756-atnrw9ew	68	11	,	,	,
cord-323756-atnrw9ew	68	12	its	-PRON-	PRP$
cord-323756-atnrw9ew	68	13	generation	generation	NN
cord-323756-atnrw9ew	68	14	is	be	VBZ
cord-323756-atnrw9ew	68	15	due	due	JJ
cord-323756-atnrw9ew	68	16	to	to	IN
cord-323756-atnrw9ew	68	17	the	the	DT
cord-323756-atnrw9ew	68	18	activity	activity	NN
cord-323756-atnrw9ew	68	19	of	of	IN
cord-323756-atnrw9ew	68	20	a	a	DT
cord-323756-atnrw9ew	68	21	microbial	microbial	JJ
cord-323756-atnrw9ew	68	22	invader	invader	NN
cord-323756-atnrw9ew	68	23	.	.	.
cord-323756-atnrw9ew	69	1	The	the	DT
cord-323756-atnrw9ew	69	2	best	well	RBS
cord-323756-atnrw9ew	69	3	-	-	HYPH
cord-323756-atnrw9ew	69	4	studied	study	VBN
cord-323756-atnrw9ew	69	5	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	69	6	RNA	RNA	NNP
cord-323756-atnrw9ew	69	7	sensors	sensor	NNS
cord-323756-atnrw9ew	69	8	are	be	VBP
cord-323756-atnrw9ew	69	9	the	the	DT
cord-323756-atnrw9ew	69	10	three	three	CD
cord-323756-atnrw9ew	69	11	members	member	NNS
cord-323756-atnrw9ew	69	12	of	of	IN
cord-323756-atnrw9ew	69	13	RIG	rig	NN
cord-323756-atnrw9ew	69	14	-	-	HYPH
cord-323756-atnrw9ew	69	15	I	i	NN
cord-323756-atnrw9ew	69	16	-	-	HYPH
cord-323756-atnrw9ew	69	17	like	like	JJ
cord-323756-atnrw9ew	69	18	Receptors	receptor	NNS
cord-323756-atnrw9ew	69	19	(	(	-LRB-
cord-323756-atnrw9ew	69	20	RLRs	RLRs	NNP
cord-323756-atnrw9ew	69	21	)	)	-RRB-
cord-323756-atnrw9ew	69	22	,	,	,
cord-323756-atnrw9ew	69	23	a	a	DT
cord-323756-atnrw9ew	69	24	subfamily	subfamily	NN
cord-323756-atnrw9ew	69	25	of	of	IN
cord-323756-atnrw9ew	69	26	the	the	DT
cord-323756-atnrw9ew	69	27	DExD	DExD	NNS
cord-323756-atnrw9ew	69	28	/	/	SYM
cord-323756-atnrw9ew	69	29	Hbox	Hbox	NNP
cord-323756-atnrw9ew	69	30	family	family	NN
cord-323756-atnrw9ew	69	31	of	of	IN
cord-323756-atnrw9ew	69	32	helicases	helicase	NNS
cord-323756-atnrw9ew	69	33	.	.	.
cord-323756-atnrw9ew	70	1	They	-PRON-	PRP
cord-323756-atnrw9ew	70	2	consist	consist	VBP
cord-323756-atnrw9ew	70	3	of	of	IN
cord-323756-atnrw9ew	70	4	retinoic	retinoic	JJ
cord-323756-atnrw9ew	70	5	acid	acid	NN
cord-323756-atnrw9ew	70	6	-	-	HYPH
cord-323756-atnrw9ew	70	7	inducible	inducible	JJ
cord-323756-atnrw9ew	70	8	gene	gene	NN
cord-323756-atnrw9ew	70	9	I	i	NN
cord-323756-atnrw9ew	70	10	(	(	-LRB-
cord-323756-atnrw9ew	70	11	RIG	rig	NN
cord-323756-atnrw9ew	70	12	-	-	:
cord-323756-atnrw9ew	70	13	I	I	NNP
cord-323756-atnrw9ew	70	14	)	)	-RRB-
cord-323756-atnrw9ew	70	15	,	,	,
cord-323756-atnrw9ew	70	16	melanoma	melanoma	NN
cord-323756-atnrw9ew	70	17	differentiation	differentiation	NN
cord-323756-atnrw9ew	70	18	factor	factor	NN
cord-323756-atnrw9ew	70	19	5	5	CD
cord-323756-atnrw9ew	70	20	(	(	-LRB-
cord-323756-atnrw9ew	70	21	MDA5	MDA5	NNP
cord-323756-atnrw9ew	70	22	)	)	-RRB-
cord-323756-atnrw9ew	70	23	,	,	,
cord-323756-atnrw9ew	70	24	and	and	CC
cord-323756-atnrw9ew	70	25	laboratory	laboratory	NN
cord-323756-atnrw9ew	70	26	of	of	IN
cord-323756-atnrw9ew	70	27	genetics	genetic	NNS
cord-323756-atnrw9ew	70	28	and	and	CC
cord-323756-atnrw9ew	70	29	physiology	physiology	NN
cord-323756-atnrw9ew	70	30	2	2	CD
cord-323756-atnrw9ew	70	31	(	(	-LRB-
cord-323756-atnrw9ew	70	32	LGP2	LGP2	NNP
cord-323756-atnrw9ew	70	33	)	)	-RRB-
cord-323756-atnrw9ew	70	34	.	.	.
cord-323756-atnrw9ew	71	1	They	-PRON-	PRP
cord-323756-atnrw9ew	71	2	share	share	VBP
cord-323756-atnrw9ew	71	3	a	a	DT
cord-323756-atnrw9ew	71	4	similar	similar	JJ
cord-323756-atnrw9ew	71	5	organization	organization	NN
cord-323756-atnrw9ew	71	6	with	with	IN
cord-323756-atnrw9ew	71	7	three	three	CD
cord-323756-atnrw9ew	71	8	distinct	distinct	JJ
cord-323756-atnrw9ew	71	9	domains	domain	NNS
cord-323756-atnrw9ew	71	10	:	:	:
cord-323756-atnrw9ew	71	11	(	(	-LRB-
cord-323756-atnrw9ew	71	12	i	i	NN
cord-323756-atnrw9ew	71	13	)	)	-RRB-
cord-323756-atnrw9ew	71	14	a	a	DT
cord-323756-atnrw9ew	71	15	C	c	NN
cord-323756-atnrw9ew	71	16	-	-	HYPH
cord-323756-atnrw9ew	71	17	terminal	terminal	NN
cord-323756-atnrw9ew	71	18	repressor	repressor	NN
cord-323756-atnrw9ew	71	19	domain	domain	NN
cord-323756-atnrw9ew	71	20	(	(	-LRB-
cord-323756-atnrw9ew	71	21	RD	RD	NNP
cord-323756-atnrw9ew	71	22	)	)	-RRB-
cord-323756-atnrw9ew	71	23	embedded	embed	VBN
cord-323756-atnrw9ew	71	24	within	within	IN
cord-323756-atnrw9ew	71	25	the	the	DT
cord-323756-atnrw9ew	71	26	C	c	NN
cord-323756-atnrw9ew	71	27	-	-	HYPH
cord-323756-atnrw9ew	71	28	terminal	terminal	NN
cord-323756-atnrw9ew	71	29	domain	domain	NN
cord-323756-atnrw9ew	71	30	(	(	-LRB-
cord-323756-atnrw9ew	71	31	CTD	CTD	NNP
cord-323756-atnrw9ew	71	32	)	)	-RRB-
cord-323756-atnrw9ew	71	33	;	;	:
cord-323756-atnrw9ew	71	34	(	(	-LRB-
cord-323756-atnrw9ew	71	35	ii	ii	NN
cord-323756-atnrw9ew	71	36	)	)	-RRB-
cord-323756-atnrw9ew	71	37	a	a	DT
cord-323756-atnrw9ew	71	38	central	central	JJ
cord-323756-atnrw9ew	71	39	ATPase	ATPase	NNP
cord-323756-atnrw9ew	71	40	containing	containing	NN
cord-323756-atnrw9ew	71	41	DExD	DExD	NNP
cord-323756-atnrw9ew	71	42	/	/	SYM
cord-323756-atnrw9ew	71	43	H	h	NN
cord-323756-atnrw9ew	71	44	-	-	HYPH
cord-323756-atnrw9ew	71	45	box	box	NN
cord-323756-atnrw9ew	71	46	helicase	helicase	NN
cord-323756-atnrw9ew	71	47	domain	domain	NN
cord-323756-atnrw9ew	71	48	able	able	JJ
cord-323756-atnrw9ew	71	49	to	to	TO
cord-323756-atnrw9ew	71	50	bind	bind	VB
cord-323756-atnrw9ew	71	51	RNA	RNA	NNP
cord-323756-atnrw9ew	71	52	;	;	:
cord-323756-atnrw9ew	71	53	and	and	CC
cord-323756-atnrw9ew	71	54	(	(	-LRB-
cord-323756-atnrw9ew	71	55	iii	iii	NN
cord-323756-atnrw9ew	71	56	)	)	-RRB-
cord-323756-atnrw9ew	71	57	a	a	DT
cord-323756-atnrw9ew	71	58	N	n	CD
cord-323756-atnrw9ew	71	59	-	-	HYPH
cord-323756-atnrw9ew	71	60	terminal	terminal	JJ
cord-323756-atnrw9ew	71	61	tandem	tandem	NN
cord-323756-atnrw9ew	71	62	CARD	card	NN
cord-323756-atnrw9ew	71	63	domain	domain	NN
cord-323756-atnrw9ew	71	64	that	that	WDT
cord-323756-atnrw9ew	71	65	mediates	mediate	VBZ
cord-323756-atnrw9ew	71	66	downstream	downstream	RB
cord-323756-atnrw9ew	71	67	signaling	signaling	NN
cord-323756-atnrw9ew	71	68	,	,	,
cord-323756-atnrw9ew	71	69	and	and	CC
cord-323756-atnrw9ew	71	70	which	which	WDT
cord-323756-atnrw9ew	71	71	is	be	VBZ
cord-323756-atnrw9ew	71	72	present	present	JJ
cord-323756-atnrw9ew	71	73	in	in	IN
cord-323756-atnrw9ew	71	74	RIG	rig	NN
cord-323756-atnrw9ew	71	75	-	-	:
cord-323756-atnrw9ew	71	76	I	I	NNP
cord-323756-atnrw9ew	71	77	and	and	CC
cord-323756-atnrw9ew	71	78	MDA5	MDA5	NNP
cord-323756-atnrw9ew	71	79	but	but	CC
cord-323756-atnrw9ew	71	80	absent	absent	JJ
cord-323756-atnrw9ew	71	81	in	in	IN
cord-323756-atnrw9ew	71	82	LGP2	LGP2	NNP
cord-323756-atnrw9ew	71	83	.	.	.
cord-323756-atnrw9ew	72	1	Upon	upon	IN
cord-323756-atnrw9ew	72	2	activation	activation	NN
cord-323756-atnrw9ew	72	3	by	by	IN
cord-323756-atnrw9ew	72	4	RNA	RNA	NNP
cord-323756-atnrw9ew	72	5	ligands	ligand	NNS
cord-323756-atnrw9ew	72	6	,	,	,
cord-323756-atnrw9ew	72	7	RIG	rig	NN
cord-323756-atnrw9ew	72	8	-	-	:
cord-323756-atnrw9ew	72	9	I	I	NNP
cord-323756-atnrw9ew	72	10	and	and	CC
cord-323756-atnrw9ew	72	11	MDA5	MDA5	NNP
cord-323756-atnrw9ew	72	12	are	be	VBP
cord-323756-atnrw9ew	72	13	subsequently	subsequently	RB
cord-323756-atnrw9ew	72	14	recruited	recruit	VBN
cord-323756-atnrw9ew	72	15	to	to	IN
cord-323756-atnrw9ew	72	16	the	the	DT
cord-323756-atnrw9ew	72	17	adaptor	adaptor	NN
cord-323756-atnrw9ew	72	18	protein	protein	NN
cord-323756-atnrw9ew	72	19	Mitochondrial	Mitochondrial	NNP
cord-323756-atnrw9ew	72	20	Antiviral	Antiviral	NNP
cord-323756-atnrw9ew	72	21	Signaling	Signaling	NNP
cord-323756-atnrw9ew	72	22	(	(	-LRB-
cord-323756-atnrw9ew	72	23	MAVS	MAVS	NNP
cord-323756-atnrw9ew	72	24	)	)	-RRB-
cord-323756-atnrw9ew	72	25	via	via	IN
cord-323756-atnrw9ew	72	26	a	a	DT
cord-323756-atnrw9ew	72	27	CARD	card	NN
cord-323756-atnrw9ew	72	28	-	-	HYPH
cord-323756-atnrw9ew	72	29	CARD	card	NN
cord-323756-atnrw9ew	72	30	interaction	interaction	NN
cord-323756-atnrw9ew	72	31	and	and	CC
cord-323756-atnrw9ew	72	32	lead	lead	NN
cord-323756-atnrw9ew	72	33	to	to	IN
cord-323756-atnrw9ew	72	34	activation	activation	NN
cord-323756-atnrw9ew	72	35	of	of	IN
cord-323756-atnrw9ew	72	36	NF	nf	NN
cord-323756-atnrw9ew	72	37	-	-	HYPH
cord-323756-atnrw9ew	72	38	κB	κB	NNP
cord-323756-atnrw9ew	72	39	and	and	CC
cord-323756-atnrw9ew	72	40	IRFs	IRFs	NNP
cord-323756-atnrw9ew	72	41	(	(	-LRB-
cord-323756-atnrw9ew	72	42	20	20	CD
cord-323756-atnrw9ew	72	43	)	)	-RRB-
cord-323756-atnrw9ew	72	44	(	(	-LRB-
cord-323756-atnrw9ew	72	45	21	21	CD
cord-323756-atnrw9ew	72	46	)	)	-RRB-
cord-323756-atnrw9ew	72	47	(	(	-LRB-
cord-323756-atnrw9ew	72	48	22	22	CD
cord-323756-atnrw9ew	72	49	)	)	-RRB-
cord-323756-atnrw9ew	72	50	(	(	-LRB-
cord-323756-atnrw9ew	72	51	23	23	CD
cord-323756-atnrw9ew	72	52	)	)	-RRB-
cord-323756-atnrw9ew	72	53	.	.	.
cord-323756-atnrw9ew	73	1	In	in	IN
cord-323756-atnrw9ew	73	2	contrast	contrast	NN
cord-323756-atnrw9ew	73	3	to	to	IN
cord-323756-atnrw9ew	73	4	TLR	TLR	NNP
cord-323756-atnrw9ew	73	5	expression	expression	NN
cord-323756-atnrw9ew	73	6	that	that	WDT
cord-323756-atnrw9ew	73	7	is	be	VBZ
cord-323756-atnrw9ew	73	8	predominantly	predominantly	RB
cord-323756-atnrw9ew	73	9	expressed	express	VBN
cord-323756-atnrw9ew	73	10	in	in	IN
cord-323756-atnrw9ew	73	11	specialized	specialized	JJ
cord-323756-atnrw9ew	73	12	immune	immune	JJ
cord-323756-atnrw9ew	73	13	cells	cell	NNS
cord-323756-atnrw9ew	73	14	such	such	JJ
cord-323756-atnrw9ew	73	15	as	as	IN
cord-323756-atnrw9ew	73	16	macrophages	macrophage	NNS
cord-323756-atnrw9ew	73	17	and	and	CC
cord-323756-atnrw9ew	73	18	dendritic	dendritic	JJ
cord-323756-atnrw9ew	73	19	cells	cell	NNS
cord-323756-atnrw9ew	73	20	(	(	-LRB-
cord-323756-atnrw9ew	73	21	DCs	DCs	NNP
cord-323756-atnrw9ew	73	22	)	)	-RRB-
cord-323756-atnrw9ew	73	23	,	,	,
cord-323756-atnrw9ew	73	24	RLRs	rlr	NNS
cord-323756-atnrw9ew	73	25	are	be	VBP
cord-323756-atnrw9ew	73	26	found	find	VBN
cord-323756-atnrw9ew	73	27	in	in	IN
cord-323756-atnrw9ew	73	28	the	the	DT
cord-323756-atnrw9ew	73	29	cytosol	cytosol	NN
cord-323756-atnrw9ew	73	30	of	of	IN
cord-323756-atnrw9ew	73	31	most	most	JJS
cord-323756-atnrw9ew	73	32	cell	cell	NN
cord-323756-atnrw9ew	73	33	types	type	NNS
cord-323756-atnrw9ew	73	34	and	and	CC
cord-323756-atnrw9ew	73	35	are	be	VBP
cord-323756-atnrw9ew	73	36	strongly	strongly	RB
cord-323756-atnrw9ew	73	37	induced	induce	VBN
cord-323756-atnrw9ew	73	38	in	in	IN
cord-323756-atnrw9ew	73	39	response	response	NN
cord-323756-atnrw9ew	73	40	to	to	IN
cord-323756-atnrw9ew	73	41	IFN	IFN	NNP
cord-323756-atnrw9ew	73	42	-	-	HYPH
cord-323756-atnrw9ew	73	43	I	I	NNP
cord-323756-atnrw9ew	73	44	(	(	-LRB-
cord-323756-atnrw9ew	73	45	24	24	CD
cord-323756-atnrw9ew	73	46	,	,	,
cord-323756-atnrw9ew	73	47	25	25	CD
cord-323756-atnrw9ew	73	48	)	)	-RRB-
cord-323756-atnrw9ew	73	49	.	.	.
cord-323756-atnrw9ew	74	1	The	the	DT
cord-323756-atnrw9ew	74	2	RIG	rig	NN
cord-323756-atnrw9ew	74	3	-	-	:
cord-323756-atnrw9ew	74	4	I	i	NN
cord-323756-atnrw9ew	74	5	ligand	ligand	NN
cord-323756-atnrw9ew	74	6	has	have	VBZ
cord-323756-atnrw9ew	74	7	been	be	VBN
cord-323756-atnrw9ew	74	8	characterized	characterize	VBN
cord-323756-atnrw9ew	74	9	as	as	IN
cord-323756-atnrw9ew	74	10	an	an	DT
cord-323756-atnrw9ew	74	11	RNA	RNA	NNP
cord-323756-atnrw9ew	74	12	molecule	molecule	NN
cord-323756-atnrw9ew	74	13	with	with	IN
cord-323756-atnrw9ew	74	14	two	two	CD
cord-323756-atnrw9ew	74	15	distinct	distinct	JJ
cord-323756-atnrw9ew	74	16	features	feature	NNS
cord-323756-atnrw9ew	74	17	:	:	:
cord-323756-atnrw9ew	75	1	(	(	-LRB-
cord-323756-atnrw9ew	75	2	i	i	NN
cord-323756-atnrw9ew	75	3	)	)	-RRB-
cord-323756-atnrw9ew	75	4	a	a	DT
cord-323756-atnrw9ew	75	5	5	5	CD
cord-323756-atnrw9ew	75	6	-ppp	-ppp	:
cord-323756-atnrw9ew	75	7	moiety	moiety	NN
cord-323756-atnrw9ew	75	8	(	(	-LRB-
cord-323756-atnrw9ew	75	9	26	26	CD
cord-323756-atnrw9ew	75	10	,	,	,
cord-323756-atnrw9ew	75	11	27	27	CD
cord-323756-atnrw9ew	75	12	)	)	-RRB-
cord-323756-atnrw9ew	75	13	and	and	CC
cord-323756-atnrw9ew	75	14	(	(	-LRB-
cord-323756-atnrw9ew	75	15	ii	ii	NNP
cord-323756-atnrw9ew	75	16	)	)	-RRB-
cord-323756-atnrw9ew	75	17	bluntend	bluntend	NNP
cord-323756-atnrw9ew	75	18	base	base	NNP
cord-323756-atnrw9ew	75	19	pair	pair	NN
cord-323756-atnrw9ew	75	20	at	at	IN
cord-323756-atnrw9ew	75	21	the	the	DT
cord-323756-atnrw9ew	75	22	5'-end	5'-end	CD
cord-323756-atnrw9ew	75	23	(	(	-LRB-
cord-323756-atnrw9ew	75	24	28	28	CD
cord-323756-atnrw9ew	75	25	,	,	,
cord-323756-atnrw9ew	75	26	29	29	CD
cord-323756-atnrw9ew	75	27	)	)	-RRB-
cord-323756-atnrw9ew	75	28	.	.	.
cord-323756-atnrw9ew	76	1	Blunt	blunt	JJ
cord-323756-atnrw9ew	76	2	-	-	HYPH
cord-323756-atnrw9ew	76	3	end	end	NN
cord-323756-atnrw9ew	76	4	base	base	NN
cord-323756-atnrw9ew	76	5	pairs	pair	NNS
cord-323756-atnrw9ew	76	6	can	can	MD
cord-323756-atnrw9ew	76	7	be	be	VB
cord-323756-atnrw9ew	76	8	found	find	VBN
cord-323756-atnrw9ew	76	9	in	in	IN
cord-323756-atnrw9ew	76	10	double	double	RB
cord-323756-atnrw9ew	76	11	-	-	HYPH
cord-323756-atnrw9ew	76	12	stranded	strand	VBN
cord-323756-atnrw9ew	76	13	RNA	RNA	NNP
cord-323756-atnrw9ew	76	14	(	(	-LRB-
cord-323756-atnrw9ew	76	15	dsRNA	dsrna	NN
cord-323756-atnrw9ew	76	16	)	)	-RRB-
cord-323756-atnrw9ew	76	17	and	and	CC
cord-323756-atnrw9ew	76	18	secondary	secondary	JJ
cord-323756-atnrw9ew	76	19	RNA	RNA	NNP
cord-323756-atnrw9ew	76	20	structures	structure	NNS
cord-323756-atnrw9ew	76	21	such	such	JJ
cord-323756-atnrw9ew	76	22	as	as	IN
cord-323756-atnrw9ew	76	23	hairpin	hairpin	NN
cord-323756-atnrw9ew	76	24	or	or	CC
cord-323756-atnrw9ew	76	25	panhandle	panhandle	NN
cord-323756-atnrw9ew	76	26	conformations	conformation	NNS
cord-323756-atnrw9ew	76	27	(	(	-LRB-
cord-323756-atnrw9ew	76	28	28	28	CD
cord-323756-atnrw9ew	76	29	,	,	,
cord-323756-atnrw9ew	76	30	29	29	CD
cord-323756-atnrw9ew	76	31	)	)	-RRB-
cord-323756-atnrw9ew	76	32	.	.	.
cord-323756-atnrw9ew	77	1	Recent	recent	JJ
cord-323756-atnrw9ew	77	2	structural	structural	JJ
cord-323756-atnrw9ew	77	3	studies	study	NNS
cord-323756-atnrw9ew	77	4	have	have	VBP
cord-323756-atnrw9ew	77	5	contributed	contribute	VBN
cord-323756-atnrw9ew	77	6	toward	toward	IN
cord-323756-atnrw9ew	77	7	a	a	DT
cord-323756-atnrw9ew	77	8	better	well	JJR
cord-323756-atnrw9ew	77	9	understanding	understanding	NN
cord-323756-atnrw9ew	77	10	of	of	IN
cord-323756-atnrw9ew	77	11	ligand	ligand	NN
cord-323756-atnrw9ew	77	12	binding	binding	NN
cord-323756-atnrw9ew	77	13	and	and	CC
cord-323756-atnrw9ew	77	14	activation	activation	NN
cord-323756-atnrw9ew	77	15	of	of	IN
cord-323756-atnrw9ew	77	16	RIG	rig	NN
cord-323756-atnrw9ew	77	17	-	-	HYPH
cord-323756-atnrw9ew	77	18	I.	I.	NNP
cord-323756-atnrw9ew	77	19	Specificity	Specificity	NNP
cord-323756-atnrw9ew	77	20	of	of	IN
cord-323756-atnrw9ew	77	21	5	5	CD
cord-323756-atnrw9ew	77	22	-ppp	-ppp	:
cord-323756-atnrw9ew	77	23	binding	binding	NN
cord-323756-atnrw9ew	77	24	is	be	VBZ
cord-323756-atnrw9ew	77	25	conferred	confer	VBN
cord-323756-atnrw9ew	77	26	by	by	IN
cord-323756-atnrw9ew	77	27	the	the	DT
cord-323756-atnrw9ew	77	28	CTD	CTD	NNP
cord-323756-atnrw9ew	77	29	,	,	,
cord-323756-atnrw9ew	77	30	and	and	CC
cord-323756-atnrw9ew	77	31	the	the	DT
cord-323756-atnrw9ew	77	32	helicase	helicase	NN
cord-323756-atnrw9ew	77	33	domain	domain	NN
cord-323756-atnrw9ew	77	34	binds	bind	VBZ
cord-323756-atnrw9ew	77	35	the	the	DT
cord-323756-atnrw9ew	77	36	double	double	RB
cord-323756-atnrw9ew	77	37	-	-	HYPH
cord-323756-atnrw9ew	77	38	stranded	stranded	JJ
cord-323756-atnrw9ew	77	39	part	part	NN
cord-323756-atnrw9ew	77	40	of	of	IN
cord-323756-atnrw9ew	77	41	the	the	DT
cord-323756-atnrw9ew	77	42	RNA	RNA	NNP
cord-323756-atnrw9ew	77	43	.	.	.
cord-323756-atnrw9ew	78	1	RIG	rig	NN
cord-323756-atnrw9ew	78	2	-	-	:
cord-323756-atnrw9ew	78	3	I	-PRON-	PRP
cord-323756-atnrw9ew	78	4	is	be	VBZ
cord-323756-atnrw9ew	78	5	normally	normally	RB
cord-323756-atnrw9ew	78	6	held	hold	VBN
cord-323756-atnrw9ew	78	7	in	in	IN
cord-323756-atnrw9ew	78	8	an	an	DT
cord-323756-atnrw9ew	78	9	auto	auto	NN
cord-323756-atnrw9ew	78	10	-	-	HYPH
cord-323756-atnrw9ew	78	11	repressed	repress	VBN
cord-323756-atnrw9ew	78	12	conformation	conformation	NN
cord-323756-atnrw9ew	78	13	,	,	,
cord-323756-atnrw9ew	78	14	and	and	CC
cord-323756-atnrw9ew	78	15	ligand	ligand	NN
cord-323756-atnrw9ew	78	16	binding	binding	NN
cord-323756-atnrw9ew	78	17	results	result	NNS
cord-323756-atnrw9ew	78	18	in	in	IN
cord-323756-atnrw9ew	78	19	a	a	DT
cord-323756-atnrw9ew	78	20	conformational	conformational	JJ
cord-323756-atnrw9ew	78	21	change	change	NN
cord-323756-atnrw9ew	78	22	,	,	,
cord-323756-atnrw9ew	78	23	releasing	release	VBG
cord-323756-atnrw9ew	78	24	the	the	DT
cord-323756-atnrw9ew	78	25	CARD	card	NN
cord-323756-atnrw9ew	78	26	domain	domain	NN
cord-323756-atnrw9ew	78	27	which	which	WDT
cord-323756-atnrw9ew	78	28	can	can	MD
cord-323756-atnrw9ew	78	29	subsequently	subsequently	RB
cord-323756-atnrw9ew	78	30	initiate	initiate	VB
cord-323756-atnrw9ew	78	31	signaling	signal	VBG
cord-323756-atnrw9ew	78	32	by	by	IN
cord-323756-atnrw9ew	78	33	association	association	NN
cord-323756-atnrw9ew	78	34	with	with	IN
cord-323756-atnrw9ew	78	35	MAVS	MAVS	NNP
cord-323756-atnrw9ew	78	36	(	(	-LRB-
cord-323756-atnrw9ew	78	37	30	30	CD
cord-323756-atnrw9ew	78	38	)	)	-RRB-
cord-323756-atnrw9ew	79	1	(	(	-LRB-
cord-323756-atnrw9ew	79	2	31	31	CD
cord-323756-atnrw9ew	79	3	)	)	-RRB-
cord-323756-atnrw9ew	79	4	(	(	-LRB-
cord-323756-atnrw9ew	79	5	32	32	CD
cord-323756-atnrw9ew	79	6	)	)	-RRB-
cord-323756-atnrw9ew	79	7	.	.	.
cord-323756-atnrw9ew	80	1	Despite	despite	IN
cord-323756-atnrw9ew	80	2	the	the	DT
cord-323756-atnrw9ew	80	3	increasing	increase	VBG
cord-323756-atnrw9ew	80	4	amount	amount	NN
cord-323756-atnrw9ew	80	5	of	of	IN
cord-323756-atnrw9ew	80	6	high	high	JJ
cord-323756-atnrw9ew	80	7	-	-	HYPH
cord-323756-atnrw9ew	80	8	resolution	resolution	NN
cord-323756-atnrw9ew	80	9	crystal	crystal	NN
cord-323756-atnrw9ew	80	10	data	datum	NNS
cord-323756-atnrw9ew	80	11	,	,	,
cord-323756-atnrw9ew	80	12	the	the	DT
cord-323756-atnrw9ew	80	13	consensus	consensus	NN
cord-323756-atnrw9ew	80	14	definition	definition	NN
cord-323756-atnrw9ew	80	15	of	of	IN
cord-323756-atnrw9ew	80	16	RIG	rig	NN
cord-323756-atnrw9ew	80	17	-	-	:
cord-323756-atnrw9ew	80	18	I	i	NN
cord-323756-atnrw9ew	80	19	ligand	ligand	NN
cord-323756-atnrw9ew	80	20	remains	remain	VBZ
cord-323756-atnrw9ew	80	21	controversial	controversial	JJ
cord-323756-atnrw9ew	80	22	.	.	.
cord-323756-atnrw9ew	81	1	Other	other	JJ
cord-323756-atnrw9ew	81	2	RIG-	RIG-	NNP
cord-323756-atnrw9ew	82	1	I	-PRON-	PRP
cord-323756-atnrw9ew	82	2	ligands	ligand	NNS
cord-323756-atnrw9ew	82	3	have	have	VBP
cord-323756-atnrw9ew	82	4	been	be	VBN
cord-323756-atnrw9ew	82	5	indeed	indeed	RB
cord-323756-atnrw9ew	82	6	described	describe	VBN
cord-323756-atnrw9ew	82	7	in	in	IN
cord-323756-atnrw9ew	82	8	the	the	DT
cord-323756-atnrw9ew	82	9	literature	literature	NN
cord-323756-atnrw9ew	82	10	including	include	VBG
cord-323756-atnrw9ew	82	11	long	long	RB
cord-323756-atnrw9ew	82	12	(	(	-LRB-
cord-323756-atnrw9ew	82	13	33	33	CD
cord-323756-atnrw9ew	82	14	)	)	-RRB-
cord-323756-atnrw9ew	82	15	or	or	CC
cord-323756-atnrw9ew	82	16	short	short	JJ
cord-323756-atnrw9ew	82	17	dsRNA	dsrna	NN
cord-323756-atnrw9ew	82	18	(	(	-LRB-
cord-323756-atnrw9ew	82	19	34	34	CD
cord-323756-atnrw9ew	82	20	)	)	-RRB-
cord-323756-atnrw9ew	82	21	(	(	-LRB-
cord-323756-atnrw9ew	82	22	35	35	CD
cord-323756-atnrw9ew	82	23	)	)	-RRB-
cord-323756-atnrw9ew	82	24	(	(	-LRB-
cord-323756-atnrw9ew	82	25	36	36	CD
cord-323756-atnrw9ew	82	26	)	)	-RRB-
cord-323756-atnrw9ew	82	27	lacking	lack	VBG
cord-323756-atnrw9ew	82	28	the	the	DT
cord-323756-atnrw9ew	82	29	5	5	CD
cord-323756-atnrw9ew	82	30	-ppp	-ppp	:
cord-323756-atnrw9ew	82	31	.	.	.
cord-323756-atnrw9ew	83	1	However	however	RB
cord-323756-atnrw9ew	83	2	,	,	,
cord-323756-atnrw9ew	83	3	thermodynamic	thermodynamic	JJ
cord-323756-atnrw9ew	83	4	analysis	analysis	NN
cord-323756-atnrw9ew	83	5	have	have	VBP
cord-323756-atnrw9ew	83	6	shown	show	VBN
cord-323756-atnrw9ew	83	7	that	that	IN
cord-323756-atnrw9ew	83	8	the	the	DT
cord-323756-atnrw9ew	83	9	full	full	JJ
cord-323756-atnrw9ew	83	10	-	-	HYPH
cord-323756-atnrw9ew	83	11	length	length	NN
cord-323756-atnrw9ew	83	12	human	human	JJ
cord-323756-atnrw9ew	83	13	RIG	rig	NN
cord-323756-atnrw9ew	83	14	-	-	:
cord-323756-atnrw9ew	83	15	I	-PRON-	PRP
cord-323756-atnrw9ew	83	16	protein	protein	NN
cord-323756-atnrw9ew	83	17	binds	bind	VBZ
cord-323756-atnrw9ew	83	18	5'-ppp	5'-ppp	CD
cord-323756-atnrw9ew	83	19	dsRNA	dsRNA	NNS
cord-323756-atnrw9ew	83	20	with	with	IN
cord-323756-atnrw9ew	83	21	126-fold	126-fold	CD
cord-323756-atnrw9ew	83	22	higher	high	JJR
cord-323756-atnrw9ew	83	23	affinity	affinity	NN
cord-323756-atnrw9ew	83	24	than	than	IN
cord-323756-atnrw9ew	83	25	5'-OH	5'-oh	CD
cord-323756-atnrw9ew	83	26	dsRNA	dsrna	NN
cord-323756-atnrw9ew	83	27	,	,	,
cord-323756-atnrw9ew	83	28	and	and	CC
cord-323756-atnrw9ew	83	29	dsRNA	dsrna	NN
cord-323756-atnrw9ew	83	30	with	with	IN
cord-323756-atnrw9ew	83	31	a	a	DT
cord-323756-atnrw9ew	83	32	361-fold	361-fold	CD
cord-323756-atnrw9ew	83	33	higher	high	JJR
cord-323756-atnrw9ew	83	34	affinity	affinity	NN
cord-323756-atnrw9ew	83	35	than	than	IN
cord-323756-atnrw9ew	83	36	short	short	JJ
cord-323756-atnrw9ew	83	37	single	single	JJ
cord-323756-atnrw9ew	83	38	stranded	strand	VBN
cord-323756-atnrw9ew	83	39	RNA	RNA	NNP
cord-323756-atnrw9ew	83	40	(	(	-LRB-
cord-323756-atnrw9ew	83	41	ssRNA	ssRNA	VBG
cord-323756-atnrw9ew	83	42	)	)	-RRB-
cord-323756-atnrw9ew	83	43	lacking	lack	VBG
cord-323756-atnrw9ew	83	44	secondary	secondary	JJ
cord-323756-atnrw9ew	83	45	structure	structure	NN
cord-323756-atnrw9ew	83	46	(	(	-LRB-
cord-323756-atnrw9ew	83	47	37	37	CD
cord-323756-atnrw9ew	83	48	)	)	-RRB-
cord-323756-atnrw9ew	83	49	.	.	.
cord-323756-atnrw9ew	84	1	Many	many	JJ
cord-323756-atnrw9ew	84	2	viral	viral	JJ
cord-323756-atnrw9ew	84	3	families	family	NNS
cord-323756-atnrw9ew	84	4	display	display	VBP
cord-323756-atnrw9ew	84	5	blunt	blunt	JJ
cord-323756-atnrw9ew	84	6	-	-	HYPH
cord-323756-atnrw9ew	84	7	end	end	NN
cord-323756-atnrw9ew	84	8	base	base	NN
cord-323756-atnrw9ew	84	9	-	-	HYPH
cord-323756-atnrw9ew	84	10	paired	pair	VBN
cord-323756-atnrw9ew	84	11	RNA	RNA	NNP
cord-323756-atnrw9ew	84	12	with	with	IN
cord-323756-atnrw9ew	84	13	a	a	DT
cord-323756-atnrw9ew	84	14	5	5	CD
cord-323756-atnrw9ew	84	15	-ppp	-ppp	:
cord-323756-atnrw9ew	84	16	,	,	,
cord-323756-atnrw9ew	84	17	directly	directly	RB
cord-323756-atnrw9ew	84	18	in	in	IN
cord-323756-atnrw9ew	84	19	their	-PRON-	PRP$
cord-323756-atnrw9ew	84	20	genomic	genomic	JJ
cord-323756-atnrw9ew	84	21	RNA	RNA	NNP
cord-323756-atnrw9ew	84	22	or	or	CC
cord-323756-atnrw9ew	84	23	in	in	IN
cord-323756-atnrw9ew	84	24	replication	replication	NN
cord-323756-atnrw9ew	84	25	intermediates	intermediate	NNS
cord-323756-atnrw9ew	84	26	.	.	.
cord-323756-atnrw9ew	85	1	Consistent	consistent	JJ
cord-323756-atnrw9ew	85	2	with	with	IN
cord-323756-atnrw9ew	85	3	this	this	DT
cord-323756-atnrw9ew	85	4	notion	notion	NN
cord-323756-atnrw9ew	85	5	,	,	,
cord-323756-atnrw9ew	85	6	RIG	rig	NN
cord-323756-atnrw9ew	85	7	-	-	:
cord-323756-atnrw9ew	85	8	I	-PRON-	PRP
cord-323756-atnrw9ew	85	9	has	have	VBZ
cord-323756-atnrw9ew	85	10	been	be	VBN
cord-323756-atnrw9ew	85	11	shown	show	VBN
cord-323756-atnrw9ew	85	12	to	to	TO
cord-323756-atnrw9ew	85	13	be	be	VB
cord-323756-atnrw9ew	85	14	involved	involve	VBN
cord-323756-atnrw9ew	85	15	in	in	IN
cord-323756-atnrw9ew	85	16	the	the	DT
cord-323756-atnrw9ew	85	17	recognition	recognition	NN
cord-323756-atnrw9ew	85	18	of	of	IN
cord-323756-atnrw9ew	85	19	many	many	JJ
cord-323756-atnrw9ew	85	20	viruses	virus	NNS
cord-323756-atnrw9ew	85	21	,	,	,
cord-323756-atnrw9ew	85	22	either	either	CC
cord-323756-atnrw9ew	85	23	antisense	antisense	NN
cord-323756-atnrw9ew	85	24	(	(	-LRB-
cord-323756-atnrw9ew	85	25	−)ssRNA	−)ssRNA	``
cord-323756-atnrw9ew	85	26	viruses	virus	NNS
cord-323756-atnrw9ew	85	27	(	(	-LRB-
cord-323756-atnrw9ew	85	28	38	38	CD
cord-323756-atnrw9ew	85	29	,	,	,
cord-323756-atnrw9ew	85	30	39	39	CD
cord-323756-atnrw9ew	85	31	)	)	-RRB-
cord-323756-atnrw9ew	85	32	or	or	CC
cord-323756-atnrw9ew	85	33	sense	sense	NN
cord-323756-atnrw9ew	85	34	(	(	-LRB-
cord-323756-atnrw9ew	85	35	+	+	NN
cord-323756-atnrw9ew	85	36	)	)	-RRB-
cord-323756-atnrw9ew	86	1	ssRNA	ssrna	UH
cord-323756-atnrw9ew	86	2	/	/	,
cord-323756-atnrw9ew	86	3	dsRNA	dsrna	NN
cord-323756-atnrw9ew	86	4	viruses	virus	NNS
cord-323756-atnrw9ew	86	5	(	(	-LRB-
cord-323756-atnrw9ew	86	6	40	40	CD
cord-323756-atnrw9ew	86	7	,	,	,
cord-323756-atnrw9ew	86	8	41	41	CD
cord-323756-atnrw9ew	86	9	)	)	-RRB-
cord-323756-atnrw9ew	86	10	.	.	.
cord-323756-atnrw9ew	87	1	Notably	notably	RB
cord-323756-atnrw9ew	87	2	RIG	rig	NN
cord-323756-atnrw9ew	87	3	-	-	:
cord-323756-atnrw9ew	87	4	I	-PRON-	PRP
cord-323756-atnrw9ew	87	5	can	can	MD
cord-323756-atnrw9ew	87	6	detect	detect	VB
cord-323756-atnrw9ew	87	7	panhandle	panhandle	JJ
cord-323756-atnrw9ew	87	8	structures	structure	NNS
cord-323756-atnrw9ew	87	9	found	find	VBN
cord-323756-atnrw9ew	87	10	in	in	IN
cord-323756-atnrw9ew	87	11	LaCrosse	lacrosse	NN
cord-323756-atnrw9ew	87	12	viral	viral	JJ
cord-323756-atnrw9ew	87	13	particles	particle	NNS
cord-323756-atnrw9ew	87	14	(	(	-LRB-
cord-323756-atnrw9ew	87	15	39	39	CD
cord-323756-atnrw9ew	87	16	)	)	-RRB-
cord-323756-atnrw9ew	87	17	or	or	CC
cord-323756-atnrw9ew	87	18	in	in	IN
cord-323756-atnrw9ew	87	19	influenza	influenza	JJ
cord-323756-atnrw9ew	87	20	genomic	genomic	JJ
cord-323756-atnrw9ew	87	21	RNA	RNA	NNP
cord-323756-atnrw9ew	87	22	(	(	-LRB-
cord-323756-atnrw9ew	87	23	28	28	CD
cord-323756-atnrw9ew	87	24	,	,	,
cord-323756-atnrw9ew	87	25	38	38	CD
cord-323756-atnrw9ew	87	26	)	)	-RRB-
cord-323756-atnrw9ew	87	27	.	.	.
cord-323756-atnrw9ew	88	1	Sendai	Sendai	NNP
cord-323756-atnrw9ew	88	2	Virus	Virus	NNP
cord-323756-atnrw9ew	88	3	(	(	-LRB-
cord-323756-atnrw9ew	88	4	SeV	sev	NN
cord-323756-atnrw9ew	88	5	)	)	-RRB-
cord-323756-atnrw9ew	88	6	and	and	CC
cord-323756-atnrw9ew	88	7	other	other	JJ
cord-323756-atnrw9ew	88	8	Mononegavirales	Mononegavirales	NNPS
cord-323756-atnrw9ew	88	9	produce	produce	VBP
cord-323756-atnrw9ew	88	10	defective	defective	JJ
cord-323756-atnrw9ew	88	11	interfering	interfere	VBG
cord-323756-atnrw9ew	88	12	(	(	-LRB-
cord-323756-atnrw9ew	88	13	DI	DI	NNP
cord-323756-atnrw9ew	88	14	)	)	-RRB-
cord-323756-atnrw9ew	88	15	viral	viral	JJ
cord-323756-atnrw9ew	88	16	genomes	genome	NNS
cord-323756-atnrw9ew	88	17	containing	contain	VBG
cord-323756-atnrw9ew	88	18	panhandle	panhandle	NN
cord-323756-atnrw9ew	88	19	structures	structure	NNS
cord-323756-atnrw9ew	88	20	that	that	WDT
cord-323756-atnrw9ew	88	21	activate	activate	VBP
cord-323756-atnrw9ew	88	22	RIG	rig	NN
cord-323756-atnrw9ew	88	23	-	-	:
cord-323756-atnrw9ew	88	24	I	-PRON-	PRP
cord-323756-atnrw9ew	88	25	in	in	IN
cord-323756-atnrw9ew	88	26	infected	infected	JJ
cord-323756-atnrw9ew	88	27	cells	cell	NNS
cord-323756-atnrw9ew	88	28	(	(	-LRB-
cord-323756-atnrw9ew	88	29	42	42	CD
cord-323756-atnrw9ew	88	30	)	)	-RRB-
cord-323756-atnrw9ew	88	31	.	.	.
cord-323756-atnrw9ew	89	1	Retinoic	retinoic	JJ
cord-323756-atnrw9ew	89	2	acid	acid	NN
cord-323756-atnrw9ew	89	3	-	-	HYPH
cord-323756-atnrw9ew	89	4	inducible	inducible	JJ
cord-323756-atnrw9ew	89	5	gene	gene	NN
cord-323756-atnrw9ew	89	6	I	-PRON-	PRP
cord-323756-atnrw9ew	89	7	recognition	recognition	NN
cord-323756-atnrw9ew	89	8	has	have	VBZ
cord-323756-atnrw9ew	89	9	not	not	RB
cord-323756-atnrw9ew	89	10	been	be	VBN
cord-323756-atnrw9ew	89	11	limited	limit	VBN
cord-323756-atnrw9ew	89	12	to	to	IN
cord-323756-atnrw9ew	89	13	RNA	RNA	NNP
cord-323756-atnrw9ew	89	14	virus	virus	NN
cord-323756-atnrw9ew	89	15	since	since	IN
cord-323756-atnrw9ew	89	16	RIG	rig	NN
cord-323756-atnrw9ew	89	17	-	-	:
cord-323756-atnrw9ew	89	18	I	-PRON-	PRP
cord-323756-atnrw9ew	89	19	is	be	VBZ
cord-323756-atnrw9ew	89	20	involved	involve	VBN
cord-323756-atnrw9ew	89	21	in	in	IN
cord-323756-atnrw9ew	89	22	recognition	recognition	NN
cord-323756-atnrw9ew	89	23	of	of	IN
cord-323756-atnrw9ew	89	24	DNA	dna	NN
cord-323756-atnrw9ew	89	25	viruses	virus	NNS
cord-323756-atnrw9ew	89	26	,	,	,
cord-323756-atnrw9ew	89	27	such	such	JJ
cord-323756-atnrw9ew	89	28	as	as	IN
cord-323756-atnrw9ew	89	29	Epstein	Epstein	NNP
cord-323756-atnrw9ew	89	30	-	-	HYPH
cord-323756-atnrw9ew	89	31	Barr	Barr	NNP
cord-323756-atnrw9ew	89	32	virus	virus	NN
cord-323756-atnrw9ew	89	33	or	or	CC
cord-323756-atnrw9ew	89	34	adenovirus	adenovirus	NN
cord-323756-atnrw9ew	89	35	through	through	IN
cord-323756-atnrw9ew	89	36	the	the	DT
cord-323756-atnrw9ew	89	37	RNA	RNA	NNP
cord-323756-atnrw9ew	89	38	polymerase	polymerase	NN
cord-323756-atnrw9ew	89	39	III	iii	CD
cord-323756-atnrw9ew	89	40	pathway	pathway	NN
cord-323756-atnrw9ew	89	41	(	(	-LRB-
cord-323756-atnrw9ew	89	42	18	18	CD
cord-323756-atnrw9ew	89	43	,	,	,
cord-323756-atnrw9ew	89	44	43	43	CD
cord-323756-atnrw9ew	89	45	,	,	,
cord-323756-atnrw9ew	89	46	44	44	CD
cord-323756-atnrw9ew	89	47	)	)	-RRB-
cord-323756-atnrw9ew	89	48	.	.	.
cord-323756-atnrw9ew	90	1	Moreover	moreover	RB
cord-323756-atnrw9ew	90	2	,	,	,
cord-323756-atnrw9ew	90	3	RIG	rig	NN
cord-323756-atnrw9ew	90	4	-	-	:
cord-323756-atnrw9ew	90	5	I	-PRON-	PRP
cord-323756-atnrw9ew	90	6	is	be	VBZ
cord-323756-atnrw9ew	90	7	also	also	RB
cord-323756-atnrw9ew	90	8	able	able	JJ
cord-323756-atnrw9ew	90	9	to	to	TO
cord-323756-atnrw9ew	90	10	detect	detect	VB
cord-323756-atnrw9ew	90	11	bacterial	bacterial	JJ
cord-323756-atnrw9ew	90	12	infections	infection	NNS
cord-323756-atnrw9ew	90	13	.	.	.
cord-323756-atnrw9ew	91	1	Bacterial	bacterial	JJ
cord-323756-atnrw9ew	91	2	mRNA	mRNA	NNP
cord-323756-atnrw9ew	91	3	are	be	VBP
cord-323756-atnrw9ew	91	4	not	not	RB
cord-323756-atnrw9ew	91	5	capped	cap	VBN
cord-323756-atnrw9ew	91	6	and	and	CC
cord-323756-atnrw9ew	91	7	it	-PRON-	PRP
cord-323756-atnrw9ew	91	8	has	have	VBZ
cord-323756-atnrw9ew	91	9	been	be	VBN
cord-323756-atnrw9ew	91	10	estimated	estimate	VBN
cord-323756-atnrw9ew	91	11	that	that	IN
cord-323756-atnrw9ew	91	12	approximately	approximately	RB
cord-323756-atnrw9ew	91	13	40	40	CD
cord-323756-atnrw9ew	91	14	%	%	NN
cord-323756-atnrw9ew	91	15	of	of	IN
cord-323756-atnrw9ew	91	16	RNA	RNA	NNP
cord-323756-atnrw9ew	91	17	oligonucleotides	oligonucleotide	NNS
cord-323756-atnrw9ew	91	18	in	in	IN
cord-323756-atnrw9ew	91	19	E.	E.	NNP
cord-323756-atnrw9ew	91	20	coli	coli	NNS
cord-323756-atnrw9ew	91	21	have	have	VBP
cord-323756-atnrw9ew	91	22	a	a	DT
cord-323756-atnrw9ew	91	23	5	5	CD
cord-323756-atnrw9ew	91	24	-ppp	-ppp	:
cord-323756-atnrw9ew	91	25	(	(	-LRB-
cord-323756-atnrw9ew	91	26	45	45	CD
cord-323756-atnrw9ew	91	27	)	)	-RRB-
cord-323756-atnrw9ew	91	28	.	.	.
