id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-122092-gdyt02er	Fatehi, Farzad	Comparing antiviral strategies against COVID-19 via multi-scale within host modelling	2020-10-18		.txt	text/plain	10080	511	55	Comparison of different scenarios is based on tissue damage and viral load, highlighting the impact(s) of antibodies and adaptive cell-mediated immune response on infection dynamics. Surprisingly, our model also suggests that early treatment by either therapy alone can actually increase the duration of infection compared with a later therapy start, likely because suppressing virus production results in a reduced immune response. The model also includes non-structural proteins that are important for the viral life cycle, such as the replicase-transcriptase complex (RTC), and keeps track of the numbers of gRNAs (and subgenomic sgRNAs) at different stages of the replication process. We have included additional reactions into the model that describe remdesivir binding to the RTC complexes on the gRNAs and sgRNAs to capture this (see SI for details), and track the effect of a given, fixed number of remdesivir molecules per cell on the release of viral particles from an infected host cell.	./cache/cord-122092-gdyt02er.txt	./txt/cord-122092-gdyt02er.txt