id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103784-f8ac21m2	Campbell, C.	Risk factors for the development of hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection: a systematic review and meta-analysis	2020-08-24		.txt	text/plain	5148	301	46	title: Risk factors for the development of hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection: a systematic review and meta-analysis Methods: MEDLINE, Embase and Web of Science databases were searched from 1st January 2000 to 24th June 2020 for English studies investigating associations of metabolic factors and comorbidities with HCC risk in individuals with chronic HBV infection. Conclusions: In adults with chronic HBV infection, diabetes mellitus is a significant risk factor for HCC, but further investigation of how antidiabetic drug use and glycaemic control influence this association is needed. Therefore, we undertook a systematic review, aiming to summarise and critically appraise studies investigating associations of relevant comorbidities and metabolic factors with risk of HCC in CHB-infected individuals. DM was associated with an increased risk of progression to HCC by meta-analysis restricted to HRs minimally adjusted for age and sex ( Figure 2 ). Effect estimates for case-control studies investigating the association of diabetes mellitus with hepatocellular carcinoma risk.	./cache/cord-103784-f8ac21m2.txt	./txt/cord-103784-f8ac21m2.txt