cord-323756-atnrw9ew	92	1	Reports	report	NNS
cord-323756-atnrw9ew	92	2	in	in	IN
cord-323756-atnrw9ew	92	3	the	the	DT
cord-323756-atnrw9ew	92	4	literature	literature	NN
cord-323756-atnrw9ew	92	5	describe	describe	VBP
cord-323756-atnrw9ew	92	6	sensing	sensing	NN
cord-323756-atnrw9ew	92	7	of	of	IN
cord-323756-atnrw9ew	92	8	L.	L.	NNP
cord-323756-atnrw9ew	92	9	monocytogenes	monocytogenes	NNP
cord-323756-atnrw9ew	92	10	secreted	secrete	VBD
cord-323756-atnrw9ew	92	11	RNA	RNA	NNP
cord-323756-atnrw9ew	92	12	(	(	-LRB-
cord-323756-atnrw9ew	92	13	15	15	CD
cord-323756-atnrw9ew	92	14	,	,	,
cord-323756-atnrw9ew	92	15	16	16	CD
cord-323756-atnrw9ew	92	16	)	)	-RRB-
cord-323756-atnrw9ew	92	17	or	or	CC
cord-323756-atnrw9ew	92	18	purified	purify	VBN
cord-323756-atnrw9ew	92	19	Legionella	Legionella	NNP
cord-323756-atnrw9ew	92	20	(	(	-LRB-
cord-323756-atnrw9ew	92	21	17	17	CD
cord-323756-atnrw9ew	92	22	)	)	-RRB-
cord-323756-atnrw9ew	92	23	and	and	CC
cord-323756-atnrw9ew	92	24	Helicobacter	Helicobacter	NNP
cord-323756-atnrw9ew	92	25	pylori	pylori	NN
cord-323756-atnrw9ew	92	26	RNA	RNA	NNP
cord-323756-atnrw9ew	92	27	(	(	-LRB-
cord-323756-atnrw9ew	92	28	46	46	CD
cord-323756-atnrw9ew	92	29	)	)	-RRB-
cord-323756-atnrw9ew	92	30	by	by	IN
cord-323756-atnrw9ew	93	1	RIG	rig	NN
cord-323756-atnrw9ew	93	2	-	-	HYPH
cord-323756-atnrw9ew	93	3	I.	I.	NNP
cord-323756-atnrw9ew	93	4	Finally	finally	RB
cord-323756-atnrw9ew	93	5	,	,	,
cord-323756-atnrw9ew	93	6	RIG	rig	NN
cord-323756-atnrw9ew	93	7	-	-	:
cord-323756-atnrw9ew	93	8	I	-PRON-	PRP
cord-323756-atnrw9ew	93	9	can	can	MD
cord-323756-atnrw9ew	93	10	also	also	RB
cord-323756-atnrw9ew	93	11	sense	sense	VB
cord-323756-atnrw9ew	93	12	Shigella	Shigella	NNP
cord-323756-atnrw9ew	93	13	flexneri	flexneri	NN
cord-323756-atnrw9ew	93	14	infection	infection	NN
cord-323756-atnrw9ew	93	15	in	in	IN
cord-323756-atnrw9ew	93	16	macrophages	macrophage	NNS
cord-323756-atnrw9ew	93	17	through	through	IN
cord-323756-atnrw9ew	93	18	the	the	DT
cord-323756-atnrw9ew	93	19	RNA	RNA	NNP
cord-323756-atnrw9ew	93	20	polymerase	polymerase	NN
cord-323756-atnrw9ew	93	21	III	iii	CD
cord-323756-atnrw9ew	93	22	pathway	pathway	NN
cord-323756-atnrw9ew	93	23	(	(	-LRB-
cord-323756-atnrw9ew	93	24	47	47	CD
cord-323756-atnrw9ew	93	25	)	)	-RRB-
cord-323756-atnrw9ew	93	26	.	.	.
cord-323756-atnrw9ew	94	1	Melanoma	melanoma	NN
cord-323756-atnrw9ew	94	2	differentiation	differentiation	NN
cord-323756-atnrw9ew	94	3	factor	factor	NN
cord-323756-atnrw9ew	94	4	5	5	CD
cord-323756-atnrw9ew	94	5	ligand	ligand	NN
cord-323756-atnrw9ew	94	6	is	be	VBZ
cord-323756-atnrw9ew	94	7	less	less	RBR
cord-323756-atnrw9ew	94	8	characterized	characterize	VBN
cord-323756-atnrw9ew	94	9	than	than	IN
cord-323756-atnrw9ew	94	10	RIG	rig	NN
cord-323756-atnrw9ew	94	11	-	-	HYPH
cord-323756-atnrw9ew	94	12	I.	i.	NN
cord-323756-atnrw9ew	94	13	Using	use	VBG
cord-323756-atnrw9ew	94	14	poly(I	poly(I	NNP
cord-323756-atnrw9ew	94	15	:	:	:
cord-323756-atnrw9ew	94	16	C	C	NNP
cord-323756-atnrw9ew	94	17	)	)	-RRB-
cord-323756-atnrw9ew	94	18	as	as	IN
cord-323756-atnrw9ew	94	19	a	a	DT
cord-323756-atnrw9ew	94	20	synthetic	synthetic	JJ
cord-323756-atnrw9ew	94	21	dsRNA	dsrna	NN
cord-323756-atnrw9ew	94	22	mimic	mimic	VB
cord-323756-atnrw9ew	94	23	,	,	,
cord-323756-atnrw9ew	94	24	studies	study	NNS
cord-323756-atnrw9ew	94	25	have	have	VBP
cord-323756-atnrw9ew	94	26	shown	show	VBN
cord-323756-atnrw9ew	94	27	that	that	IN
cord-323756-atnrw9ew	94	28	MDA5	MDA5	NNP
cord-323756-atnrw9ew	94	29	binds	bind	VBZ
cord-323756-atnrw9ew	94	30	long	long	RB
cord-323756-atnrw9ew	94	31	,	,	,
cord-323756-atnrw9ew	94	32	but	but	CC
cord-323756-atnrw9ew	94	33	not	not	RB
cord-323756-atnrw9ew	94	34	short	short	JJ
cord-323756-atnrw9ew	94	35	dsRNA	dsRNA	NNS
cord-323756-atnrw9ew	94	36	(	(	-LRB-
cord-323756-atnrw9ew	94	37	35	35	CD
cord-323756-atnrw9ew	94	38	,	,	,
cord-323756-atnrw9ew	94	39	40	40	CD
cord-323756-atnrw9ew	94	40	,	,	,
cord-323756-atnrw9ew	94	41	48	48	CD
cord-323756-atnrw9ew	94	42	)	)	-RRB-
cord-323756-atnrw9ew	94	43	.	.	.
cord-323756-atnrw9ew	95	1	Structural	structural	JJ
cord-323756-atnrw9ew	95	2	analyses	analysis	NNS
cord-323756-atnrw9ew	95	3	have	have	VBP
cord-323756-atnrw9ew	95	4	demonstrated	demonstrate	VBN
cord-323756-atnrw9ew	95	5	that	that	IN
cord-323756-atnrw9ew	95	6	MDA5	MDA5	NNP
cord-323756-atnrw9ew	95	7	specifically	specifically	RB
cord-323756-atnrw9ew	95	8	recognizes	recognize	VBZ
cord-323756-atnrw9ew	95	9	the	the	DT
cord-323756-atnrw9ew	95	10	internal	internal	JJ
cord-323756-atnrw9ew	95	11	duplex	duplex	JJ
cord-323756-atnrw9ew	95	12	structure	structure	NN
cord-323756-atnrw9ew	95	13	of	of	IN
cord-323756-atnrw9ew	95	14	dsRNA	dsrna	NN
cord-323756-atnrw9ew	95	15	and	and	CC
cord-323756-atnrw9ew	95	16	uses	use	VBZ
cord-323756-atnrw9ew	95	17	it	-PRON-	PRP
cord-323756-atnrw9ew	95	18	as	as	IN
cord-323756-atnrw9ew	95	19	a	a	DT
cord-323756-atnrw9ew	95	20	platform	platform	NN
cord-323756-atnrw9ew	95	21	to	to	TO
cord-323756-atnrw9ew	95	22	stack	stack	VB
cord-323756-atnrw9ew	95	23	along	along	RP
cord-323756-atnrw9ew	95	24	dsRNA	dsrna	NN
cord-323756-atnrw9ew	95	25	in	in	IN
cord-323756-atnrw9ew	95	26	a	a	DT
cord-323756-atnrw9ew	95	27	head	head	NN
cord-323756-atnrw9ew	95	28	-	-	HYPH
cord-323756-atnrw9ew	95	29	to	to	IN
cord-323756-atnrw9ew	95	30	-	-	HYPH
cord-323756-atnrw9ew	95	31	tail	tail	NN
cord-323756-atnrw9ew	95	32	arrangement	arrangement	NN
cord-323756-atnrw9ew	95	33	.	.	.
cord-323756-atnrw9ew	96	1	This	this	DT
cord-323756-atnrw9ew	96	2	mechanism	mechanism	NN
cord-323756-atnrw9ew	96	3	promotes	promote	VBZ
cord-323756-atnrw9ew	96	4	stochastic	stochastic	JJ
cord-323756-atnrw9ew	96	5	assembly	assembly	NN
cord-323756-atnrw9ew	96	6	of	of	IN
cord-323756-atnrw9ew	96	7	the	the	DT
cord-323756-atnrw9ew	96	8	tandem	tandem	JJ
cord-323756-atnrw9ew	96	9	CARD	card	NN
cord-323756-atnrw9ew	96	10	oligomers	oligomer	NNS
cord-323756-atnrw9ew	96	11	that	that	WDT
cord-323756-atnrw9ew	96	12	activates	activate	VBZ
cord-323756-atnrw9ew	96	13	the	the	DT
cord-323756-atnrw9ew	96	14	signaling	signal	VBG
cord-323756-atnrw9ew	96	15	adaptor	adaptor	NN
cord-323756-atnrw9ew	96	16	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	96	17	(	(	-LRB-
cord-323756-atnrw9ew	96	18	49	49	CD
cord-323756-atnrw9ew	96	19	)	)	-RRB-
cord-323756-atnrw9ew	96	20	.	.	.
cord-323756-atnrw9ew	97	1	Melanoma	melanoma	NN
cord-323756-atnrw9ew	97	2	differentiation	differentiation	NN
cord-323756-atnrw9ew	97	3	factor	factor	NN
cord-323756-atnrw9ew	97	4	5	5	CD
cord-323756-atnrw9ew	97	5	detects	detect	VBZ
cord-323756-atnrw9ew	97	6	infection	infection	NN
cord-323756-atnrw9ew	97	7	by	by	IN
cord-323756-atnrw9ew	97	8	viral	viral	JJ
cord-323756-atnrw9ew	97	9	families	family	NNS
cord-323756-atnrw9ew	97	10	known	know	VBN
cord-323756-atnrw9ew	97	11	to	to	TO
cord-323756-atnrw9ew	97	12	produce	produce	VB
cord-323756-atnrw9ew	97	13	long	long	JJ
cord-323756-atnrw9ew	97	14	dsRNA	dsrna	NN
cord-323756-atnrw9ew	97	15	structures	structure	NNS
cord-323756-atnrw9ew	97	16	during	during	IN
cord-323756-atnrw9ew	97	17	their	-PRON-	PRP$
cord-323756-atnrw9ew	97	18	replication	replication	NN
cord-323756-atnrw9ew	97	19	cycle	cycle	NN
cord-323756-atnrw9ew	97	20	,	,	,
cord-323756-atnrw9ew	97	21	including	include	VBG
cord-323756-atnrw9ew	97	22	(	(	-LRB-
cord-323756-atnrw9ew	97	23	+	+	CC
cord-323756-atnrw9ew	98	1	)	)	-RRB-
cord-323756-atnrw9ew	98	2	ssRNA	ssRNA	``
cord-323756-atnrw9ew	98	3	viruses	virus	NNS
cord-323756-atnrw9ew	98	4	like	like	IN
cord-323756-atnrw9ew	98	5	picornaviruses	picornavirus	NNS
cord-323756-atnrw9ew	98	6	,	,	,
cord-323756-atnrw9ew	98	7	dsRNA	dsrna	NN
cord-323756-atnrw9ew	98	8	viruses	virus	NNS
cord-323756-atnrw9ew	98	9	like	like	IN
cord-323756-atnrw9ew	98	10	reoviruses	reovirus	NNS
cord-323756-atnrw9ew	98	11	,	,	,
cord-323756-atnrw9ew	98	12	or	or	CC
cord-323756-atnrw9ew	98	13	DNA	dna	NN
cord-323756-atnrw9ew	98	14	viruses	virus	NNS
cord-323756-atnrw9ew	98	15	like	like	IN
cord-323756-atnrw9ew	98	16	poxviruses	poxvirus	NNS
cord-323756-atnrw9ew	98	17	(	(	-LRB-
cord-323756-atnrw9ew	98	18	35	35	CD
cord-323756-atnrw9ew	98	19	,	,	,
cord-323756-atnrw9ew	98	20	(	(	-LRB-
cord-323756-atnrw9ew	98	21	50	50	CD
cord-323756-atnrw9ew	98	22	)	)	-RRB-
cord-323756-atnrw9ew	98	23	(	(	-LRB-
cord-323756-atnrw9ew	98	24	51	51	CD
cord-323756-atnrw9ew	98	25	)	)	-RRB-
cord-323756-atnrw9ew	98	26	(	(	-LRB-
cord-323756-atnrw9ew	98	27	52	52	CD
cord-323756-atnrw9ew	98	28	)	)	-RRB-
cord-323756-atnrw9ew	98	29	(	(	-LRB-
cord-323756-atnrw9ew	98	30	53	53	CD
cord-323756-atnrw9ew	98	31	)	)	-RRB-
cord-323756-atnrw9ew	98	32	.	.	.
cord-323756-atnrw9ew	99	1	In	in	IN
cord-323756-atnrw9ew	99	2	the	the	DT
cord-323756-atnrw9ew	99	3	case	case	NN
cord-323756-atnrw9ew	99	4	of	of	IN
cord-323756-atnrw9ew	99	5	(	(	-LRB-
cord-323756-atnrw9ew	99	6	+	+	NNS
cord-323756-atnrw9ew	99	7	)	)	-RRB-
cord-323756-atnrw9ew	99	8	ssRNA	ssRNA	-RRB-
cord-323756-atnrw9ew	99	9	virus	virus	NN
cord-323756-atnrw9ew	99	10	infection	infection	NN
cord-323756-atnrw9ew	99	11	,	,	,
cord-323756-atnrw9ew	99	12	fluorescent	fluorescent	JJ
cord-323756-atnrw9ew	99	13	imaging	imaging	NN
cord-323756-atnrw9ew	99	14	studies	study	NNS
cord-323756-atnrw9ew	99	15	have	have	VBP
cord-323756-atnrw9ew	99	16	confirmed	confirm	VBN
cord-323756-atnrw9ew	99	17	that	that	IN
cord-323756-atnrw9ew	99	18	MDA5	MDA5	NNP
cord-323756-atnrw9ew	99	19	recognizes	recognize	VBZ
cord-323756-atnrw9ew	99	20	preferentially	preferentially	RB
cord-323756-atnrw9ew	99	21	the	the	DT
cord-323756-atnrw9ew	99	22	dsRNA	dsrna	NN
cord-323756-atnrw9ew	99	23	generated	generate	VBN
cord-323756-atnrw9ew	99	24	during	during	IN
cord-323756-atnrw9ew	99	25	the	the	DT
cord-323756-atnrw9ew	99	26	replication	replication	NN
cord-323756-atnrw9ew	99	27	of	of	IN
cord-323756-atnrw9ew	99	28	these	these	DT
cord-323756-atnrw9ew	99	29	viruses	virus	NNS
cord-323756-atnrw9ew	99	30	,	,	,
cord-323756-atnrw9ew	99	31	but	but	CC
cord-323756-atnrw9ew	99	32	not	not	RB
cord-323756-atnrw9ew	99	33	the	the	DT
cord-323756-atnrw9ew	99	34	genomic	genomic	NN
cord-323756-atnrw9ew	99	35	ssRNA	ssrna	NN
cord-323756-atnrw9ew	99	36	(	(	-LRB-
cord-323756-atnrw9ew	99	37	54	54	CD
cord-323756-atnrw9ew	99	38	)	)	-RRB-
cord-323756-atnrw9ew	99	39	.	.	.
cord-323756-atnrw9ew	100	1	Prior	prior	RB
cord-323756-atnrw9ew	100	2	to	to	IN
cord-323756-atnrw9ew	100	3	the	the	DT
cord-323756-atnrw9ew	100	4	structural	structural	JJ
cord-323756-atnrw9ew	100	5	study	study	NN
cord-323756-atnrw9ew	100	6	mentioned	mention	VBN
cord-323756-atnrw9ew	100	7	above	above	RB
cord-323756-atnrw9ew	100	8	,	,	,
cord-323756-atnrw9ew	100	9	multiple	multiple	JJ
cord-323756-atnrw9ew	100	10	observations	observation	NNS
cord-323756-atnrw9ew	100	11	raised	raise	VBD
cord-323756-atnrw9ew	100	12	the	the	DT
cord-323756-atnrw9ew	100	13	possibility	possibility	NN
cord-323756-atnrw9ew	100	14	that	that	IN
cord-323756-atnrw9ew	100	15	there	there	EX
cord-323756-atnrw9ew	100	16	may	may	MD
cord-323756-atnrw9ew	100	17	exist	exist	VB
cord-323756-atnrw9ew	100	18	additional	additional	JJ
cord-323756-atnrw9ew	100	19	MDA5	mda5	JJ
cord-323756-atnrw9ew	100	20	ligands	ligand	NNS
cord-323756-atnrw9ew	100	21	,	,	,
cord-323756-atnrw9ew	100	22	different	different	JJ
cord-323756-atnrw9ew	100	23	from	from	IN
cord-323756-atnrw9ew	100	24	the	the	DT
cord-323756-atnrw9ew	100	25	consensus	consensus	NN
cord-323756-atnrw9ew	100	26	long	long	JJ
cord-323756-atnrw9ew	100	27	dsRNA	dsrna	NN
cord-323756-atnrw9ew	100	28	.	.	.
cord-323756-atnrw9ew	101	1	Thus	thus	RB
cord-323756-atnrw9ew	101	2	,	,	,
cord-323756-atnrw9ew	101	3	a	a	DT
cord-323756-atnrw9ew	101	4	study	study	NN
cord-323756-atnrw9ew	101	5	has	have	VBZ
cord-323756-atnrw9ew	101	6	shown	show	VBN
cord-323756-atnrw9ew	101	7	that	that	IN
cord-323756-atnrw9ew	101	8	MDA5	MDA5	NNP
cord-323756-atnrw9ew	101	9	cooperates	cooperate	VBZ
cord-323756-atnrw9ew	101	10	with	with	IN
cord-323756-atnrw9ew	101	11	the	the	DT
cord-323756-atnrw9ew	101	12	ribonuclease	ribonuclease	NN
cord-323756-atnrw9ew	101	13	RNase	RNase	NNP
cord-323756-atnrw9ew	101	14	L	L	NNP
cord-323756-atnrw9ew	101	15	to	to	TO
cord-323756-atnrw9ew	101	16	induce	induce	VB
cord-323756-atnrw9ew	101	17	IFN	IFN	NNP
cord-323756-atnrw9ew	101	18	-	-	HYPH
cord-323756-atnrw9ew	101	19	I	-PRON-	PRP
cord-323756-atnrw9ew	101	20	in	in	IN
cord-323756-atnrw9ew	101	21	response	response	NN
cord-323756-atnrw9ew	101	22	to	to	IN
cord-323756-atnrw9ew	101	23	a	a	DT
cord-323756-atnrw9ew	101	24	viral	viral	JJ
cord-323756-atnrw9ew	101	25	mRNA	mrna	NN
cord-323756-atnrw9ew	101	26	from	from	IN
cord-323756-atnrw9ew	101	27	parainfluenza	parainfluenza	NNP
cord-323756-atnrw9ew	101	28	5	5	CD
cord-323756-atnrw9ew	101	29	virus	virus	NN
cord-323756-atnrw9ew	101	30	(	(	-LRB-
cord-323756-atnrw9ew	101	31	55	55	CD
cord-323756-atnrw9ew	101	32	)	)	-RRB-
cord-323756-atnrw9ew	101	33	.	.	.
cord-323756-atnrw9ew	102	1	Interestingly	interestingly	RB
cord-323756-atnrw9ew	102	2	,	,	,
cord-323756-atnrw9ew	102	3	RNase	RNase	NNP
cord-323756-atnrw9ew	102	4	L	L	NNP
cord-323756-atnrw9ew	102	5	converts	convert	VBZ
cord-323756-atnrw9ew	102	6	RNA	RNA	NNP
cord-323756-atnrw9ew	102	7	into	into	IN
cord-323756-atnrw9ew	102	8	small	small	JJ
cord-323756-atnrw9ew	102	9	RNA	RNA	NNP
cord-323756-atnrw9ew	102	10	products	product	NNS
cord-323756-atnrw9ew	102	11	,	,	,
cord-323756-atnrw9ew	102	12	with	with	IN
cord-323756-atnrw9ew	102	13	shorter	short	JJR
cord-323756-atnrw9ew	102	14	length	length	NN
cord-323756-atnrw9ew	102	15	than	than	IN
cord-323756-atnrw9ew	102	16	the	the	DT
cord-323756-atnrw9ew	102	17	current	current	JJ
cord-323756-atnrw9ew	102	18	MDA5	MDA5	NNP
cord-323756-atnrw9ew	102	19	www.frontiersin.org	www.frontiersin.org	IN
cord-323756-atnrw9ew	102	20	ligand	ligand	NN
cord-323756-atnrw9ew	102	21	definition	definition	NN
cord-323756-atnrw9ew	102	22	(	(	-LRB-
cord-323756-atnrw9ew	102	23	56	56	CD
cord-323756-atnrw9ew	102	24	)	)	-RRB-
cord-323756-atnrw9ew	102	25	.	.	.
cord-323756-atnrw9ew	103	1	Another	another	DT
cord-323756-atnrw9ew	103	2	work	work	NN
cord-323756-atnrw9ew	103	3	published	publish	VBD
cord-323756-atnrw9ew	103	4	the	the	DT
cord-323756-atnrw9ew	103	5	same	same	JJ
cord-323756-atnrw9ew	103	6	year	year	NN
cord-323756-atnrw9ew	103	7	has	have	VBZ
cord-323756-atnrw9ew	103	8	shown	show	VBN
cord-323756-atnrw9ew	103	9	that	that	IN
cord-323756-atnrw9ew	103	10	mRNA	mrna	NN
cord-323756-atnrw9ew	103	11	lacking	lack	VBG
cord-323756-atnrw9ew	103	12	2'-O	2'-o	CD
cord-323756-atnrw9ew	103	13	-	-	HYPH
cord-323756-atnrw9ew	103	14	methylation	methylation	NN
cord-323756-atnrw9ew	103	15	at	at	IN
cord-323756-atnrw9ew	103	16	their	-PRON-	PRP$
cord-323756-atnrw9ew	103	17	5	5	CD
cord-323756-atnrw9ew	103	18	'	'	''
cord-323756-atnrw9ew	103	19	cap	cap	NN
cord-323756-atnrw9ew	103	20	structure	structure	NN
cord-323756-atnrw9ew	103	21	induces	induce	VBZ
cord-323756-atnrw9ew	103	22	production	production	NN
cord-323756-atnrw9ew	103	23	of	of	IN
cord-323756-atnrw9ew	103	24	IFN	IFN	NNP
cord-323756-atnrw9ew	103	25	-	-	HYPH
cord-323756-atnrw9ew	103	26	I	I	NNP
cord-323756-atnrw9ew	103	27	through	through	IN
cord-323756-atnrw9ew	103	28	MDA5	MDA5	NNP
cord-323756-atnrw9ew	103	29	activation	activation	NN
cord-323756-atnrw9ew	103	30	(	(	-LRB-
cord-323756-atnrw9ew	103	31	57	57	CD
cord-323756-atnrw9ew	103	32	)	)	-RRB-
cord-323756-atnrw9ew	103	33	.	.	.
cord-323756-atnrw9ew	104	1	However	however	RB
cord-323756-atnrw9ew	104	2	,	,	,
cord-323756-atnrw9ew	104	3	the	the	DT
cord-323756-atnrw9ew	104	4	data	datum	NNS
cord-323756-atnrw9ew	104	5	published	publish	VBN
cord-323756-atnrw9ew	104	6	,	,	,
cord-323756-atnrw9ew	104	7	which	which	WDT
cord-323756-atnrw9ew	104	8	focus	focus	VBP
cord-323756-atnrw9ew	104	9	on	on	IN
cord-323756-atnrw9ew	104	10	coronavirus	coronavirus	NN
cord-323756-atnrw9ew	104	11	infection	infection	NN
cord-323756-atnrw9ew	104	12	,	,	,
cord-323756-atnrw9ew	104	13	did	do	VBD
cord-323756-atnrw9ew	104	14	not	not	RB
cord-323756-atnrw9ew	104	15	elucidate	elucidate	VB
cord-323756-atnrw9ew	104	16	whether	whether	IN
cord-323756-atnrw9ew	104	17	the	the	DT
cord-323756-atnrw9ew	104	18	absence	absence	NN
cord-323756-atnrw9ew	104	19	of	of	IN
cord-323756-atnrw9ew	104	20	methylation	methylation	NN
cord-323756-atnrw9ew	104	21	was	be	VBD
cord-323756-atnrw9ew	104	22	directly	directly	RB
cord-323756-atnrw9ew	104	23	recognized	recognize	VBN
cord-323756-atnrw9ew	104	24	by	by	IN
cord-323756-atnrw9ew	104	25	MDA5	MDA5	NNP
cord-323756-atnrw9ew	104	26	or	or	CC
cord-323756-atnrw9ew	104	27	via	via	IN
cord-323756-atnrw9ew	104	28	another	another	DT
cord-323756-atnrw9ew	104	29	intermediate	intermediate	JJ
cord-323756-atnrw9ew	104	30	(	(	-LRB-
cord-323756-atnrw9ew	104	31	57	57	CD
cord-323756-atnrw9ew	104	32	)	)	-RRB-
cord-323756-atnrw9ew	104	33	.	.	.
cord-323756-atnrw9ew	105	1	After	after	IN
cord-323756-atnrw9ew	105	2	binding	bind	VBG
cord-323756-atnrw9ew	105	3	to	to	IN
cord-323756-atnrw9ew	105	4	their	-PRON-	PRP$
cord-323756-atnrw9ew	105	5	specific	specific	JJ
cord-323756-atnrw9ew	105	6	ligands	ligand	NNS
cord-323756-atnrw9ew	105	7	,	,	,
cord-323756-atnrw9ew	105	8	both	both	CC
cord-323756-atnrw9ew	105	9	RIG	rig	NN
cord-323756-atnrw9ew	105	10	-	-	:
cord-323756-atnrw9ew	105	11	I	I	NNP
cord-323756-atnrw9ew	105	12	and	and	CC
cord-323756-atnrw9ew	105	13	MDA5	MDA5	NNP
cord-323756-atnrw9ew	105	14	activate	activate	VBP
cord-323756-atnrw9ew	105	15	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	105	16	to	to	TO
cord-323756-atnrw9ew	105	17	trigger	trigger	VB
cord-323756-atnrw9ew	105	18	a	a	DT
cord-323756-atnrw9ew	105	19	common	common	JJ
cord-323756-atnrw9ew	105	20	signaling	signal	VBG
cord-323756-atnrw9ew	105	21	pathway	pathway	NN
cord-323756-atnrw9ew	105	22	.	.	.
cord-323756-atnrw9ew	106	1	The	the	DT
cord-323756-atnrw9ew	106	2	majority	majority	NN
cord-323756-atnrw9ew	106	3	of	of	IN
cord-323756-atnrw9ew	106	4	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	106	5	is	be	VBZ
cord-323756-atnrw9ew	106	6	localized	localize	VBN
cord-323756-atnrw9ew	106	7	on	on	IN
cord-323756-atnrw9ew	106	8	the	the	DT
cord-323756-atnrw9ew	106	9	mitochondrial	mitochondrial	JJ
cord-323756-atnrw9ew	106	10	membrane	membrane	NN
cord-323756-atnrw9ew	106	11	and	and	CC
cord-323756-atnrw9ew	106	12	its	-PRON-	PRP$
cord-323756-atnrw9ew	106	13	engagement	engagement	NN
cord-323756-atnrw9ew	106	14	by	by	IN
cord-323756-atnrw9ew	106	15	RLRs	rlr	NNS
cord-323756-atnrw9ew	106	16	causes	cause	VBZ
cord-323756-atnrw9ew	106	17	a	a	DT
cord-323756-atnrw9ew	106	18	conformational	conformational	JJ
cord-323756-atnrw9ew	106	19	change	change	NN
cord-323756-atnrw9ew	106	20	that	that	WDT
cord-323756-atnrw9ew	106	21	propagates	propagate	VBZ
cord-323756-atnrw9ew	106	22	to	to	IN
cord-323756-atnrw9ew	106	23	adjacent	adjacent	JJ
cord-323756-atnrw9ew	106	24	un	un	NNP
cord-323756-atnrw9ew	106	25	-	-	HYPH
cord-323756-atnrw9ew	106	26	activated	activate	VBN
cord-323756-atnrw9ew	106	27	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	106	28	in	in	IN
cord-323756-atnrw9ew	106	29	a	a	DT
cord-323756-atnrw9ew	106	30	prion	prion	NN
cord-323756-atnrw9ew	106	31	-	-	HYPH
cord-323756-atnrw9ew	106	32	like	like	JJ
cord-323756-atnrw9ew	106	33	behavior	behavior	NN
cord-323756-atnrw9ew	106	34	(	(	-LRB-
cord-323756-atnrw9ew	106	35	58	58	CD
cord-323756-atnrw9ew	106	36	)	)	-RRB-
cord-323756-atnrw9ew	106	37	.	.	.
cord-323756-atnrw9ew	107	1	The	the	DT
cord-323756-atnrw9ew	107	2	formation	formation	NN
cord-323756-atnrw9ew	107	3	of	of	IN
cord-323756-atnrw9ew	107	4	these	these	DT
cord-323756-atnrw9ew	107	5	very	very	RB
cord-323756-atnrw9ew	107	6	large	large	JJ
cord-323756-atnrw9ew	107	7	MAVS	MAVS	NNP
cord-323756-atnrw9ew	107	8	aggregates	aggregate	VBZ
cord-323756-atnrw9ew	107	9	results	result	VBZ
cord-323756-atnrw9ew	107	10	in	in	IN
cord-323756-atnrw9ew	107	11	a	a	DT
cord-323756-atnrw9ew	107	12	largescale	largescale	JJ
cord-323756-atnrw9ew	107	13	amplification	amplification	NN
cord-323756-atnrw9ew	107	14	of	of	IN
cord-323756-atnrw9ew	107	15	the	the	DT
cord-323756-atnrw9ew	107	16	signaling	signal	VBG
cord-323756-atnrw9ew	107	17	cascade	cascade	NN
cord-323756-atnrw9ew	107	18	.	.	.
cord-323756-atnrw9ew	108	1	This	this	DT
cord-323756-atnrw9ew	108	2	cascade	cascade	NN
cord-323756-atnrw9ew	108	3	involves	involve	VBZ
cord-323756-atnrw9ew	108	4	the	the	DT
cord-323756-atnrw9ew	108	5	recruitment	recruitment	NN
cord-323756-atnrw9ew	108	6	of	of	IN
cord-323756-atnrw9ew	108	7	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	108	8	adaptor	adaptor	NN
cord-323756-atnrw9ew	108	9	molecules	molecule	NNS
cord-323756-atnrw9ew	108	10	,	,	,
cord-323756-atnrw9ew	108	11	followed	follow	VBN
cord-323756-atnrw9ew	108	12	by	by	IN
cord-323756-atnrw9ew	108	13	the	the	DT
cord-323756-atnrw9ew	108	14	activation	activation	NN
cord-323756-atnrw9ew	108	15	of	of	IN
cord-323756-atnrw9ew	108	16	the	the	DT
cord-323756-atnrw9ew	108	17	canonical	canonical	JJ
cord-323756-atnrw9ew	108	18	IKKs	ikk	NNS
cord-323756-atnrw9ew	108	19	,	,	,
cord-323756-atnrw9ew	108	20	IKK	IKK	NNP
cord-323756-atnrw9ew	108	21	-	-	HYPH
cord-323756-atnrw9ew	108	22	α	α	NNP
cord-323756-atnrw9ew	108	23	,	,	,
cord-323756-atnrw9ew	108	24	IKK	IKK	NNP
cord-323756-atnrw9ew	108	25	-	-	HYPH
cord-323756-atnrw9ew	108	26	β	β	NNP
cord-323756-atnrw9ew	108	27	,	,	,
cord-323756-atnrw9ew	108	28	and	and	CC
cord-323756-atnrw9ew	108	29	IKK	IKK	NNP
cord-323756-atnrw9ew	108	30	-	-	HYPH
cord-323756-atnrw9ew	108	31	γ	γ	NNP
cord-323756-atnrw9ew	108	32	,	,	,
cord-323756-atnrw9ew	108	33	the	the	DT
cord-323756-atnrw9ew	108	34	MAPK	MAPK	NNP
cord-323756-atnrw9ew	108	35	and	and	CC
cord-323756-atnrw9ew	108	36	the	the	DT
cord-323756-atnrw9ew	108	37	non	non	JJ
cord-323756-atnrw9ew	108	38	-	-	JJ
cord-323756-atnrw9ew	108	39	canonical	canonical	JJ
cord-323756-atnrw9ew	108	40	IKK	IKK	NNP
cord-323756-atnrw9ew	108	41	-	-	HYPH
cord-323756-atnrw9ew	108	42	related	relate	VBN
cord-323756-atnrw9ew	108	43	kinase	kinase	NN
cord-323756-atnrw9ew	108	44	,	,	,
cord-323756-atnrw9ew	108	45	TBK1	TBK1	NNP
cord-323756-atnrw9ew	108	46	and	and	CC
cord-323756-atnrw9ew	108	47	IKKi	IKKi	NNP
cord-323756-atnrw9ew	108	48	/	/	SYM
cord-323756-atnrw9ew	108	49	ε	ε	NN
cord-323756-atnrw9ew	108	50	.	.	.
cord-323756-atnrw9ew	109	1	Ultimately	ultimately	RB
cord-323756-atnrw9ew	109	2	,	,	,
cord-323756-atnrw9ew	109	3	specific	specific	JJ
cord-323756-atnrw9ew	109	4	transcription	transcription	NN
cord-323756-atnrw9ew	109	5	factors	factor	NNS
cord-323756-atnrw9ew	109	6	,	,	,
cord-323756-atnrw9ew	109	7	such	such	JJ
cord-323756-atnrw9ew	109	8	as	as	IN
cord-323756-atnrw9ew	109	9	IRF3	IRF3	NNP
cord-323756-atnrw9ew	109	10	,	,	,
cord-323756-atnrw9ew	109	11	NF	NF	NNP
cord-323756-atnrw9ew	109	12	-	-	HYPH
cord-323756-atnrw9ew	109	13	κB	κB	NNP
cord-323756-atnrw9ew	109	14	,	,	,
cord-323756-atnrw9ew	109	15	and	and	CC
cord-323756-atnrw9ew	109	16	depending	depend	VBG
cord-323756-atnrw9ew	109	17	on	on	IN
cord-323756-atnrw9ew	109	18	the	the	DT
cord-323756-atnrw9ew	109	19	cell	cell	NN
cord-323756-atnrw9ew	109	20	type	type	NN
cord-323756-atnrw9ew	109	21	IRF5	IRF5	NNP
cord-323756-atnrw9ew	109	22	and	and	CC
cord-323756-atnrw9ew	109	23	IRF7	IRF7	NNP
cord-323756-atnrw9ew	109	24	,	,	,
cord-323756-atnrw9ew	109	25	are	be	VBP
cord-323756-atnrw9ew	109	26	translocated	translocate	VBN
cord-323756-atnrw9ew	109	27	to	to	IN
cord-323756-atnrw9ew	109	28	the	the	DT
cord-323756-atnrw9ew	109	29	nucleus	nucleus	NN
cord-323756-atnrw9ew	109	30	where	where	WRB
cord-323756-atnrw9ew	109	31	they	-PRON-	PRP
cord-323756-atnrw9ew	109	32	promote	promote	VBP
cord-323756-atnrw9ew	109	33	the	the	DT
cord-323756-atnrw9ew	109	34	expression	expression	NN
cord-323756-atnrw9ew	109	35	of	of	IN
cord-323756-atnrw9ew	109	36	IFN	IFN	NNP
cord-323756-atnrw9ew	109	37	-	-	HYPH
cord-323756-atnrw9ew	109	38	I	-PRON-	PRP
cord-323756-atnrw9ew	109	39	genes	gene	NNS
cord-323756-atnrw9ew	109	40	and	and	CC
cord-323756-atnrw9ew	109	41	pro	pro	JJ
cord-323756-atnrw9ew	109	42	-	-	JJ
cord-323756-atnrw9ew	109	43	inflammatory	inflammatory	JJ
cord-323756-atnrw9ew	109	44	cytokines	cytokine	NNS
cord-323756-atnrw9ew	109	45	[	[	-LRB-
cord-323756-atnrw9ew	109	46	reviewed	review	VBN
cord-323756-atnrw9ew	109	47	in	in	IN
cord-323756-atnrw9ew	109	48	Ref	Ref	NNP
cord-323756-atnrw9ew	109	49	.	.	.
cord-323756-atnrw9ew	110	1	(	(	-LRB-
cord-323756-atnrw9ew	110	2	59	59	CD
cord-323756-atnrw9ew	110	3	)	)	-RRB-
cord-323756-atnrw9ew	110	4	]	]	-RRB-
cord-323756-atnrw9ew	110	5	.	.	.
cord-323756-atnrw9ew	111	1	Finally	finally	RB
cord-323756-atnrw9ew	111	2	,	,	,
cord-323756-atnrw9ew	111	3	MAVS	MAVS	NNP
cord-323756-atnrw9ew	111	4	has	have	VBZ
cord-323756-atnrw9ew	111	5	been	be	VBN
cord-323756-atnrw9ew	111	6	recently	recently	RB
cord-323756-atnrw9ew	111	7	shown	show	VBN
cord-323756-atnrw9ew	111	8	to	to	TO
cord-323756-atnrw9ew	111	9	interact	interact	VB
cord-323756-atnrw9ew	111	10	with	with	IN
cord-323756-atnrw9ew	111	11	NODlike	nodlike	NN
cord-323756-atnrw9ew	111	12	receptor	receptor	NN
cord-323756-atnrw9ew	111	13	family	family	NN
cord-323756-atnrw9ew	111	14	,	,	,
cord-323756-atnrw9ew	111	15	pyrin	pyrin	NNP
cord-323756-atnrw9ew	111	16	domain	domain	NN
cord-323756-atnrw9ew	111	17	containing	contain	VBG
cord-323756-atnrw9ew	111	18	3	3	CD
cord-323756-atnrw9ew	111	19	(	(	-LRB-
cord-323756-atnrw9ew	111	20	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	111	21	)	)	-RRB-
cord-323756-atnrw9ew	111	22	and	and	CC
cord-323756-atnrw9ew	111	23	promote	promote	VB
cord-323756-atnrw9ew	111	24	its	-PRON-	PRP$
cord-323756-atnrw9ew	111	25	recruitment	recruitment	NN
cord-323756-atnrw9ew	111	26	to	to	IN
cord-323756-atnrw9ew	111	27	the	the	DT
cord-323756-atnrw9ew	111	28	mitochondria	mitochondrion	NNS
cord-323756-atnrw9ew	111	29	.	.	.
cord-323756-atnrw9ew	112	1	The	the	DT
cord-323756-atnrw9ew	112	2	authors	author	NNS
cord-323756-atnrw9ew	112	3	emphasize	emphasize	VBP
cord-323756-atnrw9ew	112	4	the	the	DT
cord-323756-atnrw9ew	112	5	central	central	JJ
cord-323756-atnrw9ew	112	6	role	role	NN
cord-323756-atnrw9ew	112	7	of	of	IN
cord-323756-atnrw9ew	112	8	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	112	9	in	in	IN
cord-323756-atnrw9ew	112	10	innate	innate	JJ
cord-323756-atnrw9ew	112	11	immune	immune	JJ
cord-323756-atnrw9ew	112	12	signaling	signal	VBG
cord-323756-atnrw9ew	112	13	events	event	NNS
cord-323756-atnrw9ew	112	14	by	by	IN
cord-323756-atnrw9ew	112	15	showing	show	VBG
cord-323756-atnrw9ew	112	16	its	-PRON-	PRP$
cord-323756-atnrw9ew	112	17	importance	importance	NN
cord-323756-atnrw9ew	112	18	in	in	IN
cord-323756-atnrw9ew	112	19	the	the	DT
cord-323756-atnrw9ew	112	20	functioning	functioning	NN
cord-323756-atnrw9ew	112	21	of	of	IN
cord-323756-atnrw9ew	112	22	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	112	23	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	112	24	and	and	CC
cord-323756-atnrw9ew	112	25	the	the	DT
cord-323756-atnrw9ew	112	26	production	production	NN
cord-323756-atnrw9ew	112	27	of	of	IN
cord-323756-atnrw9ew	112	28	IL-1β	IL-1β	NNP
cord-323756-atnrw9ew	112	29	(	(	-LRB-
cord-323756-atnrw9ew	112	30	60	60	CD
cord-323756-atnrw9ew	112	31	)	)	-RRB-
cord-323756-atnrw9ew	112	32	.	.	.
cord-323756-atnrw9ew	113	1	Of	of	IN
cord-323756-atnrw9ew	113	2	note	note	NN
cord-323756-atnrw9ew	113	3	,	,	,
cord-323756-atnrw9ew	113	4	MAVS	MAVS	NNP
cord-323756-atnrw9ew	113	5	independent	independent	JJ
cord-323756-atnrw9ew	113	6	activation	activation	NN
cord-323756-atnrw9ew	113	7	of	of	IN
cord-323756-atnrw9ew	113	8	the	the	DT
cord-323756-atnrw9ew	113	9	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	113	10	inflammasome	inflammasome	NN
cord-323756-atnrw9ew	113	11	by	by	IN
cord-323756-atnrw9ew	113	12	RIG	rig	NN
cord-323756-atnrw9ew	113	13	-	-	:
cord-323756-atnrw9ew	113	14	I	-PRON-	PRP
cord-323756-atnrw9ew	113	15	has	have	VBZ
cord-323756-atnrw9ew	113	16	also	also	RB
cord-323756-atnrw9ew	113	17	been	be	VBN
cord-323756-atnrw9ew	113	18	reported	report	VBN
cord-323756-atnrw9ew	113	19	(	(	-LRB-
cord-323756-atnrw9ew	113	20	61	61	CD
cord-323756-atnrw9ew	113	21	,	,	,
cord-323756-atnrw9ew	113	22	62	62	CD
cord-323756-atnrw9ew	113	23	)	)	-RRB-
cord-323756-atnrw9ew	113	24	.	.	.
cord-323756-atnrw9ew	114	1	The	the	DT
cord-323756-atnrw9ew	114	2	third	third	JJ
cord-323756-atnrw9ew	114	3	member	member	NN
cord-323756-atnrw9ew	114	4	of	of	IN
cord-323756-atnrw9ew	114	5	RLRs	rlr	NNS
cord-323756-atnrw9ew	114	6	,	,	,
cord-323756-atnrw9ew	114	7	LGP2	LGP2	NNP
cord-323756-atnrw9ew	114	8	,	,	,
cord-323756-atnrw9ew	114	9	is	be	VBZ
cord-323756-atnrw9ew	114	10	able	able	JJ
cord-323756-atnrw9ew	114	11	to	to	TO
cord-323756-atnrw9ew	114	12	bind	bind	VB
cord-323756-atnrw9ew	114	13	dsRNA	dsrna	JJ
cord-323756-atnrw9ew	114	14	(	(	-LRB-
cord-323756-atnrw9ew	114	15	63	63	CD
cord-323756-atnrw9ew	114	16	,	,	,
cord-323756-atnrw9ew	114	17	64	64	CD
cord-323756-atnrw9ew	114	18	)	)	-RRB-
cord-323756-atnrw9ew	114	19	,	,	,
cord-323756-atnrw9ew	114	20	however	however	RB
cord-323756-atnrw9ew	114	21	,	,	,
cord-323756-atnrw9ew	114	22	its	-PRON-	PRP$
cord-323756-atnrw9ew	114	23	role	role	NN
cord-323756-atnrw9ew	114	24	in	in	IN
cord-323756-atnrw9ew	114	25	immune	immune	JJ
cord-323756-atnrw9ew	114	26	activation	activation	NN
cord-323756-atnrw9ew	114	27	is	be	VBZ
cord-323756-atnrw9ew	114	28	poorly	poorly	RB
cord-323756-atnrw9ew	114	29	understood	understand	VBN
cord-323756-atnrw9ew	114	30	.	.	.
cord-323756-atnrw9ew	115	1	LGP2	LGP2	NNP
cord-323756-atnrw9ew	115	2	was	be	VBD
cord-323756-atnrw9ew	115	3	proposed	propose	VBN
cord-323756-atnrw9ew	115	4	to	to	TO
cord-323756-atnrw9ew	115	5	be	be	VB
cord-323756-atnrw9ew	115	6	a	a	DT
cord-323756-atnrw9ew	115	7	modulator	modulator	NN
cord-323756-atnrw9ew	115	8	of	of	IN
cord-323756-atnrw9ew	115	9	RLR	RLR	NNP
cord-323756-atnrw9ew	115	10	signaling	signaling	NN
cord-323756-atnrw9ew	115	11	.	.	.
cord-323756-atnrw9ew	116	1	Studies	study	NNS
cord-323756-atnrw9ew	116	2	showed	show	VBD
cord-323756-atnrw9ew	116	3	that	that	IN
cord-323756-atnrw9ew	116	4	LGP2	LGP2	NNP
cord-323756-atnrw9ew	116	5	was	be	VBD
cord-323756-atnrw9ew	116	6	required	require	VBN
cord-323756-atnrw9ew	116	7	for	for	IN
cord-323756-atnrw9ew	116	8	RIG	rig	NN
cord-323756-atnrw9ew	116	9	-	-	:
cord-323756-atnrw9ew	116	10	I	I	NNP
cord-323756-atnrw9ew	116	11	and	and	CC
cord-323756-atnrw9ew	116	12	MDA5	mda5	JJ
cord-323756-atnrw9ew	116	13	activity	activity	NN
cord-323756-atnrw9ew	116	14	,	,	,
cord-323756-atnrw9ew	116	15	in	in	IN
cord-323756-atnrw9ew	116	16	particular	particular	JJ
cord-323756-atnrw9ew	116	17	during	during	IN
cord-323756-atnrw9ew	116	18	picornaviral	picornaviral	JJ
cord-323756-atnrw9ew	116	19	infection	infection	NN
cord-323756-atnrw9ew	116	20	(	(	-LRB-
cord-323756-atnrw9ew	116	21	65	65	CD
cord-323756-atnrw9ew	116	22	)	)	-RRB-
cord-323756-atnrw9ew	117	1	(	(	-LRB-
cord-323756-atnrw9ew	117	2	66	66	CD
cord-323756-atnrw9ew	117	3	)	)	-RRB-
cord-323756-atnrw9ew	118	1	(	(	-LRB-
cord-323756-atnrw9ew	118	2	67	67	CD
cord-323756-atnrw9ew	118	3	)	)	-RRB-
cord-323756-atnrw9ew	118	4	.	.	.
cord-323756-atnrw9ew	119	1	Another	another	DT
cord-323756-atnrw9ew	119	2	work	work	NN
cord-323756-atnrw9ew	119	3	proposed	propose	VBD
cord-323756-atnrw9ew	119	4	that	that	IN
cord-323756-atnrw9ew	119	5	LGP2	LGP2	NNP
cord-323756-atnrw9ew	119	6	would	would	MD
cord-323756-atnrw9ew	119	7	inhibit	inhibit	VB
cord-323756-atnrw9ew	119	8	RIG	rig	NN
cord-323756-atnrw9ew	119	9	-	-	:
cord-323756-atnrw9ew	119	10	I	-PRON-	PRP
cord-323756-atnrw9ew	119	11	through	through	IN
cord-323756-atnrw9ew	119	12	competition	competition	NN
cord-323756-atnrw9ew	119	13	with	with	IN
cord-323756-atnrw9ew	119	14	its	-PRON-	PRP$
cord-323756-atnrw9ew	119	15	ligand	ligand	NN
cord-323756-atnrw9ew	119	16	(	(	-LRB-
cord-323756-atnrw9ew	119	17	64	64	CD
cord-323756-atnrw9ew	119	18	)	)	-RRB-
cord-323756-atnrw9ew	119	19	.	.	.
cord-323756-atnrw9ew	120	1	It	-PRON-	PRP
cord-323756-atnrw9ew	120	2	is	be	VBZ
cord-323756-atnrw9ew	120	3	however	however	RB
cord-323756-atnrw9ew	120	4	unclear	unclear	JJ
cord-323756-atnrw9ew	120	5	whether	whether	IN
cord-323756-atnrw9ew	120	6	LGP2	LGP2	NNP
cord-323756-atnrw9ew	120	7	binds	bind	VBZ
cord-323756-atnrw9ew	120	8	microbial	microbial	JJ
cord-323756-atnrw9ew	120	9	RNA	RNA	NNP
cord-323756-atnrw9ew	120	10	in	in	IN
cord-323756-atnrw9ew	120	11	an	an	DT
cord-323756-atnrw9ew	120	12	infectious	infectious	JJ
cord-323756-atnrw9ew	120	13	context	context	NN
cord-323756-atnrw9ew	120	14	,	,	,
cord-323756-atnrw9ew	120	15	and	and	CC
cord-323756-atnrw9ew	120	16	what	what	WDT
cord-323756-atnrw9ew	120	17	specific	specific	JJ
cord-323756-atnrw9ew	120	18	features	feature	NNS
cord-323756-atnrw9ew	120	19	of	of	IN
cord-323756-atnrw9ew	120	20	the	the	DT
cord-323756-atnrw9ew	120	21	RNA	RNA	NNP
cord-323756-atnrw9ew	120	22	it	-PRON-	PRP
cord-323756-atnrw9ew	120	23	would	would	MD
cord-323756-atnrw9ew	120	24	recognize	recognize	VB
cord-323756-atnrw9ew	120	25	.	.	.
