id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002238-fyztb8d9	Young, D. F.	Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family	2016-09-29		.txt	text/plain	7727	344	51	We have previously shown that IFIT1 is primarily responsible for the antiviral action of interferon (IFN) alpha/beta against parainfluenza virus type 5 (PIV5), selectively inhibiting the translation of PIV5 mRNAs. Here we report that while PIV2, PIV5, and mumps virus (MuV) are sensitive to IFIT1, nonrubulavirus members of the paramyxoviridae such as PIV3, Sendai virus (SeV), and canine distemper virus (CDV) are resistant. Despite their limited genetic information, the majority of paramyxoviruses encode small multifunctional accessory proteins that function to aid virus multiplication and block cellular antiviral defense mechanisms; typically, these proteins can block both the production of, and the signaling response to, interferons (IFNs) (for reviews, see references 3, 4, 5, 6, and 7). These results therefore show that MuV Enders is sensitive to IFIT1 but SeV and CDV are not, the weak inhibition of SeV and CDV protein synthesis observed in A549 and A549/shIFIT1 cells pretreated with IFN presumably being due to the action of other ISGs induced by IFN.	./cache/cord-002238-fyztb8d9.txt	./txt/cord-002238-fyztb8d9.txt