id author title date pages extension mime words sentences flesch summary cache txt cord-002687-ql6zo8ka Li, Dan A potent human neutralizing antibody Fc-dependently reduces established HBV infections 2017-09-26 .txt text/plain 14698 772 55 Neutralizing antibodies (nAbs), in addition to their capacity to specifically block viral entry via Fab (fragment of antigen binding) recognition of virus, have been found to exert a variety of immunological 'effector' functions, including clearance of circulatory viruses as well as by mediating cytotoxic killing or phagocytosis of infected cells (DiLillo et al., 2014; Corti et al., 2011; Bournazos et al., 2014; Bruel et al., 2016; Lu et al., 2016; Hessell et al., 2007) , or even possibly triggering sustained host immune responses in vivo Pelegrin et al., 2015) . In the present study, we took advantage of a large non-immune phage display human antibody library and our human NTCP-enabled HBV cell culture system (Yan et al., 2012; Sun et al., 2016) to identify a panel of nAbs that specifically target the preS1 domain. ./cache/cord-002687-ql6zo8ka.txt ./txt/cord-002687-ql6zo8ka.txt