cord-323756-atnrw9ew	121	1	Further	further	JJ
cord-323756-atnrw9ew	121	2	studies	study	NNS
cord-323756-atnrw9ew	121	3	will	will	MD
cord-323756-atnrw9ew	121	4	be	be	VB
cord-323756-atnrw9ew	121	5	required	require	VBN
cord-323756-atnrw9ew	121	6	to	to	TO
cord-323756-atnrw9ew	121	7	clarify	clarify	VB
cord-323756-atnrw9ew	121	8	the	the	DT
cord-323756-atnrw9ew	121	9	precise	precise	JJ
cord-323756-atnrw9ew	121	10	role	role	NN
cord-323756-atnrw9ew	121	11	of	of	IN
cord-323756-atnrw9ew	121	12	LGP2	LGP2	NNP
cord-323756-atnrw9ew	121	13	.	.	.
cord-323756-atnrw9ew	122	1	Apart	apart	RB
cord-323756-atnrw9ew	122	2	from	from	IN
cord-323756-atnrw9ew	122	3	RLR	RLR	NNP
cord-323756-atnrw9ew	122	4	,	,	,
cord-323756-atnrw9ew	122	5	several	several	JJ
cord-323756-atnrw9ew	122	6	recent	recent	JJ
cord-323756-atnrw9ew	122	7	studies	study	NNS
cord-323756-atnrw9ew	122	8	have	have	VBP
cord-323756-atnrw9ew	122	9	highlighted	highlight	VBN
cord-323756-atnrw9ew	122	10	the	the	DT
cord-323756-atnrw9ew	122	11	importance	importance	NN
cord-323756-atnrw9ew	122	12	of	of	IN
cord-323756-atnrw9ew	122	13	other	other	JJ
cord-323756-atnrw9ew	122	14	DExD	DExD	NNS
cord-323756-atnrw9ew	122	15	/	/	SYM
cord-323756-atnrw9ew	122	16	H	h	NN
cord-323756-atnrw9ew	122	17	-	-	HYPH
cord-323756-atnrw9ew	122	18	box	box	NN
cord-323756-atnrw9ew	122	19	helicases	helicase	NNS
cord-323756-atnrw9ew	122	20	in	in	IN
cord-323756-atnrw9ew	122	21	microbial	microbial	JJ
cord-323756-atnrw9ew	122	22	RNA	RNA	NNP
cord-323756-atnrw9ew	122	23	sensing	sensing	NN
cord-323756-atnrw9ew	122	24	.	.	.
cord-323756-atnrw9ew	123	1	RNA	RNA	NNP
cord-323756-atnrw9ew	123	2	helicases	helicase	NNS
cord-323756-atnrw9ew	123	3	of	of	IN
cord-323756-atnrw9ew	123	4	the	the	DT
cord-323756-atnrw9ew	123	5	DEAD	DEAD	NNP
cord-323756-atnrw9ew	123	6	box	box	NN
cord-323756-atnrw9ew	123	7	family	family	NN
cord-323756-atnrw9ew	123	8	are	be	VBP
cord-323756-atnrw9ew	123	9	involved	involve	VBN
cord-323756-atnrw9ew	123	10	in	in	IN
cord-323756-atnrw9ew	123	11	various	various	JJ
cord-323756-atnrw9ew	123	12	different	different	JJ
cord-323756-atnrw9ew	123	13	steps	step	NNS
cord-323756-atnrw9ew	123	14	of	of	IN
cord-323756-atnrw9ew	123	15	RNA	RNA	NNP
cord-323756-atnrw9ew	123	16	metabolism	metabolism	NN
cord-323756-atnrw9ew	123	17	[	[	-LRB-
cord-323756-atnrw9ew	123	18	reviewed	review	VBN
cord-323756-atnrw9ew	123	19	in	in	IN
cord-323756-atnrw9ew	123	20	Ref	Ref	NNP
cord-323756-atnrw9ew	123	21	.	.	.
cord-323756-atnrw9ew	124	1	(	(	-LRB-
cord-323756-atnrw9ew	124	2	68	68	CD
cord-323756-atnrw9ew	124	3	)	)	-RRB-
cord-323756-atnrw9ew	124	4	]	]	-RRB-
cord-323756-atnrw9ew	124	5	.	.	.
cord-323756-atnrw9ew	125	1	They	-PRON-	PRP
cord-323756-atnrw9ew	125	2	share	share	VBP
cord-323756-atnrw9ew	125	3	eight	eight	CD
cord-323756-atnrw9ew	125	4	conserved	conserved	JJ
cord-323756-atnrw9ew	125	5	motifs	motif	NNS
cord-323756-atnrw9ew	125	6	that	that	WDT
cord-323756-atnrw9ew	125	7	are	be	VBP
cord-323756-atnrw9ew	125	8	involved	involve	VBN
cord-323756-atnrw9ew	125	9	in	in	IN
cord-323756-atnrw9ew	125	10	ATP	ATP	NNP
cord-323756-atnrw9ew	125	11	binding	binding	NN
cord-323756-atnrw9ew	125	12	,	,	,
cord-323756-atnrw9ew	125	13	ATP	ATP	NNP
cord-323756-atnrw9ew	125	14	hydrolysis	hydrolysis	NN
cord-323756-atnrw9ew	125	15	,	,	,
cord-323756-atnrw9ew	125	16	nucleic	nucleic	JJ
cord-323756-atnrw9ew	125	17	acid	acid	NN
cord-323756-atnrw9ew	125	18	binding	binding	NN
cord-323756-atnrw9ew	125	19	,	,	,
cord-323756-atnrw9ew	125	20	and	and	CC
cord-323756-atnrw9ew	125	21	RNA	RNA	NNP
cord-323756-atnrw9ew	125	22	unwinding	unwinding	NN
cord-323756-atnrw9ew	125	23	activity	activity	NN
cord-323756-atnrw9ew	125	24	.	.	.
cord-323756-atnrw9ew	126	1	Additionally	additionally	RB
cord-323756-atnrw9ew	126	2	,	,	,
cord-323756-atnrw9ew	126	3	most	most	JJS
cord-323756-atnrw9ew	126	4	DExD	dexd	JJ
cord-323756-atnrw9ew	126	5	/	/	SYM
cord-323756-atnrw9ew	126	6	H	h	NN
cord-323756-atnrw9ew	126	7	-	-	HYPH
cord-323756-atnrw9ew	126	8	box	box	NN
cord-323756-atnrw9ew	126	9	helicases	helicase	NNS
cord-323756-atnrw9ew	126	10	contain	contain	VBP
cord-323756-atnrw9ew	126	11	auxiliary	auxiliary	JJ
cord-323756-atnrw9ew	126	12	Nand	Nand	NNP
cord-323756-atnrw9ew	126	13	C	C	NNP
cord-323756-atnrw9ew	126	14	-	-	HYPH
cord-323756-atnrw9ew	126	15	terminal	terminal	NN
cord-323756-atnrw9ew	126	16	domains	domain	NNS
cord-323756-atnrw9ew	126	17	that	that	WDT
cord-323756-atnrw9ew	126	18	confer	confer	VBP
cord-323756-atnrw9ew	126	19	on	on	IN
cord-323756-atnrw9ew	126	20	them	-PRON-	PRP
cord-323756-atnrw9ew	126	21	functional	functional	JJ
cord-323756-atnrw9ew	126	22	specificities	specificity	NNS
cord-323756-atnrw9ew	126	23	,	,	,
cord-323756-atnrw9ew	126	24	such	such	JJ
cord-323756-atnrw9ew	126	25	as	as	IN
cord-323756-atnrw9ew	126	26	an	an	DT
cord-323756-atnrw9ew	126	27	ability	ability	NN
cord-323756-atnrw9ew	126	28	to	to	TO
cord-323756-atnrw9ew	126	29	induce	induce	VB
cord-323756-atnrw9ew	126	30	downstream	downstream	JJ
cord-323756-atnrw9ew	126	31	signaling	signaling	NN
cord-323756-atnrw9ew	126	32	or	or	CC
cord-323756-atnrw9ew	126	33	to	to	TO
cord-323756-atnrw9ew	126	34	bind	bind	VB
cord-323756-atnrw9ew	126	35	specific	specific	JJ
cord-323756-atnrw9ew	126	36	RNA	RNA	NNP
cord-323756-atnrw9ew	126	37	targets	target	NNS
cord-323756-atnrw9ew	126	38	(	(	-LRB-
cord-323756-atnrw9ew	126	39	69	69	CD
cord-323756-atnrw9ew	126	40	)	)	-RRB-
cord-323756-atnrw9ew	126	41	.	.	.
cord-323756-atnrw9ew	127	1	DDX3	DDX3	NNP
cord-323756-atnrw9ew	127	2	(	(	-LRB-
cord-323756-atnrw9ew	127	3	DDX3X	DDX3X	NNS
cord-323756-atnrw9ew	127	4	)	)	-RRB-
cord-323756-atnrw9ew	127	5	can	can	MD
cord-323756-atnrw9ew	127	6	bind	bind	VB
cord-323756-atnrw9ew	127	7	poly(I	poly(I	NNP
cord-323756-atnrw9ew	127	8	:	:	:
cord-323756-atnrw9ew	127	9	C	C	NNP
cord-323756-atnrw9ew	127	10	)	)	-RRB-
cord-323756-atnrw9ew	127	11	or	or	CC
cord-323756-atnrw9ew	127	12	vesicular	vesicular	JJ
cord-323756-atnrw9ew	127	13	stomatitis	stomatitis	NN
cord-323756-atnrw9ew	127	14	virus	virus	NN
cord-323756-atnrw9ew	127	15	(	(	-LRB-
cord-323756-atnrw9ew	127	16	VSV	VSV	NNP
cord-323756-atnrw9ew	127	17	)	)	-RRB-
cord-323756-atnrw9ew	127	18	RNA	RNA	NNP
cord-323756-atnrw9ew	128	1	and	and	CC
cord-323756-atnrw9ew	128	2	was	be	VBD
cord-323756-atnrw9ew	128	3	shown	show	VBN
cord-323756-atnrw9ew	128	4	to	to	TO
cord-323756-atnrw9ew	128	5	enhance	enhance	VB
cord-323756-atnrw9ew	128	6	the	the	DT
cord-323756-atnrw9ew	128	7	IFN	IFN	NNP
cord-323756-atnrw9ew	128	8	-	-	HYPH
cord-323756-atnrw9ew	128	9	I	-PRON-	PRP
cord-323756-atnrw9ew	128	10	response	response	NN
cord-323756-atnrw9ew	128	11	to	to	IN
cord-323756-atnrw9ew	128	12	VSV	VSV	NNP
cord-323756-atnrw9ew	128	13	infection	infection	NN
cord-323756-atnrw9ew	128	14	by	by	IN
cord-323756-atnrw9ew	128	15	interaction	interaction	NN
cord-323756-atnrw9ew	128	16	with	with	IN
cord-323756-atnrw9ew	128	17	the	the	DT
cord-323756-atnrw9ew	128	18	RLR	RLR	NNP
cord-323756-atnrw9ew	128	19	-	-	HYPH
cord-323756-atnrw9ew	128	20	MAVS	MAVS	NNP
cord-323756-atnrw9ew	128	21	complex	complex	JJ
cord-323756-atnrw9ew	128	22	.	.	.
cord-323756-atnrw9ew	129	1	Overexpression	overexpression	NN
cord-323756-atnrw9ew	129	2	assays	assay	NNS
cord-323756-atnrw9ew	129	3	suggest	suggest	VBP
cord-323756-atnrw9ew	129	4	that	that	IN
cord-323756-atnrw9ew	129	5	DDX3	DDX3	NNP
cord-323756-atnrw9ew	129	6	precipitates	precipitate	VBZ
cord-323756-atnrw9ew	129	7	with	with	IN
cord-323756-atnrw9ew	129	8	RIG	rig	NN
cord-323756-atnrw9ew	129	9	-	-	:
cord-323756-atnrw9ew	129	10	I	I	NNP
cord-323756-atnrw9ew	129	11	and	and	CC
cord-323756-atnrw9ew	129	12	MDA5	MDA5	NNP
cord-323756-atnrw9ew	129	13	(	(	-LRB-
cord-323756-atnrw9ew	129	14	70	70	CD
cord-323756-atnrw9ew	129	15	)	)	-RRB-
cord-323756-atnrw9ew	129	16	.	.	.
cord-323756-atnrw9ew	130	1	Since	since	IN
cord-323756-atnrw9ew	130	2	DDX3	DDX3	NNP
cord-323756-atnrw9ew	130	3	is	be	VBZ
cord-323756-atnrw9ew	130	4	easily	easily	RB
cord-323756-atnrw9ew	130	5	detected	detect	VBN
cord-323756-atnrw9ew	130	6	in	in	IN
cord-323756-atnrw9ew	130	7	resting	rest	VBG
cord-323756-atnrw9ew	130	8	cells	cell	NNS
cord-323756-atnrw9ew	130	9	,	,	,
cord-323756-atnrw9ew	130	10	the	the	DT
cord-323756-atnrw9ew	130	11	authors	author	NNS
cord-323756-atnrw9ew	130	12	propose	propose	VBP
cord-323756-atnrw9ew	130	13	a	a	DT
cord-323756-atnrw9ew	130	14	sentinel	sentinel	JJ
cord-323756-atnrw9ew	130	15	role	role	NN
cord-323756-atnrw9ew	130	16	for	for	IN
cord-323756-atnrw9ew	130	17	this	this	DT
cord-323756-atnrw9ew	130	18	helicase	helicase	NN
cord-323756-atnrw9ew	130	19	,	,	,
cord-323756-atnrw9ew	130	20	the	the	DT
cord-323756-atnrw9ew	130	21	activity	activity	NN
cord-323756-atnrw9ew	130	22	of	of	IN
cord-323756-atnrw9ew	130	23	which	which	WDT
cord-323756-atnrw9ew	130	24	would	would	MD
cord-323756-atnrw9ew	130	25	be	be	VB
cord-323756-atnrw9ew	130	26	required	require	VBN
cord-323756-atnrw9ew	130	27	during	during	IN
cord-323756-atnrw9ew	130	28	the	the	DT
cord-323756-atnrw9ew	130	29	initial	initial	JJ
cord-323756-atnrw9ew	130	30	steps	step	NNS
cord-323756-atnrw9ew	130	31	of	of	IN
cord-323756-atnrw9ew	130	32	viral	viral	JJ
cord-323756-atnrw9ew	130	33	infection	infection	NN
cord-323756-atnrw9ew	130	34	.	.	.
cord-323756-atnrw9ew	131	1	Another	another	DT
cord-323756-atnrw9ew	131	2	study	study	NN
cord-323756-atnrw9ew	131	3	showed	show	VBD
cord-323756-atnrw9ew	131	4	that	that	IN
cord-323756-atnrw9ew	131	5	upon	upon	IN
cord-323756-atnrw9ew	131	6	SeV	sev	NN
cord-323756-atnrw9ew	131	7	infection	infection	NN
cord-323756-atnrw9ew	131	8	,	,	,
cord-323756-atnrw9ew	131	9	DDX3	DDX3	NNP
cord-323756-atnrw9ew	131	10	interacts	interact	VBZ
cord-323756-atnrw9ew	131	11	with	with	IN
cord-323756-atnrw9ew	131	12	IKKε	IKKε	NNS
cord-323756-atnrw9ew	131	13	,	,	,
cord-323756-atnrw9ew	131	14	an	an	DT
cord-323756-atnrw9ew	131	15	essential	essential	JJ
cord-323756-atnrw9ew	131	16	component	component	NN
cord-323756-atnrw9ew	131	17	of	of	IN
cord-323756-atnrw9ew	131	18	the	the	DT
cord-323756-atnrw9ew	131	19	IRF3	IRF3	NNP
cord-323756-atnrw9ew	131	20	signaling	signal	VBG
cord-323756-atnrw9ew	131	21	pathway	pathway	NN
cord-323756-atnrw9ew	131	22	,	,	,
cord-323756-atnrw9ew	131	23	increasing	increase	VBG
cord-323756-atnrw9ew	131	24	the	the	DT
cord-323756-atnrw9ew	131	25	induction	induction	NN
cord-323756-atnrw9ew	131	26	of	of	IN
cord-323756-atnrw9ew	131	27	the	the	DT
cord-323756-atnrw9ew	131	28	IFN	IFN	NNP
cord-323756-atnrw9ew	131	29	-	-	HYPH
cord-323756-atnrw9ew	131	30	β	β	NNP
cord-323756-atnrw9ew	131	31	promoter	promoter	NN
cord-323756-atnrw9ew	131	32	(	(	-LRB-
cord-323756-atnrw9ew	131	33	71	71	CD
cord-323756-atnrw9ew	131	34	)	)	-RRB-
cord-323756-atnrw9ew	131	35	.	.	.
cord-323756-atnrw9ew	132	1	Moreover	moreover	RB
cord-323756-atnrw9ew	132	2	,	,	,
cord-323756-atnrw9ew	132	3	DDX3	DDX3	NNP
cord-323756-atnrw9ew	132	4	is	be	VBZ
cord-323756-atnrw9ew	132	5	targeted	target	VBN
cord-323756-atnrw9ew	132	6	by	by	IN
cord-323756-atnrw9ew	132	7	vaccinia	vaccinia	NN
cord-323756-atnrw9ew	132	8	virus	virus	NN
cord-323756-atnrw9ew	132	9	protein	protein	NN
cord-323756-atnrw9ew	132	10	K7	K7	NNP
cord-323756-atnrw9ew	132	11	(	(	-LRB-
cord-323756-atnrw9ew	132	12	71	71	CD
cord-323756-atnrw9ew	132	13	)	)	-RRB-
cord-323756-atnrw9ew	132	14	,	,	,
cord-323756-atnrw9ew	132	15	an	an	DT
cord-323756-atnrw9ew	132	16	inhibitor	inhibitor	NN
cord-323756-atnrw9ew	132	17	of	of	IN
cord-323756-atnrw9ew	132	18	IFN	IFN	NNP
cord-323756-atnrw9ew	132	19	-	-	HYPH
cord-323756-atnrw9ew	132	20	β	β	NNP
cord-323756-atnrw9ew	132	21	production	production	NN
cord-323756-atnrw9ew	132	22	,	,	,
cord-323756-atnrw9ew	132	23	and	and	CC
cord-323756-atnrw9ew	132	24	by	by	IN
cord-323756-atnrw9ew	132	25	HCV	HCV	NNP
cord-323756-atnrw9ew	132	26	core	core	NN
cord-323756-atnrw9ew	132	27	protein	protein	NN
cord-323756-atnrw9ew	132	28	,	,	,
cord-323756-atnrw9ew	132	29	which	which	WDT
cord-323756-atnrw9ew	132	30	can	can	MD
cord-323756-atnrw9ew	132	31	disrupt	disrupt	VB
cord-323756-atnrw9ew	132	32	its	-PRON-	PRP$
cord-323756-atnrw9ew	132	33	interaction	interaction	NN
cord-323756-atnrw9ew	132	34	with	with	IN
cord-323756-atnrw9ew	132	35	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	132	36	(	(	-LRB-
cord-323756-atnrw9ew	132	37	72	72	CD
cord-323756-atnrw9ew	132	38	)	)	-RRB-
cord-323756-atnrw9ew	132	39	.	.	.
cord-323756-atnrw9ew	133	1	These	these	DT
cord-323756-atnrw9ew	133	2	observations	observation	NNS
cord-323756-atnrw9ew	133	3	highlight	highlight	VBP
cord-323756-atnrw9ew	133	4	the	the	DT
cord-323756-atnrw9ew	133	5	importance	importance	NN
cord-323756-atnrw9ew	133	6	of	of	IN
cord-323756-atnrw9ew	133	7	DDX3	DDX3	NNP
cord-323756-atnrw9ew	133	8	in	in	IN
cord-323756-atnrw9ew	133	9	efficient	efficient	JJ
cord-323756-atnrw9ew	133	10	viral	viral	JJ
cord-323756-atnrw9ew	133	11	sensing	sensing	NN
cord-323756-atnrw9ew	133	12	.	.	.
cord-323756-atnrw9ew	134	1	Using	use	VBG
cord-323756-atnrw9ew	134	2	overexpression	overexpression	NN
cord-323756-atnrw9ew	134	3	and	and	CC
cord-323756-atnrw9ew	134	4	knock	knock	VB
cord-323756-atnrw9ew	134	5	-	-	HYPH
cord-323756-atnrw9ew	134	6	down	down	RP
cord-323756-atnrw9ew	134	7	experiments	experiment	NNS
cord-323756-atnrw9ew	134	8	,	,	,
cord-323756-atnrw9ew	134	9	DHX9	DHX9	NNP
cord-323756-atnrw9ew	134	10	was	be	VBD
cord-323756-atnrw9ew	134	11	shown	show	VBN
cord-323756-atnrw9ew	134	12	to	to	TO
cord-323756-atnrw9ew	134	13	be	be	VB
cord-323756-atnrw9ew	134	14	required	require	VBN
cord-323756-atnrw9ew	134	15	for	for	IN
cord-323756-atnrw9ew	134	16	the	the	DT
cord-323756-atnrw9ew	134	17	production	production	NN
cord-323756-atnrw9ew	134	18	of	of	IN
cord-323756-atnrw9ew	134	19	IFN	IFN	NNP
cord-323756-atnrw9ew	134	20	-	-	HYPH
cord-323756-atnrw9ew	134	21	I	I	NNP
cord-323756-atnrw9ew	134	22	and	and	CC
cord-323756-atnrw9ew	134	23	proinflammatory	proinflammatory	JJ
cord-323756-atnrw9ew	134	24	cytokines	cytokine	NNS
cord-323756-atnrw9ew	134	25	in	in	IN
cord-323756-atnrw9ew	134	26	response	response	NN
cord-323756-atnrw9ew	134	27	to	to	IN
cord-323756-atnrw9ew	134	28	poly(I	poly(I	NNS
cord-323756-atnrw9ew	134	29	:	:	:
cord-323756-atnrw9ew	134	30	C	C	NNP
cord-323756-atnrw9ew	134	31	)	)	-RRB-
cord-323756-atnrw9ew	134	32	,	,	,
cord-323756-atnrw9ew	134	33	influenza	influenza	NN
cord-323756-atnrw9ew	134	34	virus	virus	NN
cord-323756-atnrw9ew	134	35	,	,	,
cord-323756-atnrw9ew	134	36	and	and	CC
cord-323756-atnrw9ew	134	37	reovirus	reovirus	NNP
cord-323756-atnrw9ew	134	38	by	by	IN
cord-323756-atnrw9ew	134	39	a	a	DT
cord-323756-atnrw9ew	134	40	murine	murine	JJ
cord-323756-atnrw9ew	134	41	splenic	splenic	JJ
cord-323756-atnrw9ew	134	42	DC	DC	NNP
cord-323756-atnrw9ew	134	43	line	line	NN
cord-323756-atnrw9ew	134	44	and	and	CC
cord-323756-atnrw9ew	134	45	bone	bone	NN
cord-323756-atnrw9ew	134	46	-	-	HYPH
cord-323756-atnrw9ew	134	47	marrow	marrow	NN
cord-323756-atnrw9ew	134	48	derived	derive	VBN
cord-323756-atnrw9ew	134	49	DCs	DCs	NNP
cord-323756-atnrw9ew	134	50	.	.	.
cord-323756-atnrw9ew	135	1	DHX9	DHX9	NNP
cord-323756-atnrw9ew	135	2	can	can	MD
cord-323756-atnrw9ew	135	3	bind	bind	VB
cord-323756-atnrw9ew	135	4	dsRNA	dsrna	NN
cord-323756-atnrw9ew	135	5	via	via	IN
cord-323756-atnrw9ew	135	6	its	-PRON-	PRP$
cord-323756-atnrw9ew	135	7	dsRNA	dsrna	JJ
cord-323756-atnrw9ew	135	8	-	-	HYPH
cord-323756-atnrw9ew	135	9	binding	bind	VBG
cord-323756-atnrw9ew	135	10	motif	motif	NN
cord-323756-atnrw9ew	135	11	and	and	CC
cord-323756-atnrw9ew	135	12	interact	interact	VB
cord-323756-atnrw9ew	135	13	with	with	IN
cord-323756-atnrw9ew	135	14	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	135	15	through	through	IN
cord-323756-atnrw9ew	135	16	both	both	CC
cord-323756-atnrw9ew	135	17	its	-PRON-	PRP$
cord-323756-atnrw9ew	135	18	helicase	helicase	NN
cord-323756-atnrw9ew	135	19	C	c	NN
cord-323756-atnrw9ew	135	20	-	-	HYPH
cord-323756-atnrw9ew	135	21	terminal	terminal	NN
cord-323756-atnrw9ew	135	22	domain	domain	NN
cord-323756-atnrw9ew	135	23	and	and	CC
cord-323756-atnrw9ew	135	24	HA2-DUF	HA2-DUF	NNP
cord-323756-atnrw9ew	135	25	(	(	-LRB-
cord-323756-atnrw9ew	135	26	73	73	CD
cord-323756-atnrw9ew	135	27	)	)	-RRB-
cord-323756-atnrw9ew	135	28	.	.	.
cord-323756-atnrw9ew	136	1	Myeloid	Myeloid	NNP
cord-323756-atnrw9ew	136	2	DCs	dc	NNS
cord-323756-atnrw9ew	136	3	have	have	VBP
cord-323756-atnrw9ew	136	4	also	also	RB
cord-323756-atnrw9ew	136	5	been	be	VBN
cord-323756-atnrw9ew	136	6	shown	show	VBN
cord-323756-atnrw9ew	136	7	to	to	TO
cord-323756-atnrw9ew	136	8	express	express	VB
cord-323756-atnrw9ew	136	9	a	a	DT
cord-323756-atnrw9ew	136	10	complex	complex	NN
cord-323756-atnrw9ew	136	11	composed	compose	VBN
cord-323756-atnrw9ew	136	12	of	of	IN
cord-323756-atnrw9ew	136	13	DDX1	DDX1	NNP
cord-323756-atnrw9ew	136	14	,	,	,
cord-323756-atnrw9ew	136	15	DDX21	DDX21	NNP
cord-323756-atnrw9ew	136	16	,	,	,
cord-323756-atnrw9ew	136	17	and	and	CC
cord-323756-atnrw9ew	136	18	DHX36	DHX36	NNP
cord-323756-atnrw9ew	136	19	that	that	WDT
cord-323756-atnrw9ew	136	20	triggers	trigger	VBZ
cord-323756-atnrw9ew	136	21	an	an	DT
cord-323756-atnrw9ew	136	22	antiviral	antiviral	JJ
cord-323756-atnrw9ew	136	23	program	program	NN
cord-323756-atnrw9ew	136	24	in	in	IN
cord-323756-atnrw9ew	136	25	response	response	NN
cord-323756-atnrw9ew	136	26	to	to	IN
cord-323756-atnrw9ew	136	27	poly(I	poly(I	NNS
cord-323756-atnrw9ew	136	28	:	:	:
cord-323756-atnrw9ew	136	29	C	C	NNP
cord-323756-atnrw9ew	136	30	)	)	-RRB-
cord-323756-atnrw9ew	136	31	,	,	,
cord-323756-atnrw9ew	136	32	in	in	IN
cord-323756-atnrw9ew	136	33	a	a	DT
cord-323756-atnrw9ew	136	34	pathway	pathway	NN
cord-323756-atnrw9ew	136	35	dependent	dependent	JJ
cord-323756-atnrw9ew	136	36	of	of	IN
cord-323756-atnrw9ew	136	37	the	the	DT
cord-323756-atnrw9ew	136	38	adapter	adapter	NN
cord-323756-atnrw9ew	136	39	molecule	molecule	NN
cord-323756-atnrw9ew	136	40	TIR	TIR	NNP
cord-323756-atnrw9ew	136	41	-	-	HYPH
cord-323756-atnrw9ew	136	42	domain	domain	NN
cord-323756-atnrw9ew	136	43	containing	contain	VBG
cord-323756-atnrw9ew	136	44	adapter	adapter	NN
cord-323756-atnrw9ew	136	45	-	-	HYPH
cord-323756-atnrw9ew	136	46	inducing	induce	VBG
cord-323756-atnrw9ew	136	47	interferon	interferon	NN
cord-323756-atnrw9ew	136	48	-	-	HYPH
cord-323756-atnrw9ew	136	49	β	β	NN
cord-323756-atnrw9ew	136	50	(	(	-LRB-
cord-323756-atnrw9ew	136	51	TRIF	TRIF	NNP
cord-323756-atnrw9ew	136	52	)	)	-RRB-
cord-323756-atnrw9ew	136	53	.	.	.
cord-323756-atnrw9ew	137	1	DDX1	DDX1	NNP
cord-323756-atnrw9ew	137	2	binds	bind	VBZ
cord-323756-atnrw9ew	137	3	to	to	IN
cord-323756-atnrw9ew	137	4	poly(I	poly(i	NN
cord-323756-atnrw9ew	137	5	:	:	:
cord-323756-atnrw9ew	137	6	C	C	NNP
cord-323756-atnrw9ew	137	7	)	)	-RRB-
cord-323756-atnrw9ew	138	1	via	via	IN
cord-323756-atnrw9ew	138	2	its	-PRON-	PRP$
cord-323756-atnrw9ew	138	3	helicase	helicase	NN
cord-323756-atnrw9ew	138	4	A	a	DT
cord-323756-atnrw9ew	138	5	domain	domain	NN
cord-323756-atnrw9ew	138	6	,	,	,
cord-323756-atnrw9ew	138	7	while	while	IN
cord-323756-atnrw9ew	138	8	DHX36	DHX36	NNP
cord-323756-atnrw9ew	138	9	and	and	CC
cord-323756-atnrw9ew	138	10	DDX21	DDX21	NNP
cord-323756-atnrw9ew	138	11	bind	bind	VBP
cord-323756-atnrw9ew	138	12	the	the	DT
cord-323756-atnrw9ew	138	13	TIR	TIR	NNP
cord-323756-atnrw9ew	138	14	domain	domain	NN
cord-323756-atnrw9ew	138	15	of	of	IN
cord-323756-atnrw9ew	138	16	TRIF	TRIF	NNP
cord-323756-atnrw9ew	138	17	via	via	IN
cord-323756-atnrw9ew	138	18	their	-PRON-	PRP$
cord-323756-atnrw9ew	138	19	HA2-DUF	HA2-DUF	NNP
cord-323756-atnrw9ew	138	20	and	and	CC
cord-323756-atnrw9ew	138	21	PRK	PRK	NNP
cord-323756-atnrw9ew	138	22	domains	domain	NNS
cord-323756-atnrw9ew	138	23	,	,	,
cord-323756-atnrw9ew	138	24	respectively	respectively	RB
cord-323756-atnrw9ew	138	25	.	.	.
cord-323756-atnrw9ew	139	1	This	this	DT
cord-323756-atnrw9ew	139	2	complex	complex	NN
cord-323756-atnrw9ew	139	3	seems	seem	VBZ
cord-323756-atnrw9ew	139	4	to	to	TO
cord-323756-atnrw9ew	139	5	be	be	VB
cord-323756-atnrw9ew	139	6	required	require	VBN
cord-323756-atnrw9ew	139	7	for	for	IN
cord-323756-atnrw9ew	139	8	the	the	DT
cord-323756-atnrw9ew	139	9	innate	innate	JJ
cord-323756-atnrw9ew	139	10	response	response	NN
cord-323756-atnrw9ew	139	11	against	against	IN
cord-323756-atnrw9ew	139	12	influenza	influenza	NN
cord-323756-atnrw9ew	139	13	or	or	CC
cord-323756-atnrw9ew	139	14	reovirus	reovirus	NNP
cord-323756-atnrw9ew	139	15	infection	infection	NN
cord-323756-atnrw9ew	139	16	(	(	-LRB-
cord-323756-atnrw9ew	139	17	74	74	CD
cord-323756-atnrw9ew	139	18	)	)	-RRB-
cord-323756-atnrw9ew	139	19	.	.	.
cord-323756-atnrw9ew	140	1	Notably	notably	RB
cord-323756-atnrw9ew	140	2	,	,	,
cord-323756-atnrw9ew	140	3	a	a	DT
cord-323756-atnrw9ew	140	4	separate	separate	JJ
cord-323756-atnrw9ew	140	5	study	study	NN
cord-323756-atnrw9ew	140	6	also	also	RB
cord-323756-atnrw9ew	140	7	characterized	characterize	VBD
cord-323756-atnrw9ew	140	8	DHX36	DHX36	NNP
cord-323756-atnrw9ew	140	9	and	and	CC
cord-323756-atnrw9ew	140	10	DHX9	DHX9	NNP
cord-323756-atnrw9ew	140	11	as	as	IN
cord-323756-atnrw9ew	140	12	a	a	DT
cord-323756-atnrw9ew	140	13	sensor	sensor	NN
cord-323756-atnrw9ew	140	14	for	for	IN
cord-323756-atnrw9ew	140	15	the	the	DT
cord-323756-atnrw9ew	140	16	dsDNA	dsDNA	NNP
cord-323756-atnrw9ew	140	17	species	species	NNP
cord-323756-atnrw9ew	140	18	CpG	CpG	NNP
cord-323756-atnrw9ew	140	19	-	-	:
cord-323756-atnrw9ew	140	20	A	A	NNP
cord-323756-atnrw9ew	140	21	and	and	CC
cord-323756-atnrw9ew	140	22	-B	-b	ADD
cord-323756-atnrw9ew	140	23	,	,	,
cord-323756-atnrw9ew	140	24	respectively	respectively	RB
cord-323756-atnrw9ew	140	25	.	.	.
cord-323756-atnrw9ew	141	1	In	in	IN
cord-323756-atnrw9ew	141	2	this	this	DT
cord-323756-atnrw9ew	141	3	case	case	NN
cord-323756-atnrw9ew	141	4	,	,	,
cord-323756-atnrw9ew	141	5	both	both	CC
cord-323756-atnrw9ew	141	6	DHX36	DHX36	NNP
cord-323756-atnrw9ew	141	7	and	and	CC
cord-323756-atnrw9ew	141	8	DHX9	DHX9	NNP
cord-323756-atnrw9ew	141	9	activate	activate	VBP
cord-323756-atnrw9ew	141	10	the	the	DT
cord-323756-atnrw9ew	141	11	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	141	12	adapter	adapter	NN
cord-323756-atnrw9ew	141	13	protein	protein	NN
cord-323756-atnrw9ew	141	14	myeloid	myeloid	NN
cord-323756-atnrw9ew	141	15	differentiation	differentiation	NN
cord-323756-atnrw9ew	141	16	primary	primary	JJ
cord-323756-atnrw9ew	141	17	response	response	NN
cord-323756-atnrw9ew	141	18	gene	gene	NN
cord-323756-atnrw9ew	141	19	88	88	CD
cord-323756-atnrw9ew	141	20	(	(	-LRB-
cord-323756-atnrw9ew	141	21	MyD88	MyD88	NNS
cord-323756-atnrw9ew	141	22	)	)	-RRB-
cord-323756-atnrw9ew	141	23	by	by	IN
cord-323756-atnrw9ew	141	24	binding	bind	VBG
cord-323756-atnrw9ew	141	25	to	to	IN
cord-323756-atnrw9ew	141	26	its	-PRON-	PRP$
cord-323756-atnrw9ew	141	27	TIR	TIR	NNP
cord-323756-atnrw9ew	141	28	domain	domain	NN
cord-323756-atnrw9ew	141	29	(	(	-LRB-
cord-323756-atnrw9ew	141	30	75	75	CD
cord-323756-atnrw9ew	141	31	)	)	-RRB-
cord-323756-atnrw9ew	141	32	.	.	.
cord-323756-atnrw9ew	142	1	Another	another	DT
cord-323756-atnrw9ew	142	2	recent	recent	JJ
cord-323756-atnrw9ew	142	3	study	study	NN
cord-323756-atnrw9ew	142	4	by	by	IN
cord-323756-atnrw9ew	142	5	Yong	Yong	NNP
cord-323756-atnrw9ew	142	6	-	-	HYPH
cord-323756-atnrw9ew	142	7	Jun	Jun	NNP
cord-323756-atnrw9ew	142	8	Liu	Liu	NNP
cord-323756-atnrw9ew	142	9	's	's	POS
cord-323756-atnrw9ew	142	10	group	group	NN
cord-323756-atnrw9ew	142	11	identified	identify	VBD
cord-323756-atnrw9ew	142	12	another	another	DT
cord-323756-atnrw9ew	142	13	helicase	helicase	NN
cord-323756-atnrw9ew	142	14	,	,	,
cord-323756-atnrw9ew	142	15	DHX33	DHX33	NNP
cord-323756-atnrw9ew	142	16	,	,	,
cord-323756-atnrw9ew	142	17	as	as	IN
cord-323756-atnrw9ew	142	18	a	a	DT
cord-323756-atnrw9ew	142	19	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	142	20	RNA	RNA	NNP
cord-323756-atnrw9ew	142	21	receptor	receptor	NN
cord-323756-atnrw9ew	142	22	able	able	JJ
cord-323756-atnrw9ew	142	23	to	to	TO
cord-323756-atnrw9ew	142	24	activate	activate	VB
cord-323756-atnrw9ew	142	25	the	the	DT
cord-323756-atnrw9ew	142	26	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	142	27	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	142	28	(	(	-LRB-
cord-323756-atnrw9ew	142	29	76	76	CD
cord-323756-atnrw9ew	142	30	)	)	-RRB-
cord-323756-atnrw9ew	142	31	.	.	.
cord-323756-atnrw9ew	143	1	DHX33	DHX33	NNP
cord-323756-atnrw9ew	143	2	is	be	VBZ
cord-323756-atnrw9ew	143	3	involved	involve	VBN
cord-323756-atnrw9ew	143	4	in	in	IN
cord-323756-atnrw9ew	143	5	inflammasome	inflammasome	NN
cord-323756-atnrw9ew	143	6	activation	activation	NN
cord-323756-atnrw9ew	143	7	after	after	IN
cord-323756-atnrw9ew	143	8	sensing	sense	VBG
cord-323756-atnrw9ew	143	9	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	143	10	RNA	RNA	NNP
cord-323756-atnrw9ew	143	11	such	such	JJ
cord-323756-atnrw9ew	143	12	as	as	IN
cord-323756-atnrw9ew	143	13	poly(I	poly(I	NNP
cord-323756-atnrw9ew	143	14	:	:	:
cord-323756-atnrw9ew	143	15	C	C	NNP
cord-323756-atnrw9ew	143	16	)	)	-RRB-
cord-323756-atnrw9ew	143	17	or	or	CC
cord-323756-atnrw9ew	143	18	reoviral	reoviral	NNP
cord-323756-atnrw9ew	143	19	RNA	RNA	NNP
cord-323756-atnrw9ew	143	20	when	when	WRB
cord-323756-atnrw9ew	143	21	directly	directly	RB
cord-323756-atnrw9ew	143	22	delivered	deliver	VBN
cord-323756-atnrw9ew	143	23	by	by	IN
cord-323756-atnrw9ew	143	24	lipofection	lipofection	NN
cord-323756-atnrw9ew	143	25	to	to	IN
cord-323756-atnrw9ew	143	26	the	the	DT
cord-323756-atnrw9ew	143	27	cytoplasm	cytoplasm	NN
cord-323756-atnrw9ew	143	28	of	of	IN
cord-323756-atnrw9ew	143	29	a	a	DT
cord-323756-atnrw9ew	143	30	macrophage	macrophage	NN
cord-323756-atnrw9ew	143	31	cell	cell	NN
cord-323756-atnrw9ew	143	32	line	line	NN
cord-323756-atnrw9ew	143	33	or	or	CC
cord-323756-atnrw9ew	143	34	human	human	JJ
cord-323756-atnrw9ew	143	35	monocyte	monocyte	NN
cord-323756-atnrw9ew	143	36	-	-	HYPH
cord-323756-atnrw9ew	143	37	derived	derive	VBN
cord-323756-atnrw9ew	143	38	macrophages	macrophage	NNS
cord-323756-atnrw9ew	143	39	.	.	.
cord-323756-atnrw9ew	144	1	Additional	additional	JJ
cord-323756-atnrw9ew	144	2	experiments	experiment	NNS
cord-323756-atnrw9ew	144	3	suggested	suggest	VBD
cord-323756-atnrw9ew	144	4	that	that	IN
cord-323756-atnrw9ew	144	5	DHX33	DHX33	NNP
cord-323756-atnrw9ew	144	6	could	could	MD
cord-323756-atnrw9ew	144	7	also	also	RB
cord-323756-atnrw9ew	144	8	possibly	possibly	RB
cord-323756-atnrw9ew	144	9	be	be	VB
cord-323756-atnrw9ew	144	10	involved	involve	VBN
cord-323756-atnrw9ew	144	11	in	in	IN
cord-323756-atnrw9ew	144	12	detection	detection	NN
cord-323756-atnrw9ew	144	13	of	of	IN
cord-323756-atnrw9ew	144	14	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	144	15	bacterial	bacterial	JJ
cord-323756-atnrw9ew	144	16	RNA	RNA	NNP
cord-323756-atnrw9ew	144	17	.	.	.
cord-323756-atnrw9ew	145	1	The	the	DT
cord-323756-atnrw9ew	145	2	authors	author	NNS
cord-323756-atnrw9ew	145	3	showed	show	VBD
cord-323756-atnrw9ew	145	4	that	that	IN
cord-323756-atnrw9ew	145	5	DHX33	DHX33	NNP
cord-323756-atnrw9ew	145	6	can	can	MD
cord-323756-atnrw9ew	145	7	bind	bind	VB
cord-323756-atnrw9ew	145	8	to	to	IN
cord-323756-atnrw9ew	145	9	dsRNA	dsrna	NN
cord-323756-atnrw9ew	145	10	through	through	IN
cord-323756-atnrw9ew	145	11	its	-PRON-	PRP$
cord-323756-atnrw9ew	145	12	helicase	helicase	NN
cord-323756-atnrw9ew	145	13	C	c	NN
cord-323756-atnrw9ew	145	14	domain	domain	NN
cord-323756-atnrw9ew	145	15	and	and	CC
cord-323756-atnrw9ew	145	16	to	to	IN
cord-323756-atnrw9ew	145	17	NLPR3	nlpr3	NN
cord-323756-atnrw9ew	145	18	through	through	IN
cord-323756-atnrw9ew	145	19	its	-PRON-	PRP$
cord-323756-atnrw9ew	145	20	DEAD	dead	JJ
cord-323756-atnrw9ew	145	21	domain	domain	NN
cord-323756-atnrw9ew	145	22	(	(	-LRB-
cord-323756-atnrw9ew	145	23	76	76	CD
cord-323756-atnrw9ew	145	24	)	)	-RRB-
cord-323756-atnrw9ew	145	25	.	.	.
cord-323756-atnrw9ew	146	1	A	a	DT
cord-323756-atnrw9ew	146	2	few	few	JJ
cord-323756-atnrw9ew	146	3	months	month	NNS
cord-323756-atnrw9ew	146	4	later	later	RB
cord-323756-atnrw9ew	146	5	,	,	,
cord-323756-atnrw9ew	146	6	another	another	DT
cord-323756-atnrw9ew	146	7	study	study	NN
cord-323756-atnrw9ew	146	8	performed	perform	VBN
cord-323756-atnrw9ew	146	9	on	on	IN
cord-323756-atnrw9ew	146	10	myeloid	myeloid	NNP
cord-323756-atnrw9ew	146	11	DCs	DCs	NNP
cord-323756-atnrw9ew	146	12	confirmed	confirm	VBD
cord-323756-atnrw9ew	146	13	the	the	DT
cord-323756-atnrw9ew	146	14	role	role	NN
cord-323756-atnrw9ew	146	15	of	of	IN
cord-323756-atnrw9ew	146	16	DHX33	DHX33	NNP
cord-323756-atnrw9ew	146	17	in	in	IN
cord-323756-atnrw9ew	146	18	the	the	DT
cord-323756-atnrw9ew	146	19	sensing	sensing	NN
cord-323756-atnrw9ew	146	20	of	of	IN
cord-323756-atnrw9ew	146	21	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	146	22	poly(I	poly(I	NNP
cord-323756-atnrw9ew	146	23	:	:	:
cord-323756-atnrw9ew	146	24	C	C	NNP
cord-323756-atnrw9ew	146	25	)	)	-RRB-
cord-323756-atnrw9ew	146	26	and	and	CC
cord-323756-atnrw9ew	146	27	reoviral	reoviral	NNP
cord-323756-atnrw9ew	146	28	RNA	RNA	NNP
cord-323756-atnrw9ew	146	29	.	.	.
cord-323756-atnrw9ew	147	1	Surprisingly	surprisingly	RB
cord-323756-atnrw9ew	147	2	,	,	,
cord-323756-atnrw9ew	147	3	in	in	IN
cord-323756-atnrw9ew	147	4	this	this	DT
cord-323756-atnrw9ew	147	5	case	case	NN
cord-323756-atnrw9ew	147	6	,	,	,
cord-323756-atnrw9ew	147	7	poly(I	poly(I	NNP
cord-323756-atnrw9ew	147	8	:	:	:
cord-323756-atnrw9ew	147	9	C)-induced	c)-induced	JJ
cord-323756-atnrw9ew	147	10	activation	activation	NN
cord-323756-atnrw9ew	147	11	of	of	IN
cord-323756-atnrw9ew	147	12	MAPK	MAPK	NNP
cord-323756-atnrw9ew	147	13	,	,	,
cord-323756-atnrw9ew	147	14	NF	NF	NNP
cord-323756-atnrw9ew	147	15	-	-	HYPH
cord-323756-atnrw9ew	147	16	κB	κB	NNP
cord-323756-atnrw9ew	147	17	,	,	,
cord-323756-atnrw9ew	147	18	and	and	CC
cord-323756-atnrw9ew	147	19	IRF3	IRF3	NNP
cord-323756-atnrw9ew	147	20	was	be	VBD
cord-323756-atnrw9ew	147	21	mediated	mediate	VBN
cord-323756-atnrw9ew	147	22	by	by	IN
cord-323756-atnrw9ew	147	23	MAVS	MAVS	NNP
cord-323756-atnrw9ew	147	24	,	,	,
cord-323756-atnrw9ew	147	25	which	which	WDT
cord-323756-atnrw9ew	147	26	binds	bind	VBZ
cord-323756-atnrw9ew	147	27	the	the	DT
cord-323756-atnrw9ew	147	28	helicase	helicase	NN
cord-323756-atnrw9ew	147	29	C	c	NN
cord-323756-atnrw9ew	147	30	domain	domain	NN
cord-323756-atnrw9ew	147	31	of	of	IN
cord-323756-atnrw9ew	147	32	DHX33	DHX33	NNP
cord-323756-atnrw9ew	147	33	(	(	-LRB-
cord-323756-atnrw9ew	147	34	77	77	CD
cord-323756-atnrw9ew	147	35	)	)	-RRB-
cord-323756-atnrw9ew	147	36	.	.	.
cord-323756-atnrw9ew	148	1	DDX60	DDX60	NNP
cord-323756-atnrw9ew	148	2	has	have	VBZ
cord-323756-atnrw9ew	148	3	also	also	RB
cord-323756-atnrw9ew	148	4	been	be	VBN
cord-323756-atnrw9ew	148	5	shown	show	VBN
cord-323756-atnrw9ew	148	6	to	to	TO
cord-323756-atnrw9ew	148	7	enhance	enhance	VB
cord-323756-atnrw9ew	148	8	the	the	DT
cord-323756-atnrw9ew	148	9	IFN	IFN	NNP
cord-323756-atnrw9ew	148	10	-	-	HYPH
cord-323756-atnrw9ew	148	11	I	-PRON-	PRP
cord-323756-atnrw9ew	148	12	response	response	NN
cord-323756-atnrw9ew	148	13	to	to	IN
cord-323756-atnrw9ew	148	14	RNA	RNA	NNP
cord-323756-atnrw9ew	148	15	and	and	CC
cord-323756-atnrw9ew	148	16	DNA	dna	NN
cord-323756-atnrw9ew	148	17	stimulation	stimulation	NN
cord-323756-atnrw9ew	148	18	through	through	IN
cord-323756-atnrw9ew	148	19	formation	formation	NN
cord-323756-atnrw9ew	148	20	of	of	IN
cord-323756-atnrw9ew	148	21	complexes	complex	NNS
cord-323756-atnrw9ew	148	22	with	with	IN
cord-323756-atnrw9ew	148	23	Frontiers	Frontiers	NNPS
cord-323756-atnrw9ew	148	24	in	in	IN
cord-323756-atnrw9ew	148	25	Immunology	Immunology	NNP
cord-323756-atnrw9ew	148	26	|	|	NNP
cord-323756-atnrw9ew	149	1	Molecular	molecular	JJ
cord-323756-atnrw9ew	149	2	Innate	Innate	NNP
cord-323756-atnrw9ew	149	3	Immunity	Immunity	NNP
cord-323756-atnrw9ew	149	4	RIG	rig	NN
cord-323756-atnrw9ew	149	5	-	-	:
cord-323756-atnrw9ew	149	6	I	I	NNP
cord-323756-atnrw9ew	149	7	,	,	,
cord-323756-atnrw9ew	149	8	MDA5	MDA5	NNP
cord-323756-atnrw9ew	149	9	,	,	,
cord-323756-atnrw9ew	149	10	and	and	CC
cord-323756-atnrw9ew	149	11	LGP2	LGP2	NNP
cord-323756-atnrw9ew	149	12	but	but	CC
cord-323756-atnrw9ew	149	13	not	not	RB
cord-323756-atnrw9ew	149	14	with	with	IN
cord-323756-atnrw9ew	149	15	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	149	16	.	.	.
