id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004274-cot05vx7	Jackson, Nicholas A. C.	The promise of mRNA vaccines: a biotech and industrial perspective	2020-02-04		.txt	text/plain	4253	251	38	"STATE-OF-THE-ART" mRNA CONSTRUCTS AND DELIVERY TECHNOLOGIES The core principle behind mRNA as a technology for vaccination is to deliver the transcript of interest, encoding one or more immunogen(s), into the host cell cytoplasm where expression generates translated protein(s) to be within the membrane, secreted or intracellularly located. Perspective #2: Translational sciences will inform preclinical and clinical studies to promote rapid downselection of constructs and formulations A key aspect of vaccine development efforts is the goal of making early informed decisions, based on objective data that favor or disfavor a particular candidate. 64 The current focus from a clinical perspective is to optimize the benefit (immunogenicity and efficacy) while reducing the risk (safety) profile of a candidate mRNA vaccine by optimizing the quality attributes that dictate expression and/or augmenting delivery. Thus, early-phase clinical trials need to be designed in a way to appropriately capture the inflammatory component intrinsic to all mRNA vaccines, given that several intracellular innate immune response sensors are activated by RNA.	./cache/cord-004274-cot05vx7.txt	./txt/cord-004274-cot05vx7.txt