id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003104-9cx1gdze	Fitzsimmons, William J.	A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus	2018-06-28		.txt	text/plain	8643	457	55	Here, we present data for an alternative model whereby RNA viruses evolve high mutation rates as a byproduct of selection for increased replicative speed. However, the observed attenuation of antimutator RNA viruses in vivo has led many to argue for the adaptive benefit of high mutation rates, as genetic diversity provides a rich substrate for a virus's evolution in the face of varying intrahost environments [7, 10, [34] [35] [36] [37] [38] . This is a moderate fitness defect, falling in the 64th percentile in a dataset of 8,970 fitness values obtained for point mutants of poliovirus under similar conditions [16] (e.g., human epithelial cells [HeLa] multiplicity of infection [MOI] 0.1, 8-hour infection cycle, and 6 passages; Fig 1B) . The adaptability of WT and high-fidelity viruses have generally been compared using assays that measure the acquisition of drug resistance, the reversion of an attenuating point mutation, or escape from microRNA in a limited number of replication cycles [5] [6] [7] 34, 36] .	./cache/cord-003104-9cx1gdze.txt	./txt/cord-003104-9cx1gdze.txt