cord-323756-atnrw9ew	150	1	This	this	DT
cord-323756-atnrw9ew	150	2	complex	complex	JJ
cord-323756-atnrw9ew	150	3	formation	formation	NN
cord-323756-atnrw9ew	150	4	has	have	VBZ
cord-323756-atnrw9ew	150	5	been	be	VBN
cord-323756-atnrw9ew	150	6	deciphered	decipher	VBN
cord-323756-atnrw9ew	150	7	with	with	IN
cord-323756-atnrw9ew	150	8	overexpression	overexpression	NN
cord-323756-atnrw9ew	150	9	assays	assay	NNS
cord-323756-atnrw9ew	150	10	in	in	IN
cord-323756-atnrw9ew	150	11	the	the	DT
cord-323756-atnrw9ew	150	12	case	case	NN
cord-323756-atnrw9ew	150	13	of	of	IN
cord-323756-atnrw9ew	150	14	MDA5	MDA5	NNP
cord-323756-atnrw9ew	150	15	and	and	CC
cord-323756-atnrw9ew	150	16	LGP2	LGP2	NNP
cord-323756-atnrw9ew	150	17	,	,	,
cord-323756-atnrw9ew	150	18	and	and	CC
cord-323756-atnrw9ew	150	19	with	with	IN
cord-323756-atnrw9ew	150	20	endogenous	endogenous	JJ
cord-323756-atnrw9ew	150	21	RIG	rig	NN
cord-323756-atnrw9ew	150	22	-	-	:
cord-323756-atnrw9ew	150	23	I	-PRON-	PRP
cord-323756-atnrw9ew	150	24	during	during	IN
cord-323756-atnrw9ew	150	25	VSV	VSV	NNP
cord-323756-atnrw9ew	150	26	infection	infection	NN
cord-323756-atnrw9ew	150	27	.	.	.
cord-323756-atnrw9ew	151	1	DDX60	ddx60	NN
cord-323756-atnrw9ew	151	2	expression	expression	NN
cord-323756-atnrw9ew	151	3	is	be	VBZ
cord-323756-atnrw9ew	151	4	induced	induce	VBN
cord-323756-atnrw9ew	151	5	by	by	IN
cord-323756-atnrw9ew	151	6	viral	viral	JJ
cord-323756-atnrw9ew	151	7	infection	infection	NN
cord-323756-atnrw9ew	151	8	and	and	CC
cord-323756-atnrw9ew	151	9	its	-PRON-	PRP$
cord-323756-atnrw9ew	151	10	helicase	helicase	NN
cord-323756-atnrw9ew	151	11	domain	domain	NN
cord-323756-atnrw9ew	151	12	can	can	MD
cord-323756-atnrw9ew	151	13	bind	bind	VB
cord-323756-atnrw9ew	151	14	ds	ds	NNP
cord-323756-atnrw9ew	151	15	-	-	HYPH
cord-323756-atnrw9ew	151	16	or	or	CC
cord-323756-atnrw9ew	151	17	ss	ss	NNP
cord-323756-atnrw9ew	151	18	-	-	NNP
cord-323756-atnrw9ew	151	19	VSV	VSV	NNP
cord-323756-atnrw9ew	151	20	RNA	RNA	NNP
cord-323756-atnrw9ew	151	21	generated	generate	VBN
cord-323756-atnrw9ew	151	22	in	in	IN
cord-323756-atnrw9ew	151	23	vitro	vitro	FW
cord-323756-atnrw9ew	151	24	,	,	,
cord-323756-atnrw9ew	151	25	independently	independently	RB
cord-323756-atnrw9ew	151	26	of	of	IN
cord-323756-atnrw9ew	151	27	the	the	DT
cord-323756-atnrw9ew	151	28	5	5	CD
cord-323756-atnrw9ew	151	29	-ppp	-ppp	:
cord-323756-atnrw9ew	151	30	(	(	-LRB-
cord-323756-atnrw9ew	151	31	78	78	CD
cord-323756-atnrw9ew	151	32	)	)	-RRB-
cord-323756-atnrw9ew	151	33	.	.	.
cord-323756-atnrw9ew	152	1	Interestingly	interestingly	RB
cord-323756-atnrw9ew	152	2	,	,	,
cord-323756-atnrw9ew	152	3	DDX60	DDX60	NNP
cord-323756-atnrw9ew	152	4	can	can	MD
cord-323756-atnrw9ew	152	5	also	also	RB
cord-323756-atnrw9ew	152	6	bind	bind	VB
cord-323756-atnrw9ew	152	7	dsDNA	dsdna	RB
cord-323756-atnrw9ew	152	8	,	,	,
cord-323756-atnrw9ew	152	9	and	and	CC
cord-323756-atnrw9ew	152	10	was	be	VBD
cord-323756-atnrw9ew	152	11	shown	show	VBN
cord-323756-atnrw9ew	152	12	to	to	TO
cord-323756-atnrw9ew	152	13	play	play	VB
cord-323756-atnrw9ew	152	14	role	role	NN
cord-323756-atnrw9ew	152	15	in	in	IN
cord-323756-atnrw9ew	152	16	IFN-	IFN-	NNP
cord-323756-atnrw9ew	153	1	I	-PRON-	PRP
cord-323756-atnrw9ew	153	2	expression	expression	NN
cord-323756-atnrw9ew	153	3	after	after	IN
cord-323756-atnrw9ew	153	4	infection	infection	NN
cord-323756-atnrw9ew	153	5	with	with	IN
cord-323756-atnrw9ew	153	6	Herpes	Herpes	NNP
cord-323756-atnrw9ew	153	7	Simplex	Simplex	NNP
cord-323756-atnrw9ew	153	8	Virus-1	Virus-1	NNP
cord-323756-atnrw9ew	153	9	,	,	,
cord-323756-atnrw9ew	153	10	a	a	DT
cord-323756-atnrw9ew	153	11	DNA	dna	NN
cord-323756-atnrw9ew	153	12	virus	virus	NN
cord-323756-atnrw9ew	153	13	.	.	.
cord-323756-atnrw9ew	154	1	This	this	DT
cord-323756-atnrw9ew	154	2	ability	ability	NN
cord-323756-atnrw9ew	154	3	to	to	TO
cord-323756-atnrw9ew	154	4	bind	bind	VB
cord-323756-atnrw9ew	154	5	both	both	DT
cord-323756-atnrw9ew	154	6	dsRNA	dsRNA	NNS
cord-323756-atnrw9ew	154	7	and	and	CC
cord-323756-atnrw9ew	154	8	DNA	DNA	NNP
cord-323756-atnrw9ew	154	9	raises	raise	VBZ
cord-323756-atnrw9ew	154	10	the	the	DT
cord-323756-atnrw9ew	154	11	question	question	NN
cord-323756-atnrw9ew	154	12	of	of	IN
cord-323756-atnrw9ew	154	13	the	the	DT
cord-323756-atnrw9ew	154	14	feature	feature	NN
cord-323756-atnrw9ew	154	15	DDX60	DDX60	NNP
cord-323756-atnrw9ew	154	16	recognizes	recognize	VBZ
cord-323756-atnrw9ew	154	17	.	.	.
cord-323756-atnrw9ew	155	1	It	-PRON-	PRP
cord-323756-atnrw9ew	155	2	should	should	MD
cord-323756-atnrw9ew	155	3	be	be	VB
cord-323756-atnrw9ew	155	4	finally	finally	RB
cord-323756-atnrw9ew	155	5	noted	note	VBN
cord-323756-atnrw9ew	155	6	that	that	IN
cord-323756-atnrw9ew	155	7	the	the	DT
cord-323756-atnrw9ew	155	8	role	role	NN
cord-323756-atnrw9ew	155	9	of	of	IN
cord-323756-atnrw9ew	155	10	DDX60	DDX60	NNP
cord-323756-atnrw9ew	155	11	in	in	IN
cord-323756-atnrw9ew	155	12	the	the	DT
cord-323756-atnrw9ew	155	13	IFN	IFN	NNP
cord-323756-atnrw9ew	155	14	-	-	HYPH
cord-323756-atnrw9ew	155	15	I	I	NNP
cord-323756-atnrw9ew	155	16	pathway	pathway	NN
cord-323756-atnrw9ew	155	17	has	have	VBZ
cord-323756-atnrw9ew	155	18	been	be	VBN
cord-323756-atnrw9ew	155	19	questioned	question	VBN
cord-323756-atnrw9ew	155	20	(	(	-LRB-
cord-323756-atnrw9ew	155	21	79	79	CD
cord-323756-atnrw9ew	155	22	)	)	-RRB-
cord-323756-atnrw9ew	155	23	.	.	.
cord-323756-atnrw9ew	156	1	Several	several	JJ
cord-323756-atnrw9ew	156	2	other	other	JJ
cord-323756-atnrw9ew	156	3	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	156	4	receptors	receptor	NNS
cord-323756-atnrw9ew	156	5	have	have	VBP
cord-323756-atnrw9ew	156	6	been	be	VBN
cord-323756-atnrw9ew	156	7	shown	show	VBN
cord-323756-atnrw9ew	156	8	to	to	TO
cord-323756-atnrw9ew	156	9	play	play	VB
cord-323756-atnrw9ew	156	10	a	a	DT
cord-323756-atnrw9ew	156	11	role	role	NN
cord-323756-atnrw9ew	156	12	in	in	IN
cord-323756-atnrw9ew	156	13	microbial	microbial	JJ
cord-323756-atnrw9ew	156	14	RNA	RNA	NNP
cord-323756-atnrw9ew	156	15	recognition	recognition	NN
cord-323756-atnrw9ew	156	16	.	.	.
cord-323756-atnrw9ew	157	1	This	this	DT
cord-323756-atnrw9ew	157	2	is	be	VBZ
cord-323756-atnrw9ew	157	3	the	the	DT
cord-323756-atnrw9ew	157	4	case	case	NN
cord-323756-atnrw9ew	157	5	for	for	IN
cord-323756-atnrw9ew	157	6	the	the	DT
cord-323756-atnrw9ew	157	7	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	157	8	protein	protein	NN
cord-323756-atnrw9ew	157	9	kinase	kinase	NN
cord-323756-atnrw9ew	157	10	R	r	NN
cord-323756-atnrw9ew	157	11	(	(	-LRB-
cord-323756-atnrw9ew	157	12	PKR	PKR	NNP
cord-323756-atnrw9ew	157	13	)	)	-RRB-
cord-323756-atnrw9ew	157	14	,	,	,
cord-323756-atnrw9ew	157	15	which	which	WDT
cord-323756-atnrw9ew	157	16	is	be	VBZ
cord-323756-atnrw9ew	157	17	important	important	JJ
cord-323756-atnrw9ew	157	18	for	for	IN
cord-323756-atnrw9ew	157	19	antiviral	antiviral	JJ
cord-323756-atnrw9ew	157	20	activity	activity	NN
cord-323756-atnrw9ew	157	21	.	.	.
cord-323756-atnrw9ew	158	1	PKR	PKR	NNP
cord-323756-atnrw9ew	158	2	is	be	VBZ
cord-323756-atnrw9ew	158	3	activated	activate	VBN
cord-323756-atnrw9ew	158	4	by	by	IN
cord-323756-atnrw9ew	158	5	dsRNA	dsrna	NN
cord-323756-atnrw9ew	158	6	from	from	IN
cord-323756-atnrw9ew	158	7	viruses	virus	NNS
cord-323756-atnrw9ew	158	8	and	and	CC
cord-323756-atnrw9ew	158	9	is	be	VBZ
cord-323756-atnrw9ew	158	10	a	a	DT
cord-323756-atnrw9ew	158	11	component	component	NN
cord-323756-atnrw9ew	158	12	of	of	IN
cord-323756-atnrw9ew	158	13	MAPK	MAPK	NNP
cord-323756-atnrw9ew	158	14	and	and	CC
cord-323756-atnrw9ew	158	15	NF	NF	NNP
cord-323756-atnrw9ew	158	16	-	-	HYPH
cord-323756-atnrw9ew	158	17	κB	κB	NNP
cord-323756-atnrw9ew	158	18	signaling	signal	VBG
cord-323756-atnrw9ew	158	19	pathways	pathway	NNS
cord-323756-atnrw9ew	158	20	[	[	-LRB-
cord-323756-atnrw9ew	158	21	reviewed	review	VBN
cord-323756-atnrw9ew	158	22	in	in	IN
cord-323756-atnrw9ew	158	23	Ref	Ref	NNP
cord-323756-atnrw9ew	158	24	.	.	.
cord-323756-atnrw9ew	159	1	(	(	-LRB-
cord-323756-atnrw9ew	159	2	80	80	CD
cord-323756-atnrw9ew	159	3	)	)	-RRB-
cord-323756-atnrw9ew	159	4	]	]	-RRB-
cord-323756-atnrw9ew	159	5	.	.	.
cord-323756-atnrw9ew	160	1	Activation	activation	NN
cord-323756-atnrw9ew	160	2	of	of	IN
cord-323756-atnrw9ew	160	3	PKR	PKR	NNP
cord-323756-atnrw9ew	160	4	can	can	MD
cord-323756-atnrw9ew	160	5	also	also	RB
cord-323756-atnrw9ew	160	6	be	be	VB
cord-323756-atnrw9ew	160	7	mediated	mediate	VBN
cord-323756-atnrw9ew	160	8	by	by	IN
cord-323756-atnrw9ew	160	9	short	short	JJ
cord-323756-atnrw9ew	160	10	5	5	CD
cord-323756-atnrw9ew	161	1	-ppp	-ppp	:
cord-323756-atnrw9ew	161	2	RNAs	rna	NNS
cord-323756-atnrw9ew	161	3	containing	contain	VBG
cord-323756-atnrw9ew	161	4	limited	limited	JJ
cord-323756-atnrw9ew	161	5	secondary	secondary	JJ
cord-323756-atnrw9ew	161	6	structures	structure	NNS
cord-323756-atnrw9ew	161	7	(	(	-LRB-
cord-323756-atnrw9ew	161	8	81	81	CD
cord-323756-atnrw9ew	161	9	)	)	-RRB-
cord-323756-atnrw9ew	161	10	.	.	.
cord-323756-atnrw9ew	162	1	Proteins	protein	NNS
cord-323756-atnrw9ew	162	2	from	from	IN
cord-323756-atnrw9ew	162	3	the	the	DT
cord-323756-atnrw9ew	162	4	Interferon	Interferon	NNP
cord-323756-atnrw9ew	162	5	-	-	HYPH
cord-323756-atnrw9ew	162	6	induced	induce	VBN
cord-323756-atnrw9ew	162	7	protein	protein	NN
cord-323756-atnrw9ew	162	8	with	with	IN
cord-323756-atnrw9ew	162	9	tetratricopeptide	tetratricopeptide	NNP
cord-323756-atnrw9ew	162	10	repeats	repeat	VBZ
cord-323756-atnrw9ew	163	1	(	(	-LRB-
cord-323756-atnrw9ew	163	2	IFITs	IFITs	NNP
cord-323756-atnrw9ew	163	3	)	)	-RRB-
cord-323756-atnrw9ew	163	4	family	family	NN
cord-323756-atnrw9ew	163	5	,	,	,
cord-323756-atnrw9ew	163	6	such	such	JJ
cord-323756-atnrw9ew	163	7	as	as	IN
cord-323756-atnrw9ew	163	8	IFIT1	ifit1	JJ
cord-323756-atnrw9ew	163	9	and	and	CC
cord-323756-atnrw9ew	163	10	5	5	CD
cord-323756-atnrw9ew	163	11	,	,	,
cord-323756-atnrw9ew	163	12	bind	bind	VB
cord-323756-atnrw9ew	163	13	5	5	CD
cord-323756-atnrw9ew	163	14	-ppp	-ppp	:
cord-323756-atnrw9ew	163	15	of	of	IN
cord-323756-atnrw9ew	163	16	viral	viral	JJ
cord-323756-atnrw9ew	163	17	RNA	RNA	NNP
cord-323756-atnrw9ew	163	18	(	(	-LRB-
cord-323756-atnrw9ew	163	19	82	82	CD
cord-323756-atnrw9ew	163	20	)	)	-RRB-
cord-323756-atnrw9ew	163	21	.	.	.
cord-323756-atnrw9ew	164	1	Using	use	VBG
cord-323756-atnrw9ew	164	2	short	short	JJ
cord-323756-atnrw9ew	164	3	in	in	IN
cord-323756-atnrw9ew	164	4	vitro	vitro	FW
cord-323756-atnrw9ew	164	5	transcribed	transcribe	VBN
cord-323756-atnrw9ew	164	6	oligonucleotides	oligonucleotide	NNS
cord-323756-atnrw9ew	164	7	,	,	,
cord-323756-atnrw9ew	164	8	crystal	crystal	NN
cord-323756-atnrw9ew	164	9	structure	structure	NN
cord-323756-atnrw9ew	164	10	studies	study	NNS
cord-323756-atnrw9ew	164	11	have	have	VBP
cord-323756-atnrw9ew	164	12	demonstrated	demonstrate	VBN
cord-323756-atnrw9ew	164	13	that	that	IN
cord-323756-atnrw9ew	164	14	IFIT	ifit	NN
cord-323756-atnrw9ew	164	15	proteins	protein	NNS
cord-323756-atnrw9ew	164	16	contain	contain	VBP
cord-323756-atnrw9ew	164	17	a	a	DT
cord-323756-atnrw9ew	164	18	positively	positively	RB
cord-323756-atnrw9ew	164	19	charged	charge	VBN
cord-323756-atnrw9ew	164	20	cavity	cavity	NN
cord-323756-atnrw9ew	164	21	designed	design	VBN
cord-323756-atnrw9ew	164	22	to	to	TO
cord-323756-atnrw9ew	164	23	engage	engage	VB
cord-323756-atnrw9ew	164	24	,	,	,
cord-323756-atnrw9ew	164	25	without	without	IN
cord-323756-atnrw9ew	164	26	any	any	DT
cord-323756-atnrw9ew	164	27	particular	particular	JJ
cord-323756-atnrw9ew	164	28	sequence	sequence	NN
cord-323756-atnrw9ew	164	29	specificity	specificity	NN
cord-323756-atnrw9ew	164	30	,	,	,
cord-323756-atnrw9ew	164	31	ssRNA	ssRNA	VBG
cord-323756-atnrw9ew	164	32	with	with	IN
cord-323756-atnrw9ew	164	33	a	a	DT
cord-323756-atnrw9ew	164	34	5	5	CD
cord-323756-atnrw9ew	164	35	-ppp	-ppp	NN
cord-323756-atnrw9ew	164	36	end	end	NN
cord-323756-atnrw9ew	164	37	.	.	.
cord-323756-atnrw9ew	165	1	Contrary	contrary	JJ
cord-323756-atnrw9ew	165	2	to	to	IN
cord-323756-atnrw9ew	165	3	RIG	rig	NN
cord-323756-atnrw9ew	165	4	-	-	:
cord-323756-atnrw9ew	165	5	I	i	NN
cord-323756-atnrw9ew	165	6	,	,	,
cord-323756-atnrw9ew	165	7	IFIT	ifit	NN
cord-323756-atnrw9ew	165	8	proteins	protein	NNS
cord-323756-atnrw9ew	165	9	can	can	MD
cord-323756-atnrw9ew	165	10	not	not	RB
cord-323756-atnrw9ew	165	11	bind	bind	VB
cord-323756-atnrw9ew	165	12	blunt	blunt	JJ
cord-323756-atnrw9ew	165	13	-	-	HYPH
cord-323756-atnrw9ew	165	14	ended	end	VBN
cord-323756-atnrw9ew	165	15	5	5	CD
cord-323756-atnrw9ew	165	16	-ppp	-ppp	SYM
cord-323756-atnrw9ew	165	17	dsRNA	dsrna	NN
cord-323756-atnrw9ew	165	18	,	,	,
cord-323756-atnrw9ew	165	19	and	and	CC
cord-323756-atnrw9ew	165	20	owing	owe	VBG
cord-323756-atnrw9ew	165	21	to	to	IN
cord-323756-atnrw9ew	165	22	the	the	DT
cord-323756-atnrw9ew	165	23	limitations	limitation	NNS
cord-323756-atnrw9ew	165	24	imposed	impose	VBN
cord-323756-atnrw9ew	165	25	by	by	IN
cord-323756-atnrw9ew	165	26	their	-PRON-	PRP$
cord-323756-atnrw9ew	165	27	RNA	RNA	NNP
cord-323756-atnrw9ew	165	28	-	-	HYPH
cord-323756-atnrw9ew	165	29	binding	bind	VBG
cord-323756-atnrw9ew	165	30	pockets	pocket	NNS
cord-323756-atnrw9ew	165	31	,	,	,
cord-323756-atnrw9ew	165	32	IFIT1	ifit1	VB
cord-323756-atnrw9ew	165	33	and	and	CC
cord-323756-atnrw9ew	165	34	IFIT5	IFIT5	MD
cord-323756-atnrw9ew	165	35	require	require	VB
cord-323756-atnrw9ew	165	36	5'-overhangs	5'-overhangs	CD
cord-323756-atnrw9ew	165	37	of	of	IN
cord-323756-atnrw9ew	165	38	at	at	RB
cord-323756-atnrw9ew	165	39	least	least	JJS
cord-323756-atnrw9ew	165	40	5	5	CD
cord-323756-atnrw9ew	165	41	or	or	CC
cord-323756-atnrw9ew	165	42	3	3	CD
cord-323756-atnrw9ew	165	43	nt	nt	RB
cord-323756-atnrw9ew	165	44	,	,	,
cord-323756-atnrw9ew	165	45	respectively	respectively	RB
cord-323756-atnrw9ew	165	46	(	(	-LRB-
cord-323756-atnrw9ew	165	47	83	83	CD
cord-323756-atnrw9ew	165	48	)	)	-RRB-
cord-323756-atnrw9ew	165	49	.	.	.
cord-323756-atnrw9ew	166	1	Using	use	VBG
cord-323756-atnrw9ew	166	2	a	a	DT
cord-323756-atnrw9ew	166	3	2	2	CD
cord-323756-atnrw9ew	166	4	-O	-o	JJ
cord-323756-atnrw9ew	166	5	-	-	HYPH
cord-323756-atnrw9ew	166	6	methyltransferase	methyltransferase	JJ
cord-323756-atnrw9ew	166	7	mutant	mutant	NN
cord-323756-atnrw9ew	166	8	of	of	IN
cord-323756-atnrw9ew	166	9	Japanese	japanese	JJ
cord-323756-atnrw9ew	166	10	encephalitis	encephalitis	RB
cord-323756-atnrw9ew	166	11	virus	virus	NN
cord-323756-atnrw9ew	166	12	,	,	,
cord-323756-atnrw9ew	166	13	another	another	DT
cord-323756-atnrw9ew	166	14	study	study	NN
cord-323756-atnrw9ew	166	15	showed	show	VBD
cord-323756-atnrw9ew	166	16	that	that	IN
cord-323756-atnrw9ew	166	17	IFIT1	ifit1	PRP
cord-323756-atnrw9ew	166	18	preferentially	preferentially	RB
cord-323756-atnrw9ew	166	19	binds	bind	VBZ
cord-323756-atnrw9ew	166	20	to	to	IN
cord-323756-atnrw9ew	166	21	5	5	CD
cord-323756-atnrw9ew	166	22	capped	cap	VBN
cord-323756-atnrw9ew	166	23	2	2	CD
cord-323756-atnrw9ew	166	24	-O	-o	RBS
cord-323756-atnrw9ew	166	25	-	-	HYPH
cord-323756-atnrw9ew	166	26	unmethylated	unmethylated	JJ
cord-323756-atnrw9ew	166	27	mRNA	mrna	NN
cord-323756-atnrw9ew	166	28	(	(	-LRB-
cord-323756-atnrw9ew	166	29	84	84	CD
cord-323756-atnrw9ew	166	30	)	)	-RRB-
cord-323756-atnrw9ew	166	31	,	,	,
cord-323756-atnrw9ew	166	32	confirming	confirm	VBG
cord-323756-atnrw9ew	166	33	previous	previous	JJ
cord-323756-atnrw9ew	166	34	findings	finding	NNS
cord-323756-atnrw9ew	166	35	showing	show	VBG
cord-323756-atnrw9ew	166	36	that	that	IN
cord-323756-atnrw9ew	166	37	2	2	CD
cord-323756-atnrw9ew	166	38	-O	-o	VB
cord-323756-atnrw9ew	166	39	-	-	HYPH
cord-323756-atnrw9ew	166	40	methylation	methylation	NN
cord-323756-atnrw9ew	166	41	of	of	IN
cord-323756-atnrw9ew	166	42	viral	viral	JJ
cord-323756-atnrw9ew	166	43	mRNA	mrna	NN
cord-323756-atnrw9ew	166	44	caps	cap	NNS
cord-323756-atnrw9ew	166	45	promotes	promote	VBZ
cord-323756-atnrw9ew	166	46	IFIT1	ifit1	JJ
cord-323756-atnrw9ew	166	47	evasion	evasion	NN
cord-323756-atnrw9ew	166	48	(	(	-LRB-
cord-323756-atnrw9ew	166	49	85	85	CD
cord-323756-atnrw9ew	166	50	,	,	,
cord-323756-atnrw9ew	166	51	86	86	CD
cord-323756-atnrw9ew	166	52	)	)	-RRB-
cord-323756-atnrw9ew	166	53	.	.	.
cord-323756-atnrw9ew	167	1	The	the	DT
cord-323756-atnrw9ew	167	2	mechanism	mechanism	NN
cord-323756-atnrw9ew	167	3	of	of	IN
cord-323756-atnrw9ew	167	4	IFIT1	ifit1	JJ
cord-323756-atnrw9ew	167	5	antiviral	antiviral	JJ
cord-323756-atnrw9ew	167	6	action	action	NN
cord-323756-atnrw9ew	167	7	is	be	VBZ
cord-323756-atnrw9ew	167	8	not	not	RB
cord-323756-atnrw9ew	167	9	completely	completely	RB
cord-323756-atnrw9ew	167	10	understood	understand	VBN
cord-323756-atnrw9ew	167	11	,	,	,
cord-323756-atnrw9ew	167	12	and	and	CC
cord-323756-atnrw9ew	167	13	it	-PRON-	PRP
cord-323756-atnrw9ew	167	14	has	have	VBZ
cord-323756-atnrw9ew	167	15	been	be	VBN
cord-323756-atnrw9ew	167	16	proposed	propose	VBN
cord-323756-atnrw9ew	167	17	that	that	IN
cord-323756-atnrw9ew	167	18	IFIT	IFIT	NNP
cord-323756-atnrw9ew	167	19	might	may	MD
cord-323756-atnrw9ew	167	20	sequester	sequester	VB
cord-323756-atnrw9ew	167	21	viral	viral	JJ
cord-323756-atnrw9ew	167	22	RNAs	rna	NNS
cord-323756-atnrw9ew	167	23	(	(	-LRB-
cord-323756-atnrw9ew	167	24	82	82	CD
cord-323756-atnrw9ew	167	25	)	)	-RRB-
cord-323756-atnrw9ew	167	26	or	or	CC
cord-323756-atnrw9ew	167	27	inhibit	inhibit	VB
cord-323756-atnrw9ew	167	28	viral	viral	JJ
cord-323756-atnrw9ew	167	29	mRNA	mrna	NN
cord-323756-atnrw9ew	167	30	translation	translation	NN
cord-323756-atnrw9ew	167	31	(	(	-LRB-
cord-323756-atnrw9ew	167	32	84	84	CD
cord-323756-atnrw9ew	167	33	)	)	-RRB-
cord-323756-atnrw9ew	167	34	.	.	.
cord-323756-atnrw9ew	168	1	The	the	DT
cord-323756-atnrw9ew	168	2	crystal	crystal	NN
cord-323756-atnrw9ew	168	3	structure	structure	NN
cord-323756-atnrw9ew	168	4	of	of	IN
cord-323756-atnrw9ew	168	5	IFIT2	IFIT2	NNP
cord-323756-atnrw9ew	168	6	(	(	-LRB-
cord-323756-atnrw9ew	168	7	known	know	VBN
cord-323756-atnrw9ew	168	8	as	as	IN
cord-323756-atnrw9ew	168	9	ISG54	ISG54	NNP
cord-323756-atnrw9ew	168	10	)	)	-RRB-
cord-323756-atnrw9ew	168	11	was	be	VBD
cord-323756-atnrw9ew	168	12	also	also	RB
cord-323756-atnrw9ew	168	13	described	describe	VBN
cord-323756-atnrw9ew	168	14	.	.	.
cord-323756-atnrw9ew	169	1	IFIT2	IFIT2	NNP
cord-323756-atnrw9ew	169	2	specifically	specifically	RB
cord-323756-atnrw9ew	169	3	binds	bind	VBZ
cord-323756-atnrw9ew	169	4	adenylate	adenylate	NN
cord-323756-atnrw9ew	169	5	uridylate	uridylate	NN
cord-323756-atnrw9ew	169	6	(	(	-LRB-
cord-323756-atnrw9ew	169	7	AU)rich	AU)rich	NNP
cord-323756-atnrw9ew	169	8	RNAs	rna	NNS
cord-323756-atnrw9ew	169	9	in	in	IN
cord-323756-atnrw9ew	169	10	vitro	vitro	FW
cord-323756-atnrw9ew	169	11	,	,	,
cord-323756-atnrw9ew	169	12	independently	independently	RB
cord-323756-atnrw9ew	169	13	of	of	IN
cord-323756-atnrw9ew	169	14	the	the	DT
cord-323756-atnrw9ew	169	15	presence	presence	NN
cord-323756-atnrw9ew	169	16	of	of	IN
cord-323756-atnrw9ew	169	17	a	a	DT
cord-323756-atnrw9ew	169	18	5	5	CD
cord-323756-atnrw9ew	169	19	-ppp	-ppp	:
cord-323756-atnrw9ew	169	20	(	(	-LRB-
cord-323756-atnrw9ew	169	21	87	87	CD
cord-323756-atnrw9ew	169	22	)	)	-RRB-
cord-323756-atnrw9ew	169	23	.	.	.
cord-323756-atnrw9ew	170	1	The	the	DT
cord-323756-atnrw9ew	170	2	authors	author	NNS
cord-323756-atnrw9ew	170	3	showed	show	VBD
cord-323756-atnrw9ew	170	4	that	that	IN
cord-323756-atnrw9ew	170	5	RNA	rna	NN
cord-323756-atnrw9ew	170	6	-	-	HYPH
cord-323756-atnrw9ew	170	7	binding	bind	VBG
cord-323756-atnrw9ew	170	8	capacity	capacity	NN
cord-323756-atnrw9ew	170	9	of	of	IN
cord-323756-atnrw9ew	170	10	this	this	DT
cord-323756-atnrw9ew	170	11	protein	protein	NN
cord-323756-atnrw9ew	170	12	mediates	mediate	VBZ
cord-323756-atnrw9ew	170	13	its	-PRON-	PRP$
cord-323756-atnrw9ew	170	14	antiviral	antiviral	JJ
cord-323756-atnrw9ew	170	15	properties	property	NNS
cord-323756-atnrw9ew	170	16	,	,	,
cord-323756-atnrw9ew	170	17	using	use	VBG
cord-323756-atnrw9ew	170	18	a	a	DT
cord-323756-atnrw9ew	170	19	model	model	NN
cord-323756-atnrw9ew	170	20	of	of	IN
cord-323756-atnrw9ew	170	21	HEK293	HEK293	NNP
cord-323756-atnrw9ew	170	22	T	T	NNP
cord-323756-atnrw9ew	170	23	cells	cell	NNS
cord-323756-atnrw9ew	170	24	infected	infect	VBN
cord-323756-atnrw9ew	170	25	by	by	IN
cord-323756-atnrw9ew	170	26	Newcastle	Newcastle	NNP
cord-323756-atnrw9ew	170	27	disease	disease	NN
cord-323756-atnrw9ew	170	28	virus	virus	NN
cord-323756-atnrw9ew	170	29	or	or	CC
cord-323756-atnrw9ew	170	30	SeV	sev	NN
cord-323756-atnrw9ew	170	31	(	(	-LRB-
cord-323756-atnrw9ew	170	32	87	87	CD
cord-323756-atnrw9ew	170	33	)	)	-RRB-
cord-323756-atnrw9ew	170	34	.	.	.
cord-323756-atnrw9ew	171	1	Nucleotide	nucleotide	NN
cord-323756-atnrw9ew	171	2	-	-	HYPH
cord-323756-atnrw9ew	171	3	binding	bind	VBG
cord-323756-atnrw9ew	171	4	oligomerization	oligomerization	NN
cord-323756-atnrw9ew	171	5	domain	domain	NN
cord-323756-atnrw9ew	171	6	containing	contain	VBG
cord-323756-atnrw9ew	171	7	protein	protein	NN
cord-323756-atnrw9ew	171	8	2	2	CD
cord-323756-atnrw9ew	171	9	(	(	-LRB-
cord-323756-atnrw9ew	171	10	NOD2	NOD2	NNP
cord-323756-atnrw9ew	171	11	)	)	-RRB-
cord-323756-atnrw9ew	171	12	is	be	VBZ
cord-323756-atnrw9ew	171	13	a	a	DT
cord-323756-atnrw9ew	171	14	member	member	NN
cord-323756-atnrw9ew	171	15	of	of	IN
cord-323756-atnrw9ew	171	16	the	the	DT
cord-323756-atnrw9ew	171	17	NOD1	NOD1	NNP
cord-323756-atnrw9ew	171	18	/	/	SYM
cord-323756-atnrw9ew	171	19	Apaf-1	Apaf-1	NNP
cord-323756-atnrw9ew	171	20	family	family	NN
cord-323756-atnrw9ew	171	21	and	and	CC
cord-323756-atnrw9ew	171	22	encodes	encode	VBZ
cord-323756-atnrw9ew	171	23	a	a	DT
cord-323756-atnrw9ew	171	24	protein	protein	NN
cord-323756-atnrw9ew	171	25	with	with	IN
cord-323756-atnrw9ew	171	26	two	two	CD
cord-323756-atnrw9ew	171	27	CARD	card	NN
cord-323756-atnrw9ew	171	28	domains	domain	NNS
cord-323756-atnrw9ew	171	29	and	and	CC
cord-323756-atnrw9ew	171	30	six	six	CD
cord-323756-atnrw9ew	171	31	leucinerich	leucinerich	NNS
cord-323756-atnrw9ew	171	32	repeats	repeat	VBZ
cord-323756-atnrw9ew	171	33	(	(	-LRB-
cord-323756-atnrw9ew	171	34	LRRs	LRRs	NNP
cord-323756-atnrw9ew	171	35	)	)	-RRB-
cord-323756-atnrw9ew	171	36	.	.	.
cord-323756-atnrw9ew	172	1	NOD2	NOD2	NNP
cord-323756-atnrw9ew	172	2	is	be	VBZ
cord-323756-atnrw9ew	172	3	primarily	primarily	RB
cord-323756-atnrw9ew	172	4	known	know	VBN
cord-323756-atnrw9ew	172	5	for	for	IN
cord-323756-atnrw9ew	172	6	its	-PRON-	PRP$
cord-323756-atnrw9ew	172	7	ability	ability	NN
cord-323756-atnrw9ew	172	8	to	to	TO
cord-323756-atnrw9ew	172	9	recognize	recognize	VB
cord-323756-atnrw9ew	172	10	bacterial	bacterial	JJ
cord-323756-atnrw9ew	172	11	peptidoglycan	peptidoglycan	NN
cord-323756-atnrw9ew	172	12	,	,	,
cord-323756-atnrw9ew	172	13	but	but	CC
cord-323756-atnrw9ew	172	14	it	-PRON-	PRP
cord-323756-atnrw9ew	172	15	also	also	RB
cord-323756-atnrw9ew	172	16	plays	play	VBZ
cord-323756-atnrw9ew	172	17	a	a	DT
cord-323756-atnrw9ew	172	18	role	role	NN
cord-323756-atnrw9ew	172	19	in	in	IN
cord-323756-atnrw9ew	172	20	the	the	DT
cord-323756-atnrw9ew	172	21	antiviral	antiviral	JJ
cord-323756-atnrw9ew	172	22	response	response	NN
cord-323756-atnrw9ew	172	23	.	.	.
cord-323756-atnrw9ew	173	1	NOD2	NOD2	NNP
cord-323756-atnrw9ew	173	2	has	have	VBZ
cord-323756-atnrw9ew	173	3	been	be	VBN
cord-323756-atnrw9ew	173	4	shown	show	VBN
cord-323756-atnrw9ew	173	5	to	to	TO
cord-323756-atnrw9ew	173	6	activate	activate	VB
cord-323756-atnrw9ew	173	7	MAVS	MAVS	NNP
cord-323756-atnrw9ew	173	8	after	after	IN
cord-323756-atnrw9ew	173	9	stimulation	stimulation	NN
cord-323756-atnrw9ew	173	10	with	with	IN
cord-323756-atnrw9ew	173	11	viral	viral	JJ
cord-323756-atnrw9ew	173	12	ssRNA	ssrna	NN
cord-323756-atnrw9ew	173	13	or	or	CC
cord-323756-atnrw9ew	173	14	human	human	JJ
cord-323756-atnrw9ew	173	15	respiratory	respiratory	JJ
cord-323756-atnrw9ew	173	16	syncytial	syncytial	JJ
cord-323756-atnrw9ew	173	17	virus	virus	NN
cord-323756-atnrw9ew	173	18	infection	infection	NN
cord-323756-atnrw9ew	173	19	(	(	-LRB-
cord-323756-atnrw9ew	173	20	88	88	CD
cord-323756-atnrw9ew	173	21	)	)	-RRB-
cord-323756-atnrw9ew	173	22	.	.	.
cord-323756-atnrw9ew	174	1	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	174	2	is	be	VBZ
cord-323756-atnrw9ew	174	3	involved	involve	VBN
cord-323756-atnrw9ew	174	4	in	in	IN
cord-323756-atnrw9ew	174	5	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	174	6	RNA	RNA	NNP
cord-323756-atnrw9ew	174	7	sensing	sensing	NN
cord-323756-atnrw9ew	174	8	.	.	.
cord-323756-atnrw9ew	175	1	Caspase-1	caspase-1	NN
cord-323756-atnrw9ew	175	2	cleavage	cleavage	NN
cord-323756-atnrw9ew	175	3	triggered	trigger	VBN
cord-323756-atnrw9ew	175	4	by	by	IN
cord-323756-atnrw9ew	175	5	influenza	influenza	NN
cord-323756-atnrw9ew	175	6	virus	virus	NN
cord-323756-atnrw9ew	175	7	,	,	,
cord-323756-atnrw9ew	175	8	SeV	sev	NN
cord-323756-atnrw9ew	175	9	,	,	,
cord-323756-atnrw9ew	175	10	or	or	CC
cord-323756-atnrw9ew	175	11	bacterial	bacterial	JJ
cord-323756-atnrw9ew	175	12	mRNA	mrna	NN
cord-323756-atnrw9ew	175	13	is	be	VBZ
cord-323756-atnrw9ew	175	14	dependent	dependent	JJ
cord-323756-atnrw9ew	175	15	on	on	IN
cord-323756-atnrw9ew	175	16	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	175	17	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	175	18	activation	activation	NN
cord-323756-atnrw9ew	175	19	(	(	-LRB-
cord-323756-atnrw9ew	175	20	7	7	CD
cord-323756-atnrw9ew	175	21	,	,	,
cord-323756-atnrw9ew	175	22	89	89	CD
cord-323756-atnrw9ew	175	23	,	,	,
cord-323756-atnrw9ew	175	24	90	90	CD
cord-323756-atnrw9ew	175	25	)	)	-RRB-
cord-323756-atnrw9ew	175	26	.	.	.
cord-323756-atnrw9ew	176	1	However	however	RB
cord-323756-atnrw9ew	176	2	,	,	,
cord-323756-atnrw9ew	176	3	direct	direct	JJ
cord-323756-atnrw9ew	176	4	binding	binding	NN
cord-323756-atnrw9ew	176	5	of	of	IN
cord-323756-atnrw9ew	176	6	NOD2	NOD2	NNPS
cord-323756-atnrw9ew	176	7	or	or	CC
cord-323756-atnrw9ew	176	8	NLRP3	nlrp3	NN
cord-323756-atnrw9ew	176	9	to	to	IN
cord-323756-atnrw9ew	176	10	microbial	microbial	JJ
cord-323756-atnrw9ew	176	11	RNA	RNA	NNP
cord-323756-atnrw9ew	176	12	has	have	VBZ
cord-323756-atnrw9ew	176	13	not	not	RB
cord-323756-atnrw9ew	176	14	been	be	VBN
cord-323756-atnrw9ew	176	15	established	establish	VBN
cord-323756-atnrw9ew	176	16	.	.	.
cord-323756-atnrw9ew	177	1	Leucine	leucine	NN
cord-323756-atnrw9ew	177	2	-	-	HYPH
cord-323756-atnrw9ew	177	3	rich	rich	JJ
cord-323756-atnrw9ew	177	4	repeat	repeat	NN
cord-323756-atnrw9ew	178	1	flightless	flightless	NN
cord-323756-atnrw9ew	178	2	-	-	HYPH
cord-323756-atnrw9ew	178	3	interacting	interact	VBG
cord-323756-atnrw9ew	178	4	protein	protein	NN
cord-323756-atnrw9ew	178	5	1	1	CD
cord-323756-atnrw9ew	178	6	(	(	-LRB-
cord-323756-atnrw9ew	178	7	LRRFIP1	lrrfip1	NN
cord-323756-atnrw9ew	178	8	)	)	-RRB-
cord-323756-atnrw9ew	178	9	contributes	contribute	VBZ
cord-323756-atnrw9ew	178	10	to	to	IN
cord-323756-atnrw9ew	178	11	the	the	DT
cord-323756-atnrw9ew	178	12	production	production	NN
cord-323756-atnrw9ew	178	13	of	of	IN
cord-323756-atnrw9ew	178	14	IFN	IFN	NNP
cord-323756-atnrw9ew	178	15	-	-	HYPH
cord-323756-atnrw9ew	178	16	β	β	NN
cord-323756-atnrw9ew	178	17	induced	induce	VBN
cord-323756-atnrw9ew	178	18	by	by	IN
cord-323756-atnrw9ew	178	19	VSV	VSV	NNP
cord-323756-atnrw9ew	178	20	and	and	CC
cord-323756-atnrw9ew	178	21	L.	L.	NNP
cord-323756-atnrw9ew	178	22	monocytogenes	monocytogenes	NN
cord-323756-atnrw9ew	178	23	in	in	IN
cord-323756-atnrw9ew	178	24	macrophages	macrophage	NNS
cord-323756-atnrw9ew	178	25	(	(	-LRB-
cord-323756-atnrw9ew	178	26	91	91	CD
cord-323756-atnrw9ew	178	27	)	)	-RRB-
cord-323756-atnrw9ew	178	28	.	.	.
cord-323756-atnrw9ew	179	1	Mostly	mostly	RB
cord-323756-atnrw9ew	179	2	located	locate	VBN
cord-323756-atnrw9ew	179	3	in	in	IN
cord-323756-atnrw9ew	179	4	the	the	DT
cord-323756-atnrw9ew	179	5	cytosol	cytosol	NN
cord-323756-atnrw9ew	179	6	,	,	,
cord-323756-atnrw9ew	179	7	LRRFIP1	lrrfip1	NN
cord-323756-atnrw9ew	179	8	can	can	MD
cord-323756-atnrw9ew	179	9	also	also	RB
cord-323756-atnrw9ew	179	10	be	be	VB
cord-323756-atnrw9ew	179	11	found	find	VBN
cord-323756-atnrw9ew	179	12	in	in	IN
cord-323756-atnrw9ew	179	13	RNA	RNA	NNP
cord-323756-atnrw9ew	179	14	-	-	HYPH
cord-323756-atnrw9ew	179	15	containing	contain	VBG
cord-323756-atnrw9ew	179	16	lysosomes	lysosome	NNS
cord-323756-atnrw9ew	179	17	(	(	-LRB-
cord-323756-atnrw9ew	179	18	92	92	CD
cord-323756-atnrw9ew	179	19	)	)	-RRB-
cord-323756-atnrw9ew	179	20	.	.	.
cord-323756-atnrw9ew	180	1	LRRFIP1	LRRFIP1	NNP
cord-323756-atnrw9ew	180	2	can	can	MD
cord-323756-atnrw9ew	180	3	bind	bind	VB
cord-323756-atnrw9ew	180	4	both	both	DT
cord-323756-atnrw9ew	180	5	dsRNA	dsRNA	.
cord-323756-atnrw9ew	181	1	and	and	CC
cord-323756-atnrw9ew	181	2	dsDNA	dsdna	RB
cord-323756-atnrw9ew	181	3	and	and	CC
cord-323756-atnrw9ew	181	4	subsequently	subsequently	RB
cord-323756-atnrw9ew	181	5	induce	induce	VB
cord-323756-atnrw9ew	181	6	IFN	IFN	NNP
cord-323756-atnrw9ew	181	7	-	-	HYPH
cord-323756-atnrw9ew	181	8	I	-PRON-	PRP
cord-323756-atnrw9ew	181	9	expression	expression	NN
cord-323756-atnrw9ew	181	10	through	through	IN
cord-323756-atnrw9ew	181	11	β	β	NN
cord-323756-atnrw9ew	181	12	-	-	HYPH
cord-323756-atnrw9ew	181	13	catenin	catenin	NNP
cord-323756-atnrw9ew	181	14	phosphorylation	phosphorylation	NN
cord-323756-atnrw9ew	181	15	.	.	.
cord-323756-atnrw9ew	182	1	Activated	activate	VBN
cord-323756-atnrw9ew	182	2	β	β	NN
cord-323756-atnrw9ew	182	3	-	-	HYPH
cord-323756-atnrw9ew	182	4	catenin	catenin	NNP
cord-323756-atnrw9ew	182	5	is	be	VBZ
cord-323756-atnrw9ew	182	6	translocated	translocate	VBN
cord-323756-atnrw9ew	182	7	to	to	IN
cord-323756-atnrw9ew	182	8	the	the	DT
cord-323756-atnrw9ew	182	9	nucleus	nucleus	NN
cord-323756-atnrw9ew	182	10	and	and	CC
cord-323756-atnrw9ew	182	11	increases	increase	VBZ
cord-323756-atnrw9ew	182	12	IFN	IFN	NNP
cord-323756-atnrw9ew	182	13	-	-	HYPH
cord-323756-atnrw9ew	182	14	β	β	NNP
cord-323756-atnrw9ew	182	15	expression	expression	NN
cord-323756-atnrw9ew	182	16	by	by	IN
cord-323756-atnrw9ew	182	17	binding	bind	VBG
cord-323756-atnrw9ew	182	18	to	to	IN
cord-323756-atnrw9ew	182	19	the	the	DT
cord-323756-atnrw9ew	182	20	C	C	NNP
cord-323756-atnrw9ew	182	21	-	-	HYPH
cord-323756-atnrw9ew	182	22	terminal	terminal	NN
cord-323756-atnrw9ew	182	23	domain	domain	NN
cord-323756-atnrw9ew	182	24	of	of	IN
cord-323756-atnrw9ew	182	25	the	the	DT
cord-323756-atnrw9ew	182	26	transcription	transcription	NN
cord-323756-atnrw9ew	182	27	factor	factor	NN
cord-323756-atnrw9ew	182	28	IRF3	IRF3	NNP
cord-323756-atnrw9ew	182	29	and	and	CC
cord-323756-atnrw9ew	182	30	promoting	promote	VBG
cord-323756-atnrw9ew	182	31	the	the	DT
cord-323756-atnrw9ew	182	32	recruitment	recruitment	NN
cord-323756-atnrw9ew	182	33	of	of	IN
cord-323756-atnrw9ew	182	34	the	the	DT
cord-323756-atnrw9ew	182	35	acetyltransferase	acetyltransferase	NNP
cord-323756-atnrw9ew	182	36	p300	p300	NNP
cord-323756-atnrw9ew	182	37	to	to	IN
cord-323756-atnrw9ew	182	38	the	the	DT
cord-323756-atnrw9ew	182	39	Ifnb1	ifnb1	JJ
cord-323756-atnrw9ew	182	40	promoter	promoter	NN
cord-323756-atnrw9ew	182	41	.	.	.
cord-323756-atnrw9ew	183	1	Several	several	JJ
cord-323756-atnrw9ew	183	2	other	other	JJ
cord-323756-atnrw9ew	183	3	microbial	microbial	NN
cord-323756-atnrw9ew	183	4	RNA	RNA	NNP
cord-323756-atnrw9ew	183	5	features	feature	NNS
cord-323756-atnrw9ew	183	6	have	have	VBP
cord-323756-atnrw9ew	183	7	been	be	VBN
cord-323756-atnrw9ew	183	8	suspected	suspect	VBN
cord-323756-atnrw9ew	183	9	or	or	CC
cord-323756-atnrw9ew	183	10	proposed	propose	VBN
cord-323756-atnrw9ew	183	11	to	to	TO
cord-323756-atnrw9ew	183	12	act	act	VB
cord-323756-atnrw9ew	183	13	as	as	IN
cord-323756-atnrw9ew	183	14	potential	potential	JJ
cord-323756-atnrw9ew	183	15	signals	signal	NNS
cord-323756-atnrw9ew	183	16	for	for	IN
cord-323756-atnrw9ew	183	17	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	183	18	sensing	sensing	NN
cord-323756-atnrw9ew	183	19	,	,	,
cord-323756-atnrw9ew	183	20	suggesting	suggest	VBG
cord-323756-atnrw9ew	183	21	the	the	DT
cord-323756-atnrw9ew	183	22	existence	existence	NN
cord-323756-atnrw9ew	183	23	of	of	IN
cord-323756-atnrw9ew	183	24	receptors	receptor	NNS
cord-323756-atnrw9ew	183	25	detecting	detect	VBG
cord-323756-atnrw9ew	183	26	these	these	DT
cord-323756-atnrw9ew	183	27	characteristics	characteristic	NNS
cord-323756-atnrw9ew	183	28	.	.	.
