id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102934-7e2mqooe	Dogra, N.	exRNA Signatures in Extracellular Vesicles and their Tumor-Lineage from Prostate Cancer	2020-09-30		.txt	text/plain	5830	385	51	Here, we established 60 total small RNA-sequencing profiles from 17 aggressive prostate cancer (PCa) patients tumor and adjacent normal tissue, and EVs isolated from urine, serum, and cancer cell culture media. We interrogated the key satellite alteration in tumor-derived EVs and found that resection of tumor prostate tissue leads to differential expression of reactive oxygen species (ROS), P53 pathways, inflammatory/cytokines, oncogenes, and tumor suppressor genes in the EV nanosatellites. We have conducted the total small RNA sequencing (n = 60) of aggressive prostate cancer patients (n = 17) tumor and adjacent normal tissue and EVs from urine, serum, and 22RV1 PCa cell line. We interrogated the key satellite alteration in tumor-derived EVs and found that resection of tumor prostate cancer tissue leads to differential expression of novel RNA biomarkers, ROS, P53 pathways, inflammatory/cytokines, major oncogenes, and tumor suppressors in the EV nanosatellites.	./cache/cord-102934-7e2mqooe.txt	./txt/cord-102934-7e2mqooe.txt