cord-323756-atnrw9ew	184	1	A	a	DT
cord-323756-atnrw9ew	184	2	computational	computational	JJ
cord-323756-atnrw9ew	184	3	analysis	analysis	NN
cord-323756-atnrw9ew	184	4	identified	identify	VBD
cord-323756-atnrw9ew	184	5	CpG	CpG	NNP
cord-323756-atnrw9ew	184	6	motifs	motif	NNS
cord-323756-atnrw9ew	184	7	in	in	IN
cord-323756-atnrw9ew	184	8	an	an	DT
cord-323756-atnrw9ew	184	9	AU	AU	NNP
cord-323756-atnrw9ew	184	10	-	-	HYPH
cord-323756-atnrw9ew	184	11	rich	rich	JJ
cord-323756-atnrw9ew	184	12	RNA	RNA	NNP
cord-323756-atnrw9ew	184	13	as	as	IN
cord-323756-atnrw9ew	184	14	an	an	DT
cord-323756-atnrw9ew	184	15	immunostimulatory	immunostimulatory	NN
cord-323756-atnrw9ew	184	16	feature	feature	NN
cord-323756-atnrw9ew	184	17	.	.	.
cord-323756-atnrw9ew	185	1	This	this	DT
cord-323756-atnrw9ew	185	2	sequence	sequence	NN
cord-323756-atnrw9ew	185	3	motif	motif	NN
cord-323756-atnrw9ew	185	4	is	be	VBZ
cord-323756-atnrw9ew	185	5	underrepresented	underrepresente	VBN
cord-323756-atnrw9ew	185	6	in	in	IN
cord-323756-atnrw9ew	185	7	both	both	DT
cord-323756-atnrw9ew	185	8	ssRNA	ssrna	NN
cord-323756-atnrw9ew	185	9	viruses	virus	NNS
cord-323756-atnrw9ew	185	10	and	and	CC
cord-323756-atnrw9ew	185	11	host	host	NN
cord-323756-atnrw9ew	185	12	innate	innate	JJ
cord-323756-atnrw9ew	185	13	immune	immune	JJ
cord-323756-atnrw9ew	185	14	gene	gene	NN
cord-323756-atnrw9ew	185	15	mRNA	mrna	NN
cord-323756-atnrw9ew	185	16	,	,	,
cord-323756-atnrw9ew	185	17	and	and	CC
cord-323756-atnrw9ew	185	18	its	-PRON-	PRP$
cord-323756-atnrw9ew	185	19	frequency	frequency	NN
cord-323756-atnrw9ew	185	20	in	in	IN
cord-323756-atnrw9ew	185	21	influenza	influenza	NN
cord-323756-atnrw9ew	185	22	virus	virus	NN
cord-323756-atnrw9ew	185	23	genomes	genome	NNS
cord-323756-atnrw9ew	185	24	has	have	VBZ
cord-323756-atnrw9ew	185	25	decreased	decrease	VBN
cord-323756-atnrw9ew	185	26	throughout	throughout	IN
cord-323756-atnrw9ew	185	27	evolution	evolution	NN
cord-323756-atnrw9ew	185	28	(	(	-LRB-
cord-323756-atnrw9ew	185	29	93	93	CD
cord-323756-atnrw9ew	185	30	)	)	-RRB-
cord-323756-atnrw9ew	185	31	.	.	.
cord-323756-atnrw9ew	186	1	Since	since	IN
cord-323756-atnrw9ew	186	2	this	this	DT
cord-323756-atnrw9ew	186	3	evolutionary	evolutionary	JJ
cord-323756-atnrw9ew	186	4	pressure	pressure	NN
cord-323756-atnrw9ew	186	5	seems	seem	VBZ
cord-323756-atnrw9ew	186	6	to	to	TO
cord-323756-atnrw9ew	186	7	also	also	RB
cord-323756-atnrw9ew	186	8	be	be	VB
cord-323756-atnrw9ew	186	9	applied	apply	VBN
cord-323756-atnrw9ew	186	10	on	on	IN
cord-323756-atnrw9ew	186	11	host	host	NN
cord-323756-atnrw9ew	186	12	mRNA	mrna	NN
cord-323756-atnrw9ew	186	13	,	,	,
cord-323756-atnrw9ew	186	14	the	the	DT
cord-323756-atnrw9ew	186	15	implication	implication	NN
cord-323756-atnrw9ew	186	16	of	of	IN
cord-323756-atnrw9ew	186	17	a	a	DT
cord-323756-atnrw9ew	186	18	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	186	19	receptor	receptor	NN
cord-323756-atnrw9ew	186	20	is	be	VBZ
cord-323756-atnrw9ew	186	21	possible	possible	JJ
cord-323756-atnrw9ew	186	22	,	,	,
cord-323756-atnrw9ew	186	23	although	although	IN
cord-323756-atnrw9ew	186	24	experimental	experimental	JJ
cord-323756-atnrw9ew	186	25	studies	study	NNS
cord-323756-atnrw9ew	186	26	identified	identify	VBD
cord-323756-atnrw9ew	186	27	endosomal	endosomal	NNP
cord-323756-atnrw9ew	186	28	TLR7	TLR7	NNP
cord-323756-atnrw9ew	186	29	as	as	IN
cord-323756-atnrw9ew	186	30	a	a	DT
cord-323756-atnrw9ew	186	31	potential	potential	JJ
cord-323756-atnrw9ew	186	32	PRR	PRR	NNP
cord-323756-atnrw9ew	186	33	(	(	-LRB-
cord-323756-atnrw9ew	186	34	94	94	CD
cord-323756-atnrw9ew	186	35	)	)	-RRB-
cord-323756-atnrw9ew	186	36	.	.	.
cord-323756-atnrw9ew	187	1	Another	another	DT
cord-323756-atnrw9ew	187	2	study	study	NN
cord-323756-atnrw9ew	187	3	identified	identify	VBD
cord-323756-atnrw9ew	187	4	the	the	DT
cord-323756-atnrw9ew	187	5	nucleotide	nucleotide	JJ
cord-323756-atnrw9ew	187	6	bias	bias	NN
cord-323756-atnrw9ew	187	7	of	of	IN
cord-323756-atnrw9ew	187	8	A	a	DT
cord-323756-atnrw9ew	187	9	-	-	HYPH
cord-323756-atnrw9ew	187	10	rich	rich	JJ
cord-323756-atnrw9ew	187	11	HIV-1	HIV-1	NNP
cord-323756-atnrw9ew	187	12	genome	genome	NN
cord-323756-atnrw9ew	187	13	as	as	IN
cord-323756-atnrw9ew	187	14	a	a	DT
cord-323756-atnrw9ew	187	15	strong	strong	JJ
cord-323756-atnrw9ew	187	16	inducer	inducer	NN
cord-323756-atnrw9ew	187	17	of	of	IN
cord-323756-atnrw9ew	187	18	IFN	IFN	NNP
cord-323756-atnrw9ew	187	19	-	-	HYPH
cord-323756-atnrw9ew	187	20	I	I	NNP
cord-323756-atnrw9ew	187	21	and	and	CC
cord-323756-atnrw9ew	187	22	potent	potent	JJ
cord-323756-atnrw9ew	187	23	mediator	mediator	NN
cord-323756-atnrw9ew	187	24	of	of	IN
cord-323756-atnrw9ew	187	25	lentiviral	lentiviral	JJ
cord-323756-atnrw9ew	187	26	pathogenicity	pathogenicity	NN
cord-323756-atnrw9ew	187	27	.	.	.
cord-323756-atnrw9ew	188	1	The	the	DT
cord-323756-atnrw9ew	188	2	authors	author	NNS
cord-323756-atnrw9ew	188	3	showed	show	VBD
cord-323756-atnrw9ew	188	4	that	that	IN
cord-323756-atnrw9ew	188	5	the	the	DT
cord-323756-atnrw9ew	188	6	ability	ability	NN
cord-323756-atnrw9ew	188	7	of	of	IN
cord-323756-atnrw9ew	188	8	RNA	RNA	NNP
cord-323756-atnrw9ew	188	9	sequences	sequence	NNS
cord-323756-atnrw9ew	188	10	derived	derive	VBN
cord-323756-atnrw9ew	188	11	from	from	IN
cord-323756-atnrw9ew	188	12	the	the	DT
cord-323756-atnrw9ew	188	13	HIV-1	HIV-1	NNP
cord-323756-atnrw9ew	188	14	genome	genome	NN
cord-323756-atnrw9ew	188	15	to	to	TO
cord-323756-atnrw9ew	188	16	induce	induce	VB
cord-323756-atnrw9ew	188	17	an	an	DT
cord-323756-atnrw9ew	188	18	interferon	interferon	NN
cord-323756-atnrw9ew	188	19	response	response	NN
cord-323756-atnrw9ew	188	20	correlated	correlate	VBN
cord-323756-atnrw9ew	188	21	with	with	IN
cord-323756-atnrw9ew	188	22	their	-PRON-	PRP$
cord-323756-atnrw9ew	188	23	nucleotide	nucleotide	JJ
cord-323756-atnrw9ew	188	24	bias	bias	NN
cord-323756-atnrw9ew	188	25	and	and	CC
cord-323756-atnrw9ew	188	26	that	that	DT
cord-323756-atnrw9ew	188	27	codon	codon	NN
cord-323756-atnrw9ew	188	28	-	-	HYPH
cord-323756-atnrw9ew	188	29	optimized	optimize	VBN
cord-323756-atnrw9ew	188	30	sequences	sequence	NNS
cord-323756-atnrw9ew	188	31	lost	lose	VBD
cord-323756-atnrw9ew	188	32	their	-PRON-	PRP$
cord-323756-atnrw9ew	188	33	stimulatory	stimulatory	JJ
cord-323756-atnrw9ew	188	34	activity	activity	NN
cord-323756-atnrw9ew	188	35	(	(	-LRB-
cord-323756-atnrw9ew	188	36	95	95	CD
cord-323756-atnrw9ew	188	37	)	)	-RRB-
cord-323756-atnrw9ew	188	38	.	.	.
cord-323756-atnrw9ew	189	1	The	the	DT
cord-323756-atnrw9ew	189	2	experimental	experimental	JJ
cord-323756-atnrw9ew	189	3	procedure	procedure	NN
cord-323756-atnrw9ew	189	4	used	use	VBN
cord-323756-atnrw9ew	189	5	in	in	IN
cord-323756-atnrw9ew	189	6	this	this	DT
cord-323756-atnrw9ew	189	7	study	study	NN
cord-323756-atnrw9ew	189	8	consisted	consist	VBD
cord-323756-atnrw9ew	189	9	of	of	IN
cord-323756-atnrw9ew	189	10	direct	direct	JJ
cord-323756-atnrw9ew	189	11	delivery	delivery	NN
cord-323756-atnrw9ew	189	12	via	via	IN
cord-323756-atnrw9ew	189	13	lipofection	lipofection	NN
cord-323756-atnrw9ew	189	14	of	of	IN
cord-323756-atnrw9ew	189	15	in	in	FW
cord-323756-atnrw9ew	189	16	vitro	vitro	FW
cord-323756-atnrw9ew	189	17	transcribed	transcribe	VBN
cord-323756-atnrw9ew	189	18	RNA	RNA	NNP
cord-323756-atnrw9ew	189	19	sequences	sequence	NNS
cord-323756-atnrw9ew	189	20	into	into	IN
cord-323756-atnrw9ew	189	21	the	the	DT
cord-323756-atnrw9ew	189	22	cytosol	cytosol	NN
cord-323756-atnrw9ew	189	23	of	of	IN
cord-323756-atnrw9ew	189	24	a	a	DT
cord-323756-atnrw9ew	189	25	reporter	reporter	NN
cord-323756-atnrw9ew	189	26	cell	cell	NN
cord-323756-atnrw9ew	189	27	line	line	NN
cord-323756-atnrw9ew	189	28	,	,	,
cord-323756-atnrw9ew	189	29	suggesting	suggest	VBG
cord-323756-atnrw9ew	189	30	a	a	DT
cord-323756-atnrw9ew	189	31	potential	potential	JJ
cord-323756-atnrw9ew	189	32	role	role	NN
cord-323756-atnrw9ew	189	33	for	for	IN
cord-323756-atnrw9ew	189	34	a	a	DT
cord-323756-atnrw9ew	189	35	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	189	36	RNA	rna	NN
cord-323756-atnrw9ew	189	37	sensor	sensor	NN
cord-323756-atnrw9ew	189	38	(	(	-LRB-
cord-323756-atnrw9ew	189	39	95	95	CD
cord-323756-atnrw9ew	189	40	)	)	-RRB-
cord-323756-atnrw9ew	189	41	.	.	.
cord-323756-atnrw9ew	190	1	Recently	recently	RB
cord-323756-atnrw9ew	190	2	,	,	,
cord-323756-atnrw9ew	190	3	our	-PRON-	PRP$
cord-323756-atnrw9ew	190	4	group	group	NN
cord-323756-atnrw9ew	190	5	identified	identify	VBD
cord-323756-atnrw9ew	190	6	bacterial	bacterial	JJ
cord-323756-atnrw9ew	190	7	mRNAs	mrna	VBD
cord-323756-atnrw9ew	190	8	as	as	IN
cord-323756-atnrw9ew	190	9	an	an	DT
cord-323756-atnrw9ew	190	10	activator	activator	NN
cord-323756-atnrw9ew	190	11	of	of	IN
cord-323756-atnrw9ew	190	12	the	the	DT
cord-323756-atnrw9ew	190	13	NLRP3	NLRP3	NNP
cord-323756-atnrw9ew	190	14	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	190	15	.	.	.
cord-323756-atnrw9ew	191	1	Polyadenylation	Polyadenylation	NNP
cord-323756-atnrw9ew	191	2	of	of	IN
cord-323756-atnrw9ew	191	3	these	these	DT
cord-323756-atnrw9ew	191	4	RNAs	rna	NNS
cord-323756-atnrw9ew	191	5	abrogated	abrogate	VBD
cord-323756-atnrw9ew	191	6	their	-PRON-	PRP$
cord-323756-atnrw9ew	191	7	immunostimulatory	immunostimulatory	NN
cord-323756-atnrw9ew	191	8	activities	activity	NNS
cord-323756-atnrw9ew	191	9	,	,	,
cord-323756-atnrw9ew	191	10	suggesting	suggest	VBG
cord-323756-atnrw9ew	191	11	that	that	IN
cord-323756-atnrw9ew	191	12	features	feature	VBZ
cord-323756-atnrw9ew	191	13	at	at	IN
cord-323756-atnrw9ew	191	14	the	the	DT
cord-323756-atnrw9ew	191	15	3	3	CD
cord-323756-atnrw9ew	191	16	end	end	NN
cord-323756-atnrw9ew	191	17	of	of	IN
cord-323756-atnrw9ew	191	18	mRNA	mrna	NN
cord-323756-atnrw9ew	191	19	,	,	,
cord-323756-atnrw9ew	191	20	rather	rather	RB
cord-323756-atnrw9ew	191	21	than	than	IN
cord-323756-atnrw9ew	191	22	the	the	DT
cord-323756-atnrw9ew	191	23	5	5	CD
cord-323756-atnrw9ew	191	24	end	end	NN
cord-323756-atnrw9ew	191	25	,	,	,
cord-323756-atnrw9ew	191	26	could	could	MD
cord-323756-atnrw9ew	191	27	engage	engage	VB
cord-323756-atnrw9ew	191	28	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	191	29	cellular	cellular	JJ
cord-323756-atnrw9ew	191	30	sensors	sensor	NNS
cord-323756-atnrw9ew	191	31	(	(	-LRB-
cord-323756-atnrw9ew	191	32	7	7	CD
cord-323756-atnrw9ew	191	33	)	)	-RRB-
cord-323756-atnrw9ew	191	34	.	.	.
cord-323756-atnrw9ew	192	1	Philip	Philip	NNP
cord-323756-atnrw9ew	192	2	Bevilacqua	Bevilacqua	NNP
cord-323756-atnrw9ew	192	3	's	's	POS
cord-323756-atnrw9ew	192	4	group	group	NN
cord-323756-atnrw9ew	192	5	has	have	VBZ
cord-323756-atnrw9ew	192	6	shown	show	VBN
cord-323756-atnrw9ew	192	7	that	that	IN
cord-323756-atnrw9ew	192	8	different	different	JJ
cord-323756-atnrw9ew	192	9	nucleoside	nucleoside	NN
cord-323756-atnrw9ew	192	10	modifications	modification	NNS
cord-323756-atnrw9ew	192	11	on	on	IN
cord-323756-atnrw9ew	192	12	RNA	RNA	NNP
cord-323756-atnrw9ew	192	13	,	,	,
cord-323756-atnrw9ew	192	14	such	such	JJ
cord-323756-atnrw9ew	192	15	as	as	IN
cord-323756-atnrw9ew	192	16	base	base	NN
cord-323756-atnrw9ew	192	17	or	or	CC
cord-323756-atnrw9ew	192	18	sugar	sugar	VB
cord-323756-atnrw9ew	192	19	internal	internal	JJ
cord-323756-atnrw9ew	192	20	modifications	modification	NNS
cord-323756-atnrw9ew	192	21	,	,	,
cord-323756-atnrw9ew	192	22	suppress	suppress	VB
cord-323756-atnrw9ew	192	23	their	-PRON-	PRP$
cord-323756-atnrw9ew	192	24	intrinsic	intrinsic	JJ
cord-323756-atnrw9ew	192	25	ability	ability	NN
cord-323756-atnrw9ew	192	26	to	to	TO
cord-323756-atnrw9ew	192	27	activate	activate	VB
cord-323756-atnrw9ew	192	28	immune	immune	JJ
cord-323756-atnrw9ew	192	29	sensors	sensor	NNS
cord-323756-atnrw9ew	192	30	,	,	,
cord-323756-atnrw9ew	192	31	notably	notably	RB
cord-323756-atnrw9ew	192	32	PKR	PKR	NNP
cord-323756-atnrw9ew	192	33	.	.	.
cord-323756-atnrw9ew	193	1	The	the	DT
cord-323756-atnrw9ew	193	2	authors	author	NNS
cord-323756-atnrw9ew	193	3	propose	propose	VBP
cord-323756-atnrw9ew	193	4	that	that	IN
cord-323756-atnrw9ew	193	5	self	self	NN
cord-323756-atnrw9ew	193	6	-	-	HYPH
cord-323756-atnrw9ew	193	7	RNA	RNA	NNP
cord-323756-atnrw9ew	193	8	editing	editing	NN
cord-323756-atnrw9ew	193	9	could	could	MD
cord-323756-atnrw9ew	193	10	be	be	VB
cord-323756-atnrw9ew	193	11	a	a	DT
cord-323756-atnrw9ew	193	12	mechanism	mechanism	NN
cord-323756-atnrw9ew	193	13	used	use	VBN
cord-323756-atnrw9ew	193	14	by	by	IN
cord-323756-atnrw9ew	193	15	the	the	DT
cord-323756-atnrw9ew	193	16	innate	innate	JJ
cord-323756-atnrw9ew	193	17	immune	immune	JJ
cord-323756-atnrw9ew	193	18	system	system	NN
cord-323756-atnrw9ew	193	19	to	to	TO
cord-323756-atnrw9ew	193	20	discriminate	discriminate	VB
cord-323756-atnrw9ew	193	21	self	self	NN
cord-323756-atnrw9ew	193	22	-	-	HYPH
cord-323756-atnrw9ew	193	23	transcripts	transcript	NNS
cord-323756-atnrw9ew	193	24	from	from	IN
cord-323756-atnrw9ew	193	25	"	"	``
cord-323756-atnrw9ew	193	26	unmodified	unmodified	JJ
cord-323756-atnrw9ew	193	27	"	"	''
cord-323756-atnrw9ew	193	28	microbial	microbial	JJ
cord-323756-atnrw9ew	193	29	RNAs	rna	NNS
cord-323756-atnrw9ew	193	30	(	(	-LRB-
cord-323756-atnrw9ew	193	31	96	96	CD
cord-323756-atnrw9ew	193	32	,	,	,
cord-323756-atnrw9ew	193	33	97	97	CD
cord-323756-atnrw9ew	193	34	)	)	-RRB-
cord-323756-atnrw9ew	193	35	.	.	.
cord-323756-atnrw9ew	194	1	Conversely	conversely	RB
cord-323756-atnrw9ew	194	2	,	,	,
cord-323756-atnrw9ew	194	3	microbial	microbial	JJ
cord-323756-atnrw9ew	194	4	RNA	RNA	NNP
cord-323756-atnrw9ew	194	5	editing	editing	NN
cord-323756-atnrw9ew	194	6	by	by	IN
cord-323756-atnrw9ew	194	7	cellular	cellular	JJ
cord-323756-atnrw9ew	194	8	deaminase	deaminase	NN
cord-323756-atnrw9ew	194	9	enzymes	enzyme	NNS
cord-323756-atnrw9ew	194	10	such	such	JJ
cord-323756-atnrw9ew	194	11	as	as	IN
cord-323756-atnrw9ew	194	12	dsRNA	dsrna	JJ
cord-323756-atnrw9ew	194	13	-	-	HYPH
cord-323756-atnrw9ew	194	14	specific	specific	JJ
cord-323756-atnrw9ew	194	15	adenosine	adenosine	NN
cord-323756-atnrw9ew	194	16	deaminase	deaminase	NNP
cord-323756-atnrw9ew	194	17	(	(	-LRB-
cord-323756-atnrw9ew	194	18	ADAR	ADAR	NNP
cord-323756-atnrw9ew	194	19	)	)	-RRB-
cord-323756-atnrw9ew	194	20	have	have	VBP
cord-323756-atnrw9ew	194	21	been	be	VBN
cord-323756-atnrw9ew	194	22	shown	show	VBN
cord-323756-atnrw9ew	194	23	to	to	TO
cord-323756-atnrw9ew	194	24	enhance	enhance	VB
cord-323756-atnrw9ew	194	25	its	-PRON-	PRP$
cord-323756-atnrw9ew	194	26	recognition	recognition	NN
cord-323756-atnrw9ew	194	27	by	by	IN
cord-323756-atnrw9ew	194	28	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	194	29	sensors	sensor	NNS
cord-323756-atnrw9ew	194	30	(	(	-LRB-
cord-323756-atnrw9ew	194	31	98	98	CD
cord-323756-atnrw9ew	194	32	)	)	-RRB-
cord-323756-atnrw9ew	194	33	.	.	.
cord-323756-atnrw9ew	195	1	Other	other	JJ
cord-323756-atnrw9ew	195	2	host	host	NN
cord-323756-atnrw9ew	195	3	transcript	transcript	NN
cord-323756-atnrw9ew	195	4	specificities	specificity	NNS
cord-323756-atnrw9ew	195	5	,	,	,
cord-323756-atnrw9ew	195	6	like	like	IN
cord-323756-atnrw9ew	195	7	association	association	NN
cord-323756-atnrw9ew	195	8	to	to	IN
cord-323756-atnrw9ew	195	9	cellular	cellular	JJ
cord-323756-atnrw9ew	195	10	components	component	NNS
cord-323756-atnrw9ew	195	11	that	that	WDT
cord-323756-atnrw9ew	195	12	prevent	prevent	VBP
cord-323756-atnrw9ew	195	13	PRR	PRR	NNP
cord-323756-atnrw9ew	195	14	binding	binding	NN
cord-323756-atnrw9ew	195	15	,	,	,
cord-323756-atnrw9ew	195	16	or	or	CC
cord-323756-atnrw9ew	195	17	specific	specific	JJ
cord-323756-atnrw9ew	195	18	tertiary	tertiary	JJ
cord-323756-atnrw9ew	195	19	structure	structure	NN
cord-323756-atnrw9ew	195	20	such	such	JJ
cord-323756-atnrw9ew	195	21	as	as	IN
cord-323756-atnrw9ew	195	22	the	the	DT
cord-323756-atnrw9ew	195	23	eukaryotic	eukaryotic	JJ
cord-323756-atnrw9ew	196	1	mRNA	mRNA	NNP
cord-323756-atnrw9ew	196	2	closed	closed	JJ
cord-323756-atnrw9ew	196	3	loop	loop	NN
cord-323756-atnrw9ew	196	4	conformation	conformation	NN
cord-323756-atnrw9ew	196	5	(	(	-LRB-
cord-323756-atnrw9ew	196	6	99	99	CD
cord-323756-atnrw9ew	196	7	)	)	-RRB-
cord-323756-atnrw9ew	196	8	,	,	,
cord-323756-atnrw9ew	196	9	could	could	MD
cord-323756-atnrw9ew	196	10	be	be	VB
cord-323756-atnrw9ew	196	11	determinants	determinant	NNS
cord-323756-atnrw9ew	196	12	for	for	IN
cord-323756-atnrw9ew	196	13	the	the	DT
cord-323756-atnrw9ew	196	14	differentiation	differentiation	NN
cord-323756-atnrw9ew	196	15	of	of	IN
cord-323756-atnrw9ew	196	16	host	host	NN
cord-323756-atnrw9ew	196	17	mRNAs	mRNAs	NNPS
cord-323756-atnrw9ew	196	18	from	from	IN
cord-323756-atnrw9ew	196	19	microbial	microbial	JJ
cord-323756-atnrw9ew	196	20	RNAs	rna	NNS
cord-323756-atnrw9ew	196	21	.	.	.
cord-323756-atnrw9ew	197	1	Identification	identification	NN
cord-323756-atnrw9ew	197	2	of	of	IN
cord-323756-atnrw9ew	197	3	receptors	receptor	NNS
cord-323756-atnrw9ew	197	4	able	able	JJ
cord-323756-atnrw9ew	197	5	to	to	TO
cord-323756-atnrw9ew	197	6	recognize	recognize	VB
cord-323756-atnrw9ew	197	7	such	such	JJ
cord-323756-atnrw9ew	197	8	features	feature	NNS
cord-323756-atnrw9ew	197	9	are	be	VBP
cord-323756-atnrw9ew	197	10	lacking	lack	VBG
cord-323756-atnrw9ew	197	11	so	so	RB
cord-323756-atnrw9ew	197	12	far	far	RB
cord-323756-atnrw9ew	197	13	.	.	.
cord-323756-atnrw9ew	198	1	Infectious	infectious	JJ
cord-323756-atnrw9ew	198	2	microorganisms	microorganism	NNS
cord-323756-atnrw9ew	198	3	have	have	VBP
cord-323756-atnrw9ew	198	4	developed	develop	VBN
cord-323756-atnrw9ew	198	5	several	several	JJ
cord-323756-atnrw9ew	198	6	strategies	strategy	NNS
cord-323756-atnrw9ew	198	7	to	to	TO
cord-323756-atnrw9ew	198	8	evade	evade	VB
cord-323756-atnrw9ew	198	9	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	198	10	sensing	sensing	NN
cord-323756-atnrw9ew	198	11	.	.	.
cord-323756-atnrw9ew	199	1	One	one	CD
cord-323756-atnrw9ew	199	2	of	of	IN
cord-323756-atnrw9ew	199	3	these	these	DT
cord-323756-atnrw9ew	199	4	strategies	strategy	NNS
cord-323756-atnrw9ew	199	5	,	,	,
cord-323756-atnrw9ew	199	6	which	which	WDT
cord-323756-atnrw9ew	199	7	we	-PRON-	PRP
cord-323756-atnrw9ew	199	8	only	only	RB
cord-323756-atnrw9ew	199	9	mention	mention	VBP
cord-323756-atnrw9ew	199	10	briefly	briefly	RB
cord-323756-atnrw9ew	199	11	here	here	RB
cord-323756-atnrw9ew	199	12	,	,	,
cord-323756-atnrw9ew	199	13	is	be	VBZ
cord-323756-atnrw9ew	199	14	the	the	DT
cord-323756-atnrw9ew	199	15	direct	direct	JJ
cord-323756-atnrw9ew	199	16	targeting	targeting	NN
cord-323756-atnrw9ew	199	17	by	by	IN
cord-323756-atnrw9ew	199	18	microbial	microbial	JJ
cord-323756-atnrw9ew	199	19	proteins	protein	NNS
cord-323756-atnrw9ew	199	20	www.frontiersin.org	www.frontiersin.org	IN
cord-323756-atnrw9ew	199	21	 	 	_SP
cord-323756-atnrw9ew	200	1	Some	some	DT
cord-323756-atnrw9ew	201	1	(	(	-LRB-
cord-323756-atnrw9ew	201	2	−)ssRNA	−)ssRNA	``
cord-323756-atnrw9ew	201	3	viruses	virus	NNS
cord-323756-atnrw9ew	201	4	edit	edit	VBP
cord-323756-atnrw9ew	201	5	the	the	DT
cord-323756-atnrw9ew	201	6	5	5	CD
cord-323756-atnrw9ew	201	7	-ppp	-ppp	:
cord-323756-atnrw9ew	201	8	moieties	moiety	NNS
cord-323756-atnrw9ew	201	9	in	in	IN
cord-323756-atnrw9ew	201	10	their	-PRON-	PRP$
cord-323756-atnrw9ew	201	11	genomes	genome	NNS
cord-323756-atnrw9ew	201	12	as	as	RB
cord-323756-atnrw9ew	201	13	well	well	RB
cord-323756-atnrw9ew	201	14	as	as	IN
cord-323756-atnrw9ew	201	15	replication	replication	NN
cord-323756-atnrw9ew	201	16	intermediates	intermediate	NNS
cord-323756-atnrw9ew	201	17	into	into	IN
cord-323756-atnrw9ew	201	18	5	5	CD
cord-323756-atnrw9ew	201	19	mono	mono	NNS
cord-323756-atnrw9ew	201	20	-	-	HYPH
cord-323756-atnrw9ew	201	21	phosphates	phosphate	NNS
cord-323756-atnrw9ew	201	22	to	to	TO
cord-323756-atnrw9ew	201	23	avoid	avoid	VB
cord-323756-atnrw9ew	201	24	recognition	recognition	NN
cord-323756-atnrw9ew	201	25	by	by	IN
cord-323756-atnrw9ew	201	26	RLRs	rlr	NNS
cord-323756-atnrw9ew	201	27	(	(	-LRB-
cord-323756-atnrw9ew	201	28	101	101	CD
cord-323756-atnrw9ew	201	29	)	)	-RRB-
cord-323756-atnrw9ew	201	30	.	.	.
cord-323756-atnrw9ew	202	1	Arenaviruses	Arenaviruses	NNP
cord-323756-atnrw9ew	202	2	produce	produce	VBP
cord-323756-atnrw9ew	202	3	RNA	RNA	NNP
cord-323756-atnrw9ew	202	4	panhandle	panhandle	NN
cord-323756-atnrw9ew	202	5	structures	structure	NNS
cord-323756-atnrw9ew	202	6	with	with	IN
cord-323756-atnrw9ew	202	7	a	a	DT
cord-323756-atnrw9ew	202	8	5	5	CD
cord-323756-atnrw9ew	202	9	-ppp	-ppp	:
cord-323756-atnrw9ew	202	10	containing	contain	VBG
cord-323756-atnrw9ew	202	11	a	a	DT
cord-323756-atnrw9ew	202	12	GTP	GTP	NNP
cord-323756-atnrw9ew	202	13	overhanging	overhang	VBG
cord-323756-atnrw9ew	202	14	nucleotide	nucleotide	NN
cord-323756-atnrw9ew	202	15	.	.	.
cord-323756-atnrw9ew	203	1	This	this	DT
cord-323756-atnrw9ew	203	2	viral	viral	JJ
cord-323756-atnrw9ew	203	3	structure	structure	NN
cord-323756-atnrw9ew	203	4	is	be	VBZ
cord-323756-atnrw9ew	203	5	suggested	suggest	VBN
cord-323756-atnrw9ew	203	6	to	to	TO
cord-323756-atnrw9ew	203	7	act	act	VB
cord-323756-atnrw9ew	203	8	as	as	IN
cord-323756-atnrw9ew	203	9	a	a	DT
cord-323756-atnrw9ew	203	10	RIG	rig	NN
cord-323756-atnrw9ew	203	11	-	-	HYPH
cord-323756-atnrw9ew	203	12	I	i	NN
cord-323756-atnrw9ew	203	13	ligand	ligand	NN
cord-323756-atnrw9ew	203	14	decoy	decoy	NN
cord-323756-atnrw9ew	203	15	,	,	,
cord-323756-atnrw9ew	203	16	by	by	IN
cord-323756-atnrw9ew	203	17	trapping	trap	VBG
cord-323756-atnrw9ew	203	18	RIG	rig	NN
cord-323756-atnrw9ew	203	19	-	-	:
cord-323756-atnrw9ew	203	20	I	i	NN
cord-323756-atnrw9ew	203	21	but	but	CC
cord-323756-atnrw9ew	203	22	not	not	RB
cord-323756-atnrw9ew	203	23	activating	activate	VBG
cord-323756-atnrw9ew	203	24	it	-PRON-	PRP
cord-323756-atnrw9ew	203	25	(	(	-LRB-
cord-323756-atnrw9ew	203	26	102	102	CD
cord-323756-atnrw9ew	203	27	)	)	-RRB-
cord-323756-atnrw9ew	203	28	.	.	.
cord-323756-atnrw9ew	204	1	We	-PRON-	PRP
cord-323756-atnrw9ew	204	2	are	be	VBP
cord-323756-atnrw9ew	204	3	beginning	begin	VBG
cord-323756-atnrw9ew	204	4	to	to	TO
cord-323756-atnrw9ew	204	5	understand	understand	VB
cord-323756-atnrw9ew	204	6	how	how	WRB
cord-323756-atnrw9ew	204	7	eukaryotic	eukaryotic	JJ
cord-323756-atnrw9ew	204	8	cells	cell	NNS
cord-323756-atnrw9ew	204	9	use	use	VBP
cord-323756-atnrw9ew	204	10	nucleoside	nucleoside	JJ
cord-323756-atnrw9ew	204	11	modifications	modification	NNS
cord-323756-atnrw9ew	204	12	in	in	IN
cord-323756-atnrw9ew	204	13	order	order	NN
cord-323756-atnrw9ew	204	14	to	to	TO
cord-323756-atnrw9ew	204	15	protect	protect	VB
cord-323756-atnrw9ew	204	16	self	self	NN
cord-323756-atnrw9ew	204	17	-	-	HYPH
cord-323756-atnrw9ew	204	18	RNAs	rna	NNS
cord-323756-atnrw9ew	204	19	from	from	IN
cord-323756-atnrw9ew	204	20	innate	innate	JJ
cord-323756-atnrw9ew	204	21	sensing	sensing	NN
cord-323756-atnrw9ew	204	22	.	.	.
cord-323756-atnrw9ew	205	1	For	for	IN
cord-323756-atnrw9ew	205	2	example	example	NN
cord-323756-atnrw9ew	205	3	,	,	,
cord-323756-atnrw9ew	205	4	higher	high	JJR
cord-323756-atnrw9ew	205	5	eukaryotes	eukaryote	NNS
cord-323756-atnrw9ew	205	6	have	have	VBP
cord-323756-atnrw9ew	205	7	acquired	acquire	VBN
cord-323756-atnrw9ew	205	8	the	the	DT
cord-323756-atnrw9ew	205	9	ability	ability	NN
cord-323756-atnrw9ew	205	10	to	to	IN
cord-323756-atnrw9ew	205	11	2	2	CD
cord-323756-atnrw9ew	205	12	-Omethylate	-Omethylate	.
cord-323756-atnrw9ew	205	13	their	-PRON-	PRP$
cord-323756-atnrw9ew	205	14	mRNAs	mrna	NNS
cord-323756-atnrw9ew	205	15	,	,	,
cord-323756-atnrw9ew	205	16	allowing	allow	VBG
cord-323756-atnrw9ew	205	17	cellular	cellular	JJ
cord-323756-atnrw9ew	205	18	receptors	receptor	NNS
cord-323756-atnrw9ew	205	19	to	to	TO
cord-323756-atnrw9ew	205	20	distinguish	distinguish	VB
cord-323756-atnrw9ew	205	21	self	self	NN
cord-323756-atnrw9ew	205	22	from	from	IN
cord-323756-atnrw9ew	205	23	unmethylated	unmethylated	JJ
cord-323756-atnrw9ew	205	24	non	non	NNP
cord-323756-atnrw9ew	205	25	-	-	JJ
cord-323756-atnrw9ew	205	26	self	self	JJ
cord-323756-atnrw9ew	205	27	mRNA	mrna	NN
cord-323756-atnrw9ew	205	28	through	through	IN
cord-323756-atnrw9ew	205	29	specific	specific	JJ
cord-323756-atnrw9ew	205	30	types	type	NNS
cord-323756-atnrw9ew	205	31	of	of	IN
cord-323756-atnrw9ew	205	32	antiviral	antiviral	JJ
cord-323756-atnrw9ew	205	33	sensors	sensor	NNS
cord-323756-atnrw9ew	205	34	such	such	JJ
cord-323756-atnrw9ew	205	35	as	as	IN
cord-323756-atnrw9ew	205	36	MDA5	MDA5	NNP
cord-323756-atnrw9ew	205	37	and	and	CC
cord-323756-atnrw9ew	205	38	IFITs	IFITs	NNP
cord-323756-atnrw9ew	205	39	(	(	-LRB-
cord-323756-atnrw9ew	205	40	57	57	CD
cord-323756-atnrw9ew	205	41	,	,	,
cord-323756-atnrw9ew	205	42	85	85	CD
cord-323756-atnrw9ew	205	43	)	)	-RRB-
cord-323756-atnrw9ew	205	44	.	.	.
cord-323756-atnrw9ew	206	1	Consistent	consistent	JJ
cord-323756-atnrw9ew	206	2	with	with	IN
cord-323756-atnrw9ew	206	3	the	the	DT
cord-323756-atnrw9ew	206	4	red	red	JJ
cord-323756-atnrw9ew	206	5	queen	queen	NNP
cord-323756-atnrw9ew	206	6	hypothesis	hypothesis	NN
cord-323756-atnrw9ew	206	7	(	(	-LRB-
cord-323756-atnrw9ew	206	8	103	103	CD
cord-323756-atnrw9ew	206	9	)	)	-RRB-
cord-323756-atnrw9ew	206	10	,	,	,
cord-323756-atnrw9ew	206	11	which	which	WDT
cord-323756-atnrw9ew	206	12	postulates	postulate	VBZ
cord-323756-atnrw9ew	206	13	that	that	IN
cord-323756-atnrw9ew	206	14	parasites	parasite	NNS
cord-323756-atnrw9ew	206	15	have	have	VBP
cord-323756-atnrw9ew	206	16	to	to	TO
cord-323756-atnrw9ew	206	17	constantly	constantly	RB
cord-323756-atnrw9ew	206	18	evolve	evolve	VB
cord-323756-atnrw9ew	206	19	in	in	IN
cord-323756-atnrw9ew	206	20	order	order	NN
cord-323756-atnrw9ew	206	21	to	to	TO
cord-323756-atnrw9ew	206	22	adapt	adapt	VB
cord-323756-atnrw9ew	206	23	to	to	IN
cord-323756-atnrw9ew	206	24	their	-PRON-	PRP$
cord-323756-atnrw9ew	206	25	host	host	NN
cord-323756-atnrw9ew	206	26	species	specie	NNS
cord-323756-atnrw9ew	206	27	,	,	,
cord-323756-atnrw9ew	206	28	the	the	DT
cord-323756-atnrw9ew	206	29	same	same	JJ
cord-323756-atnrw9ew	206	30	immune	immune	JJ
cord-323756-atnrw9ew	206	31	escape	escape	NN
cord-323756-atnrw9ew	206	32	strategy	strategy	NN
cord-323756-atnrw9ew	206	33	has	have	VBZ
cord-323756-atnrw9ew	206	34	been	be	VBN
cord-323756-atnrw9ew	206	35	mimicked	mimic	VBN
cord-323756-atnrw9ew	206	36	by	by	IN
cord-323756-atnrw9ew	206	37	several	several	JJ
cord-323756-atnrw9ew	206	38	pathogens	pathogen	NNS
cord-323756-atnrw9ew	206	39	,	,	,
cord-323756-atnrw9ew	206	40	like	like	IN
cord-323756-atnrw9ew	206	41	flaviviruses	flavivirus	NNS
cord-323756-atnrw9ew	206	42	(	(	-LRB-
cord-323756-atnrw9ew	206	43	84	84	CD
cord-323756-atnrw9ew	206	44	,	,	,
cord-323756-atnrw9ew	206	45	86	86	CD
cord-323756-atnrw9ew	206	46	)	)	-RRB-
cord-323756-atnrw9ew	206	47	.	.	.
cord-323756-atnrw9ew	207	1	Similarly	similarly	RB
cord-323756-atnrw9ew	207	2	,	,	,
cord-323756-atnrw9ew	207	3	2	2	CD
cord-323756-atnrw9ew	207	4	-O	-O	NNS
cord-323756-atnrw9ew	207	5	-	-	HYPH
cord-323756-atnrw9ew	207	6	methylation	methylation	NN
cord-323756-atnrw9ew	207	7	of	of	IN
cord-323756-atnrw9ew	207	8	G18	G18	NNP
cord-323756-atnrw9ew	207	9	(	(	-LRB-
cord-323756-atnrw9ew	207	10	Gm18	Gm18	NNP
cord-323756-atnrw9ew	207	11	)	)	-RRB-
cord-323756-atnrw9ew	207	12	on	on	IN
cord-323756-atnrw9ew	207	13	bacterial	bacterial	JJ
cord-323756-atnrw9ew	207	14	tRNA	tRNA	NNP
cord-323756-atnrw9ew	207	15	suppresses	suppress	VBZ
cord-323756-atnrw9ew	207	16	activation	activation	NN
cord-323756-atnrw9ew	207	17	of	of	IN
cord-323756-atnrw9ew	207	18	the	the	DT
cord-323756-atnrw9ew	207	19	immune	immune	JJ
cord-323756-atnrw9ew	207	20	response	response	NN
cord-323756-atnrw9ew	207	21	in	in	IN
cord-323756-atnrw9ew	207	22	plasmacytoid	plasmacytoid	NNP
cord-323756-atnrw9ew	207	23	DCs	DCs	NNP
cord-323756-atnrw9ew	207	24	(	(	-LRB-
cord-323756-atnrw9ew	207	25	104	104	CD
cord-323756-atnrw9ew	207	26	,	,	,
cord-323756-atnrw9ew	207	27	105	105	CD
cord-323756-atnrw9ew	207	28	)	)	-RRB-
cord-323756-atnrw9ew	207	29	.	.	.
cord-323756-atnrw9ew	208	1	Flaviviruses	flavivirus	NNS
cord-323756-atnrw9ew	208	2	and	and	CC
cord-323756-atnrw9ew	208	3	other	other	JJ
cord-323756-atnrw9ew	208	4	viruses	virus	NNS
cord-323756-atnrw9ew	208	5	are	be	VBP
cord-323756-atnrw9ew	208	6	also	also	RB
cord-323756-atnrw9ew	208	7	known	know	VBN
cord-323756-atnrw9ew	208	8	to	to	TO
cord-323756-atnrw9ew	208	9	induce	induce	VB
cord-323756-atnrw9ew	208	10	cellular	cellular	JJ
cord-323756-atnrw9ew	208	11	membrane	membrane	NN
cord-323756-atnrw9ew	208	12	reorganization	reorganization	NN
cord-323756-atnrw9ew	208	13	that	that	WDT
cord-323756-atnrw9ew	208	14	allows	allow	VBZ
cord-323756-atnrw9ew	208	15	them	-PRON-	PRP
cord-323756-atnrw9ew	208	16	to	to	TO
cord-323756-atnrw9ew	208	17	replicate	replicate	VB
cord-323756-atnrw9ew	208	18	in	in	IN
cord-323756-atnrw9ew	208	19	subcellular	subcellular	JJ
cord-323756-atnrw9ew	208	20	compartments	compartment	NNS
cord-323756-atnrw9ew	208	21	,	,	,
cord-323756-atnrw9ew	208	22	creating	create	VBG
cord-323756-atnrw9ew	208	23	new	new	JJ
cord-323756-atnrw9ew	208	24	replication	replication	NN
cord-323756-atnrw9ew	208	25	-	-	HYPH
cord-323756-atnrw9ew	208	26	dependent	dependent	JJ
cord-323756-atnrw9ew	208	27	organelles	organelle	NNS
cord-323756-atnrw9ew	208	28	(	(	-LRB-
cord-323756-atnrw9ew	208	29	106	106	CD
cord-323756-atnrw9ew	208	30	)	)	-RRB-
cord-323756-atnrw9ew	208	31	.	.	.
cord-323756-atnrw9ew	209	1	Thus	thus	RB
cord-323756-atnrw9ew	209	2	,	,	,
cord-323756-atnrw9ew	209	3	tick	tick	VB
cord-323756-atnrw9ew	209	4	-	-	HYPH
cord-323756-atnrw9ew	209	5	borne	bear	VBN
cord-323756-atnrw9ew	209	6	encephalitis	encephalitis	JJ
cord-323756-atnrw9ew	209	7	virus	virus	NN
cord-323756-atnrw9ew	209	8	or	or	CC
cord-323756-atnrw9ew	209	9	Japanese	japanese	JJ
cord-323756-atnrw9ew	209	10	encephalitis	encephalitis	NN
cord-323756-atnrw9ew	209	11	virus	virus	NN
cord-323756-atnrw9ew	209	12	have	have	VBP
cord-323756-atnrw9ew	209	13	been	be	VBN
cord-323756-atnrw9ew	209	14	shown	show	VBN
cord-323756-atnrw9ew	209	15	to	to	TO
cord-323756-atnrw9ew	209	16	rearrange	rearrange	VB
cord-323756-atnrw9ew	209	17	endoplasmic	endoplasmic	NN
cord-323756-atnrw9ew	209	18	reticulum	reticulum	NN
cord-323756-atnrw9ew	209	19	membranes	membrane	NNS
cord-323756-atnrw9ew	209	20	to	to	TO
cord-323756-atnrw9ew	209	21	provide	provide	VB
cord-323756-atnrw9ew	209	22	a	a	DT
cord-323756-atnrw9ew	209	23	compartment	compartment	NN
cord-323756-atnrw9ew	209	24	where	where	WRB
cord-323756-atnrw9ew	209	25	viral	viral	JJ
cord-323756-atnrw9ew	209	26	dsRNA	dsrna	NN
cord-323756-atnrw9ew	209	27	is	be	VBZ
cord-323756-atnrw9ew	209	28	concealed	conceal	VBN
cord-323756-atnrw9ew	209	29	from	from	IN
cord-323756-atnrw9ew	209	30	PRR	PRR	NNP
cord-323756-atnrw9ew	209	31	recognition	recognition	NN
cord-323756-atnrw9ew	209	32	.	.	.
cord-323756-atnrw9ew	210	1	This	this	DT
cord-323756-atnrw9ew	210	2	hijacking	hijacking	NN
cord-323756-atnrw9ew	210	3	of	of	IN
cord-323756-atnrw9ew	210	4	internal	internal	JJ
cord-323756-atnrw9ew	210	5	cell	cell	NN
cord-323756-atnrw9ew	210	6	membrane	membrane	NN
cord-323756-atnrw9ew	210	7	induces	induce	VBZ
cord-323756-atnrw9ew	210	8	a	a	DT
cord-323756-atnrw9ew	210	9	delayed	delay	VBN
cord-323756-atnrw9ew	210	10	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	210	11	exposure	exposure	NN
cord-323756-atnrw9ew	210	12	of	of	IN
cord-323756-atnrw9ew	210	13	viral	viral	JJ
cord-323756-atnrw9ew	210	14	RNA	RNA	NNP
cord-323756-atnrw9ew	210	15	to	to	TO
cord-323756-atnrw9ew	210	16	innate	innate	VB
cord-323756-atnrw9ew	210	17	receptors	receptor	NNS
cord-323756-atnrw9ew	210	18	and	and	CC
cord-323756-atnrw9ew	210	19	accordingly	accordingly	RB
cord-323756-atnrw9ew	210	20	,	,	,
cord-323756-atnrw9ew	210	21	IFN	IFN	NNP
cord-323756-atnrw9ew	210	22	-	-	HYPH
cord-323756-atnrw9ew	210	23	I	-PRON-	PRP
cord-323756-atnrw9ew	210	24	responses	response	NNS
cord-323756-atnrw9ew	210	25	are	be	VBP
cord-323756-atnrw9ew	210	26	only	only	RB
cord-323756-atnrw9ew	210	27	measured	measure	VBN
cord-323756-atnrw9ew	210	28	late	late	RB
cord-323756-atnrw9ew	210	29	in	in	IN
cord-323756-atnrw9ew	210	30	the	the	DT
cord-323756-atnrw9ew	210	31	replication	replication	NN
cord-323756-atnrw9ew	210	32	cycle	cycle	NN
cord-323756-atnrw9ew	210	33	(	(	-LRB-
cord-323756-atnrw9ew	210	34	107	107	CD
cord-323756-atnrw9ew	210	35	)	)	-RRB-
cord-323756-atnrw9ew	210	36	(	(	-LRB-
cord-323756-atnrw9ew	210	37	108	108	CD
cord-323756-atnrw9ew	210	38	)	)	-RRB-
cord-323756-atnrw9ew	210	39	(	(	-LRB-
cord-323756-atnrw9ew	210	40	109	109	CD
cord-323756-atnrw9ew	210	41	)	)	-RRB-
cord-323756-atnrw9ew	210	42	.	.	.
cord-323756-atnrw9ew	211	1	The	the	DT
cord-323756-atnrw9ew	211	2	NS1	ns1	NN
cord-323756-atnrw9ew	211	3	protein	protein	NN
cord-323756-atnrw9ew	211	4	from	from	IN
cord-323756-atnrw9ew	211	5	influenza	influenza	NN
cord-323756-atnrw9ew	211	6	virus	virus	NN
cord-323756-atnrw9ew	211	7	can	can	MD
cord-323756-atnrw9ew	211	8	prevent	prevent	VB
cord-323756-atnrw9ew	211	9	RNA	RNA	NNP
cord-323756-atnrw9ew	211	10	sensing	sensing	NN
cord-323756-atnrw9ew	211	11	through	through	IN
cord-323756-atnrw9ew	211	12	the	the	DT
cord-323756-atnrw9ew	211	13	formation	formation	NN
cord-323756-atnrw9ew	211	14	of	of	IN
cord-323756-atnrw9ew	211	15	a	a	DT
cord-323756-atnrw9ew	211	16	chain	chain	NN
cord-323756-atnrw9ew	211	17	of	of	IN
cord-323756-atnrw9ew	211	18	NS1	ns1	NN
cord-323756-atnrw9ew	211	19	molecules	molecule	NNS
cord-323756-atnrw9ew	211	20	along	along	IN
cord-323756-atnrw9ew	211	21	the	the	DT
cord-323756-atnrw9ew	211	22	influenza	influenza	NN
cord-323756-atnrw9ew	211	23	dsRNA	dsrna	CD
cord-323756-atnrw9ew	211	24	backbone	backbone	NN
cord-323756-atnrw9ew	211	25	(	(	-LRB-
cord-323756-atnrw9ew	211	26	110	110	CD
cord-323756-atnrw9ew	211	27	)	)	-RRB-
cord-323756-atnrw9ew	211	28	.	.	.
cord-323756-atnrw9ew	212	1	Picornaviruses	Picornaviruses	NNP
cord-323756-atnrw9ew	212	2	mask	mask	VBP
cord-323756-atnrw9ew	212	3	their	-PRON-	PRP$
cord-323756-atnrw9ew	212	4	5ppp	5ppp	CD
cord-323756-atnrw9ew	212	5	with	with	IN
cord-323756-atnrw9ew	212	6	a	a	DT
cord-323756-atnrw9ew	212	7	viral	viral	JJ
cord-323756-atnrw9ew	212	8	encoded	encode	VBN
cord-323756-atnrw9ew	212	9	protein	protein	NN
cord-323756-atnrw9ew	212	10	,	,	,
cord-323756-atnrw9ew	212	11	VPg	VPg	NNS
cord-323756-atnrw9ew	212	12	,	,	,
cord-323756-atnrw9ew	212	13	which	which	WDT
cord-323756-atnrw9ew	212	14	functions	function	VBZ
cord-323756-atnrw9ew	212	15	as	as	IN
cord-323756-atnrw9ew	212	16	a	a	DT
cord-323756-atnrw9ew	212	17	5	5	CD
cord-323756-atnrw9ew	212	18	cap	cap	NN
cord-323756-atnrw9ew	212	19	and	and	CC
cord-323756-atnrw9ew	212	20	as	as	IN
cord-323756-atnrw9ew	212	21	a	a	DT
cord-323756-atnrw9ew	212	22	primer	primer	NN
cord-323756-atnrw9ew	212	23	during	during	IN
cord-323756-atnrw9ew	212	24	RNA	RNA	NNP
cord-323756-atnrw9ew	212	25	synthesis	synthesis	NN
cord-323756-atnrw9ew	212	26	.	.	.
cord-323756-atnrw9ew	213	1	Interestingly	interestingly	RB
cord-323756-atnrw9ew	213	2	,	,	,
cord-323756-atnrw9ew	213	3	studies	study	NNS
cord-323756-atnrw9ew	213	4	have	have	VBP
cord-323756-atnrw9ew	213	5	shown	show	VBN
cord-323756-atnrw9ew	213	6	that	that	IN
cord-323756-atnrw9ew	213	7	VPg	VPg	NNS
cord-323756-atnrw9ew	213	8	could	could	MD
cord-323756-atnrw9ew	213	9	be	be	VB
cord-323756-atnrw9ew	213	10	used	use	VBN
cord-323756-atnrw9ew	213	11	to	to	TO
cord-323756-atnrw9ew	213	12	evade	evade	VB
cord-323756-atnrw9ew	213	13	RIG	rig	NN
cord-323756-atnrw9ew	213	14	-	-	:
cord-323756-atnrw9ew	213	15	I	i	NN
cord-323756-atnrw9ew	213	16	recognition	recognition	NN
cord-323756-atnrw9ew	213	17	(	(	-LRB-
cord-323756-atnrw9ew	213	18	111	111	CD
cord-323756-atnrw9ew	213	19	)	)	-RRB-
cord-323756-atnrw9ew	213	20	.	.	.
cord-323756-atnrw9ew	214	1	Similarly	similarly	RB
cord-323756-atnrw9ew	214	2	,	,	,
cord-323756-atnrw9ew	214	3	Ebola	Ebola	NNP
cord-323756-atnrw9ew	214	4	virus	virus	NN
cord-323756-atnrw9ew	214	5	VP35	VP35	NNP
cord-323756-atnrw9ew	214	6	assembles	assemble	VBZ
cord-323756-atnrw9ew	214	7	into	into	IN
cord-323756-atnrw9ew	214	8	dimmers	dimmer	NNS
cord-323756-atnrw9ew	214	9	to	to	TO
cord-323756-atnrw9ew	214	10	cap	cap	VB
cord-323756-atnrw9ew	214	11	the	the	DT
cord-323756-atnrw9ew	214	12	ends	end	NNS
cord-323756-atnrw9ew	214	13	of	of	IN
cord-323756-atnrw9ew	214	14	viral	viral	JJ
cord-323756-atnrw9ew	214	15	dsRNA	dsrna	NN
cord-323756-atnrw9ew	214	16	and	and	CC
cord-323756-atnrw9ew	214	17	hide	hide	VB
cord-323756-atnrw9ew	214	18	the	the	DT
cord-323756-atnrw9ew	214	19	specific	specific	JJ
cord-323756-atnrw9ew	214	20	RIG	rig	NN
cord-323756-atnrw9ew	214	21	-	-	:
cord-323756-atnrw9ew	214	22	I	i	NN
cord-323756-atnrw9ew	214	23	recognition	recognition	NN
cord-323756-atnrw9ew	214	24	site	site	NN
cord-323756-atnrw9ew	214	25	(	(	-LRB-
cord-323756-atnrw9ew	214	26	112	112	CD
cord-323756-atnrw9ew	214	27	)	)	-RRB-
cord-323756-atnrw9ew	214	28	.	.	.
cord-323756-atnrw9ew	215	1	While	while	IN
cord-323756-atnrw9ew	215	2	one	one	CD
cord-323756-atnrw9ew	215	3	VP35	VP35	NNP
cord-323756-atnrw9ew	215	4	monomer	monomer	NN
cord-323756-atnrw9ew	215	5	binds	bind	VBZ
cord-323756-atnrw9ew	215	6	the	the	DT
cord-323756-atnrw9ew	215	7	terminus	terminus	NN
cord-323756-atnrw9ew	215	8	and	and	CC
cord-323756-atnrw9ew	215	9	backbone	backbone	NN
cord-323756-atnrw9ew	215	10	of	of	IN
cord-323756-atnrw9ew	215	11	dsRNA	dsrna	NN
cord-323756-atnrw9ew	215	12	,	,	,
cord-323756-atnrw9ew	215	13	the	the	DT
cord-323756-atnrw9ew	215	14	other	other	JJ
cord-323756-atnrw9ew	215	15	VP35	VP35	NNP
cord-323756-atnrw9ew	215	16	monomer	monomer	NN
cord-323756-atnrw9ew	215	17	binds	bind	VBZ
cord-323756-atnrw9ew	215	18	only	only	RB
cord-323756-atnrw9ew	215	19	the	the	DT
cord-323756-atnrw9ew	215	20	phosphate	phosphate	NN
cord-323756-atnrw9ew	215	21	backbone	backbone	NN
cord-323756-atnrw9ew	215	22	of	of	IN
cord-323756-atnrw9ew	215	23	the	the	DT
cord-323756-atnrw9ew	215	24	dsRNA	dsrna	NN
cord-323756-atnrw9ew	215	25	,	,	,
cord-323756-atnrw9ew	215	26	displaying	display	VBG
cord-323756-atnrw9ew	215	27	a	a	DT
cord-323756-atnrw9ew	215	28	unique	unique	JJ
cord-323756-atnrw9ew	215	29	mode	mode	NN
cord-323756-atnrw9ew	215	30	of	of	IN
cord-323756-atnrw9ew	215	31	dsRNA	dsrna	NN
cord-323756-atnrw9ew	215	32	concealing	conceal	VBG
cord-323756-atnrw9ew	215	33	from	from	IN
cord-323756-atnrw9ew	215	34	PRR	PRR	NNP
cord-323756-atnrw9ew	215	35	(	(	-LRB-
cord-323756-atnrw9ew	215	36	112	112	CD
cord-323756-atnrw9ew	215	37	)	)	-RRB-
cord-323756-atnrw9ew	215	38	.	.	.
cord-323756-atnrw9ew	216	1	Another	another	DT
cord-323756-atnrw9ew	216	2	hemorrhagic	hemorrhagic	JJ
cord-323756-atnrw9ew	216	3	fever	fever	NN
cord-323756-atnrw9ew	216	4	virus	virus	NN
cord-323756-atnrw9ew	216	5	,	,	,
cord-323756-atnrw9ew	216	6	Lassa	Lassa	NNP
cord-323756-atnrw9ew	216	7	fever	fever	NN
cord-323756-atnrw9ew	216	8	virus	virus	NN
cord-323756-atnrw9ew	216	9	,	,	,
cord-323756-atnrw9ew	216	10	uses	use	VBZ
cord-323756-atnrw9ew	216	11	the	the	DT
cord-323756-atnrw9ew	216	12	3'-5	3'-5	NNP
cord-323756-atnrw9ew	216	13	'	'	POS
cord-323756-atnrw9ew	216	14	exonuclease	exonuclease	NN
cord-323756-atnrw9ew	216	15	activity	activity	NN
cord-323756-atnrw9ew	216	16	of	of	IN
cord-323756-atnrw9ew	216	17	its	-PRON-	PRP$
cord-323756-atnrw9ew	216	18	nucleoprotein	nucleoprotein	NNP
cord-323756-atnrw9ew	216	19	(	(	-LRB-
cord-323756-atnrw9ew	216	20	NP	NP	NNP
cord-323756-atnrw9ew	216	21	)	)	-RRB-
cord-323756-atnrw9ew	216	22	to	to	TO
cord-323756-atnrw9ew	216	23	degrade	degrade	VB
cord-323756-atnrw9ew	216	24	stimulatory	stimulatory	JJ
cord-323756-atnrw9ew	216	25	dsRNA	dsRNA	NNS
cord-323756-atnrw9ew	216	26	(	(	-LRB-
cord-323756-atnrw9ew	216	27	113	113	CD
cord-323756-atnrw9ew	216	28	)	)	-RRB-
cord-323756-atnrw9ew	216	29	.	.	.
cord-323756-atnrw9ew	217	1	This	this	DT
cord-323756-atnrw9ew	217	2	activity	activity	NN
cord-323756-atnrw9ew	217	3	seems	seem	VBZ
cord-323756-atnrw9ew	217	4	to	to	TO
cord-323756-atnrw9ew	217	5	be	be	VB
cord-323756-atnrw9ew	217	6	shared	share	VBN
cord-323756-atnrw9ew	217	7	by	by	IN
cord-323756-atnrw9ew	217	8	other	other	JJ
cord-323756-atnrw9ew	217	9	arenaviruses	arenavirus	NNS
cord-323756-atnrw9ew	217	10	(	(	-LRB-
cord-323756-atnrw9ew	217	11	114	114	CD
cord-323756-atnrw9ew	217	12	)	)	-RRB-
cord-323756-atnrw9ew	217	13	.	.	.
cord-323756-atnrw9ew	218	1	Finally	finally	RB
cord-323756-atnrw9ew	218	2	,	,	,
cord-323756-atnrw9ew	218	3	the	the	DT
cord-323756-atnrw9ew	218	4	protein	protein	NN
cord-323756-atnrw9ew	218	5	C	C	NNP
cord-323756-atnrw9ew	218	6	from	from	IN
cord-323756-atnrw9ew	218	7	human	human	JJ
cord-323756-atnrw9ew	218	8	parainfluenza	parainfluenza	NNP
cord-323756-atnrw9ew	218	9	virus	virus	NNP
cord-323756-atnrw9ew	218	10	type	type	NNP
cord-323756-atnrw9ew	218	11	1	1	CD
cord-323756-atnrw9ew	218	12	(	(	-LRB-
cord-323756-atnrw9ew	218	13	HPIV1	HPIV1	NNP
cord-323756-atnrw9ew	218	14	)	)	-RRB-
cord-323756-atnrw9ew	218	15	,	,	,
cord-323756-atnrw9ew	218	16	a	a	DT
cord-323756-atnrw9ew	218	17	paramyxoviridae	paramyxoviridae	NN
cord-323756-atnrw9ew	218	18	,	,	,
cord-323756-atnrw9ew	218	19	has	have	VBZ
cord-323756-atnrw9ew	218	20	been	be	VBN
cord-323756-atnrw9ew	218	21	shown	show	VBN
cord-323756-atnrw9ew	218	22	to	to	TO
cord-323756-atnrw9ew	218	23	limit	limit	VB
cord-323756-atnrw9ew	218	24	the	the	DT
cord-323756-atnrw9ew	218	25	accumulation	accumulation	NN
cord-323756-atnrw9ew	218	26	of	of	IN
cord-323756-atnrw9ew	218	27	dsRNA	dsrna	NN
cord-323756-atnrw9ew	218	28	.	.	.
cord-323756-atnrw9ew	219	1	Cell	cell	NN
cord-323756-atnrw9ew	219	2	infection	infection	NN
cord-323756-atnrw9ew	219	3	by	by	IN
cord-323756-atnrw9ew	219	4	a	a	DT
cord-323756-atnrw9ew	219	5	virus	virus	NN
cord-323756-atnrw9ew	219	6	mutant	mutant	NN
cord-323756-atnrw9ew	219	7	defective	defective	JJ
cord-323756-atnrw9ew	219	8	for	for	IN
cord-323756-atnrw9ew	219	9	the	the	DT
cord-323756-atnrw9ew	219	10	C	C	NNP
cord-323756-atnrw9ew	219	11	protein	protein	NN
cord-323756-atnrw9ew	219	12	displays	display	VBZ
cord-323756-atnrw9ew	219	13	higher	high	JJR
cord-323756-atnrw9ew	219	14	accumulation	accumulation	NN
cord-323756-atnrw9ew	219	15	of	of	IN
cord-323756-atnrw9ew	219	16	several	several	JJ
cord-323756-atnrw9ew	219	17	viral	viral	JJ
cord-323756-atnrw9ew	219	18	RNAs	rna	NNS
cord-323756-atnrw9ew	219	19	,	,	,
cord-323756-atnrw9ew	219	20	including	include	VBG
cord-323756-atnrw9ew	219	21	viral	viral	JJ
cord-323756-atnrw9ew	219	22	genome	genome	NN
cord-323756-atnrw9ew	219	23	,	,	,
cord-323756-atnrw9ew	219	24	antigenome	antigenome	NNP
cord-323756-atnrw9ew	219	25	,	,	,
cord-323756-atnrw9ew	219	26	and	and	CC
cord-323756-atnrw9ew	219	27	mRNA	mrna	NN
cord-323756-atnrw9ew	219	28	,	,	,
cord-323756-atnrw9ew	219	29	eventually	eventually	RB
cord-323756-atnrw9ew	219	30	leading	lead	VBG
cord-323756-atnrw9ew	219	31	to	to	IN
cord-323756-atnrw9ew	219	32	the	the	DT
cord-323756-atnrw9ew	219	33	accumulation	accumulation	NN
cord-323756-atnrw9ew	219	34	of	of	IN
cord-323756-atnrw9ew	219	35	dsRNA	dsrna	NN
cord-323756-atnrw9ew	219	36	.	.	.
cord-323756-atnrw9ew	220	1	Thus	thus	RB
cord-323756-atnrw9ew	220	2	,	,	,
cord-323756-atnrw9ew	220	3	by	by	IN
cord-323756-atnrw9ew	220	4	limiting	limit	VBG
cord-323756-atnrw9ew	220	5	intracytosolic	intracytosolic	JJ
cord-323756-atnrw9ew	220	6	quantities	quantity	NNS
cord-323756-atnrw9ew	220	7	of	of	IN
cord-323756-atnrw9ew	220	8	viral	viral	JJ
cord-323756-atnrw9ew	220	9	dsRNA	dsrna	NN
cord-323756-atnrw9ew	220	10	,	,	,
cord-323756-atnrw9ew	220	11	the	the	DT
cord-323756-atnrw9ew	220	12	C	C	NNP
cord-323756-atnrw9ew	220	13	protein	protein	NN
cord-323756-atnrw9ew	220	14	of	of	IN
cord-323756-atnrw9ew	220	15	HPIV1	HPIV1	NNP
cord-323756-atnrw9ew	220	16	avoids	avoid	VBZ
cord-323756-atnrw9ew	220	17	dsRNA	dsRNA	VBG
cord-323756-atnrw9ew	220	18	triggering	trigger	VBG
cord-323756-atnrw9ew	220	19	of	of	IN
cord-323756-atnrw9ew	220	20	MDA5	MDA5	NNP
cord-323756-atnrw9ew	220	21	and	and	CC
cord-323756-atnrw9ew	220	22	PKR	PKR	NNP
cord-323756-atnrw9ew	220	23	in	in	IN
cord-323756-atnrw9ew	220	24	infected	infected	JJ
cord-323756-atnrw9ew	220	25	cells	cell	NNS
cord-323756-atnrw9ew	220	26	(	(	-LRB-
cord-323756-atnrw9ew	220	27	115	115	CD
cord-323756-atnrw9ew	220	28	)	)	-RRB-
cord-323756-atnrw9ew	220	29	.	.	.
cord-323756-atnrw9ew	221	1	The	the	DT
cord-323756-atnrw9ew	221	2	multiplicity	multiplicity	NN
cord-323756-atnrw9ew	221	3	of	of	IN
cord-323756-atnrw9ew	221	4	PRR	PRR	NNP
cord-323756-atnrw9ew	221	5	pathways	pathway	NNS
cord-323756-atnrw9ew	221	6	is	be	VBZ
cord-323756-atnrw9ew	221	7	an	an	DT
cord-323756-atnrw9ew	221	8	essential	essential	JJ
cord-323756-atnrw9ew	221	9	determinant	determinant	NN
cord-323756-atnrw9ew	221	10	of	of	IN
cord-323756-atnrw9ew	221	11	the	the	DT
cord-323756-atnrw9ew	221	12	immune	immune	JJ
cord-323756-atnrw9ew	221	13	system	system	NN
cord-323756-atnrw9ew	221	14	's	's	POS
cord-323756-atnrw9ew	221	15	ability	ability	NN
cord-323756-atnrw9ew	221	16	to	to	TO
cord-323756-atnrw9ew	221	17	sense	sense	VB
cord-323756-atnrw9ew	221	18	with	with	IN
cord-323756-atnrw9ew	221	19	precision	precision	NN
cord-323756-atnrw9ew	221	20	the	the	DT
cord-323756-atnrw9ew	221	21	level	level	NN
cord-323756-atnrw9ew	221	22	of	of	IN
cord-323756-atnrw9ew	221	23	Frontiers	Frontiers	NNPS
cord-323756-atnrw9ew	221	24	in	in	IN
cord-323756-atnrw9ew	221	25	Immunology	Immunology	NNP
cord-323756-atnrw9ew	221	26	|	|	NNP
cord-323756-atnrw9ew	222	1	Molecular	molecular	JJ
cord-323756-atnrw9ew	222	2	Innate	Innate	NNP
cord-323756-atnrw9ew	222	3	Immunity	Immunity	NNP
cord-323756-atnrw9ew	222	4	microbial	microbial	JJ
cord-323756-atnrw9ew	222	5	threat	threat	NN
cord-323756-atnrw9ew	222	6	and	and	CC
cord-323756-atnrw9ew	222	7	to	to	TO
cord-323756-atnrw9ew	222	8	respond	respond	VB
cord-323756-atnrw9ew	222	9	accordingly	accordingly	RB
cord-323756-atnrw9ew	222	10	(	(	-LRB-
cord-323756-atnrw9ew	222	11	4	4	CD
cord-323756-atnrw9ew	222	12	)	)	-RRB-
cord-323756-atnrw9ew	222	13	.	.	.
cord-323756-atnrw9ew	223	1	However	however	RB
cord-323756-atnrw9ew	223	2	,	,	,
cord-323756-atnrw9ew	223	3	as	as	RB
cord-323756-atnrw9ew	223	4	far	far	RB
cord-323756-atnrw9ew	223	5	as	as	IN
cord-323756-atnrw9ew	223	6	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	223	7	RNA	RNA	NNP
cord-323756-atnrw9ew	223	8	sensors	sensor	NNS
cord-323756-atnrw9ew	223	9	are	be	VBP
cord-323756-atnrw9ew	223	10	concerned	concern	VBN
cord-323756-atnrw9ew	223	11	,	,	,
cord-323756-atnrw9ew	223	12	it	-PRON-	PRP
cord-323756-atnrw9ew	223	13	is	be	VBZ
cord-323756-atnrw9ew	223	14	striking	strike	VBG
cord-323756-atnrw9ew	223	15	to	to	TO
cord-323756-atnrw9ew	223	16	observe	observe	VB
cord-323756-atnrw9ew	223	17	the	the	DT
cord-323756-atnrw9ew	223	18	contrast	contrast	NN
cord-323756-atnrw9ew	223	19	between	between	IN
cord-323756-atnrw9ew	223	20	the	the	DT
cord-323756-atnrw9ew	223	21	high	high	JJ
cord-323756-atnrw9ew	223	22	number	number	NN
cord-323756-atnrw9ew	223	23	of	of	IN
cord-323756-atnrw9ew	223	24	PRRs	prr	NNS
cord-323756-atnrw9ew	223	25	that	that	WDT
cord-323756-atnrw9ew	223	26	have	have	VBP
cord-323756-atnrw9ew	223	27	been	be	VBN
cord-323756-atnrw9ew	223	28	isolated	isolate	VBN
cord-323756-atnrw9ew	223	29	and	and	CC
cord-323756-atnrw9ew	223	30	the	the	DT
cord-323756-atnrw9ew	223	31	similarities	similarity	NNS
cord-323756-atnrw9ew	223	32	of	of	IN
cord-323756-atnrw9ew	223	33	the	the	DT
cord-323756-atnrw9ew	223	34	PAMPs	pamp	NNS
cord-323756-atnrw9ew	223	35	they	-PRON-	PRP
cord-323756-atnrw9ew	223	36	recognize	recognize	VBP
cord-323756-atnrw9ew	223	37	(	(	-LRB-
cord-323756-atnrw9ew	223	38	Table	table	NN
cord-323756-atnrw9ew	223	39	1	1	CD
cord-323756-atnrw9ew	223	40	)	)	-RRB-
cord-323756-atnrw9ew	223	41	.	.	.
cord-323756-atnrw9ew	224	1	While	while	IN
cord-323756-atnrw9ew	224	2	5	5	CD
cord-323756-atnrw9ew	224	3	-ppp	-ppp	:
cord-323756-atnrw9ew	224	4	and	and	CC
cord-323756-atnrw9ew	224	5	dsRNA	dsRNA	NNS
cord-323756-atnrw9ew	224	6	are	be	VBP
cord-323756-atnrw9ew	224	7	undoubtedly	undoubtedly	RB
cord-323756-atnrw9ew	224	8	powerful	powerful	JJ
cord-323756-atnrw9ew	224	9	triggers	trigger	NNS
cord-323756-atnrw9ew	224	10	of	of	IN
cord-323756-atnrw9ew	224	11	the	the	DT
cord-323756-atnrw9ew	224	12	innate	innate	JJ
cord-323756-atnrw9ew	224	13	immunity	immunity	NN
cord-323756-atnrw9ew	224	14	,	,	,
cord-323756-atnrw9ew	224	15	they	-PRON-	PRP
cord-323756-atnrw9ew	224	16	can	can	MD
cord-323756-atnrw9ew	224	17	not	not	RB
cord-323756-atnrw9ew	224	18	account	account	VB
cord-323756-atnrw9ew	224	19	for	for	IN
cord-323756-atnrw9ew	224	20	the	the	DT
cord-323756-atnrw9ew	224	21	diversity	diversity	NN
cord-323756-atnrw9ew	224	22	of	of	IN
cord-323756-atnrw9ew	224	23	responses	response	NNS
cord-323756-atnrw9ew	224	24	that	that	WDT
cord-323756-atnrw9ew	224	25	the	the	DT
cord-323756-atnrw9ew	224	26	organism	organism	NN
cord-323756-atnrw9ew	224	27	is	be	VBZ
cord-323756-atnrw9ew	224	28	able	able	JJ
cord-323756-atnrw9ew	224	29	to	to	TO
cord-323756-atnrw9ew	224	30	elicit	elicit	VB
cord-323756-atnrw9ew	224	31	against	against	IN
cord-323756-atnrw9ew	224	32	a	a	DT
cord-323756-atnrw9ew	224	33	wide	wide	JJ
cord-323756-atnrw9ew	224	34	range	range	NN
cord-323756-atnrw9ew	224	35	of	of	IN
cord-323756-atnrw9ew	224	36	pathogens	pathogen	NNS
cord-323756-atnrw9ew	224	37	.	.	.
cord-323756-atnrw9ew	225	1	Our	-PRON-	PRP$
cord-323756-atnrw9ew	225	2	understanding	understanding	NN
cord-323756-atnrw9ew	225	3	of	of	IN
cord-323756-atnrw9ew	225	4	how	how	WRB
cord-323756-atnrw9ew	225	5	the	the	DT
cord-323756-atnrw9ew	225	6	immune	immune	JJ
cord-323756-atnrw9ew	225	7	system	system	NN
cord-323756-atnrw9ew	225	8	distinguishes	distinguish	VBZ
cord-323756-atnrw9ew	225	9	between	between	IN
cord-323756-atnrw9ew	225	10	foreign	foreign	JJ
cord-323756-atnrw9ew	225	11	and	and	CC
cord-323756-atnrw9ew	225	12	self	self	NN
cord-323756-atnrw9ew	225	13	-	-	HYPH
cord-323756-atnrw9ew	225	14	nucleic	nucleic	JJ
cord-323756-atnrw9ew	225	15	acids	acid	NNS
cord-323756-atnrw9ew	225	16	will	will	MD
cord-323756-atnrw9ew	225	17	continue	continue	VB
cord-323756-atnrw9ew	225	18	to	to	TO
cord-323756-atnrw9ew	225	19	improve	improve	VB
cord-323756-atnrw9ew	225	20	over	over	IN
cord-323756-atnrw9ew	225	21	time	time	NN
cord-323756-atnrw9ew	225	22	.	.	.
cord-323756-atnrw9ew	226	1	This	this	DT
cord-323756-atnrw9ew	226	2	will	will	MD
cord-323756-atnrw9ew	226	3	help	help	VB
cord-323756-atnrw9ew	226	4	us	-PRON-	PRP
cord-323756-atnrw9ew	226	5	better	better	RB
cord-323756-atnrw9ew	226	6	define	define	VB
cord-323756-atnrw9ew	226	7	the	the	DT
cord-323756-atnrw9ew	226	8	precise	precise	JJ
cord-323756-atnrw9ew	226	9	role	role	NN
cord-323756-atnrw9ew	226	10	played	play	VBN
cord-323756-atnrw9ew	226	11	by	by	IN
cord-323756-atnrw9ew	226	12	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	226	13	RNA	RNA	NNP
cord-323756-atnrw9ew	226	14	sensors	sensor	NNS
cord-323756-atnrw9ew	226	15	in	in	IN
cord-323756-atnrw9ew	226	16	the	the	DT
cord-323756-atnrw9ew	226	17	global	global	JJ
cord-323756-atnrw9ew	226	18	immune	immune	JJ
cord-323756-atnrw9ew	226	19	response	response	NN
cord-323756-atnrw9ew	226	20	against	against	IN
cord-323756-atnrw9ew	226	21	pathogens	pathogen	NNS
cord-323756-atnrw9ew	226	22	.	.	.
cord-323756-atnrw9ew	227	1	Approaching	approach	VBG
cord-323756-atnrw9ew	227	2	the	the	DT
cord-323756-atnrw9ew	227	3	asymptote	asymptote	NN
cord-323756-atnrw9ew	227	4	?	?	.
cord-323756-atnrw9ew	228	1	Evolution	evolution	NN
cord-323756-atnrw9ew	228	2	and	and	CC
cord-323756-atnrw9ew	228	3	revolution	revolution	NN
cord-323756-atnrw9ew	228	4	in	in	IN
cord-323756-atnrw9ew	228	5	immunology	immunology	NN
cord-323756-atnrw9ew	229	1	A	a	DT
cord-323756-atnrw9ew	229	2	human	human	JJ
cord-323756-atnrw9ew	229	3	homologue	homologue	NN
cord-323756-atnrw9ew	229	4	of	of	IN
cord-323756-atnrw9ew	229	5	the	the	DT
cord-323756-atnrw9ew	229	6	Drosophila	Drosophila	NNP
cord-323756-atnrw9ew	229	7	toll	toll	NN
cord-323756-atnrw9ew	229	8	protein	protein	NN
cord-323756-atnrw9ew	229	9	signals	signal	VBZ
cord-323756-atnrw9ew	229	10	activation	activation	NN
cord-323756-atnrw9ew	229	11	of	of	IN
cord-323756-atnrw9ew	229	12	adaptive	adaptive	JJ
cord-323756-atnrw9ew	229	13	immunity	immunity	NN
cord-323756-atnrw9ew	229	14	Approaching	approach	VBG
cord-323756-atnrw9ew	229	15	the	the	DT
cord-323756-atnrw9ew	229	16	asymptote	asymptote	NN
cord-323756-atnrw9ew	229	17	:	:	:
cord-323756-atnrw9ew	229	18	20	20	CD
cord-323756-atnrw9ew	229	19	years	year	NNS
cord-323756-atnrw9ew	229	20	later	later	RB
cord-323756-atnrw9ew	230	1	Beyond	beyond	IN
cord-323756-atnrw9ew	230	2	pattern	pattern	NN
cord-323756-atnrw9ew	230	3	recognition	recognition	NN
cord-323756-atnrw9ew	230	4	:	:	:
cord-323756-atnrw9ew	230	5	five	five	CD
cord-323756-atnrw9ew	230	6	immune	immune	JJ
cord-323756-atnrw9ew	230	7	checkpoints	checkpoint	NNS
cord-323756-atnrw9ew	230	8	for	for	IN
cord-323756-atnrw9ew	230	9	scaling	scale	VBG
cord-323756-atnrw9ew	230	10	the	the	DT
cord-323756-atnrw9ew	230	11	microbial	microbial	JJ
cord-323756-atnrw9ew	230	12	threat	threat	NN
cord-323756-atnrw9ew	230	13	Activation	activation	NN
cord-323756-atnrw9ew	230	14	of	of	IN
cord-323756-atnrw9ew	230	15	target	target	NN
cord-323756-atnrw9ew	230	16	-	-	HYPH
cord-323756-atnrw9ew	230	17	tissue	tissue	NN
cord-323756-atnrw9ew	230	18	immune	immune	JJ
cord-323756-atnrw9ew	230	19	-	-	HYPH
cord-323756-atnrw9ew	230	20	recognition	recognition	NN
cord-323756-atnrw9ew	230	21	molecules	molecule	NNS
cord-323756-atnrw9ew	230	22	by	by	IN
cord-323756-atnrw9ew	230	23	double	double	RB
cord-323756-atnrw9ew	230	24	-	-	HYPH
cord-323756-atnrw9ew	230	25	stranded	strand	VBN
cord-323756-atnrw9ew	230	26	polynucleotides	polynucleotide	NNS
cord-323756-atnrw9ew	230	27	Immune	immune	VBP
cord-323756-atnrw9ew	230	28	sensing	sensing	NN
cord-323756-atnrw9ew	230	29	of	of	IN
cord-323756-atnrw9ew	230	30	DNA	DNA	NNP
cord-323756-atnrw9ew	230	31	Detection	Detection	NNP
cord-323756-atnrw9ew	230	32	of	of	IN
cord-323756-atnrw9ew	230	33	prokaryotic	prokaryotic	JJ
cord-323756-atnrw9ew	230	34	mRNA	mrna	NN
cord-323756-atnrw9ew	230	35	signifies	signify	VBZ
cord-323756-atnrw9ew	230	36	microbial	microbial	JJ
cord-323756-atnrw9ew	230	37	viability	viability	NN
cord-323756-atnrw9ew	230	38	and	and	CC
cord-323756-atnrw9ew	230	39	promotes	promote	VBZ
cord-323756-atnrw9ew	230	40	immunity	immunity	NN
cord-323756-atnrw9ew	230	41	Principles	principle	NNS
cord-323756-atnrw9ew	230	42	of	of	IN
cord-323756-atnrw9ew	230	43	Virology	Virology	NNP
cord-323756-atnrw9ew	230	44	Cell	Cell	NNP
cord-323756-atnrw9ew	230	45	-	-	HYPH
cord-323756-atnrw9ew	230	46	to	to	IN
cord-323756-atnrw9ew	230	47	-	-	HYPH
cord-323756-atnrw9ew	230	48	cell	cell	NN
cord-323756-atnrw9ew	230	49	transmission	transmission	NN
cord-323756-atnrw9ew	230	50	of	of	IN
cord-323756-atnrw9ew	230	51	viruses	virus	NNS
cord-323756-atnrw9ew	231	1	Plasmacytoid	Plasmacytoid	NNP
cord-323756-atnrw9ew	231	2	dendritic	dendritic	JJ
cord-323756-atnrw9ew	231	3	cells	cell	NNS
cord-323756-atnrw9ew	231	4	sense	sense	VBP
cord-323756-atnrw9ew	231	5	hepatitis	hepatitis	NN
cord-323756-atnrw9ew	231	6	C	C	NNP
cord-323756-atnrw9ew	231	7	virus	virus	NN
cord-323756-atnrw9ew	231	8	-	-	HYPH
cord-323756-atnrw9ew	231	9	infected	infect	VBN
cord-323756-atnrw9ew	231	10	cells	cell	NNS
cord-323756-atnrw9ew	231	11	,	,	,
cord-323756-atnrw9ew	231	12	produce	produce	VBP
cord-323756-atnrw9ew	231	13	interferon	interferon	NN
cord-323756-atnrw9ew	231	14	,	,	,
cord-323756-atnrw9ew	231	15	and	and	CC
cord-323756-atnrw9ew	231	16	inhibit	inhibit	VB
cord-323756-atnrw9ew	231	17	infection	infection	NN
cord-323756-atnrw9ew	232	1	Human	human	JJ
cord-323756-atnrw9ew	232	2	pDCs	pdcs	NN
cord-323756-atnrw9ew	232	3	sense	sense	NN
cord-323756-atnrw9ew	232	4	LCMV	LCMV	NNP
cord-323756-atnrw9ew	232	5	infected	infected	JJ
cord-323756-atnrw9ew	232	6	cells	cell	NNS
cord-323756-atnrw9ew	232	7	in	in	IN
cord-323756-atnrw9ew	232	8	vitro	vitro	FW
cord-323756-atnrw9ew	232	9	Innate	innate	JJ
cord-323756-atnrw9ew	232	10	sensing	sensing	NN
cord-323756-atnrw9ew	232	11	of	of	IN
cord-323756-atnrw9ew	232	12	HIV	HIV	NNP
cord-323756-atnrw9ew	232	13	-	-	HYPH
cord-323756-atnrw9ew	232	14	infected	infect	VBN
cord-323756-atnrw9ew	232	15	cells	cell	NNS
cord-323756-atnrw9ew	232	16	Expression	expression	NN
cord-323756-atnrw9ew	232	17	of	of	IN
cord-323756-atnrw9ew	232	18	animal	animal	NN
cord-323756-atnrw9ew	232	19	virus	virus	NN
cord-323756-atnrw9ew	232	20	genomes	genome	NNS
cord-323756-atnrw9ew	232	21	Bacterial	bacterial	JJ
cord-323756-atnrw9ew	232	22	ligands	ligand	NNS
cord-323756-atnrw9ew	232	23	generated	generate	VBN
cord-323756-atnrw9ew	232	24	in	in	IN
cord-323756-atnrw9ew	232	25	a	a	DT
cord-323756-atnrw9ew	232	26	phagosome	phagosome	NN
cord-323756-atnrw9ew	232	27	are	be	VBP
cord-323756-atnrw9ew	232	28	targets	target	NNS
cord-323756-atnrw9ew	232	29	of	of	IN
cord-323756-atnrw9ew	232	30	the	the	DT
cord-323756-atnrw9ew	232	31	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	232	32	innate	innate	JJ
cord-323756-atnrw9ew	232	33	immune	immune	JJ
cord-323756-atnrw9ew	232	34	system	system	NN
cord-323756-atnrw9ew	232	35	RIG	rig	NN
cord-323756-atnrw9ew	233	1	-I	-i	WP
cord-323756-atnrw9ew	233	2	detects	detect	VBZ
cord-323756-atnrw9ew	233	3	infection	infection	NN
cord-323756-atnrw9ew	233	4	with	with	IN
cord-323756-atnrw9ew	233	5	live	live	JJ
cord-323756-atnrw9ew	233	6	Listeria	Listeria	NNP
cord-323756-atnrw9ew	233	7	by	by	IN
cord-323756-atnrw9ew	233	8	sensing	sense	VBG
cord-323756-atnrw9ew	233	9	secreted	secrete	VBN
cord-323756-atnrw9ew	233	10	bacterial	bacterial	JJ
cord-323756-atnrw9ew	233	11	nucleic	nucleic	JJ
cord-323756-atnrw9ew	233	12	acids	acid	NNS
cord-323756-atnrw9ew	233	13	RIG	rig	NN
cord-323756-atnrw9ew	233	14	-	-	:
cord-323756-atnrw9ew	233	15	I	-PRON-	PRP
cord-323756-atnrw9ew	233	16	detects	detect	VBZ
cord-323756-atnrw9ew	233	17	triphosphorylated	triphosphorylate	VBN
cord-323756-atnrw9ew	233	18	RNA	RNA	NNP
cord-323756-atnrw9ew	233	19	of	of	IN
cord-323756-atnrw9ew	233	20	Listeria	Listeria	NNP
cord-323756-atnrw9ew	233	21	monocytogenes	monocytogene	NNS
cord-323756-atnrw9ew	233	22	during	during	IN
cord-323756-atnrw9ew	233	23	infection	infection	NN
cord-323756-atnrw9ew	233	24	in	in	IN
cord-323756-atnrw9ew	233	25	non	non	JJ
cord-323756-atnrw9ew	233	26	-	-	JJ
cord-323756-atnrw9ew	233	27	immune	immune	JJ
cord-323756-atnrw9ew	233	28	cells	cell	NNS
cord-323756-atnrw9ew	233	29	Identification	identification	NN
cord-323756-atnrw9ew	233	30	of	of	IN
cord-323756-atnrw9ew	233	31	host	host	NN
cord-323756-atnrw9ew	233	32	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	233	33	sensors	sensor	NNS
cord-323756-atnrw9ew	233	34	and	and	CC
cord-323756-atnrw9ew	233	35	bacterial	bacterial	JJ
cord-323756-atnrw9ew	233	36	factors	factor	NNS
cord-323756-atnrw9ew	233	37	regulating	regulate	VBG
cord-323756-atnrw9ew	233	38	the	the	DT
cord-323756-atnrw9ew	233	39	type	type	NN
cord-323756-atnrw9ew	234	1	I	-PRON-	PRP
cord-323756-atnrw9ew	234	2	interferon	interferon	VBD
cord-323756-atnrw9ew	234	3	response	response	NN
cord-323756-atnrw9ew	234	4	to	to	IN
cord-323756-atnrw9ew	234	5	Legionella	Legionella	NNP
cord-323756-atnrw9ew	234	6	pneumophila	pneumophila	NN
cord-323756-atnrw9ew	234	7	RIG	rig	NN
cord-323756-atnrw9ew	234	8	-	-	HYPH
cord-323756-atnrw9ew	234	9	I	i	NN
cord-323756-atnrw9ew	234	10	-	-	HYPH
cord-323756-atnrw9ew	234	11	dependent	dependent	JJ
cord-323756-atnrw9ew	234	12	sensing	sensing	NN
cord-323756-atnrw9ew	234	13	of	of	IN
cord-323756-atnrw9ew	234	14	poly(dA	poly(dA	NNP
cord-323756-atnrw9ew	234	15	:	:	:
cord-323756-atnrw9ew	234	16	dT	dT	NNP
cord-323756-atnrw9ew	234	17	)	)	-RRB-
cord-323756-atnrw9ew	234	18	through	through	IN
cord-323756-atnrw9ew	234	19	the	the	DT
cord-323756-atnrw9ew	234	20	induction	induction	NN
cord-323756-atnrw9ew	234	21	of	of	IN
cord-323756-atnrw9ew	234	22	an	an	DT
cord-323756-atnrw9ew	234	23	RNA	RNA	NNP
cord-323756-atnrw9ew	234	24	polymerase	polymerase	NN
cord-323756-atnrw9ew	234	25	III	III	NNP
cord-323756-atnrw9ew	234	26	-	-	HYPH
cord-323756-atnrw9ew	234	27	transcribed	transcribe	VBN
cord-323756-atnrw9ew	234	28	RNA	RNA	NNP
cord-323756-atnrw9ew	234	29	intermediate	intermediate	NNP
cord-323756-atnrw9ew	234	30	RNA	RNA	NNP
cord-323756-atnrw9ew	234	31	polymerase	polymerase	NN
cord-323756-atnrw9ew	234	32	III	III	NNP
cord-323756-atnrw9ew	234	33	detects	detect	VBZ
cord-323756-atnrw9ew	234	34	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	234	35	DNA	dna	NN
cord-323756-atnrw9ew	234	36	and	and	CC
cord-323756-atnrw9ew	234	37	induces	induce	VBZ
cord-323756-atnrw9ew	234	38	type	type	NN
cord-323756-atnrw9ew	234	39	I	-PRON-	PRP
cord-323756-atnrw9ew	234	40	interferons	interferon	NNS
cord-323756-atnrw9ew	234	41	through	through	IN
cord-323756-atnrw9ew	234	42	the	the	DT
cord-323756-atnrw9ew	234	43	RIG	rig	NN
cord-323756-atnrw9ew	234	44	-	-	:
cord-323756-atnrw9ew	234	45	I	-PRON-	PRP
cord-323756-atnrw9ew	234	46	pathway	pathway	VBP
cord-323756-atnrw9ew	234	47	IPS-1	IPS-1	NNP
cord-323756-atnrw9ew	234	48	,	,	,
cord-323756-atnrw9ew	234	49	an	an	DT
cord-323756-atnrw9ew	234	50	adaptor	adaptor	NN
cord-323756-atnrw9ew	234	51	triggering	trigger	VBG
cord-323756-atnrw9ew	234	52	RIG	rig	NN
cord-323756-atnrw9ew	234	53	-	-	HYPH
cord-323756-atnrw9ew	234	54	I	i	NN
cord-323756-atnrw9ew	234	55	-	-	HYPH
cord-323756-atnrw9ew	234	56	and	and	CC
cord-323756-atnrw9ew	234	57	Mda5-mediated	Mda5-mediated	NNP
cord-323756-atnrw9ew	235	1	type	type	NN
cord-323756-atnrw9ew	236	1	I	-PRON-	PRP
cord-323756-atnrw9ew	237	1	interferon	interferon	NNP
cord-323756-atnrw9ew	237	2	induction	induction	NN
cord-323756-atnrw9ew	237	3	Cardif	Cardif	NNP
cord-323756-atnrw9ew	237	4	is	be	VBZ
cord-323756-atnrw9ew	237	5	an	an	DT
cord-323756-atnrw9ew	237	6	adaptor	adaptor	NN
cord-323756-atnrw9ew	237	7	protein	protein	NN
cord-323756-atnrw9ew	237	8	in	in	IN
cord-323756-atnrw9ew	237	9	the	the	DT
cord-323756-atnrw9ew	237	10	RIG	rig	NN
cord-323756-atnrw9ew	237	11	-	-	:
cord-323756-atnrw9ew	237	12	I	I	NNP
cord-323756-atnrw9ew	237	13	antiviral	antiviral	JJ
cord-323756-atnrw9ew	237	14	pathway	pathway	NN
cord-323756-atnrw9ew	237	15	and	and	CC
cord-323756-atnrw9ew	237	16	is	be	VBZ
cord-323756-atnrw9ew	237	17	targeted	target	VBN
cord-323756-atnrw9ew	237	18	by	by	IN
cord-323756-atnrw9ew	237	19	hepatitis	hepatitis	NN
cord-323756-atnrw9ew	237	20	C	C	NNP
cord-323756-atnrw9ew	237	21	virus	virus	NN
cord-323756-atnrw9ew	237	22	Identification	identification	NN
cord-323756-atnrw9ew	237	23	and	and	CC
cord-323756-atnrw9ew	237	24	characterization	characterization	NN
cord-323756-atnrw9ew	237	25	of	of	IN
cord-323756-atnrw9ew	237	26	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	237	27	,	,	,
cord-323756-atnrw9ew	237	28	a	a	DT
cord-323756-atnrw9ew	237	29	mitochondrial	mitochondrial	JJ
cord-323756-atnrw9ew	237	30	antiviral	antiviral	JJ
cord-323756-atnrw9ew	237	31	signaling	signal	VBG
cord-323756-atnrw9ew	237	32	protein	protein	NN
cord-323756-atnrw9ew	237	33	that	that	WDT
cord-323756-atnrw9ew	237	34	activates	activate	VBZ
cord-323756-atnrw9ew	237	35	NF	NF	NNP
cord-323756-atnrw9ew	237	36	-	-	HYPH
cord-323756-atnrw9ew	237	37	kappaB	kappaB	NNP
cord-323756-atnrw9ew	237	38	and	and	CC
cord-323756-atnrw9ew	237	39	IRF	IRF	NNP
cord-323756-atnrw9ew	237	40	3	3	CD
cord-323756-atnrw9ew	237	41	VISA	VISA	NNP
cord-323756-atnrw9ew	237	42	is	be	VBZ
cord-323756-atnrw9ew	237	43	an	an	DT
cord-323756-atnrw9ew	237	44	adapter	adapter	NN
cord-323756-atnrw9ew	237	45	protein	protein	NN
cord-323756-atnrw9ew	237	46	required	require	VBN
cord-323756-atnrw9ew	237	47	for	for	IN
cord-323756-atnrw9ew	237	48	virus	virus	NN
cord-323756-atnrw9ew	237	49	-	-	HYPH
cord-323756-atnrw9ew	237	50	triggered	trigger	VBN
cord-323756-atnrw9ew	237	51	IFN	IFN	NNP
cord-323756-atnrw9ew	237	52	-	-	HYPH
cord-323756-atnrw9ew	237	53	beta	beta	NN
cord-323756-atnrw9ew	237	54	signaling	signal	VBG
cord-323756-atnrw9ew	237	55	Expression	expression	NN
cord-323756-atnrw9ew	237	56	analysis	analysis	NN
cord-323756-atnrw9ew	237	57	and	and	CC
cord-323756-atnrw9ew	237	58	genomic	genomic	JJ
cord-323756-atnrw9ew	237	59	characterization	characterization	NN
cord-323756-atnrw9ew	237	60	of	of	IN
cord-323756-atnrw9ew	237	61	human	human	JJ
cord-323756-atnrw9ew	237	62	melanoma	melanoma	NN
cord-323756-atnrw9ew	237	63	differentiation	differentiation	NN
cord-323756-atnrw9ew	237	64	associated	associate	VBN
cord-323756-atnrw9ew	237	65	gene-5	gene-5	NNP
cord-323756-atnrw9ew	237	66	,	,	,
cord-323756-atnrw9ew	237	67	mda-5	mda-5	NNP
cord-323756-atnrw9ew	237	68	:	:	:
cord-323756-atnrw9ew	237	69	a	a	DT
cord-323756-atnrw9ew	237	70	novel	novel	JJ
cord-323756-atnrw9ew	237	71	type	type	NN
cord-323756-atnrw9ew	238	1	I	-PRON-	PRP
cord-323756-atnrw9ew	238	2	interferon	interferon	NN
cord-323756-atnrw9ew	238	3	-	-	HYPH
cord-323756-atnrw9ew	238	4	responsive	responsive	JJ
cord-323756-atnrw9ew	238	5	apoptosis	apoptosis	NN
cord-323756-atnrw9ew	238	6	-	-	HYPH
cord-323756-atnrw9ew	238	7	inducing	induce	VBG
cord-323756-atnrw9ew	238	8	gene	gene	NN
cord-323756-atnrw9ew	239	1	The	the	DT
cord-323756-atnrw9ew	239	2	RNA	RNA	NNP
cord-323756-atnrw9ew	239	3	helicase	helicase	NN
cord-323756-atnrw9ew	239	4	RIG	rig	NN
cord-323756-atnrw9ew	239	5	-	-	:
cord-323756-atnrw9ew	239	6	I	-PRON-	PRP
cord-323756-atnrw9ew	239	7	has	have	VBZ
cord-323756-atnrw9ew	239	8	an	an	DT
cord-323756-atnrw9ew	239	9	essential	essential	JJ
cord-323756-atnrw9ew	239	10	function	function	NN
cord-323756-atnrw9ew	239	11	in	in	IN
cord-323756-atnrw9ew	239	12	double	double	RB
cord-323756-atnrw9ew	239	13	-	-	HYPH
cord-323756-atnrw9ew	239	14	stranded	strand	VBN
cord-323756-atnrw9ew	239	15	RNA	rna	NN
cord-323756-atnrw9ew	239	16	-	-	HYPH
cord-323756-atnrw9ew	239	17	induced	induce	VBN
cord-323756-atnrw9ew	239	18	innate	innate	JJ
cord-323756-atnrw9ew	239	19	antiviral	antiviral	JJ
cord-323756-atnrw9ew	239	20	responses	response	NNS
cord-323756-atnrw9ew	240	1	5'-Triphosphate	5'-Triphosphate	NNP
cord-323756-atnrw9ew	240	2	RNA	RNA	NNP
cord-323756-atnrw9ew	240	3	is	be	VBZ
cord-323756-atnrw9ew	240	4	the	the	DT
cord-323756-atnrw9ew	240	5	ligand	ligand	NN
cord-323756-atnrw9ew	240	6	for	for	IN
cord-323756-atnrw9ew	240	7	RIG	rig	NN
cord-323756-atnrw9ew	240	8	-	-	:
cord-323756-atnrw9ew	240	9	I	I	NNP
cord-323756-atnrw9ew	240	10	RIG	rig	NN
cord-323756-atnrw9ew	240	11	-	-	:
cord-323756-atnrw9ew	240	12	I	i	NN
cord-323756-atnrw9ew	240	13	-	-	HYPH
cord-323756-atnrw9ew	240	14	mediated	mediate	VBN
cord-323756-atnrw9ew	240	15	antiviral	antiviral	JJ
cord-323756-atnrw9ew	240	16	responses	response	NNS
cord-323756-atnrw9ew	240	17	to	to	IN
cord-323756-atnrw9ew	240	18	single	single	RB
cord-323756-atnrw9ew	240	19	-	-	HYPH
cord-323756-atnrw9ew	240	20	stranded	strand	VBN
cord-323756-atnrw9ew	240	21	RNA	RNA	NNP
cord-323756-atnrw9ew	240	22	bearing	bear	VBG
cord-323756-atnrw9ew	240	23	5'-phosphates	5'-phosphates	CD
cord-323756-atnrw9ew	241	1	Recognition	recognition	NN
cord-323756-atnrw9ew	241	2	of	of	IN
cord-323756-atnrw9ew	241	3	5	5	CD
cord-323756-atnrw9ew	241	4	'	'	''
cord-323756-atnrw9ew	241	5	triphosphate	triphosphate	NN
cord-323756-atnrw9ew	241	6	by	by	IN
cord-323756-atnrw9ew	241	7	RIG	rig	NN
cord-323756-atnrw9ew	242	1	-I	-i	DT
cord-323756-atnrw9ew	242	2	helicase	helicase	NNP
cord-323756-atnrw9ew	242	3	requires	require	VBZ
cord-323756-atnrw9ew	242	4	short	short	JJ
cord-323756-atnrw9ew	242	5	blunt	blunt	JJ
cord-323756-atnrw9ew	242	6	doublestranded	doublestranded	NNP
cord-323756-atnrw9ew	242	7	RNA	RNA	NNP
cord-323756-atnrw9ew	242	8	as	as	IN
cord-323756-atnrw9ew	242	9	contained	contain	VBN
cord-323756-atnrw9ew	242	10	in	in	IN
cord-323756-atnrw9ew	242	11	panhandle	panhandle	NN
cord-323756-atnrw9ew	242	12	of	of	IN
cord-323756-atnrw9ew	242	13	negative	negative	JJ
cord-323756-atnrw9ew	242	14	-	-	HYPH
cord-323756-atnrw9ew	242	15	strand	strand	NN
cord-323756-atnrw9ew	242	16	virus	virus	NN
cord-323756-atnrw9ew	243	1	5'-Triphosphate	5'-Triphosphate	NNP
cord-323756-atnrw9ew	243	2	RNA	RNA	NNP
cord-323756-atnrw9ew	243	3	requires	require	VBZ
cord-323756-atnrw9ew	243	4	base	base	NN
cord-323756-atnrw9ew	243	5	-	-	HYPH
cord-323756-atnrw9ew	243	6	paired	pair	VBN
cord-323756-atnrw9ew	243	7	structures	structure	NNS
cord-323756-atnrw9ew	243	8	to	to	TO
cord-323756-atnrw9ew	243	9	activate	activate	VB
cord-323756-atnrw9ew	243	10	antiviral	antiviral	JJ
cord-323756-atnrw9ew	243	11	signaling	signaling	NN
cord-323756-atnrw9ew	243	12	via	via	IN
cord-323756-atnrw9ew	243	13	RIG	rig	NN
cord-323756-atnrw9ew	243	14	-	-	:
cord-323756-atnrw9ew	243	15	I	I	NNP
cord-323756-atnrw9ew	243	16	Structural	structural	JJ
cord-323756-atnrw9ew	243	17	basis	basis	NN
cord-323756-atnrw9ew	243	18	of	of	IN
cord-323756-atnrw9ew	243	19	RNA	RNA	NNP
cord-323756-atnrw9ew	243	20	recognition	recognition	NN
cord-323756-atnrw9ew	243	21	and	and	CC
cord-323756-atnrw9ew	243	22	activation	activation	NN
cord-323756-atnrw9ew	243	23	by	by	IN
cord-323756-atnrw9ew	243	24	innate	innate	JJ
cord-323756-atnrw9ew	243	25	immune	immune	JJ
cord-323756-atnrw9ew	243	26	receptor	receptor	NN
cord-323756-atnrw9ew	243	27	RIG	rig	NN
cord-323756-atnrw9ew	243	28	-	-	:
cord-323756-atnrw9ew	243	29	I	I	NNP
cord-323756-atnrw9ew	243	30	Structural	structural	JJ
cord-323756-atnrw9ew	243	31	basis	basis	NN
cord-323756-atnrw9ew	243	32	for	for	IN
cord-323756-atnrw9ew	243	33	the	the	DT
cord-323756-atnrw9ew	243	34	activation	activation	NN
cord-323756-atnrw9ew	243	35	of	of	IN
cord-323756-atnrw9ew	243	36	innate	innate	JJ
cord-323756-atnrw9ew	243	37	immune	immune	JJ
cord-323756-atnrw9ew	243	38	pattern	pattern	NN
cord-323756-atnrw9ew	243	39	-	-	HYPH
cord-323756-atnrw9ew	243	40	recognition	recognition	NN
cord-323756-atnrw9ew	243	41	receptor	receptor	NN
cord-323756-atnrw9ew	243	42	RIG	rig	NN
cord-323756-atnrw9ew	244	1	-I	-I	NFP
cord-323756-atnrw9ew	244	2	by	by	IN
cord-323756-atnrw9ew	244	3	viral	viral	JJ
cord-323756-atnrw9ew	244	4	RNA	RNA	NNP
cord-323756-atnrw9ew	244	5	Structural	structural	JJ
cord-323756-atnrw9ew	244	6	insights	insight	NNS
cord-323756-atnrw9ew	244	7	into	into	IN
cord-323756-atnrw9ew	244	8	RNA	RNA	NNP
cord-323756-atnrw9ew	244	9	recognition	recognition	NN
cord-323756-atnrw9ew	244	10	by	by	IN
cord-323756-atnrw9ew	244	11	RIG	rig	NN
cord-323756-atnrw9ew	244	12	-	-	:
cord-323756-atnrw9ew	244	13	I	I	NNP
cord-323756-atnrw9ew	244	14	Molecular	Molecular	NNP
cord-323756-atnrw9ew	244	15	mechanism	mechanism	NN
cord-323756-atnrw9ew	244	16	of	of	IN
cord-323756-atnrw9ew	244	17	signal	signal	JJ
cord-323756-atnrw9ew	244	18	perception	perception	NN
cord-323756-atnrw9ew	244	19	and	and	CC
cord-323756-atnrw9ew	244	20	integration	integration	NN
cord-323756-atnrw9ew	244	21	by	by	IN
cord-323756-atnrw9ew	244	22	the	the	DT
cord-323756-atnrw9ew	244	23	innate	innate	JJ
cord-323756-atnrw9ew	244	24	immune	immune	JJ
cord-323756-atnrw9ew	244	25	sensor	sensor	NN
cord-323756-atnrw9ew	244	26	retinoic	retinoic	JJ
cord-323756-atnrw9ew	244	27	acid	acid	NN
cord-323756-atnrw9ew	244	28	-	-	HYPH
cord-323756-atnrw9ew	244	29	inducible	inducible	JJ
cord-323756-atnrw9ew	244	30	gene	gene	NN
cord-323756-atnrw9ew	244	31	-	-	:
cord-323756-atnrw9ew	244	32	I	i	NN
cord-323756-atnrw9ew	244	33	(	(	-LRB-
cord-323756-atnrw9ew	244	34	RIG	rig	NN
cord-323756-atnrw9ew	244	35	-	-	:
cord-323756-atnrw9ew	244	36	I	i	NN
cord-323756-atnrw9ew	244	37	)	)	-RRB-
cord-323756-atnrw9ew	245	1	A	a	DT
cord-323756-atnrw9ew	245	2	structural	structural	JJ
cord-323756-atnrw9ew	245	3	basis	basis	NN
cord-323756-atnrw9ew	245	4	for	for	IN
cord-323756-atnrw9ew	245	5	discriminating	discriminate	VBG
cord-323756-atnrw9ew	245	6	between	between	IN
cord-323756-atnrw9ew	245	7	self	self	NN
cord-323756-atnrw9ew	245	8	and	and	CC
cord-323756-atnrw9ew	245	9	nonself	nonself	NN
cord-323756-atnrw9ew	245	10	double	double	RB
cord-323756-atnrw9ew	245	11	-	-	HYPH
cord-323756-atnrw9ew	245	12	stranded	strand	VBN
cord-323756-atnrw9ew	245	13	RNAs	rna	NNS
cord-323756-atnrw9ew	245	14	in	in	IN
cord-323756-atnrw9ew	245	15	mammalian	mammalian	JJ
cord-323756-atnrw9ew	245	16	cells	cell	NNS
cord-323756-atnrw9ew	245	17	Length	length	NN
cord-323756-atnrw9ew	245	18	-	-	HYPH
cord-323756-atnrw9ew	245	19	dependent	dependent	JJ
cord-323756-atnrw9ew	245	20	recognition	recognition	NN
cord-323756-atnrw9ew	245	21	of	of	IN
cord-323756-atnrw9ew	245	22	double	double	RB
cord-323756-atnrw9ew	245	23	-	-	HYPH
cord-323756-atnrw9ew	245	24	stranded	strand	VBN
cord-323756-atnrw9ew	245	25	ribonucleic	ribonucleic	JJ
cord-323756-atnrw9ew	245	26	acids	acid	NNS
cord-323756-atnrw9ew	245	27	by	by	IN
cord-323756-atnrw9ew	245	28	retinoic	retinoic	JJ
cord-323756-atnrw9ew	245	29	acid	acid	NN
cord-323756-atnrw9ew	245	30	-	-	HYPH
cord-323756-atnrw9ew	245	31	inducible	inducible	JJ
cord-323756-atnrw9ew	245	32	gene	gene	NN
cord-323756-atnrw9ew	245	33	-	-	:
cord-323756-atnrw9ew	245	34	I	i	NN
cord-323756-atnrw9ew	245	35	and	and	CC
cord-323756-atnrw9ew	245	36	melanoma	melanoma	NN
cord-323756-atnrw9ew	245	37	differentiation	differentiation	NN
cord-323756-atnrw9ew	245	38	-	-	HYPH
cord-323756-atnrw9ew	245	39	associated	associate	VBN
cord-323756-atnrw9ew	245	40	gene	gene	NN
cord-323756-atnrw9ew	245	41	Nonself	Nonself	NNP
cord-323756-atnrw9ew	245	42	RNA	RNA	NNP
cord-323756-atnrw9ew	245	43	-	-	HYPH
cord-323756-atnrw9ew	245	44	sensing	sense	VBG
cord-323756-atnrw9ew	245	45	mechanism	mechanism	NN
cord-323756-atnrw9ew	245	46	of	of	IN
cord-323756-atnrw9ew	245	47	RIG-	RIG-	NNP
cord-323756-atnrw9ew	246	1	I	-PRON-	PRP
cord-323756-atnrw9ew	246	2	helicase	helicase	VBD
cord-323756-atnrw9ew	246	3	and	and	CC
cord-323756-atnrw9ew	246	4	activation	activation	NN
cord-323756-atnrw9ew	246	5	of	of	IN
cord-323756-atnrw9ew	246	6	antiviral	antiviral	JJ
cord-323756-atnrw9ew	246	7	immune	immune	JJ
cord-323756-atnrw9ew	246	8	responses	response	NNS
cord-323756-atnrw9ew	247	1	The	the	DT
cord-323756-atnrw9ew	247	2	thermodynamic	thermodynamic	JJ
cord-323756-atnrw9ew	247	3	basis	basis	NN
cord-323756-atnrw9ew	247	4	for	for	IN
cord-323756-atnrw9ew	247	5	viral	viral	JJ
cord-323756-atnrw9ew	247	6	RNA	RNA	NNP
cord-323756-atnrw9ew	247	7	detection	detection	NN
cord-323756-atnrw9ew	247	8	by	by	IN
cord-323756-atnrw9ew	247	9	the	the	DT
cord-323756-atnrw9ew	247	10	RIG	rig	NN
cord-323756-atnrw9ew	247	11	-	-	:
cord-323756-atnrw9ew	247	12	I	-PRON-	PRP
cord-323756-atnrw9ew	247	13	innate	innate	VBP
cord-323756-atnrw9ew	247	14	immune	immune	JJ
cord-323756-atnrw9ew	247	15	sensor	sensor	NN
cord-323756-atnrw9ew	247	16	RIG	rig	NN
cord-323756-atnrw9ew	248	1	-I	-I	NNP
cord-323756-atnrw9ew	248	2	detects	detect	VBZ
cord-323756-atnrw9ew	248	3	viral	viral	JJ
cord-323756-atnrw9ew	248	4	genomic	genomic	JJ
cord-323756-atnrw9ew	248	5	RNA	RNA	NNP
cord-323756-atnrw9ew	248	6	during	during	IN
cord-323756-atnrw9ew	248	7	negative	negative	JJ
cord-323756-atnrw9ew	248	8	-	-	HYPH
cord-323756-atnrw9ew	248	9	strand	strand	NN
cord-323756-atnrw9ew	248	10	RNA	RNA	NNP
cord-323756-atnrw9ew	248	11	virus	virus	NN
cord-323756-atnrw9ew	248	12	infection	infection	NN
cord-323756-atnrw9ew	248	13	Incoming	Incoming	NNP
cord-323756-atnrw9ew	248	14	RNA	RNA	NNP
cord-323756-atnrw9ew	248	15	virus	virus	NN
cord-323756-atnrw9ew	248	16	nucleocapsids	nucleocapsid	NNS
cord-323756-atnrw9ew	248	17	containing	contain	VBG
cord-323756-atnrw9ew	249	1	a	a	DT
cord-323756-atnrw9ew	249	2	5'-triphosphorylated	5'-triphosphorylate	VBN
cord-323756-atnrw9ew	249	3	genome	genome	NN
cord-323756-atnrw9ew	249	4	activate	activate	VBP
cord-323756-atnrw9ew	249	5	RIG	rig	NN
cord-323756-atnrw9ew	249	6	-	-	:
cord-323756-atnrw9ew	249	7	I	i	NN
cord-323756-atnrw9ew	249	8	and	and	CC
cord-323756-atnrw9ew	249	9	antiviral	antiviral	JJ
cord-323756-atnrw9ew	249	10	signaling	signal	VBG
cord-323756-atnrw9ew	249	11	Differential	differential	JJ
cord-323756-atnrw9ew	249	12	roles	role	NNS
cord-323756-atnrw9ew	249	13	of	of	IN
cord-323756-atnrw9ew	249	14	MDA5	MDA5	NNP
cord-323756-atnrw9ew	249	15	and	and	CC
cord-323756-atnrw9ew	249	16	RIG	rig	NN
cord-323756-atnrw9ew	250	1	-I	-i	DT
cord-323756-atnrw9ew	250	2	helicases	helicase	NNS
cord-323756-atnrw9ew	250	3	in	in	IN
cord-323756-atnrw9ew	250	4	the	the	DT
cord-323756-atnrw9ew	250	5	recognition	recognition	NN
cord-323756-atnrw9ew	250	6	of	of	IN
cord-323756-atnrw9ew	250	7	RNA	RNA	NNP
cord-323756-atnrw9ew	250	8	viruses	virus	NNS
cord-323756-atnrw9ew	251	1	Innate	innate	JJ
cord-323756-atnrw9ew	251	2	immunity	immunity	NN
cord-323756-atnrw9ew	251	3	induced	induce	VBN
cord-323756-atnrw9ew	251	4	by	by	IN
cord-323756-atnrw9ew	251	5	composition	composition	NN
cord-323756-atnrw9ew	251	6	-	-	HYPH
cord-323756-atnrw9ew	251	7	dependent	dependent	JJ
cord-323756-atnrw9ew	251	8	RIG	rig	NN
cord-323756-atnrw9ew	251	9	-	-	:
cord-323756-atnrw9ew	251	10	I	-PRON-	PRP
cord-323756-atnrw9ew	251	11	recognition	recognition	NN
cord-323756-atnrw9ew	251	12	of	of	IN
cord-323756-atnrw9ew	251	13	hepatitis	hepatitis	NNP
cord-323756-atnrw9ew	251	14	C	C	NNP
cord-323756-atnrw9ew	251	15	virus	virus	NN
cord-323756-atnrw9ew	251	16	RNA	RNA	NNP
cord-323756-atnrw9ew	251	17	Preference	Preference	NNP
cord-323756-atnrw9ew	251	18	of	of	IN
cord-323756-atnrw9ew	251	19	RIG	rig	NN
cord-323756-atnrw9ew	252	1	-I	-I	NFP
cord-323756-atnrw9ew	252	2	for	for	IN
cord-323756-atnrw9ew	252	3	short	short	JJ
cord-323756-atnrw9ew	252	4	viral	viral	JJ
cord-323756-atnrw9ew	252	5	RNA	RNA	NNP
cord-323756-atnrw9ew	252	6	molecules	molecule	NNS
cord-323756-atnrw9ew	252	7	in	in	IN
cord-323756-atnrw9ew	252	8	infected	infected	JJ
cord-323756-atnrw9ew	252	9	cells	cell	NNS
cord-323756-atnrw9ew	252	10	revealed	reveal	VBN
cord-323756-atnrw9ew	252	11	by	by	IN
cord-323756-atnrw9ew	252	12	next	next	JJ
cord-323756-atnrw9ew	252	13	-	-	HYPH
cord-323756-atnrw9ew	252	14	generation	generation	NN
cord-323756-atnrw9ew	252	15	sequencing	sequence	VBG
cord-323756-atnrw9ew	252	16	Epstein	Epstein	NNP
cord-323756-atnrw9ew	252	17	-	-	HYPH
cord-323756-atnrw9ew	252	18	Barr	Barr	NNP
cord-323756-atnrw9ew	252	19	virus	virus	NN
cord-323756-atnrw9ew	252	20	-	-	HYPH
cord-323756-atnrw9ew	252	21	encoded	encode	VBN
cord-323756-atnrw9ew	252	22	small	small	JJ
cord-323756-atnrw9ew	252	23	RNA	RNA	NNP
cord-323756-atnrw9ew	252	24	induces	induce	VBZ
cord-323756-atnrw9ew	252	25	IL-10	IL-10	NNP
cord-323756-atnrw9ew	252	26	through	through	IN
cord-323756-atnrw9ew	252	27	RIG	rig	NN
cord-323756-atnrw9ew	252	28	-	-	HYPH
cord-323756-atnrw9ew	252	29	I	i	NN
cord-323756-atnrw9ew	252	30	-	-	HYPH
cord-323756-atnrw9ew	252	31	mediated	mediate	VBN
cord-323756-atnrw9ew	252	32	IRF-3	IRF-3	NNP
cord-323756-atnrw9ew	252	33	signaling	signal	VBG
cord-323756-atnrw9ew	252	34	Adenovirus	Adenovirus	NNP
cord-323756-atnrw9ew	252	35	virus	virus	NN
cord-323756-atnrw9ew	252	36	-	-	HYPH
cord-323756-atnrw9ew	252	37	associated	associate	VBN
cord-323756-atnrw9ew	252	38	RNAs	rna	NNS
cord-323756-atnrw9ew	253	1	induce	induce	VB
cord-323756-atnrw9ew	253	2	type	type	NN
cord-323756-atnrw9ew	254	1	I	-PRON-	PRP
cord-323756-atnrw9ew	254	2	interferon	interferon	VBD
cord-323756-atnrw9ew	254	3	expression	expression	NN
cord-323756-atnrw9ew	254	4	through	through	IN
cord-323756-atnrw9ew	254	5	a	a	DT
cord-323756-atnrw9ew	254	6	RIG	rig	NN
cord-323756-atnrw9ew	254	7	-	-	HYPH
cord-323756-atnrw9ew	254	8	I	i	NN
cord-323756-atnrw9ew	254	9	-	-	HYPH
cord-323756-atnrw9ew	254	10	mediated	mediate	VBN
cord-323756-atnrw9ew	254	11	pathway	pathway	NN
cord-323756-atnrw9ew	255	1	The	the	DT
cord-323756-atnrw9ew	255	2	5	5	CD
cord-323756-atnrw9ew	255	3	'	'	POS
cord-323756-atnrw9ew	255	4	ends	end	NNS
cord-323756-atnrw9ew	255	5	of	of	IN
cord-323756-atnrw9ew	255	6	RNA	RNA	NNP
cord-323756-atnrw9ew	255	7	oligonucleotides	oligonucleotide	NNS
cord-323756-atnrw9ew	255	8	in	in	IN
cord-323756-atnrw9ew	255	9	Escherichia	Escherichia	NNP
cord-323756-atnrw9ew	255	10	coli	coli	NNS
cord-323756-atnrw9ew	255	11	and	and	CC
cord-323756-atnrw9ew	255	12	mRNA	mrna	NN
cord-323756-atnrw9ew	255	13	degradation	degradation	NN
cord-323756-atnrw9ew	255	14	Extracellular	Extracellular	NNP
cord-323756-atnrw9ew	255	15	and	and	CC
cord-323756-atnrw9ew	255	16	intracellular	intracellular	JJ
cord-323756-atnrw9ew	255	17	pattern	pattern	NN
cord-323756-atnrw9ew	255	18	recognition	recognition	NN
cord-323756-atnrw9ew	255	19	receptors	receptor	NNS
cord-323756-atnrw9ew	255	20	cooperate	cooperate	VBP
cord-323756-atnrw9ew	255	21	in	in	IN
cord-323756-atnrw9ew	255	22	the	the	DT
cord-323756-atnrw9ew	255	23	recognition	recognition	NN
cord-323756-atnrw9ew	255	24	of	of	IN
cord-323756-atnrw9ew	255	25	Helicobacter	Helicobacter	NNP
cord-323756-atnrw9ew	255	26	pylori	pylori	NN
cord-323756-atnrw9ew	256	1	IFNgamma	IFNgamma	NNP
cord-323756-atnrw9ew	256	2	inhibits	inhibit	VBZ
cord-323756-atnrw9ew	256	3	the	the	DT
cord-323756-atnrw9ew	256	4	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	256	5	replication	replication	NN
cord-323756-atnrw9ew	256	6	of	of	IN
cord-323756-atnrw9ew	256	7	Shigella	Shigella	NNP
cord-323756-atnrw9ew	256	8	flexneri	flexneri	NN
cord-323756-atnrw9ew	256	9	via	via	IN
cord-323756-atnrw9ew	256	10	the	the	DT
cord-323756-atnrw9ew	256	11	cytoplasmic	cytoplasmic	JJ
cord-323756-atnrw9ew	256	12	RNA	RNA	NNP
cord-323756-atnrw9ew	256	13	sensor	sensor	NN
cord-323756-atnrw9ew	256	14	RIG-	RIG-	NNP
cord-323756-atnrw9ew	257	1	I	-PRON-	PRP
cord-323756-atnrw9ew	257	2	Essential	essential	JJ
cord-323756-atnrw9ew	257	3	role	role	NN
cord-323756-atnrw9ew	257	4	of	of	IN
cord-323756-atnrw9ew	257	5	mda-5	mda-5	NNP
cord-323756-atnrw9ew	258	1	in	in	IN
cord-323756-atnrw9ew	258	2	type	type	NN
cord-323756-atnrw9ew	259	1	I	-PRON-	PRP
cord-323756-atnrw9ew	259	2	IFN	IFN	NNP
cord-323756-atnrw9ew	259	3	responses	response	NNS
cord-323756-atnrw9ew	259	4	to	to	IN
cord-323756-atnrw9ew	259	5	polyriboinosinic	polyriboinosinic	NNP
cord-323756-atnrw9ew	259	6	:	:	:
cord-323756-atnrw9ew	259	7	polyribocytidylic	polyribocytidylic	JJ
cord-323756-atnrw9ew	259	8	acid	acid	NN
cord-323756-atnrw9ew	259	9	and	and	CC
cord-323756-atnrw9ew	259	10	encephalomyocarditis	encephalomyocarditis	NNP
cord-323756-atnrw9ew	259	11	picornavirus	picornavirus	NNP
cord-323756-atnrw9ew	259	12	Structural	structural	JJ
cord-323756-atnrw9ew	259	13	basis	basis	NN
cord-323756-atnrw9ew	259	14	for	for	IN
cord-323756-atnrw9ew	259	15	dsRNA	dsrna	NN
cord-323756-atnrw9ew	259	16	recognition	recognition	NN
cord-323756-atnrw9ew	259	17	,	,	,
cord-323756-atnrw9ew	259	18	filament	filament	NN
cord-323756-atnrw9ew	259	19	formation	formation	NN
cord-323756-atnrw9ew	259	20	,	,	,
cord-323756-atnrw9ew	259	21	and	and	CC
cord-323756-atnrw9ew	259	22	antiviral	antiviral	JJ
cord-323756-atnrw9ew	259	23	signal	signal	NN
cord-323756-atnrw9ew	259	24	activation	activation	NN
cord-323756-atnrw9ew	259	25	by	by	IN
cord-323756-atnrw9ew	259	26	MDA5	MDA5	NNP
cord-323756-atnrw9ew	259	27	Double	Double	NNP
cord-323756-atnrw9ew	259	28	-	-	HYPH
cord-323756-atnrw9ew	259	29	stranded	strand	VBN
cord-323756-atnrw9ew	259	30	RNA	RNA	NNP
cord-323756-atnrw9ew	259	31	is	be	VBZ
cord-323756-atnrw9ew	259	32	produced	produce	VBN
cord-323756-atnrw9ew	259	33	by	by	IN
cord-323756-atnrw9ew	259	34	positive	positive	JJ
cord-323756-atnrw9ew	259	35	-	-	HYPH
cord-323756-atnrw9ew	259	36	strand	strand	NN
cord-323756-atnrw9ew	259	37	RNA	RNA	NNP
cord-323756-atnrw9ew	259	38	viruses	virus	NNS
cord-323756-atnrw9ew	259	39	and	and	CC
cord-323756-atnrw9ew	259	40	DNA	dna	NN
cord-323756-atnrw9ew	259	41	viruses	virus	NNS
cord-323756-atnrw9ew	259	42	but	but	CC
cord-323756-atnrw9ew	259	43	not	not	RB
cord-323756-atnrw9ew	259	44	in	in	IN
cord-323756-atnrw9ew	259	45	detectable	detectable	JJ
cord-323756-atnrw9ew	259	46	amounts	amount	NNS
cord-323756-atnrw9ew	259	47	by	by	IN
cord-323756-atnrw9ew	259	48	negative	negative	JJ
cord-323756-atnrw9ew	259	49	-	-	HYPH
cord-323756-atnrw9ew	259	50	strand	strand	NN
cord-323756-atnrw9ew	259	51	RNA	RNA	NNP
cord-323756-atnrw9ew	259	52	viruses	virus	NNS
cord-323756-atnrw9ew	259	53	Activation	Activation	NNP
cord-323756-atnrw9ew	259	54	of	of	IN
cord-323756-atnrw9ew	259	55	MDA5	MDA5	NNP
cord-323756-atnrw9ew	259	56	requires	require	VBZ
cord-323756-atnrw9ew	259	57	higher	high	JJR
cord-323756-atnrw9ew	259	58	-	-	HYPH
cord-323756-atnrw9ew	259	59	order	order	NN
cord-323756-atnrw9ew	259	60	RNA	RNA	NNP
cord-323756-atnrw9ew	259	61	structures	structure	NNS
cord-323756-atnrw9ew	259	62	generated	generate	VBN
cord-323756-atnrw9ew	259	63	during	during	IN
cord-323756-atnrw9ew	259	64	virus	virus	NN
cord-323756-atnrw9ew	259	65	infection	infection	NN
cord-323756-atnrw9ew	259	66	MDA5	MDA5	NNP
cord-323756-atnrw9ew	259	67	detects	detect	VBZ
cord-323756-atnrw9ew	259	68	the	the	DT
cord-323756-atnrw9ew	259	69	double	double	RB
cord-323756-atnrw9ew	259	70	-	-	HYPH
cord-323756-atnrw9ew	259	71	stranded	strand	VBN
cord-323756-atnrw9ew	259	72	RNA	RNA	NNP
cord-323756-atnrw9ew	259	73	replicative	replicative	JJ
cord-323756-atnrw9ew	259	74	form	form	NN
cord-323756-atnrw9ew	259	75	in	in	IN
cord-323756-atnrw9ew	259	76	picornavirus	picornavirus	NN
cord-323756-atnrw9ew	259	77	-	-	HYPH
cord-323756-atnrw9ew	259	78	infected	infect	VBN
cord-323756-atnrw9ew	259	79	cells	cell	NNS
cord-323756-atnrw9ew	260	1	Innate	innate	JJ
cord-323756-atnrw9ew	260	2	immune	immune	JJ
cord-323756-atnrw9ew	260	3	response	response	NN
cord-323756-atnrw9ew	260	4	after	after	IN
cord-323756-atnrw9ew	260	5	adenoviral	adenoviral	NNP
cord-323756-atnrw9ew	260	6	gene	gene	NN
cord-323756-atnrw9ew	260	7	delivery	delivery	NN
cord-323756-atnrw9ew	260	8	into	into	IN
cord-323756-atnrw9ew	260	9	skin	skin	NN
cord-323756-atnrw9ew	260	10	is	be	VBZ
cord-323756-atnrw9ew	260	11	mediated	mediate	VBN
cord-323756-atnrw9ew	260	12	by	by	IN
cord-323756-atnrw9ew	260	13	AIM2	AIM2	NNP
cord-323756-atnrw9ew	260	14	,	,	,
cord-323756-atnrw9ew	260	15	NALP3	nalp3	XX
cord-323756-atnrw9ew	260	16	,	,	,
cord-323756-atnrw9ew	260	17	DAI	DAI	NNP
cord-323756-atnrw9ew	260	18	and	and	CC
cord-323756-atnrw9ew	260	19	mda5	mda5	NNS
cord-323756-atnrw9ew	260	20	Visualisation	Visualisation	NNP
cord-323756-atnrw9ew	260	21	of	of	IN
cord-323756-atnrw9ew	260	22	direct	direct	JJ
cord-323756-atnrw9ew	260	23	interaction	interaction	NN
cord-323756-atnrw9ew	260	24	of	of	IN
cord-323756-atnrw9ew	260	25	MDA5	MDA5	NNP
cord-323756-atnrw9ew	260	26	and	and	CC
cord-323756-atnrw9ew	260	27	the	the	DT
cord-323756-atnrw9ew	260	28	dsRNA	dsrna	NN
cord-323756-atnrw9ew	260	29	replicative	replicative	JJ
cord-323756-atnrw9ew	260	30	intermediate	intermediate	JJ
cord-323756-atnrw9ew	260	31	form	form	NN
cord-323756-atnrw9ew	260	32	of	of	IN
cord-323756-atnrw9ew	260	33	positive	positive	JJ
cord-323756-atnrw9ew	260	34	strand	strand	NN
cord-323756-atnrw9ew	260	35	RNA	RNA	NNP
cord-323756-atnrw9ew	260	36	viruses	virus	NNS
cord-323756-atnrw9ew	260	37	Activation	Activation	NNP
cord-323756-atnrw9ew	260	38	of	of	IN
cord-323756-atnrw9ew	260	39	IFN-&#946	ifn-&#946	CD
cord-323756-atnrw9ew	260	40	;	;	:
cord-323756-atnrw9ew	260	41	expression	expression	NN
cord-323756-atnrw9ew	260	42	by	by	IN
cord-323756-atnrw9ew	260	43	a	a	DT
cord-323756-atnrw9ew	260	44	viral	viral	JJ
cord-323756-atnrw9ew	260	45	mRNA	mrna	NN
cord-323756-atnrw9ew	260	46	through	through	IN
cord-323756-atnrw9ew	260	47	RNase	RNase	NNP
cord-323756-atnrw9ew	260	48	L	L	NNP
cord-323756-atnrw9ew	260	49	and	and	CC
cord-323756-atnrw9ew	260	50	MDA5	MDA5	NNP
cord-323756-atnrw9ew	260	51	New	New	NNP
cord-323756-atnrw9ew	260	52	insights	insight	NNS
cord-323756-atnrw9ew	260	53	into	into	IN
cord-323756-atnrw9ew	260	54	the	the	DT
cord-323756-atnrw9ew	260	55	role	role	NN
cord-323756-atnrw9ew	260	56	of	of	IN
cord-323756-atnrw9ew	260	57	RNase	RNase	NNP
cord-323756-atnrw9ew	260	58	L	L	NNP
cord-323756-atnrw9ew	260	59	in	in	IN
cord-323756-atnrw9ew	260	60	innate	innate	JJ
cord-323756-atnrw9ew	260	61	immunity	immunity	NN
cord-323756-atnrw9ew	260	62	Ribose	Ribose	NNP
cord-323756-atnrw9ew	260	63	2'-O	2'-o	CD
cord-323756-atnrw9ew	260	64	-	-	HYPH
cord-323756-atnrw9ew	260	65	methylation	methylation	NN
cord-323756-atnrw9ew	260	66	provides	provide	VBZ
cord-323756-atnrw9ew	260	67	a	a	DT
cord-323756-atnrw9ew	260	68	molecular	molecular	JJ
cord-323756-atnrw9ew	260	69	signature	signature	NN
cord-323756-atnrw9ew	260	70	for	for	IN
cord-323756-atnrw9ew	260	71	the	the	DT
cord-323756-atnrw9ew	260	72	distinction	distinction	NN
cord-323756-atnrw9ew	260	73	of	of	IN
cord-323756-atnrw9ew	260	74	self	self	NN
cord-323756-atnrw9ew	260	75	and	and	CC
cord-323756-atnrw9ew	260	76	non	non	JJ
cord-323756-atnrw9ew	260	77	-	-	JJ
cord-323756-atnrw9ew	260	78	self	self	JJ
cord-323756-atnrw9ew	260	79	mRNA	mrna	NN
cord-323756-atnrw9ew	260	80	dependent	dependent	JJ
cord-323756-atnrw9ew	260	81	on	on	IN
cord-323756-atnrw9ew	260	82	the	the	DT
cord-323756-atnrw9ew	260	83	RNA	RNA	NNP
cord-323756-atnrw9ew	260	84	sensor	sensor	NN
cord-323756-atnrw9ew	261	1	Mda5	Mda5	NNS
cord-323756-atnrw9ew	261	2	MAVS	MAVS	NNP
cord-323756-atnrw9ew	261	3	forms	form	VBZ
cord-323756-atnrw9ew	261	4	functional	functional	JJ
cord-323756-atnrw9ew	261	5	prion	prion	NN
cord-323756-atnrw9ew	261	6	-	-	HYPH
cord-323756-atnrw9ew	261	7	like	like	JJ
cord-323756-atnrw9ew	261	8	aggregates	aggregate	NNS
cord-323756-atnrw9ew	261	9	to	to	TO
cord-323756-atnrw9ew	261	10	activate	activate	VB
cord-323756-atnrw9ew	261	11	and	and	CC
cord-323756-atnrw9ew	261	12	propagate	propagate	VB
cord-323756-atnrw9ew	261	13	antiviral	antiviral	JJ
cord-323756-atnrw9ew	261	14	innate	innate	JJ
cord-323756-atnrw9ew	261	15	immune	immune	JJ
cord-323756-atnrw9ew	261	16	response	response	NN
cord-323756-atnrw9ew	262	1	Intracellular	Intracellular	NNP
cord-323756-atnrw9ew	262	2	pathogen	pathogen	NN
cord-323756-atnrw9ew	262	3	detection	detection	NN
cord-323756-atnrw9ew	262	4	by	by	IN
cord-323756-atnrw9ew	262	5	RIG	rig	NN
cord-323756-atnrw9ew	262	6	-	-	HYPH
cord-323756-atnrw9ew	262	7	I	i	NN
cord-323756-atnrw9ew	262	8	-	-	HYPH
cord-323756-atnrw9ew	262	9	like	like	JJ
cord-323756-atnrw9ew	262	10	receptors	receptor	NNS
cord-323756-atnrw9ew	263	1	The	the	DT
cord-323756-atnrw9ew	263	2	adaptor	adaptor	NN
cord-323756-atnrw9ew	263	3	MAVS	MAVS	NNPS
cord-323756-atnrw9ew	263	4	promotes	promote	VBZ
cord-323756-atnrw9ew	263	5	NLRP3	nlrp3	NN
cord-323756-atnrw9ew	263	6	mitochondrial	mitochondrial	JJ
cord-323756-atnrw9ew	263	7	localization	localization	NN
cord-323756-atnrw9ew	263	8	and	and	CC
cord-323756-atnrw9ew	263	9	inflammasome	inflammasome	NN
cord-323756-atnrw9ew	263	10	activation	activation	NN
cord-323756-atnrw9ew	263	11	Recognition	Recognition	NNP
cord-323756-atnrw9ew	263	12	of	of	IN
cord-323756-atnrw9ew	263	13	RNA	RNA	NNP
cord-323756-atnrw9ew	263	14	virus	virus	NN
cord-323756-atnrw9ew	263	15	by	by	IN
cord-323756-atnrw9ew	263	16	RIG	rig	NN
cord-323756-atnrw9ew	264	1	-I	-i	WDT
cord-323756-atnrw9ew	264	2	results	result	NNS
cord-323756-atnrw9ew	264	3	in	in	IN
cord-323756-atnrw9ew	264	4	activation	activation	NN
cord-323756-atnrw9ew	264	5	of	of	IN
cord-323756-atnrw9ew	264	6	CARD9	CARD9	NNP
cord-323756-atnrw9ew	264	7	and	and	CC
cord-323756-atnrw9ew	264	8	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	264	9	signaling	signal	VBG
cord-323756-atnrw9ew	264	10	for	for	IN
cord-323756-atnrw9ew	264	11	interleukin	interleukin	NN
cord-323756-atnrw9ew	264	12	1	1	CD
cord-323756-atnrw9ew	264	13	beta	beta	NN
cord-323756-atnrw9ew	264	14	production	production	NN
cord-323756-atnrw9ew	264	15	Type	type	NN
cord-323756-atnrw9ew	265	1	I	-PRON-	PRP
cord-323756-atnrw9ew	265	2	IFN	IFN	NNP
cord-323756-atnrw9ew	265	3	triggers	trigger	VBZ
cord-323756-atnrw9ew	265	4	RIG	rig	NN
cord-323756-atnrw9ew	266	1	-I	-I	NNP
cord-323756-atnrw9ew	266	2	/	/	SYM
cord-323756-atnrw9ew	266	3	TLR3	TLR3	NNP
cord-323756-atnrw9ew	266	4	/	/	SYM
cord-323756-atnrw9ew	266	5	NLRP3-dependent	NLRP3-dependent	NNP
cord-323756-atnrw9ew	266	6	inflammasome	inflammasome	NN
cord-323756-atnrw9ew	266	7	activation	activation	NN
cord-323756-atnrw9ew	266	8	in	in	IN
cord-323756-atnrw9ew	266	9	influenza	influenza	NN
cord-323756-atnrw9ew	266	10	A	a	DT
cord-323756-atnrw9ew	266	11	virus	virus	NN
cord-323756-atnrw9ew	266	12	infected	infect	VBN
cord-323756-atnrw9ew	266	13	cells	cell	NNS
cord-323756-atnrw9ew	267	1	The	the	DT
cord-323756-atnrw9ew	267	2	RIG	rig	NN
cord-323756-atnrw9ew	267	3	-	-	HYPH
cord-323756-atnrw9ew	267	4	I	i	NN
cord-323756-atnrw9ew	267	5	-	-	HYPH
cord-323756-atnrw9ew	267	6	like	like	JJ
cord-323756-atnrw9ew	267	7	receptor	receptor	NN
cord-323756-atnrw9ew	267	8	LGP2	LGP2	NNP
cord-323756-atnrw9ew	267	9	recognizes	recognize	VBZ
cord-323756-atnrw9ew	267	10	the	the	DT
cord-323756-atnrw9ew	267	11	termini	terminus	NNS
cord-323756-atnrw9ew	267	12	of	of	IN
cord-323756-atnrw9ew	267	13	double	double	RB
cord-323756-atnrw9ew	267	14	-	-	HYPH
cord-323756-atnrw9ew	267	15	stranded	strand	VBN
cord-323756-atnrw9ew	267	16	RNA	rna	NN
cord-323756-atnrw9ew	268	1	The	the	DT
cord-323756-atnrw9ew	268	2	regulatory	regulatory	JJ
cord-323756-atnrw9ew	268	3	domain	domain	NN
cord-323756-atnrw9ew	268	4	of	of	IN
cord-323756-atnrw9ew	268	5	the	the	DT
cord-323756-atnrw9ew	268	6	RIG	rig	NN
cord-323756-atnrw9ew	268	7	-	-	:
cord-323756-atnrw9ew	268	8	I	-PRON-	PRP
cord-323756-atnrw9ew	268	9	family	family	NN
cord-323756-atnrw9ew	268	10	ATPase	ATPase	NNP
cord-323756-atnrw9ew	268	11	LGP2	LGP2	NNP
cord-323756-atnrw9ew	268	12	senses	sense	VBZ
cord-323756-atnrw9ew	268	13	doublestranded	doublestrande	VBD
cord-323756-atnrw9ew	268	14	RNA	RNA	NNP
cord-323756-atnrw9ew	268	15	LGP2	LGP2	NNP
cord-323756-atnrw9ew	268	16	is	be	VBZ
cord-323756-atnrw9ew	268	17	a	a	DT
cord-323756-atnrw9ew	268	18	positive	positive	JJ
cord-323756-atnrw9ew	268	19	regulator	regulator	NN
cord-323756-atnrw9ew	268	20	of	of	IN
cord-323756-atnrw9ew	268	21	RIG	rig	NN
cord-323756-atnrw9ew	268	22	-	-	HYPH
cord-323756-atnrw9ew	268	23	I	I	NNP
cord-323756-atnrw9ew	268	24	-	-	HYPH
cord-323756-atnrw9ew	268	25	and	and	CC
cord-323756-atnrw9ew	268	26	MDA5-mediated	MDA5-mediated	NNP
cord-323756-atnrw9ew	268	27	antiviral	antiviral	JJ
cord-323756-atnrw9ew	268	28	responses	response	NNS
cord-323756-atnrw9ew	269	1	ATP	ATP	NNP
cord-323756-atnrw9ew	269	2	hydrolysis	hydrolysis	NN
cord-323756-atnrw9ew	269	3	enhances	enhance	VBZ
cord-323756-atnrw9ew	269	4	RNA	RNA	NNP
cord-323756-atnrw9ew	269	5	recognition	recognition	NN
cord-323756-atnrw9ew	269	6	and	and	CC
cord-323756-atnrw9ew	269	7	antiviral	antiviral	JJ
cord-323756-atnrw9ew	269	8	signal	signal	NN
cord-323756-atnrw9ew	269	9	transduction	transduction	NN
cord-323756-atnrw9ew	269	10	by	by	IN
cord-323756-atnrw9ew	269	11	the	the	DT
cord-323756-atnrw9ew	269	12	innate	innate	JJ
cord-323756-atnrw9ew	269	13	immune	immune	JJ
cord-323756-atnrw9ew	269	14	sensor	sensor	NN
cord-323756-atnrw9ew	269	15	,	,	,
cord-323756-atnrw9ew	269	16	laboratory	laboratory	NN
cord-323756-atnrw9ew	269	17	of	of	IN
cord-323756-atnrw9ew	269	18	genetics	genetic	NNS
cord-323756-atnrw9ew	269	19	and	and	CC
cord-323756-atnrw9ew	269	20	physiology	physiology	NN
cord-323756-atnrw9ew	269	21	2	2	CD
cord-323756-atnrw9ew	270	1	(	(	-LRB-
cord-323756-atnrw9ew	270	2	LGP2	LGP2	NNP
cord-323756-atnrw9ew	270	3	)	)	-RRB-
cord-323756-atnrw9ew	270	4	LGP2	LGP2	NNP
cord-323756-atnrw9ew	270	5	plays	play	VBZ
cord-323756-atnrw9ew	270	6	a	a	DT
cord-323756-atnrw9ew	270	7	critical	critical	JJ
cord-323756-atnrw9ew	270	8	role	role	NN
cord-323756-atnrw9ew	270	9	in	in	IN
cord-323756-atnrw9ew	270	10	sensitizing	sensitize	VBG
cord-323756-atnrw9ew	270	11	mda-5	mda-5	CD
cord-323756-atnrw9ew	270	12	to	to	TO
cord-323756-atnrw9ew	270	13	activation	activation	NN
cord-323756-atnrw9ew	270	14	by	by	IN
cord-323756-atnrw9ew	270	15	double	double	RB
cord-323756-atnrw9ew	270	16	-	-	HYPH
cord-323756-atnrw9ew	270	17	stranded	strand	VBN
cord-323756-atnrw9ew	270	18	RNA	RNA	NNP
cord-323756-atnrw9ew	270	19	From	from	IN
cord-323756-atnrw9ew	270	20	unwinding	unwind	VBG
cord-323756-atnrw9ew	270	21	to	to	IN
cord-323756-atnrw9ew	270	22	clamping	clamp	VBG
cord-323756-atnrw9ew	270	23	-the	-the	DT
cord-323756-atnrw9ew	270	24	DEAD	DEAD	NNP
cord-323756-atnrw9ew	270	25	box	box	NN
cord-323756-atnrw9ew	270	26	RNA	RNA	NNP
cord-323756-atnrw9ew	270	27	helicase	helicase	NN
cord-323756-atnrw9ew	270	28	family	family	NN
cord-323756-atnrw9ew	270	29	DExD	DExD	NNS
cord-323756-atnrw9ew	270	30	/	/	SYM
cord-323756-atnrw9ew	270	31	H	H	NNP
cord-323756-atnrw9ew	270	32	-	-	HYPH
cord-323756-atnrw9ew	270	33	box	box	NN
cord-323756-atnrw9ew	270	34	RNA	RNA	NNP
cord-323756-atnrw9ew	270	35	helicases	helicase	NNS
cord-323756-atnrw9ew	270	36	as	as	IN
cord-323756-atnrw9ew	270	37	mediators	mediator	NNS
cord-323756-atnrw9ew	270	38	of	of	IN
cord-323756-atnrw9ew	270	39	anti	anti	JJ
cord-323756-atnrw9ew	270	40	-	-	JJ
cord-323756-atnrw9ew	270	41	viral	viral	JJ
cord-323756-atnrw9ew	270	42	innate	innate	JJ
cord-323756-atnrw9ew	270	43	immunity	immunity	NN
cord-323756-atnrw9ew	270	44	and	and	CC
cord-323756-atnrw9ew	270	45	essential	essential	JJ
cord-323756-atnrw9ew	270	46	host	host	NN
cord-323756-atnrw9ew	270	47	factors	factor	NNS
cord-323756-atnrw9ew	270	48	for	for	IN
cord-323756-atnrw9ew	270	49	viral	viral	JJ
cord-323756-atnrw9ew	270	50	replication	replication	NN
cord-323756-atnrw9ew	271	1	DEAD	DEAD	NNP
cord-323756-atnrw9ew	271	2	/	/	SYM
cord-323756-atnrw9ew	271	3	H	h	NN
cord-323756-atnrw9ew	271	4	BOX	box	NN
cord-323756-atnrw9ew	271	5	3	3	CD
cord-323756-atnrw9ew	272	1	(	(	-LRB-
cord-323756-atnrw9ew	272	2	DDX3	DDX3	NNP
cord-323756-atnrw9ew	272	3	)	)	-RRB-
cord-323756-atnrw9ew	272	4	helicase	helicase	NNP
cord-323756-atnrw9ew	272	5	binds	bind	VBZ
cord-323756-atnrw9ew	272	6	the	the	DT
cord-323756-atnrw9ew	272	7	RIG	rig	NN
cord-323756-atnrw9ew	272	8	-	-	:
cord-323756-atnrw9ew	272	9	I	i	NN
cord-323756-atnrw9ew	272	10	adaptor	adaptor	NN
cord-323756-atnrw9ew	272	11	IPS-1	IPS-1	NNP
cord-323756-atnrw9ew	273	1	to	to	TO
cord-323756-atnrw9ew	273	2	up	up	RB
cord-323756-atnrw9ew	273	3	-	-	HYPH
cord-323756-atnrw9ew	273	4	regulate	regulate	VB
cord-323756-atnrw9ew	273	5	IFN	IFN	NNP
cord-323756-atnrw9ew	273	6	-	-	HYPH
cord-323756-atnrw9ew	273	7	beta	beta	NN
cord-323756-atnrw9ew	273	8	-	-	HYPH
cord-323756-atnrw9ew	273	9	inducing	induce	VBG
cord-323756-atnrw9ew	273	10	potential	potential	JJ
cord-323756-atnrw9ew	273	11	Viral	viral	JJ
cord-323756-atnrw9ew	273	12	targeting	targeting	NN
cord-323756-atnrw9ew	273	13	of	of	IN
cord-323756-atnrw9ew	273	14	DEAD	DEAD	NNP
cord-323756-atnrw9ew	273	15	box	box	NN
cord-323756-atnrw9ew	273	16	protein	protein	NN
cord-323756-atnrw9ew	273	17	3	3	CD
cord-323756-atnrw9ew	273	18	reveals	reveal	VBZ
cord-323756-atnrw9ew	273	19	its	-PRON-	PRP$
cord-323756-atnrw9ew	273	20	role	role	NN
cord-323756-atnrw9ew	273	21	in	in	IN
cord-323756-atnrw9ew	273	22	TBK1	TBK1	NNP
cord-323756-atnrw9ew	273	23	/	/	SYM
cord-323756-atnrw9ew	273	24	IKKepsilon	IKKepsilon	NNP
cord-323756-atnrw9ew	273	25	-	-	HYPH
cord-323756-atnrw9ew	273	26	mediated	mediate	VBN
cord-323756-atnrw9ew	273	27	IRF	IRF	NNP
cord-323756-atnrw9ew	273	28	activation	activation	NN
cord-323756-atnrw9ew	274	1	Hepatitis	Hepatitis	NNP
cord-323756-atnrw9ew	274	2	C	C	NNP
cord-323756-atnrw9ew	274	3	virus	virus	NN
cord-323756-atnrw9ew	274	4	core	core	NN
cord-323756-atnrw9ew	274	5	protein	protein	NN
cord-323756-atnrw9ew	274	6	abrogates	abrogate	VBZ
cord-323756-atnrw9ew	274	7	the	the	DT
cord-323756-atnrw9ew	274	8	DDX3	DDX3	NNP
cord-323756-atnrw9ew	274	9	function	function	NN
cord-323756-atnrw9ew	274	10	that	that	WDT
cord-323756-atnrw9ew	274	11	enhances	enhance	VBZ
cord-323756-atnrw9ew	274	12	IPS-1-mediated	ips-1-mediate	VBN
cord-323756-atnrw9ew	274	13	IFN	IFN	NNP
cord-323756-atnrw9ew	274	14	-	-	HYPH
cord-323756-atnrw9ew	274	15	beta	beta	NN
cord-323756-atnrw9ew	274	16	induction	induction	NN
cord-323756-atnrw9ew	274	17	DHX9	DHX9	NNP
cord-323756-atnrw9ew	274	18	pairs	pair	NNS
cord-323756-atnrw9ew	274	19	with	with	IN
cord-323756-atnrw9ew	274	20	IPS-1	IPS-1	NNP
cord-323756-atnrw9ew	274	21	to	to	TO
cord-323756-atnrw9ew	274	22	sense	sense	VB
cord-323756-atnrw9ew	274	23	double	double	RB
cord-323756-atnrw9ew	274	24	-	-	HYPH
cord-323756-atnrw9ew	274	25	stranded	strand	VBN
cord-323756-atnrw9ew	274	26	RNA	RNA	NNP
cord-323756-atnrw9ew	274	27	in	in	IN
cord-323756-atnrw9ew	274	28	myeloid	myeloid	JJ
cord-323756-atnrw9ew	274	29	dendritic	dendritic	JJ
cord-323756-atnrw9ew	274	30	cells	cell	NNS
cord-323756-atnrw9ew	274	31	DDX1	DDX1	NNP
cord-323756-atnrw9ew	274	32	,	,	,
cord-323756-atnrw9ew	274	33	DDX21	DDX21	NNP
cord-323756-atnrw9ew	274	34	,	,	,
cord-323756-atnrw9ew	274	35	and	and	CC
cord-323756-atnrw9ew	274	36	DHX36	DHX36	NNP
cord-323756-atnrw9ew	274	37	helicases	helicase	NNS
cord-323756-atnrw9ew	274	38	form	form	VB
cord-323756-atnrw9ew	274	39	a	a	DT
cord-323756-atnrw9ew	274	40	complex	complex	NN
cord-323756-atnrw9ew	274	41	with	with	IN
cord-323756-atnrw9ew	274	42	the	the	DT
cord-323756-atnrw9ew	274	43	adaptor	adaptor	NN
cord-323756-atnrw9ew	274	44	molecule	molecule	NN
cord-323756-atnrw9ew	274	45	TRIF	TRIF	NNP
cord-323756-atnrw9ew	274	46	to	to	TO
cord-323756-atnrw9ew	274	47	sense	sense	VB
cord-323756-atnrw9ew	274	48	dsRNA	dsrna	JJ
cord-323756-atnrw9ew	274	49	in	in	IN
cord-323756-atnrw9ew	274	50	dendritic	dendritic	JJ
cord-323756-atnrw9ew	274	51	cells	cell	NNS
cord-323756-atnrw9ew	274	52	Aspartateglutamate	Aspartateglutamate	NNP
cord-323756-atnrw9ew	274	53	-	-	HYPH
cord-323756-atnrw9ew	274	54	alanine	alanine	NN
cord-323756-atnrw9ew	274	55	-	-	HYPH
cord-323756-atnrw9ew	274	56	histidine	histidine	NN
cord-323756-atnrw9ew	274	57	box	box	NN
cord-323756-atnrw9ew	274	58	motif	motif	NN
cord-323756-atnrw9ew	275	1	(	(	-LRB-
cord-323756-atnrw9ew	275	2	DEAH)/RNA	DEAH)/RNA	NNP
cord-323756-atnrw9ew	275	3	helicase	helicase	NNP
cord-323756-atnrw9ew	276	1	A	a	DT
cord-323756-atnrw9ew	276	2	helicases	helicase	NNS
cord-323756-atnrw9ew	276	3	sense	sense	VBP
cord-323756-atnrw9ew	276	4	microbial	microbial	JJ
cord-323756-atnrw9ew	276	5	DNA	dna	NN
cord-323756-atnrw9ew	276	6	in	in	IN
cord-323756-atnrw9ew	276	7	human	human	JJ
cord-323756-atnrw9ew	276	8	plasmacytoid	plasmacytoid	NN
cord-323756-atnrw9ew	276	9	dendritic	dendritic	JJ
cord-323756-atnrw9ew	276	10	cells	cell	NNS
cord-323756-atnrw9ew	277	1	The	the	DT
cord-323756-atnrw9ew	277	2	DHX33	DHX33	NNP
cord-323756-atnrw9ew	277	3	RNA	RNA	NNP
cord-323756-atnrw9ew	277	4	helicase	helicase	NN
cord-323756-atnrw9ew	277	5	senses	sense	VBZ
cord-323756-atnrw9ew	277	6	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	277	7	RNA	RNA	NNP
cord-323756-atnrw9ew	277	8	and	and	CC
cord-323756-atnrw9ew	277	9	activates	activate	VBZ
cord-323756-atnrw9ew	277	10	the	the	DT
cord-323756-atnrw9ew	277	11	NLRP3	nlrp3	XX
cord-323756-atnrw9ew	277	12	inflammasome	inflammasome	NNP
cord-323756-atnrw9ew	278	1	The	the	DT
cord-323756-atnrw9ew	278	2	interaction	interaction	NN
cord-323756-atnrw9ew	278	3	between	between	IN
cord-323756-atnrw9ew	278	4	the	the	DT
cord-323756-atnrw9ew	278	5	helicase	helicase	NN
cord-323756-atnrw9ew	278	6	DHX33	DHX33	NNP
cord-323756-atnrw9ew	278	7	and	and	CC
cord-323756-atnrw9ew	278	8	IPS-1	IPS-1	NNP
cord-323756-atnrw9ew	278	9	as	as	IN
cord-323756-atnrw9ew	278	10	a	a	DT
cord-323756-atnrw9ew	278	11	novel	novel	JJ
cord-323756-atnrw9ew	278	12	pathway	pathway	NN
cord-323756-atnrw9ew	278	13	to	to	TO
cord-323756-atnrw9ew	278	14	sense	sense	VB
cord-323756-atnrw9ew	278	15	double	double	RB
cord-323756-atnrw9ew	278	16	-	-	HYPH
cord-323756-atnrw9ew	278	17	stranded	strand	VBN
cord-323756-atnrw9ew	278	18	RNA	RNA	NNP
cord-323756-atnrw9ew	278	19	and	and	CC
cord-323756-atnrw9ew	278	20	RNA	RNA	NNP
cord-323756-atnrw9ew	278	21	viruses	virus	NNS
cord-323756-atnrw9ew	278	22	in	in	IN
cord-323756-atnrw9ew	278	23	myeloid	myeloid	JJ
cord-323756-atnrw9ew	278	24	dendritic	dendritic	JJ
cord-323756-atnrw9ew	278	25	cells	cell	NNS
cord-323756-atnrw9ew	278	26	DDX60	DDX60	NNP
cord-323756-atnrw9ew	278	27	,	,	,
cord-323756-atnrw9ew	278	28	a	a	DT
cord-323756-atnrw9ew	278	29	DEXD	DEXD	NNP
cord-323756-atnrw9ew	278	30	/	/	SYM
cord-323756-atnrw9ew	278	31	H	h	NN
cord-323756-atnrw9ew	278	32	box	box	NN
cord-323756-atnrw9ew	278	33	helicase	helicase	NN
cord-323756-atnrw9ew	278	34	,	,	,
cord-323756-atnrw9ew	278	35	is	be	VBZ
cord-323756-atnrw9ew	278	36	a	a	DT
cord-323756-atnrw9ew	278	37	novel	novel	JJ
cord-323756-atnrw9ew	278	38	antiviral	antiviral	JJ
cord-323756-atnrw9ew	278	39	factor	factor	NN
cord-323756-atnrw9ew	278	40	promoting	promote	VBG
cord-323756-atnrw9ew	278	41	RIG	rig	NN
cord-323756-atnrw9ew	278	42	-	-	HYPH
cord-323756-atnrw9ew	278	43	I	i	NN
cord-323756-atnrw9ew	278	44	-	-	HYPH
cord-323756-atnrw9ew	278	45	like	like	JJ
cord-323756-atnrw9ew	278	46	receptor	receptor	NN
cord-323756-atnrw9ew	278	47	-	-	HYPH
cord-323756-atnrw9ew	278	48	mediated	mediate	VBN
cord-323756-atnrw9ew	278	49	signaling	signal	VBG
cord-323756-atnrw9ew	278	50	Cytosolic	Cytosolic	NNP
cord-323756-atnrw9ew	278	51	sensing	sensing	NN
cord-323756-atnrw9ew	278	52	of	of	IN
cord-323756-atnrw9ew	278	53	viruses	virus	NNS
cord-323756-atnrw9ew	279	1	Interferon	interferon	NN
cord-323756-atnrw9ew	279	2	-	-	HYPH
cord-323756-atnrw9ew	279	3	inducible	inducible	JJ
cord-323756-atnrw9ew	279	4	antiviral	antiviral	JJ
cord-323756-atnrw9ew	279	5	effectors	effector	NNS
cord-323756-atnrw9ew	280	1	5'-Triphosphate	5'-triphosphate	JJ
cord-323756-atnrw9ew	280	2	-	-	HYPH
cord-323756-atnrw9ew	280	3	dependent	dependent	JJ
cord-323756-atnrw9ew	280	4	activation	activation	NN
cord-323756-atnrw9ew	280	5	of	of	IN
cord-323756-atnrw9ew	280	6	PKR	PKR	NNP
cord-323756-atnrw9ew	280	7	by	by	IN
cord-323756-atnrw9ew	280	8	RNAs	rna	NNS
cord-323756-atnrw9ew	280	9	with	with	IN
cord-323756-atnrw9ew	280	10	short	short	JJ
cord-323756-atnrw9ew	280	11	stem	stem	NN
cord-323756-atnrw9ew	280	12	-	-	HYPH
cord-323756-atnrw9ew	280	13	loops	loop	NNS
cord-323756-atnrw9ew	280	14	IFIT1	ifit1	RB
cord-323756-atnrw9ew	280	15	is	be	VBZ
cord-323756-atnrw9ew	280	16	an	an	DT
cord-323756-atnrw9ew	280	17	antiviral	antiviral	JJ
cord-323756-atnrw9ew	280	18	protein	protein	NN
cord-323756-atnrw9ew	280	19	that	that	WDT
cord-323756-atnrw9ew	280	20	recognizes	recognize	VBZ
cord-323756-atnrw9ew	280	21	5'-triphosphate	5'-triphosphate	CD
cord-323756-atnrw9ew	280	22	RNA	RNA	NNP
cord-323756-atnrw9ew	280	23	Structural	structural	JJ
cord-323756-atnrw9ew	280	24	basis	basis	NN
cord-323756-atnrw9ew	280	25	for	for	IN
cord-323756-atnrw9ew	280	26	viral	viral	JJ
cord-323756-atnrw9ew	280	27	5'-PPP	5'-ppp	CD
cord-323756-atnrw9ew	280	28	-	-	HYPH
cord-323756-atnrw9ew	280	29	RNA	rna	NN
cord-323756-atnrw9ew	280	30	recognition	recognition	NN
cord-323756-atnrw9ew	280	31	by	by	IN
cord-323756-atnrw9ew	280	32	human	human	JJ
cord-323756-atnrw9ew	280	33	IFIT	ifit	NN
cord-323756-atnrw9ew	280	34	proteins	protein	NNS
cord-323756-atnrw9ew	281	1	Ifit1	Ifit1	NNP
cord-323756-atnrw9ew	281	2	inhibits	inhibit	VBZ
cord-323756-atnrw9ew	281	3	Japanese	japanese	JJ
cord-323756-atnrw9ew	281	4	encephalitis	encephalitis	RB
cord-323756-atnrw9ew	281	5	virus	virus	NN
cord-323756-atnrw9ew	281	6	replication	replication	NN
cord-323756-atnrw9ew	281	7	through	through	IN
cord-323756-atnrw9ew	281	8	binding	bind	VBG
cord-323756-atnrw9ew	281	9	to	to	IN
cord-323756-atnrw9ew	281	10	5	5	CD
cord-323756-atnrw9ew	281	11	'	'	''
cord-323756-atnrw9ew	281	12	capped	cap	VBN
cord-323756-atnrw9ew	281	13	2'-O	2'-o	CD
cord-323756-atnrw9ew	281	14	unmethylated	unmethylate	VBN
cord-323756-atnrw9ew	281	15	RNA	RNA	NNP
cord-323756-atnrw9ew	281	16	2'-O	2'-o	CD
cord-323756-atnrw9ew	281	17	methylation	methylation	NNS
cord-323756-atnrw9ew	281	18	of	of	IN
cord-323756-atnrw9ew	281	19	the	the	DT
cord-323756-atnrw9ew	281	20	viral	viral	JJ
cord-323756-atnrw9ew	281	21	mRNA	mRNA	NNP
cord-323756-atnrw9ew	281	22	cap	cap	NN
cord-323756-atnrw9ew	281	23	evades	evade	VBZ
cord-323756-atnrw9ew	281	24	host	host	NN
cord-323756-atnrw9ew	281	25	restriction	restriction	NN
cord-323756-atnrw9ew	281	26	by	by	IN
cord-323756-atnrw9ew	281	27	IFIT	IFIT	NNP
cord-323756-atnrw9ew	281	28	family	family	NN
cord-323756-atnrw9ew	281	29	members	member	NNS
cord-323756-atnrw9ew	281	30	2'-O	2'-o	CD
cord-323756-atnrw9ew	281	31	methylation	methylation	NNS
cord-323756-atnrw9ew	281	32	of	of	IN
cord-323756-atnrw9ew	281	33	the	the	DT
cord-323756-atnrw9ew	281	34	viral	viral	JJ
cord-323756-atnrw9ew	281	35	mRNA	mRNA	NNP
cord-323756-atnrw9ew	281	36	cap	cap	NN
cord-323756-atnrw9ew	281	37	by	by	IN
cord-323756-atnrw9ew	281	38	West	West	NNP
cord-323756-atnrw9ew	281	39	Nile	Nile	NNP
cord-323756-atnrw9ew	281	40	virus	virus	NN
cord-323756-atnrw9ew	281	41	evades	evade	VBZ
cord-323756-atnrw9ew	281	42	ifit1-dependent	ifit1-dependent	JJ
cord-323756-atnrw9ew	281	43	and	and	CC
cord-323756-atnrw9ew	281	44	-independent	-independent	JJ
cord-323756-atnrw9ew	281	45	mechanisms	mechanism	NNS
cord-323756-atnrw9ew	281	46	of	of	IN
cord-323756-atnrw9ew	281	47	host	host	NN
cord-323756-atnrw9ew	281	48	restriction	restriction	NN
cord-323756-atnrw9ew	281	49	in	in	IN
cord-323756-atnrw9ew	281	50	vivo	vivo	NNP
cord-323756-atnrw9ew	281	51	Crystal	Crystal	NNP
cord-323756-atnrw9ew	281	52	structure	structure	NN
cord-323756-atnrw9ew	281	53	of	of	IN
cord-323756-atnrw9ew	281	54	ISG54	ISG54	NNP
cord-323756-atnrw9ew	282	1	reveals	reveal	VBZ
cord-323756-atnrw9ew	282	2	a	a	DT
cord-323756-atnrw9ew	282	3	novel	novel	JJ
cord-323756-atnrw9ew	282	4	RNA	RNA	NNP
cord-323756-atnrw9ew	282	5	binding	binding	NN
cord-323756-atnrw9ew	282	6	structure	structure	NN
cord-323756-atnrw9ew	282	7	and	and	CC
cord-323756-atnrw9ew	282	8	potential	potential	JJ
cord-323756-atnrw9ew	282	9	functional	functional	JJ
cord-323756-atnrw9ew	282	10	mechanisms	mechanism	NNS
cord-323756-atnrw9ew	282	11	Activation	Activation	NNP
cord-323756-atnrw9ew	282	12	of	of	IN
cord-323756-atnrw9ew	282	13	innate	innate	JJ
cord-323756-atnrw9ew	282	14	immune	immune	JJ
cord-323756-atnrw9ew	282	15	antiviral	antiviral	JJ
cord-323756-atnrw9ew	282	16	responses	response	NNS
cord-323756-atnrw9ew	282	17	by	by	IN
cord-323756-atnrw9ew	282	18	Nod2	Nod2	NNP
cord-323756-atnrw9ew	282	19	Critical	Critical	NNP
cord-323756-atnrw9ew	282	20	role	role	NN
cord-323756-atnrw9ew	282	21	for	for	IN
cord-323756-atnrw9ew	282	22	cryopyrin	cryopyrin	NNP
cord-323756-atnrw9ew	282	23	/	/	SYM
cord-323756-atnrw9ew	282	24	Nalp3	nalp3	XX
cord-323756-atnrw9ew	282	25	in	in	IN
cord-323756-atnrw9ew	282	26	activation	activation	NN
cord-323756-atnrw9ew	282	27	of	of	IN
cord-323756-atnrw9ew	282	28	caspase-1	caspase-1	NNP
cord-323756-atnrw9ew	282	29	in	in	IN
cord-323756-atnrw9ew	282	30	response	response	NN
cord-323756-atnrw9ew	282	31	to	to	IN
cord-323756-atnrw9ew	282	32	viral	viral	JJ
cord-323756-atnrw9ew	282	33	infection	infection	NN
cord-323756-atnrw9ew	282	34	and	and	CC
cord-323756-atnrw9ew	282	35	double	double	RB
cord-323756-atnrw9ew	282	36	-	-	HYPH
cord-323756-atnrw9ew	282	37	stranded	strand	VBN
cord-323756-atnrw9ew	282	38	RNA	rna	NN
cord-323756-atnrw9ew	283	1	The	the	DT
cord-323756-atnrw9ew	283	2	NLRP3	nlrp3	NN
cord-323756-atnrw9ew	283	3	inflammasome	inflammasome	NN
cord-323756-atnrw9ew	283	4	mediates	mediate	VBZ
cord-323756-atnrw9ew	283	5	in	in	IN
cord-323756-atnrw9ew	283	6	vivo	vivo	FW
cord-323756-atnrw9ew	283	7	innate	innate	JJ
cord-323756-atnrw9ew	283	8	immunity	immunity	NN
cord-323756-atnrw9ew	283	9	to	to	TO
cord-323756-atnrw9ew	283	10	influenza	influenza	NN
cord-323756-atnrw9ew	283	11	A	a	DT
cord-323756-atnrw9ew	283	12	virus	virus	NN
cord-323756-atnrw9ew	283	13	through	through	IN
cord-323756-atnrw9ew	283	14	recognition	recognition	NN
cord-323756-atnrw9ew	283	15	of	of	IN
cord-323756-atnrw9ew	283	16	viral	viral	JJ
cord-323756-atnrw9ew	283	17	RNA	RNA	NNP
cord-323756-atnrw9ew	284	1	The	the	DT
cord-323756-atnrw9ew	284	2	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	284	3	nucleic	nucleic	JJ
cord-323756-atnrw9ew	284	4	acid	acid	NN
cord-323756-atnrw9ew	284	5	sensor	sensor	NN
cord-323756-atnrw9ew	284	6	LRRFIP1	LRRFIP1	NNP
cord-323756-atnrw9ew	284	7	mediates	mediate	VBZ
cord-323756-atnrw9ew	284	8	the	the	DT
cord-323756-atnrw9ew	284	9	production	production	NN
cord-323756-atnrw9ew	284	10	of	of	IN
cord-323756-atnrw9ew	284	11	type	type	NN
cord-323756-atnrw9ew	285	1	I	-PRON-	PRP
cord-323756-atnrw9ew	285	2	interferon	interferon	RB
cord-323756-atnrw9ew	286	1	via	via	IN
cord-323756-atnrw9ew	286	2	a	a	DT
cord-323756-atnrw9ew	286	3	betacatenin	betacatenin	NN
cord-323756-atnrw9ew	286	4	-	-	HYPH
cord-323756-atnrw9ew	286	5	dependent	dependent	JJ
cord-323756-atnrw9ew	286	6	pathway	pathway	NN
cord-323756-atnrw9ew	286	7	Characterization	characterization	NN
cord-323756-atnrw9ew	286	8	of	of	IN
cord-323756-atnrw9ew	286	9	LRRFIP1	lrrfip1	DT
cord-323756-atnrw9ew	286	10	Patterns	pattern	NNS
cord-323756-atnrw9ew	286	11	of	of	IN
cord-323756-atnrw9ew	286	12	oligonucleotide	oligonucleotide	JJ
cord-323756-atnrw9ew	286	13	sequences	sequence	NNS
cord-323756-atnrw9ew	286	14	in	in	IN
cord-323756-atnrw9ew	286	15	viral	viral	JJ
cord-323756-atnrw9ew	286	16	and	and	CC
cord-323756-atnrw9ew	286	17	host	host	NN
cord-323756-atnrw9ew	286	18	cell	cell	NN
cord-323756-atnrw9ew	286	19	RNA	RNA	NNP
cord-323756-atnrw9ew	286	20	identify	identify	VBP
cord-323756-atnrw9ew	286	21	mediators	mediator	NNS
cord-323756-atnrw9ew	286	22	of	of	IN
cord-323756-atnrw9ew	286	23	the	the	DT
cord-323756-atnrw9ew	286	24	host	host	NN
cord-323756-atnrw9ew	286	25	innate	innate	JJ
cord-323756-atnrw9ew	286	26	immune	immune	JJ
cord-323756-atnrw9ew	286	27	system	system	NN
cord-323756-atnrw9ew	286	28	Oligonucleotide	Oligonucleotide	NNP
cord-323756-atnrw9ew	286	29	motifs	motif	NNS
cord-323756-atnrw9ew	286	30	that	that	WDT
cord-323756-atnrw9ew	286	31	disappear	disappear	VBP
cord-323756-atnrw9ew	286	32	during	during	IN
cord-323756-atnrw9ew	286	33	the	the	DT
cord-323756-atnrw9ew	286	34	evolution	evolution	NN
cord-323756-atnrw9ew	286	35	of	of	IN
cord-323756-atnrw9ew	286	36	influenza	influenza	NN
cord-323756-atnrw9ew	286	37	virus	virus	NN
cord-323756-atnrw9ew	286	38	in	in	IN
cord-323756-atnrw9ew	286	39	humans	human	NNS
cord-323756-atnrw9ew	286	40	increase	increase	VBP
cord-323756-atnrw9ew	286	41	alpha	alpha	NN
cord-323756-atnrw9ew	286	42	interferon	interferon	NN
cord-323756-atnrw9ew	286	43	secretion	secretion	NN
cord-323756-atnrw9ew	286	44	by	by	IN
cord-323756-atnrw9ew	286	45	plasmacytoid	plasmacytoid	NNP
cord-323756-atnrw9ew	286	46	dendritic	dendritic	JJ
cord-323756-atnrw9ew	286	47	cells	cell	NNS
cord-323756-atnrw9ew	287	1	The	the	DT
cord-323756-atnrw9ew	287	2	biased	biased	JJ
cord-323756-atnrw9ew	287	3	nucleotide	nucleotide	JJ
cord-323756-atnrw9ew	287	4	composition	composition	NN
cord-323756-atnrw9ew	287	5	of	of	IN
cord-323756-atnrw9ew	287	6	HIV-1	HIV-1	NNP
cord-323756-atnrw9ew	287	7	triggers	trigger	VBZ
cord-323756-atnrw9ew	287	8	type	type	NN
cord-323756-atnrw9ew	288	1	I	-PRON-	PRP
cord-323756-atnrw9ew	289	1	interferon	interferon	NNP
cord-323756-atnrw9ew	289	2	response	response	NN
cord-323756-atnrw9ew	289	3	and	and	CC
cord-323756-atnrw9ew	289	4	correlates	correlate	VBZ
cord-323756-atnrw9ew	289	5	with	with	IN
cord-323756-atnrw9ew	290	1	subtype	subtype	NN
cord-323756-atnrw9ew	290	2	D	D	NNP
cord-323756-atnrw9ew	290	3	increased	increase	VBD
cord-323756-atnrw9ew	290	4	pathogenicity	pathogenicity	NN
cord-323756-atnrw9ew	290	5	Nucleoside	nucleoside	NN
cord-323756-atnrw9ew	290	6	modifications	modification	NNS
cord-323756-atnrw9ew	290	7	modulate	modulate	VBP
cord-323756-atnrw9ew	290	8	activation	activation	NN
cord-323756-atnrw9ew	290	9	of	of	IN
cord-323756-atnrw9ew	290	10	the	the	DT
cord-323756-atnrw9ew	290	11	protein	protein	NN
cord-323756-atnrw9ew	290	12	kinase	kinase	VBZ
cord-323756-atnrw9ew	290	13	PKR	PKR	NNP
cord-323756-atnrw9ew	290	14	in	in	IN
cord-323756-atnrw9ew	290	15	an	an	DT
cord-323756-atnrw9ew	290	16	RNA	RNA	NNP
cord-323756-atnrw9ew	290	17	structure	structure	NN
cord-323756-atnrw9ew	290	18	-	-	HYPH
cord-323756-atnrw9ew	290	19	specific	specific	JJ
cord-323756-atnrw9ew	290	20	manner	manner	JJ
cord-323756-atnrw9ew	290	21	Native	native	JJ
cord-323756-atnrw9ew	290	22	tertiary	tertiary	JJ
cord-323756-atnrw9ew	290	23	structure	structure	NN
cord-323756-atnrw9ew	290	24	and	and	CC
cord-323756-atnrw9ew	290	25	nucleoside	nucleoside	NN
cord-323756-atnrw9ew	290	26	modifications	modification	NNS
cord-323756-atnrw9ew	291	1	suppress	suppress	VB
cord-323756-atnrw9ew	291	2	tRNA	tRNA	NNP
cord-323756-atnrw9ew	291	3	's	's	POS
cord-323756-atnrw9ew	291	4	intrinsic	intrinsic	JJ
cord-323756-atnrw9ew	291	5	ability	ability	NN
cord-323756-atnrw9ew	291	6	to	to	TO
cord-323756-atnrw9ew	291	7	activate	activate	VB
cord-323756-atnrw9ew	291	8	the	the	DT
cord-323756-atnrw9ew	291	9	innate	innate	JJ
cord-323756-atnrw9ew	291	10	immune	immune	JJ
cord-323756-atnrw9ew	291	11	sensor	sensor	NN
cord-323756-atnrw9ew	291	12	PKR	PKR	NNP
cord-323756-atnrw9ew	291	13	Inosine	Inosine	NNP
cord-323756-atnrw9ew	291	14	-	-	HYPH
cord-323756-atnrw9ew	291	15	containing	contain	VBG
cord-323756-atnrw9ew	291	16	RNA	RNA	NNP
cord-323756-atnrw9ew	291	17	is	be	VBZ
cord-323756-atnrw9ew	291	18	a	a	DT
cord-323756-atnrw9ew	291	19	novel	novel	JJ
cord-323756-atnrw9ew	291	20	innate	innate	JJ
cord-323756-atnrw9ew	291	21	immune	immune	JJ
cord-323756-atnrw9ew	291	22	recognition	recognition	NN
cord-323756-atnrw9ew	291	23	element	element	NN
cord-323756-atnrw9ew	291	24	and	and	CC
cord-323756-atnrw9ew	291	25	reduces	reduce	VBZ
cord-323756-atnrw9ew	291	26	RSV	RSV	NNP
cord-323756-atnrw9ew	291	27	infection	infection	NN
cord-323756-atnrw9ew	292	1	The	the	DT
cord-323756-atnrw9ew	292	2	mechanism	mechanism	NN
cord-323756-atnrw9ew	292	3	of	of	IN
cord-323756-atnrw9ew	292	4	eukaryotic	eukaryotic	JJ
cord-323756-atnrw9ew	292	5	translation	translation	NN
cord-323756-atnrw9ew	292	6	initiation	initiation	NN
cord-323756-atnrw9ew	292	7	and	and	CC
cord-323756-atnrw9ew	292	8	principles	principle	NNS
cord-323756-atnrw9ew	292	9	of	of	IN
cord-323756-atnrw9ew	292	10	its	-PRON-	PRP$
cord-323756-atnrw9ew	292	11	regulation	regulation	NN
cord-323756-atnrw9ew	292	12	Targeting	targeting	NN
cord-323756-atnrw9ew	292	13	of	of	IN
cord-323756-atnrw9ew	292	14	immune	immune	JJ
cord-323756-atnrw9ew	292	15	signalling	signalling	NN
cord-323756-atnrw9ew	292	16	networks	network	NNS
cord-323756-atnrw9ew	292	17	by	by	IN
cord-323756-atnrw9ew	292	18	bacterial	bacterial	JJ
cord-323756-atnrw9ew	292	19	pathogens	pathogen	NNS
cord-323756-atnrw9ew	292	20	Processing	Processing	NNP
cord-323756-atnrw9ew	292	21	of	of	IN
cord-323756-atnrw9ew	292	22	genome	genome	NN
cord-323756-atnrw9ew	292	23	5	5	CD
cord-323756-atnrw9ew	292	24	'	'	NN
cord-323756-atnrw9ew	292	25	termini	termini	NNP
cord-323756-atnrw9ew	292	26	as	as	IN
cord-323756-atnrw9ew	292	27	a	a	DT
cord-323756-atnrw9ew	292	28	strategy	strategy	NN
cord-323756-atnrw9ew	292	29	of	of	IN
cord-323756-atnrw9ew	292	30	negative	negative	JJ
cord-323756-atnrw9ew	292	31	-	-	HYPH
cord-323756-atnrw9ew	292	32	strand	strand	NN
cord-323756-atnrw9ew	292	33	RNA	RNA	NNP
cord-323756-atnrw9ew	292	34	viruses	virus	NNS
cord-323756-atnrw9ew	292	35	to	to	TO
cord-323756-atnrw9ew	292	36	avoid	avoid	VB
cord-323756-atnrw9ew	292	37	RIG	rig	NN
cord-323756-atnrw9ew	292	38	-	-	HYPH
cord-323756-atnrw9ew	292	39	I	i	NN
cord-323756-atnrw9ew	292	40	-	-	HYPH
cord-323756-atnrw9ew	292	41	dependent	dependent	JJ
cord-323756-atnrw9ew	292	42	interferon	interferon	NN
cord-323756-atnrw9ew	292	43	induction	induction	NN
cord-323756-atnrw9ew	292	44	Short	Short	NNP
cord-323756-atnrw9ew	292	45	doublestranded	doublestrande	VBD
cord-323756-atnrw9ew	292	46	RNAs	rna	NNS
cord-323756-atnrw9ew	292	47	with	with	IN
cord-323756-atnrw9ew	292	48	an	an	DT
cord-323756-atnrw9ew	292	49	overhanging	overhanging	JJ
cord-323756-atnrw9ew	292	50	5	5	CD
cord-323756-atnrw9ew	292	51	'	'	``
cord-323756-atnrw9ew	292	52	ppp	ppp	NN
cord-323756-atnrw9ew	292	53	-	-	HYPH
cord-323756-atnrw9ew	292	54	nucleotide	nucleotide	JJ
cord-323756-atnrw9ew	292	55	,	,	,
cord-323756-atnrw9ew	292	56	as	as	IN
cord-323756-atnrw9ew	292	57	found	find	VBN
cord-323756-atnrw9ew	292	58	in	in	IN
cord-323756-atnrw9ew	292	59	arenavirus	arenavirus	NNP
cord-323756-atnrw9ew	292	60	genomes	genome	NNS
cord-323756-atnrw9ew	292	61	,	,	,
cord-323756-atnrw9ew	292	62	act	act	VB
cord-323756-atnrw9ew	292	63	as	as	IN
cord-323756-atnrw9ew	292	64	RIG-	RIG-	NNP
cord-323756-atnrw9ew	293	1	I	-PRON-	PRP
cord-323756-atnrw9ew	293	2	decoys	decoy	VBZ
cord-323756-atnrw9ew	293	3	A	a	DT
cord-323756-atnrw9ew	293	4	new	new	JJ
cord-323756-atnrw9ew	293	5	evolutionary	evolutionary	JJ
cord-323756-atnrw9ew	293	6	law	law	NN
cord-323756-atnrw9ew	293	7	Identification	identification	NN
cord-323756-atnrw9ew	293	8	of	of	IN
cord-323756-atnrw9ew	293	9	modifications	modification	NNS
cord-323756-atnrw9ew	293	10	in	in	IN
cord-323756-atnrw9ew	293	11	microbial	microbial	JJ
cord-323756-atnrw9ew	293	12	,	,	,
cord-323756-atnrw9ew	293	13	native	native	JJ
cord-323756-atnrw9ew	293	14	tRNA	tRNA	NNP
cord-323756-atnrw9ew	294	1	that	that	DT
cord-323756-atnrw9ew	294	2	suppress	suppress	VBP
cord-323756-atnrw9ew	294	3	immunostimulatory	immunostimulatory	JJ
cord-323756-atnrw9ew	294	4	activity	activity	NN
cord-323756-atnrw9ew	295	1	The	the	DT
cord-323756-atnrw9ew	295	2	2'-O	2'-o	CD
cord-323756-atnrw9ew	295	3	-	-	HYPH
cord-323756-atnrw9ew	295	4	methylation	methylation	NN
cord-323756-atnrw9ew	295	5	status	status	NN
cord-323756-atnrw9ew	295	6	of	of	IN
cord-323756-atnrw9ew	295	7	a	a	DT
cord-323756-atnrw9ew	295	8	single	single	JJ
cord-323756-atnrw9ew	295	9	guanosine	guanosine	NN
cord-323756-atnrw9ew	295	10	controls	control	NNS
cord-323756-atnrw9ew	295	11	transfer	transfer	NN
cord-323756-atnrw9ew	295	12	RNA	RNA	NNP
cord-323756-atnrw9ew	295	13	-	-	HYPH
cord-323756-atnrw9ew	295	14	mediated	mediate	VBN
cord-323756-atnrw9ew	295	15	toll	toll	NN
cord-323756-atnrw9ew	295	16	-	-	HYPH
cord-323756-atnrw9ew	295	17	like	like	JJ
cord-323756-atnrw9ew	295	18	receptor	receptor	NN
cord-323756-atnrw9ew	295	19	7	7	CD
cord-323756-atnrw9ew	295	20	activation	activation	NN
cord-323756-atnrw9ew	295	21	or	or	CC
cord-323756-atnrw9ew	295	22	inhibition	inhibition	NN
cord-323756-atnrw9ew	295	23	Viral	viral	JJ
cord-323756-atnrw9ew	295	24	reorganization	reorganization	NN
cord-323756-atnrw9ew	295	25	of	of	IN
cord-323756-atnrw9ew	295	26	the	the	DT
cord-323756-atnrw9ew	295	27	secretory	secretory	JJ
cord-323756-atnrw9ew	295	28	pathway	pathway	NN
cord-323756-atnrw9ew	295	29	generates	generate	VBZ
cord-323756-atnrw9ew	295	30	distinct	distinct	JJ
cord-323756-atnrw9ew	295	31	organelles	organelle	NNS
cord-323756-atnrw9ew	295	32	for	for	IN
cord-323756-atnrw9ew	295	33	RNA	RNA	NNP
cord-323756-atnrw9ew	295	34	replication	replication	NN
cord-323756-atnrw9ew	295	35	Tick	tick	NN
cord-323756-atnrw9ew	295	36	-	-	HYPH
cord-323756-atnrw9ew	295	37	borne	bear	VBN
cord-323756-atnrw9ew	295	38	encephalitis	encephalitis	JJ
cord-323756-atnrw9ew	295	39	virus	virus	NN
cord-323756-atnrw9ew	295	40	delays	delay	NNS
cord-323756-atnrw9ew	295	41	interferon	interferon	VBP
cord-323756-atnrw9ew	295	42	induction	induction	NN
cord-323756-atnrw9ew	295	43	and	and	CC
cord-323756-atnrw9ew	295	44	hides	hide	VBZ
cord-323756-atnrw9ew	295	45	its	-PRON-	PRP$
cord-323756-atnrw9ew	295	46	double	double	RB
cord-323756-atnrw9ew	295	47	-	-	HYPH
cord-323756-atnrw9ew	295	48	stranded	strand	VBN
cord-323756-atnrw9ew	295	49	RNA	RNA	NNP
cord-323756-atnrw9ew	295	50	in	in	IN
cord-323756-atnrw9ew	295	51	intracellular	intracellular	JJ
cord-323756-atnrw9ew	295	52	membrane	membrane	NN
cord-323756-atnrw9ew	295	53	vesicles	vesicle	NNS
cord-323756-atnrw9ew	296	1	Delayed	delay	VBN
cord-323756-atnrw9ew	296	2	cytosolic	cytosolic	JJ
cord-323756-atnrw9ew	296	3	exposure	exposure	NN
cord-323756-atnrw9ew	296	4	of	of	IN
cord-323756-atnrw9ew	296	5	Japanese	japanese	JJ
cord-323756-atnrw9ew	296	6	encephalitis	encephalitis	RB
cord-323756-atnrw9ew	296	7	virus	virus	NN
cord-323756-atnrw9ew	296	8	double	double	RB
cord-323756-atnrw9ew	296	9	-	-	HYPH
cord-323756-atnrw9ew	296	10	stranded	strand	VBN
cord-323756-atnrw9ew	296	11	RNA	RNA	NNP
cord-323756-atnrw9ew	296	12	impedes	impede	VBZ
cord-323756-atnrw9ew	296	13	interferon	interferon	NN
cord-323756-atnrw9ew	296	14	activation	activation	NN
cord-323756-atnrw9ew	296	15	and	and	CC
cord-323756-atnrw9ew	296	16	enhances	enhance	VBZ
cord-323756-atnrw9ew	296	17	viral	viral	JJ
cord-323756-atnrw9ew	296	18	dissemination	dissemination	NN
cord-323756-atnrw9ew	296	19	in	in	IN
cord-323756-atnrw9ew	296	20	porcine	porcine	JJ
cord-323756-atnrw9ew	296	21	cells	cell	NNS
cord-323756-atnrw9ew	296	22	Formation	formation	NN
cord-323756-atnrw9ew	296	23	of	of	IN
cord-323756-atnrw9ew	296	24	membrane	membrane	NN
cord-323756-atnrw9ew	296	25	-	-	HYPH
cord-323756-atnrw9ew	296	26	defined	define	VBN
cord-323756-atnrw9ew	296	27	compartments	compartment	NNS
cord-323756-atnrw9ew	296	28	by	by	IN
cord-323756-atnrw9ew	296	29	tick	tick	NN
cord-323756-atnrw9ew	296	30	-	-	HYPH
cord-323756-atnrw9ew	296	31	borne	bear	VBN
cord-323756-atnrw9ew	296	32	encephalitis	encephalitis	JJ
cord-323756-atnrw9ew	296	33	virus	virus	NN
cord-323756-atnrw9ew	296	34	contributes	contribute	VBZ
cord-323756-atnrw9ew	296	35	to	to	IN
cord-323756-atnrw9ew	296	36	the	the	DT
cord-323756-atnrw9ew	296	37	early	early	JJ
cord-323756-atnrw9ew	296	38	delay	delay	NN
cord-323756-atnrw9ew	296	39	in	in	IN
cord-323756-atnrw9ew	296	40	interferon	interferon	NN
cord-323756-atnrw9ew	296	41	signaling	signal	VBG
cord-323756-atnrw9ew	296	42	X	x	NN
cord-323756-atnrw9ew	296	43	-	-	NN
cord-323756-atnrw9ew	296	44	ray	ray	JJ
cord-323756-atnrw9ew	296	45	structure	structure	NN
cord-323756-atnrw9ew	296	46	of	of	IN
cord-323756-atnrw9ew	296	47	NS1	ns1	NN
cord-323756-atnrw9ew	296	48	from	from	IN
cord-323756-atnrw9ew	296	49	a	a	DT
cord-323756-atnrw9ew	296	50	highly	highly	RB
cord-323756-atnrw9ew	296	51	pathogenic	pathogenic	JJ
cord-323756-atnrw9ew	296	52	H5N1	H5N1	NNP
cord-323756-atnrw9ew	296	53	influenza	influenza	NN
cord-323756-atnrw9ew	296	54	virus	virus	NN
cord-323756-atnrw9ew	297	1	The	the	DT
cord-323756-atnrw9ew	297	2	genome	genome	NN
cord-323756-atnrw9ew	297	3	-	-	HYPH
cord-323756-atnrw9ew	297	4	linked	link	VBN
cord-323756-atnrw9ew	297	5	protein	protein	NN
cord-323756-atnrw9ew	297	6	VPg	VPg	NNS
cord-323756-atnrw9ew	297	7	of	of	IN
cord-323756-atnrw9ew	297	8	vertebrate	vertebrate	JJ
cord-323756-atnrw9ew	297	9	viruses	virus	NNS
cord-323756-atnrw9ew	298	1	-a	-a	:
cord-323756-atnrw9ew	298	2	multifaceted	multifaceted	JJ
cord-323756-atnrw9ew	298	3	protein	protein	NN
cord-323756-atnrw9ew	298	4	Ebolavirus	ebolavirus	NN
cord-323756-atnrw9ew	298	5	VP35	VP35	NNP
cord-323756-atnrw9ew	298	6	uses	use	VBZ
cord-323756-atnrw9ew	298	7	a	a	DT
cord-323756-atnrw9ew	298	8	bimodal	bimodal	JJ
cord-323756-atnrw9ew	298	9	strategy	strategy	NN
cord-323756-atnrw9ew	298	10	to	to	TO
cord-323756-atnrw9ew	298	11	bind	bind	VB
cord-323756-atnrw9ew	298	12	dsRNA	dsrna	JJ
cord-323756-atnrw9ew	298	13	for	for	IN
cord-323756-atnrw9ew	298	14	innate	innate	JJ
cord-323756-atnrw9ew	298	15	immune	immune	JJ
cord-323756-atnrw9ew	298	16	suppression	suppression	NN
cord-323756-atnrw9ew	298	17	Structure	Structure	NNP
cord-323756-atnrw9ew	298	18	of	of	IN
cord-323756-atnrw9ew	298	19	the	the	DT
cord-323756-atnrw9ew	298	20	Lassa	Lassa	NNP
cord-323756-atnrw9ew	298	21	virus	virus	NN
cord-323756-atnrw9ew	298	22	nucleoprotein	nucleoprotein	NNP
cord-323756-atnrw9ew	299	1	reveals	reveal	VBZ
cord-323756-atnrw9ew	299	2	a	a	DT
cord-323756-atnrw9ew	299	3	dsRNA	dsrna	JJ
cord-323756-atnrw9ew	299	4	-	-	HYPH
cord-323756-atnrw9ew	299	5	specific	specific	JJ
cord-323756-atnrw9ew	299	6	3	3	CD
cord-323756-atnrw9ew	299	7	'	'	''
cord-323756-atnrw9ew	299	8	to	to	IN
cord-323756-atnrw9ew	299	9	5	5	CD
cord-323756-atnrw9ew	299	10	'	'	''
cord-323756-atnrw9ew	299	11	exonuclease	exonuclease	NN
cord-323756-atnrw9ew	299	12	activity	activity	NN
cord-323756-atnrw9ew	299	13	essential	essential	JJ
cord-323756-atnrw9ew	299	14	for	for	IN
cord-323756-atnrw9ew	299	15	immune	immune	JJ
cord-323756-atnrw9ew	299	16	suppression	suppression	NN
cord-323756-atnrw9ew	299	17	Structures	structure	NNS
cord-323756-atnrw9ew	299	18	of	of	IN
cord-323756-atnrw9ew	299	19	arenaviral	arenaviral	JJ
cord-323756-atnrw9ew	299	20	nucleoproteins	nucleoprotein	NNS
cord-323756-atnrw9ew	299	21	with	with	IN
cord-323756-atnrw9ew	299	22	triphosphate	triphosphate	NNP
cord-323756-atnrw9ew	299	23	dsRNA	dsRNA	NNS
cord-323756-atnrw9ew	299	24	reveal	reveal	VBP
cord-323756-atnrw9ew	299	25	a	a	DT
cord-323756-atnrw9ew	299	26	unique	unique	JJ
cord-323756-atnrw9ew	299	27	mechanism	mechanism	NN
cord-323756-atnrw9ew	299	28	of	of	IN
cord-323756-atnrw9ew	299	29	immune	immune	JJ
cord-323756-atnrw9ew	299	30	suppression	suppression	NN
cord-323756-atnrw9ew	300	1	The	the	DT
cord-323756-atnrw9ew	300	2	C	C	NNP
cord-323756-atnrw9ew	300	3	proteins	protein	NNS
cord-323756-atnrw9ew	300	4	of	of	IN
cord-323756-atnrw9ew	300	5	human	human	JJ
cord-323756-atnrw9ew	300	6	parainfluenza	parainfluenza	NNP
cord-323756-atnrw9ew	300	7	virus	virus	NNP
cord-323756-atnrw9ew	300	8	type	type	NN
cord-323756-atnrw9ew	300	9	1	1	CD
cord-323756-atnrw9ew	300	10	limit	limit	VBP
cord-323756-atnrw9ew	300	11	double	double	RB
cord-323756-atnrw9ew	300	12	-	-	HYPH
cord-323756-atnrw9ew	300	13	stranded	strand	VBN
cord-323756-atnrw9ew	300	14	RNA	RNA	NNP
cord-323756-atnrw9ew	300	15	accumulation	accumulation	NN
cord-323756-atnrw9ew	300	16	that	that	WDT
cord-323756-atnrw9ew	300	17	would	would	MD
cord-323756-atnrw9ew	300	18	otherwise	otherwise	RB
cord-323756-atnrw9ew	300	19	trigger	trigger	VB
cord-323756-atnrw9ew	300	20	activation	activation	NN
cord-323756-atnrw9ew	300	21	of	of	IN
cord-323756-atnrw9ew	300	22	MDA5	MDA5	NNP
cord-323756-atnrw9ew	300	23	and	and	CC
cord-323756-atnrw9ew	300	24	protein	protein	NN
cord-323756-atnrw9ew	300	25	kinase	kinase	NN
cord-323756-atnrw9ew	300	26	R	r	NN
cord-323756-atnrw9ew	301	1	The	the	DT
cord-323756-atnrw9ew	301	2	authors	author	NNS
cord-323756-atnrw9ew	301	3	declare	declare	VBP
cord-323756-atnrw9ew	301	4	that	that	IN
cord-323756-atnrw9ew	301	5	the	the	DT
cord-323756-atnrw9ew	301	6	research	research	NN
cord-323756-atnrw9ew	301	7	was	be	VBD
cord-323756-atnrw9ew	301	8	conducted	conduct	VBN
cord-323756-atnrw9ew	301	9	in	in	IN
cord-323756-atnrw9ew	301	10	the	the	DT
cord-323756-atnrw9ew	301	11	absence	absence	NN
cord-323756-atnrw9ew	301	12	of	of	IN
cord-323756-atnrw9ew	301	13	any	any	DT
cord-323756-atnrw9ew	301	14	commercial	commercial	JJ
cord-323756-atnrw9ew	301	15	or	or	CC
cord-323756-atnrw9ew	301	16	financial	financial	JJ
cord-323756-atnrw9ew	301	17	relationships	relationship	NNS
cord-323756-atnrw9ew	301	18	that	that	WDT
cord-323756-atnrw9ew	301	19	could	could	MD
cord-323756-atnrw9ew	301	20	be	be	VB
cord-323756-atnrw9ew	301	21	construed	construe	VBN
cord-323756-atnrw9ew	301	22	as	as	IN
cord-323756-atnrw9ew	301	23	a	a	DT
cord-323756-atnrw9ew	301	24	potential	potential	JJ
cord-323756-atnrw9ew	301	25	conflict	conflict	NN
cord-323756-atnrw9ew	301	26	of	of	IN
cord-323756-atnrw9ew	301	27	interest	interest	NN
cord-323756-atnrw9ew	301	28	.	.	.